LOCUS       DAEQCW010000001       103377 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.001, whole genome shotgun sequence.
ACCESSION   DAEQCW010000001 DAEQCW010000000
VERSION     DAEQCW010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 103377)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 103377)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..103377
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.001"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(176..589)
                     /locus_tag="KRO40_000001"
     CDS             complement(176..589)
                     /locus_tag="KRO40_000001"
                     /EC_number="4.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylglyoxal synthase"
                     /protein_id="HBH2090848.1"
                     /translation="MNIALVAHDQMKNTMVGFCIGYESILKKYGLYATGTTGKRIMDE
                     TELNINRLASGPLGGDQQIGSLIVTQEIDLVIFLRDPLTSQAHETDIQALIRLCDVYH
                     VPIATNLASAEIFIKALDRGELSWREVRKSKSQRI"
     gene            complement(630..1760)
                     /gene="rodA"
                     /locus_tag="KRO40_000002"
     CDS             complement(630..1760)
                     /gene="rodA"
                     /locus_tag="KRO40_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein RodA"
                     /protein_id="HBH2090849.1"
                     /translation="MKKININYKSTIKLIKQLDWKLIVTVLAIFIFGLVILSSATHAN
                     STGSYNQLIKQGLAFVLGIGMIIVILFFDYNLLGRYYKALYIISLILLAIVLLPGIGT
                     VKGGARSWINLGPLDLQTSEIVKLTFVLSYAKILESKKDKLNTLKEVMPVVVYSLPFI
                     GLLIAQPDLGTGIVFCCMIFAMLFTAGLSSKLIKRGIIILLVSMPLMYLMMADHQKVR
                     IEAFLNPEDVTLKGNYQVMQSLIAIGSGGVTGKGLYNGSQNQEDFLPVQDSDFIFAVV
                     GEELGVIGMAVLIILFMIFLLRLLAIARDAKDFYGTLIVVGVMGMFGYQIIQNIGMTV
                     ALIPVTGVTLPFVSYGGSSLLTSLANLGLVLNVCMRRKKINF"
     gene            complement(1845..2129)
                     /gene="minE"
                     /locus_tag="KRO40_000003"
     CDS             complement(1845..2129)
                     /gene="minE"
                     /locus_tag="KRO40_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division topological specificity factor
                     MinE"
                     /protein_id="HBH2090850.1"
                     /translation="MLDLFRVFSNEAKTSKSVAKERLKLVLVHDRVDCSPQLLEMIKT
                     DILKVIANYAEIEDDGLEIKMSKCRGEHDDKPVSALVANIPLKNIKDRCM"
     gene            complement(2147..2944)
                     /gene="minD"
                     /locus_tag="KRO40_000004"
     CDS             complement(2147..2944)
                     /gene="minD"
                     /locus_tag="KRO40_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinD"
                     /protein_id="HBH2090851.1"
                     /translation="MSEVIVITSGKGGVGKTTTAANLGTALSLENKKTVVVDADIGLR
                     NLDVVMGLENRIVYDIVDVVEGTCRLKQALIKDKRFDNLYLLPAAQTRDKNAVSVEQM
                     IDLCEKLKESFEYIIIDCPAGIEQGFKNAVAGADRAIVVTNPEISAVRDADRIIGLLE
                     ANEIKEIRLVINRIRNDMVKRGDMMDKQDIIEILAIDLLGLVPDDESIIISTNKGEPA
                     ILDSKSLAGQAYKNIAKRILNEEVPLLDLEVEDGFFGRLKKMFSMAK"
     gene            complement(2968..3651)
                     /locus_tag="KRO40_000005"
     CDS             complement(2968..3651)
                     /locus_tag="KRO40_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinC"
                     /protein_id="HBH2090852.1"
                     /translation="MSLREICSQELVEFKGNKRGIIVNIKREAPFEEIQEKIINKLEA
                     YVGFFNGAKISKINSDCLTDMEILELKEGITSRFDVEFVEDQKIEENSNFPTKYVNTL
                     RSGENIEFEGDVVILNDMKPGSKVLSKSNTVVMGDINAGAKVVAGGNVFVMGKIEGFV
                     HAGAEGNEFAYVVAGNLNPKILQIADNIAEAPDDEENYESESEISPEIAFVSNGRIVI
                     ESYLSKLDK"
     gene            complement(3749..6727)
                     /locus_tag="KRO40_000006"
     CDS             complement(3749..6727)
                     /locus_tag="KRO40_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HBH2090853.1"
                     /translation="MEENKQVDRLKIIKIVMGVIFLAILVKIIYMTTFKYEYYNELAE
                     NKTYKKLAIEAPRGEIKDRYGRLLAGNKNLFTVQVSGNDINKKDANKHSRANEISLKL
                     INLLERNGEEYVDEFPIYVENGKYYYTYDRDIREYKSENGIPNDYNAKESFYYLVDKL
                     ISAGILSQEDKRLDATRLQAKLNENGYYPPILVSKWMFTAERDKRDWLASYKIKETKL
                     SAKEAFEKVRNSDALEIDKSLSDEDARKIMVVRDLIKSKGYSQYNPVTIAKDVGETTI
                     AQIEESAMDLVGVSIAVEPVRYYPNGSLASHMLGYVGKMPSTQIESYLQKGYETGDMV
                     GLAGVEKSNESRLRGTDGYKMVKVDALGRISKEIESKKPKSGDTVYLTLDKDLQEVSD
                     NALKQIIEVASKGGTFKSKFGDKPISAYAGKAQSAALIAIDVKNGEVLASSSYPNYDP
                     NKFAKGISTEDYKALQPKNPNDLLAGSPLLNLVTQGEFQPGSSFKMVTSMAALENGLD
                     PNFTINDPGVIMLGKKSFGDYVWNHGRGNHGMTNLYKAIQESCNIYMATIGTGKTWPD
                     GKSIGIDMNANKILEYAKLFGLDQNTGLQDEVEERAGKVPSTEDKLKSTQALLKSNLE
                     REMANDFVDITREKNPKEYEKRINEIVSWAAEKKTPGRVETMNRLKKLDVKEDRIEEV
                     ADLAVFSYFNFAKWSTADTFNLAIGQGENAYTPAQISRYVAAIANGGNLVELSVVDRA
                     VSSDYSSVKINDQKKVEKIPFKNPDNLKELTKGMKLVARQGTAKSAFADFPIDVAAKT
                     GTAEKSGKIPTDNEYEYLKSHMSSYNVNLNDAIKLADKMKAEKEKELSLAKEKEIKKK
                     LENKDLKDEERKKLEEELEDGVKVRLEDTDKVNSSYLRKAIKELNPKITDDQIDRFKQ
                     DYGSFTWTVAFAPADDPEIAVVCVIPQGDSSVFSLLPTREVIGTYMGLEPTNSKNDNK
                     TNDVNNSSDENINFESQINR"
     gene            complement(6739..7227)
                     /gene="mreD"
                     /locus_tag="KRO40_000007"
     CDS             complement(6739..7227)
                     /gene="mreD"
                     /locus_tag="KRO40_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HBH2090854.1"
                     /translation="MKKVLLCLLGIVLMTIENSITNYIDIFGISFNLVLIYVTIISLY
                     LDELEGGIIAAIIGLIKDITVGGIFGVNALILFIIAYAIGYMRDQLYKGSYIITFVLI
                     FIGSLIDSIVNIGTSSIIYQSYNISTLFVKGLLVAPIVNSLIGLVIYRLSKRAVLKLK
                     ED"
     gene            complement(7242..8135)
                     /gene="mreC"
                     /locus_tag="KRO40_000008"
     CDS             complement(7242..8135)
                     /gene="mreC"
                     /locus_tag="KRO40_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HBH2090855.1"
                     /translation="MALRFDKNKNEKKRINVKVIATGVVAITLIGIVGISIGKFSSGS
                     PVNLGVASDAITSVGKGINDGFSFIKNGFKDVANFKDNSKKVKKLEEENEKLKKNMIA
                     LNAKLDKTESLEELKKTLNFVQEEYKATSISASVVGKNDGNWYESFVIGAGKNSGVKK
                     ESIVMNGSGLVGIVYEVSNNYSKAISLLDSKASVSFKLAKDANAKGTITQNTTLDNKD
                     SYNSKGYLQGYMFDSSYNVIQGDIITTSGLGFFPDGIPIGEVEKVVDDKDKSLKYVVV
                     KPYVDFKNINDVVVIEPRNIG"
     gene            complement(8145..9155)
                     /locus_tag="KRO40_000009"
     CDS             complement(8145..9155)
                     /locus_tag="KRO40_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBH2090856.1"
                     /translation="MTKDMGIDLGTANTLVYIKGQGIVVREPSVVAIRDDSKEVLAVG
                     EEAKKMIGRTPGNIVAIRPMKDGVIADFDITQSMISYFIQKAADKKGVVSPRIAICVP
                     FGVTEVEKRAIEEAARQAGAKDAFLIEEPMAAAIGAGLKVEEPEGNMVVDIGGGTSEI
                     AVISLGGIVTAKSIRIGGDEFDESIVAYVKKEYNLMIGERTAENVKINIGSTFKDDEE
                     INMQIRGRDLISGLPKTIEICSTEVREALKEPVSSIVDAIKSTLERTPPELASDIMEN
                     GIMLTGGGALLRGLDKLITQETGMSVQIAETPLDCVALGTGKSVEDQEIFEKVLMMNT
                     KN"
     gene            complement(9276..9935)
                     /gene="radC"
                     /locus_tag="KRO40_000010"
     CDS             complement(9276..9935)
                     /gene="radC"
                     /locus_tag="KRO40_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HBH2090857.1"
                     /translation="MAPEERPREKMLAKGVKSLSNAELLAILLRTGNKNKNAIELANY
                     IINRDIQGIRHLEDMTIEELCNIDGIGLSKSTQIKAALELGSRVASFKPIKYKIRNPW
                     DIQRYYMDSLRYLKKEVFKAVLLNTKNEIISDVDVSIGTLSSSLVHPREVFKEAIRRS
                     ASKIIVMHNHPSGSVEPSREDKNITSRLIKCGEIIGIEIIDHIIIGDGLYFSFKENMI
                     I"
     gene            complement(9980..10564)
                     /gene="maf"
                     /locus_tag="KRO40_000011"
     CDS             complement(9980..10564)
                     /gene="maf"
                     /locus_tag="KRO40_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation inhibitor Maf"
                     /protein_id="HBH2090858.1"
                     /translation="MNIILASASPRRKEILENTNVRFDIIKNEIDEIILEGETPKHLV
                     MRLAFEKSMSVASEHNEDVVIGADTVVVLDNAILGKPKDESCARDMLKRLSGREHQVI
                     TGISLINLCEDKKVIDYVISNVKFKTLSEQDIEDYLKTNESFDKAGAYGIQGYGALLV
                     EEIRGDYFNIVGLPISRLGDLLKKYFSINLFYGV"
     gene            complement(10784..11755)
                     /locus_tag="KRO40_000012"
     CDS             complement(10784..11755)
                     /locus_tag="KRO40_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit B"
                     /protein_id="HBH2090859.1"
                     /translation="MVILTAVLVLGIMGLIFGIVLDFASKKFAVEVDERVEAILGVLP
                     GANCGGCGFPGCGGLANAIVEGNAPVNGCPVGGADVGAKVGEIMGISAEAGEKQVAKV
                     ICKGTCSSAKDKYEYEGISDCRAANVLNSGAKMCKFGCLGLGTCKDACKFDAISIVDG
                     IAVIDEEKCVNCGKCKEVCPKGIIITKPESQEVVVECNSKEFGKAVKEKCTAGCIGCG
                     MCVKACKFDAIIFEDKIAKIDPNKCVGCMQCVAKCPTKVISGDITKKKKVTIDQELCV
                     GCTVCKKQCKFDAIEGELKEKHKVDADKCVGCHLCMEKCPKKAIKIL"
     gene            complement(11771..12346)
                     /gene="rsxA"
                     /locus_tag="KRO40_000013"
     CDS             complement(11771..12346)
                     /gene="rsxA"
                     /locus_tag="KRO40_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxA"
                     /protein_id="HBH2090860.1"
                     /translation="MNLILLFLSIVLVNNVITSQFLGICPFLGVSKKVDTAVGMGVAV
                     TFVLTLASIITYFIQILLVKTGTGFLQTIAFILVIASIVQFVEMVIQKMSPSLYQALG
                     VYLPLITTNCAVLGIALVNVQKSYNLVETIINGFGAGAGFTLAIVIFAGIRERLELAD
                     IPEAFKGFPITLISAGLMSIAFLGFTGLIKL"
     gene            complement(12361..12954)
                     /locus_tag="KRO40_000014"
     CDS             complement(12361..12954)
                     /locus_tag="KRO40_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit E"
                     /protein_id="HBH2090861.1"
                     /translation="MNLAKVFKNGLIDENPTFVQVIGMCPTLAVTTSAINGIGMGLST
                     AAVLICANLVISLIRKITPDKIRIPIFIVVIATFVTIVGMLLKAYVPALDKALGIYIP
                     LIVVNCLILARAESFAFKTGAMPSIVDGVGQGLGFTVALTIIGAVRELLGNGSLFGMT
                     LFGASFQPVLIFILPPGAFLTLGFLFAGFNKLRSKKA"
     gene            complement(12967..13536)
                     /locus_tag="KRO40_000015"
     CDS             complement(12967..13536)
                     /locus_tag="KRO40_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit G"
                     /protein_id="HBH2090862.1"
                     /translation="MNSMVRLGGTLLAISAIAALALGATNQVTAPVIEQRNIQANNEL
                     RKAVLPEAKEFKEMKEDTYKGLGDGLIAEVYEGLDGSEVVGYTLKAKPSGYGGEIEVM
                     VGISSEGQVTGVDIGNMSETAGLGAKAKDDAFKGQYKGKTAEPLEVAKGSTTADNQIL
                     AISGATITSTAVTTGVNAAIDVFNSALNK"
     gene            complement(13536..14513)
                     /locus_tag="KRO40_000016"
     CDS             complement(13536..14513)
                     /locus_tag="KRO40_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit D"
                     /protein_id="HBH2090863.1"
                     /translation="MENKLIVSSSPHMRSNEDTSYIMKQVIIALLPAAVAGVYFFRLN
                     ALSAMFFCILGTVGTEFLYQKFTKQKSTIGDFSAVVTGLLLAFNVPASLPWWMCLVGG
                     IFAILVVKMVFGGIGCNFVNPALAARAFLLASFPVAMTAWTQPGVNWIGKNLDAVTTA
                     TPLSFLKNGAAGLADLSSNGISLADMMIGNIGGCIGETSAILLLLGGVYLMYKGIINY
                     VIPVFYIATVFILTFLLGGFNITFAIYQLFAGGLMLGGFFMLTDYTTSPMTKKGQIIY
                     AVLAGLITTVIRMYGGYPEGVSYSILLVNCLAPLIDKFVRNRVFGEVAK"
     gene            complement(14536..15873)
                     /gene="rsxC"
                     /locus_tag="KRO40_000017"
     CDS             complement(14536..15873)
                     /gene="rsxC"
                     /locus_tag="KRO40_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxC"
                     /protein_id="HBH2090864.1"
                     /translation="MKLLTFKGGIHPPYRKEYSNTKALEKAQAPKIVYIPLQQHIGAP
                     AKPIVEVGDEVKFGQKIGEQQGFVSCNVHSSVSGKVIAIEQHEVPGGSAQCVVIENDF
                     KEELHESVQPKGQLEDLSKEDIVGIIKEAGIVGMGGATFPNHVKVSPPPDSKAEVVIL
                     NGAECEPYLTADHRLMVENPEDVVFGLRALMKVLDVKKGFIGIETNKPDAIEAIQNVA
                     KDYSEIEVVGLQVKYPQGAEKQLIYACTGKEVPSGGLPIAAGAVVDNVATAAQIAKSI
                     KTGMPLVERITTITGSCIKEPKNLITKVGTLVSEIIEQCGGFKEDKKIGKVIMGGPMM
                     GIAQYTTEIATNKGSSGILCLDEEESRTPDIQNCLRCGRCTDVCPSFLQPLFISAYSL
                     KDDYDTAEYHRAMDCIECGSCSFICPARRPLLQSIRSAKREIGAKRRKQAAQK"
     gene            complement(16089..17033)
                     /locus_tag="KRO40_000018"
     CDS             complement(16089..17033)
                     /locus_tag="KRO40_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090865.1"
                     /translation="MNRRKTIYRGFNNNRHKIDLRKYVITIACLCLIGYYSYTKIKDS
                     KILEYVSAKIPFLNNSSDITYKDISDELNSIKKGKKSKSQTNSDDKQETNPEKAVNNT
                     KEPEEVKLATIEGWDMYTIQVAAIDNNDDLKKIQTSLVNNDIPFSVMEKDGVKKIQTY
                     SSFDENDVRKQISSVRKVFPDAFLSHLDAPMLSLEYTSNYAYIESISKELNKLITNFK
                     EESSFWSNAENNVDMEKYNTILTNRKAISQNISKEAEKIDYSEMRLFKDNLIEYVKNV
                     NEKIDTASKAANEEKYSVSKSLLLSSMQEYSMFINSIK"
     gene            complement(17144..18418)
                     /locus_tag="KRO40_000019"
     CDS             complement(17144..18418)
                     /locus_tag="KRO40_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH2090866.1"
                     /translation="MKKAIAALGIGAVAVSVSSINASALEKGTVTASALNIRSGPSSD
                     CDKVAKLYKGKTVEILEKSNGWYKVRVSSSVVGWGSAKYISTSGSSEGTSSQNNPTSS
                     GTTISGNGKVNVSSRLNVRSGAGTNYSLVGKANNGDIVKLLEQSNGWYKIKLSNGVTG
                     WASSQYISKTSEDVGTNNSSNSNSTNNSDKKPSSEESIEGKNGKVTSAVSLNVRSGPG
                     TSYSIIGKLNGGDVVELKAKSNGWYKVKLSSGTIGWVSASYISETNEGTKEKPNSSSN
                     QNSQPNSNSKPSFTGNSDKSTAKGSTIVDFAYTLIGIPYQWGASGPDKFDCSGFTQYV
                     FKHSVGVSIPRVSREQANFGSAISMGNYAPGDLVYFDTDGDGTTNHVGIYVGNSKFIH
                     CSGTQTNPNKVKVDNLTSSYWSKVLLGARRFV"
     gene            complement(18550..18921)
                     /locus_tag="KRO40_000020"
     CDS             complement(18550..18921)
                     /locus_tag="KRO40_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2090867.1"
                     /translation="MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILV
                     YLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEVEEFDEAKKLHKDLDCICFENES
                     MGIYFIADPDNYWIEILPKNH"
     gene            complement(19149..19748)
                     /locus_tag="KRO40_000021"
     CDS             complement(19149..19748)
                     /locus_tag="KRO40_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090868.1"
                     /translation="MESRGYKEDLKKMILDMAHKELESYVSQKGAKKYFEGNLDKIIN
                     NNIKKFNQSIGLNRVYLKMLKKCAYQESVTSISRTIKKEALFKSKKELFAFSEYLKLD
                     INKRLSYNQILRKISRYIYYNRSSYAQKYVVFKRGDEEYLLEPEKIKDELISSYRSKT
                     REDMRSIAKLLDIEVEDDYNAEDIRKKVINYIIKEKLKS"
     gene            complement(19949..20161)
                     /locus_tag="KRO40_000022"
     CDS             complement(19949..20161)
                     /locus_tag="KRO40_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy-metal-associated domain-containing
                     protein"
                     /protein_id="HBH2090869.1"
                     /translation="MKKKLLVEGMSCGHCVNHLKTALTEDIDGIEVLDVDLENKCASV
                     DMKDDVSIEKLKEVIAELGFELKGIE"
     gene            complement(20234..21949)
                     /locus_tag="KRO40_000023"
     CDS             complement(20234..21949)
                     /locus_tag="KRO40_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2090870.1"
                     /translation="MKRIKVLTVVLAITLMVAGCSNTKTKQSSSDSSLQSQSSIDAKY
                     INLTMVTPKTINPITNTDKSVGYIMNLVYDSLFTIDENYNVIPQLVKEYNIAQDGMSI
                     DIKLKDAKWHDGKNVTSNDVNYTIGLIQKSADSPYNEFTKNIASVNIKSDKDFTIKFK
                     ARYAFSIDSLIFPIVSQNHLDSKDVNDKNNNMIGNGKYKIESYTEREGMVLSVNKDYY
                     EEVPKTMKNIKVGMVPNEDARTSMVMALDSDITNVTLNDLSKFQEKEFNITKYQGRDY
                     ECVLFNYNNPFFKDVNFRKAIAHSIDKDRIISEGYMDDATPVNFPLNSKSKYYNSEMK
                     DLEFNKDKAIECLAKVEYANVNSVNQNDNKVKNQKKSAKKNSKKLTPEEEAKAKKAEE
                     DRIKKEAEEKKNREKEEVKKSLSEMNLKIIVNRDNSERIKTANIINENLKAIGINSTV
                     NQLSDKDMENALNSKNYDLALVGWKLSIIPDASSIIASSGYTDDKLNGYMSALTSSTS
                     EIETKKAYKDVQTYIKDNATFISLAVRNNYIVSNSRLKGKITPNDFDVYEGISNLDIK
                     SNESN"
     gene            complement(21949..22503)
                     /locus_tag="KRO40_000024"
     CDS             complement(21949..22503)
                     /locus_tag="KRO40_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBH2090871.1"
                     /translation="MNSKKVLILSIFIILFGALLMESKVIHKFLYPKKYSEYVEKYSK
                     EFNLDENIVYSVIKAESKFNSSAVSKKEAKGLMQILDITRDWGAEELNLKNVDIFDPE
                     TNIRLGCWYLSKLYKEFGKLDLVIAAYNGGSGNVKKWLENNEYSKDGENLHDIPFKQT
                     SKYVEKVKNNYEHYNKIYGKKGKN"
     gene            complement(22496..23098)
                     /locus_tag="KRO40_000025"
     CDS             complement(22496..23098)
                     /locus_tag="KRO40_000025"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HBH2090872.1"
                     /translation="MLILGLTGGIGCGKSSLSNIFRNLNIPIVDADIISRKIFEDKLL
                     LEKVFVHFGQSIKNDDGTLNRKALGKIVFSDEEKLKELNNLTHPRIREKIISEIEKLR
                     KKGENIVVLDAAILVESGFLDMVDKLLVVTCKQEVQISRIQKRDNCSEQEALSRINSQ
                     MSQEEKSKYGDYIIDNSGTITELESKAHKFIEYMKENWRE"
     gene            complement(23107..25755)
                     /gene="polA"
                     /locus_tag="KRO40_000026"
     CDS             complement(23107..25755)
                     /gene="polA"
                     /locus_tag="KRO40_000026"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HBH2090873.1"
                     /translation="MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFK
                     MIDIYKPTHISVAFDRKAPTFRHLEYKDYKAGRKGMPDELAEQLQPLKDLLDKFRINR
                     LEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY
                     NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENT
                     DKLKGSVKKKIEENKEIAIQSKRLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFG
                     FTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQVILKTVRGQGNILE
                     KNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLEN
                     MYFDITIAEYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDL
                     AEYMGQIICTVKETVPMMERSLMDMSMDGLFYHVEMPLVEVLGHMEYEGIKVDKSILD
                     ELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTGYSTNAD
                     VLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRIS
                     STEPNLQNIPIKMEMGRKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFK
                     HHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIYGKSDFGLADDLNIPVPKAKE
                     YIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAM
                     NAPIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKE
                     EMENAVNMDVHLDVDLNVGSSWYETK"
     gene            25907..25994
                     /locus_tag="KRO40_000027"
     tRNA            25907..25994
                     /locus_tag="KRO40_000027"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:25941..25943,aa:Leu,seq:caa)
     gene            complement(26181..26624)
                     /locus_tag="KRO40_000028"
     CDS             complement(26181..26624)
                     /locus_tag="KRO40_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090874.1"
                     /translation="MKKNMLYVGIIYFICGILLVLLATFTEFSFEAFIWGLSGAALGP
                     GVCMILQYMYWSKPERAVDYEEKIKNQRIEMNDERRIMLRDKAGRITNQIMCYVLVIL
                     IFIVSILSVFSVMVISKWVLVVLGLLILFQFICSVVVYNKLDKRL"
     gene            complement(26627..26824)
                     /locus_tag="KRO40_000029"
     CDS             complement(26627..26824)
                     /locus_tag="KRO40_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004631111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2090875.1"
                     /translation="MKNRLEEIRKERGIKQEELASILQVSRQTIGSLENGRYNPSIIL
                     AFKIARYFDMSIEEIFIYEEE"
     gene            complement(27016..27882)
                     /locus_tag="KRO40_000030"
     CDS             complement(27016..27882)
                     /locus_tag="KRO40_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2090876.1"
                     /translation="MEWINKLNQAITYIEENLESGVDYAEAAKIACCSTFHFQRMFSY
                     IAEVPLSEYIRRRRMTKAAFELQNSNIKILELSEKYGYDSPTSFNRAFQNIHNISPSA
                     ARAKGVVLKAYPKMTLSIYVKGNIEMQYRIVEKKGFRIVGIKESMNMIVEECFEKVPK
                     LWAKCIKNGTIDKLSELINNEPCGLLGVSVCTNSKGLDYYIAAPTDKPVLEDTHEYLI
                     PSGTWAVFECVSPMPNALAIQELQKRIITEWLPSSGYVYANLPDIELYPNGDINAPDY
                     TTEVWIPIQKPS"
     gene            complement(28108..28977)
                     /locus_tag="KRO40_000031"
     CDS             complement(28108..28977)
                     /locus_tag="KRO40_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2090877.1"
                     /translation="MDYKTIILNRKSVREYKNTDIKEEYLSEIKKYSESCKKLVPEID
                     VDVRIMNRSEVFNNLDKVAGYKGNMIDSPSYIIILSDIKDNYIENSGYIGESIIFKVT
                     ELGIGSCWVTFEDGKKVKEKLGINSDKEVTGIIAIGYGENVSNAKVLNATKTGQNYSK
                     SDMQVVTDKGSTRLGVEDVVYMNEWGNVASIEILEERALLDAFHYARLAPSTLNRQPW
                     RFIVDGGTVVLAVRKDGHTNLYEEKIDIGIVMLYFATIISATMFDLKWNLGTPDKDYK
                     VPEDYKIVGYCNI"
     gene            complement(29483..29704)
                     /locus_tag="KRO40_000032"
     CDS             complement(29483..29704)
                     /locus_tag="KRO40_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090878.1"
                     /translation="MNVNNHKCPECGEHSKKFEIVEENEDCVIFECYTCGTISILKYC
                     ENCKEFVFVNIPNNVETYEYCCGKCNNKI"
     gene            complement(30206..31186)
                     /locus_tag="KRO40_000033"
     CDS             complement(30206..31186)
                     /locus_tag="KRO40_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090879.1"
                     /translation="MGDTSRFYESVKNKYPKLKDGTRVHLWPKENIIIGPIYDEEDGY
                     KKSIGNVDSLSWKQIVILAECDGKNTTDDIINILSNRYRNIHNMKEKVMEFFMFYENV
                     YLTFEDDIQTLSSVFEITGNKSYITPLYFTIEIDGDNNTNDYFSEITSLLNCMYEKGC
                     RFIEVIGEDILKNKSMREIFQYMLDHFDLIVVTKDSFTIDRSLIKELDNYRHKVIWKV
                     YSKNDDTRIKLKEDIKITSLIKRGHTVVRGDREKAIKIEDMRFKDTKERFSKYGAEWS
                     HLYISSDGSVKSYSFQKDKRIYLGNIFNNSVEEIFLEMQNKIDKLEIVYQ"
     gene            complement(31350..32222)
                     /locus_tag="KRO40_000034"
     CDS             complement(31350..32222)
                     /locus_tag="KRO40_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2090880.1"
                     /translation="MIIKVSMTVLVLILLYILYKYETQHIETTEYTIFNKKIPKEFDN
                     FKIVQVSDLHNKVFDKNNKVLIDKIESLNPDVIFITGDLVDGENKNFQVALDLIDNLV
                     EKYEVYHIIGNHEQKSLIKKYKHLYKDYFKELYSKKIINMENESVRIYRGNSHLNLYG
                     LIIPLECYPYLFANNKKLELSDNFVEDNLGKVNENEYNILLAHTPFFFEKYAKWGADL
                     VLAGHVHGGIIRIPFVGGVLSPNREFFPKYDWGKYEKDNSTMILNKGLGGSKVLIRLN
                     CKPEIVKITFKYEK"
     gene            complement(32386..32937)
                     /locus_tag="KRO40_000035"
     CDS             complement(32386..32937)
                     /locus_tag="KRO40_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2090881.1"
                     /translation="MDNKFPNVGENLRLLRQEMGISLDKASKMTGVSKAMLGQIERGE
                     SSPTVSTLWKISSGFKINFTTLLNENTNTYEVIKKEEVEPIVEQKGNMKLYPIYPFSP
                     QRRFELFIIELEENCTHVSSTHSHVLEEYVLVIEGKLDLNVDGKTYILESGHSIRFDG
                     TLEHIYKNLNKGKTIFHNIEVYR"
     gene            complement(32957..33859)
                     /locus_tag="KRO40_000036"
     CDS             complement(32957..33859)
                     /locus_tag="KRO40_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBH2090882.1"
                     /translation="MSKKGRVVKVQHFSVNDGDGIRTTIFLEGCKLKCKWCSNPDSWS
                     NIVKLGVMKDKCVSCNRCIDVCPQNISSLFDRAQINNKCDLCGECIKVCLKDAICIMT
                     EEMSVEEIVEEVEKDFIFFFESNGGITFSGGEPTLQIDFLRELVDIFYDKGINIAIET
                     CGYFDWNKVNDVFEKIDHIFVDIKSMDDNIHKEYTGVSNKIILDNICRLSKLNKSMVI
                     RVPIIYGVNDSEENIRNTALFVKQNVPGGKMELLPYHKFGIDKYKALGLEDYIYEFDE
                     ICNNHMLKLKEIVELTGVKIIEYK"
     gene            complement(33874..36246)
                     /locus_tag="KRO40_000037"
     CDS             complement(33874..36246)
                     /locus_tag="KRO40_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase/glycerol dehydratase
                     family glycyl radical enzyme"
                     /protein_id="HBH2090883.1"
                     /translation="MSQTNRIEAFRQEYINSKPMICCERARIFTESHKKTEGEAICIR
                     RAKAFLETCKELPIKIFENELIVGTAGKFRRTGILTPEFSWQWVDKEMDTFDKRTQDP
                     YVISKEQIEFIRKEIFPYWKGKSLEEVFLARIPEDTAKILVDTGIIDNDSKWRQAVGE
                     VTPDYQDILFVKGYKGIKEDADKKIKELDISVSENIEKIDFYKSVSIVAQGIMTLAQR
                     YSNLAKEMSKQETDEKRKLELIKISEICMNVPANPPTNFYEAIQFVWFVQLGGILSEN
                     PLALNLGRFDQYMYPYYENDAREGKITESEAQELIEALWIKLSEWVWTISANTANYFA
                     GYNQFQNLTVGGKKRNGTDGTNDISYMCLKATESVKTHQPGLSVRVSQGAPDNFVMAV
                     AKLVKQGTGFPAIHSDSAGAQMLLQDGYDAEDARDWSNCGCVVPHFRKTGQWTSAVNI
                     NFAAALEYAMNEGKSRLTGEKMGLDTKNITEFTSFEELKDEFLKQLAYLVKSSVIGTT
                     VAQQIHKEMVPRPFLSTCVDGCLDKGVDLSKGGAKYNIGPVLTGIGLGVVSNSLAAIK
                     KLVFEDKVTTLEELTKALNNDWEGYEELRKLALDVPKYGNDNDYVDSLAIEVSDFYYT
                     ETRKYKDIFGSKFNSAFMGISNYVPTGKIVGATPCGRKATKPLTEGVSPFVGTDTTSP
                     LAAMKSASKINHDVHTGGTLLNLRLNQDLVETERGLRNLTSMIKSYFALGGFHVQFNT
                     ISNDTLLKAQENPEEYKDLLVRVAGYSTQFVNLSREMQDAIIARNSHSNF"
     gene            complement(36467..37156)
                     /locus_tag="KRO40_000038"
     CDS             complement(36467..37156)
                     /locus_tag="KRO40_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2090884.1"
                     /translation="MKVKRNINRVAIIVALNLSLALMVGCMSPVSDKNLSSSEQISKD
                     SLKEQVEDKKDESIELFNNYSQKINDAKGREEVKKDLSQRFSKAIIDSGYSITNSKSD
                     GSFVVSINGAEKPPEKNIRSLFYSMSEDDKEGKVTIDILCAKEYPEDDKLSESDKYVK
                     FIYNLFKSLTDTNLTEKEIFSMVEEDFNKGVGVVELPYMKDIHVEVNKVKQSTKVLKL
                     SLVYKFDISNH"
     gene            complement(37397..38776)
                     /locus_tag="KRO40_000039"
     CDS             complement(37397..38776)
                     /locus_tag="KRO40_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2090885.1"
                     /translation="MLNFMTELLVVLSIFIQFSIMNGILIYKKDSKKNEKIVFYIVLF
                     LIYIIIQISRLFNGGNYFSNINYLFYILAFIAWGGYYNYFYKMGYIKYSIFFYLFSVY
                     YKCLDAVIYRILFFAITGNVISSKESLLVPYLESIKIQIYSNLIIILIYLIFSFFRKS
                     IKLISQDKRNYVYLLFALLVNTMNMLVNYVLKKLERFGSLHSEGYYFDNFVNPKLVGA
                     SSIFLILLFKEIIKENRLKSQAELIKNKLDMQYAHYLSIQESHMRVKKLYHDINNHIY
                     CIDNLRNNSKEINEYVNNLKDEIKTFKYIYNTGNMILDIIINEKSEVCLKKGIKFTCS
                     INFSKVNFVKPIDVSSIFSNILDNAIEACDKIVDENINKYIRIKGTITRSFFVLKCEN
                     SKLNQLTFNKNILLTNKMDKFVHGIGIQSIKSSLQKYNGELLFENSIDKFILNIYIPL
                     DQDTDSWGD"
     gene            complement(38770..39483)
                     /gene="rgbR"
                     /locus_tag="KRO40_000040"
     CDS             complement(38770..39483)
                     /gene="rgbR"
                     /locus_tag="KRO40_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RgbR"
                     /protein_id="HBH2090886.1"
                     /translation="MIKIAVCEDEKETQLLIEDYLENILKDISIEYEIQKYISGEELL
                     ESNLKDIDILLLDIKMEKLNGMDTARKIREVDNEMEIIFVTSLIDYVQEGYEVRAYRY
                     LLKPIELEELKKHVLTCIKDIEINKESHITIKNKSNTYKIYLNEIKYIEVQKKDMLIH
                     TINKNFDIKYSLGKIEKELNPYKFIRCHKSFIVNLRYVENIKPNTAILESGEEVPISR
                     YRYKEVKEKFLKFLGDTIC"
     gene            complement(39733..40293)
                     /locus_tag="KRO40_000041"
     CDS             complement(39733..40293)
                     /locus_tag="KRO40_000041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HBH2090887.1"
                     /translation="MSAMEKKIKFKFDWYSSPDKIEKWLEDIEAKGYNLYKINKFGGI
                     FYFHKGSPRKIKYTVDYYYDVENNYFDEHKSNGWNLVFRSIGSFMGTSAWYIWSKEYK
                     DIPPKLYSDSDKTNKVKSILFMNMFIFFMLVVIFIYLLNIEIRNLYSGYGASVTAIVL
                     QIILLILYAVQLYRRLMYYLRLKKFK"
     gene            complement(40388..41191)
                     /gene="zupT"
                     /locus_tag="KRO40_000042"
     CDS             complement(40388..41191)
                     /gene="zupT"
                     /locus_tag="KRO40_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter ZupT"
                     /protein_id="HBH2090888.1"
                     /translation="MNNVIFAFLITLLAGLSTGIGSCIAFFAKKTNTKFLSISLGFSA
                     GVMIYVSMIEIFPKAQDALTKSMGEKLGSWSTVIAFFIGMAIIAVIDKLIPQEENPHE
                     IKKMENIEEKNIKKNKSLLRTGIFTAMAIAIHNFPEGLATFISALDDVTIAIPIAIAI
                     AIHNIPEGISVSVPVYYATGDKKKAFYYSFLSGMSEPLGAIIGYVLLRNFLNDITLGI
                     VFAIVGGIMVFISLDELLPSAREYGEHHLSIYGLIAGMGVMAISLLLFK"
     gene            complement(41342..42505)
                     /locus_tag="KRO40_000043"
     CDS             complement(41342..42505)
                     /locus_tag="KRO40_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2090889.1"
                     /translation="MDIKEITKSYKDYVIKLRREFHENPEKSMEEVRTSKRVKEELDK
                     IGIPYVSAGGTGVIATIKGANPGKTVALRGDMDALQVVECTDVEYKSKNEGLMHACGH
                     DGHTSMLLGAAKVLNDIKDSINGTVKLFFQPGEEVGKGARAMIQDGAMEGVDSVFGIH
                     LWTDVESGTISVEEGPRMASADFFKITVKGRGGHGSLPHQGVDAVLASSAIVMNLQSM
                     VSREVSPLEPLVVSVGVLNSGTRFNVIASEAILEGTIRLFNPELRKQIPRILERIAKS
                     TAEAYRADAELEYGYLTPAVINDKECSKIATDAAIKLFGEDCITLFEKVTGAEDLAEF
                     MNIAPGALAFVGARNESKGACYPHHHGCFNIDEDALEIGTALYVQYAVDFLNK"
     gene            complement(42565..43752)
                     /locus_tag="KRO40_000044"
     CDS             complement(42565..43752)
                     /locus_tag="KRO40_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090890.1"
                     /translation="MEAITAFCLVLVSLTIGDIVSAKTKAFVPSVFVSAIIFIVGFWT
                     FFPENIVDLAALGTPLAQLGMLLLITHMGTMMSIKELAGQWKTIVIALAGIVGICVGA
                     LALGTVVFGWDTAVIATPPLTGGLVASIMMADAATAKGLASLSVLAILMYVAQGFAGY
                     PITALMLKKEGKRLLSDFRSGKVTVNTDEEKVKDLPEQKSRFKIIPDLPEKYDTTYMI
                     ILRLGFVAWLAVQFTNLTNEVVSRYVICLIFGVIASELGIVDRKPLNKSGSFGWLMTS
                     LMAFIFAGLAKATPAMLVEMAVPLVGIIIFGVIGMGIFSIIVGKLLGESKEMAFSVSL
                     TSLYGFPPNYILTEEAVKALAETPEEKEFLMDKMLPKMLVGGFTTVTIASVVIAGIFV
                     NLI"
     gene            complement(44115..45815)
                     /locus_tag="KRO40_000045"
     CDS             complement(44115..45815)
                     /locus_tag="KRO40_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2090891.1"
                     /translation="MIKQFVKYYKPYKKIFTLDLIAAFLFSLCDLVYPMITRNIMDDV
                     VPNKNLRMLVVFAVALILIFIAKAGLNYFMQYWGHVIGVDMQADMRNEVFTHLQRLPN
                     TYFDNNKSGVTMSRIVNDLMDITELAHHGPEDLFISIVMLVGSFFILIDINIPLTLII
                     FAILPFIIWFAIAKKDKMNIAFMKSRVTIGDVNATLENSIAGMKVTKSFCTEKEELNK
                     FVRSNKLFRRARQDSYKVMAEYYSGMNLYMDILEWVVVIAGGYFTYIGKITLGDFAAY
                     ILYVKMFIQPMKKLINFTEQYQNGMTGFKRFIEIMEQDHQKEAKNPIELENVKGDIEI
                     ENISFTYEDKTQVLDNLSLSIKAGKTIALVGPSGGGKTTLCNLLPRFYEFDKGDIKID
                     GKSIKDVSLKSLRKNIGIVQQDVFLFTGTIRDNILCGNPNATDEEMIAAAKKARIHDF
                     VETLPDGYDTYIGERGVKLSGGQKQRISISRIFLKNPPIIILDEATSALDNVTEREIQ
                     ESLEELSKDRTNLVVAHRLTTIKNADEIIVLTDKGIEERGTHEELVNKNGVYSRLHNN
                     "
     gene            complement(46070..46345)
                     /locus_tag="KRO40_000046"
     CDS             complement(46070..46345)
                     /locus_tag="KRO40_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2090892.1"
                     /translation="MKKILVACGAGIATSTIVCDRVERLVKENNIQAEVEQCKIAECS
                     TKQEGADLIVSTTILPTTYDIPTIKATGYITGINTTALDKKILNALK"
     gene            complement(46464..47036)
                     /gene="mobB"
                     /locus_tag="KRO40_000047"
     CDS             complement(46464..47036)
                     /gene="mobB"
                     /locus_tag="KRO40_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-guanine dinucleotide biosynthesis
                     protein B"
                     /protein_id="HBH2090893.1"
                     /translation="MLLLDSFMKGHNFMYNILSVVSYSGVGKTTLIEGIIKELNKKGY
                     RVGVIKHTCHDFDMDEEGKDTYKHRKSGARKVCIISDKRVAYIEELKEKNPLYKMIQL
                     YEDMDLIIIEGYKNYRFKRLEVTRKGKYEDILSNKSDLIGIVSDIEYKLNIEQFNLND
                     YKNISKYIESCIKNEILSISNVEIKNILKE"
     gene            complement(47020..48201)
                     /locus_tag="KRO40_000048"
     CDS             complement(47020..48201)
                     /locus_tag="KRO40_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin molybdotransferase MoeA"
                     /protein_id="HBH2090894.1"
                     /translation="MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDS
                     PPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNRVLNKNEAVKIMTGGKIPQGANC
                     VIKKEDVTVIGDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
                     ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNC
                     SDDILDLEKKVKNMLQSVDFLITTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGA
                     CYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHHIKAIFKGEFNKLSN
                     KDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVI
                     R"
     gene            complement(48412..49146)
                     /locus_tag="KRO40_000049"
     CDS             complement(48412..49146)
                     /locus_tag="KRO40_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090895.1"
                     /translation="MKLKRSLVCVTILGIILVGCHKENTKEKNQVASKATQQKTMTKV
                     QNDVNEIMNKDYKYIIKNMGIPYNTFYYIKPKVLKESNTMQDINTSSYMTLVYPKYTG
                     NDELDGSALYVDINENKVVNVETNSFSSQGISVIDAESSIVIEKSDHEKSAVSLENFR
                     HIDLGEYVGVEDSRINEIVGDANYDLTAYNHEGSKVVKSYRLKEDNKILKKEVLTISI
                     VDNKIKSIKTIESDKIVKIIKGTLLE"
     gene            49508..50413
                     /locus_tag="KRO40_000050"
     CDS             49508..50413
                     /locus_tag="KRO40_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2090896.1"
                     /translation="MDFKQLEVFVAVAKHQSFSKAARELFLTQPTVSAHIQNLERELE
                     TVLINRSNKVITLTKSGEILYEHAIYILNNCKRAIYDIKEYSGKIEGIIDIACSSIPE
                     TYILPDFMKSFSMSYPDVKFSISHYDSQYAISEILNERISFGLVGSKINNPQIEYLDL
                     LDDELVLITPSDFKIDNKNNCIDIGELAYLNFIMRKEGSGTRNLILNTLSKNNFPVSK
                     LNVIAHVESNEAIKEMVRLGLGVSFISYISAIDYLNAGKIKCYKIKDVDFTRKFFFIY
                     SKKKTFSPLEDKFLNRLCEYFEIII"
     gene            complement(50573..51415)
                     /locus_tag="KRO40_000051"
     CDS             complement(50573..51415)
                     /locus_tag="KRO40_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH2090897.1"
                     /translation="MTTSSKKLETISPDSKITRKDFWKCFRRSLTLDSSWNYERMQNI
                     AYAYMMAPIIRRLYKDDKEKKSKALKRHLEFMSVTPHISTLLVGISGAMEEENAKNKE
                     FDANSINAVKSSLMGPVSGIGDSFFWGTLKLIAAGVGIALASQGNIMGPILFLLIINV
                     PHFIIRYICLDKGFKYGTQFFKDVSGSSIVSKVMEAASMLGLMVIGGMTASNVMLKLS
                     VNVGSGEWAEPIQTYLDQIMPCMLPAMIFGIMYWLLGKKVKTTTILISVMIICIVLAA
                     IGVV"
     gene            complement(51399..52157)
                     /locus_tag="KRO40_000052"
     CDS             complement(51399..52157)
                     /locus_tag="KRO40_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2090898.1"
                     /translation="MEFTQVILITLIAFFAYMHSFVGSTMHNRPIVVAPLVGLALGNL
                     HTGIVIGSTLELVFMGAFPVGASNPPDFVSGSIIATAFVILTGQDVSAAVVLAVPIAT
                     LVLLIDNFLMTVVLTWGAHIADRYAEEGNIEGVERVQLLFGIGNKLILAIIVGIGFSL
                     GVPVIEKILSFIPSYVTHGMDVAAGVIPAIGFAMLARMMLNKKTVAFLLLGFILVAYL
                     NITVTGVALFGLAIALIYVNFVGEKEVIVDDNEF"
     gene            complement(52174..52644)
                     /locus_tag="KRO40_000053"
     CDS             complement(52174..52644)
                     /locus_tag="KRO40_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2090899.1"
                     /translation="MIKLVRVDHRLIHGQVAFTWTKFLSTDCILIASDDLLKDELRMA
                     GLKMAKPSNVKLVMKSIADSIKALNSGVTDKYNLLILCESVEDVYRLAKEVKAIKSIN
                     LGGTKSDDNRENISKAVHVSKDDIKMIKELDSEGVNVFVQLVPDDDATNVMKLI"
     gene            complement(52644..53387)
                     /locus_tag="KRO40_000054"
     CDS             complement(52644..53387)
                     /locus_tag="KRO40_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane biogenesis protein"
                     /protein_id="HBH2090900.1"
                     /translation="MKKKGILSVFKSKKPIIAMIHLKGDTPEDIFERAKKEITIFEEN
                     GVDGIMLENYYGNYYDLERILEYVSKANLSIPYGVNCLNVDTMGFELATKYNASYIQV
                     DSVVGHVKPRDEATLEEFFKLQRSKCPAYLIGGVRFKYQPVLSENDVEEDLKIGMTRC
                     DAIAVTENATGQETSMEKIELFRKNLGDFPLVIAAGVTLENAKKQLKLGDMAIIGSYF
                     KDNYKDFGDVSVEHVKTFMDEIKKIREEL"
     gene            complement(53391..53804)
                     /locus_tag="KRO40_000055"
     CDS             complement(53391..53804)
                     /locus_tag="KRO40_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2090901.1"
                     /translation="MKKIILASHGDFSKGLLNAVKMIVGDLADCVSSYGLYPGQSASD
                     FALELEKTISEDKECEYIILSDLYGASVCTAMLRLTNLHNVRLFSGMNLNMVLELLTR
                     FSDELTVEDIDQLVEESRRGIQSVTLQIKEEEEVF"
     gene            complement(53830..54582)
                     /locus_tag="KRO40_000056"
     CDS             complement(53830..54582)
                     /locus_tag="KRO40_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2090902.1"
                     /translation="MDEKRQKKEMDLEVNSFVPLYQQLYDNIKKQIASGIYKPGDKLP
                     SEGDLCKEFNISRITVRNALNELVKEDILCKKRGKGTYVTIPERIEATCAGNSFTNSC
                     HRINAKPSTKIISVLIKKADKQVAEALSIELEEKVICIKRLRLIDEVPVIFEVDYFRI
                     DYMFLLKEELEDKSLMEVISNNISTLPKRVENIFEVKHSNKEYSDHLKCASNMPLLKV
                     RQSVYTENNDVLYYNEQFIRSDKYKYAVSAEI"
     gene            complement(54822..56216)
                     /locus_tag="KRO40_000057"
     CDS             complement(54822..56216)
                     /locus_tag="KRO40_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH2090903.1"
                     /translation="MNLKYEFKNAWDFERKENTIEQIMQYSRNYMEFLSKSKTERLSV
                     KEIIKLAKENNYISIDEAMEKGSISCGDKIYVINKEKAVALFVIGKNYIEKGMKIIGS
                     HIDSPRLDLKPNPLYQESNLGFFKTHYYGGIKKYQWTAIPLALHGIVILNDGTKVDIS
                     IGEEDSDPVFCVTDLLIHLAGDQMQKKLSEGISGEALNILIGNIPLEDEEKEPITANI
                     LKILNEKYNIVEEDLLSAEIEVVPAGKARDLGLDRSMVLGYGHDDRVCSYAAVKAILE
                     TEQPEFTSVALCVDKEEIGSKGNTGMHSKFFENTVAELIALEGDYCDIKVRRALANSK
                     VLSADVSAGYDPNFGEAYEKRNSAYMGNGVVLTKYTGSRGKSGCNDANAEFMSEVKRI
                     FNKGNVVWQTAELGKVDQGGGGTIAHILANQGAEVIDCGVGVLNMHAPHEIVSKVDIY
                     EMYKGYKAFFNINL"
     gene            complement(56236..56445)
                     /locus_tag="KRO40_000058"
     CDS             complement(56236..56445)
                     /locus_tag="KRO40_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 domain-containing protein"
                     /protein_id="HBH2090904.1"
                     /translation="MFDKKKLDRINELAKKNKEGILSADEIKEREILRKEYLENFRAH
                     FRSRLDSVKVVSPEEYEQYMKNNKN"
     gene            complement(56474..57919)
                     /locus_tag="KRO40_000059"
     CDS             complement(56474..57919)
                     /locus_tag="KRO40_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2090905.1"
                     /translation="MEKYRIDLNEKKSTKYIQIFNHIKELIINKELVEHEKLPPIRKL
                     SNFLQVNNTTIVKVYELLENEGYVYKIIGSGTFVSSLNSYKSGIDNRKNKIIVQREDL
                     IHFDNGNPSNDMFPIDSFKNAVNMALSKDGSSIFEYDEGLGSEELREKMVEYLSDGNI
                     KTTKENIQIISGAQQGIDIVCKGLISYSDVVFMEEPSYNGAIEVFKSRGAKIISIPML
                     DDGIDIGILKLKLEKIKPRLIYIMPNFQNPTGISYSTYKKKKLIELAEEHDFYIIEDD
                     FISDFVFESKDNRTIRSYDDKNRVVYIKSFSKILMPGLRIGIVEMPNELLKKVLWAKY
                     SSDISTPGLIQKSMYYYMNNFDWKNYLSHIEKIYTDKYKLAKNLINDKLSGKLKVRKS
                     CGGINFFLELPRGYTSQAFTNFMLNKGVSMLPGTYFFDNLVDDRFFRINIARPSMEEL
                     EKGISIISDNIDEFFCEYKNKLDIKSNKLFY"
     gene            58029..58823
                     /locus_tag="KRO40_000060"
     CDS             58029..58823
                     /locus_tag="KRO40_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBH2090906.1"
                     /translation="MFYDYHMHSSFSTDGKSTMEQMVKKSIELGLEEICFTDHVDYDV
                     YADDSFSIVYEDYFKSLETLQSKYKDKISIKKGIEFGVQTQLMDTYKKEAHQYPLDFI
                     ICSIHAIDTMDLYLGNYFKDKTQHEVYENYYLYLYNIVKNYKDYSVLGHLDLIKRYAP
                     YDTVLDDRLFSDIIEETLKQAIYDGKGIEINTSCYRYNLPDLTPSKYILQMYKDLGGE
                     IITTGSDSHHISQVACEFDYIYSLLKNMGFKYVSKFNKLKPEFIKL"
     gene            58874..60196
                     /locus_tag="KRO40_000061"
     CDS             58874..60196
                     /locus_tag="KRO40_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH2090907.1"
                     /translation="MKVPYLVLSTVILFISNFIVRIFGFLYKIFLSRALGETGLGIYH
                     MIFNFLMICLAVTTTGIPTALSCLVAKRKALNDRHNTNALFISTLYISFFVALIISIV
                     ASFNSSFLSLKFLKDAKLNLFILAVCPAIVIITLSNVLRGYYYGIKNVKIPAIGQIIE
                     QIGKILFVFLLVMYINNKSMNCYIALLGISIGELSNIIFMLICLWRDSSFDNRYIISI
                     KDFYNSSMETLKMSIPITCNRMSNILLQSISSMMIPSRLALSGMTYQQSLSMYGIVSG
                     MVMPFIFLPFTVGSALIVNLIPTISQEMALRKRKSVIKKIKYSILLTLFVGILSSIFF
                     YFFGKDLCILVFKNTLAGEYLKAMFLVPLFMSLNQTLSGILHSIRKELASSINTITGM
                     LIQLIALYVFLPIPGLNIYAYIYTMTIVSIFTCLLHTIVLFKSLKSIR"
     gene            complement(60296..61513)
                     /gene="cdeC"
                     /locus_tag="KRO40_000062"
     CDS             complement(60296..61513)
                     /gene="cdeC"
                     /locus_tag="KRO40_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeC"
                     /protein_id="HBH2090908.1"
                     /translation="MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHN
                     GCNTDNKCECHDDCNPCNPCNPCKPNPCNPCKPNPCDDNCGCHDNCKCDCEPCEMDSD
                     ECFENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFE
                     TEVVEVFGSVPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETT
                     FEFAVCGERNSECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVR
                     AGGGCKRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNE
                     CCEPFYELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQC
                     GPNHGSGKPSCHR"
     gene            complement(61696..61876)
                     /gene="ssrS"
                     /locus_tag="KRO40_000063"
     ncRNA           complement(61696..61876)
                     /ncRNA_class="other"
                     /gene="ssrS"
                     /locus_tag="KRO40_000063"
                     /product="6S RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00013"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00013"
     gene            complement(61991..62896)
                     /locus_tag="KRO40_000064"
     CDS             complement(61991..62896)
                     /locus_tag="KRO40_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090909.1"
                     /translation="MNNLLFLIGVIALSNGNISIFDDKNKSKGNNRVRKNKKNANDKL
                     SQSTHGNLRFDANDIKRGLRLMDLSEEDLEMGMEIITRTKKYMSRDERKILIKIESVL
                     DLVRGIKKLNNIDMVDTEDETDFFRKMDSDDKKNMMIKEIIDVFPEKRKNSVEKAIGM
                     KKKIDLFAELFLPDDFGEGGFSLSSLANINNLGSMNNLKLLGSLLRGDDSNNDDEDNN
                     DELNYEDEELDCEDKELDDDELTDEGEMEDNEDELVEDKNTGYENIENDEDIVYDEEL
                     YNINEQESEYNYNEKNTKTRAKKKR"
     gene            63108..63506
                     /locus_tag="KRO40_000065"
     CDS             63108..63506
                     /locus_tag="KRO40_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090910.1"
                     /translation="MKKLDTESLEKMAKQKNIDKDKIEKMADSYKGKSENELMEELIK
                     IGKNLDGRDEVVSKFKAFLDENQRKKLDNIMEKISDAENQRDTKPAKTKKAKPTKGKS
                     NSPAPKNTPGSQQKKSKSLFKKTKKSNPHE"
     gene            complement(63629..64645)
                     /gene="ccpA"
                     /locus_tag="KRO40_000066"
     CDS             complement(63629..64645)
                     /gene="ccpA"
                     /locus_tag="KRO40_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family transcriptional regulator CcpA"
                     /protein_id="HBH2090911.1"
                     /translation="MKGNITIKDVAKQAGVSISTVSRVINDSKPVTDEVKQKVLEVIK
                     ETGYIPNPLARSLVTKKSQLIGVIVPEVSDSFVNEVLNGIEEVAKMYDYDILLANTYS
                     DKEQELKSINLLRAKQVEGIVMISWIVEQEHINYIQNCGIPATYISKTARNYDIYTVS
                     TSNEEATFDMTEHLIKKGHEKIAFIMTSKDDTVLEMERLAGYEKALSNNNIELDKSLI
                     KYGGTDYESGYNSMKELLDDGIIPHAAFVTGDEAAIGAINAICDAGYKVPEDISVAGF
                     NDVKIARMYRPKLTTVYQPLYDMGAVAIRMVIKLINKELIENKKIELPYRIVDRESVT
                     ERKK"
     gene            complement(64898..65098)
                     /locus_tag="KRO40_000067"
     CDS             complement(64898..65098)
                     /locus_tag="KRO40_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090912.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFEDCWRDIDIMSWIPF
                     LILLLITCSCGGFFDGEVGCGC"
     gene            complement(65132..65311)
                     /locus_tag="KRO40_000068"
     CDS             complement(65132..65311)
                     /locus_tag="KRO40_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090913.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFGDSWAEFDIMAWIPF
                     LIVLLILCCCGGCLE"
     gene            complement(65493..65699)
                     /locus_tag="KRO40_000069"
     CDS             complement(65493..65699)
                     /locus_tag="KRO40_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090914.1"
                     /translation="MTKLEDNMERFFGGCEGFFGNKMLIIIVIVFLLLCTDILEDLLC
                     DDNIWIWVILIVLLLFNFDDGCCC"
     gene            complement(65747..66172)
                     /locus_tag="KRO40_000070"
     CDS             complement(65747..66172)
                     /locus_tag="KRO40_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090915.1"
                     /translation="MKYVGLLLTSVGMFLLIAVNFYYNSITLDMQRIEDYVMETNLIL
                     EDVAEKESYVSNEKEDYISRLMHVKKGIENSKTSFLIERYKEYKIKSIESLIYTISEE
                     KKDYLDEVDRYNKLGEKEINKLINKNFLEVTYLSITTYI"
     gene            66344..66571
                     /gene="acpP"
                     /locus_tag="KRO40_000071"
     CDS             66344..66571
                     /gene="acpP"
                     /locus_tag="KRO40_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBH2090916.1"
                     /translation="MFEKIKEIIAEQLGVDNLDEITMEASLMDDLEADSLDAVEIIMA
                     LEDEFGIEIPDEEAENFKCIGDICKYIEENK"
     gene            complement(66715..67719)
                     /locus_tag="KRO40_000072"
     CDS             complement(66715..67719)
                     /locus_tag="KRO40_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBH2090917.1"
                     /translation="MIIHKFIIHVLDKNSDVPILNDFEGKVNQEVDGFFQKAIKRIAK
                     DEDLRKGVFKDYNDNLIKNCCEQIIYDESTFLKNSKEIASYLFDVMKINAALESCDLA
                     ICLYTIKDEKSVAILKLDYKKLYTHSIEFVDDKFNIQMVSNEIGIPETLRQKQGALIS
                     LSGINDEFHLRLLDKDAEKEGSESKFVTEFLNAKKIDDDKYKTKVFKNTAENWITNAL
                     SNDIKQAEDVRSILNYTLKEKHEVDINDFVDNSIKDDELKDSFKEHMEEKGLDESFSI
                     DKKWVEKKLKKRSIKTDNGFDIKGNLTDFEDPMKYTVKQNQDGTIDIIIKNVTFYEEK
                     "
     gene            complement(67733..68635)
                     /locus_tag="KRO40_000073"
     CDS             complement(67733..68635)
                     /locus_tag="KRO40_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH2090918.1"
                     /translation="MFKKENQRYNLISYTNEEEMTLKEVLLDKLNFSVRSLSKMKREK
                     SVLVNGVYKKPSLKVYSGDLIEVKIDEEKANFEPQDLNLQIIYDDFDIIMVNKPPFMV
                     VHPTKSHYDKTIANGISYYIDNQKENVKIRFVNRLDMNTSGLVIVAKNAYAHHTLSTA
                     MSENKVEKKYITVVDGIIKENEGTIDEPIYRPTEDSIKRIIDERGQSSVTHYKVIERL
                     ENATVLEVSLETGRTHQIRVHMAHIGHGIIGDELYGYVDEELINRQALHAYKLEFEQP
                     RTKEKLKFKADIPEDMKELISKLR"
     gene            complement(68830..70005)
                     /locus_tag="KRO40_000074"
     CDS             complement(68830..70005)
                     /locus_tag="KRO40_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBH2090919.1"
                     /translation="MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANIT
                     PDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLI
                     ALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
                     AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEY
                     IKPGTTMEKLAKLRPAFKKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIV
                     SYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDM
                     NKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR"
     gene            complement(70092..70937)
                     /locus_tag="KRO40_000075"
     CDS             complement(70092..70937)
                     /locus_tag="KRO40_000075"
                     /EC_number="1.1.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="HBH2090920.1"
                     /translation="MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLD
                     KNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLD
                     ELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
                     FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLG
                     ANHPMGPLALGDLIGLDVVLAIMNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGF
                     YDYNK"
     gene            complement(71035..71832)
                     /locus_tag="KRO40_000076"
     CDS             complement(71035..71832)
                     /locus_tag="KRO40_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBH2090921.1"
                     /translation="MSTSDVKVYENVAVEVDGNICTVKMNRPKALNAINSKTLEELYE
                     VFVDINNDETIDVVILTGEGKAFVAGADIAYMKDLDAVAAKDFSILGAKAFGEIENSK
                     KVVIAAVNGFALGGGCELAMACDIRIASAKAKFGQPEVTLGITPGYGGTQRLTRLVGM
                     AKAKELIFTGQVIKADEAEKIGLVNRVVEPDILIEEVEKLAKIIAKNAQLAVRYSKEA
                     IQLGAQTDINTGIDIESNLFGLCFSTKDQKEGMSAFVEKREANFIKG"
     gene            complement(71851..72861)
                     /locus_tag="KRO40_000077"
     CDS             complement(71851..72861)
                     /locus_tag="KRO40_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH2090922.1"
                     /translation="MGNVLVVIEQRENVIQTVSLELLGKATEIAKDYDTKVSALLLGS
                     KVEGLIDTLAHYGADEVIVVDDEALAVYTTEPYTKAAYEAIKAADPIVVLFGATSIGR
                     DLAPRVSARIHTGLTADCTGLAVAEDTKLLLMTRPAFGGNIMATIVCKDFRPQMSTVR
                     PGVMKKNEPDETKEAVINRFKVEFNDADKLVQVVQVIKEAKKQVKIEDAKILVSAGRG
                     MGGKENLDILYELAEIIGGEVSGSRATIDAGWLDKARQVGQTGKTVRPDLYIACGISG
                     AIQHIAGMEDAEFIVAINKNPEAPIFKYADVGIVGDVHKVLPELISQLSVAKEKGEVL
                     AN"
     gene            complement(72880..73662)
                     /locus_tag="KRO40_000078"
     CDS             complement(72880..73662)
                     /locus_tag="KRO40_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009524639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH2090923.1"
                     /translation="MNIVVCIKQVPDTTEVKLDPNTGTLIRDGVPSIINPDDKAGLEE
                     AIKLKEEMGAHVTVITMGPPQADMALKEALAMGADRGILLTDRAFAGADTWATSSALA
                     GALKNIDFDIIIAGRQAIDGDTAQVGPQIAEHLNLPSITYAEEIKTEGEYVLVKRQFE
                     DCCHDLKVKMPCLITTLKDMNTPRYMKVGRIYDAFENDVVETWTVKDIEVDPSNLGLK
                     GSPTSVFKSFTKSVKPAGTIYNEDAKTSAGIIIDKLKEKYII"
     gene            complement(73721..74857)
                     /locus_tag="KRO40_000079"
     CDS             complement(73721..74857)
                     /locus_tag="KRO40_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="HBH2090924.1"
                     /translation="MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKM
                     AKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGN
                     EEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
                     AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRI
                     PKENLLGKEGQGFKIAMSTLDGGRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSK
                     FQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAV
                     QLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK"
     gene            complement(75566..76033)
                     /locus_tag="KRO40_000080"
     CDS             complement(75566..76033)
                     /locus_tag="KRO40_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaK/EbsC family protein"
                     /protein_id="HBH2090925.1"
                     /translation="MSISNVREYFKQFGKEDSILEFEQSSATVELAAEAAGVIPARIA
                     KTLSFKIGDDAILIVTAGDAKIDNKKYKAEFNCKAKMLTPEEVLEFTGHAIGGVCPFG
                     LKNSIKVYLDDSMKRFDTVFPACGSSNSAIELTCEEMEKFSKCEKWVDVCKNW"
     gene            complement(76112..76654)
                     /locus_tag="KRO40_000081"
     CDS             complement(76112..76654)
                     /locus_tag="KRO40_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090926.1"
                     /translation="MKKFIKVSFFILGIFTLFIAINKLVYRDMVSVKDYEINHLEEIV
                     FDFDSRRSRDVGTIVRFKISNNSKYSYKLNSAKMKFENCVENKKGMNKCSAYVNVDLF
                     NEKNSITERTLKYGIKPNNQGYVDFVIPKGLNFDYRYFNESGMSVEYKGEYIVNIPMA
                     KGLYLVVGKNNDTWNANIME"
     gene            complement(76706..77392)
                     /locus_tag="KRO40_000082"
     CDS             complement(76706..77392)
                     /locus_tag="KRO40_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH2090927.1"
                     /translation="MFNLIRKDLIIGISSDGIRNLKYILLFFVFYFFLNSISYYTVSI
                     VVSYLIFINTFECDYENDSRIFIRSMPVSIEDIVYSKYLLGVGLIISVTIIVSLLSKL
                     TSLVFFRNMVLNDVFFSVNIFLAILTILLPLIFKFGYGKMKVCGFIVSILIYFVYGSL
                     LKMISMIVYQVKHFNYSKVGGVYLSNYVTDIANTKYINLYSMTFLTIIIFIISMYFSI
                     KISKKNKFNY"
     gene            complement(77392..78252)
                     /locus_tag="KRO40_000083"
     CDS             complement(77392..78252)
                     /locus_tag="KRO40_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2090928.1"
                     /translation="MFSIRNITKKLGKFKLNNINLELKEGDIVGIIGPNGSGKTTLIK
                     IIMGIIDADEGEIELCNETIENSPISFKNNIGFVYDSLQFYPHLKVKEFRKIVSLFYK
                     NFDRERFDEYLNKFDIEENMHIENLSKGQSEKLMLSSALSHNAKLLILDEPTAGIDPI
                     VRTEIMQYLQDFVKNGSSSVIISTHNTDNLIKIADYLVFINRGNQIFTVKKELIEQEY
                     KIIRANKAELEAIKESIVGVKEYKYYNEALVKVGDSLKVKSLLIEIDKHKVKNPTIEE
                     LMYYYVNEVR"
     gene            78387..79187
                     /locus_tag="KRO40_000084"
     CDS             78387..79187
                     /locus_tag="KRO40_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+)/NADH kinase"
                     /protein_id="HBH2090929.1"
                     /translation="MKRIITINTNQLNKSLETKELLTRKLINAGFEVYSDIYPDTELI
                     ISIGGDGSFLRTVRDFDFPEIPIMGINTGHLGFFPDILPDKIDSFIEAYTKKDYIIQE
                     MSLLNAEVYTTTSGSNMLAVNEVVIRGDKSRTIHLNLSLDNKHIQNFSGDGMIISTST
                     GSTAYNYSAGGSIVDINLELMQITPLHPINTNAYRCFTSSIICSNESVIKIAPEYRFE
                     DSVLIVVDGVEHRFRQIENIKVSISDAKIKLLRMSNYEFWHRVSEKFL"
     gene            79212..79781
                     /gene="yfcE"
                     /locus_tag="KRO40_000085"
     CDS             79212..79781
                     /gene="yfcE"
                     /locus_tag="KRO40_000085"
                     /EC_number="3.1.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphodiesterase"
                     /protein_id="HBH2090930.1"
                     /translation="MKIGIMSDTHGSLLYFEKALNVLSDCDVLLHGGDVLYHGPRNDI
                     PEGYNPKKFIETLNKLENIVIVKGNCDADVDQMVIEHPIQSPYVMSQFGEIRIILNHG
                     YIESEEEIIDKAKKMGGDILVLGHTHVKKLYMDDNLIVINPGSTSIPKDGSHSVAIID
                     IIKTDDEDELELDINLIDINTGNIININD"
     gene            complement(80117..81169)
                     /locus_tag="KRO40_000086"
     CDS             complement(80117..81169)
                     /locus_tag="KRO40_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp18"
                     /protein_id="HBH2090931.1"
                     /translation="MKIKSKKIIAFALSLGIMLPSCVYADTISKNQNAQVDMNNYLQG
                     RKSPKEEKLIGEDRFDTAIKISQSGWNNGSERVFLVNSNSLPDALASTPLASKLDAPI
                     LLTNKNSIPYNVTEEIKRLNPAEVILIGSEGAISSSVKESLEDMEVLVSRIGGADREE
                     TSLLLTRQLDDTGDLGVSKVAVVNGYNGLADATSISSPAASDNTAIIYTGKDSIRSEA
                     KNFITQNSTKTYIVGGEYSISKKLEGQLVNSERLAGTDRKDTNAKVLEKFYGKSSKVN
                     NMYFAKDGSGREADLVDGLAAGVLASKTKSPVVLASGSLSSAQKSFIKKVKADKFVQV
                     GGGKNSKPYAEALALQ"
     gene            complement(81395..82621)
                     /gene="pepT"
                     /locus_tag="KRO40_000087"
     CDS             complement(81395..82621)
                     /gene="pepT"
                     /locus_tag="KRO40_000087"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HBH2090932.1"
                     /translation="MKQKVVERFLKYVSFDTTSNSQCENCPSSEGQRVLAKYIVEELK
                     TMGVDDVSLDENSYIMATLKGNTDGVDTIGFISHLDTIEDVSGKDIKPRIIENYDGKD
                     IVLNEALNVITYVKDSPELEEFKGDDLIVTDGTTLLGSDDKAGIAEIVTAIEYLINHP
                     EIKHGDIKIGFTPDEEIGRGADLFDVEKFGAKYAYTLDGGIVGELECENFNAANATIT
                     IHGRNVHPGSAKNKMVNAIHIAAEISEMFPADERPETTEGYEGFWHLNSIGGNVENVS
                     MAYIIRDHCKEKFENRKSIMIENIEKINKKYDNRVELDLKDSYYNMKEKIEPVMFIVD
                     IAKEAMEELGIKPRLVPVRGGTDGARLSFNGLPCPNIFTGGLNFHGKNECIPVSSMEK
                     ATKLIVRIAEKYAERV"
     gene            complement(82712..83764)
                     /gene="ytvI"
                     /locus_tag="KRO40_000088"
     CDS             complement(82712..83764)
                     /gene="ytvI"
                     /locus_tag="KRO40_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBH2090933.1"
                     /translation="MSILENNFLYKLKNNTIFFCIYTLLFIFIYKAFPYIAPFFLGAI
                     IALMINPISQKLENKFRINKGISTLVLSFLAVAIVSTVTTIIVINSMKELMGFLNNIS
                     ANPEDISNTIMYFLNKINDFMKSFQEIANFDVEQLVNKFSGEVMQITKNLLTSILGLA
                     TSIPYIIIFIITLFIATYFIAKDLDKIENSFYNMFTVDVRKKVKNVKKEAGLSLVGYI
                     RAYTILMAITFFAIWGSFALFGLKYGLIVGFVGALMDLIPFLGIITIYLPVIVYYFLI
                     KNYFIAISMTVIFFVLSLIREILEPKLVSVNVGLNPLATLAAIFIGIQVKGIIGVIFC
                     LGLVCMHDILKKVDIF"
     gene            complement(83913..85166)
                     /locus_tag="KRO40_000089"
     CDS             complement(83913..85166)
                     /locus_tag="KRO40_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HBH2090934.1"
                     /translation="MLESPNNLIQIIFLIVLLIGSAFFSASETALMSLSKIRIRYMQD
                     EGVKGAKLVSSLIENPNKLLSSILVGNNVVNIAATSISTSLFIGLMGEKGVALATAVM
                     TVLVLIFGEITPKTIAANNSEKVSLLVSKPIKAIIFILRPIVWIFNIITNIIFKLFGI
                     TNKGAKSFITEEELKTMVNVSHEEGVLEMEEREIINNVFEFGDMQAKNAMVQRIDMVA
                     IDMEDSYDEIIQVFKTEKLSRMPVYEETIDDIVGILNIKDIIFLSDEEIESFDIKNYM
                     REPFFTYEFKKITQLLEEMKLEKSQMAIVVDEYGGTSGLLTIEDLVEVIVGDIEDEYD
                     EEEDEIQVIKEDEYIVDGSTKIGDVNELIGVNLESEEFDSIGGFIIGHLSRLPEENEV
                     IEVDNIRFCIESIEKNRIKKIRIYT"
     gene            complement(85297..88824)
                     /locus_tag="KRO40_000090"
     CDS             complement(85297..88824)
                     /locus_tag="KRO40_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2090935.1"
                     /translation="MRPIRLELTGLNSYIDKQVIDFEKLIERGLFGIFGTTGSGKSTI
                     LDAITIAMYGNISRNTKEYINSVCDKAIISYEFEIGSKNTRRRYIVDRTIARSKTGTK
                     TSNARLIEVLNDNTQNVLADKVVEVNEKVAQVVGLTANDFTRSVVLPQDKFNEFLRLS
                     RADRRDMLERIFNLEKYGRSLGEKVKKRKNIQLQNLKDLKSKLSQYDGITEEVYNKIN
                     QELIELKNLEKDKNNALDLAQKSYEESKTVYEEQLKLEKNELRKNELDLKNSEIKEKI
                     ALVENDSNAKKVDPYISSVQNLEKKLDEDSFAVSNLEKKLAILNQELEVTKNRYEKIN
                     KIKNEEVPKLSEEKIRLQQAIKLEEELVLLDRELKELKESGINLNKTKVELEKVKQVS
                     ESRKDAVTKSIKEVEGKIDKVNISAELKQKIFLAYEYEKDYNNVLEEKNQKLNKLEEI
                     LKETENINLKVRYIDKDKNDVNRNLENLSLHLDVLLKKCPGKSADLLLKSEYVTELRN
                     KANNTKENEIKKSSIQDELKIILESKFNTEREVNLLNEKLENNRKNRDDLEKELEELK
                     YLNLASELRRELKENMPCPVCGSKHHENHDITKYDENISFVKEKLEKLEKEKISIRNN
                     IEELNAKVSGYLSIEKMKTKELEDVKGKLGGIPSSQLLKKLDEEQRKLALLKSNIQEW
                     EKEKESTENKVTLAKEEKNKIEKEELKIRESLNNYKKLTRDLNIEIEGLENKCKKIKQ
                     EYLGLKTITKVSNLLSKVKEIRENEKELELLSTGHSNLLKNRDSLDIKIRENESKLHE
                     IEIELIKARELYVEKKLSRDNKYKEVISITKGDLAKNLLHNVEENICKILEQEESSKK
                     KLEEQRLEYEKNIAEKHNIDGRLKTAKEQYKDQKSTLNKLLAENKFESIYAVKRALLD
                     TDAVKKLIEEILEHEEEQKLLSFKIKSSKEKLNGRSIKKEYFEQLKDEIYNLKVEIGN
                     ISKDIGANQNQLITLKDSLDKINDFNKQLKVVEHNVDLLEELDKCVQGNKFVEYVSTN
                     QLKYIALEASKRLDGITKGRYALEIDSTLNFVMRDNFNGGERRSIDTLSGGETFLTSL
                     SLALALSSQIQLKGSAPLEFFFLDEGFGSLDSELLEIVIESLERLHSNNLSVGIISHV
                     EELKNRVPVKLLVSSSEAGIGSKVKIEYS"
     gene            complement(88811..90022)
                     /locus_tag="KRO40_000091"
     CDS             complement(88811..90022)
                     /locus_tag="KRO40_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease SbcCD subunit D"
                     /protein_id="HBH2090936.1"
                     /translation="MRFIHTSDWHLGKSLEGHSRIEEQAKFCEEFIKIVESNEIDMVI
                     IAGDVYDTSNPPAQAEKLFYQTVSRLANNGQRCVLIISGNHDNPERLSAITPLAHEQG
                     ILIYGYPLSATIEAKYKGFEITYATQGCTKLNINGENIVVATLPYPSEKRLNEVFSSE
                     DEFEKQKNYSEKVGDIFRSLEENFRSDTINIAVSHIFVIGGESTESERPIQLGGSFLV
                     ERKDLPEKAQYTALGHLHKQQKASERLNAYYSGSPLQYSKDERAYTKGAYIVDIKAGE
                     KPIIEDVYFNNYKPIEVFKCNGIEEALDICEQNQDREIWSYFEINTDEIISQNEIKKM
                     KELLKDIIEIKPIITSCYEQESVDIKEKSMAELFREFYSFSKGVEPKGELMDLFLDII
                     SEEGESADETN"
     gene            complement(90068..93895)
                     /gene="addA"
                     /locus_tag="KRO40_000092"
     CDS             complement(90068..93895)
                     /gene="addA"
                     /locus_tag="KRO40_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HBH2090937.1"
                     /translation="MSSPKWTKEQLEVIESRECNLLVAAAAGSGKTAVLVERIIQMIT
                     SRENPIDIDKLLVVTFTNAAASEMRERIGDAIGKALDENPENKHLQNQLVLLNKSSIT
                     TIHSFCLDVIKSNFHRINLDPNFRIGDQTECAILKQEAIEEVFEDLYEERDEGFLNLV
                     ESYAERGGDKEVQDIILGIYSFAMASPEPKKWLIDSAERFNIDENFDFSQSIWARAIL
                     DTVKIEINGLCLNMERALKEVESIEELETFAEKLSVEYKKIADISQACNKSWDEAYKK
                     MASMSFENYVKGVKRISKDAPSYIKESKEKAKTIRDKTKKSLESIVSATFNKDNDSIR
                     EEIKYLYNIVKPISSVVLRFEEEYSNKKREKGIIDFNDIEHFALNILTDVDEKGNIVP
                     SDIAVGYRNKFYEIFIDEYQDSNLVQEVLLKAVANTETPNRFMVGDVKQSIYRFRQAK
                     PELFLQKYNNYNDKKGSSHRKIMLYKNFRSREEVVDAVNYIFENIMNENIGEIEYTEK
                     ERLNLGANFNVDTDEKSIIGGATEIHLIQKDNKLDDDIINDKDDRINNKENEIEEEEN
                     LDNIQLEARMVGNIIKDLMKVNEDGKIQKVYDKGIDGYRPVEFRDIVILLRATSAWAP
                     VFADELMNMDIPTYADVGVGYFDTIEIKTILSLLQIIDNPMQDIPLISVLKSPIFGFT
                     PEDLIDIRVQSKDKIFYEVLKSTAEYDGFTDSQNENESEFIPSEECINKSKDFLIKLK
                     EFKEKSMYMSTDEFIWYLYTRTGYYAYVGALPGGSQRQANLKVLFERAKQFEETSLKG
                     IFNFVNFIEKLKKSSSDMGSAKTLGENANVVRIMSIHKSKGLEFPVVICSAMGKNFNT
                     QDFKKSILYHHNLGYGPQFVDYERRISFPSIAKEALKSKINIENLSEEMRVLYVAFTR
                     AKEKLIITGSTRNIQDSIKRWSNGIESLDTISQYEILKGKNFLDWIMPCVLRHRDLSN
                     LLEEVGLDAVFNVEHNSKWYGKLWNKNDILVEKKSDEEKESIEEILEKIDVDNPDSDY
                     YSEIEEKLNYIYPYEFSTRKPATISVTEIKKIQNNYEEELINTIFEQKVILKKPLFIQ
                     NEEEREKISGTERGTIVHLVMEVLDLKNVSSVNDIKSQIRGFVSKGIITEKQASIVNP
                     YKIYKFFASNIGKRMLNAEIINREKSIYAQVNMKDIYIYEKLINNDDKKLYDNESVML
                     RGIVDAYFEEDNQIVLVDYKTDFVNEENINQIIEKYKKQLDLYADIIETLTGKSVKEK
                     CIYLFGVDEAVCY"
     gene            complement(93895..97362)
                     /gene="addB"
                     /locus_tag="KRO40_000093"
     CDS             complement(93895..97362)
                     /gene="addB"
                     /locus_tag="KRO40_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddB"
                     /protein_id="HBH2090938.1"
                     /translation="MGLRFVLGRSGSGKSTYILDEIKKEAQKNETTSIILLVPEQYTF
                     EAENRVSKLFLGKEKDKYLRVRVLSFKTLSNIVFSQVGGLTDVNINSSGKAMMVYRAI
                     EDVSEELNVFSKSKSQSGFVSSITDMISEMKQYNISPEMLENISGELDNETLSLKLKD
                     ISKIYNSFEGKLHENYVDAQDMLTSLASKIELSSYLDGACVYIDEFTGFTPNQYNVIK
                     SILNKSKSVNISLTVDDINYIGYSKSDMFSRTKFTYSKLTQLCNEEGIKILPQVNLNT
                     GVIKRFEKVKELQHLERFYNAYPYKIYSNPTENIKIKEFNNLYSEVEEIAREIVHLVR
                     DKNVRYRDITIATRDLNRYDFLVHSIFNEYNIPNFIDKKREAKSNPIVILIISALEMK
                     NRRYGYETMFRYLKSGLIGIDNDDINLLENYVLANGIKGKKWFDEKWDYRITQSLSGQ
                     ESEFELELKEKINEIKNRVLEPIVILQEKLRGKNRVKEICRYIYEFLLDINMPETIES
                     LIVNFKDKGELDVANQYSQVWDIVVDILDQMVELMGDEIISLEKFIKLITLGFDEYEL
                     GLVPPSIDQVLVSSVDRMKNPDTKYLYLVGTTDGVFPLITKDSGILSDNDRESLGNKG
                     IEVDIDSKTRSFEEQFLVYKALTSTSKNLTITYPISDHEGKTLRPSIIISRLKKIFPN
                     IENKSYLVEENKSTDKDILKKITVKSPTFNELINIIKNYDSDGYNTEEINSIWLDIYR
                     YYLKDEVYSSITKKVIKGLSYTNQVHKIEEKKIRSLYKSNSLSISRLEKYAECPFAYF
                     IQYGLKAKKRKEYSFTPPDLGTFIHNILDRFSKELLQDNLTWRDIDEKYIELKIGIIV
                     DEIILKIPGYILNSSERYKYLAYRLKNMLTTAITIISQQIKQGSFEPIDYEVKFGNNG
                     KYPPIKMVLENGQEVSLIGQIDRVDEFEEGENKYIRIIDYKSGNKSISLTEIYYGLQL
                     QLLVYLDAILESAKDEDININPAAILYCRINNPIAKFNEDKDDEEIQEAILKELRMKG
                     LVVKDSHIVKEMDKSLIDGERKNSLVIPVGLTKDGNVGKSTSAISYEDFKLLRKYVRH
                     AIKDLCEEMLSGEIRIAPYKHKDGTSCDFCDYSAICQFDSTIKDNKYKNLNNKSNEEI
                     IKMMKGDVN"
     gene            complement(97352..98182)
                     /locus_tag="KRO40_000094"
     CDS             complement(97352..98182)
                     /locus_tag="KRO40_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="HBH2090939.1"
                     /translation="MNDKLKYFSYSQNSINTYKSCPLKFKYKYIDRINWKNDDVGSRE
                     YYETLKTGRDFHLICERYFSNIPLGIYFNEDDKNSKKFLKWMENIKKVVPIEKGKTYL
                     PEYEVRMTLNGDIIQAKYDLVVIGNNNIEIWDWKTESKKIDYKHVENRIQTIVYMFLA
                     KEVIPKVLKMDINVKDINMRYYQPEFDDLPITILYDEEKHEANRNKIQNYISMIKNTN
                     YEEHTYEDNLYNDIEKVYNKEERMCYRNKKHCKYCEFNKLCNGKEIDYSILEAEIYGT
                     "
     gene            complement(98291..100510)
                     /locus_tag="KRO40_000095"
     CDS             complement(98291..100510)
                     /locus_tag="KRO40_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBH2090940.1"
                     /translation="MININYREDQIPIINYDNGTMAVPAVPGAGKTFIITNLVAKLLL
                     EQKHKGGKILILTYMNSAVNNFKGRIRKILEENKIDDTNSYEVMTIHSLAVKIIKEKP
                     EVVMLSEDFNIADDLQKSIILNECISRFRFEGGERAFRWFLKEQKDERWKEITLEAWE
                     RGFFEFAGNAISELKYKGISPDKLEEILSRGHKGMLKIILPIYKLYDRKLKQNGLLDY
                     DDILILAEKTLSLDEGLRKKFQTRYKYIFEDECQDSNEIQGNIIKIISSENKNLVRVG
                     DINQSITGTFSSSDPKFFKEFINSADFCYRMDMSNRSSKDILDLANTLVKYVTKEFRQ
                     KECRHALEDMQIKTVPNGMGYKENPNPEHYNINVKWYESWKIEIEQTARYVKGIKNKY
                     PDKSIGILVPFNEQVTQVAKELRENNLTFEELGPNSLNKRKVINNIAYIIDFMLHCDD
                     VEKLIVVLNKVFIDTDNEEEIKYFLEELKNYSTEEIIYNFEFSKLDNDLIEFKEESDI
                     YLSFKRGIDIIKQILEYPIIRLDLLVLFIGKKLNLEKEDKAVLDYISFYIKYLVSENI
                     NMDLEDVYNLLFDVKNRVFNHIIDVVYEINGYEPEPGSITLCNYHKSKGMEWDCVFLL
                     GLVEYNFPDNINQKFQSDKWYLKEKYKNPMAIIKSEVEAILKGSISTDYAHKTKIDSI
                     NEKIRLLYVGITRAKEMLVLSGSAYRDESDIGNKRKEQKPCIYLSRLNQHIIEKRSN"
     gene            complement(100503..102416)
                     /locus_tag="KRO40_000096"
     CDS             complement(100503..102416)
                     /locus_tag="KRO40_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090941.1"
                     /translation="MEYLFEKSSLKEYGNEALDKYRELLDKTGNNSRCILLLVPNNNT
                     KIRYERSLRLNYSEELKITTYISFVKKELVKYWPLIIEKCDEISTKVVSPTFISNSLS
                     EYLIVQKVKEKRIQEGYFEDITGTNKSIANSIMTNINKSAFNLIDFDFIGEKIYSSKK
                     NKDSIYRFSYTQMDEIISYYINSLLSNSILDNALSIYLYNQYLLNDDFYLKNLFTEVR
                     YIIVDSLESSSNAEVDFITEALDNTLQSYIYFDYSRDYSVFNNVDIDYINEKIISKIK
                     PKEENIKKKEIRIEDLYLLPANIELNQSSQLYNEMLDLISEKVISLIEEDVSPRDIAI
                     ISPINNSILEHQIRDSLIEKNIDVFSTKKDKKAVDYPYGNALVVATCIFYGYLDFIKD
                     DEYLSFLETLLEINRIKAFKIFNETRHLSIDNIDEHSQYREILQYIEEKKKSDIKIHE
                     FLTQFYIDKMLNLKEGKKNVGLCKKIIAESESFSESLSLLGMKKEKIFIEALKSTIND
                     YYSVVDIEELKSKDKIVITTPYSYISSNIDRSIQIWVDIGSNAWNMKIEKDISNLIVL
                     RKSFEEKKIYTNEMEEYYKKYYLYNTVYNLLLNAKKIYAFKSEYAINGYIQESILYSI
                     LLKISHKGDKNYD"
     gene            complement(102658..>103377)
                     /locus_tag="KRO40_000097"
     CDS             complement(102658..>103377)
                     /locus_tag="KRO40_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2090942.1"
                     /translation="YVSAYHKDNLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNTTP
                     TEPGNSGGKTVMIDPGHGGSAPGNSSGGMIEKDYNLNTSLATTEYLRSKGFNVIMTRD
                     TDKTLSLGNRTALSNSLKPDLFTSIHYNGSTNKQGHGVEVFYKLKDKNGGITKTVATN
                     ILNRILEKFKLTNRGIKTRVLPSDSTKDYLYVLRSNDMPAVLVECAFLDNENDMSLIN
                     SSAKVKEMGTQIGKGIEDSLK"
BASE COUNT        32390 a        18819 c        10670 g        41498 t
ORIGIN      
        1 ttaaattcta ctactctatc tataatctat ttcctaatta tttaatctca aatttagctc
       61 ttcatcattt aaatctttca taagatttct acaggtacta gatttattcc aacagaaaga
      121 ctagggcatt aaacacttat atatctgttt ctttagactg taatattaat attttttaaa
      181 tacgttgact tttgcttttt ctaacttctc tccatgatag ttctcctcta tcaagagctt
      241 ttataaatat ttctgctgaa gctagatttg tagctattgg aacatgataa acatcacaaa
      301 gtcttattaa cgcttgtata tctgtttcat gagcctgaga tgtcaatggg tctcttaaaa
      361 aaataactaa atctatttct tgtgttacta ttaaagaacc tatttgttgg tctccaccta
      421 aaggaccaga tgctaatcta tttatattta attcagtttc atccattatt ctttttcctg
      481 tagttccagt tgcatatagt ccatactttt ttaaaattga ttcataacct atacaaaatc
      541 cgaccatagt gtttttcatt tggtcatgtg ctactaatgc tatattcata tatctaatct
      601 cctcaattta tgtttagatg tatttaaatt tagaaattta ttttctttct tctcatacac
      661 acatttagta ctaatcctaa gtttgctaaa gatgtcaata acgaacttcc tccataactt
      721 acaaaaggta atgttactcc agttactggt attaacgcaa ccgtcatacc tatattttgg
      781 attatctggt aaccaaacat tcccataaca ccaaccacta tgagggttcc ataaaaatct
      841 tttgcatctc ttgcaattgc taaaagcctt aataggaata tcataaataa gattatcaac
      901 actgccattc ctattacacc aagttcttca cctacaacag caaatataaa atcactatct
      961 tgtacaggta aaaaatcttc ttgattttga cttccattgt aaagtccttt accagttacg
     1021 cctccagaac caattgcaat cagagattgc ataacttgat agtttccttt tagagttaca
     1081 tcttctggat ttagaaaagc ttctattctt accttttgat ggtctgccat cattaaatac
     1141 atcagtggca ttgacactaa tagtatgatt attcctcttt ttatcaactt tgagctaaga
     1201 cctgctgtga acagcattgc aaatatcata caacaaaata caattcctgt tcccaagtct
     1261 ggttgtgcaa tcaataatcc gataaatgga agagaataaa ctacaacagg cataacttcc
     1321 tttaacgtat ttaatttatc ctttttggat tcaagtatct ttgcataact tagtacaaat
     1381 gttaatttga ctatttcaga tgtctgcaag tcaagtggtc ctaagttaat ccacgaccta
     1441 gctccacctt ttactgtccc aattccaggt aataaaacta tggctaacaa aataagactt
     1501 attatataaa gcgctttata atacctgcct agaaggttat agtcaaaaaa taatatgact
     1561 ataatcattc ctatcccaag tacaaaagct aatccttgtt taatcaattg attatatgaa
     1621 cctgttgaat tagcatgtgt tgcactacta agtataacaa gcccaaaaat aaagatagct
     1681 aatactgtaa ctataagttt ccagtctaac tgttttatca acttaattgt cgacttataa
     1741 ttaatattga tttttttcaa agaatcaccg tctttctatc tttaaacata taattaaata
     1801 aaaggggcat ataccaataa ggatatcccc cttttaagca ctaattacat acatctatct
     1861 tttatattct ttagtggtat attagcaact aatgcagata caggtttgtc atcatgctca
     1921 cctctgcatt tagacatttt tatttcaaga ccatcatctt ctatttctgc ataattagct
     1981 attactttta aaatgtctgt ttttatcatc tctaaaagtt gtggtgaaca atctactcta
     2041 tcatgaacta aaactagctt taacctctct ttagcaacag atttactagt tttagcctcg
     2101 ttagaaaaaa ctctaaataa atctaacaca gatgtatcct cctttgctac ttagccatgc
     2161 taaacatttt tttaagtcta ccaaagaatc catcttcaac ttcaagatca agtagaggaa
     2221 cttcttcatt tagtatcctt tttgcgatat ttttgtatgc ttgaccagca agtgacttag
     2281 aatcaagtat agctggctct cctttatttg ttgatataat tatgctttca tcatcaggaa
     2341 caagacctaa caaatctatt gctaatattt ctattatatc ttgtttatcc atcatgtctc
     2401 cacgcttaac catatcattt ctaattctat ttataactaa tcttatctct tttatttcat
     2461 ttgcttctaa tagacctatt attctatcag catctcttac tgctgatatt tctggattag
     2521 taactacaat agctctatct gccccagcta ctgcattttt aaagccttgc tcaatacctg
     2581 ctggacaatc tattattata tactcgaaag attcttttag tttctcacac aggtcaatca
     2641 tctgctcaac tgagacagca tttttatctc tagtttgtgc tgctggtaat aaatatagat
     2701 tatcaaatct tttgtctttt attagagctt gcttaagcct acaagttcct tcaactacat
     2761 ctactatgtc ataaactatt cgattttcaa gacccattac tacatctaag tttctaagtc
     2821 caatatctgc atccacaact actgtttttt tattttctag gcttagcgca gttcctaagt
     2881 ttgctgcggt agtagttttt ccaaccccac ctttaccaga tgttataact ataacttcgc
     2941 tcataatact accccctatt tttctttcta tttgtctaac tttgacaaat agctttcgat
     3001 tacaattctt ccattactta caaaggctat ttctgggcta atttctgatt cactttcata
     3061 attttcttca tcatctggag cttctgcaat attatctgct atttgtaata ttttaggatt
     3121 aagatttcca gcaacaacat atgcaaattc attgccttct gcacctgcat gtacaaaacc
     3181 ttctatttta cccattacaa aaacattacc tcctgctaca accttagcac cagcatttat
     3241 atctcccata acaactgtat ttgattttga aaggactttt gaaccaggtt tcatatcatt
     3301 caatataact acatcacctt caaattcaat attttcacca gatcttaggg tattgacata
     3361 ttttgttgga aaattactat tttcttcaat tttttgatct tcaacaaatt ccacatcaaa
     3421 tctagaagta attccttctt taagttctag aatctccatg tcagttaaac aatcactatt
     3481 aattttacta attttagccc cattaaaaaa gccaacatat gcttccaatt tgtttattat
     3541 tttttcctgt atttcctcaa atggagcttc tctttttata tttactatta tccctctttt
     3601 attacccttg aactctacta gttcttgact acaaatttct cttaaagaca taacaacctc
     3661 cagagtgata tatcatttat attcttcaaa tacgctttaa acccttttat tttttctata
     3721 taaagctaaa gtttatacat agattgagct atctattaat ttgtgactcg aaatttatat
     3781 tttcgtcaga agaattgtta acatcattcg tcttgttgtc atttttacta ttagttggct
     3841 ctaatcccat ataagttcca ataacttctc tagttggtaa aagtgagaat acacttgaat
     3901 caccttgagg aattacacat acaacagcta tttctgggtc atctgctgga gcaaaagcaa
     3961 cagtccacgt aaaagaacca taatcttgtt taaatctatc tatttggtca tctgttattt
     4021 ttggatttaa ttcttttata gcttttctta gatatgaaga attcacctta tcagtgtcct
     4081 ctaatctaac ttttactcca tcttctaatt cttcctctaa tttctttctt tcttcgtctt
     4141 tcaaatcttt attttctaat ttctttttta tttccttttc cttagctaat gaaagctctt
     4201 tttctttttc tgctttcatc ttatcagcta gtttaatcgc atcatttagg ttgacattat
     4261 aagatgacat atgacttttt aaatattcat actcgttatc tgtaggtatt ttcccacttt
     4321 tctcagctgt accagttttt gctgctacat ctattggaaa atcagcaaaa gcactcttcg
     4381 ctgtaccttg tcttgcaacc aatttcatac cttttgttaa ttcttttaag ttatctggat
     4441 ttttaaaagg tattttttcg actttcttct ggtcattaat tttaactgat gaataatcac
     4501 ttgaaacagc tctatcaact acagataatt ctactaaatt acctccattt gctatagcag
     4561 ctacatatct tgatatttga gctggtgtat aagcattttc accttgtcct atagctaagt
     4621 tgaatgtatc tgcagtactc cattttgcaa aattaaaata actaaatact gctaaatctg
     4681 ctacttcttc aattctatct tctttaacat ccaatttttt tagcctattc attgtttcaa
     4741 ctctaccagg agttttcttt tctgctgccc agcttacaat ctcattgatt cttttctcat
     4801 attctttagg atttttttct ctagttatat caacaaaatc atttgccatt tctctttcta
     4861 aatttgactt tagaagagct tgtgttgatt tcaatttatc ttctgtgcta ggaactttac
     4921 ctgctctttc ttctacttca tcttgaagcc ctgtattttg gtcaagccca aataattttg
     4981 catactcaag tattttattt gcattcatat ctataccaat gctttttcca tctggccatg
     5041 ttttacctgt accaattgtt gccatatata tattacaaga ctcttgtatt gctttatata
     5101 agtttgtcat accatggttt cctctaccat ggttccatac atagtcacca aaagattttt
     5161 tacctaacat tataacccca gggtcattta tagtaaagtt tggatccaga ccattttcta
     5221 acgctgccat tgaagttacc atcttaaatg aagaacctgg ctgaaattcc ccttgtgtaa
     5281 ccaagtttaa aagtggactt cctgctagta agtcatttgg attttttggt tgaagtgctt
     5341 tataatcctc tgtagaaata ccttttgcaa atttatttgg gtcataatta ggataacttg
     5401 atgaagctaa tacttctcca tttttaacat caatagctat aagagctgct gactgtgctt
     5461 ttcctgcata tgcactaatt ggtttgtccc caaatttact tttaaaagta cctcctttag
     5521 aagcaacttc gattatctgt tttaatgcat tatctgaaac ttcttgtaaa tctttatcta
     5581 gtgtaagata cacagtatct cctgatttag gttttttaga ttcaatttct ttactgattc
     5641 tacccaatgc atcaacttta accattttat aaccatcagt tcctcttaat ctactttcat
     5701 tactcttttc tactcctgca agacctacca tatctccagt ttcataacct ttttgaaggt
     5761 atgattctat ttgagtggat ggcatttttc ctacatatcc taacatatga gaagctaatg
     5821 acccattagg ataatatctt actggttcta ctgctattga aacaccaaca aggtccatag
     5881 cactttcttc aatttgagca atcgtagttt ctcccacatc cttagcaata gttactggat
     5941 tatattgaga atatcctttt gattttatca aatcccttac gaccattatt tttcttgcat
     6001 cttcatcact caaactttta tcaatttcta atgcatcact atttcttact ttttcaaacg
     6061 cttctttggc actcagttta gtttctttta tcttataact agccaaccaa tctctcttat
     6121 ctctttctgc tgtgaacatc catttactaa ctaaaatagg tggataatat ccattttcat
     6181 ttagttttgc ctgtaatctt gtcgcatcca atcttttatc ttcttgagat aatattccag
     6241 ctgatataag tttgtccacc aagtaataaa aactttcctt agcattataa tcatttggaa
     6301 taccattttc tgatttatat tccctaatat ctctgtcata tgtataatag tactttccat
     6361 tttctacata tataggaaac tcatctacat attcttcacc atttctctcc agcaaattta
     6421 taagttttaa tgatatttca tttgctcttg aatgcttatt tgcatctttc ttattaatat
     6481 cgttacctga aacttgaaca gtaaataagt ttttatttcc tgccaacagt cttccatatc
     6541 tatcttttat ttctcctctt ggagcttcta ttgccaactt tttatatgtt ttattctcag
     6601 ctaactcatt gtaatattca tatttaaatg tagtcatata gattattttt actaaaatag
     6661 ctaaaaatat cacgcccatg actatcttaa ttatttttag tctatcaact tgtttatttt
     6721 cttccatgaa atcaccaact aatcttcttt aagttttaaa actgctcttt tagataagcg
     6781 atatattact aaaccaatta aactattcac tattggtgct actagtagac cttttacaaa
     6841 aagtgttgat atgttgtagc tttgataaat tatactagat gtacctatat tgacaattga
     6901 atcaattaaa ctgcctataa aaattaaaac gaaagtaata atataactac ctttatatag
     6961 ctgatctctc atgtatccaa ttgcatatgc aataataaac aaaattaatg catttacacc
     7021 aaaaattcca ccaacggtta tgtctttaat aagccctatt attgctgcta taatcccacc
     7081 ttctaattca tctaaataaa gagagattat ggttacatat ataagaacta aattaaagct
     7141 tatgccaaaa atatctatat aatttgttat actattttct atagtcataa gcacaatccc
     7201 caacagacaa agtaaaactt ttttcattgt ttttatcccc tttatcctat atttcttggt
     7261 tctatgacta caacgtcatt tatattctta aaatcaacat aaggttttac aactacatat
     7321 tttaatgact tatctttatc atcaaccact ttttcaactt cgccaattgg tataccatct
     7381 gggaagaatc caagacctga tgttgttatt atatctcctt gaattacatt atatgatgag
     7441 tcaaacatat atccttgcaa atatccttta ctattataac tatctttatt atctaaagta
     7501 gtattttgag taattgtacc tttagcattg gcatcctttg ctagtttaaa gcttacagat
     7561 gccttagaat ccaatagtga aattgcctta ctataattgt tggaaacctc ataaactatg
     7621 ccaactaatc cactaccatt cataactata ctttcttttt ttacacctga attttttcct
     7681 gcacctatga caaaactctc ataccagttt ccatcatttt taccaacaac acttgctgaa
     7741 atacttgtcg ccttatactc ttcttgtaca aagttcagtg tcttttttaa ctcttctagc
     7801 gattctgttt tatctagttt ggcatttaaa gctatcatat tttttttaag tttttcattt
     7861 tcttcttcta atttttttac ctttttagaa ttatctttaa aatttgctac atctttaaaa
     7921 ccatttttga taaaagaaaa tccatcattt attcccttac ctacacttgt aatagcatct
     7981 gaagctactc ctaaatttac tggactacca ctagaaaatt taccaattga tatacccaca
     8041 attccaatta aagtgatagc aactacgccc gttgctatca ctttaacatt aatccttttt
     8101 ttctcatttt tgttcttgtc aaatctcaag gccatcacca acttctaatt cttagtattc
     8161 atcattaata ctttttcaaa gatttcttgg tcttcaacag atttacctgt tccaagtgca
     8221 acacaatcaa gaggtgtttc tgctatttgt acagacatac cagtttcctg tgtaataagc
     8281 ttatcaagac ctctaagcaa agcgcctcct cctgttagca ttattccgtt ttccattata
     8341 tctgaggcta attctggtgg agttctttct agtgtagatt ttattgcatc tactattgaa
     8401 cttacaggtt cttttaatgc ttctctaact tctgtagagc atatttctat tgttttaggt
     8461 aatcctgaga ttaaatctct acctcttatt tgcatattta tttcttcatc atctttaaat
     8521 gtagaaccta tgttaatttt tacattttca gcagttcttt cacctatcat aagattatat
     8581 tcttttttta cataagccac tatagactcg tcaaattcgt ctccacctat tcttatagat
     8641 ttagcagtaa cgattcctcc taaagatatt acagctattt ctgaagtacc tccaccaata
     8701 tcaactacca tattaccttc tggttcttca acttttaatc cagcccctat agccgctgcc
     8761 attggctctt ctataaggaa tgcatcttta gctcctgctt gtcttgcagc ctcttctata
     8821 gctctctttt ctacttctgt aactccaaaa ggaacacata tagctattct tggacttaca
     8881 acaccttttt tatcagccgc tttttgtata aaatagctaa tcattgattg agttatgtca
     8941 aaatcagcta ttactccatc tttcataggt cttatagcta ctatatttcc tggtgttctc
     9001 cctatcattt ttttggcttc ttcacctact gctaatacct ctttactatc atctcttatt
     9061 gcgacaactg atggttctct aacaacaata ccttgtcctt ttatgtaaac taatgtattt
     9121 gcagtcccta aatctattcc catatccttt gtcatcttat taaaactaaa aaaacctttt
     9181 ttttctttct ttttttcctt agccatgatt ttactccttc ctactattaa gaatcatgtt
     9241 taaaacattc tcctattatt ttatcacata taaagtcaaa ttatcatatt ttctttaaag
     9301 ctaaagtata atccatctcc aataattata tggtctatta tttctattcc aattatttct
     9361 ccacatttaa taagtcttga tgtgatattt ttatcttctc ttgatggttc tacacttcct
     9421 gaagggtgat tatgcatcac tattatctta cttgcacttc ttcttatagc ttctttaaaa
     9481 acctctcttg gatggactaa tgacgagctt aaagtcccta tagatacatc tacatcagat
     9541 attatctcat tttttgtgtt taaaagaacc gctttaaaaa cctctttttt taaatacctt
     9601 aggctatcca tataatacct ctgtatatcc caaggattcc ttattttata ctttataggt
     9661 ttaaaactag ctactctaga gcctagttct aaagctgctt taatttgggt tgattttgat
     9721 aacccaattc catctatatt acacagctcc tctattgtca tatcttctaa atgtctaata
     9781 ccctgaatat ctctatttat tatatagttg gctaattcaa tagcattttt attcttgttg
     9841 ccagttctta aaagtatagc caacaactca gcatttgata agctttttac gcctttggca
     9901 agcatctttt ctctgggtct ttcctctggt gccatttctt ttaccttaat ggttgaatta
     9961 aatgactttt tcagataaat cacactccat aaaaaagatt tatactaaaa tattttttta
    10021 ataggtcgcc taaccttgaa attggaagac caactatatt aaaataatct cctctaattt
    10081 cttcaactaa caaagctcca taaccctgta taccataggc tcctgctttg tcaaatgact
    10141 cattagtttt cagataatcc tcaatatcct gctctgataa cgttttaaat ttcacattgc
    10201 tgattacata gtcaattacc tttttatctt cgcacaagtt tattaagcta atacctgtta
    10261 tgacttgatg ctctcttcca gatagtcttt ttaacatatc tcttgcacaa gactcatctt
    10321 ttggttttcc taaaatagca ttgtctaaaa caacaactgt atcagctcca ataacaacat
    10381 cttcattatg ttcagatgct acagacatac ttttttcaaa agctaatctc ataactaaat
    10441 gttttggtgt ttcaccttcc aatataatct catcaatttc atttttaatt atatcaaatc
    10501 ttacattcgt attctctaga atttctttcc ttcttggaga ggctgatgcc aagattatat
    10561 tcatttattc acctcatttg tacgtaattt gtacctattt agtctatcac tatattgtaa
    10621 aaaattcaac agaaatgtcg aacctttttt gttacactat tgttatattt attaccatta
    10681 gaataaatat acataaaata gaggtatgga aattattcca tacctctgtt ttatgtactc
    10741 attagagata tggaaattat tccatatcct tattttgtcc atattacaaa attttaatag
    10801 ctttctttgg acatttttcc atacataaat ggcatcctac acatttatct gcatctacct
    10861 tatgtttttc ttttaattct ccctctattg catcaaactt acattgtttt ttgcacactg
    10921 tacatccaac acaaagttct tggtcaatag taactttctt tttcttagtt atgtcacctg
    10981 atattacttt tgtagggcat tttgctacac attgcataca acctacacac ttattagggt
    11041 ctatcttagc tattttgtct tcaaatatta ttgcatcaaa tttacaagct tttacacaca
    11101 ttccacagcc aatacatcca gcagtacatt tttctttaac agctttacca aactctttgc
    11161 tattacactc tacaactact tcttgacttt ctggttttgt gattattata cccttaggac
    11221 aaacttcttt acattttcca caatttacac acttttcttc atctattact gctattccat
    11281 caactataga aatagcatca aatttacaag catctttaca tgttccaaga cctaaacatc
    11341 caaatttaca catcttagca cctgagttta aaacatttgc tgctctacaa tctgatattc
    11401 cttcatactc atatttatct tttgcacttg aacaagttcc tttacaaata acttttgcta
    11461 cttgtttctc acctgcttca gcacttattc ccattatttc tccaactttt gcaccaacat
    11521 ctgctccacc tacagggcaa ccattaactg gtgcattgcc ttcaactatc gcatttgcaa
    11581 gacctccaca acctggaaat ccacaacctc cacagttggc tcctggaagt actcctagta
    11641 tagcttccac tctctcgtct acttctacag caaacttttt agatgcaaaa tctagtacta
    11701 tcccgaagat taagcccata attcctaaaa ctaatacagc tgtaagtatc accattttca
    11761 cccctctttt ttatagcttt ataagtcctg taaatcctaa gaaagctatt gacattaaac
    11821 ctgctgatat aagcgttata gggaaacctt taaatgcttc tggtatatca gctaattcta
    11881 gtctttctct tatacctgcg aatattacta ttgctaaagt aaatccagct ccggctccaa
    11941 atccgtttat tattgtttct actaaattat aacttttttg aacattaact agagctatac
    12001 caagaactgc acagtttgta gttataagag gtaaataaac tcctaatgct tgatataaag
    12061 atggactcat cttttgaatt accatttcaa cgaactgaac tatagaagct ataaccaata
    12121 taaaagctat tgtttgtaag aatccagttc cagtttttac taataaaatc tgtataaaat
    12181 aagttataat tgaagctaga gttaaaacga acgtaactgc aactcccatc cctactgctg
    12241 tatcaacctt cttagaaact cccaagaaag gacatatacc caagaattga gatgttataa
    12301 cgttattaac aagaacgata cttaaaaata aaagtattaa attcatttat tacacctcca
    12361 ctatgctttt ttacttctta atttattaaa tcctgcaaat aagaatccta atgttaagaa
    12421 tgcacctggt ggtaatataa atattaatac tggttggaaa gatgctccaa ataatgtcat
    12481 tccaaataaa ctaccatttc caagtaattc tcttactgca cctattattg taagtgcaac
    12541 agtaaatcca agaccttgac ctacaccatc aactattgaa ggcatagctc ctgttttgaa
    12601 agcaaaactt tctgcacgag ctaatattaa acagttaaca actattaatg gtatatatat
    12661 accaagagcc ttatcaagag caggaacata tgcttttaaa agcataccta ctattgtaac
    12721 aaatgtagct ataactacta taaatatagg tattcttatc ttatctggtg taatttttct
    12781 tattaaagat ataactaaat ttgcacatat taaaactgct gctgttgaaa gacccatacc
    12841 aattccattt attgctgaag ttgtaacggc tagtgttgga cacataccta taacttgaac
    12901 aaatgttggg ttctcatcta ttagcccatt tttaaatact ttagctaaat tcataattaa
    12961 ccctccttat ttattaagag cactattgaa aacatctata gcagcattta ctcctgtagt
    13021 aactgctgta gatgtaatag ttgcacctga tattgctaat atttgattat ctgctgttgt
    13081 acttcctttt gctacttcaa gaggctcagc agtttttcct ttgtattgac ccttaaatgc
    13141 atcatcctta gcttttgctc caagacctgc tgtttctgac atattaccaa tgtcaacacc
    13201 tgtaacttga ccttcagatg atatacctac cataacttca atttctccac catatccact
    13261 tggtttagct tttaaagtat atccaaccac ttcagaacca tctaaacctt catacacttc
    13321 agctataaga ccatctccaa ggcctttgta agtatcttcc ttcatttctt taaattcttt
    13381 tgcttctgga aggactgctt ttctaagttc attatttgct tgtatatttc tttgttctat
    13441 tactggagct gtaacctgat tagtagctcc aagagctaat gcagctattg cacttatagc
    13501 aagtaaagta ccacctaatc tcaccatact gttcattatt tagccacctc cccaaatact
    13561 ctatttctaa caaacttatc tataagtgga gcaagacagt tcactaatag tattgagtaa
    13621 gatacacctt ctggatatcc accatacatt cttataacag ttgttataag accagctaat
    13681 acagcgtata ttatttgacc ttttttagtc ataggcgaag ttgtataatc cgtaagcatg
    13741 aagaatccac ctaacataag tcctccagca aacagttgat atattgcgaa agttatatta
    13801 aatccaccta aaaggaatgt taatataaat acagttgcta tgtaaaatac tggtataaca
    13861 taatttatta tgcctttata cattaggtat actccaccta ataataataa tattgctgat
    13921 gtctcaccta tacatccacc aatattccct atcatcatgt cagcaagact aattccattg
    13981 ctagaaagat ctgccagtcc tgctgctcca tttttcaaaa agcttaatgg agttgctgta
    14041 gtaactgcat ctaaattttt acctatccag ttaacacctg gttgagtcca agcagtcatt
    14101 gctactggga atgatgctaa taaaaatgct cttgcagcaa gtgctggatt gacaaagtta
    14161 catccaattc caccaaatac cattttaact actaatattg caaatattcc tcctactaga
    14221 cacatccacc aaggaagtga tgctggtacg ttaaatgcta ataataatcc tgttacaaca
    14281 gctgaaaaat ctcctatagt acttttttgc ttcgtaaatt tttgatataa aaattcagta
    14341 cctactgtac caagtataca aaaaaacata gcactcaaag cattaagtct aaagaagtat
    14401 actcctgcta ctgctgctgg aaggagtgct ataataactt gtttcattat atatgaagta
    14461 tcttcattac ttctcatatg aggagaagat gatactatca acttattttc catcgttttt
    14521 cccccttaac tttctttatt tctgagcagc ttgctttctt ctctttgctc ctatttctct
    14581 ctttgctgat cttatagatt gaagtaatgg tcttcttgct ggacaaataa atgagcaaga
    14641 cccacattct atacaatcca ttgctctatg atattcagct gtgtcatagt catcttttaa
    14701 agaatatgca cttatgaaaa gtggttgtaa gaatgatgga catacatctg tacatcttcc
    14761 acatcttaaa cagttttgaa tatctggagt acgtgattct tcctcatcca aacataaaat
    14821 tcctgaagaa cctttgttag tcgctatttc agtagtatat tgagctattc ccatcatagg
    14881 tccacccatt ataaccttac caatcttctt atcttcttta aatccaccac attgttctat
    14941 tatttctgaa actaatgttc caacttttgt tattaggttc tttggctctt tgatgcaact
    15001 acctgttatt gtagtgattc tttcaaccaa aggcatacct gttttaatag acttagctat
    15061 ctgtgctgct gtggcaacgt tgtcaacaac tgcacctgct gctattggta atccaccaga
    15121 tggaacttct ttgcctgtac acgcataaat aagttgtttc tctgctcctt gtggatattt
    15181 cacttgaagg ccaacaactt cgatttcgct atagtcttta gctacatttt gaattgcttc
    15241 tatagcatct ggtttattcg tttcaattcc tataaatcct tttttgacat ctaatacctt
    15301 cattaatgct cttaaaccaa acacaacatc ttctggattt tcaaccatta atctgtggtc
    15361 tgcagttaag tatggttcac attctgcacc atttaatata actacttctg ccttgctatc
    15421 tggtggagga gatactttta catggttagg gaatgtagct ccacccatac ctactattcc
    15481 tgcctctttt atgataccta ctatatcttc tttgctcaaa tcctctaact gaccttttgg
    15541 ttgaacactc tcatgtaatt cttccttaaa gtcattttcg ataactacac attgagctga
    15601 acctcctggt acttcatgtt gttcaatagc aataacttta cctgatactg aagaatgaac
    15661 gttacatgaa acaaaacctt gttgttcacc tattttttgc ccaaacttta cttcatcacc
    15721 aacttcaaca ataggtttag ctggtgcccc tatatgttgc tgaagaggaa tgtaaactat
    15781 ctttggagct tgagcttttt caagtgcctt tgtgttagag tactcttttc tatatggagg
    15841 atgtatccct cccttaaaag ttaagagttt cattgtttta cccccttatc tataaaaaaa
    15901 cattttttct gccttctata agtatactat atatattaaa aaatcttaac aattgttaaa
    15961 aaaatatccg tatttttata atttatttta taaatcaaca cctctatatt aagtcaaatt
    16021 gaggaaaagg attgcttaat taaacaatcc ttttcatata gctttctaaa gtccaaattt
    16081 tctgtatttt attttataga atttataaac atagagtact cctgcatgga tgataaaagc
    16141 agacttttac ttacactata tttttcttca tttgctgctt ttgaagctgt atcaattttt
    16201 tcattcacat tctttacata ctctattaaa ttatctttaa ataaacgcat ttcagaataa
    16261 tcaatctttt cagcttcttt tgatatattt tgtgatattg cctttctatt tgtcaaaata
    16321 gtattatatt tttccatatc tacattattt tcagcattcg accaaaaact tgattcttct
    16381 ttaaagtttg ttattaattt atttaattct ttagatatac tctctatata agcgtagtta
    16441 cttgtatact ctaaagacaa cataggtgca tctaagtgtg ataaaaatgc atctggaaac
    16501 acctttctta cactgcttat ctgctttcta acatcatttt catcaaaaga ggaataggtc
    16561 tgtatttttt ttactccatc cttctccata actgaaaaag gtatgtcatt attaactaat
    16621 gatgtctgta tttttttcaa atcatcatta ttatctattg cagcaacttg aatagtatac
    16681 atatcccagc cttctatagt agctaatttg acttcttctg gctctttagt gttatttacc
    16741 gctttttctg gattagtttc ttgtttatca tctgaattgg tttgtgattt agattttttc
    16801 ccttttttta ttgaatttaa ttcatcagat atatctttat aagttatatc tgatgaatta
    16861 tttagaaatg gtattttagc cgatacatac tccaatatct tgctatcttt tatttttgta
    16921 taagaataat agccaattag acacaagcaa gcaatcgtta taacatattt acgtaaatca
    16981 atcttatgtc tattattatt aaatcctctg tatatcgttt ttcttctatt cattagtttg
    17041 tccctcccaa aattatatta ttaataaagt atatttttaa gagtcacaat ttatgaatat
    17101 aaataattat ttcttctaat tttttaataa gaaattgtac ttactaaaca aatcttcttg
    17161 caccaagtaa tactttagac caatatgaac tagttaaatt atccacttta accttattag
    17221 gattagtctg agtaccacta caatggataa atttactatt tcctacatat atacctacat
    17281 gattagttgt tccatcacca tcagtgtcaa aataaactaa atctcctggt gcataattcc
    17341 ccatagaaat tgcacttcca aaattagcct gttctctaga aactctagga atagaaacgc
    17401 ctacagaatg tttaaaaaca tactgtgtaa atccagaaca gtcaaattta tcaggccctg
    17461 aagctcccca ttgatatggt attccaataa gagtatatgc aaaatctacg attgttgaac
    17521 cttttgctgt agatttatct gaatttccag taaatgatgg ctttgagtta ctattaggtt
    17581 gagaattttg gttagatgat gaatttggtt tttcttttgt accttcatta gtctcagaaa
    17641 tataacttgc actcacccat ccaattgttc cactcgataa ctttacctta taccaaccat
    17701 tacttttagc ttttaattca acaacatctc caccatttaa ttttcctatt atagaatagc
    17761 ttgtcccagg accacttctt acatttaaac tcacagcaga tgttacctta ccattcttgc
    17821 cttcaattga ttcttcgcta gatggttttt tatcagaatt attagtacta tttgaattac
    17881 tagaattgtt cgttccaaca tcttctgatg ttttagaaat atattggcta ctagcccatc
    17941 cagtaactcc atttgatagt tttattttat accatccatt gctttgttct agtaacttta
    18001 ctatatctcc attatttgct ttaccaacta atgaatagtt agtacctgca ccacttctta
    18061 cattcagtct agaactcaca tttactttac catttccact aatagttgtc ccacttgaag
    18121 ttggattatt ttgacttgat gtaccttcag acgaaccact tgttgatatg tattttgcac
    18181 ttccccatcc aacaacagaa ctcgataccc ttactttata ccatccatta gacttttcta
    18241 aaatctctac agtttttccc ttgtataatt ttgctacctt atcgcaatca gaacttggtc
    18301 cacttcttat attcaaggca cttgctgtta ctgttccctt ttcaagagca cttgcattta
    18361 tggagctaac agatactgct actgccccaa ttcctaaagc tgctatagct tttttcacta
    18421 ctatcactcc ccccaacaaa tttttatagt cataaattca taacattatt atccattttt
    18481 agtccctaca atttaatgat aacttatttt cttattaatt gtaaagaaat tataaacata
    18541 tccttaaaat tagtgatttt taggaagtat ttcaatccaa taattatctg ggtccgctat
    18601 aaaataaatt cccatacttt cattttcaaa acatatgcaa tctaaatctt tatgaagttt
    18661 ttttgcctca tcaaactcct caacttctaa agccagatga aattcattgt ctcctaaatt
    18721 atatggtcta tcccaatctc taagccaagt taattctaat gtatgactag taatgccatc
    18781 tcctaaataa actaatataa aacttccatc ttctgcttcc ttgcgcttta cctctttaag
    18841 ccctaaagct tttttataaa aatctaaact tttttctaaa ttagtaacat tgaaattgtt
    18901 atgacaaaaa ttaaacttca ttttgaaatc actctccaat ttttattttt tttatattat
    18961 atcattatta taaatttatt taaatcatat taagttaaaa atttgaatga tgatgaccaa
    19021 ttaccaaatc atggtaaatt atttaaaaga atatgtcaaa aaaagaataa gctctttcaa
    19081 atgcataaaa aatttatacc caagttatac ttaatcatgc aaattggcag aacttattct
    19141 ttaaaactct aacttttaag tttttcttta ataatataat ttattacttt ttttctaata
    19201 tcttcagcat tataatcatc ttctacttct atatccaaaa gttttgctat tgacctcata
    19261 tcttctctag tctttgacct atagcttgat attaattcat cttttatttt ctctggttct
    19321 aaaagatatt cttcatctcc tcttttgaaa acaacgtatt tttgagcata tgaacttcta
    19381 ttgtagtata tatatcttga tatttttctt aaaatttgat tatatgaaag tcgcttgtta
    19441 atatcaagtt ttaagtactc tgaaaaagca aatagctctt tttttgattt aaataatgct
    19501 tctttcttta tagttcttga tattgaagtt acactttctt gatatgcaca cttttttaac
    19561 atttttaaat atactctatt aagaccaata ctttgattga atttttttat attattatta
    19621 ataatcttat ccaagttacc ttcaaagtat ttttttgctc ctttttgtga tacataactc
    19681 tcaagttctt tgtgggccat atcaagtatc atttttttta aatcctcttt atatccccta
    19741 gattccatga tactccctcc cttagctatt tatagtatat tcaaaaagct caagaaatgt
    19801 gagtcattac aaaatttttt tactttttat gtatatatta atttaaaagg ggagataata
    19861 gtaatgtaaa atcaaacata ctcaatctcc cccattttta gacctctatt actcccccaa
    19921 tagaggtctt tttttagttt atcaatttct attcaattcc ctttagttca aatcctaatt
    19981 ctgctatcac ttcttttaat ttttcaatag atacatcatc tttcatatct acagatgcac
    20041 acttattttc taaatctaca tctaaaactt caataccatc tatatcttct gttaatgcag
    20101 ttttaagatg gtttacacaa tgaccacaac tcataccttc tactaatagt ttcttcttca
    20161 tttaattacc tccttatacc ctataagggt attctatcat atagtttata ctttttaaat
    20221 agaaattaat catttaattt gattcattcg attttatatc taaattagat attccctcat
    20281 atacatcaaa atcatttgga gtaattttac cttttaatct actattactt acaatatagt
    20341 tgtttctcac agctaaactt ataaatgttg cattatcttt tatatatgtc tgtacatctt
    20401 tgtatgcttt ttttgtttca atttcagacg tagaacttgt aagtgcagac atatatccat
    20461 ttaacttatc atcagtatat ccactactcg ctataatact acttgcatct ggtataattg
    20521 atagtttcca tccaactaat gctaaatcat aatttttaga attaagagca ttttccatat
    20581 ccttatctga cagctgattt actgtactat ttattcctat agcttttaag ttttcattta
    20641 ttatgtttgc agtttttatt ctctcactat tatctctgtt tactattatc tttaagttca
    20701 tttcagaaag acttttcttt acttcctctt tttctctatt ttttttctct tcagcttctt
    20761 ttttgattct atcttcttct gcttttttag cttttgcttc ttcttctggc gtaagcttct
    20821 ttgagttctt tttagctgat tttttctgat tttttacttt attgtcattt tgatttactg
    20881 agtttacatt tgcatattct accttagcaa gacactctat cgccttatct ttattaaact
    20941 ctaaatcctt catttcacta ttatagtatt ttgattttga attaagtgga aaattaactg
    21001 gagtagcatc atccatataa ccttcactaa taattctatc tttatctata gagtgtgcaa
    21061 ttgcttttct aaaattaaca tctttgaaaa aaggattatt ataattaaat aatacacact
    21121 cataatctct tccttgatat tttgttatat taaactcttt ttcttgaaac ttacttaaat
    21181 catttaatgt aacattggtt atatcactat caagagccat aaccatagat gtccttgcat
    21241 cttcattagg caccatacct acttttatgt tcttcatggt ttttggaact tcttcatagt
    21301 aatctttgtt tacagataaa accattcctt ctctttctgt atatgattct attttatatt
    21361 tcccatttcc tatcatatta ttattcttgt catttacatc ttttgaatct aaatgatttt
    21421 gagatacaat tggaaaaatt aaactatcaa ttgaaaaagc atatctagct ttaaatttta
    21481 ttgtaaaatc tttatctgat ttaatattca cagaagctat atttttagta aattcattat
    21541 atggactatc tgcacttttt tgaattaaac caatagtata gtttacatca tttgaagtaa
    21601 cattttttcc atcatgccac tttgcatctt ttagctttat atctatactc attccatcct
    21661 gagctatatt atactcctta actaattgag gaattacatt gtagttctca tctatagtaa
    21721 ataaactatc ataaactaaa ttcattatat aaccaacaga cttatcagta ttagttatag
    21781 gatttatagt ttttggagtt accattgtta agtttatata cttagcatct atcgaacttt
    21841 gactttgtaa acttgaatca ctactacttt gttttgtttt agtattacta caaccagcta
    21901 ccataagagt tatagctaaa acgactgtta agacttttat tctcttcatt agttttttcc
    21961 tttcttgcca tatatcttat tataatgttc gtaattattt tttacttttt ctacatattt
    22021 tgaagtttgc ttaaaaggta tatcatgtag attttcgcca tctttactat attcattatt
    22081 ttctaaccat tttttcacat tacctgaacc accattatat gcagctatca ctaaatctaa
    22141 tttaccaaat tctttgtata acttacttaa ataccaacag ccaagtctta tattagtctc
    22201 tgggtcgaaa atatccacat tttttaaatt tagttcctct gctccccaat ctctagttat
    22261 gtctaatatt tgcattaatc cttttgcttc cttttttgaa acagcagaac tattaaactt
    22321 actttcggct ttaataacac tgtaaactat attttcatct aaattaaatt ctttcgaata
    22381 cttttctaca tactctgaat attttttagg atataaaaat ttatgtatta ctttgctttc
    22441 cattaatagt gccccaaata agattataaa aatagataga atcaatactt tcttactatt
    22501 cacgccaatt ctccttcatg tactcaataa atttatgtgc tttactttct aattcagtta
    22561 ttgttcccga attatctatt atataatcac catatttgga tttttcttcc tgactcatct
    22621 gtgaatttat cctactaagt gcttcctgct cactgcaatt atctctcttt tgtattctac
    22681 taatttgtac ttcttgttta caagtaacta ctaatagctt gtcaaccata tctaaaaaac
    22741 cactttctac caatattgcc gcatctaaca ctactatatt ttcgcctttt tttctcaatt
    22801 tttctatttc acttattatt ttttctctta ttcgtggatg agtcaagtta tttaattcct
    22861 taagtttttc ttcatcacta aaaactattt tcccaagagc ttttctattt agagttccat
    22921 catcattttt tatactttgc ccaaaatgga caaatacttt ttccaataac aacttatcct
    22981 caaatatctt cctggatata atatcagcat ccactatagg aatgttaaga tttctaaata
    23041 tatttgatag gctgcttttt ccacagccta ttcctcctgt aagtcctaat atcaacataa
    23101 aatcacctac tttgtctcat accaagaact acctacattt aaatctacat ctaagtgaac
    23161 atccatattt acagcatttt ccatttcttc ttttactatt ttcttaacta tatctatttc
    23221 atcatcaatt gcttcaacta tcaactcgtc gtgaacttgt agtataagtt ttgatttcaa
    23281 attgttctct tccaattttt tatgaacatt tatcatagca atttttatta tatctgctgc
    23341 acttccttgt attggtgcat tcattgcaaa tctctttcct ctatttcttt ccataaaatt
    23401 gcttgacttt atttctggta tatatcttct tctgtttaaa attgttacag catatccatc
    23461 ctcactagcc ttttctactg ttgtgtccat aaactctttt attttatggt atttagcaaa
    23521 ataactttcg atatattctt tcgcctttgg aacaggtata tttaaatcat cagctagacc
    23581 aaagtcactt ttaccatata taataccaaa gtttacagct ttagctgcac ctctcaattc
    23641 actagtaaca tcttccatag gaacattaaa aacttgtgaa gctgttttgg tatgaatatc
    23701 ttcatgatgt ttaaatgctt ctatcatatt ttcatcctga ctcatatgtg caagaactct
    23761 tagctctact tgtgagtaat cggcatcaac caacttacag ttatcatctg caataaacac
    23821 ttttcttatt tttctaccca tttccatttt tataggtata ttttgaagat ttggttctgt
    23881 agatgaaatt cttcctgtag tcgttatagt ttgattaaat gatgaatgta ttctattact
    23941 ttctggattt attatattta aaagtccttc aacgtaagta gaatttaact ttactatttg
    24001 tctatactca gttatcttat ctattattgg atgcttatct cttaattttt ctaaaacatc
    24061 tgcattagtt gaatatccag ttttagtttt tttaattatt ggaagctcta atttttcaaa
    24121 taatataaca cccaattgtt ttggtgaatt tatattgaat ggctctcctg ataattcata
    24181 aatttccttt tctaatgtag ctattatttc tttaaattca acactcaatt catccaatat
    24241 acttttgtct acttttatac cttcatactc catatgacct aagacttcta ctaaaggcat
    24301 ctctacatga taaaaaagac catccatact catatccatt agacttcttt ccatcatagg
    24361 aactgtttct ttaactgtgc atattatttg acccatatac tctgctaaat cctcaaattc
    24421 taaatcctca tagtttttag atttaacacc ctttcctaat aattcttctt ttgatttaac
    24481 cttttttgat aaatacttca tagctattgc actacaatca tatgaggtag atgaagttga
    24541 atctattaag tactcagcta ttgttatatc aaaatacata ttttctaagt ttatattata
    24601 tggttttaaa gatatataat catcttttaa attatatcca tactttttaa tttcattatt
    24661 tgaaaatata ctatctaact ttgacacttc atttgaatct acataatata ttttttctcc
    24721 atctacactt ataaaaatat atattatatt tttttcaagt atattacctt gtcctctaac
    24781 agtttttaaa ataacttgtc cttttttgtt tacttcatct ataaattttt ctatatcttt
    24841 taattttaat atttctattt tttcttctac gtgttctgtg tcatctgaat cgaccaaatc
    24901 aactaatctt gataagagac ttgtaaatcc aaagtatcta aatttatcta aaagttcatc
    24961 tttatcataa tcgccaaaaa tcatactatc taaatccact tctattggca catctcttat
    25021 aattgttgca agtcttttac tttgaatagc tatttctttg ttttcctcta ttttcttttt
    25081 tacactacct ttaagcttat ctgtattctc tattagattc tctatactag aaaactcttt
    25141 tataagcttt atacctgttt tttcacctat tccaggtact ccaggtatat tatcagactt
    25201 gtctcccata agacccttta aatcgataaa ttgtgttgga gtcatctcat atttttcaat
    25261 tacagaatta aagttgtatt cttctacttc tccaacccct tttttcgtta taagggtagt
    25321 tgtattatct gaagcaagtt gaatagcatc tttatctcca gttactatgt ataccttata
    25381 tccattttct tctgcttttt tagaaacagt acctataata tcatctgcct cataaccatc
    25441 tatttctagt ctatttattc taaatttatc taaaaggtct tttaatggct gtaattgttc
    25501 tgccaattca tctggcatac cctttcttcc agccttataa tctttatatt ctaaatgcct
    25561 aaatgtaggt gcttttctgt caaaagctac acttatatgt gttggtttat atatatctat
    25621 cattttaaat agcattgtag taaacccata tatagcattg gtctttaacc cttctttatt
    25681 attcatttct ggaagagcat aaaaagctct atttattatt gaatttccat ctattataat
    25741 taattttttt tccaaattat atcactccta aaaattatct atttttgtaa catatatatt
    25801 atataccaat atagtgttat ttaatattcc cataataata atagtatatt aaaattaaat
    25861 atgttgcaaa caatatattt ttttgctata ataatataca tgacatgccc gagtggtgga
    25921 attggtagac gcagtggact caaaatccac cggactaata ctccgtgccg gttcgagtcc
    25981 ggcctcgggc accattaaaa actcctaaag ctatttattc aatagattag gagttttttt
    26041 atttttgatt taaattttaa gttatttttt gaaattactg tgtcttttta aaatttatat
    26101 aattatataa atttatcttc tagcattaat ttaaaaacta atttactttt atataatttt
    26161 ctattttata tcataactta ttacaacctt ttatctaatt tattgtatac aacaacacta
    26221 caaataaatt gaaataaaat aagcaatcca agaacaacta aaacccactt gcttattacc
    26281 attacagaaa atacactcaa tatagaaaca ataaatataa gaattacaag aacatagcac
    26341 atgatttgat tagtaatacg tccagcttta tcacgtaaca taattcttct ttcatcattc
    26401 atctctatcc tttgattttt tatcttttct tcataatcta ctgctctttc aggtttactc
    26461 caatacatat attgaagaat catacataca cctggaccta aagcagctcc agataatccc
    26521 caaataaaag cctcaaatga aaactcagta aatgtagcca ataaaacaag taaaattcca
    26581 caaataaaat atataattcc aacatataac atattctttt tcatttttac tcctcctcat
    26641 aaataaatat ttcttcaata ctcatatcaa agtatctagc tatcttaaag gctaagatga
    26701 tagaaggatt atacctacca ttttctaatg aacctatagt ttgtcttgat acttgcaaaa
    26761 tagaagcaag ttcttcttgt tttatgcctc tttcttttct tatttcttct aatctatttt
    26821 tcacatctat ccccctttaa tatctcaact acggaaagtc tactttccat aattatacaa
    26881 ctatattcca tttatgtaaa gcttactttc catatttaca aaaaaataac agactatttt
    26941 cagcctgtaa ttttagaatt tcatgttgtt tattaatttt aatgttattt attaattcca
    27001 tattatttat taattttaac ttggtttctg aattggaatc caaacttctg tagtataatc
    27061 aggagcattg atatcgccat tgggataaag ttcaatatct ggtaaattag catacacata
    27121 cccagaactt ggtaaccact cagtaataat tcttttttgc aattcctgta ttgccagagc
    27181 atttggcatt ggagaaacac attcaaatac tgcccatgtg cctgatggta ttaagtattc
    27241 atgagtatct tctaatacag gcttatctgt tggagcagca atataataat ctaaaccctt
    27301 actatttgta cacacactaa ctccaagcaa tccacaaggt tcattattta ttaactctga
    27361 aagtttatca attgttccat tttttatgca tttagcccac aacttaggaa ctttctcaaa
    27421 gcactcttct acaatcatgt tcatactttc ttttatacca acaatacgaa accctttctt
    27481 ttctacaata cgatattgca tttctatatt tccttttaca taaatgctta atgtcatctt
    27541 aggatatgct tttaaaacaa caccctttgc tctagctgca gatggagaaa tgttatgtat
    27601 attttgaaaa gctctattaa aagatgttgg tgaatcgtaa ccatacttct cagatagttc
    27661 taaaattttg atgttactgt tctgaagttc aaatgcagcc ttagtcatac gtcttcgtct
    27721 aatatattca gataatggta cttctgcaat atatgaaaac attctttgaa aatgaaaggt
    27781 tgaacaacat gcaatttttg ctgcttctgc ataatccact ccactttcga gattttcttc
    27841 aatataagta atagcttgat ttaatttatt tatccattcc atttgatatt acctccaagc
    27901 aaattataca gtttaataaa ataatatacc tctctattca tgcacaaaat tgtaagcatt
    27961 taaatttata agcatttttc aatcaataca ataaatataa aaattgtatt atacaataaa
    28021 aaagttcaat aacattatat tgtaaaatgt tattgaactt tttataaaaa ttaatttaag
    28081 tgtagttaaa ttaagtatta cactatctta tatattacaa tatcctacta tcttatagtc
    28141 ttctggcact ttataatctt tgtctggagt acctaaattc cattttaaat caaacatagt
    28201 tgcacttatt attgttgcaa aataaagcat aactatacca atgtctattt tttcttcata
    28261 taaattagta tgaccatctt ttctaacagc taaaactaca gtgcctccat caactataaa
    28321 tctccatggt tgtctattta atgtagatgg agctaatctt gcatagtgaa atgcatcaag
    28381 aagtgctctt tcttctaaga tttctatact tgcaacattt ccccattcgt tcatataaac
    28441 aacatcttct acacctagtc tagtagaccc cttatctgtt acaacttgca tatcagattt
    28501 tgaataattt tgcccagttt ttgtagcatt taatacttta gcattactta cattttctcc
    28561 atatccaata gctataattc ctgttacctc tttatctgaa ttaattccaa gtttttcttt
    28621 tacctttttt ccatcttcaa aagtaaccca acaagaacca attccaagtt ctgttacttt
    28681 aaagattata ctttctccta tgtaccctga attttcaatg taattatctt ttatgtcaga
    28741 taatattata atataacttg gagaatctat catatttcct ttgtaccctg ctactttatc
    28801 taaattatta aaaacttcac ttctattcat aattcttaca tcaacatcta tttctggaac
    28861 tagtttctta caagattctg agtatttctt aatttcacta agatattctt ctttaatatc
    28921 tgtgttctta tattctctaa cagactttct atttaatatg attgttttat aatccataat
    28981 tttatcctcc ccaaactagt attgtcttaa ttatataccc attaatatat tattttactc
    29041 atttatttaa taaataaaga ttacaatttt gtaattatta tttattaata atattccact
    29101 tttacattaa taatgaccag ttgtgcaaaa tccattgcca accaccaaat aaaaacatat
    29161 tataaaggta atataaaata acaaacaaat cttaacaaaa aattaaactt tttttacacg
    29221 aaagaaggct tcccgttgcc ttctttattt ttataaaaaa ataagctgtt tctaaaatga
    29281 tttcacattt ttgaaacagc caagttattc tataatgaca actataattt gaggatgtga
    29341 gggagagttg tcattataaa tttagggtaa ttatattatg ttttaagcta gttctttcta
    29401 tatttatata atacatttta tatatgaatt ttatatgaga ttggtataaa tgatatatga
    29461 aattacatat gtttatatta tattaaattt tattattaca ttttccacaa caatactcat
    29521 atgtctccac attatttgga atatttacaa atacaaattc tttacagttc tcacaatact
    29581 ttaatataga tatagttcca caagtgtaac attcaaatat tacacaatcc tcattttcct
    29641 ctactatttc aaacttttta ctatgttcac cacactctgg gcacttgtga ttatttacat
    29701 tcataaatac tcctccttat tagtatagtt acatgtcaaa aacttaatta atgtattcta
    29761 tattacttat tatatattct ataataaatc atattctaat ataataaaac aaattaaata
    29821 aaaaaaaaac cataaatttt aaatttatgg attaattctt gtaatgataa ctctatttga
    29881 ggatgtgagg gagggttatc attacaatag ggtattatat tatggttttt aagctagtct
    29941 ttctacacct catatgatac atatgctata tgaattttat atgattttta cataaatatt
    30001 ttatgaaatt taaatttttt agtcattttg aaatttgtaa aaagttctct aaaaatccac
    30061 agcatcataa acagccaaaa tttaagtaaa acatcataaa aaaatttgtc caataatttt
    30121 aacaagtaat ctcacctaat tataattatt gacacaaact taaataaaca atctataaat
    30181 cttctataaa tcttaaactt tccccctatt gatacacaat ttctagtttg tcaattttat
    30241 tttgcatttc taagaaaatt tcttcaacag aattgttaaa tatattgcct aaatagattc
    30301 ttttatcttt ttgaaatgaa taagatttta cactaccatc agaagaaata tataaatgac
    30361 tccactctgc tccatatttt gaaaacctct cctttgtatc tttaaacctc atatcttcta
    30421 tttttattgc tttttctctg tctcctctta ctacagtgtg accccttttt attaaactgg
    30481 ttatttttat atcttctttt aatttaatac gtgtatcatc attttttgaa tatactttcc
    30541 atatcacttt atgacgataa ttatctaatt cctttattaa gcttctatca atagtaaaac
    30601 tatctttagt taccacaatt aaatcaaaat ggtctaacat atattgaaat atttctctca
    30661 tacttttatt ttttaaaata tcctcaccaa taacctctat aaatctacag cctttctcat
    30721 acatgcagtt caataaactt gtgatttcag aaaaataatc atttgtatta ttatctccat
    30781 ctatttctat agtaaagtac aaaggagtaa tgtatgattt atttcctgtt atctcaaata
    30841 cacttgatag tgtctgtata tcatcttcaa acgttaagta cacattctca taaaacataa
    30901 aaaattccat aactttttct ttcatattat ggatatttct atatctattg gataatatat
    30961 ttattatatc gtcagtagta tttttcccat cacattcagc cagtataaca atttgcttcc
    31021 aacttaagct atccacattt ccgatacttt ttttatatcc atcttcttcg tcataaatag
    31081 gaccaattat aatgttttct tttggccaca gatgaaccct agttccatct tttaatttcg
    31141 gatatttatt ttttacagac tcataaaatc tacttgtatc acccatgatt ctttactacc
    31201 ccccatagtt taaatattct atgctaaaaa tagcacttta tttttattaa ttcaacaatt
    31261 attcaaaatt ggtcattata tatgtttaaa tggatttaac atcaacctta tttatatgtt
    31321 attgatgttt atatatgtta tataaaatct tatttctcat acttaaatgt aatcttaact
    31381 atctctggtt tacaattaag cctaattaaa acttttgagc ctcctaagcc tttatttaaa
    31441 atcatagtgc tattatcttt ttcatatttt ccccagtcat acttaggaaa gaactctcta
    31501 tttggagata atacacctcc aacaaaaggt attcttatta tacctccatg aacatgtcct
    31561 gctaaaacca aatctgctcc ccattttgca tatttttcaa agaaaaatgg tgtatgtgct
    31621 aaaagaatgt tatattcatt ttcattaact ttacctagat tgtcttctac aaaattgtca
    31681 cttagttcta attttttgtt attagcaaat aaatatggat agcattccaa tggtataatt
    31741 aaaccatata aattaagatg gctattacct ctatatattc ttacagattc attttccata
    31801 tttattattt tctttgaata tagttcctta aaataatcct tatatagatg tttatacttt
    31861 tttattaaag atttttgttc atgatttcca attatatgat atacttcata tttttcaacc
    31921 aaattatcta ttaaatctaa tgcaacttga aaatttttat tttctccatc tactaaatct
    31981 cctgttataa atataacatc tgggtttaat gattcaattt tatctatcaa taccttatta
    32041 tttttatcaa acaccttatt atgtaaatca ctcacttgaa ctattttaaa gttatcaaat
    32101 tcctttggaa tttttttgtt gaaaatagta tattctgtcg tttctatatg ctgagtttca
    32161 tacttataca gaatatacaa taatattaat actaatactg tcattgaaac ctttataatc
    32221 atattctctt cctctttatt ctattttgtt aatattatta taatgctttt atgttttttt
    32281 taaaacaata acatcatcac atacatataa atcttttcga cattataaaa ataagttatc
    32341 cttttctaaa attttcattt attttagaaa aggataacta taaaattatc tataaacctc
    32401 tatattgtga aatatagttt ttcctttatt taaattttta tatatatgct ctaaagttcc
    32461 atcaaaccta atagaatgtc cagactctaa aatataagtt ttcccatcca cattaaggtc
    32521 aagtttacct tctattacga gtacatactc ttctaaaaca tgactgtgtg tagatgaaac
    32581 atgagtacag ttttcctcaa gctcaattat aaaaagttca aaccttcttt gagggctaaa
    32641 agggtatatt ggatataact tcatgttccc tttttgctca acaataggct ctacttcttc
    32701 tttctttata acctcatagg tatttgtatt ttcatttaat agtgtagtaa aatttatttt
    32761 aaatccagat gaaattttcc ataaagtaga tactgtcgga cttgattcac ctctctcaat
    32821 ctgtccaagc attgctttac tgacacctgt catctttgaa gctttgtcta aacttatgcc
    32881 catttcttgt ctcaataacc ttaaattttc tcccacatta ggaaatttat tatccatgtt
    32941 aaaatcctcc tgatagctat ttgtattcta tgatttttac tcctgtaagt tctactatct
    33001 cttttaattt taacatatga ttgttacaaa tttcatcaaa ttcatatata taatcttcaa
    33061 gccctaatgc cttatattta tcgattccaa atttatgata tggaagtaac tccatcttgc
    33121 ctcctggaac attttgtttg acaaataatg cagtatttct tatattttct tcactatcat
    33181 ttactccata aataattggc actcttataa ccatagattt attcaacttt gaaagcctac
    33241 atatattatc taatataatt ttattactta ctcctgtata ttctttatga atattatcat
    33301 ccatagattt tatatctaca aatatgtggt ctattttctc aaatacatca tttaccttat
    33361 tccaatcaaa atatccacaa gtttcaattg caatatttat gcctttatca taaaaaatat
    33421 caactaattc tcttaaaaaa tcaatctgaa gtgtaggttc acctccagaa aaagttatcc
    33481 ctccattaga ttcaaagaaa aatataaaat ctttttcaac ttcctctact atttcttcaa
    33541 cactcatttc ttcggtcatt atacaaatgg catctttaag acataccttg atacactctc
    33601 cacataaatc acatttatta tttatttgcg ctctatcaaa tagtgaactt atattttgag
    33661 gacaaacatc tatacatcta ttacaggata cacatttatc tttcataaca cctaatttta
    33721 ctatgttact ccaggaatct ggattagaac accacttaca ttttaattta catccttcta
    33781 aaaatatagt agtccttatt ccatctccat catttactga aaaatgttgt acttttacaa
    33841 ctctaccttt tttactcata atctacctca taattaaaaa ttgctatgtg aatttctagc
    33901 tattatagca tcttgcattt ctcttgataa attaacaaat tgagtactat atccagcaac
    33961 tctcactaat aaatctttat attcttctgg attttcttga gcttttaata gagtatcatt
    34021 tgatatcgta ttaaattgta catggaatcc tcctaaagca aaatatgatt taatcataga
    34081 tgttagattt ctaagtcctc tttcagtttc caccaaatct tgattcagtc ttaaatttag
    34141 aagtgttcca ccagtatgaa catcatgatt tatttttgat gcagatttca ttgctgctag
    34201 tggacttgtt gtatcagtac caacaaatgg agaaactccc tctgtcaaag gttttgtcgc
    34261 ttttcttcca caaggagttg cgcctacgat ttttccagtt ggtacatagt ttgatatacc
    34321 cataaatgca ctattaaatt tagagccaaa aatatccttg tattttctag tttcagtata
    34381 ataaaaatca gaaacttcaa ttgctaatga atctacataa tcattatcat ttccatactt
    34441 aggaacatcc aacgcaagtt ttcttaattc ttcataacct tcccaatcat tatttagtgc
    34501 ttttgttaat tcttctaacg tagtcacctt atcctcaaat actaattttt ttatagctgc
    34561 caatgaattt gaaactacac ctaaccctat accagttaat acaggaccta tattatattt
    34621 tgctcctcct ttacttaaat caactccctt atccaaacat ccatctacac aagtagataa
    34681 aaatggtctt ggtaccattt ctttatgaat ttgttgagca acagtagttc ctataacaga
    34741 actttttaca agatatgcta attgctttaa aaactcatcc ttaagttctt caaaagaagt
    34801 aaattctgtg atattttttg tatctaaccc cattttttct ccagttaatc tactcttacc
    34861 ttcattcata gcatattcta aagctgctgc aaaattgata tttacggctg aagtccactg
    34921 tcctgttttt ctaaaatgag gaactacaca accacagtta ctccaatctc tagcatcttc
    34981 tgcatcatat ccatcttgta ataacatttg tgcccctgca ctatcgctgt gtatagcagg
    35041 gaaaccagtt ccttgtttta ccaatttagc aactgccatt acgaaattgt ctggtgctcc
    35101 ttgactcact ctaacactta atcctggttg gtgagttttt acactttctg tagcctttaa
    35161 acacatatat gagatatcat tcgttccatc agtaccattt ctctttttac caccaacagt
    35221 aagattttgg aattgattat atcctgcaaa gtaatttgct gtatttgctg atatagtcca
    35281 tacccattct gataacttaa tccaaagtgc ttctatcaat tcttgagctt ctgattcagt
    35341 tattttacct tctctagcat cattttcata atatggatac atatattgat caaatctacc
    35401 taaatttaat gccaatggat tttctgatag aataccacct aattgaacaa accatacaaa
    35461 ttgtattgct tcataaaaat tagttggagg gtttgctggt acattcatac atatctctga
    35521 aatttttata agttctaact ttctcttttc atctgtttct tgcttactca tctcttttgc
    35581 aagatttgaa tatctttgtg ccaatgtcat aataccctgt gcaactatag aaacagattt
    35641 gtaaaaatct atcttttcaa tattttctga aactgatata tctaattctt taattttttt
    35701 atctgcatct tccttaatcc ctttatatcc ttttacaaac aatatatctt gataatctgg
    35761 tgttacttca ccaactgcct gtctccactt agaatcatta tctattattc ctgtatctac
    35821 taatatctta gctgtatctt ctgggattct tgctaagaaa acttcttcca aagattttcc
    35881 cttccaatat ggaaatattt cttttcttat aaattctatt tgttcttttg atattacata
    35941 tgggtcttga gttcttttat caaaagtatc catttctttg tctacccatt gccaagaaaa
    36001 ctctggtgtc aatatccctg ttcttctaaa ttttcctgct gtacctacta ttaattcatt
    36061 ttcaaagatt tttataggaa gttctttaca tgtctccaaa aaagctttag ctcttcttat
    36121 acagatagct tctccctcag tttttttatg tgattctgta aaaattctag ccctttcaca
    36181 acatatcata ggtttagaat taatatattc ttgtctaaat gcttctattc tattagtttg
    36241 actcatttaa aatccccctt tggataatat atactacatt tttgtatgtt ataacatact
    36301 ttaattatat tatactgtcc tttagcataa aatggaagca aaataactta ttttttttca
    36361 tctaccttga acacctatat attaatactt tttttgttaa atttataaaa tctaaaaaaa
    36421 ttttctatga tatattttct atattgttat agttatgtct aatatactaa tgatttgaaa
    36481 tatcaaattt gtatactaga cttagtttta aaaccttagt tgattgttta actttgttaa
    36541 cttcaacatg tatatccttc atataaggaa gctctacaac acctactccc ttattaaagt
    36601 cttcttcaac catagaaaaa atttctttct cagttaagtt cgtatcagtc aatgatttaa
    36661 ataaattgta tataaattta acatatttat cactctcaga taacttatca tcttctggat
    36721 actctttagc acagagaata tctattgtta cttttccttc tttatcgtct tcagacatag
    36781 aatagaataa acttcgaata tttttttcag gtggtttttc agcaccattt atagatacta
    36841 caaagctacc atctgatttt gagttagtaa tactataacc actgtctatt atagctttcg
    36901 aaaatctttg agataaatct ttttttactt cttctctacc tttcgcatca ttaatctttt
    36961 gtgagtaatt attaaatagc tcaatagatt catctttttt atcttcaact tgttctttca
    37021 atgaatcttt actaatttgt tctgagctac ttaagttctt atcagataca ggagacatac
    37081 accctaccat caatgctaag ctaagattta aagccacaat tattgccact ctatttatat
    37141 tcctttttac tttcatacac aatcctccca tcacactaac cgctctaaag tattattcat
    37201 tgcactagaa tatatttata ttttctttat attaaagatt tattattcaa tacatatcac
    37261 cttcctatcc aattcttata acttactatt agtaaaatta taagctcctt aatacagaaa
    37321 taaggatgtt atcttttgtt attaaaagat aacatcctta tttttttgta tcaatacata
    37381 tgtcccaact ggtaacttaa tcgccccaac tgtcagtatc ttggtccaat ggtatatata
    37441 tatttagtat aaatttatcg atactatttt caaataataa ttctccatta tatttttgta
    37501 aagaagattt aatactctga atacctattc catgtacgaa cttatccatt ttgtttgtta
    37561 acaatatatt tttattaaaa gtaagctgat ttagtttact attttcacat ttaagtacaa
    37621 aaaatgacct tgttatagtt cctttaattc taatatattt attaatattt tcatccacta
    37681 ttttatcaca tgcttctatt gcattatcca aaatattaga aaatatgctt gacacatcta
    37741 taggttttac aaaatttact tttgaaaaat ttatagagca agtaaattta attccttttt
    37801 ttaaacatac ttcactcttt tcgttgatta taatgtctaa tatcatattt cctgtattat
    37861 agatatattt aaatgttttt atttcatctt ttaaattgtt aacatattca ttaatttctt
    37921 tgctattgtt tctaaggttg tctatacaat aaatgtgatt atttatatcg tgatatagtt
    37981 tcttaactcg catatgagat tcttgaatac ttaaataatg cgcatattgc atatctaact
    38041 tattttttat taattcagct tgagatttta atctattctc ttttattatt tctttaaaca
    38101 atagtataag aaatatacta ctagctccta ccaattttgg attaacaaaa ttatcaaaat
    38161 agtatccttc tgaatgtaat gacccaaacc gttctaattt ttttaataca taatttacaa
    38221 gcatattcat tgtattaact aataaggcaa ataataaata tacataattt ctcttatctt
    38281 ggctaattaa ttttatagac tttctaaaaa agctaaatat aagatatata agaataatta
    38341 ttaaattact atatatctga atttttatag attctaagta aggtactaat aaagattctt
    38401 tagatgaaat aacattacct gtaattgcaa aaaatagtat tctatatata acagcatcca
    38461 aacatttata atatacacta aatagataaa agaaaatgga atacttaata taacccatct
    38521 tataaaaata attatagtat cctccccaag caataaatgc taatatataa aataaatagt
    38581 ttatattact aaagtaattt cctccattaa ataatctact tatctgaatt ataatataaa
    38641 taagaaacaa gacaatatag aatactattt tttcattttt tttactatcc tttttataaa
    38701 ttaaaattcc gttcattata gaaaactgta taaatataga taaaactact aatagctcag
    38761 tcataaagtt tagcatattg tatcaccaag aaattttaag aatttctcct taacttcttt
    38821 atatctatat ctactaatag gtacctcttc tccactttcc agtattgcag tattaggctt
    38881 tatattttca acatatctta aatttactat aaaactttta tggcatctta taaatttata
    38941 tggatttaat tctttttcta ttttgcctaa actatatttt atatcaaaat tcttgtttat
    39001 tgtgtgtatt agcatatctt ttttttgaac ttctatatat tttatttcat ttaaataaat
    39061 cttatatgta ttagacttat tttttattgt aatatgactt tccttattta tttcaatatc
    39121 tttgatacaa gttagcacat gtttttttag ttcttccaac tctattggct ttagtaaata
    39181 cctataagct cttacctcat aaccttcttg cacataatct attaatgaag ttacaaatat
    39241 tatttccatt tcattgtcta cttctctaat ctttcttgca gtatccattc catttaattt
    39301 ttccattttt atatcaagaa gtaatatatc tatatctttt aaattacttt ccagtaactc
    39361 ttctccagat atatactttt gtatctcata ttctatactt atatctttta atatattctc
    39421 aaggtaatct tctattaaaa gttgtgtttc tttttcatct tcacaaactg ctatcttaat
    39481 cataaaatgc ctccttacat aatttctagt taatacaatt aaaatattta taatatattt
    39541 aaagataatt ttgtatatct gatactttag gataacattt ttaaattatt tttatcaata
    39601 ctcaatccca tacaactatt atttgatatt tcaatttaaa gacagaaatt actataatta
    39661 aaaacagtac ttactgacaa aagaagatgt cttaaaatat taaaaaaata attttaggac
    39721 accttctttt atttatttaa actttttaag ccttaaataa tacattaatc tcctatataa
    39781 ttgtactgca tataaaatca acaatataat ctgtagtaca atagcagtta cagatgctcc
    39841 ataaccacta tataaatttc ttatttcaat attcaataaa tatataaata ttactactaa
    39901 cataaagaat ataaacatat tcataaataa aattgacttt actttatttg ttttatcaga
    39961 atcactatat aatttaggag gtatgtcttt gtattctttc gaccatatat accatgcaga
    40021 tgtacccata aaactaccaa tactcctaaa tacaagattc cagccatttg atttatgttc
    40081 atcaaaataa ttattctcta catcatagta gtaatcaaca gtgtatttta tttttcttgg
    40141 acttccctta tgaaaataaa atattcctcc aaatttattt atcttatata aattatatcc
    40201 tttagcttca atatcttcta accatttctc tatcttatca ggtgaactat accagtcaaa
    40261 tttgaatttt attttctttt ccatagcact cattctccaa aatgatattt ttaaatagct
    40321 taaaaatcta tttaaataat tatatcattt tgatactaat tttaggttac aatcatatat
    40381 ttaaaagtta tttaaatagt aataaactaa tagccataac acccattcct gcaatcaatc
    40441 cataaataga taaatgatgt tccccgtact ctctagctga tggcaataat tcatctagtg
    40501 atatgaatac cataattcct cctacaattg caaatacaat tccaagagtt atatcattta
    40561 aaaaatttct aagaagtaca tatccaataa tcgctcctaa aggctcagac ataccagata
    40621 aaaaggaata ataaaaagct ttctttttat ctcctgtggc ataataaact ggtacagata
    40681 cagatatacc ttctggtata ttgtgtattg caattgcaat tgctatcgga atagctattg
    40741 taacatcatc aagagctgat ataaatgtag ctaatccttc aggaaaattg tgaattgcta
    40801 tagccattgc tgtaaatata cctgttctta aaagagactt attttttttg atattctttt
    40861 cttctatatt ctccattttc tttatttcat gtggattttc ttcttgtgga attagcttat
    40921 caataacagc aatgatagcc atacctataa aaaaagctat tacagttgac caacttccta
    40981 atttctctcc catagatttt gtcaaagcat cttgtgcttt aggaaaaatt tctatcatag
    41041 aaacataaat cataacacca gcagaaaatc ctaagcttat agaaagaaac ttagtatttg
    41101 tttttttagc aaaaaatgct atacaacttc ctataccagt agataaacca gccaataatg
    41161 ttatcaaaaa tgcaaatatt acattattca aataaatcac cttcttttta attgatattg
    41221 attatcattt tctttatgct atcatatata ttttatatag tcaatattta taaaaaatat
    41281 acacaataaa aaagcagaga tataaactta gtctctgctt tttctttata gtatattaaa
    41341 attatttatt taagaaatcc actgcatatt gcacatataa agcagttcca atttctagag
    41401 catcttcatc tatattaaag catccatgat gatgaggata acaagcacct tttgactcat
    41461 ttctagctcc tacaaatgct agtgcaccag gtgctatatt cataaactca gctaaatctt
    41521 ctgctcctgt tactttttca aatagtgtta tacagtcttc tccaaatagc ttaattgctg
    41581 catctgtagc tatctttgaa cattctttgt catttataac tgctggtgtt aagtacccat
    41641 actctaattc agcatctgct ctatatgctt ctgctgtaga ttttgctata cgttctaaaa
    41701 ttctaggaat ttgctttcta agctctggat taaatagcct tattgtacct tctaagatag
    41761 cttcactcgc aattacatta aatctagttc cagaatttaa aactccaaca ctcacaacta
    41821 atggttccag aggacttact tctctactaa ccatagattg tagattcata actattgctg
    41881 aacttgcaag cactgcatca acaccttgat gaggaagtga accatgacca cctctacctt
    41941 ttacagtaat tttaaagaaa tcagcagaag ccattcttgg tccttcttct accgatatgg
    42001 tcccagattc tacatcagtc caaagatgta ttccaaacac actatctaca ccttccatag
    42061 caccatcttg aatcatagct cttgcacctt taccaacttc ttctcctggc tgaaaaaata
    42121 attttacagt tccattgata ctatccttaa tatcatttaa cacttttgct gcccctagaa
    42181 gcattgatgt gtgaccatca tgaccacaag catgcataag tccttcattt ttagatttgt
    42241 attctacatc agtgcattca acaacttgta gagcatccat atcaccccta agtgctacag
    42301 tctttcctgg attagctcct tttatagttg caattacacc tgtacctcca gctgatacat
    42361 atggtatccc tattttatca agttcttctt taactctctt tgatgttcta acttcttcca
    42421 tacttttctc aggattttca tgaaattccc ttctaagctt aattacatag tctttataac
    42481 tctttgttat ttctttaata tccattccat acctccaagt agtacacatt cttcttattt
    42541 aaaatacttt ttatcactca aatactatat tagatttaca aagatacccg ctattactac
    42601 agaagctatt gtaactgtag taaatcctcc aacaagcatc tttggaagca tcttatccat
    42661 taaaaattct ttttcttctg gtgtttcagc caaagccttt actgcctctt cagttaatat
    42721 atagtttggt ggaaaaccat aaagtgatgt aagcgaaact gaaaaagcca tttctttact
    42781 ttcacctaaa agcttaccta ctataataga gaatattccc atacctatta caccaaatat
    42841 tatgattcct acaagaggaa ctgccatttc aacaagcatt gctggtgtag cttttgctaa
    42901 ccctgcaaat ataaaagcca tcaatgatgt cattaaccat ccaaatgaac cagatttatt
    42961 aagtggtttt ctatcaacta ttccaagttc tgatgctatt acaccaaata ttaaacatat
    43021 aacatatctt gatacaactt catttgtaag atttgtaaat tgtactgcta accatgctac
    43081 aaatcctaat ctaagtatta tcatatatgt cgtatcatat ttttctggta agtctggaat
    43141 tatcttaaat ctgctttttt gttcaggtaa atccttaact ttttcttcat ctgtatttac
    43201 agttactttt ccacttctaa agtctgataa aagtcttttt ccttcttttt taagcattaa
    43261 tgctgtaata ggataacccg caaatccttg tgcaacatac atcaaaattg caagtactga
    43321 taaacttgca agaccttttg ctgtagcagc atctgccatc attatagatg caactagccc
    43381 tccagtaaga ggaggtgtag ctattactgc tgtatcccat ccaaatacta ctgtccctaa
    43441 tgccaaagca cctacacata ttcctactat tcctgccaag gctattacta ttgttttcca
    43501 ttgacctgct aattccttaa tactcatcat agttcccata tgagttatta acaaaagcat
    43561 acctaattga gctaatggtg ttcctaaagc ggctaagtcc acaatatttt ctgggaaaaa
    43621 agtccaaaat cctactataa atataattgc tgatacaaaa accgacggaa caaaagcttt
    43681 agtttttgct gaaactatat ctcctatcgt cagtgatact aaaactagac aaaaagctgt
    43741 tattgcctcc atacaaaatc ccccctcata ataaatatat ttttataaaa tgtatgtata
    43801 gttatccatt attttactac ttttgaaaaa catttcaagt caaaattcga tttttttcat
    43861 aaaattcgat aaattccata aattaaagtt agttttctaa attattcttt ttgtaaaaac
    43921 gttatcccga ccattggcta tttaactcta ttcttacaaa gagaattaaa tgtaatttgc
    43981 aaaaaataaa acataggata cattttattc ataaaacatc ttataaatat aaaatgaatt
    44041 gtctttatga atcttaatat atcctatgtt tgtaagttta atgtgtatgt tagctatggt
    44101 gtaaaatttg tatactagtt attgtgtaac ctactatata ctccattttt gtttactagc
    44161 tcttcatgag tacctctttc ttcaattcct ttatctgtca atactatgat ttcatcagca
    44221 ttttttatag tagtcaatct atgtgcaaca actaaatttg ttctatcttt acttaattcc
    44281 tctaaagact cttgaatttc tctttctgtt acattgtcta aagcagatgt agcctcatcc
    44341 aatattatta ttggaggatt ctttaaaaag attcttgaaa ttgaaattct ttgtttttgc
    44401 ccacctgata attttacgcc tctttctcct atataagtat catatccatc tggcaaagtc
    44461 tctacaaagt catgtattct agctttttta gcagcagcta tcatttcttc atctgtagca
    44521 ttagggttcc cacaaagaat attatctctt atagttcctg taaataaaaa tacatcttgt
    44581 tgaactatac ctatattttt tctcaatgat tttaaactaa catcttttat actctttcca
    44641 tcaattttta tatcaccctt atcaaattca taaaatcttg gcaatagatt acataatgta
    44701 gtctttcctc ctccagaagg tccaactaat gctatagtct taccagcttt tatagataaa
    44761 cttaaattat ccaaaacttg agtcttatct tcatatgtga aagatatatt ttctatctca
    44821 atgtcacctt ttacattttc aagttcaata ggatttttag cttctttttg atggtcttgt
    44881 tccattatct ctatgaatct tttaaaacct gtcataccat tttgatattg ctctgtaaag
    44941 tttattaatt ttttcatagg ttgtataaac atttttacat atagtatata agcagcaaaa
    45001 tcacccaaag taatctttcc tatataagta aaataaccac cagctattac aactacccac
    45061 tctaagatat ccatgtataa attcatacca gagtaatatt ctgccattac cttataagaa
    45121 tcttgtcttg ctcttctaaa taatttattg cttcttacaa acttatttaa ctcttctttc
    45181 tcagtacaaa aagacttagt taccttcata cctgctatac tattttctaa agtagcattt
    45241 acatcaccta tagtaactct actcttcata aaagcaatat tcatcttatc ttttttagct
    45301 attgcaaacc aaattataaa cggtaatata gcaaatatta taagcgtaag aggaatattt
    45361 atatctataa gtataaagaa tgaaccaacc aacattacta tagaaatgaa taaatcttca
    45421 ggcccatgat gtgcaagttc tgttatatcc attaaatcat ttactattct agacatagtt
    45481 actccagatt tgttattatc aaaatacgta tttggaagtc tttgtaagtg tgtaaatacc
    45541 tcatttctca tatcagcttg catatctaca ccaataacat gtccccaata ctgcataaaa
    45601 tagttaagcc ctgcttttgc tataaatata agtataagtg ctactgcaaa aactactaac
    45661 attcttaagt ttttatttgg aacaacgtca tccattatat ttctagttat cataggataa
    45721 actaaatcac ataaggaaaa tagaaaagct gctataaggt ctagtgtaaa aattttctta
    45781 tatggcttat aatatttgac aaattgtttt atcataagta ttaaatccct cctttattag
    45841 tacttctatt agtacttcta aaaaataccc ataaattagt ataacataac aataacttta
    45901 aatcttttat aaacttacaa agtaataaca atctttttca taaaattgaa gatttatatc
    45961 atatagttgt atacttgaaa caacataaaa agagctatat ctctatattt aaaattttat
    46021 aaagatacaa ctctatattt aatactaaat tttttttata aatacaaaac tacttcaatg
    46081 catttaatat ctttttatct aatgctgttg tatttatacc tgttatatat cctgttgcct
    46141 ttattgtagg tatatcataa gttgttggta gtatagtagt agatacgatt aaatcagcac
    46201 cttcttgttt tgttgaacat tcagcaattt tacattgctc aacttctgct tgtatattat
    46261 tttctttaac caatctttct actctgtcac aaactattgt tgatgttgcg attcctgctc
    46321 cacaggctac taatattttt ttcatatatt gtcctcctac aatttcttta atattttata
    46381 actcaaaata aaattgataa atttcttata tctttattta tataaataat tatatcattt
    46441 tatataagaa gaacatctta aaattattct tttaatatgt tttttatttc aacattactt
    46501 atacttaaaa tttcattttt tatacaagac tctatgtact ttgatatatt tttataatca
    46561 tttaaattaa actgttcaat attcaattta tattctatat cactgacaat acctatcaaa
    46621 tcagacttat tagataaaat atcctcatac ttaccttttc tagttacttc caatctttta
    46681 aatctataat ttttatatcc ttctatgata atcaagtcca tatcttcata taattgaatc
    46741 attttatata atggattctt ctcttttagt tcttcaatat atgctactcg tttatctgat
    46801 attatacaga cttttctcgc cccagatttt ctatgtttat aagtatcttt tccttcctca
    46861 tccatatcaa aatcatgaca ggtatgttta ataactccaa cacgataccc ttttttattt
    46921 aattctttta ttatgccttc aatcaacgta gttttaccta ctcctgaata tgagacaact
    46981 gacaatatat tatacataaa attgtgtcct ttcataaaac tatctaataa caacatccac
    47041 taattgattt tcttttattg tctcattctt tttaatctta atcatacaat tacttcttag
    47101 agttgcagat agtctagctt ttgcatcttt cttatcattt agctctacat acaatttacc
    47161 ttcacttgta tatagttttc cacttacaaa tctatcttta tttgaaagtt tattaaattc
    47221 tcctttaaat atagctttta tatgatgtgt tcccttctta tatgttaaat actcaataac
    47281 aggaactatc acattatcaa ataccactat tgctgcatgt ggattaccag aaagaccaaa
    47341 taatagcttt tctcccaatg tacctacata acaagctcca ccaggtttaa tgtttatctt
    47401 ccaaaataat tctgttgccc ctattttttt gaatacatct ggaattaaat ctttatctcc
    47461 aacagaaaca ccacctgtgg taattaaaaa atctacactc tgtaacatat tctttacctt
    47521 tttttctaaa tccaatatat catcagaaca attgcatatt gtatctgctt gtattccaag
    47581 ttttaataat cttgaatata aggtatatct attactatcg tatattttac cattctctaa
    47641 agtctcattt atatcttgta gttctgtacc tgtattcaaa attccaactt ttaaatcatc
    47701 ataaacagtt actttggata ttccaagact tgctaatact ccaataccat catatcctat
    47761 attctgattt ttattaataa tcaattgccc cttttttata tcctcaccct taaatatgta
    47821 attatcgtat tcctttaatt ttatatttaa agttatcata tcacctataa ctgttacatc
    47881 ttcttttttt attacacaat ttgcaccctg tggtatcttt ccaccagtca ttatcttcac
    47941 tgcttcattt ttatttaata ccctattaaa tacatctcct gcatacaaag tccctataac
    48001 ctttaaattt ctattttcag aatttgcatt atatgcataa ccatcatagg gtgacctatc
    48061 aaatggagga ctatcaattg ttgaatatat atcttctgca actaccttat ttactgcatc
    48121 tataagattt actatcttga ccctgtttat tggtaaaaca tttttttcaa taatttttat
    48181 ggcatcttct aattctatca ttttaaatac tccccaatat attttttatt taagatattt
    48241 ctatgtaata tattatagat tataaaagtt ggaaatactt ttatcttata tttaattata
    48301 actaatagtt atctataagt gcagttcaaa ttttataaat ctaataaaaa aactgttccc
    48361 agctagaaat ttccttctat cttgaaacag catcatatgc tttagaatat tttattctaa
    48421 taaagttcct tttattattt ttacaatttt atcactttca atagttttta tagattttat
    48481 tttgttatcc acaatactta ttgtaagtac ctcttttttt aatattttgt tatcttcttt
    48541 caatctataa ctcttaacta ctttactgcc ttcatgatta tatgctgtta aatcataatt
    48601 cgcatctcct acaatttcat ttattctgga atcttcaaca ccaacatact ctcccaggtc
    48661 aatatgtcta aaattttcta gtgatacagc cgatttttca tggtcacttt tttcaatcac
    48721 tatactagat tcagcatcaa tgactgatat accttgtgat gagaaagaat tggtttcaac
    48781 attgacaact ttattttcgt taatatcaac atataaagca cttccatcta gttcatcatt
    48841 tccagtatat tttggataaa ctaatgtcat ataacttgat gtatttatat cttgcattgt
    48901 atttgattct tttaaaactt taggttttat ataataaaat gtattataag gtatacccat
    48961 attctttata atgtacttat aatctttatt cataatttca ttaacatcat tttgaacttt
    49021 tgtcatagtt ttttgctgtg ttgctttact tgctacttga tttttctctt tagtattttc
    49081 tttatgacat ccaacaagta taatacctaa aatagttaca caaactaatg acctttttaa
    49141 cttcataaat caatcctcct ttcttaaatt ttatagtatt tatctatatc tcaatttaca
    49201 gttatctctt ttttcaataa ttatatttat tatattataa aataattata taatatttat
    49261 ttgaatttaa taagattaag aagctaattg taatttttct gtaataaaaa acactttaaa
    49321 gttgaatttt gaaaattcaa tttacgatat ttttattgta agtaccttac aacattatac
    49381 caaattattc ctaaacaatc aaaaactcca tgaatattta aaggttttct attttaaaaa
    49441 tcacctttga ctattaattt atcaaatatg ttataatagt tttagataat ttaaggagga
    49501 ttaaataatg gattttaaac aacttgaagt atttgttgct gttgcaaaac atcagagttt
    49561 ttcaaaggct gcaagagaac tttttttaac tcaacctact gtaagcgcac acatacagaa
    49621 tttagagaga gagctagaaa ctgttcttat aaatagaagc aacaaagtta ttacactcac
    49681 aaaatctggt gaaattcttt atgaacatgc tatatatata ttgaataatt gcaaacgtgc
    49741 aatttatgat ataaaagaat attcaggaaa aatagaaggt atcatagata tagcatgtag
    49801 ttccatacct gaaacttata ttttacctga ttttatgaag agtttttcta tgagttatcc
    49861 agatgtaaaa ttttccataa gccattatga ttctcaatat gctatatcag aaattttaaa
    49921 tgaacgaata agctttggat tagttggttc taaaatcaat aatcctcaaa tagagtacct
    49981 agacttatta gatgatgaac ttgttcttat cactccttca gattttaaaa ttgataataa
    50041 aaataattgt atcgatatag gagaattggc ttatctaaat tttattatga gaaaagaagg
    50101 gtcaggtaca agaaacttaa tactaaacac acttagtaaa aataactttc cagtaagtaa
    50161 attaaatgta atcgctcatg tagaatcaaa tgaggctatt aaggaaatgg ttagattagg
    50221 tcttggagta tcctttatat cgtacatttc agctatcgat tatctcaatg caggtaaaat
    50281 aaaatgttat aaaataaagg atgttgattt tactagaaag tttttcttca tttactctaa
    50341 aaagaaaact ttttccccat tagaagataa atttctaaac agattatgtg agtatttcga
    50401 aattataata taataacttt aataaagtag tgcttaattt tgagtttata actaattaat
    50461 aagctaatta taactatcac ataaatgctt ataaattatt atgaaccatc tttctttttt
    50521 atttaattta gtcaaaaaat ccctcgttca aatgaacttg ggattttttt atttatacta
    50581 ctccaatagc agccaatact atacaaataa tcataactga aattaatatc gtagttgtct
    50641 ttaccttttt tcctaataac caatacataa taccgaatat catagctgga agcatacatg
    50701 gcattatttg gtctaagtaa gtttgaatag gctctgccca ttctccacta cctacattaa
    50761 cactaagttt taacattaca ttagatgcag tcatacctcc aattaccata agccctaaca
    50821 ttgaagctgc ttccataact tttgaaacta tacttgaacc actcacatct ttaaagaatt
    50881 gagttccata cttaaatcct ttatctagac atatatagcg tataataaaa tgaggaacat
    50941 ttattattaa aaggaataaa atcggtccca ttatgttacc ctgagaagct aaagctatac
    51001 caaccccagc tgctataagc tttaatgttc cccagaaaaa tgaatctcct atcccagaaa
    51061 ctggacccat taaacttgat ttaacagcat ttatactatt agcatcaaat tctttattct
    51121 ttgcattttc ttcttccata gctccagata tacctaccaa aagagtactt atatgaggag
    51181 taactgacat aaattctaaa tgtcttttta aagccttaga tttcttttct ttatcatctt
    51241 tatataatct acggattatt ggtgccatca tgtatgcata tgctatattt tgcatacgtt
    51301 cgtagttcca agatgaatct aatgtcaatg accttctaaa acatttccaa aagtctttcc
    51361 tcgttatttt actatctggt gaaattgtct ctaatttctt agaactcgtt gtcatctact
    51421 attacctcct tctctcctac aaagttaaca tatattaaag ctattgctaa tccaaacaat
    51481 gcaactcctg ttactgttat gtttaggtaa gcaaccaata taaatcctaa taataaaaat
    51541 gctactgttt tcttattaag catcattcta gctaacatgg caaaacctat tgctggaatc
    51601 acgcctgctg caacatccat tccatgagtt acatatgatg gtataaatga aagtattttt
    51661 tctattactg gaacacctaa tgaaaatcct atacctacta ttattgctaa tattaattta
    51721 tttcctatac caaataataa ttgcacacgt tctacgcctt caatattccc ctcttctgca
    51781 taacggtcag caatatgagc tccccatgta agtactactg tcattaagaa gttatctata
    51841 agcaatacta gagttgctat aggaactgca agtacaactg ctgctgatac atcttgaccc
    51901 gttaatatta caaacgctgt ggcaataata gaaccagaca caaaatcagg aggattactt
    51961 gccccaacag gaaatgcacc cataaatact aattctaatg ttgaacctat tactatacct
    52021 gtatgaagat tacctagtgc taaaccaaca agtggtgcaa caactatagg tctattatgc
    52081 attgtagaac ctacaaaact atgcatatat gcaaagaatg caattagagt tatcaaaata
    52141 acttgtgtaa attccatttt catcccccta aaattatatt aatttcatta catttgtagc
    52201 atcatcatca ggaactaatt gtacaaatac atttacgcct tctgaatcta actctttaat
    52261 catctttata tcatcttttg atacatgcac tgctttagat atattttcac gattatcatc
    52321 tgattttgtt ccaccaaggt ttatagattt aatagctttt acctctttag caagtctata
    52381 aacatcttct acagattcac aaagtatcaa taagttgtat ttatcagtaa cacctgagtt
    52441 aagtgctttt atagaatctg ctatgctttt cattactaac ttaacattag atggtttagc
    52501 cattttaagt cctgccattc tcaattcatc ttttaataag tcatcacttg ctatcaatat
    52561 acagtctgta cttaaaaact ttgtccatgt aaatgctact tgtccatgta taagtctgtg
    52621 gtctactctt actaatttaa tcattataat tcctccctaa tttttttgat ttcatccatg
    52681 aatgttttta cgtgttctac actaacatcc ccaaaatctt tgtaattatc tttaaagtaa
    52741 cttcctatta ttgccatatc tcctaattta agctgttttt ttgcattttc caatgtaact
    52801 ccagcagcta taaccaatgg gaagtctcct aaatttttac gaaacagttc tattttttcc
    52861 attgatgttt cttgacctgt agcattttct gtaactgcta tagcatcaca tcttgtcatt
    52921 cctattttta aatcttcttc aacatcattt tctgataata ctggctgata tttaaaacgt
    52981 acgcctccaa ttaaatacgc tgggcatttt gaacgttgta atttaaaaaa ctcttctaaa
    53041 gtagcttcat ctctaggttt aacatgacct actacagaat caacctgtat ataactagca
    53101 ttatattttg ttgccagttc aaatcccata gtatcaacat ttaaacagtt tactccatat
    53161 ggtattgata aattagcttt tgatacatat tcaagtattc tttctaaatc ataataatta
    53221 ccatagtaat tttctaacat tattccatct acaccatttt cttcaaagat tgtaatctct
    53281 tttttagctc tttcaaagat atcttctgga gtatctcctt ttaagtgtat cattgctata
    53341 attggttttt tacttttaaa tactgataat attccctttt ttttcataaa ctaaaatacc
    53401 tcttcttctt ctttaatttg taatgtcacg ctttgtattc ctcttctaga ttcttccact
    53461 aattggtcta tatcttcaac tgttaattca tcagaaaacc ttgtaagaag ttctaatacc
    53521 atattcaaat tcattccaga aaataaccta acattatgta gattagttaa tcttaacatt
    53581 gctgtacata cacttgctcc atataagtca gataaaatta tatattcaca ttctttatct
    53641 tctgatattg ttttttctaa ttctaaagca aaatctgaag cactttgtcc agggtacaaa
    53701 ccatacgaac tgacacaatc tgctaaatct cctactatca tttttactgc atttaaaagc
    53761 ccttttgaaa agtctccatg agatgctaat attatctttt tcatactcat cctcctacta
    53821 aattatagat tatatttctg ctgatactgc atatttgtac ttatcacttc ttataaattg
    53881 ctcattgtaa tataagacat cattattttc tgtgtacacc gattgtctta ctttcaatag
    53941 tggcatatta cttgcacatt taagatggtc agaatattct ttgtttgaat gttttacttc
    54001 aaatatattt tctactcgtt taggtaatgt gcttatatta ttagatataa cctccattaa
    54061 agatttatct tctaattctt cttttaataa aaacatgtaa tctattctaa aatagtcaac
    54121 ttcaaaaata acaggtactt catctattaa tctaagtctt ttaatacata ttaccttctc
    54181 ttctagttca atacttaaag cttcagctac ttgcttatct gcttttttta ttaaaacaga
    54241 gattattttg gtacttggtt ttgcattaat acgatgacaa gaattagtaa aactatttcc
    54301 tgcacatgtt gcttctattc tctctggtat tgttacataa gtccctttac cacgtttttt
    54361 acataatata tcttctttta caagttcatt aagtgcattt ctcacagtta tacgacttat
    54421 attaaattct ttacataagt ctccttcaga tggaagttta tctcctggtt tatatatgcc
    54481 agatgctatt tgttttttta tgttgtcata tagttgttga tataaaggaa caaaggaatt
    54541 tacttctaaa tccatttctt ttttttgtct cttttcatcc attttgctca cctccctatg
    54601 taacattttt ataacattat ataacaagtt ctttattaca tattataaca agatgaaatc
    54661 gttgtcaatt tttttttaaa taatttttaa tttgacagta ttttctttta ttttctctag
    54721 tgtgacaaat tgctattttt acataaaaat aagactgttg tacaacagat taaattgttt
    54781 atacaacagc ctttattcac ttattacatt tatattttta cttataaatt tatattaaaa
    54841 aatgccttat atcccttata catttcatat atgtctactt tagagacaat ttcatgtggt
    54901 gcatgcatat ttaaaactcc aacaccacag tctataacct ctgcaccttg atttgccaat
    54961 atatgggcta tagttccgcc tcctccttgg tctacttttc caagttcagc agtttgccat
    55021 actacatttc ctttattaaa aattctcttt acttctgaca taaattcagc attagcatca
    55081 ttacatccac tctttcctct tgaacctgta tacttagtta aaactactcc atttcccata
    55141 tatgccgaat ttctcttttc atatgcttct ccaaaatttg ggtcatatcc agcagaaaca
    55201 tcagctgata ataccttact atttgctaaa gctcttctta ctttaatatc acaataatct
    55261 ccttctaaag caatcagttc agccacagta ttttcaaaaa actttgagtg catacctgta
    55321 ttccctttag aaccaatttc ttctttatct acacataatg caactgaagt aaattctggt
    55381 tgttcagttt ctagtatagc ttttacagca gcatatgaac ataccctatc atcatgccca
    55441 tatcccaaca ccatagacct atcaagccct aaatctctag ccttaccagc tggaactact
    55501 tcaatttcag cacttaataa atcttcttca actatattgt atttctcatt taaaatcttt
    55561 aatatatttg ctgttatagg ttctttttct tcatcttcta aaggaatatt cccaattaat
    55621 atatttaaag cttctccact aattccttct gatagtttct tttgcatttg gtctccagcc
    55681 aaatgaatca ataaatcagt tacacaaaat actgggtcac tatcttcttc cccaatagat
    55741 atgtccactt ttgttccatc atttaatata actataccat gtaaagcaag tggaatagcc
    55801 gtccattggt atttttttat tccaccataa taatgagtct taaaaaaacc tagattactc
    55861 tcttgataca gtggatttgg ttttaaatct aatcttggcg aatctatatg gcttcctata
    55921 atcttcatac ctttttctat ataattttta cctattacaa aaagtgctac tgccttctct
    55981 ttatttataa cataaatttt atcaccacaa cttatgcttc ctttttccat agcttcatct
    56041 attgaaatat agttattttc tttagccaat tttataattt cttttactga aagtctttca
    56101 gtctttgact tacttaaaaa ctccatataa ttgcgagaat attgcataat ttgttcaata
    56161 gtattttctt ttctttcaaa atcccaagca ttcttaaatt cgtactttaa gttcatattt
    56221 tcctcctact aagttctaat ttttattgtt tttcatgtat tgctcatatt cttctggtga
    56281 aactactttg acactatcta gtcttgatct aaagtgggct ctaaagtttt ctaaatattc
    56341 tttccttaaa atttctcttt ctttgatttc atcagcagaa aggattccct ctttattttt
    56401 ctttgctaat tcattaatcc tatctaattt cttcttgtca aacatttttt cctcctaaaa
    56461 aacctctatt tatttaataa aataatttat tgctttttat atctaacttg tttttatatt
    56521 cacaaaaaaa ctcatctata ttatcactta ttatagatat tcccttttct agttcttcca
    56581 tgcttggacg agctatattt atcctaaaga atctatcatc cactagattg tcaaaaaaat
    56641 aagtccctgg aagcattgac actcctttgt ttaacataaa atttgtaaat gcttgagatg
    56701 tatatcctct tggtaattct aaaaaaaagt ttattcctcc acaagatttt ctaactttta
    56761 atttaccact caatttgtca ttaatcaagt tttttgccaa tttatactta tcagtatata
    56821 tcttctctat atgactcaaa taattcttcc aatcaaaatt attcatatag taatacattg
    56881 atttttgaat taaacctggt gttgatatat ctgatgaata tttagcccat aaaacttttt
    56941 ttaacaactc atttggcatt tctacaattc ctatcctaag acctggcata agtatttttg
    57001 aaaagctttt tatatatact actctatttt tatcatcata acttctaatt gttctattgt
    57061 cctttgattc aaaaacaaaa tcacttataa aatcatcttc tattatataa aaatcatgtt
    57121 cttctgccaa ttctatcaat ttcttttttt tatatgttga gtaagatatt ccagttggat
    57181 tttgaaaatt aggcataatg tatataagtc ttggttttat tttttccaac tttaatttta
    57241 aaatacctat atcaattcca tcatctaaca taggtataga tattattttt gcacctctac
    57301 ttttaaacac ttcaattgct ccattgtaag aaggttcttc cataaaaaca acatctgaat
    57361 aacttataag tcctttacaa actatatcta taccttgttg agcacctgat attatttgaa
    57421 tattttcctt agtagttttt atatttccat cacttagata ctctaccatt ttttctctta
    57481 attcttcaga gccaagacct tcatcatatt caaatattga actaccatct ttagataatg
    57541 ccatatttac agcattttta aatgaatcga taggaaacat atcattagat ggattcccat
    57601 tgtcaaaatg aattaaatct tctctttgca caataatctt atttttcctg ttatctatac
    57661 cgcttttata agaatttaaa cttgatacaa aagtaccact ccctataatt ttatatacat
    57721 atccttcatt ttctaaaagc tcgtatacct taactatagt agtgttattt acttgtaaaa
    57781 aatttgatag ttttcttatt ggaggcaatt tttcatgttc tactaactct ttatttatta
    57841 tcaattcttt tatatgatta aatatctgta tatatttagt tgattttttc tcatttaaat
    57901 ctattctgta tttttccaaa tttatcaccg ctcattgtat ttatatttta ttgatgcttt
    57961 tatgtatatt tgatattatt tagtatgtat atataatacc aaaattttta taaaaagggg
    58021 aaatatttat gttttatgac tatcacatgc actcaagttt ctctacagac ggaaaatcta
    58081 caatggaaca aatggtaaaa aaatctattg aactcggttt ggaggaaatt tgtttcacag
    58141 accatgttga ctatgatgta tatgctgatg attctttttc aattgtctat gaagattatt
    58201 ttaagagttt agagactctt caaagcaaat ataaagataa aatatcaata aaaaaaggaa
    58261 ttgaatttgg agttcaaact caattaatgg atacatacaa aaaggaagca catcaatatc
    58321 cattggactt tataatatgt tctatccatg ctatagatac aatggactta taccttggta
    58381 attattttaa agataaaact caacatgaag tttatgaaaa ttactatctt tatttatata
    58441 atattgttaa gaattataaa gattactctg tcttaggtca tttagattta attaaaaggt
    58501 atgcacctta tgacactgtt ttagatgata gactattttc tgatataatt gaagaaactc
    58561 ttaaacaagc tatttatgat ggcaaaggta tcgagataaa tacctcttgt tatagatata
    58621 atcttccaga cctaacccca tctaagtata tacttcaaat gtataaagac ttgggagggg
    58681 aaatcataac cacaggttca gattcacatc atataagtca agttgcatgt gagtttgact
    58741 acatatattc attactaaaa aatatgggat ttaaatatgt atctaaattt aataaattga
    58801 aaccagaatt tataaaatta taaattttta cacctccttg tgaatatatt taaaagataa
    58861 ggaggtgatt tttttgaaag taccttattt agtactatca acagttattt tatttatatc
    58921 caattttatt gtaagaatat ttggtttttt atataaaata ttcttatcaa gagcactagg
    58981 tgaaacaggt ttaggtatct atcatatgat ttttaacttt ttgatgattt gcttagctgt
    59041 tacaacaaca ggtataccta ctgcacttag ttgtctagtt gcaaagagaa aagctttaaa
    59101 cgatagacac aatactaatg ctttatttat atcaacttta tatatatcat ttttcgtagc
    59161 actaattata tctatagttg catctttcaa tagttctttt ttatcactta aatttttaaa
    59221 agatgctaaa ttaaatctat ttatactagc tgtttgtcct gctatagtta taataactct
    59281 ttcaaacgta ctaagaggat attactatgg cataaagaat gtaaaaatcc ctgctattgg
    59341 acaaatcatt gaacaaattg gtaaaatatt atttgttttt ttacttgtta tgtacataaa
    59401 taataaatct atgaattgtt atatagctct attaggtata tcgattggtg agttgagtaa
    59461 tattatattt atgcttattt gcttatggcg agattcatca tttgacaata ggtatattat
    59521 aagcataaaa gatttttata attcttctat ggaaacatta aaaatgtcta ttcccataac
    59581 ttgtaataga atgtcaaaca tacttttgca atctataagt tctatgatga taccatcaag
    59641 attagcatta tcaggaatga cttatcaaca atctttaagt atgtatggta ttgtcagtgg
    59701 gatggtaatg ccttttatat ttttaccttt tactgttggt tcagcgctta ttgtaaattt
    59761 aataccaact atttcacagg aaatggctct aagaaagcgt aagagtgtaa ttaaaaaaat
    59821 caaatactcc atacttctta ctttatttgt aggcatacta tcatcaatat ttttttattt
    59881 ctttggaaaa gatttatgta tattagtatt taaaaataca cttgcaggag aatatctaaa
    59941 agctatgttt ttagttccac tatttatgtc cctaaatcaa actctatctg gcattttaca
    60001 ttcaataaga aaagaattag cttcaagtat aaatactatt actggcatgt taattcaact
    60061 aatagcttta tatgtatttc ttccaattcc aggacttaat atttatgcat acatatacac
    60121 aatgacgata gtatcaatct ttacttgtct attacatact atagtgcttt ttaaatcact
    60181 aaaatctata cgctagttat aaaaacgtga aggctaccaa tgtaaattat acactttggt
    60241 agccttcctt agatgatttt tatttataat ttaaactgtc tatatatcta cctatctatc
    60301 tgtggcaact tggctttcca cttccatgat taggtccaca ttgcgaaaaa tcacatactt
    60361 tagagaaagt atcaacaagt cttggttgga ttggatttgg tgatgctaaa actactattt
    60421 gttcacttat taatgtgcta actgtttctt gtaagcaaag tactaaatct atatcatttg
    60481 gtataattaa ttcatagaaa ggttcacaac attcgttgca ttctaatttt aatatagatt
    60541 ttcctataca atctacagtt aagttagttt gatattcttg tcttaaagta acagctcttc
    60601 cgtcagctgg caagcatatt ggtgctgaaa gtgtgttaaa agtaaattct acataatcaa
    60661 ctcttctctt acatccacct cctgctctaa ctgctgggaa agctaatgca acgaactctg
    60721 tacatccaca tctacctctt agctctagta ctaaattacg aactgctaca gttaatcctc
    60781 tttgtttata agctactgat ttgccttttc cttgtctaca gcactcagag tttctttctc
    60841 cacaaactgc aaattcaaaa gttgtttcac agtttcttcc tactatatct cctaatgggt
    60901 ctaaatcgaa atcttctaaa gttgtcattc ctgtgtctat aacgattcca tcattactta
    60961 agcatatttt ttctatagtt acacttgctt gacctgcact tggaactgaa ccaaatactt
    61021 ctactacttc tgtttcaaaa gttaatggct ctccatttgg tcctgttgca tctgtaaatg
    61081 tttggaattg catagtatca aatattctat tagcctctat tgcaaatggc actgcatttg
    61141 atacagagaa gtttcttgga gatataggat tacagcattc tggtccacat ttgttttcaa
    61201 aacattcatc tgaatccatt tcacatggtt cacaatcaca tttacaattg tcatggcatc
    61261 cacaattgtc atcacatgga ttaggtttgc atggattgca tgggttaggt ttacatggat
    61321 tacatgggtt gcatggattg caatcatcat ggcactcaca cttattatca gtattacatc
    61381 cattatgatg gtgtgatttt ttaaaacctc tcatgtcttc tgaatttatt tcatctgtat
    61441 acacttcttc ttcattcatt gtagacattg gctgattcat cattcttctt ttattttttt
    61501 tataatcttg catttttcat tgccctccct gtaagcgatt cttattaagt ctttggcttt
    61561 ttgaagccta attaatacta tgcttttata atcttaattg ttacttgctt tttgaattta
    61621 tcaataatta ggcgtattta gtagaaaaat gcatattaat aaaaaaagta ctactatttg
    61681 aaatagtagc actttttttg tcccgaaaca ccggtggcta agtaaattca caccctaggc
    61741 actcccaggt gggtgacttg ccagtaacct ttaacgtcca aactaactag gcatgttata
    61801 atttaccaga cacggtctcc cgtatttcat ttgtaggttg aatttaaaaa agccttatcg
    61861 tatgtttcag gatttcatat tattattata taataaattt tgaatttttt aaagtggttt
    61921 tatatagtaa ttgagataat cttattctat cattactttt tcttcctttt ttctttatgt
    61981 atttagttaa ttatcgtttt ttcttagctc tagttttagt atttttttca ttataattgt
    62041 attcggattc ttgctcatta atgttgtata gttcctcatc gtacactata tcttcatcat
    62101 tttctatatt ttcatagcct gtgttcttat cttctactaa ttcatcttca ttatcctcca
    62161 tttcaccttc atctgttaac tcatcatcat ccaattcttt gtcttcacaa tctaattctt
    62221 cgtcttcata atttaactca tcattattgt cttcatcatc attattacta tcatcacctc
    62281 ttaaaagact tcctaacaat ttgagattat tcatactacc aagattgttt atatttgcca
    62341 aagagctcaa actaaatcca ccttcaccaa agtcatctgg taaaaataat tctgcaaata
    62401 aatctatctt ctttttcatt cctatagctt tttcaactga attttttctt ttttctggga
    62461 atacatctat aatttccttt atcatcatat tctttttatc atcactatcc atttttctga
    62521 aaaaatccgt ttcatcttct gtatctacca tatctatatt atttaatttt tttattcctc
    62581 taactaaatc taaaacactt tctattttta ttagtatttt tctttcatct cttgacatgt
    62641 attttttagt tcttgttatt atttccattc ccatttctaa atcttcttca cttaaatcca
    62701 tgagccttaa acctcttttt atatcatttg catcaaacct taaattgcca tgtgtagact
    62761 gtgaaagttt atcatttgca ttttttttgt tttttctaac tctattattt ccttttgatt
    62821 tatttttatc atcaaatata gagatattac cattactcaa tgcaatcact ccaatcaaaa
    62881 atagtaagtt attcaagaca attccccctt atattatata attgccctat attaaagtat
    62941 gtttttcata ttttaatgtt ccatttttaa agctcagtgc atatatatta tctataagaa
    63001 tttttattta tattatatat cactcacaat tcaccacttc aatattattt ctatatataa
    63061 atagtatgaa tataattcaa tatatattta tagaaagggg tttttttatg aaaaaattag
    63121 atacagagtc attagaaaaa atggctaaac aaaaaaatat tgacaaggat aaaatagaaa
    63181 agatggctga tagttacaaa ggaaaatcag aaaatgaact tatggaggaa cttataaaaa
    63241 taggtaagaa tctagatggc agagatgaag tagtatcaaa attcaaagca tttttagatg
    63301 aaaatcaacg caaaaaactg gataatataa tggaaaaaat ctcagatgca gaaaaccaaa
    63361 gagatactaa accagctaaa actaagaagg ctaaacctac taaaggtaag tcaaattcac
    63421 ctgcaccaaa aaatacacca ggtagtcaac aaaaaaaatc taaaagttta tttaagaaaa
    63481 ctaaaaagtc taaccctcat gaatagataa aaataaacta tttaagtaat tagataatta
    63541 tttttagtta atctattatt aaatttgata ttattgacat aaaaaatcag gtagtgcctt
    63601 aggcactacc tgattgattt taatagtttt atttttttct ttctgtaaca ctttctctat
    63661 caacaattct ataaggtaat tctattttct tattttcaat taattcctta tttattaatt
    63721 ttataaccat tcttattgct actgctccca tatcgtatag aggttgatat actgtagtaa
    63781 gtttaggtct atacattcta gctatcttaa catcattaaa tcctgcaaca gatatgtctt
    63841 ctggaacctt atatccagca tcacatatag catttatagc acctatggca gcctcatcac
    63901 ctgttacaaa agccgcatga ggtattattc catcatctaa tagttctttc atactattgt
    63961 atccactctc ataatcagtt ccaccatact taatcaaact cttgtctaat tctatattgt
    64021 tatttgaaag tgctttctca taaccagcaa gtctttccat ttctaaaaca gtatcatctt
    64081 tactcgtcat tataaaagct atcttttcat gacctttctt tataagatgc tctgtcatat
    64141 caaaagtagc ttcttcgttg ctagtactta ctgtatatat atcataattt ctagcagttt
    64201 tacttatata tgtcgctggt attccacaat tttgtatata gttgatatgt tcttgttcaa
    64261 ctatccatga aatcataact ataccttcca cttgttttgc tctcaataga tttatactct
    64321 taagttcttg ttccttatca gagtatgtat tcgctaaaag aatatcatag tcatacattt
    64381 tagcaacctc ttctatccca tttaacacct cattaacaaa agaatctgaa acttctggaa
    64441 ctattacccc tattaattga ctcttctttg ttactaagct tctagcaagt ggatttggta
    64501 tatatccagt ctcttttata acctctaaaa ctttttgttt gacttcatca gttacaggtt
    64561 ttgaatcatt tataactcta gatacagtag atattgacac tcctgcttgt ttagcaacat
    64621 cttttatcgt tatattgcct ttcatcttca tcctccttat tttactaaat ttatctaaaa
    64681 ctgaaccaaa tttttgaagg ttcctatttt aactacattt atataagttt ttattttacc
    64741 ataaaagcaa gtacatttaa atacattata ttttatatta taccctatat tcaacaaatt
    64801 taataatatt cattcttaat ttaaatcata ttaaaaaata aaataaaaaa atgctggtat
    64861 aaaataccag cattttttta ttctaatgat ttaagtatta gcagccgcaa cctacttcac
    64921 catcaaagaa tccaccacat gaacaagtta ttagcaataa tattaagaaa ggtatccatg
    64981 acattatgtc aatgtctctc cagcaatctt caaaagctaa gaataggaag aatagtacta
    65041 ttatccacca tcctcctcct ccaaagcatc cttcttctcc aaaaaatcta tctaacataa
    65101 caaagccctc ctttttttaa taactgtgtt cttattctaa gcatccacca cagcagcaaa
    65161 gtattaataa aactattagg aatggtatcc atgccattat gtcaaattct gcccagctat
    65221 ctccaaaagc taagaatagg aagaatagta ctattatcca ccatcctcct ccaccaaaac
    65281 atccttcttc tccaaagaat ctatctaaca ttatacgtta cctcctgttg atattttgtt
    65341 gagcttttcg ctcctaacat atactatgca tttggtttcc attttgctaa tgtattttta
    65401 ctattttttt aaatttttta atttgaacta aaaaaggtaa aaccataact tgtataagtt
    65461 actggtttta cctatttaat aatcaatatt ttttagcaac aacaaccatc atcgaagtta
    65521 aataataaca atactattaa tataacccat atccatatat tgtcatcgca taataagtct
    65581 tctaaaatgt ctgtgcataa tagtaagaat actataacta ttattatcaa cattttattc
    65641 ccaaaaaatc cttcgcatcc tccaaagaaa cgttccatat tgtcttctaa ttttgtcata
    65701 actaatcctc cttgaatcat taagagacta agttttgtct ctttaattaa atatatgtag
    65761 taatagacag ataagttact tctaaaaagt ttttattgat tagtttattt atttcttttt
    65821 caccaagttt attgtatcta tcaacttcat ccagataatc ttttttctcc tctgatatag
    65881 tatagattaa actttctatt gattttattt tgtactcctt atatctttct atcaagaagg
    65941 atgtttttga attttctatt cctttcttta catgcattaa ccttgatatg tagtcttctt
    66001 tttcattaga tacataactc tccttttcag ctacatcttc aaggattaaa ttggtctcca
    66061 ttacataatc ctctatacgt tgcatatcta aagttattga attataataa aaatttactg
    66121 ctataagtaa aaacattcct actgaagtta gtaatagtcc tacatatttc atagcatttc
    66181 ctcctaagtt atatttgtta tcaataaagt ttattcatca aataatactt tattactaca
    66241 tttataaaat tttattattt tttatagatt ccatattgaa aaattcttga tattatatta
    66301 aactaacatt aaaattaatt aaaactgctt taggaggctt aaaatgtttg agaaaataaa
    66361 agaaataata gcagaacaat taggggtaga caatttagat gagataacta tggaagcatc
    66421 tttaatggac gacttagaag ctgattcatt agatgctgtt gaaattataa tggcccttga
    66481 agatgaattt ggaatagaaa taccagacga ggaagctgag aactttaaat gtattggtga
    66541 tatatgtaaa tatatcgaag aaaacaaata gtatcgtttt gtctacaaat ataaatagtc
    66601 tgtgtaaact tctacataat aaattatatt agagttcgca cagactagat tacatttatt
    66661 tacaatatat aaaatacacg ctcttatatt taatttatat actaagtata taaattactt
    66721 ttcttcataa aacgtaacat tctttattat tatatctata gttccatctt gattttgttt
    66781 tacagtatac ttcattgggt cttcaaaatc agttagattc ccttttatgt caaaaccatt
    66841 atccgttttt atacttcttt ttttaagctt tttctcaacc cattttttat ctatactaaa
    66901 actttcatca agaccttttt cttccatatg ctctttaaag ctatccttta actcgtcatc
    66961 tttaattgaa ttatcaacaa agtcatttat atcaacttca tgtttttcct tcagtgtata
    67021 atttaatata cttcttacat cttcagcttg ctttatatca ttactaagag cattggttat
    67081 ccaattttca gctgtatttt taaatacctt ggtcttgtac ttatcatcat ctattttttt
    67141 agcatttaaa aattctgtta caaacttaga ttctgaccct tctttttcag catccttatc
    67201 taaaagcctt agatgaaact catcatttat accacttaga ctaatcaaag ctccttgctt
    67261 ttgtcttaaa gtctctggga taccaatttc atttgaaacc atttgaatat taaatttatc
    67321 atccacaaat tcaattgaat gagtgtacaa ctttttataa tctaatttca gtattgctac
    67381 actcttttca tctttaatag tgtataaaca aattgccaaa tcacaagatt ctagtgcagc
    67441 attaattttc ataacgtcaa acaagtaaga tgcaatttct ttagaatttt tcaaaaaagt
    67501 actttcatca tatattattt gttcacaaca gtttttaatt aaattgtcat tataatcttt
    67561 aaaaacacct tttcttaaat cctcatcttt tgcaattctt tttatagctt tctggaaaaa
    67621 accatctact tcttgattaa ctttgccttc aaagtcattt aatattggaa catcactatt
    67681 tttgtccaaa acatgtatta taaatttatg tattatcata tatatcaccc cattatctta
    67741 atttcgatat taactctttc atatcctctg gtatatctgc tttaaatttc aatttttctt
    67801 ttgttcttgg ttgttcaaac tctaacttat atgcatgaag tgcttgccta tttattagct
    67861 cttcatctac ataaccatac aactcatcac ctattattcc atgacctata tgagccatat
    67921 gtactcttat ttgatgtgtt ctaccagttt ctaagcttac ttctaataca gttgcatttt
    67981 ctagtctttc tattacttta tagtgagtaa cagatgactg tcctctttca tctattatcc
    68041 tctttattga atcttctgta ggtctataaa ttggctcatc tatagttccc tcattttctt
    68101 ttataattcc atcaactact gttatatact ttttttcaac tttattttca ctcattgctg
    68161 tagacaaagt atgatgtgca taagcatttt ttgctactat aactaaccct gaagtattca
    68221 tatctaacct atttacaaat cttattttta cattttcttt ttgattatct atatagtaac
    68281 taataccatt tgctattgtt ttatcatagt ggctttttgt tgggtgaact accataaacg
    68341 gaggtttatt caccataatt atatcaaaat catcataaat tatctgtaaa tttaaatctt
    68401 gaggttcaaa atttgctttt tcctcgtcta tttttacttc tattaaatca ccactataca
    68461 cctttaaact cggtttttta tatactccat ttactaaaac actcttttcc ctcttcattt
    68521 ttgataatga cctaactgag aaatttagct tgtccaataa aacttctttt aaagtcattt
    68581 cttcttcatt tgtatacgat ataagattat atctttgatt ctctttttta aacaaacttt
    68641 tacctacttt cttttatatc ttcctacttt ttatatcttc aaaatcatga tattatatat
    68701 tttacactat ttttgtttaa tagataataa ttatttttaa ctataaaaac ctgtaagaat
    68761 aacaaatagt tattcttaca ggttaaattc ataattaaat atttaatttg taaatattat
    68821 aatctaaaac tatctcttaa ctattaaagt agttcccatt cctccaccta tacaaagtgt
    68881 agcaagacca gttttagcat ctcttctctt catttcatat aaaagtgtag taagtattct
    68941 tgctcctgag catcctattg gatgtcctat agctattgct ccaccattaa cattaacttt
    69001 gttcatatct atatttaagt ctcttattac agctacagat tgggcagcaa atgcctcatt
    69061 agcttcaact aaatctatat cttcaatagt catattagca gcttctaaag cttttttagt
    69121 tgctggaact ggtccatatc ccattatttt agggtcaaca ccagctgttc cataagaaac
    69181 tatagttgca agaggctcta ttcctagttc ttcagctttt tctttagcca ttactactag
    69241 catagcagca ccatcattta ttcctgatgc attaccagca gtaactgttc catctttttt
    69301 aaatgcaggt cttaacttag caagtttctc cattgtagtg ccaggcttaa tatattcatc
    69361 tttatctact acagtgtcac cttttcttcc ttttataaca acaggaacta tttcttcatc
    69421 aaattttcct tcagcttgag ctttttcagc tttattttga cttgcaagag ctaattcatc
    69481 ttgttcttct ctagttatat tccattgctc tgctatgttt tcagcagtaa tacccatgtg
    69541 atagttatta aatatgtctg ataatccatc ttttatcatt gaatcaacaa aagcagcatc
    69601 acccattctt gcaccatatc tcgcacttgg tactaaataa ggagacatac tcatgttttc
    69661 agctccacca actaacatta tatcagcatc acctaatgct ataagttgag atgccattga
    69721 aacagatctt aatccagaac cacaaactat atttatagtc atagctggtt tttctactgg
    69781 tattcctgct cctaatgcta tttgtcttgc tatattttgt ccaagacctg ctgtaagtac
    69841 tccccctaaa agagattcat ctatcatatc tggagttatg ttagctcttt ttatagcttc
    69901 tttagctgct gttaccccta actctaccgc tgaaactgat ttaaatgctc ctccaaaact
    69961 tcctactgct gttctagctg cactggcaat tactacttct ctcatattca ttacccccat
    70021 taaattagat ttttcatata tccgaaattg ttttttaaac aattttattt aaatttttaa
    70081 ttcccaaatt cttatttatt ataatcatag aatcctatct tagtttttct tcctaattga
    70141 ttagctctaa ccattttagc taaaagtgga tgaggtctat atttagtatc tccaaactca
    70201 gtatataaaa cgttcattat ggctaaaaca acatctaatc cgattaaatc acctaatgct
    70261 agtggtccca ttggatggtt tgctcctaat ttcatagctt catctatttc ttctttactt
    70321 gcaacaccat ctgcatatat accaacagct tcatttatca taggtataag tattctattt
    70381 actacaaatc caggagattc agatacatct actggtactt tattgatact cttagataat
    70441 tcaaatactg tatcaaaagt aacttttgat gttaactgac cacttataac ttcaactaat
    70501 ttcatcatag gaactggatt aaagaaatgc attcctataa ctttatctgg tctcttagta
    70561 gaagaagcta tttctgttat agataatgat gaagtatttg ttgccaagat agtatcttct
    70621 ttacataatt catctagtaa cttgaaaaca tctttcttta tattcatgtc ttctacagat
    70681 gcttctatta ttaaatccat atcttttaaa tcttcatagt tagtagttga actaacatga
    70741 cttaatattt ctgcttttgt agcttcatcc atttttccct tagtaactaa cttagttaaa
    70801 tttttatcta ataaagctaa acatttatct atagcacctt gagttctact ctttaaacat
    70861 acatcatgtc cacaacttgc aaaagtttgt acaataccac ttcccatagt tccactacct
    70921 attacagcta atttcatagt tataacctcc tgttatttta gtatttatat tctgttaact
    70981 agattaaaat actatttaat ctagttaaca gcaaatatat ttttaattag atttttaccc
    71041 ttttataaag ttagcttctc tcttttcaac gaaagctgac attccttctt tttggtcttt
    71101 agttgaaaaa caaagaccaa ataaattaga ttctatatct attccagtat ttatatcagt
    71161 ttgagcacca agttgtattg cttctttaga gtatctaact gcaagctgag catttttagc
    71221 tattatctta gctaatttct caacttcttc tattaaaatg tctggctcaa cgactctatt
    71281 tactagccct attttttcag cttcatcagc ttttataact tgacctgtaa agattaattc
    71341 ttttgctttt gccattccaa ccaatcttgt aagtctttga gttcctccat atcctggagt
    71401 tattccaaga gttacttctg gctgaccaaa tttagcttta gcagatgcaa ttcttatatc
    71461 acatgccatt gcaagttcac atcctccacc taaagcaaat ccgtttacag cagctatcac
    71521 tactttttta ctattttcta tttctccaaa agcttttgct cctaagatac taaaatcttt
    71581 agcagctaca gcatctaaat ctttcatgta tgcaatatct gctccagcta caaatgcctt
    71641 tccttcccct gtcaatatta caacatcaat agtttcatca ttattaatat ctacaaatac
    71701 ttcataaagt tcttctaaag tctttgaatt tattgcatta agggctttag gtctattcat
    71761 tttcactgta catatatttc catctacttc aacagctaca ttctcataaa ctttaacatc
    71821 acttgtactc ataataccct ccccaagaaa ttagttagct aaaacttcac ctttttcttt
    71881 tgcaacactt aactgactga taagttctgg aagcacttta tgaacatctc caactatacc
    71941 aacatcagca tatttaaata ttggagcttc tggattttta tttatagcaa ctataaactc
    72001 agcatcttcc ataccagcta tatgttgtat tgctccagat ataccacatg ctatataaag
    72061 gtctggtctt acagttttac cagtttgacc aacttgtctt gctttatcta accaacctgc
    72121 atctatagtg gcacgagaac cagaaacttc tccacctata atttcagcta attcataaag
    72181 tatgtctaag ttttcttttc cacccattcc acgtccagca gaaactaata tcttagcatc
    72241 ttctatttta acttgttttt tagcttcttt tattacttgt acaacttgaa ctaatttatc
    72301 agcatcatta aattctacct tgaaacggtt aattacagct tctttagttt catcaggttc
    72361 atttttcttc ataacccctg gtctaactgt agacatttga ggtctgaaat ctttacaaac
    72421 tattgttgcc attatatttc caccaaaggc aggtcttgtc attaataata attttgtatc
    72481 ttcagctact gcaagacctg tacagtcagc agtaagacct gtatgtattc tagcagaaac
    72541 tctaggtgct aaatctctac ctattgaagt tgcaccaaat aatacaacta tagggtcagc
    72601 tgcttttatt gcttcataag ctgcttttgt atatggttca gttgtataca ctgctaaagc
    72661 ttcatcatct actactatta cctcatctgc accatagtgt gctaatgtat ctattaaacc
    72721 ttctacctta ctacctaaaa gtaatgcaga aacttttgta tcataatctt ttgctatttc
    72781 tgtagccttt cctagtaatt ctaaagaaac agtttgaatt acattttctc tttgttctat
    72841 tactactaaa acgttaccca ttctttatcc ccccttaaat tatatgatat acttctcttt
    72901 taatttatct atgataattc cagctgatgt tttcgcatct tcattgtata ttgtaccagc
    72961 tggtttaact gattttgtaa atgatttaaa tacactagtt ggagaacctt taagacctaa
    73021 attagaaggg tcaacttcta tatcttttac agtccatgtt tctactacat cattttcgaa
    73081 agcatcatat attcttccaa ctttcatgta tcttggtgtg ttcatatctt taagagttgt
    73141 tataaggcat ggcattttaa cttttaagtc atggcaacaa tcttcaaatt gtctttttac
    73201 tagtacatat tcaccttcag tttttatttc ttcagcatat gttattgatg gaagatttaa
    73261 atgttcagct atttgaggtc caacttgtgc agtatctcca tctatcgcct gtcttccagc
    73321 tattataata tcaaaatcta tattttttaa tgctcctgct aatgctgatg aagttgccca
    73381 agtatcagca cctgcaaatg ctctatctgt taataatata cctctatctg cacccattgc
    73441 taaagcttct tttaaagcca tatctgcttg aggaggtccc attgttataa cagttacatg
    73501 agcacccatt tcttctttta attttatagc ttcttctaaa cctgctttat catcagggtt
    73561 tattatactt ggtactccat ctctaattaa agtacctgta ttaggatcta gtttaacttc
    73621 tgttgtatct ggaacttgtt ttatacaaac gactatattc ataaatcctt cctccatatc
    73681 tattttaata tcgacctatt gtgtatattt taatatttat ctattttaat aattttcctg
    73741 aaataaccat tctttgaact tcactagttc cttcatatat ttcagttatc ttagcatctc
    73801 tcatcattct ttctactgga tagtcacgag tgtatccata tcctccatga agttgtacag
    73861 cttttgtagt aacttccata gctgtttcag ctgcaaataa ttttgccatt gctgcttcta
    73921 ctccataagg ttttcctaag tctttattta tagctgcttg atatacaagg tgtctagccg
    73981 cttgtacctt aacttccata tcagctaatt ggaattgtgt attttggaat tttgataatg
    74041 gtctaccaaa ttgtactctt tcttttacat atttaacagt ttcatcaaga gcaccttgtg
    74101 ctaaacctaa agcttgtgca gctataccaa ttctaccacc atcaagagta gacattgcta
    74161 tcttaaatcc ttgaccttct tttccaagta aattttcttt aggtattctg caatcctcaa
    74221 atattaattc actcgtagct gaacctctta tacccatttt cttttcttta actccaaagc
    74281 taaacccagg agttcctttt tcaactataa atgctgatat tcctttgttc cccttagatt
    74341 tatcagtcat tgccattact acatatatgt caccagctat tgcatttgtt ataaatattt
    74401 ttgagccatt aagtatgtat tcatccccgt ctaaaacagc agttgtttgt tggccagacg
    74461 catctgtacc agcattaggc tcagtaagac caaatgctcc taatttttct ccacttgcta
    74521 gtggtcttaa gaatttttgt ttttgttctt cattaccata ttgatatata ggccatgagc
    74581 caagagatgt atgagctgat aatataactc ctgtagtacc acaaactcta gacaattctt
    74641 caactgccat tatatatcct acagtgtctc caccttctcc accatattct tttggatatg
    74701 gtatacccat cattcctgct tttgccattt tttccactgt ttcataagga aatctttctt
    74761 cttcatcaag ttctgttgct aaaggtttaa cttcattttc agcgaagctt acatatagct
    74821 ctttaagcat ctgatatttt ttagaattta aatccataat agcctcctca gtattttata
    74881 aatattttat tttcatttat taattaaaat ctcggcaaca tctataataa ggtatttgaa
    74941 tatacgtcga gaaatttata accttaatca aactacgctc tatatttata tgtgattata
    75001 ctaaccaatt atgacattaa tttaatcata aattgttaat ttaaaatcaa ctatacttaa
    75061 aaaaaatctc gctttttgga attttgtgaa atttcaagtt agaataagat ttctttcaca
    75121 ctggttacag ataaaataat ttgtttacga tatttatatt agggtatatt aaacattaaa
    75181 tattgtctgt acatctgttt tttagccatg tacagaagat ttttatcgta taaaaattat
    75241 tttaatagag ctaaataatc gtatttttat ctgactattt tttattttta aatatcttac
    75301 atctataata gtatcactca aaggataatt tttcaataat ttctaattat ttttttaaca
    75361 atatttatta cattttttcc acttttttgt cattttttta ttgtttcgaa aaaaaatcag
    75421 aattttttaa ctttattttg gattattagt ttaaattaga ttttcctctt agatttataa
    75481 atatttacac aaaaaaacta cctctgtata gattgtatac agaggtagtt ttttactaat
    75541 tcctactata gtttactata tttttttacc aattcttaca aacatctacc catttttcac
    75601 acttagaaaa cttctccatt tcttcacatg taagttctat tgcagagtta ctactgccac
    75661 atgcaggaaa tactgtatca aatcttttca ttgaatcatc taaatagact tttatagaat
    75721 tttttaaacc aaatggacag actccaccaa tagcatgtcc agtaaactcc aagacttctt
    75781 ctggtgtcaa cattttagcc ttacaattaa attcagcctt atacttctta ttatcaatct
    75841 tagcatcacc agctgtcaca attaaaattg catcatctcc tattttaaat gagagtgtct
    75901 tagctattct tgctggaata accccagctg cttcagctgc aagttccaca gtagcactag
    75961 attgttcaaa ttctaatata ctgtcttcct tgccaaattg tttaaaatac tctcttacat
    76021 tacttattga cattaaatac ccctcctagt ctgaactttt ataaatttca tattattctt
    76081 aattatatct ataattgatt tatttttcaa attattccat aatattagca ttccatgtat
    76141 cattattttt tccaactact agataaagtc cttttgccat tggaatattg acaatatatt
    76201 ctcctttata ctctacactc ataccagatt cattaaagta cctataatca aaatttagtc
    76261 cttttggaat tacaaaatca acataacctt gattatttgg ttttattcca tatttcagag
    76321 ttctttcagt tatagaattt ttttcattaa ataaatctac atttacatat gcagaacact
    76381 tattcattcc ctttttattt tccacacaat tttcaaactt cattttagca ctgtttaatt
    76441 tataactata tttactatta ttgcttattt taaatcttac aatagtacca acatctctac
    76501 ttctcctgct atcaaaatca aaaacaattt cctctaaatg atttatttca taatctttga
    76561 cacttaccat atctctatat actaatttat ttatagctat gaatagtgta aaaatcccca
    76621 aaataaaaaa tgaaactttt ataaacttct tcatttttag tctccttata ttttgtgcta
    76681 ttgtgctata atattaatca aaattttaat aattaaactt attctttttt gaaatcttaa
    76741 tagaaaaata cattgatatt ataaaaatta ttattgttaa aaatgtcata ctatataaat
    76801 ttatatactt agtattagct atatcagtta cataatttga aagatatact cctccaactt
    76861 tactataatt aaaatgcttt acttgatata caatcatact aatcatcttc aaaagacttc
    76921 catatacaaa gtaaattaaa atacttacta taaaaccaca aactttcatt tttccatatc
    76981 caaacttaaa aattaaaggc agtaaaatcg tcaaaattgc taaaaatata tttacagaaa
    77041 aaaatacatc atttaaaacc atatttctaa agaacactag tgatgtcaat ttacttagta
    77101 aggacacaat tattgttaca gaaattatta atcctacacc taataaatat tttgagtaaa
    77161 ctatatcttc tatactaact ggcatactcc ttataaaaat ccttgaatca ttttcataat
    77221 cacactcaaa cgtatttata aatatcaaat aactaacaac aatacttact gtataatatg
    77281 aaattgaatt aaggaaaaaa taaaacacaa aaaatagcaa tatgtacttt aaattacgga
    77341 taccatctga actaatccct attattaaat cttttcttat taaattgaac atcatctcac
    77401 ctcatttaca taataataca ttagttcttc tatagtagga tttttgacct tatgcttatc
    77461 aatttctatc aataggcttt ttactttcaa gctatctcca actttaacaa gtgcctcatt
    77521 ataatattta tactctttca caccaactat gctttcttta attgcttcta actctgcttt
    77581 atttgcccta attatcttat attcttgttc tattaattct ttcttaacag taaaaatctg
    77641 atttcctcta tttataaaaa caagataatc agcaatttta attaaattat cagtattatg
    77701 agtagaaatt attacactac tacttccatt tttcacaaaa tcttgtaaat actgcattat
    77761 ttcagttctt acaattgggt ctataccagc agttggttca tccaaaatca ataacttagc
    77821 attgtgacta agtgcgcttg ataacataag cttttcagat tgacctttag ataaattttc
    77881 aatatgcata ttttcttcta tatcaaactt attaaggtat tcatcaaacc tttctctatc
    77941 aaaattctta taaaataaag aaactatttt tctaaattcc ttaaccttta aatgcggata
    78001 aaattgtaaa gaatcatata caaaaccaat attgttttta aagcttattg gagaattttc
    78061 aatagtttca ttacaaagtt caatttcacc ttcatctgca tcaataatcc ccattataat
    78121 ttttattaaa gtcgtttttc ccgaaccatt tggtcctata atcccaacaa tatccccttc
    78181 ctttaactct aagtttatat tatttaactt gaattttcct aatttttttg tgatattcct
    78241 tatgctaaac acatcttcac ctcttatgca tttttttata cccacctata catattttaa
    78301 cacattcatt acaaaggtca tttataaatt tataaattaa gaattataaa actatgttat
    78361 aatacaaagt atgaagaggt gaatatatga aaagaattat aactataaat acaaaccaat
    78421 taaataagtc ccttgagact aaagaactct taactagaaa acttatcaat gctggctttg
    78481 aagtgtattc agatatttat ccagacacag agcttattat atcaattggt ggtgatggct
    78541 cttttttaag aacagttaga gatttcgatt ttcctgagat tcccataatg ggaataaata
    78601 caggtcatct ggggtttttt cctgatattt taccagataa gattgatagc tttattgaag
    78661 cttatacaaa aaaagattat attattcaag aaatgtcact tcttaatgcg gaagtatata
    78721 ctactactag tggttctaat atgcttgctg taaatgaggt tgttataaga ggagacaagt
    78781 ctaggactat acacctaaat ttaagccttg ataataaaca tatacaaaat tttagtggag
    78841 atggtatgat tatttctact tccacaggtt caacagccta taactattct gctggaggta
    78901 gtattgttga tataaatctt gaacttatgc agattacacc tttacatccg ataaatacca
    78961 atgcatatag gtgctttaca tcaagtataa tatgttcaaa tgaatctgtt ataaagattg
    79021 caccagaata tagatttgaa gattctgtat tgattgtcgt tgatggagtt gagcacagat
    79081 ttagacaaat cgaaaatata aaagttagta tatctgatgc aaaaataaaa ttacttagaa
    79141 tgtcaaacta tgagttttgg catagagtat ctgaaaaatt tttatagact gtacttagga
    79201 ggatttttaa tatgaaaata ggaataatga gtgatactca tggtagctta ctttactttg
    79261 aaaaagcgtt aaatgtatta tctgattgtg atgttttatt acatggtgga gatgtcttat
    79321 atcatggacc tagaaatgat attccagaag gatataatcc taaaaaattt attgagacat
    79381 taaataaatt agaaaacatt gtgattgtaa aagggaactg tgatgcagat gttgaccaga
    79441 tggttataga acatcctatt cagagtcctt atgtcatgag ccaatttggt gaaattagaa
    79501 ttatattgaa tcatggttat atagaatcag aagaagaaat tattgacaaa gcaaagaaaa
    79561 tgggtggtga catattagtt ttaggacata ctcatgtaaa aaaactatac atggatgata
    79621 atttaatagt aataaatcca ggaagtactt ctatcccaaa agatggaagc cattctgtcg
    79681 caattataga tatcataaaa actgatgatg aggatgagct tgaacttgat ataaacttaa
    79741 ttgacatcaa tactggaaat ataataaata tcaatgatta gtaaattttt aataaaaata
    79801 aaataagctt taatttatta aactcataat aaaaacaagt aaaccatttt atttctatct
    79861 caattagaag tttaagtaca ataccttaaa cttctaatta aatagaatct ggtttacttg
    79921 ttttattata tgctatattg aaatataact tagtttactt gcttctatta tatattatat
    79981 tggagtataa cttagtttac ttatttcatt atatattata ctgaaatata acttagttta
    80041 cttattttat tatatatatt gaagtgcaac ttggtttact tgctattatt atatattaat
    80101 tttgatttac acaatattat tgtaaggcta atgcttctgc atatggttta ctatttttac
    80161 ctccaccaac ttgtacaaat ttatcagcct ttactttttt tataaaactt ttctgtgcac
    80221 tacttaaact tccacttgca agtactacag gtgactttgt ttttgatgct aatactccag
    80281 cagcaagccc atcaactaaa tcagcttctc taccacttcc atcttttgca aaatacatat
    80341 tattaacctt acttgatttt ccataaaact tttctaaaac tttcgcatta gtatcttttc
    80401 tatctgtccc tgctagtctt tctgagttta ctaactgtcc ttcaagtttt ttacttatac
    80461 tgtactcccc acctactatg tatgtcttag ttgagttttg tgtaataaaa ttctttgcct
    80521 cacttcttat gctatcctta cctgtatata ttatagctgt attatcactt gcagctgggc
    80581 ttgatattga agttgcatct gccagtccat tatacccatt aaccactgcc acttttgaga
    80641 cacctaaatc accagtatca tctagctgtc tagtaagaag taaagatgtt tcttctctat
    80701 ctgctccacc gattctactg actaatactt ccatatcttc aagagattct tttacacttg
    80761 atgaaatagc tccttcactt ccaattaaaa taacttctgc tggattaagc ctttttattt
    80821 cctctgttac attatatggt atactatttt tatttgtaag cagtattggc gcatccaatt
    80881 tacttgccaa aggagttgaa gccaatgcat ctggcaatga atttgagtta actagaaaca
    80941 ccctttctga accattattc caaccacttt gagatatttt tatcgctgta tcaaatctat
    81001 cttcaccaat aagtttttcc tcctttggag attttctacc ttgaagataa ttgttcatat
    81061 ctacctgtgc attttgattt ttactaatag tgtctgcata tacacaactt ggcaacataa
    81121 tcccaagtga aagtgcaaat gctattattt ttttagattt aattttcaat acaattcccc
    81181 cttttaaatg ttaataccta ttgatattca tactttttat tgatacccta aactaaaaat
    81241 aattatcttt tataaaaata attatctttt ataaaaataa ttacaaaaat agctatacca
    81301 ttttaagtac aacacaagct tataatcagc ttgacttata aagaatgata tagctattat
    81361 aactttaaat gcttaatttt taaatacttt ttaactaaac tctttcagca tatttttcag
    81421 ctattcttac aattagttta gtagctttct ccatagaact aactggtata cactcatttt
    81481 tcccatggaa gtttaatcca ccagtaaata tatttggaca aggtaatcca ttaaaagata
    81541 atcttgctcc atcagtacca cctcttacag gaactaaacg tggttttata cctaattcct
    81601 ccatagcttc tttagctata tcaactataa acataactgg ctcaatcttt tctttcatat
    81661 tgtaataaga gtcttttaaa tccaattcca ctctattatc gtatttctta tttatttttt
    81721 ctatattctc tatcataata gattttctat tttcaaattt ttctttacaa tggtctctaa
    81781 taatataagc catacttaca ttctcgacat ttccacctat agaatttaaa tgccaaaatc
    81841 cttcatatcc ttctgttgtt tctggtcttt catctgctgg gaacatttct gatatttcag
    81901 cagctatatg tatagcattt accattttat ttttagctga acctggatga acatttctac
    81961 catgtatagt aatggttgca tttgcagcat taaaattttc acattcaagt tctccaacta
    82021 ttcctccatc taaagtatat gcatattttg ctccaaattt ttcaacatca aataaatcag
    82081 cacctctacc aatttcttca tctggtgtaa atcctatttt tatatctcca tgcttaattt
    82141 ctggatgatt tattagatac tctattgcag tcactatctc agctatacca gctttatcat
    82201 cagacccaag tagagttgtt ccatcagtga ctattaaatc gtcaccttta aattcttcca
    82261 actctggaga atcctttaca tacgtaataa catttaacgc ttcatttaaa actatgtctt
    82321 ttccatcata attttctatt attcttggtt taatatcttt tccactaaca tcttcaattg
    82381 tatctaaatg tgatatgaat cctatagtat ccacaccatc agtatttcct tttaaagtag
    82441 ccattatata actattttca tctaaactca catcatcaac acccattgtt tttagctctt
    82501 caactatata cttagctaaa actctttgac cttctgaaga tggacagttc tcacactgag
    82561 aattagatgt tgtatcaaat gatacatatt ttaaaaatct ttccactact ttttgtttca
    82621 cgtatatacc ctctttctta ataagattaa tattttttta tttacctgtg aataaaattt
    82681 tatttttaaa aaaatctatc aattattata attaaaaaat atccaccttc ttaagtatat
    82741 catgcataca taccaaaccc aaacaaaaaa ttactccaat tattcctttt acttggattc
    82801 caataaaaat cgctgctagg gtagctaatg gatttagtcc aacatttact gatactagtt
    82861 taggttcaag tatttctcta atcaaagaca aaacaaaaaa tatcacagtc atacttatag
    82921 ctataaaata attttttata aggaaataat aaacaattac tggaagatat attgttatta
    82981 tacctaggaa tggaattaaa tccattaaag ctcctacaaa ccctactatt agaccgtatt
    83041 tcaatccaaa taaagcaaaa cttccccaga ttgcaaaaaa tgttatagcc ataagtattg
    83101 tataggccct tatatatcca acaagtgaaa gccctgcctc tttctttacg ttttttacct
    83161 tctttctaac atcaacagta aacatattat aaaaactatt ttcaatctta tcaaggtctt
    83221 ttgctataaa gtaggtagca ataaacaggg taattataaa tattataata tatggaatag
    83281 aagtagccaa tccaagtata ctagtaagaa gattttttgt aatttgcatt acttcaccac
    83341 tgaatttgtt tactaattgt tctacatcaa aattggctat ttcttgaaat gatttcataa
    83401 agtcatttat tttatttaaa aaatacataa tagtattact tatatcctca ggattagcag
    83461 atatattatt taaaaatccc attaattctt tcattgaatt tattactatt attgtagtaa
    83521 ctgtactgac tatagccact gcaagaaaac ttagaacaag agtagagata cctttattta
    83581 tacgaaactt attttctaac ttttgtgata taggattaat cataagtgct attatagcac
    83641 ctagaaaaaa tggagctatg tatggaaacg ctttgtaaat aaaaataaat aacaatgtat
    83701 atatacaaaa aaagatagtg ttgtttttta atttgtataa aaaattattt tctagtatgc
    83761 tcatcttaaa aatctccttt cttctaattt atatttttat tttgtccatt tcatactagt
    83821 tttatttgaa tacaaaataa aaagaagtgt ataaatataa aagatatctt ttatatttat
    83881 acacttctaa taaatttaag aacattatta cattatgtat atattcttat ttttttaatt
    83941 ctattttttt ctatactttc tatacaaaat cttatattat caacttcaat tacttcattt
    84001 tcttctggca atctgcttag gtgtccaatt ataaaacctc ctatggaatc aaactcctca
    84061 gattccaagt ttacaccaat aagttcatta acatcaccaa ttttagtact tccatctaca
    84121 atatactcat cttcttttat aacttgtatt tcatcctctt cttcatcata ttcatcctct
    84181 atatctccaa caatgacttc tactaaatct tctatagtta aaagtccaga tgttccacca
    84241 tactcatcta caactatagc catctgactt ttttcaagtt tcatctcttc aagaagttgt
    84301 gttatctttt tgaactcata cgtgaaaaaa ggttctctca tataattttt aatatcaaat
    84361 gactctattt cttcatcaga taaaaatata atatctttta tattaagtat tcctacgata
    84421 tcatctatag tttcttcata cacaggcatt ctacttaatt tttcagtttt aaatacctgt
    84481 attatctcat cataactatc ttccatatct atagctacca tatctattct ttgtaccatt
    84541 gcatttttag cttgcatatc tccaaattca aaaacattat ttatgatttc tctctcttcc
    84601 atttcaagga cgccttcttc atgacttaca tttaccatag tttttagctc ttcttcagtt
    84661 atgaatgatt tagctccttt atttgttata ccaaataatt taaatataat atttgtaatt
    84721 atattaaata tccatactat tggtcttaat ataaatataa ttgcttttat aggtttagat
    84781 actaatagag aaaccttttc tgaattattt gctgctattg tttttggagt aatctcacca
    84841 aatattaata ctaatactgt cataacagct gtagcaagtg ccactccttt ttctcccatt
    84901 aatcctataa acaaagatgt tgatatggat gttgctgcta tatttacgac gttatttcca
    84961 accaatatag aacttaaaag cttatttgga ttttctatta atgaacttac taacttagct
    85021 cctttaactc cttcatcttg catatatctg attctgattt tactcaacga cattaaggcc
    85081 gtttcagatg ctgagaaaaa tgcagaccct ataagtaata ctattaaaaa aataatctga
    85141 atcaaattat tgggcgattc caacacttac cacactccta cttacatgtt tttatattaa
    85201 tattaattat aaataacttt aatattagtt tttattatat cacaattaca tattatttgg
    85261 aaatattaga taatatattc aattaacata tattttctaa ctatattcaa tttttacttt
    85321 tgaacctatt ccagcctcac tagatgaaac taatagctta acaggaactc tatttttaag
    85381 ttcctcgaca tgacttatta tacccacact tagattatta ctatgcaatc tttccaagga
    85441 ttctataaca atttctaaaa gttcactatc taatgaacca aaaccttcat ctaaaaagaa
    85501 aaattctaat ggtgcacttc cctttaattg tatttgagat gaaagagcaa gtgctaatga
    85561 tagagatgtc aagaatgtct ctccaccaga tagagtatca atgcttcttc tttctcctcc
    85621 attaaagtta tctctcatta caaagtttag tgttgagtca atttcaagtg catatcttcc
    85681 ttttgttatt ccatccaatc gttttgatgc ttccaatgct atatatttta attggtttgt
    85741 agaaacatat tctacaaatt tatttccttg tacacattta tctaattctt ccaataagtc
    85801 cacattgtgt tcaactacct taagttgttt attaaaatca tttatcttat ctaaagagtc
    85861 ttttaatgtt attaactgat tttgattagc tccaatatct ttggatatat ttcctatttc
    85921 tactttcaaa ttataaattt catcttttaa ctgttcaaag tactccttct ttatgcttct
    85981 tccatttaat ttttcttttg atgattttat tttaaatgat aataactttt gttcttcttc
    86041 atgctctagt atttcttcaa tcaatttttt tactgcatca gtatctaata aagctctttt
    86101 tactgcatat atactttcaa atttattttc tgctaatagt ttatttagtg ttgatttttg
    86161 gtctttatat tgttccttag cagttttaag tctaccatct atattgtgct tttcagcaat
    86221 gtttttttca tattctaatc tttgctcttc caattttttc ttacttgatt cttcttgttc
    86281 taatatctta catatatttt cttcaacatt atgtaaaaga tttttagcta aatcaccttt
    86341 cgttatgcta ataacttctt tatacttatt atccctactc aatttctttt ctacatataa
    86401 ttctctagcc tttattaatt ctatctctat ttcatgtagt ttactctcat tttctcttat
    86461 tttaatatct agtgagtctc tattttttaa taaatttgaa tgcccagtac ttagtaattc
    86521 taattctttt tcattctctc ttatttcttt tacttttgac aatagattag agactttagt
    86581 aatcgtcttt aatcctaggt attcctgttt aattttttta catttatttt ctaaaccttc
    86641 tatttctatg tttaaatctc ttgttaattt cttataatta ttcagactct ctcttatttt
    86701 taattcttct ttttcaattt tatttttttc ttctttagct aatgttactt tattttcagt
    86761 actctctttt tctttctccc actcctgaat attagatttt aacaatgcaa gttttctttg
    86821 ttcttcatca agttttttta ataattgact agatggaatc ccccctagtt ttccttttac
    86881 atcttcaagt tctttagtct tcattttttc tatagataaa tacccactta ctttagcatt
    86941 taattcctct atattgtttc ttatacttat tttttctttt tctaatttct ccagtttttc
    87001 tttgacaaaa gatatatttt catcatactt agttatatca tgattttcat gatgttttga
    87061 cccacaaact ggacaaggca tattttcttt taattcacgt ctaagttcag aggctaaatt
    87121 taaatacttt agttcttcca attctttttc taagtcatct ctgttctttc tattattttc
    87181 aagtttttca tttagtaaat ttacttccct ttcagtatta aacttacttt caagtattat
    87241 ctttaattca tcttgtatac tgcttttctt aatttcattt tctttagtat tatttgcttt
    87301 atttcttaat tcagtaacat attcagattt taaaagtaaa tcagcactct taccaggaca
    87361 ttttttaaga agaacatcca agtgaagtga taaattttct aaattacgat ttacatcatt
    87421 cttatcttta tcaatatatc taacttttaa atttatattt tctgtctctt tgagtatttc
    87481 ttctagttta tttagctttt gatttttttc ttccaatacg ttgttgtaat ctttctcgta
    87541 ttcatatgct agaaatattt tttgttttaa ttctgcactt atatttactt tatcaatctt
    87601 tccttcaact tcttttatag atttagtaac tgcatctttt ctggactctg acacctgctt
    87661 tactttttct aattcaactt tagtcttatt taaattaatt ccactttctt ttagctcttt
    87721 taactctcta tctaataaaa ctaactcttc ttctaatttt attgcttgtt gcaatcttat
    87781 tttttcttca ctcaatttag ggacttcttc attcttaatt ttgtttattt tttcatatct
    87841 attttttgta acttcaagct cctgatttaa tattgctaat ttcttttcta aattacttac
    87901 tgcaaaacta tcttcatcta gctttttttc tagattttga actgaactta tgtatgggtc
    87961 taccttttta gcgttactat cattttctac aagagcaatc ttttctttta tctcactatt
    88021 ttttaaatca agctcatttt ttctaagttc atttttttct aactttaatt gttcttcata
    88081 tactgtttta ctttcttcat aagatttttg agctaggtct aaagcattat tcttatcttt
    88141 ttccaaattt tttaactcta ttaattcttg gtttattttg ttgtatactt cctctgtaat
    88201 tccatcatat tgacttaatt ttgatttcaa atcttttaaa ttttgtaact gtatattttt
    88261 tctctttttc actttttctc caagacttct tccatatttc tcaagattaa aaattctctc
    88321 taacatgtct cttctatctg cacgtgataa tcttagaaac tcattaaatt tgtcttgtgg
    88381 taaaactact gacctagtaa aatcatttgc cgttaatcct acaacctgtg ctactttttc
    88441 atttacttcc acaactttat cagctaaaac attttgggta ttgtcattca atacttctat
    88501 taatctagca ttagaggtct ttgttcctgt tttgcttcta gcaatggttc tatctacaat
    88561 gtatcttctt ctagtgtttt tgcttcctat ctcaaactcg tatgatataa ttgccttatc
    88621 gcacacactg tttatatatt cttttgtatt tctggatata tttccataca tagcaatagt
    88681 tattgcatct aagattgtag attttccact tccagtagtt ccaaatatcc caaacaaacc
    88741 tctttcaatt aatttttcaa agtctataac ttgtttatca atatagctat taagccctgt
    88801 aagttctaat ctaattggtc tcatctgctg attcaccttc ttcacttatt atatctagaa
    88861 ataaatccat aagttctcct tttggctcta cacctttact aaaagaatag aactctctaa
    88921 acaactctgc catagacttt tcttttatat ctacactttc ttgttcataa caagatgtta
    88981 ttattggttt tatttctatt atgtctttta atagttcctt cattttttta atttcattct
    89041 gtgatattat ctcatcagta tttatttcaa aatatgacca aatctctcta tcttgatttt
    89101 gctcacatat atctagtgct tcttctattc cattacattt aaatacttct ataggtttgt
    89161 aattattaaa atatacatct tcaattattg gtttttcacc agcttttata tccactatgt
    89221 atgccccttt ggtatacgct ctttcatcct tgctatattg aagtggagaa ccagaatagt
    89281 atgcatttaa acgttcggaa gctttttgtt gtttatgtaa atgacctagt gcagtatatt
    89341 gagccttttc tggcaaatct tttctttcaa ctaaaaaact tccacctaac tgtataggtc
    89401 tttctgattc agtactctct ccacctatta caaatatatg tgatacggct atatttatag
    89461 tatcacttct aaaattttct tctaaacttc taaatatatc tcctaccttt tcagaataat
    89521 ttttttgttt ctcaaactca tcttcacttg aaaaaacttc atttaatctt ttttcacttg
    89581 gataaggtaa tgtagcaacc acaatatttt ctccatttat attcagtttt gtacatccct
    89641 gagttgcata tgttatttca aaccctttat acttagcttc tatcgtagca cttaatggat
    89701 aaccatatat aagtatcccc tgttcatgtg ctagaggtgt tattgcagag agtctctctg
    89761 gattatcatg atttcctgaa attattaata cacacctctg accattattg gcaagtcttg
    89821 atacagtctg ataaaatagt ttttctgctt gtgctggtgg attagaagta tcatatacat
    89881 ctccagcaat tataaccata tctatttcat ttgattctac tatttttata aattcctcac
    89941 aaaactttgc ttgttcctca attctagaat ggccttctag ggacttccct agatgccaat
    90001 ctgatgtatg aataaatctc attttttccc cttcctctat cttttaggtt taatttatat
    90061 ataaaaacta ataacaaaca gcttcatcaa ctccaaataa atatatacat ttctctttta
    90121 ctgacttacc agttaaagtt tcaataatat ctgcatataa atccaactgt tttttatatt
    90181 tctctattat ttgatttata ttttcctcat ttacaaaatc tgttttataa tccaccaaaa
    90241 ctatttgatt atcttcttca aaataagcat caactatacc tcttaacatg acactttcat
    90301 tatcataaag ttttttatcg tcattgttta taagcttttc ataaatatat atgtctttca
    90361 tatttacttg tgcataaatt gatttttctc tatttataat ttcagcattc aacattcttt
    90421 ttcctatgtt agaggcaaaa aatttatata ttttatatgg atttactata ctagcttgtt
    90481 tttctgttat tatacctttt gaaacaaaac ctcttatttg tgattttata tcatttacac
    90541 tacttacatt ttttaagtct aaaacctcca taactaaatg gactattgta cctctttctg
    90601 ttccacttat tttttctctt tcttcttcat tttgaataaa tagaggcttt tttaatatta
    90661 ctttttgttc aaatatagta tttattaact cttcttcata attattttgt atctttttta
    90721 tttctgtaac agatatagta gcaggttttc ttgtactaaa ttcatatgga tatatatagt
    90781 ttaatttttc ttctatttca ctgtaataat cactgtcagg attatctaca tctatttttt
    90841 caagaatttc ttcaatactt tctttttctt catcactctt cttttccact aaaatatcat
    90901 tcttattcca caactttcca taccattttg aattatgttc aacattaaaa actgcgtcta
    90961 atcctacttc ttctagtaga ttagataaat ccctatgtct taatacacaa ggcattatcc
    91021 aatctaaaaa atttttacct tttaatatct cgtattgtga tattgtatct aaactttcaa
    91081 ttccatttga ccatctcttt atactatctt gtatatttct agtagaacca gttataatca
    91141 atttttcttt agctcttgta aatgcaacat ataaaactct catctcttct gataaatttt
    91201 ctatatttat tttgcttttt aatgcttctt tggctatact tggaaaagaa atccttctct
    91261 catagtctac aaattgaggt ccatacccta aattatgatg atataaaata ctctttttaa
    91321 aatcttgagt attgaaattt ttacccattg cagagcatat gactactgga aattctagac
    91381 ctttactttt atgaatactc attattctaa caacatttgc attctcacca agtgtttttg
    91441 cacttcccat atcagaacta gattttttta atttctctat aaaatttaca aagttgaata
    91501 ttcctttaag actggtttct tcaaattgtt ttgctctctc aaacaatact tttaaattag
    91561 cttgtctttg acttccacct ggcaatgctc caacataggc atagtatcca gtccttgtgt
    91621 acaagtacca tataaattca tctgtactca tgtacattga cttttcttta aattccttta
    91681 gcttaattaa aaaatcttta cttttgttta tgcactcttc acttggtata aactcagact
    91741 cattttcatt ttgagaatct gtaaatccat catactctgc tgtacttttt aaaacctcat
    91801 aaaaaatttt atctttactc tgaactctaa tatcaatcaa atcctctggt gtaaatccaa
    91861 atataggtga ttttaataca gatataagag gtatatcttg cattggatta tctattattt
    91921 gaagtaatga caatattgtt tttatttcaa tcgtatcaaa ataccccact ccaacatcag
    91981 catacgttgg tatatccata ttcatcaatt catctgcaaa cactggagcc catgcagatg
    92041 tagctcttaa aagaataact atatctctaa attccacagg tctatatcca tctattccct
    92101 tatcatagac cttttgaatt tttccatctt cattgacttt cattaaatct ttgataatgt
    92161 ttccaaccat tctagcctca agttgtatat tatctaaatt ttcttcttcc tctatttcat
    92221 tttctttgtt attaattcta tcgtctttat catttataat atcatcatca agtttattat
    92281 ctttttgtat taggtgtatc tccgttgctc caccaataat agatttctcg tctgtatcca
    92341 cattaaaatt tgcacctaaa tttagtcttt ctttttctgt atattcaatt tctcctatat
    92401 tctcattcat tatattttca aatatataat ttacagcatc tacaacttct tctctacttc
    92461 taaaattttt gtaaagcatt atttttctat gggaacttcc ctttttatca ttatagttat
    92521 tatatttttg caaaaataat tctggctttg cttgtctaaa tctatatata ctctgtttta
    92581 catcaccaac cataaatcta tttggagttt ctgtatttgc aacagcttta agcagtactt
    92641 cctgcactag attactatcc tgatattcat ctataaatat ttcataaaac ttgtttctat
    92701 atccaactgc tatatcagaa ggtacaatat tacctttttc atctacatct gtaagtatat
    92761 ttaatgcaaa atgctctata tcgttaaaat ctattattcc tttttctctt ttcttattgc
    92821 tatattcctc ttcaaatctc agtacaacac tagatattgg tttaactatg ttataaagat
    92881 attttatttc ttctctaata gaatcattat ctttattgaa tgtagcactt actatacttt
    92941 ctaaagactt cttagtctta tctcttatag tttttgcctt ttcttttgat tcttttatat
    93001 acgaaggagc atcttttgaa attcttttta ctccttttac ataattttca aaggacatac
    93061 ttgccatctt tttatatgcc tcatcccaag atttattaca tgcttgtgaa atgtcagcaa
    93121 tttttttata ttcaacagat aacttttctg caaaagtttc taattcttct attgattcca
    93181 cttcttttaa tgccctttcc atatttagac aaagaccatt aatctctatt tttacagtgt
    93241 ctaatatagc tctagcccaa atagactgtg aaaaatcaaa attttcatca atattaaatc
    93301 gttctgctga gtcaatcaac cattttttag gttcaggaga agccattgca aatgaatata
    93361 ttcccaagat aatatcttgt acttctttat ctcctcctct ttctgcataa ctttcaacta
    93421 aatttaaaaa cccctcatct ctttcttcat ataaatcttc aaatacttcc tctattgctt
    93481 cttgtttcaa aatagcacat tcagtttggt ctcctattct gaaattaggg tctaagttta
    93541 ttctatgaaa gtttgatttt ataacatcca aacagaatga gtgtattgtt gtaatactag
    93601 atttatttaa taaaacaagt tggttttgta aatgtttatt ttctgggttt tcatctaagg
    93661 cttttcctat agcatcccct atcctctctc tcatttctga cgcagcagca ttagtaaatg
    93721 taacaactaa taacttatct atatcaattg gattttctct acttgttatc atttgaatta
    93781 tacgctcaac tagaacggct gtttttcctg aaccagcagc agcagcaacc aataaattgc
    93841 attctctact ttctataact tctaattgct cttttgtcca tttaggagaa ctcactaatt
    93901 aacatctcct ttcatcattt ttattatctc ttcattactc ttattattta aatttttata
    93961 cttgttatct tttatagttg aatcaaactg acatatagca gagtaatcac aaaagtcaca
    94021 tgatgttcca tctttatgtt tatatggagc tatacgtatt tctccactta acatttcttc
    94081 acataaatcc tttatagcat gccttacata ttttctaagc agtttgaaat cctcatagct
    94141 tattgctgaa gtacttttac ctacatttcc atccttagta agacctactg gtattactaa
    94201 agagtttttc ctttctccat ctattaatga tttatccatc tctttaacta tgtgagagtc
    94261 ttttactaca agccccttca ttctaagttc ttttaatatt gcttcttgta tttcttcatc
    94321 atctttatct tcattaaatt ttgctattgg attatttatt ctacaatata gtattgcagc
    94381 tggatttata tttatatctt catcctttgc actttcaagg attgcatcta aatacacaag
    94441 taattgtaat tgtagaccat aatatatttc tgttagactt atggacttat tgcctgactt
    94501 ataatctatt attcttatat atttattttc tccttcttca aattcatcaa ctctatctat
    94561 ttgtccaatt aaacttactt cttgtccatt ttctaacacc atttttatag gtggatattt
    94621 tccattgttg ccaaatttaa cttcataatc tattggttca aatgaacctt gttttatttg
    94681 ctgactaatt atagttatag cagttgtcaa catattcttt aatctatatg caaggtattt
    94741 atacctctca gaactattta atatatatcc tggtatcttt aaaattattt catcaactat
    94801 tatacctatc tttaattcta tatatttttc atcaatatct ctccaagtta aattatcttg
    94861 taaaagttct tttgaaaacc tatctaaaat attatgaata aaagttccta aatctggtgg
    94921 tgtaaatgaa tactctttac gcttttttgc ttttagacca tattgtataa aataagcaaa
    94981 tggacattca gcatattttt caagcctaga tatgctaaga gaattacttt tatacaatga
    95041 ccttattttt ttctcttcaa tcttatgaac ttgattagta taactaagac cttttataac
    95101 tttttttgtt atagaactat agacttcatc ttttaaatag tacctatata tatctaacca
    95161 aatactatta atctcttctg tattgtaacc atcactgtca taatttttta ttatgtttat
    95221 aagttcatta aatgtagggg atttaaccgt tattttttta agtatatctt tatcagtgct
    95281 tttattttct tccactaaat aacttttatt ttctatattt ggaaatatct tcttaagtct
    95341 tgatataatt attgatggtc taagcgtttt accttcatgg tctgatattg gatatgttat
    95401 ggttaaattc ttagatgtcg aagtaagagc tttatataca agaaactgtt cttcaaaact
    95461 cctagtctta ctatcaatat caacttcgat tcctttgttt ccaagacttt ccctatcatt
    95521 atcactcaat attccactat cctttgtaat cagcggaaac acaccatcag tagttccaac
    95581 taggtataaa tatttcgtgt ctggattttt cattctatcc acactactta caagtacctg
    95641 gtctatacta ggaggaacca gtcctaattc atattcatca aaacctaagg ttattaattt
    95701 tataaatttt tctaaagaaa ttatttcatc acccataagt tccaccattt ggtctaatat
    95761 gtccactact atgtcccaaa cttgtgagta ttgatttgca acatcaagtt cccctttatc
    95821 cttaaaattt actattaaac tttctatagt ttctggcata tttatatcta ataaaaattc
    95881 atatatatat ctacagattt cttttactct attttttcct cttaattttt cttgtaaaat
    95941 tactataggc tctaatactc tattttttat ttcatttatt ttctctttta attccagttc
    96001 aaattcactt tcttgacctg aaagactttg agttattcta taatcccatt tttcatcaaa
    96061 ccatttttta cctttaatcc cattagccaa cacataattt tctagtaaat ttatatcatc
    96121 attatcaatt cctataagtc cactttttaa atacctaaac atagtttcat acccatatcg
    96181 tctattcttc atttctaaag ctgaaataat taaaataact attggattac tttttgcctc
    96241 tctcttctta tctataaagt ttggtatatt atattcatta aatatagagt gtactaaaaa
    96301 atcatatcta tttaaatctc ttgtagcaat ggttatatct ctatatctga cattcttatc
    96361 tctaactaaa tgtacaattt ctctggctat ctcttccacc tctgaatata aattgttaaa
    96421 ctcttttatc tttatatttt cagttggatt tgaatatatt ttatatggat aagcattata
    96481 aaatctttct aagtgctgta attccttaac tttttcaaat ctttttataa cacctgtgtt
    96541 taaatttact tgtggcaata tttttatgcc ttcttcgttg cacaattgag tcaattttga
    96601 ataagtaaat ttcgttctag aaaacatatc agatttactg tacccaatat agttgatatc
    96661 atctacagtc aaagagatat taacactttt agacttattt aatatactct ttatgacatt
    96721 gtactgattt ggtgtaaaac ctgtaaattc atctatataa acacaagctc catctaaata
    96781 actgcttaat tcaattttac ttgccaatga agttaacata tcttgagcat ctacataatt
    96841 ttcatgcaat ttcccttcaa aagaattata tattttactt atatctttta attttaaact
    96901 taaagtttca ttatccaatt ctccagatat attttctaac atttcagggc ttatattgta
    96961 ttgtttcatt tctgatatca tatctgtaat tgaacttaca aaaccagact gcgattttga
    97021 ttttgaaaac acatttaatt cttcacttac atcttcaata gctctatata ccatcattgc
    97081 ttttccacta gaatttatat ttacatctgt caatcctcct acttgagaaa aaactatatt
    97141 acttagtgtc ttaaagctaa gtaccctaac tcttagatac ttatcttttt cttttcctaa
    97201 aaatagttta cttactctat tttcagcctc aaatgtgtac tgttctggaa ctaaaagtat
    97261 aattgatgtc gtttcatttt tttgagcttc ttttttaatc tcatctagta tataggtgga
    97321 ttttccactt ccacttctac ctaatacaaa cctaagtccc ataaatttcc gcctccaaaa
    97381 tactataatc tatttctttg ccattacata acttattaaa ttcacaatac ttgcaatgct
    97441 ttttatttct atagcacata cgttcttctt tattatatac cttttctata tcattgtata
    97501 gattgtcttc gtatgtatgt tcttcataat tagtgttttt tatcatactt atataatttt
    97561 gaattttatt tctatttgct tcatgttttt cttcatcata taaaatggta attggtaagt
    97621 catcaaattc aggttgataa tatctcatat ttatatcttt aacatttatg tccattttta
    97681 aaactttagg tattacttct tttgctaaaa acatataaac aatagtttgt attctatttt
    97741 ctacgtgttt atagtcaatc tttttagact cggttttcca atcccatatt tctatattgt
    97801 tatttccaat tacaactaaa tcatactttg cctgtattat atccccattt aatgtcatcc
    97861 ttacttcata ttctggcaaa tacgtttttc ctttttcaat aggaacaact ttttttatat
    97921 tttccatcca ctttaaaaac tttttactat ttttatcatc ctcattaaaa tagattccaa
    97981 gaggtatatt gctaaaatat ctttcacaaa tcaaatgaaa atctcttcct gtttttaaag
    98041 tttcataata ctctctacta ccaacatcat catttttcca atttattcta tcaatatatt
    98101 tatatttaaa tttcaatgga catgatttat atgtgttaat tgaattttga ctataagaaa
    98161 aatattttaa tttatcgttc actcatatca cttctctctt aactttattt tttagtagtt
    98221 acttactgta catattgttt tatccccttt tagatatatt tcaagcaatc ttttaataac
    98281 ttattatata ttaatttgac cttttttcaa taatatgttg attaagtctg cttaaatata
    98341 tacatggttt ttgctctttt ctcttattcc ctatatcact ttcatctcta taagcacttc
    98401 ctgaaagtac taacatttcc tttgctctag taatccctac atataaaagt ctaatctttt
    98461 catttataga atcaatcttc gttttatgag cataatctgt tgaaatactt ccttttaata
    98521 tagcttcaac ttctgattta ataattgcca tagggttttt atatttttct tttagatacc
    98581 atttatcact ctgaaacttt tgattaatat tgtcagggaa attatattca acaagaccta
    98641 gtaaaaacac acaatcccat tccatcccct ttgacttatg atagttacat agtgttatac
    98701 taccgggctc tggttcatat ccatttatct catataccac atctattata tgattaaaca
    98761 ccctgttctt tacatcaaac aataaattat atacatcttc taaatccata tttatatttt
    98821 ctgatactag atactttata taaaaagata tataatccag tacagcttta tcttcttttt
    98881 ctaaattaag ttttttccca ataaacaaaa ctaagaggtc taaccttatt attggatatt
    98941 ctaatatctg ttttataata tctattcctc ttttaaaact taagtatata tcactttctt
    99001 ctttaaattc tattaaatca ttatctaact tactaaattc aaaattataa ataatttctt
    99061 cggtagaata gttttttaat tcttctaaaa aatactttat ttcttcttca ttatcagtat
    99121 ctataaaaac tttattaagt acaactatta acttttctac atcatcacaa tgcaacataa
    99181 aatcaataat atatgctata ttgtttataa ccttcctttt attcaaagaa tttggtccta
    99241 attcttcaaa ggttagatta ttctctctaa gttctttagc aacttgtgtc acttgttcat
    99301 taaatggaac caatatacct atacttttat ctggatattt attttttata cccttaacgt
    99361 atctagcagt ttgctctatt tcaattttcc aactctcata ccactttaca tttatattat
    99421 aatgttctgg attagggttt tctttatatc ccattccatt tggcacagtt tttatttgca
    99481 tatcttcaag agcatgtcta cattctttct gtctaaattc ctttgtaaca tacttgacaa
    99541 gagtgtttgc taaatcaagt atatcttttg aacttcgatt tgacatatcc atcctataac
    99601 agaaatctgc actatttata aattctttaa aaaatttagg gtctgatgat gaaaatgttc
    99661 ctgttatact ctgatttata tctccaactc taactaggtt tttattttcg ctagatataa
    99721 tttttattat attaccttga atttcatttg agtcctggca ctcatcttca aatatatatt
    99781 tgtatctagt ttgaaacttc tttctaagcc cttcgtctaa gcttaaagtt ttttctgcta
    99841 aaattaatat atcatcataa tctagcaatc cattttgctt taattttcta tcatacaatt
    99901 tatatattgg taaaataatt ttaagcattc ctttgtgtcc tcttgacaat atttcttcaa
    99961 gtttatctgg agaaattccc ttatacttaa gttcacttat tgcatttcct gcaaattcaa
   100021 aaaaacctct ttcccaggct tcaagagtta tttctttcca gcgttcatct ttttgctcct
   100081 ttaaaaacca tctaaaagct ctttctccac cttcaaatct aaatctactt atacattcat
   100141 ttaatataat acttttttgc aaatcgtcag ctatgttaaa atcctcactt aacattacaa
   100201 cttctggctt ttcctttatt atttttacag ccaaactgtg tatagtcatt acttcatacg
   100261 aattagtatc atctatttta ttctcttcaa gaatctttct tattctacct ttaaaattat
   100321 ttacagcact attcatatat gtaagaatta atattttacc acccttatgt ttctgctcaa
   100381 gtaatagttt agctactaaa tttgttatta taaatgtttt tccagcacct ggtactgctg
   100441 gtactgccat agtaccatta tcgtaattta ttattggtat ctggtcttct ctataattta
   100501 tattaatcat aatttttatc tcctttatgt gagattttta aaagtatact atataatata
   100561 ctctcttgga tataaccatt aatcgcatat tcacttttaa atgcatagat tttctttgca
   100621 tttaataaca aattatatac tgtattgtat agatagtatt ttttataata ttcttccatt
   100681 tcatttgtat aaatcttttt ttcttcaaaa gattttctaa gtacaattaa attacttata
   100741 tctttttcta ttttcatatt ccaagcatta cttcctatat ctacccatat ttgtatactt
   100801 ctatctatat ttgatgatat atatgaataa ggagtagtta ttactatttt gtctttggat
   100861 ttcaactctt ctatatcgac aacagagtaa taatcgttta ttgtactttt taaagcttct
   100921 ataaatatct tttctttttt catcccaagt agacttaaac tttcactaaa agactcactt
   100981 tcagctatta tctttttaca taacccaaca ttctttttac cttcttttaa atttaacatt
   101041 ttatctatgt aaaattgagt taaaaattca tgtattttta tatcactctt ctttttttct
   101101 tcaatatact gtaaaatctc acgatactga ctatgttcat ctatattatc aatacttaaa
   101161 tgtcttgttt cattaaaaat cttaaatgct tttatcctat ttatttctaa aagagtttct
   101221 aaaaagctta agtattcatc atcttttata aaatctaaat atccataaaa tatacatgta
   101281 gccactacca atgcattccc atatggataa tccacagctt ttttatcctt cttagtacta
   101341 aaaacatcta tatttttttc tatcaaagaa tctctaattt gatgctccaa tatactattg
   101401 tttataggag atataattgc tatatctctt ggagatacat cttcttctat aagagatata
   101461 actttttcac ttattaaatc taacatttca ttatataatt ggcttgattg atttaattct
   101521 atatttgcag gtaataagta taaatcttct attctaatct ccttcttttt aatattttct
   101581 tctttaggct taatttttga tattattttc tcatttatat agtctatatc cacattatta
   101641 aatacagaat aatccctact ataatcaaaa tatatataac tttgtaatgt attatccaat
   101701 gcttctgtta taaaatcaac ttctgcatta cttgagcttt caaggctatc cacaattata
   101761 tatctcactt ctgtaaataa gttttttaaa taaaaatcat cattaagtag gtattgattg
   101821 tataaatata tgcttaatgc attatctaaa attgaatttg atagtaagga atttatataa
   101881 tatgatataa tttcatccat ttgagtgtat gaaaatctat atatactatc tttatttttc
   101941 tttgatgaat atattttttc tccaataaaa tcaaaatcaa ttaaattaaa tgcagactta
   102001 tttatgttag tcattatact atttgctatg gatttattgg ttcctgtaat atcttcaaaa
   102061 tatccttctt gtatcctttt ttccttaact ttttgcacta ttaaatattc acttaaacta
   102121 tttgatataa atgttggaga tacaaccttt gtacttattt catcacattt ttctattatt
   102181 agtggccagt atttaactaa ttctttcttc acaaaactta tatatgttgt tattttcagt
   102241 tcttcactat aatttaatct tagagacctt tcatatcgta tctttgtgtt attgtttggt
   102301 actaacaaaa gaatacacct tgaattatta ccagttttat ctaataattc tctatattta
   102361 tctaaagctt catttccata ttcttttaaa ctactttttt caaataaata ttccatataa
   102421 tcaccttcct caattaaatt aagtgtatat tatctaatta tatcatattg tgtattttac
   102481 aaaacacaat caaattattg catttaacta caaaaaaaga ctgtatatat acttgcattc
   102541 acatgtgcaa atgtacatac agtcttacta ttgatacact tatatttcat tttttgactt
   102601 tagtataaat ttacaactat aaatttacat taagttttta aatattttta tttccattta
   102661 ttttaatgaa tcttctattc ctttacctat ttgtgtaccc atttctttta cttttgcaga
   102721 tgagtttatt aaactcatat cattttcatt atccaaaaat gcacattcta caagtacagc
   102781 tggcatatca ttacttctta aaacgtataa ataatctttt gtagaatcac taggaagtac
   102841 tcttgttttt atacctctat ttgtaagttt aaatttctct aaaattctat ttaatatatt
   102901 ggtagctaca gttttagtaa tccctccatt tttatcttta agcttataaa atacttctac
   102961 accatgacct tgtttattag ttgagccatt ataatgtata cttgtaaata aatctggttt
   103021 caatgaatta gatagagcag ttctatttcc aagagataaa gtcttatctg tgtctcttgt
   103081 cattattaca ttgaatccct ttgaacgtaa atattcagtt gttgcaagtg aagtatttaa
   103141 attgtaatct ttttcaatca ttcctccaga tgaatttcca ggtgctgaac caccatgccc
   103201 tgggtcaatc ataactgtct tgccaccact atttcctggt tctgttggag tcgtattgtg
   103261 tttagataat gatgatgcta tagagctcat taccttagaa gtcaatcctc ctcctatttt
   103321 gtatacctta ttagctgatt tagcttctaa attatcttta tggtatgcag atacata
//
LOCUS       DAEQCW010000002        93288 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.002, whole genome shotgun sequence.
ACCESSION   DAEQCW010000002 DAEQCW010000000
VERSION     DAEQCW010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 93288)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 93288)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..93288
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.002"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(156..2219)
                     /locus_tag="KRO40_000098"
     CDS             complement(156..2219)
                     /locus_tag="KRO40_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF262 domain-containing protein"
                     /protein_id="HBH2090943.1"
                     /translation="MKAGEIEFLSYLEGSNKSFVVPVYQRNYNWKKEQCKRLFDDLED
                     IIDSGFRTHFLGSVVSIYSMGKEYLIIDGQQRVTTVSILLIAMCQIIKEFGESKGIIT
                     TEEQIKECYLINKHSRDKDGKIKLKPIAEDRKAYYELFEEEMNTDRNSNIVSNYLYFY
                     NRIKEDNISIDDLFDAIQKLTIVEIELKNGEDDPQLIFESLNSTGLDLSEADRVRNFV
                     LMGRSSKLQEEFYNNYWYKIEKNTSSNVSSFIRDYLTIKERSIPNKNKVYFSFKRYVS
                     DNGIDIEILLKDLLKFSNYYREISYSCTDDNDVNKVLKRINKLEIFVSYPFILELFDD
                     YNEGIINKKVLVESLNLVECFILRRIVCDVPPNALNKVFMNLGREIKKFSDYKENYSN
                     ILRYIFINKKSSQRFPTDSEFSNAFETKDIYNTKSKNKLYILERLENYNNKEIVDLEN
                     LINNNMLNIEHIMPQTLTNKWKESLGDNYKEIHDKYLHTIGNLTLTGYNSKLSNKTFE
                     EKKEMEDGFKDSRLYLNKYISSIDKWNEEEIKNRTKILLDRAVEIWKYPSVTYEPPSN
                     SENIFTLEDDDVNFTNESIVSFSILGESYKAKNWTEFYEQVALTLYDLDSVRFNSIVD
                     KTYKRDFIDNIKSRDAYKLRKGIKISENIYLETNLNTEAKLNIIRFLLNEFDIELNEV
                     IFSIK"
     gene            complement(2600..5935)
                     /locus_tag="KRO40_000099"
     CDS             complement(2600..5935)
                     /locus_tag="KRO40_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBH2090944.1"
                     /translation="MGNFDFLQKKKNFNSFNTACLEAEKSILVSPSTCATITRRALEL
                     AVKWLYANDSDLVLPYQDNLSTLIHNNSFIELIDYDMLPLLKYIVKLGNLSVHTSANI
                     ERGEAILSLNNLHQFVSWIDYCYSDEYTAEDFNEDLLLHGEEKRTRPDELKNLYERLS
                     SKDKKLEEVIKENEELRKSLTEKRKVNTANYDFKIDEVSEFETRKRYINIELKLAGWE
                     FGKDIWEEIEVQGMPNESGVGYVDYVLYGENGKPLAVVEAKRTSKDPKIGQQQAKLYA
                     DCLEKRYSQRPVIFLTNGFDMYIWDDYSDRKVYGFYKKSELQLMIDRRKSKKSLTSVT
                     INDEISNRYYQKEAIRAVCEALENKQRKTLLVCATGTGKTRIAISIVDVLSRHNWIKN
                     ILFLADRKALVKQAKKSFTKLLPNLALCNLLDSKDSPEDARMIFSTYPTMMNAIDDTK
                     SKDGKRLFTPGHFDLIIIDESHRSIYKKYKSIFDYFDSYLMGLTATPKDEIDKNTYSV
                     FDMENGVPTYAYEYNKAVEDGYLVDYTSIEFKTKIMEDGIKYDELSDEEKEEYENTFN
                     DDESIGDEIGNNAVNEWLFNSDTIDLVLNKLMTEGLKIEGQEKIGKTIIFAKNTKHAR
                     AIVERFNKLYPKYGGNFVKAVDYSINYVDSIIDDFSDKNKLPQIAVSVDMLDTGIDIP
                     EILNLVFFKKVRSKTKFWQMIGRGTRLCPDLLGVDMDKERFLIFDFCNNFEFFKFNPK
                     GFEGNKAETLTEKLFNIKVSMVKELQDIKYIEGEYAELRKELLEELITSVKALNEDSY
                     IVRMNLSYVHKYKNENVWSNIGAVAQNEIREYISPLITSYSDDELAKRFDVVMYNIQL
                     AYLQNNNASKGIRHVMATAEKLSKLGTIPQIQQQKYTIEKAMTEDFWEDSDIFEVEEV
                     RISLRELIKYLEKSSQKIYYTSFEDMIVAEDRNDSVYNANNLKNYKKKVEYYLNSHKD
                     ELAIFKLRNNKKITKQDVETLEEILLKQLGNCDDYKKEFGDTPVSQLVRRLVGLDREA
                     ANEAFSEFLNNKSFNTKQIHFVKLIVDYVVKNGFIEDNKVLMEDPFRTVGSIIDLFEN
                     HIEERNKLIKTINKIKENASEIG"
     gene            complement(5984..6412)
                     /locus_tag="KRO40_000100"
     CDS             complement(5984..6412)
                     /locus_tag="KRO40_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090945.1"
                     /translation="MVIRNKLSWNSIEEVNRDFGSCLYDLQNFKILYDKEEMPELWAR
                     YIKEGFKSYMVSFLELTKAMLYYKSIDLNIKSKNFYDYLLACEYHNLLPKNSSIVIET
                     LRKLRNDDSHGYDIPQFEDMYELFTENEEVFVSIRNSCKK"
     gene            complement(6402..6782)
                     /locus_tag="KRO40_000101"
     CDS             complement(6402..6782)
                     /locus_tag="KRO40_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing
                     protein"
                     /protein_id="HBH2090946.1"
                     /translation="MRNIPNEIKNSIINVFPKENTLAIIIFGSYGTDKHTSESDIDIA
                     WIPIKKVPITELATKTEALRNILDIDVDLKIVTDNYTIALKKAILEGEVIYESKDFKD
                     YINKFYFENSDVIDILDWRDMYGN"
     gene            complement(6815..7123)
                     /locus_tag="KRO40_000102"
     CDS             complement(6815..7123)
                     /locus_tag="KRO40_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090947.1"
                     /translation="MNQIELDLYHNMVNIYKEADLQCNYKPTRFLQLINNKGALLAAK
                     ELINKEGATEGFTRLWECKRLDLSLEVLVLKEKYKELFTDEEREICINRLKDYGYKFN
                     "
     gene            complement(7156..8340)
                     /locus_tag="KRO40_000103"
     CDS             complement(7156..8340)
                     /locus_tag="KRO40_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HBH2090948.1"
                     /translation="MVDEAKILDVVSISGENVKKFDGERSYLSTGNLDFNKISNLEIV
                     TYENKPSRANQTVNIGEVIFAKMKDTKKTLVINKTNKNIIVSTGFYVLKPSKEILPQY
                     LYHYLNSSYFLNQKNRLSKGATQSALNNEGLANIKIRMYNLKVQEKVVRVLDKAQELI
                     DKRKEQIEVLDELVKSRFIEMFGTPSKNEKNWEISEIGKYLDVLTDYHSNGSYETLRD
                     NVTLLDTKGYALMVRTTDLENNNFEKGVKYIDEHAYNYLEKSKVFGGEVIINKIGSAG
                     KVYLMPFLNKPVSLAMNQFMLRFNEDKVNHIFLYNLLLTSYMESKIKEKVRGAVTKTI
                     TKDAVRKINIIVPPIRLQNQFANFVKQVNSLKFEMETSLKELEDNFNSLMQKAFKGEL
                     FN"
     gene            complement(8344..9807)
                     /locus_tag="KRO40_000104"
     CDS             complement(8344..9807)
                     /locus_tag="KRO40_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HBH2090949.1"
                     /translation="MITGELRSKVDKIWETFWTGGLTNPLEVIEQFTYLLFIKGLDEV
                     ETKNEAEATLLGVSFERIFNDEHQHLRWSKFSNEGNSEKMYEIVQNEVFPFIKKLHGN
                     KDSAYAKYMGDAIFKIPTPLMLSKIVDGISNLELSKDRDTKGDLYEYLLSKVATAGTN
                     GQFRTPRHIIDMIVRLIKPTPEDIIVDPAAGSAGFLVSSQQYLRDNHSSLFLVQGLKE
                     HFNNGMFYGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSEVNTDKDKFTLVLANPP
                     FKGSLDYEAVSADLLKVTKTKKTELLFLALFLRVLKIGGRCACIVPDGVLFGSTGGHK
                     SIRKEIVDNHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYS
                     LDDKRNEIKDSDIEDIIKRFDNLDGEVDRKRTEQSFFVDVEEIRENGYDLSINKYKEV
                     VYEEVVYDAPSVIMGRVKALEKEIVDGLEELERMLEV"
     gene            complement(10317..11186)
                     /gene="gatY"
                     /locus_tag="KRO40_000105"
     CDS             complement(10317..11186)
                     /gene="gatY"
                     /locus_tag="KRO40_000105"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBH2090950.1"
                     /translation="MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSP
                     VILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLDHGSSFGLAMQALRVGYTSIM
                     IDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGAYTDPLEAK
                     EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIRDVVSVPLVLHGGSGIPDEVIK
                     ESIKRGICKVNYATELRIAYSNGVKNVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEV
                     CGCVGKAIETVKC"
     gene            complement(11206..13122)
                     /locus_tag="KRO40_000106"
     CDS             complement(11206..13122)
                     /locus_tag="KRO40_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIABC"
                     /protein_id="HBH2090951.1"
                     /translation="MGKKMILGVTGCPTGIAHTFMAEEALKNSARELGCDIKVETNGA
                     IGVENKLTAKDIEMADAIIVACDKNVDMDRFNGKPVIEVPVKEGIHKANELIQRCIDG
                     KVAIRKGNLSSSKIAEEGNLSFGQKLYKDLMNGVSHMLPLVVAGGVLTAISFLWGIYS
                     FDPNSEQYNQIAATLKSVGGYSMNLMVPVLAAFIAQSISGRAGMLAGLVGGMISFDTG
                     SGFLGGIISGFLAGYLVKLFVHLLRKLPRQLEGLKSIFIIPIVSVGLVGVAMLLLGGP
                     CSALNNAMMNFLSGLQNSSPIILGIVIGCMSAFDMGGPVNKAAYVTGTMLLGQGNYLF
                     MAGVSAACITPPLVIAIASTLFKNRFTEEDRAAGLINYILGSTHITEGAIPFAAKNPL
                     KVLPVLMIASSISSILTYIMKIEVPAPHGGFLVLGLVNKPLLWVGCIFVGSLVGAVLY
                     MMVTPKVVNEKNTIENTNATKDEHKNESAESENVSNNISLYSEETVILDVKGKNKTDV
                     IDEMIGILDKSGVLLDKKKFKEEILKREEISSTGFGMGIAIPHAKTDAVKVPRVAVGV
                     SKEGFDFESEDGSLAHIIFMIAATDNGDNLHLKTLSQLSSKLMNEEFLNELLNSKTSR
                     EIVSKLNNEEIKSV"
     gene            complement(13125..14045)
                     /locus_tag="KRO40_000107"
     CDS             complement(13125..14045)
                     /locus_tag="KRO40_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase family hexose kinase"
                     /protein_id="HBH2090952.1"
                     /translation="MIYTLTTNPAIDMNISTNGIKRKLVNRTSNAVYSPNGKGLNVTF
                     VLGHYGIESKILGFFGGFSGKYIVEESEKRGFDVLPTWVEDTTRINIFLNDGSDEFKF
                     VNSGSYVNEKQKLDMLDKIQSLEDISYLSISGSLPPGIDDNYYEDIFKICKNKSIKTI
                     LDISSPKLKELLQYNPYLIKPNDEEIKDIFGIIVRDEEDIKDVLKLLHLKGAQNILLT
                     LGEKGSYFYNGKSIYYASAQPVTVVSSACAGDSALAAFLSIWLENPEHIEEALKRSAA
                     TGASVAESNGIGNLENVEDYIKNIRVRKVV"
     gene            complement(14147..14899)
                     /locus_tag="KRO40_000108"
     CDS             complement(14147..14899)
                     /locus_tag="KRO40_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2090953.1"
                     /translation="MIIELNKSNSENLTKTELEIIKFINENESILPELSIVEIAHETY
                     SSPATVSRAIRKCGLNGFNELRYRLTVKDENDDIQNMGDIINKSFIEAQRVIEQISLT
                     TLINIIKTINKSSKIYILARGLTEYVAKEFSLKLQLLDFNVVFINDPNIMKIKSKSIK
                     KDELIIIFSLNGNTIELVESAQNANLVGAKVITCCCSESAKLIKYSDLYIVGYKHEHI
                     SISEYEVSSRLPLYIISRIIIDYMVRYNNSEN"
     gene            complement(15291..16736)
                     /locus_tag="KRO40_000109"
     CDS             complement(15291..16736)
                     /locus_tag="KRO40_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH2090954.1"
                     /translation="MIKLGKFPKGFLWGGAVAANQLEGAWNEGGKGWCLADVHMYDKD
                     RDISKPYESDMTIERIKFAMKDKNGYYPKCSGIDFYHTYKEDLKLLKALGLKCFRFSI
                     NWARIFPNGDDLEPNEEGLKFYDNLINEVIDNGMEPIVTLLHYETPLNLVLKYKGWSN
                     RKVVDFFVRYAELILNRYKNKVKYWIVINQINLIHYESFNSVAFCVDQVDNVEEARYQ
                     AIHHQFIATALTKKLGKEINSDMMIGMMMADCTSYPEDCDPENVVFALKRNRLQYFFT
                     DVSFRGEYPVYIKRFFKENNINIVMEEGDDKILKENTMDFLALSYYYSTTVSASKNTM
                     NPTDNIKNPYLKANPWGWAIDPKGLYNTLSQYYDRYQKPIMIAENGFGMHDKFEDGKV
                     HDSYRIDYLGKHIEQIGEAIADGTEILAYCMWSPIDIVSCSSQEMEKRYGFIYVDIDN
                     NGNGSKERYKKDSFYWYENVIRTNGEELREK"
     gene            complement(16758..17111)
                     /locus_tag="KRO40_000110"
     CDS             complement(16758..17111)
                     /locus_tag="KRO40_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2090955.1"
                     /translation="MTIEEHIIDEELVEVAMQIILRAGEARTEIKHALNDLEKFDYRN
                     ADLKLAKAKGFMTEAHRAQTKIIQGEAGGEKRAHSLLFAHAQDTLMTIFSELNITMSL
                     VGIVKSIEYKVNNSK"
     gene            complement(17140..18387)
                     /locus_tag="KRO40_000111"
     CDS             complement(17140..18387)
                     /locus_tag="KRO40_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2090956.1"
                     /translation="MGRVFMNKFIDFLSEKFTPVVNNMTKNIWVQSVQSTIMKVLPMV
                     FVGSLVTIVSVLKNYISFLPDLSPINQYTFGLLGLFIAFLLPMEIMKNKKFESMSVVA
                     GLAGAGLMLMMIRPEITNEGAIFNFNRFGGEGMLVSLVAGLFSGLIMSLFGSFSFFGE
                     DSALPDFVSKWFDNMLPITVIMFVGWGLIYGLNFDMFEIIVRVFKPVSDIAQTLPGFV
                     LLNFLVVFIYSLGISGWVLSPITYSIQLGAIAANAAAVASGGVATNIYVYEVIQTGWI
                     TLGGLGATLPLVIMMCLSRVGRIKAIGRACIVPSIMNINEPVIFGAPVAWNPFLMLPM
                     WIGTVVISITTYLSMSMGFVTIPSKVFNLWYVPFGISTFMVNQDVRGLIVLAINIVLL
                     FMIWYPFFKAYEKEEIKLESQEV"
     gene            complement(18395..18712)
                     /locus_tag="KRO40_000112"
     CDS             complement(18395..18712)
                     /locus_tag="KRO40_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2090957.1"
                     /translation="MKNIRVLLACGSGASTGFMATSMRKSAKKKGIEADIKARSESEI
                     DKYLSEIDCLLLGPHLDYMKEEIQQKANEYNVPVACISKTAYGRLDGAKALEEALELI
                     SNK"
     gene            18954..20867
                     /locus_tag="KRO40_000113"
     CDS             18954..20867
                     /locus_tag="KRO40_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2090958.1"
                     /translation="MKTSKKELFLNFIKTQHDWIDSSTLANYLNVSTRSIRKYVNEIN
                     SNGEFILSSKKGYKVNLNNNCQTKVDSSENISPDNRLNLILKELIVNSNGINIFDLSE
                     ELFVSPATIEGDIVKANKFIGSYNLKIKQSKFLLKLIGNESAKRKLMSSIIFKETGSD
                     FLSLFDVQKIYQEYNLTKLKENIIYILKKYNLFINEYAINNILLHLMITIDRIKKNNY
                     IESVEVVNYIDNNNDISISRDISNFLESEYNITLTSAELYYLVFQLTNKTTVLNYHEM
                     DTKSLPNYIDEHFVKLTKKIIKNVYDLYLIDLSDEEFVVKFTLHVKNLISRAKNNQVL
                     RNQIPQKLKDSYPLIYDISVYICNQIQTLENVDIDEDEISYISLHVGSFFDRQKLLED
                     KVLCALITPNYYDLQFKIVRDLEKRFNESIEIIQIFSDTHNLDFDNKVDMVITTLPIN
                     NRCPIPFVYVNPYLNRKDYDNIQSKFTQIKDRKNILTVQNHLEMYFSESLFMKNIYLD
                     SAKDYIKFMGNILYENKYVKPNYIDDVLIREKMSSTAFNNNVAIPHSMKMDALKTGVC
                     LIVNDKPVKWGEEKVQIIAMIPINEKEKEKFNYIFESFIEILSEWNNVKELTKADNYS
                     SFMNRIAYLIQNI"
     gene            complement(20990..22144)
                     /locus_tag="KRO40_000114"
     CDS             complement(20990..22144)
                     /locus_tag="KRO40_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HBH2090959.1"
                     /translation="MKILISIDSLKGSLSSIEAGNAIKKGILKVKEDAQVKILPLADG
                     GEGTVDALVQGMNGKKETIEVTGPIAKKVDATYGLLKNTSTAIIEIAQASGLTLVPTE
                     LRNPLYTTTYGVGEIIKEAINKGYRNFIVGIGGSATNDAGIGMLQALGFEFYDKNNKL
                     VGLGGKVLNEIRHIKIENRLKELDECKFKIACDVNNPLFGKNGAAYIYGSQKGATSEI
                     IEELDNGLRNFSKVVKNYLSKDVANVEGAGAAGGLGFAFLAFLNSKLESGIKIILEEI
                     KLEEELKDADFVITGEGRLDNQTAMGKAPIGVAKLAKKYEVKVIGLAGATTEDAVKCN
                     EEGIDAYFSIVNRAMTIEEAMDKATASENMTATTTQIFNLITSIQQSKNM"
     gene            complement(22423..25038)
                     /gene="mngB"
                     /locus_tag="KRO40_000115"
     CDS             complement(22423..25038)
                     /gene="mngB"
                     /locus_tag="KRO40_000115"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBH2090960.1"
                     /translation="MKKNVHIVPHMHWDREWYFSTEESRILLVNNMEEIMDMLENNHN
                     YPYYVMDGQTAILEDYLAVKPECKERIKKLVQEGRLIIGPWYTQTDEMVVGGESILRN
                     LLYGIKDCDEFGEYMKIGYLPDSFGQSAQMPQILNGFDIKYSMFWRGCSERKGTNKTE
                     FNWKSDDGSSVLVQILPLGYAIGKYLPMNEDELRTRMDKYLPVLDKGATTDHIILPNG
                     HDQMPIQKNIFEVIYKLKECYPERKFFLSRYENIFKELEKNEDIDTIKGEFLDGKYMR
                     VHRSIFSTRMDIKSANARIESKITNILEPLASIAYSLGFEYHHGLIELIWKEIMKNHA
                     HDSIGCCCSDKVHQEIMNRFFLAEEKVDQLITFYKRRIVDAMSCEMALDKLVAFNLMP
                     YDRNEIVSTQVITKMKAFEIFDKDNNKLDFEVVHKEVIDAGLIDRQIVHYGNYDSFMV
                     YTINFKDKIPAMGYKAYMIKEVEHMLEKAYEVCDMVDNDFYTIQVNENGTLKIFDKKL
                     NKTFENVLLMENGGDEGDEYDFSPLPNEKLIFNDNIVANSTIKKNRFNNEIKINYRLK
                     VPKDIQARKNNRADSFIDFDIVINVPNDKAIIDVVFNINNQARDCRVRTYIPTNIASK
                     FSVSDNQFGHIKRSVYDDAMEVWQQEEWSERPDSIYPMLTFVGLSDKEHGVAVLTNST
                     REFEIVGEKFDTIAITLFRSVGFLGKEEMARRPGRPSGIKLPTPDSQMIGDIKIDLAI
                     VTHEKSTLEANVANMAKEYLTKIQTYNKMPYNAMKLNQSEIEVDYSYSLLKETNKDLV
                     LSVVKKAEKEEALVVRFYNSKEETKSANIVFNKNIKTAKWINLNEKELESISIDNNSV
                     NVECLMNQVKTILVK"
     gene            complement(25182..27107)
                     /gene="mngA"
                     /locus_tag="KRO40_000116"
     CDS             complement(25182..27107)
                     /gene="mngA"
                     /locus_tag="KRO40_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS 2-O-a-mannosyl-D-glycerate transporter
                     subunit IIABC"
                     /protein_id="HBH2090961.1"
                     /translation="MEFKKITNENLVFLKQKIKTKEDAIKFLARKLYYEGKLTSYEEY
                     LEAVMYRETLSPTGFERGLAIPHGKSKSVKEASFAAMTLETPIENWESVDPNNKVELI
                     FLIAVPENEGGNTHIQILSELVTRLSNEDYMNMLLNSKTKKELFNNLDIKEKKEQIKE
                     EIRIQNESKKIILAITACPAGIAHTYMSAEALIKAGKEIGVDVYVEKQGANGMVDPHT
                     PDIIKRADAIIYATDVAPKNTERFEHLPNIKTSVAAPLKRAKEIIYEALEVAQKQGKG
                     DYIEKSSDISYCEKSSWKKDVKSAILTGVSHIIPLIVAGGMILAFAVLASQAFGLQEL
                     YNQEGSWLWQLRKLSGGMLGTLMVPVLSAYMSYSLAEKPGLGPGFAAGLAADLIGSGF
                     LGGMLGGLLTGYIVKFLKKNIPAKGTLAGFVSFWVYPVVGSLVVGLLMLFVVGKPVAA
                     LNNGLINWLNGMTGVNAILLGAIIGAMVSFDLGGPINKAAYTFAIGAIASGNFIPYAI
                     FASVKMVSAFGVTIATVLGRDLFSESEKEIGKQTWILGLAGITEGAIPFMIEDPIRVI
                     PSLVAGSAITGSIVAFFNIGLQVPGAGIFSLALLEGSMSGFIIASIWFFAAVLGAIIS
                     AILLIITRKQKNQRKIH"
     gene            complement(27237..27962)
                     /locus_tag="KRO40_000117"
     CDS             complement(27237..27962)
                     /locus_tag="KRO40_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2090962.1"
                     /translation="MEFYERAKKYEYKFTDTEDMIIEYMRKNKEEIVKLSIQSLADKF
                     FTVPNTIVRLCKKMEYDGFSQLKNNLKEELKNEDKEPKNGFESDIKKTLELIDYEKIN
                     KVADIIQKSRSIIVYGIGQNIPLCEILVKEIRGGHDNITYYSQRHEVLHDIGKLGEQD
                     MFFALSLSGETKEVIEAAKTAVNKGCKVVALTHICENQLQQIADISLYCYSTIKQVNG
                     YNISDKVPIMMIMRAIIEQYWLR"
     gene            complement(28225..28995)
                     /locus_tag="KRO40_000118"
     CDS             complement(28225..28995)
                     /locus_tag="KRO40_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ChbG/HpnK family deacetylase"
                     /protein_id="HBH2090963.1"
                     /translation="MKKLVVRADDIGYSEGVTLGIISSYKNGIVTSAGIMVNMPFSRQ
                     AIEMVKNDDVCFGLHVNLVIGEPCCKEHIKIKNLLDEGGKFVSSKIRRTQLLTGKEVF
                     NYEEVYEEVCAQIETYKLYMSKLPEYIDIHGIEEDVSISAMCDAAKEYGIPSCPYYLD
                     SCISMPSKYPQNDFYKLNKSFVKLFEEKYINLDKDITLMVTHPGFIDYSLIKSSSLIQ
                     ERVYEHAMLCDKEVKMWLKRNNIELVDFKDIFKSNNYI"
     gene            complement(28997..30424)
                     /locus_tag="KRO40_000119"
     CDS             complement(28997..30424)
                     /locus_tag="KRO40_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2090964.1"
                     /translation="MMQQLSLLGKTMLVPIAVMPAAGILGLLFGPNMLNVPAISNISN
                     IVFSNVDYLFLLGAASAYSKSKDKTSVMVAAVVAYMIFKSNLELLNDTLNAGVFGGII
                     VGACIAWTYNKTYKVKVPAFLSFFAGEKCVITLSPVVALILSYIFSLLWIYPQAAMNQ
                     FGFWLGGAGAIGIFLFLFCNRALIPTGLHQVLNAYILFEMGEYTTSTGEVIRGEIPRF
                     MAGDPNAGFFWTGFYIIMMFSIPAISYAIYKTAQDKKKQEVKGAMTAGALTSFMATVT
                     EPIEFSFLFASPKLYIIHSFYSGLGGVVLYLLGVRLGSFNGASIIDYVLSFSYGDKAW
                     LVIPVGVVFFVLYYVTFKYIIIKDNVQTPGREVEIEIGDKVSEKEKNLKLSHGNFSYM
                     AKQIIKNCGGYENIVTLNNCMTRLRLEVKDATILNDDNIKKTGAKGVIKLSNTSVQII
                     IGTDVVKVKDEMEMQLDELRKQADA"
     gene            30815..31537
                     /locus_tag="KRO40_000120"
     CDS             30815..31537
                     /locus_tag="KRO40_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2090965.1"
                     /translation="MAKNKFSEIYEVLKEEILDGKYTSNMMLPTELQLIERFSCSRNT
                     VRRAISQLNTEGYVQSIKGKGVVVLENSCSNDFFLNMHNFKGVESIVEDKKVNTATSV
                     LHFSKILIDNKLSKKTGFKVGSEVYYLHRLRYIDNIPKILDINYFLCSIVKDLDVSIA
                     QGSIYKYIEECLGTKIVSSRKIFKIEKATELELKTLPLNDYNCVGVIKNSVYTDDGKL
                     FEYTESKHTPETFVFMDVTQRY"
     gene            31734..33401
                     /locus_tag="KRO40_000121"
     CDS             31734..33401
                     /locus_tag="KRO40_000121"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HBH2090966.1"
                     /translation="MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGV
                     DLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDFEKLLKEAHKRDIKIMMDMVLNH
                     TSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
                     HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGP
                     KGDGRTHYADGPRIHEYLHNMNQKVFKPKNIVTVGEMSSTTPEECINYTRENREELSM
                     VFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGWNALFYSNHDQPRAL
                     SRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAY
                     YHMIKSGIDEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENE
                     LNDSRSVFYTYQRLIKYRKQYDIFTEGTYRLLDENHKNLFVYEREYKNQNLLVISNFT
                     HDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK"
     gene            complement(33497..34816)
                     /locus_tag="KRO40_000122"
     CDS             complement(33497..34816)
                     /locus_tag="KRO40_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2090967.1"
                     /translation="MEKGIKLGFWSIVLLGINAIIGSGIFGLPGDAYTDIGPASILVL
                     VFCMLLAVSIALCFAEAGSWFDTDGGPYLYAKEAFGDFVGFEVGFMKWIVSMIAWATM
                     ANFFAVTLSSVWPQVAEPLIKNIIIGILVVGLGIINFMGMKQSKHLNNIMTIGKLLPI
                     VLFIAVGLFFIKGSNFTPFVIIQKGQSASSAFVAVSITLFYAFTGFESLAVAAKDMEN
                     PKKNVPKALVMVMFVVSVIYMLILGISIGVLGNGLAGSATPVADAAIKMLGPIGGYII
                     TIGTIVSVGGINIASSIFTPRSAAALVEQGLMPKSIRKTNKNGSPYIAIIVSVIGTLL
                     IAWSGSFTTLSQISVVSRFIQYIPTCLAVLILRKKYAGKDVNFRIPGGAIIPIFAVII
                     SILLLIKAGIDEPMKIVWGLGGMIIVVPIYFYMTKVYSKKYNDVEVK"
     gene            complement(34857..35603)
                     /locus_tag="KRO40_000123"
     CDS             complement(34857..35603)
                     /locus_tag="KRO40_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBH2090968.1"
                     /translation="MKKLAKKKYPIIGISGNLLIDEGGMFPGYERAYVNNDYIQSVVM
                     CKAIPYIVPIVYDDEIIKEQVSNIDALILSGGQDVNPLIWKEEPHNKLGAISPKRDSF
                     DMKLLKHALDMKKPVLGICRGEQIINVTEGGSLYQDLSLIEGAYIKHNQQHLSNVPTH
                     TVQIKEGTKLYEILGEKEVLVNSFHHLVVNKVAPGYIVSATSKDGLIEAIEKEGSEFV
                     IGIQWHPEMMTRDYDNMKKIFMAIVKEASK"
     gene            complement(35847..37856)
                     /locus_tag="KRO40_000124"
     CDS             complement(35847..37856)
                     /locus_tag="KRO40_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2090969.1"
                     /translation="MKTIAVVTDGLSKLECFLNKNLEMIFKDKVMIKNYYLNKITEKE
                     LIKDDIILVMIDDRVLKIKKYVEDVSKIITINRSIKQKDIYKLFSLPEGIDVLVVNDN
                     KHTVLETISNLYNIGINHLNFIPYNPNEEYRNIKIAITPGESSLVPKYIEEVIDLGHR
                     YIDSSTFIQIIAKLKLDDKEITERLIKYTDEIISLYSGINTKYKELTIKADELNSIIN
                     LSNLGMAMVSDKGNIIICNNSLRDILDIQSNIIGKNIDELENENIKKIFSLSKAHDEV
                     IKFNNKYLNVNKYNIESFGRVTGYYFCIQEITYIRKLEQNLSKKLREKGQVARYTFDD
                     IKTVSTKMERTKKLGMKIAESDYTILITGESGTGKELMAQSIHNASPRHSQPFIAINC
                     AAMPENLLESELFGYEEGAFTGALKGGKKGLFEQANNGTIFLDEIGDMPIYLQSKLLR
                     VLQENQVMRVGGENVIDIDVRVIAATNKNLLEMIKGDRFRADLYYRINVLPINIPPLR
                     ERKEDIEVMLKHFMKRKRAISQDVQDIINAYEWPGNIRELKNTAMYINIMSSEDVILI
                     NDLPHNLLNITEDFSKEISILKDRTSIEKVKLVMECLKNANNLNKNIGRNGIVNSINE
                     LGYNITEGEVRGILNMLKELDLIICESGRKGSELNRRGKNILNSI"
     gene            complement(38250..39683)
                     /locus_tag="KRO40_000125"
     CDS             complement(38250..39683)
                     /locus_tag="KRO40_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH2090970.1"
                     /translation="MALRKDFLWGGATAANQCEGAWNLDGKGPSCSDMCTGGSQKVSK
                     RITRVIEKGTFYPSHEAIDFYHRYKEDIALFAEMGFKVFRFSIAWTRIFPTGMEKEPN
                     EAGLKFYENVIDECLKYNIEPLITISHYEIPFAITEKYNGWVSRDVIDLYMNYCETIF
                     KRYKGKVKYWLTFNEINSATMPMGGYLSQGILNEGTTDFINQVDIPQLRFQGLHHQFV
                     ASAKAVKLAHEIDSNYQVGCMQIFATMYPYTCNPDDAVKTQRDSRVMNYFCGDVQVRG
                     EYPTYMNRYFGENNIEIKMEKGDLEILKEGCVDFYTFSYYMSTCVSSDSKEDNTSGNI
                     LGGVKNPYLKSSEWGWQIDPEGLRYALNEIYDRYRIPMMVVENGLGAYDKKESNGVIN
                     DDYRIEYLKAHIEQMKEAVEDGVDLFGYTPWGCIDLVSASTGEMAKRYGFIYVDKYDD
                     GSGDLSRIKKKSFDWYKQVIESNGERL"
     gene            complement(39770..41686)
                     /locus_tag="KRO40_000126"
     CDS             complement(39770..41686)
                     /locus_tag="KRO40_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2090971.1"
                     /translation="MRKYEQLSKEIIANVGGKDNISSLSHCITRLRFKLKDESIANDD
                     VLKKMDGIVTVMKSAGQYQVVIGNHVPDVYEVVCDLAGLGGDTIDNSDSDAPKGLLNK
                     FIDIISGVFQPILGVLCAAGMIKGFNAVFTALGLYGETDGAYIMLNAIGDAMFQYMPI
                     ILGYTAAKKFKLKPFIGMLIGAVLCYSGIQLDTLASTGQPLYNLFTGTIFESPVYITF
                     LGLPVIAMNYTSTVVPVILIVLLVAKLEKVFAKIIPDVVKNFFVPMAVLLVSLPLGFM
                     VIGPIATYASNIVGNGFLALFNFSPILCGALTGLLWQVLVIFGLHWGLVPIAMSNLMT
                     MGFDTILVGAFVPSFAQTAVVAAMYFKLKDKKIKELCIPAVISGICGVTEPAIYGITL
                     PRKTPFIYSCVGGAVAGAVMGIMNVKSYVMGGLGIFGIPNYINPTTGDMKGVYATIIA
                     IIVAIVVGFVLTLFFWKDDAIVEISKDDNGQGVIEKNKREVVYSPIKGEVKALEQIQD
                     AAFSTGILGKGVAITPKEGKVVAPFDGTVMTLFPTKHAIGIISDNGCELLIHIGLNTI
                     QLEGKYFKSFVNQGDKIKKGQTLITFDIESISKEGYCLETPVVVTNYSDYVDIVENTQ
                     KHVNNSQKLITVLA"
     gene            complement(41760..42620)
                     /locus_tag="KRO40_000127"
     CDS             complement(41760..42620)
                     /locus_tag="KRO40_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2090972.1"
                     /translation="MIIEKILNNNVIITTDENHKEIVVMGRGLAYKKRTGEHISKDKI
                     DKIFKLSDPNISDKFKELIADIPIRYMELSDEIILYAKEKLGKRLNDSIYISLTDHMY
                     TAIERAREGVSVKNVLLWDIKRFYKSEFKIGLEALDYIEKKFEIRLSEDEAGFIALHI
                     VNAQMDQSIKTIYEITQIIQEISNMVKYHYRIVFDEDSVYYHRFITHLKYFAERIVSN
                     NLHENNEDDLLNVIKVKYKNAYKFIEKLDEFIHKKYNYDLTDEEKLYLTIHVERVVSK
                     SIKSDINPNN"
     gene            complement(42971..44158)
                     /locus_tag="KRO40_000128"
     CDS             complement(42971..44158)
                     /locus_tag="KRO40_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2090973.1"
                     /translation="MIESIKKRAYEIENGLGKEIEEVCNFIFNNPELGEEEYISSKYL
                     VEKMKEYGFDTVYPYCNMETAFRAELGDNDGPTIAFLAEYDALPGYGENKEPAHACGH
                     NWIAASTLGACIVLSKLKENFKGKIVLIGTPAEETTGGKCDLVKAGAFDDVDVSYQMH
                     IEAFNNINCKALAIDSLEFSFEGVSAHAASHPHMGVNALDAVQLTFAGINALRQHVKS
                     DVRIHGIVSNGGEAPNIVPEKAACKFFVRAAERSYLDEVTKKVINCAKGAELMTGAKL
                     SYRYFENSFDNIINNKVLQKITKNNLIEAGITDILEGKDGPVGSTDIGNVSQVCPTMY
                     TEIALDISPMVYVHEKEFLNYANSEEAYDKLHKAVKAMVGCALEIYLEDGLLDEIKKN
                     HLN"
     gene            complement(44172..45563)
                     /locus_tag="KRO40_000129"
     CDS             complement(44172..45563)
                     /locus_tag="KRO40_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HBH2090974.1"
                     /translation="MSSLKKKKFTMPQTLTIIFLLIVLMAILTWIVPSGNFERVDIDG
                     RSVVVAGTYEKAPSNPQGITDVFTAPINGFIDAAEVVGFVLIVGGAFGIVNKTGAIEA
                     VIAHTVNKMKKFQFLIIPISMILFGLGGTTFGMSEETLPFYMIFIPLMTSMGYDSLTA
                     VATVFIGATAGFGAATTNPFSVGIAQALSQIVPGSGIEFRVVMFIIYMAISIGFVMMY
                     ANKVKKDPKKSLVHDISLNQELMVNSDTNIKEFTKREAMVIAIFTIGMAIMIYGVLRL
                     EWYITEIAMIFTAIGIISGIASGLKQDEIVNSFISGAGDLITAGLCIAFARGIVIIAE
                     NGFIIDTILNSAANLLNGLPKTIFINLTFLIEGLIAFLIPSASGLASLTIPVLAPLGD
                     LVDVSRQMIVTAYQFGIGVTNLITPTSGVLMGALAVANIPWSKWVRFVIPLMVVLTIL
                     VMAFLTIGLYLGF"
     gene            complement(46158..47858)
                     /locus_tag="KRO40_000130"
     CDS             complement(46158..47858)
                     /locus_tag="KRO40_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2090975.1"
                     /translation="MHYIAWHFNKNGGNNTMKDKLQVLSGAMMIPVILLVVAGVFIGL
                     GSAFANMENVSALGLSGLIKEGSFINVFFKVINDLGFMVMRYLPIFFVTGIAFGLSKK
                     EKGWGALGGIVLFIGMHTVISTLLAANGINSDTVTAEAFMASGLGEAEAYSRSSLYGS
                     FLGIFSYDCSIFGAIIAGFVASAVHNKFVDIELPSALSFFSGPRFSMIMMFIASIVLG
                     TAMYFIWPPVGLALSKLGNWIGSSGLLGTFTFGAMDKALLPFGIHHLIAFPIEYTRVG
                     GTMEVGGAIYEGVNNIRLAQMGDPDTLSYITRNFTTGRLLIHFAILPAAALAMYKLAD
                     NANKKKAISILIPAIVTAMLVGVTEPIEYTFLFVAPLLYFVAYVPLAGLTYVFTEMFN
                     VSIMGESFRNMFPNLLQPQKVDALPLLFLIPIFFIVTYIIFTWAIKKFDIKTPGRSSE
                     EVKLYSKKEYRERQSVDAGKTAYNNAVEEEVDDKDTKLVHSIIEGLGGSNNIKNVTNC
                     ATRLRVELNSIDGFYEDGFWVNELGASGVVKKKNSVQVIFGPRVITIASKLKAVLGVD
                     "
     gene            complement(47830..49233)
                     /locus_tag="KRO40_000131"
     CDS             complement(47830..49233)
                     /locus_tag="KRO40_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2090976.1"
                     /translation="MIVNKELIIDYLKSNQENIINDIRSLVEIPSIRDESTTDINQPF
                     GIEIRNAFDKLIQIAKDKDFVVKDFDGYAIHIEYGEGEEVVGVLNHIDVVPIYNKELW
                     KSKPFKVCQKDNYLYGRGVNDNKGPLIGILYALLFLRELNEKPKRKIRLIVGGAEETT
                     WECMEHYFSVNEQPKFAFSPDGNFPIVNGEKGILYFNLRKKIDKDKFRNHNLVDIKSN
                     KEDGFVCNKIEAVFKTNDKKDLVESLAYYTEIEELEEGKVLVRYTGERALSRNPHRSY
                     NCAFSLAKDLEKIKKLNDKGVIIRDILNSYFTDDNHGKKLGIYKEDVDMGVSTICIMS
                     IFLEKNELNMKIDFRYPKGISWEFITNRINEIGKKENLIVDIYKDLKLLYVKPDSELI
                     NKLSNAYKQGFGKEAELFTKGAASYARVLKNGVAFGPTIEGDNPNSHQANENISIDTL
                     YKAIEVYIYALYSLAFQ"
     gene            complement(49497..49988)
                     /locus_tag="KRO40_000132"
     CDS             complement(49497..49988)
                     /locus_tag="KRO40_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2090977.1"
                     /translation="MFNIFKKKENKIEKIYSPFKGNLVNLEDVPDAVFAQKMMGDGVA
                     IIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPFDVKVKA
                     GDKVKAKDLIMEVDLDFITSNDLNIITPVVIMDDADSVKRTVKDRIEPGNVDINSIIM
                     EVE"
     gene            complement(50014..50826)
                     /locus_tag="KRO40_000133"
     CDS             complement(50014..50826)
                     /locus_tag="KRO40_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH2090978.1"
                     /translation="MRYKLICTDMDGTLMGKGFEVSEENIKALKEVMEKGIKVALVTG
                     RPYNAMKYFTSVLGDDIYIISTNGTYFKLLGYEYKKVLSKETLKKIYTIGEKYNLNKH
                     FKGCKIVISNNEIGEEHPYRLINSKNKEEDRIEIIENASCETLLEKADNEILKCILFS
                     ENVDSLREAKEEFKKQEDLEVVSSGKINFEVMSKGTSKGIAVKKFCDILGIDSEEVIC
                     IGDNENDISMIKFAGLGIAMGNATDEVKSMADFVTDTNVNDGVAKALRKILS"
     gene            complement(50839..51990)
                     /locus_tag="KRO40_000134"
     CDS             complement(50839..51990)
                     /locus_tag="KRO40_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH2090979.1"
                     /translation="MINFYQPSRINFGQGTLSELPRIIGKYGKKCLLVTTPNVEPLDK
                     LYKRVTLNLIEKGIEVVHFDRVEPNPTVELINEGFELAKKESVDVVLAVGGGSSIDTA
                     KVLALTFGLEKIDWDYMFSTYTNPFKIYDKVSEKELPLIAVSTTSGTGSQVTQAAVIS
                     RGSEKNTIFHQNCFSKECIVDPELMLTLPERITASTAFDAFTHAFESYINPNANDFTE
                     IMSEKSMELVINYLPKVMEDKNNIEYRTKLAVADTLGGSSLANAGAAAPHPLSEIIGG
                     VTHIPHGEALAIVFPKFAEKFYKDNIEKFAKVARMLNQELEKVEDDEAAKTLGNEIES
                     FLKRVGLKTKMSEFNVTKEQLEQITSCPVLGFLPFGKKEDLVEILEKSY"
     gene            52260..52901
                     /locus_tag="KRO40_000135"
     CDS             52260..52901
                     /locus_tag="KRO40_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldolase"
                     /protein_id="HBH2090980.1"
                     /translation="MKYLIDSANLDEIQKCLKYGFKGITANPSMYLKEKVNFHEFIET
                     CANLNPEILTAEVIGNNLYELINSCDKILNINKNTIIKINFSEVGLELINILNSKGVK
                     TACTLIFNVNQASLAINAGADYLFPFIGRNDENGNDGIKNLTEICNLISINGYNTKVV
                     AASIKNVFHLTQASLCGCDYAAVTYDLFKKASFNQLTIDGANTFERDWSKVNK"
     gene            52927..54471
                     /locus_tag="KRO40_000136"
     CDS             52927..54471
                     /locus_tag="KRO40_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2090981.1"
                     /translation="MNKRLLDIAELLLNSSDYITVDTIAEELKVSNKTIRNDLVILDE
                     WLLEFNLSLDKKTGSGVIILGNEDIKLKVIRDINDKSNCIYAYSPEDRKRYILSKLFI
                     KNSKFRIRDICNELHVSRATVHKDLVVIQNFLQNFKVTLVRKTNNGVYLEGKEKDIRK
                     AIFELATVNKSYTELKEILFSKSNECKDTPSTKIFKELFNYDFEKLSQITLHTLQVEK
                     SNLSDEYYINFLIHIAICIKRISIKRYINLSEGFFRELLEHEYFEKSKILCANLSEAF
                     DVEFIDEEVCYILLHIEGLLKSIKKTTTLEPLKNEEITEYNLSEAIAVHWGSILNLNL
                     KDDLILIKSLANHLKSVLHRINYGFTITNPILNDIKRTFPYTYKAAKESNTVIKQLMN
                     YEVNDDEIGYLALYLISAIDRSKSPLNTILICHCSDGVSNLLVQKLSFEFNQINIVKS
                     IPLSSISFTNFDDVDLILTTAPVDFEHNAELININALLSKNDISRLSTIIKKLYSEKN
                     KILSYK"
     gene            complement(54671..55297)
                     /locus_tag="KRO40_000137"
     CDS             complement(54671..55297)
                     /locus_tag="KRO40_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2090982.1"
                     /translation="MKKEMIKDYLLITISAFLMALAVNFFFAEHTLAPGGITGLSVVL
                     STFLSMPVENISLGISMPLLVMGLLFLGKGFGIKTLYITLMGPLFLKVIPQTHITDNL
                     LVAGVIGGLLVGTAIGIAIIRGCSTGGTDLVAMLINKVIKFLKLPVILFMLDGFIIVA
                     SGIISKNFMISIYSLISLLLIIKTIGFVTTKFGKNTEEINNINNACAQ"
     gene            complement(55432..56148)
                     /locus_tag="KRO40_000138"
     CDS             complement(55432..56148)
                     /locus_tag="KRO40_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentose-5-phosphate 3-epimerase"
                     /protein_id="HBH2090983.1"
                     /translation="MKHIKIAAGLAHVNYGHISAVVKEAMDAGVDYVHSDAADMHDLK
                     NMQLMGGHQIIEAIRPVTDKPIECHIYTRDCDRLFIEKIAAAGCNLLIIPAEHFLGAP
                     LAYIINYCREFGMKVGLTIGCYTPLCFVDEAIYDIDRLQIVVHGVDETDGKDNWGWRK
                     SAVDLVKRARKMIDEKNPKCELAIDGGLRSDNMEPLIECNPDVVILSSAIFKDKDGIT
                     AGVKNCRKAIDEAATKFGLE"
     gene            56574..57788
                     /locus_tag="KRO40_000139"
     CDS             56574..57788
                     /locus_tag="KRO40_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBH2090984.1"
                     /translation="MRNCIIAQSGGPTAVINASAVGIYEKNLETKYFDKVYFGINGIE
                     GILNKNIIDSDSLNKDNVLNLKQTPSSGLGSCRYKLADYKINSYDYDRVINILDEYKI
                     DTLFYIGGNDSMDTVMKFSQYCKNTTCKIKFIGIPKTIDNDLLGTDNCPGFGSAAKLI
                     STLIMETYLDFSIYKNNGIFIVETMGRDTGWLAASSSLARLNDTPLVDLIYLPEIDFY
                     EDKFIEDVRKIFKEKNKAYIVASEGIRDKYGNFICEQKTSAHDKFGHSQLGGVSNYLK
                     NLIVSSSITTRVKTLELGVIQRCAMHLASDTDLKQAAEVGAYGIELSKKGYTGVMAII
                     NRTCNNPYKYEVSHTDISKIANKTKYFPKEWINEECNYITNEALNYLYPLIQGKPDIK
                     YKNGLPYFSIIY"
     gene            58406..59734
                     /locus_tag="KRO40_000140"
     CDS             58406..59734
                     /locus_tag="KRO40_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090985.1"
                     /translation="MMKIAVITTEFLKEFVDNSIKKLNINAEIEIYIYRDFSHVGDLY
                     LEIEDRFDGFAVSGPIPKKAITKKAGTIKKPLVDFGTDLQSYYDMFLKLIFKYNTLDF
                     SRAYFDLTDWADNPKDISYYLSNGTFGDLMDSIDENASKMSLSDIAKLEKKIAKKHIN
                     LWNEGKIDFSTTRFSSIVPMLQNAGVNFHFIYPDIDLLKNTFNNLIKDIHLHRMKGNQ
                     PSVIYITVKDTNYDDSTLDQVYKILNSIKKDKLTDFIIEKNSNSFKIFTKCETIKSLT
                     KNFTACYIKESIENSTNIKVCVGYGIGNDIKQAMSSAISANKESKINHLNYSFLVNEN
                     YETIGPLLCDKLLTVSNKVTPHINTIAKSSKLSTLTIQKIISVTEILQRDEVTPKELS
                     SCLNVTVRTANRFLSSLLKSGNATILYEKQNSTKGRPERVYKLFISENKY"
     gene            complement(59862..61052)
                     /locus_tag="KRO40_000141"
     CDS             complement(59862..61052)
                     /locus_tag="KRO40_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2090986.1"
                     /translation="MKNFFKEAQSIEGEIIRWRRYLHENPEIGCNIPKTVTFVTSTLE
                     KMGYSPKLTSNNGIVAVLDSENGGKTLLLRADMDALPIMEETDLPFKSKNKDASHSCG
                     HDNHTAMLLGAAKILMDNKHLLKGRVKFVFEPDEETTRGAKSMIDDGILENPQVDAAM
                     AFHSMVGKFLNTGQVAYSRGPAMASADIFEITVEGKATHGASPEFGVDPINIMSHIQI
                     ALNTILSREKPQKEPVVLTIGMFNAGNVPNAIPNKASMSGTLRTFDQFVREKLKNRII
                     EISTGIAKSFGGNAKVEFKMGTPAVINDLDVGDEIVSYVKEVIGNENVIDFPSAMGSE
                     DFSEILLRVPGVFLWIGMGSISQGYNFGMHNPKAIFNEEGLVYGSALFAHCAVKWLEN
                     NFSR"
     gene            complement(61158..62537)
                     /locus_tag="KRO40_000142"
     CDS             complement(61158..62537)
                     /locus_tag="KRO40_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2090987.1"
                     /translation="MIGSISINEIDKKRFKLDDLSKKIWENPEKAFKEFKACENTANF
                     LRSEGFDVEVGVGGLATAIRASFGSGKPVIGFMGEFDALPGLNQKVSTKQEAFELGAY
                     GHGCGHNLLCTAHVGAVVGLKREMIENNLSGTIVFYACPGEEQLTGKGFMARGGAFEG
                     LDLAINFHPNKISEATIGTSTAVNSVKFHFKGKTAHAGSDPQNGRSALDAVELTNVGA
                     NYLREHVTSDVRIHYTITDGGVAPNIVPDKASVWYYTRALSREAVESTYERLVKVAKG
                     AAMMTETEVEVEFLGGCYNTLNNHVLANLVSECMNEIKQEPWTREELDFAAELDRQSP
                     QQYKAMISKYNLPEGTHLYYGGGNVTNFNSYGSTDIGDVMHIVPTAYFFTGCTNLGAP
                     GHSWQFTSCAGSSIGEKGMIYASKIMAMFGAKILNNPEIAKKAKEEFDKSMNGKTYKC
                     PIPDDIPTP"
     gene            complement(62568..63776)
                     /locus_tag="KRO40_000143"
     CDS             complement(62568..63776)
                     /locus_tag="KRO40_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2090988.1"
                     /translation="MENFWNPLTCFTVCVMIYAFSEFLSKKTKGAISTLLFVCIIFLI
                     GFWTNILPKDITGASGILAAMSNFGIALLITNLGTLINLEDLCHEWKTVVIALVGIVG
                     IGVGCLTVGSMLFGREYALIAAPPIAGSTVAGIIVTTVAEAANRPELAAFVILVLSFQ
                     KFFGIPITTYCINKELKFKRDNGDFLKDESKSNFKLPSMRIFKEDLGKKSSTLVYLAK
                     LSFVAMIGNFVGLATLIPGFTPANYYLNPNIACLLVGLIFTRIGFLEKGILDKSQSNG
                     IIMFGCMLMLPGGLAKVTPTALFGMIVPTIGILVVGSVFIILFTAIVGKLLGYSPRMS
                     AAIGVTCMLAYPATQIISNEGIDAMEGTEEEKQRATDYLLPKMIIGGFVTVTIASVAF
                     ASIIGPIIFG"
     gene            complement(64801..66255)
                     /locus_tag="KRO40_000144"
     CDS             complement(64801..66255)
                     /locus_tag="KRO40_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH2090989.1"
                     /translation="MNIKDTFFWGGSIAAHQCEGSWDSDNKGPAIMDFVTKGSYETPR
                     VITDKIEEKLDYPSHNGIDFYNRYKEDIALFKEMGFSALRISIDWSRIFPNGDDENPN
                     ELGIKYYEGLIDTLIENNIEPIVTLYHFELPMNLVHKYGSWNNRKLIDLYLKYSETVI
                     RRFDDKVKYWVTFNEMNHIDPQTEHSDIFTYMIAGIKYSEIENKVQTLANVGYNMTLA
                     GVKVAKLAREINPNNKVGCVFGLNPIYPYNCNPSNVLNAFLDNDRDYYQIDAMCNGKF
                     PQYKLKEYEKNNITIEVTDEDKKAFKEGKLDFIGLNYYFSSVSTPKENLSGDKSLFGG
                     IQNPYLEQSKWGWAIDPIGLRFTLNYIYRKYQLPILITENGLGAYDKIEEDGTINDDY
                     RIEYLSKHLSQMKSAIEEDNVECFGYLMWGPIDLVSATTGQMSKRYGFIYVDLDDEGK
                     GSFKRYKKKSFDWYKEVIKSNGEVLDFSTDIVVG"
     gene            complement(66275..68146)
                     /locus_tag="KRO40_000145"
     CDS             complement(66275..68146)
                     /locus_tag="KRO40_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2090990.1"
                     /translation="MKYKDLNENIIKLIGGKENIKSVAHCVTRLRFTLNDRSIAQTEE
                     IKKLKGVIDVVSNDVAYQIIIGTHVVDVYNEFMSMIGLSSSESSIKSERKKGIRGIKG
                     IFNSIFVVVSETMTSVIEVLLAAGILASMLALLNMSGILQSDSPTYQILDTLRSATFH
                     FLPVLIAIASAKRLNVNPYIAVVLAVTLLSSSIDGVEGLSLFGINLQATTYANSFIPI
                     LLGVWAMGIIIEGLKKILPKALHYFLVPVLSLIITLSITLTVFGPIGMWIGDGLNYAC
                     MFLIDTLGNWSVVALYAALQPLLIVFGAANFTMPISLNSVTTLGYDPIFMGAATISDI
                     AVCGAMFGYFLKTRNKEQKQLFGTVSFSALMGVTEPSVFGVFMKYRRPFVAVMIGGGI
                     GGLIAGLAQVKTYGMVWGLAALPTYLVGGEVSNFTFMIISVVVSFVAATAASYLLGIP
                     SDEKEEVKGDNEKELELIINENNSRTISIGNVAKGQVIALGEVNDKAFSSGALGKGVG
                     VIPSESKSTVISPVDGTITIVFPTKHAYGIVTDEGLEILIHIGIDTVNLDGKFFESLV
                     TQNQRVKKGDALAVFESDKIIEEGFDSTIITVVTNTSDYLDVISSNDESEELLTVIV"
     gene            complement(68136..68996)
                     /locus_tag="KRO40_000146"
     CDS             complement(68136..68996)
                     /locus_tag="KRO40_000146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2090991.1"
                     /translation="MKIIQILNNNVALVKRGKNEIIVFVKGIGFKKRVGQVINENEIE
                     RTYILDSYDMLEHFSYLLQNSDSNNIVLINEIIEYGEKALNIKSSDYLSLTLLDHLEF
                     LLKRCEKNQFIKSPLVWNVKRFYPKHFEIGMHALKLIGDSKGLNLPDDEAVSIALHFV
                     NMEVNKESHDSTIVELRTLADIVSIIKYHFNVELDETSTNYMRFTTHLQYFIQRIMSD
                     EASIDEDNSIDLYKQVSQLYPKSFGSVQKIRKYIKSQFNVDISISEETYLMLHINRVT
                     QRLEAKSDEI"
     gene            complement(69591..69995)
                     /locus_tag="KRO40_000147"
     CDS             complement(69591..69995)
                     /locus_tag="KRO40_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="HBH2090992.1"
                     /translation="MKKYKVIFIVLIIGIISVTGFVVYKNCIKPWKDAETYIDKYMVK
                     QDISKDNIKSITKEKAKKASYEGILYKVYYKDDPRYEYQYFYSDNYYALYVNKVMLQI
                     YDMENNNKLLRSNEELKSVKYPPIYLKYKPDK"
     gene            complement(70187..71374)
                     /locus_tag="KRO40_000148"
     CDS             complement(70187..71374)
                     /locus_tag="KRO40_000148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosyltransferase"
                     /protein_id="HBH2090993.1"
                     /translation="MSKIVFFSIPAYGHTNPTIEVVRELVDRGNEVLYYSFNEFKDKI
                     EGAGAKFICCDKYLPELLPGDEKKIGKDFPGLIEMIVDTTISLDEKVCRELKDFNPDC
                     IVSDSLSFWGKLFAQKLNIPYVCSTTTFAFNKHTAKLMKQNFIEIIRMIFGVRRINKK
                     IKLLQRKGYEVKNFISIVSNDNDTDTIVYTSKEFQPMVETFSSKYSFVGPSVSKLIIE
                     PKERKRKLIYISLGTINNKNVSFYKNCISAFKDSDVDVIMSVGRSTDIKSLGNIPNNF
                     EVKNSVEQIAILQKTDVFVTHSGMNSVNESLYYGVPMVLFPQHSEQRMVAKRVVHLGA
                     GIMLKEDKSESIKKAVFQVINDNEYKENATKLSKSFYNAGGSKKAADVILQIICNSRQ
                     VDI"
     gene            complement(71406..71831)
                     /locus_tag="KRO40_000149"
     CDS             complement(71406..71831)
                     /locus_tag="KRO40_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2090994.1"
                     /translation="MINENLKSLRKINQYTQEELAEKLNVSRQSIAKWESGESIPDIC
                     SCIKLAKLYNVKLDDLVNHSEEKTGIIVPPKGKFFFGAVVVGERGQIVIPKEAREVFN
                     INAGDKLLVLGDEERGLGIVHQRDLINFIGHVGVVRKEE"
     gene            72289..73038
                     /locus_tag="KRO40_000150"
     CDS             72289..73038
                     /locus_tag="KRO40_000150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440038.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH2090995.1"
                     /translation="MILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDELISA
                     DKPFIFVCPTYAWRLPIVVTDFIKETKFLGSNRVYFVMTCGGDTAKSINYIQKLCKYK
                     EWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFETITPS
                     GLGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNN
                     CTHCMACICGCPTEAIEYKNKTQNRERYYLE"
     gene            complement(73204..73569)
                     /locus_tag="KRO40_000151"
     CDS             complement(73204..73569)
                     /locus_tag="KRO40_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2090996.1"
                     /translation="MEKECQQRMQEITSKFKECRKAISAMGDETRQLILIALLESDFN
                     GIRVGEITKKTHLSRPAVSHHLKILKEAEIVNLRREGTKNYYYLDSKKSQWKSLTELI
                     NLIFVGIQHISENDIRKGD"
     gene            complement(73585..74361)
                     /locus_tag="KRO40_000152"
     CDS             complement(73585..74361)
                     /locus_tag="KRO40_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2090997.1"
                     /translation="MKYQHIIEVDKELCIGCGLCKNDCPVNNIIIENKKSVIKKQDCL
                     MCGHCAAICPTKAITLTGFDEPPIELTNKPKLDSDELLMAIKSRRSIRKFKDKEVSSE
                     IIKQIIEAGRYTPSAKNSQDVSYIVLDNKKSIYENEAVKFFRKIKPIANIAIKYSKEV
                     EIDDNFFFKHAPIAIMIITKDKISGSLAASNMALMAESYGLGVLFSGYFSDVANNSPK
                     LKKLLGLKRSNHVLTTLVIGYPDVKYRRTAQKEVATVRYL"
     gene            complement(74808..76235)
                     /gene="ascB"
                     /locus_tag="KRO40_000153"
     CDS             complement(74808..76235)
                     /gene="ascB"
                     /locus_tag="KRO40_000153"
                     /EC_number="3.2.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBH2090998.1"
                     /translation="MSFKNDFLWGGATAANQCEGGYNEDERGLANVDVCPTGKDRTAV
                     ITGKLKMFDFDDEHYYPAKTGIDMYHNYKEDIKLFAEMGFKVYRMSIAWSRIFPKGDE
                     ETPNEKGLQFYENIFKECKKYKIEPLVTITHFDCPMHLVKKYGAWRNRKMIGFYEKLC
                     NVIFRRYKGLVKYWLTFNEINMILHAPFMGAGICFEEGEDVEKIKYQAAHHELVASAI
                     ATKIAHEVDSNNLIGCMFAAGSVYPYSCNPNDVWEATKLDRENYFFVDVQSKGKYPNY
                     ALKYMEQKGITPEMEPGDIELLNKYTVDFISFSYYNSRCVRTDENADDMAEGNIFTSA
                     KNPYLSYSQWGWPIDPLGLRITLNHVYDRYEKPLFIVENGLGAKDIADENGYVEDDYR
                     IDYLREHIKAMHDAVSIDGVDLLGYTTWAPIDLVSAGTGEMEKRYGFIYVDRDNSGNG
                     SLRRMKKKSFEWYKKVIASNGEDLY"
     gene            complement(76296..78224)
                     /locus_tag="KRO40_000154"
     CDS             complement(76296..78224)
                     /locus_tag="KRO40_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2090999.1"
                     /translation="MGKYKQLAQEIVNNVGGKENISGLVHCITRLRFTLKDESIANDN
                     VLKNMEGIVTVMKSGGQYQVVIGNHVEAVYKDVVEIIGLDDSSTSSETKKSGNILDKG
                     IDIISGIFQPVLGIMAACGMLKGFNALFVAMGLYSDVSGGYMVINAAGDALFTFLPLF
                     LGYTSAKKFGLKPMLGLALGAAVCYPAIQGSSISAGADVMYTLFKGTMFASPVYIDFF
                     GLPIVSIDYTGTVVPIIFIVYFASRCEKLFNKCVPNLVKFFFVPMLTLLITVPVALIV
                     IGPIATFGSTLISQIVISIRDFSPLLAGAIVGFTWQILVIFGMHWGFIPVYINNVMTL
                     GYDNVMMPFFACTFASSAVVLAIFFKTKDKKLKEMAIPNFISGIFGVTEPAIYGILLP
                     LKKPFIISCIASGIGGAFYGFFNLRKFITGGMGIFELPAMIEPDGGMGNLIVALSGIA
                     ISMVVAFVLTMILYKDEKVEESKKVRNKGKEEIKEVKSTKLEREIVTSPIKGEVLKLS
                     DIEDAAFASGVLGQGVAIIPSDGKVVAPVDGVVTTLFPSLHAIGILSDTGVEVLIHIG
                     LNTIQLEGRGFEACIKQGDRITKGQTILNFDVYAIKELGYSTVTPIVITNSSQFLDVV
                     ETESKNIELEDNLITVLF"
     gene            complement(78369..79211)
                     /locus_tag="KRO40_000155"
     CDS             complement(78369..79211)
                     /locus_tag="KRO40_000155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2091000.1"
                     /translation="MIINKILNNNVVITLDDNDEEVIVMGKGIGYQKSKGNLIDKTKV
                     NKVFRISNKEISNKLQELLNNIPIEHMKLSSEIIEYAQIKLNKKLNESIYISLSDHTY
                     SAIQRMKEGINVKNAILWEIKRFYKEEFEIGMKALDIIENKTGIKLPEDEAGFIAFHI
                     VNAQLSEGHTLASDITKLIQEVLSIVRYHFRIEFHEESVFYYRFIMHLKFFAQRLLLD
                     SAHEGETDKELLSIIKSKYNKEFECVVKIKNFIKKQYNYILTDDELIYLTIHLAKVVK
                     DSNM"
     gene            complement(79558..80922)
                     /locus_tag="KRO40_000156"
     CDS             complement(79558..80922)
                     /locus_tag="KRO40_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2091001.1"
                     /translation="MKNKYEEVAQLIIDGLGGKDNIIDLTHCMTRLRFILKDEKKVNA
                     DKLKSIDKVVGVNSTSTQYQVIIGNEVGVVFNAIINKGINTTGDIKSDIKNKKNSILN
                     NIIDTITGCMTPMIPALTASGMIKVILSLCTTFNWLSSNSSTYRVLDIIGDVAFYFMP
                     IILAINAAKKFNVNTSIAVIVVGVFLHPNFSAWVSSGDPISFIGVPIQGVIYVASVIP
                     ALLTVWMMSYIEKFIDKLTPSMLKTILNPTLVLLISAPIALIVIGPIGNFLGEGLASI
                     INLLQGRLGFIMVCLLAAAMPFIVMTGMHHALTPIFISAFATTGQESLILISQVCANL
                     AQGGATLAVALRSKDSKMKQLASAAWISAIMGITEPALYGVTLKLKKPAMLASIGAGI
                     AGLFAGITHVTLYVPQNSIMAVLGLSGEKGISNIVNGLIVIFIALVAPFIMTYVFGVE
                     KNVK"
     gene            complement(80961..81632)
                     /gene="pgmB"
                     /locus_tag="KRO40_000157"
     CDS             complement(80961..81632)
                     /gene="pgmB"
                     /locus_tag="KRO40_000157"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBH2091002.1"
                     /translation="MKAVLFDLDGVITDTAKYHFEAWHEIAKSLDIEIDETFNEKLKG
                     ISREESLDKILLSANKVDSYTKEEKLKVCEEKNNIYIKLINSLTYKDILPGINELIKE
                     LKKNNVKLGIASASKNAPRILESLGIKDEFDCIVNPSLLKRGKPYPDIFIEGSKILNL
                     KQYDCVGIEDSYSGIKAINAANMTSIGVGKKEVLGKCDHIVEDTSLLNCNTLLQAWSK
                     KINLD"
     gene            complement(81634..84024)
                     /locus_tag="KRO40_000158"
     CDS             complement(81634..84024)
                     /locus_tag="KRO40_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBH2091003.1"
                     /translation="MSLIFTTKDQLIEQGFSKDTIKSNETLFTLANGHLGVRGNIEES
                     DFNNEYVDNMGTYVNGFYEESPITYGESAYGYAKQNQTICKLPNAHIVNFSIEGDYFD
                     LSKGITSEHSRILDLNEGILKRSFIWENSCGRKVKVSIERLVSQDIEELMMISYTITP
                     LNFNGKIKFKNKMENSMEKFNCEKVDDPRVASINKKQFKINVKKYNNKYFMNLVTERS
                     RLGLWCGFDSYITCGNITNETYNVSDECIEREIEVYAKKDERLNLEIVVGYSRVYSDL
                     NLNEERLKSLECLESLKCLESEAHLKSLELVLREACNIGFDKVKNIQRKKMNEFWTTS
                     DVEIEGDKTLQLGIKTNLFHIYQSAGRDGKTNISAKGLTGDGYEGHYFWDTEMYILPF
                     FIYTQPSIARALLDYRYSILDASRERARELGINKGCLYSWRTINGNECSAYYPTGTAQ
                     FHINADIAYGIRTYFEATNDEEFMMQNGLEILIETARFWVEFGDYIESKNNKFCINGV
                     TGPDEYTAIVNNNYYTNLMAKYNLIYAVQMVDKFKHNLFSNEVFRKVKLQEYEVKNWI
                     NAAQNMYLPYDEEKKISKQDDSFLEKSVWDFKNTPKEKYPLLLHYHPLTIYRYQVNKQ
                     ADTVLSALLFPDEFSLEQKKRDFEYYEKITTHDSSLSRSIFGMMASEIGNHEKAYNYF
                     MDTALMDINNLQKNTSDGIHAANMGGTWMSLVYGFAGMKIKNDKLSFEPRIPKHWKNI
                     KFNILFRDNLVSVNIEEYKSYYKLIKGRNITILHDNKEIKLSKNIIEVNNCFKGSN"
     gene            complement(84050..85498)
                     /locus_tag="KRO40_000159"
     CDS             complement(84050..85498)
                     /locus_tag="KRO40_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH2091004.1"
                     /translation="MKLGKDFLWGGAISANQSEGFYLDGGKGLSQFDKLPLNDKRLKD
                     VCLDEDNILNENNQYYPSHIGIKFCENYKEDIAMLAEIGFKCFRFSISWSRIFPTGEE
                     SEPNEKGLQLYDNIIKELKKYNIEPLITISHFDIPYSLVEKYSGWADRRVVNLYVKYA
                     EILMKRYKDDVKYWIPFNEMNMIMHIPYIGAGLTFIADENQLQKKYQAAHHQLLANAK
                     TIEIGRYINKEFKFGCMLAAGKTYPYTCKPEDVFATLEHERYNLFFSDVQVRGVYPSF
                     MNYYLKSNQIKLIIKEEDLSTLKDNTVDFVSFSYYSSACSSARAEGLEKSKANGPETI
                     KNPYLPKSNSVWQNDPVGLRITMNQLYERYQLPLFIVENGLGTQDIVNEDGKIIDDYR
                     IDYMKEHIKNMILGVNEDGIELIGYLMWGCIDVTSVSEGKMTKRYGIIHVDSDDYGRG
                     SFKRTKKQSAFWYKKVIETDGEILFNDMETHA"
     gene            complement(85901..86788)
                     /locus_tag="KRO40_000160"
     CDS             complement(85901..86788)
                     /locus_tag="KRO40_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2091005.1"
                     /translation="MAIYLEMPKLIHEFPFRSLSNEGEVLTTPHWHKEIEILLITEGV
                     VNLFINDKPMQLKKGEIVIIKGGDIHYILPSPGSERLVFQFDISFFNDLILLNEEKES
                     LINLFSSIKKCSRDWSAKIRKSVFDILIDIYNEDLYKIEGYSYAIKGKMYNLIPILYR
                     QIPREIEENTVEYEINSKEILERLNNIFKYVEKNYKQPIKLEDVSYEVGFSVYYFTKF
                     FKKNTGKTFITFLNEYRLEKAKWILLNNNISIVDLVEEVGFGSTKTFYRVFKEKIGVS
                     PLEFKKRYNSLEKKGSVSK"
     gene            complement(86888..87337)
                     /locus_tag="KRO40_000161"
     CDS             complement(86888..87337)
                     /locus_tag="KRO40_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2091006.1"
                     /translation="MEIREILTEESIILDLKSTTKEGIIQELVDKLYDTGSITLKSKF
                     IKALKHREKIGSTSIGYQMAMPHGKTKYVKKASIVIGKSKKGVDWPSIDGLPVKVIIM
                     FAMPQSGGNEDMILISKIAYILGGKNIGERLLNANTKKEILDIFYEV"
     gene            complement(87327..89234)
                     /locus_tag="KRO40_000162"
     CDS             complement(87327..89234)
                     /locus_tag="KRO40_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2091007.1"
                     /translation="MLVSRQIEFLKLILNENKYRPIKYFKDKLNVSDKTLQKDLKMIE
                     KYLETFNIKIDIKRGYGILIEDLAKKNIDLINSLNIQSKENKSLSVEQRRMEILKYLL
                     LNSNNITSINQLADKYYVSKTSIVNDFKYIEAWIKEYNLKLNKTLEGTKIIGKEVDIR
                     KSIAKMMDDLLDENYEQHDISELTRLDSATFSALINLFDIDSIIFVETIITELEYNLG
                     YTINQPYYINLITHILICLKRIEEGNQIESQEEREISVDNLDELVYKNVSTLIDKIEN
                     RYRVKITKDEIMYIYIFLVSSGFSSENNSSYNDESDRLSESEKVSSIMIENMSRFLNI
                     NLKNDDLLQKSLASHVRPMLNRLRYDIQIKNPLLGEIQERFSDVLGLCMMTINIMTEY
                     DNLKNISIDEVSYLATYFQAAIERNMSSKRVIVVCHTGYGTSQLLAARLKREFPEWTI
                     VDIVPMHQLSKRNLDDVDFVISTVNLDLKDKLHIVVSVLLMENDINNIKNALLSKPKK
                     SMNLDTNLLGMYLEDNIYFNFDVAQMESLIGVNLGSKYESISLGKDLNIYIHKQSKLN
                     KGIMNINNVTRTIDIYLEISNQSFLKNILMEISNLYRQKNYINYIIDCKSKEDIKILF
                     KNNLLEKTNGN"
     gene            complement(89502..91397)
                     /locus_tag="KRO40_000163"
     CDS             complement(89502..91397)
                     /locus_tag="KRO40_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2091008.1"
                     /translation="MIGKILRSDCIVLDKQLQTKKDVINYMANHLYHGNYINNKEKFI
                     ADINKREKESSTNMGNLIAIPHAKSNVVNQPVMMYLRTDREITDNDGQKLRSFFMIAV
                     PESGSDEHLKIISKLATYLMEENFLKHLLSAETPYEILSIFNNKAAESGDFSNNQNKG
                     LIVGITGCPTGIAHTFMAKKALEEAGQELGYEVKIETHGAIGVENKLTKEDIKRAEYV
                     IIACDKEVQLSRFIGKKVLQKKVVDAKNVSLAKNLIINAENGMAKEIKPGGKTLEDSK
                     EMLQGSEKKGVYKHLMSGVSEMIPFVVIGGIGIAIAFMFGIFASDPTHETYNPIAGFF
                     GQLGGDSAFKLFIPILAGFIAKSIAGRQGFAPAMIAGFMAVIGGSGFIGGMVAGFATG
                     YIALGVMKITENLPDVLKGVNAVLICPLLIAFTSGAIMFFVVNTPASWLNEALQSWLQ
                     SMSGTNKVLLGAILAGMMASDMGGPINKTASAFGLAMFSSNIFEPSAALMVGGMVPPL
                     AISLAMLIFKNKFTKEERKSSLPTAIMGASFITEGAIPFAAADPLRMIPANIIGSCIG
                     GAICMSLDITLMAPHGGIFVIPFACSAPVAYIACILIGTVITALIIGVTKPTIRSENS
                     EVELLGA"
     gene            complement(91433..92311)
                     /locus_tag="KRO40_000164"
     CDS             complement(91433..92311)
                     /locus_tag="KRO40_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketose-bisphosphate aldolase"
                     /protein_id="HBH2091009.1"
                     /translation="MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPV
                     ILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGENKEQILRAIRCGFTSVMID
                     GSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKD
                     FVEKTGVETLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEI
                     AQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKSAREVIEFKMN
                     LFNAIDKLKCFYKNKN"
     gene            complement(92854..93024)
                     /locus_tag="KRO40_000165"
     CDS             complement(92854..93024)
                     /locus_tag="KRO40_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091010.1"
                     /translation="MSALLYGVCNKSISVSIVINMQEFKIGVSMAYGVLVIGICYIAL
                     GIIFKLDRKRFT"
BASE COUNT        30378 a        16563 c        10024 g        36323 t
ORIGIN      
        1 acatttttat taataattta attagatagt atttgtatta ctttaattaa acgtaacctc
       61 ttgatataaa tttgagctat aaatctatat caagaggtgc tattttattt ttaatataat
      121 taatattcta ttacgcaaaa aatgcatata tttcattatt ttatggaaaa tattacttca
      181 tttaactcta tatcaaactc attaagtaaa aatctaatta tatttaattt agcctctgta
      241 tttaaatttg tttctaaata tatattttct gatattttaa taccttttct taatttatat
      301 gcatctctag acttaatatt atctataaaa tctcttttat aagttttgtc tacaatactg
      361 ttaaacctta cagaatccaa atcatataaa gtaagagcaa cttgttcata aaattctgtc
      421 caatttttag ccttatatga ctctcctaat atactaaatg atactatact ttcatttgta
      481 aaattaacat catcatcctc taacgtaaat atattttcac tgttacttgg aggttcatat
      541 gtaacacttg gatatttcca aatttctaca gctctatcta gtaatatctt agttctattt
      601 tttatttctt cttcattcca cttatctata gatgaaatat atttatttag ataaagtcta
      661 ctatctttaa atccatcttc catttctttc ttttcttcaa atgttttatt acttagtttt
      721 gaattatatc ctgtcaaagt taaatttcca attgtatgta aatatttatc atgtatctcc
      781 ttatagttat ctcctagtga ttccttccat ttatttgtta atgtctgtgg cattatatgc
      841 tctatattta gcatattatt attgattaaa ttttctaaat caacaatttc tttattatta
      901 taattctcta acctctcaag tatatataac ttattctttg acttagtatt atatatatct
      961 ttagtttcaa aagcatttga aaattcactg tcagtaggaa atctttgaga tgatttctta
     1021 tttataaaaa tatatcttaa tatattagaa tagttttctt tataatcact aaatttttta
     1081 atttcccttc ctaagttcat aaatacttta ttcagtgcat taggaggtac atcacatact
     1141 attcttctta atataaaaca ttctactaaa ttaagggatt ctacaagtac ttttttattt
     1201 attatacctt cattataatc atcaaataat tctaatataa acggatatga tacaaatatt
     1261 tcaagtttgt ttatcctttt caaaactttg tttacatcat tatcatcagt acatgaataa
     1321 gatatctctc tataatagtt agaaaattta agtaaatctt ttaataaaat ttctatatct
     1381 ataccattat ctgatacata ccttttaaaa ctaaaatata ctttattttt attcggtata
     1441 cttctctcct ttatagtcaa atagtctctt ataaaactac ttacgttgct acttgtattt
     1501 ttttcaattt tataccaata attattataa aattcctctt gtaacttaga gcttctaccc
     1561 attaacacaa agtttcttac tctatcagct tcacttaaat ctaagccagt tgaatttaga
     1621 ctttcaaaga ttaattgagg gtcatcttca ccatttttta actctatttc tactatagtt
     1681 aatttctgta tagcatcaaa caaatcatct attgatatat tatcttcttt tattctatta
     1741 taaaaatata aataatttga aactatatta gaatttctat ctgtattcat ttcttcttca
     1801 aatagttcat agtacgcttt tctatcttct gctattggtt ttaactttat ttttccatct
     1861 ttatctcttg agtgcttgtt tataagataa cactccttaa tctgttcttc tgttgtaata
     1921 attccttttg attccccaaa ctcttttatt atttgacaca tggcaatcaa taatattgac
     1981 acagtagtca ctctttgttg tccatctatt attaaatatt cttttcccat actatatata
     2041 gatacaactg accctaagaa atgagttcta aatccagaat ctattatatc ctctaaatca
     2101 tcaaacaatc ttttacattg ttctttcttc cagttataat ttctttgata tacaggtact
     2161 acaaaacttt tgtttgaccc ctctaaataa ctaagaaatt caatttctcc tgctttcata
     2221 ttaactcccc ctataagtta aataaattcc attcataact ccatgtatct atatattata
     2281 tcaaaatttt gactcataaa tgtatatgaa agccttatta tatacctttt tatacctgtt
     2341 tttattttat taaagtaaat acatgattat tctataaaat atacaaatac ttaattttaa
     2401 aaattattat ttaatcttct tcatgagtaa ttcatagtta tttatcaatt aaaaagagat
     2461 attgcataat tattcaatac ctctctttgt atatttacat tatccatatc tagttatcta
     2521 tttcaaccca atattagact acctactaat aaatttattc tctacatcat taacaataat
     2581 tttgcactaa ataacatcat tagcctatct ctgatgcatt ttctttaatt ttatttatag
     2641 ttttaatcaa tttatttctc tcttcaatat gattttcaaa taaatcaatt atacttccaa
     2701 cagttctaaa tgggtcttcc atcaacactt tgttatcctc tataaatcca ttcttgacta
     2761 cataatcgac tataagttta acaaaatgta tttgcttagt attaaagctc ttattattta
     2821 aaaactctga aaaagcttca tttgcagctt ctctatccaa tcccactagt cttctcacta
     2881 attggcttac tggagtatct ccaaactcct tcttataatc atcacaatta cctaactgtt
     2941 ttaagagtat ttcctccaac gtttcaacat cttgctttgt tatcttttta ttatttctta
     3001 atttaaatat tgctaattca tctttatggc tatttaaata atactctacc ttctttttat
     3061 aattcttaag attgtttgca ttatatacag aatcatttct atcttctgct acaatcatat
     3121 cttcaaaact tgtataatat atcttttgac tagacttttc aagatactta ataagctctc
     3181 ttaatgatat acgtacttct tctacctcaa atatatctga atcttcccaa aaatcctctg
     3241 tcattgcttt ttcaatagta tatttttgtt gctgaatctg tggtatagtc ccaagttttg
     3301 aaagtttttc tgctgtagcc attacatgcc ttataccttt acttgcatta ttattttgta
     3361 agtatgcaag ttgtatatta tacataacta catcaaatct tttagccaat tcatcatcac
     3421 tatatgaagt tatgagtggt gatatatatt ctcttatctc attttgtgct actgctccaa
     3481 tattgctcca aacattttca tttttatact tatgtacata acttaaattc atcctaacta
     3541 tataactatc ctcatttaaa gcttttacag aagttataag ttcttctaac aattcttttc
     3601 taagttctgc atactcacct tctatatatt taatatcttg aagttcttta accatactta
     3661 cctttatatt aaataatttt tcagtaagtg tttctgcttt atttccctca aatcctttag
     3721 gattaaattt aaaaaattca aaattattac aaaaatcaaa tattaagaat ctctccttat
     3781 ccatatcaac acctaataaa tctggacata atctagttcc tctacctatc atttgccaaa
     3841 acttagtctt acttctcact ttcttgaaaa aaacaagatt tagtatttca ggtatgtcaa
     3901 ttcctgtatc aagcatgtct actgaaactg ctatttgagg taatttattc ttatcagaaa
     3961 aatcatctat tatagaatct acataattta tactatagtc aactgctttt acaaagttcc
     4021 caccatactt tggatacagc ttattaaatc tttcaactat tgccctagca tgctttgtat
     4081 tctttgcaaa aattatagtc ttaccaatct tttcttgtcc ttctattttc aacccctctg
     4141 tcattagctt atttaaaact aaatctattg tgtcagaatt aaatagccac tcatttactg
     4201 cattattccc tatttcgtct ccaatactct catcatcatt aaatgtattt tcatattctt
     4261 ccttctcttc atcagaaagc tcatcatact taattccatc ttccataatc ttagtcttaa
     4321 actcaatact agtataatct actaaatatc catcctcgac tgccttatta tactcataag
     4381 catatgtagg tactccattt tccatgtcaa aaactgaata agtattttta tctatctcat
     4441 cctttggtgt agcagtaaga cccattaagt aagaatcaaa ataatcaaag attgacttat
     4501 actttttata aatacttcta tgcgattcat ctattataat taaatcaaaa tgaccaggtg
     4561 taaacaatct ctttccatcc ttagacttcg tatcatcaat tgcattcatc attgttggat
     4621 atgtagaaaa tatcatccta gcatcttctg ggctatcttt gctatccaat aaattacata
     4681 acgccaagtt aggtaatagc ttagtaaaac tttttttagc ttgctttacc aatgcttttc
     4741 tatctgctag aaataatata tttttaatcc aattatgtct tgaaagtaca tcaactatag
     4801 atatagcaat tcttgttttt cctgtaccag tagcacatac caaaagagtt ttgcgttgct
     4861 tattttcaag agcctcacat acagccctaa tagcttcttt ttgataatat ctattggata
     4921 tttcatcatt tattgttaca gaagttaaag acttcttact ctttcttcta tctatcataa
     4981 gttgtaattc tgatttttta taaaatccat aaactttcct atctgaatag tcatcccaaa
     5041 tatacatatc aaaaccatta gtcaaaaata ttaccggtct ttgactatat ctcttttcca
     5101 aacaatctgc atataattta gcttgttgtt gaccaatttt cgggtcttta ctcgttcttt
     5161 tcgcctcaac tactgctaat ggcttaccat tttcaccata aagaacataa tctacatatc
     5221 ctacaccact ttcattaggc ataccttgta cttctatttc ttcccatata tcttttccaa
     5281 attcccaacc tgcaagcttt aattctatat ttatatatct ttttcttgtc tcaaattcgc
     5341 ttacttcgtc tatcttgaaa tcatagtttg cagtattaac ttttctcttt tcagttagtg
     5401 actttcttaa ttcctcattt tcttttatta cttcttcaag ctttttatct tttgaactta
     5461 atctctcata aagattttta agttcgtctg gtctcgtcct tttctcttcc ccatgaagta
     5521 ataaatcttc attaaagtct tctgctgtat attcatctga ataacaatag tctatccaac
     5581 taacaaattg atgcaaattg ttaagtgaaa gtattgcttc tcctctctct atgttcgcac
     5641 tagtatgtac agataaatta cctaatttaa ctatatattt taataaaggt aacatatcat
     5701 agtctataag ttctataaaa ctattattat gaatcaacgt actgagatta tcttgataag
     5761 gcaatactaa atcactatca ttagcatata gccattttac tgcaagctct aaagctcttc
     5821 ttgttatagt tgcacaagta gatggactaa ctagtatact tttttctgct tctaagcaag
     5881 cagtattaaa actattgaaa tttttcttct tttgtaaaaa atcaaaatta cccaagcttt
     5941 tatccccctt ttgtccctta gttaaaataa atctctctaa aaactatttc ttacagctgt
     6001 ttcttatact aacaaatact tcttcatttt ctgtaaacaa ttcgtacata tcttcaaact
     6061 gtggtatatc atatccatga gaatcatcat ttctcaattt tctaagtgtt tctataacta
     6121 tagaagaatt tttaggtaat aaattgtgat actcacaagc taaaaggtag tcataaaagt
     6181 ttttagattt tatgtttaaa tcaattgatt tataatacaa cattgctttt gttaattcta
     6241 gaaatgatac catatagctt ttaaagcctt cttttatgta tctagcccat aactcaggca
     6301 tttcttcctt atcatataag attttgaagt tttgcaggtc atacaagcaa gaaccaaaat
     6361 ccctatttac ttcttctatt gagttccaag ataatttgtt tctaattacc atacatgtcc
     6421 ctccaatcta agatatctat tacatcactg ttttcaaaat agaatttatt tatataatcc
     6481 ttaaaatctt tagattcata aataacttca ccttctaaaa tagctttttt aagtgctatt
     6541 gtataattat ctgtaacaat ttttaggtct acatcaatgt ctaatatatt tcttagagct
     6601 tctgtcttag ttgcaagttc tgtaattggt acttttttga taggaatcca agctatgtct
     6661 atatcacttt ctgatgtatg tttatctgtt ccataactac caaatattat gattgctaga
     6721 gtattttctt ttggaaatac atttattatt gagtttttaa tctcatttgg tatatttctc
     6781 atttaatcac ctcttgttta ttaggtaata ttacttaatt aaatttatat ccataatctt
     6841 ttaatctatt tatacatatt tctctttctt catcagtaaa caactcttta tacttttctt
     6901 ttaatactaa tacttctaat gataaatcta atctcttaca ctcccatagt cttgtaaatc
     6961 cttcagtagc tccttcttta ttgattaatt ctttagcagc taataaggct cctttgttat
     7021 ttatcagttg taaaaatctt gttggcttat agttacattg taaatcagct tctttataga
     7081 tatttaccat gttatggtat aaatctagct ctatttgatt catagatttt attcccccat
     7141 tttaataatt gtattttagt tgaataactc tcctttaaaa gctttttgca ttaatgagtt
     7201 aaagttgtct tctagttctt ttaagctagt ttccatttca aacttcaaag agtttacttg
     7261 tttaacgaag ttggcaaatt gattttgaag tctaatagga ggtacaataa tatttatttt
     7321 tctaacagca tctttagtta tcgtttttgt tacagctcct cttactttct cttttatttt
     7381 actttccata taggatgtta gtaaaaggtt atataagaat atatgattca ctttatcttc
     7441 attaaatcta agcataaatt gattcatagc taaagatact ggtttattta aaaatggcat
     7501 taaataaact ttacctgcac tacctatctt atttattata acctcaccac caaacacctt
     7561 tgatttttca agataattat atgcatgttc atcgatatac ttaacacctt tttcaaagtt
     7621 attattttct aaatctgtag ttcttaccat taaggcataa ccttttgtat ctaaaagagt
     7681 tacattatct cttaaggttt cataactacc atttgaatga taatcagtta aaacatctaa
     7741 atatttccct atttctgaaa tttcccagtt tttttcattc tttgatggag taccaaacat
     7801 ctcaataaat cttgatttaa ctaattcatc caatacttct atttgctctt ttcttttatc
     7861 tattaactct tgagccttgt ctaaaacacg cactaccttt tcttgcactt ttaaattata
     7921 catgcgtatt tttatattag ctaatccttc attatttaaa gctgattgtg tagcaccttt
     7981 acttaaccta tttttttgat ttagaaaata actactattt aagtaatggt ataaatattg
     8041 aggcaatatt tcttttgatg gttttaaaac ataaaatcca gtcgatacta ttatattttt
     8101 attagtttta ttaataacta atgttttctt tgtgtccttc atttttgcaa atataacttc
     8161 tcctatattt acagtttgat ttgctctaga aggtttattt tcataagtaa ctatttctag
     8221 attgcttatc ttgttaaaat ctaagtttcc agtactaaga tatgagcgtt ctccatcaaa
     8281 cttttttaca ttttccccgc ttatactaac aacatctaaa atttttgctt catcaaccat
     8341 actctacacc tctaacattc tttctagttc ctctaatcca tccactatct ctttctctaa
     8401 cgccttaacc ctacccataa taacactagg agcatcataa actacttctt catacactac
     8461 ctctttatac ttattaatag ataaatcata cccattctct cttatctctt ccacatcaac
     8521 aaaaaaactt tgctctgttc tttttctatc tacttcacca tcaagattat caaatctctt
     8581 aataatatcc tctatatcac tatcctttat ctcatttctc ttatcatcca aagaataacc
     8641 atcagctttc atatcataga accatacctt atcagttcca cctgttcctg ttttagtaaa
     8701 tatcattata gctgtagata ctcctgcata aggcttaaac actccacttg gcattgatat
     8761 tatagcttcc aatttatgat tatcaactat ttcttttctt atcgatttat gtccacctgt
     8821 tgaaccaaac aatactccat ctggcactat acatgcgcat cttccaccaa tttttaaaac
     8881 tcttaaaaaa agtgccaaga ataataactc tgttttcttt gtcttagtca cttttaataa
     8941 atctgctgac actgcttcat aatctaaact tcccttaaaa ggaggatttg ctaacaccaa
     9001 tgtaaactta tctttatctg tattaacctc cgataaagaa tccttatact ctatattagg
     9061 attgtcaacg ccatgcaaca tcatattcat agcacctatt ctaagcatag ttctatccat
     9121 atcaaatcca tagaacatac cattattaaa atgctccttc agcccttgca ctaagaaaag
     9181 acttgaatga ttatccctta agtattgttg tgatgatact aaaaaacctg ctgaacctgc
     9241 tgccgggtct actataatat cttctggtgt tggtttaata agtcttacta tcatatctat
     9301 tatgtgtctt ggagtcctaa attgaccatt agtacctgct gtagccactt tggataataa
     9361 atactcatac aaatctccct ttgtatctct atccttactt aattctaaat tactaatacc
     9421 atcaactatt ttagataaca taagaggcgt aggaatttta aatattgcat ctcccatgta
     9481 ctttgcataa gctgagtctt tatttccatg taattttttt atgaaaggaa acacttcatt
     9541 ttgtactatt tcatacattt tttctgaatt tccttcatta gaaaacttac tccatcttaa
     9601 atgttgatgt tcatcattaa atatcctttc aaaagaaact cccaaaagag ttgcttctgc
     9661 ttcatttttt gtttctactt catccaatcc tttaataaat aaaagatatg taaattgttc
     9721 tataacttct aatggattag ttaatccacc agtccaaaat gtctcccaaa tcttgtctac
     9781 tttgctcctt aattctcctg taatcatata tgactttccc tccagtgttc ataaaataat
     9841 ttaaatatat attttagtcg tacgccttaa tagttagtgt cttatgttaa atccaagttt
     9901 ttactacaca gttattaaat tatttttcct atttacatgt tttagttaaa aaactaatgc
     9961 aatactctta ttttatgatt attatatata ccatacaaaa ttattttatc atatatccat
    10021 catagaagtc atctacctgg ataattctta ccatattata actttttaat attaatttaa
    10081 acttagaaag aactttttta tttaattata tcatcttcct tatttcaaat ttctcaatta
    10141 caatattaat caaaaaataa aataagatgc tgtctcaaaa tagatataat cttctttttt
    10201 attgtcagaa tgatgaaaat atatttaatt tcatacaaaa aagagtgcct catgaactaa
    10261 aaagttcatt ttgagacacc ccttaattta atcttactta ttctttccct ttattattaa
    10321 cacttcactg tctctattgc ttttcctaca catccacaaa cttccatcct actcttaaca
    10381 aaatctttaa ctgactctaa acctttttta ccatatttct tagggtcaat tacctctggg
    10441 tcagaattaa gcacattctt aactccattg ctataagcaa tccttaattc agttgcataa
    10501 ttaaccttgc aaatccctct ttttatagat tccttaataa cttcatctgg tattccagac
    10561 ccaccatgta atactaatgg aactgataca acatctctaa tttcagataa tctatctaaa
    10621 tcaagctttg gctctccctt atataatcca tgtgccgtac ctattgctac tgctaaagat
    10681 gatacccctg ttctctctac aaactctttt gcttctaatg ggtctgtata tgctccccca
    10741 tcaccaccat ctaaatcgtc ttccttacct ccaactttac ctaattcagc ttcaacaggt
    10801 atatctgaag gcatacatgc atctacaaca gatttagata ttgaaatatt atcttcataa
    10861 ctttcatgag aaccatcaat cataatagaa gtatatccaa ctctaagtgc ctgcatagct
    10921 agtccaaagc ttgaaccatg gtctaagtgc attgccacag gaacacttgc cttctctgat
    10981 gctaccttta cattcgctaa ataataatct agtcctgcat actttattgt tgaaggtgtt
    11041 gtttgcaata ttactggtga tttaagttct tcagcagcct ctattactgc cataaccatc
    11101 tccatatttt caacattaaa tgcacctact gcataatgcc cttcttgtgc atctaataat
    11161 atttgtttag ttgtcactaa tgccataatt tctcctccta tatgtttata ctgatttaat
    11221 ttcttcgtta tttaattttg atactatttc tctacttgtt ttgctattta ataactcatt
    11281 taaaaattct tcattcatta attttgaaga tagttgagat aatgttttta agtgtaaatt
    11341 atcaccatta tctgtagctg ctatcataaa tataatatgt gccaagcttc catcttctga
    11401 ttcaaagtca aacccttctt ttgatacacc tactgctaca cgtggtacct ttactgcatc
    11461 tgtttttgca tgtggtatcg ctatccccat accaaaacct gtagatgata tttcttctct
    11521 tttaaggatt tcttctttaa acttcttttt atctaaaaga acaccagatt tatcaagtat
    11581 tccaatcatt tcatcaatta catctgtttt attttttccc ttaacatcta aaattactgt
    11641 ttcttcgcta tataaagaga tattattaga tacgttttcc gattctgcac tttcattttt
    11701 atgttcatct tttgttgcat ttgtattttc tatagtattt ttctcattta ctactttagg
    11761 tgtaaccatc atataaagta cagcacctac taatgaacct acaaatatac accctaccca
    11821 taaaagtggc ttattgacta atcctagaac caaaaaccct ccatgtggag ctggtacttc
    11881 tattttcatt atataagtta aaattgatga tattgatgat gcaatcataa gtactggcaa
    11941 cacttttaat ggattttttg ctgcaaaagg tattgccccc tctgttatat gagtactacc
    12001 tagtatataa ttgattaatc ctgctgctct atcttcttct gtaaatctat ttttaaataa
    12061 agtagatgct attgctatta ccaatggtgg tgttatacaa gctgcagata cacctgccat
    12121 aaataaataa tttccctgtc ctagaagcat agttccagtt acatatgctg ctttatttac
    12181 tggacctccc atatcaaatg ctgacataca tcctattact attcccaaaa ttataggact
    12241 tgaattttgt aaccccgata gaaagttcat catagcattg ttaagtgctg aacatggccc
    12301 accaagtaac aacattgcta cacccacaag acctacgctg acaataggaa ttataaaaat
    12361 cgatttaaga ccttctaatt gtcgtggtaa ttttcttaac aaatgtacaa atagtttaac
    12421 taagtaacct gctaaaaatc ctgatatgat tccacctaaa aaccccgaac ctgtatcaaa
    12481 tgatatcatt cctccaacaa gtcctgccaa cataccagct cttcccgata tagattgagc
    12541 tataaatgct gccaatacag gaaccatcaa gttcatagaa tatccaccaa cagattttaa
    12601 tgtagctgct atttgattat attgttctga atttgggtca aatgaataaa tcccccataa
    12661 aaatgatata gcagtaagta ctccacctgc tactactaaa ggtaacatgt gagatacacc
    12721 attcattaag tctttataca acttttgacc aaacgataaa tttccttctt ctgcaatttt
    12781 actgcttgat aagtttcctt ttctaatagc tacttttcca tcaatacatc tttgtataag
    12841 ttcattagct ttatgtatac cttctttgac aggtacttct attactggct ttccattgaa
    12901 tctgtccata tcaacatttt tatcacaagc aactattatt gcatctgcca tttcgatatc
    12961 ttttgctgtt aacttatttt ctacacctat agctccattc gtttcaactt ttatgtcaca
    13021 ccctaattcc ctggctgaat tttttaatgc ttcttctgcc ataaaagtat gagctattcc
    13081 agttggacaa cctgttaccc ctagaatcat tttctttccc atttttatac cacctttctg
    13141 actcttatat tttttatata atcttccaca ttctccaaat tacctatacc attactttca
    13201 gccacacttg ctcctgttgc tgctgacctt tttaatgctt cttcaatatg ttctggattt
    13261 tccaaccata tacttaaaaa agcagctaat gcagaatcac cagcacatgc agagctgact
    13321 actgtaactg gttgagcact agcataataa attgattttc cattataaaa ataagaacct
    13381 ttttctccta aagttagcaa tatattttga gcacctttta aatgtagtaa tttaagtaca
    13441 tccttaatat cttcttcatc tcttacaata attccaaata tatctttgat ttcttcatca
    13501 tttggtttta tcaaatatgg attatactgt agtaactcct ttaattttgg tgaacttata
    13561 tcgagtattg tctttatact tttattttta caaattttaa atatatcctc atagtaatta
    13621 tcatcaatac caggaggtag acttccactt attgataagt aacttatatc ttctaatgac
    13681 tgtatcttat ctagcatatc tagtttttgt ttttcattta catatgaccc agagtttaca
    13741 aatttaaatt catcacttcc atcatttaaa aatatattta tacgagttgt atcttctacc
    13801 caagtaggca atacgtcaaa tcctctcttt tcgctttctt caactatata ttttcctgaa
    13861 aatcctccaa aaaatcctaa tatcttagat tctataccat aatgacctag tacaaaagtt
    13921 acatttaatc cctttccatt aggagaatat acagcatttg atgtacgatt tactaatttt
    13981 ctctttatcc cattagtaga tatattcata tctattgcag gattcgtagt taatgtatat
    14041 atcattgtct tcccccttgc tcgtgctgtg tatgttttca ttataataaa aaagtctatg
    14101 aaaatctttt cacaaataga aaatcgattt tcatagactt ttcaatttaa ttttcagaat
    14161 tattatatct gaccatataa tctataatta tcctagatat aatatacaag ggcaatctgg
    14221 aagatacttc atattcagaa attgatatat gttcatgttt gtatcctaca atatataaat
    14281 ccgaatactt tataagtttt gcactttcac tacaacagca agttataacc ttagctccaa
    14341 ctaaattggc attctgtgct gattctacaa gctctatggt atttccattc aatgaaaata
    14401 taattataag ttcgtctttt tttattgatt tagattttat tttcattatg ttggggtcat
    14461 ttataaaaac aacattaaaa tcaagtaatt gcaatttaag actaaactct tttgctacat
    14521 attcagtaag ccctcttgcc aaaatatata tcttactaga tttatttata gtttttatta
    14581 tattgattag tgtagttaaa gatatttgtt ctataactct ctgtgcttct ataaaggatt
    14641 tatttattat atcccccata ttttgtatat catcattttc atcttttact gttaatctat
    14701 acctaagttc attgaatcca tttaaaccac attttctaat tgctcttgaa acggttgctg
    14761 gagatgaata tgtttcatga gcaatctcta ctatagataa ttctggtaat attgattcat
    14821 tttcatttat aaatttaatt atttcaagtt ccgtcttcgt tagattttca gaattacttt
    14881 tgtttagctc aattatcata tgttatctcc ccttatataa gttttatttg tctaaattta
    14941 tcgagtaata taatatatta cctcttaact acttattttt atatacaatt aagatttagt
    15001 caatgtctat atatgtaaat ttataatata ataatttttt gcttaaagtt tattatgtta
    15061 tcttatagca ttttaaaata aaaaagaatt gtacctctac caaaatttgg atgaagtaca
    15121 atagatattc ctcatactga tatgtttatg attaaaagta taaatataaa tttcgctatg
    15181 aatcatataa ttaataaatc attttattta caattataac cccccttata aaactatatt
    15241 aataatatat acagtattta taaggggggt tgtttatatt taaaaactat ttacttttct
    15301 cttaattctt ctccattagt tcttattaca ttttcatacc aataaaaact atctttttta
    15361 taacgttctt tacttccatt tccattgtta tctatatcca catatataaa tccatatctt
    15421 ttttccattt cttgagatga acaacttact atatctattg gtgaccacat acaataagct
    15481 aatatttcgg ttccatcagc tatagcttca cctatttgtt ctatatgttt tcctaaataa
    15541 tctattctgt aactatcatg aacttttcca tcttcaaatt tatcatgcat tccaaatcca
    15601 ttttcagcta tcattattgg cttttggtat ctatcataat attgagataa agtattgtat
    15661 aatccttttg ggtcaattgc ccacccccaa ggatttgctt ttaaatatgg attctttata
    15721 ttgtcagttg gattcatggt gtttttactt gctgatactg ttgtagaata atagtatgat
    15781 aaagctagaa aatccatagt attttctttt aagattttat catcaccttc ctccataact
    15841 atatttatgt tattttcttt gaaaaatctc ttaatatata ctggatactc tcccctaaaa
    15901 cttacatcag tgaaaaaata ttgtagccta tttcttttta aagcaaatac tacattttca
    15961 gggtcacaat cttctggata agatgtacaa tctgccatca tcatccctat catcatatct
    16021 gaatttattt cttttccaag cttcttagtc aaagctgtag ctatgaattg atgatgaata
    16081 gcttgatatc tagcctcttc tacattatct acttggtcta cacaaaatgc aactgaatta
    16141 aatgattcat aatgtattaa atttatttga tttataacta tccaatattt aactttattt
    16201 ttatatctat ttagtattaa ttctgcatat ctaacaaaga aatctaccac ttttctatta
    16261 gaccatcctt tatattttaa tactaaattc aaaggagtct catagtgaag tagtgttaca
    16321 ataggttcca taccattatc tattacttca tttataagat tatcataaaa ctttaatccc
    16381 tcttcattag gctctaaatc atctccattt ggaaatattc tagcccaatt tattgaaaat
    16441 ctaaaacact ttaaccctag cgctttcaaa agctttaaat cttctttgta tgtatgataa
    16501 aagtctattc cactacactt aggatagtac ccatttttat ctttcatagc aaactttatt
    16561 ctttctatag tcatatcaga ctcataaggt ttagatatat ctctatcttt atcatacata
    16621 tgtacatcag ctaaacacca acctttgcca ccttcattcc atgcaccttc taattgatta
    16681 gctgctacag ctcctcccca taaaaaacct ttaggaaact tacccaattt aatcactcct
    16741 tattttattt atttaaatca tttactatta tttaccttat attctataga ctttactatt
    16801 cctactaaag acatagttat atttaactcg ctgaatatgg tcataagagt atcttgagca
    16861 tgtgcaaata acagcgaatg tgctcttttc tctccaccag cttccccttg tataatcttg
    16921 gtttgagctc tatgtgcttc tgtcataaac ccttttgctt tagctagttt taaatcagca
    16981 tttctataat caaacttttc caaatcatta agagcatgtt taatttctgt tctagcctca
    17041 cctgcacgaa gtattatttg cattgccacc tctactaatt cttcatctat tatatgttct
    17101 tcaattgtca tatttataat ttcctttcaa tttctaaatt taaacctctt ggctctctaa
    17161 ttttatctct tctttctcat aagctttaaa aaatggatac catatcataa atagcaatac
    17221 tatatttatt gctaaaacaa taagacctct aacatcttga tttaccataa aagtagatat
    17281 accaaaagga acataccata aattaaacac cttacttgga attgtcacaa atcccatact
    17341 cattgataag taagtagtta ttgatattac tactgttcct atccacatag gtaacattaa
    17401 aaatgggttc catgccactg gagctccaaa tattactggt tcatttatat tcattataga
    17461 agggacaata catgctcttc ctattgcttt tattcttcca actctggata aacacatcat
    17521 tataactaat ggtaatgtag cacccaaccc tcctaaagtt atccaacctg tttgaataac
    17581 ttcgtaaaca tatatattag ttgctactcc tcctgatgct actgctgctg cattagctgc
    17641 aattgcacca agttgaattg aataagttat aggagatagt acccacccac ttattcctaa
    17701 agaatatata aatactacta agaagtttaa gagtacaaat ccaggtaatg tctgtgctat
    17761 atctgatact ggtttaaata ctctaactat tatttcaaac atgtcaaagt tgagtccata
    17821 aattaatccc cagcctacaa acattatcac tgttataggt aacatattat caaaccactt
    17881 gcttacaaaa tccggaagtg ctgaatcttc tccgaaaaat gaaaaagaac caaataaaga
    17941 cattattaat ccagagaata atcctgcaac tagcgataca agcattcctt ctcctccaaa
    18001 cctgttgaag ttaaatatag ctccttcatt cgtaatctct ggacgaatca tcattaacat
    18061 taatccagca cctgcaagac cagctactac actcatactt tcaaatttct tattcttcat
    18121 tatttccata ggcaataaaa atgctataaa taatcctaaa agtccaaatg tatattgatt
    18181 tattggactt aaatcaggta aaaagcttat gtaattcttc aagacagaaa ctatagttac
    18241 taatgagcct acaaatacca ttggcaaaac tttcattata gttgattgaa ctgattgtac
    18301 ccatatattc ttagtcatat tatttacaac aggagtaaat ttttcactta aaaaatctat
    18361 aaatttattc ataaacactc tccccataaa tattttattt gtttgatatt agttctagtg
    18421 cttcttccaa agcctttgca ccatctagtc ttccatatgc agttttagat atacatgcta
    18481 ctggaacgtt atattcatta gccttttgtt gaatttcttc cttcatataa tctaaatgtg
    18541 gtcctagtaa taaacaatct atttctgata aatacttatc tatctctgac tcacttctcg
    18601 cttttatatc tgcttctata ccttttttct ttgcactctt tctcatacta gttgccataa
    18661 aacctgtact tgctcctgaa ccacacgcca aaagcactct tatatttttc ataataatac
    18721 ctccaatatt tttatccatt aatttatttc ttaatgaact ttttatttta ttatgtttat
    18781 attgtactta ccaaataagt tcatttcaca taaatatatt tcctaataat aggaaatcag
    18841 ttactcttaa ttaaacatat taatatagta taatgtatct tataatacgt acattcaatt
    18901 atataattat catatcatcc agattttatt ttaaaactat gcgagggaat ctaatgaaaa
    18961 catctaaaaa agaactattt ttaaatttca taaaaacaca acatgattgg atagattcat
    19021 ctacattggc taattatctt aatgtctcaa cgcgttcaat tagaaaatat gtaaacgaaa
    19081 ttaattccaa tggtgaattt atattatcct ctaaaaaagg atataaagta aatctcaata
    19141 ataattgtca aaccaaggtt gatagttcag aaaatatatc acctgataac aggttaaatt
    19201 taattttaaa agaacttata gttaatagta atggaattaa tatatttgat ttaagtgaag
    19261 aattgtttgt tagcccagct actattgaag gagatatagt caaagctaat aaatttatag
    19321 gaagttataa tttaaagata aagcaatcga aatttttatt gaaactaatt ggaaatgagt
    19381 ctgcaaagcg caaattaatg agctctataa tatttaaaga aacgggaagt gattttttaa
    19441 gcttatttga tgtacaaaaa atatatcaag agtataattt gactaaacta aaagaaaata
    19501 taatatatat attaaaaaaa tacaatttgt ttataaatga gtatgctata aacaacatac
    19561 ttcttcattt aatgataact atagacagaa taaaaaagaa taactacata gaatctgtcg
    19621 aagtagtaaa ctacatagat aataataatg atataagtat ttcaagagat atatcaaatt
    19681 ttttagagtc tgaatacaat ataactttaa ctagtgcaga attatactac ttagtatttc
    19741 agttaacaaa caaaaccaca gtcttaaatt atcatgaaat ggatactaag tcattgccaa
    19801 attatataga tgaacatttt gttaaattaa ctaaaaaaat aattaaaaat gtatatgact
    19861 tatatcttat agatttatct gatgaggaat ttgttgtaaa atttactctt catgtaaaaa
    19921 atttaatcag tagagccaaa aataatcaag ttttaagaaa tcaaatacct caaaagttaa
    19981 aagattccta ccctttgata tatgatatat ctgtttatat ttgcaatcag attcaaactt
    20041 tagaaaatgt agatatagac gaagatgaaa tatcttatat atctcttcat gtaggttcat
    20101 tctttgatag acaaaaatta ttagaagata aagttctatg tgcattaatt actccaaatt
    20161 actatgattt acaattcaaa atagtaagag acctcgagaa gagatttaat gaatccatag
    20221 aaattattca gattttttca gatactcata atcttgattt tgacaataag gtagacatgg
    20281 ttattactac tttaccaatt aacaatagat gccctatacc ttttgtttat gtaaatcctt
    20341 acctaaatag aaaggattat gataatattc aaagtaaatt tactcaaatt aaagatagaa
    20401 aaaatatact tactgtacaa aatcatttag aaatgtactt tagtgaatct ttgtttatga
    20461 aaaatatata tttagatagt gctaaagatt atataaaatt tatgggaaat attctgtacg
    20521 aaaataaata tgtcaaaccc aattatatag atgatgttct tataagagaa aaaatgtctt
    20581 caactgcatt taataacaat gtagcaattc ctcatagcat gaaaatggat gctttaaaaa
    20641 ctggagtatg tttaattgtt aacgataaac cagttaaatg gggtgaggaa aaagttcaga
    20701 ttatagctat gatacctata aatgaaaaag aaaaagaaaa attcaattac atatttgaaa
    20761 gctttattga aatattatct gagtggaata atgttaaaga acttactaag gcagataact
    20821 atagtagttt tatgaataga atagcttatc ttattcaaaa tatctaaatc aattaattta
    20881 tttccaatat atgtttctta agttattaac ataaaataga taagctgtca cactaaaaag
    20941 tctaaattaa tatgtgacag ctttttacct aatatacctt gttttaatac tacatatttt
    21001 ttgactgttg tatactagtt ataagattga atatttgtgt tgttgtagct gtcatattct
    21061 cactagcagt tgctttatcc attgcttctt ctattgtcat agctctattt actatagaaa
    21121 aataagcatc tataccctct tcattacatt taactgcatc ttctgttgtg gctccagcca
    21181 aacctattac ttttacctca tatttttttg ccagttttgc aactcctatt ggagccttgc
    21241 ccatagcagt ttgattgtcc aatctacctt caccagttat gacaaaatct gcatctttta
    21301 actcttcctc taatttaatt tcttctaata ttatttttat tccagattct aattttgaat
    21361 ttaaaaatgc taaaaaagca aaacctaatc ctcctgctgc tcctgctcct tctacattag
    21421 ctacatcttt acttaagtaa tttttaacta ctttggaaaa atttctaagc ccattatcta
    21481 actcctcaat tatttctgat gttgcacctt tttgagaccc gtatatgtat gcagctccat
    21541 ttttcccaaa cagcggatta tttacatcac aggctatttt aaacttacat tcatctaatt
    21601 cctttaatct attttctatt tttatatgtc ttatttcatt taaaactttt ccacctaatc
    21661 ctactaactt gttattttta tcataaaact caaaccctaa ggcttgaagc atacctatcc
    21721 cagcatcatt agtagcactt ccacctatcc caactataaa atttctatag cctttattta
    21781 ttgcttcctt tattatttcc ccaacaccat aagttgtagt gtataaagga tttctaagtt
    21841 cagtcggaac caatgttaat cctgatgctt gagctatttc tattattgct gtacttgtat
    21901 tttttaataa tccatatgtt gcatccactt ttttagctat tggtccagta acttctatag
    21961 tctctttttt accattcatc ccttgaacta aagcatctac tgtcccttca ccaccatcag
    22021 caagtggcaa tatctttact tgcgcatctt ctttaacctt caatatcccc ttttttattg
    22081 catttcctgc ctctattgaa gataagcttc ctttcaaaga atctatagaa attaatattt
    22141 tcatacttat ctactccttt ttattactcc ttattttaaa catataattt tataagctta
    22201 atttatcttt tattttatac tctacatctc tctttgtata caacttatac cattaatatt
    22261 cttttatctt ataaaaaggg agtgtctcaa aataaatttc ttagttcatg agacactctt
    22321 ttgtataaaa tcaaatatat gtttattatt tcaacaatga taaggaggat tatctctatt
    22381 ttaagataat tcctttttag cactatctaa tcatttttag cactatttaa ccagtatagt
    22441 tttaacttgg ttcattaagc actctacatt tacagagtta ttatctattg atatagattc
    22501 taattctttt tcatttaggt taatccattt agctgtttta atatttttgt taaatactat
    22561 gttagctgat tttgtttctt ctttagaatt ataaaatcta actactaatg cctcttcttt
    22621 ttcagccttt tttacaacac ttaacacaag gtccttatta gtttccttaa gtaaactata
    22681 tgaataatct acttctattt ctgattgatt caatttcata gcattatatg gcattttatt
    22741 ataagtttgt atttttgtta aatactcttt agccatattt gcaacatttg cttctagtgt
    22801 agatttttca tgagtaacta ttgctaagtc tatttttata tctcctatca tttgagaatc
    22861 tggagtaggc aactttattc ctgatggacg acctgggcgt cttgccattt cttctttacc
    22921 taggaatcct acacttctaa ataatgttat agctattgtg tcaaattttt cccctactat
    22981 ttcaaactct cttgtactgt ttgtaagaac agctactcca tgctctttgt cagacaatcc
    23041 aacgaatgtt agcattggat atatagaatc tggtctttca ctccattctt cctgttgcca
    23101 aacttccata gcatcatcat acacacttct ctttatatgt ccaaactgat tatcagacac
    23161 agaaaacttt gaagctatat ttgttggtat ataagttcta accctacaat ctcttgcttg
    23221 gttatttatg ttgaatacta catctattat agctttatca tttggaacat ttataactat
    23281 atcaaagtca ataaatgaat ctgctctatt attttttcta gcttgtatat cttttggtac
    23341 ttttaatcta taatttatct ttatctcatt attaaatcta tttttcttta tagtggaatt
    23401 tgctactata ttatcgttaa atattaattt ctcatttgga agtggtgaaa aatcatactc
    23461 atctccttca tctcctccat tttccatcaa taatacattt tcaaaagttt tatttaattt
    23521 tttatcaaat atctttaatg tcccgttttc attaacttga atagtataaa agtcattatc
    23581 taccatgtca catacttcat aagctttttc taacatatgt tcaacttctt ttatcatata
    23641 cgccttatac cccattgcag gtattttatc tttaaagttt attgtatata ccataaatga
    23701 atcatagttt ccataatgaa caatttgacg gtctattaat cctgcatcta ttacttcttt
    23761 atgtaccact tcaaaatcca acttattatt atctttatca aatatttcaa atgctttcat
    23821 tttagttata acttgggtgc tcactatttc attcctatcg taaggcatta agttaaatgc
    23881 tactaactta tctaaagcca tttcacaact cattgcatca actattcttc ttttgtaaaa
    23941 tgttattaat tggtctactt tttcctcagc taagaaaaat ctattcatta tttcctggtg
    24001 aactttatct gaacaacaac atccaatgct gtcatgagca tgatttttca ttatttcttt
    24061 ccaaattaac tctattaatc catgatgata ttcaaatcct agagaatatg caatagaagc
    24121 tagtggctcc aatatgttag ttatctttga ttctattcta gcatttgctg attttatatc
    24181 cattcttgtt gagaatatac ttctatgaac cctcatatat ttcccatcta aaaattcccc
    24241 ttttattgta tctatatcct catttttttc tagctcttta aatatgtttt catatctact
    24301 taagaaaaat tttctctctg gataacattc ttttaattta tatataactt caaatatatt
    24361 cttttgaatt ggcatttggt catgtccatt tggaagtatt atatggtcag tagttgcacc
    24421 cttatcaaga accggtaaat atttatccat tcttgttctt agctcatctt cattcattgg
    24481 tagatatttt cctattgcat aacctaatgg aagtatttga accaaaacag aagacccatc
    24541 atcactcttc caattaaact ctgttttatt agttcctttt ctttcagaac atcctctcca
    24601 aaacattgag tattttatat caaacccatt tagtatttgt ggcatttgag cactttgacc
    24661 aaatgaatct ggtaaatatc ctattttcat atattctcca aattcatcac aatcttttat
    24721 tccatatagt aaatttctaa gtatggattc tccaccaact accatttcat cagtttgagt
    24781 ataccaagga cctattatta gccttccttc ttgaactaat ttttttattc tctccttaca
    24841 ttcaggctta actgctaaat aatcttctaa tatagcagtt tgaccatcca tcacataata
    24901 tggatagtta tgattatttt ctaacatatc cattatttct tccatattat ttacaagtaa
    24961 tattctagat tcctcagttg agaagtacca ttctctatcc caatgcatat gaggaactat
    25021 gtgtacattt tttttcattg cttatcctcc aaaacttatc tgataatatt ttctgtctaa
    25081 ttaaaaatcc aataaaaata ctactgagtt tacaaaattt tttaatattt attttatcac
    25141 tataattaaa cctttgattt aaatatctaa taacgtatct tttaatgtat ctttctttga
    25201 tttttttgtt tcctagttat tattaataat attgctgata ttatagctcc aagtactgcc
    25261 gcaaagaacc atattgatgc tataataaat cctgacatac ttccctctaa aagcgccaat
    25321 gagaatatcc ccgctccagg cacttgaaga cctatattga agaatgctac tatagaccca
    25381 gttatggctg aaccagctac caatgatggt ataacacgga ttgggtcctc tatcataaat
    25441 ggtattgcac cttcagttat tccagccaat cctaatatcc aagtttgctt tcctatttcc
    25501 ttttctgatt ctgaaaataa atctctgcct aaaacagtag ctattgtaac tccaaaagct
    25561 gaaaccatct taactgatgc aaatattgca taaggtataa aatttccact tgctattgct
    25621 cctattgcaa atgtataggc tgctttattt attggtccac ctaagtcaaa tgaaaccata
    25681 gctcctatta ttgcacctag tagtattgca tttactccag tcatcccatt taaccaattt
    25741 ataagaccat tgttaagtgc tgctacaggc tttcctacta caaataacat caataaacct
    25801 actaccaaag aaccaactac tggatatacc caaaaactta cgaatccagc taatgtgcct
    25861 ttggctggta tattcttctt taaaaatttt actatatagc cagtaagtaa acctcctaac
    25921 atacctccaa gaaatccact acctattaaa tcagctgcta gacctgctgc aaatcctggt
    25981 ccaagacctg gtttttcagc tagtgagtaa gacatatatg ctgataatac tggaaccatc
    26041 aatgtaccta acatacctcc agaaagcttt cttaattgcc ataaccaaga accttcttgg
    26101 ttgtatagtt cttgtagacc aaatgcttga gatgctaata ctgcaaatgc aagtatcata
    26161 cctcctgcca caataagtgg tattatatga gatactcctg taagtattgc tgattttaca
    26221 tcttttttcc atgatgattt ttcacaatat gatatatcag atgatttttc tatataatca
    26281 cctttacctt gtttttgtgc tacttctaaa gcttcgtata ttatttcttt tgctcttttt
    26341 agtggagctg ctactgacgt ttttatgttt ggcaaatgtt caaatctttc tgtattttta
    26401 ggtgctacat ctgttgcata tattattgca tctgcccttt ttattatatc tggtgtatga
    26461 gggtccacca taccattagc tccttgcttt tctacataca catccacacc gatttcttta
    26521 ccagctttaa ttaatgcttc tgctgacata tatgtatgtg ctatacctgc agggcatgct
    26581 gttattgcta atataatttt ttttgattca ttttgaatcc taatctcttc ttttatttgt
    26641 tctttctttt cttttatatc taagttatta aataactctt tcttagtttt tgaatttaac
    26701 aacatattca tataatcttc atttgacagt ctagtaacta actcagaaag tatttgtatg
    26761 tgtgtatttc caccttcatt ttctggtact gctattaaaa atattagctc tactttatta
    26821 tttgggtcta cgctttccca attttctatt ggtgtctcta aggtcatagc tgcaaatgaa
    26881 gcttctttaa ctgacttaga ttttccatga ggaattgcaa gccctctttc aaaacctgtt
    26941 ggagataaag tttctctgta cattacagct tctaaatatt cctcataaga tgttaacttg
    27001 ccttcataat atagctttct tgctaagaac tttattgcgt cttcctttgt ttttattttt
    27061 tgttttaaaa aaacaaggtt ttcatttgtg attttcttaa attccaaaat tacgccctcc
    27121 ttaaatcatt taatgctatg aatatagcat aaaataaatt atgaaaatgt ttttttgaaa
    27181 ttatacacac aatttcttct taaaaaataa agatttgtgt atttatacac aaatctctat
    27241 cttaaccagt attgctctat tattgctctc ataatcatca taattggaac cttatctgat
    27301 atattgtacc catttacttg tttaattgtt gaatagcaat ataaacttat atctgcaatt
    27361 tgttgcaatt gattttcaca tatatgtgtt agagctacta ccttacaacc cttattaact
    27421 gctgtctttg ctgcttctat aacttctttc gtttctccac ttaaactaag tgcaaaaaac
    27481 atatcttgtt cacctaattt ccctatatca tgaagtactt catgtctttg actatagtaa
    27541 gttatattat catgcccacc tctaatttct tttactaata tctcacataa aggaatgttt
    27601 tgacctattc cataaactat aatactccta gatttttgaa ttatatctgc tactttattt
    27661 attttttcat aatctattag ctctaatgtc ttttttatat ctgattcaaa accatttttt
    27721 ggctctttat cctcattttt taactcttct tttaaattat tttttagttg agagaaacca
    27781 tcatactcca tttttttaca tagcctaact atggtatttg ggacagtaaa aaatttatct
    27841 gctaaagatt gtattgataa ttttactatt tcttctttgt tttttctcat atattcaatt
    27901 atcatgtctt ctgtatctgt aaatttatac tcatattttt ttgctctttc ataaaattcc
    27961 atagtttctc ctccatctat tttattattc ataagtaaaa ttcaaaaata ttagctaaaa
    28021 ttttcgttaa tataattata atttaatatt tttaatttat taatgcatac tactcttttt
    28081 attatacata aaaaatgtgt acttcctata ttgatagaga tgattcaagt ttttattttg
    28141 atacatctct atcaatattt ttttagaaaa tacacatttt tttcaaatac ttatttttaa
    28201 ttaaaacttt aggtaatcta ttctttatat ataattatta gacttgaaaa tatctttaaa
    28261 atcaaccaat tcaatattat ttctttttaa ccacatttta acttccttat cacatagcat
    28321 tgcatgttca tatactctct cttgaataag agaagatgat tttataagac tataatctat
    28381 aaatcctgga tgagtaacca tcaatgttat atctttatct aaatttatat atttttcttc
    28441 aaataattta acaaaagatt tatttaactt gtaaaaatca ttctgaggat atttacttgg
    28501 catgctaata catgaatcca aataataggg acaacttggt ataccgtatt cttttgcagc
    28561 atcacacatt gctgatattg atacatcttc ttctatacca tgtatatcaa tatactcagg
    28621 caatttactc atatacaact tgtaagtttc aatttgagca caaacttctt catatacttc
    28681 ttcataatta aaaacctctt tacctgtcag tagttgcgtt cttcttattt tgctagaaac
    28741 aaattttcca ccttcatcta acaaattctt tatcttaata tgttctttgc aacaaggttc
    28801 tcctattact aaattaacat gtaaaccaaa acatacatca tcatttttta ccatttctat
    28861 agcttgtctt gaaaaaggca tattcaccat gattccagca cttgtaacaa taccgttctt
    28921 ataagaagat attatcccta gtgtaacacc ttctgaatat cctatatcat ctgccctaac
    28981 tactagtttc ttcattttat gcgtctgcct gctttctcaa ctcatcaagt tgcatttcca
    29041 tctcatcctt tactttaaca acatccgttc ctatgatgat ttgaactgat gtattactca
    29101 atttaattac ccctttggct cctgtttttt taatattatc atcattcaaa atagtagcat
    29161 ccttcacttc taaacgtaat ctcgtcatac aattattaag agtcactata ttttcataac
    29221 caccacaatt tttaattatc tgtttagcca tatatgaaaa attaccatga gaaagtttta
    29281 aattcttttc tttttcacta actttatcac ctatctctat ctcaacttca cgtcctggtg
    29341 tttgcacatt atcttttatt attatatatt taaatgttac ataatataat acaaagaata
    29401 caactcctac aggtataact aaccacgctt tatctccata actaaaactt aagacatagt
    29461 caattatact tgctccatta aatgaaccca agcgaacacc cagtaaatat agtacaactc
    29521 cacctagacc agaataaaaa gaatgaatta tatataactt tggagatgca aataaaaacg
    29581 aaaattctat tggttcagtt actgttgcca taaaagaagt caatgctcca gcggtcattg
    29641 caccttttac ttcttgcttc tttttatctt gtgctgtttt atatatagca taagaaatag
    29701 caggtattga aaacatcata attatgtaaa atcctgtcca gaagaatcct gcatttgggt
    29761 ctcctgccat aaatctagga atttctcctc ttataacttc tcctgttgat gttgtatatt
    29821 cacccatttc aaataatatg taagcattta aaacttgatg taacccagtt ggtattagtg
    29881 cacggttaca gaataaaaac aagaatattc ctattgcacc agctcctccc aaccaaaaac
    29941 caaattgatt cattgcagct tgtggatata tccataataa actaaatata tatgataaaa
    30001 ttaaagcaac cactggtgat agtgtaatta cacatttttc tcctgcaaag aagcttaaaa
    30061 atgctggaac tttaacttta tatgttttat tgtaagtcca tgctatacaa gctccaacaa
    30121 ttatcccacc aaatacacct gcatttaatg tatcattcaa taactctaaa tttgacttaa
    30181 atatcatata tgcaactacg gctgcaacca ttacacttgt cttgtcttta gactttgagt
    30241 aggcactagc tgctcctaat aaaaataagt agtccacatt tgaaaatact atattagata
    30301 tattagatat agctggcaca ttgagcatat ttggaccaaa taataatcct aatatacctg
    30361 ctgctggcat tacagctatt ggcactagca tagtctttcc taaaagtgac agttgttgca
    30421 tcattttgtt taagaacctc ttcatatcca atcccctttc tatttcggtt taattttttg
    30481 tgaaaacgat ttgttcacat tttatatttt aaatattata tttgtttaaa caaattgtca
    30541 atatttttta ttcattttat ttttatcatt taatttaaca tataaatcct tttaagtgta
    30601 ttgctatatc tagtctattt ttttaattca ttttttttat tttaaaaata tgtttaacca
    30661 tgtatttgaa acaacccaca aaataattct attttgtcct ttttatggtt gatatgattc
    30721 tattttcact atacatgtct aaacacattt gatataattt gttcatatca gttcaataat
    30781 attactaaag acctttaagg agggataggg gtatatggct aaaaataaat tttcagagat
    30841 atatgaagta ttgaaagagg aaatacttga tggtaaatat acaagtaata tgatgctgcc
    30901 tactgaactt caacttattg aaaggttttc atgtagcaga aacactgtac gtagagcaat
    30961 ttctcaatta aacacagaag gatatgttca aagtataaaa ggcaagggtg ttgtagtgtt
    31021 agaaaatagt tgttctaatg atttttttct aaatatgcac aatttcaaag gtgtagaatc
    31081 gattgtagaa gataaaaagg ttaatactgc tactagtgtt ctccacttca gcaaaatctt
    31141 aattgataat aagttatcta aaaagacagg ttttaaagtt ggtagtgaag tatattacct
    31201 tcacagacta agatatattg ataacatacc taaaattctc gacattaact attttctatg
    31261 tagtatagtt aaagaccttg atgtttctat agcacaaggc tctatttata aatatataga
    31321 agagtgtcta ggtacaaaaa ttgtttcatc cagaaagata tttaaaattg aaaaagctac
    31381 agagcttgag ttaaaaacgc tacctctaaa tgattataat tgtgttggtg ttattaaaaa
    31441 tagtgtatat actgatgatg gaaagctttt tgaatatact gaatcaaagc atacacctga
    31501 aacatttgta ttcatggatg ttactcaaag atattaaaaa aattatgttt aattaaacat
    31561 aattttttta cgtttagaca ctttatccca tactaacctc actattctat atacaattat
    31621 atgtttatac aaataattat ttattgtata ttttagcttt aatattagtt taacgcttga
    31681 caatttgttt aaacatatta taattaactt ataaattaca ggaggtatca agtatgaaaa
    31741 attggtggaa aaaagcaact gtctatcaaa tatatccaaa aagtttcaaa gatagcaaca
    31801 atgatggtat aggtgatata aatggtatta tagaaaaatt agattatctg tattctttag
    31861 gtgttgattt attatggttg actcctatgt acgtttctcc tcaaagagat aatggatatg
    31921 atatagaaga ttattataat atagacccaa aatatgggac aatgagtgac tttgaaaaac
    31981 tcttaaaaga agctcataaa agagacataa aaataatgat ggatatggtc ctaaaccata
    32041 catctactga acataaatgg tttaaagaat ctaaaaaaag caaagacaat ccatatcgtg
    32101 attattattt ctggaaagat gctaaacctg atggttctgt tcctaataac tggatatcca
    32161 gatttagtgg aactgcttgg aaatatgatg aaaccactaa ccaatattat ttacatttat
    32221 ttgaagaaac tcaagctgat ttaaattggg aaaatgaaaa ggttcgtgaa gaatgttaca
    32281 aaatactaga attttgggct gataaaggta ttgatggttt tcgtttagat gtagtcaacc
    32341 tactctccaa aacacctgga ttacctgatg accctataac aggaccaaaa ggagatggaa
    32401 gaactcacta cgctgatggt cctcgtatac acgaatattt acataatatg aatcaaaaag
    32461 ttttcaaacc taaaaatata gttactgtag gtgaaatgtc atctactaca cctgaagagt
    32521 gtatcaacta tactagagaa aatcgagaag aactatctat ggtttttagc ttccatcata
    32581 tgaaaacaga ttataaagga ggcgcaaaat ggactaatga aatgttctct ctggataaat
    32641 taaaaaaagc acaatctgac tttcaatata aaatgtatga aggaaaagga tggaatgctc
    32701 tattttactc taatcacgac caacctagag ctttatctag atttggagat gatagatttt
    32761 ttcgtcaaga aagtgctaag atgttagcca taacattatt tggtctacag ggtactacat
    32821 acatatatca aggtgaagaa ataggtatga caaatgccta ctttactaaa atagatgaat
    32881 atgatgatgc tgaaagtaag aatgcatact atcatatgat taaatctggt attgatgaaa
    32941 aggaggcatt gcttatactt caacaaaaat ccagagataa tgcccgtact cctatgcaat
    33001 gggataatac tatttataag gggttttcta atcataaacc gtggttaaaa gttaataatg
    33061 acaatattag tgtagaaaat gagcttaatg attctcgttc agtattttat acttatcaaa
    33121 gattaatcaa atatcgtaaa caatatgata tttttacaga aggtacttat agattgttag
    33181 atgaaaatca taaaaatcta tttgtttatg aaagagagta taaaaaccaa aatcttcttg
    33241 ttataagtaa ttttactcat gataatgtag tatataaatt acctgaaact tatttgaata
    33301 aattaaacta cacaatactt gaaaccaatt acactagaga tataattgaa aataaaatgg
    33361 aaataaaacc ttacgaaagt ataatgatat attataaata aagttattta tgtaaaaatc
    33421 ggtataacac cctggtgtta taccaatttt actaaattca aagtaatatt tatagaatat
    33481 ctatagatta caataattat ttgacttcta catcattata tttctttgaa tatactttag
    33541 tcatatagaa atatatagga actacaatta tcatcccacc taatccccaa actatcttca
    33601 taggttcatc aatacctgct tttatcagta ataatatact tataataact gcaaatattg
    33661 gtataattgc tcctccaggt attctaaaat ttacatcttt accagcatac ttctttctca
    33721 atattagtac agctaaacat gtaggaatat attgaataaa tctagataca acacttattt
    33781 gagataatgt tgtgaatgaa cccgaccatg ctattagtaa agttcctatg acagatacta
    33841 taattgctat ataaggagat ccatttttat tagtttttct tatagactta ggcattaatc
    33901 cttgttcaac caaagcagca gcagaccttg gtgtaaatat ggatgatgca atatttatac
    33961 ctccaacaga tactatagtt cctattgtaa ttatataccc acctatagga cctaacatct
    34021 taatggcagc atctgcaaca ggagtagctg accctgctaa gccattaccc aacaccccta
    34081 tacttattcc cagtataagc atatatatta ctgatactac aaacattacc attaccaatg
    34141 ctttaggtac atttttctta gggttctcca tatcttttgc tgcaacagct aaagattcaa
    34201 atcctgtaaa agcataaaat aaagttatag atactgctac aaaagctgat gacgcacttt
    34261 gacctttttg tattattaca aatggggtaa aattagaacc ctttataaag aataatccta
    34321 cagctataaa taaaactatt ggtaataatt ttcctatagt catgatatta tttaagtgct
    34381 tagattgttt cattcccata aaatttataa tcccaagccc tacaactaat ataccaatta
    34441 ttatattttt aataagtggt tctgctactt gtggccatac agatgatagt gttacagcaa
    34501 agaaatttgc catagtagcc caagcaatca tactaactat ccacttcata aatccaactt
    34561 caaatccaac aaaatctcca aatgcctctt ttgcataaag atagggccct ccatcagtat
    34621 caaaccaact acctgcttca gcaaaacata aagcaataga aacagctaaa agcatacaaa
    34681 aaactaatac taatatactt gctggaccta tatctgtata agcatcacca ggtaacccga
    34741 atatacctga ccctattatt gcattgattc ctaatagtac aatactccaa aaacctaact
    34801 taatgccttt ttccattgtt attcccccca aagccaactt aatatattta tattttttat
    34861 ttagatgctt ctttaactat tgccataaat atttttttca tattatcata atctctagtc
    34921 atcatttctg gatgccattg tatccctatt acaaactcac ttccttcctt ttctatagct
    34981 tcaattaaac cgtctttaga tgtagctgaa acaatatatc ccggtgctac tttgttgaca
    35041 actaagtgat gaaaactatt aactaaaact tctttttctc ctagtatttc atataatttt
    35101 gtcccctcct ttatctgtac tgtatgtgta ggtacattag atagatgttg ctgattgtgt
    35161 ttaatataag caccttcaat taaagataaa tcttgataca aactacctcc ttcagttaca
    35221 tttataattt gttctcctct acatatacct aaaactggtt ttttcatatc taaagcatgt
    35281 tttaataatt tcatatcaaa actatctctc tttggtgata ttgcccccaa cttattatga
    35341 ggttcttctt tccatatgag tggatttaca tcttgtcccc cagatagtat aagcgcatct
    35401 atattagata cctgctcctt tataatctca tcatcatata caatcggtac aatatatggt
    35461 atagctttac acataactac tgattgtata taatcattat ttacataagc cctttcatag
    35521 ccaggaaaca ttcctccttc atcaattagt aaattacctg atattcctat tattggatat
    35581 ttctttttag ccaatttctt caccccttaa cttatttgtg aacaataaaa aatgctactt
    35641 ctcttaaaga gcaagtagca taccaagatt ttatttattt gaacattata atttatttta
    35701 gaaatacttt ttttgaatac gagtaatata aataacttta tttacttata ttttatttta
    35761 atcctgttta gtttgacttt tttaaattgt tttaagtaca actaataggt aaaataggca
    35821 tttagatttt cctttttatc aacctattaa atactgttta atatattttt tccccttcta
    35881 tttaattcac ttccctttct accagattca catattatca aatccagctc ttttaacata
    35941 ttaagtattc ctcttacctc accttctgtt atattgtagc ctaattcatt tattgaatta
    36001 acaataccat ttctacctat atttttatta agattattgg cattttttaa acactccatt
    36061 actaacttta ctttctctat agatgttcta tcctttaata tgcttatttc tttactaaaa
    36121 tcttcagtta tatttaataa gttatgaggt aaatcattta ttaaaataac atcctcagaa
    36181 ctcataatgt taatatacat agcagtattt tttaattctc ttatattacc tggccattca
    36241 tatgcattaa taatgtcttg aacatcttga ctaattgctc tcttcctttt cataaaatgc
    36301 tttaacataa cttctatatc ttcttttcgc tctcttaaag gtggtatatt tatgggcaat
    36361 acatttatcc tatagtataa atctgctcta aatctatctc cttttatcat ttctaataaa
    36421 tttttatttg tagccgcaat tactctaaca tctatatcta ttacattttc tcctccaacc
    36481 ctcattactt gattctcttg taatactcta agtaatttgc tttgtaagta tataggcatg
    36541 tctcctattt catccaaaaa tatagttcca ttgttagcct gttcaaataa tcctttttta
    36601 cctcctttta aagctcctgt aaaagcacct tcttcatatc caaaaagttc actttcaagt
    36661 aaattttctg gcatagctgc acagtttatt gctataaatg gctgactatg tcttggtgat
    36721 gcattatgaa tagactgagc catgagttct tttcctgttc cactttctcc cgttataaga
    36781 attgtataat cagattcagc tattttcata cctaatttct tagttctttc catcttcgtt
    36841 gaaactgttt ttatatcatc aaaagtatat ctagcaactt gtcccttttc tctaagcttc
    36901 tttgataggt tttgctccaa ttttcttatg taagttattt cttgaataca aaaataatat
    36961 ccagtaaccc ttccaaaact ctctatatta tacttattta cgtttaagta cttattatta
    37021 aattttataa cttcatcatg tgccttactc aaactaaaaa tctttttaat attctcattc
    37081 tctaattcat ctatattttt ccctataata ttactttgaa tatctagtat atcccttaaa
    37141 ctattattac aaataattat gtttccctta tctgatacca ttgccatacc taagtttgat
    37201 aaatttatta tggaatttag ttcatctgct tttatagtaa gttctttgta tttagtattt
    37261 attcctgaat ataaactaat tatttcatct gtatacttaa ttagcctctc agtaatttct
    37321 ttatcatcca gtttgagttt tgctattatt tgaataaacg ttgaactatc aatataccta
    37381 tggcctaaat caataacttc ttctatatat tttggaacta aacttgactc tcctggcgtt
    37441 atagctatct taatatttct atattcttca ttgggattgt atggtataaa attcaaatga
    37501 tttattccta tattgtataa attagatatt gtttccaata cagtatgctt attatcgttt
    37561 actactaata catctattcc ttctggcaat gaaaataact tatatatatc cttttgcttt
    37621 atgctcctat ttatagttat tatctttgag acatcttcca catatttttt tatttttaat
    37681 actctatcat ctatcattac caatattatg tcatctttta ttaattcctt ctctgttatt
    37741 ttatttaaat aataattttt tatcattact ttatctttaa agatcatttc tagattttta
    37801 tttaagaaac attctaattt agacaaccca tcagttacta ctgctattgt tttcatttga
    37861 ttactccttt taaaatatac tctactcttt tataatatac atttgatttt cactttaata
    37921 acacaaaaaa ttgtacattt agtatactaa catattcctt tattagtttt atgtccataa
    37981 atatcatagt tgcaatatct atcatatttc ttaaacttct ataaagcaaa aattgtgcca
    38041 aattaataat tttcttaatt ttattctaaa gttcctcaat agtatttaca gacttagcac
    38101 ttatagctta taagtcttta tattattaat ctatttttat aggttaattg tacaaatcat
    38161 atatcacttt tacctattaa atgcattata aaaaattgta tttataaaca ctatttacta
    38221 ctcttctaag tacaaacagt atctacatac tataaccttt caccattaga ttctattact
    38281 tgtttatacc agtcaaaact ctttttctta atcctagaca agtctccact tccatcatca
    38341 tacttatcca cgtatataaa cccatatctc ttggccatct caccagtaga tgcacttact
    38401 aaatctatac atccccatgg agtatatcca aataaatcaa cgccatcttc tacagcttcc
    38461 ttcatttgct ctatatgtgc ttttaaatac tctatacgat agtcatcatt tatcactcca
    38521 ttagattctt ttttatcata agctcctaaa ccattttcaa ctaccatcat aggtattcta
    38581 tatctatcat aaatttcatt tagtgcatat ctaagccctt cagggtctat ttgccatccc
    38641 cattcactag acttaagata tggatttttc actccaccta atatgttgcc acttgtatta
    38701 tcttctttag aatcactact tacacatgta gacatataat aactaaatgt ataaaaatct
    38761 acacaacctt cttttaaaat ttctaaatct cctttttcca tttttatttc aatattattt
    38821 tctccaaaat atctattcat ataagttgga tattcgccac gcacttgtac atctccacag
    38881 aaataattca ttactctact atctctttga gttttaactg catcatctgg attacaagta
    38941 taaggataca ttgttgcaaa tatttgcata catccaactt gataatttga atctatttca
    39001 tgagctaact taacagcctt agcacttgct acaaattgat gatgtaaccc ttgaaaacga
    39061 agttgaggta tatctacttg gtttataaaa tctgtagtcc cttcatttaa tattccttgt
    39121 gataagtagc ctcccatagg cattgtagct gaatttattt cattaaatgt cagccaatat
    39181 tttacttttc ctttatatct tttaaatatt gtttcacagt aattcatata caagtctatt
    39241 acatctcttg aaacccatcc attgtatttc tctgttattg caaatggtat ttcatagtga
    39301 gatattgtta ttaatggttc tatattatat tttaaacatt catctatcac attttcataa
    39361 aatttaagtc ctgcttcatt tggttctttc tccattccag ttggaaatat tctagtccat
    39421 gctattgaaa atctaaatac cttaaatccc atttctgcaa ataaagctat atcttctttg
    39481 tatctgtgat aaaaatctat tgcttcatga cttggataaa atgttccttt ttctataact
    39541 ctcgttattc ttttacttac tttttgagaa cctccagtac acatatctga acaagaagga
    39601 cctttcccat ctaaattcca tgctccttca cattgatttg ctgctgttgc tccaccccat
    39661 aaaaaatctt ttctaagtgc cataattcta cctccaataa tttatttata gtaactttat
    39721 tttaaaataa aaatacatat atataattct taattaatag aactctcttt tacgctaaaa
    39781 cagttatcaa tttctgacta ttatttacat gcttttgtgt attttctaca atatccacat
    39841 aatcagaata attagtaaca actactggtg tttctaagca atatccttct tttgaaatac
    39901 tttctatgtc aaaagttatt aatgtctgac cttttttaat cttatcccct tgattaacaa
    39961 aagatttgaa atatttacct tccaactgaa tagtatttaa ccctatatgt atcaatagtt
    40021 cacaaccatt atcagatata attcctattg catgttttgt tggaaataaa gtcattacag
    40081 tcccatcaaa tggtgccact acttttcctt ctttaggtgt tattgctaca ccttttccca
    40141 atatacctgt tgaaaacgct gcatcttgta tctgctccaa agcctttact tcacctttta
    40201 ttgggctata tactacttct cttttgtttt tttctataac gccttgccca ttatcatctt
    40261 tagaaatttc tactatagca tcatctttcc aaaaaaataa tgttaaaaca aatcctacta
    40321 caatagctac tattattgct attatagttg cataaacacc tttcatatct ccagttgttg
    40381 gatttatata attaggtata ccaaatattc caagtccacc cattacataa ctttttacat
    40441 tcattatccc cattacagct cctgccacag caccacctac acaactatat atgaatggtg
    40501 tttttcttgg taaagttatt ccatatattg caggctctgt tacaccacat atccctgaaa
    40561 taactgcagg tatacacagc tcttttatct tcttatcttt taatttaaag tacattgctg
    40621 ctactactgc tgtttgtgca aaagatggta caaatgctcc cactaatatt gtgtcaaacc
    40681 ccatagtcat aaggtttgac atagctattg gtactaatcc ccaatgtaga ccaaatatta
    40741 caagcacttg ccacaataaa ccagttaatg caccacataa aattggtgaa aagttaaata
    40801 aagctaaaaa tccatttcca actatattag aagcataggt agctataggc cctataacca
    40861 taaatcccaa tggtaaagaa actaataaaa ctgccattgg tacaaagaaa ttctttacta
    40921 catctggtat tattttagca aacactttct ccaacttagc tactaataat actattaaaa
    40981 ttactggtac tactgttgaa gtgtagttca ttgctattac tggtaatcct aagaaagtta
    41041 tatatactgg tgattcaaat attgttccag taaatagatt gtataaaggt tgacctgtag
    41101 atgctagagt atctaattga atacctgaat agcataaaac tgcacctata agcattccaa
    41161 taaatggttt taatttgaat ttcttagcag ctgtatatcc aagaattatt ggcatatact
    41221 ggaacattgc atctccaatt gcatttaaca taatatatgc accatcagtt tctccataca
    41281 aacccaatgc tgtaaatact gcattaaatc cttttatcat accagcagca cacagaactc
    41341 ctaatattgg ttgaaaaact cctgatatta tgtctataaa cttattaagt aatccttttg
    41401 gcgcatctga gtctgaatta tctattgtat ctcctcctaa tccagccaaa tcgcacacaa
    41461 cttcataaac atctggaaca tgattaccaa taactacttg gtattgacct gcacttttca
    41521 ttacagtaac tataccatcc atttttttta gcacatcatc atttgctatt gactcatctt
    41581 ttaatttaaa acgtagcctc gttatacagt gagataaact gctaatatta tcctttcctc
    41641 ctacattcgc aatgatttct tttgatagtt gttcatactt tctcattttt tctcctccat
    41701 tttctttttg aaatatgaag gtttggccaa cttaatgtca ccacccaata tatataaacc
    41761 taattattag gatttatatc tgacttaata cttttactta ccactctttc aacgtgaata
    41821 gttaagtata atttttcctc atctgttaaa tcgtagttgt attttttatg tataaattca
    41881 tccaactttt ctatgaattt ataagcattt ttatatttaa cttttattac atttaataaa
    41941 tcatcttcat tattttcatg taaattatta ctaacaattc gttctgcaaa atactttaag
    42001 tgagtaataa atctatgata ataaactgaa tcttcatcaa atactattct gtaatggtat
    42061 ttaaccatat ttgaaatttc ttgtattatt tgtgtaatct catatatagt ttttatactt
    42121 tgatccattt gtgcattaac tatatgcagt gctataaatc cagcttcatc ttctgatagt
    42181 ctaatttcaa attttttttc tatataatcc aatgcctcta accctatttt aaattcactc
    42241 ttataaaatc tttttatatc ccaaagtaat acatttttta cacttactcc ttcacgagct
    42301 ctttctattg cagtatacat atggtctgtt aaagaaatat aaatactatc atttaatctt
    42361 ttccctagtt tttctttagc atataaaatt atttcatctg ataattccat atatcttata
    42421 ggaatatctg ctattagttc tttaaattta tcagatatat ttgggtctga aagtttgaat
    42481 atcttatcaa ttttatcctt tgatatatgc tctcctgtac gttttttata agctaaacct
    42541 ctccccataa ctactatttc cttatgattt tcatcagttg taataattac attattattg
    42601 agtatttttt caataatcat tgtgatgccc cctttattag cattaagtta aaataaatct
    42661 tttttaatta tttagaatat ttaaaatgta atttattaca taaaaaaaaa cctatttatt
    42721 acacattaaa tagactccca tgagtcctga gtaataaata ggtttagctt gtatttaaac
    42781 aatcactatc cgtttgtatt ttattttaat tattatttat tatatgttag caaatttatt
    42841 ttttagtgtc aactttttct caatatttta attttaaata aattatataa attgaatctt
    42901 caaagtaata tttttatcaa taaacaaaat aaaaaaggta ttactttctt taagtaatac
    42961 ccatttattt ttaatttaag tggtttttct taatctcatc aagtagtcca tcttctaaat
    43021 aaatttctaa tgcacatcct accattgcct ttactgcttt gtgaagttta tcataagctt
    43081 cctcagaatt tgcataattt agaaattctt tttcatgaac atataccatt ggacttatat
    43141 ctaaggctat ttctgtatac atagtagggc aaacttgact tacattacct atatctgtag
    43201 aacctactgg accatcttta ccttctaata tatctgttat acctgcctca atcaaattat
    43261 tctttgttat cttttgaagt actttgttat ttattatgtt gtcaaaagaa ttttcaaagt
    43321 atctataaga aagcttagct cctgtcatta actctgcacc ttttgcacag tttataactt
    43381 ttttagttac ttcatctaaa taacttcttt cagcagctct tacgaaaaac ttacaggctg
    43441 ctttttctgg aactatattt ggagcctctc ctccatttga aactatacca tgtattctaa
    43501 catctgattt tacatgttgt cttagtgcat ttatcccagc aaaagtaagt tgtactgcat
    43561 ctagtgcatt aactcccata tgagggtgac tagctgcatg tgctgatacc ccttcaaaac
    43621 taaactctaa tgaatctatc gccaaagcct tacagtttat attattaaaa gcttctatat
    43681 gcatttgata acttacatca acatcatcaa aagctcctgc cttaactaaa tcacattttc
    43741 ctcctgttgt ttcttcagct ggtgttccta ttagtacaat ttttccttta aaattttctt
    43801 ttaacttact taatactata caagctccta gtgtagatgc tgcaatccag ttatgtccac
    43861 aagcatgagc tggttcttta ttttctccat atccaggaag tgcatcatac tcagctaaaa
    43921 atgctatggt aggtccatca ttatctccta attcagctct aaaagcagtc tccatattac
    43981 aatatggata aactgtatca aatccatatt ccttcatttt ttctactaag tattttgatg
    44041 atatgtattc ttcttcccct aattcaggat tgttaaatat aaaattacaa acttcttcaa
    44101 tttcttttcc aagtccattc tctatctcat aagctctctt ctttatactc tctatcataa
    44161 tttacctcct actagaatcc tagatataat cctattgtca aaaatgccat tacaagaatt
    44221 gttaatacta ccattaaagg aattacgaat ctaacccact ttgaccaagg aatattggct
    44281 actgctagtg ctcccattaa aacacctgat gtaggtgtta tcaagttagt tacacctata
    44341 ccaaattgat aagctgtaac tatcatttgt cttgatacat ctactaagtc gccaagtggt
    44401 gcaagtacag gtattgtaag tgatgcaagc cctgatgctg atggtattaa aaatgctatt
    44461 aatccttcta ttaagaaagt taaatttata aatatagttt ttggtaatcc atttaataaa
    44521 tttgctgcag aatttaaaat tgtatctatt ataaatccat tttctgctat tattacgatt
    44581 ccacgtgcaa atgctataca caatcctgct gtaattaaat ctcctgctcc acttataaat
    44641 gaattaacta tctcatcttg tttaagccct gatgctattc ctgatattat acctatagct
    44701 gtaaatatca ttgcaatttc agttatgtac cattctagtc ttaaaactcc atatatcata
    44761 atcgccatac ctattgtgaa aatggctatt accatggctt ctctttttgt aaattccttt
    44821 atatttgtat cactattaac cattaattct tgatttagtg atatatcatg tactaaagat
    44881 tttttagggt cttttttaac tttattggca tacatcataa caaatcctat agatatagcc
    44941 atatatatta taaacataac aactctaaac tctattccag aacctggtac tatttgtgat
    45001 aatgcttgtg ctattcctac agagaaagga ttcgtagtag ctgctccaaa tccagctgtt
    45061 gctcctataa atactgtggc cactgctgtc aatgaatcat atcccatact ggtcataagt
    45121 ggaataaata tcatataaaa aggtagtgtc tcttcactca ttccaaacgt cgtcccacct
    45181 agtccaaata gaatcattga aatcggtatt attaaaaatt gaaacttctt cattttattt
    45241 acagtatgag ctataacagc ttctatagct cctgttttat taactatccc aaaagctcct
    45301 ccaactatta aaacaaatcc aactacttca gctgcatcta taaacccgtt tataggtgct
    45361 gtaaatacat cagtaattcc ttgtggattt gatggtgctt tttcataagt tccagctaca
    45421 acaactgacc ttccgtctat atctactctt tcaaaatttc cacttggcac tatccaagta
    45481 agaattgcca ttaacactat tagcaaaaat attattgtaa gtgtctgtgg catagtaaac
    45541 tttttctttt ttaaactgct catttttaat ctccccactt tttaaattaa atattttatt
    45601 attgcatccc tttatcctat tttgtataga tgtaaaaaag ctcaacatgg atacatgttg
    45661 agctaaatgt gctaaataca acatacctgc atcttccctt tatcttgttt aagatagctc
    45721 tccatcaaaa ttcgggataa ttttgatgac agtactgtac ctattaaata cagtcccagc
    45781 actagcttcg gacactagca cttcggcact tactcctttt atattgcctc attggtttcc
    45841 aacctcttca atattaatct tagtaaatgc aacctctacc tcaatctgtt tgttagatga
    45901 ggtaattctt attaattttt attaattcaa agtaattgta gcataatatg tcgagattgt
    45961 aaatattttc agtataataa ttcttacttt atgatttcat tccatttttc acaaataatt
    46021 ttttctccat ataatttaaa tactgtagta tattttaaat acacacaaac tttccacaaa
    46081 ttttaaatta ttataatacc tttataataa aaaataaaag ctatgtaaac ttatcaattt
    46141 acatagcttt atatacatta atctactcca agtacagctt taagctttga tgctattgta
    46201 ataactcgtg gaccaaatat aacttgaact gagtttttct ttttaacaac tccacttgca
    46261 cccaattcat ttacccagaa gccatcttca tagaatccat caattgaatt tagctctacc
    46321 ctaagtctag ttgcacagtt tgtaacattt tttatattat tacttcctcc taaaccttct
    46381 attatagaat gtacaagctt tgtatcttta tcatctactt cctcttctac tgcattgttg
    46441 tatgctgttt taccagcatc tacagattgt ctttctctat attctttctt actataaagc
    46501 ttaacttctt ctgagcttct tcctggtgtt tttatatcaa acttcttgat tgcccatgta
    46561 aatattatat aagtaactat aaaaaatatt ggtatcaaaa ataataatgg taacgcatcc
    46621 actttttgtg gttgtaataa attaggaaac atatttctaa atgattctcc cattatagaa
    46681 acattaaaca tttctgtaaa tacatacgtc aatcctgcca gtggtacata tgctacaaaa
    46741 tataataatg gtgcaacaaa taggaatgta tactctattg gttccgttac ccctaccaac
    46801 atggctgtta ctattgctgg tatcaatata cttattgctt ttttcttatt agcattatca
    46861 gccaacttat acatagctaa agctgctgct ggtaatattg caaaatgtat taataaacga
    46921 cctgttgtga agttacgagt tatataagat agtgtatctg ggtctcccat ttgagctaat
    46981 cttatattat taacaccctc gtaaattgct ccacctactt ccattgttcc acctactctt
    47041 gtatattcta tagggaatgc aattaagtga tgtataccaa atggtaataa tgctttatcc
    47101 attgctccaa aagtaaatgt tcctaataat ccactagaac ctatccaatt accaagttta
    47161 gataatgcca accctactgg tggccatata aagtacattg ctgtacctaa tactattgat
    47221 gctataaaca tcataatcat tgaaaatctt ggacctgaga aaaaagataa tgcactagga
    47281 agttctatgt caacaaattt gttatgtact gcactagcta caaatccagc tattatagct
    47341 ccaaatatac tacaatcata tgaaaagatt cctaagaaag aaccatataa agaacttcga
    47401 ctatatgctt ctgcctctcc taatccagat gccataaacg cttctgctgt aactgtatct
    47461 gaatttatac catttgctgc taacaatgta cttataactg tgtgcattcc tataaataaa
    47521 acaattcctc ctaatgcacc ccatcctttt tcctttttag ataatccaaa ggctatacct
    47581 gtaacaaaga atattggtaa gtatctcatt accataaatc ctaaatcgtt tattacttta
    47641 aagaatacat ttataaatga cccttctttt attagtccgc taagccctaa tgcagaaacg
    47701 ttttccatat ttgcaaaagc tgaccctaat cctataaata ctcctgctac aacaagtaat
    47761 ataacaggta tcatcattgc tccagaaagt acttgtaatt tatccttcat agtattattt
    47821 cctccatttt tattgaaatg ccaggctata taatgcatat atatatactt ctattgcttt
    47881 gtataatgta tctatactta tattttcatt tgcctgatgt gaatttggat tatccccctc
    47941 tattgtgggt ccaaatgcaa ctccattttt taacactctt gcataagatg cagctccttt
    48001 tgtaaaaagt tcagcttctt ttccaaaacc ttgtttatat gcatttgata atttatttat
    48061 taattcacta tctggtttta catacagtaa ttttaaatcc ttatatatat caactattaa
    48121 attttctttt tttccaattt cattaattct attagttata aactcccaac ttataccctt
    48181 aggatatcta aagtctattt tcatattcaa ttcatttttc tctaagaaga tactcattat
    48241 acatattgta gaaaccccca tatctacatc ttctttatat atccctaatt tttttccatg
    48301 attatcatct gtaaagtatg aatttaaaat atcccttatt ataacgcctt tatcatttag
    48361 ttttttaatt ttctctaaat cttttgctaa actaaatgca cagttatatg acctgtgtgg
    48421 atttctcgat aaagcccttt ctcctgtata tcttactaat actttacctt cttctagttc
    48481 ttctatctct gtataataag ctaatgattc tactaaatct ttcttatcat tagttttaaa
    48541 aacagcctca attttgttac atacaaatcc atcttctttg tttgacttta tatcaactaa
    48601 attgtgattt ctaaatttat ctttatctat tttctttctt agattgaagt ataaaatacc
    48661 tttttctcca tttactattg ggaagtttcc atctggagaa aatgcaaatt ttggctgttc
    48721 attgacacta aagtaatgct ccatacattc ccaagtcgtc tcttcagctc cacccactat
    48781 caatctaatc tttctcttcg gcttttcatt aagttctctt aagaaaagta atgcatataa
    48841 aatccctatc aaaggtcctt tgttgtcatt aactcctcta ccataaagat agttatcttt
    48901 ttgacatact ttaaaaggtt tactcttcca aagttcttta ttatatattg gcaccacatc
    48961 tatatgatta agcaccccta ctacttcttc tccttctcca tattctatat gaattgcata
    49021 tccatcaaag tcttttacaa caaaatcttt gtcttttgct atttgaataa gcttatcgaa
    49081 ggcatttctt atttctatcc caaatggttg atttatatct gttgtacttt catctctaat
    49141 tgaaggtatt tcaactaaac ttctaatatc atttatgata ttttcttgat tggattttaa
    49201 ataatcaata attagttctt tgtttactat catcttaatt atttatcacc cctttatatt
    49261 aattttacaa agcatttcag ttcatatcta cattataaat tttgaatatt attttttcaa
    49321 tatttcaaat acttctctaa gttaccataa tgatacggta aacaatcaac agattatgac
    49381 aaaatcatac tatacctatt actaatattt taacttatct attacgtctt ttttaatgta
    49441 agtttattcc aaaaatacat aaaaaaagat gtagccttag ctacatcttc ttatatctat
    49501 tcaacttcca ttattatgct attaatatct acatttccag gttctatcct atcttttact
    49561 gttctcttaa cagaatcagc atcatccatt ataactacag gagttattat atttaaatca
    49621 tttgacgtta taaaatctaa atctacttcc attattaaat ctttagcttt taccttatct
    49681 cctgccttta ccttaacatc aaacggcttt ccttctagtg acattgtctc taaacctaca
    49741 tgtattaata tatttgtatt atcattactc ttaatcatta ttgcatgctt tgtatcaaat
    49801 acattgacta tttcaccatc aacaggagaa tataacttac cttcacttgg tattattgct
    49861 actccatctc ccatcatctt ttgggcaaaa actgcatctg gaacatcttc taagttcact
    49921 aaatttccct taaaagggct atatattttc tcaatcttat tttctttttt cttaaatata
    49981 ttaaacataa cacactctcc acattataaa attttatgat aatatttttc ttaaagcttt
    50041 tgctacacca tcatttacat tagtatcagt tacaaaatct gccatagatt ttacttcatc
    50101 tgtagcattt cccatagcaa taccaagacc tgcaaattta atcatggata tatcattttc
    50161 attatcacct atacaaataa cttcttcgct atctatacct aatatatcac aaaatttttt
    50221 aactgcaata ccttttgaag tacctttgct cataacttca aaatttatct ttccagaact
    50281 tactacttct aaatcttctt gttttttaaa ttcttccttt gcttctctca aagaatctac
    50341 gttttctgag aaaagtatac attttaaaat ttcattatca gctttttcta ataaagtttc
    50401 acaacttgca ttttctatta tttcaattct gtcttcttct ttatttttac tatttattaa
    50461 tctatatgga tgttcttcac ctatttcatt gttggatata actattttac agcctttaaa
    50521 atgtttgttt aaattatact tttcacctat tgtatagatt ttctttagag tttctttgct
    50581 caaaaccttc ttatactcat atcccagtaa tttaaaatat gtcccattag ttgatataat
    50641 atatatatca tcccctaaaa cacttgtaaa atatttcata gcattataag gtcttcccgt
    50701 aactaaggct accttgatac ccttttccat gacttctttt agtgctttaa tattttcttc
    50761 tgatacttca aatcctttac ccatcaaagt accatccata tcagtacaaa ttaatttata
    50821 tcgcatttgt atcacatcct agtaagattt ttctaatatt tcaacaaggt cttctttctt
    50881 tccaaaaggt aaaaatccta aaactggaca gcttgttatt tgttctaatt gttcctttgt
    50941 tacattaaac tcagacattt ttgtcttaag tcccactctc tttaaaaaac tttctatttc
    51001 atttcctaaa gttttagctg cttcatcatc ttccactttt tctaattctt ggtttagcat
    51061 tctcgctact ttggcaaatt tctctatatt atccttatag aacttttctg caaattttgg
    51121 gaacactata gccaaagcct caccatgagg aatatgtgta actcctccta ttatttcact
    51181 tagtggatgt ggtgctgctg ctccagcatt tgccagtgaa cttcctccta atgtatctgc
    51241 tactgctaac tttgttctgt attctatatt atttttatct tccattactt taggtagata
    51301 gttaatgact aattccatag atttttcaga cattatctct gtaaaatcat tagcatttgg
    51361 atttatataa ctttcaaatg catgggtaaa agcatcaaat gctgttgatg cagtaattct
    51421 ctctggcaga gttaacataa gctctgggtc aactatacat tcttttgaga aacaattttg
    51481 atgaaatatt gtatttttct cgcttcctct cgatattact gctgcttgtg taacttggct
    51541 tcctgttcca gaagtagttg atacagctat taacggtaat tctttttcac ttaccttatc
    51601 gtatatttta aatggatttg tatatgtact aaacatataa tcccaatcta tcttttctaa
    51661 accaaaagtc aatgctaata cttttgcagt atctatactt gaacctcctc caacagctaa
    51721 aacaacatct acagattctt ttttagctaa ttcaaaccct tcatttatta attctacagt
    51781 tgggtttggc tctactctat caaagtgtac aacttctata cctttttcta ttaaattcaa
    51841 tgtaactctt ttatataact tgtctaatgg ctctacattt ggagtagtaa ctaacaaaca
    51901 tttctttcca tattttccta ttattctagg taattcactt aaagttcctt gtccaaaatt
    51961 tattcttgat ggttgataaa agttaatcat atttttcctc ccttaaatta ttgccttcat
    52021 attcaaatta tacatatcat aggattttta aggcaatacc ttcactgtta actcttattt
    52081 actaaagctt atggcaatta ttagacaata aatgttttat tattaccata tcattatgta
    52141 aattttatta agtacccatg ttataatttt ataatcaatc ttattgtata attgacttaa
    52201 taataaaaat agagtatata cactttttta tgacaaatag cttaaaggag aattaaatta
    52261 tgaaatattt gatagacagt gctaatcttg atgaaattca aaagtgttta aagtatggat
    52321 ttaagggaat aacagctaat ccatctatgt atcttaaaga gaaagtaaac ttccatgaat
    52381 ttattgagac atgtgctaat ttaaatccag aaatattaac tgctgaagtc attggaaata
    52441 atttatacga attaattaat tcatgtgata agatattaaa tataaataaa aacactataa
    52501 taaaaataaa tttctctgaa gttggcttag aacttataaa catattaaat agtaaaggtg
    52561 taaaaactgc atgtaccttg attttcaatg taaatcaagc atcattagct ataaatgcag
    52621 gtgctgatta cctattccct tttataggta gaaatgatga aaatgggaat gatggtataa
    52681 aaaaccttac agaaatatgt aaccttatat caataaatgg atataatact aaagttgttg
    52741 cagcttctat taaaaatgta ttccacttaa ctcaagcatc tctttgtgga tgtgattatg
    52801 cagctgtaac atatgattta tttaaaaaag cttcttttaa ccagcttaca atagatggtg
    52861 ccaatacttt tgaaagagat tggtccaagg ttaataaata gtaactaaga tttaggaggg
    52921 tttgcattga acaaaagatt attagatatt gctgaattat tactcaacag ctcagactat
    52981 attactgtag atactattgc cgaagaatta aaagttagta ataaaactat tcgtaatgac
    53041 cttgttattt tagatgaatg gcttttagag tttaatttat ccctagataa aaaaactggt
    53101 tcaggggtta ttattctagg taatgaagat ataaaactta aagttattag agatatcaat
    53161 gataaatcaa attgtatata tgcatactct cctgaagata gaaaaaggta tattctaagt
    53221 aaattattta ttaaaaattc taagtttagg attcgtgata tttgcaatga actacatgtt
    53281 agtagagcta ctgtgcataa agacttggta gttattcaaa attttttgca aaactttaaa
    53341 gtgactctag ttagaaaaac caataatgga gtatatttag agggaaaaga gaaagatatt
    53401 cgaaaagcaa tttttgaact tgctactgtt aataaaagtt atactgaact taaagaaata
    53461 ttattctcga aatctaatga atgcaaagat accccatcaa caaaaatatt taaggagcta
    53521 tttaactatg attttgagaa attatctcaa atcactctac acaccttaca agtagaaaaa
    53581 agtaacctta gtgatgagta ttatataaac ttcttaatac atatagctat atgtattaaa
    53641 agaatttcaa ttaaaagata tattaactta tctgaaggtt tttttagaga attattagaa
    53701 catgaatact ttgaaaaatc aaaaatttta tgtgctaacc taagtgaagc ttttgacgta
    53761 gaatttattg atgaagaggt ctgttacatc cttcttcata tagaaggatt acttaaatca
    53821 ataaagaaaa ctactactct tgaacctctt aaaaatgaag aaattacaga gtataatcta
    53881 tctgaagcaa tagctgttca ttggggaagt atactaaatt taaacttaaa ggacgattta
    53941 atattaataa agtctcttgc taatcacctt aaatcagttc tacacagaat aaactatggg
    54001 tttactatta caaatcccat attaaatgat ataaagagaa catttcctta tacttataag
    54061 gctgctaaag agtctaatac tgttatcaaa cagttgatga attatgaagt caatgatgac
    54121 gaaataggat atcttgcttt atatttaata tcagcaatag atagaagcaa atctccccta
    54181 aatactattt taatatgtca ctgtagtgat ggtgtatcta atttattagt ccaaaagtta
    54241 agttttgaat ttaatcagat taatatagtt aaatctatac ctctatcttc tatttcattt
    54301 acgaactttg atgatgtgga cttaatacta actactgctc ctgtagactt tgaacataat
    54361 gctgaactga taaatataaa tgctctttta agtaagaatg atatttctag acttagtaca
    54421 attataaaaa aactatattc tgaaaaaaat aaaatattat cttataaata aacaaaaata
    54481 ggcttgtctc aacatagaga taaacctatt tttcattgtc caaatgataa aaatatattt
    54541 gatttcatag aaaaagtgcc tcatgaacta aaaaattcat tttgagacac cttcattttt
    54601 tatatttaat ctttttattt aagcttttat attttttaaa cttttatatt taaagtaaat
    54661 tttattattt ttattgagca caagcattat ttatattatt aatttcttca gtattcttac
    54721 caaactttgt agttacaaat cctattgttt ttattatgag taataaggat atcaatgaat
    54781 atatagatat cataaaattc ttacttatta ttccagacgc tactattata aatccatcta
    54841 gcataaataa tataactggc aacttcagaa acttaattac cttattaata agcattgcaa
    54901 ctaaatcagt tccaccagta ctacagcccc ttattattgc tatccctata gcagttccta
    54961 ccaataaccc acctatcact cctgctacta atagattgtc agttatgtga gtttgtggta
    55021 ttacttttaa gaataatggg cccataagag ttatatataa tgtttttatt ccaaaacctt
    55081 tccctaaaaa taataatccc attactaaaa gtggcataga tattcctaat gatatattct
    55141 caacaggcat tgataagaat gtgctaagta cgactgataa tcctgttata cctcctggag
    55201 ctaatgtatg ttctgcaaag aaaaaattaa ctgctaatgc cattaaaaat gctgatattg
    55261 ttatcagtaa ataatctttt atcatttctt ttttcattta ataacctcct atgattatat
    55321 tgtttcagta taaaaaatca attaaattag tctagcttcc tgtagttttt cataaaatta
    55381 atgcttcctt aaaacattaa gaaagcatct cttttatcat agtttattat cttattctaa
    55441 accaaacttt gtagctgctt catctatagc ttttctacaa ttcttaacac ctgctgttat
    55501 accatcttta tccttgaata ttgctgaaga taatattaca acgtctgggt tacattctat
    55561 taatggctcc atattgtctg atcttagtcc accatctatt gctaattcac acttaggatt
    55621 cttttcgtct atcatttttc tagctctttt tactaaatca acagcactct ttctccatcc
    55681 ccagttatct tttccatcag tttcatcaac accatgaacg actatttgca atctgtctat
    55741 atcatatata gcttcatcaa caaaacataa tggtgtgtaa catccaattg ttaatcctac
    55801 tttcatacca aattctctac agtaatttat tatgtatgca agaggagcac ctaaaaaatg
    55861 ttctgctggt attatcaaca agttacatcc tgctgctgct attttttcta taaataatct
    55921 atcacaatct cttgtgtata tatggcattc tattggttta tctgtcactg gtcttattgc
    55981 ttctattatt tgatgaccac ccataagttg catatttttt aagtcatgca tatctgctgc
    56041 atctgaatgt acgtagtcta cacctgcatc cattgcttct ttaactacgg ctgatatatg
    56101 accgtaattt acatgtgcta atcctgctgc tatttttatg tgtttcatat ttgtatacct
    56161 ccatatttta ctttaattag tattaaatat tagtttttga tattttttta atatttttta
    56221 atccagtatt acttttattt agcattactt ttattgctgt atatatttct tttatgaact
    56281 tattctgctt ttgttaactg tgaacttatt ttgctttgta aattaatatt acactgatat
    56341 attttttttc acaacacttt gactactcct taaaagtacc tttatattgt ggtaaattat
    56401 agacattaat tgtatataaa aagttagttt tttaccacat tcttatggca tttattgtct
    56461 atactaactc aattgatata gctagttcat ttaatatata atcagactat aaatataaat
    56521 ttactcgata aaaagtacca ttcataacaa tattaatgaa agggagatgt aaaatgagaa
    56581 actgtattat tgcccaatct ggaggcccta cagctgttat caatgcttct gcagttggta
    56641 tttatgaaaa aaatttagaa actaaatact ttgataaagt atattttggt atcaatggga
    56701 ttgaaggtat attaaacaaa aatataatag attcagactc cttaaacaaa gataatgtat
    56761 taaatttaaa gcaaacacct tcgtctggtc ttggttcttg tagatacaaa ctggctgatt
    56821 ataaaataaa ttcttatgat tatgatagag ttataaatat actagatgaa tataaaatag
    56881 atacattatt ttatataggc ggaaatgatt ctatggacac agtgatgaaa ttttctcaat
    56941 actgcaaaaa cactacttgt aaaataaaat ttataggtat tcctaaaaca atagataatg
    57001 atttattagg aactgacaac tgtcctggat ttggttctgc tgcaaagctt atttctacac
    57061 taataatgga aacatactta gatttttcta tatacaaaaa taatggtata tttatagtag
    57121 aaactatggg tagagatact ggatggttag cagcttcttc ttcactagct agacttaatg
    57181 atactccact tgttgattta atataccttc cagaaattga tttctatgaa gataagttta
    57241 tagaagatgt tagaaaaata tttaaagaaa aaaataaggc ttatatagtt gcatcagaag
    57301 gtataaggga taaatacggc aactttatat gcgaacaaaa aacttctgct catgataaat
    57361 ttggtcattc ccaattaggt ggagtaagca actatctaaa gaatcttata gtatcatcat
    57421 caattacaac aagagtaaaa accttagaac ttggtgtaat acaaagatgt gctatgcatt
    57481 tagcttcaga tactgattta aaacaagcag ctgaagttgg tgcatatggg atagaactat
    57541 ctaaaaaagg atatacagga gttatggcta tcattaatag aacatgcaat aatccttata
    57601 agtatgaagt tagtcatact gatatttcta aaatagctaa caagacaaaa tattttccta
    57661 aagagtggat aaatgaagaa tgtaattata taactaatga agccctaaat tatctatatc
    57721 cacttattca aggtaaacca gatatcaaat ataaaaatgg actaccttat ttttcaatta
    57781 tttactagga aattattata atttgatata cactcaattc tatcgctctt aaatacctaa
    57841 gtggctgtta aataaaatta taaattgtta tatgacagtc acttaatcgt ttaattattt
    57901 aactgtttag ttttttaatt ttttaatctt tttaatacta atacaatttg ttgtaataat
    57961 atctcacacc cattttcatt ttggatagat tataattagt tagacaataa atattttgtc
    58021 atgatattat tatatatagt gatacaaata gaaatacttt tatcatggct agaaaaataa
    58081 agattacaca aaggatttaa aagtcaaaca acttcaatta aaataaatgg ttaaaataac
    58141 ttctaaatca actacataaa caataaaaga acataaagta gttaaatcta caattataaa
    58201 attagtaaga ctataataac ttaaataaaa ttaaagttaa caaagactat taaagttagc
    58261 aaatattcct ctacctaaat aattgctttt tataaagagt tatttatttt aattgaattt
    58321 aattgaaata cgattttaac tagaacaata gattaatgta atatttaata taaaataatt
    58381 ataataattg aaaaggaagt aatctatgat gaaaatagca gtcataacaa ccgaattttt
    58441 aaaagagttt gtagataatt ctataaaaaa gttaaatatt aatgcagaaa ttgaaatata
    58501 tatctataga gatttttctc atgttggaga tttatattta gaaatagaag ataggtttga
    58561 tggatttgca gttagtggcc ctatccccaa aaaagctatt acaaaaaagg ctggaactat
    58621 taaaaaacct ctagttgatt ttggtactga cttacaaagt tactatgata tgtttctaaa
    58681 gcttatcttt aaatataata cattagattt ttctagagca tactttgact taacagactg
    58741 ggcagataat ccaaaagata tatcatatta tttatcaaat ggcacatttg gagacttaat
    58801 ggatagtatt gatgaaaatg catctaaaat gagtttatct gacatagcaa aacttgaaaa
    58861 aaagattgca aaaaaacata ttaatctatg gaatgaaggg aaaatcgatt tttctactac
    58921 tcgttttagt agtattgttc ctatgttaca aaatgcagga gtaaactttc atttcatata
    58981 ccctgatata gatttattaa aaaatacttt taataactta ataaaagata ttcatttaca
    59041 tagaatgaag ggaaatcaac caagtgtaat atatataaca gttaaagata caaattatga
    59101 tgactctact ctagaccaag tttataaaat attaaatagt attaaaaaag ataaattaac
    59161 cgattttata attgaaaaaa atagtaattc ttttaaaatt ttcactaaat gtgaaacgat
    59221 taaatcatta actaaaaatt ttactgcatg ttatataaaa gaatctattg aaaatagtac
    59281 aaatattaaa gtatgtgttg gatatggaat tggtaatgat ataaagcaag ctatgtctag
    59341 tgccataagt gctaataagg aatctaaaat aaatcattta aattacagtt tcttagttaa
    59401 cgaaaattat gagacaatag gacctttact gtgtgataag ttacttactg tttcaaataa
    59461 agtaactcca catataaata caattgccaa aagttctaaa ttgtctactc ttactattca
    59521 aaagattata tctgttactg aaattctaca aagagatgaa gttactccta aggaattatc
    59581 ttcatgttta aatgtaacag ttagaactgc taatagattt ctaagtagtc tcttaaagtc
    59641 tggaaacgct actatattat atgaaaaaca aaactcaaca aaaggtagac ctgaaagggt
    59701 atacaaatta tttatatcag aaaataaata ttaaaatcca aaatgcataa aaatatttta
    59761 tcatctaata ttaagtaaaa ttatatatga ctttctaaaa ggtatatctt tgcatctttt
    59821 taagatatac cttttatgat atttaataat attttatgtt attatctact aaaattattt
    59881 tctaaccatt ttactgcaca atgagcaaat aaagctgaac cataaactaa tccctcttca
    59941 ttaaaaattg ctttaggatt atgcatacca aaattatatc cctgactaat acttcccatt
    60001 ccaatccata aaaatactcc tggaaccctt agtaaaatct ctgaaaaatc ttctgaaccc
    60061 attgcagatg gaaagtctat tacattttca tttcctataa cttctttaac ataagataca
    60121 atctcatctc ctacatccaa atcatttata actgcaggag tccccatttt aaattccact
    60181 ttagcatttc ctccaaatga tttagctatt cctgtagata tttcaataat tctatttttt
    60241 aatttttctc taacaaattg gtcaaatgtt cttaaagttc ctgacataga tgctttattt
    60301 ggtatagcat ttggtacgtt tcctgcatta aacataccaa tagttaaaac tacaggttct
    60361 ttctgaggtt tttctcttga aagtatagtg tttaatgcta tttgtatatg cgacattatg
    60421 tttattgggt ccactccaaa ttcagggctt gctccatgag ttgcttttcc ttctactgtt
    60481 atttcaaata tatccgcaga tgccatagct ggaccacgtg aataagctac ttgacctgtg
    60541 ttaagaaatt tacccaccat actgtgaaat gccatagctg catcgacctg aggattttct
    60601 aatataccat catcaatcat tgattttgca cctctggtag tctcttcatc tggttcaaat
    60661 acaaacttta ctctaccttt aagtaagtgt ttattatcca taagtatttt agctgctcct
    60721 aagagcattg ctgtgtgatt atcgtgtcca caactatgag atgcatcttt attcttactt
    60781 ttaaaaggta aatccgtctc ctccataata ggaagtgcat ccatatctgc ccttaataat
    60841 aaggtctttc caccattttc actgtctaaa acagctacta ttccattatt agacgtcaat
    60901 ttcggagaat atcccatttt ttctaaagta ctggtaacaa aggttactgt tttcggtata
    60961 ttgcaaccaa tttcgggatt ttcatgtaaa tatcttctcc atctaataat ttccccttct
    61021 attgactgcg cttctttaaa aaaatttttc atattccttc ctcctaatca gatagtcagc
    61081 aaaatctcac tttcttttag taatgaaatg atgctgatat aaaaattata attttatata
    61141 ttaaatttca tgtcttttta aggagttgga atatcatctg gaataggaca tttatatgtt
    61201 ttaccattca tagatttatc aaattcttct tttgcctttt tagctatctc tggattattt
    61261 aatattttag ctccaaacat agccataatc tttgatgcat atatcatacc tttttctcct
    61321 atagaacttc ctgcacaaga tgtaaactgc cagctatgac ctggtgctcc tagattcgta
    61381 caccctgtaa aaaagtatgc tgtcggaact atatgcatta catctccaat atcagtagaa
    61441 ccataactat taaagtttgt aacatttcct ccaccataat atagatgagt tccttctggc
    61501 aaattatatt tacttatcat agccttatat tgttgtgggc tttgtctatc taattcagct
    61561 gcaaaatcca attcctctcg agtccaaggc tcttgtttaa tctcattcat acattctgat
    61621 acaagatttg ctaaaacatg attgtttaaa gtattataac aacctcctaa aaactctact
    61681 tcaacttcag tttcagtcat cattgcagct ccttttgcta cctttacaag tctttcatat
    61741 gtactttcta cagcttctct acttaaagct cttgtataat accatactga tgctttatca
    61801 ggaactatgt tgggtgctac tcctccatct gtaattgtat aatgaatcct tacatcagaa
    61861 gtaacatgtt ctctcaaata attagctccc acattagtaa gttccacagc atctagtgca
    61921 cttcttccat tttgagggtc tgagcctgca tgcgcagtct ttcccttaaa gtgaaacttt
    61981 acagagttaa cagctgttga agtaccaatt gtagcttcac taattttatt tggatgaaaa
    62041 tttatagcta agtctaaccc ttcaaacgct ccacctctag ccataaatcc tttacctgtt
    62101 aattgttctt ctcctggaca tgcataaaat actatagtcc cacttaagtt attttctatc
    62161 atctctcttt taagccctac tactgcccct acatgtgctg tacataataa attatgccca
    62221 catccatgac catatgcacc caattcaaat gcttcttgct ttgttgaaac tttttgattt
    62281 aaaccaggta atgcatcaaa ttctcccata aaacctataa ctggtttacc tgaaccaaaa
    62341 ctagctctaa tagccgtggc taaacctcct acacctactt ccacatcaaa tccttcactt
    62401 cttagaaagt ttgctgtatt ttcacatgct ttaaattctt taaatgcttt ttctggattt
    62461 tcccatattt tcttacttaa atcatcaagt ttgaatcttt ttttatctat ctcatttata
    62521 gatatacttc ctatcatttc ctattcctcc tataagtata tttactatca accaaatata
    62581 attggaccta ttatactagc aaatgccact gatgcaatgg ttacagtaac aaatcctcct
    62641 ataatcatct ttggtaataa ataatctgtt gccctttgtt tttcttcttc agttccttcc
    62701 atagcatcaa taccttcgtt ggaaattatc tgtgttgcag gataagctag catacaagtt
    62761 acaccaattg cagctgacat tcttggagaa tatcccaata gttttcctac aattgcagta
    62821 aataatatta taaatacaga gcctacaaca agtattccta tagttggaac aatcatccca
    62881 aacaatgctg ttggagttac cttagcaagt cctccaggta acatcaacat acaaccaaac
    62941 attataattc cattagattg agatttatct aaaattcctt tttctaaaaa acctattcgt
    63001 gtaaaaatca accctactaa caaacatgct atattaggat ttaaataata gtttgcaggg
    63061 gtaaatcctg gtattaaagt agccaatcct acaaaattac caatcatagc aacaaatgaa
    63121 agctttgcaa gatacactag agtagatgat tttttaccta aatcttcttt aaaaattctc
    63181 atacttggaa gtttaaaatt actttttgac tcatctttca aaaaatcccc attatctctt
    63241 ttaaatttta attctttatt tatacaatat gtagttatcg gaatgccaaa gaacttttga
    63301 aatgataata ctagaattac aaatgcagca agttcaggtc tatttgcagc ttctgcaaca
    63361 gttgttacga taataccagc aacagtagaa cccgctattg gaggtgctgc tattaaagca
    63421 tactctctac caaataacat actacccact gttaaacagc caacccctat tcctacaata
    63481 cctactaatg caattacaac cgttttccat tcatgacata agtcttcaag atttataagt
    63541 gttcctaagt tagttattaa taaagctata ccaaagttgc tcattgcagc taatatccct
    63601 gatgctcctg taatgtcttt tggtaaaata tttgtccaaa atcctattaa aaatataata
    63661 catacaaata acaatgttga aattgcacct tttgttttct tagataaaaa ctcactaaaa
    63721 gcataaatca ttacacatac agtaaagcaa gtaagtggat tccaaaaatt ttccattgtt
    63781 gtttcctcct aaatataata attttttatc aataaaacaa taattataaa atgtatatta
    63841 tgcagttatt cttaactaca tatggtatag cttgatattt tttgatgata ttatatgcgt
    63901 cctaaattat tcctaaaata tctaaataaa tataactaga gttaactctc taaatattaa
    63961 ctatagttat caacttacta gatttctttt tgatttttac tttctacata attttacgag
    64021 ttagaattgt acttcaacta ctctctatat tagtatacat gttggaagac ttatatttat
    64081 ttaaatatta gatatagaat acatttttgc aaacgtctta aattattctt aaaatatcta
    64141 aaacgaaata ataatatacc cattaaacca atattatcag aatatacttc actttaagtc
    64201 ttctttatat agaaatttta tctattagtg catcccctcc tttgtaaatt agactatttc
    64261 taaacgaatt tagatatctt attcctagga actattacta gaaacaaaaa ttatttatta
    64321 tattaaatca atgataagcc atactttaaa attctttcta tacaagtatg atttatcata
    64381 taatgacatc tataccttta tctttatagt agtcctaaat tattcttaaa tttacaataa
    64441 aaataatttc actatttata aaaatacttg tttttatatt gtcaaactat tcttaatata
    64501 gattataatt ttaaatcttt tctttgtcaa tatattctga catttttcca gaaaatttat
    64561 aaagttatat agtgagtaaa tcatactatt tttatataat gagtaaatta tactatgaat
    64621 atgtctaaat atttacttaa gtataaacat aaaaaatgtg tattctcctt tttatagtaa
    64681 ttttagttgc cattactttt aagaagaata cacactttac tttaaagacc ctatactcta
    64741 ttttaaatgc tttactagac actaattaac attagttcct aacttctatt tatcttattc
    64801 ctaccctact actatatccg tagaaaaatc taaaacttct ccattagatt ttattacttc
    64861 tttgtaccaa tcaaatgatt ttttcttata tctcttaaaa cttcctttgc cttcatcatc
    64921 taagtcaaca tagataaatc catatctctt actcatctga cctgtagttg cactgactaa
    64981 atcaattggt ccccacatca aatatccaaa acattcaaca ttatcctctt caattgcaga
    65041 cttcatttga gatagatgct tacttaaata ttcaattcta taatcatcat ttatagttcc
    65101 atcttcttcg attttatcat atgcccctaa accattttct gtaattaaga taggtaattg
    65161 atactttctg taaatatagt tcaaggtaaa tcttaaacct atagggtcta ttgcccaccc
    65221 ccacttactt tgttccaaat atggattttg aatcccacca aataaagatt tatcacctga
    65281 taaattttct tttggagtag atacacttga aaaataataa ttaagtccta taaaatctaa
    65341 cttaccttct ttaaatgctt ttttgtcttc atcagtcact tcaatagtta tattattttt
    65401 ttcatattct tttaatttat attgtggaaa cttcccattg cacattgcat caatttgata
    65461 ataatcacgg tcattatcta aaaatgcatt taacacatta ctaggattac aattgtatgg
    65521 ataaattgga tttagtccaa atacacatcc aactttattg ttgggattga tttctctagc
    65581 caactttgca acctttacac ccgccaaagt catattatac cctacatttg ccaatgtttg
    65641 aaccttattt tctatttcac tatacttaat acctgctatc atataagtaa aaatatccga
    65701 gtgctctgtt tgagggtcaa tatggttcat ctcattaaat gtaacccagt actttacctt
    65761 atcatcaaat cttcttatta cagtctcact gtactttaaa tacaaatcta taagttttct
    65821 gttattccat gaaccatatt tatgtactaa attcataggt aattcaaaat gatatagtgt
    65881 tacaataggt tctatattat tttctattaa tgtatctatc agaccttcat agtatttaat
    65941 ccctaattca ttaggatttt catcatctcc atttggaaaa attcttgacc aatctataga
    66001 tattcttaat gcactaaatc ccatttcttt aaataaagct atatcttctt tatatctatt
    66061 ataaaaatct attccattat gagatggata atccaatttt tcttctattt tatcagtaat
    66121 tactcttggc gtttcataag agcccttagt tacaaaatcc ataattgcag gtcctttgtt
    66181 atcactatcc catgaacctt cacattgatg ggctgcaata cttcctcccc agaaaaatgt
    66241 atctttaata ttcatgaatt ttccctccta aaatttatac tattacagtt aataattctt
    66301 ctgattcatc atttgatgag attacatcta aataatcgct agtatttgta actacagtta
    66361 ttatagtaga atcaaagcct tcctctataa ttttatcaga ttcaaatact gctaaagcat
    66421 ctcctttttt aaccctttga ttttgtgtta caagactttc aaagaatttt ccatctaagt
    66481 ttacagtatc tatcccaata tgaattaata tttctaatcc ttcatcagtc actataccat
    66541 atgcatgttt agttggaaat actatagtta tagttccatc tacaggagat ataacagttg
    66601 attttgattc actaggtata actccaaccc ctttacctaa tgctccagat gaaaatgctt
    66661 tgtcattaac ttccccaagt gcaattacct gaccttttgc aacatttcca atactaatag
    66721 ttcttgaatt gttctcgttg attattagtt ctaattcttt ttcattatca cccttaactt
    66781 cttctttttc atctgaaggt attcctagta aataggaagc tgctgttgct gctacaaatg
    66841 atactactac acttattatc ataaatgtaa agttagatac ctctcctcca acaagatatg
    66901 ttggtaatgc agctaatccc caaaccattc catatgtttt aacttgagct aaacctgcta
    66961 ttaaaccacc tatacctcca cctatcatta ctgctacaaa tggtcttcta tatttcataa
    67021 acacaccaaa cactgaaggt tctgtaactc ccataagtgc actaaaactt actgtaccaa
    67081 ataattgttt ttgttcttta ttcctagttt ttaagaaata tccaaacatt gcaccacaaa
    67141 ctgcaatatc agatattgtt gcagcgccca taaaaattgg gtcatacccc aatgttgtca
    67201 cagaatttaa agatataggc atagtaaagt ttgctgcacc aaagactatt aagagtggtt
    67261 gtaaagctgc atacagtgca acaacactcc aattacccaa tgtatcaatt aaaaacatac
    67321 atgcatagtt taatccatca ccaatccaca taccaatagg tccaaataca gttaatgtaa
    67381 ttgatagagt tattattaaa gataatactg gaactaaaaa atagtgtaat gctttaggta
    67441 atattttttt caaaccttca attataattc ccattgccca tactcctaaa agtattggaa
    67501 taaaactgtt tgcataagtt gtagcctgta aatttatacc aaataaactt aatccttcta
    67561 caccatctat tgatgaagat aataacgtaa ctgctaacac tactgctata tagggattta
    67621 cattaagtct ttttgctgat gctattgcaa ttaatactgg taagaagtga aatgtagcac
    67681 ttcttaatgt atctaatatt tgatatgtag gactgtcact ctgaagtatg ccagacatat
    67741 ttaaaagtgc taacatactt gcaagtatac cagctgcaag tagtacttca attactgaag
    67801 tcatagtctc tgagactacc acaaagatgg aattaaatat acctttgata cctctaattc
    67861 ccttttttct ttcacttttt atacttgatt cacttgaact taaacctatc atagacataa
    67921 actcgttata tacatctaca acatgagtac ctattataat ttgataagca acatcattag
    67981 aaactacatc aattactcct tttaattttt taatttcttc tgtttgagcg atactcctat
    68041 catttaaagt aaatcttaaa cgagtaacac aatgcgctac cgactttata ttttcttttc
    68101 cccctataag ttttattata ttttcattta aatctttata tttcatctga ttttgcctcc
    68161 agtctttgag tcaccctatt tatatgcaac attaaataag tttcttcact tatagatata
    68221 tcgacattaa attgtgattt tatatatttt cttatctttt gaacacttcc aaatgacttt
    68281 ggataaagtt gacttacttg tttatataaa tctatagaat tatcttcatc tattgaagct
    68341 tcatccgaca taattctttg gataaagtac tgtagatgag tagtaaatct catataattt
    68401 gttgaagttt catctagctc tacattaaaa tgatatttta ttatagaaac tatatctgct
    68461 aaagttctca actctacaat tgtactatca tgagactctt tatttacctc catatttaca
    68521 aaatgaagtg ctattgatac tgcctcatca tcaggaagat taagtccctt actatcacca
    68581 attaatttta gtgcatgcat tccaatttca aaatgctttg gataaaatct tttaacattc
    68641 cataccaaag gactttttat aaattgattc ttttcacatc ttttaagtaa aaactctaaa
    68701 tggtctagta aggttaagct tagataatca cttgacttta tatttaaagc tttctcacca
    68761 tattcaatta tttcattaat aagaactata ttattggagt ctgagttttg tagtagataa
    68821 ctaaagtgtt ctagcatatc gtatgaatct agtatatatg ttctctctat ttcattttca
    68881 tttattactt gtcccactct ttttttaaag ccaattcctt taacaaatac aataatttca
    68941 tttttacctc tttttactaa ggctacatta ttatttaaaa tctgaattat tttcatatat
    69001 tcctcccttc aataaaaaga actcaagcat atatgtatag agtatccctc tatttttcac
    69061 atatatactt gagttctgcc tgctaatcag taacatactc aaaattatga ctacgtcgcc
    69121 ataattaaaa ttcttttttg tttaatttca tattctatat gttatactat ccatataaat
    69181 ctgtcaacgg tttcctagat atttttttat tctataacta caagctctgt tatgcgatta
    69241 tctgacaagg tttatatact aaattgatac tattttaccg tcactaatat ttataatatt
    69301 gtctgaacca ttatctattt tactattatg aattatcata gtaatgcttt taaatataat
    69361 gaactgtatg ttaacaaata aattcttaag atatattaac atataaagtc ttaagtttag
    69421 ttttatttaa tcactattaa gatatattaa taggtaaagc ttcaaattta gtttcattta
    69481 aatgctagta agatatacta atatataaat acttaaattt agttttattt aaacgctcta
    69541 gtgatatttt taaataaatt ttaataaaaa tcattctatt ttgtcataaa tcatttatct
    69601 ggcttatatt taagatatat tggtggatac tttacacttt ttaattcctc attacttctt
    69661 aaaagtttat tattattttc catatcataa atttgtaaca ttactttatt tacatataga
    69721 gcataataat tatcactata aaaatattga tactcatatc gagggtcatc tttgtaatac
    69781 actttgtata gtattccttc gtaacttgcc ttcttggctt tttcttttgt aatacttttt
    69841 atattatctt ttgaaatatc ttgttttacc atatacttat caatatatgt ttcagcatct
    69901 ttccatggtt taatgcagtt tttatataca acaaaccctg ttacacttat aatacctata
    69961 attaatacta taaaaataac tttatatttt ttcatattga tcctccttca tttattattt
    70021 aaaactcgat ataatgcact aaaaaaagga tgttatcttt tttattaaaa tataacatcc
    70081 ctcatattta gcatcaatat atatgcccca actggtaggt taaaagaccc cactgtcagt
    70141 actttgatta aattacatgt atgtatatat atttttaaca aatctattat atgtcaactt
    70201 gtctactatt acatataatc tgtaatatta catctgctgc tttttttgag cctcctgcat
    70261 tataaaagct ttttgatagt ttagttgcat tttctttata ttcattgtca tttataactt
    70321 gaaatactgc ttttttaata ctttctgact tatcctcttt taacataatt cctgctccca
    70381 aatgaacaac tctcttagct accattctct gctccgaatg ttgaggaaat aataccatag
    70441 gtactccata atataaactt tcattaacac tattcatccc agaatgagta acaaacacat
    70501 cagttttttg aagtatagca atctgttcaa cactattttt gacctcaaaa ttatttggta
    70561 tatttcctaa acttttaata tcagtacttc taccaacaga cataatcaca tcaacatcag
    70621 aatctttaaa tgcacttata cagtttttat aaaagctaac atttttatta ttaattgtac
    70681 caagcgaaat atatattagc tttctttttc tctctttagg ttcaataatc aactttgata
    70741 ctgatggacc tacaaatgaa tacttactag agaaggtttc taccattggt tgaaattctt
    70801 ttgatgtata tacaatggta tccgtatcat tatcattaga aactatagaa ataaaatttt
    70861 ttacttcata cccttttctt tgtaaaagct ttattttttt attaatgcgt cttacaccaa
    70921 aaatcatacg tataatttct ataaagtttt gtttcatcaa ctttgctgta tgtttattaa
    70981 atgcaaaagt tgttgtagag catacatatg gaatattaag tttttgtgca aataactttc
    71041 cccaaaaact taatgaatct gatacaatgc aatctggatt aaaatcttta agttctctac
    71101 aaactttttc atctaaagaa atagtagtat ctactatcat ctcaattaat ccaggaaaat
    71161 ccttaccaat ttttttctca tctccaggga gtaattctgg aaggtattta tcacaacaaa
    71221 taaattttgc tccagcacct tcaattttat ctttaaattc attaaaagaa taatacaata
    71281 cctcatttcc tctatccact aattcacgaa ctacttcaat agtaggatta gtatgaccat
    71341 atgcaggaat gctaaaaaat actattttac tcatatttca tacctccttt tataattttt
    71401 ttaaatcatt cttctttacg tactactccc acatgaccta taaaatttat caaatcacgt
    71461 tgatgaacaa ttcctaatcc tctttcctca tctccaagta ccaataattt atctcctgca
    71521 tttatattaa atacttctct tgcttctttt ggaatgacaa tctgaccacg ttcaccaact
    71581 acaactgctc caaagaaaaa ctttccttta ggaggtacta taatacctgt tttttcttct
    71641 gaatgattaa ctaagtcatc tagtttgaca ttgtacaatt ttgcaagttt aatgcaacta
    71701 catatatcag gaatagattc tccactttcc cattttgcta ttgattgtct agaaacatta
    71761 agtttttcag ctaattcttc ttgtgtatac tggttgattt ttcttagact ttttaaattc
    71821 tcattaatca tatttttcat acctcctatg tttataatat tggatttatt atttaaattc
    71881 tatcaactaa tcttaacatt catatatata tttatatact tttattatat aaatttatta
    71941 ttcaggtaac atatttcctt aagttatcgt aaacaaaaaa acaagcacaa atctactaac
    72001 tgttgttaaa gtatttaagt taaggtcatt tacattatca aatatttcta cacctttaaa
    72061 ataaccttta tatttataat ctttcataag caaattatta tcccttctca tatacaagtc
    72121 cagttgatgt cttgttgcta aatttaatgg taatcaaatt ctttaccaat aagtataaaa
    72181 attactaatg tgttataatt ttcttaacta ctaaatttta catacatttg aatagaatat
    72241 atcaataaat tactataata aataaaaaat agttagggag atattattat gattttatat
    72301 tttagcggaa ctggtaatag ccgatatgtg gctcgtaaaa ttgcacaaga attaaatgat
    72361 gaactgatat cactaaatca acttataaaa gaggaaaaaa cagatgaatt aatatcagca
    72421 gataaaccat tcatatttgt atgtcctact tatgcatgga gattgccaat agtagttacg
    72481 gattttataa aagaaacaaa atttctagga agcaacagag tttactttgt aatgacttgt
    72541 ggtggagata cagcaaaatc cataaactat attcaaaaac tatgtaaata caaggaatgg
    72601 caattaaaag gtatggcaga aattaaaatg ccagagaatt atatagcttt attttctaca
    72661 acagacaaag aaacatcaaa acaaatgatt aaagaagcag ataaacaaat atataggatt
    72721 atttctgata tacgcaatga aaatgaattt gaaactatta ctcctagtgg cttaggaggt
    72781 acaattaaaa gtggtataat aaatacagtt ttttataaga caattattag tgccaaagga
    72841 tttcattata ctgataaatg cattggctgt ggaaaatgtg tagagctatg tcctttaaat
    72901 aatattaatt taaaaaacaa aaaaccagtt tggaaaaata actgtactca ttgtatggca
    72961 tgtatttgtg gttgccccac tgaagctatt gagtataaaa ataaaactca aaacagagaa
    73021 agatactatt tagaataata tattcttaat atttaaacca ttataaaatg aactataccc
    73081 attgttttat acagttttac atattttaac cgtctcctaa aatgggtata gttcaaaaga
    73141 tagtgtctca aagtgaattt tttagttcct aaatcaatct ttttgtatta aatcaagtat
    73201 aatttaatca ccttttctta tatcattttc actaatatgt tgtattccaa caaatataag
    73261 atttattagc tctgttagtg acttccattg tgattttttt gaatcaagat aataataatt
    73321 tttcgttcct tctctacgca aattaacaat ctctgcttct tttaatatct taagatgatg
    73381 agatacagca ggacgagaaa gatgtgtttt ttttgtgatt tctcccactc gtataccatt
    73441 aaaatcactc tctaaaagag caattaaaat caattgtcta gtctcatcac ccatagcaga
    73501 gatagctttg cgacattctt taaatttaga cgttatttct tgcattcttt gttgacattc
    73561 tttttccata aaatccaccc tctcttataa gtatctaaca gttgctactt ctttctgtgc
    73621 agtacgtcta tatttaacat ctgggtatcc aattactaat gttgtaagaa catgattact
    73681 acgttttaga cctaaaagct tttttaattt tggcgaatta tttgctacat ctgaaaaata
    73741 tccactaaat aaaacaccta gaccataaga ctctgccatt aatgccatat ttgatgctgc
    73801 aagtgaacca ctaatcttat cttttgtaat tatcattatt gcaataggag catgcttaaa
    73861 gaaaaagtta tcgtcaatct caacttcttt tgaatattta atagctatat ttgcaatagg
    73921 ttttattttt ctaaaaaatt tcactgcttc gttttcataa attgactttt tattgtctaa
    73981 aacaatatat gatacatctt gtgaattttt agcactaggg gtatacctac ctgcctcaat
    74041 aatttgcttt ataatttctg aagaaacttc tttatcttta aatttacgta tacttcttct
    74101 agatttaatt gccattagta attcatctga atctagcttt ggcttatttg taagttctat
    74161 aggaggttca tcaaatcctg tcaaggtaat agcttttgtg ggacatattg ctgcacaatg
    74221 tccacacatt agacaatctt gttttttaat tactgacttt ttattttcta taattatatt
    74281 gtttactgga caatcatttt tacaaagccc acatccaatg caaagttctt tgtcaacttc
    74341 tattatatgt tggtatttca tattcattca tctacctttc gtttattagt ttaaactatt
    74401 ataacacgta gacatttttt atattcattg gtaaagaatt tgattaccat taaattttta
    74461 atttctctat taaataaatt tttcatagaa ttttaaaata tcatagttta tacataataa
    74521 aaaagacaag cttaaaacct aagcttgcct ttttcatctt ttattacaaa gtaaattgca
    74581 cttacttccc atacttctta acaattttat tttctaaaat tttatttgtg aatcatacta
    74641 ttgcatcaat acaatgtaaa ataattctat attgattttc tatagttaaa aaagttaaaa
    74701 attatactta ttattaattt ttatactctt cttatttaat acaaagttct tatttaacat
    74761 agatttcttg tctaatatag atttcttatt taacatagat ttcttgtcta atataaatct
    74821 tcaccatttg aagcaattac tttcttatac cattcaaaac ttttcttttt cattcttctt
    74881 agacttccat taccactatt gtctctatct acatatataa atccataacg cttttccatt
    74941 tcacctgtac cagcacttac taaatcaata ggtgcccatg tagtataacc taataaatcg
    75001 accccatcta tagaaactgc atcatgcata gcttttatat gttctcttag ataatcaatt
    75061 ctgtaatcat cttctacata accattttca tcagctatat ctttagcacc taatccattt
    75121 tctacaataa atagtggctt ttcatatcta tcatatacat gatttagtgt aattctcaaa
    75181 cctaatgggt caattggcca tccccattga ctgtatgaaa gatatggatt tttagcagat
    75241 gtaaatatgt ttccttcagc catatcatct gcattttcat cggttctaac acaacggcta
    75301 ttgtaatatg aaaatgaaat aaaatctact gtatatttat tcaataattc aatatcacca
    75361 ggttccattt ctggtgtaat acctttttgc tccatatact ttaacgcata gttaggatat
    75421 ttacctttag attgtacatc cacaaagaag taattttctc tatctaactt tgtagcttcc
    75481 catacatcat taggattaca actataagga tatacacttc cagctgcaaa catacatcca
    75541 attaagttat ttgaatcaac ttcatgtgct attttagttg caattgcact agctacaagc
    75601 tcatgatggg cagcttgata ttttatcttt tcaacatctt caccttcttc aaagcaaata
    75661 ccagcaccca taaatggagc atgtaaaatc atatttattt cattgaaagt tagccagtac
    75721 ttcactaatc ctttatatct tctaaagata acattgcata atttctcata gaaacctatc
    75781 atttttcgat tacgccatgc accatacttt ttaactaaat gcattggaca atcaaagtgt
    75841 gtaatagtga ctaaaggctc tattttatat tttttacact ccttaaatat attttcataa
    75901 aattgaagtc ccttttcatt tggtgtttct tcatcacctt ttggaaatat tcgactccat
    75961 gcaatgctca ttctatatac tttaaatccc atttcagcaa ataactttat atcttcttta
    76021 taattatgat acatatcaat accagtttta gctggataat aatgctcatc atcaaaatca
    76081 aacattttta gtttccctgt aataactgct gttctatctt ttcctgttgg acatacatct
    76141 acatttgcca atcctctttc gtcttcattg tatccacctt cacattgatt ggccgcagta
    76201 gctcctcccc ataaaaaatc attcttaaaa ctcatagtca aagcctccta aaattataac
    76261 caaagcacta gattatgcta atacctcaat ctttactaaa ataagactgt aattagattg
    76321 tcttctaatt caatattttt actttctgtt tctactacat ctaaaaattg tgatgaattt
    76381 gtaataacaa ttggagttac agtactatac cccaactctt ttattgcata aacatcaaag
    76441 tttaatatag tttgaccttt tgtaattcta tcaccttgtt ttatacatgc ctcaaaacct
    76501 cttccctcta attgaatagt atttaatcca atatgaataa gcacttcaac acctgtatca
    76561 gaaagaatcc ctatagcatg tagactagga aataaggttg taactacccc atctactgga
    76621 gcaactactt ttccatcact aggtattatt gccacccctt gacctagtac accagatgca
    76681 aatgctgcat cctctatatc acttaatttt aatacttcac cttttatagg acttgttact
    76741 atttctcttt ctaatttagt agacttgact tcttttattt cttctttacc cttatttctt
    76801 acttttttag actcttctac tttctcatct ttatataaaa tcatagttaa tacaaaagct
    76861 acgaccattg atatagctat accagaaaga gctactatta agttacccat tcccccatct
    76921 ggttcaatca ttgctggaag ttcaaatatt cccattcctc cagttataaa ttttctaaga
    76981 ttaaagaatc catagaaagc gcctccaata ccactagcaa tacaacttat tataaatggt
    77041 ttctttaaag gcaataatat tccataaatt gctggctctg taactccaaa tataccagat
    77101 ataaagtttg gtattgccat ctcttttagt tttttatctt tagtcttgaa aaatattgcc
    77161 aacacaactg ccgaacttgc aaatgtacag gcaaagaatg gcatcataac attatcatat
    77221 cctaaagtca taacattgtt tatatataca ggaataaatc cccagtgcat accaaaaata
    77281 acaagaattt gccaagtaaa tcctactata gcacctgcca atagtggact aaaatctctt
    77341 attgaaatta caatttgtga aataagtgta gaaccaaatg ttgctatagg gcctataact
    77401 ataagtgcaa caggcactgt tattaataat gtaagcattg gcacaaagaa aaacttaact
    77461 aaatttggaa cacacttatt aaataatttt tcacacctag aagcaaaata cactataaat
    77521 ataattggta cgactgttcc agtataatca attgatacaa ttggtagtcc aaagaaatca
    77581 atatatactg gtgatgcaaa cattgttcct ttaaataaag tgtacatcac atctgctcct
    77641 gctgatatac tgctaccttg tatagcagga taacatactg cagctcctag tgctaatccc
    77701 aacattggtt ttaatccaaa cttcttagct gaagtatatc ctaagaacaa aggaaggaat
    77761 gtaaataatg catctcctgc tgcatttatt accatataac caccagatac atcactatat
    77821 aatcccattg ctacaaataa tgcattaaat cctttcaaca taccacaagc tgccattatt
    77881 cctaacactg gctgaaaaat tcctgatatt atatctatac ctttatctag tatattacct
    77941 gattttttag tttctgaact tgtacttgaa tcatctaaac caattatttc aactacatct
    78001 ttatagacag cttcaacatg atttcctata actacttgat attgtcctcc acttttcatt
    78061 acagtaacaa taccttccat gttttttaat acattgtcat ttgctatact ttcatctttt
    78121 aaagtaaaac gtaatcttgt aatacagtgt actaacccac taatattttc ttttccacca
    78181 acattgttta ctatctcttg tgctaattgt ttgtattttc ccatttttct cctccatatt
    78241 tcgtttaaat taattttttg aaatttgaag gtttggccaa ctcaatgtta ccatccaacc
    78301 ataagtataa ttttgttagt atcactcctt tcaatcattc ttaatatact actgaaaaat
    78361 tatttcactt acatatttga gtctttaact actttagcta aatgtattgt taaatatata
    78421 agctcatcat ctgttaatat gtagttatat tgttttttaa tgaaattttt aattttaact
    78481 acacattcaa actctttatt atatttagat ttaataatgc ttagtaattc tttgtctgtc
    78541 tcaccttcat gtgcactatc taaaagcaat ctttgcgcaa aaaactttaa atgcattata
    78601 aatctataat aaaacactga ttcttcatga aattctatcc taaaatgata cctaactatg
    78661 ctaagtactt cttgtattaa cttcgtaata tcagatgcca aagtatgacc ttcacttaac
    78721 tgagcattca ctatatgaaa ggctataaat ccagcctcat cttctggtaa ttttatacct
    78781 gttttgtttt caataatatc tagtgctttc attccaattt caaactcttc tttataaaat
    78841 cttttaattt cccaaaggat tgcatttttt acatttattc cttctttcat cctttgaatt
    78901 gcagaatatg tatggtcact taaggatatg taaatacttt catttagctt cttgtttaac
    78961 tttatttgtg cgtattctat aatttcactt gataatttca tgtgttctat aggaatatta
    79021 ttgagtaatt cttgtagttt gtttgatatt tctttatttg atattctaaa tactttattt
    79081 actttagttt tatctattag attgcctttt gatttttgat aaccaattcc tttacccata
    79141 acgataactt cttcatcatt atcatctaat gtgattacaa cattattgtt taatatctta
    79201 ttaattatca tgattatcct ccttttaagc ataaaaaaag cttatccata ataatgggca
    79261 tactccttcc taggatactg ctattattaa tgaataagct tagcttgtac ttaaacaatt
    79321 actacctaat tccaattaat atgataaaac atcagacata ttttgtcaac tttttatttc
    79381 catatacttc atcaatcttt tatgttgctt tttgtcagtt ctaataatta ttcttattaa
    79441 tattaactta tttctttgca tcaatataaa tacaaaacaa gttatagtca ataataataa
    79501 aaattctatt aatgtaaata gttaatatta tacttcctct actacattat ctgtacttta
    79561 tttaacattt ttttcaactc caaaaacata tgtcataata aatggagcaa ccaatgctat
    79621 aaatataact ataagtccat ttactatatt tgaaatcccc ttttcccctg ataatccaag
    79681 tactgccatt atactatttt gtggaacata taaagtcaca tgagtaattc ctgcaaataa
    79741 ccctgcgatt cctgctccta tagatgctaa catagcaggt tttttaagtt tcaatgtaac
    79801 tccataaaga gctggttcag ttatacccat gatagctgat atccatgcag ctgatgctaa
    79861 ctgtttcatc ttactatctt tgcttcttaa tgctacagct aatgttgcgc caccttgcgc
    79921 taaattagca caaacttgag atattaatat tagcgattct tgtcctgtag ttgcaaatgc
    79981 tgatatgaat ataggagtca atgcatgatg catccctgtc ataacgataa atggcattgc
    80041 agctgctaat aaacaaacca ttataaatcc taaccttcct tgtagtaaat ttattatact
    80101 agctaatccc tctcctaaga aatttcctat tggtccaatt actattaatg ctattggcgc
    80161 acttattaat aatactaaag ttggatttaa aattgttttt aacatgctag gtgttaattt
    80221 atcaatgaat ttttctatat atgacatcat ccatactgtt aaaagtgcag ggataacaga
    80281 tgctacatat ataacacctt gaattggtac tcctataaat gatatagggt ccccacttga
    80341 tacccatgca gagaaatttg gatgtaaaaa cacacctact actataactg ctattgatgt
    80401 attaacatta aattttttag ctgcatttat tgcaagtatt ataggcataa agtaaaatgc
    80461 tacatctcct attatatcta atactctata tgtacttgaa tttgatgata gccaattaaa
    80521 agtggtgcaa agagataata taacttttat catcccagat gctgtaaggg ctggtatcat
    80581 aggtgtcata caaccagtta ttgtatctat tatattattt aaaatactat tttttttatt
    80641 ttttatatcg cttttaatat ctcctgtggt atttatcccc ttatttatta ttgcattaaa
    80701 tacaacacct acctcattac ctattataac ctgatattga gttgaagttg agtttactcc
    80761 aactacctta tctatagatt ttaatttatc tgcattgact ttcttttcat cttttaagat
    80821 gaaccttaat cgtgtcatac aatgagttaa gtcaattata ttatcctttc ctccaaggcc
    80881 atcaattatc aattgagcta cttcttcata tttattcttc ataccttatc ctctctttta
    80941 aaataatttt taatataatt ttaatccaaa ttaatctttt tactccaagc ttgtaatagt
    81001 gtattgcaat ttaataagct agtatcttct acaatatggt cacattttcc tagtacttct
    81061 tttttcccca caccaattga tgtcatatta gcagcattta tagctttaat acctgaataa
    81121 gaatcttcta ttcctacaca atcatattgt tttaaattta gaatcttgct cccttcaata
    81181 aaaatatcag gatatggttt tccccttttt aataaagatg gatttactat acaatcaaat
    81241 tcatctttta ttcccaaaga ttctaatatc ctaggtgcat tcttactagc agatgctatt
    81301 cccaatttca cattattttt tttaagttct tttataagct catttatccc tggtaatata
    81361 tctttatatg ttaatgagtt tattaacttt atataaatgt tatttttttc ttcacacacc
    81421 tttaactttt cctctttagt ataactatct actttattag cagataacaa tattttatct
    81481 aatgattctt ccctgcttat gccttttaat ttttcattaa aagtttcatc tatttctata
    81541 tctagcgatt ttgctatctc atgccaagct tcaaaatgat acttagcagt atctgttata
    81601 actccatcaa gatcaaataa gactgctttc atattaatta ctccctttaa aacaattatt
    81661 aacttctatt atgttctttg ataattttat ttctttatta tcatgtaata tggttatatt
    81721 tctacctttg attaacttat aataagattt atattcttct atatttacag aaactaaatt
    81781 atctctaaat aatatattaa atttaatatt tttccagtgt ttaggtatcc ttggttcaaa
    81841 acttaattta tcatttttta ttttcattcc tgcaaatcca tatactaaac tcatccatgt
    81901 tccacccata ttagcagcat gtattccatc acttgtattt ttttgtaggt tattaatatc
    81961 cattaatgct gtgtccataa aatagttata agctttttca tgatttccaa tttcacttgc
    82021 catcattcca aatattgacc ttgacaaaga tgaatcatga gtagttattt tttcatagta
    82081 ttcaaaatct ctcttctttt gttctaagct aaactcatca gggaaaagca acgctgaaag
    82141 tacagtatct gcttgtttat ttacttgata tctatatatt gttaatggat gataatggag
    82201 aagtaatgga tatttttctt ttggtgtatt tttaaaatcc catactgatt tttctaaaaa
    82261 tgaatcgtct tgtttgctta ttttcttctc ttcatcatat ggtaaataca tattttgagc
    82321 ggcatttatc cagtttttca cttcatattc ttgtaattta acttttctaa atacttcatt
    82381 tgaaaataaa ttatgcttaa atttatctac catctgtact gcatatatta aattatactt
    82441 agccattaaa ttagtgtagt aattattgtt tactattgct gtatattcat ctggtcctgt
    82501 tactccattt atacagaatt tattattttt tgattctata taatctccaa attcaaccca
    82561 aaatcttgct gtttctataa gaatttctaa gccattttgc atcataaatt cttcatcatt
    82621 agttgcttca aaatacgttc taataccata agctatatct gcatttatat gaaactgtgc
    82681 tgttcctgtt ggataatatg cactgcattc attaccattt atagttctcc atgaatataa
    82741 gcaaccttta tttattccaa gttctctagc tctttctctt gatgcatcta agattgagta
    82801 tctataatct aataaagctc tagcaatgga tggttgagta tatataaaaa atggtaatat
    82861 atacatttct gtatcccaga aataatgccc ctcatagcca tcacctgtaa gaccttttgc
    82921 tgatatatta gtctttccat ctcttcctgc tgattgataa atatgaaata aattggtttt
    82981 tatccccagt tgaagagttt tatcgccttc aatctctaca tcagaggttg tccaaaactc
    83041 attcattttc tttctctgaa tatttttgac tttatcaaat ccaatattac atgcttctct
    83101 taaaaccaat tctaatgatt ttaaatgtgc ttctgattct aaacatttta acgactccag
    83161 acattctaat gattttaaac gttcttcatt tagatttaaa tcagaatata ctctactata
    83221 gcctacaaca atttctaaat ttaacctttc atcttttttg gcatagactt ctatttctcg
    83281 ctcaatacat tcatctgaaa cattataggt ctcatttgta atatttccac aagtaatata
    83341 tgaatcaaac ccacaccata accctaatct acttctttct gtaactaaat tcataaaata
    83401 cttattgtta tattttttta cattaatttt aaattgcttc ttatttatag atgccactct
    83461 tgggtcatct actttttcac aattaaactt ctccatacta ttttccattt tatttttaaa
    83521 ttttattttt ccattaaaat tcaatggtgt tattgtatat gaaatcatca ttaattcttc
    83581 tatatcttgt gatactaatc tttctataga tactttaact tttctaccac aagagttttc
    83641 ccatataaat gaacgtttaa gaatcccttc atttaaatct agtatcctag aatgttcact
    83701 tgtaatacct tttgataaat caaaataatc tccttcaata gagaaattta ctatatgagc
    83761 attaggtaac ttacagatag tctgattttg ttttgcatag ccataagcgc tttctccata
    83821 tgtaattgga gattcttcat aaaatccatt tacatatgta cccatattat ctacatactc
    83881 attattaaaa tcagactctt caatattccc tctaactcct aaatgtccat tagctagtgt
    83941 aaacagcgtt tcattggatt ttattgtatc cttactaaac ccttgctcta taagttggtc
    84001 cttagtagta aatattaaac tcataataac actcctttct taaaatgaat tatgcatgag
    84061 tttccatgtc attaaataaa atttctccat ctgtttctat tactttttta taccaaaaag
    84121 cactttgttt tttagttctt ttaaatgagc ctcttccata gtcatcagaa tcaacatgaa
    84181 ttatgccata tcgttttgtc atctttcctt cacttacact ggttacatct atacatcccc
    84241 acataagata tcctataagc tctattccat cttcatttac tccaagaatc atatttttaa
    84301 tatgttcttt catgtaatct atacgataat catcaattat ttttccatct tcattcacaa
    84361 tatcttgagt acccagtcca ttttctacta taaataaagg taactgatac ctttcatata
    84421 actgattcat agttattctt aaccctacag ggtcgttttg ccatacacta tttgattttg
    84481 gaagatatgg attttttatg gtttctggtc cgtttgcctt tgatttttct aaaccttcag
    84541 ctctagctga actacaagca ctagaataat agctaaaaga tacaaaatct acagtattat
    84601 ccttaagtgt tgataaatct tcctctttta ttattaattt tatttgattt gattttaaat
    84661 aataattcat aaagcttgga tacacacccc taacttgaac atcagaaaaa aacaaattat
    84721 acctttcatg ctctaaagtt gcaaatacat cttctggttt acatgtgtat ggatatgttt
    84781 ttccagcagc taacatacac ccaaacttaa attctttatt tatatacctt cctatttcta
    84841 tagtttttgc attagctaat aattgatggt gtgctgcttg atattttttc tgaagttgat
    84901 tttcatcagc tataaaagtt aacccagcac ctatatatgg aatatgcatt atcatattca
    84961 tttcgttaaa aggaatccag tatttgacat catctttata tcttttcatc aaaatttcag
    85021 catattttac atataaatta accactcttc tatcagccca cccagaatat ttttcaacta
    85081 gagaataagg tatatcaaag tggcttatcg ttattaatgg ctctatatta tattttttta
    85141 attcttttat tatattatca taaagttgta atcccttttc atttggttca ctttcttctc
    85201 ctgttgggaa tattcttgac caagatatag aaaatctaaa acatttaaaa cctatttctg
    85261 ctaacattgc tatatcttct ttgtaatttt cacaaaattt aatccctata tgacttggat
    85321 agtattgatt attttcattt aaaatattat cctcatctaa acatacatct tttaatctct
    85381 tatcatttaa tgggagttta tcaaactgag ataaaccttt tcctccatct aaataaaatc
    85441 cttcactttg attggctgaa attgcccctc cccataaaaa atctttccct aatttcatgc
    85501 atctacctct ttcacaatat aaagttttat aatttctatc tcatatttag ttataagatt
    85561 tttttcatac tatacctttt aaataattca atttaaaaat ccaattatat tttttactca
    85621 ctataattaa tattgtctat tttcaatact ttcatattaa atatcaatat tagatatcta
    85681 tgtatataat tatatatata gcaaatacat ttttatatcc tcattattgt tatcttattc
    85741 tcatatattg ctgtatattt atatataaaa ggatttattt cgaaatagag gttgtattga
    85801 gaactaaaat ttagacttta taaatgaatg gaattttcat tgttgaaata ctgaaaatat
    85861 atttgatttc atataaaaga aagtgcctca tgaactaagt tcattttgag acactccctt
    85921 ttttttccaa gctattatat ctttttttaa attctaatgg agagactcca attttttctt
    85981 taaatactct gtaaaaagtt tttgtacttc caaaaccaac ttcttcaacc aaatctacaa
    86041 tggatatatt gttattaagt aatatccact ttgctttttc taatctatat tcatttaaaa
    86101 aagttataaa tgtttttcct gtattttttt tgaaaaattt agtaaaataa tatacactaa
    86161 atcctacttc ataagacaca tcttctaatt ttataggttg tttataattt ttttctacat
    86221 atttgaatat attgttcaat ctctctaata tctctttaga gtttatttca tattctactg
    86281 tattttcttc aatttctcta ggaatctgtc tatataatat aggaattaaa ttatacattt
    86341 taccttttat tgcataacta tatccttcta ttttgtatag gtcttcattg tagatatcta
    86401 tcaatatatc gaaaactgac tttcttattt ttgctgacca atctctacta cattttttta
    86461 tactactgaa taaattaatt aagctttctt tttcctcatt taataaaatt aaatcattaa
    86521 aaaaagatat atcaaattga aatactaatc tttcacttcc cggtgatggc agtatataat
    86581 gaatatctcc tccttttatt atcactatct cgcctttttt taattgcata ggcttgtcat
    86641 ttataaatag atttactaca ccttctgtta taagtaatat ttctatttcc ttatgccagt
    86701 gtggtgttgt taatacttct ccttcatttg atagactacg aaaaggaaat tcatgtatta
    86761 atttaggcat ttctaaatat attgccatat atatcctctc ctctctagtg tctaaaaatt
    86821 aatttatact atttaaaaga atacacattt tattttaaaa acctcaaatt tataatttat
    86881 acaataccta cacttcataa aatatatcta atatttcttt ttttgtattt gcatttaaaa
    86941 gtctttcacc tatattttta ccacctaaaa tgtaagctat tttagatatt aatatcatat
    87001 cttcattgcc tccagattgt ggcatagcaa acataattat tacctttaca ggtaagccat
    87061 ctatacttgg ccaatctaca ccttttttag atttacctat tactatggat gccttcttta
    87121 catattttgt ttttccatgt ggcatggcca tttgataacc tatgctagta gagcctattt
    87181 tttctctatg ttttaatgcc tttataaact tactttttaa agttatactt cctgtatcgt
    87241 ataatttatc tactaattcc tgtattatgc cttcttttgt agttgatttc aaatctaaaa
    87301 taatgctttc ttctgttaat atttctctaa tttccatttg ttttctccaa tagattattc
    87361 ttaaataata ttttaatatc ctctttgctc ttgcaatcta ttatatagtt tatatagttc
    87421 ttttgcctat ataaatttga tatttccatt aaaatattct ttaaaaaact ttgattacta
    87481 atttctaaat aaatatcaat cgttctagta acattattga tattcattat ccctttattt
    87541 aatttacttt gcttatgtat atatatattt aaatcttttc ctaatgaaat agattcatat
    87601 ttactcccta aattcacacc tattaaactt tccatctgag ctacatcaaa attaaaatat
    87661 atattatctt ctaaatacat tcctaataag tttgtatcta agttcatact ttttttaggt
    87721 ttagaaagta aagcattttt tatattatta atatcatttt ccattaatag tactgataca
    87781 actatatgta atttatcttt caaatctaag tttacagtag atattacaaa gtctacatca
    87841 tctaaatttc gcttactcaa ctgatgcata ggaactatat caactatagt ccattcagga
    87901 aattctcttt ttaatctggc tgcaaggagc tgagatgttc catatcctgt atgacaaact
    87961 actattactc ttttactact catatttctt tctattgccg cttgaaaata tgtggcaaga
    88021 tacgaaactt catctatact aatattcttc agattatcat actctgtcat aatatttata
    88081 gtcatcatac ataatcccag cacatctgaa aatcgctctt gtatctctcc taacaacggg
    88141 ttttttattt ggatatcata tcttaatctg tttaacatag gccttacatg agatgctaga
    88201 cttttctgta gtaagtcatc atttttgaga tttatattta aaaatcgtga catattctct
    88261 atcattatag atgaaacttt ttcactttca cttaatctat ctgattcatc attgtaacta
    88321 ctattatttt cgctactaaa tccagatgat accaaaaaaa tatatatgta cataatttca
    88381 tctttcgtta tttttactct gtatctattt tctattttat ctataagtgt actgacattt
    88441 ttatatacta actcgtccaa attatctaca gaaatttctc tttcttcctg agattctatt
    88501 tgattacctt cttcgattct ctttaaacat ataagtatat gggtaattaa atttatatag
    88561 tagggctgat ttatagtata tcctaaattg tattctaatt ctgtaattat agtttctaca
    88621 aatataatag aatcaatatc aaataaattt atcaatgcac taaatgtagc agaatctaat
    88681 cttgttaact cagatatatc atgttgttca taattttcat ctaataaatc atccatcatt
    88741 ttggcaatcg atttccttat atccacttct ttacctataa tcttagttcc ttctaaagtt
    88801 ttattaagtt ttaaattgta ttcttttatc catgcctcta tatatttaaa atcatttact
    88861 atagaagttt tacttacata atatttatct gctaactgat ttattgaagt tatattattt
    88921 gaatttagta ataaatactt taaaatctcc attcttctct gctctactga taaagattta
    88981 ttttccttcg attgtatatt taaactatta attaagtcta tattcttctt tgctaaatct
    89041 tctattaata ttccatagcc tctttttata tcaattttta tattaaaagt ttctaaatat
    89101 ttctcaatca tcttcaaatc tttttgtaaa gttttatcag atacatttaa tttatcttta
    89161 aagtatttta taggtctata tttattttcg tttagtatca atttaagaaa ttcaatttgc
    89221 ctcgacacaa gcatacttag ccctccctac ctatgtttat atatttctat gtttatatta
    89281 agtactattt taacatattt actaactatg taaaattact aagatacttc tgtatcataa
    89341 aagaatttat gatacacctt actaaattga tataatagat aatataattt caaaataaaa
    89401 attaaggata tttagaagta gttaactgat tctaaatatc cttattatta ttctatatac
    89461 ttgttgttat tccattaatt atttttacta ttatttataa tttaagcacc aagtaattca
    89521 acttcactat tttcactcct tatagtaggc tttgttaccc ctataatcaa tgctgttatt
    89581 actgtaccaa tcaatataca agctatatat gcaactggtg cactacatgc aaatggtatt
    89641 acaaatattc ccccatgtgg tgccattaaa gttatatcta aactcataca tattgcccca
    89701 cctatacaag aaccaattat atttgctgga atcattctta atgggtctgc agctgcaaac
    89761 ggtattgcgc cttctgttat gaaagatgcc cccattatag cagttggtag agatgacttt
    89821 ctttcttctt tagtaaactt atttttgaat attaacatag ctaatgatat tgctaatgga
    89881 ggtaccattc ctcctaccat taatgctgct gatggttcaa atatattact tgaaaacata
    89941 gccaatccaa aagctgaagc tgttttatta ataggtcctc ccatatctga tgccatcatc
    90001 cctgctaata ttgcacctaa taatacttta ttagttccag acatactttg taaccaagat
    90061 tgtaaagctt catttaacca tgatgctggc gtattaacta caaagaacat tatagctcca
    90121 ctcgtaaatg caatcaaaag tggacatatc aatacagcat ttactccttt taatacatct
    90181 ggtaaatttt ctgttatctt cattactcct aaagctatat atcctgttgc aaaaccagct
    90241 accataccac ctataaaacc tgaacctcca ataactgcca taaaaccagc tatcatagca
    90301 ggagcaaatc cttgtcttcc tgctattgat ttagctataa aaccagcaag tatcggtata
    90361 aataacttaa atgctgaatc gcctccaagt tgtccaaaga atccagctat agggttgtat
    90421 gtttcatgag ttgggtctga tgcaaatata ccaaacataa aagctatggc tataccaatt
    90481 ccacctatca ctacaaatgg aatcatttca gatacaccac tcattaagtg cttataaaca
    90541 ccctttttct ctgacccttg aagcatttct tttgaatctt ctaaagtctt tccacctggt
    90601 ttaatttctt tagccattcc attttcagcg tttataatta aatttttagc taatgaaaca
    90661 ttcttagcat ctactacttt cttttgtagc actttctttc ctataaatct actcagttga
    90721 acttctttat cacaagctat tattacgtat tcagctcttt ttatatcttc tttagtcaac
    90781 ttattttcta cacctatagc tccatgagtt tctattttaa cttcatatcc aagttcttga
    90841 cctgcttcct ctaatgcttt ttttgccata aaagtatgag ctatacctgt tggacatcct
    90901 gttatcccaa ctataagacc tttattttga ttattactaa aatctcctga ttctgcagct
    90961 ttattattaa atatacttaa tatttcgtat ggagtttctg cacttagtag atgcttaaga
    91021 aaattttctt ccattagata tgtagctagt ttagatataa tcttaagatg ttcatctgaa
    91081 cctgattctg gaactgctat cataaaaaat gacctaagtt tttgaccatc attatctgta
    91141 atctctctat ctgttcttaa atacatcatt acaggttgat ttactacatt tgacttagca
    91201 tgaggtatag ctattaaatt acccatatta gttgatgatt ctttttcgcg tttattaata
    91261 tcagctataa acttttcttt attatttata taatttccat ggtacaaatg atttgccata
    91321 taattaatta catctttttt tgtttgtaat tgtttatcta gtacaataca atcgcttcgt
    91381 agtattttac ctatcataaa ttctcccctc cttttaattt gttacctcat aattaatttt
    91441 tatttttata aaagcacttt aacttatcta tagcattgaa tagattcatt ttaaactcta
    91501 taacttctct tgcagatttt atacatggtg gatatatagt atctggctca tataagcttg
    91561 ggttttgttc taatagttct ctgcacttct tataatatgc cgacttaaca tcactcgaaa
    91621 tatttatttt acaaactcct agtttaactg cttgtgctat ttcttcatct ggatttgatg
    91681 aaccaccatg aagaactaaa ggtatatcta ctacttctct tatttctttt aataaatcta
    91741 gtttaagctc tggtttaaaa ccttttggat atataccatg tgctgtacca attgcaatag
    91801 ctagtgtttc tactcctgtt ttttcaacaa aatccttagc taattttgaa tctgtatata
    91861 ttatttcatc agtaccacct tcacttgatg ttcctgttgt tcctattgtt ccaagttctc
    91921 cttctacgga cacatttaat ccttttgcta tttctactat ttccctagat atagctacat
    91981 tctcttcata tggtaaatgt gagccatcaa tcattactga tgtaaatcca catcttattg
    92041 cccttaatat ttgttcttta ttttccccat gatctaagtg tattaccata ggtactttac
    92101 tcttatttgc ttcttctatg caactagcta caaagctatc tcctagaaaa cttagctcat
    92161 ttgggtgtat tgcaagtatt actggtgcat ttttttcgtt agcactctgt actactgctt
    92221 taagtatttg cccacttcct atattaaatg ctggtacagc aaattgattt tcttgtgcca
    92281 cttttagcat ttccttcatg tttattaaca tattgtacct cccgatattt taaattttag
    92341 gttgaatttg cttcttgtta attttgttgt tgtttatatt taaataatat cagggtaatg
    92401 aatgtcagaa aataacaatc gttttcctta gtgaaaagga acttttatta tacactctaa
    92461 gttccttttc actaaataat ttttagaagt ctgcatcata gttaattata tttctcatgt
    92521 acatcttctc tttttaagtg ttttatgctt tagccttcct agattttata ataaacaatt
    92581 aagatacatt aactataaat ttaaagatac tcatgcaata gttaatgcta tattagagtc
    92641 aaaaaaatta aaaagatatt agctatttgg ccaatacctt ttcttggatt ccaatagtat
    92701 atacgattta tagaaatctt actcacgatt atctaatgtt ttacttccat aaactttaca
    92761 taaaacacca aagtgacacc ctccaaattc atctctagct aataaagtga tttggttttc
    92821 taagcaccaa tttataaatt agcctttgtt atcttatgta aatctttttc tatctaattt
    92881 aaaaattatt cctaatgcta tatagcatat accaattact aatacaccat aagccataga
    92941 tactcctatc ttaaattctt gcatattaat tacaatagaa actgaaatag atttattaca
    93001 aacaccataa agcaaggctg acattgtata ttatccaatt gtatgaatga atactaatat
    93061 agctcctttt aattaaatga tgctatataa atcatattta tcccaatttt taatctaacc
    93121 tatttatatg tatattcctt tttaataaaa aaagatattg actaaatagt caatatcttt
    93181 tagttgattt aaatacccac aattttaatc taatttttaa gtgtttcctt aacataatct
    93241 tataaatatt aaaatttatc tacctataaa atttctccat taaatttt
//
LOCUS       DAEQCW010000003        88877 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.003, whole genome shotgun sequence.
ACCESSION   DAEQCW010000003 DAEQCW010000000
VERSION     DAEQCW010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 88877)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 88877)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..88877
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.003"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            114..443
                     /locus_tag="KRO40_000166"
     CDS             114..443
                     /locus_tag="KRO40_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091011.1"
                     /translation="MQLNKEVLKGYIDILIVSILEKKDCYGYEIAKQVRERSEFELKE
                     GTMYLALKRMESKNLIKSYYSNEQSSGGRRKYYNLTNEGKDFLEIKKQEWRFIKKVMN
                     QFLGEVD"
     gene            447..1238
                     /locus_tag="KRO40_000167"
     CDS             447..1238
                     /locus_tag="KRO40_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091012.1"
                     /translation="MKLIDEYLDKLYKKCDNKSTIELKQEMRCHLIESANEFKLEGLD
                     EEEACKKAIERFDDGDEMQYELCNIIKELSLSLDRHKSIVMGFKKVLGYISIIAFLIS
                     GFMWYYNNSLQHNMYNLGKELDGEIKQLAERHDMTKIGEYKLELEKILDKDKYSKVKA
                     LRLYVIDMKDGNTNLSSSGLNANMVYEREADYNNISNFIQHLGYNGKDFLDKNGNIVN
                     PDIFLEYFFYFESEMLIPVAFAFGLLCIIAYFILRFKISLIKNNN"
     gene            1802..2884
                     /locus_tag="KRO40_000168"
     CDS             1802..2884
                     /locus_tag="KRO40_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH2091013.1"
                     /translation="MKKIRKLATKLLIAMMVLTSCMSVTVYGMTAKDVTAKTPKSYVA
                     GTNSIYGPKLSQAQLNSVAQATADFMNKKITKNMTTDAKIRVAYNHIKNNTTYVNWNA
                     AEGANTAYTLVTKKGACSGMCRSLKALCDAMGIECYYVHSTTNDHQWNLIRFEDGRLY
                     HVDIDANKSAGADIIYKSLTHPLPFDKKAYPAVGEVVKTQNPTPTVKKPTPAKPSAPV
                     GPGNHTMIADQQGAILDEVYGNNLRPKIEMYEGVPCSLINSSINTIKFTSKNSNLDPS
                     KHTVTVIGFMNTPYGMVALAPDGVPDEYPFEYDKPFSLDFTGKNLSAAELSKKCKENN
                     VIIKVEIGETASNSGRGMVAYARYVN"
     gene            complement(3096..4289)
                     /locus_tag="KRO40_000169"
     CDS             complement(3096..4289)
                     /locus_tag="KRO40_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FprA family A-type flavoprotein"
                     /protein_id="HBH2091014.1"
                     /translation="MSKVFEVKKDIYFTGVVDEGLKVFDIIMETEFGTTYNSYLIKDE
                     KTVLFDTVKANFKDEFLSNLSEVTDIAKIDYVVIHHTEPDHAGSLKYLLDINPNIEVY
                     CTKAAKLYLDGQINRPFNCHVIKDGEILNIGKRNLRFITAPFLHWVDTMFTYIEEDKT
                     LLTCDAFGCHFASVDAEVVNSEDYLKSAKHYYDCIVKPFAKHVLSAVDKVVGLNIEFD
                     TILTSHGPMLTKDPMAAVKRYVEWSTEAVNTTNQNQVSIFYLSAYSNTLEMAKKIKEG
                     LDKEGAKAELYDLEDMTLTEMHDTLVVSKVILLGSPTINKTMVKPMWDLFSVIDPMAN
                     QGKIAGVFGSFGWSGEGITMAETLLKSMSFKMPVESLKKKFFPSEETLKECMAFGAEF
                     AKLVK"
     gene            4608..6452
                     /locus_tag="KRO40_000170"
     CDS             4608..6452
                     /locus_tag="KRO40_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03960 family B12-binding radical SAM
                     protein"
                     /protein_id="HBH2091015.1"
                     /translation="MNKVDLKKILKKVEKPARYLGNEINSIHKDTSNSELIRYAHCFP
                     DLYEVGMSHLGSHILYDVINKDEDVFCERVYSPAVDMENIMREKSIPLFALESREPIT
                     NFDFVTFTLQYELSYTNILNILDLANIPILKEERTLEDPFIMVGGPCAYNSEPLADFV
                     DVVILGEGEEVNLEVVNEYKEWKKNKTTREDFLYKISSIEGVYIPSFYDVKYNEDGTV
                     QSVTPNREGITKNPTKRIIKDVETVDYPEKLIVPYIDTVHDRIVLELFRGCTRGCRFC
                     QAGMIYRPIREKSVKRLKEILDKLVKNTGYDEISLSSLSTSDYSKLSELTDYLVDEYA
                     SNNIGISLPSLRLDNFSMEIADKIQQVRKSGLTFAPEAGTQRLRDVINKGVTEEDLEN
                     ATERAFEMGWNSVKLYFMIGLPTETYEDLDGIAKLAYKVIDIYRKVNGGKLKRSFSVT
                     VSTSTFVPKPFTPFQWHGQDTTEEVINKQRHLVNKLRNNNIKYNYHDSKTSLMEAVVA
                     RGDRRIGKVIYDAFRLGAKFDGWAEHFNLDIWKEAMEKNNLSIDFYAHRNRNYEEVFP
                     WDHIDVGISKKFLIREDENAKKEKITSDCRHNCNGCGINIHDIGRGLC"
     gene            6454..7155
                     /locus_tag="KRO40_000171"
     CDS             6454..7155
                     /locus_tag="KRO40_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2344 domain-containing protein"
                     /protein_id="HBH2091016.1"
                     /translation="MSKIIRVKFKKEGDMIYISHLDLQRLLQRAFRRAEINLSHSQGF
                     NPHPKMSYGNALALGTESQGEYVDIEIEEDDLSVEEFLNKVSIQLPDGIDFIKAKEID
                     RQTPSLSSVIDYGEYLFNIDLKRPMTKEFVKRKVIDFMNNKEIIITKKNKKGKMVEVD
                     IRPMIRTFDVLNLEDEHITLTATIATGSKTNLNTNILIPKILEMFELDIDPLDVDILR
                     RDLYVLEDGELVTPM"
     gene            7173..8594
                     /locus_tag="KRO40_000172"
     CDS             7173..8594
                     /locus_tag="KRO40_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rne/Rng family ribonuclease"
                     /protein_id="HBH2091017.1"
                     /translation="MKKIVIESLIGSQKTAVLEDERLTELFVEDNLNKKTVSNIYRGI
                     VKKVIPGIEACFVDIGFKKLAYLQLKKGSTIKSGQDILVQINKEEIGTKGAKLNTEIS
                     ISGRYIVYIPSNDRTTISNKITDEKERFRLKKITKAVNKENLGLIIRTEAQGCTHDEI
                     KKDIEELKLKYENILKEYKLGIGPKLLYKSLDFATKYVKDNVNDDIESIITNSYDKYS
                     ELKSILRGIDKTYVDKLCLEENRDVFDLYRIESKIEKLLNKKVWLKSGGYLIIEKTEA
                     LTVIDVNTGKFIGTGKLDETVYKTNLEAAKEIVRQLRIRDIAGIIIIDFIDMHKKKHQ
                     KEILHILEEEFNKDKRKAEVLGMTKLGLVEVARRREKESIDKYYLMSCPCCDGEQTIK
                     SVHYILDSIEKEIMRISEHTVYKNIMVEFNDFIFEQIKEYYMDIIDKIGEKYNIKISL
                     NANSTLKHNKTNVIFDKIVDNKM"
     gene            8695..9006
                     /gene="rplU"
                     /locus_tag="KRO40_000173"
     CDS             8695..9006
                     /gene="rplU"
                     /locus_tag="KRO40_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HBH2091018.1"
                     /translation="MYAIVKTGGKQYKVSEGDVLFVEKLEANAGDVVTLNEVLACSKD
                     GELKLGSPVVEGASVQAKVVEQGKAKKVIVFKYKAKKDYRRKQGHRQSYTKIVVEKIN
                     A"
     gene            9021..9338
                     /locus_tag="KRO40_000174"
     CDS             9021..9338
                     /locus_tag="KRO40_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HBH2091019.1"
                     /translation="MIKVKYYYNDDFLLQGFCLKGHADFAEIGYDIVCAAVTSNAIAV
                     INSLDKLQKIEFEKVVGEEGHIECIVKDTHVKDAQLLLNHFQLAVKEIKREYPKNIKI
                     LKK"
     gene            9352..9642
                     /gene="rpmA"
                     /locus_tag="KRO40_000175"
     CDS             9352..9642
                     /gene="rpmA"
                     /locus_tag="KRO40_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HBH2091020.1"
                     /translation="MLNMNLQLLASKKGVGSSKNGRDSISKRLGVKRFDGQLVTAGSI
                     IVRQRGTKIHPGTNVGKGSDDTLFALVDGTVKFERKDKKRKKVSIYPVAIAE"
     gene            9753..11030
                     /gene="obgE"
                     /locus_tag="KRO40_000176"
     CDS             9753..11030
                     /gene="obgE"
                     /locus_tag="KRO40_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HBH2091021.1"
                     /translation="MFIDKARIFVKAGNGGNGSVAFRREKYVPAGGPDGGDGGRGASI
                     IFEVDLGLRTLMDFKYQKKYQAQNGGDGSKGKRAGKNGENLVLKVPAGTVIRDEATGL
                     VLADLKKEGDTAIVAKGGIGGKGNQHFANAVRQAPAFAKSGTDGEERWITLELKMIAD
                     VGLLGFPNVGKSTFLSVVTKAKPKIANYHFTTLTPNLGVVQTKFGDSFVLADIPGIIE
                     GASEGIGLGHEFLRHVERTKVLIHIVDISGLEGRDPIEDFDKINDELKLYNEKLSKRP
                     QVVVANKFDILEDESKFEKFKSELEGRGYTVFKMSAATRQGIDEVIAYVSKMLKEVED
                     VELVSEEEMYRPELDIGTEEELSIDIEDGVYVVTGKALRRIMYSVNFDDMESLQYFQK
                     AMESQGVFDRLREMGIEDGDVVKIYELEFEFYN"
     gene            11082..11450
                     /locus_tag="KRO40_000177"
     CDS             11082..11450
                     /locus_tag="KRO40_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhbY family RNA-binding protein"
                     /protein_id="HBH2091022.1"
                     /translation="MLKGKQRAYLRSLANTLKPTTQIGKEGVTESFLEQLDGMLRTRE
                     LVKVTILENAGLDTKETANAVCEALRAEFVQAIGFKFTIYKRNIEEPKILFPGHEQAK
                     AKTKNNNVTKKGKPTKRAVR"
     regulatory      11542..11648
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            11751..12956
                     /locus_tag="KRO40_000178"
     CDS             11751..12956
                     /locus_tag="KRO40_000178"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBH2091023.1"
                     /translation="MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYK
                     KYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVTRALNKKIHVVTANKDLLAEKGS
                     DLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
                     ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGIT
                     SIDEKDIEYAKKLNCKIKLVARSKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILV
                     GDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKGKLDLSGLIEDECSA
                     VVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSE
                     SAKKLLKID"
     gene            complement(13157..13723)
                     /locus_tag="KRO40_000179"
     CDS             complement(13157..13723)
                     /locus_tag="KRO40_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH2091024.1"
                     /translation="MATRPIEIDEYKKIMELLHTGFTYSENGVEKRFRKNPKVALALM
                     LEANLGLRISDILRLKIGNFKGNMLEINEKKTGKLQYRPVNKNIIESINEHARKYNLK
                     SNDYLVNIKTKAIQKQLRIICKYLNLYNISTHSFRKLYATTQFEKSNNNLELVKELLN
                     HSSVATTQRYIRVTQQAINEASENFFIG"
     gene            complement(14003..15262)
                     /locus_tag="KRO40_000180"
     CDS             complement(14003..15262)
                     /locus_tag="KRO40_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YlbJ"
                     /protein_id="HBH2091025.1"
                     /translation="MKKNKIIAFFAPSIIVGVLVLGIILYPNEAIKSAREGFSIWSNV
                     LVPSLLPFIIGANLIVDLKIVDIIGFIINPITRFVFNVSGKSALAFAISTVSGYPVGV
                     SLASEFRSNGQISKYEAQRLVSFCSTSGPLFIIGSVGTGMFQNSNLGYLMILCHYLGT
                     ILVGLFFRNYGNENLPKTKLDLKTNIKNVINIRNSSGNGFFVLFGNAVFNGVNTLLTV
                     GGFVIVFSVVFKILSLFNVISLIASVIYLPLSFLGVSKELCQAFVSGLFEITIGCNKV
                     SSITSSPEILRASLASFLIGFSGLSILAQCCTFLSKTDIDLKLYILSKFAHGVLAAIF
                     IFILYPIANSAVLVSSFADTYNVIYNNLIWFYYLSYYDTILQIVVIIYLISAVFIAKK
                     HMKTLSTNGKLMRYKNTFFTKKFSRKK"
     gene            15387..16100
                     /locus_tag="KRO40_000181"
     CDS             15387..16100
                     /locus_tag="KRO40_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBH2091026.1"
                     /translation="MFNSIASKKVYEQVIEQIQYKILNGELKKGDKLLSERELSEQMN
                     VSRTSIREAIRVLETMGVIESRQGEGNFICTNIEKTLIEPLSMIFKLNNGTLEDILEL
                     RIILEIEIAKLASKRITSSEVIELKHIIDEMRVETNKKDNNRVLVLLDQKFHSKLATL
                     SKNYLIQSLFMTASKLFDGFIEDAREKIIAEPFNENILLKQHEAIYNAVVENDVELAC
                     EKAKEHMDFISKNYRKNEN"
     gene            16218..17492
                     /gene="larA"
                     /locus_tag="KRO40_000182"
     CDS             16218..17492
                     /gene="larA"
                     /locus_tag="KRO40_000182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel-dependent lactate racemase"
                     /protein_id="HBH2091027.1"
                     /translation="MVKLKVPYSKQGMILEIPDERFLGVLESKSDNYIEHKTQEEIVE
                     ESMNNPIGSNSLEELVKGKKNVVIITSDHTRPVPSRITMPIILRRIRNVNPEIDVKII
                     VATGFHRPSTREELIYKMGEEIVDNEDIVMHISTDDKSMCKVGILPSGGDLYINKLAY
                     EAELLIAEGFIEPHFFAGFSGGRKSVLPGIASAKTIMYNHCSDFIDSDNSRTGKLNNN
                     PIHEDMVYAAKVAKLAFILNVVIDKDKKIIASFAGDVEKAHTKGCRFVTELSKVNSIK
                     SDIVVTTNGGYPLDQNIYQSVKGMTAAEATCKDGGVIIMISACNDGHGGQSFYENVAN
                     ADSPKQLLDKIRSVDRVDTIPDQWEFQILARILSKYTVIMVTDKCNPEMIKKMHMKHA
                     FNFKEALEMANSIVGKESKVVVIPDGVSVIVK"
     gene            17509..18297
                     /locus_tag="KRO40_000183"
     CDS             17509..18297
                     /locus_tag="KRO40_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003457975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH2091028.1"
                     /translation="MEILTCIKQVPGTTSVEVDETTGVLKRDGVDSKMNPYDLYALET
                     ALRIKEDKKANLKVLSMGPPQAKKVIEESFMMGADEGALISDRRFGGADVLATSYTIS
                     QGIKKMGKVDLIICGKQTTDGDTAQVGPEVAEFLDIPHVTNVTKLIEVKDESIVVEID
                     MPNDLQVCEIEYPCLITVEKDIFQPRLPSFKLKLNTKDREIPVYSLDDFEDKDENNYG
                     LNGSPTQVVRIFPPKPNTDKNIVRGNADELSFALVNKLEELKLV"
     gene            18311..19531
                     /locus_tag="KRO40_000184"
     CDS             18311..19531
                     /locus_tag="KRO40_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding protein"
                     /protein_id="HBH2091029.1"
                     /translation="MSKIVVNQDKITDLKRILEICPFGAIEEKSGIVEISAGCKMCKL
                     CVKSGPKGAFEFIESSKVQINKDEWRGIAVYVEHHNGNIHPVTYELIGKAREMASKIK
                     QPVYCVFVGKDIKDKCSNLISYGVDEVFVYDEDEFKDFRIEPYSKAIENFIDKIKPTI
                     VLVGGTTLGRSLAPRLAARFRTGLTADCTILDIQSNTDLDQIRPAFGGNIMAHINTPN
                     NRPQFATVRYKIFSAPEKIENTTGKITLCKVEKKELKSKIKVLSVKEKNKEVGLEEAE
                     VIVVASRAIKKQEDMEMIYKLADKLNAQVAGTRPVIEAGWIDAKKQIGLSGRTVKPKL
                     IITCGVSGAVQFVAGMQGADYIVAINKDDKAPILDVAHLALIGDIYDIIPKLIEKIEN
                     NKDNNQKYMASAAK"
     gene            19542..20933
                     /locus_tag="KRO40_000185"
     CDS             19542..20933
                     /locus_tag="KRO40_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBH2091030.1"
                     /translation="MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYP
                     EVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLVGAAVAINGGIMINLCKMNKILE
                     VDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
                     VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPL
                     PKKSISLLIPFPDLSMAIETVPKIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTS
                     DAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERNDSIWSARGAFLEAI
                     KASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMD
                     DNTWKIRLKETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLA
                     FDPKNILNPGKIY"
     gene            complement(21196..22476)
                     /locus_tag="KRO40_000186"
     CDS             complement(21196..22476)
                     /locus_tag="KRO40_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HBH2091031.1"
                     /translation="MNILGLIVEYNPFHNGHIYHLSKSIEKTNATHTVAIMSGNFLQR
                     GEPALFDKYTRAKIAVENGVDLVIELPTLFACQSAEIFSHGAITILNSLNCINSICFG
                     SEEGNTEILYNLAEILANEPNEFKLLLKKYLDDGLLFPTARANALFDYIHQDKKNNFI
                     QNYSKEQLSKTLNSSNNILGIEYIKNLIHLNSSIKPFTISRVQSEYNSEEIESDICSA
                     TAIRTSLKENTDLFHLKNVIPEKTYNILNEKIDNGFLPMFDDFFFDILKTIILRDMDT
                     LKEYFEVNEGIENRIYKDIFTSEFLHELQLAIKSKRYTLTKIKRTLNNILLGIKKSDV
                     QLIKNIDTIPYIRILAFNDKGREILKEIKNKSEIKIINKFSNISFSLDDTIFKTLISY
                     DIKATNIYNSIYYKNNKDLVKGPMDFYTHPIYVK"
     gene            22939..24135
                     /locus_tag="KRO40_000187"
     CDS             22939..24135
                     /locus_tag="KRO40_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HBH2091032.1"
                     /translation="MKILVLNCGSSSLKYQLIDMNNEEVLCIGLVERIGIEGSILKHE
                     KAGRDDKYVVEQPMKDHKDAIALVLEAVAHPEFGAVKEMKEIDAVGHRVVHAGEKFAT
                     SVVITPEVEEALKECIDLAPLHNPANIMGIDACKAILPDVPMVGVFDTAFHQTMPKSS
                     YLYGLPHELYTKYGVRRYGFHGTSHNYVSQRAAEILGKDIKDLKIVTCHLGNGASIAA
                     VDGGKCVDTSMGFTPLEGLIMGTRCGDIDPAILPFLMRKEGLDADGLDKLMNKESGVY
                     GMTGISSDFRDIEDAAKNGDERAQATLEAYVKKVQKYIGAYAAEMNGLDVVVFTAGVG
                     ENGKAIRADIASNMEFLGMKLDKEANDVRGKETVISTADSKVKMLLIPTNEELMIARD
                     TLRLVK"
     gene            24228..24752
                     /locus_tag="KRO40_000188"
     CDS             24228..24752
                     /locus_tag="KRO40_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HBH2091033.1"
                     /translation="MKVSIEKINRKETDKIDLNFCEKIDTISYCDEIYKLVSPVNLKG
                     KVSKTNKGLYLDIDVNFTIVDNCSRCLKEVEIPLEYSIQGFLVKEEDYDEDEFEEFDP
                     FIFDGEEIDLIDIIEQTLDFNVPHKVLCSENCKGLCQVCGANLNEEECSCSEITNDEE
                     YIDPRFAKLKDLFN"
     gene            24777..24953
                     /gene="rpmF"
                     /locus_tag="KRO40_000189"
     CDS             24777..24953
                     /gene="rpmF"
                     /locus_tag="KRO40_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HBH2091034.1"
                     /translation="MAVPKRKTSKSNTKMRRAANSKMEATGFVSCPQCHEPKLPHRVC
                     PDCGYYKGKEVVSK"
     gene            25160..25717
                     /gene="fapR"
                     /locus_tag="KRO40_000190"
     CDS             25160..25717
                     /gene="fapR"
                     /locus_tag="KRO40_000190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription factor FapR"
                     /protein_id="HBH2091035.1"
                     /translation="MKKKSKAQRQKELIDMLKTDPFYTDEELSSLFDVSIQTIRLDRM
                     SLNIPELRERVKSIAETQSSKVKTLGVKEITGEIIDLSVGRLGISMLEVTQDMIYSKT
                     NTLKDTYIFSLADSLAMAIIDAPKVIMRVANVKSFKLIEQQDRLIAKAEVYRNIDKKH
                     YVKVVINNKAQEQIFRGKFIFEELD"
     gene            25728..26750
                     /gene="plsX"
                     /locus_tag="KRO40_000191"
     CDS             25728..26750
                     /gene="plsX"
                     /locus_tag="KRO40_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HBH2091036.1"
                     /translation="MKIVIDGMGGDNAPKSNVEGAVNAIKEYQVDLIITGDKDLLEKE
                     FSNYEFDRNKLEIVHTTEIIENEDKPVKAIRSKKDSSMVVALNLVKEGKADAIISAGN
                     TGALLAGGLFVVGRIKGIDRPCLCSAIPNVKRGMTLIADCGANADCKPKNLVEFAAMS
                     NIYSRKVLGLENPKVALANVGLEEGKGNDLVKRSYEEIKKLDLNFIGNVEAREVINAY
                     TDIIICDGFTGNILLKSAEGVALSVMSLIKETFMASTKSKIGALLIKDDLRKLKSFID
                     YSEYGGAPLLGLNGGVIKAHGSSDAKAIKNAINQGIKFSKGKVVEDINQFISKYNEEN
                     KNNEDE"
     gene            26776..27762
                     /locus_tag="KRO40_000192"
     CDS             26776..27762
                     /locus_tag="KRO40_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HBH2091037.1"
                     /translation="MNTKAGILGVGSYLPEQSYDNFHFEKIMDTSDEWISTRTGIKER
                     RFAKESEATSDLASKAALKAIECAKLNVEDIELIILATITPDMSLPSTACIVQDAIGA
                     VNATAFDISAACSGFVYGVTIAKQFVETGCYKNVLVIGAETCSKFLNYDDRTTAVLFG
                     DGAGAAVIGPVNEGGILSTHMGSDGKGKDCLKVPAGGSRLKASKETVEANLHTIEMAG
                     SDVFKFAVRKMAETSLRALEKANLNTTDIDYLVPHQANIRIIQASSKRLELDMKKVYV
                     NIDKYGNMSAASIPVALDEAYREGKIKKGDNVVLVGFGGGLTWGASVVKWTL"
     gene            27871..28800
                     /gene="fabK"
                     /locus_tag="KRO40_000193"
     CDS             27871..28800
                     /gene="fabK"
                     /locus_tag="KRO40_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HBH2091038.1"
                     /translation="MNKICKILNIKYPVIQGGMAWVATASLASAVSNAGGLGIIAAGN
                     APKEAIKKEIVECKKLTDKPFGVNVMLMSPFVDDIIDLIIEEKVQVITTGAGNPAKYM
                     DRLKEAGTKVIPVVPTIALAQRMEKLGATAVIAEGTEGGGHIGELTTMVLVPQVADAV
                     NIPVIAAGGIVDGRGIAASFALGASAVQVGTRFICSEECSVHSNYKNLVLKAKDRDAI
                     VTGRSTGHPVRTLKNKLSKEFLKMEQNGATPEELDKKGTGALRFATVDGDIEKGSFMA
                     GQSAAMVKEITPCKEIIEAMVNQAREIMPAIEL"
     gene            28816..29766
                     /gene="fabD"
                     /locus_tag="KRO40_000194"
     CDS             28816..29766
                     /gene="fabD"
                     /locus_tag="KRO40_000194"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HBH2091039.1"
                     /translation="MGKVALVFPGQGAQYVGMAKDLYENNTVAKSVIDEASDALNMDL
                     KNLMFNGNEEELSKTENTQPAMVTHSVAVLKAVQAQIDLKYNACLGLSLGEYSALVAA
                     DAIDFKDAVCLVKKRGKFMQETVPAGVGAMAAILGLDRNVLENVVKDIQGGIVEVANY
                     NSPGQIVISGENEKIEEAMVKCKEAGAKRAVKLNVSGPFHSSMLKEAGVKLASELEKV
                     NITKPKVDVVANVNADYYKNEGKDLLIKQVSSSVLWEDSIERLLNDGYDTFIEMGPGK
                     TLKAFIKKIASNKKANVNIYNIDGIDSLNEFVQNYRNGEI"
     gene            29766..30515
                     /gene="fabG"
                     /locus_tag="KRO40_000195"
     CDS             29766..30515
                     /gene="fabG"
                     /locus_tag="KRO40_000195"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HBH2091040.1"
                     /translation="MINLTGQVAVVTGGSRGIGKEIAKKLASFGADVVINYTSKEDEA
                     LKTKNEIESMGVKCTSIKCDVSKFDEVNQMIDSVVSEFGKIDILVNNAGITKDGLLMR
                     MKEEDFDRVIDINLKGVFNCTKAVTKPMMKKKYGRIINMTSVVGIMGNAGQTNYCASK
                     AGVIGFTKASARELASRNININAVAPGFIETDMTKVLSDDVKESTLANIPKKSYGKPE
                     DVANAVAFLVSDMSSYITGQVINVDGGMVMQ"
     gene            30569..30793
                     /gene="acpP"
                     /locus_tag="KRO40_000196"
     CDS             30569..30793
                     /gene="acpP"
                     /locus_tag="KRO40_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBH2091041.1"
                     /translation="MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMAL
                     EDEFGIEIPDTEAENFKSIGDIVKYIEANK"
     gene            30822..32060
                     /gene="fabF"
                     /locus_tag="KRO40_000197"
     CDS             30822..32060
                     /gene="fabF"
                     /locus_tag="KRO40_000197"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HBH2091042.1"
                     /translation="MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDAST
                     YQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVSAKLAVEDANLDLDKVDRERFGV
                     IIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
                     TACASGTHSIGDAFKVIQRGDADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTA
                     SRPFDKDRDGFVMGEGAGIVILEDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENG
                     EGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKTVFGEKAYDLCVSST
                     KSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYA
                     LSNSLGFGGHNATIVLKKYV"
     gene            32286..34004
                     /locus_tag="KRO40_000198"
     CDS             32286..34004
                     /locus_tag="KRO40_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2091043.1"
                     /translation="MNFRLPKKRLPKKIIFICIILISIILFIKYDQNGLKEREIINKG
                     KYMSESLVADKEYDEAKKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVID
                     SLEKMRESDVKLSDECRFNIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKA
                     RLDVDLASIFLKIGSYETGEKLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEEGEY
                     DKAIEISSRIKDYKKFVNTDNYNDFDIMASIMQSNAYVGKNNIQKAKTFLEKADYLIK
                     SDRTVYILDKDMYYYMAMGNLEYKSENYNSAIDNYKKSLEISTKRKLTQEKIKNLNKI
                     LNIYEKQGNIESLNEYQKMLINEYKENKSIRDSETSFYIIDKVSNESKLFEKTKKEIK
                     YYKILFTVILIAILGSTFLYNRLKYFKAQNLHDGLTNVYNRKSFDIMYEKYREKDDNF
                     ALVMIDIDNFKLINDNYGHKFGDTVIKGITNTICVMLEQDDKVFRYGGEEFSVLIRNK
                     SGEEVADIIDSIRVAIANKKWNDDVTVTISAGVAHISDSKDVLEEADKNLYKAKQLGR
                     NKVVYK"
     gene            34035..36035
                     /locus_tag="KRO40_000199"
     CDS             34035..36035
                     /locus_tag="KRO40_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2091044.1"
                     /translation="MKQSIAIVTDKITKLSSFLEENIRLVLGNYIDINHYYLEVLKEN
                     DKIQGDFVLVMNDDRLNSMRKHLVQDSKIIVIRRTLKENEIYGLFSIPNGTEVLVVND
                     TKETTLETISLFYKIGVKNLKFTPYIEGKIYKNIDIAITPGVKGKVPSYINKVIDLGN
                     RYIDISTFIEIINGLRIDVKEIRKNLMAYSESLISLDNGVKDNYRQLFLKIEEQDVIL
                     NLSKDGIIFTSADGIINTFNKEALKILGINENPQGKNIEDIISEDLNILLEDKEIIDE
                     VVFTNKKYINVNKKSIFSMGNKAGIYYNLQEITYIKKLEQNLTNKLREQGQIARYTFK
                     DIKTKNKNMVKCVELAKKISKSDLSVLIIGESGTGKELLSQSIHNASNRSNQPFIAVN
                     CAAVPDSLLESQLFGYEKGSFTGALREGKKGLFELANNGTIFLDEIGDMPPLLQTKLL
                     RVLQEKQVMPIGSHNVINIDVRVIAATNKNLLKMIREGKFREDLYYRLNVLPIDVPSL
                     RNRKEDIITLMNFFLKNNIRLSPEVITILEKYNWPGNIRELQNVASYVSLMCDSMVFR
                     DDLPPYIRVECANNYEDGFGYTRKEFEEILRILYERRESSSGIGRGFIIEKLIQEGIE
                     ISESKVRKVLSYLSECGYISSKSGRGGSQITSEGIKLYNNIN"
     gene            36386..36631
                     /locus_tag="KRO40_000200"
     CDS             36386..36631
                     /locus_tag="KRO40_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBH2091045.1"
                     /translation="MKYKTTGTCATEIEFEVKENKVTNVNFIGGCDGNLKGLKVLVEG
                     MNIEDVIQKLKGIECKTKPTSCPDQLSLALENYMNIK"
     gene            36666..37391
                     /locus_tag="KRO40_000201"
     CDS             36666..37391
                     /locus_tag="KRO40_000201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBH2091046.1"
                     /translation="MKPIIGILGNLIIMENGMFPGLERSYVNNDYINAVLKGGGSPVI
                     IPVNTDKEVIKKQIEMVDGVLISGGWDINPQLYGEETREETTFIYPEVDEFDLIAISI
                     ALELKKPILGVCRGLQILNVSLGGTLYQDNNLIEGSYIKHTQSSKRHVATHKVDVKEG
                     SILEGILGKQLLTNSYHHQSVNQLGKGLKAIAYSKDGIIEAIEKEDENFVVGVQWHPE
                     MMVDYCDKMEKLFKYFINICSNL"
     gene            37413..38726
                     /locus_tag="KRO40_000202"
     CDS             37413..38726
                     /locus_tag="KRO40_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2091047.1"
                     /translation="MNEKNKMGLISIILLGINAVVGAGVFLLPGDAMKSFGVASIFVY
                     IFDMLLVLSMAFCFAEVAGKFNKNGAAYVYTKEAFGDFCGFEVGLMKWVIGCISWGAL
                     IVGFPTSLSAVWAPAGEPHIQKIIIVAMIVGLTIINLLGVSLSKIVQNVITVGKLIPL
                     ILFIGIGIFFIKGVNFTSSTMVPPGAGATEFGAAALLMFYSFTGFESIAVAAEDMENP
                     QKNIPIAIISVIVIASIIYILNQVVCVGILGDSLSSTSTPVADAARICFGNMGAGLVT
                     FGTLVSVGGICMCGAFVNPRSCVALADDKMLPRIFARKDKKGTPYVAIIATMLITIPI
                     ALSGSFAELAAISAVARFIQYIPTSLSVLVFRKKRPELVGTFKTPFGAVIPLIAVCVG
                     TWLLFQASMHQLIMGLGALAIGVPLYFIMKSYNRKIYGENLKKIV"
     gene            38932..39471
                     /locus_tag="KRO40_000203"
     CDS             38932..39471
                     /locus_tag="KRO40_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091048.1"
                     /translation="MPTITLKNGVDVLIREGVREDAQSIIDFYNEVGGETHFLSFGKD
                     EYKISLEEQENAIESAKASDNSVKLIAFIDGEIVGIATIDSNQKAKGKHVGVLGIVVK
                     EKYWGIGLGKRLMLDLIEWCKSNGITKKITLVTNEENYNAIGLYKKVGFEVESILKKE
                     CYYNGVYTDLIGMSLLLGI"
     gene            39560..41545
                     /locus_tag="KRO40_000204"
     CDS             39560..41545
                     /locus_tag="KRO40_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="HBH2091049.1"
                     /translation="MKNLCKISDDYLNSKLKYLKLLSKQYPSISKASTEIINLEAILN
                     LPKGTEHFITDVHGEYEPFVHVLKNGSGVIKRKIEELFSNTIRDSEKKMLATLVYYPE
                     QKLDLIIKQEENIDDFYRINIYRLIELCKYASSKYTRSKVRKLLPENFKYIIEELLHE
                     HVKSEHKEEYYKSIVETIVDIGIAKEFIIAISTVIQKLVVDRLHVIGDIYDRGPRPDI
                     IVDKLIEHHCVDIQWGNHDILWMGAASGEKTCIANALRISARYANLDIVEDIYGINLL
                     PLATFAIEMYKDDPCKEFIPKVNDQSVTTTEKSLMAKMHKAISIIQFKLEGEVIRRRP
                     EFEMEHRLLLNMINYDEGTINLKGKTYKLKDTYLPTIDKKDPYKLTMEERNVIDKLVS
                     SFRGSEKLQKHVSFLFSKGSIYLKANSNLLIHGCVPLNEDGSFMSMNIMGKEYKGKAL
                     MDKMESLAREGFFFKDKAEEKLYGMDIMWYLWTGKCSSLFGKDDMTTFERYFIAEKET
                     HKENKNPYFKLRENEMACKRLFEEFDLELDESHIINGHVPVESKNGESPIKANGKILV
                     IDGGFSRAYQKTTGIAGYTLIYNSRTLQLVSHEPFNSAEEAIANESDILSTTVVVEHK
                     AKRKMVRDTDEGIKIQEEIEDLKLLLMAYKKGLIKEM"
     gene            41769..42737
                     /gene="spoIIIAA"
                     /locus_tag="KRO40_000205"
     CDS             41769..42737
                     /gene="spoIIIAA"
                     /locus_tag="KRO40_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AA"
                     /protein_id="HBH2091050.1"
                     /translation="MNKLSDEIINSLSTTIREKVEKVSNNNLNIEEIRLRSQKPLILN
                     ANSKDYFYNQKTMTLDLNQQNSYVVTREDVEQTFQIICKYSIHSFMDDIKKGFITLRG
                     GHRVGLVGKAIVEDGQVKNIKHISSLNIRVSREIIGCSDKILSHIIKGKNQINNTLII
                     SPPQCGKTTLIRDIVRNLSNGNEDYGFKGLKVALVDERNEIAGAYLGVPQMDVGIRTD
                     IIETCPKDLGITMLLRSMSPNVIVTDEIGSEKEIKALYTALNGGIGLITTVHGDSIED
                     IQNRKELNRLLDKELFKKVIILSAKRGAGTIEKIYDLEEKRWYFAN"
     gene            42727..43248
                     /locus_tag="KRO40_000206"
     CDS             42727..43248
                     /locus_tag="KRO40_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AB"
                     /protein_id="HBH2091051.1"
                     /translation="MQIKIIIIAFLIGSSYLIGEQIYKTYTRRHKQLNDLIRVLEILR
                     MDLSFGLYTLEEIFNRIGGNKEFCFWKFFYQISEGLHNEQSKTLEIIISENIDVLSKE
                     TYLGNKEIEELKNLILTLGKSDIESQQRMIDLSIENLKKQTYETKEDINKKGVLYKKL
                     VTFIGIGICIILI"
     gene            43265..43462
                     /gene="spoIIIAC"
                     /locus_tag="KRO40_000207"
     CDS             43265..43462
                     /gene="spoIIIAC"
                     /locus_tag="KRO40_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AC"
                     /protein_id="HBH2091052.1"
                     /translation="MEISLILKVAGVGILISVLNMILEKTDRKDWAGLTTLAGVIIVL
                     GMVITEISDLFNTVRTMFQLY"
     gene            43478..43864
                     /gene="spoIIIAD"
                     /locus_tag="KRO40_000208"
     CDS             43478..43864
                     /gene="spoIIIAD"
                     /locus_tag="KRO40_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AD"
                     /protein_id="HBH2091053.1"
                     /translation="MEIMQLIGIAIISTTLCLVIKKDRPEIANFIAIITGVIILLSVM
                     FKLNFIVDSIQDLANKANIPTMYISLIIKLIGIAYLMEFAIQLCKDCGEGNIASKLEF
                     GGKIIVMSMSFPILLSIVEMVVNIIP"
     gene            43949..45154
                     /gene="spoIIIAE"
                     /locus_tag="KRO40_000209"
     CDS             43949..45154
                     /gene="spoIIIAE"
                     /locus_tag="KRO40_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AE"
                     /protein_id="HBH2091054.1"
                     /translation="MKKRFLPMIIGFLFTFFFVNIFAIMIFANEVPSSEDKEYGETKN
                     SIDKYIDGQLDKLDINEIQDYINKEIVINDVNLKSFVKDLISGEKNILDLFNKDGLKI
                     LMFDEFKASLKVVAVILVLALLSSILKSLENSFSSGAVSQIATYIIFITMVSLTLIGF
                     KDVLQICYDAIDHTVGLMQVIMPILITFLLLIGFPITSTTLNPIFIGGVTFINVFFKN
                     FLFVSITVAFGILIINNLSKNIRLKRFFSFVKQINYVSIGAMFTVYLGLVSIQGLYVT
                     SFDKFSVKTAKFAIGNFIPVVGGFVSDSVDILLSSSQLIKNIFGGIGLILLVGICLLP
                     VIKILSVIVVYKLAAIIVEPVGEDGISNFLNEVANLMIIMLASVIAITVMFFVTVAIL
                     TSISVVSQG"
     gene            45214..45831
                     /locus_tag="KRO40_000210"
     CDS             45214..45831
                     /locus_tag="KRO40_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AF"
                     /protein_id="HBH2091055.1"
                     /translation="MLEGIKAWIVSVLIGAFIVNIVDMILPSSKIKPYVNLVLNFMFV
                     FIVITPVVGFFSKDMSLEDRILKSMGNYNKQYVDSTNALAKETGNNSLSKGYEDGLKE
                     VLKLKLDEYGYDLEDIELNGANINNIKIKEKNNSAKSNNSSNEENKNNSTKREEENIN
                     SNDKENSKQVFKKGTEYGLNLNEEKLKNDLIKVLDVSIEDIQIDK"
     gene            45843..46397
                     /locus_tag="KRO40_000211"
     CDS             45843..46397
                     /locus_tag="KRO40_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AG"
                     /protein_id="HBH2091056.1"
                     /translation="MLKNLNDKDKRKVYSLITIAGICVVSLVLLSCFPSSKSDKQVGK
                     TETNKNAEKQVTKEQEKDDLESKLTAILSKIDGAGDVDVMVTFESSEEIQPAFNSNNT
                     TETTEEKDAQGGERTVTTSSENKTMITSNSSDPVVIKTTEPKIKGVIVVASGASDPSV
                     KETLYSAVQTSLQVAGHQVEIYSK"
     gene            46424..47113
                     /locus_tag="KRO40_000212"
     CDS             46424..47113
                     /locus_tag="KRO40_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIIAH-like family protein"
                     /protein_id="HBH2091057.1"
                     /translation="MKFNYKGRGFVIITLTAMLVVVGTVNYQLSKKSLLETSKEFKAY
                     EEAQLQKNTDESDSSKTEDSSNIDKQDGKESADIDIVDSKASKVKEKATETSKEIKAQ
                     LSSEKNMKKASYILDMKMNREKQRNELVQDLNEMINNPSTTEESRKEASNMKLNIVKI
                     QEKELQIENLLSTKGYEEALVYISDNKVNVVVNEAKLEKKDAAKIFDLVAEQANVKYE
                     NIKLTNNNSNK"
     gene            47223..47585
                     /locus_tag="KRO40_000213"
     CDS             47223..47585
                     /locus_tag="KRO40_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBH2091058.1"
                     /translation="MEDNKFGQVKISNDVIATIAGLAALEVEGIETTATLTDKLLKNN
                     GVKIQIEEEDVNLDVMVTIKYGMSIPDTAFKVQENVKNTVETMTGLKVSQVNIHIQGI
                     SFKKDKVDKEEAKATKKN"
     gene            47670..48176
                     /gene="nusB"
                     /locus_tag="KRO40_000214"
     CDS             47670..48176
                     /gene="nusB"
                     /locus_tag="KRO40_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HBH2091059.1"
                     /translation="MKKDRAQKSTTREYIMKLIYQININKEDFETLEDKVDNFLKDNS
                     EHIINRYKELALQYSKNTNLKLEDTEIEDVIDKKYINTVCKALKENHDKIDELINKHA
                     KNWTVDRMPKVDVSILRLSVCEILYLDTPNKVSINEAVELAKIYCDDKSPKFINGILG
                     SVVDEIGK"
     gene            48160..49230
                     /locus_tag="KRO40_000215"
     CDS             48160..49230
                     /locus_tag="KRO40_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-sialoglycoprotein endopeptidase"
                     /protein_id="HBH2091060.1"
                     /translation="MKLGNNIIIGIDTSCYTTSIAAISLDKKVIFNEKIMLEVRDNSK
                     GLRQSEAVFQHINNLGILSDRIKSFKDKFNVEGVCSSKKPRPVENSYMPVFNVGHNFG
                     KLLSSIYGCRFYETTHQENHIEASLLNSKLKNNNKFISVHMSGGTTEILLTSKQDSHH
                     NVCDTNLGKIAKISIKKDDKSKLYNNFGYNIDIIGGSKDISFGQLIDRVGIKLGYKFP
                     SGKYLDENALNCNLKIESGLKTSVRDGYMNLSGLENQVNKIINDNGYNTNQKEYISKL
                     VLDSVVRNMFKSLVYLCETYNVNEVVFAGGVSASKYILRELSVKLRKKHIEAYFTEPQ
                     YSTDNAVGCAIIGLNNFLGERV"
     gene            49227..50432
                     /locus_tag="KRO40_000216"
     CDS             49227..50432
                     /locus_tag="KRO40_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HBH2091061.1"
                     /translation="MKLRALDISEANSYIKRILINDPILSNLKVKGEISNFKVHSSGN
                     VYLSLKDETSKLNCVIFKSNFNRNLKLDNGVKIIANGYISVYERDGAYQLYINEIEIE
                     GIGNLHIEFNRLKEKLNKEGLFDPKYKIPIPKMPNSIGVITSPTGAVIRDIINVIKRR
                     YPKVNIKLYPVTVQGDKSAEEICEAIRFFNHMKNVDTLIVGRGGGSIEELWSFNDEMV
                     AREVFNSQIPIISAVGHETDFTICDFVSDMRAPTPSAAAEIATPSLDDINYKLGNIKS
                     RMSKSLTNQIELDQYRLETVFNKINNYLDSYTIKDKVIQLDKIYDKIIFGIENNLKLE
                     DEKLVKIGALLHNLSPLATMDRGYSITQKNGKVINSIKGLKIKDSIDIVLKDGNLECM
                     IDKIENKEG"
     gene            50434..50649
                     /gene="xseB"
                     /locus_tag="KRO40_000217"
     CDS             50434..50649
                     /gene="xseB"
                     /locus_tag="KRO40_000217"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HBH2091062.1"
                     /translation="MNLTYEEAYKRLESILSELESKNASLDESLSLYEEGISLYKHCN
                     KLLDDAKLKISKFNQLGIEEDFKIEEE"
     gene            50652..51539
                     /locus_tag="KRO40_000218"
     CDS             50652..51539
                     /locus_tag="KRO40_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HBH2091063.1"
                     /translation="MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGG
                     KRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYSLIHDDLPALDNDDLRRGRPTNH
                     KVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
                     DVESENKQIEKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSF
                     QIVDDILDIVGDEAKLGKKVGSDIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKL
                     SDDVDFLKGLAEYIIDREY"
     gene            51569..52006
                     /locus_tag="KRO40_000219"
     CDS             51569..52006
                     /locus_tag="KRO40_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divergent PAP2 family protein"
                     /protein_id="HBH2091064.1"
                     /translation="MDFFSEIFNNGALGISLIACFLAQFIKIFTGKEKRIELSRILIS
                     GGMPSSHSSFVTSLATVVGIEKGFNSTDFAIITVLALIIMYDAAGVRRAVGKQATILN
                     QMVADIQHGKHIEQKKLKELIGHTPLEVWFGALLGIVTALILM"
     gene            52040..53905
                     /locus_tag="KRO40_000220"
     CDS             52040..53905
                     /locus_tag="KRO40_000220"
                     /EC_number="2.2.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="HBH2091065.1"
                     /translation="MYKYLDKVNSPKDIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHL
                     ASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHKIVTGRKDCFVSLRQFNGLSGFP
                     KENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
                     LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEI
                     LSKTAHRFKDKLMYSFSPQDCSFFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVL
                     LHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSISVGEKLVDMANSNEN
                     IVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFL
                     QRAYDQVIHDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDT
                     REMELMMDLSLKLDCPLAIRYPRGSSYYLDKGEYGEIVLGKYEVLDDGQDTVILCIGS
                     MVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNIVTGGFG
                     SRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE"
     gene            54038..54850
                     /locus_tag="KRO40_000221"
     CDS             54038..54850
                     /locus_tag="KRO40_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family rRNA
                     (cytidine-2'-O)-methyltransferase"
                     /protein_id="HBH2091066.1"
                     /translation="MKKRIDLLLVEQGYFESRERAKKAIMAGLVFVDNQRCDKAGTEV
                     KEDCSIEVKGNPIPYVSRGGLKLEKAMKNFDLTIDGKVCMDIGASTGGFTDCMLKNGA
                     IKVFSIDVGYGQLAWKLRQDDRVVCMERTNIRNVTIEDTKQFADFASIDVSFISLKLV
                     LPKAKELVRHDGEVVALIKPQFEAGREKVGKKGVVREKSTHIEVIKMISDFSVENGFE
                     ILGLDFSPIKGPEGNIEYLIHLRNGNEGYEFDGETYNNKIVEVVEASHNLDK"
     gene            54870..56549
                     /gene="recN"
                     /locus_tag="KRO40_000222"
     CDS             54870..56549
                     /gene="recN"
                     /locus_tag="KRO40_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HBH2091067.1"
                     /translation="MILELYMKNCALVEELRLNIDKNLNILTGETGSGKSIIIDALGL
                     CLGDKYDRSFLRKGTDKGLVEAVFFSDNRYLKKILEENDISMEDDNLLVITRLIYSDG
                     KSTARVNGRTVKVSLLKEIASTLIDIHGQHQNQALFNKDTHLKFLDLFGENELEEFKI
                     AYKNVYHKYSEVKKALNCLTENKDEMQIQREIDLLRFQINEIEAANLNKNEYEDLLKQ
                     REVYRNSEKIYNNLNSSYSKLHNGEYNVIDLIGLASKELNDISKYDSVLSEYSDTVER
                     IMYELQDISGEIRNYKDNIDFEPYELEQIELRIDEINNLRRKYGDSIDDIFEYYGKIK
                     DRLDEILNRDERVEQLRSKLMNIEEDLKIKASKLTKARIEVATTLEKILLDELKSLNM
                     KNVMFKVNFEKGPFTLDGVDDIEFMISFNLGEDIKPIYKVASGGEMSRFMLAFKTILA
                     DIDDIDTLVFDEIDTGISGIAAQIVGEKLSDIAKKKQIICITHLPQIAANADTHYCIE
                     KDTSNNRTFTNVSKLNESQRKNEIARLIAGNNITEKTIEHASEIIELAKKC"
     gene            56763..57629
                     /locus_tag="KRO40_000223"
     CDS             56763..57629
                     /locus_tag="KRO40_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091068.1"
                     /translation="MNKKDTMHLIFTIVIFILLWYIVVAVSEINKNIESCSNKLDYLS
                     QEIMSTKSDISNTINEEMSKSYITKSIDLKVKKIEKKECVIDVDVQLSKLGKNGKVFF
                     MYKEDSDKWNETEMTKHGELSYACEIKINTGSEYDYKVVTSGAISESSDVQKLTKSDY
                     MPEQPIFNSGIRDNREYFIEIVENSNLFNHESEKSKNKVYDNIRLEKVDIIVNEGKKD
                     TIYKAKLAEGLDDGKTNNSNRNQVNYEVSFPKRDIDDIIYIKAKLTYNNGVEYTKDIT
                     EDITMGLQDLEK"
     gene            complement(57722..58213)
                     /locus_tag="KRO40_000224"
     CDS             complement(57722..58213)
                     /locus_tag="KRO40_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091069.1"
                     /translation="MADKMAQNITLQFVEEKDLENLENVKLLFTEYSNSLNIDLCFQD
                     FNNELKTLPGKYKKPSGSLILAFVDENLAGCVALKKLEGKICELKRLYVRNQFRGLKI
                     GKILLEEIIEEAKKFGYTHMRLDTLPSMKSAQGLYEKFGFYDIEPYTYNPIEGARYME
                     LKL"
     gene            complement(58274..58714)
                     /locus_tag="KRO40_000225"
     CDS             complement(58274..58714)
                     /locus_tag="KRO40_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091070.1"
                     /translation="MKLNVRIADINNWHDLVSLSVDKSQLDYIESNALSIAESKFITA
                     WVPVGIYDENSLIGFAMYGRLEDDRVWLDRFMIDSKYQGKGYGKASLDFLVNHLKNEY
                     NCDELYLSIFEDNKMAIKLYKDFGFEFNGELDYGGEKVMVLKSN"
     gene            58875..59933
                     /locus_tag="KRO40_000226"
     CDS             58875..59933
                     /locus_tag="KRO40_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBH2091071.1"
                     /translation="MNKINKNFKNIWIILGAVSIFTMVIIFNKNCNVNKETQIEAFTI
                     KNHDKKFVYPMGNIIGVKANTDGVLVLGYEEEDVDYIGGIQIGDNIVKIDNKRIKNSQ
                     DVSEILNKIKKSKVEVTFERKNKYKTEVIETKKENGKYKLGLWVRDKISGIGTMTFYD
                     PSMEKFKAIGHAIKDSDTNELLKIKQGYIYKPEQLKIVKASNEKVGKIKGDFNDSNLM
                     GNFSNNSELGISGNITENHNKEFNVANKEKQLIEVGRPQDVKIGDAVILFEDKNKNIT
                     SYDIKIESIVYDKGNYRDMVIKVVDDKLLEYTGGIVQGMSGAPIIQNNKIIGAITHVF
                     RDNPKKGYGIFIDEMIKL"
     gene            60075..60899
                     /gene="spo0A"
                     /locus_tag="KRO40_000227"
     CDS             60075..60899
                     /gene="spo0A"
                     /locus_tag="KRO40_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="HBH2091072.1"
                     /translation="MGGFLVEKIKIVLADDNKDFCQVLKEYLSNEDDIDILGIAKDGI
                     EALDLVKKTQPDLLILDVIMPHLDGLGVIEKLNTMDIPKMPKIIVLSAVGQDKITQSA
                     INLGADYYIVKPFDFVVFINRIRELVSNRVTQVEPKPRPVQETQMTRSDFVKNVGNIE
                     TEITNIIHEIGIPAHIKGYLYLREAIKMVIDNVELLGAVTKELYPSIAKKFNTTPSRV
                     ERAIRHAIEVAWSRGKVDTINQLFGYTVHNTKGKPTNSEFIAMIADKLRLEHSMVK"
     gene            61312..62433
                     /locus_tag="KRO40_000228"
     CDS             61312..62433
                     /locus_tag="KRO40_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091073.1"
                     /translation="MRVEAPIKVDRKTKKLAKRVESGEIAVINHIDIDEVAANSLVEA
                     KIKLVINAAPSISGRYPNKGPGILTENNILIIDNVGEELFEELKEGETIEVVDGKIYR
                     KGKFLGAGEVLDKYEVSHQIKAAYENLAVELDRFIDNTIDYAKKEKGFILGEVEIPKV
                     KTNYANKHVLIVVRGQDYKEDLSTMLSYIEEVKPVLVGVDGGADALIEFGYTPDVIVG
                     DMDSVSDEALKKASEIVVHAYTDGRAPGLKRVEELGLDAVVFPAPGTSEDIAMLIAYE
                     YKAELIVAVGTHSNMIDFLEKGRKGMASTFLVRLKIGSKLIDAKGVNLLYRSKLKIKY
                     IWALIATALFPVLVVASLSPGVQQFIQLMQLKFRVLLQM"
     gene            62451..63326
                     /locus_tag="KRO40_000229"
     CDS             62451..63326
                     /locus_tag="KRO40_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper transporter"
                     /protein_id="HBH2091074.1"
                     /translation="MHINMKYYIVTIGAIFIALGIGMLVGFNLNNNQQLSEQQANIIN
                     DLDDKFDILKEKNDKLDSDLASVNRDYEEAVNFINKNVDKILAGSLNGKSIGIISANE
                     NDDYTKNIEDIINKSNGSIAFNIILKENITNPEKLKEMSTKLGTDVKNANDAVNYIID
                     TLKKEDASDILTYLQELDVIKFNFIGDTYLKYDSVVIAGGNDAKDSAKQFEKIEKFVV
                     SKLKSENKYLVEVQNTGVKTSYVELYSKNKVATIDNIDEGIGSISLAILLQQGNIVGN
                     FGRLDTATSLLPSIK"
     gene            63350..64042
                     /locus_tag="KRO40_000230"
     CDS             63350..64042
                     /locus_tag="KRO40_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2091075.1"
                     /translation="MDSYISIIIPAYNEESRIKYTLESILDIKQINEIIVVDDGSIDN
                     TAKVVSELENEKIKFFKLDKNRGKGYALNYGIKLAMKNADIIGFLDGDLGSSAKEVEK
                     LIVPILNGEADVTIAKFPPAKRKGGLGFVKGLAKNSVFEMTGVELDATLSGQRIFKRE
                     VLEKFDEIPFGYGVEVGMTIDILKYGFKIKEVLVNMTHNETGRNLKGFIHRGKQYYHI
                     KKVLGQKKKEWR"
     gene            64050..64874
                     /locus_tag="KRO40_000231"
     CDS             64050..64874
                     /locus_tag="KRO40_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH2091076.1"
                     /translation="MKDYILYTILLLTGLFGTYAVIPLFKNLLINGNVLRPNYKKDMI
                     PVSMGIVFLPMIVINGIILAFFTTEFKDLAYIFMFMFGMISMFFAGILDDVIGNRDVS
                     GLKGHFKSLFKGSLTTGGFKALFGGFVGLIVSVAISKDIIDIIVNTLIIALSTNLMNL
                     LDLRPGRAIKAYLFIMVIIFLTLTGFVQVLPLLIVPNVLAYFNYDLKARAMMGDTGSN
                     VLGISIGMLISFGYPFNIRLGWLIFVVIMHIFTEKYSLTKIIEKNKLLNFIDKLGR"
     gene            64879..65946
                     /locus_tag="KRO40_000232"
     CDS             64879..65946
                     /locus_tag="KRO40_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3866 family protein"
                     /protein_id="HBH2091077.1"
                     /translation="MISKRVGIVESIVSQTETLDDIRVNINGEIQKAYNYPKISGTIN
                     IGDEVVLNTTAVELSLGTGGYHFVITNLNNIESTLTEGGHIMKLRYTPLQIKVDSVEE
                     QESIYHDKFANFKGLEGLSVVVGTLHSMLTPFAASFKRNNPNKKLVYIMTDGASLPIY
                     LSKNVDTLKEKKLIDSTITIGNAFGGDYECINIYTALITAKEILKADAVFVSMGPGIA
                     GTGTKYGFTGIEQGSILDAVKKLEGRAIAIPRISFADKRERHQGISHHSMTVFKEIVN
                     VNVDIPITIYDDEKLNFIKEQINLNGLDKKHNIIYIDNNKTKEDLDYFNLKVKSMGRN
                     YEQDEAFFKAASTAAYYLMEV"
     gene            65948..66484
                     /locus_tag="KRO40_000233"
     CDS             65948..66484
                     /locus_tag="KRO40_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH2091078.1"
                     /translation="MVLEEKTISSDRVYTGKVITLKVDTVEIPGQGYQKRELVEVGGA
                     VGIVAITDDNKVVLVKQFRKPIEKPIFEIPAGKLEKNESPKECAERELKEETGYSAKN
                     IKLIHKFFTSAGFSNEIMFVYLATGLTPGENNLDADEFLDVYEIELEEAYNMVLKNDV
                     EDAKTSIGLLLVKDMFKN"
     gene            66552..67157
                     /locus_tag="KRO40_000234"
     CDS             66552..67157
                     /locus_tag="KRO40_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein M"
                     /protein_id="HBH2091079.1"
                     /translation="MRRTYRKNDFRELNRQIIIIGLLFMMSIVVGSYINKILPGSSNN
                     ILNNINPAVEYYNLNISIKDTVIQNLKSDAIFMGSIALLSLFVVTIPAVLVAFVLKGM
                     SIGYTINSCILALKFKSIKMILIILFKNLIIIPCAIILALISLSYFKEMVYEFKKKNR
                     KNMQFLIKRYILNIIIIIALSLGLQLILNTASIGIIKFLAK"
     gene            67169..68083
                     /locus_tag="KRO40_000235"
     CDS             67169..68083
                     /locus_tag="KRO40_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH2091080.1"
                     /translation="MDIIEGYIDYIKDKKKLSENTVASYFMDIKKYMEYINQKSIKLV
                     DIVENDIISYLIKLEKDNVSIATIARMISSIKSFHDYLFLNHICTNNPAKDIKKPKIK
                     KENINILTEEEIERLLNFPKLTTPKLIRDKAIFEVLYGTGIKVSELVEMNIEDIDLDI
                     DYIYCNSCCKNQRVIPLCDITKLYLEKYLKEARPKMAVEGEKSLFVSSLGQRFTRQGL
                     WKVIKKYSNLANIDKNINPTMLRHSFAIHLLNEGANIAVVSKILGNVNLSSLQVYLNH
                     IDKNVRREIKEKHPRNDVDVELQKAEAK"
     gene            68125..69297
                     /locus_tag="KRO40_000236"
     CDS             68125..69297
                     /locus_tag="KRO40_000236"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HBH2091081.1"
                     /translation="MSRVIWIVIDSVGIGALPDAEKFGDSKDVSTLGNIFKEYPDIQI
                     PNMRNLGIGNIDGIDFFESIKEPIGCFGKCKEMSQGKDTTTGHWEMTGIIVDKPFKTF
                     EHGFSKEIIEEFEKKTGRKVVGNKPASGTVIIDEYGEHQIKTGDVIVYTSADSVFQIA
                     ANEEVIPLEELYNMCKIAREIMMGDNAVARVIARPFIGKKKGEFVRTSNRRDYSLDPF
                     EPTVLDNIKESGLDVLAVGKIEDIFNGKGITDAIHTKSNMDGVDETLNYMKQDNKGLI
                     YSNLVDFDSKYGHRRDPEGYKKALEEFDSRLPEIMANMREDDILIINADHGNDPTYKG
                     TDHTREYIPVMIYGNKIKKGFNLGVKDTFADIGATVADILNVKLPKHGSSFKEDLF"
     gene            69344..70156
                     /locus_tag="KRO40_000237"
     CDS             69344..70156
                     /locus_tag="KRO40_000237"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HBH2091082.1"
                     /translation="MFEKIAQSSKFINSKSDIKPKIGLILGSGLGDLANDIEDPVAIK
                     YSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELG
                     VEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
                     KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETPAEVRMAQILGADAVGMSTVPEVIVA
                     SHSNIGVIGISCITNMAAGILNQPLSHEEVIETTQKVKSEFMNLVKTTVKNL"
     gene            70360..71685
                     /locus_tag="KRO40_000238"
     CDS             70360..71685
                     /locus_tag="KRO40_000238"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HBH2091083.1"
                     /translation="MRMYDIIKKKRDNLELSKKEINYFIENYSKGDIPDYQASALLMS
                     IYLNKMNKQETVHLTEAMMNSGDMINLSEIDGIKVDKHSTGGVGDKTTIALIPLVASC
                     GAPVAKMSGRGLGHTGGTIDKLESIPGFSTEMEISKFIDSVNKSKIAVCGQSAKVAIA
                     DKKIYALRDVTATVDNISLISSSVMSKKLASGADAIVLDVKTGDGAFMKTLEESFELA
                     KSMVDIGTGMNRDTIGIVTDMDEPLGFAVGNSLEVIEAIETLKGNGPKDLVELCEVLG
                     AYMLVLSKVAHDFEDGVEKIRESIKSGTAIQKLKEFIENQGGNKDVVDDYSLFKKSKY
                     KYPVKSTKSGYISKIKAEDVGVSAMILGAGRETKDDILDLSAGIILEKKVGDYVNEGE
                     VLAYMYYNDEQKLSLAKGRFIDSYSIVDSKIEKNKLIYGIVTKEEIKKF"
     gene            71898..72977
                     /gene="mltG"
                     /locus_tag="KRO40_000239"
     CDS             71898..72977
                     /gene="mltG"
                     /locus_tag="KRO40_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HBH2091084.1"
                     /translation="MNFKENRLKIAVLIIVILIILAGIFVFIQIGPYDKNNKKDVIID
                     VPSGASVGKISDILYENKLIKNELLFKLLVKVSNKAPSIKSGTYLLNQSYSNNDIISL
                     LVSGKIYQDGIKVTIPEGATSKEIIAMLVSKNLGDKATFENLIKKPQEFYDKFPYLKE
                     DGITSLEGFLYPETYYFNSKKQSEEDILSEMLKVFDSKYTDKFKKKQKELNMTLQEVM
                     EMASIIEKEAVLDKDRPIIASVFYNRLKVGMPLQSDATIQYIFEERKKIVTYDDLKID
                     SPYNSYKNKGLPPTPISNPGIKSIEAALYPEKTDYLYFVAKIDGGNNYSTNYQDHLKY
                     VKEYKEARDKQSKDTKATNKENTKK"
     gene            73149..73823
                     /locus_tag="KRO40_000240"
     CDS             73149..73823
                     /locus_tag="KRO40_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HBH2091085.1"
                     /translation="MSNIVNDLVEDYIRVTLKEKEGFLKDLEIYAEENSVPIIHKEVS
                     DLLKVLLKVQKPKRILEVGCAIGYSSIFFATIIGKDADIITVERNEKMIEKAKENIKL
                     AGFDNNITILEGDAEEKLSQVQGEFDLIFIDAAKGQYKLFFDLVIDKLKDGGLLVSDN
                     ILYKGMVAHDDFVVRRKKTIVKRMRNYLDYICNCDYLSTSLVPIGDGVALSYKESKRG
                     DVDGIK"
     gene            73810..75057
                     /locus_tag="KRO40_000241"
     CDS             73810..75057
                     /locus_tag="KRO40_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBH2091086.1"
                     /translation="MELNKVELLAPAGDLERLKIAITYGADAVYIGGEIFGMRSAAKN
                     FSKEDMAEGVAFAHERGKKVFVTVNIIPHNEDFLQLEDYLLELEEIGIDAVIIADPGV
                     LSVIKKVIPNMEIHLSTQANTTNYLSANFWYEHGIKRVVVARELSFDEISEIRAKTPL
                     DMDIEAFMHGAMCISYSGRCLISNYMTGRDANKGSCAQSCRWQYHLVEEKRPGEYFPI
                     YEDERGTFFFNSKDLCMIEYIPELIKSGITSLKIEGRMKTAYYVATVVRAYRMAIDEF
                     YRDPENWKFNPMWMEELKKGSHRHFTSGFYLNKPTTEDQNYQSASYVRNYDFIGIVRE
                     TEDEDGLIVVEQRNKMCVGDEIEVMGPYKETMFTKIEEMYNEEGEAIESAPHPRQIVK
                     LKLSVKVGKDYMLRKVIEEKVEE"
     gene            75129..76793
                     /locus_tag="KRO40_000242"
     CDS             75129..76793
                     /locus_tag="KRO40_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2"
                     /protein_id="HBH2091087.1"
                     /translation="MSKKKTPFLKKVGKRSWCIFTIILIIYSVLIYRLVDIQVLKGDK
                     YKQSVESQSVEKVELNSGRGIIYDRNNKKLTDTSKSQVLIVEKEKLNNNYKILELIKK
                     ATKMNDLDIYKAVQEQLTRPIIQIQTKNIDKSMKKELEKNGIMVEEKTMRYAKDGLLS
                     HTIGYIKEDDKSGQSGIEKSMDSVLRNSNEKYISAFKAGDAGNEKSLNILKGSVKTVD
                     NKDKDRHLKTTIDYNIQKKLEQILNKEENPTAAIISEASTGEILAMCSRPNFDQNDIS
                     KSLKGKNGEFENRVIKATYPPGSVFKMVVLFSALENGVIDENYTYNCTGKTKVGNTNE
                     ILRCNKRDGHGFQNLRQAFSNSCNPAFLDIAMKLGKEKILKSAEKLHLFEKVDIGLDE
                     EKIREAPKNISIRNLAIGQENIEFTPLQINQMTQIIANNGTFKPLYLYKSLVDNNMNT
                     IKTYKSSKKEELISPYVCTQVKEYMKSVSRIGTAKDLKDIEGGCGVKTGTAQSSLNKK
                     AIDHGWITGFYPEERPKYVITVLVEGTQKGNKSATPIFKEICESIK"
     gene            complement(76890..77174)
                     /locus_tag="KRO40_000243"
     CDS             complement(76890..77174)
                     /locus_tag="KRO40_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2091088.1"
                     /translation="MCNEISLLDILGTEANYVLDEVELKVQVGKLYEQLNKILTPRER
                     EIVQLRYGLTPYGYKTQREIAQKLDISRSYVSRIEKKALKKLEKELVQES"
     gene            complement(77197..78714)
                     /locus_tag="KRO40_000244"
     CDS             complement(77197..78714)
                     /locus_tag="KRO40_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH2091089.1"
                     /translation="MSVAIYLRKSRADEEAEKQGEFETLSRHKSTLLKLAKEQNLDVI
                     EIKEELVSGESIIHRPKMLELLKEVEENKYDAVLVMDLDRLGRGDMKDQGIILETFKE
                     SKTKIITPRKTYDLTDEFDEEYSEFEAFMARKELKLISRRMQRGRIKSVEEGNFIGTS
                     APFGYDAVTTGRKERILVPNKDADVVRTIFDLYINEDMGCSKISKYLNNLGIKTATGA
                     NWYNSAITNIIKNKVYCGYIQWQKKDYKKSKNPNKIKTVKLRPKDEWIEAKGKHEPLI
                     SEITWKKAQNILKKNGHVSYGNQIKNPLAGIVICKNCGRPLVYRPYADHDYIICYHPG
                     CNKSSRFEFIEAAILKSLEDTVKKYQLKASDIDLDKNNKDSNIEFQKRVLKGLETELK
                     ELGKQKNKLYDLLERGIYDEDTFIERSNNISSRTEEIKDSIKTVKNRLSTVKKDNSKI
                     IEDIKTVLSLYHDSDSLGKNKLLKSVIDKAVYYKSKEQKLDSFELMVHLKLHEDQ"
     gene            complement(78839..79660)
                     /locus_tag="KRO40_000245"
     CDS             complement(78839..79660)
                     /locus_tag="KRO40_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH2091090.1"
                     /translation="MIISKKITAILVSFLIMISMVGCAPKESATEVAKKYLDSIKIKD
                     YEVAYNLLSKDSKESVSLEKFEEYQDTLFKLQTLKDYKLGEENKVEKYKYSNKEYTNL
                     VKIKETDTIKYITENKEDTANFDRYFIIEDNEYKLLWHKDFKRALSSNYVKIARSETE
                     KDEDKDYNKAAIDIKKAIEIDDKNPLAYYTQSYIYIELQRYDEALKSIDKYLEYLDKN
                     NEAYKIDASDAYNLRGVIFMSKSEFNKARESYNKALELNPDNEYAKTNLNDIKGL"
     gene            79851..81278
                     /locus_tag="KRO40_000246"
     CDS             79851..81278
                     /locus_tag="KRO40_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp26"
                     /protein_id="HBH2091091.1"
                     /translation="MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGI
                     IADKQNYTTAILINADSTMSDGLSASGLAGAINAPILLTKKNNIPNATLKRLEKAKKV
                     YIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAF
                     KGEPDAMSVAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTR
                     LGGTDRYDTNKKIINKFYSGVKEFYIASGTDLVYALVGSTAAKNNAIVLVDNDSNKSV
                     LKSTTKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAANAVKKLLGVKKFYYK
                     PNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGN
                     MKVCNPDDYKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAV
                     KINSKNSNGTFGWFFIDIETGKVYN"
     repeat_region   82234..82592
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=82234..82262
                     /rpt_unit_seq="gttttatattaactaagtggtatgtaaag"
     gene            complement(82879..83103)
                     /locus_tag="KRO40_000247"
     CDS             complement(82879..83103)
                     /locus_tag="KRO40_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091092.1"
                     /translation="MDVNQRIKYIRENMNSSQKELLEKTNINTSVMNRIESGERPTRD
                     DGLIIFAKIFGLYTDYILGLSDTEKLNIGN"
     gene            83814..83969
                     /locus_tag="KRO40_000248"
     CDS             83814..83969
                     /locus_tag="KRO40_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="regulator"
                     /protein_id="HBH2091093.1"
                     /translation="MALDVKIEVKIIKDVVILNITHWKKETSLLTVKIARSQGDLSYV
                     KYFANES"
     gene            84215..84466
                     /locus_tag="KRO40_000249"
     CDS             84215..84466
                     /locus_tag="KRO40_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091094.1"
                     /translation="MSSYFITRGDVMKILQQFKPYKYDKEKNIEYDEKIIANQNTEVY
                     IVYPRISDEENRRRWEEFNEVAKEVAINIAMKKVETVES"
     gene            complement(85676..86059)
                     /locus_tag="KRO40_000250"
     CDS             complement(85676..86059)
                     /locus_tag="KRO40_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091095.1"
                     /translation="MRKKFFIGILIVLIISVIAILNIKNDKNVFIGESENWKAKFVTT
                     EGHSKLEIKYKNSKDVVEQKFNYSYQFIDGEDAVVVVKNEILEAGQEKAIKIQRPGLY
                     SNRESSYKLIISWNGNEETINLKKK"
     gene            86186..86530
                     /locus_tag="KRO40_000251"
     CDS             86186..86530
                     /locus_tag="KRO40_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091096.1"
                     /translation="MNYRLKKSVTTILSLLIMTILLPTNASASKVEDSSMKVMYSEKQ
                     VTDMDKLYDMAKNGITDVKSSNEKGIIKNARTGESIYVDSISTTQLLEVKQSKNLTSK
                     IYSKTVFLILIQ"
     gene            86713..86928
                     /locus_tag="KRO40_000252"
     CDS             86713..86928
                     /locus_tag="KRO40_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091097.1"
                     /translation="MHINQTGFISNELGIKQQQKKEPTSNSFSYNAPSSWKPVGRDSV
                     QYNCGFELIATLVRGGSSWAFNFIVQP"
     gene            complement(87913..88230)
                     /locus_tag="KRO40_000253"
     CDS             complement(87913..88230)
                     /locus_tag="KRO40_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091098.1"
                     /translation="MNFRNIYLILMGLGIIILTTIISLIEIKIGFCNEKYFNKLESKY
                     GNIDRKRTIKLEVLYRYVTGFEYIAIGLFTKRLDITIIAIILVATITVILYYLVRKRY
                     ITI"
     gene            complement(88540..88877)
                     /locus_tag="KRO40_000254"
                     /pseudo
     CDS             complement(88540..88877)
                     /locus_tag="KRO40_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889008.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT        35293 a         9434 c        15700 g        28450 t
ORIGIN      
        1 tttttaagtc tattgtagaa tataaacctt gcaatataga gtactatgta ttattatagt
       61 aaatataagt actatacatt atagagtagt aggtgaaaag gcggtggtac ataatgcagt
      121 taaataaaga agtgttaaaa ggttatatcg atatattaat tgtttctata ttagaaaaga
      181 aagattgtta tggatatgaa attgcaaagc aagtaagaga aagaagtgag tttgaattaa
      241 aagaaggaac aatgtatctt gcacttaaaa gaatggaatc taaaaattta attaaatctt
      301 attatagcaa tgaacaaagt tcaggtggaa gaagaaaata ttataattta actaatgaag
      361 gtaaagattt tttagaaata aagaaacaag aatggagatt tattaaaaag gttatgaatc
      421 aatttttggg agaggtggat taatttatga aactaataga tgaatattta gataaactat
      481 ataaaaaatg tgacaataaa agtactatag aattaaaaca ggaaatgaga tgccatctta
      541 tagaatctgc aaatgaattt aaattagaag gattagatga agaagaagca tgtaaaaaag
      601 caattgaaag atttgatgat ggtgatgaaa tgcagtatga attatgtaat ataataaaag
      661 aactatcttt atcattggat aggcataaat caattgtaat ggggtttaaa aaagtattag
      721 gttacataag tataattgca tttttaattt ctggatttat gtggtattac aataatagtt
      781 tacaacataa tatgtataat ttaggaaaag aacttgatgg agaaataaag caattggcag
      841 aaagacatga tatgacaaag attggtgaat ataagttaga acttgaaaaa atacttgata
      901 aagataagta tagtaaagtc aaagctctta gactatatgt aatagatatg aaagatggaa
      961 acactaattt aagttcttct ggattgaatg ctaatatggt atatgagagg gaagcagatt
     1021 ataataacat aagtaatttt atacagcatt taggatataa tggaaaagat tttttagaca
     1081 agaatgggaa tatagtaaat ccagatattt tcttagaata tttcttttat tttgaatcgg
     1141 agatgttaat tccagtagca tttgcatttg gattattatg tataatagcg tattttatat
     1201 taagatttaa aatttcttta ataaaaaata ataattaaat aattcaccaa ataatcttaa
     1261 tttgtagagt aaataagatg tttcaaaata aaatttgaat catcttattt tttattgttt
     1321 gttatactct tttcttttat atttctccat agtggattgt atctatacat aatcacatat
     1381 tttgatataa ttatactttc caaaaaatgt attgaatata caaattataa tctgtataat
     1441 gttgttaggg gagaatgtat gaagtgtata caattttaat tttaaatgta ttattgacaa
     1501 ttctcctcac tctcgccatt accaataatt ggaaaattga catacctgtt acagaccaac
     1561 atttttgaat atattaatta ttatcatttt attgtgatga tatcaaaaat gcaggtttgt
     1621 gagttggatt gtatacgaac tatataggaa atatagaaca gattttccaa gaaatctaaa
     1681 tattctatga ccacgtgaat tgctatgcat acatgttgat aatccatatt ttaaatctaa
     1741 aatgaactta attaatggta gggaattgaa agtaaaatat attataaagg agaatgctaa
     1801 tatgaaaaaa atcaggaaat tagctactaa actattgatt gcaatgatgg ttttaacctc
     1861 atgtatgagt gtaacagttt atggtatgac agctaaagat gttactgcaa agacaccgaa
     1921 aagttatgta gctggaacca acagtatata tggtccaaag ttatcacaag ctcaacttaa
     1981 ttcggtagca caagcaacag cagactttat gaacaagaaa attacaaaga acatgaccac
     2041 agatgctaag attagggttg cttataatca cattaaaaac aacacaacat atgttaactg
     2101 gaacgcagca gagggagcca atactgctta tacattggtt actaaaaaag gtgcttgttc
     2161 tggaatgtgt aggagcttga aagctttatg tgatgctatg ggaattgaat gttattatgt
     2221 acatagtaca acaaatgacc atcagtggaa tcttattcgt tttgaggatg gacgtttgta
     2281 tcatgtagat attgatgcca acaaatcagc aggagcagac atcatataca agagtcttac
     2341 tcacccatta ccatttgaca agaaagcata tccagctgtt ggcgaagtag taaagacaca
     2401 gaatccaacg ccaactgtta agaaacctac gccagctaag ccttctgcgc cagttggacc
     2461 tgggaatcac actatgatag cagatcaaca aggggcaata cttgatgaag tttatggaaa
     2521 taatctacgt ccaaaaattg aaatgtatga gggagttccg tgtagtttaa tcaactcatc
     2581 aataaataca attaagttta caagcaaaaa ttcaaattta gacccatcaa agcatacagt
     2641 tactgtaata gggtttatga atacaccata tggtatggtt gcattagctc cagatggtgt
     2701 acctgatgag tatccttttg aatatgataa gccattttct ttagatttta ctggtaagaa
     2761 cctttctgca gcagaattat caaaaaagtg taaagaaaat aatgtaatta ttaaagtgga
     2821 aattggtgaa acggcatcta attctggaag agggatggta gcatacgcta gatatgtgaa
     2881 ttaatacaaa tatactagtg tacaaataga acatattata aataatgcac cctcgcacaa
     2941 agggtgcatt tatcattata tcagtcattt tagaaaataa aaaaggagtt gaacttaaaa
     3001 ttagattaga aaaattaatt ttgagacaac tccattttaa tttattttta aatataaaat
     3061 catttatttt aaataatatt atgtttgatt aatggctatt taactaattt tgcaaattct
     3121 gcaccaaatg ccatacactc ttttaatgtc tcttcactag ggaagaattt tttcttaaga
     3181 gattctacag gcattttgaa tgacatagat ttaagtaaag tctcagccat agttatacct
     3241 tcaccactcc aaccaaatga accaaatact cctgctatct tgccttggtt agccattggg
     3301 tctataacag agaataaatc ccacataggt ttaaccatag ttttgtttat agttggagaa
     3361 cctagtaata ttacttttga cactactaat gtatcgtgca tttctgttaa tgtcatatct
     3421 tctaaatcat ataattcagc ctttgcacct tctttatcaa gtccttcttt tatcttttta
     3481 gccatctcta aagtattact ataagctgat aagtagaata tagaaacttg attttgatta
     3541 gttgtattaa cagcttctgt agaccactca acatatcttt taacagcagc cattgggtct
     3601 ttagtaagca ttggaccatg agaagtcaat atagtatcaa attctatgtt tagtcctacc
     3661 accttatcta cagcacttaa aacatgttta gcaaatggct taactataca atcatagtag
     3721 tgtttagctg attttagata atcttcacta ttcactacct ctgcatcaac acttgcaaag
     3781 tgacaaccaa atgcatcaca agttaaaaga gtcttgtcct cctcaatgta agtaaacatt
     3841 gtatcaaccc aatgtaagaa tggagcagtt ataaatctaa gatttctttt accgatattt
     3901 aaaatttcac catcttttat tacatgacag ttaaaaggtc tatttatttg accatctaag
     3961 tatagtttag cagctttagt acaataaact tctatattag gatttatatc taataagtat
     4021 tttaaactac ctgcatggtc tggttctgtg tgatgaatta caacatagtc aattttagct
     4081 atatcagtaa cctctgataa attacttaaa aactcatctt taaaatttgc ctttacagtg
     4141 tcaaataaaa ccgttttttc gtccttgatt aaataagagt tgtaagttgt cccaaactca
     4201 gtttccatta ttatgtcgaa tacttttaaa ccttcatcta ctactccagt aaagtagata
     4261 tcttttttta cttcaaaaac tttactcatt tttaaccctc ctaaaattta tcattatata
     4321 agtaacatac cccattttga ggtgaatgaa acaaaagatg tcatgataag tcatgtaaaa
     4381 caatagtttt atgtttataa tatatcatac tttgtaaaaa aattgtattt caataaaaat
     4441 ttaatagaaa atattcttaa atatttttag ctattctatt ttgtgaataa tatgtatttt
     4501 aaattcaata ttttagttat atttttgata gaaaatattt tatcgtgtat aatattactt
     4561 ataaataaga ataaaaataa agagcttgtt tggaggaatt ttaataaatg aataaagtag
     4621 acttgaaaaa aatcttaaaa aaagtagaaa agcctgctag atatcttgga aatgaaataa
     4681 attcaattca taaagatact agtaatagtg aattgataag atatgcacat tgctttccag
     4741 atttatatga agttggtatg agtcacttag ggagtcatat attatatgat gtaataaata
     4801 aggatgaaga tgtattttgt gagagagtgt attctcctgc agttgatatg gaaaatataa
     4861 tgagagaaaa aagtatacca ttatttgcat tagagtcaag agagcctata acaaactttg
     4921 attttgtcac ttttacactt caatatgaac tttcatacac taatatctta aatatattag
     4981 atttagccaa tataccaata ttaaaagaag aaagaacttt ggaagaccca tttataatgg
     5041 ttggtggtcc ttgtgcttat aattccgaac cattagcaga ttttgtagat gtagtaatat
     5101 taggtgaagg tgaagaggtt aatttagaag tagtaaatga gtataaagaa tggaagaaaa
     5161 ataaaacgac tagagaagat tttttatata aaatatctag catagaagga gtatacatac
     5221 caagttttta tgatgtcaag tacaatgaag atggtacagt tcaaagtgta actcctaata
     5281 gagaagggat tactaaaaat cctactaaaa ggataataaa agatgttgag actgtagatt
     5341 atccagaaaa actaatagta ccttatatag atactgttca tgatagaata gtactagaat
     5401 tatttagagg atgtactaga ggatgtagat tctgtcaagc aggtatgata tacagaccaa
     5461 taagagaaaa gagtgttaaa agacttaaag aaatattaga taaattagtt aagaatactg
     5521 gatatgatga aatatcatta tcatcactta gtacgagtga ttatagtaag ttatcagagt
     5581 tgactgatta tttggtagat gaatatgcat ctaataatat tgggatttcg cttccatccc
     5641 ttagattaga taatttttca atggaaattg ctgataaaat acaacaagta agaaaatctg
     5701 gacttacttt tgctccagaa gcaggaactc aaagacttag agatgttata aataaaggtg
     5761 ttacagaaga agatttggaa aatgcaacag aaagagcttt tgagatgggg tggaatagtg
     5821 ttaagttgta ttttatgatt ggtttaccaa ctgagactta tgaagattta gatggtatag
     5881 ctaaattagc ttataaagtt attgatattt atagaaaagt aaatggagga aagctaaaga
     5941 gaagttttag tgttacagtg agtacttcta catttgtacc aaagccattt acacctttcc
     6001 aatggcatgg tcaagatact acagaagaag ttattaataa gcagagacat ttagtaaata
     6061 aattaagaaa taacaatata aaatacaatt atcatgattc aaagactagt ttgatggaag
     6121 cagtagtagc tagaggcgat agaagaatag gaaaagttat atatgatgca tttagactag
     6181 gtgctaaatt tgatggatgg gcagaacatt ttaatttaga tatatggaaa gaagctatgg
     6241 aaaagaataa tctttctata gatttttatg cacatagaaa tagaaactat gaagaggtat
     6301 ttccttggga ccatatagat gtaggtatta gtaaaaaatt cttaattaga gaagacgaaa
     6361 atgctaaaaa agaaaaaatc acttctgatt gtagacataa ctgcaatggt tgtggaataa
     6421 atatacatga tataggaagg gggctttgct aatatgagta agataataag agtaaaattt
     6481 aaaaaggaag gcgacatgat atatatatca catcttgacc ttcagagatt gttacaaaga
     6541 gcgtttagaa gagctgaaat aaacttatca cattctcaag gatttaatcc tcaccctaaa
     6601 atgagttatg gcaatgcttt ggctttaggg acagaaagtc aaggtgagta tgtagatatt
     6661 gaaatagaag aagatgattt atcagtagag gaatttttaa ataaagtatc aattcaactt
     6721 ccagatggga tagattttat caaagcaaaa gaaattgata gacaaacacc ttctctttct
     6781 tctgtgatag actatggaga atatttgttt aatatagatt tgaaaagacc tatgacgaaa
     6841 gagtttgtaa aaagaaaagt aattgacttt atgaataata aagaaataat cataacaaaa
     6901 aagaataaaa aaggtaagat ggttgaagta gatataagac ctatgataag aacctttgat
     6961 gttttaaatt tagaagatga acatattact cttactgcta ctatagctac aggctcaaaa
     7021 actaatttaa atactaatat acttatacca aagatattag agatgtttga acttgatatt
     7081 gacccattag atgttgatat attgagaaga gatttatatg tattagaaga tggggaatta
     7141 gtgactccta tgtaagctcg agaggtgaag ttgtgaaaaa gatagttatt gagtccctaa
     7201 tagggtccca gaaaacagca gtacttgaag atgaaagatt aacagaactt tttgttgaag
     7261 acaatttaaa taagaagact gtatccaata tatatcgtgg aatcgtaaaa aaagttatac
     7321 caggaataga agcttgtttt gtagatattg gatttaagaa acttgcttat ttacaattaa
     7381 aaaagggaag tactataaaa tctggtcagg atattttggt tcagataaat aaagaagaaa
     7441 taggaactaa aggcgcaaaa ttaaacactg agattagtat ttctggaagg tatattgtct
     7501 atataccttc caatgataga actacaatat caaataaaat tactgatgaa aaagaacgat
     7561 ttagattaaa aaaaattact aaggcagtaa ataaggaaaa tctaggatta ataataagga
     7621 ctgaggctca aggttgcact catgatgaaa taaagaaaga tatagaagag ttgaaattaa
     7681 agtatgaaaa cattttaaaa gaatataaac ttggtatagg tccgaaatta ttatataagt
     7741 ctttagattt tgcaactaaa tatgtaaaag ataatgtgaa tgatgatatt gaatctataa
     7801 ttaccaatag ttatgataag tactctgaac ttaagtctat tttaagaggt atagataaga
     7861 cttatgttga taaactgtgt cttgaggaaa atagagatgt atttgattta tacagaatag
     7921 aatctaaaat agaaaaatta ttaaataaaa aagtatggtt aaagagtgga ggttatttaa
     7981 taattgaaaa aacagaagct cttacggtta tagatgtaaa tacgggtaag tttattggaa
     8041 ctggtaaact tgatgaaacc gtttataaaa ctaatcttga agctgcaaaa gaaattgtaa
     8101 gacagcttag aattagagac atagctggga taataataat cgattttatt gatatgcata
     8161 aaaagaagca tcaaaaggag attttacaca tcctagaaga agaatttaat aaagataaaa
     8221 gaaaagctga agtattaggt atgacaaaac ttggtttagt agaagttgct aggcgtagag
     8281 aaaaagaatc cattgataag tattatttaa tgtcttgtcc atgttgtgat ggtgaacaaa
     8341 caataaaatc tgtacattat atactagata gtattgaaaa agaaattatg agaataagtg
     8401 aacatactgt ttacaaaaac ataatggtag aatttaatga ttttattttt gaacaaataa
     8461 aagaatatta tatggatata attgataaaa ttggtgaaaa atataatata aagatttctt
     8521 taaacgcaaa tagtacatta aagcacaata aaaccaatgt tattttcgat aaaatagttg
     8581 acaataaaat gtaaatattt tataattaat aattgtaatg ccgcacagta aaggtttaaa
     8641 tcttcaaatg aagtaccttg tactggcgag tttgaggccg aggaggtgta tttaatgtac
     8701 gctatagtaa agactggtgg aaagcaatat aaagtttctg aaggtgatgt attattcgtt
     8761 gaaaaattag aagctaacgc aggtgatgtt gttactttaa acgaagtatt agcttgctct
     8821 aaagatggag aattaaaatt aggttctcca gtagtagaag gagcatctgt tcaagctaaa
     8881 gttgttgaac aaggtaaagc taagaaagtt atagttttca agtataaagc aaaaaaagat
     8941 tacagaagaa aacaaggaca tcgtcaatca tacactaaga tagttgtaga aaaaataaac
     9001 gcttagttat tggttaagtt atgataaaag ttaaatatta ttataatgat gatttcttgt
     9061 tgcaaggttt ttgtttaaag ggacatgctg attttgctga aataggctat gatatagtat
     9121 gtgctgcagt tacatctaat gctattgcag ttataaattc tttagacaaa ttacaaaaga
     9181 ttgaatttga aaaagtagta ggagaagaag gtcatataga gtgtatagtc aaagatacac
     9241 atgtaaaaga cgcacaatta ttactaaatc actttcaatt agcggttaaa gaaattaaac
     9301 gggaataccc aaaaaatata aaaattttaa aaaagtaggg ggtgactcca tatgttaaac
     9361 atgaatttac aattattagc atctaaaaaa ggggtaggtt cttctaaaaa tggtagagat
     9421 tctatatcta aaagattagg tgttaagaga ttcgatggtc aattagtaac tgctggaagt
     9481 ataatagtta gacaaagagg aactaaaata catccaggaa ctaatgttgg aaaaggtagt
     9541 gatgatactt tatttgcatt agttgatggt actgttaaat tcgaaagaaa agacaagaag
     9601 agaaaaaaag ttagtatata tccagtagct atagctgagt aatatacata aaaggagtgt
     9661 tgaggcactc ctttttctta taatactgat gaatttataa tggtattttt ggtaatgcta
     9721 attaaaagtt tttaattaag taggtgaaga atttgtttat agataaggca agaatatttg
     9781 ttaaggctgg aaatggtgga aatggttcgg tagcatttag aagagaaaaa tacgttccag
     9841 ctggtggtcc agacggtgga gatggtggtc gtggagcaag catcatattt gaagttgatt
     9901 tggggcttag aactctaatg gactttaagt accagaaaaa atatcaagct caaaatggtg
     9961 gcgacggaag caaaggaaaa agagctggta aaaatggaga aaatttagta ttaaaagtac
    10021 cagcaggtac agtaataaga gatgaggcta caggtcttgt attagcagat ttaaaaaaag
    10081 aaggagatac agctatagtt gcaaaaggtg gtataggtgg taaaggtaac caacactttg
    10141 caaatgcagt aagacaagct ccagcttttg caaaatctgg tacagatgga gaagaaagat
    10201 ggataactct tgaacttaaa atgatagcag atgttggtct tttaggattt ccaaatgtag
    10261 gtaaatcaac atttctatca gttgtaacta aagctaaacc caaaattgca aactatcatt
    10321 ttacaacact tacaccaaat ctaggtgttg ttcaaactaa gtttggagat agttttgtac
    10381 ttgcagatat acctggaatt atagagggtg cttctgaagg cataggatta ggtcatgagt
    10441 tcttaagaca tgttgagaga acaaaggtat tgatacatat tgtagatata tctggattag
    10501 agggaagaga ccctattgaa gattttgaca agataaatga tgagcttaaa ttgtacaatg
    10561 aaaagctttc aaagagacca caagttgtag ttgcaaataa atttgatata ttagaagatg
    10621 agagtaagtt tgagaagttt aagagtgaat tagaaggcag aggatataca gtatttaaaa
    10681 tgtcagcagc aactcgtcaa ggcatagatg aagtaatagc ctatgtttct aaaatgctaa
    10741 aagaagtaga agatgtggag ctagtttcag aagaagaaat gtatagacca gaacttgata
    10801 ttggtactga agaagagtta agtatagata ttgaagatgg tgtgtatgta gttacaggta
    10861 aagcacttag aagaataatg tattctgtaa attttgatga tatggaatcc cttcaatatt
    10921 tccaaaaagc tatggagagt caaggtgttt ttgataggct tagagaaatg ggaatagaag
    10981 atggagatgt ggttaaaatt tatgaattag aatttgagtt ttacaattaa tttaaatata
    11041 gattatagat aatttaagta tagaattata gaggtgagaa tatgttaaaa ggaaaacaaa
    11101 gggcgtattt aagatctttg gcaaatactt taaagcctac tacacaaatt ggtaaagaag
    11161 gtgttacaga gagtttctta gagcaattag atggtatgtt aagaactaga gaattagtaa
    11221 aagttactat attagaaaat gcaggtcttg atactaaaga aactgctaat gcagtatgtg
    11281 aagctttaag agctgaattt gtgcaggcta ttggttttaa atttactatt tacaagagga
    11341 atattgaaga gcctaaaata ctttttccag gacatgaaca ggcgaaagca aagactaaaa
    11401 ataataatgt tacaaaaaag ggtaaaccaa ctaaaagagc tgttagataa tagtttatat
    11461 ccttttaggg aaataagtta aaaaaatagt gacaattgga agaaattgta ttatactatt
    11521 aaacataaat ttaaattagc aatcttatca agagtggcag agggactggc cctgtgaagc
    11581 ccggcaacca gtatatttaa ttatacattg gtgctaaatc ctgcagcatt tatgctgaaa
    11641 gatgagtata aacccgtcat atggcttgag tttatactca agcttttttt attggtatat
    11701 ttatatatat aaataattta atataatcaa aatgatgggg gtatgttaca gtgaagatag
    11761 caatattagg gtatggaaca gtaggaagtg gattaattga tttaatagaa aataatactt
    11821 caaaaagaga tatagaagtt gttggaattt tagttaaaaa taaagaaaaa cacaagtata
    11881 agaagtactt tgataagata actactgata tagaagatat atttgacaag gatattgata
    11941 tactagttga agtaattgga ggattaaatc cagcttttga ttatgtaaca agagcgttaa
    12001 ataaaaaaat acatgtagtg acagctaata aagatttact ggctgaaaaa ggtagtgacc
    12061 ttatagaatt agctaactta aataatgtta gcatcaagtt tgaagcatct gtggcaggtg
    12121 gtattccagt tttaaaacca ttgatagaat cactggaagg caacaatata aagagcataa
    12181 acgctatttt aaatgggact tgtaatttta tattatcaaa gatgtatgat gaaaatttac
    12241 cgtatgatgt cgctttaaaa caggcacaag agttgggatt tgcagaagtt aatccagatg
    12301 cagatgtttt aggatatgat agtgctagaa agttatctat attgtctact ttatcttatg
    12361 gaaaaatagt atattggaaa gatttattat tagaaggaat aacttcaata gatgaaaaag
    12421 atatagaata tgcaaaaaaa ttaaattgta agataaaatt ggttgctaga agtaagtatg
    12481 aatcaggaga agtaagtgga tttgttagac cagcattagt ggacaataat aatatgcttt
    12541 caaagataga taatgagttc aacgtagtta ttttagtagg tgattcagta ggtgaacttt
    12601 cttttgtagg taagggagct ggaagaggtg caacaggaag tgctgtttat gcagatatta
    12661 tagatataat agataataga agttcaaata taaagtcttt ttcaaaaggg aaattggatt
    12721 taagtggact tatagaagat gagtgtagtg cagtagttag atttggtggg tataataata
    12781 aagatggaat tttagaatgt ttagataaat atgtagatag ttatgatatt atagatgatg
    12841 aagaattggc gatttttgta agtgcaaagt cagaacatga gattgataga gttttggaaa
    12901 ttgtaaaaag aaataattac agtgaatcag ctaaaaaatt attgaagata gattaatatg
    12961 tttatgcaag aattatgaaa atttaatagg gtgtctcaaa atagagagat aagccttttt
    13021 tccagtgttg aaataataaa aatatatttg attttataaa aaaagagtgt ctcatgaact
    13081 aaaaagttca ttttgagaca ctctttttta atatctggtg aattaataag ataatagaaa
    13141 aatgtatacg ttataattaa ccaataaaga aattttcact agcttcatta atagcttgct
    13201 gagttaccct tatatatcgc tgtgtagtgg ctacagagct gtgatttaaa agttctttaa
    13261 ccaactctaa attattgtta ctcttttcaa attgagtagt agcatagagc tttctaaagc
    13321 tatgtgtact tatattatac agatttaagt atttacaaat tatcctcaac tgtttttgaa
    13381 tagcctttgt ctttatattt actaagtagt catttgattt aagattatac tttcttgcat
    13441 gttcatttat ggactcaatt atatttttat taactggtct atactgtaat ttgcccgtct
    13501 ttttttcatt tatttccaac atattacctt taaaattacc tatctttaat cttaaaatat
    13561 ctgatattct tagacctaaa ttagcttcta acattagtgc caatgcaact ttaggatttt
    13621 ttctaaatct tttttcaacg ccattttcac tataagtaaa gccagtatgt aatagttcca
    13681 ttatcttttt atattcgtct atttctatag gtcttgttgc cattttcaac cactcctctt
    13741 agtttgattt ggtaagttta ggtcggtatt tattatataa tataaatgaa atattatata
    13801 atggaaaaat ttcccagtaa acttatacaa gtgtgatata tgtgattaag gagaattttt
    13861 tgaaaaatat ttctaataaa attattaaat tgtgatgaaa taactatgct gttaaactaa
    13921 ttaaaaaggt tattaaaatt atgacaaata taataaaaaa atggaagtat ttagttaagt
    13981 tttattagtt ttatttttag ttttattttt ttcgtgaaaa tttcttagtg aaaaaagtat
    14041 ttttatatcg cattagtttc ccatttgtag ataaagtttt catatgtttt tttgcaataa
    14101 atacggctga gattagataa attattacta caatttgaag aattgtatca taatagctaa
    14161 gataataaaa ccagattaaa ttattatata taacgttgta tgtatcagca aagctagaaa
    14221 ccaacacagc agagtttgca attggataaa gtataaatat aaagatagca gctaaaactc
    14281 catgcgcaaa tttacttagt atgtataatt ttaaatctat gtccgttttt gatagaaatg
    14341 tacaacattg agctaggatg gataatccac taaatcctat caaaaaacta gctaaagatg
    14401 ctcttaaaat ttctggagaa cttgttatac tagatacttt attgcatcct atagtaattt
    14461 caaatagacc acttacaaat gcttgacaga gttctttact aacacctaaa aatgaaagag
    14521 gcaaatatat aactgatgct attaatgaga ttacattaaa aagagatagt attttaaata
    14581 ctactgaaaa aacaattaca aatccaccaa ctgtaagtaa tgtatttact ccattaaata
    14641 cagcatttcc aaataaaaca aaaaaaccat tcccacttga atttctaatg ttgattacat
    14701 tttttatatt tgtttttaaa tccaattttg tctttggaag attttcatta ccataatttc
    14761 taaagaaaag accaaccaat atagttccta gataatggca gagaatcatt aaataaccta
    14821 agtttgaatt ttggaacata cctgtaccaa ccgaacctat tatgaataaa ggtcctgatg
    14881 tagaacaaaa agacacaagt ctttgtgctt catacttaga aatttgtcca ttactcctaa
    14941 attcagaagc taaacttact cctactggat aaccagatac tgtagatata gcaaaagcta
    15001 aagcgctctt tcctgaaaca ttaaatacaa atctagttat gggattgatg ataaacccta
    15061 taatatccac tatttttaaa tcaacaatta agtttgctcc aattataaat ggtagtagtg
    15121 atggaactaa aacattagac catatagaaa agccttctct tgcagatttt atagcttcat
    15181 ttgggtatag gataatccct aaaactagaa ctccaactat gatagatgga gcaaaaaaag
    15241 caataatttt attttttttc ataatatcac ctgtaaattt gagttataag atattatatt
    15301 aaaagtaata aaaatatatg aatgtaatgg cttaagatat ataatagata tatattacaa
    15361 caacgattat catattggag gaaaaaatgt ttaatagtat agctagtaaa aaagtttatg
    15421 aacaagtaat tgagcaaata caatataaaa tactaaatgg agagttaaaa aagggggata
    15481 aattactatc agaaagagaa ctgtctgaac aaatgaatgt gagtagaact tccataaggg
    15541 aagctattag ggtattagag actatgggag tgatagaaag cagacagggt gaaggaaatt
    15601 ttatatgtac aaatatagaa aaaactttaa tagaaccttt atctatgatt tttaaactta
    15661 ataatggtac acttgaagat atattagagc ttagaataat cctagaaatt gagattgcaa
    15721 aacttgcttc aaagagaata acttcttctg aagttataga attgaaacat ataatagatg
    15781 aaatgagggt agaaactaat aaaaaagata ataatcgagt actggtgtta ttagaccaaa
    15841 aatttcacag taaactagca acattaagta aaaattattt aattcaaagt ctttttatga
    15901 cagcatcaaa attatttgat ggatttatag aagatgcaag agaaaaaata atcgcagaac
    15961 cttttaatga aaatatattg cttaaacagc atgaagctat atacaatgca gttgtagaaa
    16021 atgatgtaga acttgcatgt gagaaagcaa aggaacatat ggattttata agtaaaaatt
    16081 atagaaaaaa tgaaaattaa aagtttgtta taaaataaat tattcttgca aatggtagat
    16141 aatggtacta tcatataaat gtaaaactgg tatgaccaca taccaatttt atagtttatt
    16201 ataatgggag attaaaaatg gtaaagttaa aagtaccgta ttcaaaacaa ggaatgattt
    16261 tagaaatacc tgatgaacgt tttctcggtg ttttggagtc aaaatcggat aattatatag
    16321 aacataagac tcaagaagag atagttgaag aatctatgaa taatcctata ggctctaatt
    16381 ctctggaaga actggttaag gggaaaaaga atgtagtcat aattacaagt gaccatacaa
    16441 gacctgtacc aagtagaata actatgccaa ttatattaag aaggattagg aatgttaatc
    16501 cagaaattga tgtgaagatt atagtggcaa ctggatttca taggccaagt acaagggaag
    16561 agctaattta taaaatggga gaagaaatag tagataatga agatatagtt atgcatatat
    16621 ctactgatga taaatctatg tgtaaagtag ggatattgcc ttcaggtgga gatttatata
    16681 taaacaaact agcatatgag gcagaacttt tgatagcaga aggttttata gaacctcatt
    16741 tctttgcagg tttttcaggt ggcagaaaaa gtgtacttcc aggaatcgca tctgcaaaga
    16801 ctataatgta caatcattgt agtgacttta tagatagtga taattcaaga actggaaaat
    16861 tgaataataa tcctattcat gaggatatgg tatatgcagc taaagttgca aaattagcat
    16921 tcatattgaa tgttgtaata gataaagata aaaaaataat tgcttccttt gctggtgatg
    16981 tcgaaaaagc acatactaaa ggatgtagat ttgtaacaga gttatcaaaa gtaaattcta
    17041 taaaatctga tattgttgta actacaaatg gtggatatcc actagaccaa aatatttatc
    17101 aatctgttaa aggaatgaca gcagctgaag ctacttgtaa agacggtgga gtaataataa
    17161 tgatttcagc atgtaatgat ggtcatggag gtcaatcttt ttatgaaaat gtagcaaatg
    17221 cagattctcc aaaacaactt ttagataaaa ttagaagtgt cgatagagta gatacgattc
    17281 cagaccaatg ggaatttcag atactagcga gaatattatc taaatatact gtgataatgg
    17341 taacagataa gtgtaatcct gaaatgataa aaaaaatgca tatgaaacat gcatttaact
    17401 ttaaagaagc tttagaaatg gcgaatagta tagttggtaa ggagagcaaa gtagtagtta
    17461 tacctgatgg agtatcagtt atagttaaat aaaaaaggag tgtactttat ggaaattttg
    17521 acatgtatta aacaagttcc tggaacgact tcagtagaag ttgatgaaac tacaggagta
    17581 ctaaaaagag atggagtaga ttcaaaaatg aatccctatg acctatatgc tttagaaaca
    17641 gctcttagaa taaaggaaga taagaaagcg aatctaaaag tacttagcat gggtcctcct
    17701 caggcaaaga aggtaattga agaaagtttt atgatgggag ctgatgaagg agcattaata
    17761 agtgatagga gatttggagg agcagatgta ttggctactt cctataccat atcacaaggt
    17821 attaagaaga tgggaaaggt agacctaata atttgtggaa aacaaactac tgatggtgat
    17881 acagcacagg tgggacctga agtagctgaa tttttagata tacctcatgt tactaacgtt
    17941 acaaaattaa ttgaagttaa agatgaaagt atagttgttg aaatagatat gccaaatgat
    18001 ttacaagtat gtgagattga atatccatgt ttaataactg tagaaaaaga catttttcaa
    18061 ccaagactac cttcatttaa attaaaactt aatactaaag atagagaaat acctgtatat
    18121 agcttagatg actttgaaga taaagatgaa aataactatg gacttaatgg ttctcctact
    18181 caagttgtaa gaatatttcc tccaaagcca aatacagata aaaatattgt aagaggaaat
    18241 gcagatgaac taagttttgc acttgtaaat aaattagagg aattaaagtt ggtgtaaggg
    18301 ggagtaataa atgtcaaaga tagttgtaaa tcaagataaa ataactgact taaagagaat
    18361 tttagaaata tgtccttttg gggctataga agaaaagtca ggtatagtag aaataagtgc
    18421 tggctgtaag atgtgcaagt tgtgtgtcaa aagtggacca aaaggcgcat ttgaatttat
    18481 agagagtagt aaagtacaaa ttaataaaga tgaatggagg ggaattgcag tatatgttga
    18541 acatcataat ggaaatatac atcctgtaac gtacgagctt ataggtaaag ctcgtgagat
    18601 ggcatcaaaa ataaaacaac ctgtgtattg tgtatttgta ggaaaagaca taaaagataa
    18661 gtgcagtaat ttgatttctt atggggtgga tgaagtattt gtatatgatg aagatgaatt
    18721 taaagatttt aggatagaac catattcaaa agcaatagaa aactttatag ataaaataaa
    18781 accaacgata gtattagttg gtggaactac attaggtagg tcattagctc caagacttgc
    18841 cgctagattt agaacaggtc ttacagcaga ttgtacaata cttgatattc aatcaaatac
    18901 tgatttagac caaataagac cagcatttgg tggaaatata atggctcata taaacacacc
    18961 taataataga ccacaatttg ccactgtaag atataaaata ttttcagcac cagaaaaaat
    19021 agagaatact acaggaaaga taactttatg taaagtagaa aaaaaagaac taaaatctaa
    19081 aattaaggta ctgagtgtaa aagaaaaaaa taaagaagtt ggtctggaag aagctgaagt
    19141 gatagttgtg gcaagtagag caataaaaaa acaagaagat atggagatga tatataaatt
    19201 agctgataag ttaaacgctc aagtggcagg aacaagacct gtaatagaag caggttggat
    19261 agatgctaaa aaacaaatag gtcttagtgg tagaactgta aaacctaaat tgataataac
    19321 ttgtggtgta tctggagcag ttcaatttgt tgcagggatg cagggtgctg actatatagt
    19381 agcaataaat aaagatgata aagcgcctat acttgatgta gcacatttag ctttaatagg
    19441 tgatatttat gatattattc ctaaattgat tgaaaaaata gaaaataaca aagataataa
    19501 tcaaaaatat atggcatcag cagctaaata gggggataga aatgtataaa ttaatcgata
    19561 aaaaagatat agatttttta atagatactt gtggagaaga aaatgtatta gttggaagtg
    19621 atataaatga agatttttca catgatgaac ttggagggat tgagaagtac cctgaagttt
    19681 tagtaaatgt acttgaaact gaacaagtat ctaaaataat gaaatacgca tataaaaata
    19741 atataccagt cacaccaaga ggtcaaggta ctggtcttgt aggtgctgct gttgccataa
    19801 atggtggaat aatgattaat ctatgtaaaa tgaataaaat acttgaagtt gattatgaaa
    19861 atttaacatt gacagtagaa ccaggtgttt tattgatgac aataggtcaa tatgttcaag
    19921 atagagattt attttaccca cctgacccag gtgaaaaaag tgctacaatt gcaggtaata
    19981 taaacactaa tgcaggtggt atgagagcag taaaatatgg cgttacaagg gattatgtaa
    20041 gaggacttga agttgtacta ccaaatggag aaattataaa tgtaggtgga aaggtggtta
    20101 aaaatagttc tggatatagt ataaaggatt tattagtggg ctcagaaggt actttaggaa
    20161 tagttactaa agctatatta aaattgcttc ctttaccaaa gaaaagtata agtttgctta
    20221 taccatttcc agatttatca atggcaatag aaactgttcc taaaataata aaatcaaaat
    20281 caataccaac ggctatagaa tttatggaaa gagatgtgat attggcagca gaagaatttt
    20341 taggtaaaaa gtttccagat aatacatcag atgcttatct tttgcttaca tttgatggaa
    20401 atagcactga agatatagaa aaagaatatg aaaaagtagc taatttatgt ttagaaaatg
    20461 gtgcattaga tgtatttata tcagatacac aagaaagaaa cgattctata tggtcagcca
    20521 gaggtgcatt tttagaagct ataaaggcat ctacgacaca aatggatgaa tgtgatgtcg
    20581 ttgttccaag agataagata gcagagttta taagatacac tcacgagctt caagacaaat
    20641 taaaaataag aataaaaagt tttggtcatg caggagatgg aaatctacac atatatattt
    20701 taaaagatgg tatggatgat aatacatgga aaataagatt aaaagaaact tttgactata
    20761 tgtataaaaa atctagagaa cttagtggtc aagtttctgg tgaacatggc ataggatatg
    20821 ctaaaaaaga gtacttacat gaatcaaatt cagatgctta tatgatgtta attaaaaata
    20881 taaagttagc ttttgaccct aaaaatattt taaatccagg gaaaatatat tagaaatatt
    20941 aatttaataa tatttataaa acaaaaaata ttaaattaga tttaaatata atattttaaa
    21001 ctttactttt aaatctgaag ctaaattgta aaatttttag gatggcaata tttacttaaa
    21061 tttagaaagt aacataatat ttaagttgat gttgtcatcc taaaagcatg tgtacataaa
    21121 taaagtaaga ctattgtatc ttatataata aagagttaat aaaatgattt ttataaatat
    21181 agttatttta aaaaactact ttacatatat tggatgagta taaaaatcca tagggccttt
    21241 tactaaatct ttattgtttt tataatatat tgaattatat atatttgtag cttttatatc
    21301 ataacttatg agtgttttaa aaatcgtatc atctaatgaa aatgatatat ttgaaaactt
    21361 gtttattatt tttatttcag atttattttt tatctctttt agaatttctc tacctttatc
    21421 attaaaagca agtattctta tataaggtat agtatctatg ttttttataa gttgcacgtc
    21481 gcttttttta atacctaaca atatattgtt tagagttcgt ttgattttgg ttaaagtgta
    21541 tcgcttggat ttaattgcta attgtagttc atgtagaaat tcagatgtaa agatatcttt
    21601 atagattctg ttttctatgc cttcatttac ttcaaaatac tcttttaaag tgtccatatc
    21661 tctaagtata attgttttta aaatatcaaa gaagaagtca tcaaacatag gtaaaaaacc
    21721 attatctatt ttttcattta ggatgttata agttttttct ggaataacat tttttaaatg
    21781 aaaaaggtct gtattttctt taagtgaagt tcttatagca gtagcagaac aaatatcact
    21841 ctcaatttct tcggaattat attctgattg gaccctggag atagtaaatg gttttatact
    21901 actgtttaaa tggatgaggt tttttatgta ttctataccc agtatgttgt ttgatgaatt
    21961 taatgttttt gataattgtt cctttgaata attttgtata aaattatttt ttttgtcttg
    22021 atgtatataa tcaaaaagtg cattagctct agctgttgga aataacagac catcatctaa
    22081 atattttttt aaaagtaact taaattcatt tggttcattt gctaaaattt cagctagatt
    22141 ataaagaatt tctgtatttc cttcttcact accaaaacat atagaattta tgcagtttag
    22201 tgaatttaaa attgttatag caccatgaga aaaaatttca gcactttgac aagcaaataa
    22261 agttggtaat tctataacta agtctacacc attttcgaca gcaatttttg ctctagtgta
    22321 tttatcaaat aaagctggtt cgcctctttg tagaaaattt ccactcatta ttgctacagt
    22381 atgtgttgca tttgtttttt ctatagattt agataaatga tatatgtgtc cattatgaaa
    22441 tgggttatat tcaactatta atccaagtat gttcataaaa tactcctttt atctttaatt
    22501 attttatata tatcacaatt tattataata tgtataaaat ttaaattttt aattataaaa
    22561 ttaaaaaacg taaaaaaatt tataaaaatg tagaaatgtt acctacataa aaaactggtt
    22621 aaatgttatt aaaataactt tattagctct ttatattata ttattataac aaatgggaaa
    22681 gaataatcta cattaagtta acttgttaat atattattag tgaaatacac aatttaccat
    22741 actagaaata tgatataata taaaaaaaaa gtatatactt ttatattaaa aggtgatata
    22801 ttatttatga aaatcgttta atgtatacaa taatatatct ataacaaaat aataaaagat
    22861 agagttttat ttagacattt attacaaatc aaaatttatt acatattatt tataaaaaaa
    22921 tctaaggagg aaataataat gaaaatatta gtattaaact gtgggagttc ttcattaaaa
    22981 tatcaattaa tagatatgaa taatgaagaa gttttatgta taggattggt tgaaagaata
    23041 ggaatagaag gttctatatt aaaacatgaa aaagcaggta gagatgataa atacgttgtt
    23101 gaacaaccaa tgaaggacca caaagatgca atagcattag ttttagaagc tgttgctcat
    23161 ccagaatttg gtgcagttaa agaaatgaaa gaaatagatg cagtaggaca tagggttgta
    23221 catgctggag aaaaatttgc aacttcagta gtaataactc cagaagtaga agaagcttta
    23281 aaagaatgta tagatttagc tccacttcat aatccagcaa acataatggg aatagatgct
    23341 tgtaaagcta tacttccaga tgtaccaatg gtaggtgtat ttgatactgc tttccatcaa
    23401 acaatgccta aatcttcata cttatatggt ttacctcatg agctatatac taaatatggg
    23461 gtaagaagat atggattcca cggaacttct cataattatg tatctcaaag agcagcagag
    23521 atattaggaa aagatataaa agatttaaaa atagtaactt gtcacttagg aaatggtgct
    23581 tctatagctg ctgttgatgg tggaaaatgt gtagatacat ctatgggatt cactccatta
    23641 gaaggattaa taatgggaac tagatgtgga gatatagacc cagctatatt accattctta
    23701 atgagaaaag aaggtttaga tgctgatgga ttggataaat taatgaataa agaatctgga
    23761 gtatatggaa tgactggaat ttctagtgac ttcagagata tagaagatgc agctaaaaat
    23821 ggagacgaaa gagctcaagc tacattagaa gcgtatgtta aaaaagtaca aaaatatata
    23881 ggcgcttatg ctgctgaaat gaatggattg gatgttgtag tatttactgc aggcgttggt
    23941 gaaaatggaa aggctataag agcagatatt gcttctaaca tggagttttt aggaatgaaa
    24001 ttagataaag aagctaatga tgttagagga aaagaaacag taatatctac tgctgattct
    24061 aaagtaaaaa tgcttttaat accaactaat gaagaattaa tgatagctag agatacatta
    24121 agattggtaa aataattaaa ttaaacctat gcctatcaag taaaaatact tgacaaacaa
    24181 atgctagatt tgtataataa atttggtgat atgttgaggt gaacttaatg aaagttagca
    24241 tagaaaaaat aaatagaaaa gaaactgaca aaatagactt gaatttttgt gaaaaaattg
    24301 atactattag ttattgtgat gagatttaca aattagtatc acctgtaaat ttaaaaggga
    24361 aagtgtcaaa gactaataaa ggtttgtatc tagatataga tgtcaatttt acaattgttg
    24421 acaattgttc aagatgtctt aaagaagtag aaataccact agagtattct atacaaggtt
    24481 ttttagtaaa agaagaagat tatgatgaag atgagtttga ggaatttgat ccttttatat
    24541 tcgatggtga agaaatcgac cttattgata taatagaaca gacattagat tttaatgtac
    24601 ctcataaagt tctttgtagt gaaaactgta aaggtctttg tcaagtatgc ggggcaaact
    24661 taaatgaaga agagtgttct tgcagtgaaa ttacaaacga tgaggaatac atagatcctc
    24721 gttttgctaa attaaaagat ttatttaatt aaattttgac taaggaggtg gcgtaaatgg
    24781 cagtaccaaa gcgtaaaacg tctaaatcaa acacaaaaat gagaagagca gctaactcaa
    24841 agatggaagc aacaggattt gtaagttgcc cacaatgtca tgagccaaaa ttaccacata
    24901 gagtgtgtcc agactgtgga tattataaag gtaaagaagt tgtgtctaag taatagcttc
    24961 taaaaagcat gtagagtata ctctacatgt tttttttgta catataaaaa aataagataa
    25021 tttactagag aaaataagtg gattttatgc atattaaaaa atagaaaaat aataatataa
    25081 gtattgaaaa tttttgtgtg ttactatata ctactattag tagctggtac taattacagc
    25141 tataaaattt ggagggaaca tgaaaaagaa aagtaaagcc caaagacaaa aagagcttat
    25201 agatatgcta aagacagatc ctttttatac tgatgaagaa ttatcaagtc tgtttgatgt
    25261 aagtatacag accataagat tagatagaat gagtctaaac ataccagagc taagagaaag
    25321 agtcaaatca atagcagaaa ctcagagttc aaaagtaaag actttaggag taaaggaaat
    25381 tacaggagaa atcattgatt tatctgtagg gcgattaggt atatctatgt tagaagttac
    25441 acaggacatg atttactcta agactaatac tttaaaagat acgtatattt tttctctagc
    25501 agattcattg gcaatggcta taatagatgc acctaaggtt attatgagag ttgcaaatgt
    25561 aaaaagtttt aagttgatag aacaacaaga taggcttata gcaaaagcag aagtgtatag
    25621 aaatatagat aaaaagcatt atgtaaaagt tgttatcaac aataaagccc aagagcaaat
    25681 atttagagga aagtttatct ttgaagaatt agattaggag ggaaattatg aaaatagtaa
    25741 ttgatggaat gggtggagat aatgcaccta aatctaatgt agaaggcgca gtaaatgcta
    25801 taaaagaata tcaggttgat ttaataatca caggagataa agatttactt gaaaaggaat
    25861 tttcaaatta tgaatttgat agaaataaat tagagatagt tcatactact gagattatag
    25921 aaaacgaaga taaaccagta aaggctataa gaagtaaaaa agattcatct atggtagtag
    25981 cattaaatct tgtaaaagaa ggaaaggcag atgctataat atcagctgga aatacaggag
    26041 ccttacttgc tggtggatta tttgttgttg gtagaataaa aggaatcgat agaccttgct
    26101 tatgttcagc aataccaaat gtaaagcgag gaatgacact tatagcagac tgtggcgcaa
    26161 atgcagattg taaacctaag aatctagttg aatttgcagc tatgagtaat atttattcaa
    26221 gaaaagtttt aggtcttgaa aatcctaagg tagcattagc aaatgttgga ctagaagaag
    26281 gcaaaggcaa tgatttagtc aaaaggtcat atgaagaaat taaaaaatta gatttaaatt
    26341 ttatagggaa tgtagaagct agagaagtta taaatgcata cacagatata atcatatgtg
    26401 atggatttac aggtaatata ttacttaaat ctgctgaagg tgtagcactt tcagttatga
    26461 gtcttataaa ggaaactttt atggccagta caaaaagtaa aataggagca ttacttataa
    26521 aggatgattt aagaaaatta aaaagtttta tagattattc tgagtatggg ggagctccac
    26581 ttttaggtct aaatggagga gttataaaag ctcatggtag ttctgatgct aaagctataa
    26641 aaaatgctat aaatcaagga ataaaatttt caaagggaaa agtcgttgaa gatattaacc
    26701 aatttataag caaatacaat gaagaaaata aaaataacga agatgaataa actcgttttg
    26761 gaggtttaat atataatgaa tacaaaggct ggaatattag gagtaggaag ttatctacct
    26821 gagcaatcat atgataattt tcacttcgaa aaaataatgg atacatcaga tgagtggata
    26881 agtactagaa ctggtattaa ggaaagaaga tttgccaaag agtctgaagc aacttctgac
    26941 ttagcatcta aagctgcctt aaaagctata gaatgtgcaa agttaaacgt agaggatata
    27001 gagctgatta tattagctac aattactcct gatatgtctt tgccttcaac tgcatgtata
    27061 gtacaagatg caataggagc agtgaatgct actgcatttg atatatcagc agcttgttct
    27121 ggatttgtat atggagtaac tattgcaaag caatttgtgg aaacaggttg ctataaaaat
    27181 gtgcttgtaa taggagcaga aacttgttct aagtttttaa attatgatga tagaacaaca
    27241 gcagtattgt ttggagatgg agctggagca gctgttattg gccctgtaaa tgagggtgga
    27301 atactgtcta cacatatggg ctctgatggt aaaggaaaag attgtttaaa agtacctgct
    27361 ggaggttcaa gacttaaggc aagtaaagag actgtagaag ctaatctaca tacaatagaa
    27421 atggcaggta gtgatgtgtt taaatttgca gttagaaaga tggcagaaac ttctttaaga
    27481 gctcttgaaa aagcaaatct aaatacaact gatatagact acttagtgcc acatcaagct
    27541 aatataagaa tcatacaagc ttcttctaag agattagagc ttgatatgaa aaaagtttat
    27601 gtaaatatag acaaatatgg aaatatgtct gctgcatcta taccagtagc attagatgaa
    27661 gcttatagag aaggtaaaat taaaaagggt gataatgtag ttttagttgg ctttggtgga
    27721 ggtctaactt ggggggcttc agttgtcaag tggactttat agtataaaat atctaaaatg
    27781 atttaattaa caaaattaaa cttatacaca aaataaagtt gattaataat aaaaagttta
    27841 cttttatgat ttcaagtgaa ggagaattgt atgaataaaa tttgcaaaat attaaatata
    27901 aaatacccag ttatccaagg gggaatggca tgggtagcta ctgcatcatt agcaagtgct
    27961 gtatctaatg caggaggact tggcataata gcagcaggaa acgcaccaaa agaagctata
    28021 aagaaagaaa ttgttgagtg taaaaaatta acagataaac cttttggagt aaatgtaatg
    28081 cttatgtcgc catttgttga tgatataatt gatttgatta tagaagaaaa agttcaagtt
    28141 attactactg gtgctggaaa tcctgcaaag tatatggata gattaaagga agctggaaca
    28201 aaggttattc ctgtagtacc tacaatagct ttggcacaaa gaatggaaaa gctaggagct
    28261 acagcagtaa tagcagaagg tactgaaggt ggaggacata taggagaact tactactatg
    28321 gtcttagttc cacaagttgc tgatgctgta aacatacctg taatagctgc tggaggaatt
    28381 gtagatggta gaggaattgc agcatcattt gcattaggtg ccagtgcagt tcaagtagga
    28441 actagattta tttgtagtga agagtgttct gtccattcaa actataaaaa cttagtacta
    28501 aaagcaaaag atagagatgc aattgtaaca ggaagaagta ctggtcatcc agtaagaaca
    28561 ttaaaaaata aactatcaaa agaattttta aagatggaac aaaatggagc tactcctgaa
    28621 gaactggata aaaaaggtac aggagcttta agatttgcaa cagtagatgg agacatagaa
    28681 aaaggttcat ttatggcagg tcaaagtgct gctatggtaa aagaaataac accttgtaag
    28741 gaaattatag aggctatggt aaatcaagca agagagatta tgccagcaat agaactgtaa
    28801 atcaggagga gcaagatggg aaaagttgca ctagtattcc ctggtcaagg agctcaatat
    28861 gtaggtatgg ccaaggattt atatgaaaat aatactgttg ctaaaagtgt aatagatgag
    28921 gctagtgatg ccttaaatat ggatttaaaa aaccttatgt ttaatggaaa tgaagaagaa
    28981 ctttctaaaa ctgaaaacac tcaacctgct atggttacac atagtgtagc agtattaaaa
    29041 gcggtacaag ctcaaataga tttaaaatat aatgcatgct taggattatc cttaggagag
    29101 tatagtgcgt tggttgcagc agatgcaatt gactttaaag atgctgtatg tttagttaaa
    29161 aaaagaggta agtttatgca ggaaacagtt ccagcaggtg ttggagctat ggcagcaatt
    29221 ttaggtttag atagaaatgt acttgaaaat gtggttaaag atatacaagg aggtattgta
    29281 gaagtagcaa attacaattc tcctggacaa atagttatat ctggtgaaaa tgaaaagata
    29341 gaagaagcaa tggtaaaatg caaagaagca ggagcaaaaa gggcagttaa attaaatgta
    29401 agtggacctt ttcactcatc aatgttaaaa gaagctggtg taaaattggc cagtgaatta
    29461 gaaaaagtta acataactaa acctaaagtt gatgtggtgg caaatgtaaa tgcagattac
    29521 tataaaaacg aaggtaaaga cctgcttata aaacaagtaa gttcatctgt tctttgggaa
    29581 gattctatag aaagactttt aaatgatgga tatgatactt ttatagaaat gggacctgga
    29641 aaaactttaa aagcatttat taagaagata gcttccaata aaaaagcaaa tgtcaatatt
    29701 tataatatag atggtataga ttctcttaat gaatttgtac aaaattatag aaatggagag
    29761 atataatgat aaatcttaca ggacaagtag cagttgttac tggtggctct aggggtatag
    29821 gaaaagaaat agcaaaaaaa ctagcatctt ttggagctga tgtagtaatc aattatactt
    29881 ctaaagaaga tgaagcacta aaaactaaaa atgaaataga aagtatgggg gtaaagtgta
    29941 cctctataaa atgtgatgta tctaaatttg atgaagtgaa tcaaatgata gattctgttg
    30001 taagcgaatt tggaaaaatt gatatattgg ttaataatgc aggcataact aaagatggtc
    30061 tgcttatgag aatgaaagaa gaagattttg atagagttat agatataaac ttaaaaggtg
    30121 tctttaattg tacaaaagca gttactaaac ctatgatgaa aaagaagtat ggaagaataa
    30181 taaatatgac ttcagtagtt ggaattatgg gtaatgcagg gcaaactaat tattgtgcat
    30241 caaaagcagg tgtaattgga tttacaaaag cttctgcaag agagttagca tcaagaaaca
    30301 taaatataaa tgcagtagca cctggattta tagaaacaga tatgactaaa gtactaagtg
    30361 atgatgtaaa agaatcaaca ctagcaaaca taccaaagaa atcttatggt aaaccagaag
    30421 atgtagccaa tgccgtagca tttttagtta gtgacatgtc aagttatata acaggacaag
    30481 taataaatgt agatggtgga atggtaatgc aataataatt taaaaagtag agaaatctat
    30541 taaaataaaa aattttagga ggtacacaat gtttaataaa gttgtagaaa taataataga
    30601 gcaattagga gtagaagata aagaaataac tatggaaaca tcattaatga aggatttaga
    30661 agcagattca ttagatgcag tagaaataat aatggcactt gaagatgaat ttggtataga
    30721 aataccagat acagaagcag aaaacttcaa atctatagga gatatagtta agtatataga
    30781 agctaataaa tagtcgagct ttaaaaaagt ggaggtatcc gatgaataaa agagtagtaa
    30841 taacaggact tggatgtgtt acgccgttgg gaacaggaaa agaagagttc tggagtaata
    30901 taaaatctgg agtatctggt atagataaaa taactaattt tgatgctagc acatatcaaa
    30961 ctcagatagc aggagaagtt aagaattttc atccagaaga atatataagt aaaaaagaat
    31021 tgaagagatt agataaattt gctcaatttg caatagtatc tgctaaatta gcagttgaag
    31081 atgcaaatct tgatttagat aaagttgata gagaacgttt tggtgttata ataggttctg
    31141 gaataggtgg agttgaagct atagaaactc aacataaaat tcttttggaa aaaggaaata
    31201 aaagagtaag ttcacttttt gtacctatga tgataggaaa tatggcagct ggtcaagttt
    31261 caatattttt aggagcaaaa gggcctaaca ctaatgtatg tacagcttgt gcatcaggaa
    31321 ctcattcaat aggtgatgct tttaaggtaa ttcaaagagg tgatgcagac atcatggtag
    31381 cagggggctc tgaagctgct gtaacaggtc ttgcttttgc tggattctgt aacatgaagg
    31441 ctatgtcaac tagaaatgat gaccctaaaa ctgcatcaag accatttgat aaagacagag
    31501 atggttttgt aatgggagaa ggagcaggta ttgttatctt agaagactta gaacatgctt
    31561 tagcaagagg cgctaaaata tatgcagaag tagttggata tggtttaact gctgatgcat
    31621 accatatgac aactccagct gaaaatggag agggagcagc taggtctatg aatatggctt
    31681 tgaaagatgg aaatgttcca ttagaagaag tagattatat aaatgctcat ggaacttcaa
    31741 cttattacaa tgatttatat gaaactatgg ctataaaaac tgtatttgga gaaaaggcat
    31801 atgacttatg tgtgtcatca acaaaatcta tgactggtca cttattagga gcatcaggtg
    31861 ctatagaggc tgttgtttgt gctatgagta tagaagatag ttttgtgcct ccaactataa
    31921 acatacaaga agttggtgaa gatttggatt tagattatgt tccaaatcaa ggtaaagaaa
    31981 aaaatattag atatgcacta tcaaattctt taggatttgg tgggcataat gctacaatag
    32041 tactaaaaaa atatgtataa ataaatatta aatataaaac taaaaaacaa gcacttgttt
    32101 taactgtata aatttatatt agcttaaatt taaagtctcc taaattattt taggagactt
    32161 ttttattaag atttaagtct agcatatgtt gtaaatcatt ttgatatatt gtattattaa
    32221 ttattaagag gttatttata tatgcaagtt ttcattctac aatatacaaa aggaggacta
    32281 aaattttgaa ttttagacta ccaaagaaaa ggttacccaa aaagataatt tttatatgta
    32341 taatacttat tagtattatt ttgtttataa agtatgacca aaatggattg aaagaaagag
    32401 aaattataaa taagggaaaa tatatgtctg aaagccttgt ggcagataag gagtatgatg
    32461 aagcaaaaaa agtggttaag acttctttcg aatctattcc agaaaaaaaa tacaataaag
    32521 tatataatga agtttgggat atgttaaaga ctatttcata tgttccagat ggaacgaaga
    32581 tagtcattga ttctttagaa aagatgagag aatcagatgt gaaattatct gatgaatgta
    32641 gatttaatat agaaaaaaga ttagcatcag tgtatataat ggataataat tattctaaag
    32701 cagtagattt aactgtaaag tctataaagt tggctgagaa attggggaat aattatgaaa
    32761 aagcaagact agatgttgat ttggcgagca tatttttaaa aataggtagc tatgaaacag
    32821 gagagaaatt aataaaggat tcttttaaaa tagatattga tgaaggtgaa aaaaatggaa
    32881 tggttagatt atatgctatt ataaatctag cagaaatata tgtagaagag ggagaatatg
    32941 ataaagctat tgaaataagt agcaggataa aagattataa aaagtttgta aatacggata
    33001 attacaatga ttttgatata atggcctcta taatgcagtc aaatgcgtat gtgggcaaaa
    33061 ataatataca aaaggcaaag acttttttag aaaaagctga ttatcttata aaatcagata
    33121 gaacagttta tatattagat aaagatatgt actattatat ggcaatggga aacttagaat
    33181 ataaaagcga aaattataat tctgcaatag ataattataa aaaaagttta gagatatcta
    33241 ctaaaagaaa gttaacccag gagaaaataa aaaatttaaa taagatatta aatatatatg
    33301 aaaaacaagg aaatatagaa tctttaaatg agtatcaaaa gatgttaata aatgaatata
    33361 aagagaacaa aagtataaga gattcagaga ctagtttcta tataattgat aaagtatcaa
    33421 acgaaagtaa gctatttgaa aaaactaaaa aagaaataaa atattataaa atattattta
    33481 cagtaatttt aattgctata ttagggtcta cttttttata caaccgattg aagtatttta
    33541 aagcacaaaa tttacatgat ggtcttacaa atgtttataa tagaaaaagt tttgatatta
    33601 tgtatgaaaa gtacagagag aaagatgata attttgcact tgtgatgata gatattgata
    33661 atttcaagct cataaatgat aattatggac ataaatttgg tgacactgtt ataaagggaa
    33721 taacaaatac catttgtgtt atgttagaac aagatgataa agtctttagg tacggaggag
    33781 aagaattttc tgtattaata agaaataaat ctggtgagga agtagcagat ataattgaca
    33841 gtataagggt tgcaattgca aataaaaaat ggaatgatga tgtgactgtg actataagtg
    33901 caggtgtagc tcatatttca gatagcaaag atgtactaga agaagctgat aaaaatttat
    33961 ataaagcaaa acaacttggt agaaataaag tagtatataa gtaattatat actatataaa
    34021 taagaggtat aaatatgaaa caatcaatag ctatagtaac tgataaaata actaaactat
    34081 catctttctt agaagaaaat atacgtttgg ttttaggtaa ttatattgat ataaaccact
    34141 attatctgga agttttaaaa gagaatgata aaatacaagg tgattttgta ctagtaatga
    34201 atgatgatag attaaacagt atgagaaagc atttagtaca agatagtaag attatagtga
    34261 taaggagaac acttaaagaa aatgaaatat atggattatt ttcaatacca aatggaactg
    34321 aagtattggt tgtaaatgat acaaaagaaa ctaccttaga aacgataagc ttattttaca
    34381 aaataggagt aaaaaattta aagtttactc catatattga aggaaaaatt tataaaaata
    34441 tagacatagc tataacgcct ggagtaaagg gaaaagtacc aagttatata aataaagtaa
    34501 tcgaccttgg aaatagatat attgatatat ctacctttat agaaataata aatggtctta
    34561 gaatagatgt taaagaaata cgtaaaaatt taatggcata ttctgagagt ttaataagtt
    34621 tagataatgg agttaaagat aattataggc aactgttttt aaaaatagaa gaacaagatg
    34681 ttatattgaa tctatcaaaa gatggaataa tatttacttc agcagatggt ataataaaca
    34741 catttaataa agaagcttta aaaattttag gtataaatga aaatccacaa ggcaaaaaca
    34801 tagaagatat catttctgaa gatttaaata ttttacttga agacaaagaa ataattgatg
    34861 aagtggtatt tacaaataaa aaatatataa atgtaaataa aaaaagtatt ttttctatgg
    34921 ggaataaagc tgggatatat tataacttac aagaaataac gtatataaaa aaattagaac
    34981 aaaatcttac taataaatta agagaacaag gtcagatagc aagatataca tttaaagata
    35041 taaaaactaa aaataaaaat atggtaaagt gtgtagaatt ggctaaaaaa atatctaaat
    35101 cagacctttc tgtattaata ataggagaaa gtggtactgg taaagaatta ttatcacaat
    35161 caattcataa tgcttccaat agaagtaatc aaccgtttat agcagttaat tgtgcagcag
    35221 ttccagatag tctattagaa agtcaactgt ttggatatga aaaaggctct tttacaggag
    35281 ctttaagaga aggaaaaaag ggtctatttg aacttgctaa taatggaact atatttctgg
    35341 atgaaattgg agatatgcct ccattgctac agacaaagtt actaagggta ttacaagaaa
    35401 agcaggttat gcctataggt tcccataatg ttataaacat agatgttagg gtcatagcag
    35461 caacaaacaa aaacttacta aagatgatta gagaaggaaa atttagagag gacctgtatt
    35521 atagactaaa tgtattgcca atagatgtac catcattgag gaatagaaaa gaagatataa
    35581 taacacttat gaatttcttt ttgaaaaaca atataagact ttcgccagaa gttataacta
    35641 ttttagaaaa atataattgg ccaggaaata taagagagtt acaaaatgtt gcttcttatg
    35701 taagtctaat gtgtgatagt atggttttta gagatgactt accaccatat ataagggtag
    35761 aatgtgctaa caattatgaa gatggatttg gttatacaag aaaagaattt gaggaaatac
    35821 tgaggattct atatgaaaga agagagtcat cctctggaat tggaagaggg tttataatcg
    35881 aaaagcttat acaggaaggt attgagattt ctgaaagcaa agttagaaag gtgctatctt
    35941 atttaagtga atgtggatac atatcatcta aatctggtag aggaggaagt caaataacct
    36001 cagaggggat aaaactttat aataatataa attaagctaa gtatttgata ttgaaatcac
    36061 atattttgaa tttagatatt taaataataa taaactttta tatttataga gattaattta
    36121 tattatgtca gaaagaatat tgtaatttat aattaaatat taataggttt ttaaaatagg
    36181 attagatagg taataggtta agttagaata acccattacc tatttttatt tgtaagaaaa
    36241 gtgtacatag aattagaagt aaaaaataca actaataaaa ctattgaaaa tactagataa
    36301 ataataaata aaaataatta tagattttgg catacatatt gctaattata gagataagac
    36361 gacaaaataa ttgggaggtt taatgatgaa atacaaaaca acagggactt gtgctacaga
    36421 aattgaattt gaagtaaaag aaaataaagt tacaaatgta aactttatag gtggatgtga
    36481 tggaaattta aaagggctaa aagtattagt tgaaggcatg aatatagaag atgtaataca
    36541 aaagttaaaa ggaatagagt gtaaaacaaa gccaacatct tgcccagacc aactgtctct
    36601 agcattggaa aattatatga atataaagta atacataaaa caatcgatta gttaggagtt
    36661 taattatgaa accaataata gggattttag gaaatttaat aataatggaa aatggtatgt
    36721 ttccaggtct tgaaaggtca tatgtaaata atgattatat aaatgcagtg ctaaaaggtg
    36781 gcggtagtcc agtaataatt cctgtaaata cagataaaga agttataaaa aaacagattg
    36841 aaatggttga tggagtctta atatctgggg gatgggatat caatcctcaa ctgtatggag
    36901 aagaaacaag agaagaaacg acatttatat atccagaagt ggatgaattt gatttaattg
    36961 caataagtat agcattagaa cttaaaaagc ctatattagg tgtatgtagg ggactacaaa
    37021 ttttaaatgt aagtttagga ggaactttat atcaagataa taatcttata gaaggaagtt
    37081 atataaaaca tacacaatct tctaaaagac atgtagctac tcataaagtt gatgttaaag
    37141 aaggaagtat tttagaggga attttaggaa aacaattact tacaaatagt tatcatcatc
    37201 aaagtgtcaa tcagcttgga aaaggattaa aagccatagc atactcaaaa gatggtataa
    37261 tagaagctat tgagaaagag gatgaaaatt ttgtagtagg agtacagtgg catccagaaa
    37321 tgatggtaga ttactgtgat aaaatggaaa aactatttaa atattttata aatatttgtt
    37381 cgaatttata atataccttg gggggattga acatgaacga aaagaacaaa atgggattaa
    37441 taagtattat acttttaggt attaatgcag tagtaggagc tggagttttt ctattaccag
    37501 gagatgcaat gaaatcattt ggtgtagcaa gtatatttgt atatatattt gatatgttgt
    37561 tagttttatc tatggcattc tgttttgctg aggttgcagg taaattcaat aaaaatggtg
    37621 ctgcctatgt atatacaaaa gaagcttttg gagatttttg tggttttgaa gtaggtctta
    37681 tgaaatgggt aataggatgt atttcttggg gagctttaat agtaggtttt cctacatcat
    37741 tatcagcagt atgggctcca gcaggtgaac cacatataca aaaaattata attgtagcta
    37801 tgatagttgg gcttacaatt ataaacttat taggtgtatc tctatcaaaa attgtacaaa
    37861 atgttataac tgtaggtaaa ctaattccat taatactatt tataggaata ggtatatttt
    37921 ttataaaagg agttaatttt acttcttcaa caatggtacc tccaggagct ggagcaacag
    37981 agtttggagc agcagcactt ttaatgtttt attcatttac aggatttgaa tctatagcag
    38041 ttgcagcaga agatatggaa aatccacaaa aaaatatacc aatagcaatt ataagtgtaa
    38101 tagtaattgc atcaataata tatatattaa atcaagttgt atgtgttggt atactaggag
    38161 attcgttatc tagtacatct acaccagtgg cagatgctgc aagaatatgc tttggaaata
    38221 tgggagctgg attggttacc tttggaacat tggtttctgt tggtggaatt tgtatgtgtg
    38281 gtgcttttgt aaatccaaga agttgtgtag ctttagctga tgataaaatg ttaccgagaa
    38341 tatttgcaag aaaagataaa aaaggtacac catatgtagc gataatagct actatgttaa
    38401 tcactatacc aatagctcta tctggaagtt ttgctgaatt agcagcaata agtgcagttg
    38461 ctagattcat acaatacata ccaacatctt tatccgtatt agtgtttaga aagaaaagac
    38521 cagaattagt aggtactttt aaaactcctt ttggagcagt gattcctcta attgctgtat
    38581 gtgttggaac atggttgtta ttccaagcat ctatgcatca attaattatg ggattaggag
    38641 ctttggcaat tggagtacca ttatacttta taatgaagtc ttataataga aaaatctatg
    38701 gtgaaaattt aaagaaaata gtttaattat gttataacaa tttattgagt taaaattaga
    38761 cattggcaga aaattaaata caaataagta tctacaaggc tatattaaaa tattattaat
    38821 tttttatttt aatatagcct tatattgtta tcaataaatg aaaaatattg taacaacaga
    38881 agaacaatag tattatgttt atagacaaaa aacttattag gaggtaaatt tatgccaaca
    38941 ataacattaa aaaatggtgt agacgtactt attagagaag gtgtaagaga agatgctcaa
    39001 agcattatag atttttataa tgaagtgggt ggagaaactc attttctgtc atttggaaag
    39061 gatgaatata aaatatcttt ggaggaacaa gaaaatgcta tagaatcagc aaaagcatct
    39121 gataattctg ttaaactgat tgcatttata gatggtgaaa tagttgggat tgcaacgatt
    39181 gattctaatc aaaaagcaaa aggaaagcat gttggagtat taggaattgt tgtaaaagaa
    39241 aaatattggg gaattggatt gggtaaaagg cttatgttag accttataga atggtgtaaa
    39301 tcaaatggaa taaccaagaa gataactctt gtcactaatg aagaaaatta taatgctata
    39361 ggattataca aaaaagttgg atttgaagta gaaagcatac taaagaaaga atgttattat
    39421 aatggtgttt atactgattt aataggaatg tcacttttat tgggaatata attagtgtac
    39481 attttatctc gaaaaaagta tattaagtat ggtataatta aaaaagaata taacttaata
    39541 taattttgga ggacgaatta tgaaaaatct gtgtaaaata tcagatgatt atttaaacag
    39601 caagcttaag tatttaaagt tattatcaaa acaatatcca agtatatcaa aagcaagtac
    39661 agaaataata aatttagagg ctatattaaa tcttccaaag ggaacagagc attttataac
    39721 agatgtacat ggtgaatatg aaccatttgt acatgtatta aaaaatggtt ctggtgtaat
    39781 aaagagaaaa atagaagaat tgttttcaaa tacaataaga gacagcgaaa aaaaaatgtt
    39841 agcaactctt gtatattatc ctgaacaaaa gttagaccta ataattaagc aagaggaaaa
    39901 tatagatgat ttttatagaa taaatattta tagacttata gaactttgta aatatgcttc
    39961 tagcaaatat actaggtcta aagttagaaa actgttacca gaaaatttta aatacataat
    40021 agaagaactt ttgcatgagc atgttaaaag tgaacataaa gaagagtatt ataaaagtat
    40081 agttgaaaca atagttgaca taggaatagc taaggagttt ataattgcta tttctacagt
    40141 tatacaaaaa ttggttgtag atagacttca tgtaatagga gatatttatg atagaggtcc
    40201 aagaccagat ataattgtcg ataagcttat tgaacatcat tgtgtagata ttcaatgggg
    40261 aaatcatgat atattgtgga tgggtgcagc ctcaggtgaa aaaacttgta tagcaaatgc
    40321 actgaggata tcagctagat atgcgaattt agacattgta gaagacatat atggaataaa
    40381 tctattgcct ttagccactt ttgctataga aatgtataaa gatgaccctt gtaaagaatt
    40441 tattccaaag gttaatgacc aaagtgtaac aacaacagaa aagtctttaa tggcaaaaat
    40501 gcacaaagca ataagtataa ttcaatttaa gcttgaaggt gaggttatca gacgaagacc
    40561 tgaatttgaa atggaacata gactcttgct taatatgata aactatgatg aaggtacgat
    40621 taatttaaaa ggtaaaacat ataaattaaa agatacttat ttacctacaa tagacaaaaa
    40681 agacccatat aaattaacta tggaagaaag aaatgttatt gataaattag tatcttcatt
    40741 tagaggtagt gaaaaactac aaaaacatgt ttcatttttg ttttctaaag gaagtatata
    40801 tttaaaggct aactcaaatt tactgattca tggatgtgta ccgttaaatg aagatggaag
    40861 ctttatgtct atgaatataa tgggaaaaga gtataaaggt aaggctctta tggataagat
    40921 ggagtctcta gcaagagaag gatttttctt taaagataag gcagaagaaa aactgtatgg
    40981 catggatatt atgtggtatt tatggactgg gaaatgttca tcattatttg gtaaagatga
    41041 tatgactaca tttgaaagat actttatagc tgaaaaagag actcataaag aaaataagaa
    41101 cccatatttt aaacttagag aaaatgagat ggcttgtaaa agattatttg aagaatttga
    41161 tttagaactt gatgaatctc atataataaa tggtcatgtt cctgtggaga gtaaaaatgg
    41221 agagagccca ataaaagcta atggtaaaat tctcgttata gatggtggtt tttctagggc
    41281 ttaccaaaaa actactggta tagctggata cactttgata tacaattcta gaactttgca
    41341 attagtatcg catgaaccat ttaattctgc tgaagaagcc attgcaaatg aaagtgatat
    41401 cttatcgaca actgttgtag tagagcataa ggcaaagaga aaaatggtga gagatactga
    41461 tgaaggaata aagatacaag aggaaataga agatttaaaa ctacttttaa tggcttataa
    41521 gaaagggcta ataaaagaaa tgtagatgtt atagaggcac ttcatgattg aagtgtcttt
    41581 ttgttaatac ttattaaata tattataaag attaataata gtagtttata ttatacttac
    41641 taagtgaatc caagataaat gggttcactt tttttattta taaacattat taaaaaaata
    41701 tagatgtttt ggttatattc cttgtccttt ataaatagaa ttatataaac aaaggaggag
    41761 gacaagagat gaataaactt tctgatgaaa taataaactc tctttctaca actataagag
    41821 aaaaggtaga aaaagtctca aacaataatc tgaacataga agaaattagg ttacgctcac
    41881 aaaaaccatt gatactaaat gcaaactcta aagattattt ttacaatcaa aaaactatga
    41941 cacttgattt aaatcaacaa aactcatatg tagtaacaag agaagatgta gagcaaactt
    42001 ttcaaataat atgtaaatat tcaatacatt catttatgga tgacataaaa aaaggattca
    42061 taactttgag aggaggtcat agagtagggt tagttggaaa agcaatagta gaagatggac
    42121 aagtcaaaaa tataaagcat atatcatctt taaatataag ggtatcaagg gaaattattg
    42181 gatgctcgga taagatttta agtcatatca taaagggaaa aaatcagatt aataatactt
    42241 tgataatatc accacctcaa tgtggaaaaa caactttaat aagagatata gtaagaaatt
    42301 taagtaatgg taatgaagat tatggattta aaggtttaaa agtggcttta gtagatgagc
    42361 gtaatgagat agcaggagct tatctaggtg ttccacaaat ggatgtggga ataaggactg
    42421 atataataga aacttgccca aaagacttgg gtattacaat gcttttaagg tctatgtcac
    42481 caaatgttat tgtgacagat gaaattggaa gtgaaaaaga aataaaggca ttatacacag
    42541 cattaaatgg aggtatagga ttaataacta ctgtgcatgg agattcaata gaggatatac
    42601 aaaatagaaa agaattaaat agacttctgg ataaagagtt atttaaaaag gttataattc
    42661 tttctgcaaa aagaggagca ggaacaattg aaaaaattta tgatttagaa gaaaagagat
    42721 ggtattttgc aaattaaaat aattattata gctttcttga taggaagtag ttatttgata
    42781 ggtgaacaaa tatacaaaac ttatactcgt agacataaac aattaaacga tttaataaga
    42841 gttttagaaa ttttgaggat ggatttatct tttggacttt atacattaga agaaatcttt
    42901 aataggatag gtggaaataa agagttttgt ttttggaaat ttttctatca aatatcagaa
    42961 ggacttcaca atgaacaaag taaaactttg gaaataataa tatcagaaaa tattgatgtc
    43021 ttaagtaaag aaacttatct aggcaataaa gaaattgagg aactgaaaaa tctaatactt
    43081 actttaggga aaagcgatat agagtcacaa caaagaatga tagatttatc tatagaaaat
    43141 ttgaaaaaac aaacctatga gacaaaggaa gatataaaca aaaaaggcgt attgtataaa
    43201 aaattagtga cattcatagg tataggtata tgtattatat tgatttaata tggggaggtt
    43261 tattatggaa atatcattga tattaaaggt tgcaggtgtc ggtattctaa tatcagtatt
    43321 gaatatgata ttggaaaaaa cagatagaaa agattgggca ggtcttacta cattagcagg
    43381 tgtaataatc gtattgggta tggtaataac agaaataagt gacttgttta atactgtaag
    43441 aacaatgttt caactttact aaagaggagg gagtaatttg gaaataatgc aattaatagg
    43501 aattgcaatc atttcaacta cactctgttt agtaattaaa aaagatagac cagagatagc
    43561 aaatttcata gctataataa ctggagtaat aatactattg tcagttatgt ttaagctaaa
    43621 ttttatagta gatagtatac aagatttggc taacaaggct aacatcccga ctatgtatat
    43681 atcattaata ataaaattaa ttgggatagc atacttaatg gaatttgcga tacaactttg
    43741 taaagattgt ggggaaggaa acattgcttc aaaactagaa tttggaggta aaataatagt
    43801 tatgtcaatg tctttcccta tacttttgtc cattgtagaa atggtggtga atataattcc
    43861 atagatgtgt atcttggaat gaatataagt atattagaga gctttcgttg tattgaggtt
    43921 tatagagtga agagaggcat ggttgcttat gaaaaaaaga tttttaccaa tgattatagg
    43981 ttttttattt actttctttt ttgtaaatat ctttgctatt atgatatttg ctaatgaagt
    44041 accaagtagt gaagataaag aatatggtga aacaaaaaat agcatagata agtatataga
    44101 tggtcaatta gacaagctag atataaatga gattcaagac tatataaata aagaaatagt
    44161 tattaatgat gttaatttaa aatcatttgt aaaagattta attagtggag aaaaaaatat
    44221 cttagattta ttcaataaag atggattgaa gatattgatg tttgatgaat ttaaagcaag
    44281 tttaaaggta gtagcagtaa ttttggtact ggctctgtta tcatctattt taaagagtct
    44341 ggaaaactct ttttcatcag gtgcagtaag tcaaatagca acatatataa tatttatcac
    44401 aatggtatca cttacactta ttggttttaa agatgtatta cagatttgct atgatgcaat
    44461 agaccatact gtaggtctta tgcaagttat aatgccaata ttaataacat ttttactttt
    44521 aattggattc ccaataacgt cgactacttt gaatcctatc ttcataggag gagtaacatt
    44581 tataaatgta ttttttaaaa attttctatt tgtatctatt actgttgcat ttggaatttt
    44641 aataataaac aatttatcaa aaaatataag gctaaagaga tttttctcct ttgtaaaaca
    44701 aataaattat gtttctattg gagctatgtt tactgtttac ttaggtcttg tatccataca
    44761 aggactgtat gtaaccagtt ttgataaatt cagtgtaaag actgctaaat ttgctatagg
    44821 taattttatt cctgttgtag gtggatttgt atctgactct gtggatattt tattatcttc
    44881 atctcagctt ataaaaaata tatttggagg aatagggctt atcttacttg ttggaatttg
    44941 cttacttcca gtaataaaaa ttttatcagt aatagtagtg tacaaattag cagcaataat
    45001 tgtagagcct gttggagagg atggaatatc taatttttta aatgaagtgg caaatttaat
    45061 gataataatg ctagcatcag taattgctat aacagtaatg ttctttgtaa ctgtagctat
    45121 cttgacctcg ataagtgtcg taagtcaagg gtaatttata tatcagtgaa aaataattac
    45181 atttaatcta atgtttttag agaggaggat gctatgttag agggcataaa ggcatggata
    45241 gttagtgttt tgataggagc atttatagta aatatagtag atatgatttt accaagttct
    45301 aagataaaac cttatgtcaa cctagtttta aactttatgt ttgtatttat tgtaataact
    45361 ccagtagtag gatttttttc aaaagatatg agtttagaag atagaatatt aaaatctatg
    45421 ggaaactaca acaagcagta tgtagatagt acaaatgctt tggcaaaaga gactggaaat
    45481 aatagtctat ccaagggata tgaggatggg ttaaaagaag tacttaaatt aaaacttgat
    45541 gaatatggtt atgatttaga agatatagag cttaatgggg caaatataaa taatataaaa
    45601 ataaaagaaa agaataatag tgcaaaaagt aataacagtt ccaatgaaga aaataaaaat
    45661 aatagtacta aaagagagga agaaaacata aactctaatg acaaagaaaa ttctaaacaa
    45721 gtcttcaaaa aaggtacaga gtatgggttg aacctaaatg aagaaaaatt aaaaaacgac
    45781 ttaataaagg tgctggatgt ttctatagaa gatatacaaa ttgataaata ggagttggga
    45841 gaatgttgaa aaacttaaat gacaaagata agagaaaggt atattcacta ataactatag
    45901 caggaatatg tgtggtttca ttagtattat tatcttgttt tcctagtagc aaaagcgata
    45961 aacaagttgg aaaaacagag actaataaaa atgctgaaaa gcaagtcact aaagaacaag
    46021 aaaaagatga tttagagtca aaattaacag caatactatc taaaattgat ggtgcaggag
    46081 acgttgatgt aatggttaca tttgaatcaa gtgaagaaat acaacctgct tttaattcaa
    46141 ataatacaac agaaacaaca gaggaaaaag atgcacaagg tggagaaaga acagttacga
    46201 cttctagtga aaataaaaca atgataactt caaattcaag tgaccctgta gttataaaaa
    46261 ctacagagcc aaagataaag ggagtgatag tggtagcaag tggagcaagt gacccaagtg
    46321 ttaaagagac actttatagt gcagtacaaa catcattaca agtagctggt catcaagtag
    46381 aaatatattc taaataaata catataaccg gggggataaa tgaatgaagt ttaattataa
    46441 gggaagagga tttgtaataa taactttaac tgcaatgtta gtggtagtag gaacagtgaa
    46501 ttatcaacta agtaagaaat ctttattaga aacatcaaaa gagtttaagg catatgaaga
    46561 agcacagttg caaaaaaata ctgatgagag tgatagtagt aagacagagg attctagtaa
    46621 tatagataaa caagatggta aggaaagtgc tgatattgat atagttgata gcaaagctag
    46681 taaagtaaaa gaaaaggcaa ctgagacaag taaggaaata aaagctcaat tatcatcaga
    46741 gaaaaatatg aaaaaggcat cttatatttt agatatgaaa atgaatagag aaaaacaaag
    46801 aaatgagtta gttcaagatt taaatgaaat gataaataat ccatctacaa cagaagaatc
    46861 tagaaaagaa gcttctaata tgaaattaaa tatagttaaa attcaagaaa aagaacttca
    46921 aatagaaaac cttttgagta caaaagggta tgaagaagcg ttagtttata taagcgataa
    46981 caaagttaat gtagttgtaa atgaagctaa attagaaaag aaagatgcag caaaaatatt
    47041 tgatttagtt gcagaacaag ccaatgtgaa gtatgaaaat attaaactta caaataataa
    47101 tagtaataag taaagtataa acctcagaat taactgaggt tattttcttg caaagtagac
    47161 ttgtatttgg tattattata cttataaaaa tagttcctta aaatcaggag gtaagtttta
    47221 atatggaaga taataaattt ggacaagtaa aaatatctaa tgatgtaata gctacaatag
    47281 ctggtttagc agcattagaa gttgaaggca tagaaactac agcaacatta acagataagt
    47341 tgttaaaaaa taatggagta aaaatacaaa tcgaagaaga ggatgttaat ttagatgtaa
    47401 tggttacgat aaagtatgga atgtcaatac cagatacagc ttttaaagtt caagaaaatg
    47461 taaaaaatac tgttgagaca atgacaggac tgaaggtttc tcaagtaaat atacacattc
    47521 aaggaatcag ctttaagaag gataaagttg ataaagaaga agcaaaagca actaagaaaa
    47581 attaatatta gccctctgaa aagtcagagg gttttttgct ggtaattgat tttatatgga
    47641 taattaaact taaaggagaa ttttgattga tgaaaaaaga tagggcacaa aagagtacaa
    47701 caagagaata tataatgaaa cttatatacc aaataaatat taataaagaa gattttgaaa
    47761 ctttagaaga taaagtagat aattttttaa aagataattc agaacatatt ataaatagat
    47821 ataaagaact tgcacttcaa tactcaaaaa atacaaattt aaagttagaa gatactgaaa
    47881 ttgaagatgt tatagacaaa aaatatataa atacagtatg caaagcattg aaagaaaatc
    47941 atgacaaaat agatgagtta ataaataagc atgctaaaaa ctggacagta gatagaatgc
    48001 caaaggtaga tgtttctata cttagattgt ctgtgtgtga aatactttat ttagacactc
    48061 ctaataaagt atcaataaat gaagcagtag aacttgcaaa aatatattgt gatgataagt
    48121 ctcctaaatt tataaatggt atattgggaa gtgttgttga tgaaattggg aaataatata
    48181 ataattggaa ttgatactag ctgctatact acttctatag cagctatctc tttagataag
    48241 aaagttatat tcaatgaaaa aataatgtta gaagtaaggg ataattcaaa aggtttaagg
    48301 caaagtgaag ctgtatttca acatatcaat aatttaggga ttcttagtga taggataaaa
    48361 tcttttaaag ataagtttaa tgtagaagga gtttgctcat caaaaaaacc gagacctgtt
    48421 gaaaactcat atatgcctgt attcaatgta ggtcataatt ttggaaaatt attgtctagt
    48481 atatatggtt gtaggtttta tgagactact catcaagaga atcatattga agcaagttta
    48541 ttaaatagta aattaaaaaa taataataaa tttatttctg ttcatatgtc tggtggtact
    48601 acagagatac ttttaacaag caaacaagat agtcatcaca atgtatgtga tactaattta
    48661 ggtaaaattg ccaaaataag tattaaaaaa gatgataaaa gtaagttata caataatttt
    48721 ggatataata tagatataat tggaggaagt aaagatatta gctttggtca acttatagat
    48781 agagtaggaa ttaagcttgg atataaattt ccttcaggaa agtatttgga tgaaaatgct
    48841 ttaaattgta atcttaaaat agaaagtggt ctgaaaactt ctgtaagaga tgggtatatg
    48901 aatttatcag gattagaaaa tcaggtaaat aagattataa atgataatgg atataatact
    48961 aatcaaaaag aatatatatc taaattggta ttagattcag tagttagaaa tatgtttaaa
    49021 tctttagtgt atttatgtga aacttataat gtaaatgaag tagtatttgc tggtggagtt
    49081 tctgcaagta agtatattct tagagaatta agcgtgaagt taagaaaaaa gcatatagaa
    49141 gcttatttta cagaaccaca atattcaact gataatgctg tcgggtgtgc tataatagga
    49201 ttgaataact ttttaggaga aagagtatga aactaagagc tttagatata agtgaagcaa
    49261 actcatatat taaaagaatt ttaataaacg acccaatact ttctaatctt aaagttaaag
    49321 gagaaatttc taattttaag gttcatagta gtgggaatgt atatttatca cttaaagatg
    49381 aaacatcaaa gttaaactgt gtaattttta aaagtaattt taatcgcaat ttaaaattag
    49441 ataatggtgt aaaaattata gctaatggat atatatcagt ctatgaaaga gatggtgcgt
    49501 atcaattata cattaatgaa attgaaatag agggaatagg aaatttgcac atagagttta
    49561 atagattaaa ggaaaaactt aataaagaag gattatttga ccctaaatac aagataccta
    49621 tacctaaaat gccaaactca attggcgtta taacatctcc aacaggtgct gttataagag
    49681 atataataaa tgtaataaaa agaagatatc cgaaagttaa tataaagctt tatccagtaa
    49741 cggttcaagg agataaatca gctgaagaaa tctgtgaagc aattagattt ttcaatcata
    49801 tgaagaatgt tgatacactt atagttggta gaggtggggg ttcaatagaa gaactttggt
    49861 cttttaatga tgaaatggta gcaagagagg tttttaattc tcaaattccg ataatatcag
    49921 cagttgggca tgaaacggat tttactattt gtgactttgt gtctgatatg agagccccaa
    49981 cgccatcagc agcagctgag attgctactc catcattgga tgatataaac tataaacttg
    50041 gaaacataaa aagtaggatg agtaagtctc ttacaaatca aatagagcta gaccaatata
    50101 ggttagaaac agtatttaat aagataaata actatttaga ttcgtacaca ataaaagata
    50161 aagttataca attagacaaa atatatgata aaataatttt tggaatagaa aataatttaa
    50221 aattagaaga tgaaaaatta gtaaaaattg gagcattact ccataattta agtccattag
    50281 ctactatgga tagaggttat agtataactc aaaaaaatgg aaaagtaata aatagtataa
    50341 aaggattaaa aataaaggat agtatagata tagtattaaa agatggaaat ttagaatgta
    50401 tgatagataa aattgaaaat aaagagggat agtatgaatt taacctacga agaagcttat
    50461 aaaagattag aaagtatttt aagtgaatta gaatctaaaa atgctagctt ggatgaatct
    50521 ttaagcctat atgaagaagg tataagcctt tataaacatt gtaataagct tttagatgat
    50581 gctaaattga aaataagtaa atttaatcaa ttgggaatag aagaagactt taaaatagag
    50641 gaggaataaa attggaattt aaacaatgtc taaaagaaaa agcaagtttt gtagaaaaag
    50701 tacttaaaga atatatgcct aaagaagaag ggtatcaaaa aactgttatt gaagctatga
    50761 actatagctt aagtgctgga ggtaaaagat taagaccaat acttacattg gaggcttgta
    50821 aaatagttgg aggtaatgaa gatgaagcta ttccttttgc tattgcaatt gaaatgatac
    50881 atacatattc actaatacat gatgatttgc cagctcttga taatgatgat ttaagaagag
    50941 gaagaccaac aaatcataaa gtatatggag aagctatggg gattttagca ggagatgctt
    51001 tgttaaacta tgcttttgaa gtaatgcttg caggctcaat caataaagaa aatccagaaa
    51061 agtatctaaa agctataaat gaaattgcca aaggtgctgg tatatatgga atgataggtg
    51121 gtcaagtagt agatgtagaa agcgaaaata aacaaattga aaaagaaaaa ttagattata
    51181 tacatatgaa taaaactgct gcaatgatgg taggctgtat gagagcagga gctactatag
    51241 gtggagcaaa ttctgaacaa atggaagaaa taactaaata tgcaaaaaat atcggattat
    51301 cattccagat agtagatgat atactagaca tagtaggaga tgaagctaag ttaggtaaaa
    51361 aggttggaag tgatatagaa aatcataagt caacataccc atctctttta ggtttagata
    51421 aatctaaaga aattgcacat aatttgattg atgaagcaaa gaaaagtata gaaaaattat
    51481 ctgatgatgt agatttttta aagggattgg ctgaatatat aatagataga gaatactaaa
    51541 atatacagct aaaatcgagg agggaaaaat ggattttttt tcggagattt ttaacaatgg
    51601 ggctttggga ataagtctga ttgcttgttt cttagcacaa tttataaaaa tatttactgg
    51661 taaggaaaaa agaattgagt tatcaagaat acttatttca ggaggtatgc ctagttccca
    51721 tagttctttt gttacaagtt tagctacagt ggtaggtatt gaaaaagggt ttaattctac
    51781 tgattttgct ataattaccg tgcttgcctt aattataatg tatgatgcag caggtgttag
    51841 acgggctgtt ggtaaacaag ctactatatt aaatcaaatg gtggcagata tacagcatgg
    51901 aaagcatata gagcagaaga aattaaaaga attaataggt catacaccac tagaagtttg
    51961 gtttggagct ttacttggaa tagtaacagc tttaatattg atgtaaattg aaaatttaca
    52021 gaataaaggt gaggataata tgtataaata tttagataaa gtaaattctc caaaggatat
    52081 aaaaaatatg agtatagaag aaatggattt acttgcaaag gatataagaa agttcttagt
    52141 aaaatctgtt tcaaagacag gaggacactt agcttctaat ctaggagtgg ttgagttaac
    52201 attagcactt cataaagtat ttgatagccc taaagataag attgtatggg atgtagggca
    52261 tcaatcttat gttcataaaa tagttactgg aagaaaagat tgttttgtat ctttgagaca
    52321 gtttaatgga ctaagtggtt ttccaaagga gaatgaaagt cctcatgata tttttgatac
    52381 aggacatagc agtacatcta tttctatagc tacaggtatt gcctgtgcta gggatataaa
    52441 aaaagaaaac tatagtgtta tatctgtgat aggagatggt tctataacag gaggtatggc
    52501 acttgaagct ttaaatcaat taggatatat agataccaat atgatagtaa tccttaatga
    52561 taatgagatg tccatagata aaaatgttgg aggaatgtct aaatatctgt caagtattat
    52621 aagaaactca acagttgaga aaatgacaga tgaagttgat aaaattttaa atgttacaca
    52681 aacaggtgaa attttatcta agactgcaca tagatttaaa gataaactaa tgtatagctt
    52741 ttctcctcag gactgttcat tttttgattc attaggtata agatattatg gacctataga
    52801 tggccataat actaaagaac taatagatat attgagaaaa gctaaacaca aaaaagggcc
    52861 tgttctttta catgtaatta cgaaaaaagg aaaagggtac agatttgcag aagaacaacc
    52921 tgataaatat catggagtat caaagtttga tataaagaca ggtgttacat ctgcaaaagt
    52981 taagtctatg tcaattagtg ttggagaaaa acttgttgat atggctaata gtaatgaaaa
    53041 tatagtagca ataacagctg caatgccatc tggtacaggg ttaaacctgt ttgaaagtgc
    53101 atatccaaaa agatattatg atgttggtat agctgaacaa catgcaacag gatttgcagc
    53161 aggtcttgca aaaaatggta tgaaacctta ctttgctgtg tactcatcat ttttgcaaag
    53221 ggcatatgac caagttattc atgatgtatg cataacaaaa aagccagtta cttttcttat
    53281 agatagagct ggattagttg gaaatgatgg agaaactcat catggtatgt ttgatttaag
    53341 ttacttaaat tctattccaa atattgtagt aatggctcca aaagacacaa gagagatgga
    53401 gcttatgatg gatttgtcat taaaattaga ttgtccacta gcaattagat acccaagagg
    53461 aagtagttat tacctagata agggagagta tggagagatt gtactgggta aatatgaggt
    53521 attagatgac ggtcaagata cagtcatact ttgtattgga agtatggtaa aacatgcttt
    53581 agaggctaaa gaaatattat caagagaagg aataaatccg acaatagtta atgctagatt
    53641 cttaaagcca attgatgaag gtatgttaaa agcattatta aaaaatcata aaaatgtagt
    53701 tactatagag gataatattg taactggagg atttggaagt agaataaata agtttattat
    53761 agataatgaa tataacgtaa atatacttaa tatagcaata ccagaagaat ttgtaaaaca
    53821 tggcaatata gatgaattat atgattttgt aggattatcg ccaaaaagta ttgctgataa
    53881 aataaggaaa ttagttattg agtaaaaatc taatgtagat attgtaaatt aaaatttata
    53941 taaaatatag aatttatcaa ttagaataaa tatcaagtgt gttacttcaa gctactttag
    54001 ttatcattaa agtagctttt aacagaaagg taattgtatg aaaaaaagaa tagatttatt
    54061 attagtagaa caagggtact ttgaaagtag agaaagagcc aaaaaagcaa taatggctgg
    54121 attggttttt gttgataatc aaaggtgtga taaggctggt acagaagtaa aagaagattg
    54181 tagtatagaa gtaaaaggaa atccaatacc atatgtcagt agaggtggtt taaagcttga
    54241 aaaagcaatg aaaaactttg atttgactat tgatggaaag gtatgtatgg atataggggc
    54301 atccacaggt ggttttacag attgtatgct caaaaatgga gcaataaaag tattttctat
    54361 agatgttggt tatggtcaac ttgcatggaa attgagacaa gatgataggg ttgtgtgtat
    54421 ggaaagaacc aatataagaa atgtgacaat agaagataca aagcagtttg ctgattttgc
    54481 gtcaattgat gtgtctttta tatcgttaaa gttagtactt ccaaaggcaa aggagttagt
    54541 acgtcatgat ggggaagttg tcgctttaat taaacctcaa tttgaagcag gaagagaaaa
    54601 agtaggtaaa aaaggagtag ttagagaaaa atctacacat atagaagtta taaaaatgat
    54661 ttctgatttc tcagtcgaaa atggatttga gattttaggg ttagattttt ctcctattaa
    54721 aggtcctgaa ggtaatatag aatatctaat tcatttgaga aatggaaatg aaggatatga
    54781 atttgatggt gagacataca ataacaaaat agtagaagtt gttgaagctt ctcataattt
    54841 agacaaatag gttaaaaggg ggcttagatt tgatcctcga attatatatg aaaaattgtg
    54901 ccttagttga agaactaagg ttgaatattg ataaaaactt aaatatactt acaggtgaaa
    54961 ctggttcagg aaaatctata ataatagatg cacttggact ttgtttaggt gataaatatg
    55021 ataggtcttt tttaagaaaa ggaacagata agggacttgt tgaggctgta tttttttcag
    55081 acaatagata tcttaaaaaa atattagaag aaaatgatat aagtatggaa gatgataatt
    55141 tattggtaat aactaggttg atatactcag atggtaagag tactgctaga gtaaatggaa
    55201 ggactgttaa agtgtctctt cttaaagaaa ttgcatctac acttatagat atacatggtc
    55261 aacatcaaaa tcaagctttg tttaataaag atactcattt aaaatttcta gacctttttg
    55321 gagaaaatga attggaagag tttaaaattg cttataaaaa tgtgtaccat aagtatagtg
    55381 aagtaaaaaa agctttaaat tgcttgacag aaaataaaga tgagatgcaa attcaacgag
    55441 aaatagattt attaagattt caaataaatg aaattgaagc tgcaaatcta aataagaatg
    55501 aatatgaaga tttattaaaa caaagagaag tttatagaaa tagtgaaaag atatataata
    55561 atctaaattc gagttatagc aagttacata atggtgagta taatgttatt gacctaatag
    55621 gtcttgcatc taaggaactt aatgacatat ctaaatatga cagtgtttta agtgaatata
    55681 gtgatactgt agaaagaatc atgtatgagt tacaagacat atctggtgag ataagaaatt
    55741 acaaagataa tatagacttt gaaccttatg agctagagca gattgagctt agaatcgacg
    55801 agattaataa cttaagaaga aaatatggag acagtataga tgatatattt gagtattatg
    55861 gaaaaattaa agatagatta gatgaaatat taaacagaga tgaaagagtt gaacagttaa
    55921 gaagcaaact gatgaatata gaagaagatt taaaaataaa agccagtaaa ttgactaaag
    55981 caagaataga agtagcaact actttagaaa aaatacttct tgatgaatta aaaagcttaa
    56041 atatgaaaaa tgtaatgttc aaggttaatt ttgaaaaagg tccatttact ttagatggag
    56101 tagatgatat tgaatttatg atatctttta acttaggaga agatattaag cctatatata
    56161 aagttgcatc aggtggtgag atgtccagat ttatgttagc gtttaaaacc atattggctg
    56221 atatagatga tattgataca ttagtgtttg acgagataga tactggaata agtgggatag
    56281 cagcacagat agttggtgag aaattgagtg atatagcaaa gaaaaaacag ataatatgta
    56341 taactcattt acctcaaatt gctgcaaatg cagacactca ttattgtata gagaaagata
    56401 cttcaaataa taggacgttt accaatgtta gtaagttaaa tgaatctcaa cgaaaaaatg
    56461 aaattgccag acttatagca ggtaacaata taacagaaaa aactattgaa catgcaagtg
    56521 aaattattga gttggctaaa aaatgttagt gaaaaacaag cattttaata ggtgtaaaga
    56581 atttttatag aaatgcttta catctatttt ttatgatgaa attattttaa aatatctagt
    56641 gcctatattg aagaaaagta gatttaaaaa tagaagaaaa tttgtataaa tttgtaactt
    56701 tgaaatttct aaatgcttaa gtataatatt atttattaag gtagtagtga gggggacata
    56761 aaatgaataa aaaagatact atgcacttaa tttttacaat tgtaattttt attttattat
    56821 ggtatattgt ggtagcagta agtgagatta ataaaaatat tgaaagttgt agtaataaat
    56881 tagattattt gtcacaagag attatgagta ctaaatcgga tattagtaat actataaatg
    56941 aagaaatgtc aaaaagttat ataacaaaga gtattgactt aaaagtaaaa aaaatcgaga
    57001 aaaaagagtg tgttattgat gtagatgttc aattaagtaa acttggaaaa aatggaaaag
    57061 tattttttat gtataaagaa gatagtgata aatggaatga aactgagatg acaaaacatg
    57121 gagaattatc atatgcatgt gaaattaaga taaatacagg aagtgaatat gactataaag
    57181 tagttacaag tggagctata tctgaaagtt ctgatgtgca aaaattgact aaatctgatt
    57241 atatgcctga acaacccata tttaattctg ggataagaga taatagagaa tactttattg
    57301 aaatagtaga aaatagtaat cttttcaatc atgagagtga aaagtcaaaa aataaagttt
    57361 atgataatat tagattagaa aaagtagata ttattgtaaa tgaaggaaaa aaagacacta
    57421 tatacaaagc caaattagct gaaggcttag atgatggcaa aactaataat tcaaatagaa
    57481 atcaagtgaa ttatgaagta agttttccta aaagggatat tgatgacata atttatatta
    57541 aagctaaact tacatacaat aatggagtag aatatacaaa ggatataact gaagatataa
    57601 ctatgggatt acaagattta gaaaaataaa tacatattta aataaatatt caaatagatt
    57661 tgttcaataa aatagagtat aaataaaact gtagtagttt tacttatact ctattaaaaa
    57721 attataattt taattccata tatctagccc cttcaattgg attataagta taaggttcta
    57781 tatcataaaa accaaacttt tcatataatc cttgtgcact tttcatgctt ggaagagtat
    57841 ctaatctcat gtgtgtatat ccaaattttt tagcttcttc aatgatttct tccaatagta
    57901 tttttcctat ttttaatcct ctaaattgat ttcttacata taatcttttt aattcacata
    57961 ttttaccttc aagttttttt aaagcaacac aacctgccaa attttcatca acaaatgcca
    58021 atatcaatga gcctgaaggt tttttatatt ttcctggaag tgtttttaat tcattattaa
    58081 agtcttgaaa acataagtct atatttagag aatttgaata ttcagtaaat agaagtttta
    58141 cgttttcaag gttttctaaa tctttttctt caacaaattg taaagttata ttttgagcca
    58201 ttttatccgc cattatataa acatgtttat ataatgactt cacctccttg atatatgtat
    58261 atttttctta atatcaatta gattttaata ccattacttt ttcaccacca tagtcaagct
    58321 ctccattaaa ctcaaatcca aaatctttat aaagcttaat agccatttta ttgtcttcga
    58381 atatactaag atatagttca tcacagttat attcattttt aagatgattt acaagaaaat
    58441 ctaatgatgc ttttccatat cctttacctt gatattttga atcaatcata aatctatcaa
    58501 gccaaactct atcatcttct aaacgaccat acatagcaaa tcctattaaa gaattttcat
    58561 catatattcc aacaggtacc caagctgtta taaatttaga ttcagcaata gaaagtgcat
    58621 tgctttctat ataatctaac tgacttttat ctacagacaa actaactaaa tcatgccaat
    58681 tatttatgtc tgcaattctt acatttaatt tcaagatatt accgcccttc aaactttttg
    58741 ttacaatcta atactatcat attatgtatt aaaaatcact tattaagatt ttaaataaac
    58801 tttttaaatg aataaattct caggaaaaag gaattataaa tacataataa tacagcatag
    58861 gagtagatgg atatatgaac aaaataaata aaaatttcaa aaatatttgg ataatattag
    58921 gagctgtatc gatttttacc atggttataa tttttaataa aaattgtaat gttaataaag
    58981 agactcaaat agaagctttt acaattaaga atcatgataa aaaatttgta tatcctatgg
    59041 gaaatataat tggagtaaaa gcaaatacag atggtgtatt ggtcttagga tatgaggaag
    59101 aggatgtaga ctatattgga ggcatacaaa tcggtgataa tatagtaaaa atagataata
    59161 aaaggataaa aaatagtcaa gatgtatcag agattttgaa taagattaaa aaaagtaaag
    59221 ttgaagtgac ttttgagaga aaaaataagt ataaaacaga agtaatagag actaaaaaag
    59281 aaaatggcaa gtataaactt ggattatggg taagagataa aatatctgga attggaacta
    59341 tgacttttta cgaccctagt atggaaaagt tcaaagcaat cggtcatgcc ataaaagatt
    59401 cggatactaa tgaactatta aagataaagc aaggatatat atataagcca gaacaattaa
    59461 aaatagtaaa agctagtaat gaaaaagtag gtaaaataaa aggagatttt aatgacagca
    59521 atttaatggg taatttctca aataattcag agttaggtat aagtggtaat attacagaaa
    59581 accataataa agagtttaat gtagcaaata aagaaaagca attaatagaa gttggaagac
    59641 cgcaagatgt aaaaatagga gatgcagtaa ttctttttga ggataaaaac aaaaatataa
    59701 caagctatga tataaaaata gaaagtatag tatatgataa aggaaattat agagatatgg
    59761 taataaaagt agtagatgac aagttattgg aatacacagg aggtatcgta caggggatga
    59821 gtggagctcc aataatacaa aataataaaa ttattggtgc aataactcat gtttttagag
    59881 ataatccgaa aaaaggatat ggtattttta tagatgaaat gataaaattg taggtgaggc
    59941 attaaaaaat tttattattt tatcaattat ctaggaggaa tataattttg gagtgtcgaa
    60001 tatgctttag agtagataat taggaagcaa ttgtgtaaaa agtttagttt tctgtaataa
    60061 gaagatgttt tttaatgggg ggatttttag tggaaaaaat caaaatagtt ttagcagatg
    60121 acaataagga tttttgtcag gtattaaaag agtatttgtc taatgaagat gatatcgata
    60181 tattaggcat agctaaggat ggaattgaag cattagactt agtaaaaaag acacaaccgg
    60241 acttattaat actagatgta ataatgccac atctagatgg attaggtgta attgaaaaat
    60301 tgaatactat ggatatacct aaaatgccaa aaataatagt actatcagca gtaggtcaag
    60361 ataagataac tcaaagcgca ataaatctag gagcagatta ctacatagta aagccatttg
    60421 attttgttgt gtttataaac agaattagag agctagtttc taatagagtt acacaagttg
    60481 agccaaaacc tagaccagtt caagagactc aaatgactag aagtgatttt gttaagaatg
    60541 taggaaatat agagacagaa atcacaaata taatacatga aataggaata ccagctcata
    60601 taaaaggata tttatattta agagaagcaa taaaaatggt tattgataat gttgagcttt
    60661 taggtgcagt aacaaaagag ttatatccaa gtatagctaa aaaattcaat acaacaccaa
    60721 gtagagttga aagagcaata agacatgcaa tagaggttgc atggagtaga ggaaaagttg
    60781 acacaataaa tcaattattt ggatatacgg tacacaatac taaaggaaaa ccaactaatt
    60841 cagaatttat agcaatgatt gctgataaat taagactaga acatagtatg gttaaataaa
    60901 caagacataa aaagtaaggc tttttaatta aggcattggc tataaatgcg tattacaagc
    60961 agcgaaacgg tataaccact agggttatac cgtttcgcta ttttaataaa tataaaaatt
    61021 ttctttatta tttgcttact atatcaatat aataatttta ttatactatg gatatagtat
    61081 gtgtctttac aagttgtaaa ctgacagtgg tttatttttt aatataaata ttgactttga
    61141 tgcaggtaaa ctttgtattt ttaagcgtat tatggaatat gttaaataaa aaaatgatga
    61201 aatatagtat tgtaaatgcc aaagatgcaa aacaaactta aaacatttat tttattgtta
    61261 agtaatgcta taatataatg tgattttaat aatgatagtg gaggtttaaa tatgagagtc
    61321 gaggccccta taaaagtaga tcgaaaaacc aaaaaacttg ctaaaagagt tgaaagtggg
    61381 gaaatagcag ttataaatca tatagacata gatgaagttg ctgcaaactc tttagtagaa
    61441 gctaaaataa aacttgtcat aaatgcggct ccttctataa gtggtaggta tcccaataaa
    61501 ggtccaggga tattaactga aaataatata ctaataattg ataatgttgg agaagagtta
    61561 tttgaagaat taaaagaagg agaaactata gaagttgtag atggaaagat atatagaaaa
    61621 ggaaaatttt taggtgcagg agaagtttta gacaagtatg aggtttcaca ccaaataaag
    61681 gctgcctatg agaatttagc tgtagaattg gatagattta tagataatac tatagattat
    61741 gctaaaaaag aaaaaggatt tatacttgga gaagtagaaa ttccaaaagt gaaaactaat
    61801 tatgctaata aacatgtatt gatagttgta agaggtcagg actacaaaga agatttaagt
    61861 actatgcttt cttatataga agaggtaaag ccagtattgg ttggtgttga tggaggagca
    61921 gacgctttaa ttgagtttgg atatactcca gatgtgattg taggtgatat ggatagtgta
    61981 agtgatgaag ctttaaaaaa ggctagtgaa atagtagtac atgcttatac agatggaaga
    62041 gcaccaggtc ttaaaagggt tgaggaatta ggcttagatg cagttgtatt tcctgcacca
    62101 ggaactagtg aagatatagc tatgcttatc gcttatgagt ataaggctga gttaatagta
    62161 gcagttggta cacattcaaa tatgattgat tttcttgaaa aaggaagaaa aggtatggca
    62221 agtacttttt tagttagact aaaaataggt tcaaagctta tagatgctaa aggcgttaat
    62281 ttgttataca gaagtaaatt aaaaataaag tacatatggg cattaatagc aacagcatta
    62341 tttcctgtgt tggtagttgc atcattgtca ccaggagttc aacagttcat acaactaatg
    62401 caattaaagt ttagagtatt attacagatg taaattttag gaggataaat atgcatatta
    62461 atatgaaata ttatatagtc actatagggg ctatatttat agctttgggt ataggcatgt
    62521 tagtaggatt taatttaaat aataatcaac aattaagtga acaacaagca aatataataa
    62581 atgatttgga tgataagttt gatatcttaa aagaaaaaaa tgataaactt gacagtgact
    62641 tagcaagtgt aaatagagat tatgaagagg cagttaattt tataaataaa aatgtagata
    62701 agattttagc tggttcgctg aatggtaaga gtataggaat aatatctgct aatgaaaatg
    62761 acgattatac aaaaaatata gaagacataa taaataaatc taatggaagc attgcattta
    62821 atataatatt aaaagaaaac ataacaaatc cagaaaagtt aaaggaaatg tcaactaaac
    62881 taggtacaga tgtaaaaaat gcaaatgatg cagttaatta tataattgac actcttaaaa
    62941 aggaagatgc aagtgacatt ttaacatatc ttcaagaact agatgtaata aagtttaatt
    63001 ttattggaga tacatatcta aaatatgatt ccgttgtaat agctggtgga aatgatgcaa
    63061 aagacagtgc aaaacagttt gaaaaaatag aaaaatttgt agtttcaaaa cttaaatcag
    63121 agaataaata tttagtagaa gttcaaaata caggagttaa aacttcttat gtagaactat
    63181 attctaaaaa caaagttgca actatagaca atattgatga aggtatagga agtatatctc
    63241 tagcgattct tctacaacaa ggtaatatag ttggtaattt tggtagattg gatactgcaa
    63301 cttcattgtt gccatctatt aaatagaaat aattttaagg agagaaaaaa tggattctta
    63361 tataagtata ataataccag cttataatga agaaagtaga ataaaatata cattagaaag
    63421 catattggac attaagcaaa taaatgaaat aatagttgtg gatgatggtt caattgacaa
    63481 tactgctaag gttgtatctg agctagaaaa tgaaaagatt aaatttttta agttagataa
    63541 aaatagaggt aaaggatatg ctttaaatta tggtatcaaa ttagcaatga aaaatgcaga
    63601 tattataggt tttctggatg gagatttagg aagttctgct aaagaagttg aaaaattaat
    63661 agtacctata ttaaatggtg aggcggatgt tacaatagcc aagtttcctc ctgcaaagag
    63721 aaaaggaggt ttgggatttg taaaaggttt agctaaaaat tctgtgtttg agatgactgg
    63781 tgttgagtta gatgcaactt tgtcaggtca aagaatattt aaaagagaag ttttagaaaa
    63841 gtttgatgaa ataccttttg gatatggagt agaagttgga atgaccattg atatattaaa
    63901 gtatggattt aaaattaaag aagtattagt aaatatgact cataatgaaa caggaagaaa
    63961 tttaaaaggt tttattcata gagggaaaca gtattatcac ataaaaaagg ttttaggaca
    64021 aaaaaagaaa gaatggaggt aatatcttag tgaaagatta tatactttat accattttat
    64081 tattaactgg attatttgga acctatgctg taattccact atttaaaaat ttattgataa
    64141 atggaaatgt acttagacca aactataaaa aagatatgat accagtaagt atgggaattg
    64201 tatttttgcc tatgattgta atcaatggaa taatacttgc tttctttact acagaattta
    64261 aggatttagc gtatatattt atgtttatgt ttggtatgat atccatgttt tttgcaggga
    64321 tactagatga tgtcattgga aatagagatg taagtggttt aaaggggcat tttaaaagtt
    64381 tatttaaagg aagtcttaca acaggaggtt ttaaagcttt atttggtgga tttgtagggc
    64441 ttatagtttc tgttgctata tcaaaagaca taattgatat aatagtaaat acactaataa
    64501 tagctctatc aactaattta atgaatcttt tggatttaag accaggaagg gcaataaaag
    64561 catatttatt cataatggta attatatttt taacattgac aggatttgtt caagttcttc
    64621 cattacttat agtaccaaat gtacttgcat actttaatta tgatttaaaa gcaagggcta
    64681 tgatgggaga tactggttca aacgttcttg gaatatctat tggaatgctc atttcttttg
    64741 ggtatccatt taacattaga ttaggatggt taatatttgt agttattatg catatattca
    64801 ctgagaaata ctcattaact aagataatag aaaaaaataa actattaaat tttatagata
    64861 aattgggaag gtagtattat gataagcaaa agagtgggga ttgttgaatc aatagtaagt
    64921 caaactgaaa ctctagatga tataagagta aatataaatg gagaaataca aaaggcatat
    64981 aattatccaa aaatatctgg aactataaat ataggtgacg aagtggtttt aaatacaaca
    65041 gcagtagaac tgagcttagg tacaggtgga taccattttg taataactaa tttaaataat
    65101 atagaatcta ctttaactga aggtggacat ataatgaaac ttagatatac gcctcttcaa
    65161 ataaaagtgg attctgttga ggaacaagaa agtatttatc atgataaatt tgcgaatttt
    65221 aaaggattag aaggtctttc tgttgtagta gggactcttc atagtatgtt aactccattt
    65281 gcagcttcat ttaaaagaaa taatccaaat aaaaaattag tgtatataat gactgacgga
    65341 gcatctcttc caatttattt aagtaaaaat gtggatactt taaaagaaaa aaaattaata
    65401 gatagtacaa taactatagg aaatgcgttt ggtggagatt atgaatgtat aaatatatat
    65461 actgcattaa ttacagcaaa agaaatacta aaagcggatg cagtatttgt cagtatggga
    65521 cctggaattg ctgggacagg aacaaaatat ggatttacag ggattgaaca aggctctatt
    65581 cttgatgccg taaaaaaact tgaaggaaga gcaattgcaa ttccaagaat tagttttgct
    65641 gacaaacgag aaagacatca aggtatttca catcatagta tgactgtatt taaagaaatt
    65701 gtaaatgtaa atgtagacat accaataact atatatgatg atgaaaaatt gaactttata
    65761 aaagagcaaa tcaatttaaa tggtttagac aaaaagcata atataattta tatagataat
    65821 aataaaacga aagaggattt agactatttt aatctaaaag taaagagtat gggaagaaat
    65881 tatgaacaag atgaggcatt tttcaaagct gcaagcacag cagcatatta cttaatggag
    65941 gtttaagatg gtattagaag aaaaaactat tagtagtgat agggtttata caggtaaagt
    66001 aattacttta aaggttgata ctgttgaaat tccagggcaa ggatatcaaa aaagggagtt
    66061 agtagaagtt ggtggagcag taggaatagt tgcaatcaca gatgataata aagttgtgtt
    66121 agttaagcaa tttagaaaac ctatagaaaa gccaatcttt gaaattccag ctggtaaact
    66181 agaaaaaaat gaaagtccaa aagaatgtgc tgaaagagaa ttaaaagaag aaactgggta
    66241 tagtgcaaaa aatattaagc taatacataa atttttcact tcagcaggtt tttctaatga
    66301 gataatgttt gtatatttag caacaggtct tactccagga gagaataatt tagatgcaga
    66361 tgagttttta gatgtctatg aaattgagct tgaagaagca tataacatgg tattaaaaaa
    66421 tgacgttgaa gatgcaaaaa catctattgg attattatta gtaaaagata tgtttaaaaa
    66481 ttaatattta taaaatgaat aaccctttgt cctaaagcat attattttat aaaggacaag
    66541 ggggaattaa attgagaaga acatatagaa aaaatgattt tagagaatta aatagacaaa
    66601 taattattat aggattgttg tttatgatgt ctattgttgt tgggtcttac ataaataaaa
    66661 tattgccagg ttctagtaac aatatattaa acaatataaa tcctgctgta gagtattata
    66721 atctaaatat aagcataaaa gatacagtga tacaaaattt aaaatcagat gcaatcttta
    66781 tgggctcaat agctctatta agtctatttg tagtaacaat tccagcagtg ttggtagctt
    66841 ttgtattaaa agggatgtca attggttata caataaatag ttgtatattg gcattaaaat
    66901 ttaaaagtat aaaaatgatt ttaataatat tatttaaaaa tttgattatt attccatgtg
    66961 caatcatatt agcattaatt agtttaagtt attttaaaga aatggtttat gaatttaaaa
    67021 agaaaaatag aaaaaatatg caatttttaa ttaagaggta tatactaaat attataatta
    67081 taatagcact atcattgggg ttgcaattaa tattaaatac tgcaagtatt ggtattatta
    67141 agttcctagc taaataaagg agtttataat ggatattata gagggatata tagattacat
    67201 aaaagataaa aaaaaattat cagagaatac agtggcatca tactttatgg atataaaaaa
    67261 atatatggaa tatataaatc aaaaaagcat taaactagta gatatagtag aaaatgatat
    67321 tataagttac ttaataaagt tggaaaaaga taatgtatca atagctacaa tagcgaggat
    67381 gatatcctct ataaaatctt ttcatgatta tttattttta aatcatatat gtacaaataa
    67441 tcctgcaaag gatataaaaa aacctaaaat aaaaaaagaa aatataaata tacttacaga
    67501 agaagaaatt gaaagactat taaattttcc aaagttaaca acacctaaat tgattaggga
    67561 caaggctatt tttgaagtat tatatggtac tggtataaaa gtatctgaat tagtagagat
    67621 gaatatagag gatattgacc tagatattga ttatatatat tgtaattcat gttgtaaaaa
    67681 tcaaagagtg ataccacttt gtgatattac aaaactttac ttagaaaagt atctaaaaga
    67741 agcaagacct aaaatggctg tagaaggtga aaaatcatta ttcgtaagtt cattaggtca
    67801 aaggtttaca cgacaaggtc tttggaaagt cataaaaaaa tattctaatc tagccaatat
    67861 agataaaaat ataaatccta caatgcttag acattcattt gctattcatt tgttaaatga
    67921 aggtgctaac attgctgttg taagtaaaat tttaggaaat gttaatttat ctagtttgca
    67981 agtatattta aatcatatag ataaaaacgt gagaagagaa ataaaggaga aacatcctag
    68041 aaatgatgtt gatgtagaat tacaaaaagc agaagctaaa tagactatat agcaaatttt
    68101 ataatttaga aggagcatat ttatatgagc agagtaattt ggattgtaat tgatagtgtt
    68161 gggataggag cattgcctga tgctgaaaaa tttggtgata gtaaggatgt aagtaccctt
    68221 ggaaatatat ttaaggaata tccagatatt cagattccta atatgagaaa tttaggtata
    68281 ggaaacatag atggtataga tttttttgaa agtataaaag aaccaatagg ttgttttgga
    68341 aagtgtaagg aaatgtctca gggaaaagat actactacag gtcattggga aatgactggt
    68401 ataatagttg acaaaccatt taagacattt gaacatggat tctctaagga gataatagaa
    68461 gagtttgaga aaaaaactgg aagaaaagta gtaggaaata aaccagcttc aggaactgta
    68521 ataatagatg agtatggaga acatcaaata aaaactggag atgtaatagt atatacatca
    68581 gctgatagtg tatttcagat tgctgctaat gaagaagtaa ttcccctaga agaactctat
    68641 aatatgtgca aaatcgctag ggaaataatg atgggggata atgcagtagc tagagtaatt
    68701 gctagaccat tcataggtaa gaaaaaaggt gagtttgtga ggacttcaaa tagaagagat
    68761 tattcactag acccatttga accaacagtt cttgataata taaaagaatc aggacttgat
    68821 gttttagcag ttggaaaaat agaagatatt tttaatggaa aaggaattac agatgctatc
    68881 cacactaaaa gcaatatgga tggagtggat gaaactttaa attatatgaa acaagataat
    68941 aaaggtctaa tatattcaaa tctcgttgat tttgattcta aatatggtca taggagagac
    69001 ccagaaggat ataagaaagc tcttgaagag tttgatagta gacttcctga aataatggct
    69061 aatatgagag aagatgatat tttaataatc aatgcagacc atggaaatga cccaacatat
    69121 aaaggtacag accatacaag agaatatata cctgttatga tttatggcaa taagattaaa
    69181 aaaggtttta atttaggagt aaaagatact tttgctgata ttggagcaac tgttgcagat
    69241 atactaaatg taaagttgcc taaacatggg tcaagcttta aagaagattt attttaaact
    69301 ataaaatgat aaaaacttag cttaatagga tggagagatt ggaatgtttg aaaagatagc
    69361 acaaagtagt aaatttataa attctaaaag tgatataaaa cctaagattg gtttgatatt
    69421 aggttctgga ctaggtgatt tagcaaatga tatagaagac cctgtcgcaa ttaaatatag
    69481 tgaaattcca aacttccctg tatcaacagt agcaggacat gctggacaac ttgtaattgg
    69541 aaaacttgaa ggaaaagaag ttattgctat gcaaggtaga tttcattact atgaaggata
    69601 ttctcagaaa gaagctactt ttccagtaag ggttatgaaa gaattaggag tcgagattct
    69661 tatagtaact aacgctgctg gaggcgtaaa taaagaattt aaagcaggag atttgatgct
    69721 tataagagac catataaact ttagtggaag taatccatta gtaggaaaaa atgatgacag
    69781 atttggtgct agatttccag atatgtcaga tgcatattct tctaaatatg tagatgtagt
    69841 taaaaactgc gctaaagaat gcaatataga tgtcaaagaa ggcgtttata tgttttttag
    69901 tggtccaaac tatgaaacac cagcagaagt gagaatggca caaattttgg gagctgatgc
    69961 tgtaggtatg tctactgttc cagaagtcat agtagcttct cactctaata taggagttat
    70021 tggtatatct tgtataacaa atatggctgc tggcatctta aatcaaccac taagtcatga
    70081 ggaagtaata gaaactactc aaaaagttaa atcagaattt atgaatttag ttaaaacaac
    70141 ggttaaaaat ttataagtta aagcttatta tagatttttt gaggaagttt ataataaaat
    70201 agttaatgtt taatttgaaa agaattaata aaaagctgtc ttgatataga aagttatttc
    70261 taataaagga cagttttttt ataatactac aacatttgaa agtgttttaa agtttaatat
    70321 ttatttaaat tattataggt tagaatggag atttcaatta tgagaatgta tgatattata
    70381 aaaaaaaaga gagataacct agagcttagt aaaaaagaga taaactactt tatagaaaac
    70441 tattcaaagg gagatatacc tgactatcaa gcttctgcac tattaatgtc gatttattta
    70501 aataagatga ataaacagga aactgtacat cttacagaag caatgatgaa ctctggagac
    70561 atgataaacc tatctgagat agatggaata aaggtagata agcatagtac tggtggtgtt
    70621 ggagataaga ctaccatagc tcttatacct ttggttgctt catgtggagc accagttgca
    70681 aagatgtcag gtagaggtct tggtcatact ggtggtacta ttgataaatt ggagtctata
    70741 ccaggttttt cgacagaaat ggagataagt aaatttattg attctgtaaa taagtctaaa
    70801 atagcagttt gtggtcaaag tgcaaaggta gcaattgcag ataagaaaat atatgctctt
    70861 agagatgtta cagcaactgt tgataatata tcattgatat catcaagtgt aatgtctaag
    70921 aagttagctt caggagctga tgcaattgtg ctagatgtaa aaactggtga tggagcattt
    70981 atgaagacat tagaagagtc ttttgagtta gctaaatcta tggttgatat aggtactggt
    71041 atgaatagag atacaatagg gattgtaaca gatatggatg aacctttagg ttttgcagtg
    71101 ggaaactctt tagaagttat agaagcaatt gagacattaa aaggaaatgg acctaaagac
    71161 cttgttgagc tatgcgaagt attaggagca tatatgttgg ttttatcaaa ggtagcacat
    71221 gattttgaag atggtgttga aaaaataaga gaatcaataa aatctggtac tgctatacaa
    71281 aaactcaaag agtttataga gaatcaaggt ggtaataaag atgtagtaga tgattattct
    71341 ttattcaaaa aatcaaagta taaatatcca gttaaatcaa ctaaatcagg ttatataagc
    71401 aaaattaaag ctgaagatgt tggtgtatcg gctatgattc ttggagcagg tagagaaact
    71461 aaagatgata ttttagattt atcagcaggg ataattttag aaaagaaagt aggagattat
    71521 gtaaatgaag gtgaagtttt agcttacatg tattataatg atgaacaaaa gctttcattg
    71581 gcaaagggaa gatttattga ttcctactct attgtagatt caaaaataga aaaaaataaa
    71641 ttaatatatg gtattgtaac taaagaagag attaaaaagt tttagaaaat tttagaaaag
    71701 tgattataaa aggcctaaca tgtcaaaaat aatgttaggt tttttatttt ttgatagact
    71761 ataaattata ccaaaaatat atattttaaa acatttttta caatataaat aagtttattc
    71821 tacaagatga ttgaaaatta aagtatctag ttttataata gaaaatggat aaatatacat
    71881 aaggagtaga ttatattatg aactttaaag aaaatagatt gaaaatagca gtattaataa
    71941 ttgttatttt gattatctta gcaggtatat ttgtgtttat acaaataggt ccttatgata
    72001 aaaataacaa aaaagatgta attatcgacg ttccaagtgg agcatctgtt ggaaaaatat
    72061 ctgacatatt atatgaaaat aaattaataa agaatgaact attatttaaa cttttggtaa
    72121 aggttagcaa taaagctccg tctataaaat caggaacata cttacttaat caatcgtatt
    72181 caaacaatga tataataagt cttttagttt caggtaaaat atatcaggat ggtataaaag
    72241 tgactattcc agagggagct acatctaaag aaattatagc aatgttagta agtaaaaatt
    72301 taggagataa agctactttt gaaaatttaa taaaaaaacc tcaagaattt tatgataaat
    72361 ttccatattt gaaggaagat ggaataacct ctttagaagg gttcttgtat ccagaaactt
    72421 attattttaa ttcaaagaaa caatcagaag aagatatttt aagcgaaatg ttaaaagtat
    72481 ttgacagtaa atacacggac aagtttaaaa agaaacaaaa agaattaaat atgactcttc
    72541 aagaagtaat ggaaatggca tcaataattg agaaagaagc tgttcttgac aaagacagac
    72601 ctataatagc aagtgtgttt tataatagac ttaaggtagg tatgcctctt caatcagatg
    72661 ctacaataca atatatattt gaagagagaa agaaaattgt aacatatgat gatttaaaaa
    72721 ttgattcacc atataatagt tataaaaata agggattacc tcctacacca atatcaaatc
    72781 ctggtataaa atctattgaa gcagcattat atccagagaa aacagactat ttatattttg
    72841 tagctaagat tgatggtgga aataattata gtacaaacta tcaagaccat ttaaaatacg
    72901 ttaaagaata taaagaagca agggataaac aatcaaaaga tacaaaagca acaaataaag
    72961 aaaatacaaa aaaataaacc atgattataa aaagtctaac agggtaagaa taatgttggg
    73021 cttttttatt gaaaattgtt attcttagat ttataataaa gaaagtgtaa atatatataa
    73081 caatatgaat ttaaaaaata ataaattaat ataaaacttg aatatttatt attttaggga
    73141 gtgtttttat gagtaatata gttaatgatt tggttgaaga ttatataaga gtgacattaa
    73201 aagaaaaaga aggattttta aaagatttag aaatttatgc agaggaaaat agtgttccta
    73261 taatacataa agaagtttca gatttattaa aagtcttgtt aaaggttcaa aaaccaaaga
    73321 gaattttaga agtaggatgt gcaattggtt attcttctat tttttttgca actattatag
    73381 gaaaagatgc agatataata actgttgaga gaaatgaaaa aatgatagaa aaagcaaaag
    73441 aaaacataaa attagctgga tttgacaata acataactat actagaagga gatgcagaag
    73501 aaaaacttag tcaagtccaa ggtgaatttg accttatatt tatagatgca gccaaaggtc
    73561 aatataagct attttttgat ttagttatag ataaattaaa agatggggga cttttagtat
    73621 ctgataatat tttgtataaa ggtatggttg ctcatgatga ttttgttgta agaagaaaaa
    73681 agactatagt taaaagaatg agaaattatt tagattatat atgtaattgt gactatttaa
    73741 gcacatcatt ggtaccaata ggtgatggtg tagcactaag ttataaagaa agtaaaagag
    73801 gtgatgtaga tggaattaaa taaagtagaa cttttagctc cagctggtga tttggagaga
    73861 ttgaaaatag ctataacata tggagcagat gccgtttata taggtggaga aatttttgga
    73921 atgaggtctg cagcgaagaa ttttagtaag gaagatatgg cagagggagt agcttttgca
    73981 catgaaagag gcaagaaagt attcgtaaca gtaaatataa tacctcataa tgaagatttt
    74041 ctacaattag aagactattt gttggaacta gaagagatag gaatagatgc agttataata
    74101 gctgacccag gagtgcttag tgtcattaaa aaagtaattc cgaatatgga aatacattta
    74161 agtacacaag caaatacaac caattatcta agtgcaaact tctggtacga gcatggaata
    74221 aaaagagttg tagtggcaag agaattatct tttgatgaaa tatctgagat aagagcaaaa
    74281 acacctttag atatggatat agaagcgttt atgcatggtg ctatgtgtat ttcttattct
    74341 ggcagatgtt taataagcaa ctatatgact ggaagagatg caaacaaagg ttcttgtgct
    74401 caatcttgta gatggcaata tcatttggtg gaagaaaaaa gacctggtga gtattttcca
    74461 atatacgaag atgaaagggg tacattcttc tttaactcaa aagatttatg tatgatagag
    74521 tatataccag agttaatcaa atctggtata acaagtttaa aaatagaagg tagaatgaag
    74581 actgcatact atgtagctac tgttgtaaga gcatacagaa tggcaataga tgaattttac
    74641 agagacccag aaaactggaa gttcaatcca atgtggatgg aagaactaaa aaaaggtagt
    74701 catagacatt ttacatcagg tttttacttg aataaaccaa caacagaaga ccaaaattat
    74761 caatcagcat catatgttag aaactatgat tttataggta tagttagaga aacagaagat
    74821 gaagatggtc ttattgttgt tgagcaaaga aataaaatgt gtgttggtga tgaaatagaa
    74881 gttatgggac catataaaga aactatgttt actaaaattg aagaaatgta caatgaagaa
    74941 ggagaagcta tagaatcagc tcctcatcct agacaaatag tgaagttaaa gctatcagta
    75001 aaagttggta aagattatat gcttagaaaa gttatagaag aaaaggttga agaataataa
    75061 aaaattgata aaaatagtat tagcccctta gaaattgtca ataatgaaat tatctaaggg
    75121 gtgatttcat gtcaaaaaag aagactccat ttttgaaaaa agtgggaaag agaagctggt
    75181 gtatatttac tataatttta ataatttata gtgttttaat ttataggcta gttgatatac
    75241 aagtattaaa aggtgataaa tacaaacaaa gtgttgaatc acaaagcgtt gagaaagtcg
    75301 agttaaatag tggaagagga ataatctatg atagaaacaa caagaagctt acagatacaa
    75361 gtaaatctca ggtattaatt gttgaaaaag aaaaattaaa taataactat aaaattttgg
    75421 agcttattaa gaaagctact aagatgaatg atttagatat atataaagct gtacaagagc
    75481 aattgacacg ccctataata cagattcaga ctaaaaatat cgataagagt atgaaaaaag
    75541 aacttgagaa aaatggaata atggtagaag aaaaaactat gaggtacgca aaagatggtt
    75601 tattatcaca tacaatagga tatataaaag aagatgataa atcaggtcaa tcaggaattg
    75661 aaaagagtat ggatagtgta cttagaaatt caaatgaaaa gtatataagt gcttttaaag
    75721 ctggagatgc aggaaatgaa aaatctctaa acatactaaa gggaagtgta aaaactgttg
    75781 ataataagga taaagataga catctaaaaa ctactattga ttataacatt caaaaaaaat
    75841 tagaacaaat actaaataaa gaagaaaatc ctacagcagc aataatctcg gaagcatcta
    75901 caggtgaaat tcttgcaatg tgctctagac ctaattttga ccaaaatgac atatcaaaaa
    75961 gtttaaaagg aaaaaatgga gaatttgaaa atagagttat aaaagcgaca tatccaccag
    76021 ggtctgtatt taagatggta gttttatttt ctgcacttga aaatggtgtt atagatgaga
    76081 actatactta caactgtaca ggtaagacta aagttgggaa tactaatgaa atactgcgat
    76141 gtaataaaag agatggtcat ggtttccaaa acttaagaca agctttttct aattcatgca
    76201 atcctgcatt tttagatata gctatgaaac ttggaaaaga aaagatactc aaatctgctg
    76261 aaaaattaca tttatttgaa aaggttgata ttggtcttga tgaagaaaaa attagagaag
    76321 ctccaaaaaa catatcaata agaaatttag ctataggtca agaaaatata gaatttacac
    76381 cacttcaaat aaatcaaatg actcaaataa tagctaataa tggaacattc aaaccactat
    76441 acttatataa aagtcttgtg gacaataata tgaatacaat aaaaacttat aagtcttcaa
    76501 aaaaagaaga acttatttct ccttatgtgt gtacacaagt taaagaatat atgaagtctg
    76561 tatctaggat tggtacagct aaagacctaa aagatattga aggtggttgt ggagttaaaa
    76621 ctggtacagc tcaaagtagt ttaaataaaa aagctataga ccatggatgg ataacaggat
    76681 tttatcctga agaaagacct aagtatgtaa taactgtgtt agtagaagga actcaaaaag
    76741 gaaataaatc tgcaacacct atatttaagg aaatatgtga aagtataaaa taaattatgt
    76801 actataaaat ttaaggatat atcgtaactt tgattttaga tagaaaattt tgtctaatga
    76861 tgtacgatat atccttttaa aatatagtat taactttctt gaacaagctc tttttctagt
    76921 tttttaagag cttttttttc gattctagat acatatgacc ttgatatatc gagtttttgt
    76981 gcaatttctc tttgtgtctt atagccataa ggagttaacc catatcttaa ctggacaatt
    77041 tctctttctc taggagtaag aattttgttt agttgttcgt aaagttttcc aacttgaact
    77101 tttagttcaa cttcatcaag aacatagtta gcctctgtac caagtatatc taaaagactt
    77161 atttcattac acactactct ttatatgtta ttggtattac tggtcttcat gtaatttcaa
    77221 atggaccatt aattcaaaag aatctagttt ttgttcttta gacttataat aaactgcttt
    77281 atcaattaca gattttagga gtttattttt tccaagggaa tctgaatcat ggtaaagtga
    77341 taacacagtt ttaatatctt ctattatttt agaattgtct tttttaacag tacttaatct
    77401 attttttact gtcttaattg aatctttaat ttcttcagtt cttgaactta tattgttgga
    77461 cctttcaata aatgtatctt catcatatat tcctcgttct agtaaatcat ataacttatt
    77521 tttttgcttg cctaattctt ttaattcagt ttctaagccc tttaagactc gtttttgaaa
    77581 ttctatatta ctatctttat tatttttatc taagtctata tcagatgctt ttaattgata
    77641 tttttttaca gtgtcttcta aagattttaa aatggcagct tcaataaatt caaatcgaga
    77701 acttttattg caaccaggat gataacaaat tatatagtcg tggtctgcat atggtctata
    77761 tactaatggt ctaccacaat ttttgcaaat cactattcct gcaagtggat tttttatttg
    77821 attaccatag ctgacatgac catttttttt gagtatattt tgagcttttt tccatgttat
    77881 ttcacttatt aaaggttcat gctttccttt tgcctcaatc cattcatctt taggtcttag
    77941 tttaactgtt tttattttat ttggattttt agattttttg tagtcctttt tttgccactg
    78001 aatgtagcca caatatacct tattttttat tatatttgta attgcagaat tgtaccaatt
    78061 agcacctgta gcagttttaa tgcctaagtt atttaggtat tttgatattt tactacaacc
    78121 catatcttca ttaatatata agtcaaagat agtcctaact acatcagcat ccttatttgg
    78181 tacaagtatt ctttcttttc taccagttgt tacagcatca tatccaaatg gagcagaggt
    78241 tcctatgaaa ttcccttctt caactgattt tattctacct ctttgcatcc ttcttgatat
    78301 aagttttaat tcttttcttg ccataaatgc ttcaaattct gaatactcct catcaaattc
    78361 atctgttagg tcgtatgttt ttctaggtgt gataattttg gtcttacttt ctttgaatgt
    78421 ttctaatatg ataccttggt ctttcatgtc tccacgacca agtctgtcta agtccattac
    78481 taagactgca tcatatttat tttcttcaac ttcttttaga agttcaagca ttttgggtct
    78541 atgtattata ctttcaccag aaactaattc ttcttttatc tcaattacat ctaagttttg
    78601 ttcttttgct agttttagta gggttgattt atgtctactt aaagtttcaa attcgccttg
    78661 tttttctgcc tcttcatcag cacgggattt tcttaagtat atggcaacac tcataataag
    78721 taatcacact ccttatgcac tattatatag taaatcaata gagtttaaaa tatagaaaat
    78781 aagcatgtca aaagttaatt taactttcaa catacttatt ttctataata ttaatgcctt
    78841 ataatccttt aatatcattt agattagttt ttgcatattc attatccggg ttaagttcaa
    78901 gcgccttatt gtaagattct ctagctttat taaattctga tttactcata aaaataacac
    78961 ctcttaaatt gtaagcatca ctagcgtcta ttttataagc ttcattattt ttatctagat
    79021 attctaagta tttatcaatt gactttaaag cctcatcata tcgttgtaac tctatataaa
    79081 tatatgattg tgtataatat gcaagtggat ttttatcatc aatttctata gcttttttga
    79141 tatcaatagc agctttatta taatccttat cttcatcttt ttctgtttct gacctagcga
    79201 ttttgacata attagagcta agagctcttt taaagtcttt atgccataat aatttatatt
    79261 cattatcttc gattataaaa tatctatcaa aatttgcagt atcttcttta ttttcagtga
    79321 tatactttat agtatcagtt tcttttattt taacaagatt tgtgtactct ttattagaat
    79381 atttgtattt ctctacttta ttttcttcac caagtttata atcttttagg gtttgaagtt
    79441 taaataaagt atcttgatat tcttcaaatt tttctagact gacgctttcc ttactgtctt
    79501 tacttaataa attatatgct acttcgtagt ctttgatttt tatactatca aggtactttt
    79561 tagctacttc tgtagcactt tcttttggag cacatccaac cattgatatc ataattaaaa
    79621 atgatactaa tattgctgtt atttttttac tgattatcat aatataatcc cccttatatt
    79681 gtctctcatt aattttattt tatcaccata ttctaccaaa gtcattaatt taggagtgat
    79741 atttttcatt aatattatat taagtaataa taacttttta aatttatggt aacattttcc
    79801 tgaaaagtat tatataattt aggtgaaaat atttaagaga aggagatatt atgaaaatta
    79861 aaaaattatt aacaataggg ttatctttat ctatatttat tgctagttgc cctatatctg
    79921 caaatgctct tgataaaatt gaatcaatta aaggtgcaga taaatacgaa actgctggta
    79981 taattgcaga caaacaaaac tatactacag ctatattaat taatgcagac agtacaatgt
    80041 ctgatggatt aagtgcaagt ggacttgcag gagctataaa cgctccaatt cttttgacta
    80101 agaaaaataa cataccaaat gctacactta aaagattaga aaaggcaaaa aaagtatata
    80161 taattggagg agaaaactct attgataaat atactgaaac tgttctaaaa ggcaaaggaa
    80221 tagagattaa aagacttcaa ggtagtgata gaattaagac aagctataat gtcgcaaaag
    80281 aaataaactc aattaacaaa gtaaataaag tcatattgac taatgcattt aaaggagagc
    80341 ctgatgcaat gagtgttgca cctgtagcag ttagagataa agcagctata gtattaactg
    80401 atggaaaaag tgttccattt aatacaactg gtgtagaaag ttatgtaata ggtggtactt
    80461 catcaatgaa tgacaaaata gttaaggata ctaattcaac tagattaggt gggacagata
    80521 gatatgatac taacaaaaag ataataaata aattttatag tggagtaaaa gaattttata
    80581 tagcaagtgg tactgattta gtgtatgctc ttgttggttc tactgctgct aaaaataatg
    80641 ctattgtgtt agttgataat gatagtaata aaagtgtatt gaaaagtaca actaaattaa
    80701 ctgctatagg aaatttgagt gatagtatat tacagcagtg tttaaatgta acaaaaaata
    80761 taggcgattc taatactgga agagaatata cagtagaaga tgctgctaat gcagtgaaaa
    80821 aactattagg tgtgaagaaa ttttattaca aacctaatta ttcagaagat gaagatttaa
    80881 tatttctact agataaaaat tttgattttt caggaaaaga gtactatgta tttgcttaca
    80941 ttaaacaggg tgcagagggt gatgttagat actgtgtagc taaaaatgat atgagcaaag
    81001 tttatacata tgatgttaat ggtaatatga aagtatgtaa tccagatgat tataaaaata
    81061 aaggaagtat aacagaggaa caagcaaaac agatagcatt gaaagaatgt gctaagagac
    81121 ataaagtcag tatcaataac ttagtagttg atatgataga ttttagagat gatatatata
    81181 gtggaaatgt ctatgctgtt aaaatcaatt caaaaaatag taatggtact tttggttggt
    81241 tttttataga tatagaaact gggaaagttt ataattaaaa ttagaacttt taaacaagtg
    81301 tttttaatta tataatttac cataatatgt tataatattt ttagcaagaa gatttaactt
    81361 acaatctata gagtggagtt catgtacaaa agattatcct cccaacgatt cgaagggagg
    81421 tgagttcatg gataactttt tgtttaatgt tttagctagt ttaacagcta gtgtggtagt
    81481 ttacttaatc agtaaactat tcaaaaaagc aaaaagccac tctcgcacaa agagtgactt
    81541 acgagttgaa tttaaattta tatttaaatc caaaaaataa actctgttta tgatgaactc
    81601 cactctaacg caaaatagat tgtagttctt cttgctttta ttataccaca aaacattata
    81661 aataaaactg ttgtttataa aaaaatgcaa agtaaaattt tttataaaca atgataaaaa
    81721 ttttattata gagctattaa cttattaaat atctgtaaat gagcagatat ttcataagtt
    81781 aatatttatt gtttacataa aatatttggt aaaaataagt aagttttata tgttataata
    81841 gttgtagcaa gaataataat cgaaagcagc aagcatgtca gctggtgtta tatcagttta
    81901 tatttatgat aaaataaaaa tctcccaaac gccaataaga atgattcaaa aaaataatat
    81961 tttcacttaa aaataatcac tctttatagg agtaaattat tttcttgatt ttattatact
    82021 acaaattggt acagatattt aaaaataata tattcataat attataaata gttttgcagt
    82081 gagcgatatt tttgataaaa tagggcttaa cagttgaaac ataaggcatt gagggtatat
    82141 gataaatatt atcatttgca ctactcgtgg ttcactgcaa atttgagaga attgtataga
    82201 tgtaagtctt ggaaatgctc aatttatttt ggggttttat attaactaag tggtatgtaa
    82261 agtgttcccc tctaagctct gtatatatat attccgtttg ttttatatta actaagtggt
    82321 atgtaaagaa gtgttgatat ttatattgtc tatccccgct agcttgtttt atattaacta
    82381 agtggtatgt aaagtcgtaa attacgaccg tacctttcgt aaaataacaa tcgttttata
    82441 ttaactaagt ggtatgtaaa gctttttgag tatgagtaca agcataggaa aattaatagt
    82501 tttatattaa ctaagtggta tgtaaagaac aaaaaagata catctgtaac taatttttat
    82561 actgttttat atcaattaag tggtatgtaa agacagatat aatatcaaaa taaggttagg
    82621 acttttaaaa gcatagccat atcagtaaaa atttaattat catttaaaaa ataaattttt
    82681 atttaaagaa tacacataaa tatttccaga ctcaactctc ttaaactatt ttcatatctt
    82741 ttagtagata cctttgttgt tttttaatct ttagcaactt gttcttgagt gaacctctta
    82801 ttttttctaa gttatttcaa gcttttcaaa aaattctcta tttatattca tcacacatat
    82861 aatacaatta attcagcttt aattgccaat atttagtttt tctgtatctg ataaaccaag
    82921 aatataatca gtatataaac caaaaatttt agcaaatatt attaacccat cgtctcttgt
    82981 tggtctttca ccagactcta ttctattcat aacacttgta tttatatttg ttttttcaag
    83041 caattctttt tgagaactat tcatattttc cctaatatat ttaatccttt gatttacatc
    83101 catacataat tatctcgaaa agtttctgtt ttggaaatat tgttattgaa atatagcaat
    83161 taatgtgaat atatgaaaaa gatacactat gattttataa aaaagaagac atacataaaa
    83221 tttatactta caaagtgttg caaatgagtt aggttttaaa aatgcatcaa tttattttaa
    83281 gtacaggaaa ggggaatatt caattagagt tgatatgtta cctataaact atctaagata
    83341 cttgattatg atatagaaaa tttttttaca aattaaattt ctaagataga aatttaatta
    83401 agaggatgat gaggatgaat aatttacaag taatataaag aaataataag agaattttaa
    83461 atgcatagca actagcagat atatatgaaa atgatgtaaa caatatataa actaacttca
    83521 atagaaataa agagaatgta aattatgttt tattacaatt cgagtatttg aaagaattta
    83581 agaactaatc tattaatagt cagttgattt caaaacattc tagtcaatta tacctttgga
    83641 tcgaaagatg tgcaaataga cactgcaaaa tattagatat tgataaaact tgggaacaat
    83701 ttgacaattt agagaaaata tatttcaaga ttaagcgaga gaaactaagc tgtatagaag
    83761 atgtattaat agaaaattta agatttaagg atacaaatta ataaagcaat aatatggcat
    83821 tagatgtaaa aatagaagtt aaaataataa aagatgttgt tatattaaat ataacacatt
    83881 ggaaaaaaga aacaagtcta ttaacagtta aaatagctag aagtcaaggt gatttaagtt
    83941 atgtaaaata ttttgctaat gagagctaag agcttcttaa caagagtttt ggtgtgtctc
    84001 ttgaaacaag gttaacaatt aataaaagac gaatggcaga agaaggcgta tgtaagttta
    84061 aaagagataa gttaaacaaa ctagatacta tgtaagagga taagaaactt atagaagaat
    84121 atgttacttt tgtaaaggat ttagctttaa aatatagaat ataaagtgat tttaagtaaa
    84181 aattgtaaca attaaataag tataagacaa gtttatgagt tcatatttta taacaagggg
    84241 tgatgttatg aaaatactac aacaatttaa accatacaaa tatgataaag aaaaaaatat
    84301 agaatatgat gaaaaaatta tagctaatca aaacacagaa gtttatatag tatatccacg
    84361 tatatctgat gaagaaaata ggagaagatg ggaagagttc aatgaagtag ctaaagaagt
    84421 agctattaat atagctatga agaaagttga gacagtagaa agttaagaga atagagaagt
    84481 tgctaatact tagcactttc tcatagaaga aaattggaca actattttta aataattagg
    84541 aataaaaaag ttaaatcata tttgaaaaaa ggcgataaaa ttgttgagta ttgttattag
    84601 taataagaat atattaacta tgtattaaaa gaaattataa gtttttagta aatatagtat
    84661 ttaaggatat taaaactggt aaaaaatatc atttagacta ttaaataaaa aagtgctggt
    84721 caaagtagca acacaataaa taaaaaaact tatagaaatt ataagataaa aagatgagat
    84781 ttgaaatggt cgaagttaat ataaaaatta aaggtgaagt aagtgaaata attaactcaa
    84841 ttagaggtat atttaatagc tttgatgaag aattaatatt agatataaaa tcagagtaag
    84901 aatataaagg tagatacgta gaaagttata agtaattcaa gacttaaatt aatttctagt
    84961 ttttttaatg caaaaattta ataaatttca aaatataata attctgacat ctaaaaagag
    85021 ctattaaaaa tgaataatat tgactattaa gatatgaata gtgtacatat attaaattaa
    85081 gatatcaagt aggttaattt tatataatga tggggctcaa attgaagagg cgatataaaa
    85141 atgtattaat atatataaat ataagaacta taatacatat taactgtaaa attaagttta
    85201 tagagttata tttaacattt aatgaactga aaaataaatt agcaaataat gaaaaaacaa
    85261 cagtaataaa tgagaataac aaagtatttt caggattagt ggatttttct aattgagctt
    85321 taatcctagt ttgttcaatt tcgatatttc taatattatc aatttatttg taataattat
    85381 caatttttgc gaaatatttt tgataattta tagaacttta tatattttcc ttgaagtatt
    85441 tttcgccctt attgtttggt ttccaatttt aaaactcata aactcccaat aaattcatgt
    85501 ataatatacc ttaatttata atatatttaa gagtttattt cagtaatttt tcgaacgatt
    85561 ttgatatatt tcatttatag ttttcaaaaa cttatacaaa aaagagtgtt tcatctttct
    85621 aaacactctt tttataagaa tttgaataat aattttttaa aaattgataa tatggttatt
    85681 tctttttcaa gtttatagtt tcctcatttc cattccaaga tataattagc ttgtaactag
    85741 attctctatt tgaataaaga cctggtcttt gtatttttat tgctttttct tgacctgctt
    85801 ctaaaatttc attttttaca actacaactg catcttcacc atctataaat tgataggaat
    85861 aattaaattt ttgttcaact acatctttac tatttttata ttttatttct aattttgagt
    85921 gtccttcagt agttacaaat ttagctttcc aattttctga ttctccaata aagacatttt
    85981 tatcattttt tatattaagt atagctatca cagagattat taaaactata agaataccta
    86041 taaaaaattt tttcctcata tcaatccctc ctttgaataa ttataacatg agaatagtta
    86101 ttcaatacta attttaaaaa tattgtggat ttatattcta ttacaataga atgtctgtta
    86161 taacaaataa aaagtaagga ttaatatgaa ttataggtta aaaaaatctg taacaactat
    86221 tttatcttta ctcataatga caatactatt accaacaaat gcaagtgcta gtaaggtaga
    86281 agattcatct atgaaagtaa tgtattcaga gaaacaagta acagacatgg acaaattata
    86341 cgatatggct aaaaatggaa ttactgatgt taaaagttcc aatgaaaaag gtataatcaa
    86401 aaatgcaaga acaggagagt ccatatacgt tgattctata tcaacaactc aattattaga
    86461 agttaaacaa tctaaaaatt taacatcaaa gatatattct aagacagttt ttttgatact
    86521 aatacaataa agcctcttag aaaagcaagt atatcagaag atggatggga taaaactggt
    86581 ggtgtaaaag catctggtac agttacatat acaatatcaa aaggagatgg agcatttcaa
    86641 tatatttccg ttagtaaagt ttctggaaac tggtctattg cagacggcca gattcgtgta
    86701 acaaatagaa gggtgcatat aaatcaaact ggatttattt ctaatgagct aggaattaag
    86761 cagcaacaaa agaaagagcc aacatcaaat tctttctcat ataatgcacc ttctagttgg
    86821 aaaccagtag gtagagattc agttcaatac aattgtgggt ttgaattaat tgcaacatta
    86881 gtaagaggag gaagttcttg ggcattcaat ttcattgttc aaccttaaaa tattttaagt
    86941 gaattttatt aaaatcaaag atatacatat actttaaaat tagagaatgt aaattaattt
    87001 gtgtttttaa agataattcc tatgttatag taacaattgc ttatttacta ttaatatttc
    87061 ttaatatatg aattttattt taataaatta taaaaaatgt atattgggat gtttttaaat
    87121 atttttggaa attatatata ttataacaat tatagcaaat ttttagggta taatttttaa
    87181 aattatattc tactatcaaa agatatgaat aaatgattgt atatattata tcaattttta
    87241 tatttcatag tccatttttt catcacattt tcgcttgtca agaataatat ctttaagagt
    87301 gaagcgtttg atgtaaatct ggactttgtt tttgagacat ttttgaaata tttattaaat
    87361 ctttcgatta tacttgtaat atatattata gatattactt attttagtaa aactaaagga
    87421 tgatgctaca acattccagt tatttcccaa aattttaatt tctgaagtat actgtttaca
    87481 ttatttttaa tctattttat ctaaagtcga taaggcttct tattcattaa ctgacctata
    87541 tacagattta aaattactta ttaattcttt tgagtccttg tatgaaacat atttaaagta
    87601 tttcttatct aatgtattaa acatttttgt attacagaat gaggataact tgtagctatt
    87661 gtctctttga aataagtcat ctgtgtttac tcctaaaact acttatatct gtagatttta
    87721 taagttctcc atcttatata atttctttga ttaattgttt tcttaaatta ttcataaaaa
    87781 aatctccgtt acaatatttg attatattta aatcattgct ataaagaaga cttttattaa
    87841 ctttgaaaaa caaattattt taattgctgg tgattagttg ctaccttctt ttgatattaa
    87901 ttctattaga ttttatatag ttatatatct ctttctaact aagtaatata atattactgt
    87961 tatagtagct actaatatta ttgctattat tgtaatatct aatctttttg taaataatcc
    88021 tattgctata tattcaaaac ctgttacata tcgataaagt acttctagtt taatagttct
    88081 ttttctatct atatttccat attttgattc taatttatta aaatattttt cattacaaaa
    88141 accaatttta atttcaatta aagatattat tgtagttaat attataattc ccaatcccat
    88201 aagtataaga taaatgttcc taaaattcat agaagatacc tcctttataa tataatcatc
    88261 aactcatgtt gtattaattt tcctaatcaa agtataacag taacacaagt ataaagagta
    88321 tctaaaatat tacaaatatt aaatgagaaa aagatggtaa gttaacccca ccatcttatt
    88381 ttttatctac taatgaatga tgctacaaaa gttagtataa aaaatgaaac aaacaatata
    88441 atgaacttgt gtaatttact tagttggaat gctttattac aaaataataa aattaatgct
    88501 gaaacaattg caaaaagtag atattttata atcattttat cacctattga tttctacaga
    88561 ttgtaagtag tatttggtta cacaagcacc tcctttatta taacgtattt tttaaattta
    88621 aagatttttc cagatgttat atttgactca aggtacattg taattaatct aactataagt
    88681 ggcaagtact gtcctatacc aggaatagca ccagccaaaa gtcctgaaat ccctatacca
    88741 gcatcagtta aagttaatgc aactccttta gaaagatata aattaaaacc tattctagcc
    88801 caaactattt tatttatttc agcttttcta taatataatt caagtagtgt caatatcgtt
    88861 cttcttaagg tttttaa
//
LOCUS       DAEQCW010000004        79948 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.004, whole genome shotgun sequence.
ACCESSION   DAEQCW010000004 DAEQCW010000000
VERSION     DAEQCW010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 79948)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 79948)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..79948
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.004"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            210..1031
                     /locus_tag="KRO40_000255"
     CDS             210..1031
                     /locus_tag="KRO40_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH2091099.1"
                     /translation="MGYKLIVTDMDGTLLGNNHKVTDENKTALQKVIKSGINVTLATG
                     RAFDSAKCNVDFLKEDMPIIACNGSLIREQNGNIIYSNKIDTRTCLNILDVLDKYDIY
                     YQCNSIDSMLSKKIEGREDRLSVFLGSETEVIVKDDLREEIFKKDILKFVIIEEKNPS
                     ILDEIRKELRKVQGIKITSSWPNNIEVMNEGVDKGNAVKILAEKMNIDREDIIAFGDN
                     YNDIEMIKFAGLGVAMGNAEELIKQEADYVTDTNQDSGVAKAIYKFLELKESLSS"
     misc_binding    1110..1321
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1408..2724
                     /gene="argH"
                     /locus_tag="KRO40_000256"
     CDS             1408..2724
                     /gene="argH"
                     /locus_tag="KRO40_000256"
                     /EC_number="4.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HBH2091100.1"
                     /translation="MKLWGGRFRKAENQLMEEFNKSFGYDCVLYKKDIEGSVAHVHMQ
                     VKCGLLTEEEGKSITEGLKGILEDVENGKLVLDGEYEDIHSFTEINLIQRIGDVGKKL
                     HTARSRNDQVAVDMRLYAKEKANDLVGLISEFKATIKDVADKNPVMMPGYTHLQRAQV
                     VTFKHHLMAYYSMFDRDEKRIKNAIEILDESPLGCGALAGTTHDIDRSITCEQLGFKK
                     VVDNFMDGVSDRDYLLELMSDFSIIMMHLSRLSEELILWSSQEFGFVEIDDLYTTGSS
                     IMPQKKNPDGAELIRGKTGRVYGNLFGLFTVMKGIPLAYNKDMQEDKEGFFDSVHTLE
                     MCIQIMDRMIATLKVNEDKMKQAVKNGFLNATEVADYLVKNNVAFRDAHGIVGSIVIY
                     CEDNKKAIEDLTLEELQKFSDAFKEDIYDFIDYESILNKGIKKNLK"
     gene            2973..3311
                     /locus_tag="KRO40_000257"
     CDS             2973..3311
                     /locus_tag="KRO40_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2325 domain-containing protein"
                     /protein_id="HBH2091101.1"
                     /translation="MNLLVIGGHERMEKDYMVMAKKKGYKTKVYTTMSSKLNNSIGRP
                     DAVVILTSTVSHKMSRTVESQAKKQDILIVRHKNSSKVAFNECLDMVDECLGNCSKCK
                     LKDKQKQKNI"
     gene            complement(3438..4727)
                     /locus_tag="KRO40_000258"
     CDS             complement(3438..4727)
                     /locus_tag="KRO40_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH2091102.1"
                     /translation="MKRNLSLLLICLLIFTSFLGSSNISFADNEPAIVAKHAVLMDYE
                     SGKILYNKDGNSKLYPASTTKVWTACLVLKEVKDLNQVIEIKDLPQIDGSSMYLKNGE
                     SFTVKQLLDALLVHSANDAAFVLARYVGGGNVQKFIDLMNSEAKKIGATNTHFNNPHG
                     LPDPNHYTTAHDMALIAREAMNNDTFRQIVKTKSLKFEATKAYPYERYFVNTNKFLTS
                     HDKITYKGQPINIKYDIVDGIKTGYTDAAGKCLLSSAVKDGRRVIVAVFNSTNADLYL
                     DSRILIDYGFDNFKCATIVDKEKYTDTKKVLFTKQHELIYEPKNSYRIFLEKDESQGN
                     YDTKTELNKIDLPIKKGAKVGTLNVYNNGKLENSIDLIAKNNLDSSLPFLTENNVLMT
                     FVKIIAGILVLLVLFIIASNIKKKKRKKARSKKNMKK"
     gene            4807..5511
                     /locus_tag="KRO40_000259"
     CDS             4807..5511
                     /locus_tag="KRO40_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HBH2091103.1"
                     /translation="MKKKVKFISFFVLFILIISSIIVYKSLIFKDDIYVVSKKNLPNE
                     KTHVVENEIKGEDNNHSKVTKDIDKNFQNNKITIYISGAVNRPGIVTIESDKRLYDAV
                     ELLGGTTKEADLNGVNLSVRLEDEQHYIIPKIGEATSVTSNDDSNKPNQKNESRGEPK
                     NKSNKNISNESKVNINVATIEELDSLPGVGEATANKILQHREENGQFSSIEEIKNVNG
                     IGDKKYENIKDLICVD"
     gene            5603..6649
                     /gene="selD"
                     /locus_tag="KRO40_000260"
     CDS             5603..6649
                     /gene="selD"
                     /locus_tag="KRO40_000260"
                     /EC_number="2.7.9.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:5651..5653,aa:Sec)
                     /transl_table=11
                     /product="selenide, water dikinase SelD"
                     /protein_id="HBH2091104.1"
                     /translation="MKKEQKKLTEMTTAGGUAAKIGPEVLASVLSQLPKNDNIENLLV
                     GLDTADDAAVYKLNDDMALIQTLDFFTPMVDDPYVFGQIAASNSLSDVYAMGGKPLVA
                     MNIVCFPSCHDMDVLAEILKGGFDKVKESGALLVGGHTVDDKEPKYGLSVSGIVSPNK
                     VLSNATAKPGDKLIITKPIGVGVLNTAMKEGMVEQHIADKVIEIMIHLNKYAAMSFEK
                     FDVNSVTDITGFGLLGHTLEMAKASEVSIEIESKHVPIIEGAIEMAQMGIIPAGMYKN
                     MHYVSKDVEVVGNIEVAVQDILYDPQTSGGLLISVKEELAEELVKDMKLNGAIEAKII
                     GSVVPKGEKYITVL"
     gene            6667..8079
                     /locus_tag="KRO40_000261"
     CDS             6667..8079
                     /locus_tag="KRO40_000261"
                     /EC_number="2.9.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-seryl-tRNA(Sec) selenium transferase"
                     /protein_id="HBH2091105.1"
                     /translation="MIVLSKRELFAMLPSVDEVLSDNRIVEIINEYPRSLVLESVREV
                     IDLKRQFILRLKEDASNSVTIEFGEIIESAIERVKLNYSLSLKKVINATGTVIHTNLG
                     RSLLSEDIKDELWCAASRYSNLEYDLDNGERGSRYSHLTSTIKRLTGAEDVLVVNNNA
                     AAVLLVLSTMAKGGEAIVSRGELVEVGGSFRIPSIMALSGAELVEVGSTNKTHLKDYK
                     EAITEDTNVLMKVHTSNYRIMGFTESVSIEELVNLGKKYKLPVIEDLGSGVFIDLSKY
                     GLSYEPTVLDSIRQGADVVTFSGDKMLGGPQAGIIVGKKEYIEKMKKNQLTRALRVDK
                     LTICALEATLRMYLDETKAIENIPTLKMLTYKIEELEVKANKLFEKITALNLNANINI
                     EDGFSQVGGGSMPLETISTKVISITPEHMNVSSLEKKLRLSEAHIIARVYDNKYVLDV
                     RTIFDDEFDVIVEELRKAFN"
     gene            8193..10076
                     /gene="selB"
                     /locus_tag="KRO40_000262"
     CDS             8193..10076
                     /gene="selB"
                     /locus_tag="KRO40_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenocysteine-specific translation elongation
                     factor"
                     /protein_id="HBH2091106.1"
                     /translation="MKNVVIGTAGHIDHGKTTLIKALTGRETDTLDEEKKRGISINLG
                     FTYFDLPNNRRAGIVDVPGHEKFIKNMLAGASGIDIVLLVVAADEGVMPQTVEHLDIL
                     SFLNIKNGIVVLTKSDTVDDEFRELVKEDICEKIKGTFLEDAEIIEVDSISKRGIDTL
                     IEKIDKMSDDIEDKNENSPARLNIDRVFSIKGFGTVITGTLIEGKISIEDDLVIYPQV
                     LKTKIRSIQVHGENKDTAYAGQRTAINISNVKVDDIKRGDVLAAPNSLEESMMLDVKL
                     SLVNHLDKGLKHWDRLRLYHGTREILCRAVPLDKELIESGESGYVQLRLEESIVSKKG
                     DTFVVRRYSPMETIGGGVIIDPSPKKHKKFDEKVIEALKIKEKGELKDIIEEYLKRNL
                     KNYPNIKEIMSYSGAHEEDVKRALETLISEDKVFIIGNMYMHINQYNKLKENTIKLLS
                     EYHKKYRLRKGILKEEVRSKIESNFKTREMDILLEKLSTENAIKIENNIVSLLDFEVI
                     LNDKQKEIAKKIEKRLKSCGVSSILTIDEVSEGNHNYAEVLESMIGNKVEKLDDLYIM
                     DKDIYENAKNILINYIKENKEITLGEYRDLIDSSRKNCMIILENFDRNKITKRVENKR
                     ILF"
     gene            10181..12919
                     /locus_tag="KRO40_000263"
     CDS             10181..12919
                     /locus_tag="KRO40_000263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation-associated two-component system
                     sensor histidine kinase"
                     /protein_id="HBH2091107.1"
                     /translation="MKNIIPDVKPDIKEREDMSLLFIIMGSVLLLFIIKDIEKYETLL
                     HAIYTIFLVATGVIIFNTTKFKVDSFSTFLGLIFIATGVLECIYLFNSLGIKTKSIME
                     INITISAITDLFPILGVYLSFKFVKDNKQIYSSVILFIATATLTITSLFIISGICDYL
                     GNGKSQYALGVIISIFIIIISIVSGIELNSSSNKGKWEYDEKKIFNRIIVIIILSRVP
                     NLLHIVIDNRNVERILSQIIINVALYYLYNYIVSKNIKKTALELHDTNEELTKKTESL
                     KEKNKKLIYETEKIEELKGILMKRESRLQSTLDVAVNSIVVFSKDGEITYANKSFRNT
                     FGDYKEQDKLTDKIKNFNDLIESIHYVFVHEKNAEKLISTSDNKVYQAIFAPLIIASQ
                     TEGVLCVLEDKTKKKEYERKLIEANKRSKDFLESIGDGIVVLEGNNKIYVNNACREIF
                     KNNLESIDFSLVCKSEESIEKRYVIDGEVKYVEMSFSQYTNAGTNKTIIVIRDTTSRK
                     ISQIKLEESQSSYSRFIDILPDGICLLKEDLSINYANKSFLDMLAFTNIDDIKDSNIK
                     LLMNANTEEKMKFTDNMAKVLNENRSILLLEYELINSYDDIVEVELSALPFAIYNTRY
                     IMLIIKDLVHKKYSEQAEKELLERFKTDKIKTEFFANMSHELKTPLNVISSSNQLVDS
                     FYRNEKIKDYNNNIKSHVDLVRQSSYRLQRLINNIIDLTKMESGFYTLKLAKYNIVSV
                     IEDLFMNIEEYALRKDIKILFDTDLEEINVYIDKVEIERIMLNLLSNCIKFTDNGGWI
                     YVSIHYKIDKVIISVKDTGVGIPQDKLELIFEEFSQVDKTLSRNTEGSGIGLAIVKNL
                     VSLHGGDIEVVSEVNKGTEFLISLPMKGFSSEHYTEDKRIYNIQEKIKIEFSDIYY"
     gene            complement(13038..13982)
                     /gene="manA"
                     /locus_tag="KRO40_000264"
     CDS             complement(13038..13982)
                     /gene="manA"
                     /locus_tag="KRO40_000264"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HBH2091108.1"
                     /translation="MEPLFLKPIFMDRIWGGTALKDKFNYEIDSPTTGECWAISSHKN
                     GDCLIENGKYKGKKLSELWNKNRELFGNTPGDKFPLLTKILDANDNLSVQVHPNDEYA
                     KKNENGELGKTECWYVIDCSDDAEIIIGHNAKSHKEFVNMVNNNEWDKLLRKVNIKKG
                     DFFYVPSGTIHAICKGTLILETQQNSDTTYRVYDYDRTDNSGNKRELHVQKSIDVTNV
                     PHINFDTDYKIVSTSDFKCTTFVSNEFFSVYKLDVFGKCNFTHNTPFSLYSVLDGNGK
                     LIHNSVEYNLKKGMHFILPNDFGDFSFEGNLEIICSHI"
     gene            14155..15516
                     /locus_tag="KRO40_000265"
     CDS             14155..15516
                     /locus_tag="KRO40_000265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2091109.1"
                     /translation="MELFKAESKKYKKEFLKLLEQWVSIPSFYDRKTVSKDMPFGKGV
                     YDALNWFENLGRENNFKVKNIDNHAVQIEYGNGKEYVDIFGHCDVVNPGEGWDSEPFK
                     LNIIGDKLVARGVSDNKGPMIVNFLALKMIKDLDINLKRKVRLIAGGNEESGFKCIKH
                     YYSKEPYGVCGFTPDAKFPVLNGEKGGAIIKLISNIDDKSLYISGGIEFNTIPDKVYI
                     KNVEKLGKDNICFDINNISINYDNGNYIVYGKGGHSSKPEKSINPILATIKLLSENID
                     EKWTKDLYKLINQDNINGNLFGLNIEGKCGILSMVPTIINIVDGKLEVVLSVRYPEIL
                     TIEDIIKKFNLYMEQNNINKFELIGENLKQANYIDRNSKLVRSLHDIYIKYSGDLKND
                     VRVTSAGSYASEMNNSVIFGCEFPDGSFGNVHSANEFASLDRFITAIGIYAEAIITLC
                     NKI"
     gene            15604..17493
                     /locus_tag="KRO40_000266"
     CDS             15604..17493
                     /locus_tag="KRO40_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2091110.1"
                     /translation="MITKKHAIIVKSLSNKDGYMTSNELAIKLDVSTKTIKRYIADLN
                     SVLSKYDLVIASSRGIGYKLSGSKNNIARAVKEANKYIDGFLDDSEESRMSNIICMLI
                     NRNYMSIEAMAEELNLSIAAINKLSSKLKRKLEKYDLVIKSKPYYGSYIHGEEINIRQ
                     LITDYAIKLDEKSKVKVFLDDISENDIHCIESILEKHLREKDTIISDKDFNLLLSKII
                     VSVFRSKRGHSNNINLMDTSYRFHNYYFIENLMKEISDKIGFKLIEDEVIYISNYSGV
                     IAYKGTQGRKNTSEIEERISTVISSALQDIFLISGSDYTKDDEFMVAISDHIKRFLNR
                     ARANVKSNNPLLHQIKEKFPIAFNLAVFLSNKLETEFNLKLDEDELGYIAIHFAASNE
                     RMKKNTSKKICIVCHYGIGTGQLISEKLKQNISDLSVVGVYPVRYLDMAISQDVDLIV
                     STVELKGYEKPVLYIENIFDDSLIENVNKAFYEKEERRKIISNMFDEKAFFSIKANTK
                     EEVIISLSNKLKERDFIEESSIKSIIDRENISSTEIGNLVAIPHTIVKGDKKSIIGVG
                     ILENPIIWDKQEVQLVFMVFFNTKEKHNFSIFKYLYNFIKDEGGVRGIIKICDFNKLM
                     ALIGN"
     gene            17508..17963
                     /locus_tag="KRO40_000267"
     CDS             17508..17963
                     /locus_tag="KRO40_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2091111.1"
                     /translation="MGTNIFNKEYVFLNVDAKSKVEVLKFISKKAKDLNLAEDESLVY
                     EGLMAREEQFTTNLGESIAIPHTKNDAIENPAVVVLKFNEDVVWNEGEDKVKLAISLL
                     MPGKSKENIHLKLLSSLSRKLINKEFKDSLLKSDNVEEISNLINEALGL"
     gene            18022..18339
                     /locus_tag="KRO40_000268"
     CDS             18022..18339
                     /locus_tag="KRO40_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_311294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH2091112.1"
                     /translation="MNKKLVALCACPMGLAHTFMAAEAIEQAAKALGYEAKVETQGAD
                     GVQNELTRDDILGATMIIHAVAITPEGMERFDGCEVYEVELQEAIKNAEGVIKEIEED
                     LGI"
     gene            18364..19626
                     /locus_tag="KRO40_000269"
     CDS             18364..19626
                     /locus_tag="KRO40_000269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH2091113.1"
                     /translation="MAIKKKVINSSGASTTGGNNVGKSTPSSPTQSKGNGKWKEISKH
                     IMTGISYMIPVLVMGGLIGALSQLIPYAILGLDPSVGIVDAMNSGEFTGFKLSLLNIA
                     QLMSNFGFTLFGFAIPLFAAFCANSIGGKTALIAGFIGGYIANKPVGVPQFVDGQWTE
                     VVPVASGFLGAILIAFIIGYFVKWLNKSIKVSHNWLAFKTTFLIPLIASLACMVLMIF
                     IITPFGGLINESMKNFLTAAGAAGEYVYATALAAATAFDLGGPINKAAGFVALGLTTE
                     NVLPITARTIAIVVPPIGLGLTTLLDKRLVGRRVYDRQFYQAGKTSIFLSFMGISEGA
                     IPFALERPGFVIPLNIVGSVIGAITGIILGAIQWFPESAIWAWPLVDNLFGYIIGIAV
                     GAIFIAVGNIFYRNKLIKDGKLVVDYID"
     gene            19731..20795
                     /locus_tag="KRO40_000270"
     CDS             19731..20795
                     /locus_tag="KRO40_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2091114.1"
                     /translation="MDKIEKVREYFREYDIDGFLINSPTNKFYVGNLFSSSGYVFITK
                     ESQYIIVDFRYFEEIKRKSSLFNVVLMDKTRTHFDIINDICREQNIKEIGFEGNEVSF
                     DLYRSMSNKLSATLKSVDLSTLRETKNEDEIKYIKKACEIVDATFYHIVDFIKVGMTE
                     KQVENEIVRIIKDLGGQKESFDTIVASGLRGALPHGKASEKVIEYGDFVTFDFGAKYN
                     NYCSDITRTICMGTINKELEEIYNIVRKANEECIRVLRPGMTTGEIDKVARDIIGSYG
                     YANNFGHNLGHGVGIMVHEYPALAPESNEVLKEGMIVTIEPGIYVPSLGGVRIEDDVL
                     ITQDGCMRLTTSTKDLIVVS"
     gene            20849..22027
                     /locus_tag="KRO40_000271"
     CDS             20849..22027
                     /locus_tag="KRO40_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBH2091115.1"
                     /translation="MYNFDDKPDRVSEKCRKWDLNIIRDKFGDIREDFIPMWIADMDF
                     KIPTEIENKFIEAVRRGVFGYTYCYDEFYDSVIGWQKNMHEVNVEKEWITLTYGTVST
                     LHYVVQAFCKKGDSIILNTPVYDPFESSAKKQGVNVICNTLDVVNDRYYINFDKLEVQ
                     IKENKPKLMMFCTPHNPSGRIWTIEEMTRVATICKENNVILVADEVHAEHIHYGTFNS
                     ILKIGKELLENVILLTSPNKGFNLGGLKTSYSIVINKDIRDKFRNKLKQNSITSPNVF
                     GIIGLITAYNECHEWLSGVNEYIKSNYELLETWVNKYNKIKLMKMESSYLAWMDISGL
                     GISASEFTDKLAIDTGVLLEDGSHFVKDGEKYVRINLGTQKENVIEALNRMDLFLKSL
                     "
     gene            complement(22218..23276)
                     /locus_tag="KRO40_000272"
     CDS             complement(22218..23276)
                     /locus_tag="KRO40_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HBH2091116.1"
                     /translation="MNKKKITFIFVILILALILFSFFRSSSQNTKYSKTSYYLGTVNE
                     VTVFNVKESKSDKILNECDSILRYIDNKMSTHIPGSDVSKINDNAGKKFVRVSDDTFF
                     VVKEAIQYSKLSDGYFDITIGPLSNLWAIGTDKAKVPSDSKIQKLLPLIDYKNIILDE
                     KNKSIKLTKENMKIDLGAIAKGYAADKIVAYLKSEDVKKGLVNLGGNIFTLENGKNDK
                     PFKIGIQDPTSKNGESIGNIETTNKSVVTSGIYERFIEKDGKIYHHMLNPFTGYPFEN
                     NLSSVTIISDKSINCDALSTSTFGLGLEKGMNLINKIDNVDAIFITKDKKVYLTKGIK
                     DNFKLTDKSFSIEKLNKQ"
     gene            23343..23714
                     /locus_tag="KRO40_000273"
     CDS             23343..23714
                     /locus_tag="KRO40_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NusG domain II-containing protein"
                     /protein_id="HBH2091117.1"
                     /translation="MKKKDILLILGILVVITACYGIINVINSKNAGNIEIYVDNKLYK
                     TVSINAKEEFKIESRGGYNIVKIHDKGVEIVDASCPDKVCVHTGFINKPSQSIVCIPN
                     RVSIKINTNEKNDNQEDIISK"
     gene            23751..24425
                     /locus_tag="KRO40_000274"
     CDS             23751..24425
                     /locus_tag="KRO40_000274"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HBH2091118.1"
                     /translation="MVNLGNDWDELLKEEFEKDYYLNLRKFLIEEYKTRQIFPNMHNI
                     YEALKHTSYKDTKVLILGQDPYHGDNQAHGLAFSVQPQVKTPPSLLNMYKELKDDLGC
                     FIPNNGYLMPWADQGVLLLNTALTVRAHEANSHKNKGWEIFTDRVISILSEREDPVIF
                     VLWGSNARKKVELIDTSKHYILEAPHPSPLSASKGFFGCKHFSKINEILKKLGKEPIN
                     WQIENI"
     gene            24674..25513
                     /locus_tag="KRO40_000275"
     CDS             24674..25513
                     /locus_tag="KRO40_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBH2091119.1"
                     /translation="MNFKKLSNAKVSVMAVVLSVGILSGYSALNKQVTLVVRGEERTI
                     STFSSNVGDLLESQNISYDSNDIVTLDENTKLSNGDKIEVIDVKEKTVVETKDIPFEV
                     TVVEDGSLLKGDSKVKEEGKSGKSELIYKETYHNGKKVEKEFVKKVVKAEPVNKVVSK
                     GTKVEMQVASSRGESSRRMASSSSSSSSSNNGKNMRVVATAYTGHSITATGTKPKWGT
                     IAVDPKVIPYGTKVYIPQFDMVFTAEDCGGAIKGNKIDIYMNDSKTVYNWGRKTIDIR
                     ILK"
     gene            25757..25853
                     /locus_tag="KRO40_000276"
     tRNA            25757..25853
                     /locus_tag="KRO40_000276"
                     /product="tRNA-Sec"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:25791..25793,aa:Sec,seq:tca)
     gene            26004..26711
                     /locus_tag="KRO40_000277"
     CDS             26004..26711
                     /locus_tag="KRO40_000277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA threonylcarbamoyladenosine dehydratase"
                     /protein_id="HBH2091120.1"
                     /translation="MENNFTTRTSFLVGDDGIKKLNNSNIIVFGVGGVGSFTVEALAR
                     AGVGNITIVDFDDVDITNINRQIPALHSTVGRYKVDVMEERILDINPNINIKKIRSLY
                     NKDTSDEILTERYDYVVDAIDMVSSKIHLIETCEKKGLKIISSMGMGNKLDPTKIVVT
                     DIHKTSTCPLAKVMRKELRDRGIKKLKVVYSTEQPIELKKKVMNGRKVTPGSVSFVPS
                     VGGLIIASVIVNELLGQ"
     gene            complement(26853..27689)
                     /locus_tag="KRO40_000278"
     CDS             complement(26853..27689)
                     /locus_tag="KRO40_000278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2091121.1"
                     /translation="MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPT
                     NKNILIDGGDEDSENIIISYLRQKRIKTIDIIIATHPDSDHIGSLDNIIKKFNVNSIY
                     MPEQSTDSKAYQNLINSCTDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNS
                     IVFKLTFNDNSFLFMGDAEEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKIS
                     PDIAAISCGYKNQYGHPHREVINNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEI
                     DT"
     gene            27877..28782
                     /locus_tag="KRO40_000279"
     CDS             27877..28782
                     /locus_tag="KRO40_000279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2156 domain-containing protein"
                     /protein_id="HBH2091122.1"
                     /translation="MFFKDIELNSKKELDPYFDLVDYEACEYCFSTLYMWQHVYKTGY
                     YIGEDFAVLVGEYEGDSFSILPLAKKDKLPEVVDFVLEYFSKNNKKIYLRGITTEVVE
                     FLKEKYPGRFEYIEERDLFDYIYDAESLRTLAGKKNQKKRNHINYFLKEYAGRYEAKL
                     LDKENFDECLVLMKEWESNKEENNEFDESMDDELIGIKKIFNHYDILKDKVKVFGVYV
                     DGKLEAFSIGELLNPNMALIHIEKANPDIRGLYPFINQQFLVSEFKDVEFVNREEDLG
                     IEGLRKAKLSYHPCRFVEKYSVREA"
     gene            28791..29975
                     /locus_tag="KRO40_000280"
     CDS             28791..29975
                     /locus_tag="KRO40_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091123.1"
                     /translation="MEIRYAKEEEIESIKDIWSYCFNDTESFMKYYFNDKYKSENTVV
                     ALDEGKIISSLQLNQYKLLLNSKVYNTSYVVGVSTLPEGRGAGYMNKVMKFTLNELYK
                     KGQLVSILMPIDYRLYRRFGYEHCYDQIEYTINTDDLKNFKSSGKMIKSNLSQIDDLI
                     QIDRTFLNEVNGNVLKDEHYYENLFKEIQSEDGFLYIHEGNEKDGYIVYFLQEDKMFV
                     RELFYKNIDALKSMLKFIYNHNTQCKIVTISTPTIDKIRFILDNPKDSDIKIKPFMMG
                     RVINVKKFIEDIDIEKDINSSFNLLIEDKFIDENNGLFKISIQNKKVSVEQLDKKGAE
                     KPQEDFDIKLDINTLTQLSFSYIDVNEAIFLNDIKDVSEETLETLNCIFSKKNNYINE
                     YI"
     gene            30090..31391
                     /locus_tag="KRO40_000281"
     CDS             30090..31391
                     /locus_tag="KRO40_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEC/Rec2 family competence protein"
                     /protein_id="HBH2091124.1"
                     /translation="MGVIIIQIRRPLLIILMFVVAISFIITNNTKNDEELNDKIITIQ
                     GVVKGKIEKKRYNQYKVGVFLINDYTKNKNLKIGQKVNITGKFKSLDKMKYDDFDYGR
                     YIKSTGYKGIVYINNYKIIDKNKLYSLIGEIKFYISKTYRYLYKKNSDFINSILLAEV
                     ENLTEEQKEIFTRTGTSHVISISGLHTGILCVIISFLLRGINKLYKLLILSIFITLYC
                     IMVGASPSIIRSIAFVMIFYLSIFIDRKKDGISALSLIGIILIMNNPYVIYNVSFQLS
                     FLATLSILIFYNKINSIIKLSMVSLTISSNILTLPIIYYTFKGIPLLSIIGNLIIVPF
                     VGVIMYLSIASLIVFKVSVVIAKIISFFNSTFIESIFFLLEKISNLSFAYINIENPKF
                     YIVVIYYIGVFFYIFYIEGKEIKEQENELQGYYKECKREKL"
     gene            31345..32388
                     /gene="holA"
                     /locus_tag="KRO40_000282"
     CDS             31345..32388
                     /gene="holA"
                     /locus_tag="KRO40_000282"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HBH2091125.1"
                     /translation="MNYKDIIRNVKEKNFEKMYLFYGREYYLIENAIKAFKDSLNEGM
                     LDFNLDIIDGKEIVLNQLISSIETLPFMDDRKIVIIKDFELLKGKKKNFTDSDEKYLI
                     EHLDNIPDTTTIVFVVYGDVDKRKSLVKKIGNNGIVFDCDKLSDMDLFKWIKKSFALN
                     DVIIDNSQIMYFIEQEGYRDKSSEKTLSDLENEINKISSFVGKGNNVTNDVIDKLSQK
                     KVENDIFKLIDYIGEQNASNAMKILNDMIQEGESVLGIFSMIARQFKIIMQVRQLQLD
                     GYSTKLIADKLKMHQFVVGKALKQTKNFSDDIIVEILNYILESDYKIKTGLIRDTLAV
                     EMLVSRYCKREAI"
     gene            complement(32575..32841)
                     /gene="rpsT"
                     /locus_tag="KRO40_000283"
     CDS             complement(32575..32841)
                     /gene="rpsT"
                     /locus_tag="KRO40_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HBH2091126.1"
                     /translation="MANIKSAKKRISVIEKKTALNRVRKSQIKTAIRRFEDAVAAGNR
                     EDAVAKFQYAQKRIYQVASKGTIHKNAAARKVAKLAQKLNGMNA"
     gene            33283..34959
                     /locus_tag="KRO40_000284"
     CDS             33283..34959
                     /locus_tag="KRO40_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBH2091127.1"
                     /translation="MAKKVRIGDKLVEKGYITEEQLKWALSEQKNSGKRLGEFLVQEG
                     LIDSNLLISVLKELLDIESIFLEGTEIDTLATKMVPENICKRYTVFPFKIDGNKICLA
                     MSDPQDREAVQDVRRMSGKDVEIFISSTEDINKAIGHAYAHSEINKAMTEYNKNRTGG
                     VRETVILEEDVNAAPIVRLVNNILENAVRMEASDIHIEQSENYMRVRFRIDGMLREYM
                     RMNSAPYKAVISRIKIMSDINISEKRIPQDGRIYLKVDNKPIDFRVSTMPTNRDEKIA
                     MRVLDKSNFMVSKEVLGIDEHGSKIYDELINTPYGLILVVGPTGSGKTTTLYSMLNQL
                     NTENRNLLTIEDPIEYELPGVNQSQINEKAGLTFASGLRAFMRQDPDIIMVGEIRDTE
                     TAEIAIRASLTGHLVLSTLHANTAVGAISRLLDMDVESFLITSSVLGVISQRLTRKIC
                     EHCKVSYEADIGEKKALGIDVNESVTIYRGKGCERCNNTGYKGRLGIFEMLEITPEIK
                     ELIDSSANQREILKMARKQGMVSLKEDIVKKVLNGKTTVEEMIRIILMTD"
     gene            34971..36179
                     /locus_tag="KRO40_000285"
     CDS             34971..36179
                     /locus_tag="KRO40_000285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBH2091128.1"
                     /translation="MKSFKYTVIKEDGKKQTDVIEANDFNEARNLLRKRNLRVIEIKE
                     SKNKNIRLSSIKRKKDLGADQISHFCRQFAIIVSSGINSISGLETLARRSTNITLREE
                     INRIVAEIKVGSTIADSMLSSKSKFPKLLGAMVATGEATGKLDEVLKSMASFYASEHR
                     VKQKLRNAATYPLIVLISSFIMIFIFTTFMVPKMINSITTVGATLPLITRIVMGFGMF
                     MKKFWIIVLLVIILFIYQFKKYLKTSVGRAHKDRVINKIPVLGKGINCMVATRFSRAL
                     YLFVSTGYPLVQGLDYIIDSVNNTMAEKILASAKDGITRGEGLAENLERYTYFDSVLV
                     QMIAIGEQTGELENISRQMAEFYEYESEIYLNRMASMIEPVLIIAVGIIVAILVVSIF
                     MPMLSIYDAM"
     gene            36194..37906
                     /locus_tag="KRO40_000286"
     CDS             36194..37906
                     /locus_tag="KRO40_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PilN domain-containing protein"
                     /protein_id="HBH2091129.1"
                     /translation="MNKVYVSYYGDSISIVEGRYKHDKDKFYVKNFNVFSIEDIAQDF
                     SKEKYALLRYALENVKLKSRHVVFCLNTRDVILKPQKLPNMDKKDLDGFMKLEMDEMM
                     ALESDEYVFSYEVSSETPDNSDGDESSLNLIIGAIQKEEVNAIVEIMHEFDLVLDRID
                     TLSTAYLRMLKNLDYNDIMVTNISDNSTIINIYKKDTLFISDNIPIKITAKDMDMQLL
                     NVVEESKGLMNYYSSRNFGKVTDTILILGKRYSNKLIYETFSSAFSSYVSQGLTEIMD
                     ISDMITGDIDEDDINSIVELLGSMIEPKGKRDFENINFLPMDILRKQIKAKQMKNILK
                     IAPIVILILAIPYLCLIFSNNLANKELENVNGEIRNIESAYYQIGNIEKMIQSKSEEI
                     KVYDMLIGKKVKWENLLDDIDKNTPSKVELTSLSTTYQNLGTNNKADNSKSNKTTTDK
                     SSNNETKSSTKSDSNGDKTDNDLNEDKTTNVSEALTGNSETNSNNTDKDDKTPLYDKI
                     PNVINIEGNAKDSSYVGQFLYKLKGLYYFKDVKLHSIKSNAEDSNYTFSMTLYLKEGV
                     LTNE"
     gene            37899..38807
                     /gene="pilO"
                     /locus_tag="KRO40_000287"
     CDS             37899..38807
                     /gene="pilO"
                     /locus_tag="KRO40_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 4a pilus biogenesis protein PilO"
                     /protein_id="HBH2091130.1"
                     /translation="MNKDIFKKDIKDIFKMEVSLKGILIKVIILLAILSYGYFGLYPQ
                     YQKYIATKNSVKQATEKLNIYKEKTALMPKYEKQLEEVESELKEKSKNLLYDMQDGLF
                     LIGLDKKMKAYNIDLTSYDVGNVKEYEHFYGISTTISVRGDYRNVKKLMAYLEEQKNV
                     TQILDYTMTSYIEPEKEEEETTNNKDLIKNVNINKDTKIYWVEGENKWHLYKDCPLIK
                     EGEIIKNDKLLDRSTNYLCNTCVLRAATEKEAKKEVVAPKAEGVVDATFKFIMYTKEN
                     TTMILDTDNPSSWRPGKYNPFKSSAK"
     gene            38834..39400
                     /locus_tag="KRO40_000288"
     CDS             38834..39400
                     /locus_tag="KRO40_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH2091131.1"
                     /translation="MSLYKNNEKGLTLLEVIIAVFILTIVLSISYKVFNGITSAVKKQ
                     QIITDAQVNINLINKYLNRDLENCKELTKTGSGNNYEYNIEMPDNVVKYEVSIETKKN
                     TEVYSVTRIQNNTIDTENEVREEIIYNQPLVQNNKEMKETPFKIEKQTGKSIYTVSIY
                     YNESVQESHKNSNLNNKTYTFDVMSRIG"
     gene            39437..39964
                     /locus_tag="KRO40_000289"
     CDS             39437..39964
                     /locus_tag="KRO40_000289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH2091132.1"
                     /translation="MSKKNSERGFSLIEVLVAMAIMGIVLFAFFNIINTNNKANTKND
                     TDITSLNYVQSEIENLREKIKSGEFDFDSLDKLEDGTVVYEKLIDKSKKVVYDKVLSE
                     GDVSLYDTPYEKITTIKDEDGNLIDKGNITNKIKTIVEDKSGQIYKIAVTGKSMNDYS
                     SKKEVKIVTEIFKDK"
     gene            39985..41523
                     /locus_tag="KRO40_000290"
     CDS             39985..41523
                     /locus_tag="KRO40_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091133.1"
                     /translation="MRKWNKFKSERGAALVLVLVVVALLSIVGLIFSNQIANRIKSTK
                     TTNEGIQAKYLAETCVENSIDKAYEKLYDELEKMDNEFKSENQEKSISRSKLRNISDE
                     DFNNQDEENIEAERLGYMNNINFYLNKASSDLEKASMELKKLYDLDMLDYRDIEYVDA
                     NIISHRDSILEICKNYTSGDISKINEYILKEDIDSTTLIEAKLVNNDILLKKFLEENK
                     IENEHLNSAFSHTYKALDNISLAMQNMIEYRHTFHIDEPKVEVSNGIPDSQQYYELIQ
                     NPIINSMEYSWNSKWDTLENLLEILPNQTQGFNSLRVHLRNNVRKFEKLSDNISSGKK
                     NTAKNFLKYKELLYEISDQCNQLKSMSYEKIPVKYDNMALITTFDYIQNELLAEIKCR
                     LKELKPQEIDKTEGITIKIPFYKADYDMTKEGWPKLKENGSGAELSLMVTGDKNGIKE
                     VEVTDGKKNIIGLGVEENSNSKYKVDAIVNFNLNIDTNVVGNYDIKDKILINHDISSY
                     KKVN"
     gene            41619..42701
                     /locus_tag="KRO40_000291"
     CDS             41619..42701
                     /locus_tag="KRO40_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV pilus twitching motility protein PilT"
                     /protein_id="HBH2091134.1"
                     /translation="MYIYDLLEQGIRLNASDIHITVGTNPVARVKGGFVKLSEQILTS
                     EVTMQMAKDIAGESMFKVIEEHGEADFSASLKTGERFRVNAYRQKGNYAIAIRTITAE
                     IPTFEKLGLPESIKSFTEKHKGLVLVTGPTGSGKSTTLASMINIINEKQQKHIITLED
                     PIEYVHHHKQSLVNQREVGTDTESFHSALRAILRQDPDVILIGEMRDPETVSIALTAA
                     ETGHLVFSTLHTVGAAKTIDRIVDMFQPSQQQQIKTQLSTVCEGVVSQQLLPTADGKG
                     RIAAIELMFATPAIKNLIREGKTYQIPNMIQTGVKVGMKTMDQDLMELYKNGKITKDM
                     ALSRCTDQEFMTRMIGGVNYNGYYNR"
     gene            42682..43464
                     /locus_tag="KRO40_000292"
     CDS             42682..43464
                     /locus_tag="KRO40_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBH2091135.1"
                     /translation="MDIIIVNLYVFIVGIVFGSFFNVCIFRIPEGISISRPPSHCMSC
                     NTRLKPIDLIPVLSYLMSGRKCRYCYEKISSRYAIVELITGLLFLTVFMLYGISTSTI
                     YYLVLVSLLIIITFIDIDHFIIPDKILVFGAIFSMIFNLLFKEIPVKDSILGVFICGG
                     SVWIIVLLIEFVIKKECMGGGDIKLFAMLGLYMGVKNGLLTALLSVYVGAVYGICVII
                     ISRIKGKEYNSVIPYGPFISIGALITILCGKKLLELYFSMVI"
     gene            43566..44216
                     /locus_tag="KRO40_000293"
     CDS             43566..44216
                     /locus_tag="KRO40_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBH2091136.1"
                     /translation="MEYIIIISLFFAHLINKSLCVFCDREKKNLYNTFFIYIITVVLS
                     VLIYLKFGISVECVQYMVLIPFLIIISIVDYYTIYVYDITIVSGIIVQGIIFLAFFNI
                     AQFDYINHIFGLLIGFIIPYIIAKLTKGLGYGDVGLYSLCCFALGNNYGFYVIVLSFI
                     LAFLFFIILYITKVFKDVDIRKQIPFTPFISLSTILIIFTEYNIFNFYYNLLYKFI"
     gene            44230..44790
                     /locus_tag="KRO40_000294"
     CDS             44230..44790
                     /locus_tag="KRO40_000294"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HBH2091137.1"
                     /translation="MYVVVGLGNPGKKYEKTRHNVGFDVIDILAKEYNISVTKIKHKA
                     LIGEGRVGTEKVLLVKPQTYMNLSGETLIDIYKYYKVDLSNIVVVYDDIDLEVGKIRI
                     RKKGSGGTHNGMKSITNCLGSNDFPRVRVGVSKPEAGQDLADFVLSRFRKEESDNINE
                     ALEKAADAIDSIIRENIDMSMNKYNG"
     gene            44807..48193
                     /gene="mfd"
                     /locus_tag="KRO40_000295"
     CDS             44807..48193
                     /gene="mfd"
                     /locus_tag="KRO40_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HBH2091138.1"
                     /translation="MNDVFLYPLQNSKEYKDIINCIKNTKGSLLVNGLLPVQKPHISY
                     SIFNDLSRQMIFITSSDLEAKKVYEDLSFYMEDKVEYLGFQDIYFYHLDAKDRNEEAK
                     KLKVLLKLANKEKIILVTSIEAVLRKYIPKQVLLDSVSHYKVGDSLDLEKLTEKLVSL
                     GYERVSKIEGFGQFSIRGGIIDVFSLEYTNPIRMELFDDEIDSIRTFDVYSQKSIDKL
                     QQFSITPSREFIYPEKTTDALVKLKKETTKNTDEGTFQNIDYISSKTYFEGVENYIDY
                     IYPEENKSIFTYLADDAIVFINDITRLKERCENYINEFRENYKLNLERGLAIKNQGKL
                     LYHYTDLEYLVKDKSVVLNSLLPKSINNFSIKSIINFESREVPTFNGKVDLLVEELNR
                     LKYNGYKIILATNTLERANKLGKDLLDKGLETTISKDRDIEIKSSQVIIVPAHINSGF
                     QYKSIKFVVITDNEMIGVYKRASKTSNKKVKKGKKIESFLDLSVGDYVVHENSGVGRY
                     TGIEQITVNAIKKDYMKIVYQGGDNLYVPIDQMDKVQKYIGAEVEKVKLNKLGTNEWT
                     KAKAKVKKEIEDMTKDLIELYAKREKIQGYKFSKDTPWQAEFESLFPYQETEDQLKAI
                     EETKKDMESSKVMDRLVCGDVGYGKTEVAIRSIFKACMDQKQVAVLVPTTILAQQHYN
                     TFKERFENYPLRVEVLSRFKTPKQQKQIIEDAKKGLVDILIGTHRIISKDINLPNLGL
                     VVIDEEQRFGVKHKEALKKIKSTVDVLTLSATPIPRTLHMSLSGIRDMSVIEEPPQER
                     HPVITYVTESKESVIQDEIERELSRGGQVFFVYNRVEHIEEMASMIQKLVPDARVAVA
                     HGRMTSKSLENIILGFLNKDYDVLVCTTIIETGMDISNANTMIIYDADKMGLAQLYQL
                     RGRVGRSSRQGYAYLLYEKDKTLSEIAEKRLKAIREFTEFGSGFKIAMRDLEIRGAGN
                     ILGSQQHGHMAVIGYDLYVKMLNDAIKKVKGEPIVEEIDVEIDLSVNAYIPDNYIKDE
                     LIKIEMYKKIASIENKEDMLDIQEELEDRFSDIPKPVQTLLTIAYIKSLCKILKIEKI
                     RQLKDEILLVPITKYRTKQKIGYNIVTELEELLEKMCKVK"
     gene            48224..49219
                     /locus_tag="KRO40_000296"
     CDS             48224..49219
                     /locus_tag="KRO40_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH2091139.1"
                     /translation="MKKVITLVIAMILVVSVTACSSSKGETVATVEGTKISSDEFKKT
                     IALYKDSMEQTYGKDIWDKEVEKGVKYKDKFKDLILDQLITTEVIYSQAKKDNLLPKK
                     EDVEKSFKELKDAMGKDEKYKEQLKKLGIDDEFLRDQQEKDLAMQNYQSNFAKKTKIS
                     DEEMKKYYDTHKDEFKKDEVEASHILLKTVDDNNKPLSDKEKAEAKKKAEEALKEVKS
                     GEDFAKVAKKYSQDTSASDGGKLGFFSRGQMVAEFEDAAFSMKKGEVSDLVETQYGYH
                     IIKVTDRINEQTSFEDAKETIKDQLLKNKYQEQIEKLTKEAKVEKDEKVINKITI"
     gene            49343..49882
                     /gene="spoVT"
                     /locus_tag="KRO40_000297"
     CDS             49343..49882
                     /gene="spoVT"
                     /locus_tag="KRO40_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein T"
                     /protein_id="HBH2091140.1"
                     /translation="MKATGIVRRIDDLGRVVIPKEIRKTLRIREGDPLEIFTAKDGEV
                     ILKKYSPIGELNEFSQEYAETLAEVLGYGVLITDLDSIIAVSKLPKKDYKEKSISDEL
                     EAIISERTVKYSKDKNILPLFKEDQKEYTSQVIMPIISASGDCIGSIVVVSKDKDTIA
                     ESEEKSLKIAANFLGKQVQ"
     gene            50002..51615
                     /locus_tag="KRO40_000298"
     CDS             50002..51615
                     /locus_tag="KRO40_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH2091141.1"
                     /translation="MNNNKNKDSFLKGALILGLAGVIVKIMGGFFRIPLGNMIGSEGM
                     GYYQAAYPVYTLFLTLATAGFPTAVAKLVSEKVAIGNFKGANKIFKVSHTVLFITGII
                     SFCILFFGADYIVTNVMKNPGALYSMKAIAPALLFVPAMSAYRGYFQGRQDMTKIAVS
                     QVAEQFFRVVLGLTLAYLLMKSLGQTFGAAGAISGATIGSIASMLYLVFAYMLGRKER
                     RAEIDASQRFKDERVSYIFKKLLTVAIPITIGASVMPLVNMIDNVIVIRRLMEAGFTY
                     KVANSMFGQLTGMAMATINLPAVITTAMSMSLVPAISKAYALGNKSKARKDTKSAVKV
                     TLLIVLPCAFGMASLAIPIMGLLFPHEPSSVGTILFTLTPCVLFLGLIQTLTGIIQGM
                     GKPIVPVIALCVGMLCKIVISYTLTGIPDINVLGSAFGTVTAYFVAAMINLLYVKKHM
                     NVNFSKKEFIIKPFITVMTMFIMVKLSYGALVGFLGNSISTIIAICVGGIVYVVVILG
                     IGGIKKEEILTMPKGDKLYKLLKKVKLIR"
     gene            51722..53170
                     /gene="mazG"
                     /locus_tag="KRO40_000299"
     CDS             51722..53170
                     /gene="mazG"
                     /locus_tag="KRO40_000299"
                     /EC_number="3.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside triphosphate pyrophosphohydrolase"
                     /protein_id="HBH2091142.1"
                     /translation="MGKISIVGLGPGDYSLISQGVLESLINSPKVFFRTEKHPIIDKL
                     KETIQYTSLDYFYEKEENFDNVYLKISEFIIEESAKGDLVYAVPGHPRVAEKTVSIIE
                     RLANEKHIAVEILPSMSFVDAMFNYLAIDPSEGFKLVDAFEIENSYIDLDTSMIITQV
                     YDKFIASNVKLKLMEHYDYNQEVCIVNGAGVKDLESKKFIKLCELDRNENFFDYLTSL
                     YIPKSSKKMYNTVHDLEIIVNTLRSPSGCEWDKKQTHQSLKNSVIEEAYELCNAIDNN
                     DIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVVNGICKKLIHRHPHIFSGAKLDMS
                     KFEKTWEELKKEEKGESTITDGLRRIPKHLPALMKASKVQHKAALVGFDWDNVEDVFK
                     KIEEEYQELLDEHRVGNIKYIKEELGDLLFSIVNLARFLDIDSGEALNCTTEKFINRF
                     DFIEKSAMNLNKKLEDMTLEEMDEFWNQAKKQ"
     gene            53259..53537
                     /locus_tag="KRO40_000300"
     CDS             53259..53537
                     /locus_tag="KRO40_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003153447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HBH2091143.1"
                     /translation="MNKAELVSKMAEKSGLTKKEAEAALNAFMSSVQDALVNNEKVQL
                     VGFGTFETRERAARQGRNPRDPEQVIDIPASKAPVFKAGKGLKDIING"
     gene            53609..53851
                     /locus_tag="KRO40_000301"
     CDS             53609..53851
                     /locus_tag="KRO40_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HBH2091144.1"
                     /translation="MRLDKFLKVSRIIKRRTVAKDACDKGIVTINGKVAKSSSEVNIG
                     DTLEIQFGEKKMKFKINEVKEHVLKNDAKEMYEILE"
     gene            53913..54167
                     /locus_tag="KRO40_000302"
     CDS             53913..54167
                     /locus_tag="KRO40_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YabP"
                     /protein_id="HBH2091145.1"
                     /translation="MEQNITLKDRSKLVISGVEHIYSFNDKRVELKTSVGEMVIEGEN
                     LDMSKLSIDENIISIDGTINSMVYAKPKKPQESFLKKVFR"
     gene            54168..54701
                     /locus_tag="KRO40_000303"
     CDS             54168..54701
                     /locus_tag="KRO40_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091146.1"
                     /translation="MIPFTQDVSIFYATIYGGILIGVLFDFYRGLRGNFKFINYFAII
                     FDVLFWFLATVIIFVTINLTEFFDLRYYHFVALFIGFILYYNTISKIVLSIINKIIRF
                     VRNSFKKVTHYIVSFLNNLYYVIIYSLHLLFDIIFYIPNIFIATRKSIKRKSNKKLKN
                     KKKSKPKKKKNKTKKRV"
     gene            54707..54991
                     /locus_tag="KRO40_000304"
     CDS             54707..54991
                     /locus_tag="KRO40_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HBH2091147.1"
                     /translation="MNLRKKFSGQIIVISLFLGISIFSMMTGFVFEYTKAKEYKKEIA
                     SLNKQLKKTEIQINSLKKDEKSYEGDLEDIARKRLNMVKPNETVYVDINR"
     gene            55104..56024
                     /locus_tag="KRO40_000305"
     CDS             55104..56024
                     /locus_tag="KRO40_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ppx/GppA family phosphatase"
                     /protein_id="HBH2091148.1"
                     /translation="MKVGAIDIGTNSMRLLIADYRDGNFINRKKFVNTTRIGYGVDSK
                     GYIKEDAIKRNIKALKEFSDKCNDEKCEKIYCMGTSALRDSKNGDYFVKLAKEETGID
                     VDIVTGIEESNLGFKGVLEGIQGDDTIIVIDIGGGSTEFIVGDSEGIKFNKSENVGAL
                     RMTERFLKHDLIEDEEFEAMSSFIYGEIDKTLNHIKDRGLKTLIGIGGTITSLSAMNQ
                     ELEIYSMEKIHNSKIHKKEIEEILQKLIKMTLSDKKNLKGLQEKRADIITAGVKILNI
                     IMEKLEIEEITVSEYDNLEGLICQKSKKMY"
     gene            56114..58486
                     /gene="spoIIE"
                     /locus_tag="KRO40_000306"
     CDS             56114..58486
                     /gene="spoIIE"
                     /locus_tag="KRO40_000306"
                     /EC_number="3.1.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein E"
                     /protein_id="HBH2091149.1"
                     /translation="MQRSVAVVKNKTVKPNVIKLISGYIDFTTAAFAVMGFLLSRSII
                     VDSVAPLGIAFFICASKIDKYKIPVFISTLLGILLSSNDFGNVAKYAVCLTIFMAMNK
                     KLKLSDSIAKVAFIGAIILLPISMGQAFFSNRYVYGLLIAGVESIIMFISIYVFSYGI
                     GLMANVNNRMSVRTEEAISISLLLTFSIMGIGDISLFGISIRTILSTVLILLTSIVGG
                     ATMGASSGVIIGVASILNNMTSAVYMGIYSFSGLISGAFNKINKYFCILGYILSWTII
                     YLYTSGITSNMMQLRDILLGCLIVLVLPERLFNKIEKLIKSNVASNEIVYDYIMRSKN
                     LTNSRLNSIYKTYDDLADTFDKIREKDKVLDQRDIANVIDMIHNDECKSCSMRRMCWE
                     SRFNHTYTMIYNILEKIEEKGELSLNDIPKNFRKECMKPESIVKISNHYYKMFVLDYD
                     WSVKFSESRKLIANQIRSISKSIKSLSQDLEGDIMLDIEKEKNIYEQLERYDITVDKV
                     SYLTKSNSEFEISIEKKTCHDGCMCEDKIVNIISDLVGENMSVRKIGCHCLGGKCKAT
                     FVKSQKYKAVTEVSAMSRDGHILCGDNYTYMEINDGKYMMAISDGMGKGKKAYEESSA
                     TIDILEKMIDAKIKDEIVIDTINNMLLLKSSEEMFSTLDLGILDLKRGCLETIKMGAC
                     STYIKREDGEVDLISSSSLPVGILSDVKIDRKNVKVKEGDYVIMVSDGIVDAGRNNNL
                     GDNWLIYFLKNIETTNPKEISNLILDRALELQALQIEDDMTVLVTKICTK"
     gene            58837..60729
                     /gene="pepF"
                     /locus_tag="KRO40_000307"
     CDS             58837..60729
                     /gene="pepF"
                     /locus_tag="KRO40_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBH2091150.1"
                     /translation="MNRKLCKAIIPLFISIFCMLIISIKADQGYQKNNDRAITVMNNN
                     DTEDDAEKKQEIDYEKTCWNLQSLFKSDDQWKKELKSFDKDTKELKNYIGKVTKSPTH
                     LSFALNIKEKLDIRLNKLSAYVKLKQDTNKNSYKYLDMNDSMSKSYGNYMGICSDLEL
                     EILKLSNKDYKKIISNKNINRKYGAYLRDIRRNKVHYLDDKSEDILSKVSSISSLPSQ
                     VYELFRNMDRKTNLTPAQYASELESSDRENRKKAYQDELITYNDNINTIAGLITGQVK
                     KNIFYSQERGYESSLEMYLESDNVDEKVYNNLIRTVNSNMDSLHKYIDLRKKVLKLDK
                     VHSYDMFVPMVKAVDNNINYEKAQSIVYSALSPLGKEYNDVVYKAFNEKWIDVYSHEN
                     KVSGGYCLSVYENHPYILLNYNNSLGSVSTLSHELGHAVYEYLSSKNQNYFNSNPSIF
                     THEVASTTNEALLYEMLIKEAKGNDEKAYYITQYLDLIKDTLYTQTMYAEFEKTIHEL
                     VEKGKSVNALVLNDVWGQLLKKYYGQSYELDQLSKVGWARIPHFYNSFYVYKYATGCS
                     AGVSFAQDILKNGSDNYMSFLKKGSSDYPINLLKSSGINLTNTKPIENTIKKFDSLVA
                     ELEKLL"
     gene            60843..61808
                     /gene="galU"
                     /locus_tag="KRO40_000308"
     CDS             60843..61808
                     /gene="galU"
                     /locus_tag="KRO40_000308"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBH2091151.1"
                     /translation="MQVKVKKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIE
                     EAVASGIEEILIITGRNKKSIEDHFDKSVELELDLEKKGKKELLEVVQNISNMINIHY
                     IRQKEPKGLGDAIYCARHFIGDEPFAVMLGDDIVDNDVPCLKQLTDAYEEYRTTILGV
                     QKVNQEDTNKYGIIEAKNIEGRVYKVKDMVEKPESGKAPSNIAILGRYIITPEIFDIL
                     KDLPPGKGGEVQLTDALKILSKKEAMYAYNFEGKRYDVGDKLGFLEATVDFALKKEDL
                     KEDFIKYLKHVCSEFDKNNNVLYNNTDEKIDLIEVNEARELEIQK"
     gene            62308..63912
                     /gene="rho"
                     /locus_tag="KRO40_000309"
     CDS             62308..63912
                     /gene="rho"
                     /locus_tag="KRO40_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor Rho"
                     /protein_id="HBH2091152.1"
                     /translation="MRRIFLILDDKVLEGLGSKTLVELREIAKELKIKSITTYKKNEL
                     IEIINSKSKNEEKVNEETKEKNEDIKEDIKNRKENIERESIEKEVEYKSPTKSYNKKE
                     IDTQNISQNQEHRNQRNDYNKTTSVNDSNKSSNISNRMVRNNNKNYYMPKQVDESKIV
                     DEFNTSKEDEVVGVLEILPDGFGFLRGSNYLSTEGDVYVSPSQIRRFNMKTGDKIKGI
                     TRHPKSGEKFRALLYVQKINDENPDTAIQRNAFETLTPIFPEERLTLETNRNEIATRI
                     IDLISPIGKGQRGLIVAPPKAGKTVLLKSVANSIAKNHPNVELIVLLIDERPEEVTDM
                     KESIEGDVIYSTFDQVSSHHVKVAEMVLNRAQRLVEHGKDVVILLDSITRLARAYNLT
                     ISPTGRTLSGGIDPGALHGPKKFFGAARNIRQGGSLTILGTALVETGSRMDDVIFEEF
                     KGTGNMELHLDRKLAEKRIFPAIDIYKSGTRRDDLLLDDEEKTALWRLRREMSNNSVM
                     EITDKVIELIKRTKDNKEFVKSIKNL"
     gene            64065..64265
                     /gene="rpmE"
                     /locus_tag="KRO40_000310"
     CDS             64065..64265
                     /gene="rpmE"
                     /locus_tag="KRO40_000310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018591942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L31"
                     /protein_id="HBH2091153.1"
                     /translation="MQKEIQPKYNPVEVRCACGNTFVAGSTKDEIKVEICSECHPFYT
                     GKQKNIEKGGRIDKFKKRFKMD"
     gene            64410..65303
                     /locus_tag="KRO40_000311"
     CDS             64410..65303
                     /locus_tag="KRO40_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1385 domain-containing protein"
                     /protein_id="HBH2091154.1"
                     /translation="MAKQAVGGQAVIEGVMMQSKDKRAVAVRKSDGEIALKEDRIKSW
                     VRDKNIDKIPFVRGSFVMIDTMIQGIKSLNFSSEFFMEEAEEDKFDLFIKKIFKDKAN
                     DIIIIFSLVIAMLLSAGLFIFIPTLVGGAFSKVMPNDFMLNLIEGIIRIAILFAYIVL
                     ISRSKDIERVFQYHGAEHKSIYCYENDLELTVENARKFKRLHPRCGTNFLFIVMAVSI
                     ILFAFFGWPNPILRIFMRIICVPIVAGLSYEVIRVLGKYDNGFTKIIAYPGMMLQYFT
                     TKEPDDEQLEVALEALKAVVD"
     gene            65321..66169
                     /gene="prmC"
                     /locus_tag="KRO40_000312"
     CDS             65321..66169
                     /gene="prmC"
                     /locus_tag="KRO40_000312"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HBH2091155.1"
                     /translation="MTIKDIIIKYSDKLKDISDTPRLDTELLLQKTLGVDRLYIHLNL
                     NKELTEEQKTKFMGFAEERLNGRPIAYIVENREFMGLDFFVKEGVLIPRPDTETLVEE
                     IIEICREKKDVSILDIGTGSGAITISLAKYIENSKIMSFDISETALEIAKKNAIINEV
                     GEKIKYINSDLFTAISDSNIKFDIIVSNPPYIKKQDIETLHKQVKDYEPYNALEGGED
                     GLDFYRRITEQGKKYLNKCGILAYEVGHNQAEDVINIMKSNGYKKIYTKKDIQGIDRV
                     VIGYNI"
     gene            66213..67277
                     /gene="prfA"
                     /locus_tag="KRO40_000313"
     CDS             66213..67277
                     /gene="prfA"
                     /locus_tag="KRO40_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HBH2091156.1"
                     /translation="MLKKLEVLEDTYKDLSEKIGDPDVINDQKVWQKYIKEHADLEPI
                     VMKYREYKSVLDSIKESKEILQEESDEELRELAKMELAEMEEKVAPLEEEIKILLLPK
                     DPNDDKNVIVEIRGGAGGDEAALFAGDLFRMYSRYAERRRWKIELLSASDTGVGGYKE
                     VSFMIKGKGAYSRLKYESGVHRVQRIPSTESGGRIHTSTSTVAVLPEVEDVEVEINPN
                     DLRIDVFRSSGNGGQSVNTTDSAVRVTHIPTGEVVSCQDGKSQLKNKEQALKILKARL
                     YDKALAEQHKDIAAERKSQVGTGDRSERIRTYNFPQGRISDHRINLTLYKLDAFLDGD
                     IDEMIDALITVDQTEKMTAI"
     gene            67406..68086
                     /locus_tag="KRO40_000314"
     CDS             67406..68086
                     /locus_tag="KRO40_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ZIP family metal transporter"
                     /protein_id="HBH2091157.1"
                     /translation="MILKVTIIGLLAGVIGTGLGGVISAIFKREVDKYLSFFMGLSGG
                     IMLAVVVFDLMKESMDKMGIINTVIFTFVGALITMYIKTKLDVSGNMASGYLIFISIL
                     LHNLPEGLAIGSSFMSTESLGITLAIVIGLHNIPEGLAMALGLVCNKMKLSKVILFTV
                     IAGLPMGLGSFLGVYFGGVFTSLIGVFLATAGGTMMYVVLEEIFPHSKSVYCIIGFLL
                     GTMIVNYI"
     gene            68115..69155
                     /locus_tag="KRO40_000315"
     CDS             68115..69155
                     /locus_tag="KRO40_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HBH2091158.1"
                     /translation="MKTIISNIDINNIDYEEIKIQAKLLREGKTVIFPTETVYGLGAN
                     ALDENAVKKIYEAKGRPSDNPLIVHIYEKEEVYDLAKDISDKAKLVIEKLWPGPITII
                     LNKKDIIPYKTSGGLDTVAIRMPSNVIARAIIKEAGIPIAAPSANISGRPSPTKAKHV
                     YEEMNGRVDGIVLGGDSNFGLESTVLDLTEETPMILRPGSITKEVLEELLGEVKLDPS
                     LSKKEDNQKAKAPGMKYKHYSPNADVYIISGKRENVATKINDMIKSNRDKGLKTGVMC
                     ISRNREFYDGEVIDLGNSLEEVASNLFDALIEMDKKGVDVIYSEEFPKTGVGQAIMNR
                     LLKSAGYKVIKA"
     gene            69172..69621
                     /locus_tag="KRO40_000316"
     CDS             69172..69621
                     /locus_tag="KRO40_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight protein arginine
                     phosphatase"
                     /protein_id="HBH2091159.1"
                     /translation="MNILIVCTGNTCRSPMAEAILRKAIKESGRSIEEYSISSAGIST
                     ANGMGASENSIEVLKEIGIDLSNHRSKVITKKLIDESDIILTMTKSHKEILVQAVPKC
                     KEKVYTFKGFANKNEEDISDPFGGNLDIYRSTMREIMYSVNEIVKKI"
     gene            69638..70090
                     /gene="rpiB"
                     /locus_tag="KRO40_000317"
     CDS             69638..70090
                     /gene="rpiB"
                     /locus_tag="KRO40_000317"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBH2091160.1"
                     /translation="MKIGLGCDHGGYNLKKEIISYLESKGIECVDYGTNNATDSVDYP
                     VYGEIVANSVINKEVDYGILCCGTGIGISLAANKVPGIRCAVVSDVFSAKMSKAHNDA
                     NMLSLGERVLGKGLALEIVEAWINTDFEGDRHARRVNMIKSIEEKHNK"
     gene            70126..70755
                     /gene="upp"
                     /locus_tag="KRO40_000318"
     CDS             70126..70755
                     /gene="upp"
                     /locus_tag="KRO40_000318"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HBH2091161.1"
                     /translation="MSKVVETNHPLIQHKLTLMRDKNTGSKDFRELLTEIAMLMGYEI
                     TKDIPLKDVEIETPIQKTSSKVVAGKKLAIIPILRAGLGMVDGLVSLMPAAKVGHVGL
                     YRDPETLKPVEYYCKLPQDIGERDIIVVDPMLATGGSAVAAIDLLKSKGAKSIKLANL
                     VAAPEGIAEVQKYHDDVDIYVASVDERLNEHGYIIPGLGDAGDRLFGTK"
     gene            71056..71871
                     /locus_tag="KRO40_000319"
     CDS             71056..71871
                     /locus_tag="KRO40_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EF2563 family selenium-dependent molybdenum
                     hydroxylase system protein"
                     /protein_id="HBH2091162.1"
                     /translation="MKNCIVVRGAGDLATAVIHKLHNSGFKVVALEIEEPLAIRRQIS
                     FCEAVYEKKVTVEGVECIFCNTEKEIEEVLSQHKVALIIDPKGEKLSKLNPIVLVDGI
                     LAKKNLGTTKDMAPLTIALGPGFCAGEDVDVVIETMRGHNLGRIITNGRAEKNTGVPG
                     AIKGFSKERVMHSQYDGIMENVCKIGDIVEKGDLLCYINNYEKKHEVRATISGVLRGL
                     LKDGAKVNKNLKILDIDPRKEEVKNAFTISDKARCIAGGVLEAILNNGIYPQN"
     gene            72097..72534
                     /locus_tag="KRO40_000320"
     CDS             72097..72534
                     /locus_tag="KRO40_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dCMP deaminase"
                     /protein_id="HBH2091163.1"
                     /translation="MRPSWDEYFMEIAEVVKKRSTCIRRQVGAVIVRDKQILTTGYNG
                     SPRNLEHCENIGCKRQELNIPSGERHELCRALHAEQNAIIQAAHNGISVDGATLYVTT
                     RPCVLCAKMCINAGILKIVYEGDYPDDMSTELLKEAGIELIKF"
     gene            72719..72946
                     /locus_tag="KRO40_000321"
     CDS             72719..72946
                     /locus_tag="KRO40_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AtpZ/AtpI family protein"
                     /protein_id="HBH2091164.1"
                     /translation="MSKRNTHTEIAKLFSLISQIGLMIVISILGCTFLGKFLDSKLNT
                     TPVLTIIFLLLGVGGAFSGVYKTLIVYTRRK"
     gene            72951..73337
                     /locus_tag="KRO40_000322"
     CDS             72951..73337
                     /locus_tag="KRO40_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase subunit I"
                     /protein_id="HBH2091165.1"
                     /translation="MDIKLLNQVRSVTKGIVIFDVVLIVLMLITSTLSKPVLLGLIFG
                     SIIAMLNFRLLAISLEKSVTFPAGKAQAYASAQYAVRLFIMAVVLIASATVPHLNIIG
                     TALGLLSTKFVILSKNFINKLKRKEA"
     gene            73340..74044
                     /gene="atpB"
                     /locus_tag="KRO40_000323"
     CDS             73340..74044
                     /gene="atpB"
                     /locus_tag="KRO40_000323"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HBH2091166.1"
                     /translation="MNQAHYYLIGNFKISETILVSWGIMAFLAIASYFLTRNLKKVPT
                     SKVQIFLEFAVGGLAKMVTDVMGKNTVKRMPYMIPYIGSLFLFFACSNLSPLLGLRSP
                     TTDLDTTAAWAMITFFMIYFAGVKFKGLSYFKELAQPLAIMLPINIIGELARPISLSF
                     RPFGNILGGTIIMGLFYQLLGFISSLIPGLSIPIGEILIPVPLHLYFDLFAGLLQAYI
                     FIMLTMVFISSAGELD"
     gene            74113..74373
                     /gene="atpE"
                     /locus_tag="KRO40_000324"
     CDS             74113..74373
                     /gene="atpE"
                     /locus_tag="KRO40_000324"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F0 subunit C"
                     /protein_id="HBH2091167.1"
                     /translation="METAIVAAASAIGAGIAVATGIGAGIGQGIAAAKAAEAVGNQPE
                     AKGDITSTLLLGVAIAESSAIYGLVISIILLFVNPFFKYLGM"
     gene            74496..74993
                     /gene="atpF"
                     /locus_tag="KRO40_000325"
     CDS             74496..74993
                     /gene="atpF"
                     /locus_tag="KRO40_000325"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HBH2091168.1"
                     /translation="MEKALVGITWEFVFQIVNTFIIFLLLRKLLFKPVLNIIESREND
                     IKSDLAEGEKAKNEGLALKKEYESKINFAKDEGQEIIKQATIRAEQKSDDIVNTAKKD
                     ALDIKEKANKDIEQERQKVINEIKNDISNIALLAASKVIEKDLDKSKHEELIENFIKE
                     VGEAK"
     gene            74990..75535
                     /locus_tag="KRO40_000326"
     CDS             74990..75535
                     /locus_tag="KRO40_000326"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HBH2091169.1"
                     /translation="MINVIANRYAEALFQLGEEENSTDVLFKELEKVVDMMTKVSKDF
                     YKVLKSPLVSKSEKKNLVEIIFSKEVSSNIKNFLKVLVDKDRISYLEDIELAYKELLN
                     KKNNVIDGVAISAIPMSETDIKELEVKLSNKYNKNVTIENVVDKTILGGVLVRIGNEQ
                     IDGTVKTRLDKMKEKLSEVIS"
     gene            75552..77054
                     /locus_tag="KRO40_000327"
     CDS             75552..77054
                     /locus_tag="KRO40_000327"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003405060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HBH2091170.1"
                     /translation="MNLKPEEISSIIKQQIKNYENKVELTDTGSVLTVGDGIASVYGL
                     EKAMSGELLEFPGEIYGMALNLEEEVVGAVILGDDSEIKEGDIVKRTGRIVEVPVGEA
                     LIGRVVNSLGQPIDGKGPIAYTKTRPVESEAPGIIDRRSVYEPLQTGIKSIDSMIPIG
                     RGQRELIIGDRQTGKTSIVIDTILNQKGKDVICIYVAIGQKRSTIAQLVSSLEKGGAL
                     DYTIVVSATASESAPLQYIAPYAGAAMGEEFMYNGKHVLIVYDDLSKQAVAYREMSLL
                     LRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPIIETQAGDVSAYIPTNV
                     ISITDGQIYLQPELFYSGVRPAVDPGISVSRVGGSAQIKAMKKVAGTLKLAYSQYREL
                     AAFSQFGSDLDEDTKKRLAQGERIVEILKQGEHQPIKVENQVMIIYAVINNHLEDIPI
                     DNIARFESELYAFVDNNYPEISRKILGGEDFTHDLTDAINEFKEKFVVEV"
     gene            77082..77960
                     /gene="atpG"
                     /locus_tag="KRO40_000328"
     CDS             77082..77960
                     /gene="atpG"
                     /locus_tag="KRO40_000328"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit gamma"
                     /protein_id="HBH2091171.1"
                     /translation="MAGAGIKAIKTRMGTVESTKQITKAMELVASSKLRKAKEKAEDS
                     REYFNTLYNTVKDIAQTTRGIRNEFLKEREVKNKCYVVVAGDRGLAGGYNSNVLKESV
                     SHMKGKKETVITVGKKAHEFFSKRNYNIAKDINSVEACGYEDATEISQTIIDLYKKGE
                     VDEVYIAYTKFKSALSQEVEILKLLPLVFEKDTDEQGMAVKEEKQNRSKVQYIPSAEA
                     VLSYIVPQFISGTVYGGILESFASEQGARRTAMESATDNANEMLSNLELSYNRARQSA
                     VTQEITEIVGGVEALK"
     gene            77973..79367
                     /gene="atpD"
                     /locus_tag="KRO40_000329"
     CDS             77973..79367
                     /gene="atpD"
                     /locus_tag="KRO40_000329"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HBH2091172.1"
                     /translation="MANVGKVVQIVGAVLDVKFDGEQSLPNLLNALVIKLGDKEIVAE
                     VAQHIGDDTVRCIAMSATDGLVRGMEVVDTGGPISVPVGDETLGRIFNVLGKPVDGKP
                     APKSAPKLPIHRPAPAYDELETTAEILETGIKVVDLLAPYLKGGKIGLFGGAGVGKTV
                     LIQELINNIAKQHGGISVFSGVGERTREGNDLYGEMSESGVINKTALVFGQMNEPPGA
                     RMRVALTGLTMAEHFRDEQGQDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLA
                     TEMGALQERITSTKKGSITSVQAVYVPADDLTDPAPATTFSHLDAKTVLSRQISSLGI
                     YPAVDPLESTSRILDPSIVGKEHYEVARGVQSILQRYKELQDIIAILGMDELSDEDKL
                     IVARARKIQRFLSQSFTVAEQFTGNPGQYVPVKETVRGFKEILEGKHDDLPESAFLFV
                     GTIEDAVRKAKGSM"
     gene            79370..79630
                     /gene="atpC"
                     /locus_tag="KRO40_000330"
     CDS             79370..79630
                     /gene="atpC"
                     /locus_tag="KRO40_000330"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit epsilon"
                     /protein_id="HBH2091173.1"
                     /translation="MASEFSLKVVTPSNTFYDGDVEMIVVRTTKGDKGVLKGHIPFVS
                     GIPVGTLKIKKEGSFKEAKIAEGFINVTQDKTVILTESAEWI"
BASE COUNT        32198 a         8406 c        14339 g        25005 t
ORIGIN      
        1 ctagcattat aagactataa attgaaaata ttcagaaaaa tactacaaga aacgatttat
       61 tttgctctta aaataagtta aatgaatgtt attaattttg taaattgaaa tagtttaagt
      121 ataaagttat gatataatct aataagggta attctttaga ttatattaag gaaatatagg
      181 tatacaataa aaagttatgg agttggatta tgggatataa attaattgta acagatatgg
      241 atggaacttt attaggcaat aatcataaag ttacagatga aaataaaact gcactacaaa
      301 aagttataaa aagcggtatt aatgtaactt tagcaacagg aagagccttc gattcagcta
      361 aatgcaatgt agattttctt aaagaggaca tgccaataat agcttgtaat ggttcattaa
      421 taagagagca aaatggaaac ataatatatt caaataagat tgatacaaga acatgtttaa
      481 acattttaga tgtattagat aaatacgata tttactacca atgtaatagt atagattcta
      541 tgctttcgaa aaaaatagaa ggacgtgaag atagattaag tgtattttta ggctctgaaa
      601 cagaagtaat tgtaaaagat gatttgagag aagaaatctt taaaaaagat atactaaaat
      661 ttgtaatcat agaagaaaaa aatccatcta ttttggatga aataagaaaa gaattgagaa
      721 aagttcaagg aataaagata acttcttcat ggccaaacaa tattgaagtc atgaatgaag
      781 gtgttgataa aggtaatgca gttaaaattt tagctgaaaa aatgaatata gacagagaag
      841 atataattgc atttggagac aattacaatg acatagaaat gataaagttt gctggtcttg
      901 gggtagctat gggaaatgca gaagaattga ttaaacaaga agctgattat gttacagata
      961 caaatcaaga cagtggagtt gcaaaggcaa tttataaatt cctagagtta aaagaatcac
     1021 ttagctctta aaacagtata taataggaaa aaataggttg actattttgt agatagtaat
     1081 tataatacaa atagataaaa cataaaaatt tagattcagt gaaaaagaga gtagatatag
     1141 agaaaatctc agcgaattgg gggatggtgt gagcctaatg ataacacttt atattgaaaa
     1201 gaactttgga gaatactact tgaaattcag tatggtagta ggtaatctcg ccttaagaga
     1261 atagagtggg taaacattgt ttaccaacta gagtggtaac acggaatatt tcgtctcttg
     1321 gtctttttga ccaagagatt ttttagtttc attgagttac aagacttata attaaaatac
     1381 aaaaaattaa aatatgaggt gaaagttatg aaattatggg gcggacgctt tagaaaagcg
     1441 gaaaatcaac ttatggaaga atttaataaa tcttttggct atgattgtgt actgtacaaa
     1501 aaagatatcg aaggaagtgt agcacatgtt catatgcaag taaaatgtgg acttttaaca
     1561 gaagaagaag gaaagtctat aacagaaggt ttaaaaggga tacttgaaga tgtagaaaat
     1621 ggaaagttag tattggatgg agagtatgaa gatatacata gttttactga gataaattta
     1681 attcaaagaa ttggagatgt tggcaagaag cttcatacag cacgtagtag aaatgaccaa
     1741 gttgcagttg atatgagatt gtatgctaaa gaaaaagcaa atgatttggt gggtttaata
     1801 tctgaattta aagctactat aaaagatgtt gctgacaaaa acccagtgat gatgccgggc
     1861 tatactcatc ttcaaagggc acaagtagtg acatttaagc atcacttaat ggcatattat
     1921 agtatgtttg atagagatga gaaaagaata aaaaatgcta tagaaatatt agatgaatca
     1981 cctttaggct gtggagcttt agcaggaact acgcatgata tagatagaag tataacttgt
     2041 gaacaattag gatttaaaaa agtagtagat aattttatgg atggagtaag tgatagagat
     2101 tatttactag agctaatgag tgatttttca attataatga tgcacttaag tagattaagt
     2161 gaagagttga tactttggag ttctcaagaa tttggatttg ttgagataga tgatttatat
     2221 acaactggaa gtagtataat gcctcagaag aaaaatccag atggtgcaga gcttataaga
     2281 ggtaagactg gtagagtata tggaaactta tttggtcttt ttacagtaat gaaaggaata
     2341 ccattagcat ataataaaga catgcaagaa gataaagaag gttttttcga tagtgtacat
     2401 actcttgaaa tgtgtataca aataatggat agaatgatag ccacactaaa ggtaaatgag
     2461 gataaaatga aacaagcagt aaaaaatggt tttttaaatg caacagaagt tgcggattat
     2521 ttggttaaaa ataatgttgc ttttagagat gcacatggta tagtaggaag tatcgttata
     2581 tattgtgaag ataataaaaa agcaatagaa gatttaacat tagaagaatt acaaaagttt
     2641 tcagatgctt ttaaggaaga tatttatgat tttatcgact atgagagtat attaaataag
     2701 ggaataaaaa agaatttaaa ataatgtatt tatttttaaa agctgtaaat ttgaatgtta
     2761 tcatttaaat ttacagcttt ttattgtgta agattttatt atataaaagt aagaaactta
     2821 aaaggagtag tatttaaaat aaatacaaat aaaaaattat tattaaaatg ataattaata
     2881 tcaataagta ttgacaaaat tatttctaaa tactattata tataatataa ataataatga
     2941 aaatcaatat caaataaatg ggaggaaatc taatgaactt attagtgatt ggtggtcatg
     3001 aaagaatgga aaaagattat atggttatgg ccaagaaaaa aggttataag acaaaggtat
     3061 atactaccat gtcatctaaa ttaaataatt ctataggaag accagatgca gttgtcatac
     3121 ttacatcaac tgtttcacat aagatgtcta gaacggttga gtctcaagct aaaaaacaag
     3181 atatattaat cgtaaggcat aaaaatagta gtaaggtagc atttaatgaa tgtctagata
     3241 tggttgatga atgtctggga aattgttcaa aatgtaagct taaagacaaa caaaaacaaa
     3301 aaaatatata ggtataaaaa atacataaac ataaaattaa aagtactgag ataatagtta
     3361 taattattat ctcagtactt ttagatttat aaggataagt atagtataaa ttttttatta
     3421 taatttccaa ctacttgtta ctttttcata ttttttttac ttctagcttt ttttcttttt
     3481 ttcttcttta tatttgaagc tattataaat aaaactaaaa gcactagaat acctgcaata
     3541 atcttaacaa aagtcattaa aacattattt tcagtcaaaa atggaagact gctatcaaga
     3601 ttattttttg caattaagtc tatactgttt tctagtttac cattattata tacatttaaa
     3661 gtaccaacct tagccccttt ttttataggc aaatcaattt tatttaactc tgttttggta
     3721 tcataattgc cttgagattc atctttttct aagaatatcc tataactatt ttttggttca
     3781 taaatcaatt catgttgttt tgtaaacaat acttttttag tatctgtgta tttttcttta
     3841 tcaacaatag tagcacactt aaagttatca aatccataat caatcagaat acgtgagtct
     3901 aaatataaat cagcattagt tgaattaaat acagcaacga taactcttct gccatctttt
     3961 acagcactcg ataaaagaca tttaccagca gcatcagtat atccagtttt tataccatca
     4021 actatatcat attttatatt tataggttga cctttgtatg taatcttatc atgtgatgtc
     4081 aaaaacttat tagtgtttac aaagtatctc tcataaggat atgcttttgt agcttcaaat
     4141 ttaagtgact tagtttttac aatttgtcta aaagtatcat tattcatagc ttctctagct
     4201 atgagagcca tatcatgagc tgttgtgtag tgatttgggt ctggtaatcc atgaggatta
     4261 ttaaaatgag tattagtagc tccaattttt tttgcctcag agttcataag gtcaataaat
     4321 ttttgtacat tgccaccacc aacatatcta gctaatacaa aagcagcatc attagcagaa
     4381 tgaaccaaaa gagcatctag taactgcttt acagtaaaag attccccatt ttttagatac
     4441 atactagaac catctatttg aggtaaatct ttaatttcta ttacttgatt taaatcttta
     4501 acctccttta gaactaaaca agctgtccat actttagttg ttgaagctgg ataaagctta
     4561 gaatttccat ccttattata tagtattttg ccagactcat agtccattaa aactgcatgt
     4621 ttagcaacta tagctggttc attatctgca aaagagatat tagagcttcc taaaaatgaa
     4681 gtaaatatca ataaacagat taataaaagt gataaatttc ttttcattgt gagcctccaa
     4741 attttaaatt catcttttag tatagcatat atttgtcaat aattaaaaga aaggagtgat
     4801 taatatatga aaaaaaaggt aaaatttatt tcgttttttg ttttatttat tttaataata
     4861 tcatcaataa tcgtttataa atcgcttatt ttcaaagatg atatttatgt tgtaagtaaa
     4921 aaaaatttac ctaatgaaaa aacacatgtt gtagagaatg aaattaaagg tgaagataat
     4981 aatcacagta aagtaactaa agacatagat aaaaattttc aaaataataa aataactata
     5041 tacataagtg gagcagtaaa tagacctgga attgtaacta tagagtcaga caagagactt
     5101 tatgatgctg tagaattact aggaggaacg acaaaagaag cagatttaaa tggagtcaat
     5161 ctatcagtaa gattagaaga tgaacaacat tacataatac ctaaaatagg tgaagcaaca
     5221 tctgttacaa gtaatgatga ttccaataaa ccaaatcaga agaatgagtc aagaggtgag
     5281 cctaaaaata aatccaataa aaatatatct aacgaatcaa aagtaaatat aaatgtagcg
     5341 actatagaag agttggattc tctacctggg gttggagaag ctacagccaa taaaatttta
     5401 caacacagag aagaaaatgg acagtttagt tcaattgagg aaataaaaaa tgtaaatggt
     5461 attggagata aaaagtatga aaatataaaa gatttaattt gtgtagacta aaatataata
     5521 caaaacttac atatagatat gttattataa atatgtatgt atatgtgtgt acatgtggaa
     5581 atttagtaaa ggaggcactt ttatgaaaaa agaacaaaaa aaacttacag agatgacaac
     5641 agcaggtggt tgagccgcta aaatagggcc agaggttctg gcatcagttt tatctcaatt
     5701 gcctaaaaat gataatatag aaaatttatt agtaggacta gatacagcag atgatgctgc
     5761 agtttataaa ttaaatgatg atatggcact tatccaaact ttagacttct ttacaccaat
     5821 ggtagatgac ccatacgtat ttggtcaaat tgctgcatca aattcactat cagatgtata
     5881 tgctatggga ggcaaacctt tggttgctat gaatattgtt tgttttccat catgccatga
     5941 tatggatgta cttgcagaaa tattaaaagg tgggtttgat aaagtgaaag aaagtggagc
     6001 acttttggtt ggagggcata ctgtagatga caaagagcct aaatatggtc tttcagtttc
     6061 tgggattgta agtccaaata aagttttatc aaatgctact gcaaaacctg gtgataagtt
     6121 aattataaca aaaccaattg gagtgggtgt attaaataca gccatgaaag aaggtatggt
     6181 agaacaacat atagcagata aagtaataga aataatgata catttaaata aatatgcagc
     6241 aatgagtttt gagaaatttg atgtaaattc ggttacagat ataactggtt ttggtctact
     6301 tggtcatact ttagaaatgg ccaaagcttc tgaagtaagt attgaaattg aatcaaaaca
     6361 tgtaccaatt attgaaggtg caatagaaat ggcacaaatg ggaattatac ctgctggtat
     6421 gtataaaaat atgcattatg tatctaaaga tgtagaagtt gtaggaaata tagaagttgc
     6481 agttcaagat attttatacg acccacaaac atcaggaggg ttgttaattt cagtaaaaga
     6541 agaacttgca gaggagcttg taaaagatat gaaattaaat ggagcaatag aagctaaaat
     6601 tataggttct gtagttccaa aaggggaaaa atatattaca gttttataaa atattataga
     6661 gaaagagtga ttgttttgag caaaagagaa ttgtttgcaa tgttgccttc agttgatgaa
     6721 gtattaagtg ataatagaat tgtagaaata ataaatgaat atcctagaag tttagtttta
     6781 gaatctgtga gagaagtaat agatttaaaa agacaattta tattaagatt aaaagaagat
     6841 gcatcaaact ctgtaacaat agagtttggt gaaataatag aatctgcaat agagagagtt
     6901 aagttaaatt actcattatc tttaaaaaaa gttataaatg caactggtac agttattcat
     6961 acaaatttag gaaggtcttt acttagtgaa gatataaaag atgaattatg gtgtgctgct
     7021 tcaaggtatt caaacttaga atacgatttg gataatggag aaagaggttc aagatactct
     7081 catttaacta gtacaataaa aagacttact ggagcagaag atgtactagt tgtaaataat
     7141 aatgcagcgg cagtacttct tgtacttagc acaatggcta aaggaggaga agcaattgta
     7201 tctcgtggag aattagttga agtaggtggt tcatttagga ttccaagtat aatggctctt
     7261 agtggtgcag aattagttga agttggttca actaataaaa ctcatttgaa agattacaag
     7321 gaggccatta cagaagatac aaatgtattg atgaaggttc atacaagtaa ttatagaata
     7381 atgggattca cagagagtgt ttctatagaa gaattggtta atttaggtaa aaaatataaa
     7441 ctacctgtaa tagaagactt aggaagtgga gtttttatag atttatcaaa atatggttta
     7501 tcttatgaac caactgtatt ggattctatt cgacaaggtg cagatgtagt aacttttagt
     7561 ggagataaga tgcttggagg tccacaagca ggtattatag ttgggaaaaa agagtatata
     7621 gaaaaaatga agaaaaatca acttactaga gcacttagag ttgataagct tacaatatgt
     7681 gctcttgaag caacattgag aatgtattta gatgagacaa aagctataga aaatatacct
     7741 actttaaaaa tgttgacata taaaattgaa gaattagaag taaaagcaaa taaactattt
     7801 gaaaaaataa ctgctttaaa cttaaatgca aacataaata tagaagatgg attttcacag
     7861 gtgggaggag ggtctatgcc tcttgaaact ataagtacaa aggtaatatc aataactcct
     7921 gaacatatga atgtttcatc tttagaaaaa aaactaagac ttagtgaagc acatataata
     7981 gccagagtgt atgataataa atatgtacta gatgtaagaa ctatatttga tgatgaattt
     8041 gatgtaatag ttgaggaatt gagaaaagca tttaattaaa taaatttgag ttaataaata
     8101 ttaaatttag aagtataagt atgaagtttt gattaaaaaa tagctacaca cacttgtgac
     8161 tttagtcata gcaggtttag agggggcaaa aaatgaaaaa tgtagtaatt ggaacagcag
     8221 gtcatattga ccacggaaaa actactctta taaaagcatt gactggaaga gagactgata
     8281 cgttagatga agaaaaaaag agaggtattt caataaactt aggatttact tattttgatt
     8341 taccaaacaa tagaagagct ggaattgttg atgtcccagg acacgaaaaa tttataaaaa
     8401 acatgttagc tggagcatca ggaattgata tagttttact tgttgtagca gcagatgaag
     8461 gggttatgcc acagacagtt gagcatttag atattctaag ctttttaaat atcaaaaatg
     8521 gaatagtggt tctaactaag tctgatactg tagatgatga atttagagag ctagtaaaag
     8581 aagatatttg tgaaaaaata aaaggaactt ttcttgaaga tgctgaaata attgaagttg
     8641 attctatatc taaaagaggt atagacactc ttattgaaaa aatagataaa atgagtgatg
     8701 atatagaaga taaaaatgaa aactctccag caagacttaa tatagacaga gtattttcaa
     8761 taaaagggtt tggtactgta ataacaggca ctttaataga aggaaagata agtatagaag
     8821 atgatttggt tatatatcca caggtattaa aaacaaaaat aagaagtata caagttcatg
     8881 gagaaaataa agatacagct tatgcaggtc aaagaacagc aatcaatata tcaaatgtaa
     8941 aagtggatga tataaaaaga ggagatgttt tagctgcacc aaactcattg gaggaatcaa
     9001 tgatgttaga tgtaaaatta tcattggtaa atcatttaga taaaggatta aagcactggg
     9061 atagattaag attgtatcat ggaactagag agatactttg tagagcagtt ccactagata
     9121 aagaattaat tgaaagtgga gaaagtggct atgttcagtt gagacttgaa gaaagcatag
     9181 tatctaagaa aggtgatacg tttgtagtga gacgttattc tccaatggaa actataggtg
     9241 gaggtgtaat aattgaccca tctcctaaaa aacataagaa atttgatgaa aaagttatag
     9301 aagcattaaa aataaaagaa aaaggcgaac taaaagatat aatagaagag tacttaaaaa
     9361 ggaatttaaa aaattatcca aatataaaag aaataatgag ctatagtggt gctcatgaag
     9421 aagatgtaaa aagagcgctt gaaacactta tatcagaaga taaagtattt attataggaa
     9481 atatgtatat gcatataaat caatacaata aattaaaaga aaatacaata aagcttttaa
     9541 gtgagtacca taagaagtat aggcttagaa aagggatact aaaagaagaa gtaaggtcta
     9601 agatagagag taattttaag actagggaga tggatatttt attagaaaaa ttgtctacag
     9661 aaaatgctat aaaaatagaa aataatatag tatctctatt agattttgag gttattttaa
     9721 atgataagca aaaagaaata gcaaaaaaaa tagaaaaaag attaaaatca tgtggagttt
     9781 cttctatact gacaatagat gaagtttctg aaggaaatca taactatgct gaagtattgg
     9841 agtcaatgat aggtaataaa gtagagaaat tagatgattt gtatataatg gacaaagata
     9901 tttatgaaaa tgcaaagaac attttgataa attatataaa agaaaataaa gaaataacat
     9961 taggagaata cagagatttg attgattcta gcagaaagaa ttgcatgatt atattggaaa
    10021 acttcgatag aaacaaaata actaaaagag tagaaaacaa aagaattttg ttttagtaga
    10081 aaatgtctgt ttttgcttta aggtataaag aaggaattat aatgtcgagt atcgtataat
    10141 taattagtat aaaatattaa ttaagaggaa gtgtaaagta ttgaagaata taatacctga
    10201 tgtaaaacca gatataaaag aaagagaaga catgagcctt ttatttataa taatgggctc
    10261 agtactttta ttatttatta taaaagatat agagaaatat gaaactttat tacatgccat
    10321 atatacgata tttttagtag ctacaggagt aattatattt aatactacaa aatttaaagt
    10381 agattcattt tctacatttt taggattaat ttttatagct actggagtat tggagtgtat
    10441 atatttattt aattccttgg ggattaaaac taagtctata atggagatta acatcacaat
    10501 atcagcaata acagatttat ttcctatact gggtgtatac ttaagtttta aatttgttaa
    10561 ggataacaaa caaatttatt caagtgtaat tttatttata gcaactgcta cattaacaat
    10621 aacatcttta ttcataatat caggaatttg tgactatctg ggaaatggta aatcacaata
    10681 tgctttagga gttataatat ctatattcat aataattatt tctatcgtta gtggaattga
    10741 attaaattca agttcaaata aaggtaaatg ggaatatgat gaaaaaaaga tttttaacag
    10801 aataatagta ataataatct tatcaagagt tccaaatcta ttgcatatag ttattgataa
    10861 tagaaatgta gagaggatat tatcacaaat aataataaat gtagccttat attatttata
    10921 taattacata gtatctaaga atattaagaa aacagcactg gaattgcatg atacgaatga
    10981 agaattaaca aaaaaaacgg aaagtttaaa agaaaagaat aaaaaattaa tctatgagac
    11041 agaaaagata gaggaactta agggaatact tatgaaaaga gaatctaggc tacaatctac
    11101 attagatgta gcagtaaata gcatagtagt atttagcaaa gatggagaaa ttacatatgc
    11161 aaataagagc tttagaaata cttttggaga ctataaagaa caagataaat tgactgataa
    11221 aataaaaaac ttcaatgatt tgatagaaag cattcattat gtgtttgttc atgagaagaa
    11281 tgcagagaaa cttattagta caagcgataa taaagtttat caagctatat ttgcaccttt
    11341 aattattgct tcacaaacag aaggagtatt gtgtgtacta gaagataaga ctaagaaaaa
    11401 ggagtacgaa cgcaaactta ttgaagcaaa taagagaagt aaagattttt tagaaagtat
    11461 tggagatggc atagtagtgc ttgaaggtaa taacaaaata tatgttaata atgcatgtag
    11521 ggaaattttt aaaaataatt tagagagtat tgatttttca ttagtatgta aaagtgaaga
    11581 aagtatagaa aaaagatatg taatagatgg tgaagtaaag tatgtagaga tgagtttttc
    11641 tcagtatact aatgctggta ctaataaaac tattattgta atacgtgata caacctctcg
    11701 aaaaatatct caaataaaac ttgaggaaag tcaatcatca tattcaagat ttatagatat
    11761 attacctgat ggcatatgct tattaaaaga agatttaagt ataaactatg caaataagtc
    11821 gtttttagat atgctagctt ttacaaacat agatgatata aaagattcta atattaaact
    11881 attaatgaat gcgaatactg aagaaaaaat gaaatttacg gataatatgg ctaaagtttt
    11941 aaatgaaaat agaagtatac ttttactgga atatgaattg ataaatagtt atgatgatat
    12001 agtagaagta gaattaagtg cattaccttt tgctatatac aatactagat acataatgct
    12061 tattataaaa gatttagtac ataagaaata ttccgagcaa gcagaaaaag aactgcttga
    12121 aagatttaaa acagataaaa tcaaaacgga gttttttgca aatatgtctc atgaactaaa
    12181 aactccacta aatgttatat ctagttcaaa tcaactggta gattctttct atagaaatga
    12241 aaagataaaa gattacaata acaatattaa atctcatgtg gatttagtta gacaaagttc
    12301 ttataggctt caaagattaa taaataacat tatagattta acaaagatgg agtctgggtt
    12361 ctatacacta aaacttgcga aatacaatat tgtatctgta atagaagact tatttatgaa
    12421 tatagaagag tatgcactta gaaaagacat aaaaattctt tttgatacag accttgaaga
    12481 aattaatgtt tatatagaca aggttgaaat tgagagaatt atgttgaatc tattgtcaaa
    12541 ctgtattaag tttactgata atggaggctg gatatatgta agtattcatt ataaaataga
    12601 taaagtaatc ataagtgtaa aagacactgg agttggaata ccacaagata aattagagtt
    12661 gatttttgaa gaattttcac aagttgataa gactttatcc agaaatactg aaggaagtgg
    12721 aatagggctt gctatagtta agaatctagt aagtcttcat ggtggagata tagaagtagt
    12781 aagtgaagtg aataaaggca cagagttctt aatttcactt ccaatgaagg gatttagtag
    12841 tgaacattac acagaagata agagaatata taatattcaa gaaaaaataa aaatagaatt
    12901 ttctgatata tattattaaa aatgattatg agcaaaaata aaataaaaat actatttgtt
    12961 taaatattta agttgtaaga aataggctat cataaggtaa attattatga tagcctattt
    13021 ttagctaggt tttatatcta tatgtgagaa catataatct ctaaattacc ttcaaaacta
    13081 aaatctccaa agtcgtttgg tagtataaaa tgcataccct tttttaaatt gtattctaca
    13141 gaattgtgta taagttttcc atttccatcc aacacactgt ataaagaaaa aggtgtattg
    13201 tgtgtaaaat tacattttcc aaaaacatct aatttataaa cactaaaaaa ttcgtttgac
    13261 acaaatgttg tgcatttaaa gtctgatgtt gatacgattt tatagtcagt atcgaaattt
    13321 atatgaggaa cattcgtaac atctattgat ttttgaacat gaagttcacg cttattacct
    13381 gaattgtcag ttctatcata atcatagact ctataagtag tatctgagtt ttgttgagtt
    13441 tctaaaatca atgttccttt gcatatagca tgtatagtgc cacttggaac atagaaaaag
    13501 tctccctttt ttatattaac ctttctaagt agtttgtccc attcattatt atttaccata
    13561 tttacaaatt ctttatgaga ttttgcatta tgacctatta taatttctgc atcatcagaa
    13621 caatctatta cataccaaca ctctgtctta cctaactctc cattttcatt ttttttagca
    13681 tattcatcat ttggatgaac ttgaactgat aaattatcat ttgcatccaa tatttttgta
    13741 agtaaaggaa acttatcacc aggtgtgttt ccaaataatt ctctattttt attccacaat
    13801 tcagatagtt ttttaccttt atattttcca ttttctatta agcaatctcc atttttatga
    13861 gagcttatag cccaacattc accagttgtt ggcgaatcta tttcataatt aaatttatct
    13921 ttaagtgcag taccacccca tattctatcc ataaaaatag gttttaaaaa taatggttcc
    13981 ataatcctgt tcctcctatg atattaaatt tatcctacaa ataattatat ataaatagat
    14041 tataaaatca atagtaaaaa agttttgtcc cttgaaatga cataaagtat aaggagttat
    14101 taaataagat aaactatgat atataatata aagttctaaa ttggagtgat aattatggag
    14161 ttgtttaagg cagaaagcaa aaaatataaa aaagaatttt taaaattatt ggagcaatgg
    14221 gttagtatac cttcatttta tgatagaaaa actgtatcta aagacatgcc ttttggaaaa
    14281 ggagtatatg atgcattaaa ctggtttgaa aatctaggta gagaaaacaa tttcaaagta
    14341 aaaaatatag ataatcatgc tgttcaaatt gaatatggaa atggtaaaga gtatgtagat
    14401 atatttggac attgtgatgt tgtaaatcca ggtgaaggat gggatagtga accatttaaa
    14461 ctaaatatta taggtgataa attagttgct agaggtgtat ctgataataa agggcctatg
    14521 atagtgaatt ttttagcact aaaaatgata aaggatttag atattaattt aaaaagaaag
    14581 gttagattaa tagctggggg aaatgaagag agtggattta aatgtataaa gcattattat
    14641 agcaaagagc catatggtgt atgtggattt actccagatg ctaaatttcc tgtattaaat
    14701 ggagaaaaag gtggagcaat aataaagtta atttcaaata tagacgataa atctttatat
    14761 ataagtggtg gaatagagtt taatacaata ccagataaag tttatataaa gaatgtagaa
    14821 aaattgggta aagataatat atgttttgat attaacaata tatcgataaa ttatgataat
    14881 ggcaattata ttgtgtatgg aaaaggtggt cattcatcta aacccgaaaa atcaataaat
    14941 cctatattag ctacaattaa acttttgtca gaaaatattg atgaaaaatg gacaaaagat
    15001 ttatataagt tgataaatca agataatata aatggaaact tatttggttt aaatattgag
    15061 gggaaatgtg gaattttatc aatggtgcca acaataataa atatagtaga tggaaaatta
    15121 gaagtagttt taagcgttag atatccagaa atattaacca ttgaagatat aataaaaaaa
    15181 tttaatttgt atatggagca aaataatatt aataaatttg agcttattgg ggaaaattta
    15241 aagcaagcaa attatataga tagaaattca aaacttgtaa gaagtttgca tgatatatat
    15301 ataaagtatt ctggagattt aaaaaatgat gttagagtaa ctagtgcagg aagttatgct
    15361 tctgaaatga ataattcagt aatatttggt tgtgaatttc ctgatggtag ctttggcaat
    15421 gtccatagtg cgaatgaatt tgctagctta gatagattta taactgcaat aggtatatat
    15481 gcagaggcaa taattacatt atgtaataaa atataaatac aaaatgtccc ttatatagac
    15541 atattatata tacaattaaa attttacttg atatataatt gaaatcaaag agaaggtgat
    15601 acaatgataa ctaagaaaca tgcaataata gtaaagagtt taagcaataa agatggatat
    15661 atgacatcaa acgaattagc tatcaaattg gatgtgtcta ctaaaactat taaaagatat
    15721 atagcagatt taaatagtgt tttaagcaaa tatgatttgg taatagcttc ttctagaggt
    15781 ataggataca agttaagcgg ttctaaaaac aatatagcca gagctgttaa agaagcaaat
    15841 aaatatattg atggtttttt agatgactct gaagagtcaa gaatgtcaaa tataatatgt
    15901 atgcttatta atagaaatta tatgagtata gaagcaatgg cagaagaatt aaatctaagt
    15961 atagccgcta taaataaatt gtctagtaag cttaaaagaa aacttgaaaa gtatgactta
    16021 gttataaaat ctaaacctta ctatggaagc tatatacatg gtgaagaaat taatataagg
    16081 caattaatta ctgactatgc aataaaatta gatgaaaaaa gtaaagtgaa ggtgttttta
    16141 gatgacatta gtgaaaacga tatacactgt atagaaagta ttttagaaaa gcacttaaga
    16201 gaaaaagata caataatttc agataaagat tttaatcttt tgctttcaaa aataatcgtt
    16261 tctgtattta ggagtaagag aggtcatagt aacaatataa acttaatgga tacaagttat
    16321 agatttcata actactactt tatagaaaat ctaatgaaag aaatatctga taaaattgga
    16381 tttaaactta ttgaagatga agtaatttat atttcaaatt attctggtgt aatagcctat
    16441 aaaggtacac aaggaagaaa aaacacaagt gaaattgagg aacgaataag tactgttata
    16501 agtagtgcac ttcaagatat attccttatt tcaggtagtg attatacaaa agatgatgag
    16561 tttatggttg caatctctga ccatataaag agatttttaa atagagctag agctaatgta
    16621 aaatcaaata atcctttact tcatcaaata aaagagaagt ttcctatagc ttttaattta
    16681 gccgtgtttt tatcaaataa actagaaact gagtttaatt taaaacttga tgaagatgag
    16741 cttggatata tagctatcca ctttgctgct tcaaatgaaa gaatgaaaaa aaatactagt
    16801 aagaaaattt gtatagtttg tcattatggg ataggaacag gacaacttat ttctgaaaag
    16861 ctaaaacaga atataagtga tttaagtgtt gtgggtgttt atccagttag atatctcgat
    16921 atggctataa gtcaagatgt tgatttgata gtatctaccg ttgaattaaa aggatatgaa
    16981 aaacctgtct tatatataga aaatatattt gatgatagct taattgaaaa cgtaaacaaa
    17041 gccttttatg aaaaggaaga aagaagaaag ataataagca acatgtttga tgaaaaagct
    17101 tttttcagta taaaggctaa tactaaagaa gaggtcataa tttcactttc aaataaacta
    17161 aaagaaagag attttataga ggaaagttct ataaaaagta taatagatag agaaaatatt
    17221 tcatcaactg aaataggaaa tctagtagca ataccccaca caatagtgaa gggagataaa
    17281 aaatctataa taggagttgg aatacttgaa aatccaataa tttgggataa gcaagaggtt
    17341 cagctagtat ttatggtatt ttttaatact aaagaaaaac ataatttctc gatatttaaa
    17401 tacctttata attttataaa agatgaaggc ggagtaagag gaattattaa aatatgtgac
    17461 tttaataaat taatggcact gataggtaat taaggaggaa attaataatg ggaacaaaca
    17521 tatttaacaa agaatatgta tttttaaatg ttgatgctaa gtcaaaggtt gaagttttaa
    17581 aatttatatc aaaaaaagct aaagacttaa acttggcaga agatgagagc ttagtatatg
    17641 aaggtttaat ggctagagaa gaacaattta ctacaaattt aggagaatct atagcaatac
    17701 ctcacactaa aaatgatgca attgaaaatc cagcagtagt agtattgaag tttaatgaag
    17761 atgttgtttg gaatgaaggt gaggataagg ttaaattagc aataagctta cttatgccag
    17821 gaaaaagtaa agagaatatt catcttaaat tattatcatc tctttcaaga aaattaataa
    17881 ataaagaatt taaagattct cttttaaaaa gtgataatgt tgaagaaata tctaacttaa
    17941 taaatgaagc tttaggttta taattaaaca ctaaggttat aaaataaaaa aataattaac
    18001 taaaaatagg aggaatttga aatgaataaa aaattagtag cattatgtgc ttgtccaatg
    18061 ggactagctc acactttcat ggcagcagaa gcaatagagc aagcagcaaa ggcattaggt
    18121 tatgaagcaa aagttgaaac tcaaggtgct gatggtgtac aaaatgagtt aacaagagat
    18181 gatatattag gagcaactat gataatacat gcagtagcaa taacaccaga aggtatggaa
    18241 agatttgatg gttgtgaagt ttatgaagtt gaattacaag aagctataaa aaatgcagaa
    18301 ggtgttataa aagaaataga agaagattta ggaatataat aaatttattg tggaggaaat
    18361 agaatggcaa ttaagaaaaa agttataaac agttcaggtg cttctacaac aggaggaaat
    18421 aatgtaggaa aatctactcc atctagtcca actcaatcaa agggaaatgg aaaatggaaa
    18481 gaaataagta aacatataat gacaggtata tcatatatga taccagtttt agtaatgggt
    18541 ggacttatag gggccttatc tcaattaata ccatatgcta tattaggact tgacccatct
    18601 gtaggtatag ttgatgctat gaactcagga gaatttacag ggttcaagct tagtctttta
    18661 aatatagcac aattaatgtc aaatttcgga tttactttgt ttggatttgc gataccactg
    18721 tttgcagcat tttgtgcaaa ctctataggt ggaaaaacag ctttaattgc aggatttata
    18781 ggtggatata tagctaataa acctgtaggt gtaccacaat tcgttgatgg acaatggact
    18841 gaagttgttc cagttgcatc aggattttta ggtgcaatac taatagcatt tataatagga
    18901 tattttgtaa aatggttaaa taaatctata aaagtttctc ataactggtt agcttttaaa
    18961 acaacatttt taataccatt aatagcgtca ttagcttgta tggtattgat gatatttata
    19021 ataactccat ttggtggatt aattaatgaa agtatgaaaa acttcttaac agcagcagga
    19081 gcagctggag aatatgtata tgcaacagct ttggcagcag ctacagcatt cgacttagga
    19141 ggaccaataa ataaagcagc aggattcgtt gcacttggtt taactacaga gaatgtactt
    19201 ccaataacag caagaacaat agctatagtt gttcctccaa ttggattagg attaacaaca
    19261 ttattagata aaagattagt aggaagaaga gtatatgata gacaattcta tcaagcagga
    19321 aaaacttcta tattcttatc atttatgggt atatctgaag gagcaatacc atttgcactt
    19381 gagagaccag gttttgttat acctttaaac atagttggaa gtgtaatagg agctattaca
    19441 ggtataattc taggagcaat tcaatggttc ccagagtcag ctatatgggc atggcctcta
    19501 gtagataact tatttggata tataataggt atagcagttg gtgctatatt catagcagta
    19561 ggaaatatat tctatagaaa taaattaata aaagatggta aacttgttgt agattatatc
    19621 gactagtatt taatttttac tatctataaa taactttggc tggtaatatg gttttaatca
    19681 atattaccag ccttacctat atgattaatt aaaggcggtg gagataagat atggataaga
    19741 tagaaaaagt aagagagtat tttagagaat atgatataga tggatttctt ataaatagtc
    19801 ctacaaacaa gttttatgtt ggaaatttat ttagctcttc aggttatgtt tttataacta
    19861 aagaatcaca atatataata gtagatttta gatattttga agaaattaaa agaaaatcta
    19921 gtttgtttaa tgtagtatta atggacaaaa ctagaactca ttttgatata attaatgata
    19981 tttgtagaga gcagaatata aaggaaattg gatttgaggg aaatgaagta tcttttgatt
    20041 tatatagaag tatgagtaat aagttaagtg caaccttaaa atcagttgat ttatctacat
    20101 taagggaaac aaaaaatgaa gacgaaataa aatatataaa aaaagcttgt gaaatagttg
    20161 atgctacatt ttatcatata gtagacttta taaaggttgg tatgactgaa aagcaagttg
    20221 aaaatgaaat tgttagaatt ataaaagatt taggtggtca aaaagaatct ttcgatacaa
    20281 tagttgcatc tgggcttaga ggagcattac ctcatggaaa agcaagtgaa aaagttatag
    20341 agtatggaga ttttgttacc tttgactttg gtgctaagta taataattat tgttcagata
    20401 ttaccagaac catttgtatg ggtactataa ataaagagtt agaagaaata tataatatag
    20461 taagaaaagc taatgaagag tgtataaggg ttttaagacc gggaatgact actggagaga
    20521 tagataaagt tgcaagagac ataattggtt catatggata tgccaataat tttggtcata
    20581 atctgggtca tggtgtagga attatggttc atgaatatcc tgcattagct cctgaatcaa
    20641 atgaagtatt aaaagaagga atgattgtaa ctatagagcc tggtatatat gttccaagtc
    20701 ttggaggcgt aagaatagaa gatgatgtac ttataacaca agatggatgt atgagattga
    20761 ctacatctac taaggattta atagttgtaa gctaaaaata aattagataa atattttata
    20821 acaataagaa aagaagaggt aaatttaaat gtataatttt gatgataaac cagatagagt
    20881 aagtgaaaag tgtagaaaat gggatttaaa tattataaga gataaatttg gagatattag
    20941 agaagatttt ataccaatgt ggattgctga tatggatttt aaaataccaa cagaaataga
    21001 aaacaaattt attgaagctg taagaagagg tgtatttgga tatacatact gttatgatga
    21061 attttatgat tcagttattg gttggcaaaa aaatatgcat gaggtaaatg tagaaaaaga
    21121 atggattaca ttaacttatg gaactgtatc aacacttcat tatgtagtac aagctttttg
    21181 taagaaaggt gatagtataa tattaaatac accagtttat gacccctttg aatcatcagc
    21241 aaaaaaacaa ggtgtaaatg taatttgtaa tacattagat gttgtaaatg atagatatta
    21301 tataaatttt gataaattag aagttcaaat taaagaaaat aagcctaaat taatgatgtt
    21361 ttgtacacca cataatccat ctggaaggat atggacaatt gaagaaatga caagggtagc
    21421 aactatatgt aaagaaaata atgttatttt ggttgcagat gaagtacatg cagagcatat
    21481 tcattatggt acatttaatt caatacttaa gattggaaaa gagcttttag aaaatgttat
    21541 tctattgaca tcaccaaata aaggatttaa tcttggtgga ttaaagactt cttattcaat
    21601 agttataaat aaggatataa gggacaaatt tagaaataaa ttaaagcaaa attctataac
    21661 ttctccaaat gtgtttggaa taataggatt gataaccgct tataatgaat gtcatgagtg
    21721 gttaagtggt gtaaatgaat atataaaatc aaattatgaa cttttagaaa cttgggtaaa
    21781 taaatataat aagataaaat tgatgaaaat ggaatcatct tacttagctt ggatggatat
    21841 aagtggatta ggtattagtg caagtgagtt tacagataaa ttggctatag atacaggagt
    21901 attattagaa gatggaagtc attttgtaaa agatggtgag aagtatgtta gaataaattt
    21961 aggaactcaa aaggaaaatg taattgaagc cttaaataga atggatttat ttttaaagtc
    22021 tttataaaaa tttggttgaa ttagtatttt atataaattt aaactattaa tatggtatat
    22081 acataagtag aatttgtttt agattactta agtatatacc atattttata taaaaattaa
    22141 atttgcatta gtcatgtgat aactatttaa attcatatgt attttgtatg tataatagat
    22201 ataattatta tttaaactta ttgtttattt aatttttcaa tagaaaaaga tttatctgta
    22261 agtttaaaat tatcttttat acccttagtt aagtatactt tcttatcctt agttatgaat
    22321 atagcatcta cattatcaat tttattaatt aaattcatac ctttttcaag accaagacca
    22381 aatgtagaag tggataaggc atcacaatta atagatttat cagagattat tgtaacacta
    22441 cttaaattgt tttcaaaagg ataccctgta aatggattta acatatgatg atatattttt
    22501 ccgtcttttt cgataaatct ttcataaatt ccagaagtaa caacagactt atttgtagtt
    22561 tctatgtttc ctatggattc accattttta ctagttgggt cttgaatacc tattttaaaa
    22621 ggtttatcat ttttaccatt ttctaaagta aatatatttc ctcctaagtt tactaaacct
    22681 ttttttacat cctctgattt taaataggct acaattttat cagcagcata tcctttagct
    22741 atggcaccta aatcaatttt catattttct ttggttaatt ttatagattt atttttttca
    22801 tccaatatga tgttcttata atcaataaga ggcagaagtt tttgtatctt agaatcactt
    22861 ggaactttag ctttatctgt tccaatagcc cataaatttg ataatggacc aattgttatg
    22921 tcaaaatatc catctgataa tttggaatat tgtatagctt cttttacgac gaaaaatgta
    22981 tcatcagaaa ctctgacaaa ttttttacca gcattatcat ttattttaga aacatcactt
    23041 cctggtatat gagtgctcat tttgttgtca atatatctta aaattgaatc acattcattt
    23101 aagattttat cacttttgga ttcttttaca ttaaatacag taacttcgtt tactgtacca
    23161 aggtagtagc tagttttact atatttagta ttctggcttg aactcctaaa aaatgaaaat
    23221 aaaattaatg ctaaaatcaa tatcacaaaa ataaatgtga tttttttctt attcatggta
    23281 tattcctcct atgaaattgt gttattattt tattataaca taatttcata ggaggacaaa
    23341 aaatgaagaa aaaagacatt cttcttattt taggcatttt ggttgttatt acagcatgtt
    23401 atgggataat aaatgttata aattctaaaa atgctggaaa tattgagatt tatgtagata
    23461 ataaattgta taaaactgtt tcaataaatg ccaaagaaga atttaaaata gagagtagag
    23521 gggggtataa catagtaaag attcatgata aaggggttga gatagtagat gcttcatgcc
    23581 ctgataaggt ttgcgtacat actggattta taaacaagcc aagtcaaagc atagtttgta
    23641 tacctaatag agtgagcata aaaataaata caaatgaaaa gaatgataat caagaagata
    23701 taatttctaa ataaaataat aaaaataatt gaaaggaatt ggtgataatt atggttaact
    23761 taggaaacga ttgggatgaa ttattgaaag aagaatttga aaaagattac tacttaaact
    23821 taagaaaatt tcttatagaa gaatataaaa cacgccaaat tttcccaaat atgcacaata
    23881 tatatgaagc tttaaaacac acttcataca aagacacaaa agtcttaata ttaggacaag
    23941 acccttatca tggagataat caagctcatg gtttagcttt ttcagttcaa ccacaagtga
    24001 aaactccacc atctttatta aatatgtata aagaattaaa agatgattta ggttgtttta
    24061 tacctaataa tggatattta atgccttggg cagaccaagg agtgttactt ttaaatactg
    24121 ctcttactgt tagagcgcat gaagctaatt ctcataagaa caaaggatgg gaaattttca
    24181 ctgatagagt aatatctatt ttaagtgagc gtgaagaccc agttattttt gtactatggg
    24241 gaagtaatgc acgtaaaaaa gtagagttga ttgatacaag taaacattat attttggaag
    24301 cacctcatcc aagcccattg tcagcaagta aaggcttttt tggatgtaaa cacttctcta
    24361 agataaatga aattttgaaa aagctaggaa aagaacctat taattggcag atagaaaata
    24421 tataaaagta aaaggtaaca aaatgataac aaaacaacaa taaacaatga cattgttgta
    24481 actaatagaa atatgcttaa atagttgaaa atactatgta tgcatatttc tatttttttg
    24541 tcaagttgac aactcttgaa aaaatagtta caatttagtt acacaaaaaa cacaaataaa
    24601 aaaagaaact tacaaagcag aattttatga agcaaaatat atagtgtaaa aaatcttagg
    24661 gaggaaattt tatatgaatt ttaaaaaatt gagtaatgct aaagtctcgg taatggcagt
    24721 tgttttatca gttggaatat tatcgggata ctctgcgctt aataaacaag taacattagt
    24781 agtaagggga gaagaaagaa ctatatcaac atttagttct aatgtaggag accttttaga
    24841 atctcaaaac attagctatg attcaaatga tatagtaact ttagatgaaa atacaaagtt
    24901 atctaatgga gataaaatag aagtaattga tgtaaaggaa aaaacagttg tagaaactaa
    24961 agacattcca tttgaagtta cagttgttga agatggctct ttattaaagg gtgattctaa
    25021 ggttaaagaa gaaggaaagt ctggtaaaag tgaattaata tataaagaaa cttatcacaa
    25081 tggaaagaaa gtagaaaagg aatttgtgaa aaaggttgtt aaagctgagc cagtaaataa
    25141 ggttgtaagc aaagggacaa aggtagaaat gcaagtagcc tcatcaaggg gagaaagttc
    25201 aagaagaatg gcttcatcat catctagtag cagtagtagt aacaatggta aaaatatgag
    25261 agtggtagca actgcatata ctggtcacag tataactgca acaggaacaa aacctaagtg
    25321 gggaacaata gctgtagacc ctaaggttat accatatgga actaaagttt atatacctca
    25381 atttgacatg gtgtttactg cagaagactg tggtggagca ataaaaggaa ataaaattga
    25441 tatctacatg aatgattcaa aaacagttta taactgggga agaaaaacta tagatatacg
    25501 tatattaaaa tagttaaata atttatattt ttactggaaa ttatattttg attatataga
    25561 gaagaaactc tttatagatt ctaaaaatat aatttccagt tttttatttt ggatatgtaa
    25621 taaaacaggt aaattttaac catgtataga taaaagctat ttaaattata atttactatc
    25681 atataaatct ataaaaattg ttgcaaagag tcaaaatata tgatattata gatttcgttg
    25741 agaaggattt cattatggga gtggatgggt gccggtgtgc cctctagtct tcaaaactag
    25801 tatgaggggt taagagcctc ttaggtgggt tcgattccca cgcattcccg ccaatatgta
    25861 aaaggtatct tttaattaaa agataccttt ttaaatttat tttaagataa tttattttta
    25921 ataatatata atgttttgta ttatataatg taaattttct aatactatta tatatttaga
    25981 taaaaatcta ggagtgtgga aagatggaaa ataattttac aacgagaact agttttctag
    26041 ttggagatga tgggataaaa aaacttaata attcaaatat aatagtattt ggagttggag
    26101 gagttggtag ttttactgtt gaagctttag caagagctgg agtaggcaat attactattg
    26161 tagattttga tgatgtagat ataaccaata taaatagaca aataccagcc ctacattcaa
    26221 ctgtaggaag atacaaagtt gatgtcatgg aagaaagaat attagatata aatcctaata
    26281 tcaatataaa aaaaataaga agtctttata ataaagatac tagtgacgaa atactaactg
    26341 aaagatatga ttatgttgtg gatgcgatag acatggtaag ttccaaaata catctaattg
    26401 aaacttgtga aaaaaaagga ttgaaaataa taagttctat gggtatggga aataaattag
    26461 acccaactaa aatagtcgtt acagatatac acaaaacaag tacttgtcct ctagctaaag
    26521 ttatgaggaa agaacttagg gatagaggta tcaaaaagtt aaaagtagta tattctactg
    26581 aacaaccaat agaacttaag aagaaagtaa tgaatggtag aaaagtaaca cctggtagtg
    26641 tatcatttgt cccatctgta ggaggtttaa taatcgcatc tgtaatagta aatgaactat
    26701 taggacaata agttttaaat attttaattt ataaatttta tataaaaatt tgaaggctag
    26761 aagcatgaat acaaagcaat tttatattca tacttttagc ctaattattt tatattacct
    26821 tattttatgt agttgtagtt ttatttttta gattatgtat ctatttcata attatatttt
    26881 gtaaatataa tttctccatc actataaaaa acaatatctc ctattctatc tgttctataa
    26941 attgatacat ggttttgttt tagattatta ataacctccc tatgtggatg accatattga
    27001 tttttatatc cacatgatat tgcagctata tctggactaa ttttttttat aaattctaaa
    27061 gatgaagaag aattacttcc atgatgacct atttttataa aattaatatt atttaattta
    27121 aaagaatgta aaatttcttt ttcattttct tcttcagcat cacccataaa taaaaaagaa
    27181 ttatcattaa aagttaattt gaaaactata gaatttaaat tagattcttc ttgtatatat
    27241 gatggactta atacatatat atttatattg ttatctatgt ttaaaacatc atttttatag
    27301 agatgctgaa tagataagtt tttatccgta caagaattta ttagattttg ataagcctta
    27361 ctatcagttg attgttcagg catatatatg gagtttacat taaatttttt tataatatta
    27421 tcaagacttc ctatgtggtc tgaatctgga tgagttgcta ttataatatc aatagttttt
    27481 attctttttt gtctaagata actaataatt atattttcgc tatcttcatc acctccatca
    27541 attaatatat tcttatttgt gggtgtttga actaaaatac tatcaccttg tccaacatca
    27601 atcatatgta tagatagtag agattttttg tcacagccga ttaaaagtga tattataata
    27661 agtattgata aaaaaatttt atttctcaat aaaaaatcac tccattcatt acatgtttat
    27721 ataaatttat gatgggtaat ataagatata tatgacttat tatattttat attttaaaca
    27781 atataaatga aattaatacc ataataaaat tggagttttt tatatataca aaataaaatt
    27841 tttaaaatta agcaataaaa aaggtaggag gattttatgt ttttcaaaga tattgaacta
    27901 aattcaaaaa aagagttaga cccatatttt gatttagtag attatgaagc ttgtgagtac
    27961 tgttttagta ctttatatat gtggcaacat gtttataaga caggatatta tataggtgaa
    28021 gattttgccg ttttagttgg ggaatacgaa ggagatagct tctcaatatt accacttgct
    28081 aaaaaagata aacttccaga agttgtagat tttgtccttg aatatttttc taaaaataat
    28141 aaaaaaatat acttaagagg tattactact gaagtagtag agtttttaaa agaaaaatat
    28201 ccaggtagat ttgagtatat agaagaaaga gatttatttg actatattta tgatgcagaa
    28261 agtttaagaa ctctagctgg taaaaagaat caaaagaaga gaaaccatat aaactatttc
    28321 ttaaaagagt atgcaggtag atatgaagct aaattattag ataaagaaaa ctttgatgag
    28381 tgtttagtac taatgaagga atgggaaagt aataaggaag aaaataatga atttgatgaa
    28441 agtatggatg atgaattaat aggtatcaaa aagatattta accattatga catattaaaa
    28501 gataaggtaa aagtgtttgg tgtttatgta gatggaaaat tagaagcttt tagtatagga
    28561 gagcttttaa atccaaatat ggcattgatt catatagaaa aagctaatcc cgatataaga
    28621 ggtctgtatc catttataaa tcaacaattt ttggtaagtg aatttaagga cgttgagttt
    28681 gtaaatagag aagaagattt aggtattgaa ggattaagaa aagctaaact ttcttatcat
    28741 ccttgcagat ttgttgaaaa gtacagtgtt agggaggctt aatagactat atggagatta
    28801 ggtatgctaa agaagaagag atagaaagta taaaagatat ttggagttat tgttttaacg
    28861 atacggagag ttttatgaag tactatttta atgataaata taaatctgaa aatactgtag
    28921 tagctttaga tgaaggaaaa attatttctt ctcttcagct aaatcagtat aagttattac
    28981 taaatagcaa ggtatataat acatcatatg tggtaggagt ttctacactt ccagagggaa
    29041 gaggagctgg atatatgaac aaagtaatga aatttacttt aaacgaattg tataaaaaag
    29101 ggcaattagt ttctatattg atgcctattg actatagact ttatagaaga tttggatatg
    29161 agcattgtta cgaccagatt gaatatacta ttaacacaga tgatttaaaa aattttaagt
    29221 caagtggaaa aatgataaag tctaatttat cacaaattga tgatttgata caaatagata
    29281 gaactttttt aaatgaggtt aatggtaatg tgttaaaaga tgaacattat tatgaaaact
    29341 tatttaaaga gattcaaagt gaagatggat ttttatacat tcatgaagga aatgaaaaag
    29401 atggatatat agtttatttt cttcaggaag ataaaatgtt tgtcagagag ttattttata
    29461 aaaatataga tgcccttaaa tcaatgctta aatttatata taatcacaat actcaatgta
    29521 agatagttac tatatctact cctacaatag ataagataag gtttatatta gacaacccta
    29581 aagatagtga tataaaaata aaacctttta tgatgggaag agttataaat gtaaagaagt
    29641 ttattgaaga tatagatatt gagaaggata ttaatagctc atttaattta ttaatagaag
    29701 acaagtttat agatgaaaat aatggtctat ttaaaatttc tatacagaat aagaaggtat
    29761 ctgtagagca gttagataaa aaaggtgcag aaaagcctca agaagatttt gatattaaat
    29821 tagatataaa taccttaaca cagttatcat tttcttatat agatgtaaat gaagctattt
    29881 tcttaaatga tataaaagat gtttcagaag aaacactaga aacacttaat tgtatttttt
    29941 ctaaaaaaaa taactatata aatgaatata tataggtaga gtacgttaaa agattttaaa
    30001 aatcttttga cgtatttttt tgtttagata acaatttatc ttgtttaaaa attttctatt
    30061 tgaaaataat ctaaataata tacttttata tgggagtgat tataattcaa ataagaagac
    30121 cattattaat tatattaatg tttgtggtag ctatatcatt tatcattaca aataacacaa
    30181 aaaacgacga agaacttaat gataagataa taactataca aggagttgtc aaaggaaaaa
    30241 ttgaaaagaa aagatacaat cagtacaagg taggggtttt tctaataaat gattatacaa
    30301 aaaataaaaa tttgaagatt ggtcagaaag ttaatattac aggtaaattc aaaagtttag
    30361 ataaaatgaa gtatgatgat tttgattatg gaaggtatat aaaaagtact ggatataaag
    30421 gtatagtgta tataaataac tataaaatta ttgataaaaa taaactttac tctttaatag
    30481 gggaaataaa gttttatatt agtaaaactt ataggtactt atataagaaa aactcagatt
    30541 ttataaattc tatactatta gcagaagttg aaaatttgac tgaggaacaa aaagaaattt
    30601 ttaccagaac tggaactagt catgtaatat ctatatcagg tcttcataca ggaatattat
    30661 gtgtaattat atcctttcta ttaagaggta taaataaatt gtataaatta ttaatactgt
    30721 cgatttttat aactttatat tgtataatgg taggtgcgtc tccatccata attaggtcta
    30781 tagcatttgt tatgattttt tatttatcaa tatttattga tagaaagaaa gatggaatat
    30841 cggcattgtc tctaattggg ataattttaa ttatgaataa cccctatgtt atatataatg
    30901 taagttttca attgtctttt ttagctacac tttctatatt aatattctat aataaaataa
    30961 atagtattat aaaattaagt atggtatcat tgacaatatc atcaaatata ttaactttac
    31021 ctataattta ttatacattt aaaggtatac cattgctttc aattatagga aatttaatta
    31081 tagtgccatt tgtgggagta ataatgtatt taagtattgc aagtttaatc gtatttaaag
    31141 taagtgtagt aatagctaaa attatatctt tttttaatag tacatttata gaaagcatat
    31201 tttttttact agaaaaaatc agcaatttaa gttttgcata cattaatata gaaaatccta
    31261 aattttatat tgttgttatt tattacatag gagtgttttt ttacatattt tacatagaag
    31321 gaaaagagat aaaggagcaa gagaatgaat tacaaggata ttataaggaa tgtaaaagag
    31381 aaaaactttg aaaaaatgta tcttttttat ggaagagagt attatttaat tgagaatgca
    31441 ataaaagcat ttaaagatag tctaaacgag ggaatgcttg attttaattt agatataata
    31501 gatgggaagg aaatagtctt aaatcagctt ataagctcta tagaaacact tccatttatg
    31561 gatgatagga agatagtaat aataaaagac tttgaactat taaaaggaaa gaaaaagaat
    31621 tttacagata gtgatgagaa atacttaata gagcatttag acaatattcc agacaccaca
    31681 actatagttt ttgttgtata tggagatgta gacaaaagaa aatcattagt taagaaaata
    31741 ggaaacaatg gaattgtttt tgattgtgat aagctttctg atatggattt gtttaaatgg
    31801 ataaaaaaat cttttgcttt aaatgatgtt ataatagata attctcaaat catgtatttt
    31861 attgaacaag aaggatacag agataagagt agtgaaaaga cattatctga tttagaaaat
    31921 gaaataaata aaataagttc atttgttggt aaagggaata atgtaaccaa tgatgtaatt
    31981 gataaattat ctcaaaaaaa agttgagaat gatatattca aattaatcga ttatattgga
    32041 gaacaaaatg cttctaatgc aatgaaaata ttaaatgata tgatacaaga aggcgaatct
    32101 gtattaggta tattttctat gatagcaaga caatttaaaa taattatgca agtaagacag
    32161 ttacaacttg atggatattc aacaaaactt atagctgata aattaaaaat gcatcaattt
    32221 gttgtaggaa aagcattaaa gcaaactaaa aatttttctg atgatataat tgtggaaata
    32281 ttaaactata tattagaaag tgattacaaa ataaagacag gtcttataag agatacttta
    32341 gcagttgaaa tgttggttag tagatactgt aaaagagaag caatttaaaa aatctatata
    32401 ttaataaaaa ataaatagca agatatgtta tagttcagag tagatgtaag ctaaattaag
    32461 tttgatatac aatcaactat aatatgtcta actatttatt ttttattgta taaatttaca
    32521 aaataaaaaa cccctacata ggggttatta tatataagaa atataaactg gtaattaagc
    32581 gttcataccg tttaattttt gagctaattt agctactttt ctagctgcag cattcttatg
    32641 tatagttcct ttagaagcta cttggtatat tcttttttga gcgtattgga acttagcaac
    32701 agcatcctct ctgtttccag ctgcaacagc atcttcgaat cttcttattg cagtttttat
    32761 ttgagatttt ctaactctat ttaaagcagt tttcttttcg ataacactta ttcttttctt
    32821 agctgatttt atatttgcca ccgtgttcac ctccctgtat ttttttatca tattcatcgt
    32881 caacatatta gattttaaca gaaataaatc taaaaatcaa ggattattat ttatatattt
    32941 taataatgtt ttttattttg attttttaga ctgtaaattg tgtataaata atttgcaata
    33001 tcttgttttt aaattggtat attttgtgtt ttaaatattt tgacatatat aattaatatt
    33061 tcattttgta acaaatattt gagataatac aaactattaa catacatttt gatagtattt
    33121 ccaataatta taagataata caagaaatta ctcatttttg taaatttaat gaaaaatata
    33181 atataaaaga caggaagaaa atcttcctgt ttttttatac tattttcttt aatgttcaat
    33241 tatgaatgat gatataattg agatagtaaa ggagtgaaac ctgtggctaa aaaagttaga
    33301 ataggagaca aactggtcga aaaaggatat ataacagaag aacagcttaa atgggcacta
    33361 tcagaacaaa aaaacagtgg aaaaagacta ggagaatttc tagtacaaga agggcttata
    33421 gatagtaacc tactaataag tgtattaaaa gaactcttgg atatagaaag tatattttta
    33481 gaagggacag aaatagacac tttagctaca aagatggttc cagaaaatat atgcaaaaga
    33541 tatactgtat ttccattcaa aatagatgga aataaaatat gtctagccat gtcagaccca
    33601 caagacagag aagcagttca agatgtaagg cgtatgtcag gtaaagacgt agagatattt
    33661 atatcaagta cagaagatat aaacaaagca ataggtcatg cttatgcaca ttcagaaata
    33721 aataaggcaa tgactgagta caacaaaaat agaactggtg gagtaagaga aacagtaata
    33781 cttgaagaag atgtaaatgc tgctccaata gtacgattag taaataacat actagaaaat
    33841 gctgttagaa tggaagcaag tgatatacat atagaacaaa gtgaaaatta catgcgtgtt
    33901 aggtttagga tagatggaat gttaagagaa tatatgagga tgaactcagc accatataag
    33961 gcagtaatca gccgtatcaa gataatgtca gatataaata tatctgaaaa gagaatacca
    34021 caggatggta gaatctattt aaaagtggat aataaaccca tagattttag ggtttctaca
    34081 atgccaacta acagggatga aaagatagct atgagggttc ttgataagag taattttatg
    34141 gttagtaaag aagtactagg aatagacgaa catggctcta agatatatga tgaattgata
    34201 aacactcctt atggtcttat attggttgtt ggccctactg gaagtgggaa aaccactaca
    34261 ttgtattcaa tgttaaatca actaaataca gaaaatagaa atctattaac aatagaagac
    34321 cctatagagt atgaattacc tggtgtaaat caatctcaaa taaatgaaaa ggcagggctt
    34381 actttcgcca gcggacttag agcttttatg cgtcaagacc cagatataat aatggttgga
    34441 gagataagag atactgagac agcagaaata gcaattagag cttctcttac aggacattta
    34501 gttttaagta cattacatgc aaatacagca gttggagcaa tttcacgtct tttagatatg
    34561 gatgtggaaa gttttttaat aacttcatct gttttaggtg taatatctca aagacttaca
    34621 cgaaaaatat gtgagcattg taaggtttca tatgaagcag atattggaga aaaaaaggct
    34681 cttggtattg atgtaaatga atcagtaact atttatagag gaaaaggttg tgaaaggtgt
    34741 aataatactg gatataaagg acgtctaggt atatttgaaa tgcttgaaat tactccagaa
    34801 ataaaagagt taatagattc atctgcaaat caaagagaaa ttttaaagat ggctagaaaa
    34861 caaggtatgg ttagcttaaa agaggatata gttaaaaagg ttttaaatgg aaagacaaca
    34921 gtagaagaaa tgattagaat aattttgatg actgattaaa ggatgatatt atgaaaagtt
    34981 ttaaatacac agtaataaaa gaggacggaa aaaagcaaac tgatgttatt gaagccaacg
    35041 attttaatga agctagaaat cttcttagaa agagaaatct tagagttatt gaaatcaaag
    35101 aaagcaaaaa taaaaatata agattatcta gtataaagag aaaaaaagac ttaggagctg
    35161 accagataag ccacttttgt agacaatttg ctattatagt atcttctggt ataaatagta
    35221 tttctggatt agaaacatta gctagaaggt caactaacat tacattaaga gaagaaatta
    35281 atcgtatagt agcagaaata aaagtaggtt ctactattgc agattcaatg ctttcatcaa
    35341 aatcaaagtt tccaaagtta cttggtgcta tggtagctac aggtgaagct acaggtaaat
    35401 tagatgaagt attaaaaagt atggcttcat tttatgcaag tgaacacagg gttaaacaaa
    35461 agcttagaaa tgctgcaaca tatccattaa tagttttgat ttcttcattt ataatgattt
    35521 ttatatttac aacatttatg gtgcctaaga tgattaattc aattacaaca gtaggagcaa
    35581 ctcttccact tataacaaga attgttatgg ggtttggtat gtttatgaag aagttttgga
    35641 taatagtact tttagttatt atattattta tctatcagtt taaaaaatat ctaaaaacgt
    35701 cagttggaag ggctcataaa gatagagtta taaataagat acctgtttta ggaaaaggaa
    35761 taaattgtat ggtagctaca cgattttcaa gagcattgta tctatttgta tcaacaggat
    35821 acccattagt tcaagggctt gattatatta tagatagtgt aaataacact atggcagaga
    35881 agattttagc atcagctaaa gatggaataa caagaggaga aggcttagca gaaaatttag
    35941 agagatatac gtattttgac tctgtgttgg tacagatgat agctataggg gagcagacag
    36001 gggaattaga gaatataagt agacagatgg cagaatttta tgagtatgaa tccgagattt
    36061 atttaaatag gatggcctca atgatagagc ctgttttaat aattgcagtt ggtattatag
    36121 ttgcgatact ggttgtatca atattcatgc caatgcttag tatatatgat gccatgtagg
    36181 agggaaagga caaatgaaca aggtttatgt atcatattat ggcgattcta tttccatagt
    36241 tgagggcaga tataaacacg ataaggataa gttttatgta aaaaatttta atgtgttttc
    36301 aatagaggat attgcacaag atttttctaa ggaaaagtat gctctattga gatacgcatt
    36361 agaaaatgtt aagttaaaat caagacatgt agttttttgt ttaaatacaa gagatgtaat
    36421 tttaaaaccc caaaaacttc ctaatatgga caaaaaggat ttagacggat ttatgaagct
    36481 agagatggac gaaatgatgg ctttggagtc agatgaatat gtattttcgt atgaagtatc
    36541 tagtgaaaca cctgataatt cagatggcga tgaatcaagc ttaaatctta ttattggagc
    36601 tatacaaaag gaagaggtaa atgcaattgt agagataatg catgaatttg atttagtatt
    36661 agatagaata gatacattat caacagctta cttaagaatg cttaaaaatt tagactacaa
    36721 tgatataatg gtaaccaata taagtgacaa tagcacaatt ataaatatat ataagaaaga
    36781 tactttattt attagtgata atatacctat aaagataact gctaaagata tggacatgca
    36841 attattaaat gtagtagaag aatcaaaagg tcttatgaat tactattcgt caagaaactt
    36901 tggtaaggtt acggatacta tattaatatt aggaaaaaga tattccaata aattaattta
    36961 tgaaactttt agctctgcat tttcaagcta tgtttctcaa ggccttactg agataatgga
    37021 tatatctgat atgataactg gagatataga tgaagatgat ataaattcaa ttgtagagct
    37081 tttaggaagt atgatagaac ctaaagggaa aagagatttt gaaaatataa actttttacc
    37141 aatggatata cttagaaaac agataaaagc taaacaaatg aaaaacatac tgaaaattgc
    37201 tccaatagtt attttgattc ttgctatacc ttatttatgt ttaatttttt caaataattt
    37261 agcaaataag gaacttgaaa atgttaatgg tgaaataaga aatattgaat ctgcatatta
    37321 tcagattgga aatatagaaa aaatgataca gagtaaaagc gaagaaataa aggtatatga
    37381 tatgttaatt gggaaaaagg taaagtggga aaatttattg gatgatatag ataaaaatac
    37441 tccaagtaaa gttgaactaa caagtttatc aacaacttat caaaatcttg gaactaataa
    37501 taaagctgat aattcaaaaa gtaataagac tacaacagat aaatcaagta acaatgaaac
    37561 aaaatcaagt acgaaaagtg atagtaatgg agataaaaca gataatgatt taaatgaaga
    37621 taagactaca aatgtgtcag aagcattaac tggaaatagt gagactaata gtaataacac
    37681 ggataaagat gataaaactc cattgtatga taagatacca aatgttataa atatagaagg
    37741 aaatgctaaa gattcctctt atgtaggtca atttttatat aaattaaagg gattatacta
    37801 tttcaaggat gttaaattac atagcataaa aagtaatgca gaagattcta actatacatt
    37861 tagtatgaca ttatacctga aagaaggtgt attaactaat gaataaagat atatttaaaa
    37921 aagatataaa agatatattt aaaatggaag ttagtctaaa agggattctt ataaaggtta
    37981 taattttatt agctatttta tcatatggtt attttggact ttaccctcaa tatcagaaat
    38041 atattgctac aaaaaattct gtaaaacagg ctactgaaaa attaaatata tataaagaga
    38101 aaactgcact tatgccaaaa tatgaaaaac aacttgaaga agttgaaagt gaattaaaag
    38161 aaaaaagcaa aaatctttta tatgatatgc aagatggtct ttttttaata ggtttagata
    38221 aaaaaatgaa ggcttataat attgacttaa ccagttatga cgttggaaat gttaaagaat
    38281 acgaacattt ttatggtata tcaacaacaa taagtgttag aggtgattat agaaatgtca
    38341 aaaaattaat ggcttattta gaagaacaaa aaaatgttac tcaaatacta gattatacaa
    38401 tgacttcata tatagaacca gaaaaagaag aggaagaaac aacaaacaat aaggatttaa
    38461 ttaaaaatgt gaacataaat aaagatacaa aaatatattg ggtggaaggc gaaaataagt
    38521 ggcatttata taaggattgt ccattgataa aagagggaga gattataaaa aatgacaaac
    38581 ttttagatag gtctactaat tatctatgta atacttgtgt acttagagct gcaacagaaa
    38641 aagaagcaaa aaaagaagtc gtagctccaa aggcagaagg tgtagtagat gctacattta
    38701 aatttataat gtacactaaa gagaatacta caatgatact tgatacagat aatccatctt
    38761 catggagacc aggaaaatat aatccattta agtctagtgc gaaataaagc taagtaagct
    38821 ttaaagatag gtgatgagtt tgtacaaaaa taatgaaaaa ggtcttactt tattagaagt
    38881 aataatagct gtttttatac tgacaatagt tttaagtatt tcttataaag tgttcaatgg
    38941 tataacatca gcagtaaaaa agcaacagat tattacagat gctcaagtaa atattaatct
    39001 aattaataag tatctaaata gagatttgga aaactgtaaa gagctaacta aaactggttc
    39061 aggtaataat tatgaataca atatagagat gccagataat gttgtaaaat atgaagtttc
    39121 tatagaaact aaaaaaaata cagaggtata ttctgtaacg agaatccaaa acaatacaat
    39181 tgatacagaa aatgaagtta gagaagagat aatctataat caaccactag ttcaaaacaa
    39241 taaagaaatg aaggaaacac catttaaaat agaaaagcaa actggtaaat ctatttatac
    39301 tgtaagtata tactataatg aatcagtgca agaaagtcat aaaaatagca atttaaataa
    39361 caaaacttat acatttgatg ttatgtcaag aataggataa taagaattta ttaaaaaata
    39421 agtaggttga taaaatatga gtaaaaagaa tagtgaaaga ggattttcct taattgaagt
    39481 gttagtagct atggctatta tgggaattgt actatttgca ttttttaata ttatcaatac
    39541 taataacaaa gcaaacacta aaaatgacac agatataact tccttaaact atgtccaaag
    39601 tgaaatagaa aatctaagag aaaagataaa aagtggagaa tttgattttg atagtttaga
    39661 taaactagaa gatggaactg tcgtatatga aaaattaata gataaatcaa aaaaagttgt
    39721 atatgataaa gttcttagtg aaggtgacgt gagcttatat gatactccat atgaaaagat
    39781 tacaacaata aaagatgaag atggtaattt aatcgacaaa ggaaatatta caaataagat
    39841 aaagactatt gtagaagata aaagtggtca gatatataaa atagctgtaa ctgggaaaag
    39901 catgaatgac tattcaagta aaaaagaggt taaaattgta actgaaatat ttaaagataa
    39961 ataattttac ttgggggtga gattttgagg aagtggaata aatttaaaag tgaaagaggg
    40021 gcagctttag ttttagtttt ggttgtagta gcattgcttt ctattgttgg attgatattt
    40081 tcaaatcaga tagctaatag aataaaatct acaaagacta ctaatgaagg tatacaagca
    40141 aagtatttag cagagacatg tgtggaaaat agtattgata aagcatatga aaaattgtat
    40201 gatgagcttg agaaaatgga taatgagttt aaaagtgaaa atcaagaaaa atccatatct
    40261 aggtcaaaat taagaaatat atcagatgaa gattttaata atcaagatga ggaaaatatt
    40321 gaagcagaaa gacttggata tatgaataat ataaatttct atttaaataa agcttcttca
    40381 gacttggaaa aagctagtat ggaattgaaa aagctatatg atttagatat gttggactat
    40441 agagacattg aatatgtaga tgcaaatatt atttcacata gagattctat cttagaaatt
    40501 tgcaagaatt atacttctgg agatattagt aaaataaatg aatatattct gaaagaagat
    40561 atagactcaa ctacattgat tgaggcaaag ttagtgaata atgatattct tttaaaaaag
    40621 tttttagaag aaaataaaat tgaaaatgaa catttaaatt cagccttttc acatacttat
    40681 aaggcattag ataacatttc tttggcgatg caaaatatga ttgagtatag acatacgttt
    40741 catatagatg agccaaaagt agaagtatct aatgggattc cagactctca acaatattat
    40801 gaactaatac aaaatcctat aataaatagt atggagtata gctggaatag taaatgggat
    40861 acattagaaa acctattgga aattttacca aatcaaactc aaggatttaa ttctttaaga
    40921 gttcatttga gaaataatgt aagaaaattt gagaagttaa gcgataatat atctagtggt
    40981 aaaaaaaata cagcaaaaaa tttcttaaag tataaagagt tattgtatga aatatcagac
    41041 caatgtaatc aactaaaaag tatgtcttat gagaaaatac ctgttaaata tgataacatg
    41101 gctttgataa caacttttga ctatatacaa aatgagcttt tagcagagat aaaatgcaga
    41161 ttaaaagaat taaaaccaca agaaattgat aaaacagaag gtattactat aaaaatacct
    41221 ttttataagg ctgactacga catgacaaaa gaaggatggc ctaaattaaa agaaaatggt
    41281 tcaggggcgg agttaagctt aatggtaact ggtgataaaa atggaataaa agaagtggaa
    41341 gttacagatg gtaaaaaaaa tattattggt ttaggtgttg aagaaaattc aaattcaaag
    41401 tataaggttg acgccattgt aaactttaat ctaaatatag atacaaatgt agttggaaat
    41461 tatgatataa aagataaaat tttgattaat catgatataa gttcatacaa aaaagtaaac
    41521 taaatataag aagcaactta gtataaataa caaaataatt ttattattta ctactaaaaa
    41581 aataagtaaa ctaatagaag atatggagag taaatattat gtatatttat gatttattag
    41641 agcaaggtat aagactaaac gcatcagata tacacataac agttggaaca aatcctgtag
    41701 ctagagtaaa aggtggattt gtaaaactaa gtgaacaaat attgacatca gaagtaacaa
    41761 tgcaaatggc aaaagacata gcaggggaat ctatgtttaa agtaatagaa gaacatggag
    41821 aagctgattt ttcagcttct ctaaaaacag gagaaagatt tagggtaaat gcatataggc
    41881 aaaaaggaaa ttacgcaata gcaataagga ctataacagc agaaattcca acatttgaaa
    41941 aattaggcct tccagagagt ataaaatctt ttactgaaaa gcataaagga ttagttttag
    42001 ttacaggtcc aacaggaagt ggtaaaagta caacacttgc aagtatgata aatataataa
    42061 atgaaaaaca acaaaaacat ataattacac ttgaagaccc gatagaatat gtacatcatc
    42121 ataaacaaag tttagtaaat caaagagaag taggaactga tacagaaagt tttcattcag
    42181 cccttagagc tattttgcgt caggacccag atgtaatact aataggagag atgagagacc
    42241 ctgaaactgt ttcaatagca ttaacagcag cagaaacagg tcatttagta ttttcaacac
    42301 tacatacagt aggggcagct aagacaattg atagaatagt agacatgttt caaccatccc
    42361 aacagcaaca aataaaaaca cagttatcta cagtttgtga aggtgtggta tcacagcagt
    42421 tacttcctac agcagatggg aaaggcagaa tagcagcaat tgaattgatg tttgctactc
    42481 cagcaataaa aaacctgata agagaaggca aaacatatca aattccaaac atgatacaaa
    42541 ctggagttaa agtaggtatg aaaactatgg accaagattt aatggaactt tataaaaatg
    42601 gaaagattac aaaagatatg gcacttagta ggtgtactga ccaagagttt atgacaagaa
    42661 tgataggtgg agtaaactac aatggatatt ataatcgtta atctatatgt atttatagtg
    42721 ggtatagtgt ttggaagttt ctttaacgtc tgtattttta ggattccaga aggtatatct
    42781 atttctagac caccttctca ttgtatgagt tgtaatacta gactaaagcc aatagactta
    42841 ataccagtgc taagctattt aatgagtggc agaaagtgta gatattgtta tgagaaaatt
    42901 tctagtagat atgctatagt ggaattaatt acaggacttt tatttttaac agtatttatg
    42961 ttatatggaa tatctacatc aactatttat tatttggttc ttgtgtcttt actgattata
    43021 attacattta tagatattga ccactttata ataccagata aaatattggt ttttggagct
    43081 atattttcta tgatttttaa ccttttattt aaagaaattc cagttaagga ttcaattcta
    43141 ggtgttttta tttgtggagg aagtgtctgg attatagttc ttttgattga atttgtaata
    43201 aaaaaagagt gtatgggtgg aggagatatt aaactatttg caatgctagg cctttacatg
    43261 ggtgttaaaa atggtctttt gacagcctta ctaagcgttt atgtaggagc agtctatgga
    43321 atctgtgtaa taattataag tagaataaaa ggaaaggaat ataattctgt tataccatat
    43381 ggacctttta tatctattgg agcattaata acaatcttat gtggaaagaa attacttgaa
    43441 ctttattttt ctatggttat atagatgata gtcaagttaa ataaagtttt aatttaaaaa
    43501 aatgaattaa agtatttaat aaggacaata ttattattaa ccctattact aaagtgctac
    43561 aaactatgga gtatataata ataatttcct tattttttgc acatttgata aataaatctc
    43621 tatgtgtttt ttgtgataga gaaaagaaaa atttatacaa tacgtttttt atttacataa
    43681 taactgtagt tttatctgta ttaatatatc taaaatttgg gattagtgta gaatgtgtac
    43741 aatatatggt tttaattcca tttttaataa ttatatccat tgtagattac tacacaatat
    43801 atgtatatga tataacaata gttagtggta taatagttca aggtataatt tttttggcct
    43861 ttttcaatat agctcaattt gattatataa atcatatatt tggactattg ataggcttta
    43921 ttatacctta tattattgct aaactaacaa aaggattagg ctatggagat gtaggtctct
    43981 atagcttatg ttgctttgca ttgggaaata attatgggtt ttatgtgata gttttatcat
    44041 ttattttagc gtttttgttt tttattattt tatacataac taaagtattt aaagatgtag
    44101 atataagaaa gcaaattcct tttacacctt ttatttcctt gtcgacaatt ttaataatat
    44161 ttacagagta taatatattt aatttttatt ataatttgtt atacaaattt atataacagg
    44221 aggtaagaaa tgtacgtagt agtagggtta ggtaatccag gaaagaagta tgagaagact
    44281 agacataacg ttggatttga tgttatagat attcttgcta aagaatacaa tattagtgtt
    44341 actaaaataa agcataaagc tttgattggt gaagggagag taggtactga aaaagtatta
    44401 ttagttaaac cacaaactta tatgaattta agtggagaaa cattaataga tatatataaa
    44461 tattataagg ttgatttaag taatatagta gtagtatatg atgatataga tttagaagtt
    44521 ggaaagatac gtataagaaa aaaaggaagt ggaggaactc ataatggcat gaaatctata
    44581 actaattgcc taggttcaaa tgactttcca agagtgagag taggtgtatc taaaccagaa
    44641 gctggtcaag acttagcaga ctttgtactt tctagattta gaaaagaaga atctgataac
    44701 ataaatgaag cattagaaaa agcggcagat gctattgact caataataag agaaaatata
    44761 gatatgtcta tgaacaaata taatggatag tgagagggag atttaaatga atgatgtttt
    44821 tttatatcct ttgcaaaatt caaaagagta taaagatata ataaactgta taaaaaatac
    44881 aaaaggctca ttattggtta atggactttt accagtacaa aaacctcata tatcgtattc
    44941 tatatttaat gatttatcac gacaaatgat ttttataaca agtagtgatt tagaagcaaa
    45001 gaaagtatac gaagatttaa gtttttatat ggaagataaa gttgaatatt taggttttca
    45061 agatatttat ttttatcact tggatgcaaa ggacagaaac gaagaagcga agaaattaaa
    45121 agtattgtta aaactagcaa ataaagaaaa aatcatttta gtaacttcta ttgaggcagt
    45181 tttaagaaaa tacataccaa aacaagtttt gctcgatagt gtatctcatt ataaggtggg
    45241 agatagctta gacttagaaa agttaactga gaaattagtt tcattgggat atgaaagagt
    45301 ttcaaaaata gaggggtttg gtcaatttag tataagaggt ggaattattg atgtattttc
    45361 acttgaatat acaaatccaa ttcgtatgga attatttgat gatgagatag attccatacg
    45421 aacttttgac gtatattcac aaaaatcaat tgataaattg caacaattct ctataactcc
    45481 atctagggaa tttatttatc ccgaaaaaac tacagatgca ttagttaaat taaaaaaaga
    45541 aacaactaaa aatactgatg aaggtacatt tcaaaatata gattatatat caagtaagac
    45601 ttattttgaa ggtgtagaga actatataga ttatatttat ccagaagaaa acaaaagtat
    45661 atttacttat ttagcagatg atgcaatagt atttattaat gatataacga gacttaaaga
    45721 aagatgcgaa aattatataa atgagtttag agaaaattat aaattaaatc ttgaaagagg
    45781 tctggctatt aaaaaccaag gtaaattgtt atatcactat acagatttag agtacttagt
    45841 aaaagacaag tctgtggtat taaactcgct attgccaaag tctataaata acttttctat
    45901 aaaatctata ataaattttg aaagtagaga agttcctaca tttaatggaa aggtagattt
    45961 gcttgtagaa gaattaaatc ggctgaaata taatggatac aaaataattt tagcaacaaa
    46021 taccttagaa agagcaaata aattaggaaa agatttattg gacaaaggct tagaaacgac
    46081 catttctaaa gatagagata ttgaaattaa atcttcacaa gttataattg tacctgcaca
    46141 cataaacagt ggttttcagt ataaatctat aaagtttgtt gttataacag ataacgaaat
    46201 gataggtgtt tataaaagag cgtctaagac tagcaataaa aaagttaaaa agggaaagaa
    46261 aatagaatcc tttttagatt taagtgttgg agattatgta gtccatgaaa atagtggtgt
    46321 aggtagatac acaggaattg aacaaattac agtcaatgct attaaaaaag attatatgaa
    46381 aatagtatat caaggtggag ataatctata tgtgccaata gaccagatgg acaaagtaca
    46441 aaaatatatt ggtgcagaag tagaaaaagt taagttaaat aagcttggaa caaatgagtg
    46501 gacgaaagca aaagcaaaag ttaaaaaaga aattgaagat atgacaaaag acttgattga
    46561 gctttatgca aaacgtgaaa aaatacaagg gtataagttt tcaaaagata caccttggca
    46621 ggcagagttt gaatcgttgt ttccatatca agaaacagaa gaccaattaa aggctataga
    46681 agaaactaaa aaagatatgg aatcaagtaa ggtaatggat aggctagtat gtggagatgt
    46741 tggttatgga aaaacagagg tagctattag aagtattttt aaagcttgta tggaccaaaa
    46801 acaagttgct gtattggttc caacaacaat attggcccaa caacattata atacattcaa
    46861 agagaggttt gaaaattatc ctttgagagt agaagtttta agtaggttta aaacaccaaa
    46921 acaacaaaaa cagattattg aagatgctaa aaaaggatta gtagatattt taattggaac
    46981 acatagaata atatccaaag atataaattt accaaactta ggtcttgtag tcattgatga
    47041 agaacaaaga tttggagtaa aacataaaga agctttaaag aaaattaaat ctacagtaga
    47101 tgtacttaca ctttcagcaa ctcctatacc aagaacatta catatgtctt taagtggaat
    47161 aagagacatg agtgttatag aagaacctcc acaagaaaga catcctgtaa taacatatgt
    47221 tacagagagt aaggaaagcg taattcaaga tgagatagag agagaattaa gtagaggtgg
    47281 acaggtattt tttgtataca atagagttga acacattgaa gaaatggcaa gtatgattca
    47341 aaaactcgta ccagatgcta gagtggctgt tgcacatgga agaatgactt ctaaatcatt
    47401 agaaaatata atcctaggat ttttaaataa agattatgat gtactagtct gtactacaat
    47461 aattgaaact ggtatggaca tatcaaatgc aaatacaatg attatatatg atgcagataa
    47521 aatgggattg gctcaacttt accaattgag aggtagggtt ggaagaagtt caagacaagg
    47581 atatgcatat cttttgtatg aaaaagataa aactttaagt gagatagcgg agaagagatt
    47641 aaaagctatc agagaattta cagagtttgg ttctggtttt aaaatagcaa tgagagacct
    47701 tgaaataaga ggagcaggaa atattttagg ttctcaacaa catggtcata tggcagttat
    47761 aggttatgat ttgtacgtta aaatgcttaa tgatgcaatt aaaaaagtca aaggtgagcc
    47821 tattgtggag gaaattgatg ttgaaataga tttaagtgta aatgcataca ttccagataa
    47881 ttatatcaaa gatgagttga ttaaaattga aatgtataag aaaatagctt ctattgaaaa
    47941 caaagaagac atgttggata tacaagaaga acttgaggat agattctctg atatacctaa
    48001 accagtccag acacttctta caatagctta tataaaatcg ttatgtaaga tattaaaaat
    48061 agaaaagata agacaattaa aagatgaaat attattagtt ccaataacaa agtatagaac
    48121 taaacagaaa ataggttata atatagttac agaattagaa gaattattag aaaagatgtg
    48181 caaggtaaaa taacttgtaa atttaagaag ggatgtttta aatttgaaaa aagtaataac
    48241 attggtaata gctatgattt tggtagtatc tgtgactgct tgcagttcta gtaaaggaga
    48301 aactgtggca acagttgaag gtacaaagat atcatcagat gaatttaaaa aaactatagc
    48361 tctttataaa gattctatgg aacaaactta tggaaaagat atatgggata aggaagttga
    48421 aaagggtgta aaatacaagg acaagtttaa agatttaatt cttgaccaac ttataactac
    48481 agaagtaata tattctcaag ctaaaaaaga taacttactt cctaaaaaag aggatgttga
    48541 aaaaagtttt aaagaattaa aagacgctat gggtaaagat gaaaaatata aagaacaact
    48601 taagaaatta ggtatagatg atgagttttt aagagaccaa caagagaaag atttagcaat
    48661 gcaaaactat caaagtaact ttgctaaaaa gactaaaata tcagatgaag aaatgaaaaa
    48721 atactatgat acacataaag atgaatttaa aaaagatgag gtagaagctt ctcatatttt
    48781 attgaaaaca gtagatgata ataacaagcc actttcagat aaggaaaaag ctgaagctaa
    48841 gaaaaaggct gaagaggctc ttaaagaagt taaatcaggt gaggattttg caaaagtagc
    48901 aaaaaaatat tcacaagata cttcagcaag tgatggtggt aaattaggat tcttttcaag
    48961 gggtcaaatg gttgctgaat ttgaagatgc tgctttttct atgaaaaagg gtgaagtatc
    49021 tgatttagtt gaaactcaat atggatacca cataattaaa gtgacagaca gaataaatga
    49081 gcaaacatca tttgaagatg ctaaagaaac tataaaagac caactgttga aaaataaata
    49141 tcaagaacaa atagaaaaat taactaaaga agctaaggta gaaaaagatg aaaaagtaat
    49201 aaataaaatc acaatctaag acttaaaaaa agagtaatat gcttaaaaaa gctatatctg
    49261 gataagatat agcttttttt gtatattttt cttaacaatg gtaaaaataa acttaaagta
    49321 atttatggag ggattaaaaa atatgaaagc aacaggtata gttagaagaa tagatgatct
    49381 tggaagggta gttatcccaa aagagataag aaagacatta agaattagag aaggagaccc
    49441 tttagagata ttcacagcaa aagatggaga agtcatactt aaaaaatact ctccaatagg
    49501 tgaattaaat gaattttcgc aagaatatgc tgaaacatta gctgaagtac taggatatgg
    49561 agtgttgata acagacttag attctataat agctgtgtct aagcttccta aaaaagatta
    49621 taaagaaaaa agtataagtg atgagttaga agcaataata agtgaaagaa cagtaaaata
    49681 ttcaaaagat aaaaacattt taccattatt caaggaagac caaaaagaat atactagtca
    49741 agttatcatg cctataatta gtgcatctgg tgactgtata ggttcaattg tagttgtttc
    49801 aaaggataaa gatacaattg cagaaagtga agaaaaatct ttaaaaattg ctgctaactt
    49861 tttaggaaaa caagttcaat aattttatca taaagacctt ttacatgaag gtcttttgaa
    49921 gtttttgtgt aaaatattga atatagcatt aaaaatatgg tatattaaag tttgttatat
    49981 aaacagtatg gaggttatgt tatgaacaat aacaaaaata aagactcctt tctaaaagga
    50041 gcccttatac ttgggctagc aggtgtaatc gtaaaaataa tgggtggatt ttttaggatt
    50101 ccccttggaa acatgattgg ttcagaagga atgggatact atcaggctgc ttatcctgtg
    50161 tatactctat ttttaacatt agctactgct ggatttccaa cagctgtggc aaaattggtt
    50221 tcggaaaaag ttgcaattgg aaattttaaa ggtgcaaata agatatttaa ggtatcacat
    50281 acagttttat tcattaccgg tataatatca ttttgtatat tattttttgg agccgactac
    50341 atagtaacaa acgtaatgaa aaatccaggt gcgttatact ctatgaaagc cattgctcca
    50401 gcattactat ttgttcctgc aatgtctgca tatagaggat attttcaagg gagacaagat
    50461 atgactaaga ttgctgtgtc tcaagttgca gagcaatttt ttagagttgt attaggtctt
    50521 actttggctt acttgcttat gaagagtcta ggtcagactt ttggtgcagc aggtgctata
    50581 tcaggggcta caataggttc aatagcatct atgctttatt tggtgtttgc ttatatgcta
    50641 gggagaaaag agcgtagagc agagatagat gcaagccaaa gatttaaaga tgaaagagtg
    50701 tcttatattt ttaaaaagct tttaactgtt gccattccta taacaatagg agcatcagta
    50761 atgccacttg taaatatgat agataatgtt attgtaataa gaagacttat ggaagcaggc
    50821 tttacataca aagtggcaaa ttccatgttt ggtcaattaa caggtatggc aatggccaca
    50881 ataaatttac cagcagtcat aacaactgca atgagtatga gcttagttcc agcaatttct
    50941 aaagcatatg cattaggaaa taagtcaaaa gctagaaaag atactaagag tgcagttaag
    51001 gtaactttac ttatagtatt gccttgtgcg tttggtatgg cttctttagc aataccaata
    51061 atgggtcttt tatttccaca tgaaccatct tctgtaggaa ctattttgtt tactcttact
    51121 ccatgtgtat tatttttagg attaatacag acattgactg gtataattca gggaatggga
    51181 aaaccaatag tacctgtaat tgctttatgt gttggtatgc tatgtaaaat tgtaataagt
    51241 tatactttaa caggtatacc agatattaat gtactgggtt cagcatttgg tacagttaca
    51301 gcatactttg tggcagccat gattaactta ctatatgtta aaaaacacat gaatgtaaac
    51361 ttttctaaaa aagaatttat aataaagcca tttataacag ttatgacaat gtttataatg
    51421 gttaagttga gttatggtgc tttagttgga ttcttaggaa acagcatatc tacaataatt
    51481 gcaatatgtg ttggtggaat tgtatatgta gtagtaatac ttggaatagg tggaattaaa
    51541 aaagaagaga ttctaactat gccaaaaggt gataaattat ataaattgtt aaaaaaagtt
    51601 aaacttataa gataatatag gaatatatat gcaaataaag gaaatactat acaaatagta
    51661 aatctcctta tttgtataat aatataaaaa taaagtgaaa tttgctaata ggagtgatgt
    51721 tatgggtaag ataagtattg taggtcttgg accaggagac tattctctta taagccaagg
    51781 tgtgttagaa tctttaataa atagccctaa agtttttttt agaacagaga aacatccaat
    51841 aattgataaa cttaaagaaa ctatacaata cacttcttta gactactttt atgaaaaaga
    51901 ggaaaatttt gataatgttt atttgaaaat atctgaattt atcatagaag aatcagcaaa
    51961 gggtgaccta gtgtatgctg ttcctggtca tccaagagtt gcagagaaga ctgtaagtat
    52021 aatagagaga ttagccaatg aaaagcacat agcagtagaa atattgcctt ctatgagctt
    52081 tgtagacgct atgtttaact atttggctat agacccatct gagggattta aactggtaga
    52141 tgcttttgaa atagaaaatt catatataga cttggataca agtatgataa taactcaggt
    52201 atatgataaa tttatagcat ctaatgtaaa gttaaaactt atggaacatt atgactataa
    52261 tcaagaagta tgtatagtaa atggagctgg tgtcaaagat ttagaaagta aaaagtttat
    52321 aaagctttgt gaattagaca gaaatgaaaa cttttttgac tatttaacta gcttatatat
    52381 acccaaaagt tctaaaaaga tgtataatac agtacatgac ttagaaataa tagttaatac
    52441 acttagaagt ccatctggat gtgaatggga taaaaaacaa acacatcaat cattaaaaaa
    52501 ttctgttata gaggaagcat atgaactttg taatgcaatt gataataatg atatagatga
    52561 aatggtagaa gagttaggtg atgttctttt acaggttata ttccattgtc agataggaaa
    52621 tgaggagggc tactttgatt taaaagaagt agtaaatggc atatgtaaaa aattaattca
    52681 tagacatcct catatattta gtggtgcaaa attagatatg tctaagtttg agaaaacttg
    52741 ggaagaatta aagaaagaag agaaaggcga aagtactata acagatggcc ttagaaggat
    52801 accaaaacat ttaccagctc ttatgaaggc tagtaaagtt caacataaag cagcacttgt
    52861 cggctttgat tgggacaatg tagaagatgt atttaaaaaa attgaagaag aatatcagga
    52921 attacttgac gaacacaggg tcgggaatat aaaatacata aaggaagagc taggcgattt
    52981 attattttcg atagtaaatc tagctagatt tttagacata gactcaggag aagccttgaa
    53041 ctgtactaca gaaaaattca taaatagatt tgactttata gaaaagagtg caatgaactt
    53101 gaataaaaaa ttagaagaca tgacacttga agagatggat gagttttgga atcaggctaa
    53161 aaaacaataa aattgtggaa ggaaatttgt caaaaatcta gaacttttat cacaaagata
    53221 gaagtctata ttataaacat ttttaggagg taaatatcgt gaataaagct gaattagtat
    53281 caaagatggc agaaaaaagt ggattaacaa agaaggaagc agaagctgcg ttaaacgcat
    53341 ttatgagttc tgttcaagat gcactagtaa ataatgaaaa agttcaatta gttggatttg
    53401 gaacatttga gacaagagaa agagctgcta gacaaggaag aaatccaaga gatccagagc
    53461 aagttataga tataccagct tctaaagcac cagttttcaa agctggaaaa ggattaaagg
    53521 atataataaa tggataatta gaaatcttgt gaaaaagtgt ggataaattt gccacacttt
    53581 ttctatagaa ccaaggaagg tgataattat gagattagat aaatttttaa aagtatctag
    53641 gattataaaa agaagaactg ttgctaaaga tgcatgtgat aaagggattg tcactataaa
    53701 tggaaaagtt gctaaatctt cttcagaggt gaatattgga gatacattag aaatacaatt
    53761 tggagagaag aagatgaagt ttaagataaa tgaagtaaaa gagcatgtat taaaaaatga
    53821 tgcaaaagaa atgtacgaaa ttttagaata aaattaatag tcctctagta tattaatagt
    53881 agtattattg aaatatttac tggggggata ttatggaaca gaacataact ttgaaagata
    53941 gatcaaagct ggttatttcg ggagtcgagc acatatactc ttttaatgac aaaagagtag
    54001 agctcaaaac ttctgtaggc gagatggtaa ttgaaggcga aaacctagat atgagcaagc
    54061 taagtataga cgaaaatata attagcatag atggaactat aaattctatg gtatatgcaa
    54121 agcctaaaaa gccacaagag agtttcttga aaaaggtatt tagatagatg atacctttta
    54181 ctcaagatgt aagcattttt tatgctacta tttatggtgg aatactcata ggggtgttgt
    54241 ttgattttta tagagggcta agagggaatt ttaaattcat caattatttt gctataatat
    54301 ttgatgtatt gttttggttt ctagctacgg ttataatatt cgtaacaata aaccttacag
    54361 aattttttga tttaagatat tatcattttg tggctttgtt tattggtttt attttatact
    54421 ataacaccat aagtaaaatt gttttatcaa ttatcaataa aataattcgt tttgtgagaa
    54481 attcttttaa aaaagttaca cattacatag tcagtttttt aaataatttg tattacgtta
    54541 taatctattc actacaccta ctatttgata ttatatttta tataccaaac atatttatag
    54601 caacaagaaa aagtataaaa agaaaatcaa ataaaaaatt aaagaacaag aaaaaatcaa
    54661 aacctaagaa gaaaaaaaat aaaactaaaa aaagggtgta ggaaaaatga acttaagaaa
    54721 aaaattttca ggacagatta ttgttatcag tttattttta ggaatatcaa tttttagtat
    54781 gatgacagga tttgtatttg agtatacaaa agctaaggaa tataaaaaag aaatagcaag
    54841 tctaaataaa caattaaaaa agactgaaat acaaataaac agcttaaaga aagatgaaaa
    54901 atcatatgaa ggagacttag aggatatagc aagaaaaaga ttgaatatgg taaaaccaaa
    54961 tgaaacagtt tatgtagaca taaatcgttg attaaaactt gctaataagt ttacagatgt
    55021 attgatttta aaatttaaga tttaataaaa aagtcattca gttaaggatg gctttttgtt
    55081 tttattgagg agggaatttc ataatgaaag taggagctat agatattggg acaaactcaa
    55141 tgagattatt gatagcagat tatagagatg ggaattttat aaacagaaaa aaatttgtta
    55201 atacaactag aattggttat ggtgtggata gtaaaggata tataaaagaa gatgctatca
    55261 aaagaaatat aaaagcatta aaagaatttt ctgataagtg taatgatgaa aagtgtgaaa
    55321 aaatttattg tatggggaca tctgctctta gagacagtaa aaatggagat tactttgtta
    55381 aattagctaa agaagaaact ggaatagatg ttgatatagt tacgggaata gaagaatcaa
    55441 atttgggctt taagggtgtt ttagaaggaa tacaaggtga tgatactatt attgttatag
    55501 atattggagg aggttcaaca gaatttattg taggtgattc agaaggaatt aagtttaata
    55561 aaagtgaaaa tgtaggtgct cttaggatga cagagaggtt tttgaagcac gatcttattg
    55621 aagatgaaga gtttgaagct atgagttcat ttatatatgg tgagattgac aaaacgttaa
    55681 atcatataaa agacagagga ttaaaaactc ttataggtat aggaggtacg attacatcat
    55741 tatcagcaat gaatcaagaa ttagagattt actctatgga aaaaatacat aatagtaaaa
    55801 tacacaaaaa agaaatagaa gaaattctac aaaaattaat aaagatgaca ttaagtgata
    55861 aaaagaactt aaaagggcta caagaaaaac gtgcggatat tataactgct ggtgtaaaaa
    55921 tattgaatat aataatggaa aaattagaaa tagaagaaat aaccgtaagt gaatacgata
    55981 atttggaagg cttaatatgt caaaagtcaa aaaaaatgta ttaatatttt ttgattttta
    56041 aaaccgatta tgacaaaaaa aattactcct ctttgttaca attcttaata taaacaaaag
    56101 aggaggtttt tttatgcaaa gaagtgtagc agttgtgaag aataagactg taaaaccaaa
    56161 tgtcataaaa ttaataagcg gatatattga ttttactacg gcggcattcg ctgtgatggg
    56221 atttttactt agtaggtcta ttatagtaga ctctgtagct cctttaggaa ttgccttttt
    56281 tatatgtgca tcaaagattg ataagtacaa gatacctgta ttcatatcaa cattattagg
    56341 aatattgtta tcatctaatg attttggaaa tgtagcaaaa tatgctgtgt gccttacaat
    56401 atttatggct atgaataaaa aattaaaatt atcagattca attgctaagg ttgcatttat
    56461 aggtgcaata atactacttc caatctccat gggacaagct ttcttttcaa ataggtatgt
    56521 atatggtctt cttatagcag gagtagaatc aataataatg tttatatcta tatatgtgtt
    56581 ttcttatggg ataggtttaa tggccaatgt caacaatagg atgtctgtac ggacagaaga
    56641 agccatatca ataagtttac tgctaacctt tagcataatg ggaataggag atatatctct
    56701 gtttggaata tcaataagga ccattttatc gaccgtattg atattgctga cctcaatagt
    56761 aggtggagct accatgggag catctagtgg tgtaattatt ggtgtagcat ccattttaaa
    56821 taatatgaca tcagctgttt atatggggat atattctttt tcaggattaa taagtggagc
    56881 atttaataaa ataaataaat atttctgtat actaggatat attctaagtt ggacaataat
    56941 atacctatat acttctggta ttacttctaa tatgatgcaa ttaagagata tactattagg
    57001 ttgtttgata gtactagtat tgccagagcg attatttaat aagattgaaa aattaataaa
    57061 aagtaatgtg gcttcaaatg aaatcgtata cgattatatt atgagaagca aaaacctaac
    57121 taatagcaga ttgaacagta tttataaaac ttatgatgac cttgcagata catttgataa
    57181 gataagagaa aaagacaaag tgctagacca aagagacata gctaatgtaa tagatatgat
    57241 tcataatgat gaatgtaaaa gttgtagtat gagaagaatg tgctgggagt caagatttaa
    57301 tcatacatac actatgatat ataacattct tgaaaaaatt gaggagaaag gggagttaag
    57361 tctaaacgat atacctaaaa attttagaaa ggaatgtatg aaaccagagt caatagtgaa
    57421 aatatcaaat cactattaca aaatgtttgt attagattat gattggagtg tgaagttttc
    57481 agaaagtaga aagttaatag caaatcagat aagaagtatt tcaaaatcca ttaaatcctt
    57541 atctcaagat ttagaaggcg acataatgct agatatagaa aaggaaaaaa atatatatga
    57601 acagttagaa agatatgata taacagttga taaagtaagt tacttaacaa aaagtaacag
    57661 tgagtttgaa atatcaatag aaaagaaaac ttgccatgat ggatgtatgt gtgaagataa
    57721 aattgtaaat ataatttcag acctagtagg ggaaaatatg tctgttagaa aaataggatg
    57781 tcactgttta ggaggtaaat gcaaggcaac attcgttaaa tctcaaaaat ataaggctgt
    57841 tacagaagtt tcagcaatgt caagggatgg gcatatcctt tgtggagaca attacacata
    57901 catggagata aatgatggta aatacatgat ggctataagt gatggtatgg gaaaaggtaa
    57961 aaaagcatat gaagaatctt ctgccactat tgatatactg gaaaaaatga tagatgcaaa
    58021 aattaaagat gagatagtca ttgatactat aaataatatg ttgttgttaa agtcttcaga
    58081 agagatgttt tcaactctgg atttgggaat tttagattta aaacgaggtt gtttagaaac
    58141 tataaagatg ggagcgtgtt ctacttatat aaaaagagag gatggagaag ttgacttaat
    58201 atcgtcatca tcattacctg tgggtatatt atcagatgta aaaattgata gaaaaaatgt
    58261 aaaagttaag gaaggagact atgttataat ggtttctgat ggaattgtag atgcaggaag
    58321 aaataacaat ttaggagaca attggttaat atacttctta aagaatatag agactacaaa
    58381 tccaaaggaa atttcaaatt taatattgga tagagcatta gagttacaag cgttacaaat
    58441 tgaagatgac atgactgttt tagttacgaa aatatgtaca aaataaggtt tacaagatta
    58501 tgtgtataag atgtggataa cttgtgtata atatgttaat agacttttga aaaaagtata
    58561 gttattaaca aaaataacat ataaatcaac aaaatttgtt gataagtatg gcagaaatgt
    58621 taataaaatg taaaaaaaga aaaaacaaaa gctattatca aaagagattc atgttgaaat
    58681 aactaaattt ctaagtaaag aaaacctgtg aatatgttga ttattatgtg gataactatt
    58741 aattcgatat ttatttatat agtatgaata attgaataat atatctaaaa aaagccatcc
    58801 tattattaag taaacttatt gaaaggatgg ctttttatga atagaaaatt gtgcaaagca
    58861 ataatacctt tatttatttc tattttttgc atgttaataa taagtataaa agctgaccaa
    58921 ggatatcaaa agaataatga cagagcaatt actgtcatga ataataatga tactgaagat
    58981 gatgctgaaa aaaaacaaga aatagactat gaaaaaacat gttggaattt gcaatctttg
    59041 tttaaaagtg atgaccaatg gaaaaaagaa cttaagagtt ttgataaaga tactaaagag
    59101 ttgaaaaatt acataggtaa agtaacaaaa tcgccaacac atttgtcttt tgccttaaac
    59161 attaaagaaa aacttgatat aagactaaat aaactttctg cctatgtaaa attaaaacaa
    59221 gatactaata aaaattcgta taagtactta gatatgaatg atagtatgag taaatcctat
    59281 gggaattata tggggatttg ttcagattta gagttagaaa tactaaaatt atcaaacaaa
    59341 gattacaaga aaattatttc aaataaaaat ataaatagga aatatggtgc atatttaaga
    59401 gatataagaa ggaataaagt acattatttg gatgataaat cagaagatat tctaagcaaa
    59461 gtatcttcaa taagtagtct tccaagccaa gtgtatgaat tatttagaaa tatggataga
    59521 aaaactaatt tgacaccagc tcaatatgcg agtgaattag agtcatcaga tagagaaaat
    59581 agaaaaaaag cttatcaaga tgaacttata acttacaatg ataatataaa tacaattgca
    59641 ggtttaatta ctggtcaagt taaaaagaat attttttatt ctcaggaaag aggttatgag
    59701 tcttctttag aaatgtacct ggaatctgat aatgtagatg aaaaagtata caataatttg
    59761 ataaggactg taaatagtaa tatggacagt ctacacaaat atatagattt aagaaaaaaa
    59821 gtattaaaat tagataaggt tcattcatat gatatgtttg tgcctatggt taaggctgtt
    59881 gataataata ttaattatga aaaggcacaa agtatagtat attcagcgtt gtcaccttta
    59941 ggaaaagaat acaatgatgt agtatataaa gctttcaatg aaaaatggat agatgtttat
    60001 tcacatgaaa ataaagtaag tggtggatac tgcttatctg tttatgaaaa tcatccatat
    60061 atacttttaa attataataa ttcattaggt tcagtttcga ctttatcaca tgagcttgga
    60121 catgctgtat atgaatattt aagttctaag aatcagaatt attttaattc aaatccgtct
    60181 atatttactc acgaagttgc atctacaacg aatgaagcat tactttacga gatgcttata
    60241 aaagaagcta aaggcaatga tgaaaaagct tattatataa cacagtattt agacttgata
    60301 aaagatactc tttatacaca aactatgtat gctgaatttg aaaaaactat acacgagtta
    60361 gtagaaaaag gaaaaagtgt aaacgcatta gtattaaatg atgtttgggg acaacttctt
    60421 aaaaaatatt atggacaaag ctatgaatta gaccaattat ctaaggtcgg atgggctaga
    60481 atcccacatt tttataatag tttctatgtc tataaatatg ctacaggttg tagtgcagga
    60541 gtaagttttg cccaagacat cctaaagaat ggttcagata actatatgag ctttcttaaa
    60601 aagggaagtt cagattatcc aataaacttg ttaaaatcaa gtggcataaa tttaactaat
    60661 acaaaaccca tagaaaatac aatcaaaaaa tttgatagtt tagtagcaga acttgaaaag
    60721 ctattataaa cattattgta atccacatgg taaatatatc gaattaatga taaaatatac
    60781 taaaagttta aagtcctatc aagataggac tttttattta ttaattagtg ggagatgatt
    60841 ctatgcaagt taaagttaaa aaggctgtaa taccagcagc aggtttagga actagatttt
    60901 tgccagctac aaaggcacaa ccaaaagaga tgttaccaat agttgataag ccaactctac
    60961 aatacataat agaagaagct gtggcctcag gaatagagga aatactaata ataacaggta
    61021 gaaataaaaa atctattgaa gaccactttg ataaatctgt agaattggaa cttgatttag
    61081 agaaaaaagg taagaaagaa ttgttggagg tagtacaaaa catatctaac atgattaaca
    61141 tacattatat aagacaaaaa gagccaaaag ggttgggaga tgcaatttat tgtgcgaggc
    61201 attttatagg tgatgagccg tttgcagtaa tgttagggga tgatattgta gataatgatg
    61261 taccttgtct aaaacaacta acagatgcat atgaggaata tagaactaca atattgggtg
    61321 ttcaaaaggt aaatcaagaa gatactaata aatatgggat aatagaagca aaaaatatag
    61381 aaggtagagt ttacaaggta aaagacatgg tagaaaagcc agagtcagga aaagctcctt
    61441 caaatattgc tattttaggt agatatataa taactcctga aatctttgat attcttaagg
    61501 atttaccacc aggtaaaggt ggagaggtac aacttacaga tgctttaaaa atattatcta
    61561 agaaagaagc tatgtatgca tacaattttg aaggcaagag atatgatgtt ggggacaagc
    61621 taggattttt agaagctact gttgactttg ctctaaagaa agaagacctt aaggaagatt
    61681 ttataaaata tttgaaacat gtatgtagtg aatttgataa aaataacaat gtgttataca
    61741 ataatacaga tgaaaaaata gatttaattg aagtcaatga agctagagaa cttgaaattc
    61801 aaaaataatt aatgaaaggt gatgtatggt ggcaaaatca agtcagaaaa aaattaatag
    61861 aataatagct gttgggattg tgggaatcct cgtaataacg agtataacag ctgttttgag
    61921 tatgattgca actatgtaat aagataaatg acagcagttg atatacataa atataaaaac
    61981 catatataac ttgatgtagt caaaaactta caatatttta gttatatatg gtttttagaa
    62041 tttataaatg taaaaaaaaa tttttataat agttgcatat tttaaaggaa aatattatta
    62101 taagatataa atatagtgat aaatttataa aaacgtgcta agattggact tgaaatacag
    62161 taatatagta ggtaataatg ttttaaattt tatttattga ccataatata taaataatga
    62221 tattattaga cttaactgtt taaataaaac ttttcttttt catgccttca atttccaaaa
    62281 taagtatgta tataaatgaa tatatagatg aggaggattt ttttgatttt agatgataaa
    62341 gtattagaag gattaggtag taagacctta gttgagctac gagagatagc taaagaatta
    62401 aaaataaaat caattactac atataagaaa aatgagttaa ttgagattat aaattccaaa
    62461 agtaaaaatg aggaaaaagt aaacgaagag actaaagaaa aaaatgaaga tattaaagaa
    62521 gacataaaga atagaaaaga aaatatagag cgtgaaagta tagaaaaaga agttgaatat
    62581 aagagcccta ccaaatcata caacaagaaa gaaatagata cccaaaatat ttcccaaaac
    62641 caagaacata gaaatcaaag aaatgactat aataagacaa cgagtgtaaa tgatagcaat
    62701 aagtcatcaa atatatctaa tagaatggtc agaaataata ataaaaacta ttatatgcct
    62761 aaacaagttg atgaatctaa gatagtagat gaatttaaca catcaaaaga ggatgaagta
    62821 gtaggtgtac ttgaaattct gccagatgga tttggttttt taagaggttc aaattatttg
    62881 tctactgaag gagatgttta cgtttcacca tctcaaataa gaagatttaa tatgaaaaca
    62941 ggagacaaga ttaagggaat aactagacat ccaaaaagtg gagagaaatt tagagcactt
    63001 ttatatgttc aaaaaataaa tgatgaaaac cctgacacag ctatacaaag aaatgcgttt
    63061 gagacattaa caccaatatt tccagaagaa cgacttacac tggaaactaa tagaaatgaa
    63121 atagctacaa gaattataga tttaatttca cctataggaa aaggacaaag aggattgata
    63181 gtagcacctc caaaagctgg gaaaacagtt cttttaaaaa gcgttgcaaa tagcatagct
    63241 aaaaatcatc caaatgttga acttatagta ctccttatag atgaaagacc agaggaagtt
    63301 actgatatga aagaatctat tgaaggagac gttatatatt ccacttttga ccaagtatca
    63361 agtcatcatg tcaaggttgc agagatggtg ttaaatagag ctcaaagatt agttgaacat
    63421 ggtaaagatg tagtaatttt actagatagt ataactagat tggcaagggc atataacctt
    63481 acaatatctc ctacaggtag aactttatct ggaggtattg accctggtgc acttcatgga
    63541 cctaaaaagt tctttggtgc agcaaggaat attagacagg gtggttcttt gacaatatta
    63601 ggaacagcat tggttgaaac tggttctagg atggatgatg taatatttga ggaatttaaa
    63661 ggtacaggaa atatggagct acatttagat agaaaattag cagaaaaaag aatattccct
    63721 gcaatagata tttacaagtc tggtacaaga agagatgatt tattgcttga tgatgaagaa
    63781 aagactgctc tttggagatt aagaagagaa atgagtaata attcagtaat ggaaattaca
    63841 gataaagtca ttgaacttat aaagagaact aaggacaata aagagtttgt aaaatcaata
    63901 aagaatttgt aaaatcaata atacaaatgc aaatatggat tatataaact aatagaaaaa
    63961 tcacttgaat ggcataataa gttgtgctat aataatgtag ttgataatgt aaaaagaaag
    64021 ttaatataat taattttttt aaataaagag aagaggtgac tataatgcaa aaggaaatac
    64081 aaccaaaata caatccagtt gaagtgcgtt gtgcttgtgg gaacacattt gttgctggtt
    64141 caactaagga cgaaataaaa gttgaaatat gttcagagtg ccatccattc tatacaggaa
    64201 aacaaaagaa catagaaaaa ggtggaagaa tcgacaaatt caagaaaaga ttcaaaatgg
    64261 actaattttt ataaaagtgg agttggagga agccaactcc tattttatta caaaaaaaca
    64321 ttcatattct actttaaatt gtctttttgt attataataa taaatatgta aaattgagta
    64381 ttctaaatac aataaaatga ggtgagtgga tggcaaaaca agctgtaggt gggcaagctg
    64441 ttattgaagg tgtaatgatg cagtcaaaag acaaaagagc ggtagctgtt agaaaaagtg
    64501 acggagaaat agcactaaaa gaagatagaa taaaaagttg ggtaagagat aagaatatag
    64561 ataagatacc ttttgttaga ggttcttttg ttatgataga tacaatgatt caaggcataa
    64621 aaagtttaaa cttttcttca gagtttttta tggaagaagc tgaagaggat aaatttgatt
    64681 tatttataaa gaaaattttt aaagataagg caaatgatat aattataata ttttcattgg
    64741 tcatagcaat gttactttct gctggattat tcatttttat acctacattg gtaggaggag
    64801 ctttttctaa agtaatgcct aatgatttta tgcttaattt aatagaagga atcataagga
    64861 tagctatatt atttgcatat atagtattga tttcacgaag taaggatata gaaagagtct
    64921 ttcaatatca tggagcagaa cataaatcta tatattgcta tgaaaatgat ttagaactta
    64981 cagtagagaa tgctagaaaa tttaaaagat tacatcctag atgtggtaca aatttcctat
    65041 ttatagttat ggctgtatca ataatattgt ttgcattttt tggttggcca aatccaattc
    65101 ttagaatatt tatgagaatt atatgtgtgc ctatagtagc aggtttatct tatgaggtaa
    65161 ttagagttct tgggaaatat gataatggat ttactaaaat tattgcatat ccaggaatga
    65221 tgttgcaata ttttacaaca aaagagcctg atgatgagca attagaggtt gctttggaag
    65281 cattgaaagc agtagtagat tagagaaaag gatatttgtt atgacgataa aagatataat
    65341 tattaaatat tcagataaac taaaagatat aagtgatact ccaagattag atacagagtt
    65401 attgttacaa aaaacattgg gtgttgatag attatatatt cacttaaatc tgaataaaga
    65461 gctaactgaa gaacaaaaaa caaaatttat gggttttgca gaagaaagat taaatggaag
    65521 accaatagca tatatagttg aaaataggga gtttatggga ttagattttt ttgttaagga
    65581 aggcgtattg attccaagac cagatacaga aactttagta gaagaaataa ttgaaatatg
    65641 tagagaaaaa aaagatgtaa gtatattaga tataggaact ggttctggag ctattacaat
    65701 aagtttagca aagtacattg aaaattctaa aatcatgtct tttgatatat cagagacagc
    65761 attagaaata gctaaaaaaa atgctattat aaatgaagtt ggtgaaaaaa taaagtatat
    65821 taattctgat ttatttacag caataagtga tagtaacata aaattcgata tcatagtttc
    65881 aaatccacca tatattaaaa aacaagatat agaaactctg cacaaacaag ttaaagatta
    65941 tgaaccatat aatgctcttg aaggtggaga agatggatta gacttttata gaagaataac
    66001 agaacaaggt aagaaatatt taaataagtg tggaatatta gcatatgaag ttggtcataa
    66061 tcaagctgaa gatgtaataa atattatgaa aagtaatgga tataaaaaaa tatacacaaa
    66121 gaaggatatt caaggcattg atagagttgt tataggttac aatatatgat ataatcaaca
    66181 attgatatgt tacatttaat cgaggtgaaa gtatgttaaa aaaattagag gtattggaag
    66241 atacatataa agacttaagt gaaaaaatag gtgatccgga tgtaataaat gatcaaaaag
    66301 tttggcagaa atatataaaa gaacatgctg acttggaacc tattgttatg aaatacagag
    66361 agtataaaag cgttttagat agtataaaag aatcaaaaga aattttacaa gaagagtcag
    66421 atgaagaatt aagagaatta gctaaaatgg agttagctga gatggaagaa aaagtagcac
    66481 ctctggagga agaaataaaa atactattat tgcctaaaga ccctaatgat gataagaacg
    66541 ttatagttga aattagaggt ggagctggag gagatgaagc agctctattt gctggtgatt
    66601 tatttagaat gtactcaagg tatgctgaaa gaagaagatg gaaaatagaa ttattgagtg
    66661 caagtgatac tggagttggt ggatataaag aagtatcttt tatgataaaa ggtaaaggtg
    66721 cttattcaag attaaagtat gaatctggag ttcatagagt tcaaagaata ccatcaactg
    66781 aatctggtgg aagaatacac acatcaactt ctactgttgc agtattacca gaagttgaag
    66841 atgtagaggt tgaaataaat ccaaatgatt taagaataga tgttttccgt tcttcgggta
    66901 atggaggaca aagtgtcaat actactgact ctgctgttag ggtaacacat atacctacag
    66961 gtgaagtagt atcttgtcaa gatggaaaat cacaattaaa aaataaagag caagctttaa
    67021 aaatattaaa agctagactt tacgataaag cattggcaga acaacacaaa gatatagcag
    67081 cagaaagaaa aagccaagtc ggaacaggag acaggtcaga aagaataaga acatataatt
    67141 tccctcaagg tagaataagt gaccatagaa taaatttaac tttatataag ttagatgcat
    67201 tcttagatgg agatatagat gaaatgatag atgctttaat tactgttgac caaacagaaa
    67261 aaatgactgc aatataagta atgttttaaa gaagctgttt cttcctagaa attattttct
    67321 attttgaaac agctattttg cattttaggt catgttatca tattctattg tatataattg
    67381 ttatatacaa gtataggagg gttatatgat actaaaagta acaataattg ggcttttggc
    67441 aggtgttata gggacaggat taggaggagt aatatcagcc atttttaaaa gagaggtcga
    67501 taaatatcta agttttttta tgggattatc tggtggaata atgttggctg tagtggtgtt
    67561 tgatttaatg aaagaatcca tggacaaaat ggggataatc aatacagtta tatttacgtt
    67621 tgttggagct ctcataacta tgtacataaa aacaaaatta gatgtgtctg gaaatatggc
    67681 atctggatat cttatattca taagtatatt actacataat ttaccagaag gactagccat
    67741 tggttcttct tttatgtcaa ctgaaagttt aggtattaca cttgctatag ttataggtct
    67801 acataatata ccagaagggt tagctatggc attaggctta gtttgcaata aaatgaaact
    67861 aagtaaagtt attttgttta ctgtaatagc tggattacct atgggtctag gaagtttttt
    67921 aggtgtttat tttggaggag tatttacttc tcttatagga gtatttcttg ctacagcagg
    67981 aggtactatg atgtatgttg tattggaaga aatttttcca cattcaaaaa gtgtgtattg
    68041 tataattggt ttcttgttag gtacaatgat tgtaaattat atataaaatt aaaatgaaag
    68101 caggcataca aaagatgaaa actattataa gtaatattga tataaataat attgattatg
    68161 aggaaataaa aatacaagca aaacttctta gagaaggtaa aacagttatt tttccaactg
    68221 agacagtata tgggttgggt gcaaatgcat tagatgaaaa tgcagtaaag aagatttatg
    68281 aagctaaagg aagacctagt gacaatccat tgatagtcca tatatatgaa aaagaagaag
    68341 tatatgactt agccaaagat ataagtgata aagctaaact tgttatagaa aagctttggc
    68401 caggacctat aacaattata ttaaataaaa aagatataat tccatacaaa actagtggag
    68461 ggcttgatac agttgcaata aggatgcctt ctaatgttat tgccagggca ataataaaag
    68521 aagctggtat acctattgca gctccttctg caaatatctc aggtcgccca tctccaacaa
    68581 aagcaaaaca tgtatatgaa gagatgaatg gaagagtgga tggaatagtt ttaggaggag
    68641 acagtaattt tggattggag tcaactgtat tggatttaac agaagagact cctatgatac
    68701 tgagaccagg aagtataact aaagaagttt tagaggaact tcttggagaa gtaaagcttg
    68761 acccatcatt aagtaaaaaa gaagataatc aaaaagctaa agctcctgga atgaaatata
    68821 aacattattc tccaaatgca gatgtatata taatatctgg aaaaagagaa aatgtagcaa
    68881 caaagattaa tgatatgata aaatctaata gagacaaagg tctaaagaca ggtgtaatgt
    68941 gtattagtag aaaccgagag ttttatgatg gagaagtaat cgatttagga aactctcttg
    69001 aagaagttgc aagtaatctg tttgatgctc ttatagaaat ggacaaaaag ggtgttgatg
    69061 tcatatattc agaagagttc cctaagactg gagttggaca agcaattatg aatagactac
    69121 tgaagtcagc aggatacaaa gtgataaagg cttaagaggg agttgtaaaa tatgaatata
    69181 cttattgtgt gtacaggtaa tacttgtaga agtcctatgg ctgaggctat actaaggaaa
    69241 gcaattaaag aatctggaag aagtattgaa gaatattcta tatcatcagc aggtatatct
    69301 acagcaaatg gaatgggtgc ttctgaaaat tctatagaag tactaaaaga aatcggtata
    69361 gacttatcaa atcatagaag taaagtaatt actaaaaaat taattgatga atcagatata
    69421 atactaacaa tgactaaatc tcataaagaa attttagtac aagcagttcc aaaatgcaaa
    69481 gaaaaagtgt atacttttaa agggtttgca aataaaaatg aggaagatat atctgaccca
    69541 tttggtggaa atttggatat ttatagaagc actatgagag aaataatgta ttctgtcaac
    69601 gaaatagtaa aaaaaatatg aaacggagga taaacaaatg aagataggat taggctgtga
    69661 ccatggagga tataatttaa aaaaagaaat aataagctat ttagaaagta aaggtataga
    69721 atgtgtagat tacggaacta ataatgctac agattctgtt gattatcctg tttatggaga
    69781 aatagttgca aattcagtta taaataaaga agtagattat ggaatattat gttgtggtac
    69841 agggatagga atatctttag ctgctaataa ggttcctggg ataagatgtg cagttgtatc
    69901 agatgtattt tctgcaaaaa tgtcaaaagc acataatgat gcaaatatgt tatcattagg
    69961 cgaaagagtt ttaggaaaag gtctagcact tgagatagtt gaagcatgga ttaatacgga
    70021 ttttgaaggt gatagacatg ctagaagagt aaacatgatt aaatcaatag aagaaaaaca
    70081 taataaataa taaaaattac agttttatca ggaggaatta tcaaaatgag caaagtggta
    70141 gagacaaacc atccattaat acaacataaa ttaactttaa tgagagataa aaatactggt
    70201 tctaaagact ttagagagct tttaactgaa attgcaatgt taatggggta tgaaataaca
    70261 aaagatatac cattaaaaga tgtagaaata gaaactccta ttcaaaaaac atcatctaaa
    70321 gtagttgcag gtaaaaaatt agcaataatt ccaattttaa gagcaggtct tggaatggta
    70381 gatggattag tgagcttaat gccagcagca aaagttggac atgtaggact atatagagac
    70441 ccagaaacat taaaaccagt tgaatattat tgtaagcttc ctcaagacat aggagaaaga
    70501 gatataatag tagttgaccc tatgcttgca acagggggtt ctgctgtagc agctatagat
    70561 ttacttaagt ctaaaggagc taaaagtata aaattagcta atttagtagc tgcaccagaa
    70621 ggtatagcag aagtgcaaaa atatcatgat gatgttgata tatatgttgc atcagttgac
    70681 gaaagattaa atgaacatgg atatataatt cctggtcttg gtgatgctgg agatagattg
    70741 tttggaacta aataaaaata aataactata aatatttatt agggactttc ttatatagtg
    70801 tatataattt tatgtaagaa ggttcttttt tatatatttt ttctcaaaat aggaattatt
    70861 gaattgataa atttctcgaa ttgagaataa aaagttttta ccaattaaaa aagattgctt
    70921 attttacaag gttttataga atagtagtct attttaatgt ggcatgttag ttgcttacga
    70981 ttaagattat aggtattaag tgtattagtt aaattgagaa ttgaatatta ataatattat
    71041 tgggagtggt aatacatgaa gaattgtata gtagtaagag gggctggaga tttagcaaca
    71101 gcagttattc ataaattaca caacagtggt tttaaagtag ttgcgttaga aatagaagag
    71161 ccattagcta taagaaggca aatttctttt tgtgaggctg tttatgaaaa aaaagtaact
    71221 gttgaaggtg tagaatgtat attttgcaat actgaaaaag aaatagaaga agttttatct
    71281 caacataaag tagccttgat tatagaccca aaaggagaaa aattatctaa attaaatcca
    71341 atcgttttgg ttgatggaat actcgctaag aaaaacttag gtacaactaa agatatggca
    71401 ccacttacaa tagctttagg tcctggattt tgtgcaggag aagatgtaga tgttgttata
    71461 gagacaatga gaggtcataa tctaggaaga ataataacta atggtagagc agaaaaaaat
    71521 acaggagtac caggagcaat aaaaggtttt tctaaagaga gagttatgca ttcacagtat
    71581 gatggcataa tggaaaatgt atgtaagata ggtgatatag ttgaaaaggg agacctactt
    71641 tgctatatta ataattatga aaaaaaacat gaagttagag caacaatatc tggagtcctt
    71701 agaggtttat taaaggatgg agcaaaggta aacaaaaatt taaaaatact agacatagac
    71761 cctagaaaag aagaagttaa gaatgctttt acaatatcag ataaagctag atgcatagct
    71821 ggaggggttt tagaagccat actaaacaat gggatttatc cccaaaatta atttatatta
    71881 gataaagcta ttaatatttt attaagatga tataataaat ttaatagatt aaagagagca
    71941 tatgacgggt atttaaaatt taaatggtaa aaatgctctt tttttattgg acattcaatt
    72001 aacatgtgta tataatataa aaataagtat ttatttaggt tgaaatctaa taaatatata
    72061 ataccagtac ataagcaaag aggagaaaag taaattatga gaccatcatg ggatgaatac
    72121 ttcatggaaa ttgcagaagt agtgaaaaag cgttcaactt gtattagaag acaagtagga
    72181 gctgtaattg taagagacaa acaaatatta acaactggat ataatggttc tccgagaaat
    72241 cttgaacact gtgaaaatat tggatgtaag aggcaggaat taaatattcc ctcaggagaa
    72301 aggcatgaat tatgcagagc attacatgct gaacaaaatg cgataataca agctgctcat
    72361 aatggtatta gtgtagatgg ggcaactttg tatgttacta caagaccttg tgttttgtgt
    72421 gcaaaaatgt gcataaatgc aggtatattg aaaattgttt atgaaggtga ttatccagat
    72481 gatatgtcta cagaattatt aaaagaagca ggaatagaac tcataaaatt ttagtggata
    72541 aaatttataa gacaataaat gtcaaattat gacactgaaa tacaatggta tcaaatgatt
    72601 aaaagaaagt atttgaaaaa tcatcagatt agtagtaaga tatattttat aattaaataa
    72661 atttatgaga tagattaatt acatgttatt tattttataa taatgaggga tactatttat
    72721 gagtaaaaga aatacacata cagaaattgc aaagttgttt agtttaataa gtcaaatagg
    72781 attgatgatt gtaatatcaa tattaggatg tactttctta ggaaaatttt tagatagtaa
    72841 attgaatact actccagttc tgacaataat atttttattg ttgggtgttg gaggtgcttt
    72901 tagtggtgtt tataaaactc taatagtata tacacgaagg aagtgatata ttggatataa
    72961 aattacttaa ccaggtaagg tcagtaacaa aaggtatagt aatatttgat gtagttttaa
    73021 ttgtgctaat gttgataaca tcaacattaa gtaaaccagt attattagga cttatatttg
    73081 gctctataat agctatgtta aattttagat tattggcgat atcactggaa aaatcagtga
    73141 catttcctgc tgggaaggca caagcttatg catcagcaca atatgctgtt agattattta
    73201 taatggcagt tgttctaatt gcatcagcta cagtaccaca tttaaatata atcggaacag
    73261 cattgggatt attgagcaca aagtttgtca tattatcaaa aaactttata aataaattaa
    73321 agaggaagga ggcataagta tgaatcaagc gcattattat ctcataggaa actttaagat
    73381 tagtgaaaca atactagtaa gttggggaat aatggccttt ttagcgatag catcttattt
    73441 tttgactaga aacttaaaaa aagttccaac tagtaaagtt caaatattct tagaatttgc
    73501 agtaggtggt cttgctaaaa tggttacaga tgttatgggt aaaaatacag taaaaagaat
    73561 gccatatatg ataccataca taggaagctt gtttttattt ttcgcatgtt caaatttaag
    73621 cccattactt ggattaaggt caccaacaac cgacttagac acaactgctg catgggcaat
    73681 gattacattt tttatgattt attttgcagg agttaaattt aaggggttat catactttaa
    73741 agaattggct caaccacttg ccataatgtt accaatcaat attataggtg agttagctag
    73801 accaatatca ttaagtttcc gtccatttgg gaatatttta ggtggaacaa taataatggg
    73861 tctgttttat caacttttag gttttatatc tagtttaata ccaggattat caataccaat
    73921 tggagaaata ttaataccag tcccattaca cttgtacttt gacttatttg caggattgtt
    73981 acaagcatat atatttataa tgttaacaat ggtatttata tcaagtgcag gagagttaga
    74041 ttaagaaatc aacttatatt aagataaaaa taaaataatt taaaaaatta aagttttaag
    74101 gaggaaataa ttatggaaac agcaatagta gcggcagcat cagcaatagg agcagggata
    74161 gcagttgcaa caggtatagg tgcaggtata ggtcaaggta tagcagcagc taaagctgca
    74221 gaagcagtag gaaaccagcc agaagctaaa ggtgatataa catcaacttt attactagga
    74281 gttgctatag cagagtcttc agcaatatat ggtttggtta tatcaataat acttctattc
    74341 gtaaatccat tctttaaata cttaggaatg tagatttagt ccttaaatat tttgagatag
    74401 gtttataggt aaatcatctc aaacttataa tcatgagatg aactttatca tctcgtgatt
    74461 ataagtagtt atgatttatg gaaaggagga taattatgga aaaagcacta gtaggtataa
    74521 cgtgggaatt tgtgttccaa attgttaata cttttataat atttttactt ctgagaaagc
    74581 ttttattcaa gccagtatta aatataattg aatcaagaga aaatgatatt aaaagtgatt
    74641 tggcagaagg cgaaaaagca aaaaatgaag gtttagctct gaaaaaagaa tatgagtcaa
    74701 aaatcaattt tgccaaagat gaaggtcaag aaatcataaa acaagcaact ataagagcag
    74761 agcagaaatc agatgatata gtaaatactg caaagaaaga tgctcttgat ataaaagaaa
    74821 aagcaaacaa agatatagaa caagaaagac aaaaggttat aaatgaaatc aaaaatgata
    74881 tatctaacat agcactactt gcagcatcta aagttattga aaaagattta gataaatcta
    74941 aacatgaaga attgatagaa aactttataa aagaggtagg ggaagctaaa tgataaatgt
    75001 aatagcaaat agatatgccg aagccctatt tcaattagga gaagaagaaa attcaactga
    75061 tgtcttattc aaagaactag aaaaagtagt agatatgatg actaaagtta gtaaagattt
    75121 ctacaaagtt ttaaaatcac cattagtttc aaaatcagaa aagaaaaact tggtagaaat
    75181 tatttttagt aaggaagtaa gttctaacat aaaaaacttt ttaaaagttt tagtagataa
    75241 agatagaata tcatatttag aagatatcga attagcttat aaagaattat taaataagaa
    75301 aaacaatgta attgatggag tagcaataag tgctattcca atgagtgaaa cagatattaa
    75361 agaacttgaa gtcaaacttt caaataaata caacaaaaat gttactatag aaaatgttgt
    75421 tgacaagact atactagggg gagttctagt tagaattgga aatgaacaaa tagatggcac
    75481 tgtgaaaact cgtcttgata agatgaaaga aaagctatct gaagtaatat cttaagaatg
    75541 gcggtgaacc catgaactta aaacctgaag aaataagttc tataattaaa cagcaaataa
    75601 aaaattatga gaataaagtt gagttgacag atacaggtag tgttttaaca gttggggatg
    75661 gtatagcgag tgtatatgga ttagaaaaag ctatgtctgg tgagttgcta gagttcccag
    75721 gtgaaatata tggtatggca cttaacttgg aagaagaagt agttggagct gttatccttg
    75781 gagatgacag tgaaataaaa gaaggcgata tagttaagag aactggaaga atagttgaag
    75841 ttccagttgg agaagcttta ataggtagag ttgtaaactc attaggtcag ccaatagatg
    75901 gaaaaggacc tatagcgtac acaaaaacta gaccagttga atctgaggca cctggtataa
    75961 tagatagaag gtctgtttat gaaccattac aaacaggaat caaatcaata gattcaatga
    76021 taccaattgg tagaggtcaa agagagttaa taataggtga cagacaaact ggtaaaacat
    76081 ctatagttat tgacactata ctaaatcaaa aaggaaaaga tgttatctgt atatatgtag
    76141 caattggaca aaaacgttct actatagctc aattagttag ctctttagaa aaaggtggag
    76201 ctttggatta tacaatagta gtttcagcaa cagcatctga atcagcacca cttcaatata
    76261 tagcaccata tgctggagca gctatgggtg aagaatttat gtacaatggg aaacatgtac
    76321 ttatagtgta tgatgattta agtaaacaag ctgttgcata tagagaaatg tcattgttac
    76381 ttagaagacc accaggacgt gaggcatatc ctggagatgt attctattta cattcaagat
    76441 tacttgaaag agcagctaag ttatctgatg aattgggtgg aggttcaatg actgccttgc
    76501 ctataataga aactcaagct ggtgacgttt ctgcatatat accaacaaat gttatatcta
    76561 taacagatgg tcaaatatac ttacaaccag agttattcta ttcaggtgta agaccagcag
    76621 ttgaccctgg tatatcagta tcaagggttg gtggttctgc gcaaattaaa gcaatgaaaa
    76681 aagttgcagg aacattaaaa cttgcatatt cacaatatag agaacttgca gcattctcac
    76741 agtttggttc tgacttagat gaagatacta aaaagagact tgctcaaggt gaaagaatcg
    76801 ttgagatatt aaaacaaggt gagcatcaac caataaaagt tgaaaatcaa gttatgataa
    76861 tatatgctgt tataaataat catttagagg atattccgat agataatata gctagatttg
    76921 aatcagaatt gtatgcattt gtagataata attatccgga aatatcaaga aaaatattag
    76981 gtggagaaga cttcactcat gatttaacag atgcaataaa tgaatttaaa gaaaagtttg
    77041 ttgttgaagt ataatccttt ttaaaaaagg aggtaaatta attggcagga gctggaatca
    77101 aagcaatcaa aacacgtatg ggaactgttg aaagtacaaa gcaaataact aaagcaatgg
    77161 aattagttgc atcttctaag cttagaaaag caaaagaaaa ggctgaagat tcaagagaat
    77221 attttaatac tttatacaat acagtaaaag atattgccca aacaacacgt ggaattagaa
    77281 atgaattttt aaaagaaaga gaagtaaaaa ataaatgcta tgtagtagta gctggagaca
    77341 gaggacttgc aggtggatac aattctaatg tattaaagga atctgtctct catatgaaag
    77401 gtaaaaagga aacagtgatt actgttggaa agaaagcaca tgaatttttt tctaaaagaa
    77461 actacaatat agcaaaagat ataaatagtg ttgaagcttg tggatatgaa gatgcgacag
    77521 aaatttcaca aactattatt gacctgtata aaaaaggtga agtagatgaa gtttatattg
    77581 cttatacaaa atttaaatct gctttatcac aagaagttga aattttgaaa ttgcttccat
    77641 tagtctttga aaaagataca gacgaacaag gaatggcagt aaaagaagaa aaacaaaata
    77701 gatcaaaagt acaatatata ccatcagcag aagcagtttt aagttatatt gtacctcagt
    77761 ttatatcagg tacagtatat ggtggaattt tggaatcttt tgcatcagag caaggtgcta
    77821 gaagaactgc aatggaatca gccacagaca atgcgaatga aatgctatct aatttagagt
    77881 taagttataa cagagcaaga cagtcagctg taactcaaga aataacagag atagttggtg
    77941 gagttgaagc tctaaaatag ggaggttagg aaatggcaaa tgtaggtaaa gtagtacaga
    78001 ttgtaggagc tgtactagat gttaagtttg atggtgaaca aagcctacct aacttattaa
    78061 atgcgttagt aataaagtta ggagataaag aaatagttgc agaagttgct caacatatag
    78121 gtgatgatac tgtaagatgt atagctatga gtgcaacaga cggacttgta agaggtatgg
    78181 aagttgtaga tacaggaggg ccaataagtg ttcctgttgg agatgagact ttaggtagaa
    78241 tattcaatgt tcttggaaaa ccagttgatg ggaaaccagc tccaaaatct gcacctaaat
    78301 tacctataca tagaccagca ccggcgtatg atgaactaga aactacagca gagatactag
    78361 aaactggtat taaggtagtt gacttactag ctccatatct aaaaggtgga aaaataggtc
    78421 tatttggagg agcaggagta ggaaagacag ttctaataca agagcttata aacaatattg
    78481 ctaagcaaca tggtggtatt tctgtatttt caggagtagg agaaagaaca agagaaggta
    78541 acgaccttta tggcgaaatg agtgagtctg gagttataaa taaaacagct ctagtatttg
    78601 gtcaaatgaa tgaaccacct ggagcgagaa tgagagttgc tttaactgga cttacaatgg
    78661 cagaacattt tagagatgag caaggacaag acgttttact tttcgttgat aatatattcc
    78721 gtttcacaca agctggttca gaagtttcag cacttctagg acgtatgcca tcagctgttg
    78781 gttatcagcc aacattagct actgaaatgg gtgcacttca agagagaata acatcaacta
    78841 agaaaggttc aataacatct gttcaagcag tatatgtacc agcagatgac ttaactgacc
    78901 cagcaccagc tacaacattc tctcacttag atgcaaaaac agttttatca agacaaatat
    78961 catcactggg tatatatcca gcagttgacc ctcttgaatc tacatcaagg attcttgacc
    79021 ctagtatagt aggaaaagaa cattatgaag tagctagagg tgtacaatca atacttcaaa
    79081 gatataaaga acttcaagat ataattgcta tacttggtat ggatgaatta tctgatgaag
    79141 ataagttaat agttgcacgt gctagaaaga tacaaagatt cttatctcaa tcattcacag
    79201 ttgctgagca atttacagga aatccaggtc aatatgtacc tgttaaagag actgtaagag
    79261 gatttaaaga aattcttgaa gggaaacatg atgacttacc agagtcagca ttcttatttg
    79321 taggaacaat agaagacgct gttagaaaag cgaagggaag tatgtagtca tggccagtga
    79381 attttcattg aaagttgtaa ctccaagtaa tactttttat gatggagatg ttgaaatgat
    79441 agtagttaga actacaaaag gagacaaagg ggtgttgaaa ggtcatatac catttgtttc
    79501 aggtatacct gtaggaactt taaagataaa aaaagaggga agttttaaag aggcgaaaat
    79561 agcagaagga ttcattaatg taactcaaga taaaactgtc atattaacag aatctgctga
    79621 gtggatttaa taaattaatt tagagtataa aaagtcattt tgaccaaaaa aacttttggg
    79681 taaaatggct tttttgtgtt ttggtgttaa taaaataacg ataaaattgt aagtttttag
    79741 tgataataaa ttcacaaaat gtttaaattt actgccaaat tatgttgtaa ttaataagat
    79801 aaagaagatt tagatagctt ttatgtaagt gaaaaagtct tcatataaga aatacatata
    79861 aaatttttat aaaatttaaa aaatttgctt agttgtgtag tataataaat aatataatag
    79921 atttgtatat aatattcatt acaaataa
//
LOCUS       DAEQCW010000005        78811 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.005, whole genome shotgun sequence.
ACCESSION   DAEQCW010000005 DAEQCW010000000
VERSION     DAEQCW010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 78811)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 78811)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..78811
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.005"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(72..845)
                     /locus_tag="KRO40_000331"
     CDS             complement(72..845)
                     /locus_tag="KRO40_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="HBH2091174.1"
                     /translation="MKNVANATHYLNMDTKELFNLYNKNKNVDIRNILIERHLYLARL
                     LAKKYINKGVDFEDIYQVASLALIYAIDRYDVEKGFEFSSFATPTIVGEIKKYFRDKV
                     WTLRVPRRIQELSKKISDAKIKLEQENKKHPKVKDIADYIGVSEEDVLEAMEASYGYQ
                     PMSLDSSSNDDSEDKDITLIDKIGKEEGNFGSIEYEDFINKFIETLNELEVKIFKDRF
                     FFDKTQSSIAKELGISQMTVSRLEKKVVEKLKKEYEKNL"
     gene            complement(845..1231)
                     /locus_tag="KRO40_000332"
     CDS             complement(845..1231)
                     /locus_tag="KRO40_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2091175.1"
                     /translation="MEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTN
                     AIKHSKDDVFNIVFNILDNAINIEIQDNGKGYDVSSISTPDLENPKESGLGLFIIKTL
                     MDDVDIESEHNQGTKIKMTKYLGVDI"
     gene            complement(1256..1573)
                     /locus_tag="KRO40_000333"
     CDS             complement(1256..1573)
                     /locus_tag="KRO40_000333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STAS domain-containing protein"
                     /protein_id="HBH2091176.1"
                     /translation="MSMNIDSNLDSQNKFWNVCLDGELDVSTADKLKEHLHALIEKNM
                     LDVKINLKDLDYIDSTGLGAMIGVLKKLKINEKEIYIVNPKSNVRKIFTITGLDKIFK
                     VEG"
     gene            complement(1585..1845)
                     /locus_tag="KRO40_000334"
     CDS             complement(1585..1845)
                     /locus_tag="KRO40_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HBH2091177.1"
                     /translation="MNAWGWQIGAVLVGSSALIVAIYLAKTLNSINKVVEKAYKIVDY
                     NERHIQDIVENASSISKGIDDIVYVINKILSIGNIFKIIKRK"
     gene            complement(1845..2141)
                     /locus_tag="KRO40_000335"
     CDS             complement(1845..2141)
                     /locus_tag="KRO40_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH2091178.1"
                     /translation="MCNKRSCKKGGFLLLGAILGFIFGMFFAPKKGSELRKETKEKFN
                     DVKENPKEVLHETFNDVKERIINLVDDDNNEEDIKISEEDIVISKSFDDEGDVN"
     gene            complement(2210..4636)
                     /gene="gyrA"
                     /locus_tag="KRO40_000336"
     CDS             complement(2210..4636)
                     /gene="gyrA"
                     /locus_tag="KRO40_000336"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HBH2091179.1"
                     /translation="MEENNKILPIEIAEEMKKSYIDYSMSVIAGRALPDVRDGLKPVH
                     RRILYSMSELNLTPDKPYRKSARIVGDVLGKYHPHGDTAVYYAMVRMAQDFSTRALLV
                     DGHGNFGSVDGDSPAAMRYTEAKMSKLSLELLRDIEKETVDFKPNFDESLKEPSVLPA
                     RYPNLLVNGSNGIAVGMATSIPPHNLAEVIDATVYLIDNPECSVDDLIKFVQGPDFPT
                     AAIIMGKESIAEAYRTGRGKVKVRSRAFIEELPKGKQQIIVTEIPYQVNKAKLVERIA
                     ELVKEKRIEGISDLRDESNRNGMRIVIELKRDANANIVLNNLYKHSQMEDTFSIIMLA
                     LVDGQPRVLNLKQILYHYIKHQEDVVTRRTKFELNKAEARAHILEGLKIALDNIDAVI
                     SLIRASKTGQEAKLGLIEKFKLTEIQAQAILDMRLQRLTGLERDKIEAEYEDLIKKIN
                     RLKEILADERLLLNVIKDEITIIKENYSDERRTEIRHAEGEIDMRDLISDEEIAITLT
                     HFGYIKRLPSDTYKSQKRGGRGISALTTREEDFVRHLVTTTTHSRLLFFTNKGRVFKL
                     NAYEIPEGKRQAKGTAIVNLLQLSADEKIATLIPIDGNDENEYLLLATKKGIVKKTKR
                     EEFKNINKSGLIAIGLRDDDELIGVELTDGKQEVLLVTKEGMSIRFDENDIRYMGRTA
                     MGVKGITLSKEDFVVSMNLCSKGTDVLVVSKNGFGKRTNIEEYRSQIRAGKGIKTYNI
                     SEKTGTIVGADMVNEDDEIMIINSDGVLIRIRVNEISLFGRVTSGVKLMKTNDEVNVV
                     SIAKINIEEE"
     gene            complement(4656..6557)
                     /gene="gyrB"
                     /locus_tag="KRO40_000337"
     CDS             complement(4656..6557)
                     /gene="gyrB"
                     /locus_tag="KRO40_000337"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003226808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HBH2091180.1"
                     /translation="MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVD
                     NSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVEIHPKTGKSTLETVLTNLHAGGK
                     FGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQ
                     DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHY
                     TGGLVEYIKYLNKSRTGIHDDIVYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTH
                     EGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLTAVVSVKLPEPQFEG
                     QTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELT
                     RRKSVLESTSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKI
                     LNVEKSRLDRILSSDEIKNMITAYGCGIGEDFDIDKARYHKIIIMTDADVDGAHIRTL
                     LLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGRNGVELQ
                     RYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEEN
                     ARFVRNLDI"
     gene            complement(6558..7673)
                     /gene="recF"
                     /locus_tag="KRO40_000338"
     CDS             complement(6558..7673)
                     /gene="recF"
                     /locus_tag="KRO40_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HBH2091181.1"
                     /translation="MKLKSLQLVNFRNYKKLHLEFNGKVNLLVGKNGQGKTNIVESIY
                     MLSFGKSFRTNKDKEMVRFNSENLYIGGSFSKYNKYSLIELIIGKDKKGIRINKVPLQ
                     KIQELLGNLNVVIFSPEDLRLVKEGPKERRAFIDKEISQIIPKYYKYLTNYNKTLSQR
                     SRVLKNIHVDEALLDVYDDTLAKYGSYIYILRRDFIKKIANISENMHMNLTNGVERLS
                     IRYKNQINITDEDTIDTVYNKFLAKLSSNRPNDIESKTTRYGIHKDDLNIFINDLDAR
                     LFGSQGQQRTASISLKLSEIELIKNEVEEYPVLILDDVFSELDEARQKLLVNNLSNVQ
                     MFITSAEVSHKKIFDEKNVTIFNIENGDVISIENGGN"
     gene            complement(7691..7897)
                     /gene="yaaA"
                     /locus_tag="KRO40_000339"
     CDS             complement(7691..7897)
                     /gene="yaaA"
                     /locus_tag="KRO40_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HBH2091182.1"
                     /translation="MTEITIESEYIKLDQFLKLAEIASTGGHAKFLIQEGLVTVNDEI
                     ELRRGKKIKSGDIVEIEGTKIKVL"
     gene            complement(8034..9140)
                     /locus_tag="KRO40_000340"
     CDS             complement(8034..9140)
                     /locus_tag="KRO40_000340"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HBH2091183.1"
                     /translation="MKIICNQKILANRIGIAQKAINGKTTIELLKGILISTEEGQLKL
                     TGYDAEIGIETYVQAEIIEKGDVVVDARLFGDIIRKLPDSFVEIETDSENNIYINCVN
                     SRFKIKGYAAKEFPKLPELNEEDLYSIPQEILKNMIKQTVFAISQDQTKPVLMGELLE
                     IVDRNLNLVAIDGYRLAVKSCSVDSLTENIKVIIPGKTLIDVNSLLSGEDNVKVGFNE
                     KNAIFIINDTKIITRLLEGDFIDYKKLLPREHNSRVKLNTKELLNSIERASLLSQSEK
                     NNLIKLSIRDKVMAITSNTEKGNVYEEVEIDLDGDYLDIAFNSRYFIEGLKNIDNEEI
                     FIEFTTNVNPCIIKPTDDVNYIYLLLPVRISSNI"
     gene            complement(9382..10704)
                     /gene="dnaA"
                     /locus_tag="KRO40_000341"
     CDS             complement(9382..10704)
                     /gene="dnaA"
                     /locus_tag="KRO40_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HBH2091184.1"
                     /translation="MMDIVSLWDKTLQLIKGDLTSVSFNTFFKNIVPLKIHLNDLILL
                     APSDFNKDILENRYLHLIEDAISQLSLKKYNIKFVLSEKEVADLNSDSTDLNYRVLYP
                     NLNPKYTFDTFVIGNSNRFAHAACVAVAESPAKAYNPLFLYGGVGLGKTHLMHAIGHH
                     IVSQKKDSKVVYVSSEKFTNELINSIKDDKNEEFRNKYRNVDVLLIDDIQFIAGKERT
                     QEEFFHTFNTLHEANKQIIISSDRPPKDIPTLEDRLRSRFEMGLITDIQAPDFETRIA
                     ILRKKAQLERIDVPNEVMSYIAKNIKSNIRELEGALTRVVAYSSLSNRVISFDLATEA
                     LKDIITTSKNEEINVLRIKEKVSSVFNLKMEDFNSKKRTRSIAYPRQIAMYLTRELTD
                     LSLPKIGEEFGGRDHTTVIHAHDKVSKDIEESEEIKTKIDKIISDLKG"
     gene            11360..11497
                     /gene="rpmH"
                     /locus_tag="KRO40_000342"
     CDS             11360..11497
                     /gene="rpmH"
                     /locus_tag="KRO40_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HBH2091185.1"
                     /translation="MSKRTYQPKKRQRSKEHGFRKRMKTSNGRNVLKRRRAKGRNRLT
                     H"
     gene            11575..11919
                     /gene="rnpA"
                     /locus_tag="KRO40_000343"
     CDS             11575..11919
                     /gene="rnpA"
                     /locus_tag="KRO40_000343"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HBH2091186.1"
                     /translation="MDFNRTKGLKKDSDFRKVYKHGKSFANKYLVIYILKNKSDYSRV
                     GISVSKKVGKAITRNRVRRLIKEAYRLNIDEKIKPGYDIVFIARVSSKDATFKDIDKS
                     IKNLVKRTDISI"
     gene            11951..12202
                     /gene="yidD"
                     /locus_tag="KRO40_000344"
     CDS             11951..12202
                     /gene="yidD"
                     /locus_tag="KRO40_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HBH2091187.1"
                     /translation="MNKIIYILKEISKYLSNLCIYLVRFYQKYISPLKGPTCRFYPTC
                     SQYSIEAFKKYGFVKGMYLTIRRILKCHPFHPGGYDPLK"
     gene            12234..12941
                     /locus_tag="KRO40_000345"
     CDS             12234..12941
                     /locus_tag="KRO40_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBH2091188.1"
                     /translation="MNIIGNFLGLILKVIFEFVNHYGISIILFTILVKIILLPLTIKQ
                     TKSTKAMQDIQPRIKEIQEKYKNKPEKQNEEIVKLYGEAKINPLSGCLPLLIQFPILI
                     GLFSVLREPVAHGVFANKAAFLAADNGFLWIKSLTSPDYVLAVFSGASAYVMQKVMTP
                     KDQLQGSMKVMTYVMAGMSFYWGFIFPAGLTLYWTVSNLFSIAQYYLIMNPLKAKLAA
                     NSKEEKVNEKKPKINKK"
     gene            12910..13539
                     /locus_tag="KRO40_000346"
     CDS             12910..13539
                     /locus_tag="KRO40_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HBH2091189.1"
                     /translation="MRKSLKLIKSKSKEEAISKAIAELNLKAEDIEVEILENPSKGFL
                     GFIGAKDGTYEIFVIEREVDVAKNFIEVMLKNANVDAKVNVSQKDNLIMVDIEGKEAA
                     SLIGRRGETLDSIQFLTGLALNKINKDSHTRVLVDIENYRSKREESLIRYANKVAREV
                     AKTRKTKKLDYMNPYERRIIHSALQNDKYVITYSEGTDPYRRLVIECKR"
     gene            13651..15030
                     /gene="mnmE"
                     /locus_tag="KRO40_000347"
     CDS             13651..15030
                     /gene="mnmE"
                     /locus_tag="KRO40_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HBH2091190.1"
                     /translation="MFIDDTIAAIATAPGEGGIGILRISGEKALKVAEEIFKSMSGKS
                     IEEYNKRTLIYGNIVDNENIIDEVLLAYMKGPNSYTGEDVIEINCHGGFISVKKILEL
                     ILSKDVRLAEAGEFTKRAFLNGRIDLSQAEAVIDVIKAKTDIAHEVAQNQLEGSLSKK
                     IRELRDKVTEILAHVEVAIDYPEEDIEHITYQTLKEKTDELKKDIKKLYDTAESGKIL
                     REGLKTVIVGKPNVGKSSLLNSILGENRAIVTDIPGTTRDVIEEFVNIKGIPLKIVDT
                     AGIRDTDDIVEKIGVEKSKESFTSADLIVMVLDASRKLSEEDIEILEKLKDKQTIVLL
                     NKNDLKQEIEEEKILKYVENNSIIKISALQQEGIEELQDKIESMVYKGSIKNNSSLVV
                     TNSRHKDALSKAYKSATDALIALEQSMPFDFVEVDLKNIWDYLGYINGDTVTEDLLDN
                     IFHNFCIGK"
     gene            15128..17020
                     /gene="mnmG"
                     /locus_tag="KRO40_000348"
     CDS             15128..17020
                     /gene="mnmG"
                     /locus_tag="KRO40_000348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012065747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HBH2091191.1"
                     /translation="MKFEAGKYDVIVVGAGHAGCEAALATARMGYKTLIITMSLDSIA
                     LMPCNPSIGGTGKGQLVKEIDALGGQMGLNIDKTYIQSRMLNTAKGPAVHSLRAQADK
                     FKYHEEMKKTLEDEPNLDIAMDEVVEILHEGNVVIGVGTKLGCSFKSKAVILATGVYL
                     NSKIYMGEVAFYEGPNALGYAKYLTDSLVELGLRMRRFKTGTPARVHRDSIDFSVMSL
                     QEGDEKVTPFSFMNENIEKKQEPCYLTRTTEETQKVILDNLKRSAMYSGVIESTGPRY
                     CPSIEDKVVRFSDKTSHQLFIEPEGLNTKEMYIQGISTSLPFEVQLDMYKTIKGLENC
                     KIMRPAYAIEYDCVDPTQLKISLEIKGVENLFSAGQFNGTSGYEEAAAQGLMAGINAV
                     RKIEGKEPFVLDRSEAYIGVLLDDLVTKGTNEPYRMMTSRAEYRLYLRQDNADMRLTQ
                     KGYDIGLVKKDRYERFLNKKAAVEKEFERLKNERVTPKEVNSLLEEKGATPIKVGISL
                     YEFLKRPEVTYELLEELGKGAGEDVSREVKEQCVIITKYEGYIEKQLKQIDQFKKLEN
                     KKLDEKINYSSIEGLRLEARQKLDDIKPISIGQASRISGVSPADISVLLIYLEQIRRT
                     RGGKGE"
     gene            17013..17732
                     /gene="rsmG"
                     /locus_tag="KRO40_000349"
     CDS             17013..17732
                     /gene="rsmG"
                     /locus_tag="KRO40_000349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HBH2091192.1"
                     /translation="MNNIELLKNGIEGFNIDTNDSMLEKFKIYREILVDWNKKMNLTG
                     IEDEKEVYIKHFLDSISAVKNGYIKNGMSIIDVGTGAGFPGIPLKICLDSLELTLLDS
                     LNKRINFLEEVSRVLELDNITFIHGRAEDFGKNEDYREKYDVATARAVAGLPILMEFC
                     VPFVKVGGYFICLKGPNANLELEESQKAIDVLGLEYIEKIDVELPEVDLNHNILVFKK
                     VMETPVKYPRKAGKPAKNPIK"
     gene            17895..18680
                     /gene="noc"
                     /locus_tag="KRO40_000350"
     CDS             17895..18680
                     /gene="noc"
                     /locus_tag="KRO40_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid occlusion protein"
                     /protein_id="HBH2091193.1"
                     /translation="MEDKRVMEIPIEDVVPNPYQPRKIFSQVSLEELSNSIKVYGIIQ
                     PITVRAKDGKYELIAGERRLRAAKLAELKTIPAIINNMNDESSAVLALLENLQREDLN
                     FIEEAIGYENLIKEHAFTQQQLAEKLGKNQSTVANKLRILKLPNDIKMKLIENNLTER
                     HARAFLKLPSEDLMQSVLDKVIKNELTVKKTEKLIQDVLEETKVQEEPDKKQNIKGAM
                     SIRIYINTIKQAFDAISNTGIDAKYNEIDKGDYMEVVVKIPKK"
     gene            18815..19588
                     /locus_tag="KRO40_000351"
     CDS             18815..19588
                     /locus_tag="KRO40_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="HBH2091194.1"
                     /translation="MGKVIAVFNQKGGVGKTTTNVNLSASLGTLGKKILVLDLDPQGN
                     TTSGYGINKNEVENTIYEIMLDGLHIKEAIISTEFENVDVVPSATELSGAEIELTSKT
                     NREYILKNSIKAVIDEYDYIFLDCPPSLGMLTINCLTAVDSVLIPIQCEYYALEGVSQ
                     LMETIKLVKSRLNADIEIQGVVLSMFDGRANLSIQVVEEVKKYFKGSVYTTLIPRNVR
                     LAEAPSHGKPVIYYDKRCRGSVAYLELAEEFIDLEEEEW"
     gene            19590..20453
                     /locus_tag="KRO40_000352"
     CDS             19590..20453
                     /locus_tag="KRO40_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HBH2091195.1"
                     /translation="MENKSKRSNRLGRGLSALIPEIKGETSEKEIVNIDIDKIYPNEV
                     QPRKQFDEEKIKVLSDSIKNYGVLQPIVVKMDENNKYMIIAGERRFRASKLANKNQIP
                     AIIKDIDMKDIMEIALIENLQREDLNSIEEALAYKSLIEHYNVTQEEISEAVGKSRPH
                     ITNTLRLLNLGQDVIEMIDSGRITAGHGKALLRIADKDLQLQIAKKIEEEELSVREVE
                     NIAKKISENKQEEPKKSKPKDVFILDVEDKLRNIFGTKVNISKGKKKGKIEIEYYNDD
                     DLNSIVSMLLE"
     gene            20486..21628
                     /locus_tag="KRO40_000353"
     CDS             20486..21628
                     /locus_tag="KRO40_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH2091196.1"
                     /translation="MIYLDNAATTYPKPERVYNAVLDCMKNYCANPGRAGHKLAMRAA
                     REIYDTRENIAKLFNVSNPMNIVFTSNATDSLNLAIKGVLQEGDHVITTSMEHNSVIR
                     PIKALEKRGIENTVVKCDYEGFLDYEDLEKSIKSNTKLIVTTHASNVCGTLIDIKKVG
                     EIAKKHNILFLVDASQTAGVYDIDVNECNIDMLAMPGHKCLFGPQGTGILYVREGLNL
                     NILKEGGTGSKSEEIVQPELFPDKYESGTHNTPGIAGLNQGILFIFERGINNIRQHEE
                     ELCQYMIDKLEEVPDIKIYGPKDSKKRASVIALNIGDMDSGEVTFLLDSDYNIATRSG
                     IHCSPLAHTTLGTLKQGAVRFSIGYFNTKDEIDKAVEALKKISKNK"
     gene            complement(21761..22336)
                     /locus_tag="KRO40_000354"
     CDS             complement(21761..22336)
                     /locus_tag="KRO40_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerMN domain-containing protein"
                     /protein_id="HBH2091197.1"
                     /translation="MKNKKIMLVLSILSISIFAVGCTNAQNGSDSSKKETKSNTNVEQ
                     PKEENNTEKEVPNNKAKLTPKEETKAQSATIYSFDVDKTDLIENKVDLNKIDENTLFE
                     ELQKLKVVPESAKLNSFTTKDIDGVKTGILDVSSDFTKSNLGSDAETLMLDSVARTYI
                     KNMNVEQIKITVDGSNYESGHIVLEEGDYLK"
     gene            22596..23888
                     /locus_tag="KRO40_000355"
     CDS             22596..23888
                     /locus_tag="KRO40_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH2091198.1"
                     /translation="MEILSLGEKIKKLRKEKNMTLKELAGDRITAAQISHIERDKSHT
                     SYELLEYLGDKLDVSVEYLLETKEMQSKKITDNLILQSEIYIKENELNKAEDQIKEVL
                     DICKRYDLMENYGRCNFLMANINLKKSNYNDAIENFEKALYFFIKNSDSENILKCYLN
                     IGKIYMQEDFYKGAISHFNFAEEILSENKFEDVNIHKELYSKMAYCYIKLDNPNMSLK
                     YIEKINEIDNRNDRKEDVDILVLKANNMLEIGKYEESRDYFKKALKILESEDNKTGLA
                     NVYLTICDVYRKIGETDRVLEYSQKVYDIKKNDEDEYMMSGLFKIIEAYIDKEDYDLA
                     RKYCKIALASSIKNKNKFNEYKALRFYANMYKNQNEVTLAIEYLIKCIKIVSDLGNNR
                     ILANLYIDLGQLYSNISKEKELEYYQKGVFMYKNLEIM"
     gene            23993..24595
                     /gene="yedF"
                     /locus_tag="KRO40_000356"
     CDS             23993..24595
                     /gene="yedF"
                     /locus_tag="KRO40_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase-like selenium metabolism
                     protein YedF"
                     /protein_id="HBH2091199.1"
                     /translation="MSIKIDARGLACPKPVINTKRELDNLEEGVVVTIVDNETAKENI
                     LKLAKSLSCEANIVDEKENFISIEIRKGKNILDKQNVVDNKESELDNTCIFISSDKMG
                     LGNDELGKVLIKGFIYTLTESKPYPKYVLLVNGGVKLSAENEETIENLKILENMGVEV
                     LSCGTCLDYYNLKDKLQVGTVTNMYTIVETLKNASNTISI"
     gene            24668..24931
                     /locus_tag="KRO40_000357"
     CDS             24668..24931
                     /locus_tag="KRO40_000357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3343 domain-containing protein"
                     /protein_id="HBH2091200.1"
                     /translation="MNQMYIVSFNSTHHAIRSEKLFGENSLKVMALPTPREITASCGI
                     SIKFSFEDMEKIKTILVENNVDIKGIYCISKLENGSKEVEKLD"
     gene            24946..25131
                     /locus_tag="KRO40_000358"
     CDS             24946..25131
                     /locus_tag="KRO40_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 domain-containing protein"
                     /protein_id="HBH2091201.1"
                     /translation="MPMDLKIGDIVELKKQHACGCKEFEIIRTGMDIKIKCTKCSRLI
                     MLDRETLEKRVKKLIKK"
     gene            25234..26430
                     /locus_tag="KRO40_000359"
     CDS             25234..26430
                     /locus_tag="KRO40_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2091202.1"
                     /translation="MAVKYAKRMQGLQGSEIRELLKLTQQPQIISFAGGMPAPELFPV
                     EEMKKVSVAVLEENGRSAMQYTTTEGYEPLREKIAARMNDKNKTNVNKDDILVTSGSQ
                     QGLDFAGKVFIDEGDVILCESPSYIGAINAFKSYQPKFIDVPTDSDGMIMEELEKILE
                     TTDRIKMIYVIPDFQNPTGRTWPLERRKKFMEIVNKFEIPVIEDNPYGDLRFEGETLP
                     SLKSMDTKGLVIFLGTFSKIFCPGYRLGWTCASPEILSKFNFAKQGADLQASTISQME
                     VSKFMDMYDLDAHVDKIKAVYVKRRDVMLKTMEEEFPEGLVFTHPEGGLFTWVELPSN
                     LNAKELMPKCLDKNVAYVAGGGFFPNGGRENTFRLNYSNMPEEKIIEGIKNIAAVLKE
                     AMGVEA"
     gene            26644..26922
                     /locus_tag="KRO40_000360"
     CDS             26644..26922
                     /locus_tag="KRO40_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HBH2091203.1"
                     /translation="MRNYELVYVVKPNSDEEVREAILNKVKEVVATDGEIVKVDTWGT
                     KKLAYPIAKFTEGFYVLVNFKSAVDVPKEIDRNLKINENVIRHMIVVA"
     gene            26959..27393
                     /gene="ssb"
                     /locus_tag="KRO40_000361"
     CDS             26959..27393
                     /gene="ssb"
                     /locus_tag="KRO40_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH2091204.1"
                     /translation="MNQVVLVGRLTRDPELRYIPGTGTPVASFTIAIDRDYVKKDGSK
                     ETDFIPVEVMGKSAEFCANYITKGRLVALQGSIRVDNYQTQSGEKRTFTKVSTRSVQA
                     LDSKNKSENSYRESAPAFEPSFEPQGLDPQGFQAIDDDDIPF"
     gene            27412..27639
                     /locus_tag="KRO40_000362"
     CDS             27412..27639
                     /locus_tag="KRO40_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HBH2091205.1"
                     /translation="MMNKKRRKKKRVCQFCADKNAKIDYKSTQRLQKYITERGKILPR
                     RISGTCAKHQRELTVAIKRARNIALLPYTLD"
     gene            27782..28102
                     /locus_tag="KRO40_000363"
     CDS             27782..28102
                     /locus_tag="KRO40_000363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBH2091206.1"
                     /translation="MKIDKGSEITRNIKIIEWMKTEILMSVSDLFNLLFKGVKPLDEA
                     IQDTLANIIMITYLLAKRLGISFRDVDYKVKEKIKIGIDEDHSVERWYGDLSNLKKHM
                     DNRE"
     gene            28110..29066
                     /locus_tag="KRO40_000364"
     CDS             28110..29066
                     /locus_tag="KRO40_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YybS family protein"
                     /protein_id="HBH2091207.1"
                     /translation="MNNKIRLSKAMSIIVLAIIIALVIAYIPMLGIFSMLAAVPYVII
                     GAITDRKYSLISILVTFCVLILFADISYALNICIMYSLPGIVIGKMLKRSFEQEDSNK
                     FEPIYGGTIIFVLSMLVYFFVLKTFLNVNLLDEVSKMISEIVNIQKNSFSATELKVFD
                     KMKPDEIVSYFTNMLPMMLFLQGLLSAFVTYYLSVFFIKRITKMNIRFPKFADFYLPG
                     NAILTTFLLYLLVLFIQIIGSKLYTELIMTNLQLVFNLMFVIQGIAVCIYFLKKWIRQ
                     GPNKIMFFSGIILCLFGFMGISFVGMVDSIIDFRKVRSYKST"
     gene            29077..31071
                     /locus_tag="KRO40_000365"
     CDS             29077..31071
                     /locus_tag="KRO40_000365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HBH2091208.1"
                     /translation="MSNKQTFKLNMPEINLYIIVIGISSIILLYYNLYVGCLFFCIFV
                     YMVFHNWRTTNIRRHEWTEYIQNLSLDIDETTKKAIINLPIPLCILEFDGNISWYNGK
                     FYDMIGQKDLLDKNIEDIVKNLNLRKVLNENKEMYTEINYKEKEYTIIYNVIKNDQEK
                     NPKYLMILYWIDKTEYLKVKQNYDDEKNAMMLIQVDGYDEVLKSAAEDKRALINVEVE
                     KILSALELNSNGALRRTSKDKFFLVMHKKELKKLEAEKFSILDTIRHIDYGNNLPVTI
                     SIGIGIDGDTLNENLKLATGALDLALGRGGDQAVVKTKDKFVFYGGKSKAVEKKTKVK
                     SRLIGHALREVIQQSDQVYIMGHKYPDMDAMGAAVGVYDICKSCNKTANIVLQSVNES
                     IEIFINKINENNYYKKLFIGKEEAIDNCTKNTLVVVVDTHRPNYTECEELLKLSEKVV
                     VIDHHRRGVEFINDAVLLFHEIYVSSTCEMVTELVQYMDEDVTINKLTAEGLLAGISL
                     DTKNFAFKTGVRTFEAASYLRKVGADTIEVKKFFNSDVKDFIIKAEIIQSTKIINNRI
                     CLAYSSTEIDSINVIIAQTADELLNIKEVEASFVLGEKDDTIFISARSLGQINVHVLM
                     EKLGGGGHIDIAGAQLKNVSLKEAYKMVNKIIEEYLEEEE"
     gene            31072..31521
                     /locus_tag="KRO40_000366"
     CDS             31072..31521
                     /locus_tag="KRO40_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HBH2091209.1"
                     /translation="MKVILLKDVKGTGKKGEMKEVSDGYARNFLFPKKMAVQADSVAI
                     KELNEKNKSKEIKAQKEYEEAVLLGKQMEEINIEIYSKAGEGGRLFGSITSKEIAEQL
                     KKQKDIDVDKRKILLDEPIRSLGSTFVEIKIHQKVTTKIRVDVKEKQ"
     gene            31540..32868
                     /gene="dnaB"
                     /locus_tag="KRO40_000367"
     CDS             31540..32868
                     /gene="dnaB"
                     /locus_tag="KRO40_000367"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HBH2091210.1"
                     /translation="MEDMTRIPPHSVESEQSILGSILLDKDAIITVTETIKPDDFYKE
                     AHKIIYECMITLSNKGEPIDLITLTEELRKQGHLNDIGGISYITSLSTIVPTTSNVKY
                     YADIVKEKSVLRKLIKASNEIINLGYSGATKIEDVLEQAEKSIFDISQEKTSDDFKSI
                     NLVLMDAYDMIEKLYTNKSDVTGITTGFKDLNKKINGLQRTDLILIAARPAMGKTAFS
                     LNLVQNAALKGDASVAVFSLEMSKEQLVQRMLSSQSSVELKKIKTGTLNDNDWPRIID
                     AMAVLSDAKIHIDDTPGIKISELRSKCRKLKIEKGLDLVLIDYLQLMEGEGNNESRQQ
                     EISKISRSLKILAKELNCPVVALSQLSRAPEQRADHRPMLSDLRESGAIEQDADIVMF
                     LYRDEYYHADSESKNIGEVIIAKNRHGETGSVELVWLGEVQRFGDKLRDL"
     gene            33073..33381
                     /locus_tag="KRO40_000368"
     CDS             33073..33381
                     /locus_tag="KRO40_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091211.1"
                     /translation="MEKISLKYIYPNIIKVLDEINLFRVIDNNLRESIVVYANNVDNQ
                     YHINMTNTNFGNIINICKLEKLLDVDKFMEKVIKYEKEIIEKEEFSKIEEYMLNIGEY
                     "
     gene            33463..34752
                     /locus_tag="KRO40_000369"
     CDS             33463..34752
                     /locus_tag="KRO40_000369"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HBH2091212.1"
                     /translation="MKTVAIVGSQWGDEGKGKVIDYLATQADVVVRGQGGNNAGHTLV
                     VEGKKYALHLIPSGVLNPNTVNIIGNGIVFDPKGFLEELEMFKTDNISTENIKISDRA
                     HVIFPYHKELDALSEEARGDLKIGTTKKGIGPCYMDKTERSGIRICDLMDKDKFAIKL
                     KAQIDAKNEIVKNIYGKEELFDFETIYNEYLGYAEQIRKYVADTSVIVYDAVRAGKKV
                     LFEGAQGTLLDLDLGTYPFVTSSHPTSGGFAIGAGIGPNMIKDVVGIVKAYTTRVGEG
                     PFVTEQINETGDKIREQGHEFGVTTGRPRRCGWFDAVIVKYAARVNGLTSISFMLLDV
                     LTGFDKIKVCTSYKMGDKIITDFPASLDDLAKCEPVYEELDGWNEDITQIDNFDDLPE
                     NAKKYVAKIEELVGVSVDMVSVGPNRAQTIIRRNIFA"
     gene            35078..35153
                     /locus_tag="KRO40_000370"
     tRNA            35078..35153
                     /locus_tag="KRO40_000370"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35111..35113,aa:Lys,seq:ttt)
     gene            35160..35234
                     /locus_tag="KRO40_000371"
     tRNA            35160..35234
                     /locus_tag="KRO40_000371"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35193..35195,aa:Glu,seq:ttc)
     gene            35239..35314
                     /locus_tag="KRO40_000372"
     tRNA            35239..35314
                     /locus_tag="KRO40_000372"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35272..35274,aa:Val,seq:tac)
     gene            35348..35422
                     /locus_tag="KRO40_000373"
     tRNA            35348..35422
                     /locus_tag="KRO40_000373"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35380..35382,aa:Thr,seq:tgt)
     gene            complement(35805..36797)
                     /locus_tag="KRO40_000374"
     CDS             complement(35805..36797)
                     /locus_tag="KRO40_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2091213.1"
                     /translation="MNEDKIRKILAKYAKRRDDNELLLEHRKNEVYNRIPEIKSIDDE
                     ISKIGLSLAKIVLLNPKSKDEIVKKTKENIESLKVKKERLLAESNIPLDYLEIKFQCI
                     SCKDKGFLPNGEKCSCLKQEIVNEAYKMSNLDRILSQENFSNFNLNIFSPKKGSDGEI
                     SPRENMLNNLSICENFVHDFKKDNSENLLFYGSTGLGKTYMCNCIAKELLDKGNVVIY
                     QTSFRILDILEDYKFRRDTNNQISEDNYKNLFDCDLLIIDDLGTELNNSFTSGEIFNI
                     VNTRLVAGKKIIISTNLTPSQIGNTYTQRTLSRILDKFRILEFTGDDLRWERFK"
     gene            complement(36806..37864)
                     /locus_tag="KRO40_000375"
     CDS             complement(36806..37864)
                     /locus_tag="KRO40_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBH2091214.1"
                     /translation="MFFKESNEIDLGEITIPNIFIDIFMPMADGLYVKVYLLGYRQAC
                     DITSNPKFDNNSIAKNLNIPLSDVLSAWKFWEEKKIIKIHDNGEYDNFNYSIEFLDLK
                     NFYIENILSNNSSIKSNTDKVVSTSENPSIRKMFNSINKIVGRYLDPSEKMSIMDIMN
                     KYNMSPDMILCAYEYVKDKTGTSKPVKYIEGIIRNWYDSNLYTPKDVEESFLVRSERY
                     ILYKTIFNELGFSRQPSKSEKELMDTWFDKFNMDIDLIINACSKSKNISNPSISYING
                     IIKNWNEKNIKNLNDLKQKEEERIVKENINKKQINTTQNNNTYKKTKFHNFNETFTQY
                     TSDELDEIIKKSQKEKFK"
     gene            37989..39452
                     /locus_tag="KRO40_000376"
     CDS             37989..39452
                     /locus_tag="KRO40_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HBH2091215.1"
                     /translation="MVIKFNQKVRRTLSVAILFMVLIIGCFIEKDDSLETYKEKTNSK
                     INQYNMDVIFDDETKRLMCNQNVDYINNTKSNLDKIYFHIYPNAFSKKDFAPFEKSEM
                     TRAYPNGFNEGYIDIKNILNNNSKMEYKIKGDKNDILEIELGKELKPNERMSLDIKYN
                     VKIPNSIGRFGYGENTINVTNWFPIACVNDERGWNLKSYETIGDPFYSETSDFHVKLL
                     IPNKYKIAHTGKLIDDKHDNKKMLYEIEAENVRDFAFILSSKFNVNKVDSKGVAINTY
                     NLNKKLSKKATEVAKDSINIFSELFGKYPYKEFSVVASDFFIGGMEYPMLVMIDQSLY
                     NEKNEFLLEYVIAHETAHQWWYSAVGNDEISEPWLDEALTEYSTIVYFEQKYGKDMAN
                     KLIKTMEIQTKSYLSENIFKPANEYKNSTEYSLNVYTKGAIAFNEIRKEVGDKVFFET
                     LNEYYNKYKHKNANGRAFVELWNSKGVDINKIISECK"
     gene            39554..40351
                     /locus_tag="KRO40_000377"
     CDS             39554..40351
                     /locus_tag="KRO40_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2091216.1"
                     /translation="MLKYCSVGSGSSGNCHYIGYKNTNILVDAGLSGKRITTGLKDIG
                     VDADKLKGIFITHEHVDHIKGAGILSRKFDIPVFANIKTWCSMKDKLGDIKDKNMKVF
                     ENDKTYSLGDIIVRPFSIEHDASDPVGYNFYTESDEKMSIATDIGCITQNIKKHLYKS
                     KLVVLESNYDPNMLMMGSYTYALKKRVMSSTGHLSNEDAANFCVELINEGTESILLAH
                     LSKENNFPELAYETSKGVLASNDIVVGQDVKLDVLSRNDVSNVYEMK"
     gene            40364..42466
                     /locus_tag="KRO40_000378"
     CDS             40364..42466
                     /locus_tag="KRO40_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC/EAL
                     domain-containing protein"
                     /protein_id="HBH2091217.1"
                     /translation="MLKRNFENVEDNKILYSIKQGMILAIPAIMTGSTALVILNLPIK
                     AYQEYLSGLFNGEVTNILNFINDSTLGIISLIILLTISYSYGKIYGSKYTVLVPIVAM
                     CSFLVFSHGNELNSYIEIFKTKWLFTSIIVSMTSSVLFVKLTESFVTSVKFHTEGADA
                     DFNMVVSAIVPFIIVVFLFSIFRVIMISLIGSSNFQDIFYNLFSNVFNKMGTNLMSAL
                     LFIFLMHFMWFFGIHGSNVLDTVAKNLFENSMAININLVNNNQLPTEIFTKTFFDTMV
                     LLGGCGSLLCLVIAIFLSEKRINVRKLAKIASIPALFNINEMLVFGIPIVFNYIMFVP
                     FVITPIILTITSYVAMSTGIVPCTVSAVEWTSPIFLSGYMSTGSIRGSLLQVFNLCVG
                     VMIYIPFIKMSQNRYTYMFKNNIENLTNLLKRYELTGEQPNLLNHNGKIGSISKMLAS
                     DLKFAMKRGEIELFYQPQVNYNGNVVGAEGLLRWKHSIGGFIYPPLVIILAKEEGFLD
                     ELGEYIINKACIDLKKSEKLLRNPVKFSVNISPDQLDDPKLPEQIKNIISSNDINPNM
                     LGIEITEQIALSGSQIIIERINAIHNLGIKLIMDDFGMGHSSLIYLQNNNFDIVKLDG
                     SLVKEILTNKRSSEIIMTIVNLSKNLDFDIVVEYVENIDQRDKLYGLGCEIYQGYYYS
                     KAIPFEEFVEYANQEREI"
     gene            42534..43013
                     /gene="rlmH"
                     /locus_tag="KRO40_000379"
     CDS             42534..43013
                     /gene="rlmH"
                     /locus_tag="KRO40_000379"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HBH2091218.1"
                     /translation="MNISIVVVGKIKEKYLKLGIDEFKKRLSKYCKLEIIELDDEKAP
                     ENLSVKEMEIIKDKEGKKILGKIKHNSYVIALAIDGKGLSSEELAKTMSDLAVRGNSS
                     LCFIIGGSLGLSDEVLGRADYRLSFSRMTFPHQMMRLILLEQIYRAYRINNGEPYHK"
     gene            43080..44771
                     /locus_tag="KRO40_000380"
     CDS             43080..44771
                     /locus_tag="KRO40_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091219.1"
                     /translation="MDRLDIFIENYDFKEYLEKLPRELIEENYKDFVIEFWKNPSVDI
                     IKLKSKYSIKNVVSISSILMQNPIQEYYEFLEDIWKNNIKIDELINKYLITATRMDQI
                     KFPLIYIDEDSFCPYCLGNKFNIINNIKQQDIKVECEKCGEAISYFIHKEEVDNIIEE
                     EKRKKELFIRTLENVYNKINKIKCHRCQSDLYVCINDKIMEYNIRCDRCNSQYESVEI
                     AQEQYRLWQQRAAMMANIKNKENELLLKTLSIKDEKDIKFKLEDIITESESIDVISDL
                     VDMQDRGENIFKQLFNNYVRLGRLDRRLLVTVCKDCKQNENTYTWERGKEHLINMRGI
                     TYSEAVVYELMEKTKLLPIRAIIRRLMEKKLLYCDERSNNLQVHPVLIENLAKLESIN
                     KSQNINNQVAYLIFNKQKYICYHCGESGRPLKIGYLTIDKNINDLSSLVGICDSCYED
                     ITEDEIIIDNIFCVVDERNNELGEAWKFLIQYDSSFRNNTIAEVEHARLYDMYDEDNL
                     IRAYANTLYKQTKDGFANEKVFFAYARAILKNSKGQVSVLQIAKEKFKLEKWLNG"
     gene            45003..46475
                     /locus_tag="KRO40_000381"
     CDS             45003..46475
                     /locus_tag="KRO40_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091220.1"
                     /translation="MSHSKLSDHKLKKGKFIAPFNEFMTPLNSNESWCLGRLPEYIWI
                     GLLINKYGRKKGMEIIYKIIVKLHSIESDIVTPRLSEILSMEDVKQDEFFSYILTIVE
                     KEALSPLTLIFTYSNYPIFVKYFAEPSIKIEDRVTYLDETLRKAMHHQSEFATDIRFI
                     VLYYFCMSGKLVLQKEQINNLLEYPNLEHTDEKMRMLRPFIRAAELMVLNMEKKSDWY
                     LDIFWGRISVMTECKLYATKFEDETANTDLYMEQLHEIFVYLSDLLCKVNPLDEKMLV
                     LLGIAIYSYKRLREVVEHKLFNSISGRGSVRVLIENYIMMKYLVKIEAQHENIWSEYQ
                     FYGIGQYKLIVARYREQEQDLKNSHVDYKYIEALVNEFVIEETIDMDTKYFDKQNIRS
                     KAEIVGEKELYGLYYDYDSAYEHGLWGSIRESSMLKCDNPAHHYHCIPDVDNNQNLKS
                     VWHDCVNIMEKTLLFLDTVYGIPQHLLLEVIKNGKEFFTK"
     gene            46450..47514
                     /locus_tag="KRO40_000382"
     CDS             46450..47514
                     /locus_tag="KRO40_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091221.1"
                     /translation="MEKNFLLNKINSIQKEYLELLVKLKDNIDTIDYIYIIDEINIFW
                     YSYRDVIKLYLGNITQKDNAYIFTGATYLDVDDLEHYPFVMMGDIHIVDDSLCKYSKT
                     VLVLSNQEFAKVLKDQIISCIDDNIKILSNYSFAMLILPMNLLYGNDMKIIHEYSNNI
                     FLNFFSRKDLNLDTYFEEFNSIEDIALALNPGIESYIVFDEGEDLTKNLEERFKSFID
                     KGKVPLPAHKSDAFKFWLIIYGFITQALDIILSCKGFNLTPYLRYRVTLQYVLLLGDN
                     VFDIEDLSNMLLKCKVAHVLYAIFDKSEIKNISFVQFYKKLSEYKFSYKVENDIKENI
                     NINQIAEILNKNITLFLNYI"
     gene            47654..48826
                     /locus_tag="KRO40_000383"
     CDS             47654..48826
                     /locus_tag="KRO40_000383"
                     /inference="COORDINATES: protein motif:HMM:NF013752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2091222.1"
                     /translation="MLKQNTIQIDYTTYGNNYQFKLPLNIDYMIPKDAIFVDGTKIES
                     SANRYTFVWKKTINKNMVRVMNDISNFILKCGIDFGIKIIYRNKIKIYHLKKLLKKLK
                     KISKESNITFVHGKGKKKSIVQKSIAKLNNYIDRLKKYTKDLHIMGELNSYSKTDNDA
                     TFMRMKKDHMKNGQLKPAYNIQFGVDSEYIVWVSSEHKPTDTTTSIPFLKSIEEHTKF
                     KYPKIVADSGYESEENYTFLECNNQLSFIKPANYEISKTRKYKNDIGRIDNMDYDEKK
                     DYYICKNGKKLFANKIINRKSKTGYKSKITCYTCKECCDCQYKNGCIKGNNSKIPLEN
                     RTKNLQVSKLFHEKRKENLKRIISQEGCQLRMNRIIQAEGTFAQVKQNMKFRRFLS"
     gene            49268..49579
                     /locus_tag="KRO40_000384"
     CDS             49268..49579
                     /locus_tag="KRO40_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091223.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMESAAKENGIESQIWAIPESTIQN
                     EIEKCDVLLLGPQVRYVLPKAQEIARPYNIPVEVINMMHYGTVNGEAVLNRAIELNNT
                     K"
     gene            49627..49944
                     /locus_tag="KRO40_000385"
     CDS             49627..49944
                     /locus_tag="KRO40_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2091224.1"
                     /translation="MDEKIIEISFNIIGYAGEGKGLAFEAIKEAKNGNIEKAKELLKE
                     SREVINKAHRYQTELIQNEASGNRTEISVILIHAQDHLMNGMNFQQLAEEIVDLHLKL
                     QDK"
     gene            50157..50858
                     /locus_tag="KRO40_000386"
     CDS             50157..50858
                     /locus_tag="KRO40_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2091225.1"
                     /translation="MLRNQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSK
                     ITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESFSSILLSKGHKLSKKTIS
                     IEKIINDTNSQVFSIFGEKCSKITRMYYLDSKPYIFFTHYIPFDENLTVESFNNESSL
                     YMYLYRRNINITRFEDEFFIEESELEVSKALNLAKDILLGRKRKTYDENDNIVELSFA
                     RYNTEVQNYVIKYEI"
     gene            51083..52384
                     /locus_tag="KRO40_000387"
     CDS             51083..52384
                     /locus_tag="KRO40_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2091226.1"
                     /translation="MEKFASFLERKIMPVAAKISNQRHMRAVRAGIIATLPLTIVGSF
                     FTILLNIPIDAYMDFIAPFKAILDIPFRYTVGFLSLYATFGIASSLAKSYDLDTTGVG
                     MLAVMAFLVSTIVPTQVVEPVGGVIEAGRWMDMAKLNSPSLFGAIVTSLITVEIYRFM
                     KEKNITIKMPAGVPVEVSNSFTALLPTAVILMLFWVIRHILGFDISVALSAMLSPLKG
                     FLSGNSLGGGLLTVFLITLFWVLGIHGPAIMGPVIRPIWDMSIAENITAFTEGVSAHA
                     MPNIFTEQFLQWYVWIGGAGATLALVVMFMFSKSQYLKSLGRLGFLPGLFNINEPIIF
                     GAPIVMNPILGIPFIIGPIIMTILSYVLTITGVIPMMVARLPFAMPAPIAAVMSTNWS
                     ILAGILVLINFVISFAVYYPFFKVFEKQQLQREQEEMSENL"
     gene            52521..53615
                     /locus_tag="KRO40_000388"
     CDS             52521..53615
                     /locus_tag="KRO40_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBH2091227.1"
                     /translation="MERRLGISVYPEHSNMEDDKAYIKMASKYGFKRIFMCMLSITRP
                     KEEVKKHFKEIITYARELGFEVILDIAPNIFDILQISYDDLTFFSELNASGIRLDYGY
                     DGSKEAMISFNPYDLKVELNMSNDVAYLDNIITYKPNVNNIYGCHNFYPQRGTGLPYD
                     FFVRCSNRFKKYGIRTAAFVNSKYATIGPWNINDGLCTLEMHRNLDIATATKHLFATG
                     LIDDVIVGNAYASEDELKRMSEVNEYQVVFNVVAEEKTSEVEKIIMVNEQHFRRGDIT
                     NQVARSTEVRKKYAKENFPKHDNKNLFKRGDVVIGNNDFGKYKGELQLILQDCTDERK
                     NKVGRIKEDEIILLDFIEPWSKFKIILEGE"
     gene            53617..54750
                     /locus_tag="KRO40_000389"
     CDS             53617..54750
                     /locus_tag="KRO40_000389"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase/deacetylase family
                     metallohydrolase"
                     /protein_id="HBH2091228.1"
                     /translation="MKIDILIKCGKTVDKSIIDIAILDDKIIEVKNQIDDSKYQAKQI
                     INLDGEKFISAGWIDIHTHCYERLDLYKDYPDEVGIKSGVTTVVDAGTTGALDIGKFY
                     EDTKKYKTNVYALINIAKQGITSQDELSSMMNIDEYELKRAVKKYKDFVVGIKARMSK
                     SVVISNDVEPLKVAKRIKNELNLPMMVHFGSSPPTIEDIFDYMEKGDILTHIYNGKPN
                     GILRGNEVKKEIIEARERGIILDVGHGTESFSMDIAMKSKDAGIFPDTISTDIYIKNR
                     INGPVYNLSTTMEKFIYMGYSLEDIINKVTKNAADAISLKNKGLIKEGYDADLTIFDV
                     VNEEKELQDSLNKSVITSTSIKPRAVVVNGEYLNIGKSIEENE"
     gene            54768..55877
                     /locus_tag="KRO40_000390"
     CDS             54768..55877
                     /locus_tag="KRO40_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DgaE family pyridoxal phosphate-dependent
                     ammonia lyase"
                     /protein_id="HBH2091229.1"
                     /translation="MSSIFEKYSVRRVINASGKMTILGVSTVDKEVIEAIGEGCKNFF
                     IIEELINKTGEYIANLLGCESALIVSSASAGIAQSVGAMIAKDDMSLVYNVNNPKKQV
                     KREIIIPKGHNVDYGVPVEVMIRLGGGEVVEAGYANMCNKEHIIREINENTAAIMYIK
                     SHHCVQKSMLSVLDVVQVAKEYNLPLIVDAAAEEDLNVYYELGADLVIYSGAKAIEGP
                     SSGLVIGKKKYIDNVKLQSKGIGRAMKIGKENIVGLTCAIERYISNDKVTLKEMEDKL
                     NPFIDKINTIKGVSASITRDSAGREILRGEIDFNEDIINKSTQQIINELRSGEIAIYT
                     RDYKANEGKIEIDIRSVTGSDLDTIYNRIKNIVES"
     gene            55942..56682
                     /locus_tag="KRO40_000391"
     CDS             55942..56682
                     /locus_tag="KRO40_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KDGP aldolase family protein"
                     /protein_id="HBH2091230.1"
                     /translation="MNCIPQYYKNRVCLNVLAGSIKNAKEVYDACDGHVLIGVLSKNY
                     STVEAAIEDMKKYSKEIDNAISVGLGAGDPNQSNMVSQISKELQPQHINQVFTGVATS
                     RALLGQNDSIINGLVSPTGKPGFVKISTGPLSSKEKDGIVPIETAIAMMKDMGGSSIK
                     FFPMGGLKTKDEYIEVAKACAKHNFYLEPTGGIDLDNFKEIVQIALDAGVEKVIPHVY
                     TSIIDKETGETKVEDIGVLYKIMKELLG"
     gene            56687..57679
                     /locus_tag="KRO40_000392"
     CDS             56687..57679
                     /locus_tag="KRO40_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HBH2091231.1"
                     /translation="MNILAFGEIMMRLSVPDYKFLTQTNELNYIITGTGLNILSGLKN
                     FGYNTYMLTKLPNNNVGKALSANIRKLGVKDDFITYGGNHIGVYFLENGYGERPSEVT
                     YLNRLNSSFCESKLQDYDIDKCLEGMDIVHICGIAMQLTDSVKEIALELARKSYEKGI
                     KVFFDFNFRQSLNPERTYDDLVNDYKKILPYCHGLFASYRDINKILNIDSLNIKSSSE
                     LIKKEYDIGIVAGTMRRFDDMNNRFIKGYISNDDGYFESREYKLEIYDRVGAGDGYVA
                     GIIYSYLENMKSEDIVEFGVASSVLAHTTYGDNSLVSTGHVLRLMNNEKIDILR"
     gene            complement(57867..58748)
                     /locus_tag="KRO40_000393"
     CDS             complement(57867..58748)
                     /locus_tag="KRO40_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2091232.1"
                     /translation="MNTKQLEYFISVAEKLSFTKTAEKFYISQTAVTQQIKALEEQIN
                     VTLFTRSKRHVELTPAGKVFLSEARTIIKNINDAIAKTQQFAHGFFGTLSIGTLIGYE
                     KNKLQQYLKEFSNTYPNISMDICTNEITELLNLVKNNSMDLAFVINPENQPLKDFEYK
                     TVERYSLVALLPPGHPLYNEDSIDLIELQHDKFIFVKETGDEYGQKSMIQNRYREAGF
                     VPNVVQRSNNLNTIESLVSSNMGISILPSFCVTDTMIERDIAIVPIKEVENRIEVVVV
                     WNKKNTNPALEKFISII"
     gene            59022..60410
                     /locus_tag="KRO40_000394"
     CDS             59022..60410
                     /locus_tag="KRO40_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091233.1"
                     /translation="MEDKFYAKGNGNNGYIKNLEVCSFNNLDGTCGMFQMALYKRDEK
                     YYLYGCCFGGNKKNGVMISDITDPYNPQFIKHFQMLDPKEYPTTTTPKIQIADDLMIV
                     AMSCGSGPGALVDQAKLANIKCEAGIRIYSLKEDPLNPKFLGYWDCGLKHVMGVHRFM
                     YNGGRYVHLSSDCVGFEGLIYRVIDIINPTNPVEIGKWWRPDQYADGYPNRTFDAGAP
                     HCPEFMDKGWLHGPPFVRDGKAYCGYGGAGLVVLDVEDLTRPRCLGELPFTPAFSSRL
                     AGARTHTALPLPGRDLVVVQNEGERFQFFKPDNITDVQAMNNIHMVDVSDPTKPTLIA
                     QFPYPEVPKDFPYPNFNVAGLGKPGPFGPHNLHEPMDNKPWLEQRGDRVYCCYFHAGL
                     RVYDVSDPYYIKELAYFIPPNPNKTPEESYFPGFPGPRLAVTEDLIVDDRGYIIIDAL
                     DDGFYILKMKED"
     gene            60438..61391
                     /locus_tag="KRO40_000395"
     CDS             60438..61391
                     /locus_tag="KRO40_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH2091234.1"
                     /translation="MKILGISFGTKNGNNDTMCKVALKGAKEAGAEVEFIQMSSINIK
                     HCTGCCACVKTLLSGKGSMCVLKDDFEWLLDKMKDADGIVVSDPIFEEGASGLFHTIM
                     DRFGPRADRGNNIIGTKVAEVIGGKIPDSRMLNDKVISFMGIGGSDWGTRVQCEHAML
                     ALIPMWKVIDNAWFPWAKELVMDDTRLVQVHQIGLNIVEAAKDFEKASYQGEEGVCPH
                     CHNRLFYLEPGTKKAICALCGIVGELDTISGKTIFSFPEEQLGHAHDTLPGKFIHGDD
                     IKKMEGHYAEVRKTQEFKERKTSYNFIEPLTKEKQAGVSLG"
     gene            61451..61675
                     /locus_tag="KRO40_000396"
     CDS             61451..61675
                     /locus_tag="KRO40_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091235.1"
                     /translation="MNEKPSFKQIEVILAVIFLVLTYYKVRLTPAFIVIFIPLYLSYF
                     AVSMIVNQIAIKLLEIRQAREATNYNIGNG"
     gene            61668..62180
                     /locus_tag="KRO40_000397"
     CDS             61668..62180
                     /locus_tag="KRO40_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1097 domain-containing protein"
                     /protein_id="HBH2091236.1"
                     /translation="MDRKKKEILTLSMGIALLPPLWAVLAPYIGIKTGAVALICAGLY
                     VTNGNKQKDGLKIMFGFWCGDLWAVLAILIMGYMNFNQNLELFLTLSILGFFAVVIAS
                     LFEKIIFLPSWLCGWAIGLTVMTGENIINLQDICIQIAVAMAVGVWYVGAGVDLFTIY
                     ILSKDRKKGN"
     gene            62212..63066
                     /locus_tag="KRO40_000398"
     CDS             62212..63066
                     /locus_tag="KRO40_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase"
                     /protein_id="HBH2091237.1"
                     /translation="MAMGFEFKIMRSLIYVGLAKEEYRPKLMDWLYRHHIPDSISTFG
                     PYCTKYAFYQAYPTPNEGERFGARKMQLTEHYWLVDEHMPEMANRIMTEYMPMDVLRW
                     QGCIPDVENKRVHENVESGDAGRAVGGDNGCPPFIFAFVPINWEEDFRGKGRTVQDGP
                     NYRWQFMIKYPDGISKEEGEKWFYDEVVPYFTNCCYVNRFVSSKIMINYGATAFDRVS
                     ELWFEGEEEWYKAVVEETKSFIKKPEWAQEEEFPYLKPQFNIASVFLGDIATMDAYSQ
                     YRGYIPMR"
     gene            63600..64394
                     /locus_tag="KRO40_000399"
     CDS             63600..64394
                     /locus_tag="KRO40_000399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2091238.1"
                     /translation="MYTIGQVSKFLGISRDTLKFYEDKGLVNPKKNDENGYRIYNQVD
                     IYDIATINFYREIDIEIKKIQEIRKSKSINNLELLLEEKEQIILKEIEYKKLLLKKVQ
                     LVKEDCDKIKTYFGKYTIKEMKPLEVKGKIKHVTNYEEYEALKENTNNLKKAVTLTDL
                     RRVINFNEEGIIEEKFIIVREVDDYNKIIEGEVLSHPNCIYTIIEDGRWSTGGENIDN
                     KVEDRLREIAIENECELLGIVYVNILLTTYEEGIERIFLEIYAPIK"
     gene            64498..65322
                     /locus_tag="KRO40_000400"
     CDS             64498..65322
                     /locus_tag="KRO40_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2091239.1"
                     /translation="MRTEKSLKRPIASFIILTNIIFLPLFLLVVVTIMLKLPTVISDI
                     ALCISAWSSTFAFMILFKKIYPDKKFLVHVKDRFRNKLKFSTVSIIISIQVLIAVVVI
                     FILASKNHGIMPNFTVSSWGAFIYLFLKNLFAGSLGEELGWRGFVQNHLQKRHSPLKA
                     SIIVGFWWGMWHLPIWFTTGFKGLDLIKYIIFFMIAIISISIIMTTFYNLNKTLIIPI
                     VIHQLFNFLIGIINGDLIELINYYAMLYLIVAIVLVAINPGNALYKRFSKNTTQIL"
     gene            65953..68040
                     /locus_tag="KRO40_000401"
     CDS             65953..68040
                     /locus_tag="KRO40_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2091240.1"
                     /translation="MVVDKEIVSILQILLNSTLITTNGLQEESNSSKRQITYRINKIN
                     DMLKVKNVPLICLRADKDIIVRKETKKAIKEILEKNYSKNTYYFSKTERLLYMYLMLF
                     INMEDISINHFINSIKVSRSTVNLDFKDLIPKLEKKNIKVKNNRINGYYIVGNEMEIR
                     RVLIKNIIETLSNEKSSRVFDIFIKEYNLDSFEEAKKIILKLIKKYEITFVEDRLIEF
                     IYIFIFLKARMYSTRIVTQENVDIPNISVMSSMKEYKFAKELLEVYGSEDKIKPHNIM
                     YISAWILGISVGNYEEDTEDKDVISKIVNKMMTKFGYLSGVYYISQEKIFKQLYSHFR
                     PAYYRLLFKLPIYNPICEKVKEEYKLVYRIVSNAMKEFCGLFGEEIQEEELAYLTMHF
                     ATLFSNKKEFDGFRKRIALIVCSNGVGSSAILHAELTNLFPDLHFIPMSESVGLENIS
                     EPVDIVFTTNYNAEGLKTDVPVIKVSPVMTTKEKYKITREVYIQLGDIFLRQPKIDEV
                     MDIIKKYANVTSESILSSELLAYFTQIENFTSKEGEGPMLSEITNETLVKIKVKAKNW
                     EEAIRQSASVLVENNKVTEGYVDAMINSAKASGPYIVITKHVALPHARPEAGSKEIAI
                     GIATLDSPIEFGNNENDPVKYVFCLSAIDNNSHLRAMSELVELLEEDEFFKVLDSAKE
                     AKEIIDFIKTHEL"
     gene            68055..68342
                     /locus_tag="KRO40_000402"
     CDS             68055..68342
                     /locus_tag="KRO40_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091241.1"
                     /translation="MYKILIACRAGVGSSLMLKIKTQQIIKENNFPIEVEHGSLDSLN
                     GFNGDAVETLIDVAEELKNKNLKFDIIGIHNIVDRNEIKTALEKFLASKEG"
     gene            68369..69640
                     /locus_tag="KRO40_000403"
     CDS             68369..69640
                     /locus_tag="KRO40_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIC"
                     /protein_id="HBH2091242.1"
                     /translation="MEFIISLLSTPAVLLGVVACIGLILQKKSAVEVFTGSSKTLIGF
                     LIFGIGASAMTGALQNFNKLFQHGFGITGVIASPEAATALAQGTYGFAVSCTLILGFI
                     LNLVFARITKFKNIFFTTGHSLFFSCVLVLIMKAHGFDNTITILIGGTILGFMSAALP
                     QFCQPFMRELTGGDEQAIGHFNMIGYGLSGYIGRLFSKHKDDTTETIEFPKWLSIFRD
                     FLMGLSIVMLILFYIATLKAGQAFTQEIAGSTHWLVFPLIEAFTFVAGMSILMSGVRM
                     FLAEITAAFVIISEKYIPGSRPALDVPTVFPYAPNAVIIGFISAYAAGLLAIAIMASF
                     PSIFPVVIIPAAHICFFSGGTAAIFGNTSGGWRGAIAGSFVVGLLLAFLPVILYPVYG
                     TLGIEGATFPNIDYNVVGSILHNILQFIKPI"
     gene            69698..70297
                     /locus_tag="KRO40_000404"
     CDS             69698..70297
                     /locus_tag="KRO40_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH2091243.1"
                     /translation="MENTLSEFLDNISNELSEFIASIDETSINKACELILEAEKNHGR
                     VHVTGIGKPGHVSGYISSLLSSTGTSAYILHGTEAVHGSSGQVVEGDVVIAISNSGET
                     QELKATLKTLKVNGAKIIGVSGNESSFLKNISDIFLFAGVKQEGDCLNKAPRASILAE
                     TIILQSLSVVLQYAKGLNTQQYLKWHPAGSLGKSIREGI"
     gene            70302..71207
                     /gene="dapA"
                     /locus_tag="KRO40_000405"
     CDS             70302..71207
                     /gene="dapA"
                     /locus_tag="KRO40_000405"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH2091244.1"
                     /translation="MKYKGIICAMITPFDENQNINSQATCQLIDYLIEKGIYGLFILG
                     TNGECHVLTDDEKVEFAKIVINHTNNRVPVFVGTGGNSTREVVDLSKRMEAIGASALS
                     IITPYFVTPTQQELILHYKTIANSVNLPIIMYNMPGKTGINIEPESVRELSKIKNIVG
                     IKDSSGKLDNMKAYIEATKNENFSVFSGSDSLILDSLKAGSQGAVAATTNFLTEIGIS
                     IYENFMKGDLEEAQKAQSSIEELRRILKLGTIPSVMKKTIVLNGINVGTARLPVTEPT
                     GEVLEEIKRVVENYRTILNKSSENR"
     gene            71313..71945
                     /locus_tag="KRO40_000406"
     CDS             71313..71945
                     /locus_tag="KRO40_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketohydroxyglutarate aldolase"
                     /protein_id="HBH2091245.1"
                     /translation="MKKMNITKRMSECGALAIVREENLNRACEIAEGCIKGGITVIEM
                     SYTLNNAGEIIQGLNKKYGETLCVGAGTVLDSETARHAILHGAQFIIAPNYNEGVAKI
                     CNRYQIPYAPGCTSLTEAVDALSLGATFIKAFPISDFYGPKLVKVFKTPIPDMPVLAS
                     GGINIENLHIWLENGVDVCGFGGLLTKGSVEDIAKNAKKIREIIKNVKKI"
     gene            72423..74930
                     /locus_tag="KRO40_000407"
     CDS             72423..74930
                     /locus_tag="KRO40_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2091246.1"
                     /translation="MKEDIGLHRMCKKEQATKNEVISEDILKSMSIGVSKHFLDDSFT
                     IIWGNTSFYQLLGYTEEEFLVKFSSLKDYYEQNLYHFESMKNHFLEAYHHGEKSIEYQ
                     ICISANNGDPVWVIMTGILIESQDNEKSMVYILYSKINELKIKQEELSDMEKESTENF
                     KWMMSEYAGNVYISDMDTYELLYLNKHSCNTLQASANELIGRKCYEVIQGRTSPCPFC
                     TNSYLKKDDTYEWEFYNKKLKRTFIIKDRMLNWQGRRVRIELSYDMYSAEYKLAKKDQ
                     ERESILKTIPAGMVRLDARDYLTILWCNDIFLNMIEYTKEQFAEELNNQCGYLFSEDY
                     KRSKKLAQDLKESGDNIVFEAKIYTRSREERIWTVTLCYISGEDSWDGIPSFYSIGID
                     ITKERKQIEKLQHISEKDALTGIYNRAETERQIKKYFEKNLNVMGALFMIDTDNFKQI
                     NDTEGHMIGDIVLTEMASGMKKIMRDSDVVGRIGGDEFTIFMKNISSVKDAEKKAEEL
                     LYMFRHLFQKEKSFLKVTCSIGIAIYPKDGTTFKEIYARADKALYQAKNMGKNNYVIY
                     NQDYFKELEEFDCSSLGTVIDSEKQYAEYPDNLTRYIFRMLYQTDDIDQAINMILEVV
                     GKQFDVSRVYIFENTEDGRYTSNTYEWCNEGISSQMAYLQNSNYQDYEDYEKLFEDEL
                     VFYCRDIHTLSPKLEELFSSQGIHSTLQCAYKEDRVFSGFVGFDECTGLRLWSQEEIS
                     TLSLISQIISMFLQRKKNNKLNQQIQQYQNILDNIDQCICVINKENNFLLYVNKKFKN
                     TYSKFQIGQPYYLDSIDIHKISIIWNKKEAYLCTSMI"
     gene            75272..77434
                     /locus_tag="KRO40_000408"
     CDS             75272..77434
                     /locus_tag="KRO40_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HBH2091247.1"
                     /translation="MKKIIYVLFTIELLIVSLLGLNIVKDNEINNILYNDTTSISVMF
                     KDYKRLNKNYSKWIKDIADENNVTISKYVFNNNEKLSIYTTDTSLNNNIKLKSGKFPN
                     TNSNEFISNINTNNSNQVGKFSTMSKDISILIRDFGKISEVGESGILYISTQNEDTIN
                     KILKELNVDRSIFIARLHDRYVNSNLYLNPSIIRDLILIILCFLATIIHYSISVSREA
                     SILRLNGYSKLDIIARVIKNILRIMILSSVTALLIYIIYILKLNIGVRACLYFAMFSI
                     ICILINILISILIVGFNSRSSKYMLSLNGKKSYGFVNIMHFTLKIVFISFLILSINNC
                     ILNYNMLQTQLGNLSEWDKAKNVYNLTLKDTGEQSLGKEEVIKNAKIKGFYKNLVEEK
                     DAFLIDSTNFEKLEDGSYMYEINSKGKNPEVSQYGKNIKINKNYLKVNPIYSNGKEIF
                     NLIDYDDKTINLLVPKKLQVHENEIKKEFRELFYFEKIEVENMYNKELNRELNKTKKS
                     DLNVNIIYVDNNQSYFTYNSLVMDDNRNLIDDPIAIVDIDNIDDSFYLSYISRCVYFN
                     SKKLDALADISNIIEAQGVEAHIQSLHAVYNEYGLEINKLEKYLNSEIFTIIIIAISN
                     LMITYNIVASYYERNKYKLYIKKIFGYSATARSMLLIVSLILTNIIPIGIISTRVDLS
                     NNIILFGLLILVIEVIVSIVLDKIISNSSFNKIIKGEH"
     gene            77439..78056
                     /locus_tag="KRO40_000409"
     CDS             77439..78056
                     /locus_tag="KRO40_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091248.1"
                     /translation="MISLINISKKFKDKSIIDKFNLEISKGEFVAITGNSGSGKTTLL
                     NIMGLLEKPNSGDIIINNIKNPNSKQIRILQRDFYGYLFQNYALIENENVENNLKIAL
                     KYQKNINHNEKINYALESVGLRKYNKKKIYELSGGEQQRVALARVILKECEVIFADEP
                     TGNLDKKNRDIVFDILKSLNKNGKTIVFVTHDLELSEQADRVIKL"
     gene            78245..78589
                     /locus_tag="KRO40_000410"
     CDS             78245..78589
                     /locus_tag="KRO40_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HBH2091249.1"
                     /translation="MENLPNCPKCNSEYTYEDGTLLVCPECSHEWALGLGAEEDSNII
                     KDVNGNVLNDGDSVTVIRDLKVKGSSSSIKIGTKVKNIRLIHDSSDGHDIECKIDGFG
                     AMKLKSSVVKKA"
BASE COUNT        30363 a         9198 c        13092 g        26158 t
ORIGIN      
        1 ttcctttttt caaggacaag taatactata ccatctttaa aacagtaggt caatactttt
       61 tttatatttt tttataaatt tttttcatat tcttttttca gcttctctac tacctttttc
      121 tctagtctag aaacagtcat ctgtgatatc cctagttctt tagctatact agattgtgtt
      181 ttatcaaaga aaaatctatc tttaaaaatt ttaacttcta attcatttaa agtttcaata
      241 aacttattaa taaaatcttc atactctata cttccaaagt taccttcttc ttttccaatc
      301 ttatcaataa gagttatatc tttatcctct gaatcatcat tacttgatga atccaaagac
      361 attggttgat atccataaga agcctccata gcctctaaaa catcttcttc actaacgcct
      421 atataatcag ctatatcttt tacctttgga tgcttcttat tttcttgttc taatttaatc
      481 ttcgcatcac ttatcttttt gcttaattcc tgtattcttc ttgggactct aagtgtccat
      541 accttatctc taaaatactt ttttatttct cctactatag ttggtgttgc aaagctggag
      601 aactcaaatc ctttctcaac atcatatcta tcaatagcat aaattaatgc caatgaagca
      661 acttgatata tatcttcaaa atcaacacct ttgtttatat acttcttagc taacaatctt
      721 gctaaataca gatgtctttc aataagaata tttctaatgt ctacattttt atttttatta
      781 tataaattaa atagctcttt tgtatccata tttaggtaat gtgtagcatt agctacattt
      841 ttcattaaat atcaactcct aaatatttag tcatttttat ttttgtccct tgattatgtt
      901 ctgattcaat atctacatca tccattaaag ttttaattat aaacaatcca agaccactct
      961 cttttggatt ctctaaatct ggtgtactta ttgagctaac atcatatcct tttccattat
     1021 cttgaatttc tatattaatt gcattatcta aaatattaaa tactatatta aacacatcat
     1081 ctttactgtg ttttattgca tttgtgcatg cttcagatac tgctaccttt atatcttcta
     1141 tatcatctat tggaaaaccc atcttattgg caattccaga tgctgttaat cttattatac
     1201 taacataatc tggatttgta gtaatttcca tctttatagt ctcacaagcc aaagtttatc
     1261 cctccacttt aaatatttta tctagacctg ttatagtaaa aatctttctt acgttactct
     1321 taggatttac tatgtatatc tctttttcat ttatttttaa tttttttaat acacctatca
     1381 tagctcctaa gcctgttgag tctatataat ctaaatcttt aagattaatc tttacatcta
     1441 acatattttt ttctattaaa gcatgtaaat gttcctttag tttatctgct gtagaaacat
     1501 caagttctcc atcaagacaa acattccaaa atttattttg tgaatctaaa tttgaatcaa
     1561 tattcataga catgtaaaaa cctcctattt ccttttaata attttaaata tatttcctat
     1621 actcaatatt ttattaatta cataaactat atcatctatt ccctttgata ttgatgatgc
     1681 attttcaaca atatcttgta tatgtctttc attataatct acaatcttat atgccttttc
     1741 aacaacctta tttatgctgt ttagagtttt agctaaataa attgctacta taagagcaga
     1801 gcttcctact aacactgctc caatttgcca cccccatgca ttcattagtt aacatctccc
     1861 tcatcatcaa agcttttact tattactata tcttcttctg aaatctttat atcttcttca
     1921 ttattatcat catccactaa atttattatt ctctctttaa catcattaaa tgtttcatgt
     1981 agaacttctt ttgggttttc tttgacatca ttaaacttct cttttgtttc ttttcttagt
     2041 tcagaacctt ttttaggtgc aaaaaacata ccaaatataa accctaaaat agctcctaat
     2101 aataaaaatc cacctttttt acaacttctt ttattgcaca taacaattac tcctttcaat
     2161 tttaaatttt tatctaacta cattatacaa aaagaatagg atatttatcc tattcttctt
     2221 caatatttat tttggcaatc gaaactacat tgacttcatc attcgtcttc attaatttaa
     2281 caccacttgt aactcttcca aacagtgata tttcattgac tcttattcta ataagaactc
     2341 catcagaatt tataatcatt atctcatcat cttcgttgac catatctgca cctacaattg
     2401 taccagtttt ttcagatata ttataagttt taattccttt accagctctt atttgacttc
     2461 tatactcttc tatatttgtt ctctttccaa aaccattctt acttacaact aacacatctg
     2521 tacctttact gcaaaggttc atagacacaa caaaatcttc tttacttaaa gttatacctt
     2581 ttacacccat tgctgttcta cccatatatc ttatatcatt ttcatcaaat cttatagaca
     2641 taccttcttt agttactaaa agtacttctt gttttccatc tgtaagttct actccaataa
     2701 gctcatcatc atctcttaaa cctattgcaa taagaccaga tttatttata tttttgaact
     2761 cttctctctt agtcttttta acaatacctt ttttcgttgc aagtaataaa tattcatttt
     2821 catcattacc atcaataggt attagagtag caattttctc atctgctgac aattgaagta
     2881 aattcactat agcagtacct ttagcctgtc tcttaccttc tggtatttca tatgcattta
     2941 atttaaatac tctaccttta tttgtaaaga ataatagtct actatgagta gttgtagtta
     3001 ccaagtgcct tacaaaatct tcttctctag ttgtaagtgc tgaaatacct cttccacccc
     3061 ttttttgact cttataagta tcagatggaa gcctttttat atatccaaag tgagtaagag
     3121 ttattgctat ttcttcatca cttataagat ctctcatatc tatttcgcct tcagcatgtc
     3181 ttatttctgt tcttctctca tcagagtaat tttcttttat tattgtaatt tcatccttta
     3241 ttacatttaa aagtaatctt tcatcagcta aaatctcttt taatctattt atcttcttga
     3301 ttaaatcttc atattcagct tctatcttat ctctttctaa acctgtaagt ctttgaagtc
     3361 tcatatctaa tatagcttgt gcttggattt cagttaattt gaatttttct attaaaccta
     3421 gcttagcttc ttgcccagtc tttgaagctc ttatcaagct tataacagca tctatattat
     3481 ctaaagcaat ctttaatcct tctaaaatat gtgctcttgc ttcagcttta tttagttcaa
     3541 atttagttct tcttgtaaca acatcttctt gatgtttaat ataatgatat aatatttgtt
     3601 taagatttaa aactcttggc tgaccatcta caagtgcaag cattattata ctaaaagtat
     3661 cttccatttg agaatgttta tacaaattat ttaatactat attagcatta gcatccctct
     3721 ttaattctat aacaattctc ataccatttc tattactttc gtctcttagg tctgatatac
     3781 cttctattct cttttcttta actaactctg ctattctttc aacgagttta gccttattta
     3841 cttgataagg tatttctgta actattattt gctgttttcc ttttggtagc tcttctataa
     3901 aagctctaga cctaacttta acttttcctc ttccagttct gtatgcttct gctatacttt
     3961 cttttcccat tataattgca gctgtaggga aatctggtcc ttgaacaaat tttattaaat
     4021 catctacact acactctgga ttatctatca aatatacagt tgcatcaatt acttctgcta
     4081 aattatgtgg aggtattgaa gttgccatac caacagctat accatttgag ccatttacta
     4141 ataaattagg atatctagct ggcaatactg aaggctcttt taacgactca tcaaagtttg
     4201 gtttaaagtc tacagtttcc ttttcaatat ctctcagtag ttctaatgat aatttactca
     4261 ttttagcttc tgtataacgc atagcagctg gtgaatcccc atcaacagaa ccaaagttac
     4321 catgaccatc tactaaaagt gctctagttg aaaaatcttg tgccattctt accatagcat
     4381 aataaacagc agtatctcca tgaggatggt acttacctaa aacgtcccca acaatacgag
     4441 ctgacttcct atatggttta tctggagtta aatttaactc actcattgaa tataatattc
     4501 ttctatgaac tggctttaaa ccatctctaa catcaggaag agcacgtcca gctataacac
     4561 tcattgaata atcaatatac gattttttca tttcttccgc tatttcaata gggagtattt
     4621 tgttattttc ttccatgtat actaatcccc tctctctata tatctaagtt tctaacaaat
     4681 cttgcatttt cttctataaa ttcttttctt ggagcaacct tatcacccat aagcattgaa
     4741 aatacttcat ctgcaattgc agcatcttct acagtaactt gtaataaagt tcttgtctca
     4801 ggattcatag ttgtttccca taattgctct gcattcatct ctccaagacc tttgtacctt
     4861 tgaagttcaa caccatttct tccaatttca tctaataaaa tatttaactc tttatctgag
     4921 taaacataat gttccttctt ttgctttgtc actttatata aaggtggctg tgctgcataa
     4981 acatacccct catctataag aggtctcata tatctaaaga agaatgttaa taataaagtt
     5041 cttatatggg ctccgtctac atcagcatcg gtcataatta taattttatg atacctagcc
     5101 ttatctatat caaaatcttc tccaatacca caaccataag ctgttatcat attttttatt
     5161 tcatctgaag atagtatcct atctagtctt gatttctcaa cattaagtat tttccctctt
     5221 aatggaagta tagcttgact atttctatct ctaccttgtt tagctgaacc tcccgctgaa
     5281 tccccttcga ctaagaatat ttcactttta gatggatctt tttctgcaca atctgcaagt
     5341 tttccaggta aagatgtact ttctaataca ctttttctcc ttgttaattc tcttgctttt
     5401 tttgcagctt ctctagctct ttgtgctctt aaagctttat caactatgat tcttgctgtt
     5461 gatgggtttt cctctaggaa agaccccagt tcatcaactg ttacactatc aactatacct
     5521 ctcataaagc tattacctag ctttgtttta gtttgacctt caaattgagg ttctggtaat
     5581 ttaactgata ctactgctgt aagaccttct cttatgtctt caccaagtag gttaacatca
     5641 ttttccttta aaaatttatt tctcttagca taatcattta cagttttagt aagagctgct
     5701 ttaaatccac ttaaatgaga accaccttcg tgtgtattta tattgtttgc aaaagaatat
     5761 atgttctctg tataaccatc tgtatattgc atagctagtt caacaaaaca atcatcaacc
     5821 tttttatcta tataaactat gtcatcatgt ataccagttc tagatttatt taaatactta
     5881 atgtattcta ccaaaccacc tgtatagtga aattcttttc ttttttcttg tccttctctt
     5941 ttatcttcaa atactatttt tattccttta ttcaagaaag aaagttctct aagcctatac
     6001 tccaatgttt catatttaaa ctctatttca tcaaatattg tctcatctgg cataaattga
     6061 atcattgttc ctttatcttg agattctcca actacttcaa gcttagatgt tggcaatcct
     6121 ttctcatatg tctgcttata tatctttccg tttaaataaa cctctgctac catccatttt
     6181 gacaatgcat taactacaga aacaccaact ccatgaagac ctccagatac tttatatcct
     6241 ccgcctccaa actttcctcc tgcatgaaga ttagttaata ctgtttctaa agttgattta
     6301 ccagttttag gatgtatttc aacaggtata cctcttccgt tatcttttac taaaacactg
     6361 ccatcttcat taatagatac atatatgtct gaacaatatc cttgtaaagc ctcatctata
     6421 ctattatcta caacttcata aactaagtga tgtaaacctc tagggcttgt actaccaata
     6481 tacatacctg gtctttttct aacggcttct aatccctcta atacttgtat ctgacttgca
     6541 ccgtattctt gtttcattta atttcctcca ttctctatgc taataacatc gccattttca
     6601 atattaaata ttgtaacatt tttttcatca aatatttttt tatgtgaaac ttcagcactt
     6661 gttataaaca tttgaacatt gcttaaatta tttactaaaa gtttttgtct tgcttcatct
     6721 aactcactaa aaacatcatc taaaattaat actggatatt cttcaacttc attttttatt
     6781 aattctatct ctgataactt taatgatatt gaagcagttc tttgttgacc ttgtgaacca
     6841 aaaagtcttg catctaaatc atttatgaat atatttaagt catctttgtg tataccatat
     6901 ctggtagtct tagattctat atcattaggt ctattcgatg acaacttggc taaaaattta
     6961 ttatatactg tatctatagt atcttcatca gttatattta tttgattttt atatcgaatt
     7021 gataatcttt caactccatt agtcaaattc atatgcatat tttcagatat attagctatc
     7081 ttttttataa agtctctacg caaaatataa atataacttc catactttgc taacgtatca
     7141 tcatatacat ctaataaagc ttcatcaaca tgtatatttt taagcaccct actcctttga
     7201 gaaagtgttt tattataatt ggtaagatat ttataatatt taggtataat ctgactaatc
     7261 tctttgtcta taaatgccct tctttcttta ggaccctctt taaccaacct taaatcctca
     7321 ggagaaaata taacaacatt taagttgcca agtagctctt gtatcttttg taaaggaact
     7381 ttatttattc ttatcccttt tttatctttt ccaataatta gctctattag actatattta
     7441 ttatattttg aaaaacttcc tccaatatat aagttttcac tattaaatct aaccatttct
     7501 ttatctttgt tagtcctaaa tgattttcca aaagaaagca tataaataga ttctactata
     7561 tttgtctttc cttgaccatt tttaccaaca agtagattta ctttcccatt aaattccaga
     7621 tgcaactttt tataatttct aaaattaaca agttgcaaac ttttaagttt cacaaaaagt
     7681 tctccttttt ttacaatact tttattttag ttccttctat ttcaactata tctcctgatt
     7741 ttatcttttt tcctcttctt aattctattt catcatttac tgtcactaaa ccttcttgaa
     7801 ttaaaaattt tgcatgacct cctgttgatg caatctctgc taatttaaga aattgatcca
     7861 actttatata ttctgattct atagttattt cagtcataat agttcctcct tgtcactatt
     7921 ttaaacaaat tcctattgat acactaaaag tatattatac cataaatatg cttataaaag
     7981 gagttgtcta agattagaaa aattttctac aaaagacaac tccttcatgt ctgctatata
     8041 tttgatgata ttcttactgg aagcagtaag taaatataat taacatcatc tgttggttta
     8101 attatacaag gatttacatt tgtagtaaat tctataaata tttcctcatt atctatattt
     8161 ttcaaacctt cgataaaata tctagaattg aaagctatat ctaggtaatc tccatctaaa
     8221 tctatttcaa cttcttcata cacatttcct ttttctgtat tagaagtaat tgccattact
     8281 ttatctctta tagataactt tataagatta tttttttctg attgagacaa taaagacgct
     8341 ctctctatac tatttaaaag ttccttagta tttaatttaa ctctgctgtt atgttctctt
     8401 ggcaataatt ttttataatc aataaaatct ccttcaagca atcttgtaat aattttcgta
     8461 tcattaatta taaaaatagc atttttttcg ttaaatccaa ctttaacatt atcctctcca
     8521 gaaagcaaac tatttacatc tataagtgtc tttccaggaa ttatgacttt tatattttca
     8581 gttaaactat caaccgaaca actttttaca gctaatctat atccatcaat tgctactaaa
     8641 tttaagtttc tatctacaat ttctaaaagt tctcccatta aaacaggttt tgtttggtcc
     8701 tgtgagatag caaatacagt ttgtttaatc atatttttta ggatttcttg aggtatgcta
     8761 tataaatctt cttcatttaa ttctggtaat ttaggaaatt cttttgctgc ataaccttta
     8821 attttaaatc ttgaatttac acaatttatg taaatattat tttctgaatc agtttctatc
     8881 tcaacaaagg aatctggtaa ttttctaatt atatctccaa atagccttgc atctacaaca
     8941 acatcacctt tttctatgat ttctgcttgt acataagttt ctattcctat ttcagcatca
     9001 tatccagtaa gttttaattg accttcttct gtagatataa gtataccttt taataattct
     9061 attgttgttt ttccattaat agctttttga gcaattccaa ttctatttgc taggattttt
     9121 tgattacaaa ttattttcaa tgtggataac ctcctctggc tttttatata taaaaataag
     9181 ttaaaatcat agtagtaata gtagtaggtg ttgttgataa tgttaataag tatgtataac
     9241 attataaata caaagatatt aacatgtgta taagatgtta atatctttgt tattttagac
     9301 ttgataattt gttaataatt tttgttcaaa aaaagtatta acaggttatt caagagatat
     9361 aaacatacaa ttgtgtataa attatccctt caaatctgat ataattttgt ctattttagt
     9421 cttaatttct tcactttctt ctatatcctt agatactttg tcatgagcat gaattactgt
     9481 tgtatggtct ctacccccaa actcttcacc tattttagga agggataaat cagtaagctc
     9541 gcgcgttaaa tacatagcta tctgtcttgg ataagctatt gaacgtgttc tttttttaga
     9601 attaaaatct tccatcttta aattgaatac agaagatact ttttctttta ttctgagaac
     9661 atttatttct tcatttttag aagttgttat aatatctttt aaagcttctg tagcaagatc
     9721 aaaagatatt accctattgc taagagaaga ataagcaacc actctagtta atgcaccttc
     9781 tagttccctt atgtttgact taatattttt tgctatatat gacataacct catttggcac
     9841 atctatacgt tctagttgag ccttttttct aagtatagca attcttgtct caaagtcagg
     9901 tgcttgaata tcagttataa gtcccatttc aaatctcgat cttagcctat cttctagtgt
     9961 aggtatgtct tttggcggtc tatcactaga tataattatt tgtttgtttg cttcatgaag
    10021 agtattgaat gtatggaaaa actcttcttg agttctttct tttcctgcta taaattgaat
    10081 atcgtcgatt agtaatacat ctacgtttct atatttattc ctaaattctt cgtttttatc
    10141 gtcttttata gagtttataa gttcattagt aaatttttct gaagaaacgt aaactacttt
    10201 tgagtctttt ttttgactaa caatatgatg acctatagca tgcattaggt gagtcttacc
    10261 taatccaact cctccataca aaaaaagtgg gttataagct ttagctggag attctgcaac
    10321 tgcaacgcat gcagcatgtg caaatctatt gctattacca ataacgaatg tatcaaatgt
    10381 gtattttgga tttagattgg ggtaaagaac tctataattt aaatctgtgc tatcagaatt
    10441 taaatcagca acctcttttt cgctcaatac aaatttaata ttatattttt ttaatgacag
    10501 ttgactaata gcatcttcaa ttaaatgtaa atatctattc tctaagatat ctttattaaa
    10561 atcactagga gccagtaaga ttaaatcatt aagatgtatt tttaatggta cgatgttttt
    10621 aaaaaaggta ttaaaactta ctgaagttaa gtcacctttt attaattgta gggttttgtc
    10681 ccataaagaa actatatcca taatataaac ctccgaacag aataattaat attttccaca
    10741 aagttattaa cagaaaagca aaaatatata taaattttac agaataacta aatttatgga
    10801 taatggtgtt gataaattaa taatagtata aattattaaa aaaatatgaa aagatataaa
    10861 caatatgtag ataaagttat aaataacata aacatacaat aaatggtgat tataactaga
    10921 gtattgtcag taatcttaaa agttatacac aaaagtatcc acaagctgtg aataatttct
    10981 aataagttga taacatttat gcacattatc aacaagtata tttataatat caaaatatat
    11041 gtcaaacttc aatgatttgt aactaattta tccacaatat taactaattg ttgataaaaa
    11101 tataaacatg ttaaaattac tttatttgtg tatataattg aaaaaaataa tttagaataa
    11161 aattaaatag atttttgcta gtattttcaa taaaaaaaat acataatata tatatggtag
    11221 attttgtgat ataagcgtcc caaaaactcg ttgacaacag tagtaaaagt atttataatt
    11281 atatgtgtta tgtttacttt gagggtaaag ttattatttt tataaacgga aaataaaatc
    11341 tgaaaggcgg tgcaaaataa tgagtaaaag aacttatcaa ccaaaaaaga gacaaagaag
    11401 taaagaacat ggtttcagaa aaagaatgaa gacgtctaac ggaagaaacg tgttaaagag
    11461 aagaagagct aaaggaagaa atagattaac tcattaatta caaaagggcc gctgcaaagg
    11521 tggccttttt gtgtaaataa ttacaattca tagctgtgtt tatggaggtt aactatggac
    11581 tttaatagga ctaaagggtt gaaaaaagac tctgatttta gaaaagtata taaacacggc
    11641 aaatcttttg caaacaaata tttagtaata tatatactta aaaataaatc agattatagt
    11701 agagtaggta tttctgtttc aaaaaaagta ggaaaagcta ttactaggaa tagagtaaga
    11761 agattaataa aagaagccta cagattaaat attgatgaaa aaattaagcc tggatatgat
    11821 atagtattta tagcaagggt atctagtaag gatgctactt ttaaagacat agacaagtct
    11881 ataaaaaatt tagttaaaag aacggatatt tctatttaat tgtatgctat aaatatggag
    11941 gttaatgact ttgaataaaa taatttatat attaaaggaa ataagtaagt atttatcgaa
    12001 tttatgtatt tatttagtga gattttatca aaagtatata tctcccttaa agggacctac
    12061 ctgtagattt tatccaactt gctcacaata ttcaatagag gcgtttaaga aatatggatt
    12121 tgtaaaaggt atgtatttaa cgataagaag aattttaaaa tgtcatcctt ttcatccagg
    12181 aggttacgac cctctaaaat aaaagagagt aactattagg aggtataaaa aaattgaata
    12241 taataggaaa tttcttagga ttgattctta aggtaatatt tgaatttgtt aatcattatg
    12301 gtatttctat aatacttttt acgatacttg taaagattat tttattacca ttaacaatta
    12361 agcagactaa gtcaacaaag gcaatgcaag atatacaacc tcgtataaaa gagatacaag
    12421 aaaaatataa aaataagcca gaaaaacaaa atgaagaaat tgttaagtta tatggagaag
    12481 ctaaaattaa tccactatct ggttgtttac ctttattaat acagtttcct atattaatag
    12541 gattatttag cgttttgaga gaaccagttg ctcatggcgt ttttgcaaac aaagctgcat
    12601 ttttagcagc tgacaatggg tttttatgga taaaaagctt aacatcacca gattatgtat
    12661 tagcagtatt ttcaggagca agtgcatatg tcatgcaaaa agtaatgaca ccaaaagatc
    12721 agttacaagg ctctatgaaa gtaatgacat atgtaatggc aggtatgtct ttctattggg
    12781 gatttatatt cccagcagga cttacattgt actggacagt aagtaactta ttctcaatag
    12841 ctcaatatta cttaataatg aatcctttaa aagctaaact ggctgctaac tctaaggagg
    12901 aaaaagttaa tgagaaaaag cctaaaatta ataaaaagta agagtaaaga ggaagctata
    12961 agtaaagcta tagcagagtt gaatttaaaa gcagaggata tagaagtaga aatacttgaa
    13021 aatccaagta aagggttttt aggttttata ggtgctaaag atggtactta tgaaattttt
    13081 gttatcgaga gggaagtaga tgtagctaaa aattttatag aggtaatgtt gaaaaatgca
    13141 aatgttgatg ccaaagtcaa tgtatctcaa aaagataatt taatcatggt tgatattgaa
    13201 ggcaaagaag ctgcaagttt aattggtaga agaggggaaa ctttagattc tattcaattt
    13261 ttgactggat tagctcttaa taaaataaat aaagattctc atacaagagt acttgtagat
    13321 atagaaaatt atagatcaaa acgagaagaa tctttaataa gatatgctaa taaagttgct
    13381 agagaagtag cgaaaacaag aaaaactaaa aaattagatt atatgaatcc atatgagaga
    13441 agaataatac attcagctct tcaaaatgac aaatatgtaa ttacatatag tgaaggaacc
    13501 gatccatata gaagattagt aattgagtgt aaaagataaa gtcaacctcc taaacattag
    13561 ggggttttat tttttaatat tattaaatca ttaatgattg gttaaatgta aatctatatg
    13621 taaaaaatta tgaattaaga ggtgataaat ttgtttatag atgatacaat tgcagcaata
    13681 gctacagcac ctggagaagg tggtataggt atacttagaa taagtggaga aaaagctttg
    13741 aaggttgcag aagaaatctt taaatctatg tctggaaaga gtattgaaga atacaataag
    13801 agaacattaa tatatggaaa tatagtggat aatgaaaata taattgatga agttttattg
    13861 gcatatatga aaggaccaaa ttcctataca ggagaagatg ttatagaaat taattgccat
    13921 ggtggattta tttcggtaaa gaagatatta gaattaatac tatcaaaaga tgttagatta
    13981 gcagaggctg gtgagtttac taaaagagca ttcttaaatg gaagaataga tttatctcaa
    14041 gcagaggctg taattgatgt tataaaagcc aaaactgata tagctcatga agttgctcaa
    14101 aatcaattag aaggttcttt atcaaagaag ataagagaat tgagagataa agtcactgag
    14161 atattagctc atgtagaagt tgctatagat tatcctgagg aagatattga gcatataaca
    14221 tatcaaactc ttaaagaaaa aactgatgaa cttaaaaaag acattaaaaa attatatgat
    14281 acagctgaaa gtggaaaaat acttagagaa ggcttaaaga cggtaattgt tgggaaacca
    14341 aatgtaggta aatcttcact acttaattct attttaggag agaatagagc aatagttact
    14401 gatataccag gaactactag agatgttata gaagagtttg taaacataaa aggtatacct
    14461 ttaaaaattg ttgacacagc aggtataaga gatactgatg atattgttga aaaaataggt
    14521 gttgaaaagt ctaaagaatc atttactagt gcagatttga tagtaatggt tttagatgca
    14581 tctagaaagt tgtcagaaga agatatagag atattagaaa aacttaagga taaacaaaca
    14641 atagtgctgt taaataagaa tgatttgaaa caagagattg aagaagaaaa aatacttaaa
    14701 tatgtagaaa ataatagtat aataaaaata tcagctttac aacaagaagg aatagaagaa
    14761 ttgcaagata aaatagagtc tatggtatat aaaggtagta tcaaaaataa ttctagttta
    14821 gtagtaacaa attcaagaca taaagatgca cttagtaaag catataaatc tgcaacagat
    14881 gctttaattg ctttggaaca aagtatgcca tttgactttg tagaagtcga tttaaaaaat
    14941 atatgggact atcttggata tattaatggt gatacagtaa cagaggattt actagataat
    15001 atattccata atttctgtat tggtaagtaa tgtacaaaag taaacttgtt tttattatag
    15061 agatttttaa aaaatttgaa gtgtttctca tgaaacatta attttgaaaa gaaaggaatt
    15121 ataaatgata aagtttgaag caggaaaata tgatgttata gtagtcggag caggacatgc
    15181 tggatgtgaa gctgctttgg ctactgcaag aatgggatat aaaactttga taataacaat
    15241 gtctttggat tccatagcat taatgccttg taatccatca attggaggga ctggtaaagg
    15301 tcaattagtt aaagaaatag atgccttagg cggtcagatg ggattaaata tagacaagac
    15361 atatatacaa agtagaatgt taaatactgc caaaggtcca gcggtacact ctttaagagc
    15421 acaagcagat aaatttaaat atcatgaaga aatgaaaaag acattagaag atgaaccaaa
    15481 tcttgatata gctatggatg aagttgtaga aatacttcat gaaggaaatg ttgtaatagg
    15541 agttggaact aaactaggat gttcatttaa atctaaagct gtaatattgg ccactggagt
    15601 ttatctgaac tcaaagatat atatgggtga agttgcattt tatgaaggtc ctaatgcatt
    15661 ggggtatgca aaatatctta cagatagctt agttgagctt ggccttagaa tgagaagatt
    15721 taagacggga actccagcaa gagttcatag agatagtata gacttctctg taatgtcttt
    15781 acaagagggt gatgaaaaag taactccatt ctcatttatg aatgaaaata tagaaaaaaa
    15841 acaagaacct tgttatttaa caagaactac agaagaaact caaaaagtta tactggataa
    15901 tttaaaaagg tctgctatgt atagtggagt aatagaaagt actggtccaa gatactgtcc
    15961 ttctatagaa gataaagtag taagatttag tgataaaaca tcacatcaat tatttataga
    16021 accagaaggg ttaaatacta aagaaatgta tatacaagga atttcaacta gtttaccttt
    16081 tgaagttcaa ttagatatgt acaaaactat aaagggactt gaaaattgta agataatgag
    16141 acctgcatat gctattgaat atgattgtgt tgacccaact caactaaaaa taagtttgga
    16201 aataaagggt gttgagaact tatttagtgc agggcaattt aatggaactt ctggatacga
    16261 ggaagcagca gctcaagggc ttatggctgg tataaatgca gttagaaaga tagaaggaaa
    16321 agagccattt gtattagacc gttcagaagc ttatataggt gtcttattag atgaccttgt
    16381 tactaaagga actaacgagc cttacagaat gatgacatca agagcagaat atcgactata
    16441 tttaagacaa gataatgcag atatgagatt aactcaaaaa ggttatgata taggattagt
    16501 taaaaaagat agatatgaaa ggttcctaaa taaaaaggct gctgtagaga aagaatttga
    16561 aagactaaaa aatgaaagag ttacaccaaa agaagtaaat agtttgttag aagaaaaagg
    16621 agcaacacca ataaaggttg gaatatctct atatgaattt ttaaagagac cagaggttac
    16681 ttacgaattg cttgaagaat tagggaaagg cgctggagaa gatgtttcaa gagaagttaa
    16741 agaacagtgt gtaataataa ctaaatatga aggttatata gagaaacaat tgaaacaaat
    16801 agaccaattt aaaaaacttg agaataaaaa gctggatgag aaaataaatt attcatctat
    16861 agaaggtctt agattagagg ctagacagaa actagatgat ataaaaccta tttcaatagg
    16921 gcaagcatct cgtatatctg gtgtttctcc agctgatata tcagttttac ttatatacct
    16981 agaacaaatc agaagaacta gaggtggcaa aggtgaataa tatagaactt ctgaaaaacg
    17041 ggattgaagg ttttaatata gatacgaatg acagtatgtt agaaaaattt aaaatctata
    17101 gagagatatt agttgactgg aataaaaaga tgaatcttac tggaatagaa gatgaaaaag
    17161 aagtgtatat aaaacatttt ttagactcta tttcagctgt aaagaatgga tatataaaaa
    17221 atgggatgtc tataatagat gttggtacag gtgctggttt tcctggaata ccattgaaaa
    17281 tatgtttaga tagcttagaa cttactttgt tagattcgtt aaataaaaga ataaactttt
    17341 tagaggaagt tagtagagta ctagagttag ataatattac atttatacat ggaagagctg
    17401 aagattttgg taaaaatgaa gactataggg aaaaatatga tgttgctacg gcaagagctg
    17461 ttgctggatt accgattctt atggaatttt gtgtaccatt tgtaaaagtt ggagggtatt
    17521 ttatttgctt aaaaggtccg aatgctaatt tagagctaga agaatcacaa aaggctattg
    17581 atgttttagg attggagtat attgaaaaaa tagatgtaga gttaccagag gtagatttaa
    17641 atcataatat attagttttt aaaaaagtga tggaaacacc agttaagtac cctagaaaag
    17701 ctggtaaacc agccaaaaat cctattaagt aatgaaaaat ttattattgg taagcttaat
    17761 tatttctcag gaaataatta agcttactgt aaaaaaacaa aaataaagga attattaaag
    17821 tagatgcaga aataaatttg tatgtacata tagagaacaa aaataattta tatctaaaat
    17881 aagagaggta tgttatggaa gataaaagag ttatggagat acctatagaa gatgtagttc
    17941 caaatccata tcaaccaaga aaaatatttt cacaagtttc attggaggaa ttgagcaatt
    18001 ctataaaggt atatggtata attcaaccta taacagttag agcaaaagat ggcaaatatg
    18061 aactaattgc aggagaaaga agattaagag cagctaaatt agcagagctt aaaaccatac
    18121 cagcaattat aaataatatg aacgatgaat cttctgctgt tctagcgtta ttagaaaatt
    18181 tgcaacgaga agacttaaat ttcattgaag aagcaattgg ttatgaaaac ttaataaaag
    18241 aacatgcttt tactcaacag caattagcag aaaaattggg caaaaatcaa tctactgtag
    18301 caaataagct tagaatatta aagcttccaa acgatataaa aatgaagcta atagagaata
    18361 atttaacaga aagacatgct agagcatttc ttaaactacc aagtgaagat ttaatgcaaa
    18421 gtgtgttaga caaagtcata aaaaatgaat tgactgttaa aaaaacagaa aaattgatac
    18481 aagatgtatt agaagaaact aaagttcaag aagagcctga taaaaaacag aatataaagg
    18541 gtgctatgag tataagaatt tacataaata ctataaagca ggcctttgat gctatatcaa
    18601 atacaggaat tgatgctaag tataatgaaa tagataaggg agattatatg gaagttgttg
    18661 taaaaatccc taaaaaatag agattactgc ttaccagtaa tctttttttg taatataagc
    18721 cttgtaatat aaattgattt atagacatta tttatactta aaaaacacct attcaacatt
    18781 taaaattaat ttaattctta aaggggggaa catcatgggc aaagttatag ctgtattcaa
    18841 tcaaaagggt ggagtcggga aaactacaac aaatgtaaat ttaagtgcta gcttaggaac
    18901 tttgggaaag aaaatattag tattagattt agacccacaa ggaaatacaa ctagtggata
    18961 tggtattaat aaaaacgaag tagaaaatac aatctatgaa attatgttag atgggttaca
    19021 tattaaagaa gcaataataa gtactgaatt tgagaatgta gatgtagttc catcagctac
    19081 tgaactatca ggtgcagaga tagagcttac atctaaaact aatagagagt atattttaaa
    19141 aaattccata aaagcggtaa tagatgaata tgattatata tttttagatt gtccaccctc
    19201 actggggatg cttacaataa attgtttaac tgctgtagat agtgttttaa ttccaataca
    19261 atgtgaatat tatgctttag aaggtgttag tcaattaatg gagactataa aattagtaaa
    19321 atcaagatta aatgctgata tagaaattca aggtgttgtt ttaagtatgt ttgatggaag
    19381 agctaattta tcaatacaag tagttgaaga agttaagaaa tactttaaag gtagtgtata
    19441 tacaacttta attccaagaa atgtaagact tgcagaagct ccaagtcatg gaaaacctgt
    19501 aatttattat gataaaagat gtagagggtc tgtagcttat ttggagctag cagaagaatt
    19561 tatagattta gaagaggagg aatggtagta tggagaataa gtctaaaaga agtaatagat
    19621 taggtagagg tcttagtgca ttgataccag aaattaaagg agaaacttca gaaaaagaaa
    19681 tagtcaacat agatatagac aaaatatatc caaacgaagt tcaacctaga aagcaatttg
    19741 atgaagaaaa gataaaagta ttgtcggatt ctataaaaaa ttatggtgtt ttacagccaa
    19801 tagtggttaa aatggatgaa aataataaat atatgataat agctggagaa agaagattta
    19861 gagcatcaaa acttgcaaat aaaaatcaaa tacctgctat aattaaagat atagatatga
    19921 aagatataat ggagatagcc ttaattgaaa acttacagag ggaagattta aattcaatag
    19981 aagaggctct agcatataag agtttaatag agcattacaa tgtaactcag gaagaaatat
    20041 cagaagctgt tgggaagagt agacctcata taactaatac actaagactt ttaaatcttg
    20101 gacaagatgt tatagaaatg atagacagtg gtagaatcac agcaggccat ggtaaggctt
    20161 tattgagaat tgcagataaa gatttgcaac ttcaaatagc gaaaaaaata gaagaagaag
    20221 aactttctgt aagagaagtc gaaaatatag ctaaaaaaat atctgaaaat aaacaagaag
    20281 aacctaaaaa atctaaacct aaggatgtat ttattttaga tgttgaagat aaacttagaa
    20341 atatatttgg aacaaaggtg aatatttcta aaggaaagaa aaaaggtaaa atagagatag
    20401 aatactataa tgatgatgat ttaaatagta ttgtatcaat gcttcttgaa tagaacaaaa
    20461 atataaaaca gagaggaaga ttgttatgat ttatttagat aatgctgcaa ctacatatcc
    20521 aaaaccagaa agagtgtata atgctgtttt agattgtatg aaaaattatt gtgcaaatcc
    20581 aggtagagca ggccataaac ttgctatgag agctgctagg gagatatatg atacaagaga
    20641 gaatatagct aagttgttca atgtaagtaa tcctatgaat atagtattta catctaatgc
    20701 aacagattct ttaaatttag cgataaaagg tgtattacaa gaaggagacc atgtaataac
    20761 aacgtctatg gagcataatt cagtaataag acctataaaa gcattggaaa aaaggggtat
    20821 tgaaaatact gtagtaaaat gcgattatga gggattttta gattatgaag atttagaaaa
    20881 atcaataaag agtaatacta aactgattgt aacaacacat gcgtctaatg tatgtggaac
    20941 tttaatagat ataaaaaaag ttggagaaat agctaaaaaa cataatatac tatttttagt
    21001 agatgcatca caaacagcag gtgtttatga tatagacgta aatgaatgta atatagatat
    21061 gttggcaatg ccaggtcata aatgcttatt tggacctcaa ggaacaggta tattatatgt
    21121 aagagaaggg ttgaacttaa atatattaaa agaaggtgga acaggtagta aatcagaaga
    21181 aatagttcaa ccagagttat tcccagataa atatgaatca ggaactcata atactccagg
    21241 tatagcaggt cttaaccaag gtatactatt tatatttgaa agaggaatca acaatataag
    21301 acaacatgaa gaagaattat gtcaatatat gatagacaaa ttagaggaag taccagatat
    21361 aaagatatat ggaccaaagg acagtaaaaa aagagcatca gtaatagctc taaatatagg
    21421 agatatggat tctggagagg ttactttctt attagatagt gattataata tagcgactag
    21481 atcaggaata cattgttcac cactagcaca taccacttta ggtactttaa aacaaggtgc
    21541 agtaaggttc agtataggat atttcaacac aaaagatgag atagataaag cagtggaagc
    21601 tttgaaaaaa atttcaaaaa ataaatagca tgagatttaa taatatagaa ataaaaaagg
    21661 ggatatttca aaataaaaat ttgaatcatc tccttttttg tacaaaaaag aaaaggggtc
    21721 cctaagaacc tctaatctat ttgataattg ttttaagaag ttactttaag taatctcctt
    21781 cttcaagaac tatatgacca ctttcgtaat tagaaccatc aacagtaatt tttatttgtt
    21841 caacattcat attttttatg taagtacgag caactgaatc aagcattaaa gtttctgcat
    21901 cactacctaa gtttgacttt gtaaagtcag agctaacatc taatatacca gtttttacac
    21961 catcaatgtc ttttgtagta aatgaattta attttgcaga ttctggaaca actttaagtt
    22021 tttgaagttc ttcaaataaa gtgttctcat caattttatt taaatcaact ttattttcaa
    22081 ttaaatctgt cttatctaca tcaaaagagt aaatagtagc tgattgagct ttagtttctt
    22141 cttttggagt aagtttagct ttgttattag gaacctcttt ttcagtattg ttttcttctt
    22201 ttggttgctc aacatttgta ttgctcttag tttctttttt agatgaatca cttccatttt
    22261 gagcattagt acaaccaact gcgaatatag atatagataa tatacttaac actaacatta
    22321 ttttcttatt tttcataaaa atttctcctc tcttaaaaac tattcttata tataattata
    22381 gtcgttatga gcaaatatat gaatacaaaa tagtaacaaa tttaaaaaat gatttattta
    22441 aattaataaa actcaaaata aactaaattt tagtcatttt tatgggaaat catttaatgt
    22501 acagtgaaaa tattgtaaaa taaaagtagt gtttttaaaa taaatataag ttataattat
    22561 attataaaaa aatgtcttca aaaggtggga atagtatgga aattttgagc ttaggagaaa
    22621 agattaaaaa gttaagaaaa gaaaaaaaca tgacattgaa agaattagct ggagatagga
    22681 taacagcagc acaaataagc catatagaga gagataaatc tcatactagt tatgaactgt
    22741 tggaatatct aggcgataag ctagatgtaa gtgtagaata cttattagag accaaggaaa
    22801 tgcaatcaaa aaagataact gataatttaa tactacagag cgaaatttat ataaaagaaa
    22861 atgaattaaa caaggctgag gaccaaataa aagaagtttt agatatatgt aagagatacg
    22921 atttaatgga gaactatggc agatgtaatt ttttaatggc taatattaat ttgaaaaaat
    22981 ctaattataa tgatgctata gaaaactttg aaaaggcatt gtacttcttt ataaaaaata
    23041 gtgatagtga aaatatactt aagtgttatt taaacatagg gaaaatatat atgcaggaag
    23101 acttttataa aggtgctata agccacttta attttgcaga ggaaattttg tcagagaata
    23161 aatttgagga tgttaacata cacaaggaac tatatagtaa gatggcatat tgttacataa
    23221 aactagataa tccaaatatg tcattgaagt acatagaaaa gataaatgaa atagataata
    23281 gaaatgatag aaaagaagat gtcgatattt tggtgttaaa agcaaataat atgcttgaga
    23341 ttggaaaata tgaagaatca agagattact ttaaaaaagc actaaaaata cttgagagtg
    23401 aggataataa aactggatta gcaaatgtgt atttaacaat ttgtgatgtt tacagaaaaa
    23461 taggtgaaac agatagagta cttgaatatt cacaaaaggt atatgacata aagaaaaatg
    23521 atgaagatga atacatgatg tcaggattat ttaagataat agaagcatat atagataaag
    23581 aagattatga tttagctaga aaatattgta agatagcctt agcttcatca ataaaaaata
    23641 aaaataaatt caatgaatat aaagcattga gattctatgc taatatgtat aaaaatcaga
    23701 atgaagtaac tcttgcaatt gaatatctga ttaaatgcat aaaaatagta tcagatttag
    23761 gcaacaatag aatattggcc aatttatata tagacttagg tcaattatat tcaaatatat
    23821 caaaagaaaa agagttagaa tattatcaaa aaggtgtatt tatgtacaaa aacttagaaa
    23881 taatgtaggg taaataaacc tataagggta tagaaacaat ctataacaag caagataata
    23941 tctatgataa aatataaatt gtatgaatat ttttaaggag atgaatcaga caatgagtat
    24001 aaaaatagat gcgagagggc ttgcttgtcc taaaccagtt ataaatacaa aaagagaatt
    24061 ggataaccta gaagaaggtg ttgtagttac aatagttgat aatgaaacag ctaaggagaa
    24121 tatattaaaa cttgctaaat ctttaagttg tgaagcaaat attgttgacg aaaaagagaa
    24181 ttttatatct atagaaatta gaaaaggtaa aaatatacta gataaacaaa atgttgtaga
    24241 taataaagaa agtgaattag acaatacatg tatatttata tcttcagata agatgggact
    24301 tggaaatgac gaattaggaa aagtgttaat aaaaggattt atatatacat taacagaatc
    24361 taaaccttat cctaagtatg tacttttagt taatggagga gtaaaattaa gtgctgaaaa
    24421 tgaagaaacc atagaaaatc taaaaatact tgagaatatg ggtgtagaag ttttatcttg
    24481 tggtacttgt ttagattatt ataatttaaa agacaaatta caagtaggta cagttacaaa
    24541 tatgtatact atagttgaga cattaaagaa tgcatcaaat accatttcta tataatgtat
    24601 gtatgtttaa taatataaaa ctaacaataa agattaactc aaatagatag tcagaaagga
    24661 ttaagtaatg aatcaaatgt atatagtgtc atttaattcg acacatcatg cgataagatc
    24721 agaaaagtta tttggtgaaa atagtctaaa agtaatggct cttccaacac caagagaaat
    24781 aacagcaagt tgtggaatat caattaaatt ttcttttgaa gatatggaaa agataaaaac
    24841 tattttggtt gaaaataatg tagatataaa aggaatttat tgtataagta aattagaaaa
    24901 tggttcaaaa gaagtagaga agttagatta ggaggctaat tatttatgcc aatggattta
    24961 aaaataggtg atattgttga attaaaaaag caacatgcat gtgggtgtaa agagtttgaa
    25021 atcataagaa cgggaatgga tataaagata aaatgtacta aatgttcaag gctaataatg
    25081 cttgatagag agaccttaga aaagagagta aaaaagctaa taaaaaagtg ataaaaattt
    25141 aacacttaaa aaatgtcaaa taccgtatat taatatccaa aattttggta taataagaat
    25201 tgaagaaaac attttcatgg gggtgcttta attatggcag ttaaatatgc aaaaagaatg
    25261 caaggattac aaggatcaga aatacgtgag cttttaaaac ttactcaaca accacaaata
    25321 atatcttttg ctggtggaat gccggctcca gagttatttc cagttgagga aatgaaaaaa
    25381 gtatcagttg cagtgcttga agaaaatgga agatcagcta tgcaatatac tacaacagaa
    25441 ggatatgaac cattaagaga aaaaatagca gctagaatga atgataaaaa caaaactaat
    25501 gtaaacaaag atgatatatt agttacaagt ggttctcaac aaggtctaga ttttgcagga
    25561 aaagtattca ttgatgaggg tgatgtaatt ttatgtgaaa gtccatctta cataggagct
    25621 ataaacgcat ttaaatctta tcaacctaaa ttcatagatg ttccaacaga ttctgatgga
    25681 atgataatgg aagaattaga aaagatacta gaaacaactg atagaataaa aatgatttac
    25741 gtaatacctg acttccaaaa tccaacagga agaacttggc cacttgaaag acgtaaaaaa
    25801 ttcatggaaa tagtaaataa atttgaaata ccagtaatag aagataatcc atatggagat
    25861 ttaagatttg aaggagagac tttaccatct ttaaaatcaa tggatacaaa aggattagta
    25921 atattcttag gaactttctc taaaatattc tgcccaggat acagattagg atggacttgt
    25981 gcttctccag aaattttatc taagtttaac tttgcaaaac aaggtgcaga cttacaagca
    26041 tcaactatat ctcaaatgga agtaagcaaa tttatggata tgtatgacct agatgcacat
    26101 gttgacaaaa taaaagcagt ttatgttaaa cgtagagatg taatgcttaa gactatggaa
    26161 gaagagttcc cagaaggatt agtatttact catccagaag gtggattatt tacatgggta
    26221 gagcttccaa gtaatttaaa tgctaaagaa ttaatgccaa aatgtttaga taagaatgtt
    26281 gcttatgttg ctggaggagg attcttccct aatggtggta gagaaaatac tttcagactt
    26341 aactattcaa atatgccaga agaaaaaata atagaaggta taaaaaatat agcagctgta
    26401 ttaaaagaag ctatgggtgt agaagcttaa ttaaaaataa taacttatat ataatacaag
    26461 ggatggttgt tgccatccct tgtttgtttg aaaagtatat aattcacctt atactaaact
    26521 ttgtccaaaa tttaaattga cagaaataag aataaatgat aaaatgtgta ggtatgagat
    26581 tttagtctca tttctctgct ctaagagtgt agagccgtta agtccaaagg gaggtgaatt
    26641 atagtgagaa attatgaatt agtttatgtg gtaaagccaa actctgatga agaagtaaga
    26701 gaggctatac taaacaaagt taaggaagtt gttgcaactg acggagaaat agttaaagtt
    26761 gatacttggg gaactaaaaa attagcttat ccaatagcta agtttacaga aggtttctat
    26821 gtattagtta acttcaaatc agcagtagac gttcctaaag agatagacag aaacttaaag
    26881 ataaatgaaa acgtaataag acacatgata gttgttgctt aataactggt tttattataa
    26941 aaaataggtg gtgtttttat gaatcaagtt gtattagtgg gaaggttgac tagagaccct
    27001 gaattaagat acatcccagg tacaggaaca ccagtggcat cctttacaat agccattgat
    27061 agagactatg taaaaaaaga tggatctaaa gaaactgatt ttatacctgt tgaagtaatg
    27121 ggtaaatctg ctgaattttg tgctaactac ataactaaag gtagattagt agcacttcaa
    27181 ggatctataa gagtagacaa ttatcagaca caatcaggtg aaaagagaac ttttacaaaa
    27241 gtaagtacta gatcagtaca agctttggat agtaagaata aatcggaaaa ttcatataga
    27301 gagagtgctc cagcttttga gccaagcttt gaacctcaag gtttagaccc acaaggtttc
    27361 caagctatag atgatgacga tataccattt taaaaaggag ggaaaaaagt catgatgaat
    27421 aaaaaaagac gtaagaaaaa aagagtttgt caattttgtg ctgacaaaaa cgctaaaata
    27481 gattacaaaa gtactcaaag attacaaaag tatataactg aaagaggaaa gatattacca
    27541 agaagaatat ctggaacttg tgctaagcat caaagagaat taacagttgc tataaaaaga
    27601 gcgagaaata tagcactttt accatataca ttagactaaa aaaatgagcc ttgtgctcat
    27661 tttttattat atgtatttat atatctaaat gaggcgagct ataaagctcg tttttttgtt
    27721 tatatactta aatatattat tatttatgat ataatattat atattaagga gggttgtaaa
    27781 cgtgaaaata gataaaggtt ctgagataac gagaaacata aagataatag aatggatgaa
    27841 aacagaaata ttaatgagtg taagtgattt gtttaattta ttgtttaaag gggtaaaacc
    27901 attagatgaa gcaattcaag atactttagc aaatataata atgataacat atctcttagc
    27961 aaagagatta ggaattagtt ttagagatgt ggattataaa gtcaaggaaa aaataaaaat
    28021 tggtatagat gaggaccata gcgttgaaag atggtatgga gatttatcta atttaaaaaa
    28081 acatatggat aatagggagt gatattaaat tgaataataa aattagacta tctaaggcaa
    28141 tgtctataat agttttagct ataataatcg ctttagtaat agcctatatt ccaatgctag
    28201 gaatatttag tatgttagca gctgttccat atgtaattat aggtgctatt actgatagaa
    28261 agtattctct tatatctatt ttggttacat tttgtgtact gattctattt gcagacattt
    28321 cttatgcatt aaatatatgt ataatgtatt ctttaccagg tatagtaata ggaaagatgc
    28381 taaagagaag ctttgaacaa gaggacagta ataaattcga accgatatat ggtggaacca
    28441 taatatttgt actttcaatg cttgtatatt tttttgtatt aaagacattt ttaaatgtga
    28501 atctattaga tgaagtttct aagatgatat cagaaattgt aaatattcaa aaaaatagtt
    28561 tttctgcaac tgaacttaaa gtgtttgata aaatgaagcc agatgagatt gtaagttatt
    28621 ttacaaatat gctaccaatg atgttatttt tacaagggtt gttatcagcg tttgtcacat
    28681 attatttgag tgtatttttt ataaaaagga ttacaaagat gaatataaga tttcctaagt
    28741 ttgctgattt ttatttaccg ggaaatgcta tactcacaac tttcttactt tatttattag
    28801 tcttatttat tcaaattatt ggttcaaaat tatatacaga attaataatg actaatttac
    28861 agctagtttt taatttaatg tttgtaattc aaggtatagc agtttgcatt tatttcttaa
    28921 agaaatggat aagacaggga ccaaataaaa ttatgttttt ttcagggata attttatgtt
    28981 tatttggatt tatgggaata tcttttgttg gtatggtaga tagtataatt gactttagaa
    29041 aggtaagaag ctataaatcc acttaggagg atagaaatga gtaataaaca aacctttaaa
    29101 ttaaatatgc cagaaataaa tttatatata attgttattg gtatttctag tataattttg
    29161 ctttattaca acttgtatgt agggtgttta tttttctgta tttttgtata tatggttttt
    29221 cacaattgga gaactactaa tattagacgt catgaatgga cagagtatat tcaaaattta
    29281 tctttagata tagatgaaac aactaaaaaa gccataataa atcttccaat accattatgt
    29341 attttagaat ttgatggaaa tatatcctgg tataatggaa agttttatga tatgattggt
    29401 caaaaagatt tacttgataa aaatatagag gatatagtta aaaatcttaa tttaagaaaa
    29461 gtattaaatg aaaataaaga gatgtacaca gaaataaact ataaagaaaa agaatataca
    29521 ataatttata atgttataaa aaatgatcaa gaaaaaaatc ctaaatattt gatgatatta
    29581 tactggatag acaagactga atatttaaaa gtaaaacaaa attatgatga tgaaaaaaat
    29641 gcaatgatgc taatacaagt agatggatat gatgaagtat taaaaagtgc agcagaagat
    29701 aagagagctt taattaatgt tgaagtagag aaaatacttt ctgctttaga attaaattca
    29761 aatggtgcat tgagaagaac ttcaaaagac aaattcttct tggtaatgca taaaaaagag
    29821 ttaaaaaaat tggaagctga gaagttttct attttagata caataagaca tattgattat
    29881 ggaaataatc ttcctgttac tataagtata ggaattggta tagatggaga tacattaaat
    29941 gagaacctaa aacttgctac gggtgctctc gatttagcac ttggtagagg tggtgaccag
    30001 gctgttgtaa aaacaaaaga taaatttgtg ttttatggag gaaaatctaa agctgtagaa
    30061 aagaaaacca aagtaaaatc cagattaata ggtcatgctt taagagaggt tatacaacaa
    30121 agtgaccaag tttatataat gggacataaa tatcctgata tggatgctat gggagcagca
    30181 gttggtgttt atgatatatg taaatcctgt aacaaaactg caaacatagt tttacaatct
    30241 gtaaatgaat ctatagaaat atttataaat aaaataaatg aaaataatta ctataaaaag
    30301 ttgtttattg gaaaagagga agctattgac aactgcacta aaaatacatt agttgtagta
    30361 gttgatactc atagaccaaa ttatactgaa tgtgaagaac tgttaaagct atcagagaag
    30421 gtagtagtta tagaccatca tagaagaggt gtagagttta taaatgatgc agtgctttta
    30481 ttccatgaga tatatgtatc ctcaacgtgt gaaatggtta cagagttagt tcagtatatg
    30541 gatgaagatg taacaataaa taaacttaca gctgaagggc ttttagcagg tataagtcta
    30601 gatactaaaa actttgcatt caaaacaggt gttagaactt ttgaagctgc ttcttacctt
    30661 agaaaagttg gagcagatac tatagaggta aagaaattct tcaattctga tgtaaaagat
    30721 ttcataataa aagctgaaat aattcaaagt actaaaataa ttaataatag aatatgttta
    30781 gcatattcaa gtactgagat agatagtata aatgttataa tagctcaaac tgctgatgag
    30841 ttattgaata tcaaagaagt agaagcttcc tttgtattag gtgaaaaaga tgatactata
    30901 tttataagtg cgaggtcttt aggacaaata aatgtacatg tacttatgga aaaattagga
    30961 ggcgggggac acatagatat agctggagca cagttaaaaa atgtttctct aaaagaagct
    31021 tataagatgg taaataaaat aatagaggag tatttggagg aggaagaata gatgaaagtt
    31081 atattattaa aagacgtaaa aggaactggt aaaaagggag aaatgaaaga agtaagtgat
    31141 ggatatgcaa gaaatttctt atttcctaaa aagatggctg tgcaagcaga tagtgtagca
    31201 ataaaagaat taaatgaaaa gaataaatct aaagaaataa aagcacaaaa agagtatgaa
    31261 gaagcagttt tattaggtaa gcaaatggaa gaaattaata tagaaatata ttcaaaagca
    31321 ggagaaggtg gaagattatt tggttcaata acttctaaag aaattgctga gcaattaaag
    31381 aaacaaaaag acatagatgt agataaaaga aaaatattat tagatgaacc gataagatct
    31441 ttaggttcaa ctttcgtaga aataaaaata catcaaaaag taactactaa aataagagtg
    31501 gatgtaaaag aaaaacagta ataactagag gtgattaaga tggaagatat gacgagaatt
    31561 cctcctcata gtgtagaatc agaacaatca atattgggtt ctatacttct agataaagat
    31621 gctataataa cggttacaga aactataaag cctgatgatt tctataaaga ggctcacaaa
    31681 ataatatatg aatgtatgat aactttaagt aataaaggtg agcctataga cttgataaca
    31741 ttaacagaag aactaagaaa acaagggcat cttaatgata ttggaggaat cagttatatt
    31801 acaagtcttt ctactatagt accgacgact tcaaatgtaa aatactatgc tgatatagta
    31861 aaagaaaagt ctgtacttag aaagcttata aaagcttcta atgaaataat aaatctagga
    31921 tatagtggag caactaagat tgaagatgtt ttagaacaag ctgaaaagag tatatttgat
    31981 atatcacagg agaaaactag tgatgatttt aaatctataa acttagtttt gatggatgcc
    32041 tatgatatga tagaaaaatt atacactaac aagagtgatg tcactggtat aactactggt
    32101 tttaaagatt taaacaaaaa aataaatggt cttcaaagga ctgatttaat attaattgca
    32161 gctagaccag caatgggtaa aactgccttt tctttaaact tggttcaaaa tgcagcctta
    32221 aaaggtgatg cctctgtagc tgtatttagt ttagagatgt ctaaggaaca attagtacaa
    32281 cgtatgttat cttcacaatc tagtgtagaa ttaaaaaaaa taaagactgg aacacttaat
    32341 gataatgatt ggcctagaat tatagatgct atggcagtat tatcagatgc caaaatacac
    32401 atagatgata ctcctggtat aaaaatatca gaactaaggt caaagtgtag aaagttaaaa
    32461 atagaaaaag gactagattt agtgcttatt gattatcttc aacttatgga aggtgaaggt
    32521 aataatgaaa gcagacaaca agagatatct aagatatcaa ggtcactaaa aatattagca
    32581 aaagaattaa actgtcctgt agtagcacta tctcagttat cacgtgcacc agaacaaaga
    32641 gcagaccata gacctatgtt atctgattta agagagtctg gagcaataga acaggatgca
    32701 gatatagtta tgttcttata cagggacgaa tattatcatg ctgattctga gagtaaaaat
    32761 ataggagaag taataatagc aaaaaataga cacggtgaaa ctggttctgt ggaacttgtt
    32821 tggcttggtg aagttcaaag atttggggat aagttgagag acctataatc taacgaatat
    32881 ccacagaacg tcctttcttt ctacaggaaa aatgtggata catgtcacta aatatgtcca
    32941 aacattgaaa tttagctaaa aaactatcca cactatccac agatggcctg ttgataagtg
    33001 tgaataagta gataaagcaa gcttttggct tgctttatct gtgtataaat attaattatt
    33061 aggaggaata atatggaaaa aataagctta aaatatatat atcccaatat aattaaagta
    33121 cttgatgaaa taaacttatt tagagtaatt gacaataatt taagagagtc tattgttgtt
    33181 tatgctaata atgtggataa tcagtatcat ataaacatga ctaatacaaa ctttggaaac
    33241 ataattaaca tatgtaaatt agaaaaactt ttagatgtgg ataaatttat ggaaaaagtt
    33301 ataaaatatg aaaaagaaat aatagagaaa gaagagtttt caaaaataga agaatatatg
    33361 ttaaatattg gagaatacta aaaaagttga aaaaaatacg aatgtttgat agaataagta
    33421 agtaaagtgt tcgagagtat ataaaatata gaggtgaatt acatgaaaac agttgcaatt
    33481 gttggttctc aatggggaga tgaaggtaaa ggtaaagtta tagattatct tgctactcaa
    33541 gcagatgtag tagtaagagg gcaaggtgga aataatgcag gacatacatt agttgtagaa
    33601 ggtaaaaaat acgcattaca tctaattcca tctggagttt taaatccaaa tacagtgaat
    33661 ataatcggaa atggaatagt gtttgaccct aaaggatttt tagaagaatt ggaaatgttt
    33721 aaaacggata atataagtac agaaaatata aaaataagtg atagagcaca tgtcatattc
    33781 ccatatcata aagaactaga tgcattgtca gaagaagcca gaggcgattt aaagataggt
    33841 acaacaaaaa aaggtattgg accttgttat atggataaaa cagagagatc tggtattaga
    33901 atatgtgact taatggataa agataaattt gctataaaat taaaagctca aatagatgct
    33961 aaaaatgaaa tagttaaaaa tatatatgga aaagaagaat tatttgattt tgaaactata
    34021 tataacgaat atctaggata tgcagaacaa ataagaaaat atgtggcaga tacgtctgtt
    34081 attgtatatg atgcagtaag agcaggtaaa aaagtattgt ttgaaggagc acaagggact
    34141 ttattagatt tagatttagg aacttatcca tttgttacat cttctcatcc aacatctggt
    34201 ggatttgcaa ttggtgcagg tataggacca aatatgataa aagacgttgt tggtatagta
    34261 aaagcatata ctacaagagt tggagaagga ccgtttgtta cagagcaaat aaatgaaact
    34321 ggagataaga taagagaaca aggacatgaa tttggggtaa ctactggtag accaagaaga
    34381 tgtgggtggt ttgatgcagt tatagttaag tatgcagcta gagttaatgg attgactagt
    34441 atttcattta tgttacttga tgtattaact ggatttgata agataaaagt ttgtacgtct
    34501 tataaaatgg gcgataagat aataacggat ttcccagctt cattagatga tttagcaaaa
    34561 tgtgaacctg tatatgaaga attagatgga tggaatgaag atataactca aatagataac
    34621 tttgatgacc ttccagaaaa tgcaaagaaa tatgtagcaa aaatagaaga actagttgga
    34681 gtaagtgtag atatggtttc tgttggtcca aatagagctc aaactataat aagaagaaat
    34741 atatttgctt aatattttat caattaaata atttaaaata gttgaagaag agtatctcaa
    34801 gataatgttt atagttatta gagatgctct tttatatttt acttacattg attttttatt
    34861 aagttaaagc tacttataca tattctagct gaaattaaag ttgaatttat gtagatacat
    34921 ataggttttt taaaaagaat tttgttgaaa ataaatggct aaagatgatt ttaattatat
    34981 tctaaaaaaa gtaaaaaaaa ctattgacta aaaattatat agacgctata atataacttg
    35041 tgagtgaaag aaacgacgaa aaaagtcgaa aaaatgtggt ctattagctc agtcggtaga
    35101 gcacctgact tttaatcagg gtgtcccgcg ttcgagtcgc ggatagatca ccaaaatatg
    35161 gctcgttggt caagaggtta agacaccgcc ctttcacggc ggtaacaggg gttcaattcc
    35221 cctacgagtc accagtatgg gactatagct cagctgggag agcacctgcc ttacaagcag
    35281 ggggtcacag gttcgagccc tgttagtccc accaaatttt gaattagaga taaatactag
    35341 attatatgct ggtgtggctc aacggtagag cagctgactt gtaatcagca ggttgtaggt
    35401 tcgattccta tcaccagctc cacaaagtac ataaattcaa attaatataa ttttctatgt
    35461 tacaggatac ttttaagtat ctttttttaa tttcattttt attgtattaa aaatgaaatt
    35521 aaacatacaa caaaattttg aattacttgc aatgtgatag ttttaaatat aaaatttaga
    35581 atcattctag catagtatta tgtaatatag caaatttaat ttatagtatc aataaatata
    35641 gactactaag aatgtaaatg atttgttaga ttaagataca ttagatatgt aaatagaaaa
    35701 ataaaaagta tgttttaatt tatgtgatat aagttttaaa cagagaagca agtttgctct
    35761 tacctctcta tttaaaaata aaaaaatgtt ttttaagggc tattttattt aaatctttcc
    35821 catctcaaat catctccagt aaattctaaa atcctaaact tatctaatat tctagagaga
    35881 gttctttgag tgtaagtatt tcctatttga gatggtgtta agttggttga aataatgatt
    35941 tttttaccag caacaagtct tgtatttaca atattgaaga tttctccact agtaaaagaa
    36001 ttattaagtt cagttccaag gtcatctatt attaataaat cacaatcaaa caagttttta
    36061 taattatctt cacttatttg attatttgtg tctcttctaa atttataatc ttcaagaata
    36121 tctaaaattc taaaagaagt ttgatagatt acaacattgc ctttatctaa caattccttt
    36181 gcaatacaat tgcacatata ggtctttcct agtccagtag aaccataaaa cagtagattt
    36241 tcactattat ccttcttaaa atcatgaaca aaattttcgc agatacttaa attatttagc
    36301 atattttctc taggagatat ttcaccatca gagcctttct taggagaaaa tatattcaag
    36361 ttaaaattcg aaaaattttc ctgacttaaa atcctatcta aattagacat tttataagct
    36421 tcatttacaa tttcttgttt gaggcaagaa catttttctc cattaggtaa aaatccttta
    36481 tctttacaag aaatacattg aaactttatt tccaagtaat caagaggtat gttactttca
    36541 gctaaaagtc tttctttctt tacttttaaa gactctatat tctctttagt cttctttaca
    36601 atttcatctt tagacttagg atttaaaagt actatcttag ctaaactgag acctatttta
    36661 gaaatttcat catctataga ttttatctca gggattctat tatatacctc attttttcta
    36721 tgttctaata agagttcatt atcatctctt ctcttagcat atttagcaag tatttttctt
    36781 attttatcct cattcattta atcacctact taaacttttc tttttgactt tttttaataa
    36841 tctcatcgag ctcatcagag gtatactgag tgaatgtttc gttgaaatta tgaaacttag
    36901 tttttttgta agtattgttg ttttgagtag tattaatctg cttcttatta atattctcct
    36961 taactatacg ttcttcctct ttttgcttta aatcatttaa attttttata tttttttcat
    37021 tccaattttt aattatacca tttatataag atatacttgg gtttgaaata ttcttagact
    37081 tagaacatgc atttattatc aaatctatat ccatattaaa tttatcaaac caagtgtcca
    37141 taagttcttt ttctgatttt gatggttgtc ttgaaaatcc caattcattg aaaatcgttt
    37201 tatataaaat atatcgttca cttcttacca aaaagctttc ttcaacatct tttggcgtat
    37261 ataaatttga atcataccaa tttctaataa tgccttcaat gtatttaact ggctttgatg
    37321 taccagtttt atctttgacg tattcatatg cgcaaagtat catatcgggg ctcatattgt
    37381 atttattcat tatatccata atactcatct tttcgcttgg gtcgagatat cgcccaacta
    37441 ttttatttat agaattaaac atttttctaa tacttggatt ttcagaagta gatacaacct
    37501 tatctgtatt agattttata gatgaattat tgcttaatat attctcaata tagaaatttt
    37561 ttaaatctaa aaattctatt gaataattaa aattatcata ttctccattg tcatgtattt
    37621 ttataatctt cttttcttcc cagaatttcc aagcagataa cacatcagac aatggtatat
    37681 ttaggttttt ggctattgaa ttattgtcga acttaggatt agaagtaata tcacatgctt
    37741 gtctatatcc taaaagataa acttttacgt ataacccgtc cgccattggc ataaatatat
    37801 ctataaagat attgggaata gtgatttcac ctaaatctat ttcattgctt tctttaaaaa
    37861 acattttatc acctcagatt aaattatatc attttttata ttatatttgt ctgtaaacaa
    37921 ataaaaggtc acaagattag catgtaaata ttttctaaaa gtattcattt tgaaaaggag
    37981 gagatatttt ggttataaaa ttcaaccaaa aagtaagaag aacattatca gtagcgattc
    38041 tatttatggt attaataata ggttgcttta tagaaaagga tgacagttta gagacataca
    38101 aagaaaaaac taattcaaaa ataaatcagt ataatatgga tgttatattt gatgatgaga
    38161 ctaagaggtt aatgtgcaat cagaatgttg actacataaa taatacaaaa tcaaacttag
    38221 ataaaatata tttccatata tatccgaatg ctttttccaa gaaagatttt gctccttttg
    38281 aaaaaagtga aatgacaagg gcttatccta atggatttaa cgaaggatat atagatataa
    38341 agaatatatt aaataataat agtaaaatgg agtataaaat taaaggagac aaaaatgaca
    38401 tattagaaat agaattaggg aaagagttaa aaccaaatga aagaatgtca ttagatataa
    38461 aatataacgt aaaaatacca aattcaattg gaagatttgg atatggagaa aatactataa
    38521 atgttactaa ttggtttcct atagcttgtg taaatgatga aaggggatgg aatttaaaga
    38581 gttatgaaac tattggcgac ccattttata gtgagactag cgattttcat gtgaaactat
    38641 tgattccaaa taaatataaa attgctcata caggaaaact tattgatgat aaacatgata
    38701 ataagaaaat gctatatgaa atagaagcgg aaaacgttag agattttgca tttatactaa
    38761 gtagcaaatt taatgtaaac aaagtagatt caaagggagt agctatcaat acatataatt
    38821 taaataaaaa gctttctaaa aaagcaactg aagtggcaaa agattcaata aatatattta
    38881 gtgaattatt tggaaagtat ccttacaaag aattttctgt tgtagcaagt gactttttta
    38941 taggggggat ggaataccct atgcttgtta tgatagacca aagtttatat aatgaaaaaa
    39001 atgaattttt actagaatat gttattgccc atgagacagc acatcaatgg tggtattctg
    39061 ctgttggaaa tgatgaaata agtgaaccct ggttagatga agcacttact gaatattcta
    39121 caatagttta ttttgaacaa aagtatggta aagatatggc aaacaagctt ataaaaacta
    39181 tggagataca gacaaaaagt tatttgagcg aaaatatatt taagccagca aatgagtata
    39241 aaaattctac tgaatacagc ttgaatgttt atacaaaagg cgcaatagca tttaatgaaa
    39301 taagaaaaga agttggagat aaagtattct ttgagacttt aaatgagtac tataataaat
    39361 ataagcataa aaatgctaat ggaagagcct ttgtggaact atggaatagt aaaggtgtag
    39421 atataaataa gattataagt gaatgtaagt aaacagtgaa tgtaagtaaa ttttgtgtag
    39481 agtattaaat tttatttaat actctgtttt tttggtataa tataatttat aaggcagaaa
    39541 aagaggtgaa ggaatgctaa agtattgttc agtagggagt ggtagtagtg gtaattgcca
    39601 ctatataggg tataaaaata ctaatatact agtagatgca ggattaagtg gcaagagaat
    39661 aactacaggt cttaaagaca ttggtgtaga tgcagataaa ttaaaaggaa tatttataac
    39721 acatgagcat gttgaccata taaaaggagc aggtatatta tcaagaaagt ttgatatacc
    39781 agtatttgct aatataaaaa catggtgttc tatgaaggac aaattaggtg acatcaaaga
    39841 taagaatatg aaagtatttg aaaatgataa aacctactca ttaggtgata tcatagtaag
    39901 acctttttca atagaacatg atgcgtctga cccagttgga tataattttt atacagagag
    39961 tgatgaaaaa atgtctatag ctactgatat aggatgtata actcaaaata taaaaaaaca
    40021 tctatataaa tctaaattag tagtattgga atcaaattat gaccctaata tgcttatgat
    40081 gggttcatat acatatgctt taaagaaaag agtaatgtca agtactggtc atttatccaa
    40141 tgaagatgca gctaatttct gcgttgaact tattaatgaa ggtacagaat ctatattatt
    40201 agcacatttg agtaaagaaa ataattttcc tgagttagcg tatgagactt caaaaggagt
    40261 attagcatca aatgatatag tagttggaca agatgtaaaa ctagatgtac tatcacgaaa
    40321 tgatgtttct aatgtttatg agatgaagta gaggtgaata actttgctaa agagaaattt
    40381 tgaaaatgtt gaggataata aaattttata ctctataaag cagggtatga ttttagcgat
    40441 acctgctatt atgactggtt caacggctct tgtaattttg aatcttccaa taaaggctta
    40501 tcaagaatat ttatcaggct tgtttaatgg agaggttaca aatattctta actttataaa
    40561 tgattctact ttaggaatta tttcattaat aatattatta acaataagct atagttatgg
    40621 aaaaatatat gggagcaagt atacagtact tgttcctata gttgcaatgt gctctttttt
    40681 agtattttca catggtaatg agcttaattc ttatatagaa atatttaaaa caaagtggtt
    40741 atttacatct ataattgttt ctatgacatc ttctgtattg tttgtaaaac ttacagaatc
    40801 ttttgttaca agtgtaaagt ttcatacaga aggggctgat gcagacttta atatggtagt
    40861 ttcggctata gttcctttca taatagtagt atttttgttt tctattttta gagtgataat
    40921 gataagtcta attggcagtt caaactttca agatatattt tataatttat tttcaaatgt
    40981 ttttaataaa atgggaacaa accttatgag tgctctgttg tttatttttt taatgcactt
    41041 tatgtggttt tttgggattc atggtagtaa tgtattagat accgtcgcaa aaaatttatt
    41101 tgaaaatagt atggcaatta acataaattt agttaataat aatcaattac caacagaaat
    41161 ttttactaag accttttttg atacaatggt tttattggga ggatgtggct ctttactatg
    41221 tttagtaatt gcaatttttc ttagtgaaaa acgtataaat gtaagaaagt tagctaaaat
    41281 tgcttcaata ccagctcttt ttaatatcaa tgagatgcta gttttcggga taccaattgt
    41341 ttttaactat attatgtttg taccttttgt aattactcct ataatcttaa ccatcacaag
    41401 ttatgtggct atgtctacag gtattgtacc atgtacagtt tcagctgtag aatggacctc
    41461 acctatattt ttaagtggat atatgtctac aggttcaata agaggtagtt tgttgcaagt
    41521 atttaattta tgtgttggtg ttatgattta tattccgttt ataaaaatgt cgcaaaatag
    41581 atatacatat atgtttaaaa ataatataga aaatttaaca aacttattaa aaaggtatga
    41641 attaacaggt gaacagccta atcttctaaa ccataatggt aaaataggtt caatttcaaa
    41701 aatgttggca tcagacttga agtttgctat gaaaagagga gaaatagagc ttttttatca
    41761 accacaagtc aattataatg gaaatgttgt gggagcagag ggattactta gatggaaaca
    41821 ttcaatagga gggttcattt atccaccact agttataatt ttggctaaag aagaagggtt
    41881 cttagatgag cttggagagt atattattaa taaagcatgt attgatttaa agaagagtga
    41941 aaagctattg agaaatcctg ttaagttctc tgtaaatata tctccagacc aacttgatga
    42001 ccctaagtta ccagagcaaa taaaaaatat cattagtagt aatgatataa atcctaatat
    42061 gttaggtata gaaataacag agcaaattgc attatcaggt tcacaaataa ttattgaacg
    42121 tatcaatgcg atacataact tgggaataaa gttaattatg gatgattttg ggatggggca
    42181 tagctctctt atatatcttc aaaataataa ctttgatata gttaaattgg atggttcatt
    42241 agttaaagag atacttacaa ataaaagaag tagtgaaatt ataatgacta ttgtaaatct
    42301 ttcaaaaaat ttagattttg atatagttgt tgagtatgtt gaaaatatag accaaaggga
    42361 taagttatat ggtttaggat gtgaaatata tcaaggatat tattatagca aagcaatacc
    42421 ttttgaagag tttgtagaat atgcaaatca agaaagagag atataatttt ataagagctt
    42481 gtaaattcta gtaatgcata gatttgtaat aaaattaagt ttaggagaaa tatatgaata
    42541 taagtatagt agtagtaggt aaaattaaag aaaaatattt aaaattaggt attgatgagt
    42601 tcaagaaaag gctttctaag tattgtaagt tagaaattat agagttggat gatgaaaaag
    42661 ctccagagaa tttgagtgtt aaggaaatgg aaattataaa agacaaagaa ggaaagaaaa
    42721 ttttagggaa gataaagcat aatagttatg ttatagcctt ggctattgat ggtaagggtt
    42781 tatcctctga agaacttgct aagactatga gtgatttagc agttagaggt aatagtagtc
    42841 tctgttttat aataggaggt tctctagggc tttctgatga ggttttagga agggctgatt
    42901 ataggttatc tttttctagg atgacttttc ctcatcagat gatgagattg atattgttag
    42961 aacagattta tagggcttat aggataaata atggagaacc gtatcataaa taaatgatac
    43021 ggttttttat gatataattg aattataaaa taaaatcaaa atgtaaagta ggtgtagtaa
    43081 tggacagact agatatattt atcgaaaatt atgattttaa agaatatctt gaaaaattac
    43141 ctagagaatt aatagaagaa aattataaag attttgttat agaattttgg aaaaatccta
    43201 gtgtagatat tattaaacta aaatcaaaat atagtataaa aaatgtagta tctataagta
    43261 gtatattaat gcaaaatcct atccaagagt attatgagtt tcttgaagat atttggaaaa
    43321 ataacataaa aatagatgaa ttaattaata agtatttaat tacagcaaca agaatggatc
    43381 aaattaaatt cccattaata tatattgatg aagattcttt ttgtccttat tgtttaggta
    43441 ataaattcaa tattattaat aatattaagc aacaagatat aaaagttgaa tgtgaaaagt
    43501 gtggtgaggc aattagttat tttattcata aggaagaagt agataatata atagaagaag
    43561 aaaaaagaaa aaaagaacta tttataagaa cattggagaa tgtatataat aaaataaaca
    43621 agattaaatg tcatagatgc caatcagatt tatatgtgtg tattaatgat aaaataatgg
    43681 agtataatat taggtgtgat agatgtaatt cacagtatga atcggttgaa attgcacagg
    43741 aacaatatag attatggcaa caaagagctg caatgatggc taacataaaa aataaagaaa
    43801 atgaattgtt gctaaagaca ctatcaatta aggacgaaaa agatattaaa tttaaactcg
    43861 aagatataat tacggagagt gaaagtatag atgtaattag tgatttagta gatatgcaag
    43921 atagaggaga gaatattttc aagcaattat ttaataatta tgttagacta ggaagattag
    43981 acagaaggtt attggtaact gtgtgtaaag attgcaagca aaatgaaaat acttatacat
    44041 gggaaagagg caaagaacat ttaataaata tgagggggat tacatacagt gaagcagttg
    44101 tatatgagtt aatggaaaaa acaaagctat tgccaataag agcaattatt agaagactta
    44161 tggagaaaaa actattgtat tgtgatgaaa ggagcaataa tttacaagta caccctgttt
    44221 tgattgaaaa tttagctaaa ctagaatcaa taaataaatc tcaaaatata aataatcaag
    44281 tagcttatct aatattcaat aagcaaaaat atatatgtta tcattgtggt gaatcaggaa
    44341 gacccttaaa gataggatat ctaacaatag ataaaaatat aaatgattta tcaagtttag
    44401 tgggaatatg tgatagttgc tatgaagata ttactgaaga tgaaattatt atagataata
    44461 ttttttgtgt ggtagatgaa agaaacaatg aattagggga agcttggaaa tttttaatac
    44521 aatatgatag tagttttaga aataatacaa ttgcagaagt agagcatgca agattatatg
    44581 atatgtatga tgaagataat ttaattcgtg cgtatgcaaa tacattgtat aaacaaacga
    44641 aagatgggtt tgctaatgaa aaagtatttt ttgcatatgc aagagcaata ttgaaaaata
    44701 gcaaagggca agtaagtgta ctacaaatag caaaagaaaa atttaaatta gaaaagtggt
    44761 taaatggata aagggataat acatattaaa attataaatt tatataaaac tgtattgcaa
    44821 ttaagcaata cggtttttat atataagata atgatacaat taaccaaaat gtggtagtac
    44881 ataagtgtta tgagatttaa atattagcga ttaaaataat gattaagtaa aattgtaatt
    44941 gatgaggagt attaacgtat tagtttattt ttatatataa ttaaaatata ggagggaaga
    45001 atgtgagtca tagtaaacta tctgatcaca aattaaaaaa ggggaaattt atagcacctt
    45061 ttaatgaatt tatgacacca ttgaatagta atgagtcatg gtgccttggt cgattgccag
    45121 agtatatatg gataggatta ttaataaata aatatggtag aaaaaaaggg atggaaataa
    45181 tttataaaat aattgtaaaa cttcattcaa ttgaatcaga tattgtaaca cctaggttgt
    45241 ctgagatttt atctatggag gatgtaaagc aggatgaatt ctttagttat attctaacta
    45301 ttgttgaaaa ggaagcttta tctccattga cattaatatt tacatatagt aattatccta
    45361 tttttgttaa atattttgca gagccaagta taaaaattga agatagggtt acctatttag
    45421 atgagacttt aagaaaagct atgcatcatc aaagtgaatt tgctacagac ataagattta
    45481 tagttttata ttatttttgt atgtcaggaa aactcgtatt gcaaaaagaa cagattaata
    45541 atttgctgga atatcctaat ttagaacaca ctgatgaaaa aatgagaatg ttacgtccgt
    45601 ttattcgtgc agcagaatta atggttttaa atatggaaaa aaaatctgat tggtatttag
    45661 atattttttg ggggaggatt agtgttatga ctgaatgtaa attatacgca actaaatttg
    45721 aagatgaaac tgctaataca gacttgtata tggaacaatt acatgagatt tttgtttatt
    45781 tatcagattt actatgtaaa gtaaatccat tagacgagaa aatgttagta ttacttggaa
    45841 tagcaatata ttcttataaa cgattacgag aagtagttga gcataaatta tttaattcca
    45901 tttcaggtag aggctcagta agggtattga tagaaaatta tattatgatg aagtatttag
    45961 taaaaataga agctcaacat gaaaatatat ggtcagaata tcaattttat ggaataggtc
    46021 aatataaatt aattgtggct agatatagag aacaagaaca agatttaaaa aatagtcatg
    46081 ttgattataa atatattgaa gctttagtta atgaatttgt aattgaagaa acaatagata
    46141 tggatactaa atattttgat aagcaaaata tacgtagtaa ggctgaaata gttggagaaa
    46201 aagagttata tgggttgtac tatgattatg attccgcata tgaacatggt ttatggggat
    46261 caataagaga aagttcaatg ttaaagtgtg ataatccagc tcatcactat cattgtatac
    46321 cagatgtaga caataatcaa aatttaaaaa gtgtttggca tgattgtgta aacataatgg
    46381 aaaaaacttt acttttctta gatactgtat atggtatacc acaacatttg ctattagagg
    46441 tgataaaaaa tggaaaagaa ttttttacta aataaaataa atagtattca gaaggaatat
    46501 ttagaattat tagtaaagtt aaaagataat atagatacta tagattatat ttatataata
    46561 gatgaaataa atatattttg gtattcatat agagatgtta taaagcttta cttagggaat
    46621 attacacaaa aagacaatgc atatattttt acaggtgcaa catatctaga tgttgatgat
    46681 ttagaacatt atccatttgt tatgatggga gatatacata tagtagatga ttcgctatgt
    46741 aaatattcaa aaacagtact agtattatca aatcaggaat ttgctaaagt attaaaagac
    46801 caaattattt cttgtataga tgataatatc aaaatattgt ctaattattc ttttgcgatg
    46861 ttaatattac caatgaattt actatatggt aatgacatga aaataataca tgaatattca
    46921 aataatatat ttctgaactt tttttcaaga aaagacttaa acttagatac ttactttgaa
    46981 gaatttaact caatcgaaga tatagctcta gcattgaatc caggtataga gagttatatt
    47041 gtttttgacg aaggtgaaga tttaactaaa aatctggaag aaagatttaa aagctttatt
    47101 gataagggga aggtacccct accagcacat aaaagtgatg cttttaaatt ttggctgata
    47161 atttatggat ttataactca ggcattagat attatattgt catgtaaagg atttaaccta
    47221 actccttatt taagatatag agttacatta caatatgttt tattactagg cgataatgtt
    47281 tttgatattg aagatctcag caatatgttg ttaaaatgta aagtagctca tgtactttat
    47341 gcaatatttg ataaaagcga aataaaaaat atttcctttg ttcaatttta taagaaatta
    47401 agtgaatata aatttagcta taaagtagaa aatgatatca aagaaaatat aaatataaat
    47461 caaattgctg aaattttaaa taaaaatatt acattgtttt taaattatat ataaatttat
    47521 ttatataatt acattcctta gggtacataa cagaaaaaag gctgtcgcac taaaaaatag
    47581 tgctacgccc ttttttatac aaaaaaataa agctcaagtt caaaagaacc tgggattcct
    47641 gtataataat tgtatgctaa aacaaaatac tatacaaatt gattatacta cttatggtaa
    47701 taattatcaa tttaaattac cactaaatat tgattatatg attccaaaag atgctatatt
    47761 tgttgatggt acaaaaatag agtcatctgc caatagatat acttttgttt ggaaaaaaac
    47821 tataaacaaa aatatggtta gagtgatgaa tgatatatct aatttcatat taaaatgtgg
    47881 gattgatttt ggtattaaaa taatttatag aaataaaatc aaaatatatc atttaaaaaa
    47941 acttttaaag aagcttaaaa aaatatcaaa agaatcaaat ataacatttg ttcatggaaa
    48001 aggaaagaaa aaatctattg ttcaaaaatc tatagcgaaa ttaaataatt atatcgatag
    48061 attgaaaaaa tatactaaag accttcatat aatgggtgaa ctaaatagtt attctaaaac
    48121 agataatgac gcaactttca tgagaatgaa gaaagaccat atgaaaaatg ggcaattgaa
    48181 accagcatat aatatacagt ttggcgtaga ttcagaatac atagtttggg taagttcaga
    48241 gcataaacct actgatacta caacatcaat accattttta aaatctattg aagagcatac
    48301 aaaatttaaa tatcctaaaa tagtagctga ttctgggtat gaaagtgagg aaaactatac
    48361 atttttagag tgtaataatc aattatcttt tataaagcct gcaaattatg aaattagtaa
    48421 aactagaaaa tataaaaatg atattgggcg tattgataat atggattatg atgaaaaaaa
    48481 agattattat atttgtaaaa atggcaaaaa actatttgct aataaaataa tcaatagaaa
    48541 atcaaaaaca ggatataaaa gtaaaataac ttgttatact tgtaaagaat gctgtgattg
    48601 tcaatataaa aacggttgta ttaagggaaa taatagtaag attcctcttg aaaatagaac
    48661 taaaaattta caagtatcta agttatttca tgaaaaaaga aaagaaaatt taaagagaat
    48721 tataagccaa gaaggttgtc aacttagaat gaatagaatt atacaagcag aaggaacttt
    48781 cgctcaagta aaacaaaata tgaaatttag aagattttta agctgaggca aagaaaatgt
    48841 tatatcagaa tgtattattg tagcgatagc tcataacatt tctagactac acaacaaaat
    48901 aataaaaaat aaatgtggaa tatatcttca tcatttaaaa gaagtattct aaatttatta
    48961 tttatagtta gatattatct gaaaaaatgg tatttttata cctttatttg ttatgcataa
    49021 ttttacttag aacataagct ttatataaaa caattaaaaa tatatctaat taagataagt
    49081 aaaaaaagct atcacagaac aaatttaatt tgctaatgcg acagcccatt tttgttaatt
    49141 tgacacttaa taatattaaa ataacaaaaa agtattgaaa gtatattgca tttaaggtag
    49201 aattaaataa aatattataa cattataatg tttatatagt tgttaataaa aatttggagg
    49261 aaaatatatg ataaaaataa tgttggcctg ttcagcaggg atgtctacaa gtttattagt
    49321 tactaaaatg gaaagtgcag ctaaagaaaa tggtatagag tcgcaaattt gggcaatacc
    49381 agaatcaact atacaaaatg aaatagaaaa atgtgatgta ttattactag gaccacaagt
    49441 tagatatgta ttacctaagg ctcaagaaat tgctaggcca tataatatac cagtagaagt
    49501 tataaatatg atgcactatg gaacagttaa tggagaagct gttttaaata gagcgataga
    49561 acttaacaac actaagtaat ataaattata atgtattttt aatatataaa ttgggagaat
    49621 caaaggatgg atgaaaagat tatagaaata tcttttaata taataggtta tgcaggtgaa
    49681 ggtaaaggat tagcttttga agcaataaaa gaggctaaga atggaaatat agaaaaagca
    49741 aaagaattat taaaagagtc tagggaagtt ataaataaag cacatagata tcaaacagaa
    49801 ttaatacaaa acgaagctag tggaaacagg actgaaataa gtgtcatact tatacatgca
    49861 caggaccact taatgaatgg catgaatttt caacagttag ctgaggaaat cgttgattta
    49921 catttgaaat tacaagataa ataaaaatta aagataataa attaagagag ttcttaaaag
    49981 atacattatg tgtagcacac taattgttag attattgatt caatatttag tgagtaatac
    50041 attaggatta ttttgaggac tctttttata tttagtttaa agttaataaa tatttattat
    50101 taataatata agattatatg ttataatatt ataacatata atttaagagg tgaatcatgt
    50161 taagaaatca accattatat atacaagttg tagatatatt aaagcaaaaa atattaaata
    50221 acgaatataa aattgatgaa aatattccaa cagaaaggga gttagagcaa gagtttggag
    50281 tcagtaaaat tactattaga aaagctattg agatattaga atcagaaggg tatgtagaga
    50341 aaaaaagtgg aaaagggaca aaagtaataa gtaatagtct ttttaataag ctatcaaaag
    50401 cagagtcttt ttcaagtata cttttatcta aaggtcataa gttatctaaa aagactattt
    50461 caattgaaaa aataataaat gatacaaatt cacaagtatt tagtatattt ggagaaaaat
    50521 gtagcaagat tactagaatg tattacttag atagtaagcc atatatattt tttactcatt
    50581 atattccttt tgatgaaaat ttaactgttg aaagttttaa taatgaaagt tctttatata
    50641 tgtacttata taggagaaat ataaatataa ctagatttga agatgaattt tttatagaag
    50701 aatcagaact agaggtatca aaggctctaa atctagctaa agacatatta ttaggaagaa
    50761 aaagaaagac ctatgatgag aatgataata tagttgagct atcatttgca agatataata
    50821 cagaagtaca aaactatgta attaaatacg aaatataata agaatcctga gtttattgaa
    50881 atgataatat gctcaggatt tttgtttagt tgtaaaaaca aaaaaatatt ataacattat
    50941 aatgtttaca accaaacatt ataatgttat aatattttta ataaataagt gatattatca
    51001 attacataaa aattagttta tgttatgaaa tcgttattgc attataaata aatgataata
    51061 tcaataatac agggggataa ctatggaaaa attcgcaagt tttttagagc gcaagattat
    51121 gcctgtagca gcgaagataa gtaatcagag acatatgaga gctgtaagag caggtataat
    51181 agcaacatta ccactaacaa tagtggggtc atttttcaca atattattaa acatacctat
    51241 tgatgcttat atggatttta tagctccatt taaagcaata ttagatatac catttagata
    51301 tactgtagga tttttatctc tatatgctac ttttgggata gcatcatcac ttgctaaaag
    51361 ctacgattta gatacaacag gtgtcggtat gcttgcagtt atggcatttt tagtttctac
    51421 aatagttcca actcaagtag ttgaaccagt aggtggagtt atagaagctg gtagatggat
    51481 ggatatggca aaacttaatt cgccatcatt atttggagct atcgtaacat cgttaattac
    51541 agttgaaata tatcgtttta tgaaggaaaa gaatattaca attaagatgc cagcaggagt
    51601 tccagtagag gtttcaaatt catttactgc attattaccg acagcagtaa ttttaatgtt
    51661 attctgggta ataagacata ttttaggatt tgatataagt gttgcactaa gcgctatgtt
    51721 atcaccttta aaaggattct tatcaggaaa tagtttaggt ggtgggttac tgacagtatt
    51781 cctaataact ttattctggg tacttggaat acatggtcca gctataatgg ggccagtaat
    51841 aagacctata tgggacatgt ctatagcaga aaatataact gcattcacag aaggagtatc
    51901 agctcatgca atgccaaaca tatttacaga acaattttta cagtggtatg tatggatagg
    51961 gggagcaggg gctactcttg cattagttgt aatgtttatg ttttctaagt cacaatatct
    52021 aaaaagttta ggtagattag gatttttacc agggttattc aacataaatg aacctataat
    52081 atttggagca ccaatagtta tgaatccaat actagggata ccatttataa ttggacctat
    52141 aataatgaca attctatcat atgttcttac tattacaggg gttataccta tgatggtagc
    52201 aagattacca tttgcaatgc cagcaccaat agcagcagta atgagtacta actggagtat
    52261 actagcaggt atcttagtat taatcaactt tgtgatatca tttgctgttt attatccatt
    52321 cttcaaagtt tttgaaaaac aacaattaca aagagaacaa gaagaaatga gtgaaaattt
    52381 ataaaaatac atagatatag aggttttgta ctatataaaa tatagaaaaa gcttataagt
    52441 tattaagggt gaaggtagga ggaatgacct ttgcctttaa ttttatatat tttaaataat
    52501 gtaatttgag gaggagaaag atggaaagaa gattaggaat atcagtatat ccagagcata
    52561 gtaacatgga agatgataag gcatatataa aaatggcttc aaaatacgga tttaaaagaa
    52621 tatttatgtg catgctttca attacaagac ctaaggaaga agttaaaaaa cattttaaag
    52681 aaattataac ctatgcaaga gaattaggat ttgaagtaat ccttgatata gctccaaaca
    52741 tatttgatat attacaaata tcttatgatg atttaacatt ttttagtgag ttaaatgcta
    52801 gtggaataag gcttgactat ggatatgatg gaagtaaaga agctatgatt tctttcaatc
    52861 catatgattt aaaagtggaa ctaaatatga gtaatgatgt agcatacttg gataatataa
    52921 ttacttacaa gccaaatgta aataatatat atggttgtca caatttttat cctcaaaggg
    52981 gtacaggctt gccatatgat ttttttgtaa gatgttcaaa tagatttaaa aagtatggaa
    53041 taagaactgc tgcttttgtt aattcaaaat acgcaacaat agggccttgg aatataaatg
    53101 atgggctgtg tacgcttgaa atgcatagaa acttagatat tgctacagca actaagcact
    53161 tattcgcaac aggattgatt gatgatgtaa ttgtagggaa tgcatatgca agtgaagatg
    53221 aattaaaaag aatgtctgaa gtaaatgaat accaagttgt atttaatgta gtagctgaag
    53281 aaaaaacttc tgaagtagaa aagataataa tggtaaatga gcaacacttt agaagaggag
    53341 atataactaa tcaggtagca agatctacag aagtaagaaa aaaatatgct aaagaaaatt
    53401 tccctaaaca tgataataag aacctcttta aaagaggaga tgtagtgatt ggtaataatg
    53461 actttggaaa gtataaaggg gaattacagt tgatacttca agattgtaca gatgaaagaa
    53521 aaaataaggt gggtagaata aaggaagacg aaataatact tttagacttt attgaacctt
    53581 ggagtaaatt taagattatt ttagagggag agtaaagtga agatagacat attaataaaa
    53641 tgtggaaaaa cagtagataa aagtataatt gatatagcta tattagacga taaaataata
    53701 gaagtaaaaa atcagataga tgattctaag tatcaggcaa aacaaattat aaacttagat
    53761 ggagagaaat ttattagtgc tggttggata gatatacata cgcattgcta cgaaagacta
    53821 gacctttata aggattatcc agatgaggtt ggaataaaaa gtggagttac tactgtagta
    53881 gatgcaggaa caacaggagc tttagatata ggtaaatttt atgaagatac taaaaaatat
    53941 aaaacaaatg tatatgcttt aataaatatt gctaagcagg gaataacatc tcaagatgaa
    54001 ctttcaagta tgatgaatat tgatgaatat gaacttaaaa gagcagttaa aaaatacaaa
    54061 gattttgttg ttggaatcaa agctagaatg agtaaaagtg ttgtaatttc aaatgatgtt
    54121 gaacctttaa aagtagctaa aagaataaaa aatgaactta atctacctat gatggttcac
    54181 tttgggagtt ctcctccaac gatagaggat atatttgact atatggaaaa aggagatata
    54241 ttaacccata tatataatgg aaagccaaat ggaatactta gaggcaatga ggttaaaaaa
    54301 gaaatcatag aagctagaga aagaggtata atccttgatg taggtcatgg aaccgaaagt
    54361 tttagtatgg atattgcaat gaaatctaag gatgcaggaa tttttccaga cactataagt
    54421 acagatatat atattaaaaa tagaataaat ggtccagtgt ataatctatc tacaacaatg
    54481 gaaaagttta tatatatggg ctattcactt gaagatataa taaataaagt tactaaaaat
    54541 gcagcagatg caataagttt aaaaaataaa ggtttaataa aagaaggata tgatgctgat
    54601 ttaactatat ttgatgtggt taatgaagaa aaagaacttc aagattcttt gaataagtca
    54661 gtaatcacaa gtacgtctat aaagccaaga gcagtagtag tcaatggaga atatttaaat
    54721 ataggtaagt ctatagaaga gaatgagtag aagggagaaa ctattgtatg agtagtatat
    54781 ttgaaaaata ctctgtaaga cgtgttataa atgcttcagg caaaatgact atactaggag
    54841 tatcaacagt agataaggaa gttattgaag caataggtga agggtgtaaa aatttcttta
    54901 taatagaaga acttataaat aaaacaggtg aatatatagc aaatttatta gggtgtgaaa
    54961 gtgcactaat agtttctagt gcatctgctg ggattgcaca gagtgtggga gcaatgatag
    55021 caaaagatga tatgagtcta gtttacaatg taaataatcc taagaaacaa gttaaaaggg
    55081 aaataataat tccaaaggga cataatgttg attatggagt tccagtagaa gtaatgataa
    55141 gacttggagg aggagaagtt gttgaggccg gttatgctaa tatgtgtaac aaggaacata
    55201 taataagaga gataaatgaa aatacagcag caattatgta tattaaatct catcattgtg
    55261 ttcaaaagag tatgctaagt gtattagatg tagtacaagt tgctaaagaa tataatttac
    55321 ctttgatagt agatgcagca gcagaagaag atttaaatgt atattatgaa ttgggagcag
    55381 acctagtgat atacagtggt gctaaggcta tagagggtcc tagctcaggg ttagtaatag
    55441 gtaagaaaaa atacatagat aatgtaaagc ttcaatcaaa gggtatagga agagctatga
    55501 aaataggaaa agaaaatatt gtaggtctaa catgtgcaat tgagagatat ataagtaatg
    55561 ataaagtaac tttaaaagaa atggaggaca agctaaatcc atttatagac aagataaata
    55621 ctataaaggg agtgagtgct agtataacta gggattcagc aggtagagaa atacttcgtg
    55681 gagaaattga ctttaatgaa gatataataa ataagtcaac acaacaaatt ataaatgaac
    55741 ttagaagtgg agagatagct atatacacta gagactataa ggctaatgaa ggcaagattg
    55801 agattgatat aagaagtgta actggaagtg atttagatac tatttataat aggataaaaa
    55861 atatagtaga aagttagagt gtagagtaag tgacattata atgatttaat aaattaaatt
    55921 ttaccaatgg aggggataaa tatgaattgt ataccacaat attataaaaa tagagtttgt
    55981 ttaaatgttc ttgcaggaag cataaaaaat gctaaagaag tatatgatgc ttgtgacggg
    56041 catgtattga taggagtact atcaaagaat tacagtactg tagaagcagc tattgaagat
    56101 atgaaaaaat actcaaagga aatagataat gcaatatctg tggggcttgg agctggagac
    56161 ccaaatcagt caaatatggt atctcagatt tctaaagaac ttcagccaca acatataaat
    56221 caagtgttta caggtgtggc tacgtctaga gcattacttg gtcaaaatga tagtataata
    56281 aatggattag tttctccaac tggtaaacca ggatttgtaa aaatatccac aggtccatta
    56341 agttcaaaag aaaaagatgg tatagttcct atagaaacag caatagctat gatgaaagat
    56401 atgggaggaa gctcaattaa gttttttcca atgggaggac ttaaaacaaa ggatgaatat
    56461 atagaagttg caaaagcttg tgcaaagcat aatttttatt tagaaccaac aggaggtata
    56521 gacttagata acttcaaaga gatagttcaa attgcacttg atgctggtgt agaaaaagtt
    56581 atacctcatg tttatacatc aataattgat aaagaaacag gtgaaacgaa agtggaagat
    56641 ataggagtac tttataaaat aatgaaagaa ttattgggat agatttatga atatattagc
    56701 ttttggtgaa ataatgatga gactttcagt acctgactac aagttcttaa cacaaaccaa
    56761 tgaactaaat tatataatta caggcacggg attaaatata ttatctggac ttaaaaactt
    56821 tggatacaat acctatatgt tgacaaagtt gcctaataat aatgtaggta aagcattaag
    56881 tgcaaatata agaaagcttg gagtaaaaga tgactttatc acatatggag ggaatcatat
    56941 aggagtgtat tttcttgaaa atgggtatgg agaaagacct tctgaagtga cttatttgaa
    57001 taggttaaat agttcatttt gtgagagtaa attacaagat tatgatattg ataaatgttt
    57061 agaaggaatg gatatagtcc atatttgtgg tattgctatg caacttacag attcagttaa
    57121 agagattgct ttagaactag ctagaaaatc ttatgaaaag gggataaaag tattctttga
    57181 ttttaatttt agacaatcat taaatccaga aaggacttat gatgatttag taaatgatta
    57241 taagaaaata ctaccatatt gtcatgggct gtttgctagt tatagagata taaataagat
    57301 acttaatata gatagtctaa atataaaatc tagttcagaa ttgattaaaa aagagtatga
    57361 tataggtatt gtagctggaa ctatgagaag atttgatgat atgaataata gatttataaa
    57421 gggatatata tcaaatgatg atggttattt tgaaagtagg gagtataagt tagaaatata
    57481 tgacagggtt ggtgccggag atggatatgt agcaggaatt atatattcat atttggaaaa
    57541 tatgaagagt gaagatatag ttgagtttgg ggttgctagt tcggtgttag ctcatacaac
    57601 ttatggggat aattctttag taagcacagg tcatgtactt agactgatga acaatgaaaa
    57661 aatagatata ttgagataat acatttgtat ataataaaat ttttatcttt tttagacaca
    57721 tttttgactt gcttatattt gttaaacaga gttattttta atgattataa atattaaatt
    57781 aaaagttaaa taataaaata gtagaaaata gcattaacta tagaaaaaat ggttaatgct
    57841 atttttatcg ttaatattga ttaattttat attatagaaa tgaacttttc taatgctgga
    57901 tttgtatttt ttttattcca tacaactaca acttcaattc tattttctac ttcttttata
    57961 ggtactattg caatatcacg ttctatcatt gtatctgtaa cacaaaatga aggtaaaatg
    58021 gatattccca tgttagaaga taccaatgat tcaatagtat taagattatt tgaacgttgt
    58081 accacattag gtacaaaccc tgcttcacga tatctatttt gtatcataga tttttgtcca
    58141 tactcatccc ctgtttcctt tacaaaaata aatttatcat gttgtaattc aattaaatcg
    58201 atagaatcct cattgtaaag tggatgacca ggaggtaaaa gagctaccaa agaatatctt
    58261 tctacagttt tatattcaaa atcttttaat ggttgatttt ctggattaat aacaaaagcg
    58321 aggtccatag aattattttt tactaagttt aaaagttcgg ttatttcatt agtacaaata
    58381 tccatagata tattagggta tgtattagaa aattctttta aatattgttg aagtttgttt
    58441 ttttcatatc ctattaaggt tccaatgctc aaagttccaa aaaaaccatg tgcaaattgt
    58501 tgtgtttttg caatagcatc attgatattt tttattatag tacgtgcctc agataaaaaa
    58561 acttttccag ctggtgttag ttcaacatga cgtttacttc ttgtaaatag agttacattt
    58621 atttgttctt ctaaagcttt tatttgctgt gtaacagcag tttgagaaat ataaaatttt
    58681 tctgctgttt tggtaaaact tagcttttct gctacagata taaaatattc taattgttta
    58741 gtattcaaat aatcacccct atttaaactt gattgtttgt aaaccttatt tatctataat
    58801 taaagcttat tatagtataa gaaaatttac ttttaaagaa tattagaaaa tatttgtata
    58861 aaaatatatg ttttaagtat atctttacat tagattttat aaatttatta ataagaataa
    58921 cttatatatt ccaatgaaaa cgatattgga tttaagtaag tttgtctcat aaaatgaaag
    58981 tatatcaatt gataatactt taaaataaga agggagaaaa aatggaagat aaattttatg
    59041 caaaaggcaa cggaaataac ggatatatta aaaatcttga agtttgttcc tttaataact
    59101 tagatggaac ttgtggaatg tttcaaatgg ctctgtacaa aagagatgaa aaatactatt
    59161 tatatggatg ctgttttgga ggaaataaaa aaaatggagt aatgattagc gatattacag
    59221 acccttataa tccacaattt ataaaacatt ttcaaatgtt agaccctaaa gagtatccta
    59281 caacaacaac tcccaaaatt caaatagcag atgatttaat gatagtagca atgagttgtg
    59341 gaagtggacc aggagcactt gttgaccaag ctaaattagc aaatattaag tgtgaagcag
    59401 gaattagaat atacagttta aaagaagacc ctttaaatcc taagttttta ggatattggg
    59461 attgtggctt aaagcatgta atgggtgttc atagattcat gtacaatggt ggaagatatg
    59521 tacatttatc aagtgattgt gttggctttg aaggtctgat ttatagggtc atagatataa
    59581 taaatcctac taatccagtg gaaataggta aatggtggag accagaccaa tatgcagatg
    59641 gatatccaaa tagaactttt gatgcaggag cacctcattg cccagaattt atggataaag
    59701 gatggcttca tggacctcca tttgtaagag acggaaaagc atattgtggt tatggaggag
    59761 ctggtttagt tgtattagat gttgaagatt taacaagacc aagatgctta ggtgaattgc
    59821 catttacgcc tgcattttct agtagacttg caggtgcaag aactcataca gcattaccat
    59881 tgccaggaag agatttagtc gttgttcaaa atgagggaga aagattccag ttctttaaac
    59941 cagataacat tacagatgtt caagctatga ataatataca tatggttgat gttagtgacc
    60001 caacaaaacc aacattaatt gctcaatttc catatcctga agttccaaaa gatttccctt
    60061 atcctaactt taatgttgca ggattaggaa aaccagggcc atttggtcca cataatcttc
    60121 atgaaccaat ggataataag ccatggttag agcaaagagg agatagagta tattgctgtt
    60181 atttccatgc agggctaagg gtttatgatg tatcagaccc atattatatc aaagagctag
    60241 catattttat accaccaaat ccaaataaaa caccagaaga atcttatttc ccaggattcc
    60301 caggaccacg cttggcagta acagaagatc ttatcgttga tgatagaggc tacatcatca
    60361 tagatgcttt agatgatgga ttctatatat taaaaatgaa agaagattaa ataaatacta
    60421 aagagggaga gttgaaaatg aaaatactag gtatttcttt tggaacaaaa aatggaaata
    60481 atgacacaat gtgtaaagtt gcacttaaag gtgccaaaga agcaggggct gaagtagaat
    60541 ttattcaaat gtcatctatt aacattaaac attgtactgg atgttgtgcg tgtgttaaaa
    60601 ctttattatc tgggaaaggt agtatgtgtg tattaaaaga tgattttgaa tggttgcttg
    60661 acaaaatgaa agatgcagat ggtatagtag tttcagaccc tatttttgaa gaaggggcat
    60721 caggattatt ccatactata atggaccgtt ttggacccag agcagataga ggaaataaca
    60781 ttataggaac aaaagttgca gaagttatag gaggaaaaat tccagattca agaatgctta
    60841 atgataaagt aatatcattt atgggaatag gaggttctga ctggggtaca agagttcaat
    60901 gtgaacatgc tatgctagct ctcataccaa tgtggaaagt tatagataat gcttggttcc
    60961 catgggcaaa ggaattagta atggatgata caaggcttgt tcaagttcat caaattggtt
    61021 taaatatagt tgaagcagca aaagattttg aaaaagcttc atatcaagga gaagaaggtg
    61081 tatgtccaca ttgccacaat agattattct accttgagcc aggtactaaa aaggcaattt
    61141 gtgctctatg tggtatagtt ggagagttag atactataag tggaaaaact atatttagtt
    61201 ttccagaaga gcaattaggt catgctcatg atactttacc aggtaagttt atacatggtg
    61261 atgatattaa gaaaatggaa ggtcattatg cagaagttcg taaaacacaa gaatttaaag
    61321 aaagaaaaac atcttataat tttatagagc cattaactaa agaaaagcaa gctggagttt
    61381 cattaggata ataattaaaa tactaagact cttttttaag ggatgttaga tgttatagga
    61441 ggcttattgt atgaatgaaa agccaagttt taaacaaatt gaagttattt tagcagttat
    61501 ttttttggta cttacatatt acaaggttag attaactcca gcatttattg ttatatttat
    61561 accactatat ttaagttatt ttgcagtatc tatgattgta aatcaaatag caattaagct
    61621 attggagata aggcaagcta gggaagctac taattacaat ataggaaatg gatagaaaga
    61681 aaaaagaaat attaacactg tctatgggga ttgctttact acctccttta tgggcagtat
    61741 tagcacctta tataggaata aaaactggag ctgtagcact aatctgtgca ggattatatg
    61801 taactaatgg taataaacaa aaagatggat taaaaataat gtttggtttt tggtgtggag
    61861 atttatgggc agtgttagcc attttaatta tgggatatat gaatttcaat caaaacctag
    61921 aattattttt aacacttagc atattaggtt tttttgcagt tgtaattgca tccttatttg
    61981 aaaaaataat tttcctacca tcatggcttt gtggttgggc tataggtcta actgttatga
    62041 caggtgaaaa tattattaat ttacaagata tttgtattca aattgctgta gctatggcag
    62101 taggagtatg gtacgtgggt gcaggtgtag atttgtttac aatatatatt ttgagtaaag
    62161 ataggaaaaa gggaaattga aagcatgtga atatactttg attataggag aatggctatg
    62221 ggttttgaat ttaaaataat gagaagttta atatatgtag gacttgccaa ggaagaatat
    62281 agacctaagc taatggactg gttatatcgt caccatattc cagatagtat tagcactttt
    62341 ggaccatatt gtactaaata tgccttttat caagcatatc ctacaccaaa tgaaggtgag
    62401 cgttttggtg cacgtaagat gcaactaaca gaacattatt ggcttgtaga tgaacatatg
    62461 cctgagatgg caaatagaat tatgacagaa tatatgccta tggatgttct acgttggcaa
    62521 gggtgtatac cagatgtaga aaataaaagg gttcatgaaa atgtagaaag tggagatgca
    62581 ggacgtgcag taggtggaga taatggatgt ccaccattta tatttgcctt tgttccaata
    62641 aactgggaag aagactttag aggaaaagga cgtactgtac aagatggacc aaactatcgt
    62701 tggcaattta tgattaagta tccagatggt atctctaaag aagaaggaga aaaatggttc
    62761 tatgatgagg tagtgccata ctttacaaac tgttgctatg ttaatcgttt tgtcagtagt
    62821 aaaataatga ttaattatgg agcaactgct tttgaccgtg tatcagaact atggtttgaa
    62881 ggggaagaag aatggtataa agctgtggtt gaagagacaa agtcgtttat taaaaaacca
    62941 gaatgggcac aagaagagga gttcccatat ttaaaaccac aattcaatat cgcatcagta
    63001 ttcttaggtg atatagcaac tatggatgca tactcacagt atcgtggata tataccaatg
    63061 agataaaaat tatagtttgt gataagtaga ggaggcattt actcttactg gtagaagaag
    63121 acttattgta tccttaaaag taggtgaata tatagtttta tatttaaatt tatataaaac
    63181 taagactaat aaatatgaaa caatagaatt agaataattt gataatattt gttaaaagag
    63241 catttagaat gtgtttaaag attaagatat tccttttatg gtagcagata gttgaaataa
    63301 taaaactgtt atcatgaaag gaatattttt atgtatagga aatttttaaa aataaaagtt
    63361 aaatatgttt aagaacatct taaagtgaaa gaatcattgt tagaaatatg tagacaatat
    63421 agtctttata acgtatcata ttaacaagtt tacacttgga ttatgaaata aaaagagtaa
    63481 ttccaaaggt tgtaaatact atgctgactt tgatacttca aagtttaggt gattttgtaa
    63541 ttgttaatag aaatacgttt aatgagcata aagaatttat ctaataatag gagaatataa
    63601 tgtatacaat tggacaagta tctaaatttt taggaatatc tagagataca ctaaaatttt
    63661 atgaggacaa aggattagta aatcctaaga aaaatgatga aaatggatat agaatatata
    63721 atcaggttga tatctatgat attgcaacaa taaactttta tagagaaatt gatatagaaa
    63781 ttaaaaagat tcaagaaata agaaaaagta agagtataaa caatttagaa ctcttactag
    63841 aagagaagga acaaatcata ctaaaagaga tagaatataa aaagcttctc ttaaaaaagg
    63901 ttcagttagt caaagaagat tgtgacaaaa taaaaacata ttttggaaaa tacacaataa
    63961 aagaaatgaa gcctttggaa gtaaaaggta aaataaaaca tgttactaac tatgaggaat
    64021 atgaagccct aaaagagaat acaaacaact taaaaaaagc agttacatta actgatttaa
    64081 gaagagtaat aaattttaat gaagaaggta taatagaaga aaaatttata attgtaaggg
    64141 aagtagatga ctacaacaaa atcatagaag gtgaagttct atctcatccc aattgtattt
    64201 atactattat tgaagatggc agatggtcaa ctggaggaga aaatattgat aataaagtgg
    64261 aagacagatt aagagaaata gcaatagaaa atgaatgtga attacttgga atagtctatg
    64321 ttaatatatt gcttactact tatgaagaag ggattgagcg tatattttta gagatttatg
    64381 cacctataaa ataatataaa agcattgacc tgggacttac tcataggttt aaactcatga
    64441 tataagcagt tataacttat atagcaatta aatattaatt tgaaatgagg attacttatg
    64501 agaacagaga aatcattaaa aaggcctata gccagtttta ttattctaac aaatataatt
    64561 tttttaccac tttttttatt ggtagtagtg actataatgt taaaacttcc aacagtgata
    64621 tctgacattg cgttgtgtat atcagcgtgg tcatccactt ttgcatttat gatattattt
    64681 aaaaaaattt atccagataa gaaattttta gtacacgtaa aagatagatt tagaaataaa
    64741 cttaaatttt caacagtatc tataataatt agtatacaag tcctaatagc tgtagtagtt
    64801 atatttatat tagcatctaa aaatcatgga ataatgccta actttacagt ttcatcatgg
    64861 ggagcattta tatatttatt tttaaaaaat ttatttgcag gatcattagg tgaggaatta
    64921 ggttggagag gatttgttca aaatcatctt cagaaaagac attctccttt aaaagcatcc
    64981 ataatagtag gtttttggtg ggggatgtgg catttaccaa tatggtttac aacaggattc
    65041 aaaggacttg atttaataaa atatattata ttttttatga ttgcaattat atcaatcagt
    65101 attataatga caacttttta taatctaaat aaaactttga taatacctat tgtaatacat
    65161 caactattta attttttaat agggataatt aatggagatt taatagagct tataaattac
    65221 tatgcaatgt tatatttaat agttgcaatt gtattggtag ctataaatcc aggaaatgcc
    65281 ttatataaaa gattttctaa aaacacaaca caaatacttt aataatataa gtgagaatca
    65341 tatcacaaat gagagaaata attctcctta ttaattaatt ttaattaata aatattacaa
    65401 tagatttatc tggaatggaa ggtatgcaga gtgtatttca ttagatgaaa cacttaaaag
    65461 aatgaaatag ataagtatca acttattata tgagagaaac tttaactttc ttggtttaaa
    65521 atattaaaat tataaggaac atttattatt aaatacttta tttatatgaa ttaattgaag
    65581 aaaaaggata ttaaactaca agttaaaaaa taaatttaat atattagaat tataaataag
    65641 gcacattaat tttattttaa attaatgtgc cttttattta tggtaattta tgcataatta
    65701 gtatcgtttt gattctttaa ataaattttt cttggtttct tcacataagg aacttttttt
    65761 aatttataaa atctacagtt atattatagt atctatttta gagaagttta atttttgtat
    65821 caatctaaaa caaaagttat acttaaatga aattgaaaac gataaaattc tcaaataaaa
    65881 taagtattgt ggaggtgatg aaagaatcca atgataatat gaagactaat cttaataaga
    65941 aagtaggggt taatggtagt ggacaaagaa attgtatcaa ttctccagat tttattaaat
    66001 agcacattga ttacaactaa tggattacaa gaggagtcta attcatcaaa gagacaaatt
    66061 acttatagaa taaataaaat caatgacatg cttaaagtaa aaaatgtacc acttatatgt
    66121 ttaagagctg ataaagatat tatcgttaga aaagaaacaa aaaaagcaat taaagaaatt
    66181 ttagaaaaaa actattctaa gaatacttat tattttagta agacagaaag acttttatat
    66241 atgtatttaa tgctttttat taacatggag gatatttcaa ttaatcattt tataaattct
    66301 ataaaagtaa gtaggtctac tgtaaatctt gatttcaagg atttgatacc aaagcttgaa
    66361 aagaagaaca ttaaagttaa gaacaatcgt ataaatggat attacatagt tggcaatgag
    66421 atggaaatta ggagagtgct tattaaaaat attatagaaa ctttgtctaa tgagaaaagt
    66481 tcaagggtat ttgatatttt tattaaagaa tataatttag atagttttga agaggctaaa
    66541 aaaattatat taaagctaat aaaaaaatat gaaattactt ttgttgaaga tagattaata
    66601 gaatttatat atatatttat ctttctaaag gcaaggatgt attcaactag aatagttact
    66661 caggaaaatg tagatattcc taatatttca gttatgagtt caatgaagga gtataaattt
    66721 gctaaggaat tattagaagt atatgggagt gaagataaaa taaagcctca caatataatg
    66781 tatattagtg cttggatttt aggtatatca gtaggaaatt atgaagaaga tacagaagat
    66841 aaggatgtaa tttcaaaaat tgtaaataaa atgatgacaa agtttggata tttaagtgga
    66901 gtttactata taagccaaga aaaaatattt aaacaattat attctcattt tagacctgcc
    66961 tactatagac ttttatttaa attacctatc tataatccga tttgtgaaaa agtaaaagaa
    67021 gaatataaat tagtttatag aattgtaagt aatgcaatga aagagttttg cggattattt
    67081 ggagaagaaa ttcaggaaga agagttagca tatcttacaa tgcactttgc aacacttttt
    67141 tcaaataaaa aagaatttga tggttttaga aaaagaatag cattaatagt ttgttcaaat
    67201 ggcgttggta gttcagctat tttacatgca gaacttacaa acttatttcc tgacttacac
    67261 tttataccaa tgtcggaatc agttggatta gaaaatataa gtgaacctgt agatattgta
    67321 tttactacta attataacgc agagggttta aaaacagatg taccagtaat taaagtaagc
    67381 cctgttatga ccacaaaaga aaaatataag attacacgtg aagtgtatat tcaattaggt
    67441 gatatttttt taagacaacc taaaatagat gaggttatgg atataataaa aaaatatgca
    67501 aatgtaacct ctgaaagtat tctttcaagt gagctattag cttattttac acagatagag
    67561 aattttacat ctaaggaagg agaggggcct atgctaagtg agattactaa tgaaacacta
    67621 gtaaaaataa aggtaaaagc taagaattgg gaggaagcta ttagacagtc agcttctgta
    67681 ttagttgaaa ataacaaagt aactgaaggg tatgtagatg ctatgattaa ctcagcaaaa
    67741 gcatctggac catacatagt aattacaaaa catgttgcac ttccacatgc tagaccagaa
    67801 gctgggtcaa aagagattgc aataggcatt gctactttag atagtcctat tgagtttggg
    67861 aataacgaaa acgaccctgt aaaatatgta ttttgtctaa gtgcaataga caataatagc
    67921 catttacgtg ctatgtctga gctagttgaa ctattggaag aagatgagtt ttttaaggtt
    67981 ttagatagtg ctaaagaagc taaagaaatt attgatttta taaaaacaca cgaattataa
    68041 aggaggattt aattatgtat aaaattttaa tcgcatgtag agcaggagtt ggctcaagtt
    68101 taatgttaaa aataaagact caacaaatta ttaaggaaaa taactttcca attgaagtag
    68161 aacatggttc attagattca ctaaatggat tcaatggaga tgctgtagaa acattaattg
    68221 atgttgctga agaattaaaa aataaaaatt tgaagtttga tataattggg attcacaata
    68281 ttgttgaccg taatgaaata aagacagcac tagaaaaatt ccttgcttca aaagagggat
    68341 aaatttaaga tgataaggag gaatatttat ggagtttatt attagtttgc tgagtacacc
    68401 tgctgttttg cttggcgtag ttgcatgtat aggattgatt cttcaaaaga aatcagctgt
    68461 tgaagtattt acaggctctt caaaaacact tatcggtttt ttgatatttg gtattggtgc
    68521 ctctgctatg acaggagcac ttcaaaattt caataaactg ttccaacatg gatttggaat
    68581 tactggtgtt atagcttcac cagaagcagc tacagcactt gcacaaggta catatggttt
    68641 tgcagtttca tgtacattaa ttcttggatt catattaaat ttagtatttg cacgtattac
    68701 aaagtttaag aatattttct ttacaacagg tcatagtttg ttcttttctt gtgtattagt
    68761 tttaattatg aaagcacatg gatttgataa tacaatcact attttaatag gaggaactat
    68821 cttagggttt atgtctgctg cactacctca attctgtcaa ccatttatgc gtgaattaac
    68881 aggcggcgac gaacaagcta ttggtcactt taacatgatt ggttatggtt tatcaggtta
    68941 tattgggcgt ttattttcaa aacataaaga tgatacaaca gagactatag aatttcctaa
    69001 gtggttatca atattcagag acttcttaat gggtctatcc atagttatgt taatcttatt
    69061 ttatattgca acattaaaag ctggtcaagc atttactcaa gaaattgctg gttcaacaca
    69121 ttggttggtt tttccgctta tagaggcatt tacatttgtg gcaggtatgt caatattgat
    69181 gtcaggtgtt cgtatgttct tagctgaaat aactgcagca tttgtaatca tttcagaaaa
    69241 gtatattcca ggttcacgtc ctgcgctaga tgttccaacc gtatttccat atgcaccaaa
    69301 tgcagttatt attgggttta tatcagcata tgctgctggt ctattagcaa ttgctattat
    69361 ggcatcattt cctagtatat ttcctgtagt aattattcca gctgctcaca tatgtttttt
    69421 ctcaggaggt acagctgcaa tatttggcaa tacttcagga ggatggagag gggctattgc
    69481 tgggtcattt gttgtggggt tattacttgc atttttgcca gttatactat atccagttta
    69541 tgggactctt ggtatagaag gagcaacttt ccctaatatt gattacaacg tagttggttc
    69601 gatattacat aatattttac aatttataaa acctatttaa actaaattat ataaaagtat
    69661 agtcatagtt actatgattt caaggaggat acatattatg gaaaatacat tatctgaatt
    69721 tttagataat atatctaatg aattgtcaga atttattgcc tcaatagatg agacatctat
    69781 aaataaagca tgcgaattaa ttcttgaagc tgaaaaaaat cacggacgtg tacatgtgac
    69841 tggtattggc aaaccaggac atgtatcggg atatatttca tcattgcttt catctactgg
    69901 aacgtcagca tatatattgc atggtacaga agcagtacat gggtcaagtg gtcaagtagt
    69961 tgaaggagat gttgttattg caatatcaaa tagtggtgaa actcaagagt taaaagcaac
    70021 tcttaagact ctaaaagtaa atggagcaaa gataattggt gtaagtggta atgagagttc
    70081 atttttaaaa aatatttctg atatattcct gtttgcaggt gttaaacagg aaggagattg
    70141 tctcaataaa gctcctcgtg cttcaatttt agctgaaaca ataatattac aatcattaag
    70201 tgttgtatta caatatgcta aaggtcttaa tacacagcag tatttgaagt ggcatccagc
    70261 aggaagtctt ggaaagtcta ttagagaggg aatataattt tatgaaatat aaagggatta
    70321 tatgtgcaat gataacacca tttgatgaaa atcaaaatat taattcacaa gcaacatgtc
    70381 aattaattga ttatttgatt gaaaagggaa tttatggatt atttattttg ggcactaatg
    70441 gtgaatgtca tgtattaaca gatgatgaaa aagttgaatt tgcaaagatt gttattaatc
    70501 atacaaataa tcgtgtacct gtttttgttg gaacaggggg taattcaact cgtgaagttg
    70561 tagatttatc taagagaatg gaagcgattg gagcaagtgc attatctatt attacaccat
    70621 actttgttac accaacacaa caggaattaa tcttacatta caaaactatt gctaattcag
    70681 ttaatttacc tattataatg tataatatgc caggtaagac tggaattaat attgaaccag
    70741 agtcagtacg tgaattatca aagataaaga atattgttgg aattaaggat agtagtggta
    70801 aacttgacaa catgaaagct tatattgaag caacgaagaa tgagaatttt agtgtgtttt
    70861 caggctcaga ttcacttatt ctggatagtc taaaagctgg tagtcaagga gctgttgcag
    70921 caacaacaaa cttcctcaca gagattggta tctctatcta tgaaaacttt atgaaagggg
    70981 atttggaaga agctcaaaaa gctcaaagta gtatagaaga acttcgacgt atactgaaac
    71041 ttggaacaat tccatctgtt atgaagaaaa ctattgtctt gaatggaatt aatgttggaa
    71101 ctgcacgact tcctgtaact gaaccaactg gggaagtact tgaagaaatt aaacgagtag
    71161 ttgaaaatta taggacaata cttaataaaa gtagtgagaa tagataatat aaatagggaa
    71221 attacactgg tatataatta atatatatat tataaaacat gactaaaatt aatgaataag
    71281 taaagtggtt tgatgagtat agaggtgata atatgaaaaa gatgaatata accaaaagaa
    71341 tgtcagaatg tggggctctt gcaattgtaa gagaagaaaa tcttaaccgt gcatgtgaaa
    71401 ttgctgaagg atgtataaaa ggtggtataa cagttataga aatgagttat accctaaata
    71461 atgctggaga aataattcaa gggcttaata aaaagtatgg tgaaacactt tgtgtgggag
    71521 caggaacagt tttggatagt gaaacagctc gtcatgctat attacatgga gctcaattta
    71581 ttattgcacc aaattacaat gaaggtgtag cgaagatttg caatagatat cagattcctt
    71641 atgctccagg atgtacatca ttgactgagg cagtagatgc actaagttta ggagcaactt
    71701 ttataaaagc tttcccaata tcagatttct atggacctaa actagtaaag gtatttaaga
    71761 caccaatacc tgatatgcca gttttagcaa gtggagggat taatattgaa aacctacata
    71821 tatggttaga aaatggagtt gatgtatgtg gatttggtgg tttattaact aaaggttctg
    71881 ttgaagatat tgctaaaaat gctaaaaaga ttcgtgaaat cattaaaaat gtaaaaaaaa
    71941 tttaacatag ggctgtatca tagtatctta taattactat gatacagcct ttttaatatt
    72001 attcaaattt aaaacagttt acatttctat tatattacat ataatttcag taattttata
    72061 ttaatttttc tatctggaaa aaaatgattt aaaacttaag ttatgatata atttcattaa
    72121 aagaaggcga tttttagtaa atatgagaaa ataatgtgtt tttaggggaa aagttaaata
    72181 cagatttaag tgaacaagaa tcgataatta agatattaaa tggtgaatag ggcatcaaaa
    72241 aaattactaa attaaaagtt ttagagggag aatcttagca agtgtgtgtg aaaattcaat
    72301 ttcaaacaaa aaataattgt aaatgaaatc aatttataca cgttgaagat tcacttttat
    72361 cattatatta aaaagcagag tgaattaaaa gtgagtctaa agataggagg ataattaaaa
    72421 caatgaaaga agacattggg ttacatcgaa tgtgtaaaaa agaacaagca acaaagaatg
    72481 aagttatatc agaggatatt ctaaaatcta tgagtattgg ggtcagtaaa cattttttag
    72541 atgattcatt tacaataata tggggaaata catcattcta tcaattatta ggatatacag
    72601 aagaagaatt tttagttaaa ttttctagtt taaaagatta ttatgaacag aatctttatc
    72661 attttgaatc tatgaaaaat cattttttag aggcttatca tcatggcgaa aagagtatag
    72721 aatatcaaat ttgcatttca gcaaataatg gagaccctgt ttgggtaata atgactggta
    72781 tattaattga atcacaagat aatgagaaat caatggtcta tatattgtat tcaaaaatta
    72841 atgagttaaa aataaagcaa gaagaactat ctgatatgga aaaagagagt acagagaatt
    72901 ttaaatggat gatgtcagag tatgctggga atgtttatat tagcgatatg gatacatatg
    72961 aattactata cttaaataag cactcatgca atactttaca ggcatcagca aatgaactta
    73021 ttggaagaaa atgttatgag gtaattcaag gtagaacttc gccatgtccg ttttgtacaa
    73081 attcgtattt aaaaaaagat gacacatatg aatgggaatt ttataataaa aaactgaaac
    73141 gaacatttat aattaaagac cgtatgttga attggcaagg gcggagagtt cgtattgaat
    73201 tatcttatga tatgtatagt gctgaatata aattagcaaa aaaagatcag gaaagagaat
    73261 caattttgaa aactattcca gcaggaatgg ttagattaga tgcaagagat tatcttacta
    73321 tactttggtg taatgatata tttttgaata tgattgaata tacaaaggaa cagtttgcag
    73381 aggaacttaa taatcaatgt ggatatttat tttctgaaga ttataaacgt agtaagaaac
    73441 tggcacaaga tttgaaggag tctggggata atattgtatt tgaagcaaaa atatatacac
    73501 gttcaaggga agaacgtata tggactgtta cattgtgtta tatcagtggg gaagacagtt
    73561 gggatggaat accatctttt tatagtatag gtattgacat aacaaaggaa agaaaacaga
    73621 ttgagaaatt acagcatata tcagagaaag atgcattaac aggaatttat aatcgtgctg
    73681 agactgaaag gcagattaag aaatattttg aaaaaaattt aaatgttatg ggtgcactgt
    73741 ttatgattga tacagataat tttaaacaga ttaatgatac agaagggcat atgattggag
    73801 atatagtact tactgagatg gcatcaggta tgaaaaaaat aatgcgtgac agtgatgttg
    73861 ttggaagaat aggtggagat gagtttacaa tttttatgaa gaatatttcc tcagttaaag
    73921 atgcagaaaa gaaagcagaa gaactattgt atatgttccg tcatctattt cagaaagaaa
    73981 aaagttttct aaaagtaact tgtagcatag gaatagctat atatccaaag gatggtacta
    74041 cattcaagga aatatatgca agagctgata aagccctgta tcaagcaaaa aatatgggaa
    74101 aaaataatta tgtaatctac aaccaagatt attttaaaga attagaagaa tttgattgtt
    74161 cttctcttgg tacagttatt gattcagaaa aacaatacgc tgaatatcct gataatctta
    74221 cacgttatat attccgtatg ctttatcaga ctgatgatat agaccaggcg attaatatga
    74281 tacttgaggt tgttgggaaa cagtttgatg taagtcgtgt ttatattttt gaaaatacag
    74341 aagatggtag atatacttct aatacttatg aatggtgtaa tgaaggaatc tcttctcaaa
    74401 tggcttattt gcaaaacagc aattatcaag actatgagga ttatgaaaag ctttttgagg
    74461 atgaattagt tttttattgt cgagatatcc atacattaag tcctaaacta gaagaattgt
    74521 tttctagtca aggtatccac tctacacttc aatgtgcata taaagaagat agagttttca
    74581 gtggatttgt tggatttgat gaatgcacag gactacgtct atggtcacaa gaggaaataa
    74641 gtacattatc attgatttct caaattatat caatgttttt acaacgtaaa aaaaataata
    74701 aacttaatca acagattcaa caataccaga atattttaga taatattgac cagtgtattt
    74761 gtgtgattaa taaagaaaat aattttttat tatatgtaaa taaaaaattt aaaaatacat
    74821 attctaaatt ccaaattgga caaccttatt atcttgattc tatagatatt cataagatat
    74881 ccattatatg gaataaaaaa gaagcatacc tatgtactag catgatttaa tggtaaagta
    74941 aagtttatat tggacttaaa ttaaattttg ttttaaataa gatattattt tagttgatta
    75001 ctgaaaagac tagaatctat attaatgaat tatactaatt ttgtaccact attaaaatat
    75061 tgtttgctaa aaataaaaaa tagccttaaa acagttgatt ataaaaaatt aactgtttta
    75121 aggctatttt tatctttgtg acgaaataga cacttgccat ttagaatgtg acaatatagt
    75181 agttgtttag aaaaggcaca aagcattata ctttaactaa agtaaaatgt attttgcttt
    75241 tagaataaaa acaattagga gggagctata attgaaaaag ataatatatg tattatttac
    75301 aattgaacta ttaatagtat ctttattagg tctaaatata gttaaagata atgaaattaa
    75361 taatatttta tataacgata caacaagtat atctgtaatg tttaaagatt ataaaaggtt
    75421 aaataaaaat tatagtaagt ggattaaaga tattgcagat gaaaataatg tgactatatc
    75481 aaagtatgtt tttaataata atgaaaaatt atctatatat acgactgata caagtttgaa
    75541 taacaatata aagttaaaat caggaaaatt tcctaatact aattcaaatg aatttattag
    75601 taatataaac actaataata gtaatcaagt aggtaaattc tcaactatga gtaaagacat
    75661 atcaatttta attagggatt ttggtaaaat aagtgaagtt ggagaatcag gaatcttata
    75721 tatttcaact caaaatgaag atacaataaa taaaatatta aaagagttaa atgtggacag
    75781 aagtattttt atagcaagat tacatgatag atatgttaac tcaaatttat acttaaatcc
    75841 ttcaataatt agagatttaa tactaattat cctttgtttc ttggctacaa taatacatta
    75901 ttcaattagt gtgagtagag aggcttctat tttaagatta aatggatact ctaagctaga
    75961 tataattgct agagttataa aaaatatact tagaattatg attttatcat ctgtcacagc
    76021 attattaata tatataatct atattttaaa attaaatata ggtgttagag catgcttata
    76081 ctttgctatg ttttcgatta tatgtatttt gataaatatt ttgatatcta tattaatagt
    76141 tggttttaat agtagaagtt ctaaatatat gctatctcta aatggaaaaa aatcttatgg
    76201 ttttgtaaat ataatgcatt tcacattgaa aattgtattt atatcatttc ttatattatc
    76261 cataaataac tgtattttaa attataatat gctacaaact cagttaggaa atctatctga
    76321 gtgggataaa gcaaaaaatg tttataatct tactcttaaa gatacaggtg aacaatcttt
    76381 aggaaaggaa gaagtaatta aaaatgccaa gattaaaggt ttctataaaa atttggtaga
    76441 agaaaaagat gctttcttaa tagattcaac taattttgaa aaacttgaag atggaagtta
    76501 catgtatgaa ataaattcaa agggtaaaaa cccagaagta agtcaatatg gtaaaaatat
    76561 aaaaataaat aaaaactatc ttaaagttaa ccctatttac tcaaatggca aagaaatatt
    76621 taatctaatc gattatgacg ataagactat aaatttatta gttcctaaaa agttacaagt
    76681 acatgaaaat gagattaaaa aagagtttag agaattattt tattttgaaa aaatagaagt
    76741 agaaaatatg tacaataaag agttaaatag agagttaaat aaaacaaaga agtcagattt
    76801 aaatgttaat ataatatatg tagataataa tcaaagctat tttacttata actcccttgt
    76861 tatggatgac aataggaatc tcattgatga cccaatagca atagttgaca tagataatat
    76921 tgatgattct ttttatcttt cttatatatc tagatgtgta tattttaatt ctaagaaatt
    76981 agatgccctt gcagatataa gtaacattat tgaagctcaa ggtgtagaag cgcatatcca
    77041 aagtttacat gctgtttata atgagtatgg tttagaaata aataaactag aaaaatattt
    77101 gaatagtgaa atttttacta taataataat agcaatatca aacttaatga ttacctacaa
    77161 tatagtagct agctactatg aaagaaataa atataagtta tatattaaaa aaatatttgg
    77221 ttattcagct acagctagaa gtatgttgtt aatagtctca ttaatattaa caaacattat
    77281 tccaataggc attatatcaa caagagtaga tttaagtaat aatattatct tatttggact
    77341 tctaatatta gttatagaag taattgtatc tattgtatta gacaagatta tctcaaatag
    77401 ttcatttaat aaaattataa aaggagaaca ttaaaaagat gatttcatta ataaatatat
    77461 ctaaaaaatt taaagataaa tctataatag acaaatttaa cctagaaatt tctaagggcg
    77521 agtttgtagc gataacagga aatagtggtt caggtaagac aactttactt aatataatgg
    77581 gattattaga aaaacctaat tctggtgata ttataataaa taatataaaa aatccaaata
    77641 gtaaacagat aagaatttta caaagggatt tttatggcta tctatttcaa aattatgctt
    77701 taattgagaa tgaaaatgtt gaaaataact tgaaaattgc tttaaagtat caaaaaaata
    77761 tcaaccataa tgaaaaaata aattacgcac ttgagtctgt aggtcttaga aaatacaata
    77821 aaaaaaagat atacgaattg agtggaggag aacaacaaag ggtagcatta gcaagagtaa
    77881 tattaaaaga atgtgaagta atatttgcag atgaacctac aggtaattta gataaaaaaa
    77941 atagagacat agtatttgat atacttaaaa gtctaaataa gaatggtaaa actatcgtat
    78001 ttgtaactca tgatttagag ttatcggagc aggcagatag agttataaaa ttgtaataat
    78061 atcaactata ataaatataa gaaagagatt acagctaaat caagtttaat aataatacga
    78121 atagaattta aacattaagt aaattagtag tttgtaaata taagtataat atgatatcat
    78181 aaaggctcaa aagaaatttt atataataag aaatctaaaa ataacaaatg gaggacatat
    78241 aaagatggaa aatttaccaa attgcccgaa atgtaattca gaatatactt atgaagatgg
    78301 aactctttta gtttgtccag aatgctctca tgagtgggca ttaggattgg gagctgaaga
    78361 agattcaaat attatcaaag atgtaaatgg aaatgtatta aatgatggag attctgttac
    78421 agtaattaga gaccttaaag taaaaggaag ttcatcatct ataaagattg gaacaaaagt
    78481 gaaaaatatc cgtttaatcc atgactcatc agatggacat gatatagaat gtaagataga
    78541 tggttttgga gctatgaagc taaagtcttc tgttgttaaa aaagcgtaat attataaata
    78601 agctgtagtg tttattgttt ttcagtacag tataaaacca taagaatcta ttaagtaata
    78661 aaagtttgtt tatttatctt tatattttct tatggtttta ttaaatataa attttattga
    78721 acaccaaaat attctctcct ctacaaataa gccaatctta tttaaactaa tatactttgt
    78781 actatttata ctgaaattgt aaatttaaat g
//
LOCUS       DAEQCW010000006        73183 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.006, whole genome shotgun sequence.
ACCESSION   DAEQCW010000006 DAEQCW010000000
VERSION     DAEQCW010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 73183)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 73183)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..73183
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.006"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(288..1907)
                     /locus_tag="KRO40_000411"
     CDS             complement(288..1907)
                     /locus_tag="KRO40_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBH2091250.1"
                     /translation="MNIVISLIGGLGLFLYGMSLMGEGLQKSAGDKLKKIIELLTSNV
                     VMGVLVGTVVTGIIQSSSATTVMVVGFVNAGIMNLSQAIGVIMGANIGTTVTAQLVSF
                     NLEGIAPIALGIGILFYLFTSNQKTKHLSEILIGFGILFTGMEFMKDAVAPLAEYKAF
                     TDALLYFSKNPVLGILAGFAITGIVQSSSASMGMLIALASQGILPLSSALPILYGDNI
                     GTCVTSLLSSVGASRNARRAAVMHLSFNVIGTIIFMLVLNKPISAIVTHFDPTDTARQ
                     IANAHTLFNLTNVIILLPFSKYIVKLANRLIPIKETESEIVNNTKYLDERMFSTPSIA
                     LGNTVQEVVRMGHKATNSLEHSIAGFLNKSNEDINKAFESEKVVNKLQKDILNYLLKL
                     SKEPLRDDERFRTDLLFNTVNDIERVSDHAENIAELAMSVKEMNISFSDSAIREIYEI
                     YNKTITNFKDALIVLDVKDFELANKVLEVENEVNYLEKTFRNSHMIRLNNGSCTIDAG
                     VLYLDLLTNLERISDHSTNIVKQVLKLKQKI"
     gene            complement(2216..2455)
                     /locus_tag="KRO40_000412"
     CDS             complement(2216..2455)
                     /locus_tag="KRO40_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091251.1"
                     /translation="MNYNLIKVIFSLFKKKSGYTFTNFLNKVRVEKSKKYILKKDLSI
                     LDVAVLIGFNSQNYYSIIFKKFNNFTPIEYKNIYN"
     gene            2726..2917
                     /locus_tag="KRO40_000413"
     CDS             2726..2917
                     /locus_tag="KRO40_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091252.1"
                     /translation="MERLMELIERKFLKDVELLELEDIENVIECKMTQPYNAHYNEYL
                     VKVKNGDEVEEYFVYLKHR"
     gene            complement(3006..3818)
                     /locus_tag="KRO40_000414"
     CDS             complement(3006..3818)
                     /locus_tag="KRO40_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mrp/NBP35 family ATP-binding protein"
                     /protein_id="HBH2091253.1"
                     /translation="MADCNSCPSKGNCNSQSNCSIENNPNNKFGKIIGVMSGKGGVGK
                     STVTALLANKLNKMGYKVGILDSDITGPSIPRLMGVKNVKAYSDGSYIYPVENSNNIK
                     VMSINLMIDDENEPVVWRGPLLGGVVKQFYTDVLWEELDYLLIDMPPGTGDVALTVMQ
                     SIPISGIVMVSVPQDLVSMIVSKAVNMAKKMNINVLGVIENMSYIQCPDCSKKIKLFE
                     GESTEKFLDDLDLELLGELPMTKEIIDITHNGVTEISDDLDSILTNVVEKIK"
     gene            4240..5391
                     /locus_tag="KRO40_000415"
     CDS             4240..5391
                     /locus_tag="KRO40_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004452985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091254.1"
                     /translation="MELRPRSAKLEEFDKVIELINYVFRISRNHKPTMMEEFPLLLSK
                     NNIENMIIISEDDKVVSDVNYLIQDVSIQGNRLKVAAIGGVCTHPDYEKRGYSSKILD
                     KVEEKMFYDGVDIVIISGTRSLYSRRNCSLVKSFYKYTIKPEDVKIAYEIVEFDETNF
                     EKDNDLDKMIELYNQNSTRFIRTRDEFQKLLHAATIAWGPIGYKKVFIKENNNIIGYL
                     IIRTIKKEDSTVGEVAEIGLNSVNVENILKYVANKFGLESLNYKVHVKNLKDQLKCNG
                     TKSLDYQQGTMKIINFTKLCDSLRSYFSQYVDFELLKYMEFKQVENKYIIKYKEEELV
                     IENLDKLNKLFFEKNEEQYNEFKHLKNIYEFATKAFPVDFPWTANLNYQ"
     gene            5509..6147
                     /locus_tag="KRO40_000416"
     CDS             5509..6147
                     /locus_tag="KRO40_000416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423639.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBH2091255.1"
                     /translation="MDILDDIAECILNMGVDNIENLVKIAIDKNIDVEDIYEYGLNKG
                     MIGALDKFENKEYYLSEVIVCTDALNKGINLLKGTGKVKKKSKGVILMSVVEGDTHEI
                     GKNIVKVMVEATGYKVIDLGVNRKSEDIIEEAIKNNVDIIGLSSMMTTTMENMKSVID
                     ELNMIEIDKRPKVIIGGGPVSMEFAEEIGADGYSSNAPKAVKLINKLIGGEV"
     gene            6148..7170
                     /locus_tag="KRO40_000417"
     CDS             6148..7170
                     /locus_tag="KRO40_000417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase"
                     /protein_id="HBH2091256.1"
                     /translation="MFSDMTLLQYINSEDRGFFLPDMGTNGLFLINKKAYEVYDSVDL
                     QLELAKTMDKYFESDFIYSFCDGITFCETLGLDTLRPDYDFPSVLTHTITDRDKLRKL
                     DVPDPYTSGRMPLNIESLSVISKSIKKPLYESIQGPFTLAGQLAGATQLLRCIITDKK
                     FVEELLEFTTELVRRYAVAANKAGAKYISIAEPTSVTLSKDRFDEFIVKNLNKIYNEL
                     DCWKGMHICGDTRELLDNMLSCNIDAVSLDQILDYEEIAPMIPRDIVLIGNLDPIKLL
                     GRSKPDKIRRETLKLLKKMRRYDNFLCDFGCNCLNTTPVENLQAAIKAGRISYKELDR
                     IDIDEL"
     gene            7160..7780
                     /locus_tag="KRO40_000418"
     CDS             7160..7780
                     /locus_tag="KRO40_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091257.1"
                     /translation="MNYNSNKNKYLLKDINLDDIFIDKNIVLKFLGYGNRKAPDTISK
                     IVEREIRNINDILDIKIYISEVDINKTPKECKKAFAVLYTIGDKIDFKMNDYMENCNM
                     MAGLALDKVGIVCLDCINEKIKMYLKGKYDSLKISHEIYPGDKDFEVERQKDIYNYVK
                     NKYNSIEIEINDYHQLSPIKSVAMLILMGDEENLESRCSKCPRKCF"
     gene            complement(7904..8590)
                     /locus_tag="KRO40_000419"
     CDS             complement(7904..8590)
                     /locus_tag="KRO40_000419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HBH2091258.1"
                     /translation="MKTYKFIFFDADDTLFDFKKSESHAFKKLLSEFDLEFNFENYIE
                     SYRNISDKLWLDLEKNIITLNELKLLRFELFANKISLDVDSETLSKMYLNFLGECTFL
                     IPGAIDILQYLKKKYTIVIITNGISAVQKKRLENSKIKEYIDGMVVSEELKISKPNPE
                     IFKYALKKFNCHDKSSALIIGDSLTSDILGGINSGIDTCWLNSNNSINYTNHIPTYEI
                     NTLIELKKLL"
     gene            complement(8604..9149)
                     /locus_tag="KRO40_000420"
     CDS             complement(8604..9149)
                     /locus_tag="KRO40_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091259.1"
                     /translation="MNDLNLGEKIAEVRKKQNLSIRDLAKLADVTPSLLSQIERGLAN
                     PSVNSLKSIASSLNVPLFTFFVSEVDKKNLIVRHDNRKKVILPGSKEVIYEILIPDSS
                     GNLEFAIMDLAPNTSSCVDRITHNGDEIAYVLEGEVKLFMDDDEFTLSKGDSVKVPLG
                     TKHKWQNDSNSESKVIFAVIL"
     gene            9377..10624
                     /locus_tag="KRO40_000421"
     CDS             9377..10624
                     /locus_tag="KRO40_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH2091260.1"
                     /translation="MQITTFGAIFGLLIAIILIIKKFQAVYSLMLGAFIGGLVGGANI
                     TQTVDFMANGAMNISPSILRALASGVLAGSLIKTGAVDKISEQIVKIFGEKRALFSIA
                     ISTMVLAGVGVNLDVSIITVAPIGLYIGRKLNYSKLSILLAMLGGGKAGNIISPNPNT
                     IAVADNFSVNLSSVMMANIIPAIIGVVITVILASILINKGNKVQSYEILEQREDLPSL
                     FKSLCGPIIAIFLLFLGNVSPIVIDPMIALPIGGIVTLIVTGNLNNSREYLAFGLSKM
                     QGVCILLLGTGTIAGIIQMSELQQSTIGALQFLNMPQFLLAPVSGILMSLATASSTAG
                     ATIASSTFHDAIINGGLSPISGASIVNAGSSVFEQLPHGSLFHTSAGSINMDIGERFK
                     LIPYEALIGIVMTIISTSIQLVL"
     gene            10711..12705
                     /locus_tag="KRO40_000422"
     CDS             10711..12705
                     /locus_tag="KRO40_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH2091261.1"
                     /translation="MNKKKIVIIGIIYSFLVVFSLTNMYVNMEYNLNVFEYIKKSLPF
                     TEEEKKWLEKHKNLIYSSDQSSPPLRYKGKEDGQYKGIIVDLINSLSIQIGRDFYFKP
                     NNWWKESFVNSIDDSIKFFDLIPSKERANKFIFTDPIYTLSANILKDKKSQDINSYMD
                     LKGKTVAIPEGDYSINFLKQKIQDINILLTPDIKTGVNHLMSGKVDAVVGDEPVLRYY
                     INNYGLSNKYSVLSNPIYTKKAVLAVPKQYEELVSILNKGIFKLQKNGVYKDLKKKWY
                     STYNEVDDILYERGIVPSIYLFIGIILISIYVFYSYTYLLKIEIKRKTEQVIENKKTL
                     EATFNSITDIIMLVDENNNIVESNKVLYDFMGEMSYKIADLISMIKGVIENTFSENTN
                     KTSEIEIHNKILKINTFPVEYKKNNTEYIVVLIKDITNDKIVEAKLLRENKMISIGQL
                     ASGVAHEIRNPLGIIRNNCYLLKDNVTMEEVNDCVKSIESNVDRASNIITNLLNFARI
                     SDDNLEHINIRNFIENIVKLQYKMLQLKNVEIKIDCEHNLVCYINGESLKHVFINLIS
                     NSIDAIHQDGKIIIYCYEKNYCLFIDFKDNGEGIKEDALKDIFNPFYTTKPIGEGTGL
                     GLYITYNEIKKNNGDISVESKLGVGTCFHIKIPLNKEVTI"
     gene            12705..14027
                     /locus_tag="KRO40_000423"
     CDS             12705..14027
                     /locus_tag="KRO40_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBH2091262.1"
                     /translation="MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDK
                     NYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVTGYGSIENAVDAMKRGALSYFIK
                     SNPIENLLEEVEKVKASKISVSVQKNNLEFTLESKNRDFNNIIKIAKKAACKDVNILI
                     LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSR
                     KGRFELSNKGTLFLDEIGDIPLNVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNK
                     EPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFLNKYQIEHDKKIHSI
                     DKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRP
                     LREIRKEFECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK"
     gene            14306..15592
                     /locus_tag="KRO40_000424"
     CDS             14306..15592
                     /locus_tag="KRO40_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006807454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBH2091263.1"
                     /translation="MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIV
                     SVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFPGIINKVKTVGSGRTHVLLGACV
                     VTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
                     GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVD
                     AKQIVPTFMYPTEIMDGAIISGNCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGV
                     ILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTDLMMNCRKCSEVGAN
                     VVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIG
                     GYKGCLNEDGSMDAELQIIIASTIANGYNHLTARYY"
     gene            15678..16985
                     /gene="grdB"
                     /locus_tag="KRO40_000425"
     CDS             15678..16985
                     /gene="grdB"
                     /locus_tag="KRO40_000425"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:16725..16727,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBH2091264.1"
                     /translation="MSKIRVVHYINNFFAGIGGEEKADIPPEKRAGVVGPGIAFQSQF
                     NDDAEIISTVICGDTYFGENIESATQELLKMIKEESPDLFIAGPAFNAGRYGVACGTI
                     CKAVEEELNIPVITGMYKENPGVDMFKLDLHIVSTGNSAASLRKVVPIMTKLGLKLVR
                     GEEIGPPEEEGYIMRGIRKNFFHELRGSERAIDMLVKKMKGESFETEYPMPEFDRVTP
                     MKPVKDLSKIKLALVTSGGIVPIDNPDKIESSSATKYGIYDLTDMDSMSNKEFTTIHG
                     GYDRAYVLENPNLVVPLDVVRELEKEGVIGELVDYFITTTGTGTSVGNSKRFGEEFSK
                     KLLEDDVDAVILTSTUGTCTRCGATMVKEIERAGIAVVHICTVVPISLTIGANRIVPA
                     VGIPYPLGNPMLGEEESKKIRKNIVLKALNALTEDIEEQTVFE"
     gene            17263..17994
                     /locus_tag="KRO40_000426"
     CDS             17263..17994
                     /locus_tag="KRO40_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091265.1"
                     /translation="MIRKKVYILISIAICDDESYMLNHLKENIELYMKQKNLLYNIEL
                     FNKVEDLLCNHEKFNIVFLDIQMEEINGMQAARKLRSYGNECFIIFVTVLNEFVFDAF
                     EVDAINYLIKPLSNEKLYKTLDKIVTKLDDNESNYITIQKGYSYWKLKLADILYCEVI
                     KRKIYVHLKKETVDYYETIENLERSLPTNFFRCHRSYIINLQYVYGYENGNAVMESGD
                     RIPVSRLRQQIFSKVMLEFMKNRRI"
     gene            17996..19354
                     /locus_tag="KRO40_000427"
     CDS             17996..19354
                     /locus_tag="KRO40_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2091266.1"
                     /translation="MINLFSSDLFLKYSFLFSFIVYRILMVIVQYYFLISFTNVNSKF
                     WCFILYSIISIFLIIINTYFNLYNLFSSQILFFLMTFLFVKYIIKQSTVLSIVSTLLV
                     YLIEQLVYGFTAPLNYLIFTSDINTDIYKFDINMGLSSLITIIIAGFIYWYSSKKFNI
                     KVMNFDKYIAILMIPLLLIILFMQSFEYSSNINIDTSLGIVKLLLNTSITEEIQAFLF
                     SIIGTICVFFSLFTFKKLIQALEDDKERAIMNQQIHAQKNYIEEAKSRLSQTISFRHD
                     FNNHLAIVNGLLKKDQILKAQDYLNKLEKVTSDLSFSCNTQNIVIDALFNNKLSIAKQ
                     LGIEVDCEVIIPQSTNMNDFDLCIVFANAIDNAIKACRVVDKQNRYLKLSTKLEGGFF
                     MIEIKNSYNPINNYTSGSGIGLLNIKEIAKKYQGAISIDKTSDYFQINVLLVISLHCA
                     SI"
     gene            19393..19878
                     /locus_tag="KRO40_000428"
     CDS             19393..19878
                     /locus_tag="KRO40_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091267.1"
                     /translation="MYLNRESLIYRNEEVTKMKVGNINGQAPITNGLDSCQSEVQGLE
                     QKKKSLQDEIEKVRSDKSIDGETAKLKIEALKKEMEEIENKIQELKGNKAKKTNKEEN
                     NVSEVNNNLLERKKEPSNNENVKQLYDVFERSNVDEQWDNTYRVLQDDKNLKVKFNRP
                     I"
     gene            complement(20141..20377)
                     /locus_tag="KRO40_000429"
     CDS             complement(20141..20377)
                     /locus_tag="KRO40_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091268.1"
                     /translation="MLLTHIYFNGQFKQTIELYKQAFNATVKTLIEDSCYLLIVHNEI
                     VIHNKFLILNDFGNKNGVSISEGYQPTDKIQTAS"
     gene            complement(20532..20756)
                     /locus_tag="KRO40_000430"
     CDS             complement(20532..20756)
                     /locus_tag="KRO40_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH2091269.1"
                     /translation="MTVYNLKLGQKGIIDNIAGNEKLMKRLLALGLIDGTEVEVKKIA
                     PLNDPIVIRFRGFDLAIRKSDAKNINLKNN"
     gene            complement(20853..22106)
                     /locus_tag="KRO40_000431"
     CDS             complement(20853..22106)
                     /locus_tag="KRO40_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:glutamate symporter"
                     /protein_id="HBH2091270.1"
                     /translation="MITLSFDIVQTLTLSIFFFLIGNLLKNKVNFLNNFCIPAPVIGG
                     LLFCFLNLFFKYFNIADISISGNLMPNFITFFFTTIGLEISINLIKKGGSVLFRYWIL
                     CGVLAFCQNILAITISKIIKLEPLLGLMCGNVSMEGGHGYSAAFGLTIENLGIEGAVG
                     VGLSAATIGLIMGGILGCPVAKFLINKYKLKPSSNIDLSIPRYNRNLKRFGSKFFRNK
                     NRIKNNNFSETITPSVFLEQVLLIFICINTGEIISRCFYITFNILLPSVVTCMFSAVI
                     FRNLNDKINILELNFKLIDFLKELSLGIFLTLSLMNIDLFELSTLLPPILLIVTFQVI
                     FIILFSIFICFRVLGKDFDSAIIISGLIGHGIGATPNALANMSSLTQKYGDSPKAFLV
                     VPLVSGFLLDAISIPCILFFINILT"
     gene            22366..23355
                     /locus_tag="KRO40_000432"
     CDS             22366..23355
                     /locus_tag="KRO40_000432"
                     /EC_number="3.5.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosine deaminase"
                     /protein_id="HBH2091271.1"
                     /translation="MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKK
                     LAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITFELLEDASRENVKYIEIRFAPLL
                     HTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
                     GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRI
                     GHGVKIKDHKKAYNLVKDKKILLELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINT
                     DNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKETKEYLNSLI"
     gene            23427..24167
                     /locus_tag="KRO40_000433"
     CDS             23427..24167
                     /locus_tag="KRO40_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EcsC family protein"
                     /protein_id="HBH2091272.1"
                     /translation="MKDYEDVVYIKLVKKELEEWKKNILKKPSIFDKASKGIQNKFNG
                     VLPDKYHEIITSSIKVMTKTVLFGYKYATKPPLRNMSLEEREKLVLEKAKTYKTTAMI
                     EGAGTGAGGILLGLSDFPLLLGIKVKFLYDVASIYGYDVKDYRERIYILNILQLAFSS
                     QQHINKTFKLMNNWDEYVNSLPEDINDFDWRTFQQEYRDYLDLAKFLQLMPGIGAFVG
                     FYVNGKLIDKLCETAVSAYRLRIRELKL"
     gene            24383..25534
                     /locus_tag="KRO40_000434"
     CDS             24383..25534
                     /locus_tag="KRO40_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBH2091273.1"
                     /translation="MTNLPKQFDSFNEARQKGFINAKELKESGKKMVGVFCTFTPVEI
                     PMAAGATVVGVCGVSEEPIPDAERVLPRNLCPLIKSSYGHAITDTCPYFYFSDLLIGE
                     TTCDGKKKMYEELAKVKPTYVMHLPNTSKGEFAYKLWKDEMIRLKEEVEKSLGVTITE
                     EDIRTAIKDKNEERELLKEFYALGKLQPSALTGLELHNVLYQAGFKFDRAELKHSLRK
                     VIDDMKERYEKGECPVQKDKPRILITGSPIGGISEKIVKTLEDAGASVVAYELCGAIR
                     SNDLLVDEEIEDVYDALTQKYINIGCSCMMNNDNRIELLDRIIDEYNVDAVIDVVLQA
                     CHTFNIESYRIREFVTKEKNKPFMSLETDYSKSDTEQLRTRFEAFVEML"
     gene            25559..26314
                     /locus_tag="KRO40_000435"
     CDS             25559..26314
                     /locus_tag="KRO40_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyglutaryl-CoA dehydratase"
                     /protein_id="HBH2091274.1"
                     /translation="MFSIGVDSGSVATKGVLFDGEKIIKKIIIPTGWSPKSTSKQVYE
                     LLSSEIDKKDIKKVVGTGYGRGVMDFADKKVTEITCHTRGIYFLNKNIRTILDVGGQD
                     SKVINLDRDGNVFNFIMNDKCAAGTGRFLEITSNLLGSDIESIDTLAKGYEPVNISSM
                     CTVFAESEIVSLLAQNISTGEVAAGILKSIANKSTSMLARGEVIDEVAFTGGLAKSKE
                     LVKMIEEILGKKIFIAEDTQIIGALGAAVIGFR"
     gene            26506..28893
                     /locus_tag="KRO40_000436"
     CDS             26506..28893
                     /locus_tag="KRO40_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding cysteine protease Cwp13"
                     /protein_id="HBH2091275.1"
                     /translation="MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEY
                     SETYKQYLNDAKNGCTEKYNGIIPNPYQLEGTQIQSKGRTAPTSYDPRKLGLMTSIKN
                     QEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVNDMNGALNYE
                     AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTK
                     NAILQYGAVTSGYYEDIKYQSDDQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANI
                     RPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKGGKKPNDDEKMYQHD
                     YASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNM
                     KKLKEGTAQYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAK
                     ANLGESYIIDNTGKFFDINRDSNFYPCNFTIKAVTEKSSGESIPNESLIGSDRYETAI
                     KVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKAEIQRLG
                     AKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAV
                     VNGVKGLADAISVGAAAAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLS
                     NNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNAFVVKNGIKNQNDLIDGLAVG
                     PLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK"
     gene            complement(29124..29357)
                     /locus_tag="KRO40_000437"
     CDS             complement(29124..29357)
                     /locus_tag="KRO40_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HBH2091276.1"
                     /translation="MATTTKNRFYDYVQENLNKYVEVHSYFSSCPLYGEIIEADSLSI
                     TLCSRYIDESNPTLNETYTLYLPLSSIISIRTL"
     gene            29646..30236
                     /locus_tag="KRO40_000438"
     CDS             29646..30236
                     /locus_tag="KRO40_000438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091277.1"
                     /translation="MPKSYSDKEREYIIKRLKEEARLCMEQYGIRKTTVDELVKRVKI
                     PKGTFYLFFQSKELLFFEVLRDIHDSIQKEILYEINRVDESITCEQLTDIFMKFYRMV
                     DSTSILNLMINGEFEILVRKLPDSIIEEYFRHDDFEIGEIISCIPNAKNKDIESFSGA
                     FRAVFLTMLYKREVGSNCFEDALRLMINGLVIQLME"
     gene            30350..31195
                     /locus_tag="KRO40_000439"
     CDS             30350..31195
                     /locus_tag="KRO40_000439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091278.1"
                     /translation="MIKVDDLSFSYTDRDFLQNINFEVGKGEILGFLGPSGAGKSTLQ
                     KILIGMITNYGGSVIVNGVESKRHSNKFYENIGVDFEFPSLYEKLTAIENLKYFGSLY
                     SKKLLSIDELLKSVGLENESNKRVSEYSKGMKSRLNFIKALLHNPDILFLDEPTSGLD
                     PSNSKVMKDIILSEKSKGKTIILTTHNMLDATELCDRVAFIVNGKISALDTPHNLIMS
                     KGAIKVRYTYFDNGEKTSECFLNNTANDKNLNMLIEKNKLLSIHSSEPTLNDIFIEIT
                     GRNLQ"
     gene            31192..31875
                     /locus_tag="KRO40_000440"
     CDS             31192..31875
                     /locus_tag="KRO40_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091279.1"
                     /translation="MRLKNLILGDIKFQFKYGFYFLYLFLSIIYICIINVFPTFMREK
                     IAIIMIYSDPAAMGLFFMGAIVLLEKSQRVLNSLAVSPVKVSEYILSKVISLGVISSI
                     VAMFIAITLNLDNIIISTIGTFFSSIIFSLLGLIIASKASSLNQFIVLSIPIEIICFI
                     PPILNVLLDTKSYANLYPFNICISLISGDKNFIMINILILISIIIIIYFITYYFICSS
                     WKKVGGVKL"
     gene            31872..32588
                     /locus_tag="KRO40_000441"
     CDS             31872..32588
                     /locus_tag="KRO40_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091280.1"
                     /translation="MIKIINAFKQEFEQIKRDAMLFIVCVSPILCGVFIKFGIPLIQN
                     ISLNKFYYQLNLEPYFLMFDLLLAFITPFMFFFASTMVILGEIDDSISRYLIVTPLGK
                     TGYLISRFGIPGILAFIITMILLIFFSLTKISLLLNLSISLLVLLQGVIISILVISLS
                     SNKLEGMVITKFSGVFMMGILAPFFILNKAQYILFFLPTFWISKAFKEDNYVYMFISI
                     VISLIWILLLFKKFSKKIVK"
     gene            32685..32948
                     /locus_tag="KRO40_000442"
     CDS             32685..32948
                     /locus_tag="KRO40_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091281.1"
                     /translation="MKNKIKILREKLGLTQEQLGRLVGTSRQAINAIETGKNEPSIWL
                     AYDISRIFNEPIESVFLFEESERKSRAQISRGEYYGYKKDKNI"
     gene            32920..33375
                     /gene="def"
                     /locus_tag="KRO40_000443"
     CDS             32920..33375
                     /gene="def"
                     /locus_tag="KRO40_000443"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBH2091282.1"
                     /translation="MAIRKIRTFDDEILRKKSKYVENVDNKIREILNDMAETMYNTPN
                     GGGLAACQVGVLKRLVVIDLGEGLIKLVNPEIIEQEGEQIVVEGCLSFPEVWGKLKRP
                     KKVTVQALNEYGEKIEIKGSGFMAKCLCHEIDHLNGIVFTDKIIEHVKL"
     gene            33427..33888
                     /locus_tag="KRO40_000444"
     CDS             33427..33888
                     /locus_tag="KRO40_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine dimer DNA glycosylase/endonuclease V"
                     /protein_id="HBH2091283.1"
                     /translation="MRLWHKDLIDVLPKNQLVSQWRELLAIKGSIDKKGTPNHLLVNK
                     VLNYSIDEFKFYTKIVHDEMLKRNYKPNELKYTSILKWKNRNFANDISNEHSLNLENL
                     YDDWHNKMYLKQCLYNLEEKATCGGIPINEWNILLCKYSKDYELWSGNIMF"
     gene            33938..34840
                     /locus_tag="KRO40_000445"
     CDS             33938..34840
                     /locus_tag="KRO40_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2091284.1"
                     /translation="MYNKIKYIPINCEIACNKLKRSMPYKWDLNIYRGCEHGCKYCYA
                     IYSHKYINSNNYFEEIYVKTNIVEKLERQLKSSKWKKEVINIGGVTDSYQPIEADYKI
                     MPEILNLLIKYKTPAIISTKSDLILRDYDLIDKLSRITYINVASTITTVNEDTQRLIE
                     PNGVDSMRRFKMLKEFRKTNASVGLHIMPIIPYITDDFDNINSLFRHAKECNVHYVLP
                     GTLYLRGITRGVFFDFVKKEFPELFDKLSILYSAGSLNREYKNQLYKMVNELRYKYSL
                     SSSYSKIMKEKLKNSGDVQISFFD"
     gene            35210..36022
                     /locus_tag="KRO40_000446"
     CDS             35210..36022
                     /locus_tag="KRO40_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2091285.1"
                     /translation="MYLERPELYKQSEINFWDDEYISKQLLKAHLDTNFEGASRNFNF
                     IEDSVNWIVTVANPANYPKLLDLGCGPGLYAEKFAQKGYKVTGIDFSKRSINYAQNRN
                     KETNLNINYLFQSYLNMNYNEEFDLATLIYCDYGALSTENRRLLMEKIYDSLKPGGKL
                     ILDVFTINKYNNFEEIKYWEINEDGGFWSNEKYMCLQDNCKYNDYNTLEQTLVITEKD
                     ENVFYVWNHYFSKESFLLEVENIGFKSVEFFSNVKGEAYSDDSMTMGLVLQK"
     gene            37070..37831
                     /locus_tag="KRO40_000447"
     CDS             37070..37831
                     /locus_tag="KRO40_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896901.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH2091286.1"
                     /translation="MIGIYFSGTGNSRYCVEKFLQEYDITANSYSIEDNELLQHINNH
                     ENIIFSYPVQYSNVPKILKDFIINHSTLWNGKRVFIIATMALFSGDGSGVLSRILKKY
                     GAITVGGLHVKMPDSIGDEKVLKHSLEYNRKLVIKAEKKVTKAAKKLKHGSPPKEGLG
                     FLSHIVGLFGQRLYFINKTNMYTDKLKINTEECIVCGKCVNLCPMKNLVIKNCMIVAN
                     GQCTMCYRCVNNCAKKAITLLGKKVVEQSNIKKYM"
     gene            37896..38678
                     /locus_tag="KRO40_000448"
     CDS             37896..38678
                     /locus_tag="KRO40_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBH2091287.1"
                     /translation="MEYYIVDSFATKLFKGNPAGVCVLDRRIPLELMQKIAEENNLPE
                     TAFVVKGKGNYELRWFTPKAEIDLCGHATLAAAYVISNFIDVNVKRIDFFTQSGKLEV
                     TRNGNLYEMIFPEIMPIEIELSPQQANLIGCVPSAVYSSRDLILLLNSEQEVINYKPN
                     YAQLRKLTDWLGIIITAQGSNTDFVSRYFCPELDSEDPVTGSSHCNLIPYWSEKLGKH
                     KMVAAQLSNRGGIIQCEVLKDNTVKISGEAVLFMQGTIKIDI"
     gene            38945..39364
                     /locus_tag="KRO40_000449"
     CDS             38945..39364
                     /locus_tag="KRO40_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjdF family protein"
                     /protein_id="HBH2091288.1"
                     /translation="MDKISGKLTVLFEEPFWVGIFERQDGKKYEACRVVFGAEPKEVE
                     VYEFILERFFSLDFGSIKLEKNVTKDNIGYKRMQRKVKKEQEKETIGTKAQNALKLQY
                     EERKQDRKNLAKNRKEEEKERLFNLKQEKRKAKHKGH"
     gene            complement(39467..39733)
                     /locus_tag="KRO40_000450"
     CDS             complement(39467..39733)
                     /locus_tag="KRO40_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HBH2091289.1"
                     /translation="MKNFILIYFIVINSIAFFSMYIDKKRAIRNEWRIKEATLMSIAV
                     IGGSIGSIIGMYSFRHKTKHIKFTFGIPFILFLQFLLVYFYILK"
     gene            39960..40661
                     /locus_tag="KRO40_000451"
     CDS             39960..40661
                     /locus_tag="KRO40_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091290.1"
                     /translation="MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISID
                     RVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPHINPIV
                     DLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG
                     DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE
                     IKVGFVDKDNPEMEI"
     gene            40743..41351
                     /locus_tag="KRO40_000452"
     CDS             40743..41351
                     /locus_tag="KRO40_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH2091291.1"
                     /translation="MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSE
                     QLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFRVPINGYIYELPAGLVDEGESID
                     ISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
                     EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE"
     gene            41675..42139
                     /locus_tag="KRO40_000453"
     CDS             41675..42139
                     /locus_tag="KRO40_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4624 domain-containing lipoprotein"
                     /protein_id="HBH2091292.1"
                     /translation="MKKLVIILISIISMVSLTACKKSNESKYNNLNNKESGQTTIEMD
                     LDKNYDTSDPFVNARLFCVSNDIDVLDTEISFKMDGDSGIVEIKDNKTDETLWSNTWH
                     GSVDNDTFTISLSNIQKEKEYAICFTGIKINHAVVKVTFESNLVKEKEKPSK"
     gene            42776..43792
                     /gene="gap"
                     /locus_tag="KRO40_000454"
     CDS             42776..43792
                     /gene="gap"
                     /locus_tag="KRO40_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBH2091293.1"
                     /translation="MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVAINARATTESLA
                     HLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRYNDPEELPWKELGVDIVIESTGL
                     FTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
                     APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKA
                     VSRVLPQLEGKLNGFSLRVPTPTVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVL
                     GYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEWGYSSRTVDLVKYVA
                     EKLK"
     gene            44187..45356
                     /locus_tag="KRO40_000455"
     CDS             44187..45356
                     /locus_tag="KRO40_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091294.1"
                     /translation="MEKLTDRRQVKAVSMETFIFLILLVVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLETVFLIMAMAVLAGALSALLSEFGVIALINKIFAVFMKPLYGLPGASIA
                     GAITTYLSDNPAIIPFAKDKTFTQYFKQYQVPALCNLGTAFGMGLILTTFMISQGTEY
                     VLPALIGNLGAIIGSVISVRIMLTFTKKFYKYNPEEDKATGTLEKKDEFREIREGNVF
                     QRALDAILEGGKMGVDMGMAIIPGVLVVCTLVMLLTFGPSTDPVTGQEVYTGAAYEGI
                     KLLPVIGDKLGFILEPLFGFTSPEAIAFPITSLGAVGAAMSLVPEFIKSGAITPNDIA
                     VFTAMGMCWSGYLSTHIGMMDALNARQLAGKAILSHTIGGLCAGAAAHFIFTLVG"
     gene            45736..49989
                     /locus_tag="KRO40_000456"
     CDS             45736..49989
                     /locus_tag="KRO40_000456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBH2091295.1"
                     /translation="MDELFHIGIDVGSTTVKVVVLNNSNNIVHKEYRRHYSDVKKSVK
                     EVLNGIYEKLGDINTTIIITGSGGIGISKKLGVKFVQEVISSTKSIEYFHPETDVVIE
                     LGGEDAKITYLSGGIDQRMNGICAGGTGAFIDQMASLLKTDASGLNELAKGYNVIYPI
                     ASRCGVFAKTDIQPLINDGANQTDIAMSIFNAVVVQTVSVLSCGRKIEGNVAFLGGPL
                     YFLSELREAFKRVLDLKDENIIFPENAQLYIAIGAGLLSVDEDNIQLKSLIEKLDSIK
                     NIEDGEVNLLEPLFKDKNEYEEFSRRHEKEKINYVDINSIKSNCYLGIDAGSTTTKAA
                     LIDEDGRLVYSYYNSNEGNPLKTTIKVINEVYDILPKNIKILSSTVTGYGEGLIKKAL
                     KIDNGEIETIAHYKAAKFFNKDVDFILDIGGQDMKCLKIKDGVIDNIILNEACSSGCG
                     SFLETFASSLSMTIEEFAHEGIYSQNPVDLGSRCTVFMNSRVKQAQKEGASVGDISAG
                     LSYSVIKNALFKVIKIRDLNEIGNNIVVQGGTFYNDLVLRSFEKLIGKNVIRPNISGI
                     MGAFGSALIAKEKYESGYKTSLLSKEELNNIKLEASVTRCKGCSNHCLLTINKFSDNE
                     IFISGNRCEKGEAIYGDKKIGLEKKKPINLFKYKYNRIFRYKPLEKEEAKNGEIGIPR
                     VLNMYEDYPFWFTFFNAMGFRVVLSDRSSKQLYETGITSIASETVCYPGKLVHGHIEN
                     LIAKGIKNIFYPSVTNENKEDSNADNYYNCPVVISYSEVIKNNVENIRNKNINYINPF
                     ISLNDKEKLKKRLYDELSRHFSDIKITKEEVNHAVDKATDEQNLFKMEIQAAGERALK
                     EIKERNMKGIVLCGRPYHIDPEINHGMPELINSLDMAVLTEDSICHLANVQRPLRVVD
                     QWVYHSRLYKAASFVRDKNYLELVQLNSFGCGLDAVTTDQVQEILNEKSKIYTIIKID
                     EGNNLGAAKIRMRSLKAAMFERESKNIDVKNIKVNRIQYAKNNQITNKHTILAPQMSP
                     IHFQFLEKAVNLSGYNIEILKDTDSSVIEEGLRYVNNDACYPAIIVVGQLITALKSGK
                     YDLNNTSVTITQTGGGCRATNYIGFLRKAIYDAGFKDIPVIALSVNGIEDSGIMDNIS
                     LKLINRLFMSVVYGDLLMKVLYRVRPYEKVTGSANALYEKWVDICKSSLVKAKISVFT
                     RNIKDIVKEFDNLEILDIKKPKVGLVGEILVKFHPIANNNLVDILEREGAEAVVPDLT
                     NFFLSCAFNTIYKHTHLEGSRKSRMIGEAFIYITGIYQRVYKKALDKSERFYAPANIK
                     NVAKSTEPVVSLGNQTGEGWLLTGEMVELLNEGVENIICMQPFGCLPNHIIGKGSIKE
                     LKRLYKNANIIPIDYDPSASEVNQLNRIKLMLSKAFKNI"
     gene            50138..50632
                     /locus_tag="KRO40_000457"
     CDS             50138..50632
                     /locus_tag="KRO40_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBH2091296.1"
                     /translation="MSLVYDVYKSKLGNLYILSEDGFIVSIYIGDEKFNNLKNECIKK
                     GIDIKRSKEDLKEAISQIDDYFNGKRKVFNLNIRIEGTEFQKSVYREMLKIPYGETLC
                     YSDIARNINNPKSVRAIGQASKSNKIPIIIPCHRVVGKKDIGGYMGNHSDLKEILLNL
                     ERQS"
     gene            50748..51125
                     /locus_tag="KRO40_000458"
     CDS             50748..51125
                     /locus_tag="KRO40_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="monooxygenase"
                     /protein_id="HBH2091297.1"
                     /translation="MCDKVIASKYHEKGFNCAESVIKAYNEEFNTDIPVCLGSGLGSG
                     CGVASLCGAVNASNIIIGYVKGRNHEDESTKAKVYAKDLTTTVRKEYGSELCIDLKKD
                     LVACREIMDFAYDSLKETLKKEL"
     gene            51331..51771
                     /locus_tag="KRO40_000459"
     CDS             51331..51771
                     /locus_tag="KRO40_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufBD protein"
                     /protein_id="HBH2091298.1"
                     /translation="MKNLNLLINKLYSKNHNEAYKTFLFLENESLKSNITYCFFDSFL
                     EMIDNENSYIRTRGLLLISANAQWDIDNKIEINIDSILSHIVDKKPSVSRMFIKSIPN
                     ITKYKENLINRIKMELSNADISIYNNNMKPLVEKDINDTLSNIS"
     gene            52430..53737
                     /locus_tag="KRO40_000460"
     CDS             52430..53737
                     /locus_tag="KRO40_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091299.1"
                     /translation="MKEIADAITSEYLSYGINEDISIYEGRFCIYLDKKYRCNGKIYY
                     KMTPPISISFKADIGCVEEIDNEDDNLALDYDNAILEVHGYKIISITINTLSEFSVEG
                     YINDDCIKSKNSYVEYVDFNIINLDKIPGKLIKYNDKVYAGRIEFDINDYVVTIDKRY
                     DYRKELKSELKSKSGAIITHIGRIRRKDGRIFRTNNTINLLDRISTALSFMCGRYVGF
                     CLAKGYRSGNEVYRIWNENQISPFRYVPTWSDTLSNYYNMEKYISLMCKKLEDFYYGS
                     AIKSVVDWYIESLGSATMENNIISVQIALETLSYVILVEQNKILTDEVFDCNLASKNI
                     RLLLDTCKIPYGKHELNIFDNIIKNKFDDGVDLVIYLRNSIVHPSRKTHRAVLEVEDI
                     WNIISIGTRYIELVLLFILGYRGEYSNRLVERCYGEVEVVPWN"
     misc_binding    53823..54085
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            54211..55014
                     /locus_tag="KRO40_000461"
     CDS             54211..55014
                     /locus_tag="KRO40_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2091300.1"
                     /translation="MKNILKKVGIFTIMLGLLGGVVGCSKPDNEKDKDASKESKKEVV
                     VGFDNTFVPMGFLDEKGDTVGFDVDLAKETFKRLGMEVKFQPIDWSMKETELNDSKTV
                     DVLWNGYSITDERKKIVSYTEPYLQNKQIIVTLSDSKINSKADLKDKEVGTQQGSTAL
                     DAVEKDKDFMNSLKGGAPVLYDTYDKALRDLEIGRTSAVVGDEVLIRYYMGQKGEDKY
                     KVLKDDFGLEDYVVATSKENPELCEKINETLKEMKKDGTFDKIYDKWFK"
     gene            55052..55663
                     /locus_tag="KRO40_000462"
     CDS             55052..55663
                     /locus_tag="KRO40_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH2091301.1"
                     /translation="MLQGLEIVIAMFCITLIVSIPLGIGVAFLRLSKNKLVSGITQCY
                     ILIMRGTPLLLQMIVIFYGLPLLGIVFDRFTAGVVAFFLNYAAYFAEIFRGGIQSIDR
                     GQYEASKVLGFDKFTMYKRVIFPQVFKRILAPISNEVITLVKDTSLVYILGLNDILRI
                     SQIAMNREASLLPLFEAGAIYLIFVAILTKGFELLEKKYSYYR"
     gene            55695..56366
                     /locus_tag="KRO40_000463"
     CDS             55695..56366
                     /locus_tag="KRO40_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH2091302.1"
                     /translation="MLKIKNLNKSFKKNRVLKDISFELEEGQIGVLLGKSGAGKTTIL
                     RCINGLEEFDSGEIIIDNEVIKNKRDMAKIRGKIGMVFQNFNLFPHMTVLENIIESPV
                     NVFKVPRKEAEERARELLRLVDLEDKLNSYPFELSGGQQQRVAIARSCALMPKVLCFD
                     EPTSALDIDTIQRVVNIMNRLKDKGMTILIITHDVVFSNNVADKIISIKDGIVENVQI
                     KEKIV"
     gene            56664..57026
                     /locus_tag="KRO40_000464"
     CDS             56664..57026
                     /locus_tag="KRO40_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HBH2091303.1"
                     /translation="MIKLYGYTKCSTVKKAKNWLKENNLEFEDIDMVQNPPSKEELKS
                     IYKTSGYDIKKFFNTSGMKYRELGLKDIVKTESDDKLLEILVSDGMLIKRPLLLDGKN
                     VLLGFKEDVWKSTLLKED"
     gene            57462..58163
                     /locus_tag="KRO40_000465"
     CDS             57462..58163
                     /locus_tag="KRO40_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4253 domain-containing protein"
                     /protein_id="HBH2091304.1"
                     /translation="MSIEDLYDFECVPLNNEIDIDVLFEKMIEDGKEKEYTPIIVIDE
                     KVGLLRKNIDMITKEYGSLENYREYCLTKYNEIDVNQFFDFRKSEISELLKELIDLED
                     DFYDYKHFRPIMNIDIFHEYNKVYIAKIPTIKPYEVFAYIPIGGFNDCPRDEEHIAIA
                     KYWYEKHGIFPIAIGCDTVQYSVKNLTKDGKKFDDLCIELVFYCEDIIIQGYETLKAL
                     KDVLKRSTIVLFWWD"
     gene            58433..59251
                     /gene="larE"
                     /locus_tag="KRO40_000466"
     CDS             58433..59251
                     /gene="larE"
                     /locus_tag="KRO40_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent sacrificial sulfur transferase
                     LarE"
                     /protein_id="HBH2091305.1"
                     /translation="MEVNFVKEKEKLDKLKKMLLELGSVVVAYSGGVDSNFLLKVAKD
                     TLGENVIAVTIHAMMHSSREIEEAKQYTQNFGVKHIILNIENFDLKEFKENGVDRCYH
                     CKKYIFSKIKEVAKEHNIKYIVDGTNIDDLGDYRPGLKALSELGVISPLKDSSLKKEE
                     IRSLSKTLGLNTFNKPSFACLASRIPYGVEITDENLRIVEKSEEYLSNLGFSQFRVRM
                     HGDIARIEVGQEELGKFFENNNFNKVDTKLKIFGFKYVTLDMSGYKMGSMNLNV"
     gene            59306..60454
                     /locus_tag="KRO40_000467"
     CDS             59306..60454
                     /locus_tag="KRO40_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HBH2091306.1"
                     /translation="MKNYTLISPCFFGMEKMLAREITNLGYEIIKTEDGRITYKTDEF
                     GIAKSNMWLRCAERVHLKIAEFEAKSFDELFENTKRINWSRYIPYGAQFPISKASSIK
                     SKLYSTPDVQAIVKKAIVESLKKSYLEDGLLKEDKEKYPIFVFIHKDKVTISIDTTGD
                     ALHKRGYREKANKAPIRETLAAGLIYLTPWKAGRVLVDPMCGSGTILIEAAMIGINMA
                     PGLNREFISEKWRTLDKKIWWDVRKDAFNKIDNESKFKIYGYDIDEESIDIARENAEI
                     AGVDEYIEFNVGDATQFKSEDEFGFIITNPPYGERLEDKDSVKQLYKELGYAFRKLKN
                     WSYYLITSYEDFEYEFGQKADKKRKLYNGMLKTNFFQYPGPKPPRNNK"
     gene            60590..61978
                     /locus_tag="KRO40_000468"
     CDS             60590..61978
                     /locus_tag="KRO40_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2091307.1"
                     /translation="MKVLKLITVVALMMLFVTGCNIKTESPEQLAKIPDYDDTKKVLY
                     DGIDQLLKPDSSMILPSNTKEVGKINKVDLNSDGIDELVVFEQKEDLSNNVSQVGFVT
                     LSYNGEKYVLGDHFLENGESIEYANFYDLDSDGYKEVILLVKSKDKTNMHIYKVVDNE
                     ITKIYDLDASWLQNKEDFNDMKVKIGYIDGDDKLDILMLHLNNKTNEMFASVANFDGK
                     MKIKDSVKFENVKNLSELYITLGNVASSVGNSSAAIKGIVLDIPILKDNNYITQILYM
                     KDGKINKAFSDYDKTITKSYYIPVDDIDKDKIIEIPIVAGSTGNNKNTYSSKSSATIS
                     WYRWNGKEGADSSLIFTSQIYYNYKYNFKLFIPNNLFDKILVEQEFVGEKAVFKFYYF
                     DYSDRKNLFNIVVESKNKLEDRKNTGTQNSIVLQESDEYTFLLVVNNANEMDKLDMTI
                     DALKEYFSLIYG"
     gene            62007..62705
                     /locus_tag="KRO40_000469"
     CDS             62007..62705
                     /locus_tag="KRO40_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091308.1"
                     /translation="MKEKILILEDEIGIRSFVSINLKREGYEIVEAGTGREAIEKMTT
                     EKDITIALLDVMLPDISGIEVCKFIRENFDQVGIIMLTAKAQEDDKIEGFISGADDYI
                     IKPFSIKELLVRVSALLRRVAKDDSSVKSSEIVSPPFILDIDKRKLFKNGKEIELTPT
                     EFSIVKYLISNAKQSLSRDQILDEVWGTNYLYDFKIVDVNIRRIRNKIEDDPSKPKYI
                     QTIWGYGYCFRKEE"
     gene            62708..64141
                     /locus_tag="KRO40_000470"
     CDS             62708..64141
                     /locus_tag="KRO40_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091309.1"
                     /translation="MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQ
                     LLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLTKNSEFGISIIDKDKNIILDQYG
                     FKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
                     VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNY
                     NIKLEKMKIVDDEIGDLAQTFEHMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSE
                     TLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRIKLHVDIVDVEGLIV
                     GVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIK
                     VVASQDEEITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHG
                     GRMKIESEKNVGTKITFNIKNKFAKQA"
     gene            64163..64900
                     /gene="truA"
                     /locus_tag="KRO40_000471"
     CDS             64163..64900
                     /gene="truA"
                     /locus_tag="KRO40_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBH2091310.1"
                     /translation="MRNIKMIVAYDGSRYKGYQKLGDNNMTIQEKLENVLSKMTNETV
                     EIIGSGRTDMGAHARGQVVNFRTNCMDSLDKIQKYLYEYLPEDIVVKTVEEVDERFHS
                     RYNVKSKTYMYKIDNNKYHNPFIRKYATHVSKKLDLDRMRKASEYLVGEHDFTSFASS
                     KSKKKSNVREIYSINIKEDDNVIEIYVEGNGFLYNMVRIIVGALIDVGLKRRAPQDIK
                     YMLESKDRCQSSDTAPAKGLCLWKVTY"
     misc_binding    65011..65218
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            65471..66670
                     /locus_tag="KRO40_000472"
     CDS             65471..66670
                     /locus_tag="KRO40_000472"
                     /EC_number="6.3.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
                     /protein_id="HBH2091311.1"
                     /translation="MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKM
                     EDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKL
                     VEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
                     EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEY
                     VEVYFEKGVPKKVNGEELSPVALIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETP
                     GGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQD
                     NVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKI
                     RAMKAGK"
     gene            66917..67963
                     /locus_tag="KRO40_000473"
     CDS             66917..67963
                     /locus_tag="KRO40_000473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4872 domain-containing protein"
                     /protein_id="HBH2091312.1"
                     /translation="MRKIIEIKHHSHDYECMWNGIEDLYINKTGEYLPNDFFFLLSGF
                     GSFCYMKTNKADLKRMVALGDGRTKQMYKFLAPIVGFEYKHHEFKKYEQALKKAKSEI
                     DDGYPVILGALDMYYLPYYKKLYHKEHIPFHYILMVGYDDEGIYLYDCGRTELLHLSY
                     DKLRESMNCNSPGLSKENTICTIRMNTSKNKYNIAREAIAIKRDMFLNPPKGFLGYKG
                     FEKFIKELPQWNTELDKDDYDKILTNMVMFFGTVPTIPNAIKGIKEPDTVQFKGGFDK
                     MSRMLNSIGEEYKNNSFIQVADIFDKTAIIIEKISNIIIDYLTQTCDDTEQLPLLFSE
                     VLEHMKTGYLILDV"
     gene            68071..69234
                     /locus_tag="KRO40_000474"
     CDS             68071..69234
                     /locus_tag="KRO40_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2091313.1"
                     /translation="MRTVKQVSDLTGISVRALHYYDEIGLLKPNKITDAGYRLYDDES
                     IKTLQQILFFKEIDIPLREVKEIMSSQYFDKVEALKNQKKLLILKRKRLDELIELINQ
                     TLRGEGNIDFKEFDMSEYFNVLEEFKREHRNKVIKIYGSVEKYNEYIERVKSNEEKIA
                     KMAIKQYGTIEKFAKAIKTNFSSDILNLGEKFDRYKNDCLKEKHPKLKELYRKLVEDL
                     SRNPSSTDLQEIAKAITDISKKDYEIFSMDTGDDNWYYMVQNYLVNPMWIEEVDKKYG
                     SGAGKFIGQVLKTYLRDRKPKINTLYEKLVEDLSRDCSSREVQSIVEEIDNEMKRSNE
                     FYKIDNGERYFDYMSELYLQDSNYIKVTDKNYGDGASKFIGEAFKIYFDNNNC"
     gene            complement(69323..69703)
                     /locus_tag="KRO40_000475"
     CDS             complement(69323..69703)
                     /locus_tag="KRO40_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4363 family protein"
                     /protein_id="HBH2091314.1"
                     /translation="MKSTTFVILWTILFVLFGFYVNNKLYDFTEGYKDNISVLEKSIE
                     NEDWEKAQKEADSISTSWNKEKNHWYKVLNHEYFDEIGLRFNILDKAIYTENKLKSLE
                     EVESIKTYLGNIIESVKFDVNYIF"
     gene            complement(69706..70365)
                     /locus_tag="KRO40_000476"
     CDS             complement(69706..70365)
                     /locus_tag="KRO40_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HBH2091315.1"
                     /translation="MTVVLIRSIILYITVLIALRVMGKGEIAEMNCFDLVITLLIAEV
                     ASVPMENNNIPIINGVAAISGLVIMQTLISFLSLKSRKLSSFLSGKPSVLIDKGKIVY
                     KELKKERISIDELLEQLRIQGYFNLKDVQYAILETDGNLSVVPASSYNSTPPRAFNHL
                     PIPLILDGRIINKNLDIAQKDTNWLMGILKSNHIETFKDVLICVLDENDKIFIQNKKG
                     D"
     gene            complement(70471..71445)
                     /locus_tag="KRO40_000477"
     CDS             complement(70471..71445)
                     /locus_tag="KRO40_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH2091316.1"
                     /translation="MKYKLFIDFEFNILDDNKNKPKEYNGAELISIGGVLVDNEFNTI
                     DNYYSLVKPKYNKILSNKCKNLTKLNQLDINNAPNLLYVMDDFYKWFCKFDDVTIYNW
                     GDFDITGLLTSFRVYKYTGKCLELFNMMIDIQPFISQHITYNNRILSKQISLLNMKKI
                     FSVEGDIKHNSLSDAVDLMNVCKCFFFNSPKNIDILEELYNKLPALKTPLYYIPYFED
                     ENFELKFDRTPEDIIIYLKQILTILNISKKEIYFKKRSVLVNNSKIINFKNLSSSFKL
                     IKLNEFEEYPDFILKLGDKKSFVESVIKINKSNRKSIKNLILKLSKKP"
     gene            complement(71485..71832)
                     /locus_tag="KRO40_000478"
     CDS             complement(71485..71832)
                     /locus_tag="KRO40_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091317.1"
                     /translation="MLNLKEIREEIIKKYIGDSLISELTEELKNILITDLQSNPFKSN
                     IELSIIPANIEIFKKIENILIDSKVNLKMGWERILINYILKDLFELNYEINKSCNEPL
                     MFRVIISIDSYDA"
     gene            complement(72050..73006)
                     /locus_tag="KRO40_000479"
     CDS             complement(72050..73006)
                     /locus_tag="KRO40_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonine 3-dehydrogenase"
                     /protein_id="HBH2091318.1"
                     /translation="MKKILITGALGQIGSELTIKLRNEYGEQNVIASSRRVKEGNPVC
                     ESGIFEILDVTDKNRFFEIAKKYDVDTIIHLASLLSAVAESKPLEAWNLNMNGLINGL
                     EIAKELDCKFFTPSSIAAFGENSPKNMTPQDTLQRPNTMYGVTKVSGELLCDYYHSKF
                     GVDTRGVRFPGLISYVTPPGGGTTDYAVDIYYEALKNKRYKSYIAEGTKMDMMYMPDA
                     LQSIVDLIEAPADKLIHRNAFNITAMSFSPEEIADSIKKYIPDFVIEYDVDPVRQSIA
                     DSWPNSLDSSSAVKEWNFKFSYDLDKMTKDMLEKLSEKGIGK"
BASE COUNT        29155 a         7557 c        12072 g        24399 t
ORIGIN      
        1 attattacat tattgaatga agaattaaaa tgaagataaa taaaacaaat attggttata
       61 attgattaaa aaatagttat gtatacttgt gactttattt atgggcagtt caagttttat
      121 gaaagaagtc atatatatat ggaatattct aggcagaaac tgtttaataa taagagaata
      181 ctataaaaat ttgagtatta cataaaaaat aagaagccat aaatgatata agcattatct
      241 atagcttctt acttctcatt gattaagatt atatataaaa ataatcacta tattttttgt
      301 ttaagtttta gtacttgttt tactatattt gttgagtggt cagaaattct ttctagatta
      361 gtaagtaagt caagataaag tacaccagca tcaattgtac aacttccatt atttagtcta
      421 atcatatgtg aatttctaaa agttttttct aaataattta cttcattttc aacttctaaa
      481 actttatttg ctaactcaaa atctttaaca tctaaaacta ttaaggcatc cttaaaatta
      541 gtaattgtct tattgtatat ttcgtatatt tctcttatcg cactatcaga aaaactaatg
      601 ttcatttcct taacactcat ggccaattca gctatatttt ctgcatggtc agagactctt
      661 tcaatgtcat ttacagtatt aaaaagcaaa tctgttctaa agcgttcatc atctctaaga
      721 ggttctttag aaagttttaa caaatagttc aatatatctt tctgtaactt attgacaact
      781 ttttctgact caaaagcttt attaatatct tcattgctct tatttaaaaa tcctgcaatt
      841 gaatgttcca aagagtttgt agctttatga cccattctta caacttcttg tacagtatta
      901 ccaagtgcta tagatggagt gctaaacatc ctttcatcta agtacttagt attatttact
      961 atttctgatt cagtttcttt aataggtata agtctatttg ctaatttaac tatgtattta
     1021 gaaaatggta ataatattat aacatttgta agattaaata aagtatgtgc atttgctatt
     1081 tgtctagctg tatcagttgg gtcaaaatga gtaactatgg ctgatatagg tttatttaaa
     1141 acaagcataa atattattgt accaattaca ttaaaactta aatgcattac agctgcacgt
     1201 cgagcatttc tacttgcacc aacacttgat aaaagtgaag taacacaagt acctatatta
     1261 tctccataaa gaataggtaa agcagatgat agaggaagta ttccttgaga agctagtgct
     1321 attaacatac ccatagatgc acttgaactt tgaacaatac cagttatggc aaatcctgcc
     1381 aatataccta atacaggatt tttactaaaa tataaaagtg catcagtgaa tgctttatat
     1441 tcagcaagtg gagctactgc atctttcata aactccattc ctgtaaataa tataccgaaa
     1501 cctataagta tctcagataa atgctttgtt ttttgatttg atgtaaataa atagaataaa
     1561 atacctatac ctaaagcaat tggtgcaatt ccttcaagat taaatgaaac taattgagca
     1621 gtaactgtag tacctatatt tgcccccatt attacaccaa tagcttgact tagattcatt
     1681 atacctgcat ttacaaatcc tacaaccata acagtagtag cacttgaact ttgtataata
     1741 cctgtaacga ctgtacctac cagtacaccc ataacaacat tacttgttaa gagttcaata
     1801 atttttttta atttgtctcc tgctgatttt tgtaaacctt ctcccattaa actcattccg
     1861 taaagaaaaa gtccaagtcc accgataagg ctaattacta tattcacgat atttcctccc
     1921 ttaagaaatt aataattttt ttatctgaat tataaacttt attaactaaa atttattgtt
     1981 tccataatat agaataacaa attttgtcaa taaaaatatt aatgttttgt taagtatacg
     2041 ttaagagaat gttaaatttt taagttgttg ttaattttag aaaatttatg atatatagca
     2101 atttaaatac ttgaacttag atttttagta ttttatgtac aaacaattta acaaagaatt
     2161 aactataatt gtaaaaaata tgtaaaaaaa taacatcctt ttagaatgat attttttagt
     2221 tataaatatt tttatattca attggtgtaa agttattaaa ctttttaaaa attatactat
     2281 agtaattttg actattgaat ccaattagta cagcaacgtc taaaatagac aagtcttttt
     2341 ttaatatata ctttttgctt ttttcaactc taactttatt taaaaaatta gtaaaagtat
     2401 atccactttt tttcttaaac aaagaaaaaa taacttttat taagttgtaa ttcattacat
     2461 atattactta ctgttatatc ttctgagtaa tttttgtgaa tataatttat agttttcttt
     2521 aagttttctt tacataaaac taagagttgg tctatgtttc attttatcaa ggcatattta
     2581 ttaaaaaatc aatctctatt tgttaaaata atttatgaat gatgttagaa actgtaatat
     2641 attggatata atataataaa cagataaact ctgcattaag aggatatata gtttatctta
     2701 attatagggg aagtgaggat atattatgga aagattaatg gaactcatag aaagaaaatt
     2761 tttaaaggat gtagaacttt tagaattaga agacatagaa aatgtaatag aatgcaaaat
     2821 gacacagcca tataatgctc attataatga atatttagta aaagtaaaaa atggagatga
     2881 agtagaagaa tattttgtgt atttaaaaca tagataaaca taaaagaggt ttatatttat
     2941 ttgtatgatt ataaaataaa tacaagcctc tttttttgat aaatataaaa ttataaaatt
     3001 tttatttatt taattttttc aacaacatta gtcaatattg aatctaaatc atcactaatt
     3061 tctgtaactc cattatgagt aatatctata atttctttag tcataggaag ttctcctaaa
     3121 agctctaagt ctaaatcatc taaaaacttt tcagtagatt ctccttcaaa taacttgatt
     3181 tttttagaac aatcaggaca ttggatataa ctcatatttt caataactcc aaggacattt
     3241 atgttcattt ttttagccat attaacagct tttgatacaa tcatagatac caaatcttga
     3301 ggtactgaaa ccataactat tccacttata ggaatagatt gcataactgt taaggcaaca
     3361 tctccagtac caggaggcat atctattaat aaatagtcta attcttccca aagtacatca
     3421 gtataaaatt gctttacaac ccctccaagt aaaggtcctc tccaaacaac aggttcattt
     3481 tcatcatcta tcataaggtt tatagacatt acttttatgt tatttgagtt ttctacaggg
     3541 taaatataag agccatcaga ataagctttt acatttttta cacccataag tctaggaata
     3601 cttggtccag ttatatctga gtctaatata ccaaccttat atcccatttt gtttagctta
     3661 ttagcaagta aagcagttac agttgatttt ccaactccac ccttcccact cataacacca
     3721 attatttttc caaatttatt gttagggtta ttttcaatag aacaatttga ttgactatta
     3781 caatttccct ttgatggaca tgaattacaa tctgccatat ctattacctc caaactttaa
     3841 tatttattag attatttgta acctacatat actattttag tacaattgaa ccataaagtc
     3901 attatttaaa agcaacttag aagattttct attgatttat tcatagacta tagcaaaaag
     3961 aatacaataa aaaaattata acattcttga aaaagtgatt atttcaattt agttatagaa
     4021 cttagtcata taaatatata gaaaatattt taatatatta tacataacgg gttattttat
     4081 aagtttaact ataaattagg tttatatttt ataaaaattt gctaaaaaaa acaattaaaa
     4141 attgtaaaga aaaaagatat aattagaact gtagtaataa atgttttatt atagataata
     4201 gagttttaag tatcttaaat aatatttgga ggaatatgaa tggaattaag accaagaagt
     4261 gcaaaattag aagaatttga taaagtaata gaattaataa actatgtatt tagaatatca
     4321 agaaatcata aaccaactat gatggaagaa tttcctcttt tactaagtaa aaataatata
     4381 gaaaatatga ttataatatc agaagatgat aaagtggttt ctgatgtaaa ctatctaatt
     4441 caggatgtat ctattcaagg aaacagattg aaggttgcag ctataggtgg agtatgtact
     4501 catccagatt atgaaaagag aggctattca tctaagatat tggataaagt agaagaaaaa
     4561 atgttttatg atggtgtaga tattgtaatt atatcaggaa caagaagtct atacagtaga
     4621 agaaattgta gtttggtaaa gagtttttat aaatatacaa taaaacctga agatgtaaaa
     4681 atagcatatg aaatagttga atttgatgaa actaattttg aaaaagataa tgatttagat
     4741 aaaatgattg aactatataa tcaaaatagt actagattta taagaacgag agatgagttt
     4801 caaaaactat tgcatgcagc aactattgcc tggggaccaa ttggttacaa gaaggtattt
     4861 ataaaggaaa ataataatat aataggatat ttgataataa gaacaataaa aaaagaagat
     4921 tctactgtag gagaagttgc tgaaataggg ttaaactctg taaatgttga aaatatattg
     4981 aaatatgttg caaataaatt tggattagaa tctttaaatt ataaagtaca tgtgaaaaat
     5041 cttaaagacc agttgaaatg taatgggaca aaatctttgg attatcaaca aggaactatg
     5101 aaaataataa attttactaa gttgtgtgat agtttaagaa gttattttag tcaatatgta
     5161 gattttgaat tactaaaata catggaattt aaacaagttg aaaataaata tattattaaa
     5221 tacaaagaag aagaacttgt aatagaaaat ttggataagc ttaataaact gttttttgaa
     5281 aaaaatgagg aacagtacaa tgaatttaaa catctaaaaa atatatatga atttgctaca
     5341 aaggcatttc ctgtagattt tccatggact gcaaatttaa attatcaata gttttagatg
     5401 atattaaata aaattgattg atacctagag ttagtccttg ttaaataaga gaaattattg
     5461 gatattgaaa aagcaatttt gtaagtaatt agaaaggatg agtattatat ggacatactt
     5521 gatgatatag cagaatgtat attaaatatg ggtgtagata atatagagaa tttagtaaaa
     5581 attgctatag ataaaaatat tgatgtggaa gatatttatg aatatggttt aaacaaaggt
     5641 atgataggag ctttagataa gtttgagaat aaggaatact atctttcaga agttatagta
     5701 tgcacagatg cattaaataa aggtattaat cttttgaagg gaactggaaa agtaaagaaa
     5761 aaatcaaagg gagtaattct gatgtctgta gtagaaggag atactcatga gataggaaaa
     5821 aatattgtaa aagtaatggt agaagccact ggatataagg ttattgactt aggtgtaaat
     5881 agaaaaagtg aagatataat agaagaagct ataaaaaaca atgtagatat aataggctta
     5941 tcttcaatga tgacaactac aatggaaaat atgaaatcgg ttatagacga acttaatatg
     6001 attgagatag ataaaagacc aaaagtaata attggtggag gacctgtaag tatggagttt
     6061 gcagaagaaa taggagcaga tggatacagt tcaaatgctc caaaagcagt taaattaata
     6121 aataaactta taggaggtga agtttaaatg ttttcagata tgactttact tcagtatata
     6181 aatagtgaag atagaggttt ttttctgcct gatatgggta caaatggatt gttcttaata
     6241 aataaaaagg catatgaagt atatgatagt gtagatttgc aattagaatt agcaaagact
     6301 atggacaagt attttgaatc agattttata tactcattct gtgatgggat tacattttgt
     6361 gaaactctgg gtttagatac attaagacca gattatgatt ttccaagtgt attgacacat
     6421 actataactg acagagataa attaagaaaa ttagatgttc cagaccctta tacgagtgga
     6481 cgtatgccac tcaatataga gagcttatca gttatatcaa aaagtattaa aaaaccacta
     6541 tatgaatcga tacaaggtcc atttacactt gcaggtcaat tagctggagc tactcaactt
     6601 ttaagatgta taataactga taaaaaattt gtagaagaat tattggaatt tacaactgaa
     6661 ttggtaagaa gatatgctgt agctgcaaat aaagcaggag caaaatatat ttcaatagca
     6721 gagccaacat cagtaaccct aagtaaagat agatttgatg aatttatagt aaaaaattta
     6781 aataaaatct acaatgaact tgattgttgg aaaggtatgc atatatgtgg agacaccaga
     6841 gaattattag ataatatgct aagttgtaat atagatgcag taagtttaga ccaaatttta
     6901 gactatgaag aaattgctcc aatgattcct agagatatag ttttgattgg taatttagac
     6961 ccaataaaac ttcttggacg ttctaagcca gataagatta gaagagagac actaaaattg
     7021 ttaaagaaga tgagaagata tgataacttt ttatgtgatt ttggctgtaa ctgcttaaat
     7081 accactccag tagaaaattt acaagcagct ataaaggcag gaagaattag ttataaagaa
     7141 ttagatagga ttgatattga tgaattataa tagtaataaa aataaatatc ttttaaagga
     7201 tataaattta gatgatattt ttatagataa gaatattgtg ctaaagtttt tggggtatgg
     7261 aaatagaaaa gctccagata caattagtaa aatcgttgaa agagaaataa gaaatataaa
     7321 tgatatttta gatatcaaga tatatataag tgaagttgat attaataaaa cacctaaaga
     7381 atgtaaaaaa gcatttgctg tactatatac aataggggat aaaattgatt ttaagatgaa
     7441 tgactatatg gaaaattgca atatgatggc agggctggca ttggataagg taggtatagt
     7501 atgtttagat tgtattaatg agaaaataaa aatgtattta aaaggaaagt atgatagtct
     7561 caaaatatcg catgaaatat atccaggaga taaagatttt gaagtagaga gacaaaagga
     7621 tatttataac tatgtaaaaa ataaatataa tagtatagaa atagaaatta atgattatca
     7681 tcaactatcc cccataaaaa gtgttgcaat gcttatttta atgggggatg aagaaaattt
     7741 agaatcaaga tgtagtaagt gtcctagaaa atgcttttag ttaattttca agactaagat
     7801 ttgttttgtg tataaattgc aataattttt ttggtcattt tatgtataaa ctaaaaaaat
     7861 tattgcaaag taatattcta tttaatttga acagacttac aaactatagt agtttcttta
     7921 attcaataag tgtatttatt tcataagttg gtatatgatt agtataattt atactgttat
     7981 tggaatttaa ccaacaagta tctattcctg aatttattcc acctaagata tcagaggtta
     8041 agctatcccc aattattaag gcagaagatt tatcatgaca attaaacttt ttgagagcgt
     8101 atttaaatat ttcaggattt ggttttgata ttttcaactc ttcagataca accattccat
     8161 caatatattc ttttattttt gaattttcaa gtcttttctt ttgaactgca gaaattccat
     8221 ttgttattat aacaatagta tacttttttt taagatattg taatatatcg attgcacctg
     8281 gaattaaaaa tgtacattca cctaaaaaat ttaagtacat tttgctaaga gtttcagaat
     8341 caacatccaa agatatttta tttgcaaaaa gttcaaatct aagtaattta agttcattca
     8401 aagttataat atttttttca aggtcgagcc aaagcttatc acttatattt ctatatgact
     8461 ctatataatt ctcaaaatta aattctaaat caaactcaga tagaagtttt ttaaaagcat
     8521 gtgattcact tttcttaaaa tcaaataaag tatcatctgc atcaaaaaat ataaatttat
     8581 atgtcttcat ggtttttact cctttacaag atgactgcaa aaattacttt actttcacta
     8641 tttgagtcat tttgccattt atgttttgtt cctaaaggaa cttttacact atctcctttg
     8701 gacaaagtaa attcatcatc atccataaaa agtttaactt ctccctccaa aacatatgca
     8761 atttcatctc cattatgagt aatcctatca acacaagaag aagtgtttgg agctaaatcc
     8821 ataattgcaa attctaaatt accactagag tctggaatta aaatctcata tataacttct
     8881 ttgcttccag gtaaaataac tttttttcta ttatcatgtc ttactatcaa gtttttttta
     8941 tctacctcag atacaaaaaa tgtaaataaa ggaacgttta gagaagaggc tatagatttt
     9001 aatgaattta cagatggatt agcaagacct cgttctattt ggctcaataa tgatggtgta
     9061 acatcagcta gttttgctaa atctcgaata cttaagtttt gtttttttcg aacttcagct
     9121 attttttccc ctaaatttaa atcattcata taaatatcct ctctttttaa tttaaaaaat
     9181 attaacttaa aataatcaag taaaatgatt atgtagtatg aaattattat aacatataga
     9241 attaggtttt gaaaaaacta tgttcaatat aattaaataa attaaaatat aattgacaaa
     9301 gtggatacag aatacttaaa atatatttaa ataaaattaa gcaaaagata gttaatttat
     9361 gataggaggg gatattatgc aaataacgac ttttggagct atatttggtt tattaatagc
     9421 aattatttta attataaaaa aatttcaagc tgtatatagt ttaatgctag gagcatttat
     9481 tggaggatta gttggaggag caaatataac acaaactgta gattttatgg caaatggagc
     9541 tatgaatata tcaccatcaa ttcttagagc tttggcatca ggtgtattag ctggaagttt
     9601 aataaaaaca ggggcagtag ataaaatatc agaacagatt gtaaaaatat ttggtgaaaa
     9661 gagggcttta ttttcgattg ccatttcaac tatggtactt gctggagtag gcgtaaattt
     9721 ggatgtatct ataataactg tagcacctat aggattatat ataggtagaa aattaaatta
     9781 ttctaaattg tcaatactat tagctatgtt gggagggggt aaagcaggta atataatatc
     9841 accaaatcca aatactatag cagtagcaga taatttttct gtcaatctct ctagtgttat
     9901 gatggcaaat ataattccag caattattgg agttgttatt acagttattt tagcaagtat
     9961 attaataaat aaaggaaata aagtacaatc atatgaaatt ttagagcaaa gagaagattt
    10021 accaagttta tttaaatcat tatgtggtcc aattatagct atatttctat tgtttttagg
    10081 aaatgtatct cctatagtta tagacccaat gatagccctt ccaataggag gaatcgtaac
    10141 tctaattgtc acaggaaact tgaacaattc aagagaatat ttagcttttg gattatctaa
    10201 gatgcaaggg gtatgcatat tattacttgg aacagggact atcgcaggaa ttatacagat
    10261 gtctgaatta caacagagta caataggtgc tttacaattt ttaaatatgc cacaattttt
    10321 attggcacca gtttcgggta tacttatgtc attagcaaca gcatcatcaa cagctggtgc
    10381 tactatagca tcatctactt ttcatgatgc tataataaat ggtgggctat caccgatttc
    10441 aggtgcctca atagtaaatg ctgggtctag tgtattcgag caattaccac atggctcact
    10501 atttcatact agtgcaggta gtataaacat ggatataggt gaaagattta agttaattcc
    10561 atatgaagca ttgataggaa tagtaatgac tataatttca acatctattc aattagtttt
    10621 ataataaata taaatattta atgaaaaaag taggattttg ttattaaata ttgaatttat
    10681 tatagtaaaa aagaagattg gagttttaaa gtgaataaaa aaaagattgt tattataggg
    10741 attatttatt catttttagt agtattttca cttacaaata tgtatgtaaa tatggagtat
    10801 aatctaaatg tatttgaata tattaagaag tcacttccat ttacagaaga agaaaaaaag
    10861 tggttagaaa aacacaagaa tttgatttac agctctgacc aaagttcacc tcctttgaga
    10921 tataaaggta aggaagatgg acagtataag ggaattattg ttgatttaat aaattctctg
    10981 tcaattcaaa ttggtagaga tttttatttt aaaccaaata attggtggaa agaatctttc
    11041 gtaaattcaa tagatgatag tataaagttt tttgacttga ttccatcaaa agaaagggca
    11101 aataaattta tatttactga cccaatatac actttgagtg caaatatatt gaaagataaa
    11161 aagtcccaag atataaatag ttacatggat ttaaagggga aaacagtagc aattccagaa
    11221 ggtgattatt ctataaattt tttaaagcaa aaaattcaag atataaacat tttgttgact
    11281 ccagatataa agactggagt caaccattta atgtctggaa aagtagacgc agttgttggt
    11341 gatgaaccag tattgcgata ctatataaat aattatggac tttcaaataa atacagtgtt
    11401 ttaagtaatc ctatatatac taaaaaagca gttcttgctg tacctaaaca atatgaagag
    11461 ctggttagta ttttaaataa aggcattttt aaacttcaga aaaatggagt gtataaagat
    11521 ttaaagaaaa aatggtattc tacgtataat gaagttgatg atatattgta tgagcgagga
    11581 attgtgccta gtatttatct ttttataggt ataattttaa tatcaattta tgttttttat
    11641 agctatacat atttgttaaa gatagaaatc aaaaggaaaa cagaacaggt aatagaaaat
    11701 aaaaaaactt tagaggcaac ttttaatagt attacagata taataatgct tgtagatgaa
    11761 aataacaata tagtagaatc gaacaaagta ctatatgact ttatgggtga aatgagttat
    11821 aagatagcag atttgattag catgataaaa ggtgttattg aaaatacctt ctctgaaaat
    11881 actaataaaa ctagtgaaat agaaatacac aataaaattt taaagataaa cacttttcct
    11941 gtagagtata aaaaaaataa tactgagtat atagtagttc ttattaaaga tataactaat
    12001 gataaaatag tagaggcgaa attacttaga gaaaacaaaa tgatatctat aggacaatta
    12061 gcttctgggg tagcacatga gataagaaat cctttgggta taataagaaa taattgctat
    12121 ctcttaaaag ataacgttac aatggaagaa gtaaatgatt gtgttaaatc aatagaaagt
    12181 aatgtagata gggcaagtaa tataataacc aacttgttaa atttcgcaag aatatcagat
    12241 gataatttag aacatataaa tataagaaat tttattgaaa atatagtgaa acttcaatat
    12301 aaaatgttac agttaaagaa tgttgaaata aaaattgact gtgaacataa tttagtatgc
    12361 tatataaatg gagaatcgtt aaaacatgta tttataaatt taatttctaa ttcaatagat
    12421 gcaatacatc aagatggaaa aattattata tactgttatg aaaaaaatta ttgtttattt
    12481 atagatttta aagataatgg tgaaggaata aaagaagatg ccctaaagga catatttaat
    12541 cccttctata caacaaaacc aattggtgag ggaactggtt taggtttata cattacttat
    12601 aatgagatta aaaagaataa tggagatata agtgttgaaa gtaaattggg ggttggaact
    12661 tgttttcata taaaaattcc attaaataaa gaggtgacta tataatgaaa atactattag
    12721 ttgatgatga gctagaatat ggagtggtaa tgaaaaaaat tctacaaaag aagggctatc
    12781 ttgtagatat agcactaagt ggtgaagaag ctataaatat aattaaaaaa gataaaaatt
    12841 atgatttggt tttgtctgat gttatgatga aaaatatgga tggagtacag ctattagata
    12901 gaattaaatc tattaataga gatatagagg ttatattagt tacaggatat ggaagtattg
    12961 aaaatgcagt tgatgctatg aaaagaggag ctttatctta ttttataaaa agtaatccca
    13021 ttgaaaattt attagaagaa gttgaaaagg taaaggcaag taaaatatct gtttctgtac
    13081 aaaaaaataa tctggaattt actttggaat ctaaaaatag agattttaat aatatcataa
    13141 aaatagcaaa aaaagctgct tgtaaagatg ttaatatatt aatcttgggg gaatctggtg
    13201 taggaaaaga tatattagct agatatatac atagcataag tccaagaaag aatgagatat
    13261 ttgtacctgt aaattgttgt tctttttcag aaaatctatt ggagtctgag ttgtttggtc
    13321 atgaaaaagg ttcttttaca ggagcagtag atagtagaaa aggtagattt gaactttcga
    13381 ataaaggaac tctatttttg gatgaaatag gagatatacc tctaaatgtt caggtaaaac
    13441 ttttgaggac acttgaggac aaatctatag agaggatagg aagtaataaa tctattaaag
    13501 ttgactttag gttaatttgt gctatgaata aagaaccaaa agtggaaata tcaaatggaa
    13561 atataagaga agattttttt tatagaataa gtacaataac aataactata ccaccgctaa
    13621 gaaagagaag agaagactta actactctta tagaattttt cttaaataag taccaaattg
    13681 aacatgataa aaagatacac tcgattgata aggaagtaaa ggatttttta ttaaattaca
    13741 attatccagg aaatataaga gaattaaaaa atataataaa tagacttgta gttttaagtg
    13801 aagaaggcaa tttatcaaaa gacaatttaa atttaatatc aaataatgta tacatagatg
    13861 ataaaataag tattagacct ttaagagaaa taagaaaaga gtttgaatgt gagtatattg
    13921 aaaaagtttt atctttgtgt ggaaataata tttcaaatac agctaaaaaa ttggagatta
    13981 gtagaagaca gttaaccaat aaaatatcag agtataatat taagtgagaa aaaaacttct
    14041 cattaagtga gaaaaaaatt tctcaaactg tattaaaaga taaacagaaa aaatctgttt
    14101 atcttttttt attataattt taaaaattaa tatttacaat aattattgct aaattcaata
    14161 ttggtgtaaa ttaaaaatga aaatttctat gacattaata catagaatat atattttaaa
    14221 taattggcat agaaaatgct ttatatatta ataaacgtaa taaatacttt taattgcgat
    14281 taaatatatt aagggggatt ttcatatgaa gctagagcta gggaatatat ttataaaaaa
    14341 tgttgaattt ggagaaaaga cagaagtaaa agatggagta ctatatatta gtagcgaaga
    14401 aatagaaaag atagtattag aagatgaaag gattgtaagt gtaaatgttg aacttgcaag
    14461 acctggcgaa tcaataagaa tagctccagt taaagatgta atagagccta gagttaaaat
    14521 tggagatgaa agcaaaatat ttcctggaat tataaataaa gtgaagactg taggaagtgg
    14581 aagaacccat gtacttttag gagcttgtgt tgtaacttgt ggaaatatag ttggatttca
    14641 agaaggcgta attgatatga gtggtcctac tgctaaatat acaccttttt caaaaacaaa
    14701 taatatatgt attgttataa aagcaaagga tggtatagat actcatgatt atgaagaagc
    14761 agctagaatt gcaggattaa aaataggtgc atatgtaggt gaggcaggaa gagaagttga
    14821 gccagatgaa gtcattgtat atgagacaaa gccattatta aaacaagtaa aagaatatcc
    14881 agacctgcca acagtagcat atgttcacat gttacaatca caaggacttt tacatgacac
    14941 ttattactat ggggtggatg ctaaacagat agtgcctaca tttatgtatc caactgaaat
    15001 aatggatgga gctataatat ctggaaactg tgtagcacca tgtgataagg ttacaacatt
    15061 ccatcattta aataatccag ttatacatga cttatataaa agacatggaa aagatttaaa
    15121 ctttatagga gttattttga ctaatgagaa cgtattctta gtcgataaag agagaagctc
    15181 tgatatggta gctaaattaa tagaattttt aggagttgat ggagttctag tgacagaaga
    15241 aggttatggg aatccagata ctgacctaat gatgaattgt agaaaatgta gtgaagttgg
    15301 agcaaatgta gttttgataa cggatgaatt tcctggaaaa gatggcaaga gtcaatctat
    15361 agcagacgct actaaggaag cagatgcagt tgtttcttgt ggtcaaggaa atctagtggt
    15421 tcatttccca gcaatggaaa aaattatagg aactttagat tatgttgaaa tgatgatagg
    15481 tgggtataaa ggatgcttaa atgaagacgg aagcatggat gcagagctac aaattataat
    15541 agcatcaact atagcaaatg gctataatca tttgacagca agatattatt aaataagtat
    15601 ttgaatataa agttctgttg atataatcat tggtctaatt gatgtaacaa ctataaagtg
    15661 atttggagga ttaagagatg agtaaaatca gagtggttca ttatataaac aatttctttg
    15721 ctggtatagg tggagaggaa aaagcagata ttccgccaga aaaaagggct ggtgtagtag
    15781 gacctggaat agcatttcag agtcaattta atgatgatgc agagataatc tcaactgtaa
    15841 tttgcggaga tacgtatttt ggtgaaaata ttgagagtgc aactcaagaa cttttaaaaa
    15901 tgataaaaga agaaagccct gatttattta ttgcaggccc agcatttaat gcaggtagat
    15961 atggagtagc ttgtgggact atttgtaagg cagttgaaga agagttaaat attcctgtaa
    16021 ttacaggcat gtataaagaa aatccaggtg tagatatgtt taaattagat ttgcatatag
    16081 tgtctacagg aaattcagca gcaagtctta gaaaggtagt tccaataatg acaaaactag
    16141 gtcttaaatt ggttagaggt gaggaaatag gacctcctga agaggaagga tatataatga
    16201 gaggaataag aaaaaatttc ttccatgaac ttagagggtc tgaaagagca attgatatgt
    16261 tggttaaaaa gatgaaaggg gaaagctttg aaactgagta tccaatgcct gaatttgata
    16321 gagttacacc tatgaaacct gttaaagatt tatctaagat aaaacttgcc ctagtaactt
    16381 ctggagggat agttccaatt gataatccag acaaaattga atcttcaagt gctactaaat
    16441 atggaattta cgatttaaca gatatggatt ctatgtcaaa taaagaattt acaactatac
    16501 atggggggta tgacagagca tatgtccttg aaaatccaaa tttagttgta ccactagatg
    16561 tagttagaga gcttgaaaaa gaaggtgtaa ttggagaatt agtagattat tttataacta
    16621 ctacaggaac aggaacgagt gttggcaatt ctaagagatt tggagaagag ttttctaaaa
    16681 aattgttaga agatgatgta gatgctgtaa ttttaacttc tacatgaggt acttgtactc
    16741 gttgtggagc aacgatggta aaagagattg agagagctgg tatagcagtt gttcatatat
    16801 gtacagtagt accaatatca cttacaatag gagctaatag aattgttcca gcagtaggga
    16861 taccatatcc acttggaaat cctatgttag gagaagagga aagtaaaaaa attagaaaga
    16921 atatagtttt aaaagcttta aatgcactaa cagaagatat agaagaacaa acagtatttg
    16981 aataataaaa atacaacaca acactgaaat aaaaaaagat atcaaaaaat aattttttaa
    17041 aattatttta cgatatcttt tttttattag gtaaattcga aatttgcatt ttttaaaatt
    17101 aaatttataa aagtgataaa ttagtttatt ataatattga tacacaaatt caaattagat
    17161 atactatgaa aagcgagatt attacatttt ggaacaaata ttcaacatat tagatcatat
    17221 taattgaaca gaaaaaatta actttatata ataattagaa taatgataag aaagaaggtg
    17281 tatatattga tttcaattgc catttgtgat gatgaatcct atatgctaaa tcatttaaag
    17341 gaaaatatag aattatacat gaagcagaag aatttattat ataatataga gctttttaat
    17401 aaagtagaag atttactatg caatcatgaa aagtttaata ttgtattttt agatatacag
    17461 atggaagaga ttaacggaat gcaggcagct agaaaattaa ggtcatatgg taatgagtgc
    17521 tttataattt tcgttacagt tttaaatgaa tttgtatttg atgcttttga agtagatgct
    17581 ataaattatc tgataaaacc tctatctaat gagaaactat ataaaacttt ggataaaata
    17641 gttacaaaac ttgatgataa tgaaagtaat tatatcacaa tacaaaaagg ttattcatat
    17701 tggaaattaa aacttgctga tattttatat tgtgaagtta taaaaagaaa gatttatgtt
    17761 catttaaaga aagagactgt agattattat gagactattg aaaatttaga gagaagttta
    17821 ccaacaaatt tttttaggtg tcatcgtagt tatataatca atttacaata tgtatatgga
    17881 tatgaaaatg gtaatgcagt tatggaaagt ggagatagaa tacctgtttc tagactacgt
    17941 caacaaatat tttcaaaagt tatgcttgag ttcatgaaaa ataggaggat ataagatgat
    18001 taatttattt tcttccgatt tatttttaaa gtacagtttt ttattttctt ttattgtata
    18061 tagaatttta atggtaatag tgcaatacta ttttctaatc agttttacaa atgttaattc
    18121 aaaattttgg tgttttattt tatattcgat aatttcaatt tttttaatca ttataaatac
    18181 atattttaat ttatataatt tattttcttc acagattcta ttttttctta tgactttttt
    18241 atttgtaaag tacataataa aacaatctac tgttttatct atagtatcaa ctttgttagt
    18301 atatttaatt gaacaattag tatatggatt tacagctcca ttaaattact tgatatttac
    18361 tagtgatata aatacagata tttataaatt tgatataaat atgggactat cttctttaat
    18421 tactattata atagctggat ttatatattg gtatagttct aaaaagttta atattaaggt
    18481 catgaacttt gataaatata tagcaatttt gatgattcca ttgttgctta taatattatt
    18541 tatgcaatca tttgaatata gttcaaatat aaatatagat acaagtcttg ggattgtaaa
    18601 gctgctatta aatacttcta taactgaaga aattcaagct tttctttttt ctataattgg
    18661 aactatatgt gtattttttt ctctatttac ctttaagaaa ctaattcaag ctctcgaaga
    18721 tgacaaggag agggcaatta tgaatcaaca gattcatgct caaaaaaact atattgaaga
    18781 agcgaaatca cgattatcac aaactatatc ctttagacat gattttaata atcatttagc
    18841 tattgtcaat ggattgttga aaaaagacca aattttaaaa gcacaagatt atttaaataa
    18901 gcttgaaaaa gtaacaagtg acctatcatt ttcttgtaat acacagaata ttgttattga
    18961 tgctcttttc aacaataaat taagtatagc aaaacaatta ggcatagagg tagattgtga
    19021 agtaattata ccccaaagca ctaacatgaa cgattttgac ctatgtatag tgtttgctaa
    19081 tgctattgac aatgcaatta aagcttgtag agttgtagat aaacaaaata ggtatttaaa
    19141 gctttccact aagttagagg gtggattttt tatgatagaa ataaaaaata gctataatcc
    19201 aataaataat tatacaagtg gctcaggtat aggtctttta aatataaaag aaattgctaa
    19261 aaaatatcaa ggggctataa gtatagataa gacatcagat tattttcaaa taaatgtatt
    19321 gctggttatt tcattacatt gcgctagtat ttgataacaa tttcattgaa aatagtattt
    19381 gtaagctata ttatgtactt gaatagagaa agtttgatat atagaaatga ggaggttact
    19441 aaaatgaaag ttggaaatat aaatggtcaa gcaccaatta caaatggttt agatagttgt
    19501 caaagtgagg tacaaggctt agaacaaaag aaaaaatcat tacaggatga aatagagaaa
    19561 gtaagaagtg ataaaagtat tgatggtgaa acagccaaat taaaaataga agctttaaaa
    19621 aaagaaatgg aagagattga aaataaaatt caagagttaa aaggaaataa agcaaaaaaa
    19681 acaaataaag aagaaaataa tgtttcagaa gtaaataata atctattaga gagaaaaaaa
    19741 gaaccttcta ataatgaaaa tgtaaaacaa ttatatgatg tttttgaaag aagcaatgta
    19801 gacgaacaat gggataatac ttatcgtgtt ctccaagatg ataaaaactt aaaagtaaaa
    19861 tttaatagac ctatatagtt tatttataaa aatagttaat attttaatta tcaccacttt
    19921 ttagaagaat acacacttta ttttaaagac ccacatattt atttacagtt agcacattta
    19981 tatgtggttt tataactatt atttacaagt ctatattgat aacttttaca tagtatataa
    20041 tgtttaaata cttattcaaa tttatctata cataaacaaa aaaagagatt ttaaaatctc
    20101 tttttagatt gttgacttat ggctttttga tttaataaaa tcaagaagcc gtttgaattt
    20161 tatctgttgg ctgataccct tctgatattg aaacaccatt tttgtttcca aaatcgttta
    20221 aaattaagaa cttattatga atgactattt cattatgaac aataagcaga taacatgaat
    20281 cttcaatcaa tgttttaaca gtagcattaa atgcttgctt atacagttct atcgtttgtt
    20341 tgaactgtcc attaaagtaa atatgagtca ataacataac tatatctaca caaattaata
    20401 taaatttttt atactgtaca ttatctaact gttgattatc tgtattacaa catgattgaa
    20461 tttaaaaagc catcaacaca tagaatgttg atggcctgaa aatagattta aaatctcttt
    20521 tttattatat attaattatt ttttaaattt atattttttg catcagattt tctaatagct
    20581 aagtcaaacc ctctaaatct aatcactata gggtcattaa gaggagctat ctttttcact
    20641 tcaacttcag tgccatctat tagtcctaag gctagaagtc tcttcataag tttttcattt
    20701 ccagctatat tgtctataat tcccttttgt ccaagtttta agttgtaaac agtcattatt
    20761 aacacctcct aatgaaaatc attatcaaac tttatattta taatatataa caaaaagagc
    20821 aaattgtcaa tatataacaa aaaataaaca tactaagtta gtatgtttat aaaaaatagt
    20881 atacatggga tactaatagc atctagcaaa aaaccactta ctaatggtac aactaaaaag
    20941 gcttttggag aatcaccata tttttgtgtc aaagaactca tatttgccag agcgtttgga
    21001 gtagctccta ttccatgtcc aatcaaacca cttattatga tggcagaatc aaaatctttt
    21061 ccaagtactc taaagcaaat aaatattgaa aataggatta taaagattac ttgaaaagtt
    21121 actattaaga gaataggagg taataatgta gataattcaa ataaatctat attcataagt
    21181 gataaagtta aaaaaattcc caatgaaagt tcttttaaaa aatctataag tttaaaattt
    21241 aattctagta tatttatctt atcatttaaa tttctaaaaa taacagccga aaacatacaa
    21301 gttacaacag agggtaatag tatattaaac gttatataga agcatctact tataatttct
    21361 cctgtattta tacaaataaa tatgagaaga acctgttcca aaaatacaga tggtgttatt
    21421 gtttcggaga agttattatt ttttatccta ttcttatttc taaaaaattt acttccaaat
    21481 ctctttagat ttctattata tctaggaatc gacaagtcta tatttgatga tggttttaat
    21541 ttatatttat ttattagaaa tttagctaca ggacatccca atataccacc cataataagt
    21601 cctattgttg cagcagataa tccaacccca actgctcctt ctataccgag attttctatt
    21661 gtaagtccaa atgcagcaga ataaccatga ccaccttcca tagatacatt tccacacata
    21721 agccctaaaa gaggttcaag ttttataatc tttgatattg taatagctaa tatattttga
    21781 caaaatgcca atactccaca caaaatccaa tatctaaata atacactacc acctttcttt
    21841 ataagattta tgcttatttc aagtcctata gttgtaaaaa agaaggttat gaaatttggc
    21901 attaaatttc cacttataga tatatctgct atattaaaat atttaaaaaa taaatttaga
    21961 aaacaaaata atagacctcc tattactggt gcaggtatac agaaattatt taaaaagtta
    22021 actttattct tcaataaatt accaattaaa aagaagaata tagatagtgt caaggtttgc
    22081 actatatcaa aacttaaggt aatcaaaata agtcctcctt tgtaattcaa agttttaatt
    22141 atataactta aattcttatg tattgaaatt ttattatcaa atgtatatta ataaatgtat
    22201 attaaaaaga atcagtagat ataattagat agtcataaat taaattaaaa tattttaatg
    22261 agatatgact tttttagaat taaaaaccgt agtatattga tataatagaa ataagactta
    22321 aaaatctgtt gatagtatta tttataagta cagtaggagg ataaaatgtt tgaaaattta
    22381 cctaagatag atttacattg ccacttagat ggaagtgtta gagtagaaac catgcttgat
    22441 atagctatta aagagaaaat agatttacct tcaaataata tggatgaaat aaaaaaatta
    22501 gcaaaggttt cttttaattg tacttcacta gatgaatatt tagaaaaatt tgatttaccc
    22561 ttaaaagtaa tgcaatctaa ggaaaattta aaaagaatta cttttgaact tttggaagat
    22621 gcaagtagag aaaatgtaaa atatattgaa attagatttg caccattact tcacacccaa
    22681 aaaggtatga gtgttaaaaa tataattgag ggtataattg aaggaattag agaagctgaa
    22741 agtatttatg atataaaagg caatttaata ttaggttgta tgagaacaat gacctcaaaa
    22801 gaggcattat tagtaattga agaagggaaa tcatttgtaa ataaaggtgt tgtagcagta
    22861 gacttgtgtg gtccagagaa agagggattt tgtaaggaat ataaagatgt ttttaaatta
    22921 gcaagagaat atggatataa agttacaata catgcaggag aagctgcaag tggagaaaat
    22981 gtattggatg ctataaatat tttaaaggcg gataggattg gtcatggggt aaaaattaaa
    23041 gaccataaaa aggcgtataa tttagttaaa gataaaaaaa tattgcttga attatgtcca
    23101 actagtaatg tacaaactaa gacagtagat tcttatgaag cacatccatt ttatactttt
    23161 tataaagata atttacatgt aagtataaat actgataata gaactgtatc agatataaat
    23221 ttaagttcag aactaaatgt tatatttgat acttttaaac taggattaga agactataaa
    23281 ataatttata gaaatgcagt agaagctagt tttgcagata aagaaactaa agagtatttg
    23341 aatagtttaa tttaatagat aaaaatattt aaactttaaa ttaagctatt aaattgataa
    23401 aaatacattg tattaggaga aaaaatgtga aagattatga agatgttgtt tatattaaac
    23461 tagtcaaaaa agaacttgaa gaatggaaga aaaatatatt aaagaaacct tctatatttg
    23521 acaaagcatc aaagggtata cagaataaat ttaatggagt attgccagat aaatatcatg
    23581 aaataattac ttcttctata aaagtaatga caaaaaccgt actgtttgga tataaatatg
    23641 ctacaaagcc accacttaga aatatgtcat tagaagaaag agaaaaatta gttttagaaa
    23701 aagctaaaac ttacaagact acagcaatga ttgaaggggc aggaacaggg gcaggaggaa
    23761 tcctcttagg tttatctgat tttcctttgc ttttaggtat taaagtgaaa tttttatatg
    23821 atgtagcttc aatatatgga tatgatgtta aagattatag agaaaggatt tatatattaa
    23881 atatattaca gttggctttt tctagtcaac agcatataaa caaaactttt aaattgatga
    23941 ataactggga tgaatatgta aatagtctac cagaagacat caatgatttt gattggagaa
    24001 catttcaaca agagtatagg gattatttag atttagctaa gtttttacaa ctaatgcctg
    24061 gaataggagc atttgtagga ttttatgtga atggaaaatt aattgataaa ttatgtgaaa
    24121 ctgctgtgtc tgcttataga ttgaggattc gagagcttaa gttataagaa aaattataac
    24181 ataaaaaatt agttatacaa tatatctata tgtatctaat tttgcattga taaaaacaat
    24241 tatggataaa aggtaaagca tgatagaatc taatgtagag gtttgtattt taatggaaaa
    24301 atttagtttt tattgcttaa gatacaaatt gaattacgaa gagattgaat tatgaagaga
    24361 agtaattggg aggaatattt tcatgacaaa tttgccaaaa caatttgata gcttcaatga
    24421 agctagacaa aaaggattta taaatgcaaa ggaacttaag gaaagtggga aaaagatggt
    24481 tggagttttc tgtacattta ctccagttga aattccaatg gcagctggag caactgtagt
    24541 aggtgtatgc ggcgttagtg aagagccaat acctgatgca gaaagggtgc ttccaagaaa
    24601 tctttgtcct ttaattaaat caagctatgg acatgcaata acagatacct gtccttattt
    24661 ctatttttct gatttgttga taggagaaac cacttgtgat ggtaagaaaa aaatgtatga
    24721 agaacttgca aaagttaagc caacatatgt aatgcatttg ccaaatactt caaaaggaga
    24781 atttgcctat aaactttgga aagatgaaat gataagatta aaagaagagg ttgagaaatc
    24841 tttaggtgta actataactg aagaagatat aagaactgct ataaaagata aaaatgaaga
    24901 aagagaactt ttaaaagagt tttatgcact tggtaaatta caaccatctg cacttacagg
    24961 ccttgagtta cataatgttt tatatcaagc aggttttaaa tttgaccgtg cagaacttaa
    25021 acattcttta agaaaagtta tagatgatat gaaagaaaga tatgaaaaag gtgaatgtcc
    25081 tgttcaaaaa gataagccaa gaatattgat aacaggttct cctattggtg gaataagcga
    25141 aaaaatagtt aaaactttag aagatgcagg ggcatcagtc gttgcatatg aactttgtgg
    25201 agctattaga tcaaacgatt tattggttga tgaagaaata gaagatgtat atgatgcttt
    25261 aacacaaaaa tatataaata taggttgttc ttgtatgatg aataatgaca atcgtattga
    25321 attattagat agaataatag atgaatataa tgtagatgct gtaatagatg tagttttaca
    25381 agcatgtcat acatttaata tagaaagtta tagaataaga gaatttgtta caaaagaaaa
    25441 aaataagcca tttatgtctc ttgaaactga ttattcaaaa tcagatactg aacaattaag
    25501 aactagattt gaagcgtttg tagagatgtt gtaggaataa ataaaagtag gaggaactat
    25561 gtttagtata ggagttgact cagggtcagt ggcaacaaag ggtgtgctat ttgatggtga
    25621 aaaaattatt aagaaaataa ttataccaac tggatggagc cctaaaagta catctaaaca
    25681 ggtctatgag ttgctaagta gtgaaattga caaaaaagat ataaaaaagg tggtaggtac
    25741 aggttatgga aggggagtaa tggattttgc tgataagaaa gtaacagaaa taacttgtca
    25801 tactagaggt atttactttt taaacaagaa cataaggact attttagatg taggtggtca
    25861 agatagtaaa gttataaatt tagatagaga tggaaatgta tttaacttta taatgaatga
    25921 taagtgtgct gcaggaactg gtcgattttt agagattact tctaaccttt taggaagcga
    25981 tattgaaagt atagatacat tagctaaagg atatgaacca gttaatatat ctagtatgtg
    26041 tacagttttt gctgagtctg aaattgtaag tcttctagct caaaacattt ctactggaga
    26101 ggtagcagca gggatactta aatctattgc aaataaatcc acctcaatgt tagcaagagg
    26161 tgaggtaata gatgaagttg catttactgg agggcttgca aaaagtaaag aactagtaaa
    26221 aatgatagaa gaaatactgg gtaaaaaaat ttttattgca gaagatactc aaataatagg
    26281 agctttagga gctgctgtaa taggatttag ataaaaacat ataaaaagaa aatgagaagc
    26341 tgaatttatt ataaataaat tcagtttttt attttatttt atttatttat aaaggaaaac
    26401 tttggtataa ttgatttaaa tgattgtata tttgtaaata cttgatattt agtcatatat
    26461 aacattataa ttttaaaaat tagctcaaaa taagggggag aaagcgtgaa aaaatttact
    26521 tcaaaaaaag taacaaggtt tgttgcgctg tttttaatat ctattttagt aatgtcaaca
    26581 attcctgtat cagctgacaa tagcaataca ttgaatcaga taaaaaaagc agaatacagt
    26641 gagacgtata aacaatatct aaatgatgct aaaaatggat gtacagaaaa atataatggg
    26701 attataccaa atccatatca gttggaaggt actcaaatcc aaagtaaagg aagaacagct
    26761 ccaacatctt atgaccctag aaaattaggt cttatgacat caataaaaaa tcaagaggat
    26821 ttaggaatct gttgggattt tgctgcaatg gcaaccttag aaagtttctt aaagttaaat
    26881 aattatggag actatgattt atcagaagaa cacttaagat ggtgggcttc agatggtgaa
    26941 tatggatggt ctgtaaatga tatgaatggt gctttaaatt atgaagctat gggatattta
    27001 acatcttggt caggtcctaa attagaaaaa gatatcccat acaatggtag agtatctaaa
    27061 gcacaaggag caaaaaaacc aactaatatg aatacagcac ctactgtttt taatgtgaca
    27121 gatgctgtgt gtgtaagcaa tgacataaat tctacaaaaa atgctatatt acagtatgga
    27181 gctgtaacat ctggttatta tgaagatatt aaatatcaaa gtgatgacca aaattcatat
    27241 tattgtccaa caaaaagttt taatacaaat catgctattt caattgtagg ttgggatgat
    27301 aactattcta aagataattt taatgcaaat attagaccat caaaaaatgg tgcttggtta
    27361 ataaaaaata gctggggaga ttataattct gagggtggat atttctggat atcttatgaa
    27421 gacaagacac ttatgtctga tatagataat ttttcaatca aaggtggtaa aaaaccaaat
    27481 gatgatgaga agatgtatca acatgactat gcaagtattg tacctttaat ttcaaaaaag
    27541 ataacagctg caaatgtatt tgatttcaat agaggcgatg aaactctaaa atctgtaatg
    27601 ttcttaactg aaagtatagg agctaagtat gaagtatatt atgctccagt agtaaatggt
    27661 atacctcaag aaaacaatat gaaaaaatta aaagaaggta ctgcccaata ttcaggatac
    27721 ataacagttc caattgattc ttttgatata ccagaaggaa agggtgcaat tgtagtcagt
    27781 atagagggga aaaatggaga gtcaactata ggttctgagt caaatgtacc aggatatgat
    27841 acatttaaag caaaagctaa tttaggtgaa agttatatca tagataatac tggaaaattc
    27901 tttgatataa atagagatag taacttctat ccgtgtaatt ttactataaa agctgttaca
    27961 gaaaagtctt ctggtgagag tatcccaaat gagtctttaa ttggtagtga tagatatgaa
    28021 actgctatca aagttagtca aaatggtttc aattcttcag aaaatgtagt tttagtaaat
    28081 ggcagttcaa tagtagatgc attggcagca actcctttta catctgctat aaattcacca
    28141 atattattga cacaaaaaga agctttaaat tcaaaaacta aagctgagat acagagatta
    28201 ggtgctaaga aagtatacct aataggtgga gaaaattcta taagtaaaga aattgaacaa
    28261 caattaaaaa gcttaaatat atcgatagag agaatatcag gaagtgatag atacaagaca
    28321 agtttattat tagctcaaaa gttaaatggt ataaaaaatg tatctcaaat agcagttgta
    28381 aatggagtga aaggattagc tgatgcaatt agtgtaggcg ctgcagcagc agaaaataac
    28441 ataccaatca tacttgcaaa tgaaaagagc gaattgcaag gagctgatga atttctaaat
    28501 tcattaaata tagagaaatc ttatattatt ggaggaacag catccctatc aaacaatcta
    28561 gaaagtaagt taaaaaatcc aactagatta tctggtagta gtagagacga aactaattca
    28621 aagataatag ataattttta taaaaaagat actttaaaaa atgcatttgt agttaaaaat
    28681 ggaatcaaga atcaaaatga tttaatagat ggattggcag ttggtccttt aggagcaaaa
    28741 actgggtcac cagtaatttt agttggtgat aaattagctg atagccaaaa agaagttctt
    28801 aaaaataaga ctttagaaaa agtaactcaa gttggtggag gagcaaataa aaatgcattt
    28861 aaagagttag taaaattaaa aagtgctaaa tagagtactt aagtattaac atatattagt
    28921 gtgtattagt aacttatctt aataaaagct gaaaataatt acttcaaatt attgataaat
    28981 aagataatca atgattgtaa agttttgttt tcagctttaa atttatgtag tataagttta
    29041 aaaacataaa aaagggttac tttatataga aatatagaaa atcttacatt ttatatataa
    29101 ataacccata tttaattaac tttttatagt gttctaatag atattattga acttaatggt
    29161 aaatataatg tgtaagtttc atttaaagtt ggattagatt catctatata tcttgagcaa
    29221 agtgtaattg ataagctatc tgcttctata atttcaccat atagaggaca actgctaaag
    29281 taagaatgta cttcaacata tttatttaag ttttcttgaa cataatcgta aaaacggttt
    29341 tttgtagtag tagccataaa atcaactcct ttatttttta ttaaagttga aacttttaaa
    29401 aagataaata tgattacttc tattagaaac taagttaaaa aataagcaaa tagatatgaa
    29461 aattagaata atatattatt tatatcttaa ttataacact agataataaa aaatgctata
    29521 taaaattcag aattttcgaa agtttttaag cttattttta aatatactaa taatactatt
    29581 gacattagat agaaaaagta ttatattgac tatataaatt attttagtca aactggaggg
    29641 aaaagatgcc taaatcatat tctgataaag aaagagagta tataataaaa agacttaaag
    29701 aagaagcaag attgtgtatg gagcaatatg gtattagaaa aactactgtt gatgagcttg
    29761 taaaacgggt aaaaatacca aaaggaactt tttatctatt ttttcaatca aaagaattac
    29821 tcttttttga ggtattaaga gatatacatg actctataca aaaagaaatc ttatatgaga
    29881 taaatagagt agatgaaagt attacatgtg aacaattgac agatatattt atgaaattct
    29941 ataggatggt tgatagtact tcaattttaa atctcatgat aaatggagaa tttgagatat
    30001 tggtgagaaa gttaccagat tctataattg aagaatactt tagacatgat gactttgaaa
    30061 ttggagagat tatatcttgc ataccaaatg caaaaaataa agacatagaa agctttagtg
    30121 gagcatttag agcagttttt cttaccatgc tatataagcg cgaggttgga agtaattgtt
    30181 ttgaagatgc tttaagatta atgataaacg gattagttat acaacttatg gaatagaatt
    30241 taaattttgt ttgctaataa cttttattaa aaattattaa caaacaaaaa aattatattt
    30301 tattgaccat atagtcaaaa tagtcaaaaa tttgaaaggg tgatattgaa tgattaaagt
    30361 tgatgattta tcatttagtt atacagatag agatttttta caaaatatta actttgaagt
    30421 aggaaaaggg gaaatactag gatttttagg accatcaggt gcaggaaaat ctacattaca
    30481 aaagattcta attggaatga taactaatta tggaggaagt gtcattgtaa atggagtaga
    30541 gagtaaaaga cactcaaata aattttatga aaatatagga gttgattttg aatttcctag
    30601 tttatatgaa aagttgactg caatagaaaa tttaaaatat tttgggtctc tatattctaa
    30661 aaaactacta tctattgatg agttattaaa atcagtagga ctagaaaatg aatcaaataa
    30721 aagggtatct gagtattcaa aaggtatgaa atctcgatta aattttataa aagctttatt
    30781 acataatcca gatattttat ttttagatga accaacaagt ggtcttgacc catcaaatag
    30841 caaggttatg aaagatataa ttttatcaga aaaatcgaaa ggtaagacta ttattttaac
    30901 aactcataac atgttagatg caacagagct ttgtgacaga gtagcgttca ttgtaaatgg
    30961 taaaatatct gctttagata caccacataa tcttattatg tcaaaaggag ctattaaagt
    31021 tagatatact tactttgata atggagaaaa aacttctgaa tgttttctga acaatactgc
    31081 taatgataaa aatttgaata tgcttattga gaaaaataaa cttttatcaa tacatagtag
    31141 tgaaccaaca ttaaatgata tttttattga gataacaggg aggaatttac aatgaggcta
    31201 aaaaatctta ttttaggaga tataaagttt caatttaagt atggttttta ttttttatat
    31261 ctttttttaa gtattatata tatttgtatt atcaatgtat ttccaacttt tatgagagaa
    31321 aaaatagcta taattatgat ttattctgac ccagcagcaa tgggattgtt ttttatggga
    31381 gctattgtac ttcttgagaa aagtcaaagg gttttaaatt ccttagctgt atctccagta
    31441 aaagtatctg agtatatttt atcaaaggta atttcattag gagtaatatc tagtattgta
    31501 gctatgttta ttgctattac attaaattta gataatatta taatatcaac tataggtacc
    31561 tttttttctt ctattatatt ttctttgctt ggattgataa ttgcaagtaa agcatctagt
    31621 ttgaatcagt ttattgtttt aagtattcct attgagatta tatgctttat tccaccaata
    31681 ctgaatgtac ttcttgacac aaaatcatat gcaaatttgt acccttttaa tatatgtatt
    31741 tctcttatta gtggagataa aaattttata atgattaata ttttaatttt aatatcaatt
    31801 ataataataa tttattttat aacttattat tttatttgta gcagttggaa aaaggtaggt
    31861 ggagtaaaac tatgataaag attataaatg cgtttaaaca agagtttgaa caaattaaga
    31921 gagatgctat gctttttata gtatgtgttt ctccaatatt atgtggagta tttataaaat
    31981 ttggaatacc attaatacag aatatatcac ttaacaagtt ttattatcaa ttaaatttag
    32041 agccgtattt cttgatgttt gatttacttt tagcttttat tacacctttt atgttctttt
    32101 ttgcttctac aatggtcata ttgggagaaa ttgatgacag catttcaaga tatttaatag
    32161 taactccgct tggtaaaact ggttatctta tttcacgatt tggaatacca ggtatcttag
    32221 catttattat tactatgatt ctacttatct ttttttctct aactaaaatt tctctcttgt
    32281 taaacttatc aatttcttta ttagttttat tacaaggagt tattatatca atattagtga
    32341 tttctttatc atcaaataaa ctagaaggaa tggtaattac gaaattctca ggtgttttta
    32401 tgatgggtat tttagcacca ttttttattt taaataaagc acaatatatt ctgttcttct
    32461 taccaacttt ttggatatcg aaggcattta aggaagataa ttatgtctat atgtttattt
    32521 caattgttat atcattaata tggattttat tattatttaa aaagtttagt aaaaaaatag
    32581 ttaaataaga aaatttaata tataaatgta aggttgactt gacagtaatg ttgaaaaatg
    32641 ttacatttaa gatgtaaagt taaccttaca tgaatggagc aaatatgaaa aataaaataa
    32701 agatattaag agaaaaatta ggattgacac aagaacaact agggagatta gttggaacat
    32761 ctagacaggc tataaatgct atagaaactg gtaaaaatga accttcaata tggttggcat
    32821 atgatatttc aagaattttt aatgaaccaa ttgaaagtgt atttttattt gaagaaagtg
    32881 aaagaaaatc aagagcacag ataagtaggg gagaatatta tggctataag aaagataaga
    32941 acatttgatg atgaaatttt aagaaaaaag agtaagtatg tagaaaacgt agataataag
    33001 ataagagaaa tattaaatga catggcagag accatgtaca atactccaaa tggaggagga
    33061 ttagctgcat gccaagtagg agtattaaag cgattagttg ttatagattt aggagaagga
    33121 cttattaagc ttgttaatcc tgaaattatt gaacaagaag gggaacaaat tgttgttgaa
    33181 ggatgtttaa gttttcctga agtatggggt aaattaaaaa gaccaaaaaa agttacagtg
    33241 caagctctaa acgaatacgg tgagaaaata gaaattaaag gttcaggttt tatggcaaaa
    33301 tgtctttgtc atgagataga ccatttaaat ggtatagttt ttacagataa aattattgaa
    33361 catgtaaaat tgtaagatag attggttatt gaatttataa aatattttat agtaaggagt
    33421 taaattatga gattatggca taaggattta attgatgtat tacctaaaaa tcaattagta
    33481 agtcaatgga gagagctact tgctataaaa ggttctatag ataaaaaagg tactccaaac
    33541 catctattag tgaataaagt attgaattat agtatagatg aatttaaatt ttatacaaaa
    33601 attgtacatg atgaaatgtt aaaaagaaat tataaaccta atgaacttaa atatacaagt
    33661 atattaaaat ggaaaaatag aaattttgca aatgatatat ctaatgaaca tagtttaaat
    33721 ttagaaaatt tatatgatga ttggcataat aaaatgtatt taaagcaatg cttatataat
    33781 ttagaagaaa aagcaacatg tggaggaata ccaataaatg aatggaatat attactttgt
    33841 aaatatagta aagattatga attgtggtct ggaaatatca tgttttaatt actatagatt
    33901 aacattatag tattattgta tataaagagg tgattatttg tataataaaa taaaatatat
    33961 tccaataaat tgtgaaatag cttgtaataa attaaaaagg agtatgccat ataaatggga
    34021 tttaaatatt tatcgtggat gtgagcatgg atgtaaatat tgttatgcta tttactctca
    34081 taagtacatc aactccaata attattttga agagatttat gtaaaaacaa atatagtaga
    34141 aaaacttgag agacaactta aaagcagtaa atggaagaaa gaagtaatca atataggagg
    34201 agttacagat agttatcaac caatagaagc tgactataaa attatgccag aaatattaaa
    34261 cctgctaata aaatacaaga caccagctat tatttctaca aagtcagatt taattttaag
    34321 agattacgat ttaattgata agctatctag gattacatat atcaatgtag catctacaat
    34381 taccacagta aatgaagata cacaaaggct tattgagcca aatggtgtgg attcaatgag
    34441 acgatttaaa atgttaaaag aatttagaaa aactaacgca tcagttggtc tacatattat
    34501 gccaattata ccatatatta cagatgattt tgataatata aattcgctat ttagacatgc
    34561 aaaagaatgt aatgtacatt atgttttacc tgggacttta tacttaaggg gtataactag
    34621 aggtgttttt tttgactttg ttaaaaaaga gtttcctgaa ttatttgata aattatcaat
    34681 actatatagt gcaggttcac ttaataggga gtataaaaat caattgtata aaatggttaa
    34741 tgaacttaga tataagtatt ctctatcaag cagttactct aaaataatga aggaaaagtt
    34801 aaaaaactca ggagatgtac agatatcttt ttttgattag ttttatataa aaaaattttt
    34861 tttactatga tgattaaaat ttattaaaat taaaatttat tgacaaatat aaaatttaaa
    34921 tatataatta attcataaaa taaaaatatg aaaggatgat gttgttcggt gatatttgat
    34981 atcataaaat cgttgatata agtattgctg gaaaagagtg aataaaatca aatttaataa
    35041 gcaaacaaag taaagctata gttttattgt tgtgcttaaa aatatttggt tctattttac
    35101 tcttatttaa actcatcttt ttgaagttaa accacagagt aaactctgtg gtttttttat
    35161 tttaaaaata aattttaagg agtggtatgt tttgttaaac aaattatgta tgtatttaga
    35221 aagaccagag ctttataaac aaagtgaaat taatttttgg gatgatgagt atatttcaaa
    35281 gcaattatta aaagcacact tagacactaa ttttgaagga gcaagtagaa attttaactt
    35341 tatcgaggat tctgtaaatt ggatagttac agttgcaaat ccagctaatt atcctaaatt
    35401 acttgattta ggttgtggtc caggtttata tgcagagaaa tttgcacaaa aaggttataa
    35461 ggtaactgga attgatttct caaaacgttc tattaactat gcacaaaata gaaataagga
    35521 gactaattta aacataaatt acttgttcca aagttattta aatatgaact ataatgagga
    35581 atttgatttg gctactttaa tttattgtga ttatggagct ttgtcaactg aaaatagaag
    35641 gttattaatg gaaaaaattt atgatagttt aaaacctgga ggaaaattaa tattagatgt
    35701 atttacaata aataaataca ataattttga ggaaattaaa tattgggaaa taaatgaaga
    35761 tggaggattt tggagtaatg aaaaatatat gtgtctacaa gataattgta aatacaatga
    35821 ttataataca ttagaacaaa ctcttgtaat aaccgaaaaa gatgaaaatg tattttatgt
    35881 ttggaatcac tatttttcaa aagaaagttt cttattagaa gttgaaaata ttggatttaa
    35941 gtctgttgag ttttttagta atgttaaggg tgaagcatat tctgacgata gtatgactat
    36001 gggattagtt ttacaaaaat aataattttt ttaaaatgaa taaataaaaa cttgaaacct
    36061 ttaacaataa aataacataa taaaagctta catattgaaa aatggaaact tttatgttat
    36121 ttttagtaca ttacaaattt gcttatataa aaatcaatac ttgaattatt atttttatgt
    36181 gaaatttatc tatagtatat ttttataaac aagtaatgtt attaaaatta agtatgtagt
    36241 taaaagtgta tagcaaaaag gctgttatat taatgttaga ggttcaggga aaatatataa
    36301 agcaaagtat ttacagataa tgtagattgc acagctataa gttagataat agaattatgt
    36361 aatcaagaat ttacaacaaa gtataagata aggataatgc taaattgcca tacaggtgct
    36421 agatgtgtaa atggatttaa ttaatactat tgataaagtg caacaagcac ataaaccaat
    36481 tgatgagatt attaaaacta taagagatat agttgacata attaaaatat tggaacttgt
    36541 ttataatttt aaatcaaatc aataatgatt aagattaaaa taatattaag gcatcaatgt
    36601 tataagagta caatataagg agtactatat agtactcctt acttatacat attaggcaat
    36661 aggaaatttt ttcatagtta aattttcaag tattttttag gaaactttat aattgagaat
    36721 taagggtata gtatgtgatg aacttactga atttataatt aggttatata atggaataat
    36781 catcaatagt tttactttag ggaaaatata tgcttaagga agtatagctt actaatatta
    36841 ttaaaatgta tatttaaaat gataaaaaaa gaattagaca agtatttagt aaattgacta
    36901 tgcaaaattc tatcaagcag gaaccctatg actttagtca tgggaggttc agtaggtaac
    36961 ttgttgaatt aagtttatat tatttaaata aactacttaa tttagataat ataaaaagtc
    37021 agaattttaa gaatagagct atataatctt agctattagg agaattacta tgataggaat
    37081 atattttagt ggaacaggaa attcaagata ctgtgtagaa aaatttttac aagaatatga
    37141 tataacagca aattcttatt ctattgaaga taatgaactt ttacagcaca tcaataatca
    37201 tgagaatatt atttttagtt atccggtgca atatagtaat gtgccaaaaa tattgaaaga
    37261 ttttataata aatcattcaa ctttgtggaa tggtaaacgt gtttttatta ttgcaactat
    37321 ggctctattt agtggagatg gctctggtgt gttatctaga atattaaaaa aatacggtgc
    37381 tataactgtt ggtggattac atgtgaagat gccagatagt ataggagatg aaaaggtatt
    37441 aaaacattct ttagagtata atagaaagct tgtaataaaa gcagaaaaga aagtaactaa
    37501 agctgctaaa aaactgaaac atgggtcacc accaaaagaa gggttaggtt ttttgagtca
    37561 tattgtaggg ttatttggac aacgattgta ttttatcaac aaaacaaata tgtatacaga
    37621 taaactaaaa attaatactg aggaatgtat tgtatgtggt aaatgtgtta atttatgtcc
    37681 aatgaagaat ctagtaatta aaaattgtat gattgttgca aatgggcaat gtacaatgtg
    37741 ttatcgttgt gtaaataatt gtgctaaaaa agcaattaca ttgttaggta aaaaagttgt
    37801 tgaacagagt aatattaaaa aatatatgta agaaatttaa agttttattg aatgtaaatt
    37861 gatgtatatt ttatgttaga aagagaggtt aaataatgga atactacata gttgattcat
    37921 ttgcaactaa actatttaaa ggaaatcctg ctggagtttg tgttcttgac agaagaatac
    37981 ctttagagtt aatgcagaaa atagcagaag aaaacaattt accagaaaca gcatttgtag
    38041 ttaaaggtaa aggaaattat gaattacgat ggtttactcc taaagcagaa attgatttat
    38101 gtggtcatgc aactttagca gcagcttatg taatatcaaa ttttattgat gttaatgtaa
    38161 aaaggataga tttctttact caaagtggaa agcttgaagt tacacgaaat ggaaatctat
    38221 atgaaatgat atttccagaa ataatgccta ttgaaataga gttatcacca caacaagcta
    38281 atttgatagg ctgtgtacca agtgctgttt attcttcaag agatttaatc ttattgctaa
    38341 acagtgaaca agaagttata aattataaac ctaattacgc acaattgcgt aaattgacag
    38401 actggttagg tataataatc acagcacaag gaagtaatac agattttgta tcaagatatt
    38461 tttgtccaga attagattca gaagaccctg ttactggttc atcacattgt aatcttattc
    38521 catactggtc tgaaaagttg ggaaaacaca aaatggtagc tgctcaactt tctaatcgtg
    38581 gtggtataat tcagtgtgaa gtgttgaagg ataatactgt gaaaatttct ggtgaagcag
    38641 tcttgtttat gcagggaaca ataaagattg atatttaaat aagtataata actaatttat
    38701 tatgaaaaat aattaatttt cttagtgtta acaataataa agtagagtta aaaaacttga
    38761 tttcacttaa atcaatatga tagatgttga tactaagatt gacaagcatg attaaaaaag
    38821 ataatattta atctataaag ataaaaacac agtctggttg gtagtccaga cgcagcaata
    38881 gctgtcagta acctgcctcc ttggttgtcc gttctttaga aagtaattta aggaggaact
    38941 agcaatggac aaaattagtg gaaaattaac agtcttattt gaagaaccat tttgggtagg
    39001 tatatttgaa agacaagatg gtaaaaaata tgaagcatgt agggtagttt ttggagcaga
    39061 acctaaagaa gtagaagtgt atgaatttat acttgaaaga tttttctcat tagattttgg
    39121 tagcattaaa ttagaaaaaa atgtgaccaa agacaacatt ggatacaaaa gaatgcagag
    39181 aaaagtaaaa aaggaacaag aaaaagaaac tatagggact aaggctcaaa atgctcttaa
    39241 gcttcaatat gaagaaagaa aacaggatag aaaaaaccta gctaaaaata gaaaagaaga
    39301 agaaaaagaa agactattta atttgaaaca agaaaagaga aaagctaaac ataagggtca
    39361 ttaattttaa ttaaatatct ttttaataat tgctagaaaa aggtgtataa aatttttaat
    39421 tttatacacc ttaatttatt gaaaagaata aggttttata tttcaattac tttaaaatat
    39481 aaaaatatac taataaaaat tgtaaaaata gtataaatgg tataccaaat gtaaatttaa
    39541 tgtgtttagt tttatgtcta aaagaataca ttccaattat agaacctata ctacctccaa
    39601 ttactgctat agacataaga gtagcttctt ttattctcca ttcgtttcta attgctcttt
    39661 tcttatctat gtacattgaa aagaaagcaa tagaattaat cactataaaa tatattagaa
    39721 taaaattttt cacagtcttg cctccataaa aatatattat acattataaa acaagatatt
    39781 tgttttggaa agttaaattt gtaattagta catataaaat atttgataag aacaaatata
    39841 atattaattg gaaaatttaa aaaaattaaa caattagcaa atagggggta tatttataag
    39901 acacaaagtg ataaaatcta tttagaaaat aatgtaaaat aacaggagga taaagcaaaa
    39961 tgaaatttat agtagaaaaa gaagtttttg ataaattaga aaatgtatgc tttggtgtag
    40021 tagttgcaaa aggaatagat aatactaaag aaatagaaag aataagcaac cttttagata
    40081 taagtataga tagagtagaa gattacttca aagataaaaa agtaaaggaa tcagaagaaa
    40141 ttataccata tagagaggca tttagaagtc taggcatgaa cccaaataaa tttatgagtt
    40201 cgatagaagc aatgacaaca agggttgcta agaataagaa acttcctcat ataaatccta
    40261 ttgtagattt aggaaactct atttctttaa aatatttact tccaatgggt gctcatgata
    40321 tggattttag aaatgatgat gtatatgtta gattttctaa aaaaggggat aaatttgtac
    40381 catttggaga aactgatgtt gaattaatgg aagaaggaga attaatttat tcagttggag
    40441 acatggtaaa aactagaaga tggatatgga gacaaggaga agaaggaaaa attactaata
    40501 gctcaaaaaa tatatttttt cctatagatg gttttactga tgctaattta gataaggtaa
    40561 tgagtgcaag agaagaatta gcaaaattgt taaaggaaat atttaattgt gaaattaaag
    40621 taggttttgt agataaagat aatcctgaaa tggaaatata ataagttgtt gaatacttgt
    40681 taagatatta tatttactta atgatgttaa aaaggtatta aaaaagaaag gtcgtagtaa
    40741 atttgaaaaa aactataata aagaatgtaa atccaatgat tgaaaataag tttataggac
    40801 tttttgaaat agagtataaa aacaaattag atgaagataa ggtttggatg gtagcatcaa
    40861 gaaaaagtag tgagcaatta aaaaatattt atttgaagaa tgaagaagat agtgtagatg
    40921 cagttgtaat agttgggctt cataaaagta gtaaaaaatt aattttaata agacaattta
    40981 gagtacctat taatggatat atatacgagt taccagcagg tcttgttgat gaaggagagt
    41041 ctatagatat ttccgttgaa agagaactta gagaagaaac aggacttact cttttagaaa
    41101 ttaaaaaaaa taaaagtatt gataaagttt atttatctcc tggaatgagt gatgaatctg
    41161 ttgcctttgt ttattgtata tgtgatggtg atataacaga tgaattttta gaaccagatg
    41221 aagagattga agcgctttta atttcgcaag aagatgcaaa agagatttta caaagtaatc
    41281 ataagataga cacaaaagca tttttgattt tacaaatgtt tgtgagttta ggagctaaat
    41341 tatttgaata gatatataga aaagaggtta tatagaagag taaaataata aagtttattt
    41401 tacttgtgta aattataatc tcttttttta tacaataaag tataattttg tgtattttta
    41461 aataagtgat ttgactctta aattttcata atatgttata aaccaattta agatactaca
    41521 ataattaaaa ttccaaaatt atttaacata tttgcaatta aaatgagaaa atgtaaaggc
    41581 tgaatgattg aaaaatttga tgtaaaatag tagcttagtt taatactata gtttgtaggg
    41641 ttaaaaatta gaaattgtaa gggagataaa ttctatgaaa aaattagtta ttattttaat
    41701 tagtatcatt agtatggtta gcttgacagc ttgtaaaaaa agcaatgaaa gtaaatataa
    41761 taatttaaac aacaaagaat ccggacaaac aaccattgaa atggacttag ataaaaatta
    41821 tgatacttca gacccatttg ttaatgcacg tttgttttgt gtgtctaatg atatagatgt
    41881 tttagacaca gagatttctt ttaaaatgga tggagatagt ggtattgtgg aaataaagga
    41941 caataaaaca gatgaaactt tatggagtaa tacatggcat ggaagcgttg ataatgatac
    42001 attcacaatt tctctttcta atatacaaaa agagaaagag tatgctatat gctttactgg
    42061 aattaaaata aatcatgcag ttgtaaaggt tacttttgaa agcaatttag ttaaggagaa
    42121 agaaaaaccc tcaaaataaa ttccagcttt tctataactt gatattcagt acataaaagc
    42181 agttgatatt tatgattgac tgctttttct tatcaaaaag gataggttgt gcatttttac
    42241 ttgaaatagt ttatgcacat caaaagttgg tgagcatgat attggaaatg gtaagcatga
    42301 aatcttgata atacaaggaa ataaatttaa gttttcaatt aagtatattt ccataattta
    42361 gttaacaata agctaattat tatttatatt ttgatatata aataataatt gtagcaaatt
    42421 ttaaaaaatc atatattttt tgaactaaat aaaaatttat ttttattatt ttaaattaga
    42481 ggagattctt gaagatatat tatttttaaa aataagtata gtttaaaaat tcaaaaaaaa
    42541 gatggcaaaa tatgtcccaa gggacattga gtaaaataaa tgatttcagc ttatttacac
    42601 taaaaagtac atactaaatg aggggtaaaa taaagaaaaa tgatatacta attgtctttt
    42661 gataataaaa aaacatggaa tttgattatt taatcaagaa aaagtattga acaaatgatt
    42721 tatttagtgt acaataatca tgtaaaaaca tagtaatgga gggagacatt tcataatgaa
    42781 aattaaggta ggaatgaacg gatttggaag aataggaaga gctgtattaa gaatagctca
    42841 agaagaatta ggagataata tagaaattgt agccataaat gcaagagcaa caacagaatc
    42901 tttggcacat ttatttacat atgattcatg ctatggaact tttagaggtg aagtagaggc
    42961 aaaggatgaa gacactctag tagtaaactc taaagagata aaaatattaa gatataatga
    43021 cccagaagaa ttaccttgga aagaattggg ggttgatata gtaatagaat caacaggatt
    43081 atttacacaa agagaaaagg cagaaaaaca tattaaagca ggagcaaaaa aagtaattat
    43141 aacagctcca ggaaaaaatg aagatataac tatagttatc ggagttaatg agaaagaata
    43201 tgataatgaa aagcacaata taatttcaaa tgcatcttgt actacaaatt gtctagctcc
    43261 ttttgctaaa gtattggacg aaaaatttgg tatagtaaaa gggttaatga ctacagtaca
    43321 ttcatatact aacgatcaaa gaatattaga taaaagccat aaagatttga gaagagcaag
    43381 agcagcggct gaatctataa tacctaccac tacaggagca gcaaaagctg tgtcaagagt
    43441 actaccacaa ttagaaggaa aattaaatgg tttttcactt agagtaccaa caccaacagt
    43501 ttcacttgtt gatttagtgt gcgaacttaa agaaaacgtt acatctgagc aagttaactc
    43561 tgtgttaaaa gatgctgctg aaggagaatt aaaaggtgtt ttaggatatt gtgacaagcc
    43621 acttgtttct atagattata aaggagattc aagatcatct attatagacg ctctatccac
    43681 aatggttata gaagacaata tggttaaggt agtttcttgg tatgataatg aatggggata
    43741 ttcttcaaga actgttgact tagtaaaata tgtagctgaa aaattaaaat aatatatatt
    43801 tcttaaagca aattttaaaa aaatttttta aaaaaattat ataaaactaa aaaaaaagat
    43861 tatgaaaaat attgaaggaa aaattttttc ataatctttt ttctttcatg caaaaagata
    43921 caagttacaa cttatatttg catattaggt cgttagagaa gtatatatat atttagtaag
    43981 gaatcatact ttttataaaa tgaaagataa gatgtcgaaa acttgcataa atctgaaaaa
    44041 tttttattat taaaatactg atttccattt taaaaatgat aaaaaaatga caaataaagt
    44101 tgcaaatagt aatacttata agtataatta aaaaagagaa aaggttttgt taaactttat
    44161 aacaaaaaaa gaagggatga ttcaaaatgg agaagttaac agacaggaga caggttaagg
    44221 cagtaagcat ggaaaccttc attttcctaa tattactagt agttggtttt gggtatgttg
    44281 gtagtattat gggagcagga atgatgttca aagtaataat gagtacagca catgctttac
    44341 tattggagac agttttctta attatggcta tggcagttct tgcaggcgca ttaagcgcac
    44401 tactttcaga gtttggagta atagcgttaa ttaataaaat tttcgctgta tttatgaagc
    44461 ctttatatgg actacctggt gctagtatag caggagctat aacaacttat ttatcagata
    44521 atccagctat tatacctttt gctaaagata aaacattcac acagtatttt aaacaatacc
    44581 aagttccagc attatgtaac ttaggaacag cctttggtat gggacttatc ttaacaacat
    44641 ttatgatttc tcaaggtaca gaatatgtac ttccagcatt aattggtaat ttaggtgcaa
    44701 ttataggtag tgtcataagt gttagaataa tgttgacatt tactaagaag ttttataaat
    44761 acaatccgga agaagataaa gcaacaggaa cattagagaa aaaggatgaa tttagagaaa
    44821 tcagagaagg aaatgtattt caaagagctt tagatgcaat tcttgaaggt ggtaaaatgg
    44881 gggtagatat gggaatggct ataattcctg gagtcctagt agtatgtaca ttggtgatgt
    44941 tattaacttt tggaccatct acagatcctg ttacaggtca agaagtttat acaggagctg
    45001 catatgaagg aataaaatta cttccagtta ttggagataa acttggattt atattagaac
    45061 cattatttgg atttacatca ccagaggcaa tagcattccc tataacttca ttgggagctg
    45121 ttggcgcagc aatgtctcta gttccagagt ttataaagtc aggagctata actcctaatg
    45181 atatagcagt atttacagct atgggtatgt gttggagtgg atatttaagt acacatattg
    45241 gtatgatgga tgcattaaat gctagacagt tggcaggtaa agctattctt tctcatacaa
    45301 taggtggttt atgtgcagga gcagctgctc actttatatt tacactcgta ggataaatgt
    45361 aatcagctaa gataaaaaat aatatacaaa aaatggttgt tgatatgtaa taagaattta
    45421 catatcaaca accatttttt tctgactaaa gataatttat aatacataaa cattaagtgg
    45481 atattagagt taagttatat ttatgtaaaa agtaacaaaa atctgtagaa atttatgaca
    45541 aaatttagta cactaactat atgttcttat ttaaaattta aggttagaat taggaattac
    45601 ctagtagagt aagctttgat taataaaaga atcataaaat aaaaatatta gtcataaaga
    45661 ttataaataa cttacttaaa ataaagccat agaacttaca aaaattaaaa aagcatataa
    45721 atatggaggg gtacaatgga tgaattattt catataggaa ttgatgtagg ttctacaacg
    45781 gtgaaggttg tggtacttaa taatagtaat aatatagttc ataaagaata tagaagacat
    45841 tattctgatg taaaaaaatc agttaaagaa gtactaaatg gtatatatga aaaattggga
    45901 gatataaata ctaccattat aataactggt tcaggtggaa ttggaatatc aaaaaaatta
    45961 ggtgtaaaat ttgttcagga agttatatct agtacaaaat caatagagta ttttcatcct
    46021 gaaactgatg ttgtcataga acttgggggt gaagatgcaa agataacata tctaagtgga
    46081 ggaatagacc aaagaatgaa tggaatatgt gcaggtggca ctggagcatt catagaccag
    46141 atggcatcac ttttaaagac agatgccagt ggattaaatg aacttgctaa agggtataat
    46201 gttatatatc ccatagcttc aagatgtggt gtttttgcta aaacagatat tcaacctctt
    46261 ataaatgatg gagccaatca gactgatata gcaatgagta ttttcaatgc agttgtcgta
    46321 caaactgtga gtgtcctttc ttgtggaaga aaaatagaag gaaatgttgc gtttttgggt
    46381 ggtccattgt actttttatc tgaacttaga gaagcattta aaagagtatt agatttaaaa
    46441 gatgaaaaca taatcttccc agaaaatgca caactttata ttgctattgg agcaggatta
    46501 ttatcagtag atgaagataa tatacaacta aaatctctaa tagaaaaatt ggatagtata
    46561 aagaatattg aagatggaga agtaaattta ttagaacctt tatttaaaga taaaaatgag
    46621 tatgaagaat tttcaagaag acatgaaaaa gaaaaaataa attatgtgga cataaattca
    46681 ataaaaagca attgttattt aggaattgat gcaggctcaa ctacaactaa agcagcactt
    46741 attgatgagg atggaagact tgtatattct tattataata gcaatgaagg aaatccatta
    46801 aaaacaacca ttaaagttat aaatgaagta tatgatatat taccaaaaaa tattaaaata
    46861 ttgagttcaa ctgtaactgg atatggagaa ggtcttatta aaaaagctct taaaatcgat
    46921 aatggagaga tagagactat agcacattac aaagctgcta aatttttcaa caaagatgta
    46981 gattttatac ttgatattgg tggtcaagat atgaagtgcc taaaaataaa agatggagta
    47041 attgataata taatattaaa tgaggcttgt tcatcaggtt gtggctcatt tttagagaca
    47101 tttgcaagtt ctttatctat gacaatagaa gaatttgcgc atgaaggtat ttattctcaa
    47161 aatcctgtag atttaggttc aagatgtact gtatttatga attctagagt aaaacaagct
    47221 caaaaagaag gtgcaagtgt tggagatata tcagcagggc tatcttattc agtaataaaa
    47281 aatgctttat ttaaagtaat aaagattaga gatttaaatg agattggtaa taatattgtt
    47341 gtacaaggtg gaacctttta taatgatttg gtgcttagaa gctttgaaaa actaattgga
    47401 aaaaatgtaa ttagacctaa tatttcagga attatgggag cttttggttc agcacttata
    47461 gctaaagaaa aatatgaaag tggatacaaa acatccttgt tatctaagga agagttgaat
    47521 aatatcaagc tagaagcaag tgtaactaga tgtaaaggtt gttcaaatca ttgtcttctt
    47581 acaataaata aattttctga taatgaaatt tttatttcag gtaatagatg tgagaaaggt
    47641 gaagctattt atggtgataa aaaaatagga ttagaaaaga aaaaaccaat aaatttattt
    47701 aagtacaaat acaatagaat ttttagatac aaaccattgg aaaaagaaga agcaaaaaat
    47761 ggggaaatag ggataccaag agtattaaat atgtatgaag attatccatt ttggtttact
    47821 tttttcaatg ctatgggctt tagagttgta ctttcagata ggtcatcaaa acagttatat
    47881 gaaactggta taactagtat tgcatctgaa acagtttgtt atccaggaaa attagttcat
    47941 ggacatatag aaaatttaat tgcaaaaggt ataaaaaata tattttatcc aagtgtaaca
    48001 aatgaaaata aagaggattc aaatgcagat aattattata attgtcctgt tgtaatatca
    48061 tattctgaag taataaaaaa caatgtagag aatataagaa ataagaacat aaattatata
    48121 aatccattta taagtctaaa tgacaaggaa aaattgaaga aaagactcta tgatgaatta
    48181 tcaagacatt tttctgatat aaaaataact aaagaagaag ttaatcatgc agttgataaa
    48241 gctactgatg aacagaattt atttaaaatg gagatacaag cagcaggtga aagagcactt
    48301 aaagaaataa aagaaagaaa tatgaagggg attgtgttat gtggaagacc atatcatata
    48361 gacccagaaa taaatcatgg aatgccagag cttataaatt cattagatat ggcagtgctt
    48421 actgaagact ctatatgtca tttagccaat gtacaaagac cacttagagt tgtagaccaa
    48481 tgggtatatc attcaagatt gtataaagca gctagttttg taagagataa aaactatttg
    48541 gaacttgttc aacttaattc atttggctgt ggattagatg cagtaactac agaccaggtt
    48601 caagaaatac ttaatgaaaa atcgaagata tatactatta taaagattga cgaaggcaac
    48661 aatttaggag cagctaagat aaggatgagg tccttaaaag cagctatgtt tgagagagaa
    48721 agcaaaaata tagatgtaaa aaatataaag gtaaacagga tacagtatgc taaaaataat
    48781 cagataacga acaaacatac tatattagca ccacaaatgt ctccaataca tttccaattc
    48841 cttgaaaaag ctgttaactt aagtggttat aatatagaaa ttctaaaaga tactgatagt
    48901 agtgtaattg aagaagggtt aagatatgta aataatgatg catgttatcc agctataata
    48961 gttgtaggtc agctaataac agcattaaaa tctggcaaat atgatttaaa taacacttct
    49021 gttactataa ctcagactgg tggaggttgt agagctacaa attatattgg attcttaaga
    49081 aaggctatat acgatgctgg atttaaagat attcctgtca ttgcacttag tgtaaatgga
    49141 atagaagata gtggtataat ggataatata tcactaaaat taatcaatag actctttatg
    49201 tctgttgttt atggtgattt gctgatgaaa gtactatata gagtaagacc atatgaaaaa
    49261 gttactggaa gtgcaaatgc tctatatgaa aaatgggttg atatatgcaa atcttctctt
    49321 gttaaagcaa aaatttctgt atttactaga aatataaaag atatagtaaa agaatttgat
    49381 aatttagaga tactagatat caaaaaacca aaagtaggtt tggttggaga aatattggtg
    49441 aaattccatc caattgcaaa taataattta gtagatatat tagagcgaga aggtgctgaa
    49501 gcagtcgtgc cagaccttac aaatttcttc ttaagttgtg cctttaatac tatatacaaa
    49561 cacactcatt tagaaggaag tagaaagagt agaatgatag gagaagcatt tatatacata
    49621 actggaatat atcaaagagt atataaaaaa gcacttgata agagtgagag attttatgct
    49681 ccagccaata taaaaaatgt tgctaaaagt acagaaccag tagtgtcatt aggtaatcaa
    49741 actggagaag gttggctttt aacaggtgag atggttgaat tattaaatga aggtgtagaa
    49801 aacattattt gtatgcaacc ttttggatgt ttacctaatc acataattgg taagggttct
    49861 ataaaagaat taaagaggtt gtataaaaat gcaaatataa tacctattga ttatgaccct
    49921 tctgcaagtg aggtaaatca acttaacagg ataaaactta tgctttctaa ggcttttaaa
    49981 aatatataag atttatattt tgatatgtta aaagttaatg aatttaaaaa tatactctat
    50041 attaagtatc tataaaaaag agttatccta ttttttaggg taactcttta ttagttaaaa
    50101 aattatatgt atactgatat taaagggggg aagtaatatg agtttagtat atgatgttta
    50161 taaatcaaaa ttaggaaatt tgtacatatt aagtgaagat ggttttatag ttagtatata
    50221 cataggagat gaaaaattta ataatttaaa aaatgaatgt attaaaaaag gaattgatat
    50281 aaagagaagt aaggaagatt taaaggaagc aataagccag atagatgatt actttaatgg
    50341 aaaaagaaaa gtctttaatt taaatattcg tattgaaggg actgaatttc aaaaatcagt
    50401 ttatagggaa atgttaaaaa taccttatgg agaaacattg tgttattcag atatagcaag
    50461 aaatataaac aatccaaaat cagtaagagc aataggacaa gcaagtaaaa gtaataaaat
    50521 tccaataata ataccttgtc atagagtagt tggcaaaaaa gatattggtg gatatatggg
    50581 gaatcattct gatttgaaag agatactatt aaatttagaa agacagagtt aacttagaaa
    50641 gaaatgtttt tattgttaat atttgatata ataatagtaa aaagaagtat tttttacaaa
    50701 aacaatgaag aatttatttt aatttataaa aatgaggggg aattttaatg tgtgataaag
    50761 ttatagcatc aaaatatcat gagaagggat ttaattgtgc agaatcagtt ataaaagcat
    50821 ataatgagga atttaataca gatataccag tttgtttagg aagtggactg ggttcagggt
    50881 gtggggttgc tagtttatgt ggtgcagtaa atgcatcaaa tataataatt ggatatgtaa
    50941 aaggcagaaa ccacgaagat gaaagtacta aagctaaagt atatgctaaa gatttaacta
    51001 caacagtaag aaaagagtat ggttcagagt tatgtataga cctaaaaaaa gatttagttg
    51061 cttgtagaga aataatggat ttcgcatatg atagtctaaa ggaaacttta aaaaaagaat
    51121 tataagaaaa taagctatca agtataaatt atttgatagc ttatttttat agtcgatact
    51181 aaataaatca aatatatttt agaattatta tttgtaaata aacagcaaat aattttagga
    51241 tttttattta atatagtttt tatttatatt tatttttgaa tatgttatac tttgtttaaa
    51301 taaatatttg taatgaggga gatgagaaga ttgaagaatc tcaatttact tattaataaa
    51361 ttatattcaa aaaatcataa tgaagcatat aaaacttttt tattcttaga aaatgaaagt
    51421 ttaaaatcaa atattacata ttgttttttt gactcattcc tagaaatgat tgataacgaa
    51481 aactcatata ttcgaacaag gggattgtta ttaatctctg caaatgctca gtgggatatt
    51541 gataataaaa ttgaaataaa tatagatagt atactaagtc atatcgtaga taaaaaacct
    51601 tctgtatcaa gaatgtttat taaatccata cctaatatta caaagtataa agaaaatctt
    51661 attaatcgca taaaaatgga attaagtaat gcagatataa gtatttataa taataatatg
    51721 aaaccattag tagaaaagga tataaacgat acattatcta atattagtta aatattaata
    51781 tagaaattga atattatcta gttacaatta tttataacta agataataaa acaacaatgg
    51841 tgctaattta tatgtataaa ttaattatga aaaatttata taagtaaaat atattaacat
    51901 aaaggtaaaa ttttgtatac taaaagggaa tatttacagt ttaatggcag ttttaaaata
    51961 ataaattaaa gctgtcattt ttatttaaaa atttttagaa aaagtacaat agtgttaatg
    52021 tgtgaattag ataaggtgta tataatagtt tagatgatat gatataaaat atgttgtaaa
    52081 ttaaatgttt tctttgacaa tatatacaca aggatgataa tatctatatg aataaaagat
    52141 agtgtgtaat ttgataatat gtaattataa cattatgata taattacaat aaagtatgta
    52201 ataatctgta gaaatttcaa gctagttatc taagttttcg gataactaaa tctaaacgga
    52261 atacataatg tattaaataa atgatgatac taaaatgata ctatttttat agaaatttat
    52321 tgaggtatat aattaatgaa aataatatat taaattatat aaattaaatt atataaatta
    52381 aattatataa tatattgagt tttacataaa agcaaaggtg ggaataaaaa tgaaagaaat
    52441 tgctgatgct ataacatcag agtatttaag ctatggtatc aatgaagata ttagtatcta
    52501 tgaaggtaga ttttgcatat atttagataa aaaatataga tgtaatggga aaatttatta
    52561 taaaatgaca cctccaatat ctataagttt taaagcagac ataggttgtg ttgaagagat
    52621 agacaatgaa gatgacaatt tagctttaga ttatgataat gctattcttg aagttcatgg
    52681 atataaaatt atttctataa caataaatac tttaagtgaa tttagtgtag aaggttatat
    52741 caatgatgac tgcataaaat ctaagaactc ctatgttgaa tatgtagatt ttaatataat
    52801 aaacttagat aaaatacctg gaaaactcat taaatacaat gataaggtat acgcaggtag
    52861 aattgaattt gatataaatg attatgttgt aactatagac aagcgatatg attatagaaa
    52921 agaattaaaa tcagaattaa agtctaaatc tggagcaata ataactcata taggtaggat
    52981 tagaagaaaa gatggtagaa tttttagaac aaataataca ataaatcttt tagataggat
    53041 atcaacagct ttgagtttta tgtgtggaag atatgtaggg ttttgtttgg ccaaagggta
    53101 tagaagtggt aatgaagttt atagaatatg gaatgaaaat caaatatctc cttttagata
    53161 tgtaccaaca tggtcagata cactttcaaa ttattataat atggaaaaat atataagcct
    53221 tatgtgtaaa aagctagaag atttttatta tggttctgct ataaagagtg ttgttgattg
    53281 gtacatagaa tctcttggaa gtgctaccat ggaaaacaat ataatatctg tacaaattgc
    53341 acttgaaact ttgtcatatg taattctagt ggaacaaaat aagatactta cagatgaagt
    53401 atttgactgt aatttggcat ctaaaaatat aagactctta cttgatacat gtaagatacc
    53461 atatggtaaa catgaattaa atatatttga taatataata aaaaataaat ttgatgatgg
    53521 agtggattta gttatttatt taagaaatag catagttcat ccaagtagaa agactcatag
    53581 agctgtgtta gaggttgaag atatttggaa tataatttca ataggaacga gatatattga
    53641 acttgtttta ctctttattt taggttatag aggagaatat tcaaacagat tagtagaaag
    53701 atgttatggt gaagtggaag ttgtaccttg gaactagatt tttatattta ttttaaaata
    53761 tatattgaca tatattgcct tatgctataa aatcaatatc ataataataa ttcagaataa
    53821 cattaaatgc taagaaaaga aatagtaaaa gtagttaatc ttaaacagag agtttccgat
    53881 tggtgagagg agcaatagat tttactttga acacatcttt gagcaggact ctgaaagagt
    53941 agaaatactt tattaggaga tttccggaat ccttgcaccc gttatagtgc tagagtataa
    54001 taattttatt gtacttaaag aggttagtgt cgtgaggcat taatgaacag aggtggaacc
    54061 acgagagtta actcccgtcc tctagcagaa gctagaggcg ggagtttttt aatataattt
    54121 tttaagcgcg cagagaatta tattgcaata gatacacttt ttaaaaaata atcaaaatat
    54181 tttaaaaatt aaaaggcgag ggagaatatt atgaaaaata tattaaaaaa agtaggaata
    54241 tttacaatta tgttaggttt attaggtgga gttgtaggtt gttcaaaacc agataatgaa
    54301 aaagataagg atgcttcaaa ggaatctaaa aaagaagtag ttgtagggtt tgataatacg
    54361 tttgtaccaa tgggattttt agatgaaaag ggagatacag taggatttga cgtagactta
    54421 gctaaagaaa catttaaaag acttggaatg gaagttaagt ttcagcctat agattggtca
    54481 atgaaagaaa ctgaattaaa tgattcaaaa actgtagatg tattatggaa tggatattct
    54541 ataacagacg aaagaaagaa aatagtatca tatacagaac catatttaca aaataagcag
    54601 ataatagtta ctctaagtga ctcaaaaata aattcaaaag ctgatttaaa agataaagaa
    54661 gttggaacac aacaaggttc aacagcactt gatgcagtgg aaaaggataa agattttatg
    54721 aatagcttaa aaggtggagc accagttctt tatgatactt atgataaagc acttagagat
    54781 ttagagatag gtagaactag tgcagttgtt ggtgatgaag ttttaattag atactatatg
    54841 ggacaaaagg gtgaagacaa atacaaggta ttaaaagacg attttggatt agaagattat
    54901 gttgtagcaa cttctaaaga aaatccagaa ctttgtgaga aaataaatga aacattaaaa
    54961 gaaatgaaaa aagatggaac ttttgacaag atttatgata agtggtttaa atagaagata
    55021 agttagctgt taagaagggg gcactaaagg catgttacaa ggtttagaga tagttatagc
    55081 aatgttttgt ataacattga tagtatcaat tccattgggg attggagttg catttttaag
    55141 attatcaaag aataaattag taagtggtat tacacaatgt tatatattga taatgagagg
    55201 tacaccttta cttttgcaaa tgatagtcat attttacgga ttacctcttt taggaattgt
    55261 atttgacaga tttacagctg gagtagtagc tttcttctta aattatgcag catattttgc
    55321 agaaatattt agaggtggaa tacagtcaat cgatagagga caatatgaag cttcaaaagt
    55381 actaggattt gataagttta ctatgtataa gagagtaatc tttccacaag tttttaaaag
    55441 aatactagca cctatttcaa atgaagtaat cacattagta aaagatacat ctttagtata
    55501 tatattagga ttaaatgata ttttaagaat atctcaaata gcaatgaaca gggaagcaag
    55561 tctgttacca ttatttgagg caggagcgat atatcttata tttgtagcta tacttactaa
    55621 gggatttgaa ttacttgaaa aaaaatattc ttattataga taaagttaca atattatagg
    55681 aggaggtttt ttatatgttg aaaatcaaaa acttaaataa atcatttaaa aaaaatagag
    55741 tacttaaaga tatttctttt gagttagaag aaggtcagat tggagtttta cttggtaagt
    55801 ctggtgcagg aaagaccaca atattaaggt gtataaatgg tcttgaagaa tttgatagtg
    55861 gagagattat aatagataat gaggtaataa aaaataagag agatatggca aaaatacgag
    55921 gaaaaatagg tatggttttt caaaatttca acttatttcc tcatatgaca gtccttgaaa
    55981 atataattga atccccagtt aatgttttta aagttcctag aaaagaggct gaagagaggg
    56041 ctagagaact tttaagatta gttgatttag aagataaatt aaattcttat ccatttgaat
    56101 tgtcaggagg acagcaacag agagttgcta tagctaggtc atgtgcattg atgccaaaag
    56161 tcctttgttt tgatgaacct acttctgcac ttgatattga tactattcaa agagtagtca
    56221 atataatgaa cagacttaaa gacaaaggta tgacaatatt aataattaca catgatgttg
    56281 tcttctcaaa taatgttgca gataaaatta taagtataaa agatggtata gtagaaaatg
    56341 ttcaaataaa agaaaaaatt gtttagagtt ttataaatat aaactagggt agaattttat
    56401 aatataaata aagggcaagt aaaatcaaat atactatgcc cttttgttat ctcaaaattt
    56461 aatcttatat tttatgttta agttacatta taatttataa taaaaataaa aggactattt
    56521 aaatatataa tgtgaataat gtttaataat ttgaaatatg ataatttttt atgttgaaag
    56581 cttataatga ttatgatata aattggttat agtatacaat ttatgggtat aacaataaaa
    56641 aattagaaag gaatttttat aaaatgatta aattatatgg atatacaaaa tgctctactg
    56701 ttaaaaaagc taaaaattgg cttaaggaaa ataatttaga atttgaagat atagatatgg
    56761 ttcaaaaccc tcctagtaaa gaggagttaa aatcaattta taagactagt ggatatgata
    56821 taaagaaatt ttttaataca agtggtatga aatatagaga attgggtctt aaagatattg
    56881 taaaaactga atctgatgat aaacttttag aaatattggt aagtgatggt atgcttatta
    56941 aaagaccatt acttttggat ggtaaaaatg tattattggg ttttaaagaa gatgtatgga
    57001 aaagtacttt gctaaaagaa gattaggaag agataggtgt gttgattaaa attattaatt
    57061 aatacaccta taaatttatg tattaaatct aatctttata aatattaatt agcaaattca
    57121 aatcaaaaaa attcatatca acaaacatat tacttcttat tacaaattat atcatatgtt
    57181 ttatattaaa atattataat attacaacga attgttacaa aattacttat tattaaccat
    57241 gaacatttgt tttgtgctat catatttata taagggaatt gtcataaaaa atatcttgtt
    57301 catacagttt tatatagaaa aaagaaatga atcttttctt tatataagta tattttgtaa
    57361 attgcctcta tatttatagt ttaaataata gtggtattaa aaatctgaca acaaaaataa
    57421 aactttcaaa aaattaaatc taaaaagaat aggagataaa tatgagtatt gaagatttat
    57481 atgattttga atgtgttcct ttgaacaatg agattgatat tgatgtttta tttgaaaaga
    57541 tgatagaaga tggaaaagaa aaagaatata caccaattat agtcattgat gaaaaagtag
    57601 ggctattaag aaaaaatata gatatgatta ctaaagagta tggttctctt gaaaactata
    57661 gagagtattg tttaacaaaa tataatgaaa ttgatgtaaa tcaatttttt gattttagga
    57721 agagtgagat ttcagaatta ttaaaggagc taattgattt agaagatgat ttttatgatt
    57781 ataaacattt tagacccatt atgaatatag atatatttca tgaatataac aaagtttaca
    57841 tagctaaaat tccaacaatt aaaccatatg aagtatttgc atacatacct attggcggat
    57901 ttaatgattg tcctagagat gaagaacata tagctattgc aaaatattgg tatgaaaagc
    57961 atggaatctt tccaatcgca attggatgtg atacagttca atattctgta aaaaatttaa
    58021 ctaaagatgg taaaaaattt gatgacttat gtattgaatt agtattttat tgtgaggata
    58081 ttattataca agggtatgaa accttaaagg ctcttaagga tgtattaaaa cgctctacaa
    58141 tagtgctttt ttggtgggat tgatattcta tcatttagat agtattaaat tgttagtcac
    58201 caagaatcca cttgctttag ttatagggag tgtgtcaaac taggttttta tacacagtgt
    58261 agcatagtaa tatgtttaaa ttacaaaggt taaaaaaata ctttaatatt tttaatatta
    58321 taattaatag atttaaggta attataattt ataaaataaa tactttatat gttataatca
    58381 ttaagaatgt aaaaaaataa tatatagttt tatagttcat atttttccag atatggaggt
    58441 aaattttgtg aaggaaaaag aaaaattaga taaattaaaa aaaatgttac ttgaattagg
    58501 cagtgttgta gttgcttatt ctggtggagt agatagtaat tttttgctta aggtcgcaaa
    58561 agatacatta ggtgaaaatg ttatagctgt gactattcat gcaatgatgc attcaagtag
    58621 ggaaattgaa gaggctaaac aatatactca aaattttggt gttaaacata tcatattaaa
    58681 tatagaaaac tttgatttaa aagaatttaa agaaaatggt gttgatagat gttatcattg
    58741 taaaaaatat atattctcta aaataaaaga ggtagcaaaa gaacataata taaagtacat
    58801 agtagatgga acaaatatag atgatttagg agactataga cctgggctta aggcattgag
    58861 tgaattagga gtaattagtc cattaaaaga tagtagttta aaaaaagaag aaattaggtc
    58921 gctttcaaaa acattaggat taaatacttt taataaacca tcatttgcat gtcttgcgag
    58981 taggatacct tatggagttg aaataacaga tgaaaattta agaatagtag aaaagagtga
    59041 agaatatcta tccaatttag gtttttctca atttagagtg agaatgcatg gagatatagc
    59101 tagaatagaa gttggacagg aagagctagg taaatttttt gaaaataaca attttaataa
    59161 agttgatact aaattaaaaa tatttggctt taaatatgtt acactagata tgtcaggata
    59221 taaaatggga agcatgaatt taaatgtgta gattatttta aaaataaata agttttatag
    59281 ttaatataag gaaacaggag gttttatgaa aaattatacg ttaatatcgc catgtttttt
    59341 tggaatggaa aaaatgctgg ctagagagat tactaattta ggatatgaaa taataaaaac
    59401 agaagatgga agaataacat ataaaactga tgagtttgga atagcaaagt caaacatgtg
    59461 gttgagatgt gctgaaagag tacatcttaa aattgctgaa tttgaggcaa aaagctttga
    59521 tgaattattt gaaaatacaa aaagaataaa ctggtctaga tatatacctt atggagctca
    59581 atttcctata tcaaaagctt cctctataaa atcaaaatta tacagtacac cagatgtaca
    59641 agccatagta aaaaaggcta tagtagaaag cttaaagaaa agttatttgg aggatggttt
    59701 gcttaaagaa gataaggaga aataccctat ttttgtattt atacacaaag ataaagtaac
    59761 catttctata gatacaacag gagatgcttt gcataagaga ggatatagag aaaaggcaaa
    59821 taaagctcca ataagagaga ctttagctgc tgggcttatt tatttaactc cctggaaagc
    59881 aggtagagtt ttagtagacc ctatgtgtgg ttctggtact atattgattg aagctgctat
    59941 gattggtata aatatggcac ctggcttaaa tagagagttt atatcagaaa agtggagaac
    60001 tcttgataag aaaatatggt gggatgtaag aaaagatgct tttaataaga tagataatga
    60061 atctaaattt aagatttatg gatatgatat agatgaagaa tctatagata tagctagaga
    60121 aaatgctgaa atagcaggtg tagatgaata tatagagttt aatgtaggag atgcaactca
    60181 atttaaaagt gaagatgagt ttggatttat aatcactaat cctccttacg gagaaagatt
    60241 agaagataaa gacagtgtta aacagttgta taaggagctt ggttatgcat ttagaaaatt
    60301 aaaaaattgg tcgtattatt tgataacttc ttatgaagac tttgaatatg agtttgggca
    60361 aaaagcagat aaaaaaagaa aattgtataa tggtatgtta aaaactaact ttttccaata
    60421 tccgggtcct aagcctccta gaaataataa ataagtttta catgatttat ttgtaaaata
    60481 taaaatttta ttaaaataag taaaacatta tgatgccctg aaacgtctaa ttattgtgag
    60541 gagatttttg tgaacaaatt taaagattta taggattagg aggagttaaa tgaaagtgtt
    60601 aaagcttatt actgtagtag ccctgatgat gttatttgtt actggatgta atataaaaac
    60661 tgaatctcca gaacaattag cgaagatacc tgactatgat gatacaaaaa aagtattgta
    60721 tgatggtatt gaccagttac taaaaccaga ttcatctatg atattgcctt ctaatacaaa
    60781 agaagtagga aaaataaata aggtagattt aaacagcgat ggaattgatg aattagtagt
    60841 atttgaacaa aaagaagatt taagtaataa tgtgagtcag gtagggtttg taaccttgag
    60901 ttacaatgga gaaaaatacg tacttggaga ccatttttta gaaaatggcg aatcaataga
    60961 atatgctaat ttttatgatt tggactcaga tggatataag gaagttatct tattggttaa
    61021 atccaaagac aaaacgaata tgcatatata taaagtagta gataatgaaa taacaaaaat
    61081 atatgacttg gatgcatcat ggcttcaaaa taaagaagat tttaatgaca tgaaagtaaa
    61141 aattggatat atagatggag atgacaagtt agacatattg atgcttcatt tgaataataa
    61201 gactaatgaa atgtttgcaa gtgttgcaaa ttttgatggg aaaatgaaaa tcaaagattc
    61261 tgttaagttt gaaaatgtaa aaaacttaag tgaattatat ataacattag gtaatgttgc
    61321 ttcatctgtt ggaaattctt ctgcagctat aaaaggtatt gtacttgata ttcctatatt
    61381 gaaagataat aactatatta cgcagatact ttatatgaaa gatgggaaaa ttaacaaagc
    61441 ttttagtgat tatgataaaa ctattactaa atcttattat atacctgtag atgatattga
    61501 caaagataag attatagaaa tacctatagt tgcaggcagt acaggtaata ataaaaatac
    61561 ttatagttct aaatcatctg caactataag ttggtataga tggaatggaa aagaaggtgc
    61621 tgactcaagt ttaatattta caagtcagat atattataat tataaatata attttaaatt
    61681 atttattcca aataatttat ttgataaaat acttgttgaa caggaatttg ttggagaaaa
    61741 agcagtattt aaattttact attttgacta ttcagaccgt aagaatttat ttaatatagt
    61801 agtagagagt aaaaataaac ttgaagatag aaaaaataca ggtactcaaa attctattgt
    61861 acttcaagag agcgatgaat atactttctt actagttgta aacaatgcaa atgaaatgga
    61921 taagctagat atgactatag acgcattaaa agaatatttc tcattaatat atggttaata
    61981 ttatactcaa ttggaggttt tattttatga aggaaaagat acttatacta gaagatgaaa
    62041 ttggtattag aagttttgtt agtataaact taaaaaggga aggctatgaa atagttgagg
    62101 caggtactgg aagagaagct atagaaaaaa tgacaacaga aaaggatatt acaatagctc
    62161 ttttagatgt aatgcttcca gatataagtg gtatagaagt atgtaaattt ataagggaga
    62221 attttgacca agtaggtata ataatgctta ctgctaaagc tcaagaagat gataaaatag
    62281 aaggatttat ctcaggagca gatgattaca tcataaaacc atttagtata aaagagcttt
    62341 tagtcagagt ttctgctctt cttagaagag tagcaaagga tgattcaagt gttaagtcga
    62401 gtgagatagt ttctccacca tttatacttg atatagacaa aagaaaatta tttaaaaatg
    62461 gaaaggaaat tgagcttaca ccaactgaat tttcaatagt gaaatatcta atatcaaatg
    62521 ctaagcagtc gttaagtaga gaccagatat tagacgaagt atggggaact aactatttat
    62581 atgattttaa aatagtagat gtaaatataa gaaggataag aaataaaata gaagatgacc
    62641 catcaaaacc aaaatatata caaactattt ggggttatgg atactgtttt agaaaggaag
    62701 aataatagtg ttacattttg aaggtctgag aaaaaaagta ataaaaaact attttataat
    62761 aattattata atggttactc tgtttgaagg attgttcatg ttttacatac aaaactacta
    62821 ttatgattct gtcaaacagc tacttgaatc tgaaataaaa tatgctgatg aatataatgc
    62881 tattacaatg gaaactacaa gttttgagaa aaaagtaaaa aatatatttg ataaacaacc
    62941 cttaactaaa aattcagaat ttggaatttc aataatagat aaagataaaa atattatatt
    63001 agaccaatat ggttttaaaa gtaaagaaaa agcaaactat gaagatgtta acaatgcatt
    63061 aaaagatata aaaactaaaa atttaacacc ttatacttat agaataccag atacagggga
    63121 gcatgttatg agtatctcct taccacttaa ggtaaataat ataatagaag gtgttgttag
    63181 atatacagta tcattagatg ctattgataa tgcaatatta aagcaagcta catggcttat
    63241 attagcagga atatttatac ttattatagc tatactaata agtcttaaat ttgctgagac
    63301 tcttataaaa ccattacgag agctaaagaa atttgcaaat gaattggctg taggaaatta
    63361 taatataaaa ttagaaaaga tgaagattgt agatgatgaa attggtgatt tagcacagac
    63421 atttgaacac atggcacatg agattgacaa aagtgaaaaa ttaaaagagg aatttatatc
    63481 atctgtatct catgaactaa ggactcctct tacatctata aaggggtgga gtgaaacctt
    63541 aggttatgaa agtataacaa gagaagaact agacttaggt ttaggcatta tacaagatga
    63601 aacagaaaga cttataaaac tagttgaaga attattagac ttttcaaggc tttcttcaga
    63661 caggataaaa cttcatgttg atatagttga tgttgaaggt ttaattgtag gtgttgtaaa
    63721 tcaacttaaa gttaaagcag ctgaaaaaga tatatcactt ttatttgaat ttgaaaatga
    63781 atttatagag aacattcaag gagataaaaa tagattaaga caggttctca taaatttaat
    63841 acaaaattca tttaaattta cgagtcaagg tggttacata aaagttgtag cttctcaaga
    63901 tgaagagata acaaccatat cagtagagga taatggttca ggtatagaaa agcaaaattt
    63961 aaataaagtg ttagataaat ttttccaaga agattataat aaggctggta gtggattagg
    64021 actagcaatt agtaatgaaa ttgtaaaact tcatggtgga agaatgaaaa tagaaagtga
    64081 aaagaatgtt ggaacaaaaa taacttttaa tataaaaaat aaatttgcta aacaagcata
    64141 aattcttaga aagaggatta agatgagaaa cataaaaatg atagtagcat acgatggttc
    64201 aagatataaa ggatatcaaa aattaggtga caataatatg actattcaag aaaaacttga
    64261 aaatgtttta agtaaaatga ctaatgaaac agtggagata ataggttctg gaagaactga
    64321 tatgggagct catgcaagag gacaagtggt aaattttaga actaattgta tggattcttt
    64381 ggataaaatt caaaaatatt tatatgaata tttaccagaa gatatagttg taaaaactgt
    64441 tgaagaagtt gatgaaagat ttcattcaag atacaatgta aaatcaaaga cttatatgta
    64501 taaaattgac aataataagt atcataatcc ttttataaga aaatatgcta ctcatgtaag
    64561 taaaaaatta gatttagata gaatgagaaa agcaagtgag tatttagtag gagaacatga
    64621 ttttactagt tttgcttctt ctaaatctaa gaaaaaatca aatgtaagag aaatttattc
    64681 tataaatata aaagaagatg ataatgttat agaaatatat gtagaaggaa atggattttt
    64741 gtataacatg gtaaggataa tagtaggtgc tttgatagat gttggtctaa aaagaagagc
    64801 tccacaagat attaagtata tgcttgaatc aaaagataga tgtcaatcat cagatactgc
    64861 accagctaaa ggactatgtc tttggaaagt aacatattaa tcaattatat aaaactctct
    64921 ttaaaataaa aataaaataa attatatagt tgacataaat ggaaaaataa actattatat
    64981 attttataag agagatataa aactttatat ttaaatcctg tgagaaagag agtaacttct
    65041 atgtgtttta tagagagctg aggatggtgg aagcttggca aataagtatt agtgaaaaga
    65101 actttggagg atactaattg aatttagtat gttagtaggt aatctcgcct taagagaaag
    65161 agtggataag tttatcttat caattagagt ggtaacgcgg atatatttcg tctcttggtt
    65221 tttccaagag gcgtttttta atatatttaa ttattagtgt ttatctggta tgttgaacat
    65281 ttactaattg attagctaag tttatcaata agagtggtac cgcggatatt tcgcctctta
    65341 gtattttaaa atactaaggg gtttttttag tattaaaatg attttatgtg agtctaaatt
    65401 ctcagagtca ttcaatatta agaatttcta taaaataaaa attataattt aagattggga
    65461 ggaattaaaa atgaaggaaa aagtagtatt agcatattca ggaggacttg acacatcaat
    65521 cataatacct tggttaaagg aaaattatga agatatagat gttatagctg tttgtggaaa
    65581 tgtaggtcag gaagataaaa tggaagatgt atatgaaaaa gctttacaaa gtggagcatc
    65641 aaaggcatat gtggatgata taagtgaaga atttgtaact gaaactatat ttaaagccgt
    65701 aaaagcagag gctaaatatg aaggaaaata cttattagga acttctttag caagacctat
    65761 aatagctaaa aaattagttg aagttgctca taaagaaggt gcaaaatata tatgccatgg
    65821 atgtacagga aaaggtaatg accaagttag atttgaagct acaattgcag ctcttgaccc
    65881 aactataaaa gttattgcac cttggagaat ttgggatata aaatcaagag aagatgctat
    65941 agactatgct gaaaaacata atataaaggt aacagcaact aaagctaaaa tatattcagt
    66001 agatgccaac ctttggcatg tttcaacaga aggtggagat atagagcacc tagaaaatga
    66061 acataaaaaa gatgtttata aacaatgtgt agacccagaa gatgcatgtg atgtagctga
    66121 atatgtagaa gtttactttg aaaaaggtgt acctaaaaag gtaaatggcg aagaattatc
    66181 tccagttgca ctgattcata agttaaatga gttgggttgt aaacatggaa ttggtgttat
    66241 agatatagtt gagaatagac ttgttggtat gaaatcaaga ggtatatatg agactccagg
    66301 aggaacaatc ctttatgaag cacataatat tttagaaagt gctactttag acaaagatac
    66361 attacatttc aaacaaatgg tatcttataa atacggagaa cttatttaca atggactatg
    66421 gtattgtaaa ttaagagaat ctatagatgc atttatggaa caaactcaag ataatgttac
    66481 aggaacagta aaagttaaac tttacaaagg aaatataaaa cctgctggaa tatttactga
    66541 aaatgctctt tatgatgaag gaatatcttc ttttggaaat agtgaacttt atgaccacaa
    66601 agatgcagaa ggatttatta atttattcac tttaccatta aaaatcagag ctatgaaagc
    66661 tggaaaataa taaaataaat tatttaagag tgtataaaaa cgatttttag gtttttatat
    66721 gctctttttt tatttgaatt tattaaatta tacagtaaat agtataaaaa aatatattat
    66781 agttccaaat ggcttaataa tgtgaaaata taagacctaa aatataaatt ttataaatac
    66841 aatagttatt gactctctca ttgtaagagg gtttatactg aatctaatga aaatttatag
    66901 tgaggagata gattatatga gaaaaataat tgaaattaaa catcattcac atgattatga
    66961 gtgtatgtgg aatggtatag aagatttata tataaataaa accggtgaat accttccaaa
    67021 cgattttttc tttttactgt caggttttgg ttcattttgt tatatgaaaa caaataaagc
    67081 tgatttgaaa agaatggtag ctttgggaga tggaaggaca aaacagatgt ataaattttt
    67141 agcaccaatt gttggatttg aatacaaaca tcatgagttt aaaaagtatg agcaagcatt
    67201 aaagaaagca aaatctgaaa ttgatgatgg atatccagtt attttaggag ctttagatat
    67261 gtattatcta ccatattata agaagctata tcataaagaa catattcctt ttcattatat
    67321 attaatggta ggatatgatg atgaaggaat atatctgtat gattgtggta gaacagaatt
    67381 attacatctt tcttatgata aattacgtga aagcatgaat tgcaattccc ctggattaag
    67441 caaagaaaat actatttgca caataagaat gaatacttca aagaataaat ataacattgc
    67501 tagagaagct attgctataa agcgtgatat gtttttaaat ccacctaaag gatttttggg
    67561 atataaaggt tttgaaaagt ttattaaaga gttgccacag tggaacactg aattggataa
    67621 ggatgattat gataagattt tgaccaatat ggttatgttt tttggaacag taccaacaat
    67681 tccaaatgca atcaaaggaa ttaaagaacc agatactgtt caatttaaag gtggatttga
    67741 taaaatgagt agaatgctca acagtattgg ggaggaatac aaaaacaact cttttataca
    67801 agtagctgat atttttgata aaactgctat tataattgag aaaatatcca atattataat
    67861 agattactta actcaaacat gtgatgatac agaacaactt ccgttattgt tctctgaggt
    67921 cttagagcat atgaaaacag gatatttaat cttggatgta taaaaaatat attgttgacc
    67981 ctaacattac gtaatagtgt aatatgaaaa tatagcttaa atatattagt aggtattgat
    68041 ggctgtaaaa ttaaaatttg aggtgtggat atgagaacag tgaaacaagt ttctgattta
    68101 actggaataa gtgtgagggc attacattat tatgatgaaa taggtctttt aaaaccaaat
    68161 aaaattacag atgcaggata tagactttat gatgatgaat ctattaaaac tcttcaacaa
    68221 attttatttt ttaaggagat tgatattcct ttaagagagg ttaaggaaat aatgtcaagc
    68281 caatattttg ataaggttga agctctaaaa aatcaaaaaa aattacttat tttaaaacga
    68341 aagagactgg atgaattgat agagcttata aatcaaactc taagaggaga aggaaatatt
    68401 gattttaaag agtttgatat gagcgagtat tttaatgttt tagaagaatt taaaagagag
    68461 cataggaata aggtaattaa aatttatggt agtgtagaaa aatacaatga atatatagaa
    68521 agagttaagt ctaatgaaga gaaaattgct aaaatggcta taaaacaata tggaactatt
    68581 gagaagtttg ctaaagctat aaaaacaaat tttagcagtg atatattgaa tttaggagaa
    68641 aaatttgata gatataaaaa tgattgttta aaagaaaaac atccaaaatt aaaagaatta
    68701 tatagaaagc ttgtagaaga tttaagtagg aatccttctt caacagacct tcaagaaata
    68761 gcaaaagcga taacagatat atctaaaaaa gattatgaaa ttttctctat ggatactggt
    68821 gatgacaact ggtattatat ggttcaaaat tatctagtaa atcctatgtg gatagaagaa
    68881 gtagataaaa agtatggaag tggagcagga aagtttattg gacaagtact aaagacttat
    68941 ctaagagata gaaagccaaa gataaataca ttgtatgaaa aacttgtaga agatttgagt
    69001 agagattgtt cttcaaggga agttcaaagc attgttgaag aaatagacaa tgaaatgaaa
    69061 agaagtaatg aattttataa aatagacaat ggtgaaagat actttgatta tatgtcagag
    69121 ctttatttac aagattctaa ctatataaaa gtaactgata agaattatgg tgatggtgca
    69181 tctaagttta ttggagaagc ttttaagatt tattttgata ataataattg ttgaaaattt
    69241 ggaagtaaaa aatatgtaag ttttataaaa gcacaaaaat aaggatgtag attagctcca
    69301 tctatatcct tatttaaagt tattaaaata tatagtttac atcaaactta acactttcaa
    69361 taatatttcc caaatatgtt tttatacttt caacttcttc taaagatttt aatttatttt
    69421 cagtataaat tgctttgtcc agaatattaa accttaatcc tatttcatca aagtactcat
    69481 gatttaaaac tttgtaccaa tggttttttt ctttattcca actcgtagat attgaatcag
    69541 cttctttttg agctttttcc caatcttcat tttctataga tttttctaaa acagatatat
    69601 tgtctttata tccttctgta aaatcatata gtttattgtt aacgtaaaat ccaaataata
    69661 caaataagat agtccatagt ataacaaatg ttgtagattt caatattaat cacccttttt
    69721 attttgaata aatattttgt cattttcatc taaaacacaa ataagaacat ctttaaaagt
    69781 ttctatgtga ttagatttta aaatacccat taaccagtta gtatcttttt gagctatgtc
    69841 tagattttta tttattattc taccatccag tataagtggg ataggtaaat gattaaaagc
    69901 tcttggagga gtactattgt agcttgatgc tggtacaaca cttagattac catcagtctc
    69961 caaaatagca tattgtacat cttttaggtt aaagtatcct tgaatcctaa gttgttctaa
    70021 taattcatct atactaattc tttctttttt aagctcttta tatacaattt ttcctttatc
    70081 tattaataca gaaggtttac ctgataaaaa tgaacttaat tttctgcttt ttaatgataa
    70141 gaatgaaatt agagtctgca tgattacaag tccagatatt gctgcaacac catttatgat
    70201 tggtatatta ttattttcca ttgggacaga tgcaacttct gcaattaata gtgttataac
    70261 taaatcaaaa cagttcattt cagctatttc accttttccc atgactctaa gtgcaattag
    70321 cactgttatg tataatataa tacttcttat taatactact gtcatatcta tcaattactc
    70381 ctttaaaaaa tatttacact tagttagtat atcctatata aaaaatttaa ttcaaagtat
    70441 aaaaaacctt aaataattgg attcaactat ttaaggtttt tttgataatt ttaatattaa
    70501 attttttatg gattttctgt tacttttatt tattttaata acagattcaa caaaactctt
    70561 tttatctcct aattttaaga taaaatcagg atattcttca aattcattga gttttattaa
    70621 tttgaaagaa gaagatagat ttttaaagtt aataatttta gagttattca ctaatacact
    70681 tcttttttta aaataaattt cttttttact tatatttagt atagttaata tttgtttaag
    70741 atatattatt atatcttctg gagttctatc aaatttgagt tcaaaatttt catcttcaaa
    70801 gtagggaata taatataaag gtgttttgag agcaggtaat ttattatata attcttcaag
    70861 aatatcgata tttttagggg agttaaagaa aaagcattta catacattca ttaaatccac
    70921 agcatctgaa agtgagttat gtttaatatc tccttctaca gaaaaaattt ttttcatatt
    70981 cagtaaagat atttgcttag ataagattct attattgtat gtaatatgtt gagatataaa
    71041 aggttgaatg tcaatcatca tattaaataa ctctaagcat ttacctgtat atttatacac
    71101 tctaaatgaa gttagaaggc cagttatatc aaaatcaccc caattatata ttgtaacatc
    71161 atcaaattta caaaaccatt tataaaaatc atccataaca tataaaagat taggagcatt
    71221 attgatatct agttggttca atttggttaa atttttacat ttatttgaaa gtattttatt
    71281 gtattttggc ttaactaaag agtaataatt atctattgta ttaaattcgt tatcaactaa
    71341 aactccacca atagaaatta attccgcacc attatattct tttggtttat ttttattatc
    71401 atctagtata ttaaattcaa agtctataaa taacttgtat ttcataaatc taaagcacat
    71461 cctcaggtaa attatttatt gagcctaagc atcataagaa tcaatagata taatgactct
    71521 aaacatcaaa ggttcattac aacttttatt tatttcataa tttaattcaa ataaatcttt
    71581 taagatataa tttataagta ttctttccca acccattttt aaattaactt tagagtctat
    71641 taatatattt tctatctttt taaatatttc tatatttgct ggtattatac tgagctcaat
    71701 attactttta aacgggttag actgtaaatc tgttataagt atatttttta attcctctgt
    71761 aagttcagaa attaaactat cacctatgta tttttttatg atttcctctc taatttcttt
    71821 taaatttagc aatattagta cctgctactt acatagtagc ttttcctttc cttttaatac
    71881 tattattcat ttttgaatct tatttagata tattttaaga ttaaaagtct ttagctatat
    71941 aattttttac ccatttttaa cttatattaa catattacag gcttatatct ccaccctgtt
    72001 tacattgagg atggagtata ttgcctattt tgataaaaat gataggttgc tatttgccta
    72061 ttcctttttc tgataatttt tctaacatat ctttggtcat tttatctaaa tcataactaa
    72121 acttaaagtt ccattctttt actgcactac tactgtctag agagttaggc caagaatcag
    72181 ctatactttg tcttacaggg tctacatcat attctatcac aaaatcagga atatattttt
    72241 ttatagaatc agctatttct tcaggagaaa agctcatagc agtaatatta aaagcatttc
    72301 tatggatgag tttatcagct ggagcttcga ttaaatccac tattgattga agtgcatcag
    72361 gcatatacat catatccatt tttgtacctt ctgctatgta agatttatat ctcttatttt
    72421 ttaatgcctc ataatatata tcaactgcat aatctgtagt tcctccacca ggaggcgtaa
    72481 cataagaaat aagacctgga aatctaacac ctctagtgtc tactccaaat tttgagtgat
    72541 aataatcaca tagtaattct ccagaaactt tagtcacacc atacatagta ttaggtcttt
    72601 gtaatgtatc ttgaggagtc atattttttg gagaattttc accaaaagca gcaattgaac
    72661 taggtgtaaa aaatttacaa tccaattctt tggctatttc aagaccattt attaatccat
    72721 tcatatttaa gttccaagct tctagaggtt tactttcagc aactgcagaa agtaaagatg
    72781 ctagatgaat tatagtatct acatcatatt tttttgcaat ttcaaaaaaa cgattcttat
    72841 ctgtaacatc taatatctca aatataccag attcacatac tggattacct tcttttactc
    72901 tccttgaact agcgattaca ttttgttctc catactcatt tctaagcttt attgttaatt
    72961 ctgaacctat ttgtcctaat gcacctgtta taagtatttt tttcaatttt acaacctcct
    73021 aagggtttaa tttatgtagt actacttatt tttattttag caaatctttt gtttaaatac
    73081 aaagaattaa agataataat atacgactta attgaatgaa gtgcagtaag tgcgtaaaaa
    73141 tttaaagcta atatataatg gtctattgta taacaataaa aga
//
LOCUS       DAEQCW010000007        71537 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.007, whole genome shotgun sequence.
ACCESSION   DAEQCW010000007 DAEQCW010000000
VERSION     DAEQCW010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 71537)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 71537)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..71537
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.007"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            671..1579
                     /locus_tag="KRO40_000480"
     CDS             671..1579
                     /locus_tag="KRO40_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBH2091319.1"
                     /translation="MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYT
                     KQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVG
                     QEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAID
                     TCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANIN
                     IRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEEL
                     QRPSEEKLEEIKRLFEASNFNTKIGG"
     gene            1584..3953
                     /locus_tag="KRO40_000481"
     CDS             1584..3953
                     /locus_tag="KRO40_000481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HBH2091320.1"
                     /translation="MARGTFERTKKLREESINAEPHISIERAVLMTEAYKKYEGSVEI
                     PVLRALSFKHYIENRTLSINDGELIVGEKGDSPNGAPTYPEICCHTMEDLEVMHNRDI
                     INFSVSEEARKIHKEEIIPFWKKRQTRDKIINAMTPEWLAAYEAGMFTEFMEQRAPGH
                     TVCGDTIYKKGFLDLKKDIEARLKELDFLNDLDAYNKKADLEAMAIACDAMVILGKRY
                     AEKARQMAEEETDEAKKKDLLLIAETCDVVPAHKPETYHQAIQMYWFVHIGVTTELNI
                     WDAFTPGRLDQHLNPFYERDVENGILDRDRAQELLECLWVKFNNQPAPPKVGITLKES
                     STYTDFANINTGGINPDGQDGVNEVSYIILDVMDEMKLIQPSSNVQISKKTPQKFLKR
                     ACEISRKGWGQPAFYNTEAIVQELMEAGKTIEDARLGGTSGCVETGCFGKEAYVLTGY
                     MNIPKILELTLNNGYDPISKKQIGIETGDPRNFQSYEELFEAFKKQLHYMIDIKIEGN
                     AVIENICAKHMPCPLMSTIVDDCIEKGKDYQRGGARYNTRYIQGVGIGTITDSLTAIK
                     YNVFDKKKFDMDTLLKALDANFEGYEAILNLVSNKTPKYGNDDDYADEIMQEIFNAYY
                     NEVTGRPTVCGGEYRVDMLPTTCHIYFGEIMGASPNGRLCAKPVSEGISPEKGGDTNG
                     PTAVIKSCAKMDHIKTGGTLLNQRFAPSVVQGEKGLDNMANLVRAYFNMDGHHIQFNV
                     FDKNVLLEAQKNPQDYKDLIVRVAGYSDHFNNLSRTLQDEIIGRTEQTF"
     gene            4278..5081
                     /gene="proC"
                     /locus_tag="KRO40_000482"
     CDS             4278..5081
                     /gene="proC"
                     /locus_tag="KRO40_000482"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBH2091321.1"
                     /translation="MKTLGFIGSGNMGSAMIGGIVQSELVKAEDITVSDLSQVALDKV
                     KEEFGVNTTTDSKVAVTNSDVVIVALKPNICEKALTPLKELIDANKIIVSIAAGKTIE
                     SLESFIGSDKKIVRVMPNTPALVGEGMSALCKNSNVTDEELNMIKALFESFGEAEIVS
                     EYLMDTVTGISGSSPAYVFMFIEAMADAAVLAGMPRQQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPAGTTIEAVKVLEEEGFRAAVIKSIVACIDKSKDMSK"
     gene            5679..8435
                     /locus_tag="KRO40_000483"
     CDS             5679..8435
                     /locus_tag="KRO40_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2091322.1"
                     /translation="MRDEILSFVNECVLFNNFDELKKESGIITEDIVKKFNLSRTQSS
                     RLLNDLVKSDNLIKINSRPVIFLPKNKINDVVGPTKKSIYENLDELKNECKLLKQETV
                     FNSIIGYENSLKEVIEQIKTAVLYPNGGLTIMLTGESGVGKTFLAKIIYKYSVSSNVL
                     EKNSPYNVLNCAQYYNNLELLSSLLFGHVKGAYTGANESRAGLIEQSDGGVLFLDEVH
                     RLNSEGQEKLFTFMDTGTFSRIGENGVIRKARVRLIFATTESLSEFLQTFLRRIPINI
                     YVPNIEERGTIEKRKIVEHFIYEESKVLGLPIEITQITLNAILKIKFKGNIGECKNVI
                     KYACGRAYAKNQRRNGNIFVTLQDLPRNLYIENVDIFQFQSGKSKSIIFSPKQFSIEM
                     SNGRNKRNIIYQSFIKCLDYFDRLEKNEITKEKFSKKSSNLMIRLMDNLVFSNNDENN
                     NVLMELIISIMQDIFRNLEVNNNIKYDGNNVLAFSSYLYLKDESYQLSDEYKALENKL
                     LIYLKKESYKEYSIISKISTLITNRLDMYLNNVDTIIMIIFIKSTIIRMKFNQVNATI
                     IAHGYATASSMANVCNRMLGKNIFTAIDMPIDATIADVSKQMSRYLEGDRIKNGLIVL
                     FDMGSLNLIFEDLKNKINSPMLFIDQISTISALEVGNLLMQGKNIEEIAEIMDEETKP
                     NIQLYYPQKNKEYAIISSCFTGIGTAIKIQHLLSESLIGIVDVKIIPYDYDSLVSMGD
                     KEPVFEMYDVMAIVGTANPNVNGVDFILLEDIISGKGEDDVFRIFSRVVENEKIKNIN
                     DSIVKNFSLIRVIDSLTILDSKKIIERIEEGINAIENIQKKKLSNDKKISLYVHLSCM
                     IERLVRQTEIEEYTDMDLLIKNHHSEVKLIKNAFSVLEKSYSVQIPISEIGYIYNIIY
                     GLPQ"
     gene            8567..9046
                     /locus_tag="KRO40_000484"
     CDS             8567..9046
                     /locus_tag="KRO40_000484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091323.1"
                     /translation="MVSLMRIDDRLIHGQVAYGWATSLGINVILVANDEAKNDQMKAM
                     SLNLAKPSNVTLYIRGVEESGEIVEKFASSKKSNVLVLVKNTKDALVVAKNSGGVLKE
                     INVGGLRYEEGKKKLTDLVAVDDDDINNFKQIGDLGIDIEFRMLPRDKKKQLSDLIK"
     gene            9062..9484
                     /locus_tag="KRO40_000485"
     CDS             9062..9484
                     /locus_tag="KRO40_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIA"
                     /protein_id="HBH2091324.1"
                     /translation="MKKFLIATHGELSRELVDTSKLIIGSLTNIEYFCMTTDKSADDA
                     EKEIRSILSNNKDSEEFVVLTDVFGGSVANICTNLLLQGFKFELLTGVNLPMLLSILL
                     LVEEDTKLIVKSGLEEAKNGIVYVNELLENQNKIKNVM"
     gene            9524..10315
                     /locus_tag="KRO40_000486"
     CDS             9524..10315
                     /locus_tag="KRO40_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2091325.1"
                     /translation="MLVQATMLAIIAGVGILDGRIFGQSMLDRPIVTGMLVGLVLGDI
                     KSGIMIGAQLELIWMGIAGIGAATPPDVVTGGVLGTAFAILSGNGAEVALAVAVPVAV
                     LAQSLGVLVRIINSYFSQKAVFYAKQADFKKVTIMMWLPVILFFLSTSVPTFLAIMIG
                     ADKVTALINAIPKVILDGLGVAGTLLPAVGFALLMDMLLSKKMSVFFFIGFLLASYGG
                     LDITAIALFGVCVAFVLNFYINNKENNQNPQLAINTLTEGEIDFE"
     gene            10308..11108
                     /locus_tag="KRO40_000487"
     CDS             10308..11108
                     /locus_tag="KRO40_000487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH2091326.1"
                     /translation="MNKLTKKELRSMFWRSFVLQGAFNYERMQNLGYCYSMLPAIKKL
                     YNKKENQAKAIERHLEIFNTTTVVVPAILGITAAMEEENANNPEFDESSISAVKTALM
                     GPLAGIGDSLFWGTFRIIAAGVGVSLAKEGNIFGPLLFLLLYNIPAFALRIFGLKYGY
                     QVGVNSLERIQREGLMEKIMSMATTVGLFVVGGMVATMLSITTPLKFNLNGAEVILQD
                     ILDKIIPNMLPLTFAFVIYYMLKRKVSVTKLTIGTIVTGIALHAIGLL"
     gene            11156..12211
                     /locus_tag="KRO40_000488"
     CDS             11156..12211
                     /locus_tag="KRO40_000488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH2091327.1"
                     /translation="MTIQDYMLETPVRMREIISNADSLFNEVKRTNLKKIIITGSGTS
                     YHSGVQVQPYLQNLLDIDVVKMYPFMITEDTFKFDNENTLVVGVSQGGSSYSTYNAMK
                     LAEDKGCKIASMAGCKNALIDEISDYILTVNCGEEKSGAKTKGYYCTKLNLMLLGLQI
                     AREKGIISSEKYNEEINKILDAINRFEAVYKLSKQWIERNKEKLVNSKEIRIIGHSDI
                     YGDTLEAALKLLETMRIPVTGYEFEEFIHGIYNAINSDSTIFILDTGKEPRVTKMIDV
                     LSGWTENVFAIGRDVTENDKNLKIDITDNPYYQTFNFIVPIQLICGEIPTLRGVDPSV
                     PKDTRFHMKLGSKKLNK"
     gene            complement(12390..14336)
                     /gene="feoB"
                     /locus_tag="KRO40_000489"
     CDS             complement(12390..14336)
                     /gene="feoB"
                     /locus_tag="KRO40_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH2091328.1"
                     /translation="MINVALLGNPNVGKTTVFNLLTGSNQYVGNWPGVTIEKKEGFLG
                     KEIKVVDLPGIYAMDTFSNEEKVSKSYLENEDVDVIVNVVDASNLSRNLYLTTQLMQF
                     NKPIVILLNMLDIAESKGVNIDAKKLSEELGVIVVPIIAKKKNGVDRIEEEIKGATQK
                     AFIYQKNFGSETETYKKLESILSRCTKTTYTQKKSISDKIDNIVLNPILAYPIFIGVL
                     FLLFKFTFDWVGGPLQEGFASLIEAYISAPVSDMLSNSSPWFKSLIVDGIIGGVGGTL
                     PFFPLIFTLFFGISLFEDSGYMSRTAFLMDKVMRKVGLSGKAFIPIVMGMGCSSPAIM
                     ATRTLESEKDRRVTALIAPLMTCGAKLPIYALFVAIFFPHNAALVTTSLYLVGIVMAI
                     VVALFLNKTAFKTEAEPFILELPEYRIPTIDALIKNTWNKSKGFLIRVVTVMFAMSVV
                     IWGLSSFNVFGYTEDINVSFLATLGHIISPIFKPLGFDDWRTSVAILSGLGAKEIVVN
                     SLNILYGNLTVVLPTIFNGVTAYTFLIFTALYTPCIAALATMKKEYGNKMMFTSFAYQ
                     FILAWIMAFIVKSIGGVLFMGNSIIEALIGGIIIVLALFILFNKFKSTKNGNVCSGCS
                     ICSGCPSANSCSSKEDSNKKNNAH"
     gene            complement(14354..14572)
                     /locus_tag="KRO40_000490"
     CDS             complement(14354..14572)
                     /locus_tag="KRO40_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH2091329.1"
                     /translation="MTVYDLKIGEKGFINSIDGDIKLSKRLLALGCINSTEIEVKKVA
                     PLGDPIIIRFRGFDLAIRKSDAKNISLQ"
     gene            14778..15287
                     /locus_tag="KRO40_000491"
     CDS             14778..15287
                     /locus_tag="KRO40_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gx transporter family protein"
                     /protein_id="HBH2091330.1"
                     /translation="MKTRKMTFLGLMIGYSLALYVLETYIPNPLIVIFPGAKLGLSNI
                     ITLISLMLLGVKDTVIIVTIRVILSSIFAGPLSYLLFSIGGAYLSLLFMYLASKIKDL
                     SLIGISIIGAIGHNIGQLIVASLIIENILAIGYLPFMLMASLVTGMFVGLVSRYTIPK
                     LKHFYSKFY"
     gene            15365..15526
                     /locus_tag="KRO40_000492"
     CDS             15365..15526
                     /locus_tag="KRO40_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="HBH2091331.1"
                     /translation="MANNELEALKNEIEAVREEINTYIEYPEIFQEELVESSKKIDIL
                     INKYMYLSK"
     gene            15677..16342
                     /locus_tag="KRO40_000493"
     CDS             15677..16342
                     /locus_tag="KRO40_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBH2091332.1"
                     /translation="MIDIGSKEIAIRLLLALIIGGIIGLEREKIRQFAGFRTHILIAI
                     GSCIVSITSIQLFFDYNLYTNADPARMPAQVLSGIGFLGAGAILKNKGGVKGLTTAAG
                     MWATACIGIAVGYGYYELAILGGLFVMIALFVLRIINTFLFSQEKNVLILKLSNLDSI
                     PFLYDKFEKNQLIVRNMEIECRNEEYWKVNFFVSYAKRIHLHDVMKEINMIEGVINVD
                     YLD"
     gene            16408..18192
                     /gene="pepF"
                     /locus_tag="KRO40_000494"
     CDS             16408..18192
                     /gene="pepF"
                     /locus_tag="KRO40_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBH2091333.1"
                     /translation="MGTDRSTIEEKYKWKIDKMYSSKEEIEKDISKVKNLIQEVKEYK
                     GKLSESKENLYKVLNISENASRIVQNLYVYTHMKQHEDTRINDNQGRATKTEMLSTDL
                     GVATSYIVPEILAIEENKLSEYLKDEKLSFYTKYIKDILRDKPHTLSEREEEILAATS
                     ELSTIPENVYDMLAYADMEFPEIEDEEGNKVKLSHSNYSLFIKSKNSRVRKDAFEGEF
                     STYEKYKNTFASTLYGGIKSEIFYAKTRKYNSAIEASLFSDDVSLDVYNNLISAIDKS
                     IPNLNKYVELKKKFLGLNEIHMYDLYVPLTDKFDMDIPYDKAQDIILEALKPLGEEYL
                     KVIKSAFDEGWIDVYDNEGKKGGAYSWGSYDSHPYILMSYKNDLNSLFTLIHELGHSV
                     HSHYSRTSQPFLYSDYKIFVAEVASTLNELLLINYLLENSKSKDETIYLLNYYLEQFR
                     TTVHRQTMFAEFEKIVHQRVESGEPLTADEFTNIYYKLNEKYYGKSAIVDKQIGIEWA
                     RIPHFYSNFYVYKYATGFSAASALSQQILSEGSTAVDRYINFLKSGGSEYPLEQLKSA
                     GVDMTKKESIEEALNVFAELVNKLEKEL"
     gene            18444..19286
                     /locus_tag="KRO40_000495"
     CDS             18444..19286
                     /locus_tag="KRO40_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2091334.1"
                     /translation="MFKKKIGVLLASTMLVGALAVGCSSNSGGSGDSGDSSKVSVSGS
                     TSIGPLMETIGEKFQEKNQGVSVEVQQIGSSGGIKNAIEGTSEIGMSSRDLKDEEKSA
                     GLKETKIAIDGIALITNTANSVKNLTMDQVKGIYTGKITNWKEVGGNDAPIVIVSREE
                     GSGTRDGFQEIVGFDSEELTKDAQISDGSGNIKTTVEGNENAIGYISFGYVDEKVNSL
                     KINDVEATDANVIANKYPISRPFILVNKEDGLSEKGKALIDYILSDEGQALVSEKGFI
                     KVNQ"
     regulatory      19519..19602
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            20182..20859
                     /locus_tag="KRO40_000496"
     CDS             20182..20859
                     /locus_tag="KRO40_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091335.1"
                     /translation="MYNLLVVDDDVDILNINQIYFSNIGFNVYTSETAKDAMDIVESI
                     VLDCIILDISLPDIDGYKMCNDIKEKVNIPIIFLSNYEHEEEKVRGFLAGGDDYITKP
                     YSLKELELRIYARMRQYKNITSVPNVLKFSALVINVNSRKVTFDGESIDLTTMEFEIL
                     LFLAENKEQVFSKIEIYNQVWKMPDIGDQHTVQVHIAQMRKKINSLSREHQYIQTVWG
                     KGYKFVP"
     gene            20931..22946
                     /locus_tag="KRO40_000497"
     CDS             20931..22946
                     /locus_tag="KRO40_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH2091336.1"
                     /translation="MKKYNILKGTLIVLIVSLLAITGLNLLYKYDNKYTYKSIRASNG
                     ILTIDNDTFTKGQLVFLIDDWEFYNHKIFKPNDFTEQDIKPEYVFIGQYPDFSMRKGN
                     QSPYGNATYRMRIKNEGKDKLLSLELPEIFSASEVWINGEMVSKLGDVGTEKYRPKIK
                     NSVVSFIAKKNTEIIINVSNFSHYYSGLYYPPALGETKDISNMMFYRLLFYSIICFTT
                     FAIAIFSLSVWFLSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSY
                     FMVVLCIICINGSISKIEENKVYRFLILPLGITMSIISIVIPIILLPYDMYFVNIYGK
                     LIDIYKYIVFIYILMSSLVSIYKKTCSEHISSYILVSVNTVFGISILFDAVTSNRFEP
                     IFTGWQTEYCGFVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNER
                     KRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQKSNEVQNRVRSLQ
                     EFTSQDKSIGISEKICLNNFIKEIYENNLPDTQACGVNFEAYVLEKKIYAKINKEMLT
                     RAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTER
                     DNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSLCFL"
     gene            22996..23676
                     /locus_tag="KRO40_000498"
     CDS             22996..23676
                     /locus_tag="KRO40_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091337.1"
                     /translation="MQTKILIIDGDKDNCQKLKGFLEEKGISIDLAYNCEEAIGKIFS
                     NKYDLIFLEIILSDGDGWTLCKKIRNVTTCPIVYMTYINEDQSILNALNSGGDDYLIK
                     PLNLEILYAKVKAILRRMNSYVNNNENNTKLEEYNRTSGVIKLEDKIIKLTPTENKLL
                     NFFIENPEKTLTTKEIYEHVWMNEYLEDNYSVVVAVNGLRKKIEKDYKNPQKIITIRG
                     AGYYFNKE"
     gene            complement(23827..24945)
                     /locus_tag="KRO40_000499"
     CDS             complement(23827..24945)
                     /locus_tag="KRO40_000499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH2091338.1"
                     /translation="MNIKSAFIRKRGEKFHVYVEYIEETTGKIKQKSYGSYEKKKDAE
                     KHLIEIKSTINNNKFITPNKITLVERCYKYIIANEKNWSPYTTVNRKSWVNNYIEPFF
                     KDIKLIDINPSLLQFFINKSFNNSTSSSAKVRYNFLSSVLKEAYRLKEISENPCDFVK
                     LPAQNVTYEIEIYNREETLLLIEKLKDSLIEIPILLMLLLGLRIGEVAGLRWSDVDLD
                     NSIININQILIYANSKITFKEPKTAKSKRTLSVPKELIEKLKIEKLKQNKMKLQGTLE
                     NENNLVCLNTNLKPWIPTALSKTFHNFIKRNNLRNIRVHDLRHTNASLLLLGGTNMKV
                     VSERLGHTDIKITMNRYSHVLEEMDKEASDNLSKLLFK"
     gene            complement(25459..27123)
                     /locus_tag="KRO40_000500"
     CDS             complement(25459..27123)
                     /locus_tag="KRO40_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4041 domain-containing protein"
                     /protein_id="HBH2091339.1"
                     /translation="MNNENEQLKSDLLINDEKIKNLNFKIPWYYSLWTISILILSTFS
                     TYSISFIVAIIFLFKRNKIMKKHKDSISILLSDVEKINNKYILLNDEIKMKEKHFEDL
                     CESNENKLKELSNLLDKKKVEIDKFDSENQDKFKLIEELKIEKERLDNLIKDKNILKD
                     NINTLNSHLEELKNEREELRDINTTLKNKKEELKRLSEELIQTEDEVLLQSFGLYNPK
                     YDFENSDEYMEKLKEIREMQKLLIRNKTGVKYSDSWTVDGSVQKGRTMTNQNIKTALK
                     LFNSECDIAMSKVSFKNIDSIEKRIRKAFTDTNKLNTSNKVSIKENYLNLKIDELYLY
                     YEYLQMKEEEKEEQRALREQMKEEALVQKEIENQKRKLKKEELQFKNELLRLKSTIPE
                     DENDKLEWEQKINSIEEKLALLSKDLDDVLNREQNTRAGHVYIISNIGSFGENIYKIG
                     VTRRLDPTERINELSSASVPFKYDIHATIFSEDAPKLESALHKAFDNKRVNKVNNRKE
                     FFKVTLDEIRTEVEKNFDKTVEYTKLAEAQEYRQTLKIQELNNKLA"
     gene            complement(27394..28842)
                     /locus_tag="KRO40_000501"
     CDS             complement(27394..28842)
                     /locus_tag="KRO40_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAP domain-containing protein"
                     /protein_id="HBH2091340.1"
                     /translation="MSILNLFRKNKNKNNVDCNEKSNESKQSYNDSTTLSLECNSNSP
                     HNIEVKNEINKVLNVSCNDTTNLYELEKQAREKSDALYDIHTNSINKFNPQNNILETD
                     TKPLTSIEKSFLKYIIGENIYEPYIATYWTYEYNINYSYLISKFFNMDYLKISNYIED
                     LTKLTVSELKEILKSNNIKSTGKKAELIERIEKEISCKDLSNFFNSSNKYYALTDKGK
                     ELLKDVRKSVTKNTDLEDQCLELIYIDKYEEAYDLICKYESSKNIQRGININWENHKI
                     TPMKIESYKAIKELDINLKDTLLDNIIKSSYILCDMLGNNSKTSILVKRLAGEKIDNI
                     EINNAINSINDVIYNHSTITYNANDSINNKNLHYMDIVKNNKSIPFEVNNKNYNFKIN
                     ENEIYFFNILKIKMYENELKNNFVFDRMSDGAFNVFDTSDNFIGKVKLQGRKKWIMYM
                     KNEFGSEHIYGELIHLIDGIDAWIKYSKEYLK"
     gene            29338..29478
                     /locus_tag="KRO40_000502"
     CDS             29338..29478
                     /locus_tag="KRO40_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091341.1"
                     /translation="MEKSKKLLIDTGDTLNKLRENNSEKLEKYIELLKEYYKQENKKE
                     RE"
     gene            complement(29493..29858)
                     /locus_tag="KRO40_000503"
     CDS             complement(29493..29858)
                     /locus_tag="KRO40_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091342.1"
                     /translation="MIGYRIKELRKEKDITQKELATFLGLTPKMISFYEKEERFPPHD
                     IILKLSDFFNVSTDYLLGKVNVKNIDNLSELELIENLNFSDDIKEALKLISELSPSSQ
                     EKMFKIAKVFLEEELNEKK"
     gene            30003..30239
                     /locus_tag="KRO40_000504"
     CDS             30003..30239
                     /locus_tag="KRO40_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091343.1"
                     /translation="MNKLKDFRIQKGLSRNQLGAELGLTSRYIAFLENGERVPSLNTA
                     VKIAAYFNTSIEYIFLKNNCTKSTFKEKGAEKYE"
     gene            30232..31023
                     /locus_tag="KRO40_000505"
     CDS             30232..31023
                     /locus_tag="KRO40_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6N domain-containing protein"
                     /protein_id="HBH2091344.1"
                     /translation="MNNLQVIERNNERVLTTQQLADVYETDARNISNNFNNNKDRFIE
                     GKHYFLLQGDDLKNFKGIHTEYENLKFTSKMYLWTERGANRHCKILDTDKAWEQFDNL
                     EETYFKVKQHKPTCIEDVLIESLKEMKDLRLQVNQANSIALEAKTEVETIKDVVSLDS
                     NSWRTNTHQLIARIAKKQGGFEHINMLRTESYELLNKRFGVDLHRRLINKRRKMAEEG
                     VSESKREKVNNLDVIQDDKKLIEGYVAIVKDMALKYGISSDLSKN"
     gene            31093..31422
                     /locus_tag="KRO40_000506"
     CDS             31093..31422
                     /locus_tag="KRO40_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091345.1"
                     /translation="MSVALQFIDTEDLVKELMGREDTVDFIKMFLDREGIKRMELMTI
                     EEFCEYLKISDVTARNMAREAMITKDFIALKIGRKYMIDRISFEEFIMKNAMKDRDVM
                     KKRKGVI"
     gene            31555..31737
                     /locus_tag="KRO40_000507"
     CDS             31555..31737
                     /locus_tag="KRO40_000507"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091346.1"
                     /translation="MEVTKRFLEYKIQALSERIEFKKTIGYKCIADEKELGAYEDILL
                     MLNSEIESIGGVENEE"
     gene            31727..31972
                     /locus_tag="KRO40_000508"
     CDS             31727..31972
                     /locus_tag="KRO40_000508"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091347.1"
                     /translation="MKSRQELIKDIEKYRKAQYLIYLDIVQRAWADRSLTADEQDRIK
                     QEAYAEYKRIERDTEEAEELLMREEFETDRPLAVQIM"
     gene            32055..32564
                     /locus_tag="KRO40_000509"
     CDS             32055..32564
                     /locus_tag="KRO40_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siphovirus Gp157 family protein"
                     /protein_id="HBH2091348.1"
                     /translation="MSTLYELATDLLEIEEGLTETTRNEAEKLEEIKEIIKQEIQNKN
                     TRIVSVILNIDSDINSIDSEIKRLQELKRVKKNTLDRLKSNIKDCMELLDTKKVETFL
                     GNISIRKSAGSLVIEDEEKIPAIYKTVEQVVKVDKNTIKDFIKKGHEVEGCRIEYSTT
                     LTTPKVKKE"
     gene            32574..33182
                     /locus_tag="KRO40_000510"
     CDS             32574..33182
                     /locus_tag="KRO40_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ERF family protein"
                     /protein_id="HBH2091349.1"
                     /translation="MENNNIYIKLVNIQSTLKAPKSQFNSFGKYNYRSCEDILEGLKP
                     ILKEEKALVILDDNIVQIGNRFYVEATATLIDAETGEKVSTKALAREDETKKGMDLAQ
                     VTGSVSSYARKYALNGLFCIDDTKDSDATNKHGNEQKKKEVNESELNTLYSLGESIEK
                     DKNRVDSEVYKKFGKLAVDLTKQEYEKVLNGYKSILEKQKQE"
     gene            33192..34073
                     /locus_tag="KRO40_000511"
     CDS             33192..34073
                     /locus_tag="KRO40_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBH2091350.1"
                     /translation="MGIIRVSKDKDNPYVVLNKTCLEDVKLSWQAKGLHSYLISKPDH
                     WKIYVNDLCKRSKNGRDATANILKELIENGYITRKPCRDSNTNKMLGGYDYEVYEIPL
                     ENPQKLKSRKTDFPETGFPGNRVSRKPENTEVVSNDFKVNNDITTIVINEQSNKDKTT
                     YIKKYFEKYIGVITPNNFIELMSYLDDGMEADVIIRAIDEAIANGVKNYKYVKTILNN
                     WIEAGVKTNLELTEYQNEFERKKKNKQDKKQSNSKAVNTPNVSKNKFHNFNETFTQYS
                     PDELDDIIKKSQKVKFK"
     gene            34132..34305
                     /locus_tag="KRO40_000512"
     CDS             34132..34305
                     /locus_tag="KRO40_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="resolvase"
                     /protein_id="HBH2091351.1"
                     /translation="MARIYAQRSGSLNEQDRLELLRLLGKAGYTVKIAREKQNSKTTY
                     TYFVEYTEEQEEK"
     gene            34321..34737
                     /locus_tag="KRO40_000513"
     CDS             34321..34737
                     /locus_tag="KRO40_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH2091352.1"
                     /translation="MNTITLVGRLVADAELKYLPNSGTPKITFSMAVDRRFKDKNGNK
                     ITDFIQCEQLGKHVENLVQYLVKGKPIYAVGELNIYNYKDENGCWKSITKVNVNALEL
                     LSSKSDSNNHKEQQEYIPPGLDPQGFQAIDDDDIPF"
     gene            35071..35328
                     /locus_tag="KRO40_000514"
     CDS             35071..35328
                     /locus_tag="KRO40_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091353.1"
                     /translation="MIIIRSQNKLDLMRVNRVEIDSRYVYAVFEGESNVREIGRYKSE
                     ERAIEVLNRIQEAIIAGTKFDIINKDGVRCNKEKVFEMPVE"
     gene            35342..35707
                     /locus_tag="KRO40_000515"
     CDS             35342..35707
                     /locus_tag="KRO40_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091354.1"
                     /translation="MLKVERYFSGSVADNIFEDDLTLRNYLALYCCIYGVNKNGELVF
                     PTRGKMLIEFNVDRDRKKRKKASKVKLINVKTGEEKIFDSIDSAACFLRLQSQAVYQT
                     IKKKTKTRSGWKAEYIEEE"
     gene            35825..36160
                     /locus_tag="KRO40_000516"
     CDS             35825..36160
                     /locus_tag="KRO40_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091355.1"
                     /translation="MNILASVILVIGSFIAGRVYEYRLNLNENDEADSKVLLDVFNEI
                     SVLREENKSLKEKLQEKELLFINRLIDFLHDKKICECCIYDCKIDDIEYDCEDGIKKW
                     LDSEELIFE"
     gene            36268..37341
                     /gene="dcm"
                     /locus_tag="KRO40_000517"
     CDS             36268..37341
                     /gene="dcm"
                     /locus_tag="KRO40_000517"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HBH2091356.1"
                     /translation="MLTFLDLFAGIGGFRLGMEKAGHKCLGHCEYDKFANLSYNAMHK
                     PKEDEWFERDIREIRTENIPRADVWCFGFPCQDISVAGKQFGFRGERSSLFFTVTKLI
                     RELKEEDRPKYLLIENVKNLLSVNGGFDFLKVLVELDEIGYDAEWQVLNSKNFGVPQN
                     RERIFIVGHFRGRSTRKVFPIERKSGKNLEQLNNPTHSTNRIYDAVGIARCIRSQAGG
                     GGAKTGLYFIDLNKNSKITINARYLKTKYNAGVTNRNCDNSGVLVNAVLTPDRVNKRQ
                     NGRRIKESGEPMFTLTAQDKHGILKNGDIRRLTPKECFRLQGFPDKYYERAASVCSDS
                     QLYKQAGNAVTANVIYEIAKRMG"
     gene            37423..37653
                     /locus_tag="KRO40_000518"
     CDS             37423..37653
                     /locus_tag="KRO40_000518"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091357.1"
                     /translation="MQKYKIKFEEKVTLEHEVIVEIPEEISINDICHCIEQKCQRIYD
                     IADYIREFNGRQIDFTEDTCGGTEMLVESFRK"
     gene            37908..38093
                     /locus_tag="KRO40_000519"
     CDS             37908..38093
                     /locus_tag="KRO40_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091358.1"
                     /translation="MVITEFKVTWQTTREWEKGNVYSSIFTNLEEARAFKKDEENIKE
                     NYNVKLLSRAIVEIEID"
     gene            38107..38346
                     /locus_tag="KRO40_000520"
     CDS             38107..38346
                     /locus_tag="KRO40_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091359.1"
                     /translation="MNTLIYKYIVNEHRDEADELDRDYGEFKIFNGGKCFGGCGRNFY
                     TLAKFKKMIVTCPHCGKKYQIKLFKNGKVNMRVIE"
     gene            38475..38882
                     /locus_tag="KRO40_000521"
     CDS             38475..38882
                     /locus_tag="KRO40_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBH2091360.1"
                     /translation="MKVFLVIDGEPVGKERPRMNSITKRIYTPNKTRDYEELIKWLYQ
                     SKVKYRFTGYIKMTLRCYYSIAKSNSKKVKEQKRNNVLRPSKKPDIDNVVKIIADSLN
                     EIAYKDDTQIVEVVASKYYSDKPRVEVILEDII"
     gene            38897..39622
                     /locus_tag="KRO40_000522"
     CDS             38897..39622
                     /locus_tag="KRO40_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antA/AntB antirepressor family protein"
                     /protein_id="HBH2091361.1"
                     /translation="MNEIMTNENLRVVADDLVTVYETDTGEKIVFARELHNNLEVKRQ
                     FIDWIEDRIKQYGFKENEDYSVFHKNMKNSTGGRPSKEYVLKLDVAKELAMVQNNNKG
                     REIRRYFIRLEKLLNRTLSNSQLSQINTIVNESLLKMEVKHNIQIEQLKKECSEYYRP
                     TSKTKYDISSYIKERLGISKVNEEFELVKKRTLLVLGADKWEDIPKDVLLNSLNLIDE
                     SIRIIKSERKTNQISFFEKDNFC"
     gene            39716..40204
                     /locus_tag="KRO40_000523"
     CDS             39716..40204
                     /locus_tag="KRO40_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091362.1"
                     /translation="MDNNINKKELFKKVEGRLHHYKFLSAEIKNLELDIESRENEIFG
                     CKAVGYDEKVSPTYAFNSSVENEIIKKERDITRLKKLKKDKEIEKKKIENALTCLDIR
                     EEHFFKLFYNSRMKNSMVYISLEMNSDRKTCRCVRERLVYKIMDMLYPRIKENELPLF
                     KN"
     gene            40655..40852
                     /locus_tag="KRO40_000524"
     CDS             40655..40852
                     /locus_tag="KRO40_000524"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091363.1"
                     /translation="MSNLREKIIKELNEFNIKADNDFLEYAVEHIKKFMNEGIADEEL
                     LIRGVVLGASYVVNIENKDLD"
     gene            40899..41156
                     /locus_tag="KRO40_000525"
     CDS             40899..41156
                     /locus_tag="KRO40_000525"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091364.1"
                     /translation="MNDYKEKTEPKLNILVQSKVDILCSNSSTMNGVDTSIDIKLSLD
                     NRVIGNLTNEDIKKEISTSFNKCLKEIDKKICSKEVINKLI"
     gene            41327..42028
                     /locus_tag="KRO40_000526"
     CDS             41327..42028
                     /locus_tag="KRO40_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091365.1"
                     /translation="MQDVKEKVKQDYLKGMKQKEISAKYDISLNTLKSWIKRYNWANE
                     KKKGAPKNKRGAPIGNKNATGPPGNKNAEKFGFFSKYLPEETRELIQEISIKDKFDIL
                     WEQITIQYAAIIRAQKIMYVKDKEEMIKELKKHESTENGEKIEYEFQFAWDRQASFLN
                     AQSRAMSELRSLIKQYDEMIHKDWNLATEEQKNRVEKLKCEVDNLKKSDTGDDSKIWV
                     EAIQNIAMKRGVNNG"
     gene            42021..43430
                     /locus_tag="KRO40_000527"
     CDS             42021..43430
                     /locus_tag="KRO40_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="terminase B"
                     /protein_id="HBH2091366.1"
                     /translation="MDKALLTLLDCYWDNPVWFAEDMLNFKADKWQSDVLMALAQTPK
                     VSIRSGQGVGKTGLESIATVWYLSTRPFPKVVATAPTRQQLYDVLWAEIAKWLSNSKV
                     EKLLEWTKTKVYMKGFEERWWATARTAVKPENMQGFHEDYMLFVVDEASGVADPIMEA
                     ILGTLSGAENKLLLCGNPTRTSGTFYDSHNRDRDLYKTFKVSSLDSPRTSKDNIEMLK
                     RKYHEGSDPWRVRVLGEFPKGESDSLISLEAVETSTIREVNISNDYILNIGADIARYG
                     DDETIIAPRIGGKVFDLLTYSKKDTMETVGNILRAVDKFKNMYHQINRVKIKTDDDGL
                     GAGVTDRLKEVIRHERLKYEVIPIQNGSSAIEKDKYYNKASEMWDNMREELDANLSSF
                     IQNKEAIIQLPNDDKLIKQLSNRKYTVDSKGKIQIESKKEMKKRIGESPDRADAVIYS
                     FAENNNTDLSLLKGGSVWG"
     gene            43421..44923
                     /locus_tag="KRO40_000528"
     CDS             43421..44923
                     /locus_tag="KRO40_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH2091367.1"
                     /translation="MGIISYVKKLFKRPAGEIMRMSSGNIGVYKLDDSRVDYELAREL
                     YQNKNAKYKLGSSFVRPIVNSTTGFMGVPHFQIEDEEAQYILDEFVLDNTSKMLKTHT
                     DSLKQGDCYIWITREERENPLYPDKKVRLIYNFISPEEVKEIILDPTTKEPIAYILES
                     QNEWTDLGENKRKAKVKQIITAESRFVEVEGDKIEGLEEGETPNVWGFIPIIHFKNEA
                     DETLKYGQSDIEPIEPLLKAYHDVMLHALKGSKMHSTPKLKLKLTDVASFLAHNFGVE
                     DPVKFAKEGGKINLDGHEILFLNKDEEAEFVEVKSAIGDAKELLKLLFYCIVDVSETP
                     EFIFGVHTPSALASVKEQMPIMVNKIRRKREQFTNSWQLLARMVLIMSSNSSGMKYSS
                     YDVTIGWDEVNPRDDKELAETLEKVCSALDKALEGGFISEESTVNFLAQYIDTMSNYI
                     SDDPEIVGEREKIIKTKMLKYRLDDSQGLNDESNEIEKEINKIKDNNGNG"
     gene            44910..45923
                     /locus_tag="KRO40_000529"
     CDS             44910..45923
                     /locus_tag="KRO40_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091368.1"
                     /translation="MAMDKSTSELITVAGEYKKWALEARKKFIDLRLKQDDEIRTMYI
                     NITRNITKEIRKGNLSDFNKVRLKQILKQLTQEIKILNEQLVFNFDEYLNKNVETATS
                     YSKNILINAVETAQITKVTKTMIQKAFYDINIRTVEAYYTRVKDGLFLSDRIWSKCKK
                     YREDMKVILQTAVTEGQDCVKTAKMLDKYVLKGKKTLVDEYPNMIKRIGNRVPQNISY
                     EALRLARTEMTSAYGDGVLASAMINPATIGIQFMLSMAHPHTDICDEICGEDNFGLGK
                     GVYPINEAPVYPFHPHCLCIMLTVVQPLDILVGRLKNWIKNPMNDVPLEMWYQEVYGN
                     LNF"
     gene            45943..47277
                     /locus_tag="KRO40_000530"
     CDS             45943..47277
                     /locus_tag="KRO40_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091369.1"
                     /translation="MNVITGEMDSMNALISSIKPSDIPLAKDIDIEALKSIDDDPLEV
                     VVEIPATKSKRGWNYTAKSLKDIVDYTNENTLNGFLGHQKAENISTEFALPVTHWIGA
                     EMKGDKAYFRGLIDADATNLKRWIRTKRIKEVSIFGYPKLKKSAKGEMNVIGYEPLSI
                     DWTPLHRPGMPTSIVGMEMSPNGEQLDGTFEALRIDLREALKAKFSINDNNSYLYIQN
                     IRYDNNTVIYELEQNGLCKLYSIPFTIVENKINLGEEIEVIKKISYEAKGEMKGEENK
                     LEGKELIKNVKGLLQTGEISYSEVIQGIGLTKEIVTGEMEDVKSSLKAEKELREVKKV
                     LGIVGEMDTVEVAKKASKALENEKKEAWNCIVNKVIKDKVSGEIAQTLVKKMLNVEEG
                     SSEEVITGEIENILNDEFVKNTMSNMYKDNPTTTGLLNSSNNGSLTTKKNRI"
     gene            47293..47676
                     /locus_tag="KRO40_000531"
     CDS             47293..47676
                     /locus_tag="KRO40_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2190 family protein"
                     /protein_id="HBH2091370.1"
                     /translation="MAFKGQPTPSTITQITRAKISDGKSVRVILSEGESTKTQQFYLI
                     NGFFGVAMQDGEKGDEVTLQIEQAEYETDNIVTSEAFEAGKLIYWDNTAKKFTTTSAS
                     NRLVGRVTDGKDSNNVIWFILLPQQ"
     gene            47695..48732
                     /locus_tag="KRO40_000532"
     CDS             47695..48732
                     /locus_tag="KRO40_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate ammonia-lyase"
                     /protein_id="HBH2091371.1"
                     /translation="MAFKVISQENLLEQKRKETLQEDIPFIVNGEMEYVTKKISNGEM
                     ETLELNKPLGEMMTFSSTSNLKELLRKVVLDVELGREQVQLLYKPIYDSIADSNLPQV
                     MDAKWALQGNCVFLEHIEGEEIKFGTINAENGPVARIQTYATGFEYTKEMKDFNQTFS
                     VEILNKSIGESYNALLNHIHLSPIINFNYKASNKTAFKGETNDPIWLGIWRTLTQAQK
                     DTVIAKRQGNILMASSADQIEIEMALNGGHLLNGSMYPSIKNISTVIYYDGWEVTVGK
                     KTYSYKGVTPGKGYLIRPKRGFKELIKRDLTTEVGNADLSKLVENQIVGHCYRGAFAA
                     VEENVQEISFR"
     gene            48772..49110
                     /locus_tag="KRO40_000533"
     CDS             48772..49110
                     /locus_tag="KRO40_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091372.1"
                     /translation="MTPTSNLIEKLRLLLNDKDKKSFTDEELNLFLEEADCIYCAASQ
                     GWVLKSLQYENTVGEMYEYKVGQETYKSSSIKDLVSVAYQNAEKFKDMCTNKKEKGSF
                     MLGISTEFEI"
     gene            49107..49484
                     /locus_tag="KRO40_000534"
     CDS             49107..49484
                     /locus_tag="KRO40_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091373.1"
                     /translation="MINIDRRRKDIIRTINMNPTNITITNIKKTEIDGAFEETETEIK
                     CVVRIFNEKTAEKQISSEKQGTFSSIRTYGMLVSDDVVLDVNSRDSLEFECIYGRMKI
                     VNVYPQIVKGELCGYQCSLERID"
     gene            49486..49896
                     /locus_tag="KRO40_000535"
     CDS             49486..49896
                     /locus_tag="KRO40_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091374.1"
                     /translation="MSAFTNAINDINRKKAGMFVLCMSASAMLEGEAKANASWTDRTS
                     HARQSLNAKTLGGGNNFIIRLSHGAEYGGILEEGSKPHVITPKSAQALYWRGASHPVK
                     SVQHPGTKAMPIIKPTIDKNIGKIGNMIFRYWSD"
     gene            49899..50075
                     /locus_tag="KRO40_000536"
     CDS             49899..50075
                     /locus_tag="KRO40_000536"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091375.1"
                     /translation="MKYTLANIRPLNNFLDFNLESFEILTKKMPIDILKPKVELISLD
                     YGEVKLIKKYTDCI"
     gene            50093..50914
                     /locus_tag="KRO40_000537"
     CDS             50093..50914
                     /locus_tag="KRO40_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091376.1"
                     /translation="MRAGIRKALIDNIKELKGCYEPNVPNKDTKKPYMVVVQGQDNDN
                     GETIGFERSIEIWIYEGRTTFKKLDKLTKQVVEVLDMNTIVDESENEAFTCIYKGTSE
                     NDIVVEEWDAIARGIRFSVIALEDKEDTTNDRWVEALSKYTKDLLEIESYKENWKKNF
                     IAPCALWRTTNVENKRINYHLIEITKTMKCHVVSKNKDEIVKFLEALETSLIIDKRVR
                     LREDKNMYLTLVSVVEDRESDMFTTGQLTVVFKMIGKIKREGPIMDKIYSNGNLK"
     gene            50927..51130
                     /locus_tag="KRO40_000538"
     CDS             50927..51130
                     /locus_tag="KRO40_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091377.1"
                     /translation="MAETINKKTNVSKQEEKYLKNDFLKNSEALGYEKMVVAGALFNC
                     KKEELTKSEFEKLIKDFLEREVK"
     gene            51132..52553
                     /locus_tag="KRO40_000539"
     CDS             51132..52553
                     /locus_tag="KRO40_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath subtilisin-like
                     domain-containing protein"
                     /protein_id="HBH2091378.1"
                     /translation="MATGTWNEKEKKEIPGFYNRFKTQAEKSANTGLKGRLAIPVKAN
                     WGEVGKVVTIKNDLRQLKTLFGDDMNYSAYKLGKLALLGNVKELLLYRLVDGKQKKGT
                     LTLKDTTENSAKDVIKLETKYPTARNFNVTIKSNLVDSDKKDFIFFENTKQLFSSSIK
                     GTIDEIVLEINSNLDNEYVIATKVADSDTILANVVNQALEGGNDGCTSITNESYLKAL
                     EEFERYSFDSFVLDGVAEEALQETTKAWVAKNKELGKDILLFLGGKAEDNIKQINDKS
                     KSFNDENIVNVGSSAYYEGIKYTPSEVAVYIAALSVSKGITGSICNAKTIFEEVEPRL
                     SQSEVKECLKSGTLILDFDDGDVIIVDDVNTFKKYVDDKNEAIGYISNIMFINTINKD
                     TSLKRKEFVGKIFNDSTGQTTVICALKKYFEELMGQGIISEFNVDIDTELQATAKADE
                     FYWKWDAVKVDVMKKIFGTGYLG"
     gene            52569..52991
                     /locus_tag="KRO40_000540"
     CDS             52569..52991
                     /locus_tag="KRO40_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091379.1"
                     /translation="MGKYDENIIDAANVADGSNAKIIVDGKEEGYGTEFTAEVENDKK
                     TFRVIGCKWELNKASTQKGTFSLTVLKTTSEWIERGFDKFELISEIENPGLVGYERIR
                     YKNCMVDKIQLASIKADENIEIQIDGTFEGYELVDKIA"
     gene            53070..53543
                     /locus_tag="KRO40_000541"
     CDS             53070..53543
                     /locus_tag="KRO40_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091380.1"
                     /translation="MANLDKEFLNEGIEEERELTKEEIAKQQEDNIIMKLTEDAILPE
                     KTIFVKRLDIPLTLRALTEKEISALQKKYTKVTKVRGRRESKLMEDEFNIALIEKATI
                     VPNFCDARLLNSMNVSSGVEFIRRKFLAGEIALISDEVLELSGFYEELSDDDIKN"
     gene            53724..58052
                     /locus_tag="KRO40_000542"
     CDS             53724..58052
                     /locus_tag="KRO40_000542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
                     /protein_id="HBH2091381.1"
                     /translation="MREIAKKEMYHIDVVIDVTGDEQTKNKLSAMERYTKQTEKRMRA
                     LNRIKANPVIQAQDKTSSVVNRISNNLKRVGRTISTTINAKDRASSVVNRVKNKVNSL
                     LTSRQREVLLKARDKASQVVDKVKAKVQNLTAATIISLNMKADPALRVISQTRSKLGE
                     LKNNTIINIKAKGEEALNTISRTKSKLQEFSNRTYQAIVKLKDEASPTLSGLDGKISS
                     FISSTISKFTQLAVTATALIGGVGVGSAIKGFADFEQAMKNAQAVSSANSKEMAEMTA
                     MAREMGRTTSFTAKDAGNAMYFMGMAGWKSKEMIAGLPGILNLAATGQTDLALTADIV
                     TDGLTALGLTAKDTGMFVDVMAATVTNSNTDIERMGETFKYMGSVGGALGVSMKDLSL
                     ATGLMASASVKGSMAGTALRGGLVRLIKPPAEAQKAMNKYGIEIKKTKDGNLDLASTI
                     VDLREKLGGLEGVQKSAAISSIFGRTAMAGWAAVVNASEKDFKKLTTAINESEGEAKR
                     IADMKLDTLSGQFEILKSAIDDVRISVGQRLGPMTRSFVEQLTKDMPKIGDAIVSFVS
                     DFINDFDKIKSIMQNVISVISGIVSAFIAFKALKFISFLIPILSDIGFAIAAFAGGAA
                     TLGEALLFALGGPVGAVIAGVVLLATAFTLAYQKSDAFRKIVKNVGKSIKNFLQEAII
                     AISPFVNVFGNKLKELGKAVIPLLKVFGDFASTLMSKIGPIILFLSSNVLAGFILTFV
                     AAVEAVKSAVVAITGVLQGLTSIIKGVFDIVGGIISGDGKQIINGLKSVFEGGIKIVS
                     SVWKGLVDIVTSPIQAVVDVLDEKFGKKVEGIKKKWNELKDFLKNPTKAAPKVQPVNL
                     SGEKASNELQASSNGAKAYISSLGQKIGEGIGKIKDKFGELKISATEVFNNIVSFVGG
                     KATELKDKLLEGIKPAIDTFKQSLSNLKEVFGDSLDSIKEAFGGLKTVFDENIKTPFE
                     NLKQKVLETKESLKPVFDNLKSSFAELGKALEPIKEAFSGIKDFFSNLFKPIKDDGAT
                     KTTKTNMDELKQSTQRVGTSFKELGNAFNQLKEAAKPFIDYLKQIKDSLTSTLGDIGG
                     GLLKGVATSIVLVITSVINAIASIINAVAGAIKGVIDIIKGIFEIIGGIISGDGEKIK
                     QGFSDVFKGIGEVVKSLWEGIKGVLGAPLKAVVNFIDNGFSEKVGQVKQWWSDLKTNV
                     GQKISGFVSFVSNGFQQKVQQVGMWWQGLKVNLSGKISGFVSLVENGFKSKVDSIKSA
                     WDSLRKKLSQKITGFVSIVKTGISNVLDRFADGGVASKPSICGEAGPEMVIPLSNSKR
                     SRALSLYEQAGQMLGTKASNNVIPISQKLGTSFNSASSIQNSNSSIINNVRQFPTKQE
                     EFNNTENRIYQEAQPQNIISSGSNAINVGGISINIQGSNNKEEMIQEILSQVESGLRE
                     ALEDIG"
     gene            58132..58926
                     /locus_tag="KRO40_000543"
     CDS             58132..58926
                     /locus_tag="KRO40_000543"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091382.1"
                     /translation="MWGRFKNMSIILKVLVLVCAIAIFPITLLAFSIEFVVKSFKRNE
                     RFKVVFGVFLVFITFSFVCIWYLLEDNITTSNSSNKKQEEHLKEEPGKNLATREAEEE
                     TNKKKEQEKQKNEGTEAEKKERDKTEKKEKVDKKYQEKNKEKAETKKQTLTSEELKKK
                     VDSIIPAEYKGNYYTNDVLDTDGSYVLSLQVQNASFDNESSCKAFTKDLINKLKEFRI
                     DSAEVYFVGSSGQTTYQINIDDFLKVQDNIKSVDNMEFFSFKDFKN"
     gene            58996..59667
                     /locus_tag="KRO40_000544"
     CDS             58996..59667
                     /locus_tag="KRO40_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HBH2091383.1"
                     /translation="MVIDIYLKNEKEKIDFHFPVNPFDSLSIKKEKRFETVDIVNLGE
                     FDIKKEGEKIREISFKTFLPNLYDASYCRYSELKNPIEVVAMLEKWVDQAEPLRLIVT
                     GFGYNGLVTISNFSNTQTAGREEDRDIEITFRTYRELKIETLKKETKSNTKTDLKDNR
                     PNNKTTPKIYTVKSSDTLYKIAKNLLGKGSRWPEIYNIPENKKVIGKNPNVIKKGQKL
                     VIPSK"
     gene            59664..60626
                     /locus_tag="KRO40_000545"
     CDS             59664..60626
                     /locus_tag="KRO40_000545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XkdQ"
                     /protein_id="HBH2091384.1"
                     /translation="MKIILNGKYDIANFNEGITLSEAIDGVAYKMDVSLVEPKQLQDI
                     WIKKGDKIVLIDIAYESKKEETIFDGVIWETRRSEKSKKLTLSCRERTVYMEESEEQY
                     SFKENTATQRIEYYCKQWNIPYYNLANTSVKLAKVIHKTNILDMIKKDLKETASKGGD
                     LFRVRMDNKLKLFKLGTNANVYKLDSILEDANFTSSFNDAVTSVKVLGKSKDENTKAP
                     IIGTYKKDSDKYGTLQKIKQDEKIKNTKEAKKAAEAMFNSGEETISVDCAVDINRIRA
                     GDKVSLKSKEYYVIDVTHTLDSRLKMKLNIGTLEYIRRKFYNND"
     gene            60619..60981
                     /locus_tag="KRO40_000546"
     CDS             60619..60981
                     /locus_tag="KRO40_000546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091385.1"
                     /translation="MTDARFNGIARILKENMNKSVANSTFGMGCELAEITTNGLKVNG
                     YKDEIQDYLVLESLILKEDYFTFSDEALSGEYRHKHKIETTKELKPLAIGDKVLVAVM
                     GAEFAVIGRVVNAKPISN"
     gene            60959..61417
                     /locus_tag="KRO40_000547"
     CDS             60959..61417
                     /locus_tag="KRO40_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH2091386.1"
                     /translation="MPNLFPINEKFETVELKNNDENELDLKGSFLFDFEKGEFVKNAD
                     GTLKKCDKVQAYKQWCQKAILTPRHKRSAYSSVYGSEIKELIASNLSQNAKELEITRL
                     IKETLLVHPYTKEVGEFSFNWLENSRLVEYEFNVLTIDDENIVIDGNIKR"
     gene            61426..62562
                     /locus_tag="KRO40_000548"
     CDS             61426..62562
                     /locus_tag="KRO40_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH2091387.1"
                     /translation="MQRELPIPVFLTEDEDSVHERMLSNFQDVSTLEGDFIYDATRPT
                     AEQIAELKQLGLQNNLKIAFPQTSYGTYLEWLGECKGVFKNQPTKATGVITFTGMQGT
                     IITKGTIVTTIATDEKQSIEFELLETKTIGENETVDIKAECRVAGIIGNVSKGSVAVL
                     LGSINGIKSVTNKEDFKGGTDIEDEEHFRERVLVAEQEDKLSGASSDYIRWAKEVDGV
                     GYAYVVPEWNGAGTVKVLILDKNRKAATQELIDKVQEYIYPLNISEGENRDGKAPIGA
                     LVTVVTPDTLLINVKASFIFSNGFSEETVLNNLKTKIDKYLDKIDLGGTVSYNAIQAI
                     VGSMMLTDEGIEDFSNLTINDVKENIKLQDQVVGIGEIVNEVVG"
     gene            62559..63188
                     /locus_tag="KRO40_000549"
     CDS             62559..63188
                     /locus_tag="KRO40_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmfQ family protein"
                     /protein_id="HBH2091388.1"
                     /translation="MIASKKGKEMLLTLSPIYEQSIIMQSLYEAIGSEFDNLELLNKE
                     IELQLFPQSATWGLEFWENRVGLSTNIDEDIEARRRKVIAKLQSKYIMTPKRMAMILQ
                     SYTGANIKINENISPYTFGVELTSTQGFPKDLEDLYKRVNVIKPSHLAVSYKLVSLLK
                     SKTYFAQTAIMSEEITVYPYTSKEVKASVKAKFALAHNMSSETLTVYPR"
     gene            63201..64223
                     /locus_tag="KRO40_000550"
     CDS             63201..64223
                     /locus_tag="KRO40_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH2091389.1"
                     /translation="MADEQFYTILTNIGKAKIANAGMLGKSVILEKIQAGDGGGNYYN
                     PTEDQTALKNKVWEGNINAFDNDENNPNWIIATACIPGSIGGFTVREMGLIDNEGDMI
                     AVCKSPETYKPKVDNGAMKDLYLKFIIEVSNVEKVTLVVDPTAIFLTKKDEEKILTNI
                     NKLDTKIDTTKTELTSNIETTKTELNTRIDTENEKQNIKIDQLIAGGSNVASTQIITI
                     DDWVEDAENGFKATVTHSLLTQRIVVNIIDATTKENAVTNFKIIDDNSIEVRSETRSE
                     LNVYVINGNAETHFINATVDDNRVSEMTTYSSKKIEDRFVNLEEKVNGGLSNIATSVN
                     ELITYC"
     gene            64240..65928
                     /locus_tag="KRO40_000551"
     CDS             64240..65928
                     /locus_tag="KRO40_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091390.1"
                     /translation="MQTEWNFGYNGSPQSVILKPGKYKFECWGSSGGINNSSWHTDAK
                     GGYSKGEITLKKQTTLYVYVGESGFASSSTSNNTKSGFNGGGKGYLNQQVMGTYYSMY
                     GGGATDIRLVGGAWDNEQGLLSRIIVAGGGGGSYSPYTGGAGGELAGGTGYSANDRHR
                     PGGTQYQGGIGRVSTENGSFGKGCSAKDSTGEGGGGGWFGGAGMNGVGAGGGGSGYIL
                     TKDSYKPTGYTPTSEYYFDNVVMESGGNTAGAYGYALITLLQALPFLTVSSYNSTTAT
                     FKADHTDPALLTKIEYFIDDVLKETITTDLTLEKTINYTLEDNALHTLKIVVTDSNNA
                     TAEKVLSISKNIMPLPENVNLNDISTKLTEVNAGFKTGKTSIINTLALKNIEASLNNT
                     LVELSEKIKTSFDSSDASVQDLMNQLTQSNNTITQLNTKYQYFSGVTTLIGNSICIAN
                     FYGKASGMYPGYWIRVGGFKSVPNIFIAECEYIYDGKFYKHLIFASCGVFTKDFTIRL
                     CFSREIDVNTFSVKGDIFNIEEQDVWYNTNLGLNLPAYNTNIPVNFNWCAIKFK"
     gene            65942..66235
                     /locus_tag="KRO40_000552"
     CDS             65942..66235
                     /locus_tag="KRO40_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091391.1"
                     /translation="MNRANRIIYDQTGKILLQTGEATGDILEHDEITELHCIDIEYGS
                     IDYTKNRITGINIETKEPILEEIPIFVSEEEKRIQELENQLLLNENEKVGGLL"
     gene            66235..66417
                     /locus_tag="KRO40_000553"
     CDS             66235..66417
                     /locus_tag="KRO40_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091392.1"
                     /translation="MNINNVVVRILAERILSRGLNPLKNREFELDDVTNTEYRKAVED
                     YIIKQSGVVEGIEPTA"
     gene            66451..67710
                     /locus_tag="KRO40_000554"
     CDS             66451..67710
                     /locus_tag="KRO40_000554"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091393.1"
                     /translation="MTFKELVNKVRNLVLEAEKVTIEDTENNFTSDNVEDALKEVFQS
                     GVDAKNNVVTALNSKGAEVTTSDTWEEIKNKINDSKCSFALFETTFTNKRFIINKIFD
                     EDVKEMTLFHNDIDCYFIVAKFYIYKMDSNFNLIYKNRLTYNPDGAYIDENYIYIGDV
                     YNLSKYDKESGNLVSSRTNIGCLYMCGDENYLYAVVTSGLGGVRPSEKFIKIDKLNLS
                     TIIENGDGTDNSTYEFRYHEKFVMNSNNIYFMKAKHKKNSYNDYYQYLCKMNPNTLNI
                     DTQLTIYNNVPYKDYVKGFVFIGDKIYLTKQRNIESALSKTLSVVDKDLNLTELGADT
                     YSPNRDLITDGTYLYSVSAWSSPSRFDLEKINVSDFKKITEYSCHSDLKSFVTLCNNK
                     ICFTSSSGICLAILVSNILIQKEGEEL"
     gene            67710..68009
                     /locus_tag="KRO40_000555"
     CDS             67710..68009
                     /locus_tag="KRO40_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091394.1"
                     /translation="MIYLGNLMDTEEQNIKYVGMIHYKPSILGEEDLKSGILVDELPV
                     QQYIENKEAKLFINIDTKEVFYRYTDIKSSMEDKVNSTEQTIADLTFQLMSNGVI"
     gene            68011..68148
                     /locus_tag="KRO40_000556"
     CDS             68011..68148
                     /locus_tag="KRO40_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XkdX family protein"
                     /protein_id="HBH2091395.1"
                     /translation="MNWYKIIADFYKNGNWTKEQVKTAVEKNKITASEYKEITGEDYI
                     V"
     gene            68180..68410
                     /locus_tag="KRO40_000557"
     CDS             68180..68410
                     /locus_tag="KRO40_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin XhlA family protein"
                     /protein_id="HBH2091396.1"
                     /translation="MNEELFEADLKRHETRINKHGEEIDELKIANIESKAELKALCEN
                     LNSLTSMLKWLIGTMITTLVGFFIFAVQRGIF"
     gene            68430..68687
                     /locus_tag="KRO40_000558"
     CDS             68430..68687
                     /locus_tag="KRO40_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HBH2091397.1"
                     /translation="MDNLISFIPEQLLILVAALSIIGKGCKKYKQLDNKYIPVVLLIL
                     GIGFSIWMLGLSPVAVLQGVICWGISIGINQTYKQLKEENK"
     gene            68687..69517
                     /locus_tag="KRO40_000559"
     CDS             68687..69517
                     /locus_tag="KRO40_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003415961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2091398.1"
                     /translation="MKICITVGHSILKSGACTSADGVVNEYQYNKSLAPVLADTFRKE
                     GHKADVIICPEKQFKTKNEEKSYKIPRVNSGGYDLLIELHLNASNGQGKGSEVLYYSN
                     KGLEYATRICDKLGTVFKNRGAKLDKSLYILNSSKPTAILIESFFCDNKEDYEKAKKL
                     GYEGMAKLIVEGVLNKSIESNEVKQMYKHTIVYSGDDRVSADILGLYYKREKESYLVT
                     DIKDYKPHRTQNLYVIGGVTCNKMKEMSKTTGEKFTQLYGNDVWSTLDKAIEFVKEKL
                     "
     gene            69844..70314
                     /locus_tag="KRO40_000560"
     CDS             69844..70314
                     /locus_tag="KRO40_000560"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091399.1"
                     /translation="MRKIEIFNKLTGISCPIFGVSWDPPESERKIARRIIVFLEPKRV
                     LYSPYEYETIEPVVNSVIEIKNYLTSELMNVNEKSELQGYIRAMRNSCNKFLSKCKDD
                     NNFRVQACCAGNISNWIFTSAIGEMRGNFGIMIGQIVSAYGISIEDDLANIIPE"
     gene            complement(70713..70901)
                     /locus_tag="KRO40_000561"
     CDS             complement(70713..70901)
                     /locus_tag="KRO40_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091400.1"
                     /translation="MTKTILCDYCNKGINKDDNKYITFHKKSHMKTNICINCALNLID
                     KDKLNENIINNQHGYSKK"
     gene            71157..71333
                     /locus_tag="KRO40_000562"
     CDS             71157..71333
                     /locus_tag="KRO40_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091401.1"
                     /translation="MKTLMFILVIAYYITIVIKSITTIVKSITRLLDSISRLKESLHK
                     LRNRPDGNQDDFNE"
BASE COUNT        28562 a         7749 c        12820 g        22406 t
ORIGIN      
        1 tataataaag aagctattta ataaagctta attactttta tgaacttaat ggattgatat
       61 ggtctatgat agcaatagaa attataacat ttttaataaa cttagtttta tataccttat
      121 agtataaatc taaaaaagca tcatctaaaa aggagctgtc acatgagcaa attaaatttg
      181 ttctatgata gctctttttt tacttatttt aattaggtat atttttaatt attttatata
      241 aagcttatgt tctaagtaaa attatgcata acaaacaaag gtataaaaat accatttttt
      301 cagataatat ttaattataa ataataaatt tagaatactt cttttaaatg atgagagtct
      361 agaaattttt atgtgtattc tttaaataaa aatttccaga ctctagcccc tttttgaata
      421 ttttaaaatt taacttaaac taagcaaatt ctataatagc ttatctctaa atatttaaat
      481 ttaatttaca aaaacaatat aaatatcata ataaaataaa attttttaat attactaaaa
      541 atatatagac aaaataataa caaatatagt attatgtaat tgtagaaatg cttttcatag
      601 gtatattcta tgaagatgaa ttgcataaaa atgaaaaaat ggaatggata ttatttaggg
      661 gtgaaaaatc atgaatccat tagttataaa cttacaaaaa tgtagcatac atgatggacc
      721 agggataaga agtacagtat tttttaaagg gtgtccactt gaatgtgttt ggtgtcataa
      781 tccagagagt caaacatata caaaacaagt tttgtataat gaagaaagat gttcaaaatg
      841 tgaagcatgt ataaatatat gccctcataa ggcaatttac aaaggtgaaa caaaaatatg
      901 cttagaccaa gataagtgtg agttttgtga aacttgctta gactattgtg taaacaatgc
      961 aagagagatt gttggtcaag agtattctgt aagagatttg gttaaagaga tagagaagga
     1021 tagaattttc tatgaagaat caggtggtgg agtaactcta tcaggtggag aagtaatggc
     1081 tcaagatatg gacttcattt gtggagtaat aaacatgtgc aaatcaaagg gaatccatgt
     1141 agcaattgat acatgtggct atgcaaagtc agaaaattat gaaagagttg ctaaatgtgc
     1201 agatttgttt ttatatgata ttaagcttat tgatgaagat aagcacataa aatttacagg
     1261 aaaatcaaat gacttaatac tgaaaaatgt taagatttta agtgaattag gggctaacat
     1321 aaatataaga ataccattaa ttgtaggagt aaatgtagat gatgaaaatt tagaggttaa
     1381 aaaaatgata gagtttttaa agcctttgaa tatacaagca gtaagtcttc ttccatatca
     1441 taatattggt aaacacaagt atgataaaat ttataaaaag tatgaaggag aagaactaca
     1501 aagaccatca gaagaaaaat tagaggaaat aaaaagactg tttgaagcaa gtaatttcaa
     1561 tactaagatt ggagggtaat aaaatggcaa gaggaacttt tgagagaact aaaaaattaa
     1621 gagaagaaag tattaatgca gaaccacaca tatctattga aagagcagta cttatgacag
     1681 aagcttataa aaaatatgag ggaagtgtag agattcctgt acttcgtgct ttatcattta
     1741 agcattatat tgagaataga actcttagca taaatgatgg agaattaata gtaggtgaaa
     1801 aaggtgattc tcctaatgga gcaccaacat atccagaaat ttgttgtcat acaatggaag
     1861 atttagaagt aatgcacaat agagatataa taaattttag cgtatcagaa gaagctagaa
     1921 aaatacataa agaagaaata attccttttt ggaaaaagag acaaacaaga gataagataa
     1981 taaatgcaat gacacctgag tggttagcag catatgaagc aggtatgttt acagagttta
     2041 tggaacaaag agccccagga catacagttt gtggagatac aatatataaa aaaggatttt
     2101 tagatttaaa gaaagacata gaagcaagat taaaagagct agattttctt aatgatttag
     2161 atgcatataa taaaaaagca gatttagaag ctatggcaat agcttgtgat gcaatggtta
     2221 tattaggtaa aagatatgct gagaaagcaa gacaaatggc agaagaagaa acagatgaag
     2281 ctaagaaaaa agatttatta ctaattgctg aaacttgtga tgttgtacca gctcacaaac
     2341 cagaaactta tcatcaagct atacaaatgt attggtttgt tcatataggg gttactactg
     2401 aacttaatat atgggatgct tttactccag gaagacttga ccaacatcta aatcctttct
     2461 atgaaagaga tgtagaaaat ggaatactag atagagatag agcacaagaa ttacttgaat
     2521 gtttatgggt taaatttaac aatcagccag caccaccaaa agttggtata acattaaaag
     2581 aaagtagcac atatacagat tttgcaaata taaacactgg tggaataaat ccagatggtc
     2641 aagatggtgt taatgaagtt agttatataa tacttgatgt tatggatgaa atgaaattga
     2701 tacaacctag ttcaaatgtt caaataagta aaaagactcc tcaaaaattc ttaaagagag
     2761 cttgtgaaat atcaagaaaa ggatggggtc aaccagcatt ttataatact gaagcaatag
     2821 ttcaagagct tatggaagct ggaaaaacta tagaagatgc aagacttggt ggaaccagtg
     2881 gttgtgttga aactggatgt tttggtaaag aagcatatgt tctaactgga tatatgaaca
     2941 ttccaaaaat acttgaatta acattaaata atggatatga cccaattagt aaaaaacaaa
     3001 taggtattga aactggagac cctagaaatt tccaatctta tgaggaacta tttgaagcat
     3061 ttaaaaagca attacattat atgattgaca taaaaataga aggaaatgct gtgatagaaa
     3121 atatatgtgc aaaacacatg ccttgtccac ttatgtctac aatagttgat gattgtatag
     3181 aaaaaggcaa ggattaccaa agaggtggag caagatacaa cactagatat atacaaggtg
     3241 ttggtatagg aactataaca gatagtttaa cagcaataaa atataatgta tttgataaga
     3301 aaaaattcga tatggataca ttgcttaaag cacttgatgc taattttgaa ggatatgaag
     3361 ctatacttaa tttagtttca aataagactc ctaaatatgg aaatgatgat gattatgctg
     3421 atgaaataat gcaagagata ttcaatgcat attacaatga ggtaactggt agaccaactg
     3481 tttgtggtgg agaatacaga gtagatatgt taccaacaac ttgtcatata tactttggag
     3541 aaattatggg agcaagtcca aatggtagac tttgtgcaaa accagtttca gagggaattt
     3601 cacctgaaaa aggtggagat actaatggac ctacagcagt tataaaatct tgtgctaaga
     3661 tggaccacat aaaaactggt ggaacattat taaatcaaag atttgcacca tcagtagttc
     3721 aaggagaaaa agggttagat aatatggcta atctagtaag agcatacttt aatatggatg
     3781 gtcatcatat acaatttaat gtatttgata aaaatgtact gttagaggct caaaagaatc
     3841 ctcaggatta taaagactta atagttagag ttgcaggata tagtgaccat ttcaataatt
     3901 taagtagaac actacaagat gagataatag gaagaactga gcaaacattc taggtttgct
     3961 tgtaaataaa acttcttact atataaaatc gtaactgata taataaagta taaatggttt
     4021 gattccattt ttaaaatttt agattaatta tgagctaact ttctaaatag gaagttagct
     4081 cgttaagttt aatgaaaaaa tcgttaaatt tatatttagt aaatcataca catattagta
     4141 agtaatacat acaaaagaat aatttattat agttataata aggttatatt ttataaaaat
     4201 aagataattt taagcagtta aaataaagtc aatttagcta ctttaaaata aaactaatag
     4261 aaaaaaggag atttgatatg aaaactttag gatttattgg ttcagggaat atgggaagtg
     4321 caatgatagg tggcatagta cagtcagaat tagtaaaggc agaagatata actgtatcag
     4381 atttaagcca agttgcctta gataaagtaa aagaagaatt tggagtaaat actacaactg
     4441 attcaaaggt agctgttaca aattctgatg tggtaatagt agcacttaaa cctaatatat
     4501 gcgaaaaggc tttaactcca cttaaagaat taatagatgc aaataaaata atagtatcta
     4561 tagcagcagg taaaactata gaaagtctgg aaagttttat aggttcagat aaaaaaatag
     4621 taagagtaat gcctaatact ccagcccttg ttggcgaagg aatgtcagct ctttgtaaaa
     4681 atagtaatgt aacagatgaa gagttaaata tgattaaggc tctgtttgaa tcttttggtg
     4741 aggcagaaat agtatcagaa tatttaatgg atacagttac aggtattagt ggttcttctc
     4801 ctgcatatgt atttatgttt atagaagcta tggcagatgc agcagtatta gctggaatgc
     4861 caagacaaca agcttataaa tttgcatctc aagcagtaat ggggtcagct aagatggttc
     4921 ttgaaactgg aaaacatcca ggtgaattaa aagatatggt ttgttctcca gcaggaacta
     4981 ctatagaagc tgttaaggta ttagaagaag aaggctttag agcagcagtt ataaaatcta
     5041 ttgttgcttg tatagataag tctaaagata tgagcaaata acagatgtaa ttaagtttac
     5101 tatatggttt cttgaattgt ttttttagtg cttatttata tctatacata aatgtatttg
     5161 gtataagtaa aataagagta atttactata aaaaggaatt taatgattga gtgagaattt
     5221 attacttaaa tattaataat taaatagata tatttttaac tatatttgag atatgtcatt
     5281 gtgaaaaaat aaaatttata agtattattg tgaggttata agtagattta tttaaaaata
     5341 aatttattta tagccttttt aaatttgaaa taatattcat aaggtaataa aagttacaaa
     5401 tattttcttc gctaataagt tttaaaatac ctataatgtt ttacttttta ttataataaa
     5461 tacaataaat atattcttat ataaattcta tgtcagatat atggaaagat aagaaccttg
     5521 agattatgtt aaaaaatcta gattttatac ttataaaaag tttgatttta caaccttaca
     5581 aaagagaatc aagataggaa tataattatc tttttcataa atatataaat gatatactaa
     5641 tattatagta ttattgatat ttgtattgga ggttgaacat gagggatgaa attttaagtt
     5701 ttgtaaatga atgtgtatta tttaacaact ttgatgaact taaaaaagaa agtggcataa
     5761 taacagaaga tatagtaaaa aagtttaatt taagtagaac tcaatcaagt agattattaa
     5821 atgatttagt aaaatctgat aatcttataa agataaacag tagacctgtt atttttttac
     5881 ctaaaaataa aataaatgat gtagtaggac ctacaaaaaa aagtatttat gaaaatttag
     5941 atgaacttaa aaatgagtgt aaattattaa agcaagagac tgtgtttaat agtatcatag
     6001 gatatgagaa tagcttaaaa gaagtaatcg aacaaataaa aaccgctgta ctttatccaa
     6061 atggcggact tacaataatg ctgacaggtg aaagtggagt aggaaaaact tttttagcca
     6121 agataatata caaatatagt gtaagcagta atgtattaga aaaaaattct ccatacaatg
     6181 tgttaaactg tgcgcagtat tataataatt tggagttatt gtctagtcta ttatttgggc
     6241 atgtaaaagg agcatatact ggagcaaatg aatctagagc aggtctaata gaacaatcag
     6301 atggtggtgt tttattttta gatgaagtac atagattaaa tagtgaaggt caggaaaagt
     6361 tatttacatt tatggataca ggtacgtttt ctaggattgg agagaatgga gtaattagaa
     6421 aagctagggt aagattaata tttgctacaa cagaaagtct atctgaattt ttacaaacct
     6481 ttttaagaag aatacccata aatatttatg ttcccaatat agaagaaaga gggactattg
     6541 aaaaaagaaa gattgtagaa cattttattt atgaagaaag taaggtactt ggtttgccta
     6601 tagagataac tcaaattaca ttaaatgcga ttttaaagat aaaattcaag gggaatatag
     6661 gtgaatgtaa aaatgtaata aaatatgcat gtggacgagc ttatgcaaaa aatcaaagaa
     6721 gaaatggaaa tatttttgtt actcttcaag accttcctag aaatctttat atagaaaatg
     6781 tagatatatt tcaattccaa agtggtaaaa gcaaaagcat tatcttttct cctaaacaat
     6841 ttagtattga aatgtcaaat ggaagaaata aaagaaatat aatctatcaa agtttcataa
     6901 aatgtttaga ttactttgat agactagaaa aaaatgaaat aacaaaggaa aaatttagta
     6961 aaaagagttc taatctaatg attagactaa tggacaattt agtcttttca aataatgatg
     7021 aaaataataa cgtacttatg gagcttataa tatcgataat gcaggatata tttagaaatt
     7081 tagaagttaa taacaatata aaatatgatg ggaataatgt attggcattt tcgtcttatc
     7141 tttatttgaa ggacgaatct tatcaattgt ctgatgagta taaagcttta gaaaataaat
     7201 tactaatata tttaaaaaaa gagagttaca aagaatactc tataataagt aaaatatcaa
     7261 cattaataac gaatagattg gatatgtatc ttaataatgt agatacaatc ataatgatta
     7321 tatttattaa atcaacaatt ataagaatga aatttaatca agttaatgcg actattatag
     7381 cacatggata tgctactgcc agtagtatgg cgaatgtatg taatcggatg ttgggtaaaa
     7441 atatatttac agctattgat atgcctatag atgctactat tgctgatgta tcaaaacaaa
     7501 tgtctagata cctagaggga gataggataa agaatggttt aattgtgtta tttgatatgg
     7561 gctctcttaa tcttatattt gaagatttaa agaataagat aaatagccca atgttattta
     7621 tagaccaaat atccactatt tctgcactag aagtaggaaa tttattaatg caaggtaaaa
     7681 acattgaaga gattgcagaa attatggatg aagaaactaa acctaatata caattgtatt
     7741 atcctcaaaa aaataaagaa tatgctataa tatcatcttg ttttacaggg ataggtactg
     7801 ctataaaaat ccaacatcta ctttccgaaa gtttaattgg aatagttgat gtcaaaataa
     7861 taccttatga ttatgatagt cttgtttcta tgggagataa agaaccagtt tttgaaatgt
     7921 atgatgtgat ggctatagta ggaactgcca atccaaatgt gaatggggta gattttatat
     7981 tattagagga tataatatca ggaaaaggag aagatgatgt ttttagaata tttagcagag
     8041 tagtagaaaa tgaaaaaata aagaacataa atgattctat tgtaaagaat ttttcattaa
     8101 ttagagtaat agatagtcta actattttag attcaaaaaa gataatagag agaatagaag
     8161 aaggaattaa tgctatagaa aatattcaaa agaaaaaact ttcaaatgat aaaaagattt
     8221 ctttatatgt tcacttaagt tgtatgattg aaagattagt tagacaaact gaaattgaag
     8281 agtatactga tatggatttg ttaatcaaaa accatcatag tgaagtaaaa ctaataaaaa
     8341 atgcatttag tgtgctagaa aagagttata gtgtgcaaat accaatttca gagataggat
     8401 atatttataa tattatctat ggtctaccac agtaaaatac aagattacaa aataagtgaa
     8461 tgaaatttaa aaaagtatgc cagtatttgg catacttttt gcttttatag ataaatgaga
     8521 gtataaacaa taaaaatttt aatgtatgat ggaggatttg gggaaaatgg tatctttgat
     8581 gagaattgat gacagattga tacatggtca ggttgcatat ggatgggcaa catcactagg
     8641 tataaatgta atactagttg caaatgatga agcaaaaaat gaccaaatga aagctatgtc
     8701 actgaactta gcgaaaccta gcaatgtaac tttatatata aggggggtag aggaatctgg
     8761 agaaatagta gaaaaatttg cttcttcaaa gaaaagcaat gtattagtgt tagtaaaaaa
     8821 taccaaagat gctttagttg tagctaaaaa ttcaggagga gtattaaaag aaataaatgt
     8881 aggaggatta agatatgagg aagggaagaa gaaacttaca gatttagttg ctgttgatga
     8941 tgatgatata aataacttta aacaaatagg tgatttaggg attgatatag aatttagaat
     9001 gttacctaga gacaaaaaga aacaactatc agatttaata aaataattta ggagaaagag
     9061 aatgaaaaaa tttctaattg caacacatgg agaattgtcc agagagcttg ttgacacaag
     9121 taaattaata attggttcat taactaatat tgagtatttt tgtatgacaa cggataaatc
     9181 agcagatgat gctgagaaag aaattagaag tatattatca aataataaag atagtgaaga
     9241 atttgttgtc ttaacagatg tttttggtgg aagtgtggca aacatatgta caaacttact
     9301 tttacaaggg ttcaaatttg aattattgac aggagtaaat ttaccaatgc ttttatctat
     9361 acttttatta gttgaggagg atacaaaact aatagttaaa tcaggattag aggaagcaaa
     9421 aaatggaatt gtttatgtaa atgagttatt agaaaatcaa aacaaaatca aaaatgtaat
     9481 gtaatttaat gtaaattaaa ctaagttaaa atggaggttc aatatgttag tacaagctac
     9541 tatgttagct attatagcag gagttggtat actagatggg cgtatatttg gtcaatctat
     9601 gcttgatagg ccaatagtta caggtatgtt agtaggatta gttttaggag acataaaatc
     9661 aggaattatg attggtgcac agcttgaatt aatttggatg ggaattgcag gaataggtgc
     9721 agctactcct ccagatgtag taacaggagg cgtattaggt acagcttttg ctatattatc
     9781 aggtaatggt gcagaagttg ctttagcagt agcagtacca gtagcagtct tagcacaatc
     9841 tcttggagta ttagttagaa taataaattc gtacttttct caaaaggcag ttttctatgc
     9901 taaacaagct gattttaaga aagttaccat aatgatgtgg ttgccagtaa tattattctt
     9961 tttaagtaca tcagttccaa cctttttagc aattatgatt ggtgctgata aagttacagc
    10021 attgataaat gcaataccta aagttatatt agacggactg ggtgttgcag gaacattgtt
    10081 gccagcagta ggttttgcat tgcttatgga tatgttactt tcaaaaaaga tgtctgtatt
    10141 tttctttata gggtttttgt tagcatctta tggtggatta gatataactg ctatagcttt
    10201 atttggagta tgtgtagcat ttgtactaaa cttttatatc aataacaaag aaaataatca
    10261 aaatcctcaa ttagcaatca atactttaac ggaaggagag attgactttg aataaattaa
    10321 caaaaaaaga attaagaagt atgttttggc gttcatttgt tcttcaaggt gcatttaatt
    10381 acgaaagaat gcaaaactta ggttactgtt attcaatgtt acctgcaata aagaagctat
    10441 acaataagaa agaaaatcaa gcaaaagcaa tagaaaggca tttggagatt tttaatacaa
    10501 cgacagtagt agttcctgct atattaggta taacagcagc tatggaagaa gagaatgcta
    10561 ataatccaga atttgatgaa agttcaatta gtgctgttaa aacagctctt atgggacctc
    10621 ttgcaggaat tggtgattca ttattctggg gaacatttag gattatagca gcaggagtag
    10681 gagtatcact tgcaaaagaa ggtaatatct ttggaccact attattctta ctattataca
    10741 atataccagc atttgccctt agaatatttg gacttaagta tggttatcaa gtaggggtaa
    10801 attctcttga aagaatacaa agagagggac ttatggagaa aataatgtct atggctacaa
    10861 ctgttggttt attcgttgta ggaggaatgg ttgcaactat gttgagtata actactcctc
    10921 tgaaattcaa cttaaatggt gcagaagtaa ttttacaaga tatactagat aaaataatac
    10981 ctaatatgtt acctttaacc tttgcatttg taatatacta catgttaaag agaaaggtaa
    11041 gtgtaacaaa attaactata ggcactatag taacaggaat cgctttacat gctataggtt
    11101 tgttatagaa attaattata atttattgaa tatatagata aggaaggtgt ataaaatgac
    11161 aatacaagat tatatgttag aaacaccagt tagaatgaga gaaattatat ctaatgcaga
    11221 tagcttattt aatgaagtta agagaacaaa tctaaaaaag attataataa caggttcagg
    11281 tactagctat cactcaggag tgcaagtgca accatattta caaaatttat tagatataga
    11341 tgttgtgaaa atgtatccat ttatgataac tgaagataca ttcaagtttg ataatgaaaa
    11401 taccctagta gtaggtgtat ctcaaggtgg gagtagttat tctacataca acgctatgaa
    11461 gttagctgaa gataagggct gtaaaatagc atctatggca ggttgtaaga atgctttaat
    11521 agatgagatt tctgattata tattaacagt aaattgtggt gaagaaaaat ctggagctaa
    11581 aacaaaagga tattattgta caaagttaaa cttaatgtta ttaggtcttc aaatagctag
    11641 agaaaaaggt ataatatcta gtgaaaagta caatgaggaa ataaataaga tattagacgc
    11701 aattaataga tttgaagcag tgtataagct ctctaaacaa tggattgaaa gaaacaaaga
    11761 aaagttagtt aattctaaag aaataagaat aataggtcac tctgatatat atggagatac
    11821 attagaagca gcattaaaat tattggaaac aatgagaata cctgtaactg ggtatgagtt
    11881 tgaagagttt atacatggta tatataatgc tataaatagt gattctacta tatttatact
    11941 agatacagga aaagaaccta gagtaactaa gatgattgat gtactttctg gttggacgga
    12001 aaatgtattt gctataggta gagatgttac agaaaatgat aaaaatttaa agattgatat
    12061 cacagataat ccttactatc aaacatttaa ttttatagta cctatacaac taatatgtgg
    12121 ggaaatacct acattaagag gtgtagaccc aagtgttcca aaagatacta ggttccacat
    12181 gaagttaggt agcaagaaac tgaataagta acaaaaaaag aggttgtctc aaaatagaga
    12241 taagcctctt ttttactaga taagctcttt tttactgttg aaatgatgaa aatatatttg
    12301 attttctata aaaaagagtg cctcatgaac taaaaagtta attttgagac acccactttt
    12361 atcttatttt aaactaaaat atttatatat tagtgtgcat tatttttttt attgctgtct
    12421 tccttacttg agcaagaatt agcacttgga catccagaac aaatagaaca tccactacag
    12481 acatttccgt tttttgtaga cttgaattta ttaaacagaa taaagagtgc aaggactata
    12541 attattccac ctatcaaagc ttctattatt gaattaccca taaatagtac tccacctata
    12601 cttttaacta taaaagccat tatccatgct agtataaatt gatatgcaaa tgatgtaaac
    12661 atcattttat tgccatattc ttttttcata gttgcaagtg cagctataca tggagtatat
    12721 aaagcagtaa atatcaagaa tgtatatgca gtaactccat taaatattgt tggtaagaca
    12781 acagttagat taccatatag tatatttaaa gagtttacta cgatttcttt tgctccaaga
    12841 ccacttaaaa tagcaactga agttctccaa tcatcaaaac caagaggttt gaatatagga
    12901 gatataatat gacctagagt agccaagaag cttacattta tatcttctgt atatccaaaa
    12961 acattgaatg aagaaagtcc ccaaattacg actgacattg caaacatgac agtaacaact
    13021 cttatcaaga aaccttttga tttattccaa gtatttttaa taagtgcatc tatagtaggg
    13081 attctatatt ctggtaattc taatataaat ggttcagcct ctgttttaaa ggctgtttta
    13141 tttaagaata atgcaactac aattgccata actataccca ccaaatacag tgatgtagtt
    13201 actaaagcag cattatgtgg aaagaatata gctacaaata gtgcatatat aggtagcttt
    13261 gctccacaag tcataagtgg tgcaataaga gctgtaactc ttctatcttt ttcgctttcc
    13321 aatgttctag ttgccattat agctggagaa gaacatccca tacccataac tataggtata
    13381 aaagctttac cagatagacc aacctttctc ataactttat ccattaaaaa tgctgttctt
    13441 gacatatatc cactatcttc aaacaacgat ataccaaaga ataatgtaaa tattaaaggg
    13501 aagaatggta aagtaccacc aacacctcca attattccat caactataag tgatttaaac
    13561 catgggctag agttagataa catatcacta acaggtgcag aaatataagc ctctataaga
    13621 ctagcaaatc cctcttgtag tggacctccg acccagtcaa aggtaaattt aaataagagg
    13681 aacaatacac caataaatat tggatatgct aatataggat tcaagactat attgtctatc
    13741 ttatcactga tagatttctt ttgtgtatat gtagtttttg tacatcttga taaaatggat
    13801 tctaattttt tatatgtttc tgtttcactt ccaaagtttt tctgatatat aaaagctttt
    13861 tgcgtagctc ccttaatctc ttcttctatc ctatcaacac catttttctt ttttgctata
    13921 attggaacaa caattactcc aagttcttca cttaattttt tggcatctat attaactcct
    13981 ttagattctg caatgtctaa catattcagc aatataacta taggcttgtt aaattgcata
    14041 agttgagttg ttaagtaaag gtttcttgat aaattagaag catcaactac atttactatt
    14101 acatcaacat cttcattttc taaatatgat ttagaaacct tttcttcatt tgagaaagta
    14161 tccattgcat atataccagg taaatcgaca acctttatct cttttccaag aaatccttct
    14221 tttttttcta tagtaacacc aggccagtta cctacatatt gatttgaacc tgtaagtaga
    14281 ttaaaaacag tagttttacc gacatttggg tttcctaata atgctacatt aatcacgggt
    14341 agctcctcct ctattattgt aaagaaatat ttttagcatc agattttcta atcgcaaggt
    14401 caaagcctct aaatctaatt ataattgggt ctccaagtgg ggcaaccttt ttaacttcta
    14461 tttcagtact atttatacat ccaagtgcaa gcaatctttt agataattta atatctccat
    14521 ctatactatt aataaatcct ttttctccta tttttaaatc gtaaacagtc attattaaca
    14581 cctcctaatg aaattcatta tcattaaaat tgtaacaagt atgatacaaa aagtcaagat
    14641 ttatagaggt aattgcacat tgaaataact aatatttatt ctaaatagat taaaaatatt
    14701 ttagtctaaa ttaggtgttt ttatatattt tgtattataa tgtaagatga tagataaaat
    14761 ttggaggagt taacttaatg aaaactagaa aaatgacatt tttaggtctt atgatagggt
    14821 atagtttagc tttatatgta ttagagacat atataccaaa tcctcttata gttatatttc
    14881 caggggcaaa attgggtttg agcaatatta taactttaat ttcattaatg ttgttaggtg
    14941 tcaaagatac tgttataatt gttactatca gggtaatttt gtcatcaata tttgcaggcc
    15001 ctttatcata tctactattt agtataggag gagcttatct aagtctttta tttatgtatt
    15061 tagcgagtaa aataaaagat ttatcactaa tagggataag cattataggt gcaatagggc
    15121 ataatatagg tcaattaata gttgcaagtt taatcattga aaatatactt gctatagggt
    15181 acttaccatt tatgttaatg gcatcattag taactggtat gtttgtaggc ttagtatcca
    15241 ggtatacaat acctaaatta aagcattttt atagtaagtt ttattgacat aatattgaca
    15301 aaatataata ttgtttgata aaatgtatat aaaaatatac aaatttgtaa tagtggtgat
    15361 tattatggcg aacaatgaat tagaagcgtt aaaaaatgag attgaagcag ttagggaaga
    15421 gataaataca tacatagaat atccagaaat atttcaagaa gagttagtag aatcaagtaa
    15481 gaaaatagat atattaataa ataaatacat gtacctaagc aaatagccca cagttgtggg
    15541 tttttttgta tcaaaaatta acagatggct atattttaca tatattaata ataatattaa
    15601 gatataaaat agtatttctg atgtgtaaat tatctggagg acataagttg taattaagtc
    15661 aggagggttt tatattatga ttgatatagg aagtaaggag atagcaataa ggttactatt
    15721 agcactaata ataggaggaa taataggctt agagagagaa aaaataagac agtttgcagg
    15781 atttaggaca catatactaa ttgcaatagg ttcttgtatt gtttcaataa cttcgattca
    15841 attattcttt gattataatt tgtatacaaa tgctgaccca gcaagaatgc ctgctcaagt
    15901 attatctgga attggttttt taggtgcagg agcaatttta aaaaataaag gtggagtaaa
    15961 agggcttact acagctgctg ggatgtgggc aactgcatgt attggtatag cagttggata
    16021 tggttattat gaattggcaa ttctaggtgg attatttgta atgatagcat tatttgtgct
    16081 taggataatc aatacgtttt tatttagcca agaaaagaat gtattgatat taaaattaag
    16141 caatttggat tctatacctt ttttatatga taaatttgaa aaaaatcaac ttatcgtaag
    16201 aaatatggaa atagaatgtc gtaatgaaga atactggaag gttaattttt ttgtatctta
    16261 tgctaagaga atacacttac acgacgttat gaaagaaata aatatgatag aaggagtaat
    16321 aaatgtagat tatttggact aaaatatata caatatattt tgtaaagtga ataaaatata
    16381 aaacaaatta aaatagaggt gtatgatatg ggaactgata gaagtacaat agaagaaaag
    16441 tacaaatgga agatagataa gatgtactcc agtaaagagg aaattgaaaa agacataagt
    16501 aaagtaaaaa atcttatcca agaagtaaaa gaatataaag ggaagctttc tgagagtaag
    16561 gagaacttat ataaagtatt aaatatctct gaaaatgcat ctaggattgt tcaaaattta
    16621 tatgtatata ctcatatgaa acaacatgaa gatactagaa ttaatgataa tcaaggaaga
    16681 gccactaaga cagaaatgtt atctactgat ttaggtgtgg ctacttctta tatagttcca
    16741 gaaatactgg cgatagaaga gaataagtta agtgaatact taaaagatga gaagctatcc
    16801 ttttatacaa aatatataaa ggatatattg agagataaac cacatacttt gagtgaacga
    16861 gaggaagaaa tacttgcagc tacatcagaa ttatcgacaa ttccagaaaa tgtatacgat
    16921 atgttagcat atgcagatat ggaatttcct gagatagaag atgaggaggg gaataaggtt
    16981 aagctttctc attcaaacta ctctttattt ataaaaagta agaatagtag agttagaaaa
    17041 gacgcttttg aaggtgaatt ttcaacatat gagaaatata aaaatacatt tgcctcaacg
    17101 ctttatggtg gaataaaatc agagatattt tacgcaaaaa ctagaaagta taattcagca
    17161 atagaagcgt ctttattttc agatgatgta agtttagatg tttacaataa tcttatatca
    17221 gctatagata aaagtattcc taatctaaat aaatatgttg agcttaaaaa gaaattttta
    17281 ggattgaatg aaatacacat gtatgatttg tatgttcctt tgacagataa atttgacatg
    17341 gatataccat atgataaagc acaggatatc atattagagg cacttaaacc tttaggagaa
    17401 gaatacttga aggtcataaa aagtgctttt gatgaagggt ggattgatgt atatgataat
    17461 gaaggtaaaa aaggaggagc ttattcttgg ggaagttatg attcacatcc ttatatatta
    17521 atgagctata aaaatgacct taattctcta ttcactttaa ttcatgaatt agggcactct
    17581 gttcacagcc attattcaag aacaagtcaa ccatttttat attcggacta taagatattc
    17641 gttgcagaag ttgcatctac attaaatgaa ttacttctta taaattattt attagaaaat
    17701 tctaagtcta aggatgaaac tatatactta ttaaattatt atttagaaca atttagaact
    17761 acagttcata gacaaactat gtttgctgaa tttgaaaaaa ttgtacatca aagggtagag
    17821 agtggagaac cacttactgc tgatgaattt actaatatat actacaaatt aaatgaaaag
    17881 tattacggaa aatctgcaat agtagataaa caaataggaa tagaatgggc gagaatacct
    17941 catttttatt caaacttcta tgtatataag tatgccacag ggttttctgc tgcaagtgct
    18001 ttaagtcaac agatactttc agaaggaagt actgcagtag atagatatat aaacttctta
    18061 aaaagtggag ggtcagaata cccactagaa caattaaaat ctgctggtgt agatatgacg
    18121 aaaaaagaat ctatagagga agccttaaat gtatttgctg aattagttaa taaactagaa
    18181 aaagaattat aggatgtgat aggttgatag cttcaatgaa gacttctaat aatatgagtt
    18241 gtattatgtt tatatctgcc taaagtaact ttaaaaagtt aatctaatta agaataaatc
    18301 atataaaatt aagtttttac atgtatttaa caatatttac atttacttaa ccctgctcta
    18361 atattcattt aacaaagaat ctgtattatt aaaatataga aaaatgacaa caaaaaatta
    18421 aaatataagc gggggtaagt aaaatgttta aaaagaaaat aggcgttctt ttagctagta
    18481 caatgttagt tggagcttta gcagtaggat gtagttctaa ctcaggaggt tcaggtgatt
    18541 caggagattc aagcaaagtt tctgtttcag gttcaacttc aataggtcct cttatggaaa
    18601 ctatcggaga aaagtttcaa gaaaaaaatc aaggtgttag tgtagaagta caacagattg
    18661 gttcttctgg aggtataaaa aatgctatag aaggaacatc tgaaatagga atgagttcaa
    18721 gagatttaaa agatgaagaa aaaagtgctg gattaaagga aactaaaata gcaatagatg
    18781 gtatagcatt gataactaat actgcaaact cagtaaaaaa tctgacaatg gaccaagtta
    18841 aaggtatata tacaggaaag attactaact ggaaagaagt aggaggaaat gatgcaccaa
    18901 tagtaatagt atcaagagaa gaaggttcag gaactagaga tggattccaa gaaattgtag
    18961 ggtttgattc agaagaacta actaaagatg cacaaataag tgatggttca ggaaatataa
    19021 aaactacagt tgaaggaaat gaaaatgcta taggatatat atcatttgga tatgttgatg
    19081 agaaagtaaa tagtttaaaa ataaatgatg ttgaagcaac tgatgcaaat gtaatagcta
    19141 ataaatatcc aatatcaaga ccatttatat tagttaataa agaagatggt ttgtcagaaa
    19201 aaggtaaagc tttaatagat tatatattaa gtgatgaagg acaagcactt gtttcagaaa
    19261 aaggatttat taaagttaat caataacaag agttataata taaagtaaac atataatacc
    19321 ctgtgagata agctcataaa aatgatgctt taacttgcag ggtattgtct attattgaat
    19381 gtagaaatat aaatatcttt agataaaata ggtattttag tatcttatat ctaagaatat
    19441 ggaaatattg acaaaataat attacaatgt tagaataaaa aagaaattta tgaaaatata
    19501 taaaagattt ttaataaaaa tattttagaa actgagaagt atatcttatt attgggcatc
    19561 tggagatata tggagttagt ggtgcaaccg gctatgaata taatttttat attgcatagt
    19621 ctttttttgt tttaaaatta acaaaaatgt tgcaaaattt gaaaataaga gtattagtcg
    19681 ttaagatttt tattgatagg taaaattttg gcttttaaag tagccatttg ttggaaaagg
    19741 gaaatttttt taaaagaata atagtattat aataagaaaa taaagttttt ataaacattg
    19801 agatgcagaa tataaacctt ttgtaacaat atatttacca aaataataca atttatttta
    19861 tattataacc atataaatca tataaatcaa tactcaaact agccaataga caagtttcta
    19921 gaaaaataat aaatttatac gtgaaaatga ctttaagctc cattctccaa caatcggaga
    19981 ctttaattag tatttaataa tgaatcttaa tgtttaatac aatattcaag aattattcaa
    20041 aaatacttaa gtattatagt ctagtttgta aagatattat aaaataataa taccagttat
    20101 atatgaaaat aaaacattat aatttgtaat aactataaaa cttggaatta taattaaaat
    20161 acctttgaat ggagtggtgt aatgtataat ttactggttg tagatgatga tgttgatatt
    20221 ttaaacataa atcaaattta tttttctaat ataggtttta atgtatatac atcagagact
    20281 gctaaagatg ctatggatat agtagagagt atagttttag actgtataat tttggatatt
    20341 tcattgccag atatagatgg atataaaatg tgcaatgata taaaagaaaa ggttaacata
    20401 cctataatat ttttatctaa ttatgagcat gaagaagaaa aagttcgggg atttttagct
    20461 gggggggatg attatataac aaaaccttat agtttaaaag aacttgaact tagaatatat
    20521 gctcgtatga ggcagtacaa aaatattaca tcagttccta atgtgttaaa gttttcagcg
    20581 ttagtaataa atgtaaattc aagaaaagta acttttgatg gagaaagtat agatttaact
    20641 actatggaat ttgaaatatt attgtttcta gctgagaaca aagaacaagt attttcaaag
    20701 atagagatat ataaccaagt ttggaaaatg cctgatattg gagatcaaca tacagtgcag
    20761 gttcatattg cacagatgag aaaaaaaatt aattctttaa gcagggagca tcaatacatt
    20821 caaaccgtat ggggaaaagg atataagttt gtaccataag tgagatactg taattaataa
    20881 atagttcttg ttttatttaa tacgactatg aaagagatgt ggttgatgca atgaaaaagt
    20941 ataatatact aaaaggaact ctcattgtat tgatagtctc tctgttggca ataacaggat
    21001 taaatcttct gtataaatat gataataaat atacatataa gtctattaga gcaagtaatg
    21061 gaattttaac tatagataat gatactttca ctaaagggca acttgtcttt ttgatagatg
    21121 actgggagtt ttataatcat aaaatattta aaccgaatga ttttacagag caagatataa
    21181 aaccagaata tgtttttata ggtcaatatc cagatttttc tatgagaaaa gggaatcagt
    21241 caccatatgg gaatgctact taccgtatga gaataaaaaa tgaaggcaag gataagctac
    21301 taagtttaga gcttcctgag attttttccg caagtgaagt atggataaat ggagaaatgg
    21361 tttctaaatt aggagatgta ggaacagaaa aatatagacc caaaattaaa aattcagtag
    21421 taagttttat tgcaaagaaa aatacagaaa ttataatcaa tgtatcgaat ttttcacatt
    21481 attatagtgg tttgtattat ccgcctgcat taggagaaac aaaggacata agtaatatga
    21541 tgttttatcg attacttttt tatagtataa tttgcttcac aacttttgca atagctatat
    21601 tttcattgtc tgtatggttt ctttcaaaca aaagtaaaat ttacttatat tttggatgta
    21661 tgtgtgtttt ctttgccatc catgtatcct atccctttgt acatttgtta ggactgcctt
    21721 tagtaagctt tacatatgcg gttgaagatt tgtcatattt tatggtagtt ttatgtatta
    21781 tttgtataaa tggaagtata tccaaaatag aagaaaataa agtgtataga tttttaattt
    21841 taccattagg aattacaatg agtatcatat ctatagtgat accaattatt cttcttccat
    21901 atgatatgta ctttgtcaac atatatggga agttaataga catatataaa tatattgtat
    21961 ttatatatat attaatgtct tcgctggttt caatatataa aaagacatgc tctgagcaca
    22021 taagttctta tattttagtt tcagtaaaca ctgtttttgg aattagcata ttatttgatg
    22081 cagttacgag taatagattt gagcctatat ttacagggtg gcaaacagaa tattgtgggt
    22141 ttgtaattgt tattttattt tctgttatga tgataaacag gaatagaata ataataaaag
    22201 agaatgaaaa acttacaagg aatcttgaac atgaagttga agtgagaact aatgaactta
    22261 caacattgtt aaatgaacgt aaaagattct tggcagatgt agcacatgat ttaaaggcac
    22321 ctgtttcggc tatacaagca tttatagatt tgataaaggt tggtaatatt catgtagatg
    22381 aagagacaag aacctatctt tatgctataa atcaaaagtc aaatgaagta caaaatagag
    22441 tacgtagttt gcaagaattt acatcacaag ataaaagcat tggtattagt gaaaaaatat
    22501 gtctgaataa ttttattaaa gagatatatg aaaataattt gccagataca caagcatgtg
    22561 gtgtaaactt tgaagcttac gtattggaga aaaaaatata tgcaaagata aataaagaga
    22621 tgcttacaag agcattcgag aatttaattt ataatgcttt gacctttact ccatttgatg
    22681 gaaagataat tttatcaatg gataaagaag atggatttgc aattattaaa atttctgata
    22741 atggaaaagg tatacctcca gaaaatatac caaaggtatt tgacagattc tttacagaaa
    22801 gagacaataa tgagccaaaa gggcaagggt tagggctata tattgtcaaa tccattataa
    22861 gagagcatgg tggagaaata tttgtagatt cagaactagg aaaaggaact gtttttacaa
    22921 taaaattaag tctatgtttt ttataataat agcttattta atataaaaga ataatgatat
    22981 ttgggagtga ttataatgca aactaagata ttgataatag atggagacaa ggataattgc
    23041 cagaagctaa aaggatttct ggaggaaaaa ggaataagta tagatttagc atataattgt
    23101 gaagaagcta ttggaaaaat atttagcaat aaatatgatt taatattttt agaaataatt
    23161 ctaagtgatg gtgatggatg gactctttgt aaaaaaatta gaaatgtaac tacttgtcca
    23221 attgtttata tgacttatat aaatgaagac caaagcattt taaatgcttt aaattctggt
    23281 ggagacgatt acttaataaa gcctctaaat ttagaaatat tatatgcaaa agtaaaagct
    23341 attttaagaa gaatgaactc atatgtaaat aataatgaaa ataatacaaa attagaggaa
    23401 tataatagaa ctagtggagt aataaagtta gaagataaaa taataaaatt gactccaaca
    23461 gaaaataagt tgttaaactt ttttatagag aatcctgaaa agactttgac tactaaagag
    23521 atatatgaac atgtatggat gaatgaatac ttagaggata actatagtgt ggtagttgca
    23581 gtgaatggat taagaaagaa aatagagaaa gattataaaa atcctcagaa aattataaca
    23641 ataagaggag caggatatta ttttaataag gaataataaa tatatataaa caaacataaa
    23701 taagtattaa aacgtgcagt tttagcggta tttaaaagaa attattataa actaactgac
    23761 tgacatttaa ctgacaaaac ctattttttt aggttcaact gacatttaac tgacagtcag
    23821 tttttattat ttaaatagaa gtttacttaa attatcagaa gcttctttgt ccatttcctc
    23881 taaaacatga gagtacctat tcatagttat ttttatatct gtatgaccta atctttctga
    23941 aacaactttc atatttgtac ctcctagcaa aagcaaactt gcgtttgtat gtcttaaatc
    24001 atgtactcta atatttctta aattatttct tttaataaag ttatgaaaag ttttacttaa
    24061 tgcagttggt atccaaggtt ttaaatttgt atttaaacat actaaattat tttcattttc
    24121 aagtgtacct tgtaatttca ttttgttttg ttttaatttt tctattttta gtttttcaat
    24181 taattctttt ggaactgaca acgttctttt tgattttgca gtttttggtt ctttaaaagt
    24241 tattttacta tttgcatata tgagaatttg gttaatattt attatactat tatctaaatc
    24301 aacatcagac catctaagac cagctacctc tccaattctt aaacctaaca gcaacattaa
    24361 gagaatgggt atctctatca aactatcttt caacttctct attaacaata gcgtttcttc
    24421 tctattatat atttcaattt catatgtaac attttgagct ggcaatttta caaaatcgca
    24481 aggattttca gatatttctt ttagcctata agcctctttt aaaacagaag atagaaaatt
    24541 atatctgact tttgcacttg aggaagtaga attattgaaa cttttattta taaagaattg
    24601 aagtaaacta ggatttatat ctataagttt tatatcttta aaaaaaggtt ctatataatt
    24661 attaacccaa gattttctat ttacagttgt gtaaggagac caattttttt catttgcaat
    24721 tatgtactta taacatctct ctacaagtgt tattttgttt ggagttataa acttattatt
    24781 gtttatagta gactttattt caattaaatg tttttcagca tcctttttct tttcatagct
    24841 tccataactt ttttgcttta ttttgccagt tgtttcttct atgtactcca catatacatg
    24901 aaatttttcc cctctttttc ttataaaagc tgatttgata ttcatatatg tacactcctt
    24961 tataagtatt attcatgttt aaaatatatt gaataactat ggttttatta tatcaaatct
    25021 aagttataaa ttctattcga tgatagagta gatgtataca gaaatatata gacaaatctt
    25081 taaaaaagta atatataggt aaaatatgta agaattatat gttataatat ttttagcaag
    25141 gaaaataaaa ttgaaaagcg aagggtgatt ttctcatata aacgccaaat tccaatatag
    25201 gaaggaggtg aatttatatg ttaattaact ttttattgag tatagtagct ggtattgtat
    25261 cagctttcat atatgacaaa ataaaaaatc acccaaacgc caataagggt gatttaaaga
    25321 aataactttt aaattctaat caattagaga aattcacctt ttaaaaagta aattttatct
    25381 ccttgctatt attatatcac aaattggtat agatattcaa aaataatatt ttattaaagt
    25441 ataattgttt gaatatattt aagctaattt attatttaat tcttgtattt ttaatgtttg
    25501 tctatattct tgtgcttctg ccaattttgt atattccaca gtcttatcga aatttttctc
    25561 aacttctgtt cttatttcat caagcgtaac tttgaagaat tcctttctat tatttacctt
    25621 gttaactctc ttattatcaa aagctttatg taaagctgat tctaatttag gtgcatcttc
    25681 actaaatata gtcgcatgta tatcatattt aaaaggaact gatgcactac ttaattcatt
    25741 tattctctca gttgggtcta atcttctagt tactcctatt ttatatatat tttctccaaa
    25801 actaccaata ttggagatta tgtatacatg tcctgctctt gtattttgtt ctctatttaa
    25861 tacatcatct aaatcttttg atagcaaagc tagtttttct tctatagaat taattttttg
    25921 ttcccattct aatttatcat tttcatcttc tgggatagtt gattttagtc taagtaattc
    25981 attcttgaat tgtaattctt ctttttttag ttttcttttc tgattttcaa tttctttttg
    26041 aacaagagct tcttctttca tttgttctct caaagctctt tgttcttctt tttcctcttc
    26101 tttcatttga aggtattcat aatataaata aagctcatct attttcaaat taagatagtt
    26161 ttcttttata gaaaccttat ttgaagtatt taatttattt gtatcagtaa atgcttttcg
    26221 tattcttttt tctatagaat caatattttt aaaactaact tttgacatag caatgtcgca
    26281 ctcactattg aagagtttaa gagctgtttt aatattttga ttagtcatag ttctaccttt
    26341 ttgaacactt ccatcaacag tccaagaatc agaatatttt acacctgttt tatttcttat
    26401 taatagtttt tgcatttctc ttatttcttt taatttttcc atatattcat cagagttttc
    26461 aaaatcatat tttggattat ataatccaaa tgattgaagc agaacctcat cttcagtctg
    26521 tattaattct tctgataatc tttttagctc ttctttttta ttttttaaag ttgtgtttat
    26581 atctctaagc tcttcccttt cattttttaa ttcttctaaa tgagaattta aagtattaat
    26641 attatcttta agtatatttt tatcttttat aagattatca agtctttctt tttctatttt
    26701 tagttcttcg ataagtttaa atttatcttg gttttctgaa tcaaatttat caatttcaac
    26761 tttctttttg tctaatagat tggataattc ttttaactta ttttcatttg attcacataa
    26821 atcttcaaag tgtttttctt tcattttaat ttcatcattt aataaaatat atttattatt
    26881 gattttttcg acatcagata atagtatact aatgctatct ttatgttttt tcattatctt
    26941 atttctttta aataagaata ttattgcaac tataaatgat atagagtatg ttgaaaacgt
    27001 agaaagaatt agtatggata tagtccataa agaataatac cagggtatct tgaaattaag
    27061 atttttgatt ttttcatcgt tgatgagtaa atcacttttt aactgttcat tttcattgtt
    27121 catatcaaaa ctcctttttt attttttgtt ctactttatg ataataataa tttaagtata
    27181 taaaatttta tgtgcaattt ccatatattt gcaaaaaaag gtaaaaataa aacaaaatgg
    27241 tagttattta aaagaattta gttggattat aaaggtatgt taacagaaat tagaaaaata
    27301 atataacatt cttataaaag tatgttatca gtattttgag cataaggaaa agccacttaa
    27361 aattagtttt aatcatttta agtagctctt ttattatttt agatactcct ttgaatattt
    27421 aatccaagca tcaataccat cgattaagtg aattaattcg ccataaatat gttctgaacc
    27481 aaattcattt ttcatgtaca ttatccattt ttttctacct tgcaatttaa ctttaccaat
    27541 gaagttgtct gaagtatcaa atacattaaa tgctccatct gacattctat caaagacaaa
    27601 attatttttt aattcatttt cgtacatttt aattttaagt atattaaaaa agtagatttc
    27661 attttcatta attttgaagt tgtaattttt attattaact tcgaatggta ttgatttgtt
    27721 atttttaaca atatccatat aatgtaaatt tttattatta atactatcat ttgcgttata
    27781 tgttatagta gagtgattgt atattacatc atttatacta tttatagcat tattaatttc
    27841 gatattatca attttttctc ctgccaaacg ttttactaat atagaagttt tggagttatt
    27901 tcctaacata tcacaaagta tataggatga tttaattatg ttatctaaaa gtgtgtcttt
    27961 taaatttata tctaattcct ttatggcttt gtaagactca attttcatag gtgtaatttt
    28021 atgattttcc cagtttatat taattcctct ttggatattt ttagaggatt catatttaca
    28081 aattaagtca tatgcttcct catatttatc aatataaatt aattctaaac actggtcttc
    28141 taggtcagta tttttagtaa cagatttacg cacatctttc aacagttctt ttcctttatc
    28201 tgttaaagca taatatttgt tggagctatt aaaaaaatta gataaatctt tgcatgagat
    28261 ttctttttct atcctttcta ttaattcagc ctttttacca gttgatttaa tattattaga
    28321 ttttaatatt tctttcaatt ccgaaactgt taacttagta aggtcttcaa tgtaatttga
    28381 aatcttaaga taatccatgt tgaaaaactt agaaattaaa tatgaatagt taatattata
    28441 ttcatatgtc caataggttg ctatataagg ctcgtatata ttttctccaa ttatgtattt
    28501 taggaaagat ttttctattg atgtaagtgg tttagtatct gtttctaata tattgttttg
    28561 tgggttaaac ttattaatac tattagtatg tatatcatat aaagcatctg atttttctct
    28621 tgcttgtttt tctaattcat ataaatttgt tgtatcatta caacttacat tcagcacttt
    28681 attaatttca ttttttactt ctatgttatg aggtgaatta gaattacatt ctagtgaaag
    28741 tgtagtacta tcattatagc tttgttttga ttcgttcgat ttttcattgc aatcaacatt
    28801 atttttgttt ttattttttc taaatagatt caaaatgctc ataaaaaatt actccttttg
    28861 tatttaatta atttctagtg tattctactt tgtgacaata acaatttaag tatataaaac
    28921 tttctgtata aatgctatgt atattaggaa aaaacataga attaaatagt tttgaaaaga
    28981 atactatatt tatatggtat aaaaagtaaa acgaagattt taaaattaaa taataaaaaa
    29041 tattatataa acaagaaaat acaaaaaatt ataattaaaa agacgattaa taatacacag
    29101 gaatggaaaa aataaccaag actctacaaa attcgatttt tttgttacaa ttcccctttt
    29161 tttattgcat atatttaaca aaagtattat tatgtaagta agataattat ccaagaaaat
    29221 tttgaataat ctaaaaatat ttttagaaat gaaaatacat agttatattt tattgaaatt
    29281 tgttgggaat tttaactaaa aataagaaca taagttctga tagtaggggg aaggcgtgtg
    29341 gaaaaatcaa aaaaactact aattgacaca ggggatacat tgaacaaatt aagagaaaat
    29401 aatagtgaga agttagaaaa gtacatagaa ttattaaaag aatattataa acaagaaaat
    29461 aaaaaagaaa gagaatagtt ttcttctctt tcttattttt tctcattaag ttcttcttca
    29521 agaaatactt ttgctatttt gaacattttt tcttgactag aaggacttaa ttcgctaatt
    29581 agttttaaag cttcttttat atcatcagag aaatttagat tttcaattag ctctaactca
    29641 ctaagattgt ctatattttt tacattgacc tttccaagca aataatctgt agatacatta
    29701 aaaaaatctg ataattttaa aattatgtca tgtggaggaa atctttcttc cttctcataa
    29761 aaagaaatca ttttaggagt aagacctaaa aaagttgcaa gttctttttg agtaatatct
    29821 ttttcttttc ttaattcctt tattctatat ccaatcatgt tatttagcca cctttttaat
    29881 ttatattgaa ctattagttc ttaattatca attatagctc atttttttta aaaaagctat
    29941 tgacaatgta ctaatagtac tgtactatta gtacataaga taaagtaaaa gaaggtgaaa
    30001 aaatgaataa actaaaagat tttagaatac aaaaaggact aagtagaaat cagttaggag
    30061 ctgaattagg tcttacaagt aggtatatag ctttcttaga gaatggcgaa agagtaccgt
    30121 ctctaaatac agctgtaaaa atagcagctt atttcaatac ttcaatagag tatatttttt
    30181 tgaaaaacaa ctgtactaaa agtacattta aagaaaaagg agctgaaaaa tatgaataac
    30241 ttacaagtaa tagaaagaaa taacgaaaga gttttaacta cacagcaact agcagatgta
    30301 tatgaaacag atgcaagaaa tataagcaac aattttaaca ataacaaaga tagatttatt
    30361 gaaggtaaac attatttttt attgcaaggt gatgatttaa aaaattttaa aggtattcat
    30421 acagaatatg aaaacctaaa atttacttca aaaatgtatc tttggactga aagaggagca
    30481 aatagacact gcaaaatatt ggatactgac aaagcttggg agcagtttga taacttagaa
    30541 gaaacatatt tcaaagttaa gcaacataag ccaacttgta tagaagatgt attaatagaa
    30601 agtttaaaag aaatgaaaga tttaagactt caagttaatc aagcaaatag cattgcttta
    30661 gaagcaaaga cagaggttga aacaataaaa gatgtagttt cattagactc aaatagttgg
    30721 agaacaaata cacatcaact aattgcaaga atagcaaaaa aacaaggtgg ttttgaacat
    30781 ataaatatgc ttagaacaga aagttatgaa ttattaaata agcgatttgg agttgatttg
    30841 catagaagat taattaataa aagaagaaaa atggcagaag aaggtgtatc tgaatctaaa
    30901 agagagaaag ttaacaatct agatgtaata caagatgata agaagctaat agaggggtat
    30961 gtggctattg taaaagatat ggctttaaaa tatggaatat caagtgattt aagcaaaaat
    31021 taggttaaat catgacagta ccttgaaaac taaatacaga atatttaatt aatatgagaa
    31081 ggaggtttga aaatgagtgt agcattacag tttatagata cagaagattt agtaaaagaa
    31141 ttaatgggac gagaggatac agtagatttc ataaaaatgt ttttagatag agaaggaatt
    31201 aaaagaatgg agttaatgac tatagaagaa ttttgtgagt acttgaaaat atctgatgta
    31261 acagctagaa acatggcaag agaagccatg ataacaaaag attttattgc tttaaaaata
    31321 ggaagaaagt acatgattga tagaatatca tttgaagaat ttattatgaa aaatgcaatg
    31381 aaagatagag atgtaatgaa aaaaagaaag ggggtgattt agttgactct aagatggttt
    31441 ctaagatttt gtataagaca caagaaagta cctacaccaa agttttacat agagtgtgta
    31501 acttatatgg aagaatgtaa acaaagagga cttggacttt aaggaggatt gaatatggaa
    31561 gtaactaaaa gatttttaga atataaaata caggctctaa gcgagaggat agaatttaaa
    31621 aaaacaattg gatataagtg tatagcagat gaaaaagaac taggagcata tgaggatatt
    31681 ttgcttatgt taaattcaga aattgaatca ataggaggag tggaaaatga agagtagaca
    31741 agaattaatc aaagatatag aaaaatacag aaaagcacaa tacttaatat atttagatat
    31801 agtacaaaga gcatgggcag atagaagcct tacagcagat gaacaagaca gaattaaaca
    31861 agaagcatat gcagagtaca aaaggataga aagagataca gaagaagcag aagaactgct
    31921 aatgagagaa gaatttgaaa cagatagacc cttagcagtt caaataatgt agaaaagagc
    31981 cactgcaatg gctctaatca aaaacaaaaa ataaatttaa taattatata ttatagcata
    32041 aatggaggga aattatgagt actttatatg aattagctac agatttatta gaaatagaag
    32101 aaggtttaac agaaacaaca agaaatgaag ctgaaaaact agaggaaata aaagaaataa
    32161 taaaacaaga gatacaaaat aaaaacacta ggatagtttc agtaatatta aacattgaca
    32221 gtgatataaa ctctatagat tcagagatta aaagattgca agagttaaaa agggtcaaaa
    32281 agaatactct tgatagatta aaaagcaata taaaagactg tatggaatta cttgatacta
    32341 aaaaagtaga aacattttta ggaaatataa gtataagaaa gtcagcaggt agcttagtca
    32401 tagaagatga agaaaagata cctgctatat ataaaacagt agagcaagtt gtaaaagtag
    32461 ataagaatac cattaaagac tttattaaaa aaggtcatga ggttgaaggt tgtaggattg
    32521 aatattcaac tacattaaca actccaaaag ttaaaaaaga gtaggtgaaa actatggaaa
    32581 ataataatat ttatataaaa cttgtgaata tacagagtac tttaaaagct cctaaaagtc
    32641 aatttaatag ctttggtaaa tacaactata ggagttgtga ggatatacta gaaggtttaa
    32701 aacctattct aaaggaagaa aaagcattag ttatattgga tgataatatt gttcagatag
    32761 gaaatagatt ttatgtagaa gctacagcaa ctttaataga tgcagaaaca ggagagaaag
    32821 tatctacaaa ggcattagct agagaagatg aaactaaaaa aggtatggat ttagcacaag
    32881 taactggaag tgtatcaagt tatgcaagaa agtacgcttt aaatggatta ttttgtattg
    32941 atgatacaaa agatagtgat gcaacaaata aacatggaaa tgagcagaaa aaaaaagaag
    33001 ttaatgagag tgaattaaat acactatatt cgctaggaga atctatagaa aaagataaaa
    33061 atagagttga tagtgaagta tataagaagt ttggaaagtt agcagtagat ttgactaagc
    33121 aagagtatga gaaagtttta aatggatata agagcatttt agagaagcaa aaacaagagt
    33181 aggtgatagt attggggatt ataagagtaa gcaaagacaa ggataatcca tatgtagttt
    33241 taaataaaac ttgtttggaa gatgtgaaat taagctggca agcaaaaggt ttacattcat
    33301 atctgattag taagcccgac cactggaaaa tctatgttaa tgacctttgc aagagaagta
    33361 aaaatggaag agatgctaca gcaaatattt taaaagaact tatagaaaat ggatatataa
    33421 caagaaaacc ttgtagagat tctaatacta ataaaatgct tggagggtat gattatgaag
    33481 tatatgagat accacttgaa aatcctcaga agctaaaatc ccgaaaaact gatttcccgg
    33541 aaaccggatt tcccggaaac cgggtttctc ggaaaccgga aaacacggaa gtagtaagta
    33601 atgactttaa agtaaataat gatattacta ctattgttat taatgaacaa tccaataaag
    33661 acaaaaccac ctacataaaa aaatactttg aaaaatatat aggtgtgatt actcctaata
    33721 actttataga gttaatgagt tacttagatg atggaatgga agctgatgta attataagag
    33781 ctattgatga agcaatagca aatggagtta agaattataa gtatgtaaag acaatattaa
    33841 ataattggat agaagcaggt gtaaaaacta atttagaact tacagagtat caaaatgagt
    33901 ttgagaggaa gaaaaagaat aaacaggata agaagcagtc taatagtaaa gctgtgaata
    33961 ctcctaatgt gagtaaaaat aagtttcata acttcaatga aacatttact caatattcac
    34021 ctgacgaact agatgacata attaagaaaa gccaaaaggt taaatttaaa taaaattaaa
    34081 cttctaggaa gtaaatatca atatattgct tcctagaaag gggaggtata aatggcgaga
    34141 atatatgcac aaagaagtgg ttctttaaat gaacaagata gattggaatt attaagatta
    34201 cttgggaaag ctggatatac agtaaagatt gctagagaga agcaaaatag caagacaact
    34261 tatacttact ttgttgagta tacagaagag caagaagaaa aatagaaggg ggctagttaa
    34321 atgaatacaa taactttagt tggaagatta gttgcagatg cagaattgaa gtaccttcca
    34381 aattcgggta ctccaaaaat aaccttttca atggcagtag atagaaggtt taaagataaa
    34441 aatggaaata aaataactga ttttattcaa tgtgagcaat taggaaaaca tgtagagaat
    34501 ttagtgcaat atcttgttaa aggtaaacct atatatgctg ttggagagtt aaatatatat
    34561 aattacaaag atgaaaatgg ttgctggaaa tctattacta aagttaacgt gaatgcttta
    34621 gaattacttt ctagtaaaag tgatagtaat aatcataaag agcaacagga atatatacca
    34681 ccaggactgg acccacaagg ttttcaagca atagatgatg acgatatacc tttttaatta
    34741 agttaaataa tctagggagt aattatgcaa tattacttcc taggagttaa aatattggag
    34801 ggatggaaaa tggaagaaga gtatagaaaa ttttttttag agcgtaatgg tgagaaaatt
    34861 gagatggtac aaaattgcga aggagcaata aaaataagct taaataatat aaaaacagat
    34921 aattcgcata gaccttggaa tttaaaggca gaaggaacag ctacagtgac gctatatcta
    34981 ggtaaactgc tttttgaaga aatgctgtgg cttaaaatat tgtatttatt agaagttata
    35041 gcagaaaaaa tgatgatggg ggtattagga atgataataa ttagaagtca aaataaatta
    35101 gatttaatga gagttaatag agttgaaata gatagtagat atgtatatgc agtgtttgaa
    35161 ggtgaatcaa atgttagaga aataggtagg tataaatcag aagaaagagc tattgaagta
    35221 ttaaacagaa tacaggaggc tattattgca ggaactaagt ttgacattat aaataaagac
    35281 ggggttagat gcaacaaaga aaaagtgttt gaaatgccag ttgaataagg agggggctga
    35341 aatgttaaag gttgaaagat attttagtgg ttctgttgca gataatatat ttgaagatga
    35401 tttgactctt agaaattatt tagcactata ttgctgtatc tatggagtaa acaaaaatgg
    35461 agaacttgta tttccaacac gtggaaaaat gctaatagag tttaatgttg atagggatag
    35521 aaaaaagaga aagaaagctt caaaagtaaa gttaattaat gtcaaaactg gtgaagaaaa
    35581 aatatttgat tctatagata gtgcagcatg ttttttaaga ctacagagtc aggcagttta
    35641 ccaaacaatt aaaaagaaaa ctaaaacaag aagtggctgg aaagctgaat atattgagga
    35701 ggaataatgg aagtttcaag gactgaatac acaattaaaa gagcaaaaga gttatatgat
    35761 aatggagagg atatatttat tgctatagat aaggctagag aagaatatga ggagatggtt
    35821 aaaagtgaat atcttagcta gtgtgatatt agtaatagga agttttatag ctggtagagt
    35881 ttatgagtat agattgaatt taaatgaaaa tgatgaagct gattcaaaag tacttttaga
    35941 tgtttttaat gaaattagtg tgttaagaga agaaaataaa agtcttaaag aaaagttaca
    36001 agagaaagag ttactattca tcaatagatt aatagatttt ttacatgata aaaagatatg
    36061 cgaatgttgt atttatgact gtaagattga tgatattgaa tatgattgtg aagatggtat
    36121 taaaaagtgg cttgatagcg aagaacttat atttgaatag aagaaatatc taattaaaac
    36181 agtttagaga gttgcaaaat gttttttaat aaaattatca ttgagatgtt ttgtaactct
    36241 caaaaatgaa aataaggagg cgttgtattg cttacatttt tagatttatt cgcagggata
    36301 ggtggcttta ggctagggat ggaaaaagca ggacataaat gtttgggaca ttgcgaatat
    36361 gataaattcg caaatttaag ttataatgcc atgcacaaac cgaaggagga tgaatggttt
    36421 gaaagagata ttagagaaat tagaacagaa aatatcccaa gagcagatgt ctggtgtttt
    36481 ggattcccat gtcaagacat ttctgttgca gggaaacaat ttggattcag aggagaacgt
    36541 tcaagtttat tttttacagt tacaaaactt attagagaac tcaaagaaga agatagaccc
    36601 aagtatttac ttattgaaaa cgttaaaaat ctacttagtg ttaatggagg atttgatttc
    36661 ctcaaagttc tcgttgaact ggatgaaatc ggctatgatg cagagtggca agttcttaat
    36721 tctaaaaact tcggagtacc ccaaaataga gaacgaatat tcattgttgg acattttaga
    36781 ggacgaagta cacgaaaagt atttcctatc gaaagaaaaa gtggaaaaaa tcttgagcaa
    36841 ctaaataatc caactcatag tacaaataga atttatgatg cagttggaat tgctagatgt
    36901 attagaagtc aggcaggagg tggaggtgct aaaacaggtc tatactttat agacttaaat
    36961 aaaaactcta aaataacaat aaatgctaga tatcttaaaa caaaatataa tgcaggtgtg
    37021 acaaatagaa attgtgataa tagtggagtt ttagttaatg cagttttaac gcccgatagg
    37081 gtaaataaaa gacaaaatgg tcgtagaatt aaagaaagcg gagaaccaat gttcacattg
    37141 acagctcaag ataaacatgg aattttgaaa aatggagata taagaaggtt aacaccaaag
    37201 gaatgcttta ggttgcaagg atttccggat aaatattacg aaagagcagc aagtgtatgc
    37261 tcagatagtc aactgtacaa acaagcggga aatgctgtta ctgcaaatgt tatatatgaa
    37321 atagcaaaaa gaatgggcta aaagttgcaa aatgtctttt agtataaatt attgttgaag
    37381 tgttttgtaa ctctcaaaaa ctaaaataaa gggggaatta aattgcaaaa atataaaatt
    37441 aaatttgagg aaaaagtgac tttagaacat gaagttatag ttgaaatacc agaagaaata
    37501 agtataaatg acatttgcca ttgtatagaa caaaagtgtc aaagaatata tgatatagca
    37561 gattatataa gagaatttaa tgggagacaa atagatttta cagaagatac ttgtggaggg
    37621 actgaaatgt tagttgaatc atttagaaaa tgaaagtagt gagcatatga ctaataaaga
    37681 tatgtgcaag tcaaagaatc ttgatgaaag agaagtgtat aagagttttg ggaaagagat
    37741 ttgtaaatga taaaggagat tgtgaaagta aagattgtga tgcaacatat gaaaattggt
    37801 tggagaagga tgctgaaaga taattataaa aataaagtca aggtaagctt gtgaatgaaa
    37861 ctagaagtct atagacttac tttgacttat aaaaaggagt ggtcaatatg gttattacag
    37921 aatttaaggt gacttggcag acaactagag aatgggaaaa agggaacgtg tacagctcta
    37981 tatttactaa tttagaagaa gcaagagctt ttaaaaaaga tgaggaaaat ataaaagaaa
    38041 attataatgt gaagctttta agtagagcta tagtcgaaat cgaaatagat taggtaggtg
    38101 tttttaatga atactctgat atataaatat atagttaatg aacatagaga tgaagcagat
    38161 gagttagata gagactatgg agaatttaaa atatttaatg gaggtaaatg ttttggtgga
    38221 tgtggtagga atttctatac attagctaag tttaaaaaaa tgatagttac ttgtccccat
    38281 tgtggaaaaa aatatcaaat aaaacttttt aaaaatggaa aagtgaatat gagagtaatt
    38341 gagtaaatca agggaagtga ttatatgaaa agaagaagat gcagttggtg tggcaaacta
    38401 ttttatcttg atgaaaaatc taaggagatt tattgttgta aggaatgtag gaagaaggct
    38461 aagaaggtga aaaaatgaaa gtttttcttg taatagatgg agagccagtt ggcaaagaaa
    38521 gacctagaat gaactctata actaaaagga tctatacacc taataaaact agagattatg
    38581 aggagttaat aaaatggctg tatcaatcta aagtgaagta tcgttttact ggttatataa
    38641 aaatgacttt aagatgttat tactctatag ctaaaagtaa cagtaaaaag gttaaggagc
    38701 agaaaagaaa taatgtgtta agacctagta aaaaacccga tattgacaat gttgttaaga
    38761 ttatagctga ttcactcaat gagatagctt ataaagatga tacacagatt gttgaggttg
    38821 tagctagtaa atactatagt gataagccaa gggttgaggt tatattagaa gatattattt
    38881 aaggaggact ataaatatga atgagattat gacaaatgaa aatttaagag ttgtagcaga
    38941 tgatttagtt acagtttatg aaactgatac aggagagaaa atagtttttg caagagaact
    39001 acataataat ttagaagtta agagacagtt tatagactgg attgaagata gaattaaaca
    39061 atatgggttt aaggaaaatg aggattattc agtttttcac aaaaatatga aaaactcaac
    39121 tggtgggaga ccttcaaaag aatatgtatt gaagcttgat gtagcaaaag aacttgctat
    39181 ggtacaaaac aataataaag gaagagaaat aagaagatat tttataagat tagaaaagtt
    39241 actaaataga accttatcaa attcacagct tagtcaaatt aatactattg tgaatgaatc
    39301 attacttaag atggaagtta aacataatat ccaaatagag caacttaaaa aagagtgttc
    39361 agaatattat agaccaacct ctaaaactaa atatgatata tcttcttata taaaagaaag
    39421 actaggtata tcaaaagtta atgaagaatt tgaattagtt aagaaaagaa ctctattggt
    39481 attaggtgct gacaaatggg aggatatccc gaaagatgta ttacttaatt cattaaactt
    39541 aatagatgaa tcaatcagaa ttataaaatc tgagagaaaa acaaatcaaa ttagtttctt
    39601 tgaaaaagat aatttctgtt aataaaaaga aaaaaggagt gctttcacac tccacttgtc
    39661 aaaaatataa agcttttatc caagattatt ataacataaa caggagtgtg gaagtatgga
    39721 taataatatc aataaaaaag aactatttaa aaaagtagaa ggtagactac atcattataa
    39781 atttttaagt gcagaaatta aaaatcttga attagatata gaaagtagag aaaatgagat
    39841 atttgggtgt aaggctgttg gatatgatga aaaagtaagt ccaacatatg cttttaattc
    39901 aagtgtggag aatgagatta taaaaaaaga aagagatatt actagattga aaaaactgaa
    39961 aaaagataag gaaattgaaa agaagaaaat agaaaatgca cttacatgct tagatataag
    40021 agaagaacat ttttttaaac tgttttacaa tagcagaatg aaaaatagta tggtttatat
    40081 atcattagag atgaactcag atagaaaaac atgtagatgt gtgagggaaa gattagtgta
    40141 taaaattatg gatatgcttt atccaagaat taaggaaaat gaactaccat tatttaaaaa
    40201 ttagaaaatt ccccagtttt tccccagaaa ttcccacttt attccctact ttctcccctt
    40261 tttgattaaa aaagcatgag ataatagtat tgtggaaata aagatttccc tctcaaaact
    40321 taatatttga ctagggtata agggattgcc ctagtcacta cgaacagact aggcagggcg
    40381 tgaggacgct gttagttcaa ttctaactat gttcaaatat taatcaacgt atacactaaa
    40441 agtagagaaa ttgagggcaa aattttatat tttgtatctt aattcagaag tctaaaaatc
    40501 gggtggggct tggtaacctc actcaccatg caggtactgg tgtttaatct aagttcgatt
    40561 cttagaactt gcgacataat atatgtatct ccctatttaa aaaggctaag tgagggtaag
    40621 cttagtcttt tattttttta caggagtatg ataaatgagt aatttaagag aaaagataat
    40681 aaaagaacta aatgaattta atataaaagc agataatgat tttttagaat atgcagttga
    40741 acacattaaa aagtttatga atgaaggtat agctgatgaa gagttattaa taagaggagt
    40801 tgtgcttgga gcaagttatg tagttaatat agaaaataaa gacttagatt aatttctagg
    40861 tctttttttt atacaataaa ttaaaaggag aataaattat gaatgattat aaagaaaaaa
    40921 ctgaaccaaa attaaatatt ttagtccagt ctaaagttga tatcttatgt tctaatagct
    40981 ctactatgaa tggagtagac acttcaattg atataaaact ttctttagat aatagagtta
    41041 ttggcaattt aactaatgaa gacataaaaa aagaaatatc aacatctttt aataagtgtt
    41101 taaaagaaat tgataaaaaa atttgtagca aagaagtaat taataagctg atttgatttc
    41161 ctcaattgaa gaaattagtt gttcttgaac tttttctata attaattctt tatctaaact
    41221 tccagaataa aaaggttgca ataaatcaat gtaatttaat tagatacata gactctaaca
    41281 agagttcttt tttattccca aaacgacaaa caaacgaggt ggtggtgtgc aagatgtgaa
    41341 agaaaaagta aaacaagatt acctaaaagg tatgaaacaa aaggaaatat cagcaaagta
    41401 tgacattagt ttaaatactt taaagtcatg gataaaaaga tacaattggg ctaatgagaa
    41461 aaagaagggt gcacctaaaa ataaaagagg tgcacccata ggtaataaaa atgccactgg
    41521 tcctcctgga aataaaaatg ctgaaaagtt tggtttcttc tcaaaatatc tacctgaaga
    41581 aactagggaa ttaatacaag aaatatctat aaaagataaa tttgatattc tttgggagca
    41641 gataacaatc caatacgcag caataataag agcacaaaag ataatgtatg ttaaagacaa
    41701 ggaagaaatg attaaagaat taaagaaaca tgaaagtaca gaaaatggag agaagataga
    41761 gtatgaattt caatttgcat gggataggca agcatctttt cttaatgcac agagtagagc
    41821 tatgagtgaa cttagaagtt taattaaaca gtatgatgaa atgattcata aggattggaa
    41881 tttggctaca gaggagcaga aaaatagagt tgaaaagtta aaatgtgaag ttgataacct
    41941 aaagaaaagt gatactggag atgattcaaa aatttgggtt gaagctatac aaaatattgc
    42001 aatgaaacgt ggtgttaaca atggataaag ctttattgac actattagat tgttattggg
    42061 ataatcctgt ttggtttgca gaggatatgt taaattttaa agctgacaag tggcaatctg
    42121 atgttctgat ggctttagct caaaccccaa aagtatctat tagaagtggt caaggagtag
    42181 gtaaaactgg attagaaagc attgcaactg tatggtattt aagcactaga ccttttccga
    42241 aagtagttgc tacagctcca acacgacaac aattatatga cgtactatgg gctgaaatag
    42301 ctaaatggct aagtaatagc aaggttgaga agctacttga gtggactaaa acaaaagtgt
    42361 atatgaaagg ctttgaagaa agatggtggg ctacagctag aacagcagta aagcccgaga
    42421 atatgcaagg ttttcatgaa gattatatgt tatttgttgt tgatgaagct tcgggagttg
    42481 ctgaccccat tatggaagct atattgggaa cattatcagg tgcagaaaat aagcttcttt
    42541 tatgcggaaa cccaactaga acgagtggaa cgttttacga tagccataat agagacagag
    42601 atttatataa aacatttaaa gtatcttctt tagacagccc tagaacatca aaagataata
    42661 ttgaaatgct aaaaagaaag taccatgaag gttctgaccc ttggcgtgtc agagtacttg
    42721 gagagtttcc aaaaggtgaa agtgattctt taatatcttt agaagctgtt gaaacaagca
    42781 caataagaga agtgaatata tctaatgact atatattaaa tataggggcg gatatagcaa
    42841 gatatggtga tgatgaaacc ataatagctc caagaatagg tgggaaagta tttgatttat
    42901 taacttattc aaaaaaagat acaatggaaa cagtaggaaa tatattaaga gcagttgata
    42961 aatttaaaaa tatgtatcat caaattaaca gagtaaaaat aaaaacggat gatgatggct
    43021 taggtgcagg tgtaacagat agattaaaag aagttataag acatgaaaga cttaaatatg
    43081 aagttatacc tattcaaaat ggttctagtg ctatagaaaa agataagtac tataataaag
    43141 cttctgaaat gtgggataac atgagggagg aattagatgc aaatttaagt agttttatac
    43201 aaaataaaga agctataata cagcttccta atgatgataa acttattaaa caactatcaa
    43261 atagaaaata tacagtagat tcaaaaggga aaatacaaat agaaagtaaa aaggaaatga
    43321 aaaaaagaat tggagaatca cccgatagag ctgatgcagt aatatattcg tttgcagaaa
    43381 ataacaatac tgatttatct ttactgaaag ggggtagtgt atggggataa tatcttatgt
    43441 aaaaaagcta tttaaaagac ctgcaggaga gattatgcgt atgtctagtg gaaacattgg
    43501 cgtatataaa ttagacgatt ctagagttga ttatgagtta gcaagagaac tgtatcaaaa
    43561 taaaaatgct aagtacaagc taggttctag ttttgttaga ccgattgtca attcaacaac
    43621 tggttttatg ggtgtacctc attttcaaat agaagatgaa gaagctcaat atatattaga
    43681 tgaatttgtt ttagataaca catctaaaat gttaaaaaca catacagata gtttaaagca
    43741 aggtgattgt tatatttgga taactagaga agaaagagaa aatcctttat atcccgataa
    43801 aaaagttaga ttaatatata acttcatatc acccgaagaa gtgaaagaaa taatattaga
    43861 ccctacaaca aaagagccta tagcttatat attagaaagt caaaatgaat ggactgactt
    43921 aggagaaaac aagagaaagg ctaaggtaaa acaaataata actgctgaaa gtagatttgt
    43981 tgaggttgaa ggtgataaga tagaaggttt agaagaaggg gaaacgccta atgtatgggg
    44041 ttttatacca ataatacatt ttaaaaatga agctgatgaa acattgaaat atgggcaaag
    44101 tgatatagaa ccaatagaac ctcttttaaa agcttatcat gatgttatgt tacatgcgtt
    44161 aaaaggtagc aaaatgcact ctactccaaa actaaagttg aaattaactg atgttgcaag
    44221 ttttttagca cacaattttg gtgttgaaga cccagttaaa tttgccaaag aaggtggaaa
    44281 gataaatctt gatgggcatg aaatactatt cttaaacaaa gatgaagaag ctgagtttgt
    44341 agaagtaaaa tcagccatag gtgatgctaa ggagctttta aagcttcttt tttattgcat
    44401 agtagatgta tctgaaacac ccgagtttat atttggagta catacaccta gtgctttagc
    44461 ttctgtaaaa gaacaaatgc ctattatggt aaataagata agaagaaaaa gagaacaatt
    44521 tacaaatagc tggcaattac ttgcaagaat ggttttaata atgagttcta attctagtgg
    44581 tatgaaatat tcatcttatg atgtgactat aggttgggat gaagtaaatc cacgagatga
    44641 taaagaatta gctgaaacac tagaaaaagt atgtagtgca ttagataaag ctttagaggg
    44701 tggatttatt agtgaagaat caacagtaaa ctttttagca cagtatatag atacaatgag
    44761 caattatata agtgatgacc ctgaaatagt tggagaaaga gaaaagataa taaaaaccaa
    44821 gatgttaaaa tacagattag atgactctca aggtttaaat gatgagtcaa atgaaattga
    44881 gaaggaaata aataaaataa aggataataa tggcaatgga taaaagtact tcggaattaa
    44941 taactgttgc aggggagtac aagaaatggg cattagaagc tagaaaaaaa tttatagatt
    45001 taaggctcaa gcaagatgat gaaataagaa caatgtatat taacataaca agaaatatta
    45061 caaaagaaat aagaaaagga aatctttcag actttaacaa agttaggtta aaacagatac
    45121 taaaacaatt aacgcaagaa ataaaaatat taaatgaaca actagtattt aattttgatg
    45181 aatacttaaa taaaaatgtt gaaacagcta ctagttactc taaaaatatt ttaattaatg
    45241 cagttgagac agctcaaata actaaagtaa ctaaaactat gatacaaaaa gctttctatg
    45301 atattaatat aagaactgta gaagcttatt atacaagggt taaggatggt ttatttttat
    45361 ctgatagaat ttggtctaag tgtaagaagt acagagaaga tatgaaagtt atattacaaa
    45421 cagcagtaac agaaggtcaa gactgtgtta aaacagctaa gatgttagac aaatatgttt
    45481 taaaaggtaa gaaaacttta gttgatgaat atccaaatat gataaaaaga ataggaaata
    45541 gagtacctca aaatataagt tatgaagctt taagattggc aagaactgaa atgacatcag
    45601 cttatggtga tggggtttta gcttctgcaa tgattaaccc tgcaaccata ggtattcagt
    45661 ttatgttgtc catggcacat cctcacacag atatatgtga cgaaatatgt ggagaggata
    45721 attttggttt gggtaaaggt gtttatccta taaatgaagc tcctgtatat ccattccacc
    45781 ctcattgttt gtgtattatg cttactgtag ttcaaccatt agatatatta gttggaaggt
    45841 tgaaaaattg gattaaaaat cctatgaatg atgtacctct tgaaatgtgg tatcaagagg
    45901 tgtatggaaa tttgaatttt taaattgaaa ggtggtgatt aaatgaatgt aataactgga
    45961 gaaatggact caatgaatgc gttaatatct agtataaaac cttctgatat tcctttagct
    46021 aaagatatag acatagaagc tttaaaatct atagatgatg accctcttga ggtagttgtt
    46081 gagataccag ctacaaaatc taaaagggga tggaattata ctgctaaaag cttgaaagat
    46141 attgtagatt acactaatga aaatactctt aatggctttt taggacatca aaaagctgaa
    46201 aatatatcaa ctgaatttgc actacctgta acgcattgga taggtgcaga aatgaaaggg
    46261 gataaagctt atttcagagg gctgattgat gctgatgcaa caaatttaaa aagatggatt
    46321 agaactaaaa ggataaaaga agttagtata tttggttatc caaaacttaa aaagagtgct
    46381 aaaggcgaaa tgaatgttat aggatatgag ccactatcta ttgattggac tcctctacat
    46441 agaccaggta tgccaacaag tattgtaggt atggaaatga gtcctaatgg cgaacagtta
    46501 gatggaactt ttgaagcttt aagaatagat ttaagagaag ctttaaaagc taagttttct
    46561 attaatgata ataattcata tctctatata caaaacataa gatatgataa caatactgtc
    46621 atatatgagt tggagcaaaa tggattatgc aagctttata gtataccatt tactatagtt
    46681 gaaaataaaa taaatctagg tgaagaaatt gaagtaataa agaaaataag ctatgaagct
    46741 aaaggagaaa tgaaaggaga ggaaaacaaa ttggaaggaa aagagttaat aaaaaatgtc
    46801 aaaggattac tgcaaactgg tgaaatatca tattcagagg tcatacaagg aataggctta
    46861 actaaggaaa ttgtgacagg agagatggaa gatgtaaaaa gttcattaaa agcagaaaaa
    46921 gaattaagag aagtgaaaaa agtacttgga atagtaggag agatggacac agttgaagtg
    46981 gcaaaaaagg cttcaaaagc tttagaaaat gagaaaaagg aagcttggaa ctgtatagtt
    47041 aataaagtaa ttaaagataa agtgtcaggt gaaatagctc aaacattagt taagaaaatg
    47101 ttaaatgttg aggaaggctc aagtgaagaa gtaataacag gagaaataga aaatatatta
    47161 aatgatgagt ttgtaaaaaa tacaatgtct aatatgtata aagataatcc aacaacaaca
    47221 ggattattaa actctagcaa taatggaagt ttaacaacta agaaaaatag aatataaagg
    47281 agtgatgttt atatggcatt taaaggtcaa ccaacgccaa gcacaataac acagataaca
    47341 agagcaaaaa taagtgatgg gaaatctgta agagttattc tttcagaagg cgaaagcact
    47401 aaaacacaac aattttatct tataaatgga ttctttggag tcgctatgca agacggagaa
    47461 aaaggcgatg aagttacttt gcaaatagag caagctgaat acgaaacgga taatattgtt
    47521 acatcagaag cttttgaggc agggaaattg atttattggg ataatacagc taagaaattt
    47581 actactacat ctgcaagtaa taggctagtt ggtagagtaa cagatgggaa agacagtaat
    47641 aatgtaattt ggtttatatt attacctcaa caatagaaaa ggagtgataa atatatggca
    47701 tttaaagtaa ttagtcagga aaatttgctg gaacaaaaaa gaaaagaaac tttacaagaa
    47761 gatataccat ttatagtaaa tggtgaaatg gaatatgtaa caaagaaaat atcaaatgga
    47821 gaaatggaaa ccttggagtt aaataagcca cttggtgaaa tgatgacttt tagctcgact
    47881 tcaaatttaa aagagttatt aagaaaagtt gtattagatg ttgaactagg cagagagcaa
    47941 gtacaactat tatataaacc aatctatgac agtatagcag attctaattt accacaagtt
    48001 atggatgcta agtgggcttt acaaggtaac tgtgtattcc tagagcatat agaaggtgaa
    48061 gaaattaaat tcggtacaat aaatgcagaa aatggtccag ttgcaaggat acaaacttat
    48121 gcaactggtt ttgagtatac aaaagaaatg aaggatttta accaaacatt tagtgttgaa
    48181 atattaaata aatcaattgg tgagagttac aatgccttgt taaaccacat acatctaagc
    48241 ccaataataa attttaatta taaagcttct aataagacag cttttaaagg tgaaactaat
    48301 gacccaatat ggctaggaat ttggagaaca ttaacacaag cacaaaaaga tacagttata
    48361 gcaaaaagac aaggtaatat attaatggct tctagtgctg accaaattga aatagaaatg
    48421 gcgttaaatg gaggacattt attaaacgga agcatgtatc catctataaa aaatatatca
    48481 acagtaattt attatgatgg gtgggaggtt actgttggta aaaaaacata ttcttacaaa
    48541 ggtgttacac caggcaaagg atatttgata agacctaagc gaggatttaa agagttaata
    48601 aagagagatt taacaacaga ggttggaaat gctgatttaa gtaagttagt agaaaatcaa
    48661 attgtaggtc attgttatag aggtgctttt gcagcagtag aagaaaatgt acaagaaata
    48721 agttttagat aaaacactca taagagtgtt atttttatga ggtgataata tatgacacca
    48781 actagtaatt taatagaaaa attaagacta ttattaaatg ataaagataa aaaatcattt
    48841 acagatgaag aattaaactt gtttttagaa gaagcagact gtatttactg tgcagcttct
    48901 caaggatggg tattaaaatc tttacaatat gaaaatacag taggggaaat gtatgagtat
    48961 aaagtgggtc aagaaacata taaaagctct agtataaagg acctagtatc tgtagcttat
    49021 caaaatgcag agaaattcaa ggatatgtgt actaacaaaa aagaaaaggg aagttttatg
    49081 ttaggaatta gcacagaatt tgaaatatga taaatattga tagaagaaga aaagacataa
    49141 taagaactat taatatgaac cctaccaata ttactataac taatattaaa aaaactgaaa
    49201 tagatggagc ttttgaagaa actgaaacag agataaaatg tgttgttaga atatttaatg
    49261 aaaagacagc agagaaacaa atatcaagtg aaaagcaagg tacttttagt tctattagaa
    49321 catatggaat gttagtaagt gatgatgttg tcttagatgt taacagtaga gattctttgg
    49381 agtttgagtg catatatggg agaatgaaaa tagttaatgt atatcctcaa attgtaaaag
    49441 gagaactttg tgggtatcaa tgttcacttg aaaggattga ttaaaatgag tgctttcaca
    49501 aatgcaataa atgatataaa tagaaaaaaa gcaggtatgt ttgtactttg tatgagtgca
    49561 agtgcaatgc tagaaggtga agctaaagca aatgcaagtt ggacagacag aacatcacat
    49621 gcaagacaaa gtttaaatgc taaaactctt ggaggaggaa ataatttcat tattagatta
    49681 tcgcatggtg cagaatatgg aggaatactt gaagaaggtt caaaaccaca tgttattact
    49741 ccaaaatcag ctcaagcttt atactggaga ggtgcttcac atcctgtaaa atcagttcaa
    49801 catcctggta caaaagcaat gcctattata aaaccaacta ttgataaaaa tataggcaaa
    49861 ataggtaata tgatttttag atattggagt gattaaaatt gaaatatact ttagctaata
    49921 ttagaccttt gaataatttt ttagatttta atttagaaag ttttgaaata ctaacaaaaa
    49981 aaatgccaat cgatatatta aagccaaaag tagaacttat tagccttgat tatggtgaag
    50041 taaaattaat aaaaaaatat actgactgta tttgattatt tggagcaaat aaatgagagc
    50101 aggaataaga aaagcgttaa tagataatat aaaagaatta aaaggttgtt atgaacctaa
    50161 tgtaccaaac aaagatacta aaaagcctta tatggtagtt gtacaagggc aagacaatga
    50221 caacggagaa acaataggct ttgaaagaag tatagaaata tggatttatg aaggcagaac
    50281 aacattcaag aaattagata aattaactaa acaagttgtt gaagtcttag atatgaatac
    50341 tatagttgat gaatctgaaa acgaagcttt tacttgcatt tataaaggta caagtgaaaa
    50401 tgatattgtt gttgaggaat gggatgctat agcaagaggt ataaggttta gtgtaatagc
    50461 tttagaagat aaagaagata caactaatga taggtgggtt gaagctttat ctaagtatac
    50521 aaaagattta ttagaaattg agagttataa ggaaaattgg aagaaaaact ttatagctcc
    50581 atgcgcatta tggcgaacta caaatgttga aaacaaaaga ataaattatc atttgattga
    50641 gattaccaaa actatgaaat gtcatgttgt aagtaaaaat aaggatgaaa tagttaagtt
    50701 tcttgaagca ttagaaacaa gtttaataat agataaaaga gtaagactta gagaggataa
    50761 gaatatgtat ttaactcttg ttagcgtagt tgaggatagg gaatcagaca tgtttacaac
    50821 aggacaatta acagttgtgt tcaaaatgat aggtaagata aaaagagaag gtcctattat
    50881 ggataaaatt tatagtaatg gaaatttaaa ataggaggtg taagggttgg ctgaaacaat
    50941 taataaaaag actaatgtaa gtaagcagga agaaaaatat ttgaaaaatg atttcttaaa
    51001 aaatagtgaa gcacttggct acgaaaaaat ggtagttgca ggtgctttat ttaattgtaa
    51061 gaaagaagaa cttacaaaat cagagtttga gaaattaata aaagattttt tagaaagaga
    51121 ggtgaagtaa aatggcaact ggtacatgga atgaaaaaga aaaaaaggag ataccgggct
    51181 tttataacag attcaaaaca caagcagaaa agtctgcaaa cacaggatta aagggtagat
    51241 tagcaatacc agttaaggct aattggggag aagttggcaa ggttgtaaca ataaaaaatg
    51301 acttgagaca gcttaaaact ttgtttggtg atgatatgaa ctattcagcg tataagttag
    51361 gtaaattagc tttattagga aatgtaaaag agctgttatt atataggctt gtagatggaa
    51421 aacaaaagaa gggtacatta acactaaaag atactacaga aaatagtgca aaagatgtaa
    51481 ttaagttaga aactaagtat ccaacagcta gaaactttaa tgtaacaata aaatccaatt
    51541 tagtagattc agataaaaag gactttatat tctttgaaaa tactaaacag ttatttagtt
    51601 caagtattaa aggcactata gatgaaatag tactagaaat aaactcaaat ttagataatg
    51661 agtatgtaat tgcaactaaa gtagctgata gcgatacaat tctagcaaat gtagtaaatc
    51721 aagctttaga gggtgggaat gatggttgca catctattac taatgagtct tatctaaaag
    51781 cactagaaga atttgaaaga tatagttttg actcttttgt acttgatggt gtggctgagg
    51841 aagcattgca ggaaactaca aaagcttggg tagctaagaa taaggagcta ggaaaagata
    51901 tattattatt tcttggtgga aaagcagagg ataatataaa acaaattaat gataaatcaa
    51961 aaagttttaa tgatgaaaat atagttaatg ttgggagttc agcttattat gagggaataa
    52021 aatatacacc tagtgaagta gctgtttata ttgctgctct ttctgtaagt aaaggtataa
    52081 caggaagtat atgtaatgct aagactatat ttgaagaagt agaaccaaga ttaagccaaa
    52141 gtgaagtaaa agagtgtttg aaatcaggta cactaatact tgattttgat gatggagacg
    52201 taattatagt tgatgatgta aacacattta agaagtatgt agatgataag aatgaagcta
    52261 taggatatat ctctaatatt atgtttatta atactataaa taaagatact tcattgaagc
    52321 gaaaggaatt tgtaggtaag atatttaatg attcaacagg gcagacaact gttatatgtg
    52381 cattaaagaa atattttgaa gaattaatgg gtcaaggcat tatatcagaa tttaatgttg
    52441 atatagatac agagcttcaa gcaactgcta aagcagatga gttttattgg aaatgggatg
    52501 ctgtcaaggt tgatgtgatg aagaaaatct ttggaactgg atatttagga taaaggaggt
    52561 tataaagtat gggaaaatat gatgaaaata ttatagatgc tgcaaatgtt gcagatggct
    52621 cgaatgctaa aataatagtt gatgggaaag aagaaggata tggaacagag tttacagctg
    52681 aggttgaaaa tgataagaaa acctttagag tgattggttg caaatgggag cttaacaagg
    52741 catctactca aaaaggtact ttttctttaa ctgtacttaa aacaacatct gaatggatcg
    52801 aaagaggatt tgataaattt gaattaatat ctgaaataga aaatcctgga ttagttggat
    52861 atgaaagaat tagatataaa aattgtatgg tagataaaat acaactagca agtataaaag
    52921 ctgatgaaaa tatagaaata caaatagatg gtacttttga gggttatgag ctagtggata
    52981 aaatagcata ataaataaat ttaagctaca tgtaattaat tttatatgta gcttttcaaa
    53041 taaaactata aaaatggagg aagttaaaaa tggcaaactt agataaagaa tttttaaatg
    53101 aaggaataga agaagaaaga gaacttacta aagaggaaat agcaaagcaa caagaagata
    53161 atataattat gaaattgaca gaggatgcta tattacctga aaaaactatt tttgtaaaaa
    53221 gattagatat accacttaca cttagggctt taacagaaaa agagataagt gcgttgcaaa
    53281 aaaaatatac aaaagttact aaggtaagag gtagaaggga aagcaaacta atggaagatg
    53341 aatttaatat agctctaata gaaaaagcta caatagttcc taatttttgc gatgcaagac
    53401 ttcttaattc tatgaatgta tctagtggtg ttgaatttat aagaagaaag ttcttagcag
    53461 gagaaatcgc attaattagt gatgaggtac tagaattgtc tggattttat gaagaattaa
    53521 gtgatgatga tataaaaaac taataaagag aggtgggaag attactattt tatacaacgc
    53581 atatgttaaa catagtattc ttccagagga ctttttaaaa agagagaaaa cacctcaaca
    53641 gcttcttaga gtttttactc aacatgaaat agaacaagaa aataaagcta tgaaaaataa
    53701 ataaaattta aactaaaagt gaggtgagag aaatagctaa aaaagaaatg tatcacattg
    53761 atgttgtcat tgatgttaca ggagatgaac aaactaaaaa taaattaagt gctatggaaa
    53821 gatacacgaa acagacagaa aagagaatga gagcactaaa taggataaaa gctaatccag
    53881 ttatacaagc tcaagataaa acatctagtg ttgtaaatag aattagcaac aacttaaaaa
    53941 gagtgggtag aactatatct acaaccataa acgcaaaaga tagagcatct agcgttgtaa
    54001 atagagttaa aaacaaagta aatagcttac ttacaagtcg acaaagagaa gttttattaa
    54061 aggctagaga caaagctagt caagttgtag ataaagtaaa agctaaggta caaaatttga
    54121 ctgcggctac aataattagc ttgaatatga aagctgaccc agcactaaga gttatttctc
    54181 aaactagaag taagttagga gaactcaaaa acaacacaat aataaatatt aaagcaaaag
    54241 gtgaagaagc attaaatact atttctcgta ctaagagtaa attacaagag ttttctaata
    54301 ggacttatca agcaattgta aaattaaaag atgaagctag tccaactttg agtgggttag
    54361 atggtaagat aagttctttt ataagtagta ctattagtaa gtttacacaa ttagcagtaa
    54421 cagccacagc attaattggt ggtgttggag taggaagtgc tataaaagga tttgcagact
    54481 ttgaacaagc aatgaaaaac gcacaagctg tatcaagtgc aaattcaaag gaaatggcag
    54541 aaatgactgc aatggcaagg gaaatgggtc gtacaactag ctttacagct aaagatgcag
    54601 ggaatgctat gtattttatg gggatggctg gatggaaaag caaagaaatg attgctggtc
    54661 tacctggtat attaaatttg gcagcaacag gtcagacaga tttagcacta acagcagata
    54721 ttgtgactga tggtttaact gctttagggc taactgcaaa ggatacagga atgtttgttg
    54781 atgttatggc agcaacagtt acaaactcta acacagacat agaaagaatg ggtgaaactt
    54841 ttaagtatat gggaagtgtt ggaggagcat taggtgtttc tatgaaagat ttgagtttag
    54901 caactggctt aatggctagt gcaagcgtta aaggtagcat ggcaggtact gcacttagag
    54961 gtggtttagt tagattaata aaacccccag ctgaggcaca gaaagctatg aataaatatg
    55021 gaatagaaat aaagaaaaca aaagatggaa atttagattt agctagtaca atcgttgacc
    55081 ttagagaaaa attaggcgga cttgaaggag tacaaaaaag tgctgcaata agtagcatat
    55141 ttgggcgaac agccatggcc ggttgggcgg ctgtagtaaa cgcaagtgaa aaagatttta
    55201 aaaaattaac aacagctata aatgaaagtg aaggagaagc taagagaatt gctgatatga
    55261 aactagatac cctgtcagga caatttgaaa ttttaaaaag tgctattgat gatgtaagaa
    55321 tatcagtagg tcaaagactt ggacctatga cacgaagttt tgttgaacag ttaacaaaag
    55381 atatgcctaa aataggggat gccatcgtta gttttgtaag tgattttata aatgattttg
    55441 ataaaattaa aagtattatg caaaatgtca tttcagtaat atctggaata gtatctgcat
    55501 ttattgcttt caaagcttta aagtttattt cttttctaat tcctatatta agcgatatag
    55561 gatttgcaat agctgctttt gcaggtggtg cggcaacgct aggagaagct ttattgtttg
    55621 cactaggtgg acctgttggt gctgttatag caggagtagt attactagca acagcattta
    55681 cattagctta tcaaaaatca gatgctttta gaaaaattgt caaaaatgta ggaaaatcaa
    55741 ttaaaaattt tttacaagaa gcaataatag caatttcacc ttttgtaaat gtgtttggta
    55801 acaaattaaa agaattaggg aaagctgtaa ttccattgtt aaaagtattt ggggattttg
    55861 catcaacgct aatgagtaaa atcggaccta taattttgtt tttatcaagt aatgttttag
    55921 ctggctttat attaactttt gtagctgctg tagaagctgt taaatctgct gtagtcgcga
    55981 taacaggtgt attgcaaggt ttaacatcaa ttataaaagg agtttttgat attgttggag
    56041 gaataataag tggtgatggg aaacaaataa taaatggctt aaaatctgta tttgaaggag
    56101 gaataaaaat tgtttcttct gtttggaaag gattagtaga tattgtaact tctcctattc
    56161 aagctgttgt agatgttcta gacgaaaaat tcggaaaaaa agtagaggga ataaagaaaa
    56221 aatggaatga attaaaagac ttcttaaaaa atcctactaa agcagctcca aaagttcaac
    56281 ctgtcaattt atctggagag aaagcatcaa acgagttaca agcttcatca aacggagcaa
    56341 aagcatatat aagttcgtta ggtcaaaaaa taggtgaagg tattggaaaa attaaagata
    56401 aatttggaga actcaaaata tctgcaacag aagtatttaa taatatagta tctttcgtag
    56461 gaggcaaagc aaccgaatta aaagataaac ttttagaagg cataaaacct gctatagata
    56521 catttaaaca atcattaagt aatttaaaag aagtttttgg agattcttta gatagcataa
    56581 aagaagcttt tggaggttta aaaactgtat ttgatgaaaa tattaaaacg cctttcgaaa
    56641 atttaaaaca aaaagtttta gaaacaaaag aaagtttaaa accagttttt gataacttaa
    56701 aatctagctt tgcagaacta ggaaaagctc ttgaaccaat aaaagaagca tttagtggaa
    56761 taaaagattt cttttcaaat ttgtttaagc caattaaaga tgatggagca actaagacaa
    56821 ctaaaaccaa tatggatgag ttaaaacaat caacacaacg tgttggaaca tctttcaaag
    56881 agttaggaaa tgctttcaac caattaaaag aagcagcaaa accttttata gactatttaa
    56941 aacagataaa agattcttta acatctactc tgggagatat agggggagga ttactcaaag
    57001 gtgtagcaac ttctatagtt ttagttataa cttctgttat taatgcaatt gcatctatta
    57061 taaatgctgt agcaggtgct ataaaaggtg taattgatat aataaaagga atattcgaaa
    57121 tcataggtgg gataattagt ggtgatggtg aaaaaataaa acaaggattt tctgatgttt
    57181 tcaaaggaat tggggaagta gtcaaatcat tgtgggaagg tataaaagga gttttaggag
    57241 caccacttaa agcagttgta aattttattg ataatggatt ttcagaaaaa gtagggcaag
    57301 taaaacaatg gtggtctgat ttaaaaacta atgtaggcca aaaaataagc ggatttgtta
    57361 gttttgtaag caatggtttt caacaaaaag ttcaacaagt tggaatgtgg tggcaaggac
    57421 ttaaagtaaa tttatctggc aaaataagtg gatttgtaag tcttgtagaa aacggattta
    57481 aaagtaaagt ggattcaatt aaatcagcat gggatagttt aagaaaaaaa ttatcacaaa
    57541 aaataactgg ttttgtaagt atagtaaaaa ctggaataag taatgtattg gaccgttttg
    57601 ctgatggtgg agttgcaagt aaaccaagta tttgtggaga agcaggtcct gaaatggtta
    57661 ttcctctttc taatagtaag agaagtagag cattaagttt atatgaacaa gcaggacaga
    57721 tgcttggaac taaagcaagc aataatgtta ttccaatatc tcaaaaatta ggaactagtt
    57781 ttaattctgc aagtagtatc caaaatagta attctagtat tattaataat gttagacaat
    57841 ttcctaccaa acaagaagaa tttaataata cagaaaatag aatttatcaa gaagctcaac
    57901 cacaaaacat aatttctagt ggaagtaatg cgattaatgt tggtggaata tctataaata
    57961 ttcaaggtag caacaacaaa gaagaaatga tacaagaaat attgtctcaa gtggaaagtg
    58021 gattaagaga agcattagaa gacattggat aatgtcgaat tgttgttaaa aaaatcctcc
    58081 ttatagatgt tataatttaa ttataaatta catgaggggg atttgcatat tatgtgggga
    58141 agatttaaaa atatgagtat aatcttaaag gttttagttt tagtttgtgc tatagcaatt
    58201 tttccaataa ctttattagc attttctata gaatttgtag ttaaatcttt taaaagaaac
    58261 gaaaggttta aagttgtttt tggcgtattt ttagttttta ttacattttc atttgtatgt
    58321 atttggtatt tgttagaaga taatataaca actagcaata gtagtaataa aaaacaagaa
    58381 gaacatctaa aagaagagcc aggtaaaaat ctagcaacaa gagaagcaga agaagaaaca
    58441 aataagaaga aagaacaaga gaaacagaaa aatgaaggta cagaagctga aaaaaaagag
    58501 cgagataaaa ctgagaaaaa agaaaaagta gataaaaaat atcaagagaa gaataaagag
    58561 aaagcagaaa cgaaaaagca aacattaact agtgaagaat taaagaaaaa agttgattct
    58621 ataattccag cagagtataa aggaaattat tacacaaatg atgtattaga tacagatggt
    58681 agctatgtac ttagtttaca agttcaaaat gcaagttttg acaatgaaag cagttgtaag
    58741 gcatttacta aagacttaat taacaagttg aaagaattta gaatagactc agcagaagta
    58801 tattttgtag gttcaagtgg tcaaacaaca tatcaaatta atatagatga tttcttgaaa
    58861 gttcaagata atattaagag tgtagataat atggagtttt tctctttcaa agattttaaa
    58921 aattagatat ataagaaaaa gacgtttatt tattaggaat agatgtcttt tttattgtaa
    58981 aaaggaagtg ataatttggt aatagacata tacctaaaaa atgaaaaaga aaaaatagat
    59041 tttcattttc cagtaaatcc attcgatagt ttatctatta aaaaagaaaa aaggtttgaa
    59101 actgtagata tagtaaactt aggcgaattt gacattaaaa aagaaggaga gaagataaga
    59161 gaaatatcat ttaaaacatt tctgcctaac ttatatgacg cttcttattg cagatacagt
    59221 gagttaaaaa atccaatcga agtagtggca atgcttgaaa agtgggtaga ccaagctgaa
    59281 ccattacgat taatagtaac tggttttggc tacaatggat tagttacaat atctaatttt
    59341 agtaatactc aaacagcagg aagagaagaa gacagagata ttgagataac atttagaact
    59401 tacagagaac tgaagataga gacattaaag aaagaaacta aaagtaatac taaaacagat
    59461 ttaaaagaca atagacctaa taataaaacc actccaaaaa tatatactgt taagtcaagt
    59521 gatacattat ataagatagc taaaaatctt ttaggcaaag gttcgagatg gccagaaatt
    59581 tacaatatac ccgaaaacaa aaaagtcatt ggtaaaaatc cgaatgtgat taaaaaagga
    59641 caaaagttgg tgataccttc taaatgaaaa taatattaaa tggaaaatat gatattgcaa
    59701 attttaacga gggaataaca ttaagtgaag ctatagacgg agttgcatat aagatggatg
    59761 tatcattagt agaacctaaa caacttcaag atatatggat taaaaaaggt gataaaatag
    59821 ttctaattga cattgcatat gagagtaaaa aagaagaaac aatctttgat ggagtcatat
    59881 gggaaactag gagaagtgaa aagagtaaaa aactgacatt atcttgtaga gaaagaactg
    59941 tttacatgga agaatcagaa gaacaatatt cgtttaaaga aaatacagca acacaaagaa
    60001 ttgaatacta ctgcaaacaa tggaatatac cttactacaa tctagcgaat acttctgtaa
    60061 aacttgctaa agtaatacat aagacaaata tactagatat gattaaaaaa gacttaaaag
    60121 aaacagcgag taagggtgga gacttattta gagtaaggat ggataataaa ttaaaactat
    60181 ttaagcttgg tactaatgca aatgtatata aattagatag tatattagaa gatgcaaact
    60241 ttacaagtag ttttaatgat gcagtaacaa gtgtaaaagt tttaggaaag agtaaagatg
    60301 aaaatacaaa agcacctatc attggaacat ataaaaagga ctcagacaaa tatggaacac
    60361 tgcaaaagat taaacaagat gaaaagataa aaaatactaa agaagctaag aaagcagcag
    60421 aagcaatgtt caatagtgga gaggaaacaa taagtgtaga ttgtgcagta gatataaata
    60481 gaataagagc aggtgacaag gtaagtttaa aaagtaaaga atattatgtt atagatgtca
    60541 ctcatacact agattctaga ctgaaaatga agctcaatat agggacttta gaatatataa
    60601 ggaggaagtt ttataacaat gactgatgct agatttaatg gaattgctag aatattgaaa
    60661 gaaaatatga ataaaagtgt agcaaatagc acttttggaa tgggttgtga acttgcagaa
    60721 ataacaacaa atggattaaa agtaaatggt tataaagatg aaatacaaga ttatttagta
    60781 ttagagagtt taatattaaa agaggattat tttacttttt cagatgaagc tttaagtgga
    60841 gaatataggc ataagcataa aatagaaact acaaaagaat taaaaccctt ggctataggc
    60901 gataaggtgt tagtagcagt catgggagct gaatttgcag taattgggag ggttgtaaat
    60961 gccaaaccta tttccaatta atgagaaatt tgaaactgta gaattaaaaa ataatgatga
    61021 aaatgaattg gacctaaagg gttctttttt atttgatttt gaaaaaggtg aatttgttaa
    61081 aaatgcagat ggaacattaa aaaaatgcga taaagttcaa gcgtacaaac aatggtgtca
    61141 gaaagctata ttaacaccta ggcacaaaag gtcagcttat tctagtgtat atggaagtga
    61201 aataaaagaa ttaatcgcta gtaacttatc acaaaatgca aaagagcttg aaataactag
    61261 attaataaaa gaaactcttt tagtgcatcc ttacacaaaa gaagtaggag agtttagttt
    61321 taattggctg gagaatagca ggttagtaga gtatgaattt aatgtattaa caatagatga
    61381 tgaaaatata gtaattgatg gcaatataaa aaggtaggtg attatatgca aagagagcta
    61441 cctataccag tatttttaac agaagatgag gactctgtac atgaaaggat gttaagtaac
    61501 tttcaagatg tgagcacact agaaggggac tttatttatg atgcaacaag acctacagca
    61561 gagcagatag ccgaattaaa acaactagga ttacaaaata atttaaagat agcatttcct
    61621 cagacctctt atggaactta tttagagtgg cttggtgaat gtaaaggagt atttaaaaat
    61681 caaccaacta aggctactgg agttattaca tttacaggta tgcaaggaac tatcattaca
    61741 aaaggaacta tagtaactac tattgcaact gatgaaaaac agagcataga atttgagctt
    61801 cttgaaacta aaactatagg agaaaatgaa acagtagata ttaaagcaga atgtagagtt
    61861 gcaggaatta tagggaatgt gtctaaaggt agtgtagccg ttttgctagg ttctattaat
    61921 ggtattaaat cagttactaa taaagaagat ttcaaaggtg gaacagatat tgaagacgaa
    61981 gaacatttta gagaaagagt tcttgtagca gaacaagaag ataaacttag tggagctagt
    62041 tcagattata taagatgggc taaagaagta gatggagtgg gatatgctta tgtagttccc
    62101 gaatggaatg gagcagggac agtaaaagta ttaatactag ataaaaacag aaaagcagca
    62161 acacaagaat taatagataa ggtccaagaa tatatatatc cattgaatat atcagaagga
    62221 gaaaatagag atgggaaagc tcctatcggt gcattagtta cagttgtgac acctgacaca
    62281 ttacttatta atgtaaaagc tagttttata tttagtaatg gctttagtga agaaactgta
    62341 ttaaacaatc taaaaactaa gatagataaa tatttagata agattgattt aggggggaca
    62401 gtctcataca atgctataca ggcgatagta ggctctatga tgctgacaga tgaaggtata
    62461 gaagactttt ctaatcttac tataaatgat gtaaaagaaa atataaaatt gcaagaccaa
    62521 gtggtcggaa taggggaaat agttaacgag gtggttggat gatagcttct aaaaaaggta
    62581 aagaaatgct tcttacatta tctcctatct atgaacaatc tatcataatg caaagcttat
    62641 atgaagctat aggaagcgaa tttgataatc tagaattatt aaataaagaa atagagttac
    62701 aattattccc tcagagtgcg acatggggac ttgaattttg ggaaaataga gtgggtttat
    62761 ccactaatat agatgaagat atagaagcta gaagaagaaa ggtcattgct aagcttcaaa
    62821 gtaaatatat tatgacacct aaaagaatgg ctatgatact ccaatcttat acaggtgcaa
    62881 acataaaaat aaatgaaaat atatctccat atacttttgg tgttgaatta accagtaccc
    62941 aaggttttcc taaagattta gaagatttat ataagagagt aaatgttata aaaccttctc
    63001 atttagctgt aagttataag ttagtttctt tattgaaaag taaaacctat tttgcacaaa
    63061 cggcaattat gagcgaagaa ataactgtat atccgtacac aagcaaagaa gtaaaagcaa
    63121 gtgttaaagc caagtttgca ctagctcata acatgagctc agaaacatta acagtatatc
    63181 caagatagga ggtggcataa atggctgatg aacaatttta cacaatacta acaaacatag
    63241 gtaaagctaa gattgctaat gcaggaatgt taggtaagtc agtaatttta gagaagattc
    63301 aagcaggtga tggtggagga aactactata atccaacaga agaccaaaca gcattaaaaa
    63361 ataaagtttg ggaagggaat ataaatgctt ttgataatga tgaaaataat cctaactgga
    63421 ttattgcaac agcatgtatc cctggttcga taggtggatt tacagttaga gaaatgggtc
    63481 ttatagataa tgaaggagat atgattgcag tttgtaaaag ccctgaaacc tacaagccaa
    63541 aagttgataa tggagctatg aaagatttgt atttgaaatt tatcatagaa gtatctaatg
    63601 tagagaaagt gacattagtt gttgacccta cagctatttt tctaactaaa aaagatgaag
    63661 aaaaaatatt aacaaatatt aataaactag acactaaaat agatacaacc aaaacagaat
    63721 taacaagcaa catagaaact actaaaacag agctaaacac tagaattgac acagaaaatg
    63781 agaaacaaaa tattaaaatt gaccaattaa tcgcaggtgg ttcaaatgtg gcatctactc
    63841 aaataataac aattgatgat tgggttgagg atgcagaaaa tggattcaaa gcaactgtaa
    63901 cacatagttt attaacacag agaatagttg taaatattat agatgctact acaaaagaaa
    63961 atgcagttac aaactttaaa attatagatg ataattctat agaagttaga agtgaaacaa
    64021 ggtcagaatt aaacgtttat gtgataaatg gaaatgcaga aactcatttt attaatgcaa
    64081 ctgtagatga taacagagta tctgaaatga ctacttattc gtctaagaaa atcgaagata
    64141 gatttgttaa tctagaagaa aaggtaaatg gtggtttatc taatattgca actagtgtaa
    64201 atgagttaat aacttattgt tagagaggag agtgagaaaa tgcagactga atggaatttt
    64261 ggttataatg gttcgccaca aagtgttata ttgaaacctg gcaaatataa atttgaatgc
    64321 tggggttctt ctggaggtat caacaattct tcttggcata ctgatgctaa aggcggatat
    64381 tctaaaggtg aaattacatt aaaaaaacaa actacattat atgtttacgt cggcgaaagt
    64441 ggttttgctt cttcatctac gagtaataac actaaaagtg gttttaatgg cggtggtaaa
    64501 ggttatttaa atcaacaggt tatgggtact tattattcta tgtacggtgg tggtgctact
    64561 gatataaggc tcgttggtgg tgcttgggat aatgagcaag gtttgctatc tcgtataatt
    64621 gtcgcaggtg gtggcggtgg ttcatattct ccttatactg gtggtgcagg aggagaatta
    64681 gcaggaggta ctgggtatag tgctaacgac agacatcgtc ccggcggtac tcaatatcaa
    64741 ggtggtattg gtcgtgtaag cacagaaaac ggaagttttg gaaaagggtg ttctgctaaa
    64801 gattcaactg gcgaaggcgg tggaggtggc tggtttggtg gtgcaggaat gaatggtgtg
    64861 ggagcaggtg gaggtggaag tggctacata ttaactaaag atagttataa gcctactggc
    64921 tacacaccaa catctgaata ttattttgat aatgttgtta tggaatctgg tggaaatact
    64981 gctggtgctt atggttatgc cctaataaca ttactacaag cattaccttt tttaaccgta
    65041 tcctcttata actcaactac agcaacattc aaagccgacc acacagaccc agcattgtta
    65101 actaaaatag aatactttat agatgatgta ttaaaagaaa ctatcacaac agatttaact
    65161 cttgaaaaaa caattaacta tacattagaa gataatgcac tacacacact taagatagtt
    65221 gttacagaca gtaataatgc tacagcagaa aaagtgttaa gtataagtaa gaatataatg
    65281 ccactgcccg aaaatgtaaa tttaaatgat atatcaacaa aactgacaga agttaatgca
    65341 ggatttaaaa ctggtaaaac aagtattata aatactttag cattaaagaa tatagaagca
    65401 agtttgaata atacacttgt ggagttatca gagaaaatta aaacttcttt tgatagttct
    65461 gacgctagtg tacaagattt gatgaatcag ttaacgcaat ctaataatac tataacacag
    65521 ttaaatacta agtatcaata ttttagtggt gttaccactc tcattggcaa tagtatttgt
    65581 atagctaatt tttatggaaa ggcatctggt atgtatcctg gctattggat tagggttgga
    65641 ggttttaaat ctgttcctaa tatttttatt gctgaatgcg aatatattta tgatggtaaa
    65701 ttttataaac atcttatttt tgcttcttgc ggtgttttta ctaaagattt tactattcgt
    65761 ttatgtttta gtcgtgaaat agatgttaat acctttagcg ttaaaggtga tattttcaat
    65821 attgaagagc aggatgtttg gtataatact aatcttggtc ttaatctgcc tgcatataac
    65881 actaatatac cagttaattt taattggtgt gctataaaat ttaaataaat gaggtgataa
    65941 aatgaataga gcaaatagaa taatttacga ccaaacaggc aaaatacttt tacaaactgg
    66001 agaagcaaca ggggatatat tagaacatga tgaaataaca gaattgcatt gcattgacat
    66061 tgagtatgga agtatagatt atacaaaaaa tagaattaca ggtataaata tagaaacgaa
    66121 agaaccaatt ttggaagaaa taccaatatt cgtttcagaa gaagaaaaga gaatacaaga
    66181 gttagaaaac caattattac taaatgaaaa tgaaaaagta ggaggattat tataatgaat
    66241 ataaataatg ttgtagtaag aatattagca gagaggattt taagtagagg cttaaatcct
    66301 ttaaaaaatc gagaatttga attagatgac gtaactaaca cagagtatag aaaagcagta
    66361 gaggattata taattaaaca gagtggagta gtagaaggaa tagaaccaac agcttagtag
    66421 gttctttttt ttattgaaag aggtgattaa atgactttta aagagttagt taataaagtt
    66481 agaaatcttg tattagaagc agagaaagta actatagaag atacagagaa taattttaca
    66541 agtgataatg tagaagatgc tttaaaagag gtttttcagt ctggagttga tgctaaaaat
    66601 aatgtagtaa cagcattaaa ctccaagggc gcagaggtta ctacaagcga tacatgggaa
    66661 gaaataaaga ataaaataaa tgatagtaaa tgtagtttcg ctttgtttga aactacattt
    66721 actaataaaa ggtttatcat aaataaaata tttgatgaag acgtaaaaga gatgacattg
    66781 tttcataacg atatagattg ttactttata gtagctaagt tttatatata taaaatggat
    66841 tctaatttca atttaattta taaaaataga cttacttata acccagatgg tgcctatata
    66901 gatgagaatt atatttatat aggagatgtg tataatctat ctaaatatga caaagaaagt
    66961 gggaatcttg tttcttcacg tactaatatt ggttgtcttt atatgtgtgg agatgaaaat
    67021 tatttatatg cagttgtaac ttctgggctt ggaggagtaa gaccatctga aaagtttatc
    67081 aaaatagata agttaaattt gtcaaccatt atagagaatg gagatggaac agataatagc
    67141 acatatgagt ttagatacca cgaaaaattt gtaatgaact caaataacat ttattttatg
    67201 aaagcaaaac ataaaaaaaa tagttataat gattattacc aatatttatg taaaatgaat
    67261 ccaaatacac tgaatataga tacacaatta acaatttata ataatgtgcc ctataaagac
    67321 tatgtaaaag gatttgtttt tataggtgac aagatttatt tgactaaaca aagaaatata
    67381 gagtcagctt tgagtaaaac tttatctgtt gttgataaag atttaaattt aactgaatta
    67441 ggagctgata catattctcc aaatagggat ttaattacag atggaacata cctttattca
    67501 gtttctgcat ggagtagtcc aagcagattt gatttagaaa aaataaatgt atcagatttt
    67561 aaaaaaataa ctgagtattc ttgtcattca gatttaaaat cttttgtaac tttatgtaat
    67621 aacaaaatat gctttactag tagttcaggt atttgtttag ctatattagt atctaatatt
    67681 ttaattcaaa aagaaggaga ggaactttaa tgatttattt aggaaattta atggacacag
    67741 aagaacaaaa tataaaatat gttggaatga tacactataa accaagtata ttaggtgaag
    67801 aagatttaaa aagtggaatt ttagttgatg aattgccagt acaacaatat atagaaaata
    67861 aagaagcaaa gttatttata aatatagata ctaaagaagt attttacaga tatacagata
    67921 ttaaaagtag tatggaagat aaagtaaatt ctacagaaca aacaatagca gatttaacat
    67981 ttcaattaat gagtaatggg gtgatatagt atgaattggt ataagataat agcagatttt
    68041 tataagaatg gcaactggac taaagagcaa gttaaaacag cagtagaaaa gaataagata
    68101 acagcaagtg aatataaaga aataacagga gaggactata tagtatagtc ttttttaatt
    68161 caaaaattag gaggttttca tgaatgaaga acttttcgaa gcagatttaa aaagacatga
    68221 aacaagaata aataaacatg gagaagaaat agacgaatta aaaatagcaa atatagagtc
    68281 taaagcagag ttaaaagcat tgtgtgagaa tctaaactca cttacaagta tgctcaaatg
    68341 gctaattggt acaatgatta caacacttgt agggttcttt atatttgcag ttcaaagagg
    68401 aatattttaa ttaattagga ggataagaga tggataattt aataagtttt ataccagagc
    68461 agttgctaat tttagtagct gctctctcta ttataggtaa gggctgtaag aagtataagc
    68521 aactagataa caaatatatt ccagtagtgt tattaatact tggtatagga ttttctattt
    68581 ggatgttagg actaagtcct gttgcagtct tacaaggcgt gatttgttgg ggtatatcaa
    68641 taggtataaa ccaaacttac aaacagttga aggaggaaaa taaataatga aaatatgtat
    68701 aacagtagga cacagtattt taaaaagtgg agcatgtact tctgctgatg gagtagttaa
    68761 cgagtatcaa tacaacaaat ctcttgcacc agtattagca gatacattta gaaaagaagg
    68821 gcataaggca gatgtaataa tatgcccaga aaagcagttt aaaactaaga atgaagaaaa
    68881 gtcttataaa atacctagag ttaatagtgg aggatatgat ttacttatag agttacattt
    68941 aaatgcaagt aacggtcaag gtaaaggttc agaagttcta tattatagta ataaaggctt
    69001 agagtatgca actagaatat gtgataaact aggtacagta tttaaaaata gaggagctaa
    69061 attagataaa agtttatata ttttaaacag ttctaaaccc actgcaatac taattgaaag
    69121 tttcttttgt gataacaagg aggattatga gaaggctaag aaacttggat atgaaggtat
    69181 ggctaagtta attgtagaag gtgtattaaa taagagtatt gaaagtaatg aggtgaagca
    69241 aatgtataaa cacacaatag tgtacagtgg tgatgataga gtatcagcag atattttagg
    69301 attatattat aagagagaaa aagaaagtta cttagtaaca gatataaaag actataaacc
    69361 acatagaaca caaaatctat atgtaatcgg tggagtaact tgtaataaaa tgaaggaaat
    69421 gagtaagact acaggagaaa aatttactca actatatggt aatgatgtgt ggtcaacatt
    69481 ggataaagct atagaatttg taaaagaaaa attgtagagt taatgatgaa tagctaatga
    69541 tagactatat ttgtatagtt tatcattagt ttatgcaatc aaaattatta tttttcagaa
    69601 ttgaaatttt catgctcttt acttactaga taatcattaa agtcacagaa ttttaaatta
    69661 taataacttt cgtaactatt atcataatga actttttcat tattttcaat agaatttaaa
    69721 taactatggt tgttaatatt tgcatttttt atatttaagt atgtaaacat gtagatttta
    69781 taatatttat aaatattatg atataataag gtaagtaaag tttattttta tagggggata
    69841 ttaatgagaa agattgagat ttttaacaaa ctaacaggaa ttagttgtcc aatatttgga
    69901 gtgtcatggg atccaccaga aagtgaaaga aaaattgcta gaagaattat agtttttctt
    69961 gaaccaaaaa gagttctata ttctccatat gaatatgaga ctattgaacc agttgtgaat
    70021 tctgtaatag aaataaaaaa ttatttaaca tcagagttaa tgaatgttaa tgaaaaatct
    70081 gaattacaag gatatattag agctatgaga aattcttgta ataagttttt gagtaaatgc
    70141 aaggatgata ataattttag agtgcaagct tgttgtgctg gaaatatatc taattggatt
    70201 tttacttctg caataggaga aatgagaggg aattttggca taatgatagg tcaaatagta
    70261 tctgcttatg gaataagtat tgaagacgac cttgcaaaca ttataccaga ataagacaaa
    70321 ttatatgtga tatttatttt aatcaaaaga ttttaaatta ataatagtat aaattgtaga
    70381 gtattatatt ttttacattg aatataaaat aacctgtgat aataaaacga acgaaaatta
    70441 tcatactaaa acataagaca tgttataatt atattacata tttcataaat atacatttaa
    70501 agcattcctt ttatacgagt gcttattttt ttgaaattca ttaatgtata aactatcaag
    70561 aacattactc aacacacctt aaaatcgatt taaattcttt ttcatacaca aagttatatg
    70621 atataataaa aaagtaaata tgtaacccca acacatcttt actaagtcaa acattattat
    70681 atagagcatt cttcattatg gagagtgctt tttcatttct ttgaataacc atgttgatta
    70741 tttataatat tttcatttaa tttatcttta tctatcaaat ttaatgcaca attaatacaa
    70801 atgttagttt tcatatgact tttcttatga aaagtaatat acttattatc atctttgttt
    70861 attcctttat tacagtaatc acataatata gtcttagtca tatttttatt cctttcattt
    70921 tatattttcc ataattaagt ttaacatatt tagtatatac ctatgtatat atatttaaaa
    70981 caatgttttt tattgcaata tagaatatat tgtataaata aaaaaatatg gagaatggat
    71041 atttgataat tgtaaaatta tgttataatt aaaatgcaag aatatatctt gcaagaggct
    71101 acaatctaag ggcgaaagtt ttcggaaatc accttcgaac gaaagggggt gagtatatga
    71161 aaacacttat gtttatactt gttatagcgt attacattac tattgtaata aaatctatta
    71221 caacaatagt aaagtctata acaagattat tagattctat aagtagatta aaagaatctt
    71281 tacataaact aagaaatcgt cctgacggca atcaagacga tttcaatgaa taaatcatta
    71341 cttaaattat tttgaatttg aaacttcgct ctaggctaat agattgtagt ttcttttttt
    71401 gtttttgata cgaatttaca tctttattat atcgcatttt aagaaaaaat aaaactatga
    71461 atattataaa tctattttaa ttaatttttt atcatatcat tatttaaaag tagataaaac
    71521 taaaaagggt tctctag
//
LOCUS       DAEQCW010000008        67187 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.008, whole genome shotgun sequence.
ACCESSION   DAEQCW010000008 DAEQCW010000000
VERSION     DAEQCW010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 67187)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 67187)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..67187
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.008"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            173..1501
                     /locus_tag="KRO40_000563"
     CDS             173..1501
                     /locus_tag="KRO40_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2091402.1"
                     /translation="MGSNELKKTLGVSAALSTVVGSVIGAGVFFKPQAVYTLTGGAPG
                     LGILAWLIAGIITITAGLTAAEVSVAIPKTGGMMVYIKEIYGEKLGFLTGWMQIVLFY
                     PGMMAALGVIFGEQASALIGSPSLLLPIAIGIIVIVAGLNMLGSKTGGVIQTVSTICK
                     LIPLILIMVVGFIKGGGNNPILTPMVGEGLSLGSVLGQVLIAILFAFDGWMNVGTLAG
                     EMKNPGKDLPKAIIGGLSVVMAVYFIINLAYLWVLPANELANYASPASAVAEVIFGSM
                     GGKIISVGILISVFGALNGFLLTGSRVAYTLATDKTLPKYGIFSKLNSAQVPANAIAL
                     VSVIASIYALSGQFNLLTDLAVFATWIFYVLTFIGVMKLRKTHPNIPREYKVPLYPIV
                     PIIAIASGIFVVVNQLCFAGMKTTMISIGGLVITAIGLPVYAYMTRGVKR"
     gene            2254..3087
                     /locus_tag="KRO40_000564"
     CDS             2254..3087
                     /locus_tag="KRO40_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBH2091403.1"
                     /translation="MRNKKKKINRKKLYLLLSAIVVCLAFIVVGVRVSSLNMKENEIS
                     RNAKLSSSTITDIVSNTSIEVSKGPSKSSGKIAYITIDDGPSKFTDEMIKTLNKYNVK
                     ATFFMIDGNMKEYPQQVKNIIKNGNTAGFHSVSHDIHKLYVTSTSAKEEFDTNDQTFY
                     KITGKHSKVIRIPYGSKPYTPQASYQALVDAGYKIWDWDLDTEDWRSNSSQIVQNVKN
                     HIKNRKGEDKDQLVVLMHEKKQSAEALDSVLKFLSDEGYEFAPVDQNQIPKNYWLRNL
                     E"
     gene            3180..4112
                     /locus_tag="KRO40_000565"
     CDS             3180..4112
                     /locus_tag="KRO40_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH2091404.1"
                     /translation="MVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYIN
                     GQSLDELEKTLDKKGRNKLENVIISFMVDNELLYQEAKDKGLTPSKSEVDSKYQELED
                     KMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDMEAYYTSHK
                     KDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYS
                     DDKATGKNGGQLGYFTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQ
                     KSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR"
     gene            4164..4646
                     /locus_tag="KRO40_000566"
     CDS             4164..4646
                     /locus_tag="KRO40_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2091405.1"
                     /translation="MFKSLKRTKVEKYIIDNKDSFYRIAYSYTKNEEDALDVVQEAMY
                     KALYSVENIKEVNYIKTWFYKILVRTSIDFIRKNRKYNNMTDIDLIDETGEYDKYTDL
                     DLRRALEELPIEYKSIIILRFFEDLKIEEVAIILDENVNTVKTRLYTALKKLKLKIEE
                     "
     gene            4658..5527
                     /locus_tag="KRO40_000567"
     CDS             4658..5527
                     /locus_tag="KRO40_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH2091406.1"
                     /translation="MTSKERLNKLKDEYHKIPIPKKLDTIINHEKIENIYREKNKKVN
                     RLRFKVAIAFACIFTVLVNISPVFADNFSKIPVIGAIVEVITIKNYSLKSENYEAEID
                     IPKIRGLKDKNLEQRLNSSFMEDGKRLYHQFQERMEKIQSSKNKGYKSLSLSYSVKNN
                     SKKFLSIEMTKNEIEASSYVSKVHYTIDKKRQIVLTLPMLFKDDKYIKVISDNIKEQM
                     REQMKKDSTKSYFIDQKKDLPVEDFKTINKYQDFYFNKNEDLVICFDEYEVAPGYMGA
                     VEFVIPYKVIKDL"
     gene            5570..6325
                     /locus_tag="KRO40_000568"
     CDS             5570..6325
                     /locus_tag="KRO40_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH2091407.1"
                     /translation="MTTYKKLKKSIFKIAIFSICLLVSLVDTNPIFAGSSFNETSNSD
                     TIKVLNTKSINFKQDNYEVNVSIPKIKGLKDKTLENKLNNEFLQDGKKIYSEFQNKMK
                     KEDNKGHRYLNVIHNVKNNSKDFLSIEMTKEEIEASSSITKKHYTVDKNRGILLNLPI
                     FFKDSRYIRAISDNIKEQMRNQIKKDDTKSYFIDQDKDSPVKDFESINKYQDFYFNKN
                     GNLVISFDEYEVAPGYMGAVEFVIPNKVIKRLR"
     gene            6367..7188
                     /locus_tag="KRO40_000569"
     CDS             6367..7188
                     /locus_tag="KRO40_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XdhC family protein"
                     /protein_id="HBH2091408.1"
                     /translation="MNIYEQAIRLIENNEDFAFATITSHSGSTPRETGAMMIVKNDST
                     IFGSVGGGSVEAECIKHAINVIKNRESMLYKFTLNKSDVAKLGMICGGTGEIQIDFID
                     SKLKSNIEKFNKRLKENTSKAYIFGAGHISRDVAVILSLLEFRTVVIDDREEFANHER
                     FPESEVVVLDSFENIPDFPTDKNSYIIILTRGHLYDSSALEWALKREAGYIGMIGSRT
                     KIGLTYEKLMKKGFKKEELSKVHAPIGIKLNAQTPAEIAVCIAAELINCRANKEK"
     gene            7193..7954
                     /locus_tag="KRO40_000570"
     CDS             7193..7954
                     /locus_tag="KRO40_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M48 family metallopeptidase"
                     /protein_id="HBH2091409.1"
                     /translation="MNTGSKDIDTLKVNFRGIEIKAVLVYKNRKNISIKIDPFGKITV
                     MSPPKISKKIIKDIIIEKGDWILKKSEKCKGREEVYKQRMFITGEKFLYLGEEYHLVI
                     KELLRDSVKKSNCRITINEYQIVVQTNDTSTDFIKKSLKSWYKMESERIVLERIDFLK
                     LNCEIMKQLVPASVKVKEQNKRWGSCTAQKNIYINSKISMARLDVIDYVIIHEFSHLV
                     HMNHSKKFYDLVKSIMPDYKDKENWLKINGYKIII"
     misc_binding    8115..8372
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            8485..8724
                     /locus_tag="KRO40_000571"
     CDS             8485..8724
                     /locus_tag="KRO40_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH2091410.1"
                     /translation="MENTVYAKLNQGIDSFLRVAMTLRRREVDIQSISMTVDNMNNSG
                     IKLIVNEEKTSLDSVLNHMKKLHDIREITVERMRH"
     gene            9028..10023
                     /gene="ilvC"
                     /locus_tag="KRO40_000572"
     CDS             9028..10023
                     /gene="ilvC"
                     /locus_tag="KRO40_000572"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HBH2091411.1"
                     /translation="MKMARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVH
                     VVIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKE
                     GQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDYT
                     KKATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVD
                     AGYQKEVAYFECLHEMKLIVDLIYEGGFERMRYSISDTAEYGDYVSGKRVITDVAKQG
                     MQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRNLRSMMSFLK"
     gene            10076..11764
                     /gene="ilvB"
                     /locus_tag="KRO40_000573"
     CDS             10076..11764
                     /gene="ilvB"
                     /locus_tag="KRO40_000573"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biosynthetic-type acetolactate synthase large
                     subunit"
                     /protein_id="HBH2091412.1"
                     /translation="MNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHI
                     RTSHEQGLVHAADGYARSTNTVGVCFTTSGPGATNAITGIATAFMDSSPMVVISGQVP
                     TSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVDVP
                     KDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPIIYA
                     GGGVKSSDSEEILEKFATKIDTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALS
                     NSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKNIESNVSLVGDVKLVLS
                     LLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDV
                     GQHQMWAAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRM
                     NCNELATVANYNVPMLILLLNNRTLGMVRQWQKLFSNQRYSQTDINENVDYVKLVNAY
                     NIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALENLICN"
     gene            11975..12652
                     /locus_tag="KRO40_000574"
     CDS             11975..12652
                     /locus_tag="KRO40_000574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH2091413.1"
                     /translation="MFKHDKALLKEVKVERPNPQYAVLMQEQLGGANGELKAAMQYLS
                     QSFRIKDPQIKDLFLDIAAEELSHMEMVAQTINLLNGHDVDYNAVNTGEIETHVLTGL
                     SPVLINSSGAPWTANYVTVTGDLVADLLSNIASEQRAKVVYEYLYRQIDDKYVKETID
                     FLLNREEAHNALFRDALNKVKDTGSNRDFGVTEDSKLYFDLSTPGPNHDTKIDINPPS
                     FEKPLKK"
     gene            12826..14862
                     /locus_tag="KRO40_000575"
     CDS             12826..14862
                     /locus_tag="KRO40_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin domain-containing protein"
                     /protein_id="HBH2091414.1"
                     /translation="MDSNRKPNNLINEKSPYLLQHAYNPINWYSWNDEAFKKAKEEDK
                     PIFLSVGYSTCHWCHVMEKESFEDEEVAEIMNRNFVAIKVDKEERPDVDSVYMTVCQA
                     MTGSGGWPMTIIMTPDKKPFFAGTYFPKYSRYNRPGVIDLLENVSEKWNTSRDILIKS
                     GDEIIEALKDDFGVKNTEGDLSKEMLSSSVRVFKAIYDEKYGGFGNAPKFPSPQNLMF
                     LMKYYSIEKDKDVLKMVEKTLDGMYRGGLFDHIGFGFSRYSTDKKWLAPHFEKMLYDN
                     AMLTIAFLDAYKITKKELYKEIAIKTIDYVVREMKDKEGGFYSAQDADSEGEEGKFYT
                     FNPLEIIEVLGEEDGTFFNNYFDITSSGNFEGKSIPNLIKNKEYERHNEKIADLSKKV
                     FEYRKERTSLHKDDKILTSWNALMIVALTKAYSTLKNDIYLEYSNKCLNFINNNLVNE
                     SGRLLARYRDGSSDYLAYLDDYAFLIWAYIELYESTFNMKYLEKALNLNESCINLFWD
                     YEKSGFYIYGKDSENLIARPKDLYDGAIPSGNSVQLYNLIRLAKITGDNRLEEMSYKQ
                     LKLYVDNVKSSPTGYSFYMLSLMFELYSTKEIICIFKEDSDLIAFKELISENFIPNAT
                     FLAKKYNEENTIIGFLNNYRLKDDKISYYVCQSNSCSQPINDLQKLKDMILGVE"
     gene            complement(15053..15619)
                     /locus_tag="KRO40_000576"
     CDS             complement(15053..15619)
                     /locus_tag="KRO40_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2091415.1"
                     /translation="MDYSNELKELFLMNQTYATLFTLTNKIQIEGDKYFGILTSRQYM
                     TILSILHLPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKV
                     TDLGKKVMVTCSRTGINFMADVFHEFTKDELETLWSLLKKMYRFNGEEQDGFEEDANF
                     MEYEEIDKIKSEALEEFAKRRNRVNKKD"
     gene            complement(15916..17109)
                     /locus_tag="KRO40_000577"
     CDS             complement(15916..17109)
                     /locus_tag="KRO40_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005336078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH2091416.1"
                     /translation="MKEKRRDSKGRILHTGESQRTDGKYLYKYVDAFGNTKYVYAWRL
                     TPTDPTPKGKREKPSLRELEQQIRRDIEDGIDSTGKKMTLCQLYAKQNTQRANVKKST
                     QKQREQLMRLLKEDKLGARSIDTIKPSDAKEWALRMKDKGFSYNTINNHKRSLKASFY
                     IAIQDDCVRKNPFDFKLSEVLENDTKEKVALTEEQEQALLSFIKTDNVYHKYYDDVLI
                     LLKTGLRISELCGLTVADIDFKNEVVIIDHQLLKSKEQGYYIETPKTKSGTRQVPLSK
                     ETIQAFQRVMKKRPKAEPFVIDGRGNFLFVNQKGKPKVAIDYNALFVRMVKKYNKHHK
                     DNPLPHITPHTLRHTFCTRLASKNMNPKDLQYIMGHSNISITMNWYAHASIDTAKSEV
                     QRLIA"
     gene            complement(17188..17391)
                     /locus_tag="KRO40_000578"
     CDS             complement(17188..17391)
                     /locus_tag="KRO40_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH2091417.1"
                     /translation="MNNNDIPVWEKYTLTIEEASKYFRIGENKLRRLAEENKDAGWLI
                     MNGNRIQIKRRQFEQVIDKLDAI"
     gene            complement(17391..18482)
                     /locus_tag="KRO40_000579"
     CDS             complement(17391..18482)
                     /locus_tag="KRO40_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018594174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HBH2091418.1"
                     /translation="MTTHKNLSVKIDYISIVFDTATAEDVIMHILGLPTDIFNVYPAS
                     VKYKTYQARWQIGDIYVSGDARKTEDNPQGLGCYLVMTGRGCDDIFRILDSRNYTFGD
                     MFRRCERRYGLDNFHFTRLDIAIDDKNEKPFFTIEQIKKKCEKEEFISNSEGYHFDES
                     KFDDFDTAKTVYIGAGKSGLSYRFYDKDKEVCSKHNKTLDEVGSWKRTEMQLRDDKAH
                     AFAMTFKDRPLELGELAFGLLANNLRFVVPNRNESNKSRWKTCRFWERFLGAVEVLKL
                     QVPKQQNSLEETQQWLTEGGVISAVKSFYFLEEHNALGGLEKVGTMLDKARYSNSLSS
                     KLTAHLQRINRTDLIPYIQYDTKHGKGGI"
     gene            18939..19610
                     /locus_tag="KRO40_000580"
     CDS             18939..19610
                     /locus_tag="KRO40_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008393244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091419.1"
                     /translation="MEHYEKKISFLGENIQTIRKHRGMKQQELADKIGINMQSLSKIE
                     RGVNYPTFDTLEKIMDVLGVTPNELLSGEWKYIDHTEPYIMDIIKREQDFNVSLDYLS
                     ENEFFNDEKECRFYKEYKLIQYIHNYITNEVTELEELMEIKQLIQRQKIERMMKVHKE
                     MRGLDRYREQPKEYKYHDPYDDWIFRQLADIDNRNNIPDTSPQLDFNEADYEDYLKAK
                     WNRGL"
     gene            19864..20244
                     /locus_tag="KRO40_000581"
     CDS             19864..20244
                     /locus_tag="KRO40_000581"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091420.1"
                     /translation="MIVFWIIGILFLIVGLIVSVPTIIKFIKCKEHTTGKIVSIDSSS
                     NGYARAVYEYIVSSSKYTNKTNWTPHHIFHLDGECHVIYDKNNPNSSYIKKSGQYIRC
                     IVGILFAMIGIGVLLLGIFLITVL"
     gene            20668..21039
                     /locus_tag="KRO40_000582"
     CDS             20668..21039
                     /locus_tag="KRO40_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005947439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091421.1"
                     /translation="MWLLGSIFIFTSLLILYIKYRVVFTGEKCKGKIIDIVEQNAGYV
                     VGGVNVKKHAYIVKIKNKKYHTAHGCIFLSLGKRNIGKEISVFKNEKYGNEVFKCFDF
                     RIEIVALLVFLFGVFMIYSAL"
     gene            21113..21637
                     /locus_tag="KRO40_000583"
     CDS             21113..21637
                     /locus_tag="KRO40_000583"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091422.1"
                     /translation="MENLSAYRYCIAMKKGRKILNLIVGCLMILISIIFITTTVFSCI
                     FMQEFVYYTFLAIFLIIIPLPLFIFGIIGIVSATKRVEVYKGKVIYHIGFKNKEYRMS
                     DIKTSKTKSETYRTGLDYGNIVPTYSYDKLTVFYDKKGKKIFKFGLAYDNVERLKADV
                     NNTQKSIAKQHNKN"
     gene            21928..22248
                     /locus_tag="KRO40_000584"
     CDS             21928..22248
                     /locus_tag="KRO40_000584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TfoX/Sxy family protein"
                     /protein_id="HBH2091423.1"
                     /translation="MASSKDYLQFVLEQLSELQEITYRAMMGEFIIYYRGKIVGGIYD
                     DRLLVKPTKSAISYMPAVTYEIPYENAKEMLLVEEIDNKDFLMGLFNVMYDELPTPKP
                     KKKK"
     gene            22654..23589
                     /locus_tag="KRO40_000585"
     CDS             22654..23589
                     /locus_tag="KRO40_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2091424.1"
                     /translation="MKCTNFTFKGEEGLDIYTYKWEDENIKKPKAVIQIAHGMAETAQ
                     RYETFAKVLTKNGYIVYINDHRGHGKTAKIIENVGHLAEKEGFRCLVEDMYTLTNIIK
                     KENEDLPIYLFGHSMGSFASQRYIMDYSNNLSGLILCGSNGKQGIILNLAHLIINREI
                     KKYGRRSKSNKINNLIFGGEIIRRNEKTKFDWLSRDKEQVEKYINDPFCGVVCSCGFF
                     YDLVQGLKEIEDKENLKKVPLDIPIYIISGDKDPIGKNGKGVLRLRDRYIKLGVKDVT
                     CKLYKDGRHELLNEINREEVFEDIICWLNNKIEIL"
     gene            24060..25274
                     /locus_tag="KRO40_000586"
     CDS             24060..25274
                     /locus_tag="KRO40_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091425.1"
                     /translation="MQIKIGKVIQCLRKERNLTQEQLAKFIGVSTPAVSKWESGNSYP
                     DIELLPLLADFFNVSIDKLLNYKIDLSEEEVMKIYKELESGFARIEIDLSTEEPKEEF
                     RQDLESVKKLSNMYIEKYPKSYLLKLRICSLYQMYSYKFGKSELNDRVKETTNILEDI
                     VRNTDDIQIKETALIILSNAYCMLEDYEKAELYLNMIHKSIGDTSVNLAMIYLKQNRL
                     EEAEILLQNKLFSNVFNISMDCKGIINVYKNQYKELKKKLENRNFNKNAIEREMEYIK
                     NKLLGYANLSLEIKKMLSEDKGAFFSMYMDYMELSLIFLFFNMKEEAKKALYSLKEIL
                     EKYPIHESLDVSQMRFFDKVESKNLYTFNIYTNLLIVLNDDSYNELREEPIFKDVIEK
                     ILDMEKMLKNKE"
     gene            complement(25694..26215)
                     /locus_tag="KRO40_000587"
     CDS             complement(25694..26215)
                     /locus_tag="KRO40_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091426.1"
                     /translation="MKFEWLRTSENKLYYKAMELYKISFPFHEQRKSSLQAEILKNKE
                     YQFNLIYDKNQFVGIILCWETDDFIYVEHFCIFPEMRNNRYGQRALELLNKKGKTIIL
                     EIDLPIDEISIYRKAFYERVKYKTNNYEHIHPPYHKKFNGHNLIVMSYPEKLSKMEYD
                     KFNHYLRNNVMSF"
     gene            26571..27368
                     /locus_tag="KRO40_000588"
     CDS             26571..27368
                     /locus_tag="KRO40_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBH2091427.1"
                     /translation="MEKREKRIIISSLLSVSILMGLVSIYSILNKEDIILTVKGQEQK
                     VSSFKKTVEELLDEQGVKYNSEDKINPSLDTELKDDMKIKVVKVTKSKKEEIEKIPFD
                     TKHVNDSNLLKGKSKVYQEGQEGEKKLVYNLTYHDGKLVKKVLSKEVISKEPTTKIIK
                     YGTKEKVLIASRGANIRGGKHMKVVATAYAGDTITSTGTTPRWGVIAVDPRVIPYGTK
                     VYIPKLGMTFVAEDCGGAIKGNRIDIFMNSEGKASNWGRKSIDIYLH"
     gene            27478..28068
                     /locus_tag="KRO40_000589"
     CDS             27478..28068
                     /locus_tag="KRO40_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HBH2091428.1"
                     /translation="MKIVCLGDSLTYGFGVSRSNSWTNIVNKETRLEIVNKGINGDTT
                     SGMLARFNEDVVKNSPDIVFIMGGTNDFIAGAGNEIINSNIMAMVHQSYSKNIIPIIG
                     IPLKPDIPNVREDWSCFTDFNIVSQNLESYSYWIKKFCMTFNTNFVDFYSEYNKNMEL
                     EGYKKLYFDGLHPTKEGHRIMADIFINSINKYIEEL"
     gene            28134..29831
                     /locus_tag="KRO40_000590"
     CDS             28134..29831
                     /locus_tag="KRO40_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBH2091429.1"
                     /translation="MDYTKTYEEWIKGSYFDEDTKLELENIKNNEKEIEDRFYKDLEF
                     GTAGLRGIIEAGTNRINKYTVRRATFGLANYILENTTKEETSRGVVIAHDNRHKSRQF
                     CIESANTLAACGIKAYIFDSLRTTPELSFAVRSLNAIAGIVITASHNPPEYNGYKVYW
                     EDGAQVMPEIANAITEKVNSIHDYSTIPTLTEANKNLVVLLDESQDTKFIEAVKSQII
                     RKDLVKNVGKSFKIVYTPLCGTGNVPIRRALKEVGFENIIVVPEEENPDPNFAGLDYP
                     NPEEKKALNRGILLAKEKGADLVIATDPDCDRVGVAVKTTTGEYALLTGNQIGGMLTH
                     YIIEGLKENNKLKENPTIIKTIVTSEFGADIAKANNVDVLNVLTGFKFIGEKIKLFEQ
                     NKNRSYVFGYEESYGYLVGTHARDKDGVVSSLLISEMAAFYYSKGMSLYDGLIELYKK
                     YGFFKEQTISLTLKGIEGVEKIKEIISYFRENQIDYINSIKVVDKKDYKNGIDNLPKS
                     DVLKYFLEDESWVAIRPSGTEPKLKFYIAVKGASDIEADKKIQGLKKYIDDMVEKLK"
     gene            30045..30884
                     /locus_tag="KRO40_000591"
     CDS             30045..30884
                     /locus_tag="KRO40_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HBH2091430.1"
                     /translation="MFGIDKKLIEYIIAKSNYSELSSKSAEVSFFLMLSIFPFLIFTI
                     SSIAYIPILHLNKYIALFRNMMPEGAFAVLSSIIVSAIDNRNLKFLAVSFVLTMWTFS
                     RAVKALIKGMNRAYKVKETRSFFKILSISFLFTIMLLVLIFLSMIFLVYGEKIGYFIF
                     NLVGLDEIFIKIWDILRYTVGIITIIVIFTLLYKYTPNKKLTIKESAPGAIFATFAWF
                     LVSFLYSYYTNYYANYEVIYGSIAEIIVLMTWMYFSSWSIVIGYEVNSRLYFRKIRHE
                     MLK"
     gene            31401..33257
                     /locus_tag="KRO40_000592"
     CDS             31401..33257
                     /locus_tag="KRO40_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBH2091431.1"
                     /translation="MDTHNKYVNFIKNIPVPFLYCRIVKRQEDIEYRVEYISKGMGKV
                     LQLEEGICDKNILDVLPVFKSKKYFKELFSNEVDCIKRYIPTLKNWINIKKQIIGDSY
                     IILYFGKIVFDYRQIIDSFDKKEKVAYIKDEEGIYIDCSENLIPILNNNIKTTKDIFG
                     KNDIEVWGENTGKLFRDDYREGVSSKKRFLQNLFEYEETFFMVEKYFLYDEDELLGTI
                     GIVDNIIYSGYSNRNYNSKDLMKMIEHSIPENMFYKDVYGNYIGFNSGFLNLACMNKE
                     ELLGKNSYKISEEEALIDKIFESDKGVVENKKVVTFELNISMNDENKCIEITKRPFFD
                     SYGSVIGIIGTARDISRRKRLEEEMDKTRMEFFANLSHELRTPINLISSSLQVIEKKE
                     ADLIESNDTLKRNLGIIKQNGNRILRLVNNVIDFTKMQSGYLDFKPEESDIIAFIEEI
                     CMSVADFASQNNIQLTFDTEIEEFSMLFDSEKLERIILNLLSNGIKYNKKDGKINIFL
                     YVKDNVFNMKISDSGIGIPKEKIDKIFNRFEQIDNELSYRVKGSGIGLSLVKSLVELH
                     EGSISLKSQLGIGSEFIVSLPVRSKNNIEKYNHKREISNELSKKLEIEFSDL"
     misc_binding    33340..33580
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     misc_binding    33646..33881
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            33966..35183
                     /locus_tag="KRO40_000593"
     CDS             33966..35183
                     /locus_tag="KRO40_000593"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBH2091432.1"
                     /translation="MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEK
                     HKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSLSYIKKALNNKIHVVTANKDLLA
                     ECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
                     KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYL
                     EGITDIDEKDIEYAKKLNCKIKLIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNA
                     VIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDSFTKDKIQVNKIVRE
                     KCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEINNSLCLIKDK
                     GYCEKMNKMLKIS"
     gene            35300..35782
                     /gene="cdeM"
                     /locus_tag="KRO40_000594"
     CDS             35300..35782
                     /gene="cdeM"
                     /locus_tag="KRO40_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeM"
                     /protein_id="HBH2091433.1"
                     /translation="MENKKCYSEDWYERGESTAKWFQNDREEYEREAYDEDRERRGSN
                     CGCSDSGENRPRNCERFRREAEIREREAREAFCESSEKKKEALAYECEARKLWEEAEK
                     YWDEYSKYNYKGIEYLAEAARLFDEGMECEARRNGNNGGNNNNCCHKCHKCNCNCCRK
                     "
     gene            36047..37312
                     /gene="hisD"
                     /locus_tag="KRO40_000595"
     CDS             36047..37312
                     /gene="hisD"
                     /locus_tag="KRO40_000595"
                     /EC_number="1.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol dehydrogenase"
                     /protein_id="HBH2091434.1"
                     /translation="MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKF
                     DRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKNIREFAKAQKLSFENPFEKEIYP
                     GVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
                     PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQ
                     VGIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNI
                     ESMLKDLPTKDIAYSSWENNGEIILVDDMEEAIKISNFYAPEHLEVAVNEYNDICDRL
                     TNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAI
                     QSLAPVAEKLAKEEGLYAHAKAAEVRFKK"
     gene            complement(37515..38267)
                     /locus_tag="KRO40_000596"
     CDS             complement(37515..38267)
                     /locus_tag="KRO40_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2091435.1"
                     /translation="MSYFQYQGNSCFYKEYGQGKPIIFLHGNTGSSNMFKALVPLYAE
                     NFRCILIDFLGNGQSDRVSQFSPDIWHDEALQTIALIEHLNCGKVGLIGTSGGAWAAV
                     NTGLERPDLVEAIIADSFDGRTLNDNFIDNLITGREKSKQDIQARKFYEWCHGKDWEN
                     VVNLDTKALLQCANEKRPLFHKELCKLEMPILFTGSKEDEMCRHNLEEEYKQMATFIS
                     KASIYIFSQGGHPAILTNADEFAQLAKVFFKY"
     gene            complement(38385..38654)
                     /locus_tag="KRO40_000597"
     CDS             complement(38385..38654)
                     /locus_tag="KRO40_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091436.1"
                     /translation="MSYQNSIDLLPKELIEQVQEYIDGKVIYIPKKQEHKKHWGENTN
                     TKQVLASRNSQICINFQNGMSIKQLSEKYFLTEKSIQRILKQQNL"
     gene            39129..40223
                     /locus_tag="KRO40_000598"
     CDS             39129..40223
                     /locus_tag="KRO40_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH2091437.1"
                     /translation="MKNIVGKPQTIKKVNEDLIKNIIKNEGPITKPEISSITELSLAT
                     VNKIVEQLALKNEVKVSGLSESTGGRRAQLFEINANLEHIIALYYYRNCCIGVVANLL
                     GEIIYQEEFNIRMDTYENVNQDTFFVIDTLIKKEKGNNIRAIGIGVPGVVKKGVVKNI
                     PTIKSWEGINLENLIKSKYNTKVFIENDTNITTIGIYQKQYKDKYKNMALMYLEDGIG
                     SGIVINGELYLGSTNFAGELSYLNIEFGKYNSNNLNLEDYIMSLRKRYLESKDNKFKK
                     EILSIISNFIRTLVCVLNPQAMIIQCSILTKSDMEFIEKDVSNNVGEENFPKLIKVDS
                     LREGSINGVISMCLKETDYQYSLSNKKGGY"
     gene            40225..41175
                     /locus_tag="KRO40_000599"
     CDS             40225..41175
                     /locus_tag="KRO40_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine kinase"
                     /protein_id="HBH2091438.1"
                     /translation="MKYLVSIDGGGTKTKFCVSDLDGNILKEHTTGSTNYKSVGIKKT
                     YENINNGFKKILKDLYIDYDDIEYTVFGISGCDSPNDYKIIMDEILKIGINKEKIYLA
                     NDAVLAFYAQADSPGLVIVAGTGSIILGIKEDGEIYRVGGWGYNFSDLGSGYDIGRKL
                     LKKVLLYCDECHEYSDLFSCVLDFFGANSFEQLAYMITDINDNVEIANLASLVIDCAE
                     QGDKLAIEILRESSTELSKLAQVILRKISNPMKMDKSEINIVLSGGTLNKTVYAQMLM
                     NNLKTENTDKNLKFISQENQPVYGGIRLAMALANRRVKHG"
     gene            41168..42352
                     /locus_tag="KRO40_000600"
     CDS             41168..42352
                     /locus_tag="KRO40_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091439.1"
                     /translation="MDRKKVIVQIFTGGFKAKEIKFNDIKCKLLELLDCIDIEKVIMG
                     WSVDEELYVETKKLLNKYNVELYLWLPCFSEIGLLEKSNLLIDYMGKEVKGYALQEDE
                     NFEFYCPNNKENIKNIKKIYSTYFSDIKFDGIFLDKIRYGSFSNKLNGVFNCFCKDCL
                     NIYKKNNIDKESLMREMNNVSKGVIDNEDTPFGITEYINGKYKFKNKIWEDFFETKNQ
                     NIYKALLEISSYFKSKGLKIGIDAFSPFISYFTGQDLEKLQEVADFIKPMMYRTTKAP
                     AGLPFEFERFIDESIHKNKEIGKRNFLDILGIKEYEGDVYPIEFVLEEIDFMTRNLNK
                     DIYVGVEINKKEIISPVTPKYISENISNINKTTVKGYVLSWDLLSAPKENIDEIIKWF
                     RN"
     gene            42365..43861
                     /locus_tag="KRO40_000601"
     CDS             42365..43861
                     /locus_tag="KRO40_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBH2091440.1"
                     /translation="MSKILEIQQIYKSFGKVDVLKGINFELEKGEVRALLGANGAGKS
                     TLIKILGGVHSQTKGKVILTGNEIMFKNPHHSKENGISIIYQELSLIPTLTVLENIFL
                     GREILKGSVFLNKKDMLEEYMKICEDFDFNIDPHIVVSNLSVANQQMVEIMKAVSCNS
                     EIIIMDEPTTSLTNNEKDGLFKIISRLKSKGKTIVYISHILEEVFKVCDSASIMKNGI
                     MIGTYDVEDLTKLKITQLMTGNDNHKLIEKKDYTFAKYEEPPVLEVKNISWSNKIKNV
                     SFKVYRGEVVGLAGLVGSRRTEIINLIFGIDNKDSGDIFINGKKVDITSPKVAIKNKI
                     GLIPEDRKNLGLILEQAIYTNSSSVQIDKFKKFLFIDRNKEIEFSKKGVKELGIKVSD
                     VKQEVKELSGGNQQKVVVSKWLEKDLDLIIYDEPTKGIDIAAKEDIFNTIKEFSSKGI
                     GVIFISSDLEEVIRVSDRILVTREGSIVDDLKNENIQVQDIMNSIFNV"
     gene            43884..44834
                     /locus_tag="KRO40_000602"
     CDS             43884..44834
                     /locus_tag="KRO40_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091441.1"
                     /translation="MKKAFEKLNLRDYGVLLGFLALCIAISIATPSFLGKQNILNLLR
                     QSSIIGIISAGMTFVIISGNFDISVGAVAALAGAITMKFATGGTNLFASMFLGVAICA
                     VIGLINGIVVAKINVPSLIATMAMVTIVRGLLLMLTGGYPITENIPILDYIGNGYLFN
                     IPIPVVIFFIVVLASFIVLNKTKFGRYVYSVGGNQEASKLNGINVDSHKVKVFIINAV
                     LAGIAGIVLTGRLGTATAIAGEGYDMDAIASVVIGGTSVAGGSGSVLKTVIGVLLMSV
                     INNSFNLLGIDVYFQYIFKGLIILAAVGFDSYSKKKLASR"
     gene            44855..45817
                     /locus_tag="KRO40_000603"
     CDS             44855..45817
                     /locus_tag="KRO40_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH2091442.1"
                     /translation="MKKLMKHLALLLSLVMIFGLVGCSNGGDKEKNGEKKIAVLLPGS
                     TGYFVATKQGIDAKSKELGVSVEYADAQWDASKQLSQAEDFMAKGVDMIALCGVDSAV
                     SERIVKAANDSDVPIVAFTNSIGSNPTGEFKGLVTYIGQNEEETGALTGKIAKNLLGE
                     TGGKAVLIEGVPGTTPQVLRKKGLEKELKDSNIEIVYNQTSNWEKEQALKVTEDLIQK
                     KTDFNVIICQDDNSATGAGQALKDAGLKDKVKVIGLGGSKDGLKAITDGLIDGTTYMS
                     AVEEGGLVIEKASKFLKGEKIEPVTQIKQVEVNKDNISEFKGEW"
     gene            46189..46821
                     /locus_tag="KRO40_000604"
     CDS             46189..46821
                     /locus_tag="KRO40_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2091443.1"
                     /translation="MARRLFLERIGLIFLGSAILAFGVYNFYYLNNITEGGVLGILLL
                     LKNLFNIQPAIANVVIDSLLLLVGYKFFGKKFLIYSIVASITFSVLYDLFEAIGPLVP
                     QSQNMLLSTILAGVTVGTGVGIVVKAGCASGGDDALALVISKTTSLNIGQVYLATDVI
                     VLLLSLFYLSAFDIFYSLIAVTISGKVIDFIYYHGKSLDMDISNDIVPEC"
     gene            47232..47324
                     /gene="kdpF"
                     /locus_tag="KRO40_000605"
     CDS             47232..47324
                     /gene="kdpF"
                     /locus_tag="KRO40_000605"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: protein motif:HMM:TIGR02115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit F"
                     /protein_id="HBH2091444.1"
                     /translation="MEGLPMWFLAVVIIMLIIYLVYALINPEKF"
     gene            47365..49047
                     /gene="kdpA"
                     /locus_tag="KRO40_000606"
     CDS             47365..49047
                     /gene="kdpA"
                     /locus_tag="KRO40_000606"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015391009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpA"
                     /protein_id="HBH2091445.1"
                     /translation="MFMVQIVIVLAIFMILVIPMGKYLYHIATNQKTFGDRLFDKVDN
                     FIYKVCSIDKKKEMNWKQYALALLFTNAVMVFIGYIILRTQSMHIFNPSGIKSMEQGL
                     SFNTIISFMTNTNLQHYSGESGLSYFSQMTVIIYMMFTSAATGYAAAMAFVRGLVGKK
                     KTLGNFYVDLIRITTRVLLPGALIIGLILVTQGVPQTFAGTETVTTIEGKLQDIARGP
                     VAALESIKHLGTNGGGFFGSNSSHPFENPTIISNIVEILSMMILPGACVVAFGHMIKN
                     KKQGWVVFGAMSIIFLIGLVVCFKAESAGNPILSQLGLNQSMGSMEGKEVRFGIAQSS
                     LFTTVTTSFTTGTVNNMHDTLTPLGGLVPLLNMMLNVVFGGKGVGLMNMLMYAIIAVF
                     LCGLMVGRTPEFLTKKIEGKEMKLIALLIILHPLLILMFSGLSVAIPAGLEGISNPGF
                     HGLSQVLYEFASSAANNGSGFEGLGDNTMFWNITTGIVMFFGRYVSIIVLLAISSLLA
                     SKKAVNESIGTLRTDNFTFTIVLVLVVLIVGALTFFPALALGPISEHLVLWH"
     gene            49072..51129
                     /gene="kdpB"
                     /locus_tag="KRO40_000607"
     CDS             49072..51129
                     /gene="kdpB"
                     /locus_tag="KRO40_000607"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010966942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpB"
                     /protein_id="HBH2091446.1"
                     /translation="METKKTKFITKDIFKTSIIEAFKKLNPKYMMKNPVMFVVEIGFI
                     VTLILTIVPSLFGDEGNNLRAYNGIVTIILFITVLFANFAEAVAEGRGKAQADTLKKT
                     RKDTVARVIDTLGNEKMISASELKLGDIVLVNAGEVIPNDGEVIEGIASVDESAITGE
                     SAPVMRESGGDFASVTGGTTVVSDWLKIRITTKPGESFLDKMIALVEGASRQKTPNEI
                     ALNTLLVGLTLIFMVVLISLYPMANYAGVKIPISTMIALLVCLIPTTIGGLLSAIGIA
                     GMDRVTRFNVIAMSGKAVEACGDVDTMILDKTGTITYGNRLASEFIAVGNADSKDLIN
                     YSVMCSLKDDTPEGKSIVDLGMKLGSTGKTKEAEEAEFVEFSAQTRMSGINLADGRAI
                     RKGAYDSIIKRVKESGGTVPEDLEENVNRVAKLGGTPLVVCVDNEIYGIIYLKDTVKS
                     GLVERFARLREIGIKTIMCTGDNPLTAATIAREAGVDGFIAECKPEDKIDAIKKEQLE
                     GKIVAMTGDGTNDAPALAQADVGLAMNSGTTSAKEAANMVDLDSDPTKILEVVEIGKQ
                     LLITRGALTTFSIANDVAKYFAIIPAIFTLAIPQMEILNVMKLSTSFSAILSALIFNA
                     IIIPCLIPLAMKGVKYRPMKSQAMLMRNMLIFGLGGVIVPFLGIKLIDLLITPLVMVL
                     NLG"
     gene            51148..51774
                     /locus_tag="KRO40_000608"
     CDS             51148..51774
                     /locus_tag="KRO40_000608"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit C"
                     /protein_id="HBH2091447.1"
                     /translation="MKTLKPALLVSIVLLVVCGLVYPLVLTGVSQVAFKDKANGSMIE
                     VNGVKVGSELIGQSFTDVRFFKGRVSSVNYNTYTKEDLVPDKDGNTSYGGVSSGSFNY
                     GATNPELHDRVQKDIEQFLKDNPTVKREDIPTDLLTASGSGLDPNISPASAKIQIPAI
                     AKASGISESKLQKIVDDNTSKKLFGVLGEDRVNVLKVNVEVAKILGLI"
     gene            52011..52919
                     /gene="cysK"
                     /locus_tag="KRO40_000609"
     CDS             52011..52919
                     /gene="cysK"
                     /locus_tag="KRO40_000609"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HBH2091448.1"
                     /translation="MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIK
                     DRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALSMIGKLKGYEVVIVMPETMSVER
                     RDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
                     EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHK
                     IQGIGANFVPENYDSSVVDEVILVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEM
                     AKKYPDKKIVTVAPDGVDKYMSMGIF"
     gene            52946..53536
                     /gene="cysE"
                     /locus_tag="KRO40_000610"
     CDS             52946..53536
                     /gene="cysE"
                     /locus_tag="KRO40_000610"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HBH2091449.1"
                     /translation="MFKKINKDIEYIMKNDPAARSKIEVFLLYPSVHAMIMHRMAHAL
                     YKKKKLFTARLISQISRFMTGIEIHPGAKMGEGILIDHGMGVVIGETAEVGNRVTIYQ
                     GATLGATGKDTGKRHPTVGDDVLIGAGTKILGPLNIGSNSKIGANSVVVKDVPNGATV
                     VGIPAKIVKIRNLEPVKKNKKEVSYEYDELDNVYYI"
     gene            53696..53884
                     /locus_tag="KRO40_000611"
     CDS             53696..53884
                     /locus_tag="KRO40_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBH2091450.1"
                     /translation="MKANVNQDTCIGCGLCPSICPEVFDMKDDGKSHVIVDEVPSDAE
                     ESAAEARESCPVDAIDVH"
     gene            complement(53938..54807)
                     /locus_tag="KRO40_000612"
     CDS             complement(53938..54807)
                     /locus_tag="KRO40_000612"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HBH2091451.1"
                     /translation="MKLNRNDSCWCGSTKKYKKCHMDMDNKIDSFAKLGHIVPTHDII
                     KNESQIEEIKKSAVINTKILDYISDKIEIGMSTEDINKLVHDFTLQNGAIPAPLDYNG
                     FPKSVCTSVNNEVCHGIPSKDIILKDGDIINVDVSTIFNGYYSDASRMFMIGNVNENA
                     KKLVQVTKECVQKGLEVAKPWGFLGDIGDAINSYAKKNGYSVVREIGGHGVGLSFHED
                     PFVSYVSKKGTKMLLVPGMIFTIEPMVNEGTHEIFVDEENNWTIYTKDGKLSAQWECM
                     VLVTETGVEILTE"
     gene            complement(55004..56248)
                     /locus_tag="KRO40_000613"
     CDS             complement(55004..56248)
                     /locus_tag="KRO40_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091452.1"
                     /translation="MENNLNTAKRNNTELLQNDSLKVNLQIGVDFTLLSKSLKAFYKK
                     EKDFYCIALAPCNVSSEKANRKISIYDMIKEINILIESITDKNELLSEELFTNNLSEF
                     YDESLDEIYIDLKQAYLYIKKNTDSLNIEDSIEYVFDVDISNDIKAKENPLINFNSLS
                     LVVWSGETKHILQQMNILDLEDIHSYSIENNTNITIYENNTLQYKFNEESENIKDSSI
                     DIIEQMLILPDDLNYDKDEVENMKNRLAKINIKYLQTLKEKDIKIKLINSNLTDEPEF
                     SDLKYQLPPCWVRSGKTWKDVPGIYRNNSIVAKIGYSNPSYANVHSSKNLELHETAHA
                     IDKNVLNKKSNSEEFMEVFAQERYKLYDPKQVAHAYISKFIEEFFAESFVHYYLDEDS
                     KNTLKENCPLTYDFLEKLELNY"
     gene            56539..56850
                     /locus_tag="KRO40_000614"
     CDS             56539..56850
                     /locus_tag="KRO40_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBH2091453.1"
                     /translation="MYFTYIIRCKDDSLYTGYTSNIVRRMNEHKLGINSKYTRAKGFE
                     KLEVYFVTNTKSNAMKLEYYIKKLTRNKKLSIIKNPSILINLIDNKEDYIIGKEIEQL
                     T"
     regulatory      56943..57035
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            57135..57929
                     /gene="thiD"
                     /locus_tag="KRO40_000615"
     CDS             57135..57929
                     /gene="thiD"
                     /locus_tag="KRO40_000615"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HBH2091454.1"
                     /translation="MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAIT
                     AQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKIGMVSSPEIILEIVENLKKYNPK
                     YLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMK
                     RVGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSA
                     ITSYLALGYEITEAVNLSKIYITEAIKRSFDIGHGVGPVHHFYKFE"
     gene            57953..58741
                     /gene="thiM"
                     /locus_tag="KRO40_000616"
     CDS             57953..58741
                     /gene="thiM"
                     /locus_tag="KRO40_000616"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HBH2091455.1"
                     /translation="MYNLIKDVKKLNPLVIHYTNNVTINDCANVTLAVGASPLMSFSY
                     EEVEEMVSVANSVVINIGTMNSNMLDLFLLAGKAANKYNKPVVLDPVGVFASKARAEL
                     TSRLLNEVKFSVVKGNVSEIKFIGGFNVKGKGVDSFDEEEDSTEIIRKIAEKLECVVV
                     ATGKIDIITNGKGTYKINNGTDKLKGITGTGCMTASLIASFMAVTENILEAATMGVLT
                     MSLSGELANLNNPPIGTFKENLMNAIYQMDIDTLSKNSNIEFLN"
     gene            58764..59396
                     /gene="thiE"
                     /locus_tag="KRO40_000617"
     CDS             58764..59396
                     /gene="thiE"
                     /locus_tag="KRO40_000617"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBH2091456.1"
                     /translation="MIDKESLKKCLKLYLVTDSEMLKGRDFYKCLEDAISSGITTVQL
                     REKNASGREFLRKAMKLREITKRYGVKFIINDRVDIALICDADGVHVGQSDIDVREVR
                     KLIGNNKILGVSARTLEEAICAKNDGADYLGVGSIFTTSTKLDAKSASFETVKEIKEK
                     VDMPFVLIGGINLDNIDKLKCLESDGYAIISAILKAEDISKEVEKWTLKI"
     gene            59535..59837
                     /locus_tag="KRO40_000618"
     CDS             59535..59837
                     /locus_tag="KRO40_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091457.1"
                     /translation="MIRILLVCVGGMSSTLLVNKMEKDAKKRNIDCKIWAVGEGDIKS
                     ELDNFDILLLGPQLRFMLDDVKSIVGDRAPVSIIDMVNYGTCNGHAVLNSVLEILK"
     gene            complement(59903..60658)
                     /locus_tag="KRO40_000619"
     CDS             complement(59903..60658)
                     /locus_tag="KRO40_000619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091458.1"
                     /translation="MGMLNILWRSMKWRFKNPISFVVTILQPFLWLVLYSSIANQTMN
                     NININNYTAFILPGIIVLVVFSSCSSGGIINFIMKNSGSFYRVLIAPISRYSIVLGQL
                     LEAILVSFIEVTILCIVSIFFSVRIESGIGGILLMIVLIFMTAFFLSSLAYSISLLLP
                     NEIVYETIMTAIVLPIFFLSSALFPIESLSGGLKVAVMLNPFTHVINALRSLIFGETI
                     LIGDIMPVILLFLILCCSSFSLAMWRLKKEMVS"
     gene            complement(60646..61608)
                     /locus_tag="KRO40_000620"
     CDS             complement(60646..61608)
                     /locus_tag="KRO40_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091459.1"
                     /translation="MLAIEIDNLVKEYKNGVKALNALSFNVNAGEIFSLLGPNGAGKS
                     SLINILTTFYKPTSGNVTMFGKDLVDNPSWIRTQIACVAQQISIDEHLSLMENMVFQS
                     KMYKVEPQIAKQRIDSLIDKFDLSSYLKYPTSSYSGGVKRRLDIAMNMVSSPKILFLD
                     EPTVGMDVDSRKSMWDMLLKIRDEYGTTIFLTTHYLEEAEQLSDNICIMKNGKDLAQG
                     TPSSLRSYIRQNILRITFHNTEDIKKYKDAIKSTGLVKFMSVRENSIFISVNDSRTAF
                     TLINKWLLEHDIEFDAIEIVEPSLEDVFLALTSSKKSLKEEWEC"
     gene            complement(61612..62070)
                     /locus_tag="KRO40_000621"
     CDS             complement(61612..62070)
                     /locus_tag="KRO40_000621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH2091460.1"
                     /translation="MNCKIEIKNIESVTVATMRYNGPMTEATKYFPNVFKAIKGKSNG
                     APFFCYYDVDQKTGVAEMELCVPTAETPNRMGITTKEFPKTKALFFTHTGSYSNFPKT
                     YEMIFKYIHENNIKIQTPWREVFIKGPGMLIKGNPDNYITEIIFPLKEEE"
     gene            62425..62781
                     /locus_tag="KRO40_000622"
     CDS             62425..62781
                     /locus_tag="KRO40_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2091461.1"
                     /translation="MNFELDNTTPIYLQIVKYIKRQIVTGELKPGETIPSRREMALNL
                     KVNLNTVQRAYKEMGDMNIINTFKNYQSSVTVDENILKNLKLELINESLSVFIEDMKA
                     INVSKEEVLKIIEDKY"
     gene            62853..63569
                     /locus_tag="KRO40_000623"
     CDS             62853..63569
                     /locus_tag="KRO40_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091462.1"
                     /translation="MIEIKNVSKTYKRMQGLKIRKIEALKNVSFNIEKGKITALLGIN
                     GVGKSTMLKAIAGLINIDSGEIRIDGEKINEKVYNKLAFVPDVQSHFSNTTIKETFEF
                     MEIFYSKWNKEKSKEMMDIFKLDEDEIIDNLSKGNIARVKLILGFCQDPEYILLDEPF
                     TGIDLFKREEFIGVIAQYMEENQAIIITTHEIVEIESLVDEVVILDEGQIITSFNAEE
                     LREREGKSILDKMREVYKNE"
     gene            63562..64386
                     /locus_tag="KRO40_000624"
     CDS             63562..64386
                     /locus_tag="KRO40_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091463.1"
                     /translation="MNKLLYLINVDLRRSNKFYIAYISFFSLITLSLNLFEINKFKNS
                     KFIMNLAIEDFGGIFYGLGILSNLGFIQSILFFGILGLFIYYIFMWKREFFSNNQSIY
                     TLMMLPQNKFKICISKSIALITMIYGFLISQTATLFICKYIFNFIFRNMPIINMNFAK
                     DLYYLNLKSIPIDFISFMAIYVFLLLIAISIVNCCILFIFSYINKFYVILITLLIIAG
                     LYFSTIYINIITLFRKYYSLIGFQFNNLVAGLLSFLIIMFILNGISYLLIKKKVSL"
     gene            64398..65597
                     /locus_tag="KRO40_000625"
     CDS             64398..65597
                     /locus_tag="KRO40_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091464.1"
                     /translation="MKLKSKISILIIFLTLAIYFSIGLLNNEDNLKIKTIKGDSNELD
                     HININFGYALNGYINSYYTINGSNKTKKTELIKLQKDSKNTNNLIDVSSGSDLIAHVG
                     FEMNEESKDINFVIDEKKEDLEKGVFPSEGSDKEIEYEKLDMNNFTRTRYKVDKSTDD
                     YYANILASKRYKKYLYVSVLYATSDSSENNKEYSSTIDIIKINPENKKIKTIKSINLS
                     NYFSEKYQNIETIGVSYASKYEDKMYILVNVLNTNIGDNSNSKFHLLEYNLEENKESI
                     MELKTDSKMALAKAKLEANKLYMVMSNDYDNSSITELNLLTYNILDKSLDEDKYVLDN
                     REKRGIRSIEIDSNKIVAYTSRLNSILSWDNKFMLYIINKNSKEIVYEGELQFNSSNS
                     MLEFEIK"
     gene            65606..66418
                     /locus_tag="KRO40_000626"
     CDS             65606..66418
                     /locus_tag="KRO40_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091465.1"
                     /translation="MKDLIRLFEFELKRNIKNYIFIIICCCSFVILNIVKNLNDYNYI
                     IENAVKSEQLTKIGNTIETVKVTGFSSFRNIMGSTESWFMFGIIACICYAFFIWYRDF
                     NGRSKSIYTLIMLPKNRINIYISKLLNILFLVYSYTVVLTISLFIASKLLPRHMLGNV
                     TNYGFVQETIYELKMLLPYSFEILFVEYIFLLIGFVSVVFTSILINKSIYKVSTLISF
                     LFLVIEILVFIISIEFIIPYEYSDVFTVLYSSINIFVCSLISNKLLKQKIDF"
     gene            66429..>67187
                     /locus_tag="KRO40_000627"
     CDS             66429..>67187
                     /locus_tag="KRO40_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091466.1"
                     /translation="MKAKNIGKYTICFIIVCFLMITMTLILSYFNKDKLSVKTLKGNV
                     KDIGRVSVVYTPNISKFSYEEVIISKNGVRNNTNPKSRIRNDYLNIDKKYSDFVNDKG
                     KEFIYKDDLNIGEAYTSVKSDLVQGMNALNDCIKVSNKNLKSGVEENFDINLNKSDFK
                     ENSWKTLFNKIYKGNLYMVISETNISGSKVNNICILKIDIKNKSYKLLNRFNLGLQNG
                     EQQNINEIKFSIGSKLYLEIVNNKSKNGYIEGHDS"
BASE COUNT        25978 a         7394 c        11733 g        22082 t
ORIGIN      
        1 gtttttataa tttttttata tttaaacata actaaaaata aaagattact aaagctaagt
       61 agagtttatt ttattttaat aaataataaa gctatttttc tatatattgg cataatatat
      121 gcttatttaa ctatgaaatt aaaattaaat aggattaatg aggaggaaaa aaatgggaag
      181 taatgaacta aaaaagactc ttggcgtatc agcagcatta tcaactgttg ttggttccgt
      241 tataggagcg ggcgtatttt ttaaaccaca agcagtctat acattaactg gaggagctcc
      301 aggtcttggt atattggcat ggttaatagc tggaatcata actataacag ctggtcttac
      361 agctgcagag gtatcagttg cgataccaaa aactggtgga atgatggtat atataaaaga
      421 aatttatgga gaaaaattag gttttttaac tggatggatg caaattgtat tattttatcc
      481 agggatgatg gcagcattag gtgttatatt tggagaacaa gcatcagcac taattggtag
      541 tccatcactt ttacttccaa tagcaattgg aattatagta atagttgcag ggcttaatat
      601 gttaggttca aaaactggag gagtcataca aactgtttct acaatttgta agttaatacc
      661 acttatttta ataatggttg ttggatttat taaaggtggt ggaaataatc caatacttac
      721 acctatggtt ggtgaaggat taagcctggg tagtgtacta ggtcaagttt taattgctat
      781 attatttgct tttgatggat ggatgaatgt tggtacttta gctggagaaa tgaagaatcc
      841 tggaaaagac cttccaaaag ctataatagg tgggttgtca gttgttatgg ctgtttattt
      901 tataataaat ttagcatatc tttgggtatt accagctaat gaattagcaa attatgcttc
      961 tcctgcatca gcagttgctg aagttatatt tggttcaatg ggtggaaaaa taatatctgt
     1021 aggtatatta atttcagtgt ttggagcatt aaatggattt ttactaactg gttcaagggt
     1081 ggcatatact ttagctacag ataagacttt accaaagtat ggtatatttt ctaaattaaa
     1141 ttctgctcaa gttccagcaa atgcaatagc attagtatct gttattgcat ctatatatgc
     1201 tttgtcaggt caatttaatt tattaactga cttagctgta tttgctactt ggatattcta
     1261 tgtattaact tttatagggg ttatgaaact tagaaagact catccaaata taccaagaga
     1321 gtataaagtt ccattatatc ctattgttcc tataatagct atagcaagtg gtatatttgt
     1381 tgtagttaat caattgtgtt ttgcaggtat gaaaactact atgatatcta taggaggtct
     1441 tgtaataaca gctataggct taccagtgta tgcttatatg actagaggag taaaaagata
     1501 aaccaagtag tttacaaatg cttcataatt aaaataaaag agactgtctc aaatagagat
     1561 aagtctcttt tttattgtta aaatggtaaa gatatgtttg attttacaaa aaaagagcgt
     1621 tccatgaact aaaaagttta ttttaaggta ttcattttat ttttagtttt ttgattataa
     1681 aattaaacat ctaaaaaatt atttatttta aaatacttta ttttaaagtg ttttttatca
     1741 aactaagtgg tatctgtaca acaaatatta tacatagctt ttatgaaaat taaatctttc
     1801 tgttatatat aatagaatat tgtattatat agaaaatatt acctgattaa tatagtgatt
     1861 tataaatgag attagaaaat tttatttgat aacaaaaatt agatagtatg aatatataat
     1921 gtatgtatta aaaatgtggc aaatagttgt tttgctattt attatttgtt taatatttct
     1981 aatttataaa aaaaaaatta taaattttaa aaattataaa tgacatttta actagaatta
     2041 attgtaaaaa acactatata atactcaatt ttcaacattc tatacaatta tacagaaatt
     2101 atacagcata ataatcaccg aaataacaaa ttttaaaaat taagcaaaac tttttgtcga
     2161 agttcaacgt ctatatatat gtagtgtaaa tttttgggat aaaatactac aaaaatataa
     2221 atgtaaaaat atagtaatat tggaggtcga acgatgagaa ataaaaagaa aaaaataaat
     2281 agaaagaagt tgtatttgct tttaagtgct attgtagtgt gtctggcttt tatagtagtt
     2341 ggtgttcgcg tcagctcttt aaatatgaag gaaaatgaaa ttagtagaaa tgcaaaactg
     2401 tcaagttcta ctattacaga tatagtatct aatacatcaa tagaagttag taaagggcca
     2461 agtaaaagtt ctggaaaaat agcatacata actatagatg atggtccatc taaatttact
     2521 gacgagatga taaaaacttt aaataaatac aatgttaaag caactttttt tatgatagat
     2581 gggaatatga aggaatatcc acagcaagtt aaaaatataa ttaaaaatgg gaacacagca
     2641 ggttttcata gtgtatcaca tgatattcac aagctttatg ttactagtac atcagcaaaa
     2701 gaggaatttg atacaaatga tcaaactttt tataagataa ctggtaaaca ttcaaaagta
     2761 ataagaatac cttatggaag caaaccatat acaccacaag cctcttatca ggctttagtt
     2821 gatgctggat ataaaatttg ggactgggac ttagatacag aagactggag atctaattct
     2881 tctcaaattg tacaaaatgt aaaaaatcat attaagaata gaaaaggtga agataaagac
     2941 caacttgtag ttttaatgca tgagaaaaaa cagagtgcag aagctttaga ttcagtttta
     3001 aaattcttat cagatgaagg ttatgaattt gcgccagtag atcaaaacca aataccaaaa
     3061 aattattggt tacgtaattt agagtagtta aaatataaga atattgattg atatttttag
     3121 aaattgagaa taaaaatgag tgaggtgtag gtatattgaa taaaaaactt tatataggaa
     3181 tggtcggaat attgtctttg atgatggttg gttgtaataa aagtttagca aaagtaaatg
     3241 atgtggaaat cacaaaagaa cagtacaaaa aaacaaaagc agttttatct gctactaata
     3301 attatataaa tgggcagtct ttagatgaat tagaaaaaac tttggataaa aaaggtagaa
     3361 ataaattaga aaatgttata atatcgttta tggtggataa tgaactttta tatcaagagg
     3421 ctaaggataa aggactaact ccaagtaaaa gtgaagtaga ctcaaaatat caagaactag
     3481 aagataagat gaatttgaat acaagctata aggaaaaaat ggacaaagca ggtgttgata
     3541 aagattattt aaaacaagaa atatctagag atttagcaat agataaaaat aaaaaggcct
     3601 ttgaagatag aataaacata agtgataatg atatggaagc ctactataca agtcataaaa
     3661 aagattttaa tgtagaagaa gtaagtgctt ctcagatact tatatcgact ttagataaaa
     3721 ataaaaaaga agtaagcaaa gataaaaaag aagctttgaa gaagaaggca gataatatat
     3781 tgactaaaat caaaaatgga gaaagttttg aaagtttggc taaaaaatat tcggatgata
     3841 aagcaactgg aaaaaatgga ggacagctag gatattttac aaaggatgat aaaaatgctg
     3901 agtttacaaa ggaagtgttc aaattaaaga aaaatgaagt ttcaaatgtg tttgaaacta
     3961 gttatggata tcatatagtc aaagttactg ataaaagaga aagacaaaaa agttttaatg
     4021 agtgtcagag tttaataaga gaatctattt taaatgaaaa gtatattgag catataaaaa
     4081 aactgaatga agatgctaaa atagacagat agaatttcta acagctcaat cctagcctgt
     4141 aatcggaggg agattttaca ggaatgttta agagtttaaa gagaacgaaa gttgagaaat
     4201 acattatcga taataaagac tctttttata gaatagcata tagttatacg aagaatgaag
     4261 aagatgcctt agatgtggtt caagaagcca tgtataaggc actatactca gtggaaaata
     4321 ttaaagaagt aaattatata aagacatggt tttataaaat tttagttaga acgagtatag
     4381 attttattag aaaaaaccgt aaatataata atatgacaga tattgacctt atagatgaga
     4441 ctggagagta tgataaatat actgatttgg atttaagaag agctttggaa gaattaccta
     4501 ttgaatacaa atctattata atattaagat tttttgaaga tttaaagatt gaagaagtag
     4561 caataatatt ggatgaaaat gtgaatactg ttaaaactag gttatatact gctttaaaaa
     4621 aactaaaatt aaaaattgaa gagtagggat aaaaagaatg acaagcaaag aaaggttaaa
     4681 taagttaaaa gatgagtatc ataaaattcc aatacccaag aaattagata ctataataaa
     4741 tcatgaaaaa atagaaaaca tatatcgaga gaaaaataaa aaagtaaata gattaagatt
     4801 taaagttgca atagcctttg catgtatatt tacagtatta gtaaatataa gtcctgtatt
     4861 tgcagacaat ttttctaaga tacctgtaat tggagcaata gtagaagtaa taactataaa
     4921 aaattatagt ttaaaaagtg aaaattatga agctgagatt gatattccta aaatacgagg
     4981 tttaaaagat aaaaacttag aacaaagatt aaacagtagt tttatggaag atggaaaaag
     5041 gctttatcat caattccaag agagaatgga gaagatacaa tcatcaaaga ataaaggata
     5101 taaatcttta agtttgagtt atagtgtaaa aaataattct aaaaaatttc tatcaataga
     5161 gatgacaaaa aatgagatag aggcttcatc atatgtgagt aaggtacatt atactattga
     5221 taaaaaaaga caaatagttt tgactttgcc aatgcttttt aaagatgata agtatataaa
     5281 agttataagt gataatataa aagaacaaat gagagaacaa atgaaaaagg atagtacaaa
     5341 atcctatttt atagatcaaa aaaaagattt gcctgttgaa gattttaaaa caattaataa
     5401 gtatcaggat ttttatttta ataaaaatga agaccttgta atttgttttg atgaatatga
     5461 agtagcacct ggttatatgg gtgcagttga gtttgtaata ccatataaag taataaaaga
     5521 tttgtaaatt gaatagtagt ttatatataa atattttaag aaggacaata tgactacata
     5581 taaaaagctt aaaaaatcta tatttaaaat tgctatattt tcaatatgct tattagtttc
     5641 attagtagat acaaacccta tatttgcagg tagttccttt aatgaaactt caaatagtga
     5701 tacgataaag gtgttaaata ctaagagtat caactttaaa caagacaatt atgaagtgaa
     5761 tgtgagtatt cctaaaataa aaggtttaaa agataaaact ttagagaata aattaaacaa
     5821 tgagtttttg caagatggga aaaaaattta cagtgaattt caaaataaaa tgaaaaagga
     5881 agataataag ggtcatagat acctaaatgt aatccacaat gtcaaaaata attctaagga
     5941 ctttttatca atagaaatga caaaagaaga gatagaagct tcctcatcta taactaagaa
     6001 gcattacact gttgataaaa atagaggaat actattaaat ttaccaatat tttttaaaga
     6061 tagtagatat attagagcta taagtgataa tataaaagag cagatgagaa atcaaattaa
     6121 gaaagatgat acaaaatctt attttataga ccaagataaa gactcgccag tgaaagattt
     6181 tgaatctata aataagtatc aagattttta ttttaataaa aatggaaatc ttgtgattag
     6241 ttttgatgaa tatgaagtag cacctggtta tatgggagca gtagaatttg tgataccaaa
     6301 taaagtaata aaaagactaa gatagatata tagaagattt ttagatagac tggtaaggag
     6361 aattatatga atatatatga acaagcaata agattaatag aaaataatga ggatttcgca
     6421 tttgctacaa taacgtctca ttcaggttca acaccacgtg aaactggagc aatgatgatt
     6481 gtgaaaaatg attctactat atttggctca gtaggaggag gtagtgtaga agcagaatgt
     6541 ataaaacatg caattaatgt tataaaaaac agagaatcaa tgttgtataa atttactcta
     6601 aacaaatctg atgtggcaaa actaggaatg atatgtggag gtactggaga aatacaaata
     6661 gattttatag atagtaaatt aaaaagtaat atagaaaaat ttaataagag actaaaggaa
     6721 aatacaagta aagcatatat atttggtgca ggtcatattt caagagatgt tgctgtgata
     6781 ctatctcttt tagaatttag aacagtagta atagatgata gagaagaatt tgctaatcat
     6841 gaaaggtttc cagaatcaga agtagtagtt ttagattctt ttgaaaacat accagatttt
     6901 ccaactgaca aaaatagtta tataattatt ttaacaagag gtcatctata tgattcaagt
     6961 gctttagaat gggctcttaa aagagaggct ggttatatag gtatgattgg aagtagaaca
     7021 aaaattggat tgacttacga aaaactcatg aaaaaaggtt ttaagaagga agaattatca
     7081 aaagtacatg caccaatagg cataaaattg aatgctcaaa caccagctga aatagctgta
     7141 tgtatagctg ctgaacttat aaattgtaga gctaataagg aaaaataaac taatgaacac
     7201 agggagtaaa gatattgata ctttaaaggt taattttaga gggattgaaa taaaagcagt
     7261 tttagtatat aaaaatagaa aaaatatttc tataaaaata gatccatttg gcaaaataac
     7321 tgtaatgagt cctcctaaaa tatccaaaaa aataataaaa gatataatta ttgaaaaagg
     7381 agactggata cttaaaaagt cagaaaaatg taaaggaaga gaggaagtat ataaacaaag
     7441 aatgtttata actggcgaaa aatttcttta tttaggtgaa gagtaccatt tagttataaa
     7501 agaactgttg agagattctg tcaaaaaaag taactgtaga ataactatta acgaatatca
     7561 aatagttgtt cagacaaatg atacaagtac agattttatt aaaaaatctt taaaatcttg
     7621 gtataagatg gaaagtgaaa gaatagtatt agagagaata gattttctta aattaaattg
     7681 tgaaataatg aagcaattag ttccagcgag tgttaaggta aaagaacaaa ataagagatg
     7741 gggaagttgt acagctcaaa aaaatattta tataaactca aaaatatcta tggcaagatt
     7801 agatgtaatt gattatgtaa taatacatga gtttagccat ttagtacata tgaatcactc
     7861 taaaaaattc tatgatttag taaaatccat tatgcccgat tataaagata aagaaaattg
     7921 gctaaaaata aatggatata aaataataat ctgaaaacga ttattccaaa atataggcgt
     7981 aaagtataaa agaagtatta ttgtgaaaaa aataaataat ctgaaaattt taaaaaaagt
     8041 cattgacatt gtaaatgata gggaatataa tctatattaa caacaaaaca gaattaaaat
     8101 ataaaattaa aaaattaaaa gcaatgacag agacaacaat actaatagtg ttatccacag
     8161 agaaccaatg ttgctgagaa ttggtgttaa cagtagtata atgatcactc tggagctttt
     8221 gtactgaata tttttagtaa gtacaaacgt atgtcagcgt tacatgacta aggttaaggt
     8281 aattaattac ccgacctgaa aaaagagggg tagatgtatt ttttatatct acaaataagg
     8341 tggtaccgcg gaatataact ttcgtcctta taagtaatat ttatattgct tataaagatg
     8401 aaagtttttt tattttaagc gatataaata aatttaatcc atataaaatt aataaaaaaa
     8461 taataaaaat aaggagggat ttttatggaa aatactgtat atgctaaatt aaaccaagga
     8521 atagattctt ttttaagagt ggctatgact ctaagaagaa gagaggttga tatacaatca
     8581 ataagtatga ctgtagataa tatgaataat tcaggtataa aattaatagt aaatgaagaa
     8641 aagacatcct tagattctgt cttaaaccat atgaaaaaac tacatgatat aagagagata
     8701 actgttgaaa gaatgagaca ttaattaaat atattttata aagctaaaga taaatatgct
     8761 tattttaaaa taaaaaacta aagataaata ttaaataaga aaaatcttag attaaaatat
     8821 aagtgtcatt gaatttatta gtttatcaca gttaataaat ttattagttt gttgtagcta
     8881 ataaaaactg aaaattctaa aattataatt gtaagattat ataaatttag aatttaaatc
     8941 tgttgaataa tattaaaaca atgataatga gtatgaattt ctaataaaaa taaatatcat
     9001 aaaaataaga aaaagtattg ggaggaaatg aaaatggcaa gaatgtatta tgaaaaagat
     9061 gtggatttag aagttttaaa aaataaaaag gttgcagttt taggttatgg aagtcaagga
     9121 catgcacatg cacaaaatct tagagataac ggtgtacatg tagtgatagg tctttatgac
     9181 ggaagtaaat cagcacaaaa agcaaaagaa gatggatttg aagttaagag tgtagcagaa
     9241 gctacaaaag aaagtgattt gacaatgatg ttaatgcctg atgaaaaaca aaagaaagtt
     9301 tatgaagaga gtgtaaagga taacttaaaa gaaggccaga cattagcttt tgctcatgga
     9361 ttcaatatac attataatca agtacaacca ccagaatttg ttgatgttgt aatggtagct
     9421 cctaaaggac ctggtcactt agttagaaat gtatttacaa agggaagtgg agttcctgca
     9481 ctatttgcag tatatcaaga ctacactaaa aaagctacag agacagtttt agcatatgca
     9541 aaagggatag gagcaacaag agcaggtgtt ttagaaacta cttttaaaga agaaacagaa
     9601 acagatttat ttggagaaca atcagtactt tgtggtggaa taagtgaact tataaaattg
     9661 ggatataaaa cgcttgtaga tgcaggttat caaaaagaag tagcatattt tgaatgttta
     9721 catgaaatga aactaatagt cgaccttata tatgaaggtg gatttgaaag aatgagatat
     9781 agtataagtg acacagcaga atatggagat tatgtatctg gtaaaagggt aataactgat
     9841 gttgcaaaac aaggtatgca aaatgtttta gaggatatac aaaatggaaa atttgcaaaa
     9901 gcgtggatta aagaaaatga agaaggacgt gaaaacttcc taaaaactag agaagaagaa
     9961 tataatacag aaattgccga agttggtaga aatctaagaa gtatgatgtc attcttaaaa
    10021 taaatatata ttaaatggat tagtttgagg gaaagagtgg tgtatagtag tgcgtatgaa
    10081 tggagcaaag gtaattttag aatgtttaaa gaaagaggga attgacacaa tatttggata
    10141 tcctggtgga gccgtgatac ctctttatga tgctctatac gattattcag atgattttaa
    10201 acatataagg acatcccatg aacaaggttt agttcatgct gcagatgggt acgcaagaag
    10261 tactaataca gtaggagttt gttttacaac atctggtcca ggagcaacaa atgccataac
    10321 tggaatagca acagctttta tggattcttc acctatggtt gtaatttcag ggcaggtgcc
    10381 aactagttta ttaggaaaag attcttttca agaaattgac ataactggag caacattatc
    10441 tatgacaaaa cataattatt tagttagaaa cactaaagaa ttagttccta caataaaaga
    10501 agcttttaga gttgcaaatt caggtagaaa aggacctgta cttgtagatg ttccaaaaga
    10561 tttattttta gcagaaatgg attttagtgg tgaggactat gatttatgtc aaatagatga
    10621 ttatatggat tataagagtg attttgatct agatgatgaa actaatatta agcttttaaa
    10681 tgaagcaata gatatcataa aagaatctaa aaagcctata atatatgcag gtggaggtgt
    10741 taaatcttca gacagtgagg aaattcttga aaaatttgca actaagatag atacacccgt
    10801 actaaataca cttatggggc ttggaaatat agatagaaag aatgaattat ctcttggaat
    10861 ggttggaatg catggaagta gagaaagtaa tttagcactt tctaattcag atttagtaat
    10921 agcgataggt gcgagattta gtgatagagt gataagtaaa agttctgaat ttgctaaaaa
    10981 tgcaaaaata atacacatag acatagaccc atctgaaata agtaaaaata tagaatctaa
    11041 tgtatctttg gttggagatg taaagctagt ccttagttta ttaattgaaa gggttgaaag
    11101 taagaataat agcaattgga aagaagagat aaagagattt agaaagagtg agggtgtaca
    11161 aacatatgaa tttcatccac aaaatatact taaaaaaata aatgaaaaat atgaaacatt
    11221 aaagaaaccc actgtggtag taactgatgt cggtcaacat caaatgtggg ctgctaagta
    11281 ctggaatttt aaaggtaata aaagttttat aacatcagca gggttaggaa ctatgggatt
    11341 tggtttaggt gcagctattg gaactaaagt tggtaatgta gataaaaatg tggttttagt
    11401 cactggtgat ggaagtttta gaatgaactg taatgaacta gctacagttg caaattataa
    11461 tgtacctatg cttattttac tactcaataa tagaacatta ggaatggtaa ggcaatggca
    11521 aaagttattt tccaatcaaa gatactctca aactgacatt aatgaaaatg tggattatgt
    11581 taaactcgta aatgcatata acattgatgg atataaggta tccagtatgg aagaattagg
    11641 aaaggcgcta gatatgatag attttaataa accagtattt ttgcaatgtg atatagataa
    11701 ggattatgat gtttatccta ttgtagcacc taatgatgca ttggaaaatt tgatatgtaa
    11761 ctaaaactta tactgaatat tgataaaatt ttttattaaa tttttattag tattcagttt
    11821 ttgttgttta gagatagatt ggcatttttt atttttgcaa ataaatcaat gactatataa
    11881 ttaagaactt attaaatttt aattatacaa tttagaatag tattacaact taagtaaata
    11941 ataattttga ataataattt acggaggtat tcatatgttt aaacacgata aagcattatt
    12001 aaaagaagta aaagtagaaa gaccaaatcc tcaatatgct gttttaatgc aagaacagtt
    12061 gggtggtgca aatggagagt taaaagcagc tatgcaatac ttgtcccaaa gttttagaat
    12121 aaaagaccct caaataaaag atttatttct tgatatagca gcagaagagc ttagccatat
    12181 ggaaatggta gcacaaacta taaatttatt aaatggacat gatgttgatt ataatgcagt
    12241 taatacaggc gaaatagaaa cacatgtatt aactggtcta tcaccagtct taataaactc
    12301 atcaggagct ccttggactg ctaattacgt tacagttaca ggggatttag tagctgactt
    12361 actttcaaat atagcttctg aacaaagagc taaggtagtt tatgagtact tgtatagaca
    12421 aatagatgat aaatatgtaa aagaaacaat agatttctta cttaatagag aagaagcaca
    12481 taatgctcta tttagagatg ctttaaataa agttaaagat acaggttcaa atagagattt
    12541 tggagttaca gaagattcta aattatattt cgatttgtct actccagggc caaatcacga
    12601 tactaagata gatattaatc ctccttcttt tgaaaaacct ttaaaaaaat aatttgatat
    12661 tttttatgtt gttttgtttt agtagttata aaaattattt actagaagaa ttaattatat
    12721 gaaaaattaa atatgtatag ttaaaaatgg gtatacactt attataagtg tatatctatt
    12781 tgtttattgc aaaacatata ataaaataac aaatgaggtg gtattttgga cagtaataga
    12841 aaacctaata acctaataaa tgaaaaatct ccatatcttt tacagcatgc ttataatcct
    12901 ataaactggt atagttggaa tgatgaggct tttaaaaaag caaaagaaga ggataaacca
    12961 atatttttaa gtgtaggata ttcaacatgt cattggtgcc atgttatgga aaaagaatct
    13021 tttgaagatg aagaagttgc tgaaataatg aatagaaact ttgtggcaat aaaagtagat
    13081 aaagaggaaa gacctgatgt agatagcgtg tatatgacag tttgccaagc tatgacaggt
    13141 agtggtggat ggccaatgac cataataatg acaccagata aaaaaccttt ttttgcggga
    13201 acatatttcc caaaatattc aaggtataat aggcctggag ttatagattt attagagaat
    13261 gtatctgaaa agtggaatac aagcagggat atattaataa aatctggaga tgaaataata
    13321 gaagctctta aggatgattt tggtgtaaaa aatactgagg gtgatttatc aaaagagatg
    13381 ttgagttcat cagttagagt atttaaggct atttatgatg aaaagtatgg tggttttggt
    13441 aatgctccta aatttccaag tcctcagaat cttatgtttt taatgaaata ttatagtata
    13501 gaaaaagaca aagatgtgtt aaaaatggtg gaaaaaactt tagatggaat gtatagagga
    13561 ggcttgtttg atcatattgg atttgggttt tcaagatact ctactgataa aaagtggttg
    13621 gctcctcatt ttgaaaaaat gctatatgat aatgctatgc ttactatagc ttttttagat
    13681 gcgtataaaa taacaaagaa agagttgtat aaagaaattg ctataaaaac tatagattat
    13741 gtagttagag agatgaagga taaagaaggt gggttttatt cagcacagga tgctgatagt
    13801 gaaggtgaag aaggtaaatt ttatacattt aatcctcttg agataattga agttttgggt
    13861 gaagaagatg gaactttctt taataattat tttgatataa ctagtagtgg aaattttgaa
    13921 ggcaaaagta ttcctaatct tataaaaaat aaagaatatg agagacataa tgaaaagata
    13981 gctgacctta gtaaaaaggt atttgaatat agaaaagaaa gaacatcttt gcataaagat
    14041 gacaagatac ttacatcatg gaatgcattg atgatagttg ctttaacaaa ggcatatagt
    14101 actttaaaaa atgacatata tttagagtat tcaaataagt gtcttaactt tataaataat
    14161 aatcttgtaa atgagtcagg tagattatta gctagatata gagatggaag ttccgactat
    14221 ttagcatatt tagatgatta tgctttttta atctgggcgt atatagagct ttatgagtca
    14281 acatttaata tgaaatattt agaaaaggct ttaaatttga atgaaagctg tatcaacctt
    14341 ttttgggatt atgaaaaaag tggattttat atatatggta aagatagtga aaatttaata
    14401 gcaagaccaa aagatttgta tgatggagct attccatcag gaaattctgt tcaattatac
    14461 aatcttataa gacttgcgaa aattactgga gataatagac ttgaagaaat gtcatataaa
    14521 caattaaaac tgtatgtgga taatgtaaag agttctccaa ctggctacag cttttatatg
    14581 ctttcattga tgtttgaact ttattctact aaggaaatta tatgtatttt taaggaagat
    14641 tctgatttaa ttgcatttaa agaattgata agtgaaaatt ttataccaaa tgcaactttt
    14701 ttagcaaaga aatacaatga agaaaacact attataggtt ttttaaataa ctatagattg
    14761 aaggatgata agattagtta ttacgtgtgt caaagtaata gttgtagtca accaattaat
    14821 gatttacaaa aattaaaaga tatgatttta ggagtagaat aatcataata gcgaaaaagg
    14881 agatgcttta aaataaaagt ctaatcatct cctttttttg tacaaaaaac agaaaaagag
    14941 ttcctaagaa cacctaatct atgtaatgat tgttttgtta aaaaataaaa atgacattat
    15001 agttatataa aatattgtac tataaaaaag tggtattata gatgcgatag tattaatctt
    15061 ttttatttac tctatttctt ctttttgcaa attcttcaag tgcttcagat ttaattttat
    15121 ctatttcttc atattccata aaattagcat cttcttcaaa gccatcttgt tcttcaccat
    15181 taaaacgata catttttttt agtaaactcc ataaggtctc taattcatct ttggtaaatt
    15241 cgtgaaatac atctgccata aagtttattc cagtcctact acatgtcacc ataacctttt
    15301 ttcctaagtc tgtaacttta acattaattg ctctcttatc atgaggactt ggaattacat
    15361 caacatatcc atttttttca agattagcaa ctagtctatt tatattttgt ttacttgtac
    15421 ccatttttct tgcaatatta tttaatgttg tttcttcctc tggtaaatga agaattgata
    15481 aaatagtcat atactgtctt gaagtaagta taccaaaata tttatctcct tctatttgta
    15541 ttttgtttgt aagggtaaaa agagttgcat atgtttgatt cattaaaaag agctctttta
    15601 gttcatttga ataatccatg aaatatatct cctttatttt tagatgttgt tttgtcgaaa
    15661 acagaatatc atgaattaat tctaatgtca atatggtgtc aaaatatatt aaagtattac
    15721 ttttttatgt aactattaat taagagataa attatatatg tctttttgac tatcttttta
    15781 tatcttctta aatgtccgca aagccttatt ttataggctc tacgggcatt tttcttttgt
    15841 ggtaaacctc acatatctag gtctatcttc ttatattttc gctatcaagc gtggttaaaa
    15901 tcgtggtaaa tacttctatg cgattagacg ctgaacctct gattttgcag tatctatgga
    15961 cgcatgagca taccagttca ttgtgatact gatatttgaa tgtcccatga tatactgtaa
    16021 atcttttggg ttcatgttct tgcttgccag ccttgtgcag aacgtatggc gtagcgtatg
    16081 cggtgtgata tgtggcaagg ggttatcctt atggtgcttg ttgtatttct ttaccatacg
    16141 gacaaataag gcgttataat caatggcaac tttgggcttg cctttctgat tgacaaatag
    16201 aaagttgccc cgtccgtcta tcacaaatgg ttctgccttt gggcgtttct tcatcactcg
    16261 ttgaaatgct tgtatcgttt ctttgcttaa tggcacttgc cttgttccac tctttgtctt
    16321 aggcgtttca atataatagc cctgttcctt gctctttaat aactggtggt cgataatcac
    16381 aacctcattc ttgaaatcaa tgtcggctac tgtcagtccg cacagttccg agatacgaag
    16441 tcctgttttt aacagtatca gcacatcatc ataatacttg tgatacacgt tgtccgtctt
    16501 gatgaatgac agtagggctt gttcctgttc ctctgtcaat gcgactttct ctttggtatc
    16561 attttctagg acttcactca acttgaaatc aaaagggttc ttccttacac aatcgtcttg
    16621 tatggcgata tagaatgacg cttttaacga gcgtttatgg ttgttaatgg tgttatagga
    16681 aaagcctttg tctttcatgc gtaacgccca ttccttagcg tcagagggtt ttatcgtatc
    16741 aatgctccta gcacctaact tgtcctcttt caataaccgc atgagctgtt cccgttgttt
    16801 ctgtgtgctt ttcttcacat ttgccctctg tgtgttctgt ttggcataaa gttggcaaag
    16861 tgtcattttc ttgcctgtgc tgtcgatacc gtcctcaata tcccgtctta tctgctgttc
    16921 cagttcacga agtgagggtt tttcccgttt tccctttggt gtcgggtctg tgggtgtcaa
    16981 tctccaagca tacacatatt ttgtgttccc aaatgcgtcc acatatttat ataagtattt
    17041 cccgtctgtt cgttggctct ctccagtatg caggatacgt cctttgctat cccgtctttt
    17101 ttctttcatg gtgtctgctc ctttccttgt tggaaagagc cttgatatga cttgtgttca
    17161 tcataacaca tacaaggctc atttgcatta gattgcgtcc aatttatcaa taacctgttc
    17221 aaactgtcgg cgtttaatct gtatgcggtt gccattcata atgagccagc cagcgtcctt
    17281 gttttcctct gccaagcgtc ttaacttgtt ttctccgata cggaaatact ttgatgcttc
    17341 ttcaatggta agggtgtatt tttcccatac gggaatatcg ttgttattca tcagataccc
    17401 cctttcccat gtttggtgtc atactggata taggggataa ggtcggtgcg gtttatcctc
    17461 tgtaaatggg cggttaattt actggaaagg gaattgctgt atcttgcctt atcaagcata
    17521 gttcccactt tttccagtcc acctaatgcg ttatgttctt ccaagaagta aaaacttttg
    17581 acagcggaaa tcacgccacc ctctgtgagc cactgctgtg tttcctcaag ggaattttgt
    17641 tgttttggta cttgcagttt taagacttcc acagccccta aaaagcgttc ccaaaaccga
    17701 cacgttttcc atctgctctt attactttcg tttctgtttg gtacgacaaa gcgtaggtta
    17761 tttgccaata gtccgaaagc cagttctcca agttccagcg gtctgtcctt gaatgtcatg
    17821 gcaaaggcat gagccttatc atcacgcagt tgcatttctg tccgtttcca actgccgact
    17881 tcatcaagcg tcttattatg ttttgaacag acttccttat ccttgtcata aaagcggtag
    17941 gacaatcccg atttaccagc accgatataa acagtctttg cggtgtcgaa atcatcaaac
    18001 ttgctttcgt caaagtgata gccctcacta ttcgagataa attcctcctt ttcgcatttc
    18061 ttctttatct gctctatggt aaagaatggc ttttcgttct tatcatcaat ggcaatatca
    18121 agtcttgtga aatggaaatt atccagtccg tatcttcgct cacagcgtcg gaacatatcc
    18181 ccaaaggtat aattcctact gtcgagaata cggaaaatat catcacaacc tctgccggtc
    18241 ataacaagat aacagcctaa cccttgtggg ttatcctctg tctttcttgc gtcccccgat
    18301 acataaatat ctccaatctg ccagcgtgct tgataggttt tgtatttaac gcttgccgga
    18361 taaacattga aaatgtcagt cggtaaacct aaaatgtgca tgatgacatc ttcggcggtt
    18421 gcagtatcga atacaatact gatgtaatca atcttaacgg ataaattttt gtgtgtagtt
    18481 atagtgcatt actcctttcg tacttcccgt ttttttgcgg ggtaaaaatc gtgttttttc
    18541 ctttatttat cacagtttct aggtactatg acatgtatgc gcagggcggt gttacatata
    18601 cgccctttac gaacgcctaa cggcgttccc tttccaaaag gaactgtctg tccgaacacg
    18661 tctgggggac gtgccccgtc cagccagccc cttttggaaa ccactatttt cggtctgata
    18721 gtccatgctt attcatgcta tcaaaatgaa aatacatctt tcctatgctt actcaagcgt
    18781 gtgattgacc ctagcgtgct taatcaccct atctaatacg ataataacgc tattagaatt
    18841 acttgtcaag aagtttttgt tgacttttag atatatatta agtatgatat gcttataaat
    18901 actaagaaaa gcaacgaaag gagcggttat actaagttat ggagcattac gaaaagaaaa
    18961 tcagtttctt aggagaaaac atacagacca taagaaaaca caggggaatg aaacaacagg
    19021 aacttgcgga caaaatcggt atcaatatgc agagcctttc caaaattgaa cgaggtgtga
    19081 attatcctac ctttgatacg ttagagaaga taatggacgt gctgggtgta acgcccaatg
    19141 aattattgtc gggagaatgg aagtatattg accacaccga gccatatatc atggatatta
    19201 tcaaacggga acaagacttc aatgtttcct tagattatct gtctgaaaat gaatttttca
    19261 atgacgaaaa agaatgtaga ttttacaagg aatataaact catacagtat attcataact
    19321 acattaccaa tgaggttacg gagttggaag aacttatgga aatcaagcag ttaatacaac
    19381 gtcaaaaaat agaacgcatg atgaaagtac ataaggaaat gcgagggtta gaccgataca
    19441 gagaacagcc caaagagtat aaataccatg acccttatga tgattggata ttccgtcagc
    19501 ttgcagatat agataacaga aacaacattc ccgacacttc tccgcaatta gatttcaatg
    19561 aggcggacta tgaagattat ctaaaggcaa aatggaacag aggtctttaa tttcctcttg
    19621 catggaagat acagtaaaca aaaagcccag taaagagtgc aaagcaccac caatggtggc
    19681 aaggctcttg acagggcttt tccttttctg tggtgggtaa tcaagaggaa gaaagaaaaa
    19741 gtgtgtagtc caatgcagaa aatatttaaa gggtatgttg atttttgttg tgatggatat
    19801 atggaactgc tataatatgg ttatgaagaa aaagataaat taaaaattca aggagaaact
    19861 aaaatgattg tattttggat aatcggaatt ttgtttttaa tcgtaggctt aatagttagt
    19921 gttcctacaa ttattaaatt catcaaatgc aaggaacata caacgggtaa aattgtaagt
    19981 attgatagtt catcaaatgg atatgccaga gcagtatatg aatatattgt atctagcagc
    20041 aaatatacaa ataaaacaaa ctggactcca catcatatat ttcatcttga tggagagtgt
    20101 catgttattt atgataagaa taatccaaat tcttcttata tcaagaaaag tggacaatat
    20161 attcgttgta ttgtaggtat actttttgca atgattggaa taggtgtatt gttactgggg
    20221 atatttctta ttactgtttt atagcggtac aatgcttttt gctttgatga ttttttagaa
    20281 agtgcgaggt acttatttat gaaaaagaaa aattttttat ttatagttgc aatgctttaa
    20341 tgaggcagac tatgaagatt atctaaaggc gaaatggaac agaggtcttt aatttcctct
    20401 tgcatggaag atacagcaaa taaaaagccc agtaaagagt gcaaagcacc accaatggtg
    20461 gcaaggctct tgacagggct ttttcttttc tgttgtaggg taatcaagag gagaaagaaa
    20521 aagtgtgcat ttttgttcca tagaaaaatg ctaagggtat gctgattttt attgtggcgg
    20581 atatatggaa ctgttataat atggatatgg agaaatggac aaagtagaat ttaacacgaa
    20641 caagatttaa ttataggagt gtactcaatg tggcttttag ggagtatttt tatattcaca
    20701 tcactattaa ttctatacat aaaatatagg gttgttttta ctggcgaaaa atgcaaaggg
    20761 aaaataatcg acattgtaga acaaaatgca ggttatgtag taggtggtgt taatgtcaaa
    20821 aagcatgctt atatagtgaa gattaaaaac aaaaaatatc atactgcaca tggttgtatc
    20881 tttttgtcat tgggaaagag aaatattgga aaagaaattt ccgtatttaa gaatgaaaaa
    20941 tatggaaatg aggttttcaa atgctttgat tttcgtatag agattgttgc tttgttagta
    21001 tttttatttg gcgtttttat gatctactca gccttatgat aaagccaagc aggtttcagt
    21061 ttgaaaagaa gttatacgca aagaaaaatt tagaagttat ggaggaaacc atatggaaaa
    21121 tttaagtgca tatagatact gtatcgctat gaaaaaaggt cgaaaaatat taaatctgat
    21181 tgtgggctgc ttaatgattc ttataagtat cattttcata accacaactg tttttagctg
    21241 tatttttatg caggaatttg tttattacac atttttagca atattcctta taattatacc
    21301 cctacctctt tttatttttg gaattatagg tattgtctca gctacaaaac gagttgaagt
    21361 ttataaagga aaagtgattt atcatattgg ttttaaaaat aaggaatatc gtatgtctga
    21421 tattaaaaca tcaaaaacaa aaagtgaaac atatagaaca ggattagatt atggaaatat
    21481 tgtacccacc tacagttatg ataaattaac tgtattctat gataaaaaag ggaaaaagat
    21541 ttttaaattt ggattggcat acgataatgt agaacgactg aaagcagatg ttaataatac
    21601 tcaaaaaagc atagcaaaac agcataacaa gaactaaata aatttcagtt tgaaaatggg
    21661 aaatgaaaaa gtggcaattt caaatataaa tacaattatt agtaatgata ttcaaaaagt
    21721 ttggaacatt gttttagctg ttgataaata taactcatgg cgaagtgatt tgagcaaaac
    21781 agaaatagac tttacagaaa atgtgatacc taaaaagtgt tttatgaaac cttttgtaaa
    21841 aacctatttg aaaaaacaac aaaagcaatt tgttctggac ttaaagaaag cattggaata
    21901 ataaaattca agattggaga tttagaaatg gcttcaagta aagattattt acaatttgtt
    21961 ttagaacaat tatcagaatt acaagaaata acatatcgtg caatgatggg agaatttatt
    22021 atctattatc gtggaaaaat cgttggcggt atatatgatg ataggttgct ggtaaaacca
    22081 acaaagtccg caatttctta tatgccagca gttacttatg aaattccata cgaaaatgct
    22141 aaagaaatgt tattggtgga agaaattgat aataaagatt ttctgatggg gttatttaat
    22201 gtgatgtatg atgaactacc aacgccaaaa cctaaaaaga aaaaataaac agtttttagt
    22261 ttgacaattt catatccata cacacaaagc agttagtctt tatgattgac tgctttttaa
    22321 caaaagacac cgcttaggtg ttaagggtgt cttttagagc tattttattg tcatatcaag
    22381 gctcactcaa tcgtggtaaa ttcgtggtaa attgaatgat tttctatact tcaaattgct
    22441 tgaaagtata gtgtttatgt ggataatcga aaattatata taaaatttaa ttaaattatt
    22501 gtataatttt atgtaaaaac ttctatgtac caatgataac ttctatgagg aattaataat
    22561 tcttaaattt tttagaaaga ttttgacttg aaaatacttg taatataata tataaattaa
    22621 tatactgaat aaaatcaatc tggagggata attatgaagt gtacaaactt tactttcaaa
    22681 ggagaggaag gtttagatat atatacatat aaatgggaag atgaaaatat aaaaaaacca
    22741 aaggcagtta tccaaattgc acatggaatg gctgaaactg cacaaaggta tgagactttt
    22801 gccaaggtac ttactaaaaa tggttatata gtatatatca atgaccatag aggtcatggg
    22861 aaaactgcaa agataataga aaatgttgga catttagctg aaaaagaagg atttagatgt
    22921 cttgtagagg acatgtatac tttaacaaat attataaaga aagaaaatga agatctgcca
    22981 atttatctat ttggacacag catgggttca tttgcaagtc aaagatatat aatggattac
    23041 agtaataatt tatctggtct tatactatgt ggttcaaatg gaaagcaagg aatcattcta
    23101 aatcttgctc atctgataat caatcgtgag attaaaaagt atggaagacg ttctaaaagt
    23161 aataaaataa ataatttgat atttggcggc gaaataataa gaagaaatga aaagactaag
    23221 tttgactggt taagtagaga taaagaacaa gttgaaaaat atataaatga cccattttgt
    23281 ggagtagtgt gtagttgtgg ctttttttat gatttagttc aagggttaaa agaaattgag
    23341 gataaagaaa acttaaaaaa agtgccactt gatataccta tttacataat atctggagat
    23401 aaagacccca taggaaaaaa tggtaaagga gtcttaagac taagggatag atatataaaa
    23461 ttaggagtaa aagatgtaac ttgcaaactt tacaaagatg gaaggcatga attgttgaat
    23521 gaaataaata gagaagaagt ttttgaggat ataatttgtt ggttaaataa taaaatagaa
    23581 atattgtaat aaaaaaatat aatgatatat ttgctttaaa tttatttata tataatattt
    23641 gaaaagtgga ttatgtatat gcaaagtaga aaagagagcc cagaagtgat tttttgctat
    23701 aatgccattt attgaatagg tgggtgttat tataaataaa ttattaacac tcagtattat
    23761 tatcattgta tatggaattt attttattta aaattccttg aaagtttaaa agtttaaata
    23821 tagtaagttg taataaagag aaaatctaaa tatttaaatg ctatttaatg tgaatctatt
    23881 aattaggtta tacttaaact taattaatag attttatatt tcaagccaat gagatagggt
    23941 tttagattaa aatataacca atggttaaat tacagacatt ttgttaactt tccctcgatt
    24001 tactagtaaa tatttttttt atatacttaa attacaacag atgtactagg gaggtatata
    24061 tgcaaattaa aataggtaaa gtcatacagt gtcttagaaa agaacgaaat ttaactcaag
    24121 aacaattagc aaagtttata ggtgtgtcaa caccagcagt atctaagtgg gagagtggaa
    24181 attcttaccc agatatagaa ttattgcctt tattagcaga cttttttaat gtgtctattg
    24241 ataagctttt aaattacaag attgatttaa gtgaagaaga agtaatgaaa atttataaag
    24301 aattagaatc aggctttgct agaattgaaa ttgatttatc aacagaagaa ccaaaagaag
    24361 aatttagaca agatttagaa tctgtaaaaa agctttccaa tatgtatata gagaagtatc
    24421 ctaaaagcta tttattgaag ctaaggatat gttcgctgta tcagatgtat tcatataaat
    24481 ttggtaagag tgaacttaat gacagagtaa aagaaacaac gaatattctt gaagatatag
    24541 tgagaaatac agatgatatc caaataaaag aaacagctct tattatatta tcaaacgcat
    24601 attgtatgtt ggaggattat gaaaaggcag agttgtattt aaatatgata cataagtcaa
    24661 taggggatac aagtgttaat ttagctatga tatatttaaa gcaaaataga cttgaagaag
    24721 cagaaatatt gcttcaaaat aaattgttta gtaatgtatt taatataagc atggattgta
    24781 agggaataat taatgtatac aaaaatcaat acaaggaatt aaagaaaaaa ttggagaata
    24841 gaaattttaa taaaaatgca attgagagag aaatggagta tataaaaaat aagttgctgg
    24901 ggtatgcaaa tctttcttta gaaataaaaa aaatgctcag tgaagataaa ggtgcatttt
    24961 ttagtatgta tatggattat atggaattat ctctaatttt tttatttttt aacatgaaag
    25021 aagaagcaaa aaaagcttta tatagtctaa aagaaatatt agaaaaatat cctatacatg
    25081 aaagtttgga tgtaagtcaa atgagatttt ttgataaggt agagtctaaa aatttatata
    25141 cttttaatat atatacaaac ttgttaattg tacttaatga tgacagttat aatgagctta
    25201 gagaagaacc aatttttaag gatgtaattg aaaagatttt agatatggaa aaaatgttga
    25261 aaaataaaga ataagtaaaa atttaatata ggacttaaag attaatcaaa ttaaaagaaa
    25321 gtgtttcaaa ataaaaattt gaatcacctt ttttgtcggt cttaaacagt tatttagaaa
    25381 aatagaggtt tcaaaataga aatctgaatt atctgtatta ttacacaaaa atagaaacct
    25441 aaatttataa aaatagaata aagtttgtta tataaaatgt aattttgtct ataaaatctc
    25501 acctgttttc ttaactttaa gcgtgaaaaa gaggatgtat catgaatttt ttagttcatg
    25561 atgcatcctg ctttgtatga aatccaatat atctttatta tttaaacaat ggaaaagagt
    25621 cttatttata tttggagaca tctcttttat ttaattatga agttttatac agttcaataa
    25681 ataggaatta tatttagaaa ctcatgacat tatttcttag atagtgatta aatttatcat
    25741 attccatttt agataacttt tctgggtaag acattacaat caggttatgc ccattaaatt
    25801 ttttatggta tggtggatga atgtgttcat aattatttgt cttatatttt actctttcat
    25861 agaacgcctt gcgataaatt gaaatctcat caattggaag gtcaatttct aagataatag
    25921 tttttccttt cttatttaaa agctctaacg ctctttgccc atatctatta ttgcgcattt
    25981 ctggaaaaat gcagaaatgt tctacataga taaagtcatc tgtttcccaa cataaaatta
    26041 tgccgacaaa ctggttttta tcataaatta aattgaattg atattcttta tttttcaaaa
    26101 tttctgcttg caaagaagat tttctttgtt catgaaatgg gaaactaatt ttatataatt
    26161 ccatagcctt gtaatataat ttattttcac tggttcttaa ccattcaaat ttcactttac
    26221 tcctcctaat cacgaaaatt ccaatttatt tatgagttca ttttaccata gtcagtattt
    26281 gcatacaatg tgttttaagt tgagtgtcat ttctttcttt tatttatgct tatatctcat
    26341 agtctaagag ataattgctt aagacataac taaaaactat tatattaagc tttgataatc
    26401 taaaaacagt atatttatgg acttttctag gtctaaaagt aatcttaata attttagaag
    26461 ttacaaaaaa gttacataaa tttggaaagc tataatatac atatataata taaggttaaa
    26521 actgtaatga ataatattaa tttaaaattt gaacatggaa ggagattatt atggagaaaa
    26581 gagaaaagag gataataata tcatctttat taagtgtatc aattttaatg gggttggtaa
    26641 gtatatattc tatattaaat aaagaagaca taattttaac tgttaagggt caagagcaaa
    26701 aagtatcttc ctttaagaaa acagttgagg aacttttgga tgaacagggt gtaaagtata
    26761 attctgaaga taagattaat ccaagtttag atacagaact aaaagatgat atgaaaataa
    26821 aagttgttaa ggtaactaaa agtaaaaaag aagagattga aaaaattcca tttgatacaa
    26881 agcatgtaaa tgatagtaat ttgttaaaag gaaaatctaa agtttatcaa gaaggtcaag
    26941 aaggagaaaa aaaactagtc tataatttaa cttaccatga tggaaagtta gtcaaaaaag
    27001 tcttatcaaa agaagtaata tctaaggagc caactacaaa aattataaaa tatggaacta
    27061 aagaaaaagt actaatagca tcaagaggag caaatataag aggaggcaaa catatgaaag
    27121 tggttgccac tgcatatgca ggagatacaa taacatctac tggtacaact ccaagatggg
    27181 gtgttattgc agttgaccca cgtgtaatac catatggaac aaaagtatat atacctaaac
    27241 tgggtatgac ttttgtagca gaagattgtg gaggtgcaat taaaggtaat agaatagaca
    27301 tttttatgaa cagtgaagga aaagcttcaa attggggaag gaaaagtata gatatatatc
    27361 tacattaaat tagtgaatag aataacttta cttgaaggac aaaaaagtat aaaatatgaa
    27421 ttaactaaac tgttagatta ttcttaaaac ataaaaatat atctaagggg ggataagatg
    27481 aaaatagtct gcttaggaga cagtttaacg tatggatttg gagtatcacg aagtaattca
    27541 tggacaaaca ttgtaaataa agagactcga ttagaaatag taaataaggg tataaatggt
    27601 gatacaacaa gtggtatgtt agctaggttt aatgaagatg ttgtaaaaaa ttctcctgat
    27661 atagttttta taatgggtgg caccaatgat tttattgctg gtgcgggaaa tgaaattatt
    27721 aattctaata taatggctat ggtgcatcag tcatattcaa aaaatattat acctataata
    27781 ggtataccat taaaaccaga tattccaaat gttagggaag attggagttg ttttactgat
    27841 tttaatatag tatctcaaaa cttagaatca tatagttatt ggataaaaaa attttgtatg
    27901 acatttaata ctaatttcgt agatttttat tcagaatata ataaaaatat ggaactagaa
    27961 ggatataaaa aattatattt tgatgggtta catccaacca aagagggtca tagaataatg
    28021 gcagacattt ttattaattc aattaataag tatatagaag agttatagat tacattaaaa
    28081 tgcttgttta tgcgtcagtt gcaataaata catacagtag agaggggttt attatggatt
    28141 atactaaaac ttatgaagag tggataaagg gttcatattt tgatgaagat acaaagctag
    28201 agttggagaa tataaaaaat aatgaaaaag aaatagagga tagattctat aaggatttag
    28261 aatttgggac tgcgggtctt agaggaataa ttgaagcagg aacgaataga ataaataagt
    28321 acacagttag aagagctact tttggattgg caaactatat attagaaaac acaacaaaag
    28381 aagaaacaag tagaggagta gtaatagctc atgataatag acacaagtct agacaattct
    28441 gtatagaatc tgcaaatact ttggcagcat gtggtataaa agcatatata tttgatagtt
    28501 tgagaactac tccagaatta tcttttgctg ttagaagctt aaatgcaatc gctggtatag
    28561 tcataacagc aagccataat cctccagaat ataatggata taaggtatac tgggaagatg
    28621 gagcacaagt tatgccagag attgcaaatg caataacaga gaaagtaaat agtatacatg
    28681 attatagtac aataccaacc ttaacggaag ctaataaaaa tttggtagtt ttgttggacg
    28741 aatcacaaga tactaaattt atagaagcag taaaaagcca aattataaga aaagatttag
    28801 ttaaaaatgt aggtaaaagc tttaagatag tttatacacc tctttgtgga acagggaatg
    28861 ttccaataag aagagcattg aaagaagttg gttttgaaaa tataattgta gttccagaag
    28921 aagaaaatcc agacccaaat tttgcagggc ttgattatcc aaatccagaa gagaaaaaag
    28981 ctttaaatag aggtatatta ctcgcaaaag aaaaaggagc agaccttgta atagcaactg
    29041 acccagattg tgatagagta ggtgtagcag taaaaactac tacaggtgag tatgctttac
    29101 ttacaggaaa tcaaattggt ggtatgctga cacattatat aatagaagga ttaaaagaaa
    29161 ataataaatt aaaagaaaat cctacaataa taaaaaccat agttacatca gaatttggag
    29221 cagatatagc taaagcaaat aatgttgatg tattaaatgt tcttacaggt tttaaattta
    29281 ttggtgaaaa aataaaatta tttgaacaaa ataaaaatag aagttatgta tttggatatg
    29341 aagaaagtta tggttactta gttgggactc atgctagaga taaagatggt gtagtttctt
    29401 cattgttaat atctgaaatg gcagcatttt actattcaaa aggtatgagt ttatatgatg
    29461 gtttaataga actttataaa aagtatggat ttttcaaaga acagactata tctttgactt
    29521 taaaaggtat agaaggtgta gaaaagataa aagaaataat atcttatttt agagaaaatc
    29581 aaattgatta tataaatagt attaaagtag ttgataaaaa agattataaa aatggtatag
    29641 ataatcttcc taaatctgat gttttaaaat actttttgga agatgaatct tgggtagcta
    29701 taagaccatc tggaacagaa ccaaaactta aattttacat agctgtaaaa ggagctagtg
    29761 atattgaagc agataaaaag attcaaggtt tgaaaaagta tatagatgac atggtcgaaa
    29821 aattaaaata aaatattatt attttataag ataattttgt aataatattt atttagctga
    29881 aaattataat ttactttcat tgagtagaat atggaaatgt tagtagaatt gttattttca
    29941 gcttttattt gtgttatttt tacttaaata attatattat agaatgaatc tgagtataat
    30001 taatattgta taatgaaatt aatttgatag aaaaggggat atttatgttt ggtatagata
    30061 agaaattgat tgaatatata attgcaaaat ccaattacag tgaattaagt tcaaagtcag
    30121 cagaagtatc tttcttctta atgttgtcca tatttccttt tttaatattt acaataagtt
    30181 ctatagccta tataccgatt cttcatttaa ataagtatat agccttgttt agaaatatga
    30241 tgccagaagg tgcttttgct gtgttatctt caatcatagt ttctgcaata gacaatagaa
    30301 acctgaaatt tttagcagtc agttttgtac ttactatgtg gacattttca agagcagtaa
    30361 aagctcttat taaaggaatg aatagagcct ataaagttaa agaaactagg tcttttttta
    30421 aaattttatc tatatcattt ttatttacaa taatgctttt ggtccttatt tttttatcta
    30481 tgatattttt agtttacggg gaaaaaatag gttattttat ttttaatctt gtaggattgg
    30541 atgagatatt tataaaaata tgggatattc taagatacac tgtaggtata ataacaataa
    30601 tagtgatatt tacactttta tataaataca ctccaaataa aaagttaact attaaagaat
    30661 ctgcgccagg tgctattttt gctacttttg cttggttttt agtatcattt ttatattctt
    30721 attatacaaa ttactatgct aactatgaag taatctatgg aagtatagct gaaataattg
    30781 tacttatgac ctggatgtat tttagtagtt ggtctatcgt tattggctat gaggtaaatt
    30841 caagattgta ttttagaaag ataagacatg aaatgttaaa gtaaagtatt taaaataaaa
    30901 gagagtattt agtattataa atgtaattga attaataaag aaatattgac atttaagtta
    30961 aaaagtctag aatttttctg ggcttttttt atttttagta taacttgaca aattttattt
    31021 aatgggatag ttttaattta taatcatctt taaaaagatg actattgata agtaagagat
    31081 aaaattggta agtatcaaaa aatatactaa ataaaaatta tagtcctaat gagttaattt
    31141 ctgtattttc aaataatgca gtatttagtc atgtgttttt atatgtgcct gtatttctaa
    31201 ttaccaatat attagaataa gctactgtaa ttaggtttag aaaaaagcga cataaataat
    31261 tataaacaaa taataaatta cataaaatta aatttattca caagtatatc ttataaaata
    31321 tgttataatt aatagaaaat tgtcatataa ttaattaagt agtattatta taaataacat
    31381 tgaaaggtag tggttagaat atggataccc ataataaata tgtaaatttt ataaaaaata
    31441 tacctgtacc ttttttatat tgtagaattg taaagagaca agaagatata gaatatcgag
    31501 tagaatatat aagtaagggt atgggcaaag tattacaatt agaagaaggt atttgtgata
    31561 aaaatatatt agatgtattg cctgtattta agtctaaaaa atatttcaaa gagttgttct
    31621 caaatgaagt ggattgtata aaaaggtaca ttccgacact taaaaactgg ataaatataa
    31681 aaaaacagat aataggggat tcatacataa ttttgtattt tggtaaaatt gtatttgatt
    31741 atagacagat aatcgattcc tttgataaaa aggaaaaagt agcttatatt aaagacgaag
    31801 aaggcatata tatagattgt agtgaaaatt taataccaat attaaataac aacattaaaa
    31861 caacaaaaga tatctttggt aaaaatgata tagaagtatg gggagagaat acaggaaaat
    31921 tatttagaga tgattataga gaaggagtat ctagtaaaaa aagattttta caaaatcttt
    31981 ttgaatatga agaaacattt tttatggttg aaaaatattt tttgtatgat gaagacgaac
    32041 ttttaggtac tatagggata gtagacaata taatatatag tggttacagt aatagaaatt
    32101 ataactcaaa agatttaatg aagatgatag aacactcaat tccagagaat atgttttata
    32161 aagatgtgta tggaaattat attggattta attcaggttt tttgaattta gcttgtatga
    32221 ataaagaaga attattaggg aagaatagtt ataaaatatc agaagaagaa gctttaatag
    32281 ataagatatt tgaaagtgat aagggtgtag ttgaaaataa aaaagtagtt acatttgagt
    32341 taaatataag tatgaatgat gaaaacaagt gtattgagat tacaaaaagg ccgttttttg
    32401 atagctatgg aagtgttatt ggaataattg gaacagcaag ggatataagt agaagaaaaa
    32461 gattagaaga ggaaatggat aaaactagga tggaattttt tgcaaattta tcccatgaac
    32521 ttagaacgcc tataaattta atatcatctt cattacaagt gatagaaaaa aaagaagcag
    32581 atttaataga atcaaatgat actttaaaaa gaaatctagg tataataaaa caaaatggaa
    32641 atagaatatt gaggttagta aataatgtta tagactttac aaaaatgcaa tcaggatatt
    32701 tagattttaa accagaagaa tctgatataa ttgcatttat agaggagata tgtatgtctg
    32761 tagctgattt tgcaagccaa aataatatac aacttacatt tgatacagaa atagaagaat
    32821 tttcaatgtt atttgattca gaaaaattgg aaagaataat attaaattta ctttctaatg
    32881 gaattaagta caataagaaa gatggaaaaa taaatatatt tttatatgtg aaagataatg
    32941 tatttaatat gaaaatatct gatagtggaa taggaatacc aaaagaaaaa atagataaaa
    33001 tatttaatag gtttgaacag attgacaatg aactttctta cagagttaaa ggaagtggta
    33061 ttggactttc attagtgaaa tctttggttg agttgcatga gggaagtata tctttaaaaa
    33121 gtcaacttgg tattggaagt gaatttatag tttcattgcc tgttagaagt aaaaataata
    33181 ttgaaaaata taatcataaa agagaaatca gcaatgaact aagtaaaaaa ttagaaatag
    33241 agttttcgga tttataagtt taaatataaa aaataaaatt ttaaaaaagt attgacaatt
    33301 gatttagaag ggtttaaaat aaattacaac ataataaata aaaaggcgat gaataggaag
    33361 agtaaatcta attcgattac cagagagaag agtccattgg ctggaagact ttttaaatta
    33421 gagggattga aaactaccta ggagctactt tctgaagtca tctgcattag tagattttag
    33481 taagaatagt cgttagctgc gttaaagtgt aaagtgagtt ttcatgacat atgaaaacta
    33541 aattaggtgg aaccgcggga ataatactct cgtccttatg ttataaggat gagagttttt
    33601 tgttatttaa aaatataaac agtaatcata ataattatag aaaatataaa agcgatgaat
    33661 aggaagagta aatttaattc gactatcaga gaggaaagtt cacaggctga aagactttct
    33721 aagtttgaga aattgaaaac tacctaggag ctgtggtctg aagttacttt aaaaagtttt
    33781 agtaagacta accgttaact gcgttaaagt gtaaagtgga ttttatcaat aaatgataaa
    33841 atcaaattgg gtggaaccgc gagtatggac tcgtcccttt atatagggat gagtctattt
    33901 ttattgcaat aaaagattga aaataaaaaa aaatcggaaa attataaatt taggaggaaa
    33961 ataaaatgga gaataaagtg aaaattggag tactaggata tggagttgta ggaagtggac
    34021 ttatagatat aatagataat aataaagaaa aaagaaatat agaaatagtt ggaattttag
    34081 ttaataattt ggaaaaacat aaggataaaa aatattctaa tataataact aataatatag
    34141 atgatatatt taataaagat atagatatac ttgttgaagt catgggtggt ttagaaccat
    34201 cattatctta tataaaaaaa gcattaaaca ataaaattca tgttgttaca gcaaataaag
    34261 atttgttagc tgaatgtgga gatgagcttg caaaattagc aagtgaaaat aaagtaagta
    34321 ttaaatttga agcttcagtt gcaggaggta taccagtatt aaaaccaata atagaatcac
    34381 tagaaggaaa taatatagat agtataaatg caattttaaa tggaactact aattttatat
    34441 tatctaaaat gtatgatgag aatctatctt atgatatggc attaagacaa gcacaagaat
    34501 taggttttgc tgaagcaaat ccagagtcag atgtattagg gtatgatgct gctagaaaac
    34561 tatcaatatt atcaactcta gcttatgaca atagagtata ttggaaagat gtgtatttag
    34621 aaggaattac agatatagat gaaaaagata ttgaatatgc aaaaaaatta aattgtaaaa
    34681 taaaattgat tggtcaaagt aagtatgaaa atgataaagt aagtgctttt gttagacctg
    34741 ttttagtaga aaaagataat atccttgcta gaatagacaa tgagttcaat gctgtcatag
    34801 tgaatggaga ttcagtagga gaagtttctt ttgtaggtaa aggagctgga agtttagcaa
    34861 caggaagtgc ggtttattca gatgttatag atataataga taatagagtt tcaagtatag
    34921 attcttttac taaagataaa atacaagtta ataaaatagt tagagaaaag tgtggagcac
    34981 ttcttagatt taaaaaatgt aataaagatg aaattctaaa tatagttgag aattgtttag
    35041 taaaattcga tattttaaat gatgatgatg aacttgctat tatggtttat gctgattctg
    35101 aatatgaaat aaacaacagt ttatgtctaa taaaagataa aggatactgc gaaaaaatga
    35161 ataaaatgtt gaaaataagt taaaaaagaa aaaatataag tttatatgta acatattttg
    35221 acgattttaa tactatatag tatgagatga aacaaaacat ctcataaaaa aattaaaatt
    35281 aaagggagag atatgttata tggaaaataa aaaatgttat tcagaagatt ggtatgaaag
    35341 aggagaatct acagctaaat ggttccaaaa tgatagagaa gaatatgaaa gagaagcata
    35401 tgatgaagat agagaaagaa gaggttcaaa ctgtggatgt tcagattcag gagaaaatag
    35461 acctagaaac tgtgaaagat ttagaagaga agctgagata agagaaagag aagcaagaga
    35521 agcattttgt gaatcttcag agaaaaagaa agaggcatta gcatatgaat gtgaagctag
    35581 aaaattatgg gaagaagcag aaaaatactg ggatgaatat tcaaaataca actataaagg
    35641 aatcgaatat ttagcagaag ctgctagatt atttgatgaa ggtatggaat gtgaagctag
    35701 aagaaatgga aataatggag gaaacaataa taattgttgc cataaatgcc ataaatgtaa
    35761 ttgtaactgc tgtagaaaat aaaaaaatta attgacaaat caatagttaa aatatatcat
    35821 attatgtata ataaaaagaa aattcagaaa aaaataatga ttagaagaaa tataagtata
    35881 tttattagac aaatagtgct cagttagtga ggtgagtaca atatgattaa actcccatcc
    35941 tctagctttt gatagagggt gggagttttt atttattgat atatcttaaa tgaggataat
    36001 attgtaaaat aaatgagtat gagattgtaa aattaggagg taaaaaatga aaagtattaa
    36061 aacatcaagt atgaaagaaa aggtagatga aaagatatta agagagcaag taagttctat
    36121 aatagaagat ataagaaata ataaggatgt tgcacttaaa aaatataatg agaagtttga
    36181 tagaaataca agagatgaat ttagaattac taaggaagaa ataaaggaag cttataagca
    36241 tgtagatgac gaatttataa ataacttaaa gattgctgcc aaaaatataa gagaatttgc
    36301 taaagctcaa aaactaagtt ttgaaaaccc ttttgaaaaa gaaatttatc caggtgtaat
    36361 cttaggtcaa actaatattc caatagagtc atgtcttgca tatgttccag gaggtcagta
    36421 tccattgttt tcaacagctc ttatgcttat aatacctgca aaagtagcag gagtaaaaag
    36481 aatagtggca tgttcaccaa ctatgaaaaa tactgaaaag ataaatccta agacattggt
    36541 agctatggat atagcaggtg ctgatgaaat atatgcaact ggaggagttc aagctatagc
    36601 agcatttaca tatggaacag aaaagattaa tccagttgac ataattgtag gaccaggaaa
    36661 taagtttgta actgaagcta aaagacaatg ttatggacaa gtagggattg attttgtcgc
    36721 tgggccaagt gaagttctta taatagcgga tgaaacttca aatccagttt atattgcagc
    36781 tgatttatta gcacaatgtg agcatgattt aaatgcaaga ggaatattat tgacaaatag
    36841 cttggaagta gcacaaaaag ttgaaaaaaa tatagaaagt atgctaaaag atttgccaac
    36901 aaaggacata gcatatagtt catgggaaaa taatggagag ataatattgg ttgatgatat
    36961 ggaagaagcc attaaaataa gtaattttta tgcaccagaa catttagaag ttgcagtaaa
    37021 tgagtataat gatatttgtg atagattaac taactatggt tctttattta ttggaaatct
    37081 ttctgctgag gtgtttggtg actatgtttc aggtaccaat catacattac caacacttaa
    37141 agcatcaaga tatactggtg gtgtttgggt tggaactttt atcaaaactt gtacaaagca
    37201 gatatttaat gaaaaagcta tacaatcatt agcacctgta gctgaaaagc tggcaaaaga
    37261 agagggatta tatgcacatg caaaggctgc tgaggttagg tttaaaaagt agtaaaaaat
    37321 tttattttgg cagtcgagac ttagtattag actgagataa ggaaaacgct gagaacctga
    37381 ataaatacta tattttgtgg gtctcggcgc ttcttttata tctgtatata atagaataat
    37441 actatctgtg tgtttaaata ctaacttaat atttcttttc taaataatgt ttatgaaata
    37501 gttaatattt ttagttaata cttgaaaaaa acttttgcta actgtgcaaa ttcatctgca
    37561 tttgtcaata tagcagggtg tcctccctga ctaaaaatgt aaatacttgc ttttgaaata
    37621 aaagttgcca tttgcttgta ctcttcttca agattatgac gacacatttc gtcttcctta
    37681 cttcctgtaa ataaaattgg catttctaat ttacacaatt ctttatgaaa caaagggcgt
    37741 ttctcgtttg cacattgcaa tagagctttt gtatcaagat taacaacatt ctcccaatct
    37801 tttccatgac accattcata gaattttcgt gcttgaatat cttgctttga tttttccctt
    37861 ccagtgatta gattatctat gaagttatca ttaagagtac gtccatcaaa gctatctgct
    37921 ataattgctt caactaaatc gggacgttct aatccagtat taacagctgc ccatgctcct
    37981 ccacttgttc caattaagcc aactttacca caattcaaat gttcaatcag tgctattgtc
    38041 tgtaaggctt catcatgcca tatgtcagga gaaaattgag aaactctatc cgactgtcca
    38101 ttacctaaaa aatcaattaa gatacatcta aaattttctg catataatgg cacaagtgct
    38161 ttaaacatat tagaagaacc agtattacca tgcaggaaaa ttatcggttt accttgtcca
    38221 tattctttat aaaaacaaga attaccttga tactgaaaat atgacatata ttttcctcct
    38281 ttttatttgt taagttaatt ataacaatat aggtatgaat gaaaaacctc atgttctttc
    38341 ttagaataaa aatgtgccac gcataaaacg tgacacattt ctaattataa attttgctgt
    38401 ttaagtattc tttgtatgct tttctctgtc aaaaagtatt tctctgataa ctgcttgata
    38461 ctcattccat tttggaaatt tatacagatt tgagaattac gagaagctaa gacttgtttg
    38521 gtgtttgtgt tttcacccca atgctttttg tgctcttgct ttttgggaat ataaatcact
    38581 ttaccatcta tatattcttg cacttgctca atcagttctt taggcagtaa gtcaatcgaa
    38641 ttttgatagc tcattttgca cctcctaaat aattattctt taggattagc aaaggctact
    38701 gccactcaca attaaaaata aaatttttta ttatgtacaa tagcctttgc tatgcacaag
    38761 ttccaattcc cataaactaa atactccttt ctggtttgaa aaattcatct gaacattgat
    38821 ttcgctttta agatagagtt caatgacaaa tttacatttt tattatatat attcagatag
    38881 ataattgcaa ctgtctttgt atgaggatat tttattatag tcaatactat aatatgtatt
    38941 tatatcatca aactaatatg aacagttgaa aggaatatga acaataaaac ttagtcagga
    39001 agaataatta tgaagcagac aatagagaaa tttgatttta aagttttatt gaaaatttat
    39061 tgacaaattt aacttgtaaa tattatacta aacttaataa ataaagttta taaagtaagg
    39121 tgttgtctat gaaaaatata gttggaaaac cgcaaacgat aaaaaaagta aatgaagatt
    39181 taataaaaaa cattataaaa aatgaaggtc ctataacaaa accagaaatt tcaagcatta
    39241 ctgaattgag tttagctaca gttaataaga ttgtagagca attagctttg aaaaatgaag
    39301 ttaaagtaag tggactaagt gaatctactg gaggaagaag agctcaatta tttgaaataa
    39361 atgcaaactt agaacacata atagctttat attattatag aaattgttgt ataggggtag
    39421 ttgccaattt attaggtgaa ataatttatc aagaagaatt taatataaga atggatacgt
    39481 atgaaaacgt taaccaagat actttttttg ttatagatac tctaataaaa aaggaaaaag
    39541 gaaacaatat aagggctatt ggaattggtg tcccaggagt tgtaaaaaaa ggtgtagtta
    39601 aaaatatacc aactataaaa agttgggaag gtataaattt agaaaattta ataaagagta
    39661 aatacaatac taaagtgttt atagaaaatg atacaaatat tactactatt gggatttatc
    39721 aaaaacagta taaagacaaa tataaaaata tggctcttat gtatttagaa gatggtattg
    39781 gttcaggtat agttataaat ggtgaattgt atttaggttc tacaaatttt gctggagaat
    39841 taagttatct aaatatagaa tttggtaagt ataactctaa caacttaaat cttgaagatt
    39901 atattatgag tttaagaaaa agatatttag aaagtaaaga taataaattt aagaaagaaa
    39961 ttttatctat aatatcaaac tttataagga ctcttgtatg tgtcctaaat ccacaagcta
    40021 tgattataca gtgtagtata ttaaccaaga gtgacatgga gtttatagaa aaagatgtaa
    40081 gcaataatgt tggagaagaa aattttccta aattaataaa agtagactca ttgagagaag
    40141 gaagtataaa tggagtaatt agtatgtgtt taaaagaaac tgactatcaa tattccttat
    40201 ctaataaaaa aggaggatat taatgtgaaa tatttggttt caatagatgg agggggaaca
    40261 aaaactaaat tttgtgtaag tgacttagat ggaaacatac ttaaagaaca taccactggt
    40321 tcaactaatt ataagtcagt tggaattaaa aaaacatatg aaaatattaa taatggattt
    40381 aaaaaaatat taaaagattt atatatcgat tatgacgata ttgagtacac tgtatttggt
    40441 atatctggtt gtgattctcc taatgattat aagattataa tggatgaaat attaaaaatt
    40501 gggattaaca aagaaaaaat atatctggca aatgatgcag ttttagcttt ttatgcacaa
    40561 gctgattccc ctggcttagt aattgtggct gggacaggtt caattatact gggaattaaa
    40621 gaagatggag aaatatatag agttggtgga tgggggtata attttagtga tttgggttct
    40681 ggatatgata tagggagaaa attattaaag aaagtattgc tttattgtga tgaatgtcat
    40741 gagtatagtg atttatttag ttgtgtcttg gacttctttg gagcaaatag ttttgaacaa
    40801 cttgcatata tgattactga tataaatgat aatgttgaaa tagcaaactt agcttcatta
    40861 gtgattgatt gtgccgaaca aggtgataaa ttggctattg aaatattaag agaatcatca
    40921 actgaactat ctaaattagc tcaagtaata ttgagaaaaa tatctaatcc aatgaaaatg
    40981 gataaaagcg aaataaatat agttttgtct ggtggtacat taaataaaac tgtatatgct
    41041 caaatgttaa tgaataattt aaaaacagaa aatacagata aaaatttaaa atttatatct
    41101 caagaaaatc agccagtata tggggggata agacttgcta tggcattagc taataggagg
    41161 gtcaagcatg gatagaaaaa aggtaatagt acaaattttt actggaggtt ttaaggctaa
    41221 agaaataaag tttaatgata taaaatgtaa actactagaa ttattggact gtattgatat
    41281 agaaaaggtt atcatgggat ggagtgtaga tgaagaatta tatgtagaaa ctaaaaaact
    41341 attaaataaa tataatgttg aactatatct ttggttgcca tgtttttctg aaataggatt
    41401 acttgaaaaa agtaatttac taattgatta tatggggaag gaagtcaagg gctatgcttt
    41461 acaagaggat gaaaattttg agttttattg cccaaataat aaggaaaata taaaaaatat
    41521 aaagaaaata tatagtactt attttagtga tattaaattt gatggaattt ttttagataa
    41581 aataaggtat ggttcttttt cgaataaact aaatggtgtt tttaattgtt tttgtaaaga
    41641 ttgtttaaat atatataaaa aaaataatat tgataaagag tcgttaatga gagaaatgaa
    41701 taatgtgtct aagggagtta tagataatga agatactcca tttggtataa cagaatacat
    41761 taatggaaaa tacaaattta aaaataaaat atgggaagat ttttttgaaa caaaaaatca
    41821 aaatatatac aaggcattat tagagataag tagttatttt aaaagtaagg gattgaaaat
    41881 aggtatagat gctttttctc cttttatttc ttactttaca ggtcaagatt tagaaaaatt
    41941 acaagaagta gcagatttta taaaaccaat gatgtataga actacaaaag ctccagctgg
    42001 tttaccattt gaatttgaaa ggtttattga tgaatccata cataagaata aagagattgg
    42061 aaaaagaaat ttcttagata ttttaggaat taaggagtat gaaggagatg tatatcctat
    42121 agaatttgta ctagaggaaa tcgattttat gacaagaaat cttaataaag atatatatgt
    42181 aggagttgaa ataaataaaa aggaaattat atctcctgtt acacctaagt acataagtga
    42241 aaatatttca aatataaata agacaacagt aaaaggatat gttttatctt gggatttgtt
    42301 gtcagcacca aaagaaaata ttgatgaaat tataaaatgg tttcggaatt agtgaggtga
    42361 taaagtgagt aagatattgg aaatacaaca aatatataaa agttttggaa aggtagatgt
    42421 tttaaaaggg ataaattttg agttagaaaa gggagaagta agagctcttt tgggagctaa
    42481 tggagcagga aaatctacac ttattaaaat tttaggagga gttcattctc aaactaaagg
    42541 taaagtaatt ttgactggta atgaaataat gtttaaaaat ccacatcatt ctaaagaaaa
    42601 tggtattagt ataatttatc aagaattaag cttgatacca acgcttacag tacttgaaaa
    42661 tatttttctt ggtagagaaa ttttaaaagg aagtgtgttt ttaaacaaga aagacatgct
    42721 tgaggaatat atgaaaattt gtgaggattt tgattttaat atagacccac atatagtagt
    42781 ttctaattta agtgtagcaa accaacaaat ggttgagata atgaaagctg tttcatgtaa
    42841 ttctgaaatt atcataatgg atgaacctac aacatcactt actaataatg aaaaagatgg
    42901 gctatttaaa ataataagta gactaaagtc taaaggtaaa acaatagtct atatttctca
    42961 catattagag gaagttttta aagtatgtga tagtgcaagt ataatgaaaa atggaattat
    43021 gattggaact tatgatgtag aggatttaac taaattaaag ataactcaac ttatgacagg
    43081 aaatgataat cacaaactta ttgagaagaa ggattataca tttgcaaaat atgaagagcc
    43141 accagtacta gaagtaaaga atataagctg gtctaacaaa ataaaaaatg tttcatttaa
    43201 agtttataga ggcgaagttg taggtcttgc aggtcttgta ggttcaagaa gaactgaaat
    43261 tataaatttg atatttggta tagataataa agatagtgga gatattttta tcaatggtaa
    43321 aaaagtagac ataacttctc ctaaggttgc tataaaaaac aaaataggat tgattcctga
    43381 agatagaaaa aatctaggat taattttaga acaagctata tacacaaact catcatcagt
    43441 acaaattgat aaattcaaga aatttttgtt tatagataga aataaagaaa ttgagttttc
    43501 taaaaaaggt gttaaggaat taggaataaa agttagtgat gtaaagcaag aagtaaaaga
    43561 gcttagtggt ggaaatcaac aaaaagtagt agtttctaag tggttagaga aagatttaga
    43621 tttaataata tatgatgagc cgacaaaggg aatagatatt gctgcaaaag aagatatttt
    43681 caatacaatc aaagaatttt caagtaaagg aataggagta atatttatat cttctgattt
    43741 agaagaagta ataagagtaa gtgatagaat tttagtaact agagaaggtt ctattgtaga
    43801 tgatttaaaa aatgagaata tacaggttca agatataatg aacagtatat ttaatgtata
    43861 aaaaatgaaa atggaggact gagatgaaga aagcttttga gaagttaaat ttaagagatt
    43921 atggagtatt attaggtttt ttagctttat gtatagctat aagtattgca actccatcat
    43981 ttttaggtaa acaaaatata cttaatcttt tacgacaatc ttctataatt ggaataattt
    44041 cagcaggtat gacttttgtt ataatatctg gaaactttga tatatcagtt ggagcagtag
    44101 cagctcttgc aggtgctata acaatgaaat ttgcgactgg tggaactaat ttgtttgcat
    44161 ccatgttctt aggtgtagcg atttgtgcag taataggatt aatcaatggt atagtagttg
    44221 caaagataaa tgtaccatca ttaatagcca ctatggctat ggtcactatt gtaagaggat
    44281 tgctgttgat gcttacagga ggatatccaa ttactgaaaa tataccaata cttgattaca
    44341 ttggaaatgg atatttgttt aatataccaa taccagtagt aattttcttt atagtggtgt
    44401 tagcttcgtt tattgtactt aataaaacta agtttggtag atatgtttat tctgtaggag
    44461 ggaatcaaga agcaagtaaa cttaatggta taaatgtaga ttctcacaaa gtgaaagtgt
    44521 ttattattaa tgctgtactt gcaggaatag ctggaatcgt actaacagga agacttggga
    44581 ctgcaactgc gattgcaggt gaaggatatg atatggatgc aattgcatct gtagtaatag
    44641 gaggtacatc agtggcagga ggttctggtt ctgtacttaa aactgttata ggagtattac
    44701 ttatgagtgt tataaacaac agttttaatc ttcttggaat agatgtatat ttccagtaca
    44761 tatttaaagg attaataatt ttagcagcag ttggatttga ttcttatagc aagaaaaaac
    44821 ttgcttcaag ataaaaaata agggggattt ttttatgaaa aaattaatga aacatttagc
    44881 attgttgcta tcacttgtta tgatatttgg tttagttggt tgttcaaatg gtggtgacaa
    44941 agaaaaaaat ggagaaaaga aaatagcagt attactaccg ggttcaacag gttactttgt
    45001 agcaactaaa caaggtatag atgcaaaatc taaagaatta ggtgtaagcg tggaatatgc
    45061 agatgctcaa tgggatgcta gtaaacaatt atcacaagct gaagatttta tggctaaagg
    45121 ggtagacatg attgcattat gtggagttga ttctgctgta agtgagagaa tagttaaagc
    45181 tgctaatgat tcagacgttc ctatagtagc atttacaaat tctataggaa gtaacccaac
    45241 tggagaattt aaaggtttag ttacatatat aggacaaaat gaggaagaaa caggagcatt
    45301 aactggaaaa attgctaaaa acttattagg agaaactggt gggaaagctg tattaataga
    45361 aggagtacca ggaactactc cacaagtatt aagaaaaaaa ggtcttgaaa aagaattaaa
    45421 agatagtaat atagaaatag tttataatca aacttcaaat tgggagaaag agcaagcttt
    45481 aaaggtaaca gaagatttaa ttcaaaagaa aactgatttt aatgttataa tatgtcaaga
    45541 tgataattct gctacaggtg caggtcaagc tttaaaagat gctggtctta aggataaagt
    45601 taaagtcata ggtttgggtg gaagtaaaga tggattaaaa gctataactg atgggttaat
    45661 agatggtaca acttatatgt ctgctgtaga agaaggtgga ttagtcatag aaaaggcatc
    45721 taaattcctt aaaggtgaaa aaatagaacc tgttacacaa attaaacaag ttgaagttaa
    45781 caaagataat atttcagagt tcaagggtga atggtaaatt gtcatagata ataaataaga
    45841 tttttagagt tactttagaa actatataaa gtaactcttt ttttaattta atttagtgat
    45901 aaattattga atagtatttc taaacaaata aaaaattaat ataaacaaag acttaattat
    45961 actaaattat aagtaaaact aatataaact tatggaaaaa aggaaaacgt ctaaagtatt
    46021 ggaattacta tagtgtaggt gtggtattaa aaaaacataa aaaaacataa aaaaattgtt
    46081 gaaaaaaata tagaaatttt gtataattaa agatttgaaa agtgcggtat acaaagccaa
    46141 ttcttttgta tataatatat ataaattcag aaaaaggaag ggatatgtat ggccaggcgg
    46201 ttatttttag aaaggattgg acttatattt ttaggttcag caatattagc atttggagtt
    46261 tataattttt attatttaaa caacataaca gaaggtggag tgttaggtat tttactactg
    46321 ttaaaaaatt tattcaatat acaaccagca atagcaaatg ttgtaataga tagtttacta
    46381 cttttagtag gatataaatt tttcggtaaa aaattcctta tatattcaat agtagcttct
    46441 ataacttttt cagtgttata tgacttattt gaagctatag gacctctagt accacaatca
    46501 caaaatatgc ttttatcaac tattttggca ggtgtaactg ttggaactgg tgtaggtata
    46561 gtagtaaaag caggttgtgc atcaggagga gacgatgctt tagcattagt aatttctaag
    46621 actacatctt tgaacatagg gcaagtttat ttagcaacag atgttattgt attgttgtta
    46681 tcattatttt atctatcagc gtttgatatc ttttattctt tgattgctgt tacaattagt
    46741 ggcaaggtaa ttgattttat ttattatcat ggtaaaagtt tggatatgga tataagtaat
    46801 gatatagttc cagaatgtta atataaatta aataacttta gattttatta ggggtggcag
    46861 atttgccacc ttttttttgt ctaaatcttt atagaaagta taatcccatc taggtttttg
    46921 caaatctcaa atatagaatt atgttggaat gactgggaat acgattgcta gatgtgcatt
    46981 ttaaaaaccc aattttatat ttatgaaata ctaatcatta atggatgttt cttaatccta
    47041 tctttatacc taaaatgata agataaatga agtagcaata caaagctaaa atttgtaaaa
    47101 gagattaaat taaatggagg agctaaaatg ttggatatag ttatgatagc attgttattc
    47161 ataggatttg tttccatgaa gttacttgct gattggtgtg ggaaacaaac tgaaaaaaaa
    47221 taatgtaatg tatggaggga ttacctatgt ggtttctggc agttgtaatt ataatgttaa
    47281 taatatattt ggtatatgcg cttattaatc ctgaaaaatt ttaaacagta taaggctaat
    47341 aagtaagttg aattgggggg aacaattttt atggtgcaga tagtaatagt gttagcgatt
    47401 tttatgattt tagtaatacc tatgggcaag tatttatatc atatagctac taatcaaaaa
    47461 acatttggag atagactatt tgataaagtg gacaatttta tatataaggt atgtagtata
    47521 gataagaaaa aagaaatgaa ctggaaacag tatgcattag ctttattatt tacaaatgca
    47581 gttatggtat ttataggata tatcatactt aggactcaaa gtatgcatat ttttaatcca
    47641 agtggaatta aaagtatgga acaaggacta tcatttaata caataataag ttttatgaca
    47701 aatacaaatc ttcaacatta ttcaggtgaa tcaggacttt catactttag tcagatgaca
    47761 gtgataatat atatgatgtt tacatcagct gcaacaggat atgcggctgc tatggcattt
    47821 gtaagaggtc tagtcggtaa aaagaaaaca ttgggaaatt tttatgtaga tttaattagg
    47881 ataacaacaa gagtactttt accaggagct ttaattattg ggcttatatt agttacacaa
    47941 ggagtaccac aaacttttgc tgggacagaa acagtgacta ctatagaagg aaagcttcaa
    48001 gatatagcta gaggtcctgt ggcagctctt gaatcaataa aacatttagg aacaaatggt
    48061 ggtggattct ttggttcaaa ttcatcacac ccatttgaaa atccaacaat aatatcaaat
    48121 atagtagaaa tattatctat gatgatatta ccaggagctt gtgttgttgc attcggtcac
    48181 atgataaaga ataaaaaaca aggttgggtt gtgtttggcg caatgtcaat catattttta
    48241 ataggtctag tagtgtgctt taaagcagaa agtgcaggaa atcctatttt atcacaatta
    48301 gggcttaatc aaagtatggg aagtatggaa ggtaaggaag ttagatttgg tatagcacaa
    48361 tcatcattat tcacaacagt gactacttcc tttacgacag gtacagttaa taatatgcat
    48421 gatacactga ctcctttagg aggattagta ccacttttaa atatgatgct aaatgtagta
    48481 tttggtggta aaggcgtagg tctgatgaat atgttgatgt acgctataat agcagtattc
    48541 ttatgtggat taatggtagg aagaacacca gagtttttaa ctaagaaaat cgaaggaaaa
    48601 gaaatgaagc ttattgcttt acttattata ttacatccac ttttaatact aatgttctct
    48661 ggtctttcag tagcaatacc agcaggactt gaaggaattt caaatcctgg attccatgga
    48721 ttatcacagg tattgtatga gtttgcatct tcagcagcca ataatggttc aggatttgaa
    48781 ggtctaggag ataacactat gttttggaat ataacaacag gtatagttat gttctttgga
    48841 agatatgtgt ctattatagt actactagca atatcaagtt tgttagcatc taaaaaagct
    48901 gtaaatgaaa gtataggaac acttagaacg gataatttta catttacaat agttttagta
    48961 cttgttgttt taattgttgg tgctttaaca tttttcccag ccttagcgct tggacctatt
    49021 tcggagcatc tagtgttgtg gcactaaaaa attgggaggg agtaaagttt tatggaaact
    49081 aaaaaaacaa agtttattac aaaagatatt ttcaaaactt ccattataga agcttttaaa
    49141 aaattaaatc ctaaatatat gatgaaaaat ccagttatgt ttgttgtaga aattggattt
    49201 atagtaacat tgatacttac aatagtacct agtttgtttg gtgatgaagg caataactta
    49261 agagcttata atgggattgt aacaataatc ttatttataa cagtcctttt tgcaaatttt
    49321 gctgaagctg tagctgaagg aagaggtaaa gctcaagcag atacacttaa gaaaactaga
    49381 aaagatacag tagcaagggt tatagatacg ttaggaaatg aaaaaatgat aagtgcaagt
    49441 gagctaaaac ttggtgatat tgttttagta aatgctggag aagttatccc aaatgatgga
    49501 gaagttatag agggtatagc ttctgtggat gagtcagcaa taactggaga atctgcacct
    49561 gtcatgagag aatcaggtgg agatttcgca tctgttacag gtggtactac agttgtaagt
    49621 gactggttaa agataagaat aacaacaaaa ccaggagaat cgttcttaga taaaatgata
    49681 gctcttgtag aaggtgcttc aagacaaaaa acgccaaatg agattgcttt aaatactttg
    49741 ttagtagggt taacacttat atttatggtt gttttaatat ctctttatcc aatggcaaac
    49801 tatgcaggtg taaagattcc aatttctact atgatagctc ttttggtatg tttaatacca
    49861 actactatag gtggattgtt gtcagctatt ggtattgcag gtatggatag agtaactaga
    49921 tttaatgtaa ttgcaatgtc aggaaaagca gtagaagctt gtggagacgt tgatactatg
    49981 attttggata agacaggtac aattacttat gggaatagac ttgcatcaga atttatagca
    50041 gttggaaatg cagattcaaa agatttaata aattattctg ttatgtgttc attaaaagat
    50101 gatacaccag aaggaaaatc tatagttgat ttaggtatga aattaggttc aacaggtaag
    50161 acaaaagagg cagaggaagc tgagtttgta gaattttctg cacaaactag aatgagtggt
    50221 attaacttag ctgatggtag agctataaga aaaggtgctt atgatagcat aataaaaaga
    50281 gtaaaagaat ctggtggtac agtgccagaa gatttagaag aaaatgtaaa tcgagtagct
    50341 aaactaggag ggacaccttt agtagtgtgt gtagataatg agatatatgg aattatctac
    50401 ttaaaagata cagtaaaatc agggcttgta gaaagatttg ctagacttcg agagatagga
    50461 ataaagacaa taatgtgtac aggggataat cccttgacag cagctacaat tgcaagagaa
    50521 gctggagtag atggatttat tgcagaatgt aaaccagaag ataaaataga tgcaataaaa
    50581 aaagaacaat tagagggtaa aatagttgca atgacaggtg atggaacaaa tgatgctcct
    50641 gcacttgctc aggcagatgt aggtcttgca atgaatagtg gtacaacatc tgcaaaagaa
    50701 gcagcaaata tggtagattt agattcagac ccaactaaga tattggaagt tgttgaaata
    50761 ggaaaacagc ttttaataac tcgtggggct ttgacaacat ttagtatagc aaatgatgtt
    50821 gcaaaatatt ttgcgattat accagctata tttactcttg caatacctca aatggagata
    50881 ttaaatgtaa tgaaactttc tacatcattt agtgcgatat tatcagcttt aatatttaat
    50941 gctataatta tcccatgttt aatacctctt gcaatgaagg gagtaaaata tagacctatg
    51001 aaatcacaag ctatgttaat gagaaatatg cttatatttg gtcttggtgg agttatagta
    51061 ccatttttag gaataaaatt aattgattta ttgattacac ctttagtaat ggttcttaat
    51121 ttaggttaat aaatggagga tataaaaatg aaaacattaa agccagcatt acttgtaagt
    51181 attgtattgt tagttgtttg tggacttgta tatccacttg ttttgacagg tgtaagccaa
    51241 gttgcattta aagataaagc caatggaagt atgatagaag taaatggtgt aaaagtaggt
    51301 tcagaactta ttggtcaaag ctttacagat gtgagattct ttaagggaag agtatcatca
    51361 gtaaactata atacttatac aaaagaagat ttagtaccag ataaagatgg aaacacatct
    51421 tatggaggtg tatcatcagg gtcttttaat tatggagcta caaatccaga acttcatgat
    51481 agagtacaaa aagatataga acagttttta aaggataatc caactgtcaa aagagaggat
    51541 ataccaacag atttacttac agcatcaggt tcaggacttg accctaatat aagtccagcc
    51601 tctgcaaaaa ttcagatacc agctatagca aaagcgtctg gaatatcaga aagtaaatta
    51661 caaaaaattg tagatgataa tacttccaaa aaactttttg gagttttagg tgaagataga
    51721 gttaatgtat taaaggttaa tgtagaggtc gcaaaaatat taggtcttat atagtatttt
    51781 gtggaatttt agcaacaaaa tattacgcaa gatttaattt aaaggttaaa ttttaaagag
    51841 tgaaaatcga taatgatttt cactttttta tttgaatatt actaatattt ggaataaagt
    51901 gattgtaagt ataaaatcca aaaaaaggtt gcattatcaa aatgataata ctataatata
    51961 tttatcgtta tcaatttgat aatagatttg gacatatagg aggaaatagt atgttatata
    52021 ataacgcatt agagttgata ggaaacacac ctgtagtaag gctgaataat ttaggctgta
    52081 ctaatgggtg ttctaacata tatgtaaaat tagaaaaagt aaatccagca ggaagtataa
    52141 aagatagagc tgtttatgaa atgttagagg gcttagagca aagaggagaa ttaaaaaagg
    52201 gagatgtact agttgaagca actagtggaa atactggtat tgcattatct atgataggaa
    52261 aattaaaagg atatgaagta gtaatcgtaa tgcccgaaac aatgagcgtt gagagaagag
    52321 atttaatgaa ggcttatgga gcaaatttgg tgcttacaga tggtaaagct ggaatggcag
    52381 gttccataga aaaagcaaat gaacttttaa aagaaaatcc aaactataaa agcctaaaac
    52441 aatttgaaaa taaagataat ccaaatgcac attataaaac aacagcagtt gaaattatga
    52501 atgatgtcaa agatttagat atattcgtat gtggagttgg aacaggtggt actttaatag
    52561 gaactgcaag atatttaaaa gaacaaaatc caaatataag agtaattgca cttgaaccaa
    52621 aaaaatctcc agctatatca gaaaacaaga ctggacctca taaaatacaa ggaataggtg
    52681 ctaactttgt tcctgaaaat tatgattcta gtgtagttga tgaagtaata ttagtagatg
    52741 atgaagatgc atttgataca gttaaattac ttgcagcaaa agagggaatt ttagtaggga
    52801 tatcttctgg agcaaatata tttggtgcta tagagatggc aaaaaagtat ccagataaaa
    52861 agatagttac agtagctcca gatggagttg ataagtatat gtctatggga atattttaat
    52921 aattttattt gagggagtga atactttgtt taagaaaata aataaagata ttgaatatat
    52981 aatgaagaat gatccagcag ctaggtctaa gatagaagtt tttttacttt atccatcagt
    53041 tcatgcaatg ataatgcata ggatggctca tgctctttat aagaagaaga agctttttac
    53101 agcaagatta atatcccaga tatccagatt tatgactggc atagaaatac atcctggtgc
    53161 taaaatgggg gaaggtatat tgatagacca tggaatgggt gttgtaattg gagagacagc
    53221 ggaagtaggg aatagggtga caatatatca aggagctact ttaggagcta caggaaaaga
    53281 tactggaaag agacatccaa ctgttggtga tgatgtatta attggtgctg gaacaaaaat
    53341 actaggacct ttaaatatag gttcaaattc aaaaattggt gcaaattctg ttgtcgttaa
    53401 ggatgtacct aatggtgcaa cagttgttgg tataccagca aaaatagtaa aaataagaaa
    53461 cctagaacct gtaaaaaaga ataaaaaaga agtgtcctat gagtatgatg aattagataa
    53521 tgtatattat atataggatt tatataacta taaaataaac tttataaaaa ttattttaaa
    53581 aggtattttt ttcaaatttg aggacataat aaaaaagaac tgaatgttac agttttggtt
    53641 catcaatctt tgataaacaa gattttaaat ttgtagcgtc taggaggatt ttattatgaa
    53701 agcaaatgtt aatcaagata cttgtatagg ttgtggatta tgtccatcaa tatgtccaga
    53761 agtatttgat atgaaggatg atgggaaatc acatgttata gttgatgaag taccaagtga
    53821 tgctgaagaa tcagcagcag aagctagaga aagctgtcca gttgatgcaa tagatgtgca
    53881 ttaataaaat aaatgcctat aaaaattgaa ttttcaattt ttataggcat ttgtctttta
    53941 ttcagttagt atttcaacac ctgtttctgt aactaaaacc atacattccc attgagcaga
    54001 taatttacca tcttttgtat aaatagtcca attattttct tcatcaacaa aaatttcgtg
    54061 agttccttca tttaccatag gttctattgt gaatatcatc ccaggaacca atagcatctt
    54121 agtccctttt ttagatacat aacttacaaa agggtcttca tgaaagctta atccaactcc
    54181 atgaccacct atttctctaa caacagagta tccatttttc tttgcataag agttgatagc
    54241 atcacctata tctcctaaaa atccccatgg tttggcaact tcaagacctt tttggacaca
    54301 ttcctttgta acttgaacta atttttttgc attttcatta acattaccta tcataaacat
    54361 tcttgaagca tctgaatagt atccattaaa aatagtagaa acatctacat ttataatatc
    54421 tccatctttt aagataatgt ccttacttgg aataccatga caaacttcat tatttactga
    54481 tgtacataca cttttaggaa atccattata gtctagtgga gcagggatag ctccattttg
    54541 tagtgtaaag tcatgaacca acttatttat atcttctgta gacattccaa tttcgatttt
    54601 atctgaaata taatccaaaa tttttgtgtt tattacagca ctttttttta tttcctcaat
    54661 ttgactttca ttttttataa tatcatgagt tggtacaata tgacctaact tagcaaatga
    54721 atctatttta ttatccatat ccatatgaca ttttttatat tttttagtac ttccacacca
    54781 acagctatca tttctattta acttcataac ttttcatcct tcttttatta tttatttaaa
    54841 ttatgggtta cataaactat tttaaaacat aaccattata aatattataa cataaatact
    54901 aagaaatcct ttatagatag tgatttattc aaagtataaa ttattatatg gttattgttg
    54961 atgaaaagag gatagttaaa tgtattattg gatattagcg cacttaatag tttaattcaa
    55021 gtttttcaag aaaatcatat gttagaggac aattttcctt taaagtattt tttgaatctt
    55081 catcaagata ataatgcaca aatgattctg caaaaaattc ttctataaac ttgcttatat
    55141 atgcatgtgc aacttgctta gggtcataaa gcttatatct ttcctgagca aatacttcca
    55201 taaattcttc agaatttgat tttttattta aaacattttt atctatagca tgtgcagttt
    55261 catgtaattc taaatttttt gatgaatgta catttgcata gctagggtta ctataaccta
    55321 ttttagccac tatagaatta tttctatata taccaggtac atctttccaa gtcttgcctg
    55381 atcttaccca acatggaggt aattgatatt ttaaatcact aaattctggt tcatcagtta
    55441 gatttgaatt tattaatttt atttttatat ccttttcttt aagtgtctgt aaatatttaa
    55501 tatttatttt tgcaagtctg tttttcatat tttcaacttc atctttatca taattcaagt
    55561 catcaggaag tataagcatt tgttcaatta tatctatact actgtctttt atattttcag
    55621 attcttcatt aaatttatat tgaagagtat tattttcata gatagttata tttgtattat
    55681 tttctataga ataagagtga atatcctcta aatctaaaat attcatttgt tgtaaaatat
    55741 gttttgtttc gccactccat actactaaag aaagtgaatt aaaattaatt agtggatttt
    55801 cttttgcttt tatatcattg cttatatcta catcaaatac atattcaatt gagtcttcta
    55861 tgttaagact atctgtattc tttttaatat ataaatacgc ttgttttaag tctatataaa
    55921 tctcatctaa agattcgtca taaaattctg ataaattatt agtaaagagt tcttcactta
    55981 aaagttcatt tttatcagtt atactttcaa ttaaaatatt aatttctttt atcatatcgt
    56041 aaatacttat ttttctattt gctttttcac tagatacatt gcatggcgca agagcaatgc
    56101 aataaaaatc tttttctttt ttataaaagg ctttaagtga ttttgataaa agtgtaaagt
    56161 ctacacctat ctgtaagttg accttaagtg agtcattttg taataattca gtattatttc
    56221 ttttagctgt atttaaattg ttttccataa tcattgcccc ctttttatta gggtatcata
    56281 atttttttat atgtgtcaat ttgttttttt gaaaattata atttttttga aaattttatt
    56341 ttttataatt tgtgaatttt ttattataga aataaatatg ttattattat gtcaaaattt
    56401 agcattagat tcatgtagag tatgttttat acatatatta taattaattc tttgaagatt
    56461 gcatattcaa aatacacacc atttttttta attctataat ataatattta tatatttaat
    56521 gttaggatgt gatttaaggt gtattttaca tatattataa gatgtaaaga tgattctcta
    56581 tacactggat ataccagtaa tatagttaga agaatgaatg aacataaatt aggaattaat
    56641 tcaaaataca caagagcaaa gggatttgaa aaactagaag tttattttgt gaccaacaca
    56701 aaaagcaatg ctatgaagtt agaatactat ataaaaaaat taactagaaa taaaaaattg
    56761 tctataataa aaaacccaag tatacttata aatttaattg ataataaaga agattatatt
    56821 attggtaagg aaatagaaca attaacataa atatttatag taacattata atgggtgcat
    56881 atggtgtaaa aacttgacaa taaatactat tgtaatataa tgaagttata aatatagtaa
    56941 attaaaatag ctaggggagc caagagctga gaggtatacc gacccttaca cctgatctgg
    57001 ataataccag cgtaggaaag cttagtaaaa attcaagtat gtattatttg tgatatatgc
    57061 tatttctaag ctatacctat tgtaggtata gcttttttaa ttaagttatt taaattaaac
    57121 tttaggaggc aacaatgagt aattataaaa taccaacact tacaatagcc ggctctgatt
    57181 catctggagg agctgggatt caggctgatt tgaaaacgtt tagtgcaatt ggtacttatg
    57241 gtatgagtgt aataacagct ataacagcac agaatactaa aggagttttt gctgtagagg
    57301 atttaaataa gaaaataata aaaaaacaaa tagaggcagt ctttgaagat atacctccaa
    57361 gagctgtaaa aataggaatg gtttcaagtc ctgagattat acttgaaata gttgagaatc
    57421 taaagaaata caatccaaaa tatttggttg tggacccagt aatgatatct aaaagtggat
    57481 attatctatt aaagccagag gcaaaagaaa acttaattaa gtatttgata ccacttgcat
    57541 acataattac accaaatata ccagaggcag aagaaataac aggaataaaa atacataatg
    57601 tagatgatat gaagagagta ggagaagaaa tactacaact tggacctaaa tttgtactta
    57661 tgaaaggagg tcatttagat ggagaagcag tggatatttt agttggtaaa aatatattta
    57721 aagtttataa aagtgaaaga attgataaaa aaaatacaca tggaacaggg tgcacattat
    57781 cttctgcaat aacatcttat ctagcattag gatatgaaat aacagaagca gtaaatctaa
    57841 gtaaaatcta tataacagaa gcaataaaaa gaagttttga tataggtcat ggagtaggac
    57901 cagtacatca tttttataaa tttgagtaat aaaaaaatat tggaggtaga atatgtataa
    57961 tttaattaaa gatgtaaaaa aattaaatcc attggtaatt cattatacta ataatgtaac
    58021 tataaatgat tgtgctaatg taactttagc tgtaggagca agtcctctta tgagtttttc
    58081 atatgaggaa gtagaagaaa tggtaagtgt agcaaactct gtagtaataa atataggaac
    58141 tatgaactca aatatgttgg atttattcct attagctgga aaagcagcaa ataagtacaa
    58201 taaacctgtt gttttggacc cagttggagt atttgcaagc aaagcgagag cagaacttac
    58261 aagtagactt ttaaatgaag tcaaatttag tgttgttaaa gggaatgtat cagaaataaa
    58321 gtttataggt ggctttaatg taaagggtaa aggtgtagat tcatttgatg aagaagaaga
    58381 ttctactgag ataataagaa agattgctga aaagcttgaa tgtgtagttg tagcaactgg
    58441 aaaaatagat ataataacta atggtaaagg tacatataaa ataaacaatg gaactgataa
    58501 attaaaagga attacaggaa ctggatgtat gactgctagc ttgattgcaa gttttatggc
    58561 tgttactgag aatatattag aagcagcaac aatgggtgtt cttacaatgt ctttaagtgg
    58621 ggaattagct aatttaaata atccaccaat aggtacattt aaagaaaatc ttatgaatgc
    58681 tatttatcaa atggatatag atactttaag taaaaattct aatattgaat ttttaaatta
    58741 ataaagagta agggagactt aaaatgattg ataaagaatc tttaaaaaaa tgtttaaagt
    58801 tgtatttagt aactgactct gaaatgctta aaggtagaga cttttataaa tgtcttgaag
    58861 atgcaatatc ttctggaata acaactgtac aacttagaga aaaaaatgct tctggaagag
    58921 agtttttaag aaaagctatg aaacttagag aaataactaa aagatatggt gttaagttta
    58981 taataaatga tagagtggat atagcactta tttgtgatgc agatggagta catgtaggac
    59041 agagtgacat tgatgttaga gaggttagaa agcttatagg aaacaataaa attctaggag
    59101 tatcagcaag aactttagaa gaagctattt gtgcaaaaaa tgatggcgca gactatttag
    59161 gtgtagggtc tatattcaca acatctacta aattagatgc aaaatcagct tcgtttgaaa
    59221 ctgttaaaga aattaaagaa aaagtagaca tgccatttgt actaattgga ggtataaatt
    59281 tagacaatat agataaactt aaatgtttag aaagtgacgg gtatgctata atatcagcta
    59341 tattaaaagc tgaagatatc tctaaagaag tggaaaagtg gacattaaaa atataaaatt
    59401 ggctctggta gtgaaaaaaa tggaaaaatt tgatataatc taagagtaaa atttaagcaa
    59461 ttataaatga taaacttttc tacatatact ttttaatcaa gatatatgta gatttggtta
    59521 aaaaggagct ataaatgatt aggatattgt tagtgtgtgt tggaggcatg tcttctaccc
    59581 tattggtaaa taaaatggag aaggatgcaa aaaaaagaaa tatagactgt aaaatatggg
    59641 cagttggaga aggagatata aaatcggagc ttgataactt tgatatttta cttcttggac
    59701 cacaacttag atttatgctt gatgacgtaa agtctatagt tggagataga gctccagtat
    59761 ctataataga tatggtaaac tatggcactt gtaatggtca tgctgtgtta aattcggttt
    59821 tagaaatatt aaaataaata ataaaaatgg attctatata atagagtcca tttttattat
    59881 ttgttattaa taggcttaaa acttagctta ccatttcttt ttttaatctc cacatagcaa
    59941 gtgaaaaact tgaacagcat aatattaaaa atagtaggat aacaggcatt atatctccaa
    60001 taagaatagt ctcaccaaat attaagctac gtaaagcgtt aataacatgg gtaaatggat
    60061 tgagcatcac tgctactttt aatcctccag ataaactttc tatagggaaa agagctgaac
    60121 ttaaaaagaa aataggaagt acaattgcag tcataattgt ttcataaact atttcatttg
    60181 gcaataataa acttatagaa taagctagac ttgataaaaa gaaggctgtc ataaatatca
    60241 gtactatcat aagtaggatt ccaccaatgc cagattctat ccttactgag aagaatatac
    60301 ttactataca caaaatagtt acttctatga aagaaactaa gatagcttct aataattgac
    60361 caaggacgat tgaataccta ctgataggtg caattaagac tctatagaaa cttccactgt
    60421 tcttcattat aaagtttata ataccaccac tactacaaga agaaaacaca accagtacaa
    60481 tgatacctgg tagtataaaa gcagtataat tattgatatt tatattattc atagtttggt
    60541 ttgcaataga actataaagc acaagccaaa gaaaaggttg taatatagta actacaaatg
    60601 agattggatt tttaaaacgc cacttcatac tacgccataa gatatttaac attcccattc
    60661 ctcctttaag ctttttttag aacttgtaag tgctaaaaat acatcttcga gacttggctc
    60721 tacaatttct attgcatcaa attctatatc atgttctaaa agccatttat ttattaaagt
    60781 aaaagcagtt ctactatcgt ttacacttat aaaaattgaa ttttctcgta cgctcataaa
    60841 ctttactaaa ccagtacttt taattgcatc tttatatttt tttatatctt cagtattatg
    60901 gaaagttata cgtagtatat tttgtctaat gtaactacgt aaacttgatg gtgttccttg
    60961 tgctaaatcc tttccattct tcataataca aatattatca ctcaattgtt cagcttcttc
    61021 aagataatga gtagttagaa atatagttgt gccatactca tctctaattt ttaataacat
    61081 atcccacata gattttcttg aatcgacatc cataccaaca gttggttcat ctaaaaatag
    61141 gattttagga gatgatacca tattcatagc tatgtccaat ctacgtttta caccccctga
    61201 atatgatgaa gtaggatatt ttaagtaact agataagtca aacttatcaa ttaaagagtc
    61261 tattctttgt tttgcaatct gtggttctac tttatacatt ttactttgaa ataccatatt
    61321 ttccataagg gataaatgtt catcaataga gatttgctgt gctacacaag caatttgagt
    61381 acgtatccaa gaaggattat ctactaaatc ttttccaaac attgttacat ttccagatgt
    61441 aggtttgtaa aaggtagtca aaatatttat aagagaagat ttaccagcac cattaggacc
    61501 aagtaaagaa aaaatttctc cagcatttac attaaagctt agagcattta aagctttcac
    61561 accattttta tattctttta ctaaattgtc tatttcaatc gctaacatat attattcctc
    61621 ctctttaagt ggaaatatta tctctgtaat atagttatct gggtttcctt ttatcaacat
    61681 acctggtcct ttaataaata cttctctcca aggagtttgt atttttatat tattttcatg
    61741 aatatattta aatatcattt catacgtttt tggaaaatta ctataagagc ctgtgtgagt
    61801 aaaaaataaa gcttttgttt taggaaattc ttttgtagtt atacccatac gatttggagt
    61861 ttcagcagtt ggaacacata attccatttc tgcaacacca gttttttggt caacatcata
    61921 gtagcaaaag aatggtgcac cgttagactt tccttttata gctttaaata catttggaaa
    61981 atactttgtt gcctcagtca taggtccatt ataacgcatg gtagccactg tgactgattc
    62041 gatatttttg atttcaattt tgcaattcat tgtttacctc ctaatgtgtg ttcatattct
    62101 tactagattt ttaagcatta atacatataa gattttgatt agttgaaaac atataatctt
    62161 atctcgtttg cttgttttca agtctaacat aacataaaat atatatcctc tcatttgatg
    62221 ctccattttg taaagttatt atttaagctt tactttagat tttttagcaa attaaaataa
    62281 agcaatttat aaaataagta tttacaaatt aagtgtatta atcgtataat acacttaata
    62341 ggatactaga taaagtctga aataaaggcg tattttttta aagtaagtgt actatcgtat
    62401 taatacacta gaataggagg aatcatgaat tttgaattag ataatacaac tcccatttat
    62461 ttgcaaatag taaagtatat aaagagacaa atagtaacag gagagttgaa accaggagag
    62521 acaataccat caagaagaga aatggcactt aatctaaaag taaacttaaa tacagttcaa
    62581 agagcatata aggagatggg tgatatgaat ataataaata cttttaaaaa ttatcaaagc
    62641 agtgtaacag ttgatgaaaa tatattaaaa aatttaaaat tagagcttat aaatgaatca
    62701 ctatctgttt ttatagaaga tatgaaagca ataaatgtta gcaaagaaga agttttaaaa
    62761 ataatagaag ataagtatta gttttttaac aaatagaaaa cttagtttag aaagtttatt
    62821 tataagcata ttggatgtgg aggatagtaa atatgataga aataaagaat gtcagcaaaa
    62881 catataaaag gatgcaaggg cttaaaataa gaaagataga agctttaaaa aatgtaagtt
    62941 ttaatataga aaagggaaaa ataactgcat tacttggtat aaatggtgtt ggtaaatcaa
    63001 ctatgttaaa agcaatagca ggacttataa acattgatag tggagaaatt cgtatagatg
    63061 gagaaaaaat aaatgaaaag gtatacaata aattggcttt tgttccagat gtacaatctc
    63121 actttagcaa tacaacaata aaagaaacat ttgaatttat ggaaattttt tattcaaagt
    63181 ggaataaaga aaaatcaaaa gaaatgatgg acatatttaa attggatgaa gatgaaataa
    63241 ttgataactt gtcaaaagga aacattgcaa gagtaaaatt aatacttgga ttttgccaag
    63301 acccagagta catacttctt gatgaaccat ttacaggaat tgatttgttt aagagggaag
    63361 agtttatagg agtaatagcg caatatatgg aggaaaatca agccattatc ataactactc
    63421 atgagatagt agagatagaa agtttagttg atgaggttgt aattcttgat gaagggcaga
    63481 ttataacttc atttaatgca gaagaattaa gagaaagaga aggtaaatct atattagata
    63541 agatgaggga ggtatataag aatgaataaa cttctatatc taataaatgt agatttgaga
    63601 agaagcaata agttttatat agcttatata tcattttttt cactaattac acttagttta
    63661 aatttattcg aaattaataa atttaaaaat tctaaattta ttatgaactt agcaatagaa
    63721 gattttggag gtatatttta tggactaggg atacttagta atcttggttt tatccaaagt
    63781 atattgttct ttgggatatt gggacttttt atatactata tttttatgtg gaaaagagag
    63841 ttcttttcaa ataatcaaag tatttataca cttatgatgt tacctcaaaa taagtttaag
    63901 atttgtatat ctaaatcaat agctttgata acaatgatat atggtttttt gataagtcag
    63961 acagcaacat tatttatatg taaatatata tttaatttca tttttagaaa tatgcctata
    64021 atcaatatga actttgccaa agatttatat tatttaaact tgaagagtat accaattgat
    64081 tttatctctt ttatggctat ctatgtattt ttactactta tagctatttc tattgtaaat
    64141 tgctgtatat tatttatctt ttcctatata aataaatttt atgtaatttt aatcactttg
    64201 ctgattatag caggcttata tttttcaaca atatatataa atataatcac tttatttaga
    64261 aaatattata gtcttatagg atttcaattt aacaatttag tagcagggtt attaagtttt
    64321 ttaattataa tgtttattct aaatggaata tcttatttgc taattaaaaa gaaagtatct
    64381 ctttaaggag gggtggtatg aaattaaaat ctaaaatatc tatacttatt atatttttga
    64441 ctttagcaat atattttagt ataggtttat taaataatga agataattta aagataaaaa
    64501 ctataaaagg tgactctaat gaattagacc atataaacat aaattttgga tatgctttga
    64561 atggatatat aaattcatat tatacaataa atggaagtaa caaaaccaaa aagactgaat
    64621 taataaaact acaaaaggat agtaagaaca caaataattt aattgatgta tctagtggtt
    64681 cagatttaat tgcacatgtt ggatttgaaa tgaatgagga gtcaaaagat ataaactttg
    64741 taatagatga gaaaaaagaa gatttagaaa aaggtgtatt tccatcagaa ggaagtgata
    64801 aagaaattga atatgaaaaa ttagatatga ataattttac aaggacaaga tataaagtag
    64861 ataaaagtac agatgattat tatgcaaata tactagcatc aaaaagatat aaaaaatact
    64921 tatatgtatc tgtactttat gctacaagtg attcatcaga aaataacaaa gaatattcaa
    64981 gtactataga tataataaaa attaatccag aaaataaaaa aatcaagact ataaaaagta
    65041 taaatttaag taattatttt tccgaaaaat accaaaacat agagaccata ggtgtaagtt
    65101 atgctagcaa atatgaggat aagatgtata ttttagtaaa tgtactaaat acaaacatag
    65161 gtgataatag taattctaaa tttcatttac ttgagtataa tcttgaagaa aataaggaaa
    65221 gcataatgga attaaaaact gatagcaaaa tggctttagc aaaagcaaag ttagaagcta
    65281 ataaattata tatggtaatg tcgaatgatt atgataatag ttcaattaca gagttaaatt
    65341 tacttaccta taatatatta gataaaagct tagatgaaga taaatatgtt ttagataata
    65401 gagaaaaaag aggaattaga agtattgaaa ttgattcaaa taaaatcgtt gcatatacat
    65461 caaggctaaa ctctatatta tcttgggata ataaatttat gctatatata ataaataaaa
    65521 attctaagga aattgtatat gaaggagaat tacaatttaa cagttcaaat agtatgttag
    65581 aatttgaaat aaagtaggtg agttgatgaa agatttaata agattattcg aatttgaact
    65641 aaaaagaaat ataaagaatt atatatttat aataatttgt tgttgttctt ttgtaatttt
    65701 aaacatagta aaaaatttaa atgactataa ttacataata gaaaatgcag ttaaaagtga
    65761 acagttaaca aaaatcggaa atacgataga aacggtaaag gttacaggtt tctcaagctt
    65821 tagaaatata atgggttcta cagaatcgtg gtttatgttt ggtataattg catgtatttg
    65881 ctatgctttt tttatttggt atagagactt taatggtaga agtaaatcta tatatacact
    65941 tataatgcta cctaaaaata gaatcaatat ttatatatct aaattattaa atatattatt
    66001 tctagtgtat agctatacag tagtacttac aatatctttg tttattgcaa gtaagttgtt
    66061 gcctagacat atgcttggta atgtcacaaa ctatggtttt gtacaagaaa caatatatga
    66121 gttaaaaatg ttacttccat atagctttga aatactattt gtagagtata tatttttatt
    66181 gataggattt gtatctgtag tatttacatc aattcttata aataaatcta tttataaagt
    66241 aagcacttta ataagttttc tatttttagt tatagaaatt ttagtgttta taatttctat
    66301 agaatttatt ataccctacg aatacagtga tgtatttact gttctatatt caagtataaa
    66361 catatttgta tgtagtctta tatctaataa acttttgaag caaaagattg acttttagga
    66421 gggatattat gaaagcaaaa aatataggaa aatatacaat atgttttata atagtatgtt
    66481 ttttaatgat tactatgacc ttaatattga gttattttaa taaggataaa ctatctgtaa
    66541 aaactttaaa aggcaatgta aaagatatag ggagagtaag tgtagtatat acacctaata
    66601 taagcaaatt ttcttatgag gaggtaatta taagtaaaaa tggagtaaga aataatacaa
    66661 acccaaaatc aagaattaga aatgattatt taaatattga caaaaaatac agtgactttg
    66721 ttaatgataa aggaaaagaa tttatatata aagatgattt gaatatagga gaagcgtata
    66781 cctctgttaa gtctgattta gtacaaggaa tgaatgcttt aaatgattgt ataaaggttt
    66841 caaataaaaa tttaaaaagt ggggtagaag aaaattttga tattaattta aataagtctg
    66901 attttaaaga aaatagttgg aaaaccttat ttaacaaaat atataaaggt aatttatata
    66961 tggtaattag tgaaactaat atttcaggtt ctaaagtcaa taatatttgt atactaaaga
    67021 tagatataaa aaataagtct tataaattat taaatagatt taatttagga ttacagaatg
    67081 gagaacaaca aaatatcaat gaaattaaat tttctattgg aagtaaatta tacttagaaa
    67141 tagtaaataa taaaagtaaa aatggatata ttgaaggaca tgatagt
//
LOCUS       DAEQCW010000009        65722 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.009, whole genome shotgun sequence.
ACCESSION   DAEQCW010000009 DAEQCW010000000
VERSION     DAEQCW010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 65722)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 65722)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..65722
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.009"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            519..3161
                     /gene="adhE"
                     /locus_tag="KRO40_000628"
                     /gene_synonym="adhC"
     CDS             519..3161
                     /gene="adhE"
                     /locus_tag="KRO40_000628"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBH2091467.1"
                     /translation="MEKKEKVVEKSNVEVCSPEIVNSVETLRMRLEEIRLAQKEFATF
                     TQEQVDKIFLAASTAANQQRIPLAKMAVEETGMGIVEDKVIKNHFASEYIYNAYKDTK
                     TCGVIEKDEAFGFTRIAEPVGVLSAVIPTTNPTSTAIFKSLIALKTRNGIIFSPHPRA
                     KNCTIEAARVVHDAAVKAGAPKGLIGWVDVPSIELTNVVMAEADLILATGGPGMVKSA
                     YSSGKPAVGVGPGNVPAIIDESADIKMAVSSILVSKSFDNGMICASEQAVIVPEKIYE
                     EVKKEFKYRGAHFLNKEETEKVGKVVIIDGSLNARIVGQPAHVIAKMADVEVPKTARI
                     IIGEVESVELNEPFAHEKLSPVLAMYKSKSFEDAVAKAEKLVADGGYGHTSSLYADSI
                     NHPERVEKFVNAMKTCRVLVNTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVSENVG
                     VKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVAAREFKDVMDKKKAFIVTDSFLY
                     NNGYTKKLTDLLDEMGIKHTTFFDVAPDPTLACAREGAKAMADFQPDLIIAVGGGSAM
                     DAGKIMWVMYEHPEVDFQDLAMRFMDIRKRVYVFPKMGEKAYFAAIPTSAGTGSEVTP
                     FAVITDQDSGVKYPLADYELMPNMAIIDADMMMEMPPRLTAASGVDALTHALEAYVSM
                     LRTEPADGLALQAGKIIFEYLPRAYKNGKNDKEAREKMAMASTMAGMSFANAFLGICH
                     SLAHKLGAFHHVQHGVANALLINEVIKFNCAEAPNKMGAFSQYRYPDCIQRYAEFASF
                     AGIKGSTDQEKVDNLIKAIDELKAKVGLPKTIKEAGVEESKFLERLDAMVEQAFDDQC
                     TGANPRYPLMSELKEIYLKVYYGK"
     gene            complement(3521..3862)
                     /locus_tag="KRO40_000629"
     CDS             complement(3521..3862)
                     /locus_tag="KRO40_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091468.1"
                     /translation="MLLILGNLNLNLDFDYRIIREENEDVDIFIDINYRSLDIDTDGS
                     NLFNSRIQFPFVRALILRLNKNNQCMTIHLLRDIDLFSAFANFEVDYTDSIINIKNQN
                     EKVILNKSIKK"
     gene            complement(3889..4560)
                     /locus_tag="KRO40_000630"
     CDS             complement(3889..4560)
                     /locus_tag="KRO40_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091469.1"
                     /translation="MPILETINLGKIYGKKETSVHALKNANLKINKGEFVAIIGPSGS
                     GKSTFLHLVGGLERPSNGTIKVDGKDICCLSDKELARYRRQKVGFVFQQYNLIPVLNV
                     KENIELPLKLDNKKIDKEYIDDLINLLGLNERKNHLPNQLSGGQQQRVAIARALSAKP
                     SIILADEPTGNLDSKTTEEVMDLLKSSIKKYNQTLIIITHNENIARKADRIISIIDGE
                     LKLTL"
     gene            complement(4572..7148)
                     /locus_tag="KRO40_000631"
     CDS             complement(4572..7148)
                     /locus_tag="KRO40_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2091470.1"
                     /translation="MKDNLKIVLRYIKSYKARSLAIVVSIILATSLVVGIGTLSRSAQ
                     QADVDRLKRELGTDHVYFKNIKKNQLKSIKSSKDIKNLGITSYYASTDVNEKLPINIL
                     YTNKNYLTSHSKLIKGRFPKASNEVVVEKWILNSMGLKPEINQNLTFKLYQKENPETF
                     KVVGILEDRFIEKKKGQCEIFSNLNESELNDFTTYIEFNEGSDINTNIDNIIKNAMLD
                     EKSIGRNSMLIESTMKNGTLDNSSKYVAIAMSLFAGIVIYSIYVISIYQRVQEYGVLR
                     AIGSTNFRIFKLMLYELFILALIAMPIGICIGMGGAQIFNRSVGNIQFEGNINVTPFV
                     IPDKIILLSIACTILIILIISFFTYLKIRRISPIDAIRKTFGADKNVTKVNYLISKLT
                     LNMSVTKSISAKNIFRNKKGFIIIVLSMSIGGIIVIKDNYKYSFLDVQNKSTQEQTYM
                     NADFILSNVYLNEIGNNTSFKDIKGFNDNQIDKIKNIDGIDKVKTASILNTRIEVNKI
                     NRLDYYEAINSTPYYKLNPLFIKNKTTGKYTLKQKLKGYNDEMIKSLEKYLVSGNINL
                     KKMKKENLAIVYVPEISKTQKYTKTFTPGEGTPAVDIKVGDTIKVKYPKGGMDTGLYE
                     SLKDNYEYLEYEFKVGAIISYPFADNGMYSGDDGVDVITSSEYLKKLTGVDKYNLVYA
                     DLNENANKKKINNLLGKIGSEVPGTTTVDMMVEKENSDKMTSRTMIYSYGIVAIMFII
                     SVLNIINNISYNLTSRTSEFGMLRAIGISERGFKNMILYEGILYGVLSSIITIVSGII
                     IQFKMYYMQGFVSYGLGFSIDYKIYILVVVANIIVGILATYIPSRKINKISIVEAINI
                     TE"
     gene            7356..8291
                     /locus_tag="KRO40_000632"
     CDS             7356..8291
                     /locus_tag="KRO40_000632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2091471.1"
                     /translation="MDNNFVFPIVILTLFIFSNLIMNKYKFYKELDILKRGILTFFIS
                     CFALILFMEGTKYIQLRLGYSFLLEGVLNIILFLVLIILSFYTGFKVIRLINNNNEQE
                     YKLQKLDSKINHKDNIIIKLRSQKHDYLKHLQVVYSLLNTGLDEDAKEYIMNISNSFK
                     SKNSRYGKVSYLDAIASLKYEECLEKDISFDVYIQDFMDNLEIEPNDMSSVLLNIIDN
                     AIESLSTIKKEKKYIRLHAYEDEFQYIIAIKNNGPKIHNVESIFWNGFSTKEGQDRGY
                     GLHLVKNILDKYDYSILVNSDDFLTEFVILIPKYY"
     gene            8310..9047
                     /locus_tag="KRO40_000633"
     CDS             8310..9047
                     /locus_tag="KRO40_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091472.1"
                     /translation="MIKVLICDDDKIVRDDIANIAKESGYVDYVKKVKDGIEAIEFIK
                     NEKIDLLIIDIDMPYKNGIDSAEEILSIDKDIHIVFVTGFADYSLESFKVHPIDFVVK
                     PFKKEKILDSINIAIDHINSHKIANNNFIEDTLFVYKIRKQIHMINFDDIVMFEKNSR
                     AINLHTKDEDIIKFYENFDDLKKRLPPNFFMTHRQYIVNLRFIHKVIPINKSSLEIRF
                     INFQENAILNKSLEKDFLYRFYRVKRF"
     gene            complement(9232..14289)
                     /locus_tag="KRO40_000634"
     CDS             complement(9232..14289)
                     /locus_tag="KRO40_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4132 domain-containing protein"
                     /protein_id="HBH2091473.1"
                     /translation="MLERTRVEKNPKIIENFKNNFTKSSSKQYYDLAKSLWDCIENSS
                     YYYREPEDKFLNMIKKYYNCHYYEIKNMDELLSGPLKNALELIFTSEQVEELCQLIKR
                     KMDYTYSGGYYRKGYRSNKLVDYFRGIIRFISNYVDLIYYDFSVIDYLTLPNKVLYYD
                     SIMSDKIALEIDKGNQKVISALEEVIFGENQTALLTRQMIIGIMKSHSDKCYEMLSKL
                     LLAAKQQEGLRQQIVESLDEGTISASIYMLKTILDNNLERFSSVIRALDTWTGLGFSD
                     QKPGIIRKCLELSYKSLTDEKFRIESINSNDNLEIYFALWATATYNIYDSYSLIENLL
                     SCQEKYKKLVALYFLSHTESTYFKHSIASKNIKGDDLEILAWVITNFYVEGSVGYYYS
                     WQNRETNFDLSNTPIDKDFDARKEQFESLKHTLEILNSKTKSFSGSVFPWTWIEISSH
                     EILKCMMTLTAYDMNAQFIDVLMENCHLMSSDLRASLIVNFVNEPKTDRQREFLLECL
                     SDKSVSNRETVLSLLRKLELTDVELDKITNLLSLKTSSIRQTVIKILLEQDDSNLENI
                     ASSLIKSSNSQKCLGGLEIVNLLKDNTARQELYNKLILLIEDIDKSKKNTSQVQILID
                     NLLGKAKNDYCKENGFGIYNPENKVQIPEQFDFKDDSNSSSKLNKIISNISLSTREDS
                     VSVATKKEAKKILDTDINKIIKVYEKFDELITENADYEYEVERWSGNVDKVLLGYSTY
                     NLTPIKYKVSNDTLDNYPLAELWRETSKKLDLDYKLILDILFYSISTCGYNETEKSWF
                     SSIYSNVLDSKKQNKIYTKLEKLKFNGLTRKLLRVLLNEFDHKEIFNYCLEIYYKLRN
                     LLTIEQCKKQRVEFTKNYYRQNEYCPALNAPILNYWLDKAHSFIYDDISFTKFFYTTF
                     SNYQLLEYKFPFYTSINVFARAHELGLMTEEQVNREMISGYNASNIIRTLTNPRWAGD
                     TLEKYPWLKDNLKTVTNRIIEIESRRGDMPTEVSNLANNIQYFEGINYFVNILVALGK
                     ETFQRGYSYGSNYSKKDVLSSLLKNCYPTKEDDSKKLKSLLKNTDITELRLIESAMYA
                     PQWVNIIEKYLNWKGLKSTIWYFHAHINEGFSAQKESEVALFSPISPRSFIDGAFDVD
                     WFLDSYKTIGEERFNILYKSAKYITSGGNSHRRAQLYADATLGKLDKDMLMKEIETNR
                     NQDKLRSFSLLPMKKGDLKEATFRYEFIQKFAKESKQFGAQRRESESKACTIALENLA
                     RSAGFGDVNRMMWALETEKLNEVAHLFKPKDIDGTSIWIDVDENGKASTKVQKGNKSL
                     KSIPKAIAKHPYVLELKSVQKDLKSQYSRAKQSLEQAMKNEIVFTVKEIANIYKNPVI
                     CPLIKNLVWVCDDNIGYVYNDKSKFFICNIEGETYKLTAKNKLKLAHPVHLFESGKWS
                     EFQHDLFSKQIVQPFKQVFREYYRINSDELSEKTISRRYAGHQIQPKKTVALLRNQLW
                     TVDYEEGLQKVFYKENIVAKMFALADWFSPADIEPPTIETVEFFDRKTYKSLELASIP
                     PILFSEVMRDIDLVVSVAHAGGVDPETSHSTVEMRIAIAKELLLLLKINNVNFEGSHA
                     LIAGNLGEYSVHMGSGIVHKKGMGALNILPIHSQSRGKIFLPFADEDPKTAEIMSKIL
                     LLAEDSKIKDPSILSNL"
     gene            complement(14314..14733)
                     /locus_tag="KRO40_000635"
     CDS             complement(14314..14733)
                     /locus_tag="KRO40_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091474.1"
                     /translation="MQIYFRVKAVGKRKPMLELTPFDVSDNINCLKEAISEIVSKNVL
                     EYNEKIPEKSIINFLTNEEIESQADIGKVGFGSIYNENKQSVEKAIEVALQAFEDGIY
                     KVLINEDVIEKLDSSINLKSGDIFTFIRLTLLAGRMF"
     gene            complement(14967..15218)
                     /locus_tag="KRO40_000636"
     CDS             complement(14967..15218)
                     /locus_tag="KRO40_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091475.1"
                     /translation="MNRYTKIINMMGSYYTKDFEKEKKNVIKVREVKEDTVRKFFLQG
                     DCEVLVVFEDTGKEILIDDFSPEEDIKKYLGAKFINKKR"
     gene            15307..16038
                     /locus_tag="KRO40_000637"
     CDS             15307..16038
                     /locus_tag="KRO40_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkgJ family cysteine cluster protein"
                     /protein_id="HBH2091476.1"
                     /translation="MTSIKNKDILNCIDYSIKNKLFDKLNDVYKSLPVGNCSGCGNCC
                     MESVGINLIEFLNIFCYLEDRVDLKKSCISKILDYYFEEYTRKNPCPFKDTNNRCLIY
                     EVRPLNCRMFGHWKKEDYNKNLDNVIEKNNNYRELMKKQYGFEINDEVVNYRIDYCDR
                     FIPNKDYLSKSKRLSFFDELMILDSNIYSSGNIDIDFRDRGIVEYFIESLLYRNLAYN
                     VKIRISKEYKIRKRTIDRIKRIVLV"
     gene            16097..17008
                     /locus_tag="KRO40_000638"
     CDS             16097..17008
                     /locus_tag="KRO40_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2091477.1"
                     /translation="MNLTKVKGNTFFIKGGTNTGIYVFEDNTALMIDPGLCGSRPRRV
                     NKVLDENNIQVRYIINTHGHDDHYGACNQFKEYYKDVCIMSSEYDKLYIENPELFSKY
                     IVGGKSNVFMDNILKNKMLDDIKIDKSIEAGKIELNNEMFDIIEFQGHTPGSIAVLTK
                     DNVIFVGDLLIGDEILSKYDFLFLYDIQEQINSLEKLKNIDFEYLVLGHGKQVISKED
                     SYKLIEKHLNALKKYLYQIRELLVEPKSLEILLKNIINNNNLSNNYKEYHFFKSSLVS
                     VISYLVDLEEIGYILENGELLYYTKTK"
     gene            17059..17871
                     /locus_tag="KRO40_000639"
     CDS             17059..17871
                     /locus_tag="KRO40_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HBH2091478.1"
                     /translation="MEYEKWNEILAPYEHAVEELKIKFKNIRKEYLAKGEYSPIEFVT
                     GRTKKISSIISKLKRINAKDIETEIDDIAGIRIMCQFVEDIYAIVDLIKVRNDMTIIG
                     EKDYITNYKDSGYRSYHVIIKYPINSIAGSKEIICEIQIRTLAMNFWATIEHSLKYKY
                     DHYIPETLAERLRRASDAAFLLDQEMSEIREDIMKAQAMYQMKSIAIRDTLNRIQELY
                     DLGDTHKAMQYQRKLDRTETDKNITEILELKQEIDILLEQYKDTKVDDKVVQ"
     gene            17980..18672
                     /locus_tag="KRO40_000640"
     CDS             17980..18672
                     /locus_tag="KRO40_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2091479.1"
                     /translation="MSLYAIGDLHFSTSVNKPMNIFGSNWDGHEKKIIDNWKEVVKEE
                     DMVLVLGDTSWGINLSEAKKDLDIISKLPGQKILIKGNHDYWWTTVTSLNKLYEDMRF
                     IQTNFYEYKDYAICGGRGWICPNDVKFDETDEKVYKREEHRLRLSLESARKSGHSKII
                     VITHYPPTNDKLEESLFTKLFEEYNVEKVIYGHLHGKESFKMGLKGIRNGVEYTLASC
                     DYTEFNLIKVHD"
     gene            18759..19700
                     /locus_tag="KRO40_000641"
     CDS             18759..19700
                     /locus_tag="KRO40_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091480.1"
                     /translation="MRWILVFIFLYLIPLVVIFRNYKNFKRSCIYSSIYVVLATTIMI
                     SNIYMSGLNKIKESMYYHNYISDETYDEKYVSNFKEKESTDLKQDNKKNEEISNNKNL
                     NNKQDRNIQNKESNEEGSNDIKEKNNSDSNVSVNNKSEKQEDNTKENNKYTSKEKNSE
                     DIKKIDMESIGIFKKEIYNIERAALVPMRECIPYTKDIAKNITKLSSIKKDVTNARNK
                     CKEVVKEYENMQIPELSKEKYTETLSNARDDVKKAYELREKSMESALKLINTKSPKYI
                     GKITEYLDLSDKQIESFKNRLNDLKEEINNSETNNIN"
     gene            19737..20894
                     /locus_tag="KRO40_000642"
     CDS             19737..20894
                     /locus_tag="KRO40_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH2091481.1"
                     /translation="MNKQSIGKLNMFFMGITQRNLDNRDFFIELEVIFKSGRKEFKGI
                     AIEEDNKYKFNFKGKSDLYTFNELLKNISKEAENYDGLVFKYVERGTIVVIEGDNKKV
                     NVKYLDNKEEVPKIDEFTASQIKNRDYYVKVGQANALLKEIGVLTKDGKIKNDKIRKY
                     NQIDHFVELIDSILKEIKDKDCITILDCACGKSYLSFVLNFYIKEVLKKNCYFIGIDY
                     SDVVIEASKNMAKNLGYKNMSFIKEDLTNYTPNRDVDLVISLHACDTATDMAIGLGIR
                     AKSEAIVVVPCCHKELLGQYRYEAMEPILKHGVFKARFADLITDGLRTLLLEGNGYDT
                     SVVEYISPLDTPKNLMIRAIKTKTNNDKALKEYKELKSQFGVEPTLEKLIY"
     gene            21046..21606
                     /locus_tag="KRO40_000643"
     CDS             21046..21606
                     /locus_tag="KRO40_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH2091482.1"
                     /translation="MNKLNICIDIDGTITSPYHFLPYLNDIFNKNITEAECITHNWEE
                     LYGSGIRDVYAEFNNKYIHSYDEAKIVEGATEVISTLSKGHNLSFVTARHECLTDVTK
                     NWLSRQGFSDIDVYLLGSDYKVEKARELSCDIFIEDNPLNSVQLADDGVKVILLDTNY
                     NKDVKHQNIVRVSNWIDIEKIIKQGI"
     gene            21634..22125
                     /locus_tag="KRO40_000644"
     CDS             21634..22125
                     /locus_tag="KRO40_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091483.1"
                     /translation="MIDLKIENRKGKIHVKSSEIKDILELRPDFEYVQDISNTINQEN
                     ILVFDCQLTGNSFDMDDLDIEEILEELGEEIDESYFSVLFEDVRAYLKDATDEIEADL
                     QDNYLFDNLRCYFDIYNINQEFTDFKFVFLVSFKDIKISSLANLAKIVSKRQLIGASK
                     FYS"
     gene            22354..22905
                     /locus_tag="KRO40_000645"
     CDS             22354..22905
                     /locus_tag="KRO40_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091484.1"
                     /translation="MQSLNEIIAENLKKIRKEKHLSLDKIAQLSGVSKSMLSQIEKCE
                     VNPTISTLKKITNGLKISFTSLMERQESDIELIQKSDIDHFIEDNGKYISYPIFPFDS
                     KRRFEIFMIEIEEGGNLDSNAELPGTQEFITVFSGEVTIKINGEDYIVSSGNSIRFKA
                     DVSHIYRNSGKGIAKMSMVVYYI"
     gene            22991..23923
                     /locus_tag="KRO40_000646"
     CDS             22991..23923
                     /locus_tag="KRO40_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="HBH2091485.1"
                     /translation="MNNKKAVFFFCSDLKKDPVASNVIKCCEEIMDLNQTDIVIDDNF
                     VLEFKDKNNNLFHFVKTKDVISHNYKYYLPILNRHFRDYDFAGVVNWHEGENAPEHIL
                     TAHTIGDVPTGEFGNSNPRYFKNLINAIEDIKNENLLDEFTTLTEATHWSGTTYGEES
                     KLITEYSVPMLDIEIGSSSDSFNNSIAIQVLAKSLIRVFDCDEPLKTLLCVGGVHFEK
                     SFSDIIKNKEYNISIGHVLPNQWIVSGMYDDESGFEKLEKCINSIEGGIDCIVFHDKL
                     KGTYKEQCRKLGEKLNVPVFKHKILKNPKDLPIW"
     gene            23978..24841
                     /locus_tag="KRO40_000647"
     CDS             23978..24841
                     /locus_tag="KRO40_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH2091486.1"
                     /translation="MILSYFALLIRVVLLAFERVVVRLLGDEEGDIYKNIASSFLFFF
                     IGGVCLLPFSIMDRVSDWSFLIPCYISSLVYSIGSVAYVTSLATGEVSLVTPINSLNS
                     LFLLLLSVIFLGEGLSLAKVAGIIIMIGGVFILKKVSSFLKNVSVIFNNLPCRLMFLY
                     IFLQSVGRVLDKAFFVQVSPILYSTILYFFVGLNLFIFLAFKKKQKIICEIFTNKKGL
                     SILSGAINGYSYLALLIALNNLELSIAEPFSQVSMIITLILAHFIFKENIKEKIPGSI
                     LILIGGWLLLL"
     gene            25088..26950
                     /locus_tag="KRO40_000648"
     CDS             25088..26950
                     /locus_tag="KRO40_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2091487.1"
                     /translation="MNYKKTAIDIIEQVGGSKNILALEHCSTRLRFKLIDRSKVNQDA
                     LKKVQGVMSIVNGAQFQVVIGNSVVDVYDEILKVCPLDTNDSTVKTEEKINLGTRFIE
                     FIINIFQPLIFAIAGAGILKSLLMLLAMFNILKSDSTIYTLLVAISDATFYFLPLMVA
                     VTTANVLKCNRLVAIAAVGYLLLPATTTALSEGVELFGFTIPNIAYNAQVFPAILCVS
                     FLATMEKIFNKYSPKPIRTFFVPMMSLAITVPITLTILGPLGYNVGTIFTTIILFLYN
                     KMGFLVVGLLAAFLPFMVATGMHKALIPYSINTIGKLGYEALYMTSSLAHNISESGAC
                     FAVALRTKDETLKQTALSAGISALMGITEPALYGITLQHKRAMLGVVFSSAISGTFLG
                     LFAVKGFVIVGPGLASMSMFIDPNNGNNLIFASIGFVIAILGSFIITLIIWKEDTNTV
                     ESSIGDVVEEELEEEKEVNILVTPVEGKVIDLSKVNDELFASKTLGDGVAIIPTNGNL
                     YAPCDSEVVMLFETKHAIGLRTKNGAEILIHIGINTVSMNGDGFKTFVKTGDNVKEGD
                     LLIQFDLDKISHANLDSTVMIVNNNGADYAYKVLNQSYGNVKKGSILFDVKGGI"
     gene            26953..28419
                     /locus_tag="KRO40_000649"
     CDS             26953..28419
                     /locus_tag="KRO40_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000110363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBH2091488.1"
                     /translation="MRKFPEGFLWGGATAANQFEGGWNLGGKGWSVSDVAKAHFDADV
                     KDYKSNNEITTKDIEEGLAHPEDEVNYPKRHGSDFYHHYKEDIALMAEMGFKTYRMSI
                     AWSRIFPNGDDKEPNEEGLQFYDDVFDELISYGIEPLVTMSHYEPPLNIVLNYDGWYS
                     RQVINMFVRYVETICERYKNKVKYWLTFNEVDSMIRHPYTTGGLVRDRFKDKNFEEVI
                     FQAMHHQFVASAIATKICHEIIPNSKVGCMLTKLTYYPYTCRPEDVLATQQKMRSIYA
                     YSDTQVFGEYPVYLLSYFKNNNIQIVKEEHDDEIMKKYPVDFISFSYYMSSCEAADTT
                     GLDITPGNTLLAVKNPYLEMSEWGWQIDSIGLRISLIELYDRYRKPLFIVENGLGAKD
                     ILTEDKKVHDQYRINYLKEHFKCMLDAIIEDGVELWGYTSWGCIDLVSESTKQMSKRY
                     GYIYVDADDYGKGTYNRYKKDSFYWYKKVIENNSIDFK"
     gene            28443..29279
                     /locus_tag="KRO40_000650"
     CDS             28443..29279
                     /locus_tag="KRO40_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2091489.1"
                     /translation="MNYIIKKVLNSSVVLVHDAKYNEFILLGKGIGYGKKTGEYICGS
                     NDNQMFVPVENTKSKQFLELMDDIPVDILKITQEIIVEAEKLLNSSFNKNLYLILADH
                     FNFAIERMRKGIKITNRVFWEIKNYYPNEFKVGMVAIYMVEERLGIQLPEEEAANIAF
                     HFANAMASDGNSYDTIKYAKVIGEIINIFVFSLNRTLDKKSMHYMRFITHIKFFVERF
                     FSDSMLSSGDDLLFNQMKRSNPKEMLIALKVRDFLEKKYGKKLTNEEIAFLVVHIARV
                     KQ"
     gene            29845..31428
                     /gene="asnB"
                     /locus_tag="KRO40_000651"
     CDS             29845..31428
                     /gene="asnB"
                     /locus_tag="KRO40_000651"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBH2091490.1"
                     /translation="MINLEEKYLTRKDTYMIKILEYNGHIRNWKVLCEELGIDSSLCR
                     DERERAILVEAYKTWGYDMANHMHGMFAFALWDTVEKKLFCLRDQFGVKPFYYYETEN
                     GKLLYGSSIRKIMEQPGFVKELNEDMLQIYMSFTYVAGENTFFRGVKKLMPGHYLVYQ
                     NKTVCIGRYWKPEFHPDHSKSIEEWTDEIHTTLQKIMPEVKSENETAELFLSGGVDSS
                     YILAMSDIEKTGSCGYEEERFDESKLAQQTANILGCKNSRYIITPEEYFASVPYVMYH
                     MEQPTGDASAIVFAIGCKAAAENTNICYSGEGADEFFGGYNIYHKAECYGENLKTFYI
                     GNTNIMNEGEKRKILKKYNPDVLPIEVVKGIYEETEELDTLTNMSNVDIQIWLEGDIY
                     FNIDKMSTAVGLEVRMPLTDTRIFDIASRIPSEYKVKGKENKIAFRTAASKTLPEEIA
                     FRNKLGFIVPIRIWMADDRYNKDIRDKFNSEIADKFFNIDEINEIFNDYISGNSDNWR
                     KIWMIYTFLVWYEIYFVKC"
     gene            complement(31493..32089)
                     /locus_tag="KRO40_000652"
     CDS             complement(31493..32089)
                     /locus_tag="KRO40_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04100 family radical SAM protein"
                     /protein_id="HBH2091491.1"
                     /translation="MNILYTIENSIYVNITNTCPCSCVFCIRNEKDEVANSGSLWLEH
                     EPSVDEVKEAFNKYNLDDYDEIVFCGYGEPLMRINELIEIAKFIKEKSSIKIRINTNG
                     LSDLIHNKKTAILLKNVIDAVSISLNAPNKEAYNRVTQPKFGEKSFDYMLDFARDCKK
                     YIKEVAFSVVDEISPEEIEESKQLAKKLDIPLRVRHKN"
     gene            complement(32116..32643)
                     /locus_tag="KRO40_000653"
     CDS             complement(32116..32643)
                     /locus_tag="KRO40_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04002 family protein"
                     /protein_id="HBH2091492.1"
                     /translation="MEKMNKVTSKKTTYIVTSALFASIICLTIAYILHIPVGGNNGYV
                     HIGDAFIYLAATILPTNYAIAASAIGAGLADLSTGAAIWVIPTIIIKPILVLFFTSKS
                     DKIINKRNIVASVVAGIVGLVLYMFAEGIIIGSFTSAFVMSLLGLLQPIGSFIVFIIL
                     GMALDKLDFKKRYFN"
     gene            complement(33005..34003)
                     /locus_tag="KRO40_000654"
     CDS             complement(33005..34003)
                     /locus_tag="KRO40_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="HBH2091493.1"
                     /translation="MKILVFGARDYEEPVIKKWSEEHKDVQVDIYPENMTEENVVKAK
                     GYDGISIQQTNYIDNPYIYETLKDAGVKVIASRTAGVDMIHFDLVNENGLIVTNVPSY
                     SPNAIAELAVTQAMNLLRKTPLVKKKVCEGDYRWIAELLGTEVRSITVGVIGTGKIGA
                     TSAKLFKGLGANVIAFDQYPNSDLNDILTYKDSLEDLLKEADLITLHTPLLEGTKHMI
                     NKDTLAIMKDGAYIVNTGRGGLINTGDLIEALESGKIRAAALDTFETEGLFLNKKMNP
                     GELTDPEINKLLSMEQVIFTHHLGFFTSTAIENIVYSSLSSAVEVIKTGTATNRVN"
     gene            34680..35879
                     /gene="hadA"
                     /locus_tag="KRO40_000655"
     CDS             34680..35879
                     /gene="hadA"
                     /locus_tag="KRO40_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocaprenoyl-CoA:2-hydroxyisocaproate
                     CoA-transferase HadA"
                     /protein_id="HBH2091494.1"
                     /translation="MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRV
                     MGGTFKSPASDDENPMFELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQA
                     LEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
                     SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQ
                     YGNEMPLSRENPNSPLMTTYKCKDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYN
                     NIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQSCEDLLDDEQAWAND
                     FLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFK
                     DSKVVRY"
     gene            35918..36718
                     /gene="hadI"
                     /locus_tag="KRO40_000656"
     CDS             35918..36718
                     /gene="hadI"
                     /locus_tag="KRO40_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyisocaproyl-CoA dehydratase activator
                     HadI"
                     /protein_id="HBH2091495.1"
                     /translation="MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLE
                     KLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIGG
                     QDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSI
                     SSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVAR
                     NSGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI"
     gene            36733..37959
                     /gene="hadB"
                     /locus_tag="KRO40_000657"
     CDS             36733..37959
                     /gene="hadB"
                     /locus_tag="KRO40_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     HadB"
                     /protein_id="HBH2091496.1"
                     /translation="MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELA
                     EVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEAL
                     DMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQF
                     EEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYM
                     AVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMK
                     TLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGK
                     CDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQG
                     LVEVMEERKKLNRGEI"
     gene            37959..39086
                     /gene="hadC"
                     /locus_tag="KRO40_000658"
     CDS             37959..39086
                     /gene="hadC"
                     /locus_tag="KRO40_000658"
                     /EC_number="4.2.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     beta"
                     /protein_id="HBH2091497.1"
                     /translation="MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIH
                     AAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTL
                     ICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
                     HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAK
                     LNAMPEEVCSGKKVLLTGILADSKDILDILEDNNISVVADDLAQETRQFRTDVPAGDD
                     ALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPL
                     VRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA"
     gene            39134..40267
                     /locus_tag="KRO40_000659"
     CDS             39134..40267
                     /locus_tag="KRO40_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBH2091498.1"
                     /translation="MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLA
                     DAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTE
                     EQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
                     CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVP
                     KENLLGKEGQGFKIAMGTLEVGRIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKF
                     QNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYYASEIANEVAYKALQ
                     LHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK"
     gene            40300..41085
                     /locus_tag="KRO40_000660"
     CDS             40300..41085
                     /locus_tag="KRO40_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012703997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH2091499.1"
                     /translation="MKILVCVKQVPDTNEVRINKETGTLIRDGVPSILNPDDANALEE
                     ALKIKDEHDDVTITVITMGPPQADFMLRECLAMGADDAILLSDRAFGGADTWATSNTI
                     AAGISKVGDYDIIFAGRQAIDGDTAQVGPQIAEKLDIPQVTYVQDFKIEGKDIIVQRQ
                     LEDGYELIKVSTPVLLTAVKELNTPRYMSVDKIVKAYKHDVKVWTIDDLDVNKEEVGL
                     KASPTKVFRSFTPEPRGKGEILEGKADEIASKIIIGLKQKHII"
     gene            41104..42141
                     /locus_tag="KRO40_000661"
     CDS             41104..42141
                     /locus_tag="KRO40_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH2091500.1"
                     /translation="MNDIKDLSSYKNVWIFAEQREGKIAPVVIELLGEGRKLAKEVDA
                     ELCAILLGKDVDGLAKELITFGADKVYVADDALLEKYTTDAYTKVIKDAIDEIKPEIM
                     LFGATHIGRDLAPRIASRVGTGLTADCTKLEIDPEDKKIKQTRPAFGGNIMATIICPN
                     HRPQMSTVRPGVMDKAEKDETRTGEVIALDYKITQDDIRTTVLETVKTKKDLVSLTDA
                     NVIVSGGLGLGGPEGFEMLKKLADKLGGVVGSSRAAVDAGWIDHSHQVGQTGTTVKPN
                     LYIACGISGAIQHLAGMQSSDFIIAINKNPAAPILEIADYGVVGDLHEIVPMLIEKLD
                     SVDDLLEAIKA"
     gene            42624..44255
                     /locus_tag="KRO40_000662"
     CDS             42624..44255
                     /locus_tag="KRO40_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2091501.1"
                     /translation="MDNNLIGLIEHVENPAILCKESGEIIYCNHLIDSIFSFLDIKKP
                     RNINELDSNFDKTEILTDSKKKIAFRELRMTAHIYNMKDNNNENNIVYLFEKSLISDK
                     VIEDIIEHIDEVVVVFNKDGVIEKMNTVSDEILPFKRTEVLGRNITDLVRQGLVEEPI
                     ILNMLKVKKKIYRNIVYPDGKLIAYTAVPRWDSKGKLTGGVLTGRDISRVIKLESQIK
                     YSDISEDTEYISQSKIMDNIKKVVKRAAASDSSIFINGESGVGKEIIARTIYKYSSRR
                     DKPFIAINCGAIPNELLESEFFGYEEGSFTGAKKKGKKGLFEEANGGTIFLDEIGELP
                     MQMQKKLLRVIQENTITRIGGSKPIKIDVRYISATNISHEDLRNNLKFRQDLYYRLSV
                     IPVKIPPLRERKEDIVPLVNYFLKLYNEKYNREVEVSPKVIELLEEYSWPGNIRELKN
                     IIERFVVLSAKNVIGEDEFNMLINLDMIDNETDDLSPIVVNGIMNLNDAYKIVDQIMI
                     SKAINKYGSITKAAEVIGIYPSTIHRKIKSGHIHV"
     gene            complement(44390..45316)
                     /gene="fba"
                     /locus_tag="KRO40_000663"
     CDS             complement(44390..45316)
                     /gene="fba"
                     /locus_tag="KRO40_000663"
                     /EC_number="4.1.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II fructose-1,6-bisphosphate aldolase"
                     /protein_id="HBH2091502.1"
                     /translation="MALITTKEMFKKAYEGGFAIGAFNISDLEQLQGVLKAAKAKNSY
                     VMIQASMSAVKYAGPHTLVEMVKAASDEIGVDVALHLDHGPNMDAIKTCIDAGFSSVM
                     IDGSHFDFEENVRITKEAVEYAHSKGVVVEAELGVLAGTEDDVTSDVHKYTQPAEAVE
                     FVERTGVDSLAIAIGTSHGAFKFKGEAKLRFDILEEIQSKLPGFPIVLHGASAVDQNA
                     VATCNEFGGNIAGAKGVPVDMLRKASSMAVCKINMDTDLRLAMTAAIRKFLAENPKEF
                     DPRKYIGAGRDAIQAVVESKIDDVLGSANSIN"
     gene            45646..45975
                     /locus_tag="KRO40_000664"
     CDS             45646..45975
                     /locus_tag="KRO40_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1904 domain-containing protein"
                     /protein_id="HBH2091503.1"
                     /translation="MPQIKIRGINENDICKISEKMINDLVEAVKCPRDYFEIECIKSV
                     AIRDGKIADVYPFVEVAWFDRGQEVQDIVARIITDSIRNNLDVESIDLAFTVFEKEKY
                     YENGEHF"
     gene            45975..46697
                     /locus_tag="KRO40_000665"
     CDS             45975..46697
                     /locus_tag="KRO40_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBH2091504.1"
                     /translation="MAKKQRIDKILSNLGYGSRSEIKKYCKQGSVVVNGSEVSNPGTQ
                     VDTENDEILFNGEEVIYREYIYLMMNKPDGYISATTDKYDPTVLDLIDLSYLAFEPFP
                     VGRLDKDTEGLLVLTNDGKLSHRVLSPKKHVPKTYYAKIDGVVTEEDVEAFLEGVVLD
                     DGYKTMPSQLNILKSDDESEIELTIHEGKFHQVKRMFESVGKKVVYLKRLSMGNLKLD
                     ESLELGEYRELTDEEVKLIEER"
     gene            46724..48085
                     /gene="rlmD"
                     /locus_tag="KRO40_000666"
     CDS             46724..48085
                     /gene="rlmD"
                     /locus_tag="KRO40_000666"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBH2091505.1"
                     /translation="MSVKKKDVIEFEVDKMEFGGTSLSQVGDRVIHMKGGISGQKVRA
                     GVKKVRSKKAEVKMIELLENSPLETEETCKHFRECGGCTLLSVPYEKQLEIKEKQVMD
                     LFLKQDLFGFQFLGIEGSPENKYYRNKMEYTFGDEVKNGPLTLGLHKKGKHIDIQTVE
                     ECMLVDEDFSKILVSSVEFFNEKKLPYYRTMNHKGYLRHLVVRKGIHTNEIMVNIVTS
                     SQEDFDMYEFKDMLLGIDLKAELVGVLHTINDGLADAVQCDELRVLYGRDYIQEEILG
                     LKFKISPFSFFQTNTKGAEVLYSIARDFIGDYNDKVVFDLYSGTGSIGQVMAGAAKKV
                     YGIEIVEEAVVAANENAKLNGLTNCEFIAGDVAKVVKDLKDKPDLIIVDPPRPGIHKD
                     AIRDICGFGAKEIVYISCNPKSLVVDLVDFKGYGYEIKMVKCMDMFPNTPHCETVVLL
                     RRK"
     gene            48483..50546
                     /locus_tag="KRO40_000667"
     CDS             48483..50546
                     /locus_tag="KRO40_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2091506.1"
                     /translation="MTKIILSNYRCFGEEPTTIEINNLTGFIGHNSSGKTALLSALMK
                     LFGEKSSDRIIERSDFHIPESIDPDSISKNELYIEAQFEFPELERGKDSISIPVFFKN
                     MVVSEPGGKPYLRIRLEANWEKSSNPEGSIDSNVYYITSTTEEINPEDKRNIKRYELD
                     QIKMIYVPAIRRPDEQLKNVSGTIISRLLNGISWSEQTKARIKTKASETEEIFFEEKG
                     VESLKKSLETQWNSYHKDIRYSNPKINFNSTDLETILKKVEVTFSPTGTHRDYRVEEL
                     GDGLRSLFYLSLVNTFLEIEEEILKSINDGKEEDIFTLIPPVLTIVAVEEPENHISPH
                     LLGRVVEKLNFISTKENSQTILTSHSPAIVKRIEPTDIRYFRICKEYECTKVKSIILP
                     NEEKEAEQFKFVKESVLAYPELYFAKLVVLGEGDSEEIIIKQMIELKAESVDSSEISI
                     VPLGGRHVNHFWRLLNDLEIPFITLLDLDRERDGGGWGRIKYAIQQLINIGHDKNVLL
                     YTCEGISQDNEFKEMHTWDVTDTENMAKWIEMLKGYDVYFSAPLDIDFAMLQSFKDKY
                     ISALTSAEGPRIKDHGKIQDIVINEDAEDESLKAAYKDRIDSDIKSTLKQEGGDGSTY
                     TEGEKELMIWYSYFFLGRGKPTTHLSLFSNNTDIDFESFPYCLKEFVNSIIEKMIDDS
                     GGGRK"
     gene            50543..52408
                     /locus_tag="KRO40_000668"
     CDS             50543..52408
                     /locus_tag="KRO40_000668"
                     /inference="COORDINATES: protein
                     motif:HMM:NF024642.1,HMM:NF024754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBH2091507.1"
                     /translation="MKRNWVSKEDWSPAAGFRLEVEAMNTVINDKNTLVVAGPGAGKT
                     ELLAQRACFLLETNTCRYPKKILAISFKKDAAENLKERLELRCGKELASRFESKTYDA
                     FAKEIVDRFRNSLDEAYRPLNNYNIAENRDVRRAFEIAGLNFRGNQTEFNKVYGNKLS
                     INKLPLHTDFVDKIFIDAWNVLLKGNKDTNFVSSLTFGMISRLAEYLIRTNRYIKKAI
                     EMTYSHVFLDEFQDTKSIQYDLVKACFFKTETIITAVGDGKQRIMLWAGARKSIFEDF
                     QNDFLSQKRTLIMNHRSAPRLVEIQKAMYNSLNEEAIDLKTNEKWNYEDGEVYLRLFE
                     DYIKEADILSEEIVELVETGIEINEICILVKQSVDIYSKEIINKLSERNIKARNEAMY
                     QEILKEDIIKTLVSLFRLSLSDRNPDDWDYIYDILGELYGIDEGYNPKILNDFITKVE
                     LMINDLKVNLNITDEKQFSDLVDSKVEYISYEKFASKFQKYKSKDYFDDLVDKFKKLV
                     WIEYNETKDWIKAIDNFEGKNSIPIMTIHKSKGLEYDTIFFVGLEDSAFWNFKNQPDE
                     DRCAFFVALSRAKRRIDFTFSLDRPAGFSNSQKHYCINEFYELFDNTEIVKKIEY"
     gene            52532..53346
                     /locus_tag="KRO40_000669"
                     /pseudo
     CDS             52532..53346
                     /locus_tag="KRO40_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728762.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            53371..53859
                     /locus_tag="KRO40_000670"
     CDS             53371..53859
                     /locus_tag="KRO40_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HBH2091508.1"
                     /translation="MYEKDYKQYIKLDIPIDEAKIKNRFEIRLKNERAYHAAVDLLAN
                     RDEEKTAFSIINRYIRFVDKDDEKIRSEWKTNDQWSYFIGEGRAKLKLTTNPEPYNIQ
                     KTLNWLSRQVAPTLKTIKRLDSLNNSTLIEGLIRYARLTDKHKKIIEQNSVNVEDIIY
                     DE"
     gene            53972..54133
                     /locus_tag="KRO40_000671"
     CDS             53972..54133
                     /locus_tag="KRO40_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091509.1"
                     /translation="MAIAIIGVYLGFKREFSKLIGFLVVALIAVGLVFNTAGVKDILL
                     ELFNKIIGV"
     gene            54373..54600
                     /locus_tag="KRO40_000672"
     CDS             54373..54600
                     /locus_tag="KRO40_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091510.1"
                     /translation="MDIVKVFANNVRKYRNKKGLSQEAFAEKAGLHRTYICAIERKKR
                     SIALDNVQKIADALEIETYLLFIEGEEKECL"
     gene            54597..57536
                     /locus_tag="KRO40_000673"
     CDS             54597..57536
                     /locus_tag="KRO40_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HBH2091511.1"
                     /translation="MKKLPIEKLIENLGFSGSKNLVNIDMLTKLDISKHDVKTLKVIN
                     PYAIYLVNSKPFILFIESSFEEKKLQQISKLIWNAQIPIAFICDSNSVKIFNGKALDL
                     KSYLIEEIYNQSIEDFSEESEFSYLKISDPLFWDQYTKQYTKTHLNDYLLDNITSLTN
                     KLKKKYKVKFATKLVLRLIFIRYLIDRGVDIAYKNFNHDIKASQKELLKITKNKVELY
                     ELFKYLKEKFNGNLFELNDEINNTCLTDEVFILLSDFLSGKISIDNGQMSLFSMYDFN
                     IIPVELISNIYEILLGKEIRNKDNAFYTPNYLAEYILDKTTLEFLKNNRQYKILDPSC
                     GSGVFLVNSFRRIIDMNLGDKLFCEDDKLLKELLLSNIYGIDINEDAIDVTIFSLYLT
                     ILDYKDPKILSEFKLPNLKGCNLIASDFFDDNKLESLKKINFDFIIGNPPWGSVSDGL
                     HLDYCNKNGYNDMQQNKEISRSFIFRAKDFSSRNTVCSFVVHSKILYTQKKPSKKFRE
                     FLLKKSQIFSVVEMSSVRKLVFKNADAPAAVISFKYNESEENLNNRIIYTSLKPNVFF
                     KLFNIIVIEKYDVKYISQKLLLENDWAWKTIVYGFSKDIDIIMNIKKKYQTVNEIILK
                     NSFVHGTGIQINGNESHDATHLKGKWYVDSKKGIDSFYVDINKGKELTQDKMRRPKAN
                     QQEIFIPPYVLLKKGVDTKTYRYRAAFSNDAFVYSDAVTGICGKKDNLTTLYCLTGML
                     NSSFYSYLNIMLGTSIGIEREQGFSTEIFTYPAIESDEIANLVVKIQEATKLEKTTMF
                     LNEKNSCKYIKQLDKLILKSFNLNDDKFIDYAINIQIPELTNSKSTNIYRKITKEDLI
                     NYSECFKEQFSSIYRRVGKSISISVYPKILNRFTVFELEVTDEKTDREIMVKAEADNN
                     MELFTKIIRYDYNDVFHQIRDIIHFGENSFYIIKPNCYKYWHPAIAEMDLADVLDQIL
                     SDTGGEE"
     gene            57536..58210
                     /locus_tag="KRO40_000674"
     CDS             57536..58210
                     /locus_tag="KRO40_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091512.1"
                     /translation="MGGFKNSSLNFYLKQGLYEIIIDGLIDCCLLMSKSCIEQSRKIL
                     NHEEKIRTHLVENYLENDIERRKTSLSKQHLRFEVEAQENYDNKNESYEGRVDIKVIS
                     KDTLADRRAYYIIECKRIDGKETLNKKYITEGVQRFITEKYSSHYGKNIMLGFIVKDI
                     NIQSNIQKINSLNQNILYTYIDTDMLTVRSDSENNYAVCESKYKVKSKLLLLNHIFYN
                     FSSIIR"
     gene            58371..58787
                     /locus_tag="KRO40_000675"
                     /pseudo
     CDS             58371..58787
                     /locus_tag="KRO40_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003455547.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
     gene            58747..61194
                     /locus_tag="KRO40_000676"
                     /pseudo
     CDS             58747..61194
                     /locus_tag="KRO40_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005423199.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            61334..61756
                     /locus_tag="KRO40_000677"
     CDS             61334..61756
                     /locus_tag="KRO40_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091513.1"
                     /translation="MRLEDIIDKESYEEKYDDLTVEIKKLSKEKKTLKASLINEKSIK
                     ARLREFRKILERNELLEKFDRYVFASIVDKVIVGVINEDGIVDPYKITFVYKTSFDDK
                     QDGHKFINKSPLETYSKDNNDNKKKCSYTNNETLRDCS"
     gene            62294..63328
                     /locus_tag="KRO40_000678"
     CDS             62294..63328
                     /locus_tag="KRO40_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YHYH domain-containing protein"
                     /protein_id="HBH2091514.1"
                     /translation="MFKKKLIAVAMSITMISVGSFSYAHSGRTDSSGGHRDNKNKSGL
                     GSYHYHCGGYPAHLHNNGGCPYTGGGSSSGTTTSVNNEEKQKRSVGEKGYNQGYEDGY
                     KGNYSSSNYSGDYSDTYESKYSEGYEKGKAKLEEEEKVAKETGYNLGLTGAKSNNTYE
                     KEVLKNAYDTGYSTGYNEYKTKKIEEYKAKGIEDSNKDKEKMTFEENIDSEFIDAYNN
                     AYDERQEQLKNDYTTQGFESAIKGERFDTSTIGNVKYANWFKEGYDNGKVKLPKAKES
                     VYNQGYNEEDFSIPDEMKSIETKLKGVYDEGLEKREEEKSRNATYGVGAGTAAVVAGV
                     VYKKKKRKKI"
     gene            63415..63618
                     /locus_tag="KRO40_000679"
     CDS             63415..63618
                     /locus_tag="KRO40_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4236 domain-containing protein"
                     /protein_id="HBH2091515.1"
                     /translation="MGFNFRKSINLGGGLKLNLGKKSVGISAGVKGARVSVNSKGRKS
                     ATLSIPGTGISYTKTSTKKRKPK"
     gene            63789..64949
                     /locus_tag="KRO40_000680"
     CDS             63789..64949
                     /locus_tag="KRO40_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp27"
                     /protein_id="HBH2091516.1"
                     /translation="MKLSKILLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGL
                     IADKQNYDIAILINSENGLSDGLSASGLSGAKNAPILLTKKDTIPSETLKRLEKVKEV
                     YLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAF
                     KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSMSDKLINETKATR
                     IGGVDRYDTNKQIINKFYNGSKEFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSI
                     LKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNTNKPSNEPSSNNPGL
                     TDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK"
     gene            65208..65348
                     /locus_tag="KRO40_000681"
     CDS             65208..65348
                     /locus_tag="KRO40_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091517.1"
                     /translation="MENLMMSIITGVIASYIYDKLKSHSERPTKSGWELNIKFQKSKS
                     SK"
BASE COUNT        25291 a         7501 c        11141 g        21789 t
ORIGIN      
        1 tgaaaagcat aattattaca tattgactta aaaataactt atagagatta gaataatttt
       61 agtttatata ttttttaaaa ctatacagtt gttataaaaa gaaaaattgc atacaagtca
      121 aaaataagtg ttattttata aaaatacgac aaaaatttta tttactactt atacaaataa
      181 catgcaaata acatataaaa tttaataagt aaaaaaaatg aaagatataa attatcattt
      241 tagtatttta tttagtcgaa gtaaattatt caaatgaaat atatctcatt tagataaaaa
      301 attttagtaa aagtaaaaaa aataatatat ttgttaaaaa ataaattgac aaaatattca
      361 gaaaaaaact tcttgaccta agagagtaaa ataaataaaa tctaaggtat agagatgaaa
      421 tctataaaat tattttaagt ataagttaaa aatatagatg atgcatttaa gatttataaa
      481 aattagagat gcataattat tttagggagg tttttagtat ggagaaaaaa gaaaaggtag
      541 tagaaaaatc aaatgttgaa gtatgtagtc ctgaaattgt caacagtgtt gaaacattaa
      601 gaatgagatt agaagaaatt agattggcac aaaaagaatt tgcaacattt acgcaagaac
      661 aggtagataa gattttctta gctgcttcaa ctgcagctaa tcaacaaaga atacctctag
      721 caaaaatggc agtggaagag actggtatgg gtattgttga agataaggtt ataaaaaacc
      781 attttgcctc agaatatatc tataatgctt ataaagatac taaaacttgt ggtgtcatag
      841 aaaaagatga agcatttggt tttacaagaa ttgctgagcc agtaggtgtt ttatcagcag
      901 ttataccaac aactaatcct acatcaactg caatattcaa atccctaata gcactaaaaa
      961 ctagaaatgg tataattttc tctcctcatc caagagctaa aaactgtact atagaagcag
     1021 ctagagttgt acatgatgca gcagttaagg caggagcacc aaaaggactt ataggttggg
     1081 tagatgttcc ttcgattgaa ttaactaatg ttgtcatggc agaggcagac cttatattag
     1141 ctactggtgg acctggaatg gttaaatctg catactcttc aggtaaacca gctgtcggag
     1201 ttgggcctgg aaatgtacct gcaataatag atgagagtgc agatataaaa atggctgtaa
     1261 gttcaatctt agtatcaaaa tcattcgata atggtatgat atgtgcttcc gagcaagctg
     1321 taatagtacc agaaaaaata tatgaagaag ttaaaaaaga atttaaatat cgtggagcac
     1381 atttcctaaa taaagaagaa actgaaaaag taggaaaagt agtaataatt gatggttcat
     1441 taaatgccag aatagttgga caaccagcac atgtaatagc caaaatggcg gatgtagaag
     1501 ttccaaaaac agctagaata ataattggtg aagtagaatc tgttgaatta aatgaacctt
     1561 ttgcacatga aaaactttct cctgtacttg caatgtacaa gtctaaaagt tttgaagatg
     1621 cagttgctaa agcagaaaaa ttagttgcag atggaggcta tggtcataca tcttcattat
     1681 atgcagactc tataaatcat ccagagagag tagaaaagtt tgtaaatgct atgaagactt
     1741 gtagagtatt agttaatact ccatcatcac aaggtggtat aggtgattta tataacttta
     1801 aattggcacc gtctcttact cttggttgtg gttcttgggg tggaaactca gtatctgaaa
     1861 acgttggagt aaaacatttg cttaatatca agacagtagc tgaaaggaga gagaatatgc
     1921 tttggttcag agcaccagaa aaggtttatt tcaaaaaagg atgtttaggt gtagcagcaa
     1981 gagaatttaa ggatgttatg gataaaaaga aagcatttat agtaacagat tctttcctat
     2041 ataataatgg atatactaag aaattaactg atttattaga tgagatggga attaagcata
     2101 ctacattctt tgatgtagct ccagacccaa cattagcttg tgcaagagaa ggagctaaag
     2161 ctatggctga tttccaacca gatttaataa tagctgtagg tggaggaagt gcaatggatg
     2221 ctggtaagat aatgtgggta atgtatgagc atccagaagt agatttccaa gacttagcta
     2281 tgagatttat ggatataaga aaaagagtat atgtatttcc taagatgggt gaaaaagcgt
     2341 attttgctgc tatcccaact tcagcaggaa ctggttcaga agtaactcca tttgcagtta
     2401 taactgacca agattcaggt gtaaagtacc cattagcaga ttatgaatta atgccaaaca
     2461 tggctataat tgatgctgat atgatgatgg agatgccacc aagattaaca gcagcatcag
     2521 gtgttgatgc tttaacacat gcattagaag catatgtatc tatgttaaga actgaaccag
     2581 ctgacggtct agcactacaa gcaggtaaaa taatatttga atatttacct cgtgcatata
     2641 aaaatggaaa gaatgataaa gaagcaagag aaaaaatggc aatggcatct actatggcag
     2701 gaatgtcttt tgcaaatgcc ttcttaggaa tatgtcactc tttagcacat aaattaggtg
     2761 cattccacca tgttcaacac ggtgttgcaa atgcattatt aataaatgaa gtaatcaagt
     2821 tcaattgtgc agaagctcca aataagatgg gtgcattctc acaatacaga tatcctgatt
     2881 gcatacaaag atatgctgaa tttgcttctt ttgcaggtat taaaggaagt acagaccaag
     2941 aaaaagtaga taatcttata aaagcaatag atgaactaaa ggcaaaagta ggtcttccta
     3001 agactataaa agaggctgga gtagaagaat ctaaattctt agaaagattg gatgctatgg
     3061 ttgaacaagc ttttgatgac caatgtacag gtgctaatcc tagataccca ttgatgagtg
     3121 aattaaaaga gatatatcta aaagtttatt atggtaaata atatctattg tgcaacatag
     3181 gttctattgg gtttgtatat aaattattag atttgaatat aaatagagtt ttattagaga
     3241 cacgtagaag taactataaa taatagatta taatttaaat tctaaatgga aatgataaaa
     3301 agtcagtaat ttaatggtaa tttcgaatat gtgtatttaa tcaattaact ttaaaattag
     3361 tcggaaaatt tttttattac atataatttt aaagcataat atataaaaaa ctttatgaaa
     3421 aaattataaa aatattcaga aaattctatt gactaattta tttatcatga tataataagt
     3481 ttagaaaaga aaaaaattgg ggcctattaa ggccccctta ctattttttg atagatttat
     3541 ttaaaattac tttctcattt tgatttttta tatttattat agagtcagta taatccactt
     3601 caaagttggc aaaagcagag aataaatcta tatctcttaa caaatgaatt gtcatacatt
     3661 gattgttctt atttagcctt agaatcaatg ctcttacaaa tggaaattgt attctagaat
     3721 taaataagtt agaaccatca gtatctatat ctaagctacg ataattaata tctataaata
     3781 tatctacatc ttcattttct tctcttatta ttctgtagtc aaaatccaag tttaaattta
     3841 aattacctaa aatcaataac atttaaatcc tcttttctat aaatagtttt agagtgttaa
     3901 tttaagctct ccatctatta tagatataat tctatctgct tttctagcaa tattttcatt
     3961 atgtgttatt attataagtg tttggttata tttttttata gaacttttta gtaaatccat
     4021 gacttcttct gtagttttac tgtccaaatt tcctgttggt tcatctgcta ggattatact
     4081 tggttttgca gataaagcac gtgcaatagc aactctttgc tgttgaccac cagataattg
     4141 gttgggaaga tgatttttcc tttcattaag acccaataaa tttataaggt catcaatata
     4201 ttctttatct atttttttat tgtctaactt tagtggtaat tctatatttt cctttacatt
     4261 taatacagga attaagttat actgttgaaa gacaaatcct accttttgtc ttctatatct
     4321 tgctaattct ttatctgaaa gacaacatat atctttacca tctaccttta tagtaccatt
     4381 acttggtctt tcaagaccac ctactaaatg tagaaatgta cttttcccac ttccacttgg
     4441 tccaattata gcaacaaatt cgcctttatt tatttttaaa tttgcattct ttagtgcatg
     4501 tacagatgtt tccttttttc cataaatctt acctaagtta atagtttcca atataggcat
     4561 aattattcct cctattctgt aatgtttata gcttcaacta tactaatttt atttatcttt
     4621 cttgatggaa tatatgtagc tagaatacct acaattatat ttgctacaac aactagtata
     4681 tatattttgt aatctattga aaatcccaat ccatatgata caaagccctg catataatac
     4741 attttaaatt gtattataat tcctgacacg atagtaatta tacttgagag tacaccatat
     4801 aatattcctt cataaagtat catattttta aagcctctct cagagatacc aatagctctt
     4861 aacattccaa attcactagt tcttgaagtt aagttataac ttatgttgtt tattatgtta
     4921 agtacactga ttatgaacat tattgctact ataccataac tataaatcat agttctagat
     4981 gtcatcttat cagaattttc tttttctacc atcatatcta ctgttgtagt tccaggaact
     5041 tcacttccaa ttttacctaa aaggttattt atttttttct tgtttgcatt ttcattaagg
     5101 tctgcataaa ctaagttata cttatctaca ccagttaatt tttttaggta ttcgctactc
     5161 gttattacat ctacaccatc atctccagag tacataccat tatctgcaaa aggataactt
     5221 ataatagctc caactttaaa ttcatattct aagtattcat aattatcttt tagactttca
     5281 taaagacctg tatccatccc accctttgga tatttgactt ttatagtatc acctactttt
     5341 atatctacag ctggtgttcc ttcaccagga gtaaaagtct ttgtgtattt ctgtgtttta
     5401 gaaatttctg gtacatatac aatagctaaa ttttcttttt tcattttttt caagtttata
     5461 tttccactta ctaagtattt ttctaatgac tttatcatct catcattata accttttagc
     5521 ttttgcttta gtgtatattt gccagtagtc ttatttttta tgaacagagg atttagctta
     5581 taataaggag ttgaatttat agcttcgtag taatctaatc tatttatttt atttacctct
     5641 attcttgtgt ttaagatact agcagttttg actttgtcaa ttccatctat attttttatt
     5701 ttatctatct gattatcatt aaaccctttt atatctttaa aagaagtatt gttaccaatt
     5761 tcattgagat aaacatttga tagaataaaa tctgcattca tatatgtttg ttcttgagta
     5821 gatttgtttt gcacatctaa aaaagaatat ttataattgt cttttatgac gattatacct
     5881 cctatactca tagataatac aattataatg aacccctttt tatttctaaa gatgtttttc
     5941 gcagatatag attttgttac tgacatattt aaagttaatt ttgatattaa ataattaact
     6001 ttggttacat ttttatcagc tccaaaagtt tttctgatag catcaatagg agaaattctt
     6061 cttattttta agtatgtaaa gaaacttata attagtatta ttagtattgt acatgcaatt
     6121 gataagagaa ttattttatc tggaataaca aaaggtgtaa catttatatt tccttcaaat
     6181 tgaatatttc ctacagacct attaaatatt tgtgcacctc ccatacctat acatatacct
     6241 ataggcattg ctattagagc aagtatgaaa agttcataaa gcataagttt gaaaatccta
     6301 aagttggtgg aaccaatagc tcttaagacg ccatattcct gtactctttg gtatattgat
     6361 ataacataga tactatatat tacaatacca gcaaatagac tcatagcaat tgcaacgtat
     6421 ttacttgaat tatctaaagt accgtttttc atagtagatt ctataagcat tgagtttctt
     6481 cctatacttt tctcatctaa catagcattt tttattatat tgtctatgtt tgtatttata
     6541 tcactgcctt cattaaattc aatataagtt gtaaaatcat tcagttctga ttcattgaga
     6601 ttagaaaaaa tttcacattg tccctttttt ttctctataa atctatcttc aaggattcca
     6661 acaactttaa aagtttctgg attttctttt tgatataatt taaaagtaag gttttgattt
     6721 atctctggtt ttaagcccat actatttaaa atccatttct cgactaccac ctcattgcta
     6781 gcttttggaa atcgaccttt tataagttta gaatgactag tcaaataatt tttatttgta
     6841 tatagtatgt ttataggtaa tttttcatta acatctgtag acgcatagta agatgttata
     6901 cccagatttt taatatcttt gctagatttt atggacttta attgattttt ctttatattt
     6961 ttaaagtata catggtcagt tccaagctct cttttcaatc tatctacatc tgcttgctga
     7021 gcacttcttg agagagtacc aataccaaca acgagtgatg tagcaagaat tatactcaca
     7081 acaattgcta aagacctagc tttataactt tttatatacc ttagtactat tttcaaatta
     7141 tctttcatat ttaccacttc ctttcttaac taaatcaatt atatatttat ctaaaatata
     7201 tagcaaagta agtattttca aattttaagt agttaattgt acaaattcat ctgtattttt
     7261 acaagtttaa ttaatatata tgtaaatttt aactttttac ataatttttt taaaatgata
     7321 taatccctat ataaattgta gaggggaggg gaatcatgga taacaatttt gtatttccta
     7381 tagtaatact aactttgttt atatttagca atcttataat gaataagtat aaattttaca
     7441 aagaattaga catattaaaa agaggcatat taacattttt tatatcgtgt tttgcattga
     7501 ttttatttat ggagggcact aaatatatac aattaaggtt aggatatagt tttttacttg
     7561 aaggagtatt aaatattata ctttttttgg ttttaattat tttaagtttt tatacaggct
     7621 ttaaagttat aagattgata aataataata atgaacagga atataaatta caaaaactag
     7681 atagtaaaat aaatcataag gataatataa ttatcaaatt aagaagtcaa aaacatgact
     7741 atttgaaaca tttgcaagta gtgtattctc tattaaatac tgggctagat gaagatgcca
     7801 aagaatatat aatgaatata tcaaatagct ttaaatcaaa aaattcaagg tatggaaaag
     7861 tatcttattt agatgctata gcttcattaa aatacgagga atgtcttgaa aaggatatat
     7921 cttttgatgt ctacattcaa gattttatgg ataatttaga gattgaacct aatgatatga
     7981 gttcagtact attaaacata atagataatg caatagagtc tttgtctact ataaaaaaag
     8041 aaaagaagta tataagatta catgcatatg aagatgaatt tcagtatatt atagctataa
     8101 aaaataatgg tcctaaaata cataatgttg aaagtatatt ttggaatgga tttagtacta
     8161 aagaaggaca agatagggga tatgggctac atttagttaa aaatatatta gataagtatg
     8221 attatagtat acttgtaaat agtgatgatt ttttaactga atttgtaatc ttaatcccaa
     8281 aatattatta gttaggagga gaaaagtcta tgataaaagt tttgatttgt gatgatgata
     8341 agattgtaag agatgatata gcaaatatag ctaaagagtc tggatatgta gattatgtta
     8401 aaaaagttaa ggatggtata gaggcaattg aatttataaa aaatgagaaa atagatttat
     8461 tgattattga cattgatatg ccatataaaa atgggattga ttctgctgaa gaaattcttt
     8521 ctatagataa ggatatacat atagtatttg tgacgggttt cgctgattat agtcttgaaa
     8581 gctttaaagt gcatcctata gattttgtag ttaaaccatt taaaaaagaa aaaatacttg
     8641 attcaattaa catagcaata gaccatatta actcccataa gattgctaat aataatttta
     8701 tagaagacac cctttttgta tataaaataa ggaagcagat acatatgatt aattttgatg
     8761 atatagttat gtttgagaaa aattcaagag caattaatct acacactaaa gatgaagata
     8821 taataaagtt ttatgagaac tttgatgatt taaaaaaacg cctacctcct aatttcttta
     8881 tgacccatag acaatacata gtaaatctaa gatttataca taaggttata cctataaata
     8941 aatcttcatt agagataagg tttataaatt ttcaagaaaa tgccatatta aacaaatctc
     9001 tagaaaaaga ttttttatat agattttata gggttaaaag attctagtga agatagaaga
     9061 aaaatacttt ttgtgtgata taataagtac cgtaaagata atgtataaga gaagtttata
     9121 taaaaattat ttgtaattat gatttaatct atataaatta cagtatagta tatattggac
     9181 tttctaattt ttttaagaaa gtccaatata ttttagagat agtttttata cttataaatt
     9241 acttaagata ctagggtctt taatcttact atcttcagca agtaatagta tcttagacat
     9301 aatctcagca gttttagggt cttcatcagc gaatggaagg aatatcttac ctctactttg
     9361 agaatgtata ggaagtatat tcaaagcacc catccctttt ttatgtacaa taccagaacc
     9421 catatgcaca gaatactcac ctaaattacc tgctataaga gcatgagagc cttcaaaatt
     9481 gacattgtta atttttaata ataataaaag ttctttagca attgctatac gcatctctac
     9541 agtagaatgg ctagtttcag ggtcaacacc accagcatga gcgacactta caacaaggtc
     9601 tatatcacgc ataacttctg agaatagaat tggaggtata gaagctaatt ctaaactttt
     9661 ataagttttt ctatcaaaaa attctactgt ttcaatagta ggaggctcta tatctgctgg
     9721 tgaaaaccaa tctgcaagtg caaacatctt tgccactata ttttctttat aaaatacttt
     9781 ctgtaatccc tcttcataat cgacagtcca aagctgattt ctaagaagtg ctacagtttt
     9841 ctttggctga atttggtgac cagcatatct gcgagatata gttttttcag ataattcatc
     9901 actgtttatt ctataatact cacggaatac ttgcttaaat ggttgaacaa tttgcttact
     9961 aaataaatca tgttggaact cactccactt accagattca aacaaatgaa ctggatgtgc
    10021 aagttttaat ttattttttg ccgtcaactt ataagtttca ccttctatat tgcaaataaa
    10081 gaacttagac ttatcattat aaacatatcc aatattatca tcacataccc atactagatt
    10141 tttaatcaaa gggcagataa ctggattttt atagatattg gcaatttctt taactgtaaa
    10201 tactatttca tttttcatag cttgttctaa actctgtttt gcacgagaat actgactctt
    10261 taaatctttt tggacagatt taagttcaag tacatatgga tgtttagcaa tagcttttgg
    10321 tatactcttt aaagacttgt tgcctttttg aactttagta gatgcttttc cgttttcatc
    10381 aacatctatc caaattgaag taccatcaat atcttttggt ttaaatagat gagcaacttc
    10441 atttagtttt tcagtctcaa gagcccacat catacgattt acatctccaa atccagcact
    10501 tctagctaga ttttctagcg ctatagtaca agcttttgat tcactttcac gacgttgtgc
    10561 accaaattgc ttgctttctt tagcaaactt ttgaataaat tcataacgga aagttgcttc
    10621 ttttaggtct ccttttttca taggaagtaa agagaaactt ctcaatttat cttgatttct
    10681 atttgtttca atttctttca tcaacatgtc tttatcaagc ttaccaagtg tagcatcagc
    10741 atagagttgt gcacgtctat gagagttacc accactagtt atatatttag ctgacttgta
    10801 aagtatattg aatctttctt ccccaatagt tttatatgaa tctaaaaacc aatctacatc
    10861 aaatgcacca tcaatgaaac tacgtggtga aataggggag aatagagcaa cctctgattc
    10921 tttttgtgca gagaagcctt catttatatg tgcatggaag taccaaattg tacttttcag
    10981 acccttccag tttaaatatt tttcaattat gtttacccat tgaggggcat acatagcaga
    11041 ttctatcaat cttaactcag taatgtcggt atttttaagt aaacttttta atttttttga
    11101 atcatcttct ttagtaggat agcaattttt aagtagagaa cttaaaacat ctttttttga
    11161 ataattgcta ccatatgaat atcctctctg gaaagtttct ttaccaagag cgaccaaaat
    11221 atttacaaaa taatttatac cttcaaagta ttgtatatta ttagctagat tagacacttc
    11281 tgttggcata tcacctctac gtgattcaat ttctataatt cggtttgtaa cagtttttaa
    11341 attatcttta agccaagggt acttttctaa tgtgtcgcca gcccatctag gatttgtcaa
    11401 tgttcttatt atatttgatg cgttgtatcc acttatcatt tctctattaa cttgctcttc
    11461 agtcattaat cctaattcat gtgcacgagc aaacacattt atgctagtat agaaaggaaa
    11521 cttatattct agcaactgat aatttgaaaa cgtagtgtag aaaaacttag taaaagaaat
    11581 atcatcataa ataaacgaat gtgctttatc aagccaatag tttaaaatag gggcatttaa
    11641 agcagggcag tattcatttt gtctgtaata gtttttagta aattcaactc tttgtttttt
    11701 acattgttct atagtcaata agtttctaag tttatagtat atttctaaac aatagttaaa
    11761 tatttcttta tggtcaaact catttagtaa aactcttaaa agttttcttg taagtccatt
    11821 aaatttaagt ttttcaagtt ttgtatatat tttattttgt tttttagagt caaggacatt
    11881 tgaatatata gatgaaaacc aacttttttc tgtttcatta tatccacatg tacttatact
    11941 ataaaataag atatcaagta ttaatttgta atctaagtca agttttttac tagtttctct
    12001 ccaaagctct gctaatggat aattatcaag agtatcatta gaaactttat atttaatagg
    12061 agtcaagtta taagtagaat aacctaaaag tactttgtct acattacctg accatctttc
    12121 aacttcatat tcataatctg cattttcagt aataagttca tcaaattttt cataaacttt
    12181 tattatttta tttatatccg tatcgagaat tttttttgct tctttttttg ttgctacaga
    12241 aacagaatcc tcacgagtag ataaacttat atttgagata attttattaa gctttgatga
    12301 gctattagaa tcatctttaa aatcaaattg ttctggaatt tgaactttgt tttcagggtt
    12361 atatattcca aaaccatttt ctttgcagta atcatttttt gctttaccta acaaattatc
    12421 aattagtatt tgaacttgag atgtattctt tttagattta tcaatatcct ctataagtaa
    12481 aataagctta ttatatagtt cttgtctagc agtattgtct tttaataagt ttacaatttc
    12541 aagacctcca aggcattttt gagaatttga agattttatc agtgaagaag caatattttc
    12601 caaatttgaa tcatcttgtt caagtaaaat ttttattact gtttgtctaa tagagcttgt
    12661 ctttaaagac aatagattgg ttatcttatc taattctaca tctgttagct caagctttct
    12721 aagtagactc aataccgttt ctctattgga aacactctta tcacttaaac attccaataa
    12781 aaattcacgt tgtctatctg tctttggttc atttacaaaa ttgactataa gtgaagctct
    12841 taaatctgaa ctcataagat gacaattttc cataagcaca tctataaatt gagcattcat
    12901 atcgtatgct gttaaagtca tcatacattt aagtatttca tgagaagaaa tttcaatcca
    12961 agtccatgga aatacacttc ctgaaaatga ttttgtcttt gaatttaaaa tttctaaagt
    13021 atgttttaaa ctttcaaatt gttcttttct agcatcaaag tctttgtcaa taggagtgtt
    13081 tgacaagtca aaattagttt ctctgttttg ccaactatag tagtagccaa cagaaccttc
    13141 tacatagaaa tttgtaatta cccatgctag tatctctaaa tcatcaccct taatgttttt
    13201 agatgctata gaatgtttaa aatatgtact ttctgtatgc gataaaaagt aaagagctac
    13261 aagtttttta tatttttcct gacaagaaag taagttttca ataagagagt aagagtcata
    13321 tatgttgtaa gttgcagtag cccataaggc aaaataaatt tcaagattat cattgctatt
    13381 aattgattct atacggaact tttcatcagt caatgattta tatgaaagtt ctaaacattt
    13441 acgtattatt ccaggttttt ggtctgaaaa accaagtcct gtccatgtat ccaaggctct
    13501 tataacagaa ctaaatcgct ctaaattgtt gtccaaaata gtttttaaca tgtatattga
    13561 tgcagaaatt gtaccctcat ctaaactctc tacaatttgc tgtctaagtc cttcttgttg
    13621 tttggctgcc aaaagaagtt tagaaagcat ttcatagcat ttatcactat gactcttcat
    13681 gataccaatt atcatttgtc ttgtaagtag agcagtttga ttttctccaa atattacttc
    13741 ttctaaagca cttattactt tttgatttcc tttgtctatt tctagtgcta ttttatcact
    13801 cattatagag tcatagtaca agaccttatt tggaagagta agataatcta taactgaaaa
    13861 atcataataa attaaatcaa catagtttga aataaacctt ataatacctc taaaataatc
    13921 cacaagttta tttgagcgat accctttacg ataatatcct cctgaatatg tataatccat
    13981 ctttctttta attaattggc aaagttcttc tacttgttca gaagtaaata ttaattctaa
    14041 tgcatttttt aaaggtccag aaaggagctc gtccatattt ttaatttcgt agtagtggca
    14101 attgtagtat ttctttatca tatttaagaa tttgtcttca ggttctctat aatagtatga
    14161 actattttct atgcagtccc aaagagactt tgctaagtcg tagtactgtt ttgaagaaga
    14221 tttagtaaaa ttatttttaa aattttcaat tattttagga tttttttcta ctctagtacg
    14281 ttctaacatt tatgtacctc caaattattt attttaaaac attcttccag caagcaaggt
    14341 aagtcttata aaagtaaata tatctccact tttcagattt atagaggaat cgagtttttc
    14401 aataacatcc tcatttataa gcactttgta gattccatct tcaaatgcct gtaacgctac
    14461 ctctattgcc ttttctacag attgtttatt ctcattgtaa atagagccaa atccaacttt
    14521 tccaatatca gcttgagatt caatttcttc attagttaag aagtttatta ttgatttttc
    14581 tgggattttc tcattatatt caagaacatt tttagataca atttcagaga tagcttcttt
    14641 taggcaattg atgttgtcag atacatcaaa aggggtaagt tctagcatag gtttgcgttt
    14701 gccaacagcc ttaactctaa aataaatttg cataaaatca cctcgcaaaa tattaattat
    14761 gtatttagaa atttaaaaat ttatctattt gttatattat atcattttgt gaattattaa
    14821 tgtgaattat ggaattattt tacaaaaaat agaaaaaaag ctatcttaaa gtctaaaaaa
    14881 gcaataaaag ataactttta actataatta tatagaatta taactgtaca tttattaaat
    14941 tttaatttta gaattatttt tgataactat ctttttttat ttataaattt tgctcctaaa
    15001 tattttttga tatcttcttc aggagaaaag tcatcaataa gtatttcttt cccagtgtct
    15061 tcaaatacta caagaacttc acagtcacct tgtaagaaaa attttctaac tgtatcttct
    15121 ttaacttctc taacttttat tacattcttt ttttcttttt caaagtcttt tgtgtaataa
    15181 cttcccatca tattaattat ttttgtatat ctattcataa aatacctcca tatgcgatta
    15241 aatttaaaaa atatgttata ataattgttt gtattaactt aataattata acaaggagta
    15301 ataataatga ctagtataaa aaataaagat attttaaatt gtatagatta ttccattaaa
    15361 aataagctct ttgacaaact aaatgatgta tataagtcct tgccagtagg aaattgttct
    15421 ggatgtggaa attgttgtat ggagtcagta ggtataaatt taattgagtt cttgaatata
    15481 ttttgttatc ttgaagatag agttgattta aaaaaaagct gtataagtaa aatattagat
    15541 tattattttg aggagtatac aagaaagaac ccatgtccat ttaaagatac taataataga
    15601 tgtttaatat atgaagttag accattaaat tgtaggatgt ttggacattg gaaaaaagag
    15661 gattataata aaaatttaga taatgttatt gagaaaaata ataactatag agagttaatg
    15721 aaaaagcaat atggatttga aataaatgat gaagtagtaa attacaggat agattattgt
    15781 gatagattta ttccaaataa agattattta agtaaatcta agagattaag cttttttgat
    15841 gagcttatga tattagactc aaatatttat tcaagtggaa atatagatat agactttagg
    15901 gatagaggta tagttgaata ttttatagag tcattacttt atagaaattt agcatataat
    15961 gtgaaaataa ggatatctaa agaatacaaa ataagaaaaa gaactataga tagaataaaa
    16021 aggattgttc ttgtatagtt ttatattagt aagtaataaa ttgtatcata aatattgtca
    16081 aaatgaggtg aagaaggtga atcttacaaa agtaaaagga aatacctttt ttataaaagg
    16141 tggcacgaat acaggaatat atgtatttga agataacaca gcacttatga tagacccagg
    16201 gttatgtggt tcaagaccta ggagagtaaa taaagtatta gatgaaaata atatacaggt
    16261 tagatatatt ataaatactc atggtcatga tgaccactat ggagcttgta atcaatttaa
    16321 agaatattat aaagatgtgt gtataatgtc atctgaatac gataaattat atatagaaaa
    16381 tccagaattg ttttcaaagt atattgttgg gggaaagagc aatgtattta tggataatat
    16441 cttaaaaaat aaaatgttgg atgatataaa aatagataaa tctatagaag ctggaaaaat
    16501 tgaattaaac aatgaaatgt ttgatataat tgaatttcag ggtcatacac ctggtagtat
    16561 agctgttttg acgaaggata atgtgatttt tgttggcgat ttattgatag gagatgaaat
    16621 tctatcaaaa tacgatttct tgtttctata tgatatacaa gaacaaataa attcattaga
    16681 aaaattaaaa aatatagatt ttgagtactt agttttaggg catggcaagc aagttatatc
    16741 gaaagaagat tcttataaat taatagaaaa acatttgaat gctttaaaaa aatatttata
    16801 tcaaataaga gagttgcttg tagaaccgaa atctttagaa attttattaa aaaacattat
    16861 aaataacaat aatttaagca ataattataa agagtatcat ttttttaaat cttcgttagt
    16921 atctgtcata agttacttag ttgatttaga agaaataggg tatatattgg aaaatggaga
    16981 attgctttac tatacaaaaa caaaataaat tatgataaaa taaagaaggt cataaaaaac
    17041 aaataaaggg tgagcaatat ggaatacgaa aaatggaatg agatactagc accttatgaa
    17101 catgcagtag aggaattgaa aataaaattt aaaaatataa gaaaagaata tttagcaaaa
    17161 ggtgaatatt ctcccataga gtttgtcaca ggtagaacaa aaaaaatatc ttccataata
    17221 tctaagttaa aaaggataaa tgcaaaagat atagaaactg aaattgatga tattgctggt
    17281 ataagaataa tgtgccagtt tgttgaggat atatatgcta tagttgattt gataaaagta
    17341 agaaatgata tgactataat aggagaaaaa gattatatta caaattacaa agatagtggt
    17401 tatagaagct atcatgttat aataaaatac cctataaact ccattgcggg ttcaaaggaa
    17461 attatatgtg aaatacaaat aagaactctt gcaatgaatt tctgggctac aatagaacat
    17521 tcattaaaat ataaatatga ccattacata cctgagactc ttgctgaaag gcttagaaga
    17581 gcatctgatg ctgcctttct tttagaccaa gaaatgagtg aaataagaga ggacataatg
    17641 aaagctcagg ctatgtacca aatgaagtct atagctatta gagatacttt aaatagaata
    17701 caagagttat atgacttggg tgatacacat aaagctatgc agtaccaaag aaaacttgat
    17761 agaactgaaa cagataaaaa tataactgaa attttggaat taaaacaaga aatagatata
    17821 ttattagagc aatataagga tactaaggta gatgataaag tagttcagta aaaactactt
    17881 gtagaaaatt tgctaaatat taatggggct gcctcttaat ggaaaataat ttctaaaaag
    17941 agacagccta tttagtgtaa ttaagaaagg aatgatatta tgagtttgta tgctataggt
    18001 gatttacatt tttcaacatc agtcaataag ccaatgaata tctttggaag taattgggat
    18061 ggtcatgaaa agaaaattat agataattgg aaagaagttg ttaaggaaga agatatggtc
    18121 ttagtactag gagatacatc ttggggaatt aatttatccg aagctaaaaa agatttagat
    18181 ataataagca aacttccagg tcagaaaata cttataaagg gaaatcatga ttactggtgg
    18241 acaaccgtta caagtttaaa taagctatat gaagacatgc gttttattca gacaaatttt
    18301 tatgaatata aagattatgc aatttgtgga ggtaggggct ggatatgtcc taatgatgtt
    18361 aaatttgatg agactgatga aaaagtttat aaaagagaag aacatagact tagactatca
    18421 ttagaatctg ctcgtaaaag tggtcactca aaaataattg tgattactca ttatcctcct
    18481 acgaatgata aattggaaga atctttattt acaaagttat ttgaagaata taatgttgaa
    18541 aaggtgattt atggtcactt gcatggtaaa gaatctttta aaatgggatt gaaggggatt
    18601 cgaaatggag tagaatatac attagcatct tgtgactata cagaatttaa tttaataaaa
    18661 gttcacgatt aaaaaacata aattggtaaa tactataaga tacatgatta aaaataaata
    18721 tttgagggat ttcggttttg agaaaggaga cacgacttat gaggtggata ttagttttta
    18781 tatttttata tcttattcct ttagtagtga tattcagaaa ttacaagaat tttaagaggt
    18841 cttgtatcta cagtagtatt tatgtggtat tagctacaac aataatgata agtaatattt
    18901 atatgagtgg acttaataaa ataaaagagt ctatgtatta tcacaattat atttctgatg
    18961 agacatatga tgaaaagtat gtatcaaatt ttaaggaaaa agaaagtact gatttaaaac
    19021 aggataataa aaagaatgaa gaaatatcaa ataataaaaa tttaaacaac aaacaagata
    19081 gaaatataca aaataaagaa agtaatgaag aaggaagtaa tgatataaaa gaaaagaata
    19141 attctgatag taatgtttca gtgaataata aatcagaaaa acaagaagat aatacaaaag
    19201 aaaataataa atatacaagt aaagaaaaaa atagtgaaga tataaaaaaa atagatatgg
    19261 aaagtatagg aatttttaag aaagaaattt ataatataga aagagcagct ttagttccaa
    19321 tgagagaatg tataccttac actaaggata tagcaaaaaa tataactaaa ttatctagta
    19381 taaaaaaaga tgttacaaat gccagaaaca agtgtaaaga agttgtaaaa gaatatgaaa
    19441 atatgcagat tccagaactt tctaaggaga agtatacaga aacattgagt aatgctagag
    19501 atgacgtaaa gaaagcatat gagcttagag aaaaatctat ggaaagtgct ttgaaattaa
    19561 taaatactaa aagccctaaa tatataggga agataacaga atatcttgat ttatcagata
    19621 agcagataga aagttttaaa aatagattga acgatttaaa agaagaaata aataattcag
    19681 aaacaaataa tattaattaa taagatttaa agatataagt taaaagggag attatgatga
    19741 ataaacagag tataggaaaa ctaaatatgt tttttatggg gattactcaa agaaaccttg
    19801 ataataggga tttttttatt gagttagagg tgatttttaa atctggaaga aaagagttta
    19861 aaggaattgc aatagaggaa gataataaat ataaatttaa ttttaaagga aaatcagatt
    19921 tatatacgtt taatgagttg cttaagaata tttctaaaga ggcagaaaat tatgatggat
    19981 tagtatttaa atatgttgag cgaggaacta ttgttgtaat tgaaggagac aataagaagg
    20041 taaatgtaaa atatttagat aataaggaag aagtacctaa aatagatgaa tttacggcat
    20101 ctcaaataaa aaacagagat tattatgtaa aagtaggaca agcaaatgca cttttaaaag
    20161 aaattggagt acttacaaaa gatggtaaga taaaaaatga taaaataaga aaatacaatc
    20221 agatagacca ttttgttgaa ttgatagata gtattttaaa agaaataaag gataaagact
    20281 gtataactat cttggattgt gcttgtggaa aatcttactt aagctttgtc ttaaattttt
    20341 atataaaaga agtattgaag aaaaactgtt attttatagg aatagattat tcagatgtag
    20401 ttatagaagc atcaaaaaat atggctaaaa acttgggtta taaaaatatg tcatttataa
    20461 aagaggattt gactaattat acacctaata gggatgttga ccttgtaata agtctacatg
    20521 cttgtgatac agctacagat atggcaatag gtctaggaat tagagcaaaa tctgaagcta
    20581 tagtagtagt accatgttgt cataaggagt tattagggca atatagatat gaagctatgg
    20641 aaccaatatt aaaacatggt gtatttaaag ctagatttgc agatttaata actgatggtt
    20701 taagaacatt gttattggag ggcaatggat atgatacttc tgtagtagaa tacatatctc
    20761 cacttgatac accaaaaaat ttaatgataa gagcgataaa aactaaaacg aataatgaca
    20821 aagcattaaa agaatataaa gaactgaaat cacaatttgg agtggaacca accttagaaa
    20881 aacttatata ttagttaaaa atgtaaaatt tacgaaaagc ttgcttaaat atgcaagctt
    20941 tttggtatta tataggtata gtcatatcca gagttttgat ttataattaa agctgtgcta
    21001 taatatttga ttaatcaaat caataaatgt tacatggagg taaaaatgaa caaattgaat
    21061 atatgtattg atatagatgg aacaataaca agcccttatc attttcttcc atacctaaat
    21121 gatatcttta ataaaaatat aactgaagca gagtgtataa cacataattg ggaagaattg
    21181 tatggttcgg gaataagaga tgtgtatgcg gagtttaata ataagtatat acactcatat
    21241 gatgaagcaa agattgtaga gggtgctaca gaggtaatta gcacattatc taaaggacat
    21301 aatttatctt ttgtaacggc tagacatgag tgtttaactg atgtaactaa aaattggcta
    21361 tcgagacaag gattttcaga tatagatgtt tacttattag gaagtgatta taaagttgaa
    21421 aaggcaagag aactgagttg tgacatattt atagaagata atcctttaaa ctcagtgcaa
    21481 ctagctgatg atggtgttaa agtaatactt ctggatacta actataataa agatgttaaa
    21541 catcaaaata tagttagagt tagtaattgg atagatattg aaaagattat aaaacaaggt
    21601 atttaaagat ttgtagattg aaagggggag catatgatag atttaaaaat tgaaaataga
    21661 aaaggaaaaa tccatgtaaa gagcagtgaa ataaaagaca ttttagaatt acgtccagac
    21721 ttcgaatatg tacaagatat atcaaatact ataaatcaag aaaatatatt ggtatttgat
    21781 tgccagttga caggaaattc ttttgatatg gatgatttag atatagaaga aatattggaa
    21841 gagttaggtg aagaaataga tgagtcttat ttcagtgttt tatttgaaga tgtaagagcg
    21901 tatttaaaag atgctactga tgagatagaa gcagacttac aggataatta cttatttgat
    21961 aatttgagat gttattttga tatatacaat ataaatcaag aatttacaga ttttaagttt
    22021 gtatttttag tttcttttaa agatataaaa atttcttcat tagcaaacct agctaagatt
    22081 gtttctaaga gacagcttat aggtgcatct aagttttata gttaaaatga aatattatta
    22141 taataaaagc tagtaacctt gtaaaaatat aggttactag ttttttattt attcattttc
    22201 acaaaatttc agaaaactat ttacattcta aaaaaagtaa tgtatattaa acataatgta
    22261 cattataatg gataaaaagt ttctattaaa ttactaagtt tatttaataa tcaaaataat
    22321 ttatcttata ttagtatgta ttagggggta tttatgcaaa gtttaaatga aataattgct
    22381 gaaaatttaa aaaagataag gaaagaaaaa catcttagtt tagacaagat tgcacaactt
    22441 agtggtgtaa gtaagagtat gctatctcaa attgaaaagt gtgaggtaaa tcctactata
    22501 tctactttga agaaaataac taatgggcta aaaatttcat ttacatcatt gatggagagg
    22561 caggaaagtg acatagaatt gattcaaaaa agtgatatag accattttat tgaagataat
    22621 ggaaagtata taagttatcc aatatttcca tttgactcca aaagaagatt tgagatattt
    22681 atgattgaaa tagaagaagg tggaaattta gattcaaatg ctgaacttcc aggaacacaa
    22741 gagtttataa ctgtttttag tggcgaagta accattaaaa taaatggaga agattacatt
    22801 gtatctagtg gaaattctat aagatttaaa gctgatgtat cacatatata tagaaactca
    22861 ggcaaaggta tagctaaaat gagtatggta gtatattata tataaataat ttaatggaat
    22921 tagagtgata tttagatgat tttaggtatg aagatatatt atatttaagt tataggagtg
    22981 tgatttatgg atgaataata aaaaagcagt ttttttcttt tgcagtgatt taaagaaaga
    23041 cccagtagcc agtaatgtga taaaatgttg tgaagaaata atggatttaa atcaaactga
    23101 tattgttatt gatgataatt ttgtattaga gtttaaggat aaaaacaata acttatttca
    23161 ttttgtaaaa acaaaagatg taataagtca taattataaa tattatcttc caattttaaa
    23221 tagacatttt agagattatg attttgcagg agttgtaaat tggcatgagg gagaaaatgc
    23281 tccagaacat atcctaacag ctcatacaat tggagatgtt ccaacaggag aatttggaaa
    23341 ttcaaatcca agatacttta aaaatctaat caatgctatt gaggatataa aaaatgaaaa
    23401 tctacttgat gaatttacta cattaacaga agcaactcac tggtctggaa caacatatgg
    23461 tgaagaatct aaattaatta cagaatattc tgtacctatg ttggatattg agataggaag
    23521 tagtagtgat agttttaata atagtatagc aatacaggta ttggcaaaat cattaattag
    23581 agtatttgat tgtgatgaac ctttgaagac tttgttatgt gttggagggg tacattttga
    23641 gaaatctttc tcagatatta taaaaaataa agaatataac atatcaattg gacatgtatt
    23701 gccaaatcaa tggattgtaa gtggaatgta tgatgatgaa tctggatttg agaaactaga
    23761 aaagtgtata aatagcattg aaggaggaat tgattgtata gtttttcatg ataaattaaa
    23821 aggtacctat aaagagcaat gccgtaaact aggtgaaaaa cttaatgtac ctgtatttaa
    23881 acataaaata ttaaaaaatc caaaagactt acctatatgg tagtcttata cagttaatat
    23941 aacaataagt cggattaatt tttaagcgag gtcaaaaatg atattatctt attttgcatt
    24001 attaattaga gtagtgctat tagcttttga aagagtagtt gtaagattat taggtgatga
    24061 agaaggagat atttataaaa atatagcttc atcatttcta tttttcttta tagggggagt
    24121 atgtttactt ccatttagca taatggatag agttagtgat tggtcgtttt taataccatg
    24181 ttatataagt agtttagtct attcaattgg ttcagtagcg tatgtaacgt ctttagcaac
    24241 tggggaagtt tcacttgtta ctccaataaa tagtttaaat tcattgtttt tactgctttt
    24301 atcagttata tttttaggtg aaggtttaag tttagcaaaa gttgcaggaa tcataattat
    24361 gattggtgga gtgtttatat taaaaaaagt aagttctttt ttaaagaatg tctctgtaat
    24421 ttttaacaat ttaccatgta gattaatgtt tttatacata tttttgcagt cagtaggaag
    24481 agtattggat aaggcttttt ttgtacaagt atctcctata ttatattcaa ctatactgta
    24541 ttttttcgta ggtttaaatt tatttatctt tttagcattt aaaaagaaac aaaaaataat
    24601 ttgtgagatt tttactaata aaaaggggct ttcaatttta agtggtgcta ttaatggata
    24661 ttcttattta gcattattaa ttgctttaaa taatctagaa cttagtatag cagagccatt
    24721 ttctcaagta tctatgataa taactttaat acttgctcat tttatattca aagaaaatat
    24781 aaaagaaaaa ataccaggtt caattttgat actaattggt gggtggctac tgttacttta
    24841 attgacataa aaaatgaatt ataaaggtgc tattagttag tatcagaaaa tttaaaaaag
    24901 tattgacaat tcttttaggc aaatgttaat ataataatac aaaatagtat aaatagaaga
    24961 catgttactg gtaatgcagg caggatcgaa tatattgctt tgatttttca aggtgtttat
    25021 ataggttctg ccttttttgc atcttgaatg gccattcata aaaaattatg gagaaggaga
    25081 ttacaagatg aattataaaa aaactgccat tgacattatt gaacaagttg gtggttcaaa
    25141 aaatatttta gctttagaac actgttcaac tagactacgc tttaagttga ttgatagaag
    25201 taaagtcaat caagatgctt taaaaaaagt acaaggtgtt atgagtatag ttaatggggc
    25261 acaatttcaa gttgtcattg gaaatagtgt tgttgatgtg tatgatgaaa ttttaaaagt
    25321 ttgcccttta gatacaaatg atagtactgt aaaaactgaa gaaaaaataa acttaggaac
    25381 aagatttata gaatttatta ttaatatttt tcaaccactg atttttgcta ttgcaggagc
    25441 tggtatttta aaatcactgt tgatgttatt agcaatgttt aatattttaa aatcagattc
    25501 tactatatat acattattag ttgctatttc agatgcaaca ttctatttcc tacctcttat
    25561 ggtagctgta actactgcca atgtattgaa atgtaatcgt ttagtagcta ttgccgctgt
    25621 aggatactta ttgcttccag caacaacaac tgctttaagt gaaggtgttg aactatttgg
    25681 atttacaatt ccaaacattg cctataatgc acaggttttc ccggctatct tatgtgtgtc
    25741 tttcttggca acaatggaga aaatttttaa caagtattca ccaaaaccaa ttcgaacttt
    25801 ctttgttcct atgatgtctt tggcaattac tgttccaatt actctaacta ttttaggtcc
    25861 tttaggatat aacgttggta caatttttac aaccattatt ttattcttat ataacaaaat
    25921 gggattctta gttgtaggat tacttgctgc ttttcttcca tttatggttg caacaggaat
    25981 gcacaaagca ctaatacctt attcaattaa tacaattgga aagttgggtt atgaagcttt
    26041 atatatgaca tcttcattag cccacaatat ttctgaaagt ggtgcttgtt ttgcagtagc
    26101 cttgcgaaca aaagatgaaa cattaaaaca aacagcatta tctgcaggaa tttctgcctt
    26161 gatgggaatt acagagccag ctttatatgg tattacctta caacataaaa gagcaatgtt
    26221 aggtgttgta ttctcaagtg caatttctgg taccttttta ggattatttg cagtaaaagg
    26281 atttgtaatt gttggaccag ggcttgccag tatgagtatg tttattgacc caaacaatgg
    26341 aaacaatttg atttttgcga gtattggttt tgttattgca atattaggct cgtttattat
    26401 tacactgatt atttggaagg aagatacaaa tacagtagag tcatcaattg gagatgttgt
    26461 tgaagaagag ctagaagaag aaaaagaagt aaatatctta gtaactccag tagaaggaaa
    26521 agtaatagat ttaagtaagg ttaatgatga actatttgca agtaagactt tgggagatgg
    26581 agttgcaatt ataccaacca atggaaattt atacgcacct tgtgattcag aagttgtgat
    26641 gttatttgaa acaaaacatg caattggttt aagaacaaaa aatggggctg agattttgat
    26701 tcatattgga ataaatactg taagtatgaa tggagatgga tttaaaacat ttgttaagac
    26761 aggcgataat gtaaaagaag gagatttatt aattcaattt gatttagaca aaatctcaca
    26821 tgctaattta gattcaactg ttatgattgt aaacaataat ggagcagatt atgcttataa
    26881 agtgttaaac cagtcttatg gcaatgtaaa aaaaggaagt atcttgtttg atgtaaaggg
    26941 aggaatataa atatgagaaa atttccagaa ggatttcttt ggggaggagc tacagctgct
    27001 aatcaatttg aaggtggttg gaatttaggt gggaaagggt ggtctgtatc agatgtagca
    27061 aaggcacact ttgatgcaga tgtgaaagat tataaatcta ataatgaaat cacaacaaaa
    27121 gatatagaag aaggattagc acatcctgaa gatgaagtaa attatccaaa acgtcatggt
    27181 agtgattttt atcatcacta taaagaagat attgctctaa tggcagaaat gggatttaag
    27241 acatatcgaa tgagtattgc ttggtctcgt atttttccaa atggagatga taaagagcca
    27301 aatgaagaag gtttacagtt ttatgatgat gtatttgatg agttgataag ttatggaatt
    27361 gaaccacttg ttactatgtc acattatgaa ccaccattaa atatcgtttt aaactatgat
    27421 ggatggtatt cacgacaagt tatcaatatg tttgttaggt atgtagaaac tatctgtgaa
    27481 agatataaaa acaaagtgaa atattggctt acatttaatg aagttgattc tatgattcgt
    27541 catccgtaca ctactggtgg tttagttcga gaccgtttta aggataaaaa ctttgaggaa
    27601 gttatttttc aagctatgca tcatcaattt gtagctagtg ccattgcaac aaaaatttgc
    27661 catgagatta ttccaaattc aaaagtaggg tgtatgttaa caaaattaac gtattatcca
    27721 tatacatgta gaccagaaga tgttttggca actcaacaaa aaatgagaag tatttatgca
    27781 tatagtgata cgcaggtttt tggtgagtat ccagtatatt tactgtcgta ttttaaaaat
    27841 aataacattc aaatagtaaa agaagaacat gatgatgaaa ttatgaaaaa gtatccagta
    27901 gattttattt cattctctta ctatatgtct tcttgtgagg cagctgatac aactggatta
    27961 gatattacac ctgggaatac gttattagct gtaaaaaatc cttatttaga aatgagtgaa
    28021 tggggttggc aaattgattc aataggtcta cgtatatctt tgattgaatt atatgataga
    28081 tacagaaagc ctttatttat agttgaaaat ggattgggag ctaaagatat tttaactgaa
    28141 gataaaaaag ttcatgacca atatagaatt aattatttaa aagaacactt taaatgtatg
    28201 ttagatgcga ttatcgaaga tggcgttgaa ctttggggat atacttcatg gggttgtatt
    28261 gatttggtca gtgaatcaac gaaacaaatg tcaaaacgtt atggatatat ttatgtggat
    28321 gctgatgact atggaaaggg gacatataat cgatataaga aagatagttt ttattggtat
    28381 aaaaaggtaa ttgaaaataa tagtatagat tttaaatgac caatagaagg tgagcaaata
    28441 aaatgaacta cataataaag aaagttttga actcgagcgt tgttttagtt catgatgcaa
    28501 agtataatga atttattttg ctagggaaag gaattggata tggtaaaaaa acaggagaat
    28561 atatttgtgg ttccaatgat aatcaaatgt ttgtccctgt tgaaaataca aaatcaaaac
    28621 aatttttaga attaatggat gatattcctg tcgacatttt aaagataaca caggaaataa
    28681 tagtagaggc agaaaagtta ttgaactcat cttttaataa aaacttatac ttaatattag
    28741 cagaccattt taactttgca attgaaagga tgcgtaaagg aataaaaatt acaaatcgag
    28801 tattttggga aataaaaaat tattatccaa atgagtttaa ggttggaatg gttgcaattt
    28861 atatggtaga ggagagattg ggcattcaat taccagagga agaagcagct aacattgctt
    28921 tccattttgc aaatgctatg gcttcagatg gaaattcata tgatacgatt aagtatgcca
    28981 aagtaattgg agaaataatt aatatttttg ttttttcttt gaatagaacc ttagataaaa
    29041 agagtatgca ttatatgaga tttataacac atataaaatt ttttgtggaa agattttttt
    29101 cagatagtat gttaagcagt ggtgatgatt tattatttaa tcaaatgaaa aggtcaaatc
    29161 caaaagaaat gttaattgca ttaaaagtta gagatttttt agaaaagaaa tatggaaaaa
    29221 agttaacaaa tgaggaaata gctttcttgg ttgtacatat cgcacgagtt aagcaataga
    29281 gtgaattact aatattatct tatacgtcta catggtagaa aattgaaaga aggtaaagta
    29341 tataaagaaa ctgagacata ttattttgtt gttcattatg tttattttat gagtgtatcc
    29401 tgttaaaaat ttaagttaat atttataatt aaaatataca aatagttaaa ataagtttat
    29461 gtggttatga atttatttta actatttttt tgtttaatgg aaaatatgtt ttataactag
    29521 aattttattt ttaattaatt ataatacaaa aaactttata aaatcttcag aatttcttaa
    29581 agaatatgta agtaacataa gatatattat atttagttgg taatataaag ggggcaatat
    29641 ttatgaagaa taaaaaattc aatgttataa cactgataat acttgataat catatttatg
    29701 ccattaataa agagcagatt agtactaatt caaaaagaat ttactttgaa aaaagtcgat
    29761 ttttcagtga ttataagtga ataaatatat ataaacattt aataaattta gaagttaaat
    29821 gttttaatac gaaaggatac acatatgata aatttagaag aaaagtattt aacacgaaaa
    29881 gacacatata tgataaaaat tctagaatac aatgggcata ttcgaaactg gaaagttctt
    29941 tgtgaagaac ttggaatcga ttcttcatta tgtagagatg agcgtgaacg agcaatttta
    30001 gtggaagcat ataagacatg gggatatgat atggcaaatc acatgcatgg aatgtttgct
    30061 tttgcattat gggatactgt ggaaaagaaa ctcttctgcc taagagacca gtttggggta
    30121 aaacctttct attattatga gactgaaaat gggaagcttc tctatggttc atctattcgt
    30181 aagattatgg agcaaccagg atttgtgaaa gagttaaatg aagacatgtt acagatttat
    30241 atgtctttca catatgtagc aggtgaaaat acattcttcc gtggagtaaa gaagcttatg
    30301 ccaggacatt accttgtcta tcagaataaa acagtatgta ttggtcgtta ttggaaacct
    30361 gaatttcatc ctgaccacag caagtctatt gaggaatgga cggatgaaat tcatacaaca
    30421 cttcagaaaa ttatgccaga ggtaaaatca gagaatgaaa ctgcagagtt attcctatca
    30481 ggaggtgttg attcatctta tatattggca atgtcagata tagaaaaaac aggttcatgt
    30541 ggttatgagg aagagcgttt tgatgaatca aaattagcac aacagacagc taatattctt
    30601 gggtgtaaaa attcgagata tataattaca cctgaagagt attttgcgtc agtaccttat
    30661 gtaatgtacc atatggagca accaactgga gatgcatctg ctatcgtttt tgctattgga
    30721 tgcaaggcag cagctgaaaa cacaaatatc tgttactctg gagaaggagc agatgagttt
    30781 tttggtggat ataatatata ccataaggca gagtgttatg gagagaattt gaagacattt
    30841 tatattggaa atacaaacat tatgaatgag ggtgagaaaa gaaaaattct taagaaatac
    30901 aatcctgatg tgcttcctat tgaagtggta aaaggaattt atgaagaaac agaagaacta
    30961 gatacactta ctaacatgtc aaatgtagat attcaaatat ggttggaagg agatatttat
    31021 tttaatatag ataaaatgag tactgcagta ggattggaag tcagaatgcc tcttacagat
    31081 acaagaatat ttgatattgc atccagaata ccatcagaat ataaagtgaa aggaaaagag
    31141 aataaaattg cctttcgtac agctgcatca aaaacattac cagaagagat tgcttttaga
    31201 aataaattag gatttattgt gccaattcgt atatggatgg ctgatgaccg atataataag
    31261 gatatccgag ataaattcaa tagtgagata gcagataaat tctttaacat agatgagatt
    31321 aatgagattt ttaatgacta cattagtgga aactctgata attggagaaa gatttggatg
    31381 atttacacat tcctagtgtg gtatgaaatc tattttgtaa aatgttaata caagaggaag
    31441 aatcacctga aataccattc aggtgattct taatgtttta taattttact tgctaattct
    31501 tatgtctaac tcttaatggt atatcaagtt tttttgccag ttgtttagat tcttctattt
    31561 cttctggaga tatttcatct actactgaaa aagctacttc ttttatatat tttttgcaat
    31621 ctcttgcaaa atctaacata taatcaaatg atttttctcc aaactttggt tgagtaactc
    31681 tattataagc ttctttattt ggggcattaa gacttattga tactgcatct ataacatttt
    31741 ttaacagaat agctgttttt ttgttatgta ttaaatcact tagaccattt gtatttattc
    31801 ttatctttat gctacttttt tcttttataa actttgctat ctctatcaat tcatttattc
    31861 tcattaatgg ttcgccatat ccacaaaata cgatttcatc atagtcgtct aaattgtatt
    31921 tattgaaggc ttcttttact tcatctacac ttggctcatg ctccaaccat aaactaccac
    31981 tatttgcaac ttcatctttt tcgtttctta tacaaaaaac acaactacat ggacatgtat
    32041 tagttatatt tacatagata ctattttcaa ttgtatataa gatattcata attttccctc
    32101 cataaattta aattcttaat taaaataacg ttttttaaaa tcaagtttat caagtgccat
    32161 acctaagatt ataaaaacaa taaaacttcc tattggctgt aataagccaa gtaagctcat
    32221 tacaaatgca cttgtaaaac ttccaataat tataccttca gcaaacatgt ataaaactaa
    32281 tcctactata cctgctacaa ccgaagcaac tatatttctc ttatttatta tcttgtcact
    32341 tttagaagtg aaaaataata caagtattgg ttttatgatt atagttggta ttacccagat
    32401 agcagcacct gtagataaat cagctagacc agcaccaatt gcagaagcag ctatagcata
    32461 gtttgttggc aaaatagttg cagctagata aataaaagca tctcctatat gaacatatcc
    32521 attgtttcca ccaactggaa tatgtaatat atatgctatt gtcaggcata ttatggatgc
    32581 aaataatgct gaagtaacaa tataggtagt ttttttagaa gtaactttat tcattttttc
    32641 caatatactc cctccctaaa aatccagagc taacataatt gttatgtttt cttataaata
    32701 tattaatatt aatcatacaa ttttcatagt ttgttaggtg ttttttttgt aaaatacaga
    32761 ttgtacccat tcaaatgtat ataattagaa aagtaaaaat aggtaaaatg tatagagtag
    32821 gagtagttag aataagttaa tataaattta atttggtatg aataagaaga gtacaagttt
    32881 aatataaaaa ataatataag agagtctact caatatatac tgagctgact ctcttatatt
    32941 tgggaaatta aaggctattt tgttagataa tagctaatta atgaaaaaat atatttataa
    33001 aatactaatt tactctatta gtagcagttc ctgtttttat aacttctaca gcactactta
    33061 aactagaata aactatattt tcaatcgctg tactagtgaa gaaaccaagg tgatgagtga
    33121 atataacttg ttccatagaa agaagtttat ttatttctgg gtcagttaat tctccaggat
    33181 tcattttttt gtttaagaac aatccttcag tttcaaatgt atcaagggca gcagctctaa
    33241 tttttcctga ctctagtgct tctattaaat cccctgtatt aattaaacca ccacggccag
    33301 tatttactat gtaagctcca tccttcatta tagctagagt atctttattt atcatatgtt
    33361 ttgttccttc aagtaaagga gtatgtaatg ttataaggtc agcttctttt agaaggtctt
    33421 ctaaagaatc tttgtaagtt aatatatcat ttaaatcact atttggatat tggtcaaatg
    33481 caattacatt agctcctagg cctttgaata attttgcaga agtagcacct atttttcctg
    33541 tacctataac accaactgta atagatctaa cttctgttcc aagaagttca gctatccaac
    33601 ggtaatcacc ttcacagact tttttcttta ctagaggagt ctttcttaaa aggttcatag
    33661 cttgagtaac agctaattca gctattgcat taggtgaata agaaggaacg tttgtaacga
    33721 taagtccatt ttcattaact aaatcaaaat gtatcatgtc aacccctgca gttcttgaag
    33781 ctataacttt aaccccagca tcttttaaag tttcataaat ataaggatta tctatatagt
    33841 tagtttgttg tatagatata ccatcatacc ctttagcttt aactacattt tcttcagtca
    33901 tgttttcagg ataaatatcc acttgaacat ccttatgttc ttcagaccat ttttttatta
    33961 ctggttcttc ataatcgcgt gctccaaata ctagtatttt catatcaata ccctcctgta
    34021 attattaaat tattatggta atttttcatt tagaaataat atgtagcata taaggttata
    34081 ttttttatac aaaattttta aggttaaaaa tttagttttg aaattgtttt ccctgtgtta
    34141 ttttgatatt tagtaatttt ttatttaatg taataattac tctaaaattt atcaaagaaa
    34201 ttgttatttt ttagattaaa tattattaaa aaattatcta agtttgaaat tagttaacta
    34261 acttgctgat taattacaat gataacatgt gtttttgagt ttagcaatga aaactttttt
    34321 tgaaatgtca agctttttca taaaaaaata tataaaaaaa acttttataa gcatagaaag
    34381 aatagcaaaa tgcaatggat agtggcaaga tgccacgata tgaaaaagat tattcaattg
    34441 catattgtta aaaaacattc aaatcaagcg atattttgat taaatataaa gttggcacga
    34501 taaatgctta acaatatagg tgtaagacaa taaaacaata aaaaataatt ttaataattt
    34561 ttaagttatt ttagataaga ttaggaactt tgacatcaga cagttaatat cagaaaaaag
    34621 tattttatga gtgatttaat cgaaatttta taattgatac tattaaggag gaaaacgtta
    34681 tgcttttaga aggagttaaa gtagtagaac tttcaagttt catcgcagca ccatgttgtg
    34741 caaaaatgtt aggtgactgg ggtgcagagg ttattaagat tgaacctata gaaggtgatg
    34801 gaataagagt tatgggtgga acatttaaat ctccagcatc agatgatgaa aaccctatgt
    34861 ttgaattaga aaatggaaat aaaaagggtg taagtattaa tgtaaaatca aaagaaggag
    34921 tagaaatatt acataaatta ttatcagaag cagacatatt tgtaactaat gttagagttc
    34981 aagcattaga aaaaatgggt atagcttatg accaaataaa agataagtat ccaggattaa
    35041 tattctctca aatattagga tatggtgaaa aaggaccttt aaaagataaa ccaggatttg
    35101 actatactgc atacttcgca agaggaggag ttagccaatc tgttatggaa aaaggaacat
    35161 ctccagcaaa tacagcagca ggatttggtg accactatgc aggtctagca ctagcagcag
    35221 gaagtttagc agcattacat aaaaaagctc aaactggtaa aggtgagaga gtaacagtaa
    35281 gtcttttcca tacagctata tatggaatgg gaacaatgat aacaacagca caatacggaa
    35341 atgaaatgcc tttatcaaga gaaaatccaa acagcccatt aatgactaca tataaatgta
    35401 aagatggaag atggattcaa ttagctttaa tacaatacaa caagtggtta ggcaaattct
    35461 gtaaggttat aaatagagaa tatatattag aagatgatag atataataac atagattcaa
    35521 tggttaatca tgttgaagat ttagttaaga tagttggaga agctatgtta gaaaaaacat
    35581 tagacgagtg gtcagcttta ttagaagaag cagacttacc atttgaaaaa attcaaagct
    35641 gtgaagattt attagatgac gaacaagctt gggcaaatga cttcttattt aagaaaacat
    35701 acgatagcgg aaatacaggt gtcttagtta atactccagt tatgtttaga aatgaaggaa
    35761 ttaaagaata tacaccagca ccaaaagtag gtcaacatac tgtagaagta ttaaaatctt
    35821 taggctacga tgaagagaaa ataaataact ttaaagatag taaagttgta agatattaat
    35881 tagtaattct agatttttta aaaggagaat gctaaagatg tacacaatgg gattagatat
    35941 aggttcaact gcatcaaagg gagtaatctt aaagaatggg gaagatattg tagcttctga
    36001 aacaatatcc tctggtactg ggactactgg accatcaaga gttttagaaa aattatatgg
    36061 caagacaggt cttgcaagag aagatattaa aaaagttgta gttacaggat atggaagaat
    36121 gaactattca gatgctgata agcaaataag tgaattaagc tgtcatgcta gaggggtaaa
    36181 tttcataatt ccagagacaa gaaccattat tgacataggt ggtcaagatg caaaggtatt
    36241 aaaattagat aataatggaa gactattaaa ctttcttatg aatgacaaat gtgctgcagg
    36301 tacaggaaga tttttagatg taatggcaaa aataatagag gttgatgtat ctgaactcgg
    36361 aagtatatct atgaattctc aaaatgaagt atcaataagc agtacatgta cagtatttgc
    36421 agagtctgag gttatatcac atttatctga aaatgcaaaa attgaagata tagtggcagg
    36481 tattcatact tcagtagcaa agagagtttc tagcctagta aaaagaatag gagtacaaag
    36541 aaatgtagtt atggttggtg gagttgctag aaatagtggt attgtaagag ctatggcaag
    36601 agaaatcaac acagaaatta ttgtacctga tatacctcaa ttaactggtg ctttaggagc
    36661 agcgttatat gcttttgatg aagcaaaaga atcacaaaaa gaagtgaaaa atatataaaa
    36721 agagggatga aaatgtctga aaaaaaagaa gctagagtag taattaatga tttattagct
    36781 gaacaatatg caaatgcatt taaagctaaa gaagaaggaa gacctgtagg ttggtcaaca
    36841 tcagtatttc ctcaagagtt agcagaagta tttgacttaa acgtattata tccagaaaac
    36901 caagcagctg gagtagcagc taaaaaaggt tctttagaat tatgtgaaat agctgaatct
    36961 aaaggatatt ctattgacct atgtgcatat gcaagaacaa attttggtct tttagaaaat
    37021 ggtggatgtg aagctttgga tatgccagct ccagatttcc tactttgctg taacaatata
    37081 tgtaaccaag ttataaaatg gtatgaaaat atttcaagag aattagatat acctttaata
    37141 atgattgata caactttcaa taatgaagac gaagttactc aatcaagaat agattatatt
    37201 aaagctcaat ttgaagaagc tataaaacaa ctagaaatta tatcaggaaa gaaatttgac
    37261 cctaagaagt ttgaagaagt aatgaaaata tcagctgaaa acggaagact atggaagtat
    37321 tctatgagtt taccagcaga ttcttctcct tctccaatga atggatttga cttatttact
    37381 tacatggctg taatagtttg tgctagaggt aaaaaagaaa ctacagaagc atttaagtta
    37441 cttatagaag aattagagga caacatgaaa actggtaaat cttctttcag aggggaagaa
    37501 aaatacagaa taatgatgga aggtatacct tgttggccat atataggata caagatgaaa
    37561 acattagcta aatttggagt taacatgaca ggtagtgttt acccacatgc ttgggcatta
    37621 caatatgaag ttaatgattt agatggaatg gcagtagcat atagtactat gtttaacaat
    37681 gtaaacctag accgtatgac aaaatataga gttgattctt tagtagaggg taaatgtgat
    37741 ggagcattct atcatatgaa cagaagctgt aaacttatga gtttaataca atatgaaatg
    37801 caaagaagag cagctgaaga aactggatta ccatatgctg gatttgatgg tgaccaagca
    37861 gaccctagag ctttcactaa tgctcaattt gaaacaagaa ttcaaggttt agttgaagta
    37921 atggaagaaa gaaaaaaact taatagaggt gagatataat ggaagctatt ttatctaaaa
    37981 tgaaagaagt agttgaaaat ccaaatgcgg ctgtaaaaaa atataaaagt gaaactggta
    38041 aaaaagctat aggttgtttc ccagtttatt gcccagaaga aattatacat gcagctggaa
    38101 tgcttccagt tggtatatgg ggagggcaaa cagaattaga tttagctaaa caatatttcc
    38161 ctgcatttgc atgttcaata atgcaatcat gtttagaata tggattaaaa ggtgcttatg
    38221 atgaattatc tggagttatt ataccaggta tgtgtgatac actaatttgt ttaggacaaa
    38281 actggaaatc agcagtacct catataaaat atatatcatt agtacaccca caaaatagaa
    38341 aacttgaagc tggtgtaaaa tacttaatca gtgagtacaa aggcgtaaaa agagaacttg
    38401 aagaaatttg tggatatgaa atagaagaag caaaaattca tgaaagtata gaagtttaca
    38461 atgaacatag aaaaactatg agagactttg ttgaagtagc ttataaacat tctaatacta
    38521 taaaaccatc aataagaagc ttagtaatta agagtgggtt ctttatgaga aaagaagaac
    38581 atactgagct agtgaaagat ttaatagcaa aattaaatgc tatgccagaa gaagtctgtt
    38641 ctggaaagaa agttttatta acaggtatat tagctgattc taaagatata ttagacattt
    38701 tagaagacaa caatatatca gttgtagctg acgacttagc acaagaaaca agacaattca
    38761 gaacagatgt accagcaggt gatgatgcgt tagaaagatt agcaagacaa tggtcaaaca
    38821 tagaaggatg ttcattagct tatgacccta agaaaaaacg tgggtcactt atagtagatg
    38881 aagttaaaaa gaaagatata gatggtgtta tcttctgtat gatgaaattc tgtgacccag
    38941 aagaatacga ttatccttta gttagaaaag atatagaaga tagtggaata cctactttat
    39001 atgttgaaat cgaccaacaa actcagaata atgaacaagc cagaactcgt attcaaactt
    39061 ttgctgagat gatgagttta gcgtaagttc attaaaataa atttactata aaatatgaaa
    39121 attggaggaa gctatgttat ataacaaaga acaagaactt ttaagaaaag cagtaagaga
    39181 ttttgttagt aaagaattag atactttacc agcagaaatg gataaaacag gtgtaatgcc
    39241 taaggaatta atcaaaaaat tagctgatgc aaaatttata agcagtaata tcccagaaga
    39301 atatggtggt gggggagcag gatatgtttc ttacgctata gtaatggaag aaatagctag
    39361 aagatgtgct tcaacagcta cttttgttac agctggttct tctcttgctt cattaccaat
    39421 actttacaat ggtactgaag agcaaaaaca aaaatactta aaaggtatag caacaggtga
    39481 attaatagga gcatttggtt taactgagcc aggagctggt tctgatgcag gtggacaaca
    39541 aacaacagca gaattagttg gagaccacta tatattaaat ggtagaaaaa ctttcataac
    39601 taatggacca ttctgtgatg tagctatagt aatagcagtt acagatagaa gtaaaggact
    39661 tagaggaaca tcagcgttta tagtagaaag taaatgggat ggtttctcaa caggagctca
    39721 tgaagataag atgggtataa gaggaactga aacttctgac ttaatatttg aaaacgttaa
    39781 agttccaaaa gaaaacttac ttggaaaaga aggtcaagga tttaagatag caatgggtac
    39841 tctagaagtt ggtagaatag gtgttgctgc cttagctcta ggaatagctc aaggtgcttt
    39901 agatgaagct gttaaatata caaaacaaag agttcaattt ggtaagccta tagctaaatt
    39961 ccaaaatact caatttacta tagctgacat ggaaacaaaa gtttgtgcag ctagaggatt
    40021 agtttatgat gcagcacaaa agagagatgc aggaatgaga gttgctcaag aatctgctat
    40081 ggctaaatac tatgcatcag aaattgcaaa tgaagttgct tataaagcat tacaacttca
    40141 cggtggatat ggatttataa aagattatga aatcgaaaga atgtacagag atgctagaat
    40201 cgtatcaata tacgaaggaa catcagaagt tcaaaaaatg gtaatttcat caaacgtatt
    40261 aaaataataa ataatctaat gaaattggag gtatagactt tgaaaatatt agtttgcgta
    40321 aaacaagttc cagatactaa cgaagtaaga ataaataaag aaacaggtac tcttataaga
    40381 gatggagttc caagtatatt aaacccagat gatgcaaatg cattagagga agctttaaaa
    40441 attaaagatg agcatgatga tgtaactata acagttataa caatgggacc tcctcaagca
    40501 gactttatgc taagagagtg tttagctatg ggtgctgatg atgcaatatt attaagtgat
    40561 agagcatttg gaggagctga tacttgggct acatcaaata ctattgcagc gggaatatct
    40621 aaagtaggtg actatgacat aatatttgca ggaagacaag caatagatgg agatactgca
    40681 caagttggac cacaaattgc agagaaatta gacattcctc aagttacata tgtacaagat
    40741 ttcaaaatag aaggaaaaga tataatagtt caaagacaat tagaagatgg atacgaatta
    40801 ataaaagtaa gtacacctgt acttttaaca gcagtaaaag agttaaatac acctagatac
    40861 atgtctgttg ataaaatagt aaaagcatat aaacatgatg taaaagtttg gacaattgat
    40921 gatttagatg taaataaaga agaagttggt ttaaaagcat caccaactaa agtatttaga
    40981 tcatttactc ctgaaccaag aggaaaagga gaaatcttag aaggtaaagc tgatgaaata
    41041 gctagtaaaa taataatcgg tctaaaacaa aagcacatta tataagttgg aggagtacaa
    41101 actatgaatg atataaaaga tttaagttct tataaaaacg tatggatatt tgcagaacaa
    41161 agagaaggaa aaatagctcc agtagttata gaattattag gagaaggaag aaaattagct
    41221 aaagaagtag atgcagaact ttgtgcaata ttattaggaa aagatgttga tggattagct
    41281 aaagaattaa tcacttttgg agctgacaaa gtttatgttg cagatgatgc tcttttagaa
    41341 aaatatacaa ctgatgcata tacaaaagta ataaaagatg caatagatga aataaaacca
    41401 gaaataatgc ttttcggagc aactcatata ggtagagact tagcacctag aatagcttca
    41461 agagttggaa ctggattaac agctgactgt actaagttag aaatagaccc agaagataag
    41521 aaaataaaac aaactcgtcc agcatttggt ggaaacataa tggctacaat catttgtcca
    41581 aaccatagac ctcaaatgtc tacagttaga cctggtgtta tggataaagc tgaaaaagac
    41641 gaaacaagaa ctggtgaagt tatagcatta gactacaaaa taactcaaga tgatataaga
    41701 actactgttt tagaaacagt taaaactaag aaagatttag tatctcttac agatgcaaat
    41761 gttatagtat caggtggtct aggattaggt ggaccagaag gatttgaaat gcttaagaaa
    41821 ttagctgaca aattaggtgg agtagttggt tcttctcgtg cggctgttga tgctggatgg
    41881 atagaccatt ctcaccaagt aggtcaaaca ggaactactg ttaaaccaaa cctatatata
    41941 gcttgtggta tatcaggagc aatacaacat ttagcaggta tgcaatcatc agatttcata
    42001 attgctataa acaaaaaccc agcagctcca attttagaaa tcgctgacta tggagtagtt
    42061 ggagacttac atgaaatagt tccaatgctt atagaaaaat tagatagcgt tgatgattta
    42121 ttagaagcta taaaagctta atagatacaa actatataaa tattactgat tgaataagtc
    42181 ttattagtta gtaacataat tattaaccct ttgataagtt attgctagtg tgtatttgtc
    42241 agttattaaa aagtctgttt gaataaaatt ttataataca agataatctg gataatcctt
    42301 atatgtatat tgcttacaaa ttgtgagtta tattctgtaa ggattatctt tgttttttta
    42361 aataaatctt aaatttaatt aaattgtatt aaatagacaa ataattacta aatatgtgat
    42421 aaaatacaat taaaagcaaa atgaaatttt taacaaacta taatcattaa aattatatct
    42481 tagttacgtt ttaatgaaat aaactacttg aaaagacgaa tattataagg agttgattat
    42541 atgtgctgat ggtatttatt gtaagcaaac aataaatttt gtatgtagtt caataaatta
    42601 cttaatgaaa ggtgcgaata ttaatggata ataatttaat agggcttata gaacatgtag
    42661 aaaatccagc cattttatgt aaagaatcag gcgaaataat atactgtaat catctaatag
    42721 atagtatttt tagttttcta gatataaaaa agcctagaaa tataaatgaa ttagattcaa
    42781 attttgacaa aacagaaata ctgacagata gtaaaaagaa aatagctttc agagagttaa
    42841 ggatgactgc acatatatac aatatgaaag ataataataa tgaaaataat atagtttatt
    42901 tatttgagaa gtctctaata tctgataaag taattgaaga tataatagag catatagatg
    42961 aagttgttgt tgtgtttaac aaagatgggg taattgaaaa gatgaacact gtcagtgatg
    43021 agatattacc ttttaaaaga actgaggtac ttggtagaaa tataacagac cttgtgagac
    43081 aaggattagt tgaagaacca ataatattaa acatgcttaa agtgaagaaa aagatttata
    43141 gaaatatcgt ttacccagat gggaagctta ttgcatatac ggcagttcca agatgggatt
    43201 ctaagggaaa gcttacagga ggagtactaa cagggagaga tatttcaagg gttattaagc
    43261 ttgaatctca gataaaatat agtgatatat cagaagacac agagtatata agtcaaagta
    43321 agattatgga caatataaaa aaagttgtta agagagctgc agcctcagat tcttctatat
    43381 ttataaatgg agaatcaggt gtaggaaaag aaataatagc aagaacaata tataagtata
    43441 gttcaaggag agacaaacct tttatagcta taaactgtgg agctatacca aatgaattat
    43501 tagagtcaga gttttttgga tatgaagaag gttcttttac tggagctaag aaaaaaggta
    43561 aaaagggact ttttgaagag gcgaatggtg gaactatttt cttggatgag ataggtgagt
    43621 taccaatgca gatgcaaaaa aaattactta gggttataca agaaaatact attactagaa
    43681 taggtggtag taagcctata aaaatagatg ttagatatat aagtgctact aatatttctc
    43741 atgaagacct tagaaataac cttaaattta gacaagattt gtactataga ttaagtgtta
    43801 ttccagtaaa aatacctcct cttagagaaa gaaaagagga tatagtacca ttagtaaatt
    43861 atttcttaaa actttacaat gaaaagtaca atagagaagt agaagtttcg cctaaagtta
    43921 ttgagttatt agaagaatat tcttggccag gaaacataag agaattaaaa aacatcattg
    43981 aaagatttgt agtattatca gctaaaaatg taattggaga agatgaattt aacatgctga
    44041 taaatttaga tatgattgat aatgaaacag atgatttatc accaatagtg gtaaatggaa
    44101 ttatgaatct taatgatgca tataaaatag tggaccaaat aatgataagt aaggctataa
    44161 ataagtatgg ttcaataaca aaggctgctg aagttatagg tatatatcct tctaccatcc
    44221 atagaaagat aaagagtgga catattcacg tttagctgtc agtttaaaaa gacaatataa
    44281 ttaaaatatt ataagataca taatttatac aacttaaaag agatggctta aaaataaatt
    44341 taattacttt aagtcatctc ttttctttta taaatattta aaagttatat tagtttatag
    44401 agttagcaga acctaaaaca tcatctatct tgctttcaac tacagcttgt atagcatctc
    44461 taccagcacc aatgtatttt cttgggtcaa attcttttgg attttcagct aagaattttc
    44521 tgatagcagc agtcatagct agtcttaagt cagtatccat gtttatttta caaacagcca
    44581 tagaagatgc ttttcttaac atatctacag gtacaccttt agcaccagct atatttccac
    44641 caaattcatt acatgtagca acagcgtttt ggtcaacagc agatgcacca tgaagaacta
    44701 ttgggaaacc tggtaatttg ctttggattt cttctagtat atcgaatctt aatttagctt
    44761 ctcctttgaa tttgaaagca ccatgagaag ttccaatagc tattgctaat gaatcaacac
    44821 ctgttctttc aacgaactca actgcctcag ctggttgagt atacttgtga acatcagaag
    44881 taacatcatc ttctgttcca gctagaacac caagttctgc ttcaacaaca acacctttag
    44941 agtgtgcata ttcaacagct tctttagtta ttctaacatt ttcttcaaag tcaaaatgag
    45001 aaccatctat cataactgaa gagaaaccag catcaataca agttttaata gcatccatat
    45061 ttggaccatg gtctaagtga agagctacat ctacacctat ttcatcagaa gcagccttaa
    45121 ccatttcaac taatgtatga ggtccagcat atttaacagc tgacatagaa gcttgtatca
    45181 taacataaga atttttagct ttagcagctt ttaaaacacc ttgtaattgt tctaagtcac
    45241 ttatgttaaa tgcacctata gcaaatccac cttcgtaagc ttttttaaac atttcttttg
    45301 tagtaattaa tgccatttta aactcctcct attaactttt aaaatttacc catcacttat
    45361 attataacgt taaatcaaaa aaagtatata gtaaattgta ataactataa attacaagta
    45421 taatgttaaa tagaagacaa taggattaaa taaaataata aagaatataa acaatttagg
    45481 aaaactagct atataatgct aactataagg gtaggaacta ccttattagt ttggagatac
    45541 tgataacaat agttgccttg accaagaagt taccacttca aacgttatcg aaaggaatta
    45601 agtggatgat aatttactaa aaatttaaaa taaaggagat aaactatgcc acagataaaa
    45661 ataagaggaa ttaatgaaaa tgatatatgt aaaataagtg aaaaaatgat aaatgattta
    45721 gttgaagctg taaaatgtcc aagagactac tttgaaatag aatgtataaa gtcagttgca
    45781 ataagagatg gtaaaatagc agatgtatat ccttttgttg aagtagcttg gtttgataga
    45841 ggacaagaag tacaagatat agtagcaaga ataataactg atagtataag aaataattta
    45901 gatgtagaaa gtatagattt agcatttaca gtatttgaaa aagaaaaata ttatgagaat
    45961 ggagagcatt tttaatggct aaaaagcaac gtatagataa aattctttca aatttaggtt
    46021 atggaagtag aagtgaaata aagaagtatt gtaaacaagg gtctgtagta gtaaatggaa
    46081 gtgaagtttc aaatccagga actcaagtag acactgaaaa tgatgagata ttatttaatg
    46141 gagaagaagt tatatataga gaatatatat atttgatgat gaataaacct gatggatata
    46201 tatcagcaac tacagataaa tatgacccaa cagtattaga tttaattgat ttatcatact
    46261 tagcttttga accatttcct gttggaaggt tagataaaga cacagaggga ttattagttt
    46321 taactaatga tggaaagctt tctcatagag ttttatctcc taagaagcat gtgcctaaga
    46381 cttattatgc aaaaattgat ggagtagtta ctgaagaaga tgtagaagct tttttagaag
    46441 gtgtagtgct tgatgacgga tataaaacta tgccatcaca gttaaatata ttaaaaagtg
    46501 atgatgaatc agaaatagag cttacaatac atgaaggtaa gtttcaccaa gtaaaaagaa
    46561 tgtttgaaag cgtaggcaaa aaagtagtat acttaaaaag attgtctatg ggcaatttaa
    46621 aattggatga aagtttagag ttaggtgagt atagagagtt aacagatgaa gaagtaaaat
    46681 tgattgaaga aagataataa agatactata gtaaattgga ggaatgtctg tgaagaaaaa
    46741 agatgttata gaatttgaag tagataaaat ggaatttggt ggtacatctt taagccaagt
    46801 tggagataga gttatccata tgaagggtgg aataagtggt caaaaggtga gagctggagt
    46861 taaaaaagtt agaagtaaga aagctgaagt taagatgata gaattattag agaactcacc
    46921 acttgaaact gaagaaactt gcaagcactt tagagagtgt ggaggatgta cactattgtc
    46981 tgtgccatat gaaaaacaat tagaaataaa agaaaaacaa gttatggatt tatttttaaa
    47041 gcaagattta tttggatttc agtttttagg gatagaagga agtccagaaa acaaatatta
    47101 tagaaataag atggaatata cttttggaga tgaagtaaaa aatggacctt tgacattagg
    47161 tcttcataaa aaaggaaagc atatagatat acaaactgtt gaggagtgta tgttggttga
    47221 tgaagacttc tcaaagatat tagtttctag tgtagagttt ttcaatgaaa aaaagcttcc
    47281 ttattataga acaatgaatc acaaaggata tttgagacat cttgtagtta gaaaagggat
    47341 tcatactaat gagattatgg ttaatatagt aacttcttct caagaagatt ttgatatgta
    47401 tgagtttaaa gatatgcttt tagggattga tttaaaagct gagttagtag gtgtacttca
    47461 tactattaat gatggtttag cagatgcagt ccaatgtgat gagttaagag tattgtatgg
    47521 aagagattat atacaagaag aaattttagg tcttaagttt aagatttcac cattttcgtt
    47581 tttccaaacc aatactaagg gagcagaggt tctttatagt attgctaggg attttattgg
    47641 agattacaat gataaagttg tatttgactt gtatagtggt actgggtcta ttggacaggt
    47701 tatggctggt gctgctaaga aagtgtatgg tattgagata gttgaggaag ctgttgttgc
    47761 tgctaatgag aatgctaagt tgaatggact tactaattgt gagtttattg ctggggatgt
    47821 ggctaaggtt gttaaggatt taaaggacaa gcctgatttg attattgttg accctcctag
    47881 accaggcatt cataaggatg ctattaggga tatttgtgga tttggtgcta aggagattgt
    47941 ttatatttct tgtaatccta agtctttggt tgttgatttg gttgatttta aggggtatgg
    48001 ttatgagatt aagatggtta agtgtatgga tatgttccca aatacgccac attgtgagac
    48061 tgtagtgttg ctacgtcgaa aataatgcta gaaatcttga gctttagaca gtttcataga
    48121 catataatat ttagattaga gggtaataaa attaggaata aagaattgaa aaggtgtttt
    48181 gatgtgtctg tagttatata tatggagtgt gggaatacga aataaaaaaa gttttaatta
    48241 tagaaataga tattaaattt ataaatttaa tatctatttt ttatgtgaaa atatatttaa
    48301 tctaaagaat gatatttcat aaaaaaaatt aaatatattt ttaaaatatt tacaatagag
    48361 ttatttttta ttcgtataat aatagaaata ttttagcata agatgtataa taaaggaaaa
    48421 aatacagaat taaaaaacat aagatagata agtggactta ggggagagaa attattatgc
    48481 aattgacaaa aataattctt agtaactata ggtgttttgg agaagaacct acaactattg
    48541 aaattaataa tttaactgga tttataggtc ataatagcag tggtaaaact gctttattaa
    48601 gtgcacttat gaaacttttt ggagaaaagt ctagtgatag aattattgaa agatcagatt
    48661 tccatatacc tgaaagtatt gatccagata gtatttctaa gaatgaatta tatattgaag
    48721 cacaatttga gtttcctgaa ttggagagag gtaaagacag catatctata ccagtatttt
    48781 ttaaaaatat ggttgttagt gaaccaggtg ggaaacctta tttaagaatt agacttgaag
    48841 caaattggga gaaaagctca aatcctgaag gaagtattga ttcaaatgta tactatataa
    48901 catctacaac agaggagata aatcctgaag ataagcgtaa tatcaaaaga tatgagcttg
    48961 atcaaataaa gatgatttat gtacctgcca ttaggagacc agatgaacag ttaaaaaatg
    49021 tctcaggaac aataatttca agattattaa atggtataag ttggtcagaa caaacaaagg
    49081 caagaattaa aacgaaagca agtgaaacgg aggaaatttt ctttgaagaa aaaggggttg
    49141 aatcattaaa gaaatcactc gaaactcaat ggaatagtta tcataaggat attagatatt
    49201 ctaatccaaa gataaacttc aatagtactg atttagagac aattttaaaa aaagttgaag
    49261 taactttttc acctacaggg acacatcgag attatcgggt tgaagagctt ggagatgggt
    49321 tacgttcttt attttatctt tcacttgtaa atacattttt agaaattgaa gaagaaattc
    49381 taaaatctat taatgatggt aaagaagaag atatatttac attaataccg cctgtattaa
    49441 caattgttgc ggttgaagaa ccagaaaatc atatttcacc tcatctttta ggaagggtag
    49501 ttgaaaaatt aaattttatt tctacaaaag aaaattcaca gacaatattg acatcacatt
    49561 caccagcaat agtaaaaaga attgaaccaa cagacataag gtattttagg atttgtaagg
    49621 aatatgaatg tacaaaagtg aagtcaatta tattaccaaa tgaagaaaag gaagcagaac
    49681 aatttaaatt tgtaaaggaa tcagtattag catatcctga actttatttt gcaaaacttg
    49741 ttgtattggg cgaaggtgat agtgaagaga tcattattaa gcagatgatt gaattaaaag
    49801 cagaatctgt agattcatca gaaatttcaa tagtaccatt aggtggtagg catgttaatc
    49861 atttttggcg tttattaaat gatttagaaa ttccatttat tactttgtta gatttagata
    49921 gagaacgaga tggaggtggt tggggacgta taaagtatgc aatacaacaa ttaataaata
    49981 ttggtcatga taagaatgta ttactttata catgtgaagg aatttcacaa gataatgaat
    50041 ttaaagagat gcatacttgg gatgtaactg atactgaaaa tatggctaaa tggattgaaa
    50101 tgctaaaagg ttatgatgtt tatttttcag ctccgttaga tatagatttt gcaatgttac
    50161 aaagttttaa agataaatat atttcagcat taacaagtgc ggaaggtcct aggataaaag
    50221 atcatggaaa aatacaagat attgtgatca atgaagatgc tgaagatgaa tcattgaaag
    50281 ctgcttataa agatagaata gatagtgata ttaaatcaac cttaaaacaa gaaggtggtg
    50341 atggatctac ttatactgag ggagagaaag aactaatgat atggtattca tatttctttt
    50401 taggaagagg taaaccaact actcatttat ctttattttc taataatact gatatagatt
    50461 ttgaaagttt tccatactgt ctaaaggagt ttgtaaatag tattattgaa aagatgatag
    50521 atgattcagg gggtggaaga aaatgaagag gaattgggtt agtaaagaag attggagtcc
    50581 agcggctgga ttcagactag aagttgaagc gatgaataca gttattaatg ataagaatac
    50641 acttgttgta gctggtcctg gcgctggaaa aacagagtta ttagctcaga gagcctgctt
    50701 tttactagag actaatacct gtagatatcc taaaaaaatc cttgctatta gttttaaaaa
    50761 ggatgctgct gaaaatttaa aagagcgttt agaattgaga tgtgggaaag aattagcttc
    50821 aagatttgaa tcaaagacct atgatgcttt tgcaaaagaa atcgtagata gatttagaaa
    50881 tagtttagat gaagcatata gacctttaaa taattacaat atagctgaaa atcgtgatgt
    50941 tagaagagca tttgagatag caggattaaa tttcagagga aatcaaactg aatttaataa
    51001 agtatatgga aataaactat cgataaataa attgccttta catacagatt ttgtagataa
    51061 gatttttata gatgcttgga atgtactact taaaggcaac aaagatacta attttgtaag
    51121 ttcacttact tttggtatga tatcacgttt agccgaatat ttgataagaa ccaataggta
    51181 tattaagaaa gcaattgaaa tgacttatag tcatgtgttt ttagatgagt ttcaagatac
    51241 taaatctatt caatatgatc ttgttaaagc ttgttttttt aaaacagaaa caataattac
    51301 tgctgtaggg gatggcaaac aacgaattat gttatgggct ggtgctagaa agtcaatatt
    51361 tgaagatttt caaaatgatt ttttaagtca aaaaagaaca ttaattatga atcatcgttc
    51421 agcgccaaga cttgtagaga ttcaaaaagc aatgtataac agtttgaatg aagaggcaat
    51481 tgatttaaaa actaatgaaa agtggaatta tgaagatgga gaagtgtatt taagactttt
    51541 tgaggattat ataaaagaag ctgatatact tagtgaggaa atagtcgaat tggtggaaac
    51601 aggtatagaa attaatgaaa tatgtatatt agtaaaacag agcgtagata tttattcaaa
    51661 agagattata aataaacttt ctgaacgtaa tattaaggcg cgtaatgaag caatgtatca
    51721 ggagatatta aaagaagata taataaagac actggtttcg ctttttaggt tgtcgttaag
    51781 tgatagaaat cccgatgatt gggattatat ttacgatatt ctaggtgaat tatatggaat
    51841 agacgaaggg tataacccta aaatattaaa tgatttcatt accaaagtag aattaatgat
    51901 taatgatctc aaggtaaatt taaatattac tgatgaaaaa caattttcag atttagttga
    51961 ttctaaggtt gaatatattt catatgaaaa atttgcatca aagtttcaaa aatataaatc
    52021 taaagattat tttgatgatt tggtagataa atttaaaaag ctggtatgga ttgaatataa
    52081 tgaaactaaa gattggatta aagcgattga taactttgaa ggtaaaaatt caattccaat
    52141 aatgacaatt cataaaagta aaggacttga atatgatact atcttttttg ttgggttaga
    52201 agattcagca ttttggaatt ttaaaaatca accagatgaa gatagatgtg cattttttgt
    52261 tgcattatca agagctaaaa gaagaattga ttttacattt agcttagata gaccagcagg
    52321 attttcgaat tcacagaagc attattgtat taatgaattc tacgaattgt ttgataatac
    52381 tgagattgta aaaaagatag agtattgatt aagatgataa aaactttagt atattatatt
    52441 ttaagatatt agttatataa gtagacattg aatttatgta tttgatgtct attttttata
    52501 taaaaatata ttaaagaaag gatgaatttg catgaagaaa aaaacaaaaa tatctaaaaa
    52561 gattgtaagt tttattatgg tttttataac tatagttact actatactta catcatcagt
    52621 ttcagcttat gctagcgagt tggatatgag tgaacagaca ggctttaatt atttaggtat
    52681 tagtccaatt acaggaaaaa aattaatcat aacatttatc gtatgaagat ggataataaa
    52741 attgtatttt gtgtagagcc aggaattaaa acttcaagtg gaggaggata tatatcggag
    52801 gagttaggag ataaatttat atctacaaca cttccaaatt atcataaaag aaaagctgaa
    52861 atacttgaga aggtaaatag acataatata ttaccttcat ggaataatga aaaagttgca
    52921 gttaaaagtg gagaaacaat tgagttagaa gataagaatg gtattattag agaaatgcaa
    52981 ttagaatcaa ataatactgg aacagatata ttacttgaag aaaatacttt gaaaattaca
    53041 gcaaataaaa attctaattc aggagttatt agttatataa agattcctaa aaatgaggtt
    53101 ggaatatcaa tagtttatcg taagcataac tatcaaagct tatcagaatt tcatatggaa
    53161 agttcgatga gtgcaaattt aaatataaat gtaatcaagt taggaattgt taaagtaaaa
    53221 aagattgatg aaggcacagg aaaggaatta gcaaatgcaa aacttagatt tgagtatgat
    53281 ggtgatagta aagaaattat aacgggttct aatgaaattg ctagtataga agatattatt
    53341 ggttgattaa aaagtgaagt atacttttgt atctatgaaa aagactataa gcaatatata
    53401 aaattagata tacctattga tgaagcaaaa ataaaaaata gatttgaaat aaggttaaaa
    53461 aatgaaagag catatcatgc agcagttgat ttgttagcaa atagagatga agaaaagaca
    53521 gcattttcaa ttattaatcg ttatatacgt tttgttgata aagatgatga aaaaattaga
    53581 agtgaatgga aaactaatga tcagtggagt tattttattg gtgaaggtag agcgaagtta
    53641 aaactaacaa caaatccaga accatataat attcaaaaaa ctttaaattg gttatcaaga
    53701 caagttgcac caacgttaaa aacaattaaa aggttagata gtttgaacaa ctcaacatta
    53761 attgagggct taataaggta tgcaagacta acagataaac ataaaaaaat aattgaacaa
    53821 aattcagtaa atgttgaaga cattatttat gatgaataaa aaaatgtaat tagtattgca
    53881 gattttaata taaaagaagg gagatatacg aatgaatttt ggtcaaaatt tatataatta
    53941 gtttttatca aatgcacaat cattggtatt aatggctata gctataattg gtgtatattt
    54001 aggatttaag agagagtttt caaaacttat aggattttta gtagttgcat taattgcagt
    54061 agggcttgtg tttaatacag caggagttaa agatatatta ttggagctat ttaataaaat
    54121 aataggtgtg taaggattaa aagagaatag aaaattatga gtatatgatg aagggttcta
    54181 ataagtttta ttaaaatata tattgaaaga caagtagagc tatttcgagt tattacatgt
    54241 aatgctaata tatataactg cattttggaa attaaataca taattagaaa tagcaaattt
    54301 tataggtgac ttattaatat gtttacttat tgtatactat ttgatatatt taatatgagg
    54361 tgattcttga aaatggacat agtgaaagtt tttgctaaca atgtgagaaa atatagaaat
    54421 aaaaaaggtc tatcacaaga agcttttgct gaaaaagctg gattgcatag aacttatatt
    54481 tgtgctattg aaagaaaaaa gagaagtatt gctttagata atgtgcagaa aattgctgat
    54541 gcgcttgaga ttgagactta cttactattt atagaaggtg aggagaaaga atgtctatga
    54601 aaaaattacc aatagaaaag cttatagaaa atttaggttt ttcagggtca aagaatcttg
    54661 tgaatataga tatgcttaca aaattagata tatctaaaca tgatgtaaaa actttaaaag
    54721 ttataaatcc ttatgcaatt tatttagtaa atagtaagcc atttatatta tttatagagt
    54781 cttcttttga agaaaaaaaa ttacaacaaa ttagtaagct tatatggaat gctcaaatac
    54841 caattgcttt tatatgcgat tctaattctg ttaaaatatt taatggaaaa gctttggatt
    54901 taaagtcata tttaattgag gaaatatata atcaatctat tgaggatttt tcggaagaat
    54961 ctgagttttc ttatttgaaa atatctgatc cattattttg ggatcaatac actaaacaat
    55021 ataccaaaac gcatttaaat gattatttgc tagataatat tacttcattg acaaataaat
    55081 taaagaaaaa atataaggtg aaatttgcaa cgaagcttgt tctaagatta atatttatta
    55141 gatatttaat cgatagaggt gtcgatatag cttataaaaa ttttaatcat gatattaaag
    55201 cttcacaaaa agaactgcta aagattacta aaaacaaagt tgaattatat gaactgttta
    55261 aatacttaaa agaaaagttt aatggtaatt tatttgagtt aaatgacgaa attaataata
    55321 cttgtttaac agatgaagtg tttattttac tatctgattt tttatcaggt aaaataagta
    55381 ttgacaatgg acaaatgtct ttattttcaa tgtatgactt taatatcata ccagttgaac
    55441 taattagtaa tatatacgaa attcttttag gaaaagaaat tcgtaataaa gataacgcat
    55501 tctatactcc gaattactta gcagaatata ttttagataa aacaacactt gaatttctga
    55561 aaaataatag gcaatacaaa attctagatc cttcttgtgg atcaggagta tttttagtaa
    55621 atagttttag acgtattatt gatatgaatt tgggtgataa acttttttgt gaagatgata
    55681 aacttttaaa agaactttta ttatctaata tttatggaat tgatatcaat gaagatgcta
    55741 tcgatgttac tattttctcg ttatatctaa ctattttaga ttacaaagac cctaagatat
    55801 tatcagaatt taaactgcct aatttaaaag ggtgtaattt aatagcgagt gatttttttg
    55861 atgataataa attggagagt ttaaagaaaa ttaactttga ttttatcatt ggaaatccgc
    55921 cttggggaag tgtctcagat ggattacatt tagattattg caataaaaat ggctataatg
    55981 atatgcaaca aaacaaagaa atcagtagaa gttttatttt tagagcaaaa gattttagct
    56041 ctagaaatac agtatgttct tttgtagtgc attctaaaat actatatact caaaaaaagc
    56101 catcaaaaaa attccgtgaa tttttgctta aaaaaagtca aatatttagt gtagttgaaa
    56161 tgtcatctgt aagaaaatta gtgtttaaaa atgcagacgc tcctgcagca gttatatcat
    56221 ttaagtataa cgaaagtgaa gaaaatttaa ataatagaat catctataca tctttaaaac
    56281 caaatgtatt ttttaaatta tttaacatta ttgtaattga aaaatatgat gttaaatata
    56341 tttcacaaaa actattattg gagaatgatt gggcttggaa aactattgtg tatggattca
    56401 gtaaagatat agatataatt atgaatatca aaaaaaaata tcaaactgta aatgaaatta
    56461 ttttgaaaaa cagttttgtt catggaacag ggatacaaat caatggtaat gaaagccatg
    56521 atgcgacaca tttaaaagga aagtggtatg ttgattcaaa gaaaggaata gattcattct
    56581 atgttgatat aaataaaggg aaagaactta ctcaagataa aatgagaaga cctaaggcta
    56641 atcagcaaga aatatttatt cctccatatg tattattaaa aaagggagtt gacacgaaaa
    56701 catatagata tagagcagca ttttcaaatg atgcatttgt atattcagat gcagttacag
    56761 gaatatgtgg aaaaaaagat aatttaacta cactttattg cttgactggt atgcttaact
    56821 cttcttttta ctcatactta aatataatgc taggtacatc aattggaata gaaagagaac
    56881 aaggattttc aacggaaatt tttacgtatc cagcaataga aagtgatgaa attgctaatc
    56941 tggtagtaaa aatacaagaa gcgactaaat tagaaaaaac aactatgttc ttgaatgaaa
    57001 aaaatagttg taagtatatc aaacaattag ataagttaat tttgaagtct tttaatttaa
    57061 atgatgataa atttattgac tatgcaataa atattcaaat tcctgagctt acaaattcta
    57121 agtcaactaa catatataga aaaataacta aggaagattt aattaattat agtgaatgtt
    57181 tcaaagaaca gttttcatcg atatatcgta gggttgggaa aagtatttca atttcggtat
    57241 atccaaaaat attaaatcgt tttacagtat ttgaactaga agtaacagat gaaaaaacag
    57301 atagagagat tatggttaaa gcagaagctg ataataatat ggagttgttt acgaaaataa
    57361 ttagatatga ttataatgat gtttttcatc aaattagaga tattattcat tttggagaaa
    57421 attcatttta tatcataaag cctaattgct ataaatattg gcatcctgct atcgcagaaa
    57481 tggatcttgc tgatgttttg gatcagattt tatctgatac agggggtgaa gaataatggg
    57541 aggatttaaa aattcttcac taaactttta tttaaagcaa gggctttatg aaataattat
    57601 agatggatta atagactgtt gtttacttat gagcaaatca tgtattgaac aatctagaaa
    57661 aatattaaat cacgaagaaa agataagaac gcatttagtt gaaaattatt tagaaaatga
    57721 tattgaaaga agaaaaacat ctttatctaa acaacatcta agatttgaag tagaagcaca
    57781 agaaaattat gacaacaaaa atgaatctta tgagggtagg gttgatataa aagttatatc
    57841 taaagacact ttagcggata gaagggctta ttatatcatt gaatgtaaaa ggatagatgg
    57901 taaggaaact ttaaataaaa aatatataac cgaaggtgta caacgattta ttactgagaa
    57961 atattcttcg cattatggca aaaatataat gcttggattt atagtaaaag atataaatat
    58021 ccagagcaat atacaaaaaa ttaattcact gaatcagaac atattatata catatataga
    58081 tacagatatg ttgacagtta gaagtgattc tgaaaataat tatgctgttt gtgaaagtaa
    58141 atataaagta aaatctaaac tactattgtt aaatcatatt ttttataact tttcgagtat
    58201 aataagataa tcttatgaat ataaaatatt actatgttaa aattatagtt tggttttgat
    58261 aatattataa aaataagttt aagaataaaa tataaaggaa aaaaggggcg tagcactatt
    58321 ttttagtgtg acagcccctt taattttaaa atcggtaagg aggagtgtat ttgaaaaaaa
    58381 ttaagtcata tacagggatt ttgaatgtgg agaaggttat atatgcaata aatgattttc
    58441 agcttccatt tccagttact tttacgcaga tgacatggtt tgtattaaca ctttttataa
    58501 ttatattatt tggtaagtta cctccattat ttatgataga aggagcattt ttaaagtatc
    58561 ttggcatacc aatttttata acttagttta tgtctcaaaa gacttttgat ggaaagaaac
    58621 catatggatt tttaaagtca ataatactat attcattaag acctaaaata acatacgcag
    58681 gaaaaaacat taaatttaaa aataaaatta ttgatgaaaa tataactata gtaaggagtg
    58741 aattatatgt tcccgataaa atatatagag aacaatcttg tatttaataa ggaaggagaa
    58801 tgttttgcat attatgaatt aataccatat aattattcat tcttataagc tgaacaaaaa
    58861 tttattgtac atgataattt taggcaatta atatcacaaa gtagaaatgg taaaattcat
    58921 gcacttcaaa tagccactga aagttctata agagttacac aagaaaggtt aaagaaaaat
    58981 attacaggaa aattaaaaga aattgcttat gaaaaaatag acgagcaaac agaggcactt
    59041 gtttctatga ttggcgataa tcaaattgat tatcgttttt ttattgggtt taagctttta
    59101 gttacagaga aagaaatgaa tataaagagt ataaaaaagt caatattagc taatctatca
    59161 gattttatat atgatgttaa taataaattg atggatgact ttgtcagtat aaataatgat
    59221 gaaattatga gatttttaaa aatggaaaag ttattagaaa ataaaatctc aagaagattt
    59281 aaagttagaa ggttagataa aaatgatttt ggatatttaa ttgaacataa ttatggaaag
    59341 aaaggcacag tttttgaaga ttatcaatac catttaccta caaagaaact taaaagagaa
    59401 acattagtaa agaaatacaa tcttataaag ccaactagat gtcttataga agagaagcaa
    59461 agatacttaa aaattataca tgaggattca gaaagttttg tagcttattt tactattgaa
    59521 attattattg gagaaatgga ttttccatct agtgagatat tctattatca gcaacaacag
    59581 tttgcatttc ctattgatac tagtatgaat gtggaaattg taacaaataa aaaggcttta
    59641 actacagtta gaaataagaa aaaagaatta aaagatttag acaatcatgc ttggcagtca
    59701 gggaatgaaa cagtaacaaa tgtagtagaa gcattagagg ctgtaaatga gcttgtaaat
    59761 aatttaaatc aaacaaaaga atcaatgtat aagttaagct atgtaattag ggtatcagca
    59821 gatagcattg atgaattaaa acgccgttgt gatgaagtta aagattttta tgacgattta
    59881 aatataaaat tagtacgcct aatgggagat atgataggat ttcacaatga atttatacct
    59941 tcaagcaaaa ggtatataaa tgattatatt caatatgtaa ctagtgattt tctagcagga
    60001 ttagggtttg gagcaactca atagcttgga gagaacgaag gaatatatat tggatatagt
    60061 ttagatacag gaagaaatgt ctatcttcaa ccatctcttg caagtcaagg agtaaaagaa
    60121 tctgtaacta atgcgttggt agcagcattc tttggatttt taggaggtgg gaaatcattt
    60181 gctaataact tacttgttta ctattcagta ttgtttggag ggcaagctgt tttggtggat
    60241 ccaaaagctg aacgtggcaa atggaaagaa aatttaccag atatatatca tgaagtaaat
    60301 attgttaatt taacaagtga tatagaaaat aagggaatgc tagatcctta tgtaattatg
    60361 aaagaagtaa aagatagtgg aagtctagct attgatatat taacttttct tacaggaata
    60421 agtagtcatg atggagagca gtttcctata cttagaaaag caatcataaa tgttactcaa
    60481 gacaaatgca gaggactttt gaaggtaata gatgaattaa ggaaagataa ttctcaaata
    60541 tcaaataata ttgcagatca tattgaaagt tttacagatt atgattttgc acaattactt
    60601 ttctcagatg gaaatattaa aggctcaatt aatctagaaa aacaaatgaa tataatacaa
    60661 gttgcagatc ttgttttacc gaataaagat actttatttg aagaatatac aacaatggaa
    60721 agtctttcag tagctatgtt gatagtaatt agtacttttg cattagattt tatccataca
    60781 gatagaagta cttttaaaat agtagattta gatgaagctt ggacatttct taatgtagca
    60841 caaggaaaaa ctttatctaa taaattagtt agagcaggat gtgctatgaa tgcaggagtg
    60901 tattttgtaa ctcaaaatgc aggtgatgta tcagatgaaa atttaaaaaa caatattgga
    60961 ttaaaatttg cattcagaag cacagatatc aatgaaatta agagaatact tgaatttttt
    61021 ggagttgata aggaagatga gaataatcaa aaaaggttaa gagagttaga gaatggacag
    61081 tgtttaatac aagatttata tggacgagtt ggggtaatac aaatacatct agtttttcaa
    61141 gaactcctta ctgcatttga tacaagacca cctataagaa aagaggtgga ttaatgaaat
    61201 cgaaagtatt tagaaattta agctggataa ctattttaat agtagtactt ttactatttt
    61261 ttatttatat aaatttatag atttagagaa acaaatagat acattagata agaaaagaaa
    61321 aaaactcata gatatgagat tagaagatat aattgataaa gaatcatatg aagaaaagta
    61381 tgatgattta acagttgaaa taaagaaact tagtaaagag aaaaaaactc ttaaagcatc
    61441 attaataaat gaaaagagta taaaagcaag acttagagaa tttagaaaga tacttgaaag
    61501 aaatgaattg ttagaaaaat ttgatagata tgtatttgca agtatagtag ataaggttat
    61561 agttggagtt attaatgaag atggtatagt tgatccttat aaaataactt ttgtttataa
    61621 aactagcttt gatgataaac aagatggaca taaatttata aataagagtc cgttagaaac
    61681 gtattcaaaa gataacaacg ataataaaaa gaagtgttca tatactaata atgagacatt
    61741 gcgagactgt agttaaactt attagagaat aacaaggttt cagactttta tattgtgtct
    61801 taaaagtaga tttgccacct atttgccacc ataattattt ttgggtggca aatttattct
    61861 acaatgattt caaaaatatt taccgtctgg tttctcatgt tgttagttac atgtaaatat
    61921 gtatccatag ttgttgaagt tttagcatgt ccgagtatat gctggatatc ttttatatta
    61981 gtaccatttt ctaataacat agtatcaggg tttttaaaat aaagtgtgta ttcttctaaa
    62041 gtagtgataa ttaaaatatc aaatatcact atacaaagga aagtgcacgc tttttatgtt
    62101 taacaaaaac gaaatattaa aaaacttatt gaagaatatg atgtcaaaac aactacagat
    62161 attcaagata tgctaaaaga tttatttaca aatacaattc atcaaatatt tacattgtcg
    62221 aattttagcg gtttaaacat aatatattga ctgatataat aaaatcatag aatattttag
    62281 ggggaaatag attatgttta agaaaaagtt aatagctgtt gcaatgagta taactatgat
    62341 tagtgtaggg agcttttcgt atgctcattc aggaagaact gattcatcag gaggtcatcg
    62401 tgataataaa aataaatctg gattaggaag ttatcactat cattgtggtg gttatccagc
    62461 tcatttacat aataatggtg gttgtcctta tactggagga ggaagcagtt ctggaacaac
    62521 aacttcggtt aataatgaag aaaagcaaaa gaggtctgtt ggagaaaaag gatataatca
    62581 agggtatgaa gatgggtata aaggaaatta tagttcatca aattatagtg gagattatag
    62641 tgatacatat gaatcaaagt actcagaagg atatgaaaaa ggtaaggcta aattagaaga
    62701 ggaagaaaag gtggctaaag agactggata taatttaggg cttacaggtg ctaaatctaa
    62761 taatacatat gaaaaagaag ttttaaaaaa tgcttatgat accggatatt caactggata
    62821 caatgaatat aagactaaaa agatagaaga atataaagct aaagggatag aggatagcaa
    62881 taaagataag gaaaaaatga catttgaaga aaacatagat tctgaattta tagatgctta
    62941 taataatgct tatgacgaaa gacaagaaca attaaaaaat gattacacta ctcaaggatt
    63001 tgagagtgct atcaaaggag aaagatttga cacatcaact ataggtaatg ttaaatatgc
    63061 taattggttt aaagaaggat atgataatgg taaggttaag ttacctaaag caaaagaaag
    63121 tgtatataat caaggttaca atgaagaaga ttttagtata ccagatgaaa tgaagtctat
    63181 tgaaactaag ttaaaaggtg tatatgatga aggtttagaa aaaagagaag aagagaaaag
    63241 tagaaatgct acttatgggg ttggagctgg aacagcagct gtagttgctg gagtagtata
    63301 taagaagaaa aaacgtaaaa agatatagat gctagatata ccaatgatga caagtgtata
    63361 acaaatataa ttttaagtat aaatatttaa aatatagaag ggaaggttat atctatggga
    63421 tttaacttta ggaaaagcat aaatctagga ggaggactca aattaaattt aggtaagaag
    63481 agtgtaggta taagtgctgg tgttaaaggt gctagagtgt cagttaattc aaaaggaaga
    63541 aaatcagcta cattgagtat acctggaact ggaatatcat atacaaaaac tagtacaaag
    63601 aaacgtaaac ctaaataaat atttgatata ctaagaaata gactgttaca aatagtctat
    63661 tttttagtat atagatttaa aaagtgacaa aattttgaaa tataaactaa tttcataaag
    63721 gaaaatatta ttttatgtag aattataata tttaagtaat attataaaat ttataggagg
    63781 atttcattat gaaattaagc aaaatactat tggcaatagg gatgtctgtt tcattattga
    63841 ttgctagttg tccaacatca aacgctctta gttctattaa ttcaataaaa ggtacaaata
    63901 agtatgaaac agcaggttta atagcagata aacaaaatta tgatattgca atacttatta
    63961 attctgaaaa tggattatct gatggattgt cagcaagtgg attgtcagga gctaaaaatg
    64021 ccccaatatt gttaactaag aaagatacaa tcccttcaga aacattaaaa agattagaaa
    64081 aggtaaaaga agtatatcta attggaggaa aaaattcgat aggagcatca gttcagaaaa
    64141 tattaagtga taaaaaaata agcataaata gaataagtgg aactgataga atagatacaa
    64201 gtcataaagt tgcaaaagaa ataggaagag taagtacggt taaaaaagta atattaacta
    64261 atgcttttaa aggcgaacca gatgctatga gtgttgcttc tatagcagtt agagataaat
    64321 ctccaatagt attaactgat ggaaatacta caagttttgc tacagatgga ttagaaactt
    64381 atgcaattgg tggaaaagtc agtatgagtg ataagttaat aaatgaaact aaagcaacaa
    64441 gaataggtgg agtagataga tacgatacaa ataaacaaat aataaataaa ttttataatg
    64501 gctcaaaaga attttacata gcaagtggga ctgatttagt ttattcttta gttggttcta
    64561 caattgcaca aaaaacacct atagtgttag ttggaaatgg aagtaataag agtatattaa
    64621 aaaatgcaag taaaataact gctattggaa atattgatga tgttgttata aaacaatgtt
    64681 taaatataac taataatgtt ggggattcaa atacaggtat tgtaaaagat actaattcaa
    64741 ataatacgaa caaaccaagt aatgagccta gctctaataa tcctggatta actgataaaa
    64801 gtacagtata tgtaactcct aatggaaaat catatcatct aacaaaaaat tgttctacac
    64861 taaaaagaag taaaacaata aataaagtaa cattaaaaca agctaagtca caaggtaaaa
    64921 tagatccttg taatgtttgt gtaaaataat gtattagcca aatatatatt aaaaaagaca
    64981 attaattaag attgtctttt ttattgaaga aatataaatt tatattatgt attattaaaa
    65041 aaaaattatt aattataaaa aataataata aagacgataa gtattaaaat tttatgtttc
    65101 caatatttat gatataatta atatggcaag gaataaatat ttgaaaaagc tatgagtggt
    65161 gtttccatgg aagtttcttc actttcttat gagaggaggt gaaaactatg gaaaatctaa
    65221 tgatgagtat tataactggt gttatagcca gttacattta cgataaatta aagagccact
    65281 ctgagcgacc aactaagagt ggctgggaac ttaatataaa gttccagaaa agtaaatctt
    65341 caaaataatt tgttgaagga aacatcactc aaagttaagt aaaatatgtt tccttgcttt
    65401 tattatatca caaattaaaa atattaacac aaaattttgt gaatatatac ttattattgt
    65461 tctaaaaaaa tatgtaaata attgatttga ttgcatggaa ttattgatgt aatatttaag
    65521 ttaaatatac acaatctcaa ttaaagaaga taagtactat aaattcatat caaaaaaata
    65581 cataaacttt taagttataa ttttataaaa agtcttttag tatcattatt tcaagaggaa
    65641 ttatcatatg aaaaaataac ttcattagaa aagtggataa aaaactggta agaagatgac
    65701 taaagattac atatactatt ac
//
LOCUS       DAEQCW010000010        56497 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.010, whole genome shotgun sequence.
ACCESSION   DAEQCW010000010 DAEQCW010000000
VERSION     DAEQCW010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 56497)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 56497)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..56497
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.010"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..2180
                     /locus_tag="KRO40_000682"
     CDS             <1..2180
                     /locus_tag="KRO40_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH2091518.1"
                     /translation="SAFTKKKMFRFLKITVFVVALSLILLSLLETVAHATGLVDDTIN
                     TENLYSKYPLSNYQLDFYVDNSWAWLPWNWLDGIGKSVQYGLYCITNFVWTISLYLSN
                     ATGYVVQEAYKLDFINDMADSIGQSIQTLAGVTSSGFSTSGFYVGFLLLIILVVGIYV
                     AYTGLIKRETSKALHAVINFVVVFILSASFIAYAPDYIKKINEFSSDISTASLDLGTK
                     IMLPNSDSEGKDSVDLIRDSLFSIQVEQPWLLLQFGNSNAEEIGTDRVEALVSVSPED
                     EDGKTREEIVKTEIEDNDNNILTIPQVVNRLGMVFFLLFFNLGITIFVFLLTGMMLFS
                     QILFIIFAMFLPISFLLSMIPSYESMAKQAIVRVFNTIMTRAGITLIVTVAFSISSMF
                     YNISTDYPFFMVAFLQIVCFAGIYMKLGDLMSMFSLNASDSQSMGRRIFRRPYLFIRH
                     RARRMERRMARAVSAGGISGGVAGALAGSTVSNARTTRNNPTKENRGNTTSIMGQRAG
                     SKIGAVLDTKNKVKDKANAVKENVKDMPTQTAYAVYSAKEKAKSSVSDFKRGMVQEQQ
                     SRQTGRLEKQEQRKKNIANKRMELQKAQEARQARKADGSATTGATRPHERPATASKPS
                     VEKVQEVKRPATTPTSKASEPVKTNVIKERPLSSGASDGKATQSAQPIHRQNIEKVVS
                     QETRQNYVKDRRTKVQQTQSVQKNQQTTEKNHNLVTKKGQKKK"
     gene            2177..3181
                     /locus_tag="KRO40_000683"
     CDS             2177..3181
                     /locus_tag="KRO40_000683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HBH2091519.1"
                     /translation="MKLKHIALIGSLFPILFSIVLFFGVLISADSDDENSNFSSGITG
                     LNLSAEVLKHQPMVEKYAREYGISEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPNS
                     LDTESSIKQGCKYFASLLSSYKNQGINDLNVAIQSYNYGGGYVGYVAGKGKKHTFTLA
                     ESFACEKSGGKKVTYTNTIAVAKNGGWRYGYGNMFYVELVNQYLTVPQVSGELAQKIM
                     NEALKYQGWKYVYGGSNPNTSFDCSGLVQWCYGKAGISLPRTAQAQYDATQHIPLSQA
                     KAGDLVFFHSTYNAGSYVTHVGIYVGNNQMYHAGDPIGYADLNSSYWQQHLIGAGRVK
                     "
     gene            3201..4103
                     /locus_tag="KRO40_000684"
     CDS             3201..4103
                     /locus_tag="KRO40_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008393312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2091520.1"
                     /translation="MFKKSKKQTENVKEKKVRTVKVGTHKKTVIAFWVVLIVSVSFGV
                     YKNFTAIDMHTVHETETIQLRLTDTNGIENFVKNFAKSYYTWNNSKEAIEARTQAISG
                     YLTKELQDLNVDTIRTDIPTSSTVTDVIVWNIEQSGTDTFSATYEVDQQIKEGEQTTA
                     VKAIYTVKVHVDVDGDMVIIQNPTLAPTIEKSDYELKTPEADASVDADTINDATSFLE
                     TFFKLYPIATEKELAYYVSGNVLEPIGKDYLYSELINPVFTKDGDNVKVKVAVKFLDN
                     QTKATQVSQYELVLHKDSNWKIVK"
     gene            4247..4858
                     /locus_tag="KRO40_000685"
     CDS             4247..4858
                     /locus_tag="KRO40_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002591427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091521.1"
                     /translation="MPKGIMLTQEQQEERREEIISVALQLIEKNGFQKTSMRKIAILA
                     NMGKSSLYDFFKTKDEIFVYAVEKEIEETIKKVHRIIADESSPEQCLRKIMLNHLGVP
                     KQYRTVLMWLNTESDYLEEDYRKRLKTARYAYQDIIKSVIENGMESGVFRKTNANLMT
                     RLLINSIISIIYTSRPSASPEKMLDETMDIFLHGIMNDGGELL"
     gene            4855..7422
                     /locus_tag="KRO40_000686"
     CDS             4855..7422
                     /locus_tag="KRO40_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBH2091522.1"
                     /translation="MIYYTLPLLHKQATLEMVGGKGMSLSKLLTTGIPVPEGFHVTTT
                     SYKIFVEKNHIQPYINKLLDGIDTNNTSQLENVSTQIGMLFHNGEMPQEVSDAIKTAY
                     ARLGNIAVAVRSSATAEDLPDASFAGQQETYLNIQGENEVLDAVKRCWASLWTARAIA
                     YRVKNDIKQEIVALAVVVQKLAFSDASGVMFTLNPINGRRSEMIVNAAWGLGESVVSS
                     LVTPDTIVVDKNAERIVSYEVANKEIMTVRNSDGTEEIPTPEQLRKKHALTRNQVMRL
                     TQLGKKIEKYYEMPMDVEWALEKDKLYIVQARPITVLPPEWTLPEKDVIYTRGSLAEH
                     LPNPVTPLFATLGLEIVNRASALLWIDMFGKSAKKLLPENGAYTIINGYVYLSANSKP
                     LLIAVKSLSPRSLRRALTNSVARWETARKEFEDVIKQWEEKPMHMLNAHQIMEGIQTV
                     FYGACIYFTRIQLTLPAASISETLFTKFFQGAARRAGMTDTSVFLLGFDTIALQAEKN
                     LWSLSEWVKQNNTLNLYLQSNPTAKIAENFMSSVPPDEVSLEVWIEWKNRINQYFKEF
                     GRTAYEFDFAYSTPQETLTPTFESIKTFVEGKGESPFLRQSKFEKHRKQAEEEILQHI
                     GSSRKKLFLKLLHWAQETAPMRENAIYCMGMGHPLIRQMFHEISARLIRGGATSHIDD
                     IYWLTKLELEKLIVQLDKNIPLSDRRNSILARKAELKKYQGYMPPAQLPEKKVKSISH
                     APQKQKDGKTVLRGIGTSSGVVTARACVLNSPADFKNFQPGSVLVAVTTTPAWTPLFA
                     SASGIVTDIGGPLSHSSIVARECGIPAVMATHTATRSIKNGQMITVDGSEGTVTIDE"
     gene            7415..8575
                     /locus_tag="KRO40_000687"
     CDS             7415..8575
                     /locus_tag="KRO40_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2091523.1"
                     /translation="MNKKPIFALNLATLVIALGYSLILPVMPFYMENLGAGGRELGWL
                     TAVYALAQTVCAPFWGALSDRIGRKPIISIGIIGYSISLFLFGLASSFWTLFIARSLS
                     GILSSATSVASLAYVGDSSSEEERSKNMSQLGASMSVGVMMGPLLGGILAGYSLALPF
                     FTGAGISFIAFLLILTLLPESIERSGQTEKRKPFDFSDLKSIIFGSAGMVLILIFVVH
                     FCQTGLQGITGLYVVDKFGFSTKQVGVIWMVLAGILIVVQGFLTGPLAKKIGEKRLIL
                     IGMFCKALVAFAMVLTTGFVSVLVVFGLFAVSSAITVPTLNATLSKTDNQHKGTLMGF
                     ASTAGNLSKVIAPLLTGYLYESNIELPYITTGGIALIGVVICYIWIKNQKNK"
     gene            complement(8762..8955)
                     /locus_tag="KRO40_000688"
                     /pseudo
     CDS             complement(8762..8955)
                     /locus_tag="KRO40_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
     gene            9058..9564
                     /locus_tag="KRO40_000689"
     CDS             9058..9564
                     /locus_tag="KRO40_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH2091524.1"
                     /translation="MKNEKKITVALLIVYLLILSWIILFKLQFSFSVLDHIRQINLIP
                     FGGSVIANGKIDFDEIINNAIVFIPVGAYFSLLFKNKSVLKAIGSVLGISFVYEIIQF
                     IFAIGASDITDLISNTLGGIIGIALVYVLSIVLKDKTHKILNRIAIVCTVLVVAFLFM
                     LLAVNNIF"
     gene            9569..9844
                     /locus_tag="KRO40_000690"
     CDS             9569..9844
                     /locus_tag="KRO40_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4865 family protein"
                     /protein_id="HBH2091525.1"
                     /translation="MLITCCFGKDFNLSKFAFEIEHEITPMEQMKAINFSLEKDDCTS
                     KVLIYNPDKWKYVEYYFYKDRPIKKLLEKFIQFCICHNKICFEILNT"
     gene            10114..10686
                     /locus_tag="KRO40_000691"
     CDS             10114..10686
                     /locus_tag="KRO40_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2091526.1"
                     /translation="MNVDTIRTDIPTSSAVTDVIVWNIEQSGTDTLSATYEVDQQIKE
                     REQTTAVKATYTVKVHVDADGDMVIVQNLTLAPAIEKSDYEPKTSETDASVDADTVND
                     ATAFLETFFEVYPTATEKELAYYVSENVIEPIGRDYLYSELVNPVFTKDGDNVKVKVA
                     VKFLDNQTKATQVSQYDLVLHKDSNWKILG"
     gene            10789..11604
                     /locus_tag="KRO40_000692"
     CDS             10789..11604
                     /locus_tag="KRO40_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="effector binding domain-containing protein"
                     /protein_id="HBH2091527.1"
                     /translation="MFKIGEFSKLTQVSTRMLRYYDETGLLKPAKIDSLTGYRMYSAE
                     QISTLNRIIYLRDSGFNVAEIALALNFSNNAIIEQLDRKSIEIMDNIQKEQEKLKKIE
                     IAKKEVLHGKSELYFNITIKEIPSYCVLSLRKEIPNYYYEGELWKELSVFAKENKINI
                     SDETFSIYHNEEYKEKDVDVELCAIVNKIGKATGDFKFRFTEPVSMMACTMVYGDFFN
                     ISYAYRSFAKWLQENSQYKMKGSSRQIVHRGPWNEKNPENYLTEIQIPLENLL"
     gene            11685..12161
                     /locus_tag="KRO40_000693"
     CDS             11685..12161
                     /locus_tag="KRO40_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH2091528.1"
                     /translation="MITYKVNSIGTIYNNEKGAFIQLEAAYIPALRALDGFSHINVLW
                     WFSDFDNTDFRSVLETEQPYKNAPEKMGIFATRSPVRPNPIALSVVEIINIDYMNGMI
                     QIAYIDANDKTPILDIKPYTPSLDRVENPNVPDWCSHWPHSLEESASFAWENEFNF"
     gene            12175..12726
                     /locus_tag="KRO40_000694"
     CDS             12175..12726
                     /locus_tag="KRO40_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091529.1"
                     /translation="MSLQDYIIEKPVIDTEHLILRTMDKNDIDDLKEWISDISLYEYW
                     GKRPSKSEKNPEVLFSKPEKATKSFHWGIVHKQDSKVIGEIWIYLIENNRMAKVAFRL
                     SKQYQGNGLMSEALKSVIEFCFSKTELQKIWTDVHILNHASYKTLEKVGFQREGHIRG
                     GKMVNTYCDYYLYGILKSDYITS"
     gene            complement(13116..14285)
                     /locus_tag="KRO40_000695"
     CDS             complement(13116..14285)
                     /locus_tag="KRO40_000695"
                     /inference="COORDINATES: protein motif:HMM:NF033542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
                     /protein_id="HBH2091530.1"
                     /translation="MFYIGIDVGKFNHCACVISSEGEVLIEPFFFTNNLDGFDSFIKA
                     VKKFKSPRHIVGLEATGHYGDNLINFLITHDYEVALINPLTTDAKRKSKIRKTKNDKK
                     DTFLICSVLFDRDYTRVTQRKLDMKQARELTRYHASIAEDINQKKNQLQKCIDIVIPE
                     FNTWFKTKYSKAYMAVLKEFGSSYNLASANLAHLKKVLKPKSSGSRVNIDASSLRSSA
                     KKSIGENNEAVTLEIKMLIENIELLASQLKTVDKKIEELAVKLDSPIFSIPGIGIYTG
                     MSILSEIGDIHNFSSAVKVMGFAGVDPGTYQSGEYSAPRTALSKRGSRYLRKSLYQCI
                     LTVCKYNLTFNKYYKLKRLQGKSHRCAQGHSVRKLIRVIYKLLSENIQFDEKLLI"
     gene            14564..15475
                     /locus_tag="KRO40_000696"
     CDS             14564..15475
                     /locus_tag="KRO40_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2091531.1"
                     /translation="MYAYENIEMSLNYIEQHLSEKIETEKLAEIACLSTFYYQRLFKK
                     LVKKSVQEYIKLRRLAMVIAELNNSEERILDIALKYGFSDHANFTRAFKEVYHITPDE
                     YRKNVPMLNTFDKPELSSRYIMIDENVPLIVGNIVLEIQRKTLRTKETYFGFEKTVNI
                     AEQIPAGESTGIDVPGQLWREFHAKKLQTENAIFNNDIELGVSHLASPDKGTFLYFAG
                     GMVSSTDVCPKNMVQHTLPAGEYIVCKIEAESFEELVTTALNQANKYLFETWLPNHNL
                     VTKPFMAEKYYKGNAEINYMEVWIIPV"
     gene            15553..15987
                     /locus_tag="KRO40_000697"
     CDS             15553..15987
                     /locus_tag="KRO40_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH2091532.1"
                     /translation="MINIKDINYVPNISEISVYIENSAFDELYQHMNNEYKAVCKIEY
                     SKDVWARGWNVKFKKSGKSLCVVYPKKNYFTVLVVVGNKEKEDVENLLPRLSEYVQEI
                     YRNTREGNGQRWLMIDLKSKNNVYQDVLRLIEIRYAIKCVKP"
     gene            16455..17195
                     /locus_tag="KRO40_000698"
                     /pseudo
     CDS             16455..17195
                     /locus_tag="KRO40_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
     gene            17146..17757
                     /locus_tag="KRO40_000699"
                     /pseudo
     CDS             17146..17757
                     /locus_tag="KRO40_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860758.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
     gene            17970..18827
                     /locus_tag="KRO40_000700"
     CDS             17970..18827
                     /locus_tag="KRO40_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002585362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2091533.1"
                     /translation="MYKEVGISSNNVPITLSIWYTERSSPTIVFLPGTMSHPLMYENF
                     LCGLSERGFNIIGIHYLSHGKSPKIKKNYTMEDLLHNVYDATTYGIENFGENIAVMGS
                     SQGGILAAMAAGRDTRLKAVFPHNIMLTTLKETMSLTKYPTWSHRFMGLIQWGFRVGG
                     KLLPNYKVPGDAYLDYDRVFYSEQAKQDCLNDPMLLPYYPLRFVASLFNADLSCLENG
                     AIQCPVILITAKGDPLFSFDYTNKVFDLIHVPQKELLALELNRHMIFNEDTDTTINAL
                     EATLHKYLG"
     gene            18905..19486
                     /locus_tag="KRO40_000701"
     CDS             18905..19486
                     /locus_tag="KRO40_000701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091534.1"
                     /translation="MPRFTEQEKEIINSKLLIEGEKLFALHGLKKVTVDDLVAAVNIS
                     KGSFYAFYPSKEHLYVEINFRLQKELFTSIETTIKKKKYKNHRDLAKDVIMLSLTGVI
                     TSPILSQIDLSLMDYLQRKISSDIFENHMYSDIRILEILEDLGVVFLVPHTVIIKSLY
                     SVLSCLEQFKEDEELNMIQNLLVNGIIQQVVAE"
     gene            19590..20435
                     /locus_tag="KRO40_000702"
     CDS             19590..20435
                     /locus_tag="KRO40_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091535.1"
                     /translation="MIDVKKLYFSYTDKPFVENVSFHVGRGEIFGFLGPSGAGKSTIQ
                     KVLTGLNTRYKGSVKVAGTEIREHTNQFYENIGVDFEFSTCYEKFTARQNLAYFASLY
                     EKQPRSIDELLHMVGLENDGDKKVADFSKGMRSRLNFIKALVHDPDILFLDEPTSGLD
                     PTNSRLMKDIILAEKKRGKTIIITTHNMFDATELCDQVAFIVAGKVSALDSPHNLIMS
                     RGAAKIQYTYYDKGEKTGECLLDRTTEDKLLKSLISENRLLSIHSSEPTLNDIFVDIT
                     GRTLQ"
     gene            20432..21115
                     /locus_tag="KRO40_000703"
     CDS             20432..21115
                     /locus_tag="KRO40_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016295773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091536.1"
                     /translation="MRLGRLICGDIHFQWKYGFYFIYFILTVLYVCGIAALPEHWKTD
                     IASIMIYSDPAAMGLFFMGAIVLLEKSQKVLNAMVVSPVKVSEYILSKTIALIAISTV
                     IALILGVVSDSNHLLGITVGTALTSAIFTMLGIIAATKISNLNQFLIVIMPIEIVCFV
                     PPIVGLFVKLPYLFRFFPFTACMNLITGKSVLLSFDMVLVIATLIILYIVARHTVKHM
                     WKSLGGVKL"
     gene            21112..21810
                     /locus_tag="KRO40_000704"
     CDS             21112..21810
                     /locus_tag="KRO40_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002583502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091537.1"
                     /translation="MKRILSSTIQVFRQIKSDPMMFAACFTPFVMGALIKLGIPFLER
                     ITDFSLQAYYPIFDLLLSIMAPVLLCFAFAMITLEEIDDKVSRYFSITPLGKSGYLFT
                     RLGVPSIISAVIAFIVLLLFSLEKLSIGMTICLALLGSVQAIIVSLMIITLSSNKLEG
                     MAVTKLAALTLLGIPAPFFIDSYYQFAVGFLPSFWVAKAMQNEAVLYFSIGLVVALVW
                     YYFLTKRLFRKLAG"
     gene            21822..22733
                     /locus_tag="KRO40_000705"
     CDS             21822..22733
                     /locus_tag="KRO40_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH2091538.1"
                     /translation="MEKGRLLQNGKVNRAIQVSKITLFINLSLSLLKFTAGYIGKSSA
                     MLSDAVHSASDVLSTIVVMVGIKISEKQPDREHPYGHERMECAASIILSVALAITGAG
                     IGYSGIKKIFSEQYNTLSTPSGIALTAAVLSIVIKEWMYWFTRNAAKHTNSDALMADA
                     WHHRSDALSSVGSLIGILGARLGYAILDPIASVVICGCILKAALDIFKESINKMVDHS
                     CDNATETKIREVVLQQQGVDGIDELKTRMFGAKMYVDIEILADGNLALYDAHRIAEGV
                     HQTIENNFPQCKHCMVHVNTNELLYSA"
     gene            22785..22925
                     /locus_tag="KRO40_000706"
     CDS             22785..22925
                     /locus_tag="KRO40_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016295776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091539.1"
                     /translation="MEQYWWIIIVVVLIVVGLLKIVIMKKYNQRRNSNNSPKDSEDDK
                     MY"
     gene            23215..23841
                     /locus_tag="KRO40_000707"
     CDS             23215..23841
                     /locus_tag="KRO40_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091540.1"
                     /translation="MSDTKENILKIALHLFAVNGYEAVSVSMIAEALGMTKGALYKHY
                     KNKQDIFDCIVERMYQIDNKRAKDYQVPESTIEVTPNAYRNTTIGSLITFTLAQYDFW
                     VTDEFASNFRKMLILEQYRNLKVNMLYQKCLVNGPISYIEDIFNEMIEKGVLQECDTK
                     QLAIEYYAPLFLLISVADAVENCWDLKTQLTTHVKQFVKKYIINEKVK"
     gene            23963..24679
                     /locus_tag="KRO40_000708"
     CDS             23963..24679
                     /locus_tag="KRO40_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH2091541.1"
                     /translation="MEYIRSKKYFTPDLQTKIMGPNPIKLQEELLQNHKIPSGSYVCD
                     LGSGQGLTSVFLAKEYGFVVFAVDLWSEPKENEEFFKKMGLSSAQIKSVKADANELKF
                     EKEFFDAVVSTDSYNYFGRDPIYLDEKLLPFVKKGGFVYITVPGMKKDCHEKLPEELL
                     LSWTPEELDYIHDITYWSNIISHCKKADLISIYEMESNSEVWSDWIKQNNEYAINDRK
                     AIEAGGGDYLNFIAIILQKK"
     gene            24843..25034
                     /locus_tag="KRO40_000709"
     CDS             24843..25034
                     /locus_tag="KRO40_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003064779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4177 domain-containing protein"
                     /protein_id="HBH2091542.1"
                     /translation="MKKYEYVEINYNAKGVVFLCTDKHKEIIDSYAKTGYHYAGFVPT
                     EIDAKGCMRKIDLIFEKED"
     gene            25058..25288
                     /locus_tag="KRO40_000710"
     CDS             25058..25288
                     /locus_tag="KRO40_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091543.1"
                     /translation="MIGLKRRNMNYIMKVGAKAQGVSVSEFRAMLQDTIDKTMESTDP
                     DVQANFKRYFGNKRPTPEEYIYTITKKTKVKV"
     gene            25555..25974
                     /locus_tag="KRO40_000711"
     CDS             25555..25974
                     /locus_tag="KRO40_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009261829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2091544.1"
                     /translation="MKPSDFQKTIQCQFECKLKKVVKGIIWNYRKELKRRKNKEISFS
                     ELPDITVESLATWDDYETNYTIFNVCGIDIKVLDDELAEALKQLPEKKRNNVLMYYFL
                     EMSDTEIADIMNYTRGAVFKHRHRALETMKEILKEKK"
     gene            25977..26231
                     /locus_tag="KRO40_000712"
     CDS             25977..26231
                     /locus_tag="KRO40_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091545.1"
                     /translation="MKKKYKHPSYYLISSAMDGDETAIEKLLVFYDPYISKCCLRPLY
                     DEYGNVYIVVDMELKGRIREALIKMILDFEIDIDIETEEE"
     gene            26603..26806
                     /locus_tag="KRO40_000713"
     CDS             26603..26806
                     /locus_tag="KRO40_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH2091546.1"
                     /translation="MNNTDVPIWEKYTLSIEEASRYFRIGEKKLRRLAEENLDSGWVI
                     VNGNRIQIKRKQFEKIIDTLDEI"
     gene            26884..28074
                     /locus_tag="KRO40_000714"
     CDS             26884..28074
                     /locus_tag="KRO40_000714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006354938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH2091547.1"
                     /translation="MSKVKRQDSKGRNLRLGESQRKDGRYVYKYTDIFGKPQFVYAWK
                     LVPTDKTPAGKRDDISLREKEKQIKKDLDDGIDTVGGKMTVCQLYEKKNNQRKNIKRN
                     TKIGRQYLMNALENDPLGMRAIDTVKQSDAKEWAIRMNDKGYSYKTIDNYKRSLKASF
                     YMAIQDDCIRKNPFNFKLSDVLEDDTEAKVILTPEQEEKLLAFMETDNVYSKYRDEVI
                     LLLETGLRISELCGLTTHIDMLNRVININHQLLRDTEVGYYISTPKTKNGKRKLPLTE
                     RAYQALERILKNRGKAQPLVVDGYSNFLFLNREGLPKVAGNYESMVRGLIKKYNKTHK
                     DKLPNITPHSFRHTYCTNMANKGMNPNTLQYIMGHANITMTLGYYAHGTFQSAKAELE
                     RLAS"
     gene            28314..29135
                     /locus_tag="KRO40_000715"
     CDS             28314..29135
                     /locus_tag="KRO40_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MoxR family ATPase"
                     /protein_id="HBH2091548.1"
                     /translation="MIKKEISNFRGSSDYVVSPELMASVNVAIALEKPLLIKGEPGTG
                     KTMLAQAISNELKKDLVIWNIKSTTKAQEGLYVYDTVQRLYDSQFGGEGVDDISKYIK
                     YGKLGEAFSSNQQVILLIDEIDKADLEFPNDLLWELDKMEFYINETKETVRAKQRPIV
                     IITSNAEKELPDAFLRRCIFHYIEFPDRDMMEEIVKVHFDKVEEHLLEQVMTTFYWIR
                     SLKDIQKKPSTSELIDWIQALTLSGMPIEKIEKEVPFAGILLKNNEDIESMQRHL"
     gene            29156..30352
                     /locus_tag="KRO40_000716"
     CDS             29156..30352
                     /locus_tag="KRO40_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VWA domain-containing protein"
                     /protein_id="HBH2091549.1"
                     /translation="MFIEFFYLLRSRGLNVSLNEWMTLIEALDKGLCYSNFSNFYYLC
                     RMILIKSESDFDKFDAVFLEYFKGIEHQEEIPEEIMNWLKKPDIDLEEFERLEQNPNI
                     NLDKLRAKLEERIKEQDSPHNGGNYWIGTGGTSELGHSGKGQTGIRIGGNSTYGRAVL
                     EVAGERKYRDFRDDEVLNMRQFQVALKRLRQFSTRIDAPKTELDLDKTIEETCNNAGY
                     LKLFFEKPRKNTVKLLLLMDSGGSMRGYSTLCNTLFQSVSKSNHFKDVKIYYFHNCIY
                     DRLFTTPECWLSKSINTEWILKNIDKNYKVIIVGDASMSPSELLHIGGNYRGPYNYTP
                     GIEWLKRFKRKYSKIVWMNPELRDGWDSINYWYQTQRMIQSEFNMFPLTVKGLEKALK
                     NLMVSR"
     gene            30520..33918
                     /locus_tag="KRO40_000717"
     CDS             30520..33918
                     /locus_tag="KRO40_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBH2091550.1"
                     /translation="MIIINYELIVKYNGDILRLEEELGVSVEILNSSYAIITSSNEED
                     VNILLTYPEIEFIEKPFILQTQDVQSFSSTGITGFKNRTGLTGKGTIIGIIDSGIDYT
                     LPVFRDSDGRSKILYYWDQSIQGNPPEGFREGTLYTNEDINNAIDGSMYIPISTTSLH
                     GTHVAGICATIASDARIIVVRVGNIQTDIFSRSTEFMRAIKFILDRALELRMPVTLNI
                     SYGSNEGSHRGTSLFEQYIDDMCLFWKNNIVVAAGNNADKGGHKRIRLQNNITEEVEF
                     IVGEGERILNINIWPDFVDDFSVHLVNPSNNQTQAISLTSGEIRNTLGETRITGYFYP
                     IAPYSLTRRVTLQLSSNTQITPGLWKIVFEPIDIVTGNVNIYLPTSEGLNRNTRFLIP
                     TQELTVTVPGTASRVITVGSFNSRTDIVSIFSGEGDTQLGVFKPDLLAPGEDIVSFLP
                     GGTSGALTGTSMATPHVTGVCSLFMEWGIVNGNDLFLYSQKLRALLLKGARRLSNQSY
                     PNNSSGFGFLNLSDIDLYTLSNINQDLETEDIGYRSINKSFKDEENSYKFIDGYNMQI
                     HNDLENEIYISKNASRQSGILSGIDIVHTPEFEEELAGLGMSQRFFKISDSLGVLSIN
                     NTDYNSIQRVLQLPSIIRTVSTTKMTLLGEINRGTFGGVVATEEMGVNFFKNNPNINI
                     TGRGTLISIADTGIDYLHPDFIYPDGTSKIVYLWDQTKEGTPPDGFYIGTEYTREDIN
                     RAIAENDPSLSQDEVGQGTMLSGICAGLGNVNSEYAGIAEDSELIIIKLGKIDDFYNS
                     AMLFAASQYAYKKAFELGRPLVINMSLGTSSLAGLTNRSNSEKAFFTRGLCITAGAGN
                     EGNTQTHTSGIIPYVGGSVEVELELNEDEEELSLELWLNRPDKADVIIVSPTGEESKS
                     VGISNYNKVTGLFDLEGTEYSITYIYPTTFSGQQFTNVTLKNAKRGVWKIRLVGVYII
                     TGRYNLYLPNRELLKSGTRFREVDPFYTINYPAIQDDLITIGAYNTINGSLWQSSSRG
                     PTIEDRLKPDIVAPGVNIIAAYPGNTYATITGTAAASAHAAGAAAMYFQYTFVDGRYP
                     NQAYVQKIKTFMQAGARKDSNTVYPNTNSGYGLLDVRGMFDVLR"
     gene            33928..35601
                     /locus_tag="KRO40_000718"
     CDS             33928..35601
                     /locus_tag="KRO40_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBH2091551.1"
                     /translation="MEKSYCIIYQGDIESALQENGINRYMVLNSQLAVIYVPLDFDET
                     ILNNIIQVAWWEESEPMSSLIEITNNVNNGETITTAAETDYIYENPYNDITGRGILLA
                     VIDSGIDYLHPDFINDDGTSKVLYLWDQEANTNPPPEGFIFGSEFTRSELNIAINRND
                     GSLSQDNIGTGTLVSGILVGNGRINSQYRGITTESDLIVVKLKSYTDTYYAGRINYSV
                     SDFLAAITYVTNIARTENKPLIINLTIGVKSSAVATTSILDTFNILSSAGVVVVSGAG
                     NQGNTDIHYSGRFSSVGEVQDVIIQDGDDYALDITLNTNGPDKVGAQIISPSGEVSHD
                     IRYSPDFYIYRGKFNLENTTYAMRFIYPYITSGKENLEIRLRDIKPGVWILRLTSELI
                     INGEYDIYLPNKNLIAPDTRFLDPDSVATITMYAASDDVITVGTFNNKTDSMWIGSSK
                     GPIRGRGIKPDIVASGVDIISTYKNGTYNTGTGTGVSSSIVTGVLALLMEYLEKQDNV
                     PRLSLFTQVLKTYLILGATKLEIYTYPNVSQGYGILNLKNTIQQIANTL"
     gene            35874..36068
                     /locus_tag="KRO40_000719"
     CDS             35874..36068
                     /locus_tag="KRO40_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3787 domain-containing protein"
                     /protein_id="HBH2091552.1"
                     /translation="MESKKARALKGKDNKRLKSSLLVGNESTAAWADVEKLKPHSKVS
                     IPSIKGVEEAKDWVDNGSKL"
     misc_binding    36237..36470
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            36547..37944
                     /gene="asnS"
                     /locus_tag="KRO40_000720"
     CDS             36547..37944
                     /gene="asnS"
                     /locus_tag="KRO40_000720"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HBH2091553.1"
                     /translation="MQKEFITVKELYREKEQYIGKTVKVAGWIRTSRVSKNFGFIELN
                     DGSFFKNMQIVFDEKVENFKEVGKLAISSSILVEGELVSTEGAKQPVEIHAKSIVVEG
                     ESDSSYPLQKKRHTLEYLRTIAHLRPRSNTFSAVFRVRSIAAYAIHKFFQERNFVYAH
                     SPIITGSDCEGAGEMFRITTMDLNDIPKTEDGKIDYTQDFFGKEANLTVSGQLNAEIM
                     ALSFRNVYTFGPTFRAENSYTGRHASEFWMIEPEIVFADLEDNMELAEDMIKYVISYV
                     LENAPEEMEFFNSFIDKGLLERLNKIVNSEFIRITYTKAVELLIESGHEFEYPVEWGC
                     DLQTEHERYITEQIYNCPVFVTDYPKDIKAFYMRMNEDGKTVRAMDLLVPGVGEIVGG
                     SQREEREDVLLDRINEMGLREEDYWWYLELRKFGTATHSGFGLGFERIIMYMTGMSNI
                     RDVIPFPRTPKNAEF"
     gene            complement(38117..39292)
                     /locus_tag="KRO40_000721"
     CDS             complement(38117..39292)
                     /locus_tag="KRO40_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2091554.1"
                     /translation="MNLEKIKKFFGFPLDKKHKDNVEKELCNYLYHTGKIICIIIVIS
                     QIIMMISISAREGGPFVTPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCCTFYIN
                     LWIIYVTFFCLWGCVITLLDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLF
                     LNLFLPGIQTIPGNEFSNIVNTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEIS
                     HINNLLNDKVMTDDLTKMNNRRYLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNY
                     GHQKGDYCLQNIAKVILDFTSSENEHAIRYGGEEFFICIFNCNEADAKLKSECLRKII
                     ESCNFERDDVPLKCVTVSIGVYTKKIGKTITLNEFISNCDKALYTAKEQGRNCVAFY"
     gene            39711..41075
                     /locus_tag="KRO40_000722"
     CDS             39711..41075
                     /locus_tag="KRO40_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH2091555.1"
                     /translation="MGEKKINNMNYSHNNYSKKTGEPTRKIKNSHITLKSKEEKICSS
                     CNKENNTKDNYCKFCGNELYEIASLRPLETKLDLKSKIKELSYHANKRGVFLTTFTTI
                     FILFIIALIFKAIITIQFNDISYLVNPAHIILALNLGQISVSMSTMMGSGFINANIGL
                     LILLIIPILVLLISNLIFMRKRCRDSKTVLANSLGVGIFYGLVLAILSIFTNVKTSSH
                     SMLEYGYALEYSYEFFSVLLNGFVLGFICTYITTYKKSYEKENMYLSLFSNSIRTFIL
                     GYVLVLVILLVLTISDSSYLNELDMSSYSNGLNLFTILPQIASYMWAFANGISVTIIN
                     STVSMFTLSSSSLFGDTKLMFYAMGALSMLILLLNGYKLRFKYNTDSIRPIIVFSIYY
                     AFLMGILALFSTFILDSNINFFNTTNYGTTLIMQFKVLQAIVISFVYSFVISLIGYKL
                     NSAD"
     gene            41097..41588
                     /locus_tag="KRO40_000723"
     CDS             41097..41588
                     /locus_tag="KRO40_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH2091556.1"
                     /translation="MEGNTNNKVDDKFSKVKKKFGSGKFKVELYKEKSKLNREIDDIQ
                     EEKAKIFLEMGILTYQKIREDSINDNSFDKLCDELLELDKLIYEKNMEINEMEMAESN
                     VTCECGYVGNVNDKYCAECGKKFELENECDDFIICGYCESEIDTEAEFCPCCGRKIII
                     DLE"
     gene            41861..42532
                     /locus_tag="KRO40_000724"
     CDS             41861..42532
                     /locus_tag="KRO40_000724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HBH2091557.1"
                     /translation="MLDKVKGRLIVSCQALEDEPLHSPFIMGRMAKAAMEGGAVGIRA
                     QGVEDIIEIKKVTGLPVIGIIKRNYEDSDIYITPTKKEVDELLTTGCEMIALDATNRV
                     RPNNEDLKELIKYIKENGVLVMADISNYDEAIKAQEYGVDCVSTTLSGYTPYTKTLEG
                     PDFVLMERLVKDLEIPVIAEGKVNTPQDLKKVFELGVHSSVVGSAITRPQLITEKFVK
                     AIEIN"
     gene            42617..43483
                     /locus_tag="KRO40_000725"
     CDS             42617..43483
                     /locus_tag="KRO40_000725"
                     /EC_number="4.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HBH2091558.1"
                     /translation="MKGIYSALLVSFDKEGNINEKGLRQIIRHNIDVCKVDGLYVGGS
                     TGENFMLSTDEKKRIFEIAKDEVKEEIKLIAQVGSVNLKEAVELAKFTTDLGYDAISA
                     VTPFYYKFDFEEIKHYYNTIINSVDNRLIIYSIPFLTGVDMSLDQFGELFENEKIIGV
                     KFTAADFYLLERMRKTFPNKLIFAGFDEMMLPATVLGVDGAIGSTFNVNGVRARQIFE
                     LTKNEKISEALEVQHVTNDLITDILGNGLYQTIKLLLEEQGVEAGYCRQPMKEATDEM
                     KSRAKEIYRKYF"
     gene            43516..45018
                     /locus_tag="KRO40_000726"
     CDS             43516..45018
                     /locus_tag="KRO40_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBH2091559.1"
                     /translation="MVGFTWIDFAILVVYLLAVLFAGLLFSKKEMKGKEFFKGDGTIP
                     WWVTSVSIFATLLSPISFLSLAGNSYGGTWILWFAQLGMFIAIPLTIKFFLPLYSRLE
                     IDTAYEYLEMRYESKGLRVLGALMFIIYQIGRMSIIMYLPSIVLAGLTGIPVNVLIIV
                     MGVIAIIYSYTGGLKAVLWTDFIQGMVLIVGVTGTLFYLIASINGGFGTVMDTLTTGH
                     KFLASNEVMFDKNILSTSAFIIFVGAGLNTFSSYVSSQDIVQRFTTTTDIKQLNKMTY
                     GNGVLSMGLATVFYLIGTCLFIYYTQNPDLAQTVQQDQVFASYIAYELPVGITGILLA
                     AIYAASQSTLSTGLNSVATSWTLDIQTIITKDISMEKQTKIAQYISLGVGILSIAVAI
                     VLANGEIKSAYEWFNSFMGLVLGVLAGIFVLGAFCKKATKMGAYVGFIVSAILVVYLK
                     YRMPEVTSWAYSLITITTSVVVGTIVSAIEAKVKAKVSLPKAETTVYYEK"
     gene            45148..45600
                     /locus_tag="KRO40_000727"
     CDS             45148..45600
                     /locus_tag="KRO40_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HBH2091560.1"
                     /translation="MIFGNINHSKTYSTLHEDLLRCFEYAKDNSLIDYEKGTYTIDGD
                     DIFVNIVEYKTCEKEDRFWEAHKKYIDVHLMLDGCERIDINFIENLEQKIYEEKGDFL
                     PLDGKNNGYMELRKGDFLVCYPEDAHMTGIKVLEKENIKKAIFKVLVR"
     gene            45760..46563
                     /locus_tag="KRO40_000728"
     CDS             45760..46563
                     /locus_tag="KRO40_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091561.1"
                     /translation="MENIDVFLLIGQSNARGLGNPKESIIPNENCFEYLSTDEIINMR
                     CELETSEGDGTIAPAFSNEWNKLTGNKVCFIHNAKDGSRIKNWNHDNNWFLNDTIEKF
                     NTGCTTLSKHYNIENKYVIWIQGESDAKYGSDVLYYKESLKKIAYRLKEECMIDKMFV
                     SLTGYWLGEDEYFIRTRRIAAAQESACSECDILCVGSKIAMQFHDRGLTIDDVHYTQE
                     GLNMLGEDLCKNIYKYHITKEKSVLSDTIDLSEARKYICELEKISKRFV"
     gene            46621..47508
                     /locus_tag="KRO40_000729"
     CDS             46621..47508
                     /locus_tag="KRO40_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH2091562.1"
                     /translation="MKNYVCIDVGGTSIKYGFIREDGFIIDKSSLDTEAKEKGGEGIL
                     AKIKDIVKKYIEENEISGICISTAGMVDPVEGKILFALEELIPNYKGMQLKKEVEKEF
                     NIKCEVENDVNCAGLGEMWLGAGRGATSSICLTIGTGIGGCIIINNKLINGFSNSAGE
                     VGYMNVNGSSFQELASTSSLIKKVAKIKNLNENDLNGKIIFDLAKNNDEDCLKELDNM
                     IKSLAVGIANICYVINPEVVILGGGIMAQEKFLKPKIDKALKEVLIERVYKNTNIEFA
                     KRQNDAGMLGALYNFLNKI"
     gene            47527..48375
                     /locus_tag="KRO40_000730"
     CDS             47527..48375
                     /locus_tag="KRO40_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2091563.1"
                     /translation="MSILEQLESPTFKVTKSDKLLIAYIKENIDDVFYKPISQIAKES
                     NIGEATITRFVKKMNFNGLQDFKVTLAQEISTINKKNIINKNIQNDEPALDTAKKLLS
                     SNVTTLENTVEIINSKDVHDCARLIINAKKVYFIGIGYSGIIAQDSNYKFMRIGLNCV
                     SFDSSHTMIMMSSIMEEGDLIIAISHSGETEEIIKTVKLARANNAKIISITENKNSEL
                     KDISDVHLSYVSGETVLETGSISSKLAQFFIIDLVYTQVVKELSNEAIERKIKTTNAI
                     KLFKNE"
     gene            48438..49127
                     /locus_tag="KRO40_000731"
     CDS             48438..49127
                     /locus_tag="KRO40_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH2091564.1"
                     /translation="MSKLKDYNIDKVIIFNNLSTKTKNQLKEKVKLKRLQKKEILFYE
                     KDSLDSVYILLEGKVSIFKISENGERKVIFILNSGEVINDITLDASKNSTVGCEAFEN
                     SIVAYYSIEEFLEIMQNDFQLTKDIISYMERRIRRLYRQLKNSISIKVDKKLAAKLYR
                     LSREFGVCCGEWTLLNVNITVTYLADMLGCKRETVSRMIKVLQKEELIKIDNKGFYVK
                     ETELSRYFKNN"
     gene            49518..50525
                     /gene="asrA"
                     /locus_tag="KRO40_000732"
     CDS             49518..50525
                     /gene="asrA"
                     /locus_tag="KRO40_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrA"
                     /protein_id="HBH2091565.1"
                     /translation="MKLKLDSSKFNEGLNYLKKDYKIFAPVLIPFKGTFSDTDVIRYK
                     EVNAFEEMEFAKKANFSPKEVVLPINQVLFYFTEKEFKESDLDNKKILIFLRACDING
                     IKRLDEIYLNNGEEKDYFYKNIRDKVKFALVGCKESFRNCFCVSMDSNKTDNYSIGLN
                     IEGDTLYLDIKDSEFEVFNGEATEFNVDYVTDNLISVDVPENIDSNEMIGNSIWDEYD
                     TRCIGCGRCNFVCPTCSCFTMQDIFYKENENVGERRRVWASCQVDGYTDIAGGNSFRK
                     KQGERMRFKTMHKIHDFKKRFGYHMCVGCGRCDDACPQYISFSKCIEKINDLVISKEE
                     V"
     gene            50526..51317
                     /gene="asrB"
                     /locus_tag="KRO40_000733"
     CDS             50526..51317
                     /gene="asrB"
                     /locus_tag="KRO40_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrB"
                     /protein_id="HBH2091566.1"
                     /translation="MNPYIPVSAKILDIVKHTDKEWTFRVNCNTKGVLPGKFYEISIP
                     KYGESPISVSGYGEDYIDFTIRNVGKVTSELFNYKEGDSFFIRGPYGNGFDVSLYEGR
                     EIVVVAGGSALAPVRGIVEYFYNNKEKCEKFKLIVGFKSPKDILFADDLKRWSKKLDI
                     LVTVDGAEEGYSGNVGLVTKYIPELDMKDINNTSIVVVGPPMMMKFTVEEFLKRDLDE
                     KNIWVSYERKMCCGIGKCGHCKMDDTYICLDGPVFDYSYAKNLID"
     gene            51330..52301
                     /gene="asrC"
                     /locus_tag="KRO40_000734"
     CDS             51330..52301
                     /gene="asrC"
                     /locus_tag="KRO40_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite reductase subunit C"
                     /protein_id="HBH2091567.1"
                     /translation="MIRDLNTKKVMKNAYRITKTKYETSLRVRVPGGLIDPESLAVVS
                     KIASEYGNGQVHITTRQGFEILGINMEDMEEINKIIQPVIEKMNINQSEKNAGYPAAG
                     TRNIAACIGNKVCPKAQYNTTEFAKRIEKAIFPNDLHFKVALTGCPNDCIKARMNDFG
                     IIGMALPIYEKDRCVNCGACVKKCSKISVGALKTENNKVVRDKDKCIGCGECVLNCPT
                     NAWTRDEKKYYRLAIMGRTGKKNPRLAEDFLLWVDEDSIIKIILNTYRYVEKYIDKDA
                     PGGKEHIGYIIDRTGFMEFKKWALEGVELPEITKMYENIYWSGIKYL"
     gene            52358..53134
                     /locus_tag="KRO40_000735"
     CDS             52358..53134
                     /locus_tag="KRO40_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBH2091568.1"
                     /translation="MHKETLDKLTNAAINKINLLNTSKVKYLVSSAFAGLYVGIGILL
                     IFTIGGLLTDAGSPMTKIVMGLSFAIALSLVIMTGTELFTGNNMVMSAGMLNKGVSIK
                     DTSKIWAYSWVGNLIGALVLGIIFVGTGLVDKGPVAEFFANTAASKASMPFTALFFRG
                     ILCNILVCVSVLCSFRTNSDTAKIIMIFLCLFAFITSGFEHSVANMTIYSVSLFSPTI
                     STVTIGGAIYNLVAVTLGNIVGGALFMGLGTYILGKEKLN"
     gene            53405..55423
                     /locus_tag="KRO40_000736"
     CDS             53405..55423
                     /locus_tag="KRO40_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBH2091569.1"
                     /translation="MTKKLVISKTKLFIFIIAFISIFIYLFGSKNTLIGVGIVTAMLT
                     LLERDLTISPIKNLLKYLAINIILGILSFFAVQNMYLGVLLNFIALFIIGYVFSYDLK
                     RAVYVPFGLMYIFMVSIPVGKSEFPMRLSALAVGAVIIMIAQFVMNRNRMKNVGDKEL
                     ISICDELLEKISLLKNTINDDSSIIKSSMRKIDSCNYRINSISKNLKMVIFDNRKDDF
                     YISIRGIDIMNILFSLERISLILERYKKDSKEFEDEDIKNILEESSINSKSDVLVVAT
                     KEINYIKMCLENKDTITDKEILGFRDYVISQDTKNINLKEIYSVLENLYEFLVDYKKV
                     KSRDEKKAERKSKIPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLR
                     DGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLA
                     GYINSYVVDYRKLMVCVTVSALGSAVVMGDPNVLTISRISYVALGAIIALIVNKFILP
                     YDAKTGYQHVIEMYKGIVKNIIDEVNKSIENVADVYYIKNLLLIPSLIEDRLMLINAI
                     YKDKHQEDFLENQKLLISNMYNLYINVNKNKIKDEDVEKILRDTNYISNYNVDKYDEG
                     RSVILESIVNTKSLGDKIICLNLLQTLNGVKEMYRISNITKVSIKEAA"
     gene            55637..56494
                     /locus_tag="KRO40_000737"
     CDS             55637..56494
                     /locus_tag="KRO40_000737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2091570.1"
                     /translation="MSKDVKVKRNKKYDTFSITMELERPLLYDEVENKDDKNNNRKFN
                     IKNKIFKGIGILFVLILLGFFIWINKTYEPQKLAKEALVSNSKVEVTVNENISFTPKG
                     RKVSKGLILYPGAKVEIESYAPLARKIAESGYEVVIVKMPLNLAILGTNKAQKVMDSY
                     NNIEHWVIGGHSLGGVAASNFARDNKLIEGVVFLASYPMGDELKELGKKVISIWGSKD
                     GVVNFKSLVESKQKLPDDTTYVEIEGGNHAQFGDYGKQKGDNDAIISQEKQLNITANS
                     IIKFLKNIS"
BASE COUNT        20606 a         7549 c        10972 g        17370 t
ORIGIN      
        1 agagtgcgtt cacaaaaaag aagatgttcc gctttctcaa gataacggtg tttgtcgtgg
       61 cactttccct tatcctgctt tcactacttg aaacggtggc tcatgcaacg gggcttgtgg
      121 acgatacgat aaatacagaa aatttatatt ctaaatatcc gttatccaac tatcagcttg
      181 atttttatgt ggataatagc tgggcttggt tgccgtggaa ctggctggac ggtatcggaa
      241 aatcggtaca gtacgggctt tactgtatta ctaacttcgt ttggactatc agtttatatt
      301 taagcaatgc cacgggctat gtggtgcagg aagcctataa gctggacttc atcaatgata
      361 tggcagacag tatcggacag agcatacaga cccttgcagg cgttacctca agcggttttt
      421 caacctctgg cttctatgtc ggtttcctgc ttctcattat cttggtggtg ggaatttatg
      481 tagcatatac gggactgatt aaaagagaaa ccagcaaggc acttcacgcc gttatcaact
      541 ttgttgtggt gtttattttg tcggcttcat ttattgccta tgctcccgac tacatcaaaa
      601 agataaatga attttcaagc gacatcagta ccgcttcttt ggacttggga acaaaaatca
      661 tgctcccaaa ctctgacagc gagggcaagg acagcgtgga cttgataagg gacagcctat
      721 tctctattca agtggaacag ccgtggctac tcttacaatt tgggaacagc aacgcagagg
      781 aaatcgggac agaccgtgtg gaagctctgg tatcggtaag cccagaggac gaggacggaa
      841 aaaccagaga ggaaatcgtg aaaacagaaa tcgaggataa cgacaacaac attctgacga
      901 taccgcaggt agtaaaccgt ttaggtatgg tgtttttcct cttattcttc aacttaggta
      961 tcacgatatt tgtattcttg cttacgggca tgatgttgtt cagccagata ctttttatta
     1021 tctttgcaat gttcctgcct attagtttcc tgctctctat gataccgagc tatgaaagca
     1081 tggcaaagca ggcaatcgtg agggtattta ataccataat gacacgggca ggaataacgc
     1141 tcattgtaac ggtggcgttc agcatttcca gtatgtttta caatatctcc acagactacc
     1201 cgttctttat ggtggcgttc ttgcagatag tttgttttgc aggtatctat atgaagctgg
     1261 gcgatttaat gagtatgttc tcacttaatg ccagcgacag tcaaagcatg ggacgcagga
     1321 tattccgcag accgtatctg tttatacgac atagagcgag aagaatggag cgacgtatgg
     1381 caagggcggt aagtgctggc ggtatttcgg gcggtgtcgc tggtgcgctg gctggcagta
     1441 ccgtttctaa tgcaaggaca acaagaaaca atcctacaaa ggaaaatcgg ggcaatacca
     1501 cttccatcat gggacagcgt gcaggctcaa agataggcgc tgtcttagat acgaaaaata
     1561 aagtgaaaga caaggcaaat gctgtcaaag agaatgttaa ggatatgccg acacagaccg
     1621 cttatgcggt gtattctgca aaagaaaagg caaagtccag cgtgtccgac ttcaagcgtg
     1681 gcatggtgca ggaacagcaa tccagacaga cgggacgctt agaaaagcag gaacaacgta
     1741 aaaaaaatat cgctaacaag cgtatggagc ttcaaaaggc acaagaagca aggcaggcac
     1801 gaaaggctga cggatcagcg acaacgggag ctacccgtcc ccatgagcga ccagccacag
     1861 cttcaaagcc gagtgtggaa aaagtgcagg aagtcaaacg ccctgccaca actccgactt
     1921 caaaagcaag tgagccagtc aagacaaatg ttatcaaaga gcgtccgcta tcttcgggtg
     1981 cttctgacgg aaaagcaacc cagtcggcac agccaataca taggcagaat atagaaaaag
     2041 tggtatcgca ggaaacacgc cagaattacg ttaaagaccg caggacaaag gttcagcaga
     2101 cgcagagcgt ccagaagaac cagcagacca cagagaaaaa ccataacctt gtaacgaaga
     2161 aaggacagaa gaaaaaatga aactgaaaca tatcgctctt atcggcagtc tgtttcctat
     2221 cctcttttcc atagtccttt tttttggggt gctgattagt gcggacagcg acgacgaaaa
     2281 cagcaacttt tcttctggta ttacgggttt gaacctatcc gcagaagtct tgaaacatca
     2341 gcctatggtg gaaaagtacg ccagagaata cggcatttcc gagtatgtta atgtattact
     2401 ggctatcatt caagtagaaa gtggcggtac agcggaagat gtcatgcagt ccagcgaaag
     2461 tctgggacta ccgcccaact ctttagatac ggaaagctca atcaagcagg ggtgtaaata
     2521 ttttgcgtcc ctgctttctt cctacaaaaa tcaaggaata aatgacttga atgtggcgat
     2581 acagtcctat aactatggcg gtggctatgt gggatatgtg gcaggaaaag ggaaaaagca
     2641 tacgtttact cttgcagaga gcttcgcctg tgaaaaatcg ggtggaaaga aagtaaccta
     2701 caccaacacg atagccgttg cgaagaatgg gggctggcgg tatggctatg gaaatatgtt
     2761 ttatgtggaa ttggtcaatc aatatctgac tgtaccgcag gtatcgggag aactggcaca
     2821 aaagataatg aatgaagcgt tgaagtatca aggttggaag tatgtctatg gtggcagtaa
     2881 tccgaacact tcctttgact gttcgggact tgtgcaatgg tgttatggaa aagcgggtat
     2941 ctctttaccg agaacggcac aagcccagta tgacgcaacc cagcatatcc ccttgtcgca
     3001 ggcaaaggct ggcgatttgg tgtttttcca ttcaacctat aacgctggtt cgtatgtaac
     3061 ccatgtcggt atctatgtcg ggaataatca gatgtaccat gcaggcgacc cgataggata
     3121 tgcagacctc aatagtagct actggcaaca gcacttaatc ggtgcaggac gagtaaaata
     3181 aaagaaagga cttagaaaat atgtttaaga aaagtaagaa acagacagaa aatgtcaaag
     3241 aaaaaaaggt gcgtactgtc aaggtaggca cacataagaa aactgtaatt gcgttttggg
     3301 tggtgcttat cgtaagtgta agttttgggg tatataagaa ttttaccgcc attgatatgc
     3361 acaccgtaca tgaaacagaa accatacaat taagacttac cgatactaac gggattgaaa
     3421 atttcgtgaa gaactttgcg aagtcctatt acacatggaa caacagcaaa gaagcgattg
     3481 aagcaaggac gcaggcaatc agcggttatc tgacaaagga attgcaggac ttgaatgttg
     3541 ataccattag aaccgatata ccgaccagtt ccacggttac agatgtgatt gtttggaata
     3601 tcgaacagtc aggaacggac actttttctg ctacctacga agtagatcag cagataaaag
     3661 agggagaaca gacaacagca gtcaaggcaa tctatacggt aaaagtccat gtggacgttg
     3721 acggggatat ggtaatcata cagaacccta cgcttgcacc aacaatcgaa aaatcggact
     3781 atgagctaaa gacaccagaa gcagacgcaa gtgtggacgc tgataccata aatgacgcta
     3841 cttcattttt ggaaacattc tttaagctgt acccaatagc gacggaaaaa gagcttgcct
     3901 attatgtatc gggaaatgtg cttgaaccta tcggcaagga ctatctttat tctgaattga
     3961 taaacccagt ctttacaaaa gacggggaca atgtgaaagt caaagttgcc gtgaaattcc
     4021 ttgataatca aacaaaggcg acgcaggtat cgcagtatga acttgtgcta cataaggata
     4081 gtaactggaa aattgtgaaa taataattta aagcgtgcat ttcttataag atttgtacgc
     4141 tttactttta tggtaaaaat tagccttgac aagcgaccgt tggtcgctat ataatgaaag
     4201 cgaaacaaga aacgaccgat ggtcgctata aggaggtatc ataaatatgc caaaaggaat
     4261 tatgcttaca caagaacaac aagaagaacg ccgagaagaa ataatcagtg ttgctttgca
     4321 gctcatagag aaaaatggat tccaaaaaac atcaatgagg aaaattgcga ttttagcaaa
     4381 catgggaaag tccagtctgt atgatttttt caaaacgaaa gacgagattt ttgtatatgc
     4441 agttgagaaa gaaatagaag aaacaattaa aaaggttcat aggattattg ccgatgaatc
     4501 ctcgccggaa cagtgtctta gaaaaatcat gctgaatcat cttggagtac caaagcagta
     4561 tcgaacggtg ctgatgtggt taaatacaga atctgattat ttagaagaag attatcgaaa
     4621 gcggctgaaa actgcgcgtt acgcatatca ggatattata aaatctgtaa ttgaaaatgg
     4681 aatggaatca ggcgtcttcc gtaagacgaa tgccaatctt atgacgcgtt tgttaattaa
     4741 ctccattata tcaatcattt acacatcccg accatcagcc agtccggaga aaatgcttga
     4801 tgaaacaatg gatatatttc tacatggaat tatgaatgat ggaggtgaat tattatgatt
     4861 tattatactc tacccttgtt gcataaacag gcaacccttg aaatggtcgg cggaaaaggt
     4921 atgtctttat caaaactttt gacaacgggt attcctgtgc cggagggctt tcatgttacg
     4981 actacttcat acaagatttt tgttgaaaag aaccatattc agccttacat taataagttg
     5041 ctggacggta ttgacactaa caatacgagc cagcttgaaa atgtatctac gcagataggg
     5101 atgcttttcc ataatggaga aatgccgcag gaagtatcag atgcaattaa aaccgcatat
     5161 gccagattgg gaaatatagc ggtggctgtc cgttcctccg caaccgccga ggatttgccc
     5221 gatgcttctt ttgcaggcca gcaggaaacc tatcttaaca tacaaggtga gaatgaagtt
     5281 cttgacgctg taaagaggtg ctgggcttcc ctatggacag ctcgcgctat tgcttaccgc
     5341 gtgaagaatg atataaagca ggaaatcgtc gcacttgctg ttgtagtaca aaagcttgcg
     5401 ttttccgatg cgtccggcgt tatgtttacg ctaaacccta tcaatggcag acgtagcgaa
     5461 atgattgtta acgccgcgtg gggacttggc gaatcggtgg tttctagctt agtcacccct
     5521 gatacaatcg ttgtagataa aaatgctgaa cgaattgtat cgtatgaagt agcaaacaaa
     5581 gagattatga cagtacgcaa ctcagatgga acagaagaaa tcccaactcc tgaacagttg
     5641 aggaaaaaac atgctcttac tcgcaatcaa gttatgcgat tgacacagct tggaaaaaaa
     5701 attgagaagt attatgaaat gcctatggat gtagagtggg cactggaaaa agataagttg
     5761 tatattgttc aggctcgccc cattactgtc ctaccgccgg aatggacgtt accagaaaag
     5821 gatgttatat atacaagagg cagtctagcg gaacacttgc caaatcctgt tacgccctta
     5881 ttcgccacac ttgggcttga aatagtcaac cgtgcgtcgg cgcttttatg gatagatatg
     5941 tttggtaaaa gtgcgaaaaa gctactgcca gaaaacggag catatacgat tattaacgga
     6001 tatgtttatc tttccgctaa ttcaaagcct cttttgattg ctgtcaaatc cctttcaccc
     6061 cgatctttac gccgtgcgct cacgaacagt gttgcacgct gggaaacagc acgaaaagaa
     6121 tttgaggatg tgattaaaca atgggaagaa aagcccatgc atatgctgaa tgctcatcaa
     6181 ataatggagg ggattcagac tgtattttat ggagcgtgta tttatttcac gaggattcag
     6241 cttacattgc cagccgcctc tatcagcgaa acattattta caaaattttt tcagggggcg
     6301 gctcgtcgcg ctggtatgac agatacttct gttttcctgc ttggatttga tacgattgct
     6361 ctgcaagccg aaaagaacct gtggagtctc tcggaatggg taaagcaaaa taatactctc
     6421 aacctttatc tgcaaagtaa tccaacagca aagatagcgg aaaattttat gtcctcagtt
     6481 ccgcctgacg aagtttcact ggaagtatgg atagaatgga aaaatcgaat caatcagtat
     6541 tttaaagagt ttggtcgtac cgcttatgaa tttgattttg catattccac accgcaggaa
     6601 acacttacac caacctttga atcgataaaa acctttgtag aaggcaaagg tgaaagtcct
     6661 tttttacgtc aatccaaatt tgaaaagcat aggaaacagg cagaagaaga aattttacaa
     6721 catataggta gctcacgcaa aaaactgttt ttgaagttgc tccattgggc acaggaaact
     6781 gctcctatgc gtgaaaatgc tatttattgc atgggaatgg ggcatcctct gattcgccag
     6841 atgtttcatg aaatttcagc acgccttata cgtggcggag ctacttcgca tatagatgat
     6901 atttattggc tcacaaaatt ggaattggaa aaactcatag tacagttaga caaaaatata
     6961 cctttatccg atagaagaaa ttcgatactt gcgcgaaaag cggaactcaa aaagtatcag
     7021 ggctatatgc caccagctca gttacctgag aagaaagtaa aaagcatatc acatgcacca
     7081 cagaaacaaa aagatggaaa aaccgtgttg aggggtatag gaaccagttc tggtgtcgtg
     7141 acagctcgtg cctgcgtact aaatagtccg gcagatttta aaaatttcca gccaggaagt
     7201 gttttggttg ccgttactac aactccggct tggacaccct tatttgcttc agcaagtgga
     7261 attgtaacgg atattggagg tcctctcagt cattcaagta ttgttgcacg ggaatgtggt
     7321 atccctgccg ttatggcgac acacacagcc acgagaagta ttaaaaatgg acaaatgata
     7381 acggtggacg gctcggaggg gacggtgacg attgatgaat aaaaagccga ttttcgcttt
     7441 aaatcttgct actttggtga ttgcgttagg atatagctta attcttccgg tcatgccatt
     7501 ttacatggaa aatctaggtg ctggcggtcg tgagcttgga tggctcactg ccgtatatgc
     7561 cctggcacaa acagtatgcg cacctttttg gggtgcactg tccgaccgaa ttggtagaaa
     7621 gccgattatc agcattggta ttataggata ttccatcagt ttgttcctgt tcggtttggc
     7681 ttcatccttt tggacactat ttatagctcg cagtttatcg ggtattttgt catctgctac
     7741 gtccgttgca tctttggcat atgttggaga ttccagctcg gaggaagaaa gaagcaagaa
     7801 tatgagtcaa cttggagctt caatgagcgt tggcgtaatg atgggaccat tattgggagg
     7861 cattcttgca ggctattcgc ttgcgctccc attttttaca ggagctggca tttcatttat
     7921 tgcgtttctg ctaattctaa cacttttgcc agagtcaatt gagcgttcag gacagacgga
     7981 aaaaagaaaa ccctttgatt tttcagacct gaaaagtata atttttggct cagcaggaat
     8041 ggttttgata cttattttcg tcgtgcattt ctgtcaaaca ggcttgcaag gaattacggg
     8101 gctgtatgtc gtagataagt ttggattttc cactaagcaa gttggtgtta tttggatggt
     8161 gctagcaggt attttgattg tagtacaagg ctttttgact ggtcctttag caaaaaaaat
     8221 tggtgagaag cgactaatac tgataggtat gttttgcaaa gccttagtag cgtttgccat
     8281 ggtattgaca actgggtttg ttagtgtgtt ggtggttttt ggcttatttg cggtatcttc
     8341 tgctattaca gtacccacat taaacgcaac cctttcaaaa actgacaatc agcataaagg
     8401 aacactgatg ggatttgcca gtaccgccgg aaatcttagc aaagttattg ctcctttatt
     8461 aactggttat ctgtatgaaa gcaatattga attaccatat ataaccacgg gagggatagc
     8521 cttaatcgga gtggttatct gctatatctg gataaaaaat caaaagaaca aatgatggaa
     8581 gaggacgttt atatggaggt tatacacagt aactaatctg gtatagaaat tcaattgagg
     8641 cttttctgct ttattaaagt cttgctacta cttaaaccta taatatcctt aattcattat
     8701 gacaaattcc aattcaacag ttttgataca cataaggagg taacaatact atggaaaatt
     8761 atcaatgaag tgctaattct ttatcagtga agttatccat aagtttttct acctgtaatc
     8821 gtctggtgct ttttgccaga tcattggtag gtaagaaaaa ttcatcaaca gacacatgaa
     8881 gtaatgatac aaggtcactt gtatgcttgg atgttgccct ttattttcaa tattagttaa
     8941 gtaacgtggg tcaatatttg taattcgatt ttagggaaat atttaaagaa atattttcgt
     9001 tttatttctt taaatcttca agaatattga tagttttttt gaaagtaggt gtgtattatg
     9061 aagaatgaga aaaaaattac agtcgcattg ctcattgttt atttattgat tttatcatgg
     9121 attattttat ttaagctaca attttcattt tctgtgttag accacataag acaaataaac
     9181 ttaattcctt ttggtggttc agttattgca aatggaaaaa ttgacttcga tgaaattata
     9241 aacaatgcca ttgtttttat ccctgtaggt gcatatttca gtttgctttt taaaaataaa
     9301 tctgttctaa aagcaatagg ttctgtttta ggaattagct ttgtatatga gataattcaa
     9361 tttatatttg ctatcggagc aagtgatatt acagacttaa ttagcaacac attagggggt
     9421 ataattggaa ttgcattagt atatgtatta tctattgttc taaaggataa aacacataag
     9481 atattaaatc gaatagcaat agtatgtact gtattagtag ttgccttctt atttatgctt
     9541 cttgctgtaa ataatatatt ttaatgccat gttaattaca tgttgttttg gaaaagactt
     9601 taatctgtca aagtttgctt ttgaaattga acatgaaatt acaccaatgg aacaaatgaa
     9661 agctataaat ttttcattgg agaaagatga ctgtacaagt aaagtattaa tatacaatcc
     9721 agacaaatgg aaatatgtag aatactattt ctataaagat agacctatta aaaaactatt
     9781 ggaaaaattt attcaatttt gcatttgtca caataaaata tgttttgaaa tattgaatac
     9841 ttaaatatgc aaaaaaaaca aatgtaactg gctatggggc tatatctact aaaaagctat
     9901 gtgataggtt gggattaaat ttaaacatca cttctagaag gcatgaatac acaaggctga
     9961 caaactatac agttatgatt aaacgatacc aacgggattg aaaatttcgt gaagaatttt
    10021 gagaagtcct attacacatg agcaacagca acgaagctat tgaagcaagg acgcaggcaa
    10081 tctagcggtt atctgacaaa ggagttgtag gacttgaatg tagatactat cagaacggat
    10141 ataccgacca gctctgcggt tacagatgtg attgtgtgga atatcgagca gtcgggaacg
    10201 gacactttat ctgctaccta cgaagtagat cagcagataa aagagagaga acagacaaca
    10261 gcggtcaagg caacctatac cgtaaaagtc catgtggacg ctgacgggga tatggtaatc
    10321 gttcagaacc ttactcttgc accagcaatc gaaaaatcag actatgagcc aaagacatca
    10381 gaaacagacg caagcgtgga cgctgatacc gttaatgacg ctaccgcatt tctggaaaca
    10441 ttctttgagg tgtacccgac agccacagaa aaagaacttg cctattatgt atcggaaaat
    10501 gtgattgaac ctatcggcag ggactacctt tattctgaat tggtaaaccc agtctttaca
    10561 aaggacgggg acaatgtgaa agtcaaggta gctgtgaaat tccttgataa tcagacaaag
    10621 gcaacgcagg tgtcgcagta tgatcttgta ctccataagg atagcaactg gaagatttta
    10681 ggataacatg gaaatgggct tgtatcataa ttatagtgtg caagcccttt tcatattgaa
    10741 gtatcaataa tcaataatta taattaggta catgaatgga gggataaaat gttcaaaatt
    10801 ggtgagtttt caaaattgac acaagtttct actcgtatgt tgcgttatta tgatgaaacg
    10861 ggtttattaa aacctgctaa aattgattca ttaactggat atcgtatgta ttcagcagaa
    10921 caaatctcaa ctttaaatag aattatatat ttacgtgata gtggcttcaa tgtcgctgaa
    10981 attgcattag ccctcaattt cagtaataat gccattatag aacagcttga tagaaagtct
    11041 attgaaatta tggataatat acaaaaagaa caagaaaaac taaagaaaat tgagattgct
    11101 aaaaaagaag tgttacatgg caaaagtgaa ttgtatttta acataaccat taaagagata
    11161 ccgagttatt gcgttttatc tttaagaaaa gaaataccaa attattatta tgagggcgaa
    11221 ctctggaaag aactctctgt ttttgctaaa gaaaataaaa taaatatttc tgatgaaaca
    11281 ttctcaatat atcacaatga agaatataaa gaaaaagatg ttgatgtaga attatgtgcc
    11341 attgtaaata aaataggaaa agctacaggt gattttaagt ttcgttttac cgaaccagtt
    11401 tctatgatgg cttgtactat ggtatatgga gattttttta atatttctta tgcttatcgt
    11461 tcatttgcta aatggcttca agaaaacagt caatataaga tgaaaggttc aagccgtcaa
    11521 atagttcatc gtggaccgtg gaacgagaaa aatccagaga actatctaac agaaatccaa
    11581 attcctttag aaaatctctt gtaaaaaatg ataatctgcc ttgactttaa catggtgtta
    11641 aggtttatcg tttatttatc aagaagaaaa aggaggaaaa tataatgata acttataaag
    11701 tgaattcaat aggtactatc tataataatg aaaaaggtgc tttcattcaa cttgaagctg
    11761 catatatccc agcattaagg gcattagacg gattcagtca tataaatgtt ttatggtggt
    11821 tcagtgattt tgataatacg gattttagaa gtgtattgga aacagaacag ccttataaaa
    11881 atgctccaga gaaaatgggg atttttgcaa caaggtcgcc agtacgtcca aatccgattg
    11941 ctttatcagt agtggaaatt atcaatatcg attatatgaa tggaatgata caaattgctt
    12001 acattgatgc taatgacaaa acgcctatct tggatattaa accatacaca ccgagtttgg
    12061 atagggtgga aaatccaaat gttccagatt ggtgtagtca ttggcctcat agtttagaag
    12121 aatccgcttc ttttgcatgg gaaaacgaat ttaattttta aggagtgatg aaccatgagt
    12181 ttgcaggatt acattattga aaaaccagta attgatacag aacaccttat tttaagaaca
    12241 atggataaaa atgacataga tgatttgaaa gaatggatta gtgatatttc tttatacgag
    12301 tattggggga aacgtccttc aaaaagcgaa aaaaatccag aagtactctt tagtaagcca
    12361 gaaaaagcta ctaaaagttt tcattgggga attgtccata aacaagatag caaagtgatt
    12421 ggtgaaatat ggatatacct tattgaaaat aatagaatgg caaaagtggc tttcagactt
    12481 tctaagcaat atcaaggtaa tggactaatg agtgaagcgt tgaaaagcgt aattgaattt
    12541 tgtttttcaa aaacagaatt acaaaaaata tggacagatg tgcatatttt aaatcatgct
    12601 tcttacaaga cattggagaa agtcggtttt caaagggaag gacatattcg agggggaaaa
    12661 atggtaaata cctattgcga ctactaccta tatggaattt taaaatctga ttatatcact
    12721 agctgatgtt atggctaata ttgaagcgac gattggcgaa gcaatgaaca atacagttcc
    12781 aaaggtctat gatacgaaaa gcattaaaag atatgtgatg aatttattag atatggctca
    12841 ttaaaaagta ccaaagaaat aaaagttacc atatagacaa aattggtttt ttatatcttt
    12901 tgatttctta taagataatg gcattgtgcg acaagctata caaaaaattt tcatgtatac
    12961 tttgattata aattatacaa ggagctaact atatataaat caagtgattt ttgataatta
    13021 gctgaaatat tttttagatc attgaaaagt gaattttgtg tacactgaaa actactgctt
    13081 tatgcagtac tttaaaaata ttcaattgaa tgcttttaaa taagcagttt ttcatcaaat
    13141 tgtatgtttt cagacaacag tttatagatt actcttatga gttttcgtac ggaatgcccc
    13201 tgagcacatc tatgggattt accttgtaag cgttttagtt tataatactt attgaaagtg
    13261 agattgtatt tgcatactgt aagaatgcat tgatatagac tttttcttag gtagcgcgaa
    13321 ccacgtttag acaatgctgt tcgaggtgca ctgtattcac cggactgata agtaccgggg
    13381 tctacacctg caaatcccat gactttgaca gcagagctga agttatgaat atcaccaatc
    13441 tcgcttaaaa tcgacattcc cgtataaatc ccaataccgg gaatcgagaa gataggagaa
    13501 tctagtttga cagctaattc ttctattttt ttgtctacag ttttaagctg actggctaac
    13561 agttcgatat tttcaataag cattttgatt tcaagggtaa cagcttcgtt gttttcgccg
    13621 atagatttct ttgcactgga acgaagagat gatgcatcta tattcacacg gcttccactg
    13681 cttttaggct tgagaacttt tttaagatga gcaagattgg cactggctaa attataagaa
    13741 cttccaaatt cttttaagac agccatataa gctttggaat atttagtttt aaaccaagta
    13801 ttgaactcag gaataacgat atcaatacat ttctgaagtt ggtttttctt ctggttgata
    13861 tcttcagcaa tagaagcatg ataacgggtt aattcacgag cctgtttcat atcgagctta
    13921 cgctgagtga ctctagtata atctctatca aagagtactg aacaaataag aaaagtatct
    13981 tttttatcat tcttagtctt tcttattttg cttttgcgct tggcatcagt tgttaatgga
    14041 tttatcaaag caacttcata atcatgagtg attaaaaaat taataagatt atcaccgtaa
    14101 tgaccggtag cttctaaacc gacaatatgt ctaggtgatt taaatttttt aacagctttg
    14161 ataaaagaat cgaatccgtc tagattatta gtgaagaaaa aaggttcaat aaggacttca
    14221 ccttcagaag aaataacgca ggcacagtga ttgaatttac caacgtctat accgatgtaa
    14281 aacataaaaa gcacatcctt tctttatata agatagtgat atgtgattaa accacaaaca
    14341 gagtatcaaa gagcctggtg caaaatacaa attcgaagac ttatctaact gatcacaatt
    14401 aagatacaaa gatgtggcaa taacctcctt caagtagtca agctacaggt gctgaaagaa
    14461 aaagtacaca ttcacaattc aattctaaac aaaatttaat gaaaggaaaa ggtgtatata
    14521 attgacagat agataagtca attacaatat accaggtact gatatgtacg catatgaaaa
    14581 tattgaaatg tcattaaact atattgaaca acatttaagt gagaaaatcg aaacagagaa
    14641 actggcggaa attgcctgtc tttctacatt ttattaccaa cgcttgttta aaaagttagt
    14701 taagaaatca gttcaagagt atatcaaact tcgccgttta gcaatggtaa tagcagaatt
    14761 gaataattca gaggaaagaa tattagacat agctttaaaa tatggatttt cagaccatgc
    14821 taacttcaca agagcattta aagaagttta ccatattact cccgatgaat acagaaagaa
    14881 tgttcctatg ttaaatacat ttgacaagcc agaactttct tcacgttata tcatgattga
    14941 tgaaaatgtc ccattgattg taggaaatat tgttttggaa attcaaagaa aaacattaag
    15001 aacaaaggaa acatattttg gttttgaaaa aacagtaaat attgctgaac aaattcctgc
    15061 tggagaaagt acaggaattg atgttccagg tcagctatgg cgcgaattcc atgcaaagaa
    15121 actgcaaacc gaaaatgcca tttttaacaa tgatattgaa cttggtgtat ctcacttagc
    15181 aagtccagat aaaggaacat tcctttactt tgcaggaggt atggtttcat caacagatgt
    15241 atgtcctaaa aatatggtac aacatacatt accagcaggt gagtatattg tatgcaaaat
    15301 tgaggcagaa tcttttgaag aacttgttac tactgcttta aatcaagcaa ataagtatct
    15361 gtttgaaact tggcttccaa atcataattt ggttacaaag ccattcatgg cagaaaaata
    15421 ttacaaagga aatgcagaga ttaattatat ggaagtatgg ataattcctg tgtaaacagt
    15481 aaatgctaaa taggaattat ctgacgtaat aaaaaggaaa tagaaagctt ataaaggagg
    15541 gcatagtccg ttgtgataaa cataaaagat ataaattatg tacctaatat tagtgaaata
    15601 agcgtttata ttgaaaactc tgcatttgat gagttgtatc agcatatgaa caatgaatat
    15661 aaagcagttt gcaaaatcga atacagtaaa gatgtctggg cacgaggttg gaacgtaaag
    15721 tttaaaaaat ctgggaaatc attgtgtgtt gtctatccga agaagaacta ctttactgta
    15781 ttggtggttg taggtaataa agagaaagaa gatgttgaaa acttgttacc taggctttct
    15841 gaatatgtac aggaaattta tcgtaacact agagagggaa atggacaaag gtggcttatg
    15901 atagacttaa aatctaaaaa taatgtatat caagatgtat taaggcttat tgaaattcgt
    15961 tatgccataa aatgtgtaaa accgtaataa aaatattttt cacatacgta atctcaaggt
    16021 attatcgttg agacaagtaa cctatataat tatgggaaat gagattttta gatacttaag
    16081 aaagtacttt agggggcttg cgttatggaa agatttaagt acaattccac acaatcaaat
    16141 acaatctaat aaagctttac taaaaattga atgcattaca gctttaaagg ctcgtacaaa
    16201 ctatatgttt tgtgcgggct tttttcattt aataggaatt tggattcgtc agagagtata
    16261 ttataaaaat aaaacgataa gggtacctta aaaataaggt acctcaggct gtagacaaag
    16321 tcccggactc tcgtctgggc ttttcttata tttgagttat ccacaattca actttttaag
    16381 agttatctta ttaagaaaaa agtgtatgtt ttccacccga tagttttact tctgtgatat
    16441 ttgcagatgc cactcaagta gaaagtggtg gtacggcaga agatgtcatg cagagttcag
    16501 aaagtctggg actaccgcct aattccttag acacggaaag ctcaatcaag caggggtgta
    16561 agtattttgc gtccctgctt tcttcctgca aaaatcaagg tatcgacgat ttgaatgtag
    16621 cgatacaatc ttacaactat ggcgggggtt atgtgggcta tgtggcagga aaagggaaaa
    16681 agcacacttt taatcttgca gagagcttcg cccgtgagaa atcgggtgga aagaaagtaa
    16741 cctacgccaa cccgatagcc gttgcaaaga acgggggctg gcggtatggc tatggaaata
    16801 tgttttatgt ggaattagtc aatcagtatt taactgttcc gcaggtgtcg ggggaactgg
    16861 cacaaaaggt aatgaatgaa gcgttgaagt atcaagggtg gaaatatgtg tttgggggaa
    16921 gcaatcccaa cacttccttt gattgtagcg gacttgtgca atggtgctat ggaaaagctg
    16981 gtatctactt accgagaacg gcacaaacac agtatgacgc aacccagcat atccctttat
    17041 cgcaggcaaa agctggggag ttggtctttt tccattcaac ctataacgct ggttcgtatg
    17101 taacgcacgt cggtatctat gtgggaaata atcagatgta ccatgcaggc aatcagcggt
    17161 tatctaacaa agaaattgca ggacttgaat gttgatacta ttagaaccga tatactgact
    17221 agccccacag ttacagatgt aattgtgtgg aatatcgaac agtcgggaac ggacactttt
    17281 tctgctacct acgaagtaga tcagcagata aaagagggag aacagacaac aacagtcaag
    17341 gcaacctata cggtaaaagt ccatgtagac tcttacaggg atatggtaat tattcagaac
    17401 cctacccttg caccagcaat cgaaaaatcg gactatgagc caaagacacc agaagcagac
    17461 gcaagtgtag acgctgatac cgtgaatgac gctaccgcat ttctggaaac attctttaag
    17521 ctgtacccga cagccacagc aaaagagctt gcctattatg tatttggaaa tgtgcttgaa
    17581 cctatcggca gggactacct ttattcagaa ttggtaaacc cagtacttac aaaggacggg
    17641 gataatatga aagtcaaggt agctgtaaaa ttccttgata atcagacaaa ggcgacgcag
    17701 gtattgcagt atgagcttat tctacataag gatagtaact ggaaaattat tatgtaagac
    17761 attttgttgg caggatctat tttcggatat agtctgcctt ttctgtagca aatgtactgc
    17821 actgacaagc tatttcattg tattttaagc aattaaatct ttcttgacaa ttttatctta
    17881 aatcatatat ttatggatat tgactttctg cttgcaataa gttataatat gactataaaa
    17941 ccaaattagt cacataggag gtatgtggta tgtataaaga agttggtatt tcttcaaata
    18001 atgttccgat aacactttct atctggtata cagaaagaag tagtcctacc attgtttttt
    18061 tgccgggtac tatgtcacac cctctcatgt atgagaattt tctatgtggt ttgagtgaaa
    18121 gaggatttaa tataataggc attcactatc tttcacacgg aaaaagccct aaaatcaaaa
    18181 aaaattatac aatggaagat ttgctgcata atgtatatga cgcaacaact tacggaatag
    18241 aaaatttcgg tgaaaacata gctgtcatgg gttccagtca aggcgggatt ttagctgcaa
    18301 tggcggcagg tagggacaca aggttaaaag ccgtttttcc acataatatc atgctgacta
    18361 cattaaaaga aactatgagc ttaacaaaat atcccacatg gtcgcaccgt tttatggggc
    18421 tgatacagtg gggctttcgt gtaggtggaa aattgctgcc taactacaag gttccaggag
    18481 acgcttattt agactatgac agagtatttt atagtgaaca ggcaaaacaa gattgcttaa
    18541 atgaccctat gcttttaccc tattatcctt taagatttgt cgccagctta tttaatgctg
    18601 acttatcgtg cctggagaat ggggctatac aatgtcctgt tattttaatt actgccaaag
    18661 gcgacccgct ttttagcttt gattatacca acaaagtatt tgatttaatt catgtaccgc
    18721 aaaaggaatt acttgcttta gagcttaatc gtcacatgat ttttaatgag gacacggaca
    18781 ctacaataaa cgcattggaa gctaccttgc ataaatatct tggatagcat attgattata
    18841 taatcagtaa atgttatact tttcatgacg atataaatat tttagtcata aggaggttat
    18901 gagtttgcca cgatttacgg aacaagaaaa agaaatcata aacagtaaac ttttgataga
    18961 gggagaaaag ctgtttgcat tacacggctt aaaaaaagta acagttgatg atttagtagc
    19021 tgctgtaaac atatcaaaag gttctttcta tgctttttat cccagtaaag aacatctata
    19081 tgttgaaatc aattttcgct tacaaaaaga gttatttaca agtatagaaa caaccattaa
    19141 aaagaaaaag tataagaacc atagagattt agcaaaggac gttatcatgc taagtttaac
    19201 gggggtgatt acttcgccta ttctttcaca gattgattta tctttaatgg actatctgca
    19261 aagaaaaata tcgtcagata tttttgaaaa tcatatgtac agtgatattc gtatattgga
    19321 gatattggaa gatttagggg ttgtattttt ggttccgcat acggttatta taaaatccct
    19381 gtattctgtt ttatcctgtt tggaacaatt caaagaggac gaagaactga atatgataca
    19441 aaatctttta gtgaatggta ttattcagca agtagtagca gagtaacaat tttgtttggt
    19501 tatttgacag gcaggtagcc aaacaaattt tttacagttt atatgactat atatctataa
    19561 gcgtcataaa gttaaaggag gaatgaataa tgattgatgt aaaaaaactg tattttagct
    19621 atactgacaa accgtttgtg gagaatgtaa gtttccatgt tgggagagga gaaatttttg
    19681 gttttttagg accctctggt gctggaaaat caactattca aaaagtttta actgggctta
    19741 atacaagata taaaggcagc gtaaaagttg caggtacaga aataagggag catacaaatc
    19801 agttttatga aaatattggg gtagactttg aattttcaac ctgctacgag aaattcacag
    19861 cacgacaaaa tctcgcctat tttgcttctc tatatgaaaa gcaacctcgg tctattgatg
    19921 aattattgca tatggtaggc ttggaaaatg acggggacaa aaaagttgct gacttttcca
    19981 aaggtatgcg ttctcgcttg aatttcatta aagcgttagt ccatgaccct gatatattat
    20041 tccttgatga acctacaagc ggtcttgacc ctacaaatag tcgtttaatg aaagatatta
    20101 ttcttgcaga aaagaaacgc ggaaaaacga ttatcattac tactcacaat atgtttgacg
    20161 caacagagct atgtgaccaa gtagccttta tcgttgccgg aaaagtcagt gcattggata
    20221 gcccgcataa tttgattatg tcaaggggag ctgccaaaat acaatatacc tactatgata
    20281 aaggcgagaa aaccggagaa tgtctgcttg atagaaccac agaagataag ttgttaaaaa
    20341 gtttaatttc cgaaaaccgt ttgctttcta ttcatagtag tgagcctaca ttaaatgata
    20401 tttttgttga tattacaggg aggacacttc aatgagattg ggacgtttaa tttgtggtga
    20461 tatacatttc caatggaaat atggtttcta ttttatctac tttatattaa cagttttata
    20521 tgtgtgcggg attgccgctt tgccggaaca ttggaaaacg gatattgctt ctattatgat
    20581 ctactctgac ccggcagcaa tgggattatt ttttatggga gcgattgtcc tcttagaaaa
    20641 aagtcaaaag gtgttaaatg ctatggtagt atcgcctgta aaagtatcgg agtacatact
    20701 ttcaaaaaca atcgcgttga ttgctatttc tacggtaatc gcattgatat taggggtagt
    20761 ttccgacagc aatcatttac ttggtatcac agttggtacg gctttgacct cagcaatctt
    20821 tactatgctt ggaattattg cagctacaaa aatttcaaac ttgaaccaat ttctcattgt
    20881 gattatgccg atagaaattg tttgctttgt accacctatt gttggtctgt ttgtgaagtt
    20941 accatatctg ttccgctttt ttccattcac agcttgcatg aaccttataa ctggaaaaag
    21001 cgttttacta tcgtttgata tggtacttgt aattgctacg ttgattatcc tctacatagt
    21061 tgcgcgacat acagttaagc atatgtggaa aagtttagga ggtgtaaagc tatgaaaagg
    21121 atattatcca gtaccataca ggtatttaga caaatcaaga gtgaccctat gatgtttgca
    21181 gcttgtttta cgccttttgt catgggagct ttgattaaat taggtattcc ctttcttgaa
    21241 agaataacgg atttttcttt gcaagcatac tatccgattt ttgatttact actttctatc
    21301 atggctcctg tattactctg ctttgcattt gcaatgatta cattagagga aatcgacgat
    21361 aaagtgtcac ggtacttttc gattacccct cttggtaagt cggggtatct ctttacaagg
    21421 ttgggagtac cctcaattat ttcggcggtc atcgctttta ttgtactgtt acttttttca
    21481 ttagaaaagt tgtccattgg aatgacaata tgtttggcgc ttctcggctc agtacaggca
    21541 attattgttt cacttatgat tatcacatta tcaagcaata aattagaggg tatggcagtt
    21601 acaaaactag ctgcacttac attgctcgga ataccagccc ccttttttat tgatagttac
    21661 taccagttcg cggttggctt ccttccatca ttttgggtag cgaaagccat gcagaatgag
    21721 gcggttcttt atttctctat aggattggtg gtagctttag tctggtacta cttccttaca
    21781 aaacgtctgt ttcggaagct ggcaggataa ggaggcatat tatggaaaag ggtagacttc
    21841 tgcaaaacgg aaaagtaaat agagctattc aggtttccaa aatcacacta tttatcaacc
    21901 taagtttatc gttacttaaa tttactgccg gatatatagg aaagtcaagt gccatgctgt
    21961 cggacgctgt acactcggct tctgatgtat taagcacaat cgttgtgatg gttggaatta
    22021 aaatatcaga aaaacagcct gatagagaac atccttatgg gcatgaacgt atggaatgtg
    22081 ctgcttccat tattctctct gttgcattgg ccataacagg tgctggaatt ggatattcag
    22141 gtatcaagaa aatcttttca gaacagtaca atacgctttc tactcctagt ggaatcgcac
    22201 ttacggcggc agtcttatcc attgttataa aagagtggat gtactggttt acaagaaatg
    22261 ctgcaaagca tacaaattct gacgcactta tggctgacgc atggcaccac cgctctgatg
    22321 cactctcgtc ggttggttcc ttaattggca ttttaggagc gcgtttaggc tatgctattc
    22381 tcgaccctat tgcaagcgtt gtgatttgcg gttgtatctt aaaagctgct ttggacattt
    22441 tcaaagaaag cattaacaaa atggtagacc atagttgtga caatgctact gaaacaaaga
    22501 ttagggaagt tgtgcttcag cagcaagggg ttgatggtat tgatgaatta aaaacccgca
    22561 tgtttggagc gaaaatgtat gtagatattg aaatattagc tgatggtaat ttagctcttt
    22621 atgacgctca tagaattgct gagggagtcc atcaaacgat tgaaaacaac tttccacaat
    22681 gtaaacattg tatggtacat gttaatacga atgaacttct ctattctgca taggacaggg
    22741 aagatgattt aaggctattg aaagggaaag gagggaagta ggttatggaa caatactggt
    22801 ggattatcat tgttgtggtt ttgattgtcg ttggtttact taaaattgta attatgaaga
    22861 agtataacca aaggagaaat tctaacaata gtccaaaaga tagcgaggac gacaagatgt
    22921 attaaggttt attgaaatct gttatgttgt agaatgatgt ttttagatac tagaaagtgc
    22981 tttaaggggg ctaacgttat ggaaagcttt gagtacaatt ctttccaatc aacagtattt
    23041 tgcatagaga aatgtatgta ggaaatatgg tgcaaggcat aaagcaccag cgatcgagag
    23101 atcaacctat gaaccaaagg cacactacat tttatactac ttgacaagta aacgagcgtt
    23161 tactataatg gtttacagaa gtaaacgttc gtttactaaa gaaggaggtt gtaaatgtct
    23221 gacacaaaag aaaatatatt aaaaattgca ctacacttat ttgcagtgaa tggttatgag
    23281 gctgtttctg ttagtatgat tgcggaagcc ttgggaatga caaaaggagc attatataaa
    23341 cattataaaa ataagcaaga tatttttgac tgtatcgtag aacgtatgta tcaaattgat
    23401 aataagcgag ctaaggatta tcaagtacca gaaagcacaa tagaggtaac ccctaatgca
    23461 tacagaaata caactattgg aagtctaata acatttactc ttgcacaata cgatttttgg
    23521 gtgactgatg aatttgcgtc taattttcgc aaaatgttaa tactagagca atatagaaat
    23581 ttaaaagtga atatgcttta tcaaaaatgt cttgtaaatg gtcctatcag ttatatagaa
    23641 gatatattta atgaaatgat tgaaaaaggt gttcttcaag agtgtgatac aaaacagctt
    23701 gctattgaat attatgcgcc attatttcta ttgataagtg tagcagacgc agttgaaaat
    23761 tgttgggatt taaaaactca attaactaca cacgttaaac aatttgtcaa gaaatatatt
    23821 ataaatgaga aagtaaaata atcctttatt ctgtcctaaa tataaaccta actttttaat
    23881 ttcagcagag aaactcaaaa tgaagattgt tataagtcac aaatattaac tattaaaata
    23941 ttacaataac ggagatgaga aaatggaata tattcgcagt aaaaaatatt ttacacccga
    24001 cttacagaca aaaattatgg ggccgaatcc tataaaatta caagaggaac tattacaaaa
    24061 tcataaaatc ccgtctggta gctatgtctg tgaccttgga agtggacaag gtttaacttc
    24121 tgtatttctt gcaaaagaat atggatttgt tgtttttgca gttgacttat ggagtgagcc
    24181 aaaagaaaat gaagaatttt tcaaaaaaat gggattatct tctgcacaaa ttaaatctgt
    24241 aaaagctgac gccaatgaac ttaaatttga gaaagagttt tttgatgctg tagtaagtac
    24301 agattcatat aattattttg gacgtgaccc tatatattta gatgaaaaat tgcttccatt
    24361 tgttaagaaa ggtgggtttg tttatatcac agttcctggc atgaagaaag attgccatga
    24421 gaaacttcca gaagagttat tgttatcatg gacaccagaa gaacttgatt atatacatga
    24481 tataacatat tggtctaaca taattagtca ttgtaaaaag gcagatttaa tttcaatata
    24541 tgaaatggaa agtaattcgg aagtttggtc ggattggata aagcaaaata atgaatatgc
    24601 aataaatgac cgtaaggcaa tagaagctgg cggtggagat tatctgaatt ttattgctat
    24661 aattctacaa aaaaaataaa ttctttagaa ccaaacacta taatttgcgt tctaatatgt
    24721 ttaccgattg acatcaataa ttttattttt gagggtaatg atttgaaaat agaagaataa
    24781 ttccagtttg taaaagtcaa taaatccaaa gataaatttg tatttgaaag gagttttgaa
    24841 aaatgaaaaa atatgagtat gtagaaatta actataatgc gaaaggagtt gtattccttt
    24901 gtactgataa acacaaagaa attattgaca gttacgcaaa aacggggtat cactacgcag
    24961 ggtttgtacc cacagaaatt gacgcaaaag gctgtatgcg aaagatagat ttaatttttg
    25021 aaaaagaaga ttaacttatt ttagggagtt ggttctaatg ataggactta aaagacgaaa
    25081 tatgaattat attatgaaag ttggtgctaa agctcaaggt gtttctgtat ctgaatttag
    25141 ggctatgcta caagatacca tagacaaaac tatggaaagt acagacccag acgtgcaggc
    25201 aaattttaaa cgatactttg gaaataagcg cccaacacca gaggaatata tttatacgat
    25261 taccaaaaag acaaaggtta aggtttaaat gttgtaaagg gggcttgccg tatgaaacgc
    25321 tttatgtaca attcagtata ttcaagccca atttaacagc atactattta caattaaata
    25381 cgctatacca gtagctcgta caaaatttat attttgtgcg ggctttttta atacccgaaa
    25441 agttttttta attattttca tttttttgga agcaaatcac accttgctgt acagatatgg
    25501 tgcggaaaga gggataaaca cttttcaatt catagctgga aaggaggtga gattatgaaa
    25561 ccgtctgact tccaaaaaac aattcagtgt cagtttgaat gtaagctgaa aaaagttgtc
    25621 aaaggtatta tctggaacta ccgtaaagaa ttaaaacgaa gaaaaaacaa ggaaatatct
    25681 tttagcgaat taccagacat tacggtagaa agtctggcaa catgggacga ctacgaaaca
    25741 aactacacaa tttttaatgt gtgtggcata gatattaaag tccttgatga tgaacttgca
    25801 gaagctctca aacagctacc cgaaaaaaaa cgtaacaatg tattgatgta ttacttcttg
    25861 gaaatgagtg atacagagat tgcagatatt atgaattata ccagaggggc tgtgttcaaa
    25921 cacagacacc gtgccctaga aactatgaaa gagatactaa aggagaagaa atagaaatga
    25981 agaaaaagta caagcacccg tcttattatt tgatttcatc agctatggac ggggatgaaa
    26041 ctgcgattga gaaattactg gtattctatg acccgtacat atcaaagtgt tgtttacgtc
    26101 ctttatatga tgaatacggc aatgtttata ttgttgttga tatggaatta aagggacgta
    26161 ttcgagaagc cttaatcaaa atgattttag actttgagat tgatatagat atagaaaccg
    26221 aagaagaata agcagatacc agcagggcgt gattggttaa acctcctctt tcctgccctg
    26281 ctcctgcttt tatacatgga agcctacggc tttcgccgat tgttctttga caactgaata
    26341 aagcagacag atacgtttgt gatacagcga gccacgggga ctgtacgcca tgacctttcc
    26401 gacaagaaag tgagcgaccc acgcagtgat ccgagagcaa cttgtggaat ggtcgctttg
    26461 ccatgacctg ctatcacaga ataatgatac gtccgcatgg tgcggttctg cccacaagaa
    26521 tgggaatagt tgagatacta acggagcttt ccgaagccgt ctgtctgctt atgataagac
    26581 atacagaaag gagtgttgca acatgaacaa tactgatgtg cctatctggg aaaaatatac
    26641 ccttagtata gaagaagcgt cccgatattt tcgtatcggg gaaaagaagt tgcgtaggct
    26701 tgccgaggaa aatctggact ctggctgggt tatcgtcaat ggaaaccgta ttcagataaa
    26761 acgaaaacag tttgaaaaaa ttattgatac actggacgaa atctgatgtc ttagagccgt
    26821 agatatggta taatattagt agcgtatcac ggctcattcc atgacggaaa ggagctttac
    26881 accatgtcaa aagtgaaaag acaagacagt aaaggacgca atttgcgtct tggagagagc
    26941 cagagaaaag acggaagata cgtttataaa tataccgata tattcgggaa gccacagttt
    27001 gtatatgctt ggaaacttgt acccacagac aaaacacctg ctggaaaacg tgatgatata
    27061 tcgttgaggg aaaaagaaaa gcagataaaa aaagaccttg acgacggtat cgacacagtg
    27121 ggtggtaaaa tgacagtctg ccagctttac gaaaagaaga acaatcaaag aaagaacatc
    27181 aagagaaaca caaaaatagg acgacagtat cttatgaacg cactggaaaa tgacccattg
    27241 ggtatgaggg cgattgatac ggtcaagcag tccgacgcta aagaatgggc tatcagaatg
    27301 aatgacaaag gttattccta caaaacgata gataactata agcgttcctt aaaggcttca
    27361 ttctatatgg cgatacaaga cgactgtatc agaaaaaatc ctttcaattt caagttgagt
    27421 gatgttctgg aagatgatac ggaagcaaag gttatcctaa caccagagca ggaagaaaaa
    27481 ctccttgcct ttatggaaac agataatgtc tacagcaagt atcgtgatga agttattctt
    27541 ctgctggaaa cgggacttcg tatctctgaa ttatgcggac tgacaacaca cattgatatg
    27601 cttaaccgtg tgattaacat aaaccaccag ctattgcgtg atacagaggt gggttactat
    27661 atttccacac ctaagacaaa aaacgggaag cgtaagcttc cattgacaga aagagcatat
    27721 caggcacttg aacgaatttt aaagaaccga ggaaaagcac aaccgcttgt tgttgacggt
    27781 tacagcaact tcttgttctt gaaccgtgag ggattgccaa aggtggcagg aaattatgaa
    27841 agtatggtgc gtgggctgat taagaagtac aacaagacgc ataaggacaa gttgccaaac
    27901 atcacgcccc attcattcag acatacttac tgtacgaaca tggcaaataa gggaatgaac
    27961 cctaacaccc tgcaatacat catggggcac gcaaacataa ccatgacatt agggtattat
    28021 gctcacggta ctttccagtc tgcaaaggct gaattagaaa ggctggcttc ttaatatcga
    28081 aaatgtatct tactacttat ttactacttt tggttgcatt ttcatgctgg taaatgccat
    28141 cttatgcgag gtatcttcca aaaggaaaat gccaataaag cccgaaaata tgggatatat
    28201 cggcatttac caacttatga aaagataatc agaaatttag taagttttta tatcaaaaat
    28261 agtaataaag tctatataca tttagaaaat actgtttaaa aggagtagga tttatgataa
    28321 aaaaagagat atctaacttt agaggaagta gtgattatgt agtatcacca gaattgatgg
    28381 catcagttaa tgttgctatt gctcttgaaa agccactttt gattaagggc gaacctggaa
    28441 caggtaaaac tatgctagca caagcaattt caaatgaatt aaaaaaagat ttagtaattt
    28501 ggaatataaa atcaactaca aaagcacaag aagggcttta tgtatatgat actgttcaaa
    28561 gactttatga tagccaattt ggaggagaag gtgtagatga tattagcaag tacataaaat
    28621 atggtaaact aggagaggcc tttagctcaa atcaacaagt aattctttta atagatgaaa
    28681 tagataaggc ggatttagaa tttccaaatg acttgctttg ggaattggat aaaatggagt
    28741 tttacataaa tgagacaaaa gaaactgtaa gagctaaaca aagaccaata gttattataa
    28801 cttcaaatgc ggaaaaagaa cttccagatg cttttttaag aagatgcata tttcattata
    28861 tagaatttcc tgatagagac atgatggaag aaatagttaa agtacatttt gataaagtag
    28921 aagaacacct attggaacaa gtaatgacta ctttttattg gattagaagt ttaaaggaca
    28981 tacaaaaaaa gcctagtaca tcagagttaa tagactggat acaagcatta actttgagtg
    29041 gaatgcctat tgaaaaaata gaaaaagaag ttccttttgc aggaatacta cttaagaata
    29101 atgaggatat tgaatctatg caaagacact tatagttaat aggagctgga taattatgtt
    29161 tattgaattt ttttatttat tgaggtcaag aggattaaat gtatctttaa atgaatggat
    29221 gactttaatt gaagcattgg ataaaggact gtgctattca aacttttcaa atttttacta
    29281 tctttgcagg atgattttaa taaaaagtga aagtgatttt gataagtttg atgcagtgtt
    29341 tttggagtat tttaaaggta tagaacacca agaagaaatt ccagaagaga ttatgaattg
    29401 gcttaaaaaa ccagatatag atttagaaga gtttgaaaga ttagaacaaa atccaaatat
    29461 aaatcttgat aaattaagag ctaaattgga ggaacgaata aaagaacaag actctcctca
    29521 taatggtggt aattattgga taggcacagg aggcacttca gagttaggac attcaggaaa
    29581 agggcaaact ggtatacgta taggtggaaa ttctacttat ggtagagctg ttcttgaagt
    29641 tgcaggagaa agaaaataca gagattttag agatgatgaa gttttaaata tgcgtcaatt
    29701 tcaagttgca ctaaagagac ttcgtcaatt ttctaccaga atagatgctc caaagacaga
    29761 gcttgatttg gataagacta ttgaagagac ttgtaataat gcaggatatt taaagttatt
    29821 ttttgagaag ccaagaaaaa atacagtgaa gcttttattg cttatggatt caggtggttc
    29881 aatgagaggg tatagcactt tatgtaatac attatttcag tctgtaagta aatcaaatca
    29941 ttttaaagat gtaaagatat attatttcca taactgtatt tatgatagat tatttacaac
    30001 acctgaatgt tggttaagta aatctattaa tactgaatgg atattaaaaa atatagataa
    30061 aaactataaa gttataattg ttggagatgc ttctatgtcg ccttctgagt tgcttcatat
    30121 tggtggtaac tatcgtggtc catataatta cacacctggt atagagtggc ttaaaaggtt
    30181 taagagaaag tacagtaaaa ttgtatggat gaatccagaa cttagagatg gatgggattc
    30241 aattaattat tggtatcaaa ctcaaagaat gatacaaagt gaatttaata tgtttccatt
    30301 gactgtaaaa ggtcttgaga aagcattgaa aaatttaatg gtttcaagat aaagtaaata
    30361 taaatgatgg tatgatttat tcaaaattgt accatcatta tttatttttt ttaatatatc
    30421 tattataaat tgtataactg aaacttaaaa aattatatag tctaatacat tttagactca
    30481 cacaaaacat atacattaat aataatttta gaagtcgagg tgattataat aaattatgaa
    30541 ttaattgtaa aatacaatgg agatatattg aggttagaag aagaattagg tgtatcagta
    30601 gagatactta attcatcata tgcaataata acatcaagta atgaagaaga tgtaaatata
    30661 cttttaactt atccagaaat tgaatttata gaaaagcctt ttatattaca gactcaggat
    30721 gtgcaaagtt tttcaagtac aggaataaca ggatttaaaa atagaactgg tttaactgga
    30781 aaaggaacta taattggtat aattgattcg ggaatagatt atactctacc tgtgtttaga
    30841 gatagtgatg gaaggtctaa gatattatat tattgggacc aatctattca aggaaatcca
    30901 ccagaaggtt ttagagaagg aacattatat actaatgaag atataaataa tgcaatagat
    30961 ggaagtatgt atatacctat ttcaacaact agcttacatg ggacacatgt tgcaggtatt
    31021 tgtgcaacta ttgcaagtga tgccagaata atagtggtta gagttggaaa tatacagacc
    31081 gatatttttt cgagaagtac agagtttatg agggcaatta aatttatttt agatagggca
    31141 ttagaattaa gaatgcctgt tacattaaat ataagttatg gaagtaatga aggttcacat
    31201 agaggaacat ctttatttga acaatatata gatgatatgt gtttattttg gaaaaacaat
    31261 atagttgtag cagctggaaa taatgcagat aaaggaggtc ataaaaggat taggcttcaa
    31321 aataatatta cagaagaagt tgagtttata gttggggaag gagagcgtat attaaacata
    31381 aatatatggc cagattttgt tgatgatttt agtgtacatt tggtaaaccc atcaaataat
    31441 caaacacaag caatctctct aacttcaggt gagataagga atactttggg tgaaactaga
    31501 ataactggtt atttttaccc tatagcaccg tattctctca caagaagagt tactctacaa
    31561 ttaagttcaa atacacagat aactcctggg ttatggaaaa ttgtatttga accaatagat
    31621 atagtaactg gtaatgtaaa tatatatttg ccaacttctg aaggtctgaa tagaaatact
    31681 agatttctga ttcctactca agagcttact gtaacagttc ctggaacagc aagtagagtt
    31741 ataacagtag gtagttttaa ttcaagaaca gatatagtat ctatattttc tggtgaagga
    31801 gatacacaat taggtgtttt taaacctgat ttattagctc caggtgaaga tatagtatct
    31861 tttttaccag gaggtacaag tggagcatta actggaacta gcatggctac acctcatgtt
    31921 acaggggttt gttcattgtt tatggaatgg ggaattgtaa atggaaatga tttatttttg
    31981 tattcacaga aattaagggc attacttcta aagggagcaa ggagattaag taatcaatct
    32041 tatccaaata attcatcagg atttggtttt ttaaatttat cagatataga tttgtacact
    32101 ctatctaata taaatcaaga tttagaaaca gaggatattg gatatagaag tattaataag
    32161 tcatttaaag atgaggaaaa tagttataag tttatagatg gttataatat gcaaatacat
    32221 aatgacttag agaatgaaat ttatataagt aaaaatgcaa gtagacaatc aggaatacta
    32281 tcaggaatag atatagtcca tactcctgaa tttgaagaag aactagctgg gttaggtatg
    32341 agtcaaaggt tttttaagat aagtgattca ttaggtgtac tatctataaa taatacagac
    32401 tataatagca tacaacgagt tttgcaactt ccttcaatca taagaactgt atcgactaca
    32461 aagatgacat tacttggaga aattaatcga ggtacttttg gaggtgtagt tgcaacagaa
    32521 gaaatgggcg taaatttctt taaaaataat cctaatatta atataacagg aagagggact
    32581 ctaatatcaa ttgcagatac aggaatagac tatctacacc cagattttat ttatccagat
    32641 ggcacttcaa aaatagtata tttatgggac caaacaaaag aaggaactcc tcctgatggt
    32701 ttttatattg ggacagaata tacacgagaa gatataaatc gagctatcgc agaaaatgac
    32761 cctagtctat ctcaggatga agttggtcaa ggaactatgt tgagtgggat atgtgcaggg
    32821 cttggaaatg taaatagtga atatgcaggt atagcagaag attctgagct aataataata
    32881 aaactcggca agatagatga tttttataat agtgcaatgt tgtttgctgc atctcagtat
    32941 gcatataaaa aagcttttga acttggaaga ccattagtta taaatatgtc tttaggtacc
    33001 agtagcctag caggtttaac caataggagt aatagtgaaa aagcgttctt tactagaggg
    33061 ttatgtataa cggcaggagc aggaaatgag ggcaatacac agacacatac atctggaata
    33121 ataccatatg ttggaggttc tgttgaagtt gaattagagt taaatgaaga cgaggaagaa
    33181 ttatcattag aactttggtt aaatagacca gataaagctg atgtaataat agtatctccc
    33241 actggtgaag aaagtaaaag tgttggaatt tcaaattata ataaagtaac aggtttattt
    33301 gatttagagg ggactgaata ttctataaca tatatatacc caacaacttt ttctggacag
    33361 caatttacta atgttacttt aaagaatgca aaaagaggtg tatggaagat tcgattagta
    33421 ggagtttata ttataacagg aagatataac ttataccttc caaatagaga acttttaaaa
    33481 agtggaacta gatttagaga ggtagaccct ttttacacta taaattatcc tgcgattcaa
    33541 gatgatttaa taaccatagg agcctacaat actattaatg gtagtttatg gcaaagttca
    33601 tcaagagggc caactattga agacaggtta aaaccagata tagtagcacc aggtgtcaat
    33661 ataatagctg cttatcctgg gaacacgtat gcaactataa ctggtacagc agcagcaagt
    33721 gcacatgcag ctggtgctgc tgcaatgtat tttcaatata cttttgttga cggtagatat
    33781 ccaaaccaag catatgtgca aaaaataaaa acttttatgc aagctggtgc tagaaaagat
    33841 tcaaacacag tatatccaaa tacaaattct ggatatgggc tcttggatgt tagaggaatg
    33901 tttgatgttt taagatagga gggatttatg gaaaaatctt attgtataat ttatcaaggt
    33961 gatatagaat ctgccctaca agaaaatgga ataaataggt atatggtttt aaatagtcag
    34021 cttgcagtaa tatatgtacc tttagatttt gatgaaacta ttttaaataa tataatacaa
    34081 gttgcttggt gggaagaatc tgaaccaatg agcagtctaa ttgaaataac taataatgta
    34141 aataatggag aaaccattac aacagcagct gaaactgatt atatttatga aaatccatat
    34201 aatgatataa cagggagagg aattttatta gcagttatag attctgggat agattatttg
    34261 catcctgatt ttataaatga tgatggaact agtaaagttt tatatttatg ggaccaagaa
    34321 gcaaatacaa atccacctcc agaaggtttt atttttggaa gtgaatttac aagaagtgag
    34381 ttaaatatag ccataaatag aaatgatggg agtttgagtc aagataatat aggtactgga
    34441 actttagttt ctggtatatt agttggaaat ggaaggataa attctcagta cagaggtatt
    34501 actacagaat cagacttaat agtagttaaa ttaaaatcat atacagatac ttattatgct
    34561 ggaaggataa attacagtgt ttcagatttt ttagcagcta taacgtatgt tactaacata
    34621 gcaagaacag aaaataaacc actgataata aatttgacta ttggagttaa gtcaagtgct
    34681 gtagcaacta cttcaatact agatactttt aatatattga gtagtgctgg tgtggtagta
    34741 gtgagtggtg caggaaatca agggaataca gatattcatt attctggcag atttagcagt
    34801 gtgggagaag ttcaagatgt aataatacaa gatggagatg actatgctct tgatataaca
    34861 ctaaatacga atggtccaga taaagtggga gcacagataa tatctccttc aggtgaagtt
    34921 agtcatgata taaggtattc tccagacttt tatatatata gaggaaaatt taacttagaa
    34981 aatactactt atgcaatgag atttatttat ccatatatta cctctggaaa agaaaatttg
    35041 gagataagat taagagatat aaaacctgga gtatggattt taagattgac ttcagaactt
    35101 ataataaatg gagaatatga catatacttg ccaaataaaa atttgatagc tccagacaca
    35161 aggtttttag accctgattc agtagctact ataactatgt atgctgctag tgatgatgta
    35221 attacagttg gtacatttaa caataagact gatagtatgt ggattggttc ttcgaaagga
    35281 ccaattagag gaagaggaat taagccagat atagtagctt caggtgtaga tataatatcc
    35341 acatataaaa atggaacata taatacagga acaggaacag gagtgagcag ttctatagtc
    35401 acaggtgttt tagccttatt gatggaatac ttagaaaaac aggataatgt accgagatta
    35461 tcattgttta cacaagtttt aaaaacatat ttaatattgg gtgctacaaa acttgagata
    35521 tatacatatc caaatgtatc gcagggatat gggattttaa atttaaaaaa tacgattcaa
    35581 cagatagcaa atactctata gataagaacc tatgtaaaat tataattgat tattagttta
    35641 attgtatcaa atactttaga tagagtagaa aaatagcata aaaaataaat atgaaaatta
    35701 aaaaacagtt ttatattttg aatacacaaa gtaaatattt tgtatataaa taggtataaa
    35761 ttaagtattg aaaagatatg atgttaattt aaaaataatt ataatttaga cttatgaatt
    35821 ttatttgtaa aattgctaaa actattacaa aataaataat agaggtgata gttttggaaa
    35881 gtaaaaaggc aagagcatta aaaggtaaag ataataaaag acttaaaagt tcacttttag
    35941 ttggaaatga gtcgacagca gcatgggctg atgttgaaaa attaaaacct catagtaaag
    36001 tttcaatacc ttcaattaag ggtgtcgaag aagcaaaaga ctgggttgac aatggaagta
    36061 aattataaaa ttttggaaat tgaagtaata aagaagtaat gaagataagt atttattatc
    36121 attatgtaag gtagaattat tatattttaa ataacaatca gtatcaatta tataaattta
    36181 ttgactaaaa atttataaat tggtataatt ttgttaatta gcagaaataa taaaagataa
    36241 atactgtgaa gagaagagta gatataaaat gtagttctag cgagttgagg atggtgaaag
    36301 ctcaatacga ggtttatatt gaagaacatc ttggagtttc taatcgaaag cttatttagt
    36361 aagtagactt agacggaagg caccgttata ggctttaagc attgcttaac taagaggtca
    36421 ttatgacaac tagggtggta ccgcgagagt aatagtcttt cgtcccttta tatagggatg
    36481 aagggctttt tttattgaaa ttatatttaa aagaaattaa taacaattat actaggagga
    36541 tttaaaatgc aaaaggaatt tataacagta aaagaattgt acagagaaaa agaacagtac
    36601 atagggaaga ctgtaaaagt agctggatgg ataagaacat ctagagtatc taaaaatttt
    36661 ggatttatag agctaaatga tggaagcttc tttaaaaata tgcagatagt atttgatgag
    36721 aaagtagaaa attttaaaga ggtaggaaaa ttagcaataa gctcatctat acttgtagag
    36781 ggagagttag tatctacaga aggggctaaa caaccagtcg aaatacatgc aaaaagcata
    36841 gttgtagaag gggaatcaga tagttcgtat ccactacaaa agaagagaca tacgcttgaa
    36901 tatttaagaa cgatagcaca tttaagacca agaagtaata ctttttcagc tgtatttaga
    36961 gtaagatcaa tagctgccta tgcaatacac aaattcttcc aagaaagaaa ctttgtatat
    37021 gcacattctc caatcataac aggtagtgac tgtgaaggtg caggagagat gtttagaata
    37081 acaactatgg atttaaatga tattccaaaa actgaagatg gcaaaataga ctatactcaa
    37141 gatttctttg gaaaagaggc taatttaaca gttagtggtc aattaaatgc cgagataatg
    37201 gcactttctt ttagaaacgt ttatactttt ggacctacat ttagagctga aaactcttat
    37261 acaggaagac atgcttcaga attttggatg atagagccag aaatagtttt tgcagacctt
    37321 gaagataaca tggaacttgc agaagatatg ataaaatatg ttataagcta tgtattagaa
    37381 aatgctcctg aagaaatgga attttttaat agttttatag ataaaggatt gttagaaaga
    37441 ttaaataaga tagtaaactc tgagtttatt agaataacgt atactaaagc agtggaatta
    37501 ttaattgaat ctgggcatga atttgagtat cctgttgagt ggggatgtga ccttcaaaca
    37561 gagcatgaaa gatatataac ggagcaaata tataattgtc cagtgtttgt tacagattat
    37621 ccaaaagata taaaagcttt ctatatgaga atgaatgaag atggtaaaac tgttagagca
    37681 atggatttac tagttcctgg agttggagaa atcgtaggag gttctcaaag agaagaaaga
    37741 gaagatgtat tgttagatag aattaatgaa atgggattaa gagaagaaga ttattggtgg
    37801 tatttagaac ttagaaagtt tggtactgct actcactctg gatttggtct tggatttgaa
    37861 agaataatta tgtatatgac aggtatgtct aacataagag acgttatacc tttcccaaga
    37921 actcctaaaa atgctgaatt ttaataatta tatataataa aacttatata actttaagta
    37981 taaacactaa aatgacttgc atatttatct attttagaga tatgcaagtt atttttattg
    38041 tactataaat atataatttg attactttta ttttgcgata taatacttat aggtttatgt
    38101 aatagtatgt aaccttttaa taaaatgcaa cacaattacg tccttgttct tttgcagtat
    38161 atagggcctt atcacaatta cttataaact catttaatgt tattgtcttt ccaattttct
    38221 ttgtataaac tccaatacta acagttacac attttaaagg aacatcatca cgctcaaaat
    38281 tgcaggactc tataattttt cgtaaacatt ctgatttaag tttagcatct gcctcattac
    38341 agttaaaaat acatataaaa aattcctcac caccatatcg tatagcatgt tcattttcag
    38401 aacttgtaaa atctaaaatt actttggcaa tattttgtag acaatagtct cccttttgat
    38461 gtccataatt atcattaaat tgtttaaaat aatctatatc tatcatcatt ccagttatag
    38521 gttcttgatt tgcatggctg attaattttt tttgtagaat atcttcaagg tatctacggt
    38581 tgttcatttt agtaaggtca tctgtcataa ctttgtcgtt aagtaaatta tttatatgag
    38641 atatttcttc atattgttga ctaattaaaa gtttatcata gtaagtaaat acacgatttc
    38701 tatatagcat tgtagaaaca aaaatggcaa gggatgttat aaaaaatgtg ttgacaatat
    38761 tactaaactc attgcctggt atagtttgaa tcccaggtaa gaataaatta agaaacaaaa
    38821 agcatcctcc aaaaactatt actgattctc caaattttaa tactgagaaa gctgcagctg
    38881 ctaacataat ataactaaat acacttaggt catttccacc taactggtca agtagagtaa
    38941 ttacacaacc ccataggcag aaaaaagtca cataaattat ccataaattt atataaaacg
    39001 tacagcaatc ctttttttta ttccaaaggt aagaaaatac aaacataaag acagaagata
    39061 cacaaaatag tgttacatac atataaaaat accattggcg tcttggtgtg acaaaagggc
    39121 ctccttctct agctgagatt gatatcatca taattatttg agatattact attattatgc
    39181 aaatgatttt acccgtatga taaagataat tgcagagttc tttctcaaca ttgtctttgt
    39241 gttttttgtc tagaggaaat ccaaaaaatt tttttatttt ttctaagttc atataagcct
    39301 ccattaaaaa taaagcataa aaataagtat tcctttctat cattagatat ttggaatact
    39361 tcgtttatga tttaattata tcaaaatata ttgtgtgtaa caatctaaaa ttgtgataga
    39421 taaaatttat tagataatgt cgagtaactt tattgattaa tactttatta taattaagat
    39481 ttacagatag tttactactg aaaataaaga atagaataaa tttaaattaa gcataataaa
    39541 atataaataa taaagttcgc attaacaaac tatttaaata tcaagaactg ttaaaaaaca
    39601 acagcaataa acaaataaaa tagataaata tatccaatta aggtataatt aagttttata
    39661 tgatatagtt atatttgata atttacaata gtaaaacttg gagggaaaaa atgggtgaaa
    39721 agaaaataaa taatatgaat tattcacata ataattattc caaaaagaca ggtgaaccaa
    39781 ctagaaaaat aaaaaatagc catatcactc ttaaaagtaa agaagaaaaa atttgttcta
    39841 gttgcaataa agaaaataat actaaggata attactgtaa attttgtgga aatgaacttt
    39901 atgaaatagc atcattaaga ccacttgaaa caaaactaga cttgaaatct aaaataaaag
    39961 agctttcata tcatgcaaat aaaagaggtg tatttttaac aacatttaca accatattta
    40021 tattgtttat tattgcattg atatttaaag ctattataac tattcaattt aatgatatta
    40081 gttatttagt aaatccagca catataatcc tagctctcaa cttgggtcaa attagtgtat
    40141 ctatgtctac catgatgggt tctgggttta taaatgccaa tataggtttg ttgatattac
    40201 ttataatccc tattttggta ttattaatat caaacctaat ttttatgaga aaaagatgta
    40261 gagattcaaa aactgtatta gcaaattctc taggagttgg aattttttat ggattagttt
    40321 tagctatttt atctattttt actaatgtaa aaactagttc acatagtatg ttagaatatg
    40381 gatatgcatt agaatatagt tatgaatttt ttagtgttct tttaaatgga ttcgtattag
    40441 ggtttatatg tacatacata actacttata aaaaaagtta tgaaaaagaa aatatgtatt
    40501 tatctctttt ttcaaattct ataagaacat tcatattagg ttatgtttta gtattagtaa
    40561 tactattggt actaactata tctgatagta gttacttaaa tgaactagat atgagtagtt
    40621 attcaaatgg attaaattta tttactatac tcccacaaat agctagttat atgtgggctt
    40681 ttgcaaatgg aatttcagta accataataa actcaacagt atcaatgttt actttaagtt
    40741 cttcatcttt atttggagat actaaattaa tgttttatgc aatgggagca ttgtctatgt
    40801 taatattatt attaaatgga tacaagctaa gatttaagta taatacagat agtataagac
    40861 ctataatagt atttagtata tattatgcat ttttgatggg aatattggct ttatttagta
    40921 catttatact agatagtaat attaatttct ttaatacaac taattatgga acaactttaa
    40981 taatgcaatt taaagtctta caagctattg tgatttcatt tgtatatagt tttgtgatat
    41041 ctttaatagg atataagcta aattcagctg attaaatatg attggaggga atttctgtgg
    41101 aaggaaatac taataataaa gtagatgata aattttctaa ggttaagaaa aagtttggta
    41161 gtggaaaatt taaagttgaa ttatataaag aaaaatcaaa attaaataga gagattgatg
    41221 atattcaaga agagaaagca aagatattct tggaaatggg aatactgaca tatcaaaaaa
    41281 ttagagaaga ttctattaat gataatagtt ttgataaatt atgtgatgag ttactagaac
    41341 ttgataagtt aatttatgaa aaaaatatgg aaattaatga aatggaaatg gcagaaagta
    41401 atgtaacttg tgagtgtggt tatgttggaa atgtaaatga taaatattgt gctgaatgtg
    41461 gtaaaaaatt tgaattggaa aatgaatgtg atgattttat aatttgtggt tattgtgaaa
    41521 gtgagataga tacagaggct gaattttgtc catgctgtgg aagaaaaatt ataatagatt
    41581 tagaataata ttgggaaacc tatgtatagt atacatgggt ttttttattg aaattattta
    41641 aatggactta taacagtagt tatataaaat gaaaataaac accgaaaaaa tgaaataaaa
    41701 tttcttttaa atgtaaaaaa caagctaata tataaaataa atcagtaaaa atatagatgt
    41761 gagaaaaaaa tatgaaaaaa tattgcaaag aaaaagtttt catgttatta ttaatacata
    41821 aatcaagaaa ataaatttca gaaacgaggt aatttaaaaa atgctagata aggtaaaggg
    41881 aagattaata gtatcatgcc aagctttaga agatgaacct cttcatagtc cttttataat
    41941 ggggagaatg gctaaggctg ctatggaagg tggagctgtt ggaattagag ctcaaggagt
    42001 tgaagatatt attgaaataa aaaaagttac tggacttcct gttataggta ttataaagag
    42061 aaactatgaa gattcagata tatatataac gccaactaaa aaagaagttg atgaactttt
    42121 aacaacaggg tgtgaaatga tagcattaga tgctaccaat agagttagac caaataatga
    42181 agacttaaaa gaacttataa agtatataaa agaaaacggt gttctagtaa tggcagatat
    42241 ttcaaattat gatgaggcta tcaaagcaca agagtacggt gtagattgcg tttcaactac
    42301 actatctgga tatactccat atactaaaac attagaaggt ccagattttg tattaatgga
    42361 aagattagtt aaagatttag aaatacctgt aatagctgaa ggaaaggtaa atactcctca
    42421 agatttaaaa aaggtctttg agttgggtgt tcattcatca gtagtaggtt cagcaataac
    42481 aagaccacaa ttaataacag aaaaatttgt taaagcaatt gaaattaatt aaaaattaat
    42541 ttataaatta aaaaattatt atatttaact atatttgaaa attaaaattg gaggtaaaga
    42601 tatgagaaca acagatatga agggaattta ttcagcatta ttagtttcat ttgataagga
    42661 aggaaatata aatgaaaaag ggttaagaca aataattaga cacaatatag atgtttgtaa
    42721 agtagatggt ctttatgtag gaggaagtac aggggaaaac ttcatgcttt caactgatga
    42781 aaagaaaaga atatttgaaa tagctaaaga tgaagtgaaa gaagaaataa aattaatagc
    42841 tcaagttggt tcagttaatt taaaagaagc tgtagaactt gctaaattta caactgattt
    42901 aggatatgat gcaataagtg ctgttacacc tttttactat aaatttgatt ttgaagaaat
    42961 aaaacactat tataatacaa taataaattc tgtagataat agattaataa tatactctat
    43021 accattttta actggtgttg atatgagttt agaccagttt ggagaattat ttgaaaatga
    43081 aaaaataata ggtgttaagt ttacagcagc agatttctac ttattagaga gaatgagaaa
    43141 aacattccca aataaattaa tatttgcagg atttgatgaa atgatgttac cagctacagt
    43201 tttaggtgta gatggggcaa ttggttctac attcaatgta aacggtgtca gagctagaca
    43261 aatattcgaa ttaactaaga atgaaaaaat atcagaagca cttgaagtac aacatgtgac
    43321 taatgattta ataacagata tattaggaaa tggcttatat caaacaatta aattactact
    43381 tgaagaacaa ggtgttgagg ctggatactg tagacaacct atgaaagaag caactgatga
    43441 aatgaaatca agagcaaaag aaatatacag aaagtatttt taataaaata cttttagtat
    43501 gggaggatta gtcgaatggt aggatttact tggatagatt ttgcaatact agtggtttac
    43561 ttattggcag ttttatttgc aggattgtta ttttcaaaaa aggaaatgaa gggaaaagag
    43621 ttcttcaaag gtgatggaac tattccgtgg tgggttacat cagtatcaat atttgccaca
    43681 ttattaagtc caatatcatt tttatcatta gcaggaaatt cttatggtgg tacttggatt
    43741 ttgtggtttg cacaattagg tatgtttata gcaatacctt tgacaataaa atttttctta
    43801 cctctatata gtaggttaga aatagataca gcatatgaat acttagaaat gagatacgaa
    43861 agtaaaggtc ttagagtact tggagctttg atgtttataa tatatcaaat aggacgtatg
    43921 tctattataa tgtatcttcc atcaatagtt ctggctggtc ttacaggaat acctgtaaat
    43981 gtactgataa tagttatggg tgtaatagca ataatttact catatacagg tggattaaag
    44041 gctgtcttgt ggaccgattt tatacaagga atggtattaa tagtaggtgt tacagggaca
    44101 ttgttctatt taatagcaag tataaatggt ggttttggaa cagtaatgga tactcttaca
    44161 actggacaca agttcttagc aagtaatgaa gttatgtttg ataaaaatat actatctaca
    44221 agtgcattta taatatttgt tggagctggt cttaatactt tttcatcata tgtatcgagt
    44281 caagatatag ttcaaaggtt tactacaaca actgatataa agcaacttaa taaaatgaca
    44341 tatggaaatg gtgttttatc aatgggactt gcaacagtat tttatctaat tggaacttgt
    44401 ttatttatat actatactca aaacccagat ttagctcaaa cagttcaaca agaccaagta
    44461 tttgcatcat atatagctta tgaattacca gtgggtataa caggaatact acttgcagcg
    44521 atatatgcag cttctcaatc aactttatcg acagggctta attcagttgc tacaagttgg
    44581 actttagata tacaaactat cataacaaaa gatataagta tggaaaagca aactaagata
    44641 gcacaatata tatcattagg tgtaggtata ctttctatag ctgttgcaat agtattagca
    44701 aatggagaaa taaagtcagc atatgaatgg tttaatagtt ttatggggct agtactaggt
    44761 gttttagcag gaatatttgt acttggtgca ttttgtaaaa aagcaactaa aatgggagca
    44821 tatgttggat tcatagtatc agcaatttta gttgtttatt taaaataccg tatgccagaa
    44881 gtaacttctt gggcatattc tctaataaca atcacgactt ctgtagtggt aggtacaata
    44941 gttagtgcaa tagaagctaa agttaaagca aaagtatctt taccaaaagc tgagactact
    45001 gtttattatg aaaaataata tttaaatgag aaattgtctt atagagtgat tagataaata
    45061 atttagttac tctataagat tgtataatat actttgtata caaaagtata aaaatagact
    45121 ttataattat atagggagat agtgcttatg atatttggaa atataaatca tagtaagaca
    45181 tattcaacat tgcatgaaga tttacttaga tgttttgaat atgctaaaga taattcatta
    45241 atagattatg aaaaaggtac ttatacaata gatggtgatg atatttttgt gaatattgta
    45301 gagtataaaa cttgtgaaaa agaagataga ttctgggaag ctcataagaa gtatatagat
    45361 gttcatttga tgcttgatgg atgtgaacga atagatataa attttataga aaatttagaa
    45421 caaaaaatat atgaagaaaa gggcgatttc ttgcctcttg atggtaaaaa taatggatac
    45481 atggaactta gaaaaggtga ttttttagtt tgttatccag aagatgctca tatgacagga
    45541 ataaaagttt tagaaaaaga aaatatcaaa aaagctattt ttaaggtttt ggttagataa
    45601 tgataattta tataaccact agggctgaaa atagtgattt aactttcagc gattagtgag
    45661 acttcgtaaa ttttagttag attactattt tcagccttag ttttttatga gaaaattgaa
    45721 aataattaaa agcttaaaat tttgtaaagg agttaactta tggaaaatat agatgtattc
    45781 ttattaatag gacaaagcaa tgctagagga ttgggaaatc caaaagagag catcattcca
    45841 aatgaaaatt gttttgaata tttgagtact gatgaaatta taaatatgag atgtgagcta
    45901 gagacttcag aaggtgatgg tactatagca cctgcatttt caaatgaatg gaataagctt
    45961 actggaaata aagtttgttt tattcacaat gcaaaagatg gttcaagaat aaaaaactgg
    46021 aatcatgata ataactggtt tctaaatgac actatagaaa aatttaatac aggctgtact
    46081 accttaagta aacattataa tatagaaaat aaatacgtta tttggattca aggtgaaagt
    46141 gatgcaaaat atggtagtga tgtattgtac tataaagaaa gtctaaaaaa aattgcgtat
    46201 aggcttaaag aagaatgtat gattgataaa atgtttgtaa gtttaactgg ttattggctt
    46261 ggagaagatg aatattttat tagaacaaga cgaattgcag cagcacagga gtcggcttgt
    46321 agtgaatgtg atatattatg tgtaggaagc aaaattgcta tgcagtttca tgacagagga
    46381 ttaactattg atgatgttca ttacactcaa gaaggtctta atatgttagg agaggactta
    46441 tgtaaaaata tttataagta tcatataacc aaagaaaaaa gtgtattaag tgatactata
    46501 gacttatcag aagcaaggaa atatatctgt gaattggaaa agataagtaa aagatttgtg
    46561 taatataaaa ttttaaatag agttgttaat ttataaaaat aatttgtatg gagatatgtt
    46621 atgaaaaatt acgtttgtat agatgttgga ggtacttcaa taaaatatgg ttttattaga
    46681 gaagatggat ttataattga taaatcaagt cttgatactg aagcaaagga aaaaggtgga
    46741 gaaggaatat tagccaaaat aaaagatata gtaaaaaaat atatagagga aaatgaaata
    46801 agtggtatat gtatatcaac tgcaggtatg gttgacccag ttgaaggtaa aatactattt
    46861 gcattagaag aattaattcc aaactataag ggcatgcaat taaaaaaaga agtagaaaaa
    46921 gagtttaata taaaatgtga agttgaaaat gatgttaatt gtgctggact tggtgaaatg
    46981 tggcttggag caggtagagg tgcaacatct tctatatgtt taacaatagg tactggaatt
    47041 ggtggatgta ttataataaa taataaactg ataaatgggt ttagtaatag tgctggtgaa
    47101 gtaggatata tgaatgtaaa tggaagttct tttcaagaat tggcatctac tagcagtcta
    47161 attaaaaaag tagcaaaaat aaaaaatttg aatgaaaatg acttaaatgg aaaaataatt
    47221 tttgatttag caaagaataa tgatgaagat tgtttaaaag aactcgataa tatgataaaa
    47281 tcattagcag ttggaatcgc aaatatatgt tatgtaataa atccagaagt ggtaatttta
    47341 ggtggtggga ttatggcaca agaaaagttc ctaaaaccaa aaatagacaa agcattaaag
    47401 gaggttctta tagagagagt ttacaaaaac actaatatag aatttgcaaa gagacaaaat
    47461 gatgcaggaa tgcttggagc attatataat tttttaaaca aaatataaag aatagaaggg
    47521 tttttaatga gtattttaga acaattggaa tcaccaactt ttaaagtcac aaaatcagat
    47581 aaattattaa tagcttatat aaaagaaaat atagatgatg tattttataa accaatatca
    47641 caaatagcta aagagagcaa tattggtgaa gcaactataa ctaggtttgt aaaaaaaatg
    47701 aattttaatg gattacagga ttttaaagtt actttagcac aagaaatatc aactatcaat
    47761 aaaaaaaata ttataaataa aaatatacaa aatgatgagc cagctttgga tacagcaaaa
    47821 aaacttttaa gttcaaatgt aaccacttta gagaacacag tagagataat caatagtaag
    47881 gatgtacatg actgcgcaag gcttataata aatgcaaaga aagtttactt cataggtatt
    47941 ggatattctg gtataatagc acaggattca aactataaat ttatgagaat aggtcttaat
    48001 tgtgtaagtt ttgacagtag tcatacaatg ataatgatgt cttccataat ggaagaagga
    48061 gatttaataa ttgcaatttc acattctggt gaaacagaag agattataaa aactgtaaag
    48121 cttgcaagag ccaataatgc taaaattata tcaattactg aaaataaaaa ttctgaatta
    48181 aaggatattt cagatgtaca cttatcttat gtatcgggag aaacagtact ggaaaccggt
    48241 tcaatatctt ctaaattagc acaatttttc attattgatt tagtatatac acaggtagta
    48301 aaagaacttt ctaatgaagc tattgaaagg aaaattaaaa ctacaaatgc tataaaattg
    48361 tttaaaaatg aataaaataa gaaatttgta atgttttata gagctctctt aaaaatttag
    48421 gaatggagag atattacatg tctaaattaa aagattataa tattgataaa gtaataattt
    48481 ttaataattt aagtactaaa acgaagaatc aacttaaaga aaaagttaaa ctaaaaagat
    48541 tacaaaaaaa agaaatttta ttttatgaaa aagatagctt agacagtgtt tatatacttt
    48601 tagaaggaaa ggtatctatt tttaagataa gtgaaaatgg agagagaaaa gtaattttca
    48661 tattaaatag tggggaagtc ataaatgata ttacacttga cgcttctaaa aactctactg
    48721 ttggctgtga agcatttgaa aattcaattg tagcttatta tagtattgaa gaatttttag
    48781 aaattatgca aaatgatttt caacttacaa aggatattat ttcttatatg gaaagaagaa
    48841 taagacgttt atatagacag ttgaaaaatt ctatatccat aaaagtagat aaaaaacttg
    48901 cagcaaaatt atataggtta agtagagaat ttggagtttg ctgtggagaa tggactttac
    48961 taaatgtaaa tattacagtt acatatttag ctgatatgct tggctgtaaa agggagactg
    49021 tttccagaat gataaaggta ttgcaaaaag aagaacttat taaaattgac aataaaggtt
    49081 tttatgttaa agaaactgaa ttatcaaggt attttaaaaa taattaatta tgattaagta
    49141 agagtattat tagaatttta attaaataaa aatattatta agagaatcta tttatagatt
    49201 cttttttatt gtctaattta ttaattttta ttttacccta ttgaattgta taaaaaaaca
    49261 aataagattc ttttttattc aaaaaattga gtagatagta gttttattgt acttaatgat
    49321 tgtatttaag tgattagatt tgaaattgaa taatgtagat aataaaaaaa tattaacaga
    49381 acttaataaa ctccattaat atttttttta ttatttttga aactgtgata attatcacgg
    49441 aagcatagaa aataaagtgt taagatttaa acaagatagc aagtaagtaa aactaaaata
    49501 taagaaaggt gataaaaatg aaactaaaat tagattcatc taagttcaat gaaggtctga
    49561 attatctaaa aaaagactac aagatatttg caccagtttt aatcccattt aaaggtactt
    49621 tttcagatac tgatgttata agatacaagg aggtaaacgc ttttgaagaa atggaatttg
    49681 ctaagaaagc aaacttttca ccaaaagaag ttgtacttcc cataaatcaa gtattgtttt
    49741 attttactga aaaagagttt aaggaaagcg atttagacaa caagaaaatt ttaattttct
    49801 taagagcttg tgacataaat ggtataaaaa gacttgatga aatatatcta aataatggtg
    49861 aagaaaaaga ttatttttat aaaaatatca gagataaagt aaagtttgca cttgtagggt
    49921 gtaaggaaag ttttagaaac tgtttttgtg tgagcatgga ttctaacaaa actgataatt
    49981 attcaattgg attaaatata gaaggagata cactgtactt agatataaag gatagtgaat
    50041 ttgaagtatt taatggagaa gcaactgaat ttaatgttga ttatgtaact gataatttaa
    50101 tatctgtaga tgtgccagag aatattgatt caaatgaaat gataggaaat tcaatatggg
    50161 atgaatatga tacaagatgt ataggatgtg gtagatgtaa ttttgtatgt ccaacatgtt
    50221 catgttttac aatgcaggat attttctata aggaaaacga aaatgtaggt gagagaagaa
    50281 gggtttgggc ttcttgtcaa gtagatggat atacagatat agcaggtgga aattctttta
    50341 gaaaaaaaca aggtgaaaga atgagattta aaactatgca taaaatacat gattttaaaa
    50401 aaagattcgg atatcatatg tgtgttggtt gtggaagatg tgatgatgcc tgtccgcaat
    50461 acatatcatt ttcaaagtgt atagaaaaaa taaatgattt agtaattagt aaggaggaag
    50521 tataaatgaa cccatatata ccagtaagtg caaaaatact agatatagtt aaacatactg
    50581 ataaagaatg gacttttaga gtaaactgca atacaaaagg tgtattgcct ggaaagtttt
    50641 atgagatatc tatacctaaa tacggtgaaa gtccaatatc agtatcagga tatggagagg
    50701 attatattga ctttacaata agaaatgtag gaaaagtaac tagcgagttg tttaattata
    50761 aagaaggaga ttcttttttt ataagaggtc cttatggaaa tggatttgat gtatcccttt
    50821 atgaaggaag agaaattgta gtagtggcag gaggaagtgc attagcccct gtaagaggaa
    50881 tagttgaata tttttataat aataaagaaa aatgcgaaaa gtttaaatta atagtaggat
    50941 ttaaatcacc aaaagatatt ttatttgcag atgatttaaa gagatggagt aaaaaacttg
    51001 atattttagt tactgtagat ggagcagagg aaggatatag tggtaatgta ggattagtaa
    51061 caaaatacat accagaattg gatatgaaag atataaacaa tacttctata gttgtagttg
    51121 gacctccaat gatgatgaaa tttacagtag aagaattttt aaaaagagat ttagatgaaa
    51181 agaacatttg ggtttcttat gaaagaaaaa tgtgttgtgg aataggtaaa tgtggacatt
    51241 gtaaaatgga tgatacttac atatgtttag atggaccagt atttgattat tcatatgcta
    51301 aaaatcttat tgattagggg gtgaagtttg tgataagaga tttaaatacc aaaaaagtaa
    51361 tgaaaaatgc ttatagaatt acaaaaacaa aatatgagac ttctttaaga gttagagtac
    51421 ctggaggtct tattgaccct gagagtttag ctgtagtttc taaaattgca agtgagtacg
    51481 gcaatggaca ggtgcacata actacaagac aggggtttga aatattagga ataaatatgg
    51541 aagatatgga agaaataaat aaaattatac aacctgttat tgaaaaaatg aatataaatc
    51601 aaagtgagaa aaacgcaggt tatccagcag caggtacaag aaatatagca gcttgtatag
    51661 gaaataaagt ctgtccaaag gctcaatata atacaactga atttgctaaa agaatagaaa
    51721 aagctatatt tccaaatgat ttacatttta aagtggcttt aactggttgt ccaaatgatt
    51781 gtataaaagc tagaatgaat gactttggaa ttattggtat ggctttacca atatatgaaa
    51841 aggatagatg tgtaaattgt ggagcatgtg taaaaaaatg ttctaagata tctgttggag
    51901 cattaaaaac agaaaataat aaggtggtaa gagataaaga taagtgtata ggctgtggag
    51961 agtgtgtact aaattgccca acaaatgcat ggactagaga tgagaaaaaa tactatagat
    52021 tagctataat gggtagaaca ggaaagaaaa accctagact agcagaagat tttcttttat
    52081 gggtagatga ggacagcata ataaagataa tacttaatac ttatagatat gtagaaaagt
    52141 atatagataa agatgcacca ggaggaaaag aacatatagg atatataatt gatagaacag
    52201 gatttatgga atttaaaaaa tgggcacttg aaggtgtaga gcttccagaa ataactaaaa
    52261 tgtacgaaaa catatactgg agtggaatta aatatctata aattgagtaa aacatatatt
    52321 tgaataaatt aaaatttaat agaaggaaga gggagttatg cataaagaaa ctttggataa
    52381 attaactaat gcagctataa ataagataaa tttattaaac acaagtaaag taaaatattt
    52441 ggtatcttct gcgtttgcag gactttatgt aggtataggt atacttttga tatttactat
    52501 tggaggactt ttgactgatg caggttcacc tatgactaag atagtaatgg ggttatcatt
    52561 tgcaatagca ctaagtttgg ttataatgac gggaacagag ttatttactg gaaacaatat
    52621 ggttatgtct gctggtatgt taaataaagg tgtaagtata aaagatactt ctaaaatatg
    52681 ggcatacagt tgggtaggta atttaatcgg agctttggtt ttaggcatta tatttgtagg
    52741 aactggtcta gtagacaaag gacctgtagc tgaatttttt gcaaatacag cagctagtaa
    52801 agcatccatg ccatttacag ctcttttctt tagagggatt ttatgtaata ttctagtatg
    52861 tgtatcagtg ttgtgttcgt ttagaactaa tagtgatact gcaaaaataa ttatgatatt
    52921 cttatgttta tttgctttta taacatcagg ttttgagcat agtgtagcaa atatgacaat
    52981 ttatagtgtt tcattatttt caccaacaat aagtacagtt actattggag gagctattta
    53041 taatttagta gctgtaacac ttggaaatat tgttggagga gctttattta tgggtcttgg
    53101 aacttatata ttaggtaaag aaaagcttaa ttaaatttat tgtataaatt ataactctct
    53161 tgataaatac atttttagta ttgttgagag agttattttt atatttttga aaaaatattt
    53221 gaaacaaaaa aaatatggga gcatacgaaa atatatcggt tatatatata aaaaatacgt
    53281 ttatatatga attatatagt tctaaatata aaaaaagtta aagtcctacc gtaaaaaagc
    53341 gcattttgaa taagataaca aatatgataa aattggtctt gttgaaattt ttagggggga
    53401 tatgatgaca aagaaactag taatatcaaa aacaaagttg tttattttta taatagcatt
    53461 tatttctata tttatatatt tatttggaag taaaaataca cttataggtg taggtatagt
    53521 aacagctatg ctaacactct tggaaagaga tttaactatt tctccaatta aaaatttact
    53581 gaagtattta gcaataaata taatcttagg aatactatca ttttttgcag tacaaaatat
    53641 gtatttagga gttttattaa attttatagc attatttata atagggtatg tatttagtta
    53701 tgacttaaaa agagcagtat atgtaccctt tggtctaatg tatatattta tggtaagtat
    53761 acctgtagga aaaagtgaat ttcctatgag attgtcggct ttagctgttg gagcagttat
    53821 aataatgatt gctcaatttg ttatgaatag aaataggatg aaaaatgtcg gagataaaga
    53881 actgatatct atatgtgatg aattattaga aaaaattagt cttttaaaaa atactattaa
    53941 tgatgatagt tctataatta aatctagtat gagaaaaata gatagctgta attatagaat
    54001 aaattctata tctaaaaatt tgaaaatggt tatttttgat aatagaaaag atgactttta
    54061 tatcagtatt agaggtatag acataatgaa tattttattt tcattagaaa gaataagttt
    54121 aatcctggaa agatacaaaa aggatagtaa agaatttgaa gatgaagata taaaaaatat
    54181 tttagaagaa agtagcataa atagtaaatc agatgtttta gttgtagcaa cgaaagaaat
    54241 aaactatatt aagatgtgtt tagaaaataa agataccata actgataaag agatattagg
    54301 atttagagat tatgttattt ctcaggatac taaaaatata aatttaaaag aaatttatag
    54361 tgttttagaa aatttatatg agtttttagt agattataaa aaagtaaaat caagagacga
    54421 aaagaaagct gaaagaaaat caaagatacc tcatgaattt aaacgactat caatatataa
    54481 gaaaaacttt aatttaaatt ctataagatt ttcttatgca gtaaagattg ctttagctac
    54541 agctgtagcg ggttttatta tggattattt ccatttaaga gatggaagat ggataatgtt
    54601 aactgtcttt tcattaacac aaccttacgc agaaaattgt atacaaaggt ctagaaaaag
    54661 aatagaaggt acatttatag gagctgtaat atttattgta ttattttcaa taataaaaga
    54721 tagtacatta aggtcgttaa tagttctttt agcagggtat ataaactctt atgtagttga
    54781 ttatagaaaa ttaatggtat gtgtaactgt ttcagctctt ggttcagcag tagttatggg
    54841 agacccaaat gttttaacaa taagcaggat ttcatatgta gcattaggag caattattgc
    54901 attaatagta aataagttta tattaccata tgatgctaaa acaggctatc aacatgttat
    54961 agaaatgtat aaaggaatag ttaaaaatat aattgatgaa gtcaataagt ctatagaaaa
    55021 tgtagctgat gtttactata taaaaaattt attattgata ccatcactta ttgaagatag
    55081 acttatgttg ataaatgcta tatataaaga taaacatcaa gaggattttt tagaaaatca
    55141 gaaattacta ataagtaata tgtataatct atatataaat gttaataaaa ataaaataaa
    55201 agatgaagat gttgaaaaaa tattgagaga taccaattat atttcaaatt acaatgtaga
    55261 taagtatgat gaaggaagaa gtgtaatttt agagagtatt gtaaatacta aaagtctagg
    55321 tgacaagata atatgtctaa acttactgca aactctaaat ggtgtcaaag aaatgtatag
    55381 aataagtaat ataactaaag tttcaataaa agaagcagct tagatattaa attatagaat
    55441 agccatatat ttaaaataaa gtatatggct atttgtttta taaaatacta aaagaaaata
    55501 atatataaaa aacaaaaaca tatatttatg aattttatat gaaaatagtt aaaatattga
    55561 tttttttcat tggttgaaaa aacaatttac ttaggataaa ctataatagt attcaaatat
    55621 tatgggggtt agatttatga gtaaagatgt aaaggtaaag cgtaataaga aatatgatac
    55681 atttagtata actatggaac ttgagagacc tttactttat gatgaggttg agaacaaaga
    55741 tgataaaaat aataatagaa aatttaacat aaagaataag atatttaagg gaataggtat
    55801 actatttgta ttgattttgc ttggcttttt catatggata aataaaacat atgaacctca
    55861 aaagctggca aaagaagctc tagtcagcaa tagtaaagtt gaagtaactg taaatgaaaa
    55921 catttcattt acaccaaaag gaagaaaagt ttctaaaggt ttaattttgt atccaggagc
    55981 taaagtagaa atagaatctt atgctccact tgcaagaaaa atagcagaaa gtggatatga
    56041 ggttgtaatc gtaaagatgc cacttaatct agctatactt ggaactaata aggcacagaa
    56101 agttatggat tcttacaaca acatagaaca ttgggtaata ggaggtcatt cattaggagg
    56161 agttgcagca tcaaattttg cacgtgataa taaattaatt gaaggcgttg tatttttagc
    56221 ttcttatcca atgggtgatg agttgaaaga attaggaaaa aaagttatat ctatatgggg
    56281 gagcaaagat ggagtagtca attttaaaag tcttgtagaa tcaaaacaaa aacttcctga
    56341 tgatacaact tatgttgaga ttgaaggagg aaatcatgca caatttggag attatggaaa
    56401 acaaaaggga gataatgatg ctattataag tcaagaaaaa caacttaata ttactgccaa
    56461 tagtatcatt aaatttttaa agaatatatc ttaaact
//
LOCUS       DAEQCW010000011        54825 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.011, whole genome shotgun sequence.
ACCESSION   DAEQCW010000011 DAEQCW010000000
VERSION     DAEQCW010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 54825)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54825)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54825
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.011"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            487..1326
                     /locus_tag="KRO40_000738"
     CDS             487..1326
                     /locus_tag="KRO40_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HBH2091571.1"
                     /translation="MLDINSFLNGFFNIILRMSIYDLIDISIVAYIFYKIFMFIKDTR
                     AEQVFKGIIFLLLATQLSNTFKLHTVYWISLKALDYGVIAALIIFQPEFRAGLEHIGR
                     AKFNLFGKNVNTSEETLNRNIEEIVEALYSLSRQKIGALIIMERETRISDIINTGTII
                     DAEISRQLLINIFIPNTPLHDGAVVIRDSKVKAAACFLPLTESKDLSKDLGTRHRAGI
                     GVSEVSDCITLIVSEETGGVSIAKAGKLYRDISRERMMNILRSNLKTNTETRSFFKGG
                     IFK"
     gene            1323..2504
                     /locus_tag="KRO40_000739"
     CDS             1323..2504
                     /locus_tag="KRO40_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091572.1"
                     /translation="MINRLKNNTKIKIISFLSAIALWMYVMAVVDPEETKGFEDIPVS
                     ISNMSDLKDKNLVIYPDEKLTADVYIKGSLSKVQSVKKEDIHVYGTIEDPIQGQKEVY
                     LKANIPQGVTLEFKHDVLVVNLEKNIKEKRDIKVEVSGNSKRNINKIELSKEFVDVSG
                     PRTLVKEVKSVRANLDVGNETDDFSKKLQLIPLNSDGTKVEGVTLSSSFVTAKIELLK
                     EKIVPIRVSLNDNKDNDVLKNYKLSKEQVTIKGKKDDIDKISYIKTKPIDLADLANGE
                     EKEVSLEIPEGITLEDSSITIKLNDTKQLSAEFLYNAGDIELRNIPTNMDNPNVISDV
                     DIKVVVESTEDLSKLNKKDISLYIDLSQGPEEDSKYKIKYETTYQFKKINIEPNIVEV
                     E"
     gene            2808..3710
                     /gene="ptb"
                     /locus_tag="KRO40_000740"
     CDS             2808..3710
                     /gene="ptb"
                     /locus_tag="KRO40_000740"
                     /EC_number="2.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate butyryltransferase"
                     /protein_id="HBH2091573.1"
                     /translation="MRSFEEVIKFAKERGPKTISVACCQDKEVLMAVEMARKEKIANA
                     ILVGDIEKTKEIAKSIDMDIENYELIDIKDLAEASLKSVELVSQGKADMVMKGLVDTS
                     IILKAVLNKEVGLRTGNVLSHVAVFDVEGYDRLFFVTDAAMNLAPDTNTKKQIIENAC
                     TVAHSLDISEPKVAAICAKEKVNPKMKDTVEAKELEEMYERGEIKGCMVGGPFAIDNA
                     VSLEAAKHKGINHPVAGRADILLAPDIEGGNILYKALVFFSKSKNAGVIVGAKAPIIL
                     TSRADSEETKLNSIALGVLMAAKA"
     gene            3732..4811
                     /gene="buk"
                     /locus_tag="KRO40_000741"
     CDS             3732..4811
                     /gene="buk"
                     /locus_tag="KRO40_000741"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH2091574.1"
                     /translation="MSKIFKILTINPGSTSTKIAVFDNEDLVFEKTLRHSSEEIGKYE
                     KVSDQFEFRKQVIEEALKEGGVKTSELDAVVGRGGLLKPIKGGTYSVSAAMIEDLKVG
                     VLGEHASNLGGIIAKQIGEEVNVPSYIVDPVVVDELEDVARISGMPEISRASVVHALN
                     QKAIARRYAREINKKYEDINLIVAHMGGGVSVGAHKNGKIVDVANALDGEGPFSPERS
                     GGLPVGALVKMCFSGKYTQDEIKKKIKGNGGLVAYLNTNDAREVEERIEAGDEKAKLV
                     YEAMAYQISKEIGASAAVLKGDVKAILLTGGIAYSKMFTEMIADRVKFIADVKVYPGE
                     DEMIALAQGGLRVLTGEEEAQVYDN"
     gene            4801..5478
                     /locus_tag="KRO40_000742"
     CDS             4801..5478
                     /locus_tag="KRO40_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2091575.1"
                     /translation="MITNDKRIRIITGHYGSGKSEFAMNYVVKLRDMVSGKVAIADLD
                     VVNVYFRTREKKELMKSLGIQPIDSSINAPTLDLPAVSAEVMSPMVDHSYNSVIDLGG
                     DNVGARVIGRFSHLLKEGDYDMLFVINANREKTQTSEEVIQYIKEIEKSSKLKVTGLI
                     NNTHLIRFTTIDDVLRGQKVAKEVSEKCNIPIRYVACLENLVEQLPKDLEGEIFPIKL
                     YMREDWM"
     gene            5521..5736
                     /locus_tag="KRO40_000743"
     CDS             5521..5736
                     /locus_tag="KRO40_000743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2091576.1"
                     /translation="MAKGKVSFNQERCKGCGLCVEACPVKIIQLDSNVINKKGYNPAT
                     VFEMEKCIGCASCATMCPDVVITVERD"
     gene            5765..6844
                     /locus_tag="KRO40_000744"
     CDS             5765..6844
                     /locus_tag="KRO40_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH2091577.1"
                     /translation="MAKILMKGNEAFGKAAIEAGCKYFFGYPITPQSELPEYLSRELP
                     KIGGAFVQAESEVSAINMVYGGAGAGARVMTSSSSPGVALKQEGITYAVGAEVPCVVL
                     NVMRGGPGLGSIQPSQADYFMSTRGGGNGDYRTPVFAPATVQEAVDMIMEAFDVADYY
                     RSPVMVVADGMIGQMMEPVEFRAPEKKRELPPKDWATVGTKGKRKPNVINSLYLEPEV
                     LEDHCWHLQEKFDAMEKNEVQYEMYKTEDAEFVFAAYGTTSRVVKSAIDILREEGIKA
                     GLIRPKVLWPFPFEAFNQIPNARNILTVEMSMGQMVEDVKMAVEGKLPVYFHGRPGGM
                     TPTPAEIVEKAKKIIAGELVAGGAR"
     gene            6844..7596
                     /locus_tag="KRO40_000745"
     CDS             6844..7596
                     /locus_tag="KRO40_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH2091578.1"
                     /translation="MAVVFKKTEGLQDTQTHYCPGCTHGIIHRLVGEVLEELGVLGDA
                     VGVVPVGCSVLGYKYFNCDTQEAAHGRAPAAATGIKRVHPENTVFTYQGDGDLASIGT
                     AEIVHAAARGEKITTIFVNNTTYGMTGGQMAPTTLVGQRATTAQSGRNAETQGYPIRV
                     SEMLATLTGAVFVERVAVDTPAHVRQAKKAIKKAFQVQQAGLGFGIVEVLSTCPTNWG
                     LAPNDALQWLRDNMIPYYPLGNFKNVEVEEVK"
     gene            7597..8154
                     /locus_tag="KRO40_000746"
     CDS             7597..8154
                     /locus_tag="KRO40_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH2091579.1"
                     /translation="MSTARVICAGFGGQGVMSMGQLLTYAGMLEGKEVSWLPSYGPEM
                     RGGTANCAVTVSNEPVGSPLITDDATAAILLNIPAFEKFKDDVIPGGKIIVNSSLIKE
                     KVDRTDVDVYYIPANELAAELGNDKVANMIMLGAYLKVSDTVDIESVLEAFKKVFGPR
                     KEKFVPLNREALQKGMDATCSKATN"
     gene            8324..9670
                     /locus_tag="KRO40_000747"
     CDS             8324..9670
                     /locus_tag="KRO40_000747"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HBH2091580.1"
                     /translation="MRKYFGTDGVRGVANTELTCDLAYKLGRAGGFVLAQGDHRVKVV
                     VGKDTRISGDMLEASLIAGLMSVGCDVITVGIIPTPAVAYLTRKYGADCGVVISASHN
                     PVEYNGIKFFNKNGYKLDDEIELKIEEYIDDIDKIDCLPIGENVGRKLHEHCAQRDYV
                     DYLKSIISTDFKGLKVVLDCANGASYKVAPIVFDELGASVISINSSPDGNNINYKCGS
                     THPEQLQRAVLEHNADLGLAYDGDADRLIAVNEKGQIVDGDHIMILSALNLKKNNKLA
                     QDTLVVTVMSNIGLTIAAKENGINLSTTAVGDRYVLEDMVKNGYNLGGEQSGHMIFLD
                     YNTTGDGVLSSLILANIILQEKKPLSEIASIMSQYPQVLVNATIKNENKNKYMEYPEI
                     KTEIERIESILDGNGRVLIRPSGTEPLVRVMLEGKEEGQIKELATNLANLIQEKLS"
     gene            9937..11769
                     /gene="glmS"
                     /locus_tag="KRO40_000748"
     CDS             9937..11769
                     /gene="glmS"
                     /locus_tag="KRO40_000748"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003401499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HBH2091581.1"
                     /translation="MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKEL
                     NIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHGEPSDVNSHPHFNQAKTIAVVHN
                     GIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
                     GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKD
                     ENVTVYDSNRNLVEKEVFHVTWDVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDN
                     GNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFVNIPVITDIASEFRY
                     SDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYT
                     WAGPEVAVASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEIL
                     DNEEYIKEVAKTVVSSEHAFYLGRGIDYSLAMEGSLKLKEISYIHAEAFAAGELKHGT
                     IALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAADKIIYI
                     PNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE"
     gene            12221..13516
                     /locus_tag="KRO40_000749"
     CDS             12221..13516
                     /locus_tag="KRO40_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiosulfate sulfurtransferase"
                     /protein_id="HBH2091582.1"
                     /translation="MTNDFKKEKKEDYFVNLKAISTEVLQEKVQDNAWVIVDTRLNDA
                     YNGWKLDGVKRGGHIKGAVDFSANWLSVYSDRKDEVLEQALKTKRIDLDKNIVLYDAN
                     GKDALVVANYLSKKGYKYLYKYDIKQWADDENLPMERYKNYQMIVPAFIIKDILDGKI
                     PETFEDSKNIKMIEASWGKESYTKGHIPTSVHVNTDIIEPPPTWMLDNDDNLTKFALD
                     YGLTKDDTVIVSSSTPMASYRLAVILRYIGVKDVRVLNGGTNSWLSAGYELEFISNPK
                     HSCTNFGADIPVNSQLIVTTSELRQKLKEKNKFILVDNRTWDEHIGKVSGYTYYDKKG
                     RIPGALYGHSGSDSVSLEEYRNIDNTMRNKYEILEMWDKENIDVNKQLIFMCGSGWRA
                     AEVLTYANVIGVENTSLYSDGWMGWSLDNSNLIEVGEHK"
     gene            13944..14681
                     /locus_tag="KRO40_000750"
     CDS             13944..14681
                     /locus_tag="KRO40_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YwmB family TATA-box binding protein"
                     /protein_id="HBH2091583.1"
                     /translation="MKKVKLAISFFILMIIGMTISYADTSINTRYNRLSKALEISEAN
                     FKFYNVKINSVINHNLSNKEFHNIFIEIINNLKLDKKGINWNQKGSGDKIQLCATIKG
                     SDKEISIKGINKNNKESYIVVDILDNKVYKHKEVIYSNVENVLNKYSSQVDVSACIVG
                     EYTKRLQNNKYDDILQKILYNMSAKQIDEVKDVNFLSITAYSKVLNDYELEYLGEKIN
                     LNIGIKYNEDDGKTLIYIATPIIKLDY"
     gene            14702..15955
                     /gene="murA"
                     /locus_tag="KRO40_000751"
     CDS             14702..15955
                     /gene="murA"
                     /locus_tag="KRO40_000751"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HBH2091584.1"
                     /translation="MAKIIVKKSNPLKGSVKIDGAKNAVLPIIAATLLANGKSTLNGV
                     PNLRDVHVISDLLRHVGAEVEYKENTLTVDASNIKTCEAPYELVRKMRASFLVMGPLL
                     ARFNSTKISMPGGCAIGTRPIDLHLKGFKALGAKIEMDHGFVEAATEKLVGNKLYLDF
                     PSVGATENIMMAASLAEGTTIIENAAEEPEIVDLANFLNEMGADVKGAGTNTIKIKGV
                     KELKGAEHNVIPDRIEAATYMVAAAMTKGDITVENVLMEHLKPVVAKLREAGCEITEM
                     DNSVRVVGPKVLKPIDIKTLPHPGFPTDVQAQFMAMLTVANGTGVVIETVFENRFMHV
                     AEFNRMGANIKIDGRSAVVNGVDELHGAAVNATDLRAGAALILCGLIAEGETQIGEIY
                     HIQRGYVDIDKKITALGGQIEIVED"
     gene            16042..17106
                     /gene="spoIID"
                     /locus_tag="KRO40_000752"
     CDS             16042..17106
                     /gene="spoIID"
                     /locus_tag="KRO40_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein D"
                     /protein_id="HBH2091585.1"
                     /translation="MKNPLVVLLGFVTCSVLVPSLITLVSYKNVELTEKPESPVSINK
                     TIKKSDIEDKGNKEEKNTVNYETVNKKAPIINVYNHITGKTEKMDMENYLCGVLAGEM
                     SSEFDIEALKAQSVAARTYVVYKQEHGKSSKHKNAVVCTDYKHCQEYKSYDTLKKLNG
                     EEWIKNKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKS
                     VESPYDKYSPKFASTLKISNTDFVKSLRRAYSTIVIDVNNLSKQVSITKRSDAGTVEK
                     IKLGNKELTGKDIRTVFKLNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEG
                     YKYYDILSHYYTDTKIKDIY"
     gene            17172..17840
                     /locus_tag="KRO40_000753"
     CDS             17172..17840
                     /locus_tag="KRO40_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M23 family metallopeptidase"
                     /protein_id="HBH2091586.1"
                     /translation="MKKKLLEKDGFYLSLFVCVCLLAVGGVWFTNNNVDKLASNKGIM
                     ENANKDSEEEIHLIEKDKKDAIPTATDSKQNLEKAKSKEENKSSTTKLNYIGDKVIRG
                     YSEKEPSYSKTLDVWETHKGVDISCTKGKEVKSLLNGIVVDVFDDEEYGQSVKIKSDN
                     NIVVVYSNLDKNVSVKKEQKVTEGQSLGTVGSTSQIESEEGIHVHLEAYSGEKSIDPM
                     SLIK"
     gene            17938..18198
                     /gene="spoIIID"
                     /locus_tag="KRO40_000754"
     CDS             17938..18198
                     /gene="spoIIID"
                     /locus_tag="KRO40_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcriptional regulator SpoIIID"
                     /protein_id="HBH2091587.1"
                     /translation="MRSHIEERAIVVAKYILEKNTTVRQTAKTFGVSKSTIHKDVTER
                     LKEINPSLAKEVKNVLDKNKSERHIRGGLATKLKYEKEHKKM"
     gene            18395..19414
                     /locus_tag="KRO40_000755"
     CDS             18395..19414
                     /locus_tag="KRO40_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBH2091588.1"
                     /translation="MAGADIGIDLGTANVLVYVSGKGIVLEEPSVVAIDKRTDSVLAV
                     GEEAKKMIGRTPGNIVAIRPLRDGVISDYDVTEKMLKSFIDKIVDKKGFGRFFMPRIM
                     VCVPTGVTEVEKRAVEDATRQAGAREVYIIEEPIAAAIGAGVDISQPNGNMIIDIGGG
                     TVDIAVISLGGAVVSESIKVGGDRFDDAIVKYMKKQHNLLIGERTAEKIKFEIGSAFK
                     REEEKYMKITGRNLITGLPSSITINSTEMLEALRECVEQIVVATHAVLEKTPPELAAD
                     IGDVGIIMTGGGSLLYGLDKIIEQRTGITVTIADEPLSCVAKGTGIALGSIDLLETGG
                     SFKRK"
     gene            19430..19858
                     /gene="fabZ"
                     /locus_tag="KRO40_000756"
     CDS             19430..19858
                     /gene="fabZ"
                     /locus_tag="KRO40_000756"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HBH2091589.1"
                     /translation="MLNIDEIKKLIPHRYPFLLVDKITELEVGKRAVGIKNVTVNEPF
                     FQGHFPEYPLMPGVLIVEALAQVCGVAMMSVEENKGKLGVFAGIDKVRIKREVRPGDT
                     LTMEVEMTTLRKNIAKADAKAYVGEELVCKGELMFALVEK"
     gene            complement(19969..20478)
                     /gene="yyaC"
                     /locus_tag="KRO40_000757"
     CDS             complement(19969..20478)
                     /gene="yyaC"
                     /locus_tag="KRO40_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protease YyaC"
                     /protein_id="HBH2091590.1"
                     /translation="MYLAKVNYSDDDVIQMLSSVLKTIINENTIVVCIGTDRAIGDTL
                     GPLVGTILKNSNFKYPVYGTLDNPIHALNIYESLDTIKNTHIQGNFLAIDACLGSQSN
                     IGNIQIREGPILPGKGVGKKLPQIGNYSIVGIVDKIDENNKLSFNNIRLSFILDLAET
                     IALALLVST"
     regulatory      20667..20770
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            20907..22100
                     /locus_tag="KRO40_000758"
     CDS             20907..22100
                     /locus_tag="KRO40_000758"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HBH2091591.1"
                     /translation="MARHLFTSESVTEGHPDKICDQISDSILDALLEKDPQSRVACET
                     TVTTGLVLVAGEISTSAYVDIPKLVRETVREIGYTRAKYGFDCDTCAVITSIDEQSGD
                     IAMGVDEGLESKTGEEIEEEIEKVGAGDQGIMFGFACNETPELMPLPISLAHKLSRRL
                     TEVRKTGLVDYLRPDGKTQVTVEYEGSKAVRVHTVLISAQHCETVSNDKIREDLINHV
                     IKEVIPAELLDEETKIYINPTGRFVIGGPQGDTGLTGRKIIIDTYGGYSRHGGGAFSG
                     KDPTKVDRSAAYAARYVAKNIVAAGLADKCEIELAYAIGIARPLSIFIDTFGTGKVSE
                     EKLVELVNKHFDLRPGAIIRDLDLRKPLYKKVAAYGHFGRTDIDLPWERTDKVEQLRK
                     DALGE"
     gene            22416..23513
                     /locus_tag="KRO40_000759"
     CDS             22416..23513
                     /locus_tag="KRO40_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091592.1"
                     /translation="MSGKVNIKTVISFAGAYVATVIGSGFATGQEILQFFTFYGYAGI
                     IGGIISMVLFSWFGAEVIDKGRELKLKEPIKIYQVYCGKYLGTFFEWFGPLFLFGTLV
                     IMIAGAGATLSEYYGLNPYVGRIGMAIVSLITVSLGLTRLSKILGNIGPIIIIFTLLV
                     GAISLFSNIDALSNAGNMVDSLNIKTATSNGYFSGVLYTCYNVIIVITFLTGMGASAV
                     NKKDAVWGGIVGGVALMAAAIMMNLALLSDIGNIYTKEIPALYLADKISPIIGILFSV
                     VLLLGIYTTAVPLLWSVTNRFVEDDHPKFKIITIVVSILACIGGLLPFDKLVGTLYPY
                     TGYMGILILLCMLYRRITKTEGYKENKSEIS"
     gene            23777..25996
                     /locus_tag="KRO40_000760"
     CDS             23777..25996
                     /locus_tag="KRO40_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HBH2091593.1"
                     /translation="MEKLEGMISEIVFKNEDNGYTIAHLVNENDEIVVVGCMPTLAIG
                     ESIEVEGKWVNHKIYGTQFEVNSFMPVTPSSLEGIYVYLSSGMIHGIGEKMAKRIIDK
                     FGVDTLEVIQNSPEKLQEVEGIGSKKVKQIVKSYEEDRELRNIIIQLSPFGITPNYCL
                     KIYKKYKSSAIEVINKNPYQLAEDIRGIGFKVADSIASKIGIDKNSKDRICQGILYTL
                     NKSLSNGHTYLPEHVLIQDSEKLLELNGEIIKECVMMLVYNQKIHIEKVNNENLIYLM
                     PYYLAENGVCSQIVKLSQYEFEDLKIDIDNEINVLEEDKKIKLAEKQILAVKESVNSG
                     VLIITGGPGTGKTTTINAIIDIFENNGKSVTLAAPTGRAAKRMSETSNKEAKTIHRLL
                     EMGFSTDDDLTFFKDEEDPINSDVIIVDEVSMVDIILMYNLLRAIKLGTRVILVGDSD
                     QLPSVGAGNVLKDMINSNIINVVKLNEIFRQAQESMIIVNAHKINNGEPLYLNTKGKD
                     FFFIRKSTNEEILNEIIGLVNERLPKFYKVDKLKDIQVLSSMRKGELGVTNLNIELQK
                     YLNKKEKFKVEESFSKRLFRVGDKVMQVKNNYTKKWETEDQKESGEGIYNGDIGYVYH
                     IDKDKKTIYILFDQTKIVSYLYDELDEIDHSFCTTIHKSQGSEFPVVVLPIAWAPPML
                     LSRNLLYTAVTRAKKLVVLVGDVKYLEYMIKNNRVNQRYSNLGYKLNKFKQEGLLIE"
     gene            25999..26781
                     /locus_tag="KRO40_000761"
     CDS             25999..26781
                     /locus_tag="KRO40_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HBH2091594.1"
                     /translation="MKICNDNFIKNFKNMINKCLDFIYPENISCIICDKSIKKTNTYS
                     ICKSCFKEMNFIQDGCMKCGKPIICHSIEKEFIEECSYCFNKDFYFDKSISCIEYNDV
                     TKKMVLGLKYNQKTFMAKYIAQIMKEKLYLENIKFDYILFVPLHKKRLNKRGFNQAQK
                     IAFNLSKIVNIPLLDCISRKKYTRMLYKLNKKERKEELKNVFVVKENVKLINNKNILL
                     IDDIFTTGLTTNEISKLLKLSGANKVFVLTLLTKANDNYIME"
     gene            27113..29026
                     /locus_tag="KRO40_000762"
     CDS             27113..29026
                     /locus_tag="KRO40_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2091595.1"
                     /translation="MICLNKRQENLLTTLLLKEEFINVNKIANDFECSERTIRNDCKY
                     IDEWLSTFCNAYIKRKPNIGIKFSGDGTDKILVNQKLRGEVKRVNSELHKQVEILNLL
                     LCNNKKVTLNDLSNKLYINKNIVREEISKLSVALNNYNLNISTKKGSGIYIEGDEKDI
                     RIMLVSFLFKYIDKYRLNIDEIEYFHIVDIIIVKNIMLTIEEDMDIRLTDISFKQLML
                     FLLINIIRIRLGNSLKVSNTKKELKLKMLILDIEDELKSNLSIVLNYEEKLFIESLIL
                     GMNKQINSNNIKKSLYLNEELASYTKKIINLVSEESGINFNNDILLYEQLICHLNVTM
                     HQMKSNVYLENPLLDNIKTKFCFLFTVISSSIEIELKGKQITEDEIGYLTLHFQTSLE
                     RKYSKRESNKKASIVCPFSFGVSMLLKVKIEKRFDNIKIIETLREEDLKRDNFNKTID
                     FIIAFQEYENIQKPIFITTPLFTDEDENKLKEFTNKIKEKDTSYKLMNRLMMSDYLIR
                     ELEHDDIYEAITYLTNLLIEKHYAEKEYLQSIITREKSYPTNVGKGILFPHGDMKYIK
                     QSVLCFARLKTPIKIRNGKDIKIILLLAYKKDDDRKVFRELFKEISNLTEDENMLDIL
                     SKCDIEKVKDILI"
     gene            29167..29475
                     /locus_tag="KRO40_000763"
     CDS             29167..29475
                     /locus_tag="KRO40_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2091596.1"
                     /translation="MEEIVLKIIIHAGNAKSMLYEALDYAKENDFKKADELIENANEE
                     ILKAHKVQTELIQKEAGGDKSDISILLIHSQDHLMTCMSERNLIKEMIMLRKEIQKLK
                     "
     gene            29498..29824
                     /locus_tag="KRO40_000764"
     CDS             29498..29824
                     /locus_tag="KRO40_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091597.1"
                     /translation="MKRKVYLFCSFGMSTSLLADKMQKVADEHNLPIEVEAFPIAEID
                     KIVEEKNPDCILLGPQVKYMLKELKPKFEAQGKLIDIINEVDYGTMNGEKVLKLAIKL
                     IKSKQA"
     gene            29863..31197
                     /gene="celB"
                     /locus_tag="KRO40_000765"
     CDS             29863..31197
                     /gene="celB"
                     /locus_tag="KRO40_000765"
                     /EC_number="2.7.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HBH2091598.1"
                     /translation="MNRLERILMPLAEKIGKNKLLIAIRDGFLVSSPLLIIGSLFLLV
                     ANFPIKGWNEFVGQIFGPDWAVKLQQPTVATFEVMTLLAVLGIGYSYAKQIDVDPIAS
                     AAVAIVAFFIITPFVIPYTPEGTESVYMVTGIPLGWMGSKGMFVGMITAITSVKLFAA
                     VVKKGWTLKMPDGVPPTVSKSFAALIPSAIVMVVFFLVKIAFEATPYGSIHEFIFKFL
                     QMPLLKLGNSLGAMAIAYIFLHLFWFFGINGSSVVGAVYNPILKILSAENLAAFQAGS
                     KIPNIITGQFQDMFATFGGAGSTLSLVIAMLLICKSKRIKSMGKLSILPGIFGINEPL
                     IFGLPIMLNPILLIPFAIVPTINIIIAYFCMSAGLVPLTNGVQLPWTTPIIFSGFLTT
                     GWQGAVLQLVLLILGIFMYIPFIKMLDKQYLREENETVEEEDDDISFDDLVL"
     gene            31208..31729
                     /locus_tag="KRO40_000766"
     CDS             31208..31729
                     /locus_tag="KRO40_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/betaine/sarcosine/D-proline family
                     reductase selenoprotein B"
                     /protein_id="HBH2091599.1"
                     /translation="MKKIVMILDQIQAGAGGKEKSNIPPAGKSSPLGPGVMMEQFLNE
                     SKVIATLFCGDEFFVNNQEEVTSKMIAMVKKLNPDVVICGPSFNYENFSKMSAILSKN
                     INDKTDIPAFAAMSEENIDVINEYKNDICIVKTPKKGGIGLNDSLNNICKLAKAIANK
                     EDITLMKEEFCYQ"
     gene            31822..32781
                     /locus_tag="KRO40_000767"
     CDS             31822..32781
                     /locus_tag="KRO40_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase"
                     /protein_id="HBH2091600.1"
                     /translation="MWGMIATWRMALEGITEASEHLEKGMEAGDAVELAVRRVEDYPF
                     YKSVGYGGLPNENCEVELDAAFMDGNTLDIGAVAGIRDYSNPVSIARKLSYEKVNNFL
                     VGIGAEDYAHKNGFERKNMLTDRAKLHYKKRKKETLDKGLSPYAGHDTVGMISLDKTG
                     KMCAATSTSGLFMKKRGRIGDSALSGSGFYVDSSIGGATATGLGEDLMKGCISYEIVR
                     LMKEGKHPQEACDIAVNELDKQLIERRGKAGDLSLVAMNNKGEWGVATNIADFTFSVV
                     TKEESPTVYISNRVDGKTIHKVISNEWMEAYEARIKAPIEVSE"
     gene            32830..33882
                     /locus_tag="KRO40_000768"
     CDS             32830..33882
                     /locus_tag="KRO40_000768"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Sapep family Mn(2+)-dependent dipeptidase"
                     /protein_id="HBH2091601.1"
                     /translation="MNIISNKIDELKEDLLSDIIDIVKIPSVKGESENGFPFGEKVGE
                     ALNKALEISEKLGFKVRNLDNYIGYAEHGDSDDYVCVIGHVDVVHEGDGWKHQPYKGE
                     ETNGRIYGRGVLDNKGPIMSALYGLYAIKELNLKLDKRVRIIFGTNEESGFEDIPYYL
                     EKEKAPIMGFTPDCKYPVVYGEKGMAKIRIKSKINYEEDVYLGFIENMSENVLVTYKE
                     LNIENSDTILDIKVKYDFSYKLKDVLDEIKASFPNSIDIEVISNFNPVYFDKESNLVK
                     KLQLAYERVTSLDGTPVTTNGGTYAKVMPNIVPFGPSFPGQKGIAHNPDEYMDIEDII
                     LNAKIFANAIYELAKE"
     gene            33885..34559
                     /locus_tag="KRO40_000769"
     CDS             33885..34559
                     /locus_tag="KRO40_000769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HBH2091602.1"
                     /translation="MLEIIGMSVEDAKIIEDCGADRIELVSALTEGGLTPSFGLIESV
                     VNSVKIPVNVMIRHHAKSFVYSKEDISIMQKDIGVVKEIGANGVVFGVLDKNNNIDEK
                     NLNVLLKCCDNLDVTFHRAIDESNTIDSVKILKDYDKITNILTSGGKGSIVDNIQMIK
                     NMMLSSNHIKILLGGGLNFNNIEKIKELTKASNFHFGTAIRINNSPFEDIDRQKLKQL
                     VNIISR"
     gene            35112..35663
                     /gene="raiA"
                     /locus_tag="KRO40_000770"
     CDS             35112..35663
                     /gene="raiA"
                     /locus_tag="KRO40_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBH2091603.1"
                     /translation="MNIIISGKQIELTDAIKNKIETKLSKLDNYIHPDTDVKVTVSAR
                     KARQKIEVTIATVNGPIIRAEDMQENLYTAIDVVYDKLSKQLKKYKKRLQDKHKDNKS
                     IRFQDAEINLADEQEDYGDENQELVIQRRKKFSVKPMSEEEAVLQMELIGHDFYMFKN
                     IDSDEIAVVYKRNNGGYGIIEHE"
     gene            35795..38470
                     /gene="secA"
                     /locus_tag="KRO40_000771"
     CDS             35795..38470
                     /gene="secA"
                     /locus_tag="KRO40_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBH2091604.1"
                     /translation="MSFMDNLFNMADKKELKKFNKTVDIIDSLEPKFESMADSELKNM
                     TNIFKERLANGESIDDILPEAFAVVREVSKRVLGLRHYRVQMIGGIVLHQGRIAEMKT
                     GEGKTLVATAPVYLNALTGKGVHVVTVNDYLAKRDRDQMAKIYEFLGMSVGVIIHGQN
                     PKVRKEQYDCDITYGTNNEYGFDYLKDNMVIHKEQRVQRGLNYAIVDEVDSILIDEAR
                     TPLIISGPGDKSTHLYSDANTFVLTLKPDDYELEEKDKAVSLTASGIQKAEVYFNVDN
                     ITDISHTELYHHINQALRAHVIMKKDVDYVAKDGEIVIVDEFTGRLMFGRRYSEGLHQ
                     AIEAKEGLKIQRESKTLATVTFQNYFRMYKKLSGMTGTAKTEEEEFKAIYKMDVFQVP
                     TNKLMIREDLPDCVYKSEIGKFNAVAQEIIERHKVNQPILVGTVSIEKSELLSQILKK
                     KGIKHEVLNAKHHDKEAEIIAQAGRLGAVTIATNMAGRGTDIVLGGNPDFLTKREMRR
                     NGFKEEIVNRVDTPIEGIPVKGNEILFEAREEYEKLFEKFKQQTQEEQKQVVEAGGLA
                     IIGTERHESRRIDNQLRGRAGRQGDPGSSRFYIGLDDDLMRLFGSDRISGIVDKIGLE
                     EDMPIEHRILSKSIEGAQKKVEGKNFGIRKHVLQYDDVMNKQREIIYAERKRVLEGED
                     LQEQIQSMTHSIIEEAVTLYTQDKGFDEEGFKEHMYNLFLPKGSIEIPEIEKLNPVEI
                     TEKVYEIAMKIYTSKEEQVGYERMREVERVILLQAVDNHWIDHIDAMDQLRQGIGLRA
                     VGQQDPVIAYKMEGFDMFDEMNKHIKEDTVRYLFNITIETPVERKAVVDVENLSSPSD
                     GTLPTSKTVKKDEKVGRNDLCPCGSGKKYKNCCGR"
     gene            38485..39592
                     /gene="prfB"
                     /locus_tag="KRO40_000772"
     CDS             join(38485..38559,38561..39592)
                     /gene="prfB"
                     /locus_tag="KRO40_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_153309863.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HBH2091605.1"
                     /translation="MLKLQEYRHSMEQMASNLEELRVSLDIASLMKNIQINEEKMNQQ
                     DFWNDNEVAQRVLQENKSLKETLEEYESLKSLLEDIEVLIEIGLEEDNDSVERDIEKS
                     IESMEEKLSEMKIKTLLNGEYDKNNAILSINAGTGGLDAQDWAQMLLRMYIRWSESKG
                     YKVKLLDIISDPEAGIKTATILVEGTNAYGYLKSEKGVHRLVRISPFDPSGKRHTSFA
                     SIDVTPELDENIEVEINPSDLKIDTYRASGAGGQHVNTTDSAVRITHIPTGVVVQCQN
                     ERSQHLNKDRAMRLLMAKLIELKELEQKEKIEDIQGKYSQITWGSQIRSYVFQPYKLV
                     KDHRTNAEFGNVDSVMNGNIDLFINEYLKMNKIV"
     gene            39736..41877
                     /locus_tag="KRO40_000773"
     CDS             39736..41877
                     /locus_tag="KRO40_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HBH2091606.1"
                     /translation="MDINQILKKEFNLRDEQINNTLKLIDEGNTIPFIARYRKEMTGE
                     MSDVTLREFYEKLMYLRNLQSRKDDVVRLIDEQGKLTDEITQNIEKAKTLQEVEDIYA
                     PYKQKKRTRATIAKEKGLENLALSILENNLDNIEIEAKNYLDEEKEVLSIEDALKGAR
                     DIIAELVSDDAKIRKYIRELALREGMIVSKSATDEKSVYDMYYDYSEAVKSMAPHRVL
                     AINRGEKESFLKVKLEINNDKVLNYIINEYVNDKNFKNKEEIVSSIEDSYKRLIFPSI
                     EREIRNHLTEIAQERAISVFGKNVKSLLLQPPVKDKVVMGFDPAFRTGCKIAVVDKNG
                     KLLDYTTVYPTDPQNDVEGAKKVLKGLIEKYDIDIISIGNGTASRESETFVSEMIKEI
                     DSEVQYVIVSEAGASVYSASELANEEHPDINVSIRGAISIARRLQDPLAELVKIDPKS
                     IGVGQYQHDLNKKRLEEVLDGVVEDSVNSVGVDLNTASYSLLEHVAGISKAIAKNIIA
                     YREENGDFTSRAQLKKVKRLGPQAFTQCAGFMRILEGKNPLDNTGVHPESYDICKKMI
                     EIIGYSLDDVKNKNIGEIDEKIKEIGLRELSEKLEVGQVTLKDIIAEIKKPGRDPREE
                     GIKPILRTDVLKIEDIQEGMTLKGTIRNVVDFGAFVDIGIKNDGLVHKSEMSNSFVKD
                     PMSIVTVGDIVDVKVIGIDLNKKRVALSMKK"
     gene            42025..43191
                     /locus_tag="KRO40_000774"
     CDS             42025..43191
                     /locus_tag="KRO40_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2091607.1"
                     /translation="MIFIKNGKINTITNGIIHGDILIDEGKIIEIGEDLIAPLDVEVI
                     DASNKLVFPGFIDAHTHLGLWEDGIGFEGADGNEETDPITPQLNPIDGINPMDRTFKE
                     AFEGGITSVCTTPGSANVMGGQCIAIKTCGKRIDKMVIKNPVASKIAFGENPKSCYGQ
                     DDKSPQTRMAIAALLRENLKKAEEYLEDIDMYESHDDEDCEKPEYDIKMESLIPVLRR
                     EIPFKAHAHRADDMFTAIRIAKEFNLKLTLDHCTEGHLIVDELVEEGFPVIVGPSLSE
                     RSKFELRNLTFNTAGILSNAGLDVCIMTDHPVIPVQYLPICAGIAVKHGMKEEKAIES
                     ITINPAKALGIEDRVGSIEVGKDADLVIWDNSPLEIQSNVLYTIINGKVVYEKK"
     regulatory      43251..43368
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            43493..44098
                     /locus_tag="KRO40_000775"
     CDS             43493..44098
                     /locus_tag="KRO40_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH2091608.1"
                     /translation="MQNTAKRGNMISTRTLVVMSILSAISYLLMFIQAPIPGIFPDFL
                     KIDLSDIPAIFGGMSLGPLVGFGIVVVKNVLQAITATTTGGIGEFANILIGGSYVMIL
                     CYSYKRSGDLKGVLIGFVLGTISMTIIGSLVNYFVMLPLYGQLMGLDAIIGLGSAINP
                     QVHDLFTFVIWMIAPFNVLKAVIISLVTLPLYKKMGNIIKK"
     gene            44427..45467
                     /locus_tag="KRO40_000776"
     CDS             44427..45467
                     /locus_tag="KRO40_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH2091609.1"
                     /translation="MHLSKKIKKLFLDDKGYYFNSNWKDIHIGIYDTKLGDSLKYITN
                     EYIENMERVKYDYRELKNIENQTDGMCILAIRQNYKALEYVKNQTEELCLEAIKYNYK
                     ALEYVKEQTEYLCLEAIKKDCNALKYVRNKTEGLIIKAISHSSNIDVVSILKALETQT
                     RRICLEAIKKDGRCLAYVREQSEELCIEAIKQNYKALKYVKNQTEKMCIESVRQNGMA
                     LQYVNKQTDKICIEAVKQDGRSLQFVNNKTEEICINAIRYLNKKYNIKDVLSYIDKYT
                     EDICIEIVRQNGKMLMYIKNQTEKMCIEAVKENYKSLKYVKEQSERICKEALKQNHKA
                     KEYVKIAIDDCI"
     gene            45606..46058
                     /gene="tsaE"
                     /locus_tag="KRO40_000777"
     CDS             45606..46058
                     /gene="tsaE"
                     /locus_tag="KRO40_000777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HBH2091610.1"
                     /translation="MAKIYLENENKTREIGYKLGKLLKEGSVICLVGDLGAGKTTMTQ
                     SLADSLGIEDYITSPTFTIINEYEGKIPLYHFDVYRIGSSDEMYDIGYDEYVNSNGIC
                     IIEWANLIEDILPKEYLNIELRYKDEGREMILTPKGEFYKEIVEELIK"
     gene            46058..46774
                     /gene="tsaB"
                     /locus_tag="KRO40_000778"
     CDS             46058..46774
                     /gene="tsaB"
                     /locus_tag="KRO40_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HBH2091611.1"
                     /translation="MKILGMDTSSMAASVAVVEDDNLICEFTVNNKKTHSQKLMPMIE
                     NMLSMSDLSIKDMDLLAVCIGPGSFTGLRIGMATVKAMAHVNNIPIIAVNSLESLANN
                     INFCDRKICCILDAQKNQVYSAKYKFENGEMIELDGVDVVEFDALVDEIVSTNEEFII
                     VGEAVYKYKDKLENIKNIKIPSPANNVSNAGSLCSLALNKYNKNIDVHTCYTINPMYI
                     RKSQAEVQYDEKMKRLNNGR"
     gene            46764..47240
                     /gene="rimI"
                     /locus_tag="KRO40_000779"
     CDS             46764..47240
                     /gene="rimI"
                     /locus_tag="KRO40_000779"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HBH2091612.1"
                     /translation="MEDNTKLIVDDIKIEEMTTEDIDEVFEVEKNCFEDYWSKESFRK
                     ELSNEVARYIVAKLNGKIVGYVGIWLILDEGHINNVAVHSDYRGKKIGDKLIKGIVDL
                     CKDNNIASMTLEVRASNKIAQNLYRKYGFKMGGIRKEYYSDNKEDAIIMWNQLKEV"
     gene            47246..48262
                     /gene="tsaD"
                     /locus_tag="KRO40_000780"
     CDS             47246..48262
                     /gene="tsaD"
                     /locus_tag="KRO40_000780"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HBH2091613.1"
                     /translation="MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGG
                     VVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIAVTYGPGLVGALLVGLSYAKALA
                     YTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKT
                     RDDASGEAFDKISRAMNLGYPGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLK
                     SSVLNYLNGKRMKNEEIVVEDVAASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVAS
                     NSGLRAKITELAKDNGITVKYPPLILCTDNAAMIGCAGYYNFINGKTHDMSLNAVPNL
                     KINQ"
     gene            48559..51267
                     /gene="hpdB"
                     /locus_tag="KRO40_000781"
     CDS             48559..51267
                     /gene="hpdB"
                     /locus_tag="KRO40_000781"
                     /EC_number="4.1.1.83"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase large
                     subunit"
                     /protein_id="HBH2091614.1"
                     /translation="MSQSKEDKIRSILEAKNIKSNFQNKENLSEFNEKKASKRAEDLL
                     DVYYNTLSTADMEFPYWYNREYRKSDGDIPVVRRAKALKAAFSHMTPNIIPGEKIVMQ
                     KTRHYRGSFPMPWVSESFFVAQGEQMREEAKKLASNTADELTKFGSGGGNVTESFGNV
                     VSIAGKFGMRKEEVPVLVKMAKEWVGKSVEDLGFHYEKMMPDYDLKENLMSTLICMFD
                     SGYTLPQGREVINYFYPLNYGLDGIIEMAKECKKAVAGNASGDGLIGMDRLYFYEAVI
                     QVIEGLQTWILNYAKHAKYLESIETDLEAKKEYSDLVQILEHIAHKQPRTFREALQLT
                     YTIHIASVNEDAISGMSIGRFGQILYPWYEQDIEKGLITKEEVIELLELYRIKITCID
                     CFASAGVNGGVLSGNTFNTLSIGGLKEDGSTGANELEELLLEASMRCRTPQPSLTMLY
                     DEKLPEDFLMKAAECTKLGSGYPAWVNNSNGTTFMMKQFADEGMTVEEARAFALGGCL
                     ETSPGCWKQLTLNGKTYSIAGGAGQSAGSGVHFIANPKILELVLMNGKDYRMNIQVFE
                     PHNKPLDTYEEVIEVFKDYYKQAINVLERANNIELDIWRKFDTSIINSLLKPDCLDKG
                     QHIGNMGYRYNATLNVETCGTVTMVNSFAALKKLVYDDKAFTIEEMKDAILNNFGFKD
                     ALEVGNYSMADQVKVDKTGKYDAIYKACLDAPKYGNNDLYADNILKNYEVWLSKVCEE
                     AQSLYAKKMYPCQISVSTHGPQGAATLATPDGRLSGTTYSDGSVSAYAGTDKNGVYAL
                     FESATIWDQAVVQNSQMNLKLHPTTIKGQQGTKKLLDLTRSYLRKGGFHIQYNVVDSE
                     TLKDAQKNPDNYRQLMVRVAGFTQYWCELGKPIQDEVIARTEYEGV"
     gene            51271..51528
                     /gene="hpdC"
                     /locus_tag="KRO40_000782"
     CDS             51271..51528
                     /gene="hpdC"
                     /locus_tag="KRO40_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase small
                     subunit"
                     /protein_id="HBH2091615.1"
                     /translation="MRKHSDCMNFCAVDATKGICRLSKQMINLDDAACPEIKVMPKCK
                     NCKNFVEANDEGIGKCVGLEKEDWVYSTLNAITCEGHVFNE"
     gene            51521..52471
                     /gene="hpdA"
                     /locus_tag="KRO40_000783"
     CDS             51521..52471
                     /gene="hpdA"
                     /locus_tag="KRO40_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase activase"
                     /protein_id="HBH2091616.1"
                     /translation="MSSQKQLEGMIFDVQSFSVHDGPGCRTTVFLNGCPLSCKWCANP
                     ESWTVRPHMMFSELSCQYENGCTVCHGKCKNGALSFNLDNKPVIDWNICKDCESFECV
                     NSCYYNAFKLCAKPYTVDELVQVIKRDSNNWRSNGGVTFSGGEPLLQHEFLHEVLLKC
                     HEVNIHTAIETSACVSNEVFNKIFNDIDFAFIDIKHMDREKHKEQTGVYNDLILENIS
                     NLANSDWNGRLVLRVPVISGFNDSDENISDIISFMHKNNLVEINLLPFHRLGESKWIQ
                     LGKEYEYSDKGDVDEGHLEELQDIFLDNGIACYVGHETAF"
     gene            52786..53748
                     /locus_tag="KRO40_000784"
     CDS             52786..53748
                     /locus_tag="KRO40_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2091617.1"
                     /translation="MNKSWSNLIIKNKDRKVRSGWIIIAVMATFYILQYYLSMILVEI
                     IRKILVATGDINLKTNYFSEYANWLNDVGLQIVFQILTDSLMIIIPIIVWRFIMKNPI
                     SEMGLHSYRIKKKEGYVGMLLGIFNCTVIFIITITIGGGHVTSWVPKISPLTVSWILV
                     FILVAFAEEILNRGFFMAVLRRCKNIYFIMIVPSVIFGLIHIWNPDVTFLSVINIIII
                     GILFSYMFIKSSNIWMCIGYHFAWNVFQGIIYGMPVSGLQVPGIITTQITHGNLLNGG
                     MFGIEGGILTTFVNLLSFIFVWYYYRDSKYDFVSDKVNVTNIKN"
     gene            complement(53847..54650)
                     /locus_tag="KRO40_000785"
     CDS             complement(53847..54650)
                     /locus_tag="KRO40_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2091618.1"
                     /translation="MMILPLSSVAIAKFYTEGLNNDMYEFYSLIILFFLIYSLLIVLK
                     LLNLINNNEFIIINLILTFISSLSIIIYSSNKKNLYPVKNIKLGSLLIIYFMISVIVP
                     TSFILILQGAQPNYSGIIKFIFTPITSLTTIYIFFSEEYAWRGFLQNIFFDKFGKKLG
                     VIILGMCWSLWHLPLIFTLYTPEAPILGIILRSIHIVGISIFLGYLYIKTKNIWFCAI
                     IHVLNNSAFLITNSKESTITYHDILIVSMVVLIFYVPFLFTKEYKNNLE"
BASE COUNT        22105 a         5812 c        10354 g        16554 t
ORIGIN      
        1 tatacataat aagttttaat gatagtttat agtaagatat taaaataaat ttatctaatc
       61 tagatatgaa ataagttatt actttaatat aaaaatgaat ctaatggaat aatattgatg
      121 ataagtaata tttagatttt gtatttgttt atagttaata agtggattat agaatttata
      181 ataattaata tatattaaac aaagatatat taagatattt tagaacataa aactgaatta
      241 aggcgcgagt actattttgt attcgcgcct tgatggtttg agttatttga gtaaaaacta
      301 actttaataa gaaatatgta tttattaagt tgatattttt aatgtgttta gagattattt
      361 aacaatctcc aaatataaaa ctagaattat ttacataaaa gttaaatagt ttgtatagag
      421 ttagatttat atagtataat acttagtgta aataattaag aagttatcaa acaggaggat
      481 aaaactgtgt tagatataaa ttctttttta aatggatttt ttaatataat attaagaatg
      541 agtatatatg atttaattga catatctata gtagcgtata ttttttacaa aatatttatg
      601 tttataaaag atacaagagc agaacaagtg tttaaaggta taatatttct tttattagca
      661 actcaactta gtaacacctt taaattgcat accgtttatt ggatatctct taaagcttta
      721 gattatggag ttatagctgc tcttataatt tttcaaccag aatttagagc aggacttgaa
      781 catataggaa gagcaaagtt taatttattt ggaaagaatg taaatacttc tgaagaaact
      841 ctcaatagaa atatagaaga aattgtagaa gctttatatt cactttctag acaaaaaata
      901 ggagctctta tcataatgga gagagaaact agaataagtg atataataaa tacaggaact
      961 attattgatg ctgaaatttc taggcaacta ttaataaata tatttatacc aaatacacca
     1021 ttacacgatg gagctgttgt aattagagat tctaaggtaa aagcagctgc atgttttttg
     1081 ccattgacag aaagtaagga tttaagtaaa gatttgggca ctagacatag agcaggaata
     1141 ggggtaagtg aggtgtctga ctgtataact ctgattgtat cagaggaaac aggtggcgta
     1201 tcaattgcta aagcaggtaa gttatataga gatatttcta gagaaagaat gatgaatata
     1261 ttacgtagta atttaaaaac aaatacagaa acaagaagtt ttttcaaagg tggtatattt
     1321 aaatgataaa tagactaaaa aataatacca aaataaaaat aatatcattt ttaagtgcaa
     1381 ttgcattatg gatgtatgtt atggctgtag ttgaccctga agaaactaaa gggtttgaag
     1441 atatacctgt atctataagt aatatgagtg atttaaagga taaaaatctt gttatatatc
     1501 cagacgaaaa attaacagca gatgtatata taaaaggtag tttatcaaag gtacaaagtg
     1561 ttaaaaaaga agatatacat gtatatggaa ccattgaaga cccaatacaa ggacagaagg
     1621 aagtatattt aaaagcaaat attcctcaag gtgttactct agaatttaag catgatgttt
     1681 tagtagtaaa tcttgaaaaa aacataaaag aaaaaagaga tataaaggta gaagtaagtg
     1741 gaaattcaaa aagaaatata aataaaattg aacttagtaa ggaatttgtc gatgtatcag
     1801 gtccaagaac tctagttaaa gaagtcaaaa gtgtaagagc taatctagat gttggtaatg
     1861 agacagatga tttttctaaa aaattgcaat taataccatt aaatagtgat ggaactaagg
     1921 ttgaaggagt aacattaagt tcatcctttg tgactgcaaa gatagagcta ttgaaggaaa
     1981 aaattgtccc aataagagta agtctaaatg ataataaaga taatgatgta ctgaaaaact
     2041 ataaattaag taaggaacaa gttacaataa aaggaaagaa agatgatata gacaaaataa
     2101 gttatattaa gacaaaacct attgacttag ctgatttggc taatggtgaa gaaaaagaag
     2161 ttagcttaga aattccagag ggtataactc ttgaggatag ctctataaca attaaattaa
     2221 atgatacaaa acaattgagt gcagaatttt tatataatgc gggagatatt gaattaagaa
     2281 atatcccaac aaatatggat aatccaaatg taatttctga tgtagatata aaagttgttg
     2341 tagagtcaac ggaggatttg agtaagttaa ataaaaaaga tatttcatta tatattgatt
     2401 tatcacaagg tcctgaggaa gatagtaaat ataaaataaa atatgaaaca acatatcaat
     2461 ttaaaaaaat aaatatagaa cctaatattg ttgaagtgga atgaacaaat atttcgaata
     2521 tttagttgtt acaagatgcg acaaaaaaac ctataaaatt aagtttgtta attttatgtt
     2581 tttgttgcat cttgtttatt ttagttatat tataaaataa ggacaatgag atatttgtta
     2641 aatctaaaaa gcgctagata tatgaaaaaa gactgataaa tagatttaaa taaatatttt
     2701 gaattaaata tttcaattat ctctaggaaa acgttgctga acgagttata atttaattga
     2761 gatataaaaa gttctatttc aaaaaattca agatgaggtg gaaatgcatg agaagttttg
     2821 aagaagtaat taagtttgca aaagaaagag gacctaaaac tatatcagta gcatgttgcc
     2881 aagataaaga agttttaatg gcagttgaaa tggctagaaa agaaaaaata gcaaatgcca
     2941 ttttagtagg agatatagaa aagactaaag aaattgcaaa aagcatagac atggatatcg
     3001 aaaattatga actgatagat ataaaagatt tagcagaagc atctctaaaa tctgttgaat
     3061 tagtttcaca aggaaaagcc gacatggtaa tgaaaggctt agtagacaca tcaataatac
     3121 taaaagcagt tttaaataaa gaagtaggtc ttagaactgg aaatgtatta agtcacgtag
     3181 cagtatttga tgtagaggga tatgatagat tatttttcgt aactgacgca gctatgaact
     3241 tagctcctga tacaaatact aaaaagcaaa tcatagaaaa tgcttgcaca gtagcacatt
     3301 cattagatat aagtgaacca aaagttgctg caatatgcgc aaaagaaaaa gtaaatccaa
     3361 aaatgaaaga tacagttgaa gctaaagaac tagaagaaat gtatgaaaga ggagaaatca
     3421 aaggttgtat ggttggtgga ccttttgcaa ttgataatgc agtatcttta gaagcagcta
     3481 aacataaagg tataaatcat cctgtagcag gaagagctga tatattatta gccccagata
     3541 ttgaaggtgg taacatatta tataaagctt tggtattctt ctcaaaatca aaaaatgcag
     3601 gagttatagt tggggctaaa gcaccaataa tattaacttc tagagcagac agtgaagaaa
     3661 ctaaactaaa ctcaatagct ttaggtgttt taatggcagc aaaggcataa ttttaagggg
     3721 gaaataggca aatgagcaaa atatttaaaa tcttaacaat aaatcctggt tcgacatcaa
     3781 ctaaaatagc tgtatttgat aatgaggatt tagtatttga aaaaacttta agacattctt
     3841 cagaagaaat aggaaaatat gagaaggtgt ctgaccaatt tgaatttcgt aaacaagtaa
     3901 tagaagaagc tctaaaagaa ggtggagtaa aaacatctga attagatgct gtagtaggta
     3961 gaggaggact tcttaaacct ataaaaggtg gtacttattc agtaagtgct gctatgattg
     4021 aagatttaaa agtgggagtt ttaggagaac acgcttcaaa cctaggtgga ataatagcaa
     4081 aacaaatagg tgaagaagta aatgttcctt catacatagt agaccctgtt gttgtagatg
     4141 aattagaaga tgttgctaga atttctggta tgcctgaaat aagtagagca agtgtagtac
     4201 atgctttaaa tcaaaaggca atagcaagaa gatatgctag agaaataaac aagaaatatg
     4261 aagatataaa tcttatagtt gcacacatgg gtggaggagt ttctgttgga gctcataaaa
     4321 atggtaaaat agtagatgtt gcaaacgcat tagatggaga aggacctttc tctccagaaa
     4381 gaagtggtgg attaccagta ggtgcattag taaaaatgtg ctttagtgga aaatatactc
     4441 aagatgaaat taaaaagaaa ataaaaggta atggcggatt agttgcatac ttaaacacta
     4501 atgatgctag agaagttgaa gaaagaattg aagctggtga tgaaaaagct aaattagtat
     4561 atgaagctat ggcatatcaa atctctaaag aaataggagc tagtgctgca gttcttaagg
     4621 gagatgtaaa agcaatatta ttaactggtg gaatcgcata ttcaaaaatg tttacagaaa
     4681 tgattgcaga tagagttaaa tttatagcag atgtaaaagt ttatccaggt gaagatgaaa
     4741 tgattgcatt agctcaaggt ggacttagag ttttaactgg tgaagaagag gctcaagttt
     4801 atgataacta atgataaaag aataagaatc ataactggtc actatggaag tggtaaaagt
     4861 gaatttgcga tgaactatgt tgttaagtta agagatatgg tttctggcaa agttgctata
     4921 gccgatttag atgtggtaaa tgtatacttt agaactagag aaaagaaaga gttaatgaaa
     4981 tccttaggta tacaaccaat agatagctca attaatgctc caacattaga tttaccagca
     5041 gtatcagcag aggtaatgtc tcctatggta gaccattcat acaattctgt tatagattta
     5101 ggtggagata atgtaggtgc tagggttata ggaagattta gtcatttgtt aaaagaaggc
     5161 gattatgata tgctttttgt aataaatgca aatagggaga aaactcaaac ttctgaagaa
     5221 gttatccaat atataaaaga aatagaaaaa tcttctaaat taaaggtaac aggtctaatt
     5281 aataatactc atcttattag gtttactact attgatgatg ttttaagagg tcagaaagtt
     5341 gcaaaagaag tttctgaaaa atgtaatata ccgataagat atgttgcatg tttagaaaat
     5401 cttgttgaac agttaccaaa agatttagaa ggagaaattt ttcctataaa attatatatg
     5461 agagaagact ggatgtagtt tgagctcaaa tatatagaaa gtttaaggag gcttaggtaa
     5521 atggctaaag gaaaagtatc ttttaatcaa gaacgttgta aaggttgtgg attgtgtgtt
     5581 gaagcatgtc cagtaaaaat catacaatta gactcaaatg taataaacaa aaaagggtat
     5641 aacccagcaa ctgtttttga aatggaaaaa tgcataggat gtgcaagttg tgcaactatg
     5701 tgtccagatg tagttataac agtagaaaga gattaattta attaatattt aagggggaat
     5761 tttaatggct aagatactta tgaaaggtaa cgaagcattt ggaaaagcag ctatagaagc
     5821 tggttgcaaa tatttcttcg gttacccaat aactccacaa agtgaattac cagaatattt
     5881 atcaagagag ttacctaaaa taggtggagc gttcgttcaa gctgaatcag aagtttctgc
     5941 gataaacatg gtttatggtg gagcaggtgc aggagcaaga gttatgactt cttcatcttc
     6001 accaggagtt gctttaaagc aagaaggtat aacatatgca gtaggagcag aagttccttg
     6061 tgttgtactt aatgtaatga gaggtggtcc aggacttgga agtatacaac cttcacaagc
     6121 tgactacttt atgtctacaa gaggtggagg aaatggagac tacagaactc cagtattcgc
     6181 accagctaca gttcaagaag ctgttgatat gataatggaa gcttttgacg ttgcagatta
     6241 ttacagatca ccagttatgg tagttgcaga tggtatgata ggtcaaatga tggagccagt
     6301 tgaatttaga gctcctgaga agaaaagaga attgcctcct aaagattggg caactgttgg
     6361 aactaaagga aaaagaaaac ctaatgtaat aaactctcta tacttagagc cagaagtact
     6421 agaagaccat tgttggcatt tacaagaaaa atttgatgca atggaaaaga atgaagtaca
     6481 atacgaaatg tacaaaacag aagatgctga atttgtattt gcagcttatg gaactacttc
     6541 aagagtagta aaaagcgcaa ttgatatatt aagagaagaa ggaataaaag caggtcttat
     6601 aagacctaaa gtattatggc cattcccatt cgaagcattc aaccaaattc ctaatgctag
     6661 aaacatattg actgttgaaa tgagtatggg acaaatggtg gaagatgtta aaatggcagt
     6721 agaaggtaaa ttaccagttt acttccatgg aagaccagga ggaatgactc caacaccagc
     6781 agaaatagtt gaaaaagcta aaaaaattat tgccggagaa ttggttgcag gaggtgctag
     6841 ataatggctg ttgtatttaa gaaaactgaa ggattacaag atactcaaac tcactactgt
     6901 ccaggatgta cacatggtat aatccataga ttagttggtg aagtattaga agaactagga
     6961 gtattaggtg atgctgtagg tgttgttcca gttggatgtt cagttttagg atataaatat
     7021 tttaactgtg acactcaaga agctgctcat ggtagagcgc cagctgctgc tacaggaata
     7081 aaaagagttc atcctgaaaa tacagtattc acttatcaag gtgatggaga cttagcttca
     7141 attggtactg ctgaaatagt tcatgcagct gctagaggag aaaaaataac tactatattt
     7201 gtaaacaata caacttatgg tatgactggt ggacaaatgg ctccaactac attagttgga
     7261 caaagagcta ctactgctca atcaggaaga aatgctgaaa ctcaaggtta tccaataaga
     7321 gtaagtgaaa tgttagctac attaacagga gctgtatttg tagaaagagt agcagttgat
     7381 actccagctc atgttagaca agctaaaaaa gctataaaga aagcattcca agttcaacaa
     7441 gcaggattag gatttggaat agtagaagta ttatctactt gtcctacaaa ctggggacta
     7501 gctccaaatg atgctttaca atggttaaga gacaacatga taccatacta tccattagga
     7561 aatttcaaaa atgttgaagt tgaggaggtg aagtaaatgt ctacagctag agtaatatgt
     7621 gcaggcttcg gaggccaagg tgttatgtct atgggacaat tacttactta tgcaggaatg
     7681 ctagaaggaa aagaagtttc ttggttacca tcttatggac cagaaatgcg tggaggtaca
     7741 gcaaactgtg cagtaactgt atctaatgag ccagttggtt ctccacttat aacagatgat
     7801 gcaactgcag ctatattatt aaatatacca gcatttgaaa aattcaaaga tgatgttatt
     7861 cctggtggaa aaataatagt aaatagttct ttaataaaag aaaaagttga tagaacagat
     7921 gtagatgttt attatatacc agcaaatgaa ttagcagctg aattaggaaa tgataaagtt
     7981 gctaacatga taatgttagg cgcttactta aaagtatctg atactgtaga tatagaatct
     8041 gtactagaag cattcaaaaa agttttcgga cctagaaaag aaaaattcgt tccattaaac
     8101 agagaagctt tacaaaaagg tatggatgct acatgttcta aagcaactaa ctaataaaga
     8161 aaaagatgtc aaaaaaaaga caatagaatt atttctattg tcttttttgc tgataagtat
     8221 taaaatattt ttatgactga aattaagcct ataatgatat tttatgaact ataaaaatat
     8281 aatacaaatt acaagctttt caattatgaa aggagaatct ttagtgagaa agtattttgg
     8341 aacagatgga gttagaggag tagcaaatac agaactaaca tgtgatttag catataaact
     8401 tggtagagct ggtggatttg tcttagctca aggagaccac agagtaaaag tagtagtagg
     8461 taaggatact agaatatcag gtgatatgtt ggaagcatct ttaatagcag gacttatgtc
     8521 tgttggatgt gatgttatta ctgttggaat aataccaaca cctgcagtgg catatttaac
     8581 tagaaaatat ggtgctgatt gtggtgtggt tatatctgca tctcacaatc ctgttgaata
     8641 taatggaatc aaattcttta ataagaatgg atataaatta gatgatgaaa ttgaattgaa
     8701 aatagaagaa tatatagacg atatagacaa aattgattgt cttccaattg gtgaaaatgt
     8761 aggaagaaaa ttacatgaac attgtgcaca aagagactat gtagactacc taaaatcaat
     8821 aataagcact gactttaagg gattaaaagt agttttggac tgtgctaatg gtgcgtcata
     8881 taaagtggca ccaatagtgt ttgatgaact aggagcaagt gtaatttcaa taaatagttc
     8941 accagatgga aataatataa actataaatg tggctctaca catccagaac aacttcaaag
     9001 ggctgttttg gaacataatg ctgacttagg tcttgcatat gatggagatg ctgatagatt
     9061 aattgcagta aatgaaaagg gtcaaattgt tgatggagac catataatga tattgagtgc
     9121 cttaaattta aagaaaaata ataaattggc acaagatact ttggtagtta cagttatgag
     9181 taatataggg ttgacaatag ctgctaagga aaatggaata aatttatcta ctacagcagt
     9241 tggagacaga tatgttttag aagatatggt taaaaatgga tataatcttg gtggagagca
     9301 atctggacat atgatatttt tagattacaa cactactgga gatggagtgc ttagttctct
     9361 aatacttgca aatataatct tgcaagaaaa gaaaccttta tcagaaattg catcaataat
     9421 gagccaatac ccacaagtat tagtaaatgc aacaataaaa aatgaaaata agaacaaata
     9481 tatggaatat ccagaaataa aaactgagat agaaagaata gaatctattt tagacggaaa
     9541 tggtagagtt ttgataagac catcaggaac tgagccatta gttagagtta tgttagaggg
     9601 taaagaggaa ggtcaaataa aagaattagc aacaaactta gctaatctta tacaagaaaa
     9661 attatcgtaa tttaaagggt attctcagat ataaatactg aggacacctt tctaagcgcc
     9721 agaacttagt tatagacata attattgagt aatataggaa ctaagttgac gaggtcagag
     9781 ttaatcgaat tgtcggcgga tgctctgcgg tgtgtttacc atcgaaagac ttctttaaat
     9841 aataggagca atcctatgga caaagggaag ccaaagtaaa cttatatgac ctaactctta
     9901 aaatatataa ataatatttt taggaggaca caaataatgt gtggaatagt tggatattta
     9961 ggaagtagaa aggcagcaga agttatagta gaagggcttt ctaagctaga gtacagaggt
    10021 tatgactcag caggagtagc agttaatagt tctaatgaaa aagaacttaa tattagaaag
    10081 tttaaaggta gactttctgt acttgcagaa gacttagaaa agaatcctat tgatggaaat
    10141 ttaggtatag ggcatacgag atgggcaact catggagaac catctgatgt aaactcacat
    10201 cctcatttta atcaagccaa aacaatagca gttgttcata atgggataat agaaaactat
    10261 atggaaataa aagaagaatt aatttctgaa ggtgttaagt ttgaatctca aacagataca
    10321 gaggtaatag cacatttagt agataaatac tatgagggta atttattaga tgctgtatac
    10381 aaaactatat caaaattaag aggagcttat gcattaggtg ttatatgtaa agaacatgga
    10441 aatgaattag ttgcagtaag aaaagatagt cctcttgtag ttggtgttgg tgaaggtgaa
    10501 aactttatag catcagatat acctgcatta ttaaaatata ctagagatgt ttatttctta
    10561 gaaaatggag aagtagttca tctaaaagac gaaaatgtaa cagtttatga ctctaataga
    10621 aatcttgttg aaaaagaagt atttcatgta acttgggatg tagaagctgc gtctaaaggt
    10681 ggatatgact actttatgtc aaaagaaatt catgagcaac caacaggagt aagagaaact
    10741 ttagaaagaa gacttgatga taatggaaat ataattctag acagtataaa tatttctaaa
    10801 gaagacttag aaaaaataaa taaagtttat atagtggctt gtggaacagc atataatgct
    10861 ggattacttg gtaagtatgc catagaaaaa tttgtaaata taccagtaat aactgatata
    10921 gcatcagaat ttagatatag cgacccattt gtagatgaaa attcattagt aatattagtt
    10981 agtcaatctg gtgagacagc agatactcta gcagtattaa gagattcaaa ggctaaagga
    11041 gcaagaatac tttcaataac taacgttgta ggttcatcta tagcaagaga atcagatgat
    11101 gtattctata cttgggcagg acctgaagta gcagttgcat caactaaggc atatactact
    11161 caaataactt ctttatacat gatagcttta gactttgcta tcaaaaaagg aacaataact
    11221 agagaatttt atgatagtat gatttctaag atgaaagaaa taccatcaaa aatacaagaa
    11281 atactagaca atgaagaata tataaaagaa gttgctaaaa cagttgttag ttctgaacat
    11341 gcattctatt taggaagagg tatagactat agcttagcaa tggaaggttc attgaaatta
    11401 aaagagattt catatataca tgcagaagct tttgcagcag gagagctaaa gcatggaaca
    11461 atagctttaa tagaaaaagg aactcctgta attgccatag ctactcaaga aaagttattt
    11521 gaaaaaatgg tttctaatat ggaagaagta agagcaagag gagcttatgt agtagcaata
    11581 gctcaaagcc ataataagga tgttgagaaa gctgctgata aaataatcta tataccaaat
    11641 tcagatgata ttttatcacc aatattagca gttgtaccaa tgcaattact tgcttatcat
    11701 gtctctgtac taagaggatg cgatgtagat aagccaagaa atctagctaa atcagtaaca
    11761 gttgaataaa aacagattaa aaattaaata gataatattt attgaaaaga actcatcctg
    11821 ttatttgtat tttataggat gagtttttta gataaatatt aaatttgttt tgtttttgct
    11881 ataataaatt ttataaaaag attgatatta aatcatctgt aaaatgataa atatatagac
    11941 cataccaggt atagggaacg ataaatatag ttcatataaa atatagtgag tacttaataa
    12001 acatatagtc aatatcagat aaaaaaaata atagcttatg agaaaaatta aaatacaagg
    12061 tattagtaac cttgtgataa gataaagtga gtagtttaaa ataagaatat aaggaactat
    12121 ttataaaaga atataatgaa gctaatagag tataagaaaa ttactttatt ttagtaaaat
    12181 aatttcaaat aaaaattttt ttaaattggg agtataaatt atgacaaatg attttaaaaa
    12241 agaaaagaaa gaagattatt ttgttaatct taaggcaata tctactgaag ttttacaaga
    12301 aaaagtgcaa gataacgctt gggttatagt tgatactcgc ttaaatgatg cttataatgg
    12361 ctggaagtta gatggagtaa aaagaggtgg acatataaaa ggagcagtag atttttctgc
    12421 taattggtta agtgtatact cagatagaaa agatgaagtg ttagaacaag cattgaaaac
    12481 taaaagaatt gatttagata aaaatatagt attgtatgat gcaaatggaa aagatgcttt
    12541 ggttgtagca aattatttat ctaaaaaagg atataaatat ctatataaat atgatattaa
    12601 acaatgggca gacgacgaaa atcttccaat ggaaagatat aaaaattatc aaatgatagt
    12661 tcctgctttt ataataaaag atatattaga tggaaaaatt cctgagacat ttgaagattc
    12721 aaagaatata aaaatgattg aagcgagttg gggaaaagaa tcgtatacaa aagggcatat
    12781 acctacaagt gttcatgtaa atactgatat tatagaacct cctccaacat ggatgcttga
    12841 taatgatgat aacttaacta agtttgcttt agactatgga ttaacaaagg atgatactgt
    12901 aatagtttca agtagtacac ctatggcatc ttatagacta gctgttatat tgagatatat
    12961 aggagtaaaa gatgtaagag ttttgaatgg tggaacaaac tcatggttat cagcaggata
    13021 tgaattagaa tttattagta atccaaaaca ttcatgtact aattttggag cagatatacc
    13081 agttaactca caattaattg ttactacatc tgaattaaga caaaaactaa aagaaaaaaa
    13141 taagtttata ctagtagata accgtacttg ggatgaacat ataggaaaag tatctggata
    13201 tacatattat gataaaaaag ggcgtatacc aggagcttta tatggacatt caggtagtga
    13261 tagtgtttca ctagaagaat atcgtaatat tgataataca atgagaaata aatatgagat
    13321 tttagaaatg tgggacaagg aaaatataga tgtgaataaa cagcttatat ttatgtgtgg
    13381 aagtggatgg cgtgctgctg aagtattaac atatgcaaat gtcataggag tggaaaatac
    13441 ctccctttat agtgatggat ggatgggctg gagtcttgat aattcaaatt taattgaagt
    13501 gggagaacac aaataaagtt tttgaaagtg caatagagtt gtttaaaaca aaggtgtttt
    13561 tgatttatta ggaagagtgt gtaaattgtg tattgggaag tgtacttagg tatgttcatt
    13621 tggagctatg gaaattgaca aaaaagtatt atctgtttat tttgttggta aaatatgaat
    13681 agattataga tttaagtata gactaagtaa tttatattac agaagagaat atataagaat
    13741 taatgcaaga tgtatttgat acatataaga aattggcaag tccaggagaa ggatagagaa
    13801 aattgagatt gaagagtttg aaagagatta ttagatgaaa aatacaaaaa tgtataaaaa
    13861 tacatattga gaaagtatat ctctcttaaa tttgttaata attctattat acagaaaaac
    13921 atatttaagg gggatttttt actatgaaaa aagtaaaatt agctataagc ttttttatat
    13981 taatgattat aggaatgaca atatcttatg cagatacaag tataaatact agatacaata
    14041 gattaagtaa agctcttgaa atatcagaag caaattttaa attttataat gttaaaatta
    14101 attctgttat aaatcataat ttatcaaata aagaatttca taatattttt atagaaataa
    14161 ttaacaatct aaagttggat aaaaaaggaa taaattggaa tcaaaaaggg tctggcgata
    14221 aaatacaatt atgtgctact ataaaaggta gcgataaaga aatttctata aaaggaataa
    14281 ataaaaataa caaagaaagt tacatagtag ttgacatatt ggataacaaa gtatataaac
    14341 ataaagaggt tatttatagt aacgtagaaa atgtgttaaa taaatattca tctcaagtag
    14401 atgtgtctgc ttgtattgtt ggagaataca caaaaaggtt acaaaacaac aaatatgatg
    14461 atattttaca aaaaatatta tataatatga gtgctaagca aatagatgaa gttaaagacg
    14521 taaacttttt atctataaca gcatatagta aagtattaaa tgattatgaa ttagaatatt
    14581 taggggaaaa aattaattta aatataggaa ttaaatataa tgaggatgac ggaaaaacac
    14641 tcatatatat tgccacacca attataaaat tagattatta attatgagga gatcaaaaaa
    14701 tatggctaag ataatagtaa aaaagagtaa tccacttaaa ggtagtgtta aaatagatgg
    14761 tgcaaaaaat gcagttttac caataatagc agcgacttta ttagcaaacg gaaaatcaac
    14821 attaaatgga gtaccaaatt taagagatgt tcatgttata tcagatttat taagacatgt
    14881 aggagcagaa gttgaatata aagaaaatac acttactgtt gatgcaagca atataaaaac
    14941 ttgtgaagct ccatatgagc ttgtaagaaa gatgagagct tcttttttgg ttatgggacc
    15001 attgcttgct agatttaata gtacgaaaat ttctatgcca ggaggatgtg ctataggaac
    15061 aagacctata gatttacatt taaaaggatt taaagcctta ggtgcaaaga tagaaatgga
    15121 ccatggtttt gttgaagcag caacagaaaa gttagtagga aataaattat atttagattt
    15181 cccatctgtt ggagcaactg aaaacataat gatggcagct tctttagcag aagggactac
    15241 aataatagag aatgcagcag aagagccaga aatagtagat ttagcaaact tcttgaacga
    15301 aatgggagca gatgttaaag gtgcaggtac taatactata aaaataaaag gtgttaaaga
    15361 gttaaaagga gcagaacata atgtaattcc agacagaata gaagcagcaa cttatatggt
    15421 tgcagcagct atgacaaaag gtgatataac tgttgaaaat gttttaatgg agcatttaaa
    15481 accagttgta gctaaattaa gagaagctgg ttgtgaaata acagaaatgg acaattctgt
    15541 aagagttgta ggtccaaaag tattaaaacc aatagatata aaaactttac cacatccagg
    15601 atttcctaca gatgttcaag cacaatttat ggctatgctt actgtagcca atggaactgg
    15661 tgtagttata gaaactgttt ttgaaaatag atttatgcat gttgctgaat ttaatagaat
    15721 gggtgctaat ataaaaatag atggaagaag tgcggttgtt aatggtgtag atgagctaca
    15781 cggtgcagca gtaaacgcta ctgatttaag agcaggggca gcccttattt tatgcggtct
    15841 tatagcagaa ggagaaactc aaataggaga aatataccat atccaaagag gttatgttga
    15901 tatagataag aagataacag cactaggtgg tcaaatcgaa atagtagaag attaataatt
    15961 ggtttataga agaaagttat aaattaatag ggttgttcat atacttaaat acaaggtttt
    16021 aaaagctaag gaggagagta tatgaagaac ccattggttg ttttgttagg atttgtgact
    16081 tgctctgtgt tagttccatc acttataact ttagtttctt ataaaaatgt agaattaact
    16141 gaaaaaccag agagcccagt atctataaac aaaactatta aaaaaagtga tattgaagac
    16201 aaaggtaata aagaagaaaa aaatacagtg aactatgaaa ctgtaaataa aaaagcacca
    16261 attatcaatg tatataatca tataacaggg aaaaccgaaa agatggacat ggagaactat
    16321 ttatgtggag tactagctgg tgagatgtct tcagagtttg atatagaagc tttaaaagct
    16381 caatctgtag cagctagaac atatgtagta tataaacagg aacatggtaa atctagtaaa
    16441 cataaaaatg cagtagtatg tactgattat aaacattgtc aagaatataa gagttatgat
    16501 actcttaaaa aattaaatgg tgaagaatgg attaagaata aatattccaa aatccaagaa
    16561 gcagttagag gaactaaagg tcaaataata acttataatg ataaggcgat acttcctctt
    16621 tatttttcta catcttcagg aaaaacagaa aatagtgaag aagtattttc tgcaaaatat
    16681 ccttatttaa agtctgtgga aagtccttat gataagtatt cccctaaatt tgcgtcaaca
    16741 cttaaaataa gtaacacaga ttttgttaaa agtcttagaa gggcatatag cactattgtg
    16801 atagatgtga ataatttaag taaacaagtt tcaataacta aaagaagtga tgccggaact
    16861 gtagaaaaaa taaaattagg aaataaagaa ttgactggaa aagacattag aactgttttt
    16921 aaattgaact ctgcaaactt tgacataaaa tttggagaag gatacataga tttcgtggta
    16981 aaaggatatg gtcatggtgt tggtatgagc cagtggggag cagaaggaat ggcagaagag
    17041 ggctataaat attatgatat attatcacat tactacacag atacaaaaat aaaagatata
    17101 tactaataat tgtataaaat gccaaaaaca cgtcaataat ccaaatgtag aaatatattt
    17161 ggaggtgcaa aatgaagaaa aagctgttag aaaaagatgg tttttattta tctttgtttg
    17221 tatgtgtttg tttattagca gtaggtggag tttggtttac aaataataat gtagataaat
    17281 tggcttctaa taaaggaatt atggaaaatg ctaataaaga tagtgaagag gaaatacatt
    17341 taattgaaaa agacaagaaa gatgctatcc ctactgcaac ggattcaaaa caaaacttag
    17401 aaaaagctaa gtcaaaagag gaaaataaat cgagtacaac aaaattaaat tacattggag
    17461 ataaagtaat aagaggatat tcagaaaaag agcctagtta ttctaaaaca cttgatgttt
    17521 gggaaactca taaaggtgta gatattagtt gtactaaagg caaagaagta aaatctctat
    17581 taaacggaat agtagtagat gtatttgatg atgaagaata tggacaatca gtcaaaataa
    17641 aaagtgacaa taacattgta gtagtatatt caaatctaga taaaaatgtt agtgttaaga
    17701 aagaacagaa ggtaacagaa ggacaatctc taggtactgt aggtagtact tctcaaatag
    17761 aaagtgaaga aggtatacat gtgcatttag aggcgtatag tggagaaaaa tctatagacc
    17821 caatgagtct aattaagtaa tagtataaca agtttaatca tatttggtta agcttgttat
    17881 attttttggt gtttttacat atatatcatt aaagctatta tgtgaggggg gtaatctttg
    17941 agatctcata tagaggaaag ggccatagtg gtagcaaaat atatacttga aaaaaacact
    18001 acagtaagac aaaccgccaa gacatttgga gtaagtaaaa gtacaattca taaggatgtt
    18061 acagaaagat tgaaggaaat aaatccatcc cttgccaaag aagttaaaaa tgtgctggac
    18121 aaaaataaat cagagagaca tattagaggg ggattagcaa cgaaattaaa atatgagaag
    18181 gaacataaaa aaatgtaggt taaaaaccta ctttttttat tgaattaaat tataaaaaga
    18241 aatatattaa gtaattataa atagcaaaat aataatactc tcaaaagatt tattttctct
    18301 tgattaaagc gagatttttg tatatgcttt attataggag tattaaaata ggcttataat
    18361 ataatctaat attataaata aaggagttga aaaaatggct ggagctgata taggcataga
    18421 tttaggtact gcaaatgtgc ttgtttatgt tagtggtaag ggaatcgttt tagaagaacc
    18481 atctgttgtg gcgatagaca aaagaacaga ttctgtttta gctgtgggag aagaagctaa
    18541 aaagatgata gggagaacac caggtaatat agtcgctata agacctttaa gagatggtgt
    18601 aatttcagat tatgatgtaa ctgagaagat gttaaaatct tttatagata agatagttga
    18661 taaaaaggga tttggaagat tttttatgcc aagaattatg gtatgtgtac caacaggtgt
    18721 cacagaagtg gaaaaaagag cagtagaaga tgctacgaga caagctggag ctagagaagt
    18781 atatatcata gaagaaccaa tagcagctgc cataggagct ggtgtagaca tatcacagcc
    18841 taatggtaat atgattatag atattggtgg aggtactgta gatatagctg taatatctct
    18901 aggaggagct gttgtaagtg aatctataaa ggttggtgga gatagatttg atgatgctat
    18961 agttaaatat atgaaaaaac aacacaatct tcttatagga gaaagaacag cagagaaaat
    19021 caagtttgaa ataggttctg catttaagag agaagaagaa aaatatatga agataacagg
    19081 aagaaattta attacaggac ttcctagttc tataactata aattcaacag aaatgttgga
    19141 agcacttaga gaatgtgttg agcaaatagt agttgctact catgctgttt tggaaaaaac
    19201 gcctcctgag ttagcagcag atataggaga tgtcggtata ataatgactg gaggaggttc
    19261 attattatat ggattagata aaataataga acagaggaca ggaataactg ttacaatagc
    19321 agatgaacca ttatcttgtg ttgcaaaagg tacaggaata gctttaggtt caatagactt
    19381 acttgaaact ggtgggtctt tcaaaagaaa ataattagga gagtttagaa tgttaaatat
    19441 agatgaaata aaaaaattaa taccacatag atatccattt ttattagtag acaagattac
    19501 agagctagaa gttgggaaaa gagctgttgg tataaagaat gtaacagtta atgagccatt
    19561 tttccaaggt cactttccag aatatccttt gatgccagga gtactaatag tagaagctct
    19621 agcacaagta tgtggagtgg caatgatgtc tgtagaggaa aacaaaggaa aactaggtgt
    19681 atttgcaggt atagataaag ttagaatcaa gagagaagta agaccaggag atacattaac
    19741 tatggaagtt gaaatgacaa ctcttagaaa aaatatagct aaggcagatg ctaaggcata
    19801 tgtaggtgaa gaacttgtct gtaaaggtga attaatgttt gctttagtag aaaaataaaa
    19861 acttgaaata taaaagtaaa aaggtagata atttggagta tttaatcaga tactctaaaa
    19921 tatctacctt tttatataaa gaattttatc atttagttta tatttagatt aggtggatac
    19981 taataaagcc aaggctattg tttcagctaa atctaatata aagctaaggc gtatattatt
    20041 aaatgaaagt ttattatttt catcaatttt atctacaatt cctactatag aataatttcc
    20101 tatttgaggt agttttttac caacaccttt tccgggcagg ataggtcctt ctctaatctg
    20161 tatattacct atgttactct gcgaccccaa gcaagcatct atagccaaga agttaccttg
    20221 tatatgtgta ttttttatag tatctaaaga ctcatatata tttaaggcgt gaatagggtt
    20281 atctagtgta ccgtaaacgg ggtatttaaa gttactgttc ttaagtattg ttccaactaa
    20341 agggcctaaa gtatcaccta tagccctgtc tgttcctatg caaacaacaa tcgtattttc
    20401 attaattata gtttttagaa ctgaacttag catctgtata acatcatcat cgctgtagtt
    20461 tactttagct aaatacaata ggaacacccc cttcaaaaaa atatatgaat aaaaagcatt
    20521 aaaaagacct aactttaaat ttcagataga tagaaaattt tatttgtctt acaaaaaaag
    20581 gaatagaaaa aatatgacta aaaatattga caaaatttta aaaaaatagt aagctagtaa
    20641 agtaaaacaa aacttaaatc ttgattacct tatcaagaga ggctgaggga taggccctgt
    20701 gaagcccagc aaccacccaa atgggaaaag gtgctaattc ctacaagaca aaagtcttga
    20761 aagatgaggt cagttaatta gtatgtaatt acgattatta acctcttctt ataaaggaga
    20821 ggttttttta ttttgagtaa atttctaaaa ttaaaaataa ggtaaaacct ataataaaaa
    20881 ttaagaataa ataaggggga ataaaaatgg caagacattt atttacgtca gaatcagtta
    20941 cagaaggaca tcctgataag atatgtgacc aaatatcaga ttcaatatta gatgcattat
    21001 tagaaaaaga cccacaatct agagtagctt gtgaaactac agttactact ggtttagttt
    21061 tagtagcagg agaaataagt acatctgctt atgtagacat tcctaaatta gtaagagaaa
    21121 cagtaagaga aattggatat acaagagcaa aatatggatt tgattgtgat acttgcgcag
    21181 ttataacttc tattgatgaa caatctggag atatagctat gggagttgat gaaggcctag
    21241 aaagtaagac tggagaagag atagaagaag aaatagaaaa agttggagct ggagaccaag
    21301 gtataatgtt tggatttgca tgtaatgaga ctccagaatt aatgccactt ccgatatctt
    21361 tggcacataa attatcaaga agacttacag aagttagaaa aacaggttta gttgattatt
    21421 taagaccaga tggaaaaact caagttactg ttgaatatga aggaagtaaa gctgtaagag
    21481 tacatacagt tcttatatca gctcaacatt gtgaaacagt atcaaatgat aaaataagag
    21541 aagatttaat taatcatgtt attaaggaag ttataccagc agaattactt gatgaagaga
    21601 ctaaaattta tataaatcca acaggaagat tcgttatagg aggaccacaa ggagatacag
    21661 gtcttacagg aagaaaaata ataatagata cttatggtgg atattctaga catggtggag
    21721 gagctttctc aggaaaagac cctacaaaag ttgatagatc tgctgcttac gcagctagat
    21781 atgttgcaaa aaatattgtt gcggctggtc ttgcagacaa atgtgagata gaacttgcat
    21841 atgctatagg tatagctaga ccattatcta tatttataga tacttttggg acaggcaagg
    21901 tttcagaaga aaaacttgtt gaattagtaa ataaacactt tgatttaaga ccaggagcga
    21961 taataagaga cttagattta agaaagcctc tttataaaaa ggttgctgct tatggtcact
    22021 ttggtagaac tgatatagat ttaccttggg aaagaactga caaggttgag cagttaagaa
    22081 aagatgcttt aggtgaataa tttttaacta aaaagctgtt agaatgtaat tttacgatta
    22141 ctttctaaca gcttttttat tatgagttaa atatttttaa taaatgttaa tttatcatca
    22201 tataatgaat aaacagtatt taatctggtc aatacatttt atataatact ctactaaatt
    22261 tatacatatt atgggatata tgttaaagga tggttaagaa tgtgttaact aatgttaaat
    22321 aattaaaaat atattgaaat atcacaataa tgagtctaat ataatcttaa taaacttaca
    22381 ctttaaaaat aattttaatt gggggggagt agtgtatgtc aggcaaagta aatattaaaa
    22441 cggttataag ttttgctgga gcttatgttg ctactgtaat aggttctgga tttgcaactg
    22501 gtcaagaaat actgcaattt tttacgtttt atggatatgc gggtattata ggtggaataa
    22561 tctctatggt actattttca tggtttggag cagaagttat agataaggga agagaattga
    22621 aacttaagga gccaataaaa atttatcaag tatattgtgg aaaatatctt ggaacatttt
    22681 ttgaatggtt tggtccattg tttttatttg gaacattagt aataatgatt gcaggagcag
    22741 gagctacatt atcagagtac tatggattaa atccatatgt aggtaggatt ggtatggcaa
    22801 tcgtttccct aataactgtt tcattaggtt tgacaaggct ttctaaaata ctaggtaata
    22861 taggacctat aataataata tttacacttt tagtaggagc aattagttta tttagcaata
    22921 ttgatgcttt atcaaatgct ggaaatatgg ttgatagttt aaatattaaa actgctacat
    22981 caaatggata tttctcggga gtactttata cttgttacaa tgtaataata gtaataacat
    23041 tcttgacagg aatgggagct tctgcagtaa ataagaaaga tgctgtatgg ggtggtatag
    23101 taggtggagt agcacttatg gcagcagcta taatgatgaa tttggcatta ctttcagaca
    23161 taggaaatat atacacaaaa gagataccag cactttactt agctgataag atatctccaa
    23221 taataggtat tttattctca gtagtacttt tactaggaat atacactaca gctgtaccat
    23281 tgttatggtc agtaacaaac cgatttgtag aagatgacca ccctaagttt aaaattataa
    23341 caatagtggt aagtatatta gcttgtatag gaggtttact gccatttgat aagttagtag
    23401 gtacactata tccatataca ggttacatgg gaattttaat tttactatgt atgctttata
    23461 gaagaattac taaaactgag gggtacaagg agaataaatc tgaaataagt tagtactgta
    23521 atatacttat gaaatttaat ttatactcta aatatagagt aattaaaata aaatagctat
    23581 ttaaatatgg tacctgtatt tcatggtacc atattttatg gatgcagatt ttttttgttt
    23641 ctgataaaat gtataatagt tggaaattac gttaagtata aaaatataaa acttttctac
    23701 gattatcata gttttaatat ataaaattat actaacattt aaatggagcg attattagta
    23761 tttttaggag ataaaaatgg aaaaattaga aggaatgata agtgaaatag tctttaaaaa
    23821 cgaagataat ggttatacaa tagctcacct ggtaaatgaa aatgatgaaa ttgtggttgt
    23881 aggatgtatg cctactttgg caattggaga aagcatagaa gttgaaggaa agtgggtaaa
    23941 tcataagatt tatgggactc aatttgaagt gaatagtttt atgccagtaa caccatcatc
    24001 cttagaagga atttatgttt acttatcttc tggaatgata catggtattg gtgaaaaaat
    24061 ggcaaaaaga ataattgata agtttggtgt agatacgtta gaggtgatac aaaattcacc
    24121 agaaaaacta caagaagtag aaggcatagg gagtaaaaaa gtaaaacaaa tagtaaaaag
    24181 ttatgaagaa gacagagaat tgagaaatat aataatacag ctatctcctt ttggaataac
    24241 accaaattac tgcctaaaaa tatataaaaa atataaaagc agtgcaatag aagttataaa
    24301 taaaaaccca taccaacttg ctgaagatat aagaggaatt ggatttaaag tagctgatag
    24361 tatagcaagt aaaattggta tagataaaaa ctctaaagat agaatttgtc agggaatctt
    24421 atacacttta aataaatctt taagtaatgg gcatacatat ttaccagagc atgttctaat
    24481 acaagattcg gaaaaattat tggagctaaa tggagaaata ataaaagagt gtgtaatgat
    24541 gctagtttat aatcaaaaaa tacatataga gaaagtaaac aatgaaaatc ttatatacct
    24601 tatgccatac tatttagctg aaaatggagt atgtagtcaa atagtaaaat tatcacagta
    24661 tgaatttgaa gacttaaaaa tagatataga taacgagatt aatgttttag aagaagataa
    24721 gaaaattaag ttagcagaaa aacaaatttt agcagtcaaa gaatctgtta atagtggagt
    24781 attaattata actggtggac caggaactgg taaaacaact accattaatg ctatcataga
    24841 tatatttgaa aataatggta aaagtgtgac tttggcagct ccaacgggaa gagcagcaaa
    24901 gagaatgagt gaaacttcta ataaagaagc aaaaactata cataggttgc tagaaatggg
    24961 attttcaaca gatgatgatt taactttttt taaggatgaa gaagacccaa taaattcaga
    25021 tgtaataatt gttgatgagg tatcaatggt agacattatc ttaatgtaca atttacttag
    25081 agctataaag ttaggaacaa gagtaatttt agttggagat agtgaccaat taccttctgt
    25141 aggtgctgga aatgtactta aggatatgat taattctaat attataaatg tagttaaatt
    25201 aaatgaaata tttagacaag cgcaagaaag tatgataatt gtaaatgccc ataagataaa
    25261 caatggagaa ccactttatc taaatacaaa aggtaaagat ttctttttta taagaaaatc
    25321 aactaatgaa gaaattttaa atgaaataat aggattggtt aatgaaagat tacctaaatt
    25381 ttataaagtt gataaattaa aagatataca agttttatct tcaatgagaa aaggtgaatt
    25441 gggagttact aatctcaata tagagttaca gaagtatctt aacaaaaaag aaaaatttaa
    25501 agttgaagaa agtttttcta aaagattatt tagagttggc gataaggtaa tgcaagtaaa
    25561 aaataattat acaaaaaaat gggaaacaga agaccaaaaa gaaagtggag aaggtatcta
    25621 taatggagat ataggatatg tttatcacat agataaagat aagaaaacta tttatatatt
    25681 atttgaccag actaaaattg tatcatacct atatgatgaa ttagatgaaa ttgaccatag
    25741 tttttgtaca acaatacata aaagccaggg aagtgaattt ccagttgtag tattgccaat
    25801 agcgtgggct cctcctatgt tacttagccg taatttatta tatacagcag taacaagagc
    25861 aaaaaaatta gttgtattag ttggagatgt gaaatatctt gaatatatga taaaaaataa
    25921 tagagttaat caaaggtatt caaatttagg atataagcta aataaattta aacaagaagg
    25981 gttgttgata gaataaatat gaaaatatgc aatgataatt ttattaagaa ttttaaaaat
    26041 atgattaata aatgtttgga ttttatatat cctgagaata taagttgcat aatttgtgat
    26101 aaatccataa agaaaacaaa tacttattca atatgtaaaa gttgttttaa agaaatgaat
    26161 tttatacaag atggttgcat gaagtgtgga aaaccaataa tatgtcattc aattgaaaaa
    26221 gaatttattg aagagtgtag ttattgtttt aataaagact tttattttga taaatcaata
    26281 tcttgtattg aatacaatga tgtgacaaaa aagatggtgt tagggctgaa gtataaccaa
    26341 aaaaccttta tggctaagta tatagctcaa ataatgaaag aaaaattata tttagaaaac
    26401 ataaaatttg attatatatt atttgttcca cttcataaaa aaaggctaaa taaaagaggt
    26461 tttaatcagg cacaaaaaat agcatttaat ttaagtaaaa tagtaaatat tccattatta
    26521 gattgcataa gtagaaaaaa atatacaaga atgctatata aattgaataa gaaagaacga
    26581 aaagaagaat taaaaaatgt atttgttgtt aaagaaaatg ttaaattaat aaataataaa
    26641 aatatacttt taatagatga tatatttact actggtctaa caacaaacga aatttctaaa
    26701 cttttaaagt tatcaggtgc taataaggtt tttgtattga ctctacttac aaaagcaaat
    26761 gataattata ttatggaata atcttatata ttgacaattt tagtttaaaa tattaaaatg
    26821 aataagtgat atttaggtct gtggttgaaa gtccaagcca gtcgcaggca aagggatcca
    26881 cgtaagttaa cactaaaaat tgggttaatg atcatggtgc ggcttagaag taagacctac
    26941 cgataataaa atcgagagag agtagtagtg cggcgaaccc aagcgaaccc tccagtaggc
    27001 gagtgtgggg tcaaaaacca ggtcagctaa atatcatatt aaaagagagc tagcatacct
    27061 ttatgtatag ctctttttta tatataataa atttaggttg agtcataaag aggtgatatg
    27121 tttgaataaa agacaagaaa atttattaac aacattgcta ttaaaagaag agtttataaa
    27181 tgttaataag attgccaatg attttgagtg ttcagaaagg acaataagaa atgattgcaa
    27241 atatattgat gaatggttat ctactttttg taatgcttat atcaaaagaa aacctaatat
    27301 tgggattaaa tttagtggag atggaacaga caaaatactg gtaaatcaga agttgcgagg
    27361 tgaagttaaa agagtaaata gtgagcttca taagcaagtt gagatattaa atttactact
    27421 ttgtaataat aaaaaagtta ctttaaatga tttatctaat aagttgtaca taaataaaaa
    27481 tattgtcaga gaagaaataa gtaaattatc agtagcatta aataattata atttaaatat
    27541 ctcgactaaa aaaggcagtg gtatatatat tgaaggggat gagaaagaca taagaataat
    27601 gttagtatca ttcttattta aatatataga taaatacaga ttaaacatag atgaaataga
    27661 gtacttccat atagtagata taataattgt aaaaaacata atgcttacta tagaggagga
    27721 tatggatata agacttacag atatatcatt caagcaattg atgctatttt tgcttataaa
    27781 tataatacga ataaggctgg gaaattcttt aaaagtatca aatactaaga aagagcttaa
    27841 gctaaaaatg cttatattgg atatagaaga tgaattgaaa tctaatttat ccatagtatt
    27901 aaattatgaa gaaaaattgt ttatagaatc tttaatattg ggtatgaaca aacaaataaa
    27961 tagtaataat attaagaaat ctttatatct aaatgaagaa ttagcaagtt atacaaaaaa
    28021 aattataaat ttagtatcag aagaatcagg aataaatttt aataatgata tattacttta
    28081 tgaacaatta atatgtcatt tgaatgttac aatgcatcaa atgaaaagca atgtttactt
    28141 agaaaatcca cttttagata acataaaaac taaattttgt tttttattta cagtaatatc
    28201 aagttcaata gaaattgaat taaaaggaaa acaaataacg gaagatgaaa ttggttatct
    28261 tacacttcac tttcaaacct ctctagaaag aaaatacagc aaaagggaat caaataaaaa
    28321 ggcaagtatt gtatgtccat ttagttttgg agtaagtatg ctattaaaag taaagataga
    28381 aaagagattt gataacataa aaattattga aacattaaga gaggaagatt taaaaagaga
    28441 taactttaat aagactatag attttataat tgcatttcaa gagtatgaaa atatccaaaa
    28501 accaattttt ataacaacac cattatttac tgatgaggat gagaataaac ttaaagagtt
    28561 cacaaacaaa ataaaagaaa aagacacttc atataaactt atgaacagat taatgatgtc
    28621 tgattattta ataagagagt tagaacatga tgatatttat gaagctataa catatttaac
    28681 taatttatta attgaaaaac attatgcaga aaaagagtat ttacaatcta ttataacaag
    28741 agaaaagtca tatccaacca atgttggaaa aggaatatta ttccctcatg gagacatgaa
    28801 atatataaaa caatctgttt tatgttttgc aaggttaaaa acaccaataa aaattagaaa
    28861 tggaaaggat ataaagatta tacttttgtt agcatataaa aaagatgatg atagaaaagt
    28921 atttagagaa ttatttaaag aaatatctaa tttaacagag gatgaaaata tgctagatat
    28981 tctaagtaaa tgtgacattg aaaaggtaaa agatattctt atataaaatt catagtgaac
    29041 tatggataag cacaaaattt tccatgtgat ggaaaaagtt gtgcatgttt ttttgttttt
    29101 ataagatatt atatgtttgt aaggtataaa taatctaaaa gtagagaagc aacttaggag
    29161 gaaaaaatgg aagaaatagt tttaaagatt ataattcatg ctggaaatgc aaaatctatg
    29221 ctttatgagg cacttgacta tgcaaaggaa aacgatttta aaaaagcaga tgaattaatt
    29281 gaaaatgcaa atgaagaaat tttaaaagca cataaagtac aaactgaact tatacaaaag
    29341 gaagctgggg gagataaatc agatatatct attttattga ttcactctca agaccattta
    29401 atgacttgta tgagtgagag aaaccttata aaagaaatga ttatgttaag aaaagaaatt
    29461 caaaaactaa aataaaaaat taagggggat ttaaaaaatg aaaagaaaag tatatttatt
    29521 ttgtagcttt ggtatgtcaa caagtttact tgcagataaa atgcagaagg tagcagatga
    29581 acacaattta ccaatagaag tagaggcatt tccgatagca gaaattgaca aaatagttga
    29641 agaaaaaaat ccagattgta tattattagg accacaagtt aaatacatgc taaaggagtt
    29701 aaaaccaaag tttgaagctc aaggaaaact tatagatata atcaatgaag ttgattatgg
    29761 aactatgaat ggggaaaaag tattaaaact tgctataaag ctaataaaat ctaaacaagc
    29821 gtagaattat agtaaaaaat aataggaaat gagggtggat agatgaatag attggaaaga
    29881 atacttatgc cattggctga aaaaataggt aaaaataaat tattaattgc aattagagat
    29941 ggttttttag tatcatcacc attattaata ataggttcat tatttttatt agtagcaaat
    30001 tttcctataa aaggatggaa tgaatttgta ggtcaaattt ttggtccaga ttgggctgta
    30061 aaattgcaac aaccaactgt agcaacattt gaagtaatga ctctacttgc agttttaggg
    30121 attggatatt cttatgcaaa gcaaatagat gtagacccaa tagcatcagc agcagttgca
    30181 atagttgcct tttttataat aacaccattt gtaataccat atacaccaga aggaacagaa
    30241 tcagtttaca tggtaacagg tataccacta ggttggatgg gttctaaggg aatgtttgta
    30301 ggtatgataa cagcaataac ctctgtaaaa ttatttgctg cagttgtaaa aaaaggatgg
    30361 acattgaaaa tgccagatgg agttcctcca actgtatcaa aatcatttgc agcattaata
    30421 ccaagtgcaa tagttatggt agttttcttt ttagttaaga tagcttttga agctacacca
    30481 tatggaagta tacatgaatt tatatttaag tttttacaaa tgccattatt aaaattagga
    30541 aatagtttag gtgctatggc aatcgcttat atattcttac atttattctg gttctttgga
    30601 ataaatggaa gtagtgttgt tggggctgtg tataatccaa tattaaaaat tctatcagct
    30661 gaaaacttag ctgcttttca agctggttca aaaataccaa acataataac aggtcaattc
    30721 caagatatgt ttgcgacatt tggtggagca ggtagtacac tatcattagt catagctatg
    30781 ttattaatat gtaaaagtaa acgtataaag tcaatgggaa aactatcaat tttaccagga
    30841 atatttggta taaatgagcc attgatattt ggtctaccaa taatgcttaa cccaatacta
    30901 ttgataccat ttgcaatagt tccaacaata aatataataa tagcttactt ctgtatgtca
    30961 gcaggattag tgcctcttac aaatggagtt cagttaccgt ggacaactcc aattatattc
    31021 tctggttttt taacaacagg atggcaaggt gcagtcttac aattagtact tcttatacta
    31081 ggaatattta tgtatatacc atttataaaa atgctagata agcaatactt gagagaagaa
    31141 aatgaaactg ttgaagagga agatgatgat atatcttttg atgatttagt attataggag
    31201 gaagattatg aagaaaatag ttatgatatt ggaccaaata caagctggag ctggaggaaa
    31261 agagaaaagt aatatacctc ctgctggaaa atcaagccca ttaggaccag gtgtaatgat
    31321 ggagcaattt ttaaatgaat ctaaggtaat agctacctta ttttgtgggg atgaattttt
    31381 tgtaaataat caagaagaag taacgagtaa gatgatagct atggtaaaaa aattaaaccc
    31441 tgatgtagta atctgtggac caagctttaa ttacgaaaac ttttctaaga tgtcagcaat
    31501 actgtctaaa aatataaatg ataaaacaga tataccagct tttgcagcta tgtcagaaga
    31561 aaatatagat gtgataaacg aatataaaaa tgacatatgt atagttaaga ctccaaaaaa
    31621 aggtggaatt ggtcttaatg attcattaaa taacatatgt aaattggcaa aagcaatagc
    31681 aaataaagaa gatataactt tgatgaaaga agagttttgt tatcaataag agtattaatt
    31741 attagcaagt ttaaatatta tactatttat aataagcata cattagtaaa atctatataa
    31801 tttaaggagg ggaattttaa catgtgggga atgatagcga catggagaat ggccctagaa
    31861 ggaataactg aggcatcaga acatttagaa aaaggcatgg aagcaggtga tgctgtagag
    31921 cttgctgtaa gaagagttga agactatcca ttctataaat cggttggata tggtggactt
    31981 ccaaatgaaa attgtgaggt agaacttgac gctgcattta tggatggtaa cacattagat
    32041 attggcgcag ttgctggtat aagagattat tctaatcctg tcagcatagc taggaagtta
    32101 agttatgaga aggtaaataa ttttttagtt ggaataggtg ctgaagatta tgctcataaa
    32161 aatggatttg aaagaaaaaa tatgttgact gatagagcga agttacatta taaaaagaga
    32221 aaaaaagaga ctttagacaa aggattaagc ccatatgctg gtcatgatac tgttggtatg
    32281 atatctttag acaaaactgg aaaaatgtgt gcagctacat caacaagtgg attgtttatg
    32341 aagaaaagag gtagaatagg agattctgca ctatctggtt caggattcta tgttgatagt
    32401 agtataggag gagctacagc tactggtttg ggagaagatt taatgaaggg atgtatatct
    32461 tatgagatag ttagacttat gaaagaaggg aagcatccac aagaagcatg tgatattgca
    32521 gtaaatgaac ttgataaaca gcttatcgaa agaagaggaa aagctggtga tttatcatta
    32581 gttgccatga ataataaagg tgaatgggga gtagctacaa atatagctga ttttactttt
    32641 tcagtagtaa ctaaagaaga atctcctact gtatatattt caaatagagt agatggaaag
    32701 actatacata aggttatatc aaatgagtgg atggaagcat atgaggctag aataaaagca
    32761 ccaatagaag taagtgagta aagtagtggt tacataatta aaatagagtt ttataataag
    32821 gagattttta tgaatatcat aagtaataaa atagatgagt taaaagaaga tttattaagt
    32881 gatattatag atattgtaaa aatacctagt gtcaaagggg agtcagaaaa tggcttccct
    32941 tttggcgaaa aagtagggga ggcacttaat aaagcattag aaatatcaga aaaattggga
    33001 tttaaggtta gaaacttgga taattatatt ggttatgcag agcatggaga tagtgatgat
    33061 tatgtttgtg taattggaca tgtagatgtt gtacatgaag gagatggttg gaagcatcag
    33121 ccttataagg gagaagaaac taatggaaga atttatggac gaggagtact agacaataaa
    33181 ggacctataa tgtctgcctt atatggatta tatgctatta aagaattaaa cttaaaatta
    33241 gataagagag ttagaataat atttggtaca aatgaagaaa gtggatttga agatatacca
    33301 tattatttag aaaaagaaaa agcacctatt atgggattta caccagattg taaatatcct
    33361 gttgtatatg gtgaaaaagg catggcaaag attagaataa aaagtaaaat caattatgaa
    33421 gaagatgtat acctaggttt tatagaaaat atgtctgaaa atgtgcttgt tacatataaa
    33481 gagctgaata tagaaaatag tgatactata ttagatataa aggtaaaata cgattttagt
    33541 tataaattga aagatgtatt ggatgaaata aaagctagtt ttccaaatag tatcgatata
    33601 gaggtaattt ctaattttaa tcctgtatat tttgataaag agagtaatct tgttaaaaag
    33661 cttcagctag cttatgaaag ggttacatca ttagatggaa ctcccgtaac aactaatgga
    33721 ggtacgtatg caaaagtaat gccaaatata gttccgtttg gaccttcatt tccaggacaa
    33781 aaaggaatag ctcataatcc tgatgaatac atggatatag aagatataat attaaatgca
    33841 aagatatttg caaatgcaat atatgaatta gcaaaggagt agttatgtta gaaataatag
    33901 gaatgtcagt agaagacgct aaaattatag aagattgtgg tgcagataga atagagttag
    33961 ttagtgcttt aactgaaggt ggattgacac caagttttgg tcttatagaa agtgttgtta
    34021 acagtgtaaa gatacctgtg aacgtaatga taagacatca tgcgaaaagt tttgtataca
    34081 gtaaagaaga tataagtata atgcaaaaag atataggtgt ggttaaagag attggtgcta
    34141 atggagttgt atttggtgta ttggataaaa acaataatat agatgagaaa aatctaaatg
    34201 ttttattgaa atgttgtgat aatcttgatg ttacatttca tagagccata gatgaatcaa
    34261 atacaataga tagtgttaaa attttgaagg attatgataa aattacgaat atattaacat
    34321 caggagggaa aggaagtata gttgataaca tacaaatgat aaagaatatg atgcttagtt
    34381 ctaatcacat aaaaattctt ttaggtggag gtcttaattt taataatata gaaaagataa
    34441 aggaattgac taaggcaagt aattttcatt ttggtacagc gattagaata aataacagtc
    34501 cttttgaaga tatagataga caaaagctta aacaactcgt aaatataatt tcaagatagt
    34561 atatgaatat aaaatactta gtttaaataa agagagtaag ttaattataa tttgggtata
    34621 tgaatgttaa taggtattaa atatgaaatt attgttgagt atgctttata acttttaagt
    34681 agttttaaat ataaataatg aaagaaaaga tagattatgg aggttttaga gggtttatat
    34741 ttattaaaaa attataaagg tatattggca tataatacac ataatttcct aaaattacca
    34801 tcttatgaca tgaattcaca tattaataaa caattaatgg agatttttgt ggatagaaat
    34861 aggagtaaaa atagctttaa ataaacaaaa acaagagtta ttaacagttt tatccacatt
    34921 atccacaggt gtttgtaata atattaatcc acataagtat caatgtaact aaaaatgata
    34981 aataattcta tcaattgaat agaaaaaatc ataaaagtaa ataataaaaa gaggattatg
    35041 agagttcgtg tagaatatat tattaaagta taaattttct tatactggca taattgaagg
    35101 gagatgtatt tatgaacata attatatctg gaaaacaaat cgaattaact gatgcaataa
    35161 aaaataaaat cgaaactaaa ctaagtaagt tagataatta cattcatcca gacactgatg
    35221 taaaagttac agtaagtgcg agaaaagcaa gacaaaaaat agaagtaaca atagctactg
    35281 taaatggtcc tataattaga gcagaagata tgcaggaaaa tttatacaca gctatagatg
    35341 ttgtatatga taaattaagt aaacaattaa aaaaatataa aaagagatta caagataaac
    35401 ataaagacaa caagagtata agattccaag atgcagagat aaatctagct gatgaacaag
    35461 aggattatgg ggatgaaaat caagaattag taattcaaag acgtaagaaa tttagtgtta
    35521 agccaatgag tgaagaagaa gctgtattac agatggaatt aataggacat gatttttata
    35581 tgttcaagaa catagattca gatgaaatag cagtagttta taagcgtaat aatggtggat
    35641 atggtataat agaacatgaa taaagcaatt tagatttaat catattagct atcgataaat
    35701 aaattatcga tagcttttta aattaatatt aaaagtatag tttttatggt aaaatgaata
    35761 atagtacaat aaagaacgag gagagatgta aaatatgagc tttatggata atttattcaa
    35821 catggcagat aaaaaagaat taaaaaagtt caataaaact gttgatataa tagattcatt
    35881 agaacctaaa tttgaatcta tggcagactc ggaacttaaa aatatgacaa atatatttaa
    35941 agaaagatta gcaaatggtg aaagtataga tgatatactt ccagaagctt ttgcagtagt
    36001 tagagaagtt tctaagagag tgttaggact tagacactac agagttcaaa tgattggagg
    36061 tatagtacta catcaaggaa gaatagcaga aatgaaaaca ggtgaaggta aaactttggt
    36121 tgcaactgct cctgtttatt tgaatgcgct tactggaaaa ggtgtacatg ttgtaacagt
    36181 aaatgattac cttgcaaaac gtgatagaga ccaaatggca aaaatctatg agtttttagg
    36241 aatgagtgta ggcgttatta tacacggtca aaatccaaaa gttagaaaag aacaatatga
    36301 ttgtgatata acttatggta caaataatga atatggattt gactatctaa aggacaatat
    36361 ggtaatacac aaagagcaaa gagttcaaag aggattaaat tatgctatag tggatgaggt
    36421 tgactctata ctaatagatg aggctagaac accacttatc atatctggac ctggagacaa
    36481 atcaactcac ttatattcag atgcaaacac atttgtttta accttaaaac cagatgatta
    36541 tgaattagaa gaaaaagata aggctgtatc tctaacagca tcgggtatac aaaaagcaga
    36601 agtgtatttt aatgttgata atataacaga tatatctcat acagaattat accatcatat
    36661 aaatcaagct ttaagagcac atgtaataat gaagaaagat gttgattatg ttgctaaaga
    36721 tggagaaata gtaatagtag atgagttcac aggtagactt atgtttggta gaagatattc
    36781 agaaggttta catcaagcaa tagaggctaa agaaggtctt aaaatacaaa gagaatctaa
    36841 aacactagct actgtaacat tccaaaatta ctttagaatg tacaaaaaac tttctggtat
    36901 gactggtaca gcaaaaacag aagaagaaga gtttaaagca atctacaaaa tggatgtttt
    36961 ccaagtacct actaataagc ttatgataag ggaagactta ccagactgtg tatacaaaag
    37021 tgaaataggt aaatttaatg ctgtagcaca agaaataatt gaaaggcaca aagtcaatca
    37081 accaatactt gtaggtacag tatcaataga aaaatcagaa ttattatcac aaatactaaa
    37141 gaaaaaggga ataaagcacg aggtattaaa tgctaagcat catgataaag aggcagaaat
    37201 aatagcacaa gctggtagac ttggagctgt tacaatagct actaatatgg ctggtcgtgg
    37261 tacagatata gttctaggtg gaaatccaga ctttttaact aagagagaaa tgagaagaaa
    37321 tggatttaaa gaagaaatag taaatagagt agatactcca atagaaggta tacctgtaaa
    37381 aggtaatgaa attctatttg aagctagaga agagtatgaa aaactatttg aaaagtttaa
    37441 gcaacaaaca caagaagaac aaaaacaagt tgtagaagca ggtggacttg ctataatagg
    37501 tacagaaaga catgaatctc gaagaataga taaccagttg agaggtcgtg ctggacgtca
    37561 aggtgaccca gggagttcaa gattctatat aggtcttgat gatgacctta tgagattgtt
    37621 tggtagtgat agaatatctg gtattgtaga taaaataggt cttgaagaag acatgccgat
    37681 agaacataga atattatcta agtctattga aggagcacaa aagaaagtcg aaggtaaaaa
    37741 ctttggaata agaaagcatg tacttcaata tgatgatgtt atgaataaac aaagagaaat
    37801 aatatatgca gagagaaaac gtgtattaga aggtgaagat ttacaagaac aaatacaatc
    37861 aatgactcat tctataatag aagaagcagt tactctttat acacaagata aaggatttga
    37921 tgaagaagga ttcaaagaac atatgtataa tttgttcttg ccaaaaggta gcatagaaat
    37981 accagaaata gaaaaactta atccagttga aataacagaa aaagtttatg aaatagctat
    38041 gaagatatat acttcaaaag aagaacaagt tggctatgag agaatgagag aagttgagag
    38101 agtaatctta cttcaagctg ttgataacca ttggatagac catatagatg ctatggacca
    38161 attacgccaa ggtattggtc ttcgtgctgt aggtcagcaa gacccagtta ttgcttataa
    38221 aatggaaggt tttgatatgt ttgatgaaat gaataaacat atcaaagaag atactgtaag
    38281 atatttattt aatataacaa tagaaactcc agtggaaaga aaagcagttg tagatgttga
    38341 aaatctatct tctccatcag atggaacact tccaacaagt aaaactgtta aaaaagatga
    38401 aaaggttgga agaaatgact tatgcccttg tggaagtggt aaaaaatata aaaactgttg
    38461 tggaagataa tctcggagga ttaaatgtta aagttacaag agtatagaca tagtatggag
    38521 cagatggctt caaatttaga agaattgagg gtttctcttt gacatagctt cattgatgaa
    38581 aaatatacaa attaatgaag aaaagatgaa tcaacaagat ttttggaatg ataatgaagt
    38641 cgctcaaaga gtacttcaag aaaataaatc tttaaaagag acattagaag aatatgaaag
    38701 cttaaaaagc ttattagaag atatagaagt attaattgaa ataggtttag aagaagataa
    38761 tgattctgta gaaagagata tagaaaagtc catagaatca atggaagaaa aattatctga
    38821 aatgaaaata aagactcttc taaatggaga gtatgataaa aataatgcta tattatctat
    38881 aaatgctggt actggtggct tagatgctca agattgggct caaatgcttt tgagaatgta
    38941 tataagatgg tcagaaagta agggttataa agttaagctt ttagatataa tatcagaccc
    39001 tgaagcaggg ataaagacag ctacaattct tgtagaagga acaaatgctt atgggtattt
    39061 aaagagtgaa aaaggagttc atagattagt gagaatatct ccatttgacc catcaggaaa
    39121 aagacatact tcatttgcat ctatagatgt aacaccagag ttagatgaaa atatagaagt
    39181 agaaattaat ccatcagatt taaagataga cacatataga gcttctggag ctggagggca
    39241 acatgtaaat acgactgatt cagcagttag aataacacat atccctactg gtgtagtagt
    39301 tcagtgccaa aatgaaaggt ctcagcatct aaataaggac agagctatga gacttttaat
    39361 ggcgaaattg atagaattaa aagagttaga gcaaaaggaa aaaatagaag atatacaagg
    39421 caaatactca caaataactt ggggtagtca aattaggtca tatgtttttc aaccatataa
    39481 attggttaaa gaccatagaa caaatgctga gtttggaaat gtagatagtg taatgaatgg
    39541 aaatatagac ttgtttatta atgaatactt aaaaatgaat aaaatagttt aataaatatg
    39601 cactgtaatt aagatatatg tataagaagg ttagtgctta atatgcactt acagcactta
    39661 ggctgaggac gataaccctc agccttcgtt ctgttttgtt atacttatga aaaactaaca
    39721 ttaggagtga ataaattgga tataaatcaa atcttaaaaa aagagtttaa tcttagagat
    39781 gaacaaataa ataatacatt aaaacttatt gatgaaggaa atacaatacc atttatagct
    39841 agatatagaa aagaaatgac tggcgaaatg agtgatgtta cactaagaga attttatgaa
    39901 aaattaatgt atttgagaaa tcttcaaagt agaaaagatg atgtagttag actaatagat
    39961 gaacaaggga aattaacaga tgaaataaca caaaatatag aaaaagcaaa aacattacaa
    40021 gaagtagaag atatatatgc tccatataaa caaaagaaaa gaactagagc aacaatagca
    40081 aaagaaaaag gattagaaaa tttagcattg tcaatactag agaataattt agataatata
    40141 gaaatagagg caaagaatta tcttgatgaa gagaaagaag ttctttctat tgaagatgct
    40201 ctaaaaggtg ctagagatat aattgcagaa ctagtctcag atgatgctaa gattagaaag
    40261 tatataagag aattagcttt aagagaaggt atgatagtta gcaaaagtgc tactgatgag
    40321 aaatcggttt atgatatgta ttatgattat agcgaagcag taaaaagtat ggctccacat
    40381 agagttttgg caataaacag aggagaaaaa gaaagcttcc taaaggttaa gttggaaata
    40441 aataatgata aagttttaaa ttacataata aacgaatatg taaatgataa aaatttcaaa
    40501 aataaagaag aaatcgtaag ttcaatagaa gattcttata aaagattaat tttcccatca
    40561 atagaaagag aaataagaaa tcatttaaca gaaatagctc aagaaagagc tataagtgta
    40621 tttggaaaga atgttaaaag tttattgctt caaccaccag ttaaagacaa agtagttatg
    40681 ggatttgacc ctgcatttag aactggatgt aaaatagctg tagtagataa aaatggtaaa
    40741 ctactagatt atacaacagt atatccaaca gaccctcaaa atgatgtaga gggagcaaag
    40801 aaagttttaa aaggattgat tgaaaaatac gatatagata taatttcaat tggaaatggt
    40861 actgcatcta gagaatcaga aacttttgta tcagaaatga taaaagaaat agatagcgaa
    40921 gtgcagtatg tgatagttag tgaagcagga gcatctgttt attcagcatc tgaacttgca
    40981 aatgaggaac atccagatat aaatgtatca ataagaggag ctatatctat agctagaaga
    41041 ttacaagacc cattagcaga gcttgtaaaa atagacccta aaagtattgg tgttggtcaa
    41101 tatcagcatg atttaaacaa aaagagatta gaagaagtac tagatggagt tgttgaagat
    41161 tctgtaaata gtgttggagt agatttaaat actgcatcat actccctact agaacatgtt
    41221 gcaggaataa gtaaagctat agcaaaaaat ataatagcat atagagaaga aaatggagat
    41281 tttacgtcaa gagcacaatt gaaaaaagta aaaagactag gacctcaagc atttactcaa
    41341 tgtgctggat ttatgagaat cttagagggt aaaaatccac tagataatac aggtgtgcat
    41401 cctgaaagtt atgatatatg taaaaaaatg attgagataa ttggatattc tttagatgat
    41461 gtaaagaata agaatatagg tgaaatagat gaaaaaataa aagaaattgg cttgagggaa
    41521 ttaagtgaaa aactggaagt aggacaagtt acgttaaaag atatcatagc tgaaatcaaa
    41581 aaaccaggaa gagacccaag agaagaaggt ataaaaccta tacttagaac tgatgtctta
    41641 aaaattgaag atatacaaga gggtatgact ttaaaaggta caataagaaa tgttgtagac
    41701 tttggtgcat ttgtagatat tggaataaaa aatgacggat tagttcataa atcagaaatg
    41761 agtaatagtt ttgtgaaaga ccctatgagt attgttacag taggtgatat agtagatgta
    41821 aaagtcattg gaattgactt aaacaaaaaa agagttgcct tatcaatgaa aaaatagata
    41881 agtttatgta tggttatagt acttagattc tatatttgta aataagatta ctcgagtgta
    41941 taaatgttaa aaatttgtaa aagtatatag taagaaaata tattaaaata agaacgatag
    42001 tcttgaaaat caggaggaaa atgaatgatt tttataaaaa atggtaaaat aaataccata
    42061 acaaatggga taattcatgg agatatactt atagatgaag gaaaaataat agaaattgga
    42121 gaagatttga tagctccttt agatgtagag gtaatagatg ctagtaataa acttgtgttt
    42181 cctggattta tagatgctca tactcactta ggtttatggg aagatggtat agggtttgaa
    42241 ggagcagatg gaaatgaaga gactgaccca ataacaccac aattaaatcc tatagatgga
    42301 attaatccaa tggatagaac ttttaaagaa gcttttgaag gtggaataac ttctgtttgt
    42361 acaacccctg gaagtgcaaa tgttatgggt ggtcaatgta tagctataaa gacatgtgga
    42421 aaaagaattg ataaaatggt aataaaaaat ccagttgcat ctaaaattgc ttttggagaa
    42481 aatccaaaga gctgttatgg tcaggatgat aaatctcctc aaactagaat ggctatagct
    42541 gctttactta gagaaaacct aaaaaaagca gaagaatatt tagaggatat tgatatgtat
    42601 gagagtcatg atgatgaaga ctgtgaaaaa cctgaatatg atataaaaat ggaaagttta
    42661 ataccagttt taagaagaga aattcctttt aaggcacatg ctcatagagc agatgatatg
    42721 tttacagcaa taagaattgc aaaagaattt aatttaaagc ttacattaga ccattgtaca
    42781 gaaggtcatc ttattgtaga tgaattagtg gaagaagggt ttcctgtaat agtagggcca
    42841 tctttgtcag aaaggtctaa atttgagctt agaaatttga catttaatac agcaggaata
    42901 ctttcaaatg caggtcttga tgtatgtata atgacagacc atccagtaat accagttcaa
    42961 tatcttccaa tatgtgcagg tattgcagta aaacatggta tgaaagaaga aaaagcaata
    43021 gaatcaatta cgataaatcc agctaaggct ttaggaatag aagatagagt aggctctata
    43081 gaagttggta aagatgcaga cctagtaatt tgggataatt ctccactaga gattcaaagt
    43141 aatgtacttt acactataat aaatggcaaa gtagtgtatg agaaaaaata acttgacaat
    43201 tattaaaaaa ttaactaata taagagtgta aggaaaatta aaaaatcaaa gaagatcttc
    43261 ggggcagggt gaaattccct accggcggta tagcccgcga actacttagg tggttgattt
    43321 ggtgagattc caaagccgac agtaaagtct ggatgagaga agatatttat ggaagataaa
    43381 taagtttatt ttagtttgtt taaactatat ccataaaaac tcgaagatag ggtcttcgag
    43441 ttttttgttt ttcctaaaaa atataaacat attgattagg gggaaaataa ttatgcaaaa
    43501 cacagcaaaa agaggcaata tgatttcaac aagaacttta gtagtaatgt caattttatc
    43561 tgcaatatct tatttattaa tgtttattca agcaccaata ccaggtatat ttccagattt
    43621 cttaaaaatt gacttatcag atattccagc aatattcgga ggaatgtctc taggaccatt
    43681 agttggattt ggaatagttg tagtaaaaaa tgtgttacaa gcaataacag caacaacaac
    43741 tggaggaata ggagaatttg caaatatatt aattggtggt tcttatgtaa tgatactttg
    43801 ttattcatat aagagaagtg gagatttaaa aggtgtactg attggttttg tattaggaac
    43861 aatatctatg actataattg gttcattagt aaattatttt gtaatgttgc cactttatgg
    43921 tcaacttatg ggactagatg ctataatagg tttaggttca gctataaatc ctcaagttca
    43981 tgatttattc acttttgtaa tttggatgat agctccattt aatgtgctga aggctgttat
    44041 aatatcttta gtaacattgc cactttataa aaaaatggga aatataataa agaaataatt
    44101 agacaagaaa atataaaatt aaatgtattg aatagccata atttatttat aacttcagtc
    44161 ctatattgtg attgatatat taaatatatt atggctttat taatttatca aaaaatgtat
    44221 ataaaataag aaatatttag acaaatttaa attttaaaat aaaggaagaa ttaaaacgat
    44281 taactattaa aatatgaaaa aggtatctac aatatacaga gcgaatttat aataaacaaa
    44341 aaataaagtt attattaaaa aactataaag attaataatc aaacttttaa taataactaa
    44401 tttaataatg ataggggtgt atattcatgc atttatctaa aaaaataaaa aaattatttt
    44461 tagatgataa agggtattat tttaatagta attggaaaga tattcatatt ggtatttatg
    44521 atacaaaatt aggagattct ttaaagtata tcactaatga atatattgaa aatatggaaa
    44581 gggtaaaata cgattatcgt gaattaaaaa atatagaaaa tcaaactgat ggtatgtgta
    44641 ttttagcaat aaggcagaat tacaaggcat tagagtatgt aaaaaatcaa accgaagaat
    44701 tatgtttaga agcaataaag tataattata aagcacttga atatgtaaaa gaacaaacag
    44761 aatacttgtg tcttgaagct ataaaaaaag attgtaatgc acttaagtat gtacgaaata
    44821 aaacagaagg gcttattata aaagcaataa gtcattcttc caatatagat gttgtaagta
    44881 tactaaaggc tttagagact caaacaagaa ggatatgttt agaagcaatt aaaaaagatg
    44941 gcaggtgtct tgcatacgtt agagaacaga gtgaagaatt atgtatagag gccattaagc
    45001 aaaattataa agcattaaaa tatgtaaaaa atcaaacgga aaaaatgtgt atagaatccg
    45061 taagacaaaa tggtatggca ttacaatatg taaataaaca aactgataaa atatgtatag
    45121 aagctgtcaa acaagatgga agaagtctac aatttgtcaa caataagaca gaagaaatat
    45181 gtataaatgc tataagatat ttaaataaaa aatataatat taaagatgta ctaagttaca
    45241 tagataagta tacagaagat atatgtatag agattgtaag acaaaatgga aaaatgctta
    45301 tgtatataaa aaatcaaaca gaaaaaatgt gtattgaagc agtaaaagag aactataagt
    45361 ctcttaagta tgtaaaagag caatctgaga gaatatgtaa agaagcattg aagcaaaacc
    45421 ataaagcaaa agagtatgta aaaattgcta ttgatgattg tatataaggt gtagatacag
    45481 ccatcaatag tgaaagataa aaaaagataa agacaagtac tttataataa tctaggctta
    45541 tactataatt aattaagcag tgatataaat tcacatgacg attatatcaa aatggagatg
    45601 aattgatggc aaaaatatat ttagaaaatg aaaataaaac tagagaaata ggatataaat
    45661 taggtaaact tttaaaagaa ggcagtgtta tctgtttagt aggagattta ggagctggta
    45721 aaactacaat gacacaaagc ttggcagatt cattagggat agaagattat ataacaagtc
    45781 ctacttttac tataataaat gaatatgaag gaaaaatacc tttgtatcat tttgatgttt
    45841 atagaatagg tagtagtgat gaaatgtatg atattggtta tgatgaatat gtaaattcaa
    45901 atggaatctg tataatagaa tgggctaatc taatagaaga tatacttcca aaagaatatt
    45961 tgaatataga attgagatat aaagatgaag gaagagaaat gatattaact ccaaaaggag
    46021 agttttataa agagatagtt gaggagttga ttaaataatg aaaatactag gtatggatac
    46081 gtcttctatg gcagcaagtg tagcagttgt tgaagatgat aacttaatat gtgagtttac
    46141 agtaaacaac aaaaaaactc attcacaaaa gcttatgcca atgatagaaa atatgttgag
    46201 tatgagtgat ttaagtataa aagatatgga tttattagct gtatgtatag gtccaggttc
    46261 gtttacagga cttagaatag gtatggctac agtaaaagct atggcccatg taaataatat
    46321 accaataata gcagtaaatt ctttggaatc tctagcaaat aacataaatt tctgtgatag
    46381 aaagatatgt tgtatattag atgcgcagaa aaatcaagtt tattcagcta aatacaagtt
    46441 tgaaaatgga gagatgatag aattagatgg tgttgatgtt gtagagtttg atgctttagt
    46501 agatgaaatt gtatcaacta atgaagaatt tataatagtt ggagaagctg tatacaaata
    46561 taaagacaag ttagagaata taaaaaatat aaaaatacct tcaccagcta ataatgtatc
    46621 taacgcagga agcttatgct ctttagcatt aaataaatat aataaaaata tagatgtaca
    46681 tacttgttat acgataaatc ctatgtatat cagaaaatct caagctgaag tacaatatga
    46741 tgaaaaaatg aagaggctaa ataatggaag ataatacaaa actaatagta gatgatataa
    46801 aaatagaaga aatgactaca gaagatatag atgaagtttt tgaagtagaa aaaaattgtt
    46861 ttgaagatta ttggtcaaaa gagtctttta gaaaagagtt gtctaatgaa gtagcaaggt
    46921 atatagtagc taagttaaat ggaaaaattg tcggatatgt gggaatttgg cttatacttg
    46981 atgaagggca tataaataat gtggctgttc atagtgacta tagagggaaa aaaatagggg
    47041 acaagttgat aaaaggcata gttgatttat gtaaagataa taatattgca tctatgacat
    47101 tagaagttag agcatcaaat aaaatagcac aaaatttata tagaaaatat ggatttaaaa
    47161 tgggtggaat aagaaaagaa tactacagtg ataataaaga agatgcaatt ataatgtgga
    47221 accaattaaa agaggtgtag agtttatgag tgatataata acattagcta tagagagtag
    47281 ttgtgacgaa acagctgcat cagttttaaa aaatggtaga gaagtacttt caaacataat
    47341 ctctactcaa atcgagacac ataaaaaatt tggtggtgta gttccagaag tggcctcaag
    47401 aaaacatgtg gaaaatattg atatagttgt tcaagaagct ttagacaaag caaatatagg
    47461 ttttaatgat atagaccata tcgcagttac atatggacct gggctagtag gtgctttatt
    47521 ggttggtcta tcttatgcta aagcacttgc atatactttg aatattccac ttgtaggagt
    47581 aaatcatata gaagggcatc taagtgcaaa ctatatagag cataaggatt taaaacctcc
    47641 ttttataaca ttaatagtat ctggaggtca tactcacttg gttgaagtaa aagattatgg
    47701 caagtatgaa attttaggaa aaacaagaga tgatgcatct ggagaagcat ttgataagat
    47761 ttcaagagct atgaatttag gctatccagg aggtcctatt attgataatc tggccaagaa
    47821 tggaaataaa catgctatag aatttccaag agcctattta gaagaagata gctatgattt
    47881 tagttttagt ggattaaaat cctctgtatt aaattatcta aatggaaaaa gaatgaaaaa
    47941 tgaagaaata gtagttgaag atgtagcagc atctttccaa gaggctgtag tagaggtttt
    48001 atctactaaa gcactaaaag cagtaaaaga caaaggatac aatatcataa ctctttctgg
    48061 tggggttgct tctaattcgg ggcttagagc taaaataaca gagcttgcta aagacaatgg
    48121 tattactgtt aagtatcctc ctctaatttt atgcacagat aatgcagcta tgatagggtg
    48181 tgcaggatat tataatttta taaatgggaa aacgcatgat atgagtttaa atgcagttcc
    48241 aaatttaaag ataaatcagt agagttagat gaatttgtaa atataaaagt attgtttcaa
    48301 aaaagtaagt agaagtgaaa ttaaatataa taaaaataaa tatagtatat attaaaactt
    48361 gaagtaaaac tatttataat ctttatattc caatgaattg caacaaattt taggatatac
    48421 agattgtctt tggcttagat ttgcttcaag tttaattttt tctatagaaa gattatttta
    48481 aaaagtgggt aatataccct tttttttcat tcttaaaaag ttttatacta attatagaaa
    48541 gattaaggag gggaagaaat gagtcaaagt aaagaagaca aaataagaag tattttggaa
    48601 gcaaaaaata ttaaatcaaa ttttcaaaat aaagaaaatt taagtgaatt taatgaaaaa
    48661 aaagcaagta aaagagcaga agacttatta gatgtatatt ataatacatt atctactgct
    48721 gatatggaat ttccatattg gtataataga gaatatagaa aatcagatgg tgatatacca
    48781 gtagttagaa gagctaaagc tcttaaagct gctttttcac atatgacacc aaatataata
    48841 cctggtgaga aaatagtaat gcaaaagaca cgccattata gaggttcttt tccaatgcca
    48901 tgggtaagtg aaagtttctt tgttgctcaa ggagaacaaa tgagagaaga ggcaaagaaa
    48961 ttagccagta acacagctga tgaacttaca aaatttgggt ctggtggagg aaatgttact
    49021 gaaagttttg gaaatgtcgt ttcaatagct ggtaaattcg gaatgagaaa agaagaagta
    49081 cctgtacttg taaaaatggc aaaggaatgg gttggaaagt ctgttgaaga tttaggtttt
    49141 cactatgaaa aaatgatgcc agattatgat ttaaaagaaa acctaatgag tacacttata
    49201 tgcatgtttg attcagggta tacacttcct caaggtagag aagttataaa ttatttttat
    49261 cctttaaatt atggattaga tggaattata gaaatggcaa aagaatgtaa aaaggcagtt
    49321 gcaggaaatg catctggaga tgggcttatt ggtatggacc gtctatattt ttatgaggct
    49381 gttattcaag ttattgaagg attacaaact tggattttaa attatgcaaa acatgcaaaa
    49441 tatttagaaa gtatagagac agatttagaa gctaaaaaag aatactcaga tttagtgcag
    49501 atattagaac atattgcaca taaacaacct cgtacattta gggaagctct tcagttgact
    49561 tatacaattc atatagcatc agtaaatgag gatgctatat ctggtatgtc tataggacgt
    49621 tttggtcaaa ttttatatcc ttggtatgaa caagatatag aaaaaggact aattacaaaa
    49681 gaagaggtta tcgaattatt agagctttat agaataaaaa tcacttgtat tgactgtttt
    49741 gcttcagcgg gcgtaaatgg aggagtacta tcaggcaata catttaatac tttatctata
    49801 ggtggattaa aagaagatgg ttctacagga gctaatgaac tagaagagtt attattagaa
    49861 gcaagtatga gatgtagaac tcctcaacct agtttaacta tgctatatga tgaaaagctt
    49921 ccagaagatt tcttaatgaa agctgctgaa tgtacaaagc ttggttctgg ttatccagca
    49981 tgggtaaaca actcaaatgg aacaacattt atgatgaaac aatttgctga tgaaggtatg
    50041 actgttgaag aagcaagagc atttgcatta ggtggatgtt tggaaacgtc tccagggtgt
    50101 tggaaacagt taactttaaa cggaaaaaca tactctattg caggtggagc aggtcaatct
    50161 gctggctctg gagttcactt tatagctaat ccaaaaattt tagaacttgt tcttatgaat
    50221 ggtaaagact atcgtatgaa tatacaagta tttgagcctc ataataagcc attagatact
    50281 tatgaagaag tcatagaagt atttaaagat tattataaac aagcaataaa tgttttagaa
    50341 agagcaaata acattgagtt agatatatgg agaaaatttg atacttctat aataaattca
    50401 ctactaaagc cagactgttt agacaaaggt caacatatag gaaatatggg atatcgttat
    50461 aatgcaacat taaacgtaga aacttgtggt actgttacta tggtcaattc atttgcagct
    50521 cttaagaaac ttgtatatga tgacaaagca tttacaatag aggaaatgaa ggatgccata
    50581 ttaaataatt ttggatttaa agatgcatta gaagtaggaa attattctat ggcggaccaa
    50641 gtaaaagtag ataagactgg taaatatgat gctatttata aggcctgtct tgatgcacct
    50701 aaatatggaa ataatgattt gtatgcagat aatattctta aaaactatga ggtatggtta
    50761 tcaaaagtat gtgaagaagc acaatcttta tatgctaaga agatgtaccc ttgccaaata
    50821 tctgtttcta cacatgggcc acagggagct gctaccttgg ctactccaga tggtagacta
    50881 agtggaacaa catattcaga tggttcagtc tctgcatatg caggaacaga taaaaatgga
    50941 gtatatgcat tatttgaatc tgcaactatt tgggaccaag cagtagttca aaattctcag
    51001 atgaatttaa aacttcatcc aactactata aaaggacaac aaggaactaa aaaattatta
    51061 gatttaacaa gaagttattt aagaaaaggt gggttccata ttcaatataa tgttgtagat
    51121 tcagaaacat taaaagatgc acaaaaaaat cctgacaatt atcgtcaatt aatggtacgt
    51181 gttgctgggt ttactcaata ttggtgtgaa ttaggtaaac caatacaaga tgaagtaatt
    51241 gctagaacag agtatgaagg ggtgtaaaat atgagaaagc atagtgattg tatgaatttt
    51301 tgtgcagtag atgcaaccaa aggaatttgt agattatcaa aacaaatgat taatttagat
    51361 gatgcagcat gtccagagat aaaagtaatg ccaaaatgta aaaattgtaa aaattttgtt
    51421 gaagctaatg atgaaggtat aggcaaatgt gttggcctag agaaagaaga ctgggtatat
    51481 tcaacattga atgcaattac ttgtgaagga catgtgttta atgagtagtc aaaagcaatt
    51541 agaaggcatg atttttgatg tacaaagctt ttcagttcat gatggtccag gttgtagaac
    51601 aactgtattt ttaaatggat gtccactgag ttgtaaatgg tgtgcaaatc cagaaagttg
    51661 gactgtaaga ccacatatga tgtttagtga attatcttgt caatatgaaa atggatgtac
    51721 tgtatgtcat ggtaagtgta aaaatggtgc attgagcttt aatcttgata ataagccagt
    51781 tatagattgg aacatctgta aggactgtga aagttttgaa tgcgtcaact catgttatta
    51841 taatgcgttt aaattatgtg caaaacctta cactgtagat gaacttgtgc aggtaattaa
    51901 acgtgattct aacaattgga gaagtaatgg aggagtaaca tttagtggag gtgagccact
    51961 acttcagcat gaatttttac atgaagtatt attaaagtgt catgaggtaa atatacacac
    52021 tgccattgaa acgagtgcat gtgtatcaaa tgaagttttt aataaaatat ttaacgatat
    52081 tgattttgca tttattgata taaagcatat ggatagagaa aaacacaaag aacaaacagg
    52141 tgtgtataat gatttaatat tagaaaatat atcaaacctt gcaaattctg attggaatgg
    52201 aagattagta cttagagtac cagttatctc tgggtttaat gatagtgatg aaaatataag
    52261 tgatattata tcttttatgc acaaaaataa tttggtagaa attaatctat taccatttca
    52321 cagattagga gaatcaaaat ggattcaatt aggcaaggaa tatgagtatt ctgataaggg
    52381 tgatgttgat gaaggtcatc tagaagaatt acaagatata tttttggata atggtatagc
    52441 ttgttatgtt ggccatgaga cagctttcta aaattaaata caagttttaa ttaaaaaagg
    52501 atgttacact aaaagctaga gttacatcct tttttatgtg gtttttatgt agaaataatt
    52561 aagtaaagtt ttatatgttt tatatattgt ttatattgct ttatgtccat aaatattgct
    52621 ttaaatatac tttatatatt ttttatagtt taaattacag ttagagaata tattacgttt
    52681 acttcattga agcagaagtt ttgtggtaaa atactactat gaaaaaattt aatagaatat
    52741 attttagaaa caactaaaaa taatagttag gaggaagaca tctatatgaa caaatcatgg
    52801 agcaacttga ttattaagaa taaagacaga aaagtacgtt cagggtggat tattatagct
    52861 gttatggcta ccttttacat acttcagtat tatttaagca tgatacttgt ggaaataata
    52921 agaaaaatcc tggttgctac aggtgacatt aatttaaaaa caaactattt ttcagaatat
    52981 gctaattggt taaatgatgt tgggttacag attgtatttc aaattctaac agattcactt
    53041 atgattatta ttcctataat tgtatggaga tttattatga aaaatcctat tagtgaaatg
    53101 ggattacatt cttatagaat taagaaaaaa gaaggatatg taggaatgtt attaggaata
    53161 tttaattgta cagtaatctt tattataaca ataacaattg gtggtggtca tgttacttca
    53221 tgggtaccaa aaatttcacc tttaacagtt tcttggatac tggtctttat tttagttgct
    53281 tttgcagaag aaattttaaa tcgtggtttt tttatggcag ttttacgaag atgtaaaaat
    53341 atttatttta taatgattgt tccatctgtt atttttgggt tgattcatat atggaatcct
    53401 gatgttactt ttttgtctgt aattaatatt ataattattg ggattctttt ttcatatatg
    53461 tttataaaat cgtcgaatat atggatgtgt ataggttatc attttgcatg gaatgtattt
    53521 caggggatta tatatggtat gcctgtaagt ggacttcaag ttccagggat tataactaca
    53581 caaatcactc atggtaatct attaaatgga ggaatgtttg gtattgaagg tggaattttg
    53641 actacttttg ttaatctact tagctttata tttgtatggt attactatag agattctaag
    53701 tatgattttg ttagtgataa agtaaatgtg accaatatca agaattagtt gattataata
    53761 aattttaata atatcttcta agcttaaagt attctgtagg attgttggaa atttgcaaaa
    53821 atataaaaat aacttggata ttctatttac tccaagttat ttttatattc ttttgtaaat
    53881 agaaatggaa cataaaaaat taaaacaacc atagatacta ttagtatatc atggtaagtg
    53941 atagttgatt ctttagaatt tgtgataaga aaagcactat tatttaaaac atgaattata
    54001 gcacaaaacc agatattctt agtttttata taaagatatc ctaaaaatat tgaaattcca
    54061 actatatgta ttgaacgtaa tattattcct aatattggcg cttcaggtgt atataatgta
    54121 aatattagtg gtaagtgcca caagctccaa cacataccta atattataac tcctaacttt
    54181 ttaccaaatt tatcaaaaaa aatattctgt aaaaaacctc tccaggcata ttcttcacta
    54241 aaaaaaatat aaatagtagt taatgatgtt attggagtaa atataaattt tatgatacca
    54301 ctataattag gttgagcccc ttgtagtatt agtataaatg atgttggaac aattacagaa
    54361 atcataaagt aaataattaa taaagaacct agtttaatat tttttacagg atataaattt
    54421 tttttatttg atgaatatat tataattgat aagctactta taaaagttaa tattaggttt
    54481 ataattataa attcattatt atttattaga tttaataact taagaacaat taataatgaa
    54541 taaataagaa aaaataatat gattagtgaa taaaattcat acatatcatt atttaatcct
    54601 tcagtataaa actttgcaat ggcaactgaa gatagaggta atatcatcat gaatgatgca
    54661 aagttttctg gatcaataaa tttattataa tataacagta aacctaatga ataagttaaa
    54721 ccaaagttta taaagaaaaa gataataatt tgtatttttt ttctttttat ttcattttta
    54781 ataaatactg ggtttagaat atttatccat attaatttta agttc
//
LOCUS       DAEQCW010000012        52399 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.012, whole genome shotgun sequence.
ACCESSION   DAEQCW010000012 DAEQCW010000000
VERSION     DAEQCW010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 52399)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52399)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52399
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.012"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            104..487
                     /locus_tag="KRO40_000786"
     CDS             104..487
                     /locus_tag="KRO40_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091619.1"
                     /translation="MSTDKVVGIIDEETAELAGIEYTGKIYASSGVIKHIKKKHRCQL
                     SKDIFNDIIDTIKMVLKSPEYIGSHPKKPGKSVEFIKKIDDYILVATELDTKKGYLYV
                     SSMYAIKEAKLESRVNSGRVKQYDG"
     gene            993..1376
                     /locus_tag="KRO40_000787"
     CDS             993..1376
                     /locus_tag="KRO40_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH2091620.1"
                     /translation="MNLTKKIEDKRKAKQRAEKVKKAKIATAGVVLGAVTGAVSGVLL
                     APKSGKETREDIKDASQQIAEKINMKTVDVKGKVSEKLEDKKGNFIESKKKIKKYIDN
                     KKSVENSSEEDKIIDIVEPVSVTEE"
     gene            1378..1728
                     /locus_tag="KRO40_000788"
     CDS             1378..1728
                     /locus_tag="KRO40_000788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091621.1"
                     /translation="MDNTITINISIIYVLLAILACIALVYLIIVLVKLHKILNNVGTM
                     LNENTQNINTTLNNLPNVVETFGEVGENMKDVTEVVTEVTADFLVTKDSVKSNMDVIV
                     DILTIIKNIFLDKK"
     gene            complement(1829..2287)
                     /locus_tag="KRO40_000789"
     CDS             complement(1829..2287)
                     /locus_tag="KRO40_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091622.1"
                     /translation="MIRTKVVELIATVCRENKPHKWVDENYTPYDKSGKVELMSIEDL
                     NELISSSGRADFLYSSRLQKLLNEVYINQSRASYISGCGLFWSSYWDILEEKFEEWLY
                     NSYIFFDEDDEYLEGMEDFELECKDVLMDVIETTSIDIYVQMIKRNITNY"
     gene            complement(2332..3120)
                     /locus_tag="KRO40_000790"
     CDS             complement(2332..3120)
                     /locus_tag="KRO40_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2091623.1"
                     /translation="MKVVIIPGHTLIGKGTGAVGYINESKETRILNDLIVKWLKIGGA
                     TVYTGRVDESSNHLADQCAIANKQETDLAVQIHFNSNATTSTPVGTETIYKTNNGKTY
                     AERVNTRLATVFKDRGAKSDVRGLYWLNHTIAPAILIEVCFVDSKADTDYYVNNKDKV
                     AKLIAEGILNKSISNSQGGGENKVYENVIVYTGDADKVAAQILHWQLKDSLIIEASSY
                     KQGLGKKVYVVGGEANKLVKGDVVINGADRYETVKLALQEIDKL"
     gene            complement(3259..3696)
                     /locus_tag="KRO40_000791"
     CDS             complement(3259..3696)
                     /locus_tag="KRO40_000791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HBH2091624.1"
                     /translation="MNKKLENRCSWQEYFMRLCETVAERGTCDRAYVGAIIVNSENRI
                     VSTGYNGSISGDKHCSEVGHEMRDGHCIRTIHAEQNALYYCAKEGISVKNCSIYVTHF
                     PCLNCTKAIIQAGIKHIYYRTGYRIDEYAIKLLQSSNVLYTKL"
     gene            4518..5027
                     /locus_tag="KRO40_000792"
     CDS             4518..5027
                     /locus_tag="KRO40_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091625.1"
                     /translation="MLSENIKTIRKSKGLSQQELAIKLNVVRQTISKWEQGLSVPDSD
                     MLISISEVLETPVSTLLGETIVESEVDSLKVISEKLEIINLQLAQRKNMRRKMFHWLF
                     ILLCAVILIGFVVLGGLNSPYLDWNYTDPETAVFGVAFHAFEWLFVRLVPIVLIGAII
                     GIFVTRKKI"
     gene            5432..5968
                     /locus_tag="KRO40_000793"
     CDS             5432..5968
                     /locus_tag="KRO40_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HBH2091626.1"
                     /translation="MQGGVNIRQVKSFVFPVISLIFLDQISKVLIGLFLMDFEIDIIG
                     KFLRFNPVQNTNLSYGGNFIGILSNLWVLVLFNILVILVIISGYAFYKSKNEQTSYSV
                     KVIMSCGLAGTICSLIDKLFWGGSLDFLQIPSFFIFDLKDCYLTVAEIIFVVIGILHN
                     REISMKEYIYFCYRQFKK"
     gene            complement(6402..7202)
                     /locus_tag="KRO40_000794"
     CDS             complement(6402..7202)
                     /locus_tag="KRO40_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091627.1"
                     /translation="MRLNKRSEGYINYVKGVKREKRNVLFYQLLILIGFIVIWELLAD
                     LNVINTFLFSKPSDIYNLFIQYAFSGQLFKHIGISVYETVLGLVIGTVLGILVAIALW
                     WSEKLSKILDPFLVVLNALPKTALAPIIIVWVGAGIEGIVVTAVTISVVVTILSAYNY
                     FMNIDEEKIKMLKSFGATKSQILFKLILPANTGNLINLTKINIGMAWVGVIVGEFLVS
                     RYGIGYLIVYGSQVFKLDLVMMGVFVLAICAWAMYAVVNIIEKIYNSR"
     gene            complement(7397..8995)
                     /locus_tag="KRO40_000795"
     CDS             complement(7397..8995)
                     /locus_tag="KRO40_000795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH2091628.1"
                     /translation="MKAAIYSRKSRFTGKGDSIENQIQLCIDYAKSIGVKDFLIYEDE
                     GFSGSNIDRPQFKKMMQDAKDKKFSYLVCYRLDRISRNVSDFSTLIEKLNELNISFIS
                     IKEQFDTSTPMGRAMMFISSVFAQLERETIAERIKDNMYELARSGRWLGGNTPHGFNS
                     EKITFLDENLKERSMYKLQVNDEQMEIVKLIYNKYLELRSLSKLYKYVYNNGIRGPRG
                     GKFDPSSLSRILRNPAYVKANDEILDYLKNSGMDVVGTPDRKCGILTYAKNTSNSIAA
                     IAKHHGVIEPEIWLEVQNQLDKNRDKTPRISTGKTALLSGLIKCGKCGSNMRITYKGK
                     KTDKDLKYYYICGTKKTLGSDSCNCKNLNGPLVESLVIDKIKNCKEESIISAFNSNNI
                     KTDNVFNIFKSETNLLKNQILDKERLIKNLVIELAKNTGSTASDYIVSQIESLNNEIS
                     ILKDKINILESSNINISSDSINIDIIVSNLKRFNDEVDNASLDDKRLLLSTIINSIVW
                     DSSLGNLNIVYMGAEVDNSVSLSN"
     gene            9323..9499
                     /locus_tag="KRO40_000796"
     CDS             9323..9499
                     /locus_tag="KRO40_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091629.1"
                     /translation="MEINVIEIFPKDKAKLNKIEMDKASWFVNIISKKYPKEALNEAF
                     STLEKELNISKANT"
     gene            9673..10803
                     /locus_tag="KRO40_000797"
     CDS             9673..10803
                     /locus_tag="KRO40_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH2091630.1"
                     /translation="MNNFEIKTRIKFGEGSLKALQELKNKNVLIITDPFMVKSKTIDK
                     ITSNLINSTYQVFEEIVPDPPIEVVVAGIEAFKSINPDVIIALGGGSAIDAAKSIMDF
                     SKKILKINEVEFIAIPTTSGTGSEVTSFAVITDSQKKCKYPLVSDDLLPDMAILDPEL
                     VKTVPNFITADTGMDVLTHAIEAYVSTNSNDFSDALAEKAIKLVFKYLIKSYKDGNDI
                     EAREKMHNASCLAGMAFNQASLGINHSIAHVLGGKFHIPHGRTNSILLPHVIEYNSSI
                     VGYTNTTYSDTAKKYAQIAELVGLGSANIRISVRNLVNEIKKLQKEMNMPTKLTQCKL
                     SLEDITNEEREIAKLAIKDTCTLTNPKVPTEDDIINILKNIK"
     gene            11044..11394
                     /locus_tag="KRO40_000798"
     CDS             11044..11394
                     /locus_tag="KRO40_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003453843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH2091631.1"
                     /translation="MTEESKQRVIQEYVPGKQVTLAHIIANPNEDIYKKLGLVLDKKD
                     AIGILTITPSEASIIAADVATKASNVSLGFIDRFSGSVVISGDVSSVESALNDVLEVL
                     GNMLNFSSTKITRT"
     gene            11402..11851
                     /locus_tag="KRO40_000799"
     CDS             11402..11851
                     /locus_tag="KRO40_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutP/PduV family microcompartment system
                     protein"
                     /protein_id="HBH2091632.1"
                     /translation="MKNIIFMGKTGSGKTTLCQKLDQLELKYKKTQSVELYNNAIDTP
                     GEYMENRNLYNALITTSADAKIIAIVYDATQEENYIAPGFASMFCKDVIGIITKINKA
                     TENEVNIAYERLSLAGASQIFKIDTVDNIGLEKLFKYLEKYKNIDEV"
     gene            11953..12528
                     /locus_tag="KRO40_000800"
     CDS             11953..12528
                     /locus_tag="KRO40_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH2091633.1"
                     /translation="MGKKILLVDDEPLLRMDTKDILESHGYEIIGEASDGFEAVEMCK
                     KHKPDLVIMDIEMPILDGIKAGKIICKENLAGGVLLLTSFEDKEYVEKAKSIGAYGYL
                     VKTASEKSLIPTIEMCLNKVNEFEKMKKDLEKVNSKLNERKLVERAKGILIREFKISE
                     DEAYTRIRKLSMDKRTTMMEIAKMIIIGYDD"
     gene            12521..13930
                     /locus_tag="KRO40_000801"
     CDS             12521..13930
                     /locus_tag="KRO40_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase N-terminal domain-containing
                     protein"
                     /protein_id="HBH2091634.1"
                     /translation="MTNTIKKISTAQTYLNNNEIEKIIEVSKSLDLMASFYEADVFID
                     VLSKFDDEAIVVAHGRPKEKSMYCENVIGKKALIENEPGVIKCLKTGERVRDIKALTQ
                     EYKLVKQNIQPITLDDKVLAVLIVEKDISSEVKNEFNASEDEENKNLHQFIKLIGNND
                     FLVDNLNSAILIFDKNGKLKIKNRIATEIYKNLGFGYDIQDMHYNDLDIETNTFENIL
                     MDENYDETNEVSIGNMFFKIKTIYIKDDEFKVCKIVQDISDLKRKEEELVLKTVAIRE
                     AHHRVKNNLHTVISIIKKQSRLSQNDEVKQCLDNIINRVFAILSTHYLLSKEVDNNIS
                     IREGINLLVSNIQGGYLFSKDIDIRITGEDFKISGEKATAILLVINEILQNCYDHAFS
                     DREHGTIQILINKDNDYRNIAIIDDGIGFDSNNINKNSLGTYIIDSYITQMLKGNIER
                     KSSENGTEVLITIPTQINI"
     gene            14114..15547
                     /gene="eutA"
                     /locus_tag="KRO40_000802"
     CDS             14114..15547
                     /gene="eutA"
                     /locus_tag="KRO40_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004458698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase reactivating factor
                     EutA"
                     /protein_id="HBH2091635.1"
                     /translation="MREELLSVGIDIGTSTTQLIFSKLIVENTESNFSVPRISIVDKE
                     IIYKSKVYFTPLISNNEINGQQIKDIVENEYKKANISKEDIHTGAVIITGETARKENA
                     NDVLHTLSGFAGDFVVATAGPDLESIISGKGAGAHIYSKEHSTTIVNIDIGGGTSNIA
                     SFKRGEVTDTGCLDIGGRLVKIDKISKKITYISPKIDKIIKDNNLNLQVGTMATVENT
                     KPIVDIMVDLLMESIGLKKQTPLFDFIITNKSISIDETIKNVSFSGGVADYIYYDGEI
                     KDYFEYGDLGILLGQAIKNCEYLKKVNVVKSMETIRATVVGAGSHTTEVSGSTITYTS
                     EKFPLKNLPVLKLSIDEETGTSKQISEAIKNKLNWFKLENDLQKVAIAMIGKKNPTFL
                     DIQEYAKGFVDGMQQIIENDLPFIVIVENDMAKVLGQAIYALLNYEKEIVCIDSVKVE
                     NGDYIDIGKPIVEGKVLPVVIKTLVFN"
     gene            15565..16929
                     /locus_tag="KRO40_000803"
     CDS             15565..16929
                     /locus_tag="KRO40_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutB"
                     /protein_id="HBH2091636.1"
                     /translation="MILNTKLFGRTYQFKGLYDVMAKANEEKSGDKLAGLAAESAEER
                     IAAKVVLSHIKLEDIRNNPAVAYEEDEVTRIIQDAVNEKVYEEIKNWTVSELREWLLD
                     SNTTSLDIRRISRGLTSEMIAAVAKLMSNMDLVYAAKKIKVTAHCNTTIGEQGTLSAR
                     LQPNHPTDDPDGILASLLEGLTFGIGDAVLGLNPVDDSVESVTKVLKRFEEVKQKYQI
                     PTQTCVLAHVTTQMEAIRNGAPADLIFQSIAGSEKGNEAFGFNGDTIEEARQLALKHG
                     TATGPNVMYFETGQGSELSSEAHHGIDQVTMEARCYGFAKKYEPFLVNTVVGFIGPEY
                     LYDAREVVRAGLEDHFMGKLHGLPMGVDVCYTNHMKADQNDMENLAILLTTAGCTYFM
                     GIPHGDDVMLNYQTTGYHETASLREMFGLTAIKEFDAWMEKMGFSKDGKLTELAGDAS
                     VLLG"
     gene            16942..17823
                     /gene="eutC"
                     /locus_tag="KRO40_000804"
     CDS             16942..17823
                     /gene="eutC"
                     /locus_tag="KRO40_000804"
                     /EC_number="4.3.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014952556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutC"
                     /protein_id="HBH2091637.1"
                     /translation="MNEKDLKALVEQLVGQMVGELDTNVVSETVKKATEVVVDNNAYI
                     DDITEVDIRKQLLVKNPKDAEAYLDMKAKTPARLGIGRAGTRYKTETVLRFRADHAAA
                     QDAVFSYVDEEFIKGNNMFAVETLCKDKDEYLTRPDLGRKFSPETINNIKSKFGTNQK
                     VLILVGDGLSSAAIEANLKDCVPAIKQGLKMYGIDSSEILFVKHCRVGAMDHLGEELG
                     CEVICMLVGERPGLVTAESMSAYIAYKPYIGMAEAKRTVISNIHKGGTTAVEAGAHIA
                     ELIKTMLDKKASGIDLK"
     gene            17843..18496
                     /gene="eutL"
                     /locus_tag="KRO40_000805"
     CDS             17843..18496
                     /gene="eutL"
                     /locus_tag="KRO40_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003761789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization microcompartment
                     protein EutL"
                     /protein_id="HBH2091638.1"
                     /translation="MKNDVIRPNILGIKIISNISPEMAQKLELKSHHKSLGLITADCD
                     DVTYTALDEATKASEVDVVYAKSMYAGAANASTKLAGEVLGIIAGPSPAEVRSGLNAV
                     VDFLEYGATFISANDDDSIAYYAHCVSRTGTYLSEVAGIREGEALAYLVAPPLEAMYA
                     LDAAMKAADVKMCELFAPPTETNFGGALLTGSQSACKAACDAFAEAVKSVADNPTGF"
     gene            18507..19208
                     /locus_tag="KRO40_000806"
     CDS             18507..19208
                     /locus_tag="KRO40_000806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH2091639.1"
                     /translation="MDAIGLIEVIGYVAAIEASDACLKSANVNIVRVDKVGAGIVTLT
                     ICGDVGAVKAALEAGEIAASRVGTLRTSHIIPRIHNEVTNALFKTKEPKVCEVSEDKE
                     KNFEITLEITDNVSKNLSEKENVILDVNENSGNTENLYSDIDKTNKKIETVDDSLTEA
                     NEEKIENTNDKEVLEQVKIENSDFDRDDLSKNSVKKLKAMAKKLDSSITYKDLNVLKK
                     EELINLVKKLSRRDR"
     gene            19211..20680
                     /locus_tag="KRO40_000807"
     CDS             19211..20680
                     /locus_tag="KRO40_000807"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="HBH2091640.1"
                     /translation="MTLLDKDLVSIQEVRTLVRRSKVAQEKLSKMSQEQIDKIVKSVV
                     DAAFNNATKLAKMANEETGFGKWEDKVIKNTFASMGVYETLKNTKTIGIIGEDKEANT
                     IDIATPVGVVAGLIPSTNPTSTVIYKTIISLKAGNTIVFSPHPNAKNCILETVNIISE
                     AAIKAGAPEDSILCITNPSIVGTNELMKHKDTNLILATGGEAMVRAAYSSGTPAIGVG
                     PGNGPAFIDKSANVKLAIKRIIDSKTFDNGVICASEQSIVIEKSMEETVLKELKNQGA
                     YVLNEEESERLAKFILRANGTMNPQIVGKSVEVIANLADLTNVPKNTKVLVARENKVG
                     HNVAYSREKLTPILAFYVEENVEAIMNRCREILLNEGAGHTFSMHVNDEELVKRFALN
                     MPVSRILVNTPSALGGIGASTNLVPALTLGCGAIGGSSTSNNIGPLDLINVKRVAYGI
                     KEIEELGRDKSQVEKSMFDSMDKEELINLLVQKLVKELA"
     gene            20776..21063
                     /gene="eutM"
                     /locus_tag="KRO40_000808"
     CDS             20776..21063
                     /gene="eutM"
                     /locus_tag="KRO40_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization microcompartment
                     protein EutM"
                     /protein_id="HBH2091641.1"
                     /translation="MASANALGMIETKGLVGAIEAADAMVKAANVQLVGKEQVGGGLV
                     TVMVRGDVGAVKAATDAGAAAAERVGELISVHVIPRPHFEVDAILPKVSAE"
     gene            21190..21951
                     /locus_tag="KRO40_000809"
     CDS             21190..21951
                     /locus_tag="KRO40_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP--cob(I)alamin adenosyltransferase"
                     /protein_id="HBH2091642.1"
                     /translation="MGVLTESEVKRKIGKNKNNITEFYIEKGQIITPSAKSYLAERSI
                     ELKYVDKLSDVNNEPKEVVKEVVKEKKYRYTTVFGAKLDEKPEHMTQLNGNLLVFKDH
                     KRIILRGKIDSLESEILKVQILCQKLDMPKLVKELQEVLDFVRNIMRCEVLDEKLGDF
                     KLLGLTPQELREQSHYPKKYFGIGHEFPSYEMGEVVVAINSIRSNTREVELAAYEAFK
                     GEYGNVHREDLIKALNRLSSVFWIMIYKVRTNKYK"
     gene            21964..22593
                     /locus_tag="KRO40_000810"
     CDS             21964..22593
                     /locus_tag="KRO40_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBH2091643.1"
                     /translation="MENLLNEIVEEVITRVKKEAFIEVEASGRHVHLSREDVDKLFGE
                     GYTLTKLKDLSQPGQYACKERVTITGPKGSIKNVVVLGPCRNETQVEISLTDGSTLGL
                     KAPIKQSGDLEGTLSIKISTQYGEVELDKGLMVAKRHIHMTPKDAEKFNVCDKEIVEA
                     KVMGQRPLTFDDVVIRVSDSFKTYMHIDYDEANACGYSKGTVAKIIKKA"
     gene            22635..23360
                     /locus_tag="KRO40_000811"
     CDS             22635..23360
                     /locus_tag="KRO40_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02536 family ethanolamine utilization
                     protein"
                     /protein_id="HBH2091644.1"
                     /translation="MNYDNLVDLITEEIYKKINSNEIKISNKPKAVIVFEQDNNKFNL
                     LKDEFEIVEFDKSIRECEIVIVSRLCMRGLSNIALGNSTSDEERFILKMIMKGKEVYV
                     LDEGIEYKKYKDTAPKALYKKFMSFEDEICKFGVEIIKDLNVITKNKLNIKKELESTR
                     GSKKEDTKVLDKDVLNLISVESVKIDNEFSLDLRNKKLISEADLRKPTINGVKNILVN
                     KKSIITPLAVDFMRIHHLKLKKV"
     gene            23373..23645
                     /locus_tag="KRO40_000812"
     CDS             23373..23645
                     /locus_tag="KRO40_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutN/CcmL family microcompartment protein"
                     /protein_id="HBH2091645.1"
                     /translation="MDIGKVVGNVWATRKDEKLCGQKLLVVKILKTKDTYKEGFMVAA
                     DNAGAGNGDLVLISKGSSARESIEKSHVPVDATIVGVVDSFEVFDE"
     gene            23638..24189
                     /locus_tag="KRO40_000813"
     CDS             23638..24189
                     /locus_tag="KRO40_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBH2091646.1"
                     /translation="MNKSIGAIEFKSIAKGIEVSNEMIKKSSVDVLYLKSICPGKFLI
                     IVGGETSYINECVDYGIKLGEGYIVDNFVINAISQEILDGFKNKYQKLDSIVSIGVVE
                     SSKVCAGIKMLDKTLKSGDLVLVKLQLSFAIGGKLVYIVAGDLSSLEYALKESENVVR
                     EKEVIYKTVIPSVDSQIIKSLIK"
     gene            24201..25292
                     /gene="eutH"
                     /locus_tag="KRO40_000814"
     CDS             24201..25292
                     /gene="eutH"
                     /locus_tag="KRO40_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBH2091647.1"
                     /translation="MSINEIIIYVMVVFMVLGAIDKCIGNKFGLGEQFEEGIMAMGSL
                     AVAMVGVICLAPVLADVLRPIVVPVFNILGADPAMFAGSLLANDMGGAPLALELAKDP
                     NAGLFGGLIVGAMMGPTIVFIIPVALGIIEKEDQKFLATGILAGIITIPIGAFVGGLV
                     AGFEVMMVLRNLVPIIIFAVVIALGLLKFENAMIKGFTYFGKGVVIVITLGLAAAIVE
                     ALTGIVVIPGMKPISEGIEIVGDIAIVLAGAFPLVFVITKVFNKPLMALGKVLGMNDV
                     SAAGLVASLANCIPMFGMMKDMDNRGKIINVAFSVSAAFVFGDHLGFTAGFNSNMITP
                     MIVAKLVGGITAVLLAMVIANKTLKKENV"
     gene            25294..25767
                     /locus_tag="KRO40_000815"
     CDS             25294..25767
                     /locus_tag="KRO40_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF861 domain-containing protein"
                     /protein_id="HBH2091648.1"
                     /translation="MDISNIDKNLIETLVRQIIEEKISGTKDTVDFVRNKDISGITSI
                     KLPTVKVSESDRLDTGNPSDVVYTKDLFTLEESPRLGCGMMEMKETTFDWTLNYDEID
                     YVIDGTLDIIIDGRKVSASSGELIFIPKGSKIQFSVPDYARFIYVTYPADWASQN"
     gene            complement(25887..25988)
                     /locus_tag="KRO40_000816"
                     /pseudo
     CDS             complement(25887..25988)
                     /locus_tag="KRO40_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433047.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
     gene            26283..26804
                     /locus_tag="KRO40_000817"
     CDS             26283..26804
                     /locus_tag="KRO40_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2091649.1"
                     /translation="MEEIVKKEQASMNDIFLYLKAKSNSLYKFVILYNEFINKPKDYG
                     TGELINMVEVHMLTAIEENPGISPTQLAKIWNRTKGAISQTISKLEKKGYITKEKKEG
                     NAKTILLYPTTSGVELSKAHKLYDTIDVTRTFEYLIKECTLEEIDSFYKVIDLFINLL
                     EESPQENNDSEKV"
     gene            27183..28358
                     /locus_tag="KRO40_000818"
     CDS             27183..28358
                     /locus_tag="KRO40_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2091650.1"
                     /translation="MNLKQLSEKYEEYVIQMRREFHKYPELSFKEIRTTQRIREELQK
                     IGVPFVSIEPNIVIATIQGKNEGKTIAIRGDIDALPMQEDSDVEYKSEYDGIMHSCGH
                     DAHGAMLLGLAHMLNDIRKDLKGRVLLVFQAAEEVGGGHKEIIQYFKENGGPDRLIAT
                     HVWSDIEAGKISVEPGPRMAGGSGWRIDITGRGGHGSRPDQSIDPIKPACDIVLKVSS
                     IPVNHISVLEQCVVHACAIHGGTTIGNVIPNNAEVIGGYRYFTEESGKKVFDIIKQMS
                     NGVGQVYGVDVKVTHTGGIGPVINDEEAVKMAKEIVSNIDGLELDSYEPICASDCYGE
                     ILKEYSGFYCYLGVGNKEKGIIYAQHHPKYNIDEDTLKLGCEFMAKYAVEFLNKNNN"
     gene            28393..29931
                     /locus_tag="KRO40_000819"
     CDS             28393..29931
                     /locus_tag="KRO40_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH2091651.1"
                     /translation="MQGALKENKKKSGGGFLGWIEKVGNKMPHPLALFTYITLIVVAL
                     SAIASFLGFSATSPATGKLIKVMNLISAKGLVLFMQEFVKNFQNFPVLGVVLVMAVAT
                     GVCEKTGFFSTAIKMSLSKVKGNAVVFIIAFIGVFANQAGDAAFVLVPTLAGAIFYGL
                     NRNPLAGIFCGFASVGGGFATAVIPGGWDVTLTPITVSAAQTIQPAFDMTLLASYYAL
                     FVSAFIVATVSTIVTVKFIEPKLGKYTGKPEGIDDNQGFEVTKEQAKAAKLAGFTVLA
                     YVALLIALCIPANSFLRSPEGSLIFGAPLMSCLQFFIVILFFLPGIVYGMRVGKIKTV
                     KDLNDILCQSMAAMAPFIVLAIVIGQFLTLFSVSNLAQVLAIKGGALLNSLPLPPQAI
                     ILLFLVLVAFINIFVISGSTKWMIFGPVFVPMLMQLNIHPAFTQFVYRLGDSVTNHLS
                     PLNAFFIILLATVQKYDKNAGMGTIFSAMIPYTIGYFVVLAVLVVVWMTIGIPVGIGG
                     QVWL"
     gene            29963..31165
                     /locus_tag="KRO40_000820"
     CDS             29963..31165
                     /locus_tag="KRO40_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2091652.1"
                     /translation="METTEIRYNFDEVIDRSGTNCLKYDLKSQFMPESPEDALPLWVA
                     DMDFACAPEIINAMHERIDRKIFGYSSQQTDDYYEAVCGWFKRRFDWKIEKENIFFSP
                     GVVPALGFFTQILTQKGDGIIIEKPVYYPFEDKITNNERKVVNSPLKFEDGHYSMDYD
                     GFEELAKDENNKVFILCSPHNPVGRVWKKEELRKIVDICKKYDLWIISDEIHCDIIRK
                     GEKHIPLEVACPDYKDRIITCTAPSKSFNLAGMQLSNIVINNKELQKKWMLETDSKLA
                     IFLPNPFAIVATKVAYNDCEDWMNQVNEYIDGNIKYVEDFVNEYMPKVKIIKSQGTYL
                     VWLDFRGYGLDAKQLEYVMLNKAKVLLDEGYIFGEEGAGFERINVASPRTIIEECMNR
                     IKCAFEGL"
     gene            complement(31332..31931)
                     /locus_tag="KRO40_000821"
     CDS             complement(31332..31931)
                     /locus_tag="KRO40_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2091653.1"
                     /translation="MNDNIVEVKNINMNFYTKEGELEVLKDVNFNLKEGEILTLLGPS
                     GSGKSTILNILTNLLKPTSGDIKITGNIGYMFQKDNLLEWRNIMDNITIGLEIQGKKD
                     KKSLDRVESLLKTYGLWDFRSMYPKELSGGMRQRVALIRTLSVNPDILLLDEPFSALD
                     YQTRLLVCDDVYSIIKNENKSTILVTHDIGEARCIKVQL"
     gene            32101..33459
                     /locus_tag="KRO40_000822"
     CDS             32101..33459
                     /locus_tag="KRO40_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091654.1"
                     /translation="MSNIITNLIESIFTNPITILFLLAITVYSVFKIIENNRVYSFVS
                     SKLDEINRDYKTSEFYKKVRDDYYTYSKENPYADVNITSFIEEVVSDLKHNNLPLLEK
                     IRSIKNSSSISILLGVLGTFVGLSTMLLCVDTKDIINSLPSTISSMQTAFTTSIFGVV
                     FSLIIGYFTKIKDCEHVLIQIMLKSENLLTSEITHFKSERMDLKVEEVKNTIKQISKS
                     IEAIEKFDKISKDLNDFNDEFISGIEALKSLLEGSQSSIKTFDQSVRKLDKQFNILNI
                     KFVKLFDKYDNQDNINKEILFDIKESSKNIYNATESQFKIRDYIKNINAGFALYERSA
                     QDLLTKLMTHENKISQNQKILLDEKFTLDDSIKNLSSIIENFSNDLQVKLDMMFENSL
                     DIQDKLDVMFNNSFMNDEVPLDSEELFKDDVNNVFNPFSEEIYEIEDKEIKVIGEDEL
                     NE"
     gene            33452..34084
                     /locus_tag="KRO40_000823"
     CDS             33452..34084
                     /locus_tag="KRO40_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH2091655.1"
                     /translation="MNNKYRRTVNREFEKSSFWPTFTDLLSTVLMVVILILFSSESIS
                     GSVEQDLAKNVNASVEETFKKSGIPVKVDKSNGQVTFGEKTMFDVDSDVLKPEAKEML
                     KMFVPKYIETIYKDYGDYISKIVIEGHTDDVGSYIYNLDLSQRRAYSVAKFIVGDEIG
                     DYKYKDKVTKHIIAIGRSKAELIKNGDNSVNRDASRRVELKYEININQNK"
     gene            34413..35570
                     /locus_tag="KRO40_000824"
     CDS             34413..35570
                     /locus_tag="KRO40_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2091656.1"
                     /translation="MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNN
                     NDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFTLIDGGDNDDEGLMVDYLNNQGV
                     KDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
                     VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILP
                     KLEKVDLLKVAHHGSRSSSSQEFLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGV
                     KVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNSNTSKNDSFKNKQNT
                     SNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK"
     gene            complement(35717..36352)
                     /gene="lexA"
                     /locus_tag="KRO40_000825"
     CDS             complement(35717..36352)
                     /gene="lexA"
                     /locus_tag="KRO40_000825"
                     /EC_number="3.4.21.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor LexA"
                     /protein_id="HBH2091657.1"
                     /translation="MYLDLTEKQVLILEFIKSQIILKGYPPAVREICTAVGLRSTSTV
                     HSHLNKLEKLGYIRKDPTKPRAIEVLERSKVNDVSGANQEIIELPLVGQITAGEPILA
                     QQNIEEYIPFPASLVKGSNNFVLRVKGESMINAGILDEDYVVVDKKNTALNSQIVVAL
                     INGESATVKRFFKEGNLIRLQPENDFMEPIMLNDSEVEIVGIVTGVFRVIK"
     gene            complement(36456..37583)
                     /locus_tag="KRO40_000826"
     CDS             complement(36456..37583)
                     /locus_tag="KRO40_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH2091658.1"
                     /translation="MNNDKKIIKVHNKSDKPDNIVIKENELIEKCLLLENKLPVFMKD
                     YFIYLKGSVAVSTRLAYLEDINFFCSYLIETKELTNADCVKDITEDDFNTIKSRDINL
                     FLGDYCSRYYKNTEKNTLIFENNNRALARKKSSISTLFKFLYRNSQIDNNITDGFNPI
                     KLPKPQPDAIKRLEIDEVAKMLESVETGEGLTEKEKVYWRKTKLRDKAILALFVTYGL
                     RLNELRELNISSFNFSRGEFKIYRKRGKEVLMPINHTCEHVIKDYLQNERTRDELLND
                     EEKDALFLSLQNKRITAKAIRTLVKKYTSIPLDTTRDNGYSPHKLRATAATSLIQTGF
                     SIYDVQNLLDHDNVTTTQLYAAHKKNVKRDIVKNFEWIEDD"
     gene            complement(37867..38712)
                     /locus_tag="KRO40_000827"
     CDS             complement(37867..38712)
                     /locus_tag="KRO40_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091659.1"
                     /translation="MIYIIEILKISVINIFCFIGIFIVFGLIFSITENLNNKFIFSSF
                     GKTGIIVTGAIGTFVHELSHLIMCLIFMHKINSVKFFRPIESKNDGILGYVSHSYKKD
                     NLYQSIGNFFIGIAPIIGGTIMIILIFKILLPDSYMKVTQNIDLKLYVSMINNLNING
                     FIHIILGDISNFIRIMLLTPSVYSLKYFIFMFLMYSISTHMSLSSADLKNSLNGLSFI
                     VIVIFVISSITYLFGFDNLNISSLIVKYNIFISFFMAIGFIFSIVTLIISYILSLVSP
                     FKNFS"
     gene            complement(38742..39113)
                     /locus_tag="KRO40_000828"
     CDS             complement(38742..39113)
                     /locus_tag="KRO40_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH2091660.1"
                     /translation="MKLKLLVEEYAVCRLNNDSKIPTWIDTEKFYSITRTDDELSVVC
                     LNNNIPSDVKSEKEWRILKILGPLDFSLVGILSKLSSLLADNKISIFAISTYDTDYIL
                     VKEKDIENACKILSCNGYEVE"
     gene            complement(39266..39526)
                     /locus_tag="KRO40_000829"
     CDS             complement(39266..39526)
                     /locus_tag="KRO40_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003866776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein S"
                     /protein_id="HBH2091661.1"
                     /translation="MEVLKVSSKSNPNSVAGALAGVLRERGVAEIQAIGAGALNQAIK
                     SIAIARGFVAPSGMDLVCIPAFTDIEIEGDKKTAIKLIIEPR"
     gene            complement(39715..40659)
                     /locus_tag="KRO40_000830"
     CDS             complement(39715..40659)
                     /locus_tag="KRO40_000830"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit alpha"
                     /protein_id="HBH2091662.1"
                     /translation="MIENNSEKIKILENDIKQLITISKANNIDLSDKINSLNEKLEKL
                     KEDAFSHLSAYEKVTLSRDIKRPTTLEYIEHICSNFLELHGDRLFKDDPSMVGGIGQI
                     GKFNVTIVGHQKGRDTKENIKRNFGMPHPEGYRKALRLMKQAEKFNRPIITFIDTSGA
                     FCGLEAEERGQGEAIARNLLEMSKLSVPVITFVIGEGGSGGALGIGVGNDVCMLEHSV
                     YSVISPEGLSSILFKDSSKAKEACDVMKLTSNDLYDLKIIDKIIKEPLGGAQKDVEAV
                     SKEIKAYILERLNHYKDMDKEEIIAQRYKKFRNIGKCL"
     gene            complement(40680..41534)
                     /locus_tag="KRO40_000831"
     CDS             complement(40680..41534)
                     /locus_tag="KRO40_000831"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HBH2091663.1"
                     /translation="MIKKFLSSKESKYVTISLDDNFKKNSVDDKFWTYCKGCDSHVFR
                     KDIEENSFVCPKCSRHYGLRARKRINLLIDKGTFMEFNSDVEFQNPLNFPKYKEKVDS
                     YKEKTKESEAVVTGYGRINGIKTVICVMNPDFMMGSMGSIVGEKITYSIEYAAENNLP
                     IIICSASGGARMQEGMVSLMQMAKTSQALSKLEEKSLPYISVLTDPTTGGVTASFAML
                     GDIIISEPNTLIGFAGPRVIEQTINQKLPEGFQTSEFLLEKGFIDMIVDRRKMKEVLY
                     QILAMHKK"
     gene            complement(41549..42910)
                     /gene="accC"
                     /locus_tag="KRO40_000832"
     CDS             complement(41549..42910)
                     /gene="accC"
                     /locus_tag="KRO40_000832"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HBH2091664.1"
                     /translation="MIKKILVANRGDIAVRIIRTCKELGIKTVAIYSEIDKDCFHRYI
                     ADESICIGPNNISKSYNNIENIIYLALKLKCDAIHPGFGFLSENPEFAKQCEDNNIIF
                     IGPTREQMILMGDKSRARETMMELNIPVVPGSESVLKTKEEALEVAREIGYPVMIKAS
                     SGGGGKGMRIVRKEEELFSNFDMASSEALAAFSNSDLYMEKFIENPRHIEVQVFGDKH
                     SNAIHLGDRDCSMQRRNQKVIEESLSPYLSDEERQKLHKIAVDIVKGVGYIGAGTIEF
                     IVDKDKNFYFIEMNTRIQVEHPVTEMVTNLDLIKLQISIANGDKIPFKQEDITFRGHA
                     IECRINAEDSSKNFAPSPGKIESLNLPGGFGVRFDTFVYAGYTIPPLYDSMIGKLICW
                     AETREECISRIYRALDEIIVEGINTNVEFQKALVTSEEFREDTHHTKFIEDVFMKKEF
                     ATL"
     gene            complement(42926..43378)
                     /gene="accB"
                     /locus_tag="KRO40_000833"
     CDS             complement(42926..43378)
                     /gene="accB"
                     /locus_tag="KRO40_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HBH2091665.1"
                     /translation="MNINEIKELLKAIDSTNLEYVKLESSDLRLEVSKKAQSTSSPVL
                     SVQQESVVDLSLEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPSPDADSFVKVGDVVE
                     EGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKPL"
     gene            complement(43648..44094)
                     /locus_tag="KRO40_000834"
     CDS             complement(43648..44094)
                     /locus_tag="KRO40_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091666.1"
                     /translation="MESKFFNWYTQSLGGTFGIISCICAYLNGYMFVYTNSASKYFES
                     IGFLGIISSYTLLPLCMLTLIFGVIYSYTPETSDKSIFNIPFFTLNKRLILITVVFGF
                     IGARVYFIIPAILITFNLYSNVLIAKLKYILCKNKENDTNLKESEV"
     gene            44369..44647
                     /locus_tag="KRO40_000835"
     CDS             44369..44647
                     /locus_tag="KRO40_000835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424072.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091667.1"
                     /translation="MVDTLEFGLKILFFILSIIWMGKIMILRTDKQIVINPLLIGISA
                     VLVMLHTSQSNIEFFGLDVQYIRIVLYIIYSLIILIGIWATNRRNGIF"
     gene            complement(44776..45522)
                     /locus_tag="KRO40_000836"
     CDS             complement(44776..45522)
                     /locus_tag="KRO40_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091668.1"
                     /translation="MWEGTMNLANLIPFIISAAALSPINSNDKVLSENQLKDIFPDAN
                     LRAVVKRYINPDEMTISNIKALDGEFYATGESISNLKGISYLENVDNFIFWNNNIKEV
                     PKEALSLKDMDSINLANNYLIDDDVVNSLSHNGVDVNCDLNFIDTKDNQYKLDSKYHN
                     VDIAKGESIDLRKIITKKIDSYYKYWEVTDNLPKDLNFIVSVSDKSVLSCEDMIIKGN
                     KTGQAVVKVILSDKNDLNTSQEVLITVNVK"
     gene            complement(45651..46295)
                     /gene="trmB"
                     /locus_tag="KRO40_000837"
     CDS             complement(45651..46295)
                     /gene="trmB"
                     /locus_tag="KRO40_000837"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HBH2091669.1"
                     /translation="MRRRRKKGADEKLLSYTKYVLRDDIDKLKGKWNLKFRNDNPIHV
                     EFGTGKGKFITTLAKQNPDINYIAMELKEEVLLKAVEKADASNLNNILFLWGDVSNIL
                     DYFEAKELSRIYINFCDPWPKNRWSKRRLTHSGFLEMYNRVLEDDGEIHFKTDNEKLF
                     EFSLNEIAANNWLLKNISLDLGNSEYENNVTTEYEDKFMSQGMRIFRCEAKKRN"
     gene            complement(46433..46753)
                     /locus_tag="KRO40_000838"
     CDS             complement(46433..46753)
                     /locus_tag="KRO40_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein HesB"
                     /protein_id="HBH2091670.1"
                     /translation="MKITLPETAIDTLKSILKDNQDKPNNIRVYFAGVGCGGPSFGLA
                     LDEKKEDDLTYEVGELQFVMSSDEYSQYGDIIIEDTGFGFRVIPENMKDQGGGGCSGC
                     SGCH"
     gene            complement(47206..47454)
                     /locus_tag="KRO40_000839"
     CDS             complement(47206..47454)
                     /locus_tag="KRO40_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2091671.1"
                     /translation="MQKTKAWGIIEPEKPESQQQMAHMDFAVNDLEEAVQYAIHCGAT
                     IAEEQFTDDWRVMIDPAGHPFCLCQMKSIMESSHFSLL"
     gene            complement(47485..47946)
                     /locus_tag="KRO40_000840"
     CDS             complement(47485..47946)
                     /locus_tag="KRO40_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBH2091672.1"
                     /translation="MKFGGVLLIVKDINKSKKFYEDVMEQKITLDLGEHVSFENGFGL
                     QSNYKAIIGYDLPIYQQSNNFQLYFEVNDIKQWESKINRIGNIEFLHYIKEYPWGQRT
                     FRFYDFDKNIIEISESMESVIKRFLKQGLALEEISKRTMYPVEFITQFQQL"
     gene            complement(47984..48817)
                     /locus_tag="KRO40_000841"
     CDS             complement(47984..48817)
                     /locus_tag="KRO40_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091673.1"
                     /translation="MLKKESIHFINKNRSLIVCEDNFVYLLPCIQLRNWISNFTISFP
                     NQTIISDNYTIIPHGSVTLVFFYDATGLHSLLFGPTTKPKTVGNIANRCDVILIIEFQ
                     PAGFFPLIGIQQSELIDKVVPFSIINTSLDLEIKKIFNESLSIDKLILKLEELLISNI
                     KIEYSYEFILAIQLIIQNSGNISSQEISKKVFYSSRHLNRLFNQYLGLSMKSFSRLVR
                     INKSIKLLNNNKTSLMSICNELGFYDIPHFIKDFKIVCGITPQKYRANMSDFYSEIAK
                     F"
     gene            complement(49091..49777)
                     /locus_tag="KRO40_000842"
     CDS             complement(49091..49777)
                     /locus_tag="KRO40_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091674.1"
                     /translation="MKITHNSLAVEAKNIIKEYKIGNTTTRVLKDVSLQVMKGEFVSI
                     MGQSGSGKSTLLYILGGLDTPTSGKVYMNGADISHFNDEKMSIIRRRNIGFVFQFYNL
                     IPNLNVEENIMLPLLLDGKNLKDYKNQLDEILDIVGLTDRRKHTPRELSGGQQQRVAI
                     ARALIGKPEILFADEPTGNLDSKTGIEIIDLLNKINRDNGQTIIMVTHSPEAAKSSSR
                     TIIVSDGLIV"
     gene            complement(49792..52269)
                     /locus_tag="KRO40_000843"
     CDS             complement(49792..52269)
                     /locus_tag="KRO40_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2091675.1"
                     /translation="MKIILKYIFTNIKERKIRTAVMLLSIVLSTVLLFVSFSIGLSYE
                     SAQRKMAKGMYGTATISVQSKNPDILTNLEDIPDLNTIKSKVGVLESSAIYNKGGYYE
                     EFSLISADLSQLNKINKPRLENGDSITDFSGDKIILPNRFTSKYKIKKGDSITLQIYG
                     KSYTFQVSDIASYDTVFLRNTRGVNALLPKETLSKIINKGSGYTRVLIESEEEITENL
                     VNKLSEELSTEKYMVSNTINETKIISDARQKTMPFFLISFFALTLSIFIIYSSYKVIT
                     LERLPFIGTFRSIGANEKTVTRILMLESILYGSIGGLIAIPIGVVVLNLMLHGLGNSL
                     EQGISIPVVISPIGVIISVIVAIIVSSFSAYIPVKKASHLPIKNIVLGTVEEKNVSNR
                     SILFIGSIMFILSILLPRISPENTLYLAGGFSLLGLIVATIVLIPLITDIMSIVFEFV
                     YKNILGNEGKLAARNMKNNKNIIQNITLLFISISAVIAISVVGNFVKTYITDVFRDAE
                     LQGFADGKMNEEFIEDVRHMDGIKKILPLYVMNNEISGNGVTLSRLEGTDNIKLYNSM
                     FGINYTNFEIKKQVIEAFNDKRSVILNEDTLKKVGLSIGDTITLSNDKYDFSYKIVGS
                     FKSRANDVEAVIPSHYAVNDFDKTNYGFLVYTAVNPDAVMIQIRYLFGDTYNWSRTVE
                     EFNNDSLNTISSFLSPMNKMTYFIFLLATVGIINNLLINYIQKRRSIAMYKSIGLSDK
                     QNIKVTLIEGFTSGLLGAVIGIVISILEIQTIFIVAGPKISMKPDLDFKTFIIVGLLG
                     IIVTLIGSIVPIIKGKKMKLIEEIKFE"
BASE COUNT        19691 a         7078 c         7756 g        17874 t
ORIGIN      
        1 atcttttctt tttggaataa actatacttt aaatatagat atttaattta aataaatttt
       61 acagtattaa tagtaaatta tcttagaaag gaatgtgctt tatatgtcta cagacaaagt
      121 tgttggaatc atagatgaag aaacggcaga acttgcagga attgaatata ctggtaaaat
      181 ttatgcttct tctggtgtta taaaacatat aaagaaaaaa catagatgtc aactgagtaa
      241 ggatattttt aatgatataa tagatactat aaaaatggta ttaaagtcac ctgaatatat
      301 aggaagtcat cctaaaaaac ctggaaaaag tgtggagttt ataaaaaaaa ttgatgatta
      361 tattttagta gctacagaat tagatacaaa aaaaggatat ttatatgtat cttcaatgta
      421 tgctataaaa gaagcaaaat tagaaagtag agtaaacagt ggaagagtaa aacaatatga
      481 tggttaacat aatattatta attttcccta aaatattgaa aaatattatt atataagtta
      541 taatattaat atacacgtag atatttatta gttagatttg aggttggaaa aggcacccaa
      601 tacgctacta tagagtagtt aatagagatg caggatacgc cgccctgcca aatctaatta
      661 aattaaaaag agaggattaa ttcctctctt attgtttttt tgagatacta atttaatcta
      721 tatagaaaga ttgaaggtca tttatactaa aagttttcag ttatatacat taaactaatt
      781 aaataagata tttataatct atatgtgata catattatat attaataaaa gaaaaatata
      841 tagaaaatcc ttataaaaat ttaaattgta atgaatagga agtaattaaa aagaattttt
      901 attgattttt aaaaatttag ttagaaacta tatcattatg gtaaaaaatg tattataatg
      961 tttagaaata ttataataag gagcgattaa acatgaatct aacgaagaaa atagaagata
     1021 aaagaaaagc taaacagaga gctgaaaaag ttaagaaagc taaaattgct acagctggtg
     1081 tggtattagg agctgttact ggtgcagtga gtggagtact tttggctcct aaatctggaa
     1141 aagaaacaag agaggatata aaagatgctt cacaacaaat tgctgaaaag ataaatatga
     1201 aaactgtaga tgtaaaaggc aaagtatctg agaagctaga ggataaaaaa ggaaacttta
     1261 tagaatcaaa gaaaaaaata aaaaaatata tagataacaa aaagagtgtt gaaaattcta
     1321 gtgaggaaga taaaataata gatatagttg aaccagttag tgttactgag gaataatatg
     1381 gacaatacaa taacgattaa cataagtata atatatgtat tattagctat acttgcttgt
     1441 attgctttag tttatttaat tattgtactt gttaaactac ataagatttt aaataatgtt
     1501 ggaactatgt taaatgaaaa tactcaaaat ataaatacaa ctttaaataa tcttcctaat
     1561 gttgtagaaa cttttggaga agtaggagaa aatatgaaag atgtaacaga agtagttact
     1621 gaagttacag cagattttct tgttactaaa gacagtgtca aatcaaatat ggatgttata
     1681 gttgatatat tgactataat taaaaacatt tttctagata aaaaataata agttaatata
     1741 aaataagcct ataagatata atttaaacga ccttaaaata gcatttataa ggtcgttttt
     1801 tattagcttg atttgacact atgtgttttt aataattggt aatattcctc tttatcattt
     1861 gaacatatat atctatgctt gttgtttcaa ttacatccat aagaacatct ttacattcaa
     1921 gctcaaaatc ttccattcct tctaaatatt catcatcttc atcaaaaaag atataagaat
     1981 tatatagcca ttcttcaaat ttttcttcaa gtatatccca atacgaactc caaaataatc
     2041 cacaacctga tatataagat gctctacttt gatttatata aacctcattt agaagctttt
     2101 gtaatctact gctataaaga aaatctgctc ttccactgct tgatattaat tcatttaaat
     2161 cttctattga cattaattca actttaccac ttttatcata aggagtataa ttttcatcaa
     2221 cccatttatg tggtttgttt tctctgcata ctgttgctat caactctaca acttttgttc
     2281 ttatcatttt tttatcctaa cttatttatt ttttataaaa taatcatgat tttataattt
     2341 atctatttct tgtaatgcta atttaacagt ttcatatcta tcagcaccat ttattactac
     2401 atcacctttt acaagtttat tagcttctcc acctacaaca taaacctttt tacctaaacc
     2461 ttgcttataa ctagacgcct caattattaa agaatctttc aattgccaat gtaaaatctg
     2521 agcagccact ttatcagcat cacctgtata aacgattaca ttttcataca ctttattttc
     2581 ccctccccct tgagaatttg atatagattt gtttagtata ccttctgcta tcaatttagc
     2641 aactttatct ttattattaa cataataatc tgtatctgct ttactatcta caaaacatac
     2701 ttctattaat attgctggtg caatagtatg attaagccaa taaagacctc taacatcaga
     2761 ctttgcaccc ctatctttga atactgtagc taacctagta ttcactcttt ctgcataggt
     2821 tttgccatta ttagtcttat atattgtttc tgtccctact ggagttgaag ttgtagcatt
     2881 tgaattaaaa tgaatctgaa cagccaaatc agtttcctgt ttatttgcta tagcacattg
     2941 gtctgctaaa tgattacttg attcatcaac tcttcctgta taaacagtag ctccacctat
     3001 tttaagccat ttaacaatta agtcattcag tattcttgtt tctttgcttt cgtttatata
     3061 cccaacagct cctgtacctt ttccaattaa agtgtgccct ggtattatta ctactttcaa
     3121 actaacatct cctttacaat taaatttaac ttctatttaa tatatgcata acctagaatt
     3181 ttgtttcttt ttatatctta tacttttatt ataacctatt ttgtaaaaat atagaatatt
     3241 aagtaaataa tgttaaaatt ataattttgt atataagaca ttacttgatt gcaataattt
     3301 tatagcatat tcatctattc tatatccagt tctataatat atatgtttaa ttccagcttg
     3361 aattatagcc ttagtacaat ttaagcaagg aaagtgagtt acataaatag agcaattttt
     3421 aactgaaata ccttcttttg cacaataata aagggcattt tgttcagcgt gaatggttct
     3481 aatacaatgt ccatctctca tttcatgacc aacttcacta caatgcttat ctccagaaat
     3541 actaccatta tatccagtag acactattct gttttctgaa ttgacaatta tagctcctac
     3601 ataagctcta tcacaagttc ctctttcagc tactgtttcg cacagtctca taaaatattc
     3661 ttgccatgag catctatttt caagtttttt attcaaatta tatacctcca aaacttatat
     3721 ctaatatata agatttatac cttaaaaata atattaaaaa caaatttata cgataaataa
     3781 aatttattaa tactgttttt agtctaaatt atttcatttt aaattaaagt tacaaggaat
     3841 ctaaaattat atatatcttt cttcgtaata ttaatgttac aatataaaaa actgtctcaa
     3901 taaaatagag acagttttac agtcaaagtt tataatacaa gttcatattt ttctttaaat
     3961 tcttttacag cttcgggcca tgccttttgt tctgtaatac ctttttcttt agctatttta
     4021 attgcaatct ctcttatcat tgcagcgcct tctaatattc ccatttttaa tctcccttca
     4081 aatatctttt tgtatagaat ataaatagtg ctaagattta ttacatgctg catatacaat
     4141 atctatacaa cacataactt gtaaattcct tttattttca tacgtcttta accgacatat
     4201 aattatattc aataagtttt aaaattatga actcaattat aattattttt atttttttag
     4261 aatctaaaca ctaaaaattg taggtaaatt tgtcttatgc ctttataaat atttctacag
     4321 ttttaattac tggacatatc tatttttatt ataaaaagcg cttaaaaatc gagaatatcc
     4381 gcataaaaac tgtatataag caaaacggtt aaaggaaaaa gaagaaattt acttgaatgt
     4441 taaaatgcgt tgcttgaagc aatgggcagt tttgcctata atatcggtaa caactgaaag
     4501 aaaggtggtt agccctaatg ttaagcgaaa acattaaaac aatcaggaag tcaaaaggac
     4561 tttcacaaca agaacttgct ataaaactga atgtagtgcg acaaacaata tctaaatggg
     4621 aacaaggact gtcagttccc gattctgata tgttgatttc catatcagag gtgcttgaaa
     4681 cgcccgtaag cactttactt ggagaaacta ttgttgagtc ggaagttgat agcttaaaag
     4741 tgatttctga aaaattagag attataaact tgcaacttgc acaaagaaaa aacatgagaa
     4801 gaaaaatgtt tcattggtta tttattttat tatgtgcagt catattaata ggttttgtgg
     4861 tcttaggggg actaaatagt ccttacttgg attggaatta taccgaccct gaaaccgctg
     4921 tttttggagt agcttttcat gcttttgagt ggctatttgt cagattagta ccgattgtcc
     4981 ttataggagc aattattgga atctttgtga cacgtaagaa aatatgaagt aactctgctt
     5041 tttataatac agcaagcgtt ccttaaaagc gtcattctac atggcaatcg aggacgacta
     5101 tgtaaggaag aacctttttg atttccaact aagcgaagtt attgaggacg acagtaagac
     5161 caaaaccgca ttaagtaaag tacaggaagc aagactgctg gacttatact ctcatgcgtc
     5221 agatgcagga aatgcgaggt ctggtagcat gatttacaac gatttgtaca acgactgtga
     5281 gtagaaatat atggagataa gtattatcta cgaaatcaga aaagaaatga cttgataatt
     5341 tactcatgtt ataattattg atgtgaaatt aataaatcga aattcctttt ttggatttaa
     5401 caatactgag taaggaaaaa gtgaatgact tttgcaagga ggtgttaata tcaggcaagt
     5461 aaagtctttt gtttttccag ttatatcctt aatattctta gaccaaatta gcaaagttct
     5521 tataggatta ttcttaatgg actttgaaat tgatataatt gggaaatttt taagattcaa
     5581 tcctgttcaa aatacaaatc tctcttatgg gggaaacttt attggtattc tatctaattt
     5641 atgggtattg gtattgttta acattttagt tatattagtt attatatctg gatatgcttt
     5701 ttataaatca aaaaatgaac aaacaagcta ttcagtaaaa gtaattatgt cttgtggact
     5761 tgctggtaca atatgtagct tgatagataa attattttgg ggaggaagtt tagatttttt
     5821 gcagatacca agctttttta ttttcgactt aaaagactgc taccttactg ttgcagaaat
     5881 aatatttgtt gtcataggaa ttttgcataa tagagaaata tcaatgaaag aatacatata
     5941 tttttgctat cgtcagttta aaaaataaat ttagaagata aatttaagtt tcaaggtaaa
     6001 cttatttaat cacagcaaat agttggctta cttaagcttt tgggctaaac tgtgagaact
     6061 aattaagtct ctgctatcta acaaacagag cacaaaaata aaaattaaat attaaatata
     6121 aagcacagtt aattttgatt aaaaagttga ctgtcttttc ttttgtagaa atttaagcat
     6181 aggtaataaa gaaatgactg catttaagca ttatgtatat aattggaggc aataaaaagc
     6241 cagcaaagcc cataaaatag agctgtgcta gcaacatgat gagttataag aagataatca
     6301 aaaacttacg ctttatttta atttaaaaaa atgattactg taaagaaatc attttttatt
     6361 ataatcactg atacatcaaa tattctaaat aaaattttta tttatctgga attgtatatt
     6421 ttttctataa tattaactac agcgtacatt gcccaagcac agatagccaa tacaaatact
     6481 cccatcatta ctaaatctaa tttaaatact tgagaaccat atactatcaa gtagcctatt
     6541 ccatatcttg aaactaaaaa ttctccaact attacaccta cccatgccat accaatatta
     6601 attttagtta aatttattaa atttcctgtg tttgcaggta atatgagttt aaataatatt
     6661 tgagatttag tagctccaaa gctttttaac atcttaattt tttcttcatc tatattcata
     6721 aaataattat aagctgaaag tatagtaaca acaacagaaa tcgttacagc tgttacgacg
     6781 attccttcta ttccagcacc tacccaaact ataattatag gagctaaagc agtcttagga
     6841 agagcattta aaactaccaa aaatgggtct aatatttttg ataatttttc tgaccaccaa
     6901 agagcaattg ctaccaaaat acctaataca gtacctataa caagaccaag aacagtttca
     6961 tatacagata ttccaatatg tttaaataat tgaccactaa atgcatattg aataaataaa
     7021 ttgtaaatat cacttggttt gctaaataga aatgtattta taacatttaa gtcagctaaa
     7081 agttcccaga ttacaataaa accaattaaa attaatagct ggtagaataa tacatttctt
     7141 ttttctcttt ttacaccttt aacatagttt atatatcctt cagatctttt attaagcctc
     7201 atgtgtatct agctccttcc ataatatgtc gaaatacttt tgaaaatcag gaactttacg
     7261 tgttttgaga ggcgtttttg ttccatccat gttaagttca atatcgtaaa tattttttat
     7321 ggtagctggt cttttagata gtattgcaac cttatctgat atgcttattg cttctgctat
     7381 agctaaaaaa gtgcaactaa ttgcttaaag aaacagaatt atccacttca gcacccatat
     7441 aaacaatatt aagatttcct aaactgctat cccaaacgat actattaata atagtagata
     7501 ataacaatct cttatcatct aaactggcat tatcaacttc atcattaaat ctcttcaaat
     7561 tactaacaat aatatcaata ttaatactgt cactactaat attgatgtta ctagattcca
     7621 aaatattaat cttatccttt aaaatactaa tctcattatt taggctctca atctgggaaa
     7681 ctatataatc agaagcagta ctaccagtat tttttgcaag ctctataact aaatttttaa
     7741 taagtctttc cttatctaaa atttgatttt taagtaaatt agtctcagat ttaaaaatat
     7801 taaaaacatt atcagtctta atgttattac tattgaatgc acttataata gactcttctt
     7861 tacaattctt aattttatct ataactaaac tttcaactaa tggaccatta agatttttac
     7921 agttgcaact atcagaccca agtgtttttt tagtaccaca aatataataa tactttaaat
     7981 ccttgtcagt ttttttgcct ttataggtaa ttctcatatt agaaccacat ttaccacatt
     8041 ttataagacc agataaaaga gcagtttttc cagttgatat ccttggagtt ttatcacgat
     8101 ttttatctaa ttgattttgt acttcaagcc atatttcagg ttctatgact ccatggtgtt
     8161 ttgcaattgc tgctattgag ttagatgtat ttttagcata agtaaggatt ccacattttc
     8221 tatctggagt acctacaaca tccataccac tatttttaag gtaatctaaa atttcatcat
     8281 tagcttttac atatgctgga tttctaagta ttctagataa agaactaggg tcaaatttac
     8341 caccacgagg accccttatt ccattattat agacatattt atataactta gataaggacc
     8401 taagttctaa atatttattg tatattagct ttacaatctc catttgttca tcatttactt
     8461 gaagcttata catacttctt tcttttagat tttcatctaa gaatgtgatt ttttcactgt
     8521 tgaatccatg aggtgtattg cctccaagcc atctaccact acgggctaat tcatacatat
     8581 tgtcttttat acgttctgct attgtttctc tttctaattg agcaaataca cttgatataa
     8641 acatcatagc tcttcccatt ggagttgaag tatcaaattg ttctttgata gatataaatg
     8701 atatgtttag ttcatttaat ttttctatta aagtagagaa gtcagataca tttctcgata
     8761 tcctatctaa tctataacaa actaggtaac taaatttctt atctttggca tcctgcatca
     8821 ttttcttaaa ttgtggtcta tctatattgc taccactaaa tccctcatct tcatatatca
     8881 aaaaatcttt tacaccaata gactttgcat aatcaataca taattgtatt tgattttcta
     8941 tagaatcacc ttttccagta aatcttgatt ttcttgaata aattgcagct ttcaaaatta
     9001 aaacccccta taagttagga tatatatttg aaattattta tatacaacct tttaagtaaa
     9061 cttattagaa tgaatttatt aattaggtaa atttatataa ttctactttt tataatatat
     9121 gactatttat tttatttctt tactattcaa gttctaaatc aataataaat tttgatattt
     9181 aattgtatca ggacaaatct ctaatttcat agattattaa tataaaatca taggttagtg
     9241 tgaaaaagtt gaaatttaaa tattttaaaa gataattttt ttgaactaat aggtataaca
     9301 aaaatttata gggggattgc atatggaaat caatgttata gaaattttcc ctaaagataa
     9361 agctaaactt aataaaatag aaatggataa agctagttgg tttgtaaata taataagtaa
     9421 aaaatatcct aaagaagctt taaatgaagc atttagtact ttagaaaaag aattaaatat
     9481 aagtaaagct aatacataag ctttgattat tgattttata tactattggt tttatacgct
     9541 atgacttgac attatattaa tcaaatagta tatttttaaa tatagcacaa tgaagtgtta
     9601 aaagagcaat ggagctccat agataaagtc tatggagctt ttttgcgtat ttaacttaag
     9661 gaggatagga ctttgaataa ctttgagatt aaaactagaa taaaatttgg agaaggctca
     9721 ctaaaagctt tgcaagaatt aaaaaacaaa aatgtactaa taataacaga cccttttatg
     9781 gtgaaatcaa aaacaataga taaaataaca tctaatttaa taaactcaac atatcaagtt
     9841 tttgaagaaa tagtaccaga cccaccaata gaagtagtag tagcaggaat agaagcattt
     9901 aaatctataa atccagacgt aataatagca ttaggtggcg gttctgcaat agatgcagca
     9961 aaatctataa tggacttttc taaaaaaata ttaaaaatta acgaagtaga gtttatagca
    10021 ataccaacaa caagtggaac aggttcagaa gtaacatcat ttgctgtaat aacagatagt
    10081 caaaaaaaat gtaagtatcc attagtgagt gatgatttac ttccagatat ggcaatacta
    10141 gacccagagc ttgtaaaaac tgtaccaaat tttataacag cagatacagg gatggatgta
    10201 ttgacacatg ctatagaagc ttacgtatct acaaattcta atgacttttc agatgcacta
    10261 gctgaaaaag ctataaagtt agtatttaaa tacttaataa aatcatataa agatggaaat
    10321 gacatagaag ctagagaaaa aatgcacaat gcatcttgtt tagcaggtat ggcatttaac
    10381 caagcatcac ttggcataaa tcattctatt gcacatgtat taggtggaaa attccatata
    10441 ccacatggaa gaacaaactc tatattactt cctcatgtaa tagaatataa ttcatcaata
    10501 gtaggatata ctaacacaac ttactctgat acagctaaaa aatatgcaca aatagcagaa
    10561 ttagtaggac ttgggagtgc taatataaga atatctgtta gaaatttagt aaatgaaata
    10621 aagaaactac aaaaagaaat gaatatgcca actaaattga cacaatgcaa attaagttta
    10681 gaagatataa ctaatgaaga aagagaaata gcaaaacttg ctataaaaga tacttgtaca
    10741 ttaactaatc ctaaggtacc aactgaagat gatataataa acatattaaa gaacattaaa
    10801 taactacatt ttattacatg taaatataat attatacaaa tagggaaaat gtttttaaaa
    10861 atataaatta tatattgaca aatataaaac ataaaactat aatgaaagta tcacaaaggc
    10921 gtgatacttt agtagaaagc aatggagctt cttaggaata ttaatattat tcttatggag
    10981 ctccttttat tttaatcaaa tagcttttta ataaactata ttcaaagaaa gcagggaata
    11041 aatttgactg aagaatctaa gcaaagagtt attcaagaat atgttcctgg aaaacaggtt
    11101 acattagcac atatcatagc taaccctaat gaagacatat ataagaagtt aggattagta
    11161 cttgataaaa aagatgcaat aggaatactt acaataacac caagtgaagc gtcaataata
    11221 gcagcagatg ttgctacaaa ggcttcaaat gtatctttag gttttataga tagatttagt
    11281 ggttcagtag taatatcagg tgatgtaagt tctgtagaat cagcgttaaa tgatgtttta
    11341 gaagtcttag gaaatatgtt aaacttctca tctacaaaaa tcacaaggac ataataatac
    11401 aatgaagaat ataatattta tgggaaagac aggtagtggt aaaactacct tatgtcaaaa
    11461 actagaccag ttagaattaa agtataaaaa aactcaatca gtggaacttt ataataatgc
    11521 aatagacact cctggtgagt atatggaaaa tagaaaccta tataatgcct taataacaac
    11581 atcagcagat gctaaaatta tagcaatagt gtatgatgcc acacaagaag aaaattatat
    11641 agcaccaggt tttgccagta tgttttgcaa agacgtaata ggaattataa ctaaaataaa
    11701 taaagctact gaaaacgaag tcaatatagc ttatgaaaga ctatcactag caggagcaag
    11761 tcaaatcttt aaaatagaca cagttgataa tattggactt gaaaaattat ttaaatatct
    11821 agaaaaatat aaaaatatag atgaagttta aggggaaata tttttttatt caaaaatatt
    11881 attaaagtat gataaaataa aaaaatgtat aaactatttt aagaagattt aatctttaag
    11941 cgaggtagga acatggggaa aaaaatacta ttggttgatg atgaaccact gttaaggatg
    12001 gatacaaaag atatattaga aagtcatggc tatgaaataa taggcgaagc aagtgatgga
    12061 tttgaagctg ttgaaatgtg taaaaaacac aaacctgatt tagttataat ggatatagag
    12121 atgccaatac ttgatggtat aaaggcaggc aaaataatat gtaaagaaaa tctagctggt
    12181 ggagtacttt tattaacttc atttgaagat aaagaatacg tagaaaaggc taaaagtata
    12241 ggtgcttatg gatatttagt aaaaacagca agtgaaaaat cacttatccc aaccatagaa
    12301 atgtgtttaa ataaggtaaa tgaatttgaa aaaatgaaaa aagatttaga aaaagtaaat
    12361 tctaaattga atgaaagaaa attagtagaa agagcaaaag gtatacttat aagagagttt
    12421 aagatttctg aggatgaagc atacactaga ataagaaaat taagtatgga taaaagaact
    12481 acaatgatgg aaattgccaa aatgattata ataggatacg atgactaata cgataaaaaa
    12541 aatatcaact gcacaaacat acttaaataa taacgaaatt gaaaaaatta tagaagtatc
    12601 aaaatcctta gatttaatgg cttcttttta tgaagctgat gtttttatag atgtactaag
    12661 taaatttgat gatgaagcaa ttgttgtggc acatggtaga cctaaagaaa agtcaatgta
    12721 ctgtgaaaat gttataggta aaaaggcttt aattgaaaat gaaccaggag ttataaagtg
    12781 cttaaaaaca ggagaaagag taagagatat taaagcttta acacaggaat ataaactggt
    12841 caaacaaaat attcagccaa taacactaga tgacaaagtt ttagcagtac taatagttga
    12901 aaaagatata agtagtgaag ttaagaatga gtttaatgct agtgaagacg aagaaaataa
    12961 aaatttacat cagtttataa aacttattgg aaataatgac tttttagttg ataatttaaa
    13021 ttcagccata ttaatatttg ataaaaatgg aaaattaaaa attaaaaatc gtattgcaac
    13081 tgagatatac aaaaatcttg ggtttggata tgatatacaa gatatgcatt acaatgattt
    13141 agatatagaa accaacacct ttgaaaatat attaatggat gaaaattatg atgagacaaa
    13201 tgaagtttca ataggtaata tgttttttaa aataaagacc atatacatca aagatgatga
    13261 atttaaggtt tgcaaaatag tacaagatat aagtgattta aagagaaaag aagaagaatt
    13321 agttttgaaa acagtggcta taagagaagc tcatcataga gtaaaaaata atcttcatac
    13381 agtaatatct ataataaaaa aacaaagtag attatctcaa aatgatgaag taaagcagtg
    13441 tttagataac ataataaata gggtatttgc aatactttcg actcattatt tactatctaa
    13501 agaagttgat aataatatat ctatacgaga aggtatcaat ttattagtgt caaatattca
    13561 aggtggctat ttatttagta aggatataga tatacgtata actggtgaag attttaaaat
    13621 tagtggagaa aaagcaacag caatactttt ggttataaat gaaatactac aaaattgtta
    13681 tgaccatgca ttttcggata gagaacatgg tactatacaa atattaataa ataaagataa
    13741 cgactataga aatattgcta ttatagatga tggaattgga tttgatagta ataatataaa
    13801 taaaaatagc ttagggacat atataataga tagttatata acacagatgt taaaaggaaa
    13861 tatagagaga aaaagtagtg agaatggtac agaagtatta attactatac ctacacaaat
    13921 taatatttaa ataataactc atctacaaag tagtagtttt aattgagcaa agaggcttaa
    13981 ggttattaat agattaagtt aattgaatgt atttataaaa attataagta tatattcaat
    14041 ttaacaggta tttattataa ctttaagcct ctttgcttgt ttaagacata cttaaatttt
    14101 aggaggtgag aaaatgagag aagagttatt aagtgttggt attgacattg gaacaagtac
    14161 tactcagtta attttttcta aattaatagt agaaaatact gaatcaaatt tttcggtacc
    14221 tagaataagt atagtagaca aagaaattat ttataaaagc aaagtttatt tcacccctct
    14281 tatttcaaat aatgaaataa atggtcaaca aataaaagat atagttgaaa atgaatataa
    14341 aaaagcaaat atatctaaag aagatataca tacaggagca gtaataataa ctggtgaaac
    14401 agctagaaaa gaaaatgcaa atgatgtact tcatactttg agtggatttg ctggggactt
    14461 cgttgttgca acagcaggac ctgatttaga aagtataata tcaggaaaag gagctggagc
    14521 tcatatttat tcaaaagaac attcaactac aattgtaaat atagacatag gtgggggaac
    14581 tagtaacata gcctcattta aaaggggaga agtaaccgat actggatgtt tggatatagg
    14641 tggaaggctt gtaaagatag ataaaataag taaaaaaata acttatatat cacctaaaat
    14701 agataaaatc ataaaagata ataatttaaa tcttcaagta ggcacaatgg ctactgtaga
    14761 aaatacaaag ccaatagtgg atataatggt tgacttatta atggaaagca taggattaaa
    14821 gaaacagaca cctttgtttg attttataat aaccaataaa tcaataagta tagatgaaac
    14881 tattaaaaat gtttcattct ctggtggagt agctgattat atttactatg atggagaaat
    14941 aaaagattat tttgaatatg gtgacttggg aattttactt gggcaagcaa taaaaaattg
    15001 tgaatacctt aaaaaagtaa atgtagttaa atctatggaa acaataagag ccacagtggt
    15061 tggagcaggt tctcatacta ctgaagtaag tggaagtaca ataacttaca ctagcgaaaa
    15121 gtttccactt aagaacttgc cagttttaaa attatcaatt gatgaagaaa caggtacttc
    15181 aaaacaaatc agtgaagcta taaaaaataa acttaattgg tttaaactag aaaatgattt
    15241 acagaaagtt gctatagcca tgataggaaa gaaaaatcca acctttttag atatacaaga
    15301 gtatgctaaa gggtttgtag atggaatgca acaaatcata gaaaatgatt taccttttat
    15361 agtaattgtt gaaaatgata tggcaaaagt gttaggtcaa gcaatatatg cattattaaa
    15421 ttatgaaaaa gaaattgttt gtatagacag tgtcaaggtt gaaaatggag actatatcga
    15481 cattggaaaa cctatagttg aaggtaaagt tttacctgtg gtaataaaaa cattagtttt
    15541 taattaatag aaggaggtaa gtaaatgatt ttaaatacaa aattatttgg acgtacttat
    15601 cagtttaaag gcttatatga tgtaatggct aaagctaatg aagaaaaatc aggagataaa
    15661 ttagcaggtc ttgcagcaga atcagctgaa gaaagaatag cagcaaaagt tgttttatca
    15721 cacataaaat tggaggatat aagaaataat cctgcagtgg catatgaaga agatgaagta
    15781 acaagaataa tacaagatgc tgtaaatgaa aaagtttatg aagaaataaa aaattggaca
    15841 gtctctgaac ttagagaatg gctattggat tcaaatacta caagtcttga tataagaaga
    15901 atatcaagag gattaacttc tgaaatgata gcagcagttg caaaattaat gtcaaatatg
    15961 gacttagttt atgcagctaa aaagataaag gttactgctc actgtaatac aactatagga
    16021 gaacaaggaa cattatcagc aagacttcaa cctaatcatc caacagacga cccagatgga
    16081 atacttgcat cacttcttga aggtttaact tttggtatag gagatgcagt acttggatta
    16141 aatccagttg atgactctgt tgagagtgtt actaaagtat taaaaagatt tgaagaagta
    16201 aaacaaaaat atcaaatacc aactcaaaca tgtgtattgg cacacgttac tacacaaatg
    16261 gaagcaataa gaaatggtgc tcctgcagat ttaatattcc aatctatagc aggttctgaa
    16321 aaaggaaatg aagcatttgg atttaacggc gacactatag aagaagctag acagttagct
    16381 ttaaaacacg gtacagctac aggacctaac gttatgtatt ttgaaactgg acaaggttca
    16441 gaattatctt cagaagcaca tcatggaata gaccaagtta ctatggaagc tagatgctat
    16501 ggatttgcta aaaagtatga accattctta gtaaatacag ttgttgggtt tataggacct
    16561 gagtacttat atgatgctag agaagttgta agagcaggac ttgaagacca ctttatgggt
    16621 aaactacatg gcttaccaat gggtgttgat gtttgttaca ctaaccatat gaaggctgac
    16681 caaaatgata tggaaaactt agccatacta ttaacaacag caggatgtac gtattttatg
    16741 ggaatacctc atggagatga tgttatgctt aactatcaaa caacaggata ccatgaaaca
    16801 gcatcactta gagaaatgtt tggactaaca gcaataaaag aatttgatgc ttggatggaa
    16861 aagatgggat tctctaaaga tggtaagtta acagagttgg cgggagacgc atctgtatta
    16921 ttaggatagg aggtatttaa tatgaatgag aaggatttaa aagcattggt agaacaatta
    16981 gttggacaaa tggttggaga attagatact aatgttgtgt ctgagactgt taaaaaggca
    17041 actgaagttg tagtagacaa caatgcttat atagatgata taacagaagt tgatataaga
    17101 aagcaattac tagtaaaaaa tcctaaggat gcagaagctt atttagatat gaaagcaaaa
    17161 acacctgcaa gattaggtat aggaagagct ggtactagat ataaaacaga aacagtttta
    17221 agatttagag cagaccatgc tgctgcacaa gatgctgtat tctcttatgt agatgaagaa
    17281 tttataaaag gaaataatat gtttgcagtg gaaactttat gtaaagataa agatgaatac
    17341 ttaacaagac cagatttggg aagaaaattt tctccagaaa ctataaataa tataaaatct
    17401 aaatttggta caaatcaaaa ggttttaata ttagttggag atgggcttag ctcagctgca
    17461 atagaggcaa atttaaaaga ctgtgtgcca gctataaaac agggtctaaa aatgtatggt
    17521 atagattcaa gtgaaatttt atttgttaaa cattgtagag ttggtgctat ggaccactta
    17581 ggtgaagaat taggttgtga agttatatgt atgttggttg gagaaagacc aggattagtt
    17641 actgctgaat caatgtcagc atatatagct tataagccat atataggaat ggcagaagca
    17701 aaaagaacag ttatatcaaa tattcacaaa ggtggaacaa ctgcagttga agcaggtgct
    17761 catatagctg aacttataaa aactatgtta gataaaaaag cttcaggaat agaccttaaa
    17821 taaagtcgag ggagtgtaga atatgaaaaa tgatgtaatt cgtcctaata tactaggaat
    17881 taaaataatt tcaaatataa gtccagaaat ggcacaaaaa ctagaattaa aatcacatca
    17941 caaaagctta ggtttaataa ctgcagactg tgatgatgtt acgtatacag ctcttgacga
    18001 agcaactaaa gcttcagaag ttgatgttgt atatgcaaaa tcaatgtatg caggtgctgc
    18061 aaatgcttca acaaaacttg ctggtgaagt attaggaata atagcaggtc caagcccagc
    18121 agaagtaaga agtggtctaa atgcagtagt tgattttcta gagtatggag caacttttat
    18181 aagtgcaaat gatgatgatt caatagcata ctatgctcac tgcgtatcaa gaacaggtac
    18241 atacctttca gaggtagcag gaataagaga aggtgaagca ttagcttatt tagtagcacc
    18301 accccttgaa gcaatgtatg cactagatgc agcaatgaaa gctgcagatg ttaagatgtg
    18361 tgaattattt gcacctccaa ctgaaacaaa ctttggtgga gcattactta caggttctca
    18421 atcggcttgt aaagcagcat gtgatgcatt tgcagaagca gtaaaatcag ttgcagacaa
    18481 tccaacagga ttttaaggat agttagatgg atgctatagg cttaatagaa gtaataggat
    18541 atgttgctgc aatagaagct tctgatgctt gtttaaaatc tgcaaatgtt aatattgtaa
    18601 gagttgataa ggttggggca ggtattgtta ctttaacaat atgtggagat gtcggtgctg
    18661 taaaagctgc tttagaagca ggtgaaatag cagcttccag agttggtaca ttaagaacat
    18721 cacatattat accaagaatc cataatgaag taacaaatgc tttattcaaa actaaagaac
    18781 ctaaagtctg tgaagtttca gaagataaag aaaaaaactt tgagattaca ttggaaataa
    18841 ctgataatgt atcgaaaaat ttatcagaaa aagaaaatgt aattttagat gtcaatgaaa
    18901 atagcggaaa tactgaaaat ttatatagtg atatagataa aacaaacaaa aaaattgaaa
    18961 cagttgatga tagtttaaca gaagctaatg aggaaaaaat agaaaacact aatgataaag
    19021 aagtattgga acaagttaaa atagaaaatt ccgattttga tagagatgac ctatcaaaga
    19081 acagtgtaaa aaaacttaaa gctatggcta agaaattaga ttcttcaata acttataaag
    19141 atttaaatgt tcttaaaaaa gaagaattaa taaacttagt taaaaagctt agcagaaggg
    19201 atagatagtt atgacacttt tagataaaga tttagtatct atacaagaag tcagaactct
    19261 tgtaagaaga tctaaagtgg ctcaagagaa actttctaaa atgagtcaag agcaaataga
    19321 taaaatagta aaatctgttg tagatgcagc atttaataat gctactaaat tagctaaaat
    19381 ggcaaatgaa gaaactggat ttggaaaatg ggaagataaa gtaattaaaa atacttttgc
    19441 atctatggga gtttatgaaa ctttaaagaa cacaaaaact attggaataa ttggtgaaga
    19501 taaagaagcc aatacgatag atatagctac accagttgga gttgttgcag gtcttatacc
    19561 ttcaacaaac ccaacatcaa cagtaatata caaaactata atatctctaa aagcaggaaa
    19621 tactatagtt ttctctccac atccaaatgc aaaaaactgc atacttgaaa cagttaatat
    19681 aataagtgag gctgctataa aggctggagc tccagaggat tcaatattat gtataactaa
    19741 tccaagtata gttggaacca atgaattgat gaaacataaa gatacaaact taatactagc
    19801 aactggagga gaagcaatgg ttagagctgc ttactcttca ggaacaccag ctattggagt
    19861 tggaccagga aatggaccag catttataga taaatcagca aatgttaaat tagcaatcaa
    19921 aagaataata gattctaaaa cttttgataa tggtgttata tgtgcatcag aacaatctat
    19981 agtaatagaa aaatctatgg aagaaactgt tttaaaagag cttaaaaatc aaggtgcata
    20041 tgttttaaat gaagaggaaa gtgaaagatt agcaaaattc atattaagag ctaatggtac
    20101 tatgaatcca caaatagttg gtaaaagtgt tgaggtaata gcaaatttag cagacttaac
    20161 aaatgtacct aaaaatacaa aagttctagt tgcaagagaa aataaagttg gtcacaatgt
    20221 agcctattca agagaaaaac ttacaccaat actagcgttc tatgttgaag aaaatgtaga
    20281 agctattatg aacagatgca gagaaatatt gttaaatgaa ggtgcaggtc atacattctc
    20341 aatgcatgta aatgatgaag aattggtaaa aagatttgcc cttaatatgc cagtatcaag
    20401 aatacttgtg aatactcctt cagcacttgg aggaataggt gcatcaacaa accttgtacc
    20461 agcactaaca cttggttgtg gtgcaatagg tggaagttca acttcaaaca atataggacc
    20521 acttgattta ataaatgtta aaagagtagc ttatggaatc aaagaaatag aagaacttgg
    20581 aagagataaa tctcaagttg aaaaatcaat gtttgactca atggataaag aagaattaat
    20641 aaatcttctt gttcaaaaac tagtcaaaga actagcataa ctaaaataaa caatgaaact
    20701 tatagctatc actataaatt tctaaaaata taaactataa aaaactataa aattaaattt
    20761 ttggaggata agattatggc aagtgcaaac gcattaggaa tgatagaaac taaaggatta
    20821 gtaggagcaa tagaagcagc agatgcaatg gttaaagctg caaatgtaca attagtagga
    20881 aaagagcaag taggtggagg attagttact gtaatggtaa gaggagatgt tggagctgtt
    20941 aaagctgcta cagatgcagg agctgctgct gccgagagag ttggagaact aatatcagtt
    21001 catgttatac caagaccaca ctttgaagta gatgctatat taccaaaggt atcagctgag
    21061 taatataaga ataattataa aatttaaatt ttgattgaaa aagaggctat ctcaaaaatg
    21121 agtcttacta ataaactcaa tgtattttga ggtagtcttt tttatacatc taataggaga
    21181 tgtgataaaa tgggtgtttt aacagaaagc gaagtaaaaa gaaaaattgg aaaaaacaaa
    21241 aataatataa ctgaatttta tatagaaaaa ggtcaaataa taactccttc tgcaaaatct
    21301 tatttagctg agagaagtat tgagcttaaa tatgttgata aactttcaga tgtaaacaat
    21361 gaacctaaag aagttgtaaa agaagtagtt aaagagaaaa aatatagata tactactgta
    21421 tttggcgcta aattggatga aaaaccagaa catatgactc aattaaatgg aaatctttta
    21481 gtttttaaag accataaaag aataatattg agaggaaaaa tagattctct tgaatcagaa
    21541 atactaaagg tacagatact ttgtcagaaa ctagatatgc caaagcttgt taaggaattg
    21601 caagaagtat tagactttgt aagaaatata atgagatgtg aagttttaga tgaaaagcta
    21661 ggggacttta aacttttagg attaactcct caagaactta gagaacaatc tcactatcct
    21721 aaaaaatact ttggtatagg acatgagttc ccaagttatg aaatgggaga agtagtagta
    21781 gctataaata gtataagaag taatacacga gaggttgaac ttgcagccta tgaagcattt
    21841 aagggtgagt atggaaatgt tcacagagaa gatttaataa aggcacttaa tagattatcg
    21901 tcagtatttt ggataatgat atataaggtt agaactaata agtataagta gttggaggac
    21961 ataatggaga atctattaaa tgaaatagtg gaagaagtaa taactagagt taaaaaagaa
    22021 gcatttatag aagttgaagc atcaggaaga cacgttcact taagtagaga agatgtcgat
    22081 aaattatttg gagaaggata tactcttaca aaactaaaag acctatctca accaggtcaa
    22141 tatgcatgta aggaaagagt tacaataact ggtcctaaag gaagtataaa aaatgtagtt
    22201 gtacttggac catgtagaaa tgaaactcag gtagaaatat ctttaacaga tggttcaact
    22261 cttggactaa aagctcctat aaaacaaagt ggagacttag aaggtacttt aagtattaaa
    22321 atatcaacac aatatggtga agttgaactt gataaggggt taatggttgc taaaagacat
    22381 atacacatga ctcctaaaga tgctgaaaaa ttcaatgtat gtgataaaga gatagttgaa
    22441 gctaaggtga tgggtcaaag acctttaaca tttgatgatg tagtaataag agtgagtgac
    22501 agttttaaaa cttatatgca tatagactat gatgaagcca atgcatgtgg ttattcaaaa
    22561 ggaactgttg ctaaaataat aaagaaagcg taaatttaac ctactatata aattacctct
    22621 agggaggatt taatatgaat tatgataacc ttgtagattt aataacggaa gaaatctata
    22681 aaaaaataaa tagtaatgaa ataaaaatat ctaataaacc taaagctgtg attgtatttg
    22741 aacaagataa caataaattt aacttattaa aagatgaatt tgaaatagta gaatttgata
    22801 aaagtataag ggaatgtgaa atagtgatag tttcaagact ttgtatgagg gggctatcga
    22861 atatagcact tggaaattca acaagtgatg aagaaagatt tatactaaaa atgattatga
    22921 agggcaaaga agtatatgtc ctagatgaag gaattgaata caaaaaatat aaggatactg
    22981 caccaaaagc attatataag aaatttatgt catttgaaga tgaaatatgt aaatttggtg
    23041 tagaaattat aaaagactta aatgttataa ctaaaaataa gttaaatata aagaaagaac
    23101 tagaaagtac tagaggttct aaaaaagaag atacaaaagt tttagataaa gatgttttaa
    23161 atttaatcag tgtagaaagt gtaaaaatag ataatgaatt tagtttagat ttaaggaata
    23221 aaaaacttat atcggaagct gacttaagaa aaccaactat aaatggagtt aaaaacatat
    23281 tagttaataa aaaaagtata ataacaccat tagctgtaga ttttatgaga atacaccatc
    23341 tcaaactaaa gaaagtgtaa ggaggtaatt ttatggatat aggaaaagtt gtaggtaatg
    23401 tttgggctac aagaaaagat gaaaaattat gtggccaaaa acttttagtt gtaaaaattt
    23461 taaaaactaa agacacatac aaggaaggct tcatggttgc agccgataat gcaggagcag
    23521 gaaatggaga cttagttctt atatccaaag gttcctcagc tagagagtcg attgaaaaat
    23581 ctcatgttcc ggtagatgca actatagttg gagtagtcga ttcgtttgag gtgtttgatg
    23641 aataaaagta taggagctat agagtttaaa agcattgcta aaggtataga agtatccaat
    23701 gaaatgataa agaaatcttc agttgatgta ttgtacttaa aaagtatttg cccaggtaaa
    23761 tttctaataa tagtaggtgg agaaacttct tatataaatg aatgtgtaga ttatggaata
    23821 aaacttggag aaggatatat tgtagataac ttcgtaataa atgcaatttc acaagaaata
    23881 ttagatggat ttaaaaataa gtatcaaaag ctagatagta tagtctctat aggcgttgtt
    23941 gaaagtagta aagtatgcgc tggaataaaa atgcttgata agactttaaa atctggcgac
    24001 ttagtattag taaaacttca attatctttt gctataggtg gcaaattagt atatatagta
    24061 gcaggagatt taagtagttt agaatatgca ttaaaagaaa gtgaaaatgt agtaagagaa
    24121 aaagaagtaa tatataagac tgtaatacca tcagtagaca gtcaaataat aaaaagtcta
    24181 ataaaataat ggggggaatt atgagtataa acgaaattat aatctatgta atggtagtct
    24241 tcatggtact tggagctata gataaatgta taggtaacaa atttggtctt ggagaacaat
    24301 ttgaagaagg tataatggca atggggtcac ttgcagttgc aatggttggt gttatatgtt
    24361 tagcaccagt tcttgctgat gtattaagac caattgtagt accagtattt aatatacttg
    24421 gagctgaccc agctatgttt gctggaagtt tattagctaa tgatatgggt ggtgcaccac
    24481 ttgcacttga acttgcgaaa gaccctaatg ctgggttatt tggtggatta atagtagggg
    24541 ctatgatggg acctacaata gtatttataa taccagttgc gcttggaata attgaaaaag
    24601 aagaccaaaa attcttagca acaggaatac ttgcaggtat aataacaata cctattggag
    24661 cattcgttgg tggattagtt gcaggattcg aggtaatgat ggttcttaga aacttagtgc
    24721 caataataat atttgcagta gttatagcac ttggattatt aaaattcgaa aatgctatga
    24781 taaaaggatt cacatacttt ggaaaaggtg tagtaatagt tataacttta ggacttgctg
    24841 ctgccatagt tgaagcttta acaggaatag ttgtaatacc tggaatgaaa ccaatcagtg
    24901 aaggtataga aatagttgga gatatagcaa tagttttagc aggagcattc ccattagtgt
    24961 ttgttataac aaaggtattt aataaaccat taatggcttt aggaaaagtt cttggaatga
    25021 atgatgtatc agcagcaggc cttgttgcaa gtttagctaa ctgtatacca atgtttggta
    25081 tgatgaaaga tatggacaat agaggaaaaa taataaatgt agcattctct gtatcagcag
    25141 cattcgtatt tggagaccac ttaggattta cggcaggatt taattctaat atgataacac
    25201 caatgatagt tgctaaatta gttggtggta taacagcagt attgttagct atggttatcg
    25261 caaataagac actaaagaag gagaatgtat aagatggata tatcaaatat agataaaaat
    25321 ttaattgaaa cattagtaag acaaataata gaagaaaaaa taagtggaac taaagacaca
    25381 gtagattttg ttagaaataa agacattagt ggaataactt ctataaagtt accaactgta
    25441 aaagttagtg aatctgatag attagataca gggaatccaa gtgatgtagt ttacacaaaa
    25501 gatttattta cattagagga aagcccaaga ttaggttgtg gtatgatgga aatgaaagaa
    25561 acaacttttg attggactct aaactatgat gaaatagatt atgtaataga tggaacttta
    25621 gatataataa tagatggaag aaaggtttct gcttcttcag gtgaattaat atttatacca
    25681 aaaggaagta agatacaatt ttctgtacct gattatgcta gatttatata tgtaacatat
    25741 ccggcagatt gggcatctca aaattaataa aaatcaagtt aagttaataa taatcaaata
    25801 aataatttaa aatacaaact cttaaataag cacacatatt taaaaaagct atgaattaaa
    25861 attcatagct ttttttataa agaatgttat attttagacg tattttttct atatttactg
    25921 ggagacatat tatatttttt attaaataat ctaataaaat gctctacatt tggataacca
    25981 atactatttt actgataatc ttttccttat cactaatctt acattttaaa atattatttt
    26041 tactcgtaat attatcataa gaatttgttt cttatttaaa actaattaga attataaagt
    26101 ttattgccat gttattaata aaataaatcc agttaaatcg agtgctagtt aaagtaataa
    26161 gaaactttta caatggtttc ctttatcgat tgaaataaaa gttaatatgg tataatatct
    26221 aaagagagaa tcttatcaat tagaatatgc atagaaacaa gtggcttaaa aggagacgtt
    26281 atatggaaga gatagtaaag aaggaacaag caagtatgaa tgatattttt ttgtatctta
    26341 aagctaaatc aaactcatta tataaatttg taatattata taatgagttt atcaataaac
    26401 ctaaagatta tggaactggg gaacttataa acatggttga agtacatatg ctaacagcga
    26461 ttgaagaaaa tccaggaata agtccaactc agttagctaa aatatggaac agaactaaag
    26521 gtgcaatatc tcaaactata tctaaattgg agaaaaaggg ttatataact aaagaaaaga
    26581 aagaaggaaa tgcaaaaact atattactat atccaaccac atcaggagta gagttaagta
    26641 aggcacataa actatatgac accatagatg ttacaagaac atttgaatac ttaatcaagg
    26701 agtgtacatt agaggagata gatagttttt ataaagtaat tgatttgttt attaatttat
    26761 tagaagaatc tccgcaggaa aataatgatt ctgaaaaagt gtagctgaga ttgaagttga
    26821 ataaagagaa atagatatta tagaagtagt acttaagtac acattatata aaaatataat
    26881 aggtatagga ttaaaaagtt tagtggttta aagtttaacc actaaacttt tttaatgtct
    26941 ataatctact attatttaat ttactaaaaa taaaaaaact cattatatta agataaaaat
    27001 agaaaaataa ctagaaaaat actataatat atcagcttaa tacagaaaaa agttaaaaaa
    27061 tttgagaaaa ataaaaatga aaacgtttta tattgacata gagaaaaagt agtgatacca
    27121 tttaaatata gtttagtagc taaactatat ttaaattata ataactattt tagggggatg
    27181 ttatgaattt aaaacaatta agtgaaaaat acgaagaata tgtaattcaa atgagaagag
    27241 aatttcataa gtatccagaa ttatctttta aagaaataag aacaacccaa agaataaggg
    27301 aagaattaca aaaaataggg gtcccttttg tatctattga accaaatatc gtaatagcta
    27361 ctatacaagg caaaaatgaa ggtaagacaa ttgcaattag aggagatata gatgcgcttc
    27421 caatgcaaga agattcagat gttgaataca aatcagaata tgatggaata atgcattctt
    27481 gtggacatga tgctcatgga gctatgttac taggacttgc acatatgcta aatgatataa
    27541 gaaaagattt aaaaggtaga gtattattag tttttcaagc agctgaagaa gttggtggtg
    27601 gacacaagga gataatacag tactttaagg aaaatggagg accagataga ttaatagcta
    27661 ctcatgtttg gtccgatatt gaagctggta aaatttctgt tgaaccagga cctcgtatgg
    27721 ctggtgggtc tggttggaga atagacataa caggtagagg aggtcatggt tctagaccag
    27781 atcaaagcat agatcctata aagccagctt gtgatatagt tttaaaagta tcttctatac
    27841 cagttaatca tataagtgta ctagaacaat gtgttgtaca tgcatgtgca atacatggag
    27901 gaactacaat aggaaatgtt attccaaaca atgcagaggt aataggtgga tatagatatt
    27961 ttactgaaga atcaggcaaa aaagtgtttg acattataaa gcaaatgagt aatggtgttg
    28021 gacaagttta tggagtggat gtgaaggtta ctcatactgg aggcatagga cctgttatca
    28081 atgatgaaga agcagttaag atggctaaag aaatagtttc taatatagat ggattggagt
    28141 tagattctta tgagccaata tgtgcatcag attgttatgg tgaaatatta aaagagtatt
    28201 ctggctttta ttgttatcta ggggtaggta acaaagaaaa aggaataata tatgcacaac
    28261 accatcctaa gtacaatata gatgaagata cattaaagtt aggttgcgaa tttatggcta
    28321 aatatgcagt tgaattttta aataaaaata ataactaaaa taaatcgaat tttataaatg
    28381 ggggggatga aaatgcaagg tgcattaaag gaaaataaga aaaaaagtgg tggaggattt
    28441 ttaggatgga ttgaaaaagt tgggaataaa atgccacatc ctctagcatt atttacatat
    28501 attacattga tagtagtagc attatctgca atagcaagct ttttaggttt ttcagcaaca
    28561 agtcctgcta caggaaagtt aataaaagtt atgaacttaa taagtgcaaa aggtttagta
    28621 ctatttatgc aagagtttgt taagaacttc caaaacttcc ctgtgcttgg agtagtttta
    28681 gttatggcag ttgccacagg agtttgtgaa aagacaggat ttttttcaac tgccataaaa
    28741 atgagtttat caaaagttaa ggggaatgcg gttgtattta taatagcttt tataggagta
    28801 tttgctaatc aagctggtga tgctgctttt gtattagtac caactcttgc aggagcaata
    28861 ttttatggat taaatagaaa tccattagct ggtatattct gtggatttgc atcagttggt
    28921 ggtggatttg caacagctgt aattcctggg ggatgggacg ttacgctaac gccaataact
    28981 gtatcagctg ctcaaactat tcaacctgca tttgatatga cattattagc tagttattat
    29041 gcactatttg tatctgcgtt tatagtagct acagtatcaa caatagtaac ggttaaattt
    29101 atagaaccta aattaggtaa gtatactggt aaaccagaag gtatagatga taatcaaggt
    29161 tttgaggtca caaaagaaca agcaaaagca gcaaagttag caggttttac agttttagct
    29221 tatgtagcgt tattaattgc tttgtgtata ccagctaata gttttttaag aagtccagaa
    29281 ggttctttaa tatttggagc accacttatg tcttgcttac agttttttat agtaatacta
    29341 ttcttcttgc cagggattgt gtatggaatg agggttggta aaatcaagac tgtaaaagac
    29401 ttaaatgata tattatgtca atcaatggca gcaatggcac cgtttatcgt acttgcaata
    29461 gttataggtc aattcttaac gctattctca gtgtctaatt tagcacaggt actagctata
    29521 aaaggtggag cattactcaa ctcattgcca ctaccaccac aagctataat actgctattc
    29581 ttagtactag tagcgtttat aaatatattt gttataagcg gaagtacaaa atggatgata
    29641 tttggaccag tatttgttcc aatgttaatg caattaaaca tacatccagc atttactcag
    29701 tttgtatata gattaggaga ttctgtaacc aatcatttat caccattaaa tgcattcttt
    29761 ataatacttt tagcaacagt ccaaaaatac gataaaaatg caggtatggg aactatattc
    29821 tcagctatga taccttacac tataggttac tttgtagtac ttgcagtttt agtagtagtt
    29881 tggatgacaa taggtatacc agtaggaata ggtggacaag tttggttata aaacatattt
    29941 aataattttg ggaggaaaga aaatggaaac aactgaaata agatacaatt ttgatgaagt
    30001 aatagataga agtggaacaa actgtcttaa atatgatctt aagagtcaat ttatgccaga
    30061 atctccagaa gatgcactac cactatgggt agcagatatg gattttgcat gtgcccctga
    30121 gataattaat gcaatgcatg aaagaataga cagaaaaata tttggatata gctctcaaca
    30181 aactgatgat tattatgaag ctgtatgtgg atggtttaag agaagatttg attggaaaat
    30241 agaaaaagag aatatattct ttagcccagg ggttgtgcct gcgttaggat ttttcacaca
    30301 aatattaaca caaaagggtg atggtatcat aatagaaaag cctgtatact atccttttga
    30361 agataaaata actaataatg aaagaaaagt agttaatagt cctttaaagt ttgaagatgg
    30421 tcattattct atggattatg atggatttga agaattagct aaagatgaaa ataataaggt
    30481 gtttatatta tgtagtcctc ataatccagt tggtagagta tggaaaaaag aagagcttag
    30541 aaaaatagta gacatatgta agaaatatga tttgtggata atatctgatg aaatacattg
    30601 tgatattatt cgtaaaggtg aaaagcatat accattagaa gtagcatgtc ctgattataa
    30661 agatagaata ataacttgta cagctccaag taagagtttt aacttagctg gtatgcaatt
    30721 atcaaatata gtaatcaata ataaggaatt acaaaaaaaa tggatgcttg aaacagattc
    30781 taaattagct atattcctac ctaatccatt cgcaatagtt gctactaaag ttgcttataa
    30841 tgattgtgaa gattggatga atcaagtaaa tgagtatata gatggtaata ttaaatatgt
    30901 agaagatttt gttaatgagt atatgcctaa agtaaagata ataaaatctc aaggaactta
    30961 cttagtttgg ttagacttta gagggtatgg attagatgca aaacagcttg aatatgtaat
    31021 gcttaacaag gcgaaggtat tgctagatga aggatacata ttcggagaag aaggagcagg
    31081 atttgaaaga ataaatgttg cttcacctag aacaattata gaagagtgta tgaatagaat
    31141 aaaatgtgca tttgaaggat tataatagta atatctaaat aatatatttg tgtattttaa
    31201 aaaaagacta tgctaaaaaa atatttcaaa gcatagtctt ttaaagtttt atgatgagtt
    31261 taaaaaattt caaaacgtta ctattcactt atatgtttat attagaaata attccacaat
    31321 atactcattt tctaaagttg cacttttata caccttgctt caccaatatc atgtgtaacc
    31381 aaaatagtag acttattctc attcttaata atactataaa catcatcaca aactaataat
    31441 ctagtctgat aatcaagagc tgaaaaaggt tcatctaaaa gtagaatatc tggatttaca
    31501 gaaagtgttc taataagcgc aactctttgt ctcatacctc cagataattc ttttggatac
    31561 atacttctaa aatcccataa tccataagtc tttaaaaggc tttcaactct atctaaagat
    31621 tttttatctt ttttgccttg aatttccaat ccaatagtta tattatccat tatatttctc
    31681 cattcaagca aattatcttt ttgaaacata tatccaatat ttccagtaat ctttatatca
    31741 ccactagtcg gttttaaaag attagtaaga atatttaata ttgtagattt accacttcca
    31801 gaaggaccaa gcaaagttaa tatttctcct tctttcaagt taaaattgac atcctttaat
    31861 acttcaagct cgccttcctt agtgtagaag ttcatattta tatttttaac ttctactatg
    31921 ttgtcattca ttatgccacc ccctataact tttagctcgt atatattatg ttattaacaa
    31981 tatgacctat ttgtaccatt tttcataaat ataatataaa tattttgttt atttacgtat
    32041 tttcttagta acttgtacgt ataaattata gataaataaa ttataaggta ggggataaat
    32101 ttgagtaaca taataacgaa tttaatagag tcaatattta ctaatccaat aactatattg
    32161 tttttacttg caataactgt gtattctgtt tttaaaataa tagaaaataa cagagtatat
    32221 tcatttgtaa gttcaaaatt agacgaaatc aatagagact ataagacaag tgagttttat
    32281 aaaaaggtaa gggatgacta ctatacatat agtaaagaaa atccttatgc agacgtaaat
    32341 ataacttcat ttatagagga agttgtatct gatttaaagc ataataattt gccattgtta
    32401 gaaaaaatta gaagtataaa aaattcatct tcaataagta tattacttgg ggttttaggt
    32461 acgtttgttg gtctttctac aatgctttta tgtgttgata ctaaagacat tataaattca
    32521 cttccttcaa ctattagtag tatgcaaact gcatttacaa ctagtatatt tggagttgta
    32581 ttttctctaa ttataggtta ctttactaag ataaaagatt gtgaacatgt tttgatacaa
    32641 ataatgttaa aatctgaaaa tttactaaca tctgaaataa ctcattttaa gtcagaaaga
    32701 atggatttaa aagtagaaga ggtaaaaaat acaataaaac aaataagtaa gtctatagaa
    32761 gctattgaaa aatttgataa aatatctaaa gatttaaatg actttaatga tgaatttatc
    32821 agtggtatag aagctttaaa aagcctttta gaaggttctc aaagttctat taagacattt
    32881 gaccagagcg taagaaaatt agataaacag tttaatattt taaatataaa atttgtaaag
    32941 ctttttgata aatatgataa tcaagataat ataaataaag agattttatt tgatataaaa
    33001 gaatcttcaa aaaatatata caatgccact gaaagccaat tcaaaattag agattatata
    33061 aaaaatataa atgcaggatt tgctctatat gaaagaagtg ctcaagattt attaactaaa
    33121 ttaatgaccc atgaaaataa aatatctcaa aatcaaaaaa tccttttaga tgaaaagttt
    33181 accttagatg actcaataaa aaatctctca agtattattg aaaacttttc taatgaccta
    33241 caagttaaac tggatatgat gtttgaaaat tctttagata ttcaagataa gttagatgtt
    33301 atgtttaata actcttttat gaatgatgaa gttcctcttg atagtgaaga attatttaag
    33361 gatgatgtta ataatgtatt taatcctttt agtgaagaaa tttatgagat agaggataaa
    33421 gaaataaagg tcataggtga ggatgagtta aatgaataat aaatatagaa gaactgttaa
    33481 cagagaattt gaaaagagta gcttttggcc aacatttaca gatttattat ctactgtatt
    33541 gatggttgtg attcttatct tatttagctc agaaagtatt tcaggttctg ttgaacaaga
    33601 tttagctaag aatgtcaatg cttctgttga agaaactttt aaaaaaagtg gaatacctgt
    33661 gaaggtagat aaatctaatg ggcaagtaac ttttggtgaa aaaaccatgt ttgatgtaga
    33721 tagtgatgtt ttaaaaccag aggctaaaga aatgctaaaa atgtttgttc caaagtacat
    33781 agagactatt tataaagatt atggtgacta tatatccaaa atagttatag aaggtcatac
    33841 agatgatgtg ggaagttata tatacaactt agatttatcg caaagaagag catatagcgt
    33901 tgctaaattt atagtgggag atgaaatagg tgactataaa tacaaagata aagtgactaa
    33961 gcatattatt gcaataggaa ggtcaaaagc tgaactcatc aaaaatggtg acaatagcgt
    34021 gaatagagat gcatctagaa gagtagaact aaaatacgaa ataaatatta atcaaaataa
    34081 ataattaaat ttttataaaa aaaaagaagg cagttggtgt gagctttaag ccttctttaa
    34141 ggaaaaagtt tatttatttt tgttgatact taacatatta tagtttttag aagcagtttg
    34201 caatatatta aacgtaaatg gtcgtttaaa atgcataact ggatactact gatgtaaaat
    34261 atttcatttt atataatata aaaattatac agtgtcaatt ttctatatta ttgtactata
    34321 atctattatt taaaatatta tgtaaaaaaa tatcataaaa acgcatatca tgttataatt
    34381 actagagtat tatgaatatg gaggcgtagt ttgtgataga aataagtata aaaaataaaa
    34441 aaaattctaa aattaaaact ttgatacttt tattgatagt atctatatcg atttatttaa
    34501 ctggttgtac tacatcagat aatggaaata atcaatcaaa taataatgat tctttgtcta
    34561 gtagtatatc aagtgataag aatgtaaaaa ttcattttat tgacactgga aatagtgatg
    34621 caatattgat tcaagatggt aaaactttta cattgataga tgggggagat aatgatgatg
    34681 agggattaat ggtagattac ctaaacaatc aaggtgtaaa agatattaaa tatcttatag
    34741 ctacccattc tcatgcagac catttaggtg gacttgattc tgttgtcaaa aactttaata
    34801 tagaaaatgt ttttgtatcg aatggttcag cagaaacaaa gagttatagg gactttataa
    34861 atgctttagc aaataagggt ttatccccaa gtgtaccgct tgaaaataat aagttctatt
    34921 tagaagattc ttattttgaa gttctaaata caaatggggg agatactact aatgaacaat
    34981 ctctagtcct tgtatatact aatgggaatg ataaagtttt atttacaggt gatgctgaag
    35041 aaggtaccga aaaagaaata ctacctaagc ttgagaaagt agacctttta aaagtagctc
    35101 atcatggttc tcgtagtagt tcatctcaag agtttttaga taaagtaaat cctgaatatg
    35161 cggttctttt agtaggcaag ggtaattcat atggtcatcc acatcaggag acaatgaata
    35221 aattaaaaaa aatgggagta aaagtgcata gaagtgatga gtgttcagat ataatatttg
    35281 aatcaacagg tgatggagta tttacaagtt gtaaagatgg aagttataat aaaggcgtta
    35341 gagaagatgg aaactctgga aaatcaaaca gtaatacaag taaaaatgat tcttttaaaa
    35401 ataaacaaaa tacatccaat tcagaagaaa tagtgtattt tactccaaaa ggtaagagct
    35461 atcactctac aaaaaattgt agtgggcttt caagaagtaa aaaaatatta tcaggcacaa
    35521 ttgcagaaag taagaaaaat gacccatgtg atatatgtta tggaaaataa caaaaaaaca
    35581 accaatttat ctataaagct tctgaacttt aaatcattca aaaaataaaa taaatgcata
    35641 aaaaaataag ctataatcaa tagataacac attttatcta tacgaatagc ttattttttt
    35701 aagtattttt taatagctat ttaataactc taaatacacc agttacaata cctacaattt
    35761 caacttctga gtcattgagc ataattggtt ccataaaatc attttctggc tgaagtctta
    35821 ttaaatttcc ttctttaaaa aacctcttaa ctgtagcaga ttcaccattt ataagtgcaa
    35881 ctactatctg agaatttaag gctgtatttt ttttgtctac tacaacgtaa tcttcatcta
    35941 aaattcctgc attaatcata ctttcgcctt ttactcttaa tacaaaattg ttactgccct
    36001 ttactaaact ggcagggaat ggaatgtatt cctctatgtt ttgttgagct aaaatgggtt
    36061 ctccagctgt tatttgacct actaaaggaa gctctattat ttcttgatta gctccagaaa
    36121 catcatttac tttactacgt tctaaaactt caatagctct tggtttagta gggtcctttc
    36181 ttatgtatcc cagtttttca agtttattta gatgagagtg cacagttgaa gtagatctta
    36241 accctacagc agtacatatt tctcttacag caggtggata accttttaat atgatttgag
    36301 actttataaa ttccaatatc aagacttgct tttcagttag atctaaatac ataacatcac
    36361 tcatttccaa acatattttg tttttatttc catacacttt atatttttaa ttataacata
    36421 atccatttat atctgcaaac atttgttcct gatttttaat cgtcctcaat ccattcaaaa
    36481 ttcttgacta tatcacgttt tacatttttc ttatgagctg cataaagctg agtagttgtg
    36541 acattatcat ggtcaagtaa gttttgaaca tcatatatag aaaatcctgt ttggattaga
    36601 gaagttgcag ccgttgctct taatttatgg ggactatatc cattgtctct agtagtatca
    36661 agtggaatag atgtatattt ttttaccagt gttcttatag cctttgctgt aattctctta
    36721 ttttgaagag acaaaaataa agcatctttt tcttcatcat ttaatagttc atctcttgtt
    36781 ctttcgtttt gcaaataatc ttttattaca tgttcacaag tatgatttat aggcattaaa
    36841 acttctttcc cacgttttct atatatttta aattcacctc ttgaaaaatt aaaagaggag
    36901 atattgagtt ctctaagctc atttaatcta agcccgtatg taacaaataa tgctagtata
    36961 gctttgtcac gtaatttagt ttttctccaa tatacctttt ctttctctgt aagcccttca
    37021 cctgtttcta ctgattcaag catcttagca acttcatcta tctcaaggcg cttaatagca
    37081 tctggctgag gtttaggaag ttttattgga ttaaatccat cagttatatt attatctatc
    37141 tgagagtttc tgtataagaa tttaaataga gtagagatgg atgatttttt tcttgctaaa
    37201 gctctattgt tattttcaaa aatcaatgtg tttttttctg tatttttgta atatctactg
    37261 caataatcac ctaagaataa atttatatct cttgatttta ttgtattaaa atcatcttct
    37321 gtaatatctt ttacacaatc tgcatttgtt aattctttgg tttcaatcaa atatgaacaa
    37381 aaaaaattaa tatcttctaa ataagcaagt cgtgtagaaa ctgcaacaga accttttaaa
    37441 tatataaaat aatccttcat aaatacagga agtttatttt ccaaaagtag acatttttct
    37501 atgagttcat tttctttgat aacaatatta tcaggtttat ctgatttatt atgtactttt
    37561 ataattttct tatcattatt caaaattaaa cctcctaaaa ctaaaatata aatcttttat
    37621 attatttttt gatatttata ccaagtgagt ataaatattt aatttaatca ttttttacat
    37681 ttttaagaga ttagcagtac tttagatgaa attatcacta actattccct aaatccacat
    37741 ttaaagacta gttgaattta attactcttt ttttatttct caatatattt atagaaatat
    37801 tttaaaatat attaatattt ttatatgttt ctaacgaaac caaatattag taaaatatgt
    37861 atttatttaa ctaaagtttt taaatgggct gactaagctt aaaatatagg atattatgag
    37921 agttactatt gaaaaaataa accctattgc cataaagaaa cttataaata tgttatactt
    37981 aactattaaa ctggatatat tcaagttatc aaatccaaat aagtatgtaa ttgaacttat
    38041 tacaaaaata actataacta taaagctcag accatttaag ctatttttta aatcagcact
    38101 actaagtgac atatgtgtag atatagaata cattaaaaac ataaatataa aatacttcaa
    38161 tgaatataca ctaggtgtta acaacattat tcttataaaa ttggaaatat cacctaaaat
    38221 aatgtgtata aaaccattta tatttaagtt attaatcata cttacatata actttaaatc
    38281 tatattttga gtcactttca tataactatc tggcagtaat atcttaaaaa ttaaaataat
    38341 cattattgtt ccacctataa taggtgcaat tcctataaag aaatttccta tactttgata
    38401 aagattatct tttttatagc tatgacttac atatcctagt ataccatcat ttttactttc
    38461 tattggtctg aaaaacttaa ctgaatttat tttatgcatg aaaattaaac acattatcaa
    38521 atgactcaat tcatgaacaa atgttcctat agctccagtt acaataattc cagtttttcc
    38581 aaaagatgaa aatataaatt tattatttag attttctgta atgctaaaaa tcaatccaaa
    38641 tacaataaat attcctatga aacaaaaaat atttattaca cttattttta aaatttcgat
    38701 tatataaatc ataagttaag tcctcatgta aaagtattta actactctac ttcatatcca
    38761 ttacagctta aaattttaca agcattttct atatcttttt cttttactaa gatatagtct
    38821 gtatcatacg tagaaattgc aaatatgctt attttgttgt ctgctaacaa actacttaac
    38881 ttagataaaa ttcctacaag tgaaaagtct aaaggaccta gtatcttaag tattctccac
    38941 tccttttctg acttgacatc agaaggaata ttattattta aacatacaac acttaattca
    39001 tcatcagttc tagttataga gtaaaacttc tctgtatcta tccatgttgg tattttactg
    39061 tcattattta atctacatac tgcatactct tctaccaata attttaattt cataatgtat
    39121 atttcctcca atcttatttg tttacttaag attatacatt aaaagttaca taaaataaaa
    39181 catataaagt aaaaaaggtt cactatagtg tcctatttct atagccaacc tttaaaactt
    39241 aattaaattc taataaagag atatattatc taggttcaat tataagttta atggctgttt
    39301 tcttatcacc ttcgatttct atatcagtaa atgcgggaat gcaaactaaa tccattccac
    39361 taggtgcaac aaaacctctt gctattgcaa ttgattttat cgcttgattt agagctccag
    39421 ctcctatagc ttgtatttct gcaacgcctc gttctcttag tactccagcc aaggctccag
    39481 ctacagaatt aggattagat tttgatgaaa cttttagtac ctccatttca acatctcctt
    39541 gttaatttgt taaagtatcc attacctaaa gtactaaatc ataattgcca tttactaatt
    39601 acaatcatca tttaaagtat acttttataa aaatatactt ctataatcgt tttaagaaaa
    39661 cctttatttt ttttaaccat tttattatga aaaaactaca aatttcttta tattctataa
    39721 gcattttcca atatttctaa attttttata tctttgagct ataatttcct ctttatccat
    39781 atctttgtaa tgatttaatc tttctaaaat ataagctttt atttcttttg aaacagcttc
    39841 tacatctttt tgtgctcctc caagaggttc ttttataatc ttatctatta tttttaaatc
    39901 atataaatca ttacttgtaa gcttcataac atcacaagct tctttagctt tagatgaatc
    39961 tttaaataga atactagaaa gcccttctgg agaaattaca gaataaactg aatgttctaa
    40021 catacataca tcatttccta ctccgatacc taaagctcct ccactaccac cttcaccaat
    40081 tacaaaagtg attactggaa cagaaagttt actcatttca agtaagtttc ttgcaatagc
    40141 ttctccttgt cctctttctt ctgcttctag accacaaaaa gctcctgatg tatcaataaa
    40201 cgttattata ggtctattaa atttttcagc ttgtttcata agtcttaatg cttttctgta
    40261 tccttctgga tgaggcattc caaaatttct ttttatattt tcttttgtat ctcttccttt
    40321 ttggtgtcca actatagtaa cattaaactt tcctatctga ccaattcctc caaccataga
    40381 agggtcatct ttaaaaagcc tatctccatg aagttctaaa aaattagaac aaatatgttc
    40441 tatgtattcc aatgtcgtag gtctctttat atctctactt agtgttacct tttcatatgc
    40501 tgatagatgt gaaaaagcat cttccttaag cttttccaat ttctcattaa gtgaatttat
    40561 tttatcactt aaatctatat tatttgcctt agaaatagtt attaattgtt taatatcatt
    40621 ttctaagatt tttatttttt cactattatt ttcaatcaaa acagttcctc ctttatgccc
    40681 tatttcttgt gcatagcaag aatttgatat aatacttcct tcatttttct tctatctact
    40741 atcatgtcaa taaaaccttt ttcaagtaaa aactcagaag tttgaaatcc ttcaggaagt
    40801 ttttgattta ttgtttgctc tattactctt ggacctgcaa aacctatcaa cgtatttggc
    40861 tcagaaatta taatatcacc aagcatagca aaactagcag ttactcctcc agtagtaggg
    40921 tcagttagaa ctgatatata tggcaatgat ttttcttcaa gcttagaaag tgcttgagaa
    40981 gtctttgcca tctgcataag agataccata ccttcttgca ttctagctcc tcctgaagca
    41041 gaacaaataa ttataggtaa attattttca gcagcatact ctattgaata agttattttt
    41101 tccccaacaa tagaacccat acttcccatc ataaaatcag gattcattac acaaataact
    41161 gttttaattc catttattct tccataacct gtgacaacag cttctgactc ttttgttttt
    41221 tccttataag agtctacttt ttctttgtat ttaggaaaat ttagtggatt ttgaaattct
    41281 acatcagaat taaactccat aaaagttcct ttatcaatca ataaatttat tctttttctt
    41341 gctcttaagc cataatgtct tgaacatttt ggacatacaa atgaattttc ttctatgtcc
    41401 tttctaaata catgactatc acaacctttg caataggtcc aaaatttatc atctacacta
    41461 ttctttttaa agttgtcatc taaagaaatc gtaacatact tagattcttt tgatgataaa
    41521 aattttttta tcataatcta tttactcctt ataatgtagc aaattctttc ttcataaaga
    41581 catcttctat aaatttggta tgatgagtat cttctctaaa ctcctcactt gttacaagtg
    41641 ccttttgaaa ttctacattt gtattaatac cttctacaat aatttcgtct agagctctat
    41701 atattctact tatacattct tctctagttt cagcccaaca tattaactta cctatcatag
    41761 aatcatataa aggtggtata gtatatcctg catatacaaa agtatcaaat ctaacaccaa
    41821 aacctccagg taaatttaat gattctatct tacctggtga tggagcaaaa ttctttgatg
    41881 aatcttctgc atttattcta cattcaatag catgacctct aaaagtaata tcttcttgtt
    41941 taaaaggaat tttatcccca ttagctatag atatttgaag ttttataagg tcaagatttg
    42001 ttaccatctc tgtaactgga tgttcaactt gtattcttgt attcatctct ataaaataaa
    42061 agtttttatc tttgtcaact ataaactcaa tagtacctgc accgatataa cctactcctt
    42121 ttactatatc tactgcaatt ttatgaagtt tttgtctttc ttcatctgaa aggtatggac
    42181 ttaaagattc ttctattact ttttgatttc gcctttgcat agaacaatct ctatcaccta
    42241 aatgtattgc atttgaatgt ttatctccaa atacttgtac ttctatatgt ctaggatttt
    42301 ctataaactt ttccatatat aaatcactat tagaaaatgc tgctagagct tctgaacttg
    42361 ccatatcaaa atttgaaaaa agttcttctt cttttctaac gattctcata ccttttccac
    42421 cgcctccact tgaggctttt atcataacag gatatccaat ttctcttgca acttctaaag
    42481 cttcttcctt agttttcaaa acagattctg aaccaggaac aacagggata ttcaattcca
    42541 tcatagtttc tcttgctcta gatttatctc ccatcaaaat catttgttct cttgttggac
    42601 ctataaaaat aatattatta tcttcacatt gctttgcaaa ttcaggattc tctgataaaa
    42661 atccaaagcc tggatgaata gcatcacact ttaatttaag agcaagatag attatatttt
    42721 ctatattatt ataactctta cttatattat ttggtcctat acaaatagat tcatcagcta
    42781 tatatctatg aaaacaatct ttatctattt cagaatagat agcaacagtt tttataccta
    42841 gttctttaca tgttctgatg attctaactg ctatatcgcc tctatttgca actagtattt
    42901 tttttatcaa cttaaatacc tcctactaca atggttttat cttaaataaa ggttgattat
    42961 attctactag ttcttcatta ctaactaata cttcaattat ttcaccttta atttcacttg
    43021 ttatctcatt cataagcttc attgcttcta atatacataa agtgtcgcct tcttcaacta
    43081 catcgccaac tttaacaaag ctatctgcat ctggacttgg agaatcatag aatgttccca
    43141 tcaaaggagc tactactact gatagattct cattagatgt gacaggtgta tcgtttacaa
    43201 ctggcttttc taaagaaaga tccactactg attcttgttg tacacttaaa acaggtgaac
    43261 ttgtagattg agctttttta gatacttcta atcttaaatc gctactttca agttttacat
    43321 attctaagtt agttgagtct atggccttta ataattcctt aatttcattg atgttcattt
    43381 tgttaccccc ttgtattatt acctggtgct aatattatat cacaaaaaac aaatttataa
    43441 aagaaaaagt gctgactaga gaatcaacac atcaatatat cttttaattt taaattaaca
    43501 accagtaact tatatttgtt ttaattttcc attattaata taaattataa gtataaaatg
    43561 aataaaattc aatatttttt gcaaaataca agagaataca aattaatacc tcgggaattt
    43621 ttaagacaaa taccaatatt atgcaattta gacttcgctt tctttcaaat tagtatcatt
    43681 ttctttattt ttacatagga tgtactttaa tttagctatc aaaacattgc tatataggtt
    43741 aaaagttatt agaattgcag gaattataaa gtaaactcta gcacctataa aaccaaaaac
    43801 tactgtaata agtattaatc ttttatttaa agtaaaaaaa ggtatattaa aaatactttt
    43861 gtcggatgtt tctggagtat aagaatatat aactccaaaa atcaaagtaa gcatacaaag
    43921 tggaagtagt gtataacttg aaattattcc caaaaatcct atactttcaa aatatttgct
    43981 agcactattt gtataaacaa acatgtatcc atttaaatat gcgcatatac atgatataat
    44041 gccaaaagtt ccccctaagg attgagtgta ccaattaaaa aatttagatt ccatatacct
    44101 cacctcctaa aactgtatat ataatgatat gcatttaaat agtaaaatat atctttatat
    44161 gtttctgaat aaaattttgt taatttcatt aatttatgtt taagaaattt gaagtatagt
    44221 gtagtatata ttaatgtaga tgaagtttta tagtacttat ttcatagtgc ttaatcaagt
    44281 tatcttatta tggattcaaa agttgtttgt agggttttat attttgttga gctgaaaaat
    44341 ttattataaa tgaagggatg ttttcgcttt ggtagataca ttagaatttg gtcttaaaat
    44401 tttatttttt atattatcaa taatttggat gggtaaaata atgattttaa gaactgataa
    44461 gcaaatagta atcaatcctt tgcttattgg tatatctgca gtccttgtga tgttgcatac
    44521 ctcacagagt aacattgaat tttttggatt agatgtccaa tatataagaa tagttttgta
    44581 tataatatat tcactgataa ttttaatagg aatatgggct actaacagaa gaaatggaat
    44641 tttttagata atctatttct ataaaattta aaggttgcta gtaacaaatc actaatatta
    44701 gcgttctgtt actaacaacc tttattttga ttatacactt aaattgaaaa tagaatgatt
    44761 gaataagttg acagattatt ttacattgac agtaattaga acttcttgag atgtatttaa
    44821 atcatttttg tcgcttagta taacttttac cactgcttga cctgttttat tacctttaat
    44881 tatcatatct tcacatgaaa gtacactctt atcacttaca gatacaataa aatttaaatc
    44941 ttttggaagg ttatcagtaa cttcccagta tttataataa ctatcaattt tcttcgtaat
    45001 tatttttctc aaatcaatac tttcaccttt tgctatatca acattatgat atttagagtc
    45061 cagtttatac tgattatctt ttgtatcaat aaaatttaaa tcgcaattta catccacacc
    45121 attatgagaa agagaattta ctacatcgtc atcaatcaaa taattattgg caagatttat
    45181 tgaatccata tcttttagac ttaaagcttc cttaggaacc tcttttatat tattattcca
    45241 aaaaataaaa ttgtctacat tttcaagata tgatatacct tttaaatttg aaatactctc
    45301 accagttgca taaaattctc catctaaagc ctttatattg cttatagtca tctcatctgg
    45361 atttatatat ctttttacaa ctgctcttaa atttgcatca ggaaaaatat ctttaagttg
    45421 attttcgctc aaaaccttat catttgaatt tattggactt aaagctgctg cagaaataat
    45481 aaatggtatt aaattagcta aattcatagt accctcccac ataaattttt tattataata
    45541 atttaatttc tatgagaggg ttctgtttcc ttgttatata tacctacttt cgtacacttt
    45601 attaatataa attaaaataa atttctacta ttaaacttat aaacatatta ctagttacgt
    45661 tttttagctt cacatctaaa tattcgcata ccttgtgaca taaatttgtc ttcatactct
    45721 gttgtaacat tattttcata ctcactattt cctaaatcaa gagaaatatt ctttaatagc
    45781 caattatttg cagcaatttc atttaaacta aactcgaata atttttcatt atctgtttta
    45841 aagtgaattt cgccatcatc ttccaaaacc ctattgtaca tttctaaaaa tccagaatga
    45901 gtgagtcttc ttttactcca tctattttta ggccatgggt cacagaaatt tatataaatt
    45961 ctcgataatt ctttagcttc aaagtaatcc aaaatattgc ttacatctcc ccataaaaat
    46021 agtatattat tcaaattaga agcatctgct ttttcaacag cctttaaaag aacttcttcc
    46081 ttaagttcca tggcaatata atttatgtca gggttctgct tagctaaagt tgttataaac
    46141 ttaccttttc cagtcccaaa ttcaacatgt attggattat catttctaaa ctttaaattc
    46201 cacttgcctt ttaatttgtc tatatcgtct cttaaaacat attttgtata acttaaaagc
    46261 ttttcatctg cacctttttt tcgtcttctt ctcacaataa ttctccttac atataaaaaa
    46321 ttagtaaaat acatttttat tatacattat ctcaccaaaa aataaaaaga actctcttaa
    46381 aatagaaatt tatttctata aagagagttc taaacttact aaaaacttaa tcttagtggc
    46441 accctgaaca accagagcat cctcctccac cttgatcttt catattttca ggaataactc
    46501 taaatccaaa tcctgtatct tctattatta tatctccata ctgactatat tcatcagagc
    46561 tcattacaaa ttgtaattct ccaacttcat aagttaagtc atcttctttt ttctcatcta
    46621 aagctaatcc aaaagaagga cctccacaac caacacctgc aaagtatact cttatattat
    46681 taggtttatc ttgattgtct tttaagatac tttttaaagt atcaatagct gtttctggta
    46741 aagtaatttt catcaaatca ttccctttca aatattttat taaaacaata tctattatat
    46801 acccatacaa ggtacataat caattagttt ttgcatattt tactaaaact tctacctaat
    46861 attacctaag gctttaaaat attttatata atattttatt accttaaata aataccctat
    46921 cataaactta gtaaacaaat aaaattatta ttctaaaaaa tataataatt ttatttgttg
    46981 ttttaatatt ataacacatt tgataatgtc caattcatat atgcaaaatt tatatacttt
    47041 aaaatatcta agaaattatt caataaaaaa atactatttt ttaaaaatta tcattattga
    47101 taaagctcta ctatttatat tttttagtgt attcatgtat aataagtaaa agcacaacgg
    47161 tatatactgt tgtgcttttt tgtaattaat aaacaatatt ttggtctata acaatgaaaa
    47221 atggctactt tccataattg atttcatctg acataagcaa aaagggtgtc cagctgggtc
    47281 aatcataact ctccagtcat cagtaaattg ctcctctgcg attgtagctc cacaatgaat
    47341 tgcatattga actgcttctt ctaaatcatt aacagcgaaa tccatatgag ccatttgctg
    47401 ttgagattca ggtttttctg gttctattat gccccaagcc tttgtttttt gcaatataaa
    47461 gaaaaaatta tatattttaa tattttataa ttgttgaaat tgtgtaataa attcaactgg
    47521 atacatagtg cgttttgaaa tttcttctaa agctaaacct tgttttaaaa acctctttat
    47581 gacgctttcc atactttctg aaatttctat aatattttta tcaaaatcat aaaacctaaa
    47641 agttctttga ccccatgggt attcttttat ataatgcaaa aattcaatat ttcctattct
    47701 atttatctta ctttcccatt gtttgatgtc attaacctca aaatacaact gaaagttatt
    47761 tgattgttga tatattggta aatcatatcc aattatagct ttataattac tttgtaatcc
    47821 aaatccattt tcaaatgata catgttctcc taaatctaat gtgatttttt gctccataac
    47881 atcttcataa aacttttttg atttatttat gtctttgaca attagcaata ctcctccaaa
    47941 tttcatctta tcactatcct ttctttgtta taagtattat aacttaaaat tttgcaattt
    48001 cactgtaaaa atcagacata ttagctcggt atttttgagg agttattcca cagacaattt
    48061 taaaatcttt aataaaatgt ggtatatcat agaatcctaa ttcattacat atagacatca
    48121 atgaagtttt attattgttt agaagtttta tagatttatt aatacgtacc aaacgagaaa
    48181 atgacttcat actcaaccct aggtactgat taaagagtct gtttaaatgc ctagaactat
    48241 aaaatacttt tttagaaatt tcttgtgaag atatatttcc agagttttga ataatcaact
    48301 gaattgccaa aataaactca tatgagtatt caattttaat attagaaatc aataattctt
    48361 ccaactttaa aatcaattta tctatagata aagattcatt aaatattttt ttaatttcta
    48421 aatctaatga agtattaatt atagaaaatg gaacaacttt atcaataagt tcactttgct
    48481 gtatacctat aagcgggaaa aaaccagcag gttgaaattc tataattagt ataacatcac
    48541 atctattagc aatatttcct actgtttttg gtttagtagt tggaccaaat aatagactat
    48601 gtaaccctgt ggcatcataa aaaaacacca aagttacact tccatgagga ataatcgtgt
    48661 aattatcaga aattattgtt tgatttggaa acgatatagt aaaattcgat atccaatttc
    48721 ttaattgtat acaaggcaag agataaacaa aattgtcttc acaaactata agtgacctat
    48781 ttttatttat aaaatgaata ctttcttttt ttaacatata ttatatcctg tcctatcgtg
    48841 aatatttatt aaagtaagaa gaatccatat tatctctata tatcattaac tgcttttaat
    48901 aatagagata gtatgaatac tcattagata tttaataaac aaataaaatt aaaataatca
    48961 ataaaaaata tagtactttt atctgttatt ttaatattat agcacactta tagtatttaa
    49021 cttatatcca ctttacatat gtctaattta tataattaaa aatgcttatc tcaaatacaa
    49081 taattagtcc ttatacaatt aaaccatctg aaactataat agtacgacta ctacttttgg
    49141 ctgcttctgg tgagtgagtt accataatta tagtttgtcc attgtctctg tttattttat
    49201 tcagtaaatc tattatttct atccctgttt tactatctaa atttccagta ggctcatcag
    49261 caaataaaat ctctggtttt ccaattaaag ctcgagctat agcaacacgt tgttgctgac
    49321 caccagataa ctctcgtggt gtatgtttac gtctatcagt taaaccaact atatctaaga
    49381 tttcatctaa ttgattttta taatctttta aatttttacc atctaataac aaaggaagca
    49441 ttatattttc ctccacattt aaatttggta ttaagttata aaattgaaat acgaatccta
    49501 tatttctacg acgtattatg ctcattttct catcattaaa atgtgatata tcagctccat
    49561 tcatatacac ttttccgctc gttggagtat ctaaaccacc taaaatatat aaaagagtac
    49621 ttttgccaga accagattga cccatgatag aaacaaattc acctttcatt acttgtaaag
    49681 atacatcttt taacactcga gttgttgtat ttccaatttt atattctttg ataatatttt
    49741 ttgcttctac agctaaacta ttatgtgtaa ttttcatatt aacctccata attattcaaa
    49801 cttaatttct tctatcagtt tcattttctt cccttttata ataggcacta tcgaacctat
    49861 taaagttact ataattccca ataacccaac aataataaat gttttaaaat ctaaatctgg
    49921 tttcattgaa atttttggtc ctgcaactat aaagatagtt tgaatctcaa gtatagatat
    49981 cacaatacca ataacagctc caagtaaacc tgaagtaaac ccttcaatca atgttacttt
    50041 tatattttgt ttatcactta gtcctataga tttatacata gctatagaac gtcttttttg
    50101 aatataatta atcagtagat tattaataat acctactgta gcaagaagaa aaatgaaata
    50161 ggtcatctta ttcataggag acaaaaaact acttatagta tttaaagaat cattattaaa
    50221 ttcttcaact gtacgactcc aattatatgt atctccaaat aaatatctta tctgaatcat
    50281 aacagcatct ggattgactg ctgtatatac taaaaaacca taattagttt tatcaaaatc
    50341 attaactgca taatgtgatg gtataacagc ttctacatca tttgcacggg atttaaaact
    50401 acctactatt ttataagaaa aatcatactt atcattagat agagttattg tatctcctat
    50461 agataagcct acttttttta gagtatcttc attcaaaata acagaacgtt tatcattaaa
    50521 agcttctatt acttgttttt ttatctcaaa atttgtataa ttgattccaa acatagagtt
    50581 atatagtttt atattatctg taccctctag tcttgataat gttacaccat taccagaaat
    50641 ctcattattc ataacataaa gaggtaatat ttttttaatt ccatccatat gtctaacatc
    50701 ttcaataaac tcttcattca tctttccatc tgcaaaacct tgtaattctg cgtcacgaaa
    50761 cacatctgtt atataagttt tgacaaagtt accaacaaca cttattgcaa taactgcaga
    50821 aatacttata aatagtaaag tgatattctg tattatattt ttgttatttt tcatatttct
    50881 agcagctaat ttaccctcat tccctaaaat atttttataa acaaactcaa aaactataga
    50941 catgatatca gtaataagag gaatcaacac aatagtagct acaattaatc ccagtaatga
    51001 aaatccacca gctagataca atgtattttc aggggatatt cttggaagta aaatagataa
    51061 aataaacatt atacttccta taaaaagtat agaacgattt gaaacattct tttcttctac
    51121 tgttcctagt acaatatttt ttatcggcaa atggctagct tttttaacag gtatatatgc
    51181 actaaatgaa gaaacgatta ttgctactat aacagatata atcactccaa tgggtgatat
    51241 tactactgga attgatattc cttgttcgag agaatttcct aacccatgaa gcattaaatt
    51301 taaaacaact acaccaatag gaatagcaat taatcctcct atacttccgt ataatatact
    51361 ttcaagcatc aatatacgag ttacagtttt ttcattggca ccaatacttc taaatgttcc
    51421 aataaaagga agacgttcta atgtaataac cttataactg ctgtatatta taaatatact
    51481 aagggttaat gcaaaaaaac ttattaaaaa gaaaggcatt gtcttttgtc tagcatctga
    51541 aattatctta gtttcattta tagtatttga taccatatat ttttcagtag aaagttcttc
    51601 ggataattta tttactagat tttctgtaat ttcttcttct gactctataa gaactcttgt
    51661 atatccactg cctttattta taatttttga tagagtctct ttgggtagca gtgcatttac
    51721 acctcttgtg ttcctcaaaa atactgtatc ataagatgca atatcactaa cttgaaaagt
    51781 ataggacttt ccataaatct gtaaagtaat agaatcacct ttttttattt tatattttga
    51841 tgtaaagcga tttggaagaa taattttatc accagaaaaa tcagtaatac tatcgccatt
    51901 ttctaatcgt ggcttgttga ttttatttag ttgacttaag tctgctgata taagactaaa
    51961 ttcttcatag tatccccctt tattataaat agcagagctt tccaatacac caacctttga
    52021 ttttatagta tttaaatcag gtatgtcttc taaattggtt aatatatctg gatttttact
    52081 ttggacagat atagtcgctg taccatacat accttttgcc atttttcttt gtgcactttc
    52141 ataagataat ccaattgaga atgaaacaaa aagtaaaact gttgataaaa ctatggacaa
    52201 taacataact gctgttctaa tttttcgttc tttaatattt gtgaaaatat actttaatat
    52261 aattttcaaa cttacacctt cttcccttat ctaagatatt tcaatctaat atttttatac
    52321 tttaatctaa attaaatctc taatagactc ctccatattt ttatcattat atttataata
    52381 tttttaatca aatcacccc
//
LOCUS       DAEQCW010000013        51564 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.013, whole genome shotgun sequence.
ACCESSION   DAEQCW010000013 DAEQCW010000000
VERSION     DAEQCW010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 51564)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 51564)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..51564
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.013"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            120..749
                     /locus_tag="KRO40_000844"
     CDS             120..749
                     /locus_tag="KRO40_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091676.1"
                     /translation="MNKYLLINPVAERMYGEKFHLIKANLIKKGYIIAECEPQLEYVK
                     KQYKEYTKKTKNTMLDCRCPESISLLKRNNLINDFEVPMIEPILVRTCRVLYDKYIKS
                     KDDMLVVTCPCTQLRDFASEKFKDKGNAMFYTWKEFAEQEGVKSLGKIDESPIPLGYF
                     KDTFEKVLEVSSEDEILSEIQKIRNGFEDKYDIVEMFYCKDGCNNGDGL"
     gene            750..1532
                     /locus_tag="KRO40_000845"
     CDS             750..1532
                     /locus_tag="KRO40_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091677.1"
                     /translation="MVNKFNNKFLRLVKSVLIFFIILLLWKITNYLGIWSDYILPSPE
                     KVYSTFLNMISDGSIFINVYASMKRVLIGFAISTAIGVPLGIFFGIYSGVYEYFKSLI
                     NFLRNTPPLALIPMLILWFGIGEESKIIIIVLASFFPIFTSTLKGIKNCDSKLIEVGR
                     VFEFSKLQIIFKIIIPNAILDIAVGLKLALGYSFRAIIGAELVAASSGLGYLISDGKE
                     MSRTDVVIVGIIVIGLLGIITDYIFSIIVKKVSKGKMVEAYE"
     gene            1525..2403
                     /locus_tag="KRO40_000846"
     CDS             1525..2403
                     /locus_tag="KRO40_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091678.1"
                     /translation="MNNLVCDSGYIIRNLYKSYKVDNEEHVVLSDISLNIDRNHITVI
                     LGESGCGKTTLLRAIASLEGINSGEIRFINDNKEYRPNVGFVFQESRLMPWLNVSENI
                     AFHNQRKNTILNKVLRKFKHNKRISSKIINDNFRSLETNDNLNKSNKYNRKSNIDVEK
                     YLKMMNLQKFKNSYPNELSGGMAQRVSIARALSFNPDMLLMDEPFSALDYFTRIDMQN
                     EVIRIHKSTNKGVIFVTHDIDEALKIGKKIVVFTDERKIKEFNIEDGYNRDLTSDYYI
                     KLKKDILMTMKSNKGI"
     gene            2436..3395
                     /locus_tag="KRO40_000847"
     CDS             2436..3395
                     /locus_tag="KRO40_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2091679.1"
                     /translation="MKLKKLLIGITILTLATASLAGCAKKNNGEKLSEINLTYVKSPL
                     NVPSIIQKQDDLFGKEFKKDNIKVNFHEITTGPEQTQALAAGEIDFLHALGGTSALIA
                     ASNGVELKILNTYSRSPKGFMILTNNNSIKSAADLVGKKVAGPKGTILHQVLISALDK
                     EGLSMDDVEFVNMGIPEASAALSDGSVDAALIAGPAALKAMKSGSKLVANGEGLVDGI
                     IVTAVSTDFAEKHPEIVERFMKVEKETLEYVNNNFDEAMEKVAKEVDLSLEETKELYA
                     WYDFSLDITDKDISSLEDTQDFLIKNKLQEKKVNIKELIYNAK"
     gene            3709..4401
                     /locus_tag="KRO40_000848"
     CDS             3709..4401
                     /locus_tag="KRO40_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091680.1"
                     /translation="MSYKVYIVEDDISISTLLKDYIEKYGFEVIVEENFDDIMITFES
                     FKPHLVLLDVNLPKFDGFYWCRCIRQQSNLPIIFISARDGNVDQIRALESGADDYITK
                     PFYYDVVMAKIKSHIRRVYGEYSPKIDERIVELDGLKFYPERLELELNGENLIITKKE
                     GILIECLIKRYPKVVSRDYLLEKIWDDIEFVEENTLNVNVSRIRKRFEELGIDNAVQT
                     VRGLGYKLNKNW"
     gene            4411..5415
                     /locus_tag="KRO40_000849"
     CDS             4411..5415
                     /locus_tag="KRO40_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091681.1"
                     /translation="MKLFLKDYKGYIFIYYIGIVMTIIYCNLMKFISFGESLYILLFS
                     SFILLCFLIYKYYKNREVYNLFEKGVHSLEESFLYLGSSFLGRNISVILKQQHKLYQS
                     MIQEHKKIHSEHLTFINQWIHQMKTPISVISLQLQDYEGEEVTENIRKEIDRLNKGLD
                     MAMHFARADNFQKDFIVEKAKLNEIVSSIVNEEKRLFIKSGMIPKIQVDKFTYVYTDV
                     KWMKFIIGQLITNGVKYSKDYSNYLTIKSEENNKYVILSIIDEGIGIVSKDLKRVFDP
                     FFTGENGRKFGESTGMGLYLVKKVCDDLGHKVSIKSEVGKGTEVSIYFNKDVNSLIKV
                     "
     gene            5663..6514
                     /locus_tag="KRO40_000850"
     CDS             5663..6514
                     /locus_tag="KRO40_000850"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBH2091682.1"
                     /translation="MSLDVIFILKSVIIAIVEGLTEFIPVSSTGHMILVGNLIDFKGQ
                     FAEMFEVVIQLGAILAVVVLYWKKIKDSVIEFFKFIFTGGKEGKIGFRFGMNVIIGCI
                     PFAIIGVLFYDNIKSLFNLQSVIIGFIVGGILLLVVETLFRKKNHSTDNIDKITPIQA
                     LKVGTLQVLSAWPGMSRSASTIMGGWIAGLNSPTAAEFSFFLAVPAMVASSGKDLFEF
                     DYSIMTPTLWIALVVGFIVAFIVSIIVMEKFVNFLKKKPMRVFAVYRIIMGVVLAVLA
                     FTNIISV"
     gene            6618..7364
                     /locus_tag="KRO40_000851"
     CDS             6618..7364
                     /locus_tag="KRO40_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001637630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091683.1"
                     /translation="MKILTVNNLSKVYGKKIIFNALNDINFSIEDGEFVGIMGPSGSG
                     KTTLLNMISTIDKPTTGTMELKGKNPLLLRGEELALFRRRELGFVFQDFNLLDTLTIG
                     ENIVLPLTLDKVSVKEQDERLNEVSTILGIKDLLGKRTFEVSGGQAQRTAIARALINN
                     PSILLADEPTGNLDSKSSKVVMELFQKINKENKVTTMMVTHDPLAASYCSRILFIKDG
                     SIYNEIYKGSSREQFYQEIMDVLTLLGGDN"
     gene            7364..9280
                     /locus_tag="KRO40_000852"
     CDS             7364..9280
                     /locus_tag="KRO40_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091684.1"
                     /translation="MNIKQFAINNISRNIKAYLGYLASIVISSSLLFSFIMFTSHPDL
                     DVSQFPDYLKEGLKMSKIIAYLFLFFFVFYSVSVFLKSRYKEFGILYITGISKRQVMK
                     LIFIENMIINIVSSVIGIIIGLIFAKIFLVVMSTFLELSPLKFYIPFNAILSTLIYFM
                     ILAVLTSIFTSFIVKENQVLKLLKGTKTPKPEPKTSLMLAILSICLFIIAYYNAITST
                     DQYTTYLRLVPVTSLTIVATYLFFSQFSVFFMKKLKLNKRFYRKNTNMLWISNLIYKV
                     KDNARIFFLITITSAVAFTAIGTVYSFWKDVERQINLIYPNTIYYSTMTLHNDPKKPD
                     SKEKDKERMMFIENNLKKENVDYTRTNGEFKTVFPKKSDFNVRIMKESKYLEITETIG
                     VKPISFEDNECISLLSSSLPGNKNIKENIIVGNRGLKVAKQVEECVMPAYYKNMYVVK
                     DNFYDSIESKFIVDRFTAFEVEDSSKTIEICRKFENKFNNESGMQPYLFFSKELMIGT
                     GKLMYSTFIFLAIFIGLIFFVTTSSFLYNKFYMDCQVDKKKYEQLNKLGMTYNEIKKA
                     STIEIGIVFLFPYVVAVIHSIFALTALKNSFDIEVASSAVLVMGSLFLVQIVYFLIVR
                     NNYLKEIRLNLVNF"
     gene            9559..10476
                     /locus_tag="KRO40_000853"
     CDS             9559..10476
                     /locus_tag="KRO40_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH2091685.1"
                     /translation="MMILIQSRGKMKCKELSEELEVSERQIKSYKMYLEQAGIFINST
                     PGIYGGYEIDKCNSISLIKLLDSEVSILDMINSQLEYNNDIYKNEFNNIVEKIKAVLN
                     TGEKSDTYMDYFTVQAQCNCDYESEKNKCNEIIRAYTTKHKFWIEYYSLNSGNSERIV
                     HPYGLFNYKSDTYMVAFCEKRFKFIDFKLCRIKDYKVLEEKYNVDKSFSWDEYSKNSI
                     GIYKGEEISVVIKISHPFSTIIKEKVWVNNQQIIEYDDKSIMFKAKMRGYEEIKSWIL
                     SMGAYVEVVEPDRLRNDILLEIEKMKKIY"
     gene            10554..11291
                     /gene="cas6"
                     /locus_tag="KRO40_000854"
     CDS             10554..11291
                     /gene="cas6"
                     /locus_tag="KRO40_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBH2091686.1"
                     /translation="MKMKIEFSTGCIPISYNSLFMSIIKEAIRKSNEDYYKNMYYYKE
                     KNNKKTKNFTFSVYIKKYSIEGDNFIIEDKVILNISTPDLELGFHIYNGLMTSKKCLY
                     KDYELTRIRIDLSREKKVTEERVLFNALSPICVKSKEGKFLEITDDRYIEELNYITNE
                     VVKNYRGNGLKRKLEFENIGLKKVVVKESLREFKKITGKEYQYINGYKGKFILKGDID
                     DLNLIYNLGIGFRRAQGFGDVDILEWR"
     gene            11297..13174
                     /gene="cas8a1"
                     /locus_tag="KRO40_000855"
     CDS             11297..13174
                     /gene="cas8a1"
                     /locus_tag="KRO40_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein Cas8b1/Cst1"
                     /protein_id="HBH2091687.1"
                     /translation="MKLRVYRGDWFFNMGIVGFLNIIKKADKQAEIFIMEDYIEFDSL
                     FLENFHEYYFNYFMDEYDVSKRIKKNIDYSINFIKSKPDRIKDGIKKIKDSVKQQNDK
                     IKKFDEEKFNLIKEKLDSMSKIKSYDEFDSLEALVDETIDIFKIKSINDRLTANLYKY
                     VVQDNYFGQVSFFNVAKAKLDLDGLKQVMFNDYLRQIIYFGELEDLLEENDYDKLKNY
                     LNDRLNSIAKDINEKKVSKSSINTIEKIMKEINKNFIKKNKSIEDIKKYMDSLEVCEM
                     CGLYKGILDEYSESNFAPLGVSTNNARNMFWNQAYVPSICDICKLILFCTPAGATYTR
                     KNYLINEENEFYLFVNMDTCINELFERNNSLKAQKSEYSDSKEENPFNQLIKSIVEEN
                     TLKSEWQLRNILFVEFKASIDSKKCKINYFNIPTYLAKFFTDKYANKKIQSIYDYKLK
                     SNVLDLLLKNRDLKHLINNILRNKVKNDMESNNKSNISGIDCFRVVQLRALINSYKKG
                     VYKMDSKNLEKNDEKLRIIYYLGCDIHDYFVNKNSKNKIGGVSYKLLNSVKVGNKSDF
                     MDTIIRVFMSAEKQMPAFILDIEIEKDLDFESIGHAFISGLISGKYEGKDKLPNEKEE
                     K"
     gene            13176..14090
                     /gene="cas7i"
                     /locus_tag="KRO40_000856"
     CDS             13176..14090
                     /gene="cas7i"
                     /locus_tag="KRO40_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein
                     Cas7/Cst2/DevR"
                     /protein_id="HBH2091688.1"
                     /translation="MKRGLTFTVIAQAQSLNYGEGIGNISELKKLSRDDGNIYTFASR
                     QCLRYDIVRLAAELFNWNLQVVDKEKGTIQFKDNISIRESEEMDLFGYMKTNKKDEKD
                     KKGGSLTREATVRLSNAISLEPYRSDMDFLNNKGFADRIGEHPNLANIEQHLSYYTYT
                     VTIDLSKIGKDGEIELDNKEKCRRVVEFLEIIKVLNRNIRGRQENLSPLFVVGGVYEI
                     ANPFFLGRIKLKGDKNGFKINKQAIEEVIQGTFLGKDLKEFTYVGMVDGVFINKEEFK
                     GLFEDNFFSVDKFFGQLVKEVKEYYGVN"
     gene            14092..14793
                     /gene="cas5b"
                     /locus_tag="KRO40_000857"
     CDS             14092..14793
                     /gene="cas5b"
                     /locus_tag="KRO40_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein Cas5"
                     /protein_id="HBH2091689.1"
                     /translation="MKVLKLDLFQETACYKKPFAMKITETYPLPPYSTINGLIHKILN
                     ATEYIPFNISVQGTYESIFNNYQTTYFYKKDSITSMPMNSHMLLNVNLIIHIGGDFDL
                     LEEIYDSLLNYDEHLSLGRKEDLVRINDIRFVEVNKFEVDEDIQLDDYENYKLSECNI
                     RMPIYIPKTSLQDTDIDGISYRLNNYYDNNAVEDKKRVWNKVDSYYVEDGNTISIGDI
                     LLDNEGDLLYFNNIN"
     gene            14804..17125
                     /locus_tag="KRO40_000858"
     CDS             14804..17125
                     /locus_tag="KRO40_000858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="HBH2091690.1"
                     /translation="MLYAKSNPVETLREHTDELLKQMNVLRESYGKNINSLDFLEEEI
                     FWQLLDLVIEFHDIGKAFSPFQELIKSRMDTKINEPKIVTHLENNVGHNYLSPAFIDY
                     SYIDRKKNKELRAVLNQVIVYHHERDIFIDKDFKNLIQKILDEDLINKVYELQHEFKV
                     RYPIKTERLSKVYLQSVEKRIDKNHKYYNLYIMLKGILHRLDHSASAHEVVECNNVIN
                     IGEQTENYLMKEFGSLREAQSFAKSNRNKNIILIASTGMGKTETALIWIDKDKAFFTL
                     PLRVSINALFDRAKNIVGVGESNDTFLGLLHSTAIDYLEESNQENSSEIVDLAKLLSC
                     KLTFSTIDQIFKFPFLYRGYEKVYSTLAYSKVVIDEIQAYSPEIAAVLVKGIEMIHKI
                     GGRFMIMTATMPTIYIDELKKRGVMNSNLAELTCNTEKIRHCVSIVENSIDENLGKII
                     QSGMNKKVLVIVNTVKSAVEKYELIEEIVKPKGIDVNLNLLHSMYIQEDRAKLEKYIK
                     EFANSDRNGIWITTQLVEASLDIDFDELHTENSTLDSLFQRFGRCYRSREYEENSPNI
                     FIYTEKATGIGSIYDKDIVEKGLELLKTFINGKECVKMKEKYKVEMVKILYSKESLEG
                     TAFEKRFTSALNILDTITPYSLGSKDAQNILRNIEGYTVIPEDIYNKIEETLIKDYEE
                     LGQELINAYSNDDRQLINKIKSKRKKARREIIKKTVNLPIYKAKQNVIDIQVKGLEDL
                     KILLYKYDIYENKHTKQIFGKGVLISNEIDQFI"
     gene            17140..17691
                     /gene="cas4"
                     /locus_tag="KRO40_000859"
     CDS             17140..17691
                     /gene="cas4"
                     /locus_tag="KRO40_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas4"
                     /protein_id="HBH2091691.1"
                     /translation="MWLKFTKEGDFVPIDLEVLKVQGVKINYYYVCKRKLWLFSKGIT
                     MEQNSSRVLSGKIVHEDSYKRMKNKEILIDDILKLDIIKDEYVKEVKISSKMKEADEM
                     QLYYYLYYLKNSMGIEKKGTINYVKEKKQEELILTEEKERIIENTLININEINMQLSP
                     SKIEKKHYCTKCAYYEFCFVKEE"
     gene            17694..18674
                     /gene="cas1b"
                     /locus_tag="KRO40_000860"
     CDS             17694..18674
                     /gene="cas1b"
                     /locus_tag="KRO40_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated endonuclease Cas1"
                     /protein_id="HBH2091692.1"
                     /translation="MYKDYYIISNGDIKRKENTIYYYNLEGEKKILPVEQVDDIHIYG
                     EVDLNTKLINYISKYGVMLHFYNYYGYYSGTYYPRKKNVSGFSLVCQSACYLDKNERL
                     YLAKSFVESASYHILRNMRYYKVDESLIDTIKDELNDLNDVKEISELMGKEGRIRKTY
                     YKSFNQILKDDFEFYKREKRPPKDPVNALMSFGNSIMYTNVLSEIYKTQLDPTISFLH
                     EPSTKRFSLSLDIAEIFKPIIVDTIIFSLINNKRINKNDFEYQDKICYLSEKGKKKFL
                     QEFENKMQTTIKHRNLNRKVSYRMFIRLECYKLIKHFINDERYKVLKVWW"
     gene            18677..18943
                     /gene="cas2"
                     /locus_tag="KRO40_000861"
     CDS             18677..18943
                     /gene="cas2"
                     /locus_tag="KRO40_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas2"
                     /protein_id="HBH2091693.1"
                     /translation="MFVIVTYDIVEARSLNRIRRILRKYLTWTQNSVFEGNITEGKLH
                     KCISEIENIIDNSEDSIYVYEIKNPNSIKKKCYGIDKYSDEMFI"
     repeat_region   19127..20863
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=19127..19155
                     /rpt_unit_seq="gttttatattaactaagtggtatgtaaat"
     gene            21052..21480
                     /locus_tag="KRO40_000862"
     CDS             21052..21480
                     /locus_tag="KRO40_000862"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase"
                     /protein_id="HBH2091694.1"
                     /translation="MIKKLNNKDINKIMEIWEKSTIKAHDFISKEYWQNNYNTVKNEY
                     IPISDTFVYDDGDEIKGFISIIDKSFIGALFIKPKYQNLGIGGKLLDYATKKYKSLSL
                     AVYKDNKKAVVFYNKKGFNIVKEQVNEDSGFKEYIMEYSK"
     gene            complement(21935..22714)
                     /locus_tag="KRO40_000863"
     CDS             complement(21935..22714)
                     /locus_tag="KRO40_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091695.1"
                     /translation="MKVNENNINNIDEELGELSRKVYLESPDFWISISDKIIDKVFDE
                     MLLFFAVKYNYFNIVCFAIENNYLDLNMPSKNKKYTNIMEHLLDTSKQNEDKKIYNYL
                     LSLNKGNNLDERPILDELNCNISSDTFEKKDIYLPKYLCPSCNSNIFDTGYKVSNDIT
                     YKFSSKEAEPIEMCSEVSSIRCCNCDELLEDITLDKLYNLCKIQNCNNCGSNLTKVGI
                     IAKKKMNFDENTEKFKDVSTSYCCGNCDSEISLSQREHFKI"
     gene            23038..23583
                     /locus_tag="KRO40_000864"
     CDS             23038..23583
                     /locus_tag="KRO40_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HBH2091696.1"
                     /translation="MKNTKVNIQDLTKMSICVALLCISSYIYIPLPFTPAGVTAQTIM
                     INLIALILTPRQAFSTVGVYIMIGLIGIPVFGGGTSGIGKLLSPTGGFYFGFLFAALI
                     ISLLKGRNNDIKRYILITIFVGMPIIYFMGTVFMCYFNQMTVEAALFAAVVPFLIGDT
                     IKSVIASFLGTKLNNVLRRNL"
     gene            23615..24751
                     /locus_tag="KRO40_000865"
     CDS             23615..24751
                     /locus_tag="KRO40_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiolase family protein"
                     /protein_id="HBH2091697.1"
                     /translation="MKEVFILGGLRSHIGLKNGIFQFVQPELLGASVLKDLIKKYEID
                     KIDEIICGNAVGTGGNIARLMTLTAGVSNEVPAFTVDMQCASAMMSIDIAFSKVKSGQ
                     CDLIIAGGFESSSLQPMRTYHKNDKRYDTNNPNYTVAQFSPDDNSQNSMLEGAERVAE
                     LYQIEKADLDFWVKESHKRAKEAREEKILEDIISPINNSTYDEGIRDKMSQRLLDRMP
                     SILGKETITNAANSCLINDGASFIIICSKKYLEHVKKKPKAKIINTCTIGTDATLSPT
                     SAIQAMDKLLEIESLNYLDVSAVEFNEAFAVIDVLFQRKYPELIDRYNIFGGALAYGH
                     PYGASGAIIALHLLKALEKTKGRYGICSIAAAGGLGSALLLERV"
     gene            24755..26146
                     /locus_tag="KRO40_000866"
     CDS             24755..26146
                     /locus_tag="KRO40_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding protein"
                     /protein_id="HBH2091698.1"
                     /translation="MNYYELLRIKKERQKNKNFLIIDGEKYTYENILSYSEELGKQIS
                     LGENIPILIYSKNIMFQLISFFAINYSKNIPIICHYNLSKKVLDDILLKNNISIIISD
                     ESMDVIDLYDDNNNEVAKKVNFSIFNPKFNIYMYQYKKLINYLDKSICMGALSSGSTS
                     VPKVLYRTYESWAGFFPIQNGIFNISGESILFVNGTLSFTGNLNSIMSVLYEGGSIVI
                     SSGLNCKSWIRTIKQYNVTNIYLIPTKLQLLVKHLKEPVLKVVSIFTGSQLLFEDTAR
                     NLKKYMPKSEIILYYGASELNYITYLCYDELIEKPLSVGRPFPGIDIYIREGKIFVNT
                     EYAVYNATKPYSVNDIGYYDNDGYLIFEGRSDDIINIGGFKVSSTKIENEVKKIPQIE
                     DAIVLPYSDTIRGNQIVLFVITIDKITKKDLLIKMKDNLMKNEIPKKIIFLNSFPYTS
                     SEKIDRLALLKML"
     gene            26222..27097
                     /gene="dpsA"
                     /locus_tag="KRO40_000867"
     CDS             26222..27097
                     /gene="dpsA"
                     /locus_tag="KRO40_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit DpsA"
                     /protein_id="HBH2091699.1"
                     /translation="MSNQYDITVIGGDLRQVYMVKKLINKGYSVVTYGISNEIINGIV
                     GKSTSLAEALSKSSIILCPIPFTKNQVNIENTDDCLDATIDNLLINLSPNQILFGGNI
                     PTKVCKFCEQHSIQIYDFMKMNDVAILNAVATAEGAIAEAIKRSIINIHQSNCLVLGY
                     GRCAQILAKKLYALDANVCVGARNNDARSTANAFGYSSISLSQLDEKLLQFDYIFNTI
                     PECILTKERLEKVSQEVTIIDIASSPGGVDYSVVKEAGINATLCLGLPGKYSPKTSGE
                     ILVNAIENIINERRD"
     gene            27100..27690
                     /locus_tag="KRO40_000868"
     CDS             27100..27690
                     /locus_tag="KRO40_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit B"
                     /protein_id="HBH2091700.1"
                     /translation="MRLEGLTIGVGFTGSFCTYDKIFIELENLVKEGANVHTIFSDVS
                     QNIDCRFGNSEEFMKKAYELTGNKPIVTIEEAEPFGPKGIADIIIIAPCTGNTAAKLA
                     NGITDSPVLMAAKGHLRNDKPLVISISTNDALSFNFKNIGILLNSKNIYFVPFGQDNC
                     KAKPNSMIAHTELIIPTIELALENKQLQPVIKSPHQ"
     gene            complement(27897..28097)
                     /locus_tag="KRO40_000869"
     CDS             complement(27897..28097)
                     /locus_tag="KRO40_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091701.1"
                     /translation="MEKLKTISVFSLIISVILTIGGIGIVTYYVDNLFIRGLSVFVLI
                     MSSSFVSTTVRLIFEESKRYKF"
     gene            28601..31255
                     /gene="adhE"
                     /locus_tag="KRO40_000870"
                     /gene_synonym="adhC"
     CDS             28601..31255
                     /gene="adhE"
                     /locus_tag="KRO40_000870"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBH2091702.1"
                     /translation="MAHKEQVIIENKKENEVMSVGLDTVNNVESLVKKLAKIREAQKI
                     FATYSQEQVDKIFLAASLAANKQRVPLAIMAQKETGMGIAEDKVIKNHYASEYIYNAY
                     KETKTCGVIEKDEAFGMTKIAEPIGVIAAVVPTTNPTSTAIFKALLALKTRNGIIFSP
                     HPRAKNSTIEAAKVVLEAAVLAGAPEGIIGWIDEPSLELTTTVMKEVDLTLATGGPGM
                     VKSAYSSGKPAIGVGAGNTPAIIDDSADIKTAVNSILVSKTFDNGMICASEQSVIVLE
                     NIYNEVKKEFKERGAYLLDKDETEKIRNIILVNGGLNSKIVGQTACTIAKLAGFEVPV
                     DTKVLIGEVESVEIEEAFAHEKLSPVLAMYKASDFDDAVRKAEKLVEDGGFGHTSSLY
                     IDDVNQREKLDKFTSAMKTCRILINTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVS
                     ENVGVKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVALKELKDVMNKKRAFIVTD
                     TFLYNNGYTKAVTDLLDEMNIKYTTFFEVEPDPTLECAKIGAKAMREFNPDVIISIGG
                     GSAMDAGKIMWTLYEHPDVDFQDLAMRFMDIRKRVYTFPKMGEKANFVAIPTSAGTGS
                     EVTPFAVITDQDTGVKYPLADYELMPNMAIVDSDMMMNMPKSLTSASGIDALTHALEA
                     YVSMLATDYTNGLALQAIKSIFEYLPRAYDNGAKDPEAREKMANASTMAGMAFANAFL
                     GVCHSMAHKLGAFHHVPHGVANALLITEVMKFNSSDAPKKMGAFSQYKYPEALKRYAE
                     IASFLGLKGNSDEEKFQSLLVAIEDLKLKVGIPKSIKEFGVEESKFMDSIDEMVIQAF
                     DDQCTGANPRYPLMNEIKDMYLNSYYGR"
     gene            31531..33750
                     /locus_tag="KRO40_000871"
     CDS             31531..33750
                     /locus_tag="KRO40_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2091703.1"
                     /translation="MTGRNKSFTLITILFLTSLFLTMGYIYIEDTKHLLMSEAKIHIK
                     EVAVQGSQLAQRQIEKDLDVLNIFSNYYASNPDIPNEEKMKNLLDEMENQKFYTMAIV
                     DINGNAENTKGDKFSVKDREFFKNSIKGKKYVSSPYVDEVNKSIKKIAISVPLLNNDK
                     VVGVLYCTYNINTLMKLINISFYENNSISYVVKNNGTIILHPQGDSLSKNIYKLLKQD
                     NDIQEVNRLKKELQENKTGATVLNMLEERRYLGYATMDNGNSENNYIKDWNLIFSIPE
                     TVVFSNSKQIINRAVYAVLSIVLIFIAIIFYIIYIKKSNEKEILSLAYEDKVTYIGNQ
                     NKFYRECSKYLLDKPSLNYIIVYFDINNFKMINDTFGYEFGDNLLITIAKALKEELTE
                     GEVYARLSSDYFAIFCDYKNGRNKIIRKLDNIRSNIESNLSIVFEISLCVGIYFVEEG
                     EVDIQKAVNKANMARSVAKGKNINYAIYNEDVRNKLSEESMILDDIKIALVKNQFEVY
                     YQPKFSLVTGEMIGSEALIRWNHPEHGFISPAVFIPIAEKSKLILKIGRFVFERVCND
                     LYEWKKQGKKIVPVSVNLSRVELYQPDIVKFINKTIKMYNLSSDFIEIEITETVAINE
                     LNILKNVLNELRTYGFSISMDDFGTGYSSISCLRDMPIDILKLDKSFLGGIEHDERSR
                     NIAKSIVSLAKSLDLVVIIEGVESKEQAELMKQFGCDLVQGFYFARPMPAKNFLDLL"
     gene            34004..34666
                     /locus_tag="KRO40_000872"
     CDS             34004..34666
                     /locus_tag="KRO40_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-binding protein"
                     /protein_id="HBH2091704.1"
                     /translation="MIDISIDDKLKERWPNAKLGCIQAKVAVNKSSEKLINEINEFCD
                     TINQSLKVEDITKLDKIKDARNAYKELGKNPSRYRTSSEALVRRIIQGKGLYTINNIV
                     EINNLISIKSLYPVGTYNVSKLHSPVCFTVGDEGEQYKGIGKELINIENLPILSDSVG
                     KFGSPTSDSERAMITEDANEILICIFSFSQESDIEEYFGYAKELLKEYADGKDIETKI
                     IK"
     gene            35037..36446
                     /locus_tag="KRO40_000873"
     CDS             35037..36446
                     /locus_tag="KRO40_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L,D-transpeptidase/peptidoglycan binding
                     protein"
                     /protein_id="HBH2091705.1"
                     /translation="MIDGKEVKQESGQKNLKFKIAIVVGVLFVAYIGMAIFFRNHFYF
                     GTTINGVKASGKTVEQVNDLLTSSTNSYTLNLEERNNKKEQIKAKDIDLKFTPDDKVQ
                     KIKDSQSAIGWIGGIFKSKEYNNMITLSYNKDLLEKRFNALSCFDSKNVVEPKSAYPK
                     YDSTKNAYVIVPEVLGNKVKKDDFYKLVQNSINSGNTSISLDESKVYEAPNNTKDSEK
                     LKQAIKTLDKYVGVVVTYDFSDRKETLDGSEINKWLKVDSEKNYDITFDNDAMVEYTR
                     GLSKKYSTFGDSRPFKTATGKDITISGGIYGWLIDKKKEAEALVDVVKAGKNVTREPI
                     YIQKAVSRNKDDIGNTYVEISLSGQHMWFFKNGEMLVSTDVVTGDLARGFATPSGIYP
                     LNYKARNVSLTGQGYSSPVSYWLPFNGNIGIHDATWRNSFGGSIYKSSGSHGCVNTPF
                     SKAKKIYENIEPGTPIILY"
     gene            36561..36836
                     /locus_tag="KRO40_000874"
     CDS             36561..36836
                     /locus_tag="KRO40_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="HBH2091706.1"
                     /translation="MNEKLTKILEEAKNDDEFRKELIKTREQRDVMDSFCKVVTSRGY
                     DMTVGELFSMGEEYTSNLLKSVNGGAAYPIEDWSDWYEDFFIMLSNI"
     gene            37466..37777
                     /locus_tag="KRO40_000875"
     CDS             37466..37777
                     /locus_tag="KRO40_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091707.1"
                     /translation="MAFEIIKSIVEAEQTADSIKVKAVTDAESIRADAVNKCESIFAD
                     VKKQAKLMEETLIEKAVTDSRAEVDKILANAKSECLKIEKTAEERKSKAIEAVIGKVV
                     R"
     gene            37779..39704
                     /locus_tag="KRO40_000876"
     CDS             37779..39704
                     /locus_tag="KRO40_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HBH2091708.1"
                     /translation="MAIVNMNKISIVGLEAQKSQILKLLMNRGFVQIDDSAFLTEEEE
                     LKNYLVKDSEESEVIMLEQKMSHVNQAINIVSSLVKQKKSLLAPKREFNKIDSEKEGQ
                     VYAEALELNNLHKEIGTIRSNINLLNNNKSMLEPWVNFDIPLENMETKYTKTILGTVP
                     ISANIDALRVKLEDEIPESVIGIVNSDKLMNYVYLITLKETFDDVLEVLKEFNFSVVS
                     LPNEEGTPLQAIKKYNEMIIRQENVSKDKTEEIKRHADSIHMLENLYDFYTIERDQKK
                     IIERLVKTKTTFCLNGWLPSKRADELIKEITEKFNCCVQTEEGSKEEGFPILLENNKL
                     VTPFESVTNMYSYPSTKDIDPNTILTFFFVVFFGMMLSDAAYGLIIAVVCGFVVYKLK
                     IQKGEGNLIKLIGICGVSTTVWGLIFGGILGDLIPIKALINPLEDVMTLMGMSLLFGI
                     IHIYVGLGIKAYTLIRSGKVIDAIFDIGFWYLCITGVCLLIIPFVAGDIGVFSEVGKY
                     LAIIGAIGLVLTQGRSFKGIPVKLFKGFSSLYGITSYFADILSYTRIMALCLTTGVIA
                     QVINLLGAIAGPILAVVIGVVGHTINLLINALGAYVHTSRLQYVEFFNKFYEGGGVPF
                     VPFKYKTKYTSINKKEM"
     gene            39707..40198
                     /locus_tag="KRO40_000877"
     CDS             39707..40198
                     /locus_tag="KRO40_000877"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HBH2091709.1"
                     /translation="MEFLNALGNGQFLAISGAAIAALFAGMGSAKGTSIAGQAAAGVV
                     TEDPSKFGQLLVLQLLPGTQGLYGFIIAFLILSKAGIIGGDAIPTSAQGLQLLMAGLP
                     IGLVGLVSGIAQGKAAAAGVGIVAKRPEELGKAITFAAIVETYALLGLLVSFLAYNGI
                     AIG"
     gene            40250..40813
                     /locus_tag="KRO40_000878"
     CDS             40250..40813
                     /locus_tag="KRO40_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit E"
                     /protein_id="HBH2091710.1"
                     /translation="MGNEQKMIDRIIADAKQEAQEILDKAKSEADLKVNSANEKAEKE
                     MASYTKLAEAEAEKAASKEISGAYMEAKKQILSKKQEILEEVILEAKNKLLNLKDNEY
                     EEIILNMIEKSNCTDDSEIVLSKKDKKTLKDVLSKKGIKVSDETRDITGGFIVKKGDI
                     EYNYSFEAIIAVEHEYIEQIAAEILFN"
     gene            40828..41805
                     /locus_tag="KRO40_000879"
     CDS             40828..41805
                     /locus_tag="KRO40_000879"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit C"
                     /protein_id="HBH2091711.1"
                     /translation="MAEEKTYPYAVARIRVLEKQLLNRQMFIQMAEAKSPEDSLRIIA
                     EAGYADTSNNNIHNFENILTQELSKTYEILKSLAPEEKFVDVFLYKNDYHNLKVLIKE
                     EISGVDGEKYLIDGGTIPLIKLRESLANRSFSDLPKIMSSAILEAFDVYNKTQNGQMV
                     DIVLDKATFTSMKETAKESQNKFVIDYVMKVCDLTNLKSFIRVKNMKKDFDMFMNVFV
                     SGGSLDKEKFLEAFSSDTPASCFKSTSYSDVCKNGMDSGFTVFEKLCDDYLMEYVRGA
                     KFKPLTLEPLIAYLYAKESEIKTIRIILTSKLNNIDADTIKERLRDAYV"
     gene            41792..42115
                     /locus_tag="KRO40_000880"
     CDS             41792..42115
                     /locus_tag="KRO40_000880"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HBH2091712.1"
                     /translation="MLMYKVGVVGDKDSIMGFLALGIDIFPAYDSDEIKKSIHKLVED
                     EYAIIYITEQASLLAKESIAKYKDYQLPAIIVIPGIGGSMGLGMNEVRESSKRAIGAD
                     ILFKE"
     gene            42232..44010
                     /locus_tag="KRO40_000881"
     CDS             42232..44010
                     /locus_tag="KRO40_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HBH2091713.1"
                     /translation="MKTGTIVKVSGPLVVAEGMRDANMFDVVRVSDKHLIGEIIEMHG
                     DKASIQVYEETSGLGPGEEVVSLGMPMSVELGPGLISTIYDGIQRPLEKMYDISGTNI
                     TKGVEVSSLDRTTKWEFKPKKSVGDKVVAGDIIGGVQETAVVECKIMVPYGVKGTIKE
                     IYSGEFTVEDTVCVITDEKGNDIPVTMMQKWPVRKERPYREKKTPDSLLVTGQRVIDT
                     FFPITKGGVAAIPGPFGSGKTVTQHQLAKWADADIVVYIGCGERGNEMTDVLLEFPEL
                     KDPRTGESLMQRTVLIANTSDMPVAAREASIYTGITIAEYFRDMGYSVALMADSTSRW
                     AEALREMSGRLEEMPGEEGYPAYLGSRLAQFYERAGKVNCLGMDEREGTLTAIGAVSP
                     PGGDTSEPVSQATLRIVKVFWGLDASLAYKRHFPAINWLTSYSLYQEKVDVWADKNVN
                     DNFSAQRAQAMKLLQVESELQEIVQLVGVDSLSDGDRLILEVTRSIREDFLHQNSFHE
                     VDTYTSLHKQYRMMGLILKFYKSAQDAIKQNVTINDIIKLSVLEKIGRAKYVEEGDID
                     AAYDSIEDEIDNELADLIKKRGAEEL"
     gene            44007..45380
                     /locus_tag="KRO40_000882"
     CDS             44007..45380
                     /locus_tag="KRO40_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HBH2091714.1"
                     /translation="MIKEYKSIQEVAGPLMLINGVEGVKFDELGEIELSNGEIRRCKV
                     LEVNGDTALVQLFESSTGINLAESKVRFLGKSLDFGVSPDILGRVFSGMGRPIDGGPE
                     IIPDKRLDINGAPINPAARDYPAEFIQTGVSAIDGLNTLVRGQKLPIFSGSGLPHANL
                     AVQIARQAKVRGTDSKFAVVFAAVGITFEDAEFFISDFKATGAIDRSVVFVNLANDPA
                     VERVSTPRMALTAAEYLAFEQDMHVLVIITDITNYAEALREVSAAKKEVPGRRGYPGY
                     LYTDLATMYERAGKMKGHEGSITMIPILTMPEDDKTHPIPDLTGYITEGQIILSRELY
                     KKDIQPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFAAYSRGKDAKELMAILGES
                     ALSEIDLMYAKFADEFEKEYVSQGFRTDRTIEQTLEIGWKLLSMLPKSELKRIRDEYF
                     EKYMPKE"
     gene            45386..46054
                     /locus_tag="KRO40_000883"
     CDS             45386..46054
                     /locus_tag="KRO40_000883"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HBH2091715.1"
                     /translation="MARLNINPTRMEMTRLKKLLKTATRGHKLLKDKLDELMKQFLEI
                     VRENKRLREEAENALDTAYKNFIIARAVMSQEYLGSALMMPKQSVSVDVSTRNIMSVD
                     VPVFDFKTENNQSDIYPYGLAFTSGELDSAMEAFSDAMQPLLRLAESEKSAQLLAQEI
                     EKTRRRVNALENVMIPNYIETIKYIAMKLEENERASTTRLMKVKDMVLKKALEEKKKN
                     DLVV"
     gene            46331..47380
                     /locus_tag="KRO40_000884"
     CDS             46331..47380
                     /locus_tag="KRO40_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2091716.1"
                     /translation="MKEFIFTCLCIVVITFMTSCISTTPQTTQGKGNNKLTIYAALEE
                     EQIAYYMEGFREEYPNIDVEIVMDSHGVIASKLLAEKDNPQADIIWGLSAMNMIELKK
                     DGALEAYKPKNYDKVDKKFKDTEDDVSWVGMSVPETAIVVNYKELKKLGIDIPKSYED
                     LIKPEYKGLITMPNPASSGTGYLTVSGLIQMMGEKDAYNYMDKLHKNIATYTHSGSKP
                     AKLAGSGEYPIGITLGYRATQQLSSGEPIEVVFPKEGSGWDLEANALVKKDNIKKEAK
                     LFLDWAISDSAMDRYAHEVAVTSIKTDNPVPKGYSKQPFEQLIKEVDLNSAAKNRSTV
                     LKTWESKYGSKSESK"
     gene            47476..48465
                     /locus_tag="KRO40_000885"
     CDS             47476..48465
                     /locus_tag="KRO40_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2091717.1"
                     /translation="MSYLKINNVFKSYDQKRVLNNISLDIEEGEFLCLLGPSGCGKTT
                     LLRIIAGLEDVNSGTIILQDKDITNLEPSKRGFGIVFQSYALFPNMTAYNNIAFPLKE
                     RKVSKGKIDNKVKEVLETVGLTNEAHKYPKALSGGQQQRIAIARALALEPKFLLLDEP
                     MSALDAKVRHKLRMDIKRLQKELNITTIMVTHDQEEAITMADKIAILNGGDIMQIGTP
                     EEIYQNPQNLFTAQFIGDTNCFDNGDSILTVRPEYVQIEKSTKENYQGIISNIEFRGN
                     LLRVEIKDKLNENFIISDASIKEWVNLNLVEGDLVKISIDEKYYLKYPKVKGA"
     gene            48470..50188
                     /locus_tag="KRO40_000886"
     CDS             48470..50188
                     /locus_tag="KRO40_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBH2091718.1"
                     /translation="MNNNAISSKSISLKSKMNLDIKKCMLTVLVMSLVIFLLAPIIYL
                     FVQAFLDKDGVFVGLQNFQEYLASESLLNSLKNTVFVSVISTVISLTLALVYAYALTR
                     TKIKFKGFFKSLAMFPMFAPTMMHAIGLVYLFGNQGLVTNLLGVHVPIYGAVGIILAQ
                     IIYVFPQSFQILYISLSSTDYRLYEASNTMGISKIREFISITIPSIKYSLISSAFVSF
                     TLCFTDFGAPKVIGGEFNVLSIDVYKQIIGQQNMPMGATVSILLLIPAIISFIVTKKI
                     EKNQNSYITSKSIPYKVKTNKLRDSILGGVVGIIAFGIIAVMLTVILSSLISVWPYDL
                     RLTLEHFSMKNSIDGIKPFINSIKMSLLTAILGTSFVFLFAYLNEKTEKAPYLKSFGY
                     FLSTLPMALPGLVLGIAYVLFFNKLEFNFMDTIYIKNLFNGLYGTLLIMVICNIVHFF
                     SVAFITATTAIKKVDKELDMVAKSMGINSASILKNVTIPLCLPAVLENFMYFFLNSMV
                     TISALVFIYTASSKVAAISIVQLDDKGSTAQAASLAVLILVTNILVKVIYEFIKNRLE
                     KRTNFN"
     gene            complement(50270..51424)
                     /locus_tag="KRO40_000887"
     CDS             complement(50270..51424)
                     /locus_tag="KRO40_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2091719.1"
                     /translation="MKINKKFNRVDMQVSILTAIIVIISSSCVYFFNYTLTYKSMIYS
                     LSERSKHIYEYVERNIDKNTFTEINSKEDQSKKSYKSSKILLESVKNTTGVMYLYTAK
                     KTKDGSLVYVVDGLNSSRSDFRNAGDLIEKEIWGDLNKALDNHILLPKKIKSTSWGYI
                     FISYFPIHNDVGKVVGVIGIEFEAKHQYNTFKFISIVTPIIALLTCLISALIAVILFK
                     RISNPTYTDFANTDYLTGLKNRNAFEIDMNNLNNSNLKNLISIISIDLDGLKKINDKF
                     GHQTGDLYIKQASKIIQYVINKKYIVYRIGGDEYIIILKNLSHKEINNIINNINLKIV
                     EENSTNELKLSMSIGYAIFDEKVDVSLFDTYRRADSQMYDNKRKINKQYQ"
BASE COUNT        20299 a         5491 c         8918 g        16856 t
ORIGIN      
        1 ttaaaaaatg tagataaaaa ttgttttatt aagaaaaaat taatatgttg acaaaattta
       61 agtgctcatt taaactatta attgataata atattcaata ttaaataata ggaggcgtta
      121 tgaataaata tcttctaata aatccagtgg cagaaagaat gtatggagaa aagtttcacc
      181 ttattaaagc aaatttgata aaaaaggggt acataatagc agaatgtgaa ccacagttag
      241 aatatgtaaa aaagcagtac aaagagtata caaaaaagac taaaaataca atgttggatt
      301 gtagatgtcc agaaagtata agtcttttaa aaagaaataa tttgataaat gattttgaag
      361 tacctatgat agaaccaata ttagtaagga cttgtagggt tttatacgat aaatatataa
      421 aaagtaaaga tgatatgttg gtagtaacct gtccatgtac acaattaaga gactttgcaa
      481 gtgaaaagtt taaggataag ggtaatgcta tgttttatac atggaaagag tttgctgaac
      541 aagaaggtgt aaaatcactt ggaaaaatag atgaatcacc aattccatta ggatatttca
      601 aagatacttt tgaaaaagtt cttgaagtat caagtgaaga cgaaatatta agtgaaatac
      661 aaaaaataag aaatggtttt gaagataagt atgacatagt agaaatgttt tattgtaaag
      721 atggttgtaa taatggagat ggtttgtaaa tggtcaataa atttaataat aagtttttaa
      781 ggctagtaaa gagtgttctg atatttttta taattctttt attatggaaa attacaaatt
      841 atcttggtat ttggagtgat tatatattac catcacccga aaaggtatat agtacatttt
      901 taaatatgat aagtgatggt tcaatattta ttaatgtata tgcaagtatg aaaagagttt
      961 tgataggttt tgcaataagt actgctatag gtgtgccttt agggatattc tttggaattt
     1021 atagtggagt atacgaatac tttaaatctc taataaattt tttaaggaat acacctcccc
     1081 ttgctttaat accaatgctt atattatggt ttggtatagg agaggaatca aaaattataa
     1141 ttatagtttt agcatccttt ttcccaatct ttacaagcac attgaaaggg attaaaaatt
     1201 gtgactcaaa actgattgaa gtgggtagag tatttgagtt ttcaaagctt cagataatat
     1261 ttaaaataat aataccaaat gccattcttg atattgctgt tgggttaaag ttagctcttg
     1321 gatatagctt tagagcaatt attggggcag aacttgtagc agcttcatct ggtcttggat
     1381 acttgatatc tgatggaaaa gaaatgtcta gaacagatgt tgttattgta ggtataatcg
     1441 taattggact tttaggaata attacagatt acatattttc gattattgtg aagaaggtaa
     1501 gtaagggaaa gatggtggaa gcatatgaat aatttagtat gtgactctgg atatataatt
     1561 agaaatttat ataaaagtta taaagttgac aatgaagaac atgtagttct tagtgatatc
     1621 tctttaaaca tagatagaaa ccatataaca gtaattttag gtgaaagtgg ttgtggaaag
     1681 actaccttgc ttagagcaat tgcatcactt gaaggtataa atagtggtga aattaggttt
     1741 attaatgata ataaagagta tagacctaat gttggttttg tttttcagga gagcagatta
     1801 atgccttggt taaacgtaag tgaaaatata gcttttcata atcaaagaaa aaatactatt
     1861 ttaaacaagg tgcttagaaa atttaaacac aataaaagaa ttagcagtaa aattataaat
     1921 gataatttta gaagcttaga aacaaatgat aatttgaaca aatcaaataa atataatagg
     1981 aaaagtaata ttgatgtaga aaaatatctt aagatgatga acttgcagaa atttaaaaac
     2041 tcttatccaa atgaattgtc aggaggtatg gcacagagag taagcatagc tagagctctt
     2101 tctttcaatc cagatatgtt gcttatggac gagccttttt cggcattaga ttattttaca
     2161 aggattgata tgcaaaatga agttataaga atacataagt caactaataa aggcgtgata
     2221 tttgtaactc atgatattga tgaagcgtta aagataggca agaaaatagt tgttttcaca
     2281 gacgaaagaa aaataaaaga atttaatata gaagatggtt ataatagaga tttaacttca
     2341 gattactata ttaaattaaa aaaagatatt ttaatgacaa tgaaatcaaa taaaggcatt
     2401 taaagaaatt aataatattt taaggagtaa agtaaatgaa attaaaaaag ctattgatag
     2461 gtataacgat attaacactt gcaacagcat ctttagctgg atgtgctaaa aaaaataatg
     2521 gagaaaaact ttcagaaata aatttaactt atgtaaaatc accattaaat gttccttcta
     2581 taattcagaa acaggatgat ttatttggaa aggaatttaa aaaggataat ataaaagtta
     2641 acttccacga aattactaca ggtccagagc aaacacaagc tttagctgct ggagaaatag
     2701 acttcttaca tgcactaggt ggtacatcag ctttaatagc tgcatctaat ggagtagagt
     2761 taaagatatt aaacacttat agcaggtcac caaaaggatt tatgattttg actaataata
     2821 attcaataaa atcagcagca gatttagtag gtaagaaggt ggcaggccca aaagggacta
     2881 tattacatca ggtattgatt tcagcacttg ataaagaagg attaagtatg gatgatgtgg
     2941 aatttgttaa tatgggtatt ccagaggcat cagcagctct ttctgatggc agcgtagatg
     3001 ctgcattgat tgctggtcca gcagctctta aagctatgaa gtcaggtagt aaacttgtag
     3061 caaatggtga aggtttagta gatggtataa tagtaactgc tgttagcaca gactttgcag
     3121 agaaacatcc agaaatagtt gaaagattta tgaaggttga aaaggaaact ttagaatatg
     3181 taaataataa ttttgatgaa gctatggaaa aagtagctaa agaagttgat ttaagtcttg
     3241 aagaaactaa agaattatat gcttggtatg attttagttt agatataaca gataaagaca
     3301 tatcttcgct tgaagataca caagacttct taataaaaaa taagttacaa gagaaaaaag
     3361 tgaacataaa agaattaatc tataatgcta agtagaaact atgataaaat aatactaagt
     3421 aagaaatata ataaaagttt aagttacctt attaaggtaa ctttttctat tttgaattag
     3481 taatttcaat ttattttaga atgattagtt gataataatg attaattaat cataaaaaga
     3541 tactttttta tagagtttta ttaagatgtc taataatatg gttatactta tgaagtcagt
     3601 aattgtgaag ttagtaatat gattaaattt atatattgca aaaagattat aatatattaa
     3661 aattggactg ttatatgatg agtaaatagg tatattagga ggaattatat gagttataaa
     3721 gtatatattg tggaagatga tatatcaata agtacattac ttaaagatta tattgagaaa
     3781 tatggatttg aagtgattgt tgaagagaac tttgatgata taatgattac atttgaaagt
     3841 tttaagccac acttagttct attagatgta aatttaccta aatttgatgg tttctactgg
     3901 tgtagatgta ttaggcaaca gtcgaattta cctataattt ttatatcagc tagagatggt
     3961 aatgtagacc aaattagagc tttagaaagt ggagcagatg attatataac aaaacctttt
     4021 tactatgatg tagtaatggc aaaaataaag agtcatataa gaagggtata tggtgaatat
     4081 tcacctaaaa tagacgaaag aatagtggag ctagatggat taaagtttta tccagaaagg
     4141 ttagaactag aattaaatgg tgagaatcta attataacta aaaaagaagg tatactgatt
     4201 gaatgtctta tcaagagata cccaaaagta gtaagtagag attatctttt agaaaagata
     4261 tgggatgata ttgagtttgt agaggaaaat actttaaatg taaatgttag caggataagg
     4321 aaaagatttg aggaattagg tatagataat gctgttcaga ctgtccgagg gttaggatat
     4381 aaattaaata agaattggta aggagaaagt atgaagttat ttttaaaaga ttataaaggt
     4441 tatattttta tatattatat aggcatagtt atgacaatta tttactgtaa tcttatgaag
     4501 tttattagtt ttggagagag tttatatatt cttttattta gttcttttat attgttatgt
     4561 tttttaatat ataagtatta taaaaataga gaagtatata atctgtttga aaaaggagta
     4621 cattctttgg aggagtcatt tttgtattta ggaagctcat tcttggggag aaatatatca
     4681 gttattttaa aacaacaaca taaattgtat caatcaatga tacaagagca taaaaagata
     4741 catagtgaac atttaacttt catcaaccaa tggattcatc agatgaaaac accaatatca
     4801 gttataagcc ttcagcttca agattatgag ggagaagaag taactgaaaa tataagaaaa
     4861 gaaatagata gattaaataa agggttagat atggctatgc attttgcaag ggcagataat
     4921 tttcagaaag actttatagt tgaaaaagcc aaattaaatg aaattgtatc tagtattgta
     4981 aatgaagaaa aaaggttatt tataaaaagt ggaatgattc ctaagattca agtagacaaa
     5041 tttacttatg tttatacaga tgtaaaatgg atgaaattta taataggtca attaattaca
     5101 aatggagtga aatattctaa agattatagt aactacctaa ctataaaatc tgaagaaaat
     5161 aataaatatg taattttaag tataatagat gaaggaattg gaattgtttc taaagattta
     5221 aaaagggtat ttgacccatt ttttacagga gaaaatggtc gtaagtttgg agaatctaca
     5281 ggtatgggtc tttatctagt aaaaaaggta tgtgatgatt taggtcataa agtaagtata
     5341 aaatcagaag taggaaaagg tacagaagtt tcaatctact ttaataaaga tgtaaatagt
     5401 ttaataaagg tgtaaattat ctgttacaat agggttttta gttaattgta cttttttatt
     5461 atacaattta ttaaatgaaa tattcatagt taaataatca aaatttaaga gagtttattt
     5521 gcaaacctta catagatgta aggtttgtgt aatgtttgca gatagttaaa ttttctaatc
     5581 taaattacaa ttaatataag aaataacata agagaaataa cataaaaaaa gaaattttgt
     5641 aaaaaaggaa ggatgtttat tgatgagttt agatgttatt tttatattga aatcagtcat
     5701 aatagctata gtagaggggc ttacagaatt tattccagtt tcatctacag gtcatatgat
     5761 tttggttggt aatttaatag attttaaggg gcaatttgct gaaatgtttg aggttgtaat
     5821 acaacttggg gctatattag cagtagtagt actttattgg aaaaagataa aagatagcgt
     5881 tatagaattt tttaaattta tatttactgg cggaaaagaa ggaaagattg gttttagatt
     5941 tggaatgaat gtaattatag gttgtatacc atttgcgatt ataggagttc tattttacga
     6001 taatataaaa tcattgttta atttacaatc tgtaattata ggatttatag tgggtgggat
     6061 tttattatta gtagtagaaa ctttgtttag aaaaaagaat cattccacag ataatataga
     6121 taaaattact ccaatacaag ctttaaaggt tgggacatta caagttttgt ctgcatggcc
     6181 aggtatgtca aggagtgcat ctactattat gggtggatgg atagcaggac ttaattctcc
     6241 tacagcagct gagttttctt tctttttagc agtaccagct atggtggctt cttcaggaaa
     6301 agatttattt gaatttgatt attcaataat gacaccaaca ttgtggattg ctttggtagt
     6361 tgggtttata gtagctttta ttgtatcaat aatagttatg gaaaaattcg tgaatttttt
     6421 aaagaaaaaa ccaatgagag tgtttgctgt atacagaata atcatgggtg tagtacttgc
     6481 agtattagct tttactaaca taattagtgt atagaaaaaa tagatttatt atctataaaa
     6541 attaaactaa gataaattat aattaacaat tatatatatg ttatttcaaa aattaaatta
     6601 ggaaggatag ttaaataatg aaaattttaa ctgtaaataa tttaagtaaa gtatatggta
     6661 aaaaaataat tttcaacgca ttaaatgaca taaattttag tatagaagat ggagaatttg
     6721 taggaattat gggtccatct ggtagtggaa aaactactct tttaaatatg atttctacta
     6781 ttgacaagcc aactacagga actatggaat taaagggcaa gaatccttta ttgttaagag
     6841 gtgaggaact tgcattattt agaagaagag agttaggttt tgtatttcag gattttaatt
     6901 tattggatac attaactata ggagaaaata tagtattgcc attgacatta gataaggtca
     6961 gtgtaaaaga gcaagatgag agattgaatg aagtatctac aatattaggt ataaaagatt
     7021 tattaggaaa aagaactttt gaagtatcag gtggtcaagc tcagaggact gctattgcta
     7081 gagcattgat taacaatcca tcaatacttt tagcagatga accaacaggt aatttagatt
     7141 caaagtcatc aaaggttgta atggagctat ttcaaaagat aaataaagaa aataaagtta
     7201 ctactatgat ggtaactcat gacccattag cagcgagcta ctgtagtaga atcttattca
     7261 taaaagatgg gtctatatat aatgaaatat ataagggtag tagtagagag cagttttatc
     7321 aagagataat ggatgtactt acattattgg gaggcgataa ctaatgaata taaaacagtt
     7381 tgctattaac aatatttcaa gaaatattaa agcgtattta ggatacttag caagtattgt
     7441 tatatcatct tcactgctat tttcttttat tatgtttaca agtcatccag atttagatgt
     7501 atctcaattt cctgattatt taaaagaagg tctcaagatg agtaagataa ttgcatatct
     7561 attcttattc ttctttgtgt tttattcagt tagtgtgttt cttaaaagta gatataaaga
     7621 atttggaata ctttatatta caggtatatc aaaacgccaa gtaatgaaat taatctttat
     7681 agaaaatatg ataataaata tagtatcttc tgtaattgga ataataatag gcttaatctt
     7741 tgcaaagata tttttagtgg ttatgtctac ttttttagaa ttatcaccat taaaattcta
     7801 tataccattt aatgcgatat tgtctacttt aatctatttt atgattttag ctgtattaac
     7861 atcaatattt acttctttta tagttaaaga aaatcaggtg ttgaagttac ttaaaggtac
     7921 aaaaactcca aaaccagagc ctaaaacatc actaatgctt gctatattaa gtatttgttt
     7981 gtttataata gcgtattata atgctattac ctcaaccgac caatatacaa catatctgcg
     8041 cttagttcca gttacatccc ttactatagt agcaacttac ttgttctttt ctcaatttag
     8101 tgtatttttt atgaagaagc taaaattaaa caagagattt tatagaaaaa atacaaatat
     8161 gctttggatt tcgaacttga tttataaggt aaaggataat gctagaatat ttttcttgat
     8221 aactataact tctgcagtag catttactgc tataggtaca gtttattcct tttggaaaga
     8281 tgtagagcgt caaattaatt taatatatcc taacacaata tattattcaa caatgacatt
     8341 gcataatgac cctaaaaagc ctgatagcaa agaaaaagac aaggaaagaa tgatgtttat
     8401 agaaaataat ctaaaaaaag agaatgtaga ctatacaagg actaatggtg aatttaaaac
     8461 tgtatttccc aagaaaagtg attttaatgt cagaattatg aaagaatcta agtacttaga
     8521 aattacagaa actatagggg ttaagcctat aagttttgaa gataatgaat gtatatcatt
     8581 attatcatca agtttaccag gaaataagaa catcaaagaa aatattattg tagggaatag
     8641 aggtttaaag gtggcaaaac aagtggaaga atgtgttatg ccagcatatt acaaaaatat
     8701 gtatgtggta aaggataatt tttatgatag tatagaatca aaatttatag tggatagatt
     8761 tactgcattt gaagtagagg attcaagtaa aactatagag atatgcagaa aatttgaaaa
     8821 taaatttaat aatgagtcag ggatgcaacc atatttgttt ttctctaaag aattaatgat
     8881 aggaactggg aaattaatgt attctacatt tatattttta gcaatattta taggtttaat
     8941 tttctttgtt actacaagta gttttttata taataaattt tatatggatt gccaagttga
     9001 taagaaaaag tatgaacagt taaataaatt gggtatgaca tataatgaga ttaaaaaagc
     9061 ttcaacaatt gagattggaa tagtattttt gtttccttat gtagtggctg ttatacattc
     9121 aatatttgca cttactgcac ttaaaaattc ttttgatata gaagtagcat catcagctgt
     9181 tttggtaatg ggaagcttgt tcttggttca aatagtttat tttttaattg taagaaataa
     9241 ttatttaaaa gagataaggt taaatttagt caatttttag ttactattat taaatgataa
     9301 taaaaagggt ttagaattaa ttaatattac tggaattata gatgtttatt ttttcagtaa
     9361 tattttttat tgtattaact attaaaattt tgtacaaata taaaatataa tatggtaaat
     9421 gtcaaaatta taaaaaaatt ctacttatat aaaatataaa gaggttatat gtacatatgt
     9481 gtagaaataa ataataaaaa tatcaattaa tgttattagg gggggttact cattagtaaa
     9541 ttagctaata cacttagaat gatgatatta attcaaagca gaggcaaaat gaaatgcaaa
     9601 gaattatcag aagagttgga agtaagtgaa aggcaaataa aaagttacaa gatgtattta
     9661 gagcaagctg gtatatttat aaattcaaca cctgggattt atggtggtta tgaaatagat
     9721 aaatgtaata gcatctcatt aattaaatta ttagatagtg aagtttcaat tctagatatg
     9781 ataaattcac agttagagta taataatgat atttacaaaa atgaatttaa taatattgta
     9841 gaaaaaataa aagcagtatt aaatacagga gaaaaaagcg atacatatat ggattatttt
     9901 acagttcaag cacaatgtaa ttgtgattat gagtctgaaa aaaataagtg taatgaaata
     9961 attagagcat ataccacaaa acacaaattt tggatagaat attattcatt aaattcagga
    10021 aatagtgaaa gaattgttca tccatatggt ttatttaatt ataaatcaga tacttatatg
    10081 gtagcttttt gtgaaaaaag atttaagttt atagacttta aattatgtag aattaaagat
    10141 tataaggttt tagaagaaaa atataatgta gataaaagtt ttagttggga tgaatatagt
    10201 aaaaatagta taggaattta taagggagaa gaaattagtg ttgttataaa aattagtcat
    10261 ccattttcaa caattataaa ggaaaaagtt tgggttaata atcaacaaat catagaatat
    10321 gatgataaat ctataatgtt taaagctaaa atgagaggtt atgaggagat aaaaagttgg
    10381 attttaagta tgggagctta tgttgaggtt gtagaaccag atagacttag aaatgatata
    10441 ttgttagaga ttgaaaaaat gaaaaaaatt tactgatttt ttcaaataat ttatacttgg
    10501 accaatatac ttcacggtct agtgttaata tattaattga gagaggtgat attatgaaaa
    10561 tgaaaattga atttagtaca ggttgtatac caatatctta taattcgctc tttatgagta
    10621 ttataaaaga agcaataaga aaatctaatg aagattacta taaaaacatg tactattata
    10681 aagaaaagaa taataaaaaa actaaaaatt ttacattttc ggtttatata aaaaagtata
    10741 gtattgaagg tgacaatttt attatagaag ataaagtaat attaaatata agtactccag
    10801 atttagaatt gggttttcat atatacaatg ggttaatgac ttctaaaaaa tgtttatata
    10861 aagactatga acttacaaga attagaatcg atttatcaag agaaaagaag gtaacagaag
    10921 aaagggtact atttaatgca ttgtctccaa tttgtgtaaa gtctaaagaa ggaaaattct
    10981 tggagataac tgatgataga tacatagaag aactaaacta tataactaat gaagtggtta
    11041 aaaattatag ggggaatgga ttaaaaagaa agttagaatt tgaaaatata ggtctcaaaa
    11101 aggtagtagt taaagagagt ttaagagaat ttaaaaaaat aacaggtaaa gagtatcaat
    11161 atattaatgg ttacaaaggt aaatttatat tgaaaggtga tattgatgat ttaaatctta
    11221 tctacaatct aggaattggt tttagacgtg ctcagggatt tggagatgta gatattttag
    11281 aatggaggtg agataaatga agttaagagt ttatagagga gattggtttt ttaatatggg
    11341 tatagttgga tttttaaata taataaagaa agcagataaa caagctgaaa tatttattat
    11401 ggaagattat atcgaatttg atagcttatt tcttgaaaac tttcatgagt attattttaa
    11461 ttactttatg gatgaatatg atgtatcaaa aagaattaaa aaaaatattg attatagtat
    11521 aaattttatt aaatctaagc ctgatagaat caaagatgga attaagaaaa ttaaagatag
    11581 tgtgaaacaa caaaatgata agattaaaaa atttgatgaa gaaaaattta acctgataaa
    11641 agagaagcta gatagtatgt ctaagataaa aagttatgat gaatttgaca gtttagaagc
    11701 tttagtagat gagactatag atatatttaa aataaaatca ataaatgaca ggcttacagc
    11761 aaatctttat aaatatgtag ttcaagataa ttattttgga caagttagtt tttttaatgt
    11821 tgctaaggcg aaattagatt tagatggatt aaaacaggta atgtttaatg attatttaag
    11881 acaaattata tattttggag agttagaaga tttattagaa gagaatgact atgataagtt
    11941 gaaaaactat ttaaatgata gattaaatag tatagctaag gatataaatg aaaaaaaagt
    12001 tagtaagtct agtataaata ctatagaaaa aattatgaag gaaataaata aaaactttat
    12061 aaagaaaaat aaaagcatag aagatataaa aaagtatatg gatagtttag aagtatgtga
    12121 aatgtgtggt ttatataagg gaatattaga tgaatactca gaaagtaatt ttgctccact
    12181 tggagtaagc accaataatg ctaggaatat gttttggaat caggcgtatg taccatcaat
    12241 atgtgatatt tgtaagctaa tattgttctg tactccagca ggggctactt atacaagaaa
    12301 gaattattta attaatgaag aaaatgagtt ttatttattt gttaacatgg atacttgtat
    12361 aaatgagctt tttgaaagaa ataatagttt aaaagctcaa aaaagtgagt attcagattc
    12421 caaagaggaa aatcctttta atcagcttat aaaaagtata gtagaagaaa atacattgaa
    12481 aagtgaatgg caacttcgta atatactttt tgtggaattt aaagcaagta tagattctaa
    12541 aaaatgtaaa ataaattatt ttaatattcc aacttattta gcaaaatttt ttacagataa
    12601 gtatgcaaat aaaaaaatac aaagtatcta tgattacaag cttaaatcaa atgtactaga
    12661 tttactcttg aaaaataggg acttgaagca tctaattaat aacattttaa gaaataaagt
    12721 taaaaatgat atggaaagca acaacaaatc aaatatatca ggaatagatt gttttagagt
    12781 agtccaatta agagcattaa taaatagcta caaaaagggg gtatataaaa tggatagtaa
    12841 aaatttggag aagaatgatg aaaagctgag aataatttat tatttaggtt gtgatataca
    12901 tgactatttt gttaataaaa attctaaaaa taaaataggt ggagtaagct ataaactttt
    12961 aaattcagtt aaagtcggaa ataaaagtga ttttatggat acaattataa gagtttttat
    13021 gtcagctgaa aaacagatgc cagcatttat tttagatata gaaattgaaa aagatttaga
    13081 ctttgaatct ataggtcatg cttttatatc tggattaatt tctgggaaat atgaaggaaa
    13141 agataaacta ccaaacgaaa aggaggaaaa ataagatgaa aagagggtta acatttacag
    13201 taatagcaca agctcaaagt ttaaactatg gtgaagggat aggtaatata tcagaattaa
    13261 aaaaattaag tagagatgat ggaaatatat atacatttgc atctcgccag tgtttaagat
    13321 atgacatagt acgattagca gcagaattgt ttaattggaa tttacaggtt gtcgataaag
    13381 aaaaaggtac tattcaattt aaagataata taagtataag agaatcagaa gaaatggatt
    13441 tatttggata tatgaaaaca aataaaaaag atgagaaaga taaaaaagga ggttctttga
    13501 ctagagaagc tactgtaaga ttaagtaatg cgatttctct tgagccatat agaagtgata
    13561 tggatttttt aaataataaa ggatttgcag atagaatagg agaacaccct aatcttgcta
    13621 acatagagca acatttaagt tactatacat atacagtgac tatagattta tctaaaatag
    13681 gcaaggatgg agagatagaa cttgataata aagagaaatg tagaagagta gtagaatttt
    13741 tagaaataat aaaagtattg aatagaaata ttagaggtag acaagaaaat ttatctcctc
    13801 tatttgtagt aggaggagta tatgaaatag caaatccatt tttcttgggt agaattaaat
    13861 taaaaggaga taaaaatgga tttaaaataa ataaacaagc tatagaagaa gtaatccaag
    13921 gtactttttt aggaaaagat ttaaaagaat ttacctatgt tggaatggta gatggggtat
    13981 ttataaataa agaagaattt aagggattgt ttgaagataa tttttttagt gtagataaat
    14041 tttttggaca actagttaaa gaagtaaagg aatattatgg ggtgaattaa tatgaaggtt
    14101 ttgaaattag atttatttca agaaactgca tgctacaaaa aaccatttgc tatgaagatt
    14161 acagagacat atccactgcc tccatattct acaataaatg gattaattca caaaatatta
    14221 aatgctacag aatatatacc atttaatata agtgtacagg gaacatatga aagtatattt
    14281 aataattacc agacaacata tttttataaa aaagatagta ttacatctat gccaatgaat
    14341 agtcatatgc tattgaatgt aaatttgata attcatatag gtggggattt tgatttattg
    14401 gaagaaatat atgatagttt attaaattat gacgagcact tatcattagg tagaaaagaa
    14461 gatttagtaa gaattaatga tattagattt gtagaagtca ataaatttga agtagatgag
    14521 gatatacaat tagatgatta tgaaaattat aagttatcag aatgtaatat aagaatgcct
    14581 atatatatac caaaaacaag tttacaagat acagatatag atggtataag ttacagactc
    14641 aataattact atgataataa tgctgtggaa gataaaaaaa gggtttggaa taaggtagat
    14701 agttattatg ttgaggatgg aaatactata tcaattggag atatattatt agataatgaa
    14761 ggagatttat tatattttaa taatataaat taggagggag attatgttat atgctaaatc
    14821 taatccagtg gaaacactta gagaacatac tgatgaactt ttaaaacaaa tgaatgtatt
    14881 aagagaaagt tatggaaaaa atataaatag cttagatttt ctagaagagg agatattttg
    14941 gcaattactt gaccttgtta tagaatttca tgatattgga aaggcatttt caccgtttca
    15001 agagttaata aaaagcagaa tggatactaa aataaatgaa cctaaaatag taactcattt
    15061 agaaaataat gtaggccata attatctttc tcctgcattt attgattata gttatataga
    15121 caggaaaaaa aataaagaac ttagagcagt attaaatcaa gttattgtat atcatcatga
    15181 aagagatatc tttatagata aagattttaa aaatttaata caaaaaatat tagatgaaga
    15241 tttaataaat aaagtttatg aactacagca tgaatttaaa gttagatatc caataaaaac
    15301 agaaagattg agtaaagtat atctacaaag tgtagaaaaa agaatagata aaaatcacaa
    15361 gtactataat ttatatatta tgttaaaagg aatactacat agactagacc atagtgcttc
    15421 tgctcatgaa gttgtggaat gcaataatgt tataaatata ggagaacaga cagaaaatta
    15481 tttaatgaaa gagtttggta gtttgagaga ggctcaatca tttgctaaat ctaatagaaa
    15541 taagaatata atactgattg catctacagg aatgggaaaa acagaaactg ccttaatttg
    15601 gatagataaa gacaaggcat tttttacact tccattaaga gtaagtataa atgcattatt
    15661 tgatagagca aaaaatatag ttggagttgg agaatcaaat gatacattct taggtttgtt
    15721 acattcaaca gcaatagatt atctagaaga aagtaatcaa gaaaattcaa gtgagattgt
    15781 agatttagca aagttattat cttgcaaact gacattttct acaatagacc aaatatttaa
    15841 atttcctttt ttgtatagag ggtatgaaaa agtgtactca acattagcat attcaaaagt
    15901 agtaatagat gagatacaag catattcacc agaaatagca gctgtattgg taaaaggtat
    15961 agaaatgata cataagatag gtggcagatt tatgataatg acagctacta tgccaaccat
    16021 atatatagat gaattaaaaa aaagaggtgt aatgaatagt aacttagctg aattgacatg
    16081 taatacagaa aaaataagac attgtgtttc tattgtagaa aattcaatag atgaaaactt
    16141 aggtaaaata atacaaagtg gaatgaataa aaaagttctt gtaatagtaa atacagttaa
    16201 aagtgctgta gaaaaatatg agttaataga agaaatagtt aaaccaaaag gaatagatgt
    16261 caacttaaat cttttacatt ctatgtatat acaagaagat agagcaaaat tagaaaaata
    16321 tataaaagaa tttgccaata gtgatagaaa tggaatttgg attacaacac aattagtaga
    16381 ggcatctctt gatattgatt ttgatgagct tcatacagaa aattcaacac ttgacagtct
    16441 atttcaacga tttggtagat gttatagaag tcgtgagtat gaagaaaata gcccaaatat
    16501 atttatatat acagaaaaag ctacaggaat aggtagtatt tatgataagg atattgtaga
    16561 aaaaggactt gagctactga aaacttttat aaatggaaaa gaatgtgtga agatgaaaga
    16621 aaaatataag gtagaaatgg ttaagatact atactctaaa gaaagtctag aaggtacagc
    16681 ttttgaaaag agatttacca gtgctttaaa tattttagat actataacgc catatagttt
    16741 aggttctaaa gatgcacaaa atatacttag aaatattgaa ggatatacag taattccaga
    16801 ggatatatat aataaaattg aagaaacttt aatcaaagat tatgaagagt tgggacaaga
    16861 gcttataaat gcatatagta atgatgatag acaattgata aataaaataa agtctaagag
    16921 aaaaaaagca agaagagaga taattaaaaa aactgtaaat ttaccaatat ataaagctaa
    16981 acaaaatgta attgacatac aggtgaaagg tcttgaagat ttaaaaatac ttttatataa
    17041 atatgatata tacgaaaata agcatacaaa acagatattt ggtaaaggtg tgcttataag
    17101 taatgaaata gaccaattta tttgattttt atattaacaa tgtggctaaa atttactaaa
    17161 gaaggtgatt ttgtgccaat agatttagaa gtattaaaag ttcaaggtgt aaaaataaat
    17221 tattattatg tatgtaaaag aaaactatgg ctattttcta aaggaataac catggaacaa
    17281 aatagtagta gagtattgtc tgggaagata gtacatgaag attcatataa aagaatgaaa
    17341 aataaagaaa tattgattga tgatatcttg aagctagata taataaagga tgagtatgta
    17401 aaagaagtaa aaataagttc aaagatgaaa gaagcagatg aaatgcagtt atactattac
    17461 ttatactatt taaagaatag tatgggtata gagaaaaaag gaactataaa ttatgttaag
    17521 gaaaagaaac aagaagaatt gatattgaca gaagaaaaag aaagaattat tgaaaacaca
    17581 cttataaata taaatgaaat aaatatgcag ttatctcctt ccaaaattga gaaaaaacat
    17641 tattgtacaa aatgtgctta ttatgaattt tgttttgtga aggaggagta acaatgtata
    17701 aagactatta tattataagt aatggggata taaaaaggaa agaaaatacg atttactatt
    17761 acaatttaga aggtgagaaa aaaatattac cagtagaaca agttgatgat attcatatat
    17821 atggagaagt agatttaaac acaaaactta taaattacat aagtaaatat ggggtgatgc
    17881 ttcatttcta caattactat ggatattatt caggtacata ttatccaagg aagaaaaatg
    17941 tatcaggatt cagtttagta tgtcaatcag cctgctattt agataaaaat gaaagattat
    18001 acttagcaaa atcctttgtg gaaagtgcat cataccatat tttaagaaat atgagatatt
    18061 acaaagttga tgaaagttta attgatacta taaaggatga actaaatgat ttgaatgatg
    18121 tcaaagaaat atcagaactt atgggtaaag aaggcagaat aagaaaaaca tactataaat
    18181 catttaatca aatattaaaa gatgattttg aattttataa aagagaaaaa agacctccca
    18241 aagacccagt aaatgctctt atgtcttttg gaaatagcat aatgtatacg aatgttttaa
    18301 gtgagatata taagacacaa cttgacccta caataagctt tttacatgaa ccatcaacaa
    18361 agagattttc tttaagttta gatattgcag aaatttttaa gccaattata gttgacacaa
    18421 taatttttag cctgattaat aataaaagaa ttaataagaa tgattttgaa tatcaagaca
    18481 aaatttgtta tttaagtgaa aaaggaaaga agaaattttt gcaagaattt gaaaataaga
    18541 tgcagacaac tataaaacat agaaatctaa atagaaaagt ttcatataga atgtttataa
    18601 ggttagagtg ttataaatta attaaacatt ttataaatga tgaaaggtac aaagttttaa
    18661 aggtgtggtg gtaagtatgt ttgttattgt tacttatgat attgttgaag caaggtcgtt
    18721 aaatagaatt agaaggatac ttagaaaata tttgacttgg acacaaaatt ctgtttttga
    18781 aggcaatatt actgaaggaa agttacataa atgtatttct gaaatagaaa atattattga
    18841 taatagcgag gattcaatct atgtttatga gataaaaaat cctaattcaa ttaaaaagaa
    18901 atgttatggg attgataagt attctgatga aatgtttata taggtttgca gtgagcgata
    18961 tttatgctaa aataggtgtt aacagttgga atataaggga ttgaaggtgt atgataactg
    19021 ttatcaattg cactactgct cgctcactgc aaattttgat gtttttattg aattataatt
    19081 gcttgattga agtgttttca atgtattcaa atatacctat tttggggttt tatattaact
    19141 aagtggtatg taaattggaa aacttgtcaa aaatagcatc aaagcattta tagttttata
    19201 ttaactaagt ggtatgtaaa tggggctttt ggggacatga gtgttacaga tgcactaagt
    19261 tttatattaa ctaagtggta tgtaaatagc cccctaatgc tggaacagtg aggacacaca
    19321 aacgttttat attaactaag tggtatgtaa atgaactttt aaaagattat gctaggaaaa
    19381 ttcatgttgc tggttttata ttaactaagt ggtatgtaaa taagccaaaa gctacgaatt
    19441 tgaactaaaa tgcgtgggtt ttatattaac taagtggtat gtaaattgcc tagggaaccc
    19501 ctccagcccc taaccatgca acagttttat attaactaag tggtatgtaa ataacaagaa
    19561 aaaccaacaa caaaaccaac aacaaaaagg ttttatatta actaagtggt atgtaaatct
    19621 ttccataaaa taccccctac ttcattttta tttagtttta tattaactaa gtggtatgta
    19681 aataagacca agccacttcc gcaattgcat cttctaacat gttttatatt aactaagtgg
    19741 tatgtaaata gtgtattttt atcattctat ctactatacc aaaaaagttt tatattaact
    19801 aagtggtatg taaatgcata cctgtaacct gcatcatttt gtatctatct tgttttatat
    19861 taactaagtg gtatgtaaat aaaagattgt aatgagtacg agacaagatt tattgtgttt
    19921 tatattaact aagtggtatg taaattatat aaattttctt tttcttctat ttctaagttc
    19981 agttttatat taactaagtg gtatgtaaat gttgtatagc tagtacttcc tgctttaaat
    20041 ccttttcgtt ttatattaac taagtggtat gtaaataaga caaggttctt cttttaagtg
    20101 gcaagctata aaagttttat attaactaag tggtatgtaa atcgagtaaa ataacaatta
    20161 tctggaatgt gagaagttgt tttatattaa ctaagtggta tgtaaattac acataattac
    20221 aacccagttt actttttgct acacgtttta tattaactaa gtggtatgta aattatgaat
    20281 atattacata atcataaaga tttacaaatg gttttatatt aactaagtgg tatgtaaatt
    20341 ctctaaatcc atctataacg ttaccagcaa aatcaatttt atattaacta agtggtatgt
    20401 aaataagaac ttttcatgaa cgtggaaaat attgagttca gttttatatt aactaagtgg
    20461 tatgtaaatt tgtcatttac gactaccatt tctctagcat ttatatgttt tatattaact
    20521 aagtggtatg taaatgggaa aatatgggaa aagttaacta atataatgca aagttttata
    20581 ttaactaagt ggtatgtaaa tgaaattttt agtgctattg caactactct tgtttgtgtt
    20641 ttatattaac taagtggtat gtaaatgcat aaccaaaaac ttcaaaatca agacctcgaa
    20701 tttgttttat attaactaag tggtatgtaa attgcgcaat aacatgctga aaactgcaat
    20761 ttcgaagtgt tttatattaa ctaagtggta tgtaaatagg ataaagaaaa gactcacaca
    20821 aggcacagtg tcaggtttta tatcaactaa gggtagataa gtagaatatt agcaatatca
    20881 acgagtattt agaaacttat tttatattaa taaagcagta tataaaattg tagaatcaac
    20941 aatagcatat actaaaacat ccaccttata ttaactaaat catatctaaa taaaatacac
    21001 ttacctataa acattataaa atcaatacaa aaatgaggtg aaataaaatt tatgataaag
    21061 aaattaaaca ataaagacat aaataaaatc atggaaatat gggaaaaaag tacaatcaaa
    21121 gcacatgact ttataagtaa agaatactgg caaaataact ataatactgt taaaaacgaa
    21181 tatataccta tatcagatac atttgtatat gatgatggag atgaaataaa aggatttata
    21241 agcataatag ataaaagctt tataggagct ttatttataa agcccaaata ccaaaatcta
    21301 ggtatcggag gtaaactttt agattatgca actaaaaaat ataaaagtct aagcttagca
    21361 gtatataaag ataataaaaa agcagttgtg ttttataata aaaaaggttt taatatagta
    21421 aaagaacaag taaatgaaga ttcaggattt aaagagtaca taatggaata tagtaaataa
    21481 tatgattaca ttctattaaa aggataatta atttatttgc catttgattt tttaagagta
    21541 atttttaaaa tagactatat gaagataaag atatttatta tagatgtaag ttaatcagaa
    21601 ttgatatagc tacaaaagag gaaaataaaa ttgtatggtg tatttcagat ttaacaaatt
    21661 tactatttaa agataataag tttgatataa tattaaagat actttcacct ataaactata
    21721 gggtatttga aagaatttta aataattatg gaatgctaat aaaggtttgt taaaatttaa
    21781 taattattag attatagaaa attgccatga aattagttca tcaagaacta gtttcatagc
    21841 aattttaatt cttataagtg tatttatttt tacagattta aaaaacttat acagtatcta
    21901 ataatgtaat cttattactt tagcctataa atatttaaat cttaaaatgt tctctttgag
    21961 ataagcttat ttcagagtca caatttccac aacagtaaga tgttgagaca tctttaaatt
    22021 tttcagtatt ctcatcaaag ttcatttttt tctttgcaat aattcctacc ttagttaaat
    22081 tagaaccaca attattacag ttttgaattt tgcataggtt atatagttta tcaagtgtaa
    22141 tatcttctaa taattcatca caattacaac atctgataga agaaacttca ctacacattt
    22201 caataggttc agcttcttta gaagaaaatt tatatgttat gtcatttgat actttataac
    22261 ctgtatcaaa tatattagaa ttacaacttg gacataagta ctttggaaga tatatatctt
    22321 ttttttcaaa agtatcacta ctaatattac agtttaattc atctaaaatt ggtctttcat
    22381 ctaggttatt acctttattt aagcttagaa gataattata aattttttta tcttcattct
    22441 gctttgatgt atctaacaaa tgctccatta tattagtgta ttttttgttt tttgaaggca
    22501 tgtttaaatc cagataattg ttttcaatag caaagcatac tatattgaaa tagttatatt
    22561 taactgcaaa aaataataac atttcatcaa atactttatc tattattttg tcagaaatac
    22621 ttatccaaaa atctggggac tctaagtaaa ctttcctact aagttcacct aactcttcat
    22681 ctatattatt tatattattt tcattaactt tcatatcatc acttcctttt aaatatcttg
    22741 tgtataaact atttgttact attttttata taaaataaaa tcttatataa aaatatatca
    22801 tattataatt tacaagtata gtctaaatag agctgttttt aagcaaagtt ttataaatga
    22861 ctattaaaat ataaagtaac agtataaagt ttacttataa attaaatgta aacctaaata
    22921 attataatag ttgacaaaaa aacgtcttta ttttatacta aaacaaagct ttaatagaag
    22981 ctttgtatat gtacatataa actaaatgaa ataagacata tgaagggaat tataaaaatg
    23041 aaaaatacta aagtaaatat tcaagattta actaaaatgt caatatgtgt agcattattg
    23101 tgtatatcat cttacatata tataccattg ccatttactc cagcaggagt aacagcacaa
    23161 acaataatga taaatttaat agctttgatt ttaacaccaa gacaagcatt tagtacagtt
    23221 ggtgtatata taatgatagg tttaattggg attccagtat ttggtggagg tacatctggt
    23281 attggaaagt tgttaagccc aacaggtggt ttttattttg ggtttttgtt tgcagcacta
    23341 attattagtt tattaaaagg acgaaacaat gatattaaga gatatatact aataacaatt
    23401 tttgttggaa tgcctattat atattttatg ggaacagtat ttatgtgcta ttttaatcaa
    23461 atgacagtag aagcagcact ttttgcagca gtagtaccat ttttaattgg agatacaata
    23521 aagtcagtta ttgcatcttt tttaggcact aaactgaaca atgtactcag aagaaatcta
    23581 tgataaatct ataatataag gaagggtgta atgtatgaag gaagttttta tattaggagg
    23641 attgagaagt catataggtc taaaaaatgg aatttttcaa tttgttcaac ctgaattact
    23701 aggagcaagt gttttaaaag atttaattaa aaagtatgaa attgacaaaa ttgatgagat
    23761 tatatgtgga aatgcagttg ggacaggagg gaatatagct agattaatga ctttaacagc
    23821 aggagtgtca aatgaagtac ctgcttttac tgtggatatg cagtgtgctt ctgctatgat
    23881 gagtatagac atagcttttt caaaggttaa atctggtcag tgtgatttaa ttattgcagg
    23941 tggttttgaa agtagttctc tacaaccaat gcgcacatat cataagaatg ataagcgata
    24001 tgatacaaat aatccaaatt atacagttgc tcaattttct cctgatgata atagccaaaa
    24061 tagtatgctc gaaggggcgg aaagagtagc agagctatat caaattgaga aagcagactt
    24121 ggatttttgg gtaaaggaaa gtcataaaag agcaaaagaa gcaagagaag aaaaaatact
    24181 tgaggatatt atatctccta taaataatag tacctatgat gaaggtatac gtgataagat
    24241 gagtcaaagg ttattagata ggatgccatc aattttagga aaagaaacta ttacaaatgc
    24301 agcaaattca tgtcttatta atgatggagc ttcatttatt ataatatgtt ctaagaagta
    24361 tttagaacat gtaaaaaaga agcctaaagc aaaaattatt aatacatgca caataggaac
    24421 agatgcaacc ttaagtccaa catcagcgat acaagcaatg gataaacttt tagagataga
    24481 aagtcttaat tatttagatg tatctgctgt tgaatttaat gaagcatttg cagttataga
    24541 tgtgttgttt caaagaaagt atccagagtt aatagataga tataatatat ttggtggagc
    24601 tttagcgtat ggacatccat atggtgcttc aggtgcaatt attgcattac atcttttaaa
    24661 agcattggaa aagactaagg gtagatatgg aatttgctct atagctgcag ctggtggtct
    24721 aggttcagct ttactgcttg aaagggtgta gattatgaac tattatgaac ttttaagaat
    24781 aaaaaaagag aggcaaaaaa ataaaaattt tttaattata gatggagaaa aatatactta
    24841 tgaaaatata ttgagttata gtgaggaact aggaaagcaa atttctttag gtgaaaatat
    24901 cccaatttta atatattcta aaaatataat gtttcagttg attagttttt ttgctattaa
    24961 ttattcaaaa aatattccta ttatttgtca ttataatctt tctaaaaaag tattagatga
    25021 tattttatta aaaaataata tttcaatcat tatatctgat gaatctatgg acgttattga
    25081 tttatatgat gataacaata atgaagtagc aaaaaaagtt aatttttcta tttttaatcc
    25141 taaatttaat atatatatgt atcaatataa gaagcttata aattatttag ataaaagtat
    25201 ttgtatggga gctttatctt caggttctac aagtgttcca aaggtattat atagaacata
    25261 tgagagttgg gctggatttt ttcctataca aaatggtatt tttaatatct ctggggaatc
    25321 aatcttgttt gttaatggaa cacttagttt tacagggaat ctaaattcta taatgtcagt
    25381 attatatgaa ggaggtagta ttgtaataag ttcaggtctt aattgtaaat catggataag
    25441 gacaataaaa caatataatg taactaacat ataccttata cctacaaaac ttcaactttt
    25501 ggttaaacat ttaaaagaac cagtactcaa agttgtaagt atttttacag ggtctcaatt
    25561 attatttgaa gatactgcaa gaaatctaaa aaaatatatg ccaaagtctg aaattatttt
    25621 atactatggg gcaagtgaat taaattatat tacatattta tgctatgatg aactaattga
    25681 aaaacctcta agtgtaggca gaccatttcc aggaatagat atatatatta gagaaggaaa
    25741 aatttttgtg aatacagaat atgcagtata taatgcaacc aaaccttatt ctgtcaatga
    25801 tattggatat tatgataatg atggatactt aatatttgaa ggaagaagtg atgacattat
    25861 aaatattgga ggatttaaag ttagttctac taagattgaa aatgaagtta aaaaaattcc
    25921 tcaaattgaa gatgcaattg tattgccgta ctcagacact ataagaggaa atcaaattgt
    25981 attatttgta ataactatag acaaaattac gaagaaagat ttgttgatta aaatgaaaga
    26041 taatctaatg aaaaatgaaa tcccaaagaa aattatcttt ttaaattcat ttccatatac
    26101 ctcttctgaa aagatagata gattagcatt attaaaaatg ttataagtat aatatttagt
    26161 aattttagtg aaccaatgta ttgataaaaa catattgtat atagtaaagg aggcttacaa
    26221 tatgtcaaat caatacgata taactgttat tgggggagac ctgcgacaag tgtacatggt
    26281 aaaaaaacta attaataaag ggtattctgt agtcacttat gggatatcaa atgaaattat
    26341 aaatggaatc gttggaaaat caacttcact agctgaagca ctatccaaaa gttccattat
    26401 tttatgtcca attccattta caaagaatca agttaatatt gaaaatacgg atgattgtct
    26461 tgatgctact attgataact tgctaattaa tttatctcct aatcaaatat tatttggagg
    26521 taacatacca actaaagttt gtaaattttg cgagcaacac tctattcaga tttatgattt
    26581 tatgaaaatg aatgatgttg ctattttaaa tgcagttgct acagctgaag gggctatagc
    26641 agaagctatt aaaagaagta taatcaatat acatcaaagt aactgtttag tattaggtta
    26701 tggaagatgt gcacaaatac ttgcaaaaaa attatacgct ttggatgcaa atgtatgtgt
    26761 tggcgcaaga aataatgatg caagaagtac ggctaatgca tttggatatt ccagtatttc
    26821 tttaagtcaa cttgatgaaa aacttttaca atttgattat atttttaaca ccataccaga
    26881 gtgtatttta acgaaagaaa ggttagaaaa agtatcacaa gaagtaacta ttatagatat
    26941 agcttcttct cctggaggag tagattattc tgttgttaaa gaagcaggga ttaatgcgac
    27001 tctttgcctt gggcttcctg gtaaatattc accaaagaca tctggtgaaa ttcttgttaa
    27061 cgctatagaa aatattataa atgaaagaag ggattagaaa tgagacttga aggacttaca
    27121 attggagtag gatttactgg ttcgttttgt acttatgata aaatatttat agagttagag
    27181 aatttggtta aagaaggagc taatgtacac actatatttt cagatgtatc acaaaatatc
    27241 gattgtagat ttggaaattc tgaagagttt atgaaaaaag catatgaact tacaggaaat
    27301 aaacctatag ttacgattga agaggcagag ccatttggac ctaaaggaat tgctgatatt
    27361 ataataatag ctccttgtac tggaaatact gctgcaaaat tagcaaatgg tattacagat
    27421 tcaccagtat taatggcagc aaaaggtcat cttcgtaatg ataaaccact agtaatatca
    27481 atatcaacga atgatgctct aagctttaat ttcaaaaata ttggcattct ccttaattct
    27541 aaaaatatat attttgtacc ttttggtcaa gataattgca aagcaaagcc taattctatg
    27601 attgcacata ctgagctaat aattccaact atagaacttg ctctagagaa caaacagcta
    27661 cagcctgtta taaaaagtcc acatcaatag aattggttct tataatatta tgtattagat
    27721 acaatactag caaagaggct gtctcaaaat agagagaagc ctctttttct tgttgaaatg
    27781 atgaaaatat atttaatttc atacaaaaaa atgcctcatg gactaaaaag tctattttga
    27841 gctaatctcc gtaatttttg ctatattaaa attatttact taatccaatt tttaaattag
    27901 aatttatatc gttttgactc ttcaaatatc aatctaactg ttgttgatac aaaagaagag
    27961 gacataatta aaacaaatac tgatagtcct ctaataaaca aattatctac ataataagtt
    28021 actattccaa tacctccaat cgttaaaatt acacttataa tcaaagaaaa aacgctaatt
    28081 gtttttaatt tttccatgct tatcctcctt cttataaact tcaaatttat ctatataata
    28141 ttaaatatat tttatttcat attatataaa aatcatgaat atatattttt ttaattatac
    28201 tatatgttgt aaatgtttgt acatttaact atatttactt taacttgtta attaagtttt
    28261 aattttcatt ttcaaggatt tttattttta aacttgatag agtatcatat taaaaattct
    28321 ttttataaag ttttatttgc aaaaaataca aaaatataaa cgttaaaaaa ataacgttat
    28381 ccttaagttt ttagatgatt tcattagtga tttgcgtaaa aaataaagtg atatctagtt
    28441 aaattaagta tttgtaaagc tagatattat tagtagaaat gatgttatat tagataaaaa
    28501 ataaaatgtt aaaaaaataa cttgaaaata ggaaaagtaa atgctataat gttaataaat
    28561 taacataata aataaaaaac tatctcagga ggttgttaaa atggctcata aagaacaagt
    28621 aataatagaa aataaaaaag aaaatgaagt tatgtcagtt ggtttagata ctgtaaataa
    28681 cgttgaaagc ttagttaaaa aactagcaaa aatcagagaa gctcaaaaaa tatttgctac
    28741 atatagtcaa gagcaggtag ataaaatttt tttagcagca tctttggcag ctaataagca
    28801 aagagttcct ctagctataa tggcacaaaa agaaactggt atgggaattg ctgaagataa
    28861 ggttataaag aatcattatg cctcagagta tatatataat gcatataaag aaactaaaac
    28921 ttgtggtgtt atagagaaag acgaagcatt tggtatgact aaaattgctg aaccaatagg
    28981 tgttattgca gcagttgtac ctacaactaa tccaacttct actgctatct ttaaagcact
    29041 tttagcttta aaaactagaa atggaataat tttctctcca catccaagag caaaaaattc
    29101 tactatagag gctgcaaaag ttgttcttga ggctgctgtt ttagctggag ctcctgaagg
    29161 tataatagga tggatagatg agccatcttt agaattaact acaactgtta tgaaagaagt
    29221 ggatttgacc cttgctacag gaggtcctgg aatggttaaa tcagcatatt catctggaaa
    29281 accagctatt ggagttggtg caggtaatac tccagcaata attgatgata gtgcagatat
    29341 aaaaactgct gtaaactcaa ttcttgtatc taagactttt gacaatggta tgatatgtgc
    29401 ttctgaacaa tcggttatag tattagaaaa tatatacaat gaagtcaaaa aagaatttaa
    29461 agagcgtggt gcttatttat tagataaaga tgaaacagaa aaaataagaa atataatttt
    29521 agtaaatgga ggattaaatt ctaaaatagt tgggcaaaca gcttgtacta tagcaaaact
    29581 tgcaggcttt gaagtcccag tagatactaa ggttttaata ggtgaagtag aatcagttga
    29641 aatagaagaa gcttttgctc atgagaaact ttcaccagta cttgcaatgt acaaggcaag
    29701 tgattttgat gatgcagtta gaaaagcaga aaaattagta gaagatggtg gatttgggca
    29761 tacatcttca ttatatattg atgatgtaaa tcaaagagaa aaacttgata agtttacttc
    29821 agccatgaaa acttgtagaa ttttaattaa tactccttct tctcaaggtg gtatagggga
    29881 cttatataat tttaaactag ctccttctct tactttagga tgtgggtctt ggggtggaaa
    29941 ttcagtatct gaaaatgtag gagttaagca tttacttaat attaaaacag tagctgagag
    30001 gagagaaaat atgctttggt ttagagcacc agaaaaagtt tatttcaaaa aaggttgttt
    30061 aggagtagca ttaaaagaac ttaaagatgt aatgaataag aagagagctt ttattgtaac
    30121 agatacattc ctttacaata atggatatac taaagcagtt actgatttat tagatgaaat
    30181 gaatattaag tacactacat tctttgaagt agaaccagac ccaactttgg aatgtgctaa
    30241 gataggcgct aaagctatga gagaatttaa tccagatgta ataatatcta taggtggagg
    30301 aagtgcaatg gatgcaggaa agataatgtg gacattgtat gagcatccag atgtagattt
    30361 ccaagaccta gctatgagat ttatggatat aagaaaaagg gtatatacat tccctaaaat
    30421 gggtgaaaaa gctaattttg tagctatacc aacatcagca ggtactggtt cagaagtaac
    30481 accatttgct gttataactg accaagatac aggagtaaaa tatccattag cagattatga
    30541 actgatgcca aatatggcta tagttgattc tgatatgatg atgaatatgc caaaaagctt
    30601 aacatctgct tctggtatag atgctttaac tcatgcatta gaagcatatg tatctatgct
    30661 tgcaaccgat tatacaaatg gattagcttt acaagctatt aagagtatat ttgaatatct
    30721 tccacgtgca tatgataatg gtgcaaaaga cccagaagct agagaaaaaa tggcaaatgc
    30781 ttctacaatg gcaggtatgg cttttgcaaa tgcatttttg ggtgtttgtc actctatggc
    30841 tcataaatta ggtgctttcc accatgtacc acatggtgtt gcaaatgctc ttttgataac
    30901 agaagttatg aaatttaatt cttcagatgc accaaagaaa atgggagcat tctctcaata
    30961 taaatatcca gaagcattaa agagatatgc tgaaatagct tcatttttag gattaaaagg
    31021 aaattctgat gaagagaaat tccaaagttt attggtagct attgaagatt taaaacttaa
    31081 agttggtatt cctaaatcta taaaagagtt tggcgttgaa gaatctaagt ttatggattc
    31141 aatagatgaa atggtaattc aagcatttga tgaccaatgt acaggagcaa atccaagata
    31201 tccacttatg aatgaaataa aagatatgta tttaaattca tattatggaa gataagtttg
    31261 ctataaaata gataaaataa aaactcttat acataaaaca aagttttatt gtataagagt
    31321 ttttttgttt gagaaaatgg atagttttta ttctttaatt taaaattcaa ttaaatagtg
    31381 ttattataat aataaaagaa tgtttttatg gttattatgt tgattttatg tgtaacattt
    31441 aagaatagtt atatacaata taaatgatga attggtataa aaaggatata ttatctatat
    31501 gaagtattga ctaattaggg gaggagtcga atgacaggga gaaataaaag ttttacatta
    31561 attacaattc tttttttaac atcattattt ttgacaatgg ggtatatcta tatagaagat
    31621 acaaaacatc ttcttatgtc agaggcaaaa atacatataa aagaagttgc agtacaaggc
    31681 tctcaactag cacaaagaca aattgaaaaa gatttagatg ttttaaatat tttttctaac
    31741 tattatgctt caaatccaga tatacctaat gaggaaaaaa tgaaaaatct tttagatgaa
    31801 atggaaaatc aaaaatttta cactatggca atagttgata taaatggtaa tgctgaaaat
    31861 accaaaggtg ataagttttc agtgaaagat agagaatttt tcaaaaactc aattaaaggt
    31921 aagaagtatg tttcaagtcc atatgttgat gaagtaaata agtctataaa gaagattgct
    31981 atttcagtac cattattaaa taatgataaa gtagttggag ttttatattg tacttacaat
    32041 atcaatactc tgatgaaact tattaatata tctttttatg aaaataatag tatatcttat
    32101 gttgtaaaaa ataatggtac aattatcctt catccacaag gggatagcct atcaaaaaat
    32161 atttataaat tgttaaaaca ggataatgat attcaagaag taaatagatt aaaaaaagaa
    32221 ttgcaagaaa ataaaacagg tgcaactgta ttaaatatgt tggaagaaag aagatattta
    32281 ggatatgcca ctatggataa tgggaatagt gaaaataatt atataaaaga ctggaattta
    32341 attttttcaa ttccagaaac tgttgtattt agtaattcaa aacaaataat caacagagct
    32401 gtatatgcag tgttatctat tgtattaata tttattgcaa ttatttttta tataatttat
    32461 ataaaaaaat ctaatgaaaa agaaatatta agtttggctt atgaagataa agttacatat
    32521 ataggaaatc aaaataaatt ttatagagaa tgtagtaagt atcttttaga taaaccatct
    32581 ttaaattata ttatagtata ttttgatatt aataacttta agatgattaa tgatactttt
    32641 ggatatgaat ttggtgacaa tttattaatt acaatagcaa aagctttaaa agaagaatta
    32701 acagaaggtg aggtatatgc acgactttca agtgattatt ttgcaatttt ctgtgattat
    32761 aaaaatggaa gaaataaaat tataagaaaa cttgataata tacgaagtaa tattgaaagt
    32821 aatttgagta tagtctttga aatttctctg tgtgtgggta tttattttgt tgaagaaggt
    32881 gaagtagata ttcaaaaggc tgtaaataaa gcaaatatgg ctaggtctgt tgctaaaggt
    32941 aaaaatataa attatgctat ttataatgaa gatgttagga ataagcttag tgaggaatca
    33001 atgattttag atgatataaa aatagcattg gtaaaaaatc aatttgaagt gtattatcaa
    33061 cctaagtttt cacttgtaac tggagaaatg atagggagtg aagcactaat aagatggaat
    33121 catccagaac atggttttat aagtcccgca gtatttattc caatagcaga gaaaagtaag
    33181 ttgattttaa aaattgggag atttgtattt gaaagggttt gcaatgattt atatgaatgg
    33241 aaaaagcaag gtaaaaagat agttccagtt tcagtaaatt tatctagggt cgagttgtat
    33301 caaccagata ttgtaaaatt tatcaataaa acaataaaaa tgtataattt aagttcagat
    33361 ttcattgaaa tagagataac agaaactgtg gctattaatg agttaaatat tttaaagaat
    33421 gttttaaatg agttgaggac gtatggattt tctatttcta tggatgactt tggtacagga
    33481 tattcttcta ttagttgttt aagagatatg ccaattgata tattgaagct agataagtct
    33541 tttcttggtg gcattgaaca tgatgagaga agtcgcaata tagcaaaatc aatagtgtct
    33601 ctagcaaaat cactagattt agttgtaatt atagaaggtg ttgagagtaa agaacaagct
    33661 gagttaatga aacaatttgg atgtgattta gttcaaggat tttattttgc acgaccaatg
    33721 ccagctaaga attttttaga tttactttaa aacaaaattt gatttttata taaagcacta
    33781 ttatgaatgc ttgattttaa taaatcattg ctaaataatt agtgtttttt tattttatca
    33841 atgtattgtc taatataaag caaaaaataa ttgtatttta taaaaattat attaaaaata
    33901 aatttatttt gctaataaac atgttattaa caaaagaata gtactataat gtatagatga
    33961 taaaaacttt aataaaaatt tagtgtatag gagttgttta agtatgatag atataagtat
    34021 tgatgacaaa cttaaggaaa gatggcctaa tgctaagctg ggttgcattc aagcaaaagt
    34081 agcagtaaat aaaagctcag aaaaattaat taatgaaata aatgagtttt gtgatactat
    34141 aaatcaaagt ctaaaagttg aagacattac gaaactagat aaaattaaag atgcaagaaa
    34201 tgcttataaa gagcttggaa aaaatccaag tagatataga acatcttcag aagcattggt
    34261 tagaagaatt attcaaggga agggtcttta tacaataaat aatatagtag aaataaacaa
    34321 tttaatatca ataaaatcat tatatccagt aggtacatat aatgtaagca aattacattc
    34381 accagtatgt tttactgtag gagatgaagg agaacagtat aagggtattg ggaaagaatt
    34441 aataaatata gaaaatcttc ctatattatc tgattcagtg ggtaaatttg ggagtccaac
    34501 tagtgattct gaaagagcaa tgataacaga agatgcaaat gaaatattaa tttgtatatt
    34561 ttcttttagt caagaatctg atattgaaga atattttgga tatgctaagg aattacttaa
    34621 agaatatgca gatggaaaag atatagaaac taaaataatt aaatagaatc tatataacaa
    34681 cgttatgtta agctaaaatt caatataaaa ataagttaag ataaagaaac taacacaaaa
    34741 ttagtttctt ttttaaaata gtagtttagt gttacaaaaa tagatagata gtcccacgat
    34801 tattaaaagt atggtaatat attaatatag cagagattgt gtttaaggga ttttgaaagg
    34861 ggggatttat aataatcatt ttatctaaaa gataaaatgg ttttatagaa ataactatat
    34921 atttaaaaat ataaataatg atacagtaat ttgggtatat aaaataaggc atacatggtt
    34981 ttgtttaaaa accaataagg tacataggta attacaatgt aaggaaggat ttaattatga
    35041 ttgatggaaa agaggtaaaa caagaaagtg gacaaaaaaa tctaaaattt aagatagcta
    35101 tagtagtagg tgttttgttt gtagcttata taggaatggc aatctttttt agaaatcatt
    35161 tttactttgg aacgactatt aatggcgtaa aggcttcagg aaaaacagtt gagcaagtaa
    35221 atgatttgtt aacatctagt actaattcct atactttaaa cttagaggaa agaaacaata
    35281 agaaagaaca aataaaagca aaagatattg atttaaaatt tacaccagat gataaagttc
    35341 aaaagataaa agatagtcag agcgctattg gatggattgg tggaatattt aagtctaaag
    35401 agtataataa tatgataact ctttcatata ataaagattt actagaaaaa aggtttaatg
    35461 ctttatcttg ttttgatagt aaaaatgttg tagaacctaa gagtgcttat cctaagtatg
    35521 atagcactaa aaacgcttat gttatagtac cagaggtact tggaaacaaa gtgaaaaaag
    35581 atgattttta taagttagta caaaactcaa ttaattctgg gaatacttct atttctctgg
    35641 atgaaagtaa agtttatgaa gcaccaaaca acacaaagga ttcagaaaag ttgaaacaag
    35701 ctattaagac attagataag tatgttggtg tagtcgttac atatgatttt agtgaccgta
    35761 aggaaacttt agatggttct gaaattaata aatggttaaa agtagactca gaaaagaatt
    35821 atgacataac ttttgataat gatgctatgg tagaatatac aagaggttta agtaaaaaat
    35881 acagtacttt tggtgactca agaccattta aaactgccac aggtaaagat attacaattt
    35941 caggtggaat ttatggttgg ttgatagata aaaagaaaga agctgaagca ttagttgatg
    36001 ttgtaaaagc tggtaaaaat gttacaagag aacctattta catacaaaaa gctgtatctc
    36061 gtaataaaga tgatattgga aatacatatg tagagattag tctttctggc caacatatgt
    36121 ggttctttaa aaatggagaa atgcttgtat caacagacgt tgtaacaggt gatttagcta
    36181 gaggatttgc tacaccatca ggtatatatc ctcttaatta taaggctaga aatgtttcat
    36241 taactggtca aggttacagt tcacctgtaa gttattggct tccgtttaat gggaacatag
    36301 gcattcatga tgctacttgg agaaattctt ttggtggaag tatatataag tcttcaggtt
    36361 cacatggatg tgtaaataca cctttttcta aggcaaagaa aatatatgaa aatatagaac
    36421 caggtacacc aattatttta tactagtaaa tgtgttgcta acagttaagc gaagtcatct
    36481 tagtttattt aggatggctt cctttttata taaagcttat tgaagtttac agaaagacta
    36541 cttaaaagga gaaatacata atgaatgaaa aattaactaa aattttagaa gaagctaaga
    36601 atgatgatga atttagaaaa gaacttataa aaacaagaga acaacgtgat gttatggatt
    36661 cattttgtaa ggttgttaca tctagaggtt atgatatgac agtaggggaa cttttttcta
    36721 tgggagaaga atatacatcc aatctactga aaagtgtaaa tggaggagca gcatatccta
    36781 ttgaagattg gagtgattgg tacgaggatt tttttataat gttgtcgaat atatagagta
    36841 actaatgata ttatctactt aagattaata cattgcctta aaataaaact attagaacta
    36901 ggtgtaagtt ttatcaatct ttaaaaatat tgatttattt ctaactagat ataaaaaaat
    36961 tagattaaaa ataaggtgac aaaaatcgat atagcttgat gatttataaa agttagataa
    37021 aatagtgcga gatatttcta aaaattcaaa aaaaacaata aacttcaatg gttagaggtt
    37081 gaaaaagaat ataaaaaact tttatatgta ataaattaaa ttaaaattat aaaaaaaata
    37141 aaataaaaat ttaaaatgtc gacataacgt taattttaaa acaaaataac gctattgaca
    37201 aactatatcg ctttaaatta taattattga aaataatggt atttaaaaac catactcatg
    37261 tcatagtcta aaagtaagtc aaaaaaggat gtaaatctag gcaagtacta ttctaaaata
    37321 tgttttatta agaaataaac gttgaaaaat attaattatt atataaaaat gctgtttata
    37381 ctttaacaat gaggtagtaa tctaattaga ataaaaaaat ctaattggtt atatacatag
    37441 taaaaaggta agagaggtga tttggatggc ttttgaaata ataaaaagca ttgttgaggc
    37501 agagcagaca gcagacagta tcaaagtaaa agctgttact gatgcagagt ctatcagagc
    37561 tgatgctgta aacaaatgtg aaagcatatt tgctgatgta aaaaaacaag caaagcttat
    37621 ggaagaaact cttattgaga aggcagtcac cgacagtaga gcagaggttg ataaaatctt
    37681 agctaatgct aaaagtgaat gtctgaaaat tgaaaaaact gctgaagaaa gaaaaagtaa
    37741 ggctattgaa gcggttattg gaaaggtagt gagataatat ggcaatagtt aatatgaaca
    37801 aaatatctat tgttggctta gaagctcaaa aaagccagat tttaaagcta cttatgaacc
    37861 gtgggtttgt tcagattgat gatagtgcct ttcttactga ggaggaggaa ttaaaaaatt
    37921 atcttgtaaa agatagtgaa gaatctgaag ttataatgct agagcagaaa atgtctcatg
    37981 taaaccaagc aattaatatt gtttcttcac tagtgaaaca aaaaaaatcc ctacttgcac
    38041 caaaaagaga gtttaacaaa attgatagtg aaaaagaagg gcaagtttat gctgaagctc
    38101 tggagttaaa caatttgcac aaggagatag gtacaataag gtctaacata aacttactta
    38161 acaacaataa aagtatgtta gaaccatggg tgaactttga tattcctctt gaaaatatgg
    38221 aaactaagta tacaaaaact atacttggaa ctgtgcccat aagcgcaaac attgatgctt
    38281 taagagtaaa attagaagat gaaataccag aaagtgttat tgggattgtc aattctgaca
    38341 agttaatgaa ctatgtttat ttaattactt taaaagaaac ttttgatgat gttttagaag
    38401 ttttaaaaga atttaatttt tcagtggttt cattaccaaa tgaagaaggt acaccgttac
    38461 aagctatcaa gaaatacaat gaaatgataa ttagacagga aaacgtttct aaggacaaaa
    38521 cagaggaaat taaaagacat gcagatagta tacacatgct tgaaaaccta tatgattttt
    38581 acactataga aagagaccaa aaaaagatta tagagagact tgtcaaaaca aaaacaacat
    38641 tctgtcttaa tggttggtta ccaagcaaaa gggcagatga attaattaaa gaaattacag
    38701 aaaagtttaa ttgttgtgtt cagactgaag aaggaagtaa agaagaaggc ttcccaattc
    38761 tgcttgaaaa caataaatta gtaacacctt ttgaaagtgt aactaacatg tacagctatc
    38821 caagtacaaa agatattgac ccaaatacaa ttttaacttt cttctttgtt gtattctttg
    38881 gaatgatgct aagtgacgcc gcatatgggt taataattgc agtagtctgt ggatttgttg
    38941 tatataaatt aaagatacaa aaaggtgaag gaaatttaat taaacttatt ggtatctgtg
    39001 gagtttcaac tactgtatgg ggtcttatat tcgggggtat tttgggggat ttaattccta
    39061 taaaagcatt aattaatcct ttagaggatg ttatgacact tatgggaatg tcgttactgt
    39121 tcggtattat ccatatatat gtaggtttgg gaataaaagc atatacatta ataagaagtg
    39181 gaaaggtaat agatgcaatc tttgacatag gtttttggta tttgtgtata acaggtgtat
    39241 gtctacttat aatacctttt gttgcagggg atataggtgt attttcagaa gtaggaaaat
    39301 atttagcaat tataggtgct ataggtcttg tacttactca aggaagaagc tttaaaggta
    39361 ttcctgttaa gctttttaaa ggattttcaa gtctctatgg tataacaagt tattttgctg
    39421 atatattatc ttatacaaga attatggcgc tttgtttaac aacaggagtt atagcacaag
    39481 ttatcaacct tttaggagct atagctggtc cgatacttgc agttgtaatt ggtgttgtag
    39541 gacacacaat aaaccttctt ataaatgcac taggtgcata tgttcataca agtaggttac
    39601 agtatgtaga atttttcaat aagttttatg aaggcggagg agttcctttt gttccgttta
    39661 agtataaaac aaaatataca agcattaata aaaaggagat gtaaatatgg aatttttaaa
    39721 cgcgttagga aatggtcaat ttttggcaat atcaggagct gctatagcag cattatttgc
    39781 aggtatgggt tctgctaaag gtacttcaat agcaggtcaa gccgcagcag gtgttgtaac
    39841 agaagaccct agtaaattcg gtcaacttct agttttacaa cttcttcctg gtacacaagg
    39901 tctgtatgga tttatcatag ctttccttat tttatcaaaa gcaggaatta ttggtggaga
    39961 tgcaatacca acatcagctc aaggtttaca acttcttatg gcaggacttc caattggttt
    40021 agttggttta gtatcaggta tagcacaagg taaagcagca gcagcaggag ttggaatagt
    40081 tgcaaaaaga cctgaagaac ttggtaaagc tataacattt gcagcaatag ttgaaacata
    40141 tgctctttta ggactacttg tttctttctt agcttacaat ggaattgcaa ttggttaatt
    40201 ataaattata attcataagt aaaaaaaatg aaaaggagga agcactccta tgggtaatga
    40261 acaaaaaatg attgacagaa ttatagctga tgccaaacaa gaagcacaag aaatattgga
    40321 taaagctaaa agtgaagcag atttaaaagt aaattcagct aatgaaaaag ctgaaaagga
    40381 aatggcttcc tatacaaagc ttgcagaggc agaagcagaa aaagcggctt ctaaggaaat
    40441 atcaggagct tatatggagg ctaaaaagca aatattatca aaaaaacaag agattttaga
    40501 agaggtaatt ttagaagcta aaaacaaact tttaaatctt aaagataatg aatatgaaga
    40561 gattatacta aacatgattg aaaaatcaaa ttgtacagat gattcagaga tagtattatc
    40621 taaaaaagat aaaaaaacat taaaagatgt gctatcaaaa aaaggcatta aagtgtctga
    40681 tgaaactaga gatattactg gaggtttcat agttaaaaaa ggtgacattg agtacaatta
    40741 ttcatttgaa gccataattg cagtagagca tgaatatatt gaacaaattg cagcagaaat
    40801 tttgtttaat taaggagggg ttaaaaaatg gcagaagaaa aaacttatcc ctatgccgtt
    40861 gcacgaataa gagtgcttga aaaacagctt cttaacagac aaatgtttat tcaaatggca
    40921 gaagccaaaa gccctgaaga ctctttaaga attatagctg aggcaggtta tgctgataca
    40981 tcaaataata atatacataa ttttgagaat attttgactc aagaattatc aaagacatat
    41041 gaaattctta aaagtctagc tcctgaagaa aaatttgttg atgtatttct ttataaaaat
    41101 gactatcaca atttaaaagt gctgattaaa gaagaaattt ctggtgtaga tggtgagaaa
    41161 tatttaattg atggaggtac aattcctctt attaagctta gagaatcttt agcaaatcgt
    41221 agttttagtg atttacctaa gataatgtca tcagctatat tagaggcatt tgatgtttat
    41281 aataagacac aaaatggcca gatggttgat attgttctag ataaagcaac ctttaccagt
    41341 atgaaagaaa ctgctaaaga aagccaaaac aaatttgtaa tagattatgt tatgaaagtt
    41401 tgtgatttaa caaatctaaa gagttttata agagtcaaaa atatgaagaa agattttgat
    41461 atgtttatga atgtgtttgt ttcaggtggc tcacttgata aggaaaaatt cttagaagct
    41521 ttttcctcag atactccagc atcatgtttt aaatctactt cttactctga tgtctgtaaa
    41581 aatggcatgg atagtggttt tactgtcttt gaaaaacttt gtgatgacta tcttatggaa
    41641 tatgttagag gagcaaaatt taagcctctt acattagaac cactaattgc atatttatat
    41701 gctaaagaat cagagataaa aacaattaga attattttga ctagtaagct taataatata
    41761 gacgcagata ctataaaaga aaggctaagg gatgcttatg tataaggtag gagtagttgg
    41821 agataaagat agcatcatgg gatttttagc tcttggaata gatatcttcc cagcctatga
    41881 tagtgacgaa attaaaaaaa gtatacataa gttggttgaa gatgaatatg cgataattta
    41941 tattacagaa caggcatcat tgcttgcaaa agaatcaata gcaaaataca aagattacca
    42001 acttcctgcc attatagtta ttccaggtat tggaggaagt atgggattag gtatgaatga
    42061 agtaagagaa tctagtaaac gtgctatagg tgcagatata ttatttaaag aatagatgaa
    42121 agttgaataa aagacaatct caaattttat tggtgctaaa tatatgtgct aataaaatat
    42181 aggagggaat atttaaattt tgataaagta tatgattgca ggtgagagaa tatgaaaaca
    42241 ggcacaattg taaaggtgtc aggaccgctt gttgtagcgg agggcatgag agatgcgaat
    42301 atgtttgacg tcgtaagagt ttcagataaa catcttatag gcgagattat agaaatgcat
    42361 ggagataaag cttctataca ggtttatgag gaaacttccg gtctaggacc aggggaagaa
    42421 gtagtttctc ttggaatgcc tatgagtgtt gaacttggac caggtcttat ttcaactatt
    42481 tatgatggta ttcaacgtcc acttgaaaaa atgtatgata tttcaggtac taatataact
    42541 aaaggtgttg aagtatcttc acttgataga acaactaagt gggaatttaa acctaaaaaa
    42601 tctgttggtg ataaggttgt agcaggagat ataattggtg gcgttcaaga aacagcagta
    42661 gtagaatgta aaattatggt tccttatgga gttaagggta ctataaaaga aatatattct
    42721 ggtgaattta ctgttgaaga tacagtttgt gttattacag atgaaaaagg taatgatata
    42781 cctgtaacta tgatgcaaaa atggccagtt agaaaagaaa gaccatatag agaaaagaaa
    42841 acaccagatt cacttcttgt tacaggtcaa agagttatag atacattttt cccaatcaca
    42901 aaaggtgggg tagcagctat accgggacct tttggaagtg gaaaaactgt tacacagcat
    42961 cagcttgcta aatgggcaga tgcagatata gttgtatata taggctgtgg cgagcgtgga
    43021 aatgaaatga cagatgttct tcttgaattt cctgaattaa aagacccaag aacaggcgag
    43081 tcacttatgc aaagaactgt gcttatagca aatacatcag atatgccggt tgctgcacgt
    43141 gaagcttcta tatacactgg tattacaata gctgaatatt ttagagatat gggatatagt
    43201 gttgcactta tggcagactc tacatcaaga tgggctgagg ctcttagaga gatgagtggt
    43261 cgtttagagg agatgcctgg tgaagaaggt tatcctgcat acttaggttc acgtcttgct
    43321 caattctatg agagagcagg aaaggtaaat tgtctaggta tggatgaaag agaaggaaca
    43381 cttacagcaa ttggtgcagt ttctcctcct ggtggtgata catcagaacc tgtcagccaa
    43441 gcaactcttc gtatagtaaa agtattctgg ggtcttgatg catctttagc atataaacgt
    43501 catttcccag caattaactg gttgactagt tattcactct atcaggaaaa agttgatgta
    43561 tgggcagata aaaatgtaaa tgataatttc tcagctcaaa gagctcaagc tatgaaactt
    43621 ttacaagttg aatctgaact tcaagaaata gttcaattgg ttggggttga ttcactttca
    43681 gatggagata gattgatact agaggttact cgttctataa gagaagactt ccttcatcaa
    43741 aactctttcc atgaagttga tacttataca tcacttcata aacaatatag aatgatggga
    43801 cttatattaa aattctataa gtcagcacaa gatgctatca agcaaaatgt tactataaac
    43861 gatattatca agctttcagt tcttgaaaag attggtcgtg ctaagtatgt agaagaaggc
    43921 gatatagatg cagcttacga ttcaattgaa gatgaaatag acaacgagct tgcagacctt
    43981 attaaaaaga ggggggctga agaactatga taaaggaata taagtcaata caagaggtag
    44041 ccggtcctct tatgttaata aacggcgtag aaggtgtaaa atttgatgaa cttggagaaa
    44101 ttgaactttc aaatggagaa attcgccgtt gcaaagttct agaggtaaat ggagatactg
    44161 cacttgttca gcttttcgaa agctcaacag gtataaacct tgctgaaagt aaagttcgtt
    44221 ttttaggaaa gagtcttgac tttggagttt caccagatat attaggtcgt gtttttagtg
    44281 gaatgggtag acctattgat ggaggtccag aaattatacc agataaaaga cttgatataa
    44341 atggagctcc aataaatcca gcagcacgtg attatccggc cgagtttata caaactggag
    44401 tctctgctat agatggactt aatacattgg ttagagggca aaaacttcct atattctcag
    44461 ggtctggttt gccacatgcc aatcttgcag ttcagattgc aagacaggca aaagtacgtg
    44521 gaactgattc taagttcgcc gttgtatttg ctgcagttgg tataactttt gaagatgctg
    44581 aattttttat aagcgatttt aaagcaactg gtgcaatcga ccgttctgta gtgtttgtaa
    44641 accttgcaaa tgacccagct gtagagcgtg tatctacacc tagaatggca cttacagcag
    44701 cagaatacct tgctttcgag caagatatgc atgtacttgt tataataacg gatattacaa
    44761 actatgcaga ggcgttgcgt gaagtttcag cagctaaaaa agaagttcca ggacgtcgtg
    44821 gatatccagg atatctttat actgaccttg ctactatgta tgaaagagca ggaaaaatga
    44881 aagggcatga agggtctata actatgattc caatacttac aatgcctgag gatgataaga
    44941 cacatccaat tcctgacctt acaggataca ttacagaagg gcaaattata cttagccgtg
    45001 aactttataa aaaagatata cagcctccta tagatgtttt accatcactt tctcgtctaa
    45061 aagataaagg tattggtaaa ggtaagactc gtgaagacca tgcagataca atgaaccagc
    45121 tttttgcagc ttattcaaga ggtaaggatg caaaagaact tatggctata cttggtgaat
    45181 ctgcactttc tgagattgat ttaatgtatg ctaagtttgc agatgaattt gagaaagaat
    45241 atgtttcaca aggatttaga actgatagaa ctattgagca gacattagaa atcggatgga
    45301 agcttcttag tatgttacca aaaagtgaac ttaaacgtat ccgtgatgaa tattttgaaa
    45361 aatatatgcc taaggagtga tatctgtggc tagattaaat ataaatccaa cacgtatgga
    45421 aatgactaga cttaagaaac tccttaaaac tgctacaaga ggtcataagc ttcttaaaga
    45481 taaacttgat gaacttatga aacaatttct tgagattgta agagaaaata agcgattgcg
    45541 tgaagaagca gaaaatgctc ttgatactgc ttataaaaac tttataatcg caagagcagt
    45601 tatgagtcag gagtatctgg gttcagcact tatgatgcca aagcaatcag tttcagtaga
    45661 tgtttctacg agaaatataa tgagtgttga tgttcctgtg tttgacttta aaactgaaaa
    45721 caatcaaagt gatatttatc cttatggtct tgcttttaca tcaggtgaat tagattctgc
    45781 tatggaagct ttctcagatg ctatgcaacc acttttaaga cttgcagaaa gtgaaaaaag
    45841 tgcacagctt cttgcacaag agatagaaaa gacacgtaga cgtgttaatg ctcttgaaaa
    45901 tgtaatgata ccaaattaca ttgagactat taagtatata gctatgaagc ttgaagaaaa
    45961 tgagagagca agtactacta gacttatgaa ggttaaggat atggtgctta aaaaagcact
    46021 tgaagaaaag aaaaaaaatg atttggttgt ataattaaat acttataaaa ataagtctaa
    46081 cattctactt tatagaggtt agacttattt tttatgttta aattaaaatg tagatactat
    46141 aaaaattaat atattgttta aaaacagact gtatttaact aaaaataata tatttaacaa
    46201 aaatttctaa aaattaacga actgttaatt tacacttaac tttatattaa caaattaggt
    46261 gtattatata aacataagca aaaacaataa aaaacaaata aaaaaaggaa aaaacacaaa
    46321 gggggaagat atgaaagaat ttatatttac ttgtctgtgc attgtagtga ttacatttat
    46381 gacaagttgc atatcaacaa caccacaaac tactcaagga aaaggaaata ataaacttac
    46441 aatatatgca gcactagagg aagagcagat agcttattat atggaaggtt ttagagaaga
    46501 gtatcccaat atagatgtag agatagttat ggattctcat ggtgtaatag cttcaaaact
    46561 attagcagaa aaagataatc cacaagcaga tattatatgg ggattatcag caatgaacat
    46621 gatagagcta aaaaaagatg gtgcacttga agcatataag cctaaaaatt atgataaagt
    46681 tgataaaaaa tttaaagata ctgaagatga tgtatcttgg gtaggaatga gtgtcccaga
    46741 gacagcaata gtagttaatt ataaggaact taagaaacta ggtatagata ttccaaaaag
    46801 ttatgaagat ttaataaaac cagaatataa aggacttata acaatgccaa atccagcatc
    46861 atctggaacg gggtatctta cagtatcagg gcttattcaa atgatgggtg aaaaagatgc
    46921 ttacaattac atggataaat tacataaaaa tatagccaca tatacacact cgggttcaaa
    46981 acctgcgaag ttagctggct ctggagagta tccaataggt attacacttg gatatagagc
    47041 tacacaacaa ttatctagtg gagaacctat agaggttgta tttccaaagg aaggttcagg
    47101 ctgggactta gaagcaaatg ccttagttaa aaaagataat ataaaaaaag aagcaaagct
    47161 atttttagat tgggcaataa gtgattcagc tatggataga tatgcacatg aagtagcagt
    47221 tacttccata aagacagata atccagttcc aaaaggttat tctaaacaac catttgaaca
    47281 gcttataaaa gaagttgatt taaactctgc tgccaaaaac agaagtacag tacttaaaac
    47341 ttgggaatca aaatacggtt caaaatctga aagtaagtaa agtttaaatt aataatttag
    47401 atgaaagaat tttagaagaa aaagtaggat ataaaattta aaataaaaaa ataactatat
    47461 aaggagagat aagatatgag ttacttaaaa ataaataatg tgtttaaaag ttatgaccaa
    47521 aaaagggttt taaataatat tagtttggat attgaagaag gagaatttct atgtttactc
    47581 ggacctagtg gatgtggtaa aactacatta cttagaataa tagcaggtct tgaagatgta
    47641 aatagcggaa ctataattct ccaggataaa gatattacaa atttagagcc atcaaagaga
    47701 ggttttggta tagtatttca atcatatgca ttatttccga atatgactgc ttataacaat
    47761 atagcttttc cactaaaaga gagaaaagtt tcaaaaggaa aaatagataa taaagttaag
    47821 gaagtacttg aaacagttgg attgactaat gaagctcata aatatcctaa agcattatca
    47881 ggtgggcaac aacagaggat tgcaatagca agagcattag ctcttgaacc aaagttttta
    47941 cttttagatg aaccaatgtc cgcattagat gcaaaggtta gacacaagct tagaatggac
    48001 attaaaagat tacaaaaaga acttaatata acgacaataa tggtaacaca tgaccaagaa
    48061 gaagctataa ctatggcaga taaaatagct attctaaatg gaggagatat aatgcaaata
    48121 gggactccag aagaaatata ccaaaatcct caaaacctat ttacagctca atttatagga
    48181 gatacaaact gttttgataa tggagattct atattaactg taagaccaga atatgttcaa
    48241 atagagaaat cgacaaaaga aaactaccaa ggaataatat caaatataga gtttagaggg
    48301 aatttattga gagttgaaat aaaagataaa ttaaatgaaa atttcataat aagtgatgct
    48361 tctataaaag agtgggttaa tttaaattta gtagaaggtg accttgtaaa aataagtata
    48421 gacgaaaaat actatttaaa gtatccaaaa gttaaaggag cataagtgta tgaataataa
    48481 tgctataagt tctaaaagta taagtcttaa atcaaaaatg aatttagata taaaaaaatg
    48541 tatgcttaca gtattagtta tgtctttagt aatattttta ttagcaccta taatatatct
    48601 atttgtacag gcttttttag ataaagatgg agtctttgta ggattacaaa actttcaaga
    48661 atacttggct tctgaatctc tattaaattc tctaaaaaat acagtatttg tatcagttat
    48721 atcaactgta atatcactaa cacttgcatt agtatatgca tatgcattaa ctagaacaaa
    48781 gattaaattt aaaggttttt ttaaatcatt agctatgttt cctatgtttg ctccaacaat
    48841 gatgcatgca ataggtctag tatatttatt tggaaatcaa ggtttggtaa ctaatttact
    48901 tggagtgcat gttccaatat atggagcagt gggaataata ttggcacaaa ttatatatgt
    48961 atttcctcaa tcatttcaaa tactttatat atctctaagt tcaaccgatt atagactata
    49021 tgaagctagt aatactatgg ggataagcaa gataagagaa tttataagca taacaatacc
    49081 aagtataaaa tactctttaa taagttctgc attcgtatcg tttacattat gttttacaga
    49141 ttttggagct ccaaaggtga taggaggaga gtttaatgta ttatcaatag atgtatataa
    49201 gcaaattata gggcaacaga atatgccaat gggagcaact gtatcaatat tacttttaat
    49261 acctgcaata atatcgttta tagtaactaa aaaaattgaa aaaaatcaaa attcatatat
    49321 aacttcaaag tcaattccat ataaggttaa aactaataag ttaagagata gtattttagg
    49381 aggggttgta ggaattattg catttggtat aatagctgta atgttaactg taatcttatc
    49441 ttcattaata tcagtttggc catatgattt aagactgaca ctggaacatt tttctatgaa
    49501 aaacagtatt gatgggatta aaccatttat aaattcaata aaaatgtcac tattgacagc
    49561 tattctaggg acgagctttg ttttcttatt tgcatatttg aatgaaaaaa cagaaaaagc
    49621 tccatattta aaatcatttg ggtatttttt aagtacattg cctatggcat tgccaggatt
    49681 agttttaggt atagcttatg tattattttt taataaatta gagtttaatt ttatggatac
    49741 aatatacatt aagaatttgt ttaatggatt atatggaaca ttacttataa tggttatatg
    49801 taatatagtt catttctttt cagtagcatt tataacagct actactgcta ttaagaaagt
    49861 agataaagaa ttggatatgg tagctaaatc aatgggaata aacagcgcat caattcttaa
    49921 gaacgtaact ataccacttt gtttgccagc agttttagag aactttatgt actttttcct
    49981 aaactccatg gtgacaatat cagcattagt ttttatatat actgcaagtt caaaagtagc
    50041 tgcaatatca attgtacaac tagatgataa ggggagtact gcacaggcag catcactagc
    50101 tgtgttaata ttagtcacaa atatattagt gaaagtaata tatgaattta taaagaatcg
    50161 tttagaaaaa agaacaaact ttaattaaat aatttatctt ataaaaacac aaatttaaaa
    50221 aagtctattc ttgtgattta ttatttaaag aatagacttt ttaaatttat tattgatatt
    50281 gtttattaat tttccttttg ttatcataca tttgagaatc tgcacgacga tatgtatcaa
    50341 ataaagaaac atctactttt tcatcaaaaa tagcatatcc aatagacatt gataatttta
    50401 attcattagt tgagttttct tcaactattt ttaaattaat attatttata atattattta
    50461 tttctttgtg agataaattt tttagaataa ttatgtattc atcacctcca atacgataaa
    50521 ctatatattt tttatttatt acatattgta taattttact tgcttgctta atatataagt
    50581 ctcctgtctg atggccaaat ttatcattaa tcttttttaa accgtctaaa tctattgata
    50641 tgatagatat tagattcttt agatttgaat tgtttaagtt attcatatct atttcaaaag
    50701 catttctatt ttttaggcct gttaaataat ctgtattagc aaaatcagta tatgtaggat
    50761 tagatattct tttaaataga atcactgcaa tcaatgctga tattagacaa gttaataatg
    50821 ctattattgg tgtaactata cttataaatt taaatgtatt gtattgatgt tttgcttcaa
    50881 attcaattcc tattactcca acaaccttac caacatcatt gtgaatagga aaatacgata
    50941 taaatatgta tccccaagat gttgatttaa tctttttagg taacaatata tgattatcta
    51001 atgctttgtt aaggtctccc caaatctctt tttctatcaa atcaccagca tttctaaaat
    51061 cactcctaga tgaatttaaa ccatcaacaa catatactag tgatccatct tttgtttttt
    51121 tagcagtata tagatacatg actccagtag tattttttac agattctaaa aggattttag
    51181 aacttttata agactttttt gattggtctt ctttagaatt aatttcagta aaggtatttt
    51241 tatcaatatt tctttctaca tattcataga tatgttttga cctctcactt aaagagtata
    51301 tcatgctctt ataagttagt gtataattaa aaaaatatac acatgaggaa gatattatta
    51361 caataattgc agtaagtatt gaaacctgca tatcaactct attgaatttt ttatttattt
    51421 tcatagctta aatgtcttgt gaaaagaacc tcccacaatc tccccataat taatatatat
    51481 ctataaattt caccataata tattcatata ttatcaaatt tgtgtggaaa ttacaattag
    51541 taaacatgct taaagcattc aaat
//
LOCUS       DAEQCW010000014        51561 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.014, whole genome shotgun sequence.
ACCESSION   DAEQCW010000014 DAEQCW010000000
VERSION     DAEQCW010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 51561)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 51561)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..51561
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.014"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            568..1974
                     /locus_tag="KRO40_000888"
     CDS             568..1974
                     /locus_tag="KRO40_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBH2091720.1"
                     /translation="MNTGFPKDFLWGASSSAFQVEGAWDKDNKGKTVADYNSFKKSHL
                     QADTKVASDFYHNYEEDIELMKELGMKTYRFSISWARIIPDGEGEINQKGLDFYNKII
                     DKLIECDIEPFVTLYHFDLPFKLVEKYNGWESRETVYAFERFAKICFKHFGDRVKYWQ
                     PHNEQNLIVRVEERINIYDETDSWKIDKMRAQMDYNLCLAHALAVNACHEMIKESKIG
                     AAVSSSVTYPLTSKPEDVYAARMNDNFKVYYMLDMHHYGEYPGYYMKYLEKRNIVPHM
                     EDGDKEILKKAKMDFIAVNYYRTNCAEALPEDSQHPFGLREGTVDFSMYGLFKMSMNP
                     NLEASEYGAAIDPSGLRVALNEYWQRYHLPVIITENGLGAKDILEDGKIHDDYRIDYL
                     RSHINACKLAIEDGVEMIGYCPWSFTDLLSSSQGFNKRYGLVYINRTDHEVLDLKRIK
                     KDSFYWYKEVIENNGIVK"
     gene            2002..2850
                     /locus_tag="KRO40_000889"
     CDS             2002..2850
                     /locus_tag="KRO40_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2091721.1"
                     /translation="MYITKVLNNSLLLAKDDNDEEIILMGKGIGHNYKAGSELNKKDI
                     EKIFVLHDENIKKSIIQLATEIDAEYFGIAQMIIAYGIEKYNLKLMNHIYLALTDHIA
                     FAVRRFKEGIMIENHYLFEIKEFNPKEYDIGKYAITVFKEVLGLDLPEEEIGNIAGHF
                     INAQQDNPYSDRNKRSAKIVNAILQIVHYHFSIVYNKESFYYRRFVMHLKAFSQRFLA
                     NEPSREKIDFIYEQVQKNCKEEYECVKKVGAYMYKEYSRELPRQEELYLMIHIHKILG
                     ELCENS"
     gene            3511..4203
                     /locus_tag="KRO40_000890"
     CDS             3511..4203
                     /locus_tag="KRO40_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003020373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091722.1"
                     /translation="MNKVLIIDDDKDLCILLKKSISIEQIEANYCHSGRDGLAELSKQ
                     DYQLVVLDVMMPGMDGFETMEQIRKYSSIPILMLTSKSDNYSKVHGLRAGADDYLTKP
                     FEITEFTARVLSLIRRYTRFNPKNEEPQQLSFKGLLIDLDQHTVTTNGEPMLLPPKEF
                     GVLLYCAKHQGKILTKQQIYEAVWGEPYVYDDSNIMAIISRLRKKIELDPSSPIYLQT
                     IKGIGYQFNTEV"
     gene            4200..5135
                     /locus_tag="KRO40_000891"
     CDS             4200..5135
                     /locus_tag="KRO40_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091723.1"
                     /translation="MKMDEQTIILFLLLLSIGLLFLSIFAFSKLGHIYKRLKDIEEIL
                     ADVQIGDENRKILIKPCDVMAPLVYQLNEIVYDYENKLLSLKKSDKASKQLMTSLSHD
                     VRTPLTTLIGYLDAVHSGIVIEQEREEYLEIARRRAYDLKDYIDVLFDWFRLNSDEFT
                     LSIESVEIAELSRNILKDWIPIFHEKKLNFEIDIPENRLMVNLDPDGYSRVVNNLVQN
                     VLAHSKARQIKITMSEDSRMVLLRVEDDGVGIARENLPHIFERLYKCDKGRSEKGSGL
                     GLSIVSQMVERMGGQISVESEIGKYTIFTVSLPLI"
     gene            5283..6206
                     /locus_tag="KRO40_000892"
     CDS             5283..6206
                     /locus_tag="KRO40_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013273760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091724.1"
                     /translation="MNNLIIETKNLTKQYGAQKSVSNLNIHVQKGRIYGLLGRNGAGK
                     TTTMKMLLGLTKPTTGEIKIFGQDIHNNEKKLLPRIGCLIESPGFYPNLTGTENLKIF
                     ARLRGIPKKNAVESALDVVGLPNNDKKLFSQYSLGMKQRLAIALAIMHDPQLLILDEP
                     INGLDPIGIAEVRTFIRDLCTERGKTILISSHILSEIALLADDIGIIDHGILLEEESL
                     AQLEEKNSKYIHFAVSDAAQAARLLETQLNLKNFKVADNYNIMLYDTDVSVAEINRAF
                     ILNNIEVSESHLCEDTLEDYFKKVTGGEGIA"
     gene            6190..6960
                     /locus_tag="KRO40_000893"
     CDS             6190..6960
                     /locus_tag="KRO40_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091725.1"
                     /translation="MKELLDIISCEFSKLKRLKFILISILGACLFPIPATILIAKDNL
                     PFEQLFKLVVNFGYFLLLPIVLSIVASQLFFIERDNDVLKNLATVPVQKGKLALAKLA
                     VLLFISLFYSVAGLGATIIGGFIVGIVEGVAVKLGMSIAFGIMFFVTVLPVVVLIVYF
                     NRSYIFSIILSFVYAIFNFSISLNIINFEPNNPILSVLPAPVIMRWWMAFWGDPTGEY
                     TALRQPYLLSTPACVGILCLITIIAVLLICMIYKKQEN"
     gene            6970..7752
                     /locus_tag="KRO40_000894"
     CDS             6970..7752
                     /locus_tag="KRO40_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091726.1"
                     /translation="MLDIITTEFQKIKRYNILWIGVVAVLFSALLAVFQVVSSHGSDP
                     LTYESFANGVIWNNFSLSFPFGITLIGGYLINREYTDQTLKNILTVPISLRKLLVGKL
                     IAVGGITVLLSLFSFLCTFILGLLFCNINISVTLVVKSLVQILSVNLYCYVAVLPIIA
                     YFGRKQNAFLTGVGIAFVYGFCGVFVAGRNLTDFYPITAGLGLVGYNNGAGTVYQPLI
                     GAMTLIVILILTTILLVFTPNYDKVMTISKKKGIKHKKYSHK"
     gene            8128..8664
                     /locus_tag="KRO40_000895"
     CDS             8128..8664
                     /locus_tag="KRO40_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBH2091727.1"
                     /translation="MNLKGTKTEKNLMAGFAGESEARNKYTYYASKARKEGYNQIAAI
                     FEETANNEKEHAKLWFKLLHDGMPSTEENLKDAAAGENYEWTDMYAKFAKEAREEGFD
                     KIAYLFEAVGKIEKEHEERYLKLLENLNEGKIFKRDEEVVWQCQNCGHVYVGTEAPEK
                     CPVCDHPKAYFNIKAENY"
     gene            8696..9085
                     /locus_tag="KRO40_000896"
     CDS             8696..9085
                     /locus_tag="KRO40_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBH2091728.1"
                     /translation="MKFSKQRELILNEILNNPVHPTADYLYENLKKDNPNLSLGTVYR
                     NLAQLTEHGFIRKVSIPGYPDRFDGRIDNHYHIICEVCGEVYDLESEVLNNLQELISE
                     ETDIKITSYNISFKGICNNCKRCSQVG"
     gene            9122..9508
                     /locus_tag="KRO40_000897"
     CDS             9122..9508
                     /locus_tag="KRO40_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="desulfoferrodoxin"
                     /protein_id="HBH2091729.1"
                     /translation="MCSEQKFFICETCGNLVGMIQSGGVPIFCCGKPMKELVPNTTDA
                     AVEKHVPVIEVDGNNVTVKVSSTTHPMTKEHHIAWVYLMTEQGGQRKCLAVDGEPVVK
                     FALNDDDKVISAYAYCNLHGLWKAEL"
     gene            9635..11077
                     /locus_tag="KRO40_000898"
     CDS             9635..11077
                     /locus_tag="KRO40_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH2091730.1"
                     /translation="MSIYKCSVCGYIYDESKNDKTWDELSEDWECPVCTKGRSYFGKI
                     STVYYEEDEKIAEDIVEDESKLNTEKEGDLNYLSTYLRRDDEVEKHMDIIHEMAVTGK
                     SIIEPMRTKLPVISWDDILIMGAQLNPLPLNEHDEVNTTTIIGKKAKKPMIIENPVYI
                     SHMSFGALSKELKIALAKGAAQNKTAMCSGEGGILPEEKEASYKYIFEYVPNKYSVTE
                     ENLKNSDAIEIKIGQGTKPGMGGHLPGEKVTEEIAKVRNKPVGQDVISPSCFEEIQSK
                     EDLKKLVDELREVSEGRPIGVKISAGHIEKDMEFIAYAKPDFVTIDGRGGATGASPKL
                     LKDATSIPTIFALYRARKYIDTHGLDIDLVITGGLRISTDFAKAIAMGADAVAIASSA
                     LMAAACQQYRICGSGKCPVGVATQDEELRKRLHIENSANRVANFLNVSLEELKTFART
                     SGHKDIHDLSVDDLYTVNSEISNYTNIQHV"
     gene            11374..12189
                     /locus_tag="KRO40_000899"
     CDS             11374..12189
                     /locus_tag="KRO40_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2091731.1"
                     /translation="MERLKIQVLVDNNTYIDRYFVGEPAVSYYIEIDGNRILFDSGYS
                     DVFISNAEKLNIDLGNLTHVVFSHGHNDHTRGIQFLENRYDLSTIELISHPNCFIPRK
                     HGEKSIGAPFSAEEIKNIFMYNPKDKPFNLSKNCVFLGEIPSINDFEKRAKIGKCKIG
                     DLWEDDYVLDDSAIVCKTDKGIFIITGCSHSGICNIVEYAKKVCRDDRVIGILGGFHL
                     FELNNRLDSTIQYLDKEEIRMLYPCHCVSFKVKAKMNEILNINEVGVGLTISI"
     gene            12791..13975
                     /locus_tag="KRO40_000900"
     CDS             12791..13975
                     /locus_tag="KRO40_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091732.1"
                     /translation="MQKSVKKAKVTGSMLAIFGVASVLFSSHAGGGFATGNQETQYYV
                     QYGWTAPLMAILAMIILTATMREVIIMYNNNNCRNYKDLFCELWRPYPKLEIIWEIYY
                     YLMVLIAVSAVIAGAAAVFQSIGVNYFVAVFIIGVVLLVFTIFGAMLVSKAATAMTIA
                     ILVCTLTIFIVGIKAKVPEITEILSNRTSFTPGYIKPILNTFIYAGFQSVVIPTLAGC
                     SRPLLKNSKEATKAMIISFVMNAIALGLAVTMLMGWYREIIAAGQTTLPTLYVAGQSG
                     NHTIYIIYNVALFLCLMSTGVTTIFGLVNRFEDHKALSFLSSRMKRRVFTACAIMVVS
                     MLISLTGLSNIVKYGYGYCGYLGLFTIVIPFLTLGHYKNKKFAKENPEAKWPAELNEN
                     VN"
     gene            complement(14352..15461)
                     /locus_tag="KRO40_000901"
     CDS             complement(14352..15461)
                     /locus_tag="KRO40_000901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH2091733.1"
                     /translation="MDFKSLGISENTINILKKLGITTPTPIQKESIKLIKEGKDVIAE
                     AQTGTGKTLAFLLPIFENISLDINDIQVLILSPTRELAIQITEEAMKLKESKDVSILA
                     AYGGKDIGSQIKKLKGNIHMIIATPGRLLDHLNRKTIDLSKLKTFVLDEADQMLLMGF
                     KNEVEAILKETSNKKQTLCFSATINSQVKKLAYRYTKNPVVVSIQKEEITLNNIKQEV
                     VETTDRKKLDALCKVLDEDNPFMAIIFCRTKRRVDHLEEALAIRGYNCQKLHSDIAQS
                     KRERIMKSFRSLDIQYLIATDVASRGLDISGVSHIYNYDLPETPEDYIHRIGRTGRAG
                     EEGYTCAFIDPKNERMLSEIETAIESKISRRIIEL"
     gene            15924..17117
                     /gene="nifV"
                     /locus_tag="KRO40_000902"
     CDS             15924..17117
                     /gene="nifV"
                     /locus_tag="KRO40_000902"
                     /EC_number="2.3.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocitrate synthase"
                     /protein_id="HBH2091734.1"
                     /translation="MCVISKDRAKEIKIVDTTLRDGEQTAGVVFANREKIMIAEMLSD
                     LGVDQIEVGIPTMGGDEKNVIKHICSRNLKSDIMAWNRAVIKDVEESISCGVDAVAIS
                     ISVSDIHIENKLRTSRGWVLENMAKTVEFAKKNGLYVSVNGEDASRADIDFLTEFINV
                     GKQAGADRFRYCDTVGVMNPFSIKNAIETLYERTNFDIEMHTHNDFGMATANALAGIA
                     AGANYVGVTVNGLGERAGNAALEEVLMALKCVYKCDLNNIDTRKFRGICEYVAQASGR
                     ILPTWKPVVGDNMFIHESGIHADGALKDPHNYEPFDPSEVNLERKIVIGKHSGRAAVV
                     NKLSEYEMYISPENATKLLNAIRATSIRLKRSLMDKEILQLYCDILAHEKGTTEEEAV
                     RGSYI"
     gene            17142..19067
                     /locus_tag="KRO40_000903"
     CDS             17142..19067
                     /locus_tag="KRO40_000903"
                     /EC_number="4.2.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aconitate hydratase"
                     /protein_id="HBH2091735.1"
                     /translation="MGDNIVYKIIKKHIVDGEAVAGSSIGIKIDQTLTQDSTGTMTYL
                     QLEAMGIDKVKTKRSVAFVDHNMLQQGFENADDHKYIQTVADKYGVYFSKPGNGICHQ
                     VFLERFSTPGDTLLGSDSHTPTAGGVGMMAIGAGGLDVALAMAGGAYYIKAPKVCKVN
                     LVGKLNNMVSSKDIILEVLRKQTVKGGVGKVYEYGGEGVKSLSVPQRATITNMGAELG
                     ATTSIFPSDEKTLEFFKSQGREDAWVELKPDADAVYDEEITINLDELKPLAAKPHSPD
                     NVDEVENIGKIKIDQVAIGSCTNSSYEDLMKVAQILKGNKVHKDVSLVIAPGSRQVME
                     MIARNGALADIISAGARILENSCGPCIGMGQSPGTDSVSLRTFNRNFYGRSGTLSAQV
                     YLVSPEVAAVSAIKGVLTDPREFDIKFTNLDVNEFLIDDSMIIKPADVGSDVEVVRGP
                     NIKPFPLNTELSQSIGGKVILKTEDNITTDHIMPSNAKLLPFRSNIPYLANYCFNTVD
                     TEFPQRAKDNNGGFIVGGDNYGQGSSREHAALAPLYLGVKGVIVKSFARIHKANLINS
                     GIIPMEFCDEKDYENISLLDNLEIPNILDNLGSGILEVKNTTKGTSFKVKVELSAKEV
                     DVLKAGGKLNYTKNQAN"
     gene            19089..20084
                     /locus_tag="KRO40_000904"
     CDS             19089..20084
                     /locus_tag="KRO40_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocitrate/isopropylmalate dehydrogenase family
                     protein"
                     /protein_id="HBH2091736.1"
                     /translation="MYKVTLIPGDGIGPEVAKAMKKVVEATGVEIEWEEVNAGEAVIE
                     EYGTPLPEYIIDSIKKNKIAIKGPITTPVGKGFRSVNVTLRQALDLYVNLRPIKSFKG
                     IKSRYEDVDLVVVRENTEDLYAGIEHKIGDYAAESIKIITRSASERIVDFACNYVKDN
                     KRKKVTAIHKANIMKMSDGLFLDVFREVASKHGVEYDDLIVDAAAMNLVLNPENYDVM
                     VMPNLYGDILSDLGAGLVGGLGIIPSANIGKDCAIFEAVHGSAPQIAGQNKANPTALI
                     QSSVMMLRYLGEYENAQKIETALEKVFLEGSKLTVDLGGSASTTEFADEVCKYIV"
     gene            20410..20883
                     /locus_tag="KRO40_000905"
     CDS             20410..20883
                     /locus_tag="KRO40_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2091737.1"
                     /translation="MVVSVEVCLIKTLDSNILREVGTLSRAVNSINDIKYKELKLQKG
                     QFTFLTRICENPGINLVELSNMLKVDKATTTKAIQKLIKAGYVDKKQDEFDKRGYNLT
                     PTDKSLEVYELIIEEENRSIEICFDNFTDEEKQVVTKLLEKMSKNVENEWFKVKR"
     gene            20917..21411
                     /locus_tag="KRO40_000906"
     CDS             20917..21411
                     /locus_tag="KRO40_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091738.1"
                     /translation="MIRKANMNDLESIMKIIKSTVEEMKTYNNTQWDENYPLEKDFVS
                     DIKKQDLYIYEVDGEVAGFICLNYEEPEEYLGLNWSSNKKAMVIHRMAVNPNFRKTGI
                     ASKLVDFAEKLAVENNVSYLKSDTYSINSKMNLLLTKCGFIKIGEMSFLGKEKSFYCY
                     DKIL"
     gene            21508..22029
                     /locus_tag="KRO40_000907"
     CDS             21508..22029
                     /locus_tag="KRO40_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase"
                     /protein_id="HBH2091739.1"
                     /translation="MIGFLKKRRSIRKYKDVEVEKEKLDKILKAALLAPSSKGLRTWE
                     FIVVDDKEKLINLSQCRTKGGGFFLKNAPLAIVIIADKEKNDVWIEDASIAASYIQLQ
                     AHELGLGSCWIQVRNRMHDDNIEADKYIREELKVPSKYSVECIISIGYPDEEKKAYSD
                     SDLDYKKVHFNNF"
     gene            22218..22529
                     /locus_tag="KRO40_000908"
     CDS             22218..22529
                     /locus_tag="KRO40_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH2091740.1"
                     /translation="MGIFKTKMDEDWKVNYIKEFNEMRDSYESKLQKKQFEVDSLKSE
                     LDRLRSYKNSLKPKEKQITDDDINNIKSLRRDGLSYKEISNQTSWSKATVSRVLNGLY
                     D"
     gene            22557..23243
                     /locus_tag="KRO40_000909"
     CDS             22557..23243
                     /locus_tag="KRO40_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2091741.1"
                     /translation="MKYSYKKCIIDSILLMFIVQILRMILNYVLLSQFEFTLENFNII
                     NLISFTLVGLSLILFLKDNSLYNKVRNRKITEAFEENKNNILIEKCKLILFVVVLSLA
                     IIVTYCTKGYVLFNVTMMTLSVLIVPIFEELFFREYIWNYLSNFIKSKSKIICITSIL
                     SGIYNIGYIDVIRNYVILYNNSSYTFEVIISKIMIGTVFGIVLGLVKYRFRDVGFCIL
                     LRSLFAIFIR"
     gene            23475..24359
                     /locus_tag="KRO40_000910"
     CDS             23475..24359
                     /locus_tag="KRO40_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBH2091742.1"
                     /translation="MKFVTFCSSNEEKIGVFNSETNSIYEINSLGLSKLYTDMNNFIE
                     NVSTGDLEKIKNNSFENAKCYKLEEVKLCSPIVRPKKDIICLGLNYKDHVNEIPDGVI
                     KNVVMPDYPIYFSKRADKIIGVDDKISLHGDLVEKLDYESELAVIIGKEGINISKEDA
                     YEYIFGYTIVNDISERALQDKHVQWFRGKSLDTHTSMGPYIVHKEEFEHPLKLDISSV
                     VNGEVRQNSNTEYFIFDIPTIINDLSRGMTLKPGDIISTGTPAGVAMGMNPQVYLKHG
                     DIVECKVEGIGVLKNIVD"
     gene            24458..25633
                     /locus_tag="KRO40_000911"
     CDS             24458..25633
                     /locus_tag="KRO40_000911"
                     /EC_number="2.1.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolecarboxamide
                     formyltransferase"
                     /protein_id="HBH2091743.1"
                     /translation="MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDA
                     FNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPLSDTLKQIYFVDDLELSPLACAY
                     AMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTDEALEILKGKRKGN
                     YNIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLI
                     IALITLKYTQSNSVCYAKDGQVIGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLK
                     FKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTGEGKRAWLKTLTGVA
                     LGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH"
     gene            25761..26615
                     /locus_tag="KRO40_000912"
     CDS             25761..26615
                     /locus_tag="KRO40_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091744.1"
                     /translation="MALNIRNYSLLCNQGTAKFNEDVVGINPFGAWVLDGATGLNGKN
                     LVSTESDARWYVQWWNRYLYKNINKEESLKSIINTGIIEVKKEYELRLNGFKVEKLDL
                     PSSSIVVVKFHENKVEYFLLGDCALFIKNGDSKVIKDRSICKFDNTVFDEMSKLSNLE
                     EMAFDEIRTSVMDTIVSNRLKKNTKEGYWILDFDEEAVENSIYGYIEIKKDFQLMLTS
                     DGFTSACDRYNLIKEEELIRIAEKFGIGYIHNKVRDFEDNDYKAVKVPRFKVKDDSSC
                     LYLDIYND"
     gene            26659..27894
                     /locus_tag="KRO40_000913"
     CDS             26659..27894
                     /locus_tag="KRO40_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HBH2091745.1"
                     /translation="MKILHIITQKPNSTGSGIYLSGMIKGFEKIGHKQAVIAGIDVND
                     DVNCFPSEVSFYPVKYNCGELNFPVVGMSDSMPYESTRYKDLNIDMINRLKYQFKVNI
                     DKAMNDFKPELIICHHLYLLTAFVREMVKDIKVMSICHGTCLRQLNTIDLEKEYIIAN
                     IRKLDLIFALHENQKYDIIKTFGVSESKVVVIGSGYNDDIFYNKNYKIKDDKIKIVFA
                     GKICKSKGLIPFIKAISKLKYSKDLIEVNFAGTGSDIESYNEIVKLASKSPFKMNFLG
                     KLEQRDLAELFNRSQIFVLPSFYEGLPVVVLEALSCGTDVITTDILGVKEWIGSEINN
                     SGKIEYISLPFMEKEGIPKDEELYDFENNLYNAIDSKIQSLLNNSNKKTSVDMSKKTW
                     DGLAYRINEVILMDELCLV"
     gene            27995..28936
                     /locus_tag="KRO40_000914"
     CDS             27995..28936
                     /locus_tag="KRO40_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp25"
                     /protein_id="HBH2091746.1"
                     /translation="MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAG
                     LISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAAILLTNKDDIPEATLQRLNRVTK
                     IYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
                     FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSD
                     YIVSRYRATRIGGVDRYQTNKNVIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVV
                     LVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK"
     gene            complement(28987..29346)
                     /locus_tag="KRO40_000915"
     CDS             complement(28987..29346)
                     /locus_tag="KRO40_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091747.1"
                     /translation="MDLFEVNIVLNSGTAGGMNPKLKIFNMVISTEVCHHDVTQDTLT
                     EFHSWLKTVFFEANCELIKISEMAVKKTNQEETVFWGRILAGEAFITNKGRKKINEKE
                     AYLHLIASSHIFYTIIK"
     gene            complement(29372..29836)
                     /locus_tag="KRO40_000916"
     CDS             complement(29372..29836)
                     /locus_tag="KRO40_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091748.1"
                     /translation="MNLGNSLFQARKKHGLSQEDVAEKLGVSRQTVSKWETDETVPDI
                     RQSKKLAILYNVSLDELIDFDIDMEEIQEAINKTSEETEEKINWTNAWGKKYPILLKY
                     QTDVNISNYAYKVNMMLDELKQEYQYNELEAMLILKDILYNVWKNRKSKRKQ"
     gene            complement(30004..30212)
                     /locus_tag="KRO40_000917"
                     /pseudo
     CDS             complement(30004..30212)
                     /locus_tag="KRO40_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004071281.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 family protein"
     gene            complement(30256..30609)
                     /locus_tag="KRO40_000918"
     CDS             complement(30256..30609)
                     /locus_tag="KRO40_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBH2091749.1"
                     /translation="MDRKRELKQLYKEMKFDTGVFIIKNDITKKIYLGKSNDIKSKFN
                     SLKFQLGAGSCMIKELNNEWKKYGEKAFTFEVLELIKHDDNKTEKDYLEELDILEMVW
                     LEKLKEDNTYEIYSI"
     gene            30905..31816
                     /locus_tag="KRO40_000919"
     CDS             30905..31816
                     /locus_tag="KRO40_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="HBH2091750.1"
                     /translation="MNKKIELIGNFASDWIRYSDYEYKITEEDELYIVPTEDAVFTMY
                     NPFDVADDIIVDIIRIGQEALQDISKETKEMKLKKEILEFVKKYGLLGLIYSSVYNRD
                     IVGEERVLMIEKNYITKENILSTDEYVNMFIPFASDEDVYFKKYRRGIDVSKREESPK
                     FFGKRPLILDLVFSKFYTEQLDWIVSFAKDMCKHFNQICVYKNTSNLLTESVTIMSGG
                     FNPQKIGFSISQLDKPIIAWEFDSLKTAIETIYAFAITSEPSSLNKCKYCGKIYIPTN
                     SKSQYCSPSCRNCSNVKKSRSRAKKDK"
     gene            32077..32511
                     /locus_tag="KRO40_000920"
     CDS             32077..32511
                     /locus_tag="KRO40_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091751.1"
                     /translation="MISPIILSSINQNLKEIERNELLETNIESGDYGLALSESDVKDI
                     INSRDNTLKGYGRIELDIKVTKQLIENIYTSQYTNVDNYLEAINDMQEIFYYLKNETD
                     DKICDDEIIEILGDFYEKFSGNMDNVRGEADEFAKKFKFGEV"
     gene            32534..34069
                     /locus_tag="KRO40_000921"
     CDS             32534..34069
                     /locus_tag="KRO40_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091752.1"
                     /translation="MLNNLSNININENNLIKNQYSISLLKECLNCKVIDEREVYNIQQ
                     EISLILMDLIKKYTNGQSTSVKTEVAEKLLISIWYAIDAYINKLGDIEKRVVELTAKN
                     VKKVYLGGIEILEEELVRLKDFYKLMMSRKLDTNSIAYNDTLMELSSFFKSYIVKFEA
                     QDVPVSIDYPLALDDMDVKGIYYVKNYIESIDIENRFCNLFKKKDREKLFYDYGVTYK
                     IDCDVILVNLFELIMNNCIFSTILGNEVTNLEISKYEYEFLEKQFKNMYNNITEDKVI
                     DSEESNIIELIEVDDSFNTEVDSNLDYNDFEEINREIRINKKITLLLMEAIEVLIKRL
                     SIEDEDVIRYIKKYEKIFIESVLSSIKSNTFKSMVTVSKNKNEHLEDYIVDDESKLDD
                     ESFREIFNEILDSTSIIEKIRIIKENINAKKDFIDILESECLFGEEYLMLFASLSELE
                     LAILGSVVFYEDIRMREINILEFMLNEKTETTLWKIEYIKFMKRQSEDKIYSIEEHMN
                     KIN"
     gene            34153..35520
                     /locus_tag="KRO40_000922"
     CDS             34153..35520
                     /locus_tag="KRO40_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2091753.1"
                     /translation="MKEYIINNVEEIREELIDLSKKIWENPELAFEEKYASSIQKEYL
                     KSKGFKIEEVENLPTGFIASFGEGKPVIGILGEYDALPELSQCVSAERKPLVEGKAGH
                     GCGHNLLGVAGVGAVVSIKKLIEENKFNGTIKYFGCPAEEEGGGKTVMCINGCFDDVD
                     CAFTWHPFDINAPWRGGSLANLSVKFKFKGITAHAAQAPHNGRSALDAVEIMNVGANY
                     LREHVIDSIRMHYVITNGGGRPNVVPGFAESWYFIRGKKAKDAEHVLDRLIKVAQGAA
                     MMTETEMEYKVTDGIYDYIPNQCLTDLVYDNMVFVGCPKNTPEEEEFAKKLCDTLTRE
                     ERLGVATSLQNDKSIVESYIHKEIVDGDKDKGLAGSTDVGDVSYVIPVAQFAMAAWPV
                     GIASHTWQSCSSAGSNIGFSAMINSAKVLACSAYDVFMDTKIIDEAKIEFDKSLDGQK
                     FKPLV"
     gene            35555..35779
                     /locus_tag="KRO40_000923"
     CDS             35555..35779
                     /locus_tag="KRO40_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifU family protein"
                     /protein_id="HBH2091754.1"
                     /translation="MREKVEKVLEEKIKPVLQRDGGDVELIDVNENGVVLVRLQGACS
                     GCPGATMTIKAIIENVLVSEVPGVTQVLGV"
     gene            complement(36130..36528)
                     /locus_tag="KRO40_000924"
     CDS             complement(36130..36528)
                     /locus_tag="KRO40_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03987 family protein"
                     /protein_id="HBH2091755.1"
                     /translation="MNYKLILAIVFITSALIFYTIGVFGERKAKILKKKHVIIFWLGF
                     IFDTLGTFTMSNIANSHTFEVKSALSQNLHSITGLLAIVLMLFHASWATFVLYKDDEE
                     KKKFFHKFSIVVWTIWLVPYFIGMFIGMAG"
     gene            complement(36531..36932)
                     /locus_tag="KRO40_000925"
     CDS             complement(36531..36932)
                     /locus_tag="KRO40_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2091756.1"
                     /translation="MLLKELYSKTMYTVEENFKENGLTHQQIIVIKLIAHNQELTISQ
                     LCDEMSLAKGTVSGIISRLEQIGYIEKFKKSNDKRNTYVKFTTTGFEFATNFKIKMQE
                     SFDDIFKNCDENELSDLVKNLRNILAKVKER"
     gene            37292..38278
                     /locus_tag="KRO40_000926"
     CDS             37292..38278
                     /locus_tag="KRO40_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091757.1"
                     /translation="MLKDILKKLLQFILVMFLLSFIVFYMARLAPGDPLISYYGDGVE
                     RMSTQEKENAMKKLGLDEPIYSQYIKWISNASKGEFGISFKYKQNVTSVINDVYINTI
                     ILGGSGYILTFVLALLLGIFCTLHEDKLIDRIICKLGTITNCIPSFWVALVLILIFSI
                     NLSILPSSGAYSMGEESSILSRISHLILPLTVLILSHLWYYTYMIRNKLLEEIREDYV
                     LLCKAKGLNNRTIVFKHCLRNIMPSYISIMAISIPHILGGTYVVEKVFSYPGLGTLCF
                     ESAKYHDYNMLLVLCLITGALVVFGNMLAQIINNKIDPRMKYDRGDTNEATI"
     gene            38262..39173
                     /locus_tag="KRO40_000927"
     CDS             38262..39173
                     /locus_tag="KRO40_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091758.1"
                     /translation="MKPQYSDFEIVGENYILVAEDEHIETKKTLSKKIKELPYISIII
                     LSIIVIGSVFSSFIMTHEPTYMDLASSNLAPNKTFLFGTDSMGRDIYSMIWYGGKISL
                     FIGLFSTVISTVIGIVYGSISGSASELVDDAMMRFTEIILSIPSILIIIFVQAILGNS
                     NPVSMSIVIGITSWMNISKIVRTEVRQIKNSEYILAAKSMGGGFFYVLKQHLLPNFVA
                     SIMFMVVTNIGAAIGTESTLSFLGIGLPIEIVSWGSMLSLSEEALLSNRWWIILIPGI
                     FLVTTLVCITNIGNYIRKNNNKKSSNL"
     gene            39286..40854
                     /locus_tag="KRO40_000928"
     CDS             39286..40854
                     /locus_tag="KRO40_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2091759.1"
                     /translation="MKLKKLKVLSLVMILSLMAGCSSGGDKDKKADTPKDGKVLVYGS
                     NDYTSINPALYEHGEINSLIFNGLTAHDENNKVVPCLAKDWKFDEATNTYTFNLRDDV
                     KWHDGEKFTANDVKFTIETIMNPDNASEIASNYEDITKIDVVNDNTIKITLKAPNTAM
                     LDYLTVGVLPKHALEGKDIATDEFNQKPIGTGPFKLEKWDKGQSITLVKNSDYFVKEP
                     GLDKVVFKIVPDDKAKAMQLKSGELDLAQITPKDMSNFEKDEKNFKVNIMKTADYRGI
                     LYNFNSKFFKDKKAKGLPNALSYAIDRKAIVDSVLLGHGVPAYSPLQMGPYNNPDIEK
                     FEYNPEKAKQEIEKLGWKLGSDGIYEKEGTKLAFEITAGESDQVRVDMAKICAQQLKE
                     IGVDAKAVVVTETDWANQDAHLIGWGSPFDPDDHTYKVFGTDKGANYSAYSNPTIDKI
                     LQKARETEDKDEKLKLYKQFQVEMTKDMPYTFIAYIDAIYVGKPNIKGLTPDTVLGHH
                     GVGIFWNIADWTIE"
     gene            40929..41954
                     /locus_tag="KRO40_000929"
     CDS             40929..41954
                     /locus_tag="KRO40_000929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091760.1"
                     /translation="MEHLLEVNNLSVSFKVEEGEVQAVRNVSFNLKKGETLAIVGESG
                     CGKSVLCKSLMRILPYNGYIKNGEVLLKSSDLVKKSEKEMEDIRGKNISMIFQDPMTS
                     LNPTISIGKQIAEAVIIHQGISKSEAKKRAIELIELVGIDNPEKRFKQFPHHFSGGMR
                     QRIVIAIALACNPDVLIADEPTTALDVTIQAQIIDLIKDLQHKIGLSIIFITHDLGVV
                     ATIADRIAVMYAGKIVEIGTVEDIFYDPRHPYTWGLLGSLPTLDSQDDYLYNIPGMPP
                     NLLNPPKGDAFAIRNKNALKIDYEKEPPMFKINDTHSAATWLLHPDAPEVDVPVRVNC
                     GRVISNE"
     gene            41947..42891
                     /locus_tag="KRO40_000930"
     CDS             41947..42891
                     /locus_tag="KRO40_000930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009527644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091761.1"
                     /translation="MNREKILEIKNLKQYFHLDKSTTVKAVDDISFDIYKGEIFGLVG
                     ESGSGKSTTGKTIIRLHESTGGEVIYKGNCISDKKTYKFIKKDVNKSMQIIFQDSTSS
                     LNPRMTIADIISEPLKIQGICKNKTDRMNKVYEMLKLVGLDRSYANKYPSDFSGGQRQ
                     RIGIARALSVDPEFIIADEPIASLDVSIQAQIVNLFKKLQQEKNLTCLFIAHDLSMVR
                     HISDRIGVMYNGKLVELADSNELYNNPIHPYTKSLLSAIPVPDPRYAKSRNRIEYNSN
                     GYDCSNEKSLSWIEVSDGHFVYSSKSEINKYQQNLKVV"
     gene            43250..45907
                     /locus_tag="KRO40_000931"
     CDS             43250..45907
                     /locus_tag="KRO40_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2091762.1"
                     /translation="MIYKKDKVMKVLESSYRENEKGITANQLSEKTGIARNNISTYLN
                     QLFNEGMVTKIKGRPVYYIPANLNLNKNELLDTQSELLGIKKGTKVENKIKKDSFETL
                     IGKEHSLRPIIEKCKVAMLYPTNGLHTIIYGETGVGKSMIARYMYDYSIDSGIRKNKA
                     PFVTFNCADYANNAQLLMGHIFGVEQGAYTGAESSRKGLLEIANGGILFLDEIHRLPA
                     EGQEMLFTFIDKGTFKRLGDATKERESKVLIICATTENPTSTLLDTFNRRIPMKIEIP
                     SLRDRTMIERMELVKNFFKEESKSISISIKVHKEIIKSLLLYDCKNNVGQLQNDIKLA
                     VANGYLRYKRDNKEPVYIEKKYFDKSINEVSDDYREKSIKADEVITHGIEYFVFTSLG
                     EEEVINYNDINIINAVNTNLNKSVEMNIADASLFNNVKFKSMCESIRQIIKEDEEIDI
                     SESIFKSMAIYIKSVLDKSSSTNNIDLNQIRRNNRSEFKTALKIVGIIENEFDLFLSI
                     ETVAYITLFIVQAKQDEQNKIVNNINIIVAMHGETTASSMVKAVGDIIGKCSAISFDM
                     KLDKSYDEVIVDFKNLINNIDNKDVLLFTDMGSLNSFDEIIKKEKKCGVRVIPMVTTL
                     TVLEAVQKANMGLPLNDVYNSITNTRKYYFGTNEIQNKENLSKTIIIASHVSEGVDNK
                     TRKILEEKMSRYLDGIDIISVPYKTEKDLSLNITKLKESSNIVAVINEQRINIRGIDY
                     ISKKDIDKDENINKLKNIIKISIGYDDVVEGLKTSLKSSNYNRIFKGIKYVSDELFLV
                     FNIEKKYDKVIGLMMHLAFMVDGLIGNTREIEKLDKEKTLDYHKSLSKIKDIVSQLDK
                     KYNIEINEKECYQILLILEYAEIIEKDYQ"
     gene            46122..46751
                     /locus_tag="KRO40_000932"
     CDS             46122..46751
                     /locus_tag="KRO40_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091763.1"
                     /translation="MQDKILRDKKANDPWARMTTRNGFSADEIISSFQKAIRRNMVEE
                     ACEFAYELYISSPELEDKLWRRILTISVEDIGMGDPSAVIIINNLNQVRKEYSYADGD
                     RPLFFIHAIRYLCACEKDRSSDLLKNIIIKGFAMGKVPEVMDVALDKHTYRGLEMGRD
                     SFHFLNEASIVIPEKEVDNDYKERYLKILEKYKQEEVIDTAFKFNHWQY"
     gene            46886..47212
                     /locus_tag="KRO40_000933"
     CDS             46886..47212
                     /locus_tag="KRO40_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2091764.1"
                     /translation="MNILLVCANGASTGVLVEKMKSFCSEHEKLKTKTINIEATSFEN
                     LKSYIEANDTDVVLVAPQIRFKEDDVVEACKNYKIAVGLIDTKHYGRMDAPSVMKSAI
                     ELYKNR"
     gene            47228..48517
                     /locus_tag="KRO40_000934"
     CDS             47228..48517
                     /locus_tag="KRO40_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2091765.1"
                     /translation="MEALQNNLRRFLLPIAQKIEKQRHLQAIKEGMISITPIIIVGSL
                     SMLFMALNNMLPEGSAKTLLSENMDTLLIPNKFTMSLLSIYSAFFIAQALAKKYNLNH
                     VEIGMTAVVAQLVVCGQVVDGVLDTSYLDAQGLFVSILVALLVVDITKFMNDKNLVIR
                     FPKEVPSVVNKSFRNLTPMIVCIMLFTAIAAITKNVSGQPLPAIIMNFLAPAISSVDN
                     VFAVTIILFITQLLWFFGLHGAAITSSIWMPIAATYMAENATLIAAGGDPKYVFTIGF
                     YYGFLQVTGSGITLGLVYLMSRSKCKSFNSMGKVVILPSLFGINEPVIFGTPIVMNPY
                     MFVPFVFGPVLVGALNFMALKVGLVGLPIAEPPGFLPPGVAAFLMTLDWKAIVLVFAS
                     IILMTLIYYPFFKIMEKEELNKNAELATTLDDDSFDF"
     gene            48541..48870
                     /locus_tag="KRO40_000935"
     CDS             48541..48870
                     /locus_tag="KRO40_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2091766.1"
                     /translation="MVPEMEEKVFSIISEAGDAKSDVMMSLKEIKKGDYNKAKHLLNS
                     ASEKIQTASKHHLELLSNAMNSEDSGTDFLVVHSEDHYSNALFAHSLVSELVDIFEMM
                     DPRINKN"
     gene            49018..50346
                     /locus_tag="KRO40_000936"
     CDS             49018..50346
                     /locus_tag="KRO40_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH2091767.1"
                     /translation="MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEER
                     QNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDFCLAHIRVGKLEMRELDEKIPLK
                     HGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
                     PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPK
                     LVEHIKEYGFINGEEGMKNDKKDSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVV
                     NHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIHAEFIVDLATALAFN
                     TQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVE
                     KLVVDAWIEKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN"
     gene            50663..51523
                     /locus_tag="KRO40_000937"
     CDS             50663..51523
                     /locus_tag="KRO40_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-ADP-ribose hydrolase"
                     /protein_id="HBH2091768.1"
                     /translation="MAMKWRDYADDVNLFEDFDKTIKPLTDEQRRKNINTLIAYFSKE
                     VPSKIYNLSNDEIKPRDILRGLLNVYPPKEIAPEILNMLHNLLLIECEERELIDVNDI
                     EEVEEGIAIWRGNITNLRADAIVNAANNKLLGCLQPLHLCVDNEIHSCAGPRLREDCD
                     KIIKKQGHLEYTGDAKITRGYCLPAKFVVHTVGPIVSGGQPSKEQEKQLLHCYKSCLN
                     TIKEIDEIKNIVFCGISTGVFGYPKKEAANLAVSRVRLWLKENPEKNLKVVFNVFTEE
                     EEEKYRRIFK"
BASE COUNT        19845 a         5720 c         9263 g        16733 t
ORIGIN      
        1 tcaaaataaa taacttatgt aagaaccgta ggaactacgg ggatagcctg tggagaatta
       61 gtaagacata ttttagtatg caaaattctg tgaagcagga accctgtgac tttagtcatg
      121 ggaggttcag tttgggcaag tagtttcttg taaatctagt tatgtttcaa ccaatgataa
      181 tataatttca ttagtattag ctggtaatta agttaatttg actagagata agtaaattga
      241 tttaaaagga aataagtaaa tcaacaatta aatacatcta aaagtaagtt tattgcaatg
      301 aattgttaaa gaaaataatt aatatggagt aaatctattg caatgaagta acaaagaaaa
      361 taattaatat agagtaagtt tattgtaatg aattgttaaa gaaaagagtt aatatagagt
      421 aagtttattg taatgaattg ttaaagaaaa taattaatat agggtaaatc tatctcaatg
      481 aaataacaaa gaaaagagtt aatatagagt gaacttattg caatgaatca acaaagaaaa
      541 taatcaatat aaaaaggaga aatatttatg aatacaggat ttccaaaaga ctttttatgg
      601 ggagcatcat cttctgcatt tcaagtggaa ggagcttggg ataaagacaa taaaggaaaa
      661 accgtagccg actataattc ttttaaaaag tctcatttac aggcagatac taaagtcgca
      721 tcagactttt accataatta tgaagaagat attgaattaa tgaaagaatt agggatgaaa
      781 acatatcgtt tttcaatttc atgggcaaga ataataccag atggtgaagg agagataaac
      841 cagaaaggtt tagactttta taataagata atagacaaac taatagagtg tgatattgag
      901 ccattcgtaa ctttatacca ttttgacctt ccatttaaat tagtagagaa atataatggt
      961 tgggaaagta gagaaactgt ctatgctttt gaaagatttg ctaaaatatg ctttaagcat
     1021 tttggagata gggtaaagta ttggcaacct cataatgaac agaatttaat tgttagagtg
     1081 gaggagagaa ttaatatata tgatgaaaca gattcatgga agatagataa aatgcgtgct
     1141 cagatggatt ataatctttg cttagcacat gcattagcag tcaatgcatg tcatgagatg
     1201 ataaaagaaa gtaaaattgg agcagcagta tcatcatctg taacatatcc tcttacttct
     1261 aagccagaag atgtatatgc agctagaatg aatgataatt ttaaagtgta ctatatgctt
     1321 gatatgcatc attatggaga atatccaggg tattatatga agtatcttga aaaaagaaat
     1381 atagttcctc acatggaaga tggggataaa gagatactta aaaaagctaa aatggatttt
     1441 atagctgtaa attattatag gacaaattgt gcagaagctt tacctgaaga ttcacaacat
     1501 ccatttggat taagagaagg aactgttgat tttagtatgt atggactatt taaaatgtca
     1561 atgaatccta acttagaggc ctctgagtat ggagcagcaa tagacccatc aggtcttaga
     1621 gttgccttaa atgaatattg gcaaagatat cacttacctg ttataataac agaaaatggt
     1681 ctaggagcta aagatatatt agaagatgga aaaattcatg atgactatcg tatagactat
     1741 ttaagaagtc atataaatgc atgtaaacta gctattgaag atggtgtaga gatgattgga
     1801 tattgtccat ggtcatttac agacctttta agttcttctc aaggttttaa taagcgttat
     1861 ggacttgttt atataaatag aactgaccat gaagttttag atttaaaaag aatcaagaaa
     1921 gatagttttt actggtataa agaagttata gagaacaatg gaatagtaaa ataaacataa
     1981 atatatattg agggttttag tatgtacatt acaaaggtat taaataattc gttgctactt
     2041 gcaaaggatg ataatgatga agaaataata ttgatgggga aaggcattgg ccataattat
     2101 aaggccgggt ctgagttaaa taaaaaagat atagaaaaga tttttgttct tcatgatgaa
     2161 aatataaaaa agagcattat acaattggca acagaaatag atgcagaata ttttggtata
     2221 gctcaaatga taattgcata tggaatagaa aaatataact taaaacttat gaaccatata
     2281 tatttggcct taactgacca cattgccttt gcagtgagac gttttaaaga aggtataatg
     2341 attgaaaatc actatttgtt cgaaatcaag gaatttaatc caaaagagta tgatatagga
     2401 aaatatgcta ttactgtttt taaggaggtt cttggtttag acctaccaga agaagagatt
     2461 ggtaatatag caggccattt tataaatgca caacaagata atccttatag tgatagaaat
     2521 aagagaagtg ctaaaattgt aaatgctatt ttgcaaatag ttcattatca cttttctatt
     2581 gtatataata aagagtcatt ttattatagg agatttgtaa tgcatctaaa ggccttttca
     2641 caaagatttc tggctaatga accatcaaga gaaaaaatag attttatata tgagcaagtt
     2701 caaaaaaatt gtaaggaaga gtatgaatgt gtgaaaaagg taggagctta tatgtataag
     2761 gaatactcca gagaattacc aagacaagag gagttatatt tgatgattca tattcataag
     2821 attttaggag aattatgcga aaatagttag aatatcttaa tatgctagta atattataaa
     2881 aaattaaaaa ttaactacac tttaaatatg aataattgca ttacttaagg gggttgtctt
     2941 aaaattgatt tttttaatta aatttgaagc tcaactcctt ttttaaacct ttatatcatt
     3001 acaactttaa tgtttatacg cctgtacttc agatgtatat ctacttttta catttctcaa
     3061 catgcaaatc taccattttt tgcagtatgt taattgaaat aaaccattga gttaacccta
     3121 aatttattct ggacttatag gaatagttcc aaagatactt taaaatattt tctggaataa
     3181 ttgcttattt cacatatgtt ttattgtgat gttttgattt aataaattct tcaactctgt
     3241 atatagtaaa tgtattatca tgtttgtttt attcaagcac acttataata cgcttgattt
     3301 tttcacaatg atgaaatata ctaatgggtg ttataagtat aagaatagca ttacacttga
     3361 agaagcaagt gataaatgag gtataaatcc tcatatgata aactactatt tcattgagga
     3421 gcatattcta aatgatgtaa agatactaca atatgactaa attcctaatg ataaaaaagt
     3481 ctacgaatga gtgtagaaag gggaactaag atgaataaag ttttaattat agatgatgat
     3541 aaagatcttt gtattttgtt aaaaaagagt atctcaattg aacagattga agcaaactat
     3601 tgccattctg ggagagatgg actggctgaa ctttcaaaac aagattatca gttagtagtt
     3661 ctagacgtga tgatgccagg tatggatggt tttgaaacta tggaacaaat acgaaaatat
     3721 agcagtattc ccatcttaat gctgacatca aaaagcgata attacagcaa agtgcatgga
     3781 ttgcgagctg gtgcagatga ctatctaacc aaaccatttg aaattacaga atttactgct
     3841 cgtgtactgt ctttaatccg acgttacacc cgttttaatc caaaaaatga ggagccacag
     3901 caactttctt tcaaaggttt gttgattgac cttgaccagc atacagtgac taccaatggc
     3961 gaacctatgt tgcttccacc caaggaattt ggtgtgcttc tttactgtgc aaagcatcag
     4021 ggtaagattt tgacaaaaca gcagatttat gaagccgtgt ggggtgagcc atatgtatat
     4081 gatgacagca atatcatggc tattatcagt cgcctaagaa aaaaaattga actagaccca
     4141 tcatctccca tctatttgca aacaataaaa ggaattgggt atcaattcaa cacggaggta
     4201 tgaaaatgga cgaacaaacg ataattcttt tcttactctt gctgtcgatt ggtctacttt
     4261 ttctttccat atttgctttt tccaagcttg ggcatattta caagcgccta aaagatatag
     4321 aggagatact ggctgatgta caaattggag acgaaaatcg taaaatacta attaagccat
     4381 gtgatgttat ggctccattg gtttatcagc ttaatgagat tgtctacgat tatgaaaata
     4441 agttactttc tctgaaaaag tcggataaag ctagcaaaca acttatgaca agtttatctc
     4501 atgatgttcg tacaccatta acaactctga ttggttatct ggatgctgta cacagtggta
     4561 tagttatcga acaagaacga gaggaatacc ttgaaatcgc taggcgtaga gcctacgacc
     4621 tcaaggatta cattgatgtt ctttttgact ggtttcggtt gaactctgat gaatttacgc
     4681 tgtcaataga atctgtagaa attgcagagt tgtcacgcaa tattttgaaa gactggattc
     4741 ctatattcca tgaaaagaaa ctgaattttg aaattgatat tccagaaaat cgactaatgg
     4801 taaacctcga cccagatgga tattcccgtg tggtcaataa tctggttcaa aatgttcttg
     4861 ctcacagtaa ggctcggcaa atcaagatta ccatgagtga ggattccaga atggtattac
     4921 tccgtgttga ggatgatggt gttgggattg ccagagaaaa tttaccacat atttttgagc
     4981 gactgtataa gtgtgataaa ggacgttcag aaaaaggaag tggtcttggt ctatctattg
     5041 tcagtcaaat ggtggagcga atgggtggtc agatttccgt agaaagtgag attggaaagt
     5101 ataccatatt tacagtgagc ttaccattaa tataaaattg tttttccccc atgtgacatg
     5161 tatacacagg gggatttttt gtaagttata aagttgcaag gttaatacaa ggttgttgca
     5221 aggttaatgt aagattgagg tggtatgata actttaataa acaaaggagg cttttattat
     5281 ttatgaataa tttaattatt gaaacaaaaa atctcactaa gcaatatggt gctcaaaaga
     5341 gcgtttctaa tttgaatatt cacgttcaga aaggtcgcat ttacggattg ctaggaagaa
     5401 acggtgcggg taagacgaca actatgaaaa tgttattggg tctaacaaaa ccaactactg
     5461 gagaaattaa aatatttggt caggacattc acaataacga gaagaagctt cttcctcgaa
     5521 ttggatgttt gattgaatca ccagggtttt atcctaatct gacaggaaca gaaaatctca
     5581 aaatctttgc aaggcttaga ggaataccaa aaaaaaatgc agtagaatca gcactggatg
     5641 tagtcggttt gccaaacaat gacaaaaagt tattttctca atactctctt ggtatgaaac
     5701 agaggttggc gattgctctt gccattatgc atgacccaca actgttgatt ttggacgagc
     5761 ctatcaatgg gcttgatcct attggtattg cagaagtaag aacatttatt cgtgatctct
     5821 gcacagagcg aggtaaaact attttgattt ctagtcacat tctttctgaa attgccttgt
     5881 tggcagatga cattggcatt attgaccatg gtattttgtt ggaggaagaa agtcttgccc
     5941 aattagaaga aaaaaacagt aaatacatac attttgctgt atctgatgca gcacaggcag
     6001 caaggcttct ggaaacccaa cttaacctga aaaatttcaa agtagcagat aattacaata
     6061 ttatgctata tgatacagat gtttctgttg cagaaataaa tcgtgctttc attctaaaca
     6121 acattgaggt atcagaatct catttatgcg aagatactct tgaagattac ttcaagaaag
     6181 taacaggggg tgaaggaatt gcttgatata atttcatgtg aattttcaaa actcaagcgg
     6241 ttaaaattta tactgatttc tattttaggt gcttgcttat ttccaattcc cgcaacaatt
     6301 ttgattgcaa aggataactt gccctttgag caattgttca aattagttgt caattttgga
     6361 tattttttgc tattaccaat tgtattaagt attgttgcta gccaactatt ttttatagaa
     6421 agagataatg atgtattaaa aaatcttgca acagtgccag tgcaaaaagg aaaactggct
     6481 ctggcaaaat tggctgtgtt gctgtttata tcattgttct actctgttgc agggttagga
     6541 gctactatca ttggaggttt cattgttgga atagtagagg gggttgctgt aaaattagga
     6601 atgagcattg cttttggaat tatgtttttt gttactgtac ttcctgttgt ggtactcatt
     6661 gtatatttca atcgcagcta tattttttct attatacttt cttttgtata tgctattttc
     6721 aattttagta tatccttaaa tattatcaat tttgaaccaa ataacccaat attaagtgta
     6781 ttacctgctc ctgttataat gcgttggtgg atggcatttt ggggagatcc cactggcgaa
     6841 tacacggcac ttagacagcc atatttgctc tcaactcctg cttgtgtagg tattttatgt
     6901 ttgataacca ttatagcagt cctgctgatt tgtatgatat acaaaaagca ggagaattag
     6961 gaggtatcta tgcttgatat aattactaca gaatttcaaa aaataaaaag atataatatt
     7021 ctatggattg gtgttgttgc tgttctgttt tcagcactat tggcagtttt tcaggttgta
     7081 agttcacacg gcagtgaccc tctaacgtat gagagctttg caaacggagt tatctggaat
     7141 aatttcagtc ttagttttcc atttgggatt acacttattg gaggatatct tattaaccgt
     7201 gaatatacag accaaacctt aaaaaacatc ctaactgttc ctatttcatt acgcaaattg
     7261 ctagtgggaa aattaattgc ggttggagga attactgtat tgttaagtct tttcagcttc
     7321 ttatgcacat ttattttggg gttgttattt tgcaatatta atatatctgt tacactcgtt
     7381 gtaaaatcct tagttcagat tttgtctgtt aatctgtact gttatgttgc tgttttgccg
     7441 attattgctt attttggtcg taaacaaaat gcatttctga cgggtgtagg gattgcattt
     7501 gtatacggtt tttgtggtgt gtttgttgct ggaagaaatc tgacagactt ttatccaatc
     7561 acagcaggtc ttggtctagt tggatacaac aatggtgctg gtactgttta tcagccactt
     7621 attggtgcta tgactttgat tgtaattcta atcttgacaa ctattctact tgtatttaca
     7681 cctaattatg ataaagttat gaccatatct aagaaaaaag ggataaagca taaaaagtat
     7741 tctcataaat aacataaata ttgtttctat tatttaagtt gctagacagt gaaaagaaaa
     7801 aatctgtcgt acagtggcta tatgctcatg tattcaagaa gctacagttt tgatttttca
     7861 taactgtagc ttctttttgt atttattaaa tcacgactat cataatactt gcaataggta
     7921 tagcgacaag agagagtact gtcatatgtg ttttatatat tacattaagt atattctaaa
     7981 atatatgttt taaataatat atttgaaaat aggaatattt aaataaaaaa aataatatta
     8041 tatatagttg acaaaaattg gcaaatgata taatatataa atatagaaat agtaatcatt
     8101 actattatta aaagggagga attaattatg aacttaaaag gaactaaaac agaaaagaat
     8161 ttaatggcag gatttgcagg agagtcagaa gcaagaaata aatatacata ctacgcttca
     8221 aaagcaagaa aagaaggtta taatcaaata gctgctatat ttgaagaaac tgctaacaat
     8281 gaaaaggaac atgctaaatt atggtttaaa cttttacatg atggtatgcc ttcaacagag
     8341 gaaaatttaa aggatgcagc agcaggtgaa aactatgaat ggactgatat gtatgcaaaa
     8401 tttgctaaag aagctagaga agaaggattt gacaagatag cttatttatt tgaagctgtt
     8461 ggaaaaatag agaaagagca tgaagaaaga tacttaaagc ttttagaaaa cttaaatgaa
     8521 ggaaaaatat ttaaaagaga tgaagaagtt gtttggcaat gtcaaaactg tggtcatgtg
     8581 tatgtaggta ctgaagcacc agaaaaatgc ccagtatgtg accatccaaa agcatatttt
     8641 aatataaaag ctgaaaatta ttaaaaatta tcattattaa aaaggaatgt taactatgaa
     8701 attttctaaa caacgagaac tgattttaaa tgaaatatta aataatccgg ttcatcctac
     8761 tgcggattac ctatatgaaa acttaaaaaa agataatcca aatttaagct taggaactgt
     8821 gtatagaaat ttagctcagc taacggaaca tggctttata agaaaggtta gtattccagg
     8881 atatccagat agatttgatg gtcgaataga taatcactat catatcatat gtgaagtatg
     8941 tggagaggta tacgatttag aatccgaagt tcttaataat ttacaagaat taatatctga
     9001 ggagacagac ataaaaataa catcttataa cataagtttt aaagggattt gtaataattg
     9061 taaaaggtgt agccaagtag gttagttttc aaattctaaa aataattaat gaggtgagtt
     9121 tatgtgtagt gaacaaaaat tttttatatg tgagacttgt ggaaaccttg taggaatgat
     9181 acaaagtggt ggtgtaccta ttttctgttg tggaaaacct atgaaggaac ttgttcctaa
     9241 tacaacagat gcagcagttg aaaaacatgt acctgtaatt gaagtggatg gaaataatgt
     9301 tactgttaaa gtaagtagca caactcatcc aatgactaaa gaacatcata tagcatgggt
     9361 gtatcttatg actgaacaag gtggtcaacg caaatgtcta gcagtagatg gagaacctgt
     9421 agttaaattt gctttgaatg atgatgataa agtgatttct gcctatgctt actgtaattt
     9481 acatggatta tggaaggctg aactgtaata tttaaataaa ttgagtcaaa aaggaggcta
     9541 taaatgtatt ttcatacaaa tagcctccta taaatttata taaattcaag ttttaatttt
     9601 gtttaatgtc aatataatat aaggagaaaa taatatgtca atttataaat gtagtgtttg
     9661 tggatatatt tatgatgaat ctaagaatga taaaacatgg gatgaattaa gtgaagattg
     9721 ggaatgccct gtatgtacaa aaggtcgtag ttattttgga aagataagta ctgtttacta
     9781 tgaagaagat gaaaagatag cagaagacat agttgaagat gaatctaaat taaatactga
     9841 aaaagaggga gatttaaatt acttaagtac atatttaaga agagatgatg aagttgagaa
     9901 acatatggat ataattcacg aaatggctgt tacaggaaaa tctataatag aacctatgag
     9961 aactaaacta ccagtaattt cttgggatga tattttaatt atgggtgctc aattaaatcc
    10021 attaccttta aatgagcatg atgaagtaaa tacaacaaca ataataggaa aaaaagcaaa
    10081 gaaacctatg attatagaaa atccagttta tatttcccac atgtcatttg gagctttgtc
    10141 taaagaacta aaaatagctt tagcaaaggg tgcagcccaa aataagacag ctatgtgtag
    10201 tggtgaagga ggtatattac cagaagagaa ggaagcttca tacaagtata tttttgagta
    10261 tgtaccaaat aaatatagtg taactgaaga aaatcttaaa aattctgatg ctatagagat
    10321 aaaaattggt caaggaacaa aacctggtat gggaggtcat cttcctggcg aaaaagtaac
    10381 tgaagaaata gcaaaagtaa gaaataagcc tgtaggtcaa gatgtaataa gtccatcttg
    10441 ttttgaggaa atacaatcca aagaggattt aaagaaactt gtagatgaac ttagagaagt
    10501 ttcagaaggg cgtccaatag gtgttaaaat ttcagcaggt catattgaaa aagatatgga
    10561 atttatagct tatgctaaac ctgattttgt aactattgat ggtcgtggtg gagctactgg
    10621 agcaagtcca aagttgctta aagatgcaac ttcaattcca acaatatttg ctctttatcg
    10681 tgctagaaaa tacatagata cacatggatt agatatagat ttggttataa caggtgggct
    10741 tcgtatatct actgattttg ctaaggcaat tgctatgggg gctgatgcag ttgctattgc
    10801 aagttctgct cttatggcag cggcgtgtca acaatatcgt atatgtggtt ctggtaagtg
    10861 tcctgtagga gtagctactc aggatgagga attgagaaaa agattacata tagaaaacag
    10921 tgctaataga gtggcaaact ttttaaatgt aagtttagaa gaacttaaga cttttgctag
    10981 aacttctggt cataaagata tacatgattt aagtgttgat gatttatata ctgttaactc
    11041 tgaaatatca aattatacaa acatacagca tgtatagatt gaagtttgaa actattagat
    11101 tttagatagc tataaaagta aatgataaat atattttata aaagagagtg tcttaaaatg
    11161 aactttttag ttcataagtc actctttttt ttatgaagcc aaatatattt atcattttag
    11221 caatgaaaaa gaatcttatc tctttatttt gagatagatt ccttctattt atgaaaatta
    11281 aagatattaa attgtaaaat attctgtgat gtcgtactat taaactaaag attctgtact
    11341 ttaaagtaaa taaaaattta aggagtgatt attatggaaa gattgaagat acaagtttta
    11401 gtcgacaata atacttatat tgatagatac tttgttggag aaccagcagt aagctattat
    11461 attgagattg atggaaatag gattttgttt gactcagggt attcagatgt attcatatca
    11521 aacgctgaaa aattaaatat agatttagga aatttaactc atgttgtttt ttctcatggg
    11581 cataatgacc atacaagagg tatccagttt ttagaaaata ggtatgattt atctacaatt
    11641 gaacttattt cacatcctaa ctgttttata cctagaaaac atggagagaa aagcatagga
    11701 gctccatttt ctgctgagga aattaaaaat atttttatgt ataatcctaa ggataagcca
    11761 tttaatctaa gcaagaattg tgtgttttta ggtgaaatac cttctataaa tgattttgaa
    11821 aaaagagcta aaattggtaa atgtaaaata ggagatttgt gggaagatga ttatgtttta
    11881 gatgattctg ctatagtttg taaaactgat aaaggtattt ttattattac aggatgttct
    11941 catagtggaa tttgtaatat agtagagtat gctaaaaagg tatgtagaga tgatagagtt
    12001 attggtatac taggtggttt tcatcttttt gaattgaata ataggttaga tagtacaata
    12061 caatatttgg ataaagaaga aataagaatg ttgtaccctt gtcactgtgt ttcttttaag
    12121 gtaaaagcga agatgaatga aatattgaat ataaatgaag ttggagtagg gctgaccata
    12181 agtatatagt atttgaaagt atataagatt taagttgaag gttaaaaaga tattttctat
    12241 agaaaatatc ttttttgtta cgtttatttt aagagaaatc aatatacttt tatatgaaat
    12301 attgtaaaaa aatttatttt taatgagaat atattttcat taataaacaa ttttattatg
    12361 tattaataat gttacaataa atataaataa atcaaagtta cttacattac agtatatttt
    12421 ttcacaaaat atattgattt attcttttaa agtttgataa ttccaatgaa tgtaataaaa
    12481 gaagggattt tatactatat gattattatt ataaaataat aaagaaaaaa ttatataata
    12541 ataaagaaaa aatgtataat atttaacatt aaaaaagata tttcataaaa ttaaaaaaca
    12601 aagtgaattt gaatactatt taaaaaataa aataaatata taaaaaatat ttaatataaa
    12661 ggtagaaata agttgaaaat gtaaagtcat tggaaaaata tagttgaatt taatgagcaa
    12721 aaatgttatt gttttatcaa taaagtgtta aaataaaaac ttttaatatc attttaggga
    12781 ggatgatttc atgcaaaaaa gtgtaaagaa agcaaaagta acgggctcta tgttagccat
    12841 ttttggtgtt gcaagcgttc tttttagttc acatgcagga ggaggatttg ctacagggaa
    12901 tcaagaaact cagtactatg tgcagtatgg atggacagca ccacttatgg caattttagc
    12961 aatgattata cttactgcta ccatgagaga agttatcata atgtataata ataataattg
    13021 taggaattat aaggatttat tttgtgagct ttggagacca tatccaaaac ttgaaataat
    13081 atgggagata tattactatc taatggtttt aatagctgta agtgctgtta tagcaggtgc
    13141 agcagcagta tttcaaagta taggagtaaa ttattttgta gctgtattta ttattggagt
    13201 tgtacttctt gtctttacta tatttggtgc tatgcttgta tctaaagcag ctacagcaat
    13261 gacaatagct attctagtat gtactcttac tatttttatt gttggtataa aagctaaagt
    13321 accagaaata actgaaatat tatcaaatag aacgagtttc acacctggct atatcaagcc
    13381 aatacttaat acttttattt atgcaggttt tcaatcggtt gttataccta cacttgcagg
    13441 atgttcaaga ccacttctta agaactcaaa agaagctact aaggcaatga taatttcatt
    13501 tgttatgaat gcaattgcat taggacttgc tgtaactatg ctaatgggat ggtatagaga
    13561 aattattgct gctgggcaaa caacactccc tactctttat gttgcaggtc aatctggaaa
    13621 tcatactata tacataattt ataatgttgc attattcctt tgtttaatgt ctacaggagt
    13681 aactactata tttggtcttg taaatagatt tgaagaccat aaagcacttt ctttcctttc
    13741 ttcaagaatg aaaagaaggg tatttacagc ttgtgcaata atggtagtgt caatgcttat
    13801 atcacttaca ggattaagta atattgttaa atatggatat ggatattgtg gttatcttgg
    13861 tctattcact atagtaattc cattccttac actaggacat tataagaata agaagtttgc
    13921 aaaggaaaat ccagaagcta aatggccagc ggaattaaat gaaaatgtaa attagatgta
    13981 gtagcaaaaa atattgctaa agagaatact atagataaga atactataga taatatatct
    14041 gcatgtttat taagattatt tgcaaaatct aatattaaac aactataaac aagcaatata
    14101 aaactaagaa taaaagataa aaagagggtg tctcaaaatg gacttttagt ttataaggca
    14161 ctctttttta tatgaagtca agtatatttt cattattttg acaataaaag agactaatcc
    14221 tactttggat agcctctttt ttctttaata taaaatagta taacagcaaa gtatagattg
    14281 atacatgttt tctgtagctt tctatatatt acagtgtttg tgtggcattg gtattttaag
    14341 caatctataa attataattc tataattctt ctactaattt tagattctat agccgtctct
    14401 atttcactta acattcgttc atttttaggg tcaataaaag cacatgtata tccttcttca
    14461 ccagctctac cagttctgcc aatacggtgg atgtagtctt ctggtgtttc tggtaaatcg
    14521 taattatata tatgacttac tccagatata tcaagaccac gagaagctac atctgtagct
    14581 attaagtatt gtatatctaa acttctaaat gatttcatta ttctttctcg ttttgattga
    14641 gcaatatcac tatgaagttt ttgacaatta tatcctctta tagcaagagc ttcttcaaga
    14701 tggtcaaccc ttctcttagt tctacaaaat attattgcca taaaaggatt atcttcatct
    14761 agtaccttac ataaggcatc taattttttt ctatctgtag tttctactac ttcttgtttt
    14821 atattattaa gagtgatttc ttctttttga atagaaacta caacaggatt ttttgtgtat
    14881 ctataagcta atttttttac ttgagaattt atagttgcag aaaagcatag tgtttgcttt
    14941 ttgtttgaag tctcttttaa aatagcttcc acttcatttt taaatcccat aagcaacatt
    15001 tggtctgctt catctaaaac aaaagtcttc aacttactaa ggtctattgt ttttctattt
    15061 agatggtcta aaagcctacc tggtgtagct ataatcatat gaatatttcc ttttagtttc
    15121 tttatttgag aaccaatatc ttttcctcca tatgctgcaa gaatacttac atctttagat
    15181 tctttaagtt tcatagcttc ttctgttatt tgaatagcta gttctcttgt aggagaaagt
    15241 ataagtactt gtatatcatt tatatctaat gatatatttt caaatatcgg aagtaaaaaa
    15301 gctagtgttt ttcctgttcc agtttgagct tctgctatta catcttttcc ttcttttatt
    15361 agtttaatac tttctttttg tataggtgta ggtgttgtta ttcctaattt ttttagaata
    15421 tttattgtat tttcactaat ccctaagctt ttgaaatcca ttgttatctt acctttcatg
    15481 aaaaattttc ttttttatta accaattaat aatatcatat ttgtaagtat ttttagtaaa
    15541 ttttttaatt attatttata tagcttaaaa atatattaag atactttaaa atggaatgta
    15601 acttaaatta aattttagta ggaattttat aggtttattt ttaaaggttt tttgaaaata
    15661 aatctattta aaaattaaat taaaatgcaa gaaaaacata ataactttca tttttaagaa
    15721 gttttcacaa aaaagaaaaa atatagtgca ataaatgata caaagtaata taatagatta
    15781 caagatatga aaagctaaaa aaataaattg caaatgaaat taaaatgaat aaaaaataaa
    15841 aaaataatca taagttagag gtatcaatga aaaataagac ttaatgtttt taaaattaaa
    15901 agtatactaa ggggggcatt aatatgtgcg ttatatcaaa agatagagca aaggaaataa
    15961 aaatagtaga tactacttta agagatggag agcaaacagc tggggttgta tttgcaaata
    16021 gagaaaaaat aatgattgct gaaatgttaa gtgacctagg tgttgaccaa attgaagttg
    16081 gtatacctac tatgggtgga gatgaaaaaa atgtaataaa gcacatatgt agtagaaatt
    16141 taaaatcaga tataatggct tggaatagag cagtaataaa agatgttgaa gaatctattt
    16201 cttgtggtgt tgatgcagta gctatatcaa tatcagtatc tgacattcat atagaaaata
    16261 aattgagaac ttctagaggc tgggttttag aaaatatggc taaaacagtt gaatttgcaa
    16321 agaaaaatgg attatatgtt tcagtaaatg gagaagatgc ttcaagagca gatatagact
    16381 tcttaactga atttataaat gttggaaaac aagcaggggc agatagattt agatactgtg
    16441 atacagtagg agttatgaat cctttttcta taaagaatgc aatagaaact ctttatgaaa
    16501 gaactaattt tgatatagaa atgcatacac ataatgactt tgggatggca actgcaaatg
    16561 cacttgcagg aatagcagca ggagcaaatt atgttggtgt tacagtaaat ggattaggtg
    16621 aaagagcagg aaatgcagca ttagaagaag ttttaatggc acttaagtgt gtttataaat
    16681 gtgatttaaa taatatagat actagaaaat ttagaggaat atgtgagtat gtagcacagg
    16741 catcaggaag aatacttcct acatggaaac cagtagttgg ggataatatg tttatacatg
    16801 aatctggtat acatgcagat ggagctttaa aagacccaca taactatgaa ccatttgacc
    16861 caagtgaagt aaatcttgaa agaaaaatag taataggtaa acattcggga agagctgcag
    16921 ttgtaaataa gttgagtgaa tatgaaatgt atatttctcc agaaaacgct accaagctat
    16981 taaatgctat aagagctaca tctataagat taaaaagaag tttaatggat aaagaaattc
    17041 ttcaattata ttgtgatata ctagcacatg agaaaggcac aacagaagaa gaagcagtta
    17101 gaggttcata tatttaagat ataattgttt aggaggaaaa tatgggagat aatatagttt
    17161 ataaaataat taaaaaacat atagtagatg gagaagctgt tgctggaagt tcaattggta
    17221 taaaaataga ccaaacttta acacaagatt ctactggaac aatgacatat cttcaactag
    17281 aagctatggg aatagataaa gtaaagacta aaagaagtgt ggcatttgta gaccataata
    17341 tgttacaaca aggatttgaa aatgcagacg accataagta tatacaaaca gtggcagata
    17401 aatatggagt ttatttctct aagccaggaa atggtatttg tcatcaagta tttttagaaa
    17461 gattttcaac accaggagat acacttttag gttctgatag ccacacacct actgctggag
    17521 gtgtgggcat gatggctatt ggagctggtg gattagatgt tgctttagcc atggcaggag
    17581 gagcatacta tataaaagca ccaaaagtct gtaaggtgaa tctagttgga aaattaaata
    17641 atatggtatc atcaaaagat ataatattag aagtgttaag aaaacaaact gtaaaaggtg
    17701 gagtaggtaa agtttatgaa tatggtggag aaggtgtcaa aagcctatct gttccacaaa
    17761 gagctacaat aacaaatatg ggggctgaac ttggagcaac tacttcaatc ttcccaagtg
    17821 atgaaaaaac actagaattt tttaagagtc aaggaagaga agacgcatgg gtagagctaa
    17881 aaccagatgc agatgcagtt tatgatgaag agattactat aaacttggat gaattaaaac
    17941 cattagctgc aaaacctcat agcccagaca atgtagatga agttgaaaat ataggcaaga
    18001 ttaaaataga ccaagtggca ataggaagtt gtacaaattc ttcttatgaa gacttaatga
    18061 aagtagcaca aatcctgaaa ggaaataaag tacataagga tgtgagtttg gtaatagcac
    18121 caggttcaag acaagttatg gagatgattg ctagaaatgg ggctttggca gatataataa
    18181 gtgctggagc tagaatacta gaaaattctt gtggtccatg tattggtatg ggtcaatctc
    18241 caggtactga ctctgtgtct ttaagaactt tcaatagaaa tttctatggt agaagtggga
    18301 ctttgtcagc acaagtatat ttagtaagtc cagaagtggc agcagtaagt gcaatcaagg
    18361 gagtgcttac agacccaaga gaatttgata ttaaatttac aaatttagat gtaaatgaat
    18421 ttttgataga tgatagcatg ataattaaac ctgctgatgt aggaagtgat gtagaagtag
    18481 ttagaggacc taatataaaa cctttccctc ttaatacaga gctaagtcag tctataggtg
    18541 gaaaagttat attaaagaca gaagataata taactactga ccatataatg ccatcaaatg
    18601 ctaagttact tccttttaga agtaatatac cgtatcttgc aaactattgt ttcaatactg
    18661 tagatacaga atttcctcag agagcaaaag acaataatgg tggatttata gttggtggag
    18721 ataattatgg tcaaggttca agtagagaac atgcagcttt agcaccatta tatctaggtg
    18781 ttaaaggggt aatagttaag agctttgcaa gaatccacaa ggctaacttg ataaatagtg
    18841 gtataattcc aatggagttt tgtgatgaga aagattatga aaatatatct cttttagata
    18901 atctggagat accaaatatt ttagacaatc taggtagtgg aattttagaa gttaagaata
    18961 caactaaagg aacttctttt aaggtcaaag tagaattgtc agcaaaagaa gttgatgtat
    19021 taaaagctgg tggaaaatta aactacacta aaaatcaagc taattaatat gaaaagaggg
    19081 aatattgaat gtataaagtg acacttatac caggagatgg aataggacca gaagttgcga
    19141 aagctatgaa aaaggtagta gaagctactg gagtagaaat agaatgggaa gaagttaatg
    19201 caggagaggc agttattgaa gagtatggta ctccacttcc tgaatatatt atagatagta
    19261 taaaaaagaa caaaatagct ataaaaggcc caattactac tcctgtaggt aaaggattta
    19321 ggagtgtaaa tgtaacttta agacaagcat tagatttgta tgtcaattta agacctatta
    19381 aaagttttaa ggggataaaa tcaagatatg aagatgttga tttagtggtt gtaagagaaa
    19441 atacagaaga tttatatgct ggaatagaac ataaaatagg tgattatgca gctgaaagta
    19501 taaagataat aacaagaagt gcaagtgaaa gaatcgttga ttttgcatgt aactatgtta
    19561 aagataataa gagaaaaaaa gttacagcta tacataaggc aaatataatg aaaatgtctg
    19621 atggattgtt tttagatgtg tttagagaag ttgcatcaaa acatggtgta gaatatgatg
    19681 atttgattgt agatgcagca gctatgaact tagttttaaa tccagaaaat tatgatgtaa
    19741 tggtaatgcc aaatctttat ggagatatac tatcagattt aggtgctggg cttgttggag
    19801 gtttaggtat aattccaagt gcaaatattg gtaaagattg tgcgatattt gaagctgttc
    19861 atggaagtgc tccacaaata gcaggtcaaa ataaggctaa tccaacagca cttattcaat
    19921 catcagtaat gatgcttaga tacttaggtg aatatgaaaa tgcacaaaaa atagaaacag
    19981 ctttagaaaa agtatttctt gaaggaagta aattgactgt agatttaggt ggctcagctt
    20041 ctactacaga gtttgcggat gaggtgtgta agtatattgt atagatttta tttagggaaa
    20101 aagtaaaata tagattgaag aaaagaggct ttctcaaaat agagataagc cttttttatt
    20161 ggaatgataa aatatatttg attttataca aaagagagtt cctcataaac gaaaaagtta
    20221 attttgggat atccatttta attttaaaat taattgatta atatgcaaag aaagattaaa
    20281 taaatttatt atttttaatt gaactttcaa ccaaaatatg gtaaaattta aaaaagttga
    20341 actttcaact aaaaatgaat atattgatta tgtgaaattc tataaaacag aaactatttg
    20401 actttagcca tagtagtttc agtggaggtg tgtttgatta agactttaga cagtaatata
    20461 ttaagagaag taggtacttt atctagagca gtaaattcaa taaatgatat taagtacaag
    20521 gaattaaagt tacaaaaagg acaatttaca tttttgacaa gaatctgtga aaatcctggt
    20581 ataaatcttg tggaattatc aaatatgtta aaggtagaca aggctacaac aaccaaggct
    20641 atacaaaaat taataaaggc aggatatgta gataaaaagc aggatgagtt tgataaaaga
    20701 ggatataatt taactccaac tgataaatct ttggaagttt atgagttgat aattgaagaa
    20761 gagaatagaa gtatagagat atgttttgat aattttacag atgaagaaaa acaagtggta
    20821 actaagttat tagaaaaaat gagcaaaaac gtagaaaatg aatggtttaa agtaaagaga
    20881 tagtaaataa atacattaac ttaaggagat atttttatga ttagaaaagc gaatatgaat
    20941 gatttagaaa gcattatgaa aattataaaa tctacagtgg aagaaatgaa gacttataat
    21001 aatacacaat gggatgaaaa ctatccatta gaaaaagact ttgtttcaga tattaagaaa
    21061 caagatttat atatttatga agtggatgga gaagtagcag ggtttatatg tcttaattat
    21121 gaagagccag aagaatattt aggcttaaat tggtcatcta ataaaaaagc aatggtaata
    21181 catagaatgg ctgtaaatcc aaactttaga aagacaggga tagcatctaa gttagttgat
    21241 tttgctgaaa aattagctgt agaaaacaat gtatcatact taaagagcga tacatattca
    21301 ataaactcaa aaatgaattt attacttaca aagtgtggtt ttataaaaat cggagaaatg
    21361 agttttttag gaaaggagaa atctttctac tgttatgata aaatattata aagagcattt
    21421 acaatacaag gggtaaataa tagattttca gcattagtaa gggcataata taacttagta
    21481 tatgctatta tgaaagggat gatttatatg attggatttc taaagaaaag aagaagtatt
    21541 agaaaataca aggatgttga agtagaaaaa gaaaaattag ataaaatatt aaaagctgct
    21601 cttttagctc catcatcaaa ggggcttaga acatgggaat ttatagtggt agatgataaa
    21661 gaaaagctaa ttaatttatc tcaatgtaga actaaaggtg gtggattttt cttaaaaaat
    21721 gcacctttag ctattgtaat tattgcagat aaagaaaaaa atgatgtttg gatagaggat
    21781 gcaagtatag ctgcttcata catacaactt caagctcatg aactaggttt aggttcttgt
    21841 tggatacaag taagaaatag aatgcatgat gataatatag aagctgataa gtacattaga
    21901 gaagaattaa aagtacctag caagtacagt gtagaatgta taatttctat aggatatcct
    21961 gatgaagaaa agaaagcata cagtgactct gatttagact ataaaaaggt tcattttaac
    22021 aacttttagt atataatatg ttgtattaag acattatatt tttttctatt gttaatatat
    22081 acttaaaatt gtaaaaatat atctgaattt tactaactta tctaggggtt atgtacaagg
    22141 attttaaaga taaatataga aattaatgtt tataatcgat acataacttg agtaacaaaa
    22201 tttaaggagg ttaaagtatg ggtatattta aaacaaaaat ggatgaggac tggaaagtaa
    22261 actacattaa agagtttaat gaaatgagag attcttatga gagtaaactt caaaaaaaac
    22321 agtttgaggt agatagtttg aaatcagaat tggatagact aagaagctat aaaaatagcc
    22381 ttaagccaaa agaaaaacaa attactgatg atgatataaa taatataaag agtttaagaa
    22441 gagatggctt aagctataaa gaaatttcaa atcaaacaag ttggagcaaa gcaactgtaa
    22501 gtagggtatt aaatggactt tacgattagc atatacatgg ggtgatttaa attgggatga
    22561 agtatagtta caaaaaatgc ataatagatt ctattttatt gatgtttata gttcaaatat
    22621 taaggatgat tttgaattat gtacttctaa gtcaatttga atttactctt gaaaatttta
    22681 atattataaa cttaatttct tttacattag ttggtttatc gttaatttta tttttaaaag
    22741 ataattcttt gtataacaag gttagaaata gaaaaatcac agaagctttt gaagaaaata
    22801 aaaacaatat acttattgaa aagtgtaagc tgatactttt tgttgtggtt ttatctttag
    22861 caataattgt aacttattgt actaagggat atgtactttt taatgtaact atgatgactt
    22921 tgtctgtatt gatagttcca atatttgaag agttattttt tagagaatat atatggaact
    22981 atctaagtaa ttttataaag tcaaagagta aaattatctg tataacatct atactatctg
    23041 gaatttataa tataggatac atagatgtta taagaaatta tgtaatattg tataacaatt
    23101 cgagctacac ctttgaagtt attatttcaa aaattatgat aggtactgtt tttggtattg
    23161 tacttggatt agttaagtat aggtttagag atgtagggtt ttgtatatta ttgaggagct
    23221 tatttgctat atttattagg tagatagtat aatcggttta taaggttgtt ttaaatttaa
    23281 ttttaaatca accttatttt atttgtgttt tataaagcac ttatatatta ataactaata
    23341 aatttaataa aaattatttg aatattttta aaatatataa atatgtattg acatataaat
    23401 attatgaatt acaatttata taaactaata aaaattaaat aatattaatc aacttattga
    23461 atggaggaat aaaaatgaaa tttgtgactt tttgtagtag caatgaagaa aaaataggtg
    23521 tatttaattc agaaacaaat agtatatatg aaattaatag tttaggatta agtaaattat
    23581 atactgatat gaataatttt attgaaaacg tatctacagg agatttagaa aaaataaaaa
    23641 acaattcatt tgaaaacgca aagtgttata agttagaaga agttaaatta tgttccccaa
    23701 ttgtaagacc taaaaaagat attatatgtt taggtctaaa ctataaagac catgtcaatg
    23761 aaatcccaga tggagttata aaaaacgtag ttatgccaga ttatccaatt tatttttcta
    23821 agagagcaga caaaataatt ggagtggatg ataagataag cttacatgga gatttggtag
    23881 agaagttgga ctatgaatca gaacttgcag taatcatagg taaagaaggt ataaatatat
    23941 caaaagaaga tgcttatgaa tatatatttg gatatacaat agtaaatgat ataagtgaaa
    24001 gagcacttca agataaacat gttcaatggt ttagaggaaa aagcttagac acacatacat
    24061 ctatgggacc ttatatagta cataaagaag aatttgaaca tcctttaaaa ttagatataa
    24121 gtagtgtagt aaatggagaa gtaagacaaa attctaatac agagtacttt atatttgata
    24181 tacctactat aataaatgat ttatcaagag gaatgactct aaagccagga gatataattt
    24241 caactggaac tccagcaggg gttgctatgg ggatgaatcc tcaagtatat ttaaagcatg
    24301 gcgatatagt tgaatgtaaa gtcgaaggaa taggagtttt aaaaaatata gttgattaat
    24361 ggataaatat gccatataat tttattagta cgaataattt aattaatata ggattaatca
    24421 aacttatgat taatttatta tagagaggga tgagtatatg gcaagagaac tagaattaaa
    24481 gtatggctgt aatccaaatc aaaaaccatc aaagatttat atgaagaatg gagaacttcc
    24541 tatagaagta ttaaatggaa aacctggata tataaatttt ttagatgcat ttaatagttg
    24601 gcaacttgtg aaggaattaa aagaagctac aggtctccca gcagcaactt catttaaaca
    24661 tgtaagtcca gcaggagcag cagtaggggt acctttatca gatactttaa agcaaatata
    24721 ttttgttgat gatttagagc tttctccatt agcttgtgct tatgcaatgg caagaggagc
    24781 agatagaatg tcttcttatg gcgattttat agcactttca gatgtatgtg ataaggagac
    24841 tgcaactatt atagcaagag aggtttctga tggtataata gctccaggat atacagatga
    24901 agcccttgaa atattaaaag gaaagcgtaa aggcaactat aatattgtaa aaatagatga
    24961 aaattatact cctgaaccta ttgaaacaaa ggatgtttat ggaattactt ttgaacaagg
    25021 tagaaatgaa atattaataa atgaagacct attaaaagat attccaactg ataataaaat
    25081 ttttacagat agtgcaaaac gtgatttaat tatagctctt attacattaa aatatacaca
    25141 atcaaattct gtttgttatg ctaaagatgg acaagtaata ggggtaggtg caggtcaaca
    25201 atcacgtatt cattgtacta gacttgcagg taacaaagct gatacttggt atcttcgtca
    25261 acatcctaaa gtattaaact taaaatttaa aaaggatata ggtcgtccag atagagataa
    25321 cactattgat gtatatcttt ctgatgatta tatggatgtg cttgctgatg gcatatggca
    25381 aaactttttt gaagaaaaac cagagcctct aactggagaa ggaaaaagag catggcttaa
    25441 aactttaaca ggagtagcac ttggttcaga tgcatttttc ccatttggag ataatataga
    25501 acgtgcaaaa agaagtgggg taagttttat agcacaacca ggtggttcta ttcgtgatga
    25561 taatgttata ttaacttgta ataagtataa catagtcatg gcatttacta aaaatagatt
    25621 attccatcat taaaatactg aaagtataaa gataatatag attaggtaaa aatctacaac
    25681 aagttttgtt gtagattttt ttatttgctg tataatttta aatagaactt tatttttaga
    25741 tattcaattt ggaggttgat atggctttaa atataagaaa ctatagccta ttatgtaatc
    25801 aaggaacagc taaatttaat gaagatgtag tcggtataaa tccatttggg gcatgggttt
    25861 tagatggtgc tacaggactt aatggaaaaa atttagtgtc aactgaaagt gacgcaaggt
    25921 ggtatgttca gtggtggaat aggtatttat ataaaaatat aaataaagaa gaatcattaa
    25981 agagtattat taatactgga ataatagaag taaaaaaaga gtatgaacta agattaaatg
    26041 ggtttaaggt tgaaaaatta gatttaccat ctagttctat agttgttgta aaatttcatg
    26101 aaaataaagt agagtatttt ttattaggag attgtgcttt gtttattaaa aatggagatt
    26161 ccaaagttat aaaagatagg agtatttgta aatttgataa tactgtattt gatgaaatga
    26221 gtaaactttc taacttggaa gagatggctt ttgatgagat tagaactagt gttatggata
    26281 caatagtaag caatagattg aagaaaaata caaaagaggg ctattggata ttggattttg
    26341 atgaggaagc tgtggaaaat tctatatatg gatacattga aataaaaaaa gattttcaat
    26401 tgatgctaac gagtgatggt tttacaagtg catgtgatag atataatcta ataaaagaag
    26461 aagaattgat acgtatagca gaaaaatttg gtataggata tatacataat aaagtaaggg
    26521 attttgaaga taatgactat aaagcggtta aagtgccaag atttaaagta aaagatgatt
    26581 catcttgttt atatttagat atatataatg attagactgt ataaaactat ttaattttag
    26641 aaaggaggca agtgaaaagt gaaaattctt catataataa cacaaaaacc aaatagtaca
    26701 ggtagtggta tatatttgtc tggtatgata aaagggttcg aaaaaatcgg tcataagcaa
    26761 gctgtaattg caggtataga tgtaaatgat gatgtaaatt gttttccaag tgaagtaagt
    26821 ttttatccag taaagtataa ttgtggggag ttaaattttc ctgttgtagg tatgagtgat
    26881 tctatgccat atgaaagtac aagatataaa gatttaaata tagacatgat aaatagattg
    26941 aaatatcaat ttaaagtaaa tatagataag gctatgaatg attttaaacc agaacttata
    27001 atatgtcatc atttgtacct cttaactgca tttgttaggg aaatggtaaa agatataaag
    27061 gttatgtcta tttgtcatgg aacttgttta agacagttaa ataccattga tttagagaaa
    27121 gaatacataa tagcaaatat aaggaaatta gatttaatat ttgctcttca tgaaaatcag
    27181 aaatatgata ttataaagac ttttggagta agtgaaagta aagtagttgt aattggtagt
    27241 ggttataatg atgatatatt ttataataaa aattataaaa taaaggatga taaaataaaa
    27301 atagtatttg caggtaagat atgtaaatca aagggactga ttccatttat aaaagctata
    27361 tctaaattaa aatatagtaa agatttaata gaagtcaatt ttgcaggtac tggaagcgat
    27421 atcgaatcat ataatgagat agttaaactg gcaagtaagt ctccatttaa aatgaatttc
    27481 ctaggaaagt tagaacagag agatttagct gagctattca acaggtcaca aatatttgtg
    27541 ttaccatcat tttatgaggg attaccagtt gtagttttag aagctttatc ttgtggcaca
    27601 gatgtaatca ctactgatat tcttggtgtt aaagagtgga ttggtagtga gattaataat
    27661 tctggaaaga tagaatatat ttctctacct tttatggaga aagaaggtat tccaaaagat
    27721 gaagagttat atgattttga aaataatttg tataatgcaa tagattctaa gatacaatct
    27781 ttattgaata actcaaataa gaaaacatct gtagatatgt caaaaaaaac gtgggatggc
    27841 ttagcatata gaataaatga agttatttta atggatgaat tgtgtttagt ctaaaattat
    27901 ttaaattata aaaaagtgta actattttta cactattttt aaatgatttt atattatact
    27961 aatactaaat atatttgttt tagggaggta atttatgagg attagtaaaa aggtattggc
    28021 gttaggtatt tcagcattac tgttaagtgt tagttttcca acatcaataa acgcactaga
    28081 taagattgaa aatattcaag gagtagataa atatgaaaca gctgggctta tttcagataa
    28141 gcaagatttt acaacagcag ttcttatcaa tgcagattct acaatggtag atggaattgc
    28201 tgcaagtggt cttgcaggag taaataatgc agctatttta ttaactaata aggatgatat
    28261 accagaagca acgcttcaaa gactgaatag agttactaag atatatgtaa taggtggaga
    28321 aaattctata agtaaagatg tagaaaaaat gttacttatg agaagaatgc aagttataag
    28381 aattgatggt gtagatagag tagatacaag ttataaaatt gcaggcgaaa tagaaaaaat
    28441 taaaaacagt gataagatgt ttttagtaaa tggatttaag gatgaagctg atgcagtaag
    28501 tgttgcatct gttgcttata gagatggagc tcctataata ttgacaaaag atataccttc
    28561 agcagaagaa gacacagact tagacccatg gtttggagtt tctcctgttc cagtatatgc
    28621 tattggagga gagtctacat taagtgatta catagtgagc agatatagag caactagaat
    28681 tggcggtgtt gatagatatc aaactaataa aaatgttatt gaaaagttct ataatggagc
    28741 aaaagagttc tatataacaa gtggagacga tttagtttat gctttagttg catcaccact
    28801 tgcaaaaaat gctcctgttg ttttagtttc aaataaaagt gataagagta tattaagtgg
    28861 agctagtaaa gtaacagcaa taggtataag tgataagagt attatagagc aatgtttgga
    28921 tgctgtaaag aagtaatgga gtgttattag taaaatgaat atacacattg aaaattagta
    28981 gattgttcat tttataatgg tataaaatat atgggaagag gctatcaaat ggagataagc
    29041 ctctttttca tttatttttt tgcgtccctt attggtaata aaagcttccc ctgctaaaat
    29101 tcttccccaa aatacggttt cttcttggtt ggtttttttt acagccattt cagatatttt
    29161 tatcaattca cagtttgctt caaaaaatac ggttttcaac catgagtgaa attctgtcag
    29221 agtatcttgt gtaacatcat gatgacaaac ttccgtagat attaccatat taaatatttt
    29281 caattttggg ttcattccac ctgctgtccc tgaattgaga acgatattta cttcaaaaag
    29341 gtcaatactt tagtttccaa aaaacgggga tttattgctt tcgtttactt tttcgatttt
    29401 tccagacatt gtataaaata tctttaagaa ttaacattgc ttccagttca ttatattggt
    29461 attcctgttt taattcgtcc aacatcatgt taaccttata agcataatta gaaatattaa
    29521 catctgtctg atatttaaga agaatagggt atttttttcc ccaggcattt gtccaattga
    29581 ttttttcttc ggtttcctca cttgttttat taatcgcttc ctgaatttct tccatgtcaa
    29641 tatcaaaatc aatcaattca tctaatgaca cattgtaaag tattgctaat ttttttgact
    29701 gacgaatgtc tgggactgtt tcatccgttt cccattttga aacagtctgc ctgcttaccc
    29761 ccagtttttc agctacatct tcctgtgaaa gcccatgttt cttccttgcc tgaaataaac
    29821 tatttcctaa attcattgaa attcctcctt atctgtttat gggattatta tattatttga
    29881 taagaacaaa ctctaccaac taaaattatc atatttgcta tttttattaa cataattcaa
    29941 agacgtattt attctgcaaa ttaaaatctg ctaacctctg cgaatatcaa tcattaacca
    30001 cttttatcca ttccctgttt ttgtttgtac gtaaatatct cttaattctg gtgtaaactc
    30061 ctgtaaaatc gcttcgacaa cctctttctc tttctttcaa acaacaacta aaacgtaaaa
    30121 taattttctt tcggatatac tgtgcataaa ttttttctag gttttttaaa tttgatattc
    30181 cagccaaatt cccaactgca agaactaaat atctattttg agacactatc tccttttctt
    30241 atattatatt attttttata tggaataaat ttcataagta ttatcttcct ttaatttttc
    30301 taaccaaacc atttctaaaa tatctagttc ttctaaatag tctttctctg ttttgttatc
    30361 atcatgtttt ataagctcta aaacttcaaa tgtaaatgct ttttcaccat attttttcca
    30421 ttcattattt aattctttta tcatacatga gccagcacca agctgaaatt tgagagagtt
    30481 aaatttgctt tttatatcat tactttttcc aaggtaaatc tttttagtaa tatcattttt
    30541 tattatgaat acacctgtgt caaatttcat ttctttgtat aattgtttta attcacgttt
    30601 tctatccatg attttagata cctctcttta taattgatat gtaatatgta agtgtaaaaa
    30661 tatattacat atcaattata aagagattaa ttttatatgt aaatagtttt tataaattta
    30721 attatgaatt agtcatcaat aaacaagaaa tttagctgta gaaatccatt ataaaggcta
    30781 ttataaattt taatatgcta aaaatataaa aagaatagtt gacagtgtag aaaatatgga
    30841 ataaactaaa agtgtaatag taatattaaa ttatatatta cattgaaagg tgtgaatgat
    30901 tattatgaat aaaaaaatag aattaatagg gaattttgca agtgattgga ttaggtatag
    30961 tgattatgaa tataaaatta ctgaagaaga tgaattatat atagttccaa cagaagatgc
    31021 tgtgtttacc atgtataacc catttgatgt agcagatgat ataatagtag atataattcg
    31081 cataggacaa gaggcattac aagatatatc aaaagagaca aaagaaatga aactaaagaa
    31141 agaaatactt gaatttgtaa aaaagtatgg attattgggt ttaatatatt caagtgtata
    31201 taatagagat atagttggag aagaaagagt actgatgatt gaaaagaatt atattacaaa
    31261 agagaatata ttgagtacag atgaatatgt aaacatgttt ataccatttg caagtgatga
    31321 agatgtgtat tttaaaaagt atagaagggg tatagatgta tcaaagagag aagaatctcc
    31381 aaagtttttt ggaaagagac cattgatttt agatttagta ttttcaaagt tctacactga
    31441 acaactagat tggattgtaa gttttgctaa agatatgtgt aagcatttta atcaaatttg
    31501 tgtatataaa aatacatcta atctattaac tgaaagtgtt actattatgt ctggagggtt
    31561 taatcctcaa aagataggat tttctataag ccaattagat aaaccaatta ttgcatggga
    31621 gtttgattct ttgaaaacag ctattgagac tatctatgcc tttgcaatta caagtgaacc
    31681 ttcttcttta aataaatgca agtactgtgg taaaatttat attcctacaa attctaaatc
    31741 tcaatactgt tcaccttctt gtagaaattg ctcaaatgta aagaaaagta gaagtagagc
    31801 caaaaaagat aaataaaatt aataaatata tcattgttta gattttagta aataactact
    31861 gaattaaaag ttgttatata aaattatata tctaaatgat ggtatttttt ttgttgagaa
    31921 aattgaaaag tttaattgag atagtaattt tgagttgaca aaaaccactt ttaacactac
    31981 tattataagt ggttggtaaa ataatatata ctaattcaaa tatagcataa aaaacaaaaa
    32041 aagtcaatgg aaaaaataaa aaaggagaat ttaaaaatga tatcacctat tattttgagt
    32101 tctataaatc agaatttaaa ggaaatagaa agaaatgaac tgcttgaaac taatatagaa
    32161 tctggagatt atggtctagc tctttctgaa tctgatgtaa aagatataat aaattcgaga
    32221 gataatactt taaaggggta tggaagaata gaattagata taaaagttac aaaacagtta
    32281 atagaaaata tatatacatc acaatataca aatgtggaca attatttaga ggctattaat
    32341 gatatgcaag aaatttttta ttatttaaaa aatgaaactg atgacaagat atgtgatgat
    32401 gagattatag aaatactggg tgatttttat gaaaaatttt caggcaatat ggacaatgta
    32461 agaggagaag cagacgaatt tgcaaagaaa tttaaatttg gagaagttta atatatgata
    32521 ggagagattt tgtatgttaa ataatttaag taatattaat ataaacgaaa ataatttaat
    32581 aaagaaccaa tattccatat ctctacttaa ggaatgtcta aattgtaaag tgatagatga
    32641 aagagaagta tataatatac aacaagaaat atctctaata cttatggatt tgattaaaaa
    32701 atatacaaat ggtcaaagca catcagtaaa aacagaagtt gccgaaaaac tgttgatttc
    32761 aatatggtat gctattgatg catatataaa taagcttgga gatatagaaa aaagagttgt
    32821 ggagttgact gctaagaatg ttaaaaaagt gtaccttgga ggaattgaaa tattagagga
    32881 agagttagtt aggctaaaag atttttataa actaatgatg agtagaaaat tggatactaa
    32941 ttcaatagca tataatgata ccttgatgga gttatcaagt ttctttaaaa gttatattgt
    33001 aaaatttgaa gctcaggacg ttccagtaag tatagattat ccattggcac tagatgatat
    33061 ggatgttaag ggtatttatt atgtgaagaa ttatattgag agtatagata tagaaaatag
    33121 attttgtaac ctatttaaga aaaaagatag agaaaaatta ttttatgact atggggtgac
    33181 ttataaaata gattgtgatg ttatacttgt aaatttattt gaacttatta tgaataattg
    33241 tattttttct actattttag gaaatgaagt gactaattta gaaatttcaa aatatgagta
    33301 tgaattttta gaaaaacaat ttaaaaatat gtacaataat attactgaag ataaagttat
    33361 agactctgaa gaaagtaata taattgaatt gattgaagta gatgatagtt ttaacactga
    33421 agtagatagt aatttggatt ataatgattt tgaagaaatt aacagagaaa ttagaataaa
    33481 taaaaaaata actttactac ttatggaagc aattgaagta ttaataaaaa gattaagcat
    33541 agaagatgaa gatgtaataa gatatattaa aaaatatgaa aagatattta ttgaatctgt
    33601 gctaagctca ataaaaagta acacttttaa aagtatggta actgtgagta aaaataaaaa
    33661 tgaacactta gaagattata ttgttgatga tgaaagtaaa ttggatgatg aatcgtttag
    33721 agagatattc aatgagatat tagatagtac atctataatt gaaaaaataa gaataataaa
    33781 ggaaaatatc aatgctaaaa aagactttat cgatattctt gaatctgaat gtttatttgg
    33841 agaagagtat ttaatgttgt ttgcatcatt aagtgaatta gaattggcaa tattgggtag
    33901 tgtagtattt tatgaagata ttagaatgag agaaattaat atattagaat ttatgttaaa
    33961 tgagaaaact gaaactactt tatggaagat agagtacatt aaatttatga agaggcaaag
    34021 tgaagataag atatactcca tagaagagca tatgaataaa attaattaac aaaaaattgt
    34081 gaataaatag aatgttagta tataatataa tctgtaaagc atatcaaaaa tacatatatt
    34141 tggaggaaaa ttatgaaaga gtatatcata aataatgttg aagaaataag agaagaatta
    34201 attgatttat ctaagaaaat atgggaaaat ccagaattag cctttgaaga aaagtatgca
    34261 agtagcattc aaaaagaata cctaaagtca aaaggattta aaattgaaga agtagaaaat
    34321 ttacctactg gatttatagc aagttttgga gagggtaaac ctgtgattgg catacttgga
    34381 gaatatgatg ctttaccaga actatcacaa tgtgtaagtg cagaaagaaa gccattggta
    34441 gaaggaaaag ctggacatgg atgtgggcat aacctgttgg gtgtagcagg tgtaggagca
    34501 gttgtttcta taaaaaaatt aatagaagaa aataaattta atggaacaat aaaatatttt
    34561 ggttgtcctg ctgaagaaga aggtggagga aagacagtta tgtgtataaa tggctgtttt
    34621 gatgatgtag attgtgcatt tacatggcat ccttttgata taaatgcacc ttggagagga
    34681 ggaagtctgg caaacttatc tgtaaaattt aaatttaaag ggataacagc ccatgcagct
    34741 caagctcctc ataatggtag aagcgcactt gatgctgttg aaattatgaa tgttggagct
    34801 aattatttga gagaacatgt tattgactct ataagaatgc actatgttat aactaatggt
    34861 ggtggaagac ctaatgtagt tcctggattt gctgaaagtt ggtactttat tagaggtaaa
    34921 aaagcaaaag atgcagaaca cgttcttgat agattaataa aagtagctca aggagcagca
    34981 atgatgacag aaactgaaat ggagtataag gttacagatg gaatatatga ctatatacca
    35041 aaccaatgtt tgactgattt agtttatgac aatatggttt ttgttggttg ccctaaaaat
    35101 actcctgaag aagaagaatt tgcaaaaaag ttgtgtgata ctcttactag agaagaaaga
    35161 ttaggtgtag caacatcatt acaaaatgat aaatctattg tagaaagcta tatacacaag
    35221 gaaatagttg acggtgacaa agataaagga ctagctggtt ctactgatgt tggagatgta
    35281 agttatgtaa taccagtggc tcaatttgca atggcagctt ggcctgttgg aattgcaagt
    35341 catacatggc agtcatgttc atcagcaggt tcaaatatag gattttctgc tatgataaat
    35401 tcagctaaag tactggcttg tagtgcttat gatgtattta tggatactaa aattattgat
    35461 gaagcaaaaa ttgaatttga taaatcatta gatggacaaa aatttaaacc attggtataa
    35521 ttttggtaat aaaatatttc aggggggaat agctatgaga gaaaaagttg aaaaagtgct
    35581 tgaggaaaag ataaaaccag tattacaaag agatggtgga gatgtagagc ttatagatgt
    35641 aaatgaaaat ggtgtggttt tagttagact acaaggggca tgtagtgggt gtccaggagc
    35701 gactatgaca atcaaagcta ttattgaaaa tgttttggtg agtgaagttc caggagtaac
    35761 tcaagtatta ggtgtttaat agttagcgtt tattaaatgt atgttataca taagtattta
    35821 ataaagaagt aaaaaaaata gtgaaacaat atatatgaaa aagtatgaga aagataataa
    35881 aacatttata gaaataatgg aatatttcat atatacatat gaagaaatag taaaacaata
    35941 tatatatgaa aaagtgtgag aaaataataa aatactatag aaacaattaa atattctata
    36001 taggtattaa ggaacatgaa agaaataatg gagtattata aataaatatg taaaagtgtg
    36061 aaagaaggat gtaggtaaat ttgtcttata caaatttacc tacatccttc tttcacactt
    36121 tttattttac tatccagcca taccaataaa catacctata aaatatggaa ctaaccatat
    36181 agtccataca actatactaa acttatgaaa gaattttttc ttttcctcat catctttgta
    36241 taggacaaaa gtagcccaac ttgcatgaaa aagcataagc acaattgcaa gaagacctgt
    36301 aatactatga aggttttgtg ataaagcaga ttttacttca aaagtatggc tgttggctat
    36361 gttactcatt gtaaatgttc ctaaagtatc aaatataaaa ccaagccaaa atataattac
    36421 atgtttcttt tttaaaattt ttgcctttct ttctccaaat acacctatag tgtagaaaat
    36481 taaagctgat gttataaata ctattgcaag tattaattta taattcataa ttatctctcc
    36541 tttacttttg ccaatatatt tctaagattt tttactaagt cactcaattc gttttcatca
    36601 caatttttaa aaatatcatc aaaactttct tgcattttaa ttttaaaatt tgtggcaaat
    36661 tcaaatcctg ttgttgtaaa cttaacgtat gtatttcttt tatcattaga tttcttgaat
    36721 ttttctatat atccaatctg ttctaatctg ctgattatgc ctgaaaccgt acctttagct
    36781 aaagacattt catcacatag ttgtgatatt gtaagttctt gattatgagc tatcagtttt
    36841 ataactataa tctgttggtg tgttaatcca ttttctttaa aattttcttc tactgtgtac
    36901 atagttttag aataaagttc ttttaagagc atggctattc taaaacagtc ataattactt
    36961 ttcaataaaa tcacctctta aatggtttgc atacaaacta atataatata cttttcttat
    37021 atagtcaacc taaaatttta taattttata gaaaataatg aagaatagaa tataaaaatt
    37081 ttattttagg tataaataaa ataatttgat gaaattttaa caatttttaa aaagtttgtt
    37141 tacacagtta ataaatgatg ctaaaattaa ctcatagata aatatagaaa atttaatttt
    37201 gtttaatgat aatggaacca cgaaggtttt aacgttactt tacgtttgct tttatgtggt
    37261 tttttttatt gcaacaaagg ggggttgggg tttgttaaag gatatactga aaaagttgtt
    37321 gcagtttatt ttagtaatgt ttttattatc ttttattgtt ttttacatgg caagacttgc
    37381 tccaggagac ccattaatct cttactatgg ggatggagta gaaagaatga gtacacaaga
    37441 aaaagaaaat gctatgaaaa aacttggttt ggatgaacca atatacagtc aatatataaa
    37501 atggatttca aatgcatcaa aaggggaatt tggaatttca tttaaatata aacaaaatgt
    37561 tacttctgtt ataaatgatg tctatataaa cactataata ttaggtggtt caggatatat
    37621 acttaccttt gtgctagcct tattgttagg aatattttgt acattacatg aagataagct
    37681 cattgataga atcatatgca aattaggaac aataaccaac tgtattccat cattttgggt
    37741 tgccttagta ctcatactta tatttagtat aaacttaagt atacttccaa gtagtggtgc
    37801 ttattcaatg ggagaagagt ccagtatatt aagtaggata tcacatctaa tcttacctct
    37861 tacagtactt atattaagcc atctatggta ttacacatat atgataagaa ataaattact
    37921 agaggaaata agagaagatt atgtgctttt atgtaaagca aaaggtttaa ataatagaac
    37981 tattgttttt aagcattgcc tgagaaatat aatgccatca tatattagta ttatggccat
    38041 ttcgatacct catatactag gaggaactta tgtagttgaa aaagtttttt cttatcctgg
    38101 gttaggaaca ctttgctttg aaagtgcaaa gtatcatgat tataatatgt tattagtttt
    38161 atgcttaata acaggggctt tagtagtatt tgggaatatg ttagctcaaa ttataaacaa
    38221 taaaatagac cctagaatga aatatgatag aggtgatact aatgaagcca caatatagtg
    38281 attttgaaat tgtaggagaa aattatattt tagtagcaga agatgaacat atagaaacaa
    38341 agaaaacctt atctaaaaaa attaaagaat taccatatat atcaattatt attttatcaa
    38401 tcatagtcat tggaagtgta ttctcatctt ttataatgac acatgaacca acatacatgg
    38461 atttagcaag ttctaattta gctccaaata aaactttttt atttggaaca gactcaatgg
    38521 gtagagatat atattctatg atatggtatg gaggaaaaat atctttattt ataggactat
    38581 tttccactgt aatatcaact gttataggaa ttgtttatgg tagtataagt ggttcagcat
    38641 ctgaacttgt agatgatgca atgatgaggt ttacagaaat catacttagt ataccttcaa
    38701 tattaattat aatatttgta caagctatac ttggaaattc aaatccagta tctatgtcca
    38761 tagtaatagg gataacaagt tggatgaata tatctaagat agtgagaaca gaagttagac
    38821 aaataaaaaa tagcgaatac atactagcag ctaagagcat gggaggagga ttcttctatg
    38881 tattaaagca acatttactt ccaaattttg tggcatcaat aatgttcatg gttgtaacaa
    38941 acataggcgc agctattggt actgaatcga cacttagctt tttaggaatt ggtttaccaa
    39001 tagaaattgt ttcttgggga agtatgttat ctttgtcaga ggaagcatta ctttcaaata
    39061 gatggtggat tatactgatt ccgggtatat ttttggttac cacattggtg tgtataacaa
    39121 atataggtaa ttatataaga aagaataata ataaaaaatc tagtaattta taaatcagca
    39181 tttgagtatt aaataagcaa atactgaggt atttgaaata tctatttaaa taaatggggt
    39241 caaagctttg aaaaatattt tataaaaagc aaaaggggga gcatcatgaa attaaagaag
    39301 ttaaaagttt taagtttagt aatgatactt agtctaatgg caggttgttc tagtggagga
    39361 gacaaagata agaaggcaga tacgcctaaa gatggaaagg tgcttgttta tggaagtaat
    39421 gactatacaa gtataaatcc tgcactatac gaacatggag aaataaattc gttaatattt
    39481 aatggattaa cagctcatga tgaaaataat aaggtggttc cttgtctagc aaaggactgg
    39541 aaatttgatg aggcaacaaa tacatatact tttaatttaa gagatgatgt taagtggcat
    39601 gatggagaga aatttacagc aaatgatgtt aagtttacaa tagaaactat aatgaatcca
    39661 gataatgctt ctgagatagc atcaaattat gaagatataa caaaaattga tgtggttaat
    39721 gataatacta taaaaattac tttaaaagct ccaaatacag caatgcttga ttatttaaca
    39781 gtaggagtat taccaaaaca tgctttggaa ggtaaggata tagctactga tgaatttaat
    39841 caaaaaccaa taggtactgg accatttaaa cttgaaaaat gggacaaagg tcaaagtata
    39901 acacttgtta agaatagtga ttattttgta aaagaaccag gattagataa agtagtcttt
    39961 aagattgttc cagatgataa ggctaaggca atgcaattaa aatcaggaga attagaccta
    40021 gctcaaataa ctcctaaaga tatgtctaac tttgaaaaag acgaaaagaa ttttaaagta
    40081 aatataatga aaacagccga ctatagaggt atattataca attttaattc taaattcttt
    40141 aaagataaaa aagctaaagg attaccaaat gctttaagct atgcaataga tagaaaagca
    40201 atagttgaca gtgtattatt aggacatggt gtaccagcat attcaccttt acaaatggga
    40261 ccatataata atcctgatat agaaaagttt gaatataatc cagaaaaagc taaacaagaa
    40321 attgaaaagc taggttggaa attaggttct gatggaatct atgaaaaaga aggtactaag
    40381 ttagctttcg agataacagc aggtgagagt gaccaagtta gagttgatat ggctaaaata
    40441 tgtgcacaac agttaaaaga aattggtgtt gatgctaaag ctgttgttgt aactgaaaca
    40501 gattgggcta atcaagatgc tcatttaata ggttggggaa gtccatttga cccagatgac
    40561 catacatata aagtatttgg aacagataaa ggtgcaaatt acagtgctta ctctaatcct
    40621 actatagata aaatacttca aaaagcaaga gaaacagaag ataaagatga aaaattaaag
    40681 ttatataaac aattccaagt agaaatgact aaggatatgc cttatacatt tattgcttat
    40741 atagatgcaa tatatgttgg aaaaccaaac ataaaaggat taacacctga tacagtttta
    40801 ggtcatcatg gtgtaggtat attctggaac atagctgact ggacaattga ataatactga
    40861 aattaattag aaaccttagg gataaaaata tatccctaag gtttgaatag cataggggtt
    40921 gatggttttt ggaacattta ttggaggtta ataatctatc tgtaagtttt aaagtagaag
    40981 aaggagaagt tcaggctgta agaaatgtat cttttaatct aaaaaaaggt gagacattgg
    41041 ctatagttgg agaatctggt tgtgggaaat ctgtactgtg taagagtttg atgaggatac
    41101 tcccatacaa tggatatatt aaaaatggag aggttttact taaatcaagt gatttggtta
    41161 agaagtctga aaaagagatg gaagatataa gaggaaagaa tatatcaatg atatttcaag
    41221 accctatgac atctctcaat ccaactatat caataggaaa gcaaattgca gaagctgtaa
    41281 tcattcatca aggtataagt aaaagtgaag caaaaaagag agccatagag cttattgaat
    41341 tggttggaat tgataatcct gagaaaagat ttaaacaatt tccacatcat ttttcaggtg
    41401 gaatgagaca acgtatagta atagctatag cacttgcctg taatccagat gtattgattg
    41461 ctgatgaacc tacaactgct ttagatgtaa ctatacaagc tcaaataatt gatttaataa
    41521 aggatttaca acataaaata ggtttgtcaa taatatttat aactcatgat ttaggagtag
    41581 ttgcaactat agctgataga atagcagtta tgtatgcagg aaagattgta gaaataggaa
    41641 ctgtagagga tatattttat gaccctagac atccatatac ttgggggttg ttgggttcat
    41701 tacctacttt agattcgcag gatgactatt tatataatat acctggaatg cctccaaatt
    41761 tattgaaccc accaaaagga gatgcttttg caataaggaa taaaaatgca cttaagatag
    41821 attatgaaaa agagccacca atgtttaaaa ttaatgatac acatagtgca gcaacttggt
    41881 tattgcaccc agatgcacct gaagtagatg taccagttag agtaaattgt ggaagggtga
    41941 tttctaatga atagagaaaa aatactggaa ataaaaaact taaagcaata ttttcatttg
    42001 gacaaaagta ctactgtaaa agcagttgat gatataagtt ttgatatata taagggtgag
    42061 atatttggat tggtaggaga gtcgggttca ggaaaatcta caactggtaa aactataata
    42121 agactacatg aatctactgg tggagaagta atttacaaag gaaattgcat atcagataaa
    42181 aaaacgtaca aatttataaa aaaagatgta aacaaaagta tgcagattat ttttcaagat
    42241 tctacttcat cattaaatcc acgtatgaca attgcagata taatttcaga gccactaaaa
    42301 attcaaggta tctgtaaaaa taaaacagat agaatgaata aagtatatga gatgctaaag
    42361 ctagtaggac ttgatagaag ttatgcaaat aagtatccat ctgatttttc aggtggacaa
    42421 agacagcgta ttggcatagc acgagctctt tcagtagacc cagaatttat aatagctgat
    42481 gagcctatag cttctttgga tgtgtctata caagcacaaa tagtaaattt atttaaaaaa
    42541 ttgcaacaag aaaagaattt aacttgttta tttatagctc atgatttatc tatggtgaga
    42601 catattagtg accgtatagg agttatgtat aatggaaaat tagtagaatt ggcagattca
    42661 aatgaattgt ataataatcc tattcatcca tatacaaaat cactactttc tgcaattcct
    42721 gttcctgacc ctagatatgc taagtcaaga aatagaatag agtataattc taatggatat
    42781 gattgttcaa atgaaaagtc attaagttgg attgaggttt cagatggaca ttttgtatat
    42841 tcttctaaat cagaaataaa taaatatcaa caaaatttaa aagttgttta gtataaaaat
    42901 acttgaacag gtatttattt gaaatacaaa ctaaaaccct atttttggag aaattttaaa
    42961 actactccaa aatagggttt tttatttcta cttttcaaat ataataaatt caaatataat
    43021 aaaattaaaa acaagtaaag tatgttgtta agaaagtact ataaaattaa aaatagtaat
    43081 gtagaaaaaa tgagcaataa tcttattttt tctacaataa ttttctataa tttaaagtaa
    43141 ggaaaatttg ataaattata accttagtta aagaataaga gtttattaaa aaataaagtg
    43201 tgtatagggg ttttagttaa taaaatacta taatgtaggg gagcttgtaa tgatatataa
    43261 aaaagataaa gtaatgaaag ttttagaatc atcatatagg gaaaatgaaa aagggattac
    43321 agctaaccaa ttatcagaaa agacaggaat tgcaagaaac aatataagta catatttaaa
    43381 ccaattattc aatgagggta tggttacgaa gataaaagga agacctgtgt attatatccc
    43441 tgcaaatctt aaccttaaca agaatgaatt gcttgataca caaagtgagt tgcttggcat
    43501 aaaaaaagga acaaaagtag aaaacaaaat aaaaaaagat agttttgaaa cactaatagg
    43561 taaagaacat agtttaagac ctataataga aaaatgcaag gtcgcaatgc tctatcctac
    43621 aaatggactt catactatta tctatggaga aacaggagta ggaaagagta tgattgctag
    43681 atatatgtac gattattcta tagatagtgg aattagaaaa aataaagctc cttttgtaac
    43741 atttaattgt gctgattatg ctaataatgc acaattactt atgggacata tttttggggt
    43801 agaacaagga gcttatacag gtgcagaatc ttccagaaaa ggtcttttgg aaattgcaaa
    43861 tggagggata ctatttttag atgaaattca tagactacca gcagaaggtc aagaaatgtt
    43921 gtttactttt atagataagg gaacatttaa aagactagga gatgcaacga aagaaagaga
    43981 gtctaaggta ttaataatat gtgctactac agaaaatccg acatcaacac tattagatac
    44041 attcaataga agaataccaa tgaaaataga aataccatca ttgagagata ggacaatgat
    44101 tgaaagaatg gaattagtca aaaatttttt caaggaagaa tcaaaaagta tttctatttc
    44161 aataaaagta cataaagaaa taattaaatc actattactt tatgattgta aaaataatgt
    44221 aggtcaactt caaaatgata taaaattagc tgttgcaaat ggatatctaa gatataaaag
    44281 agataataaa gaaccagttt atatagagaa aaaatatttt gataaatcta taaatgaagt
    44341 gagtgatgat tatagagaga agtctattaa agcagatgaa gttataacac atggaataga
    44401 atattttgta tttacgtcat taggagaaga agaagttatt aactacaatg atataaatat
    44461 tattaatgca gtaaatacta atcttaataa atctgtagaa atgaatatag cagatgcttc
    44521 tctatttaat aatgttaagt ttaaaagcat gtgtgaatca ataagacaaa ttattaaaga
    44581 agatgaagaa atagacataa gtgaatcaat atttaagtca atggcaattt atataaaaag
    44641 cgtattggat aaaagtagct ctacaaacaa catagatttg aatcaaatta gaagaaataa
    44701 cagaagtgaa tttaaaacag cattaaaaat agttggaata attgaaaatg aatttgattt
    44761 atttttatct atagaaactg tagcatatat tacattattc atagtacaag ctaaacaaga
    44821 tgaacaaaat aaaatagtga ataacattaa tattatagtt gctatgcatg gagaaactac
    44881 agcaagtagt atggtaaaag cagttggtga tattattgga aagtgcagtg ctatttcttt
    44941 cgatatgaag ttagataaaa gctatgatga agtaattgta gattttaaaa atttaattaa
    45001 taatatagac aataaagatg tattactatt tacagatatg ggttcattaa actcttttga
    45061 tgaaattata aagaaagaaa aaaagtgtgg agtaagagta attcctatgg tgacgacatt
    45121 aactgtgtta gaagcagttc agaaggccaa tatgggatta cctttaaatg acgtatacaa
    45181 ctctataact aacacgagaa agtactattt tggaactaat gaaattcaaa ataaagaaaa
    45241 tctgtctaaa acaattatta tagcatcaca tgtttcagaa ggtgtagata ataaaacaag
    45301 aaaaatatta gaagaaaaga tgagtaggta cttagatgga atagatatta tatctgtccc
    45361 atataaaaca gaaaaagatt taagtttaaa tattacgaaa cttaaagaaa gtagtaatat
    45421 tgttgcagta atcaatgaac aaagaattaa tattagagga attgactata ttagcaaaaa
    45481 agatatagat aaggatgaaa atatcaataa attaaaaaat attataaaga taagtatagg
    45541 ttatgatgat gtagttgaag gtttaaagac atccttaaaa agctctaatt ataataggat
    45601 atttaaaggt ataaaatatg tgtctgatga attgttttta gtatttaata tagaaaagaa
    45661 atacgataaa gtaattggac ttatgatgca tttagctttc atggtagatg ggttgattgg
    45721 aaatactaga gaaattgaaa agcttgataa agaaaaaaca cttgattatc acaagagtct
    45781 aagcaaaata aaagatatag tatctcaatt agataaaaaa tataatatag aaattaatga
    45841 aaaagagtgc tatcaaatat tattaatatt agaatatgca gaaataatcg aaaaagatta
    45901 ccaatgagta taaaaactta tttggtaatt ttttttagtc taaaataata ttaatattag
    45961 acacatataa atatacttag acaaagtatc taagttttga tgataaaaat gattgaaata
    46021 acagtgtttt aaagtgtcta aaaaaactgg cataatactt gcttatatta ttaaatgagc
    46081 aatataaata attaaaattt aaataaaaag gagtaaataa tatgcaagat aaaatattaa
    46141 gagataaaaa ggcaaatgac ccatgggcaa gaatgactac aagaaacgga tttagtgcag
    46201 acgaaataat atcgtcattt caaaaagcta taagaagaaa tatggtggaa gaagcttgtg
    46261 aatttgctta tgaactatat atatcatcac cagaattaga agataagcta tggagaagga
    46321 tacttacaat atcagttgaa gatataggaa tgggggaccc atcagctgta ataatcataa
    46381 ataatttaaa tcaagtaaga aaggaatatt catatgcaga tggagacaga cctttatttt
    46441 tcatacatgc aataagatat ctttgtgcat gtgagaaaga tagatcaagt gatttattaa
    46501 aaaatataat tataaaagga tttgcaatgg gtaaagttcc agaagttatg gacgtggcac
    46561 ttgacaagca tacatataga ggattagaaa tgggaaggga ttcattccac tttttaaatg
    46621 aagctagtat agtaatacca gaaaaagaag tagataatga ttataaagaa agatacttaa
    46681 aaatattaga aaaatataag caagaagaag ttatagatac ggctttcaag tttaatcatt
    46741 ggcagtacta agaattagag taaatattaa taagaattaa aataaaataa taagaattaa
    46801 agtaaaaact gataggaatt agagtaagaa ttggctgata aaaaattaga aaacaaaaga
    46861 ggttagatat tgtaggaggg taattatgaa tattttatta gtatgtgcaa atggagcttc
    46921 aacaggtgta cttgtggaaa agatgaaaag tttttgtagt gagcatgaaa agttaaaaac
    46981 taaaactata aatatagagg caacatcatt tgaaaattta aaatcataca ttgaagctaa
    47041 tgatacagat gtagtacttg tagcaccaca aattaggttt aaggaagatg atgtagttga
    47101 agcttgtaag aattacaaaa tagcagttgg tttaatagat actaagcatt atggtcgtat
    47161 ggatgctcct tctgttatga agtcggcaat cgaattatat aaaaatagat aattgggggg
    47221 aataaaaatg gaagcacttc aaaataattt aagaagattt cttcttccaa tagcacaaaa
    47281 gattgaaaaa caaaggcatc ttcaagctat aaaagaaggt atgataagca ttaccccaat
    47341 aataattgtt ggttctttaa gtatgttatt tatggcatta aacaatatgt tacctgaagg
    47401 aagtgcaaaa acattattat ctgaaaatat ggatacatta cttatcccta ataaatttac
    47461 tatgagttta ttatctatat attcagcatt ttttatagct caggcactag ctaaaaaata
    47521 taatcttaat catgtagaaa taggtatgac agcagttgtt gcacaacttg ttgtatgtgg
    47581 acaagtagta gatggtgtat tagatacaag ttatttagat gcacaaggtt tatttgtaag
    47641 tatattagta gcacttttag tagttgatat tactaagttt atgaatgata aaaatctcgt
    47701 aattagattt ccaaaagaag tacctagtgt agtaaataaa agttttagaa acttaactcc
    47761 aatgatagta tgtataatgt tatttacagc aatagcagca ataactaaaa atgtctcagg
    47821 tcaaccacta ccagctatta taatgaattt cttagcacca gctataagca gtgtagataa
    47881 tgtttttgca gtaactataa tactatttat aactcaatta ttatggttct ttgggcttca
    47941 tggagcagca ataacttcaa gtatatggat gccaatagca gctacatata tggcagaaaa
    48001 tgcaacactg atagcagcag gaggagaccc aaaatatgtg tttacaatag gattttacta
    48061 tggtttcttg caagtaactg gttcagggat aactttggga ttagtgtacc ttatgtcaag
    48121 aagtaagtgt aagagtttta atagtatggg aaaagttgtg attttaccat cactatttgg
    48181 aataaatgag ccagtaatat ttggaacacc aatagttatg aacccatata tgtttgtacc
    48241 atttgtattt ggacctgtat tggttggagc acttaatttt atggcattaa aagtaggatt
    48301 agtaggatta cctattgcag aaccaccagg ctttttacct ccaggggttg cagcattttt
    48361 gatgacatta gattggaagg caatcgtatt agtatttgca agtataatac ttatgacctt
    48421 gatatattat ccattcttta agataatgga gaaggaagaa ttaaataaaa atgcagaatt
    48481 agctacaaca ttagatgatg atagctttga tttttaacaa gtcattagaa ggagaaggat
    48541 atggtacctg aaatggaaga aaaagtattt agtataatat cagaagcagg agatgctaaa
    48601 agtgatgtaa tgatgtctct taaggaaata aaaaaaggtg actacaataa agcaaaacac
    48661 cttttaaatt cagcctcaga gaaaatacaa acagcatcaa agcatcattt agaattacta
    48721 tcaaatgcta tgaatagtga agatagtggg actgattttt tagttgtgca ctctgaagac
    48781 cattattcaa atgcattatt tgctcattct ttagtatctg aacttgtaga tatatttgag
    48841 atgatggacc caagaattaa taagaattaa atttcttgta aatagtgctt gaagtttggc
    48901 tatagtttat taaatcaata gatttaataa atgaactccc ttttacttta aagtactagt
    48961 atttataaat ttatttataa atacagtaaa tttttaaata gaaaaggaga tattattatg
    49021 gaaaaatttt cagtagtaat agctggagga ggaagtacat ataccccaga aatcatatta
    49081 atgttgctag ataacttaga taggttacca ttaagagcaa tcaaattata tgataatgat
    49141 gaagaaagac aaaataaggt agctaaagct tgtgaaatac taataaagga aaaggaccct
    49201 aatatagagt atttagcaac aacatgccct aaagaggctt atacagatgt agatttttgt
    49261 ttagctcata taagagttgg aaaacttgaa atgagagaac tagatgaaaa gatacctcta
    49321 aaacatggag tagttggtca agaaacttgt ggaccaggtg gaatagctta tggaatgagg
    49381 tctatagaag gtgttcttga aaacatagat tatatggaaa agtattctcc aaattgttgg
    49441 atgttaaatt attctaatcc agcatcaata atagcggaag ctgttagaag attgagacct
    49501 aattctaggg taataaatat ttgtgatatg ccaataggta tggaacataa tatagcaagg
    49561 attgcaggac tcaaatctcg taaacatatg gatataagat actttggatt aaatcacttt
    49621 ggttggtata cttcaattaa agataaaaaa ggaaatgaac ttttaccaaa attagtagaa
    49681 catataaaag aatatggttt tataaatggt gaagaaggaa tgaaaaatga caagaaagat
    49741 agttggtttg aaactaattt atttactaaa gaaatagtaa aaacagattt aactacaata
    49801 ccaagtagtt acttaaagta ctatctattt ccagattatg ttgtaaatca ttctgatgta
    49861 aattatactc gtgccaatga agttattgat ggaagagaaa aagaagtttt tggttcatgt
    49921 gcattgatag aaaagcaagg acattctaag ggcagtgggc ttaagatagg aatacatgca
    49981 gagtttatag tggatttagc tacagctcta gcttttaata cacaggagcg tatgttattg
    50041 atagttcaaa ataatggagc tatagaaaat atacaagatg atgctatggt tgaaattcca
    50101 tgtatagttg gaaaagacgg gtatgaacca ttatcaatag ggaaaatacc aacattccaa
    50161 aaaggtttaa tagaacaaca attagcagtt gaaaaattag tagttgatgc ttggattgag
    50221 aagtcttata ataaattgtg gcaagcactt atgctatcta agacagttcc tagtgcaaca
    50281 gttgcaaaag aattactaga tgatttaata gaagcaaata aaaattattg gccaaaactt
    50341 aattaagaat aatatatttt taaagttcct acagtttagt acatagctta gttaatgtat
    50401 ttgtagggac tttatttatc tacaaatgag atacaagtgg aaaacatagt gtattttgca
    50461 gttaggaaag taggtttagt tacttgttag ttggattaaa tttagataca ataatttact
    50521 atcaatcaat agaaataacc agagaagttg cataataaaa aatttacact tttaacagga
    50581 tttatgtagg tgtttataga aataaataaa tatgtacata aatacataat tatttttaag
    50641 tctaaaatac aagaatggag agatggctat gaagtggaga gattatgctg atgatgtaaa
    50701 tttatttgag gattttgata aaactatcaa gcctctaact gacgaacaaa gaagaaaaaa
    50761 tataaacact ttaattgcat atttttcaaa agaagttcct tctaaaatat acaatttatc
    50821 aaatgatgaa attaagccta gagatatact tagaggactt ttgaatgtat atccaccaaa
    50881 agaaattgct ccagagatac ttaatatgtt acataattta ttgttgattg aatgtgaaga
    50941 aagagagtta atagatgtaa atgatataga agaagtagag gaagggattg ccatatggag
    51001 aggtaatata acgaatttaa gagcagatgc aatagtaaat gctgcaaata acaagttatt
    51061 agggtgttta caaccattac atctatgcgt ggataatgag atacattcat gcgcaggtcc
    51121 tagacttaga gaagattgtg acaaaataat aaaaaaacaa gggcatttag aatatactgg
    51181 agatgctaag ataactagag gttattgttt acctgcaaaa tttgtagtac atactgttgg
    51241 acctattgta tctggtggtc agccaagtaa agagcaagaa aagcaactgc ttcattgtta
    51301 taaatcatgt ttaaatacaa taaaagaaat tgatgaaata aaaaatattg ttttttgtgg
    51361 aatttctaca ggtgtatttg gttatccaaa aaaagaggca gctaatcttg ctgtaagtag
    51421 agttagacta tggctaaaag aaaatcctga aaaaaattta aaagttgtat ttaatgtgtt
    51481 tactgaagaa gaagaagaga aatatagaag aatatttaaa taatattatg taacagaatc
    51541 ctaaaaatac ttattatata a
//
LOCUS       DAEQCW010000015        47191 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.015, whole genome shotgun sequence.
ACCESSION   DAEQCW010000015 DAEQCW010000000
VERSION     DAEQCW010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 47191)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47191)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47191
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.015"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            136..657
                     /locus_tag="KRO40_000938"
     CDS             136..657
                     /locus_tag="KRO40_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091769.1"
                     /translation="MDIAKLILNPARLRILQYIRLYGSVRTSDIVKYLNDIPRATVYH
                     HVKILEENNMIEVIKENRVRGTIEKVYALKEYTTSMEGETFVALSTAFYVGLMQEMNE
                     YFSRKEQDHKKDNVFFSSALLYMSDNEYENLLKSIADLLKPYIEQKPKSNLKLRKLSI
                     ISSPPVADNDKTK"
     gene            691..1467
                     /locus_tag="KRO40_000939"
     CDS             691..1467
                     /locus_tag="KRO40_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2091770.1"
                     /translation="MKFHEFGNKNRPHIMLIHGGGNAWWNYLRQAEVLSNKYHVILPT
                     LDGHGEEYETTYISTEDTADKLISYIDENCSGHLFALCGVSLGGQIVMELLSRKPNIT
                     KKAIIDGSICYPRPLMARFCIAGIRFFGGLLFSEKACRFQIAMMPKLLPENMQYPDEI
                     KAYYMTDMPHVRKETFYNMYRTYMMNYTLKENVKKTTAQVMYWYGEKEMKCVKKSAKL
                     FQSYVPSCEIYEAKSYNHGYLSLYLPNEWLEIAEPFFQKE"
     gene            1809..2762
                     /locus_tag="KRO40_000940"
     CDS             1809..2762
                     /locus_tag="KRO40_000940"
                     /EC_number="3.4.24.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GPR endopeptidase"
                     /protein_id="HBH2091771.1"
                     /translation="MISVRTDLALEASEMCEKSQEGSSIPGVKIETKELENCIVTKVE
                     VIDRQGAEIMNKDIGKYITLESNLMKFDDDESREEMISYLKEELVDIFGQDKNKKTLV
                     IGLGNRNITSDALGPKSVSKTLVTRHLFKNYNKDYDDDFTEVSALSPGVMGVTGIETS
                     EIVKSLVEKVKPDRVVAIDALASRKMERVNSTIQISTAGISPGGGVGNTRKSLTKETL
                     GVDVIAIGVPTVVDAATLTIDVLDMAIDNLIAQSEETESFYEMLKKLKEEEKYHLIKD
                     SLDPYDKNLIVTPKDIDDTIENLSIIISEGLNRSLHPGRLV"
     gene            2780..3799
                     /locus_tag="KRO40_000941"
     CDS             2780..3799
                     /locus_tag="KRO40_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein P"
                     /protein_id="HBH2091772.1"
                     /translation="MFKKCIKVVTLTFILVCILPGKSLALNQDDFLKFLVNSSYPEAK
                     VEGNDTENKKNNKNKETSKENKEESKEGNTKSKDASKVDNKKESEKEYIKLYVGKENV
                     PDIESKNSDTTETNTTSSSDYKDDLRVTKENPRILIYHTHGCETYSNSPDGNYHSRDK
                     KNSVMEVGSALTSALDSKGWGVVHTTKYHDYPSYNNSYASSLKTIQSILPKYNSVDIA
                     IDLHRDARDLTNPATKEKDHLKYTTMINGERVSKFFFVVGGKNTNRKQLRALAEDITA
                     FAEKKYPGLVSPIVEKDYARFNQFAVKNHMLVEIGNNATSVEESKATTKYLAEILDEY
                     FKQKN"
     gene            3830..4081
                     /locus_tag="KRO40_000942"
     CDS             3830..4081
                     /locus_tag="KRO40_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091773.1"
                     /translation="MSRLEKNIESKSKLRKYKYIMRILFLITMIICTSVCVFIVDSNA
                     KSMLGMKQYDFPSIKFDITKFDFDIPNFDIHEIIKKFNK"
     gene            4363..6168
                     /gene="lepA"
                     /locus_tag="KRO40_000943"
     CDS             4363..6168
                     /gene="lepA"
                     /locus_tag="KRO40_000943"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HBH2091774.1"
                     /translation="MDNKQSRTRNFSIIAHIDHGKSTLADRLIQQTGLVSERDMKSQL
                     LDNMDLERERGITIKLQNIRLMYKAKDGNEYYLNLIDTPGHVDFNYEVSRSLAACEGA
                     LLVVDAAQGVEAQTLANVYLAIDQDLEILPIINKIDLPSARPEEVKNEIEDLIGLDSS
                     EAPLISAKTGLNIEDVLEDIVKNVPPPKGDNEAPLKALIFDSYYDAYKGVVAYVRVFE
                     GTVKKGMTIKMMNTNKKFEVTEVGVMAPGQTELSELSAGDVGYIAASIKDIRSCRVGD
                     TITDSNNPTEEPLPGYKKATPMVYCGIYPGEGEKYENVRDALEKLQVNDAALEYEAET
                     SAALGFGFRCGFLGLLHMEIMQERLEREFNLDIITTAPSVIYRVTKMDGEVVMIQNPA
                     NLPEPSEIKMIEEPIVKGDIIVPKDYVGVVMELCQERRGNMLNMEYIDDRRVMLHYDL
                     PLNEVVYDFFDALKSRTRGYGSLDYEVKGYVASTLVKLDILINKEQVDALSFIVHETR
                     AFPRGKAMCEKLKGEIPRHQFAIPIQAAVGNKVIARETISALRKDVLAKCYGGDISRK
                     KKLLEKQKEGKKRMRQIGSVEVPQKAFMSVLKLDE"
     gene            6317..7654
                     /locus_tag="KRO40_000944"
     CDS             6317..7654
                     /locus_tag="KRO40_000944"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HBH2091775.1"
                     /translation="MINIEIPKKVDYIIKELEKNGYEAYIVGGCVRDCLLERVPNDWD
                     ITTSARPEVVVELFEKTIPTGIQHGTVTVMIEHEPFEVTTYRIDGNYSDGRHPDSIEF
                     TNNIVKDLSRRDFTINSIAYNSKTGLVDPFNGYEDIQNKYIRCVGNPVDRFEEDALRM
                     LRAVRFSAQLNFKIAEGTKQSIHKKADLIKNVSIERIQTEFNKILVSDSSKLNLLKST
                     GLLKFIIPEICELEDVTQHNPYHIYDVQKHTLIATEAIEDELYLKLTMLFHDLGKKVT
                     KTTDKNGVDHFYTHSRESVKIAKKILKRLKYDNYTINKVLILIQYHDYRIEPKRKIIK
                     KLLNKLEDVELFEDLIKVNWADTLAKNPKYAKQKILNLIECEKEFKHIINQKECFNLK
                     DLAINGKDLISIGIKPGKDIGHILNKMLEIVINNPELNEKEILKEKALNIYTF"
     gene            7887..9200
                     /locus_tag="KRO40_000945"
     CDS             7887..9200
                     /locus_tag="KRO40_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2091776.1"
                     /translation="MHTQLQKTIGLSAALSTVVGMVIGSGVFFKPQAIYTTTNGAPGL
                     GIIAWLLGGFITITAGLTATEISAAIPKTGGMMIYIEEIYGEKLGFLTGWMQTVLFFP
                     GTSAALGVIFAQQASELLGMSPNNMANVLPIAVGVILFLALLNIIGSSLGGKVQTVAT
                     IGKMIPLILIIVFGFIKGQSSEVLNPFVGDGVNASNALGQVLIATLFAYDGWINVGAI
                     SGEMKSPEKDLPRAIVGGLSLVMAVYIIINIAYLWVVPASELATVTSPATLVATRLFG
                     NIGGKVITVGILISVFGTLNGYLLTGSRIPYTLAEMGTLPASKTLLKVNSGGSPVNSI
                     LLITVLACVYALSGQFNLLTDLTIFSIWVFYVLTFIGVMRLRRQKPDLHRPYKVPLYP
                     IIPIIAILGGLFVIINQILTSTVISLGGIFITLLGLPVYYYMKKR"
     gene            9372..10547
                     /locus_tag="KRO40_000946"
     CDS             9372..10547
                     /locus_tag="KRO40_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HBH2091777.1"
                     /translation="MLGLYVHIPFCVKKCKYCDFNSYKMDIDSKKRYIEDLKIEMELY
                     SNKLYKDNKYKNKECCSLNKNDKITSIFVGGGTPSILTSDEIREVFISIKEMFDIDEN
                     AEITIECNPGTLTLEKLKTMKEIGINRLSIGLQAIQEKHLNFIGRIHTYEEFEKNYKD
                     ALSVGFKNINIDLMYSLPNQTLCDWKETLEKVVHLNPTHISAYSLILEEGTELYNMYE
                     SNKFELIDENVDIEMYEYTINYLKSKGYNQYEISNYSKEGYNCEHNILYWECEHYIGI
                     GAGASGYINENRYNNVESLEDYHLSLVKREKPIQENEILSEKDMIEEKIFMGLRMNKG
                     IKFEDFKKKFGIDFREKYNKQIEMLLARKLINQSFEGIQLTQKGREISNSVFIEFME"
     gene            10650..11669
                     /gene="hrcA"
                     /locus_tag="KRO40_000947"
     CDS             10650..11669
                     /gene="hrcA"
                     /locus_tag="KRO40_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcription repressor HrcA"
                     /protein_id="HBH2091778.1"
                     /translation="MELNERKLNILKAIVKDYIETAEAIGSRTISKRHDLGVSAATIR
                     NEMADLEELGYLIQPHTSAGRVPSEKGYKLYVNSLMSKSELDDNDKILIEQCMNHNIN
                     HIKELIHETSKLLSQLTNYTTVAVTKSLINQSVIKHIQLVAMNDNNILLIVVTDKGDL
                     KKANLTTNVYLDQSKLNLISDNLTRKLLGKSITDLDDNLIAFIKYEISEYSGLIDELL
                     NALNSNMKEEDFSLSLNGATNIFSYPEFNDVLKAKSFLNMLEKKETIADIIKSKGIQK
                     DNLNIIIGSDNDCELAQDCSIVTATYNVDRDLVGRISFIGPTRMDYARIYSIINYMSL
                     LINRK"
     gene            11699..12319
                     /gene="grpE"
                     /locus_tag="KRO40_000948"
     CDS             11699..12319
                     /gene="grpE"
                     /locus_tag="KRO40_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HBH2091779.1"
                     /translation="MDKKNEQQEVREENDTSINQESETQVELEEEVVNEECETSSEKT
                     DEKEVDDENVTDINSKLAEKKLQDELDELNDKYQRLQAEYANYRRRTQQEKETIGVFA
                     NEKIITELIPVIDSMERALDACEDKEDTMYKGISLVHKQLIDTLVKFGVEEIEAESKE
                     FDPNLHLAVMQESVDGVEANQIVMVLQKGYKLGTKVVRPSMVKVSC"
     gene            12411..14258
                     /gene="dnaK"
                     /locus_tag="KRO40_000949"
     CDS             12411..14258
                     /gene="dnaK"
                     /locus_tag="KRO40_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000034699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HBH2091780.1"
                     /translation="MGKIIGIDLGTTNSCVAVLEGGEAQIIANSEGMRTTPSVVAFTK
                     DGERIVGEPAKRQAVTNADKTITSIKTHMGTDYKVNIDGKSYTPQEISAIILQKLKSD
                     AESYLGQTVTEAVITVPAYFTDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGMDKL
                     DQEKKILVFDLGGGTFDVSILEIGDGTFEVLATAGNNRLGGDDFDQIVIDYLAEEFKK
                     AEGVDLRNDKMALQRLKEAAEKAKKELSSTMSSNINLPFITATAEGPKHLNIDLSRAK
                     FEELTRGLVEKTMEPTKTALQDAGLSTGDIDDVLLVGGSTRIPAVQEAVKKFIGKEPH
                     KGINPDECVAAGASIQAGVLAGDVKDLLLLDVTPLSLGIETMGNVMTKIIERNTTIPT
                     KKSQIFSTAADNQTAVDIHVLQGERSMAYDNTTLGRFQLTDIPPAQRGIPQIEVTFDI
                     DANGIVNVSAKDLGTGKEQKITITSNTNLSEAEIEQKIKEAEMNAEADKQKKEKIEAF
                     NQAESTIYQTEKTLNELGDKISSGEKEDIEKAIADLKAVKDNQDATAEELKKATDEVM
                     TKFQKVSQEMYQKAAQEQQAAQGAEQAQDNGPKDDNVVDADFKEVDEDK"
     gene            14469..15623
                     /gene="dnaJ"
                     /locus_tag="KRO40_000950"
     CDS             14469..15623
                     /gene="dnaJ"
                     /locus_tag="KRO40_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HBH2091781.1"
                     /translation="MSTKRDYYEVLGISKGAEAQEIKKAYRKLAMKYHPDRNPGDKEA
                     EEKFKEINEAYEVLSDDTKRKTYDQFGHDGLNGQGGFGGQGGFGGQGFGGFEDMFGDI
                     FGDMFGGSFGGGRARRRGPQRGADIRQSVTISFEEAAFGKKMSIKVNRSEECEECNGT
                     GAKPGTSKKTCSTCNGTGQVRTVQRTPFGNIASSRPCSACNGTGEVIESPCSKCHGTG
                     NTRKVKTIEVDIPAGIDDGQMIKLSGQGEVGEKGAPRGDLYIVVNVKSHPLFTRDGND
                     IYFEMPITFVQATLGDEIEVPTLDGKVKYSVPEGTQTGTVFRLKEKGIPRIRGNSRGD
                     QYVKVVVEIPKKLNDKQKELLREFAKECGSNVHEKKKTFGQKIEDMFKKK"
     gene            16589..17524
                     /locus_tag="KRO40_000951"
     CDS             16589..17524
                     /locus_tag="KRO40_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBH2091782.1"
                     /translation="MYYIGVDIGGTGIQAGVVDNYGKIIFRSECKTVIEKGFEGILND
                     IKIMIYKLLEDNKLTMSDIKSIGFGVPGFINKEGLVTCVNLKWNKKAFNKELKRRFPD
                     VEIHGENDATVAALGEAKFGSMKGANVGVLYTLGTGVGGGIVINQKVFSGAHGLGSEI
                     GHQIIGENYFNCNCGNNGCVETFCSATAIIKYSQKLIEEGEKSRILDLAEGNLENVNA
                     KMVFDAYRENDLVAIKVINRFKEYLAKTFANTINSLDPEIISIGGGISKSSDIILDGI
                     EDLVRKFVLYKTEDIATITCATLGSDAGIIGAAFL"
     gene            17560..18933
                     /locus_tag="KRO40_000952"
     CDS             17560..18933
                     /locus_tag="KRO40_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2091783.1"
                     /translation="MGKTNARRTLFLIAIGSGTMLNPLNSSMISLALHSIQNDFHISF
                     TTVSWIVSAFYLASAIAQPVSGKIGDLIGRKVLFLSGLMLVILSASIVPLVQSFFILI
                     FIRVIQAIGTSTLYPSGVALIQNNIKERQSSALAVLTIFASTTAGLGPTLGGLLLDLG
                     GWHAIFLVNIPVVLVSICLGYFLFPKEVKEKKSIKETLKNVLSRLDIIGILLFSIAMI
                     FILLFLLSMKESFNLEQLIFGIILMCLFIWHELRTKLPFIDIKLFVSNPKLSKVYLQF
                     IILNFFNYILFFGLPSYFQDALHYSAKSTGLFMLFMSGIGIFISPLTGKWIDKSGTRF
                     PLVTSSIFMFISAVLLSVVFIHIPVIGKGIILSLAGISYGVGNVALQSSMFEESPRDS
                     IGTASGLFQTSRYLGSILATVLLGMVFEVNITSEQFQILGYVMVVLGTISFLLNFILK
                     KELRKVE"
     gene            complement(19121..19888)
                     /locus_tag="KRO40_000953"
     CDS             complement(19121..19888)
                     /locus_tag="KRO40_000953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091784.1"
                     /translation="MEELKDFLERQLNKKINIYPYENQKLDASSHLVTFNNAIYVIDF
                     LDKNNLDNLKGNFYLIYQSHIDFEYLKNIFYNLFEDINIIQHNGFFIVNSKYNLDINV
                     TTQNIIETETYQSTYIFYLGKLDSKADFDFRLQLCSDLLPHIIKDNAENKFLNLFDLI
                     RYKTLDLINEDNILNKLIDFNKIKSIDEELLYTGIKFINNDLNISKTSTSMFLHRNTL
                     VYRLEKINEILGFDLKNFENAMIFYLSVKSYFLYKKI"
     gene            complement(19918..21027)
                     /gene="ugpC"
                     /locus_tag="KRO40_000954"
     CDS             complement(19918..21027)
                     /gene="ugpC"
                     /locus_tag="KRO40_000954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003242648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HBH2091785.1"
                     /translation="MSEVILKNISKLYSNGFNAVKNINIDIKDKEFIVLVGPSGCGKS
                     TTLRMIAGLEEISEGELYIGDKLVNDIEPKDRDIAMVFQNYALYPHLSVYENMAFALK
                     LRKLPKDEIDKKVKEAAKILDLLPLLNKKPKTLSGGQRQRVALGRAIVRNPKVFLMDE
                     PLSNLDAKLRTAMRTEITKLHQQLGTTFIYVTHDQVEAMTMADRIVVMKDGVVQQIAT
                     PQDVYDYPANIFVAGFIGAPQMNFIDVILIEENDEIYAQNEHIKLKLNKEKHYDLIKD
                     NYINNEVVIGIRPEDIHVEDTFIKSNPDTCFKSRIEIKELMGAETYAHLKLGENTITI
                     RFDSKNRINVGDDLTLSVDNSRVHIFDKETTLAIR"
     gene            21285..22022
                     /gene="cas6"
                     /locus_tag="KRO40_000955"
     CDS             21285..22022
                     /gene="cas6"
                     /locus_tag="KRO40_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBH2091786.1"
                     /translation="MSRISIFMESCNGKFPNENSMLSVSFIKNILNAENKDFAKNIFN
                     YGKERKNNKQIKDINTAIYIPNLIRSKNELLVDGDIIFNISFYNYSMFSKLYNGILKV
                     KELEYKGYRFKIKNIKIHKEHEIKENGVIFKTMSPIIVKNKEGKYLDVEDSNYIECLN
                     YIANLTLESIRGSGLRKPLEFIPLNFKKRVLKEKIRGFKVREFYYINAYAGTFFLKGD
                     MEDLNALYKMGIGYRRTENAGMVDILK"
     gene            22027..23502
                     /locus_tag="KRO40_000956"
     CDS             22027..23502
                     /locus_tag="KRO40_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091787.1"
                     /translation="MREIKAKFYRSGDIVRDIGIVYFYELLMDLKNELEKNDYKLKFT
                     CELNRNYLSLESAEYIDPKYISDYILENQLFKVFKNGKKETLEKIFSNIDNLTYVNFI
                     EELDKSSATAKQKEDIKKDFKNRRFPYVRNSGKYGLNTSLENMETNVKRIVDTVIKSN
                     IEIDEIDKLDLTQYEEKDSVCNVCNINKTTKLDIDLRERKDSKYNFLFRGAEKSGFKR
                     SGQVESNICFECEFFNLMCLLYINLKRPMVFAYTNDLRELAFLNHKIMLKRKMYSDKS
                     FYKKLLHEKISSIRLYRFDIVKNKGIILKFDSIIEYKELLKKIELIDIIDNYNFSREP
                     VNTKNLGKKMIDNGNLSNLKELLLDNISFLKQSTGTSREMDFVSSSYNIGLYIKLCWI
                     VDGGEEYKMKNYMESNLIYSRVGKDLFNKMTDESRRKNFSMKVIQLLKSNDRTQLFQT
                     IMHVLVSNGILIGEGFVEGLMQSSELELNTNVGLFIQEIMK"
     gene            23522..24535
                     /locus_tag="KRO40_000957"
     CDS             23522..24535
                     /locus_tag="KRO40_000957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DevR family CRISPR-associated autoregulator"
                     /protein_id="HBH2091788.1"
                     /translation="MNEKRVKGVTLTILTESPVPLSYDQGYGNYTPIKKEQYREKIHA
                     KTSIATITYDLRRMLHQEYGWNLSNIVFGKKGNIYPSIKKNVGCVDENGLETDVFGYL
                     IPLKDKGSISKASPLRIIPFRSLNPYIGSTQLITNRGFLSSEFGRKYYDEKEENEVPR
                     DENFPTTQALAIEETLSDYYVYTITLELDRIGVVEVEDGKLLLPEERKFMSKELREKA
                     VKDILDAITVFTRNIKHSSVLLKPLAVIGGAFDKVVPFFWDDVDYNADSGEINLEGVI
                     ETIESYSLKESNTILAINDRLKISNKKELNKFNLSKYPVKEIKNLADRLEIGEDNMWY
                     LKE"
     gene            24551..25348
                     /gene="cas5"
                     /locus_tag="KRO40_000958"
     CDS             24551..25348
                     /gene="cas5"
                     /locus_tag="KRO40_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas5"
                     /protein_id="HBH2091789.1"
                     /translation="MKVLQCKLKQPTAHYRDPKVFQNEYISTLNLPSKTTIMGMITYL
                     CDRRLNSDIDIGIIGTHHHRELEFSRGENIDFWNEYTNMRKGKDKEKFLLQGNYYDYY
                     KEHKAQNSILNYEVLKEVELTIFISCKDDEELEFIKKKLESPCKYANLGRKEDFVIPS
                     EKGCFVKEVELKEVIPMNTRDAIKENIKLKNTYVRVDLRDKENVETIINQGVLIALPH
                     KYKDLEANRDDRVYEFCHYIYVDNDGIYPKNIKVNVCIDTKEVFTWL"
     gene            25375..27783
                     /locus_tag="KRO40_000959"
     CDS             25375..27783
                     /locus_tag="KRO40_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="HBH2091790.1"
                     /translation="MKNIMQKEILAKSYNLRTNQQEQTLVEHIKDLFEVLESILELNL
                     YSDKDVEILKICCALHDLGKINSIMQQKMEINNKISYSCSEEERKKLESDKKSLKKIA
                     RHNIFSGAFLKDILEKMNLSEEDKLYIYKSIMLHHGNYEDYMRLSISKVQEEIYEYIE
                     KGILEKEEFNLKDIESYINNILNVDFKFGEDVLDYDYIDKLSESMFIDSDYNNGQIDD
                     SVLNYRKFKYILYKGMLNLIDHSASSRQKGIKFYNDFTDEEIDNMILNEIYKSQGNLE
                     KNNIEFNTIQKRLRELSGRNVLTVAFTGSGKTAADYRKTFKRKFFLVPNKISAESFYR
                     KNIFQNKNDLDTRSSNDYIGLLHGDINLYSENEDNGEHDFVLTLRDIDLSINFCKPCV
                     IATVDQLLLSMFKFPGYEKIFAAVKNASITVDEVHLLEPKMFLILIYFMQFACKYLDV
                     DFHLMTATLPKSYKEQMINKGIIFQEESNKNVTDKGEIVFIESNKEEEICEGKDVKVS
                     FIKEKEIKSIVEDALENKQKILIIKNTIDSVNRTYEFLKENLSDKYGGVDIDVLHSRF
                     KFKDKKEKYSKILNGEGDIWISTQSVEISLDLDFNIIISDLATMDSLIQRMGRCNRNN
                     KYEYGNFYILPSEDKIYDNKLKNTTKNILKDILKTNSIFTMGIRKTILDDYYDNSVVK
                     KYFEENFISCDKEIKNIYGINKEIFDGLDLIFNFEPYKNIVDSKKEAAKIFRDIDVSY
                     KIILEEDFYKEDRELQQDSIQVSGFIFNRLYYYGLISKVEGYMVLKSSSKFEYNSTVG
                     LILK"
     gene            28224..29171
                     /gene="prmA"
                     /locus_tag="KRO40_000960"
     CDS             28224..29171
                     /gene="prmA"
                     /locus_tag="KRO40_000960"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HBH2091791.1"
                     /translation="MNNWIEVTIKTTTEAVEPITNILYEQGAGGAVIEDPKDFLFQKK
                     NELDWDYVEEEVFKKNEEDDVLIKTYVSEEKNVMEFVEIIKQKVLGLKDFGIDIGEGS
                     VSLDQVNEADWANAWKAYYKPTKVGQRVVVKPTWEDYAMQEGDLIIELDPGMAFGTGT
                     HETTSMCIRELEKYVNKDSKVFDIGCGSGILAIAAAKLGAKEVVAVDLDEVAVKVAKE
                     NVLENKVEKSVSVMHGNLTDVIKDKADVIVANIIADIIKILAKDVQNFMKEDAIFISS
                     GIILDKVEEVKESLIENGFEIVEVQKLGEWSAIVSKLKK"
     gene            29190..29948
                     /locus_tag="KRO40_000961"
     CDS             29190..29948
                     /locus_tag="KRO40_000961"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HBH2091792.1"
                     /translation="MDRFFVEKNNINLQDKTCTIEGEDVKHISKVLRCKLGEKLEICD
                     KNNNEYICEIMNIDKSIVNLEILEKVDINRESELKVRLYQGLPKAPKMEMILQKLTEV
                     GVEEIILVQTKRSVVKVDDKKEDKKFERWERIIYEAAKQSKRGKIPKLRGVLSFKEAL
                     EDMKKNNVNICPYENERTVSIKHALKKCDSNIDSVGIFIGPEGGFSEEEIEQIQKNNC
                     NVVSLGPRILRTETASVVASTIALYELSDLGGEK"
     gene            29950..31248
                     /gene="mtaB"
                     /locus_tag="KRO40_000962"
     CDS             29950..31248
                     /gene="mtaB"
                     /locus_tag="KRO40_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-
                     methylthiotransferase MtaB"
                     /protein_id="HBH2091793.1"
                     /translation="MKKVAFYTLGCKVNQYETEAMLELFEKDGYEQVNSEEYADVYVI
                     NTCTVTHMSDRKSRQYIRRVKKKNPDAIIAVVGCYSQVSPEEILDIEEVNLVMGTNDR
                     RKIVEEIKKINSSKKVSTVDDIMKVKAFEEIEISQTNGKTRAFMKIQDGCDRFCTYCI
                     IPYARGRVRSRDIDSIVDEVKKLANNGYKEVVLTGIHVASYGKDLKDRDIKLLDVIKQ
                     INQIEKIERIRLSSVEPILFTDEFVNEVLKMDKVCPHYHLSLQSGCDETLKRMNRRYT
                     TLEYKTIVDRLRSKMPDVAITTDVIVGFPGETNEEFKKTYEFLKEIELSQMHIFKYSP
                     RKGTPAATMENQVDPQMKHFRSEQLLNLSKVNFNKFATKFIGRELDVLFEQNIEGNKY
                     EGLTSNYIRVVVESDKNIQGQILKVKINDVKDEYVEGILL"
     gene            31291..31641
                     /locus_tag="KRO40_000963"
     CDS             31291..31641
                     /locus_tag="KRO40_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine triad nucleotide-binding protein"
                     /protein_id="HBH2091794.1"
                     /translation="MDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKK
                     HYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHI
                     LAGKKLPNYEAGQN"
     gene            31804..31983
                     /locus_tag="KRO40_000964"
     CDS             31804..31983
                     /locus_tag="KRO40_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HBH2091795.1"
                     /translation="MSEVRVRENETLDSALRRFKRQCAMSGIMSEVRKREHYDKPSVK
                     RKKKAEAARRKNAKK"
     gene            32013..32456
                     /locus_tag="KRO40_000965"
     CDS             32013..32456
                     /locus_tag="KRO40_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="HBH2091796.1"
                     /translation="MSLKQKLQEDLKSSMKNKDTVRKSVVTLIRASIKQYEVDNRVEL
                     DEDGIIDVIAKQLKQRRDALVEFEKAGREDLIKETEGEIEVLKEYLPQQLSEEELEEI
                     VKSTISEVGATSMKDMGKIMSVIQPKVKGRADGKLINKLVKQNLQ"
     gene            32567..33064
                     /locus_tag="KRO40_000966"
     CDS             32567..33064
                     /locus_tag="KRO40_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416623.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan-rich sensory protein"
                     /protein_id="HBH2091797.1"
                     /translation="MIISVKEIRNFLINIFIPLIIGYLSSILTMIISGTDISTYYLQL
                     TKPSFAPPAFIFPIVWTILYILMGISSYLILRKGYNLPKVRDAIFYYGLQLVLNFIWS
                     ILFFGFGLRFTALIDIIIMILVSIIMISKFSKIDKRSGYINLIYLMWLVYAGFLNYFI
                     WFINK"
     gene            33257..33820
                     /gene="raiA"
                     /locus_tag="KRO40_000967"
     CDS             33257..33820
                     /gene="raiA"
                     /locus_tag="KRO40_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBH2091798.1"
                     /translation="MQIIVSGRQMKLTDGIKGYVDGKLSRLEKYLDPESEVKVTVSAK
                     KDRQKVEVTIIPINGQIIRAEDVEDDLYAAIDIVCDKLSRQVVKYKTKVKDKVQNNKS
                     IRFENLDFIDNSSEFDDYDYDDEEDENIVIERRKKFNVKPMSSEEAILQMELVGHNFY
                     MFRNQDNFEINIVYKRKAGGYGLIEQD"
     gene            34033..34269
                     /locus_tag="KRO40_000968"
     CDS             34033..34269
                     /locus_tag="KRO40_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YabP/YqfC family sporulation protein"
                     /protein_id="HBH2091799.1"
                     /translation="MLEISTDLQVNQPVITVTSNTFISIENYLSILEYEVDLIRIKTK
                     VKTIKISGDKLSLKYITDSEIGIKGIIYNVEYVD"
     gene            34282..35625
                     /gene="yqfD"
                     /locus_tag="KRO40_000969"
     CDS             34282..35625
                     /gene="yqfD"
                     /locus_tag="KRO40_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YqfD"
                     /protein_id="HBH2091800.1"
                     /translation="MISFIRGYYVIVVEGVGLEQFLNHLIRNGISVYNVTRIKNTKME
                     FHIDRQDIKDFKNVYRGSKFDIKVKQKTGVPFIIKRVYKHKGMWICALVSLFLLMSTS
                     QFVTDVYIQSPEGIKKEALRNELYKVGVRPGVYKKSIDRKEVRDHMMSKFNDVAYLSI
                     NVKGTNIFVTVTKKAESLKSTDQSNYCNVIALKNGIIEKVIPRSGKSVIKSGDIVQKG
                     DVLLNGANTKSIPEVWASTFYESTKKASYVDTVNKKTGEKKNIYTLSFYDKEFTMRKN
                     IKYKDYVVENKEKKLSIGNYTFPIKIKTSTFYETKKVEVKRNKEELKKELSEKALKEL
                     EYIIPASARIIDVKHNFKVNKNMLEYLITVQTSENIAKIYPLSKSEAERFIKEESKPD
                     EGEEEVPSNPEKRPLNDIRNEFDEDNKDNKDQNNSDENNSNQNSNNSQNNNSNNN"
     gene            35564..36679
                     /locus_tag="KRO40_000970"
     CDS             35564..36679
                     /locus_tag="KRO40_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HBH2091801.1"
                     /translation="MKIIVIKIVIIVKIIIAITTNKIKLKILGGLIQLIIQKKFTIAD
                     GNFERELFGNFDENVKLIEKTLNIDVILREGNIILIGEEKNVDSALKLMNELHQTVSN
                     GKHLDKQSISYSLSLLLEGSEQKIKELEGTIVITQRGKAVQPKTLGQKEYIKLIENND
                     ITFGVGPAGTGKTYLAVAMAVKAFKRDEVSRIILTRPAVEAGESLGFLPGDLKDKVDP
                     YLRPLYDALFEMLGADKFNKYLERGTIEVAPLAFMRGRTLDNSFIILDEAQNTTSEQM
                     KMFLTRLGFGSKAVVTGDVTQTDLPQNKKSGLIQATEILKGVPGIGSIMLTDRDVVRH
                     ELVQRIIRAYEKHDKREEFKKEERKKAKMQEKTFKRK"
     gene            36736..37197
                     /gene="ybeY"
                     /locus_tag="KRO40_000971"
     CDS             36736..37197
                     /gene="ybeY"
                     /locus_tag="KRO40_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HBH2091802.1"
                     /translation="MDLILDDRQDKLEVSEELIEKIKDIIIECLDYEGYDDNYEVSLS
                     FVDNKEIHELNREYRGVDRVTDVLSFPLLSDDFEDVELEEESLGDIVVSLERALEQSI
                     EYNHSFEREVCFLICHSMFHLLGYDHDTDENTKEMREKEEHILNKLNITRE"
     gene            37203..37922
                     /locus_tag="KRO40_000972"
     CDS             37203..37922
                     /locus_tag="KRO40_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HBH2091803.1"
                     /translation="MKPEKTRQGIIKAFNAAIEGILYTFKFERNMKIHYLGSVAVLII
                     SLFFNFSKLEMIMLLMSICLVVVAEMFNTAIEKAVDLVTDEYHVLAKIAKDVAAGGVL
                     VAALNSVVVGYILFYDKLTDISGILIYKIRESELHITLICILLVLIAVVVVKALTSTG
                     TPLKGGMPSGHAALAFAIATAITLMTERVVASTLAYIMAVLVAQSRIEGKIHTFWETI
                     AGALLGVLIAILVFQLGMFYN"
     gene            38041..38442
                     /locus_tag="KRO40_000973"
     CDS             38041..38442
                     /locus_tag="KRO40_000973"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HBH2091804.1"
                     /translation="MDNIELLRLAEDARQHSYAPYSGFRVGAALLTKSGKVYTGCNIE
                     CASLGGTNCAERTAIFKAISEGDKDIYKIAIASDNSENNEQTYPCGICRQVIIEFGSD
                     IKIITGYTKGEVFEHSIKDLLPNYFSGNDLK"
     gene            38506..39399
                     /gene="era"
                     /locus_tag="KRO40_000974"
     CDS             38506..39399
                     /gene="era"
                     /locus_tag="KRO40_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HBH2091805.1"
                     /translation="MFKSGFVSIVGRPNVGKSTLMNNVVGEKIAIMSDKPQTTRNTIQ
                     AVYTDEEMQIVFLDTPGIHKPKNKLGEFMVKAATEAFKNVDLILFVVDDSKKIGPGDR
                     KIIEDLRSVKTPIILVVNKIDQLDQKDELFDIIKMYDREGIFKEIVPISALKGKNTDT
                     LIKVIQNYLEEGPKYFPDYMITDQPERVLIAELIREKVLHYLNDEIPHGVAVEIEKMK
                     ARNDKEIVDVSAVIYCERDSHKGIIIGKNGRKLKGIGKSARQDIELLLGSQINLQLWV
                     KVKENWRNLQNYINNFGYNDK"
     gene            39411..40790
                     /gene="mgtE"
                     /locus_tag="KRO40_000975"
     CDS             39411..40790
                     /gene="mgtE"
                     /locus_tag="KRO40_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter"
                     /protein_id="HBH2091806.1"
                     /translation="MDRKLDASQDLLYEVKSLIDNNKVLELRELIEEYHIIDIFDIME
                     NLEEDMKIQLFEVLPLDMASSILEEGSVEFFISILSKLDVEHSKNILELMSLGDMADK
                     LSELEEEEREHIINLLNQENADYVKELLFYDEDSAGGTMTTGYISINKDMTALEAIDH
                     MREEAEEAETIYYIYVVDDEEKLVGVLSLRELIIARDANIVEDLMSENIISVYVDEDR
                     EEAVRLVSKYNLIAIPVVDRQEKLKGIITVDDIIDVMEEEATEDMYKFAGSSEHEREV
                     AEKENPTLREQIISALRGRLPWLIITLVGGLLASLILSNLDYIMNPVYAPLVFFIPVV
                     IGMGGNIGTQSSSVTVITLSNKDLNFSNVVREGIVGIITGLLCSIITGIVIYFVMRKL
                     DIVLIVSISLFINMVLGATIGAFMPVLLKKMDADPSTVSSPIISTALDITGIAVYFII
                     TTALLSKIV"
     gene            40863..41018
                     /locus_tag="KRO40_000976"
     CDS             40863..41018
                     /locus_tag="KRO40_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqzL family protein"
                     /protein_id="HBH2091807.1"
                     /translation="MNNISWEVFKKTGSIDAYLYFCDCKNIHEEIEEVREKKEDDDNP
                     EHPGDST"
     gene            40984..41757
                     /gene="recO"
                     /locus_tag="KRO40_000977"
     CDS             40984..41757
                     /gene="recO"
                     /locus_tag="KRO40_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HBH2091808.1"
                     /translation="MIILNTQGIVLKAIRYKESDIILTLFTRKLGKVSAIAKGAKKNK
                     SSLLSSSQLFSYSNFTLKKQGNMYKVTQSEIIKSFYNISYDIEAFSYATYITKLVENS
                     ILENQTNNRLFILLAQTLYLYTQDNTDNRFITAAFELKFLDYIGFKPIVNKCINCECK
                     ILQNSVFNIYEGGILCSKCSKLFDNNIKLDLTTISLMEYVLRNDILTCSKAKVSKYIT
                     HELENILDKYLKVYVDNINFKSLHVLQSVKNNKGVDNDE"
     gene            41750..42349
                     /locus_tag="KRO40_000978"
     CDS             41750..42349
                     /locus_tag="KRO40_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4342 domain-containing protein"
                     /protein_id="HBH2091809.1"
                     /translation="MSSNITIEMVDSVFERVPGATYAEAKEALVMCNGDVIEAVIYLE
                     NKKNTCNCKAKSAKETMEEVFGKDGENIKFQLKELLRKSSVVRIIVEKDGKTMMNIPL
                     TVGVVGLAFVPLATLVGLSAAVISKYRIKVQNEEDGEIVDLGELNEEKLHVLKNMITN
                     AAKDVKDVVVDKKEDDKDVTADLMKEESEKNKEDEDENK"
     gene            42509..43387
                     /gene="glyQ"
                     /locus_tag="KRO40_000979"
     CDS             42509..43387
                     /gene="glyQ"
                     /locus_tag="KRO40_000979"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HBH2091810.1"
                     /translation="MNFQEMILALQKYWSKQGCIMMQPYDIEKGAGTMNPNTFLRSLG
                     PEPWQVCYVEPSRRPADGRYGENPNRLYQHHQFQVILKPSPDNIQELYLESLKEIGID
                     PSEHDIRFVEDNWEAATVGAWGLGWEVWLDGMEITQFTYFQQVGNIECELETGEITYG
                     LERLAMYIQEVDSVYDLKWNDKITYGEVFNKAEYENSMYAFELCDADMLFNLFDIYEK
                     EALRLMENGLVIPSYDYVLKCSHAFNTLDARGAIGVSQRASFIGRVRNMAKTVAETFV
                     KQREEMGFPLLKDGDK"
     gene            43387..45453
                     /locus_tag="KRO40_000980"
     CDS             43387..45453
                     /locus_tag="KRO40_000980"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HBH2091811.1"
                     /translation="MKNYLLFEIGVEEMPSRFVGSTLEQLKNNLSKLFDENRIAFDKI
                     NAYGTPRRLTLVVEGLSDRQNDLEEEIKGPAKKIAVDAENNLTKPALGFIKSKGLSES
                     DIYFKQVGKEEYIFATIKQDGKETSEVLKDILPETIKSVVFPKAMRWGGKNLKFARPI
                     RWIVALLNDKVLEFDLEGIISSNVTKGHRFLGESTIEVDSIEDYFEKLEKNYIVLDQN
                     KRKEMIRKQCIEVANSLGGEVEFDEDLLEEVTYLVEYPTAFYGEFDVDYIKLPKEVVI
                     TPMKQHQRYFPVLKEGKLLPNFIAVRNGDSYRIDNVKAGNEKVLEARLADALFFYRED
                     TKRNLESYIEKLKTVVFQVKLGTIYDKTLRLEKLSADILDSLGLVDEKADTIRAAKLS
                     KADLVTGMVGEFDELQGFMGKEYAKVGGENDVVSEAIFEHYLPRFAGDILPKTNAGVA
                     LSIADKLDSIAGFFAIGIQPTGSQDPYALRRQALGILSILMDRKVAVDIKVLIEHALD
                     NYSELDFDKEEVVEQIMNFFNERVKNLFKDLGIRYDVVDAVLSSDINDVSDMHMRALE
                     LNNWLEKDELVEMLTAFNRVSTLAQKAESDKIDESLLKEDAEIKLYNEFKQVKIKVNE
                     LLKDKKYGIALDEFASLRPVVDNLFDTVMVMDNDEAIKNNRLALLKQVYDTMLEICDL
                     SKIVYK"
     gene            complement(45619..47166)
                     /locus_tag="KRO40_000981"
     CDS             complement(45619..47166)
                     /locus_tag="KRO40_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite/sulfite reductase"
                     /protein_id="HBH2091812.1"
                     /translation="MDNFKKILLNELPNFKEYSSKFLNGEINKMQYKGFSGGYGVYAQ
                     RDKKSFMIRLRVSAGVLSQYQLNKIYEIAIKHNLDKIHLTTRQAIQLHDLSINSIVDI
                     MEEGIKNDIFTRGGGGNYPRNVGLSPLSGVDPSEVFDVTPYAVATDKYFIKNATTYHL
                     PRKLKVSYSNCYTDTAHCSIQDLGFVATLKNDEPYFRVFLGGGLGKQPKVALELDELI
                     KPKDALYCVEGMIKFFMDYGNYENKNRARVRYMVESLGEELFLEKFKEYYKLEKENGS
                     LELNIEEIDYSKPGVKIDIQDSRLIPQKQDGLYTVYIHPVGGILLTKDLSTLLKELDN
                     VENPMIRLGMTEGLYILNLNGNEAKRILEISKTISCNSQLEQSISCIGVPICQMGIQN
                     SQKMLHEIIDYFRLQNNEEILNKAPKLYISGCLNSCGVHQVGSIGLCGKKKNVDGIST
                     DTFELFVGGSFEIGKTRLGKSLGDFKASDIPEMLYKISDASSGNFYEWVNSNDNILNK
                     ITDKYKI"
BASE COUNT        18916 a         4961 c         8418 g        14896 t
ORIGIN      
        1 aattaatgtc agtgtttata tagaatagca tttgtagcat ttattatagt tgtaattact
       61 atttatatca tagacttgaa tagtctaaaa aaatagacta taatattttt atagactaaa
      121 gaaagggctg ataagatgga catagcaaaa ctaattttaa atcctgcaag gcttcgtatt
      181 ttacaatata ttcgacttta tggcagtgtt cgtacatctg atattgtaaa gtatttaaat
      241 gatattcctc gtgcaacagt ttatcaccat gtaaaaattt tagaagagaa caatatgatt
      301 gaagtaatta aagaaaatcg tgtgcgtggt actattgaaa aggtttatgc actaaaggaa
      361 tatacaacat ctatggaagg agagaccttc gttgcacttt ctacagcatt ttatgtaggt
      421 ctgatgcagg aaatgaatga atactttagc agaaaagagc aagaccataa aaaggataat
      481 gtatttttct cttcagcatt actatatatg agtgataatg aatatgaaaa tcttcttaaa
      541 agtatagctg atttattgaa accatatata gaacaaaaac ctaaatcaaa tctaaaactt
      601 agaaaacttt caattatatc ttctccacct gtagctgata atgataaaac aaaataacat
      661 gcaacccatt tttataaaag gaggttatat atgaaatttc atgagtttgg aaataaaaac
      721 agaccacata ttatgttgat tcatggggga gggaatgcat ggtggaacta tttgcgacaa
      781 gcagaagttt tgtctaacaa atatcatgtg atacttccta cattggatgg tcatggagaa
      841 gaatatgaaa caacatacat ttctacagag gatacagcag ataagttgat atcatatata
      901 gatgaaaatt gcagtggaca tcttttcgct ttgtgtgggg tatcacttgg tggtcaaatt
      961 gtcatggaac ttttatctcg aaaacctaat attactaaaa aagcaattat tgatggtagt
     1021 atttgctacc caagacctct tatggcaagg ttttgtattg ctggtattcg attttttgga
     1081 ggacttttgt ttagtgagaa ggcttgtcgc tttcaaattg ctatgatgcc aaaattgtta
     1141 cctgaaaata tgcaatatcc agatgaaata aaagcgtatt atatgacaga tatgccacat
     1201 gtaagaaaag aaacattcta taatatgtat cgtacttaca tgatgaacta tacacttaaa
     1261 gagaatgtta aaaaaaccac agcacaagta atgtactggt atggagaaaa agaaatgaag
     1321 tgtgtcaaaa aatctgcaaa actgtttcag tcttatgtgc cctcttgtga gatttatgaa
     1381 gctaagagct ataatcatgg gtatttatca ctttatcttc caaatgaatg gttggaaatt
     1441 gcagaaccat ttttccaaaa ggaataaagg tgttaggtga ttattgtata attattgctg
     1501 tttttttata tagtaaataa attaggtata aatataaaaa attattttag ttaatatatt
     1561 agtgaaagct taataggaaa attataaata gattaaaggt agcacctata taaatagttg
     1621 ctaccttttt ctgtttgtaa ataaatgata gataagaagg tttactgaca aatcactgac
     1681 taaacccaat tttcttacat tgaaagcctt aattttactt gttttaaata aatttacaat
     1741 ttcttgttat aaaatactaa attttgttaa caattataat tagcatttaa tttatactgg
     1801 aggtttatat gattagtgta agaacagatt tagctttaga agctagtgaa atgtgtgaaa
     1861 agtctcaaga aggaagtagt attcctggtg taaaaataga aactaaagaa ttagaaaatt
     1921 gcattgtaac taaagttgaa gtaatagaca ggcaaggcgc agagataatg aataaagata
     1981 taggaaagta tataactctg gaaagtaatc ttatgaagtt tgatgatgat gagtcaagag
     2041 aagaaatgat aagttattta aaagaggagt tagtagatat atttggccaa gacaaaaata
     2101 aaaaaaccct ggtaattggt cttggaaata gaaatattac ttctgatgcg ttaggaccaa
     2161 agagtgtatc aaaaacactt gtaactagac atctttttaa aaattataat aaagactatg
     2221 atgatgattt cactgaggta tcagctttaa gcccaggagt tatgggtgtt actggaatag
     2281 aaactagtga aatagtaaaa tcattggttg agaaggttaa gccagataga gtagtagcaa
     2341 tagatgcatt ggcttcaaga aaaatggaga gagtaaactc tactatacag atatcaacag
     2401 caggaatatc acctggtgga ggtgttggca atactagaaa atctctaact aaagaaactt
     2461 taggcgtgga tgttattgca ataggcgttc caacggtggt tgatgcagca actcttacaa
     2521 tagatgtctt agatatggca atagacaatt taatagctca atcagaagaa acagaaagtt
     2581 tttatgaaat gttgaaaaaa cttaaagaag aagaaaaata tcatctaata aaagattcgt
     2641 tagacccata tgacaagaac ttaatagtaa caccaaagga tatagatgat acaatcgaaa
     2701 atctatctat aataataagt gaaggcttaa ataggtcttt acatccaggt agattggtat
     2761 aaaataagga ggagcaatta tgtttaaaaa atgcattaaa gtagtaacct tgacttttat
     2821 attagtatgc attttaccag gaaaatcatt agctttgaat caagatgatt ttttaaagtt
     2881 tttagtaaat tcatcttatc cagaagctaa agtcgaagga aatgatacag aaaataaaaa
     2941 gaataataaa aataaagaaa caagtaagga aaataaggaa gaaagtaaag aaggaaacac
     3001 taaatctaaa gatgcaagta aagttgataa taaaaaagag agtgaaaaag aatatataaa
     3061 actttatgtt ggtaaagaaa atgttccaga tattgagtca aaaaattcag acacaactga
     3121 aactaacaca acatctagtt cagattataa ggatgattta agagtaacca aagaaaatcc
     3181 aagaattttg atatatcata ctcatggatg tgagacttat tcaaattcac ctgatggaaa
     3241 ttatcattca agagataaga aaaattcagt aatggaagta ggaagtgcat taactagtgc
     3301 tttagatagc aaaggatggg gtgtagtcca tactactaaa taccatgact atccatctta
     3361 taataactct tatgcaagta gcttaaaaac aatacaaagt atattaccta aatataactc
     3421 agtggatata gcgatagact tacatagaga tgctagggat ttaactaatc cagccactaa
     3481 ggaaaaagac catttaaaat atacaactat gataaatgga gagagagtat caaagttctt
     3541 ctttgttgta ggaggtaaaa atacaaatag aaaacaactt agagctttag cagaagatat
     3601 aactgctttt gctgagaaaa agtatcctgg tctagtatct ccaatagtag aaaaagacta
     3661 tgctagattc aatcagtttg cagttaagaa tcatatgtta gtagaaatag ggaataacgc
     3721 aacaagtgta gaagaatcta aggctactac aaagtattta gccgagattt tggatgaata
     3781 ttttaaacaa aaaaattaga gctttaagtt ataattagga gcatgctaaa tgagccgatt
     3841 agaaaaaaat atagaaagta aaagtaaact aagaaaatac aagtatatta tgagaatctt
     3901 atttttgatt actatgatta tatgtacatc agtttgtgta tttatagtgg acagtaatgc
     3961 aaaaagtatg ctaggaatga aacaatatga ttttccaagt attaaatttg atataacaaa
     4021 atttgatttt gacataccaa attttgatat acatgaaatc ataaaaaaat ttaataagta
     4081 gtaataagtg aataaggttt attgattaaa ataagcctta ttttagttat atatttttaa
     4141 tgtataaaat aaaaattcat taactgtatt ttataggatt tactttaagt ttatgatatt
     4201 atataatatt tagtgttaga cttgataatc cacatataat gtggataatt ttgtttagtg
     4261 ccaattagtt tatattcaaa aattttaaat ttggtatata aagagttttt agataatgta
     4321 aaataataac tataagaata atcaagagga gggaatttta aggtggacaa taaacaaagt
     4381 agaactagaa attttagtat aattgcacat atagaccatg gaaagtctac cttagctgat
     4441 agattaatac aacaaactgg gcttgttagt gaaagagaca tgaaaagtca attacttgac
     4501 aatatggacc ttgaaagaga aagaggaatc actataaagc ttcaaaacat aagattaatg
     4561 tataaagcga aggatggaaa tgaatattat ttaaatctta tagatacacc tggacatgta
     4621 gactttaact atgaggtatc aagaagttta gctgcatgtg aaggagcact attagtagtt
     4681 gatgcagctc aaggtgttga ggcacaaact ttagccaatg tttatcttgc tatagaccaa
     4741 gatttagaaa tattaccaat aataaataaa atagatttac caagtgcaag accagaggaa
     4801 gtaaaaaatg aaatagaaga tttaataggg cttgattcaa gtgaagctcc tcttatttca
     4861 gctaaaactg gtttaaacat agaagatgtt ttagaagata ttgtaaaaaa tgttcctcca
     4921 cctaaaggag ataatgaagc tccattaaag gcattaatat ttgattctta ctatgatgct
     4981 tacaaaggtg ttgtagctta tgttagagta tttgaaggaa ctgttaaaaa gggtatgaca
     5041 ataaaaatga tgaataccaa taaaaagttt gaggtaactg aagttggtgt tatggctcca
     5101 ggtcaaactg aacttagtga attatcagca ggtgatgttg gttatattgc tgctagtata
     5161 aaagatataa gaagttgtcg tgttggtgat acaataacag attcaaataa tcctacagaa
     5221 gaacctttac caggatacaa aaaagctact ccaatggtat attgtggtat atatccagga
     5281 gaaggagaaa agtatgagaa tgttagagat gctcttgaaa agcttcaagt aaatgatgct
     5341 gcacttgaat atgaagctga gacttcagca gcactaggat ttggttttag atgtggtttc
     5401 ttaggtcttt tacatatgga gataatgcaa gaaagacttg agagagaatt taaccttgat
     5461 ataattacta cagctccatc tgttatatat agagttacaa aaatggatgg agaggttgta
     5521 atgatacaaa atcctgcaaa cttaccagaa ccatctgaga taaagatgat agaagagcct
     5581 atagtaaaag gagatataat agttcctaaa gactatgtgg gtgttgttat ggagctttgc
     5641 caggaaagac gtggaaatat gttaaatatg gaatatatag atgatagaag agtaatgctt
     5701 cactatgacc ttcctctcaa tgaagttgtt tacgatttct ttgatgcttt aaaatcaaga
     5761 actagaggtt atggttctct tgattatgag gttaaaggtt atgtagcatc tacacttgta
     5821 aaacttgata tattaatcaa taaagagcaa gtggatgcac ttagttttat tgtccatgag
     5881 acacgtgctt tccctagagg aaaggcaatg tgtgagaaat taaaaggaga aattccaaga
     5941 catcagtttg ctataccaat acaagctgct gttggtaata aggttattgc aagagaaaca
     6001 ataagcgctc taagaaaaga tgttcttgct aaatgttatg gtggagatat atctcgtaag
     6061 aagaaacttc ttgaaaaaca aaaagaaggt aagaagcgta tgagacaaat tggttctgtt
     6121 gaagttcctc aaaaagcatt tatgtctgtg cttaaattag atgagtaaat ccttataaat
     6181 ttagataaag atatttaaaa gctagagtga ttttagaatt atttctaaat tagtctagct
     6241 tttttatggt atattttaag taaactcata gagaatataa gtaagaatat taaagaagaa
     6301 taaaaaggtg atatttatga ttaatataga aattcctaaa aaagtagact atataattaa
     6361 agaattagaa aagaatggtt atgaagctta tatagttgga ggatgtgtta gagattgttt
     6421 attagaaaga gttccaaacg attgggatat aacaactagt gctagaccag aagtggtagt
     6481 agaattattt gaaaaaacaa ttccaactgg tatacaacat gggactgtaa cagttatgat
     6541 tgaacatgaa ccatttgaag tgacgactta tagaattgat ggaaattata gtgatggtag
     6601 acatccagat tcaatagaat ttacaaataa catagttaag gacttgtcaa gaagagattt
     6661 tactatcaat tcaattgcat acaattcaaa gacaggatta gtcgacccat ttaatggcta
     6721 tgaagatata caaaataagt atatacgttg tgttggaaat ccagtagata gatttgaaga
     6781 agatgcactt agaatgctta gagcagttag attttcagca caactcaatt ttaaaatagc
     6841 tgaaggtact aagcaaagta ttcataaaaa agcagatttg ataaaaaatg tttctattga
     6901 aagaatccag acagagttta ataaaatatt agtatctgat tcatctaaat taaacttatt
     6961 aaaatcaaca ggtttgttga aatttataat tcctgaaata tgtgaattag aagatgttac
     7021 tcaacacaat ccatatcaca tctatgatgt acaaaaacat actttaatag ctacagaagc
     7081 aattgaagat gaactgtatt taaaacttac aatgttgttt catgatttag gtaaaaaagt
     7141 aactaaaaca actgataaaa atggtgttga ccatttttat actcatagta gagaatctgt
     7201 aaagattgca aagaagattt tgaaaagact taagtatgat aattatacta ttaataaagt
     7261 tttaatatta atacaatatc atgattatag aatagaacct aaaaggaaga taattaaaaa
     7321 gttattaaat aaacttgaag atgttgaatt atttgaagat ttaataaaag ttaattgggc
     7381 tgatacactt gccaaaaatc caaagtatgc aaaacaaaag atattaaatc ttattgagtg
     7441 tgaaaaagaa tttaaacata taataaatca aaaggagtgc tttaatctta aagatttggc
     7501 tattaatgga aaagatttga tatctatagg tataaaacca ggtaaagata taggacatat
     7561 tttaaataag atgcttgaaa tagtcataaa taatccagag ttaaatgaaa aagaaatact
     7621 aaaagaaaaa gcattaaata tatatacatt ttagattcaa atataaaaaa tttaattact
     7681 ttaaaaaaca tagaataaaa tacttattta gataaaataa ataattttta gagaatattt
     7741 tagaagttac gattgtatga tttttaaatg cataggcatt tactctagga ctatagacta
     7801 atataaaaaa aaactttggg aatactaaaa ccataaattt ataaaattaa tattttatat
     7861 actgtaaaac agtgaggagg gacagtatgc atactcaact acaaaagact attggtcttt
     7921 cagcagctct ttctactgtt gtaggtatgg ttataggttc gggagttttt tttaagccac
     7981 aagcaatata cactacaact aatggagctc caggtctagg tattatagcg tggcttttag
     8041 gtggttttat aacaataact gctgggctta cagctacaga aatttcagct gctataccaa
     8101 aaactggtgg tatgatgatt tatatcgaag aaatatatgg agaaaagtta ggttttttaa
     8161 ctggatggat gcaaactgta ttatttttcc caggtacatc agcagcatta ggagtaatat
     8221 ttgctcaaca agcatctgaa cttttaggaa tgagcccaaa taatatggca aatgtacttc
     8281 ctatagcagt tggagttata ctatttttag cattattaaa tataataggt tcatccttag
     8341 gaggaaaagt tcagacagta gccactattg gaaagatgat acctttaatt ttaataatag
     8401 tctttggatt tattaaaggt caaagtagtg aagtattaaa tccatttgta ggagatggtg
     8461 taaatgcatc aaatgcactt ggacaagtat taatagctac tttgtttgca tatgatggtt
     8521 ggataaatgt tggagccata tcaggagaaa tgaagtctcc agagaaagat ttaccaagag
     8581 caatagttgg tggcttatca ttagttatgg cagtttatat tataataaat atagcttatc
     8641 tttgggtagt accagcaagt gaattagcaa cagttacttc cccagctaca ttagtagcaa
     8701 caagattgtt tggaaatata ggtggaaaag taataactgt gggtatatta atatcagtat
     8761 ttgggacatt gaatggatat ttattaacag gttcaaggat accttataca ttagctgaaa
     8821 tgggaacttt accagcatct aaaactcttt taaaagtaaa ttctggaggt tctcctgtaa
     8881 attcaatact acttataact gtgttagcct gtgtatatgc attatctggt caatttaatc
     8941 ttttgacaga cttaacaata ttttcaatat gggtatttta tgtattgact tttataggtg
     9001 ttatgaggct tagaagacaa aagccagatt tacacagacc atataaagtc cctttatatc
     9061 caataatacc aattatagct atattaggtg gactgtttgt aataataaat caaatattga
     9121 cttcaacagt catatcttta ggtgggatat ttataacact attaggttta ccagtttatt
     9181 attatatgaa aaaaagataa ctacttaatt taagttagat aaatttgggt aaaggtgaaa
     9241 attaactttt atccaaattt tttatactgt tatacaatat aagtattata tattacttga
     9301 tgtgctattt tgtttgattt ataatttagt aattgatgtt ttaagataat ttaagaaatg
     9361 aggagtgaaa gatgctagga ctttatgtac atattccatt ttgtgtgaaa aaatgtaagt
     9421 attgtgattt taattcttat aaaatggaca tagattcaaa aaaaagatat atagaagact
     9481 taaaaataga aatggaatta tatagtaata aattatataa agataataaa tataaaaata
     9541 aagaatgctg tagtctaaat aaaaatgaca aaataacgag tatatttgta gggggaggta
     9601 cacctagtat actaacctct gatgaaataa gagaagtatt tataagtata aaagaaatgt
     9661 ttgatataga tgagaatgca gaaataacta tagagtgtaa tcctgggaca ttaacattag
     9721 aaaaattaaa aactatgaaa gagattggca taaatagact tagtataggg ctacaagcta
     9781 ttcaagaaaa gcatttgaac tttataggaa gaatacatac ttatgaagaa tttgagaaaa
     9841 actataaaga tgcattaagt gtaggtttta aaaatattaa tatagattta atgtacagtc
     9901 ttccaaatca aactctatgt gattggaagg aaactcttga aaaagttgta cacttaaatc
     9961 caacacatat atcagcttat tcccttatac tagaagaagg aactgaacta tacaatatgt
    10021 atgaaagtaa taaatttgaa cttatagatg aaaatgtaga tatagaaatg tatgagtata
    10081 caataaacta cttaaagtca aaaggatata atcaatatga aatatcaaac tactcaaaag
    10141 aaggctataa ttgtgagcat aatattttat attgggaatg tgaacattat atagggattg
    10201 gagcaggagc ttctggctat attaatgaga acagatacaa taatgtagaa tctttagaag
    10261 attatcattt aagtttggta aaaagagaaa aaccaataca agaaaatgaa attctttctg
    10321 agaaagatat gatagaagaa aagatattta tggggcttag aatgaataaa ggcataaaat
    10381 ttgaagattt taaaaaaaaa tttggaatag attttagaga gaagtataat aagcaaatag
    10441 aaatgctatt agctagaaag cttataaatc agagctttga aggtatacaa ttaactcaaa
    10501 aaggaagaga aatatctaat agtgtattta tagaatttat ggaataattt ttaaggtgtt
    10561 gacaaaataa atttataatg gtatataata tatataatct ttttagcact cgaacttagt
    10621 gagtgctaac agctaggagg tataataata tggaattaaa tgaaagaaaa ttaaatatcc
    10681 tcaaagctat agttaaagat tatatagaaa cagctgaagc tataggttct agaacaatat
    10741 ctaaaagaca tgatttaggt gttagtgctg ctaccataag aaatgaaatg gctgaccttg
    10801 aagaattagg gtatttaatt cagcctcata cttctgcggg tagagttcca tctgaaaaag
    10861 gctataagtt atatgtaaac tctcttatga gtaaaagcga attggatgat aatgataaga
    10921 ttcttattga acaatgtatg aatcacaata taaatcatat aaaagaattg attcatgaaa
    10981 cttctaagct attatcgcaa ctaacaaact atacaactgt agcagttact aagagtttaa
    11041 taaatcaaag tgttataaag cacatacagt tggttgctat gaatgacaat aatattttac
    11101 ttatagttgt aacagataaa ggggacttaa aaaaagctaa ccttacaact aatgtatatt
    11161 tagatcaatc taagttaaat ttgatttctg ataatcttac aaggaagctc ttaggtaaaa
    11221 gtataacaga tttggatgat aatctaattg cttttattaa atacgaaata agtgagtatt
    11281 ctgggcttat agatgagctt ttaaatgctt tgaactcaaa tatgaaagaa gaagattttt
    11341 ctctatcatt aaatggagct actaacatat ttagttatcc agaatttaat gatgtattaa
    11401 aagcaaagtc atttttaaat atgttggaaa aaaaggaaac aatagctgac ataattaaat
    11461 caaagggaat acaaaaagac aatctaaata taataattgg tagtgataat gattgtgaac
    11521 tggcacagga ttgtagtata gttacagcaa cttataatgt agatagagac ttggttgggc
    11581 gaataagctt tataggccct accagaatgg attatgctag aatttactct ataataaatt
    11641 atatgagttt attaattaat agaaagtaaa gaaattttaa attgcgaggt gtaaagtctt
    11701 ggataaaaaa aatgagcaac aggaagtaag agaagaaaat gatacttcta ttaaccaaga
    11761 atcggaaact caagtagagt tagaagagga agttgttaat gaagaatgtg aaacatcaag
    11821 tgaaaaaact gatgaaaaag aagttgatga tgaaaatgta acagatataa attctaagtt
    11881 agcagaaaaa aaattgcagg atgagttgga tgaattaaat gataaatatc aaagacttca
    11941 agccgaatat gcaaactaca gaagaagaac tcaacaagag aaagagacaa taggcgtatt
    12001 tgcaaatgaa aaaataataa ctgaattgat accagttata gatagtatgg aaagagcctt
    12061 agatgcatgt gaagataagg aagatactat gtataagggt ataagccttg tacataaaca
    12121 attaatagac actttagtaa aatttggagt agaagaaata gaagcagaat ctaaggaatt
    12181 tgaccctaat ctacatctag cagttatgca agaaagtgta gatggagttg aagcaaatca
    12241 aatagtaatg gtacttcaaa aaggatataa gctaggaact aaagttgtaa gaccttcaat
    12301 ggttaaagtt tcttgctaag tataaattaa aggttaaatt atttaaccta atataaaata
    12361 ttaaaataag taaaacttaa ttatataatt actcgaggag gattttagtc atgggaaaaa
    12421 taataggaat agatttagga acaacaaatt catgtgttgc agtgttagaa ggtggagaag
    12481 cacaaataat agcaaatagt gaaggtatga gaactactcc atcagtagta gcatttacaa
    12541 aagatggtga aagaatagtt ggagaacctg caaaaagaca agcagttaca aatgcagata
    12601 aaacaataac ttctataaaa actcatatgg gaactgatta taaagtaaat atagatggaa
    12661 aatcatatac tccacaagaa atatcagcaa taatattaca aaaattaaaa tcagatgcag
    12721 aaagttactt aggacaaaca gtaacagaag cagttataac agtaccagct tactttacag
    12781 atgctcaaag acaagcaact aaagatgctg gtagaatagc agggcttgat gttaagagaa
    12841 taataaatga gccaacagca gcagctcttg cttatggtat ggataaatta gaccaagaaa
    12901 agaaaatatt agtatttgac ttaggtggag gaacttttga cgtatctata cttgaaatag
    12961 gagatggaac ttttgaagtt ttagctacag ctggtaacaa tagattaggt ggagatgact
    13021 ttgaccaaat agtaatagat tatttagcag aggaatttaa aaaagctgaa ggtgtagatt
    13081 taagaaatga taaaatggct cttcaaagat taaaagaagc agcagaaaag gctaagaaag
    13141 aattatcatc aacaatgagt tcaaacataa acttaccttt cataactgct acagcagaag
    13201 gaccaaaaca cttaaatata gatttatcaa gagctaaatt tgaagaatta actagaggtt
    13261 tagttgaaaa aactatggaa ccaactaaga cagctttaca agatgcagga ctttctacag
    13321 gtgatataga tgatgtatta ttagtaggtg gttctacaag aataccagca gtacaagaag
    13381 ctgttaagaa gtttatagga aaagaacctc ataaaggtat aaacccagat gagtgtgttg
    13441 cagcaggtgc ttctatacaa gctggagttt tagcagggga tgttaaagac ttattattac
    13501 tagatgttac tccattatct cttggtatag aaactatggg taatgtaatg actaagataa
    13561 tagaaagaaa tactacaata ccaactaaga agtctcaaat attctcaact gctgctgata
    13621 accaaacagc tgttgatata catgttcttc aaggtgaaag aagtatggct tatgacaata
    13681 caactttagg aagattccaa ttaacagata taccaccagc acaaagagga atacctcaaa
    13741 tagaagttac ttttgatata gatgcaaatg gtatagttaa tgtttcagct aaagatttag
    13801 gtacaggaaa agagcaaaaa ataactataa catcaaacac taatttatca gaagcagaaa
    13861 tagagcaaaa gataaaagaa gcagaaatga atgcagaagc tgacaaacaa aagaaagaaa
    13921 aaatagaagc attcaatcaa gctgaatcta ctatatatca aactgaaaaa actttaaatg
    13981 aacttggaga taaaataagt tcaggtgaaa aagaggatat agaaaaagct atagcagatt
    14041 taaaagctgt aaaagataat caagatgcta cagcagaaga acttaagaaa gctacagatg
    14101 aagtaatgac taagttccaa aaagtatctc aagaaatgta ccaaaaagca gctcaagaac
    14161 aacaagcggc acaaggtgca gaacaagcac aagacaatgg acctaaagat gacaatgtag
    14221 tagatgctga ctttaaagaa gtagatgaag ataaataagc tatataatat gtaacactaa
    14281 atgataattg gaacatatat gatttgtgaa aatcatatag atgttaaaga tatatggaca
    14341 atatacatca taaagaatat aatatatcat agattatata acttaaagta gaatataaga
    14401 attaatgata gcttgtagtt tattattcta caagctatcg ttttgtaaaa tgaaggtggt
    14461 gtcaattttt gagtacaaaa agggattatt atgaagtctt aggtatcagt aaaggtgcag
    14521 aagctcaaga gataaaaaaa gcttatagaa aattagcaat gaagtaccat ccagatagaa
    14581 atcctggaga taaagaggcg gaagaaaaat ttaaagagat aaatgaagct tatgaagttc
    14641 tatctgatga tacaaagaga aaaacttatg accagtttgg acatgatggg ctaaatggtc
    14701 aaggcggttt tggtggtcaa ggaggatttg gcggtcaagg ctttggtggt tttgaagata
    14761 tgttcggaga tatatttggt gacatgtttg gaggaagctt cggaggtgga agagcaagaa
    14821 gaagaggacc tcaacgtggt gcagatataa gacagagtgt tactatatct tttgaagaag
    14881 ctgcatttgg taaaaagatg tctataaaag taaatagaag tgaagagtgt gaagaatgta
    14941 atggaactgg agcaaaacca ggaacatcaa agaaaacttg ttcaacttgt aatggaactg
    15001 gtcaagttag aactgttcaa agaactccat ttggtaatat agcaagttca agaccatgta
    15061 gtgcttgtaa tggaactgga gaagtgattg aatctccatg tagtaaatgt catggaactg
    15121 gaaatacaag aaaagttaag actatagaag tagatatacc tgctggtata gatgatggtc
    15181 aaatgataaa actttctggt caaggtgaag taggagaaaa aggtgctcca agaggagacc
    15241 tatatattgt agttaatgtt aagtcacatc cactatttac tagagatgga aatgatattt
    15301 attttgaaat gccaattaca tttgttcaag caactttagg tgatgagata gaagtaccta
    15361 ctttggatgg aaaagttaaa tatagtgtgc cagaggggac acaaactgga actgtattta
    15421 gacttaaaga gaaaggaatc cctagaatta gaggtaattc aagaggagac caatatgtta
    15481 aggttgtagt tgaaattcct aaaaaattaa acgataagca aaaagaacta ttgagagaat
    15541 ttgcgaagga gtgtgggtcg aacgtccacg aaaagaagaa aaccttcgga caaaagatag
    15601 aagatatgtt taagaaaaag tagttaaagt agccaatata taatcatatt tttaaaatct
    15661 tagttattta taagattgtc aaaggagata ttatgatttt tatattggct atttttgtat
    15721 aaaaaataaa tgtgcataaa ataaaactga atataaataa ttttctgaaa aatacttgtc
    15781 ctaaaatata taatgtgcta taatataatc aaataaaaga aaggggtgat tccagtggga
    15841 acggatgtgg cactgccaaa tgatgaagaa aactttattg taatatacaa aataaaatta
    15901 gatactttta gtgctagatt aagtactgga aaaactcatg agctgggata attattgtaa
    15961 ttacctagac tcaaactttt agtagtaaaa tagtaatatt atatagacaa ggtatctaat
    16021 ttttaaatct tttgtatgaa ttaaaatttt tataaagggt atatctgatt agaatgtaat
    16081 tagggaaacc tagttgtgaa ttacttttag tatatacatg tgtaaagaaa tatgtatatg
    16141 gtattggtta ttgtgctaga tgtgtatgta aagaaatatg tgtctagttg ggtatatgta
    16201 aagaaatata cttataatct atgaaaaatt tttagtataa attgctaaaa cattgagatt
    16261 gttttttata gaaagttagt ttataccaac taaaaatgtg cttaagattt gtttgatgtt
    16321 taattataaa taaggttgta gataaaaaaa taagtaaaga caaaggttta aaatacttgc
    16381 tttaaatata gtttgttttg aacacttgcc aaattaaaat aattaataaa atagacatct
    16441 tctcatagta aaatatactg tgagaggatg tttttgcttt gttcataaac ttttatgaaa
    16501 aatttgcata gtgtcacatt ttaatatact atatatataa taaaatatag ataaaattaa
    16561 atgattcaaa agagaaaggt gaaaagagat gtattatata ggtgtagaca taggaggaac
    16621 aggtatacaa gcaggagtag ttgataacta tgggaaaata atttttaggt cagagtgtaa
    16681 aacagtaatt gaaaaaggat ttgaaggaat acttaatgac ataaaaataa tgatttataa
    16741 gttgttggaa gataataaac ttactatgag tgacataaaa tctattggat ttggtgttcc
    16801 aggttttata aataaagaag gattagtaac ttgtgtaaat ttaaaatgga ataaaaaagc
    16861 ttttaataaa gagttaaaaa gaagatttcc agatgttgaa attcatggag aaaatgatgc
    16921 aacagtagca gcacttggag aggcaaagtt tggaagtatg aaaggtgcta atgttggagt
    16981 attatatact ttaggaactg gtgtaggtgg aggaatagta attaatcaaa aagtcttttc
    17041 tggagcacat ggattgggtt cagaaatagg tcatcaaatt ataggagaaa actattttaa
    17101 ttgtaattgt ggaaataatg gttgtgtaga aactttttgt tcagcaactg caattataaa
    17161 gtattctcaa aaactgatag aagaaggaga aaagagtagg attttagatt tggcagaggg
    17221 aaatttagaa aatgtaaatg caaagatggt gtttgatgca tatagagaaa atgatttagt
    17281 ggcaattaaa gtaataaata gatttaaaga gtatttagca aaaacttttg caaacacaat
    17341 aaattcttta gacccagaaa ttatatctat aggaggaggc atttctaaat ctagcgatat
    17401 aatacttgat ggaatagaag atttggtaag aaaatttgta ttatacaaaa cagaagatat
    17461 agctacaatt acatgtgcaa ctttaggttc agacgcagga attataggag cagctttttt
    17521 ataatgtaaa tgaactgctt attggaggcg tgatgatata tgggtaaaac aaatgctaga
    17581 agaacgcttt ttttgatagc aataggttca ggaactatgc tgaatcctct taattcttct
    17641 atgatttcac ttgctttaca tagtatacaa aatgattttc atattagttt tacaactgta
    17701 tcttggattg tttcagcatt ttacctagct agtgctattg cacaaccagt ttcaggtaag
    17761 ataggagatt taataggtag aaaggtctta tttttgagtg gtttgatgct tgtaatttta
    17821 tcagcatcca tagtaccact tgttcaatca ttctttatat tgatttttat aagagtaatt
    17881 caagcaattg gaacaagtac cctatatcca tctggagttg ctcttataca aaataatata
    17941 aaagaaagac aatcttctgc attagcagtt ctaaccattt ttgcttcaac tacagcagga
    18001 ttaggtccga cacttggagg attattgttg gacttaggag gatggcatgc tatatttctt
    18061 gtaaatatac ctgttgtttt ggtttctata tgcttagggt attttttatt cccaaaagaa
    18121 gtaaaagaaa agaaatctat aaaagaaact ttaaaaaatg ttttgtcaag attagatatt
    18181 attggcatac ttctattttc aattgcaatg atttttatat tactattttt gctatctatg
    18241 aaggagtctt ttaacttaga acaacttata tttggtataa tactgatgtg tctttttatt
    18301 tggcatgaat tgagaacaaa attgccattt atagatatta agctttttgt aagtaatcct
    18361 aaattgtcaa aagtttactt gcaatttatt atattaaatt tctttaatta tattttgttt
    18421 tttggtcttc ctagttattt tcaagatgcc ttacattata gtgcaaagtc gactggatta
    18481 tttatgctat ttatgtctgg tataggtata tttatatctc cattaactgg aaaatggata
    18541 gataaatctg gaactagatt tcctcttgtt acatcatcaa tctttatgtt tattagtgca
    18601 gtacttcttt cagtagtttt tatccatata cctgtaatag gaaagggtat tatattatca
    18661 ttagcaggta ttagttatgg agttggtaat gtagccctgc aatcctctat gtttgaagaa
    18721 agtcctcgtg acagtatagg gacagcttct ggtttgtttc aaactagtcg ttatttaggt
    18781 tctattttag caactgtttt acttggaatg gtatttgaag taaatataac atcagaacaa
    18841 tttcagatat taggttatgt tatggtggtc ttaggtacaa taagtttttt attaaatttt
    18901 atattaaaga aagaattaag aaaagtagaa tagtggattt atggatttaa taagtctaat
    18961 aactgataag tttaaaaata ttgtttgtaa aacataactg gtttggtatt tattaattct
    19021 aagttttgaa gcatagagta ctcgataagt atacaatatt ttgaattaaa attaagcaga
    19081 aatttgaact agtctttcaa atctctgctt aatttagtag ttaaattttt ttatagagaa
    19141 aataagattt gacacttaga taaaaaatca ttgcattttc aaaattcttt aaatcaaacc
    19201 caagtatctc attaatcttt tccaatctat atactagcgt gtttctatgt aaaaacatac
    19261 tagtagatgt cttagaaata tttaaatcat tatttataaa ttttattcct gtatatagaa
    19321 gttcttcgtc aatagattta atcttattaa aatctattaa tttattgagt atattatcct
    19381 cattaattaa atctaaagtt ttatatctaa taaggtcaaa caaatttaaa aacttatttt
    19441 cagcgttgtc ttttataata tgaggtagta aatcagaaca taactgtaat ctaaaatcaa
    19501 aatcagcttt actatctaat ttaccaagat aaaaaatata agtactttga taagtttcag
    19561 tttcaattat attttgtgta gttacattaa tatctaagtt atatttagaa tttactataa
    19621 aaaaaccatt gtgttgtatt atatttatat cttcaaataa attataaaaa atatttttta
    19681 gatattcaaa gtctatatga gattggtaaa ttaaataaaa gttgcctttt aaattatcga
    19741 gattattttt atctagaaaa tcaataacat aaatagcatt attgaaagta actaaatggc
    19801 tactagcatc taacttttgg ttttcatatg gatagatatt tattttttta ttaagctgtc
    19861 tttctaaaaa atcttttaac tcttccataa agtctcctta aaaataagat tatattctta
    19921 tcttatagct aaagtagttt ctttgtcaaa tatgtgtact ctactattgt caactgaaag
    19981 tgttaagtca tcaccaacat taattctgtt tttactgtca aatctaattg ttatcgtatt
    20041 ttcgcctagt tttaagtgag cataagtttc tgctcccata agttctttta tttcaattct
    20101 tgatttaaaa caagtatctg gattagattt aataaaagta tcttctacat gaatatcttc
    20161 tggtctgata cctataacaa cttcattatt aatataattg tcttttatta aatcatagtg
    20221 tttttcttta ttcaatttaa gcttaatatg ttcattttgt gcataaattt catcattttc
    20281 ttctattaat attacatcaa taaaattcat ctgtggtgct ccaataaatc ctgcaacaaa
    20341 tatattagct ggataatcgt atacatcttg tggagttgca atctgctgaa ctactccatc
    20401 cttcattact acgattctat cagccatagt catagcttca acttggtcgt gtgttacata
    20461 gataaatgta gttccaagct gttggtgtag cttagttatc tctgttctca tagcagttct
    20521 aagttttgca tctaagttgg atagaggttc atccattaag aataccttag gatttctaac
    20581 tattgcacgt cctaaggcaa ccctttgtct ttgtcctcca gataatgttt taggtttttt
    20641 atttaaaaga ggtagtaaat ctaatatttt agcagcttct ttaacttttt tgtctatttc
    20701 atctttgggt aattttctaa gtttaagtgc aaatgccata ttttcgtaaa cagataaatg
    20761 gggatataaa gcatagtttt gaaaaaccat agctatatct ctatcttttg gttctatatc
    20821 attgacaagt ttatctccaa tgtatagttc tccttcagag atttcttcaa gaccagcaat
    20881 cattctaagt gtagtcgatt taccacaacc agatggtcct actaaaacga taaattcttt
    20941 atctttaatg tctatattta tattttttac tgcgttaaat ccatttgagt aaagttttga
    21001 tatatttttt aaaattactt ctgacataat atcctccttg atatttaaat tttaattata
    21061 tagtatcaaa tttttttgtt atattaaatg tgtaaaatga ctaaatgtat ttgtttaata
    21121 tgtatattta gtttttagca aagaataaaa ctaacagtaa agtatattta aaaaattaaa
    21181 aaacaaaatt aaatttatta tcaaaaaatc attttatgat atgttttatt tttatattac
    21241 aaatagagaa taatgaatta tactagaaag taggaggtga aaatatgagc agaatttcaa
    21301 tttttatgga atcatgtaat ggcaaatttc caaatgaaaa ttcaatgttg tcagtttcct
    21361 ttataaaaaa tattttaaat gcagaaaaca aagattttgc taaaaacata tttaactatg
    21421 ggaaagaaag aaaaaacaat aagcaaataa aggatataaa tacagccatt tacataccaa
    21481 atcttataag aagcaaaaat gagttacttg ttgatggaga tataatattc aatataagtt
    21541 tttataatta ttctatgttc agtaaattat acaatggaat tttaaaagta aaggagctag
    21601 aatataaagg ttatagattt aaaataaaaa atataaaaat acataaagaa cacgagataa
    21661 aagaaaatgg tgttatattt aaaactatgt ctcctataat agtaaagaat aaagaaggta
    21721 aatatttaga tgtagaagat tcaaattata tagaatgttt aaactatata gctaatctaa
    21781 ctctggagag tataagaggt agtgggctta gaaagccatt ggaatttata cctcttaact
    21841 tcaaaaaaag agtgttaaaa gaaaagattc gtggatttaa agtgagagaa ttttactata
    21901 taaatgctta tgcaggaaca ttttttttaa aaggagatat ggaagattta aatgcactgt
    21961 ataaaatggg aattggatat agaaggacgg aaaatgcagg aatggttgat atattaaagt
    22021 agcgaggtga gagaaataaa agctaaattt tatagatcag gtgatattgt aagagatatt
    22081 ggcattgttt acttttatga attactaatg gatttaaaaa acgaactaga aaaaaatgat
    22141 tataagctaa aatttacttg tgagttaaat agaaattatt tatctttaga atctgcagaa
    22201 tatatagacc ctaagtatat atctgattat atattagaaa atcaactttt taaggtattt
    22261 aaaaatggga aaaaggaaac cttagaaaaa atatttagta atatagataa tttaacgtat
    22321 gtaaatttta ttgaagaatt ggataaatct tctgcaactg ctaaacaaaa ggaagatatt
    22381 aaaaaagatt ttaaaaacag gaggtttcca tatgttagaa atagtggtaa gtatggatta
    22441 aacacgagtt tagaaaatat ggaaacaaat gtaaaaagaa tagtagatac tgtaattaaa
    22501 tcaaatatag agatagatga aatagataaa cttgatttga cacaatatga agaaaaagat
    22561 agtgtatgta atgtttgcaa tataaataaa acaacaaaac tagatattga tttaagagaa
    22621 cgaaaggact ctaagtataa ctttttattt agaggtgcag aaaaatcagg ctttaaaaga
    22681 agtggacaag ttgaaagtaa tatttgtttt gagtgtgaat ttttcaactt aatgtgtctt
    22741 ttatatataa atttaaaaag accaatggtt tttgcatata cgaatgattt aagagaatta
    22801 gcatttttaa atcataagat aatgcttaaa agaaaaatgt attcagataa atcattttat
    22861 aaaaaacttt tgcatgaaaa aataagttca attagactat atagatttga tattgttaag
    22921 aataaaggta taattctaaa gtttgactct attatagagt ataaagaatt attaaaaaaa
    22981 attgaactta tagatattat agataattat aatttctcaa gggagccagt aaacactaaa
    23041 aatttaggta aaaaaatgat tgataatgga aatttatcaa atttaaaaga attattactt
    23101 gataatataa gttttttaaa gcaatcaact ggaacttctc gagaaatgga ttttgtatct
    23161 agctcatata atatcggttt atatataaaa ttgtgttgga ttgtagatgg aggggaggag
    23221 tataaaatga aaaactatat ggaaagtaat ttaatatatt caagagtagg taaagactta
    23281 tttaataaaa tgacagatga atccagaaga aaaaattttt ctatgaaagt gattcaacta
    23341 cttaagtcta atgatagaac tcagctattt caaactataa tgcatgtgtt agtttctaat
    23401 ggaatcttaa taggagaagg gtttgtagaa ggtctaatgc agagttctga attagaatta
    23461 aatacgaatg taggtctatt tattcaagaa atcatgaaat aaaaaagggg gaaaatttaa
    23521 aatgaatgaa aaaagagtaa aaggagtaac attaactata ctgacagaaa gcccagttcc
    23581 actttcatat gaccaagggt atggaaatta tacaccaata aaaaaagaac aatatagaga
    23641 aaaaatacat gcaaaaacta gtatagccac aataacatat gatttaagaa gaatgctcca
    23701 ccaagaatat ggttggaatt taagtaatat tgtttttgga aaaaaaggaa atatatatcc
    23761 atctattaag aaaaatgtag gatgtgtaga tgaaaatgga ttagagactg atgtatttgg
    23821 ttatttgata ccacttaaag ataaaggttc tataagtaaa gcttctccac ttagaataat
    23881 accttttagg tcattaaatc catatatagg ttcaacacag ctaataacaa atagaggttt
    23941 tttaagtagc gaatttggta gaaaatatta tgatgagaag gaagaaaatg aagtacctag
    24001 agatgaaaac tttccaacaa cacaagcatt agcaatagaa gagactttat cagattacta
    24061 cgtttataca ataacattgg agcttgatag aataggagta gtagaagtag aagatgggaa
    24121 gttactttta ccagaagaaa gaaaatttat gagtaaggaa ttaagagaaa aggcagtaaa
    24181 agatatatta gatgcaatta ctgtgtttac aagaaacata aaacattcat cagtactatt
    24241 aaaaccactt gcagtaatag gtggagcttt tgataaagtt gtaccatttt tttgggatga
    24301 tgtagattat aacgctgata gtggtgagat aaatttagag ggagtcatag aaactataga
    24361 aagttatagc cttaaagaaa gtaacacaat acttgctatc aatgacagat taaaaatttc
    24421 taataaaaag gaattaaata agtttaattt aagtaaatac cctgtaaaag agattaaaaa
    24481 tctagcagat agattggaaa ttggagaaga taatatgtgg tatttaaaag agtaggaggt
    24541 tttttgaatt atgaaagtat tacaatgtaa acttaagcaa ccaactgctc actatagaga
    24601 cccaaaagta tttcaaaatg aatatataag tactttaaat ttaccatcta agaccacaat
    24661 aatgggaatg ataacgtatt tatgtgatag aagattaaac tctgatatag atataggaat
    24721 aattggaaca catcatcata gagaactaga attttcaaga ggagagaaca ttgatttttg
    24781 gaatgaatat acaaatatga gaaaaggcaa agataaagaa aagtttttgc ttcaaggaaa
    24841 ctactatgat tattataaag aacataaagc tcaaaatagc atattaaact atgaagttct
    24901 taaagaagta gaactgacta tatttatttc ttgcaaggat gatgaagaac ttgaatttat
    24961 taaaaaaaag cttgaaagtc catgtaaata tgcaaattta ggaagaaaag aagattttgt
    25021 aataccaagt gaaaaagggt gttttgtgaa agaagttgag ttaaaagagg ttatacctat
    25081 gaatactcgt gatgctataa aagaaaatat aaaattaaag aatacatatg taagagttga
    25141 cttaagagat aaagagaatg tcgagactat aataaatcaa ggtgtattga ttgcattacc
    25201 tcataaatat aaagatttag aagcaaatag agatgataga gtttatgagt tttgtcatta
    25261 tatatatgtt gataatgatg gtatatatcc taaaaatatt aaggtaaatg tatgtattga
    25321 tacaaaagaa gtttttacat ggctttaaat tattttgaaa gataggtgtt tatcatgaaa
    25381 aatatcatgc aaaaagaaat attagctaag tcatacaatt taagaactaa tcaacaagag
    25441 caaacattag ttgaacatat taaggattta tttgaagtat tagaatctat attagaacta
    25501 aatctatatt cagataaaga tgtagagata ttgaaaatat gttgtgcttt gcacgattta
    25561 ggaaaaatta attcaattat gcaacaaaaa atggagatta ataataaaat atcgtatagt
    25621 tgctcagaag aagagaggaa aaagttagag tctgacaaaa aatctttaaa aaagatagca
    25681 agacataata tattttctgg agcattttta aaagatatat tagaaaaaat gaacttgtca
    25741 gaagaagata agttatatat atataaaagt ataatgttac atcatggaaa ctatgaagat
    25801 tatatgaggt taagtattag taaagttcaa gaagaaattt atgagtatat tgaaaaaggc
    25861 attttagaaa aagaagagtt taatctgaaa gatatagaaa gttatataaa taacatttta
    25921 aatgtagact ttaaatttgg tgaagatgta ttggattatg attacataga taaattaagt
    25981 gaaagtatgt ttatagacag tgattataac aatggtcaaa tagatgattc agttttaaat
    26041 tatagaaagt ttaagtatat tttatataaa gggatgctga acttaataga ccatagtgca
    26101 tcaagtagac agaaaggtat aaaattttat aacgatttta ctgatgaaga aattgataat
    26161 atgattttaa atgagatata taagagtcag ggtaatttag aaaaaaataa tatagagttc
    26221 aatactatac aaaaaaggtt gagagaactt tctggaagaa atgttctgac tgttgcattt
    26281 acaggttcag gaaaaacagc tgcagattat agaaagactt ttaaaagaaa attcttttta
    26341 gtgccaaata aaatatcagc agaaagtttt tatagaaaaa atatttttca aaataaaaat
    26401 gatttagata caagaagtag taatgattac attggattac ttcatggaga tataaactta
    26461 tattcagaga atgaagataa tggagaacat gattttgtat tgacattaag ggatatagat
    26521 ttgagtataa acttttgtaa accttgtgta attgcaacag ttgaccagtt attacttagt
    26581 atgtttaaat ttccgggata tgaaaaaata ttcgcagccg taaaaaatgc atctataact
    26641 gttgatgaag tacatttatt ggaaccaaag atgtttttga ttttgatata ttttatgcag
    26701 tttgcatgca agtacttaga tgttgatttt cacttaatga cagctacact tccaaaatca
    26761 tataaagagc aaatgataaa caagggaatt atttttcaag aagaaagtaa taaaaatgtt
    26821 actgataaag gagaaatagt ttttattgag agcaacaagg aagaagagat ttgtgaaggt
    26881 aaagatgtaa aggtttcttt tataaaggaa aaagaaatca agtcaatagt tgaagatgct
    26941 ttagaaaata aacaaaaaat tcttataata aagaatacta ttgattcagt caatagaaca
    27001 tatgagtttt taaaagaaaa tttatctgat aagtatggtg gtgtagatat agatgtttta
    27061 catagtagat ttaagttcaa agataaaaaa gagaaatata gtaaaatatt aaatggagag
    27121 ggtgatattt ggatatcaac tcaatcagta gaaatatcct tggatttgga tttcaatata
    27181 ataataagtg atttagcaac tatggatagc ttgatacaaa gaatgggtag atgcaataga
    27241 aataataaat atgaatatgg aaacttttat attctaccta gtgaagataa aatttatgat
    27301 aacaaactta agaacacaac taaaaacatc ttaaaggaca tattaaaaac taactctatt
    27361 tttacaatgg gaattagaaa aactattttg gatgattact atgataatag tgtagtcaaa
    27421 aaatattttg aagagaattt tataagttgt gataaagaaa ttaagaatat ttatggtata
    27481 aataaagaaa tttttgatgg attagattta atttttaatt ttgaacctta caaaaatatt
    27541 gttgatagta agaaggaagc agctaaaatt tttagagata ttgatgttag ttacaaaatt
    27601 attctggaag aagattttta taaggaagat agggagttac aacaagattc gattcaagta
    27661 tcagggttta tatttaatag attatattat tatggattaa taagtaaagt agaaggatac
    27721 atggtactaa aatctagtag taagtttgag tataatagta ctgtaggctt aattttgaag
    27781 tgagcatatg tttaaatata atataccttt agccattgaa aatacaaaaa gtactactgt
    27841 aagtccactg taaaaactat tttttaaaag gaaaaataag ttgtgagata gagtgtttac
    27901 aagtgtatat agataataaa tttgaggttt aagattaact aagtgggttt caggtacatc
    27961 gcgaaaataa ttataagttg gagattttgt atgtttaaga ttaactaagt ggatttcaaa
    28021 tattgatata gtagatataa tagaagtttt attattaggt ttaaaattaa ctaatcggat
    28081 ttttaaatat tctgactatt atataaggat attattagct tgaatttaaa accaataata
    28141 taaaacaaca aaatattata tttatgatat aataaaagtt atggaaaaac aggaatatta
    28201 ctatagagaa gagaggtaaa cttatgaata attggataga agtaactata aaaacaacaa
    28261 cagaagcagt tgaacctata acgaatatac tatatgaaca aggagctgga ggagctgtaa
    28321 tagaagaccc aaaagacttt ttattccaaa agaaaaatga actagactgg gattatgttg
    28381 aagaagaagt atttaaaaag aatgaagaag atgatgttct tataaaaact tatgtttctg
    28441 aagaaaaaaa tgtgatggaa tttgtcgaaa taataaagca aaaagtttta ggattaaaag
    28501 attttggtat agatataggt gaaggaagtg tatcattgga ccaagtaaat gaagctgatt
    28561 gggcaaatgc atggaaagca tactacaaac caacaaaagt aggacaaagg gtagtagtaa
    28621 aacctacatg ggaagattat gctatgcaag agggggattt aatcatagag cttgacccag
    28681 gaatggcatt tggtacaggg acacatgaga ctactagtat gtgcattaga gaattagaaa
    28741 agtatgtgaa taaagattct aaagtatttg atattggctg tggtagtgga atccttgcaa
    28801 tagcagcagc taaattagga gcaaaagaag ttgtagctgt agatttagat gaagtggctg
    28861 taaaagttgc aaaagaaaat gttcttgaaa ataaagttga aaaaagtgta tctgtaatgc
    28921 atggtaattt aactgatgta ataaaagata aagcggatgt aatagttgca aatataatag
    28981 ctgatataat aaagatactt gcaaaagatg ttcaaaactt tatgaaagaa gatgctatat
    29041 tcatatcttc aggtataatt ttggataaag tagaagaagt taaagaaagc ttaattgaaa
    29101 atggatttga aatagttgaa gttcaaaaat taggtgaatg gtcagcaata gtttctaagc
    29161 ttaaaaaata agggatatgg tgacgtataa tggatagatt ttttgttgaa aaaaataata
    29221 taaatctaca agataaaact tgcactatag aaggtgaaga tgtaaaacat atttcaaaag
    29281 ttttaagatg caaattaggt gagaaacttg aaatatgtga caagaataat aatgagtata
    29341 tttgtgagat aatgaatata gataagagta tagttaattt agaaatttta gaaaaagttg
    29401 atataaatag agaatcagaa cttaaagtaa ggctatacca gggacttcca aaagctccaa
    29461 aaatggaaat gatacttcaa aaattaactg aagtgggtgt agaagaaata atattagttc
    29521 aaactaagag aagtgttgtt aaagttgatg acaaaaaaga agataaaaaa tttgaacgtt
    29581 gggaaagaat aatttatgaa gcagcaaagc aaagcaaaag aggtaagata ccaaaattaa
    29641 gaggtgtttt aagttttaaa gaagctttag aagatatgaa aaaaaataat gtaaatattt
    29701 gcccttatga aaatgaaaga acagtttcaa taaaacatgc actaaaaaaa tgtgattcta
    29761 atatagatag tgttggaatt tttataggtc cagaaggtgg attttctgaa gaagaaatag
    29821 aacaaataca aaaaaataat tgtaatgttg tatcattggg gcctagaata ttaagaactg
    29881 agacagcttc tgttgtagca tcaacaatag ctttgtatga actaagtgat ttaggaggag
    29941 aaaaataaat tgaaaaaagt agctttttat acacttgggt gtaaagttaa tcaatatgaa
    30001 acagaagcta tgctagaact atttgagaaa gatggttatg aacaagtcaa tagtgaagag
    30061 tatgctgatg tttatgttat aaatacatgt acagttactc atatgagtga tagaaaatct
    30121 cgtcaatata taagacgagt taaaaagaag aatccagatg caataatagc cgttgtagga
    30181 tgttattctc aggtatctcc ggaagaaatt ttggatatag aagaagtaaa tttagtcatg
    30241 ggtacaaatg atagaagaaa gattgttgaa gaaattaaaa agataaattc aagtaagaaa
    30301 gttagtacag ttgacgacat aatgaaagtt aaagcttttg aagaaataga aatcagccaa
    30361 actaatggaa agactagagc atttatgaaa atacaagatg gatgtgacag attttgtact
    30421 tattgtatca ttccttatgc ccgaggacgc gttagaagta gagatattga tagtatagtc
    30481 gatgaagtga aaaaattggc taataatggc tataaagagg ttgtattaac aggaatacat
    30541 gttgcctctt atggaaaaga tttaaaggat agggatatta aacttcttga tgtaataaaa
    30601 caaataaacc agatagaaaa aatagaaaga attaggctta gttctgttga accaatttta
    30661 tttacagatg aatttgtaaa tgaagtttta aagatggata aagtttgtcc tcattaccat
    30721 ttatcacttc aaagtggatg tgatgaaact ctaaaaagaa tgaatagacg atacacaact
    30781 ttagagtaca aaactattgt agatagattg agaagtaaaa tgccagatgt ggcaataact
    30841 acagatgtaa tagtaggttt tcctggagag acaaatgaag agtttaaaaa aacgtacgag
    30901 tttttaaaag aaatagagct ttcacaaatg catattttta aatattcacc aagaaaagga
    30961 actccagctg caactatgga aaatcaagtt gaccctcaaa tgaaacactt tagaagtgaa
    31021 caacttttaa atttaagtaa agtaaatttt aataaatttg caactaaatt tatcggccgt
    31081 gagttggatg ttttgtttga acaaaatata gaaggcaata aatatgaggg attaacttca
    31141 aattatataa gagttgttgt tgaaagtgac aaaaatatac aaggtcagat attaaaagtg
    31201 aaaataaatg atgtaaaaga tgaatatgta gaaggaattt tgctataaca tgtagaaatt
    31261 ataatattta taagatagga ggtggaaaga atggattgta ttttttgtaa aatagcgaac
    31321 ggagaaatac cttcaactaa agtttatgaa gatgatagag tcttagcttt taatgacttg
    31381 aacccagttg ctccatatca tatattagtt gtacctaaaa aacattatga tagtttaatt
    31441 gatattcctg ataaagagat ggacattgtg tcacatattc atgttgttat taataaaata
    31501 gctaaagaga aaggttttga ccaaactgga ttcagagtca taaataattg tggaagtgat
    31561 ggagggcaag aagttaaaca tttgcactat catattttag ctggtaaaaa gcttcctaat
    31621 tacgaagcgg gacaaaacta aactaaatta ttgaaaaatt gagttccttc ttgataaaaa
    31681 tacttgataa aagtaaaaat ttagtttata ataaacaaag tgttaggttg taatgcatat
    31741 tatgcaaaaa gaacatagtt acagtcccag cataattgcg ctattggagg gagggaaaaa
    31801 gaaatgtcag aagtaagagt tagagagaat gaaacattag acagcgcttt aagaagattc
    31861 aagcgtcaat gtgcaatgtc tggcatcatg tcagaagtga gaaaaagaga gcactatgat
    31921 aagccaagcg ttaagcgtaa gaaaaaagct gaagcagcaa gaagaaaaaa cgctaagaaa
    31981 tagtagtaaa taagaataaa gaggtgaagg ggatgtccct taagcaaaag ttacaagagg
    32041 atttgaaatc ttcgatgaaa aacaaagata cagtgagaaa atctgtagta actttaataa
    32101 gagcttctat aaagcagtat gaggttgata atagggtcga gcttgatgaa gatggaatta
    32161 tcgatgtaat agcaaaacaa ttaaagcaac gtagagatgc attagttgaa tttgaaaaag
    32221 ctggaagaga agacttaata aaagaaacag aaggtgaaat tgaagtttta aaagagtacc
    32281 tacctcaaca attaagcgaa gaagagttag aagaaattgt aaaatctact atatctgaag
    32341 taggggcaac ttctatgaag gatatgggaa aaataatgtc agttatccaa ccaaaagtta
    32401 aaggaagagc tgacggaaaa cttataaata agttggtaaa acaaaactta caatagattg
    32461 atatagccta gagagaaatc tctaggcttt ttatagtttt tgggaataac gagtcatatt
    32521 tgagcatatc tataatcaaa gaaaattttg aaagaagggg aaaaatttga ttatatcagt
    32581 aaaagagatt aggaattttt tgataaacat atttatacca ctaataatag gttacttaag
    32641 tagcatctta acaatgatta tcagtggaac agatatttca acctattatt tacaactcac
    32701 aaagccaagc tttgcaccac cagcttttat ctttcctata gtttggacta tattgtacat
    32761 attgatgggt atatcttcat acctaatatt aagaaaaggt tacaacttac ctaaagtaag
    32821 agatgcaatt ttttattatg gattacaact tgtattaaac tttatttgga gtatactatt
    32881 ttttggattt ggacttagat ttacagcttt gatagatata ataataatga ttttggtttc
    32941 tataataatg atttcgaagt tttctaaaat agataagaga tctggataca taaatttgat
    33001 ttatttaatg tggcttgttt atgcaggatt tttgaactat tttatatggt ttattaataa
    33061 atagaatgta aagattttgt aaattaccct gtacttttaa taatatcata acaaacgaaa
    33121 aataaataga ctattaaaaa taatcatttt catatacaat aatattaatt taaatacaat
    33181 aaatttataa aaattgtatt taaagattaa catattaaag tattagaatt ggaaaggctt
    33241 gaagggagag gtttttatgc aaataatagt atctgggaga caaatgaaat taactgacgg
    33301 aataaaagga tacgtagatg gaaaattaag taggttagaa aaataccttg atcctgaatc
    33361 agaagtgaaa gtaacagtaa gtgcgaaaaa ggatagacaa aaagtggagg ttacaataat
    33421 tcctattaac ggtcaaataa taagagcaga agatgtagaa gatgacttat atgcagcaat
    33481 tgatattgtt tgtgacaaat taagtagaca agttgtcaaa tataaaacta aagttaaaga
    33541 caaagttcaa aataataaga gcataagatt tgaaaatctt gactttatag ataatagcag
    33601 tgaatttgat gattatgatt atgatgatga agaagatgaa aatatagtaa tagaaagaag
    33661 aaagaaattt aatgtaaaac ctatgagttc tgaggaggcg atacttcaaa tggaactagt
    33721 aggacacaat ttctatatgt ttagaaacca agataatttt gaaataaaca tagtgtataa
    33781 gcgtaaagct ggtggatatg gtttaataga acaagattaa taaaaattgt atacgtttag
    33841 attttatata agaaaaaata aaaaggtaat catgttgatt ttttatcaat atgattacct
    33901 ttttcttgtt taaataatat attagatatt aggtatttat tatataaaaa ttttaaaact
    33961 aatctgttac aacatcaata aagtgcataa atacctattt caagcataaa attaattaag
    34021 ggggtaatgc ttatgttaga aatatccact gatttacaag taaatcaacc agttattact
    34081 gttacaagta atacgtttat tagtatagaa aattatctat caatattaga atatgaagtt
    34141 gatttaataa gaataaagac taaagttaaa acaattaaaa tatctgggga taaactttca
    34201 cttaagtata ttactgatag tgagataggt ataaaaggga ttatctacaa tgttgagtat
    34261 gttgattagg aggagataca cttgataagt tttataaggg gatactatgt tatagttgtg
    34321 gaaggagtag gactcgaaca atttttaaat catcttataa gaaatgggat aagtgtttac
    34381 aatgtaacta gaataaaaaa tactaaaatg gagtttcata tagatagaca agatataaaa
    34441 gactttaaga atgtttatag aggaagtaag tttgatataa aggtaaagca aaaaactggg
    34501 gtccctttta ttatcaaaag agtttataag cacaaaggta tgtggatttg tgctcttgtt
    34561 tctttatttt tattgatgtc tacatcacag tttgtgacag atgtatatat acaatctcct
    34621 gaaggtataa aaaaagaagc tcttagaaat gagctttata aggttggagt aagaccagga
    34681 gtctataaga agagtattga tagaaaagaa gttagagacc atatgatgtc aaaatttaat
    34741 gatgtggcat atttatctat caatgtaaaa ggaacaaata tatttgttac tgttacaaaa
    34801 aaggcagaat ccctaaaatc tacagaccaa tcaaattatt gtaatgtaat tgctttaaaa
    34861 aatggtataa tagaaaaggt aatccctaga agtggtaaat cagttattaa atctggagac
    34921 atagtccaaa agggagatgt cttattaaat ggagctaata ccaagtcaat accagaagta
    34981 tgggcaagta ctttttatga gtccacaaaa aaggcaagtt atgtagatac tgtaaataaa
    35041 aaaactggag aaaagaaaaa tatatataca ctaagttttt atgataaaga gtttacaatg
    35101 agaaaaaata taaaatataa agattatgtt gttgaaaata aagaaaaaaa actatcaata
    35161 ggaaactata cttttccaat aaagataaaa acgagtactt tttatgaaac aaaaaaggtt
    35221 gaagtaaaaa ggaataaaga agagttaaaa aaagaattat ctgaaaaagc tttaaaagag
    35281 ttagaataca taatcccagc ttcggctaga ataatagatg taaaacataa ctttaaggtt
    35341 aataaaaata tgttagaata tttaataaca gttcaaacta gtgaaaatat tgctaaaatt
    35401 tatcctctta gtaagtcaga agcagaaagg tttataaagg aagaaagtaa accagatgaa
    35461 ggtgaagagg aagttccttc caatccagaa aaaagaccat taaatgatat aagaaatgag
    35521 tttgatgagg ataataagga taataaagat caaaacaatt ctgatgaaaa taatagtaat
    35581 caaaatagta ataatagtca aaataataat agcaataaca actaataaaa ttaaacttaa
    35641 aatcttagga ggactaattc aattgataat acaaaagaaa tttacaatag cagatggtaa
    35701 ctttgaaaga gagttatttg gcaactttga tgaaaatgta aaattaatag agaagacttt
    35761 aaatatagat gtaatactta gagaaggcaa tataatttta attggagaag aaaaaaatgt
    35821 agattctgca ttaaaactta tgaatgaatt acaccaaact gtatcaaatg gtaagcattt
    35881 agataagcag agtatttctt attcattatc tcttttgctt gaaggaagtg aacaaaaaat
    35941 aaaagaactt gaggggacaa tcgtcataac tcaaagggga aaagctgttc aacctaaaac
    36001 tttaggtcaa aaagaatata taaaacttat agaaaataat gatataactt ttggtgttgg
    36061 acctgctgga acaggaaaga cttatcttgc ggttgctatg gcagtaaaag cttttaaaag
    36121 agatgaagtt agtagaatta tacttacaag accagctgtg gaagcaggag agagtctagg
    36181 ttttttacca ggagatttaa aggacaaagt tgacccatat ttaagaccac tatatgatgc
    36241 cttatttgaa atgttgggtg ctgataaatt taataagtat ttagaaagag gtactattga
    36301 ggttgcacca cttgcattta tgagaggtag aacacttgat aattcattta taatattgga
    36361 tgaagctcaa aatactactt ctgaacaaat gaaaatgttt ttaactagac ttggatttgg
    36421 ctctaaagct gtagttacag gagatgtaac tcaaacagat ttaccacaaa ataagaagag
    36481 tggtctaata caagctacag agattcttaa aggtgttcca ggtattgggt ctataatgct
    36541 aacagataga gatgttgtaa gacatgagtt ggtacaaaga ataataagag cttatgagaa
    36601 gcacgacaaa agagaagaat ttaaaaaaga agaacgtaaa aaagcgaaaa tgcaggaaaa
    36661 gactttcaaa agaaagtaaa agtgtagtaa tatagatata tagcattatt aatgaataaa
    36721 aagtaggtgt agtgaatgga tttgatacta gatgatagac aagataaatt agaagtaagt
    36781 gaggagttaa ttgaaaagat aaaggatata atcatagaat gtttagatta tgaaggatat
    36841 gatgataatt atgaagtgag tctttctttt gtagataata aagagattca tgaattaaat
    36901 agagaatata gaggagttga tagagtgact gatgttttat catttcctct tttaagtgat
    36961 gattttgagg atgttgagtt agaagaagaa tccctaggtg acatagtagt atctcttgaa
    37021 agagccttag aacagagtat agagtataac catagctttg aaagagaagt atgtttttta
    37081 atatgtcata gtatgtttca tcttttaggt tatgaccacg atacagatga aaatacaaaa
    37141 gaaatgagag aaaaagaaga acacatatta aataagttaa acataacaag ggagtagttt
    37201 ttatgaaacc agaaaaaact cgtcaaggta taattaaagc atttaatgca gctatagaag
    37261 ggatattgta tacatttaaa tttgaaagaa atatgaaaat acattattta ggttcagttg
    37321 ctgttcttat aataagtttg ttttttaact tttcaaaatt agaaatgata atgttactta
    37381 tgtccatatg cttagttgta gttgctgaaa tgtttaatac agctatagaa aaagctgttg
    37441 atttagtaac tgatgaatat catgttcttg ctaagatagc aaaagatgtt gcagctggag
    37501 gcgttctagt ggcagcacta aattcagtag tagttggata tattttgttt tatgataaat
    37561 tgacagatat atctggaata ttaatttata aaataagaga atcagaatta catataacct
    37621 tgatatgtat attattggtt cttatagctg ttgtagttgt aaaagcattg acttctacag
    37681 gtactcctct aaaaggagga atgccaagtg gtcatgctgc cttagcattt gctatagcaa
    37741 ctgcaattac acttatgact gaaagagttg ttgcctctac tcttgcatat ataatggctg
    37801 tattagttgc ccaaagtaga attgaaggaa aaatacatac cttttgggag actattgctg
    37861 gagctttgtt aggtgtgttg atagctatat tagtatttca gcttggaatg ttctataatt
    37921 aaaataaatg tacataaaat atttaaaata aaacaaatct gtgctaatta aatttttatg
    37981 atataatgta gagtattaaa taaaaataac ttttaattat tgtatacagg aggagttgtt
    38041 gtggataaca tagaattgtt aaggttggca gaagatgcca gacaacattc ttatgctcct
    38101 tactcaggtt ttagagtagg tgcagctctt ttaactaaga gtggtaaagt ttatactgga
    38161 tgtaatatag aatgtgcatc attaggtgga acaaattgtg cagaaagaac agctattttt
    38221 aaagcaatat cagagggtga taaggatatc tataaaatag ctatagcaag tgataactca
    38281 gaaaataatg agcaaacata tccatgtgga atatgcaggc aggtaattat agagtttggt
    38341 tctgatataa aaataataac gggatatact aaaggagagg tgtttgagca tagtataaag
    38401 gatttgttgc caaactattt ctctggaaat gatttaaaat aaatttaaaa gtataaataa
    38461 atttaagtaa ttaaaacaag aagataaaaa gttaggagac agttaatgtt caaatcaggt
    38521 tttgtcagta tagtgggtag accaaatgta ggaaaatcta ctttaatgaa taatgtagtt
    38581 ggagaaaaaa tagctataat gagtgataag cctcaaacta caagaaatac aatacaagca
    38641 gtatatacag atgaagaaat gcagatagta ttcttagata caccaggtat tcacaaacca
    38701 aaaaataaat taggtgaatt tatggtaaag gcagcaacag aagcttttaa aaatgtagat
    38761 ttaatattat ttgtagttga tgattctaaa aaaataggtc ctggagatag aaagataata
    38821 gaggatttaa gaagtgttaa gacaccaata attttagttg taaacaaaat agaccaacta
    38881 gaccaaaaag atgagctatt tgatataatc aaaatgtatg atagagaagg catttttaaa
    38941 gaaatagtac caatatcagc attaaaagga aagaatacgg ataccttaat aaaagttata
    39001 caaaattatt tagaagaagg gccaaagtat tttccagatt atatgattac agaccagcca
    39061 gaaagagtat taatagcaga acttataaga gaaaaagttc ttcactatct taatgatgaa
    39121 atacctcatg gtgtagctgt tgaaattgaa aaaatgaaag cgagaaatga taaggaaata
    39181 gtagatgtat ctgctgtaat atactgtgaa agagattcac ataagggaat aataatagga
    39241 aaaaatggta ggaaactaaa aggaataggt aagtcagcaa gacaagatat agaattgctt
    39301 ttaggttcac aaataaatct tcaattatgg gttaaagtca aagaaaattg gagaaattta
    39361 caaaattata taaataattt tggatataat gataaataaa ggtgggttat atggatagga
    39421 aactggatgc ttcccaagat ttattatatg aagtaaaatc attaattgat aataataaag
    39481 tattggagtt aagagaatta atagaggaat atcatataat tgatatattc gatataatgg
    39541 aaaatttaga ggaagacatg aaaattcaat tatttgaagt acttccttta gatatggcat
    39601 cttctatatt agaagaaggt agtgtagagt tttttattag tattttatct aaactggatg
    39661 tagaacactc gaaaaatata cttgaactta tgtctcttgg agatatggca gacaagttga
    39721 gtgaacttga agaagaagaa agagaacaca taataaatct tttgaatcaa gagaatgccg
    39781 attatgtaaa agagttacta ttctatgatg aagattctgc tggtggaaca atgaccactg
    39841 gatatatttc tataaataaa gatatgacag ctcttgaggc tatagaccat atgagagaag
    39901 aagctgaaga agctgaaact atttattata tatatgtggt tgatgatgaa gaaaaactag
    39961 ttggagtatt gtcattaaga gaattaataa tagctagaga cgcaaatata gtagaagatt
    40021 tgatgagtga aaatataatc tctgtttatg tagatgaaga tagagaagaa gcagtaagat
    40081 tagtatctaa atacaattta atagcaattc cagtagtaga cagacaagaa aaattaaaag
    40141 gaataataac agtagatgat ataattgatg taatggaaga agaagcaact gaagatatgt
    40201 ataaatttgc aggaagttca gaacatgaaa gagaagttgc tgaaaaagaa aaccctacat
    40261 tgagagagca aataatatca gcacttagag gacgattacc ttggttaatt attaccttag
    40321 ttggagggtt gttggcttcg ttaatacttt ctaacttaga ctatataatg aatcctgtat
    40381 atgctccatt agtatttttt atacctgtag taattggtat gggtggaaat attggaactc
    40441 aatcatcatc tgttacagta ataacattat ctaataagga tttaaatttt agcaatgtgg
    40501 ttagagaagg tattgtaggt attattacag gtcttttgtg tagtataata acaggtattg
    40561 taatttactt tgttatgaga aagttagaca ttgtattaat tgtttcaata tcattattta
    40621 taaatatggt tttaggtgca acaataggtg cgtttatgcc tgttttatta aaaaaaatgg
    40681 atgcagaccc atctacagtt tcatcaccaa ttatatctac agctcttgat ataactggta
    40741 tagcagttta ctttataata acaacggcat tattgtcaaa aattgtttaa taactttatg
    40801 tatgatttat cctcttctta ctaaaaatat aagtataaat gtaagaaggg ggttttttaa
    40861 aaatgaacaa tatcagttgg gaagttttta aaaaaacagg tagtatagat gcatatttat
    40921 atttctgtga ttgcaaaaac atacatgaag aaattgaaga agtaagggag aaaaaagaag
    40981 acgatgataa tcctgaacac ccaggggata gtacttaaag ctataaggta taaggaaagt
    41041 gatataatac ttacactatt tacaagaaag cttggaaaag tatctgcaat agcaaaagga
    41101 gctaaaaaaa ataagagctc tttgctttca tcatcacagt tattttctta tagcaatttt
    41161 accttaaaaa aacaaggtaa tatgtacaag gttactcaaa gtgaaataat aaaaagtttt
    41221 tataatatat cctatgatat agaggcattt tcttatgcta catatattac aaaattagtt
    41281 gaaaattcta tacttgaaaa tcagactaat aataggctat ttatattact tgcgcagact
    41341 ctgtatttgt atacacagga taatacagac aataggttta taacagcagc attcgagtta
    41401 aaatttttag actatatagg atttaaacct atagtaaata aatgcattaa ttgtgaatgt
    41461 aaaattttac aaaattctgt gtttaatatc tacgaaggtg gtatactatg tagtaagtgt
    41521 agtaaacttt ttgataataa tataaaatta gacttaacaa ctataagtct tatggaatat
    41581 gtattaagaa atgatatttt aacatgtagt aaagctaaag tatcaaaata tataacacat
    41641 gaacttgaga atattctaga caagtatttg aaagtttatg ttgataatat taattttaaa
    41701 tcattacacg tattgcaaag tgtaaaaaat aataagggag tggataatga tgagtagtaa
    41761 tataactatt gaaatggttg attcagtctt tgaaagagtt ccaggagcaa cttatgcaga
    41821 agcaaaagaa gcattagtaa tgtgcaatgg agatgtaatt gaggcagtaa tatatttaga
    41881 aaataaaaaa aatacttgta attgtaaagc aaaatctgct aaagaaacta tggaagaagt
    41941 atttggcaaa gatggagaaa atataaagtt tcaattaaaa gagcttctta gaaaaagtag
    42001 tgtagtgaga ataatagttg aaaaagatgg aaaaactatg atgaatattc ctttaacagt
    42061 tggagttgtt ggattagctt ttgtaccatt agctacttta gttggattat cagctgctgt
    42121 tataagtaaa tatcgtataa aagttcaaaa tgaagaagat ggagaaattg tagatttagg
    42181 tgaattgaat gaagaaaaac ttcacgtttt gaagaatatg ataactaatg cagcaaaaga
    42241 tgtgaaggat gtagtagttg acaaaaaaga agatgacaaa gatgtaactg ctgaccttat
    42301 gaaagaagaa tctgaaaaga ataaagaaga cgaagacgaa aataaataga tataaagtga
    42361 cttttaaaaa atgaagagaa gataattata agaattatca ctaacattga caaattttat
    42421 agaatttgat attctaaaag ttgtagaaga actattaaaa tagcctttcg tgtagacgag
    42481 aggctttatt gttataggag ggatttttat gaattttcaa gagatgatac tggcgttgca
    42541 aaaatactgg tcaaagcaag gttgtatcat gatgcagcct tatgatattg aaaaaggtgc
    42601 aggaactatg aatcctaata cttttttaag atcattagga cctgagcctt ggcaagtatg
    42661 ctatgtagag ccttcaagaa gaccagcaga tggaagatat ggtgaaaacc caaacagact
    42721 atatcaacat catcaattcc aagttatact aaaaccttct ccagataata tacaagaatt
    42781 atatttggaa agtttaaaag agattggaat tgacccaagt gagcatgaca taagatttgt
    42841 tgaagataac tgggaagctg ctacagttgg tgcttgggga cttggatggg aagtttggct
    42901 agatggtatg gaaataactc aatttacgta ttttcaacaa gtaggtaata ttgaatgtga
    42961 gcttgagaca ggagaaatta catatggatt agaaagatta gctatgtaca ttcaagaagt
    43021 tgatagtgtt tatgatttaa aatggaatga taaaataact tatggtgaag tatttaataa
    43081 agctgagtat gaaaactcaa tgtacgcatt tgaattatgt gatgcagata tgttgtttaa
    43141 tctgtttgat atatatgaaa aagaagcatt aagacttatg gaaaatggcc ttgtaatacc
    43201 ttcatatgac tatgtgttaa aatgctctca tgcatttaat acattggatg caagaggtgc
    43261 aataggagtt agtcaaagag cttcatttat aggtagagtt agaaatatgg caaagactgt
    43321 tgcagaaact tttgtaaaac aaagagaaga aatgggattc cctcttttaa aggacggtga
    43381 caaataatga aaaattatct tttatttgaa atcggtgttg aagaaatgcc atcaagattt
    43441 gtaggcagta cactagaaca attaaaaaac aatcttagta aattatttga tgaaaataga
    43501 atagcttttg ataaaataaa tgcgtatggg acaccaagaa gacttacttt agtagtcgaa
    43561 ggattgagtg atagacaaaa tgatttagaa gaggaaataa agggtcctgc taagaaaatt
    43621 gctgttgatg cagaaaataa tttaacaaaa ccagcattag gatttataaa aagcaaagga
    43681 ttaagcgaat ctgacatata ttttaaacaa gttggaaaag aagaatatat atttgcgact
    43741 ataaagcaag atggaaaaga aacttcagaa gtactaaaag acatattacc agagactata
    43801 aaatctgtag tattcccaaa agctatgcgt tggggaggaa aaaatcttaa atttgcaaga
    43861 cctataagat ggatagttgc attgttaaat gataaagtat tagagtttga tttagaagga
    43921 ataatatctt ctaatgtaac aaaaggtcat agatttttag gtgaaagtac aatagaagtt
    43981 gattctatag aagattattt tgaaaaatta gaaaaaaatt atatagtttt agaccaaaac
    44041 aagagaaaag aaatgataag aaaacaatgt atagaagtag caaattcttt aggtggagaa
    44101 gttgaatttg atgaagattt acttgaagag gtaacttatt tagttgaata tccaactgct
    44161 ttttatggag aatttgatgt ggattatata aaactaccaa aagaagttgt tataactcct
    44221 atgaaacaac atcaaagata ttttccagta cttaaagaag gaaaactgtt acctaacttt
    44281 atagctgtta gaaatggtga ttcttacaga atagacaatg ttaaagctgg aaatgaaaaa
    44341 gttttagaag caagacttgc agatgcttta tttttctata gagaagatac taagagaaac
    44401 ttagaaagct acatagaaaa attaaaaact gttgtattcc aagtaaaact aggaactatt
    44461 tacgacaaaa ctttaagact tgaaaaatta agtgctgata tacttgatag tttaggttta
    44521 gtagatgaaa aggcagatac tataagggct gctaaattat ctaaggcaga tttagttact
    44581 ggaatggtag gagaatttga tgaattacaa ggttttatgg gaaaagaata cgcaaaagtt
    44641 ggaggagaga atgatgttgt aagtgaagct atttttgaac attatcttcc aagatttgca
    44701 ggagatatac ttcctaagac taatgcagga gttgccttat caatagctga taagttggat
    44761 tcaatagcag gtttctttgc tataggaata caaccaacag gttctcaaga cccatatgct
    44821 ttaagaagac aagctttagg tatacttagt atacttatgg acagaaaagt tgctgtggat
    44881 ataaaagtac ttattgaaca tgctttagac aattattctg aattagattt tgataaagaa
    44941 gaagttgttg agcaaataat gaatttcttc aatgagagag taaaaaatct atttaaagat
    45001 ttaggaataa gatatgatgt tgttgatgct gttttaagtt ctgatataaa tgatgtttct
    45061 gatatgcata tgagagcttt agagcttaat aattggctag aaaaagatga attagtggag
    45121 atgcttactg catttaatag agtttctact ctagctcaaa aagcagaaag tgataaaatt
    45181 gatgaatctt tattaaaaga agatgctgaa attaaacttt acaatgaatt taaacaagta
    45241 aagataaaag ttaatgaatt attaaaggat aagaaatatg gtattgcttt agatgaattt
    45301 gcatctttaa gaccagtagt tgataattta tttgatacag ttatggttat ggataatgat
    45361 gaagctatta agaacaatag acttgcttta cttaaacaag tatatgatac tatgctagaa
    45421 atttgtgatt tatctaaaat tgtttataaa taaaatttaa actatttata agaaataagg
    45481 ctgtctcaaa atagagatag tcttattttt cattgttgag atgatgaaaa tatatttgat
    45541 ttcatagaaa aagagtgtct cataaactaa aaagttcatt ttgagacacc catgtttttt
    45601 gtaagtaaat ataataaact atattttata cttatcagtt attttgttta aaatattatc
    45661 atttgaattt acccattcat aaaaattgcc tgatgatgcg tccgatattt tataaagcat
    45721 ttcaggaata tcactagctt taaaatctcc aagtgatttt cccaatctag tcttacctat
    45781 ttcaaaactg cctccaacaa ataattcaaa tgtatctgta gatataccat caacattctt
    45841 ctttttacca cataaaccta tgctaccaac ttgatgaaca ccacatgaat ttaaacatcc
    45901 tgatatatat aacttaggtg ctttatttaa aatttcttca ttattttgta atctaaaata
    45961 atctatgatt tcatgtaaca ttttctgact attttgtatg cccatttgac aaattggaac
    46021 acctatgcaa gatatacttt gttctaattg agaattacaa ctaatagttt tacttatttc
    46081 taatattctt tttgcttcat ttccatttaa atttaaaata tataatccct ctgtcattcc
    46141 tagtctaatc ataggatttt caacattatc taattcttta agtaaagtac ttaaatcctt
    46201 tgttaacaaa atacctccaa ctggatgtat atatacagtg tataaaccat cctgtttttg
    46261 aggtattagt ctagaatctt gtatatctat tttaactcca ggtttagagt aatctatttc
    46321 ttcaatattg agttcaagac taccattttc tttttctaat ttatagtatt ctttaaattt
    46381 ttctaagaat agttcttcac caagtgattc gaccatatat ctaaccctag ctctgttttt
    46441 attttcataa tttccataat ccataaagaa tttaatcata ccttcaacac aatataaggc
    46501 atctttcggc tttataagtt catcaagttc taaagcaact ttgggttgtt tacctagacc
    46561 tccacctaag aaaactctga aatatggttc atcatttttc aaagtagcaa caaatcctaa
    46621 gtcttgtata ctacaatgag cagtatctgt gtaacaatta gaataagaaa cttttaattt
    46681 tctaggtaaa tggtatgtag tagcattttt gataaaatat ttatcagtag caactgcata
    46741 tggagtaaca tcaaagactt cactagggtc aactccagat aatggagata atccgacatt
    46801 tctaggataa ttaccaccac cacctctagt gaatatatca ttttttattc cttcttccat
    46861 gatatcaaca attgaattta tagataaatc gtgcaattgt atagcttgtc tagttgttaa
    46921 gtgtatctta tctaagttgt gtttaatagc tatttcatag attttattaa gttgatactg
    46981 agataaaact ccagcagata ctctaagtct tatcataaaa gattttttgt ctctttgagc
    47041 ataaacacca tatccaccag aaaatccctt atattgcatt ttatttattt ctccatttaa
    47101 aaattttgaa gaatattctt taaaattagg tagttcattt aacaatatct ttttaaaatt
    47161 atccattatt tcacctcatt gttagtcttg t
//
LOCUS       DAEQCW010000016        46761 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.016, whole genome shotgun sequence.
ACCESSION   DAEQCW010000016 DAEQCW010000000
VERSION     DAEQCW010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 46761)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46761)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46761
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.016"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(133..702)
                     /locus_tag="KRO40_000982"
     CDS             complement(133..702)
                     /locus_tag="KRO40_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBH2091813.1"
                     /translation="MKLPIALSNKHVHLSQADIDVLFGAGHELTKFKPLSQPGQYACE
                     EKVDLVGPKGTLKGVRVLGPARAHTQVEISLADGFPLGVKAPIKESGDIAGTPGVKLV
                     GPAGEVEMKEGVIVASRHIHMSNEDAAKFGVTDKQIVKVKTSGPRALVFENVLVRASD
                     SFNLEMHVDMEEGNAAGVKNGDLVELIVD"
     gene            complement(774..1382)
                     /locus_tag="KRO40_000983"
     CDS             complement(774..1382)
                     /locus_tag="KRO40_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2091814.1"
                     /translation="MDSNDKKGLKSPEIIIINGSPRINKNCSFIANEVKAMLEECGLS
                     CKIFNIYNMDIEYCTACGFCEKTGYCKFNDDMKPLYKMFDDSKGTIVISPVHFDSISA
                     KLKTVVDRTQAIYASKYVLNKPSIDRSKKRIGMYIAVGGSKSYDSQFKGGQIVMDFFF
                     KSINTKLLHNIYLNNTDDVSYIDNQEFKDIIYKNLKIYIDSI"
     gene            complement(1390..3153)
                     /locus_tag="KRO40_000984"
     CDS             complement(1390..3153)
                     /locus_tag="KRO40_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="HBH2091815.1"
                     /translation="MTNGSYKMKNLVEISAMVTESTDFFNIKDDIIEKMLEVVHPTKA
                     CVNLFYKNDSKYAYLVCSQTLEYVPQIFPINSLKGAKIDFDTYPEYIHEAVNEKKIIY
                     VENVFEDSRAEGERDLAKAEGYIGRIVFPFIINNVVVGFMTCFLKEDDYITEQDIDFI
                     SSVASLLSLSIEITNKNNNVQILIDKLRGSISAINEATKKLYLNKSIDGFLENLSKQA
                     CNITNSKEALIIINSHHNKDAIVSCYNVEQKKKTNLYPMIDMFLKKESLGGYLNNLKP
                     CSKKGINLESYIYYKLQDKNDTIGCIVCANSKNYTSDDLNILSILSKQVSVGMQLYEH
                     NEKEVKHKVLENELNILNKQQQLIMDKGKMDCNDEKELYFYHKPARVVGGDFYYATKV
                     DDEHIVYIVADVMGHGMVSNYVVAMIKGAFKVLCNQYNTPREIMTNLNRMLYDEFDKM
                     GVFTTCLIGIIDTKENMITVSNAGHYSPVVVKKDGTIENNLNCKKGIPIGIMEDATYE
                     NNTLSMEDYAMVCMYTDGILEIKNSSKEEYGINRLENFLKENFRLNQQLIVENLKLDL
                     KNFSSKDNYDDDILIVMLKDR"
     gene            complement(3196..3663)
                     /locus_tag="KRO40_000985"
     CDS             complement(3196..3663)
                     /locus_tag="KRO40_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091816.1"
                     /translation="MKMLNGIIKLFYSEIVKTKINNLDSSGYSLRDECKEIRNITLKI
                     DSVFFKLLKLAFGSILLMVAFNLNMVLGIGVFLVGVVYILYKRNMEEQVKEHINNVKN
                     NIDISKITFMDEKGRTGLNALITLLLIGLLTGFNWILVASFVVVFVFTIKNVC"
     gene            3846..4307
                     /locus_tag="KRO40_000986"
     CDS             3846..4307
                     /locus_tag="KRO40_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091817.1"
                     /translation="MQIEQLDLETRNKIYCYTKKILRKYQKGITSGKLTADKFADNIL
                     SQDFISSILNEKIVNETNFKISYRNYIETLINIQNENLSNLRKKSTKTAKCFNISQIT
                     QLKNLLSNTGYNLLIPYKYLTARDIEGIVTLINTGSIELGNERIYNYISKA"
     gene            complement(4400..4570)
                     /locus_tag="KRO40_000987"
     CDS             complement(4400..4570)
                     /locus_tag="KRO40_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091818.1"
                     /translation="MSSVNFEDLKNKFINSDLDEKIRIYTTTEGLSVEQFKELLKYYP
                     IQHLSKLEKALG"
     gene            complement(4759..4980)
                     /locus_tag="KRO40_000988"
     CDS             complement(4759..4980)
                     /locus_tag="KRO40_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000002841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBH2091819.1"
                     /translation="MASNNNNNRTVVPGAKEALNQMKLEIANELGMSNYQQVDKGNLT
                     ARENGYVGGYMTKKLVEMAEQQMAGKSNR"
     gene            complement(5064..6290)
                     /locus_tag="KRO40_000989"
     CDS             complement(5064..6290)
                     /locus_tag="KRO40_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH2091820.1"
                     /translation="MKKVVIIGGGPAGMIAASTACEKGYDVTLIEKNHKLGKKLAITG
                     KGRCNITNACEIEELIENVPTNGKFLYSAFYTFTNDDVISMFNNLGVKTKTERGKRVF
                     PESDKAFDIVNALERQLKSKKVNILLNSKVEKIISKNNKIEKVILNDKKEIKCDSVVV
                     ATGGLSYPLTGSTGDGYKFAISQGHTIIDTKPSLIGIEVQESFTKDLEKLSLRNVEIR
                     VFNSKQKKVYSDFGELEFTKFGLDGPIIKSASCRMKDTRKENYTILLDLKPALDEEKL
                     DKRVQKDFQKYTNKKFEKALDDLLPKKLIPIIINLSEINPNTVVHQISREQRKNLVHL
                     LKNLKFTVKRYRPIEEAIITSGGVKVNEINSSTMESKLVEGLFFAGEVIDIDAYTGGF
                     NLQIAFSTGYLAGFNC"
     gene            complement(6352..7284)
                     /locus_tag="KRO40_000990"
     CDS             complement(6352..7284)
                     /locus_tag="KRO40_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HBH2091821.1"
                     /translation="MDIQLNILLFFQNLRNPILNFIFLVFTISTEAPLLILITTIIYW
                     CINKKCGQKILFAIIGNFVVNLGIKEFVKAPRPIGIKGLESLRVSTAGGYSFPSAHTQ
                     TATTFWVSIMTIFKKRYLHLIGAVMVLGVGLSRLYLAVHWPIDVIAGWILGIFFTVVF
                     VKIFDYIDDNKNYILLVVLLIPFIIVAIFLNSPEYFEKFGIIVGFVFGYMVEDRFVKF
                     NTDNNNKKINFSNKNKGSKNIIFSRICRFLVGIVTIGMLYIGIKLFISMLIVTLNISD
                     STMSIIFMNFIKNTVVVFYGIAGAPALFKLLKLN"
     gene            complement(7373..7900)
                     /gene="hpt"
                     /locus_tag="KRO40_000991"
     CDS             complement(7373..7900)
                     /gene="hpt"
                     /locus_tag="KRO40_000991"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBH2091822.1"
                     /translation="MYKVTGKMLTEEQIKEKVYELGKKIEEDFKGEDLLVVGILKGAS
                     VFVSDLIRCIDLDVNIDFMSVTSYGNSTESSGTVKILKDLDVDIEGKNVLIVEDIIDS
                     GLTLSNLVAALKTRNPKSLKLCTLLDKPQRRKANIPVDYVGFVIEDKFIVGYGIDYAE
                     KYRNLPYIGIVEDVE"
     gene            8129..9205
                     /locus_tag="KRO40_000992"
     CDS             8129..9205
                     /locus_tag="KRO40_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003415975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2091823.1"
                     /translation="MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIV
                     NNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGSGATELISSFIHTINPKQALLLS
                     PAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGF
                     AFTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTP
                     GIRLGYGLISNTNVKNEINKNLDLWNINIIASKMGEIMFSDLDFISNTISLMNTERDY
                     LLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKIIIRDCCSFEGLDEY
                     FFRVCILKPNENKLLISSLKAIFK"
     gene            complement(9291..10499)
                     /locus_tag="KRO40_000993"
     CDS             complement(9291..10499)
                     /locus_tag="KRO40_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="HBH2091824.1"
                     /translation="MKKKIGLVPKLIIGIIVGILIGSYAPEIIVQILVTVSTLFSAFL
                     KFVIPFIIIGFVTAGIADLATGAGKLLGITTGIAYGSTLIAGLLSFAVSTLIFPNFID
                     ASVASQIGDPEAGMLAPIFTIPLEPMVDVTAAIVFAFVMGLGISALRNHGKGETLFNF
                     FQEFQGIVTKTLSTVIIPLLPLYIAGTFANITIAGEVWTILGVFWKVYLVVIPLHFVY
                     MACQFTAAGVFSGKNPVRMLKNQVPGYLTAIGTQSSAATIPVNVGCAEKNGVSKQIRE
                     FVVPLCATIHLSGSMISITGFTTAVLMMNGMPHGIGVLFPYIAMLGIAMVAAPGAPGG
                     AIMSALPFLPMVGIPSDGGLASLMIALYLTQDSFGTACNVSGDNAIAVVVDKINDGMS
                     KKGNKEEQSA"
     gene            complement(10660..11049)
                     /locus_tag="KRO40_000994"
     CDS             complement(10660..11049)
                     /locus_tag="KRO40_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1232 domain-containing protein"
                     /protein_id="HBH2091825.1"
                     /translation="MEFLKIIINIVLDILKKILVRFKNAKFGLVFVFDLLKLPDFMTD
                     KRINIVDKIKVISVLIFTISYFVSGVDIIPEMIAGAFGFIDDAIVLIWSIGIVNEEIN
                     KYRVIAKKDKHSNIIENVEFSIKDEEE"
     gene            complement(11153..12154)
                     /locus_tag="KRO40_000995"
     CDS             complement(11153..12154)
                     /locus_tag="KRO40_000995"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HBH2091826.1"
                     /translation="MSTIIPKDYKSSLNVIDTQIAIKKLKDFFEMRLSNELNLIRVSS
                     PLFVLPETGANDNLNGEKAVSFDIPFMNKNAEIVQSLAKWKRLALKKYGFEVGSGLYT
                     DMNAIRKNEELDNIHSLYVDQWDWELVIDKSSRNEKTLKDVVKRLYGVFKDTEIFVCS
                     MYEGIKEILPEEITFITSQELEDMYPELSPKEREDKIVKEKKAVFITQIGKTLISGEK
                     HDGRSPDYDDWELNGDILFYNPVLDSALELSSMGIRVDEESLDRQLKLAGCEERKEFD
                     YHKMLLNGELPYTIGGGIGQSRICMYFLQKAHIGEVQVGVWPQDMIQNCSSAGIELL"
     misc_binding    complement(12213..12468)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(12602..13792)
                     /locus_tag="KRO40_000996"
     CDS             complement(12602..13792)
                     /locus_tag="KRO40_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2091827.1"
                     /translation="MSKYNFDRVIDRVGTDCVKWDFRTNCSTKAQKDGLPFWIADMDF
                     ECAEPIIEALRKKVEHKIFGYSSNDSDKYFNAVCDWYKRRFNWEINRKDIIFSPGVVP
                     AVAILVRILTNSNEGVIVQKPVYYPFEAKIKSNNRDVVNNPLIYENGTYRMDYDDLEE
                     KAKCSNNKVLILCSPHNPVGRVWREDELKKVVEICKKYDLWIIADEIHSDLIRKGFKH
                     TPLQSLCPEYKDKIVTCIAPSKTFNLAGMQLSNIIVNNDELKKKYQEEVTAVGVATSP
                     NPFAIVATIAAYNESEDWLNELNDYLDNNIQFIDEYLKENLPKVKLVYPEGTYLAWLD
                     FTAYGLNEVELEDLMFKKANVLFDEGYIFGKEGIGFERINVACPQSLLKECMDRLKTI
                     FENL"
     gene            complement(14073..15194)
                     /locus_tag="KRO40_000997"
     CDS             complement(14073..15194)
                     /locus_tag="KRO40_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 peptidase aminoacylase family protein"
                     /protein_id="HBH2091828.1"
                     /translation="METNKDYIEYVHKVYDYLHTIPEKGFEEYKTSEFVLKELEKMGF
                     ENINKGIAGTGIIVTIDSKKEGPVFAIRADMDALEFIIDGEKKMIHACGHDGHTSMLL
                     TAAKLIKERNLVKRGKLKILFQPGEEKLYGALRVIDSGLLDDVEEMVGMHLRPGQDCR
                     LGKAIPAMYHCASCIMEFTIKGITCHGSKPHLGVNAVDAVCLAVNAINAIRVNPAIPN
                     SIKVTNISVKGETYNNIPDEAFMALDIRAESNDIIEELKEKAIHAVKTAVSSINAEAV
                     LISKDGVPAAEFDEELVNLAEETIKDVLGADASIGIFKNSGGEDFHYYTQKLKCKTTY
                     IGLGADATPGFHNPNVTFDTKALEYGVDIWCRLVEKRLG"
     gene            complement(15255..15740)
                     /locus_tag="KRO40_000998"
     CDS             complement(15255..15740)
                     /locus_tag="KRO40_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjiG family protein"
                     /protein_id="HBH2091829.1"
                     /translation="MSEVAKKEVKVKKGNVIDAFIGGARNGFQISTNSMAPNVIFGFA
                     IISVFNLTGLLDVIGTIFTPVMSIFGLPGVAATAIMTIFISMGGASGVIAGLFTAGQI
                     SQAHVAILLPMLLLSGAQIQFMGRLLGTAELKTKYYPHMFVIATLNGCIAMLIMNYFV
                     V"
     gene            complement(15742..16410)
                     /locus_tag="KRO40_000999"
     CDS             complement(15742..16410)
                     /locus_tag="KRO40_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091830.1"
                     /translation="MSKLESTTEKVEVKWYGYVALILGALFFSGIFKDAPGPLKVLDF
                     NNVLGSFGTLGTINDGVGTLAANFRGDGGTGPRDGWLYALTLIPSVMFALGVVRVIDH
                     LDGMKAAQKLLSPLLKPLLGLPGFAGLTLIASLQSTDAAASMTKELKDDGYIDEKQKA
                     VFCAFQFSGASAITNFFASGAALFPFIGDVPIFIPLALILIMKFVGANLLRLYLNKFD
                     KGEA"
     gene            16800..18824
                     /locus_tag="KRO40_001000"
     CDS             16800..18824
                     /locus_tag="KRO40_001000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2091831.1"
                     /translation="MDKKKLILITHDKLNSDHYKEELTNFFGDEIIIETQNILDGIKE
                     NLEGDVVLSLSPLTSNFLIKHFKEDIEIIHGTKALSKLGYEKMMKLPPGTKSLLMTTN
                     KTSAFEMATYLYKIGINHIDFVPTYPDCDEIYDLDTAITPGQIRFIPKYIKNIVDLGW
                     RKISLDTYMSLLVVLKLKNEKFIEKLYKLSKETLSHDFLNTSLDNISKLKTILYMTID
                     EIGDGLIFFNTFNKVTFVNKSLLNMLGLDEKLIKSPSLMEYMPNSFLDKITKNLNIDN
                     MIIYIDEIDKKFILSKKPFYLYKNIEGCLITLKDVNNIEILEQKIRSDSVKRGYVAKY
                     KFNNIIGNSSIIKDCIKKAKKMALTDNPILITGETGTGKEAFTQSIHNHSNRKNKPFV
                     AINCASLPSELLESELFGYEDGSFTGAKKGGKKGLFELAHTGTIFLDEIGDMPHDLQV
                     KLLRVLQEKEIRKIGGTSIIPIDVRILAATNKDLEKLIIENKFRMDLFYRISMFTLDL
                     PPLRKRLEDIPLLLESFLKELPYKNIKLDKSLLEALNSYTWMGNIRELRNCIEYMAYM
                     GSNYLTINDLPQNISSKLNNNHMSSNMSIFNDLNQYDKNICISILKSLHMKPMGRTKL
                     MKFMEYNVTEYEVRNMLEYLTRNGYLISSKGRKGSSITEKGIKIIENNII"
     gene            complement(19054..20241)
                     /locus_tag="KRO40_001001"
     CDS             complement(19054..20241)
                     /locus_tag="KRO40_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3798 domain-containing protein"
                     /protein_id="HBH2091832.1"
                     /translation="MLRKITAFMLSICLIIGLTGCSLLVGKKDKEKIIDDFKVAVVTQ
                     PLSENKVQYNMVEEMAKEYEEENKIDKDKDGQTKVKQTIKHVVLPENFTSNIDSAINK
                     IVKLADDKEVQAIVVSTDQAGLLPALQKVKEKRPEIITISAPMGDDKNQLSQFVDVNL
                     GVSAEERGKVLAERSKEMGAKAFIHYASTDDLKDVNIAKRLEMIKETCKNIGLPFVQV
                     NTPNINTEEDKNKVKQFLNEDIEKQVKKYGKDINVFGVNEYMDEVILTKALELKYIVA
                     EQSNPSPIQTYPSVMGLKISEKDAQNYDKINDMISEKAKAFGMSNRLGGYPMPMDAFL
                     PSVAIYLATEMVKQDLTQEDVCDPDYLEAFTELRFGIGSEFTPLTEVLYNYQSVILSQ
                     LIY"
     gene            complement(20443..21714)
                     /gene="brnQ"
                     /locus_tag="KRO40_001002"
     CDS             complement(20443..21714)
                     /gene="brnQ"
                     /locus_tag="KRO40_001002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH2091833.1"
                     /translation="MRDIFIVGFALFSMFFGAGNLMFPPFLGMESGKDWLIPLIGFVV
                     ADAGIAMLVIIATARCKGSMDDVLRRAGKGLARVMSVAALACLALLVIPRTCATTYEM
                     GIMPIFGDHGPVAKAVFSIIFFGLTLAFTIRSSKVIDIIGKYLTPALLLVLFVLIVKG
                     IISPAGPMSPEHMIDKNLFGEGISQGYQTMDALGAASMATIMLMSIIAKGYTSDKDQI
                     GMTIKAGFVACVFLAVVYGGLTYLGATVSTLYDTSIPQASLLVEITSILLYGQVGKVI
                     LGVIVALACLTTSTGLTASISTYFEGISKASYKQLVIGICVASMLISNLGVDSIIAIS
                     VPILQTIYPVLLAIVVMELAGKHIKNDNAFKGAAYVTLVISLLSAINGMTGAVPFIQS
                     LPLAGLGFNWVIPAILGGIVGNFIKSNKQVA"
     gene            complement(21855..22508)
                     /locus_tag="KRO40_001003"
     CDS             complement(21855..22508)
                     /locus_tag="KRO40_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH2091834.1"
                     /translation="MTKIIKVQKPKFTGELEIIENLEDILEDIFNDEKIFNKIIENEV
                     ISDLDSVRVSFESCIFRNVSFENCNLKKIDLLDVVFENCNLSNTFFDGGSIYRVEFKN
                     SKLIGVRFDDCILKNVLFKDVLGKYSNFSFSKFKIVSILDSNFENSVFQEVKGDNLVF
                     EYTNLKKANFNGTKLSGIDFTTNNIEGIEIGIDDIRGAIFDVSQAIDLTKLMGIIIK"
     regulatory      22837..22938
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            23011..24354
                     /locus_tag="KRO40_001004"
     CDS             23011..24354
                     /locus_tag="KRO40_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBH2091835.1"
                     /translation="MVPNTNNVQPGGNNSSLSFLDKMFKFSERGSSLKTEVIGGVTTF
                     LTMAYIVFVNPAILSEAGMDKAALITVTILATAIGTLIFAILGNAPFALAPGMGLNAF
                     FTYSLVIGAGIPWQTGLGVVFLSGCVFFTLAVTGLRKTIADAIPRELAVASSAGIGLF
                     LAFVGLKNMGVIIANPDTIVSLADFTPTVLIALFALILMAILEYKKVKGGILISIVVA
                     TIISVIFGFVELPTAIISTPPSIAPVAFKLDIVGALKFSLIGPIFSFMFIDMFDSLAF
                     LITCCKQMGLEDENGEIKDLGRMLYADVSSTLIGSFLGTSTVTTFGESASGIAAGART
                     GLASIVTAALFLATLIFTPLLGIVPTYAAAPALVMVGVFMFESIKQIDFADSKIAVPA
                     FVTVLLMPLTYSISIGLCFGFISYIIMHVVAKETDKISITLWIIGLLAVVNLVLS"
     gene            24533..25897
                     /locus_tag="KRO40_001005"
     CDS             24533..25897
                     /locus_tag="KRO40_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2091836.1"
                     /translation="MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIV
                     DKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADDVVLLTWLRERIWPYESSFNYED
                     SLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEA
                     WQKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGI
                     HMHIAEIADEISFVKQNNGVGTVEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVK
                     VSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLMRDMYLTSLIHKGRT
                     LNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIG
                     NIVYSMTSENVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKF
                     KIIK"
     gene            complement(26075..27940)
                     /locus_tag="KRO40_001006"
     CDS             complement(26075..27940)
                     /locus_tag="KRO40_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HBH2091837.1"
                     /translation="MENVFKRLQEFNGYDGYKESFEMNYLCIYESIPLREQVELANNL
                     VDEILNMYKSESNEIYLLEGSNSKSLICYFEIFMKKINTLVKEMIIDEKWLYKLTKEL
                     IYKSKKVEYVKLGLVLSEKYLNVENLREVVDTFSKSGEYVFYLSNTIKKLEFYNTYLF
                     NLSKKATGSIKVFAIVNMENLDSKINSYLIEDGYKDTKYERLLMNYIISIVDLNEYLE
                     KRDLDKEKINNLARLICNYLLSVEFKYIGNKLELVNRFLPTVVNYGTNFESLYSIFLI
                     AINVLKDENIECNKIEFEKEINGILLSEKWKNIYFEALRDASGKTEDIIKMSEIYDVN
                     LSFDDLLPYLNRDIRDFEVYWHISKKGTTSSRLKLLNFFEETFKIDDLIGKMKDIEKD
                     KLTQEYYDDMLFFIVLKGSKSLYPEGKNISLKGIFGNINEVRKESINILKRYREKLSL
                     EELKIVKEAYEKEKNVILKDELRRVLYESNNLKKEFVNIEKIKVDEHGKDIYLTSIAV
                     AGSRFRNREYLEKELEKSKIYYLTREKDNLYDEKAIKIVGETGYVIGYVPRKENYILS
                     NLLDGGKLLYCRVTEYNLYEDCIYANVYLSYKDVIETVENSLKMVLDKSRIKLIN"
     gene            complement(28176..29393)
                     /locus_tag="KRO40_001007"
     CDS             complement(28176..29393)
                     /locus_tag="KRO40_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2091838.1"
                     /translation="MNNKKYYPTAIALYFSYFLLGIGISILGQYKPEFSSMWGAKTLS
                     DGTLDVSIVLAVIAALGLGRLISYPFAGPISDKYGRKVSGLIGNFLHAIFFVGIVFSP
                     NFYIAYVFAIIGGAANSFLDTCVTPSCMEIFASLGTIANMFTKFTIALAQFLLPFIIG
                     FVAANSISFKVIFIVTAILIVVDAFLIAVLPFPPANNVIDNKGKTVKSEKMKFTPTSI
                     ALVCIGFTCTSTFVLWLNCNQELGKLYGMADPTKIQSFYSMGVICAVLITSLLIKKYI
                     KPIRILVIYPIIALLMLLVVYFVQTPTICMLGGFVIGYSAAGGVLQLTTSTANEMFPT
                     NKGKITSIVMIASSIANYVILNIAGIITKSGGVNGPKYVVLFNVAITFVGILLALFVN
                     MRYEKEKVYDYDV"
     gene            complement(29593..30456)
                     /gene="aroE"
                     /locus_tag="KRO40_001008"
     CDS             complement(29593..30456)
                     /gene="aroE"
                     /locus_tag="KRO40_001008"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBH2091839.1"
                     /translation="MEISGRTGLFALIGTPVGHSKSPVMYNYSFKKLDLDYRYLAFDI
                     TVDKVKEALLAIKTFNIKGANVTMPCKSAVTEYMDELSPAARIIGACNTIVNDNGKLV
                     GHITDGVGYVRNLKENGVEVKGKKITIMGAGGAATAIQVQCALDGAREISIFNPKDDF
                     YKRAEQTVENIKKDVPECVVNLYDLEDTNKLYEEIQSSDILTNATLIGMKPYDNETNI
                     KDTSVLRKDLVVTDVVYNPKKTKMIEDAEANGCKAIGGLGMLLYQGAEAFNLYTGLEM
                     PVEEVNELCFK"
     gene            complement(30538..32460)
                     /locus_tag="KRO40_001009"
     CDS             complement(30538..32460)
                     /locus_tag="KRO40_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH2091840.1"
                     /translation="MKISSMFTPIRIGSMTVPNRFVVPPMGNNFANTDGTLSETSKAY
                     YLERALGGFGLITIESSVVDKKAKGGPRKPCLYDDSTIDSFKNVIDACHDAGSKVSIQ
                     LQHAGSEGNEKVAGHPLKAASAIPASNGRNTPLAITTEEIYELIESYGDAALRAQKAG
                     ADAVEVHCAHGYLVSSFISQRTNKRVDEFGGCFENRMRLPRLIIENIRKKVGNSLAIL
                     CRINSTDDVPGGIDVHDSSVIAAYLEDCGIDGLHVSRSIHIHDEYMWAPTTLHAGFSA
                     ELVTEIKKAVSIPVITVGRYTEPQFAELMVRQGRCDLVAFGRQSLADPEMPNKAKNGK
                     LDEMIPCIACLQGCVPNMFQGKPIACLANPILGHEAELKPAEISKEVLVVGGGVGGML
                     AAWVCAKRGHNVTLVEKSEVLGGQMRLAAYPPGKGDITNLVRSYISKCNQYGVKICTN
                     TEATVELIKEKSPDVVIIATGATPLVLPIPGINDSGLIHAVDLLDGKKSCGKKVLVVG
                     GGMVGCEVAAFLGEQEHEVTVIELREEVGADVISEHRKFLMNDFENYNIHTITGAKVS
                     KFYDDGVDYLLTDGTEHDLKGFDSVVLAMGSRNYDPLSEVIKEVVKETYIVGDAVKAR
                     RALDATKEAFEVALNI"
     gene            complement(32539..33387)
                     /locus_tag="KRO40_001010"
     CDS             complement(32539..33387)
                     /locus_tag="KRO40_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="HBH2091841.1"
                     /translation="MNNQKNLNIPITISSYTLGTEVSFRDRVRIAKEAGFDGIGLRAE
                     NYIDAKNAGVTDEEMIAILNEYDMKVTEVEYITQWGREEDRTEAQREKEQNVYHMAHL
                     FNVKHINCGLLEMIPEEQIITALGELCDRAGELIIGLEFMPYSGVPDLATAWRVVKGC
                     NRENAMLILDTWHWARAKQTAEDLAPVPADKIVSIQVCDVLETPYEKLRDESLHDRLA
                     PGEGYGNTEEFVKIIKEHNISPRVIGAEVISDSLISKGLSTAAETVFNATKKVLDKAW
                     SEVSPK"
     gene            33800..34681
                     /locus_tag="KRO40_001011"
     CDS             33800..34681
                     /locus_tag="KRO40_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2091842.1"
                     /translation="MNLYHLRYFVTLAHLEHYTKAAENLSITQPSLSHAISLLENELG
                     VALFEKEGRNIVLTKYGKIFLKDVEKSLEILDSSVKSLKITGTGEGQIDLAFLRTLGT
                     DFIPDIVHKFLKSNPAKSIDFKFHTGVTTDIIQGLKERKYDIAFCSKLEKEKGIEFIP
                     VAKQDLVLIVPYSHPLAAKDTIDLKETIPYPQIVFNQRSGLRYIIDDMFKKINQQPNI
                     VYEVEEDQVIAGLVAKNFGIAVVPNMNMLSFTKVKVIQIIHPSWERNFYLAFIKDRYL
                     PPAIKNFKNFVIKNAQL"
     gene            complement(34889..35752)
                     /locus_tag="KRO40_001012"
     CDS             complement(34889..35752)
                     /locus_tag="KRO40_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3800 domain-containing protein"
                     /protein_id="HBH2091843.1"
                     /translation="MLSSYVKRVSKIIKKKYIMFIDESGRADINHEDPFTLTGVIFEY
                     KYAVSQGDYVCSLRKEMDAFKEYCFGTSNIGIHLTDISRKSRAFEKFDDSQIKLFYDE
                     LPLFLSRLECTIISVTVDKARLKKYYAPSKEPYVVAFIHVLQNFYSFVNNETVESARI
                     VIESRDDVSNLKVQKAFFDVFNNGTIYLDIDEELRDKVKGFIIAKKEDADYREGLEIA
                     DILCNPLSRARRGLIEANPKCMQYGEKNKIFKSVRNKIYTPTSVNDIRNWGFKEVPIV
                     EPVGPWLEKMR"
     gene            complement(35907..37841)
                     /locus_tag="KRO40_001013"
     CDS             complement(35907..37841)
                     /locus_tag="KRO40_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp22"
                     /protein_id="HBH2091844.1"
                     /translation="MKKSLKKYLVLALTLVLVFACGVPESSAASKHVIIVNSRKNTLG
                     YFVNNKLVKEFRVATGKKGSETPTGKTKVVNKIKNRPYYKGNIPGGSPRNPLGDRWMG
                     LALKGTYGDTYGIHGNNNESSIGKHISGGCIRMHNKDVRWLFDQVPVGSDVIIDYSND
                     SYVKIAAKYKINLNQTGWKTENGKKYYVKSDGTYQKNSWLKVNGKMYYFDASGVMQTG
                     WKTINNKKYYLGTDGARVSGWKVIDGKTYYFNSDGVMQTGWQEKNGKKYYLGSDGLAV
                     TGWQEIDGNKYYFDKTGIMQTGWQQIDGKSYYLDKDGKMLTGSQKIDGKDYTFNEDGT
                     INPTWDTIIGANRFDTAKKISSVGNWNADSSDTVILVNGNAIADGITATPLASSYDST
                     ILLTNTANLPTETVEEMKLLAPKTVILIGGENAISSKLEQEIKTTFNTETKRIAGQDR
                     YQTATRIAEELGNREEIKTAYMVSGNGEADALSVASKAGEEKQPIILVNKDGITEESY
                     KWLTERKLENAYFIGGPSAINDSVIAKMNDITTEDISGNRIYGDSRVDTNAKVIEKFY
                     GDTDLQAVLVSKSDALVDALSAGPLAVKLHSPIVLMDNSGLSSEQQRVFANKKVETPY
                     QIGGGVSYIVMDKLMDILAK"
     gene            complement(37953..38966)
                     /gene="galE"
                     /locus_tag="KRO40_001014"
     CDS             complement(37953..38966)
                     /gene="galE"
                     /locus_tag="KRO40_001014"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HBH2091845.1"
                     /translation="MAVLVAGGAGYIGSHTAIELLESGYEVVIVDNLSNSNSIVVDRI
                     KELSKKPVKFYNIDIRNKDEMHVVFKENNIESIIHFAALKAVGESVEKPIEYYSNNLI
                     STLNLFELMREYGVKKFVFSSSATVYGDPHTCPILEDFPLSVTNPYGRTKLMIEQMLV
                     DISKADKSLDIALLRYFNPVGAHKSGRIGEEPNGVPSNLMPYITKIAVGKLKELSVYG
                     NDYPTHDGTGVRDYIHVLDLAAGHVKALQKLEENPGLVVYNLGTGKGYSVLDLVKAFS
                     KASGKEIPYKIVGRRAGDVAMCYADSSKAEKELGWKAKYELEEMCEDSWRWQSMNPNG
                     YEE"
     gene            complement(38990..39859)
                     /gene="galU"
                     /locus_tag="KRO40_001015"
     CDS             complement(38990..39859)
                     /gene="galU"
                     /locus_tag="KRO40_001015"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBH2091846.1"
                     /translation="MTVKKAIIPAAGLGTRFLPATKSQPKEMLPIVDKPTLQYIIEEA
                     IESGIEEILIITGRNKKSIEDHFDKSVELELELEQKGKTEMLEMVRDISNMVNIHYIR
                     QKEPKGLGHAIYCAKSFIGDEPFAVLLGDDIVDSDVPCLKQLIDTYNEYKTTVLGVQK
                     IAKEDTNKYGILDVKHIEDRVYKVKDMVEKPAIEEAPSDIAILGRYIITPAIFSILEK
                     QTPGKGGEIQLTDALQTLGKQEAIYAYNFEGRRYDVGDKIGFLEATIDFALKRENLKD
                     DLMDYMRKKVSEK"
     gene            complement(40057..40377)
                     /locus_tag="KRO40_001016"
     CDS             complement(40057..40377)
                     /locus_tag="KRO40_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091847.1"
                     /translation="MSSKYNVWTFNYEFLGLDSGDEKNNEVYYEIDLDEILNENYIDE
                     DIDSGLDSDGNSILGELISEMDIDEDVSVDMTYQELEVDLEDLDSYLDEDIDSDIKGI
                     LDEI"
     gene            complement(40367..42358)
                     /locus_tag="KRO40_001017"
     CDS             complement(40367..42358)
                     /locus_tag="KRO40_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091848.1"
                     /translation="MLKLGEKIIYELSDGFELSGISRYSKEYKKLHITNLGNIIISKS
                     DEVNKDTGVKYIYSFSDNKEKLEAVLEDSQIIIYGNNLPFYIKSENSSKNVTANLTMK
                     ITLDEYDLICKSQREFIFYLKDNMTILSLDDNKFYMGGINKDNEKFIFISGKNRFEIN
                     FDDIERYILEDKRVSLKGYFHMEREGIIVRSVSIFNNNIDSVVPSDLNERVKDNQKIG
                     NLPKDCEIVFCKISGNIDGFDYKNTNMLLVKYQDQLIFINKKSKKTIVKSAKDNCSKL
                     NLGEDIILYDNKNVFNLHINDKNREIMQIDDLKDIENEIVGYTLKHAPFFIQEDFDSL
                     TILKSFQKEIISIKNSDIKDIVINKELENENSNFVETEIKFNNQKVLLNLSKSMVQKL
                     MQDVFIYAKQPLLKENSIEVIYKNWSKAMNDMIIFNFFGNIYYMKSEFDKILEKELND
                     EIRIEVINSLYKQIQEQRNNLDLLSAYMPRILENQEIDLFEKYNTKLDVQVFKQIKNL
                     LSDLSYNISSYLNEVEKSLDNIIFVISGEDKKKYNYRMLKESESASLDVFLKQAISRL
                     NHLVENMYPYYVDETSREMFKLFELLWKNYRNIDDDSIKEILFERITNTYVFKQLTLN
                     NSTKERRKDIIEKIYNSVDYGTNKLDENMFFTGGIKYVK"
     gene            complement(42481..45024)
                     /locus_tag="KRO40_001018"
     CDS             complement(42481..45024)
                     /locus_tag="KRO40_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPOR domain-containing protein"
                     /protein_id="HBH2091849.1"
                     /translation="MKVLSENNIIRNTVLNVTASFLKQESKINEKLDGVLEKKFEKVE
                     FNEAKYAELLKFNILFYKTLARNTEPLIGKWIVDKYIPEIDELEKDLELTTAKCRKYV
                     NKAMKEGLDSLKANDLNSFLAYDKMELSERRRRLEKDYKVLNLYKDLLNISLRKISLE
                     KKECGDLFLKNQADAKRELKREIIFCVNKILASNKDVVPNNVEENNEQDKVEIKATEI
                     EDLQLGKDNSENDMLLNEIKNSKVKHESKSNDIESKFIDKLNSLNNESVSQTIHNEYK
                     KLCGLEELHSVEGYGFGKEIIKDFACATVVLEFLKRRNRDLIEGAMRLTIIGEFGPEN
                     FKEFVDYVIKNKTEISEDTWNKAQNLIKDNYSELENHEIASKRTRRNKDIDIEEYIYM
                     IKNADKDICFRSSISIEDDAEEGVKEEIDSNNQDIGDVVEDKDTTDKEYDSNKEDIIE
                     PENKKSKKKAKLFGFIKKDNEEVEQEEENLNDISPDIILDKPVENHQVKSEEIEQNEL
                     KEIKQEEPSQHIEEERNVKIEKPINNNLDEKVSSNNESKLEKESKNLEDKKAKEIKEE
                     KLENEKSVVIPIKKKENSNKKSKNSSKDKYRENKKEMKNYVSDKEDSLDDEEVVSKKS
                     RLKETIIAVVIVVIVGVGYFITVGNNKKNDKENIPKSSTQQQANNKLTEEEKKAQAEK
                     EKKEAEEKAKAEKEAQEKAQAEKKAKEMEAYKDGKGVYYTVYAGSLKVEKTAKETAKE
                     YEAKGISSTIIQENGYYKIKIGDYSQYGEAQEKCNELAKKSIDTYIAMYDKYYDYKLE
                     ELKESAPSLSAEELKQKYEDLRSELKNKSGYREYVKHLDKLYEEIVEGA"
     gene            complement(45302..45636)
                     /gene="rnpB"
                     /locus_tag="KRO40_001019"
     ncRNA           complement(45302..45636)
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="KRO40_001019"
                     /product="RNase P RNA component class A"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00010"
     gene            45768..46445
                     /gene="srtB"
                     /locus_tag="KRO40_001020"
     CDS             45768..46445
                     /gene="srtB"
                     /locus_tag="KRO40_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtB"
                     /protein_id="HBH2091850.1"
                     /translation="MKKLYRIVINIILVLVILYSGFNIYSKLTKYNHDTKISSELQKK
                     EYKKEDLSNINSDFKFWLSVENTNINYPVVQSKDNSYYLDKDFYKKDSISGTLFMDYR
                     NKSIDDKNIIIYGHNMKNKTMFNNLNKFKDADFFKKNNKIKITLNGKEFLYDVFSAYI
                     VESDYDYLKTNFNNESDYQNYINDITSKSLYKSPIKVNSNDKIVTLSTCTYEFDDARM
                     VIHGRLI"
     gene            complement(46605..46679)
                     /locus_tag="KRO40_001021"
     tRNA            complement(46605..46679)
                     /locus_tag="KRO40_001021"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(46645..46647),aa:Thr,seq:tgt)
BASE COUNT        15475 a         8035 c         5101 g        18150 t
ORIGIN      
        1 attacatttt ttataatacc cctttatttt ataaattaat ctaatcgatt aaatttatcc
       61 tatagaaatt tattacattt aaaaatatgc tagcaaataa aatatctact agcataaagt
      121 ctatttataa tattaatcaa ctattaattc tactaaatct ccatttttaa cgcctgctgc
      181 atttccctct tccatatcaa catgcatttc tagattaaag ctgtcactag ctcttactaa
      241 tacattttca aatactaatg ctcttggtcc agatgtttta acttttacta tttgcttatc
      301 agttacacca aatttagcag catcttcatt gctcatatgt atatgtctag aagcaactat
      361 aactccttct ttcatttcaa cttctccagc aggtcctact aatttaacac ctggagttcc
      421 agctatatca ccagattctt ttattggtgc ttttactcct aatgggaaac catctgctaa
      481 agatatttca acttgagtat gagctctagc tggtcctagt actctaactc cttttaaagt
      541 tccttttggt cctactaaat ccactttttc ttcacaggca tattgccctg gttgagataa
      601 tggtttaaat ttagttaact catgacctgc tccaaataat acgtctatat cagcttgact
      661 caaatgaaca tgtttattag ataatgctat tggtaatttc attgaaattc cctcctttta
      721 attatttaaa ttattgcaat acaattatac ataatattac ctacaaaatc aaattatatt
      781 gaatcaatat atatctttaa atttttatat attatatctt taaattcttg attatctata
      841 taagatacat catctgtatt gtttaaatat atattgtgta aaagtttagt atttatactc
      901 ttaaagaaaa aatccataac aatctgtcca cctttaaact gtgaatcata tgatttactc
      961 cctcccactg caatatacat tcctatccgt ttcttacttc tatcaattga aggtttattt
     1021 aatacatatt tacttgcata tatagcttga gttctatcaa caacagtctt taatttagct
     1081 gatattgaat caaaatgtac aggacttatt actatagttc cttttgaatc atcaaacatt
     1141 ttatataatg gcttcatatc atcattaaac ttgcaatacc ctgttttttc acaaaatcca
     1201 catgctgtgc aatattcaat atccatattg tagatattaa atattttaca acttaatcca
     1261 cactcttcta gcatagcttt tacttcattt gctataaaac tgcaattttt attaattctt
     1321 ggacttccat ttattattat aatctctgga cttttaagtc cttttttatc gtttgaatcc
     1381 ataatcaatc tacctatcct ttaacataac tattaaaata tcatcatcat aattatcttt
     1441 tgatgagaag ttctttaaat ccaattttag attttctact attaactgtt gatttaatct
     1501 aaaattttct tttagaaagt tttctaatcg gtttatacca tactcttctt ttgatgaatt
     1561 ttttatctct aaaattccat cagtgtacat acataccatt gcataatctt ccattgaaag
     1621 agtattattt tcataagtag catcttccat tattccaata ggtatgccct ttttacaatt
     1681 taaattattt tctattgtgc catctttctt tacaactaca ggactatagt gacctgcatt
     1741 agacacagta atcatatttt ctttagtatc tataatacct atcaaacaag ttgtaaatac
     1801 tcccatcttg tcaaattcat catataacat cctatttaaa tttgtcatta tttctcttgg
     1861 tgtattgtat tgattacata atactttaaa agcacctttt atcattgcaa caacataatt
     1921 tgataccatt ccatgtccca ttacatcagc aacaatataa actatatgtt catcatccac
     1981 ttttgtagca taataaaaat ctccacctac tacccttgct ggtttatggt aaaaataaag
     2041 ttctttctca tcattacaat ccattttacc tttatccata ataagctgtt gttgtttatt
     2101 taatatgttc aactcgtttt caagaacttt gtgttttact tccttttcat tatgttcata
     2161 taattgcata ccaacagaaa cttgtttgga caatatacta agaatattta aatcatcact
     2221 agtatagttt ttgctatttg cacaaactat acatcctata gtatcatttt tatcctgaag
     2281 tttgtaatat atataacttt ccaaatttat tccctttttt gagcatggtt ttaaattatt
     2341 tagatacccc cccaatgact ctttctttaa aaacatatca atcataggat ataaatttgt
     2401 tttctttttt tgctcaacat tataacaact aactatagca tccttattat gatgactatt
     2461 tataattatt aaagcttctt tactattagt aatattacac gcttgtttac ttaaattttc
     2521 caaaaagcca tcaatactct tattaaggta tagtttttta gtagcttcat ttatggcact
     2581 tattgagcct cttagtttat caattaaaat ttgtacatta ttatttttat tagttatttc
     2641 tattgataaa cttaagagtg atgcaacaga tgatataaaa tctatatctt gttctgttat
     2701 ataatcatcc tcttttaaaa aacaagtcat aaatccaaca actacgttat ttattataaa
     2761 aggaaaaact attctcccaa tataaccttc agcttttgct aaatctcgtt caccttctgc
     2821 tctagaatct tcaaatacat tttccacata tattatcttt ttttcattta cagcctcatg
     2881 tatatactct ggatatgtgt caaaatcaat ttttgcacct ttaagactat ttattggaaa
     2941 aatttgaggt acatattcta aggtttgcga acatactaag taggcatatt tagaatcatt
     3001 tttataaaat agattcacac atgcctttgt agggtgaaca acttctaaca ttttttctat
     3061 tatgtcatct tttatattaa aaaaatctgt agattcagtc accatagcgg atatttccac
     3121 taaattcttc attttataac tgccattagt catactcaat ttctccccct atatattaaa
     3181 ctatttatta gtattttaac atacattctt tatagtaaaa acaaaaacaa cgacaaaact
     3241 agcaactaat atccagttaa atcctgtcaa taatcctata agaagtaatg taattaatgc
     3301 atttagacct gttctccctt tttcatccat aaaagttatt ttagagatgt cgatattatt
     3361 tttcacatta tttatatgtt cttttacttg ttcttccata tttcttttat atagtatata
     3421 aactacacca actaaaaaca ctcctatacc taaaaccatg tttaaattaa aagctaccat
     3481 aagcaatatt gaaccaaaag ctaactttaa aagcttaaaa aatacactat ctatctttag
     3541 agttatattt ctgatttctt tacattcatc tcttaaagaa tatccacttg aatctaagtt
     3601 attaatcttt gtttttacaa tttcagaata aaaaagcttt attatcccat ttaacatttt
     3661 catcactcct aaatatttta catatatttg taagttttac aattataata ttttttatac
     3721 ttggtaataa taaaaaataa caaatatttt atgatttagt atttattgta aataagttat
     3781 tgaagcttta ttagttaagt atagattttt aataaatatt tttataatta gaaggaagtg
     3841 gttttgtgca aatagaacaa ctcgatttag aaacgagaaa taaaatatac tgctatacta
     3901 aaaaaattct tagaaaatat caaaaaggca taacatctgg aaaattaaca gcagataaat
     3961 ttgcagataa tatattgtct caagatttta tcagtagtat acttaatgaa aaaatagtca
     4021 atgagacaaa ctttaagata tcttatagaa actatataga aactttaata aatattcaaa
     4081 atgaaaattt atctaactta agaaaaaaat ctactaaaac tgcaaaatgt ttcaatatct
     4141 ctcaaataac ccaattaaaa aacttactaa gtaatactgg ttataattta ttaattccat
     4201 ataaatactt aactgctaga gatatagaag gaatagttac tcttattaat actgggtcta
     4261 ttgaacttgg aaatgagaga atctataatt atatatcaaa agcataataa tttaaaccta
     4321 ttataaaaag gcaatttatt taataaaaaa tatttttaat attaaataaa ttgccttttt
     4381 aattttggat taaatactgc tatccaagtg ctttttctag tttagataaa tgttgtattg
     4441 gataatattt tagtagctct ttaaattgtt ctactgataa accttctgtt gttgtatata
     4501 ttcttatttt ttcatctaag tcactattaa taaatttgtt ttttaaatcc tcaaaattta
     4561 cactactcat tttacatcac tccttatgta acatattcat ttgtattatt ttatccaaat
     4621 acataaaatt tattacataa aaatatatct atttaataat ttaataaaaa aaagctatct
     4681 caatttagaa attactttct atatttgaga tagctctagc taaactaata gccaatagtt
     4741 ataaataatt atttataact atctgttgct ttttccagcc atttgttgtt cagccatttc
     4801 aactaatttt ttagtcatgt atccacctac ataaccattt tctcttgcag taaggtttcc
     4861 tttatcaact tgttgataat tactcatacc aagttcatta gctatttcta atttcatttg
     4921 gtttaaagcc tcttttgctc ctggtactac tgttctgttg ttgttattgt tacttgccat
     4981 gttgattacc ttccttctgt ttaatttatt ttgtgttgct gataatatta tgtgatttta
     5041 aacattttta attcaggtaa tttttagcaa ttaaaacctg ccaaatatcc agtagaaaaa
     5101 gctatttgca aattgaatcc acctgtatat gcatctatat ctattacttc tccagcaaaa
     5161 aataaacctt ctactaattt tgattccatt gtacttgaat ttatttcgtt tacttttaca
     5221 ccaccagaag ttattatagc ttcttcaata ggtctgtatc tctttactgt aaactttaaa
     5281 ttttttaata aatggactaa gttttttctc tgctctctag aaatttggtg aacaaccgta
     5341 tttggattaa tttcacttaa gtttattatt ataggtatta gtttttttgg aagtaaatca
     5401 tctaatgctt tttcaaattt tttatttgta tacttctgaa aatctttttg aactctttta
     5461 tccaattttt cctcatctaa tgcaggtttt aaatctaata atatagtgta attttctttc
     5521 cttgtatctt tcattctaca acttgcagac ttgattatag gtccatctaa accaaattta
     5581 gtaaattcaa gttctccaaa atcactataa actttctttt gtttgctatt aaacaccctt
     5641 atttcaacat ttctcaatga taatttttct aaatcttttg taaaactttc ttgtacttct
     5701 ataccaatta aagatggttt tgtatctata attgtgtgcc cctgtgaaat tgcaaattta
     5761 tatccatcac cagtagaacc agtaagtgga taacttaatc caccagttgc tactacaact
     5821 gaatcacact taatttcttt tttatcgttt aaaattactt tttcaatttt attattttta
     5881 gatattattt tttctacttt cgaatttaat aatatattta ctttcttact tttaagttgt
     5941 ctttcaagag catttacaat atcaaatgct ttatcactct ctggaaaaac cctttttcct
     6001 ctttctgttt tagtctttac tccaagatta ttaaacatac ttattacatc atcatttgta
     6061 aaagtataaa aagcactata aagaaatttt ccatttgtag gtacattttc tattaattcc
     6121 tctatttcac aagcgttagt aatattacat ctaccttttc ctgttattgc aagttttttt
     6181 cctaatttat gatttttctc aattaatgtt acatcatagc ctttctcaca tgcagttgat
     6241 gcggctatca tccctgctgg tccaccacct attattacta ccttcttcaa ataatcactc
     6301 ttttctaccc ttaatttttt taatttaaac tattgactct ataccttaaa atcaatttaa
     6361 ttttaaaagt ttaaataatg ctggagctcc tgctattcca taaaaaacaa ctactgtatt
     6421 cttaataaaa ttcataaaaa ttatactcat agtagagtca cttatattta aagtgactat
     6481 taacattgaa ataaacaact taatgccaat atataacatt cctattgtta ctatcccaac
     6541 caaaaaccta catattcttg aaaaaattat atttttactc cccttatttt tattactaaa
     6601 atttattttt ttgttattat tatctgtatt aaatttaaca aatctatcct caaccatata
     6661 tccaaataca aatcctacta ttataccaaa tttttcaaaa tattcagggc tatttagaaa
     6721 tatagccact attataaatg gtataagtaa aactacaagt aaaatataat ttttattatc
     6781 atcaatatag tcaaatattt ttacaaatac aactgtaaaa aatattccta atatccaacc
     6841 cgctatcaca tctattggcc aatgaacagc taaatacagc ctagacaatc ctactcctaa
     6901 aaccataact gcacctatta aatgaagata tctcttttta aatatagtca taatactaac
     6961 ccaaaatgtt gttgcagttt gagtatgagc acttggaaaa gaataaccac cagcagtaga
     7021 aactctcaat gattcaagac cttttattcc tattggtctg ggagctttta caaactcttt
     7081 gatgcctaaa tttacaacaa aatttccaat tatagcaaac agtattttct gtccacattt
     7141 tttatttata caccagtata taattgttgt aattaatatt aataacggtg cttctgtgct
     7201 tattgtaaag acaagaaata taaagttcaa aattggattt cttaaatttt ggaaaaataa
     7261 taatatattt aactgaatat ccatatagat gtctccttta ctaaaatttt atataattaa
     7321 ctaaaaagca ctaactccct tagaaattag tgcttttgat tcacatttaa atctattcta
     7381 catcctcaac tatacctata taaggtaaat ttctatactt ttcagcatag tctattccat
     7441 aaccaacaat aaatttgtct tctataacaa atccaacata gtctacaggt atattagctt
     7501 ttcttctctg aggtttgtca agtagagtac atagttttaa agattttgga tttctagttt
     7561 ttaaagctgc aactagatta cttaatgtta aaccagaatc tattatatcc tctacaatca
     7621 acacattctt tccttcaata tctacatcta aatcttttaa tattttaact gttccagaag
     7681 actctgttga gtttccataa cttgtaacac tcataaaatc tatatttaca tccaaatcta
     7741 tacatcttat taaatctgaa acaaatacac tagctccttt aagtatacct accactagta
     7801 aatcttcgcc tttaaagtct tcttctatct tttttcctaa ttcataaact ttttctttta
     7861 tttgttcttc tgtcaacatt tttcctgtaa ctttgtacat tttgtatcct cccgctttcc
     7921 ttctattaac ttatatatta tagcatacca aaatatcaat taaaatcttt ttcatcattt
     7981 ttaaacctaa attaacagct tatccatact tttttgcttt ttccattaaa aatttggaat
     8041 aacgattcct ttgtattata atctatatgt acatatatta atcagttatt tttatcgatt
     8101 atataatttt atttttggag gtacttttat gagcacaaac catggagcta atttatatag
     8161 tttatctagt aagtatggct tttcaaagga agaatttatg gattttagct caaatataaa
     8221 tccttttggt acatcaagtt tagccaaaca atacattgta aacaatatag atatggtatc
     8281 tatgtatcct gaccctgatt acatagactt aaaaacttct atatccaatt actgcaaatg
     8341 ttctatagat aatatagtac ttggcagtgg agctacagaa ctaatttcat catttataca
     8401 tacaattaac cctaaacagg ctcttttact ctctccagcc tattcagagt atgaaaaaga
     8461 gttatctaaa attaattgtt ctatagaaaa atactttgca aaagaagaag ataattttca
     8521 tataaattta gaaaatctta taaaaactat caatgctaaa gattatgatt tggtagtaat
     8581 ctgtaatcct agtaatccaa ctggatttgc atttactaaa gtagaagtga gagaaatttt
     8641 aaaaaataca gactcatttt taatgattga tgagacttat gtagagttta ctgatacaga
     8701 tacatactct tgtactcaat tagttgatga ttattctaat ttattcgtta taagaggtac
     8761 atcaaaattt ttttcaacgc ctggaataag gcttggatat ggtcttatat ctaacactaa
     8821 tgtcaaaaat gaaataaata aaaatctaga tttatggaat ataaacataa tagcttctaa
     8881 aatgggtgaa atcatgttta gtgatttaga ttttatatca aatactattt ccttaatgaa
     8941 cactgaaaga gattacctgc ttaaagagct taagaatata aaaagcttag atatatacaa
     9001 tactaaaggc aatttcatat tgtgtaaaat caagacaaag gaattgactg ctaaatctct
     9061 tcgagaacaa ttgcttccac aaaaaataat aataagagat tgttgttcat ttgaaggtct
     9121 agatgagtat ttctttagag tatgtatatt aaaacctaat gaaaataaat tattaatatc
     9181 atctcttaaa gcaattttta aataaaaaaa tcactttatt ttataatttt ttataccata
     9241 aaaaatgagc tatctctatt tgagataact catttttgat tattaaaaaa ctaagcactt
     9301 tgctcttctt tatttccttt tttactcatt ccatcattta ttttatctac tactactgct
     9361 attgcattat ctcctgatac attacatgct gtaccaaaac tgtcttgagt taagtataaa
     9421 gctatcatta aacttgcaag cccaccatct gatggtattc caaccattgg taggaaagga
     9481 agtgcactca ttatagcccc acctggtgct cctggtgctg caaccattgc tatacctaac
     9541 attgcaatat aagggaataa tacacctatt ccatgtggca taccattcat cattaaaact
     9601 gcagttgtaa atcctgttat tgatatcata ctacctgata aatgtattgt tgcacaaaga
     9661 ggtacaacaa attctcttat ttgcttactt actccatttt tttctgcaca accaacatta
     9721 actggtatag ttgctgctga agattgagtt cctatagctg ttaaatatcc aggtacttga
     9781 ttttttaaca ttcttactgg attttttcct gaaaatacac ctgctgctgt gaattgacat
     9841 gccatatata caaaatgtaa aggtattact actaagtata ctttccagaa tacccctaat
     9901 attgtccata cttcccctgc tatagttata tttgcaaaag ttcctgctat gtataaaggt
     9961 aataaaggta taatcactgt tgacaacgtt ttcgttacga ttccttgaaa ttcttggaag
    10021 aaattaaata aagtctctcc ttttccatga tttcttaaag ctgatattcc aagtcccatt
    10081 acaaatgcaa atacgattgc agctgttaca tctaccatag gctctaatgg aattgtgaat
    10141 attggagcta acattcctgc ctctgggtct ccaatttgac ttgcaacact tgcatcaata
    10201 aaatttggga agattaatgt agatactgca aatgataata atcctgctat taaggtagaa
    10261 ccatatgcta ttcccgtagt tatccccaat aactttcctg cacctgttgc taaatcagct
    10321 atacctgctg ttacaaaacc tataattata aatggtataa caaattttag gaatgctgag
    10381 aataaagtac taactgttac taatatttgt actattattt ctggtgcata acttccgatt
    10441 aaaataccga ctatgatacc gatgattagt ttgggcacta aacctatttt tttcttcata
    10501 atatttaccc tccataactt ttttaaatta agcattcttg cacattgaat acttagttaa
    10561 atattggata tccacttatt atgataatag agttttacct ctccgtcaac aatttaacca
    10621 ttttttgtta ataaaaaaaa gaataacata tataaattgt tattcttctt catcttttat
    10681 agaaaattct acattttcaa ttatatttga atgtttatct ttttttgcga taactctata
    10741 cttattaatt tcttcattca ctatacctat actccaaatt aaaactatag catcatctat
    10801 aaaaccaaat gcccctgcaa tcatctctgg aattatatca accccagata caaagtagga
    10861 tatagtaaaa attaatacag aaattacctt tattttatca actatattga ttcttttatc
    10921 tgtcataaaa tcaggtagtt taagtaaatc aaatacaaaa accaaaccaa atttagcatt
    10981 tttaaatctg accaaaattt tttttaaaat atctaaaact atattaatga ttatttttaa
    11041 aaactccata tttatcacct cttataatta taggttattc tacattataa ccgatataat
    11101 taatttgatg aacatattag atataaattt tatcaattag tttatattta aattataata
    11161 attcaattcc tgcactacta caattttgaa tcatatcctg tggccatact ccaacttgta
    11221 cttctcctat atgagctttt tgtaagaaat acatacatat tcttgactga ccaattcctc
    11281 caccaattgt atacggaagt tcgccattta aaagcatctt atgatagtca aactcttttc
    11341 tctcttcaca tccagcaagt ttcaattgtc tatcaagaga ttcttcatca actctaattc
    11401 ccattgaaga taattctaat gctgaatcta aaacaggatt gtaaaataat atatccccat
    11461 tcaattccca atcatcataa tcagggcttc ttccatcatg tttttctcct gatattaatg
    11521 tttttcctat ttgagttata aatactgctt tcttctcttt tacaatttta tcttctcttt
    11581 cctttggtga taattctgga tacatatctt ctaactcttg tgatgttata aaagttattt
    11641 cttctggtaa tatttctttt ataccttcat acatactaca tacaaaaatt tcagtatctt
    11701 taaatactcc atacaatctt tttacaacat cttttagagt cttttcattt ctactacttt
    11761 tatctataac caattcccaa tcccattggt ctacataaag agaatgtata ttgtctaatt
    11821 cttcattttt tcttattgca ttcatatctg tatataaacc actaccaact tcaaacccat
    11881 attttttaag ggctaatctt ttccattttg caagtgattg aacaatttct gcatttttat
    11941 tcataaatgg tatatcaaag cttacagcct tttctccatt taaattatca tttgcacctg
    12001 tttctggcaa tacaaataac ggagaagaaa ctcttataag atttaattca ttacttagtc
    12061 tcatttcaaa aaaatctttt aattttttta tagctatttg tgtatcaatt acgttcaaac
    12121 tacttttata atcctttggt attattgtgc tcatatcatt cactccctat atttatatat
    12181 ttttccatta aaaaaaccct tcatccctat ataaaaggga cgaaaggttg cttttccgcg
    12241 gtaccaccct gattagtttg aaataaattc aaacccagct cacaatgtac agatattact
    12301 cgatacaccc caatatgata acggtttggt tccgactaag cctactcttt taaaatttcg
    12361 gttagcaact ccaggatgtt cttcattata gacttcatat tggtctcaca ccatcaccaa
    12421 ctcgctttaa ttacattcta taactactct tcctttcaaa gtctttaaga gtttaattca
    12481 ataaaattta gctctcttat gttttctatt tattcataat agtatgataa gtgattagtt
    12541 aaaatttgtc aagtttatta tttttttatt tttaaacact ttataaattt ttacctatac
    12601 tttataaatt ttcaaatata gtctttaatc tgtccataca ttcttttaat aaagactgtg
    12661 gacaagctac atttattctt tcaaatccta ttccttcttt tccaaatata taaccttcat
    12721 caaataatac attagctttt ttaaacatta aatcttcaag ttctacttca tttaatccat
    12781 aagcagtaaa atctaaccat gctagatatg ttccttctgg ataaacaagt tttacttttg
    12841 gtaggttttc ttttaagtat tcatcaataa attgtatatt attatctaag taatcattta
    12901 attcattaag ccagtcttca ctttcattat atgctgctat tgtagctaca atagcaaagg
    12961 gatttggtga agttgcaact ccaacagctg taacctcttc ttgatatttc ttttttagtt
    13021 catcattatt cactattata ttagacaact gcattcctgc cagattaaat gttttacttg
    13081 gagctataca tgtaactatt ttatccttgt actctgggca taatgactgt aaaggagtat
    13141 gtttaaatcc ttttctaatt aaatcagaat gtatctcatc agctattatc cataggtcat
    13201 attttttaca tatttctaca acctttttta attcatcttc tctccaaact cttccaacag
    13261 ggttgtgagg actacaaagt atcagtactt tattgttgct acacttagct ttttcttcta
    13321 aatcatcata atccatccta taagtaccat tctcatatat cagaggattg tttacaacat
    13381 ccctattatt gctctttatc ttagcttcaa atgggtaata cactggtttt tggactatta
    13441 caccttcatt agaattagtt aatattctta ctaaaatagc aacagcaggt acaacaccag
    13501 gactaaaaat aatatctttt ctatttattt cccagttaaa tctcctttta taccaatcac
    13561 aaactgcatt aaagtattta tcactatcat ttgaactata tccaaatatt ttatgttcaa
    13621 cttttttacg taatgcttct attattggtt ctgcacattc aaaatccata tcagcaatcc
    13681 aaaaaggcaa accatctttt tgtgcttttg ttgaacaatt agttctaaaa tcccatttta
    13741 cacaatctgt tcctactcta tctattactc tgtcaaaatt atacttactc attttttccc
    13801 tcctaagaat aaaattttta taattgttaa gtctattact agatgcactt tggtattatt
    13861 ttacaattct taatattata ataatatcac ttttttgtcc aatagattta aaatataatt
    13921 acttttccat catatttttt caatattcca aaatcagttt cattatatca aaataagatt
    13981 gctcatatta attattttct aattaacata agcaatcttt ttctataact tctataatta
    14041 taattttaaa tgtagaatta ttagtttgga tgttatccca atctcttttc aaccaatcta
    14101 caccatatat ctacaccata ttctaaagct ttcgtatcaa atgttacatt tggattatga
    14161 aatcctggtg tagcatcagc tcctaatcca atatatgtag ttttacattt tagtttttgt
    14221 gtataataat ggaaatcttc tccaccagaa tttttaaata tacctataga tgcatcagct
    14281 cccaatacat cttttatagt ttcttcagcc aagtttacaa gttcttcatc aaattctgct
    14341 gctggtactc catctttgga aattagtaca gcttctgcat ttatagaact tacagcagtt
    14401 tttacagcat gtattgcttt ttcttttaat tcttctatta tatcattact ttctgccctt
    14461 atatctaaag ccataaatgc ttcatctggt atattattat aagtttctcc cttaactgat
    14521 atatttgtta cttttataga atttggtata gctggattta ctcttattgc atttattgca
    14581 ttcactgcta aacagacagc atctactgca tttactccta aatgtggttt agaaccatga
    14641 caagtgatac ctttaatcgt aaattccatt atacagctag cacaatggta cattgcaggt
    14701 atcgcctttc ccaacctaca atcttgtcca ggtcttaaat gcatccctac catttcttct
    14761 acatcatcca acaaaccaga atcaattact cttaatgctc catataattt ttcttcacct
    14821 ggttgaaaaa gtatttttaa cttacctctt tttactaaat ttctctcttt tattaacttt
    14881 gcagctgtta aaagcataga agtatgacca tcatgaccac aagcatgtat cattttcttt
    14941 tctccatcta tgataaattc caatgcatcc atatctgctc ttatagcaaa tactggtcct
    15001 tcttttttag aatctatagt tactataata ccagttcctg caattccttt attaatattt
    15061 tcaaacccca ttttttcaag ctcttttaaa acaaactctg atgtcttata ttcttcaaat
    15121 cctttttctg gtatagtgtg tagataatca tacactttat gtacatactc aatatagtct
    15181 ttgttagttt ccataatcta gctcctcctt aaaatttaaa ctttccattt atattaaatc
    15241 tttattataa ttacctatac tacgaaataa ttcattataa gcattgcaat acaaccattt
    15301 aaagttgcta taacaaacat atgtggataa tatttagttt ttaactcagc tgttcctaaa
    15361 agtctcccca taaattgtat ctgcgctcct gaaagcaata acattggcaa tagaattgca
    15421 acatgtgctt gacttatttg acctgctgta aataaacctg cgattactcc agatgctcct
    15481 cccattgata taaatattgt cattatagct gttgctgcaa cacctggaag tccaaagata
    15541 ctcattacag gtgtaaatat tgtccctatt acatccaaaa gacctgttaa attgaacaca
    15601 gaaattatag caaaaccgaa gatgacattt ggagccattg aatttgtact tatttggaat
    15661 ccatttctag ctcctccaat aaacgcatct atcacatttc cttttttaac ttttacttct
    15721 ttttttgcta cctcactcat gttaagcttc ccccttgtca aatttattta aatataatct
    15781 aagtaagttc gccccaacaa acttcataat taatattaaa gcaagtggta taaatattgg
    15841 tacatctcct ataaatggaa atagtgctgc tccagaagca aagaaattcg taattgcaga
    15901 cgcacctgaa aattgaaatg cacaaaatac agctttttgt ttttcatcta tatacccatc
    15961 atctttaagt tctttagtca tagatgcagc tgcatctgta gactgtaaac tagctatcaa
    16021 agttagtcct gcaaatccag gtaaccctaa taatggcttt aatagtggac taagaagctt
    16081 ttgagctgcc ttcattccat ctaagtggtc tataactcta actactccaa gtgcaaacat
    16141 aactgatggt attaatgtca atgcatatag ccatccatct cgagggccag tacctccatc
    16201 acctctaaag tttgcagcta atgtacctac accatcatta attgttccca atgttccaaa
    16261 agaacctaat acattgttaa aatccaatac ttttaatggt cctggtgcat ctttaaatat
    16321 tcctgaaaaa aataatgctc ccaatattaa tgctacatac ccataccatt ttacctcaac
    16381 tttttctgtt gttgattcta atttactcat ataaattctc cctcctgttt aaatgaattt
    16441 tattagtata cttgtttaat aagcaaaact tatgccaata ccttaatgat aaagcctttg
    16501 tatttatttt tttattgtaa atttattcca gtgattaaat agcttataat tacttacttt
    16561 tcaagtttaa aaatataata tttttttatt aattatttaa aatatacatt acaatataaa
    16621 aagctatttt ccttatcttg caaaaataat tttaaaatag gtttttatag gataaaatcc
    16681 taaaaaaacc tattatttaa tcaaatatat aaatttatac tactatttgt tgtataatat
    16741 aacttgcctt atactttaaa tactttaaaa ataaatacta ttttgttagg agaaataaaa
    16801 tggataaaaa gaagttaatc cttataacac atgataaatt gaatagtgac cactacaaag
    16861 aagaattaac aaactttttt ggagacgaaa taatcataga aacacaaaat atacttgatg
    16921 gaataaaaga aaatttagag ggagatgtag tgctttctct atcaccttta actagtaatt
    16981 ttttaataaa acattttaag gaagatattg aaattattca tggaacgaaa gcactttcaa
    17041 aacttggata tgaaaaaatg atgaaactac ctccaggtac aaaatcgtta cttatgacaa
    17101 ccaataaaac ttcagcattt gagatggcta cttatctata taaaattggt ataaatcata
    17161 tagattttgt accgacatat ccagattgtg atgaaatata tgatttagat acagctataa
    17221 caccaggtca gattagattt ataccaaaat acataaaaaa tattgttgat ttaggttgga
    17281 gaaaaatctc attagataca tatatgtcat tattagtagt attaaaacta aaaaatgaga
    17341 aatttataga aaaactatac aaattgtcca aagagacact aagtcatgat ttcttaaata
    17401 catcattaga taatatatct aaattaaaaa ctatacttta catgaccatt gatgaaatag
    17461 gtgatggtct aatatttttc aacaccttta acaaggttac ttttgtaaat aagtctttac
    17521 ttaatatgtt gggactagat gaaaaactta taaaatcacc ttccttaatg gaatatatgc
    17581 caaatagttt cttagataaa attacaaaga acttaaatat cgataatatg attatataca
    17641 tagacgaaat agataaaaaa ttcatacttt ctaaaaaacc attttatctt tataaaaata
    17701 tagagggttg cttaattaca ttgaaagatg taaacaatat agaaatatta gaacaaaaaa
    17761 taagaagtga ttctgtcaaa agaggttatg tagctaaata taaatttaat aatattattg
    17821 gaaatagttc tattataaaa gattgtatta aaaaggcaaa aaaaatggct cttacagata
    17881 atcctatatt aataacaggt gaaacaggaa caggtaaaga agcctttact cagtcaatac
    17941 acaatcattc aaatagaaaa aataaacctt ttgtagcaat aaattgtgct tcattaccaa
    18001 gtgaattact tgaaagtgaa ctatttggat atgaagatgg ttcttttact ggagcaaaaa
    18061 aaggtggaaa aaaaggatta ttcgaattag ctcacactgg cactatattt ttagatgaga
    18121 taggagatat gccacatgat ttacaggtta aacttttaag agtcttacaa gaaaaagaaa
    18181 ttagaaaaat tggtggtaca agtattattc caattgatgt gagaatatta gctgccacaa
    18241 ataaagattt agagaaatta attatagaaa ataaatttag gatggattta ttttatagga
    18301 taagtatgtt cactttagat ttacctcctc ttagaaagag attagaagat atacctcttc
    18361 ttttagaatc atttttaaaa gaacttccct ataaaaacat aaaactcgat aagagtcttt
    18421 tagaagcttt aaattcatac acttggatgg ggaatattag agaactgaga aattgtattg
    18481 aatatatggc ttacatgggt tccaattatc ttacaataaa tgatttacct caaaacatat
    18541 cttcaaaatt aaataataat catatgtcaa gtaatatgtc catattcaat gatttaaacc
    18601 aatatgacaa aaacatatgc atttctatcc taaaatcatt gcacatgaaa ccaatgggga
    18661 ggacaaagtt aatgaaattt atggaatata atgtcacaga atacgaagta agaaatatgc
    18721 tagaatattt gacacgcaat ggatacttaa tttctagtaa aggaagaaaa ggctcatcaa
    18781 taactgagaa aggcataaaa ataatagaaa ataatataat ttaaacctat agtaattcat
    18841 ctttacttta tcaaaattta tatataatta taatttttta tttttctata aattttttat
    18901 aaaataataa aacttattta tattaaaaac gaagctatct caatataggg ataagcttct
    18961 ttttaattgt taaaaagata aaaatatatt tgatttaata gaaaaagagt gcctcataaa
    19021 ctaaaaagtt cattttgaga cacttcctta atattaataa attaattggc ttaaaattac
    19081 tgattgataa ttataaagta cctctgttaa aggagtaaat tctgaaccga ttccaaatct
    19141 taattctgta aacgcctcta aataatctgg gtcacataca tcttcttgtg ttaaatcttg
    19201 tttcaccatt tcagtagcaa gataaattgc tactgatggt agaaaagcat ccattggcat
    19261 aggatatcca ccaagtctat ttgacatgcc aaaagcctta gccttttcac ttatcatgtc
    19321 gtttatttta tcataatttt gagcatcttt ttcagatatt tttagaccca taacactagg
    19381 atatgtttgt attggtgatg gattgctttg ctctgcaact atatacttta attctaaagc
    19441 cttagtcaat ataacttcat ccatatactc atttacacca aatacattta tatcttttcc
    19501 atatttttta acttgttttt caatatcttc atttaaaaac tgcttaactt tgtttttgtc
    19561 ttcttcagta tttatatttg gagtattaac ttgtacaaat ggcaatccta tatttttgca
    19621 agtctcttta atcatttcta atcttttggc tatattaaca tctttcaaat catctgtaga
    19681 ggcataatga ataaaagctt ttgctcccat ttcttttgaa cgttcagcta atacttttcc
    19741 tctttcctct gcactaaccc ctagattcac atcaacaaat tggcttaatt ggtttttatc
    19801 atctcccata ggggcagaaa tagttattat ttctggacgc ttttccttta ccttttgtaa
    19861 agcaggtaaa agccctgctt ggtcagttga aactacaata gcctgaactt ctttatcgtc
    19921 agccaacttt actatcttat taatagcact gtctatatta gaagtaaaat tctctggcaa
    19981 tacaacatgc tttatagttt gtttaacttt agtttgacca tctttgtctt tatcaatttt
    20041 attctcttcc tcatattctt ttgccatctc ttccaccata ttgtattgta ctttattttc
    20101 agataatggt tgagttacca ctgcaacttt aaaatcatct ataattttct ctttatcttt
    20161 cttgcctaca agtaaactac aacctgtaag tccaataatt aaacatatgg atagcataaa
    20221 tgctgttatt tttctaagca ttaattaaaa cctcctaaat ttgtacattc ttatcactat
    20281 tactaatttt atcatacttc aaagaaaaat tatattataa aaaattatat acatgctatt
    20341 ataatccaat ctaaaaagta ctatgggtag attaggttta gattaaacct acccatagta
    20401 ctaaaaatta atatattata aaattaaatt aattacaaat tattatgcta cttgtttgtt
    20461 gctttttata aagttaccaa ctattccacc caatatagct ggtattaccc agttaaagcc
    20521 caaacctgca agtggcaagc tttgtataaa tggaacagct cctgtcattc catttatagc
    20581 tgataataaa ctaatcacta atgtaacata tgctgcacct ttaaaagcat tatcattctt
    20641 tatatgttta ccagccaact ccataacaac tattgctaat aaaacaggat atatagtttg
    20701 taggattgga actgatatgg ctattataga atcaacacct aaatttgata taagcatact
    20761 agctacacat atacctataa ccagttgttt ataactcgcc ttacttattc cttcaaaata
    20821 agttgatatt gatgctgtta aacctgtaga agtagtcaga caggcaagtg ccacaattac
    20881 acctaaaatt acctttccta cttgaccata taacaatata ctagttattt caactaataa
    20941 agatgcttga ggtatactag tatcatataa agttgaaact gttgcaccta aataagtaag
    21001 accaccatat actactgcta gaaatacaca ggctacaaaa ccagctttaa tagtcattcc
    21061 tatttggtct ttatctgatg tatatccttt agctattata gacatcaaca ttatagttgc
    21121 catagatgct gcacctagag cgtccattgt ttgataacct tgtgatatac cttcaccaaa
    21181 tagattttta tctatcatat gctcaggact cataggtcct gctggagaaa ttataccctt
    21241 tactattaaa acaaataata ctaataataa cgctggagtt aaatacttac ctattatgtc
    21301 tataacctta gaagacctaa tagtaaatgc taaagttagc ccaaagaaga ttattgaaaa
    21361 tacagcttta gctactggac catggtctcc aaatataggc ataataccca tttcatatgt
    21421 tgttgcgcaa gttcttggta ttacaagaag tgctaaacat gctagagcag ctacactcat
    21481 tactcttgct aaccctttac cagctctcct aagtacatca tccatgcttc ccttacatct
    21541 tgctgttgct ataataacaa gcattgctat accagcatct gcaacaacaa atccaataag
    21601 aggaattaac cagtctttgc cggattccat ccctaaaaat ggaggaaaca taagatttcc
    21661 tgcaccaaag aacatagaaa ataaagcaaa accaactata aaaatatctc tcatctgctt
    21721 actcacacta aattaccccc tttgaaaata ttttgaatat taagataatc ttactttatt
    21781 ttcagaaaaa tgtcaatctg gtaaaaattc acacattgtt aacgttttcc caatttattt
    21841 tatgaatatt tttttcattt tatgataatt cccatcaatt tcgttaaatc aattgcttgt
    21901 gacacatcaa aaattgctcc tctaatatca tctataccaa tctcaattcc ctcaatatta
    21961 ttagtagtaa aatctatgcc agaaagttta gttccattaa agtttgcttt ttttaaattt
    22021 gtatactcaa atactagatt gtcacctttt acttcttgaa atacagaatt ttcaaaattt
    22081 gaatctaaga tagaaactat cttaaattta gagaatgaaa agttagaata cttacctaaa
    22141 acatccttga acaaaacgtt tttaagtata caatcatcaa atctaactcc tatcaattta
    22201 ctatttttaa attcaactct gtatatactt cctccatcaa aaaatgtatt tgataaattg
    22261 cagttttcaa ataccacatc aagtaaatca atctttttta aattacaatt ttcaaaagac
    22321 acatttctaa atatacaaga ttcaaagcta actcttacag aatctaaatc acttataact
    22381 tcattttcta taattttatt aaatattttt tcatcattaa atatatcttc aagtatatct
    22441 tcaagatttt caataatttc taattctcct gtaaatttag gtttttgcac tttaataatt
    22501 ttagtcattt tcccctccac tataaattat attatttttg atattatttt ttttaatata
    22561 ttaacttaat atacatattt gatatattaa aaagttttta cgaaatatcc atgtattcag
    22621 tacttttata attatatcac aaactcattt ataataaact tccattaata gtataaaaca
    22681 agttagaata attgacatta tattcataca tattcaatta ttggaaaaag taattttttt
    22741 caataaataa ccttaatttt ttataaaatc gacaaaaaaa cgaataattt tattatattt
    22801 attgtaaata atacaatatt acgatataat acaacagaaa aacaaataga aaatgttcat
    22861 ataatattag taatacggtc taatagtttc tacaaactca ccttaaatgg gttttctatg
    22921 aatagaatgt caactctgaa tatatgttct attctatcta tatgaatata tatttttttg
    22981 tttatatctt aaagtttttt ggaggtaaaa atggtaccaa acactaacaa tgtacaacca
    23041 ggtggaaata attcatcatt aagcttttta gacaaaatgt ttaaatttag cgaacgtggc
    23101 tctagcctta aaacagaggt aataggtgga gttactacat ttttaacaat ggcatacata
    23161 gttttcgtaa atccagcaat attatctgaa gctggaatgg ataaagccgc ccttataaca
    23221 gttaccatac tagctacagc cattggtaca cttatatttg cgattttagg aaatgcacca
    23281 tttgctctag ctcctggtat gggattaaat gcattcttca catactcttt ggttataggt
    23341 gcaggaatcc catggcaaac aggtcttggg gtagtttttc tatctggatg tgtcttcttt
    23401 acactcgcag taacaggtct tcgaaagaca attgcagacg caattcctag agaattggca
    23461 gtagcatctt cagcaggtat aggtcttttc cttgcttttg ttggtttaaa aaatatgggt
    23521 gttataatag ctaatccaga tactatagtt tcacttgcag attttacacc aacagtttta
    23581 atagctcttt ttgctcttat cttaatggca atactagaat ataaaaaagt taaaggtgga
    23641 atattgataa gtatagtagt tgcaacaata atatctgtta tatttggatt tgtggagttg
    23701 ccaacagcaa taatctcgac acctcctagt atagcaccag ttgcttttaa attagatatt
    23761 gtaggtgcat tgaaattctc attaattgga cctatattct ctttcatgtt tatagacatg
    23821 tttgattcat tagcatttct tattacttgt tgtaaacaaa tgggtcttga agatgagaat
    23881 ggtgaaataa aagatttagg aagaatgtta tatgcagatg tttcttctac tttaataggc
    23941 tcattcttag gaactagtac tgttacaaca tttggagaat ctgcttctgg tattgcagca
    24001 ggtgcaagaa caggacttgc ttcaatagta acagcagcat tattcttagc tacacttata
    24061 tttacaccat tacttggtat agttcctact tacgctgcag ctcctgcact tgtaatggtt
    24121 ggtgtattca tgtttgaaag cataaaacag attgattttg ctgatagcaa aatagctgta
    24181 cctgcttttg ttacagtttt attgatgcct ttaacttata gtataagtat tggtttatgc
    24241 tttggattta tttcatatat aataatgcat gtagtagcta aagaaactga taaaatcagt
    24301 attacacttt ggattatagg tttacttgca gttgtaaact tagttctaag ttaatatttt
    24361 taaatagttc taggtcaata ttttaaatta tatagaataa aatcttattt attttaaatt
    24421 tataaatagc aaaatcactt tatatgtaaa ttgattttgc tattaacttt gtatagaaaa
    24481 tttattatca taatatatag atataaaaat atatagaaaa ggagtggtgt ttatgtcaca
    24541 attacttata aaaaatgcat atctaattac tatgaatgca gatagagagg tatatgaaaa
    24601 tggaagcata cttattgaaa ataatattat aaaagaggtt ggtaagtttg atattaatat
    24661 tgtagataaa gatgcagaga tatatgatgc taaaggaaaa atactaatgc cagggctagt
    24721 caatactcat gttcacttat ctcaacaatt aggacgtggt cttgcagatg atgttgtact
    24781 tttaacttgg cttagagaaa gaatttggcc atacgaaagt agcttcaatt atgaagattc
    24841 cttgatttca tctactgcat gttgtgttga attgataaaa tctggtgtca ctacattttt
    24901 agaatctggt ggtcaatatg tagatgctat ggttgaagct gttgataaaa ctggacttag
    24961 agcctgttta gctaaatcag ttatggatac aggagatggt cttcctgagg catggcaaaa
    25021 aactactgat gaggaaatca acactcaatt agacttattc cataagttta ataatacatc
    25081 taatgagaga attaaaatat ggtttgcatt aagaactatt tttaatacaa ctgaagaatt
    25141 acttgttaga actaaagaac tagctgataa atacaataca ggtatacata tgcatattgc
    25201 tgaaatagct gatgaaattt catttgtaaa gcaaaacaat ggagttggaa cagttgaata
    25261 ccttgataaa ctaggtgtat taggaccaaa tcttttagct gctcatacag tttggcttac
    25321 tcataaggaa attgatttat ttagattaca tgatgtaaaa gtttctcatg acccaggttc
    25381 agctatgaaa gtggttctag ggtttgcatc aattcctgaa atgttagaaa aaggaatacc
    25441 tgtttcaatt ggtactgatg gagctccttc aaataataga atggacctta tgagggacat
    25501 gtatcttaca tcactaatac ataaaggaag aactttaaac ccaactgtcg taccagctga
    25561 agaagtctta gaaatggcta ctataaatgg agcaaaatgt gctttactag aaaaagaaat
    25621 tggtagtctt gaagtaggaa aaaaagctga tatgattatt ctaaatccag atacaattca
    25681 ttgtttacca atgcataatc caattggaaa tatagtttat tctatgacta gtgaaaatgt
    25741 agactctact atttgtgatg gtaaatggtt gatgaaggaa agaaaagtat tagttgtaga
    25801 tgaatctgaa ttattaaata aagttaaaaa acaagcttct aaaataaaag ataaagcaga
    25861 agttaaaatt ccatctaaat ttaaaattat aaaataacat aaatttcaat tgttttgtaa
    25921 atatgaatat ataaatatat ttatatacat catatataca aaacaattgt ttttttattt
    25981 tatattcatt agcattgctc ataaaataca ccataattcc agaaaaaata accaatcagt
    26041 taggattaca tcatctaagc aatatataaa cgtcttagtt tataagtttt attctactct
    26101 tatctaaaac catctttaaa gagttttcaa ctgtttcaat tacatcttta taactcaagt
    26161 acacatttgc gtagatacaa tcttcatata aattatattc agttactcta caatacagca
    26221 gttttcctcc atctaataaa ttgctcaaaa tatagttttc ttttcttggg acatagccta
    26281 tcacatatcc agtttcacca actattttaa tagctttttc atcatataga ttatctttct
    26341 ctctagttaa atagtatatc ttacttttct ccaattcttt ttcaagatat tctctatttc
    26401 taaaccttga accagcaaca gctattgaag tcaaatagat atccttacca tgttcatcta
    26461 cttttatttt ttcaatattt acaaattctt tttttaaatt attactttca tataatactc
    26521 ttcttaattc atccttcaat ataacatttt tttctttttc atacgcttct ttaacaattt
    26581 ttaattcttc aagagatagt ttctctctgt atctttttaa gatatttatg gattcttttc
    26641 ttacttcatt tatatttcca aatattcctt ttaaagatat attctttcct tcaggatata
    26701 gtgatttact tcctttaagc acaataaaaa ataacatatc atcataatat tcttgagtca
    26761 atttatcttt ttctatatct ttcatttttc caattaaatc atctatttta aacgtctctt
    26821 caaaaaaatt taataatttt aatctagaac ttgtcgttcc ctttttagat atatgccaat
    26881 atacctcaaa atctctaata tctctattta gatatggcaa caagtcatca aaagataagt
    26941 ttacatcata aatttctgac atttttataa tatcttctgt ttttccacta gcatctctta
    27001 atgcttcaaa atatatattt ttccattttt cactgagcaa gataccattt atttcttttt
    27061 caaattcaat cttattgcac tctatatttt catcttttaa gacgtttata gctattagga
    27121 aaattgaata taaactttca aagttagtcc cataatttac tacagtaggt aaaaatcgat
    27181 tcactaattc taatttatta cctatatatt taaattctac acttagcaag taattgcata
    27241 taagacgtgc taaattattt atcttttctt tatctaaatc tcgtttttca agatattcat
    27301 tcaaatctac aattgaaata atatagttca tcaataatcg ttcgtacttt gtatccttat
    27361 aaccatcttc aattagatag gaatttattt tagaatctaa attttccata ttaacaatag
    27421 caaatacttt tattgaacct gtagcctttt tagataaatt aaataaatat gtattgtaaa
    27481 attcaagttt tttaatagta ttactcagat aaaatacgta ttctccagat ttagaaaatg
    27541 tatctacaac ttctcttaag ttttctacat ttagatattt ctcacttaaa actaacccta
    27601 gttttacata ctcaactttt ttactcttat atattaattc tttagttaat ttatataacc
    27661 atttctcatc aataatcatt tcttttacca aagtatttat ctttttcata aaaatttcga
    27721 aataacaaat taaagactta gaattactac cctccaataa ataaatttca ttagattcac
    27781 ttttatacat atttaaaatt tcatctacta gattatttgc aagctctact tgttctctta
    27841 acggtatact ttcatatata cataggtaat tcatttcaaa tgattctttg tatccatcat
    27901 aaccattaaa ttcctgcaat cgcttaaaaa cattctccac caaattatcc tcctttacat
    27961 gatgtaattt atattgatta tactacttat ttcatcaagt ttacatttat acgcaaaaaa
    28021 atattactag aaattgaaat tctagtaata tccttattat taattatgta aataccctat
    28081 cttataactg taaataatat ccttattaat tttaattact tttaataaaa atctatccta
    28141 gatttagact tctctatgca tatattatac taatattaga catcataatc atacactttt
    28201 tctttttcat atctcatgtt tacaaacaat gcaagtaaaa ttccaacaaa tgttattgcc
    28261 acattaaaca atacaacata ttttggtcca ttaactcccc ctgattttgt aataatacct
    28321 gctatattta aaataacata gtttgctata ctagatgcaa tcataactat agatgttatt
    28381 tttcctttat tagttggaaa catttcattt gcagttgacg ttgttaactg aagaacacct
    28441 cctgctgctg aataacctat tacaaatccc cctaacatac aaatagttgg agtttgaaca
    28501 aaatatacaa ctaatagcat aagtaaagct attataggat atataactaa tattcttatt
    28561 ggtttaatat attttttaat aagtaaagaa gttattaata ctgcacatat tactcccatt
    28621 gagtaaaagg attgaatttt tgtagggtca gccatcccat acaatttacc caattcctga
    28681 ttacaattta accataatac aaatgtagat gtacatgtaa atccaataca aacaagagct
    28741 atacttgttg gtgtaaattt catcttctct gatttaactg ttttgccttt gttatcaata
    28801 acattattag ctggtggaaa tggtaacaca gctatcaaaa aggcatctac tacaataaga
    28861 atcgctgtta ctataaaaat aactttaaat gatattgaat ttgctgcaac aaatccaatt
    28921 ataaaaggaa gcaaaaattg tgctaaagct attgtaaatt tagtaaacat atttgctatt
    28981 gttcctaaac tagcaaatat ctccatacaa gaaggagtta cacaggtatc taagaatgaa
    29041 tttgctgccc ctccaattat tgcaaataca tatgctatat aaaaatttgg tgaaaataca
    29101 attccaacaa agaaaattgc atgtagaaag tttcctataa gaccacttac ttttcttcca
    29161 tacttatctg aaataggtcc tgcaaatgga taagatataa gtctccctaa tcctagtgca
    29221 gcaataacag ctaaaacaat acttacatcc aatgttccat ctgataatgt tttagccccc
    29281 cacattgatg aaaattctgg tttgtattgt cctaaaattg aaattccaat accaagtaaa
    29341 aaatatgaaa aatacaacgc tatggcagta ggataatatt ttttattgtt cataattttt
    29401 ctcccattct tgttaattta ttaacatttt tgtgtacaat aaactcatcc ccataatgga
    29461 tttaaagtat agtcagttaa aacttcaaat ttaactggac tatgaggcaa aacccactat
    29521 gacaatttgt aatttattat taaaaatatt gaaatacgta tgttttttca ttgtttaaga
    29581 tattactctt atctatttaa agcataattc attaacttct tctacaggca tttctaatcc
    29641 agtatataga ttaaaagctt ctgctccttg gtataataac attcctaatc caccaatagc
    29701 cttacatcca ttagcttcag catcttcaat catttttgtt ttcttaggat tataaacgac
    29761 atctgttact actaaatctt ttcttaaaac actagtatct tttatatttg tttcattgtc
    29821 ataaggcttc ataccaataa gagttgcatt tgtcaatata tcacttgatt gtatctcctc
    29881 ataaagtttg tttgtatctt ctaaatcata tagattaaca acacattctg gtacatcttt
    29941 ttttatattc tcaactgttt gctctgctct tttataaaaa tcatccttag gattaaagat
    30001 agatatttct cttgctccat ctaaagcaca ttgtacttgt atagcagttg ctgcaccacc
    30061 agcacccata attgtaatct ttttaccttt aacttctacc ccattttctt ttaaattacg
    30121 aacatagcct actccatctg ttatatgacc aactaacttt ccattgtcat ttacaattgt
    30181 attacatgct ccaattatac gagctgctgg agaaagttca tccatatatt ctgtaacagc
    30241 agatttacat ggcatagtaa cattggctcc ttttatatta aaagttttta ttgctaaaag
    30301 tgcctctttt accttatcta ctgtgatatc aaaggctaaa tatctataat ctaaatctaa
    30361 tttcttaaaa ctataattat acatcactgg tgatttagag tgaccaaccg gtgtacctat
    30421 taatgcaaat aatcctgttc tacctgaaat ttccataact ataatctcct ctcaatatta
    30481 tcattttctt tgcaaataac ctattcagtt atttacaaag aaaaatttat ttattattta
    30541 tatatttaat gctacttcaa aagcttcttt tgttgcatct aatgccctac gagcttttac
    30601 tgcatcacca acaatataag tttcttttac aacttctttt ataacttcac ttaatgggtc
    30661 gtaattacga gaacccatag caagtactac tgaatcaaaa ccttttaaat catgctctgt
    30721 gccatctgta agtaaatagt cgacaccatc atcataaaat ttagaaactt ttgcaccagt
    30781 aatggtatgt atattataat tttcaaaatc attcataagg aatttacggt gttctgaaat
    30841 tacatctgca ccaacttctt ctctaagctc aataacagta acctcatgtt cttgttctcc
    30901 aaggaaggct gccacttcac atccaaccat tccacctcca acaacaagta cttttttccc
    30961 acaagatttt ttaccatcaa gaaggtctac agcatgaatt aatcctgaat cattgattcc
    31021 tggtatagga agtacaagtg gagttgctcc agtagctata ataactacat caggtgattt
    31081 ctcctttata agttctactg tagcttctgt attagtacat atttttacac catattgatt
    31141 acattttgaa atataacttc taactaagtt agtaatatct cctttccctg gaggatatgc
    31201 agctaaacgc atttgcccac caagaacttc agatttttca actaaagtta cattatgtcc
    31261 tcttttagca catacccatg ctgcaagcat acctccaaca cctccaccaa caacaagaac
    31321 ttctttgcta atttcagctg gcttaagctc tgcttcatgt cctaatatag gatttgcaag
    31381 acaggctata ggtttgcctt ggaacatatt tggtacacat ccttgtaagc atgcaataca
    31441 tggtatcatt tcgtctagtt ttccattttt agctttatta ggcatttctg ggtcagccaa
    31501 gctttgtcta ccgaatgcta ctaaatcaca tcttccttgt ctgaccatta actcagcaaa
    31561 ctgtggctct gtataacgtc caactgttat tactggtata ctaacagctt tttttatttc
    31621 agtaactaat tctgcactga atccagcatg taaagtcgta ggagcccaca tatattcatc
    31681 atgtatatgt atactacgtg aaacatgaag tccatctatt ccacaatctt ctagatatgc
    31741 tgctattact gaactatcgt gtacatcaat tcctcctgga acatcatcag tgctgtttat
    31801 acgacataat attgctagag aatttcctac ttttttacgt atattttcaa tgataagacg
    31861 aggtaatctc attctatttt caaaacatcc accaaactca tctacacgct tatttgttct
    31921 ttgtgatata aaactactaa ccagatatcc atgagcgcag tgaacttcaa cagcatctgc
    31981 accagctttt tgtgcacgta atgcagcatc tccataagat tctataagtt catatatttc
    32041 ttctgttgtt attgctagtg gtgtattacg accatttgat gcaggtattg cagaagcagc
    32101 ttttaatgga tgtcctgcta ctttttcatt tccttcagaa ccagcatgtt gtaattgtat
    32161 agataccttc gaacctgcat catgacaagc atctattaca tttttaaaac tatctattgt
    32221 gctatcatca tataaacaag gcttacgagg acctcctttt gcttttttgt ctacaacact
    32281 agattctata gttattaatc caaaaccacc taaagcacgc tcaagataat aagccttaga
    32341 agtttcactt aaagtaccat ctgtgtttgc aaaattgttt cccataggag gaactacaaa
    32401 acgatttgga actgtcattg aaccaattct tataggtgta aacatagaac taatcttcat
    32461 aaggttttcc ttcctttcaa gttttatatt taaaagtttt atattataat actctgtata
    32521 tttttatatt atataagttt attttggaga tacttcagac catgctttat ccaaaacttt
    32581 tttagttgca ttaaatacag tttcagcagc agtggataac cctttagata ttagagaatc
    32641 agatattact tctgccccta tgactcttgg tgatatattg tgttctttta ttattttcac
    32701 aaattcctct gtgtttccat atccttcacc tggagccaaa cggtcatgta gtgattcatc
    32761 cctaagtttt tcataaggag tttctaaaac atcacacact tgaattgata ctatcttatc
    32821 tgctggaaca ggtgcaaggt cctctgctgt ctgctttgct ctagcccagt gccaagtatc
    32881 taatataagc attgcatttt cacgattaca tcctttcaca acacgccatg cagtagccaa
    32941 atctggtaca ccactatatg gcataaactc aagacctata ataagttcac ctgctctgtc
    33001 acataattct cccaatgcag ttataatttg ttcttctggt atcatctcta ataatccaca
    33061 atttatatgt ttaacattaa ataagtgagc catatgataa acattttgct ctttttctct
    33121 ttgagcttcc gttctatctt cttctcttcc ccattgagtt atatattcta cttctgtaac
    33181 tttcatatca tattcattaa gaattgcaat catttcttca tctgtaacac ctgcattttt
    33241 tgcatcaata taattttcag cacgcaatcc aataccatca aacccagctt cttttgcaat
    33301 acgaactcta tcacggaatg aaacttctgt tcccaatgta taagaactaa ttgtaattgg
    33361 aatattaaga tttttttgat tattcatagc ttaaatttgc cccctttatt ttctttataa
    33421 ttaatagtat ttttgatttt atatttttat ttatcctact agtagtatta ttttacctta
    33481 aaaataaaag tattttttga tttctattta tctagatttt ataaatttat tgtatcacga
    33541 gactttacta ataacaaatt gataatttcc tattaattca tagattttgt ttatagattt
    33601 tatttataag ataattcttg tatttttcta ttaggtcgta taaatatatt tatcttataa
    33661 ttcagacaaa aaacgataaa tttttttaaa agcttttatt cttactctat aatcatatat
    33721 aataaaaatg taaaaatatc ttaaaggtta acttctacaa atatataaat aaaaatacct
    33781 atgaaaggat gaacaaaaat tgaatttata tcacttacgc tattttgtta cattggcaca
    33841 tttagaacac tatacaaaag cggcagaaaa tttatctata acacaaccaa gcttaagtca
    33901 tgctatttct ttactagaaa atgaacttgg ggtggctcta tttgaaaaag aaggtagaaa
    33961 tatagtcctt actaagtatg gaaaaatatt tttaaaagat gtggaaaaat cattagaaat
    34021 tttagattca agtgtaaaat cattaaaaat aactggtact ggtgaaggac aaatagactt
    34081 agcttttctt agaacacttg gtactgattt tatcccagac atagtgcaca aatttttaaa
    34141 atctaatcct gctaaatcaa tagattttaa atttcatact ggtgtaacta ctgacattat
    34201 tcaaggtctt aaagaaagaa aatatgatat tgcattttgt tcgaaacttg aaaaagaaaa
    34261 gggaattgaa tttatacctg ttgccaaaca agatttagta ctaattgtac catatagtca
    34321 tccactagct gcaaaggata ctatagattt aaaagaaacc ataccttatc ctcaaatagt
    34381 atttaatcag agaagcggtc ttagatatat aattgatgat atgtttaaaa aaataaatca
    34441 acagcctaat atagtctatg aagtagagga agaccaagta attgctggat tagttgcaaa
    34501 aaatttcgga attgctgtag tcccaaatat gaatatgctt agctttacaa aagtaaaagt
    34561 aattcagatt attcacccaa gttgggaaag aaacttttac ttagcattta taaaagatag
    34621 atatttgcct cctgcaatta aaaactttaa aaactttgtc attaaaaacg ctcaattata
    34681 atttattaat aaaggggtta tttttaaata tcctctttta ttctttttat aaaataaaaa
    34741 aatctatact tttaaaagta tagattccta actgacagtc ggcatccgag tctcagtaat
    34801 tatcgttata caacagcaac tggattcagt tcctgaataa ctaggttact tacattatat
    34861 cagatttttt aaaatttgtc aattgtatct aacgcatttt ttcaagccat ggtccaacag
    34921 gctctacaat aggaacttct ttaaatcccc aatttcttat atcattcaca ctcgttggag
    34981 tatatatttt gtttctgaca gatttgaata ttttgttttt ttctccatat tgcatacact
    35041 ttggattagc ttctattaac cctcttcttg ctctgctaag aggattacat aaaatatctg
    35101 ctatttctaa accttctcta tagtcagcat cttctttttt ggcaattata aaacccttaa
    35161 ctttatctct taattcttca tctatatcta agtatattgt tccattatta aatacatcaa
    35221 aaaacgcctt ttgtactttt aagtttgaga catcatccct tgactctata actattcgtg
    35281 cagattctac agtttcatta tttacaaatg aataaaaatt ctgaagaaca tgtataaaag
    35341 ccacaacata cggttccttt gaaggtgcat aatatttctt taatctagct ttatctactg
    35401 ttactgatat tatagtacac tctagtctag atagaaataa aggcaactca tcatagaata
    35461 acttaatctg tgaatcatca aacttctcaa atgctcttga ttttcttgat atatctgtca
    35521 aatgtattcc tatgttacta gttccaaaac aatactcttt aaatgcatcc atttctttcc
    35581 tcaaagaaca tacataatcg ccttgactta ctgcatattt atattcaaaa attactcctg
    35641 tcaatgtaaa tgggtcttca tgatttatat cagctcttcc actttcatca ataaacatta
    35701 tatatttttt ctttataatc ttactcaccc tcttaacata tgatgatagc atctatattc
    35761 attttatatg agttttaaaa atattccaag atttttatat aacttaaact taattttata
    35821 ctaaaaaatt gagatgtaaa acaatcaagc ttttattgat tgaatttcac atctcaatta
    35881 taattatttt tcaatatata tttttactat tttgcaagaa tatccattaa tttatccatt
    35941 actatataag atactccgcc tcctatttga taaggagttt caactttttt atttgcaaat
    36001 actctttgtt gctctgatga taatcctgaa ttatccatta aaactattgg tgaatgtaat
    36061 tttacagcta gtggtccagc tgataaagca tctactaaag catctgattt actaactaat
    36121 acagcctgta aatcagtatc tccatagaat ttttctatta ctttggcatt agtatctact
    36181 ctactatctc catatattct atttcctgaa atatcttcag tagttatatc attcattttt
    36241 gctattactg aatcgttaat tgcacttggt ccacctataa agtatgcatt ttctaatttt
    36301 ctttctgtta gccatttata agattcttct gtaattccat ctttattgac taatattata
    36361 ggttgttttt cttccccagc tttagaagct acagataaag catctgcctc cccatttcca
    36421 gaaaccatat atgcagtttt tatttcttct cgatttccaa gttcttcagc tattcttgta
    36481 gcagtttgat atctatcttg acctgctatt ctctttgttt ctgtgttgaa agtagttttt
    36541 atttcttgct ctaatttaga acttattgca ttttctccac ctatcaagat tactgtttta
    36601 ggtgctaata acttcatttc ttcaacagtt tcagttggta aattagctgt attagtaagt
    36661 agtattgttg agtcatagct acttgctaaa ggagttgctg ttataccatc agctattgca
    36721 ttaccattta ctaatattac agtatctgag ctatcagcat tccagtttcc aactgaactt
    36781 atctttttag ctgtatcaaa tctatttgca cctataattg tatcccatgt aggatttata
    36841 gttccatctt cattaaaagt ataatctttc ccatctattt tttgagaacc agttagcatc
    36901 tttccatctt tgtctaaata gtaagactta ccatctattt gttgccatcc tgtctgcatt
    36961 attcctgttt tgtcaaagta atacttatta ccatctattt cttgccatcc tgttactgct
    37021 aaaccatcag atcctagata gtatttcttt ccattctttt cttgccatcc tgtttgcatt
    37081 actccatctg agttaaagta ataagttttt ccgtctatta ctttccatcc agatactctt
    37141 gctccatcag ttcctaaata atattttttg ttattaattg ttttccatcc tgtttgcatt
    37201 actcctgaag catcaaagta atacattttt ccatttactt ttagccaact attcttttgg
    37261 tatgttccat cagattttac ataatacttc ttaccatttt ctgttttcca tcctgtttga
    37321 tttagattta tcttatattt tgccgctatc tttacatagc tgtcattact ataatctata
    37381 attacatctg aacctacagg aacttggtca aataaccatc taacatcttt attgtgcatt
    37441 cttatacatc caccagaaat atgctttcct atagaactct cattattatt tccatgtatt
    37501 ccatatgtat ctccataagt tccttttaat gctaatccca tccatctatc tcctaatgga
    37561 tttcttggac ttcctccagg tatattacct ttataatatg gtctattttt tatcttgtta
    37621 actacttttg ttttccctgt tggtgtttct gacccctttt tacctgttgc aactctaaat
    37681 tcttttacaa gtttattatt tacaaaatat cctagagtat tttttcttga atttactata
    37741 atcacatgtt tactggctgc gcttgattct ggtacgccac atgcaaatac taaaactaaa
    37801 gtcagtgcta gtactaaata cttttttaga ctttttttca ctataacttc cccctctttt
    37861 agaaacatta ctacatgtgt ctaattataa cataaaatta ccaatacctt atatttacaa
    37921 atttgttaca tttatacata taagtatata ttctattctt catacccatt aggattcata
    37981 ctttgccatc tccatgaatc ttcacacatc tcttcaagtt catacttagc tttccatcca
    38041 agctcttttt ctgcctttga agaatctgca taacacatgg ctacatctcc agcccttctt
    38101 cctacaatct tatatggtat ttcttttcca cttgctttag aaaatgcttt tactaaatca
    38161 agaacactat acccctttcc agttcctaaa ttataaacaa caagtcctgg attttcttct
    38221 aatttttgta atgcttttac atgaccagca gctaaatcta atacatgtat atagtctcta
    38281 actccagttc catcatgtgt tggatagtca ttaccataaa cactcaattc cttcaattta
    38341 cctactgcta tttttgttat ataaggcatt agattgctcg gaactccatt tggttcttca
    38401 cctattctac cacttttatg agcaccgact ggattaaagt atcttaaaag agctatatcc
    38461 aatgacttat ctgcttttga tatatctact aacatctgct ctatcataag tttagttctt
    38521 ccatatggat tggttacaga aagtggaaaa tcctctaata taggacaagt atgtgggtct
    38581 ccatatacag tagctgaaga actaaataca aactttttaa caccatattc tctcattaat
    38641 tcaaataaat ttaaggtact tattagatta ttgctgtaat attcaattgg tttttctact
    38701 gattcaccaa ctgcttttaa agctgcaaag tgtataattg attcaatatt attttcttta
    38761 aatacaacat gcatttcatc tttatttctg atatcaatat tataaaattt tactggtttt
    38821 ttagataatt ccttgattct atcaaccact attgagttgc tattacttaa gttatcaact
    38881 ataacaactt cataacctga ttctaaaagt tctattgctg tatggcttcc tatatatcct
    38941 gctcctccag ctactaaaac tgccattgta attacctctt ttctaatatt tatttttcac
    39001 ttactttttt tctcatatag tccattaaat catcttttaa attttctctc tttagagcaa
    39061 agtctattgt tgcctctaaa aaaccaatct tatctcccac atcatatctt ctaccttcaa
    39121 agttataagc ataaatagcc tcttgttttc caagagtttg aagtgcatct gtcagttgta
    39181 tctctccacc tttaccaggt gtctgtttct ctaatatgct aaatattgca ggagttatta
    39241 tatatcttcc aagtatagct atatcagatg gagcttcttc aattgcaggt ttttcaacca
    39301 tatctttaac tttatatact ctatcttcga tatgttttac atccaatata ccatatttat
    39361 tagtatcttc tttagctatc ttttgaacac ctaatacagt tgttttatac tcattataag
    39421 tatctattaa ttgttttaag cacggaacat ctgaatctac tatatcatca cctaataata
    39481 cggcaaaagg ttcatcacct ataaaacttt ttgcacagta aattgcatgt ccaagacctt
    39541 ttggctcttt ttgtcttata taatgaatat ttaccatatt tgatatgtct cttaccattt
    39601 ctaacatctc tgtcttacct ttttgctcta gttctaactc taattcaact gatttatcaa
    39661 aatgatcttc tatagatttt ttatttctac ctgttattat aagaatttct tcaattcccg
    39721 attctatagc ttcttctatt atatactgta aagttggttt atctactata ggaagcattt
    39781 ctttgggctg tgattttgtt gctggtaaaa atctagttcc tagccctgct gctggtatta
    39841 ttgctttttt aactgtcatc tgcatttttt cacccttctt cgtaaatttt ctattgtacc
    39901 aaattaatat accatattta tactttttct tcaaactcta tattatccca atatttaatg
    39961 ctataagata atataaggta gatgaaattt catctacctt tagttttata agttaatatt
    40021 gtattgttta tattttatcc aaaacttata caggtactaa atttcatcta agatgccttt
    40081 tatatcacta tctatatctt catctagata agaatctaaa tcttctaagt caacttctag
    40141 ttcttgatat gtcatatcaa cactgacatc ctcatctata tccatttctg atattaattc
    40201 tcctaaaata ctatttccat cagaatctaa accactatct atatcttcat ctatatagtt
    40261 ttcatttaaa atttcatcta aatcaatctc gtaataaact tcattatttt tttcatcccc
    40321 tgagtccaat cctaagaact catagttaaa agtccaaaca ttgtatttac ttgacatact
    40381 ttattcctcc tgtgaaaaac atattttcat ctagtttatt ggttccataa tcaacagagt
    40441 tatatatttt ttcaattatg tcttttcttc tttcttttgt actattattt aatgtcaatt
    40501 gtttaaatac atatgtattt gttattctct cgaataatat ttcttttata ctatcatcat
    40561 caatatttct atagtttttc cacaataact caaataactt aaacatttcc ctactagttt
    40621 catctacata ataaggatac atattttcta ctaaatggtt taatcttgat atggcttgtt
    40681 ttaaaaatac atcaagactt gcactttcac tttcttttaa cattctataa ttgtatttct
    40741 tcttatcttc tcctgaaatt acaaagatga tattgtctaa acttttttca acttcattta
    40801 aataactgct tatattatat gataaatcag acaatagatt tttaatctgc ttaaacactt
    40861 gtacatcaag tttagtatta tacttttcaa acaaatctat ttcttgattt tctaatattc
    40921 ttggcatata tgctgacaat aaatctaaat tgtttctttg ttcttgtatt tgcttataaa
    40981 gtgaatttat aacttctatt cttatttcat catttaactc tttttctaaa atcttatcaa
    41041 attcagattt catatagtaa atatttccaa agaaattaaa tattatcata tcattcatag
    41101 ctttagacca attcttatat atcacttcaa tagaattttc tttaagtaga ggttgctttg
    41161 catatataaa tacatcttgc ataagttttt gaaccatact tttacttaag tttaaaagta
    41221 ctttttgatt attaaatttt atttccgttt ctacaaaatt agaattttcg ttttcaagtt
    41281 ctttattaat tacaatgtct tttatatcac tattttttat agatatgatt tctttttgaa
    41341 aagactttag aatagtcaag ctatcgaaat cttcttgaat aaaaaatgga gcatgtttta
    41401 atgtatatcc cactatttca ttttctatat cttttaggtc atctatttgc ataatttctc
    41461 tatttttatc atttatatgt aggttaaata catttttatt atcatataat attatatctt
    41521 ctcctaaatt taacttagaa caattatctt tcgctgactt tacaatagtc ttcttagatt
    41581 tcttatttat aaaaattaat tggtcttgat attttactaa aagcatgttt gtgtttttat
    41641 aatcaaatcc atctatattt cctgatatct tgcagaatac tatttcacaa tctttaggaa
    41701 gatttcctat tttttggtta tccttaactc tctcatttaa atcagatggg actacactat
    41761 ctatattgtt attaaatata gatacagacc ttactataat cccctctctt tccatatgaa
    41821 agtatccctt caatgacact cttttatctt ctaaaatgta tctttctata tcatcaaaat
    41881 ttatttcaaa tctatttttc ccactgataa atataaactt ctcattatct ttattaattc
    41941 cacccatata aaacttattg tcatctaaac ttaatatagt catattatcc tttagataga
    42001 atataaattc tctttgactt ttgcagatta aatcatattc atccaaagtt attttcatag
    42061 tcaaatttgc tgtaacattt ttacttgaat tttcactttt tatgtaaaaa ggcaagttat
    42121 ttccatagat aattatttga gaatcttcta aaactgcctc taatttttct ttattgtctg
    42181 aaaaactata tatatatttt acacctgtat ccttattaac ttcatctgat ttgctgatta
    42241 ttatattccc tagatttgtt atatgaagct ttttatattc ttttgagtat ctacttatgc
    42301 cactaagctc aaacccatct gaaagctcat atatgatttt ttctcctaat ttcaacatac
    42361 cttcaccacc taaacagaat tataagtatt ttataaaggt gaacaaaatg tctcacaata
    42421 aataatattt tttttaatac tttttattct gagacatagt ttctcctttt ctataatgct
    42481 ctaagcacct tcaactattt cttcataaag tttatctaaa tgtttaacat attcacgata
    42541 tccagatttg ttctttaact cacttcttaa atcttcatat ttttgtttaa gttcttcagc
    42601 actcaaagaa ggagctgatt cttttaattc ttctaactta taatcatagt acttatcata
    42661 catagctata tatgtatcaa tagatttctt agctagttca ttacattttt cttgtgcttc
    42721 tccatattga gaataatcac ctatttttat tttatagtat ccattttctt gaattattgt
    42781 tgaagaaata cctttagcct catattcttt tgctgtttct tttgctgttt tttcaacttt
    42841 aagtgaacct gcataaacag tgtaatatac acctttacca tctttatatg cttccatttc
    42901 ttttgctttc ttttcagctt gtgctttttc ttgagcctct ttttctgctt ttgccttttc
    42961 ttctgcttct tttttctctt tttcagcttg tgcttttttc tcttcttcag ttaatttatt
    43021 gttagcttgt tgttgagttg atgactttgg aatattctct ttatcatttt tcttattgtt
    43081 gcctactgtt ataaaatatc ctacaccaac aataaccact ataactactg ctataatagt
    43141 ttcttttaat ctactcttct tagaaacaac ctcttcatca tctaaagaat cttctttatc
    43201 tgatacataa tttttcattt ctttcttgtt ttctctatat ttgtccttag aagaattttt
    43261 agatttttta ttactatttt ctttcttttt aataggtatt actactgatt tttcattttc
    43321 taatttttct tcttttattt cttttgcttt tttatcttct aagtttttac tttctttttc
    43381 aagcttcgat tcattatttg aagatacttt ttcatctaag ttattattta ttggtttttc
    43441 tatttttaca ttacgttctt cttctatatg ttgacttggt tcttcttgtt ttatttcttt
    43501 taattcattt tgctctattt cttctgattt tacttgatga ttttcaactg gtttatctaa
    43561 aattatatca ggagaaatat catttaaatt ctcttcttct tgttcaactt cttcattgtc
    43621 ttttttaata aatccaaata atttagcctt ctttttactc tttttatttt ctggttcaat
    43681 tatatcttct ttattgctgt cgtactcttt atctgtagta tctttatctt ctacaacgtc
    43741 acctatatct tgattattac tatctatttc ttctttaacc ccttcttcag catcatcttc
    43801 tattgaaata ctacttctaa agcaaatatc tttatctgca ttttttatca tgtaaatgta
    43861 ttcttcaata tcgatatctt tatttcttct agttcttttt gatgcaattt catgattttc
    43921 taattcacta tagttatctt ttattagatt ctgtgcttta ttccatgtat cttcactaat
    43981 ttctgtttta tttttaatta catagtccac aaattcctta aaattttcag gaccaaattc
    44041 tccaattata gtcagtctca ttgcaccttc tataaggtct ctatttcttc tctttaaaaa
    44101 ttctaataca accgttgcac aagcaaaatc tttaataatt tctttgccaa aaccatatcc
    44161 ttcaacagaa tgaagttctt ctaatccaca taacttctta tattcattgt gtattgtttg
    44221 agatacactt tcattattta agctatttaa cttatctata aacttcgatt ctatatcatt
    44281 tgattttgat tcatgtttta cttttgaatt tttaatttca tttaatagca tgtcattttc
    44341 tgaattatct ttacctaatt gcaaatcctc aatttcagtt gcttttattt ctactttgtc
    44401 ttgttcgtta ttctcttcca cattattagg taccacatct ttattgctag ctaatatttt
    44461 gtttacacag aatataattt ctctttttaa ttctcttttc gcatctgctt gatttttaag
    44521 aaataaatct ccacattctt tcttttctaa acttattttt ctaagagata tattaagaag
    44581 atctttatat aggtttaaaa ccttataatc cttttctaaa cgtcttcttc tctctgatag
    44641 ttccatttta tcataagcta aaaaactatt taaatcattg gcttttagag agtctaatcc
    44701 ctctttcata gccttattta catactttct acattttgct gtagttaatt ctaaatcttt
    44761 ttctaattca tctatttcag gtatgtactt atctactatc catttgccaa taagtggttc
    44821 tgtatttctt gctaatgtct tataaaacaa tatattaaat tttaaaagct ctgcatattt
    44881 tgcttcatta aattctactt tttcaaattt cttttccaaa acaccatcta gcttttcatt
    44941 tattttagac tcttgtttta aaaaacttgc tgtgacattt aaaacagtgt ttcttattat
    45001 attattttca ctcaaaacct tcactcctta aatcaattat tttattgtaa tatttacatt
    45061 gtgcaaagtt gctaatttga ttatgatatc taaataatta tttactaaat ttgctacatc
    45121 ttatatcata tcatattatt tacatcattt tactttttct ttttatatct atcttatatt
    45181 ataccatttt taatatctgt actaacttat attacaatat tcctcaaaat tttaaaagta
    45241 gattagacaa atttacaaat aaaaaaacat cagtttaaac tgatgttttt gactatcgaa
    45301 ataattaagc aagtctataa gcggagttct gtattagata atcatctttc taggcctatt
    45361 gtcaccaata ggctcaagcg acctacctac cggagagtac gagcagcact ctttattcct
    45421 atcttggtct tgctccaggt ggggtttaca tagccaacta gtcgcctagc tgctggtgag
    45481 ctcttacctc gcctttccat ccttaccaca atagtggcgg tttatttctg ttgcactatc
    45541 cttaggatcg ctcccactag gcgttaccta gcaccctgct ctatggagct ccgactttcc
    45601 tcatgtaaga ttacatgcga ttatctggct tacttaatat ttattttact tagttatgtt
    45661 aacacaaatt cttttacatg tcaaagtaat attatactaa aaatttaaat ttattcaaaa
    45721 atagtgtaat atagatatat aaactacatt taactcgagg tgatatattg aaaaaattat
    45781 atagaatagt aattaacatt atactagtat tagtaatact ttacagtgga tttaatatat
    45841 actcaaaact taccaaatac aatcatgata ctaaaatatc ctcagaactt caaaaaaaag
    45901 aatataaaaa agaggattta tcaaatatta acagtgattt taaattttgg ctttctgttg
    45961 agaatacaaa tataaattat ccagttgtac aatctaaaga taattcttac tatcttgaca
    46021 aagattttta taaaaaagat tctatttctg gtacactgtt tatggattat agaaataaat
    46081 ctattgatga caaaaatatc ataatatatg gacataatat gaaaaataaa actatgttca
    46141 acaacctaaa taagtttaaa gatgctgact tctttaaaaa aaataataaa ataaaaataa
    46201 ccttgaatgg aaaagaattt ttatatgatg ttttttctgc ttatattgta gaatctgatt
    46261 atgattatct aaaaacaaat tttaacaatg aatctgatta tcaaaattac ataaatgata
    46321 ttacttctaa atcattgtat aaatctccta ttaaggtaaa tagcaatgat aaaatagtta
    46381 cactttctac atgtacctat gaatttgatg atgccagaat ggtgattcat ggtagattga
    46441 tttaaaactc acagacacag tttaaaacaa taattttaaa ctgtgtcatc ttttatacct
    46501 ataatttgta aattagacca ctaaaagtat ttaatacaaa ataacaaata catcaaacaa
    46561 taaaaaacaa taaaaaaaga ctatgctaaa aacatagtct ttactggagc tggtgatagg
    46621 aatcgaacct acaacctgct gattacaagt cagctgctct accgttgagc cacaccagca
    46681 cacctatttt attgtaaatt agcaaaacta atttttaaaa gttaacactc taaaaactac
    46741 acatatatct taatgaatga a
//
LOCUS       DAEQCW010000017        46427 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.017, whole genome shotgun sequence.
ACCESSION   DAEQCW010000017 DAEQCW010000000
VERSION     DAEQCW010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 46427)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46427)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46427
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.017"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            146..775
                     /locus_tag="KRO40_001022"
     CDS             146..775
                     /locus_tag="KRO40_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2091851.1"
                     /translation="MDKNYTMPIYQKIALDIANKIYTGEIQEDSVLFGRSVLAGKYNV
                     SPETIRRAVKILEDIGVVKSIKGKGVIVLSPDKASSFIKKYRDITNISSYKSTLYNLI
                     DTKSNLENEILDTINKILDYSNRLEIINPLVPVQFTINSNCKYIGQTAAQTKFWQNTG
                     ATIVAIKRGEELIISPGPYIEFLEGDILLVVGDQHIYNSIPMFLYENEK"
     gene            complement(889..2403)
                     /gene="glpK"
                     /locus_tag="KRO40_001023"
     CDS             complement(889..2403)
                     /gene="glpK"
                     /locus_tag="KRO40_001023"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBH2091852.1"
                     /translation="MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGW
                     VEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGITNQRETTVVWSRYTGKPIYNAIV
                     WQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
                     LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELDIPISMLPLVK
                     PSSYVYGHTDERMLSGAKIPIAGCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTG
                     SNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDELKIIESAKDSEMYAN
                     RVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVL
                     EAMQNDSKLKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLS
                     VGFYIGRNEITSKWSVEKEFNPNMSEEKRCKLYKGWKKAVSRALSWEKEDELDI"
     gene            2647..3189
                     /locus_tag="KRO40_001024"
     CDS             2647..3189
                     /locus_tag="KRO40_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091853.1"
                     /translation="MPKILENVKEDILKVSRDMILEEDYSNISIRKIAQRCGISAGTV
                     YNYFNSKQEIIEYITKSEWDLLIRRIEYSNKNTEDYIKKLNIIFTEIRNFINKVHNIQ
                     YNDFLNTFETERFFEMKKHKDDFHEQLSNKVYEALEKESFFNNDKLVCNIIIKMFFSY
                     STYLHIEFEDLKPYIEKLIH"
     gene            3203..5695
                     /locus_tag="KRO40_001025"
     CDS             3203..5695
                     /locus_tag="KRO40_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896283.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2091854.1"
                     /translation="MNHNTSIKNKDSNPKIFLVLTLYLLGIFMGAIDTGIVSPARTII
                     QNSLGVNEKTGIWMITIYTLTYASVIPISGKLADKIGRKYVYLVSIFLFGSGSLICGL
                     SSLFSNFYILLIGRVIQAIGGGGIMPIATAEFGTTFPENKRGMALGLVGATYGIANIL
                     GSSIGSTILSIFGTQNWKWLFFVNLPICLIILIGGVFCIKNNKSESKEKIDKLGTLML
                     ICIIVSLLYGLMNIDFFNFKNSIQDISVYPYLLTFIVLIPIFIFIENRAKDPILSFEY
                     FLNPRILIVLILSLIVGIGMMGMVFVPQYAENALKINAGSGGYFVAILGLFAGIAAPL
                     SGRLIDKFGAKKILLLGFSVSMIGSLYLVLIALKTNTVFSVCVSLIFMGLGMGFTMGT
                     PLNYMMLSNTRLEESNSALATLSLIRSIGTSISPAIMIGFIAHAGLSVQDNIMDLVGK
                     PSTPKIVQLEELENMIDDLKSDPEMAKNLKNVSIPNMNDTSNINMDMTGGKLPKSLLN
                     KVQSADTTNITNITKEISTTMFDEKVPSIITKIQKNVQKGIDGTQSGINGIEDGENKL
                     NSGIKGVQTGIDNMVKARAGINQGIDGVKKGIAGVDKGIKGMEQGLEKQDEAIKELTT
                     AYNKIPTTEKTPTDNENNSNEQNQSNTSNSESDDTKNDSTENKNNNSSENKPNVNEQK
                     ESLNAQIQQLKKTRDDLNTKLQKNKTQKNELSKKLRSMESQKKELQSKLNNSISQKKD
                     MEKSLDTMQQQKKSLQAVLAKTQEVKTEIPKAFDKSKLDYINSIENNRTKIENTLQST
                     LNSGFKQMYITVFCVNLLAFIILLFYKENKTR"
     gene            6116..6514
                     /locus_tag="KRO40_001026"
     CDS             6116..6514
                     /locus_tag="KRO40_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2091855.1"
                     /translation="MDTLGKRIAYLRNSKKLTQRKLMDILKFENLGKYETGDRKPNCD
                     ILMSIADYFNVTTDWLLYGKEKVNVNSSVKEDKEDYLHVTNDEMTILNLYRQLNERDK
                     IKIEGILELKISEYKDLKKHSSNNNEDKMV"
     gene            complement(6731..6940)
                     /locus_tag="KRO40_001027"
     CDS             complement(6731..6940)
                     /locus_tag="KRO40_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091856.1"
                     /translation="MCKLDSDGVIECCRAIDDFITALSNIKSLNMERLNTLTKYSSTC
                     SILLKEGNYEGCTIVYRKMLEELKT"
     gene            complement(6972..7181)
                     /locus_tag="KRO40_001028"
     CDS             complement(6972..7181)
                     /locus_tag="KRO40_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091857.1"
                     /translation="MDARKKWIPFLGVQVKQRLIELNMTQRELAKKIGVNENYLSAIL
                     NGRRTGKKYKSSIYQLLNIEYSEDD"
     gene            7480..7899
                     /locus_tag="KRO40_001029"
     CDS             7480..7899
                     /locus_tag="KRO40_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091858.1"
                     /translation="MDTLGERIVYLRKAKNLKQYELEEMLGCDNLSKFERNIRKPNYE
                     ILKSIAEIFNVSVDWLLNGDNLSHKSDLICDSSSNYPLNSINSNEIKLLNNFRKLNDY
                     DKAKIEGMIELKLHEYEKEKDLGKIEYNKNKDEKIDK"
     gene            8127..8582
                     /locus_tag="KRO40_001030"
     CDS             8127..8582
                     /locus_tag="KRO40_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091859.1"
                     /translation="MGLRDKFAQSFARSKTMSGPEKKANEIMGKLLLKKAILPIVLMF
                     VIIIAGAMLKINSWVTLGINLVIAVGAFFYIRNSSKKYQNFKPYVGNLISLEKKGKKE
                     YVAIIKQGKLPVKLQIAYGGEDLEHVKKNQMVQISYNPDAKIAILVNRQ"
     gene            complement(8803..9063)
                     /locus_tag="KRO40_001031"
     CDS             complement(8803..9063)
                     /locus_tag="KRO40_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091860.1"
                     /translation="MDKLITELSSLGAIGILCALLFKNTMQEKKEDRDMYKKTVENFI
                     ELSTQQQEINKNILVQMGIMKTDVEEIKEDVTGIKGMLQNGV"
     gene            complement(9326..9679)
                     /locus_tag="KRO40_001032"
     CDS             complement(9326..9679)
                     /locus_tag="KRO40_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091861.1"
                     /translation="MFKFDKNKIEQIKQGRKVEMQYKDISDISIGQVKQDDDITNNFI
                     ANAEIYEMLLNQSSVNEASNISSFSVRKSGGESGMVEVYVALILRGKKTIEEVPAVIR
                     EQVRIRCKELEIPVE"
     gene            complement(9696..15017)
                     /locus_tag="KRO40_001033"
     CDS             complement(9696..15017)
                     /locus_tag="KRO40_001033"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012632.1,HMM:NF024930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091862.1"
                     /translation="MKRTKLLQRGNFFGDKNMVVDEFDEGYDNYDFINFFTGCCNYTF
                     GLKNNNILYGCGDNSNFQLGLGEDNTTRKLFTKIPNISTNIKKVACGESHAVILTSDG
                     ELLVAGINTDGQMGLGLEKVGKTVSTFEKVPEIKGVKDIACGLQSTYLLYNDGTLYVA
                     GNNLYGQLGLGTNGASANVNTFTKVDVDNVKAVFSYNKSAFIIKNDNKCYSTGFNNQG
                     QLGLGDKNNRDLFSLVSINDVKTIACGSEHTVLMTYNNDIYGCGKEKCFGNALQSSLF
                     TKIEEVNIKTIACGHGNTMLIDNKGTLKVAGNNDIYQLGIANYSENIDNSFIDLKNIV
                     AKNIFIGLSHSILIDSNNDSYCTGDNTYGQLGSFFDDMHIVEFKKMDSEKYSYSNYIN
                     LIKSEDKLTLLKEEMEIKDIELPLDIHSVRDVVFSPYCTLVILGNGDVYGLGNNRYKG
                     MGSDLPSQLNELTKLSISNVKSIVASKNISGGIFYIKNDDTCYYSGPNSNSIAGVLPS
                     NSDIFKKISIDNVKKVVINTDLSNWFSLIVTNNKQIYTSGKSSSYVNGLSNKSASQYT
                     EIGVSNVTDAYSSYNATFIVADEKKVYATGINTNYLLGVNPNDGVNINLTLINNWFYV
                     NPSGASYSTNSCTNDITKINNIIIYEYMAILCTNYGSFLTGYHGTLWTKPSDSTYRVQ
                     QQGITHAGYISNYIYNYYPTRCTQSSYSTNFAYLYYGESTSNLKNVNPDNLLISGGSS
                     YIHQYGRNYLNNQSSNNIAASNINSGPITSDKAIFLYKALLYLSSNTLYGFGNISESA
                     KELDVSDTQDGYNATNYKKVMKNIKNIFIPPYDLSRDKTRFAILTDKSLFICGYNSKG
                     THGISVNSSLNLNNKINYNKKNSSSEISSNIQEIYSHSKSTYLLTNNNMLYSVGLNDV
                     GQLGVGDEINRKVFTKINIDNIKSINVNRFTDNSKHVFAIKNDNTCYAVGLNNSGQLG
                     IGDNVNRNVFTKINVENVKYVAVYGNTSLLLTNDGLLYGAGNNGKGQLGLGDTTSRNI
                     FTRIPINGVRDVYICNDVSIIVKNDNTCYVCGFVNGYFGFTEGSISTFTKINIENVKS
                     VVTAGSEATFFITNDNVIYTTGKKERVFFSTETNDIKGIRVINNIINAKKIVVNGYTS
                     AILTNDNKLFVGGLSGYGSIANNNNTNSVEDVKDVFVTANNTLYIDNNNNLISSGRDT
                     YGISDESYRDMSVPYYKVSIKKDVDTVFSSYNTIFIKDIYGKFYSSTGDNRYNHLGIH
                     HRYDNDKNEALEGSLHSYFKTDNTSDKIVFNKKNEKLVMFNDKYIKTNNKYINYKNIF
                     KDNFKYTSIILPFEVSDIDISKTHSLAVAKDGKLYGIGSNSYKEINQTLEDIELLTLT
                     EVNISDVKKVACGDNYSYIIKTDNTLWSYGKNTEYQLGVGHNNDVRELQKVTGLPSVK
                     DISIYNSMTLVLTNEGELYAQGYNTNGLFGLGESEKDKIIRTFTKVLTNVKEIKSHND
                     DHILVIKNDNSLWITGKNKSMYKISISITDLYEFTKIPIPEHLNDILDIELSDDTIYM
                     ITKVDTSKASIEIVEKSISQVRVVVQDPNNVIEKLEMFINDELISTKTNLEINSIIFE
                     IPQNKIVLGENKILIKASSPTGDLYSSMFIFKSETGLKVKKDSILMINNKVYSIINIT
                     ENNTDLIVTLNEGLKDDMMENNPIYQLINKTKVQVKINKSDLFKDMKLVEIKKSDSSY
                     QEIYELEEANIKSAQPKIIVEKGDKWTAIKRPSMIFRYDAESNEPQA"
     gene            complement(15034..16017)
                     /locus_tag="KRO40_001034"
     CDS             complement(15034..16017)
                     /locus_tag="KRO40_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBH2091863.1"
                     /translation="MEEKFYIILTKIGREKIANATALGELVGLTKFQVGDSNGEYYEP
                     TEEQTALKNVVWEGNINSLRIDEKNPNWIVIETILPGTVGGFMIREAAVLDNENNIIA
                     IGKYPETYKPRAEDGSIKDLVVKMILQLSNTSNVTLEVDPTLVFVTQKDIQDLDDKFD
                     KNIKEIKVKIGEELLSTEAKNLSGAINEVVEKIKNISIDDVIGGQIQTELSVLKNSYN
                     KLSEKVLDILIYLELESEIDVDEAGYWYDTLTNAKNIIAIEGLKLDLNRKCITGELGS
                     VTFKNVVLPFNANRVRYIHEMDNNFVETKSNRAYSIGQTDITLNKYSYEIR"
     gene            complement(16018..16716)
                     /locus_tag="KRO40_001035"
     CDS             complement(16018..16716)
                     /locus_tag="KRO40_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2313 domain-containing protein"
                     /protein_id="HBH2091864.1"
                     /translation="MKLIDKLPSFDRNYIVEEIQGAYDTELNILKEDIDDTFNQLFVD
                     TATWGLDMWEDILCIEKKELDFDTRRSNIKAKMRSRGTSTIEVIKSICEAYTKSETDI
                     KVYSDEFTFVLSFIANNCDYKTLLDCSDMIERVKPAHLLHYLEPIILDKSMVYCGGGM
                     VCSEEVKVHPYFEPIIKCSAVVNCGAGMISREEIKVYPLSIKCIENNCKINIAIANDT
                     GVENVVVYPKSEVV"
     gene            complement(16713..17765)
                     /locus_tag="KRO40_001036"
     CDS             complement(16713..17765)
                     /locus_tag="KRO40_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBH2091865.1"
                     /translation="MYSDQTYEVIKNRTLENINLDIYKGEGSFLNNMVSGNNLELSKI
                     YLELSKMHKMAFIQDTYNQFLDKRVNEFGVYRKLGTESNGEVEFIGEKGTVINNGTII
                     SYRDLLFVVIKDVTIGSEEGDNSPVQALEVGKKYNLPTNCEFKLVDNISGVTKITNTR
                     SFEGGTDIETDEELKERFYKIQRNQATSGNKAHYEEWALEVDGVYNVKVYPRWDGPGT
                     VKVLIFGKNNQAVDTETIERCQQHIDEEKPIGPTITVVTPLPIEISISAVMKLEDGYT
                     LDNVKESFLESINTYFRDIRGEIIYTKVMGILINTTGVHDLSNLLINGSTDNITINED
                     KIPSVTTVNFSEVENQ"
     gene            complement(17758..18186)
                     /locus_tag="KRO40_001037"
     CDS             complement(17758..18186)
                     /locus_tag="KRO40_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBH2091866.1"
                     /translation="MSTIFPFIGVPEDYILPKTEELPIFREVAWDFEKDEPILEKGDF
                     KIIEKKEALKVWIYKCIKTNRYEHEIYSLEYGTELSELIGQKYTKGLTESEASRFIKE
                     ALLINPYILEVNVKSANFNRDILSANVKVSTIYGEVEINV"
     gene            complement(18186..18512)
                     /locus_tag="KRO40_001038"
     CDS             complement(18186..18512)
                     /locus_tag="KRO40_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 family protein"
                     /protein_id="HBH2091867.1"
                     /translation="MANPINEFIGIIREEGKYHNQPSFFIGKIKSKLPDLKIETNNII
                     LEKEDILIDSWMIDRQLETFDTETNQEHQHEVKNPFIDNFESGDMVIMFRIGEKFAVV
                     SKLVSL"
     gene            complement(18528..20057)
                     /locus_tag="KRO40_001039"
     CDS             complement(18528..20057)
                     /locus_tag="KRO40_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH2091868.1"
                     /translation="MIINRSKDSSSNEISFVSKDMGFLLTQSEVSYNFKDKLVEDIAK
                     QVFAENRLSVGIIAKTNVKYTKMFIGVNGYDTIMSAYTEASKKTKKKYMIEANLDKFN
                     VIEKGTVTLSVMFEEGFNIINTTFSESMENVKNKVIVVDQYGSKISEKIDNEIFKEVN
                     VIMQKVIQQQENQDVDIDSEFNGIEKSCSLKGYGDVSCITGRGVKVKDSYTKLVGLFY
                     IDTDKHTWQNGEYQIELELNFQNLMDEKSAGQDEPKEESNLGGEDYAGGKEFTAEFTA
                     YCPRKEEGGDTDCRKKKLDPSKKTCAAPMVGKYEQTYYTKEFLNKHPLLNYGDEIQVI
                     TGVSGRDGVYKVNDVGPAITIEKNGTYHIDILFGNVEEASKFGRRKGKIIIGGYSGNV
                     SDKAKIVISEAKKHLGKPYKWGGNGPSSFDCSGLMVYCFKKVNVSLPRTSNQQSKKGK
                     KVEQKNLQAGDLVFFHNPVSHVGLYIGNGEFLHAPQKGDVVKISKLSSRRDFNTARRV
                     L"
     gene            complement(20339..20761)
                     /locus_tag="KRO40_001040"
     CDS             complement(20339..20761)
                     /locus_tag="KRO40_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091869.1"
                     /translation="MEMWLRQAEDRFRFPVFPSSFSINGKAAVNSSSILKIGEIATFG
                     GVALKSISISSFFPNKDYTFCDYTGFPSPYDCVNKIEKWMKEGFILRFTITETNINME
                     VIIEGFSYEERDGTRDVYFTLDLKEYKRIKIPKVTPKQ"
     gene            complement(20761..23214)
                     /locus_tag="KRO40_001041"
     CDS             complement(20761..23214)
                     /locus_tag="KRO40_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091870.1"
                     /translation="MGNVREEGINMYLTDNYTPKMNQIISVTDNFRRATVAVSLSTNV
                     MASSIKNSIGSASNRVNSLNSSLRKVQTTASSVSSTMTKLSSSINAVSGVIGSLNGSI
                     MRLAITIAMIIDYFNKLIQKKNEFNSNIMIILIFKAKSDEVEKTKNKLLGNLKKIGGK
                     IWNIVIKAKDMTKRVISSILGKLKQVEKRPYQGSINLKDMVSSAMGRILPKLMLFKNT
                     FWSGVIAIKDMASGIISKVFPKLRLFAGKVWSGAIAVKDMASGILGSIKGKISDLTNG
                     ATIGVAVKKGVDLLGQEQNQKVVLESVMKRNTGKVNQIDVDDYYGSLVRMANDTPFDP
                     EDVVAMGTKAKMISNITGGKKEKDITQAMVDVRALNMNTSSEQDVSAAFLSAAKGNME
                     SLNTLVGENYKTFDEALEGISVKQMGLAKEMSNTIPGIISGAQTSINNGLKSIVKPFD
                     DILGQGLKKIKTFIESGLGNLAGLSEKMAGKIGNVMNGKIIIGNKYDQMQSRSVKNGK
                     EFSDSTQYRISNEAEKRKMMVENKQERFENHAATMIGNAPKAIVNAGSTLLQNIDFTA
                     LIDSLLPVVNLVNNLLDSINNKSPIAQGLISIFGTIVTTAFQLIGPVVEAVSPIITRI
                     FTFLGEYAPQINNFIETLGVIWKTVWETLGPLLETGWKIIEPILGAFFNILDKVCKIV
                     KDICKWWQTMINKIKNGSITGTVLNLVEKSKKNYKDNPYAGTKAGDSGKAYSGKKGNN
                     AFGLNYVPYNDYQTRLHEGEMVLTKQEANQYRSRKNGGNINIAKLADTIVIREEADIE
                     KITSKLVASIQLAQLGGVL"
     gene            complement(23214..23381)
                     /locus_tag="KRO40_001042"
     CDS             complement(23214..23381)
                     /locus_tag="KRO40_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091871.1"
                     /translation="MYYYWKKKGIRPSLFYAMDKGELKLIEAFFALEIEEEVEKMKHG
                     YGVCPLTGGGM"
     gene            complement(23408..23854)
                     /locus_tag="KRO40_001043"
     CDS             complement(23408..23854)
                     /locus_tag="KRO40_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBH2091872.1"
                     /translation="MSENGLSKNINIVDLLLNSDTENLERPSTIVELKRLSTIFGQEF
                     KVMCRALTISKDEEIQNTCLKIDENMKTDIDLPEMQMLTIIEGVCDLDGKLLFKNKEL
                     MDKFKAPTPKELARKLLLPGEITNLYRILQDVMGYGKNAVIEEVKN"
     gene            complement(23968..24396)
                     /locus_tag="KRO40_001044"
     CDS             complement(23968..24396)
                     /locus_tag="KRO40_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBH2091873.1"
                     /translation="MANMEARNVMSGTWGELWLDGNKVAEVKKFQAKMEFTKEDIIIA
                     GQMGTDTKYMGYKGKGSITLYHVSSRMHKLIGEKIKRGSEPRFVAISKLNDPDSYGAE
                     RIAVKNIAFDDLTLADWEVGVKGEIEAPFTFTEYDFLDII"
     gene            complement(24410..25474)
                     /locus_tag="KRO40_001045"
     CDS             complement(24410..25474)
                     /locus_tag="KRO40_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath subtilisin-like
                     domain-containing protein"
                     /protein_id="HBH2091874.1"
                     /translation="MAIGLPSINISFKELATTVKERSARGIIAMVLKDAKALGLNEIH
                     EKEDIPVDLSAENKEYINLALMGNVNTPNKLLVYVIEGEADIQTALDFLETKEFNYLC
                     MPKAVEADKTAIKNWIIKLRDIDKVKVKAVLGKVVGNHEGIINFTTEDVLVGEKKYSV
                     DEFTSRVAGLIAGTPLSQSVTYTKLSDVVDIPKMTKVDAESRVNKGELILIKEAGAIR
                     IARGVNSLTELTAEKGEMFQKIKIVDTLDIIHSDIRKVIIDDYIGKVTNSYDNKCLLI
                     VAIKSYLEELEKSALIESDSTVEIDFEAQKSYLKSKGVDLSYMTLQEIKEANTGSKVF
                     LKAKIKVLDAMEDIDLSIEI"
     gene            complement(25479..25922)
                     /locus_tag="KRO40_001046"
     CDS             complement(25479..25922)
                     /locus_tag="KRO40_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091875.1"
                     /translation="MLKYKEILETIIEILKKNFTESIFIDDESVQGSEGSCFFVSILS
                     VICTPVMLNTNNKDIVISIKYLPKPQSKSIRMYEISDELNKLFNRNIKVTDRKLNITK
                     LEQSIKKEESIYVLNFTFTLNYLDSVYEEDVVYENMKEINLNLGE"
     gene            complement(26171..26611)
                     /locus_tag="KRO40_001047"
     CDS             complement(26171..26611)
                     /locus_tag="KRO40_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091876.1"
                     /translation="MENKKDILFKETDKRLHNYKYLDIKIKNINLDIKRCENEYSGCG
                     AMVYTEKTSNTYNISSSVENEVLKREERLRKLKMEKEDIEIEKEKIENALTCLNDIEM
                     EFFNLFYNSKTKNNMTYISMKLHLDRTSCYNLKKKMIFKLSEIL"
     gene            complement(26716..26913)
                     /locus_tag="KRO40_001048"
     CDS             complement(26716..26913)
                     /locus_tag="KRO40_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091877.1"
                     /translation="MFKNNLKYYRKCKGMTQIQLARKAGITNDYISQIERGIKNPGLL
                     MAKKISSILEQNIEEVFFIQL"
     gene            27082..27402
                     /locus_tag="KRO40_001049"
     CDS             27082..27402
                     /locus_tag="KRO40_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH2091878.1"
                     /translation="MFAKRLRELRKEFGLTQRELGEKVGVSQRVLGYYETENRFPDEH
                     ILNKLADVFNVSVDYLLGRTLVKENIDTVAAHRKNPHEELPEEAQEQLNDYIEFLLNK
                     YKKK"
     gene            27484..27990
                     /locus_tag="KRO40_001050"
     CDS             27484..27990
                     /locus_tag="KRO40_001050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091879.1"
                     /translation="MNNLDKLFELASQEEIIIHYTTYIAGDLEGLYINKHGIKIISLL
                     SNLKQNSKKLTSILAEELGHHFTSLGYYVSSYNDYYTKIIIDKCENKALKWACEFLIT
                     EEDIINIINSGITCVYEMADILNVDITFFQKRLEFLSLKKQSLQLGNNKYLILTNLPY
                     FYIFDPIS"
     gene            28691..29446
                     /locus_tag="KRO40_001051"
     CDS             28691..29446
                     /locus_tag="KRO40_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH2091880.1"
                     /translation="MEKKVLATVGEKEITNIDIENALKSLDPYQAMQFKTEEGKKHLL
                     NDLVNQELFFLDAKEEKLDEEEIFKLEMKKIEENVLKQFAINKVLSSVNVTEDEKVKF
                     FEANKSSFSKPESATAKHILVDSDEKAKEILAQIKSEEISFEDAALKHSSCPSKDMGG
                     DLGTFGRGQMVPEFEEAVFSMAKGEVSEPVKTQFGYHIIKLEDLQESTESTFDEVKAE
                     VEKSLLYQKQNEVYGNKINALNAKYGNLVKYND"
     gene            complement(29589..30017)
                     /locus_tag="KRO40_001052"
     CDS             complement(29589..30017)
                     /locus_tag="KRO40_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBH2091881.1"
                     /translation="MNILFFLTPKSEVAYIYEDYTIRQALEKMEYHKYSAIPIISKDG
                     KYVGTITEGDFLWTLKNDLNLDLKGLEDVPVTDINRKMDNSPVSINADIEDLVIKSLN
                     QNFIPVIDDQDTFIGIIKRRDVIGYCYEIIRGYKNLANDN"
     gene            complement(30438..30638)
                     /locus_tag="KRO40_001053"
     CDS             complement(30438..30638)
                     /locus_tag="KRO40_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH2091882.1"
                     /translation="MKTGVVKWFNNEKGFGFISVEGEGDVFVHFSAITGDGYKTLEEG
                     QSVEFEVVDGAKGPQAANVVRL"
     gene            complement(30821..31990)
                     /locus_tag="KRO40_001054"
     CDS             complement(30821..31990)
                     /locus_tag="KRO40_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidase domain-containing protein"
                     /protein_id="HBH2091883.1"
                     /translation="MGGVALKILKNKNKYIKGIMAFVFLSLATTAGVFLINDLSMKNM
                     EEKVMESANVEGDDVKDQYKLLLENLFDYRNKAILEKNENILKGLYETDKKFGLWAYE
                     NEVKKMKYLENWSSKQGVKFKDIKTRVKIKKIKEKEKDLYGIICSVSTEYKYSYENQK
                     DKENAFRIGTYHYLNVKIIDNQYVITKEWYTDPFADSLNLENIKSDDIRNYIGQQDGV
                     ELQLTDEQKKAIDYAHKYCGAAADEEHGMKFNPNYRDYNPEGGDCANFASQIMFESGR
                     FKKNSIWNYSERAGTKAWVNAQAFKNYALYSGRGSLIAKGSYEEVYKEAYNLRPGDFV
                     GYEKKGRITHVSTVTGLDSRGYPLVTCHNTDRMLVPWDLGWSDKSIRFHIIKINY"
     gene            32226..33047
                     /locus_tag="KRO40_001055"
     CDS             32226..33047
                     /locus_tag="KRO40_001055"
                     /EC_number="2.7.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine kinase"
                     /protein_id="HBH2091884.1"
                     /translation="MQKKVAAINDLSGIGKCSLSVAIPILSALKVQCCPFPTAILSSQ
                     TGYPEFTFLDFTDEMVKYSNVWKNLKVNFDSIYSGFLGSKHQIEIVANFINDYPNAFI
                     VVDPVMGDNGVMYPIFTEEMRQEIKELVKHSDLTTPNLTEACFLTGNDYTKSDYNRDE
                     LIYIAKSVSDLGPSKVVITGILEDDNILNLAYNRDNDHVFFTSVKYNNCSYSGTGDIF
                     TSILCGMLVNKHDLGVAVNTATDFIYKTINYTSQFDTDRNDGVMFENFLSDLTNI"
     gene            complement(33123..34511)
                     /locus_tag="KRO40_001056"
     CDS             complement(33123..34511)
                     /locus_tag="KRO40_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase"
                     /protein_id="HBH2091885.1"
                     /translation="MLGGKKSNNKKVEKLRTIFIKYLSLFFIMTISIVLLLMLSFSVL
                     LSSGVILPANYAEKQFNKYKEQIISSEKVTEDIIPSIYEYGVYTLDGNLISGTFNKKE
                     SKEVWNLMRDIEERHAYSESYIKFFKKDEVFIIKYKIVSEYSSPILRAYLPKPETLGM
                     IIFSIIFFIEIVILSKVFGKKFNIEMELLKNTTEKIEQQDLDFVVESSKIYEINNVLF
                     SMDKMKLALKDSLEKQWMLEENRKEQISALAHDIKTPLTIIHGNTDLLIEINENPELL
                     EYMEYISKGVTQIEKYINTLIDISKTENGYILNKEAISMSEFIKDVLVQIEALASTKN
                     LDVEFYKQDNLPKNITIDRELLFRAIMNIISNAIDYSPSQSKLYISVSVHNKYLKFVV
                     TDCGSGFSKADLSKATEQFYTGDLSRNSKSHYGMGLYIVNNIVQKHNGTLCIENSVKT
                     GGAMVTIEIPIV"
     gene            complement(34646..35404)
                     /locus_tag="KRO40_001057"
     CDS             complement(34646..35404)
                     /locus_tag="KRO40_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBH2091886.1"
                     /translation="MRQLIRIFCSDLIKLKRNFIILMHICIALMGMGLFLWYYKVSGA
                     DNILKIVAYLQVIAIAFPLLSSVVCSMFVEQEYYAGNYKHMLTTSNPKYLTLISKYII
                     LVCLGFVATLVSVLGFKFGISKAYFTSSFYMISILILIGCNLFEYILHLFLSLRFGKG
                     TSIGVGIVEMLLSALLLTGLGSGIWQYFPCAWGVRFITIWSSFSSSKTVEYIKVESIK
                     AYQSTGLICGFVTILAFVILCIWFSKWEGKKSEE"
     gene            complement(35406..36122)
                     /locus_tag="KRO40_001058"
     CDS             complement(35406..36122)
                     /locus_tag="KRO40_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBH2091887.1"
                     /translation="MERFIRVEFQKMKGTFGMKLIWIVPVFCILLCGLGGGQNAAFNW
                     WYTTFLPGALTLISSLIVLKDEKSKYRGILPLPIEMKDVWTGKMIYCIICCFIASIIS
                     AIGVVFVGIIYKETISIGQNIIASILIILLFMWQIPLCMFLASKFGMFVTVLTNMFFT
                     IVGVAVFSTTEMWYMFPYSIPSRLMAVVLHILPNGLPVPEGSEFLNNAVILPGVLISI
                     VLFVLFALATRVWFNNREVK"
     gene            complement(36124..36831)
                     /locus_tag="KRO40_001059"
     CDS             complement(36124..36831)
                     /locus_tag="KRO40_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH2091888.1"
                     /translation="MSNYILQVKGVSKKFKEQMAVDNISLAIKSNSIYGLLGPNGAGK
                     STLLKMITGILNPTSGKIMFEGHRWTRKDLSNIGSLIESPAIYENLTARENLKVHTTL
                     LGLPDSRIEEVLETVDLRDTFKKRSGQFSLGMKQRLGIAIALLNHPKLLILDEPTNGL
                     DPIGIEELRELIRSFPKQGITVILSSHILSEVEQVVDEIGIISNGVMGYQGEVSKEQN
                     LEELFMKVVAENRKRGQ"
     gene            complement(36947..37483)
                     /locus_tag="KRO40_001060"
     CDS             complement(36947..37483)
                     /locus_tag="KRO40_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2091889.1"
                     /translation="MNKIAVSFLIIATTLLSTACMDYSISAVELVDSKESAVVKKDED
                     AKEETTSKMINSKKTTKIPIEIISKDEKIVKYLQIDEESSLKDKLRLILDTLSNEYFN
                     GLDMEVEVKEKDNLVKINLIEPDKKSRVSWKDDYLNEQNIIYTINNIIKNVIQEEDNS
                     IWIEEVEIYYNGKLIELR"
     gene            complement(37585..38655)
                     /locus_tag="KRO40_001061"
     CDS             complement(37585..38655)
                     /locus_tag="KRO40_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 family beta strand repeat protein"
                     /protein_id="HBH2091890.1"
                     /translation="MNKKLAIFAAVLLVIGIIGTTWSGILVMPSLINFGLEKEAELNK
                     ENKLYQEKVNIDKLDIAVDNINVMIRKSSNEDVRVTTRGNNEFYKYSVTLQDKTLVVK
                     GERKSENKIKKIRSFDHLLNTSINSMFSRDYREIRIYVPNNVDINASSISSYLFISDD
                     VDSNNITYKTSSGGFSRAITENKVNRLENLNLISNSNLHLSTKSILGVKNVNIESESL
                     DISSENGDVFINNIEEYIPENVNIKEKIGRNSNYESEFYLYSDMPIAKFLDIEVPNSK
                     VRLDIPVNKYKFNCDIKSKEAIEEFNNDEEYDNDSYDYEHNEEHSNKYRNTREIKGLL
                     NKNLSNLEKEYTIKINSNSLEL"
     gene            complement(38648..39706)
                     /locus_tag="KRO40_001062"
     CDS             complement(38648..39706)
                     /locus_tag="KRO40_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HBH2091891.1"
                     /translation="MNLNKTEFLEILKDYLKKDFSESEVNDILRDYEEYFVDGLIEGK
                     SDMEIIASLGSPKSIAKELILQTKEKNIEEEKIINTDVLNDKFSKFKSDMKKGYSILK
                     DEAKEKYSKSKENIDGKIMNTDILNGKFSRFKSNVKKDYSILKDEAKEKYNKSKENIN
                     DKLTPSIEEGVGGLSRQVIKGLLVVLSLFLIVPAFAFVCAIVSATIALVCSLIAFVIL
                     IPFVIKFIAMVPDVMMFCIFATIAFVGLEILAWQILLFAIKLGKQLLNNYIHWIKRKN
                     IYIKANEKMEKRKKATLNDEDLNKDINENSYNNDYYNREEESIKETDEYNDDSINFEA
                     IYKDLEDIENKKGEDKHE"
     gene            complement(39693..40025)
                     /locus_tag="KRO40_001063"
     CDS             complement(39693..40025)
                     /locus_tag="KRO40_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH2091892.1"
                     /translation="MNTQFRKGVLEICVLALISKKDMYGYEIVHNISKVIDVNEGTIY
                     PILRRLTKDLYFETYILESNEGPARKYYRITSLGKENLSNLMEEWREFVKAVEILISE
                     DEGGNELE"
     gene            40224..41345
                     /locus_tag="KRO40_001064"
     CDS             40224..41345
                     /locus_tag="KRO40_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactosyldiacylglycerol synthase"
                     /protein_id="HBH2091893.1"
                     /translation="MKDDKTILILTAQFGAGHISAAKAVKECIIEKYSNYNVVIQNFI
                     NASIPMMNKPMVKLYENNTKYTPGLYNYYYYFKKSFDSRHDLSHKLYTPKLSEYIADI
                     NPDLIISTFPLAAACVNNFKIKNPDINIPTLTVITDVVDSMEWVFENTDLYFVPSPEI
                     KNRFFQKGINPDSIKVTGVPVDKRFQIESKELCCDKYRLLLLGGGRGLFDIDEDFMHW
                     IDEFIEEHSNSIEITIVTGKNKKLYDNLTHKKPLKNIKVLGFVNDMYNLIRECDLMLT
                     KPGGATIFEAIQSQTPVLVKMPKVGQEIENAKFIIDKGLGMIYSDDLDLKNIFYKLVS
                     NEFDSIINFMKKNLKEFKTVIHPEKIADYISELIDNHYS"
     gene            complement(41473..43371)
                     /locus_tag="KRO40_001065"
     CDS             complement(41473..43371)
                     /locus_tag="KRO40_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HBH2091894.1"
                     /translation="MDSLLYVIEKDKHTNEELREILKSNKNIRFVSLMGVDLGGNATD
                     EKIPVELFLEDIDKFLESAIQTDGSSVELYNIATLNNAKVDLMPDKSCHWYVDYNMEY
                     IDEEVGLPVGTLKIPAFLIHDNKKVCSRGVLQKADKYFKKSMYEIFREYPHVINNIGI
                     DSVDDIEEIMLTAATELEFWVNTPEDKADLEKLYVSQSLKEQYWKRTHGIIRTCLEKS
                     LIILQKLGVNPEMAHKEVGGIQSSISIDGRTNHAMEQLEVSWKFSTPLQAADNELLVR
                     DVIEDVFTSHGLEVTFKAKPIHGVAGSGGHTHVGVSAKLKDGSIKNLFAPKDLKEDYL
                     SELGYGALMGLLYNYEVLNPIVTASNDGFNRLVPGFEAPVCIVTSLGHSYEIPSRNRS
                     VLVGLIRDMKNPKTVRFELRSPSPLSNTYLVIAGCYQTMLDGIKAAAKSGLSTKELEK
                     ELSKNVGEESFYLEKDRAYRDENDVFEHYSLEERNARFGIPPATVYENMKNLEIYASK
                     LKSLKQGDVFTDSIIESFKIGAIDKWQKKLKTRIIEAGIQKIRSIVKIHTKENMDALD
                     EVVWNSISDLKFNIMKDTLTRESLFTRVREAIENKDYQTASDLQIELKRSMEEIQQLY
                     MQYKKNIY"
     gene            43686..44462
                     /locus_tag="KRO40_001066"
     CDS             43686..44462
                     /locus_tag="KRO40_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH2091895.1"
                     /translation="MEYIIFDLEFNQGFDKKLNKTVSNEKCPFEIIQIGAIKLDSKFN
                     IIDTFNSYVKPTIYKDIHPFISRMTNIKSSDFNDSPTFPEVYNNFIKFISSQDPILCV
                     WGAGDLKELYRNINYHKLPSNSLPKSYINIQQHASKYFNNPAGKSIGLQNAISILELD
                     EKMSYHNALNDAYYTAKVFIKIYNPSIVPDIYLYTSIKPKTIRYSNKKRVDYDKLFDE
                     FRKILNRELTKDEKKIINLAYNMWKTNQFTLENVKQRKNK"
     gene            complement(44554..45306)
                     /gene="xth"
                     /locus_tag="KRO40_001067"
     CDS             complement(44554..45306)
                     /gene="xth"
                     /locus_tag="KRO40_001067"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HBH2091896.1"
                     /translation="MKFISWNVNGIRACVGKGFLDFFKEVDADIFCLQETKLQEGQIE
                     LDLPGYFQYWNYAERKGYSGTAIFTKKEPLKVMYGINIEEHDKEGRVITLEFEDFYFV
                     TVYTPNSQSELKRLEYRTRWEDDFIDYLTKLDNHKPVIVCGDMNVAHKEIDLKNPKNN
                     MKNAGFTKEEREKFSKLLDSGFIDTYRYFNPDKEGVYSWWSYRFNARKNNAGWRIDYF
                     CASKKLEDRLVSADIHTEILGSDHCPVELEIK"
     gene            complement(45467..46417)
                     /gene="galT"
                     /locus_tag="KRO40_001068"
     CDS             complement(45467..46417)
                     /gene="galT"
                     /locus_tag="KRO40_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HBH2091897.1"
                     /translation="MKELRIDPITNDVVIFATDRLKRPLDTADIPNEDEETNEYDEEC
                     PFCKGNEAHATDALFEIDSEEGWLVKSVYNKFPIIDDMARDVYGVHEVMIESDKHNRS
                     FYNMSQKEFEDVFFMYRNRFRDLSKDDKVEYVSIFKNFLRKAGASLMHPHAQILSMSF
                     IPPEITNELLVSKEYYDSNKSSLYDDLIENEISLDRRVVYNGEAFLVLIPYATKYSGE
                     VRIIFKDKIEFGELNDNNIQELSTIFEKLFKKLYNINGYMPFNLCIHTHPTKIETKSY
                     FNVHMHIIPRKYNFGGFELGTNMYVSSMSPEDLTKKLKID"
BASE COUNT        15439 a         7691 c         5146 g        18151 t
ORIGIN      
        1 tgtatactaa atgcatgtta aaatattatt ttaaaacatg cacaatattt gtacatattg
       61 tagacatata aacctataaa ttatacaata gtattgttaa gattatatat ttttttaaca
      121 taaattttgt attgggggaa aaacaatgga taaaaactat acgatgccaa tataccaaaa
      181 aatagcgttg gatattgcaa ataaaatata cacgggtgaa atacaagagg attcagtact
      241 atttggacgc tctgttttgg ctggtaaata caatgtatct ccagaaacga taagaagagc
      301 tgtcaaaatt ttagaggaca ttggcgttgt taaaagcata aagggtaaag gtgttattgt
      361 actatctcca gacaaagctt cttcttttat aaaaaaatat agagatatta caaatatatc
      421 atcatataaa tcaacacttt ataatttaat agatactaaa tctaatttag aaaatgaaat
      481 attagatact ataaataaaa ttttagacta ttctaacaga cttgaaataa tcaatccttt
      541 agtgcccgtt cagttcacca taaattctaa ttgcaaatat attggtcaaa cagctgcaca
      601 aactaaattt tggcaaaata caggtgctac aatagttgca attaaaagag gtgaagaact
      661 tataatatct cctggaccat atattgaatt tttagaagga gacattctct tagtagttgg
      721 tgaccaacac atttacaatt ctataccaat gtttttatat gaaaacgaaa aataaattat
      781 ataatttagt gtgattatat aaaaatgcaa gattaacaac aaaaaaagag cttcatattt
      841 tacataaagc tctttttaaa ttcaaataaa tttaactttg attaattttt aaatatccaa
      901 ttcatcttct ttttcccagc ttaaagctct cgatacagct tttttccatc ctttatataa
      961 tttacatctc ttctcttcac tcatatttgg attaaactct ttttctactg accactttga
     1021 agtaatttca tttcttccaa tatagaatcc aacagacaac cctgctaaat aagcagctcc
     1081 taaagctgta gtttctacta ttttgggtct atctatatct acatttaata tatctgattg
     1141 aaattgcatt aaaaaattat tattacttgc tccaccatca acttttaatg attttagttt
     1201 taattttgaa tcgttttgca ttgcttctaa aacatccttt gtctgataag caattgattc
     1261 caatgtggct cttactatat gttctttttt tgctcctctt gtaagtccta aaattgaacc
     1321 cctagcatac atatcccaat atggagctcc aagacctgta aatgctggca ctacatatac
     1381 accattagta tcctctaccc tatttgcata catttcacta tcttttgcag attcaattat
     1441 ctttaattca tctctaagcc attgaacaga tgctcctcca ataaatatac ttccttctaa
     1501 tgcatatgtt acttttccat caactcccca agcaattgtt gtaagtaacc catgcttaga
     1561 tttaactatg ttactgcctg tattcataag caagaaacaa cccgttccat aagtattttt
     1621 tgcagtacct tcttcaacac aattttgacc aaataatgct gcttgttggt ctccagcaca
     1681 tcccgcaata ggtattttag ctcctgataa catgcgctca tctgtatgac cataaacata
     1741 gctagaaggt tttactaatg gcaacatgct tattggtatg tccaattctc gtaatatatc
     1801 ctcatcccat tctaaatcat ttatattgta catcattgtt ctagatgcat ttgagtaatc
     1861 tgttacatgt acttttccac gagttaaatt ccatattaac catgtatcta tagttccaaa
     1921 taataactct ccttgttctg ctttttccct agctccttct acattatcta atatccattt
     1981 tacttttgtt gctgaaaagt atgcatctat taaaagacct gttttttctt ttattgattc
     2041 ttccaatcct ttatttttaa gttcatcaca tatttctgac gttctcctac actgccatac
     2101 tattgcgtta taaataggtt taccagtata cctactccaa acaaccgtag tctctctttg
     2161 attagttatc cctattgaag caatttcttc tggtcttata cctgctgttt ctataacttc
     2221 tctcattacc ccactttgtg acccccatat ttccataggg tcatgctcta cccatccagc
     2281 ttttggataa atttgattga actctttttg tgcaattttc actatttcgc cttttttatt
     2341 aaatagtata gctcttgaac tggttgttcc ttggtctaat gccattacat acttcttttc
     2401 catcaccata ttctccttat catataatat ttaatttatt aaaaagaaaa atttaatatc
     2461 acatatttca ataaataatc atacttaagt acaaatttaa tataatagat atttagtaag
     2521 aagacactta ttttctatca tatctatata ataatattat acattatagc ttacatattg
     2581 attaataaat tttaaaggag tataataaac agtgttcata ataattttaa taaaagaggt
     2641 ggtaatatgc caaagatttt agaaaatgta aaagaagata tattaaaagt gtctcgggat
     2701 atgattttag aagaagatta ctcgaatatt agcataagga aaatagctca aaggtgtggt
     2761 ataagtgcag gtacagtgta taattacttt aattcaaaac aagaaataat agaatatatc
     2821 acaaaatctg aatgggattt attgataagg cgaattgaat actccaataa aaacactgaa
     2881 gattacataa aaaaactaaa cattattttt actgaaataa gaaattttat aaacaaagtt
     2941 cataatatcc aatacaatga ctttttaaac acttttgaaa cagagagatt ttttgaaatg
     3001 aaaaaacaca aagacgactt tcatgaacag ctttcaaata aagtatatga agctttagaa
     3061 aaagaaagtt tttttaataa tgacaaatta gtatgcaata tcataataaa aatgtttttt
     3121 tcatattcaa catatcttca tatagaattt gaagatttaa aaccctatat tgaaaaatta
     3181 atacattaag gtggtgttta ccttgaatca taatactagt attaagaaca aggacagtaa
     3241 tccaaaaata tttttagtac ttacgcttta tctattaggt atatttatgg gagctattga
     3301 tactggaata gtatcaccag caagaacgat tatacaaaat agccttggag taaatgaaaa
     3361 aacgggaatt tggatgatta ccatatacac attaacatac gcttctgtaa ttcctatctc
     3421 tggaaaatta gcagataaaa taggaagaaa atatgtgtat ctagttagta tatttctatt
     3481 tggtagtggt tcattaatat gtggattatc atcactattt tccaatttct atattttatt
     3541 aattggtcgt gttattcaag caattggtgg tggtggaatc atgccaattg ctacagcaga
     3601 atttggaact accttcccag aaaataaaag aggcatggct ttaggtttag ttggggcaac
     3661 atatggtatt gccaatattt taggttcaag cattggtagc acaattctaa gtatctttgg
     3721 aactcaaaat tggaagtggc tattttttgt aaatcttcca atttgtttaa tcatacttat
     3781 tggtggagtt ttctgtatta aaaacaataa gtctgaatct aaagaaaaaa tagataagct
     3841 tggtacattg atgttgatat gtataatcgt atcactatta tatggtctta tgaatataga
     3901 cttttttaat tttaaaaatt ctatacaaga tatatcagtt tatccatact tattgacatt
     3961 tattgtactt atacctattt tcatatttat tgaaaataga gctaaagacc ctattttaag
     4021 ctttgaatat tttttaaatc cgagaatatt gatagtactt attttatctt taattgttgg
     4081 tattggaatg atgggtatgg tattcgttcc acagtatgct gaaaatgcat taaagataaa
     4141 tgctggttct gggggatatt ttgtagctat attgggatta tttgcaggta ttgctgctcc
     4201 tttaagcgga agacttattg acaagtttgg ggcaaaaaaa atactattac taggattttc
     4261 tgtatctatg ataggctctc tttacctagt tttaattgct ctaaaaacca atactgtatt
     4321 tagtgtatgt gtaagtttaa tatttatggg attaggaatg ggatttacta tgggaactcc
     4381 tctaaactat atgatgttat caaatacaag attagaagaa tctaattcag cacttgcaac
     4441 attatccttg atacgctcaa ttggtacttc aatttctcca gctataatga ttggatttat
     4501 agcacatgca ggattatctg tgcaagataa tattatggac ttagttggaa agccctcaac
     4561 tcctaaaata gttcaacttg aagaacttga aaacatgata gatgacttaa aatcagaccc
     4621 tgaaatggca aaaaatttaa aaaatgtctc tatcccaaat atgaatgata cttcaaatat
     4681 aaatatggac atgacaggtg gcaaacttcc aaaatcctta cttaataaag ttcagtcagc
     4741 agatacaacc aacattacca atataacaaa agaaatatca acaacaatgt ttgatgaaaa
     4801 agttccatct ataattacta aaatacagaa aaatgtacaa aaaggaatag atggaacaca
     4861 aagtggaata aacggtattg aagatggtga aaataaacta aatagtggta ttaaaggagt
     4921 tcaaactggt attgacaata tggtaaaagc tagagctggt attaatcaag gaatagatgg
     4981 tgtaaaaaaa ggtattgctg gtgttgataa aggtataaaa ggtatggaac aaggtcttga
     5041 aaaacaagat gaggccatca aggaacttac aactgcttat aataaaatac ctactacaga
     5101 aaaaactcct actgataacg aaaataactc aaatgaacaa aaccagagta ataccagtaa
     5161 ttctgaatca gacgacacta agaatgattc tacagaaaat aagaataaca attccagcga
     5221 gaataaacca aatgtaaatg aacaaaaaga aagtttaaat gctcaaatac agcaactaaa
     5281 aaagacaaga gatgacttaa atacaaagtt acaaaaaaat aaaactcaaa agaacgaatt
     5341 aagtaaaaaa ctaagatcaa tggaatctca aaagaaagag ctacaaagca agttaaataa
     5401 ttctataagc caaaagaaag acatggaaaa aagccttgat acaatgcaac agcaaaaaaa
     5461 atcactccaa gcagttttag caaagacaca agaggtaaaa actgaaatac caaaggcttt
     5521 tgataaatca aaattggatt atataaattc catagaaaat aatagaacaa aaatagaaaa
     5581 cacactacaa tctactctaa actcaggatt taaacagatg tatataacag tattctgtgt
     5641 aaatctacta gcatttataa tattattgtt ctataaagaa aataaaacta gataaaagag
     5701 tgttatagta ttatattgta aatttatctt attcttaaat attttattct aaagaataaa
     5761 ttcataaaat ttttgtaatt gattaatata aattacaata taatactatt tttctcttaa
     5821 tctttttctc ttttacagac aatcaaaaag caatcttagt ttatcgaaat aaatttatac
     5881 aatctattca tacacccctt tacatttata taacaattaa acctattgtt atatatacaa
     5941 atcaaaataa accatatatt ttcaactata atatgttaaa atcatattat gagcatatta
     6001 atttaagcaa aatgtcattt agactttaat ttagtagttt tatattataa atttatatat
     6061 ttttaatttt aaatgtcatt tagacattac tcataaaaag aaaggagtgt attttgtgga
     6121 tactttagga aaaagaattg cttatttgag aaactccaaa aaacttactc agcgcaaact
     6181 tatggatatt ttaaaatttg aaaacttagg caagtatgaa acaggagata gaaaacctaa
     6241 ttgtgatata ctaatgtcaa tagctgatta ttttaatgtt acgactgact ggcttctcta
     6301 tggtaaagag aaggtaaatg tcaatagtag tgtaaaagaa gataaagaag attacttaca
     6361 tgttactaat gatgaaatga cgatattaaa tctatacaga caactaaacg aacgtgataa
     6421 aataaaaata gaaggaatac ttgaacttaa gatatctgaa tataaagact taaaaaagca
     6481 ttcctctaat aataatgaag ataaaatggt ttaaacatac ataatttgat acgattttac
     6541 atcatctatt aaccttcttt ttttgtagta tattactaaa atatggatat tggattattt
     6601 aaaaacaagt atagtctaat ttcaagcaca tttataatat ttagattatc ttatccatat
     6661 tttagtttaa gtactttgaa aaatataata catctctatg tataacttat attcctaaga
     6721 aatgcattac tcatgttttt aattcttcca acatctttct atacacaatt gtacatcctt
     6781 cataattccc ctctttaaga aggattgaac atgtactaga atatttagtt aaagtattta
     6841 atctttccat atttaagctt tttatattac tgagtgctgt aataaaatca tcaattgctc
     6901 tacaacactc tataacccca tctgaatcca atttacacac aagaatattc acctacttta
     6961 tatactattt attaatcatc ttctgaatat tctatattaa gtaattgata aattgatgat
     7021 ttatattttt tacctgttct tcttccattt aaaatagctg acaaatagtt ttcattaaca
     7081 cctattttct tcgctaattc cctttgagtc atatttaatt caataagtct ttgcttgact
     7141 tgcactccca aaaaaggtat ccattttttt cgagcatcca tttatcaact tcctttctaa
     7201 gtgatttata tttactttta tattatttta gcttacacac cccctctatt tagtatatat
     7261 ttttaatatg tacacatatt aagtatataa atttatttaa tactaaataa gattttttga
     7321 ttactttgtg ctaaaattag gatgtaaatt cgtatcatta agttaattat aaagtcattt
     7381 tgaccttaag tcaatgcttt ttatgtcatt ttgaccttaa atttgaaact atttacatct
     7441 taaaaagtct ttttgacatt aattgaatgg agagtgttta tggatacttt aggagaaaga
     7501 attgtttatt tgagaaaagc aaaaaacctt aaacaatatg aactagaaga aatgttgggc
     7561 tgtgacaact taagtaaatt tgagagaaac attagaaaac caaattatga aatattaaaa
     7621 tctatagctg agatatttaa tgtttcagta gactggctat taaatggaga taatctatca
     7681 cataaatcag atttaatttg cgattcctcc tcaaactatc cacttaatag cataaactct
     7741 aatgaaataa agcttttaaa caattttaga aagttaaatg attatgataa agccaaaata
     7801 gaaggtatga ttgaattaaa acttcatgaa tatgaaaaag agaaggattt aggaaaaatt
     7861 gagtataaca aaaataaaga tgagaaaata gataaataat ttttatgttg cttttgatac
     7921 gattttacat catttctttg ttctaatatt tttatttcat ttattttctt ttttataatt
     7981 ttatgataaa ataattagta tattttgctt tacttgaatg taattattta tacaaaagtc
     8041 aaacataata taaatgtagt aaatttttag tttcaagtaa tatctcgtta ttataactaa
     8101 atatttatta aaattaggag gataaaatgg gcttaagaga caaattcgcg caatcatttg
     8161 ctagatcaaa aactatgagt ggccctgaga aaaaggctaa tgaaataatg ggtaaattgc
     8221 ttcttaagaa agctatatta cctatcgttt taatgttcgt gataataatc gctggagcta
     8281 tgcttaaaat caattcttgg gttacacttg gcataaattt agttattgct gttggtgctt
     8341 tcttctacat aagaaattct agtaaaaagt atcagaactt taaaccttat gttggcaatt
     8401 tgattagttt agagaaaaaa ggtaaaaaag agtacgttgc tattataaaa caaggtaagt
     8461 taccagttaa gttacaaata gcttatggtg gtgaagacct tgaacatgtt aagaaaaatc
     8521 aaatggttca aataagttat aatccagatg ctaaaatagc tattttggtt aatagacaat
     8581 aatttaataa aaaaaaggag ttgtcttaaa attgattttt tctaatcaaa tttaagctca
     8641 actccttttt taatttttat atattatttt tatatattat ttttattact ttttttaatt
     8701 aatattttta aatatcaaat ccttctcaat aaaatagggt actatctaca atactacttt
     8761 atcttttcct aacaatatat aatctggtgc tactctttca tgttatacac cgttttgtaa
     8821 catacctttt ataccagtaa catcttcctt aatttcctct acatctgttt tcattatacc
     8881 catttgaaca agtatatttt tgtttatttc ttgttgttgt gtagataatt ctataaaatt
     8941 ttctacagtt tttttataca tgtctctatc ttcttttttc tcctgcatag tatttttaaa
     9001 taatagagca catagtatac ctattgcccc tagactactc aattcggtta ttaatttatc
     9061 cattatagcc tcctattgtc taaatttttt atacttatag ctttaatttt tgttatattc
     9121 ttacatcatg caatattata ttttcaggat tatcaattta atcttctgta ctttaaattg
     9181 taggtgcaat ttatagattg aataaataat aaatatatat acaatttcta atataacaaa
     9241 aaataagtac aaggcttact tattaaagtt aagaccttgt actttacata aaaaaaataa
     9301 ctaatacata gttattctaa atttactatt caactggtat ttctaattct ttgcatctaa
     9361 ttctaacttg ctctctaatt actgctggta cttcttctat tgtttttttg cctcttaaaa
     9421 ttaaagctac atatacttct accattccac tctcacctcc agattttctt acactaaaag
     9481 agcttatatt acttgcttca ttgacagaac tttgatttaa caacatctca tatatttctg
     9541 catttgctat aaaattattt gttatatcat catcttgctt tacttgacct atacttatgt
     9601 ctgaaatgtc tttatactgc atttctactt ttctaccttg tttgatttgt tctattttat
     9661 ttttatcgaa tttaaacaat tttcacacct ccattttaag cttgtggctc gttgctttca
     9721 gcatcatatc taaaaatcat agatggacgt tttatagctg tccatttatc tcctttttct
     9781 actatgattt taggctgagc actttttatg ttggcttctt ctaattcata gatttcttgg
     9841 taacttgagt ctgatttttt gatttcaact agtttcatgt ctttgaataa gtcagattta
     9901 tttattttta cttgaacttt agttttattt attaattgat atataggatt gttttccatc
     9961 atgtcatcct ttaatccctc atttaatgtt actattaaat cagtgttatt ttcagtaatg
    10021 tttatgattg aatatacttt attgtttatc attaaaatag aatccttttt tactttaagc
    10081 cctgtttctg atttaaatat aaacatactt gaatataaat cgcctgtagg actactggct
    10141 ttaatcagta tcttattttc tcctaatact attttatttt gtggtatctc aaatataatg
    10201 ctatttattt ccaaattagt cttagtagat attaattcat catttataaa catttcaagt
    10261 ttttctataa cattattagg gtcttgtact acaactctca cttgagatat tgatttttca
    10321 actatttcta tagatgcttt acttgtatct acttttgtta tcatgtatat tgtatcatct
    10381 gaaagctcta tatctaaaat atcatttaga tgttcaggaa ttggtatttt agtaaattca
    10441 tataaatcag taattgatat agatatttta tacatagatt tatttttacc agttatccat
    10501 agactattat catttttaat tactagtatg tggtcatcat tatgtgactt aatttcttta
    10561 acattagtta atactttagt aaaagttctt attatcttat ctttttcact ttctcctagt
    10621 ccaaataatc catttgtatt gtacccttga gcgtacaact ctccctcatt agttaaaaca
    10681 agtgtcattg agttatatat acttatatct ttaacagaag gtaatccagt aaccttttgt
    10741 aactctctta catcattatt gtggccaact cccaattggt actcagtatt ctttccatat
    10801 gaccatagag tattatctgt cttaataata taggagtagt tatctccaca agcaactttt
    10861 ttgacatctg atatatttac ttcagtaaga gttaataatt ctatatcttc aagggtttga
    10921 ttaatttctt tatatgaatt acttcctatt ccatataact tgccatcctt agcaacagcc
    10981 aatgaatgtg tttttgatat atcaatatca gatacctcaa atggcaatat tattgaagta
    11041 tacttaaaat tatctttaaa tatgttttta taatttatat acttattatt tgtttttata
    11101 tacttatcat taaacattac tagcttttca tttttcttat taaaaactat tttatctgat
    11161 gtgttatctg ttttaaaata tgaatgtagg gaaccttcaa gagcttcatt tttatcatta
    11221 tcatatctat ggtgaatacc taaatgatta tatctattat ctcctgttga agaataaaat
    11281 tttccatata tatctttaat aaatatagta ttgtaactag aaaatacagt atcaacatct
    11341 ttctttatag atactttata atatggaact gacatatccc tataagattc atcagatata
    11401 ccataagtat ctctacctga tgatatcaaa ttgttattat tatctatata aagtgtatta
    11461 ttagctgtta caaaaacatc tttaacatct tccacactat ttgtattatt attatttgct
    11521 atacttccat atccactaag acctccaaca aatagtttat tgtcatttgt taaaatggct
    11581 gaagtatatc cattaactac tatttttttt gcatttataa tattattaat tactcgtata
    11641 ccctttatat cattagtttc tgttgaaaag aataccctct cttttttccc tgtagtataa
    11701 ataacattgt catttgttat aaaaaatgta gcttcacttc ctgctgttac aacagatttt
    11761 acattctcaa tatttatttt tgtaaatgta cttatacttc cttcagtaaa cccaaaatat
    11821 ccatttacaa atccacatac ataacatgta ttatcatttt taacaattat tgatacatca
    11881 ttacatatat acacatctct aactccattt ataggtatac gtgtaaatat attcctactt
    11941 gtagtatcac ccaatcctaa ctgtcctttt ccattattac ctgctccata taaaagacca
    12001 tcattagtta ataatagaga tgtgtttcca tatacagcta catattttac attttcaaca
    12061 tttattttag taaatacatt tctatttaca ttatctccta ttcctaactg accagaatta
    12121 tttaaaccaa cagcataaca ggtattatca ttttttatcg caaatacatg tttactattg
    12181 tcagtaaatc tatttacatt tatagatttt atattatcaa tatttatttt agtaaatacc
    12241 tttctattta tctcatctcc cactcctaat tgacctacat catttaaacc aacactgtaa
    12301 agcatattat tattagttaa taaatatgta gacttcgaat ggctatatat ttcttgtata
    12361 ttagaagata tttcactact gctattcttt ttattgtaat ttatcttatt atttaaattt
    12421 aaactactat taactgatat accatgcgta cccttagagt tatatccaca tataaataag
    12481 ctcttatcag ttaatattgc aaatctagtt ttatctctac ttaaatcata aggaggtata
    12541 aatatatttt ttatattttt cattaccttt ttataattag tggcattata tccatcttgt
    12601 gtatctgaaa catctagttc ttttgcactt tcagatatat tcccaaaacc atataacgtg
    12661 ttagaagata aatacaatag agctttatat aaaaatatgg ctttatcaga ggtaatagga
    12721 cctgaattta tattagatgc tgcaatatta ttagatgatt gattgttaag ataattcctt
    12781 ccatattgat gtatataaga tgaacctcca gaaataagta aattatctgg atttacattt
    12841 tttaaattac ttgttgattc tccataatac aaataggcaa aatttgtaga atatgatgat
    12901 tgtgtacacc ttgtgggata atagttatat atgtaattac taatatatcc agcatgtgta
    12961 attccttgtt gttgaactct ataagtagaa tcacttggct ttgtccataa agtaccatgg
    13021 tatccagtta aaaaagaacc ataatttgta cataatatag ccatatattc atatataata
    13081 atattattaa ttttagtaat atcatttgta caagaatttg tactataact tgctcctgaa
    13141 ggatttacat aaaaccagtt atttattaat gttaaattta tattgactcc atcattagga
    13201 ttaacaccca ataaatagtt tgtatttata ccagttgcat ataccttttt ttcgtcagcc
    13261 acaataaatg ttgcattata tgaactatat gcatctgtta cattgctaac accaatctca
    13321 gtatattgac ttgctgattt attactaagt ccattaacat aacttgaact ctttccagaa
    13381 gtatatattt gcttattatt agttacaatt aatgaaaacc agtttgataa atcagtattt
    13441 ataacaactt tttttacatt atctatagat attttcttaa atatatctga attagaagga
    13501 agaacacctg ctattgagtt actatttggc ccagaataat aacaagtgtc atcattttta
    13561 atgtagaata ttcctccaga aatatttttt gatgctacta tagactttac attagagata
    13621 cttaattttg tcaactcatt taattgactt ggtaagtcag aacccattcc tttgtatcta
    13681 ttatttccta gaccatatac atctccattc cctaaaataa ccagagtaca ataaggacta
    13741 aaaacgacat ctcttacaga atgtatatct agtggaagtt caatatcctt tatttccatt
    13801 tcttctttta ataaagttaa tttatcctca gatttaatta aatttatata attactataa
    13861 ctatattttt cactatccat tttcttaaat tctacaatgt gcatatcatc aaaaaacgaa
    13921 cctaattgtc cataagtatt atctcctgta caatatgaat cattatttga atcaattagt
    13981 atgctatgtg ataaaccaat gaaaatattc ttagctacaa tattttttaa atctataaat
    14041 gaattatcta tattctcaga gtaatttgct atacctaact gatatatatc attatttcca
    14101 gcaaccttta aagtaccttt gttatctata agcatagtgt taccatgacc acatgcaata
    14161 gtttttatat ttacttcttc tatcttagta aatagtgatg attgaagtgc atttccaaaa
    14221 catttttcct ttccacaacc atatatatca ttattatacg tcattaacac agtgtgttca
    14281 gaaccacaag ctatagtctt aacatcatta atagaaacta aactaaataa atctctatta
    14341 ttcttatctc ctaaacctag ttgaccttga ttattaaaac cagtagaata gcatttattg
    14401 tcattcttta ttataaaagc tgatttatta tatgaaaata cagcctttac attgtcaaca
    14461 tctacttttg taaatgtatt tacatttgca gatgctccat tagttcctag acctaattga
    14521 ccatacaaat tatttccagc aacatataaa gttccatcat tgtataaaag atatgttgat
    14581 tgaagtccac atgcaatatc ctttacgcct tttatttctg gaaccttctc aaatgtagaa
    14641 actgttttcc ctactttttc taatcccaat cccatttgac catctgtatt tatacctgcg
    14701 acaagtaatt ctccatctga agtaagtata actgcatgag attctccaca tgcaactttt
    14761 ttaatattgg tagatatatt tggtattttc gtaaataatt ttcttgttgt attgtcttct
    14821 cccaatccaa gttgaaagtt actattatct ccacatccat acaagatatt attatttttt
    14881 agaccaaatg tatagttaca acatccagta aaaaaattaa taaagtcata attatcatac
    14941 ccttcatcaa attcatcaac taccatattt ttatcgccaa agaaattacc tctttgaagt
    15001 agtttagttc ttttcattat aaaaacctcc taattatctt atttcatacg aatatttatt
    15061 taaagttata tctgtctgac caattgaata tgccctatta gattttgttt caacaaagtt
    15121 attatccatt tcatgtatat atctaactct atttgcatta aatggtagca ccacattctt
    15181 aaatgtaaca ctaccaagtt ctccagttat acactttcta tttaaatcta acttaaggcc
    15241 ttctatagct attatgtttt tagcattagt taaggtatca taccaatatc cagcttcatc
    15301 tacatctatt tctgactcta attctaagta tattaagata tctaatactt tttcagataa
    15361 tttattgtaa ctatttttta atacagatag ttcagtttgt atttgacctc ctattacatc
    15421 atcaatagat atatttttaa ttttttctac tacctcattt atagctcctg ataagttttt
    15481 agcttctgta gataagagtt cttcgccaat ttttactttt atttctttta tatttttatc
    15541 aaacttatca tctaaatctt gaatatcctt ttgagttaca aaaaccaacg tcgggtctac
    15601 ttctaatgta acatttgaag tattggacaa ttgtaaaatc atttttacaa ccaaatcttt
    15661 aatactgcca tcttcagcac gtggcttata cgtctctgga tacttaccta tagctattat
    15721 attattctca ttatccagaa cagcagcttc tcttatcata aatccaccaa ctgttcctgg
    15781 taaaatagtc tctataacta tccaattagg atttttttca tcaattctta gagaatttat
    15841 atttccttcc caaactacat tctttaaagc agtttgttcc tctgttggct cataatattc
    15901 tccattacta tctccaactt gaaacttggt taatccaaca agctctccta gtgcagttgc
    15961 atttgctatt ttttctctac caattttggt taatattata taaaattttt cttccaatta
    16021 taccacctcc gatttaggat aaactactac attttctaca cctgtatcat ttgcaatagc
    16081 tatattaatc ttacaattat tttcaatgca tttaatgctt aaaggataaa cctttatttc
    16141 ttctctactt atcattccag ctccacagtt tacaacagca ctacatttta taattggttc
    16201 aaagtatgga tgaactttta cctcttcact acataccata cctccaccac aatagaccat
    16261 acttttatct agtattattg gttctaaata gtgtaataag tgagcaggtt ttactctttc
    16321 aatcatatcg ctacaatcta aaagagtttt atagtcacag ttatttgcta taaaactcaa
    16381 tacgaatgta aattcatcac tataaacttt tatatctgtt tctgattttg tatatgcctc
    16441 acatatactt tttataactt caatagtact agtacctctg cttctcattt tagcttttat
    16501 attgctacgt cttgtgtcaa aatcaagttc ttttttttca atgcagagta tgtcttccca
    16561 catatctaat ccccatgttg cagtgtcaac aaataattgg ttaaaggtat catcaatatc
    16621 ttctttaaga atatttaatt ctgtatcgta tgcaccttgt atctcctcta caatgtaatt
    16681 tctatcaaat gatggtagtt tatcaattag cttcattgat tttccacctc actaaaatta
    16741 acagttgtta cactaggtat tttatcttca ttaatagtta tattatctgt acttccattt
    16801 ataagtaggt tacttaaatc gtgtacacca gtagtattta taagtattcc cattactttt
    16861 gtatagatta tctctcctct aatatctcta aagtatgtat ttatactttc taggaaagat
    16921 tcttttacat tgtctaatgt atatccatct tctagtttca ttactgcact tatacttatt
    16981 tctattggta atggtgtcac aactgttata gttggtccaa taggcttctc ttcatctata
    17041 tgttgctgac acctttcaat tgtttctgta tcaacagctt gattattttt cccaaatatc
    17101 aagaccttaa ctgttcccgg accatcccat cttggataaa ccttaacatt atagactcca
    17161 tctacttcca aagcccattc ttcatagtga gctttatttc cacttgtagc ttgatttctt
    17221 tggattttat aaaatctttc ttttagttct tcatctgtct ctatatctgt accaccttca
    17281 aaacttcttg tgttagtaat ctttgttact ccagatatat tatcaactag tttaaattca
    17341 caatttgtag gtaaattata tttcttacca acttccagag cttgaactgg gctattgtca
    17401 ccttcttcac taccaatagt tacatctttt attactacaa atagtaaatc tctatatgat
    17461 attattgtgc cattatttat tacagtacct ttctctccaa taaattcaac ttctccattt
    17521 gactctgtac ctaactttct atatacacca aattcattga ctcttttatc aagaaactgg
    17581 ttatatgtgt cttgtataaa agccatttta tgcatctttg aaagttctag atatatcttc
    17641 gaaagttcta gattatttcc agataccatg ttgtttagaa aagaaccttc tcctttataa
    17701 atatcaagat taatattttc aagagttcta ttttttatta cttcatatgt ctggtcacta
    17761 tacatttatt tccacctccc catagatagt ggatactttt acatttgcac tcaatatgtc
    17821 tctgttaaag ttagcacttt ttacgtttac ttctaatata tatggattta ttagaagggc
    17881 ctcttttatg aatctactag cttcactttc tgtaagacct tttgtatatt tttgtcctat
    17941 tagttctgaa agctctgtcc catattctaa agagtatatc tcatgttcat atctatttgt
    18001 ctttatacac ttgtatatcc aaacttttaa ggcttctttt ttttcaatta ttttaaagtc
    18061 acctttttct aaaataggtt catctttttc aaaatcccat gccacttcac gaaagattgg
    18121 caattcttct gttttaggta agatataatc ctctgggaca cctataaaag gaaatattgt
    18181 actcattata agctcaccaa cttacttaca acagcaaatt tttcgcctat tctaaacatt
    18241 attaccatat ccccagattc aaagttatct ataaaaggat tttttacttc atgctggtgt
    18301 tcttgatttg tttctgtgtc aaatgtttct agctgtctat caatcatcca actatctatc
    18361 aaaatatctt ctttttctaa tatgatgtta tttgtctcta tttttaaatc tggtaattta
    18421 cttttaattt ttccaataaa aaaagaaggt tgattatgat actttccttc ttctcttatt
    18481 attcctataa attcatttat tggattagcc attatatcac catcctttta taatactctc
    18541 ctagctgtgt taaaatctct tctactactt aacttactta ttttaactac atcacctttt
    18601 tgtggagcat gtaaaaattc tccattacct atatataatc caacatggct gactggatta
    18661 tgaaaaaata ctaaatctcc tgcttgaaga tttttttgtt ctactttctt gcctttttta
    18721 gattgttgat ttgacgttct tggcaaacta acattaactt ttttaaaaca atagaccatt
    18781 aaaccagaac agtcaaaact acttggtcca tttccacccc atttataagg tttacctaga
    18841 tgtttttttg cttctgatat tactatttta gctttatcag atacattacc agaataacca
    18901 ccaataataa tttttccttt tcttcttcca aatttactag cttcttcaac atttccaaat
    18961 aaaatatcta tatggtatgt tccattcttt tctatagtta ttgcaggtcc tacgtcattt
    19021 actttataga ctccatcacg accagaaact cctgtaatta cctgtatttc atctccatag
    19081 tttaataaag gatgtttatt taaaaactct tttgtataat aagtttgctc atatttacca
    19141 accataggag cagcgcaagt ttttttagat gggtcaagtt ttttctttct acaatctgta
    19201 tctccacctt cttcttttct aggacagtaa gctgtaaatt ctgctgtaaa ctcttttcct
    19261 cctgcataat cttctccccc taaattactt tcttccttag gttcatcctg tcctgctgac
    19321 ttttcatcca taagattttg aaaattaagt tcaagctcaa tttgatattc tccattttgc
    19381 caagtatgtt tgtctgtatc tatataaaat agtcctacaa gctttgtata agaatcttta
    19441 acttttactc ctctaccagt tatacaactt acatctccat aacctttaag agaacagctt
    19501 ttttctatcc cattaaactc gctatcaata tctacatctt gattttcttg ttgctgaatt
    19561 actttttgca ttattacatt tacttcctta aaaatttcat tatctatttt ttcgctaatc
    19621 ttgcttccat actggtctac cactattact ttatttttta cattttccat gctctccgaa
    19681 aaggtggtat ttataatatt aaatccctct tcaaacataa cacttaatgt aacagttcct
    19741 ttttcaataa cattaaactt atctaaattg gcctctatca tatacttttt ctttgtcttt
    19801 ttacttgctt ctgtatatgc actcattatt gtgtcataac catttactcc tataaacatc
    19861 tttgtatact tgacattggt ctttgctatt attccaactg aaagcctatt ttcagcaaat
    19921 acttgctttg ctatgtcttc aactaactta tctttaaaat tgtatgacac ttcactttgt
    19981 gtaagtaaaa atcccatatc tttagataca aaactaattt cattactgct tgaatcttta
    20041 gacctattaa ttatcattcc tctaaagagt tctttctcat ctacatagaa acagactgta
    20101 ctagctattg gtatatcgat ttgttggaaa tttacatcaa atgatgattg tattattgaa
    20161 aactctagtg tccttgatgg agatttataa tcacctgacc atgatacctt gtctactatg
    20221 tcagttatgt catatatact tccgtttttt atgtgtaccc aaatcttaat aataaaaaat
    20281 cacctgcctt ttcatttaat tctatcagca gttatttata acttattatc tataatagtt
    20341 attgttttgg agttactttt ggtatcttta ttcttttata ctcttttaaa tctaatgtaa
    20401 aatatacatc tcgagtccca tctctttctt cataactaaa cccttcaatt atgacttcca
    20461 tatttatatt tgtttccgta attgtaaatc ttaatataaa accttccttc atccattttt
    20521 ctatcttatt tacacaatca tatggtgatg gaaaacctgt atagtcacag aaagtatagt
    20581 ctttatttgg aaaaaaactt gatattgaaa tgcttttaag agctacacca ccaaaagttg
    20641 ctatttcacc tattttgagt atactagaag agtttacagc agcttttcca ttaatactaa
    20701 aggaagatgg aaatactgga aatctaaatc tatcttcagc ttgtctaagc cacatttcca
    20761 ttataagaca ccccctaact gtgccaattg gatacttgca actaattttg atgttatctt
    20821 ttctatatca gcttcttctc taatcactat tgtatcagct aacttagcta tgtttatatt
    20881 tccaccattt tttctgcttc tatattgatt tgcttcttgt ttagttaaaa ccatttcacc
    20941 ttcatggagt ctggtttgat agtcattata aggaacatag ttcaatccaa atgcattatt
    21001 acctttctta cctgaataag ctttaccaga atcaccagcc tttgttccag catatggatt
    21061 atctttgtaa ttttttttac tcttttccac tagatttaaa actgttcctg tgatgcttcc
    21121 attttttatc ttattaatca tagtttgcca ccatttacat atatctttaa ctattttaca
    21181 tactttatct aatatgttaa aaaaagctcc caatattggc tctataattt tccatccagt
    21241 ttccaacaga ggtcctaagg tctcccatac agttttccaa ataacaccca gtgtctctat
    21301 aaaattgttt atttgaggtg catattcacc taaaaaagta aaaattcttg tgataatagg
    21361 actaacagct tcaactacag gtccgattag ttggaatgct gtagttacta ttgtaccaaa
    21421 tatacttatt aatccttgtg caattggtga tttattgttt atactatcta gtaaattatt
    21481 tactaagttt actactggaa gtaatgaatc tattaatgct gtaaaatcga tattttgtaa
    21541 tagtgtactt cctgcgttaa caattgcttt tggtgcattc cctatcattg ttgctgcatg
    21601 attttcaaaa cgttcttgct tattttcaac catcatttta cgcttttcag cctcattaga
    21661 aattcgatat tgagtagaat cagaaaactc ttttccattt tttacacttc tagattgcat
    21721 ctggtcatat ttgttgccaa taattatctt accattcatt acattgccta ttttaccagc
    21781 cattttttca gataagccag ctaaattgcc taatccactt tctataaaag tttttatttt
    21841 ctttagtcct tgacctaaaa tatcatcaaa aggtttaaca atactcttca agccattgtt
    21901 aatgcttgtt tgagctcctg atattatacc tggtattgta ttactcattt ctttagctaa
    21961 ccccatctgc tttacactta tgccttccaa tgcttcatca aaagttttat aattttctcc
    22021 taccagagta ttaagagatt ccatgtttcc ttttgctgca cttaagaaag ctgctgatac
    22081 atcttgttca ctacttgtat tcatatttaa agctctaaca tctaccatag cttgagttat
    22141 atctttttct tttttgccac cagtaatatt actaatcatt ttagctttag ttcccattgc
    22201 aacaacatct tcagggtcaa aaggcgtatc atttgccatt cttactaaac tgccataata
    22261 atcatcaaca tctatttgat taacttttcc agtatttctt ttcattacac tttctagaac
    22321 aactttctga ttttgttcct gaccaagtaa atcaacaccc tttttcacag cgacacctat
    22381 agtagcacca tttgtcaaat cagatatctt cccttttatc gaaccaagta ttccacttgc
    22441 catatccttt acagctattg caccactcca taccttacct gcaaataatc tcaatttggg
    22501 aaatacttta cttataatgc cacttgccat atcttttata gctattacac cactccaaaa
    22561 agtattttta aacaacatta acttaggcaa aattctaccc atagcactac tcaccatatc
    22621 tttaagatta atacttcctt gataaggacg tttctctact tgttttaatt ttcccaagat
    22681 actacttatc actctcttag tcatatcttt tgcttttatt acgatattcc aaatcttgcc
    22741 accaatcttt tttaaatttc caagtaattt atttttagtt ttttctactt catcactttt
    22801 agctttaaat attaatataa tcataatatt tgaattaaac tcatttttct tttgaatcaa
    22861 cttattaaaa taatcaataa tcatagctat agttattgct agtctcataa tacttccatt
    22921 taaacttcca ataactcctg aaacagcatt tatgctagaa cttaattttg tcatagttga
    22981 acttacacta ctagcagtag tttgaacttt tcttaacgag gaatttaaac tgtttactct
    23041 attacttgca cttccaatag aattttttat gctactagcc attacattag tggaaagtga
    23101 aacagccaca gttgctctcc taaaattatc agttactgat ataatttgat tcatttttgg
    23161 tgtgtaatta tctgtaaggt acatatttat accttcttct ctcacatttc ccattacata
    23221 ccacctcctg tcaaaggaca cactccatat ccatgtttca ttttttcaac ttcttcctca
    23281 atttctaagg cgaaaaaagc ttcaataagc tttaattcgc ctttatccat tgcataaaaa
    23341 agggacggtc ttataccttt tttcttccaa taatagtaca ttattgtagt cctggtatcc
    23401 gtccctatta gttttttacc tcttctatca ctgcattttt accataaccc ataacatctt
    23461 gaagtattct atataagttg gtaatttcac ctggtaataa taattttctt gctaattctt
    23521 ttggtgttgg agccttaaat ttatccatta gctccttatt tttaaataaa agctttccat
    23581 ccaaatcaca aacaccttct ataattgtaa gcatctgcat ctccggtaag tctatatccg
    23641 ttttcatatt ttcatcaatt ttaagacaag tattttgtat ttcttcatct ttacttattg
    23701 ttaaagctct acacattact ttaaattcct gcccaaatat agttgataat ctcttaagtt
    23761 caactatagt acttggtctt tctaagtttt ctgtatctga atttaaaagt aaatctacta
    23821 tgtttatatt ttttgataat ccattttcac tcattattat ttgctccttt atcaatcaaa
    23881 ttcaatcaac taactttttt acttattaac tatctgaatt tattaagtat atacttacta
    23941 aatatcagta taaaactaaa tataaaacta aattatatca agaaaatcat actcagtaaa
    24001 tgtgaaagga gcttctatct ctccttttac tccaacctcc caatcagcta aagttaaatc
    24061 atcaaatgct atatttttta ctgctattct ttctgctcca taagaatctg ggtcatttaa
    24121 ttttgatata gcaacaaatc taggttcaga acctctcttt atcttttctc caattaactt
    24181 gtgcattctt gaactaacgt ggtatagagt tattgagcct tttcctttat atcccatata
    24241 ctttgtatca gtacccattt gacctgctat tataatatct tcttttgtaa attccatctt
    24301 tgcttgaaat ttctttactt ctgctacttt gtttccatca agccaaagtt ctccccaagt
    24361 accactcatt acatttctag cttccatatt tgccatatta ataatcctcc tatatttcta
    24421 ttgataaatc tatatcttcc atagcatcaa gtacttttat ttttgctttt aaaaatactt
    24481 tagaacctgt gttagcttct tttatttctt gtaatgtcat ataagataaa tctactcctt
    24541 ttgattttaa atacgatttt tgtgcttcaa aatctatttc aacagtagaa tcagattcta
    24601 taagtgctga tttttctaat tcttctaaat aactttttat agctactatc aataaacatt
    24661 tgttgtcata actgttagta acctttccta tatagtcatc tattatcacc tttcttatgt
    24721 cactatgtat aatatctaaa gtgtcaacta tttttatttt ctggaacatt tctccttttt
    24781 ctgctgttaa ttcagttaaa gaatttactc ctctagcaat tcttatagct cctgcttctt
    24841 taataagtat aagctctcct ttattaaccc ttgattctgc atcaactttc gtcatcttag
    24901 gtatatcgac tacatcacta agtttagtat aagttactga ttgacttaaa ggtgtacctg
    24961 ctataagtcc agccaccctg cttgtaaact catcaacact gtatttcttt tctccaacta
    25021 acacatcttc tgtagtaaaa ttaattatcc cttcatgatt tcctacaact tttcctaata
    25081 cagctttaac cttaacctta tctatatctc taagtttaat tatccaattt tttatagcag
    25141 tcttatcagc ttctactgct tttggcatac atagataatt aaattcctta gtctctaaaa
    25201 aatctaatgc agtttgaata tctgcttctc cttctattac ataaactaat aatttatttg
    25261 gagtgttaac atttcccatc aaagctaaat ttatatattc tttattttca gcagataaat
    25321 caactggtat atcctctttt tcatgtattt cattaagacc tagtgcctta gcatctttaa
    25381 gtaccattgc aattattcct ctagctgaac gttctttaac agttgtagct agctccttaa
    25441 atgatatgtt gatacttggt aatcctatag ccatactatc actctcctaa atttaaattg
    25501 atttctttca tattttcata tactacatct tcttcatata cactatccag atagtttagt
    25561 gtaaatgtaa agttcaatac ataaattgac tcttcttttt taatactttg ttctagcttt
    25621 gttatattta attttctgtc tgttaccttt atatttctgt taaatagctt atttaattca
    25681 tctgaaattt catacattct aatactcttt gactgtggtt ttggtaagta ttttatagag
    25741 ataacaatat ctttgttatt cgtatttaac attacaggtg tacaaataac tgatagtata
    25801 cttacaaaaa aacaagaccc ttcagagcct tgcacacttt catcatcaat aaaaatactt
    25861 tcagtaaagt tttttttgag aatctcaata attgtttcta atatttcctt gtatttaagc
    25921 aaataatcac cacactatca ctaaatattc ttgcttaatc tgataatctt actataaatg
    25981 atataagtca tttttaaata tatatctcat ttattcctgt caagtatctt ctatattttt
    26041 aggtaatatt attcttttca atctatcacc tccttcaata tggatttctt tcacaataac
    26101 attatctcac atattttatt gcctattgtt gcaatggtgt atataaagtg ttgtaaaatt
    26161 gtcctatttt ttataatatc tcactcaatt taaatatcat ctttttcttt aaattgtagc
    26221 aagatgttct atctaagtgt agtttcatag aaatatatgt catattgttt tttgtcttac
    26281 tattataaaa aagattaaaa aattccattt ctatatcatt tagacacgtt agagcatttt
    26341 ctatcttctc tttttctatt tctatatctt ctttttccat ttttaatttt cttaatcttt
    26401 cctctctttt taacacctca ttttccacag aagagcttat gttatatgtg ttactagtct
    26461 tttctgtata taccattgct ccacatccag agtattcatt ctcacatctt tttatgtcca
    26521 agttaatatt ctttatcttt atatccaaat acttataatt atgtaatctt ttatctgttt
    26581 ctttaaataa tatatctttt ttgttttcca tagtacttcc ccttttttat atacttatta
    26641 ttagcttcaa atttacaata atctctttag tgcacagttt tttactaatc tcacaacttt
    26701 caagaacata ttgttctata actgtataaa aaaaacttct tctatatttt gttctaaaat
    26761 actagaaatc ttcttagcca taagaagtcc aggatttttt atacctcttt ctatttgaga
    26821 tatataatca tttgtaattc cagcctttct ggcaagttga atttgtgtca tacctttgca
    26881 ttttctataa tatttcaagt tatttttaaa cattgtttta tacctccatt actattaaga
    26941 atattttgtt cttcctcact tagattatat agaattattt gttctttatc aatagatttt
    27001 agaaaaaaat attcttttat attttattag ttttattttt tagaacaatt tgttataatc
    27061 tatacataag gtggtgttat aatgtttgcc aaaagattaa gagaacttag aaaggaattt
    27121 ggattgactc aaagagaact tggagaaaaa gtaggcgttt cccaaagagt cttagggtac
    27181 tatgaaacag aaaacagatt tcctgatgaa cacattttaa ataaattggc tgatgtattt
    27241 aatgtatcag ttgattacct tcttggaaga accttagtta aggaaaatat tgatacagta
    27301 gctgcacata gaaaaaatcc acatgaagag ttacctgaag aagcacaaga acaacttaat
    27361 gattatatag aatttttact aaataaatat aaaaaaaaat aaaccatatg atgagcagtc
    27421 tatttttctg ctcttttaat ataatttaaa ggcaaacata cattctattt tagggggatt
    27481 tttatgaata atttggataa gctttttgaa ttagcttctc aagaagagat aataattcat
    27541 tataccactt atattgcagg tgatttagaa ggactatata taaacaaaca tggtattaaa
    27601 attatatcat tactcagtaa tttaaaacaa aactcaaaaa aattgacatc catcttagct
    27661 gaagaacttg gacatcattt cactagcctt ggatactatg tatcctctta taacgattat
    27721 tatacaaaaa ttattataga taagtgcgaa aataaagcct taaaatgggc ttgtgagttc
    27781 ttaattactg aagaagatat aataaacata attaactctg gcatcacttg cgtttatgaa
    27841 atggcagaca tacttaatgt ggatattact ttctttcaaa aaagattaga atttctatca
    27901 ttaaaaaaac agtctttaca acttggaaat aataaatatt taatattaac taatttgccg
    27961 tatttctaca tatttgatcc aatttcataa taaaaatagt agtaatttta actggcttaa
    28021 cagtaaaatc tatatattta ttttaacaaa ttttggtttc tataaattca atattaatat
    28081 ataataatga tatcatatta tttaaaattc taaaaacaaa tatatgcttt tgttaagaaa
    28141 ggttgtttga tgaatgtata aagaaaagtt gtttgataat tattttaagt tcttagcact
    28201 attattttgg ccaattatgt ggtataagtg gatagtaatt tcaaatggta ctcttgaaaa
    28261 tatgttattt accatatatg caatcgtcgc aattgttttc atcattttat attcggtgtt
    28321 tatgataaaa tataaagaca ttacacaaat agatttcttt tacaggataa gtactctact
    28381 tgcttttata tttacacttt ttagcttttt aatataccca aagagtttat ttttcttgta
    28441 tttaaagatt atttttactg gaatatacct ttattattca atagtaaaaa ctcttaaatt
    28501 taaagatgac gaaggtgtag tgggtattat gagctcactt ttattaattg taataacttt
    28561 gttctactaa atttaattct atttgactta atatggcttt aaatattaga catctacatt
    28621 attttctgat attatttaag atggtagtct tatattaata atgaaataca ctatgaagga
    28681 gttaactatt atggaaaaaa aagttttagc aacagttgga gaaaaagaga taactaatat
    28741 tgatattgaa aatgcattaa aatcattaga cccttatcaa gctatgcaat ttaaaactga
    28801 agaaggaaaa aaacacttat taaatgattt agtgaatcaa gaattattct tcttagatgc
    28861 taaagaagaa aaattagatg aagaagaaat atttaaatta gaaatgaaaa agatagaaga
    28921 aaatgtatta aagcaatttg ctataaataa agttttatct agtgttaatg taacagaaga
    28981 tgaaaaagta aaattctttg aagctaataa gagctctttc tctaaaccag aaagtgcaac
    29041 tgctaaacat atattagtag atagtgatga aaaagctaaa gaaatacttg ctcaaataaa
    29101 atcagaagaa atatcttttg aagatgcagc tcttaaacat tcttcttgcc catctaaaga
    29161 tatgggtggt gatttaggaa cattcggtag aggacaaatg gttcctgaat ttgaagaagc
    29221 tgtgttctct atggctaaag gtgaagtaag tgaaccagtt aaaactcaat ttggatacca
    29281 tataataaaa ttagaagacc ttcaagaaag tacagagtct acatttgatg aagttaaggc
    29341 tgaagttgaa aaaagtttat tatatcaaaa acaaaatgaa gtttatggaa ataagataaa
    29401 tgctcttaat gctaagtacg gaaaccttgt aaaatacaac gattaatcat aaggtcatat
    29461 ataaaaaagc tgtcttttca caatatttat tagaaaagac agctttttat attaaagttt
    29521 aaatattcag tttcatatta tcattttttt attgtaaaga actcagctta aaagtttaaa
    29581 taagattttt aattatcatt agctaaattt ttatatccac gtattatctc ataacagtaa
    29641 cctattacat ctcttctttt tattatccca ataaatgtgt cttggtcatc tataacagga
    29701 atgaaatttt gatttaaaga ttttataact aaatcttcaa tatctgcgtt gatggaaaca
    29761 ggagaattat ccatttttct atttatatct gtcactggaa catcttccaa tccctttaag
    29821 tccagattta aatcattttt taatgtccat aaaaaatcac cttctgttat agttccaaca
    29881 tatttaccat ccttacttat tattggaatt gcagagtatt tgtgatattc cattttttct
    29941 agggcttgcc ttatagtgta gtcttcatat atatatgcta cttcactttt tggtgttaga
    30001 aagaataata tgttcattac actacccacc gttactgaaa acttataaat attactcaat
    30061 atttataatg ttactttttt gcagtaactt tctcctttct tattttctaa gtattcttaa
    30121 tactatacgc tgtaacaagc gtttttcctt tgctcatttt aatcttatta tgctttatta
    30181 atatttttat atggtctata agtatcactt attctctttt tagaaaattt actaaaaatt
    30241 aattgactta aacttagcca taataatttt actctacact attaatttta acatatttat
    30301 ctcattatta atgattttat tttaataatt ttaatttatt ttgctattaa ttttatttac
    30361 aaaaactgaa aaaaccgcta aatgattagc ggcttatctc tcatattact agaacactaa
    30421 tatatatgaa tttttaatta taatctaact acgttagcag cttgaggacc tttagctcca
    30481 tctactactt cgaactcaac gctttgtcct tcttctaatg ttttgtatcc atctccagtt
    30541 atagctgaga aatgtacgaa aacatctcct tcaccttcta cagatatgaa tccaaatcct
    30601 ttttcgttgt taaaccattt aactacacca gttttcatta ataaatcctc ctaaaaaaac
    30661 acaaatattt agctactctt ttctgtaacc ttattactac tctatcatat atagctatgt
    30721 ttgtcaatta ttattatttt tatacattaa taatcaattt ttttacttta taattttaaa
    30781 tgattattat cttttacact ttatttttct ttataatttt ttaataattt atttttatta
    30841 tatggaatct tatggactta tcactccagc ctaaatccca tggcaccaac attctatcag
    30901 tattatggca agttaccaaa ggatatcctc ttgagtctaa tcctgtcact gtcgaaacat
    30961 gtgttattct gcctttcttc tcataaccaa caaaatcccc tggacgtaaa ttataagctt
    31021 ctttgtatac ttcttcatag gaacctttag caattaatga acctcttcca ctatacagtg
    31081 cataattttt aaaagcttgt gcatttaccc atgcttttgt acctgctctc tcgctataat
    31141 tccaaattga gttctttttg aaccttccac tttcaaacat tatctgtgat gcaaagtttg
    31201 cacaatctcc accttctgga ttataatccc tatagtttgg attaaatttc ataccatgtt
    31261 cttcatcagc tgcggctcca cagtatttat gtgcataatc tatagctttt ttttgttcat
    31321 ctgtaagctg taactctaca ccatcttgtt gaccaatata atttcttata tcatcagatt
    31381 ttatattttc taaatttaaa gagtctgcaa aagggtctgt ataccactct ttagttatga
    31441 catattgatt atctataatt tttacattta gataatgata tgtacctatt ctaaaggcat
    31501 tttctttgtc cttttgattt tcatatgaat acttatattc agtggatact gaacagatta
    31561 taccatagag gtctttttct ttttccttta tttttttaat cttaaccctt gtctttatgt
    31621 ctttaaattt tacaccttgt ttactagacc agttttctaa atatttcatc ttttttactt
    31681 cattttcata agcccacaga ccaaattttt tatccgtttc ataaagacct tttaaaatat
    31741 tttcattttt ctctaatatt gccttatttc tgtagtcaaa taagttttca agcaatagtt
    31801 tatattggtc ttttacatca tcaccttcaa catttgcaga ttccatgact ttttcttcca
    31861 tatttttcat acttaaatca ttgattaaaa atacacctgc tgtagtagct aaagacaaaa
    31921 atacaaatgc cattatacct ttgatgtact tattcttatt tttcagtatt ttcaaagcta
    31981 cacctcccaa atagtacacc ttacaaatca aattacaaag aatattctgt cacatatagt
    32041 aattttcata tttaataatt ctctatttta ttatgtccaa tattaaaaat taattgtatc
    32101 aatacactgt tttttttaca attttttatt ttataatcta cttttttctt ttttttatag
    32161 taatatatat gtatataaat attttggtat cattataatt aatacatact aatggagggt
    32221 tttttatgca aaaaaaagtc gcagcaatta atgacttatc tggaatagga aaatgctcat
    32281 tatcggttgc tatacctata ctttcagcat taaaggttca atgttgtcca tttccaacgg
    32341 ccatactttc aagtcaaact ggttatcctg aatttacttt cttagacttt actgatgaaa
    32401 tggtaaaata ttcaaatgtt tggaaaaatt taaaagtcaa ttttgatagt atatatagtg
    32461 gttttttggg ttcaaagcat caaattgaga tagtggctaa ttttataaac gattatccca
    32521 atgcttttat cgtagttgac cctgtgatgg gtgataatgg agttatgtat ccaatattca
    32581 cagaagaaat gagacaggaa attaaagaat tagttaaaca ttcagattta actactccta
    32641 atttaacaga agcttgtttc ttaactggaa atgattatac caaaagcgat tataatagag
    32701 atgagcttat atatattgca aaatctgtat ctgatttggg acctagcaaa gtcgttatta
    32761 ctggtatatt agaagatgat aatatattaa atttggctta caatagagat aatgaccatg
    32821 tattctttac atcagtcaaa tataataatt gttcttacag tggaactgga gatatattca
    32881 catctatact ttgtggtatg ttagtaaata aacatgattt gggagtagcg gttaatactg
    32941 caacagattt tatatataaa actataaatt acacatctca atttgatact gatagaaatg
    33001 atggagttat gtttgaaaac tttttatcag atttaaccaa tatataaaat caaaaaaact
    33061 atccatttta taaataccta taaatcataa aatttaggta tttacaaaat ggatattatt
    33121 tactaaacta ttggtatttc aattgttacc atagcaccac cagttttcac agaattttca
    33181 atacataaag tcccattatg tttttgtaca atattattta caatatagag tcccattcca
    33241 taatgagatt tagaatttct actcaaatct cctgtataaa actgttctgt agcttttgac
    33301 aaatctgctt tagaaaaacc acttccacaa tctgtaacta caaattttaa gtatttatta
    33361 tgtactgata cacttatgta tagtttactc tggcttggtg aataatctat agcatttgaa
    33421 attatattca taatagctct gaataacagt tctctatcta tagttatatt tttaggcaaa
    33481 ttatcttgtt tataaaactc cacatctaag tttttagtac tagctaatgc ttctatttgc
    33541 actaaaacat cttttataaa ctcactcata ctgattgctt ctttatttaa tatatagcca
    33601 ttctctgttt ttgatatatc tattaaagta ttaatatatt tttctatttg agtgacaccc
    33661 tttgagatat attccatgta ttctaataac tcaggatttt catttatttc aattaataag
    33721 tcagtatttc catgtataat tgttagtggt gtttttatat catgtgccag tgcagatatc
    33781 tgttcctttc tattttcttc tagcatccat tgtttttcta aagaatcttt taacgccaac
    33841 ttcattttat ccatagaaaa aaggacatta ttaatttcat aaattttact agattctaca
    33901 acaaaatcta aatcctgttg ttctattttt tctgtagtat tttttaaaag ctccatttca
    33961 atattaaatt tcttgccaaa tacttttgat aatataacaa tttcaataaa aaatattata
    34021 ctaaaaataa tcatacccaa tgtctctggt tttggtaaat atgctcttaa aattggagaa
    34081 ctatactctg atactatttt gtattttatt ataaaaactt catctttctt aaaaaacttt
    34141 atataacttt ctgaatatgc atgcctttct tcaatatctc tcattaaatt ccatacttct
    34201 tttgattctt ttttattaaa ggtccctgaa attaaattcc catccaaagt ataaacccca
    34261 tactcatata tacttggaat tatatcttca gttacttttt cacttgaaat aatctgttct
    34321 ttatatttat taaattgttt ttctgcataa ttagctggta aaattacacc tgatgataat
    34381 aatacagaaa atgataacat taaaaggagt acaattgaaa ttgtcataat aaagaataaa
    34441 gataaatatt ttataaaaat agttcttaac ttttcaactt ttttgttgtt agatttttta
    34501 cctccaagca tttgtaccct gtcctccaat agtttaatta attcataatt aatacccaac
    34561 cagtttttta tttgattatt ttatatcttt ttattgctaa gttatatttt aacataataa
    34621 tataaataaa cagtcaattt ttactctatt cttctgattt tttaccttcc catttagaaa
    34681 accaaataca taaaattaca aatgctaaaa ttgttacaaa accacaaatt aaacctgttg
    34741 attgatatgc ttttattgat tcaaccttta tatattcaac cgttttagaa cttgaaaaag
    34801 acgaccaaat agttataaat ctaacacccc atgcacaagg aaaatactgc caaataccag
    34861 aacccaatcc agttaataat aatgctgaaa gtaacatttc aactatacct actccaattg
    34921 atgttccttt tccgaacctt aaacttaaga ataaatgtaa tatgtattca aataaattac
    34981 acccaattaa aattagaatt gaaatcatat aaaagcttga tgtaaagtaa gccttagata
    35041 taccaaattt aaaacctaat acagacacta atgttgctac aaaaccaaga catactaaga
    35101 ttatatattt acttataaga gtaagatatt ttggattaga tgttgttaac atatgtttat
    35161 aattccctgc ataatattct tgttcaacaa acattgaaca cacaacactt gacaataaag
    35221 gaaaagctat tgctataact tgtaaatatg ctactatctt tagtatatta tcagctcctg
    35281 aaaccttata ataccataaa aacaatccca tccccattaa agcaatgcaa atgtgcatta
    35341 gtattataaa atttctcttt aattttatta aatcagaaca aaatattctt attaactgtc
    35401 tcatattact tcacctctct attattgaac caaacccttg tagctaaagc aaataataca
    35461 aataaaacaa tagatattaa tactcctggc aaaataacag cattatttaa aaattcactt
    35521 ccctctggta caggaagacc atttggcaga atatgcaata caacagccat taatcttgaa
    35581 ggaatcgaat atggaaacat ataccacatt tctgtagttg agaaaacagc aactccaaca
    35641 atagtaaaga acatatttgt tagaactgta acaaacatac caaattttga agctaaaaac
    35701 atacaaagag gaatctgcca cataaatagt aaaataatta atatacttgc aatgatattt
    35761 tgacctattg aaatagtttc tttatagatt atcccaacaa aaactacacc tattgcagaa
    35821 ataattgatg ctataaaaca acaaataata cagtaaatca tttttccagt ccaaacgtct
    35881 ttcatttcaa ttggcaatgg taaaatacca cgatatttac ttttttcatc ttttaatact
    35941 attaaagaag atattaatgt taatgctcct ggaagaaatg tcgtatacca ccagttgaaa
    36001 gcagcatttt gccctccacc tagtccacac aaaagtatac aaaacactgg aactatccat
    36061 atcaacttca ttccaaaagt tcctttcatc ttttgaaatt ccactctaat aaatctttcc
    36121 atattactgc cctctctttc tattttcagc tacaactttc ataaaaagtt cttctaagtt
    36181 ttgttctttt gatacttctc cttgataacc cattactcca ttagaaatta ttcctatttc
    36241 atctacaact tgttcaactt cagacaagat atggcttgat aaaataactg taattccttg
    36301 ttttggaaaa gaacgaatca attctctaag ttcttcaata ccaatagggt caagaccatt
    36361 tgtaggctca tctaagatta aaagttttgg gtgatttaat aatgcaatag caataccaag
    36421 gcgttgcttc atgcctagag agaattgacc tgaacgcttt ttaaaggtat ctcttaaatc
    36481 tacagtctct aaaacttctt caatgcgaga gtcaggaaga ccaagtaaag tagtatggac
    36541 ttttaaattt tctcgtgctg ttaaattctc atatatagca ggagactcaa taagagaacc
    36601 aatatttgat aaatcctttc tagtccatct atgtccctca aacattattt ttcctgaagt
    36661 tggatttaaa atcccagtta tcatttttaa taaagtagat ttcccagctc catttggtcc
    36721 taataatcca tatatagaat tagatttaat tgctagtgaa atgttatcaa ctgccatctg
    36781 ctccttaaat tttttagaaa ctccttttac ctgcaaaata taattactca taattttcat
    36841 cctttctttt gtcaaactta tttacaagaa tcattctaaa tcataaatat aaggatttta
    36901 taagaattaa aaaacaaaaa aagatgtgtt aaaaacacat ctttttttat cttaattcta
    36961 ttaattttcc attgtagtat atctctactt cttcaatcca aatgctatta tcttcttctt
    37021 ggatgacatt tttaataata ttatttatag tatatattat attttgttca ttcaaataat
    37081 catctttcca agaaactcta ctttttttat ctggttctat caagtttatt ttaacaagat
    37141 tatctttttc cttaacttct acttccatgt ctaaaccatt aaaatactca tttgataatg
    37201 tatctaagat taatcgcagt ttatccttaa gtgaactttc ttcatcaatc tgtaagtact
    37261 ttactatttt ctcatccttt gaaattatct ctataggtat tttagtagtt tttttagaat
    37321 taatcatttt actagttgtt tcttcttttg catcttcatc cttctttaca actgctgatt
    37381 ctttagaatc aactagctca actgcactga tgctataatc catacatgcc gtactcaata
    37441 aagtagtagc aattattaaa aaacttactg ctattttatt cataagtatc cctctcctaa
    37501 ttctctttcg atacttatta taccatagta tagattatat ttttatactt ttaaatcaat
    37561 ttataaatta ttatagtaaa ttatttacaa ttctaagcta tttgaattta tttttatagt
    37621 atattctttc tctaaattcg acagattttt attcaaaagc ccttttattt ccctcgtatt
    37681 tctatacttg ttgctatgtt cttcattatg ttcataatca tatgaatcat tgtcatattc
    37741 ttcatcatta ttaaattctt caattgcttc ttttgacttt atatcacaat taaatttata
    37801 cttatttact ggtatatcaa gtcttacctt agaatttgga acttctatgt ccaggaactt
    37861 agcaattggc atatcagagt acaagtaaaa ttcactttca taatttgaat ttctacctat
    37921 tttctctttt atatttacat tttcaggtat atactcttct atattattga taaatacatc
    37981 tccattctct gaagatatat ccaatgactc tgattctatg tttacatttt taacgcctaa
    38041 aattgacttt gttgatagat gaagattgct attagatatt aagtttaagt tttctaatct
    38101 atttacttta ttttctgtta tagctctgct aaaacctcca gaagaagttt tatatgttat
    38161 attatttgaa tctacatcat cagatataaa taagtacgaa cttatacttg atgcatttat
    38221 atctacatta tttggtacat atattctaat ttctctataa tcacgtgaaa acatactatt
    38281 tatagatgta tttaataagt ggtcgaaact tctaatcttt ttaattttat tttcagattt
    38341 tctttcgcct tttacaacta aagtcttatc ttgtagggtt acactgtatt tgtaaaattc
    38401 attattccct cttgttgtca cacgcacatc ttcatttgaa ctttttctta tcataacatt
    38461 tatattgtca acagctatat ctaacttgtc aatatttact ttttcttgat aaagtttgtt
    38521 ttctttgttt aattcagctt ccttttctaa accaaagttt attaggcttg gcataactaa
    38581 aatccctgac catgttgtcc ctattatacc tattaccaat aaaactgcag caaatatagc
    38641 aagtttttta ttcatgttta tcttctcctt tcttattttc tatatcttca aggtccttat
    38701 atatcgcctc aaaatttata ctatcatcat tatattcatc agtttctttt atgctttctt
    38761 cttctctatt gtagtaatca ttattatatg aattttcatt aatgtcttta ttcaaatctt
    38821 catcatttaa agtagctttt tttctttttt ccatcttttc atttgccttt atataaatat
    38881 tttttctctt tatccaatgt atataattat ttagtaattg tttacctagt tttatggcaa
    38941 ataataaaat ttgccatgca agtatctcaa gccctacaaa tgctatggtt gcgaaaatac
    39001 aaaacatcat aacatctgga accattgcta taaatttaat cacaaatgga attaatataa
    39061 caaaagcaat taatgagcat actaatgcaa tagtagcaga tacaatagca catacaaacg
    39121 caaatgctgg aacaattaga aataaagata acactactaa taaccccttt ataacttgtc
    39181 tggataatcc tcctacacct tcttctatac ttggtgtaag tttatcattt atattttctt
    39241 ttgatttatt gtacttttcc ttagcttcat ctttcaagat agaataatcc ttttttacat
    39301 ttgatttaaa tctactaaat ttaccattta atatgtctgt attcattatt tttccatcta
    39361 tattttcttt tgatttacta tacttttctt ttgcttcatc ttttaagata gagtaacctt
    39421 ttttcatatc tgatttaaat ttactaaact tatcattcaa aacatctgta tttattattt
    39481 tttcctcttc aatatttttt tctttagttt gtaagataag ttcttttgct atagattttg
    39541 gtgagccaag tgatgctatt atctccatat cactctttcc ctctataaga ccatctacga
    39601 aatactcttc ataatctctc aatatatcat taacttcgct ctcagaaaaa tcttttttta
    39661 gataatcctt taaaatttca agaaactcag ttttattcaa gttcattacc tccctcatct
    39721 tcacttatta aaatctcaac agcctttaca aattctctcc actcttccat cagattggat
    39781 aaattctctt ttcctagtga agttattcta tagtattttc tagcaggacc ttcattagat
    39841 tctagtatat atgtttcgaa atacaaatct tttgtaagtc ttcttagaat aggatatatt
    39901 gttccttcat ttacatctat tactttagag atgttatgta ctatctcata tccatacata
    39961 tctttcttag atatgagagc aagtacacaa atttctaaaa caccctttct aaattgtgtg
    40021 ttcatatact ccatcctttc tttaaataca cagtattgtg ttttacaagg tactatgtta
    40081 aaacttctta tatcctcata ataacacagt actatgttct gcacaatagt tatttttaaa
    40141 tattcttgtt gattaaatcc ttctataaat gtataatact ctaatcagat atattttatg
    40201 aaagtggtga taaattggct aaaatgaaag atgataaaac aatattaatc ctaactgctc
    40261 aatttggtgc tggacatata agtgctgcaa aagcagtcaa agaatgtatt attgaaaaat
    40321 atagtaacta taatgttgtt atacaaaact ttataaatgc aagtattccc atgatgaata
    40381 agcctatggt aaaactttat gaaaacaata caaaatatac tcctggatta tataattact
    40441 attattactt taagaaatcg tttgattcaa gacatgattt atctcataaa ttatatacac
    40501 ctaaactttc tgagtatatt gctgatataa atccagattt gattatctct acatttccac
    40561 tagctgctgc ttgtgtaaat aactttaaga taaaaaatcc tgatataaat atacctacac
    40621 ttacagttat aacagatgtt gtagatagta tggaatgggt ttttgaaaat acagatttgt
    40681 attttgttcc ttctcctgaa ataaaaaata gattttttca gaaaggaata aatccagact
    40741 ccataaaggt tactggagtt cctgttgata agagatttca aattgaaagt aaagaactat
    40801 gttgtgataa atatagacta ttacttctag gtggaggaag aggtctattt gatatagatg
    40861 aggattttat gcattggata gatgaattta ttgaagaaca tagtaattct atagaaatta
    40921 caatagttac tggtaaaaac aaaaaattat atgacaatct aactcataaa aaacctctaa
    40981 aaaatattaa agtacttgga tttgtaaacg acatgtataa tctaataaga gaatgtgacc
    41041 taatgctaac taagcctgga ggagcaacta tatttgaagc tattcaatca caaactccag
    41101 tactcgtaaa aatgccaaaa gttggacaag aaattgaaaa cgctaaattt ataatagata
    41161 agggtcttgg catgatttat agtgatgacc tagaccttaa aaacatattt tataaattag
    41221 tatcaaatga atttgattct ataataaact ttatgaaaaa aaatttaaaa gaatttaaaa
    41281 cagtcattca tccagagaaa attgctgatt atatatcaga attaatagat aatcattaca
    41341 gttaaattgt actattaaaa aatttcaaac ataaaattaa aggcaatcaa gtatgctttt
    41401 acacttgaga atttactcat agtgtttaat aatacttgat tgcctttatc atatcaaaat
    41461 caaattgtta tattagtata tatttttctt gtactgcata tacagttgtt gtatttcttc
    41521 catacttctc tttaattcta tttgtaaatc tgaagcagtc tggtaatcct tattttctat
    41581 agcttctctc actctagtga atagtgattc tctagttaaa gtatccttca taatattgaa
    41641 ctttaaatcc gatattgagt tccaaactac ctcatcaagc gcatccatat tttcttttgt
    41701 gtgtatcttg acaatacttc ttattttttg aatcccagcc tctattattc tagtttttaa
    41761 tttcttttgc cacttatcta tagctccaat cttaaatgat tctattatac tatcagtaaa
    41821 tacatcacct tgttttaaag attttaattt tgaagcatat atttctaagt ttttcatatt
    41881 ttcataaact gtagccggtg gtattccaaa tcttgcattt ctttcttcca aactataatg
    41941 ttcaaataca tcattttcat ctctatatgc tctatctttt tctaaataga aactttcttc
    42001 acctacattt ttagataact ctttttcaag ttcttttgta ctaagaccac tcttagctgc
    42061 tgcttttata ccatccaaca ttgtttgata acatcctgct attactaaat acgtgttaga
    42121 tagagggctt ggtgacctta actcaaatct tacagtcttt ggatttttca tatctcttat
    42181 taatccaaca agcactgacc tatttcttga tggaatctca taactatgac ctaaagatgt
    42241 aactatgcat acaggagctt caaatccagg aactaatcta ttaaatccat cattagaagc
    42301 tgttacaatt gggtttaata cttcataatt gtaaagaagt cccataagag ccccatatcc
    42361 tagttcactt agataatctt cttttaaatc ttttggcgca aatagatttt ttatacttcc
    42421 atcctttaac ttcgcactta ctcctacatg tgtatgtcca ccacttcctg ctactccatg
    42481 aattggtttt gctttaaatg taacttctag tccatgtgat gtaaatacat cctctataac
    42541 atctcttact aataattcat tgtctgctgc ttgtaacggt gtagaaaact tccaagaaac
    42601 ctctaattgc tccatagcat ggtttgttct tccatctata ctaatagaac tttgtattcc
    42661 tccgacctct ttgtgagcca tttcagggtt tacacctagc ttttgaagta taattaaact
    42721 tttctctaaa caagttctta taataccatg agttcttttc cagtattgct cttttaggct
    42781 ttgtgataca tataatttct ctaagtcagc tttatcctca ggagtattaa cccagaactc
    42841 aagttctgta gctgctgtta acattatttc ctctatatca tctactgaat ctattcctat
    42901 gttatttatt acatgtggat attctctaaa tatttcatac attgactttt taaagtactt
    42961 atctgctttt tgaagtactc ctctagaaca tactttttta ttatcatgta ttaaaaatgc
    43021 aggtatcttt aatgttccaa caggtagacc tacttcttcg tctatatatt ccatattgta
    43081 atctacatac caatgacaac ttttatctgg cattaaatct actttcgcat tatttaatgt
    43141 agctatatta taaagctcaa cacttgaacc atcagtctgt atagctgatt ccaaaaattt
    43201 atctatatcc tccaaaaata attctacagg aatcttttca tctgttgcat ttcctcctaa
    43261 atcaaccccc attaaggaaa caaatcttat atttttattg ctttttagga tttctcttaa
    43321 ttcttcatta gtgtgtttat ctttctctat tacgtataat agactatcca tttttccact
    43381 ctcccataat ttttatgtat attttatttt gttaaataca agataaattt cattttcctt
    43441 acatttatga atttttcttg caaattattc gtgttttatt cgtgttttta tttatattat
    43501 tatatatcaa gtataaaaag ttcgcaatat tttttattgg aaaaaatatt atacatacaa
    43561 tagtttaaca tttttacaaa tatggggtat actaaaataa aagtattttt atttgaaaat
    43621 ttaattttat ttataatata atctatagta aaagaaataa taaaaaaatt taggagataa
    43681 actttatgga atacataatt ttcgatttgg aatttaacca aggatttgat aaaaaactca
    43741 ataaaactgt atccaatgaa aagtgtcctt ttgaaattat acaaatagga gcaattaaat
    43801 tggattctaa attcaatata atagatacgt ttaatagcta tgtaaaacct acaatttata
    43861 aagacataca tccctttatt agtcgtatga ctaatattaa aagttctgat tttaatgatt
    43921 cgcctacttt ccctgaggtc tacaacaatt ttataaaatt tatatcatca caagacccta
    43981 tattatgtgt ttggggagct ggagatttga aggaattata caggaatatc aactatcaca
    44041 agctaccatc aaattcctta cctaaatctt atattaatat acaacaacat gcatctaaat
    44101 atttcaataa tccagcagga aaaagcattg gcctacaaaa tgctatttct atattggaac
    44161 ttgatgaaaa aatgtcttat cacaatgctt taaatgatgc atattatact gctaaagttt
    44221 ttattaagat atacaatcca agtatagtcc cagatatata tctttatacg agtataaaac
    44281 ctaaaactat aagatattct aacaaaaaaa gagttgatta tgataagtta tttgatgaat
    44341 ttaggaaaat tttaaatcgt gaattaacta aagacgagaa aaaaatcatt aacttagctt
    44401 ataatatgtg gaaaacaaat caatttacat tagaaaatgt taagcaaaga aaaaacaaat
    44461 agagtttatt tagataaaaa ataggcatgt agattaaaaa actagttaac tttaaattta
    44521 tatctacagc ccaattttta tcataattaa tttttatttt atctctaatt caactggaca
    44581 atggtctgaa cctaatattt cagtgtgtat atccgcactt actaatctat cttctaattt
    44641 tttggatgca caaaaataat ctattctcca ccctgcatta ttttttcttg cattaaatct
    44701 atacgaccac caactataaa caccttcttt atcaggatta aaatatctat atgtgtctat
    44761 aaacccactg tctaataatt tagaaaactt ctctctttct tctttagtaa aacctgcatt
    44821 tttcatatta tttttaggat tttttaaatc tatttcttta tgtgcaacgt tcatatctcc
    44881 acacacaatt acaggcttat gattatctag tttggttaaa taatctataa agtcgtcttc
    44941 ccatctagtt ctatattcta gtctctttaa ttcagattga gaatttggcg tatatactgt
    45001 aacaaagtaa aaatcttcaa actctagagt tatcactcta ccctctttgt catgttcttc
    45061 tatatttatt ccatacatta cttttaaagg ctcttttttt gtaaatatag cagtacctga
    45121 ataacccttt ctctcagcat aattccaata ttgaaaatat cctggtaaat ctaactctat
    45181 ttgcccttct tgcaatttag tttcttgtaa acaaaatata tctgcatcta cttctttgaa
    45241 aaagtctaaa aatcctttcc caacacaagc tcttattcca ttaacattcc atgatataaa
    45301 tttcatactt atactcctca tctaaacatt gacacactcc ccatagctaa agatgggggc
    45361 ttttcaacaa ttttattgta aattcttaat ttacttttat tttaacaatg ctatactata
    45421 atttcatcta aaattactat ttacttaata cctaaaaata tatgttttaa tcaattttta
    45481 acttttttgt taaatcttca gggctcattg aagaaacata catatttgtt ccaagttcaa
    45541 atcctccaaa attatatttt cttgggatta tgtgcatatg aacattaaaa tacgattttg
    45601 tttcaatctt tgttggatga gtgtgaatac ataaattaaa tggcatatat ccattgatat
    45661 tgtataactt cttaaacaac ttttcaaata ttgtagaaag ctcctgtata ttattatcat
    45721 ttaactcacc aaactctatt ttatctttaa atattattct tacttctcca ctatacttgg
    45781 ttgcatatgg tataagtacc aaaaaagctt ctccattata aacaactctt ctatctaaac
    45841 ttatttcatt ttctattaaa tcatcataca aagagctttt attgctgtca taatactcct
    45901 ttgaaaccaa cagttcattc gtaatttcag gtggaataaa agacatagac aatatttgag
    45961 catgtggatg catcaaagat gctcctgcct ttctcaagaa gtttttgaag atactaacat
    46021 actctacttt atcatctttc gacaaatctc taaatctatt tctatacata aaaaaaacat
    46081 cttcaaattc tttttgactc atgttataaa aactacgatt atgtttatcg ctctctatca
    46141 ttacttcatg aacaccatat acatctcttg ccatatcatc aattatagga aatttattgt
    46201 agacagattt tacaagccat ccttcttcac tatctatttc aaataatgca tcagttgcat
    46261 gagcttcatt tcctttgcaa aatgggcatt cttcatcata ttcattagtt tcttcatctt
    46321 catttgggat atctgctgta tctaaaggtc tttttaacct atctgtagca aatataacaa
    46381 catcattggt aattggatct attcttaatt ctttcataat taacacc
//
LOCUS       DAEQCW010000018        44936 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.018, whole genome shotgun sequence.
ACCESSION   DAEQCW010000018 DAEQCW010000000
VERSION     DAEQCW010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 44936)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44936)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44936
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.018"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(51..1454)
                     /locus_tag="KRO40_001069"
     CDS             complement(51..1454)
                     /locus_tag="KRO40_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091898.1"
                     /translation="MHKPSYKTVFHSYIIFFMIFICLILTVIGIFLSLITIQKPNGEF
                     IRSDWPKKFTENFNEQIVFIDNKPQVKQSGLEKLRENQLWLQILDSSGNRVYGFLEPK
                     EHKDYYSNSELLALANQNNSSNGTVYFNTIKNNKNDYIYIIYFPLNISKVNMFFDGGK
                     FIGGKSIVFSIIGIIFLIILVSGIAYGYWVTKCISNITSAVSDISKRSYLPVNIKGVF
                     ADIYNSLNILNEEIHKSDEIQNKTDIMREEWISNITHDLKTPLSPIKGYAELLTDSST
                     NYSPEKVYKYASIMLKNIEYTNTLINDLKLTYQLKNGIIPLNKNNYDLVRFLKELSID
                     ILNYPEYESKIVEFKSNIDNINFDFDCTLLKRAFSNLIVNAFTYGYKNTKVCVHITLN
                     ERIEIIISDNGKGMSREEASNLFNRYYRGSNTKQKIEGTGLGLAITKQIIEVHGGNIS
                     VESIPGLGSSFYITFPI"
     gene            1952..2812
                     /locus_tag="KRO40_001070"
     CDS             1952..2812
                     /locus_tag="KRO40_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2091899.1"
                     /translation="MKKQKSPILLEMLGLFFGCISMSIGINMFLKPHTIAPGGLSGLS
                     LVLNKVTGLPVSAIMLIIGVPLVILAFRIMGTKNSLKTLFGTVVFSAIVQLTDPLSKL
                     RFTNDLLLSSIAGGILVGIGLGIMFKSDASTGGTDLIALILSKKFPGIKATKFMSCLD
                     GMVVISSGIVNRSLETALYSGIALCVLIKIADMIMEGFDHSKAFFIISDEPESLRQAI
                     TEELDRGLTILDGKGGYTRENKEVLLVVVSKKQELYLKRLVKRTDPTAFVIVTDVHEV
                     LGEGFKNLEN"
     gene            complement(3051..3608)
                     /locus_tag="KRO40_001071"
     CDS             complement(3051..3608)
                     /locus_tag="KRO40_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2091900.1"
                     /translation="MSDSEYPQMKTLETRSCILRPASLDDVEDFFDCYKNKIVVKHLP
                     FSEHKSLEDTRKFIKSFFLNPYKKGKIGHFAIVYKRDNKVIGNMGFNNINPKALEAEI
                     GICINPSYWGHDFATEITKRVIQYGFRELNLNKIIAITYEENQNSKKSLDLLGFKCTG
                     KYIKKIHTGNTVKNVPCYQYELKKQ"
     gene            complement(3798..4685)
                     /locus_tag="KRO40_001072"
     CDS             complement(3798..4685)
                     /locus_tag="KRO40_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2091901.1"
                     /translation="MNIKLELYKVFNAVVNNKSFSLAAKELFMSQPAVSQSIKQLEEQ
                     LDTLLFYRNNKGVKLTPEGKILSEHVTTALKLISSGEDRINKFKKLEYGSLKIGVGDT
                     AARFFLLKYLEIFHKKYPHIHVSTINRTSRELISLLKDGNIDIAIINMPIEDDTLNIV
                     ECIEIHDIFVCANDYIEYKGRKISLEELNTLPLIMLENKANSRLYVNEYFLSKGIKLN
                     PDIELGSHELLLEFAYINLGVSCVIEEFSIDYLENEKLFKLDIKEPIPKRNIGYCHLK
                     DISLSLATKEFLSMISNNI"
     gene            4804..6003
                     /locus_tag="KRO40_001073"
     CDS             4804..6003
                     /locus_tag="KRO40_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003493023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coenzyme F420-0:L-glutamate ligase"
                     /protein_id="HBH2091902.1"
                     /translation="MDRLVGTVSRGVRAPIIRQGDDLVKIVVDSVLNASKSENFEVRD
                     KDVIAVTEAVVARAQGNYAHVDNIAKDVKDKFGDDTVGVIFPILSRNRFAICLKGIAK
                     GCRKVVLMLSYPSDEVGNHLISIDELDDKGINPWSDVLTEEKYRELFGYNKHTFTGVD
                     YVDYYKNLIKDCGAEVEIVFANNPKTILNYTTSILTCDIHTRQRTKRILRQNGAKKVY
                     SLDDIMTASVDGSGYNDQYGLLGSNKATEETVKLFPINCDEVVNKIQGNIKEITGKDV
                     EVMVYGDGAFKDPVGKIWELADPVVSPAYTKGLEGTPNEVKLKYLADNDFADLSGDEL
                     KEAISKYIVEKDNKSDDLTGNMVSQGTTPRRLTDLIGSLADLTSGSGDKGTPIIYIQG
                     YFDNYTK"
     gene            complement(6197..8752)
                     /locus_tag="KRO40_001074"
     CDS             complement(6197..8752)
                     /locus_tag="KRO40_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2091903.1"
                     /translation="MMSLVKFSIQYIKHYKKQSISIVLSIVLSVALLTGIGSLVHSAD
                     KSRIEKIREDSGDYHYFYKVDKEQLNKIKENKKSKEYTVDRLGITKPKNQIDEPFIIE
                     FLNADSSYLDMTGRKLLKGTLPSKDGEIVLDTYSLNNLNVNKEIGTEINLDGKIYKLC
                     GILSSLSNPETALEGFVNDYFQPKEKDSYIVYVKYDENKNIKKQNYKFMKKFNISKEK
                     TYINWPLSVEFGVKPPKNIEKYNIFEFLKNLELNTNAIILLVGVFGAAAVYSIFHVSI
                     LQRISQYGVLEVLGANNKQLLFLLFLELFLLFIVGFPIGCFLGIEVASTIYEQFPHIF
                     LSSDIVPGAFFISEKSIYLGFLFILLLLILIAVRVVHQLNKYSSIESMKNFKITNKKK
                     RILESVKHSNMTKVLSHKYMTQKKGMFIGILFSLSLGGIIFLCSSYSIQLTKNNNELT
                     MKADDGLNSDYQITMQTTDFDVGIPKDKISRLNNVEGISKVYPVRYLFGAMQIKEEQL
                     FWKNFFKPLEKDYRIKTFFDGICTKQNEGGYLLKTNIYGYNNGMLEGLNSYIIDGEIN
                     THDMVKNNKVIVRLPMDGTGMYDAVDINPGDTIKVKVPKTMKPTDEIVKFKEENKNDY
                     TTKEFVVAATVKRVMANNIYFIGDYGMDIVMTNGQMKNNFDIENYNSVSIKKTEDSNS
                     EELSENIKSVVSDVKRCIVTDYTIAIEKNNTYLNQKLLFIYGIVFVLLAISLFHIINT
                     VSYLIFSRRHEFGILRAMGITDNKFLLMMIREGFLYGFYASIIMVIGSVIGQFMIYFM
                     VKRVYLYINPILKINTPLYIGMIILNITISIVAVIIPVRQILKSDIISEINKN"
     gene            complement(8749..9435)
                     /locus_tag="KRO40_001075"
     CDS             complement(8749..9435)
                     /locus_tag="KRO40_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091904.1"
                     /translation="MSILVTNNLVKHYGKGETKVKALNGVSIEIERDTFTAIVGTSGS
                     GKSTLLNIIGGLDNPTSGDVIIKGKNISKIGKKDLTVFRRRNIGFIFQNYSLMPVLNT
                     YDNIALPVTLDKGNHIDHEYIEMLMKTLGIWDKRLKFPSELSGGQQQRVAIARALANK
                     PALILADEPTGNLDSKTTMEVVCLLKESSAKFHQTILMVTHNENIAQVCDSIIHIEDG
                     VVVNTGGEVL"
     gene            complement(9512..10420)
                     /locus_tag="KRO40_001076"
     CDS             complement(9512..10420)
                     /locus_tag="KRO40_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091905.1"
                     /translation="MFILAFIICTVVIFIVSTKINRKRYDELNLMLNQILEGKEVTYP
                     DTKDTRASKISHQVKKIKDMIEIEVEQSKSEKEAIKGLISNMSHQLKTPLSNITIYCE
                     LLENINISTLQKKEFLQKMKNETFKIDWLLQSLFKMTKLEDGVIEFEVEELLIKDTLI
                     QSISTIFNKAEAKNIRINLEPFSDIKLVHNKKWTIEAIVNVLENAIKYSPSDSTITIS
                     VIKMELYTKITIKDEGIGIDSRELNDIFKRFYRSKNVENQNGTGIGLYLTRLILEKEN
                     GNIIVESKLGSGCCFSIFLQNCKSLN"
     gene            complement(10422..11093)
                     /locus_tag="KRO40_001077"
     CDS             complement(10422..11093)
                     /locus_tag="KRO40_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091906.1"
                     /translation="MNLLIIEDDINLNEGLFYAFENDGFNVFKAYTKQEGLNIFNSKN
                     IDFIILDCNLPDGYGFDVCQIIREKSDIPIIMLTARDSEIDEVKGLEIGLDDYITKPF
                     SLSVLKARVKVAIRKKSNNKVIYSNGIKLDQKLLKVYKNKECLELSSVEYKLLSYLIE
                     NKGQILLKEQILHHIWDSEENYVDDNIVSVNIRRLRVKVEDDPSNPKYIKTAYGMGYL
                     WNEVE"
     gene            11355..12419
                     /locus_tag="KRO40_001078"
     CDS             11355..12419
                     /locus_tag="KRO40_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S ferredoxin"
                     /protein_id="HBH2091907.1"
                     /translation="MKRVDERNTMFARANYKKDSTAYNDYYKKNPDKKEIDDSIRNRP
                     NLCSEGTMTYNELNSPMASSAFDFLSDIKSLCEGKVSDTKVDVDAKSMTKKIKGLAKQ
                     YGASVVGITKLKDYHIYTNRGRHEENYGEEINLTHKYAIVFGCEMDKEMINRAPMICE
                     VIETSKCYVDASIVGMILSYYIRNLGYDARNHMDANYLVMPVFIARDAGLGDIGRNAI
                     LTNKDYGSRLRLGVVTTDIPLLEDEYVDFGLEDFCKVCKKCSFNCPSHSLSNDIKIGD
                     DGKYNWVIEHETCYIKWRYLGTDCGMCISACPFSQNLETIKNTTSFKGNNELIQKALD
                     EYTSKFGKRIFIPGNPSWLK"
     gene            12577..13263
                     /locus_tag="KRO40_001079"
     CDS             12577..13263
                     /locus_tag="KRO40_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091908.1"
                     /translation="MEKILVVEDDSILNKTLSYNLIEDGYIITSKFTAKSALKSIFEC
                     EFDLIILDINLPDKSGFELCNEIKGNYNIPIIFLTANDMECDMIKGYELGALDYITKP
                     FNINIFKQKVKAFLNHLTIKTKQDYYRDGYLEINFSELSANINGNQIIFTPLEYRTLK
                     LLTENPKSILTRKVLLEKLWDIDANFVDEHTLTSVISRIRSKIEKDNLKYIKTVYGMG
                     YMWLGERNEF"
     gene            13253..14284
                     /locus_tag="KRO40_001080"
     CDS             13253..14284
                     /locus_tag="KRO40_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2091909.1"
                     /translation="MNFKKFSFSSIYLIIAVGIIFTAILFSISIYLITADLKLIALLL
                     IYTIVLCGFIALIIFLLHKKIVIFCSKICHTLDSMMNSEDNIEIELEEETILSRINHR
                     LIRMYEVIQENRNSIAIEKADLQELVSDISHQIKTPIANLKMINTTLLNQTFKTEIQK
                     DFLMDMENQLDKLDFLMQSMVKTSRLETGIITLSKKKNSIYETIATALSGILFDAEKK
                     NIEVTVDCDPNLYIIHDKKWTSEAIFNILDNAVKYTNSNGKIRVATECWVMYTKIDII
                     DNGKGISESHQAEIFKRFYREEDVHDIEGIGIGLYLSRKIISLQGGYIKVTSDIGKGS
                     TFSIFLPNK"
     gene            14366..15031
                     /locus_tag="KRO40_001081"
     CDS             14366..15031
                     /locus_tag="KRO40_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091910.1"
                     /translation="MSILQVINLKKYYGQSSNITKALDGVTLSIEKGEFISIVGTSGS
                     GKSTLLNMMGGLDNPTSGKVIIKGKELSTMTDEQLTIFRRRNIGFIFQNYNLVPLLNV
                     YENIILPIGLDGETIDKDFINEIINMLSLEEKLYDMPSNLSGGQQQRVAIARALVTKP
                     AIILADEPTGNLDSRTSSDVLSLLKVTSKKFNQTIVMITHNNEIAQLTDRIIRIEDGK
                     IVN"
     gene            15044..17461
                     /locus_tag="KRO40_001082"
     CDS             15044..17461
                     /locus_tag="KRO40_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091911.1"
                     /translation="MFRNNNRTFIRKIALNDLKINKLKTYLSGIIIMISTCLLLTVTL
                     VSYNASVDLVNASPYHAIYKSVDEKAKNILYKNKNFSGVGTYKLIGSNKKTDCIMSIV
                     YADDTTIKLMNFQPLKGKLPTNKNEIAISEKYLQEFGLDKDIGDSIKLNYYDDITNKE
                     VQCDFIIVGFLENYYQDNAKQYYTVVSNDYFKNIASTPLQNKSNTFDESRPDTVDVLV
                     KLSEENTEKDSASIKTQLKKIGLSLGIKKYNIYLNDNYIESNLIDGEQIITVLVVGIV
                     VLFSSVFVIYSIFYISVVNLVQMYAKLKSLGMTSFQLKKIIFLQGNILSIIFIPLGVI
                     ASCIIAYIIQPLAWQMIADLFIILILSLVMFLTVRISLFKPARIISKISAIEAMQYTE
                     TKFRKKVKNFSYINIKNLALKNIESNRKKNLIALISLSISGVLFISIANLANSIDFKK
                     QLSQQFVYNEDYIISIKSDNLYEHITEIQQNNPLTDSLKNEIKSIHGVKKLIESKLIK
                     SNIIEPYIKDRDEKQFITLIKGITPELSKSLEEYIVSGKIDYTHLDSDSLIINKYRTK
                     YYGLNLKVGDTVTFNIFSGNDIIKKKMKIIGIIDNSNTEGMFFASDKTLESLTPYNTN
                     LDFSILIDKKYSKEVEEKLLSIIQKNSNLMLYSYEDDYRMITRAFQYIIIASYIFVGL
                     ISCFGILNMTNTLINSVLIRKKEFALLQAVGMTRKQLRNMLYREGLNISIKAICTSSI
                     LGYFGSNLLCTFIKDVIRLDFINFKFSIFTILIFSFVLIGIQVLVTELLVRNIEKKSL
                     TERLRSQ"
     gene            complement(17642..18433)
                     /locus_tag="KRO40_001083"
     CDS             complement(17642..18433)
                     /locus_tag="KRO40_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2091912.1"
                     /translation="METKQYLIDFYNTYDEDSRLALKHGMVEFLTTMHYIDKYIKSGD
                     CVLEIGAATGRYSHTLARQGYDVDAVELVEHNIEVFHKNTQSNENISITQGNAMDLSV
                     FPDNKYDITLLLGPLYHLYNKEDKQQALHEAIRVTKPGGVVFAAYVISDGCLIDEGFH
                     RGNINVSEYIEKGLIDPQTFAAKSEPKDLFELVRKENIDDLMSAFNVTRLHYVASDGL
                     ALYMREAVDSMDDDAFALYLKYHLATCEREDLVGVTSHAIDIFRK"
     gene            complement(18466..19053)
                     /locus_tag="KRO40_001084"
     CDS             complement(18466..19053)
                     /locus_tag="KRO40_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091913.1"
                     /translation="MPPKVKITKEMILNTVLDITREVGFEAVNARSIASKLQCSTRPI
                     FTCYENMNELKNEFLAFAYEYYNQYVVNYRNSKSVSPYLLLPLSYIEFAQEETYLFKL
                     LFINDLDLMMKEANDFYKEIDNEKKARLFSESIGIELECAKVIFLDLFLYTHGIAVLT
                     ATKKLTLDRYSAEKMLKNILTAFIRQEKPDWNLSI"
     gene            complement(19229..20620)
                     /locus_tag="KRO40_001085"
     CDS             complement(19229..20620)
                     /locus_tag="KRO40_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate/H(+) symporter BenE family transporter"
                     /protein_id="HBH2091914.1"
                     /translation="MERLARREQPHIKFGMFKIRIPFIHYRFEKPEAIQGIISSMTSL
                     GTIGLSTQILGLPYEVAWSMAIINSILYCLHVFMGDPVVPGWITASITLTTAYLLKFS
                     MGIERIQALTALQIDLGIIFILMGITGVAGKLVSKIPNSIKGGILMGVGISTIISEFN
                     PKGRFDSYPISITVGILVACFVMFSERFDTLKVKNKFLFHLGEYGVVSAILVSLIVGI
                     FSREIEIPRFSFDNLVYIVDFKNLINTVSPFGIGFPSVMLFIQGIPMAFMIYIIAFGD
                     FITGENLVLSESENRKDEYIDFNSNRSNVISGIRNIFMAIFSPYIPMCGPLAATLTGS
                     VAQRYKIGKEAMQSVFSGMGTLVWVSAIFICFYPIAQIATPLIPLALSVTLLVQGYLC
                     TKLSMELCNTGVEKGLIGLMGGVIAAKGGTWGLAVGFILYFILIDSKKRKEKDINSIE
                     DCVYEILDKKKSI"
     gene            complement(20810..22108)
                     /locus_tag="KRO40_001086"
     CDS             complement(20810..22108)
                     /locus_tag="KRO40_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA thioesterase/BAAT N-terminal
                     domain-containing protein"
                     /protein_id="HBH2091915.1"
                     /translation="MKVNVYNVESFVDERLKIMVSDLIPNTKLKISVKMEFPWCKGEE
                     FSSYGVFCSNEKGEVDLDLVEPIEGTYKADNCMGLIYSLEKSKTEGKNFAENISIDKP
                     IIMNMIFETSIERKEVELKRIFKSEDITTKYISDEFIGKLFYKQNSNNKTILMLGGSD
                     GNLDALDLLAAPLASRGFNVLTVAYFALEGLPDKLEEVPLEYFEKVFEWISENEITST
                     KEIFVHGTSKGGELAFLLASRYEQIKKVVVSQPHIYCFQALNGLMSGNDTSSWSYKGE
                     PFPYIKVDNDIFFEEQKKNISKDIPFGFNSTYKKSLKRAENRKEARIKIENSKADILM
                     IAGKEDNIWNSYEACLEALEIFEENNYPYNVELLTYNNMGHPLPIPYIMPLKETLCMS
                     MSGGIFSSGGTVEGNSKGQFESWNRTIEFYKKPLSSDLNN"
     gene            complement(22467..23342)
                     /locus_tag="KRO40_001087"
     CDS             complement(22467..23342)
                     /locus_tag="KRO40_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase"
                     /protein_id="HBH2091916.1"
                     /translation="MITFDVNGAIIRFDDTKNNYNKIRKIFKLYALEISKNFERDCLN
                     SFQNLKQISDRGLSLGEKYIEESFKKGIETIVSFGIITIDIDTFKSVYCEKYLDFKRL
                     FNNLNKTFIIPNKNKKNGHASFLEIESTIKKMSNYLYNDCFKIHYAVVDALIENRITA
                     VHSYIDEESIKKSNALFNNYKDGFIGKADECKVVKQIITLNPYREDVYEFLVKEDGDF
                     SKEIERLTEFLGYDIREYKASLMDIYINELMESDENDVENAKEKIEKYARYIGCSDEN
                     LYVARVNAIYTFANA"
     gene            complement(23535..24221)
                     /locus_tag="KRO40_001088"
     CDS             complement(23535..24221)
                     /locus_tag="KRO40_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF554 domain-containing protein"
                     /protein_id="HBH2091917.1"
                     /translation="MFGVIANSLAIAGGCIVGLIIKGGLPQRVSDTIMNGIALCVLYI
                     GISGALEGKNTLVTIISVAVGALIGELIDIDKWVNKLGAFLQSKFSKGNKKDSIAEGF
                     ISSSLLFCIGAMAVVGSLESGLTGSHDTLFVKSVIDGIASIIFTASLGIGVMFSAISV
                     FLYEGIICVGASFLNGFLSDPVVTEMTAAGSLLIIGLGLNVLKLTNIKVANLLPAIFI
                     PILFGVFGII"
     gene            complement(24270..24803)
                     /locus_tag="KRO40_001089"
     CDS             complement(24270..24803)
                     /locus_tag="KRO40_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBH2091918.1"
                     /translation="MSDLNNKKEQDENESSMNETKIYDILDKLNVEYDVVEHEAVYTA
                     EQLVILDGITKGCQCKNLFLRNAKGNKYYLIVVKGEKQVDLNSLKDKIGSSRLSFASP
                     ERLYNVLKLLPGSVNPFSLINDTERKVELYIDKDVIKEDYLNFHPNINTKTVNISRKG
                     FEEFLEYLKYPIQSIDV"
     gene            complement(24847..25479)
                     /locus_tag="KRO40_001090"
     CDS             complement(24847..25479)
                     /locus_tag="KRO40_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclase family protein"
                     /protein_id="HBH2091919.1"
                     /translation="MKVFDLTHVTHNDMPVYAEPNRPDIKKVAIIEENGYQETLISVF
                     SHNGTHMDSPRHMYTKGETLDKLDIENFVGKAYVLELEKGNENIELEYLKKYEDEIKN
                     SDFIIFKSGWSKFWDKKQYYVGYPTLTKEAANYIANTNIKGIGIDMLSVDRYDTSVFE
                     VHHILFEKGKIIIENLTNLENVPEKFLFIAAPFKYNDADGAPVRAIAIVE"
     gene            complement(25569..26648)
                     /locus_tag="KRO40_001091"
     CDS             complement(25569..26648)
                     /locus_tag="KRO40_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HBH2091920.1"
                     /translation="MKIAIFLGAGASAAENLPIQNELFSEYFKKLNPTNYNTKMNREL
                     YIFFKQMFNIDIVKDNIDNANFPTFEEVLGLLDLAEQRKEAFRNFGLENLNNRSDSIR
                     FLRQYLILLMAEAIHNTPRTDNKYHKLLVENLLENDLLLDTTFISANYDIHIDNTVTG
                     LRDKNDLPIMLDYGVEFTNFKEELNWRKPKEPLIKLYKIHGSLNWLYCPICNSVTLTP
                     HEGGVMKLIENSSETKCLECGELTEPIIVPPTYFKNMSNIFLSNVWNETEKTLRDTDL
                     LIFCGYSFPEADMHIKYMLKRVQTNRKKPPLKIMVFNNHSQKQRITLKKEEGRYKRFL
                     GEDVIFTDNSFQDFSVNPLRFIKNI"
     gene            complement(26781..28127)
                     /gene="pepV"
                     /locus_tag="KRO40_001092"
     CDS             complement(26781..28127)
                     /gene="pepV"
                     /locus_tag="KRO40_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HBH2091921.1"
                     /translation="MKEQIKEKVNSLQDEMISSIQESVKIPSVISEATENCPFGENVD
                     KALRGILDLCKSLGFKTVYKDGYYGYAEIGQGEKMIGILGHVDVVPEGDLESWNYPPF
                     EAVLEDGKLYGRGTQDDKGPTISAIYAVKALMDLNVDFNKRIRFIFGADEENLWRCIN
                     KYKENNEEIPNYGFTPDSRFPITNAEKGLLQVHLTCDSKSDIELSVGKALNAVPGKAI
                     YIGKYSDKLKKELDKLNFEYTVEGNKICIIGKSVHSAASDTGINAVARLCIALNNIGI
                     DSNIIKFLAEVIGEDANGNNIIPNCKDDVSGKLTVNIGRVTIDNEKEFAGIDVRIPVT
                     YKKDDFVKELKKMTDKYNLNYEEYDFLDSIYVPEDTLLVKTLRKVYEEETGLDGTPLS
                     SGGATYARALDNCVAFGAIFPGKPETEHQANEYLIVEDIIKATQIYALSIYELLKI"
     gene            complement(28196..29476)
                     /locus_tag="KRO40_001093"
     CDS             complement(28196..29476)
                     /locus_tag="KRO40_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine gamma-lyase family protein"
                     /protein_id="HBH2091922.1"
                     /translation="MLNETKELLKDYYGIDDDTFKLSQEIMEEIKDKFEEIKEIREYN
                     QYKVLKAMQESKLSDMHFNWTTGYGYNDIGREKIEEIYSKVFNTEDALVRPIIVNGTH
                     ALTLCIQGIVRPGDEILSVTGRPYDTLEGVIGIREEKGSLKEYGVTYDDVDFLEDGNL
                     DLEGIKSKINDRTKLVMIQRSKGYSWRKSLSISDIKEAIEVIKSVKPEAIVMVDNCYG
                     EFLDTKEPTDVGADVMAGSLIKNPGGGLALTGGYIAGRKDLIELISYRMTSPGIGKEC
                     GLTFGTTRNVLQGFFLAPYIVSQAVMGAIFCSRAFEKLGYDVLPKYDDLRSDIIQCIR
                     LNNADEVISFCEGIQEAAPVDSYVKPVPWDMPGYESEVIMAAGAFIQGSSIELSADAP
                     IRPPYNVYFQGGLTFDHSKMGTLKAIEFIKKLKK"
     gene            complement(29603..29863)
                     /gene="hfq"
                     /locus_tag="KRO40_001094"
     CDS             complement(29603..29863)
                     /gene="hfq"
                     /locus_tag="KRO40_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA chaperone Hfq"
                     /protein_id="HBH2091923.1"
                     /translation="MKNTVLNLQDLFLNNARKERIPVTIYLVNGVQVKGLVKGFDSYI
                     ILIEGDNRQQNMIYKHAVSTIQPGKYINLTNQNQNNNNNNNR"
     gene            complement(29977..30912)
                     /gene="miaA"
                     /locus_tag="KRO40_001095"
     CDS             complement(29977..30912)
                     /gene="miaA"
                     /locus_tag="KRO40_001095"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HBH2091924.1"
                     /translation="MKKIPLIILTGPTAVGKTDLSIKLAKDMNAEIISADSMQIYEYM
                     DIGSAKVTEEEMQGVKHYLIDEVKPDYPFSVSEFQQRAKKYIHEINEKEKCVLVTGGT
                     GLYLNSLIYNMDFAQSDANNELREELQKQLAEKGIDYMHNKLKELDEESANRIHKNNT
                     KRVIRALEVCLSGKKMNDFSSDLKFNEEYQPIIIVLNRDREHLYQRINMRVDIMIKNG
                     LVEEAKKLLSMGFKKDMISMQGIGYKEILKYLDGEYTYEEAIEIIKRDSRRYAKRQIT
                     WFKRYKTAKWFDLDQYENIDELKNEIILYIKDSIK"
     gene            complement(30950..32917)
                     /gene="mutL"
                     /locus_tag="KRO40_001096"
     CDS             complement(30950..32917)
                     /gene="mutL"
                     /locus_tag="KRO40_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HBH2091925.1"
                     /translation="MKNIINILDDLTINKIAAGEVVERPSSVVKELIENSIDAGANKI
                     SIDIIDGGKSLIKITDNGIGIPSSEVEKSFLRHATSKIKKIDDLYDLYSLGFRGEALA
                     SISAVSKLEMTTKTKDEIIGTKIYVEGGKIISKEPIGSTNGTTIIIKDIFFNTPARQK
                     FLKSTHAETINISDLINKLAIGNPNIQFKYTNNNKQMLNTPGDGKLVNTIRSIYGKEI
                     TENIIDVEFKCNHFKMNGYIGNNNIYRSNKNLQHIYINKRFVKSKIIIDAITESYKSI
                     IPIGKHAVCFLNIEVDPSCIDVNIHPNKLEIKFEKEQEVYIELRDFLKVKLIHSNLIG
                     KYATYSDKKTQPRIAINSREKSTDYKLRNNDLLESTPKNSNITKGKDEVIEVVTLSSE
                     KPINEFQSVSEVLNASVEDDVKNINYLSEDSANDNIQEEFQVDGIKNEGNYYLGDSIK
                     DSEEEYLCSSKRKFSLYGYFVIGVVFNTYIILSKDDSMYLLDQHAAHERILYERYMEK
                     FYRQDINMQILLDPVVIEVSNIDMLQIENNLELFMKFGFELEIFGNNHIMVRCVPTIF
                     GVPETEKFILQIIDNIEEITSNYDLKGERFASMACRSAIKANDKIYDIEIKSLLEQLE
                     KCENPFTCPHGRPIMVEISKTEIEKMFKRIM"
     gene            complement(32928..35771)
                     /gene="mutS"
                     /locus_tag="KRO40_001097"
     CDS             complement(32928..35771)
                     /gene="mutS"
                     /locus_tag="KRO40_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HBH2091926.1"
                     /translation="MQIDMNKLTPMMKQYLEVKNRYKDCILFFRLGDFYEMFFEDALV
                     ASKALEIALTGKACGLEERAPMCGVPFHSANSYISKLVENGYKVAIGEQMEDPSTAKG
                     IVRREVIRVITPGTVLDGNLLENKKNNYLLSLYKDGTNIGLTYVDISTGETNATCLNE
                     DKVIEEIAKIHPTEIIINDLDFIEKLRDIATVSNIYINESFSDNYLDINILKEYFPDV
                     YLQKLKFDDKGLIKSSLSILLNYIYNTQKQITSNINNINIYNSSEYMVLDMFTRTNLE
                     LTQTIRGNKKKGSLLHVLDKTSTAMGGRLLRKYVEEPLINKSKIENRLDVIEEIKDDF
                     ILREDLNDILKNIYDIERICGKIAFERVTPKELIHLKNSIEKLPNLKDTINLSNAKIL
                     KEYVSEMDKLDDIYNLIDEAILEEPTITIKDGNIIKSDFSDELKELREISKNGAFLVK
                     EIENREREKTGVKSLKIGFNKVFGYYIEITKANFKQAKLDETYIRKQTLSNAERYITP
                     ELKEIEEKILHAEEKIKSLEYEIFVEIRDTIYKNIDRIQKVAKTIANIDVFVSLATVA
                     HINNYVKPAINENNKLDIRNGRHPVVENIVGEENFVPNDTYLNRGENIINIITGPNMS
                     GKSTYMRQTAIIALMAHIGSFVPAESADIPILDRIFTRVGASDDLSQGQSTFMVEMNE
                     VSLILKNATERSLVILDEIGRGTSTYDGISLAWSIVEYIQKNIRCKTLFATHYHELTD
                     LEEEFKEVKNYSIAVKEDGEGIIFLRKIIPQGADKSYGIYVAKLAKLPDEVIERAKYI
                     LKDLEKNHVYNSVAINGDKENNNIINSNLDEELVKVNQSNFKNKYESLKIEHELIVKD
                     YKHIKKDYDKLNSKFKALNDEVALMKQNDDKEKINQEDSVKEVALTQISFDSVNRDIL
                     SEEILNLDILNMTPLDAINSLYNLQRKAKEIKS"
     gene            complement(35932..36666)
                     /locus_tag="KRO40_001098"
     CDS             complement(35932..36666)
                     /locus_tag="KRO40_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2091927.1"
                     /translation="MLTQMNFYHNKKVKVSIENVSKTYKDIEVLKDISIDVYEGEFVS
                     ILGPSGCGKSTIFNIITKLTDYDSGKVNINGKYSYMYQKDLLLPYKTIIDNVSLPLIL
                     KKEKKSKARSMVKPYFEVFGLSGYEDKYPSELSGGMRQRANFLRTFINSNDIMLLDEP
                     FGALDSLTKTSMQKWLLDVKKKVNSTILLITHDIDEAIMLSNRIYVISKKPSIVKKEF
                     VIDSRKLNEDNLENIIKLKKEIISLL"
     gene            complement(36635..37648)
                     /locus_tag="KRO40_001099"
     CDS             complement(36635..37648)
                     /locus_tag="KRO40_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2091928.1"
                     /translation="MNFKKLGILGLVSVFTLATITGCSSNNNKDKNNDKDTSSKKVTM
                     VLDWTPNTNHTGLFVALDKGYYKEEGLDVEIVQPPESGAETLVATGKADFGISYQEQV
                     TYAKTSEDPLPIKAVATVIQHNTSGFASPKEKNITTAKDFEGKTYGGWGSPSEEAVFK
                     AVMKKNGADFNKLKIVNTGQDDFFAAMKTVDFAWIFEGWDAVKADLIGYDLNFIPVKD
                     LDERLDYYTPLIISNETVLKNNPELAKKFLKATTKGYEYAIKNPEESAKILVKHAPEV
                     DEKLALKSQEYLASKYKDDAPRWGEMKDSVWNNYTSFLKEYKLIDKDMKASDAYTNEF
                     LPQ"
     gene            complement(37670..38440)
                     /locus_tag="KRO40_001100"
     CDS             complement(37670..38440)
                     /locus_tag="KRO40_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2091929.1"
                     /translation="MKNLEIIDKVKDSIYPIATFLFILILWQSMVGVLEVPQYILPTP
                     VDIINVFFKDYQNLSIHAVVTIGEAILGFIVAIIISLVIGILMDFVSIIKKCLYPIML
                     VTQMIPTIIIAPLFMIWFGFGTMPKVLMVMLTCFFPILISFVDGIENIDKDYLNLFKT
                     MDSNKVNTFIHLKFPMAMDKFFSGLKISATYAVMAATVAEWLGGTKGLGVYMLRSKSA
                     YALDKVFASTILVVIFSLMFVGIVQAVKKVVIRHRLID"
     gene            complement(38415..38705)
                     /locus_tag="KRO40_001101"
     CDS             complement(38415..38705)
                     /locus_tag="KRO40_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MTH1187 family thiamine-binding protein"
                     /protein_id="HBH2091930.1"
                     /translation="MVIADIAVMPLRPYKGEEEMYKVVDACIAEIEKSGLKCEIGAMS
                     TTVEGDFDEVFELLKKVHKIPFNLGCERVITVARVDEKAGGLTIDEKLRNHR"
     regulatory      complement(38836..38935)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     regulatory      39555..39644
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            39697..39873
                     /locus_tag="KRO40_001102"
     CDS             39697..39873
                     /locus_tag="KRO40_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091931.1"
                     /translation="MFMDKMDRCTHILTAYICSSRDYCNFIDTQLNDFILEYGENVVE
                     SCLHQVMVLVSRYN"
     gene            complement(39988..40344)
                     /locus_tag="KRO40_001103"
     CDS             complement(39988..40344)
                     /locus_tag="KRO40_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2091932.1"
                     /translation="MDIDNNFEEFPNIEERQKDFNCSIGFTMTVIGSKWRAIILWHIL
                     KQEPIRYSQLKKEVVHISHKILSQELKYLERDGLIKRISYPTIPPKVEYLSTKRGKSL
                     ESILLELCNWGKQYMR"
     gene            40600..41513
                     /locus_tag="KRO40_001104"
                     /pseudo
     CDS             40600..41513
                     /locus_tag="KRO40_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007061260.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family isomerase"
     gene            41744..42355
                     /locus_tag="KRO40_001105"
     CDS             41744..42355
                     /locus_tag="KRO40_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA pyrophosphatase"
                     /protein_id="HBH2091933.1"
                     /translation="MINDIKNKFKNYKPYINGYKNMKRASVLIPIVEINNTHYILFEV
                     RSKNLKHQPSEISFPGGKIESGETPYEAVIRETCEELGTFSDNIEVISSLDLLITPVK
                     FIIHPYLGYIKNINNLNINKDEVDHTFLVPIKYLLENPPNTYSNTVKVFPDENLPYGS
                     IPNQKDYKFESGSYPILFYKYKDYVIWGMTAKILENFLNFLSE"
     gene            42653..42991
                     /locus_tag="KRO40_001106"
     CDS             42653..42991
                     /locus_tag="KRO40_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3784 domain-containing protein"
                     /protein_id="HBH2091934.1"
                     /translation="MFAVGFVVIIALAFFILSVLLFNGKASMLLAGYNSMSKKEKARY
                     DKKKLCRSSSIVTFIVSIMLFIMAFLGYRIESGQMDEKKMVPFSIIFIIVILSSVFFN
                     ILYSNKKCKK"
     gene            complement(43398..44834)
                     /gene="miaB"
                     /locus_tag="KRO40_001107"
     CDS             complement(43398..44834)
                     /gene="miaB"
                     /locus_tag="KRO40_001107"
                     /EC_number="2.8.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (N6-isopentenyl
                     adenosine(37)-C2)-methylthiotransferase MiaB"
                     /protein_id="HBH2091935.1"
                     /translation="MSKRKQVTIPIEKIQEQDKYIEQIHRQNEEYFNRTGKRKLVFTQ
                     TFGCQMNEHDSEKLCSMLEEMGYQMSMMVEESDLIIYNTCAVRENAELKVYGNLGQLK
                     HLKGKNPDMKIAVCGCMMQQPHVVEELRKKYKHVDLIFGTHNLYKFPQLLTESINSDK
                     MLVDVWDVDGEVIEGLRSNRKFELKAFVNIMYGCNNFCTYCIVPYTRGRERSRTPEDI
                     INEIKELVANGTKEITLLGQNVDSYGKTLENPVSFSELLRKVNDIEGIERVRFMTSHP
                     KDISDEVIYAIRDCDKVCEFLHLPIQCGSSSLLKKMNRHYTKEYYLEIIEKAKKEVPG
                     IAFSTDLMIGFPGETEEDLLDTLDVVEKVRYDSAFTFIYSKRQGTPAAKMENQIPEDI
                     KHDRFNRVLEAVNRISAEINDGYKDRIVEVLVEGRSKNNENKFAGRTRQNKLVNFEGG
                     NDDLIGKLVMVKITEPRTFSLNGILVNN"
BASE COUNT        15339 a         6921 c         5186 g        17490 t
ORIGIN      
        1 ataatctatc aaccttaata tattttttat ttgaccttaa ttaaccttaa ttaaatagga
       61 aaggtgatat aaaatgagct acctaatcca ggtatacttt caacagatat attccctcca
      121 tgaacttcaa taatttgctt cgttattgct agtcctaaac cagttccttc tattttttgt
      181 tttgtattgc ttcctctata ataacgatta aacaaatttg atgcttcttc tcttgacatc
      241 ccttttccat tatcagatat aatgatttca attctttcat ttaatgttat atgtacacaa
      301 actttagtat ttttatatcc atatgtaaaa gcattgacaa taagattact aaaagctcgt
      361 tttaatagtg tacaatcaaa atcaaagtta atattatcta tattactctt aaattcaact
      421 atttttgatt catattctgg ataatttaaa atatcaatgg ataattcttt caaaaatctt
      481 actaaatcat aattattttt atttaaaggg attattccat tttttaattg ataggttaat
      541 tttaaatcgt ttataagtgt atttgtatat tctatgttct ttaacatgat tgaagcatat
      601 ttatatactt tttcaggtga ataattagta ctactatctg taagaagctc tgcataccct
      661 tttattggtg aaagtggagt ttttaaatca tgagttatat ttgaaatcca ctcttctctc
      721 ataatatcag ttttattctg tatctcatca cttttatgaa tttcttcatt taaaatattt
      781 aaactattat atatatcagc aaaaacacct ttaatattaa ctggaagata gcttcgtttt
      841 gaaatatcgc taacagcaga tgtaatattt gatatgcact ttgttaccca gtaaccataa
      901 gcaattccag aaaccaaaat tattaaaaat ataatcccta tgattgaaaa tacaattgac
      961 ttaccaccta taaatttacc tccatcaaaa aacatattca ctttagatat atttaatgga
     1021 aaatatataa tataaatata gtcattttta ttatttttaa ttgtattaaa gtatacagtt
     1081 ccattacttg aattattttg gttagctaat gctaataatt cagaattaga ataataatct
     1141 ttatgctctt ttggttctaa aaacccataa actctatttc cactagaatc taaaatttgc
     1201 aaccacaatt gattttctcg aagtttttct aatccagact gttttacttg tggcttatta
     1261 tctataaata cgatttgttc attaaagttt tctgtaaatt ttttcggcca atcactacga
     1321 ataaattcac catttggttt ctgaatagta ataagtgata agaaaatacc tattactgtc
     1381 aggattaagc aaataaaaat catgaaaaaa ataatgtatg aatgaaatac tgttttataa
     1441 ctaggtttat gcatttaatc aactcttttc ttaaactttt attttagttt gattgttgct
     1501 tatataaaat agacaataat tattgatatg taaaaattta tttaaaaata caactatcta
     1561 cataaattat atttatataa ttatatgtta tcaagctgtc tgttgtattt aataaatcat
     1621 tttgataaca tataaaagta agataaattt ttccattaaa taccttataa ttatacacaa
     1681 aatctctata tacgttaaac agtatagaga aaattttcat agaaccatct ttatagggga
     1741 tactttataa aagaataaaa aaattataat atataaaaac ttcataggag tgtaacaaca
     1801 tcagtaaaaa tatgaaaaca ctatataaaa attcaaaaat attaagaata atgaaatact
     1861 tgaaattgct tatatcaaga aattttatat aatataaact ggtcaaatat gttataatat
     1921 taaattgtga caagttcatg gaggtgttta tatgaaaaaa caaaagtcgc caattttact
     1981 tgaaatgctt ggactatttt ttggttgtat atcaatgagt attggtataa atatgttttt
     2041 aaaaccacat acaattgctc ctggaggact tagtggtcta tcattagtac taaacaaggt
     2101 tacaggactt ccagtatcag ctatcatgtt aattataggt gtcccattag taatacttgc
     2161 ttttagaatt atgggtacaa aaaattcatt aaaaacttta tttggaacag ttgtattttc
     2221 agctatagtt caattaacag acccattatc aaaactaaga tttactaatg acttattatt
     2281 gtcttctatt gcaggaggaa tcctagttgg tataggttta ggaataatgt ttaaatcaga
     2341 tgcttctact ggaggaacag acttaattgc actcatactt agtaagaaat tcccaggaat
     2401 aaaagctaca aaattcatgt catgcctaga tggaatggtt gttatatctt ctggtatagt
     2461 aaatcgtagt ttagaaactg ctctttactc tggtatagca ctttgtgtat taataaaaat
     2521 agcagatatg ataatggaag gatttgacca ttcaaaagca ttttttatta tctctgatga
     2581 acctgaaagt ttaagacaag ctataactga agaacttgat agaggtctta ctattcttga
     2641 tggtaaaggt ggatacacta gagaaaataa agaagttcta ttagtcgtag tttctaaaaa
     2701 acaagaactt tatctaaaga gattagttaa aagaactgac cctactgcat ttgttattgt
     2761 tacagatgta catgaggttc ttggagaagg atttaaaaat ttagagaact aataaaaatt
     2821 aatattttaa gtatatatac tattttaatt aaaatacgat ttattcaaaa agagtgtctc
     2881 ataaactttt tagttcatga gacactcttt tttgtataaa atcaaatgca ttttcagtat
     2941 tttaacaata aaaacaggat tatctatatt ttgaggcaac cactttattg aaattttatt
     3001 tagaaaacaa tcattactaa ataaccagca tagatattaa atgattatat ctattgtttt
     3061 ttcaattcat attgataaca aggaacattt tttacagtat ttccagtatg aatttttttg
     3121 atatactttc ctgtacattt aaatcctaat aaatctaatg attttttaga attttggttt
     3181 tcttcatagg ttattgcaat tattttattt aagtttagtt ctctaaatcc atactgtatt
     3241 actctttttg ttatctcagt agcaaaatca tgtccccaat agctcggatt tatacatata
     3301 cctatttctg cttctaatgc tttaggattt atattattaa accccatatt cccaataact
     3361 ttattgtctc ttttatatac tatagcaaag tggccaattt tccctttttt atatggattt
     3421 agaaaaaatg attttataaa ctttcttgta tcttctaaag atttatgctc actaaatggt
     3481 aaatgtttta ctactatttt atttttataa cagtcaaaaa aatcttcaac atcatctaat
     3541 gatgcaggtc ttagtataca acttctagtt tctaaggttt tcatttgagg atattcagaa
     3601 tcagacattt ctaatccccc tttatacatt aatctaaata tactgttcat atttaaaata
     3661 cgatattaat tatataaatg ttctcaaatt aaccttattt ttatttttaa taaaaactaa
     3721 ttactatatg aatctttcaa gtttacgaat ttatctctat ttttatatta aattacttgt
     3781 gaaatatgta ttctaaatta tatattatta gatatcatgc ttaaaaattc tttggttgct
     3841 aaggataaag atatatcttt taaatggcag taacctatat ttctcttagg tattggctct
     3901 tttatatcta atttaaacaa tttctcattt tccaaataat ctatgctaaa ttcttctata
     3961 acacaagaca ctccaagatt tatatacgca aattctaaaa gtaattcatg agaacccaat
     4021 tctatatccg ggtttagttt tatacctttt gataaaaaat attcatttac ataaagtctt
     4081 gaatttgctt tattttctag cattattaaa ggcaatgtgt ttaattcttc caatgatatt
     4141 ttcctacctt tgtattctat gtaatcattt gcacatacaa atatatcatg tatttcaata
     4201 cactcaacaa tatttagtgt atcatcttct attggcatgt ttataattgc tatatctata
     4261 ttcccatctt tgagtaaaga tataagttct ctactcgttc tatttattgt agatacatgt
     4321 atatgtggat acttcttatg aaaaatttct aaatatttta acaagaaaaa acgtgcagct
     4381 gtatctccta ctcctatttt cagagaaccg tattctaatt ttttaaattt atttattcta
     4441 tcttctcctg atgatattaa ctttaatgca gtagtgacat gttcacttag aattttcccc
     4501 tctggagtta attttactcc cttattgttt ctataaaata ataaagtatc taattgttct
     4561 tctaattgct ttattgactg gcttacagct ggctgtgaca taaacaattc cttagcagca
     4621 agagaaaaac tcttattatt tacaactgca ttaaaaacct tataaagttc aagttttata
     4681 ttcatatata attactcctt atgtcaaata ttagtattat ttattttact tataattata
     4741 tttgaattat aatatacatg gtactaatat gacaatatta attctttagg aggattttag
     4801 ataatggata gattagttgg aactgtttca agaggggtta gagcacctat tataagacaa
     4861 ggagatgact tagttaaaat agttgttgat tctgttttaa atgcgtcaaa aagtgaaaac
     4921 tttgaagtta gggacaaaga tgtaattgcc gttacagaag ctgttgtagc tagagcacag
     4981 ggaaattatg ctcacgttga caatattgca aaagatgtaa aagataaatt tggagatgat
     5041 actgttggag ttatattccc aattttaagt agaaatcgtt ttgctatatg tttaaaagga
     5101 attgcaaaag gatgtagaaa agtcgtatta atgttaagct acccttctga tgaagttgga
     5161 aatcacttaa taagtattga tgaacttgat gataagggaa taaatccttg gtcagatgtt
     5221 ttaacagaag aaaaatacag agaactattt ggatataaca agcatacatt tactggtgta
     5281 gattatgttg attattataa gaatttaatc aaggattgtg gtgcagaggt agaaatagta
     5341 tttgcaaaca atccaaaaac tattcttaac tatacaacaa gtattttaac ttgtgatata
     5401 catacaagac aaagaacaaa gagaatttta agacaaaatg gagctaaaaa agtatattca
     5461 cttgatgata taatgacagc aagtgtagat ggtagtggtt acaatgacca gtatggactt
     5521 ttaggttcaa acaaagctac agaagaaaca gtaaaattat tccctataaa ttgtgatgaa
     5581 gttgtaaaca aaatccaagg taatataaaa gaaataacag ggaaagatgt agaagtaatg
     5641 gtttatggag atggagcttt taaagaccct gtaggtaaaa tatgggaatt agctgaccca
     5701 gtagtatctc ctgcttatac aaaagggcta gagggaactc caaacgaagt aaaattaaaa
     5761 tacttagcag ataatgattt tgctgactta tctggtgatg agttaaaaga agcaatttca
     5821 aaatacatag ttgaaaaaga taataaatct gatgatttaa caggaaacat ggtttctcaa
     5881 ggtactactc caagaagatt aacagacctt ataggttctt tagcagattt aacatctgga
     5941 agtggagata agggtactcc tattatttac atacaaggat atttcgataa ctatacaaaa
     6001 tagtatgttt taataagatt taaatttttt ggattatata tattaacatg aaaatttatt
     6061 aaaacctctt aatagatatg acttttcaag agttatatct attaagaggt ttatttaatg
     6121 ttcacagata agatatattt aaataattta aacaagattg tcagaaagtt atataatctt
     6181 aaaaatttat ataactctaa ttcttattta tttctgaaat aatatcactc ttcaaaattt
     6241 gtcttactgg aataattaca gcaactatac taatagtgat atttaaaata atcataccta
     6301 tgtatagagg tgtatttatt ttaagaattg gatttatata taagtataca cgttttacca
     6361 taaaataaat cataaattgt ccaataacac ttccaattac cattataata cttgcataga
     6421 atccatataa aaaaccttct cttatcatca taagtaaaaa cttattatcc gtaataccca
     6481 tagctcttaa aattccaaac tcatgtcttc ttgaaaaaat taagtagctt actgtattga
     6541 ttatatggaa caaacttatt gcaagaagta caaatacaat accatatata aataagagtt
     6601 tttgatttaa gtaggtatta tttttttcaa tagcaatggt ataatctgtt acaatacatc
     6661 tttttacatc acttacaaca ctttttatgt tctcagacaa ttcctcactg ttactatctt
     6721 ctgtcttttt tatacttact gaattataat tttcgatatc aaagttattt ttcatttgcc
     6781 cattcgtcat aactatatcc ataccataat caccaatgaa atatatgtta tttgccatca
     6841 cacgttttac agtagcagca actacaaatt cttttgttgt ataatcattc ttattttctt
     6901 ctttaaattt aacaatttca tctgttggtt tcattgtctt tggcacttta acttttattg
     6961 tatctcctgg atttatatca actgcatcat acataccagt tccatccata ggtagtctaa
     7021 ctataacctt attattttta accatatcat gggtattaat ctccccatct ataatataag
     7081 aatttaatcc ttctaacata ccattgttat aaccataaat atttgttttt aaaagatagc
     7141 caccttcatt ttgctttgta caaataccat caaaaaaagt ctttatcctg taatcttttt
     7201 caagaggttt aaagaaattt ttccaaaata gttgttcttc tttaatttgc atagctccaa
     7261 ataaatatct tactggatag acttttgata ttccctcaac attgtttaat cttgaaattt
     7321 tatcttttgg tatacctaca tcaaaatctg ttgtttgcat agttatttgg tagtcagaat
     7381 ttaaaccatc atcagctttc attgtaagtt cattattatt tttagtaagc tgtatagagt
     7441 aactagaaca tagaaatata attccaccaa gtgataatga aaacaaaatt ccaataaaca
     7501 ttcccttttt ttgagtcatg tatttatgag ataatacttt tgtcatgtta gagtgtttta
     7561 cactttctaa tattctcttt ttcttattag taatcttaaa gtttttcata gattctatac
     7621 tagagtattt attcaactga tgtacaacac gtacagcaat taaaattaac aacaataaga
     7681 taaataaaaa gcctaaataa atagattttt cacttataaa aaatgctcct ggaacaatat
     7741 cactactcaa aaatatatgt ggaaattgtt catatattgt agacgccact tcaataccta
     7801 agaagcaacc tataggaaat ccaacaataa aaagtaaaaa taactctaaa aatagtagaa
     7861 ataaaagttg tttattatta gcgcctaata cttctaaaac cccatattgt gatattctct
     7921 gaagtattga aacatggaaa atactatata ctgctgctgc accaaacact ccaacaagta
     7981 atataattgc atttgtattt agttctaaat tttttaagaa ctcaaatata ttatattttt
     8041 ctatattttt tggtggtttt actccaaatt caactgaaag aggccagttt atataagttt
     8101 tttcttttga tatgttgaat tttttcataa atttataatt ttgcttttta atatttttat
     8161 tttcatcata ttttacataa actatataag aatccttttc tttaggctga aaataatcgt
     8221 ttacaaatcc ctccagagca gtttctgggt ttgaaagact tgataaaata ccacataact
     8281 tatagatttt accatctaaa ttgatttctg ttccaatttc tttgtttaca tttaaattgt
     8341 ttagagaata tgtgtcaagt actatctctc catctttact aggaagagtt ccttttaata
     8401 attttctacc tgtcatgtct aaatatgaag aatcagcatt taaaaattct ataataaaag
     8461 gttcatctat ctgattttta ggttttgtaa tgccaagtct atctacagtg tattcctttg
     8521 attttttatt ttctttaatt ttattaagtt gttccttatc tactttatag aaataatgat
     8581 aatctccact atcttccctt atcttttcaa ttctactttt gtctgcacta tgaactaaag
     8641 aaccaattcc cgtcaataat gctactgata gtactatgct taaaactata gatatagatt
     8701 gttttttata atgctttata tattgaattg aaaattttac tagagacatc atagtacttc
     8761 accaccagta ttcaccacaa ctccatcttc aatatggata attgagtcgc atacttgtgc
     8821 tatattttca ttgtgtgtta ccataagtat cgtttgatgg aattttgcac tactttcttt
     8881 taataaacat accacttcca ttgtagtttt actatcgaga tttcctgttg gttcatctgc
     8941 taatataagc gcaggtttat ttgccaaagc tctagcaatt gctaccctct gttgttgacc
     9001 accagatagt tcgcttggaa attttaaacg cttatcccaa attcccaatg tcttcatcag
     9061 catttcaata tattcatggt ctatatggtt tcctttatct aatgtaacag gaagagctat
     9121 attatcataa gtgtttaata cgggcattaa actgtagttt tgaaatataa atcctatatt
     9181 tcttcttcta aatactgtca aatctttttt tcctatttta gatatgttct ttcctttaat
     9241 tattacatca cctgaagttg gattatctaa tccacctata atatttaaca atgtgctttt
     9301 tccagaacca gaagttccaa ctatagcagt aaatgtatct cgttcaattt ctatacttac
     9361 tccatttaag gcttttactt tagtctcacc ttttccatag tgttttacta aattattcgt
     9421 cactaatata ctcatttaat ttctcctttc aatacagata tatgttctat aaaatattgt
     9481 aagtgacgat aattacactc atcctacaaa attagtttaa actcttacaa ttctgtaaga
     9541 agatactaaa acaacatcca cttcctagtt tagattctac tataatgttt ccattttctt
     9601 tttctaaaat taatcttgta agatatagac caatccctgt gccattttgg ttttccacat
     9661 ttttacttct gtaaaatctt ttaaaaatat catttagttc tctactatca atacctattc
     9721 cctcatcttt aatagtaatc ttcgtatata gttccatttt tattacagaa atagtaatcg
     9781 tgctatctga tggtgagtat tttattgcat tttctaaaac atttacaatt gcttctatgg
     9841 tccacttttt attatgaact aactttatgt ctgaaaatgg ttcgagattt atccttatat
     9901 ttttagcttc tgctttatta aagatagtac tgatactttg aataagagta tctttaatta
     9961 gtagttcttc tacttcaaat tctataactc catcctctaa tttagtcatt ttaaataagg
    10021 attgtaacag ccagtcaatc ttaaaagttt catttttcat cttttgtaaa aactccttct
    10081 tctgtaatgt ggaaatattt atattctcca gaagttcaca ataaatggtt atatttgaaa
    10141 gtggagtttt taattgatgt gacatatttg atattaaacc tttaatcgct tctttttctg
    10201 actttgactg ttctacctct atttctatca tatccttaat tttttttact tggtgagaaa
    10261 tttttgacgc tcttgtatcc tttgtatctg gataagtaac ttctttacct tccaatattt
    10321 gatttaacat caaatttaat tcatcatatc tttttcgatt tattttagta gatactataa
    10381 atataacaac tgtacatatt ataaaggcta atataaacat attattctac ctcattccat
    10441 aaataaccca ttccataagc tgtttttata tattttggat tagatgggtc atcctctact
    10501 tttactctaa gtcttcttat atttacagat acaatattat catcaacata attttcttcg
    10561 ctgtcccaaa tatggtgtaa aatttgttcc tttaataata tttgaccttt attttcaatt
    10621 agataactta gaagcttata ttctacagag ctaagttcca aacattcttt atttttatat
    10681 acttttagta acttttggtc caattttatt ccattggaat atattacttt attattcgat
    10741 ttttttctta ttgctacttt gactcttgcc tttaatacag ataaagaaaa tggttttgta
    10801 atataatcat caagccctat ttctaatcct tttacttcat caatttctga gtctcttgca
    10861 gtaagcatta taattggtat atctgacttt tcccttatta tttgacatac atcaaatcca
    10921 tatccatctg gaagattgca gtctaagatt ataaaatcta tatttttact attaaatata
    10981 tttaatcctt cttgttttgt ataagcctta aatacattaa atccatcatt ctcaaatgca
    11041 taaaaaagac cttcatttaa gtttatatca tcttcaataa ttaataagtt caattttact
    11101 ctcctttaga ttttttagat aaataattat tttcttgcat tatcatacta aaaatatttt
    11161 aattttattt atttcactaa aaagattgta tttaaatttg ttttcaaaat aaaaacatca
    11221 taatcaagca tatagttata tatttcccaa tttaattacg cttaaattga aaatataact
    11281 ttattcttat ataattaaat tatacaacaa taaagttata ttttttaaat atatttttac
    11341 tagggggaat agaattgaaa agggttgatg agagaaatac tatgtttgca agagcaaatt
    11401 acaaaaaaga tagtactgct tataatgatt attataagaa aaatcctgac aaaaaagaaa
    11461 ttgatgatag tataagaaat agaccaaatt tatgtagtga aggaacaatg acttacaatg
    11521 agttaaactc tccaatggca agtagtgcat tcgatttttt atctgatatc aaatctttat
    11581 gcgaaggaaa agtttctgat actaaagtag atgtagatgc aaagtcaatg acaaaaaaaa
    11641 ttaagggtct tgcaaagcag tatggagctt ctgtagttgg tataactaaa ttaaaagact
    11701 atcatattta tacaaatagg ggtagacatg aagaaaatta cggtgaagaa attaatctaa
    11761 ctcataagta tgcaattgta tttggatgtg agatggataa agaaatgata aatagagctc
    11821 caatgatatg tgaagttata gaaacatcaa agtgctatgt ggatgcatct atcgtcggca
    11881 tgattttaag ttactatata agaaatttag gatatgatgc tagaaatcat atggatgcta
    11941 attatttggt aatgcctgtt tttatagctc gtgatgctgg tttaggagat ataggaagaa
    12001 atgctatact tacgaataaa gattatggct ctagacttag attaggtgtt gttactacag
    12061 atattcctct tttagaagat gaatatgttg attttggact agaagatttt tgtaaggtct
    12121 gtaaaaaatg ctcttttaac tgcccttctc attcgctttc taatgatatt aaaattggtg
    12181 atgatggaaa atataattgg gtaattgaac atgagacatg ctatattaaa tggagatatt
    12241 taggtacaga ttgtggtatg tgtatatctg cttgcccatt tagccaaaat ctcgaaacta
    12301 taaagaatac tacttcattt aagggtaata atgagcttat tcaaaaagct ttagatgagt
    12361 atacttcaaa atttggtaaa agaatattta tacctggaaa tccatcttgg ttgaaataat
    12421 tttatttaat aaagaatctg tactagaatt tatcatagga caggttcttt attaaatata
    12481 taaattttta aatacttttt ctcgtttata acaattcagc aatgttttta gtctataatt
    12541 gacattataa aatattaaac taaaaggagt aactgtatgg aaaaaatatt agtagtagaa
    12601 gatgattcta tattaaataa aactctatca tataacctaa ttgaagatgg atatataatt
    12661 acttcaaaat ttacagctaa atctgcactg aagtctattt ttgaatgtga atttgattta
    12721 ataattttgg atattaattt accagataaa agtgggtttg aattatgtaa tgaaataaag
    12781 ggaaattaca atataccaat aattttttta actgctaatg atatggaatg tgatatgatt
    12841 aaaggctatg aacttggagc tttggattat ataacaaaac catttaatat caatatattt
    12901 aaacagaaag ttaaagcttt tttaaatcat cttacaataa aaacaaaaca agattactat
    12961 agggatggat atcttgaaat taacttttct gagttatctg ccaatataaa tggaaatcaa
    13021 attatattta caccattaga atatcgtact ttaaaactgc ttactgaaaa tcctaaaagt
    13081 attttaacaa ggaaagtact tttagaaaaa ctctgggata tagatgctaa ctttgtagat
    13141 gaacatactt taacatctgt tataagtagg attagaagca aaattgaaaa agacaatctt
    13201 aagtatatca aaacggtata tggtatggga tatatgtggt taggtgaaag aaatgaattt
    13261 taaaaaattt tcttttagtt ctatttattt aataattgct gttggtataa tttttacagc
    13321 tattttattt agtatctcaa tttatctaat aactgctgat ttaaaactaa ttgctctatt
    13381 attaatatat acaatagtgc tttgtggatt tatagcatta ataatatttt tacttcataa
    13441 aaaaatagtt atattttgtt ctaaaatatg tcacacttta gatagtatga tgaatagtga
    13501 agacaatatt gaaattgaat tagaagaaga aactatttta tcacgtatca atcacagatt
    13561 aattagaatg tatgaagtta ttcaagaaaa tcgcaatagt attgctatag agaaagctga
    13621 tttacaagaa ctagtttctg atatatctca tcaaattaaa actcctattg caaatttaaa
    13681 aatgattaat actactctac taaatcaaac atttaaaaca gaaattcaaa aggatttttt
    13741 aatggatatg gaaaaccaat tagataaatt agatttttta atgcaatcta tggtaaaaac
    13801 ctccagacta gagacaggta taatcacact atctaaaaag aaaaattcaa tttatgaaac
    13861 aattgctaca gcacttagtg gaattttgtt tgatgctgaa aaaaagaata ttgaagttac
    13921 agttgattgt gacccaaatt tatatataat tcatgacaag aaatggactt ctgaagctat
    13981 ttttaatata ttagataatg ctgtaaaata cacaaattct aatggtaaaa tacgtgtagc
    14041 tacagaatgt tgggttatgt atacaaaaat agatattatt gataatggaa aaggaatatc
    14101 agaaagtcat caagcagaaa tctttaaaag attttatcgt gaagaagatg tccatgacat
    14161 agaaggtatt ggaataggtc tctatctttc aagaaaaatt atatctcttc aaggtggcta
    14221 tattaaagtt acatcagata ttggaaaagg gtcgactttt tctattttct tacctaataa
    14281 ataaattttt aaatatttca tttgtaatga ttctgcaaca ttttggtttt atactgtatt
    14341 tacaagatgt taaggaggta ttattatgag tattttacaa gtaattaatt taaagaaata
    14401 ttatggacaa agttcaaaca ttacaaaagc tcttgatggt gtaactctat ctattgaaaa
    14461 aggcgaattt atttctattg taggtacatc tggtagtggc aaatccacat tattaaatat
    14521 gatgggagga ttagataatc ctacatctgg aaaggttatt ataaagggta aggaattatc
    14581 tactatgact gatgaacagc ttacaatctt tagacgcaga aatataggtt ttatatttca
    14641 aaattataat cttgttcctt tacttaatgt atatgaaaat attatcttac caataggatt
    14701 ggatggagag accatagata aggattttat aaatgaaatt ataaatatgc tttctcttga
    14761 agaaaaatta tatgatatgc caagtaatct ttctggtggt caacagcaac gtgttgctat
    14821 agctagagca cttgtaacaa aaccagctat tatactagct gatgaaccaa caggtaacct
    14881 tgatagtaga actagttcag atgtactgag tttacttaaa gtgacaagta aaaaattcaa
    14941 ccaaacaatt gtaatgatta cacacaataa tgaaattgca caactaactg atagaattat
    15001 tcgtattgaa gatggaaaaa ttgttaacta ggaggtgtag tatatgttta gaaataataa
    15061 tcgcacattt ataagaaaaa tagctttaaa tgatttaaaa attaataaac ttaaaacata
    15121 tctttcaggt atcattataa tgatttctac atgtttatta ttaacagtga ccttagtttc
    15181 atataatgcc tctgtagatt tagttaatgc atctccatat catgctatat ataaatctgt
    15241 agatgaaaaa gcaaaaaata tactatataa aaataaaaac tttagtggcg taggaactta
    15301 caaattaatt ggaagtaata aaaagacaga ttgtattatg tcgattgttt atgcagatga
    15361 tacaacaatt aaacttatga attttcaacc attgaaaggc aaactaccta caaataaaaa
    15421 tgaaattgct atttcagaaa aatatttaca ggaatttggt ttagataaag atattggaga
    15481 tagcattaaa ttaaattatt atgatgatat tacgaataaa gaagttcaat gtgattttat
    15541 tattgttgga tttctagaaa attattatca agataatgcc aagcaatact atacagtcgt
    15601 ttcaaatgat tattttaaga atatagcttc tacaccttta caaaataaaa gtaatacttt
    15661 tgacgagtca agacctgata ctgtagatgt attagttaaa ctatcagaag aaaatacaga
    15721 gaaagattca gcttcaatta agacacagtt aaagaaaatt ggtttatctt taggtattaa
    15781 gaaatataat atatacttaa atgataacta tattgaatca aatttaattg atggtgagca
    15841 gattattaca gttttagtag ttggaatagt tgttcttttt tctagtgttt ttgttatata
    15901 tagtattttt tatatttcag ttgttaattt agttcagatg tatgctaagt tgaaatcgtt
    15961 aggtatgact tctttccagt taaaaaagat tatttttcta caaggaaata ttttgtcaat
    16021 tatttttatt ccattagggg ttatagcttc ttgtataatt gcttacataa ttcaaccatt
    16081 agcatggcaa atgatagctg atttatttat aattttaatt ttatcactgg taatgttttt
    16141 aactgttaga atttctttat ttaaaccagc tagaattatt tctaaaatat ctgctattga
    16201 agccatgcaa tatacagaaa ctaaatttag aaaaaaagta aaaaatttta gttatataaa
    16261 tataaaaaat ctagcattaa agaatatcga gtcaaataga aagaaaaatt tgattgcatt
    16321 aatatcgcta agtattagtg gagttttatt tatttcaatc gctaatcttg ctaattcaat
    16381 agatttcaaa aaacaactat ctcaacaatt tgtctataac gaagattata taattagcat
    16441 taagagtgat aacttatatg agcatattac agaaatccaa caaaataatc cactaacaga
    16501 ttctcttaag aatgaaatta aatctattca tggagtaaaa aaattaattg aatccaaatt
    16561 aattaaaagt aatattatag aaccttacat caaagataga gacgaaaaac aatttattac
    16621 tctaattaaa ggtattacgc ctgaactttc aaaatcactt gaagaatata ttgtcagtgg
    16681 aaaaatagac tatacacatt tagattcaga tagtttaatt ataaataaat atagaacaaa
    16741 atattatgga ttaaatttaa aagttggaga tacagttaca tttaatatct ttagtggaaa
    16801 tgatattatt aaaaagaaaa tgaaaattat aggaatcatt gacaattcca atacagaagg
    16861 tatgtttttt gcttcagaca aaactttaga atctctaaca ccatataata caaatttaga
    16921 tttttctatt ttaatagata aaaagtattc taaagaagtt gaagaaaagt tgttaagtat
    16981 aattcagaaa aattcaaatt taatgcttta ttcatatgaa gatgattata gaatgattac
    17041 tagagcattt caatatataa ttatagcttc atacattttt gttggtttaa tttcttgctt
    17101 tggtatacta aatatgacca ataccctaat aaacagcgtt ttaattagaa aaaaagagtt
    17161 tgccttactt caagccgttg gaatgacaag aaagcaactg cgaaatatgc tttatagaga
    17221 aggtctaaac ataagtatca aagctatatg tacttcaagt atactaggtt attttggttc
    17281 aaatctactt tgcactttta taaaagatgt aattagatta gactttatta attttaaatt
    17341 ttctatattt actattttaa ttttttcatt cgtattaatt ggtatacaag ttttagtgac
    17401 tgaattactt gtaagaaata tagaaaaaaa atcacttaca gaacgcttac gttctcagta
    17461 agaatgtata taaaaaatag ccatttttta tacaagtttt aacataattt tttaaaagct
    17521 aaaaggatag aaaattttga ctttacataa ttttctatcc ctatacttgt ttttatttta
    17581 tacagataca cttccttata tctccgagca acatcaccag agacataaac aagcatattc
    17641 cttattttct aaatatgtca attgcatgac ttgtaacccc tactaaatct tcacgttcac
    17701 aagtagcaag gtgatatttt aagtataatg caaatgcatc atcatccata gagtctactg
    17761 cttcacgcat atacaaagcc aaaccatctg atgcgacata atgcagtcta gttacattaa
    17821 atgcagacat caaatcatca atgttttctt tacgtacaag ctcaaacaaa tcctttggtt
    17881 cagacttagc agcaaatgtc tgtggatcaa tcaaaccttt ttcaatatat tcagatacat
    17941 taatatttcc tctatggaac ccctcgtcaa tgagacagcc atcagatata acatatgcag
    18001 caaaaaccac accaccaggt tttgttacac gaattgcctc atgtaaagct tgttgtttat
    18061 cttctttgtt ataaagatga tatagtggtc ctaacagtaa cgtaatatca tatttattat
    18121 ctgggaaaac agataaatcc atagcattac cctgagtaat gcttatattt tcatttgatt
    18181 gagtattttt atggaaaacc tctatattat gttcgactaa ttccactgcg tcaacatcat
    18241 atccctgacg tgccagtgtg tgagaataac gaccagttgc agcgccaatt tcaagcacac
    18301 aatcacctga ttttatgtac ttatcaatgt aatgcatagt agtgagaaat tccaccattc
    18361 catgttttaa tgcaagtcga ctatcttcat cataagtatt ataaaagtca attaagtatt
    18421 gttttgtttc cataatttca cctcttctat attagttaat aaacatcaaa tagacaaatt
    18481 ccaatctggt ttttcttgtc ttataaaagc tgttaatata tttttcaaca ttttttcagc
    18541 actatatcta tctaatgtta gtttttttgt tgctgttaag acagctatgc catgagtata
    18601 aagaaataaa tctaaaaata ttacttttgc acattccaac tctattccaa tgctttccga
    18661 aaaaagtctt gccttttttt cattgtcaat ttctttataa aaatcattcg cctctttcat
    18721 catcaaatct aaatcattta taaataacaa cttaaataaa tacgtttctt cttgagcaaa
    18781 ttcaatgtat gaaagcggaa gcagtaaata agggcttaca cttttagaat tacgataatt
    18841 aacaacatac tgattataat attcatatgc aaaagcaaga aattcatttt ttaattcatt
    18901 catgttttcg taacaagtaa aaattggtcg agtggaacac tgtaatttac ttgcaatact
    18961 cctcgcattt acagcttcaa atcccacttc tcttgtaata tccaagactg tattcaaaat
    19021 catttctttt gttatcttta ctttaggtgg catatatgtt cacctctcca ttaaattttt
    19081 ataaaacaca tatgttatat aactatagta acatatcaag aaattatgtc aagaaaaagc
    19141 tttgcatttt tttgcaattc ctaaaactta taaataaaac atgagttgct gttatctatt
    19201 aatagataac agcaactcag attttccttt aaatactctt ctttttgtct aatatttcat
    19261 atacacaatc ttctattgaa ttaatatctt tttcttttct ttttttagaa tcaattaaaa
    19321 tgaaatacag tataaaacct acagcaagtc cccatgttcc gcctttagca gcaattacac
    19381 ctcccataag tccaatcaat cccttctcaa cacctgtatt acatagctcc attgatagct
    19441 ttgtacataa atatccttga actaaaagtg ttactgacaa tgctaatggt ataagaggtg
    19501 tagcaatctg cgcaattgga taaaagcaga taaaaattgc tgaaacccat actaatgtac
    19561 ccataccact aaaaacagac tgcatggctt cctttccaat cttgtacctt tgagcaacac
    19621 ttcctgtaag tgtcgcagct aatggaccac acattggtat atatggagaa aagattgcca
    19681 taaaaatatt tcttatccca cttataacat tagacctatt tgaattgaaa tctatatatt
    19741 catcttttct attttcactt tcagaaagta ctaaattttc acctgttata aaatcaccaa
    19801 atgcaattat gtatatcata aaagccattg gtatcccttg tataaataac attacacttg
    19861 gaaaacctat tccaaaagga gatactgtat ttatcagatt tttaaaatct actatgtaaa
    19921 ctaaattgtc aaaactaaat ctaggaattt ctatttctct actaaatata cctactatta
    19981 aactcactaa aatagctgat actacaccat attctcctaa atgaaataaa aatttattct
    20041 taacttttag agtatcaaat ctttcagaaa acattacaaa acaagcaacc aaaattccta
    20101 ctgttataga tataggataa gaatcaaatc tccctttagg attaaactct gatattatag
    20161 tcgatatacc gacacccatt agtattccac ctttaataga atttggtatc ttactaacta
    20221 actttccagc tacaccagtt atacccatta aaataaatat tattcctaaa tctatttgta
    20281 aagctgttaa tgcttgtatt ctttcaatgc ccatgctgaa ctttaacaaa tatgcagttg
    20341 taagagttat agaagctgta atccagccag gtacaactgg gtctcccata aaaacatgca
    20401 aacagtataa tattgagtta atgatagcca tactccatgc cacttcatag ggtaatccca
    20461 atatttgtgt actaaggcca attgtgccta aacttgtcat acttgatatt ataccttgaa
    20521 tagcttctgg tttctcaaat ctgtaatgta taaatggaat tcttatctta aacattccaa
    20581 attttatatg aggttgttcc cttctagcga gtctttccat aacttcactc cacctttcaa
    20641 taactcttgt aagtttacaa ctttataatt gtttataaat tatcaatgtc attaaaatta
    20701 gtatataaca tgcaaattat ataaacaata aattaaatct ataaaattga tagattttgt
    20761 gcatatatag aaagaccact tcatttttag ttacttaaat cacttaatat tagttattta
    20821 aatcacttga taaaggtttt ttataaaatt caatagttct attccatgat tcaaactgtc
    20881 cttttgaatt tccttctaca gttccacctg aagaaaaaat ccctccactc atactcatac
    20941 ataaagtctc ctttagaggc ataatatatg gaattggtaa cggatgaccc atattattgt
    21001 atgttaataa ttctacgtta tatggataat tattttcttc aaagatttct aatgcctcta
    21061 aacaagcttc ataactattc catatgttat cttcttttcc agcaatcata agtatatctg
    21121 ctttggaatt ttctattttt attctagcct cttttctatt ctctgctctt ttaagacttt
    21181 tcttataagt actattaaat ccaaatggaa tatcttttga tatatttttt ttctgttctt
    21241 caaagaatat atcattgtct actttgatat atggaaatgg ctctccttta tatgaccatg
    21301 atgaagtatc atttccactc atcaatccat taagagcttg gaaacaataa atgtgaggtt
    21361 gtgatactac aaccttttta atttgttcat atcttgaagc aagtaaaaag gccaattctc
    21421 caccctttga tgtcccatgt acaaatattt ctttagtact ggtaatttca ttttcactaa
    21481 tccactcaaa tactttttca aaatattcta atggaacctc ttctaattta tctggtaacc
    21541 cttctaaagc aaagtatgca actgttagta cattgaatcc tctagatgca agtggagctg
    21601 ctaaaaggtc tagagcgtct aaatttccat cagaaccacc tagcattaaa attgttttat
    21661 tattagaatt ttgtttataa aataattttc ctataaactc atcagatatg tattttgtgg
    21721 taatatcttc tgatttaaat attctcttta attcaacttc ttttctttca atagaagttt
    21781 caaatatcat attcataatt attggtttat caatagatat attttctgca aaatttttac
    21841 cttcagtttt agatttttcc agcgaataaa ttaaccccat acaattatca gccttataag
    21901 taccttctat aggttcaact aaatctaaat ctacttctcc tttttcattt gaacaaaaca
    21961 ctccataaga tgaaaattct tctcccttgc accatggaaa ttccattttc acacttattt
    22021 taagtttagt atttggaatt aagtccgaaa ccataatctt aagtctttca tccacaaatg
    22081 attctacatt gtatacattt actttcataa tctatttctc cttataataa ttatttatgt
    22141 tttatataaa acagctttat ctaattcaac ataaataaat ttttaaatta agacaccata
    22201 ttgactattt cattttatca acatattcca tctttgtcaa tatattgtct tttttagtaa
    22261 tttaaaatta tgtagtctat atgaaatcca gttgattttt ggctaattaa agataggaat
    22321 gctattaggt ttaaaatata tctattcaaa ataaaaaacc actcatttta agaatggttt
    22381 ttaatataaa ctatttgtta ttaataagga tattttttta tttaaattta tataatcgaa
    22441 catctaatat ttaatgttta ataaaattat gcatttgcaa aagtatatat ggcattaact
    22501 cttgctacat ataaattctc atcactacat ccaatatatc tagcatattt ttcaatcttt
    22561 tcttttgcat tttcaacatc attttcatcg ctctccatta actcatttat ataaatatcc
    22621 attaatgacg ctttatattc tcttatatca tagcctaaaa attcagtcaa tctctcaatt
    22681 tccttactaa aatctccatc ttcttttacc aaaaattcgt atacatcttc cctatatgga
    22741 tttaaagtta ttatttgttt tactactttg cattcgtcag ccttcccaat aaaaccatct
    22801 ttataattat taaataaggc attagatttt tttatagatt cttcatcaat ataagaatgt
    22861 accgcagtta tacgattttc tataagggca tctacaacag cataatgaat tttaaaacaa
    22921 tcattgtata aataattgct cattttcttt attgtcgatt ctatttctaa gaagctcgcg
    22981 tggccatttt ttttattttt atttggtata ataaaagttt tattcaaatt attaaaaagt
    23041 ctcttaaaat ctaaatattt ttcacaataa acacttttaa aggtatcgat atctatagtt
    23101 ataattccaa aacttactat agtctcaatt cctttcttaa aagactcttc tatatatttt
    23161 tctcctaaac ttaaacctct atcagatatt tgctttagat tttgaaaact atttaaacaa
    23221 tctctttcaa agtttttaga tatttctaaa gcatataatt taaagatttt ccttatctta
    23281 ttataattat tttttgtatc atcaaatctg ataatagctc catttacatc aaaagtaatc
    23341 attgagtttt aacctcccca ttagtttcat caataaaata aatttaatat aaactttata
    23401 atcataatat taaacttatt tatactataa ttattaattt gatgataaaa gctattttcc
    23461 ttctaaataa aaaatttgtc taaagtttct aaaaaattta gacaaatctt aggttattac
    23521 tctttaaatt atttttaaat tattccaaat acgccaaata atattggtat aaatatagct
    23581 ggtaacaaat tggctacttt tatattcgtt aatttaagta catttagacc aagtcctata
    23641 attaataaac ttccagctgc tgtcatttct gtgactacag gatcacttaa aaatccattt
    23701 aaaaatgatg ctcccacaca tataatacct tcatacaaaa atacagatat tgcagaaaac
    23761 attacaccta tacctaaaga agcagtaaat ataattgaag ctattccatc tataacagat
    23821 tttacaaata aagtatcatg acttcctgta agaccacttt ctaatgaacc aactactgcc
    23881 atggctccta tacagaataa taaactagat gatataaaac cctctgctat agaatctttt
    23941 ttatttcctt tagaaaattt actttgtaaa aaagcaccca acttatttac ccatttgtca
    24001 atatctatta attctcctat cagagcacct acagctacgg atattattgt cactaatgtg
    24061 ttttttcctt ctagtgctcc tgatatacca atgtacaata cacataaagc aattccattc
    24121 attatagtat cgcttactct ttgaggtaat cctcctttta ttataagacc tactatacat
    24181 ccacctgcaa ttgctagact atttgctatt actccaaaca ttttttctcc cctcgattag
    24241 ctaattgaaa tttatcctat tattaaaacc taaacatcta tactttgtat tggatatttt
    24301 aaatattcca aaaattcttc aaaacctttt ctagatatat ttacagtttt agtatttatg
    24361 ttaggatgaa aatttaagta atcttcttta attacatctt tatctatgta aagctcaact
    24421 tttctttctg tatcatttat taatgaaaaa ggatttacac ttccaggaag aagtttaagt
    24481 acattgtata gtctttcagg tgaagcaaac gataatctag aacttcctat cttatcttta
    24541 agtgagttta aatcaacttg tttttctcct ttaactacaa taagataata cttatttcct
    24601 ttggcatttc ttaaaaataa atttttacat tgacacccct ttgttattcc atctaaaatg
    24661 actaattgct ctgctgtata tacagcttca tgctctacta catcatattc aacatttaat
    24721 ttatccaaaa tatcatatat tttagtttca ttcatgctag attcattttc atcttgttct
    24781 tttttattat ttaaatcact catacttttc tccttaaaca cttcatcata atatcattgt
    24841 gaggtattat tctactatag ctattgctct tactggagct ccatcagcat cattatactt
    24901 aaatggtgct gctataaata gaaatttttc tggaacattt tctaaatttg taagattttc
    24961 tatgattatt tttccttttt caaataaaat atgatgcact tcaaatactg atgtgtcata
    25021 tctatccact gatagcatat ctattcctat gccttttata ttagtattag ctatatagtt
    25081 tgcagcttct tttgttaatg taggataacc tacatagtac tgctttttat cccaaaattt
    25141 tgaccaacct gatttaaata ttataaaatc actatttttt atttcatctt catatttttt
    25201 tagatattct aattctatat tctcatttcc cttttcaagt tccaatacat aagctttccc
    25261 aacaaaattt tctatatcca acttatctag ggtctcacct ttagtataca tatgtcttgg
    25321 tgaatccata tgagttccat tgtgagaaaa tacactaatt aatgtttctt gataaccatt
    25381 ttcttcaata atagctactt tcttgatatc tggtctatta ggctctgcat atacaggcat
    25441 gtcattatgt gtcacatgag ttaaatcaaa aaccttcatc tttatatacc ccctatgttt
    25501 ttattttcta ttatatacct aaattcattt tatttctatc agattttatt ccattatata
    25561 ccatactact atatattttt tataaacctc aagggattta ccgaaaaatc ttggaaagaa
    25621 ttatcagtaa atataacatc ttcacccaaa aaacgtttat accttccttc ttctttcttt
    25681 aaagtaattc tctgtttttg tgaatgatta ttaaaaacca ttatcttaag aggaggtttt
    25741 tttctattag tctgcactct ttttaacatg tattttatgt gcatatcagc ttcaggaaat
    25801 gaatatccac aaaatattaa aaggtcagta tctcttaaag ttttttctgt ttcattccaa
    25861 acattactta aaaatatgtt tgacatattc ttaaaatatg ttggtggcac tataataggt
    25921 tctgttaact caccacactc taaacatttt gtctctgaac tattttcaat aagcttcatg
    25981 acaccacctt catgtggtgt aagagttaca ctattacaaa tggggcaata aagccaattc
    26041 aatgacccat gtatcttata taatttgatt aatggttctt ttggttttct ccaatttaac
    26101 tcctctttaa aatttgtaaa ctccacacca taatcaagca taattggcaa atcattctta
    26161 tctcttaatc cagtaactgt attgtctata tgtatatcat aatttgcact aataaaagta
    26221 gtatcaagaa gcaaatcatt ttccaaaaga ttttcaacta aaagtttatg atatttatta
    26281 tctgttctag gtgtattatg aattgcttca gccattagca gtattaaata ttgtcttaaa
    26341 aaacgtatac tatcacttct gttatttaga ttttctagtc caaaatttct aaatgcttct
    26401 tttctttgtt ctgctaagtc taaaagacct aaaacttctt caaaggtagg aaaatttgca
    26461 ttatctatat tatcttttac tatatcaata ttgaacatct gtttaaagaa aatatacaat
    26521 tctctattca ttttggtatt ataatttgtg ggatttagtt ttttaaaata ttcgctaaaa
    26581 agttcatttt gaataggtag attctctgct gctgaagctc ctgctcctaa aaatattgct
    26641 attttcatat agttcctcct aatataaata ttactcctat ttttatatcc attaaatatc
    26701 catatcattt attttatgat acaacaataa agctgtcttt tactagaaaa aatcctatta
    26761 caagacagcc ttatattata ttaaatcttt aataattcgt aaatagaaag agcatatatt
    26821 tgagtagctt ttataatatc ctctactatt aagtattcat tagcttggtg ttctgtttct
    26881 ggttttcctg gaaaaatagc tccaaatgca acacaattat ctaaagctct tgcgtatgtt
    26941 gctcctccag atgaaagtgg tgttccatca agaccagttt cttcttcata tacttttcta
    27001 agtgtcttaa caagaagagt atcttctgga acatagattg aatccaagaa atcatattct
    27061 tcataattta aattgtattt atctgtcatt ttctttaact cttttacaaa atcatccttt
    27121 ttgtatgtta ctggaatcct tacatctatt cctgcaaatt ctttttcgtt atcaatagtt
    27181 actctaccta tatttactgt tagtttacct gatacatcat ccttgcaatt aggaattata
    27241 ttgtttccat tagcatcttc accaataact tctgctaaaa acttaattat attagaatct
    27301 atacctatat tattaagagc tatacaaagt ctagccactg catttatacc agtatcactt
    27361 gctgctgaat ggacactttt tccaattata cagattttat taccttcaac agtatattca
    27421 aaatttaatt tatcaagttc tttttttaat ttatcagagt attttccaat atagattgct
    27481 ttacctggaa ctgcatttaa agcctttcca actgacaact ctatatcact tttgctatca
    27541 caagtcaaat gaacttgtaa aagacctttc tctgcatttg ttattgggaa tctagaatct
    27601 ggagtaaatc catagtttgg tatttcttca ttattttctt tatatttatt tatacatctc
    27661 caaagatttt cttcatcagc cccaaaaatg aatcttatcc tcttattaaa gtctacattt
    27721 aaatccataa gagctttcac tgcataaatt gctgatattg taggtccttt atcatcttgt
    27781 gttcctcttc catacaattt accatcttct aaaacagctt caaatggagg gtaattccag
    27841 ctttctaaat caccttctgg aaccacatca acgtgaccaa gtatacctat cattttttca
    27901 ccttgtccta tttctgcata tccataatat ccatctttgt atactgtctt aaatcctaaa
    27961 gatttacata agtctaatat acctcttaaa gctttatcta cattttcacc aaatgggcaa
    28021 ttttcagttg cttcagatat aacactaggt atttttacac tttcttgtat tgaagaaatc
    28081 atttcatctt gtagagaatt tactttttct ttaatttgct ctttcatatt atcacccttc
    28141 aattttcatc ataatatact aataaatatt ttgacctttt aaaaaaaaaa tatgcttatt
    28201 ttttcagttt ttttataaat tcaatcgctt ttaaagtccc catttttgaa tggtcaaatg
    28261 taagtccacc ttggaaataa acattataag gaggtcttat tggagcatct gcacttaatt
    28321 ctatagaaga accttgtata aatgctcctg ctgccattat gacttcactt tcgtatccag
    28381 gcatgtccca aggaacaggt tttacataag aatcgactgg tgcagcttct tgtatacctt
    28441 cacaaaaact tattacttca tcagcattat taagtctaat acattgaata atatcacttc
    28501 ttaagtcatc atattttggt aatacatcat atcctaattt ttcaaaagct cttgagcaaa
    28561 agatagctcc cattacagcc tgagatacta tataaggcgc caagaaaaaa ccctgaagta
    28621 catttctagt tgttccaaaa gtaagaccac attcttttcc tattccagga gaagtcattc
    28681 tataagatat aagctcaatc aaatcttttc taccagctat atatccacct gtcaatgcaa
    28741 gcccaccacc aggatttttt attaaagagc cagccataac atctgctcca acatcagtag
    28801 gctctttggt atctaaaaac tcaccataac aattatcaac cattactata gcttctggtt
    28861 taacagactt tattacttct atagcttctt ttatatcact aattgaaagt gattttctcc
    28921 aagaatatcc ttttgacctt tgtatcataa cgagtttagt tctatcattt attttgcttt
    28981 taattccttc taaatctaag tttccatcct ctaaaaaatc tacatcatca tatgtaacac
    29041 catactcttt caatgaacct ttttcttctc ttatgcctat aactccctct aaagtatcat
    29101 atggtctacc agtaacagat aaaatttcat ctcctggtct aactatacct tgtatacata
    29161 aagtaagtgc atgtgtacca tttacaatta ttggtcttac aagagcatct tctgtattaa
    29221 atactttaga ataaatttcc tctatttttt cacgaccaat atcattatat ccatatcctg
    29281 tagtccagtt aaagtgcata tcacttagtt tagattcttg catagctttt aaaactttat
    29341 attgattata ttctcttatt tcttttattt cttcaaactt atcttttatt tcttccatta
    29401 tttcttgtga tagtttaaaa gtatcatcat ctattccata gtagtctttt aataattctt
    29461 ttgtctcatt aagcatttta tcacctgtct ctttattatt ttatttaaac atgtaaagga
    29521 gactatttta ctaaaacaaa taaattatag tttataagtt agtataagtc tcctctcaat
    29581 catcttaaat taaattaatt atctatctgt tgttattatt attgttgttt tggttttgat
    29641 ttgttagatt aatatacttt ccaggttgta tagttgatac agcatgttta taaatcatgt
    29701 tttgttgtct attatcccct tctattaata ttatataact atcaaacccc tttacaagcc
    29761 ctttaacttg cactccatta actaaatata tagtaacagg tatcctttct ttccttgcat
    29821 tatttaaaaa caaatcttgt aaatttaaaa ctgtattttt cattagattt gtaccctccc
    29881 aagattaaat tgaacttcta aaatattcct accttatatt ctatataagt tatgacaaat
    29941 tttcaatatt aagttgtata cttaaaaatt tatatattat tttatagaat ctttaatata
    30001 taagattatt tcatttttta attcgtctat attttcatat tggtctaaat caaaccattt
    30061 tgctgtttta tatcttttaa accatgttat ctgacgtttt gcataccttc tagaatctct
    30121 tttaattatt tcaatagctt cttcgtatgt atattctcca tccagatact ttaatatctc
    30181 tttataacct ataccttgca ttgatatcat atctttttta aatcccatac ttaaaagttt
    30241 ttttgcctct tcaaccaatc catttttaat cataatatca actctcatat ttattctttg
    30301 atacaaatgt tctctatctc tatttagaac tattattatt ggttgatatt cttcattaaa
    30361 ttttaaatca cttgaaaaat cattcatttt cttaccactt agacaaactt caagagctct
    30421 tatgaccctt ttagtattgt ttttatggat tctattagca gattcttcat caagttcttt
    30481 taacttatta tgcatgtaat ctattccctt ttcagcaagc tgtttttgaa gttcttctct
    30541 taattcatta ttggcatcag attgtgcaaa atccatatta tatattaaag agtttaaata
    30601 aagtcctgtg cctccagtta ctaaaacaca tttttccttt tcatttattt catgtatata
    30661 tttttttgct ctttgttgaa actctgaaac tgaaaatgga tagtcaggct taacttcatc
    30721 tataaggtaa tgcttcactc cttgcatctc ttcctctgta acttttgcac ttccaatatc
    30781 catatattca tatatttgca tagaatcagc tgaaattatc tctgcattca tatcttttgc
    30841 taattttatt gacaaatctg tttttccaac agcagttgga cctgtaagta ttataagtgg
    30901 tatttttttc ataacattcc tttccatata ttttaaatat ccaaatattt tacataattc
    30961 ttttaaacat tttttctatt tctgtcttag atatttcgac cattataggt cttccatgag
    31021 gacatgtaaa tggattctca cacttttcta gctgttccaa taaacttttt atttcaatat
    31081 cgtatatttt atcatttgct tttatagcag acctacatgc catagatgca aatctctctc
    31141 cttttaaatc ataattactt gtaatttctt ctatattatc aattatttga agtataaatt
    31201 tctcagtttc aggtactcca aatatagtag gaacacatct taccattata tgattattgc
    31261 caaaaatttc tagctcaaaa ccaaatttca taaataactc caagttattt tcaatttgaa
    31321 gcatatctat atttgatact tcaataacca ctgggtctaa aagtatttgc atatttatat
    31381 cttgtctata gaacttctcc atatatcttt catatagtat tctttcatgt gcagcatgtt
    31441 ggtccaacaa atacatagaa tcgtctttgc tcaaaattat ataagtatta aatacaactc
    31501 caattacaaa atatccgtat aaagaaaact tgcgttttga actacacaag tattcttctt
    31561 cactgtcctt aatactatct cctaagtaat aatttccttc atttttaatt ccatcaactt
    31621 gaaactcttc ttgtatatta tcatttgcac tatcttcact tagataatta atgtttttta
    31681 catcatcttc tacacttgca tttaggactt cacttactga ttgaaattca tttattggtt
    31741 tttcacttga taaagtaaca acttcaatga cttcatcctt acctttagta atattactat
    31801 ttttaggagt agattctaat aaatcattat ttcttaattt ataatctgta cttttttctc
    31861 tactgttaat agcgattcta ggttgtgttt ttttatcact ataagtagca tattttccaa
    31921 taagatttga gtgtattaat ttaaccttta aaaaatctct aagttctata tacacttctt
    31981 gttctttttc aaatttaatt tcaagtttat tggggtgtat atttacatct atacatgatg
    32041 ggtctacttc tatatttaag aagcacactg catgtttacc tattggaatt atagacttat
    32101 aactttctgt tattgcatct atgattattt tactttttac aaatctttta tttatataga
    32161 tatgttgtaa gtttttattt gaacggtata tattgttatt acctatatat ccattcattt
    32221 taaagtgatt gcacttaaac tctacatcta ttatattttc cgttatttct tttccatata
    32281 tacttctaat agtgtttaca agttttccat cccctggagt atttagcatc tgtttattgt
    32341 tatttgtata tttaaattga atgtttggat tacctattgc aagtttattt atcaaatcac
    32401 ttatgtttat agtttctgca tgagtagatt ttaaaaattt ctgtcttgct ggtgtattaa
    32461 agaaaatatc ttttataatg atggtagttc cattagtaga acctattggt tctttcgata
    32521 ttatttttcc accttcaaca tatattttag ttcctattat ttcatcttta gttttagtcg
    32581 tcatttctaa ttttgataca gctgaaatag atgccaatgc ttctcctcta aaaccaagag
    32641 agtataaatc atacaaatca tcaatttttt taattttact agtagcatgt ctcaaaaatg
    32701 atttttcaac ttcacttgaa ggtattccta ttccattatc tgtaatctta attagacttt
    32761 ttcctccatc aattatatct atggaaattt tatttgcacc tgcatcaatg gagttttcaa
    32821 taagttcttt tactacagaa gaaggtcttt ctacaacttc acctgctgct atcttattta
    32881 tagtcaaatc atctaggatg ttaattatat ttttcatttt tacacctcta agattttatt
    32941 tcttttgctt ttctttgaag attataaaga gagtttatag catctaatgg agtcatattt
    33001 aaaatatcca gatttaaaat ttcttctgat agtatatctc tatttacact atcaaaagag
    33061 atttgagtta aggctacttc ttttacagaa tcttcttgat taattttctc tttatcatca
    33121 ttttgcttca ttaaagcaac ttcatcattt aatgctttaa atttagaatt taatttatca
    33181 taatcctttt ttatatgttt gtagtctttt actataagtt catgttctat ttttagagat
    33241 tcatatttat tcttaaaatt actttgattt accttaacta attcttcgtc caaattacta
    33301 ttaattatat tattgttttc tttatctcca tttattgcaa cactgttgta aacatgattt
    33361 ttttccaagt ctttaagtat atattttgct ctttctatga cttcgtctgg taatttagct
    33421 aatttagcaa catatattcc ataactcttg tctgctccct gaggaattat ttttcttaaa
    33481 aatattattc cttccccatc ttctttgact gctattgaat aatttttaac ctctttaaac
    33541 tcttcttcta aatcagtaag ttcatgataa tgtgttgcaa ataatgtctt acatctaata
    33601 tttttttgaa tatattccac tattgaccat gctaaactta taccatcata ggtactagtt
    33661 ccacgaccta tttcatctaa tataactaaa cttctctctg ttgcattttt taatataagg
    33721 gatacttcgt tcatctctac cataaaagta gattgacctt gagataaatc gtcactagct
    33781 ccaactcttg taaatattct atctaatatt ggaatatcag cagactctgc tggtacaaat
    33841 gagcctatat gtgccataag agctattata gcagtttgcc tcatatatgt tgatttacct
    33901 gacatattag gaccagttat tatgttaata atgttttctc cacgatttaa ataagtatca
    33961 tttggaacga aattttcctc tcctactata ttttcgacaa caggatgtct accatttctt
    34021 atatcaagtt tattattttc atttattgct ggttttacgt agttatttat atgtgcaact
    34081 gttgcaaggg acacaaaaac atctatatta gctatagtct tagccacttt ttgtattcta
    34141 tctatgtttt tatatattgt atctcttatc tctacaaata tctcgtattc taaagattta
    34201 atcttttcct ctgcatgtag tatcttttct tctatttcct ttaattctgg agttatatat
    34261 ctttctgcat tactaagtgt ttgctttctt atatatgtct catctagctt tgcctgttta
    34321 aagttggctt ttgttatttc tatataatac ccaaaaactt tattaaatcc tatttttaat
    34381 gatttaactc ctgttttttc tctttccctg ttttctattt cctttacaag aaaggctcca
    34441 ttcttagaaa tctctcttag ttccttaagt tcatcactaa aatctgattt aattatgttt
    34501 ccatctttta tggttatcgt aggttcttct agaatagctt catctattaa attgtatata
    34561 tcatctaatt tatccatttc tgaaacatac tcttttagga tttttgcatt tgataaattt
    34621 atagtatctt ttaaattagg taacttttct atcgaatttt ttaagtgaat taactctttt
    34681 ggtgttactc tctcaaatgc tatctttcca catattcttt ctatatcgta tatattttta
    34741 agtatatcat ttaggtcttc tcttaatata aagtcatctt ttatttcttc tattacatct
    34801 aatctatttt caattttaga tttatttatc aaaggttctt ctacatattt tcttaaaagt
    34861 ctacctccca ttgctgtaga agttttgtca agtacatgta ataatgaacc ttttttctta
    34921 ttccctctta tagtttgagt aagttctaaa ttagttctag taaacatatc tagaaccata
    34981 tattctgatg aattgtatat atttatatta ttaatgttag atgttatttg tttttgagta
    35041 ttgtatatat aattcagaag aattgataag cttgacttta ttagaccttt atcatcaaac
    35101 tttagttttt gtagataaac atctggaaaa tattctttta atatatttat atccaaatag
    35161 ttatcactaa aactttcatt tatgtatata ttacttacag tagctatatc tctaagcttt
    35221 tctataaagt ctaaatcatt tataattatt tcagttggat ggatttttgc aatttcttca
    35281 attaccttat cttcatttaa acatgttgca ttagtttctc ctgtacttat atcaacataa
    35341 gttagaccta tattagtacc atccttatac aaagataata aataattatt ctttttattt
    35401 tcaagtaaat ttccatctaa aactgtacca ggagtgatga cccttataac ctctcttcta
    35461 acaattcctt ttgctgtaga tgggtcttcc atttgttcac ctattgctac tttatatcca
    35521 ttttcaacta attttgatat atatgaattg gctgagtgga aaggaacacc acacatagga
    35581 gcacgttctt ctaaaccaca agcttttcct gtcaatgcta tttcaagagc ttttgaagct
    35641 actaatgcat cttcaaaaaa catttcataa aaatctccaa gtctaaaaaa cagtatacag
    35701 tctttatatc tattttttac ttcaagatac tgtttcatca taggagttaa tttattcata
    35761 tctatttgca ttatcaaacc tccttctttt ctaattaaat attatatcat agtagatgat
    35821 tattattaac acaatatata aaattttgac atataactaa aaacaatcca aaatgtatac
    35881 tcacattttg gattgctaag tttaatgctt attaaataaa aatatttttt tttacaataa
    35941 agatattatt tcttttttaa gtttaatgat attttcaagg ttatcttcat ttaactttct
    36001 actatctata acaaattctt tctttactat tgatggtttt tttgaaataa cataaattct
    36061 gtttgatagc attatagctt cgtcaatatc atgagttata agaagtattg ttgaatttac
    36121 ttttttctta acatctaaaa gccatttttg catggatgtt ttagttaatg aatcaagtgc
    36181 cccaaaaggc tcatctaaaa gcattatgtc attagaattt ataaaagttc tcaagaagtt
    36241 agctctctgt ctcattcctc cagaaagttc tgaaggatat ttatcttcat atccgcttaa
    36301 tccaaacacc tcaaaataag gttttaccat tgacctagct ttactctttt tttctttttt
    36361 taaaattagt ggtagtgaca cattatctat tatagtttta tatggcaaga gtaaatcttt
    36421 ttgatacata taactatact taccatttat attcactttg ccactatcat aatctgtaag
    36481 tttagttata atattaaaaa tagtactttt tccacatcca cttggcccta atatagaaac
    36541 aaactcacct tcataaacat caatacttat atcttttaaa acttcaatat ctttataagt
    36601 ttttgataca ttttctatag atacttttac ttttttattg tggtaaaaat tcatttgtgt
    36661 aagcatcact tgccttcata tccttatcta ttaatttata ttcttttaag aatgatgtat
    36721 agttgttcca tacactatct ttcatttctc cccatcgtgg tgcatcatct ttgtacttgc
    36781 ttgctaaata ttcttgactc tttaaagcta gtttttcatc tacttcaggt gcatgtttta
    36841 ctaaaatttt tgctgattct tctggatttt ttattgcata ttcataacct tttgttgtag
    36901 cttttaagaa ttttttagca agctctggat tatttttaag cacagtttca ttagaaatta
    36961 taagtggtgt ataataatcc aatctctcat ctaaatcttt tactggtata aagtttaagt
    37021 catatccaat taaatcagct ttaactgcat cccaaccttc aaatatccat gcaaaatcta
    37081 cagttttcat agctgcaaag aaatcatctt gaccagtatt aactatcttt aacttattaa
    37141 aatcagctcc atttttcttc ataactgctt taaaaacagc ttcttctgat ggagagcccc
    37201 aaccaccata agtttttcct tcaaaatctt tagctgttgt tatattcttt tcttttggtg
    37261 atgcaaaccc agaagtatta tgttgtataa cagttgctac agcttttatt ggaagtggat
    37321 cttcactagt ctttgcataa gtaacttgtt cttgatagct tataccaaag tcagcttttc
    37381 ctgttgctac taaagtttct gctccacttt caggtggttg tactatttca acatccaaac
    37441 cttcttcttt atagtaaccc ttatcaagtg ctacaaataa tccagtatga tttgtatttg
    37501 gtgtccaatc aagcaccata gttacttttt tagaagaagt atctttatca ttgtttttgt
    37561 ctttattgtt atttgaagaa catccagtta ttgttgccaa tgtaaaaaca cttactaaac
    37621 ctaatattcc taacttttta aaattcataa ttgcctccct caaataccct taatctatta
    37681 atctatgtct tataacaact ttttttacag cctgtacaat tcctacaaac attaaactaa
    37741 atataactac taatatagta gatgcaaata ctttatcaag tgcatatgca ctttttgacc
    37801 taagcatata aacaccaagt cctttcgttc cacctagcca ttctgcaaca gttgctgcca
    37861 ttacagcata cgttgcagat attttaagtc cagaaaaaaa tttatccatt gccataggaa
    37921 atttaaggtg aatgaatgta ttaactttat ttgagtccat agtcttaaat aaatttaaat
    37981 aatctttatc aatattctca atgccatcta caaaacttat taatatagga aaaaaacaag
    38041 taagcattac catcaatact tttggcattg ttccaaatcc aaaccatatc ataaagagtg
    38101 gtgctataat tattgtaggt atcatctgtg taaccaacat aataggataa agacattttt
    38161 ttattattga tacaaaatcc atcaatattc caattaccaa tgatattata attgcgacta
    38221 taaaaccaag tattgcttct cctatagtaa ccacagcatg tatggataaa ttttgataat
    38281 ctttaaaaaa cacattaatt atatctactg gtgtgggtag tatatactga ggaacttcta
    38341 aaactcctac catagattgc caaagaataa gtataaacaa aaatgttgct attggatata
    38401 tactatcttt gactttatct atgatttcta agtttttcat ctatagtcag acctccagct
    38461 ttttcatcta ctctagctac tgttatgact ctttcacatc caagattaaa agggatttta
    38521 tgtacctttt ttaataattc aaaaacttca tcaaaatcac cttcaacagt agtgctcatt
    38581 gctcctattt cacatttaag accacttttt tcaatttcag caatacaagc atctactact
    38641 ttatacatct cttcttcacc tttgtaaggt cttagtggca ttactgctat gtctgcgatt
    38701 accatttaaa tcactccttt aaaaataatt aatacctact aggtatattt tgttttttat
    38761 taaaaaattt tattactaaa aagatattat atttaaataa aagaaaagtc ttatccaaaa
    38821 taggataaga cttattttta tcttaactgg tctccctaca ctggcattat ccaaacaggt
    38881 tcaaagggtc gagataaaat ctcctctcag cacattagct ccccgaaata tattatatct
    38941 tttctacttg attatactac acttatcata ttttaacaaa ttttttattt atattagata
    39001 ttttatccgt tcaaaaatat ctaatataaa ttgtacatta ttacaccaaa taaattatct
    39061 taaaatggta atttatcaac atcttccaaa actagattaa ctgaattttc tagtttttat
    39121 tttgctattt caagcatatt tggatgtata tcaattccat acaaatattg tgctaaattt
    39181 ctgttttcac tcatctaatt tgcaatcgtt acaaattaca gattagaaat agcttttaga
    39241 ctctacttat ctttatctac aaaaaatcct tcaataaatt cattaataat attcagtaat
    39301 ctaaaaataa acctctatct agatttttaa gatacaagcc ttttaggaag tatcttttgt
    39361 gataatataa aaattactca tcattatcat caaaatcctc agcaaccaac attttagata
    39421 agaatcaaac tctataatat aattatttta tccaatttat ttttgagaaa taaaatattt
    39481 ttttaatttt taaatttttt aatatgcacc ttgaaaaaag aaacgttttc ctatattatg
    39541 gtaatagtag aataaaacta aataggcaaa actagagaaa tttagtgacg caaagctata
    39601 gggactaaga cttatgaaat gagttatgtc agccagttgc caaagagata ttttcttttt
    39661 gtttttatga atgtttttta gggggatata tgatatatgt ttatggataa aatggataga
    39721 tgtacacata tactaactgc atatatatgc agttcacgcg attactgcaa ttttatagat
    39781 acacaattaa atgattttat actagaatat ggagagaatg tggtagaatc ttgtttgcat
    39841 caagtgatgg tattggtaag cagatataat taaagaaatt ttattttcta gaaaaccctt
    39901 tttagtttta tctacgtttt ataattcatt aaagaactaa ttaaaataag cttcattata
    39961 tatttttcat aaagtaaaca gttgagttta tctcatatac tgtttacccc aattacataa
    40021 ttctaataat atagattcta atgatttacc acgtttagta gacaaatatt caacttttgg
    40081 aggaatagtc ggataagaaa tcctcttaat aagtccatct ctttcaagat actttaattc
    40141 ttgtgacagt atcttatgac ttatatgaac aacttctttt tttaattgac tgtaacgtat
    40201 tggctcttgt tttaaaatat gccataaaat aattgccctc catttacttc ctatcacagt
    40261 catggtaaaa ccaattgaac aattaaaatc tttttgtctt tcttcaatat ttggaaattc
    40321 ttcaaaatta ttatctatat ccatctcaat cctctctttc aaaatagtaa gtatctaact
    40381 aaaaagtgca ttcttgttta gcgtactaat tcgtaatata atcttgattg tagtatagag
    40441 ccttacataa tactactttt ttagatgtat atgtttaaac tttaatatag acatatgtta
    40501 ttttattaat tttatttaaa cagataataa taaataataa tttatctcaa gttttctatg
    40561 tagataaact aatctaatgt ttagaaagga ttatataata tgaataaaaa atttcgtctt
    40621 tatcaagttg actcattaca aaagaaaaat ttacaggtaa tccagctggt gtaattacaa
    40681 atgctgatgg cttatctgaa tcacaaatgc aaaaaatagc aagagaatta aataattcag
    40741 aaactgcttt tattttcaat aacttggcta aaaatcatca agaaaattat gatgtacata
    40801 tcagattttt tacactaact aatgaggttc ctatatgtgg tcatgctact attgctgccc
    40861 attatgttag agcagtagaa aaccaattca ataacaaaac agtatttcaa aaaactagtg
    40921 ctggaatatt accagttgat attataaaaa aagataatga ttatgaaata attatgacac
    40981 aaggaaaaat tgaagtatct ccaccgttac aacaaaccta tcaaaaaaga ttacttaatg
    41041 catttggtat tttaaaggaa gatattcgta cagattgtcc tattgccata tcatctacag
    41101 gacattcaaa agttatgatt ggaataaagg aattatcaac attaaatagt ttatctccaa
    41161 atttatatga attatcgaaa ataagtcaag aaataaaatg taatggatat tatattttta
    41221 cattacataa taaagaaact ctacaagttc atggaagaat gtttgctcct gcaattggta
    41281 tttcagaaga ccctgttaca ggaaatgcta atggaccctt aggtgcgtac cttgtacatt
    41341 ataaagtaat acctacaccc aacacagagt ttatatttga agcagttcaa ggagaaacaa
    41401 taaaacgcaa aggcaagatg ttagtaaaag taattatttt agataataaa ccagttgaag
    41461 taaaaataat tggaaaagct gtaattgcat tctcaacaaa catagaaatc taattataga
    41521 ttccttctaa gtaaattttt gaacttttta atactaattt aataacaaac taatttatat
    41581 acaatcaaat taattttttt attatttgtt aatatatatt tatcattata ttatataata
    41641 atatagatag ttactatatc ttataattag ataaatcata attatatatt attgttaaaa
    41701 ctcaattata taatttttaa taatattatt ttaggaggta aaaatgataa acgatattaa
    41761 aaataaattc aaaaattaca aaccatatat aaatggatac aagaatatga agagagcatc
    41821 tgttttaatt ccaatagtag aaataaataa cacacactat atattatttg aagttcgctc
    41881 aaaaaatttg aagcatcaac ctagtgaaat ttcttttcca ggtggtaaaa tagaatcagg
    41941 tgagactcca tatgaagctg ttattagaga aacttgtgag gaacttggaa cttttagtga
    42001 caatatagaa gtaatatcaa gtcttgacct ccttataaca ccagtaaagt ttatcataca
    42061 tccatactta ggatatataa aaaatattaa taatttaaat ataaacaagg atgaagttga
    42121 ccatactttt ttggttccta taaaatatct tttagagaat cctccaaata cttatagtaa
    42181 tactgtaaaa gtttttccag acgaaaatct accatatggt tcaattccaa accaaaaaga
    42241 ttataaattt gaaagtggaa gttatcctat tctgttttat aaatataaag attatgtaat
    42301 ttggggaatg acagcaaaaa tactagaaaa ctttttaaat tttttatcag aataacactc
    42361 ataataaatc atcaaaactt ttacataaga aatttataaa agtttctaaa tttaacaatt
    42421 ctaaaatatc aataactata ttttgtagca cttttttatt ttattattgt ttgaatattt
    42481 gatggttttc aatgcaattt caacataaat actatgtatt agtgtatact gttgatgaat
    42541 taaagtatga taatctattt aataaagtat gaagtaaatg attttaatgt gcctttatgg
    42601 taaaattact aataagtaat aaaattaatt aaaatatatg gaggtgctta taatgtttgc
    42661 tgtaggattt gttgttataa ttgcacttgc ctttttcatt ttaagtgtac tattatttaa
    42721 tggaaaagcc agtatgctac tagcaggtta taactctatg agtaagaaag aaaaagcacg
    42781 atacgataaa aaaaaattat gtagaagttc tagcattgtt acttttattg tctctataat
    42841 gctatttatt atggcgtttt tgggatatag aatagagagt ggtcaaatgg acgaaaaaaa
    42901 aatggttccc ttttctataa tatttataat agtcatactt tccagtgtat tttttaatat
    42961 cctctactct aacaaaaaat gtaaaaaata aatagttgta agttgagcag ttaattataa
    43021 aagattgact gctttttcat gtatattgac tactcttatt aaatatttta acatttaaaa
    43081 atctatgtaa aaataatgaa tatagtacaa acttctaata atgattttac ctttgtggtt
    43141 acagtccact atatataatt taatatgata acagggaatt actaatgaca actaggtaag
    43201 cttttataaa atataataaa acaaaaatag atgtacaatg aaattatatc ttatatcaaa
    43261 tttattttta ttaatagcaa aaacttacat tagcataaca tatgacaaat tcgcttaaaa
    43321 taaaaatttt taatataatt tgttctatag tacatctatt ttgattagtt tacataattt
    43381 tattattttg tacaatatta attatttact aatatcccat ttaatgaaaa agttctaggt
    43441 tcagtaattt ttaccataac taatttacca attaaatcat catttccacc ttcgaaattt
    43501 acgagtttat tttgtctagt tctaccagca aacttatttt cattattttt acttcttcct
    43561 tcaactagaa cttcaactat tctatcttta tatccatcat ttatttctgc agaaatccta
    43621 tttacagctt ctaacaccct attaaatcta tcatgcttta tatcttctgg tatttgattt
    43681 tccattttag cagcaggagt tccctgtctt ttagaataaa taaatgtaaa agctgaatca
    43741 tatctaactt tttcaaccac atctaaagtg tccaataaat cttcttctgt ttctcctggg
    43801 aaaccaatca ttaagtctgt agaaaaagca atacctggaa cttccttttt agctttttct
    43861 attatttcta aataatattc ctttgtataa tgtctattca tttttttcaa aaggctactg
    43921 cttccacatt gtattggtag atgtaaaaac tcacacacct tatcacaatc tctaattgcg
    43981 tatattactt catcagatat atcttttgga tgagatgtca taaatcgaac cctttcaatt
    44041 ccttctatat cattcacttt tcttaaaagt tctgagaatg aaactggatt ttcaagtgtc
    44101 ttaccataag aatctacatt ttgtccaagt aaagtgattt ctttcgttcc atttgcaaca
    44161 agctctttta tctcgttaat tatatcttca ggagttctac ttctttctct tcctcttgtg
    44221 tatgggacta tacaatatgt gcagaaatta ttgcatccat acattatatt tacaaatgct
    44281 tttaattcaa attttctatt acttctaaga ccttctatta cttctccatc cacatcccat
    44341 acatccacta acattttgtc agaatttatt gattctgtaa gtaattgcgg aaatttatat
    44401 agattatgtg ttccaaatat aaggtctaca tgtttatatt tttttcttaa ttcctctaca
    44461 acatgtggtt gttgcatcat acatccacat acagctattt tcatatctgg attttttcct
    44521 tttagatgtt ttaattgtcc taagttacca tacactttta gctctgcatt ttctctaact
    44581 gcacaggtgt tatatattat taaatcactt tcttcaacca tcattgacat ttggtatccc
    44641 atctcttcta acattgaaca taatttttct gaatcatgtt cattcatttg acacccgaag
    44701 gtttgagtaa acacgagttt tctctttcca gttctgttga agtattcttc attttgtctg
    44761 tgtatttgtt ctatatattt atcttgttct tgtattttct ctataggtat tgttacttgt
    44821 tttcttttgc tcacgtctat tcctcctagt taatttctta tattacacat aaccttaatt
    44881 atatcaaata agaaaaatct tttaaagata ttattatttt tctagttgtg ttttaa
//
LOCUS       DAEQCW010000019        44460 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.019, whole genome shotgun sequence.
ACCESSION   DAEQCW010000019 DAEQCW010000000
VERSION     DAEQCW010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 44460)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44460)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44460
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.019"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            106..246
                     /locus_tag="KRO40_001108"
     CDS             106..246
                     /locus_tag="KRO40_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091936.1"
                     /translation="MGIIESASKLAEMVHLLAVEKGITDIEAWDEAVKEYSKIYEERR
                     NE"
     gene            complement(421..741)
                     /locus_tag="KRO40_001109"
     CDS             complement(421..741)
                     /locus_tag="KRO40_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBH2091937.1"
                     /translation="MKLKTISLPELNNLDPTLESTFIKMGEEQGELAECIGKFRNLSG
                     ENNDLDEVDIIKKTAKELMDVAQTCVTMMFKLEEQYGINLDEIRKEHIKKLEKRGYIK
                     NMDK"
     gene            complement(861..1598)
                     /locus_tag="KRO40_001110"
     CDS             complement(861..1598)
                     /locus_tag="KRO40_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent protein deacylase"
                     /protein_id="HBH2091938.1"
                     /translation="MDANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKL
                     NKQFTAEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAHIALAKLEEMGKLKAVIT
                     QNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLGGNIPYCDNCGSIVKP
                     DVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYKGDYIALINKAN
                     TVYDKSASLVINKPIGEVLYEAVLRQI"
     gene            1813..3636
                     /gene="acd"
                     /locus_tag="KRO40_001111"
     CDS             1813..3636
                     /gene="acd"
                     /locus_tag="KRO40_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosaminidase"
                     /protein_id="HBH2091939.1"
                     /translation="MKKKAALATLAMLPLGVVNAHADGDIGIVTINYLNVRNEPTAES
                     SIAFVAKKDDKVLIKDSSNGWYKIKAESGQEGWASSKYIAKSNSDSLRTSTNKEKQVI
                     SNSLNMRNGAGTSYRVITVLKKGQKVEVISESNGWSKIKYDGRLGYVSSSYLGDVSNS
                     TNKSKTKQVNTTSLNVRSGPNTSYGLLGKLPKGSKVEVISESNGWSKIKYNGKDAYVS
                     SMYLSDVSQSNSDNSSQSNDKKNTDKVVNTASLNVRSGPGSTYSKLGKVYKGSKVTVL
                     SESSGWAKINFNNKEAFVVGNYLSTSADTSNNNSNSNSDNSSNSNGNNSSSSGQVNGM
                     SGISGAKIDYKSLSYTLESHISKQVEKAASGGNVIAPSNRKSTPSPEFSTFSAQRTSS
                     FVNASSSDIEYYLNPKNFTNTTKGMMQFLKINSYRDGISESSLNSYLNGLSSSVFKNQ
                     GAAFINAAKKYNIDVVYLVSHAMWETAYGKSTLAQGQTLTSYKGQPLSKPVKVYNFFG
                     IGAIDKSANVSGAEAAYSNGWTSVEATIDGSAKWISQNYVNSSKYNQNTIYKMKWNYD
                     YTWHQYATDVNWANGISGIMENLIGLYGGGSSLVFEVPQYK"
     gene            3851..8149
                     /locus_tag="KRO40_001112"
     CDS             3851..8149
                     /locus_tag="KRO40_001112"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HBH2091940.1"
                     /translation="MESIKEYLDKLEINNSGLGKQLKEVYINRVVYFKEDKIVYFYLT
                     SKDIVSHELLDKFKEELMYKLDYFKDMRMKIRFTGLERKSNKDVIKKYWNNILYILKY
                     LCPSIAGWYKQVEFLCLEEELKIKLPKGIFYERLMKKNVTYVLKTVLSEELGLDLNIT
                     IEKAVDEKVNKERLIRINDREMEEKIRALEIGKVNNCEENEEESYVIKSDVDENLIYG
                     DNANAMIENIVELNASSGTVAVVGDIFDVDTKELKNGKILMIASITDYTSSISCKLFL
                     TDTNKDGVLENVKKGAYLKIKGDIVYDTYQREISMMISGIRKETRIEREDKSEEKRVE
                     LHAHTQMSSMDAICSVKKLVERAAKWGHSAIAITDHGVVQGFPDAMNAGKSNNIKILY
                     GVEGYLVEDDSLIIEDANDKELSQTFVVFDIETTGFSNTNDKITEIGAVKIENFKIVD
                     RFSELINPEKDISYKIQELTGITNELIKDKPTIEEVLPKFMEFVGDSVLVAHNAEFDT
                     GFISQKCREQGLLYNNKKVDTLMLARVMLPNLKRHRLNVVAKELGIPLLNHHRAVDDA
                     EATALIFNKFLQMLTEKGAKTLSDVNNILGKIDYTKLSTNHITLIAKNSIGIKNLYKI
                     ISDAHVNHFFRAPRILRSVLNEYKEGLIIGSACEAGVVFQAVKKNVSDEEMKKIIDLY
                     DYIEVMPIDNNRFMIDKGEVKDEEELRELNRKLIDTAKKFDKIPVATGDVHFLDKHEA
                     VLRKVLKYSQGFKVDEEETYLHFRTTDEMLEEFSYLGEELAYEVVVENSNLIADMVED
                     IKPIPDDTYPPIIEGSDVELREMCYKKAKRIYGDPIPEIVQKRLDRELNSIISNGYAV
                     MYIIAQKLVAKSLSDGYLVGSRGSVGSSFAATMSDITEVNPLPAHYICENEDCKYSFF
                     YEIGEWGSGVDLPDKDCPKCGRKLAKNGHDIPFEVFLGFEGDKEPDIDLNFSGNYQPT
                     IHKYTEELFGEGYVYRAGTIGTVAEKTAFGYARKYVEENNISVPNAEVLRLSNGCTGV
                     KRTSGQHPGGVMVIPDYKDVYDFTPIQYPANDTSCGVITTHFDYHSISGRILKLDILG
                     HDGPTIIRMLEDMTGINITEIPLDDKETMSLFTSTEALGVTPEEINCPIGCLAVPEFG
                     TKFVRQMLLDTKPTTFAELVRISGLSHGTDVWVNNAQDLVREDIVGLKDVISTRDDIM
                     NYLIFKGLPPKMSFTIMESVRKGKGLKPEHIEEMKKNNVPEWYIGSCKKIKYMFPKAH
                     AVAYVMTSFRIAYCKVHYPEAFYATYFTTKVEDFDADLIVKGLDAIKSKINEIESLGN
                     DATTKEKGMLTVLEVALEMYARGIKLLPVDIYKSDATEFIVVGEKTLLPPMAAIQGLG
                     GNAAINIQNERKNGEFISKEDLRKRTKISKTVIETLTNHGSLENMSERNQLSLF"
     gene            8353..8814
                     /locus_tag="KRO40_001113"
     CDS             8353..8814
                     /locus_tag="KRO40_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HBH2091941.1"
                     /translation="MKKNLEATIEEIVTKITDEHGFEMVDVEYVKEAGEYYLRVYIDK
                     EEGISLNECELVSRELSPILDEKDPIKENYFLEVSSPGLDRALKKDRDFVRYQGRDVD
                     LKLYKPLNGCKQFEGELVGLTEDNNIKIIANGKEMEFNRKDVAIVRLAIKF"
     gene            8844..9998
                     /gene="nusA"
                     /locus_tag="KRO40_001114"
     CDS             8844..9998
                     /gene="nusA"
                     /locus_tag="KRO40_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HBH2091942.1"
                     /translation="MNHEFMEALDELVVDRGIDKEILIDTIEQALLTAYKKNFGSAQN
                     VRVEFDRDKGDIKVFSQRVVVDESDLYDTFLEIELADAREINPNYELGDIIEHEVTPK
                     NFGRIAAQTAKQVVVQRIREAEREIVYNEFIEKENEIVTGEVARANKNVVYVNLGRIE
                     GIMTQSEQIPFENYKAGQKIKFYILEVKKTNKGPQIVVSRSHPGLVKRLFEEEVPEIY
                     EGIVQIKSVAREAGSRTKMAVRSIDEKIDPIGACVGPKGLRVKNIVDELGDEKIDIIK
                     YSEDPAEFISAALSPSKVVRVDIDEDEKSALVIVPDYQLSLAIGKEGQNARLAAKLTN
                     WKIDIKSESQAEQEMLNLENSKEIEAEDVEAEFIDQEELDTSEDNFSEEE"
     gene            10005..10286
                     /locus_tag="KRO40_001115"
     CDS             10005..10286
                     /locus_tag="KRO40_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HBH2091943.1"
                     /translation="MILKKVKKVPQRKCIACQDRDSKKELIRIVKNKEGKIFLDPTGR
                     ANGRGAYVCKSSECLKKAIKSKALNKAFKIDVPDEVYDNLLMELEEYEK"
     gene            10276..10587
                     /locus_tag="KRO40_001116"
     CDS             10276..10587
                     /locus_tag="KRO40_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal L7Ae/L30e/S12e/Gadd45 family protein"
                     /protein_id="HBH2091944.1"
                     /translation="MKNNKEKVLSFLGLATRAGKIVSGDDSTLLDLKKGKVNLILIAE
                     DASNNTKKLFKDKSTFRNIPYLFFSTKEEIGFAIGKSPRAVVGIKDENFSKKIIELIE
                     I"
     gene            10609..12549
                     /gene="infB"
                     /locus_tag="KRO40_001117"
     CDS             10609..12549
                     /gene="infB"
                     /locus_tag="KRO40_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HBH2091945.1"
                     /translation="MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELE
                     LALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEIS
                     FEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG
                     KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQV
                     TDIAILVVAADDGIMPQTVEAINHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGL
                     LVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKRAVGTVIEAELDKG
                     RGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVP
                     QGGDQFVEVPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVI
                     KADVQGSVQAVKQSLEKLSNEEVQVKVIHGGVGAVTESDILLAAASNAIIIGFNVRPV
                     PGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIYKISGV
                     GTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVN
                     YNDIKEGDIVEAYITKEVERKL"
     gene            12592..12972
                     /gene="rbfA"
                     /locus_tag="KRO40_001118"
     CDS             12592..12972
                     /gene="rbfA"
                     /locus_tag="KRO40_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HBH2091946.1"
                     /translation="MASYNRTRRIAEEIRKVVSTMLINGVKDPRITSMVSVTDVEVTN
                     DLRYAYVYVSILGGDEESTLTGLKSAGGYIRREVGKNIKLRYIPEIVFKLDDSIEKGM
                     YMDSLIKRVNEKNAQQNEDENYDE"
     gene            12953..13936
                     /locus_tag="KRO40_001119"
     CDS             12953..13936
                     /locus_tag="KRO40_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HBH2091947.1"
                     /translation="MKIMMNNMDSIINYIYEGDYFIVTSHISPDGDNIGSTLSMYYTL
                     KNLGKNVYYVLDDEAPLNLRFLVEDVKIYKSNEFNMKNYSLIALDCGDKMRICVSDEI
                     KNNASKLICIDHHASNDSYGDLNYVDIDASSTCELVYNLLVRFQQIKDINIINEDIAT
                     CLYTGLVTDTGNFSYSNVHASSFEMAKNLLVLGAQKNTIIQNIYQSNSSGYYKLLGEA
                     LKGLEIFDSKVSSIVLTQDMMNRNNISFNDVDGITTYTRDIKGIEVGILFKEKKQNEI
                     KVSFRSKNYVDVSEIAKLFGGGGHVRAAGCTIRDSIDNAKKMVLEAVLKSI"
     gene            13949..14854
                     /gene="truB"
                     /locus_tag="KRO40_001120"
     CDS             13949..14854
                     /gene="truB"
                     /locus_tag="KRO40_001120"
                     /EC_number="5.4.99.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HBH2091948.1"
                     /translation="MNKIISILKPTGMTSHDVVSRVRKILNIKKVGHTGTLDPDASGV
                     LPICIGKATKVCEVILNKDKSYICELTLGISTDTYDASGEILKKVDDFKFSNEDIERA
                     FDTQRGEINQLPPIYSALKVNGKRMCDLVRSGRQSEITLKTRRVNIKDIKILSIKGNK
                     VMFYVECSKGTYVRSICHDIGEYLGCGAHMSFLNRTSSGKFDLDNSITLEELELFYEN
                     KTLDKYLYDIDYVLDSFNYVVLNPNAIKYYSNGGSIDDKRFLKNNFDKDDEFVRVYST
                     DNFLGLGKLSKHNNTISVKSDKMFI"
     gene            14985..15914
                     /locus_tag="KRO40_001121"
     CDS             14985..15914
                     /locus_tag="KRO40_001121"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HBH2091949.1"
                     /translation="MVIIKSIKEIANIKESVITIGNFDGVHKGHQVLIGKTVEHAKKE
                     NIQSIVFTFANHPVNYFRPNSTKNIISNDDKIKLLEDLGIDIVVIIPFDEYMTKIPAK
                     DFVDEILVKKLKAKKIVIGHDFTFARAKEGNVNLLKSLEHEFGFEVEVIKPIKINDVR
                     VSSTYIRSLVSQGDMANVKEYLGRNYKLEGCVIHSKHLGRTIGFPTANIDLKNNMLVP
                     KRGIYASIVHIGDETYFGATNVGYNPTVNGKTLSIETNILEFDRDIYGENIIVEFLER
                     IRDERKFNSIDDLKNQLYNDTNYVYENYVCKNK"
     gene            16018..16275
                     /gene="rpsO"
                     /locus_tag="KRO40_001122"
     CDS             16018..16275
                     /gene="rpsO"
                     /locus_tag="KRO40_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002843739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HBH2091950.1"
                     /translation="MINKSEIIKEYGRAEGDTGSPEVQIALLTARINELNGHLKTHKK
                     DHHSRRGLLKMVGRRRNLLAYLKEKDLEGYRALIAKLGLRK"
     gene            16515..17360
                     /locus_tag="KRO40_001123"
     CDS             16515..17360
                     /locus_tag="KRO40_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH2091951.1"
                     /translation="MKIKLVCDSLCDIPDEISEKDYIEIVPLTVIFNDREYIEGVDIK
                     KEEFYKKVKEIKQIPKTSQATYMEFKEVFDKFITEGYHIICMTGAANASGTFQSAMIA
                     KNDVNENEKIHIFDTRNLSLGSGQYVIKACELLEEGLGFEEIIDELENTRSSVRLLFA
                     PYTLDFLKQSGRVPVATALIGNMLNIKPIFFFDNGEAKLVNKVRGIKNIASKLVDIIL
                     EMNEGSLEGKIVTIGCGDNLHDCEILKDEVNKRIKARRVLFTRGGVSICSHTGPDILA
                     ISCSN"
     gene            17485..19596
                     /gene="pnp"
                     /locus_tag="KRO40_001124"
     CDS             17485..19596
                     /gene="pnp"
                     /locus_tag="KRO40_001124"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HBH2091952.1"
                     /translation="MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNT
                     TKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPL
                     FPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
                     FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEF
                     IEGIVAEVGKEKMPVELYHAGEEITQLVREFATDKMKKAVQTFEKLERMENMDRVKEE
                     TLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETG
                     MIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEA
                     RPSRGPGRREIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTL
                     SLLDAGVPIKDMVAGIAMGLIKHDGKVAVLSDIQGMEDHLGDMDFKVAGTEYGITAIQ
                     MDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKMQINPDK
                     IKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVG
                     KTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEID
                     EKGRVNLSRKVLLPKPEHKNK"
     gene            19862..20605
                     /locus_tag="KRO40_001125"
     CDS             19862..20605
                     /locus_tag="KRO40_001125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2091953.1"
                     /translation="MIMMVLNKSKLKKIIILILVVLLVLSGGVMVLKLFNNKPVFNLF
                     NGVDLPYERGTKDKSGYVALTCNIDLGWETEYVESILETLKKENVKITFNVTGKWAEK
                     NKDELLKIKKQGHEIGNHGYKHLDYSTLSYEDNYEQIETSKKIIEEIIGEKTKFFQAP
                     AGSFGPETVKAAKALGYTSIKWDADTIDWKYKDQPEVIIDRMKKKDIKDSSIILMHPT
                     NATTKCIDDIIAIVREKGLKPGKLSDVFK"
     gene            20763..22010
                     /locus_tag="KRO40_001126"
     CDS             20763..22010
                     /locus_tag="KRO40_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH2091954.1"
                     /translation="MYKTKILENGLTIIGEEIPYLKSITLGIWINAGSRIEEAQVSGT
                     SHFIEHMMFKGTKNRTSKEIASSIDNLGGQINAFTSKECTCYYVKLIDEHIDTGIDVL
                     SDMILNSKFDKNDIDKERLIILEELKMYEDSPDDLSYDLLVENIYANDGLGMNIIGTK
                     ESLYNITRESMLEYLNKYYIPNNAVISIAGNFNFDDMVEKIKSKFGHWEKKNLSIDIS
                     EAKFNPCFISKNKDTEQVNLAMCLKGIPFENDEEVYSMAVVNNIFGGSISSRLFQKIR
                     EEKGLVYSIYSSQTLYRKCGELGIFASMSTENLQDVYNLIKKEIENIRENYLTEKEIS
                     ESKEQLKGNYILDLESTSSRMMSTGKSMLLSKKVKTTDEILECINNVNINSIKKVVDK
                     VFNIENIGTCIVGRDVEKILHLD"
     gene            22045..22290
                     /locus_tag="KRO40_001127"
     CDS             22045..22290
                     /locus_tag="KRO40_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBH2091955.1"
                     /translation="MNLSEIAGKEIVNLVTGERLGVIGECDLILDETTGGILALLIPK
                     EKGFFARRKDKSFLEVPWRNVKKIGNDMIIIEYEGYI"
     gene            22300..23523
                     /gene="dapG"
                     /locus_tag="KRO40_001128"
     CDS             22300..23523
                     /gene="dapG"
                     /locus_tag="KRO40_001128"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBH2091956.1"
                     /translation="MSILVQKFGGTSVESYEKMNEVCKIVKAYKKNDEELQLVLVVSA
                     MGRKGAPYATDTLINLCSAVNDEPSKRELDLIMSCGEIISGTILANLLNAQGIDSVFF
                     TGQQAGIITSDEYSNAKIKYINPKKVKRALDDGKVVVIAGFQGVTDDGEITTLGRGGS
                     DTSAVAIGKALECETVEIYTDVDGIMTADPRVEPNAKVLSFIDYEEVFQMADKGAKVI
                     HPRAVQLAKSGNITLAIKNTMNPTFEGTKIGSLCRHLEDNIEYEQERDFKVAVANKDS
                     VAQVKIKSAEEVFTEVLNEIEKKLITIDMINFFISEKAFVVEDADIKSLKEILDKFEL
                     DYEVNRDCAKVTLICSRIADEMSGIMSKVVRGLSKAGVSLLQTSDSNMTISCLVSEED
                     MHTAVHAIHQQFYLK"
     gene            23636..24370
                     /locus_tag="KRO40_001129"
     CDS             23636..24370
                     /locus_tag="KRO40_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="HBH2091957.1"
                     /translation="MKDYREDNERFDKDNCSEESSCEERECIKQFGTNEMPPQPPKDI
                     QCITIIGEIEGHFIGNPQKKATKYEHIIPMLYSIEESNDVKGVLVVLNTVGGDIEAGL
                     AIAELLNSTSKKVVTLVLGGSHSIGVPLATAGDYSFIAPTATMIIHPVRTTGLVIGIN
                     ETFEYFKKMQDRIIQFIIRTSNIKKDVLEKLMHEKDELVSDVGSVLIGKEAVDYGLID
                     EVGGLKEALKKLRELIKESEEEKNND"
     gene            24493..26904
                     /locus_tag="KRO40_001130"
     CDS             24493..26904
                     /locus_tag="KRO40_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HBH2091958.1"
                     /translation="MATKKKKKKKVNTLSFNAEYHNLITIFIGVFLLYSLNSNSMGWI
                     PVLMQNLFKGLFGGLSIAIPFIVIITGLLGFFDGNEYIYRLRKTKLYYIIILFIFVFY
                     GLLNAGTLPVDSPLKGNMFDDVMKLGVSGQGSGLIATTIAYYMSKIFGIAGGWLISIF
                     ALILSVMFIFNISIKDLVSNAKSKSKASKDSNLTFKDKIANMKKSAIDMMTDEVDDTT
                     INKKPGFFKGLMSKGLNNDDEEDEYFEEENSDGVDDKTIKIVGFNKAEDEYLEILEGT
                     QSMPELDVLKELQKATNENPVVDTKPEKKVDIAKPNLNIEKTQPMSIVAEPVNEDYSN
                     YKKPSIELLNKVNKKSDENGKKKVLKNASLLEKTLSDFGVEAKINQVTVGPTITRYEI
                     QPSPGVKVSKIVNLTDDIALSLAAKSIRIEAPIPGKSAIGIEVPNEEAQMVGVREVLE
                     SEEFNNFNSPLAMGLGKDVAGKIIIGDIGKMPHLLIAGSTGSGKSVCVNTLISSILYK
                     ANPDEVKLLLIDPKVVELANYNGIPHLLIPVVTDPKKAANALNWAVTEMNRRYKLFAD
                     AQVKDVTSYNEKAEEKLPKIVIIIDELADLMMASANDVEDYICRLAQMARAAGMHLIV
                     ATQRPSVDVITGVIKANIPSRIAFAVSSQTDSRTILDMGGAEKLLGKGDMLFYPLGAA
                     KPVRLQGAFISESESEKVIDFVKSQVKDGIKYEEDIIETISKVNTSKGSDEDEFLSEA
                     IEFVVESGQASASMLQRRFKIGFNRAARLIDSMEERGIIGASEGSKPRKVLISKQDLQ
                     NLEGE"
     gene            26907..27965
                     /gene="mnmH"
                     /locus_tag="KRO40_001131"
     CDS             26907..27965
                     /gene="mnmH"
                     /locus_tag="KRO40_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-selenouridine(34) synthase MnmH"
                     /protein_id="HBH2091959.1"
                     /translation="MSVIKIEKALKLDKVIFVDVRTEGEYEEDHILNAINMPLFKNNE
                     HNDVGTIYKMQGKHEAIQKGFDYVSYKLKDIYLQAAELALNYDNIVIYCARGGMRSGS
                     IVNLLSSLGVNVYQLEGGYKAYRNFVLEYLRHVMDTKNFVSVHGLTGTGKTDLLHLLD
                     EKGIDVLDLEGIAKNSGSTFGFITFDKKPPSQKNFETKLFESIFFSKENYIFVESESK
                     RVGSVTVPNEIFEAMTREGHHILLECDIENRVDRLCRDYIYDKDEGNILILKECINKF
                     RKRLGNKVVDDYIDLLESGEYKELVKRYLLEYYDPLYMHSVEKYKYSKIINFNDTQKA
                     LEDVIDLYESILEGESEC"
     gene            27959..29293
                     /gene="rimO"
                     /locus_tag="KRO40_001132"
     CDS             27959..29293
                     /gene="rimO"
                     /locus_tag="KRO40_001132"
                     /EC_number="2.8.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12 methylthiotransferase
                     RimO"
                     /protein_id="HBH2091960.1"
                     /translation="MLKIALESLGCSKNLVDAEIMMGILNNKGYKLIGDFEEADVIIV
                     NTCGFIESAKQESIDTIINFAELKKTGNLKLLIVTGCLAQRYSEELKTEIPEIDAIVG
                     TGSYQNIDKILKELSEMHKIVSLNDIEFVFNEDLPRYISTPSYMAYLKIGEGCSNNCT
                     YCIIPKLRGKYRSRKFEDIIKEAKKLAESGVKELVVIAQDTTKYGFDLYGKERLSELL
                     EELAKIDGFKWIRVMYSYPESITEELIQVIKKYDNICSYFDMPIQHASNNILKLMNRK
                     TTKEDILNKINLIRSNIPDAILRTTIIVGFPGETEDDFKQLVDFVEEVKFDRLGAFAY
                     SREEDTPADRLPNHIDEEVKIQRRDTLMMIQQKISEELNDKKIGKTYEVLIEEQIEDN
                     VYTGRTQGDAEEIDSIVYVKSVDNLEVGEFVSVQINDAMEYDLMGDVLYELA"
     gene            29280..29822
                     /gene="pgsA"
                     /locus_tag="KRO40_001133"
     CDS             29280..29822
                     /gene="pgsA"
                     /locus_tag="KRO40_001133"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HBH2091961.1"
                     /translation="MNLPNKLTLFRIFLIPVFVLIMLLNIPNKFLIACIIFIIASITD
                     ALDGKIARKYNLVTDFGKFMDPLADKLLVISALTCMIEDHLVSSWMVIIIVARELTVS
                     ILRAIAAADGKVIAAGNSGKLKTITQMVSIVFLLLGAQFENVLILNIGEILILIATLL
                     TLYSGWEYLYKNKELFMSSK"
     gene            30110..31156
                     /gene="recA"
                     /locus_tag="KRO40_001134"
     CDS             30110..31156
                     /gene="recA"
                     /locus_tag="KRO40_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HBH2091962.1"
                     /translation="MSVDQEKLKALNEALGKIEKDFGKGSVMKLGEATSMSIDVISTG
                     AIGLDIAIGIGGLPRGRIVEVYGPESSGKTTVALSCVASAQKDGGIAAFIDAEHALDP
                     VYAKALGVDVDNLIISQPDTGEQALEIAEALIRSGAIDIIVIDSVAALVPKAEIDGDM
                     GDSHVGLQARLMSQALRKLTGSIKKSNCVAIFINQLREKVGIMFGNPETTTGGRALKF
                     YSSVRLDVRKIDTIKQGDKVIGSRTRVKVVKNKVAPPFKQAEFDIMYGEGISKIGDLL
                     DIAADVDIVKKSGSWYSYNDTKLGQGRENVKKFLEDNLDLTTEIDEKVRAFYNLNEEH
                     EESGTSVSKEIVEE"
     gene            31332..32873
                     /gene="rny"
                     /locus_tag="KRO40_001135"
     CDS             31332..32873
                     /gene="rny"
                     /locus_tag="KRO40_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HBH2091963.1"
                     /translation="MDVIDSVVMIVIGAAVGIIAGYFVRKNISEAKIGQAENLAKEII
                     DKAHHDSETVQKEKLLEAKEEIHKWRTEAERENRERRTEVQKYEKRVVQKEEVLDRKL
                     QNLESKEVNLSEKLKVVEKKEEEVEVIKTQQLEKLESISGITSDKAKEIILTNAERDV
                     RREMSIMIKEIESQAKEEADKKSREIIGYAIQKCAADHVAETTVTVVSLPNDEMKGRI
                     IGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARIALEKLIADGRIHPAR
                     IEEMVEKARKEVDNIIKEYGEQAAFETSVHGIHPELIRLLGRLNYRTSYGQNVLKHSI
                     EVAHIAGIMAAEIGADIRLAKRAGLLHDIGKAVDHEMEGTHVEIGMDLLRRYKESKEV
                     IHAMSTHHGDYEPQTVEAVLVTAADAISAARPGARRETLEAYIKRLEKLEEIANSYEG
                     VEKSFAIQAGREIRIMVKPEAINDEEIHLLARDMTKKIEDELEYPGQIKVSIIRETRA
                     IEYAK"
     gene            33187..35523
                     /locus_tag="KRO40_001136"
     CDS             33187..35523
                     /locus_tag="KRO40_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2091964.1"
                     /translation="MKKNTLLHTNIMVCIIITLGFVATSIIGYQSNTNIFKNDIEHVS
                     TLAAEGIYYQIDKLLSEPINVSLTMANDSLLKNFLDGEKEHLNDEEFIYKLQDYLNVY
                     RNKYSYDSVFLVSTKTNNYYHFNGLDRNLSANNSENQWYYTFLKNDDEYSLNVDNDEA
                     SNNSITVFVNCKIKDDNGATMGIIGVGLKVNSLQMLLKGYNDKFDVVARLIDDKGFVQ
                     LAVDKTGHENINFFENSSSDLSNSKQLILNNKKEQKSFWYSSEKSKSYIVCQYIPSLK
                     WHLVLENDFTLMIKQLHLQFFKGIAVIVLIIIFVLFTITHVLKKYKNQIIKLSVSQKL
                     EYQKLLSKSTEGLYENIFEIDITNNKAGCEDENRYFHEFGLGLNTPYDEALHTIAKNQ
                     IKEEYAQGYLDTFLPENVIKRYNSGINNISYDFLIKKDEESYHWIRINARIFFWTSDE
                     SVRMISYRKNIDEEKNRELLLLERSQRDSLTGLYNKATTEEFIRSFLKNESNQDLEHV
                     FLIFDIDNFKNVNDKYGHVFGDFVISEFALELKSQFREDDIVGRIGGDEFVVLIKDFN
                     NNNYVLIDKLERFCSKINQKKFVEQAEFSIACSIGVAMYPEHGYVYSELYEKADQALY
                     YAKSHGKNSYHIFSEDSIDSISFHIDSRDIKVLLEMATDGVVKFACMENLKLLYFNQK
                     MLEFTGYSAQTVTSIGFDIFSPVLQDDLQMVLDTLREAISKRETFEIVFRFCHTDGHI
                     FPVRMQGKFVSELYQNRYPVFYAIYTDISSINTLLENK"
     gene            35905..37686
                     /locus_tag="KRO40_001137"
     CDS             35905..37686
                     /locus_tag="KRO40_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="HBH2091965.1"
                     /translation="MSQYININSQLDALKLKEFEKIFYENINEDVKVVPKVTPFKGIN
                     TDLLYVKDGRILFIKFMDTTEDIFFILEEELLEVMNEEYELLKLKMGQKNRNISYNYV
                     YIMPYVEVEETYEFEEFVNNNIIDKNKLQDIMNKGSLEEYLNDENDEINLNLFLLDIC
                     SEYYIINDKLHLNEKFKKISFYNDDYKYTATMMEDVQIKDVVSIKYGNTLIEGGSGIG
                     KTAIMLSRAIKLAKVYPHHKLVIFTHTKQLCNELRERIELLYKDNNNLEVHTFSSFIF
                     KLAKKFNLIVDYNMLKNDYEKTFNNLVKQAQNIIKNKNMFKAIFIDEAESFLEYEIDF
                     IREFLYKTKFIFNVCSCNSLNISNRLNIFKKLYNGIEFDDKIILSKNYRQAKEIVDFT
                     NKFSNNSNSYINELRPNTEFSTFFYTKALRGGNKSVDIIKVSDLDDQISSVIWEIEYL
                     ISKKGLDYSEVAIVYPYNKKKLKSGKTIYFQYMLKKALEEAKIPYICAEDNLTNISKK
                     VGTTIANIYAIKNLEYKAVIVCELEMLYNQTINDIEQDYQVNDFVGDLNKVYLAMSRA
                     TDYLSIVTTFNEEASDIIRLITESKDI"
     gene            complement(37768..38298)
                     /gene="lepB"
                     /locus_tag="KRO40_001138"
     CDS             complement(37768..38298)
                     /gene="lepB"
                     /locus_tag="KRO40_001138"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH2091966.1"
                     /translation="MSVKKEIFDWIKSIAMAIVLAFVILQFIRPSIVSGESMYPTLDD
                     KDYLILNRISYKVGKPEKGDIVVFKTNLVDGETGKKKDLIKRVIATEGDRIKISNSKV
                     YVNGKLLNEPYIHNNYTSGDIDTVVPKGKLFAMGDNRENSNDSRFPDVGMVDEDEVLG
                     KVMVRLLPLDNIGKVD"
     gene            complement(38338..39162)
                     /locus_tag="KRO40_001139"
     CDS             complement(38338..39162)
                     /locus_tag="KRO40_001139"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBH2091967.1"
                     /translation="METFSLLEIFKAVILGIVQGITEWLPVSSTGHMILVDEFIKLNF
                     SNTFISTFLVVIQFGSILAVLVIFFRKLNPFDSAKNIKQKKETVRLWLKVIIAVIPSG
                     VIGILFEDDIDRLFFNSTVVAIALIVYGIIMIGLEKRNKKPKYKDFSQVTYKLALCIG
                     LFQCLALIPGTSRSGSTIIGAVLLGTSRYVAAEFSFFLAIPTMLGASALKLLKAGFGF
                     TGFEWLILGVGSVVAFVVSIVVIKFFMDYIKKHDFKVFGYYRIVLGIVVLAYFFLL"
     gene            39419..40327
                     /locus_tag="KRO40_001140"
     CDS             39419..40327
                     /locus_tag="KRO40_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH2091968.1"
                     /translation="MYSTKILDDYEYETFNVFSTKLNPNTKHDYLSKVILFKEFLKGK
                     ELIYATKEDCKNFVDYIQTKYAKSTCEKIYSYLHSFYNFLKKEGYIDINPFRYVEKPT
                     VTRIKTKDDVLSIQEINKLIGILPKLNIRDRVIIVCLVTTGCLLNELVSLKWKDLMVD
                     ENDNSYVRLGKGRKERVVKLHPYFFKLLEDYRNYSGLPEVIIPSDDFIFTTQKSNSIT
                     DRNVRLIVKKALDLAGLSQYSARDFRHSFAAISLRLGADESDVKNQLGWSDKYYAIRY
                     KYVLNFVDSEIVDYLIEKDNLDINKK"
     gene            40471..41916
                     /locus_tag="KRO40_001141"
     CDS             40471..41916
                     /locus_tag="KRO40_001141"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HBH2091969.1"
                     /translation="MIDNKYTTYSNPLTDRYCSKDMSYIFSPQFKFSTWRRLWVALAE
                     GEHELGINITEEQLDELRANIDNINFDEARKIEKEVRHDVMSHVKAYGLQCEKAKGII
                     HLGATSAYVGDNTDVIQMNEALKLLRVKLVNLINNLKEFALKYKDMPALGFTHFQAAQ
                     LTTVGKRACLWAQDLILDLEDLNYRIDNMKLRGVKGTTGTQASFLSLFEGDHEKVKEL
                     DKKICKKMGYHSSYAVSGQTYTRKLDYQVISILSGIAQSMHKMTNDIRLLQSLKELEE
                     PFEKNQIGSSAMAYKRNPMRSERIASLSKYIISESISPAMVQATQWLERTLDDSANKR
                     LAIPQAFMAADAILEIGINVTDGLVVYENMINRRVNEELPFMATETILMEAVKRGGDR
                     QELHEIIREYSMKAAYRVKHEGKDNNLIELIMNDDSFKMSKEEILSIMDPKNFIGRAP
                     EQVVEFVNEVVEPAIKDYKEDLGKVDVDLRV"
     gene            42227..42679
                     /locus_tag="KRO40_001142"
     CDS             42227..42679
                     /locus_tag="KRO40_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2091970.1"
                     /translation="MNYIVKDTISFLVKTFPKIYSSLYLEDLKKFAPDYNVNKTQLRA
                     LVFIKNYGVISMTDLCSKLNIEKGSLTSMVDDLTDKKYVTRKRDLVDRRKYLIDITEE
                     GDKIATDFMDKLSDGLGEKLSKLTEEDRKKYLEAINTLQYILNKEEFR"
     gene            complement(43014..44210)
                     /locus_tag="KRO40_001143"
     CDS             complement(43014..44210)
                     /locus_tag="KRO40_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2091971.1"
                     /translation="MNYSNRVSAMQASPIRKLVPFAQAAKDKGIKVYHLNIGQPDIKT
                     PKGFFDAVKNFDSEVLEYATSEGIPELLEALQNYYKTYDMNFEKDELLVTNGGSEALL
                     FTMMAVCDPGDNLLVPEPFYTNYNGFGQSVNVEVNAVTTKAENGFHLPSKEEILSKVD
                     DKTKAIILSNPGNPTGAIYTKEELNILAEIAKEKDLWIIADEVYREFVYDGLEYTSCG
                     NLEGVQDRVIIIDSVSKRYSACGARIGSIACKNKGLIAQILKLCQGRLCVPTLEQIGA
                     VELYKTPVSYFKEVNEEYKKRRDVLYNELMKVEGVICKKPTGAFYIVAKLPVENAEDF
                     TIWMLKEFNKDNETVMVCPAEGFYATPGLGRDEIRLAYILNEKDLHRAATLLKEGLEQ
                     YVALQK"
BASE COUNT        17851 a         4909 c         8011 g        13689 t
ORIGIN      
        1 aataaaaaaa tttttattta ttagagtttt tggaaataat aataacagat attataatta
       61 attaacagtt tttgtaagta tttgacaata gagagggtgt aacaaatggg aataatagag
      121 tcagcatcaa aattggctga gatggttcat ttattggctg ttgaaaaggg gataactgat
      181 atagaagcat gggatgaagc tgtgaaagaa tacagcaaaa tttatgaaga aagaagaaat
      241 gaatagaatg ataaaaaatg aaaacttgat gataaaaaat aactttattt aaagaaattc
      301 aatttttata gaagtattaa aaataatata aataaaaaga tggtatttca aatgtaagta
      361 aaaaatcatt ttgggatacc atccttatta tttattttaa taatatataa gtaataaatc
      421 ttacttatcc atatttttta tgtaacctct tttttctagc ttttttatat gctccttacg
      481 tatttcatca agattaatac catattgttc ttctagctta aacatcatag taacacatgt
      541 ctgcgctaca tccattagtt ccttagcagt tttctttata atatcaactt catctaaatc
      601 attattttct ccacttagat ttctgaattt acctatacat tcagctaatt caccttgttc
      661 ttcacccatt ttgataaatg tagattctag tgttgggtct aaattattaa gctctggtaa
      721 agatatagtt tttagtttca taaaagctcc tttcaagtta ttcgtattta tactaaaaca
      781 tcataacaaa aataatacta aaaaaaaact ttaaattcaa cataaaaact tacatatata
      841 ataaaaatcg tgaaataaat ctatatttgt cttaatacag cctcatataa aacttctcca
      901 ataggtttat ttattacaag agaagctgac ttatcataga ctgtatttgc tttattaata
      961 agagcaatat aatcaccttt gtaataatct ataaaacttg ctgctgggta cacagctaat
     1021 gatgtacctc ctataatcaa taaatcagca ttacttatag cagaaattgt tttagtaatg
     1081 acatcactgt caagagcttc ctcataaagt actacatctg gttttactat agaaccacag
     1141 ttgtcacagt aaggaatatt acctcccaga tttaacatag attctaagtc aaaaaactta
     1201 ccacatttag tacaataatt tctatgtaca gaaccatgaa gttctagcac atttttactt
     1261 ccagccattt gatgaagtcc atcaatattt tgagttatga cagctttaag cttacccatt
     1321 tcttcgagtt ttgctaaagc tatatgagca ttattgggtt ttgcattagg atatattaat
     1381 ttatccttat aaaattcaaa aaattcttct ggatatctaa caaaaaaagt atgtgaaact
     1441 aattgttcag cagtaaattg tttattgagt ttttggctaa ataatccagt agaacttcta
     1501 aagtctggaa tattagattc agttgaaaca cctgctccac caaaaaatac aatattattg
     1561 tgattagcta ttaagtcttt taagctattt gcatccatag ttacacctcc aaattattat
     1621 atataaattg tactacatat taggtcgttt atgttttatt aatttaaata aatatatagt
     1681 ttaataagtt aaataaaggg aatataaata aaatgtatac agagtataaa tagacaatat
     1741 ttactaaaat aacaagttgt cgtataatta tattaaaatt gttttagtgt ataagaaggg
     1801 cgggggaagt acgtgaagaa aaaagcagct ttagcaacat tggctatgtt acccttaggt
     1861 gtggtaaatg cacatgctga tggagatata ggtatagtga ctataaatta tttaaatgta
     1921 agaaatgaac caactgccga aagtagcata gcctttgttg ctaaaaaaga tgataaagtt
     1981 ttgattaaag actcttctaa tggatggtat aaaataaaag ctgaatctgg acaagaaggt
     2041 tgggcttcat caaaatatat agcaaaatca aatagtgact ctttaagaac gtctacaaat
     2101 aaagaaaaac aagttatttc aaatagttta aatatgagaa atggagcagg tacaagttac
     2161 agagtaataa ctgtactaaa aaaaggtcaa aaagtagaag taatatcaga gagtaatgga
     2221 tggtctaaaa tcaaatatga tggaagacta ggatatgtat ctagctctta tttaggagac
     2281 gtttcaaact caactaataa atcaaaaact aaacaagtga atacaacttc actaaatgta
     2341 aggagtggac caaatacaag ttatggtttg ttaggcaagt tgccaaaagg aagtaaagta
     2401 gaagtaatat cagaaagtaa tggatggtca aaaataaagt ataatggaaa agatgcctat
     2461 gtatctagta tgtacttatc ggatgtaagt caaagtaatt cagacaattc tagtcaaagc
     2521 aatgataaaa agaatactga taaggttgta aatacagctt ctttaaatgt aagaagtgga
     2581 ccaggttcta catatagtaa gttgggaaaa gtttataaag gaagtaaagt aactgtacta
     2641 tcagaaagta gtggatgggc taagattaat tttaacaata aagaagcatt tgtagtaggc
     2701 aattatttat ctacttcagc agatacttca aataataact caaatagtaa ctctgataac
     2761 agttctaata gtaatggtaa taattcttca tcatcaggtc aagtaaatgg tatgtcaggt
     2821 ataagtgggg ctaaaattga ttataaatct ttgagttata ctttagaatc tcatataagt
     2881 aaacaagttg agaaagcagc atcaggagga aatgtgatag ctccaagtaa taggaaaagt
     2941 actccaagtc ctgaatttag tactttttca gctcaaagaa caagctcatt tgtaaatgca
     3001 agttcaagtg atatagaata ttatttaaat cctaagaatt ttacaaatac tactaaaggt
     3061 atgatgcagt ttttaaagat taacagttat agagatggta tttcagaatc aagtcttaac
     3121 tcgtatctta atggtttatc ttctagtgta tttaaaaatc agggagcagc ttttataaat
     3181 gctgccaaga agtataatat agatgttgta tatctagtat ctcatgctat gtgggaaact
     3241 gcttatggta agtctacact tgcccaaggt caaacattaa catcttataa gggacaacct
     3301 cttagtaagc cagttaaagt atacaatttt tttggtatag gagcaataga taaaagcgct
     3361 aatgtttcag gtgcagaagc agcgtattcc aatggctgga ctagtgtaga agctacaata
     3421 gatggctctg caaagtggat atcacaaaat tacgtaaata gttctaagta caatcagaat
     3481 actatctaca agatgaagtg gaattatgat tatacatggc atcagtatgc aactgatgta
     3541 aactgggcta atggaatttc tggaattatg gaaaatttaa ttggtcttta tggaggagga
     3601 agtagtttgg tttttgaagt tcctcaatat aagtaataca taaataaaaa atatagacta
     3661 tgggtagttt tcattttatt taaattatct atagtctttt tgtatataat ttataatctg
     3721 taaattcaat gttaacaaaa cttttatgtt ataatattaa ttctaagtaa atataagtga
     3781 gtaataggta gaaatagata aaaagtggta ataatatata taaagataat tttgagaaag
     3841 gaggatatat atggaaagta ttaaggaata tttggataag ttagaaatta ataatagtgg
     3901 tcttggaaag caacttaaag aagtttatat aaatagagta gtttatttta aggaagataa
     3961 gatagtttat ttttatctaa cttctaaaga tattgtttct catgaacttt tagataaatt
     4021 taaagaagaa ttgatgtata aactcgatta ttttaaagat atgaggatga agataagatt
     4081 tactggtctt gaaagaaaat ccaataaaga tgttataaaa aaatattgga ataatatatt
     4141 gtatatatta aagtatcttt gtccatctat tgcagggtgg tataaacaag tagaatttct
     4201 ttgtttagaa gaagaattaa aaataaaact tccaaaaggt atattttatg agcgattaat
     4261 gaaaaaaaat gtaacttatg tacttaaaac cgtgcttagc gaagagttgg gattagattt
     4321 aaatataaca atagaaaaag ctgttgatga aaaggtaaat aaagaaagac tcataagaat
     4381 caatgataga gaaatggaag aaaaaattag ggctttagaa attggaaaag ttaataactg
     4441 tgaagaaaat gaagaggaaa gctatgtcat taagtctgat gtagatgaaa atttaatcta
     4501 tggagataat gcaaatgcta tgattgaaaa tatagttgaa ttaaatgcat cttctggaac
     4561 agttgcagtt gttggagata tatttgatgt tgacactaaa gaacttaaaa acggaaaaat
     4621 acttatgata gcttcaatta cagattatac tagctcaata agctgtaaac tttttttaac
     4681 agatacaaat aaggatggag tacttgaaaa tgttaaaaaa ggagcatact taaaaatcaa
     4741 gggtgacata gtttatgata catatcaaag agaaattagt atgatgatta gtgggataag
     4801 aaaagaaact agaatagaga gagaagataa atcagaggaa aaaagagtag aactccatgc
     4861 acatacacaa atgtcttcta tggatgctat ttgttctgtt aaaaagcttg tagagcgtgc
     4921 agccaaatgg ggtcattctg ctattgctat aacagaccat ggtgttgtac aaggatttcc
     4981 agatgctatg aatgcaggta agtcaaataa tataaaaata ctttatggag tagaagggta
     5041 cttggttgaa gatgattctc tcattataga ggatgcaaat gataaagaac tttcacagac
     5101 atttgttgta tttgacatag agacaactgg tttttctaat acaaatgata aaataactga
     5161 gattggtgct gtaaaaatag aaaactttaa gattgtagat agatttagtg agttaataaa
     5221 tcctgaaaaa gatatttctt ataagataca ggaattgaca ggaataacta atgaattaat
     5281 taaagacaag ccaaccattg aagaagttct tcctaagttt atggaatttg ttggagatag
     5341 tgtattagta gcacataatg cagagtttga tactggattt atatcgcaaa aatgtaggga
     5401 acaaggcttg ttatataata acaaaaaagt agatacactt atgttagcaa gagtaatgtt
     5461 gccaaactta aaaagacata gattaaatgt cgttgcaaaa gaacttggta ttcctctttt
     5521 aaatcaccat agagcagtgg atgatgctga agctacagca cttatattta ataagttttt
     5581 gcagatgctt acagaaaaag gtgcaaaaac tctaagtgat gtaaacaata tacttggaaa
     5641 gattgattac acaaagctta gcacaaatca tataaccttg atagcaaaaa attctatagg
     5701 tataaaaaat ttatataaaa taatttcaga tgcacatgta aatcattttt ttagagcacc
     5761 aagaatcctt agaagtgtat taaatgaata taaagaagga ttaataattg gttcggcttg
     5821 tgaagctggg gtggtttttc aagctgtaaa gaaaaacgtg tctgatgagg aaatgaaaaa
     5881 aataatagat ttatacgatt atattgaagt aatgcctata gataataata gatttatgat
     5941 tgataaagga gaagtaaagg acgaagaaga gttaagggag ttgaatagga aattaattga
     6001 tacagccaaa aaatttgaca aaattccagt agctactggg gatgttcatt ttttagacaa
     6061 acatgaagct gtcttaagaa aagttcttaa atattctcaa ggttttaaag tagatgaaga
     6121 agaaacttat ttacatttta gaacaacaga tgaaatgttg gaagagttta gttatcttgg
     6181 agaagaattg gcatatgaag ttgtagttga aaatagtaat ctgattgccg atatggttga
     6241 agatataaaa cctataccag atgatactta tcctccaatt atagagggct cagatgtgga
     6301 gttaagagaa atgtgttaca aaaaagccaa acgaatctat ggagacccaa taccagaaat
     6361 agttcaaaaa agactggata gagaattaaa ttcaataata agcaatgggt atgcagttat
     6421 gtatattata gctcaaaaac tggttgcaaa atctctttca gatggatatt tagttggttc
     6481 aagaggctca gttggctcat cttttgcagc tactatgagt gatataacag aagttaatcc
     6541 tcttccagca cattatattt gtgaaaacga agactgtaaa tattcattct tttatgaaat
     6601 aggtgaatgg ggctcaggtg ttgatttacc agacaaggat tgtccaaagt gtggaagaaa
     6661 acttgctaaa aacggtcatg atattccatt tgaggttttc ttaggttttg aaggtgataa
     6721 agaaccagat atagacttaa atttctcagg aaattatcag ccaacaattc ataaatacac
     6781 agaagaacta tttggagagg ggtatgtata tagggctggg actataggta ctgtagcaga
     6841 aaaaacagct tttggatacg caagaaaata tgtggaagaa aataatataa gtgtaccaaa
     6901 tgcagaagta cttaggcttt caaatggatg tactggagta aaaagaacct caggacaaca
     6961 tcctggtgga gttatggtta taccagacta taaagatgta tacgatttta cacctataca
     7021 gtatccagca aatgatactt cttgtggtgt tataactact cactttgatt atcattcaat
     7081 aagtggtaga atacttaaac ttgatatact tggacacgac ggtcctacca ttataaggat
     7141 gcttgaagat atgactggaa taaatataac agaaattcct ttagatgata aagagactat
     7201 gtctctattt acatctacag aagcattagg tgttacacca gaagaaataa actgtcctat
     7261 aggttgcctt gctgtaccag agtttggaac taagtttgta cgacaaatgt tacttgacac
     7321 aaaacctact acatttgcag aacttgtacg tatatctggt ctctctcatg ggacagatgt
     7381 ttgggtaaat aatgcacaag acttagttag agaagatata gttggattaa aagatgttat
     7441 atctacacga gatgacataa tgaactattt aatatttaaa ggattacctc ccaaaatgag
     7501 ctttacaata atggagagtg taagaaaagg taaaggttta aaaccagaac acattgaaga
     7561 aatgaaaaaa aataatgttc cagaatggta tataggctca tgtaaaaaga ttaagtacat
     7621 gttcccaaaa gcacatgctg ttgcttatgt aatgacatca tttagaattg catattgtaa
     7681 agttcactat ccagaagcat tttatgcgac ttattttacg acaaaagttg aggattttga
     7741 tgcagattta attgttaaag gattagatgc tataaaatca aaaataaatg aaattgagtc
     7801 actgggaaat gatgcaacca caaaagaaaa aggtatgttg accgttttag aagttgctct
     7861 tgaaatgtat gctagaggaa taaaattatt accagttgat atatataaat cagatgcaac
     7921 tgagtttata gttgtaggag aaaaaacatt acttccacca atggcagcaa tacaaggtct
     7981 tggaggaaat gcggctataa acatccaaaa tgaaagaaaa aatggtgaat ttatatcaaa
     8041 agaagatttg agaaagagaa caaaaatatc aaaaacggta atagaaactc ttactaatca
     8101 tggttcactt gagaatatga gtgagagaaa tcaattgtca ttgttttaag ttagcccaaa
     8161 aagttgcaaa taaaagaatt ttatgatatc atagtataga aaatagtata ctttgcagaa
     8221 actaagagtg agacagctgt tctcactctt ttattttaaa tatattatta aaaagctggt
     8281 ttatttttat taaatatatt ttatttaaga ttatataaac tggtcattta caattgaata
     8341 ggaggaactt taatgaaaaa aaatttagaa gctacaattg aggagattgt aactaaaata
     8401 acggatgaac atggatttga aatggttgat gttgaatatg taaaagaagc aggagaatac
     8461 tacttaagag tatacataga taaagaagaa ggaatatctt taaatgaatg tgaattagtt
     8521 agtagagaat taagtccaat actagatgaa aaagacccta taaaagaaaa ttacttttta
     8581 gaggtatctt ctccagggct tgatagagca ttaaaaaaag acagagattt tgttagatat
     8641 caaggtagag atgtagattt aaaattatat aaaccattaa atggatgtaa gcaatttgaa
     8701 ggtgaacttg taggattaac agaagataat aatataaaaa tcattgcaaa tggtaaggaa
     8761 atggaattta atagaaaaga tgttgctatt gtcagattag caataaagtt ttagtggtat
     8821 attaaatagg gaggatataa aaaatgaatc atgaatttat ggaagcatta gatgaattag
     8881 tagttgacag aggtatagat aaagaaatac ttatagatac tatagaacaa gctcttttaa
     8941 ctgcatacaa gaaaaacttt ggttcagcac aaaatgttag agttgaattt gatagagaca
     9001 agggagatat aaaagtattt tctcaaagag ttgttgttga tgaatcagat ttatatgata
     9061 ctttcttaga aatagagtta gcagatgcta gagagataaa ccctaattat gaattaggtg
     9121 atattataga acatgaagtt acacctaaaa actttggaag aattgcagct caaacagcaa
     9181 agcaagtagt tgttcaaaga ataagggaag ctgagagaga aatagtgtat aatgaattta
     9241 tagaaaaaga aaatgaaata gttacaggag aggttgctag agcaaataaa aatgttgttt
     9301 atgtaaatct tggaagaata gaaggtataa tgactcaaag tgaacaaata ccatttgaga
     9361 attataaagc aggtcaaaaa ataaaattct atatacttga agttaaaaag actaacaaag
     9421 gacctcaaat agttgtatca agaagtcatc cgggtctagt aaagagattg tttgaagaag
     9481 aagttcctga aatatatgaa ggaatagttc aaataaaatc tgtagcaaga gaagcagggt
     9541 caagaactaa aatggcagta agatctatag atgaaaaaat agacccaatt ggagcttgtg
     9601 ttggaccaaa aggacttaga gtaaaaaata tagtggatga acttggcgat gagaaaatag
     9661 atataataaa atatagtgaa gacccagcag agtttatatc agcagcactt agcccatcaa
     9721 aggttgttag agtagatata gatgaagatg aaaagtctgc cttagtaatc gttccagatt
     9781 atcagttatc gcttgctata ggtaaagaag gtcaaaatgc aagactagca gcaaaattga
     9841 ctaactggaa aatagatatt aagagcgaat ctcaagcaga acaagaaatg ttaaatcttg
     9901 aaaattccaa agaaatagaa gctgaggatg ttgaagctga atttatcgac caagaagagt
     9961 tagatacttc agaggataat tttagtgaag aagagtaagg agggatgatt ttgaaaaaag
    10021 taaaaaaagt gcctcaaaga aaatgcatag catgtcaaga tagagactct aaaaaagagc
    10081 ttataagaat agttaaaaat aaagaaggaa aaatattttt agacccaaca ggaagagcca
    10141 atggaagagg agcatatgta tgtaaaagct ctgaatgtct aaaaaaagct ataaagagta
    10201 aagcattaaa taaagctttt aaaatagatg ttcctgatga agtctatgat aatctactta
    10261 tggagttaga agaatatgaa aaataataaa gaaaaagtac tttcgttctt agggctcgca
    10321 actcgtgcag ggaaaatagt gtctggtgat gattcaactt tgcttgacct taaaaaagga
    10381 aaagtaaatt tgattttaat cgcagaagat gcatcaaata atactaaaaa actttttaaa
    10441 gataaatcaa cttttagaaa tattccatat ctattttttt caacaaaaga ggaaatagga
    10501 tttgcaatag gaaaatctcc aagagcagtt gtaggaataa aagatgaaaa tttttctaaa
    10561 aagataattg aactaataga aatttaaaat aaaatagggg gtgatcttgt gtcaaaaaca
    10621 agagtatacc aaatagcaga agaattaaat atatcaaatg aagagcttat aaataagtta
    10681 gctgaattag atataaatgt aactgacaaa gattcagtat tagaaggtga agagttagaa
    10741 ttagcacttg aaatgttagg tgaagattta tctcaagaaa atggaaatgt tatagaaata
    10801 gatggaaagt tgacagtaca agtattagca acgaaattag ataaatctcc atcagaaata
    10861 attatgaagc ttatgaaaat gggaactatg gcaacaataa atcaagagat aagttttgag
    10921 attgctgctt tggctgccaa agactatgga tttgaattaa cagtagctga aagtgatgat
    10981 acagaagctt tagaaataga agctttaatg gaaattgaag aagataaaga agaggattta
    11041 aaacctagac caccagttgt tacagttatg ggacatgttg accatggtaa gacatcttta
    11101 ctagatgcaa taagaaaaac tgatgtgatt tcaggtgaag ctggaggaat aactcagcat
    11161 ataggtgctt cagaagttaa aatcaatgga cacaaaatag tatttttaga tactccagga
    11221 catgaggctt tcacatcaat gagagcaaga ggagcacaag ttacagatat agcaatatta
    11281 gtagttgcag cagatgatgg tataatgcct caaacagttg aagctataaa ccatgctaaa
    11341 gcagcaggtg tacctttaat agttgctatt aataaaatag ataaaccagg tgcaaaccca
    11401 gataaggtta aacaggaatt agcagaccaa ggattattag ttgaagactg gggtggagaa
    11461 gtaatagcag ttccagtatc agctaagaaa aaagaaggaa tagatacact tttagaaatg
    11521 gtattattgg ttgctgaaat ggaagagtta agagctaatc caaataaaag agcagtagga
    11581 actgttatag aagctgagct tgataaagga agagggccag ttgcaacagt acttgttcaa
    11641 ggtggtactt taacagtagg tgacccaatc gttgcaggtg ttgcatgtgg taaagttaga
    11701 gcaatgataa atgcaaaagg taagagagta aaaacagcag gaccatctac agcagtcgag
    11761 atattaggtc tatcagaagt tccacaagga ggagaccaat ttgtcgaagt tccaactgat
    11821 aagattgcta gaagtgtagc agcaagaaga caacaaatag ttagagatga aatgttaaaa
    11881 tcaactcaaa gattatcact agatgctcta tttagtcaaa tgagtgaagg ttctataaaa
    11941 gaccttaata tagttataaa agcagatgta caaggttcag tacaggcagt taaacaatct
    12001 ttagaaaaat tatcaaatga agaagttcaa gttaaagtaa tacatggtgg tgttggagct
    12061 gtaacagaat cagacatatt acttgcagca gcttctaacg caataataat aggattcaat
    12121 gtaagaccag ttccaggtgc agaatctcta ggagaaaaag aaaatgttga tataagaaca
    12181 tatactataa tatacaaggc aatagaagat atacaagcgg ctatgactgg tatgttagac
    12241 cctgaatatg ttgatgaaga aacaggaaaa gctgaaataa gagaaatata taaaatatct
    12301 ggtgttggaa cagtagctgg atgttatgtg actaatggta agatatttag aaattgtaaa
    12361 gtaagattag ttagagatag cataataata catgaaggtg agcttgcagc acttaagaga
    12421 tttaaagatg atgtaaaaga agttaattct ggatacgaat gtggtatgag ttttgtaaat
    12481 tataacgaca taaaagaagg cgatatagta gaagcttata taactaaaga agtagaaaga
    12541 aaattataaa ttcgtatcaa agaaaatcag ttagtaaaga aggtcgatgg tatggcatca
    12601 tataatagaa caagaaggat agcagaagaa ataagaaaag tcgtaagcac tatgcttata
    12661 aatggagtaa aagaccctag aataacatct atggtgagtg taactgatgt agaagttaca
    12721 aatgacctaa gatatgctta tgtatatgta agcattctag gtggagatga agaatccaca
    12781 ctaacaggtc ttaaaagtgc tggaggatat ataagaagag aagtaggaaa aaatataaaa
    12841 cttagatata ttcctgaaat agtatttaaa cttgatgatt caatagaaaa aggaatgtat
    12901 atggatagcc ttataaaaag agttaatgaa aaaaatgctc aacaaaatga ggatgaaaat
    12961 tatgatgaat aatatggata gtattataaa ctatatttat gagggtgact attttatagt
    13021 tacctctcat atcagtccag atggagacaa tattggttct acactttcaa tgtattatac
    13081 attgaagaat ttaggaaaaa atgtatatta tgtacttgat gatgaagctc cattaaattt
    13141 aaggtttttg gttgaagatg taaaaatcta taagtctaat gaatttaata tgaagaacta
    13201 ttctctaatt gcacttgatt gtggggataa gatgagaata tgtgtgagtg atgaaatcaa
    13261 aaataatgca tcaaaattaa tctgtattga ccatcatgct agtaatgatt catatggaga
    13321 tttaaattat gtagatattg atgcatcttc tacatgtgaa ttagtttata atttattagt
    13381 tagatttcag caaataaaag atattaatat tataaatgaa gatatagcaa catgtttata
    13441 tacaggtctt gtaactgata ctggaaactt ttcgtattca aatgtacatg caagtagctt
    13501 tgaaatggca aaaaatttac ttgttttagg tgcacaaaaa aatactataa tacaaaatat
    13561 atatcaaagc aattcttctg gttattacaa attattagga gaagctctaa agggtttgga
    13621 gatatttgat tcaaaggtat ctagtatagt tttaactcaa gacatgatga atagaaataa
    13681 tattagcttt aatgatgttg atggaataac aacatataca agagacataa aaggtataga
    13741 agttggaatt ttatttaaag agaaaaaaca aaatgaaatt aaagtgagtt ttaggtcaaa
    13801 aaattatgtt gatgtaagtg aaatagccaa gttatttggt ggtggtggtc atgtaagggc
    13861 tgctggatgt actattagag atagtattga taatgcaaag aaaatggtac tagaggcagt
    13921 gttaaaatca atttaaggtg acagtaaaat gaataagatt ataagtatat tgaaacccac
    13981 aggtatgaca tctcatgatg ttgtaagtag agtgagaaag attttaaata taaaaaaagt
    14041 tggtcataca ggtactcttg acccagatgc ttcaggtgtt ttaccaatct gtatagggaa
    14101 agctacaaaa gtatgtgaag ttattttaaa caaagataaa tcgtatatat gtgagcttac
    14161 tttaggtata agtacagata cttatgatgc ttcaggtgaa attttaaaaa aagttgatga
    14221 ttttaaattt agtaatgaag acatagaaag agcttttgac acacaaagag gagagataaa
    14281 tcaacttcct ccaatttatt cagctttaaa ggtaaatgga aagagaatgt gtgatttagt
    14341 aagaagtggt agacaatctg aaattacttt aaaaacaaga agagtaaata taaaagacat
    14401 aaaaatacta agtataaaag gtaataaagt aatgttttat gttgagtgtt ctaaagggac
    14461 ttatgtgaga agtatttgcc atgatatagg agaatatcta ggttgtggag ctcatatgtc
    14521 gtttttgaat agaacatctt ctggtaaatt tgacttagat aattcaataa cattagaaga
    14581 attagaatta ttttatgaaa ataaaacttt agacaaatac ttatatgata tagattatgt
    14641 ccttgattcg tttaattatg ttgtattaaa ccctaatgct ataaaatatt atagtaatgg
    14701 tggctcaata gatgataaaa ggtttttaaa gaataatttc gataaagatg atgaatttgt
    14761 aagagtatac agtacagata atttcttagg attaggaaag ttatcaaaac acaataatac
    14821 aataagtgtt aaaagtgata agatgttcat ataaccaatg tatttaaaaa aacaacaaaa
    14881 gagatagtac tataataact tctatagtct atctctttta cttatgctat aatagtttgt
    14941 gaataagtta agagtaaatt atattttagc ggggaacatt tattatggtg attataaaat
    15001 ctataaaaga aatagcaaac ataaaagaaa gtgtcattac cataggaaat tttgatggtg
    15061 tacacaaagg acatcaagtt cttataggaa aaacagttga acatgcaaaa aaagaaaata
    15121 tacagagtat tgtatttaca tttgcaaatc atcctgtaaa ttactttaga ccaaactcaa
    15181 caaaaaatat tataagcaat gatgataaaa taaaattatt agaagatttg ggaatagata
    15241 tagttgtaat cataccattt gatgagtata tgactaaaat acctgcaaag gatttcgtag
    15301 atgagatact agtaaaaaaa ttaaaagcta aaaagatagt aattggacat gactttacat
    15361 ttgcaagggc aaaagaaggc aatgttaatc tattaaaaag cttagaacat gaatttggtt
    15421 ttgaggtaga agtaataaaa cccatcaaaa tcaatgatgt aagagtgagt agtacttata
    15481 ttagaagttt agtatcccag ggtgatatgg ctaatgtcaa ggaatatttg ggtagaaatt
    15541 acaagttaga aggttgtgtt atacattcta aacaccttgg aagaactata ggattcccaa
    15601 cggcaaatat tgaccttaag aataatatgc tcgttccaaa gagaggtatt tatgcttcta
    15661 ttgtacatat tggagatgag acttattttg gtgctacaaa tgtaggctat aacccaacag
    15721 ttaatggaaa aactttgtct attgaaacaa atattttaga gtttgataga gatatttatg
    15781 gggaaaatat aattgttgaa tttttggaaa gaataagaga tgaaagaaag tttaattcaa
    15841 tagatgactt aaaaaatcaa ttgtataatg atacaaatta tgtgtatgaa aactatgttt
    15901 gcaaaaacaa gtaatgtatg ataaaatgat taaggaaaat aaccattact cggcatttga
    15961 atactccaat caatgcttag taataggcgt ttctaaaaaa atacggaggt aatctaaatg
    16021 ataaacaaat cagaaataat aaaagaatat ggaagagctg aaggggatac tggttctcca
    16081 gaagtacaaa tagctttatt aacagctaga ataaacgagt taaatggaca tttaaaaact
    16141 cataagaaag accaccattc aagaagagga ctattaaaaa tggttggtag aagaagaaac
    16201 ttattagctt acttaaagga aaaagatctt gaaggatata gagcattaat agctaaatta
    16261 ggattaagaa agtaatttca ttctttataa aaaagcaggt atagtgtata cctgcttttt
    16321 tatagttaat tcattataaa gtaaaatagt taataataaa agtagtttat atgttataaa
    16381 aaattataaa atgaataata ttgggtaaga atattaaaat agtatacaaa tacataatca
    16441 atttaaaagg aaagacagga taaatataga aattttataa caggataatt agttggaata
    16501 aggaggatat tattttgaaa ataaagttag tatgcgatag tttgtgcgat attccagatg
    16561 aaatatcaga aaaagattat atagagatag ttccacttac agttattttt aatgataggg
    16621 aatatataga aggagtagat ataaagaaag aagagtttta taaaaaagta aaagaaatca
    16681 agcaaatacc taaaacttca caagctacat atatggagtt taaagaagtg tttgataagt
    16741 tcataacaga aggttatcat ataatctgta tgacaggggc tgcaaacgca tcaggaactt
    16801 ttcaaagtgc tatgatagct aaaaatgatg taaatgaaaa tgaaaaaata catatatttg
    16861 atactagaaa tttatctcta ggtagtggac aatatgttat aaaggcatgt gaacttcttg
    16921 aagaaggact gggatttgaa gaaattatag atgaattaga aaatactcgc agtagtgtaa
    16981 gattgctttt tgcaccatat acacttgatt ttttaaagca gagtggaaga gttccagttg
    17041 caactgcttt gataggaaat atgttaaata taaagcctat atttttcttt gataatgggg
    17101 aagctaagtt ggtaaataag gttagaggaa taaagaatat agcaagtaaa ttggtcgata
    17161 taattttaga aatgaatgaa gggtctttag aaggaaaaat cgtcacaata ggttgtggag
    17221 ataatttaca cgattgtgaa atattaaaag atgaagtaaa taaaagaata aaagcaagaa
    17281 gagtattatt tactcgagga ggagtttcta tttgctctca tacagggcca gatatattgg
    17341 ctataagttg ttctaattag tagtaatata aggtttttgc atatatatgt gaagataatt
    17401 ttatattgtt aatttatagt atttttgata atatagtaaa tagagtgata tacgtgtttt
    17461 ttaataagag gaggacaagc attaatgttt gaacataaaa tatttaaaat ggattttgca
    17521 ggaagagaac tttctgtaga aataggaaag atttgtgaaa tggctagtgg tagttgtata
    17581 gttcgataca gtgatagtat ggtaatggta aatacaacta aatcagccaa acctagagac
    17641 ggaatagact tttttccttt aagtgtggat tatgaagaaa aattatactc tgtaggtaag
    17701 atacctggag gttttttaaa gagagaaggc aagccttcag agaaagctat acttacatca
    17761 agattgatag atagaccaat aagaccttta ttcccaaaag gatttagaaa tgatgttcag
    17821 gtagttgcaa cagttctatc agtagaccaa gattgtacac cagatatagt agcaatgata
    17881 ggttcttcaa tagccctttc tatatcagat ataccattta atggaccaac aggttcagta
    17941 tgtgttggcc ttgtagatgg tgcatttgtt gtaaatccaa acgcagagca aagagaaaaa
    18001 agttcaatgc atctagttgt ttcaggtaca aaggaagcaa taatgatggt tgaagccgga
    18061 gctgatgaag ttccagacga ggtaatgctt gatgctattt tatttgctca ccaagaaata
    18121 aaaaaaatag ttgagtttat agaaggtata gttgcagaag ttggaaaaga aaaaatgcct
    18181 gttgaattat accatgcagg agaagaaata actcaattgg ttcgcgaatt tgcaactgat
    18241 aagatgaaaa aagcagttca gacttttgaa aagttagaga gaatggaaaa tatggataga
    18301 gttaaagaag aaactttagc tcactttgaa gaaactttag aagattttga agattttgtt
    18361 ggagatatag aagaagtatt acaagatata ataaaagaag aagtaagaaa acttatagta
    18421 catgaaaatg taagaccaga taatagaaaa cttgaagaaa taagacctat atggtgtgaa
    18481 actggcatga tacctagagc tcatggttca gccatattta ctagaggaca aactcaagta
    18541 cttaatgttg ctactttagg tgctttagga gatgttcaaa aactagatgg gttagatgaa
    18601 gaagaaaaca agagatatat gcatcattat aatttccctg catatagtgt tggagaagct
    18661 agaccatcaa gaggaccagg aagaagagaa ataggacatg gtgctttagc agaaagagct
    18721 ttattaccag taataccatc tcaagaagaa tttccttatg ctatcagatt agtttctgaa
    18781 gtattaagtt caaatggttc tacatctcaa gcaagtgtat gtggctcaac attatcttta
    18841 cttgatgcag gtgtacctat aaaagatatg gttgcaggta tagcaatggg acttataaag
    18901 catgatggta aggttgcagt gctttcagat atacaaggta tggaagacca tttaggcgat
    18961 atggacttta aagtagctgg aacagagtat ggtataacag caatacaaat ggatataaaa
    19021 attgatggta tagataaaga aattctacaa cgtgctttaa aacaagctaa agagggtaga
    19081 atccatatac taggagagat gagaaaaact atatctcagc caaaaccaga actttcacca
    19141 tatgcaccta agattgttaa aatgcaaata aatcctgaca agataaaaga tgtaatagga
    19201 cctggtggaa agataataac taagataata gacgaaactg gagttaagat agatattgaa
    19261 caaactgggg aagtatttat atcaggtatt gagattgata tgattaagaa agctcaagaa
    19321 cttataaata atatagtagt tgaaccagaa gtaggaaaaa cttataaagg taaggtaagt
    19381 agaataatga actttggagc atttgttgag atacttccag gaaaagaagg attacttcat
    19441 atatctcata tagctcatga aagagttgcc aaagttgaag atgtattgaa tataggggat
    19501 gaagttgaag ttaaagttac agagattgat gaaaaaggaa gagttaattt atcaagaaaa
    19561 gttcttttac caaaaccaga acataaaaat aaataactta ttatataatt aaaagcaaag
    19621 tcttaggatt ttgctttttt aaatacaaaa aagtagataa ttttaaaatg atagttatgg
    19681 atggcttata gttctttttc tgtcaggctt tactcttata aagaagctat ttaaaagctg
    19741 attaatagag agctttattg atatatatag aatcacttaa gttatattta gtgcataaac
    19801 agagcttatt tttaatagta ttaaataaga aacaatttgt acataattag ggggagtttt
    19861 aatgataatg atggtactta ataagagtaa gctcaaaaaa atcataatac taattttagt
    19921 agtgttatta gtattatcag gaggggtaat ggtattaaag ttatttaaca acaagccagt
    19981 atttaattta tttaatggtg tggatttacc atatgaaaga ggtacaaagg ataaaagtgg
    20041 atatgttgca ttaacctgta atatagacct tggatgggaa acagagtacg tagaatccat
    20101 tttagaaaca cttaaaaaag aaaatgtaaa gattacattt aatgtaactg gaaaatgggc
    20161 agaaaagaat aaggatgaat tattaaagat aaaaaaacaa ggacatgaaa taggtaatca
    20221 tggatacaaa catttagatt attctacatt atcatatgaa gacaattatg agcaaataga
    20281 gacctctaaa aagataattg aagaaattat aggtgaaaaa actaaatttt ttcaagcacc
    20341 agcaggttct tttggtccag aaacagtaaa ggctgctaaa gcattagggt atacttctat
    20401 caaatgggat gccgatacta tagattggaa atacaaagac caaccagagg taatcattga
    20461 tagaatgaag aaaaaagaca ttaaagatag tagtataatt ttaatgcatc caaccaatgc
    20521 aacgacaaaa tgtatagatg atattatagc tattgtaaga gaaaaaggac taaaaccagg
    20581 aaaacttagt gatgtattta agtagacaaa gtataaatat ttggttaaga ttgtataagt
    20641 tgtagttgaa ttaattaaaa gactgactta taatgtaata catataaaaa ataaatataa
    20701 ttaaaacata gtgttttcaa taatccaata tgaaacaaag aataaattgt taggagaatg
    20761 taatgtataa gacaaaaata ctggaaaatg ggcttacaat aattggtgaa gaaataccat
    20821 atctaaagtc aataacatta ggtatttgga taaatgcagg ctctaggata gaagaagcac
    20881 aggtgagtgg aacttctcat tttatagagc atatgatgtt taaaggaacc aaaaacagaa
    20941 catcaaaaga gattgctagt tcaatagata atttgggtgg tcaaataaat gcatttacaa
    21001 gtaaagaatg tacatgttat tatgtaaaac taatagatga gcatatagat acaggaattg
    21061 atgtattgag tgatatgata ctaaattcta aatttgataa aaatgatata gataaggaaa
    21121 gacttataat attggaagaa cttaagatgt atgaagactc tccagatgac ttatcttatg
    21181 atttattagt ggaaaatata tatgctaatg atggattagg aatgaatata attgggacaa
    21241 aagaatctct gtacaatata actagagaat ccatgttaga atacttaaat aagtattata
    21301 ttccaaataa cgctgttatt tctatagctg gaaactttaa ctttgatgat atggtggaga
    21361 aaatcaaatc aaaatttgga cactgggaaa agaaaaattt aagtatagac ataagtgagg
    21421 ctaagtttaa tccttgcttt atatcaaaaa ataaagatac tgaacaggtg aacttagcta
    21481 tgtgcctaaa aggtattcct tttgaaaatg atgaagaagt ctattcaatg gcagtggtaa
    21541 ataatatttt cggtggaagt ataagctcaa ggctttttca gaaaataagg gaagaaaaag
    21601 gtttagtata ttcaatatac tcatcacaga cattatatag gaaatgtggt gaattaggta
    21661 tatttgcaag catgagtaca gaaaatttac aagatgtata taatttaata aagaaagaaa
    21721 ttgaaaatat aagagaaaac tatcttacag aaaaagaaat atctgaaagc aaggaacagt
    21781 taaaaggaaa ttatatattg gatttagaaa gtactagcag tagaatgatg tctactggta
    21841 aatctatgtt acttagtaaa aaagtaaaaa ctacagatga aatacttgaa tgtataaata
    21901 atgttaatat taattcaata aagaaggttg ttgataaggt attcaatatc gaaaatattg
    21961 gtacatgtat agttggaaga gatgtagaaa agattctaca cttggattaa tattgaaaaa
    22021 agtaaatctc tggaggtata aaatatgaat ttatctgaaa tagcaggtaa ggaaatagtt
    22081 aacttggtca caggagaaag attgggggtc attggagaat gtgaccttat actagatgaa
    22141 actacaggcg gtatattagc gcttctaatt ccaaaagaaa aaggattttt tgccagaaga
    22201 aaagataagt catttttaga agtaccatgg agaaatgtaa aaaaaatagg taatgacatg
    22261 ataattatag aatatgaggg atatatttag gaggaaaaaa tgagtatttt agtgcaaaag
    22321 tttggtggga catcagtaga atcatatgaa aaaatgaatg aagtatgtaa gatagtaaaa
    22381 gcatacaaaa aaaatgatga agaattacaa ttagtattag tagtttcagc aatgggaaga
    22441 aaaggagctc catatgctac agatacactt ataaatttgt gtagtgcagt aaatgatgag
    22501 ccaagtaaaa gagaacttga tttaataatg tcttgtggag aaataatatc aggaacaatt
    22561 cttgctaatt tattgaatgc acaggggata gattctgttt tctttactgg tcagcaagca
    22621 ggtataatta caagtgatga atattctaat gcaaagataa agtatataaa tcctaaaaag
    22681 gtaaaaagag ctttagatga tggtaaggtt gtagttatag ctgggttcca gggtgtaaca
    22741 gatgatggag aaataactac tcttggaaga ggcggaagcg atacatcagc agttgctatt
    22801 ggtaaagctt tagaatgtga aacagttgaa atttacactg atgtggatgg tataatgact
    22861 gcagacccta gagtagaacc aaacgctaaa gtattgagtt ttatagatta tgaggaagta
    22921 ttccaaatgg ctgacaaagg tgcaaaagta atacatccaa gagcagtaca gttggctaaa
    22981 agtggaaata taactttagc cataaagaat acaatgaatc caacttttga aggtacaaaa
    23041 ataggttctt tatgtagaca cttagaagac aatatagaat atgaacaaga aagagatttt
    23101 aaggttgctg ttgcaaataa agatagcgta gcacaagtta agattaagtc agcagaagaa
    23161 gtgtttacag aagtattaaa tgagatagaa aagaaactta taactataga tatgataaat
    23221 ttctttatat cagaaaaagc atttgttgta gaagatgctg atataaaatc attaaaggaa
    23281 atactagata aatttgaatt agattatgaa gtaaatagag actgtgctaa ggtaacattg
    23341 atatgttcaa gaattgctga tgaaatgtct ggtatcatgt caaaggtagt tagaggatta
    23401 tcaaaagcag gggtatctct tttacaaaca tcagactcaa atatgactat atcttgttta
    23461 gttagtgaag aagatatgca tacagcagta catgctatac accaacaatt ttatttaaaa
    23521 taaactgtat aatacaatta ttttttaatc aaatttaaga atttcatata tatcttaata
    23581 tatttgattt atttggtaaa actaaattaa atataatttt gataggagtt tttttatgaa
    23641 agattataga gaagataatg aaagatttga taaagataat tgtagtgaag aatctagttg
    23701 cgaagagaga gaatgtataa agcaatttgg taccaatgaa atgccacctc aacctcctaa
    23761 agatattcaa tgtataacta taattggaga aattgaggga cattttatag gaaatcctca
    23821 aaaaaaagct acaaagtacg agcatataat tccaatgcta tactcaattg aggaaagtaa
    23881 tgatgttaaa ggagtgttag ttgttttaaa cactgttgga ggagatattg aagcaggttt
    23941 agctattgca gaacttttaa acagtacatc taaaaaagta gttactcttg ttctaggagg
    24001 aagtcatagt ataggtgttc ctcttgctac agcaggagat tactcattta tagcaccaac
    24061 agcaaccatg attatacatc cagtgcgaac tactggtctt gtgattggga taaatgagac
    24121 ttttgagtat tttaaaaaga tgcaagatag aataattcaa tttataataa gaacatcaaa
    24181 tatcaaaaaa gatgtacttg aaaaacttat gcatgaaaaa gatgaacttg taagtgatgt
    24241 tggtagtgta ttaataggaa aagaagctgt ggattatggt cttatagatg aagttggagg
    24301 actaaaagaa gcacttaaaa aattaagaga gcttataaaa gaatctgagg aagaaaaaaa
    24361 taatgattaa aatttgttta aataataaaa tttatgatat aatgatgtaa taaagtagga
    24421 gtgttagtgt taaggcatta gcactttttg ctgtgaaggg gtaaaacttg ctaaaaataa
    24481 ggagtgatat taatggccac gaaaaagaag aaaaaaaaga aggtaaatac cttaagtttt
    24541 aatgcagaat atcataattt aataacaata tttataggtg tatttttatt atatagttta
    24601 aattctaatt ctatgggatg gatacctgtg ttaatgcaaa atctttttaa gggactattt
    24661 ggagggcttt caatagcaat accatttata gtaattataa caggactttt aggatttttt
    24721 gatggaaatg aatatatata taggctaaga aagactaaac tatactacat aattatttta
    24781 tttatatttg tattttatgg attattaaat gcaggaactc ttcctgtaga tagcccacta
    24841 aaaggtaaca tgtttgatga tgttatgaaa ttgggtgtaa gtggacaagg tagtggtttg
    24901 atagcaacaa ctattgcgta ttatatgagt aaaatatttg gtatagcagg tggatggtta
    24961 ataagtatct tcgcacttat actttctgta atgtttatat ttaatatttc tataaaagat
    25021 ttggtgtcaa atgcaaaatc aaaatctaaa gcatctaaag acagcaattt aacgtttaaa
    25081 gataaaattg caaatatgaa aaaatctgca atagatatga tgactgatga agtagatgat
    25141 actactataa ataaaaaacc aggtttcttt aaagggttaa tgtcaaaagg tcttaataat
    25201 gatgatgaag aagatgaata ttttgaagaa gaaaatagtg atggtgtaga tgataaaact
    25261 ataaaaatag ttggatttaa taaggcagaa gatgagtatt tagaaatatt agaaggaact
    25321 caaagtatgc cagagttaga tgttttaaaa gaattacaaa aagctaccaa tgaaaatcca
    25381 gttgtagata ctaaaccaga aaaaaaagtt gatatagcta aacctaattt aaatatagaa
    25441 aaaactcaac ctatgagtat tgtagcagag ccagttaatg aggattattc aaactataaa
    25501 aagcctagca ttgagctttt aaataaagta aataagaagt ctgatgaaaa tggtaaaaag
    25561 aaagtgttga aaaatgcttc tcttttagaa aagacactat cagattttgg agtggaagca
    25621 aaaattaatc aagttacagt tggacctact ataacaagat atgaaataca accaagtcca
    25681 ggagtcaagg taagtaaaat tgtaaattta actgatgata tagctttaag tttagcagct
    25741 aaaagtataa gaattgaagc cccaattcct ggtaaaagtg caattggaat agaagttcca
    25801 aatgaagaag ctcaaatggt tggtgtgaga gaagttctag aaagtgaaga atttaataat
    25861 tttaactctc ctcttgcaat gggacttgga aaagacgtag caggaaaaat tataattgga
    25921 gatataggta agatgccaca cttactaata gctggttcta caggttcagg aaagagtgtg
    25981 tgtgtaaata cattaataag tagtatttta tataaggcaa atcctgatga agtaaaatta
    26041 ctattaatag acccaaaagt agttgaactt gcaaattata atggaatacc acatctattg
    26101 ataccagtag ttactgaccc taaaaaagct gcaaatgctt taaattgggc agttacagag
    26161 atgaatagaa ggtacaaatt atttgcagat gctcaagtaa aagatgtaac aagttataat
    26221 gagaaagcgg aagaaaaact tcctaaaata gtaataataa tagatgagtt agcagattta
    26281 atgatggcaa gtgcaaatga tgtagaagat tatatttgta gattagctca aatggcaaga
    26341 gctgctggaa tgcacttgat tgtagcaact caaagaccat ctgttgacgt tataacaggg
    26401 gtaataaagg ctaatatacc atctagaata gcatttgcag tatcatctca aactgattca
    26461 agaacaatcc ttgatatggg tggtgcagag aagcttctag gtaaaggtga tatgttattc
    26521 tatccacttg gtgcagcaaa accagttaga cttcaagggg cattcatatc agagagtgag
    26581 tcggaaaaag taatcgattt tgtaaaaagt caagttaaag atggaataaa atatgaagaa
    26641 gatataattg aaactatatc taaggttaat acttcaaagg gtagtgatga ggatgagttt
    26701 ttgagtgaag cgatagaatt tgtcgtggaa agtggtcaag catctgcctc tatgctacag
    26761 agaagattta aaataggatt caatagagca gctagactta tagattctat ggaagaaaga
    26821 ggaataattg gagcaagtga gggaagtaaa ccgagaaagg tattaataag caaacaggat
    26881 ttgcagaatt tagaaggtga atagaattgt cagttataaa aatagaaaaa gcacttaagc
    26941 tagataaagt aatatttgta gatgtgagaa ctgaaggaga atatgaagaa gaccatatat
    27001 tgaatgcaat caatatgcct ctttttaaaa ataatgaaca taatgacgtt ggaacaattt
    27061 ataagatgca gggaaaacat gaagcaatac aaaaagggtt tgactatgta tcgtataaat
    27121 taaaggatat atatttacaa gcagcagaac ttgcattaaa ttatgataat attgtcatat
    27181 attgtgcaag aggcggaatg agaagtggca gtatagtaaa tttattatca tcattaggtg
    27241 taaatgtata tcaacttgaa ggtggatata aggcttatag aaattttgta ttagagtatc
    27301 taaggcatgt aatggataca aaaaactttg tatctgttca tggattgact ggtacaggaa
    27361 agactgattt gttacattta ttagatgaaa aaggaataga tgtactggat ttagaaggca
    27421 tagctaaaaa cagtggttct acctttggtt ttataacttt tgataaaaag ccaccttctc
    27481 aaaagaactt tgaaacaaaa ctatttgaaa gtatattttt ttcgaaagag aattatatat
    27541 ttgtcgagag tgaaagcaaa cgagttggaa gtgttacagt tccaaatgaa attttcgagg
    27601 caatgacacg agaaggacat catatattat tagaatgtga tattgaaaat agagttgata
    27661 gactttgtag agattatatt tatgataaag atgaaggtaa tatattgatt ttaaaagaat
    27721 gtataaacaa gtttagaaaa agattgggta ataaagtagt agatgattat attgatttat
    27781 tagaatcagg tgaatataaa gaacttgtaa aaagatatct tttagaatac tacgacccac
    27841 tttatatgca ttcagtagaa aaatataagt atagtaagat tataaatttt aatgatacac
    27901 aaaaagcttt agaagatgtt atagacttat atgagagtat attggaagga gaaagtgaat
    27961 gttaaaaata gcattagaat cattaggatg ctcaaaaaat ttagtagatg cagaaataat
    28021 gatgggaatt ttaaataaca aaggctataa attaattgga gattttgaag aagctgatgt
    28081 aattatagta aatacatgtg gatttataga gtcagctaaa caagaatcta tagatacgat
    28141 aataaacttt gcagagttaa aaaaaactgg caatttaaag ttgttgatag taacagggtg
    28201 tctagcccaa agatattctg aagaattaaa aactgaaatt cctgaaatag atgctatagt
    28261 aggaacagga agctatcaaa atatagataa aatacttaaa gaattaagtg aaatgcataa
    28321 aattgtaagc cttaatgata tagagtttgt atttaatgaa gatttaccaa gatatatatc
    28381 tacacctagc tatatggcct atttaaaaat tggagaagga tgttccaata attgtactta
    28441 ttgtataata ccaaaactaa gaggtaaata tagaagtaga aaatttgaag atataattaa
    28501 agaagctaag aaattagctg aatctggagt aaaagaactt gtggttatag cacaggatac
    28561 gacaaagtac ggttttgatt tatatggaaa agaaagatta tcagaacttt tagaagaact
    28621 tgcaaaaata gatggattta agtggataag ggttatgtat tcatatccag aatctataac
    28681 agaagaattg atacaagtta taaagaaata tgataatata tgtagttact ttgatatgcc
    28741 aatacagcat gcaagtaaca atattttaaa attaatgaat agaaaaacta ctaaagaaga
    28801 tatattaaat aaaatcaatc tgataagaag taatatacca gatgctatac ttagaactac
    28861 aataatagta gggtttcctg gtgaaacaga agatgacttc aaacaacttg tggactttgt
    28921 tgaagaggtt aaatttgata gacttggtgc atttgcatat tcaagagaag aagatacacc
    28981 agcagataga ttgccaaacc atatagatga agaagtaaaa atacaaagaa gagatacttt
    29041 aatgatgatt caacaaaaaa tatctgaaga acttaatgac aaaaagatag gaaaaactta
    29101 tgaggtgtta atagaagaac agatagaaga taatgtatat acaggaagaa cacaaggtga
    29161 tgcagaagaa attgacagta tagtgtatgt aaaaagtgta gacaatcttg aagtaggaga
    29221 atttgtaagt gttcaaataa atgatgcaat ggaatacgat ttaatgggag atgttttata
    29281 tgaacttgcc taacaagtta actttgttta gaatattttt aataccagta tttgttttaa
    29341 ttatgttgct caatatacca aataaatttt taatagcttg tattattttt ataatagctt
    29401 caattactga tgctttagat ggaaaaatag ctagaaaata caatctagtc actgactttg
    29461 gaaaatttat ggacccatta gcagataagt tattggttat ttcagcactt acatgtatga
    29521 tagaagacca tcttgtaagt agttggatgg taattataat agtggctaga gagcttacag
    29581 ttagcatatt aagagctata gctgctgctg atggaaaagt aattgctgct ggaaacagtg
    29641 gaaaacttaa aacgataact caaatggtat ctatagtgtt tttattgtta ggtgctcagt
    29701 ttgaaaatgt attgatatta aatattggtg aaattctcat tcttatagct acactactta
    29761 cattatattc tggatgggaa tatctatata aaaataaaga gctttttatg tcttctaagt
    29821 aaaaaattat gctttaataa ataaaaacta atgattaata aataaaaaat aacaacttaa
    29881 aattttaaaa atgtaaaaaa gggtatacta ttatagtata cctcttttca ttttaagaat
    29941 attttctttt gtgtatataa ttattaataa tggtttataa ataaaatgta atgaataaaa
    30001 atataatcat tagtagcgtt tttaaattga ctaggtttga tttatgttat ataattaata
    30061 tataacaaga gaacaaatgt ttgtagataa atgaagggat ggtatagaga tgagtgtaga
    30121 tcaagaaaaa ttaaaagcgt tgaatgaagc tttaggtaaa attgaaaaag attttggtaa
    30181 aggttcagta atgaaattgg gagaagcaac atctatgtct atagatgtta tatcaacagg
    30241 agcgattggt ttagacatag ctattggtat aggaggtcta cctagaggga gaatagttga
    30301 agtatatggt ccagaatctt ctggtaagac tactgttgcg cttagttgtg tagcatcagc
    30361 tcaaaaagat ggaggaatag ctgcatttat agatgcagaa catgcacttg acccagtata
    30421 tgcaaaagct ttgggtgtgg atgttgataa cctaataata tctcaaccag atacaggtga
    30481 acaggcttta gagatagcag aggcattgat aagaagtgga gcgatagata taatagtaat
    30541 agactcagta gcagcattag ttccaaaggc tgaaatagat ggagatatgg gtgattctca
    30601 tgtaggttta caagctagac ttatgtcaca agcacttaga aagttaactg gttcaattaa
    30661 aaaatcaaat tgtgttgcta tatttataaa ccagttaaga gagaaagtag gaataatgtt
    30721 tggaaaccca gaaactacta ctggaggacg tgcactaaaa ttctattcat cagttagatt
    30781 ggatgttaga aaaatagata caataaaaca aggtgataaa gttataggta gtagaactag
    30841 agttaaagtt gttaaaaaca aagtagcacc accatttaag caagctgaat ttgatataat
    30901 gtatggagaa gggatttcaa aaattggaga ccttttagat atagctgctg atgtagatat
    30961 agttaaaaaa tcaggttcat ggtatagtta caatgatact aaacttggac aaggaagaga
    31021 aaatgttaaa aaattcttgg aagataattt agatttaact actgaaatag atgagaaagt
    31081 tagagcattt tacaatttaa atgaagaaca tgaagaatca ggtacttcag tatcaaaaga
    31141 aattgtagaa gaataagtaa aaatacaaaa aaataactag taattaaaga catgccacgc
    31201 tccctattag cttgacacaa tgttgaaaaa attataaaat taagtgagga taaaatatct
    31261 aaatttaatt ttaattatta ggaatatttt ttaatcatag tgatgacatt ttgggattat
    31321 taacgaagga ggtggatgtc atagatagtg tagtaatgat tgtaataggt gcagctgttg
    31381 gtattatagc tggatatttt gttagaaaaa atatatctga agcaaaaatt ggacaagctg
    31441 aaaacttggc caaagaaata atagataaag cacaccacga ctcagaaaca gtacaaaaag
    31501 aaaaattact agaagctaaa gaagagatcc ataagtggag aacagaagct gaaagagaaa
    31561 acagagaaag aagaacagaa gtacaaaagt atgaaaaaag agtagtacaa aaagaagaag
    31621 tcttagatag aaaattacaa aatttagaat ctaaagaagt aaacctaagt gaaaaattaa
    31681 aggtagtgga aaagaaagaa gaagaagttg aagtaataaa aactcaacag ttagaaaaat
    31741 tagaaagtat atcaggaatt acttctgata aggccaaaga aatcatctta accaatgcgg
    31801 agagagatgt aagacgtgaa atgtctataa tgataaaaga gatagaaagt caagctaaag
    31861 aagaagctga taagaaatca agagaaatta taggatatgc aattcaaaaa tgtgcagcag
    31921 atcacgtagc cgaaactact gtaacagtag taagcttgcc taatgatgaa atgaaaggta
    31981 gaataatagg tagggaaggt agaaatataa ggactttaga aaccttaaca ggtatagacc
    32041 ttataataga tgacactcca gaagccgtaa ttttatcagg atttgatcca ataagaagag
    32101 aaattgcaag aattgctcta gaaaaattaa tagcagatgg aagaatacat ccagctagaa
    32161 ttgaagaaat ggttgaaaag gcgagaaaag aagttgacaa tattataaaa gaatatggtg
    32221 aacaagctgc atttgaaact agtgtacatg ggattcatcc ggaattaata agattattag
    32281 gtagacttaa ctatagaact agttatggac aaaatgtact taaacattct atagaagttg
    32341 ctcatatagc tggtataatg gctgctgaaa taggagcaga tattagattg gctaagaggg
    32401 caggtttatt acatgatata ggtaaggctg tagaccatga aatggaaggt acacatgttg
    32461 aaataggtat ggatttactt agacgttata aagagtctaa agaagttata catgccatga
    32521 gtactcatca tggagattac gagcctcaaa cagtagaggc tgtattagtt acagcagcag
    32581 atgcaatatc agctgctaga cctggtgcga gaagagaaac tttagaagca tatataaaga
    32641 gacttgaaaa attagaagaa atagctaatt catatgaagg tgtagaaaaa tcatttgcta
    32701 tacaagctgg tagagaaata agaataatgg taaaaccaga agctataaat gatgaagaaa
    32761 tacatctatt ggctagagat atgactaaga aaatagagga tgaacttgaa tatcctggac
    32821 aaataaaagt aagcataata agagaaacaa gagctataga gtatgcgaag taaaagaaat
    32881 aatatctaaa taataagaaa atatttttag aaatttaaat ttgccacaag atatgataat
    32941 atatcttgtg gcttttaaat tgtttaagtt taattttata taatgcaaaa ataatctaag
    33001 tgctaaaagt gctacttaca aaagattaat aaaataaagc tttatatatg tattatttat
    33061 ataattatcc aagtttgttt gatataatga agttgtaaaa taaatatatt actacttgga
    33121 atgcttgtac ttaaataaga tgaaaataca atgacgctaa agtgaggatt agagagaggg
    33181 tacactatga aaaaaaatac acttttacat acaaatatta tggtttgcat tattattact
    33241 cttggttttg tggctacctc tataattgga tatcaatcta ataccaatat ttttaaaaat
    33301 gatattgaac atgtatctac attggctgct gaaggtattt attatcagat agataaacta
    33361 ctttcagaac ctataaatgt atctcttaca atggcaaatg acagtctatt aaaaaatttt
    33421 ttagatggtg agaaagaaca tttaaatgat gaagaattta tttataaatt acaagattat
    33481 ctgaatgtgt atagaaataa atattcatat gattctgttt ttttagtatc aactaaaacc
    33541 aataattatt atcattttaa tggacttgat agaaatctta gcgctaataa ctcagagaat
    33601 caatggtatt atactttctt aaagaatgat gatgaatact cattaaatgt tgataatgat
    33661 gaagcaagta acaatagtat tacagtcttt gtaaattgta agataaaaga tgataatgga
    33721 gcaactatgg gaattatagg tgttgggtta aaggttaatt cattacaaat gttgcttaaa
    33781 ggatataatg acaaatttga tgttgttgca cgcttaattg atgataaagg gtttgtacaa
    33841 ttagcagtag ataaaaccgg tcatgagaat ataaattttt ttgaaaattc tagtagcgac
    33901 ttgtctaatt cgaaacaatt aatattaaac aacaaaaagg aacaaaagag tttttggtat
    33961 tcatctgaaa aatcaaaaag ttatattgta tgtcagtaca tacctagttt aaaatggcat
    34021 cttgttctag aaaatgattt tactttaatg attaaacagc ttcatctgca attttttaaa
    34081 ggcattgcag ttatagtttt aattataata tttgtacttt ttactattac acatgtgctt
    34141 aaaaaataca aaaaccaaat aataaagctt agtgtttcac agaaattgga atatcaaaaa
    34201 ttgttgagca aatctactga aggtctttat gaaaatattt ttgaaattga tattactaac
    34261 aataaagctg gttgtgaaga tgagaatagg tattttcatg aatttggatt agggcttaat
    34321 accccatatg atgaagcctt acatacaata gctaaaaacc aaatcaaaga agaatatgca
    34381 caaggttatt tagatacatt tttacctgaa aatgtaatta aacgttataa tagcggaatt
    34441 aataatatca gctatgattt tttaattaaa aaagatgaag aaagttatca ttggattaga
    34501 attaatgcac gaattttctt ttggacatca gatgaatctg ttcgtatgat atcttatcgt
    34561 aaaaatatag atgaagaaaa aaatagagaa ttactacttc tcgaacgttc acaacgtgat
    34621 tctcttacag ggctttacaa taaagctaca acagaggaat ttattcgttc atttttaaaa
    34681 aatgaaagta atcaagattt agaacacgtt tttctaattt tcgatattga taattttaaa
    34741 aatgtaaatg ataaatatgg tcatgtattt ggagactttg ttataagtga atttgcctta
    34801 gaattaaaat ctcaatttcg tgaggacgat attgtgggac gtattggtgg agatgagttt
    34861 gtagtattaa taaaagactt taataataat aactatgtgc ttatagacaa attagagcgt
    34921 ttttgttcta agattaatca gaaaaaattt gttgagcaag cagaattttc tattgcatgt
    34981 agtattggtg tagcaatgta tcctgaacat ggatatgtat actctgaact atatgagaaa
    35041 gcagaccaag cactttacta tgcaaaaagc catgggaaaa attcttatca tatattttca
    35101 gaggattcta ttgatagtat ttcatttcat atagactcta gagatataaa agtattatta
    35161 gaaatggcta ctgatggtgt tgtcaaattt gcttgtatgg aaaacttaaa attactttat
    35221 ttcaaccaaa aaatgcttga atttactgga tattcagctc aaactgttac ttctataggt
    35281 tttgatattt tttcgcctgt attacaagac gacttacaaa tggtactaga tacattaaga
    35341 gaagcaattt ctaaaagaga gacttttgaa atagtttttc gtttttgtca tacagatggt
    35401 catatttttc ctgtaaggat gcaaggtaag tttgtaagtg aattatatca aaatcgttat
    35461 cctgtttttt atgcgattta tacagacata tcaagtatca atactttact agaaaataaa
    35521 tagtaaatac tacagtaaaa tctaaaaata ggatataata gtattaatat aagaagatta
    35581 taaataaaac ctgctaatga aaatagatta tttttagcag gtttttaaat tttttataat
    35641 aaatcttatt tttggctaac aagatttatt ttttttaaga ctttacttat tattttaagc
    35701 attaattatg aaatttatca ttttattatt tacagaaagt attttataac aataaatatc
    35761 tatacttatt gcaaaatttt tttagcagtt ttgtatttat ttgtatttat tttgaattta
    35821 tttactaaat ttgcctataa aaagtatata taaaaatata gttcaaaatg gtataattaa
    35881 gtataacaga aggaggtaat gtaagtgagc caatacataa atataaattc tcagttagac
    35941 gccctaaaat tgaaggagtt cgagaaaata ttttacgaaa atatcaatga ggacgttaaa
    36001 gtagtgccaa aagttactcc ttttaaagga ataaataccg atttgttgta tgttaaagat
    36061 ggaagaattt tatttataaa atttatggat acaacagaag atatattttt tattttagaa
    36121 gaagagttac ttgaagttat gaatgaggaa tatgaacttt tgaaactaaa aatgggacaa
    36181 aagaatagaa atataagtta taactacgtt tacattatgc catacgttga agttgaggaa
    36241 acatatgaat ttgaagaatt tgttaataat aatataatag ataaaaataa gcttcaagat
    36301 ataatgaata agggttcgct ggaggaatat cttaatgatg agaatgatga aataaactta
    36361 aatttatttt tactagacat atgttcagaa tactatataa taaatgataa acttcatcta
    36421 aatgaaaaat ttaaaaaaat ttcattctac aatgatgact ataagtatac agcaactatg
    36481 atggaagacg ttcaaattaa agatgttgtt tctattaaat atgggaatac acttattgaa
    36541 ggtggttctg gtataggcaa aacagcaatt atgctttcta gggctataaa attagcaaaa
    36601 gtatatccac atcataaatt agtcatattt acacatacaa aacaactgtg caatgagctt
    36661 cgagagagga tagagttatt atacaaagat aataacaatt tagaagttca cacatttagt
    36721 tcttttatat ttaaactagc taaaaaattc aatttaattg tagattataa catgttaaaa
    36781 aatgattacg aaaagacctt taataatctt gtaaaacaag cacagaacat tataaaaaat
    36841 aaaaatatgt tcaaggctat ttttattgat gaagcagaaa gctttttaga gtatgaaata
    36901 gattttataa gggagttttt atataaaaca aaattcatat ttaatgtgtg ttcttgtaac
    36961 tccttgaata tctctaatag attgaatata tttaaaaaat tatataatgg tatagaattt
    37021 gatgataaga ttatcttaag taaaaattat agacaagcta aagagattgt agattttaca
    37081 aataaatttt caaataattc taactcatat atcaacgaat taagaccaaa tacagaattt
    37141 agtactttct tttatactaa agcacttaga ggtggaaata agtctgttga tataataaaa
    37201 gtaagtgacc ttgatgacca aataagttct gtaatctggg aaattgagta tttaataagt
    37261 aaaaaaggtc ttgattattc tgaagttgct atcgtttatc cttacaataa gaagaaatta
    37321 aaaagtggaa aaaccattta ctttcaatat atgttaaaaa aagcattgga agaggcaaaa
    37381 attccttata tatgtgcaga agataatttg acaaatataa gtaagaaggt aggaactaca
    37441 atagcaaata tatatgcaat aaagaattta gagtataaag cggtaatagt atgtgaatta
    37501 gagatgttat acaatcaaac tataaatgat attgaacaag attatcaagt aaatgacttt
    37561 gtaggagatt taaataaggt ttatttagct atgagtagag caacagacta cctaagtata
    37621 gtaacaactt ttaatgaaga agcaagtgat ataataagac ttattacaga atcaaaagat
    37681 atttagtaaa aaaatatttg taatttaaga aaataaaaag agactgagat ttgtaaaata
    37741 aactttacca attcagtctc ttatttttta gtctactttc ccaatattat caagaggtaa
    37801 tagtctcacc ataaccttac caagaacttc atcttcatca accataccta catcagggaa
    37861 tctactatca ttactatttt ctctattatc tcccattgca aatagtttac cttttggaac
    37921 aacagtatct atatctccag aagtatagtt attgtgtata tatggttcat ttaataattt
    37981 tccatttaca tacactttag aatttgatat ttttattctg tcaccttcag tagctataac
    38041 tctttttatt aagtcttttt tctttcctgt ttctccatca actaaattgg ttttaaaaac
    38101 tacaatatcg cctttttcag gtttaccaac cttgtatgat atcctattta aaatcagata
    38161 atctttatca tctaaagtag gatacattga ttctccactt acaatagaag gtcttataaa
    38221 ttgtagaatt acaaatgcaa gtacaatagc catagctatt gacttaatcc aatcaaatat
    38281 ttctttttta acactcataa cttttctcct tatcatttgt tattaaatta gaatacatta
    38341 taatagaaag aaataagcaa gaaccactat acccaagact attctataat aaccaaatac
    38401 tttgaagtca tgttttttga tatagtccat aaaaaattta ataactacaa ttgaaacaac
    38461 aaatgctact acagaaccaa cacctaaaat aagccattca aatccagtaa atccaaatcc
    38521 agcttttaga agttttaatg cactagctcc aagcattgta gggatggcta agaagaatga
    38581 aaactctgct gctacatatc tagaagtacc aagtaatact gcacctatta tagtagaacc
    38641 agacctagat gtacctggta taagagctag acactggaat aatcctatac aaagagctaa
    38701 tttatatgta acttgagaaa aatctttata cttaggtttt ttatttctct tttcaagccc
    38761 tatcattatt ataccatata caataagagc aatagcaact actgttgaat taaagaataa
    38821 tctatctata tcatcttcaa acagtattcc aataactcca gatggtataa ctgcaattat
    38881 aaccttaagc cataaacgga ctgtttcttt tttctgctta atattctttg cgctatcaaa
    38941 aggatttaat tttctaaaaa atataacaag tacagctaat attgaaccaa attgaattac
    39001 aactaaaaat gtacttataa atgtatttga aaaattcaat tttataaact catcaactaa
    39061 tatcatatgc cctgtactac ttactggtag ccattctgtt attccctgaa ctatgcccaa
    39121 aatgactgcc ttaaaaattt caagcaaact aaatgtttcc aaatcaaaat acctccaata
    39181 caaatttata gtagcatatt ttattcatag attaataaaa aaatgccacc ttttactaac
    39241 ttataatacc atagtactgt gtagtgcaca atggaagatt gatattttca taaaaccttc
    39301 ataatataac aaaataaact taaaagttat ctattgaata aggggtatat ttgaggggga
    39361 aatatatggt atagtaaaag tatagctatt ttattttatg aaaaggaaag gagttattat
    39421 gtatagtaca aaaatactag atgattatga gtatgaaact tttaatgttt tttctacaaa
    39481 attaaatcca aacacgaaac acgattattt atcaaaggtt atactgttta aagaattttt
    39541 aaaagggaaa gaattgattt atgctacgaa agaagattgt aaaaattttg tagactatat
    39601 acagactaaa tatgcgaaat caacttgtga aaagatatat agttatttac atagttttta
    39661 taacttctta aaaaaagaag gatacataga tataaatcca tttagatatg tagaaaaacc
    39721 cacagtaaca agaataaaaa caaaagatga tgttctaagt atacaagaaa taaataaact
    39781 tataggtatc ctaccaaaat taaatataag agatagagta ataatagtct gtctagttac
    39841 tactgggtgt ttattaaatg aattagttag cttaaagtgg aaagacctta tggtagatga
    39901 aaacgataac tcatatgtaa ggttaggtaa gggaagaaaa gaaagagtag ttaaattaca
    39961 tccatacttt tttaaacttt tagaagatta caggaattat tctgggcttc cagaggtaat
    40021 aatacctagt gatgatttta tttttacaac tcaaaagagt aattctataa cagatagaaa
    40081 tgtcagactt atagtcaaaa aagcattaga tttagctgga ctttctcaat attcagcaag
    40141 agattttaga cattcatttg cagcaataag tttaaggctt ggggcagatg aaagtgatgt
    40201 aaaaaatcag cttggatgga gtgataaata ctatgcaatt agatataagt atgtattaaa
    40261 ttttgttgat agtgaaatag tggattactt aattgaaaaa gataatttgg atataaataa
    40321 aaaatagtaa taaataaaaa atactatata taaatgtgaa caaaaaataa aaaagtcttg
    40381 ttatagttcg taaaattata tataattatt tatgtactaa tgtgtacaca gtaatcacac
    40441 gacaaaagat ttaaggaagg tgctaatata atgatagata ataaatatac tacttactca
    40501 aacccactta cagacagata ttgtagcaag gacatgagtt atatattttc tccacaattt
    40561 aaattctcta catggagaag gttatgggtt gcacttgcag aaggtgaaca tgagttagga
    40621 atcaatataa ctgaagaaca attagatgag ctaagagcta atatagataa tataaatttt
    40681 gatgaagcta gaaaaataga aaaagaagta agacatgatg taatgtctca cgtaaaagct
    40741 tatggtttac aatgtgaaaa agccaaagga ataatacatt taggagcaac atctgcatat
    40801 gttggagata atacagatgt tatacaaatg aatgaagctt taaaacttct aagagtaaag
    40861 cttgtaaatt taataaacaa tttaaaagaa tttgcactta agtacaaaga tatgccagct
    40921 cttggattta cacacttcca agctgctcaa cttacaacag taggaaaaag agcttgttta
    40981 tgggctcaag atttaattct tgatttggaa gatttaaact atagaataga caacatgaag
    41041 ttaagaggag ttaaaggtac tactggtact caagcaagtt ttttaagctt atttgaagga
    41101 gaccacgaaa aagtaaaaga gttagataag aaaatttgta aaaagatggg ataccattct
    41161 tcctatgcag taagtggaca gacatatact agaaagttag attatcaagt aataagcata
    41221 ctatcaggga tagctcaaag tatgcataag atgactaatg atataagact tttacaaagt
    41281 ttaaaagaat tagaagagcc atttgaaaaa aatcaaatag gttcatcagc aatggcttat
    41341 aagaggaatc caatgagaag tgagagaata gcatctttat ctaagtatat aatctctgaa
    41401 tctataagcc ctgcaatggt acaagccact caatggttag agagaacatt agatgactca
    41461 gccaataaga gattggcaat acctcaagca tttatggcag cagatgctat acttgaaata
    41521 gggataaatg taactgatgg tttagtagta tatgaaaata tgataaatag acgtgtaaat
    41581 gaagaacttc cttttatggc tacagaaaca atacttatgg aagctgtaaa aagaggtgga
    41641 gatagacagg aattgcatga aataataaga gaatattcta tgaaagctgc ctatagagta
    41701 aagcatgaag gcaaggataa taacttaatt gaacttataa tgaatgatga ttcatttaaa
    41761 atgagcaagg aagaaatact atctataatg gacccaaaaa actttatagg tagagctcca
    41821 gaacaagttg tagaatttgt aaatgaagtt gtagaacctg ctataaaaga ttataaggaa
    41881 gacttaggaa aagtagatgt agacctaaga gtatagaatt gtacagataa aatataatta
    41941 aaaacggcta tcttatttat aaataagata gccattttaa tgggctagcg tcttctctcc
    42001 accgctgtga agagttcttc tttacttact ataccatgaa tttaataaaa tagctatata
    42061 aataatattt aataggaata atataaataa aaataaaaaa atgataagat tactaattaa
    42121 atttaaacat tcagcaaaaa ctattgtact tgcaatattt ttaatgtaaa ctgaaataaa
    42181 gttatttaga taatttaata aattttaaaa caaccgaggt gattatatga actatatagt
    42241 aaaagatacc ataagttttt tagtaaaaac atttcctaag atttattcta gcctgtactt
    42301 agaagaccta aaaaaatttg caccagatta taatgtaaat aaaacacaat taagagcatt
    42361 agttttcata aaaaattatg gagtaataag tatgactgat ttatgctcta agttaaatat
    42421 agaaaaaggc agtttaacta gtatggttga tgatttaact gataagaagt atgtaacaag
    42481 gaaaagagat ttagttgata gaagaaaata tctaattgac attactgaag agggagataa
    42541 gatagcaact gattttatgg ataaattaag tgatggttta ggagaaaaac tttctaaatt
    42601 aactgaagaa gacagaaaaa aatatttaga agcaataaat actcttcaat atatattaaa
    42661 caaagaagaa tttagataga aaaaatataa aaatttttgt atttaatggt actaagatta
    42721 attctttgtt atttatttaa ctatataatt ataagtctaa atacaatcta aaaagtacat
    42781 cttaaatttt cttgatgtac ttttttataa tttctctaac taaggcaaga caagttttag
    42841 atgctttaat taaagtgaat aaagattact ggccaacact atataaagaa aatgaaaaat
    42901 agtcaggtct aagtcttaat taatatatta attaagaaat gtcccctttt caaataatat
    42961 ctgaaaaggg gacattttat atcattaaat ttatataaat taagtttaaa aaattatttt
    43021 tgtaaagcta catattgctc taaaccttct tttaataatg tagcagctct atgaaggtct
    43081 ttttcattta agatgtaagc taatcttatt tcatcacgtc ctaaacctgg agtagcatag
    43141 aatccttcag cagggcaaac cataactgtt tcattatctt tattaaattc ttttaacatc
    43201 caaattgtga aatcttctgc attttcaact ggtaatttag caactatata gaaagcacca
    43261 gttggttttt tacatataac accttcaacc ttcattaatt cattgtataa tacatctctt
    43321 ctttttttgt actcttcatt aacttctttg aagtaagaaa caggagtttt gtataactca
    43381 acagctccta tttgctctaa tgtaggaaca caaagtcttc cttgacataa tttaagtatt
    43441 tgagcgataa gacctttatt tttgcaagcg atagaaccaa ttctagcacc acaagcactg
    43501 tatctcttag aaacactgtc tattattata actctatcct gtacaccctc taagttacca
    43561 cagcttgtat actcaagccc atcataaaca aattctctat aaacttcgtc tgctattatc
    43621 cataaatctt tttctttagc tatttcagct aggatattaa gttcttcttt tgtataaatt
    43681 gcaccagttg gatttcctgg gttagaaaga attatagcct tagttttatc atctacttta
    43741 gacaatattt cttctttaga tggaaggtgg aaaccgtttt ctgcctttgt tgtaacagca
    43801 ttaacttcta cgtttacaga ttgaccaaat ccattgtagt ttgtatagaa tggttctgga
    43861 actaatagat tatctcctgg gtcacaaact gccatcatag tgaaaagtaa agcttcacta
    43921 ccaccgttag ttactaataa ttcatctttt tcaaaattca tatcgtaagt tttatagtaa
    43981 ttttgaagtg cttctaataa ttctggaata ccttctgatg tagcatattc taagacttcg
    44041 ctatcaaagt ttttaacagc atcaaaaaat cctttaggag tttttatgtc tggttgtcct
    44101 atgtttaagt gatatacttt gattccttta tcttttgctg cttgtgcaaa tggaacaagt
    44161 tttctgattg gagaggcttg cattgcacta actctgtttg aataattcat tttaataccc
    44221 cctatttaat ttaaatacgt atattgtatt atgtaaattg tatgtttgaa tacaagacat
    44281 ctttacaaga taataataac atacttatgg gtaaaaatca tcaaaaaaaa ttaatatagc
    44341 tttaaaataa acttttaaca aattatagta aaatacccat gtttatgcca ctaaattatg
    44401 tattcataaa ttaatttata gtaagataat attctgatgt actgatagtg attttttagt
//
LOCUS       DAEQCW010000020        43319 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.020, whole genome shotgun sequence.
ACCESSION   DAEQCW010000020 DAEQCW010000000
VERSION     DAEQCW010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43319)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43319)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43319
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.020"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(76..2031)
                     /locus_tag="KRO40_001144"
     CDS             complement(76..2031)
                     /locus_tag="KRO40_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091972.1"
                     /translation="MKKYEIFIFMSIIVLCFISFPHKVFGQEENCLEDFERWVQENKN
                     NKEEIVYTLSCDMVIDEEFRFYIPYDSNFTIDTNKYKILIKNHGRFIIDDNELNITGE
                     GGKEGVIHIENGGSISIGINNIIATDGTALYVEEGGDLHIKSSYESVEKIKANGKDAI
                     GIYTENDIRILNKNIEVNGEHAIGVYSKGDVEIEETSIKAYSSNNESGLLKDNNKLAQ
                     SIISESKKVYIIDDYNELIPSIAEDSGYDIVKCCHRGIDVFSDEIKVSKDDKIENIKF
                     PKYMVLETSSGNRLDIDVEWDFTDYYEKLEKGEDFNITGKFKTEMLNKEKIIINDDVV
                     PSLNVSVIEKKPIDNLELEFQNTKNGYVAVLFYDMPYSASKVFVEYSSDGINWISEEQ
                     EDIRDQAILFFEDFKLRCFRVKVVGGLKEGYSNIVFKPGFIMGGGDNQETPDDEREND
                     DIDGDRGGGGRDDPDRDEDDNNQDGNNGNENNDSNNNQNNNNENNNNENDDSDEKQPN
                     TPKDDVESSTDSNENKNPHDIPKDGNKENNSDKEKGFYNKNSITENDDNYDLSSKSVF
                     GTNEHSFPYRESISNKNQDTNKNKSNISDYDGIINNNYKLESKEYNLKKDIIFLFCIL
                     TPIMIGSILIVNPDTRKSIIKFIKLKK"
     gene            complement(2214..3689)
                     /gene="spoIVA"
                     /locus_tag="KRO40_001145"
     CDS             complement(2214..3689)
                     /gene="spoIVA"
                     /locus_tag="KRO40_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage IV sporulation protein A"
                     /protein_id="HBH2091973.1"
                     /translation="MNNNIYEDISKRTQGDIYIGVVGPVRTGKSTFIRKFMEKLVIPN
                     IDNEFKKDRTRDEIPQSGSGKTIMTVEPKFVPADGVEIKIKDTVSLKVRMVDCVGYIV
                     EGALGHEEGGKQRLVSTPWSQEAMTFEKAAEIGTKKVIKDHSTIGIVVLTDGSVTGID
                     RKSYVEPEERVIQELKNLKKPFAVVLNTLSPKSEETSMLRSELEEKYEVPVLPMNVVE
                     MEEEDIEEVMEAVLYDFPLTEIRINLPKWVEGLERNHWIKSSIITTLKQSIIDIGKIR
                     DIEGIIQGFSELEFLEDTGVDNVELGEGVINIDLQTKQDLFYNVLEEKSGFKIEGDYQ
                     LLSLITRLSKVKNEYDKIESALIDAKIKGYGVVAPSLEELSLEEPEIMKQGKQYGIKL
                     KANAPSLHIIKADISTEVSPIVGNQNQGEEMIKYLMEVFEEQPADLWESNMFGKSLHD
                     LVKEQLQSKLYTMPEEIRVKMQKTLQKIVNEGSSNIITILL"
     gene            complement(3861..5155)
                     /locus_tag="KRO40_001146"
                     /pseudo
     CDS             complement(3861..5155)
                     /locus_tag="KRO40_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903280.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
     gene            complement(5339..6748)
                     /locus_tag="KRO40_001147"
     CDS             complement(5339..6748)
                     /locus_tag="KRO40_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2091974.1"
                     /translation="MKKKIGFWDLVFMNISALFGIRWIAKSTASSFGLGLGSIPVWLL
                     FAFIFFVPASLICAELAATYPKDGGLGEWVKQAYGEKWGFMVSWLNWTSKIFWYSSFL
                     TFLAINIAYMLGNPDLSNNKMFILALSLIIFWLLSLVSTRGMAFGKFFTNTGALGSTI
                     PAILLIVMAFMSVVILKKAPSASIYTIQNIIPKIDANSLVSISAIIFALSGAETTANF
                     ITEMDNAKKNFPKAILTVAVLIGGIYILGSVAITMILPPDKIAASTGILDALAKVAQD
                     LGIGSWFIRIVAFGITLSVLGALILYIAGPVKMLFGNVREGVFPKQLTVTNKYNIPSN
                     AVIVQAIIVSLLLVGTNLLPSVDNIYNVLVTMTALTALFPYVLLFTSYIRLRKTRPNE
                     ERPYSIAKSDSVCINIARMVLVVTVVGILFSTAPVMETLKDNIIYEIEMIGGGLFVII
                     TGLMLWKNYEKKISNNSGC"
     gene            complement(6800..7939)
                     /locus_tag="KRO40_001148"
     CDS             complement(6800..7939)
                     /locus_tag="KRO40_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2091975.1"
                     /translation="MSNNMRLERLRKYMNEKSIEIALIFEPDNQFYISGFKAITYSRP
                     IVTVVTQDKIELIVPGLEELHAKEVAKVDNVYVYYEIPEMKEHGISHKHYLDIILNKY
                     PKGTTVGIEKDIVSASFSEYITDKSFAIKDVGSKIFEMRYVKDAKEIEFLKIAGYLSD
                     IGIKGSLENVRVGMSELEFDVAGDNALLKYVSENYPDTYIGFANWTCSGIDRTAQPHL
                     DSNTRILQRGDIVIHSRQVWYENYRAENERTFIIGKPTERQKEVFKIAVEAQQAGLDT
                     IKAGIPARMVDEAARAVVAKYGLELYSNHRIGHGLGLSEHEEPYLRFDNELILEEGMV
                     FSMEPGIYIPGVGGFRHSDTAIVGKNGATIITNYPRSVEELILDI"
     gene            8258..8908
                     /locus_tag="KRO40_001149"
     CDS             8258..8908
                     /locus_tag="KRO40_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2091976.1"
                     /translation="MTNKELQKKRILMYFIEAAQNIMENEGIENITLRKVADMAGYNS
                     STLYKYFKNLDHLISFASIKYFKDYNLNISRCIENVNDEYKKYIIMWKLFCKHSFDNA
                     QAFYQVFFNLSSDELSYITKQYYDMFPEDLGIHDSDISLMITGESIKERNKILLNNLV
                     DTGYIPAKDLDIINDIIISFYQNLLFLKKNTGKNSDDDELTMKMISSIEYIIKHAK"
     gene            complement(9065..10084)
                     /locus_tag="KRO40_001150"
     CDS             complement(9065..10084)
                     /locus_tag="KRO40_001150"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HBH2091977.1"
                     /translation="MEKVCVLGTGSWGSALALGLAKKGNDVSMWTRKEEQAKKINRTK
                     ENTDYLPGVLFPNNITISTDIEKTIKDCKVIVLAVPSQAVRSTCQKIKPFIKEGQVIV
                     NVAKGLEKGTGLRLSQVCEEELPQNPYVILSGPSHAEEVARDIPTTVVVASKDLKIAQ
                     MIQDLFMSPKLRVYTNPDIVGVELGGALKNIIAFGAGICDGLGYGDNAKAALMTRGIS
                     EMSRLGIAMGANMSTFAGLSGIGDLIVTCTSMHSRNRRAGILIGKGMSLEDTLKEVKM
                     VVEGITATEVAHDVAEKLDIDMPITNAIYSVIKKGSNPKEVGIELMMRSKKHEMEEVV
                     LGDDI"
     gene            complement(10115..10729)
                     /gene="plsY"
                     /locus_tag="KRO40_001151"
     CDS             complement(10115..10729)
                     /gene="plsY"
                     /locus_tag="KRO40_001151"
                     /EC_number="2.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HBH2091978.1"
                     /translation="MEIFSYIIIAVVAYLLGNISTSYIVAKRIAGVDIRTQGSGNAGS
                     TNVLRTLGKRAGAMTFLGDVLKGVMAVLISEFAARLVGIDTLLAGYLAVICVVAGHNW
                     PAVLGFRGGKGVATSLGAMLAVNPVITLMCLAVFILVVAITKYVSLGSVVGIGCSPIF
                     MIMVKNKAGLIVALFLTASVIYNHRANIKRLLNGTERKIGQKKE"
     gene            complement(10764..12083)
                     /gene="der"
                     /locus_tag="KRO40_001152"
     CDS             complement(10764..12083)
                     /gene="der"
                     /locus_tag="KRO40_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HBH2091979.1"
                     /translation="MSRPVVAVVGRPNVGKSTIFNKFAGKRISIVENTPGVTRDRIFA
                     EVEWLDKYFTLVDTGGIEPDSEDIILSQMRNQAMLAMDMSHVILFIVDGKAGITAADK
                     EIAQLLRKTKKPVILVVNKIDSQSQFDNIYDFYELGFGTPFAVSGANSMGFGDLLDEI
                     VENFPAGLDTEYEEDIIRVAITGKPNAGKSSILNKILGEERVIVSPIAGTTRDAIDTY
                     FEKNGQKFLLIDTAGLRRKSKIYETIEKYSVIRAMSAVDRADVVLIVIDALEGVTEQD
                     TKVAGIAHDEGKGCIFVINKWDLIEKDNKTMSNYTKDIKEKFPFMMYAPIVFVSAKTN
                     QRMNKILDTVEYVSNEHSKRISTSALNEVIGEAVMLNQPPSDKGRRLKIYYGTQTDIR
                     PPKITLFINDKDLTHFSYQRYLENKIRENFGFEGTSIKFEYRQKNKK"
     gene            complement(12117..13445)
                     /locus_tag="KRO40_001153"
     CDS             complement(12117..13445)
                     /locus_tag="KRO40_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF512 domain-containing protein"
                     /protein_id="HBH2091980.1"
                     /translation="MEVNVKKVNNIISKVYKDSIAEEMGIEVGDLLISVNEQPIHDII
                     EYRFLLSDEYLDVEIQKKDGEVYIYEIEKDYDEDLGVEFTNPIIDQAKSCRNKCMFCF
                     IDQLPEGMRETLYFKDDDSRLSFLQGNFVTLTNMSEEDINNIIKYRISPINISVHTTN
                     PELRQKMISNKFAGKLYGIMKRLADAHIEMNCQIVLCPGINDGKELDRTIKELAQLYP
                     YVNSVAIVPVGITKHRENLVELNIFNDKSASKTIEQIHQIQQKYLEKLGTRFAFLSDE
                     FYILSNSELPGYEEYEGFLQFEDGVGMIRKLKTEIEEYLNILPEKILKREKKVSIATG
                     HSAYEFIQSMADAMMDKFKNLQVNVYEIKNKFFGETITVSGLLTAKDLKEQLEDKELG
                     EALYITRSMLKADEEIFLDNIELNQLEELMRIKIIPCLNEGKDFVDKILK"
     gene            complement(13683..13883)
                     /locus_tag="KRO40_001154"
     CDS             complement(13683..13883)
                     /locus_tag="KRO40_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2091981.1"
                     /translation="MGMDIGLNEYTLAIVTLDKNMKNGGGCPIFYANDEKDLQNKALL
                     MSKCVGGMVHDMTNGTLIIVKH"
     gene            complement(13885..14817)
                     /locus_tag="KRO40_001155"
     CDS             complement(13885..14817)
                     /locus_tag="KRO40_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426964.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBH2091982.1"
                     /translation="MDRVFFVAVIIGITSRIIMLNLDQKQYPTQPNVLLSQLILAFVA
                     SSLGALLVPALINRSYTSITFLSLAAEQFRQVRANRRNTLQNLEEVQLVKRGAAFIEE
                     IARTYEVRNYMCIVTSFLTIGLYYVILAETKISEGMSLVISSICGLVLAFILKKLLTR
                     KSIGDIADVMPAEISFVDESILKVGDLKGITNIGLKSDREVYINRGVGIQIIPKNKDY
                     ANAGILFDSGQRQAIVYNIYSRLGLYGDYGEPSFVPLPRRNKEDESIMIAYLPVDKNV
                     EKVMEAVKSCPILSSSKGKNLSLKNYKIGKKGSA"
     gene            complement(14862..15794)
                     /locus_tag="KRO40_001156"
     CDS             complement(14862..15794)
                     /locus_tag="KRO40_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBH2091983.1"
                     /translation="MEESLLNANLFRHSFIVALVVGILCRGLVLRVTDKQYPSRPQDY
                     LEQIIISGLSASLGAIALPALIDKEFAALTFFAVAIQQFQGLAEQERITLKNIDNEEL
                     VPKGDAYVEEIASTYESRSYISLFSALVSSIVYIVFARKYGLSFFYCTILAIVSGAIV
                     GLIFRRFLRRNSIADIADIVPAKISFEGPILMVNGVIITNIGLESTREKYRNECLAIE
                     VIPRDLGAFGIVNDIGQRQAIIHNLFIHMGIDRDVDEVDIVAISKTNLEKSTVVIPYM
                     PILKDIDVMIDVVKSTPIIETSKGKQSDFSRKTL"
     gene            complement(15849..17138)
                     /locus_tag="KRO40_001157"
     CDS             complement(15849..17138)
                     /locus_tag="KRO40_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2091984.1"
                     /translation="MEDLNSIYFFIVMLSIAIVILAVRYTITLRKYLKEFIYVSKKVS
                     NNEYHARLNISAKGELGELARNFNHMIKNMDKTLEEVQYKHLQLRSILKSISHGILAI
                     DVNGNILLINDEAKEMIKSEPNQLVEGHNINVVIKEEEILKQILQFIGSKDNETANIT
                     TKDDIVYKIKVDPVYLQNTNNVIIGSIVNIEDITKKVKLENMRSDFVANVSHELKTPL
                     TSISGFVETLKSNENIDVNTRNRFLEIIESESDRLKRLIDDILLLSFVENKDTLLMEN
                     VVVYDVFKEVYEITQHSASEKNIEVLYKCDDKSISILSNKDYIKQVFLNLVDNAIKYT
                     QDNGIVQVVVLKDEEKIVIKVIDNGVGIPKEDVERIFERFYRVDKARSRDVGGTGLGL
                     AITKHIVKSLNGCIKVKSELGIGSEFIVTILQKNFLK"
     gene            complement(17167..17859)
                     /locus_tag="KRO40_001158"
     CDS             complement(17167..17859)
                     /locus_tag="KRO40_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2091985.1"
                     /translation="MNTKVLVIDDEMHIVELLKFNLEVSNYEVSYSYDGFDGFIKAKE
                     IKPDLILLDWMLPNISGIEVLRKIRSDKDLKNIPVIMLTAKNMENDKVEGLEIGADDY
                     ITKPFSIKELLARISSVLRRYNLTSLGEENNILTTGNLKLDLSKHEVTKGSEKIELTL
                     KEFELLKLLIQNKGKVLSRNYLLDKIWGYEYYGETRTVDVHIRYLRKKIEDEDKSEKY
                     IETIRGVGYKID"
     gene            complement(17874..18635)
                     /gene="pgeF"
                     /locus_tag="KRO40_001159"
     CDS             complement(17874..18635)
                     /gene="pgeF"
                     /locus_tag="KRO40_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan editing factor PgeF"
                     /protein_id="HBH2091986.1"
                     /translation="MMKDYINIKNVQDIKEYVNLSGNCEELDEKLNSVNLVITCKNID
                     AKNREDMLKVCKECDLTFENLTSNSQIHSDIVTIVNKDTIGKRRDGDALITNLEKVPL
                     LLFTADCVPISIIDAKNKAIGLAHAGWRGTFSNIGHKTIKLMSECYKTVPEDLVCIIG
                     PSIGPCCYEVSEDLVEKFNTILTNNDEKFYIIKEGSYYLDLWKINEYMLRCSGVKKEN
                     IINLNLCTSCRADKFHSYRKHNKASERIGTVLQIK"
     gene            complement(18632..19093)
                     /gene="nrdR"
                     /locus_tag="KRO40_001160"
     CDS             complement(18632..19093)
                     /gene="nrdR"
                     /locus_tag="KRO40_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HBH2091987.1"
                     /translation="MQCPYCNYKESKVIDSRHTDLKSIRRRRECESCKKRFTTYEKIE
                     TTPLMVIKKDNSREYFDREKIKYGLLKACEKRPVSIDEIESIVVHIENEINKCFIEEI
                     ETKKIGEMVMDKLKELDEVAYVRFASVYRQFKDINTFVNELKSILIEKGDK"
     gene            complement(19115..19378)
                     /locus_tag="KRO40_001161"
     CDS             complement(19115..19378)
                     /locus_tag="KRO40_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBH2091988.1"
                     /translation="MIRVSDIMEKEIINVKNGKRMGFIIDIDMDIHEGKVVSFTIFGD
                     GSRSFFSRGGDEEVIFWNDILKIGCDTIIVNIGSELSLDEFEI"
     gene            complement(19482..20255)
                     /gene="sigG"
                     /locus_tag="KRO40_001162"
     CDS             complement(19482..20255)
                     /gene="sigG"
                     /locus_tag="KRO40_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="HBH2091989.1"
                     /translation="MQVNKVEICGVNTSELPVLKNKQMKELLLQIKNGDEEARQQFVR
                     GNLRLVLSVIKKFNNRGENIDDLFQIGCIGLIKAIDNFDLSQNVRFSTYAVPMIIGEI
                     RRYLRDNNPIRVSRSLKDIAYKALQVRERLIRTNSKEPTVSEIAKELELEVESVVMAL
                     DAIQDPISLFDPVYQDNGDAIFVMDQVQDKKDTDENWLQEISLKEAIKKLNSREKLVL
                     DLRFYKGRTQIEVADEIGISQAQVSRIEKNALKNMRKYV"
     gene            complement(20347..21069)
                     /gene="sigE"
                     /locus_tag="KRO40_001163"
     CDS             complement(20347..21069)
                     /gene="sigE"
                     /locus_tag="KRO40_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigE"
                     /protein_id="HBH2091990.1"
                     /translation="MLRLKERIISFITMLGIKLKIIKPKGIYYMGGANILPPPLKPEE
                     EMELLQKLETDESVKSILIERNLRLVVYISRKFENTGIDVEDLISIGTIGLIKAVNTF
                     KLNKNIKLATYASRCIENEILMYLRKNNKKKTEVSFDEPLNIDLDGNELLLSDVLGTE
                     NDEIYKIIEEEIDRDLLVMALDRLSDREKQIMELRFGLIDKGIEKTQKEVAGILGISQ
                     SYISRLEKKIISRLQKEMKKFV"
     gene            complement(21094..21966)
                     /locus_tag="KRO40_001164"
     CDS             complement(21094..21966)
                     /locus_tag="KRO40_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-E processing peptidase SpoIIGA"
                     /protein_id="HBH2091991.1"
                     /translation="MFKGFKGGYMVYIEYYVIENLVINYIIISCTSILTKRYNPKKNK
                     LLGASLGGAYSVAYLYPSMNILFTVPFKIIIMSIITLISFRSKSKKDYVHVALVFYLV
                     NIFISGSTYFIIYFTGISHLKISFLIACTYVSCELLKYIYKDLKMLKYIKELTKTINI
                     NLLEKSFCCKALVDSGNLLKDPISQSDVIIVKSSVLEGFIPEKLLNINYEDIDMKKAQ
                     EIIGSLDDKTSGRVRIIPYKHAGSNKTSIIIGLKADYIEVDEQKIGNIILGISNFNDR
                     EYGAIMNPNILPGF"
     gene            complement(22256..23530)
                     /locus_tag="KRO40_001165"
     CDS             complement(22256..23530)
                     /locus_tag="KRO40_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH2091992.1"
                     /translation="MIKLKKVLSLVMVGILSVSILAGCSKKEDSKGKEGKEKLVVWSA
                     PLTDHDADAWKPIFEKFEKENNCEIEFQIVPWDNYAEKYATAISAGEGPDIGYMYAEM
                     FPQFIEMGAVEDLTPYLEKSGTSDNYLYLDDAKMMGGIYGLPIEAANPGVLYYNKDIL
                     EKLGEKPPKTWDDFKRICEKATKDTDGDGKIDQWGLAQGWGSKVFGSLNWNWYPYLWQ
                     AGGDIYNDDLKSVKFNNAEGLKAANFINDMKKYIPEDALSKDSNEMIESVFGPGKAAF
                     TIMLSSAATSTFDKSFPDLNWGYVTSLEDKTVGSFASVDDLTLMSACKNKELGFKLLE
                     YMLSKESMEAFHKEIPRAPVAKGEKYQGDPRFEEMVTRDKHMYRPLTVGPHGVEIYEY
                     LWKQLQMMIAGDITPEQALNESAKYANGLLAQ"
     gene            complement(23814..24971)
                     /gene="ftsZ"
                     /locus_tag="KRO40_001166"
     CDS             complement(23814..24971)
                     /gene="ftsZ"
                     /locus_tag="KRO40_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HBH2091993.1"
                     /translation="MLNFDVELEECAQIKVIGVGGGGNNAVNRMVEAQLKGVEFISVN
                     TDKQALYTSKAEYKVQIGEKLTRGLGAGANPEVGKRAAEESKDEIVKLLQGADMVFVT
                     AGMGGGTGTGAAPVVAGLAKEMGILTVGVVTKPFAFEGKIRMKNAEGGIAELKSKVDT
                     LITIPNDRLLQIVQKNTSMLDAFAVADDVLKQGIQSISDLIAVEGLINLDFADVTTIM
                     KDKGLAHMGIGSASGETRAIDAARQAIQSPLLETSIQGAKGVLLNVTGGPNLGLFEVN
                     EASTLVMESCDPEANVIFGASIKEDLGDEIMITVIATGFEGLQNGALDLDTKPKSSIR
                     SSLNTTVKQAVKEIEEEVIAEEKIEPPKKASIIEEDDDESMEIPTFLRRRR"
     gene            complement(25161..25514)
                     /locus_tag="KRO40_001167"
     CDS             complement(25161..25514)
                     /locus_tag="KRO40_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small basic family protein"
                     /protein_id="HBH2091994.1"
                     /translation="MLWVLGGLAFGVVVGYYIPFTYSMDYSIYMSVAILAIMDSIFGA
                     IKSNFEDNYDNVIFITGFIGNAILAILLTYIGEKLGVSLYYVAVLVFGMRLFNNLSII
                     RRYIISNIMNKKRKN"
     gene            complement(25613..26287)
                     /locus_tag="KRO40_001168"
     CDS             complement(25613..26287)
                     /locus_tag="KRO40_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH2091995.1"
                     /translation="MKKKIVILGAFILGVFISTYIKSLDPNRVYITLGQTESIESEVE
                     NTKKEIKNLKETLKKNKKTLNEYKEAKKNGNESIQTLMQKELEEVKELSGYSTVTGPG
                     ITITMRDSERELKDGQNPNDLIIHDIDILRVLNDLKKAGARAISINGERVLATSKIKC
                     SGATITVNDTTYGQPFIIKAIGDIDLLSAAINSPESYAKSLKDIYGINIKVQENNGNK
                     VNLFAK"
     gene            complement(26292..26990)
                     /locus_tag="KRO40_001169"
     CDS             complement(26292..26990)
                     /locus_tag="KRO40_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH2091996.1"
                     /translation="MKKRFINKSIIIGSIVLGVLVSLQLKIINIENRGMTTFKRGEQL
                     TEELKSLKKEKENLQSEVNSVKKDIETYRGKNNEGEQDILKSEIEKYETLAGYTDVEG
                     TGIKIEINSTKDLGNSDKNDSILYNYDLLLSMINKLNSAQASAISINDQRIVSNTYMY
                     LKEDKLYMNDTVIKEPIIIKAIGDSDTLASALNIKYGIVWEIETYYNAKVKVTKEDNI
                     EINGHSDINKAEGK"
     gene            complement(27013..27753)
                     /locus_tag="KRO40_001170"
     CDS             complement(27013..27753)
                     /locus_tag="KRO40_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsQ-type POTRA domain-containing protein"
                     /protein_id="HBH2091997.1"
                     /translation="MKKRRKLNTNNVMIVLVFILMLSFCICIIVKSDLFDVKKIDVIG
                     NKRVTKSNIMKELNVNLNENIFAYNFKDMKNKLIKNPYIENVEIKRKLPNKIIISLKE
                     KEIFAVLKDEDNYCYIDKKGNLLEELRGSNESKKDLIVDVDYSIDDNKSIKFKNYKTK
                     ENVFKTLNYLKEEGIYRKINYVNLKKESNIEMLTRSNIKILLSNDDNLDYNISRVSKI
                     LIDLQNKNTNGGTINLNYGKLAVYSPEG"
     gene            complement(28023..29249)
                     /gene="murG"
                     /locus_tag="KRO40_001171"
     CDS             complement(28023..29249)
                     /gene="murG"
                     /locus_tag="KRO40_001171"
                     /EC_number="2.4.1.227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBH2091998.1"
                     /translation="MKVLLSGGGTGGHVYPAIAIANKIRDEHPDAEIIFVGTEKGIES
                     EIVPKYGFELKTVTVQGFKRKIDFDNVKRVFKLFKGLEQSRKIVKKFKPDIVIGTGGY
                     VSGPVLFNASMGKIPAIIHEQNSFPGVTNKILSKTVTKVLTSFEDSHKRFPEAAEDKL
                     VFTGNPVRKEILLSRKNIARKNLSISDEKRMVLCYGGSGGSRKINDAMRLVIKNMVNE
                     DIAFIFATGKSYYDEFMGSISDINLKPYQKVVPYLEDMANALAASDLVIGSAGAISLA
                     EITALGKPSIIIPKAYTAENHQEYNAKSIEKQGAGIAILEKNLTPESLNTAVFKLLGD
                     RELLVDMANASKTIGKPEAIDLIYDEIMKVYNSTQKSASKKTKKEKVIKEVKEIKKET
                     TPSIEGQAKVIGIKKR"
     gene            complement(29267..30397)
                     /gene="spoVE"
                     /locus_tag="KRO40_001172"
     CDS             complement(29267..30397)
                     /gene="spoVE"
                     /locus_tag="KRO40_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein E"
                     /protein_id="HBH2091999.1"
                     /translation="MPKENLKKQIDIRMKTEFDGVVFYTTMLLVFVGIVMVFSASFIQ
                     SSFKHNDAYYFLKKNVIYAVLGFIVMIITSRIDYSFWKKNATAIGAIAVVLLLLVLTP
                     LGIEANGAKRWLGIGALTFQPAEIAKFATIILTAKLIEKNYDKIKSLTKGVVPLLVVP
                     GIFFALIILQPNLSTAGTVILVTFVMIFVAGMDMKIVFAMIGSGAALFAALVIAEPYR
                     LSRVTSFLDPFQDPLGKGYQVIQGLYALGSGGLFGLGLGKSKQKYFYIPEPQNDFIFA
                     IIGEELGLIGCIIVIMLFVVLVYRCVRIALKTSNVFACMVVIGIGAQIGIQAALNIAV
                     ATSSMPATGVALPFISYGGTSLTIFMGAVGIVLNISKHVKIN"
     gene            complement(30449..31804)
                     /locus_tag="KRO40_001173"
     CDS             complement(30449..31804)
                     /locus_tag="KRO40_001173"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HBH2092000.1"
                     /translation="MDLKGKKVLLVGLAKTGISTIKHLDKLGASIIVNDIKDENKLRN
                     ILDELKSINDIKYILGHHPEDVDDIDMVVVSPGVPLDLPFILKLKNSGKYIIGEVELA
                     FKLSNNPIFIGITGTNGKTTTTSLVGEIFSRAKRDTYVVGNIGNPVIDTIETSSEESV
                     LVTELSSFQLESIDEFRPKVSAILNITEDHLNRHHTMEKYIEAKANIFMNQTVEDFCV
                     LNYDDEIVKSLADKCNAKVIYFSRTKKVNGGVYLENNDIIIDIDDKIKFLNKDDVSLP
                     GGHNLENCMAAIAIAYVCKIDLEVIKDVLMTFKGVEHRQEFVRNLDNVIYVNDSKGTN
                     PDSTIKAIQSYDRPIILIAGGMDKGSNFDELLETAKSYVKSLVLLGETASNIENCAKN
                     KGFNDIHIVKDMEEAVKTSYEISKSGDIVLLSPACASWDMYESFEVRGKDFKDNVNNL
                     K"
     gene            complement(31823..32791)
                     /locus_tag="KRO40_001174"
     CDS             complement(31823..32791)
                     /locus_tag="KRO40_001174"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HBH2092001.1"
                     /translation="MMLGITELTYTALIAFLIVIIIGPIFIPMLRKFKFGQTVRDDGP
                     QTHLAKNGTPTMGGIIMIVAILITGLTRVKVSHDMAVGLICIAGFGFIGFLDDFIKIK
                     LKRSLGLKAYQKIILQVALSFYVAFYQYTSSSSASQLMIPFTDFVINVGILYIPIMMF
                     IIVAIVNAVNLTDGLDGLASGVTLIVSVFFMLFASSIAGNTEVAVLAAATVGACLGFL
                     GFNSYPARVFMGDTGSMALGGAVVAFSVLTNSVLIIPIIGGIYFAEALSVLIQVGYFK
                     ATRKRFFKMAPIHHHFEQCGWPETRVVFIFWIITVVLAWISIIAVF"
     gene            complement(32832..34205)
                     /locus_tag="KRO40_001175"
     CDS             complement(32832..34205)
                     /locus_tag="KRO40_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HBH2092002.1"
                     /translation="MECLTIKELVLATNGKLIYGDYNDCVSDIVIDSREANAQNAFVA
                     IVGENLDGHTFMKSAYDSGCKTFIKNESNGIKLESSDINLIEVKDTSLALGDISKYYK
                     EKFDIPFIGVTGSVGKTTTRDMIYSAISAKLNILKNEKNLNNHFGVPLTLFNLNKEHE
                     CAVIEMGMSGFNEIKYLVDIVNPKIAVISNIGLSHVEKLGSQEGILKAKMEITSNFDE
                     TNTLIVNGDDKFLSTLKEKEHVYKLKTFGFNKNNDVYCESYTMEEDSLTFICVINGKK
                     EEIFIPTIGEHNIYNAMSAILVGLCLNISLDYIKKGLKNFKGTKMRLDIIKNEKLTII
                     NDSYNASPDSMDAALKILGRYKGRRVAILGDILEMGEISEYGHRLVGKSSMNNTDIII
                     TIGENSVFIGEEAKQLGFNSANIYHFENREDVFNKLNELVKTGDTILVKGSRGMRLEK
                     IVEYLNK"
     gene            complement(34372..36351)
                     /locus_tag="KRO40_001176"
     CDS             complement(34372..36351)
                     /locus_tag="KRO40_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein D"
                     /protein_id="HBH2092003.1"
                     /translation="MRKVKRISKKRLVLVLILACALFFCLVIRTGYLQLMKGNWLSTK
                     ALEQQTRDIPIEPKRGTIYDRNMKELAVSVTKYTVWCKPVEVEDKKEAAEKVAEILDE
                     DYKDIYALISKKNMALVKVKRWIDDDKASQIRDAKLSGIWVAEDNQRYYPYGNFAPYV
                     LGHTSSDATGISGVEMQYDKKLKGKPGKLIVSTDASGREIPQGMEKYYEPVQGNGLVL
                     SIDEVIQHYTEKAVQKAYELNNAKKVTAIAMNPKTGDILALASKPDYDPNDSRTPIYP
                     YYQEELEKYNDKDKIKGYYQMWRNPAVSDTYEPGSTFKLITSSSALEEGVIKDGEKFT
                     CTGSVTVGGRKIKCWRHYRPHGTQEFKQAVQNSCNPVFVELGSRLGVGKMYDYIESFG
                     LMDKTGIDLPGEAKGILYNEKNVGPVELATISFGQSISVTPIQLITAISSIANGGDLM
                     QPRVVKSYTDNKGNITETVKPKKVRSVISKETSKKMLEIAESVVTEGGGKIAYIPGYR
                     LGGKTGTAQKVIDGKYAPGKYICSFVGIAPCDDPQIVVLAIVDEPTGVSAFGSTTAGP
                     IVKEIMNDSLKYLGVKPVYKEEEKAEYEKKQVKVPDVRNLKIGDAVKALEDAKLKPDL
                     DADIELPEDTKVKDIFPKPGVKVNEDSSITLYFEN"
     gene            complement(36363..36710)
                     /locus_tag="KRO40_001177"
     CDS             complement(36363..36710)
                     /locus_tag="KRO40_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092004.1"
                     /translation="MKKNYKIHNLNEYKNKKKNNYKKRNKKKIGAKCILLIATFSVII
                     LNLCGYSKISEMKYDIYYLQKDLRKKEIVLEELKAKETEKTSIKEIELKAKELLNMDY
                     PKDGQIKYIDVDN"
     gene            complement(37191..38126)
                     /gene="rsmH"
                     /locus_tag="KRO40_001178"
     CDS             complement(37191..38126)
                     /gene="rsmH"
                     /locus_tag="KRO40_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HBH2092005.1"
                     /translation="MEFHHVSVLLNECIENLNIKPDGVYVDCTMGGAGHSKEIVKKLS
                     DKGLFIGFDQDKNAISTAKERLSEYESRVKFVHSNFENIKEELEKIGVYKIDGVLADL
                     GVSSHQLDEADRGFSYMQDAPLDMRMDVRCEFSAYDVVNTYTEDELTKIIKDYGEDNW
                     AKRIAKFIVEERANKPIETTGELVDVIKKAIPKKARIDGPHPAKRTFQAIRIEVNNEL
                     GVITKMINDASSIMNEGGRICIITFHSLEDRIVKNAFKHLASDCICPQHLPICQCDKE
                     SEVKIITRKPILPSEEEIEVNPRSRSAKLRVAEKI"
     gene            complement(38156..38902)
                     /locus_tag="KRO40_001179"
     CDS             complement(38156..38902)
                     /locus_tag="KRO40_001179"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HBH2092006.1"
                     /translation="MDRVAFTLFGIDIMWYGILMACGMILGTLIAIKEAKRVGIKEDD
                     VLNIAIIAIPVGLICARIYYVVFNWSYYAQNMSQIFNFRGGGLAIHGGLIGGILAGYI
                     YTKIKNINFLKMADTVILGMPLAQAIGRWGNFINGEAHGGATNLPWGIMVDGVKVHPT
                     FLYESIWDFGIFIVLLLFRKNKKYEGQVIVTYITLYSIGRFFIEGLRTDSLMLGPLRM
                     AQVISLIGVIGGIIAHVYLSKKNKNNISEE"
     gene            complement(39296..40582)
                     /locus_tag="KRO40_001180"
     CDS             complement(39296..40582)
                     /locus_tag="KRO40_001180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH2092007.1"
                     /translation="MEKIVNDILKEEVYYEKLQNGLDVYFMPKRGFMKKYAILATNYG
                     SNDLEFVPIGEDKKIRVNEGIAHFLEHKMFEQPDGGDAFDKFSKLGVNANAFTNFTMT
                     AYLFSATENFYESLEHLIDYVQTPYFTDENVEKEKGIIAQEIKMYNDDPDWNVYFNCL
                     KAMYVNYPARIDIAGTVDSIYKITKEELYKCYNTFYNPGNMALFVVGDLDVEKVIDVT
                     KKSNNYKVDRLSKSIERFYPEEPESVKEKEVIEKFPISMPMFNIGFKDSNVGLKGKEL
                     LRKEIVTDILVGMLFKKGSKLYEDLYMQGLINENFGAGFSSQVDYAFSIIAGDSKEPK
                     KVKEIILDYIEKSKKEGLSKEEFERTKKKKIGSFIKCFDSINFIGNSFISYVFKDINL
                     LDYLDVIKDITFEEVEERLKEHFKEEYCVISIVEPK"
     gene            complement(40597..41862)
                     /locus_tag="KRO40_001181"
     CDS             complement(40597..41862)
                     /locus_tag="KRO40_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBH2092008.1"
                     /translation="MVNTKKIINLGNNINLTLIKTEKFKSNLISLYVQRLLDEKETTK
                     NALIPSIIASGSAKYPSARAISNKLDDLYGSSMGADAVKRGERQVLSFKVINISEKYL
                     DESIFEEVVEFFNEVINNTLVVDGGFKEEYLNIEKENLREKIQSIINDKKEYAQDKCI
                     EAMCKGERYSVSEFGYEDEIDSITSRELYEHYKNILKTSPIDIVVEGNFDEDKVVDII
                     SKNLKFEREEIINIPRADFIKNVDEVKVIDEQMEITQGKLVMGYRANVDYADIDKYYA
                     LVVGSNVLGGGPHSKLFVNVREKESLCYYIFSSIEKYKSIMFISSGIETKDYDKAVEL
                     IKKQVESVKAGDISDEELENSKLALVNSMKSITDNIGGMSDFVFSQSMAKTNSEVQDI
                     ISSIEKVTKKDIVEAIKNIELDTVYFLRN"
     gene            42178..43275
                     /gene="ychF"
                     /locus_tag="KRO40_001182"
     CDS             42178..43275
                     /gene="ychF"
                     /locus_tag="KRO40_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HBH2092009.1"
                     /translation="MKLGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGVVSV
                     PDERLNKLQELYNSEKIVPTAIEFCDIAGLVRGASKGEGLGNKFLSHIREVDAIVHVV
                     RCFEDENVVHVDGSVDPLRDIETINLELIFSDIEILERRINKTQKAAKADKTLGSELD
                     LLKSIMSTLEESKCVRTMEFTEDEQTFVNSLDLLTSKPVIYASNVSEDDLADNGENNK
                     YVQQVKAFAETEDAEVVVVCAQIEAEISELDSAEEKKEFLETLGLEQSGLDKLIKSSY
                     ALLGLISFLTAGPKEVRAWTIKVGSKAPQAGGKIHSDIERGFIRAETIAFNDLVEHGT
                     MAAAKEKGLVKLEGKEYIVKDGDVILFRFNV"
BASE COUNT        13503 a         7963 c         4550 g        17303 t
ORIGIN      
        1 taaatacagt tttcataata atgaaaggta ttacttagca atctcatgat tttctaaata
       61 atacctttct aaaaattatt tttttaattt tatgaattta attatacttt ttctagtatc
      121 aggatttaca attaatatag aaccaatcat aattggtgtt agtatacaaa ataaaaaaat
      181 aatatctttt tttagattat attctttaga ttctaattta taattattat ttattattcc
      241 atcataatca cttatatttg acttattttt atttgtatct tgatttttgt tagaaatact
      301 ttccctataa ggaaaagaat gttcattggt accaaatact gattttgagc ttaaatcata
      361 attatcatca ttttctgtaa ttgaattttt attgtaaaat cctttttctt tatcagaatt
      421 attttcttta ttaccgtctt taggtatatc atgaggattt ttattttcat tgctatcagt
      481 acttgattct acatcatctt taggagtatt tggttgtttc tcatcagaat catcattttc
      541 attattatta ttttcattat tattgttttg attgttatta ctatcattat tttcatttcc
      601 attattccca tcttgattgt tatcatcctc atctctatcc gggtcgtctc tacctcctcc
      661 tccacggtca ccatcaatat catcattttc ccgttcatca tctggcgtct cttggttgtc
      721 tccgcctccc attataaatc ctggtttaaa aactatattt gaataccctt cttttaatcc
      781 tcctacaact tttactctaa aacaacgcaa cttaaaatct tcaaaaaaaa gtatagcttg
      841 atctctaata tcctcctgct cttcagatat ccaattgatt ccatcgcttg aatattcaac
      901 aaaaacctta cttgcactat acggcatatc ataaaataaa acagctacat atccattttt
      961 tgtattttga aattccagtt ccaaattgtc tattggtttt ttctctataa cagatacatt
     1021 caaactagga actacatcat catttattat aattttttct ttatttaaca tttctgtttt
     1081 aaactttcct gttatattaa aatcttctcc cttttccaac ttttcataat aatcagtaaa
     1141 atcccattct acatctatat caagtcgatt accactagat gtttctaata ccatatattt
     1201 gggaaatttt atattttcta ttttatcatc tttacttact tttatttcat cactaaatac
     1261 atcaattccc ctatgacaac atttcacaat atcatagcca gaatcttcag ctatagaggg
     1321 tataagctca ttataatcat caattatata aactttctta ctttctgata taattgattg
     1381 tgccaactta ttattatctt ttagtaaccc actttcattg ttgctactat atgcttttat
     1441 tgaagtttct tctatctcaa catcaccttt agaataaaca cctatagcat gttctccatt
     1501 cacttcaata ttcttattta gtattctaat atcattttca gtataaattc ctattgcatc
     1561 ttttccattt gcctttattt tttcaacaga ttcgtaggat gatttaatat gtaagtctcc
     1621 tccttcttca acgtataagg ctgtcccatc agtagcaatt atgttgttta taccaatact
     1681 tatacttcca ccattttcta tatgtattac tccttctttt cctccttcac ctgttatatt
     1741 caattcatta tcatcaataa taaatctccc atgatttttt atcaatattt tatatttgtt
     1801 ggtatctatt gtaaaattac tgtcataagg aatataaaat ctaaactctt catctattac
     1861 catatcacaa gaaagagtat aaactatttc ttctttatta tttttatttt cttgaaccca
     1921 cctttcaaaa tcttcaagac aattttcctc ttgtccaaaa actttatgtg gaaaacttat
     1981 aaaacacaaa actattatac tcataaaaat aaatatctca tactttttca tcttacactc
     2041 ctagaaattt ttagctttga aacaatcctg tcgaaacata tacttcaccc actataattt
     2101 ttccacaatt atcaattatt gtcaatttat ataagtatgt ttattaattg ttataaataa
     2161 aaagctactt actaaagcaa acagacgttt cactttaata agtagctata tttttataac
     2221 aaaatagtta taatattaga acttccttca tttacaattt tttgtaaagt cttttgcatt
     2281 ttaactctta tctcttctgg catagtatat aatttacttt gtaattgctc ttttactaag
     2341 tcatgtagtg acttaccaaa catatttgat tcccataaat ctgctggttg ctcttcaaat
     2401 acttccataa gatattttat catctcttca ccttgatttt gatttccaac tattggagaa
     2461 acctctgtag atatatctgc ttttataata tgaagtgatg gtgcattggc ttttaacttg
     2521 ataccatatt gttttccttg tttcattatt tctggttctt ccagactaag ttcttctaag
     2581 gaaggagcta ctactccata tccttttatc ttggcatcta ttaaagcact ttctatttta
     2641 tcatactcat ttttaacttt agatagtcta gttatcagac taagcagttg ataatctcct
     2701 tcaattttaa atccactttt ttcttcaagg acattataga ataaatcttg ctttgtctgt
     2761 aaatcaatat ttataacacc ttctcctagc tctacattat caacacctgt atcttccaaa
     2821 aactctagct cagaaaatcc ttgtataata ccttctatat cccttatttt acctatatct
     2881 ataatacttt gttttaatgt tgttattatg ctacttttta tccaatgatt tctttcaaga
     2941 ccttcaaccc attttggtaa gttgattctt atttctgtaa gtggaaaatc atataataca
     3001 gcttccataa cctcctctat atcttcttct tccatttcaa ccacattcat tggaagaact
     3061 ggaacttcat acttttcttc caattcactt ctaagcatac tcgtttcctc actttttgga
     3121 cttaacgtat ttaaaaccac tgcaaatggt tttttaagat ttttcaattc ttgtataact
     3181 ctctcttctg gttctacata gctttttctg tcaattccag taactgaacc atctgtcaag
     3241 acaactatcc ctattgtaga atggtctttt ataacttttt tagttcctat ctctgctgcc
     3301 ttttcaaatg tcatagcttc ttgtgaccaa ggagtggata ctaatctttg ttttccacct
     3361 tcctcatgcc ctaaagctcc ttcaactatg tatccaacac aatctaccat tcttactttt
     3421 aaagatactg tgtcttttat ttttatttct acaccatctg ctggtacaaa ttttggttct
     3481 actgtcatta tcgttttacc tgaaccactt tggggtatct catctcttgt tctatccttt
     3541 ttaaattcat tgtctatatt aggtataacc aacttttcca taaattttct tataaaagtt
     3601 gattttcctg ttcttacagg tccaactact ccaatatata tatccccctg agtccttttg
     3661 gatatatctt cgtatatgtt attattcata ttattcctcc tatacatcta atcttattaa
     3721 attatattta gagttaaggg ttaatattct taaaatagaa aaataaagac cagcaatatt
     3781 aatttaattt acatatagaa atttgtaaat ttcaatgtaa attaaattaa tattgctggt
     3841 ccaaatagta gtgtattata ttaactgact ttagtagtat tttcatttga attattattc
     3901 atctcaataa gttctttacg tctttctttt gtcatgttca tccatataaa tgtaaacacc
     3961 aatccaatta tggctactat agtaagaact atgaagtagt acctatatcc agttacaccc
     4021 ggaaatgcat ccaatatctt ccctgctgct aaaggacaaa gtacttctgg aagatatcct
     4081 aatgtagcaa ctattcctat agcagttcct gatattgata atgaataatt accttcttca
     4141 agtaacgaat agtgtaaacc ttgaattgca tacatagata catatattgc aacacatcca
     4201 atcaatagta tataaatcat agatgatttt gttggtgtaa atattacacc taaaagacct
     4261 gcaatcataa gtataaatcc ataagatata atctttgatg aaccaacttt atctccaagt
     4321 aatccagaag cagctgatgc tactggtcta caatactgag ctaatattga gattgcagat
     4381 gcaaacacca cagtagctcc aaatgattca gttgaataag gcgtaaaata ataaaatgac
     4441 atattagctg aatatgaaca aaacattatt attgttatta tccatgtatg aggcattttt
     4501 attactgcaa aaaaggcttc tttatcaaat tttgctgata cctctttttc attatccttt
     4561 aatttgaaaa atactaatac tccaactatt acatttattg cgagtataat actataatag
     4621 ctgtaagacc agatttatca cttacttttg atgaaatata cccaaatagt atcaatacta
     4681 gagatagatg aattgcattg gtaattccac gaccactttc cataaatcca aaagcttttc
     4741 cttgttcatt ttcagatgct aacattctaa cagcttttac aagagctggc caaaaagtaa
     4801 gtattgttgt tattccccat aaggcatgga ttaaaaacac aacaatatat ggaggataaa
     4861 gtgttaatac aagaccagat attcctgtaa taattaaaga acctgaaagc aattttctgg
     4921 ctgaaatacg gtctgctaaa aaaccaccaa aaaggtatga taccattgca agtagaccat
     4981 aaatacttcc taagcttccc atttgtgtat ttgtaagatt aaatgcttgt gcaaaagtat
     5041 cataataata attctttaaa tatggtaaag catatataaa tgctcctgct acaaagagta
     5101 ttatcaagac tttgaaattt ttccaaatgc ttggtttatt tacttcaact gacatacttc
     5161 ctccttatgt aaatacctgt aaattttcat aataattaat tattgcttat tttattgttt
     5221 attcaatatt taggaatatt tattaatata ttaggttaat ctatcaataa tttatggtga
     5281 gttatgagct aaaagtaaac tcttttagct caccataata attatatttt tatttatact
     5341 aacatccaga gttattagat atcttttttt catagttctt ccatagcatt aaacctgtta
     5401 ttataacaaa aagacctcct cctatcattt caatctcata gattatatta tcttttaaag
     5461 tctccataac tggtgccgtt gagaaaagta tgccaactac agttactaca agtaccattc
     5521 tggcaatatt gatacaaact gaatcacttt ttgcaattga atatggtctt tcttcatttg
     5581 gtcttgtctt tctaagtcta atataagatg taaaaagcaa gacatatgga aataatgctg
     5641 ttaatgctgt catagtaaca agaacattgt atatattatc tactgatggt aataagtttg
     5701 ttcctacaag aagtagactc actattatag cctgaactat tactgcattt gatggtatat
     5761 tgtatttatt tgtaacagtc aattgcttag gaaatacacc ttctcttaca tttccaaaaa
     5821 gcatctttac tggacctgct atataaagta ttaatgctcc tagtactgat aaagttattc
     5881 caaatgctac tattcttata aaccaacttc ctatacctaa atcttgtgca actttagcta
     5941 atgcatctag tatccctgta gatgctgcaa ttttatctgg aggaagtatc attgttattg
     6001 ctactgaacc taagatatag attcctccta ttaaaacagc cacagttaat atagctttag
     6061 gaaagttttt cttagcatta tccatttcgg ttatgaaatt agcagtcgtt tcagctcctg
     6121 ataatgcaaa tattatagca gatatagaaa ctaatgaatt ggcatctatt tttggtatta
     6181 tattttggat tgtatatatc gatgctgatg gagctttttt gagaataact acagacataa
     6241 atgccatcac tataagtaat atagcaggaa ttgtagaacc taatgctcct gtattcgtaa
     6301 aaaattttcc aaatgccatc ccacgagtac ttactaagga caacagccaa aatattatga
     6361 gtgaaagtgc taaaataaac atcttattgt ttgataaatc tggatttcca agcatatatg
     6421 caatatttat cgctaaaaaa gtcaagaaag aagaatacca aaatatcttt gatgtccaat
     6481 ttagccatga caccataaat ccccacttct ctccataagc ttgtttaacc cattctccaa
     6541 gtccaccatc ttttggatat gttgcagcca actctgcaca tataagtgat gcaggaacaa
     6601 agaatataaa agcaaacaat aaccaaactg gtatagaacc aagacccaat ccaaaactag
     6661 aggcagtaga tttagctatc catctaatcc caaatagtgc tgatatattc ataaatacta
     6721 aatcccaaaa tccaattttc tttttcactg taattcctcc aatttcaaat ttattcagac
     6781 tcatacacaa tgtattgact taaatatcaa gtataagttc ttcaacactt cttggataat
     6841 tagttataat tgtagcacca ttcttaccta ctattgctgt atctgagtgt ctaaatcctc
     6901 caactccagg tatatatatc cctggctcca tagaaaatac cattccttct tctaatatta
     6961 attcattgtc aaatcttaaa tatggctctt catgttctga taaacctaaa ccatgaccaa
     7021 ttctatgatt tgaatataac tctagaccat actttgcaac aacagctctt gctgcttcat
     7081 ccaccattct tgctggtata ccagctttta ttgtatctaa tccagcttgt tgagcctcta
     7141 ctgcaatctt aaacacttct ttttgtcttt ctgttggttt gcctataata aaagttcttt
     7201 cattttctgc tctatagttt tcataccaaa cctgtctact atgtattact atatctcctc
     7261 tttgaagtat tctagtattg gaatctaaat gaggttgtgc tgttctatca atccctgaac
     7321 aagtccagtt tgcaaatcct atatatgtat caggataatt ttcagaaaca tattttagta
     7381 aagcattatc ccctgcaacg tcaaactcca attcactcat cccaactcta acattttcta
     7441 aagacccttt tattcctata tcagataggt aacctgctat cttcaaaaat tctatttctt
     7501 ttgcatcttt tacatatctc atttcaaata ttttacttcc aacatctttg atagcaaatg
     7561 acttatcagt tatatactct gaaaagcttg cagatactat atctttttct attccaacag
     7621 ttgttccttt agggtattta tttaaaatta tatctaagta atgtttatgt gatattccat
     7681 gttctttcat ttctggtatt tcataataca catatacatt atcaactttt gcaacttctt
     7741 tagcatgtaa ttcttctaat ccaggtacta ttaattctat tttatcttga gttactactg
     7801 ttacaattgg tctagaataa gttattgctt taaatccact aatataaaat tgattgtctg
     7861 gttcaaatat taaagcaatt tcaatgcttt tttcattcat gtactttctc aatctttcta
     7921 gtctcatatt atttgacata atgcacctct ttcttaatat tcagataatt tattcaatac
     7981 aacaaggatg aatatattat tttaaaattc ttaatatttt tagtacttgt cgtatttgta
     8041 tgtaaattaa ttttatttgt gattatttta tcataatcat gattattttg tcaatcatga
     8101 ttttatttta aaaaattttt tatattctag tgattttaaa ttatctaaaa tataacgagt
     8161 atacattgta ttttgtaata ttattcttga tttatggtaa gtttaatgat aaaatcacga
     8221 ttatataaac tatattgatt atttgtaggt gaataaaatg acaaataaag aattacaaaa
     8281 gaaaaggata ttgatgtatt tcatagaagc tgctcaaaat attatggaaa acgaaggtat
     8341 agaaaatatt acacttcgta aggttgcaga tatggctggc tataatagtt caactctata
     8401 taaatacttt aaaaatttag accatttaat atcatttgca tctataaaat attttaaaga
     8461 ttataacttg aatatttcaa gatgtataga aaatgtcaat gatgaatata agaaatatat
     8521 aattatgtgg aaattatttt gtaagcattc ttttgataat gctcaagctt tttaccaggt
     8581 attttttaac ttgtctagtg atgaacttag ctatataaca aaacaatatt atgatatgtt
     8641 tccagaagat ttaggtattc atgatagtga catatcttta atgattacag gagaaagtat
     8701 aaaggaaaga aataagatac tattaaacaa tcttgtagat actggatata taccagctaa
     8761 agatttagac ataatcaatg atataattat ttctttttat caaaatctat tattcttaaa
     8821 aaagaacaca ggaaaaaatt ctgatgatga tgaattaact atgaaaatga tttcttctat
     8881 tgaatacata ataaaacatg ctaaataaaa ttaaaatatg gctgtctcaa aatagagata
     8941 agcctttttt attgttgaaa taataaaaat atatttaatt tcatataaaa aagagtgcct
     9001 cgtaaactaa aaagttcatt ttgagacacc cctaaaataa atttattatt tattatacaa
     9061 tagtttatat atcatcacct aaaactactt cttccatttc atgcttttta cttctcatca
     9121 ttagttctat tccaacttct ttaggatttg aacctttctt tattacagaa tatatagcat
     9181 tagttatagg catatctata tctaattttt cagcaacatc atgtgctact tcagtagcag
     9241 ttatgccttc tacaaccatc tttacttctt ttaaagtatc ttctaaactc atccctttac
     9301 ctatgagtat accagctctt ctatttctac tatgcatact tgtacaagta actattaaat
     9361 ctccaatacc tgaaagacct gcaaaggtag acatattagc tcccatagca attccaagtc
     9421 tgctcatttc actaatacct cttgtcataa gggcagcttt tgcattatca ccatacccta
     9481 atccgtcaca tatcccagct ccaaatgcta taatattttt taatgctcct ccaagttcta
     9541 ctccaactat gtctggattc gtataaactc taagtttagg gctcataaat aaatcttgta
     9601 tcatctgtgc tatttttaaa tctttagaag caactactac ggtagtagga atatcccttg
     9661 ctacttcttc agcatgagat ggcccagata gtattacata tggattttgt ggtaattctt
     9721 cttcacagac ttgagataat ctaagcccag tccctttttc aagaccttta gctacattaa
     9781 caataacttg tccttctttt ataaatggtt ttattttttg gcaagtactt cttacagcct
     9841 gtgatggaac tgctaaaact attaccttac aatcttttat agttttttct atatcagtac
     9901 ttatagttat attatttgga aataatactc ctggtaaata gtctgtattt tctttagttc
     9961 tgtttatttt tttagcttgt tcctcttttc gagtccacat gctcacatca ttaccttttt
    10021 ttgcaagccc taaagctaat gcacttcccc agcttccagt acctaataca catactttct
    10081 ccatgtttaa caccacctga gtataatata tttactattc tttcttttga ccaatttttc
    10141 tctctgtccc atttaataat cgctttatat ttgctctgtg attatatatt actgatgcag
    10201 ttaagaacag agctactatt aaaccagctt tattttttac cataatcata aatattggtg
    10261 aacatcctat tcctacaaca gaacccaatg aaacatactt tgttatagct accaccaata
    10321 taaatactgc tagacacatt agtgttatta ctggatttac agctagcatt gcccctagtg
    10381 aagttgcaac acctttgcct cctctaaatc ctaaaaccgc tggccaatta tgacctgcta
    10441 caacacatat aactgccaga tatccagcta aaagagtatc tattccaacc aatcttgctg
    10501 caaattctga tattaaaaca gccattacac ctttaagaac atcacctaaa aatgtcattg
    10561 ctcctgctct ttttccaagt gtcctaagta catttgtcga acctgcatta ccagaacctt
    10621 gagtccttat atcaacccca gcaattcgct ttgcaactat gtatgaggta gatatatttc
    10681 ctaaaagata tgcaactaca gcaataatta tataactaaa tatctccact gaatttcccc
    10741 cctttagtta tattttaaga tatttatttt ttattttttt gtctatactc aaactttatg
    10801 gaagttcctt caaatccaaa attttctctt atcttattct caaggtatct ttgatatgag
    10861 aagtgagtta aatccttatc atttataaac aatgtaattt taggaggtct aatgtcagtt
    10921 tgagtcccat agtaaatttt taatcttcta cctttgtcag atggtggttg atttaacatt
    10981 acagcttctc caattacttc attcagtgct gaagttgata ttctcttaga atgttcattt
    11041 gacacatatt caactgtatc tagtatcttg ttcattcttt gattagtttt tgcagaaaca
    11101 aatacgattg gagcatacat cataaatgga aatttttctt ttatatcttt tgtgtaattg
    11161 ctcatagtct tattatcttt ctctattaaa tcccatttat tgattacaaa tatgcatcct
    11221 tttccttcat catgtgctat acctgcaacc tttgtatctt gttctgttac accttctaag
    11281 gcatctatta ctatcaatac tacatctgct ctatctacag cactcatagc ccttattaca
    11341 ctgtattttt ctattgtctc atatatttta ctttttcttc taagccctgc tgtatctatt
    11401 agaagaaatt tctgtccatt tttttcaaaa taagtatcaa ttgcgtctct agtagttcct
    11461 gcaattggac ttacaattac tctttcttct ccaagtatct tattgagtat agaacttttt
    11521 cctgcatttg gtttacctgt tatagctact cttattatat cttcttcata ctctgtatct
    11581 aatcctgctg gaaaattttc aactatctca tctaataaat ctccaaatcc catactattg
    11641 gctcctgaaa ctgcaaaagg cgttccaaat cccaactcat aaaaatcgta tatattatca
    11701 aattgacttt gactatcaat cttattaacc actaagatta ctggtttttt tgtctttcta
    11761 agcaattgtg caatttcttt atcagcagct gttattccag ctttaccatc aactataaaa
    11821 agtattacat gtgacatgtc cattgcaagc atggcttgat ttctcatttg agataatatt
    11881 atatcttcgc tatcaggttc aattcctcct gtatccacta atgtaaaata tttatctaac
    11941 cattctactt cagcaaatat tctatctctt gtaactccag gtgtattttc aactattgat
    12001 atcctttttc ctgcaaattt attaaatatt gtagacttac caacgtttgg tctcccaact
    12061 acagctacaa ctggcctact tatactcatt ttatttctcc ttccatcttt tgttttctat
    12121 tttaaaattt tatccacaaa atcttttcct tcattcaaac aagggataat ttttattctc
    12181 ataagttctt ctaattgatt taattcaata ttatctaaga aaatttcttc atctgctttt
    12241 agcatacttc ttgttatata aagagcttct cctaattctt tatcttcaag ttgttctttt
    12301 aaatccttag ctgttaaaag acctgataca gttattgtct ctccaaaaaa cttgtttttg
    12361 atttcatata catttacttg aagattttta aacttgtcca tcatagcatc tgccatactc
    12421 tgtataaatt catatgcaga atgaccagta gctattgata ctttcttctc tctttttaga
    12481 atcttctcag gcaatatatt tagatactct tcaatctctg tttttaactt acgtatcata
    12541 cctacaccat cttcaaactg taaaaaacct tcatattctt catatccagg caattcacta
    12601 ttagatagta tataaaattc atctgataaa aatgcaaatc gagtacctaa tttttcaaga
    12661 tatttctgtt gtatttgatg tatttgctct atagttttac ttgcgctctt atcattaaat
    12721 atatttaatt ctactagatt ttctctatgc tttgtaatcc caactggaac tatcgcaaca
    12781 ctgtttacat acggataaag ttgagctagt tcttttattg ttctatccaa ttcctttcca
    12841 tcatttatac ctggacataa aacaatttga cagttcattt ctatatgagc atctgccaat
    12901 ctcttcatta taccatataa ttttcctgca aatttattgc ttatcatttt ttgtcttaac
    12961 tctggattag ttgtatgcac agatatattt ataggactta ttctatattt tataatatta
    13021 tttatatctt cttcactcat atttgtaagt gtgacaaaat ttccttgtaa aaaagataat
    13081 ctcgaatcat catctttaaa ataaagagtt tctctcatac cttctggcaa ttggtctata
    13141 aaacaaaaca tacacttatt tctacagctt ttagcttggt caattatcgg atttgtaaat
    13201 tcaacaccca aatcttcatc atagtctttt tctatctcgt atatgtagac ttcgccatct
    13261 tttttttgta tttctacatc taaatattca tcacttagta agaatctata ctctattata
    13321 tcatgtattg gctgttcatt cacagatata agtaaatctc ctacctctat acccatttct
    13381 tctgcaatac tatctttata aaccttactt ataatattat ttactttttt tacatttact
    13441 tccaatattt tcaccactct tttgtattca tcaatgctta ttataatgta ttttaatatg
    13501 caatttattt atttattata ttttatgata gcatttttaa gcatttcatg tcataataac
    13561 acattttaat tctaatagtc aatataagta aatagctata aaatagatta gaacaaataa
    13621 tattcaaatt taagtttctt aaaaatttaa atattatttg ttcttaaaaa aattttataa
    13681 atttaatgtt ttactatgat taacgtccca tttgtcatat catgaaccat tccacctaca
    13741 cactttgaca tcaacaatgc cttattttgt aagtctttct catcatttgc ataaaatatt
    13801 ggacaacctc caccattttt catattctta tcaagtgtaa ctatagctag ggtatattca
    13861 tttaaaccta tatccattcc catctcatgc acttcctttc tttcctattt tataattttt
    13921 tagtgataag ttttttcctt tagagcttga aagtattggg catgacttta cagcttccat
    13981 tactttttcc acattcttat ctactggtaa ataagcaatc attatacttt catcctcttt
    14041 atttcttcta ggtaatggta cgaatgaagg ttctccataa tctccatata aacctaacct
    14101 tgaatatata ttgtatacta ttgcttgtct ttgaccggag tcaaataata ttcctgcatt
    14161 agcataatcc ttatttttag gaattatttg tattcctaca cctctattaa tatatacttc
    14221 tctatcgctt tttagaccta tatttgttat accttttaaa tctcccacct ttagtataga
    14281 ttcgtccaca aaactaattt cagcaggcat tacatcagct atgtctccaa tactttttct
    14341 agtaagaagt ttttttaata taaaggctaa cactaatcca caaattgaac ttattaccaa
    14401 actcatccct tcacttattt tcgtttctgc aagtattaca taatacaatc ctattgttaa
    14461 aaaagatgta actatacaca tataatttct tacttcatag gttctagcta tctcttctat
    14521 gaatgcagct cctctcttta caagttgaac ttcctctaaa ttttgcaatg tatttcttct
    14581 atttgctctc acttgtctaa attgttctgc tgctagagat aaaaaagtta tagatgtata
    14641 agaacgattt ataagagctg gaaccaataa tgctcctaat gaagaagcga cgaatgctaa
    14701 tataagttga gatagtaaaa catttggttg cgttggatac tgtttttggt ctaaattcaa
    14761 cattataatt ctagatgtta taccaataat aacagcaaca aaaaatactc tatccattaa
    14821 atcactccta aaatatttaa tttgaaattt tacatgtaaa tctacaaagt ctttctagaa
    14881 aaatcactct gctttccttt tgatgtttct atgataggtg tacttttcac tacatctatc
    14941 atgacatcta tatctttgag tattggcata tatggtataa ccacagtact tttttctaaa
    15001 ttggtcttag atatagcaac aatatcaacc tcatctacat ctctatctat ccccatatga
    15061 ataaatagat tatgtattat agcttgtctt tgccctatat catttactat tccaaatgca
    15121 cctaaatctc ttggtataac ttctatggcc agacattcat ttctatactt ttctcttgta
    15181 ctttctagac ctatgttagt tattattaca ccatttacca ttaaaatagg tccttcaaaa
    15241 cttatttttg caggaactat atctgctata tctgctatac tgttccttct taaaaatctt
    15301 ctaaaaatca aaccaacaat agctcctgac acaatagcta ggattgtgca ataaaaaaag
    15361 ctaaggccat actttcttgc aaaaacgata taaactatcg aagataccag tgcagaaaaa
    15421 agacttatat aacttctaga ttcatacgta gatgctattt cttcaacgta agcgtctcct
    15481 tttggtacta attcttcatt atcgatattc tttagtgtta ttctttcttg ttctgcaaga
    15541 ccttgaaact gttgtattgc tactgcaaaa aatgtcaagg ctgcaaactc cttatctata
    15601 agtgcaggta atgctatagc acctaacgaa gctgaaagcc cagatataat tatctgttct
    15661 aaataatctt gtggtcttga tgggtattgt ttgtctgtaa ctcttaaaac taatcctcta
    15721 cataatattc ctacaactaa tgcaactata aaagagtgtc taaataaatt tgcattcaat
    15781 aaactttctt ccattttctc agctccttct cttatatagt ttgtgcaaaa aacaaaaaaa
    15841 attcccttct atttaaggaa atttttttgt aatattgtaa ctataaattc gctaccaatg
    15901 ccaagttcac tttttacttt tatacatcca tttagtgatt tgactatatg ctttgttata
    15961 gccaatccta aacccgttcc tcctacatcc ctacttcttg ctttatctac cctataaaat
    16021 cgttcaaata tgcgttctac atcttctttt ggtatcccta caccattgtc tataacttta
    16081 attacgattt tttcttcatc ttttaacact acaacttgta caatcccatt atcttgggta
    16141 tactttatag cattatcaac taggtttaag aacacttgct ttatatagtc tttattggat
    16201 agtatactta ttgatttatc atcacattta tataaaactt ctatattttt ttcactagct
    16261 gaatgttgag ttatttcata tacctcttta aatacatcat atactacaac attttccata
    16321 agaagagtat ctttattttc tacaaatgat aacagcaata tatcatcaat caaccttttt
    16381 aatctatctg attcgctttc tattatttct aagaatctat ttctagtatt cacatctata
    16441 ttttcatttg actttagtgt ttcaacaaac ccacttatag atgtaagtgg tgttttaagt
    16501 tcatgactta catttgcaac aaaatcactt ctcatatttt caagtttaac ttttttagta
    16561 atatcttcta tatttactat cgaacctatt attacgttgt tagtattctg aagataaact
    16621 gggtctactt ttatcttata tacgatatca tctttagtag taatattagc agtttcatta
    16681 tctttagaac caataaattg aagtatttgt tttaatattt cttcttcttt tattacaaca
    16741 ttaatattat gaccttcaac taattgattt ggttcactct ttatcatttc ttttgcttca
    16801 tcatttatca gaagtatatt tccatttaca tctatagcta aaattccatg agatatactc
    16861 tttaatatag accttaactg taaatgttta tactgtactt cttctaaggt tttatccata
    16921 ttctttatca tatgattaaa atttctagct aattcgccaa gttctccttt ggctgatatg
    16981 ttaagcctag catgatattc attattactt actttttttg agacgtatat aaactctttt
    17041 aaatattttc ttaatgttat tgtgtatctt acagctaata taacaatggc tatggacaac
    17101 ataacaataa aaaaatatat actatttaaa tcttccacaa gataacactc ctaaaatata
    17161 acctttttaa tctattttgt atcctacacc tcttatagtc tctatatatt tttccgattt
    17221 atcttcatct tctatttttt ttcttaaata tcttatatga acatctactg ttctagtttc
    17281 tccatagtat tcataccccc atattttatc caaaagataa tttcttgaaa gtacttttcc
    17341 tttattttga attaataatt ttaacaattc aaattcctta agagttaact ctatcttttc
    17401 agagcctttg gtaacttcat gttttgataa atctagtttt aaattacctg tagtaagtat
    17461 attgttttct tcacctaagc tagtcaaatt atatctcctt aaaacagaac taatcctagc
    17521 taacaactct tttatactaa atggcttagt tatatagtca tcagcaccta tttcaagccc
    17581 ttcaaccttg tcattttcca tatttttagc agtaagcatt ataacaggaa tattttttaa
    17641 gtccttatca cttcttattt ttctcaaaac ttctattcca cttatatttg gtaacatcca
    17701 atctaaaagt attaaatctg gtttaatttc cttagccttt ataaatccgt caaatccatc
    17761 atatgaataa ctaacttcgt aatttgacac ctccaaattg aattttaata gctcaactat
    17821 atgcatttca tcgtctataa caagcacttt agtattcatt aaaaagctcc tctctatttt
    17881 atctgtagta ccgttcctat tcgttctgat gccttattat gttttctata agagtggaat
    17941 ttatctgctc tacaactagt gcataaattt aaatttatta tattttcttt tttaactcca
    18001 ctacatctaa gcatatactc attaattttc cataaatcta aatagtaact tccctctttt
    18061 attatataga acttttcatc attatttgta agaattgtgt taaatttttc tactaaatct
    18121 tcagacactt cataacaaca tggtccaatt gatggtccaa ttatacatac taaatcttca
    18181 ggaactgttt tatagcattc agacattaat tttattgttt tatgacctat attactaaaa
    18241 gtccctctcc aacctgcatg agccagtcct atggctttat ttttagcatc tataattgat
    18301 ataggtacac agtctgctgt aaacagtaaa agtggtactt tttccaagtt tgttataagt
    18361 gcatctccat ctcttctttt ccctatagta tctttattga ctatagtaac tatatctgaa
    18421 tgtatttgag aattactagt tagattttca aatgtcaaat cacattcttt acatactttt
    18481 aacatatctt ctctattttt tgcatctata ttcttacatg ttataactag atttacagaa
    18541 tttaattttt catcaagttc ttcacaatta ccacttaaat taacatactc tttaatatct
    18601 tgtacatttt ttatatttat ataatctttc atcatttgtc tcctttttct atcagtatac
    18661 ttttaagttc atttacaaaa gtatttatat ctttaaattg tctatacaca gaagcaaatc
    18721 ttacataggc aacctcatct aactctttca atttatccat taccatctca ccgatttttt
    18781 tggtttcaat ttcttctata aaacatttat ttatttcatt ttcaatatgt acaacaatac
    18841 tttcaatctc gtcaatagaa acaggtcttt tttcacatgc ttttagcaat ccatatttta
    18901 tcttttctct atcaaaatat tctctactat tatccttttt aatgaccatt aaaggagttg
    18961 tttctatttt ctcatacgta gtaaacctct ttttacatga ttcacactca cgtcttcttc
    19021 tgatagattt taaatctgta tgtctagaat ctattacctt tgattcttta taattacaat
    19081 aaggacattg catctatact cctcctttgt ttaactatat ctcaaactca tctaagctta
    19141 attctgaacc tatatttact attattgtat cacaacctat tttaagtata tcattccaaa
    19201 atataacttc ttcatcccct cctcttgaaa aaaaacttct acttccatct ccaaaaatgg
    19261 taaatgagac taccttacct tcgtgaatat ccatgtctat gtctattata aaccccatcc
    19321 tttttccatt ttttacattt ataatttctt tttccattat atcagaaact ctaatcatat
    19381 tgtactcacc ctttctttaa aaataaatat gtatcgaagt aaaaaaaaat gacctatata
    19441 ggtcatttaa attaaaataa tgtttacagt ccatggatta cttatacata ttttctcata
    19501 ttttttaaag catttttttc aattcttgat acttgtgctt gagatatacc gatttcatca
    19561 gcaacttcta tctgagttct tcctttgtaa aaccttaaat ctaataccaa cttttctcta
    19621 ctatttaatt tcttaatagc ttctttaagt gatatttctt gcaaccaatt ttcatcagta
    19681 tcttttttat cttgaacctg atccataacg aatattgcat ctccattgtc ttgatatact
    19741 gggtcaaaca gagatattgg gtcttgtatg gcatcaagtg ccattacaac tgattctact
    19801 tctaattcta attcctttgc tatttctgat actgtaggtt ctttagaatt tgttctaatt
    19861 aatctttctc taacttgtag tgccttatat gctatatctt ttaatgacct acttactcta
    19921 attgggttat tgtctcttag ataccttcta atttctccta taatcatagg aacagcataa
    19981 gttgaaaacc ttacattttg gcttaaatca aagttatcta tagcttttat aagaccaata
    20041 caacctattt gaaataaatc gtctatattt tctcctctgt tgttaaactt ttttattaca
    20101 ctcaagacta atcttaaatt ccctcttaca aactgttgtc tggcttcttc atcaccattt
    20161 tttatttgta ataaaagttc cttcatttgc ttatttttaa gaactggaag ttctgatgta
    20221 ttaacaccac atatttcaac cttattaact tgcatatatt ttcagtcctc tctcaaaagt
    20281 attcatctat tgaaattatt tacatttcca atttttttat actttttaag aagaattaat
    20341 ttagcattat acaaattttt tcatttcttt ttgcaacctt gagattattt tcttttcaag
    20401 tctagatatg taggactgtg atattccaag tattccagca acttcttttt gtgttttttc
    20461 aataccttta tcaataagac caaatcttaa ttccataatt tgcttttctc tgtcacttaa
    20521 tctgtcaagt gccataacca acaaatctct atctatttct tcttcaatta ttttgtatat
    20581 ttcatcattt tctgtaccca atacatcaga taataaaagt tcgtttccat ctaaatctat
    20641 atttaaaggt tcatcaaatg atacttctgt tttcttttta ttattttttc ttaagtacat
    20701 taatatttca ttttctatac atctcgaagc ataagttgcc aattttatat ttttattcag
    20761 tttaaaagta ttaactgctt ttatcaaacc tatagttcct attgaaatca aatcttctac
    20821 atctatacct gtattttcaa attttctcga tatgtagact actaatctaa gatttctttc
    20881 tattaaaatt gactttacac tttcatctgt ttctagcttt tgtaaaagct ccatttcttc
    20941 ttctggtttc aatggaggag gaagtatatt tgcccctccc atatagtata ttccctttgg
    21001 ctttattatt tttaatttaa tacctaacat agtaataaag cttattattc tttctttcaa
    21061 tcgtaacatt ccttgtcccc cttaaatttt cacctaaaat ccaggcaata tatttggatt
    21121 cattattgct ccatattctc tatcattaaa atttgaaata ccaagtatta tatttcctat
    21181 cttttgctca tctacttcta tatagtcagc ttttaagcct attattatgc ttgtcttatt
    21241 acttccagca tgtttataag gtattattct aactctacct gaagttttat catctaaact
    21301 tcctataatt tcttgtgctt tcttcatatc tatatcttca taattaatat ttaatagttt
    21361 ttctggaata aatccttcta acacactaga cttaactatt attacatcac tttgacttat
    21421 tgggtctttt aacaaattac cactatctac taaagcctta cagcaaaaac ttttttctag
    21481 taagtttata tttatagtct ttgtaagctc cttaatgtac ttaagcattt tcaaatcttt
    21541 ataaatgtat tttaataatt cacaactcac ataagtacat gcaattaaga aagatatttt
    21601 taagtgactt attcctgtaa aataaattat aaaataagtg cttccagaaa taaaaatgtt
    21661 tactagataa aaaactaacg ctacatgaac ataatctttt ttgctcttac ttctaaatga
    21721 aattaaagtt attatactca tgattattat tttaaatggt acagtaaata gtatattcat
    21781 tgatggatac aaataagcaa cagaataggc acctcctaaa ctagccccca ataacttatt
    21841 ttttttagga ttatatcttt tagtaagaat agaagtacaa cttataataa tataatttat
    21901 tactaggttt tctataacat agtactcaat atacaccatg tatcccccct taaaaccttt
    21961 aaacatatta taagatagta tgtacaaaat tttatgtcac ttttgatggt cgaatccaaa
    22021 acaaattcta tttaaaaaga acaatgatat atgtcttata ctttatgtcg tcaaaagata
    22081 tttttttaat gccaaacaaa tagacttttt tgtagaatcc aatatatcta ggtagaagtt
    22141 attcgctcta cttttggtat atttacaaaa aaagactaca taatttaata atatatcaag
    22201 taaatctttt acttatataa aatcaaatta tatagtctgt aaattcaaat ataaattatt
    22261 gtgctagtaa tccatttgca tattttgcag attcatttag tgcttgttct ggagttatgt
    22321 ctccagctat catcatttga agttgtttcc ataaatattc atatatctct actccatgag
    22381 gtccaactgt caatggtcta tacatatgtt tatctcttgt caccatttct tcaaatcttg
    22441 ggtctccttg gtatttttca cctttagcaa ctggagctct aggtatttct ttgtggaaag
    22501 cttccattga ttctttgctt agcatatact caagaagttt aaatccaagt tctttatttt
    22561 tacatgctga cattaatgtt aaatcatcta ctgaagcaaa acttccaact gtcttatctt
    22621 ctaatgatgt tacatatccc cagtttaaat ccgggaatga tttatcaaaa gtacttgtag
    22681 cagcagagga tagcattata gtaaatgcag cttttcctgg tccaaataca ctttcaatca
    22741 tttcattact atcttttgat aaagcatctt ctggaatata ctttttcata tcatttataa
    22801 agtttgcagc tttcaagcct tctgcattat taaatttaac tgattttaaa tcatcattat
    22861 atatatctcc accagcttgc cataaatacg gataccagtt ccagtttaag cttccaaata
    22921 ctttagaacc ccaaccttgt gcaagacccc actggtcgat ttttccatct ccatcagtat
    22981 cttttgttgc tttttcacag attcttttaa aatcatccca tgtttttgga ggtttttctc
    23041 ctaatttttc tagtatatct ttattgtagt acaatacgcc tggattagca gcttctatag
    23101 gtaaaccata aataccaccc atcatttttg catcatctaa gtatagataa ttatctgaag
    23161 ttcctgattt ttctaaataa ggtgttaaat cttctaccgc acccatttct ataaattgag
    23221 gaaacatctc tgcatacatg tatcctatat ctggaccttc acctgcactt attgctgttg
    23281 catatttttc tgcgtagtta tcccatggta ctatctgaaa ttcaatttca cagttatttt
    23341 ctttttcaaa tttttcaaat atcggcttcc atgcatctgc atcatggtct gttaatggtg
    23401 cagaccatac aactaatttt tctttaccct ctttgccttt agaatcttct ttttttgaac
    23461 atcctgcaag aattgatact gatagaatcc ctaccataac taaagaaaga acctttttta
    23521 gtttaatcat gcttaatccc ctttcagact ttaatttgtc tttttcctca aatgtttaca
    23581 tttaattcag atttaatatt aacaaataag attactcttg tctaatcata aaaaactata
    23641 ctaactccta taactatatt ttttttctat acctattaga tttaattcat actaaaaact
    23701 tactttttaa attttatcaa tatttaaaaa tatttttaag tctagccaca aactaactat
    23761 ctaaattgaa caaaataaaa agaagtctat tgacttcttt ataagcttac atattatctt
    23821 cttcttctta ggaatgtagg tatctccatg ctctcatcat catcttcttc aattatactt
    23881 gcctttttag gaggctctat tttttcctca gcaattactt cttcttcaat ttcttttaca
    23941 gcttgtttta ctgttgtatt taatgaagaa cgtatgcttg atttaggttt agtatctaaa
    24001 tctaaggcac cattttgtaa tccttcaaat cctgtcgcga ttactgtaat cattatttca
    24061 tcacctaaat cttcttttat agaagctcca aatataacat ttgcttctgg gtcacaggat
    24121 tccataacta aagttgatgc ctcattaact tcaaataatc ctaagttagg accacctgta
    24181 acattaagaa gtactccttt agctccttgt attgatgttt ctagaagtgg agattgaata
    24241 gcttgtcttg cagcatcaat tgctctagtt tcaccactag cactacctat acccatatga
    24301 gcaagtccct tgtctttcat tatagtagta acatctgcaa agtccaagtt tattaaccct
    24361 tcaactgcta taaggtctga aattgattgt ataccttgtt ttaatacatc atctgcaact
    24421 gcaaaagcat ctaacattga tgtatttttt tgtactatct gtaaaagtct atcatttggt
    24481 atcgttataa gagtatctac ttttgattta agttctgcta ttccaccttc agcgttcttc
    24541 attcttatct taccttcaaa tgcaaaaggt ttggtaacta cacctactgt aagtatcccc
    24601 atttcttttg ccaagcctgc aaccactgga gcagctcctg taccagtacc accgcccatt
    24661 ccggctgtta caaagaccat atcagctcct tgaagtaact ttactatttc atctttactc
    24721 tcctcagcag ctcttttccc tacttctgga tttgctcctg ctccaagtcc tctagttaat
    24781 ttttctccta tttgaacttt atattcagct tttgatgtat ataaagcttg tttatctgta
    24841 tttactgata taaattcaac gccttttagt tgagcttcta ccattctatt gacagcattg
    24901 tttccaccgc cacctacacc tattacttta atttgtgcac attcttctaa ttctacgtca
    24961 aagtttagca tcataaaccc ccttctctca tgattcaaag ttatcgtatg tattaattat
    25021 atcattttct tcttttattt tgttaacctt taagtaacat attccacaaa aacgtaaatt
    25081 ttccttttta aatttcttac ttatattgtc aaatattact ctttaagtat aaaataattt
    25141 acgtatatat taaatgctct ttaattttta cgttttttgt tcataatatt actaataata
    25201 tatcgtctaa ttatagataa gttattaaac aatctcatac caaaaactaa tacagcaaca
    25261 tagtaaagag aaactcctaa cttttctcct atataagtca ataatatagc caatatagca
    25321 ttacctatga aaccagtaat aaaaattaca ttatcatagt tatcttcaaa attggatttt
    25381 atcgctccaa aaatagaatc cattattgca agaatagcta ctgacatata tatggaataa
    25441 tccatagaat atgtaaatgg aatatagtaa cctactacta caccaaatgc taatcctcct
    25501 aaaacccata acataaatct tcacctcttt attttacttt gaaacacaac tacattacaa
    25561 tcctttttat taattttttt tactttttct ttattttttt gtatttttcg ttttattttg
    25621 caaataaatt cactttattt ccattatttt cctgaacttt tatattaatt ccatatatat
    25681 ccttaagaga tttagcatat gattctggag agtttatagc tgcactcaat aaatctatat
    25741 ctcctatagc ttttattata aatggttgtc catatgtagt atcatttact gtaatagtag
    25801 ctcctgaaca ttttatctta cttgttgcta gtactctttc tccatttata gaaattgctc
    25861 ttgctccagc cttttttaaa tcatttaaaa ccctcaaaat atctatatca tgtataatca
    25921 aatcgtttgg attctgtccg tcttttaact ctctctcact atccctcata gtaatagtta
    25981 tgcctggccc tgtaacagtt gaataaccac ttaactcttt aacttcttca agctcttttt
    26041 gcataagtgt ttggatagat tcatttccat tcttttttgc ttctttatat tcattcaaag
    26101 tttttttgtt ctttttaaga gtttctttta aattttttat ttcttttttt gtattttcta
    26161 cctcactttc aatactttca gtttgaccta atgttatgta tactctattt gggtctagtg
    26221 attttatata agttgatatg aaaacgccta atatgaatgc tcctaatata actattttct
    26281 ttttcatact attatttccc ctctgctttg tttatatcac tatgaccatt tatttctata
    26341 ttgtcttctt tggtcacttt tactttggca ttataatatg tttctatttc ccagacaata
    26401 ccatacttta tattaagtgc cgaagccaat gtatcagaat caccaattgc ttttattata
    26461 attggttctt ttatgacagt gtcattcata taaagcttgt cttcttttaa atacatatat
    26521 gtattagaaa ctattctctg gtcgtttata gatatggcac ttgcttgtgc tgaatttaat
    26581 ttatttatca ttgacaataa taaatcataa ttatatagta tactatcatt tttatcagag
    26641 tttcctaagt cttttgtaga atttatctca atttttatgc ctgttccttc aacatctgta
    26701 tatccagcta atgtttcata tttttctatt tctgacttaa gtatgtcttg ttctccttca
    26761 ttgtttttgc ctctataagt ctctatatct ttcttcacac tattaacttc tgattgtaga
    26821 ttctcttttt ctttttttaa agatttaagt tcttctgtaa gttgctctcc tcttttaaaa
    26881 gttgtcatcc ctctattttc tatattaata attttaagtt gtaaactaac aagaacaccc
    26941 aatacaatac ttcctatgat tatactttta tttataaatc tttttttcaa tatatcactt
    27001 ccttacaatt gtctatcctt ctggactata cactgccaac tttccatagt taagatttat
    27061 agtccctcca ttagtatttt tattttgcag gtcaatcaga attttactta ccctagatat
    27121 attataatct aagttatcat cattagaaag taagattttt atattacttc ttgtaagcat
    27181 ttctatattg ctttcttttt ttaagtttac ataatttatt tttctataaa ttccttcttc
    27241 ttttaaataa tttaaagttt taaatacatt ctccttagtt ttataatttt taaattttat
    27301 agatttatta tcatcaatgc tataatctac atctactatc aagtcttttt tactttcatt
    27361 agaacctctt agttcttcca ataaatttcc ttttttatct atataacaat aattatcttc
    27421 atcttttaat actgcaaata tttctttttc ttttaaactt ataattatct tattgggaag
    27481 ttttcttttt atttccacat tttctatata tggatttttt ataagtttat ttttcatatc
    27541 tttaaaattg tatgcaaaaa tattttcatt tagatttaca tttagttctt tcattatatt
    27601 tgatttggtc accctcttat ttccaattac atctattttc tttacatcaa ataaatcact
    27661 ttttacaatt atacatatac aaaaagataa cataagtata aaaactaaaa ctatcatgac
    27721 attattcgta tttaactttc ttcttttttt caaatataat caaccccttt ggttaataaa
    27781 tacaccttta gagcttgttt ttcctacaaa aaaattataa tatttaaagt caaatttttg
    27841 cattttatta cataacatcc aaataaggta ttaaatttta taaataaatc aatatttcat
    27901 caaaataaac atagcatact acatactatt tatatattta aatctgtata catacaaata
    27961 aacccctaat ttataataat ttagaaaatc taatatatta taaattaggg gtaaatattt
    28021 acttatcttt tctttattcc tattacctta gcttgacctt ctatacttgg agtcgtttct
    28081 ttttttattt cttttacttc cttaataact ttttcttttt ttgttttttt agaagctgat
    28141 ttttgtgttg aattgtatac tttcattatc tcatcatata taaggtctat ggcttcaggc
    28201 ttacctatag ttttacttgc atttgccata tcaaccaaaa gttctctatc tcctaaaagt
    28261 ttaaatactg ctgtatttag gctctctgga gttagatttt tttctaaaat agcaattcct
    28321 gccccttgtt tttctatact cttggcatta tactcttgat gattttcagc agtataagct
    28381 ttaggtatta ttatagatgg ctttccaaga gccgttatct cagctaatga aattgctcct
    28441 gcgctaccta taaccaaatc acttgctgca agtgcatttg ccatatcttc taagtaaggc
    28501 acaacttttt ggtatggttt aagatttata tcgctaatac ttcccataaa ttcatcataa
    28561 tagcttttgc ctgtagcaaa tataaaagct atatcttcat ttaccatatt ctttattaca
    28621 agtctcattg catcatttat ttttcttgaa cctccactac caccatagca aagtaccatt
    28681 cttttttcgt cacttattga tagattcttt cttgcaatat tttttcttga taataaaatt
    28741 tcttttctaa ctggatttcc tgtaaaaact aatttatctt ctgctgcctc tggaaatctt
    28801 ttatgcgaat cttcaaaact tgtaagtacc tttgtaactg ttttagataa aatcttatta
    28861 gttacaccag gaaaagaatt ttgctcatgt attatggctg gtattttccc catagatgca
    28921 ttaaataaaa caggtccact aacatatcca ccagttccta taactatatc tggtttaaat
    28981 ttcttaacaa tctttcttga ttgctccaaa cctttaaaaa gcttaaaaac tctttttaca
    29041 ttatcgaaat ctatttttcg cttaaaacct tgaactgtta cagtctttaa ttcaaatcca
    29101 tacttaggaa ctatttctga ctctattccc ttttccgtcc caacaaaaat tatctcagcg
    29161 tctggatgct catctcttat tttgtttgca atagctatag ctggatacac gtgccctcca
    29221 gttccaccgc ctgataataa aactttcatc aaatcatcat ctcctgttaa ttaattttga
    29281 catgctttga gatgtttaac actattccta cagctcccat aaagatggtg agtgaagttc
    29341 ctccataact tataaatggt agtgctacac ctgtagctgg cattgatgat gtcgcaactg
    29401 ctatatttaa agctgcttgt attccaattt gtgcacctat acctataaca accatacaag
    29461 caaatacatt agaagtcttc aaagctattc ttacacatct gtagactaaa actacaaata
    29521 gcataataac tattatacaa ccaatcaatc ctaactcttc tcctattata gcaaatataa
    29581 agtcattttg tggctctggt atataaaaat acttttgttt actctttcct aagcctagac
    29641 caaacaatcc acctgaacct agtgcatata gaccttgtat tacctgatac cccttaccaa
    29701 gagggtcttg aaaagggtct aaaaatgatg taacacgact aagtctatag ggttcagcaa
    29761 ttactaatgc agcaaataaa gcagccccac tccctatcat agcaaataca attttcatat
    29821 ccattccagc aacaaatatc attacaaaag taactagaat tacagtacct gctgttgaca
    29881 aatttggctg aagtattatc aacgcaaaaa atatccctgg aactacgaga agtggtacaa
    29941 caccttttgt caaagatttt attttatcat aatttttttc aattaatttt gcagttaata
    30001 ttattgtagc aaactttgcg atttctgcag gttgaaatgt taaagctcct attcccaacc
    30061 atctttttgc tccgtttgct tctatcccta aaggggtcaa aactaacaat aataatacta
    30121 ctgctatagc tccaattgct gtagcatttt tcttccaaaa actataatct attcttgatg
    30181 taataatcat aactataaat ccaagtacag catatattac attctttttt agaaaatagt
    30241 acgcatcatt gtgtttaaat gaagattgta taaaacttgc actaaacacc ataactattc
    30301 ctacaaatac taaaagcata gtagtgtaaa acactactcc atcaaattca gtcttcatcc
    30361 ttatgtcaat ttgttttttc aaattttctt taggcatcca actaatctac ctccattctt
    30421 ccatttaagt aagtttagag gtaagagatt attttaaatt gtttacatta tctttgaagt
    30481 cttttcctct tacttcaaaa ctttcataca tatcccaact tgcacaagct ggtgaaagaa
    30541 gcactatatc tccacttttt gaaatttcat aagaagtctt aactgcttct tccatatctt
    30601 ttactatatg tatgtcatta aatcctttat ttttagcaca attttctata tttgatgcag
    30661 tttctcctaa taagaccaat gatttaacat atgactttgc agtttcaaga agttcatcaa
    30721 aattacttcc cttatccatc ccccctgcta taagtattat aggtctatca taagactgta
    30781 tagcttttat agtggaatct ggattagttc cctttgaatc atttacatat attacattgt
    30841 ctaaatttct tacaaactct tgtctgtgtt ccactccttt aaatgtcata agtacatcct
    30901 ttataacttc taaatcaatt ttgcagacat atgctattgc tatagctgcc atacaatttt
    30961 ctaagttatg acctccaggt aaacttacat catctttatt tagaaatttg attttatcat
    31021 ctatatctat tattatgtca ttattttcta aatatactcc tccatttact tttttagttc
    31081 ttgaaaagta aattactttg gcattgcatt tatcagctaa agattttact atctcatcat
    31141 catagtttaa tacacagaaa tcctcaacag tttggttcat aaatatattt gcctttgctt
    31201 ctatgtattt ttccatagta tggtgtctat ttaaatggtc ctctgtaata tttaatattg
    31261 cgcttacttt aggtctaaat tcatctatac tctcaagctg aaaactgctt agttcagtta
    31321 ctaacacaga ctcttcactt gaagtttcta tagtatctat tacaggattt cctatattac
    31381 caactacata tgtatctcgt tttgctcttg aaaaaatttc tcctaccaaa ctagttgtag
    31441 ttgtctttcc atttgtacct gtaatcccta taaaaattgg attattcgat agtttaaaag
    31501 ctaattctac ctcaccaatt atatacttgc ctgaattttt taatttcaat atgaatggta
    31561 ggtctagtgg tacacctgga gacactacaa ccatatctat atcatctaca tcttctgggt
    31621 gatgtcctaa tatgtatttt atgtcattta tagatttcaa ttcatcaagt atatttctca
    31681 atttattttc atcttttata tcatttacga ttatacttgc acccaattta tctaaatgtt
    31741 taattgtaga tataccagtt tttgcaagtc ctactaataa aacttttttt ccttttaagt
    31801 ccatttttca ttccccctag ccctaaaata ctgctattat acttatccaa gctaaaacaa
    31861 ctgttataat ccaaaaaata aatacaactc ttgtttctgg ccaaccacac tgttcaaagt
    31921 ggtggtgtat tggagccatc ttaaagaatc tctttcttgt tgccttaaaa tatccaactt
    31981 gaatcaaaac tgatagagcc tccgcaaaat aaattcctcc aattataggt attataagca
    32041 ctgagttagt tagaactgaa aatgctacaa ctgcacctcc taatgccatt gaacctgtgt
    32101 cgcccataaa cactctagcc ggatatgaat taaatcctaa gaaacctaaa catgctccaa
    32161 cagttgctgc tgctaaaact gcgacttctg tatttccagc aatagaactt gcaaatagca
    32221 taaagaatac agaaactatt aatgttactc ctgatgctaa tccatctaat ccatcagtca
    32281 agtttacagc atttactatt gctacgatta taaacatcat tattggtata tataatattc
    32341 caacatttat cacaaaatct gtaaatggta tcataagttg tgaagcactt gatgatgatg
    32401 tatactgata aaaagcaaca taaaaagata atgcaacttg aaggattatt ttttgatatg
    32461 cttttagtcc aagtgatctt tttagcttta tttttataaa atcatctaaa aagccaataa
    32521 aaccaaaacc tgcaatacat ataagaccta ctgccatatc atgactaact tttactcttg
    32581 taagtccagt tattagaatt gcaacaatca ttataattcc acccatagta ggtgttccgt
    32641 ttttagctag atgtgtttgg ggtccatcat ctctaactgt ctgaccaaat ttaaattttc
    32701 taagcattgg tataaatatt ggtcctatta taattactat taaaaacgca atcaatgcgg
    32761 tgtacgtaag ctctgttatt cctaacatca taaaactcct ctcccttgtc aattaactca
    32821 ttagtttaag cttatttatt tagatattcg actatttttt ctaatctcat gcctcttgag
    32881 ccttttacta aaatagtgtc tcctgttttt actaattcat ttaacttgtt aaacacatct
    32941 tctctattct caaagtgata tatattggct gaattgaatc ctaattgttt tgcttcttct
    33001 ccaataaaca ctgaattttc acctatagtt attataatat cagtattatt catagatgat
    33061 tttccaacta atctatgacc atactctgaa atttcaccca tttctagtat atctccaagt
    33121 atcgctaccc ttctaccttt atatcttcca agtatcttta aagcagcatc catagaatct
    33181 ggactagcat tatatgaatc attaattatt gttaattttt cattttttat tatgtctagt
    33241 ctcatttttg tccctttaaa attttttaaa ccttttttta tataatctaa agaaatattt
    33301 agacacaaac caactaatat agcagacatt gcattatata tattatgttc tcctattgtt
    33361 ggtataaata tttcctcttt tttcccattt attacacata taaatgttaa actatcctct
    33421 tccatagtat aactttcaca ataaacatca ttgtttttat taaagccaaa tgtttttaac
    33481 ttatatacat gttctttttc ttttaatgta gataaaaact tatcatctcc atttacaatt
    33541 aaagtatttg tttcatcaaa gtttgaagta atctccatct ttgctttcaa aataccctct
    33601 tgtgaaccta gtttttctac atgtgataat cctatattcg atatgactgc aattttagga
    33661 tttactatat ccactaaata ttttatttca ttgaatccag acatacccat ctctattaca
    33721 gcacactcat gttctttatt tagattaaat aaagtcaatg gaactccaaa atgattattt
    33781 aagttttttt cattttttag tatatttaac tttgcagata tggcagagta aatcatatct
    33841 ctagtagtag tttttcccac actacctgta acacctataa atggaatatc aaatttttct
    33901 ttatagtatt ttgaaatatc tcctagagcc aaagatgtat cttttacctc tattaaattt
    33961 atatccgaac tttctaattt tattccatta ctttcatttt ttataaaagt tttacatcca
    34021 ctatcatatg cagacttcat aaatgtatgc ccatctaaat tttctccaac tatggctaca
    34081 aatgcatttt gggcatttgc ctccctgcta tctataacta tatcacttac acagtcatta
    34141 taatctccat atattaactt cccattagtt gcaagtacta actcttttat tgttaagcac
    34201 tccattatta aactcctcct ttaaaacctt agctatattc tcttagcaac aaaaggcaat
    34261 gtataccgtt atatatacat tgcctacgat aactcttaac tttataatta tatactatat
    34321 ttctgttttt ttgaagatgt ttatgggtat atgttaatta tctgttactt tttagttttc
    34381 aaaatatagg gttatacttg agtcttcatt aacttttact ccaggttttg ggaatatatc
    34441 ctttaccttt gtatcttctg gaagttctat atctgcatct aagtctggtt ttaacttcgc
    34501 atcctccaat gcctttacag catctcctat ttttagattt cttacatctg gcactttaac
    34561 ttgcttcttt tcatactcag ctttttcttc ttctttatat actggtttaa ctcccaaata
    34621 ttttaaagag tcattcatta tttctttcac tattggtcct gctgtagtac taccaaatgc
    34681 acttactcct gttggttcgt caacaatagc aagaactact atttgcgggt catcacaagg
    34741 tgctattcca acaaatgaac atatatattt tcctggagca tacttaccat ctataacttt
    34801 ttgagctgta cctgttttac caccaagtct ataacctggt atatatgcta tctttcctcc
    34861 accttcagtt acaactgatt ctgcaatttc taacattttt ttagatgttt ctttagatat
    34921 aacacttctt actttttttg gttttactgt ttcagttata tttcctttat tgtcagtata
    34981 agattttacc actcttggtt gcattaaatc tccaccatta gctattgatg atatagctgt
    35041 tataagttgt attggagtta ctgatataga ttgaccaaat gatattgtag ccaattcaac
    35101 tggtcctaca tttttttcgt tatacagtat tcccttagct tctcctggta aatctatacc
    35161 tgtcttatcc ataagaccaa atgattctat ataatcatac atttttccaa cacctaatct
    35221 gcttcctaac tcaacaaata ctgggttgca agagttttgt actgcttgtt taaattcttg
    35281 tgttccatga ggtctgtaat gtctccaaca tttaatcttt cttcctccaa cagttacact
    35341 acctgtacat gtgaattttt ctccatcttt aattactcct tcttcaagag cactggaaga
    35401 tgtaataagc ttaaatgtag aacctggttc atatgtatca cttactgctg gatttctcca
    35461 catttgataa tagcctttta ttttatcttt atcattatat ttttcaagtt cttcttgata
    35521 atatggatat attggcgttc ttgagtcatt agggtcataa tctggttttg atgctaaagc
    35581 aagtatatca cctgttttag ggttcatagc tattgcagta accttttttg cattatttaa
    35641 ctcataagct ttctgtactg ctttttcagt atagtgttga attacttcat ctatagacaa
    35701 cacaagacca ttaccttgta caggctcata atatttttcc attccttgtg gtatttctct
    35761 tcctgaagca tcagtactta ctataagttt tccaggcttt ccttttaact ttttatcata
    35821 ttgcatttct acaccagata tacctgttgc atctgaagaa gtatgtccta acacatatgg
    35881 tgcaaaattc ccatatgggt aatatctttg attatcttct gccacccata ttccacttaa
    35941 tttagcatct cttatttgac ttgccttatc atcatctatc catcttttta cttttacaag
    36001 agccatattt tttttgctta ttaaagcgta aatatcttta taatcttcat ccaaaatctc
    36061 agctaccttt tcggctgctt cttttttatc ttctacttcc acaggtttac accaaacagt
    36121 atacttagtt acacttactg ctaactcttt catatttcta tcatatatag ttcctctttt
    36181 gggttctatt ggtatatctc ttgtttgttg ttctagtgct tttgtactca accaatttcc
    36241 cttcataagt tgtagatacc cagtcctaat aacaaggcaa aaaaacaatg cacatgctag
    36301 aataagaacg agtaccagcc ttttcttact tatcctcttt acttttctca aatctattcc
    36361 ccctagttat ccacatctat atactttatt tgtccatctt ttggatagtc catattgagc
    36421 aattccttag cctttagctc aatttctttt attgatgttt tttcagtttc ttttgccttt
    36481 agttcctcta atactatctc tttttttctt aaatcttttt gtaaataata gatatcgtac
    36541 ttcatttccg agatttttga ataaccacat agattcaata ttattactga aaaagttgca
    36601 atcagtaaaa tgcatttagc tcctattttt ttcttatttc tctttttata attattcttt
    36661 tttttatttt tatattcatt tagattatgt attttataat tttttttcaa attctcaccc
    36721 cgatagtata tagtttaaat tttcctctat actatatttg ttattaatca tatttcttcc
    36781 tctaaaattt catcgctaaa ttaatacact attacacaat ctaattgtat ttttttctat
    36841 acacaacaaa aacctataaa ttcacttata cttttatatg aatctatagg ttagatatta
    36901 atttctattt atttttatca cttctagtat ttttagataa tttcttccat aaatataata
    36961 tgtaactagc tatctactct ctgattccta agttctccat tatattactt aataccatct
    37021 atatctatat ttttatatct aaattttcat tatatatctc aataacaaag aacatttctt
    37081 atagtgttaa ttgtttttta attgctttac cagtgcaaca aaatatataa tactttttaa
    37141 ttaattataa taatcttata tataagatta ttctttagcc ttataactac ttatattttt
    37201 tctgctactc ttagcttagc acttcttgaa cgtggattta cttctatttc ttcctcacta
    37261 ggtaatatag gttttctagt tattattttc acctcagatt ctttatcaca ttggcatata
    37321 ggtaaatgtt gtggacatat acaatctgat gctaaatgct taaatgcatt tttcactatt
    37381 ctatcttcta atgaatggaa tgttattata catattcttc caccttcatt cattatagaa
    37441 gaagcatcat ttatcatttt tgtaattact ccaagttcat tatttacttc tattcgtatt
    37501 gcctgaaaag ttcttttagc tgggtgaggt ccatctattc tagctttctt agggatagct
    37561 tttttaatta catctactaa ttctcctgta gtttctattg gtttgtttgc tctttcttca
    37621 actataaatt tagctatacg cttagcccag ttatcttctc cataatcttt tattatctta
    37681 gttaattcat cttctgtata agtatttaca acatcatatg cagaaaactc acacctaaca
    37741 tccattctca tatcaagtgg tgcatcttgc atataagaaa atcctctatc agcttcatca
    37801 agttgatgag atgaaactcc taaatcagct aatacaccat caattttgta aactcctatt
    37861 ttttctaatt cctcttttat attttcaaaa ttgctgtgaa caaacttcac tctactttca
    37921 tattcactca atctctcttt tgctgtgctt atagcatttt tatcttggtc aaaccctata
    37981 aataatccct tatctgacag tttttttact atttctttag aatgtcctgc tcctcccata
    38041 gtacagtcaa catacacgcc atctggcttt atatttaaat tctctataca ctcatttaaa
    38101 agaactgata catgatgaaa ttccatagtt acctccctta aattcacttt ttaaactatt
    38161 cttcactaat attattttta tttttctttg ataaataaac atgtgcaatt atgccaccaa
    38221 taactccaat tagacttata acttgtgcca ttctaagtgg tcctaacatt aaactatctg
    38281 ttcttaatcc ctctataaaa aatcttccta ttgaatataa agttatataa gtaactataa
    38341 cttgaccttc atatttttta ttttttctaa atagtaataa aactataaat attccaaaat
    38401 cccatataga ctcatataaa aaagttggat gtacctttac tccatcaacc attattcccc
    38461 aaggtaaatt ggtagcacct ccatgtgctt ctccattaat aaaatttccc catcttccaa
    38521 tagcttgtgc taaaggcatt ccaagtataa ctgtatcagc catttttaag aagttaatat
    38581 ttttaatctt agtgtatata taaccagcta atattccacc aattaaccct ccatgtatag
    38641 caagtccacc acctctaaaa ttaaaaattt gagacatatt ttgagcatag taactccaat
    38701 taaatacaac ataatagatt cttgcacaga ttagtccaac tggaattgct attatagcta
    38761 tatttaatac atcatcttct ttaattccca ctctttttgc ttcttttatt gctattaaag
    38821 ttcctaaaat cattccacat gccataagta ttccatacca catgatgtct atgccaaaca
    38881 gtgtaaatgc tactctatcc ataacgtcac ctctttgtat taattgaaaa tatttccaaa
    38941 gcaatatgct ataattacaa ttaattgtaa ttatactaaa ttatgataac acattaatgt
    39001 taattctaca aaaaatatta aaatttattc tacaactccc tacactatat tatatctaat
    39061 tactataaaa ttttttaaac tgaatctctc atgactaaag ttacaagtgt acatagatat
    39121 tttttaatca aaaagattga tgcatatata catcaacctc ttctattcct tatctatagc
    39181 tcttaaattt ttacctcaat ttatataaat atattttata aatttgtttt accaaaataa
    39241 acatttaaaa acataaacta atacttaatt agttattctt attatgatta agtttctatt
    39301 taggctctac aatagaaata acacaatact cttctttaaa atgctctttt aatctttctt
    39361 caacttcctc aaaagtaata tctttaataa catctaaata atccaataga tttatatcct
    39421 taaaaacata agatataaaa ctattaccta taaagtttat agaatcaaag cacttaataa
    39481 atgaccctat ttttttcttt ttagttctct caaactcttc ttttgataat ccttcttttt
    39541 ttgatttttc tatataatca agaattattt cttttacttt tttaggctct ttagaatctc
    39601 cagctattat gctaaaagca taatccactt gagacgaaaa tccagctcca aaattttcat
    39661 ttattaaacc ttgcatatac aaatcttcat aaagcttact tcctttttta aataacatcc
    39721 ctacaagtat atcagttaca atctctttac gtaaaagttc tttccctttt aaaccaacat
    39781 tgctatcttt aaaacctatg ttgaacatag gcatagatat agggaatttt tctataacct
    39841 ctttttcttt tacactttct ggttcttctg gataaaatct ttctatactc ttagagagtc
    39901 tgtctacttt gtaattgttt gactttttag ttacatctat aactttttct acatctaagt
    39961 caccaacaac aaataaagcc atatttcctg gattatagaa agtattataa catttatata
    40021 gctcttcctt agttatctta tatatactat caacagtacc tgctatatca attctagcag
    40081 gataatttac atacattgcc ttcaagcaat taaagtatac attccaatca gggtcatcat
    40141 tgtacatttt tatctcttgt gctattatac ctttttcctt ttcaacattt tcatctgtaa
    40201 aataaggtgt ttgaacatag tcaattagat gttctaaact ctcataaaaa ttttcagtag
    40261 cagaaaataa gtaggctgtc attgtaaaat tagtaaatgc atttgcattt actcctaatt
    40321 ttgaaaattt atcaaatgca tctcctccat caggttgctc aaacatctta tgctctagaa
    40381 aatgtgcaat accttcattc actctaattt tcttatcttc tccaattggt acaaattcta
    40441 agtcatttga accataatta gtagccaaaa tagcatactt tttcataaaa ccccttttag
    40501 gcataaaata tacatctaat ccattttgca atttctcata ataaacttct tctttcaata
    40561 tatcattaac tattttttcc atagacatct cctccattaa tttctcaaga agtatacagt
    40621 atcaagctct atatttttta tagcttcaac tatatctttt tttgtaacct tttctatact
    40681 agatattatg tcttgtactt cagaatttgt ctttgccata gactgagaga aaacaaaatc
    40741 agacatacca cctatattat cagttataga tttcatagaa ttaactaaag caagtttact
    40801 gttttctaat tcttcatcag atatatcacc tgcttttaca ctttctactt gtttttttat
    40861 caattctaca gctttatcat aatctttagt ttctatacca gatgatataa acatgatact
    40921 tttatacttc tctattgaag agaatatata gtaacataaa ctttcttttt ctcttacatt
    40981 aacaaataat ttagagtgtg gaccaccacc taagacattg ctcccaacta ctaaagcata
    41041 atatttatct atgtctgcat aatccacatt tgctctataa cccataacta acttaccttg
    41101 agttatttcc atttgttcat ctataacttt tacctcatcc acatttttta taaaatctgc
    41161 tcttggtata tttataattt cttctctttc aaattttaga tttttactta ttatatctac
    41221 aactttatct tcatcaaaat taccttctac aactatatct ataggtgatg ttttaagtat
    41281 gtttttataa tgttcatata actctcttga agttatacta tctatttcat cttcataacc
    41341 aaattcactt acactatatc tctctccttt acacatagcc tcaatacatt tatcttgcgc
    41401 atattccttt ttatcattta ttattgattg tatcttttct cttaaattct ctttttcaat
    41461 atttaaatat tcttctttaa acccaccatc tacaacaagc gtattattta ttacttcatt
    41521 aaaaaattct actacttctt caaatatact ctcatctaaa tacttttcac ttatgttaat
    41581 tactttaaaa ctcaatactt gacgttctcc acgttttaca gcatcagctc ccatagatga
    41641 accatataaa tcatctaatt tattggatat tgctctagca ctaggatatt tagcgcttcc
    41701 acttgctatt attgatggta ttagagcatt ttttgtagtt tctttttcat ccaatagtct
    41761 ctgaacatat aaacttataa gattcgattt aaacttttct gtttttatca aagtaagatt
    41821 aatattatta cctaaattta ttattttttt agtattaacc atatgtacct cctattttta
    41881 tttaaacatc aattttaaaa ttgaaattta tttatttttt aattacatat actcacatat
    41941 aaaaaccttc tatttaatta tatccttttt attattttct aaaagcaata tttttattta
    42001 aattaaatac aaatattatt taaatcaata tgctttaaag tctagtttac aagcttgata
    42061 tatatgatgt ataatcaaca tgtatgtcta taattaaaac aattttgcaa tcctatagat
    42121 tgattgttta aagttatata aagaatataa aaaagaataa gagagaggac gattaatatg
    42181 aaattaggta tagttggttt accaaatgta ggtaaaagca cactatttaa cgcaataact
    42241 caagcaggtg cagaatctgc aaattaccct ttttgtacaa tagacccaaa tgtgggagtt
    42301 gtatctgttc cagatgaaag attaaacaaa ctacaagaat tatataattc tgaaaaaata
    42361 gttcctactg ctatagaatt ttgtgatata gcaggtttag ttagaggagc ttctaaagga
    42421 gaaggtttag gaaataaatt cttatcacat ataagagaag ttgatgcaat agttcatgtt
    42481 gttagatgtt ttgaggatga aaatgttgta catgtagatg gttctgtaga cccacttcgt
    42541 gatatagaaa ctataaactt agaattaatt ttctcagata tagagattct tgaaagaaga
    42601 attaataaaa ctcaaaaagc tgctaaggct gataaaactt taggttctga acttgattta
    42661 ttaaaatcaa taatgtctac tttagaagaa agtaagtgtg taagaactat ggaatttaca
    42721 gaagatgaac aaacattcgt aaattcattg gatttactta catctaagcc tgtaatatat
    42781 gcttcaaatg tatcagaaga tgatttagct gataatggag aaaataataa atatgttcaa
    42841 caagttaaag catttgcaga aacagaagat gccgaagttg ttgtagtatg tgcacaaata
    42901 gaagcagaaa tttctgaact tgattctgct gaagaaaaga aagagttttt agaaacatta
    42961 ggtcttgaac aatcagggct tgataagctt ataaaatctt cttatgcttt acttggttta
    43021 atttcattct taactgctgg tccaaaagaa gttagagcat ggactataaa agttggaagt
    43081 aaagctcctc aggcaggagg aaaaatacat tctgatatag aaagaggatt tatcagagca
    43141 gaaacaatag cctttaatga tttggttgag catggtacta tggctgctgc taaagaaaaa
    43201 gggttggtta aattagaagg taaagaatac atagttaaag atggagatgt aatattattt
    43261 agatttaatg tttaaaatga ttaatcgtat acactttgac tattatatat aataactaa
//
LOCUS       DAEQCW010000021        43156 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.021, whole genome shotgun sequence.
ACCESSION   DAEQCW010000021 DAEQCW010000000
VERSION     DAEQCW010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43156)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43156)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43156
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.021"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            6..82
                     /locus_tag="KRO40_001183"
     tRNA            6..82
                     /locus_tag="KRO40_001183"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:40..42,aa:His,seq:gtg)
     gene            91..166
                     /locus_tag="KRO40_001184"
     tRNA            91..166
                     /locus_tag="KRO40_001184"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:124..126,aa:Lys,seq:ttt)
     gene            174..247
                     /locus_tag="KRO40_001185"
     tRNA            174..247
                     /locus_tag="KRO40_001185"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:206..208,aa:Cys,seq:gca)
     gene            255..331
                     /locus_tag="KRO40_001186"
     tRNA            255..331
                     /locus_tag="KRO40_001186"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:289..291,aa:Arg,seq:acg)
     gene            344..419
                     /locus_tag="KRO40_001187"
     tRNA            344..419
                     /locus_tag="KRO40_001187"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:377..379,aa:Val,seq:tac)
     gene            495..908
                     /locus_tag="KRO40_001188"
     CDS             495..908
                     /locus_tag="KRO40_001188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092010.1"
                     /translation="MYIVIGNEIVDSEELKIIIDKNSEFKVEKDLSKSTKREDVIAYQ
                     LSIDLNYLDSLINEQCNLASLSDEEKFDEYMTLSDELALDLEELMPKYTIINARAYKL
                     DEVDGIVKIILAVAYADLGHLKLSDVVKRLSRQVD"
     gene            1216..4647
                     /locus_tag="KRO40_001189"
     CDS             1216..4647
                     /locus_tag="KRO40_001189"
                     /EC_number="6.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate carboxylase"
                     /protein_id="HBH2092011.1"
                     /translation="MLKKFNKILVANRGEIAIRIFRACSELGIKSVGIYSKEDKYGLF
                     RTKADESYLIGEGKGPIDAYLDMDGIIDLAKRKKVDAIHPGYGFLAENAEFARKCEEN
                     GITFIGPSSKVMNMMGDKINSKKIAKEVNVQTIPGVEKAIRSTEEAKEVANKIGYPVM
                     IKASNGGGGRGMRIVHREEDLELEYETACSESRKAFGEDIIFIEKYIADPKHIEVQIL
                     GDNYGNIVHLYERDCSVQRRHQKIIEYAPAFSLDDKVRKEICEDAVKLSKHVGYSNAG
                     TLEFLVDANGGHYFIEMNTRVQVEHTVTEMVTGIDIVQSQILIAQGYSLDSEEINIKS
                     QDDVEIRGYSIQCRITTEDPKNKFMPDTGKIQVYRTGSGFGIRLDGGNGFTGANISPH
                     YDSLLVKTISWDRTFQGAINKTIRSIKELRVRGVKTNVGFLVNVLNNPIFSNGKCSTK
                     FIDENPDLFEITESKDRGTKLLQFIGDVIVNDNACKEKPLFDALHDPRMDKDGSKSEG
                     SKILFDKLGKSAYIEKIKNDKKLLLTDTTMRDAHQSLLATRIRTYDLLKAAKPTEKYQ
                     KDLFSLEMWGGATYDVAYRFLKESPWRRLQKLREEIPSIMFQMLLRASNGVGYKNYPD
                     NVIEEFTKESARQGIDVFRIFDSLNWVENMKPSINTALETGKIVEATMCYTGDILDKT
                     KTKYNLEYYIKMAQELESLGADIIAIKDMSGLLKPYSAYTLVKELKKNVKAPIHLHTH
                     DTSGNGVATCLMASEAGVDIIDAALESMAGLTSQPSLNAIVEALKNTERDTGIDLFGY
                     DELGKYYKDLRKVYNKFESDLTNSCAEIYNFEIPGGQYTNLKPQADSLGLVNRFDEVK
                     EKYKEANEVVGDIIKVTPSSKVVGDLAIFMTKNKLDKDNIIEEGKNLSFPDSVVDYCK
                     GMIGQPEGGIPKDLQEVVLKGEEAITVRPGSLLPAEDFDEIAKYLNEKYDINANIRNV
                     ISYALYPKVYEDYIKHLQHYNDISKLESDVFFYGLNKNEECEVEIEEGKVLTIRLVEI
                     GEVKENGFRTIGFELNGMVREVEIKDKNFSGKINNVEKADMNDPLQIGASIPGKVIKI
                     MVKEEDEVKANQPLIVIEAMKMETIIVAKTDGVIKSIKVKEDDMVEDKQLLMIMK"
     gene            4889..6817
                     /locus_tag="KRO40_001190"
     CDS             4889..6817
                     /locus_tag="KRO40_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBH2092012.1"
                     /translation="MKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDK
                     VNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSGDVVSSLRASDAAIIVIDATAPIQVGT
                     EKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFVKLH
                     NVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGI
                     QRGDIIPVICGSTINNIGTKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMS
                     YIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEIEKAKAGDIVVITKVNSLK
                     TGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRN
                     TETKQALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQS
                     GGHGQYGDVKIRFERCESDFEFTEEIFGGSVPKQYIPAVEKGLKDSMQKGILAGYPVT
                     NIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLKITVPEEYMGD
                     VMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERY
                     GEVPSQFAEKIIGLATAK"
     gene            7270..7734
                     /locus_tag="KRO40_001191"
     CDS             7270..7734
                     /locus_tag="KRO40_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HBH2092013.1"
                     /translation="MATMTDIIEKFIKDLMEEDNSIQIQRNELANLFSCAPSQINYVL
                     TTRFTIDRGYYIESKKGGGGYVQIEKIRKSKDGHIRELLNEKIGSQISYKKAKELLEG
                     LKESDLINERELKLILYAIDDKSLCMPIYELKEKVRSNILKNIIIGLFSIEE"
     gene            7741..8235
                     /locus_tag="KRO40_001192"
     CDS             7741..8235
                     /locus_tag="KRO40_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrB/UvrC motif-containing protein"
                     /protein_id="HBH2092014.1"
                     /translation="MLCQKCNKNKASVYYNKIVNGEKTEMYLCSECAKENTEMNFNLD
                     MPFSMMDIFSNLGFQPKKELEEKLVCPKCNTTYSEFKNNGRFGCSECYNAFSSQVNPM
                     LQNIHGHIEHTGKAPKKSFYKISVENEIKELKEDLDRAIKNEEYELAAQFRDKIKYLK
                     GSID"
     gene            8251..9276
                     /locus_tag="KRO40_001193"
     CDS             8251..9276
                     /locus_tag="KRO40_001193"
                     /EC_number="2.7.14.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein arginine kinase"
                     /protein_id="HBH2092015.1"
                     /translation="MKENIVMKSRVRLARNLNNYPFPNKLDKECAMEIIEKVKNAFIN
                     SNLEQKEEFDFYKIEDLDQSKKMLMVEEHIISPDLAENDKSAVIVKKDKTISIMINEE
                     DHIRIQTICDDLNLEYAYSVANEIDDLLESSLEYAFNTKLGYLTSCPTNTGTGMRASV
                     MMHLPALSQLGYMDELYKISSQIGIAIRGIYGERTEALGNIYQISNQLTLGRTESNII
                     ENVSGLTKDAISKEIKAREILQKKLGIKLEDKIFRSIGTLENSRVMSSAEAMSHLSNI
                     KMGIEMNYIDKLDLRAIEQLMIGIQPAHQSIMYKSDDVENRDINRATYIRETLEKLRG
                     GMNCELQ"
     gene            9263..11710
                     /locus_tag="KRO40_001194"
     CDS             9263..11710
                     /locus_tag="KRO40_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HBH2092016.1"
                     /translation="MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEG
                     IAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVLSPRSKQILELSGMFANKLKTNY
                     IGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
                     NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVG
                     KTAIAEGLATNIALGNVPETLKNKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKN
                     GNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGATTIDEYRKHVEKDS
                     ALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRY
                     LPDKAIDLIDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRD
                     EQGLLKKQLEDVRERWNKSSKHSDLVDGEVIAEVVGLWTGIPVNKILEEEADRLLRLE
                     EILHNRVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELSKALAEV
                     QFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEI
                     EKAHPDVFNILLQILDDGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAK
                     GDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVFHSLNENHISKIVLLMAAKLQ
                     ERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKG
                     SNVVAKVKDEKIVFETK"
     gene            11890..13263
                     /gene="radA"
                     /locus_tag="KRO40_001195"
     CDS             11890..13263
                     /gene="radA"
                     /locus_tag="KRO40_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HBH2092017.1"
                     /translation="MAKIKTKYVCQSCGYETAKWLGKCPECTKWNTFVEEIDQKSTKK
                     EVFIIDKSSSKPVSINSIESKEEERFTTDINELDRVLGGGIVKGSLVLVGGDPGIGKS
                     TLLIQVSSNVANLGKTVLYITGEESESQIKMRAKRLGINSENLYIFAENNLSIIESYL
                     ESVNPELIILDSIQTVFSPEISSAPGTVSQIKEGTSKFMKISKKMGISTFIVGHVTKE
                     GSLAGPKLLEHMVDTVLYFEGERYNTYRLVRAVKNRFGSTNELGVFEMRDLGLVELDN
                     PSKILISEKPKDVAGSVIISTVEGTRPMLLELQALVSPTSFGIPKRTSTGVDYNRVGM
                     LLAVLEKRVGLQIQNQDVYINIVGGIKINEPSIDLGIAISVASSFRNIPIDEDIAVTG
                     EVGLTGEVRAVSFIEKRIAECKKLGFKKIVVPRSNYDVVKETKGIEIWPVDNLRQAIN
                     IVLGRNQ"
     gene            13266..14336
                     /gene="disA"
                     /locus_tag="KRO40_001196"
     CDS             13266..14336
                     /gene="disA"
                     /locus_tag="KRO40_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA integrity scanning protein DisA"
                     /protein_id="HBH2092018.1"
                     /translation="MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATN
                     EDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSE
                     TGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
                     KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLV
                     SMQLEELMGTTRIDQKLIFKDYNKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSG
                     FSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDASIEELDEVEGIGEI
                     RATYIKNGLIKMKQLVLLDRHI"
     gene            14425..15519
                     /locus_tag="KRO40_001197"
     CDS             14425..15519
                     /locus_tag="KRO40_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIN/TRAM domain-containing protein"
                     /protein_id="HBH2092019.1"
                     /translation="MIRKVTRILFILLGFTIGITTYLTLMKDFEILTFGKETYGYIAA
                     VVAGIIIAILGYLIEPWVVNKVKEIAKIVDKELSKYPQTDILLGSMGLIVGFVIAYLL
                     SGLVNRIPIVGGILSLLLYLFLGYLGMKVALKSKNDLFNIGKLGRLANPIKDKDKDKE
                     NKKEVKAIPPKVLDTSVIIDGRIADICKTGFIEGKLIIPAFVLEELRHIADSSDDLKR
                     VRGRRGLDILNIIQKELNIEVEISERDFDDIAEVDSKLLKLAQVLNGKVVTNDYNLNK
                     VAQFQGVEVLNINELANAIKPVAIPGEDMVVQVVKEGKEAQQGVAYLDDGTMIVVDGG
                     RKYMNETIKVLVTSVLQTPAGRMIFAKPKN"
     gene            15648..17825
                     /locus_tag="KRO40_001198"
     CDS             15648..17825
                     /locus_tag="KRO40_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092020.1"
                     /translation="MRKKIISFLATFIIILTSASQYSFADDISTRGKVIFIDMNRTSM
                     SNMLRIKSLREELDNRGYIGLMNIRGDKGSDDRRSYASMGAGGRANVANEEDINFESS
                     SKDRNIVFESATGKSAKGINNLTINKSINENLNFGEYGSVLGSLGQSLSDNGLKASVL
                     GNSDIIENGQLIKNRNLCLTAMDEYGRIPNGNVDTINKKDLSMPYGISTDYDKLIVET
                     KEAYKNNDVIFVELGDTYRLDLYKPNLNEKTYESMKDSIEKNIDIYLKNIFSMVEEND
                     TVYIASAFPSDLDYKNKRRLSPIIKLNGEGKGILSSSTTRREGIVTNLDVGVEILDNF
                     NIKNQNMVGRKYELINRDDNKEFLMDEYQKIVSISSIRSTILNGFVSIVFLSWIVAMI
                     AILFRKHISKNYKETTFFILKELLKIGIVMPLSFMITPIMNFKTPLAISLGIIIITLT
                     IYLISKVLIKNDLKNMLFFTGLTIVIMVIDAGFGSYLMKSNVMSYDCIIGARYYGVGN
                     EYQGVAIGSAIFTFAILLTYKNIPKWSIIVFSLVILITSASPIMGANVGSAISECVAF
                     LLFILLIYNVKIDFKKIVLLGIAVVFVLGVFVAIDMILGSNSHLGMFVKEIYFNGPGE
                     IIQTFSRKIEMNLKLAQTSAWVNILLTGIGVILVLMINQIRYFKQLMDEYPIVFKGFI
                     ASIAGCLVTLLVNDSGIVSSATAFIYVIVPMITLSINLTALKE"
     gene            complement(18011..18856)
                     /locus_tag="KRO40_001199"
     CDS             complement(18011..18856)
                     /locus_tag="KRO40_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2092021.1"
                     /translation="MNRNNFSHEIIEPIDNLDVNFKLFDDSGSYVANHWHNSLEIIYI
                     TSGDLQINMEGYTYNLKANECMFINSGIIHSTRCIYQNTSILLQVPLSFLNKYIPDFK
                     NCYFDFKVNANDNNYKKNSSKVKLILENMREIKLSSPPAANLLFTSLLFELLFELYTN
                     FKISVGNKNMKKTVLDLSKFEPVLEYTKINYKMPISINKIAKVAHLQPEYFCRKFKQY
                     MGQTYLEYLNDVRISHIYKDLINTNDTLCSILEAHGFTNTKLFYRIFKEKFKCTPKHI
                     RKKST"
     gene            19073..20239
                     /locus_tag="KRO40_001200"
     CDS             19073..20239
                     /locus_tag="KRO40_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="HBH2092022.1"
                     /translation="MYIKGVNLGGWLVLEKWMTSSLFEGTEAEDEYYLPRQLSREAYE
                     SRIKTHRSEYITERDFATIKSMGFNSVRIPVPYFIFGDCEPFIGCVKELDKAFAWADK
                     YGLSILIDLHTVPGSQNGFDNGGISGICSWSQNPEYVAFTLNVLERLAKRYGMRHELY
                     GIQILNEPITERMWNIMNVPNRFKAVDKEMARGSKPNSLEFLRDFYIKAYKVMRPYMR
                     EENVIVFHDAFELKAWKDFMREEEFKNVVLDTHQYLMLAEADGCEQSIDSYLKYIREN
                     YAKDILQMQKYFPVICGEWSLFNSYACGIDTNGGQSPLNGIESNIDKLSKDDKRELYR
                     KIAKAQLDAWRNGSGHYYWNYKLLLDTVNEEGWIGWDSWDLGKCVAQEWYPIEY"
     gene            20261..21907
                     /locus_tag="KRO40_001201"
     CDS             20261..21907
                     /locus_tag="KRO40_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 43 protein"
                     /protein_id="HBH2092023.1"
                     /translation="MIKNPILPGFNPDPCICRKGDDYYLVVSSFEWFPGIPVYHSKDL
                     KNWELYTHILTDETKIDLKKLPSSKGIWAPCLTYCEEEDLFYIVYGIMNSMNARYFDV
                     DNYLITSKDIKGEWSEPVYLHSSGFDASIFHDDDGKKWIASLDWETREGYEKPGVICL
                     VEYCTKKKEIVGYPKRIWSGGTDRGCIEAPHITKRGDYYYIMCAEGGTGYGHSVTMGR
                     AKNIWGPYEKDSMNPIVTSIPGDFYERHDPDHLKPKYYNPESKLQKSGHGSYIETTSG
                     EVYLVHLTSRPFVPELRCTLGRETAIQKMKWTKDNWLRMEDESNLAKEYVSESKLEEH
                     LVSSIPSFDDFDSNELGLQYYAPRISPLSFADVKSRPGYVRIRGQESRTSLNKVSILA
                     RKLTSVYARITTKMEFYPEVHQHSAGLIMYYDNMNYINLRKYYSETLGQSALSIIHLE
                     NGEKTEFLNTRIPIKDIPIYLRLYIQGRKSYFEWSYDEKNYQRIGKVFDTTKFSDEYC
                     KYGEFTGTFIGLTCADRVKHKHYADFDFFEYIVDESKDVD"
     gene            22004..23377
                     /locus_tag="KRO40_001202"
     CDS             22004..23377
                     /locus_tag="KRO40_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2092024.1"
                     /translation="MNTEVNVKATTIKYEKISFFERISYGCGDLGCNIIYSAMSAFLL
                     FYYTNYADVSAAAVGSIMLVSRILDGFSDLTMGIIVDRTKSKYGKARPWILRMAIPFA
                     IAAVLLFSVPSNLGITSKLIYIFITYNLVSTVIYTAINVPYATLNSLITQNQYERGVL
                     SIFRMILATCGTLLINGLTLPLVEYFGNNLSAWTKTFFVFGIASIMVFFITFTGTKER
                     VKAVKQDRNEVIPFKIGIKSLFRNKYWIQITLCLVCIFIVFAINGGSSVYYAKFILGD
                     EKLFGPINMVSNISQIIAMFMVAPFIKKFGKRNVLIVGSIILISSNVMFIIVGQNHIG
                     VIFASAIKGIGSAGIASTMFAIVSDTIEYGEWKTGYRTEGLINSASSFGFKVGNGLGS
                     AILGAVLSIGGYVGTSATQSDLAIVSIKVCFIYLPIFITILQIIIMSFYKLDKEYSTI
                     LNELNTK"
     gene            23822..24775
                     /locus_tag="KRO40_001203"
     CDS             23822..24775
                     /locus_tag="KRO40_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HBH2092025.1"
                     /translation="MKKIGDLRLMMKCCSLYYEDNLNQQEIANQLGISRPTISRILKE
                     AFEQGIVKIQIVDVLKNDYQKIERSLERKYKLKEVIVVDDKQDALTQKQELARAVSEY
                     LTRVVKENDIIGVSIGTTLKEIPRYVEKSNCKNVTFIPLLGGIGDNEIDIHANQIAVS
                     LARAFGGDFKLLHAPAVMSDLSTKEKLCKDEKIKEVLDLIDKTTIAIVGIGNPMSLNS
                     TIMASGYMNEADIEDLKKYNSIGAICLQAFDKEGKTSILEFNQRVLGVKLEDLKKIKR
                     TIGVASGDEKIEAIKASLKAKFINSLAINHSLALKLLEDCD"
     gene            24813..25775
                     /locus_tag="KRO40_001204"
     CDS             24813..25775
                     /locus_tag="KRO40_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HBH2092026.1"
                     /translation="MSISKETLLEMYKRMNQARKFEEKVSWFFARGMVHGTTHLSVGQ
                     EASSVAAVMALEKGDLVSLTHRGHSQFIGMGIDLNKMMAELMGKETGFCKGKGGSMHI
                     ADIESGNLGANGVVGGGLTIAPGAALTQQYKKTGKIVLCSFGDGASNEGTFHEGINLS
                     SIWKLPIIFYCENNLYGMSTSIKRHMNIESIATRAASYGIEGISIDGYNPIEVYETVQ
                     KAAEKCRRGEGPVLIESRTYRWLGHSKSDANVYRTKEEIESWKAKDPIEFLKNYLIEN
                     NLSNEDELDKIQEFAKQSIEDAVEFAQNSPNPKIESLLEDVYAD"
     gene            25800..26786
                     /locus_tag="KRO40_001205"
     CDS             25800..26786
                     /locus_tag="KRO40_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HBH2092027.1"
                     /translation="MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSV
                     GMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPIMEVMFMDFVTISMDAIVNQAAK
                     MRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLL
                     KAAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSV
                     EEAAETLSKENINVEIIDLRTLYPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISA
                     LITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEEAIKSLIVR"
     gene            26799..27845
                     /locus_tag="KRO40_001206"
     CDS             26799..27845
                     /locus_tag="KRO40_001206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxo acid dehydrogenase subunit E2"
                     /protein_id="HBH2092028.1"
                     /translation="MVANKIKATPAARSQARKDNIKLDRLIGSGENGRIHLVDVLNYL
                     KDNKANTTPLARRIAEDLNIDLETIVGTGYNGKIRKCDVEKLTAKETIVSTNTSKSSE
                     KKELKIENENSSMFNTVEGIFEKPNPMRATVAKRMSESYFSAPVFTFNIEVDATELKV
                     LRAKLIDTVKESTGVKLTMTDLIVMAVSKILPNHQALNSAWTDEGIFRYKDVNIAIAV
                     GLDEGLYVPVVKNANKKSLKEIAKESKELAEKVKTGKLMPADQEGNTFTISNVGMYGI
                     TTFTPIINMPSSAILGVGATQDKFVPVNGEAKIKPIMNLSLTSDHRVIDGTVAAKFLK
                     DLKELLENPLSMLV"
     gene            28012..29742
                     /gene="lpdA"
                     /locus_tag="KRO40_001207"
     CDS             28012..29742
                     /gene="lpdA"
                     /locus_tag="KRO40_001207"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBH2092029.1"
                     /translation="MSVEVIMPKAGVAMEEGTIVSWLKQEGEEVKIGEPILEITTDKV
                     NMEIESEGEGTLAVIIHKEEGEVLPVFTVIGVIAEKGENQEEVKAKYLSGNVSKEDTV
                     KENQNIEVKEEKINKKECNHDYDVVVIGGGPGGYLSALKAALLGGRVALVEENILGGT
                     CLNRGCIPTKTYIKTAEILEEIDQLSKRGVKVTVDKEQDIKKAIKYKNRVVKKLTAGV
                     GGLLKSRDVDVFNLKASVKEEHKVILSDGKVLDTENIIIATGSKVRILPIKGIESNLI
                     ITSTEALDLETVPEELVIIGGGVIGCEFAEIFNSRGSKVTIVEMEDRVIPRMDKELSE
                     SLKYSLSKKGINVLTKKKVSEFKEEGNNILVCIEGEEPIKADLCLYAIGREANLSGIE
                     DLDIKIDKGSIVVNSKMETSMPSIYAVGDVTGGVMLAHAAFKMGEVAASNALGVNKEV
                     DLGALPSCVYTIPEVAAVGITEEDARKKYNVKVGKFNFAGNGRALASGQEQGYVKVVA
                     DAKYGEILGIHMFGCGVAELINHAASFKALEIPTDEASELIFGHPCTSEALMEALADV
                     NGECLHLPKK"
     gene            30160..33108
                     /locus_tag="KRO40_001208"
     CDS             30160..33108
                     /locus_tag="KRO40_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092030.1"
                     /translation="MRQRIKNLIENEDKKNPLTDEVISSRLNIRREDVTFLRNELKIE
                     DSRQRRKVVLIKAIKDILKEEKTINKNDITRRLNSIGFTVSRFTVIQYLKEIQDSGDL
                     KLDKESDDKKEEIINNRENKDIAFDKLIGSSGSLSTIIKLAKAAILYPPHGLHTIIMG
                     PTGVGKSELAECMYKFAVESSRFPKNAPFIVFNAADYSENPQLLLSQLFGHVKGAFTG
                     ADENKEGLVSKADGGILFIDEIHRLPHEGQEILFQLIDKGMVRKLGETRLTHKIDVMI
                     ISATSEPIDSHLLNTFKRRIPVTIEIPELVARPLNERFDIINNFFLIEAQRMGANIHI
                     KSDVLKALMLYDCIGNVGQLRSDIQVACARGLLNQLTNKLKEVNISISDVPGYVKQGL
                     IKIRNCRGKIENYVDGDLIIDSNLQGEIEKKNEDIYTFPDEIYKLTERRHIDLLEQGL
                     DFDVINRIIGGELESCIQKYIKQVKKVSISNNLPDISPIVGKYIVELTYEVIKIASQY
                     LSSLEPNLHLCLAVHLKAAFERLKEGKVISNAHLKEIIGNYPVEYSVAEKVAQYLKER
                     YNINLPKEEIGIIAIYFKMSSRRDMSEQKKIGVLLMAHGRVASSVCEVTNKLLGINHA
                     RYLDMPFEKKPEEMIEEATTIIKDIDEGRGVIILVDMGSLSYFGDIISGKTGINIRTI
                     SRFDTLLSIEVIRRAVLPDLTIDEIVDEVKGIEPQVKEKVSKCNNTKVDFRKPIILTL
                     CITGLGGACKIKKILEENIKSITEKVDIEPIGMIEYPSLDLEIKQISNDKNVIAIVGT
                     IDPQIANIPFFSLVDINDKAKLNQINNLIDTNQIGETNKKYELSDLIHKEDIFVDLQV
                     KSKEEVLKYMSKKLREKGYVTKNFYKKVVERDNLFPTELSDEIAIPHTDGIDVIRPAI
                     SIAILKKPIVWSKSKVKIILLLAVDQKCFNPLSTLLSFIETDEFKKIKNIKDRDFIRE
                     MILDGVNENN"
     gene            33086..33550
                     /locus_tag="KRO40_001209"
     CDS             33086..33550
                     /locus_tag="KRO40_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092031.1"
                     /translation="MESMKIISSNLIFKNIEVSNNEDALKFLGQRLFDEQYVKESYIQ
                     AVVAREKKYATGLPTEIYGVAIPHTDIVHVNEPGIAIGILNKPVKFIMMGTDDTEIDV
                     KVVFMLAVKEPQEQLQLLEKLMTIFQDKNILNNIVDLSEESVSDLLNSKLKN"
     gene            33663..33965
                     /locus_tag="KRO40_001210"
     CDS             33663..33965
                     /locus_tag="KRO40_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092032.1"
                     /translation="MGVTNVAKKILVACGTGVCTSTIAINKLKKALQDIGKLDMVNIT
                     QCKVVEVASKAPDYDLIICTTQVSSSIKTPVINGLPFLTGVGMDKLINDVLEELEL"
     gene            34027..35391
                     /locus_tag="KRO40_001211"
     CDS             34027..35391
                     /locus_tag="KRO40_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425524.1"
                     /note="with GatAB forms a phosphoenolpyruvate-dependent
                     sugar phosphotransferase transporter for galactitol;
                     subunit IIC forms the translocation channel and contains
                     the substrate binding site; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH2092033.1"
                     /translation="MEGLYMEILNFIVGLGAQVMMPIIICIFGLILGTKLGKSLRAGL
                     TVGVGFIGLNTIIALLTDNLGPATQQMVKNLGLSLSIIDVGWPAASAIAFASTVGALI
                     IPIGLVVNIVMLITNTTQTVDVDIWDYWHFAFTGALVAGATQSVMWGVFAAVANMVIV
                     LVMADLTAPGIEEYLGMPGISLPHGFTQAFVPIAIVVNKLLDLIPGINKIEINADTLQ
                     KKFGLFGEPLIMGSVIGVIIGIAAKYDIKGILQLGVTMGAVLILIPKMAALLMEGLLP
                     VSEAAQEFIEKRFKNRGKIYIGLDSAVGIGHPVTLSVALVLVPLTILIAAILPGNKVL
                     PFADLAVIPFALVLIVPITKGNVFRTLIIGIIIITSGLLIATNLAPLFTQMALNASFK
                     MPEGATMISSICDGANPLSWVFVKVMNYKVIGGVVFGVIALGMAIYNRNRIINENKKL
                     SIEE"
     gene            35426..35899
                     /locus_tag="KRO40_001212"
     CDS             35426..35899
                     /locus_tag="KRO40_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092034.1"
                     /translation="MKKYKYDSKRYLLSVTIPGFFMILILIYALFNNYTNFNLNIYSL
                     LIIVCTYSIFNTFISSSNPKKIIIDSKCIHFTSFMTTHKYELKDIEKIRIREFYNKKI
                     YLKINDGNLFKGRYWIRTNMFNNSIALYSYFIELEECLYPDSLKFRNKKFENKNI"
     gene            36071..36721
                     /locus_tag="KRO40_001213"
     CDS             36071..36721
                     /locus_tag="KRO40_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBH2092035.1"
                     /translation="MLLEKLRKEVLQASLDLLNYNLVTLTGGNVSGRDEQTGYIAITP
                     SGMDYRNLTPSDIVIVDVDGNIIDGKWKASVDLSDHLYIYKHREDINSIIHTHSTYSS
                     CFAILNEPIECASTTLANEVGGSVPVAKFSPPTSKKMGKCVIEAIGDKRACLLANHGV
                     IAVGPSVGHALTAAVMLEDSAKVYYLAKSIGTPVLLPDEEIQRARDVFFNVYGQDK"
     gene            36895..37827
                     /locus_tag="KRO40_001214"
     CDS             36895..37827
                     /locus_tag="KRO40_001214"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBH2092036.1"
                     /translation="MYYLLNKSTNPYFNLALEEYLFLNDKYNDDIIIIWRNEESIFIG
                     KNQNPYQEVYHDVIEKGEIPILRRISGGGTVYHDLGNINMSFIQKDRQLHEIDFLEHT
                     KFMQKMLSTLGLDVSITERKDLFLNGKKISGSAQSIKRKNSLYHGTLLYDSDLNKLTK
                     YLNSNKATESNATKSVSSKVTNIKFLLEKDINYFLDYCVEYLKSNIKNIKELELDEED
                     IKSVYNIGEDKYKKIEWTYGKTPKFQVVLPFNNESKINIHVNRWKVSKFFISYDDNVI
                     NMDKLLDLNFFKEEIKESILENYPHYIDLINLIF"
     gene            38101..38814
                     /gene="ispD"
                     /locus_tag="KRO40_001215"
     CDS             38101..38814
                     /gene="ispD"
                     /locus_tag="KRO40_001215"
                     /EC_number="2.7.7.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HBH2092037.1"
                     /translation="MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENIN
                     IDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGKERQDSIYNGLKKLDKNCDIVLI
                     HDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQT
                     PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIA
                     EQILNMEKRDEVNSRRRII"
     gene            38811..39296
                     /locus_tag="KRO40_001216"
     CDS             38811..39296
                     /locus_tag="KRO40_001216"
                     /EC_number="4.6.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /protein_id="HBH2092038.1"
                     /translation="MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAI
                     MDSILGALALGDIGKHFPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQS
                     PKMAPYIESMRSNISKVLNTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQN
                     N"
     misc_binding    39391..39599
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            39663..41378
                     /locus_tag="KRO40_001217"
     CDS             39663..41378
                     /locus_tag="KRO40_001217"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH2092039.1"
                     /translation="MKMSKMFMPTLKEIPADAEITSHQLMVRSGMIKKMTSGVYNQLP
                     MGLRVFKKIEQIIREELNKKDCQEILCAALLPSELWKESGRWTAMGEEMFRLKDRTER
                     EYCLGPTHEEAFTDIIRQEITSYKQLPLNLYQIQVKYRDERRPRFGVMRTKTFTMKDA
                     YSFDVDDKGLDKSYQDMFDAYVSIFNRCGLENSPVQADSGAIGGSTSAEFMVKSEVGE
                     DEVVFCSGCDYAANVERAESCNLASQKEEMKELEEVHTPGAATIKELEEFLKTSPDKF
                     AKTLVYEADGKTVVVVVRGDREVNEIKVSNAIGSVIEFALATDDVVRKVTNAEVGFAG
                     PIGINADYVFIDKEIVEQRNIVVGANKTEYHIKNANYGRDFEGIVGDFRNVQEGDKCI
                     VCGKPLEIARGVEVGHIFKLGTKYSESMNANFIDKDGKSKPIVMGCYGIGVERTAAAI
                     IEQHNDEKGIIWPLSVAPYHVVIVPANMKNEEQISIAENIYNDLQAMGVEVLLDDRDE
                     RIGVKFNDSELIGIPMRITVGKNINEGKVEFKLRHKEDKEIIDIEEINEKVKAEFIRN
                     NVRLG"
     gene            41500..42945
                     /locus_tag="KRO40_001218"
     CDS             41500..42945
                     /locus_tag="KRO40_001218"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH2092040.1"
                     /translation="MAKNEKQFVEEITKMEDDFPQWYTDVITKTDLVDYAPVKGFMVV
                     KPYGYALWEKMQEFMDKKFKETGHKNCYFPLLIPESLLNKEAEHVEGFAPEVAWVTHG
                     GNKKLEERLCVRPTSETIICTMYAKWLKSYRELPYLYNQWCSVVRWEKSTRPFLRTSE
                     FLWQEGHTLHETAEEAQEETIQQLEVYKALCEELLAMPVVAGQKSESEKFAGGERTYT
                     IEAMMHDGKALQSGTSHFLGQHFTKAFDITFADREGNLANPYHTSWGASTRLIGGLIM
                     THSDNRGLVLPPRVAPIQVVIVPIAAKKGNVMETVDKIYADLKAKGVAVEVDDRDNYT
                     TGWKFNEWEMKGVPVRVEIGPKDIENNQAMVFRRDTLEKDSMPLEGLADAICDLFDVI
                     HNDMFEKARKHREDNTSIVENMDEFRKALEEKPGFIKTMWCGDAECEAKIKEETGATI
                     RCLPFEQENLGHKCVYCGKEADSMVVMAKAY"
BASE COUNT        17625 a         4558 c         8072 g        12901 t
ORIGIN      
        1 ttatggtggg tatagctcag ttggttagag cgccagattg tggctctgga ggtcgtgagt
       61 tcgactctca ttatccaccc caacttatat ggtctattag ctcagtcggt agagcacctg
      121 acttttaatc agggtgtccc gcgttcgagt cgcggataga tcaccaaaaa ggcggcgaca
      181 tagccaagtg gtaaggcagt ggactgcaac tccttgatcc ccagttcgaa tctgggtgtc
      241 gcctccaata aaatgcgctc atagctcaac tggatagagt gtctgactac gaatcagaag
      301 gttaggggtt cgagtccctt tgggcgcacc atatgaatag cgagggatta tagctcagct
      361 gggagagcac ctgccttaca agcagggggt cacaggttcg agccctgtta atcccaccag
      421 tgcaaacctc tagtaaaact actagaggtt ttatttttga ttgaaaaagt ttttatattt
      481 aggaggtaaa aaatttgtat atagtaatag gaaatgaaat agttgatagt gaagaactta
      541 aaataattat agataaaaat agtgaattta aagttgaaaa agatttaagt aaaagcacaa
      601 aaagagaaga tgtaatagca tatcagttaa gtatagattt aaattaccta gattctctta
      661 taaatgagca atgtaattta gccagtctat ctgatgaaga gaaatttgat gaatatatga
      721 ctttgtctga tgaacttgca ctggatttag aagagttaat gccaaaatat acaataataa
      781 atgctagagc atataaatta gacgaggtag atggaattgt aaaaataata ctagctgtag
      841 cgtatgcaga tttagggcac ttaaaacttt ctgatgtagt aaagaggcta tctagacaag
      901 tagattagga tatgaatatg aactatatta aaaaaatgta taaaatctta cgtaaagatg
      961 aaaataatta tgtaaacata gaaaaaacag tataaaatca agtcaattgt agaaattttc
     1021 acataaattc atctgaaatt ctataaaaaa tgccttaatt ttaatgaggt aaatcgagtt
     1081 tacacagtct aaaaattact tatatttata aatttatctt attaattaag gaactttctt
     1141 aaacatcttc aaaaataaag tattttagtc tataatcttt aatattacac aaacaataaa
     1201 ggagaagaat agagtatgct taaaaagttt aataaaatac tagtggctaa tagaggcgaa
     1261 atagctataa gaatatttag agcctgttca gaattgggga taaaaagtgt tggtatatac
     1321 agtaaggaag ataagtatgg attgtttaga acaaaagcgg atgaatcata tttgatagga
     1381 gaaggtaaag ggccaataga tgcatattta gatatggatg gaataataga cctagcaaag
     1441 agaaaaaaag ttgatgctat acatccagga tatggttttc tagcggagaa tgcagaattt
     1501 gctcgtaaat gtgaagagaa tggaattact tttataggac catcatctaa ggtaatgaat
     1561 atgatggggg ataagattaa ctctaaaaaa atcgcaaaag aagttaatgt tcaaactata
     1621 ccaggagtag aaaaagcaat aagaagtact gaagaagcaa aggaagttgc aaacaaaata
     1681 ggatatcctg ttatgataaa agcatctaat ggcggtggcg gtagaggtat gagaattgta
     1741 catcgcgaag aagacttaga gcttgaatat gaaactgctt gtagtgaatc aagaaaagct
     1801 tttggagaag atattatatt tatagaaaaa tatatagctg atccaaaaca tatagaagtt
     1861 caaatattag gtgataatta tggaaatata gttcacttat atgaaagaga ttgttcagtt
     1921 caaagaagac atcaaaaaat aatagaatat gcaccagctt tttcgttaga tgataaagta
     1981 agaaaagaga tatgtgaaga tgcagttaag ttatcaaaac atgtgggtta ttctaatgcg
     2041 ggaacattag aatttttagt agatgcaaat ggtgggcatt attttataga gatgaacaca
     2101 agagtacagg ttgaacatac tgtaacagag atggttacag gaatagatat agttcaaagt
     2161 caaatactaa tagcccaagg ttacagctta gatagtgaag aaattaatat aaaatcacaa
     2221 gatgatgtgg aaataagagg ttactctatc caatgtagaa taactacaga agaccctaag
     2281 aataaattca tgcctgatac aggtaaaatt caagtttata gaactggttc aggatttggt
     2341 ataagactag atggaggaaa tggatttaca ggggcaaaca taagtcctca ttatgatagt
     2401 ttattggtta agacaatatc ttgggataga acattccaag gagcaataaa taaaactata
     2461 agatctataa aagaacttag agttagaggt gttaaaacta atgtaggatt cctagttaat
     2521 gttttaaata atcctatatt ctcaaatggt aaatgtagta ctaagtttat agatgaaaat
     2581 ccagatttat ttgaaataac agaaagtaaa gacagaggaa caaaattact tcaatttata
     2641 ggagatgtaa ttgtaaatga taatgcttgt aaagaaaaac cattatttga tgcattacat
     2701 gacccaagaa tggataagga tggttcaaaa tcagaaggaa gtaaaatact tttcgataag
     2761 ttaggtaaat ctgcatatat agaaaagata aaaaatgata agaaattact attaacagat
     2821 acaacaatga gagatgcaca tcaatcatta ttagcaacaa gaataagaac atatgactta
     2881 ttaaaagctg ctaagccaac agaaaaatat caaaaggatt tattctcact tgaaatgtgg
     2941 ggaggagcta cttatgatgt tgcatataga tttttaaaag aatctccttg gcgtagatta
     3001 caaaagctaa gagaagaaat accaagcata atgttccaaa tgttgcttag agcatcaaat
     3061 ggagttggat ataaaaacta tccagataat gtaatagaag aatttacaaa agaatctgct
     3121 agacaaggta tagatgtatt tagaatattt gattcattaa actgggttga aaatatgaaa
     3181 ccatctatta atacagcttt agaaactgga aaaattgttg aagcaactat gtgttataca
     3241 ggtgatatac tagataagac taaaactaaa tacaatctag aatattatat aaaaatggca
     3301 caagaattag aaagcttggg agcagacata atagcaataa aagatatgtc aggtcttctt
     3361 aaaccatatt cagcttacac attagttaaa gagttaaaga aaaatgtaaa agcaccaata
     3421 catttacaca ctcatgatac aagtggaaat ggtgtagcaa cttgtttaat ggcgtcagaa
     3481 gctggagtag acataattga tgctgcatta gaatctatgg caggacttac aagtcagcca
     3541 tcacttaatg ctatagtaga ggcacttaag aatacagaga gagatacagg aatagattta
     3601 tttggatatg atgagttagg aaaatattat aaggatttaa gaaaagttta taataaattt
     3661 gaaagtgatt taactaattc ttgtgcagaa atatataatt ttgaaatacc aggaggccaa
     3721 tatacaaact taaaacctca agctgatagt ttaggattag ttaatagatt tgatgaagtt
     3781 aaagaaaaat ataaagaagc taatgaagtt gtaggagata taataaaagt aactccatct
     3841 tcaaaagttg taggagactt agctatcttt atgactaaaa ataaattaga taaagacaat
     3901 ataatagaag aaggtaaaaa tttatcattc ccggattctg ttgtggatta ctgtaaaggt
     3961 atgattggtc aaccagaagg tggaatacca aaagatttac aagaggtagt tctaaaaggt
     4021 gaagaagcta taacagtaag accaggttca ttattaccag cagaagattt tgatgaaata
     4081 gctaaatatc taaatgaaaa gtatgatata aatgctaata taagaaatgt tataagttat
     4141 gctttatatc caaaagtata tgaagattat atcaaacatc tacaacatta taatgatata
     4201 tctaaacttg aaagtgatgt attcttctat ggattaaata aaaatgaaga atgtgaagta
     4261 gaaatagaag aaggtaaggt attaacaata agattagttg aaattggtga agttaaggaa
     4321 aatggattta gaactatagg atttgagtta aatggaatgg ttagagaagt agaaataaaa
     4381 gataagaatt tctctggaaa aattaataat gttgaaaaag ctgatatgaa tgaccctctt
     4441 caaattggag caagcatacc aggaaaagtt ataaaaataa tggttaaaga agaagatgaa
     4501 gtaaaagcaa atcaaccatt aatcgttata gaggctatga agatggaaac tataatagtt
     4561 gctaagactg atggagtaat taagtcaatc aaagtaaaag aagatgatat ggttgaagat
     4621 aaacaattat taatgataat gaagtaattt aattaaaata aattaaaaag cactctgaaa
     4681 tgtttaataa aaaatgtttt agagtgtttt tatttatttt aattaaatat ttgttaaaaa
     4741 aaagaggaca attacctcca gatgtagaaa taaagctagt aaggaaaatg ttatctaaaa
     4801 attctaaata tagtaaatat tttccataat atttcttagg aaataacagc aaagataaaa
     4861 tacataaatt taaaaggtgg gtgcttatat gaaggtttat gatagtaaaa tgttgagaaa
     4921 tgtagcggta ttaggacata gcggatgtgg aaaaacaaat ctaatcgaaa ctatagctta
     4981 cacagcaaac actaataaga tacctaaatt aacagacaag gtaaatatga cttatagcat
     5041 gggattaata cctatagagt ataatgatta taagtttaac ttattggata ccccaggata
     5101 ttttgacttt agcggagacg ttgtgtcatc tcttagagca agtgatgcag caataatagt
     5161 aatagatgca acagcgccta ttcaagttgg tacagagaaa tcattagaac taactgagag
     5221 tattcctaag ataatgttta taaataaaat agataatgaa aaggcaagat acaaagatgc
     5281 aatagcaatg ttaagagaaa aatacaataa taagatagtt cctatgataa gtcctatata
     5341 caaagataaa aactttgtaa agttacataa tgtttttgaa aacatagatg atttagaagg
     5401 tgaatttaag gaacaagcta tgagtgttaa agaagcatta atggaactta tagcagaaac
     5461 tgatgaccaa atattagata aatattttaa tggagaagaa ctaactacag aagagataca
     5521 aaaaggtatt attataggta tacaaagagg tgatattata cctgtaatat gtggttcaac
     5581 tataaataat ataggcacaa aggaaatatt agatacaata tcaagttatt tagaacctat
     5641 ctttacagag gaaagcaaac catttagggg attagtattt aaaactatgg ttgacccatt
     5701 tgttggaaag atgtcatata taaaaattac tgagggtgta ctttctaagg ataaagatgt
     5761 ttttaatata aataaaaatg taaaagaaaa aatagctaat atatatacat tgagaaatag
     5821 tgaattagta gaaatagaaa aagctaaagc tggtgatata gtagttataa ctaaagttaa
     5881 ttctctaaaa acaggagaca ctatatctgc agataaagat gcagaagctt tagaaaagat
     5941 agattttcct aaaccacaaa tatattatgc agtaactcct aagaataaag gtgatgaaga
     6001 aaaagtagca tctgtattaa ataaactagt agaagaggac cctacattac attggtatag
     6061 aaatacagag acaaaacaag cacttttagg aggtcaagga gaacttcata taaaaacaat
     6121 taaaaataaa atgaaagata agtttggtgt tgatgttgaa ttgaatgacc ttaaagttcc
     6181 ttatagagaa actataaaag gaacagctga tgtacaagga aaacataaaa agcaatcagg
     6241 tggtcatggt caatatggag acgtaaaaat aagatttgaa agatgtgaat ctgattttga
     6301 atttacagaa gaaatatttg gtggttctgt accaaaacaa tatataccag cagttgaaaa
     6361 aggtttaaaa gactctatgc aaaaaggtat attagcagga tatcctgtta caaacataaa
     6421 agctacgctt tatgatggtt cataccatga tgtagactct tctgaaatgg cctttaagat
     6481 ggcagcaagt gcagccttta aaaaaggtat ggaagaagca cacccaatac tactagaacc
     6541 tataatgaaa cttaagataa ctgttccaga agaatatatg ggagatgtca tgggtgatat
     6601 aaataagaga agaggaaaaa tatttggaat ggaaccagat gacaaaggga aacaaataat
     6661 atttgcagaa gctccacaag cagagacatt taaatatgca atagatttaa gagcaatgac
     6721 acaaggtaga ggatactttg aaatggaatt agagagatat ggagaggttc catcacagtt
     6781 tgcagaaaaa ataattgggt tagctactgc aaagtaatga acaaaataaa tagaaaaata
     6841 attaatatat attattaaaa atatttttag ggttttaact aggtataggt ttatgttagg
     6901 taaacttata cctagttttt atacattttt gatgaataaa aaaatatata atactttctt
     6961 aaatatttta ataaaaagaa agtatttttt tattattatt tttacaaatg tttagtaata
     7021 aagatgagaa ggtatattta aaatataaag tatttaaagt tctgaaatct aatcatgaag
     7081 caaaaaatta gcatttggtt atcaataaat ataataaata aaaactcata attaatgaaa
     7141 gaataaattc atatctaaat ttctataaaa aatttaaatt tatacaattt agggctttaa
     7201 aaatttaaat aataggtgta aaataatagt caaagaaagt caaaaataaa aaggtgtgtg
     7261 gtgatattaa tggcaactat gacagatata attgaaaaat ttattaaaga tttgatggaa
     7321 gaagataata gcatacaaat tcaaagaaat gaactagcaa acttgtttag ttgtgcacca
     7381 tcacaaataa attatgtctt aacaacaaga tttacaatag atagaggata ttacattgaa
     7441 agtaaaaaag gcggcggagg atatgttcaa atagaaaaaa tacgaaaaag taaagatggg
     7501 catattagag aactactaaa tgaaaaaata ggaagtcaga tatcctataa aaaagcaaaa
     7561 gaattattag aaggtttaaa agagtcggat ttgattaacg aaagagaatt aaaattaata
     7621 ttatatgcaa tagatgataa atcattgtgt atgccaatat atgaattaaa agagaaggta
     7681 aggtctaata ttttaaagaa tataataata ggattattta gtatagagga gtgataattt
     7741 atgctatgtc aaaaatgcaa taagaataaa gcatctgtat attataataa gatagtcaat
     7801 ggagaaaaaa cagagatgta tttatgtagt gagtgtgcaa aagagaatac agaaatgaat
     7861 tttaacttag atatgccttt ttcaatgatg gatatatttt ctaatttagg ttttcaacct
     7921 aaaaaagaac ttgaggaaaa gctagtttgt cctaaatgca atacaacata tagtgagttt
     7981 aagaataatg ggagatttgg atgtagtgaa tgttataatg catttagtag tcaagtaaat
     8041 ccaatgcttc aaaatataca tgggcatata gaacatacag gaaaagcacc taaaaaatct
     8101 ttttataaga taagtgtaga aaatgagatt aaagaactaa aagaagattt agatagagct
     8161 ataaaaaatg aagagtatga gttagcagct caatttagag ataaaattaa atatttaaaa
     8221 ggttctattg actaagattg gagtgatatt atgaaagaga acatagtcat gaaatcaaga
     8281 gttaggctag ctagaaattt aaataactat ccatttccaa ataaattaga taaagaatgt
     8341 gccatggaaa taatagaaaa agtaaaaaat gcgtttatta attctaactt agaacaaaaa
     8401 gaagaatttg atttctataa aattgaagat ttagaccaat ctaaaaaaat gcttatggtt
     8461 gaagaacata taataagccc agatttagca gaaaatgata aaagtgcagt tatagtaaaa
     8521 aaagataaaa ctataagtat aatgataaat gaagaagacc atataaggat acaaactata
     8581 tgtgatgatt taaacttaga atatgcatat agtgtagcaa atgaaataga tgatttgtta
     8641 gaatcaagtt tagaatatgc ctttaacaca aagctaggtt atctaacatc ttgtccaact
     8701 aatacaggaa caggaatgag agcttctgta atgatgcatt taccagcatt aagtcaacta
     8761 ggctatatgg atgaacttta taaaatttca tcacaaatag gcatagcaat tagagggata
     8821 tatggagaac gaacagaagc attgggaaat atatatcaaa tatctaatca acttacactt
     8881 ggaagaacag agtctaatat tatagaaaat gtaagtggac ttacaaaaga tgcaatttca
     8941 aaagaaataa aagctagaga aatattgcaa aaaaaattag gtataaaact agaagataaa
     9001 atatttagat cgatagggac acttgaaaat tcaagagtaa tgagtagcgc agaggcaatg
     9061 agccatctat caaatataaa aatgggaata gaaatgaact atatagataa actagattta
     9121 agggctatag aacaacttat gataggtata caaccagcgc atcagtcaat aatgtataag
     9181 agtgatgatg ttgagaatag agatataaat agagcaacat atattagaga aactttggaa
     9241 aaattaagag gagggatgaa ttgtgaactt caatagattt acacaaagag ctaaaaaggc
     9301 aattgattta gcgtttgaat ctgctaaaag tctaggacac aatattgtcg gaagtgaaca
     9361 tatactttta ggtcttttaa gagaagaaga aggtatagct gctaaagttc taagtaaagt
     9421 tggatttaca gaagcttatt tagaaggcaa aatagttgat atggaaggta agggagaaga
     9481 aatctcagaa gatatagtat taagtccaag gagtaaacaa atacttgaat tatcaggaat
     9541 gtttgcaaat aaattaaaaa caaattatat tgggactgag catatattat tagcaattat
     9601 tcaagaaggt gaaggaatag ctaataagat tttaaattat gctggagtaa atgataggac
     9661 tttagcccaa ttaacaattg atatgatggg tattagtgat aaaaatcaat acaaagcaga
     9721 gaatagttac acgggcaacc agaatcaagc agaatctaaa gtacttgata agtatggaag
     9781 aaatcttaca ctatatgcaa aacagaataa aatagaccct gtaataggta gagaaaaaga
     9841 aatacaaaga gtaatacaaa tattaagtag aagaactaaa aacaatccag tgttgatagg
     9901 agacccaggt gtagggaaaa cagccatagc tgaaggtctg gctacaaata tagccttagg
     9961 aaatgttcca gaaacactaa aaaacaaaac tttatactct ttagagatgg gttcattatt
    10021 ggctggagct aagtatagag gagaatttga agaaagaatt aaagaagttg tagatgaagt
    10081 tgttaaaaat ggaaacataa tcttatttat agatgagatg cacacaataa taggggctgg
    10141 gtctactgga gaaggctcta tagatgcttc aaatatatta aagccagcct tagcaagagg
    10201 agaaatacaa gttataggtg caactacaat tgatgaatat agaaagcatg ttgaaaaaga
    10261 ttctgctcta gaaagaagat tccaaccagt tatggtagat gaaccaacta aagaggactc
    10321 aataaaaata ttagaaggat taagagataa atatgaagct catcataaag ttaaaataac
    10381 tgatgatgct ataaaggcag ctgtagaatt atcaactaga tatatatcag acagatatct
    10441 gccagataaa gctatagact tgattgatga agctgcatca aaagtaagat taaaagaaaa
    10501 tacacctcct tcagaaataa aaaaattaga actagaaata gaaaatatag ataaagaaaa
    10561 agaagaagca gtaagatgtc aagactttga gaaagcagcc aaaataagag atgaacaagg
    10621 tctacttaaa aaacaattag aagatgttag agaaagatgg aacaagtcat ctaaacattc
    10681 agatttagtt gatggagaag ttattgctga agtagtgggc ttatggacag gaataccagt
    10741 taataaaatt cttgaagaag aggctgatag acttttgaga cttgaggaaa tactgcacaa
    10801 tagagttata ggtcaagaac aagcagtaaa atctatttca aaggcaatca gaaggtcaag
    10861 agcaggtctt aaagacccta atagaccaat tggttcattt ttatttttag gtccaacagg
    10921 agtaggtaaa acagaattat ctaaggcatt agcagaagtg caatttggag atgaaaatca
    10981 aataattaga atagatatgt ctgaatatat ggaaaaacat gctgtgtcaa gaatgatagg
    11041 ttcacctcca ggttatgtag gtcatgatga aggtggtcaa ttaactgaaa aagtaagaag
    11101 aaatccatat tcagttatct tatttgatga gatagaaaaa gctcatccag atgtatttaa
    11161 tattctgtta caaattctag atgatggtag actaactgat tcaaaaggaa gaactgtaga
    11221 ttttaagaat actattgtaa taatgacatc aaatgttgga gcatctacaa ttggtagaca
    11281 aaaaacttta ggatttagta tagctaaagg agacgaagaa gaaaaatctc aatatgaaaa
    11341 aatgaaagaa aatataatgg gtgaattaaa acaaagattc agaccagagt ttttaaacag
    11401 aatagatgat ataattgttt tccactcact aaatgaaaat catatatcaa aaatagtact
    11461 tttaatggca gcgaaactac aagagagatt aaaagaaatg gatataaaat tagaaatgag
    11521 tgatgaggct gttaaattaa tttctaaatc tggatttgac ttagaatatg gagcaagacc
    11581 tcttaaaaga gctttacaaa aagagttgga agatgagcta tctgaagcaa tcttaaaagg
    11641 taatgtgaaa aagggaagta atgtagtagc aaaagtcaaa gatgaaaaaa tagtttttga
    11701 aactaaataa tttaatagag ttgcatttta aaatattgca aatataagtt ttataatcta
    11761 aacaaaattt taagggcaat gaatctataa taattcattg tccttaatta ttttatttaa
    11821 tctttacata ttgtctttca gatatgctaa aattatagta tagaataaaa aattaaggat
    11881 gataaaagta tggcaaaaat aaaaacaaaa tatgtatgtc aatcttgcgg atatgaaaca
    11941 gctaaatggc ttggtaaatg tccagaatgt acaaaatgga atacatttgt agaagaaata
    12001 gaccaaaaaa gcaccaaaaa agaggtcttt ataatagata aatcttcatc taaaccagtc
    12061 agtataaact caatagagag taaagaagaa gagcggttta caacagatat aaatgaatta
    12121 gatagagtgc ttggaggagg tatagttaaa ggctctttag tgcttgttgg tggtgaccct
    12181 ggtataggta aatcaacact tttaatccaa gtatctagta atgttgccaa tttaggaaaa
    12241 actgttttat atataactgg agaagaatca gaatctcaaa taaaaatgag agctaaaaga
    12301 ttaggtatta actcagaaaa tttatatata tttgctgaaa ataatttaag tataattgaa
    12361 tcttatttag aaagtgtaaa tccagaatta ataattctag actcaattca aactgtcttc
    12421 agtccagaaa tatcctcggc accaggaact gtcagccaaa ttaaagaagg tacttcaaaa
    12481 ttcatgaaaa tttctaaaaa aatgggaatt tcaacgttca tagttgggca tgttacaaaa
    12541 gaaggttcac tagcaggacc aaaattatta gagcatatgg ttgatactgt tctatatttt
    12601 gaaggagaaa gatataatac ttatagatta gtaagagctg ttaaaaatcg atttggttca
    12661 actaatgaac ttggagtgtt tgaaatgagg gatttaggat tagtagaact tgataatcca
    12721 tctaaaattt taatctctga aaaaccaaaa gatgtagcag gttcagtaat aatatctact
    12781 gtagaaggta cgagaccaat gttacttgaa ttgcaagcat tagtttctcc tacaagtttt
    12841 ggtataccaa aaagaacatc tacaggagtc gattacaata gagtaggtat gttattagca
    12901 gtattagaaa aacgtgttgg tttgcaaata caaaatcaag atgtctatat aaacatagtt
    12961 ggaggaataa agataaatga accctcaatt gatttaggga tagccatttc tgtagcatct
    13021 agttttagaa atataccgat agatgaagat atagctgtta caggagaagt gggacttaca
    13081 ggagaagtta gagcagtaag ctttatagaa aaaagaatag ctgagtgtaa aaaacttgga
    13141 tttaaaaaga tagtagttcc tagaagtaat tatgatgttg taaaagagac caaaggcata
    13201 gaaatatggc cagtagataa cttaagacaa gctataaata tagtacttgg gaggaatcaa
    13261 taaatatgga gaattttcta gataataaaa atatgctata tgcattaaaa atgatatctc
    13321 ctggaactcc acttagatta ggtctaaaca atgtactaag agctaagact ggtggattaa
    13381 ttgtaattgc aacaaacgaa gatgtaatga aaatagtaga tggaggattt gctataaatg
    13441 cagaatattc accatcatat ctatatgaat tagctaaaat ggatggagct atagttttaa
    13501 gtggtgatgt aaagaaaata ttatttgcta atgcacaact tatacctgac tattttatag
    13561 aaacatcaga gacaggaaca agacatagaa cagcagaaag agtagcaaaa caaactggtg
    13621 ctatagtcat aggaatttca caaagaagaa atgttataac agtttataga ggaaatgaga
    13681 agtatgtagt cgaagatata tctaagatat ttactaaggc aaatcaggct atacaaactc
    13741 tggaaaaata taagacagta ttggaccaag ctgtaacaaa tttaaatgcc ttagagttta
    13801 atgatttggt aactatttat gatgttgcat tagtcatgca aaagatggaa atggtaatga
    13861 gagttacaag tataattgaa aaatatgtga tagaattggg tgatgaagga actttagtaa
    13921 gtatgcaatt agaagaatta atgggtacaa ccagaataga ccagaaatta atattcaaag
    13981 attataataa agaaaacaca gaaataaaag aacttatgaa aaaggtcaaa aatttaaatt
    14041 cagaagaact aatagaattg gttaatatgg caaaactatt agggtatagt ggtttttcag
    14101 aaagtatgga tatgcctata aaaacaagag gttataggat tcttagcaaa atacatagac
    14161 taccaacagc aataatagaa aacttagtaa attattttga aaactttcaa caaattttag
    14221 atgcatctat tgaagaatta gatgaggttg aaggaatagg tgaaataaga gcaacatata
    14281 taaaaaatgg actcataaaa atgaaacaat tagtcttatt agatagacac atatgatgaa
    14341 ttttaaatga attttactac ttttttcttg aatataatat acactttggt ctataataga
    14401 taagtataac tagggggtga agcattgata aggaaagtaa caagaatatt gtttatttta
    14461 cttggattta caataggtat aacaacctat ttaacattaa tgaaagattt tgaaatatta
    14521 acatttggaa aagaaacata tggttatatc gcagctgtag tagcaggtat aataatagcc
    14581 attttaggat atcttataga accatgggtt gtaaataaag taaaagaaat tgctaaaata
    14641 gtggataaag aattgtcaaa atatcctcag actgatatat tgttagggtc tatgggtctt
    14701 atagtaggat ttgttattgc gtatttatta agtggattag taaatagaat accaatagta
    14761 ggtggaatac tatccttact attatattta ttcctaggat atcttggaat gaaagttgcg
    14821 cttaaaagta aaaatgattt atttaatatt ggaaaactag gaagattagc aaatcctatt
    14881 aaggataaag ataaggataa agaaaataaa aaagaagtaa aagccattcc tccaaaagta
    14941 ttagatacaa gtgtaataat tgatggaaga atagctgata tttgtaagac tgggtttata
    15001 gaaggaaaac ttattattcc tgcttttgtt ttggaggaac taagacatat tgcagattct
    15061 tcagatgatt taaaaagagt aagaggtaga agaggtctgg atatattaaa tataattcag
    15121 aaagaattaa atatagaagt tgaaataagt gagagagact ttgatgatat agcagaagtt
    15181 gatagtaaat tattaaagct tgctcaggtt ttaaatggaa aagttgttac aaatgattat
    15241 aacttaaata aagttgctca attccaaggt gttgaagtat taaatataaa tgagttagct
    15301 aatgctataa aaccagttgc tataccaggt gaagatatgg ttgttcaagt ggttaaagaa
    15361 ggaaaagagg ctcaacaagg tgttgcatat ctagatgatg gaactatgat agttgttgat
    15421 ggaggaagaa aatatatgaa tgagactata aaagtactcg ttacttctgt tcttcaaact
    15481 cctgcaggta gaatgatatt tgcaaaacct aaaaattaat atgttcaaag aaacctataa
    15541 tttgggctgt ttattttaaa tagatggtcc aaatttattt atttataacg ataatgttta
    15601 atgtattctt aaagatgggg atttaaatca gaaagcaggg agaatttatg agaaaaaaga
    15661 ttatatcttt cttagcaaca tttatcataa tattaacatc agcaagtcag tatagttttg
    15721 cagatgatat atcaacacgt ggaaaagtaa tatttataga tatgaataga actagtatga
    15781 gtaatatgtt aagaataaaa tcattaagag aagaactaga caatagaggg tatattggct
    15841 tgatgaatat aagaggcgat aaaggaagtg atgatagaag gtcatatgct agtatgggtg
    15901 ctggtggtag agctaatgtg gctaatgaag aagatattaa ttttgaaagc tcgagtaagg
    15961 atagaaatat agtttttgaa tcagctacag gaaaaagtgc aaaaggtata aataatttaa
    16021 ctataaataa gtctataaat gaaaatttaa actttggaga gtatggttct gtattagggt
    16081 cattaggaca aagtttatct gataatggat taaaagcatc tgtattgggt aattcagata
    16141 taattgaaaa tggtcaactt ataaaaaata gaaacttatg tctaactgca atggatgaat
    16201 atggaagaat acctaatgga aatgtagata ctataaataa aaaagactta tctatgcctt
    16261 atggaatatc aactgattat gataaattga ttgtagagac taaagaagct tacaaaaata
    16321 atgatgtgat ttttgtggag cttggagaca catatagatt agatttatat aaaccaaatt
    16381 taaatgaaaa aacatatgag agtatgaaag atagcataga aaaaaatata gatatatatt
    16441 taaaaaatat attttctatg gttgaagaaa atgacactgt ctacatagca agtgcatttc
    16501 caagtgattt agattataaa aataaaagaa gactttctcc aataataaaa ttaaatggag
    16561 aagggaaagg tatattatca tcttcaacta ctagaagaga aggtattgta acaaatttag
    16621 atgttggggt tgaaatatta gacaacttta atataaaaaa tcaaaatatg gttggaagaa
    16681 aatatgaact tattaacaga gatgataata aagaattttt gatggatgaa tatcaaaaga
    16741 tagtatctat ttcaagcata aggtctacaa tactgaatgg ttttgtaagt atagttttct
    16801 tgtcatggat agttgctatg attgcaattt tatttagaaa gcatatatca aaaaattata
    16861 aagaaacaac attttttata ttaaaggaac ttttaaaaat aggaatagta atgccactgt
    16921 catttatgat aacaccaata atgaatttca aaacaccatt agcaatatct ttaggaataa
    16981 ttataataac acttactata tatcttataa gtaaagtttt aataaagaac gatttaaaaa
    17041 acatgctgtt ttttactgga ttaaccatag taattatggt tattgatgct gggtttggct
    17101 catatttaat gaaaagcaat gttatgagtt atgattgtat aattggagct agatattatg
    17161 gagtaggaaa tgagtatcaa ggtgtggcaa tcggtagtgc aatatttaca tttgcaattt
    17221 tacttacata taaaaatata ccaaagtggt ctataatagt tttttctttg gttatcttaa
    17281 ttacaagtgc atctccaatt atgggagcaa atgttggaag tgctatttct gaatgtgttg
    17341 catttttact atttatacta ttgatatata atgtaaagat agatttcaaa aaaatcgtat
    17401 tattaggtat agcagtagta tttgtattag gagtttttgt agcaatagat atgattttgg
    17461 gaagtaattc acatttaggc atgtttgtaa aagaaattta ctttaatgga ccaggagaaa
    17521 taatacaaac atttagtaga aagatagaga tgaatttaaa gctagctcaa accagtgcat
    17581 gggtaaatat actgttaact ggaataggtg taattttagt tcttatgatt aatcagatta
    17641 gatactttaa gcaactgatg gatgagtatc caattgtatt taaaggattt atagcatcaa
    17701 tagcaggatg tttagtaact cttttagtga atgactctgg gattgtgtca tcagctacag
    17761 cctttattta tgtaattgta cctatgataa cattaagtat aaatctcaca gcattaaaag
    17821 aataagtact gtatgaataa tatgtaaata ttaatacatt aatttaactt ctttatttac
    17881 aaaataaaga agaaagttta taaaaaataa attataataa aaaagagttt atctcaaaat
    17941 tgattattct aatcaaattt taagataaac tttttttatt ataaagataa ataacatata
    18001 acctcatatt ttaggtagat ttttttctta tatgtttagg agtgcattta aatttttcct
    18061 taaaaattct gtaaaataat tttgtattag taaatccatg agcttctaat atactgcata
    18121 aggtatcatt tgtgttaatt aaatctttat aaatatgaga aatacgcaca tcatttaaat
    18181 actctaagta agtttgtccc atatactgtt taaattttct acaaaaatat tctggttgta
    18241 agtgtgctac cttagcgatt ttgttaatag aaataggcat tttgtaatta atctttgtat
    18301 attctaaaac tggttcaaat tttgacaaat caagtactgt ttttttcata tttttattac
    18361 ctacagatat tttaaagttt gtatataatt caaataaaag ttcaaataat aagcttgtaa
    18421 agagcagatt agctgcagga ggagaactaa gtttaatttc tctcatgttt tctaatataa
    18481 gtttaacttt acttgaattt tttttatagt tattgtcatt ggcattaacc ttaaagtcaa
    18541 aatagcaatt tttaaaatca gggatatatt tgtttagaaa agacaatggt acttgcaata
    18601 atatagaggt attttgataa atacatctag ttgagtgaat aattccagaa ttaatgaaca
    18661 tacactcatt agcttttaaa ttataagtgt aaccctccat gttaatttgt aaatcaccag
    18721 aagttatata aattatttct aatgagttat gccaatgatt tgctacataa ctaccactat
    18781 catcaaatag tttgaaatta acatctaaat tatcaatagg ttcaattatt tcatgtgaaa
    18841 aattatttct gttcataata atatcctcct tataatttta aattataaat agtaaattta
    18901 taatgttcaa tattaaaaag ataatataga ctaataaatt agataataaa catacttaag
    18961 aaaacagata aaatcaaata taataactgt atattaaaat aacttaaaaa aattatttta
    19021 ttataagtgc aaaatatacc tatttaaata agataagagg ggaggatttt atgtgtatat
    19081 aaaaggtgta aatttaggag gttggttagt tttagaaaaa tggatgacct caagtttatt
    19141 tgaaggcaca gaagctgaag atgaatacta tttaccaaga cagctttcaa gagaggcata
    19201 tgaatctaga attaagactc atcgtagtga atacatcaca gagagagatt ttgcaacgat
    19261 taaatctatg ggatttaatt cagttcgtat accagtacca tactttattt ttggagattg
    19321 tgaaccattc ataggatgtg ttaaagaact tgataaagca tttgcttggg cagataagta
    19381 tgggcttagt atattgatag acttacatac agttccagga agccaaaatg gatttgataa
    19441 tggaggaata tcaggtatat gtagctggtc acaaaatcca gaatatgtag cgtttacatt
    19501 aaatgtatta gaaagacttg caaaacgtta tgggatgagg catgaattgt atggaatcca
    19561 aattttaaat gagcctataa cagaaagaat gtggaacata atgaatgttc caaatcggtt
    19621 taaggctgta gataaggaga tggcaagggg gagtaaacct aattcattag agtttttacg
    19681 tgatttttat ataaaagcat ataaggtaat gcgtccttat atgagagagg aaaacgttat
    19741 agtatttcat gatgcatttg aattaaaagc atggaaagac tttatgagag aggaagaatt
    19801 taaaaatgtt gttctagata cacaccaata tttgatgtta gctgaagcag atggatgtga
    19861 acaaagtatt gatagctatc tcaaatatat tagagaaaat tatgctaaag atattttaca
    19921 aatgcaaaaa tattttcctg ttatatgtgg ggagtggagc ttatttaatt catatgcttg
    19981 tggtatagat acaaatggag gtcaatcacc tctaaatggg attgaatcaa atatagataa
    20041 attatcaaaa gacgataaaa gagaattata taggaagata gcaaaagcac agcttgatgc
    20101 atggagaaat ggaagtggtc actactattg gaattataag ttattactag atacagttaa
    20161 tgaagaaggt tggataggat gggatagttg ggacctaggc aaatgtgtag ctcaagaatg
    20221 gtatcctata gaatattaaa ctaaaattgg aggaaaagat atgattaaaa accctatact
    20281 tccaggtttt aatccagatc cttgtatttg tagaaaggga gatgattatt atcttgtagt
    20341 ttcatctttt gaatggtttc caggtatacc tgtttatcac tctaaagact taaaaaattg
    20401 ggagttatat actcatattt tgacagatga aacaaaaata gatttgaaga agcttccttc
    20461 atctaaagga atttgggcac cttgtttgac ttattgtgaa gaagaagatt tattttacat
    20521 agtttatgga attatgaact ctatgaatgc aagatatttt gatgttgata attatttaat
    20581 tacatcaaaa gatataaagg gagagtggag tgaaccagta tatctacact catcaggttt
    20641 tgatgcgtct atttttcatg atgatgatgg taaaaagtgg attgcatcat tagactggga
    20701 gactagagaa ggatatgaaa aacctggtgt tatatgttta gtggaatact gtacaaaaaa
    20761 gaaagaaata gtaggatatc caaagagaat atggtcaggg ggaactgata gaggttgtat
    20821 tgaagcacca catataacaa agcgtggaga ttactattat ataatgtgtg cagaaggtgg
    20881 aactggatat ggtcatagtg taactatggg aagggctaaa aatatatggg gaccttatga
    20941 aaaagattca atgaatccaa ttgtaacttc aattccaggc gatttttatg aaagacatga
    21001 ccctgaccat ctaaagccta aatactataa tccagaatca aaacttcaaa aatctggtca
    21061 tggaagctat atagaaacaa catcaggtga agtatattta gttcatctaa catctagacc
    21121 atttgtacca gagttaaggt gtactttagg tagagaaaca gctattcaaa aaatgaaatg
    21181 gacaaaggat aattggcttc gaatggaaga tgaaagtaat ttggcaaaag aatacgtatc
    21241 agaaagtaaa ctagaagaac atttagtttc atctatacca agttttgatg actttgattc
    21301 aaatgaatta ggtttacagt actatgctcc taggatttca ccattatcat ttgcagatgt
    21361 taagtctaga ccaggatatg taaggattag aggacaagaa tcaagaacat cattaaataa
    21421 agtgagcata ttggcaagaa aattaacttc agtatatgca agaataacca ctaagatgga
    21481 gttttaccca gaggtacatc agcatagtgc gggtttgata atgtattatg ataatatgaa
    21541 ttatataaat ttaagaaagt attatagtga aacattgggt caaagtgcac tatcaataat
    21601 acatcttgaa aatggagaga aaacggaatt tttaaatact aggataccaa taaaagatat
    21661 accaatatat cttcgtctgt atatacaagg tcgtaagtca tattttgaat ggagttatga
    21721 tgaaaaaaac taccagagaa taggaaaggt atttgataca actaagtttt cagatgagta
    21781 ctgtaaatat ggagaattta caggtacgtt tataggatta acttgtgcag atcgtgtaaa
    21841 gcataaacac tatgctgatt ttgatttttt tgaatatata gtagatgaat caaaagatgt
    21901 cgattaataa aatcattact aaaattttca gagcaaaggt aaatcttatg ctctgaaata
    21961 agaaacatta gaaggcaaat cttacaaaaa ggagtatggt attatgaata cagaagttaa
    22021 tgttaaagca actacgatta aatatgaaaa gatttcattt tttgaaagaa tttcttatgg
    22081 ttgtggggat ttggggtgca atatcatata ctcagctatg tcagcatttt tgctgtttta
    22141 ttatactaat tatgcagatg ttagtgcagc agctgtaggt agtattatgc ttgtatctag
    22201 gatactggat gggtttagtg acttaacaat gggaattata gtggatagaa ctaaatccaa
    22261 atacggtaag gctaggcctt ggattttgag aatggcgatt ccttttgcta tagcagcagt
    22321 attattattt tctgttccat caaatcttgg tatcacttct aaattaattt atatttttat
    22381 tacatataac ttagtttcta ctgttattta tacagcaatc aatgtaccct atgcaactct
    22441 aaattcactt ataactcaaa accagtatga aagaggagta ttaagtatat ttagaatgat
    22501 attagccact tgtggtacct tactaataaa tggacttaca ctacctctag ttgaatactt
    22561 tggaaataat ttatcagcat ggactaaaac attctttgta tttggaatag catctataat
    22621 ggtatttttt ataacattta ctggaaccaa ggaaagagta aaagcagtta agcaagatag
    22681 gaatgaagta ataccattta aaataggtat taaatcttta tttagaaata agtactggat
    22741 acaaataaca ttatgtttag tttgtatatt tattgtattt gcgataaatg gtggttcatc
    22801 cgtatattat gcaaagttta ttttgggaga tgaaaaatta tttggtccta taaatatggt
    22861 ttcaaatata tcccaaatta tagctatgtt tatggttgct ccttttataa aaaaatttgg
    22921 aaaaagaaat gtattaatag taggttcaat aatattaata tcgtcaaatg ttatgtttat
    22981 aatagttgga caaaatcata taggagtaat atttgcaagt gctataaagg gaataggaag
    23041 tgctggaata gcatcaacaa tgtttgctat tgtttcagat actattgaat atggagaatg
    23101 gaagactgga tatagaactg aggggcttat aaatagtgca tctagttttg ggtttaaagt
    23161 gggaaatgga ttaggttcag caatattagg tgcagtatta tcaattggtg gttatgtagg
    23221 aacatcagct actcaaagtg atttagctat agtatcaata aaagtatgtt ttatatacct
    23281 acctatattt ataacaatat tacaaattat cataatgtct ttttataagc ttgataaaga
    23341 atatagtact atacttaatg aattaaatac taaataatga aaaagtttct tataaagtct
    23401 taagtttaat taaggtctat tgtaaatgtt ccctataaaa actattatat atttatgatt
    23461 attgaagaat ttttagagaa gcgaataata aaaatataag aagactttaa atgatgaaat
    23521 ggttggtttt ttagaaatga tttaataagt tattgttatt taaagcatta taagtggaca
    23581 attaaatttt aatttatgga gatgatattt aacaattaga agtaatatat aatatgcact
    23641 aagaagcaat ttttcaacta tttatgaagg tggtggtaca agaaaagtat cacctttttt
    23701 ttgttataca aaaaaacagt tgacttttta tatgaacccc ttctataatg ttactgaaat
    23761 taagtaaaat gattgaacaa atgtaaagat aattgaaaag cttgattttg gaggaaagca
    23821 aatgaaaaaa attggagact taagattaat gatgaagtgt tgttcacttt attacgaaga
    23881 taatttgaat caacaggaaa tagcaaatca attgggaata tcaagaccaa caatatcaag
    23941 aatattaaaa gaagcttttg aacaaggaat agtaaaaata cagatagttg atgttttgaa
    24001 aaatgattac caaaaaatag agagaagttt ggagagaaaa tataaattaa aagaagtaat
    24061 agtagtagat gataaacagg atgcactaac acaaaaacaa gaactagcaa gagctgtatc
    24121 tgaatattta actagagtag taaaggaaaa tgatataata ggtgtttcaa taggaacaac
    24181 actaaaagaa ataccaagat atgtggaaaa aagtaactgt aaaaatgtta catttatacc
    24241 tctattagga gggattggag acaatgaaat agatattcat gcaaatcaaa tagcagtaag
    24301 tttagcgagg gcttttggag gtgattttaa attattacat gctccagctg ttatgtctga
    24361 cttgtctaca aaagagaaac tttgcaaaga cgaaaaaatt aaagaagtac tagatttaat
    24421 agataaaaca actatagcaa ttgtgggtat aggaaatcct atgagtttaa actcaacaat
    24481 aatggcttct ggatacatga atgaagcaga tatagaagat ttaaaaaaat acaactcaat
    24541 aggtgcaatt tgtttacaag cctttgataa agaaggaaaa acttctatac ttgaatttaa
    24601 tcaaagagta ttaggagtga aactggaaga tttaaaaaag ataaaaagaa caataggtgt
    24661 cgcttcagga gatgaaaaaa tagaggcaat aaaggcatca ttaaaagcga aatttataaa
    24721 tagtttagca attaatcaca gtttagcact taaattatta gaagattgtg actaatagaa
    24781 agatagataa aagttaacag gagggaatgt atatgtcaat atcaaaagaa acattgcttg
    24841 aaatgtataa gagaatgaat caggctagaa aatttgaaga gaaagttagt tggttttttg
    24901 caagaggtat ggttcatgga acaactcact tatctgtagg tcaagaagcg tcaagtgtgg
    24961 cggctgtaat ggctttagaa aaaggagatt tagtatcatt aactcataga ggacatagtc
    25021 aatttatagg aatgggaata gacctaaata aaatgatggc tgaacttatg ggtaaagaaa
    25081 ctggattttg taagggaaaa ggaggctcaa tgcatatagc agatattgag tcaggtaact
    25141 taggagcaaa tggagttgta ggtggaggtc ttacaatagc tccaggagct gcacttacac
    25201 aacagtataa aaaaacaggc aaaatagttt tatgtagttt tggtgatgga gcatcaaatg
    25261 aaggtacttt tcatgaagga ataaatttat cttcaatatg gaaattgcca ataatatttt
    25321 actgtgagaa taatttatac ggtatgtcaa caagcataaa acgtcatatg aatatagaaa
    25381 gtattgccac tagagcagct tcttatggaa tagaaggaat atcaatagat ggatataacc
    25441 caatagaagt atacgaaaca gtacaaaaag ctgctgagaa gtgtagaaga ggagaaggac
    25501 ctgtattaat tgaaagtaga acttatagat ggttaggtca ttcaaaatca gatgcaaatg
    25561 tatatagaac aaaagaagaa atagaatcat ggaaagcaaa agaccctatt gaatttttaa
    25621 aaaattatct tatagaaaat aatctatcta atgaagatga attagataag attcaagaat
    25681 ttgcaaagca atcaatagaa gatgcagtag agtttgctca aaatagccca aatccaaaaa
    25741 tagagtcttt attagaggat gtatatgcag actaagaatg gtaaaggagg aaaataaaaa
    25801 tgagtacaag ggaattaaca tatgcacaag caataaagga agcaatgtca gaagaaatga
    25861 gaagagatga aaatgtaata tttatgggag aagatatagg aatatatgga ggagcatttg
    25921 gtgtatcagt tggtatgata gatgaatttg gaccagaaag agtaagggat actcctatat
    25981 cagaagcagc tatagcagga gcggcagcag gtgcagcagc aactggctta agacctatta
    26041 tggaagtaat gtttatggac tttgtaacaa tttctatgga tgcaattgta aatcaagcgg
    26101 caaaaatgag atatatgttt ggaggaaaag cacaagttcc aatggttgtt agatgtccag
    26161 gaggttctgg aactggttca gcagagcaac attcacaaag tttagaagct tggttttgtc
    26221 atgtaccagg agtaaaagta gttgcacctt ctacaccagc agatgctaag ggattgttga
    26281 aagcagctat aagagataat aatccagtca tatttgttga gaataaattg ttatacagaa
    26341 aaaaaggttt tgtgccagaa gatgattatg taattgaaat tggaaaggca gatattaaaa
    26401 gagagggtac tgatgttaca gtaattactt atggaagaat gttacaaagt gttgaagaag
    26461 cagcagagac tctatcaaaa gaaaatataa atgttgaaat tatagattta agaactttat
    26521 atccattaga taaagagact atagtaaaga gtgtatgtaa aactgggaga gttttaattt
    26581 gccatgaagc agctaagact ggtgggctag gtggagaaat atcagccctg ataacagaaa
    26641 gtgaatcatt tgattattta gatgctccag taaaaagaat ttgtggaaaa gatgtgccaa
    26701 taccatataa tccagagtta gaaaaagcag ttgtcccaag agttgatgaa atagaagaag
    26761 caataaaatc tttaattgtt agataaggag ggatagatat ggtggcaaat aaaataaaag
    26821 ccacaccagc agctagaagt caggcaagaa aagacaatat aaaattagat aggctgattg
    26881 gaagtggaga aaatggaagg attcatttag tagatgtgtt aaattattta aaagataata
    26941 aagcaaatac tactccttta gctagaagaa tagcagaaga tttaaatata gatttagaaa
    27001 ctattgtagg tactggatat aatggaaaga taagaaagtg tgatgtggaa aaattaactg
    27061 caaaagaaac tattgtatca actaatacat ctaaatctag tgagaaaaaa gagctgaaaa
    27121 ttgaaaatga aaattcaagc atgtttaaca cagtagaagg aatatttgaa aagccaaatc
    27181 caatgagagc cactgtagca aaacgaatgt cagaaagtta ttttagtgct cctgtattta
    27241 cattcaatat agaagtagat gctacagaat tgaaggtact tagagcaaag ttaatcgaca
    27301 cagtaaaaga atcaactgga gtaaaattaa ctatgacaga tttaatagta atggcagtat
    27361 ctaaaatact tccaaatcat caagccttaa attcagcatg gacagatgag ggtatattta
    27421 gatataaaga tgtaaatata gctattgcag ttggtttaga tgaaggctta tatgttccgg
    27481 tagtaaaaaa tgcaaacaaa aagtctttaa aagaaatagc aaaagaaagc aaagaacttg
    27541 cggaaaaagt aaagacaggg aaacttatgc cagcagacca agaaggtaat acatttacaa
    27601 taagtaatgt tggaatgtat ggtataacta catttacacc tataataaat atgccttcaa
    27661 gtgcaatctt aggggtaggt gctacacaag ataagtttgt tccagtaaat ggagaggcta
    27721 aaataaaacc tataatgaac ttatcattaa catcagacca tagagtaata gatggaacag
    27781 tagctgcaaa attcttaaaa gatttaaaag aattgttaga aaatccttta tcaatgcttg
    27841 tataggtttt gatattttgt tactgatata aatagtttga atagattata ttattataat
    27901 tgtttcagta aatttaaagc ttttatatat taagaattat ttttaacagt aactatatgt
    27961 gaatatgatt tgcttaatta aaatataaga aaataaatag gaggagagcc tatgtcagta
    28021 gaagtaataa tgccaaaagc aggagtagcc atggaagaag gtactatagt atcttggcta
    28081 aagcaagaag gcgaagaagt aaagattgga gaacctatac tagaaataac aacagataaa
    28141 gttaatatgg agatagagtc agaaggagaa ggtacacttg ctgtaatcat acataaagag
    28201 gaaggtgaag tattaccagt atttacagta ataggtgtaa tagcagaaaa aggggaaaat
    28261 caagaggaag taaaagctaa atatttatct ggaaatgttt caaaagaaga tacagttaaa
    28321 gagaatcaaa atatagaagt taaagaagaa aaaataaaca aaaaagagtg taatcatgat
    28381 tatgatgtag tggtaatagg aggaggacct gggggatatt tatcagcatt aaaagcagct
    28441 cttttaggtg gaagagttgc tttagttgaa gaaaatatac taggaggtac ttgcttaaat
    28501 agaggttgta tccctacaaa gacttatata aaaacagcag aaatattaga agaaattgac
    28561 caattatcaa agagaggtgt aaaagtaact gtagataaag aacaggacat taagaaggcc
    28621 ataaaatata aaaatagagt agttaaaaaa cttacagctg gtgttggcgg attattaaaa
    28681 agtagagatg tagatgtgtt taatcttaaa gctagtgtta aagaagagca taaagtaatt
    28741 ttatcagatg gaaaagtttt agatacagaa aatataataa ttgctacagg ttccaaagta
    28801 aggatattac ctataaaagg aatagaatca aatttaataa taactagtac agaagcatta
    28861 gatttggaaa cagtgccaga agaattagta ataattggtg gtggagtgat tggttgtgaa
    28921 tttgcagaga tattcaattc aagaggttct aaagtaacta tagtagaaat ggaagataga
    28981 gtaatcccaa gaatggataa agagttaagc gaatctttaa aatattctct tagtaaaaaa
    29041 ggtataaatg tattaactaa aaagaaagtt tctgaattta aagaagaagg aaataacata
    29101 ttagtgtgca ttgaaggtga agagccaata aaagcagatt tatgtctata tgctatagga
    29161 agagaagcta atctttctgg catagaggac ttagatatta aaatagataa aggttcaata
    29221 gttgtaaata gtaaaatgga aacaagtatg ccaagcatat atgcagtagg tgatgttact
    29281 ggaggtgtaa tgttagctca tgctgctttt aaaatgggag aggtagcagc ttcaaatgct
    29341 ctaggtgtga ataaagaagt tgacttaggt gcattaccta gttgtgttta tacaattcca
    29401 gaagtagcag cagttggtat tacagaagag gatgctagaa aaaaatataa tgtaaaagtt
    29461 ggtaagttta attttgctgg aaatggaaga gctttagctt ctggtcaaga acaaggatat
    29521 gtgaaggtag tagcagatgc taaatatgga gaaattttag gtatacatat gtttggatgt
    29581 ggtgtagcag aacttataaa tcatgcagca tcatttaaag cgttagagat acctactgat
    29641 gaagcaagtg agttgatatt tggtcatcca tgtacttcag aagctttaat ggaagctttg
    29701 gcagatgtaa atggagaatg tttacactta cctaaaaaat aaatctaaac ataaattatt
    29761 aatttaagtc tattattaat attaatttat atcataaaat tttaaaacac ttacttagcc
    29821 atacccctta ttatgcaaat aatttatttg cataataagg ggtatttttt atggaaaaat
    29881 atagaatata gaatccttgt agtttttgtt gtacaaaaaa gatagtaata taaaataaca
    29941 ttatcatttt agaatgattt caattgtaat taggaaaagt gatttttttg tttttaaaaa
    30001 aagtattatt tgtaaaatat aaaaaaaaat ttcttaatat ttgaataaaa gaatagctta
    30061 atttaaatgt tattacttta taaaaaaata ataagtacaa aaaaaacaat atatggcata
    30121 taagttgcta tataaataat aaggagggaa caattataaa tgaggcaaag aataaaaaac
    30181 ttaattgaaa atgaagataa gaaaaatcct ttaacagatg aagtgatttc aagtaggtta
    30241 aatattcgaa gagaagatgt tacctttttg agaaatgagt taaaaataga agattcaaga
    30301 caaagaagaa aagttgtttt aattaaagct ataaaagata ttttaaaaga agaaaaaact
    30361 ataaataaaa atgatataac aagaagatta aacagcattg ggtttacagt atcaagattt
    30421 acagtcatac aatacttaaa agagattcaa gattctggtg acctaaaact tgataaagag
    30481 agtgatgata aaaaagaaga aataatcaat aatagagaaa ataaagatat agcatttgat
    30541 aaactcatag gtagtagtgg tagcttaagt acaattataa aactagccaa agcagcaatt
    30601 ctttatccac ctcatggtct tcatactatt attatggggc caactggtgt tggaaagagt
    30661 gagttagcag agtgtatgta taaatttgca gtagaatcat ccagattccc taagaatgca
    30721 ccatttatag tttttaatgc agcagattat tcagagaatc cacagctttt gctatcacag
    30781 ttatttggac acgttaaagg tgcttttaca ggagctgatg agaacaaaga aggattagta
    30841 tcaaaggcag atggaggaat attgtttata gatgaaatac atagattacc tcatgaaggt
    30901 caagaaatac tatttcaact gattgataaa ggtatggtca gaaagttagg agaaacaaga
    30961 ctaacacata aaatagatgt aatgattatt tcagcaactt ctgagccaat agattctcat
    31021 ttacttaata catttaaaag acgtatacct gtaacaattg aaataccaga attagttgca
    31081 agaccattaa atgagaggtt tgacattata aataatttct tcttaataga agctcaaaga
    31141 atgggagcaa acatacatat aaagtcagat gtattaaaag ctcttatgct ttacgattgt
    31201 ataggtaatg taggtcaact tagaagtgat attcaagtag cttgtgctag gggactatta
    31261 aaccaactta caaacaaact aaaagaagta aatataagca tatcagatgt acctggatat
    31321 gtaaaacaag gtcttataaa aatcagaaat tgtagaggca aaatagaaaa ttatgtagat
    31381 ggggatttaa ttatagattc aaatcttcaa ggtgagatag aaaagaaaaa tgaagatata
    31441 tatacttttc cagatgaaat atacaaactt actgaaagaa gacatattga tttattggaa
    31501 caaggtttag attttgatgt tataaataga atcattggag gagaattaga aagttgcatt
    31561 caaaaataca taaaacaagt taaaaaagtt tctattagta acaatcttcc agatataagt
    31621 ccaattgttg gaaaatatat cgtagagcta acttatgaag taatcaaaat agcatcacaa
    31681 tacctaagtt cactagaacc aaatctacat ttatgtttag cagttcacct aaaagcagct
    31741 tttgagagat taaaagaagg aaaagtaata tcaaatgctc atttgaaaga aataatagga
    31801 aattatccag tagaatattc tgtagcagaa aaggtagctc aatatttaaa ggaaagatat
    31861 aacataaact taccaaaaga agaaataggt ataatagcaa tatattttaa aatgagtagt
    31921 agaagagata tgtctgaaca aaaaaagata ggcgtacttc ttatggctca cggaagagta
    31981 gcatcttctg tatgtgaggt tacaaataaa ctattaggaa ttaatcacgc aaggtattta
    32041 gatatgccat ttgagaagaa gccggaagaa atgattgaag aagctactac aataataaaa
    32101 gatattgatg aaggtagagg tgtgattata ttagtagata tgggttcact ttcatatttt
    32161 ggagatatta tttctggaaa gactggaatt aatataagga caatatctag atttgataca
    32221 ttgctttcta tagaggttat acgaagagca gttttaccag atttaacaat agacgagata
    32281 gttgatgaag ttaaaggtat agagccacaa gtaaaagaaa aggttagtaa atgtaacaat
    32341 acaaaagtag attttagaaa acctataatt ttaacattat gtattactgg attaggggga
    32401 gcttgtaaga taaaaaaaat cttagaggaa aatattaaaa gtataactga aaaggttgat
    32461 atagaaccta taggtatgat tgaatatcca agtcttgatt tagagataaa acaaataagc
    32521 aatgataaaa atgtaatcgc catagttgga acaattgacc ctcagatagc aaatatccct
    32581 ttttttagtc tagtagacat aaatgataaa gcaaagttaa atcaaataaa taacctaatt
    32641 gatacaaatc aaattggtga aacaaataaa aaatatgaat tatcagattt aatacataaa
    32701 gaagatatat ttgtggattt acaggttaaa tcaaaagaag aagttctaaa atatatgagt
    32761 aaaaaactta gagagaaagg ttatgtgaca aaaaatttct ataaaaaagt agtggaaaga
    32821 gataacttat ttccaactga attatcagat gaaatagcaa tacctcacac agatggaata
    32881 gatgtaatta ggccagctat aagtatagcc atcttaaaga agcctattgt gtggagtaaa
    32941 agtaaagtaa aaataatact tttattagct gtagaccaaa agtgttttaa tccattaagc
    33001 actctactct catttataga aacagatgaa tttaagaaga taaaaaacat taaagataga
    33061 gattttatta gggagatgat attagatgga gtcaatgaaa ataattagta gcaatttaat
    33121 ttttaaaaat attgaagtgt ctaacaatga agatgcatta aagtttttgg gacaacgttt
    33181 gtttgacgaa cagtatgtaa aagaaagcta catacaagct gttgtagcaa gagaaaaaaa
    33241 gtatgctaca gggttaccaa cagaaatata cggagtggca ataccacata cagatatagt
    33301 acatgtaaat gagccaggaa tagcaattgg aatactgaat aaacctgtaa aatttataat
    33361 gatgggtaca gacgatactg aaattgatgt aaaagttgta tttatgttag cagtgaaaga
    33421 gccacaagaa caattgcaac tattagaaaa acttatgact atatttcaag ataagaatat
    33481 actaaataat attgttgact taagtgaaga aagtgtgagt gatttattaa actctaaatt
    33541 gaaaaattaa acatgtaaag tatattaaaa atgtaaaatt aaacatgcaa agtatgttaa
    33601 aaaatataaa aagattatta aagatttcta actatagata tctttaaaat aaaataattt
    33661 caatgggggt gactaatgtg gctaaaaaga tattagttgc atgtggaaca ggagtatgta
    33721 cttcaacaat tgctataaac aaattaaaga aagcacttca agacattggt aaattggata
    33781 tggttaatat tacacaatgt aaagtagtag aagttgcatc aaaagcacct gattatgatt
    33841 taataatttg tactacacaa gtatctagta gtataaaaac accagtgata aatggattac
    33901 cttttttaac tggtgtcgga atggataaat taatcaatga tgtattagaa gagttagaat
    33961 tataattaaa aaaattaagg aacatggtct ctaaaatcat aagttttaga gacttaaaat
    34021 taaataatgg agggtcttta tatggagata ttaaatttca ttgttggtct aggtgcacaa
    34081 gtaatgatgc caataataat atgtattttt ggtttgatat taggtacaaa actaggaaaa
    34141 tctttaagag ctggtttaac tgtgggagtt gggtttatag gtcttaatac tattatagct
    34201 ttgctaacag ataatttagg tccagctaca caacaaatgg ttaagaattt agggctaagt
    34261 ttatcaataa tagatgtagg atggccagca gcatcagcta tagcttttgc atcaacagta
    34321 ggggctttaa ttattccaat aggtcttgtg gtaaatatag ttatgctaat tactaatact
    34381 actcaaactg ttgatgtaga catatgggat tactggcatt ttgcttttac aggagcttta
    34441 gtggcagggg ctactcaaag tgtaatgtgg ggagtatttg cagcagtagc aaatatggta
    34501 attgtattgg taatggcaga tttaactgct ccaggtatag aggaatattt aggtatgcca
    34561 ggtatatctc ttcctcatgg atttacacag gcctttgttc caattgctat agtagtaaat
    34621 aaattattag atctaatacc aggtataaat aagattgaga taaatgctga tacattgcag
    34681 aaaaaatttg gattatttgg agaaccttta ataatggggt ctgtaatagg tgtaataatt
    34741 ggtattgctg cgaaatatga tataaaagga atattacaat taggtgtaac tatgggagct
    34801 gtattaatat taattccaaa gatggcagca ttattaatgg aaggattatt accagtatca
    34861 gaagctgcac aggaatttat tgagaagaga tttaaaaaca gaggcaagat ttatataggc
    34921 ttagattcag cagtaggaat aggtcatcct gttacattat cagttgcact agtgttggtt
    34981 cctttgacta tacttatagc agctatattg ccaggaaata aagttttacc atttgcagat
    35041 ttagcagtaa ttccatttgc acttgtatta atcgtaccaa ttacaaaggg aaatgtgttt
    35101 agaacattaa taataggaat aattataatt acttctggat tattaatcgc aactaactta
    35161 gctccattat ttacccaaat ggctttaaat gctagtttta aaatgcctga aggagcaact
    35221 atgatttcaa gtatttgtga tggtgcgaat ccattaagtt gggtatttgt aaaagttatg
    35281 aactataaag ttattggagg agtagttttt ggagttatag ctttaggaat ggctatttac
    35341 aataggaata gaataataaa tgaaaataaa aagctatcta tagaagaata aggttaaaac
    35401 aattttatta aggagtgtat aggttatgaa aaaatataaa tatgattcta aaagatactt
    35461 actcagtgtt acaataccag gattttttat gattttaata ttgatttatg cactgtttaa
    35521 taactataca aattttaatt tgaatatata tagtttgtta ataattgtct gtacttatag
    35581 tatattcaat acttttatat catcaagtaa tcctaaaaaa attattattg atagcaaatg
    35641 tatacatttt acctcattta tgactacaca taagtatgaa cttaaagata tagaaaagat
    35701 aagaataaga gaattttata ataaaaaaat ttatctaaaa attaatgatg gaaacctttt
    35761 taaaggtagg tattggataa gaacaaatat gtttaataat agtatagcat tatatagcta
    35821 tttcattgag ttggaagagt gcttatatcc agattcacta aaatttagaa ataaaaaatt
    35881 tgagaataag aacatataaa aataaaaaat tgaattgaag cctagcttaa tcttttttga
    35941 taatatataa gtttgaactt tatactaaat ttttagaatt ttcaatcaag ataataacat
    36001 aatagctaag caattagaac acaattaaga tgtataaggc atgtatatga tgaatgggag
    36061 gatttaatta atgttattag agaaattaag aaaagaagta ttacaagcat ctttagacct
    36121 tttaaactat aatttagtga cattaacagg aggaaatgta agtgggagag atgaacaaac
    36181 tggctatata gcaatcaccc caagtggaat ggattataga aatcttacac caagtgatat
    36241 tgttatagta gatgtagatg gaaatattat agatggaaaa tggaaagcat cagtggattt
    36301 atcagaccac ttgtatatat ataagcatag agaagacata aatagtataa ttcatacaca
    36361 ttctacatac tcaagttgtt ttgctatttt aaatgaacct atagaatgcg caagtacaac
    36421 tcttgcaaat gaagtagggg gttcagtacc agttgcaaaa ttttcaccac caacatctaa
    36481 aaagatggga aaatgtgtta ttgaagcaat tggtgacaaa agagcatgtc ttttagcaaa
    36541 tcatggcgta attgcagttg gtccatctgt aggacatgct cttacagccg ctgtaatgtt
    36601 agaagattca gcaaaagtat attacttagc aaaatcaatt ggcacaccag tgctactgcc
    36661 tgatgaagaa attcaaagag cgagagatgt attttttaat gtctatggtc aggataaata
    36721 aattagataa aattttaaaa gtaatatgaa aatatagata ttcaatgata ttaaggagat
    36781 ttataatgat ataataagtt taatagttaa gaagtaaaat atgaaatgta atagtatata
    36841 aattcattta agactaaaaa gaataagata aaataaaaag gagtctgtat ttctatgtat
    36901 tacttattaa acaaaagcac aaatccttac tttaatttgg cattagaaga atatctattt
    36961 ttaaatgata aatataatga tgatattata atcatatgga gaaatgaaga atccattttt
    37021 ataggtaaaa atcaaaatcc atatcaggaa gtatatcatg atgttattga aaagggagaa
    37081 attcctattt taagaagaat atctggagga ggaactgttt atcatgactt aggtaatatc
    37141 aatatgtcat tcatacaaaa agataggcaa cttcatgaga tagatttttt ggagcatact
    37201 aagtttatgc aaaagatgct ttcaacctta ggactagatg tatctataac tgaaagaaaa
    37261 gatttatttt taaatgggaa aaaaatttca ggttctgcac agtctataaa aagaaaaaat
    37321 tctctttatc atggaactct tctttacgat tcagatttaa ataaattaac taaatattta
    37381 aattcaaata aagcaactga atcaaatgca actaaatctg tttcaagtaa agttacaaat
    37441 attaagtttt tactcgaaaa agatataaat tactttttag attattgtgt tgaatattta
    37501 aaatctaata taaagaatat aaaagaactt gaattggatg aagaagatat taaaagtgta
    37561 tacaatatag gagaagataa atataaaaag atagagtgga catatggtaa aacgccgaaa
    37621 tttcaagtag tgctaccatt taataatgaa agtaaaataa atatacatgt taacagatgg
    37681 aaagtatcaa aattttttat ttcttatgat gataatgtaa ttaatatgga caagttgtta
    37741 gatttgaatt tctttaaaga agaaataaaa gagagtattt tagaaaatta tccacattac
    37801 atagatttaa tcaatttaat attttaatat aaaacctcta atttgataaa attgtcttat
    37861 atcaaactag aggtttttaa tattcttgca tattaacaac cattacaaaa ttgtaaaatt
    37921 aaaaacaaca ctattgaaaa atcaatatat atttgtttaa atatatgtgt ttttcattag
    37981 caaatagaca ttaactattt atacaactga aaatttaata tataattaat cagatggtta
    38041 aaataaaaat attaaaagtt ttaataaatg atggttaaaa ataaaatacg aggtgatacc
    38101 atgtatagtg ttataattgt tgcagcggga agcggaagga gaatgaactt agatataaac
    38161 aaacagttca taaaattaag agaaaaagaa attattgctc atacaattca agttttttat
    38221 gaaaatataa atatagatga aatagtggta tgtataaaaa aagaagaaga agattttttt
    38281 aaagaaaata taataaataa gtataacttt aaaaatataa aaatagcata tggcggaaaa
    38341 gaaagacagg actcaatata taatggttta aaaaaattag ataaaaattg tgatatagta
    38401 cttatccatg atggagcaag accatttgtc gaccatagaa taatcaacga atctataaag
    38461 gtagctaaag aaaaaaaggc tgtggttgta ggtgttccag taagtgatac tataaagata
    38521 gtgtcagatg gaacagtaaa agaaactcca gaaagaaatt tgctgtgggc agcacaaacc
    38581 cctcaaacct ttgaatataa tctcataata gatgcttatg aacaagcata taagaacaat
    38641 tattatggta ctgatgattc aatgttggta gaaaatatag gtcaaagtgt cactatggta
    38701 atgggttctt atgaaaacat aaaaataact agtccagaag atttaaatat agcagaacaa
    38761 atattaaata tggaaaaaag agatgaagtt aacagtagaa ggagaattat atgagaatag
    38821 gattaggata tgatgtacac aaattaacag aggatagaaa acttataatc ggtggtgtag
    38881 agataccaca cgataaaggt ttgttgggtc attctgatgc tgatgtattg atacatgcaa
    38941 taatggattc tattttaggt gctctagcat taggagatat agggaagcat ttcccagata
    39001 cagatgaaga atataaggga gcagatagta tgaaattatt agaacatgtg tataatctaa
    39061 taacaagtaa aggatataaa attggtaata tagacagtac tataattgct caaagcccta
    39121 agatggctcc atatattgag agtatgagaa gtaatatatc aaaagtttta aacacagaca
    39181 ttgataatat aaacataaag gcaacaacag aagaaggtct tggttttaca ggagcaaaac
    39241 agggaatagc ttcacaaagt atttgtttat tattgttgac aagtcagaat aattaatata
    39301 ttattagtaa taagtttaat ggatatcaag taataggcct atatagaata tctataatgt
    39361 atgaatttaa gtgaaattaa tataaatata aaattagcta tgataaagaa atagtaaaat
    39421 gatgaaatct tcacagagag aaaacggtgg tgagagtttt caagaggaag tctttgaacc
    39481 tgtcttttag cttaaaggta taaaaatctt tacggtagga accgttatat tcccaaaaga
    39541 gagctattca tatagctaac tagagtggta ccgcggaaat taaacctttc gtctctatac
    39601 ttgtatagag atgagaggtt ttttatattt tcaggaagtt aatattcagg aggaatctat
    39661 taatgaaaat gtcaaaaatg tttatgccga cattaaaaga aatcccagca gatgctgaga
    39721 ttacaagcca tcaattaatg gttaggtcag gcatgataaa aaaaatgact tcaggtgttt
    39781 ataaccaatt accaatgggg ttaagagtgt tcaaaaaaat tgaacaaata attagagaag
    39841 aattaaataa aaaagattgt caagaaatac tttgtgcagc cttacttcct tctgaattat
    39901 ggaaagagtc tggaaggtgg actgctatgg gtgaagaaat gtttagacta aaagacagaa
    39961 cagaaagaga gtactgtctt gggccaacac atgaagaagc attcactgat ataataagac
    40021 aagaaattac ttcatataaa caattgccac tgaacttgta ccaaatacaa gtaaaatata
    40081 gagacgagag aaggccaaga tttggtgtta tgagaactaa gacttttaca atgaaggatg
    40141 cctatagttt tgatgtagat gataaaggtt tagataagtc atatcaagat atgtttgatg
    40201 catatgtaag tatatttaat agatgtggat tggagaatag ccctgtacag gcagattcag
    40261 gagctatagg aggttctaca tcagccgaat ttatggttaa gtcagaagtt ggtgaagatg
    40321 aagttgtatt ttgtagtgga tgtgattatg cagccaatgt agaaagagca gaatcttgta
    40381 atctagcatc acaaaaagaa gaaatgaaag aattagaaga ggttcataca ccaggagcag
    40441 ctacaataaa agagttagaa gaatttttaa aaacttctcc agataagttt gctaaaactt
    40501 tagtatatga ggcagatgga aaaacagttg tagtcgttgt aagaggagat agagaagtta
    40561 atgaaatcaa agtatctaat gccataggtt ctgttataga atttgctctt gctacagatg
    40621 atgtagtgag aaaagtaact aatgcagaag taggatttgc aggtccaata ggtataaatg
    40681 ctgactatgt atttatagat aaagaaattg ttgaacaaag aaacatagtt gttggggcta
    40741 ataaaactga gtaccatata aaaaatgcta actatggaag agattttgaa ggaatagttg
    40801 gagactttag aaatgttcaa gaaggcgaca agtgtatagt atgtggtaag ccacttgaaa
    40861 tagctagagg tgttgaagta ggacatatat ttaaactagg aactaagtac tcagaatcta
    40921 tgaatgcaaa cttcatagac aaagatggaa aatcaaagcc tatagtaatg ggatgttatg
    40981 gaataggtgt tgaaagaaca gcagcagcta taattgaaca acataatgat gagaaaggta
    41041 taatatggcc tttgtcagta gctccatacc atgttgtgat agttccagca aatatgaaaa
    41101 atgaagaaca aatatcaata gctgaaaata tatataatga tttgcaagct atgggtgtag
    41161 aagttttatt agatgacaga gatgaaagaa taggtgtcaa attcaatgat tcagaattaa
    41221 taggaatacc tatgaggatt acagtaggta aaaatattaa tgaaggtaaa gtagaattta
    41281 aacttagaca taaagaagat aaagagataa ttgacataga agaaataaat gaaaaagtaa
    41341 aggcagagtt tatcaggaat aatgttaggt taggataata acttaaataa gatattgtat
    41401 agataatcaa agttgtactt tatagacacc attttatcta tatataagga tataaaatgg
    41461 tgttttttta taaaacaaat aaatgaggag gtaattaaaa tggcaaaaaa tgaaaaacaa
    41521 tttgttgaag aaataacaaa gatggaagat gattttccac aatggtacac agatgtaata
    41581 actaagactg acttagttga ttatgcacca gtaaaaggtt ttatggttgt aaagccatat
    41641 ggatatgcat tatgggaaaa gatgcaagaa tttatggata aaaaatttaa agaaactgga
    41701 cataaaaact gttattttcc attattaata ccagagagtt tattaaacaa agaagcagaa
    41761 cacgttgaag gttttgctcc agaagttgca tgggtaacac atggaggaaa taaaaaatta
    41821 gaagaaagat tatgtgtaag acctacttca gagactataa tatgtacaat gtatgcgaaa
    41881 tggttaaaat catatagaga attaccatat ctttataatc aatggtgctc agttgttaga
    41941 tgggaaaaat caactagacc tttcttaaga acatctgagt ttttatggca agaaggtcat
    42001 acattacatg aaacagcaga agaagcacaa gaagaaacaa tacaacaatt agaagtatat
    42061 aaagcgctat gtgaagaatt acttgcaatg ccagttgtag ctggtcaaaa aagtgaaagt
    42121 gagaaatttg caggtggtga aagaacatat actatagaag ctatgatgca tgatggtaaa
    42181 gcattacaat caggtacaag tcacttccta ggtcaacact ttactaaggc ttttgatatt
    42241 acttttgcag atagggaagg aaatttagct aatccatacc atacatcttg gggagcatct
    42301 acaagactta taggtggact tataatgact catagtgata acagaggttt agtattacca
    42361 ccaagagtag ctccaattca agttgttata gttcctatag ctgctaaaaa aggaaatgta
    42421 atggagactg ttgataaaat atatgctgat ttaaaagcta agggagtagc tgtagaagtt
    42481 gatgatagag ataactatac aactggatgg aaatttaatg agtgggaaat gaaaggtgtt
    42541 ccagtaagag ttgaaattgg accaaaagat atagaaaata atcaagctat ggtatttaga
    42601 agagatactt tagaaaagga ttctatgcct ttagaaggat tagctgatgc tatatgtgat
    42661 ttatttgatg ttatacacaa tgatatgttt gaaaaagcaa gaaaacatag agaagacaat
    42721 acatctatag ttgaaaatat ggatgagttt agaaaagctt tagaagaaaa gccaggattc
    42781 ataaagacta tgtggtgtgg agatgcagaa tgtgaagcta agattaagga agaaacagga
    42841 gcaactataa gatgcttacc ttttgaacaa gaaaacttag gtcacaagtg tgtgtactgt
    42901 ggaaaagaag cagatagtat ggtagtaatg gcaaaagctt actaaaatac atttaaataa
    42961 aaactggggt agaaagtatt taatacttta tcccagtttt tttgtttttt atgagtaata
    43021 aaatgtattt gtaactatgt cataagataa gtcatagata cttatattaa aaagaatata
    43081 atagagaact atttttaata attacatatt aatgaaagca aaatattttg ttatatagat
    43141 tttcaataaa gcaaac
//
LOCUS       DAEQCW010000022        43132 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.022, whole genome shotgun sequence.
ACCESSION   DAEQCW010000022 DAEQCW010000000
VERSION     DAEQCW010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43132)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43132)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43132
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.022"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            86..436
                     /locus_tag="KRO40_001219"
     CDS             86..436
                     /locus_tag="KRO40_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBH2092041.1"
                     /translation="MSAKVTNQYGNIEIDNQVIAQVVYRAAMESYGLVGLAYKSKGIV
                     ELLKGENATKGVRVEEVEEDAIAIELYVIIQYGTNISTVANNIIDRVKYVVEKMTGVR
                     VTRIDINVQGIRVK"
     gene            455..2098
                     /locus_tag="KRO40_001220"
     CDS             455..2098
                     /locus_tag="KRO40_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HBH2092042.1"
                     /translation="MIQYIDGKRLREMFISGANNLQNNKELVDKLNVFPVPDGDTGTN
                     MSLTISYALKELAKVENDNISDIGKALSKGSLMGARGNSGVILSQIIRGIAKSIEGKS
                     KLSTEDLAKAFKNGSDTAYKAVIKPIEGTILTVVRESGEFAIKTAKKEKDVVKFLSML
                     VKESNSSLERTPDLLKNLKEAGVVDSGGKGLVLIYEGMLASIKGDNIEIKNVDLDTNI
                     STSMDFAKSTTSTDDIKYCYCTEFILESSKVEDTKIRDIMMAYGDSLAVVGDDGVIKV
                     HVHTNDPGNVLQEALKYGQLLTIKIENMKLQHENTLLDVEEKKENDSEPLEEEKEFGF
                     IATSMGEGLANIFKDFGVDHIIEGGQTMNPSTEDFMNAIKHINAKNIFIFPNNSNIIM
                     AANQAKELSDKNIIVIPTKNTPQGFAALVTFNGELSEDENKEAMMNALNSVKSGQVTF
                     AVRDTVMNEIDVKEGNIIGIAEGNLLSAGDYVDEVTSNLIEKLVDEDTAIITLFFGED
                     VTESQANELRTSLEEKFEDVDVELYYGGQPLYYYLISVE"
     gene            2179..4236
                     /gene="recG"
                     /locus_tag="KRO40_001221"
     CDS             2179..4236
                     /gene="recG"
                     /locus_tag="KRO40_001221"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HBH2092043.1"
                     /translation="MDLYKDVQYVKGIGPKKADKLNKLGIFTLKDLLYYFPRQFEDRN
                     NLKKIAQLEDGEKVTIKAVISSINTFSPKEGMTLTKIDVKDETGSAKLVFFNKSYIKN
                     TFRPGDSILVFGKVKKKFNNLELTSCELEYLTNSPKNTCRFMPVYQLTYGVTNKEIMS
                     IIRTVLEDKELIIQEYMPQRIIEKYRLCSIDFAVRNIHSPSSKESLKIALYRIVFEEL
                     LILQLGLFVFKSGRNKEDGIKFETSKDLKKIISALPFKLTKAQNRALDEIIQDMNLEK
                     IMNRLVQGDVGSGKTVVALLALANCVLNGYQGALMAPTEILAGQHYISLTESLKDFGI
                     NVGLLIGSLTKKQKDTVLEQIKNNEIDILIGTHALIEDKVEFNNIGLVITDEQHRFGV
                     MQRSKLSLKGANPDILVMTATPIPRTLALILYGDLDISIIDELPPGRQPIETIAIEKS
                     KRDRAYNNLVRREVESGRQVYIVCPLVEESEAIEAKSAVELVEELRAEYFHDLRLGLL
                     HGKMKSSEKDEVMRLFKDKEIDILVSTTVIEVGVNVPNATLMIIENAERFGLAQLHQL
                     RGRVGRGSHKSYCVLIYDSKTDVCRQRMAIMEETNDGFKISEKDLEIRGPGEFFGTRQ
                     HGLPELKVANLFKHIKILKLAQQEARYILGEDNNLQLKENMALKKEIIDKFKDTLKEI
                     SLN"
     gene            4295..4849
                     /gene="rsmD"
                     /locus_tag="KRO40_001222"
     CDS             4295..4849
                     /gene="rsmD"
                     /locus_tag="KRO40_001222"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HBH2092044.1"
                     /translation="MRVISGKARGLKLNTPKNEDVRPTTDRVKESLFNMINSYIMESE
                     VLDLFAGTGSLGIECLSRGAKSCTFVDISKESIDIVKSNIKKARVESESIILNLDFKT
                     AIDKLKLQNSKFDIIFMDPPYYKNMFIEAIEKIDNSNLLNEDGIIVVEHDTNDLFPDK
                     ICKLEKTRDKKYGNTTLTFYKMEA"
     gene            4851..5348
                     /gene="coaD"
                     /locus_tag="KRO40_001223"
     CDS             4851..5348
                     /gene="coaD"
                     /locus_tag="KRO40_001223"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HBH2092045.1"
                     /translation="MENKPRKAIFAGSFDPITNGHLDIICRASKLFDELQIGVLNNPN
                     KKGLFSFDERVKLIEKSTSHLNNIKVVTFDGLLINYCQENGIGALVRGVRSGADVDYE
                     LQMAHMNRELNPDIETIILPSCTKYSFISSSLIKEVLLFDADIKNLVPKIVLEELKKK
                     TSGGN"
     gene            5352..5876
                     /locus_tag="KRO40_001224"
     CDS             5352..5876
                     /locus_tag="KRO40_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092046.1"
                     /translation="MKIDLEMIELFEQLEEIFRSASTIPFSHKCTVDKDEVLAIINDI
                     RTLIPEEVTQAVWINKERNKIISQAKQDATNIVEQAKKEAERIQQEYQDNIEELKKNS
                     EDVVKAYVESSEPVVQADQRAKDIVDRAERIANEIRIGSIEYAEDVLSSVEYNLREIL
                     EEVKRDKAELRPKK"
     gene            6220..8139
                     /locus_tag="KRO40_001225"
     CDS             6220..8139
                     /locus_tag="KRO40_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2092047.1"
                     /translation="MKERAKKILDFIIKNNNVTSQELQEKFNVSKRTIYYDILAINEQ
                     LGKSGNIKNVKHKFIFEGNLCDARKIISTEEDKFLDSDYRKTFILNKILLGEKISIEK
                     LTNEMLLSKNTVVQTITDVKKYLQTMGLRLEYKGKYKIIGDEYVIRELFLIIVQENIL
                     EINSISEEVSSFDTKGHIKLTDYSLLNLTKFVEFLNKRIRDGKTLYSYKYLNEAKKIS
                     YFSNCKELLCEEANENEQAYICTYISSLPSLNSEVKEDVVEEYVDKLIDKFEVNTAIK
                     LESKHEFKKNILRHLHSSYNRIRFKFPIRNPMLDETKYKHESLYKIIKSIIENEEEFP
                     VFEGIREEEIGFIAAYFGGYLRGSRDNGLRRNKVLLVCPNGLMVSKSLEIQLYKYIPT
                     IEIVGIVSIKQLKEVNVYYDYIITTIDIQNVNNVIVVNPLLTSSDVQLLMNKLISVKE
                     NEKYFNLELIIQAIRKNGVINNEEALKADLLNIIHKIDEGEMYQPMLKELINAERVNI
                     IKSVRDWKEAIKIASKPLLEDNSIEELYIENMIKSVEKYGPYIVLADRFALPHASSKE
                     GVNKLAMSLLIVEDEVDLLGKPVNIFMVLAAVDNTTHIRALASLSEMMYEEENVKLII
                     NGDKSSILELINKQN"
     gene            8152..8439
                     /locus_tag="KRO40_001226"
     CDS             8152..8439
                     /locus_tag="KRO40_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092048.1"
                     /translation="MKILAVCGFGVGSSMVLKMTIQKALKQLGIECEVENTDINSARG
                     ADCDCIFTSQELLNELKGTCNVDVYPVKKYMDLAEVTEVVQTFLSDKNDKK"
     gene            8572..9831
                     /locus_tag="KRO40_001227"
     CDS             8572..9831
                     /locus_tag="KRO40_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HBH2092049.1"
                     /translation="MLDFISNNILRNPSMLIGLIAAFGLVLQKKKASDVIKGSLLAAF
                     GIIIMETGTGMLVSSIAPINGAFQSISGGAVTKGLSDVTFTASYGGIIGLAMFAGLAI
                     HLMIARFTPIKTIFLTGHMLYWFPFIFVASGVEAGLNGGVLIAFAAVLSALYWSIMPW
                     LLRKYVFDVIGDDSFTLGHPSGCLALISGFVAKLVGNKEKSTEDINIPQSLSFFREIS
                     ISGGMAVFLMFIVVGIVIPGAFKDSNEFIGTYAIKQGLSFGAGLIIMLHGVRMLINQI
                     MPAFQGISEKVVPNALPAFDCPILFNYKPNAVLMGFLVAMLTSTAMILICNYFNVFNL
                     LLIPLVITSFFECGAAAVIGESQGGIRGAIIGTAIAAIFMVVLVGISAVIYSGTIQNW
                     ILIFGGNDLSLFGIISRFIGSLFGGIL"
     gene            9834..10574
                     /locus_tag="KRO40_001228"
     CDS             9834..10574
                     /locus_tag="KRO40_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH2092050.1"
                     /translation="MKFKYIDEIRRLIDIIENEEKVNMEKAVQIFVEAIESKNAIFSF
                     GASHAGILTEELFYRAGGCVLINPVFAKSLMLDTAPITHTSKMERLEGYGTALADKTP
                     IKKGDVVIVHSVSGRNPVSIEFAMKAKENKAIVICITNLSYSKSVSSRHSSGKKLYEV
                     CDLVIDNHGQKGDACVEIDGLNQKVSPTSTVIATTVMNSIIAQATQELVNKGLKNPPI
                     FYSANIDGGDELNKKIFDEYKSVIHYEY"
     gene            10897..12207
                     /locus_tag="KRO40_001229"
     CDS             10897..12207
                     /locus_tag="KRO40_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBH2092051.1"
                     /translation="MKKENKMEGIKVGMLKKLCSLAMVAIMTTTLITGCSSGNGKDSK
                     KDGEKEKLVLWMPPVENNMKEVWDPILDKFEEKNNCEVDLQIIPWDNYSEKFATAISA
                     GEGPDVGYMYAEMYPQFIESGAVEDLTNYATKEDKEQSIYIKTSEMMGGMYGMPFQAA
                     NPGVLYYNKDILEKLGEKPPKTWEDFKRICKKATQDTDGDGKIDQWGLAQGWGAKTFG
                     NLNWNWYPYLWQAGGDIFNDDLKSVKFNDKSGLEAANFLKELQAYVPEDSLSKDSNEM
                     IESVFGPGKAAFTIMLSSAATSVFDESFPDLNWGFVTGLEDKKAATFGAVDHLSLMSS
                     AKNKELAYKLIQHMLSVESMTEFHKAIPRAPITKGEPYQGDERFKEMVENDKNVYRPL
                     VVGPHGVEIYEYLWKELQTMISGDKTPKQALDDAAKYSNDLLAQ"
     gene            12305..13222
                     /locus_tag="KRO40_001230"
     CDS             12305..13222
                     /locus_tag="KRO40_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBH2092052.1"
                     /translation="MENLVREFEENSKRKKTKLNIKPYMYILPLGIILVAFYVIPIIM
                     SIYFSFTKYNIISPATFIGLENYKKLFTDETLKVSIINTIKFTVVVVPCQTILSLILA
                     VWITGKGNSKIASFAKGAIFIPVLSSMVLIGMVWRALLNGEGSIIYQVLGAFGIESSK
                     LLGDSKTALPTLMFISMWKNIGYFMVIYISAIMNLPKHCYEVAKVDGATKLQEFIKIT
                     VPLLKPTTIMVVFLGSIWSLQVFDLIYTVTGGGPGISTMSIVMHAFNLNFKNFNSGYA
                     MTVANVLFLLIAVVSILQNKLVRRDNSDF"
     gene            13238..14047
                     /locus_tag="KRO40_001231"
     CDS             13238..14047
                     /locus_tag="KRO40_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBH2092053.1"
                     /translation="MKTARRLLSDGLLLFIACASLVPFIYMLIISLKITYNSYSLDIS
                     FSTVTLQNYIDIFTKKGFAQYFFNTAIVSFSGVLLNLVFSTLAGYSFAKMDFKGSDKL
                     FLFMIMTLIIPSQVTMIPLYIIMKHLGWINSYLALIMPIPTAFGVFIMRQAILGVPKE
                     LLESAKIDGCSDFRILIQIVLPLIKPALITLAIFTFMGAWNEFMWPLIATTKDAMRTL
                     TVGLSTLKTFQITNYGQMMAGATITFLPPFIFYLILQSKFVEGVSLSGIKG"
     gene            14105..15853
                     /locus_tag="KRO40_001232"
     CDS             14105..15853
                     /locus_tag="KRO40_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4091 domain-containing protein"
                     /protein_id="HBH2092054.1"
                     /translation="MEISYVLKDCTFKHNKYSVVEAETWKDKDLDIVVAKGEKFAFQI
                     MLKATEEFNCTIDKSSAISWKGLGNRVRLALNMPNSLENNFSINILGYVQDDTKAFVN
                     DAILRDKDVLVEQYLPQTFWIEGQVPEDFEENNLDIGIDIFKSFGYEDEEKVCTIDVP
                     VKVRNVVLKPLDESKFFLDLWQHPSCLARMYKVELWSDIHFEIVDNYLKELASLGEKV
                     ATVIVSDYPWAGQSCYKVYKNPSNLYEYNMVSVSKGLDGKIKCNFESMDRYISIADKY
                     KMAKEIDLFGLLGNWCAGEFGNPVEGYKDPIRVRYFDEKDKVFKFINNTNDLKEYIGL
                     VLNHLIECGLWDRVRIIADEPNNPEVVKECIEFINSTVGTHQVKYKSATHDQNFLDRA
                     KDEIDDMSINLKLTIQNYKDIESLKKKINDKGGILTWFVCCFPEKPNSFLSSPFVENR
                     IIGWYTYYFGLDGFLRWDYNLWTEDPWKDSSYKFPIWKAGDMFFVYPGKDLKPVRSVR
                     MENLRFGIQDFELFTMLEKEKGREYIEVELMQELLNKKENAEIKGFGDIELGYSLDNW
                     GYDKVKKYVLELLDRV"
     gene            16115..17137
                     /locus_tag="KRO40_001233"
     CDS             16115..17137
                     /locus_tag="KRO40_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 5 protein"
                     /protein_id="HBH2092055.1"
                     /translation="MFGGINIKRIGIIIMFFLSISFIGFYLVIRDNSDTVKMQRGINI
                     GNALESPKDFPWDVKMSNKFFDDIKDAGFDTVRIPVRFSDYTSDSDNFKIDEEFFKKI
                     DKYVDYALDKDLIVVLDLHHFEEIMKEPRVHKEKFLKIWQQIANRYQKYDKKLVFELL
                     NEPKENLYSQLLNEYIEEAIKIIRKTNPKRTIIVGPYNFYQIDYLNELNIPKDSNIVV
                     SFHYYEPNDFAFQGNIYHKGFEHLSNITWEGTNEQMDYLKKRFDTVENWANKNKVKIF
                     LGEFGITKEAPEASRRAWIKAVREEAEKRNFSWAYWELASGFGIYNQIEGTWDRDILS
                     ALIEKR"
     gene            17142..19448
                     /locus_tag="KRO40_001234"
     CDS             17142..19448
                     /locus_tag="KRO40_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH2092056.1"
                     /translation="MKKNSKKILITLTIITNVIYILWRIFYTVPKEEGKFALICAIIL
                     LFVEIMGMMEMFVHYYGMSNIEYPEKPIISEELYPHVDVFIATYNESVDLVRKTVNGC
                     IHMQYPDKKKVHIYICDDGNREEMCILAEKMGVNYITRTEREGAKAGNLNNAMQHTNS
                     PLIATFDADMIPMHDFLIATVPYFLKNEQAKKDGEKEEYEKVGFVQTPQSFYNPDLFQ
                     FNLHSEGRIPNEQDYFYRDIQLARNRTNSVIYGGSNTVISREALEEVDGFYTYSITED
                     FATGILIQSKGYRCYAIPEVHASGLSPTDLKSLIKQRERWARGCIQTGRRLNILFRRG
                     LGFWQKISYISSITYWYASIKRFVYIMAPILFSVFNVIVVKCTLLQVLVFWLPMYILS
                     SLSLKIFSQNIRNTRWTNIYETIMFQSLMPAVILETFAISKNKFSVTNKSKLEENRMY
                     KFLQGIPYFIYMVLSIIGILKMFVAIFKMSSMTYSVVLFWLIGNLFNLVMATLFISGR
                     QQLRKSERYIAEIDFKLKQNSYVLSSKTIDISENGFAFLLENPEYISPEEEFEVEFRE
                     KSGNEMYIANMKAKIVNVVEVNSKWKYAAYITHIEDSEIDNWMCIVHDRIPTLPMTIS
                     NQLGFFDDLQINVKKRIEKTRTLSRRSPRINMNFQMDIKNTGKLRIVNFNYQYVLLNF
                     ENKSIYPKEIALEINENIVLECDLCEGKIDERGILYKVNNIDSIMQNFFLRDEMMDWI
                     LQNKKILDSKPSEKKEKSIDEFEPMEYI"
     gene            19420..20535
                     /locus_tag="KRO40_001235"
     CDS             19420..20535
                     /locus_tag="KRO40_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092057.1"
                     /translation="MSLNPWNIFRRDEMKTLKVFFCSTKYLILVFIFFINTTFISSAT
                     SDKILDLSFKKIETDLSSKITYEDTGVKIETDSSKSDKERYLYIYQNIKENWSMYNNF
                     YIEIQNKNKSSQRINLSIQSKNMLEFRLKEGSEVFLEGKNIIYSDKIKEGCIEVPGEF
                     EGKIYVNFNSLINEESNVVLDSNMLSNIVSWGITFIPSDEEHNIVIIKKISLLSEEKL
                     RFLNNIKIIGDEEVQIPVLGQSISQYEVLGLKSDSKIKYSLMGKQDNVSISQKGKLTL
                     SNKAKPGQIILQVNVDDKFKIGKKITLTESWSVNKKDKDGVPYTLVYPEQSPTVQDMK
                     KINFMNNIITFVRILFVSLVIICFGIYLYWKKCSKTK"
     gene            20553..21971
                     /locus_tag="KRO40_001236"
     CDS             20553..21971
                     /locus_tag="KRO40_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBOAT family protein"
                     /protein_id="HBH2092058.1"
                     /translation="MLFSSLIFLFYFLPITLVLYYVFRFNRTIQNMILLAVSLFFYAW
                     GEPKFVVIMIVSIIMNYIFGLLVDRYRESKIKVKVFLVLMCAYNIGVLFIFKYLAFAL
                     RNISELISTELTIPSIVLPIGISFFTFQGMSYVIDVYRRHGEVQKNPFYVGLYIAFFP
                     QLIAGPIVRYESVAEQILNRKETWNKFSIGTCRFITGLGKKVLISNNMAIVADYIYTM
                     NSQGEIAASLAWLGSIAYTLQIFFDFSAYSDMAIGLGLMFGFKFEENFNYPYISKSIS
                     EFWRRWHISLGMWFKSYIYFPLGGSRVANKDIMIRNMFIVWLFTGIWHGAEWTFVIWG
                     ILNFVFLIIERFIMFEKIENHNFIKHIYALLVVNFGWVLFRSPNLKEAYNYFKAMFGG
                     NGAIWSDYTYMFLKEYWVFFIFAFIFSVPIAKKINKFVVEQAKYSMIFNVFYPISAIL
                     LFFISVTYLVTGSYNPFIYFNF"
     gene            21986..23194
                     /locus_tag="KRO40_001237"
     CDS             21986..23194
                     /locus_tag="KRO40_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092059.1"
                     /translation="MNRFFKVRLITAIMFLIILFAFSIFNVCYSGKDTIQEIKNSIAE
                     KSSLKDTISSIDNTVNDKVIYKNTFIETYGYLQKLMGKNEFSKFSVVKDTSGKMHYTY
                     FAKAPNPVGVIADRVRKFSDEMEKQNTKLVYLMTPDKYIKGVTKFPKGIPYSYSNETA
                     DNFLNQLKKYNVDYIDFRENILKSGIPKDDLFFKTDHHWKVETSFWAFGELVEQLNKK
                     YNMNLDENHYYRDKDNYNSIVYPKSFLGSMGRKTGILYGGIDDFTLIYPKFKTNYTYY
                     TDSKSQKFELKGRFEESLILSYPFNADLDLMDGQSDKYFTYLLGNRPLVKIKNIENPD
                     GLKVLFVKDSLIVPTAAFFSSVCSSIDMIDPRYYDGDILEYAKSHDYDFVFISVYPQN
                     LTKEFFPFCE"
     gene            complement(23268..24656)
                     /locus_tag="KRO40_001238"
     CDS             complement(23268..24656)
                     /locus_tag="KRO40_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="HBH2092060.1"
                     /translation="MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLR
                     TIYATVLGLILGIIIQAFAGFPNDTTQVIWLQEVSKWYSLFGSGFMDLLKMLVVPLVF
                     LSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
                     QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPF
                     IGFIEASYKIIVSVSMTVIKFMPYAVVALLANTITSQGISSIVSVLQFILALYISVAI
                     LFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTIESLVQNHGVDEGVS
                     SFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLP
                     GTATMAVSVVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGK
                     IDKEVFSKKNIS"
     gene            24997..26331
                     /locus_tag="KRO40_001239"
     CDS             24997..26331
                     /locus_tag="KRO40_001239"
                     /EC_number="1.8.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-disulfide reductase"
                     /protein_id="HBH2092061.1"
                     /translation="MRVIIIGGVAAGMSAAAKLKRIKPEYEVVVYEKTEIVSFGACGL
                     PYFVGGFFNDADELLARTPEKLREAGIDLNIFREVVEVDSESKKIKVKNIKTDEIYED
                     YYDKLMIATGARSIMPPIKNIKLKNVSTLKSLYDGEYLKKLLSNEDNKRVTIIGAGFI
                     GLEAVEACKKLGKDVDVIQLEDRILPQVFDKEMTDVLEEEINRHNVNLHLDEMVVELC
                     GEDKVEKVITNKGEIDTDVVIIATGVRPNTEFLSNTNIKMLKNGAIVVDEYGRTSVED
                     IYSAGDCATIKNIVSNENVYVPLATGANKLGRIVGENLAGREISYQGSLSSSCIKIMD
                     MEAASTGITERQAKDLGINVKSKFISDYNQTHYYPGRNKIYVKLIYDADTKVILGGQV
                     AGFKDAVQRANVLAAAIFGKMTTNQLGMLDLCYAPPFARTWDVLNVAGNVSK"
     gene            complement(26473..27390)
                     /locus_tag="KRO40_001240"
     CDS             complement(26473..27390)
                     /locus_tag="KRO40_001240"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011969064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HBH2092062.1"
                     /translation="MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSM
                     KLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNSGRTSDLTIVGPVGIVDCIRSMR
                     NLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
                     DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPD
                     FIKDSDLFICEAMYGDDLDISKAVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIP
                     SMYLENATNVFENTILGEDRLSLRLNFDE"
     gene            27598..28482
                     /locus_tag="KRO40_001241"
     CDS             27598..28482
                     /locus_tag="KRO40_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4846 domain-containing protein"
                     /protein_id="HBH2092063.1"
                     /translation="MKVLKKITILSLITLTLVGCSNGEDKKVVEGSKKIQNSKKDEQP
                     IIVHKDANILKDRYEPPKGFKRVDVEKGSFESFLRNTKLKNYGEKVKYYDGRTKESKG
                     IYDSVFDVDIGNRDLHQCADAIMLMRAEYLYQNKLYDEISFDFVDGFKAKYSKWAQGY
                     RISVKDSGSSWYKATEYSTSYESFRKFMDIVFAYSGTLSLEKELEPVKVEDMKIGDVF
                     IVGGSPGHASIIMDMAENEKTGEKVFMIAQSYMPAQQTQLLINRKNPNLSPWYSLDFE
                     GDLTIPQWTFKRDQLKRF"
     gene            28695..30536
                     /locus_tag="KRO40_001242"
     CDS             28695..30536
                     /locus_tag="KRO40_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="HBH2092064.1"
                     /translation="MKIRRYLILVIIILITTSQSFISYGLERFEEITIFHTNDIHGRY
                     AEGDDHIQIGNLATLKKETPNSILVDAGDCLHGLPIVNMDRGKSAIELIKCAGYDYIT
                     PGNHDFNYGKDRLFELSKSANLGENTLKFLSSNIFENGKKVFDSNDIKEIDGIKIGFF
                     GLSTQETKSKTGFKNVEGLEFKNPIESATEQVNELKGKGANVIVAICHIGTNSLSKPN
                     SIDIANEVQGIDLIIDGHSHTKFENGKQVGDTLIVSAGQYLENIGEIKLTLDTNDVEN
                     IKIENKSVRLIGKEEALKYKLDSAVSKKVDEIKEQQEKILDKVIGVTTNTLDGSYENV
                     RTKETNLGNLISDILLDKTKADISLFNGGNIRDTIEKGNITRRDIVDVFPFNNTIVTK
                     ELTGAQIKDVLEHGVKLYPEKSSAFLQVGGISYYFNPKQKEGEKITNIQKEGKPLDLN
                     KKYVVATNDYIASGGDEFPCFSKEPVLKEFGNLESAVIEYIEYKTEISKNVDGRIGIK
                     SKDELISKNHESDLILSENEKNINDNEENLSNNIKSSDSDKNKSLDKTSARESSNLGI
                     SKREAKEKSPKTGDLGFSNSIIIFIVSSTLICLLNFNQKELKDKKSK"
     gene            30841..31548
                     /locus_tag="KRO40_001243"
     CDS             30841..31548
                     /locus_tag="KRO40_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092065.1"
                     /translation="MNNILLLEDDKSLNRGISFKLKKEGYNVFSAFGIEEAKNIFAKE
                     EICLIISDIGLPDGSGFDFCEEIRKKSDVYIIMLTALDEEVDIVTGYDLGADDYITKP
                     FSLMVLISKVNALMKRVNTVKNYTLLVCDDLFFYYIENKLIIRTDDKEEEIILSKTET
                     KLLKYLMENSMQTLTKEQLLESLWDSSGNFVDDNTIAVNIRRLRQKVEKNPSEPKYIK
                     TVRGVGYMWGERSIKKC"
     gene            31542..32852
                     /locus_tag="KRO40_001244"
     CDS             31542..32852
                     /locus_tag="KRO40_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092066.1"
                     /translation="MLKNMNLKDGLSVKDDYIMRRVIVYSVLSVLIVTLVFILFEYSR
                     LHKLYEHQIKNTQNIAGILIEKYPNDEIDIVNSIYNSDYSKVSTGEKAFKKFGYGLEN
                     KMSNDKNFSLYLKSFFKESFFIFLMMFIVVIGIIYYFIRYINKRLSKIYFIVDKMSQE
                     NYLKDTTESEETGYLVEYNEYFKEGIFSKINNCLYELNRSLKIKFIKLEKEKESVKSL
                     VTDISHQLKTPLASLKLYNTLLIEEELEEDEANEFLLTNKASINKLENLINSLVNISR
                     LEISMINIKKEDNDIKNTILNAVKSVTPKAKSKSITLNLNEFNSRIIPHDKKWTEESI
                     FNVLDNAVKYTQVNGEINISVEETANFFKIIIEDNGIGIEKNEFNNIFKRFYRGSADE
                     IESVEGSGVGLYLSRKILEEQGGNIIVSSKVGIGSKFSLFLTTM"
     gene            32969..33652
                     /locus_tag="KRO40_001245"
     CDS             32969..33652
                     /locus_tag="KRO40_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092067.1"
                     /translation="MKILYTENLSKHYGKGESLVRALDNVDLEINEGEFVAIIGKSGS
                     GKSTLLHMIGGLDIPTSGKVYIDNKNIFTLKEEELAVFRRRKIGFIFQSYNLIPSLNV
                     WENVVLPIGLDGREVDESFIKELLKSLGLENKHDVLPNTLSGGQQQRVAIARALATRP
                     AIILADEPTGNLDSKTSDEVMSILKSMSKKYSQTLVMITHDDSIAQMADRVIFIEDGR
                     VSKVGDKND"
     gene            33645..36032
                     /locus_tag="KRO40_001246"
     CDS             33645..36032
                     /locus_tag="KRO40_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2092068.1"
                     /translation="MINTTKIAKSNLKQNKSKSILIIITIILSTLMLSSIGIYIVDAG
                     AYQKENTIKYSGNYQGILANVDEKQADILSNHADVELTGEMNGVGVEKLEDDSNISLA
                     YMNEDALKLNSFEFIKGKLPSKENEIVLDSGALKALGYKNKDLGEKIKISYDDYKSDK
                     KIEKEFIISGILKTSEISEAGKYYYAIISESYMRNTRDMSQEDFNIYVKLNDKSNLSI
                     EQAKSKLNKIANDVGLDTINVAVNENYINALKPDMETIMGGVFVGLVIVLSSILVIYN
                     IFYISIVTKVQEFGKLRAIGATKKQVKNIVFKEGFILAGIAIPIGIILGYVLANIIIK
                     SFMDIDVKSSRLPVILSVVVISFISVVLSLLKPMKVASKVSIVDAVRYTGNKISNKSK
                     RKGYKNINLKRLSHANLERNKKRTYMTLASLILSGTIFITVSTALESFDAEKMAREHF
                     PYDIEVRLSGYEMNSDKNPKDNLNILQMDNPLSKDFFNQIKNMEGIKRIESARSVKIG
                     MEDYDVEFKYDLLQSINENDVKSLNKNIIDGKINLERLQTGDEIVITHVDTAKEMGVK
                     AGDKIRLTLYDGDKKIKKEFKVQAIAMGVPSFGIGKDFIDRTLKYDSTSSLGIYTEEG
                     KYQEIKDSIKKIAKNNGFLETDFIDSRIESNKATISFIKIMGYTLTGIIGVIGFMNLV
                     NTMITSIVTRKKELGMLQAIGLTNKQLVKMLNSEAMYYTSGMMIGSILFGGILGYIAV
                     IFLKKTGLSYATYSLPIVPILLMIVCILIAQFITTYLIGRSFNKESLIDRVRYSE"
     gene            36312..37454
                     /locus_tag="KRO40_001247"
     CDS             36312..37454
                     /locus_tag="KRO40_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH2092069.1"
                     /translation="MNKKINYAPGPTETRENVRLARAEKTTNPDIDIDFVEFYKKTCE
                     KFGNIIGTKNDVYILSGEGILGLEAACASLTEKGDRVLVIDNGIYGEGFKDFVTMYGG
                     EYVLFSSEYTKSIDIDELKAFLDEDSNFKYATVVHCDTPTGVLNDVSKICPLLKEYGI
                     LTVVDSVAGMVGERLSVDESKIDIILGGSQKAISAPAGLTIVGISQDAKNCIKNRKTD
                     VIGFYCNLNIWEGYYEKKYFPYTMPISDIMGLDKALDNILEEGIENVLNRHEKIAYSV
                     RKSIEEYGLELFLEEGYSNTVTAIKIPESIGALELTDYMLKNYNTLVATSLNQYMDTI
                     LRIGHMGENANLNKIEHVLNVLDKSLSALGFKGNGNLLNLFNKYYF"
     gene            37473..37997
                     /locus_tag="KRO40_001248"
     CDS             37473..37997
                     /locus_tag="KRO40_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH2092070.1"
                     /translation="MEVTAKQKFTTKDMVETSLLIALVFIATKFINIRLPISINGGLV
                     HLGTAMLFISAIVFGSKKGALSGAIGMSLFDLISGWTLWAPFTFIDRGVMGYLLGKIA
                     WANGNNGNNFLINVIGICVSSIWMLFGYYVTEVILYGNFIVPLTSIPGNLMQVLIGLI
                     IALPISKVLKKCIK"
     gene            38097..38915
                     /locus_tag="KRO40_001249"
     CDS             38097..38915
                     /locus_tag="KRO40_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2092071.1"
                     /translation="MLSVTRYSIKNVRLKPWVKFIWYFETKSNILLNNKLLPTDSIDI
                     ILNLSDVMEYKIENQDYIASNIHFNGIRDKHGFIIQHGNIRVIGISFYPFGLYPFLKI
                     PISEFNRQIVDLEAVSKLFAKKLEESLNPTKAIEKVVLCLEEVLLSILEEDLISNKYV
                     KLLNSFIYVNRYSNIKAFCDDTNINIKTLERICLKYTGYTPKILKRIYRFKMASNQLI
                     YNYKDDELFDFIYENEYYDQAHFIKEFKKFSGTSPIKFSGENKTIKENIKYSYL"
     gene            38993..39304
                     /locus_tag="KRO40_001250"
     CDS             38993..39304
                     /locus_tag="KRO40_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="HBH2092072.1"
                     /translation="MKIITEIVEFNVEENLSKEEFIEIVNDLELKFHSIQSGFIDTEL
                     LYDEKSQKWIMIQHWESIEDLKSVSSKMFKDSSTEKFRKALKNQTVKMNIIPQIKSWK
                     L"
     gene            complement(39481..40164)
                     /locus_tag="KRO40_001251"
     CDS             complement(39481..40164)
                     /locus_tag="KRO40_001251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092073.1"
                     /translation="MQKEVAMNKLIKDCVNFFNDCGFSYSICGGYALELFANMHIRPH
                     SDIDIWISDTDKEKSIQYMLNQGWDIYEPLGNYLLRPIIDLNKQHIEQICVFAIKPDC
                     SFIELKKVEDDNYKMNIQCDEQLQFDFIELIYNPQKDGKFLFSQNQRIIRDMDKARLI
                     TSDNIPYMAPEVVLFCKSIYIDRLGYQKDFDVTVPLLSQEQRDWLVNALITAYPDGHA
                     WIDQLANQY"
     gene            complement(40257..40898)
                     /locus_tag="KRO40_001252"
     CDS             complement(40257..40898)
                     /locus_tag="KRO40_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2092074.1"
                     /translation="MGRKKEPDNTIQKILDISHKLFLEKGYEQTTIQDIVDNLDGLSR
                     GAIYHHFKSKDEIIKAITSRLYNDGFYGYEVKNDEGKTALEKLQYRLLHAYEQHNKQD
                     IFLMSSSLLRNPKYLATQFDEIINDIVPWIKALIEEGNQDNSMEVKNPEIAAQMFGFL
                     LNTWCIPTVYPGNPQQMIERFTLFGEQAAFMGISFMNDKIMCEYQKFVNKFSK"
     gene            complement(41072..43075)
                     /locus_tag="KRO40_001253"
     CDS             complement(41072..43075)
                     /locus_tag="KRO40_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase C-terminal domain-containing
                     protein"
                     /protein_id="HBH2092075.1"
                     /translation="MKSQKRFKILDIDVYLQPFESDIKKRMKHYEDMKSKTLKNYKDF
                     SSFANAHLYYGFHQTNDGFFYREWAPNADSLSLIGDFNNWNRKSHPLRKIGSGNWEIF
                     IPGQNSLPHKSEVKVQVTANGKTFDRIPLYIKRVIQKDFGGFNGQIWQPKTPFIWTDN
                     DFDLKNITSPLIYECHIGMSTESESIGTYNEFTEKILPKIKKAGYNTIQLMAIMEHPY
                     YASFGYQVSNFYAISSRFGTPEDLKNLINTAHSMGIAVLLDLVHSHAVKNTLEGINEF
                     DGSEHQFFHSGSKGNHPAWGTKLFNYGKPEVIHFLLSNIKFWLNEYHFDGFRFDGVTS
                     MLYHNHGLGVSFDSYEKYFSMNTDIEAITYLQFANELMKEIKPNSISIAEDMSGMPGM
                     CIPIKDGGIGFDYRLAMGVPDFWIKTISNLSDEDWDLGKMWYELTTRRPGEKNIGYCE
                     SHDQALVGDKTIIFWLADKEMYWNMEINSNNHVINRAISLIKLIKLITFSLAGEGYLN
                     FMGNEFGHPEWIDFPREGNNWSYKYARRQWSLSEDNNLKYKQLLNFDKSMLELTKYSD
                     IFIQNSHELIHMDNDKKILVYSKGKYLFIFNFHPNLIQSVDISKFQNTNYKTILNTDM
                     VEFGGNTKKENLRDYDVYFSSTPPSSKMPIASRTAIVLLDNGI"
BASE COUNT        16847 a         4695 c         7490 g        14100 t
ORIGIN      
        1 ataattttat ataataaata agtaaaaata gtaaaaaata aattaagaaa tgtttttaat
       61 aaaaataagc ttaagggggt caaccatgag tgcaaaggta acgaatcaat atggaaatat
      121 agaaatagat aatcaagtaa tagctcaagt cgtatataga gctgcaatgg aaagttatgg
      181 cttagtaggt ttagcatata agtctaaagg aatagtagag ctattaaaag gcgagaacgc
      241 aactaaaggt gtaagagttg aggaagtaga agaagatgcc atagcaatcg aactttatgt
      301 tataatacaa tatggtacaa atatatctac tgttgccaat aatataatag atagagtaaa
      361 atatgtagtt gaaaaaatga ctggcgtaag agttactaga attgatatta atgtacaagg
      421 aataagagtt aagtaatttc ataggaggaa acaaatgatt caatatatag atggtaaaag
      481 gttaagggag atgtttattt caggtgcaaa caatctccaa aacaataaag agttagttga
      541 caagttaaat gtattccctg taccagatgg agatacagga actaatatgt cattaacaat
      601 atcttatgcc ttaaaagaat tagcaaaagt tgaaaatgat aatatatcag atatcggaaa
      661 agcattatct aaaggttctt taatgggagc tagaggaaac tcaggagtta tactttcaca
      721 aataatcaga ggtatagcta aatctataga aggaaaaagt aaattatcaa cagaagattt
      781 agcaaaagct tttaaaaatg gttcagacac agcatataaa gctgtaataa aaccaattga
      841 aggaactata cttactgtag ttagagaaag tggagagttt gcaataaaaa ctgcgaaaaa
      901 agagaaagat gtagtaaagt ttttaagtat gcttgtgaag gaatcaaatt cttcattaga
      961 aagaactcca gaccttctaa agaatctaaa agaagctggt gtggttgact ctggtggaaa
     1021 gggtcttgta cttatatatg aaggaatgtt agcttctata aaaggcgata acatagaaat
     1081 aaaaaatgtt gacctagata ctaatatttc aacaagtatg gattttgcaa agagtactac
     1141 tagcacagat gatataaaat attgctattg tacagaattt attttagaaa gttctaaggt
     1201 agaagatact aaaataagag acataatgat ggcttatggt gatagcctag cagtagttgg
     1261 agatgatgga gtcataaagg tacatgtaca cactaatgac ccaggaaatg tacttcaaga
     1321 agctctaaag tacggtcaat tattaactat aaaaatagaa aatatgaagt tacaacatga
     1381 aaatacatta ctggatgtag aagaaaagaa agaaaatgat agtgaacctt tagaagaaga
     1441 aaaagagttt gggtttatag ctacttctat gggtgaaggt ttggcaaata tatttaaaga
     1501 tttcggagtt gaccatataa tagaaggtgg tcaaactatg aatccaagta ctgaagattt
     1561 tatgaatgct ataaagcata taaatgctaa aaatatattt attttcccaa ataacagcaa
     1621 tataataatg gctgctaatc aggcaaaaga attgagtgat aaaaatataa tagttatacc
     1681 tacaaaaaat acgcctcaag gatttgctgc attagtaact tttaatggag aattaagcga
     1741 agatgaaaat aaagaagcta tgatgaatgc tttaaactca gttaaatcag gtcaagtaac
     1801 ttttgctgtt agggatacag tgatgaatga aattgatgtt aaagaaggta atataattgg
     1861 aattgcagaa ggaaatttat tatcagcagg agattatgtg gatgaagtaa catcaaacct
     1921 tattgaaaag ttggttgatg aagatactgc tataataaca ttattctttg gtgaagatgt
     1981 tacagaatct caagcaaatg aactacgtac ttctttagaa gaaaagtttg aagatgtaga
     2041 tgtagagtta tattatggag gacaacctct ttattattac ttaatttcag ttgaataatg
     2101 attataagaa cctgtatgac caagtagctt ttataaaatt ggttgtacag gatttttgtg
     2161 tagtaggtga tatatttgtt ggatttatat aaagatgttc aatatgttaa gggaatagga
     2221 cctaaaaaag cagataaatt aaataaactg ggtatattta cactaaaaga cctattgtat
     2281 tattttccaa gacaatttga agatagaaat aatctaaaga aaatagcaca attagaagat
     2341 ggtgagaaag ttacgataaa agcagtaata tcaagtataa atacatttag cccaaaagaa
     2401 ggtatgactt taacaaagat tgatgtaaaa gatgagacag gctcggctaa attagtgttt
     2461 tttaataaga gttatataaa aaatactttt cgtccaggag attcaatatt agtttttggg
     2521 aaggttaaga aaaaatttaa taacttagaa cttacatcat gtgaattaga atatcttact
     2581 aattcaccta agaatacatg tagatttatg cctgtgtacc agcttacata cggtgttaca
     2641 aataaagaaa ttatgagtat aattagaaca gtacttgaag ataaagaatt aattatacaa
     2701 gaatatatgc cacaaagaat tatagaaaaa tataggctat gtagtataga ttttgcagtt
     2761 agaaacatac attcaccaag tagtaaggaa tcattaaaaa tagctttata tagaattgta
     2821 tttgaagaat tacttatact acaactaggg ttgtttgtat ttaaaagtgg cagaaataaa
     2881 gaagatggaa taaagtttga aacaagtaaa gacttaaaaa aaataataag tgctttacca
     2941 tttaaactga ctaaagctca aaacagggca ttagatgaaa ttatacaaga tatgaattta
     3001 gagaaaataa tgaatagatt ggtacaaggt gatgtaggga gtggtaaaac agtagtagct
     3061 ctcttagcac ttgcaaattg tgttttaaat ggttatcagg gcgctttgat ggcacctaca
     3121 gagatattag cagggcaaca ttatatttca cttactgagt ctctaaaaga ttttggaata
     3181 aatgtaggtc tattaatagg tagtcttaca aaaaaacaaa aggatacagt attggaacaa
     3241 ataaagaata atgagattga tatattaata ggtacacatg cactaattga agataaggtt
     3301 gaatttaata atattggttt agttataaca gatgaacaac atagatttgg tgttatgcaa
     3361 aggagcaaac tttcattgaa aggagcaaat cctgatatat tagtaatgac agcaacacca
     3421 ataccaagaa ctttagcact tatactctat ggagatttag atatttctat tatagatgaa
     3481 cttcctccag gaagacagcc aatagaaaca attgctattg aaaaaagtaa gcgagataga
     3541 gcatataata atcttgtaag aagagaggtt gaatcaggaa gacaagtgta cattgtatgt
     3601 cccttggtag aagaaagtga agccatagaa gccaaatcag cagttgaact tgttgaggag
     3661 ttaagagcgg aatattttca cgacttaagg cttgggttgc ttcatggtaa aatgaagtca
     3721 agtgaaaaag atgaagtaat gagacttttt aaagataaag aaatagatat tttagtttca
     3781 acaacagtaa tagaagttgg tgtcaatgtg ccaaatgcaa cattaatgat aatagaaaat
     3841 gcagaaagat ttggacttgc acaattacat cagcttagag ggcgagttgg aagaggtagt
     3901 cataaatcgt attgtgtact aatttatgat tctaaaacag atgtatgtag acaaagaatg
     3961 gctataatgg aagagaccaa tgatggtttt aagatttcag agaaggattt agaaataaga
     4021 ggacctgggg aattttttgg gacaaggcag catggtcttc cagaacttaa ggtagcaaac
     4081 ttatttaagc atataaaaat actgaagtta gcacagcaag aagctcgata tatattgggt
     4141 gaagataata atctacaatt aaaagaaaac atggcactca aaaaagaaat tatagataaa
     4201 tttaaagata cattgaaaga aatttcatta aattaatttt aaattgtgtt aaaatattac
     4261 taatgtaata atgtgctgaa gggagattgt catattgaga gtaatttcag gaaaagcgag
     4321 aggattaaaa ctaaatactc caaaaaatga agatgtaagg ccaactacag atagagtaaa
     4381 agagtctcta tttaatatga taaattcata tataatggaa agtgaagttc tggatttatt
     4441 tgctgggact ggttctttag gaatagagtg cttatctagg ggtgccaagt catgtacttt
     4501 tgtagatatt agtaaggaaa gcatagatat tgttaagtcc aatataaaaa aggcaagagt
     4561 tgaaagtgaa agtattattt taaaccttga ttttaagact gcaatagata aacttaaatt
     4621 acaaaatagt aaatttgaca taatttttat ggaccctccg tattataaaa atatgtttat
     4681 agaagctatt gaaaaaattg ataattctaa tctattgaac gaagatggaa taatagttgt
     4741 agaacatgat acgaatgatt tatttccaga taagatatgt aaattggaga aaactagaga
     4801 taagaaatat ggaaatacta cattaacttt ttataagatg gaggcataat atggaaaata
     4861 aacctagaaa agctatattt gcaggaagtt ttgacccaat tactaatgga catttagata
     4921 ttatttgcag ggcttcgaag ttatttgacg aattacaaat aggagtatta aataatccta
     4981 ataaaaaggg tctatttagc tttgatgaaa gagtaaaact tatagaaaaa agtacaagcc
     5041 atttaaataa tataaaagtt gtgacttttg atggtttatt aataaattac tgtcaggaaa
     5101 atgggattgg agcattagtt agaggtgtga gaagtggtgc tgatgttgat tatgaacttc
     5161 agatggcaca tatgaataga gagcttaatc cagatataga gactataatt ttaccaagtt
     5221 gtacaaaata ttcatttata agttcatctt taataaaaga ggttttgctc tttgatgctg
     5281 atataaaaaa tttggttcca aagattgttt tggaagaatt aaagaaaaaa actagtgggg
     5341 gtaattgata tatgaagata gatttagaaa tgattgaact atttgagcag ttagaggaga
     5401 tatttagaag tgcttctaca atccctttct cacataaatg cacagtggat aaagatgagg
     5461 ttttagcaat aattaatgat ataagaactt taataccaga agaagtaaca caggcagtat
     5521 ggattaataa agaaagaaat aaaataataa gtcaagctaa gcaagatgct acaaatatag
     5581 ttgaacaagc gaaaaaagaa gctgagagaa tacaacaaga atatcaagat aatatagagg
     5641 aattaaagaa aaattctgaa gatgtagtaa aggcatatgt agaatccagt gaacctgttg
     5701 ttcaagcaga ccaaagagca aaagatatag ttgatagagc tgagagaata gccaatgaga
     5761 taagaattgg gtcaattgaa tatgcagagg atgtgctttc tagtgttgag tataatttaa
     5821 gagaaatatt agaagaagta aaaagagata aagctgaact tagacctaaa aaataaattt
     5881 taaataaata aaaatggagc tatcacacaa aaaattccaa tttatgtgtg atagctctct
     5941 tttaatatag caattttttg ttatataatt gtgcttttta gattacttat atcttatttt
     6001 gatattataa tgtagtttaa tcttttattt gttgaaatca acttatttat ttgtataaat
     6061 aatataggtt attttcaaat ttttttaata attttaccac tgtcttcttt tagattagag
     6121 ttagactgtg caaaattata aaataatact aaatcatgtg caattatttg gtatggcact
     6181 acatgtagaa aatatagata ataaaattaa ggaggtagta tgaaggaaag ggctaaaaaa
     6241 atattagatt ttattattaa aaataacaat gtaacatcac aagaactaca agaaaagttt
     6301 aatgtttcaa agagaactat ttattacgat attctagcta taaatgaaca actaggaaaa
     6361 agtggtaata taaaaaatgt aaaacacaaa tttatatttg aaggtaattt atgtgatgca
     6421 aggaaaataa tttcaactga agaagataaa tttttagata gtgattacag aaaaactttt
     6481 atattaaaca agatattact tggcgaaaaa atatcaatag aaaaactaac aaatgaaatg
     6541 ttactttcaa aaaacacagt agtacaaaca ataactgatg taaaaaaata ccttcaaaca
     6601 atggggttaa gattagagta taagggaaag tacaaaatta taggtgatga atacgttatt
     6661 agagagctgt ttctgataat tgttcaagaa aatatattgg aaattaattc tataagtgag
     6721 gaagtaagta gtttcgatac aaaaggacat ataaaactta ctgattattc tttattaaat
     6781 ctaactaagt ttgtggaatt tctaaataaa aggataagag atgggaaaac attatactca
     6841 tataaatatc taaatgaagc taaaaaaatt agttacttta gtaattgtaa agaactttta
     6901 tgtgaagaag ctaatgaaaa tgaacaagcc tatatatgca cttacataag ttcacttccc
     6961 agcttaaata gtgaagttaa ggaagatgtt gttgaagaat atgtagataa acttatagat
     7021 aagtttgaag taaatacagc aataaaatta gaaagtaagc atgagtttaa gaaaaatatt
     7081 ttaaggcacc tccattcttc ttacaacaga atacgattta agtttcctat tagaaatcca
     7141 atgttagatg agactaagta taaacatgag tcactttata aaattataaa atcaattata
     7201 gaaaatgaag aagagtttcc tgtatttgag gggataagag aagaagaaat aggatttata
     7261 gcagcgtatt ttggaggata tttaagaggg tctagggata atggtctaag aagaaataaa
     7321 gtcttactag tttgtcctaa tggtcttatg gtatcaaaga gtttggaaat acaactatat
     7381 aaatacatac caaccataga aatagtaggt atagtatcca ttaagcaact aaaagaagta
     7441 aatgtatact acgattacat aattacaact atagatatac aaaatgtaaa caacgtaatt
     7501 gttgtaaatc ctcttttaac atcatcagat gttcaattac ttatgaacaa actaataagt
     7561 gtaaaagaaa acgagaagta tttcaatctt gaattaataa tacaagctat aagaaaaaat
     7621 ggagttatca ataatgaaga agcactaaaa gctgatttat taaacataat acacaagata
     7681 gatgaaggag agatgtatca accaatgtta aaggaattaa ttaatgcaga aagggtcaat
     7741 ataataaaaa gtgttagaga ttggaaagaa gcaataaaaa tagcctcaaa gccattgtta
     7801 gaagataact ctatagaaga gttatatata gaaaatatga taaagtcagt tgagaaatat
     7861 ggaccatata ttgttttagc tgatagattt gctctaccac atgcaagttc taaagaagga
     7921 gtaaacaagc ttgctatgtc tttactaata gtagaagatg aagttgattt attaggaaaa
     7981 ccagtaaata tatttatggt attagctgct gtagataaca ctactcacat tagagcatta
     8041 gcatcactat cagagatgat gtacgaggaa gaaaatgtaa aactaataat taatggtgat
     8101 aaaagttcaa tactagaact tataaataag caaaattagg aggaatgaaa aatgaagata
     8161 ttagcagtat gtggttttgg tgtaggttca tcaatggtat taaaaatgac aatacaaaag
     8221 gctctaaagc agttaggtat agaatgtgaa gtagaaaata cagatataaa ttcagctaga
     8281 ggtgctgatt gtgactgtat attcacaagt caagaattgt taaatgaatt aaaaggaact
     8341 tgtaatgtag atgtatatcc agttaaaaag tacatggatt tagcagaagt cacagaagtt
     8401 gttcaaactt ttttaagtga taaaaatgat aagaaatagt ataagtttta aaaagtaaat
     8461 ttaagttaat cagaataaaa taaaaactta ctaaattcaa aaatagtaag aaagagagga
     8521 gggatttagt ggtagaaaac ttaaacagtt gacctatcac taaaaaatat aatgcttgat
     8581 tttatttcaa ataatatttt acgtaatcca tctatgttaa ttggattaat agcagcattt
     8641 ggtcttgtac tacagaagaa gaaagcatct gatgttataa aggggtcact acttgcagct
     8701 ttcggaatta taattatgga gactggaaca ggtatgttag ttagttcaat agcaccaatt
     8761 aatggagctt tccaaagtat aagtggtggt gcagtaacaa aaggtttaag tgatgttact
     8821 tttactgcaa gttatggtgg aattataggt ttagcaatgt ttgcgggttt agctattcac
     8881 ctaatgatag caagatttac tcctattaag acaatctttt taacaggtca catgctttat
     8941 tggttcccat tcatatttgt agcttcagga gttgaagctg gattaaatgg tggagtatta
     9001 atagcttttg cagcagtatt atcagcactc tattggtcaa taatgccttg gttattaaga
     9061 aaatatgtgt ttgatgttat aggagatgat tcttttacat taggtcatcc atctggttgt
     9121 ttagcactta tatcaggatt tgttgctaaa ttagtaggaa ataaagaaaa atctacagaa
     9181 gatataaaca tacctcaaag tttatcattt tttagagaaa tatctataag tggtggaatg
     9241 gcagtgtttt taatgtttat agttgttggg atagtaatac caggtgcgtt taaagatagt
     9301 aatgagttta ttggaacgta tgcaataaag caaggtcttt cttttggagc aggtcttata
     9361 ataatgcttc atggggtaag aatgctaata aatcaaataa tgccagcatt tcaaggtata
     9421 tctgaaaaag ttgtgccaaa tgcactacct gcttttgact gtccaatatt atttaattat
     9481 aaaccaaatg ctgtattaat gggattctta gttgctatgc taacatctac agctatgatt
     9541 ttaatatgta actactttaa tgtatttaat ttgctactta taccacttgt tataacttca
     9601 ttctttgagt gtggagcagc agcagtaata ggagaatcac aaggtggtat acgtggagct
     9661 ataataggta cagctatagc tgcaatattt atggtagttt tagtaggaat atctgctgta
     9721 atttactcag gaactattca aaattggata ctaatatttg gaggtaatga cctttcatta
     9781 tttggtataa tcagtaggtt tataggttca ctatttggag gaatattata gatatgaaat
     9841 ttaaatacat agatgagata agaagattaa ttgatataat agaaaacgaa gaaaaagtca
     9901 atatggaaaa agcagtacaa atctttgttg aagcaataga aagtaaaaat gctatatttt
     9961 catttggagc ttcacatgca ggaatattaa cagaagaatt attctataga gcaggtggct
    10021 gtgttcttat aaatccagta tttgcaaaat ctctaatgtt agatacagcg cctataactc
    10081 acacaagtaa gatggaaaga ttagaaggat atggtacagc tctagctgat aaaactccaa
    10141 ttaaaaaagg agatgtagtt atagttcatt cagtatctgg tagaaatcca gtaagtatag
    10201 agtttgctat gaaagctaag gaaaataagg caatagtaat atgtataact aatttaagtt
    10261 actcaaaaag tgtatcttca agacattctt caggaaaaaa actttatgaa gtatgcgatt
    10321 tagtgataga taatcatggt caaaagggag atgcctgtgt agagatagat ggattaaacc
    10381 aaaaagttag tccaacttct actgtaatag caactactgt gatgaactct attatagctc
    10441 aagctactca ggaattagtt aataaagggc taaagaatcc tccgattttc tatagtgcaa
    10501 atattgatgg tggagatgag ttaaataaga agatttttga tgaatataaa agtgtaattc
    10561 attatgaata ttaaggttaa aaaaatatgt taatgaactt tgaagtttat caacaaagaa
    10621 tattaataat atataataaa tgctatcatt taaaagctgt aggtaaaaat ctacagcttt
    10681 ttattattgt agattaaaaa gatgcgtaat taaattttaa attggagaaa ataaattgga
    10741 aggtatcaat tataaatatt agaaacgttg tcatagaaaa aaactatatt aaaaaaaagt
    10801 acatagaaaa aactgattag acaataaata catgctttga taatatttta aatggagtga
    10861 aaatgtgtag aattataatg aaaaaagaaa ataaaaatga aaaaagaaaa taaaatggag
    10921 ggaataaaag tgggtatgtt aaaaaaatta tgttcactag ctatggtagc aattatgact
    10981 acaacactta taacagggtg ttcaagtgga aatggaaaag attcaaaaaa ggatggcgaa
    11041 aaagaaaaac tagttctttg gatgccacca gtagaaaata atatgaagga agtttgggac
    11101 cctattttag ataaatttga ggaaaaaaat aactgtgaag tagatttaca gataattcct
    11161 tgggataatt attctgaaaa atttgcaaca gctataagtg ctggcgaagg tccagatgta
    11221 ggatatatgt atgcagaaat gtatccacag tttatagaaa gtggagcagt agaagatttg
    11281 actaattatg caactaaaga ggataaagag caatctattt atataaaaac atctgaaatg
    11341 atgggtggaa tgtatggtat gccattccaa gcagcaaatc caggggtatt atactataac
    11401 aaggatattt tagagaaatt aggagaaaaa cctcctaaaa catgggaaga ttttaaaaga
    11461 atttgtaaaa aagcaacaca agatactgat ggtgatggaa agatagacca atggggatta
    11521 gctcagggat ggggagctaa aacttttggt aacttaaact ggaactggta tccttattta
    11581 tggcaagctg gtggagatat ctttaatgat gatttaaaat cggttaaatt taatgataag
    11641 agtggtttag aagcagctaa tttcttaaaa gaattacaag catatgtgcc tgaagattct
    11701 ttatctaaag atagtaatga aatgatagaa agtgtatttg gaccagggaa agcagcattt
    11761 acaataatgt tatcttctgc tgcaacaagt gtatttgatg aatcattccc ggatttaaat
    11821 tggggatttg taactggact agaagataag aaagcagcaa cttttggagc agtagaccat
    11881 ttatctttaa tgtcatctgc taaaaataaa gaacttgcat acaagttaat acaacatatg
    11941 ttaagtgttg aatcaatgac agaatttcat aaagcaatac caagagcacc aataacaaaa
    12001 ggtgaaccat atcaaggtga tgaaagattc aaagaaatgg tggaaaatga caaaaatgta
    12061 tatagaccat tagtagtagg acctcatgga gttgaaatat atgaatattt atggaaagaa
    12121 cttcaaacta tgatttcagg agataaaact ccaaaacaag cgttagatga tgctgcaaaa
    12181 tattcaaatg atttattagc acaataaaag tttaaagctg taatatgttg taaaggactt
    12241 tacagattaa aattagcatt gtatttataa atacaatgct aatatttata ttggagagga
    12301 taaaatggaa aacttagtta gagagtttga agaaaattca aaaagaaaaa aaacaaaatt
    12361 aaatattaaa ccatatatgt atatattgcc attgggaata attttagtgg cgttttatgt
    12421 gataccaata ataatgtcaa tatactttag ttttacaaag tataatatta ttagtccagc
    12481 tacttttata ggtttagaaa attataaaaa attatttaca gatgaaacat taaaagtatc
    12541 tattataaat actattaaat ttactgttgt tgtagtacct tgccaaacta tattatcatt
    12601 gattttggct gtttggatta caggaaaagg aaatagtaaa atagcttcat ttgctaaagg
    12661 tgctatattt ataccagtat tatcatctat ggttttgata ggtatggtat ggagggcttt
    12721 attgaatgga gaaggttcta ttatatatca ggtattaggt gcctttggaa tagaatcatc
    12781 taaactttta ggagatagta agacagcatt acctacactt atgtttatat ctatgtggaa
    12841 aaatataggg tatttcatgg taatttatat ttcagctata atgaatttac caaaacactg
    12901 ctatgaagta gcgaaggttg atggggctac aaaacttcaa gaatttataa aaataactgt
    12961 acctttattg aaaccaacta caataatggt tgtattttta gggtcgatat ggtcattaca
    13021 agtatttgac ttaatttata ctgtgacagg tggaggtcca ggtatatcta ctatgagtat
    13081 agttatgcat gcatttaact taaactttaa aaactttaat tctggatatg caatgactgt
    13141 agcaaacgta ttatttttgt taatagcagt agtttcgatt ttacaaaata agcttgtaag
    13201 acgagacaat tcagattttt agaaaggtag gtataatatg aaaacagcaa gaagattatt
    13261 aagtgatggt ttacttttat ttatagcgtg tgcaagtttg gtacctttta tatacatgtt
    13321 gataatatca ttgaagataa catataactc atatagtttg gatatatctt tttcaacagt
    13381 aacccttcaa aactatatag atatttttac taaaaaagga tttgcacaat atttttttaa
    13441 tacagcaata gtatcttttt caggtgtatt attaaattta gtatttagta cattagcagg
    13501 atattctttt gcgaagatgg attttaaagg tagtgataag ttatttttat ttatgataat
    13561 gactttaatt ataccttccc aagttacaat gataccacta tatataataa tgaaacactt
    13621 aggatggata aatagttatc ttgcacttat tatgccaata ccaactgcat ttggcgtatt
    13681 tataatgaga caagctattt taggagtacc aaaagagtta ttagaatcag caaagataga
    13741 tggttgctcg gattttagaa ttttaataca aatagtgttg cctttaatta aaccagcatt
    13801 aattacacta gcaatattta cttttatggg agcatggaac gagtttatgt ggcctcttat
    13861 agctacaact aaagatgcaa tgagaacatt aacagttgga ttatctactc ttaagacatt
    13921 ccagataact aattatggac agatgatggc aggggctaca ataacatttt tacctccatt
    13981 tattttctat ttgattttac agagtaaatt tgttgaaggt gtgtctttgt ctggtataaa
    14041 aggttaaata gtctaattta ataatatata aagaaactta tataaatatg gaggaattta
    14101 aactatggaa atttcatatg tactgaaaga ttgcacattc aaacacaata aatactcagt
    14161 tgtagaagct gaaacttgga aagataagga tttggatatt gtagtagcta aaggtgaaaa
    14221 atttgcattt caaattatgt taaaagcaac agaagaattt aattgtacaa ttgataaaag
    14281 tagtgctata tcatggaaag gcctgggaaa tagagtaagg ttagcattaa atatgcctaa
    14341 tagtttagaa aataatttta gtataaatat attaggatat gttcaagatg atacaaaggc
    14401 atttgtgaat gatgctattt taagggataa agatgtgtta gtagagcaat atttgcctca
    14461 aacattttgg attgaaggtc aagtaccaga agattttgaa gaaaataacc ttgatatagg
    14521 tattgatata tttaaaagct ttggatatga agacgaagaa aaagtttgta caattgatgt
    14581 tcctgtaaaa gtaagaaatg ttgtgctaaa gcctttagat gaaagcaagt tctttttaga
    14641 tttatggcaa catccaagct gtttagctag aatgtataaa gttgagttat ggtctgatat
    14701 acattttgaa atagtcgata actatttaaa agaattagca tctttaggag aaaaagttgc
    14761 aacagttata gtttcagatt atccatgggc agggcaaagt tgttataaag tttataaaaa
    14821 tccatcaaac ttatatgaat ataacatggt aagtgtatca aaaggattgg atggaaagat
    14881 taaatgtaac tttgagagta tggataggta tataagcata gctgataagt ataaaatggc
    14941 taaggagata gatttatttg gtctattagg taattggtgt gctggtgagt ttggaaatcc
    15001 tgtagaaggt tataaggacc ctataagagt aagatatttt gatgaaaagg ataaagtatt
    15061 taaatttata aacaatacaa atgatttaaa agaatatata ggattagtat taaatcattt
    15121 aatagagtgt ggattatggg acagagtaag gattatagct gatgaaccaa ataatccaga
    15181 agtagtcaaa gaatgtatag aatttataaa ttctactgta ggtactcatc aagttaaata
    15241 taaatcagca actcacgacc aaaacttttt agacagagct aaagatgaaa ttgatgatat
    15301 gtcaataaat ttaaaactta ctatacaaaa ttataaagat atagaaagtc ttaagaaaaa
    15361 aatcaatgac aagggtggga tattgacttg gtttgtatgc tgttttccag agaaaccaaa
    15421 tagtttttta agttctcctt ttgtagaaaa tagaataata ggatggtata cttattactt
    15481 tggtcttgat ggatttttaa gatgggacta taatttatgg acagaagacc cttggaaaga
    15541 ttcaagttac aaattcccta tttggaaagc tggagatatg ttctttgttt atcctggaaa
    15601 agatttaaag ccagttagaa gtgtcagaat ggagaattta agatttggaa tacaggactt
    15661 tgagttattt acaatgttag aaaaagaaaa gggaagagag tatatagaag ttgagcttat
    15721 gcaagaatta ttaaataaaa aagaaaatgc tgaaattaaa ggttttggtg acatagaact
    15781 aggatattca cttgataatt ggggatatga taaagttaaa aaatatgtat tagagttgtt
    15841 agacagagta taaaaaatat aagagtgtct caaaatgaac tttttagttc atgaggcact
    15901 ctttttgtat gaaatcaata tagtttcatt gtttcaacaa tgaaaaatag gattatttct
    15961 attctaagac agccctttag ttttttagtt gtattcaatg ttttaaaact aactataaac
    16021 gctataaagt ttataaatga caataattat atataacatg atgtacttta atttgctata
    16081 atagggattg aataatatta tatggaagat aacattgttt ggggggatta atataaaaag
    16141 aataggtatt attataatgt tttttttaag tatatctttt attggatttt atcttgtaat
    16201 aagagataac agtgatacag ttaagatgca acgagggata aatataggta atgcactaga
    16261 atcacctaag gattttccgt gggatgtaaa aatgtcaaat aagttttttg atgatataaa
    16321 agatgcaggt tttgacacag tacgtatacc agtaaggttt tctgattata cgtcagattc
    16381 tgataatttt aaaattgatg aagaattttt taaaaagatt gataaatatg tagattatgc
    16441 attggataaa gacttaatag ttgtgttgga tttacaccat tttgaagaaa ttatgaaaga
    16501 accaagagtt cataaagaaa agtttttaaa aatatggcaa cagatagcta ataggtatca
    16561 aaaatatgat aaaaaattgg tatttgaatt attaaatgaa cctaaagaaa atttatattc
    16621 acagttacta aacgaataca ttgaagaagc aataaagata attagaaaaa ctaaccctaa
    16681 aagaactatt atagtaggac catataattt ctatcaaatt gattatttga atgaattaaa
    16741 tattcctaaa gattctaata tagtagtttc ctttcactat tacgagccaa atgattttgc
    16801 atttcaagga aatatatatc ataagggatt tgagcactta agcaatatta cttgggaagg
    16861 aacaaacgaa caaatggatt atttaaaaaa aaggtttgat actgtggaaa attgggcaaa
    16921 taaaaataag gtaaaaatct tcttgggtga atttggaata acaaaagagg caccagaagc
    16981 ttcaagaaga gcatggataa aagctgtaag agaagaagct gaaaaacgaa acttttcatg
    17041 ggcttattgg gagcttgcat ctggatttgg tatatacaat caaattgaag ggacttggga
    17101 tagagatata ttaagtgcat taatagaaaa gaggtgattt tatgaagaaa aattcaaaaa
    17161 agatacttat aactttaact attattacta atgtcatata tatattgtgg agaatttttt
    17221 acacagtacc taaagaagaa gggaagtttg ccttaatatg tgccataata cttctttttg
    17281 tagagataat gggcatgatg gaaatgtttg tgcattatta tggtatgtca aatattgagt
    17341 accctgaaaa accaatcata agtgaagaac tttatccaca tgtagatgta ttcattgcaa
    17401 catataatga atctgttgat ttggtgagaa aaactgtaaa tgggtgtatt catatgcagt
    17461 atccagataa gaaaaaggta catatataca tatgtgatga tggaaatcgt gaagaaatgt
    17521 gtattctagc agaaaaaatg ggtgtaaatt acataactag aactgaaaga gaaggagcaa
    17581 aagctggaaa tttaaataat gcaatgcaac atacaaattc ccctttgatt gctacatttg
    17641 atgcagatat gataccaatg catgactttt taattgctac agtaccatac tttttgaaaa
    17701 atgagcaagc taaaaaagat ggagaaaaag aggagtatga aaaggttggt tttgtgcaaa
    17761 ctccacagag tttttataat ccagacttgt ttcaatttaa tctgcactct gaaggaagga
    17821 ttccaaatga gcaagattat ttttacagag acattcaatt ggctagaaat aggacaaatt
    17881 ctgtaattta tggtggtagt aatacagtta tttcaaggga agcacttgaa gaagttgatg
    17941 gattttatac ttattctatt acagaagatt ttgcaacagg tatcttaatt caaagtaagg
    18001 ggtatagatg ttatgctatt ccagaagtac atgcatcagg tttatctcct acagatttaa
    18061 aaagtcttat taagcaacgt gaaagatggg cacgtggatg tatacaaact ggtagacgtc
    18121 taaatatttt gtttaggaga ggtttaggtt tttggcagaa aataagttat atttcttcaa
    18181 ttacttattg gtatgcaagt ataaaacgct ttgtatatat aatggcacct attttatttt
    18241 ctgtgtttaa tgtgattgta gtaaaatgta cgttacttca agtattggta ttttggttgc
    18301 caatgtatat tttaagtagt ttatctctta aaatattttc tcaaaatata agaaatacta
    18361 gatggaccaa tatatatgaa actataatgt ttcagtcttt aatgccagca gtaatacttg
    18421 aaacgtttgc aatatctaaa aataaatttt cagtaacaaa taagagtaaa ttagaagaaa
    18481 atagaatgta taagttttta cagggaatac cttattttat ttacatggtc ttatctatca
    18541 taggaatttt aaaaatgttt gtagcaatat ttaaaatgag ttcaatgaca tattcagttg
    18601 tattattttg gttgattgga aaccttttta accttgttat ggctacatta tttatatcag
    18661 ggagacagca gttaagaaag tctgagcgtt atattgctga aattgatttt aagttaaagc
    18721 aaaattctta tgttctttct tcaaaaacaa ttgatatatc agaaaatggg tttgcatttt
    18781 tgctagaaaa tccagaatat atttccccag aagaagagtt tgaggtagag tttagagaaa
    18841 aatctggaaa tgaaatgtat atagctaata tgaaagcaaa gattgttaat gttgtggaag
    18901 taaattcaaa gtggaaatat gcagcttata ttacacatat tgaagatagt gaaatagata
    18961 attggatgtg tattgttcac gatagaatac ctactttacc aatgacaata tctaatcaac
    19021 taggtttctt tgatgatttg caaattaatg taaaaaaacg tattgaaaaa actagaacat
    19081 tatcacgaag aagtccaaga atcaatatga attttcagat ggatataaaa aatacaggta
    19141 aattaagaat agtgaatttt aattatcaat atgtattatt aaattttgag aataaaagta
    19201 tttatcctaa agaaatagca ttggaaatta atgaaaatat tgtgttagaa tgtgatttgt
    19261 gtgagggtaa aattgatgaa agaggtatct tatataaagt aaataacatt gacagcataa
    19321 tgcaaaattt ctttttaaga gatgaaatga tggattggat attacaaaat aagaaaattc
    19381 ttgattcaaa gcctagtgaa aagaaggaaa aaagtataga tgagtttgaa cccatggaat
    19441 atatttagga gagatgaaat gaagacttta aaagtgtttt tttgttctac aaaatatctt
    19501 attttggtgt ttattttttt tataaatact acttttataa gttcagcaac aagtgataaa
    19561 attttagatt tatcctttaa aaagatagag actgacttaa gttctaagat tacatatgag
    19621 gatacaggtg taaaaataga aacggatagt tctaaaagcg ataaggaacg ttatttatat
    19681 atttaccaaa atataaaaga aaattggagc atgtataata atttttatat tgaaattcaa
    19741 aataaaaata aaagttctca gagaataaat ttaagcatac aaagtaaaaa tatgcttgaa
    19801 tttagattaa aagaaggtag tgaagtattt ttagaaggta aaaatataat atattcagat
    19861 aaaataaaag aaggatgcat agaagtacca ggtgaatttg aaggcaaaat ttatgtgaac
    19921 tttaatagcc ttataaatga ggaaagtaat gttgtgctgg actcaaatat gctttcaaac
    19981 attgttagtt ggggaattac gtttattcca tctgatgaag aacataatat tgttattata
    20041 aaaaagatat ctttattgtc tgaagagaaa ttaagatttt taaataatat taaaataatt
    20101 ggcgatgaag aagtacaaat accagtattg ggtcaaagta taagtcagta tgaagtatta
    20161 ggtcttaaaa gtgattctaa aattaagtac tctcttatgg gaaaacaaga taatgtaagc
    20221 atatctcaaa aaggtaaatt aacattaagt aataaagcca aacctggaca aattatttta
    20281 caagttaatg ttgatgataa gtttaaaatt ggaaagaaaa taacattaac tgagtcttgg
    20341 agtgttaata aaaaagataa ggatggtgtt ccatatacat tagtatatcc tgagcaatca
    20401 ccaacagtac aagatatgaa aaaaataaac tttatgaata acatcataac gtttgttcga
    20461 attttatttg tatctctagt aataatatgc tttggaatat atttatattg gaaaaaatgt
    20521 tcaaaaacta agtaaagaga ggaggttaga ttgtgttatt ttcaagttta atttttttat
    20581 tttatttttt acctataact ttggttttat attatgtatt taggtttaac cgaacgatac
    20641 agaacatgat attgcttgct gttagtttat ttttttatgc ttggggagag ccaaaatttg
    20701 ttgttatcat gatagtttcc ataataatga actatatatt tggtttactg gtagatagat
    20761 atagggaaag taaaataaaa gtaaaagttt ttttagtttt gatgtgtgca tacaatatag
    20821 gtgttttatt tatatttaaa tatctagctt ttgcgctaag aaatattagt gaacttatta
    20881 gtactgaatt gactatacct agtattgttt tacccatagg aatttcattt tttacatttc
    20941 agggaatgtc ttatgttata gatgtatatc gtagacatgg agaagtccaa aagaaccctt
    21001 tttatgtggg attgtatata gcatttttcc cacaattaat agcaggtcct atagttagat
    21061 atgagagtgt ggcagaacaa attctcaata gaaaagaaac ttggaataaa ttttctattg
    21121 ggacttgtag gtttataaca ggtctaggta aaaaagtatt aatttcaaat aacatggcta
    21181 tagtagcaga ctatatttac actatgaata gtcaaggaga aatagctgca tcacttgcat
    21241 ggcttggttc aatagcctat actctgcaaa tattctttga tttttctgct tattcagata
    21301 tggctatagg cttaggtctt atgtttggtt ttaaatttga agagaacttt aattatccat
    21361 atatatcaaa atcaattagt gagttttgga gaagatggca catttctttg ggaatgtggt
    21421 ttaagagcta tatatacttt ccgcttggag gttctagagt agcaaataaa gatattatga
    21481 ttagaaatat gtttatagtg tggttattta ctggaatatg gcatggagca gaatggacat
    21541 ttgtaatttg ggggatttta aactttgttt tcctaattat agagcgattt ataatgtttg
    21601 aaaagattga aaatcacaat tttataaaac atatttatgc tttattagta gttaattttg
    21661 ggtgggtatt atttaggtca cctaatttaa aagaagcata taattatttt aaagctatgt
    21721 ttggaggcaa tggagctata tggagtgatt atacatatat gtttttaaaa gaatactggg
    21781 ttttctttat atttgcattt atttttagtg tacctattgc aaagaaaatc aataagtttg
    21841 ttgttgaaca agctaaatat agtatgatat ttaacgtatt ttatccaatc tcagctattt
    21901 tattgttttt tatttctgtg acatatttag taactggaag ctataatcca tttatttatt
    21961 ttaattttta gttgggagga aaagtatgaa tagatttttt aaagtaagat taataactgc
    22021 aattatgttc ttaattattt tattcgcttt ctctatcttt aatgtttgtt attctggaaa
    22081 agatacgata caggaaataa aaaattcaat agctgaaaaa agtagtttaa aagatacaat
    22141 atcatctatt gataatacag tgaatgacaa agtaatatac aaaaatacgt tcattgaaac
    22201 ttatggctat ttacaaaaat taatgggtaa aaatgagttt tcaaaattta gtgttgtaaa
    22261 agatacttct ggaaagatgc attatacata ttttgctaaa gctccaaatc cagttggtgt
    22321 gatagcagat agggtaagaa aattttctga tgaaatggaa aagcaaaaca ctaaattggt
    22381 ttacctaatg actccagata agtatataaa aggagtgaca aaatttccaa aaggaatacc
    22441 ttattcttat agtaatgaga cagcagataa ttttttaaat caactaaaaa agtataatgt
    22501 ggactatatt gattttagag aaaatatttt aaagagtggt attccaaaag atgatttatt
    22561 ttttaaaaca gaccatcact ggaaagtaga aacttctttt tgggcatttg gagaattagt
    22621 tgagcaactt aataaaaaat acaatatgaa tttagatgaa aatcattatt atagagataa
    22681 ggacaattat aattcaattg tatatcctaa gtcatttctt ggttctatgg gaagaaagac
    22741 tggtatctta tatggtggta tagatgattt tacattaatt tatcctaaat ttaagactaa
    22801 ttatacttat tatacagatt ctaaatctca aaaatttgaa ttaaaaggaa ggtttgaaga
    22861 gagtttaata ttatcatatc cttttaatgc agaccttgat ttaatggatg gtcaatcaga
    22921 taagtatttt acatatttat tggggaacag accattagtt aaaataaaaa atatagaaaa
    22981 tccagatgga ttaaaagtgc tgtttgttaa agattctcta attgtaccaa cagcagcatt
    23041 tttttcctct gtttgttcat ctatagatat gatagaccct agatattatg atggagatat
    23101 actagaatat gcaaaatccc atgactatga ctttgttttt atatctgtat atccccaaaa
    23161 tcttacaaaa gaattttttc cgttttgtga gtaaatttct aaaaaagttt tctgataaaa
    23221 taaatggcta actggtaaaa agttagccat ttattttgag tgttattcta agaaatattt
    23281 tttttactaa atacttcttt atctattttt ccaagtgatt ttcctacagt aattgatgat
    23341 accatagcac cattaacatt tatcatagta cgtcccatat ctagtatagg gtctattgca
    23401 agtataccac caactaatgg aaaataagaa ccaagaccaa ctccagagat aacaactgaa
    23461 acggccattg tagcagttcc tggaagacca gctattccaa acgaactaat tgttataaca
    23521 attaacaaca taacataaaa gctcatatcc atgtttactc cagccatatt ggcaagtgtt
    23581 acagccatta aagcaggata tatacctgca caaccattca tacccatatt tgcacctaaa
    23641 cttgctgtaa agcttgatac accctcatca actccgtgat tttgtactag actttctatc
    23701 gttacaggca atgttcctaa actagaacgt gaagtaaatg ccagaagtaa agcttcagtt
    23761 gaatttttta tataagtaat gggatttaga ccatttaaag ttataaaaat taaatgtata
    23821 ataaataata ttgcaactga tatataaaga gctaatataa actgtaaaac agatactatt
    23881 gaactaatac cttgtgaagt tattgtattt gcaagcagag caaccacagc ataaggcata
    23941 aatttaataa cagtcataga cacacttaca attattttgt aagatgcttc tataaaacct
    24001 ataaatggtt ttattgtttc aaaatgtttt ttacttaatc tctttattga ggtagctata
    24061 aatgtagcaa atattattgt agctacaata tttccatttg ccatagccat tacaggatta
    24121 gatggtagta atcctcttaa agtatccaca agagagttta tttctttaag ttcttgattt
    24181 tcaactaaag taggcatatt agctcctaca cctaacttca ttatatttgc aacgataatt
    24241 ccaacaattg cagctatagc agtagtagca agaagcatac ctaaagattt aaatgtcaga
    24301 gttccaagat tgttatcttt catatttata attactttta taatggataa gaaaactaaa
    24361 ggtactacta acatttttaa taagtccata aatccagaac caaataggct ataccactta
    24421 cttacttctt gtagccaaat gacttgagtt gtatcattag gaaaaccagc aaaagcttgt
    24481 attatgattc ccaatatgag tcctagtact gtagcatata ttgttctcaa tgaaaatttt
    24541 atttttttct tttcaaattg tctaacaata aagaacgtac ctagaagtaa tattatgaaa
    24601 aaaattgttt taaaatctgt aatcataaga aattgtgata aaaatgaact ttccaatatt
    24661 tttctccttt tatttaaaaa taaatttttc taagtttaaa tgatatcaat atattaaaaa
    24721 aatgtcaata ttatatcaca atttacttaa atagagtaaa acaagttgat tttgaaaaat
    24781 gtgattaagt acagaaaaat agggtataat aaatgtttaa agaatttgaa ttgtggtaag
    24841 aaaataaaaa atagctttta taagatttga tttcaaatta aaatgtgtta aataaataac
    24901 taaaaattat tataaaaaat gttttcatag aatatatatc aaatgaaaag cttaaaataa
    24961 gtgaagaaat taactagaca tcaaaggaga gataaaatga gagtaataat aattggtggt
    25021 gttgcagctg gtatgagtgc tgcagcaaaa ttaaaaagaa taaaacctga gtatgaagtt
    25081 gttgtttatg aaaaaactga aatagtatct tttggtgctt gtggattacc atactttgtt
    25141 ggtggatttt ttaatgatgc tgatgaatta ttagcaagaa caccagagaa acttagagaa
    25201 gctggaattg atttaaatat atttagagaa gtcgttgagg ttgatagtga atctaagaaa
    25261 ataaaagtaa aaaacataaa aacagatgaa atatatgaag attactatga taaattgatg
    25321 atagcaactg gagcaagaag tattatgcct cctataaaaa acataaaatt aaagaatgtt
    25381 tctacattaa aaagtttata tgatggagaa tatttaaaaa aacttttaag taatgaagat
    25441 aataaaagag tgacaataat aggagctggt tttatagggt tagaagcagt tgaggcatgt
    25501 aagaaattag gtaaagatgt agatgtaatt cagttagaag atagaatatt gccacaagta
    25561 tttgataagg aaatgacgga tgtattagaa gaagaaataa atagacataa tgttaatttg
    25621 cacttagatg aaatggttgt agaactttgt ggagaagata aagtagaaaa agttataaca
    25681 aacaaagggg aaatagatac agatgtagta ataattgcta ctggcgtgag acctaatacc
    25741 gagtttttgt caaatactaa tataaaaatg ctaaaaaatg gagctatagt agttgatgag
    25801 tatggaagaa cttctgtaga agatatatac tctgctggag attgtgcaac tataaagaat
    25861 atagtaagta atgaaaatgt atatgttcct ttagctactg gagctaataa attgggtagg
    25921 atagtaggag aaaacctagc aggaagagaa atatcttatc aaggttcact atcttcaagc
    25981 tgtataaaaa ttatggatat ggaggcagca tcaactggaa ttacagaaag gcaagctaaa
    26041 gatttaggca taaatgtcaa atctaaattt atttctgatt ataatcaaac tcattattat
    26101 ccaggaagaa ataaaatata tgtaaagctt atttatgatg cagatacaaa agttatttta
    26161 ggcggacaag tggctgggtt taaggatgct gtccaaagag caaatgtatt ggcagctgct
    26221 atctttggaa aaatgaccac aaatcaactt ggaatgttag atttatgtta tgctccacca
    26281 tttgcaagaa catgggatgt tttaaatgta gctggaaatg tatctaaata atatttagat
    26341 tatagctaat atagttgaca agcaattaag ggaatgaatt tacctaaact atttttatca
    26401 tggtaaaatt cattcctaaa tttttattcc aaatttttat tccaaatttt tagaaataag
    26461 gattccatta aattattcat caaaatttaa acgcaagctt aatctatctt ctccaagaat
    26521 agtattttca aaaacattag tagcattttc taaatacata ctaggtatgt ctaaagaagg
    26581 actaaaatga gtcagtaaaa gttgtttgac atttccaagt tttgcaagat tagcagcttc
    26641 tctaaaagtc atatgtttgt ttctaacagc ttttgatata tctaaatcat caccatacat
    26701 ggcttcacat ataaataaat cactatcttt tatgaaatct ggtattgatt ctataggtct
    26761 tgtatcggtt gtaagactta tcttaactcc ctttctcaat tctcctaaga ccatatctgg
    26821 agtgtattgt tttgaatcta aaactatatt ttgaccttct tggagtttgt tccataatat
    26881 tttaggaact tcgtttttag ttgccttatc tatatcaaat ttagggtttc ttctaaaatt
    26941 aaaactgtat cctaaacact ctatagagtg ttctaaactg attgttgaaa tttctaaatt
    27001 tcttaaaact ttattatcta aagaaaaatt gccttgaggg ttttctataa tttttaaagt
    27061 gtatggtaca tattctacta aatttctcat agaacgtata caatcgacta ttccaactgg
    27121 accaactata gttaaatcac ttgtacgacc actattccca attgttgata aaagtcctaa
    27181 aagtccaaat atatggtcac catgtaaatg ggttatacaa atcaagtcta tatctttaaa
    27241 gccacatttt tttagcttca tagatacctg agtaccttca ccacagtcaa ttagtatttt
    27301 tctaccttta tagtttataa atacagagga tagaaatctg tttggcatag gtacatttcc
    27361 accacatcca agtaaagtta aatctatcat tttttcccct ttctaaaatt aacacaaatc
    27421 tgttgtttgt ttttattatg atatcctatt ataattattt taacattaaa tataacaata
    27481 aatgtgtatt tgagtcaaga aatattgtca aataaagttt ttatatagaa atgtataaaa
    27541 atttggaaaa caaaaagtga aaattatatt taggagcatt taaaggagga aaatttaatg
    27601 aaagtattaa agaaaattac tattttgtca ttgattacat taaccttagt tggttgtagt
    27661 aacggagaag ataaaaaagt ggttgaaggt tctaagaaaa ttcaaaattc taaaaaagat
    27721 gaacagccta taatagtaca taaagatgca aatatattga aagataggta tgagccacca
    27781 aaaggattta aaagagttga tgtagaaaaa ggtagttttg aatcatttct taggaatact
    27841 aagctaaaaa attatggaga gaaagtaaag tattatgatg gaagaactaa ggaatcaaaa
    27901 ggtatttatg atagtgtatt tgatgttgat attggcaata gagatttaca tcaatgtgca
    27961 gatgcgatta tgcttatgag agcagaatac ttgtatcaga ataaactata tgatgaaata
    28021 agttttgatt ttgttgatgg ttttaaggcg aagtattcaa aatgggcaca aggatataga
    28081 atttcagtaa aagatagtgg ttcaagctgg tataaagcaa ctgaatattc aacatcttat
    28141 gagagtttta gaaagtttat ggatatagtg tttgcatatt caggaacgtt atctcttgaa
    28201 aaagaattgg agcctgtaaa agttgaggat atgaaaatag gagatgtgtt tatagttggt
    28261 ggaagtccag gacatgcaag tataattatg gatatggcag aaaatgaaaa gactggtgaa
    28321 aaggtattta tgatagccca aagctatatg cctgcacaac aaacgcaact tcttattaat
    28381 cgtaaaaatc caaatttgag tccttggtat agtttagatt ttgaaggtga tttgacaata
    28441 cctcaatgga cttttaaaag agaccagttg aaaagatttt aaaataataa ttttatataa
    28501 taaaagaaaa atatagatgt gaaaaaatgt aattagatta aaactaattg gatatggaca
    28561 aaattaaatt gatagataaa tattaaaaat tacactaatt aatcttacta tagtttaata
    28621 tttatctaaa aagttttatg taaaatataa attttatatt aaagctaaaa ctaatttgag
    28681 gaggctaatt tatattgaag attagaaggt atttaatttt ggtaattata attctaatta
    28741 caacaagtca gagttttatt tcttatgggc tagagcgatt tgaagaaata accatttttc
    28801 acactaatga tatacatgga agatatgctg aaggtgatga ccatatacaa ataggaaatc
    28861 tagccacatt gaaaaaagaa actccaaact caattttagt agatgcagga gattgtttgc
    28921 atggacttcc aatagtaaat atggatagag ggaaaagtgc aattgaatta attaaatgtg
    28981 ctggatatga ctatattact cctggaaatc atgactttaa ttatggaaaa gatagactgt
    29041 ttgagttatc taaaagtgct aatttaggag agaatacttt aaaattttta tcatcaaata
    29101 tttttgaaaa tggaaaaaaa gtttttgata gtaatgatat aaaagaaata gatggaataa
    29161 aaataggatt ttttggactc tcaacccagg aaacaaagag caaaactgga tttaaaaatg
    29221 tggaaggatt agagtttaaa aatcctatag aaagtgcaac agaacaagta aatgaattaa
    29281 aaggaaaggg tgccaatgta atagttgcaa tatgtcatat tggtacaaat agtttaagta
    29341 agccaaatag tatagatata gcaaatgagg ttcaaggaat tgatttgatt attgatggac
    29401 acagccacac taagtttgaa aatggtaaac aagtgggtga tacattgatt gtaagtgcag
    29461 gacaatattt agaaaatatt ggcgagataa aactaacttt ggatactaat gatgtagaaa
    29521 atataaaaat agaaaataaa tcagttagat taattggaaa agaagaagca ttaaagtata
    29581 agcttgactc cgctgtaagt aaaaaggttg atgaaataaa agaacaacaa gaaaaaatat
    29641 tagataaagt tataggggta actacaaata ctctagatgg ttcatatgaa aatgtaagga
    29701 caaaagaaac taatttgggt aatttaataa gtgacatttt actagataaa actaaggctg
    29761 atatttcttt atttaatgga gggaatattc gagatacgat agaaaaaggc aatataacaa
    29821 gaagagatat tgtagatgta tttcctttta acaatactat agttaccaaa gaacttacag
    29881 gagcacagat taaagatgta ttggagcatg gagtaaaact ttacccagaa aaaagttcag
    29941 cctttttgca agtgggagga atttcatatt actttaatcc taaacaaaaa gaaggcgaaa
    30001 aaataacaaa tattcaaaaa gaaggaaagc cattagattt aaataaaaag tatgtagttg
    30061 caacgaatga ttatatagca tcaggtggag atgaatttcc ttgtttttca aaagagccag
    30121 tactaaagga atttggaaat ttagagagtg cagtcattga atatatagag tacaaaacag
    30181 aaatatcaaa aaatgtagat ggaagaattg gtattaaatc taaagatgag ttaataagca
    30241 agaatcatga gagtgatttg atattaagtg aaaatgaaaa aaatatcaat gataatgaag
    30301 agaatctatc taataatata aaaagctctg atagtgataa aaataaaagc ttagataaaa
    30361 caagtgctag agaaagttct aatctaggaa tatctaaaag agaagctaaa gaaaaatctc
    30421 ctaaaacagg agatttaggt ttttcaaata gtataattat atttatagtt tcaagtacat
    30481 tgatatgttt attgaatttt aatcaaaaag agttaaagga taaaaagtca aaataaaaat
    30541 taatgagcaa aaactagtag atagtaattt aattttagat aatagtaaac agcaaaggaa
    30601 attagttata taaatactaa tttcctttgt tttatgtttt aacatgatta cttttaaata
    30661 aaattgtatt ttatgaaaaa taattacact aaatggcata gtattatggg gatttttagt
    30721 ttttattcaa gtaaatgaaa tcatattaac aacttctgat atatttacaa attgataaaa
    30781 aaatgatttt attagtatga tataatttag ctagtatata tgatgatgga ggatataggg
    30841 atgaataata tattactttt ggaagatgac aaatctttaa atagaggaat tagttttaaa
    30901 ttaaaaaaag aaggatacaa tgtttttagt gcatttggta tagaagaagc aaaaaatatt
    30961 ttcgcaaaag aagagatatg cttaattatt tccgatatag gtctacctga tggtagtggt
    31021 tttgactttt gtgaggagat tagaaagaaa agtgatgttt acataataat gttgacagct
    31081 cttgatgaag aggtggatat tgtcacagga tatgatttag gtgcagatga ttatatcaca
    31141 aagcctttta gcttgatggt attaatatca aaagtgaatg cgcttatgaa aagagtaaat
    31201 acagtaaaaa attatactct attagtttgt gatgatttat tcttttatta tatagaaaat
    31261 aaattaatta taagaacaga tgataaggaa gaagagataa ttttaagtaa gacagagaca
    31321 aaactattaa aatatttgat ggaaaattct atgcagacat tgactaaaga gcaactgtta
    31381 gaatctttat gggatagtag tggtaatttt gtagatgata atacgattgc agtaaatata
    31441 agaagactta gacaaaaggt tgaaaaaaat ccatctgaac ctaaatatat aaaaacagta
    31501 agaggggttg gatatatgtg gggagaaagg agtataaaaa aatgctaaaa aatatgaacc
    31561 tcaaagatgg tttaagtgtg aaagatgatt atataatgag aagagttatt gtatattctg
    31621 ttttatctgt actaatagta acccttgtat ttatactttt tgaatatagc agattacata
    31681 aattgtatga acatcaaata aaaaatactc aaaatattgc tggaatattg attgaaaaat
    31741 atcctaatga tgaaatagat atagtaaatt ctatttataa ttctgattat agtaaggtgt
    31801 ctactggaga aaaggcattt aagaaatttg gctatggatt ggaaaataaa atgtcaaatg
    31861 ataaaaattt tagcttatac ttaaaatctt tttttaagga atcatttttt atttttttaa
    31921 tgatgtttat agtagttata ggtataatat attattttat aagatacata aataaaagat
    31981 tgagtaaaat ttattttata gtagataaga tgtcacaaga aaactacttg aaggacacta
    32041 ctgagtcaga agaaactggt tatctagtag aatataatga atactttaaa gaaggcatat
    32101 ttagtaagat aaataactgt ctatatgagc ttaatagaag tttaaagata aagtttatta
    32161 aattagaaaa agaaaaagaa agtgtaaaat cattagtaac agatatttcc catcaattaa
    32221 aaactccttt agcatcctta aaattataca atacattact tatagaagaa gaattagaag
    32281 aagatgaagc caacgagttc ttattgacca ataaggcttc tataaataaa ttagaaaatt
    32341 taataaattc tttagtgaac atatcaaggt tagaaattag catgataaac ataaaaaaag
    32401 aagataatga tataaaaaat actattctaa atgcagtaaa aagtgttacc cctaaggcta
    32461 agagcaaaag tataacatta aatttaaatg aatttaacag tagaattata ccacatgata
    32521 aaaagtggac tgaggagagt atttttaatg tattagacaa tgctgtaaag tatacacagg
    32581 taaatggaga aataaatata tctgtagaag aaactgctaa tttctttaaa attataatag
    32641 aggataatgg catagggatt gaaaaaaatg agtttaataa tatatttaaa cgtttttata
    32701 gaggttctgc tgatgaaatt gaatctgtag aaggtagtgg ggtaggattg tatttaagta
    32761 gaaagatttt agaagaacaa ggtggaaata ttatagtttc ttcaaaagta ggaataggga
    32821 gcaagttttc tttgtttctt acaactatgt aatattaaat gaaaggaaaa tgtaagcctc
    32881 tacatttatt atataagtat aaacagctcc agaaataaaa aattaataaa atatggggta
    32941 atataactta gaatgagagg ataattttat gaaaatacta tatactgaaa atttatcaaa
    33001 gcattatgga aaaggagaaa gcttagtaag agctttggac aatgttgatt tagaaataaa
    33061 tgaaggtgaa tttgttgcaa taataggaaa atcaggttct ggaaaaagta cacttttgca
    33121 tatgattgga ggtcttgata tacctacatc tgggaaggtg tatatagata ataaaaatat
    33181 atttacatta aaagaagaag aacttgctgt atttagaaga agaaaaatag ggtttatatt
    33241 tcaaagctat aatttaattc catctcttaa tgtatgggaa aatgtagtgt tgccaatcgg
    33301 tttagatggt agagaggtag atgaatcttt tataaaagaa cttttgaaat cattaggact
    33361 tgaaaataaa cacgacgttt taccaaatac attatcaggt ggtcaacaac aaagggtggc
    33421 aatagcaaga gcattagcta caagaccagc tataatactt gctgatgaac caactggaaa
    33481 cctagattct aaaacatctg atgaggttat gagtatatta aaatctatgt ctaagaagta
    33541 cagtcaaact ctagttatga taactcatga tgacagtata gcccaaatgg ctgatagagt
    33601 tatattcata gaagatggca gggtgtcaaa ggttggtgat aaaaatgatt aatactacta
    33661 aaatagcaaa aagtaattta aagcaaaata aatcaaaaag tattctaata ataattacta
    33721 taatactttc aaccttaatg ctttcttcta ttggaattta tattgttgat gcaggagcat
    33781 atcaaaaaga aaatactata aagtattcag gcaattatca aggtatatta gcaaatgtag
    33841 atgaaaaaca ggctgatata ttgagtaatc atgcagatgt tgaattaact ggtgaaatga
    33901 atggagtagg tgttgaaaaa ctggaagatg attcaaatat ttctctagca tacatgaatg
    33961 aagatgcttt gaaattaaat agttttgaat ttatcaaagg aaaattgcca tcaaaagaga
    34021 atgaaattgt gttagatagt ggagctttaa aggcacttgg ttataaaaat aaagatttag
    34081 gtgaaaagat aaaaatatct tatgatgact ataaaagtga taaaaaaatt gaaaaagagt
    34141 tcattataag tggaatctta aaaactagcg aaatatctga agcaggtaaa tattattatg
    34201 ctattatatc agaatcatat atgagaaata ctagagatat gtcgcaagaa gattttaata
    34261 tatatgtgaa attaaatgat aaaagtaatt tatcgataga acaagcaaaa tcaaaattaa
    34321 ataagattgc taatgatgta ggattggaca ctattaatgt agctgtaaat gaaaactata
    34381 taaatgcttt aaaaccagat atggaaacaa ttatgggtgg agtatttgta gggttagtaa
    34441 ttgtattgtc tagtatttta gtaatataca atatatttta tatttcaata gttacaaagg
    34501 ttcaagaatt tggaaagctt agagcaattg gtgcaactaa aaaacaagta aaaaatatag
    34561 tatttaagga agggttcata ttagccggaa tagcaatacc aataggaata attttaggct
    34621 atgtacttgc aaatattata ataaaatcat ttatggatat agatgtaaaa tcatcacgat
    34681 taccagttat attatcggtt gtggtaataa gctttatatc tgttgtttta tcacttttaa
    34741 aaccaatgaa agtagcatca aaagtatcca ttgttgacgc agtaagatat acaggaaata
    34801 aaataagtaa taagagtaag agaaaaggat ataaaaatat aaatctaaag agattatcac
    34861 atgccaattt agaaagaaat aaaaaacgta cttacatgac attggcatca cttatactta
    34921 gtggaactat atttataaca gtatcaactg ccttagaaag ttttgatgct gagaaaatgg
    34981 caagagaaca ctttccttat gatatagaag ttagactatc tggttatgaa atgaacagtg
    35041 ataaaaatcc taaagataat ttgaatattt tacaaatgga taatcctcta agtaaagatt
    35101 tttttaatca aataaagaac atggaaggaa ttaaaagaat agaatctgca agaagtgtaa
    35161 aaattggtat ggaggactat gatgttgaat ttaagtatga ccttttacaa agtataaatg
    35221 aaaatgatgt aaaatcatta aacaagaata taatagatgg aaaaataaat cttgaaagac
    35281 ttcaaactgg agatgaaata gtaattactc atgttgatac agcaaaagaa atgggagtaa
    35341 aagcaggaga taaaataaga ttaactttat atgatggaga taaaaagata aaaaaagaat
    35401 ttaaagttca agcaatagct atgggggttc caagttttgg tatagggaag gattttattg
    35461 atagaacttt gaaatacgat tcaactagta gcttgggaat atatacagaa gaaggaaagt
    35521 atcaagaaat caaagatagt atcaagaaga ttgctaaaaa taatggattt ttagagactg
    35581 attttataga tagtagaatt gagtcaaata aggctactat ttcatttata aagataatgg
    35641 gatacacgct aacaggcata ataggtgtga ttggatttat gaatcttgtc aacacaatga
    35701 taactagcat agttactaga aaaaaagaac ttggtatgct tcaagctatt ggtcttacta
    35761 ataaacaatt agtgaaaatg cttaattcag aggcaatgta ttacacttct ggaatgatga
    35821 taggaagtat tctatttgga ggtatattag ggtatattgc tgttatattt ctaaaaaaga
    35881 ctggattatc ttatgcaaca tattctttgc caatagtacc aatcttgttg atgattgtgt
    35941 gtattcttat agctcaattt ataacaactt atttgatagg acgaagtttt aataaagaat
    36001 ctcttattga tagagtaaga tacagtgaat aaaatacaaa tatttatggt tagtttaact
    36061 agcaaaaaac atataaaaaa atatagttaa agagattcat aattaaatag gttaaagcat
    36121 agtacagagc aaacaattta agcagatgtt tgctctgtat tttattatgt aatcaataat
    36181 atatctaata tactgatatt attcatgtta gaaaatgtac cggtacaatt ctaaaaaagt
    36241 ataaaattgt accatataaa atgaaaattt tgtataataa tcgtatagaa aataaatagg
    36301 agctgatata tatgaataag aagattaatt atgcaccagg accaactgaa actagggaaa
    36361 atgtaagatt agcaagagca gaaaaaacaa caaatccaga tatagatatt gattttgttg
    36421 aattttataa aaagacatgc gagaagtttg gtaatataat tggaacaaaa aacgatgttt
    36481 acatattgag tggtgaagga atattaggtc ttgaagcagc atgtgcatca cttacagaaa
    36541 aaggagatag agtacttgta attgacaatg gtatatatgg agaaggtttt aaagattttg
    36601 taacaatgta tggtggggag tatgtgcttt tttcaagtga atatactaaa agtatagata
    36661 ttgatgaatt gaaagcattt ttagatgagg atagtaattt taaatatgca acagtagtgc
    36721 attgtgatac tccaactggc gtattaaatg atgtaagcaa aatatgtcca ttacttaaag
    36781 aatatggaat attaactgta gttgattctg tagcaggtat ggtaggagaa agattaagtg
    36841 tagatgaatc taaaatagat ataatattag gtggttcaca aaaagctatt tctgcaccag
    36901 caggacttac tatagtcgga ataagtcaag atgcaaaaaa ttgtataaaa aatagaaaaa
    36961 ctgatgtaat aggtttttat tgtaatttaa atatatggga aggctattat gaaaaaaaat
    37021 acttccctta tacaatgcca ataagtgaca taatggggct tgataaagca cttgataata
    37081 tattagaaga aggaatagaa aatgtattaa atagacatga aaagatagct tatagtgtta
    37141 gaaaatctat tgaggaatat ggtctagaac tatttttaga agaaggatat tctaatacag
    37201 tcacagctat aaaaattcct gaaagtatag gagctttaga acttactgat tatatgctta
    37261 aaaattataa tacacttgtt gcaacatcac taaatcaata tatggatact attttaagaa
    37321 taggtcatat gggagagaat gcaaatctaa ataaaataga acatgtacta aatgttttgg
    37381 ataaaagttt aagtgcatta ggattcaaag gaaatggaaa tttgttaaat ttatttaata
    37441 agtattattt ttaatagata gggggatata gtatggaagt tacagctaag caaaaattta
    37501 caacgaaaga catggtggaa acctcactat taatagcatt agtatttatt gcaactaaat
    37561 ttataaacat aagattacca atatctataa atggtgggct tgtgcattta ggaactgcaa
    37621 tgttgttcat atcagcaata gtatttggaa gtaaaaaagg tgctttatca ggagctattg
    37681 gtatgtcact ttttgatttg atatctgggt ggactttatg ggcaccgttt acctttatag
    37741 atagaggagt tatgggttat ttacttggaa agattgcatg ggcaaatggt aataatggga
    37801 ataatttttt aatcaatgta ataggaatat gtgtttcatc aatttggatg ctatttggat
    37861 attatgtaac agaagttata ctttatggta attttatagt acctcttact tcaataccag
    37921 gtaatttaat gcaagtattg ataggtctta taatagcgct tcctatttct aaggtattga
    37981 aaaaatgtat aaaataaata taaagtgaac taaaatttat gatagcataa attatactgt
    38041 ataatattag gatggagtac ataattaaaa aattttagta tagaggttag ttcacaatgt
    38101 tatcagttac aagatattca atcaaaaatg ttcgtttaaa gccgtgggta aagtttattt
    38161 ggtattttga gacaaaatca aatatactgt taaataataa gttacttccg acagacagta
    38221 tagatattat tctcaatctt tctgatgtta tggaatataa aattgaaaat caagactata
    38281 ttgctagtaa tattcatttt aatggaataa gggataaaca tggatttatt attcaacatg
    38341 gaaatatacg tgttataggg atttcttttt atccatttgg tctctatcca tttttaaaga
    38401 taccaatttc agagtttaac agacaaattg ttgacctaga agcagtatca aaactatttg
    38461 caaaaaaatt agaagagtca ttaaatccaa caaaagcaat agaaaaagtt gttttatgtt
    38521 tagaagaagt attattatcc atattagaag aagatttaat ttcaaataaa tatgtaaagc
    38581 ttctaaattc atttatatat gttaatagat atagcaatat aaaagcattt tgtgatgata
    38641 caaatataaa tattaaaaca ttggaaagaa tctgtttaaa atatacaggg tatacaccta
    38701 agattttaaa gagaatttac agatttaaaa tggcaagcaa tcaacttatt tataattata
    38761 aagatgatga actttttgat tttatttatg aaaatgagta ctatgaccaa gcacacttta
    38821 taaaagaatt taaaaaattt tcagggacgt caccaattaa atttagtggt gagaataaga
    38881 cgattaaaga aaatataaag tacagctatt tataattata ctgtcgattt tttacaatac
    38941 ctccaattta ttttttgata tgatatagga aaataaattg gaggttttac atatgaaaat
    39001 tattacagaa atagttgagt ttaatgtgga agaaaattta tcaaaagaag agtttataga
    39061 aattgtaaat gacttagaat taaaatttca ttctattcaa tctggtttta ttgatactga
    39121 acttttatat gatgaaaagt ctcaaaagtg gattatgata caacattggg aatctataga
    39181 agacctcaag agtgtttcta gtaaaatgtt taaagattct tcaactgaga aatttagaaa
    39241 agctttaaag aatcaaactg ttaagatgaa tataatacca caaattaaaa gttggaaatt
    39301 atagaactga atgtaaaaga tagttaaata gtatcaaact aaattagcca aataacattt
    39361 tgtatttaaa ttgttatttg gcttttagtg tttattttaa tatgagtgtt atatactaga
    39421 aaaaccaaca aactgttaga gtgtggatta tcataatgtc atattcggga gctaaaaggc
    39481 ttaatactga tttgccaatt ggtcaatcca tgcatgtcca tctggatatg ctgttattaa
    39541 agcatttaca agccaatccc tttgctcttg tgataatagt gggactgtta catcgaagtc
    39601 tttttgataa ccaagcctat ctatgtatat tgatttgcaa aacaaaacca cttcgggagc
    39661 catatatggg atattatctg atgttatcag tctggcctta tccatatctc ttataattct
    39721 ttgattttgg gaaaaaagaa attttccatc tttctgtgga ttatatatca attcaataaa
    39781 atcgaactgt aactgttcgt cacactgtat attcatttta tagttatcat cctcgacttt
    39841 ttttaattca ataaatgagc aatcaggctt aatcgcaaaa acacaaattt gctctatatg
    39901 ttgcttgtta aggtcgataa taggtcgtaa taaataatta cccaagggct catatatatc
    39961 ccatccttga ttaagcatat actgaatgct cttttcttta tctgtgtcag aaatccatat
    40021 gtcaatatca ctgtgtgggc gaatatgcat attcgcaaat aattctaggg catatccacc
    40081 acatattgaa tatgaaaagc cacaatcatt aaaaaagttt acacaatctt taattagttt
    40141 gttcatagca acctcctttt gcatgtactg aaataaatta aattttttaa aataccaact
    40201 aaatgtttgt tttgtgtaaa tataaaactg ccgatattaa ggcagtttta tatttactat
    40261 ttagaaaatt tattaacaaa tttttgatat tcacacatta tcttatcatt cataaaagaa
    40321 atacccataa aagcagcttg ctcaccaaac aaagtaaaac gttctatcat ctgttgtgga
    40381 ttacctggat aaactgttgg aatacaccat gtgtttagaa gaaaaccaaa catttgagca
    40441 gcaatctctg gatttttaac ttccatagaa ttatcttgat ttccttcttc aatcaatgct
    40501 tttatccaag gcacaatatc atttataatc tcatcaaact gcgtagctaa atacttagga
    40561 ttacgcaata gtgatgatga cattaaaaaa atgtcttgtt tattgtgctg ttcataagca
    40621 tgaagcaacc tatattgtaa tttttctaat gcggtctttc cttcatcatt ttttacctca
    40681 tacccataaa atccatcatt atacaaccga cttgtgattg ccttaattat ttcgtctttt
    40741 gatttaaagt gatgataaat agcacctctt gaaaggccat ctaaattatc tacaatgtct
    40801 tgaatcgttg tctgctcata ccctttttct aagaataact tatgtgaaat atcaagtatt
    40861 ttttgtatag tattatcagg ttcttttttt cttcccaaaa aactcactcc tcgaaacaat
    40921 catttggtat gtttatctta gcaaatacat aatgatttgt caatgtgtct ttttagcatg
    40981 ttgaacaggt atattgccat gctttcatta ttttattttt ttgccttata ctggactata
    41041 tttgcagttt cctaatatat ttggctcata tttaaatacc attatctaaa agcactattg
    41101 ctgtacgaga ggcaataggc attttagaag aaggaggagt tgagctaaag tatacatcat
    41161 aatctcttaa gttttctttt tttgtgtttc ctccaaactc taccatatca gtatttaata
    41221 tcgttttgta gtttgtattt tgaaactttg aaatatcaac tgattgtatt agattagggt
    41281 ggaaattaaa tataaataaa tatttgccct tactgtacac caaaatcttt ttatcattat
    41341 ccatatgtat aagttcatga ctattttgga taaaaatatc actgtatttt gtaagttcga
    41401 gcatagattt atcaaaattt aataattgtt tatactttaa gttgttatct tctgaaaggc
    41461 tccattgtct tctggcatac ttatagctcc aattgttgcc ttctcgtgga aaatcaatcc
    41521 actcaggatg tccaaattca tttcccataa aatttagata tccttcacct gctagagaaa
    41581 aagttattaa tttaattaat ttaataagag atattgctct attgataaca tggttatttg
    41641 agtttatttc catattccag tacatttcct tgtcagctag ccaaaaaata attgttttat
    41701 cgccaactaa tgcttggtca tgggattcac aatatcctat atttttttct ccaggtcgtc
    41761 tagtagtaag ttcataccac attttgccca aatcccagtc ttcatcagat aagttagaga
    41821 tagtttttat ccaaaaatca ggtactccca ttgcgagtct atagtcaaat ccaattccgc
    41881 cgtcttttat agggatacac ataccaggca ttccactcat atcttctgca atacttatcg
    41941 aattaggttt aatttctttc attaattcat ttgcaaattg gagatatgtt atagcttcaa
    42001 tatctgtatt catactaaaa tatttttcat aactatcaaa tgaaactcca agaccatggt
    42061 tatgatataa cattgaagtt acaccatcaa acctaaagcc atcaaaatgg tactcattta
    42121 accaaaattt tatatttgaa agcaaaaaat gtattacttc aggtttacca tagttaaaaa
    42181 gttttgtacc ccaagcagga tgatttccct ttgaacctga gtggaaaaat tgatgttcac
    42241 ttccatcaaa ctcatttatt ccttctaaag tattctttac agcatgagaa tgaactaaat
    42301 ctaataaaac agcaatcccc attgaatgag cagtgtttat gaggtttttt aagtcttcag
    42361 gagtaccaaa cctagatgag attgcataaa agtttgaaac ttggtatcca aaagatgcat
    42421 aatatggatg ttccataata gccataagct gaatggtatt gtatccagct ttttttatct
    42481 taggaagtat tttttcagta aattcattat aagttccaat agattcgctt tcagtagaca
    42541 tacctatatg acattcatag attagtggag aagttatgtt ttttaagtca aaatcattgt
    42601 cagtccagat aaatggagtt tttggttgcc atatttgtcc attaaatcca ccaaaatctt
    42661 tttgaattac tctttttata tataatggta tacggtcaaa tgtttttcca tttgcagtaa
    42721 cttgtacctt tacctctgat ttgtgaggta agctattttg accaggaata aatatttccc
    42781 aattaccaga cccaattttt cttagaggat gagattttct attccaatta ttaaagtcac
    42841 caattagtga caaactatct gcatttggag cccattccct atagaagaat ccatcatttg
    42901 tctgatgaaa tccatagtaa agatgagcat ttgcaaaaga actaaaatct ttatagtttt
    42961 tcaatgtttt tgatttcata tcctcataat gtttcattcg cttttttata tcagattcaa
    43021 atggttgtag gtatacatca atatctaaaa ttttaaatct tttttgactt ttcattgtat
    43081 ttctcctcca taataaatat tacatctaaa aaataatatt tatctcatac ta
//
LOCUS       DAEQCW010000023        41858 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.023, whole genome shotgun sequence.
ACCESSION   DAEQCW010000023 DAEQCW010000000
VERSION     DAEQCW010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 41858)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 41858)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..41858
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.023"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            55..696
                     /locus_tag="KRO40_001254"
     CDS             55..696
                     /locus_tag="KRO40_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBH2092076.1"
                     /translation="MGNTFYIVRHGQTDWNILGKTQGHGNSDLTPQGIEQAKELSEDI
                     GKYSIDYIFSSDLGRAMQTAQILGDKLNIEVQKTEALREMGFGVWEGLLIKEIQKDYS
                     DIYATWRNEPHLVNIPEGETLKIIKERVDAFIKELNEKYDNKNIILVTHSITLRVMLL
                     SFLESGMENIYRIKQDNTALNIVEFKDYGPVIVKMNDTSHIKNHVKINNSALE"
     gene            720..1973
                     /locus_tag="KRO40_001255"
     CDS             720..1973
                     /locus_tag="KRO40_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH2092077.1"
                     /translation="MSKVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATG
                     GGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLISYFESRNLEYKIEEENDHK
                     VYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALKDDSNKDKSKYLIKGI
                     ILDNGDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKW
                     IKDLQGISMKNVEISCKIKKRKISKSGDMLFAHFGITGPCVLIMSSYINKIIEKEKVE
                     LNIDFLPNLSTDEISSIIRAFPNKNVLNNLKQILPQNFLKEIFSLLSLVDKKASDLSK
                     ADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVI
                     DIDAETGGYNLQIAFSTGYLAGISV"
     gene            2019..2669
                     /locus_tag="KRO40_001256"
     CDS             2019..2669
                     /locus_tag="KRO40_001256"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HBH2092078.1"
                     /translation="MGNLVIAVDGPAGAGKSTIAKIVAKKLNINYIDTGAMYRAVTYK
                     CLKSGIDVNNEKEVIQIAENSDIDFKDNNIYLDKEVINEEIRTIEVSNNVSNVAKIKE
                     VRQLMVEVQRKIGMKNSVILDGRDIGSYVFPDADYKFFLVATPEERGNRRYKELCNKG
                     YNTTLEEVIEDIIRRDEIDSNREFAPLVKANDALEIDTTGKTIEEVVEEVVSKINL"
     gene            2720..3316
                     /locus_tag="KRO40_001257"
     CDS             2720..3316
                     /locus_tag="KRO40_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBH2092079.1"
                     /translation="MNFYRFVINIFKGFSKIFFKYEVIGAENIPDRGNIVIASNHKSN
                     LDPIFLAAAIENREIAAIAKKELFKVKPLGFILKKLHVMPINREKPDVSTIKTILRSV
                     RDGYVLGIFPEGTRIKGDSFGKAKAGLSVFTIKSKSKVVPVSIISKYKLFSKVIVYIG
                     EPISFEEHFKEKLSNDDHERISQEILEVIKQNYFKYSK"
     gene            3329..4168
                     /locus_tag="KRO40_001258"
     CDS             3329..4168
                     /locus_tag="KRO40_001258"
                     /EC_number="1.17.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="HBH2092080.1"
                     /translation="MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQ
                     AVAKYEEKGLKTVNEIDTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKI
                     HTVVSEYHNKGYEIIVIGDMKHPEVIGINGWCENSAIIIKTLEQMENMEFDNSKRYCL
                     VAQTTINPELYISIVNKLSDKLEEIVFNDTICSATKTRQESAKELAKEVDCMIVIGGK
                     HSSNTQKLVKVCEDLVPTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFL
                     ENL"
     gene            4413..5567
                     /locus_tag="KRO40_001259"
     CDS             4413..5567
                     /locus_tag="KRO40_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenic efflux protein"
                     /protein_id="HBH2092081.1"
                     /translation="MEMLISASEEAFLHVGSMIGFFILLFGYINYKTSGNFTNIISKN
                     RKFQPLIGALIGAIPGCGGSLAIMPLYINGKLSFGAIIASLIASMGDAAFVLISSNIK
                     MYFFVTIVSTITGIITGQLVDYFKLEEKLGLKNRRKSDKYDISKNNPKENKEQHNHDE
                     IILDTLAKSHGNTNRLAFIITHGKGYKIYIGIIVIGFIFMSLAHSGLNLPIIEKLHSL
                     EEVIAVIGILFSIIYMWCFKKVFKNSNQKEEENKKISLREMLIHSVGEISFVITWIFI
                     AYLIYDLIILILGGDEYLVKLVLSTGVISVFIGAGLGLIPGCGIQIVLMSFYLKGTIP
                     LGAVIANSISQDGDALFPLLAMDKKSSLWAMIITTIPAILVGMIVYAFLG"
     gene            5873..7570
                     /gene="ade"
                     /locus_tag="KRO40_001260"
     CDS             5873..7570
                     /gene="ade"
                     /locus_tag="KRO40_001260"
                     /EC_number="3.5.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine deaminase"
                     /protein_id="HBH2092082.1"
                     /translation="MGNLKRQCDVSSGREKADIVLKNGTIINVFTEELITGDVAIVGD
                     TIVGIGDYKGNVEIDCSNKYISPGFIDAHMHIESTMVMPIELSKKLLKSGTTTIIADP
                     HELVNVKGVSAIDFLLESTKDIPLNVYIMVPSSVPATSFETNGVGKFSAKDMESYVNN
                     PRILGLGEVMCFNDVINSENEILDKLELFKNKVVDGHAPNINGKSLQTYVCAGIENDH
                     ECITFDEVYEKLRAGLKILIREGSAAKNLKSIVSGMLKHNLPIEEFMFCTDDKHLDDI
                     EKQGHIRWNIKCAIDLGMEPVRAIKVATYNSAKAYGLRKIGAIGAGYKADIVVLNDLD
                     KMEVDSVYKDGNLVNEEMFSNYNYEIKDKELLNTVKFKYINKEKIQLKVSEKNYVMEI
                     VPYQILTNKVYESLPCADGYFVPNKEYSKLCVVERHRMTGNVAIAPLKGFGIKNGAIA
                     TTVAHDSHNIIVAGDNDDDILVAINYLKEIQGGYVIVSNGKVLAHLSLQVAGLISTFT
                     AEEVQEITDNMLEIARKMEVPEYVDPFITLSFMALPVVPQIRLTDLGLFDVEEFKFI"
     gene            7922..8386
                     /gene="bcp"
                     /locus_tag="KRO40_001261"
     CDS             7922..8386
                     /gene="bcp"
                     /locus_tag="KRO40_001261"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002586316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-dependent thiol peroxidase"
                     /protein_id="HBH2092083.1"
                     /translation="MLSIGTKAPEFTLEDKDGNKVSMSDFKGKKVVVYFYPKDNTPGC
                     TRQACAFRNAYDGFKKEDIQVIGISKDSIKSHQKFAEKHELPFILLSDPDLVAIKAFD
                     VWKEKKMYGKTALGVVRATYIIDENGIIEKVFEKAKPDTNAQEILEYLEKQE"
     gene            8396..9139
                     /gene="yaaA"
                     /locus_tag="KRO40_001262"
     CDS             8396..9139
                     /gene="yaaA"
                     /locus_tag="KRO40_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HBH2092084.1"
                     /translation="MIIMLSPAKNMKNIEVFDRDLSLPCFIDNTKEIVENIKTFGIED
                     FKNKMKINEKLAVLNKNRFESIKFDRLGNPAILTYDGIQYKNIEAENFTRKDEEFANS
                     CIRIISGLYGVVKPYDSIYEYRLEMQTKLQVGEFKNLYEYWGNRIYKELIKEKTAIVN
                     LSSNEYSKSIEKFIKDSDTYITCTFKVNKNGILKVESTQAKKARGMMTKYIVKNRIRD
                     IEELKKFDLEGYKYKENLSNNSEYIFVKE"
     gene            9267..11924
                     /locus_tag="KRO40_001263"
     CDS             9267..11924
                     /locus_tag="KRO40_001263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBH2092085.1"
                     /translation="MENHKQMPWHSRATHEILESLDSSEEGLTDTEAEKRLKENGLNE
                     LRKKPPRTTLQMLWSQITDAMVMILIGAAILSLIFGEFTEAFVILIIVTVNAVIGIVQ
                     EKKAESSLEALKNMNSPTARVMRDGEENVIPASNLVVGDIVFLEDGAMVPADLRLIET
                     SSLKIQEASLTGESVPSEKDADTILPKECVLGDRSNMAYTSSIVTYGRGVGVVVATGM
                     DTEVGNIAHLLDSQDDFDTPIKRKLNTVGKTLSVIGIIVCVVIFAIGAFYQRPLLPMF
                     MIAISLAISIIPEGLPATATIVMALGVQRMAKRNALIRKLPAVETLGGATVICCDKTG
                     TLTLNKMTVTHIAVNGDFESGKVTSIDTASEKHPLVYKEIVYAGALCNDACINPDKTD
                     EILGDPTEGALIFMAKKFGIDQEALEEEYPRVFEQPFDSDRKCMTTVHNIDEKIIAYT
                     KGAVDEILDLCTKILTSKGERNITEVDKKNIHELCLNMSKDALRVLGFAKREISSIPK
                     EDSENIEYDLTFIGMVGMIDPPRTEVIDAVSTCKEAGIRTIMITGDHKVTATTIAHEL
                     GIWSEENTVISGDELDNLSDDELDEAVKNTTVFARVSPFDKLRIIQSLKRIGEVPAMT
                     GDGVNDSPALKSADIGIAMGISGTDVAKDSSDMILMDDSFTTIAYAIKEGRRVYRNIQ
                     KVIQFLLVGNIAEILTLFVAILLNWDTPLLAVHILWVNLATATLPALALGVDPPSRNI
                     MKHQPVKSTTLFEKNLIQRVVTQGVFVAIMTILAYKIGLNIENHSVGQTMAFCVLAFS
                     QMLRAFSQRSNTDSMFNRNNGKNPFLLISFLTSAFLIAVILFVPVFRNAFNLTVLNNL
                     EWLITIVLAIMSVIQVEVGKIIKRKKLKK"
     regulatory      11978..12080
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            12190..13455
                     /locus_tag="KRO40_001264"
     CDS             12190..13455
                     /locus_tag="KRO40_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
                     /protein_id="HBH2092086.1"
                     /translation="MYNKETICVQGNYKPGNGEPRVLPLYQSTTFKYSSIDQLAELFD
                     LKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILC
                     SSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEV
                     IDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGII
                     VDGGNFNWDNGKFPELVEPDPTYHGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNA
                     YLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRG
                     CSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIAS
                     GVLPSLIRLSVGIENVEDLIADLNQALNF"
     gene            13485..14375
                     /gene="metA"
                     /locus_tag="KRO40_001265"
     CDS             13485..14375
                     /gene="metA"
                     /locus_tag="KRO40_001265"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HBH2092087.1"
                     /translation="MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAI
                     LNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRESKRSCNEYVKEFYKTFDEAKGE
                     YFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVK
                     KLPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSK
                     EAGPYIITNSRDVFVMGHSEYDKYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTV
                     KWKKHSELLFRNWIKNYLIQ"
     gene            14866..15309
                     /locus_tag="KRO40_001266"
     CDS             14866..15309
                     /locus_tag="KRO40_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2092088.1"
                     /translation="MDEMSFKKELLELTRDINMKFTTLLSDFYQPLGITAVQALILSE
                     LCEHGEKKISDLGKNLNMTNSNVSVICQRLEKNGFLNRIRDIEDQRIVKVKVTNKSLD
                     IQEHISSSIFDSYFENMTSEKLQDMEDIIEGLEKLNKLLTYIDCK"
     gene            15340..17157
                     /gene="ftsH"
                     /locus_tag="KRO40_001267"
     CDS             15340..17157
                     /gene="ftsH"
                     /locus_tag="KRO40_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBH2092089.1"
                     /translation="MDEHKPQKRSALYYYTVIIIVVMFLNALIFPSLMDKKMVEIDYG
                     KFLTMLDTGKVKSVEIENNRIAINPSSSKDKNIYITGRMDDPELVDRLKNAKVEFTKV
                     IPKENSPLLSILLTWIIPIGILMLFGNLMMKSMQKRMGGNAMQFGKSNAKMYVSAQSG
                     KRFNDVAGQDEAKEALTEIVDFLHNPEKYKKIGAQMPKGALLVGPPGTGKTLLAKAVA
                     GEANVPFFSISGSEFVEMFVGMGASRIRDLFKQAKEKAPCIVFIDEIDTIGKKRDNGS
                     GLGGNDEREQTLNQLLSEMDGFDGGIGVVILAATNRPDSLDKALLRPGRFDRRIPVEL
                     PDLGGREAILKVHAQNVNVSSDIDYNAIARSTSGASGAELANIVNEAALLAVKSGRDI
                     VEQQDFEESVETVIAGYQRKGAVISDKEKKIIAYHEIGHALVAAMQKHSAPVHKITII
                     PRTSGALGYTMQVAEDESVLMSKEEAIDKITTFTGGRAAEEVIFNTCTSGASNDIEQA
                     TKIARAMVTRLGMSEEFDMVALETVSNQYLGGDTSLACSSDTAAKIDEEVFKIVKACH
                     KNAIEILENNIDKLHELANYLLEKETITGDEFMEILNLN"
     gene            17335..20037
                     /locus_tag="KRO40_001268"
     CDS             17335..20037
                     /locus_tag="KRO40_001268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase KdpD"
                     /protein_id="HBH2092090.1"
                     /translation="MDRPNPDILLEKIKNEEEKLSRGQLKIFFGYAAGVGKTYSMLES
                     AQNLKKVGVDVVVGYIEPHTRPETLALLDGLEILPVKDIEYKSIKLKEFDLDAALARK
                     PEVILVDEFAHSNVAGLRHTKRWQDIEELLLAGINVYTTVNVQHLESLNDIVEIITNV
                     SVKETIPDKFLDTNTQLELIDVEPDVLLERFNEGKIYKKEQATRAKNNFFIKDNLVAL
                     REIALRKTAERVNKEVQMTRLSKGDVTVIPTSDTLLACISPSPSSAKVIRTASRISDS
                     TFAKWIALYVETPNTARLPFDEQKQLQNNLKLAKKLGGEIIVLHGENIIEQILRIAKL
                     RNVTKIVIGRNHSSNKRFSKRFKKDIVDKLIDEVDYIDIHIIPYKFASDVKYKPKKDK
                     SSIKSKFKISKVDFIKLIFITLMISILAYAVQSMGFIRENILLIYMLGVVLVSMWTKG
                     YSTGIISSVFNIVLLNYFFTAPLYTLSIADSNYIVTLVVFSIVGIITSTLTSKIQHEA
                     ETAAKREENTKMIYQIIKGFLRLSNKDDIVNKGIELLSLSLSRDVICYLNVDKHNKSK
                     LYKKNTNNKDKNDLDSEDEKAVASWVLSNSTVAGNDTDTLPGSKGYYIPIVGMNLTLG
                     VVGISCIDSKLDTEDISLIETIIAQMAIALDREILSEAKENTNLEIERERLRSNLLRA
                     VSHDLRTPLAGISGAVSTIIKNKGTIGQDIIDELLSGVYEDTQWLIRLVENLLSMTKI
                     DEGKLEVKKHSELVEEIISEALQKIKKRIENALIDINIPEQILFVPMDAKLIEQVLIN
                     LIDNSLKYSKEDCKIEINVYEKDDYVWFEVSDNGPGISKELKKHIFDRFFTGEEGAKD
                     SRKGVGLGLSICKSIIQAHKGEIMVENNKDKGSTFKFSLPKENE"
     gene            20071..20769
                     /locus_tag="KRO40_001269"
     CDS             20071..20769
                     /locus_tag="KRO40_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092091.1"
                     /translation="MSKKLILLVEDDKTIRKFISTALLTQDYDVKEAITGKEGISIAV
                     SYSPDVVLLDLGLEDMDGIEVIKAIRQFSNIPIIVVSAREQDRDKVEVFDAGADDYLT
                     KPFSIVELLARVRVAFRHSQVEAQQKDDVKSTFEVDKLLIDFDKRKVIVDDVEVHLTP
                     IEYNILSLLAKHHGKVLTHNFIIKEIWGSVIGNETKSLRVFMATLRRKIEKQPANPRY
                     IITEVGVGYRLNDE"
     gene            21126..22082
                     /locus_tag="KRO40_001270"
     CDS             21126..22082
                     /locus_tag="KRO40_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CorA family divalent cation transporter"
                     /protein_id="HBH2092092.1"
                     /translation="MYILNLNTRETIEDFRDKFYVAENSYLILSAPKNLKLLKETLDI
                     DEITFNDCLKFDEITKLDLFDNYDFLSLNTFELRDGEAVIEEVNMYLSDNFILVVVNE
                     EHFLFEFVKNIILKNSQLEKNPVINLFKINYLILREVIKNGFESLEKVEELILQIEDE
                     MMDNINKNHVSRISDVRGLTRIIVKNTRPLLYIGDRIVKENIRYLKYSNVKKYNLENF
                     QGIDFGIDKLYNFALSTRELADKLLDIYSSRVGEKTNNLITKLTLLTAISAPLTIITG
                     IYGMNFRYMPELNWIYGYPATLFFMLCIIFVGIIIFKIKKLL"
     gene            22259..22414
                     /locus_tag="KRO40_001271"
     CDS             22259..22414
                     /locus_tag="KRO40_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092093.1"
                     /translation="MKGILKELTAKLYSFFYFMFWGFYFSAGYFFYKNICTSFLVRPY
                     FSDFEHK"
     gene            22544..23557
                     /gene="aroF"
                     /locus_tag="KRO40_001272"
     CDS             22544..23557
                     /gene="aroF"
                     /locus_tag="KRO40_001272"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBH2092094.1"
                     /translation="MIVVLKMGADKNEVKKLIEAIGREGVEVNPIDGTELTVLGLVGD
                     TSKIDAKRIEANKVVEKVMHVVEPFKKANRKFHPEPSIINVNGMEIGSKKIAMIAGPC
                     SVETEDQIVSIAKDVKKSGAGFLRGGAFKPRTSPYAFQGLKYDGLDLLKKAKEKTGLP
                     IVTEIMSTQDIDIFEENVDVIQVGARNMQNFDLLKELGKTNKTILLKRGLSATIEEWL
                     MSAEYIMAGGNENVVLCERGIRTFETYTRNTLDLSAILAVKKLSHLPVIVDPSHAAGK
                     SWMVDSLSKAAIAVGADGLIIEVHNDPAHALCDGKQSIKPNEYDELISELKTIASAVG
                     REI"
     gene            23579..24643
                     /locus_tag="KRO40_001273"
     CDS             23579..24643
                     /locus_tag="KRO40_001273"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HBH2092095.1"
                     /translation="MEEKLLVNLKENSYNIFIKKNILKNIGEEIKKIYFGNKIFIVTD
                     ENIAKLYLDKVKNNLSESGFEIKSLILKSGEETKSFNTLPKIYDSLLDFKLTRKDLII
                     TLGGGVIGDLGGFAAATFLRGISFIQIPTSLLAQVDSSVGGKVGVDLERGKNLVGSFY
                     QPKAVFIDPNVLLSLPEKFYRDGMAEVIKYGCIKDKTFFDKLLSLKNREEVMQHIEYI
                     IHKCCFIKKTVVEADEKDFGDRMLLNFGHTLGHAIEKYYNFTGYTHGEAVAIGMYKIT
                     LESEKIGITKKGTSELIKSILMNYNLPYEIELRDNKSIVDAISLDKKNLGDTLKIILL
                     KDIGESIIYNTTSKFFQEVR"
     gene            24643..25956
                     /gene="aroA"
                     /locus_tag="KRO40_001274"
     CDS             24643..25956
                     /gene="aroA"
                     /locus_tag="KRO40_001274"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HBH2092096.1"
                     /translation="MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNID
                     FSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEGILNRENQLNQPKLTIDCNESGS
                     TLRFLVPISLAFDGIKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKL
                     KPDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEI
                     INNNYKEFIIKGNQTYKARDYKVEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSE
                     VVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLSVVASLSIGRTTIIN
                     AGRLRIKECDRLHAINVELSKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMT
                     LAIASCRCDKPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK"
     gene            25934..27013
                     /gene="aroC"
                     /locus_tag="KRO40_001275"
     CDS             25934..27013
                     /gene="aroC"
                     /locus_tag="KRO40_001275"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HBH2092097.1"
                     /translation="MSGIWGNNLKVSIFGESHGNAIGINIDGLPSGIELDLDNIDKEM
                     KRRAPGKNSISTSRNESDIPEILSGYFNGRTTGTPLCAIIRNSDTRSKDYGELKNLMR
                     PGHADFTGNVRYSGFNDYRGGGHFSGRITAPLVFCGAICKQILSQKGIEIGAHIKKIK
                     NIEDMSFDYVNISKQQLSNLQTLELPLLDLSKEEAMKNTIIDAKNQGDSVGGIIECAV
                     VGINVGLGNPFFDSVESTLSHLLFSVPAVKGVEFGLGFELADMYGSQSNDEMYYEGNQ
                     VKSKTNNNGGIIGGITTGMPIIFKVAIKPTPSISRQQNTVNIKDKKDDILYIKGRHDP
                     CIVQRAIPVIEAVTAIGIFDLMKGR"
     gene            27016..28212
                     /gene="pheA"
                     /locus_tag="KRO40_001276"
     CDS             27016..28212
                     /gene="pheA"
                     /locus_tag="KRO40_001276"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HBH2092098.1"
                     /translation="MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTIL
                     QKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEISRGLQKRLIDNDGEQKIEFSLDS
                     SNKKFDLSNVNRYKSLKDELNKKNILVGFSGKSGSFTEEALNKFFNKKISKKQFKEFE
                     DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDT
                     KLEDIKEIYSHPQGIGQCSEFLKQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKK
                     AASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVFSVEHEAGKLYKVLG
                     YFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNSKVYDLLELIEHNTAYFKFMGV
                     YKNKTE"
     gene            28259..29068
                     /gene="aroE"
                     /locus_tag="KRO40_001277"
     CDS             28259..29068
                     /gene="aroE"
                     /locus_tag="KRO40_001277"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBH2092099.1"
                     /translation="MNFFGLVGEKLSHSVSPQIHKRVFEILNIESAYKNFEISKEDIS
                     KLDGAIKLLGIQGVNVTVPYKERIMKYLDFISPEAKRIGAVNTILLRENMLYGYNTDY
                     FGLDSMFKMANIDVQGKVAVILGTGGASKAALTYFIDSGIEKLYVSTRKKDDKKLLNS
                     KAILIDYEELKHIKGDIILNATPVGMYPNVGISPVSKSIIQNFDILIDLIYNPGETEF
                     LRIGNSMGKKTCDGLYMLVGQAIKSQEIWQDTKIDNSILDVIYNELKLEFL"
     gene            29080..29613
                     /locus_tag="KRO40_001278"
     CDS             29080..29613
                     /locus_tag="KRO40_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HBH2092100.1"
                     /translation="MINKTKEKLILIGMPGSGKTTIGKLLAKEYNCSFCDMDDYIIQI
                     SQKSIAELFSEGEDIFRNYETQACRELSISDKTVISTGGGVIKKDVNMEILKETGIII
                     FIDRPIQKILEDININSRPLLKNGKDRLYNLYNERINLYKKFSDIEILNDKSLNNAVY
                     NITNAVSENFKFDFKEK"
     gene            29634..30473
                     /locus_tag="KRO40_001279"
     CDS             29634..30473
                     /locus_tag="KRO40_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HBH2092101.1"
                     /translation="MNIVIVGLGVIGGSFAKALKKAGYENVFGVDVDLETLKKAEKSK
                     IIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNFFKKGTIITDTTGIKETLIND
                     VLQIIPDDIDFIFGHPMAGREKKGIDFASEQVFNGANYIITPTGRNNIKNLELVENLI
                     LEIGFKRVKKLTSQKHDEIIAFTSQLPHVMAVALINSDEEGRDTGKFIGDSYRDLTRI
                     ANMNEDLWSELFLGNRDNLLKVIENFESEVNLVKEAIFNNDKNKLIEYFKKSSIRREA
                     LEK"
     gene            30741..32222
                     /locus_tag="KRO40_001280"
     CDS             30741..32222
                     /locus_tag="KRO40_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH2092102.1"
                     /translation="MKKNRLIAKNISIAFIVLFFFSVFTFFYVGNINRVLEYETNDII
                     TVTIAGWIILSFLFLGIIIYILYSKANSQKTIEKVAYTDFVTGYSNWRKFELDVTNLL
                     KKTSQNNKYAMVIFDIDKFKAINDIYGHKKGNLILKDIADTLNELTNINETFARVSAD
                     SFNILLTYNKKEDIINIIKKIMANNELVNLSFGIYEIKDKDLSVSVYSDRASLAKSSI
                     KNNSDVNFAFFNDKLREKLLLEDKIEKEMEYALESGQFVMYLQPKYNIKLDKFCGSEA
                     LVRWQYTEKEVIYPGDFIPIFEKNGFIRKIDMYILEQACKEIRSLFDKGISPLPISVN
                     FSRVDFFKKDFIENIVNICDRYKIPYSLIEIEITESSMFGDTDTLFNVSRNLQDIGFI
                     VAMDDFGSGYSSVNMLKNIPLNVIKLDRGFFVDDKDVDKSQIVIKSIVSLIKQLGIRV
                     VAEGIETRSQIEMLKKANCDIVQGYYFSKPLPIKEFEKLVYKI"
     gene            32255..35692
                     /locus_tag="KRO40_001281"
     CDS             32255..35692
                     /locus_tag="KRO40_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBH2092103.1"
                     /translation="MIRAKSLKNVLSIVLIFLFTIISFSDFAFKTNVQEEENSKINLR
                     EISLQSSNAIKIKLDSSLSFIKSVANMVSYFNTIDNSKIVPLLANISKESDFQRISIV
                     SPDGISHTSDGKIINVSKYQYFKKAIKGESNISEVVKSPIDGKDTFVIATPVFNKNNK
                     IIGVLYGSYYNDKLAEFIDITSFNSEGYIDIFESSGQFVLKSSHTNKLIKSSSNIYDI
                     FKKASFDDGYSYKKIYEDTKNNKSGFTSYEYKGENRYATYTPIGVNDWYVISVIPQYT
                     VRRNIDKINQLAFSLIFKVFLLFIMLIIYIIYKNNKSQKDILKANKEISSITNSIPGG
                     VQKCTLGETCNINFLSDGFIELFGYTREEIKTLFNNDFYSLIHKDDVERIKKEIFKQL
                     YKNKTIELEYRIITKNGNTVWVLDKGELITEPDGKEYFCCVTVDITRTKQLEQEMEQK
                     NLELEMISENVLGGIIITEFNDDFTIKYANSGYLSMIGYTREQLENELKYKACNLVFY
                     EDKKKALESIQHQLNTKGIAVYQHRIRRRNGNIIWVSIKGRLIVDDDGIEKGIWILND
                     ITDLKNAEQKLKINEERFRIALKQTSNTIFEYDIKTKSLLNTSKELDKYNIYKITKNV
                     PYSLVESGVIHKDFSDDFINMYENVINGAKKASCVVKMKLPDENYIWNKVTLTTIFDE
                     DGNPVRAIGIQEDISKQKEAEIRYNQEGKYHSAILSEAMITYEINVSKDTFIKGNESW
                     QKPFGIKPDNNYSQMVKTIANSIVHKDNKETFLNTFLCENLLDAYKNNVTEIKLEYRR
                     MNQENKMIWVICTMHLIKDSITNDIKALAYVKDIDKQKNEEIRLKLKAERDTLTGLYN
                     KGTTEKLINDFLNSEEASLGMHAFLIVDIDNFKSVNDNLGHVFGDKVLFEVSKNLKPI
                     FRKDDIVGRIGGDEFIVFLKNIQSFENIKKKAEKICDIFRNSYTENKKTYKISGTVGI
                     SFVPEHGTVFEELYKKADIALYYAKSKGKDKYALYNDCIYQNELENNISDNNIKLADK
                     CEKSKPVLKEILDSIDNYIYIVNPNTYELLFINNKVSRLDLEIKLGETCYKSLLKSDR
                     PCNNCPLNGLEENKHSKFKIETNTFGKNISIASWINCIDGEYNCLIECIDSSLYKNK"
     gene            35710..36456
                     /locus_tag="KRO40_001282"
     CDS             35710..36456
                     /locus_tag="KRO40_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcF family protein"
                     /protein_id="HBH2092104.1"
                     /translation="MLNSITLILGIIFTIYYFYLKIVFGGISFSEIFLVVGIVLIIYQ
                     IFKKKIKEKKVFYRVLKIIISIFLIVFVVTESLIIFYPKNSLESKSDYLLILGASVKK
                     TTPSTTLKGRLDTALKYLKINDNCYVVVSGGKGSGEKITEAKAMKDYLIKNGIDKNRI
                     IEEDKSTNTYENFKYSKLKIEEHSQGKLSDLKVKIVTTDFHVLRSKILAYRNGYKNTS
                     FYASKSKLSFVPTYYTREFFALWKTIIFDR"
     gene            complement(36405..36713)
                     /locus_tag="KRO40_001283"
     CDS             complement(36405..36713)
                     /locus_tag="KRO40_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH2092105.1"
                     /translation="MNFFKENSTFYFATVEDNKPRVRPFGFIMDYEGKLYFGIVKYKT
                     SYKQLLVNPNVEISTTSKVGKWIRIKGIEKTRYEFISSLFIYYLSKMIVFHNAKNSLV
                     "
     gene            37517..41659
                     /locus_tag="KRO40_001284"
     CDS             37517..41659
                     /locus_tag="KRO40_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF11 domain-containing protein"
                     /protein_id="HBH2092106.1"
                     /translation="MATVSGQIVFDRNRSATIDSGDSGIANIPVVLQDIATGVRLVVL
                     TDASGNYVFTNVPNGNYRIVEAFGTTGGVPTPGNFATAIVGPVPIAEMPPISSVTSPP
                     IGSTNLDGTTPNTLLITVAGSDITNQNILNGPVIYTPIENILDSCVSVSNINLITDAD
                     NGTFGFFPPGTPSNTGPEIEPYPNVTPDFTYVVPDPTKFTPLDGEYTVQNIMTNAMSN
                     VIGAWWRIADHTTGNETGRMMVVNGFNPGAVFFKSTVQVTPNTNYLFSTWILNLFKVT
                     GYPPPQLGVRIFDQNNNILYQATLGAQIPVNTNAPEWKEVGTVINSQNNNQLTVEFFS
                     EGESAIGNDYAIDDVSLREIAVPTFTPIKTSNTETANVGDIITYTVTLDNTCDSPLTN
                     VFFRDLIPNGLEFIPGTVTVDGVSVPGVDPNTGFPLPDIGGGTGVEVTFDVVVESIPN
                     PNPTNNIATIDYSYTPVEGGIPNDFSVDSNPVPVEVISADIEVTKLSEPTIVNPGEEL
                     IYTIKVVNNGPFPSENVVLTDDVPASIVNPEYSLDGGVTFQPWTGSLNIGTLEVGETR
                     VIIIRGIVNPSTVGIITNTAVVSSTTADPNLNNNTSTIETEVNLLADILVMKTAEPNS
                     AVPGTLLRYTIQVENLGPANAENVILNDDIPASIINPEYSLDGGASFQPWNGSLNIGT
                     LNSGISLTVLIQGTVSLNSSEYIVNTATVSSTTPDPDLSNNISTIITPVNPQAGISII
                     KVADEDVAVPGEEFVYTIEIFNEGPSNATNVVLTDDIPDVILNPEYSLDGGATFQPWT
                     GSLNIGTVAPGQLIRIIIKGLVSSTATGDITNTAEVSADVPEPVTDSSTVTTPIVPSA
                     DIEVIKTSNMDTAVPGETFSYTITVTNLGPSAAQSIVLTDDIPDVILNPEYSLDGGVT
                     FQPWNGNLSIGTLDAGEIRSIIIRGTVSQTAVGTIINTATISSPTPDPNPDNNTSTDE
                     TDISPLADISVIKGNEPVAIPGGRFIYGIEIANAGPSFTENVTLTDNIPASILNPEYS
                     IDNGVTFQPWNGSLNIGTLDAGEIRNIIIRGTVSQTAIGTIINTATVSSTTPDPNLNN
                     NTSTSEAEVSSSADISVVKRSNQIVVVPGDVLDYTIEVRNAGPSTTQNVTLTDNIPAS
                     ILSPEYSIDNGVTFQPWNGSLSIGTLDAGEIRNIIIRGIVSQTAIGTIINTATVSSTT
                     PDPNPDNNTSTSEIDISSSADISVIKLANKTEACVGEQIDFVIVVSNAGPENAQNVTL
                     IDNVSDKLKKAVFSLDRGVSFQPWTGSLNIGTLPAGTLRVILLRGIIKSTCLDRLTNI
                     AEITSTTPDSNLNNNISRVQVEIKQCCCNDCCCNNCSNCCCNDCGCKDCCCNCCKNDF
                     WC"
BASE COUNT        16832 a         4565 c         7268 g        13193 t
ORIGIN      
        1 ttgagaagtg ataatttata tttaataaaa aataggcata tattaggagg acatatggga
       61 aatacttttt atatagtaag acatggacaa acggattgga atatattggg aaaaacacaa
      121 ggtcatggta attctgacct tacgcctcaa ggtatagaac aggcaaaaga actttctgaa
      181 gatattggca agtattcaat tgattatatt tttagtagcg accttgggag agcaatgcaa
      241 acagctcaaa ttttaggaga taagctcaat attgaagttc aaaaaactga ggcacttaga
      301 gaaatgggat tcggagtttg ggaaggcctt ttaataaaag aaattcaaaa agattattca
      361 gatatatatg caacatggag aaatgaacca cacttagtaa atataccaga aggcgaaact
      421 cttaagatta taaaggaaag agtagatgct tttataaagg aactaaatga aaaatatgat
      481 aataaaaata taattcttgt tacacattca attacattga gggttatgtt gttgtcattt
      541 ttagaatcag gtatggaaaa tatatataga attaagcaag ataatactgc tttaaatata
      601 gtagaattta aagattatgg gcctgttata gtaaaaatga atgatacaag tcatataaaa
      661 aatcatgtaa agataaataa ttctgcactg gagtaggaat caattataag gagaaattta
      721 tgagtaaagt tatagtagtt ggtggaggag cttctggaat gatggcagct ttgtcagctt
      781 caaaaaacaa taatgaagta atattagttg agagaaatgg agaattagga agaaaactta
      841 gggcaactgg tggcggtaga tgcaatttta ccaataatag agagatagaa gatttttttg
      901 ataaagttgt cagtaataaa aaatttctct atagtagttt ttatacattt acaaataaag
      961 accttatttc gtattttgaa agtagaaatt tggaatataa gattgaagaa gaaaatgacc
     1021 acaaagtata cactaaaaat gataaatcta tagaagtaat agaagtatta aataaagatt
     1081 tactcaatca caatgtaaag ataatgtata ataagaaagt tatagatatt ataactgaag
     1141 aaattgctct aaaagatgat tctaataagg acaagtcaaa gtatctaata aaagggatta
     1201 ttttagataa tggagataaa atactaggag acaaggttat tatatcaact ggaggagtga
     1261 gttattcaaa gacgggttca gatggttcaa tgtataagat tcttaaaaag catggacata
     1321 cattaaacaa actatatcct gctttagttc cacttacaat agaggaaaaa tggattaaag
     1381 atttacaagg aatatccatg aagaatgtgg aaatatcttg taagattaag aaaaggaaaa
     1441 tatcaaaatc tggagacatg ctatttgccc attttgggat aacaggacct tgtgttctta
     1501 taatgtcttc ttatattaac aagattattg aaaaggaaaa ggtagaatta aatatagatt
     1561 tcttaccaaa tttaagtact gatgaaatct ctagtataat cagagcattt ccaaataaaa
     1621 atgttctaaa taatcttaag caaatactac ctcaaaattt cttaaaagag attttttctc
     1681 tattatcttt agttgataaa aaggcaagtg atttgtctaa ggcagatgaa attagaatta
     1741 ttgagtatat aaaaaatatg aagctaactt gtaatgggac tacaggtata aacactggta
     1801 tggttacttc tggtggtatt tcagttaaag aaattaattc ttctactatg gaatctaaat
     1861 tagttaagaa cttatttttt acaggtgaag taattgatat agatgcagaa actggtggat
     1921 ataatttaca aatagcattt tcaactggat atcttgcggg tataagtgta taaatataat
     1981 tttttaataa ttaaatatga ataaatagag gtgtatatat gggtaattta gttatagctg
     2041 tagatggtcc agcaggagct ggaaaaagta caatagccaa gatagtagca aaaaagctaa
     2101 atataaatta tatagataca ggtgctatgt acagagcagt tacttataag tgtttaaaaa
     2161 gtggtattga tgtcaataat gaaaaagaag ttattcaaat agctgaaaat tcggatatag
     2221 attttaaaga taacaatata tatttggaca aagaagttat aaatgaagaa ataagaacaa
     2281 tagaagtaag caataatgtt tctaatgtag caaaaataaa agaagtaaga cagttgatgg
     2341 ttgaagttca acgaaaaata ggaatgaaaa attcagtaat actagatggt agagatatag
     2401 gttcatatgt tttcccagat gcagattaca aattcttttt agtagctact ccagaagaaa
     2461 gaggaaatag acgctataaa gaactttgta ataaaggata taatactact ttagaagaag
     2521 taattgagga tataataaga cgagatgaaa ttgattcaaa tagagaattt gcaccattgg
     2581 taaaagctaa tgatgcacta gaaatagata ctacaggaaa aactatagaa gaagttgtag
     2641 aagaagttgt atctaaaata aatctttagt tttttatgca tcataatgaa aataaatgta
     2701 gtgttgaagg gagataaacg tgaattttta tagatttgta ataaatattt ttaagggttt
     2761 ttctaaaata ttttttaaat atgaagttat aggtgcagag aatattccag atagaggaaa
     2821 tatagtaata gcatcaaatc ataaatcgaa tcttgaccct atattcttgg ctgctgccat
     2881 agaaaataga gaaatagctg caattgcaaa gaaagaattg tttaaagtaa aaccattggg
     2941 atttatatta aaaaaattgc atgttatgcc tataaataga gaaaaaccag atgtatctac
     3001 aataaaaact attttaaggt cagttagaga cggttatgta ttaggaatat ttccagaggg
     3061 tactagaata aaaggagatt cttttggtaa ggctaaggca ggtctttctg tatttacaat
     3121 aaaaagtaaa tctaaagttg ttccagtatc aataatatct aaatataaac tttttagtaa
     3181 agtaattgta tatattggag aaccaatatc atttgaagaa cattttaagg aaaaattgag
     3241 taatgatgac catgaaagga tatcacaaga gattttagaa gtgataaaac aaaattactt
     3301 taaatattca aaataagggg gtaaagttat gaacataaaa atagcaaaaa atgctggctt
     3361 ttgttttgga gtaaaaagag caatgaaaat ggcatgggat gaagttgaaa aaaatgattc
     3421 tggcatatat gctttaggtc ctcttattca taacaagcaa gcagtagcaa aatatgaaga
     3481 aaaaggtctt aagactgtga atgaaattga tacaatacca aatcatgaaa atatgataat
     3541 aaggtctcat ggagttcctg aaaatatata taaggaagcc aaagataaaa aattaaaaat
     3601 tgtggatact acatgtccat ttgtaaagaa aatacataca gtagtaagtg aatatcataa
     3661 taaaggctat gaaataatag ttattggaga tatgaagcat ccagaagtta taggtataaa
     3721 tggatggtgt gaaaattcag ctataataat aaagacctta gaacaaatgg aaaatatgga
     3781 atttgataac tccaaaagat attgtcttgt tgcacagact acaataaatc cagagttgta
     3841 tataagtata gttaataaac tatcagataa attagaagaa atagtattta atgatacaat
     3901 ttgttcagct acaaaaacaa gacaagaatc agctaaagag ttagctaaag aagttgattg
     3961 tatgatagtt ataggaggta aacacagttc aaatactcaa aagttagtaa aggtttgtga
     4021 agacttagta ccaacttttg caatagagac taaagatgaa ttggatgtaa atacgcttaa
     4081 aaaatataaa aatttgggta ttacagcagg ggcatctaca cctaattgga taatagaaga
     4141 agttgtaaca ttccttgaaa atttataatt tgataggtaa taaaaatagg tggacattgt
     4201 tataatttat cataatatcc acctttgatt tcatattaca tgtggtaaat agataaccta
     4261 atatcaaaaa gtgtgtatct taagatgaaa aactaagagt ataagatgcg cactttttaa
     4321 tattagaaat tcaaaagaaa tattgatatt gattatcaat agaaaataga atataatata
     4381 attgttgcaa aattagtcta ggaggtaaat taatggaaat gttgatatcc gcttctgaag
     4441 aggcgttttt acatgtaggt tctatgattg gattttttat tttgttattt ggatatatta
     4501 attataaaac tagtggaaat tttactaata tcatatcaaa aaacagaaaa tttcaaccct
     4561 taataggtgc tttaattgga gctataccag gttgtggcgg aagtttggca ataatgccat
     4621 tgtatataaa tggaaaatta agctttggag caataattgc aagtttaata gctagtatgg
     4681 gagatgcagc atttgtactt atttcatcaa atattaaaat gtattttttt gtcactatag
     4741 ttagtacaat tacaggaata ataactggac aattagtgga ttactttaaa ctagaagaaa
     4801 aattagggtt aaaaaaccgt agaaaatcag ataaatatga tataagtaaa aataacccta
     4861 aagaaaataa agaacaacat aatcatgatg aaataatttt agacactcta gctaaatctc
     4921 atggaaatac aaatagactt gcatttataa taacacatgg aaagggatat aaaatttata
     4981 taggaattat agtaatcggt tttatattta tgtcacttgc tcactctgga cttaatcttc
     5041 ctataattga gaagttacat tcattggaag aagtaatagc agtgattgga atattatttt
     5101 caataattta tatgtggtgt tttaaaaagg tatttaaaaa ttctaatcaa aaagaggaag
     5161 aaaataaaaa gatttctttg cgagaaatgc ttatccattc tgttggagaa atatcatttg
     5221 taattacatg gatttttatt gcatatctta tttacgattt gataatatta attttaggtg
     5281 gagatgaata cttagttaaa ttagtattat caacaggtgt aataagtgta tttataggtg
     5341 caggtcttgg acttattcca ggttgtggga tacaaattgt gcttatgtca ttttatttga
     5401 agggaactat accacttggt gcagtgatag ccaactctat ttctcaagat ggagatgcac
     5461 ttttcccact tttagcaatg gataaaaaat cttctttatg ggctatgatt attactacta
     5521 taccagcaat acttgtaggt atgatagttt atgcattttt aggttaaata taattatgaa
     5581 taaagaagta ttaaaaaaat aataaagcac ataaatttat ttataagaat agtgaagatt
     5641 aaatataaaa ataaaaaatt caatatgaat taaattattg cttaaatatt aatgagaaca
     5701 tgggagataa tattattcct catgttctct ctatttaatt aaaggaatta tggaacaaat
     5761 ttcaagtgat actttctatc aaaactcata tataatatat attaataaat taaactataa
     5821 tacgtaatac agtcagtata ttgatataaa aaacttagga ggagttgtaa aaatgggtaa
     5881 tttaaaaaga cagtgtgatg tttcaagtgg aagagaaaaa gctgacattg tactaaaaaa
     5941 tgggacaatc ataaatgtat ttacagaaga gttaataaca ggagatgtag caatagtagg
     6001 agacactatt gttggaattg gcgattacaa gggcaatgta gaaattgatt gtagtaacaa
     6061 atatatatca cctggcttta ttgatgcaca tatgcatatt gaatctacaa tggtaatgcc
     6121 aattgaatta tcgaaaaaat tattaaaatc aggtacgaca actatcatag ccgacccaca
     6181 tgagttggtc aatgtaaaag gagttagtgc aatagatttt ttattagaat cgacaaaaga
     6241 tataccactt aatgtatata ttatggtgcc ttcatccgta cctgcaacaa gttttgaaac
     6301 taatggagtt ggtaaattta gtgcaaaaga catggagagt tatgtaaata atcctagaat
     6361 tttaggttta ggagaggtaa tgtgttttaa tgatgttata aattctgaaa atgaaatctt
     6421 ggataaacta gagcttttta aaaataaagt tgtagatgga catgcaccta atataaatgg
     6481 taaatcactt cagacatatg tatgtgcagg aatagaaaat gaccatgaat gtataacttt
     6541 tgatgaagta tatgaaaaat tgagagcagg attaaaaatt ttaataagag aaggaagcgc
     6601 agcaaaaaat ttaaagtcta tagtaagtgg tatgctaaag cataacttgc caattgaaga
     6661 atttatgttt tgcacagatg ataagcactt agatgatata gaaaaacaag gtcacataag
     6721 atggaatata aaatgtgcga ttgatttagg tatggaacct gttagggcta taaaagttgc
     6781 aacttataat tctgcaaaag catatgggtt aaggaaaatt ggagcaatag gtgcgggtta
     6841 taaggcagat attgttgtat tgaatgattt agacaaaatg gaagtggata gtgtatataa
     6901 agatggtaat ttggtaaacg aagagatgtt ttctaattac aattatgaga ttaaagataa
     6961 agaattgctt aatacagtca agtttaaata tattaataaa gaaaaaatac agttaaaagt
     7021 aagtgaaaaa aattatgtaa tggagattgt accttatcaa attttgacaa ataaggtata
     7081 tgaatcttta ccatgtgcag atggatattt tgttccaaat aaagagtatt caaaactttg
     7141 tgttgttgag agacatagaa tgactggaaa tgtagcaatt gctccactaa aaggatttgg
     7201 cataaaaaat ggagcaattg ctactactgt ggcccatgat tctcataata ttatagttgc
     7261 aggggataat gatgatgata ttctagtagc tataaattac ttaaaggaaa tacaaggtgg
     7321 ttatgtaatt gtatcaaatg gaaaagttct tgcacaccta agtcttcaag tagctggatt
     7381 aattagtact tttacagctg aagaagtaca agaaattact gataatatgt tggagatagc
     7441 aagaaaaatg gaagttccag agtatgtaga cccttttatt acactttctt ttatggcact
     7501 tccagttgtt ccacaaataa gacttacaga tttaggtcta tttgatgttg aggaatttaa
     7561 atttatatag atagtataaa agtaataata aatgaggctt tctcaaaata gagataagtc
     7621 tctttttatt gttgaaatga tgaaaatata tttgatttca tacaaaaaag agcatctcat
     7681 gaactaaaaa ttttattttt agatatcctt attttaatta atctatcatt taacattgtt
     7741 ttaagcatag atatcttaat aaaactattt tcagtctatt ttaacatata aatacatgaa
     7801 aattatatat ttatgaaact ttatacataa aaaataaaat attttattta tatatagatt
     7861 tatagggtaa taatataagc atagtataaa attattaata aaaacaaaag gagagatatt
     7921 tatgttgagt ataggaacaa aagcaccaga atttacacta gaagataaag atggaaataa
     7981 ggtaagtatg tcagatttta aaggcaaaaa agtagtagta tatttttatc ctaaagataa
     8041 tacaccagga tgtacacgtc aagcttgtgc ttttagaaat gcatatgatg gatttaaaaa
     8101 ggaagatata caagttattg ggataagtaa agatagtata aaatcacatc aaaaatttgc
     8161 agaaaagcat gaacttcctt ttattttact ttctgaccct gacttagttg ctataaaagc
     8221 ttttgatgta tggaaagaga aaaaaatgta tggaaaaact gcattgggag ttgtacgtgc
     8281 gacatatatt atagatgaaa atggaattat tgaaaaagtc tttgaaaaag caaaaccaga
     8341 cacaaatgca caagagattc ttgaatattt ggaaaaacag gagtaataag aatttatgat
     8401 tataatgtta tcaccagcta aaaatatgaa gaatatagaa gtatttgata gagatttgag
     8461 tttgccttgc tttatagata acacaaaaga aatagtggaa aatataaaga catttggtat
     8521 agaagatttt aaaaataaaa tgaaaattaa tgaaaaatta gctgtattaa ataaaaatag
     8581 atttgaaagc attaaatttg atagattagg aaaccctgca atcttaactt atgatggaat
     8641 acaatataaa aatatagaag cagaaaattt tacaaggaaa gatgaagagt ttgcaaatag
     8701 ctgtattcga atcataagtg gattgtatgg tgttgtaaaa ccatatgata gtatatatga
     8761 atatagatta gaaatgcaga caaaattaca agtaggtgag tttaagaatt tatacgaata
     8821 ttggggaaat cgtatatata aagaactaat caaagaaaaa acagctatcg ttaatctttc
     8881 atcaaatgaa tacagcaaat ccatagaaaa atttattaaa gatagtgata catatattac
     8941 atgtactttt aaagtaaata aaaatggcat attgaaagtg gaatctacac aagcaaagaa
     9001 agctagaggt atgatgacaa aatacattgt aaaaaatagg ataagagata ttgaagaact
     9061 gaaaaagttt gatttagaag gttataagta taaagaaaac ttatctaaca atagtgaata
     9121 catatttgta aaagagtaga agttttgtta aatattaaat ggcattgtta aatttaggta
     9181 aaatatactt agtgtgtatt gaattgaact tgattttaaa atataattat tcttaaatta
     9241 aaaaaagaaa ggagtggtct tccaaaatgg aaaatcacaa acagatgcct tggcattcaa
     9301 gagcaacgca tgaaatttta gaaagtctag attcatcaga ggaggggctc accgataccg
     9361 aggcggaaaa acggcttaaa gagaatggct taaatgaact tagaaaaaaa ccacctagaa
     9421 caactttaca aatgctttgg agtcaaatta cagatgctat ggttatgata ctaataggag
     9481 cagcaatatt atctttgata tttggcgaat ttacagaagc ttttgtaata ctaataattg
     9541 taacagtaaa tgcagttatt ggaattgttc aagagaaaaa agcagaatca tcattagaag
     9601 cattaaaaaa tatgaattca cctacagctc gtgttatgcg tgatggtgaa gaaaatgtta
     9661 ttccagcaag taatcttgta gtaggagata ttgttttttt agaagatgga gctatggttc
     9721 cagcagacct tcgtttaata gaaacatcaa gtttaaaaat tcaagaggct tctttaacag
     9781 gagaatctgt tccatcagaa aaagatgcag atacaatctt acctaaagaa tgtgtattag
     9841 gagaccgtag caatatggcg tatacatctt caatagtcac atatggtaga ggtgtaggtg
     9901 ttgtagtagc aactggtatg gatacagaag tgggtaacat agcacatctt ttagattcac
     9961 aagatgattt tgatactcct ataaaacgta aacttaatac tgttggaaag acattaagtg
    10021 tcataggtat tattgtatgc gttgttatat ttgcaatagg tgcattttat cagagacctc
    10081 tcttgccaat gtttatgatt gcaatttccc ttgccatatc aattattcca gagggattac
    10141 ctgcaacagc tactattgta atggctttag gcgtacagcg tatggctaaa agaaatgctt
    10201 taattagaaa attacctgct gttgaaacat taggaggagc tacagtaata tgttgtgata
    10261 aaactggtac attaacctta aataaaatga ctgttacaca tattgctgtc aatggagatt
    10321 ttgaatctgg aaaagtgaca tcaatagata ctgcatctga aaaacatcca ttagtgtata
    10381 aagagattgt ttatgctggt gcactttgta atgatgcatg tattaatcca gataaaacag
    10441 atgaaatatt aggtgaccca acagagggcg cattaatttt tatggccaaa aaatttggaa
    10501 tagatcaaga agctcttgaa gaagaatatc cacgtgtatt tgaacagcct tttgattcag
    10561 atagaaaatg tatgacaact gttcataata tagatgaaaa gattattgct tatactaaag
    10621 gagcagtaga cgaaattctt gacctatgta ctaaaatatt aacttcaaaa ggtgaaagaa
    10681 acattactga agtggataaa aagaatatac acgaattatg tcttaacatg tctaaagatg
    10741 cattgcgtgt acttggtttt gctaagcgtg agatttcatc tataccaaaa gaagatagtg
    10801 aaaatataga atatgattta acatttatag gtatggttgg tatgattgac ccaccaagaa
    10861 ctgaggtaat tgatgcagta agtacttgta aagaagcagg tataagaacc ataatgataa
    10921 caggtgacca taaagttact gccacaacaa tcgctcatga gttaggaata tggagtgaag
    10981 aaaatactgt gatatctggt gatgaacttg ataatttgag tgatgatgaa ctagatgaag
    11041 ctgttaaaaa tactacagta tttgctcgtg tatccccatt tgataaactt agaattatac
    11101 aatctctaaa aagaattgga gaagtaccag caatgactgg ggatggtgta aatgactctc
    11161 ctgccttaaa gtctgctgat attggtatag ccatgggtat aagtggtaca gatgttgcaa
    11221 aagattcttc tgacatgatt ttaatggacg atagttttac aacaattgct tatgcaataa
    11281 aagaaggtag acgtgtatat agaaacatac aaaaagttat acaatttttg cttgttggta
    11341 atatagcaga gatacttacg ttgtttgtag caatattatt aaattgggat actccgcttc
    11401 ttgctgttca tattctatgg gtaaaccttg caactgctac gcttccagcc cttgctcttg
    11461 gagttgaccc accaagcaga aatataatga agcaccagcc agtgaaatca accactttgt
    11521 ttgaaaaaaa tcttatacaa agagttgtta cccaaggtgt atttgtggca ataatgacta
    11581 ttttagcata taaaattggt cttaatatag aaaatcattc tgtaggtcaa acaatggcat
    11641 tttgtgtatt agcattttca cagatgttac gagcatttag tcagcgttca aatacagatt
    11701 caatgtttaa tagaaataat ggtaaaaatc catttctttt aatctcattt ttaacttctg
    11761 catttttaat agcagtaata ctgtttgtac ctgtttttag aaatgctttt aacttaacag
    11821 ttttaaataa cttagagtgg cttataacga ttgttttagc cataatgtct gtaattcaag
    11881 tagaggttgg gaaaattatt aaaagaaaaa aattaaaaaa atagttgaca aaattaggaa
    11941 aaatatataa gatataaaac atagaaaaat taaataaatc ttatccagag aggtggaggg
    12001 actggcccta tgaaacccgg caaccagtat atttatatac attggtgcta aatcctgcgg
    12061 cgaaagctga gagatgagta taattaagct tatacagagc ctgagttata tactcaggct
    12121 ttatttattt taactctcat ctggtaaata gtttaatttt ttttactaaa atctaagggg
    12181 gatacaagaa tgtataataa agaaacaata tgtgtgcaag gaaattataa accaggtaat
    12241 ggagaaccaa gagtactacc tttatatcaa agtacaactt ttaaatatag cagtatagac
    12301 caacttgctg aattatttga tttaaaagtt gatggacata tatattcaag aataagcaat
    12361 cctactattc aagcttttga agaaaaaata agtttactag agggtggagt atcttctgta
    12421 gctgtatcat cagggcaatc tgcaaatatg ttggcagttt taaatatatg taaatcagga
    12481 gatagtatac tttgttcttc aaaagtatat ggaggaacat tcaatttact aggacctagt
    12541 cttaaaaaat ttggtataga tttaatatcg tttgacttag attcaagtga agatgagata
    12601 gtagaacttg caaaggaaaa tactaaggtt gtgtttgcag aaacacttgc aaatccaact
    12661 cttgaagtca tagattttga aaaaatagca aatgtagcta agagaattaa tgttccattt
    12721 attgttgata attcattagc atctccagtg ctttgtaacc ctttaaagta tggagcaaat
    12781 atagttactc attctaccac aaaatattta gatgggcatg cttcaagtgt tggaggaatt
    12841 atagtggatg gtggaaactt taactgggat aatggaaaat ttccagaatt agttgagcca
    12901 gacccaacat atcatggtat aagctatact caaaaatttg gaaatgccgc atatgcaact
    12961 aaagcaagag ttcagttgct tagagactat ggaaattgtt taagcccatt caatgcgtat
    13021 cttactaatt taaatgttga aacactacat cttagaatgg agagacatag tgaaaatgca
    13081 cttaaaatag ctagattttt agaaaaacat gaaaatgtag attggattaa ttacccagga
    13141 cttgaagata acaagtatta tgagaatgcc aaaaagtatt tatcaagagg atgtagtggt
    13201 gttttatcat ttggagtaag aggtgggtta gaaaatgcca aaaaatttgt ggaaaaatta
    13261 cagatagcat ctttggttac acatgtttca gatgtaagaa cttgtgttat acatccagct
    13321 tcaactactc atagacaatt aacagaagaa caattaattg catctggagt attgccttca
    13381 ctaataagat tatctgttgg aatagaaaat gtagaggatt taatagctga tttaaatcaa
    13441 gctttaaatt tctaatattc taagagaaag agaagtgaaa agatatggct ttaatactac
    13501 caaagggatt acctgttatt aataaattat tagatgaagg aatagatgta atttataaag
    13561 aagattttaa aaaggaatta aagtatgaag aaaacataga cactaagata gctatactaa
    13621 atctaatgcc tataaagata gatacagaat tagatttact aagaaggata gataaaacag
    13681 gattcaacgt gtctgtggaa tttattaaaa tttcaacaag agaaagtaaa agaagttgta
    13741 atgaatatgt taaagaattt tataaaacat ttgatgaagc caaaggagag tattttgatg
    13801 gctttataat aacaggagct ccagttgaac aaatggagtt tgaagaagtt gattattgga
    13861 atgaactaga agaaattatg gattattcta agagaaaaac taaatctaca ttatatatat
    13921 gttgggcagc tcaagcaagt ctttacaaat actacaatgt aaaaaaactt ccactaagtc
    13981 aaaaatgttt tggagtattt aagcataagg tagataaaga tagtaaaata gtagatggat
    14041 ttgaaaatga attttttgct ccacattcaa gacatactac tgtaaatatt gaagctttga
    14101 aagagaataa agagttgagc attgtgagtc attctaaaga agctggtccc tatataatta
    14161 caaattcaag agatgtgttc gtaatgggtc atagcgagta tgacaaatac actcttgata
    14221 aagaatataa gagggatata aataaaggag ataaaatatc tatacctcaa aattactata
    14281 ttaatgatga cccttcagaa gagccaactg taaaatggaa aaaacattca gaattgttgt
    14341 ttagaaattg gataaaaaac tatttgatac aataaatttt aagagtatat aaatgttaac
    14401 taaaaaaata tagaaattta taggtataaa gttaatctta atgatacttt ataccttatt
    14461 ttttttaaat ttgaccttat aatagtagtt ttatatttta agaaaatcac tttaggtgta
    14521 tgtagataga ggtggcttta attttatata tggtgcgata atgggagact aaacctttat
    14581 agtatcaata aatttgtatt ttaactttta aaagagatta aaaagggaga aatcagtgta
    14641 aaatatatat atagattttt tattaaattt tattaaaaat atcctgtata aaattaaata
    14701 tcaataagat aacaaaattc caattgaagt tacaatattg taattgacaa taaatactta
    14761 atactataat atttaataca ttaaacatta tagtgttaag tatttattta cagtatgcac
    14821 ttcagcctaa atttgaaata aagtattttc gtagggagcg tttgtatgga tgagatgagt
    14881 tttaagaaag agctactaga gttgactaga gatataaata tgaaatttac aactttatta
    14941 agtgattttt atcagccact tggtattaca gcagtgcaag ctttgatttt atctgagtta
    15001 tgtgaacatg gagagaaaaa aataagcgat ttagggaaga acttaaacat gacaaatagt
    15061 aatgtatcag taatctgtca aaggcttgaa aaaaatggct ttttaaatcg cataagagat
    15121 atagaagacc aacgaattgt aaaagtaaaa gttacaaata aatcattgga tatacaagaa
    15181 catatttcaa gtagtatttt tgatagttat tttgaaaata tgaccagtga aaaattgcaa
    15241 gatatggaag atataataga aggtttagag aaattaaata aacttttaac ttacattgat
    15301 tgcaaataac ataaaaataa tttaaaggag aataaaatta tggatgaaca taaaccccaa
    15361 aaaaggtcag cactctatta ttatacagtt ataataatag tagtaatgtt tttaaatgct
    15421 ttaatatttc caagtttaat ggataaaaaa atggttgaga ttgactatgg aaagtttctc
    15481 acaatgttgg atacaggaaa ggttaaatct gttgagatag aaaataatag aatagcaata
    15541 aatccatcta gtagcaagga taagaatata tacataactg gtagaatgga tgacccagaa
    15601 ttggtagata gactaaaaaa tgcaaaagta gaatttacta aggttattcc taaggaaaat
    15661 tcacctcttt taagtatttt acttacatgg ataataccta taggtattct tatgctattt
    15721 ggtaacttaa tgatgaagtc tatgcaaaag cgaatgggtg gtaatgctat gcaatttgga
    15781 aaaagcaacg ccaaaatgta tgtatctgct caaagtggaa aaagatttaa tgatgtagct
    15841 ggtcaagatg aggcaaaaga agctttaact gaaatagtag atttcttgca caatccagaa
    15901 aagtataaaa agataggagc acaaatgcct aaaggagcac ttttagtagg acctccaggt
    15961 acaggaaaaa cactccttgc aaaagctgta gcaggtgaag caaatgtacc atttttctca
    16021 atatctggtt ctgagtttgt tgagatgttt gtaggaatgg gagcttctag gattcgtgat
    16081 ttatttaaac aagcaaaaga aaaagctcca tgtatagtgt ttatagatga gattgatact
    16141 attggtaaaa agcgtgataa tggaagtgga ttaggtggaa atgatgaacg tgaacaaact
    16201 ttaaatcagt tgttaagtga gatggatggt tttgatggtg gaattggagt agtaatactt
    16261 gctgctacaa atagacctga cagtcttgac aaagcattac ttcgtccagg aagatttgat
    16321 agacgtatac cagttgaact tccagacctt ggaggacgtg aagctatatt aaaggtacat
    16381 gctcaaaatg taaatgtaag ctcagatata gattataatg caattgcaag gtctacatca
    16441 ggagcatcag gtgcagaact tgcaaatatt gtaaacgaag cagcactttt agcagttaag
    16501 tctggcagag atatagtaga acaacaggat tttgaagaat ctgttgaaac tgtaattgct
    16561 gggtatcaac gtaagggagc tgtaatttca gataaggaaa agaaaattat agcatatcat
    16621 gaaataggtc atgcacttgt tgctgctatg caaaaacatt ctgcacctgt ccataagatt
    16681 actataatac ctagaacttc aggagcattg ggatatacta tgcaagttgc tgaagatgag
    16741 agtgtactta tgtctaaaga agaagcaatt gataaaataa ctacttttac aggtggtcgt
    16801 gctgctgaag aggttatctt taacacttgt acatcaggag catcaaatga tatagaacaa
    16861 gctactaaaa ttgcaagagc tatggttact cgccttggta tgagtgaaga gtttgatatg
    16921 gtcgctcttg aaactgtaag caatcaatat ttaggaggag atacttctct tgcttgttct
    16981 tccgacactg ctgctaaaat agatgaagag gtatttaaaa tagtaaaggc ttgtcacaaa
    17041 aatgcaattg aaatcttaga aaataatatt gataaattgc atgaacttgc taattattta
    17101 ttagaaaaag aaactattac aggtgatgag tttatggaaa tacttaactt aaactaaaat
    17161 gattatacac aagataaaaa tgcctattgt taggcatttt tattttacaa ctaaattttt
    17221 taaattcata tttaaatctt tacataatct taatcattaa aaatacatct taactacaat
    17281 tttatatcgg aattgatatt ataatagtaa tgaatggtgt aaggaggttt tttaatggat
    17341 agacctaatc ctgatattct attagaaaaa attaaaaatg aagaagaaaa actaagtaga
    17401 ggtcaattaa aaatattctt tggttatgca gctggagtag gaaaaaccta ctctatgttg
    17461 gaatctgcac aaaatttaaa aaaagtgggt gtggatgtag tagttggata tattgaacca
    17521 cacactagac cagaaacatt ggctttactt gatggcttgg aaattcttcc tgtaaaggat
    17581 atagaatata aatctataaa actaaaagaa tttgatttag atgctgcttt agcaagaaaa
    17641 ccagaagtta tattagtaga tgaatttgcc cattctaatg ttgctgggtt aaggcataca
    17701 aaaagatggc aagatataga agaattgctg ttagcaggca taaatgtcta cactactgta
    17761 aatgtacaac atttagaaag tctaaatgac attgttgaga taattacaaa cgtatcagtt
    17821 aaagagacta taccagataa gtttttggat acaaatacac agttagaact tatagatgtt
    17881 gaacctgatg tacttcttga aaggttcaat gaaggtaaga tatataagaa agaacaagct
    17941 actagagcaa aaaataattt ttttataaaa gataacttgg ttgcacttag agaaatcgca
    18001 cttagaaaaa cagcagagag agttaataaa gaagttcaaa tgaccagact atcaaagggt
    18061 gatgtaactg taatacctac atcagataca cttcttgcat gtataagtcc atctccatct
    18121 tcagcaaaag ttattagaac tgcatccaga atatcagaca gtacatttgc aaaatggata
    18181 gctttatatg ttgaaactcc aaacacagca agacttccat ttgatgaaca aaaacaacta
    18241 caaaataacc taaaattagc taagaaatta ggtggagaaa taattgtttt acatggtgaa
    18301 aatataatag agcaaatact tagaattgca aaactgagaa atgtaacaaa aattgtaata
    18361 ggtagaaatc attcaagtaa taaaagattt agtaaaagat ttaaaaaaga tatagttgac
    18421 aaattaattg atgaagttga ttatatagat atacatataa ttccatataa atttgcctca
    18481 gatgttaaat acaaacctaa aaaggataaa tcatcaataa aatctaaatt taaaattagc
    18541 aaagttgatt ttataaaact tatatttatt actttgatga taagtatttt agcatatgca
    18601 gtacaaagca tgggatttat aagagaaaat atattgttaa tatatatgtt gggtgtagtt
    18661 ttagtttcta tgtggactaa agggtatagt acaggtataa taagttctgt atttaatata
    18721 gttcttttaa attatttttt tacagcacca ttatatacat tatctatagc agattcaaac
    18781 tatatagtaa cactggttgt attctcaata gtaggtataa taactagcac tcttacgtct
    18841 aagatacagc atgaagcaga aactgctgct aaaagagaag aaaatacaaa aatgatatat
    18901 caaataatta agggattttt aagattatca aataaagatg atatagtaaa caaaggtata
    18961 gaacttttgt ctcttagctt aagtagagat gtaatttgtt atttaaatgt agataagcat
    19021 aataaatcaa agctttacaa aaaaaatact aataataagg ataaaaatga tttggatagt
    19081 gaagatgaaa aagctgttgc aagttgggtt ttatccaatt caacagtggc aggaaatgac
    19141 acggatacac ttcctggttc aaagggatac tatataccaa ttgtaggaat gaatttaact
    19201 ttaggagtag tgggaatatc atgtattgat tcaaaattgg atacagaaga tataagctta
    19261 attgaaacaa taattgctca aatggcaata gcgcttgata gagaaatctt gtcagaagct
    19321 aaagaaaata ccaatcttga gattgaaagg gaaagattaa gaagtaatct tttaagagca
    19381 gtttcgcatg accttagaac tccactagca ggaatatctg gtgcagtaag tacaattata
    19441 aaaaacaagg gtactatagg tcaagatata atagatgaat tacttagtgg tgtatatgaa
    19501 gatactcagt ggttaataag acttgttgaa aatttactta gtatgaccaa gatagatgaa
    19561 gggaaattgg aagttaaaaa acattctgaa ctggttgagg aaattatatc agaagcgtta
    19621 caaaaaataa aaaaaagaat tgaaaatgca cttatagata ttaatatacc agaacagata
    19681 ttatttgttc ctatggatgc aaaattaata gaacaagttt taattaattt aatagataat
    19741 tctttgaaat attcaaagga agattgtaag atagagataa atgtatatga gaaagatgat
    19801 tatgtttggt ttgaagtatc tgataatggt cctggtatat caaaggaact taaaaagcat
    19861 atctttgaca gattttttac tggagaagaa ggagctaaag attccagaaa gggtgttgga
    19921 cttggattat caatttgtaa atctataatt caagctcata aaggtgaaat tatggtagaa
    19981 aacaataaag ataagggttc aacttttaag tttagtttgc ctaaggaaaa tgaatagttt
    20041 taaattttaa aattagtttt ggaggaagaa atgagtaaaa aacttatatt gttagtagag
    20101 gatgataaga caataagaaa atttatatct actgcacttt taacacagga ttatgatgtc
    20161 aaggaggcta taactggaaa agaaggtata tctatagctg tctcatattc tccagatgtt
    20221 gttcttttag atttaggctt agaggatatg gatggaatag aggtaataaa agctatcaga
    20281 caattttcaa atataccaat aattgtagtt tcagctagag agcaagatag agacaaggta
    20341 gaagtatttg atgcaggggc agatgattac ttaacaaaac cattctccat agtagagtta
    20401 ttagcaagag taagagtagc atttagacat tcacaagtag aagctcaaca aaaagatgat
    20461 gttaaatcta cgtttgaagt agataaatta ttgattgatt ttgataaaag aaaagttatt
    20521 gttgatgatg ttgaagtcca tttgacacct attgaatata atattctttc attacttgca
    20581 aagcatcatg gaaaagtgct tactcataat tttataataa aagaaatatg gggtagtgtt
    20641 atagggaatg agactaagtc tttaagggtc tttatggcaa cgttaagacg aaaaatagaa
    20701 aaacaacctg caaacccaag atatataatt acagaagttg gtgtaggata cagattaaat
    20761 gatgaatagt tgtaatatat taattattag attatgtgct tattaatata tattaaaatt
    20821 atatagttta gttaaaataa gaatgaagtg tatgtgcttg ttgtcagttt agcacatgca
    20881 ttttattttt tagctttttt agtatcaata attttttagt atcaataata tgaaatatgt
    20941 tttaaaataa gtatatagtg taatctgtaa taaaaacttt ggttaaataa taaatgtatt
    21001 taacacttac cttataataa atttaatata aatattaaat aataattatt aaaatagtgt
    21061 aaaataatta cagtaaggat tataaaaaat ttttagaatg taaattgaaa tttaggagta
    21121 gatgtatgta tatactgaat ttaaatacaa gagagactat tgaagatttt agagataaat
    21181 tttatgtagc agaaaattct tatcttatat taagtgctcc aaaaaattta aaattgctta
    21241 aggaaacttt ggatatagat gaaataactt ttaatgattg tcttaaattt gatgaaataa
    21301 ccaaacttga tttatttgat aattacgatt ttttaagcct aaatacattt gaactaagag
    21361 atggagaagc tgttatagaa gaggtaaata tgtatttatc agataatttt atattggttg
    21421 tagtgaatga agaacacttt ttatttgaat ttgtaaaaaa tattattttg aagaactctc
    21481 aacttgaaaa aaatccagtt attaatctat ttaagataaa ctacttgatt cttagagaag
    21541 ttataaaaaa tggttttgag tctttggaaa aagttgaaga gttaattctt caaatagaag
    21601 atgaaatgat ggacaacatt aataagaatc atgtatctag aataagtgat gtaagaggat
    21661 taacaagaat tatagttaag aatactagac ctcttttgta tattggggat agaatagtta
    21721 aggaaaatat aagatattta aaatattcaa atgtaaaaaa atataattta gaaaattttc
    21781 aaggtataga ttttggaatt gacaaattat acaatttcgc attgtcaaca cgagagttag
    21841 cagataaatt attagatatt tattcttcca gagtaggtga gaaaacaaat aacttaatta
    21901 caaaattaac cttgttaaca gccatatcag caccacttac aattataact ggtatatatg
    21961 gaatgaactt tagatatatg ccagaattaa actggattta tggatatcca gcaactttat
    22021 tttttatgct atgtataatt tttgttggaa ttataatatt taaaataaaa aaattattgt
    22081 aaattacaga tgatgtttaa ttgattttat aaaaatacat caattgagaa gctgatttaa
    22141 gtaaataaaa aaatatttta aattgaaaat atttatagaa aatattgaca attatatttt
    22201 ctttgttata attattaaac aagaagaata ataaattata aaaatggagg ataatactat
    22261 gaaaggaata ttaaaagaac taacagcaaa actttatagc tttttttact ttatgttctg
    22321 gggcttttat tttagcgctg gctatttctt ttacaaaaat atatgtactt cctttctggt
    22381 gaggccttat tttagtgatt ttgagcataa gtaaatttta taaaaatggt tattttatat
    22441 atttatataa gatttagtgc ttgatagatt attttagaga actcattagt gagttctctt
    22501 ttttatttta aatataaaat tataatattg ggaggtagta aaaatgatag tagtattaaa
    22561 aatgggagca gacaaaaatg aagttaaaaa attaattgag gctattggga gagaaggagt
    22621 agaagttaat cccatagatg gaacagaatt aactgtttta ggtttagttg gagatactag
    22681 taaaatagat gccaaaagaa tagaagcaaa taaggtagtt gaaaaagtta tgcatgtggt
    22741 agagcctttt aaaaaggcca atagaaaatt tcatccagaa ccttcaatca taaatgttaa
    22801 tggaatggaa attggttcaa agaaaattgc tatgatagct gggccttgtt ctgttgaaac
    22861 agaagaccaa atagtatcta tagctaaaga tgtgaaaaaa tcaggtgcag gatttttgag
    22921 aggtggagca ttcaaaccaa gaacatcacc atacgctttc caaggattga aatatgatgg
    22981 attggattta ttaaaaaaag caaaagaaaa aacaggactt cctatagtta cagaaataat
    23041 gtcaacacaa gatatagata tatttgaaga aaatgtagat gtaattcaag ttggagctag
    23101 aaacatgcaa aactttgatt tattaaaaga attaggtaaa acaaataaaa caatactttt
    23161 aaaaagagga ttatctgcta caattgaaga gtggctaatg tcagcagagt atataatggc
    23221 tggaggaaat gaaaatgtag ttctttgtga aagaggtata agaacttttg aaacatatac
    23281 tagaaatact ttggatttaa gtgcaatttt agctgtgaag aaacttagtc atttaccagt
    23341 tatagttgac ccaagtcatg cagcaggtaa atcatggatg gttgactctt tatctaaggc
    23401 agcaattgca gttggagcag atggtctaat aatagaagtt cataatgacc cagcacatgc
    23461 actttgtgat ggaaaacaat cgattaagcc aaatgaatat gatgaattga taagtgaatt
    23521 aaagactatc gcatcagcag ttggtagaga aatataatct ataaaaggat ggttaaacgt
    23581 ggaagaaaaa ctattagtaa atttaaaaga aaatagctac aatatattta ttaaaaaaaa
    23641 tatactaaag aatataggag aagaaataaa aaaaatatat tttggaaata agatttttat
    23701 tgtaactgat gaaaatatag caaaattata cttggataaa gtaaaaaata atttaagtga
    23761 atctggattt gaaattaaat ctttaatatt aaaatctggt gaagaaacaa aatcatttaa
    23821 tactcttcct aaaatatacg atagtttact tgactttaag ttaactagaa aagatttgat
    23881 tattacttta ggaggagggg taataggtga tttaggtgga tttgcagcag caactttttt
    23941 aagaggtata agttttattc aaattccaac atctttatta gcacaagttg atagttctgt
    24001 aggtggaaaa gttggagttg accttgagag aggcaaaaat ttagtgggaa gcttttacca
    24061 accaaaggct gtgtttatcg acccaaatgt attattatca cttccagaaa aattctatag
    24121 agatggaatg gcagaagtta taaaatatgg atgtataaaa gacaaaactt ttttcgataa
    24181 acttttaagt ttaaaaaata gagaagaagt aatgcaacat atagaataca ttatacataa
    24241 atgttgcttt attaaaaaaa ctgtagttga agctgatgaa aaagactttg gagatagaat
    24301 gcttctaaac tttggccata cattaggtca tgctattgag aaatactaca attttacggg
    24361 ttatacccat ggagaagctg ttgccatagg aatgtataag ataactttag aaagtgaaaa
    24421 gataggaatt acaaaaaaag ggacatcaga acttataaaa tcaattttaa tgaattataa
    24481 tttgccttat gagattgaat taagagataa taaatctata gtagatgcta tatctcttga
    24541 taaaaaaaat ctaggtgata cattaaaaat aatactttta aaagatattg gagagagtat
    24601 tatatataat actacttcta aattttttca ggaggtaaga taatgggaag tctaaaaata
    24661 tatccaagta aattatctgg agatgtaaaa ataccaccat caaaaagtat ggcacatagg
    24721 gcagttattt gttcatctct aagcaatgga aaaagtagaa tttctaatat agatttttct
    24781 gatgatataa tagctactat aagagcaatg acatcattag gagctattat agaaaagaaa
    24841 gaagatattt tagaaatttc ggggattttt tctaaagaag gtattttaaa tagagagaat
    24901 cagttgaatc aacctaaatt gacaatagat tgtaatgaat caggctctac attgagattt
    24961 ttagtaccta tatctttagc atttgatggt ataaaaaggt ttataggtag aggtaatctt
    25021 ggaaaaagac cacttgatac ttattatgag atatttgaca gacagaatat aaaatatagt
    25081 tacaaagaaa atcagttaga tttgattata tcaggtaagc ttaaaccaga tgaatttaga
    25141 gtaaaaggaa atataagttc tcagtttatc acaggtctac tgtttatatt gcctacgcta
    25201 gagagtgatt caaagataat aattactact gagctagaat ctaaaggata tttagattta
    25261 actctttcaa cgataaaaga ttttggggta gaaattataa acaataacta taaagaattt
    25321 attataaaag gaaatcaaac gtataaagcg agagattata aagtagaagg agattattct
    25381 caaggagcat tttatttatc agcagatgct ataggagaag atattagcat attagacctt
    25441 aaagaagatt ctcttcaagg ggatagtgaa gtagttgaaa ttttatctag gatgggaatg
    25501 gaaatattaa gagaaggcaa caaaataaaa ggaataacaa atggtttaaa tggtactttg
    25561 atagatgcat ctcaatgccc agatataata cctgtattat ctgtagtagc atccttaagt
    25621 atagggagga ctacaataat taatgctggt aggcttagaa ttaaagaatg tgatagactt
    25681 catgcaataa atgttgagtt aagtaaactt ggagcaaata tagaggagaa agaggatagt
    25741 ttgataatcg aaggagtaag caagttaaat ggtggagtag aggtgtggag tcacaaagac
    25801 catagaattg ctatgacact tgcaattgct tcttgtagat gtgataaacc aataatatta
    25861 aaagattttg agtgtgtatc aaaatcttat ccacattttt ttaaagattt taagatgtta
    25921 ggaggtcgaa ttgatgagtg gaatatgggg aaataattta aaagtatcaa tttttggaga
    25981 atctcatgga aatgctatag gtataaatat agatggtctt ccttcgggga ttgaacttga
    26041 ccttgataat attgataaag aaatgaagag aagagcacct ggaaaaaatt ctatatctac
    26101 ttcaagaaat gaaagtgata taccagaaat tctaagtgga tattttaatg gaagaactac
    26161 aggaacgcca ttatgtgcaa tcataagaaa tagtgatact cgttcaaaag attatggaga
    26221 gcttaaaaat ttaatgagac caggacatgc agatttcaca ggtaatgtga gatattctgg
    26281 atttaatgac tatagagggg gaggtcattt ttcaggtagg ataacagctc cattagtatt
    26341 ttgtggggct atatgtaaac aaattttatc acaaaaagga atagagatag gagcacacat
    26401 aaaaaaaatt aaaaatatag aagatatgag ttttgattat gtaaatattt caaaacaaca
    26461 gttatcaaat ttgcaaactt tggaactacc tttacttgat ttatcaaagg aagaagccat
    26521 gaaaaatacg attatagatg caaaaaatca aggagattca gttggtggta taattgagtg
    26581 tgcagtagta ggtattaatg tagggcttgg aaatccattt tttgactctg ttgaatctac
    26641 tttatcacat ttattgtttt ctgttcctgc tgtaaaaggt gtagagtttg gtttaggttt
    26701 tgaacttgca gatatgtatg ggtctcaaag taatgatgaa atgtattatg aaggaaatca
    26761 agttaagagc aaaacaaata acaatggagg aattatagga gggattacta ctggaatgcc
    26821 aataattttc aaagtggcaa ttaagccaac tccatcaatt agcagacaac aaaacacagt
    26881 taatataaaa gataaaaagg acgatatttt atatattaaa ggtagacatg acccttgtat
    26941 agttcaaagg gctatacctg taatagaagc agtaacagcc attggaattt ttgatttgat
    27001 gaaaggacga taataatgga ggatttaacg agatatagaa atgagattga caatatagat
    27061 aaagagctta ttcaattatt tgaaaagaga atgaatacag ttcttgaaat tgccagacat
    27121 aaaatgaaaa ataacactac tatacttcaa aaagatagag aagaaaaagt actaagtaga
    27181 gctgtagata atttagataa taaagcatat tcacaagaaa cggtacagtt ttttaattct
    27241 ataatggaaa ttagtagagg attacaaaaa agattgatag ataatgatgg tgagcagaaa
    27301 atcgagttta gtttagattc atcaaataag aaatttgatt tgtcaaatgt aaatagatat
    27361 aagtctttaa aagatgaatt aaataaaaaa aatatcctag tagggttttc aggaaaatca
    27421 ggttcattta cagaagaagc actaaataaa ttcttcaaca aaaaaatatc aaaaaaacaa
    27481 tttaaagaat ttgaagatgt tttcatagca cttaaaaata aagaaataaa ctatggaata
    27541 atccccatag aaaattcatc tacaggagct atctctgaaa cttatgacct tttgagaaag
    27601 tacggttttt atatagttgg agaagaatgt ataaaaatag accaaaattt aatagggata
    27661 aaagacacaa agcttgaaga tataaaagaa atatattctc atccacaagg tataggacaa
    27721 tgtagtgaat ttttaaaaca aaatagtaca tggaaattga taccatttaa taacacagca
    27781 acaagtgcag aacttgtaag gaaacttcaa gataaaacaa aagcagcaat tgcaagcaaa
    27841 aaagctgcaa gtatttatgg attagaaata ataagtcctt gtataaatga tattgcaaac
    27901 aactatacaa gatttgtagt aatcagtaat caaatacaca ttgaagaaga atcaaacaaa
    27961 atgagtgtag tattttctgt tgaacatgaa gcaggaaaac tttataaagt acttggatac
    28021 tttgctaaaa ataatataaa tatgacaaaa atagaatcaa gacctatgaa aaatgcctca
    28081 tggagatatt tcttttatat agattttgag tgttctatat acaattctaa agtgtacgat
    28141 ttattagaat tgatagaaca taatacagca tattttaaat ttatgggagt atataaaaat
    28201 aaaactgaat agataagata aatttttatt taatttataa ttattaggag gtgtaagtat
    28261 gaattttttc ggtctagtag gtgaaaaact ctctcacagt gtttcacctc aaatccacaa
    28321 gagagtattc gagatattga atattgaaag tgcttataaa aactttgaaa tttcaaaaga
    28381 agatatatct aagctagacg gtgctataaa attattagga atacaaggag taaatgttac
    28441 tgtaccatat aaggagcgta ttatgaaata tcttgatttt atatcaccag aggcaaaacg
    28501 tataggagca gttaatacaa ttttactcag agaaaatatg ttatatggtt acaatacaga
    28561 ttactttggt cttgatagta tgtttaaaat ggctaatatt gatgttcaag gaaaagtagc
    28621 agttatatta ggaactggag gtgcttctaa agctgctctt acatatttta ttgattctgg
    28681 tatagaaaag ctttatgttt caactagaaa aaaggatgat aaaaaattat taaatagtaa
    28741 agctatatta atagattatg aagaacttaa acatataaaa ggagatataa tattaaatgc
    28801 tacaccagta ggtatgtacc ctaatgtagg aatttcacca gtgtcaaaat ctattataca
    28861 aaattttgat atattaatag atttaattta caatcctgga gaaacagagt ttttaagaat
    28921 tggtaatagt atgggtaaaa aaacttgtga tggattatat atgctggtgg ggcaagcaat
    28981 aaaatctcag gaaatttggc aagatactaa aatagataat agtattttag atgttatata
    29041 taatgaacta aaattagaat ttttgtaagg gagattgtta tgataaataa aacaaaagaa
    29101 aaattgatat taataggtat gccaggtagt ggaaaaacta caattggtaa acttttggcc
    29161 aaagaatata attgtagttt ctgtgatatg gatgattata taattcaaat atctcaaaaa
    29221 agtatagcag agttgttttc agaaggagaa gatatcttta ggaactatga gactcaagca
    29281 tgtagagaac tttctataag tgataaaaca gtgatatcta caggtggagg tgtaataaaa
    29341 aaggatgtta atatggaaat actaaaagaa acaggtataa taatttttat tgatagacct
    29401 atacaaaaga ttttggaaga tataaatatt aattcaagac cattattaaa aaacggaaaa
    29461 gatagattgt ataatcttta caatgagaga ataaatcttt ataaaaaatt ttcagatata
    29521 gagattttaa atgataaatc attaaataat gctgtatata atattacaaa tgcagtcagt
    29581 gaaaatttta aatttgactt taaagaaaaa taatctaggg ggaagtaaaa ataatgaata
    29641 ttgttattgt aggactagga gttataggag gctcttttgc taaagcatta aaaaaagctg
    29701 gatatgaaaa tgtatttgga gtagatgtag atttagaaac tttaaaaaaa gcagaaaaat
    29761 caaaaatcat aaaaaaagga tgtactacag gtaaagagtt atttaaaaaa gctgatttaa
    29821 ttatactatc tatatatcct agattagttg tagattttct aaataataat aaaaactttt
    29881 ttaaaaaagg gactataatt actgatacta caggaataaa agaaacactt atcaatgatg
    29941 tgttgcaaat tattccagat gatatagatt ttatatttgg acatccaatg gcaggtaggg
    30001 aaaaaaaggg tattgatttt gcaagtgaac aagtttttaa tggcgcaaat tatataatta
    30061 ctccaactgg cagaaacaac ataaaaaatt tagagttagt tgaaaattta attttagaga
    30121 ttggatttaa aagagtaaaa aagttaactt cacaaaaaca tgatgagatt atagctttta
    30181 cttctcagtt acctcatgtt atggcagttg ctcttataaa tagtgatgaa gaaggtagag
    30241 atacgggtaa atttattgga gatagttata gagatttaac tagaattgca aatatgaatg
    30301 aagacttatg gagtgaactt tttttaggaa atagagataa tttactaaaa gttatagaaa
    30361 actttgaatc agaagtaaat ttagtaaaag aagctatatt taacaatgat aaaaataaat
    30421 taatagagta ttttaaaaaa tcatcaataa gaagagaagc tttagaaaaa taaatattaa
    30481 tatttaagct atatatagat gggtataaat ataagcgata gtgtatttaa ttgtattaat
    30541 aaatatggat tcaatataat taaatatgct attgatatat ttgtaccctt aactattgtt
    30601 atcttttaaa tgataatgat atttatttaa atactcttta ttaacaattt ataaaactta
    30661 attgtaaaaa atacttatta atagtaaaat aaagtgaatc aattatatta taattgctaa
    30721 agagagtgag gtgtagctat ttgaaaaaaa atagattaat agcaaagaat atatcaatag
    30781 catttatagt actattcttt tttagtgtat ttacattttt ttatgtaggt aatattaata
    30841 gagtgttaga atatgaaaca aatgacataa taacagttac aattgctgga tggattatac
    30901 tttcattttt atttttaggt attataattt acatattata ttcaaaagca aatagtcaaa
    30961 aaactataga aaaagtagca tatacggatt ttgtaacagg ttattccaac tggagaaagt
    31021 ttgaattaga tgttacaaat ttattaaaga aaacatcaca aaataataaa tatgcaatgg
    31081 tcatattcga tattgataaa tttaaagcaa ttaatgatat atatggtcat aaaaagggaa
    31141 atttaatatt aaaagatatt gcagatactt taaatgaatt gactaatatc aatgaaactt
    31201 ttgctcgtgt aagtgctgat agttttaata tattattaac atataacaaa aaagaggata
    31261 taataaatat tatcaaaaag attatggcaa ataatgaact tgtaaactta tcttttggaa
    31321 tttatgaaat caaagataag gatttatctg taagtgtata tagcgataga gcttcacttg
    31381 caaaatcatc aataaaaaat aatagtgatg taaattttgc attttttaat gataaattaa
    31441 gagagaaatt attacttgaa gataagatag aaaaagaaat ggaatatgct cttgaaagtg
    31501 ggcaattcgt aatgtattta caaccaaaat acaatattaa attagataaa ttttgtggaa
    31561 gtgaagccct agtcagatgg caatatacag aaaaagaggt catatatcca ggtgatttta
    31621 ttcctatatt tgaaaaaaat ggatttatta gaaagattga tatgtacata ttagaacaag
    31681 cttgtaaaga aatccggtct ttatttgata aaggaatttc acctttacct atatctgtaa
    31741 acttctcaag agttgatttt tttaaaaaag attttattga aaacatagta aatatatgtg
    31801 atagatataa aataccatat agtttaatag aaattgaaat tactgaatct agtatgtttg
    31861 gagatactga tactctattt aatgttagta gaaacctaca ggatattggc tttatagttg
    31921 caatggatga ttttggctcg ggatattctt ctgtaaatat gcttaaaaat ataccattaa
    31981 atgtaataaa attagataga ggattttttg ttgatgataa agatgttgat aagagtcaaa
    32041 ttgttataaa aagcatagtt tctctcatta agcaattagg aataagggtt gttgctgaag
    32101 gaattgaaac aagaagtcaa atagaaatgt taaaaaaagc aaattgtgat attgttcaag
    32161 gatattattt ttcaaaacca ttaccaatta aagaatttga aaaattagtc tataaaatat
    32221 agtcagcgag tcttaaatgg gaggtggtga ttaagtgata agagcaaaat cgttaaaaaa
    32281 tgtactgagt attgttttaa tatttttatt tacaataatt tctttttctg attttgcatt
    32341 taaaactaat gtccaggaag aagaaaatag taaaattaat ttaagggaaa tatccctaca
    32401 aagttccaat gctataaaaa taaaattaga tagttctcta tcctttatta aaagtgtggc
    32461 aaatatggtt tcttatttta atactataga taactcaaaa atagttccat tattagctaa
    32521 tatatcaaaa gaatctgact ttcaaagaat ctctattgta tctcctgatg gaataagtca
    32581 taccagtgat ggcaaaatta tcaatgtgtc aaagtatcag tattttaaga aagctattaa
    32641 aggagaaagt aatatatctg aagttgtgaa atctccaatt gatggaaaag atacttttgt
    32701 tatagctact cctgtattta ataagaataa caaaataatt ggtgttttat acggttctta
    32761 ctacaatgat aaattagctg aatttataga tataacaagt tttaatagtg aagggtacat
    32821 agatatattt gaatctagtg gtcaatttgt tttaaaatct tcacatacaa acaaactgat
    32881 taagtcaagt agtaacatat atgatatatt taaaaaagct tcttttgatg atggttatag
    32941 ctataaaaaa atatatgaag atacaaaaaa taacaagagt ggctttacct catatgaata
    33001 caaaggagaa aatcgttatg ctacttatac acccattggt gtaaatgact ggtatgtaat
    33061 ttctgtgata ccacaatata ctgtaagaag aaacattgat aaaataaatc aattagcatt
    33121 ttctcttatt ttcaaggtat tcttattgtt tattatgctt ataatatata ttatttataa
    33181 aaacaataaa tctcagaaag atatactaaa agctaacaaa gaaatctcat ctattacaaa
    33241 tagcattcct ggaggagtac aaaagtgtac cctgggtgaa acatgcaata ttaatttttt
    33301 aagtgatgga tttatagagt tgtttggtta tacaagagaa gaaataaaaa cattgtttaa
    33361 taatgatttt tatagtttaa tacataaaga tgatgttgaa agaataaaaa aagaaatttt
    33421 taaacaactt tacaaaaata aaactattga attagaatat aggattataa caaaaaatgg
    33481 taatacagta tgggttttag ataaagggga gcttataaca gaacctgatg gaaaagaata
    33541 tttttgttgt gtaactgtag atattactag aacaaaacaa ttagaacaag agatggaaca
    33601 aaaaaatcta gaacttgaaa tgatatcaga aaatgtttta ggtggtataa ttataacaga
    33661 atttaatgat gattttacta taaaatacgc taactctggt tatctttcaa tgattggata
    33721 tacacgtgaa caattagaaa atgaacttaa atacaaagct tgtaatcttg ttttttatga
    33781 ggataaaaag aaggctcttg aaagtataca acatcaatta aacacaaaag gaatagctgt
    33841 atatcaacat agaataagaa gaagaaatgg taatattatt tgggtttcta taaaaggaag
    33901 gcttattgtt gatgatgatg gtattgaaaa aggtatttgg attctaaatg atataacaga
    33961 tttaaaaaat gcagaacaaa aacttaaaat aaatgaagaa agatttagaa ttgcattaaa
    34021 gcaaacatca aacactatat ttgagtatga tataaaaaca aagtcacttt taaatactag
    34081 taaagagctt gataaatata atatttataa aattactaaa aacgttccat attctctagt
    34141 agaatcagga gttattcata aagattttag tgatgatttt ataaacatgt atgaaaatgt
    34201 aataaatgga gcaaaaaaag caagttgtgt agttaagatg aaacttccag atgaaaatta
    34261 tatatggaat aaagttacct tgactactat ttttgatgaa gatggtaatc ctgtaagagc
    34321 aattggtata caggaagata taagcaaaca aaaggaagca gagataagat acaatcaaga
    34381 aggtaagtat cattcagcta tattgtcgga agcaatgata acttatgaaa taaatgtatc
    34441 aaaggatact tttatcaaag gaaatgaaag ttggcaaaaa ccatttggaa ttaagcctga
    34501 caataactat tctcaaatgg taaaaactat agcaaatagt attgtacata aagacaataa
    34561 agaaacattt ttaaatacat ttttatgtga aaacttattg gatgcatata aaaataatgt
    34621 gactgaaata aaattagaat atcgaagaat gaatcaagaa aataaaatga tttgggtcat
    34681 ttgtacaatg cacttaataa aagattctat tacgaacgat ataaaagcac ttgcttatgt
    34741 taaagatatt gacaagcaaa aaaatgaaga aattagatta aaattaaaag ctgaaagaga
    34801 tactcttaca ggattatata ataaaggtac tacagaaaaa ttgattaatg atttcttgaa
    34861 ctctgaggaa gcaagtttag gaatgcatgc atttttaatt gttgatatag ataattttaa
    34921 atctgtgaat gataatttag gacatgtatt tggagataaa gtattatttg aagtttctaa
    34981 aaacctaaaa cctatattta gaaaagatga tatagtaggt agaattggcg gagatgaatt
    35041 tatagtattc ttaaaaaata ttcagtcttt tgagaatatc aaaaagaaag cagaaaaaat
    35101 atgcgatata tttagaaatt cttatacaga aaataaaaag acatataaaa tatctggaac
    35161 agttggaatt tcatttgtac cagaacatgg aactgtattt gaagaacttt ataaaaaagc
    35221 agacatagca ctttattatg caaagagcaa aggaaaagat aagtatgcac tttataatga
    35281 ttgtatctac caaaatgaac ttgaaaataa tataagtgat aataatataa aattagcaga
    35341 taaatgtgag aaatccaaac cagtacttaa agaaattctt gattctattg ataattatat
    35401 ctatatagtg aatccaaata cttatgaact tctttttatc aataataagg tgtctcgttt
    35461 ggatttagag ataaaattag gagaaacctg ttataaatca ctattaaaat ctgatagacc
    35521 atgtaataat tgccctctta acggattaga agaaaataag cattcaaaat tcaaaataga
    35581 gacaaataca tttggtaaaa atatcagtat agcaagttgg attaattgca tagatggaga
    35641 atacaactgt cttatagagt gtatagattc ttctttatac aaaaataaat aaaaaaggac
    35701 tatgaagata tgttaaatag tataactttg atacttggta taatatttac aatttactat
    35761 ttttatctca aaatagtttt tggaggaatt tcatttagtg agattttctt agttgtagga
    35821 attgtactaa ttatctatca aatatttaag aaaaaaatta aagaaaagaa ggttttttat
    35881 agggtgttaa aaataataat cagcattttt ttaatagtat ttgtagttac tgagagtcta
    35941 attatttttt atcccaaaaa tagtttagaa tcaaaaagtg attatctctt aattttagga
    36001 gcttctgtaa aaaagactac accaagtaca accctgaagg gtaggttaga cactgcattg
    36061 aaatacctaa aaattaatga taattgttat gtggtagtat ctggtggtaa aggaagtgga
    36121 gaaaaaataa ctgaggcaaa agctatgaaa gattatctta taaaaaatgg tatagataaa
    36181 aataggataa tagaagagga taaatccacg aatacttatg agaattttaa atattcaaaa
    36241 ttgaagatag aagaacatag tcaaggaaaa ctaagcgatt taaaagtaaa aatagtaaca
    36301 acagattttc atgttctcag aagtaaaata ttagcatata gaaatggata taaaaatacg
    36361 tctttttatg ctagtaaatc aaaactttca tttgtaccaa cttactatac aagagaattt
    36421 tttgcattat ggaaaacaat catttttgat agataataaa taaaaagact agatataaac
    36481 tcatatctag tcttttctat tcccttaatt ctaatccatt ttccaacttt acttgttgta
    36541 gaaatttcaa cattgggatt tacaagtaat tgcttataag aagttttata ttttacgatt
    36601 ccaaaatata attttccttc ataatccatt ataaatccga atggtcttac tcttggttta
    36661 ttatcttcaa ctgtagcaaa atagaatgtt gagttttctt taaaaaaatt cattattttt
    36721 tcatgattaa atcctctttg tatcttatac taatataatg aatataaata aaatattcat
    36781 aatactaata taaatcgata taaaaacaat tacaatatta tattgattat tcaaaattat
    36841 atataaaatt cagaaaaaaa ttttagttta cataataaaa ataaagtcaa ctaaaattat
    36901 tgattttaga ttaaagtacc ggattaagca tttaagtaga ttttaagctt gatttgatta
    36961 gaaaggtaca aactatcacc gaaaaaaatt aaacccattt aaaaagcaat ataaaagctt
    37021 gttatttttg agaaaaatag accctctaaa ctcaattaga ttaaaaataa aatacagaaa
    37081 attatatctc taaatatctt aaataattaa gtttaaattt tacgatattt tgtttgatga
    37141 tttataatat aaaagcatac tcttaatctt caaaatttaa aaagagtaaa aaataacaaa
    37201 aaaatcactg acatttcact gacaaattgt aattttgtta ttataaatac attgaaaata
    37261 cttgattatt gaaaaatggc ataaaataat acattttatg ccatttgcta ttatttgata
    37321 gtttttaact tatgacataa gatatttttt aacatataca ataaaatata aaaaaattga
    37381 tattgcaaat aaaaaaaaat acatattaga tgttatagaa aaaaagcgca cttataggct
    37441 taaaatgtca cataaaagag ttttaaagaa taatatatta tgaacacaaa ttttgtaatc
    37501 acaaaggagt gataatatgg caacagtatc aggacaaata gtttttgata gaaatagaag
    37561 tgctaccatt gattctggag actcaggaat agccaatata ccagttgtat tacaagatat
    37621 agcaactgga gttagacttg tggttctcac agatgcatca ggaaattatg tttttactaa
    37681 tgttccaaat ggtaactata gaattgtaga agcttttgga actacaggag gagtaccaac
    37741 accaggaaat tttgcaacag cgatagtagg tccagttcca attgcagaaa tgccacctat
    37801 tagttctgtg acaagtcctc ctattggttc aacaaactta gatggtacaa cacctaacac
    37861 actattaata acagtagcag gttcagatat aacaaatcaa aatatattaa atgggcctgt
    37921 gatttataca cctatagaga atatattgga ttcttgcgta tctgtatcta atataaacct
    37981 tattacagat gcagataacg gaacattcgg tttttttcca ccaggtacac caagtaatac
    38041 aggacctgaa atagaacctt acccaaatgt gacgccagat tttacgtatg ttgtaccaga
    38101 cccaactaag tttacacctt tagatggaga atatacagta caaaatatta tgacaaatgc
    38161 aatgagtaat gttataggag cttggtggcg tattgctgac catactacag gaaatgaaac
    38221 aggaagaatg atggtggtaa atggttttaa tcctggagct gtatttttta aatcaacagt
    38281 acaagttaca cctaacacta attatttatt tagcacttgg attttaaacc tttttaaggt
    38341 aacaggatat ccaccaccac agctaggtgt aagaatattt gaccaaaata ataatatact
    38401 atatcaagca acattaggag ctcaaattcc agttaataca aacgcaccag aatggaaaga
    38461 agtaggtact gtgattaatt ctcaaaataa taatcaactt acagtagaat tttttagtga
    38521 aggagaaagc gccattggaa atgactatgc tatagatgat gtttctttaa gagaaatagc
    38581 tgttccaact tttactccaa taaaaacaag taacacagaa actgctaatg taggtgatat
    38641 aatcacatat acagttacat tagataatac ttgtgatagc cctttaacta atgtattttt
    38701 tagggattta attccaaatg gtttagagtt tatacctgga actgtaacgg ttgatggagt
    38761 atctgtacca ggagtagacc ccaatacagg tttcccactt ccagatattg gaggaggaac
    38821 aggggttgaa gtaacttttg atgttgtggt tgaaagtatt cctaacccaa atcctactaa
    38881 taatatagct actatagatt actcctatac acctgtagaa ggcggtatac caaatgattt
    38941 ttcagtagat tctaatccag ttcctgttga agtaatctca gcagatattg aagttacaaa
    39001 attatctgaa cctactatag tgaatccagg agaggaatta atatacacta taaaagtagt
    39061 aaataatgga ccattcccat ctgaaaatgt ggttttaaca gatgatgtac cagcttctat
    39121 tgtaaatcca gagtattcat tagatggagg agtaactttt caaccatgga ctggaagttt
    39181 aaatataggg acattagaag taggagagac aagagttatt ataattaggg gtattgtaaa
    39241 tccatcaaca gtaggaatta taacaaatac agctgtggta tcttcaacta cagcagaccc
    39301 aaaccttaat aataatacat ctacaataga gacagaagtg aatttattag cagatatttt
    39361 agtaatgaaa acagcagaac ctaattcagc tgttccaggt actttattga gatatactat
    39421 tcaagtagaa aacttaggac cagcaaatgc tgaaaatgta atattaaatg atgatattcc
    39481 agcttctatt ataaatccag aatattcatt ggatggagga gcaagttttc aaccatggaa
    39541 tggaagtctt aatataggaa ctttaaactc tggaatttca ttaacagttt taattcaagg
    39601 aacagttagt ttaaattctt cagaatatat agtaaataca gcaacagttt cttcaactac
    39661 acctgaccca gatttaagca acaatatatc taccattatt acaccagtta acccacaagc
    39721 aggtatttct attataaaag tagctgacga ggatgtagct gttccaggag aagaatttgt
    39781 atatacaatt gaaattttta atgaaggacc atctaatgct acgaatgtag ttttaacaga
    39841 tgatatacca gatgttattt taaatccaga atattcattg gatggaggag caactttcca
    39901 accatggact ggaagtctta atataggtac agttgcacca gggcaattaa taagaattat
    39961 cataaaggga ttagtaagtt caactgctac aggagatatt actaatacag cagaagtaag
    40021 tgcagatgta ccagaaccag ttacggattc atcaacagtg acaactccta tagttccatc
    40081 agcagatata gaagtaataa aaactagcaa tatggataca gcagttccag gagaaacttt
    40141 cagttatact ataacagtta caaatttagg accatctgct gcacaaagta tcgttttgac
    40201 agatgatata ccagatgtta ttttaaatcc agagtattca ttggatggag gagtaacttt
    40261 ccaaccatgg aatggaaatc ttagtatagg cactttggat gctggagaaa taagaagtat
    40321 tataataaga ggaacagtga gccagacagc agtaggtaca attataaata cagcaacaat
    40381 aagttcacct acacctgacc caaatccaga taataatact tcaacagatg aaacagatat
    40441 aagtccatta gcagatattt ctgtgataaa aggcaacgaa ccagttgcta taccaggggg
    40501 aagatttatt tatggaattg aaattgcaaa tgcaggacca tcttttacag agaacgtaac
    40561 tttaacagat aatataccag cttctatttt aaatccagag tactcaatag ataatggagt
    40621 gactttccaa ccatggaatg gaagccttaa tataggtact ttagatgctg gagagataag
    40681 aaatatcata ataaggggaa cagtaagtca aacagcaata ggcacaatta taaatacagc
    40741 aacagtaagt tcaactacac ctgacccaaa tctaaataac aatacttcaa catcagaagc
    40801 agaggtaagt tcatcagcag atatttctgt agtaaaacga agcaatcaga ttgttgttgt
    40861 accaggagat gtactagact atacaattga ggtgagaaat gcaggaccgt ctactactca
    40921 gaacgtaact ttaacagata atataccagc ttctatttta agtccagaat attcaataga
    40981 taatggagtg acttttcaac catggaatgg aagtcttagt ataggcactt tagatgctgg
    41041 agagataaga aatattataa taaggggaat agtaagtcaa acagcaatag gtacaattat
    41101 aaatacagca acagtaagtt caactacacc tgacccaaat ccagataata atacttcaac
    41161 atcagaaata gatataagtt catcagcaga tatttctgta ataaaattag caaataaaac
    41221 agaagcatgt gtaggagagc aaatagattt tgtaatagta gtatcaaatg caggaccaga
    41281 aaatgctcaa aatgttactt taatagacaa tgtttcagat aagcttaaga aagcagtatt
    41341 ttcacttgat agaggtgtaa gtttccaacc atggactgga agtcttaata taggtacact
    41401 accagctgga actttaagag ttattctatt aagaggaatt ataaaatcaa catgtcttga
    41461 tagattaaca aatattgcag aaattacttc aacaacacca gattcaaacc ttaacaataa
    41521 tatatcaaga gtgcaagtag aaataaaaca atgttgttgt aatgattgct gttgtaacaa
    41581 ctgtagtaat tgttgttgca atgattgtgg ttgtaaagat tgttgctgta attgttgtaa
    41641 aaatgacttt tggtgttgat tttataaaat aattttgtat accttaaatt aaactgaaat
    41701 aaaaaataaa ttcacatatg agtaaaatat tttataaata ttaataaatt ttctatcttt
    41761 gatatggacc acattcgtaa tactagttat taaatgaagt ggtccttttt aattcattaa
    41821 aattatttat tctaattaaa ttttaaatgt attaaata
//
LOCUS       DAEQCW010000024        41791 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.024, whole genome shotgun sequence.
ACCESSION   DAEQCW010000024 DAEQCW010000000
VERSION     DAEQCW010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 41791)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 41791)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..41791
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.024"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            215..1309
                     /locus_tag="KRO40_001285"
     CDS             215..1309
                     /locus_tag="KRO40_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092107.1"
                     /translation="MSEKVNVKTVISFAGAYVATVIGSGFATGQEIMQFFSFYGFAGI
                     IGGIISMVLFSWMGASVMSKGKELQLKEPIKIYRVYCGKYLGIFFEWFGPLFLFGVFV
                     VMISGAGATLTEYYGLNPFVGRVGMAVVALLTVSLGLDKLSKILGGIGPIIIIFTLLV
                     GGISLAKNIGNIGEAAQVLSTVKIAKPVPNAYLSGVIYTTYNTIVVMAFLTGLGASAA
                     NKKEAICGGILGGVALMAAAIMMHLAILSDIGNLYSKAIPSLFLADKISPVIGVLFSI
                     ILILGIYTTAVPLLWSVTNRFVDDKHPKFKLITLIAAILGLIGGFLPFDKLVGILYPY
                     TGYMGVIILVCVLYRQITKTSGYQEGISDK"
     gene            1535..1951
                     /locus_tag="KRO40_001286"
     CDS             1535..1951
                     /locus_tag="KRO40_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092108.1"
                     /translation="MNVKFNIKGIIYGVIALVFVIGGFIFIPSMFVEKSKPIDYTVLQ
                     RNSIPEKILDVMDKYTNEERALAAKIDNKIYIIVTRGNNKYGIEMDKIESVVEEGKDV
                     LRVKIKYKDKEDSFPYIVVETNMSELPDRIELNATK"
     gene            complement(2133..2702)
                     /locus_tag="KRO40_001287"
     CDS             complement(2133..2702)
                     /locus_tag="KRO40_001287"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HBH2092109.1"
                     /translation="MKKEFRKKVIESRKNKSANFVLSNSNLITEKLLQMEDIRNATNI
                     MLYLNFNNEVQTDNLIKKLLSLKKIVSSPITIKENHTLIPTQITDLKEGLRIGAYGIR
                     EPNEKSPTIDIKALDVVIVPAVAYDIHCYRLGYGGGFYDRFLENLRKDAITIGIAFDF
                     QIFDSIPKETHDAQLDYIVTETRIITPNS"
     gene            2856..4013
                     /locus_tag="KRO40_001288"
     CDS             2856..4013
                     /locus_tag="KRO40_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S41 family peptidase"
                     /protein_id="HBH2092110.1"
                     /translation="MYLVISKKKAIFLGVILVIITAMVTSAFQLTLGNKVVISKELYE
                     DYKKYDKLLGLESIIKQDFYKKVSDTDLVNGAAKGLFLGTNDKYSGYYTKDEMENLIN
                     DSEGSYVGVGMYIGASKDGGLVVVPMKDSPAEKAGVKSGDKLVKVNGKSVSYKNSDEA
                     VRMMKGKKGKTVELTILREDKQLNFKVKTDQIIEKSIESKVIDNDLGYIEITQFISST
                     YTDFDKALKELKAKNIKGLVIDLRNNPGGMLDICKEVADELIGEGTIVYTKDNKGNTE
                     YLKSDKEKLGLPIVVLTNGESASAAEILTAAIVDNKEGISVGTTTFGKGLVQSVVRLK
                     DGTGYKLTTAQYFTPNGDYINEKGIKPTIEEKDENKQLDVATKWLREQIDK"
     gene            complement(4196..5350)
                     /gene="nagA"
                     /locus_tag="KRO40_001289"
     CDS             complement(4196..5350)
                     /gene="nagA"
                     /locus_tag="KRO40_001289"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBH2092111.1"
                     /translation="MKSFIYADKFFMKHGIKEKGYLSIINGKFGEFQQERPNNTDNVI
                     DFSGKYIAPGLVDTHIHGLLGADVMDNTFEAINTISKGLLKYGVTSFLPTTLTDSVDT
                     LSDSVENISNSFNRVEGAKIQGIYLEGPFFTEKYKGAQNEKYFKDPDINILKLWQKKS
                     KNLIRKIAIAPERKGSIELTRYATKNNISVSLGHSSATFEQVKQVVNSGAKVFVHTYN
                     GMSPLNHREPGMVGAAMVLKDTYAELICDGHHVSPIAVKIMMDAKSSNNIALITDCMR
                     AGAMEDGKYTLGKFNVNVKNSVARLNSGSLAGSVLTMDKAVRNIVDWNISTLEDAIKM
                     ATYIPALSCNIDNVCGSIYQGMDADFIVTDNDFNIHETYINGICMYKVNK"
     gene            complement(5433..6158)
                     /locus_tag="KRO40_001290"
     CDS             complement(5433..6158)
                     /locus_tag="KRO40_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2092112.1"
                     /translation="MIKRNDKRPIYDQLVEILRTKIENEMEPNDRMLSERKICDEYGV
                     SRTTVRLAMAELEHMGYIYKRHGKGTFVAALSQNSQNLMESYSFTDYMRTQGKKPGTK
                     VLSFEVVESTKYFSEKLGITTGEKMIKIMRLRLADDLPMMLERTYLPMKEFIGLTKEK
                     IEQKPLYEIFREDYGEIIKVADEEFSAGIISDKEAKLLEVPGDSPCLKLLRTTYNDDN
                     IVIEFTLSVARSDKFVYRVRHVR"
     gene            6425..7354
                     /gene="pfkB"
                     /locus_tag="KRO40_001291"
     CDS             6425..7354
                     /gene="pfkB"
                     /locus_tag="KRO40_001291"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBH2092113.1"
                     /translation="MITVITFNPSIDRMYRVNNINIGEVQRVVSKNATAGGKGLNVAK
                     VCKILKENPLAMGFLGGFNGEFIKNELRKLDIQNKFTKIEQETRNCLNIIEDNKVSTE
                     FLEKGPIVEKSDLERFENDIEEVLKNTKILVASGSYCENMPIDYYEKIGNTCRANNIK
                     FILDTSGEALKIALKSKPYLIKPNIDEIRHLLGMNIESREEIILSGKKLIEMGAENVC
                     ISLGKDGMVYLNEDNVYDVKVPVVKCINTVGSGDSTVAGFSVGILRGYKIENLLKFAN
                     ACGISNALNMETGFVDLGEIDKYQDLVEVKKLS"
     gene            complement(7483..8400)
                     /locus_tag="KRO40_001292"
     CDS             complement(7483..8400)
                     /locus_tag="KRO40_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH2092114.1"
                     /translation="MKNIKMGMIGLGSIAQKAYLPILTKSERFEFVGAFTPNKVKREK
                     VCSDYRIMPFDSIESLAKKCDCIFLHSSTETHYEIIKILLNLGVHVYVDKPLASTVSQ
                     GEELIELSTKKNLNLMVGFNRRFCPMYKEIKNNATEIVSINICKHGLNSLRNVRFDST
                     LIDDYIHVIDTALWLANEDVEISGEDLFLTDNKNLIFVSHKLKGKNFSINTSMHRDSG
                     TKLEQVEILSKGKIQRVKNLNVLEIEEGGNLTLKQSGAWVNILKQKGFEDISNHFIDC
                     IENNIKPAINGEECIKAQRLLEKIINSVK"
     gene            8871..10040
                     /locus_tag="KRO40_001293"
     CDS             8871..10040
                     /locus_tag="KRO40_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH2092115.1"
                     /translation="MKMFKLEEQKLKDLGAIITTNEIKQQPELWLETYEIYKSNKEKL
                     SRFIDTISNNHGQFRVIFTGAGTSAYIGNSILPYLKNKNDIRKYIFEAIPTTDIVSNP
                     YDYLKKDIPTLLISFARSGNSPESLAALNLGNKIVDNFYHLAITCNPEGELAKMTKND
                     ENNYLLLMPSKSNDEGFAMTGSFSCMMLSAMLIFDSLEDDVEKSYINAIIEMGRNVID
                     RKDEIHELINKDFDRVVYLGSGGLGGLTQEAQLKLLELTAGKISTVYDSPMGFRHGPK
                     SFIDENTLVFEFVSNCLYTRKYDLDVLEEIKRDKIAKFTCAVSVENENNFSGTKFEFK
                     EKYNKLPDVYLAMPYILFAQTIALFVSVKVGNKPDTPSATGTVNRVVKGVTIYEY"
     gene            10089..10940
                     /locus_tag="KRO40_001294"
     CDS             10089..10940
                     /locus_tag="KRO40_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBH2092116.1"
                     /translation="MALVTTTSMLKKAQDEGYAVGAFNVENMEMVIAVIEAAEELNSP
                     VILQTTPSTVKYAGLDYYLANAKVAAERVNIPVAMHLDHGSSFDLAMKALRSGYTSIM
                     IDGSHESFENNISISKSVVKACSPSLIPVEAELGKVGGKEDDLDGGNSNDYTNPKEAK
                     EFVDRTGISSLAIAIGTAHGLYKGEPKIDLDRLSEIKNVVSIPLVLHGGSGIHDDIIK
                     EAIKRGIAKVNYATELRIAYSKGVKKVLDEDSEVIDPKKYGLAGLQSVKDFVKEKIKV
                     CGSVNRV"
     gene            11266..13167
                     /locus_tag="KRO40_001295"
     CDS             11266..13167
                     /locus_tag="KRO40_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2092117.1"
                     /translation="MRERIILETLKNSSGYLNIDYFADKLGVSTRTIRNEIKKIETIK
                     ECNGFKLEYKSKLGYILNIKDQDKFEHYLRNLPSDLVENPEQRLESIIVELLVNEGYK
                     TIEQLSKKFLVSSSQIKNDLKKIDEKIKDTELKLERKAHYGIKIEGSIKEIQSILVDS
                     YFRGNRNITEYRNKFIDNLKLANIRSTIKNVLNEHDLEANLTELEEILAQIIILYIRV
                     SMRVVGNASDLKLYTEDLIIDKLLDKIFRDKKYNLNYDEKYYLKELIKLKTKDKKATI
                     KNIDKNKLQDIMFEFFREIDKKYNSNFLEDKEFFNLFYLHIACLIERIKKNHKIINPF
                     SVKISQQYPTVFNLSIQFSKIIENEYHIKISQDEIGFIATHIAVPFEKREEANFNKKY
                     KIAIICSSGGGSAFLINLRLKEIFPNAEIRNFSLLEEKAVIEFAPDLIFSITNLLFEI
                     NAPVILINEILDELDYLDIKESVRFADHIGNISSPKQYILGLFDKNHFRCIKDKAKYK
                     DILDSMSKCIVDEGACSPTYPKDVWERESYLSTIYTNGVAIPHPIEMTGNKNIISVAL
                     IQTDIIYENRVPKIIFMISLIKGNLELHKQISKYLSKIMANKDMVDMLNKSQSYEEFM
                     YKLKIYLGG"
     gene            13170..14213
                     /gene="ypdE"
                     /locus_tag="KRO40_001296"
     CDS             13170..14213
                     /gene="ypdE"
                     /locus_tag="KRO40_001296"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH2092118.1"
                     /translation="MNIEFFKRLSEADGIASNEEEVRHVLLEELKAYSDKIICDGLGS
                     IIFSKIKDESAPNVMICAHMDEVGFMVRSIDKLGMIHLITIGGVKPLAQFVQKVRITT
                     KEGKKIPAVINATYNNGKAENIYADIGAYTEEDVYNLGINVGDMVTYTTSFEEFTLPD
                     RLVGKAFDDRIGCFVMGEVLKELRKENLNCNIHFAATSSEEVGIRGAKTSTQLINPDI
                     VFVIDVACAKNEFVRDYTNKKQIDKGVMLMHRDRTLVPSRKMIDYVMEIADKNNIPLQ
                     HDMFESGGTDGGEAHLVNEGKPCVVTCVPVRYGHCAFSIVSNKDLENIIRLYTQLILN
                     FDEEQYKHIRNFI"
     gene            14228..14533
                     /locus_tag="KRO40_001297"
     CDS             14228..14533
                     /locus_tag="KRO40_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2092119.1"
                     /translation="MSTEVQIMELISTAGESKSKAFEALKKVKSKDFKGAKLLIEEAR
                     KIDIEAHRIQTELITQDLNEDVESPAMSLLMVHAQDHYMTSQLAKDLIEALIYCLDK"
     gene            14630..14965
                     /locus_tag="KRO40_001298"
     CDS             14630..14965
                     /locus_tag="KRO40_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092120.1"
                     /translation="MKILLCCAGGFSTNMLMQNMKKVVKESAKLNEKDFEFTAIPADS
                     IESEVDDWDIVLIGPQIAHKIDFLKGILEPKNKPFAVIDKDVYGKMDGATVMKLALIT
                     YKKHQLAQG"
     gene            14997..16319
                     /locus_tag="KRO40_001299"
     CDS             14997..16319
                     /locus_tag="KRO40_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2092121.1"
                     /translation="MFSKFEAFMNRVFMPLAHKVDNQRHLGSIKAGMVAMTPFTILGS
                     IFAILPALPNMLGENNPISKFILSNSAILDLPVSLSIGLIGLYACMCIAFNLGNYYKL
                     YIPGCVALSTFSFLFLVASFTPDGALEIGNLGAKGLFTGMIAGLGSVELYNFCNKKNI
                     TIKMPENVPDFVSRSFELIPTTIIVCGTFIVARFISLKVFGELPPQILTQFLSPLVGS
                     MDNPWSVLALNFAICTIFFFGIHSSVFSPITRPIMITFIAENIAAMQAGETIPHFFTA
                     GASSAFFGFTGCGISIGCVIACMLSKNASYKKIGRVSLFPALFGINEPILFGAPIILN
                     PIMFIPHVFGGAIIGTLPMFFMHWGWLAKPVFDPPYVGVFLEGFLTNGDWHSILANAL
                     QLVLAVLLYWPFFKIMERQQNNKKQKEETKNIFSKEEEDLLDDLGLDF"
     gene            16329..17399
                     /locus_tag="KRO40_001300"
     CDS             16329..17399
                     /locus_tag="KRO40_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2092122.1"
                     /translation="MNNTMERLVSLIYKRGVDALLIKAKNTKRYIGALSGSGVYVLVT
                     KDKNYQILDGRYIDEADKKTTGFIKRIVSQGSYIPTIIELLKELNIKKLAIENQAMSI
                     QEYLSLKNEGFEINLITNELWKLRAIKSKEEIKLIKKACEITDEVFDEVISEIKKDMT
                     ELEVSALIQYHALKKGASGMSFETIVVSGERGAMPHGRPTNKKLKVNEAITIDFGVVY
                     QGYQSDMTRTISIGKPPKIIKEIYDVVLEAQLSAIESIKEGTRASDVDKVARKIIDKH
                     GFGEYFNHGLGHGIGLGDGEVPTLNPNSEDILVEGMVMSCEPGIYIPNVGGVRIEDDI
                     VIIDGKGVPLNKTSKEFIILGE"
     gene            17404..18591
                     /locus_tag="KRO40_001301"
     CDS             17404..18591
                     /locus_tag="KRO40_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2092123.1"
                     /translation="MKYNFNKVLNRKEGNCRKWSNHVIKEKFGLNEDAIPMDLADIDF
                     ECAPAIKESILKRASVGDYSYTFIGDDFYDAIINWNKRRFDVYIEKDWIKLTFGTVST
                     LHYIVQAYTKEGEGVLINTPAYDPFAEAVVNNNRKLCCSSLKLDNNRYYLDLEDMENQ
                     MKYENIRLLIFCSPQNPSGRIWTKEELYQVSELCLKYNVILVSDEIHRDIIFKDYRFV
                     SLWNAHPEIYKNSIICVSPNKGFNLGGLKTSYVLIRDVKIRETLLERLKSNSITSPNV
                     FAIPAIVAAYNESEEWLDAMTSYVEENFEIVYDFFETNIPKAKVMKSDSSFLAWIDVR
                     EVFRNEEESKEFFRHANLTMVVGSYFVKDGDGFIRINVGCPRETLNEALNRIKKTYIS
                     MYC"
     gene            complement(18788..19660)
                     /locus_tag="KRO40_001302"
     CDS             complement(18788..19660)
                     /locus_tag="KRO40_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose 1-epimerase family protein"
                     /protein_id="HBH2092124.1"
                     /translation="MNILQNENLIIESSSFGAELTKIFSKKYDKNILWDGNKKYWGRQ
                     SPILFPIVGKLFDNETIIEENLYSMTQHGFARDMDFEIVDKGDTFVTYKLTDNESTLK
                     KYPYSFELIINYTLNDNSIEVEWIVKNTDSKDIFFSIGGHPAFNLPFYEQNDFSKHYL
                     EFKSKNDVEKINLNGSFTDDIIPIGKLKNLQLNPEVFKNDALIYTNIDEVSICNNDGS
                     KYVTISMEDFPLVGIWTPYYSETNSTAPFLCIEPWYGLADSINSNKIYKDKKFINKLS
                     KGKVFTASYNINIH"
     gene            complement(20054..20245)
                     /locus_tag="KRO40_001303"
     CDS             complement(20054..20245)
                     /locus_tag="KRO40_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092125.1"
                     /translation="MDDFSKLKSLYEDGYRCIYHDCVDNNYTIYLKNFYTEGSETIEL
                     SSESDFSQFKDYIDGLRMS"
     gene            20465..21511
                     /gene="cobT"
                     /locus_tag="KRO40_001304"
     CDS             20465..21511
                     /gene="cobT"
                     /locus_tag="KRO40_001304"
                     /EC_number="2.4.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide--dimethylbenzimidazole
                     phosphoribosyltransferase"
                     /protein_id="HBH2092126.1"
                     /translation="MSLLESISKNIYSLDNSSIEKTKQRLDRLIHPTGSLGKIEDICM
                     QLAGIFGNENFDTSKKVIIAFAGDHGVYEEGVAPDPQNITKLQFPNFSKGLCGVGVIS
                     KFVGADVVAVDVGINCDEKLDGVLDYKIRKGTSNMAKGPAMSKQEAIRCLEIGIEIAE
                     QCIEKDYKVIGIGEMGIANTTPSTAIISVISGCDPLEVTGIGAGLKKERLKHKAEVIR
                     KAIEINNPNPTDGVDILSKVGGFEIGSMAGVILGCSANRIPVVIDGFISYAAALIAYK
                     INPKTREYMIASHLSAESGTKRALDILKLDPLLNMDMRLGEGSGAALAFDIIEASNYT
                     YKNMATFDEIDMGR"
     gene            21543..22103
                     /gene="cobU"
                     /locus_tag="KRO40_001305"
     CDS             21543..22103
                     /gene="cobU"
                     /locus_tag="KRO40_001305"
                     /EC_number="2.7.1.156"
                     /EC_number="2.7.7.62"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional adenosylcobinamide
                     kinase/adenosylcobinamide-phosphate guanylyltransferase"
                     /protein_id="HBH2092127.1"
                     /translation="MSKIILVTGGARSGKSNFAEKLCFDRNNNTAYIATSIPFDDEMK
                     DRVKKHQENRPRNWNTYEIYEDIYSIIKEIYKEHETVILDCVTLLVNNLMFEHNLNIE
                     ESSQEEINKLEQYIKEQVVKLIEEIEKTNLYFVFVTNELGMGIVPGNKLSRIYADIVG
                     RINQYIASKSNEVYFVVSGIAMKIKE"
     gene            22113..22886
                     /gene="cobS"
                     /locus_tag="KRO40_001306"
     CDS             22113..22886
                     /gene="cobS"
                     /locus_tag="KRO40_001306"
                     /EC_number="2.7.8.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobinamide-GDP ribazoletransferase"
                     /protein_id="HBH2092128.1"
                     /translation="MKRFILILQFLTRIPIKLNVGFDDEFYKSIVYFPLVGFVIGILS
                     YLIGWISMLLFEPFIASIIITLAGVLITGGLHIDGLGDTFDAIYSYRDKEKMLEIMKD
                     SRLGTNSLLAIMFVLLLKVGFVYDIISNNSLWVIIFMPMIARLGVMLLTYKTVTPREK
                     GMGNLFIGKLTTSMLITAIIYTLLIVALITKFIFLLPNIVLIKVLGSIIVVFVFIILF
                     KKHIYKKIDGVTGDILGCGIELSELVYLIYIYLLIFMFF"
     gene            22906..23520
                     /locus_tag="KRO40_001307"
     CDS             22906..23520
                     /locus_tag="KRO40_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBH2092129.1"
                     /translation="MIRLILIRHALTNDNKKGRLSGHINSCISEEGKLQINKITRYLS
                     NENIDKVYTTPSTRTKDTVEKISKLKLLEIEEKEALREISFGDFEGRTFEEIKIKYPN
                     EFEKMIKEGNNYRYPNGESLIDSYKRVAKEIDNIILENNSNLDTKTILICSHAGTIRN
                     IITHLISGSYKYHWNFKIDNASITVLEIDGGFAVIDKMNFTDFI"
     regulatory      23587..23766
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            23896..25395
                     /locus_tag="KRO40_001308"
     CDS             23896..25395
                     /locus_tag="KRO40_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyric acid synthase"
                     /protein_id="HBH2092130.1"
                     /translation="MLQGTASNVGKSVLVAGLCRIFKQDGYTVAPFKSQNMALNSFIT
                     KEGLEMGRAQVFQAEAAKIEPIADMNPVLLKPSGNNKSQVIVRGKVVGEMPSSKYHDY
                     KLELVDVLKETFNSLNSRYDIVVMEGAGSNAEINLKDRDISNMGMAEIADAPVIIVGD
                     IDRGGVFASLAGTMLLLNEDEKRRVKGVIINKFRGKKELLQDGVKMLEDIIKVPVIGV
                     VPYTDIKIEDEDSVTTRFKKKMNKSDIHIEIIRTPHMSNFTDFNIFETQEDVSIRYVD
                     YGESLGNPDILIIPGTKSTIDDLTYIRKSGLESQIKNLHSQGKLIFGICGGYQMLGKK
                     LKDPYHVESEIEEVDGIGLLDTETTFEKEKTTTQVEATIVECISEYMNNLKGKKVKGY
                     EIHMGITKRGNDVRSLDLITKKLDKEVNYTEGSVNKEGNVIGTYLHGIFDEISFTRAI
                     LNNIRKKKGLGELESKVNSFNEFKDKEYDKLADFLREHLDIEKIYEIMK"
     gene            25434..26810
                     /locus_tag="KRO40_001309"
     CDS             25434..26810
                     /locus_tag="KRO40_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyrinate a,c-diamide synthase"
                     /protein_id="HBH2092131.1"
                     /translation="MKKILIAGTNSGVGKTTISLGIMQALVKRNMKVQPYKVGPDYID
                     PSYHTFITGRHSRNLDSYMLDDEKIKYIVNKSSKDADISVIEGVMGLYDGFGIDLDNC
                     TSSHTSKVLKSPVILVINGKSMAASSAAMVLGYKELDKDVNIKGVIVNNVKTNSHYQI
                     IKSSIEKYCNVEVLGYFPPNNKFSLESRHLGLVPSVEMKSLREKFYTLADEIEHYIDI
                     DRIIEISESDEFESDFDFQTLIENNKIKEHVNNKSIAIAYDKAFNFYYRENIELLEEL
                     GLEINYFSPLEDASVPNADYIYIGGGFPEIFGKELEANESMRTSILEAHNNNIPIYAE
                     CGGLMYLGEKLLNQEEQEFNMVGIFSGISKMTSSLKRFGYCIGVAKENTLLSKKGESI
                     KGHEFHHSIFESDEKCVYSMRKERDGNIVEEWDGGYSKGNTLATYLHTHFYNNLNCIE
                     NFLKKGNE"
     gene            26811..27782
                     /locus_tag="KRO40_001310"
     CDS             26811..27782
                     /locus_tag="KRO40_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBH2092132.1"
                     /translation="MSILSIYIGYVTDLIVGDPYSFPHPVRFIGKLINFTQCIIRKVS
                     KNDRQLKFGGFILWLITVGITYLTTYAIVKLFSFNILLSIVVNSFIIYTTLATKCLKD
                     EALKIYNVLKTEDIEKSRIQLSYIVGRDTTNLSEPEIIRATVETVAENTVDGIIAPMF
                     YAFIGGAPLAMAYKAINTLDSTVGYKNKKYKDIGFASAKIDDIANYIPARISVILMTI
                     GSFFLNYNYRNCFKISIRDRKNHKSPNCAFSEGAVSGALGIQLGGTNVYFGEKVYKPT
                     IGDKLREIDKEDIIKTNKIMYASSFVSMLVFTLIYVLCRMILINLII"
     gene            27814..28884
                     /locus_tag="KRO40_001311"
     CDS             27814..28884
                     /locus_tag="KRO40_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2092133.1"
                     /translation="MKDLGHGANVDEMARLYGKNPKEIIDFSSNINPNVLPNLERYIL
                     KGLEECRNYPDINYTNLRENISKYIDINPDFIIPGNGATEVIYLLMKSIKKKLAIINP
                     TFSEYRRSAELNNLDIIDLELDLENNFKLNIDIIKENIKRFDSLFICNPNNPSGNVQD
                     LKELVHLLDKHNKVLIIDETFMEFVEDESKYSLVKYIESNKNIFIIKAVTKFFGMPGL
                     RLGYGLTSNTEIMNKIYEHKEPWTINSFADILSNFIFEDKEYIKNSKEYYIEERKYML
                     QELRNIRNIKVYDTDANFILIRIYKKTTKELKKDLFKQGNILVRDASNFIGLDDSFIR
                     VAIKSHEDNKILIENMKNLLGD"
     gene            28886..29773
                     /locus_tag="KRO40_001312"
     CDS             28886..29773
                     /locus_tag="KRO40_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBH2092134.1"
                     /translation="MKSYGICPASCGEFVQGIIDDEEYLCSYAIDMYSKVYIEEKLVD
                     INLGRYKSRLAIEKVFEKFNLPKKYTKNISLNINSKIPVGKGMASSTADIGATIKATL
                     SLIDKDLSSEEISKLAAEIEPTDSIFIDKNSIFNPLNGTVIKYLGNLTNAKVVILEPN
                     KVLDTMKIRLRQDYNKLKVENKEVIKKSFALLEEGLKKNNLSLVGEACTLSSLANENI
                     EKKECLNEIIKISKKYGAYGVNIAHSGTVVGILIDKSMNDKKMIDALCESNINSVYNK
                     IYTQNIINGGIKGEIEWNT"
     gene            29761..30393
                     /locus_tag="KRO40_001313"
     CDS             29761..30393
                     /locus_tag="KRO40_001313"
                     /EC_number="5.4.99.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003724727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-8 methylmutase"
                     /protein_id="HBH2092135.1"
                     /translation="MEYIKNPMKIEEKSFELIQEIIDEIRPDYKFKNNIEEKIIKRAI
                     HTTADFDYLDILKISEEAVDSIIDALKNNASIYTDTNMALSGINKRKLESLGCKYKCL
                     VADDETVKLAKEKGITRSMAAVEIAAKEEGRKIFVLGNAPTALYKVMEMKSEGRLDLD
                     AVIGVPVGFVGAQESKDEVEKTDIPYIISKGRKGGSNLAAAIVNAILYTM"
     gene            30402..31628
                     /locus_tag="KRO40_001314"
     CDS             30402..31628
                     /locus_tag="KRO40_001314"
                     /EC_number="2.1.1.195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase"
                     /protein_id="HBH2092136.1"
                     /translation="MEEYVYIDGKKYRRGYTTGSCATGASKAAVYMLITKNRINTINI
                     DTPKGIPLLLKVDNINISDTFVECSIKKDGGDDIDATHTMDIYARAEIVAKNDKNKGY
                     LTLKDIDSLSTNSECKSELYKFIRVYGGTGIGVVTKKGLSVDVGKPAINPTPLKMINH
                     EIRKLIGDNFESILGNDKVLKITIFAPQGETVAKKTFNPRLGIVGGISIIGTTGIVEP
                     MSDEGWKKSLSIELQMKKEQGLDKIILVPGNHGEQFIREKLNLDIKYVVRVSNFIGYM
                     IKEAQRIGYKKILMAGHIGKFIKVSAGIFNTHSKVADARSEILVANLALMGARYEFLN
                     KINQCVTTEEAVELINNSEYREVYNILSNKCRERVKQYLNEDSDDIDVEVIIFSMDKS
                     LLGKSDNTDDLVEVFI"
     gene            31625..32233
                     /locus_tag="KRO40_001315"
     CDS             31625..32233
                     /locus_tag="KRO40_001315"
                     /EC_number="2.1.1.289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-7 (C(5))-methyltransferase"
                     /protein_id="HBH2092137.1"
                     /translation="MINIIGLGPGNLDYITKKGENLISTSDVLIGGKRNLESIKNFEG
                     EKIVLDSNLREIIEYINNNKEKQISIIASGDPLIYGIGRYLSKNIDNKMLNMVSGISS
                     LQYIFSKIYVDMNDVYITSSHGKVPDFDYILSHKKVCMVTDSKIGPKQISREIIDRNL
                     NKIIVVGENLSYDNEKITIAKPEEIIRIDNFDMNVVVILDEE"
     gene            32223..32798
                     /locus_tag="KRO40_001316"
     CDS             32223..32798
                     /locus_tag="KRO40_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decarboxylating cobalt-precorrin-6B
                     (C(15))-methyltransferase"
                     /protein_id="HBH2092138.1"
                     /translation="MRNSEFITGKVPITKEEVRAISISKLNLVNAKNLIDIGAGTGSV
                     SVEAAYNYPNLKVISIEKNDDAIELIEKNIKKFNLKNIEVIKGCAPINLGLNVKVESI
                     FLGGTGNNLEEIIEWSKKNLVTGGRLVANFIIIDTFNQTLKLLKKHGFKEIDVCVLNV
                     SKLEKLGKGEYFKPLNPIYIISCEKGENDDE"
     gene            32791..33543
                     /locus_tag="KRO40_001317"
     CDS             32791..33543
                     /locus_tag="KRO40_001317"
                     /EC_number="2.1.1.271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-4 methyltransferase"
                     /protein_id="HBH2092139.1"
                     /translation="MNKVHFVGAGPGDKELITLKGYKLLSNADVVIYAGSLVNPELLE
                     YCKEDCQIHNSAHMDLQEIIDVMREGIENNKSVVRLQTGDFSIYGSIREQVEDLNKLN
                     IDYDCTPGVSSFLGAASSLGVEYTVPEISQSVIITRMEGRTPVPEKESIQSYAKHQTS
                     MVIFLSVQEIEKVVSKLLEGGYPKDTPIAVIYKATWADEKIVKGTLSDIAVKVKENNI
                     NKTALIMVGRFLGEEYNNSKLYDKDFKHEYRG"
     gene            33527..34648
                     /gene="cbiG"
                     /locus_tag="KRO40_001318"
     CDS             33527..34648
                     /gene="cbiG"
                     /locus_tag="KRO40_001318"
                     /EC_number="3.7.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin 5A hydrolase"
                     /protein_id="HBH2092140.1"
                     /translation="MNIEGNIAIICITENGKKLALKINSLVNNCVIYQVKNKKSNLVV
                     EETCVHTVQKKLSDFVGEIFSKFDYIVFIMATGIVVRSIAPYIISKFSDPAILVMDEK
                     GKNVISLLSGHIGGANSLTQYISSLIDANPVITTATDINQKASLDMIAKKLNAHIDNF
                     RESVKEVNSMLVNNKCVGLYVDEGYQVDTRGFKLIESKDELRDSFSNTYIEKLVVVSN
                     KINCIEDIENLNLDNKFEHCYSTQKIIKVIPRDIVIGIGCRRNTDSELMYNSLEEFLN
                     KQNIDIRAINTVGSIELKKDEKAIIELSKILKVPFKTFSVDEISKVDNLFDKSDFVKK
                     NVGVYSVAEPVAYLLSKGNLLVEKHKYKGITFSVGRIKI"
     gene            34645..35370
                     /gene="cobJ"
                     /locus_tag="KRO40_001319"
     CDS             34645..35370
                     /gene="cobJ"
                     /locus_tag="KRO40_001319"
                     /EC_number="2.1.1.131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011701973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-3B C(17)-methyltransferase"
                     /protein_id="HBH2092141.1"
                     /translation="MIYVVGIGPGSKDTMTLEAIKAIEDSEAIVGYKTYIKLIEEFIQ
                     GKEIIQNGMRQEVDRCKQAVEEAKKGKKVAVVSSGDAGIYGMAGLILELISKEDEDIK
                     VKVIPGVTASIGAAAILGAPIMHDFCHISLSDLMTPWEVIEKRLRLAAEADFVICLYN
                     PRSKGRSEHLSKAFKIMGEFKGGDTPVGVVKDVGREKEEKFVCTFENMDFEKVDMTTM
                     VIIGNKSTYINGELMITPRGYTV"
     gene            35367..36119
                     /gene="cobK"
                     /locus_tag="KRO40_001320"
     CDS             35367..36119
                     /gene="cobK"
                     /locus_tag="KRO40_001320"
                     /EC_number="1.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-6A reductase"
                     /protein_id="HBH2092142.1"
                     /translation="MILILGGTSDSLSICDKINELKNQPYILSVTTDYGRELAQQHAE
                     NVILGKLGKEDMLKFIKDNNIVKIIDATHPYAVEVSKTAITCAKLLNIDYIRFERKSL
                     IEEIDYDNKFIVDTIEEACEIANKIGTNIFIGTGSKNLNRFIEEISDKNLVVRVLPTS
                     EVILSCEKLGLSADNIVAMKGPFSQYINEETYKHYNIDLVITKESGIAGGFLEKVNAC
                     KTFNIPVIIIKRESINYENVFNDINKIKDILV"
     gene            36138..37616
                     /locus_tag="KRO40_001321"
     CDS             36138..37616
                     /locus_tag="KRO40_001321"
                     /EC_number="2.1.1.151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-factor II C(20)-methyltransferase"
                     /protein_id="HBH2092143.1"
                     /translation="MKKALLVVSFGTSYHETREKTIDICEDKIKNSLKSHDFFRAYTS
                     NMIINKIKKRDGIEIDNPIQALDKIYEQGYDEVIIQTLHIICGEEFNKLKEQVDGYSS
                     KFKKIVLGRPLLTHIEDYQEAVEAIKHQIPHMESNEAVVFMGHGTLHESHSAYPALEY
                     MLRDNGINAYVGTVEGYPEIEHVIRRLKEGNIKTVNLMPFMLVAGDHAINDMAGDEED
                     SWKTILEENGFNVRVHLKGLGENSYIQDKFVRHAVKCAENAKFYGIGAGPGDGSLLTI
                     KAVNTLKKLDILYTPESKKGGDSLALSIVSEYLPESVEIKSRHFPMSFDGNEKSLAWD
                     NVAQEIISDVNDGKNVGFVTLGDPMIYSTYVYIMKRILGEVEVETIPGISSFSNIASN
                     QNFPLVMDKEALVVIPCTMEDDKIEYALQNYNSIVLMKVYKNFKEIIKKLEKYDLIEH
                     AILVSNSSQESENVFTDLKEAHLEDKISYFSTILVNKDNKIK"
     gene            37646..38551
                     /gene="hemC"
                     /locus_tag="KRO40_001322"
     CDS             37646..38551
                     /gene="hemC"
                     /locus_tag="KRO40_001322"
                     /EC_number="2.5.1.61"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylbilane synthase"
                     /protein_id="HBH2092144.1"
                     /translation="MNIVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDL
                     IQNVSLDKIGDKGLFVKEIEQQLLDGKIDIAVHSMKDMPSYLADGLKFAHTPKREDPR
                     DVLILREGYKNLDDLPHGAVIGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDE
                     NMHGIVLAASGIIRANLQDKISSYLPVDVVIPAPAQGALAIEIRSNDSTIEGIVNSLK
                     DENTEIQILAERGFLDGVNGSCHIPIAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDG
                     DISSPRELGLKLAKLVLKEYENYEG"
     gene            38541..40040
                     /gene="cobA"
                     /locus_tag="KRO40_001323"
     CDS             38541..40040
                     /gene="cobA"
                     /locus_tag="KRO40_001323"
                     /EC_number="2.1.1.107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrinogen-III C-methyltransferase"
                     /protein_id="HBH2092145.1"
                     /translation="MKGKVYLVGAGPGDYKLMTLKGLECIRKSDVIVYDRLANSSYLR
                     EAKPDCELIYVGKASSNHILPQEDINRIIAEKAKEGKIVTRLKGGDPYVFGRGGEEAE
                     TLVDEGIEFEVVPGITSAIGGLCYAGIPITHRDHASSFHVITGHLKGDDSGELNWNAL
                     ANNKGTLVFLMGISNLEKISENLMKEGKDKDTPVALISWATRYNQRVVTSTLENVYET
                     AIKEEVKPPTLIVVGSVVGLREKLNFFESKPLFGKSIAVTRSRNQNSVLVEKIMDLGG
                     NPIEIPTIKVEKIQNNINLENEIKNINKYNYLILTSKNAVEIFFEKIYEMNFDLRILS
                     NLKVCAIGSATSNELKKRGIIADIVPKKFVAESLYEELAPILNDDDNILIPRAENARD
                     YLVDKLKAICEVTEVHIYRTVIDEEKKGEILDILNSNDIDYITFTSSSTVNNLVEIIG
                     KENIKILEKIKTLSIGPITTETINSLGIKLYKESATSTIDSLVDLIIKN"
     gene            40057..41022
                     /gene="hemB"
                     /locus_tag="KRO40_001324"
     CDS             40057..41022
                     /gene="hemB"
                     /locus_tag="KRO40_001324"
                     /EC_number="4.2.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="porphobilinogen synthase"
                     /protein_id="HBH2092146.1"
                     /translation="MLRRPRRLRASKAIRNLVRETKVNVEDLIYPLFVVEGENIKEEI
                     KSLPDVYHLSIDMLEDEIKEISELGIEHIMLFGVPDEKDECASQAFNDNGIVQKAIRK
                     VKEINSDINVITDVCMCQYTSHGHCGILTDTGYVDNDKSLEYLAKISVSHAKAGADMV
                     APSDMMDGRIQAIREALDENGLENVGIMAYSVKYASNYYGPFREAAHSAPSFGDRKTY
                     QMDPANSNEAIIETELDILEGADILMVKPALSYLDIIRRVKDNFDLPLAAYNVSGEYS
                     MLKFAVKEGLLNEDVILESITSIKRAGADIIITYFAKDIAKLLKK"
     gene            41175..41753
                     /locus_tag="KRO40_001325"
     CDS             41175..41753
                     /locus_tag="KRO40_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional precorrin-2
                     dehydrogenase/sirohydrochlorin ferrochelatase"
                     /protein_id="HBH2092147.1"
                     /translation="MLYPINLKLDELDVVIIGGGEVAYRKCKNFLEFNKNVTIVSKQI
                     LNKFYDLKGNIKIIKDDYKEIYIKDASVIIAATNNRELNMEIGLYCRAKNKLVNVVDN
                     IEISNFTVPSYIKRGDLLISVSTGGKSPSLSSKIKKEIEERYTEDYEEYLNVLGDIRK
                     KVIKKYEDKSKRKDVLNMLVTLDLEELKKFDI"
BASE COUNT        16531 a         4407 c         7456 g        13397 t
ORIGIN      
        1 aactaatttt atatataatg actacttaga taaaagaatc taaaaaaaat tatgagagga
       61 ggagtagggt ataaaatcag attataagtt ttaagttatt atactaaaaa gctataaaac
      121 agttatcatg tattttatgt taaaggaaat tgtaggtagt ttatcgaatt gtttaatcag
      181 aagaaaaaat ttcacatggg gaggtaactg agatatgtca gaaaaagtaa atgttaaaac
      241 agtcatcagt ttcgcaggtg cgtatgtagc aacagtaatc ggttctggat ttgcaacagg
      301 acaggaaata atgcaattct tctcttttta tggttttgca ggtattattg gtgggataat
      361 ttcaatggta ttattctcat ggatgggtgc ttcagttatg tcaaaaggta aagagcttca
      421 acttaaagaa cctatcaaaa tttatcgtgt ttattgtggt aagtatttag gaatattctt
      481 tgaatggttt ggacctttat tcttatttgg tgttttcgta gtaatgattt caggagcagg
      541 agcaacttta actgaatact atggattaaa tccatttgta ggtagagtag gtatggcagt
      601 agtagcatta ttaactgttt cactaggtct tgataaatta tcaaagatac taggtggaat
      661 agggcctata ataataatct ttacactttt agttggtggt ataagtttag ctaaaaacat
      721 aggtaatata ggagaagctg cacaagttct tagcactgta aagatagcta aaccagttcc
      781 aaatgcctat ctatctggtg taatatatac tacttataac acaattgttg ttatggcatt
      841 cttaactgga ttaggagcaa gtgctgctaa caaaaaagaa gctatttgtg gtggtatatt
      901 aggtggagta gcacttatgg ctgcagctat aatgatgcac ttagctattc tttctgatat
      961 aggaaactta tattcaaaag caataccatc attattctta gcagataaga tttcaccagt
     1021 aattggagtt ttattctcaa taattcttat attaggtata tatacaacag ctgtaccttt
     1081 attatggtca gtaactaata gatttgtaga tgataaacat cctaagttta aattaataac
     1141 tttaatagca gctatattag gtcttatagg tggcttccta ccatttgata agctggttgg
     1201 tattttatat ccatatactg gatatatggg cgtcataata ctggtttgtg ttctttatag
     1261 acagattaca aaaacatctg gatatcaaga aggaatcagt gacaaataag tattttttaa
     1321 tattgtaaac tcaagagcta tatgaaaaca atgaaaatgt tttcatatag ctctttttat
     1381 tttttagctc gtttattatg aaatagaaaa aacatgtttt ttagttacat tacatatatt
     1441 tataattatg tataaatata tactaatcaa taatttagag tctaagataa gtttataaat
     1501 catatattta gaatatatgg gaggagtgat aagattgaat gtaaagttta atattaaagg
     1561 tataatttat ggagttatag ctcttgtatt cgttataggg ggatttatat tcataccaag
     1621 tatgtttgta gagaaatcta aacccataga ttatacagta ttacaaagaa attcaatacc
     1681 agaaaagata ttagatgtga tggataagta tacaaatgaa gaaagagcat tagcggctaa
     1741 aatcgataac aaaatataca ttatagtgac tagaggaaat aataaatatg gtatagaaat
     1801 ggacaaaata gaaagtgtgg ttgaggaagg aaaggatgtt ttgagagtca agataaagta
     1861 taaagataag gaagattctt ttccatacat agttgttgaa acaaatatga gtgaacttcc
     1921 agatagaata gaattaaatg cgacgaaata agaaggtatt ttataattaa ataactgcat
     1981 attgtacaat aaagtcatgg tttttattaa tgtaagtaaa ttgtgtatgg ttcttattgt
     2041 tgtaaaagcc atgacttaaa atgcttataa agtaagatat taacagtagt atttattact
     2101 acattaaatg gggtctggaa atacttaata ttctaactat ttggagtgat aattctagtt
     2161 tcagtaacta tgtagtctaa ttgtgcatca tgagtttctt ttggaataga atcgaatatc
     2221 tggaagtcaa atgctatgcc gatagttata gcatcttttc ttaagttttc taaaaatcta
     2281 tcataaaatc ctccaccata tcctaatcta tagcaatgta tatcatatgc tacagctggt
     2341 acaattacaa catctaaagc cttaatatca attgtaggtg atttttcgtt aggttctctt
     2401 attccatatg ctccaattct caatccctct tttaaatctg ttatttgagt agggattaat
     2461 gtatgatttt cttttattgt gatgggactt gatactattt tctttagaga caaaagtttt
     2521 ttgattaaat tatctgtttg aacttcattg ttaaaattta gataaagcat tatattagtt
     2581 gcatttctta tatcttccat ttgaagtaat ttttcagtta ttaaatttga attactaagt
     2641 acaaagtttg cactcttatt ttttcttgat tcaataactt tttttctaaa ttcttttttc
     2701 ataaaataat tcctccctta atatgttata atgtgtacag caattgtatt taatataaat
     2761 tttagtataa tttattgtaa taaagcaata tatttgggta aatgtaataa aaataacagc
     2821 tagtcatata ataataatag tttatgtaaa aggagatgta tcttgtgatt tcaaagaaga
     2881 aagctatttt tttaggggtg attttagtaa ttataacagc tatggttaca tcagcatttc
     2941 agttgacatt ggggaataaa gttgtaatat cgaaagaact ctatgaagac tataaaaaat
     3001 atgataagtt gttaggacta gaatctatta taaaacaaga tttttataaa aaagtatcag
     3061 atactgattt ggtaaatgga gcagcaaaag gtctatttct aggaacaaat gataagtatt
     3121 ctggttatta tactaaagat gaaatggaga atctaattaa tgatagtgaa ggttcttatg
     3181 ttggtgtagg tatgtatata ggggcatcaa aagatggtgg cttagtagta gttcccatga
     3241 aagattctcc agcagagaaa gcaggtgtaa aatcagggga taaattagta aaagtcaatg
     3301 gaaaatctgt ctcatataaa aattcagatg aagctgttcg tatgatgaag ggtaaaaaag
     3361 gtaaaacagt tgaactgact atattaagag aagataaaca attgaacttt aaagtaaaaa
     3421 cagaccagat aattgagaag agtatagaaa gtaaagtaat tgataatgat ttaggatata
     3481 tagaaattac ccaatttata tcaagtacat atactgactt tgataaagct ttaaaagaat
     3541 taaaagcaaa aaatatcaag ggattagtaa tagaccttag aaataatcct ggtggaatgc
     3601 tagatatatg taaagaagtt gctgatgagt taattggtga aggaaccata gtatatacaa
     3661 aagataataa gggaaatact gagtacttga aatctgataa agaaaaattg ggacttccaa
     3721 tagtagtgtt aactaatgga gaaagtgctt ctgctgctga aatattaaca gctgcaatcg
     3781 ttgataataa agaaggtatt tctgtaggga ctacaacttt tggtaaaggg ttggtacaat
     3841 cagttgtaag attgaaggat ggaacaggat acaagttaac tactgctcaa tattttacac
     3901 ctaatggaga ttatatcaat gaaaaaggta taaagcctac tattgaagaa aaagatgaaa
     3961 ataaacagtt agatgtagca actaagtggc ttagagaaca gattgataaa taggatttaa
     4021 tttttataaa cttatactat aaaataaaga acattataaa agagatgtct caaaatgaac
     4081 tttttagttc atgaggcact ctttttgtat gaaatcaaat gtattttcat cattttaaca
     4141 atgaaaaaga ggcttatctc tatttttagg aagcctctat aactttatat tgaatctatt
     4201 tattaacttt gtacatacag ataccattta tataagtttc gtgtatatta aagtcattat
     4261 ctgttactat aaagtctgca tccatacctt gatatataga gccacagaca ttatcaatat
     4321 tacaacttaa agcagggata tatgtagcca tttttattgc atcttctaaa gttgatatgt
     4381 tccaatcaac tatatttctc acagccttgt ccatagttaa tacacttcca gctaaactcc
     4441 cactatttaa tcttgcaaca ctatttttta catttacatt aaacttacca agagtatatt
     4501 ttccatcctc catagcacca gctctcatac aatctgtaat taaagctatg ttattactag
     4561 acttagcatc catcattatt ttaacagcta ttgggcttac atgatgacca tcacaaatta
     4621 attcagcata agtatctttt agtaccatag cagccccaac cattccaggt tctctatgat
     4681 ttaaaggact catcccatta tatgtatgta caaacacttt agcacctgaa ttaacgactt
     4741 gtttaacttg ctcaaatgta gctgaactat gaccaagaga aactgatata ttatttttag
     4801 ttgcatatct tgttaattct attgaacctt tacgttctgg agcaattgct attttcctta
     4861 ttaaattttt cgattttttt tgccataatt ttaatatatt gatgtcaggg tctttaaaat
     4921 atttttcatt ttgagcgccc ttatattttt ctgtaaaaaa tggaccttct aaataaatcc
     4981 cttgtatttt tgcaccctca actcgattga agctattgct tatattttct acagaatcac
     5041 ttagtgtatc tacagaatca gttaaagttg taggtaggaa agatgttact ccatatttta
     5101 ataagccttt tgaaattgtg tttattgctt caaatgtatt gtccatgaca tctgcaccta
     5161 aaagaccgtg aatgtgagta tcaactaagc caggagcaat atatttacct gaaaaatcta
     5221 taacattatc agtattatta ggtctttctt gttgaaattc accgaatttg ccattaatta
     5281 tactaaggta acctttttct ttgattccat gtttcataaa aaatttatct gcataaataa
     5341 aacttttcaa aataacctcc ttataattat actatcattg tggcattgac gcttataata
     5401 tcattctgtt ttcttgaaag ctatttaact tactatctta catgtcttac tctatataca
     5461 aatttatcgc ttctagcgac actcaaagta aattcaataa ctatattgtc atcattatat
     5521 gtggtacgaa gtaatttcag acaaggtgaa tctcctggta cttccaataa cttagcttcc
     5581 ttatcagaga ttattccagc tgaaaattct tcatcagcaa ctttaataat ctcgccataa
     5641 tcttctctaa atatttcata taaaggtttt tgttcgattt tttcttttgt caatcctata
     5701 aattctttca taggaagata tgttctttca agcatcatag gaaggtcatc agcaagtctt
     5761 aaacgcatta tttttatcat tttttcacca gtagttatac ctaatttttc agagaaatac
     5821 tttgtacttt ctactacctc aaatgataat acctttgtac ctggcttttt tccttgtgtt
     5881 ctcatataat ctgtaaaact ataactttcc attaagtttt gagaattttg acttagtgca
     5941 gcaacaaaag ttccttttcc atgtcttttg tatatatatc ccatatgttc caactcagcc
     6001 atagctagtc taactgtggt tctacttact ccatattcat cacaaatttt tctttcggaa
     6061 agcattctat cgtttggttc catctcattt tcaatcttag ttcttaatat ctcaacaagc
     6121 tggtcatata ttggtctttt atcatttctt tttatcataa aaatatagtc ctttctaagt
     6181 ggttattacc acaatttgat tatagaatat agaattattt atgtcaatga ataaagttta
     6241 atcaaaattc aataagtaag gctattaatt tattataaaa ttatggtaca ttgacaaaac
     6301 aagtaaaata atttatattc aaattggtaa taaccacttt ggatatatta tatgaggtat
     6361 tttttatttt acagattaat ttattgttta gaaaagtaaa aattaataat gaggagaatc
     6421 tagtatgatt acagtaataa cattcaaccc atctatagat agaatgtata gagtgaataa
     6481 tataaacata ggtgaggtgc aaagggtagt aagtaagaat gcaactgctg gaggtaaagg
     6541 attaaacgta gctaaggtat gtaaaatttt aaaagaaaat cctttagcta tgggatttct
     6601 aggcggattt aatggagaat ttataaaaaa tgaacttaga aaactagata tacaaaataa
     6661 atttacaaaa atagagcagg aaactagaaa ttgcttaaac ataattgagg acaataaagt
     6721 tagtacagaa tttttagaaa aaggaccaat agtagaaaaa agcgatttag agagatttga
     6781 aaatgatata gaggaagtac taaaaaatac taaaatactg gtagcttctg gtagttattg
     6841 tgagaatatg ccgatagact attatgaaaa gataggaaat acatgtagag caaataatat
     6901 aaagtttata ttagatacat caggagaagc attaaaaata gctttaaaat caaaaccata
     6961 tttaataaaa ccaaatatag atgaaataag acatttatta ggaatgaata tagaatcaag
     7021 agaggaaatt atcttgtcag gaaaaaaact tattgaaatg ggtgcagaga atgtatgtat
     7081 atctttagga aaagatggta tggtgtattt aaacgaagat aatgtatatg atgtaaaagt
     7141 accagttgta aagtgtataa atactgtagg tagtggagat agcacagtgg ctggatttag
     7201 tgtaggtatt ttaaggggtt ataaaataga aaatttactt aaatttgcaa atgcttgtgg
     7261 tataagtaat gctttaaata tggaaactgg atttgtagat ttgggagaaa ttgataaata
     7321 tcaagattta gttgaagtaa aaaagttaag ttaaatacat ttaatgggaa tataataaat
     7381 ttaatgttgt tgtaatagat tttaatttta atataaaaga tatagtctta tataaaaata
     7441 ggttagaaaa attcattttt aacctatttt tataataaat atctatttta ctgaatttat
     7501 aattttctct agtaatcttt gagctttgat acactcttct ccattaatag ctggttttat
     7561 attattttct atacaatcaa taaaatgatt tgatatatcc tcaaaaccct tttgttttaa
     7621 tatatttacc catgcaccac tttgctttaa agttaggttt ccaccttctt ctatttccag
     7681 tacattaaga ttcttaactc tttgaatctt accctttgaa agaatttcaa cttgttctaa
     7741 ctttgttcca gaatctctat gcatagaggt gtttatagag aaatttttac ctttaagttt
     7801 atgacttaca aatataagat tcttattgtc tgttaaaaat aaatcctctc cactaatttc
     7861 aacatcttca tttgctaacc ataaagcagt gtcaataaca tgtatatagt catctataag
     7921 agtactgtcg aatctaacat ttcttaagga atttaatcca tgtttacata tattgataga
     7981 tacaatttct gtagcattat ttttaatttc tttgtacata ggacagaatc tacggttgaa
     8041 tccaaccatt aaatttaagt tttttttcgt acttaactcg ataagttctt ctccttgact
     8101 tactgttgaa gcaagaggtt tgtctacata tacatgaaca cctaaattta ataatatttt
     8161 tataatttcg tagtgtgttt ctgtagagct atgtagaaaa atacaatcac attttttagc
     8221 tagggattca atagaatcga atggcatgat tctataatca ctacagactt tttccctttt
     8281 aactttattt ggagtaaaag ctcctacaaa ctcaaatctc tcagacttag ttaatatagg
     8341 taaatatgcc ttttgagcta tggagccaag acctatcatt cccattttta tatttttcat
     8401 aatactttct cctaaggttt ttatatttac agaattgatt ataattcaga cacataaatt
     8461 tgtaaacttt gtatcaaaaa ataaatttaa agcttatata agtaaattag cgaaataaga
     8521 aatattgata aagtaatttt gtaggatatc cataaaattg attgatataa atattttatg
     8581 tattgacaaa aaattcaaat taatttatat ttggattagt ggtaattacc actttggtct
     8641 gaacaagctt ttatcgtaaa ataaaaatac taaagtatat agagtatgat tttattaaat
     8701 ttttaaagat aaactataaa attaattaaa atctatagtg tatattttat agtgagttta
     8761 agtagtacta aaaaatctaa gcaaaaaatt ataaaagagt atattttttt atagtttaaa
     8821 gtggttataa cctcattacc aaatgtaaac gttacaagta tgaaaggaga atgaaaatgt
     8881 ttaaattaga agaacaaaaa ctaaaagatt taggtgcaat aataacaact aatgaaataa
     8941 aacaacagcc tgaattatgg ttagaaactt atgaaatata taaatctaac aaagaaaaat
     9001 taagtagatt catagataca ataagtaata atcatgggca gtttagagtt atatttacag
     9061 gtgctggaac ttcagcttac ataggaaatt caatacttcc ttaccttaaa aataaaaatg
     9121 acataagaaa atacatattt gaagcaatac ctactacgga tatagtttca aacccatatg
     9181 attacttaaa aaaagatata ccaacattat taatttcatt tgcaagaagt ggaaatagtc
     9241 ctgaaagttt agcagcttta aatttaggga ataagattgt agataatttt tatcatttag
     9301 ctataacttg taatccagaa ggagaactgg ctaagatgac taaaaacgac gaaaataatt
     9361 acttgttatt aatgccatca aaatcaaatg atgaaggctt tgccatgaca ggaagttttt
     9421 cgtgtatgat gttatctgct atgttaatat tcgatagttt agaagatgat gtagaaaagt
     9481 catatataaa tgcaataatt gaaatgggaa gaaatgttat agatagaaaa gatgaaatac
     9541 atgagttaat aaataaagat tttgatagag ttgtatattt aggttcagga ggattaggtg
     9601 gtttgacaca agaagcacaa ctaaaacttt tagaacttac agcaggaaaa atatctacag
     9661 tgtatgattc tcctatgggg tttagacacg gaccaaaatc atttattgat gaaaatacac
     9721 ttgtatttga atttgtatct aactgtttat atacaagaaa atatgattta gatgttttag
     9781 aggagataaa aagggataaa attgctaaat tcacttgtgc agtgtcagta gaaaatgaaa
     9841 ataacttctc aggaacaaag tttgagttta aagaaaagta taataaatta ccagatgtgt
     9901 atcttgcaat gccatacata ttgtttgcac aaactatagc attgtttgta tcagtaaagg
     9961 ttggaaataa gccagatact ccatcagcta caggaacagt aaatcgagta gtaaaaggtg
    10021 taacaatata tgaatattaa aagataagat taaaatatta taactaaata atttgggagg
    10081 gtatcaatgt ggcattagta acaacaacat caatgcttaa aaaggcacaa gatgaagggt
    10141 atgcagtagg agcatttaat gtagaaaata tggaaatggt aattgctgtt atagaagctg
    10201 ctgaggagtt aaattctcca gtaatattac aaactactcc atctactgta aaatatgcag
    10261 gtcttgatta ttatctagca aatgcaaagg ttgctgcaga aagagtaaat atacctgtag
    10321 caatgcatct ggaccatggt tcaagttttg accttgcaat gaaagcttta agaagtggat
    10381 atacatcaat aatgatagat ggttctcatg aaagctttga aaataatata tctatatcta
    10441 aatcagtagt aaaagcatgt agtccttctc ttataccagt ggaagcagaa cttgggaaag
    10501 ttggtggaaa agaagatgat ttagatggcg ggaatagtaa tgattataca aatccaaaag
    10561 aggcaaaaga gtttgtcgat agaacaggaa tatcttcatt ggctattgct ataggtactg
    10621 cacatggatt gtataagggt gaacctaaaa tagatttaga taggttatca gaaattaaaa
    10681 atgtagtttc aataccttta gtattgcatg gaggttcagg aatacatgat gatattataa
    10741 aagaagctat aaaaagaggt attgcaaaag ttaactatgc aactgaatta agaattgcat
    10801 atagtaaagg ggttaaaaaa gttttagatg aagattctga ggttatagac cctaaaaagt
    10861 atggattagc agggcttcaa tcagtaaagg attttgtgaa agaaaagatt aaagtgtgtg
    10921 ggtctgtaaa tagagtataa aaataaaata tcctaaattt attttagata agtttaggat
    10981 atttattata tgaaaaattt atattaatta tatgtaaatg gtgtattttt ttcatttaat
    11041 tgatgaaaaa tatcagcttt tattggtaaa gtattacata tataattaaa atatactaaa
    11101 aattgaacta tatattttat tattataaaa tatttatatt aaattgtgga attaaaatat
    11161 actaggatat aaaattctta aataaaaaga aaaggttgtt tttataaaaa atatttttta
    11221 taccacttta aaaaacacaa taataacact gagggaggtg gggatatgag agaacgcatt
    11281 attcttgaaa cattaaaaaa tagtagtggt tatctaaaca tagattattt tgcagataag
    11341 ttgggggtat ctactcgaac tatcagaaat gaaataaaaa agatagaaac tataaaagaa
    11401 tgtaatggtt ttaaattaga atataagtct aaattaggat atattctaaa tattaaagac
    11461 caagataaat tcgagcatta tctaagaaac ttaccctcag atttagttga aaatccagaa
    11521 caacggttgg agtctataat agtagagctt ttagtaaatg aaggttataa aactatagaa
    11581 cagttaagta aaaaatttct agtaagttca tcccaaataa aaaatgattt aaaaaagata
    11641 gatgaaaaga taaaggatac agaattaaaa ctagagcgaa aggctcatta tggaattaaa
    11701 atagaaggtt ctataaaaga aattcaaagt atattggtgg atagttattt tagagggaat
    11761 agaaatataa cagagtacag gaataagttt atagataatt taaaattagc taatattaga
    11821 agtacaataa aaaatgtact taatgaacat gatttagaag caaatttaac agaacttgag
    11881 gaaatattag cacaaattat tatattgtat ataagagtta gtatgagagt agtgggaaat
    11941 gctagcgatt taaaattata tacagaagat ttaattatag ataaattatt agataaaatt
    12001 tttagagata aaaaatataa ccttaattat gatgaaaagt attatttaaa ggagcttata
    12061 aaactaaaga ctaaagataa gaaagccact ataaagaata ttgataagaa taaacttcaa
    12121 gatattatgt tcgaattttt tagagagata gataaaaaat ataactctaa ttttttagaa
    12181 gataaagagt tttttaactt attttactta catattgcat gtttaataga acgtataaag
    12241 aagaaccaca agataataaa tcctttttca gttaaaataa gtcaacagta tccaactgtt
    12301 tttaatttat ctattcaatt ttcaaaaatc atagaaaatg agtatcatat aaaaataagt
    12361 caagatgaaa tagggtttat agctactcac attgctgttc cttttgaaaa gagagaagaa
    12421 gctaatttta ataaaaaata taaaatagca ataatatgct cttctggtgg aggtagtgca
    12481 tttttgataa atttaagact taaagaaatt tttccaaatg ctgagataag aaatttttca
    12541 ttactagaag aaaaagctgt aatagaattt gcaccagatt tgattttttc aataacaaat
    12601 cttttatttg aaataaatgc tccagttata cttataaatg aaattttaga cgaattggat
    12661 tatttagata ttaaagaaag tgttagattt gcagaccata taggaaatat atcaagccca
    12721 aaacaatata tattaggtct atttgataag aatcacttta ggtgtataaa agataaagct
    12781 aagtataagg atatccttga tagtatgtca aaatgtatag ttgacgaggg agcttgttct
    12841 ccaacctatc ccaaagatgt atgggaaaga gaaagttatt tgagtactat ttatacaaat
    12901 ggggtggcta tacctcatcc aatcgagatg acaggaaaca aaaatataat atcagtagct
    12961 ttgatacaaa ctgatattat ttatgaaaat agggtgccta aaattatttt catgatttca
    13021 ttaataaagg gaaatttaga acttcataag caaatatcta aatatttaag taagattatg
    13081 gcaaataagg atatggtaga catgctaaat aagtcacaat cttatgaaga gtttatgtat
    13141 aagttaaaaa tctatctggg aggttagaca tgaatataga gttttttaag aggttgtcag
    13201 aagcagatgg tatagcatct aatgaagaag aggttagaca tgttttattg gaagaactaa
    13261 aagcttatag tgataaaatt atctgtgatg ggctagggag tatcatcttt tctaaaataa
    13321 aagatgagag tgcaccaaac gtaatgattt gtgctcatat ggatgaagtt ggatttatgg
    13381 tgagaagtat agacaaactt ggtatgattc acttaataac aataggagga gtaaaacctc
    13441 ttgcacagtt tgtacaaaaa gttagaatta caacaaaaga agggaagaaa atccccgctg
    13501 tcataaatgc tacatataat aatggtaagg ctgaaaatat atatgcagat attggagcat
    13561 atacagaaga agatgtatat aacctaggga ttaatgttgg ggatatggta acatatacaa
    13621 caagctttga ggaatttact ttaccagacc gattagtggg aaaggctttt gatgatagga
    13681 taggatgttt tgtgatggga gaagttttaa aagaacttag gaaagaaaat ctaaattgta
    13741 atattcactt tgcggctaca agtagtgaag aggttggaat aaggggagca aagacatcaa
    13801 cacagttaat aaatccagat atagtatttg taatagatgt agcatgtgct aaaaatgagt
    13861 ttgtgagaga ctatacaaat aagaaacaaa ttgataaagg tgtaatgcta atgcatagag
    13921 ataggactct agtccctagt agaaaaatga tagattatgt aatggaaatt gctgataaaa
    13981 ataatatacc acttcaacat gatatgtttg aatcaggtgg gactgatgga ggagaagcac
    14041 atctcgtaaa tgaagggaaa ccttgtgtag taacttgtgt accagttaga tatggtcatt
    14101 gtgcattttc aatagtaagt aataaagatt tggagaacat tataagattg tatacacagt
    14161 taattttaaa ttttgatgaa gaacaatata aacatataag aaattttatc taaaggagaa
    14221 taagaaaatg tcaacagaag tacaaataat ggaacttata tcaactgcag gagagagtaa
    14281 atcgaaagct tttgaggctt taaaaaaagt gaagtcaaaa gattttaaag gagcaaaatt
    14341 gttaatagag gaggctcgta aaatagatat tgaagctcac aggatacaaa cagaattaat
    14401 aactcaagat ttaaatgaag atgttgaaag tccagcaatg agtcttttaa tggtacatgc
    14461 tcaagaccac tatatgactt ctcagctagc aaaagacttg atagaggctt tgatatattg
    14521 tcttgataag taattgtaat atagaaatag attatttatg taaaaattct tttaaaagtt
    14581 tagatgcttt taagagataa taaaaataca aactttagga ggaattatta tgaaaatatt
    14641 attatgttgt gcaggtggat tttctactaa tatgttaatg caaaatatga aaaaggtggt
    14701 aaaagagagt gctaaactca atgaaaaaga ttttgagttt acagctatac cagcagattc
    14761 aatagaaagt gaagttgatg attgggatat agtacttata ggtcctcaaa tagctcacaa
    14821 aatagacttc ttaaaaggaa tattagagcc aaaaaataag ccttttgcag taatagataa
    14881 agatgtatat ggaaaaatgg atggagctac agttatgaag ttggcattaa taacttataa
    14941 gaaacatcaa ttagctcaag gataataaaa ataatgaggg aaaagggaga ttagatatgt
    15001 tttcaaaatt tgaagcattt atgaatagag tatttatgcc tttagctcat aaggttgaca
    15061 atcaacgtca ccttggttct ataaaggctg gtatggttgc tatgacacca ttcacaatat
    15121 taggaagtat atttgcaata cttccagcac ttccaaatat gcttggagaa aataatccaa
    15181 taagcaaatt catacttagc aattcagcaa tattggattt accagtaagt ctttccatag
    15241 gtttaatagg attatatgct tgtatgtgta ttgcttttaa tctggggaac tactataaat
    15301 tatatatacc aggttgtgtt gcactatcaa ctttttcttt tttattccta gtagcctcat
    15361 ttacaccaga tggagcttta gaaataggaa atttaggagc taaagggcta tttacaggta
    15421 tgatagcagg gcttggttct gtggagttat ataatttttg taataagaag aatatcacaa
    15481 taaaaatgcc agaaaatgta cctgattttg tatctaggtc ttttgaatta atacctacta
    15541 ctataatagt ttgtggaact tttatagttg ctcgttttat ttcattaaaa gtatttggag
    15601 aattacctcc acagatactt actcaatttt tatctccatt agtaggaagt atggataacc
    15661 catggtcagt tcttgcactt aactttgcta tatgtactat attctttttt ggaatacatt
    15721 catcagtatt tagtcctata actagaccta taatgattac atttatagct gaaaacatag
    15781 cagctatgca ggctggagaa acaatacctc atttctttac agcaggagct tcaagtgcat
    15841 tctttggatt tacaggatgt ggaattagta taggttgtgt aattgcatgt atgttatcaa
    15901 aaaatgcttc ctataagaag attggacgtg tatcattatt ccctgcatta tttgggataa
    15961 atgaaccaat attatttgga gcaccgataa tattaaatcc aataatgttt ataccacatg
    16021 tatttggtgg agctataata ggtacactac caatgttttt tatgcactgg ggatggttag
    16081 caaagccagt atttgaccct ccatatgtag gggtattctt agaaggattt ttaactaatg
    16141 gagattggca ttctatatta gcaaatgcat tgcaattagt attagcagtt ttattatatt
    16201 ggccattctt taaaataatg gaacgtcaac aaaataataa aaaacaaaaa gaagaaacta
    16261 agaatatatt ctctaaagaa gaagaagact tattggatga tttaggattg gatttctaat
    16321 attttgttat gaataataca atggagagat tagtatcctt aatctataaa agaggtgttg
    16381 acgctctttt gattaaagca aaaaatacta aaagatatat aggagcttta tcaggtagtg
    16441 gtgtatatgt gcttgttact aaggataaaa attatcaaat tctagatggc agatatattg
    16501 atgaagcaga taaaaaaacg actggtttca taaaaaggat tgtatctcaa ggttcttata
    16561 taccaactat aattgagtta ttaaaagaat taaatataaa aaagttagca atagaaaacc
    16621 aagctatgag tatacaagag tatctttcac taaaaaatga aggttttgaa atcaatttaa
    16681 taacaaatga attatggaag ctaagggcta taaaatctaa agaagaaatt aaacttatta
    16741 aaaaggcttg tgagattaca gatgaagtat ttgatgaggt tatttctgaa attaaaaaag
    16801 atatgactga gctagaagta tcagctctaa ttcagtatca tgcattaaaa aaaggtgcaa
    16861 gtggaatgtc ttttgaaaca atagtggtat caggagaaag aggtgcaatg ccacatggaa
    16921 gacctacaaa caaaaaattg aaagtgaatg aagctataac aatagatttt ggtgttgttt
    16981 atcaagggta tcaatcagac atgactcgta caatatctat aggcaaacct cctaaaatta
    17041 ttaaagagat atatgatgta gtattggaag cacaattatc tgcaatagag tcaataaagg
    17101 aaggaactag ggcaagtgat gttgacaaag tggctagaaa aattatagat aaacatggat
    17161 ttggcgaata ttttaatcat ggactgggtc atggtatagg tcttggagat ggtgaagttc
    17221 ccactttaaa tccaaatagt gaagatatat tagtggaagg aatggtaatg tcttgtgagc
    17281 caggtattta tattccaaat gtagggggag ttagaataga agatgatatt gttataatag
    17341 atggaaaagg tgttccactc aataagacat ccaaagagtt tataatatta ggagagtaaa
    17401 attatgaaat ataattttaa taaagtatta aatcgtaaag aaggaaattg tagaaaatgg
    17461 agcaaccatg tgattaaaga aaaatttggc ttaaatgaag atgcaattcc tatggattta
    17521 gctgatatcg attttgagtg tgctcctgct ataaaagaat ctatcttaaa aagagcatca
    17581 gtaggagatt atagttatac ttttatagga gatgacttct atgatgctat tataaattgg
    17641 aataaaagaa gatttgatgt atatatagaa aaggattgga taaaattaac ttttggtact
    17701 gtttcaaccc ttcattatat agtccaagca tatactaaag aaggagaggg tgtattgata
    17761 aatacacctg cttatgaccc ttttgcagag gctgtagtaa ataataatag aaagttgtgt
    17821 tgtagctcat taaaattaga taacaataga tattatttag atttagagga tatggaaaat
    17881 caaatgaaat acgagaatat aagattgctt atattctgta gtccacaaaa tccatcaggt
    17941 cgtatatgga caaaagaaga actatatcaa gtgtcagagt tatgtttaaa gtataatgta
    18001 attttggtaa gtgatgaaat tcatagagat ataatattta aagattatag atttgtatct
    18061 ttgtggaatg ctcatccaga aatttataaa aatagtataa tctgtgtatc tcctaataaa
    18121 ggcttcaact taggtggatt aaaaacatca tatgtattaa taagagatgt aaaaattagg
    18181 gagactttat tagaaaggct aaaaagtaat tcaataactt ctccaaatgt atttgcaata
    18241 ccagcaatag ttgcagcata taatgaaagc gaagaatggc tagatgctat gactagttat
    18301 gtagaggaga attttgaaat agtttatgat ttctttgaaa ctaatatacc aaaagctaaa
    18361 gtgatgaagt cagactcttc ttttttagcc tggatagatg taagagaagt atttagaaat
    18421 gaagaagaat ctaaagaatt ttttagacat gcaaacttaa ctatggtagt tggaagttat
    18481 tttgtgaaag atggagatgg atttattcgt attaatgtgg ggtgtcctag agaaacatta
    18541 aatgaggctc taaatagaat caaaaaaacg tatataagta tgtattgtta aatcataaaa
    18601 aaagtatcta tggtttatat aaaaacacat tatttagtta tcaaatatta ctggaatttt
    18661 gtattccagt aatatttttt gattaaggaa tattattgag gaatattaaa taatattatt
    18721 tcataccctt atattaactt atataaaaat attttattat tttgggaacg ggttagctaa
    18781 cctttatcta gtgtatattt atattgtaag aagcagtaaa aacttttcct ttactaagtt
    18841 tattaataaa cttcttatct ttataaattt tgttagaatt tatactatca gcaagaccat
    18901 accaaggttc tatacataaa aaaggagcag tagaattagt ttcactataa taaggagtcc
    18961 aaataccaac tagagggaaa tcttccatag atatagttac atatttacta ccatcattat
    19021 tacatataga cacttcatct atgttggtgt atatcaaagc atcattcttg aatacttctg
    19081 gatttaactg taagtttttt aattttccaa taggtattat atcatctgta aaagaaccat
    19141 ttaaattgat tttttctaca tcatttttac ttttaaactc aaggtagtgt ttagaaaaat
    19201 cattttgttc gtaaaaagga aggttgaatg caggatgtcc acctatagaa aagaatatat
    19261 ctttagaatc agtatttttt acaatccatt ctacctcaat actattatca tttaatgtat
    19321 agtttatgat tagctcaaaa gaatatggat acttctttaa agtagattca ttatctgtta
    19381 atttataagt tacaaatgta tctcctttat ctacaatctc aaagtccata tctctagcaa
    19441 acccatgttg agtcatgcta tataaatttt cttctattat tgtttcatta tcaaaaagtt
    19501 tacctactat agggaacaat ataggtgatt gtctacccca atatttttta ttaccatccc
    19561 aaagaatgtt tttgtcgtat tttttagaaa atattttagt tagttcagca ccaaaactgc
    19621 ttgattcgat aattaaattt tcattttgta atatattcat ttaaaatctc ctttattata
    19681 ttttatgagt atattatact ataaagtata aagattatta aattttattt gatattatat
    19741 ttgaaaggta gattttagta tattttgaaa attttgtttt gaaaatttgg gattatttaa
    19801 gaaattttgt attataaata gaaggaaata gataaattgt atagaataaa atatattaag
    19861 ataagttaat aatgttaaat gggaagtgag tttatggaaa aaccaaatac aaaagttgtt
    19921 aactttcaag agtataaaga cagaaaaaac caaagagaag taaatagaga cgaactttta
    19981 aagcttataa aaaaaattgt gacttcaaaa tagggagttg ttaaactccc tattttaatg
    20041 ggtttcataa taattaagac attctaagtc catctatata atctttgaat tgtgagaaat
    20101 ctgattcact acttaattct atggtttctg aaccttccgt ataaaaattc ttaagataga
    20161 tagtataatt attatcaaca caatcatgat aaatacatct atatccatct tcatacaaac
    20221 tttttaactt agaaaaatca tccacaatat catctcctta aagttctttt aaatatattt
    20281 ttacaaaaag catctaattg tatgcaaatt gacaatgtaa aataaaggaa atgaacataa
    20341 aatgtagaat aatttttata tgtatgtaaa aataaaaaga aaaagttgaa atttttagaa
    20401 aataagagta ttttttatct aaaaagagag tttaaaaaat aaaaaaatgt tgggaggata
    20461 aaaaatgagt ttattagaaa gtatatcaaa aaacatatat tccctagata actcttctat
    20521 tgaaaaaaca aagcagagat tggataggct tatacatcca actggaagct taggaaagat
    20581 agaagatatt tgcatgcaat tagcaggaat atttggcaat gaaaattttg acacaagtaa
    20641 aaaggttata attgcttttg cgggagacca tggtgtatat gaagaaggcg tagcacctga
    20701 ccctcaaaat ataacaaaat tacagtttcc aaatttttcg aaaggtctat gcggagttgg
    20761 agtaataagt aaatttgtag gggcagatgt tgtagctgta gatgtaggaa taaactgtga
    20821 tgaaaaactg gatggggtat tagactacaa gataagaaaa gggacatcaa atatggcaaa
    20881 aggtccagct atgagtaaac aagaagcaat tagatgttta gagataggta ttgaaatagc
    20941 agagcagtgt atagaaaaag attataaggt tattggtatt ggggagatgg gtatagcaaa
    21001 tactactcca agtacagcaa taatatctgt aatttcaggg tgtgacccgt tagaagttac
    21061 tggtataggt gcaggtctta agaaagaaag actaaagcat aaggctgaag taattagaaa
    21121 ggctattgaa attaataatc caaatccaac tgatggagta gatattttat ctaaagtagg
    21181 agggtttgaa ataggctcaa tggcaggtgt tatattaggt tgtagtgcta ataggattcc
    21241 agtagtaatt gatgggttta tttcttatgc agcagcatta attgcatata agataaatcc
    21301 aaaaactaga gaatatatga tagcatctca tttatcagca gaatcaggaa ctaaaagagc
    21361 attagacata ttaaaattag accctctatt aaatatggat atgagattag gtgagggaag
    21421 tggagctgct ttagcatttg atataataga agcttcaaac tatacttata aaaatatggc
    21481 aacttttgat gaaattgaca tgggaagata aatataaaaa tttaatatgt aggagtgttt
    21541 tgatgagtaa aattattcta gtaacaggag gagctaggtc agggaagagt aactttgcag
    21601 aaaaactatg ttttgacaga aataataata cagcttatat agcaacctct attccatttg
    21661 atgatgaaat gaaagataga gtaaaaaaac atcaagagaa tagacctaga aactggaata
    21721 cttatgaaat atatgaagat atatattcca taattaagga gatatataaa gaacatgaaa
    21781 ctgttatact agattgtgta acattattag taaataatct aatgtttgaa cacaatctaa
    21841 atatagaaga atctagtcaa gaagaaataa acaaattaga acaatacata aaagaacaag
    21901 ttgtcaaact tattgaagaa atagaaaaaa caaatctata ctttgtattt gtaacgaatg
    21961 agttaggtat gggaattgtt cctgggaata aacttagtag aatttatgct gatattgtag
    22021 gtcgtataaa tcaatatata gcttcgaaaa gtaatgaagt ttattttgta gttagtggca
    22081 tagctatgaa gataaaggag tagtatgcaa ttatgaaaag atttatttta atactacagt
    22141 ttttgacaag gatacctata aaattaaatg taggatttga tgatgaattt tataagtcaa
    22201 tagtatattt tccacttgta ggttttgtca taggtatatt atcctattta ataggatgga
    22261 tttctatgct tttatttgaa ccatttatag cttctataat aataactcta gctggtgtct
    22321 taattactgg aggacttcat atagatggat taggagatac atttgatgca atatatagtt
    22381 atagggataa agaaaagatg cttgaaataa tgaaagattc aagattaggt acaaattcac
    22441 ttctagcaat tatgtttgta cttttattaa aggttggatt cgtttacgat ataataagta
    22501 ataattcatt gtgggttata atttttatgc caatgattgc aaggttagga gtaatgttat
    22561 tgacatataa aactgtgaca ccaagagaaa aaggaatggg aaatttattt ataggaaaat
    22621 taactacaag tatgttaata actgctataa tatacacatt attgatagtt gctcttatta
    22681 ctaaatttat atttttatta cctaatatag tgttgattaa agtattaggt tcgattatag
    22741 tggtttttgt atttataata ttattcaaaa aacatattta taaaaaaatt gacggagtaa
    22801 caggagatat attaggctgt ggaatagaac tttcagagct tgtatattta atttacatat
    22861 atttgttaat ttttatgttt ttttaaagta aaaagtggtg ataatatgat aagattaata
    22921 ttaataagac atgcactgac aaatgataat aaaaaaggaa gattatcagg ccatataaat
    22981 agttgtatta gtgaagaggg caaactacaa ataaataaaa ttaccagata tctgagtaat
    23041 gaaaacatag ataaggttta tacaacacca tctacacgta ctaaagatac agtagaaaaa
    23101 atatcaaaat tgaaattatt agaaatagaa gaaaaagaag ctttaagaga aattagtttt
    23161 ggagactttg aaggaagaac ttttgaagaa attaaaatca aatatccaaa tgagtttgaa
    23221 aaaatgataa aagaaggtaa caactataga tatccaaatg gagaaagttt gatagactct
    23281 tataaaagag tggcaaaaga aattgataat ataattttag aaaataatag taatttagat
    23341 acaaagacaa tacttatatg ttctcatgca ggaacaataa gaaatataat aacacatttg
    23401 atttctggta gttataagta tcactggaac tttaaaattg ataatgcatc tattacagtt
    23461 ttagaaattg atggtggatt tgctgtaata gataaaatga attttacaga cttcatataa
    23521 tttaatcaaa accaaacatt acaatctgtg tttgtaatat atctgtaaaa ttagcaatga
    23581 aaatagaata ttagattaaa attaggttct taattagatg ttaaaaggga aaaaggttag
    23641 atgcctttgc agcccccgct actgtgaaac caacgaaact ataaatacca ctgtcagttt
    23701 gatgggaagg ttatagaagt aggatgaagt taagccagga tacctgccta atttaattta
    23761 aaacaagagg tcttcggggt gaaagatttt taattaatat atataaaagt cctatcttta
    23821 gaagtattag gacttttttt aatttgtttt ttagtaaatt ttaacaagga gggatggaaa
    23881 gtggggaaaa aaataatgct acaaggaaca gcttcaaatg taggtaaaag tgtcttagta
    23941 gcaggtttgt gtagaatatt taagcaagat ggttatactg ttgctccttt taagtcacaa
    24001 aatatggctt taaattcttt tataactaaa gaaggattag aaatgggaag agcacaagta
    24061 tttcaagcag aggctgcgaa aatagagcca atagctgata tgaatccagt tttattaaaa
    24121 ccttctggaa ataataaaag tcaagttatt gtaagaggta aagttgtagg agaaatgcct
    24181 tcttctaagt atcatgatta taaattggag ttagtagatg tgttgaagga aacatttaat
    24241 agcttaaatt caaggtatga tattgtagtt atggaagggg caggaagtaa tgcagagata
    24301 aacttaaaag atagagatat ctctaatatg ggtatggcag aaatagctga tgcacctgta
    24361 ataatagtcg gagatattga tagaggaggc gtatttgcct cattagcagg aacaatgctt
    24421 ttattaaatg aagatgagaa aagaagagta aaaggtgtaa taatcaataa attcagagga
    24481 aaaaaagagc ttttacaaga tggtgtaaag atgctagaag acatcataaa agtacctgtt
    24541 ataggagtag taccttatac agatataaaa atagaagatg aagacagtgt aactacgaga
    24601 tttaagaaaa aaatgaataa aagtgatata cacatagaaa taattagaac cccacatatg
    24661 tcaaatttta cagattttaa tatatttgag acacaagaag atgtaagtat aagatatgta
    24721 gactatggag aatctttagg aaatccagat atattaataa tacctggaac taaaagtact
    24781 atagacgatt taacatatat aagaaaaagt ggtcttgaat cgcaaatcaa aaatttacat
    24841 agtcaaggta aattgatatt tgggatatgt ggtggatacc aaatgttagg taaaaaatta
    24901 aaagaccctt atcatgttga aagtgaaatt gaagaagttg atggaatagg tcttttagat
    24961 acagaaacaa cgtttgagaa agaaaagact acaacacaag tagaagctac tattgttgaa
    25021 tgtatcagtg aatacatgaa taaccttaag ggaaaaaaag taaaaggtta tgaaattcat
    25081 atgggaatta caaagcgagg taatgatgta agaagtttag atttaataac taaaaaactt
    25141 gataaagaag tgaattatac tgagggaagt gtaaataaag aggggaatgt aattgggact
    25201 tatcttcatg gaatatttga tgaaataagc tttacaagag caattttaaa caatataaga
    25261 aagaaaaaag gtttaggaga attagaaagc aaagtaaact cttttaatga atttaaggat
    25321 aaagagtatg ataagttggc tgatttttta agagaacatt tagatataga gaaaatatat
    25381 gagattatga aataatgatg acctttattt ataatttagg taggaggtgt attatgaaaa
    25441 aaattttaat tgcgggtact aatagtggag taggtaaaac aacaatatca ttaggaataa
    25501 tgcaagcttt ggttaagaga aatatgaaag tacagccata taaagtaggg ccagactata
    25561 tagacccttc atatcacact tttataactg gaagacattc tagaaattta gattcttata
    25621 tgttagatga tgaaaaaata aagtatatag taaataagtc ctcaaaagat gcagatattt
    25681 cagtaataga aggtgttatg ggcttatatg atggttttgg aatagattta gataattgta
    25741 caagttcaca tacttcaaag gtattaaagt cacctgttat attagttata aatggtaaat
    25801 ctatggcagc atctagtgct gctatggtac ttggatataa ggaactagat aaagatgtaa
    25861 atataaaggg tgttatagta aataatgtaa agactaatag ccattatcaa ataattaaga
    25921 gttctataga aaaatattgt aatgttgaag tattggggta ttttcctcca aataacaaat
    25981 tctctttgga atctcgacat ctaggattag ttcctagtgt agaaatgaaa tcactaaggg
    26041 aaaaatttta taccttagca gatgaaattg aacactatat agatattgac agaataattg
    26101 aaatatcaga aagtgatgaa tttgagagtg attttgattt tcaaactttg atagaaaata
    26161 ataaaataaa agaacatgtt aataataaat caatagctat agcatatgat aaagcattca
    26221 atttttatta tagagaaaat atagagcttt tagaggaact tggtttagaa ataaactatt
    26281 ttagccctct tgaagatgca tcagtgccaa atgcagatta tatatatatt ggaggaggtt
    26341 ttccagaaat atttggaaaa gaattagaag caaatgagtc aatgagaact tccatattag
    26401 aagcacataa caataatata cctatttatg cagaatgtgg aggactgatg tacctaggtg
    26461 agaaactatt gaatcaagaa gaacaagaat ttaatatggt tggaatattt agtggaatta
    26521 gtaagatgac atcttcttta aagagatttg ggtactgtat tggtgtagcc aaggaaaata
    26581 ctcttttatc taaaaaaggg gaatctatta aagggcatga gtttcatcat tcaatatttg
    26641 aaagtgatga aaaatgtgta tattcaatga gaaaagaaag agatggaaat atagtagaag
    26701 agtgggatgg tggttatagt aaaggaaaca ctttggctac atatcttcat actcattttt
    26761 ataataactt aaattgtata gaaaattttt tgaaaaaagg aaatgaataa atgagtattt
    26821 tatctattta tataggatat gtgacagact taattgtagg agacccatat tcttttcctc
    26881 atccagtgag atttattggt aaacttataa attttactca atgtataata agaaaggtct
    26941 ctaaaaatga taggcagtta aaatttgggg gatttatatt atggcttata accgttggaa
    27001 taacatattt aacaacttat gctatagtga agttatttag ttttaatata ttattgagta
    27061 ttgtagtgaa tagttttata atttatacaa cactagccac aaaatgttta aaagacgaag
    27121 cattaaaaat ttataatgta ttaaaaactg aagatataga aaaatctagg attcagctat
    27181 cttatatagt aggtagggat actactaatt taagtgaacc tgaaataata agagcaactg
    27241 tagaaactgt tgcagaaaat actgtagatg gtataattgc gcctatgttt tatgcattta
    27301 ttggaggagc accacttgct atggcctata aagctatcaa tacattggac tcaacagttg
    27361 gatataaaaa taaaaagtat aaagatattg gttttgcatc tgctaagatt gatgatatag
    27421 ccaattatat accagctaga atatctgtca ttcttatgac aattggaagt ttctttttaa
    27481 attataacta taggaactgt tttaaaatct ctattagaga tagaaagaat cataaaagtc
    27541 caaattgtgc tttttcagaa ggtgcagtat ctggtgctct aggaatacaa ctaggaggta
    27601 ccaacgttta ttttggggaa aaagtatata agccaacaat aggggataag cttagggaga
    27661 tagataaaga agatataatt aaaactaata aaattatgta tgcatcttca tttgtatcta
    27721 tgttggtatt tacactaata tatgtgttat gtaggatgat tttaattaac ttaattatat
    27781 aaattattgt ttgttaactt aagggggaca tagatgaagg atttagggca tggtgccaat
    27841 gtagatgaaa tggcaagatt atatgggaaa aacccaaaag aaataattga ttttagttca
    27901 aacataaatc caaatgtatt accaaattta gagagataca ttttaaaagg attagaagag
    27961 tgtaggaatt atccagatat aaattataca aacttgagag aaaatatatc aaaatatata
    28021 gatataaatc cagactttat aatacctggc aatggtgcaa cagaagtgat ttatttgctt
    28081 atgaagagta ttaaaaaaaa attggctata ataaatccga ctttttcaga gtatagaaga
    28141 agtgctgagt taaataattt agatattata gatttagaat tagatttaga aaataacttt
    28201 aaacttaata tagatataat aaaagaaaat ataaaaagat ttgatagttt atttatatgt
    28261 aatcctaata atccgagtgg taatgtccaa gatttaaagg aacttgttca tttactagat
    28321 aaacataata aggtactaat aattgatgaa actttcatgg aatttgttga agatgaaagt
    28381 aaatatagtt tggttaaata tatagaatca aataaaaata tatttataat taaagctgtg
    28441 actaagtttt ttggtatgcc tggtttaagg ctaggatatg gtcttacaag caacactgaa
    28501 attatgaaca aaatttatga acacaaagag ccatggacta tcaattcttt tgcagatata
    28561 ctatccaatt ttatttttga agataaagag tatattaaaa atagtaaaga atattacata
    28621 gaagaaagaa aatatatgtt acaagagttg agaaacataa gaaatataaa ggtctatgat
    28681 acagatgcta attttatctt gataagaata tataaaaaaa caactaaaga attgaaaaaa
    28741 gatttgttta agcaaggaaa catattagtt agagatgcgt ctaattttat aggattagat
    28801 gatagtttta taagagtggc tataaaatct catgaagata acaaaattct tatagaaaat
    28861 atgaaaaatt tattgggtga ttaaaatgaa atcttatgga atatgcccag catcttgtgg
    28921 agaatttgta caaggtataa ttgatgatga agaatattta tgttcatatg caatagatat
    28981 gtattctaaa gtgtatattg aagaaaaatt agtagatata aatttaggga gatataagtc
    29041 aaggttagca attgaaaagg tatttgaaaa atttaattta cctaaaaaat atactaaaaa
    29101 tatttcttta aatataaata gtaaaatacc tgttggaaaa ggaatggcaa gttcaactgc
    29161 tgatatagga gctactataa aggcaacatt atcattgata gataaagatt taagtagcga
    29221 ggagatttct aaattagcag cagaaataga accaacagat tctatattta tagataaaaa
    29281 tagtatattt aatcctctaa atggaactgt tataaaatac ctaggaaatc tgaccaatgc
    29341 gaaagttgta atacttgaac caaacaaagt actagatact atgaagatta gattgaggca
    29401 agattataat aaattaaaag tagagaataa agaagtaata aaaaaatcat ttgctctttt
    29461 agaagaagga ttgaaaaaaa ataatttatc tctagttgga gaggcttgta ctttgagtag
    29521 cttagcaaat gagaatatag aaaaaaaaga gtgtttaaat gaaataataa aaatatcaaa
    29581 aaaatatgga gcatatggag taaatattgc tcacagtgga actgtagtag gtattttaat
    29641 tgataagtct atgaatgata aaaagatgat agatgcctta tgtgaatcta acataaattc
    29701 tgtctataat aaaatttata cacaaaacat aattaatgga ggaattaagg gggaaataga
    29761 atggaataca taaagaatcc tatgaaaata gaagaaaaaa gttttgaatt gatacaagaa
    29821 ataatagacg aaattagacc agattataaa tttaagaata atatcgaaga aaaaataata
    29881 aaaagagcta tacatactac tgctgatttt gattacttag atatattaaa aatatcagaa
    29941 gaagcagttg atagtataat agatgcatta aaaaataatg caagtattta tactgataca
    30001 aatatggctc ttagtggtat aaataaaaga aagttagaat cattaggatg taagtataaa
    30061 tgtttagtgg cagatgatga aactgtaaaa ttagctaaag aaaaaggaat tactcgttct
    30121 atggcagcag tagaaattgc agctaaagaa gaaggaagaa aaatattcgt tttaggtaat
    30181 gctccaacag ctttatataa agttatggag atgaaatcag aaggtagatt agatttagat
    30241 gcagttatag gagttcctgt aggttttgta ggagcacaag aatcaaaaga tgaagttgaa
    30301 aaaacagata taccatatat aatttctaaa ggtagaaaag gtggcagtaa tttagcagca
    30361 gcaatagtaa atgctatatt atatactatg taggtaccta tatggaagaa tatgtatata
    30421 tagatggaaa aaaatataga agaggatata ctacaggttc atgtgcaaca ggtgcatcta
    30481 aggctgctgt atatatgttg attacaaaaa atagaatcaa tactataaat atagatactc
    30541 ctaaggggat accattacta ctaaaagttg ataatataaa tatttctgat acatttgtgg
    30601 aatgttccat aaaaaaagat ggtggagatg atatagatgc aactcatacc atggatattt
    30661 atgcaagagc tgaaattgta gctaaaaatg ataagaacaa agggtatctt actctaaagg
    30721 atatagatag tttaagcacc aatagtgagt gtaaaagtga gctctataag tttattaggg
    30781 tttatggcgg aactggtatt ggtgtggtta cgaaaaaagg gcttagtgtg gatgttggta
    30841 agcctgctat aaatccgact ccacttaaaa tgataaatca tgaaataaga aagcttatag
    30901 gagataattt tgaatctata cttggaaatg ataaagtttt aaaaataaca atctttgctc
    30961 cacaaggaga aactgtagca aaaaaaacat ttaatccaag attaggtata gttggaggaa
    31021 tatctataat aggtacaact gggattgttg aacctatgag tgatgagggt tggaagaagt
    31081 ctctatctat agaacttcag atgaaaaaag aacaaggctt agataaaata atattggttc
    31141 caggaaatca tggagaacag tttataagag aaaaattaaa cttagatatt aagtatgtag
    31201 ttagggtaag taattttata ggctatatga ttaaagaagc tcaaagaata ggatataaga
    31261 aaatcttaat ggcaggtcat ataggtaaat ttataaaagt atctgctggt atttttaata
    31321 ctcatagtaa ggtagcagat gctagaagtg agatattagt ggcaaactta gctttaatgg
    31381 gagctagata cgaattttta aataaaataa atcaatgcgt aactactgaa gaagctgtag
    31441 agctaataaa taatagtgaa tatagagaag tatataatat attaagtaat aaatgtaggg
    31501 agagagtaaa gcaatacttg aatgaagatt cagatgatat tgatgtggaa gtaatcatat
    31561 tttcaatgga taagtcttta ttaggtaaat cggataatac agatgattta gtggaggtct
    31621 ttatatgata aacataatag gtctaggacc tggcaactta gactatataa caaaaaaagg
    31681 tgaaaattta atttccactt ctgatgtatt aattggtggt aaaagaaatt tagagtctat
    31741 aaaaaatttt gaaggagaaa aaatagttct ggattctaat ttaagagaaa ttatagagta
    31801 cataaataac aataaagaaa agcaaatatc aataatagca tctggggacc cattaatata
    31861 tgggataggt agatatctat ctaaaaatat tgataataag atgttaaaca tggtttctgg
    31921 gattagttca ttacagtaca tattttcaaa aatatatgta gatatgaatg atgtatatat
    31981 tacaagtagt catggtaaag taccagattt tgattacata ttatcacata aaaaagtatg
    32041 tatggttaca gattcaaaga taggaccaaa acaaataagt agagaaataa tagatagaaa
    32101 tctaaataaa attattgttg taggagaaaa tctgtcatat gacaatgaaa aaataacaat
    32161 agcaaaacca gaagagataa taagaataga caattttgat atgaatgttg tggtgatttt
    32221 agatgaggaa tagtgaattt ataacaggta aagttccaat tactaaggaa gaggttagag
    32281 caatatcaat aagtaagtta aatttagtaa atgctaaaaa cctcatagac ataggggctg
    32341 gtacaggaag tgtaagtgtt gaagctgcat ataattatcc taatttaaag gttatatcta
    32401 tagagaaaaa tgatgatgct atagagctta tagagaaaaa tataaaaaaa ttcaacttaa
    32461 aaaatataga agtgataaaa ggatgtgctc caattaatct agggttaaat gttaaagttg
    32521 agtctatttt tcttggggga acaggaaata atctggaaga aataatagaa tggtctaaaa
    32581 aaaatctcgt tacaggagga agacttgtag ctaattttat aataatagat acatttaatc
    32641 aaactttaaa actgcttaaa aagcatggat ttaaagaaat agatgtatgt gttttgaatg
    32701 tttctaaact ggagaaacta ggaaaaggtg aatattttaa accactaaat cctatatata
    32761 taatatcttg tgaaaaaggg gaaaatgatg atgaataaag tacattttgt aggagcagga
    32821 cctggagata aagagctgat aacattaaaa ggatacaaat tattaagtaa tgcagatgta
    32881 gtgatatatg caggttcact tgttaatcct gaacttttgg aatactgtaa agaagattgc
    32941 caaatacata atagtgcaca tatggattta caagagataa tagatgttat gagagaaggt
    33001 atagaaaata ataaatctgt tgtaagactg caaacaggtg atttttctat atatggttca
    33061 attagagaac aagtggaaga tttaaataaa ttgaatatag attatgactg tactcctgga
    33121 gtaagttctt ttttaggggc agcatcatct ttaggggttg aatatacagt tccagaaatt
    33181 tctcaaagtg taattataac aagaatggaa ggcagaactc cggttccaga gaaagaatca
    33241 atacaatcat atgctaagca tcagacatct atggtaatat ttttatctgt tcaagaaatt
    33301 gagaaagttg tgtctaaatt actggaaggt ggatatccaa aagatactcc tatagcagtt
    33361 atatacaaag caacttgggc agatgaaaaa atagttaaag gaactttaag tgatatagct
    33421 gtaaaagtta aagaaaacaa cataaataag actgctttaa taatggttgg gagattttta
    33481 ggagaagagt ataataattc aaagttatat gataaggatt tcaaacatga atatagaggg
    33541 taatattgct ataatctgta ttacagaaaa tggaaaaaaa ttagctctaa agataaattc
    33601 tctagtaaat aactgtgtta tatatcaagt aaaaaataaa aaaagtaatt tagttgttga
    33661 agaaacatgt gtacatacag ttcaaaagaa gttaagtgat tttgtaggag aaatatttag
    33721 taaatttgat tacatagtat ttataatggc tacaggtata gttgtacgaa gtatagcacc
    33781 atacataata agtaagttta gtgaccctgc aattttggta atggatgaaa aaggcaaaaa
    33841 cgtaataagt ttattgagtg gtcatattgg aggggcaaac agcttgacac agtacataag
    33901 tagtcttatt gatgctaatc cagtaataac aacagctact gatataaatc aaaaagcttc
    33961 cttagatatg atagcaaaaa aactaaatgc acatattgat aattttagag aaagtgtaaa
    34021 agaagtaaat tctatgctag tgaataataa atgtgttgga ttatatgttg atgaaggata
    34081 tcaagttgat actaggggat ttaaacttat agaaagtaag gatgagttaa gagatagttt
    34141 ttcaaacaca tatatagaaa aattagttgt agtaagcaat aaaataaatt gtattgaaga
    34201 tattgagaat ttaaacctag ataataaatt tgaacattgc tatagtaccc aaaaaataat
    34261 aaaggtaatt ccaagagata tagtgatagg aattggctgt agaagaaaca cagatagtga
    34321 actgatgtat aattcacttg aagagtttct taataaacaa aatatagata ttagagcaat
    34381 aaacacagtt ggaagtatag aactgaaaaa agacgaaaaa gcaataattg aattatcaaa
    34441 aatattgaag gtgccattta aaacattttc agtagatgaa atatctaagg ttgataatct
    34501 ttttgataaa tctgattttg ttaaaaaaaa tgtgggtgtg tattcagtag cagaacctgt
    34561 agcatatctt ttgagcaaag gtaatttgtt agttgaaaaa cataaatata aaggaataac
    34621 tttttcagtg gggagaataa aaatatgata tacgttgtag gaattggacc aggaagtaaa
    34681 gatacaatga ctttagaagc aataaaagca atagaagatt ctgaggctat tgttggatat
    34741 aagacttata taaaactaat agaagaattt atacaaggta aagaaataat ccaaaatggt
    34801 atgaggcaag aagttgatag atgtaaacaa gcagtggagg aagcaaaaaa aggaaaaaaa
    34861 gtagcagttg taagcagtgg tgatgctgga atatatggga tggcaggtct tattttagaa
    34921 ttaatatcta aagaagatga agatataaaa gtaaaggtaa ttccaggcgt tactgcaagt
    34981 attggtgcag cagctatact tggagctcct attatgcatg atttctgtca tataagtttg
    35041 agtgatttaa tgactccgtg ggaagtaatt gaaaaaagat tgagattggc tgctgaagcc
    35101 gattttgtaa tttgtttgta taatccaaga agtaagggaa gaagtgaaca tctaagcaaa
    35161 gcattcaaaa taatgggtga gtttaaaggt ggagatacac ctgttggagt ggtaaaagat
    35221 gtaggtagag aaaaagaaga aaagtttgta tgtacttttg aaaatatgga ctttgaaaaa
    35281 gtcgatatga ctacaatggt tataatagga aataagtcta cctatattaa tggtgaattg
    35341 atgataactc caagaggtta tacagtatga ttttaatttt aggaggaact tcagatagtt
    35401 tatctatatg tgataagata aatgaactga aaaatcaacc atatatcctt tcagttacta
    35461 cagattatgg aagggaactt gcacaacaac atgcagagaa tgtaatttta ggtaagcttg
    35521 gaaaagaaga tatgctaaaa tttataaaag ataataatat agtaaaaata atagatgcca
    35581 ctcatcctta tgcagttgaa gtatccaaaa ctgctattac ttgtgcaaaa ctattgaata
    35641 tagattatat aaggtttgag agaaaatctt taattgaaga aatagattat gataataaat
    35701 ttatagtaga tacaattgaa gaagcctgtg aaatagcaaa taaaataggg acaaatatat
    35761 tcataggaac aggaagtaaa aatttgaaca gatttataga ggaaataagt gataaaaatt
    35821 tagttgttag agttcttcca acgagtgaag tcatattaag ttgtgaaaaa ttaggtttaa
    35881 gtgcagataa tatagtagct atgaaaggtc catttagcca gtatataaat gaagaaacat
    35941 ataaacatta caatatagat ttagtcataa caaaagaaag tggaatagct ggtgggttct
    36001 tagagaaggt aaatgcatgt aaaactttca atataccagt aataattata aaaagagaat
    36061 cgattaacta cgaaaatgta tttaatgaca taaataaaat taaagacata cttgtgtaat
    36121 ttttaggagg agaatatatg aagaaagcct tattagtagt gagttttggt acaagctatc
    36181 atgaaacgag agaaaagaca atagatatat gtgaagataa aataaaaaat tcgttaaaaa
    36241 gccatgattt ttttagagct tatacatcaa atatgataat aaataaaata aaaaaaaggg
    36301 atggaataga aatagataat ccaatacagg ctttagataa aatatatgaa caaggatatg
    36361 atgaagtaat aatccaaaca cttcatatta tatgtggcga agaatttaac aaattaaaag
    36421 aacaagtaga tggatattct tctaaattca aaaagattgt attaggaaga cctttgctta
    36481 cacatattga agattatcag gaagctgtag aggcaattaa gcatcaaatt cctcatatgg
    36541 aaagtaatga agcagtagta tttatgggac atggaacact tcatgaatca cattcagcgt
    36601 atccagcatt ggaatacatg cttagggata atggaataaa tgcttatgtt ggtacagttg
    36661 aagggtatcc agaaatagaa catgtaataa gaagattaaa agaaggaaat ataaaaactg
    36721 taaatttgat gccatttatg ttagttgcag gagaccatgc tataaatgat atggcaggag
    36781 atgaagaaga ttcttggaaa acaatattag aagaaaatgg atttaacgta agagttcatt
    36841 taaaaggact aggagaaaat tcttatatac aagataaatt tgttcgtcat gctgtaaaat
    36901 gtgcagagaa tgcgaagttc tatggtatag gagcagggcc aggagatggt tctttactta
    36961 cgataaaagc ggttaatact ttaaagaaac tggatattct atacactcca gaatcaaaaa
    37021 agggtggaga tagtctagct ttatcaatag ttagtgaata tttacctgaa tcagtggaaa
    37081 taaagtctag gcatttccca atgagttttg atgggaatga aaaaagttta gcttgggaca
    37141 atgtggcaca agaaattata tcagatgtta atgatggtaa aaatgtagga tttgttacat
    37201 taggagaccc tatgatttat agtacatatg tatatataat gaaaagaata ttaggagagg
    37261 tagaagtcga aactatacca ggaatttcat cattttccaa tatagcatct aatcagaatt
    37321 ttccattagt catggataaa gaagctttag tggtaattcc ttgtactatg gaagatgata
    37381 agatagagta tgctttgcaa aattataatt caatagtatt gatgaaagta tataaaaatt
    37441 ttaaagaaat aataaaaaaa ttagaaaagt atgatttaat agaacatgct attttagtaa
    37501 gtaattcttc ccaagaaagc gaaaatgtgt ttacagattt aaaagaagcg caccttgaag
    37561 ataagatatc ttatttttct actatactag taaataaaga taataaaata aaataggtga
    37621 aagcaatatt taaaggagac ttaatatgaa tatagtggtt ggaactaggg gtagtaatct
    37681 agcgcttata caaacagaat gggtaataaa tgaattaaaa aagaagtatc cagaaattag
    37741 ttttgagatt aaaatcataa agacaaaagg agatttaatt caaaatgttt cactggataa
    37801 aataggtgat aaaggattgt ttgtcaaaga aatagagcaa caattattag atggaaaaat
    37861 agacatagca gtacatagta tgaaagatat gccttcttat ttagcagatg gactaaaatt
    37921 tgctcatacg cctaagagag aagacccaag agatgttcta atacttagag aaggatataa
    37981 aaatttagat gatttgcctc atggagcagt aataggaaca ggaagtaaaa gaaggaagtt
    38041 tcaattattg aaacaaagac ctgatttaaa tatagtacaa gttagaggta atgtggaaac
    38101 taggatacga aaaataaaag atgaaaacat gcatggtatt gtgttggcag catcaggaat
    38161 aattagagct aatttacaag ataaaataag ttcttattta cctgttgatg ttgttattcc
    38221 agcacctgcc caaggagctt tagctataga aattagaagc aatgatagta cgatagaggg
    38281 aatagtaaat tcactgaagg atgagaatac agaaatccaa atattggctg aaagaggttt
    38341 tttagatggt gtaaatggaa gttgtcatat tccaatagca gcttattgtg aaataatcca
    38401 agataaaata catcttactg gcttatatgg agattcagaa ggaaaaaaag tagtaatcaa
    38461 gtctatagat ggagatattt cttctcctag agagttaggt ttaaagttag ctaaacttgt
    38521 attgaaggag tatgagaatt atgaagggta aggtttactt agtaggggca ggaccaggtg
    38581 attataaact catgacttta aaaggtttag agtgtataag aaaatcggat gtaatagtat
    38641 atgatagatt agcaaatagt agttatttaa gagaagctaa gcctgattgt gaacttatat
    38701 atgtaggcaa ggcatcaagt aatcatattt tgccacaaga agatataaat agaattatag
    38761 cagaaaaagc taaagaagga aaaattgtaa ctcgtcttaa aggaggagac ccttatgtat
    38821 ttggcagagg gggagaagaa gcagagactt tagtagatga aggtatagaa tttgaagtag
    38881 ttccaggtat aacttctgct ataggaggtt tatgttatgc gggtattcct ataacacata
    38941 gagaccatgc ttcgtcattt catgtaataa caggtcattt gaagggtgat gatagtggag
    39001 aattaaactg gaatgctctt gcaaataaca aaggtactct tgtgtttttg atgggaattt
    39061 caaacctaga gaaaataagt gaaaacttaa tgaaagaagg aaaagataag gatacacctg
    39121 ttgctcttat aagttgggca actagatata atcaaagagt tgttacatct acacttgaaa
    39181 atgtttatga aactgctatt aaagaagaag taaaaccgcc aactcttata gtagttggga
    39241 gtgttgtagg acttagagaa aagttgaact tctttgaaag taagccttta tttggaaaaa
    39301 gtattgctgt aactaggtct agaaatcaaa atagtgtatt ggtagaaaaa ataatggatt
    39361 taggtggaaa tcctatagaa atacctacta ttaaggtaga aaaaatacaa aataatatta
    39421 acttagaaaa tgaaataaaa aatataaata agtataatta tctaatacta actagtaaaa
    39481 atgccgtaga aatcttcttt gaaaagatat atgaaatgaa ttttgattta aggatattat
    39541 ctaatttaaa ggtatgtgct ataggttctg ctacatcaaa tgagttgaaa aaaagaggaa
    39601 ttatagcgga tatagtacca aaaaaatttg tagcagagtc actgtatgaa gagttagcgc
    39661 ctattttaaa tgatgacgat aatatactta tacctagagc agaaaatgct agagattatc
    39721 tagttgacaa acttaaggct atttgtgaag taacagaagt acatatatat agaacagtaa
    39781 tagatgagga gaaaaaaggt gagatattag atattttaaa ttctaatgac atagattata
    39841 taacatttac tagttcctca acagtaaata atcttgttga aattatagga aaagaaaata
    39901 ttaaaatatt agaaaaaata aaaacactat ctataggtcc tataactaca gagacaataa
    39961 atagtttggg aataaaattg tacaaagaat ctgctacatc tactatagat tcgttagtag
    40021 atttaattat aaaaaattaa ttttggaggc ttgaatatgt taagaagacc aagaagacta
    40081 agagcaagta aagcaatcag aaatttggta agagaaacta aggtgaatgt agaagactta
    40141 atatatccac tgtttgtagt agagggggaa aatataaaag aagaaattaa atctttacca
    40201 gatgtctatc atttatcaat agatatgcta gaagacgaaa taaaagaaat aagtgagttg
    40261 ggaattgaac atataatgtt atttggtgtt ccagatgaaa aagatgagtg tgcttcacaa
    40321 gcttttaatg ataatggaat agttcaaaag gcaattagaa aggtaaaaga aataaattca
    40381 gatataaatg taataacaga tgtctgtatg tgccaatata caagtcatgg acattgtggg
    40441 attttaactg atactggtta tgttgataat gataaatcat tggagtattt ggctaaaata
    40501 tctgtaagcc atgctaaagc aggagctgat atggttgctc catctgatat gatggatgga
    40561 agaatacaag caataagaga agctttagat gaaaatggat tagaaaatgt tggaatcatg
    40621 gcttatagtg ttaagtatgc ttcaaattat tatggacctt ttagagaggc agctcattca
    40681 gcaccatctt ttggagatag aaaaacatat caaatggacc cagcaaatag caatgaagct
    40741 ataatagaga ctgaacttga tatattggaa ggtgcagata tacttatggt taaacctgca
    40801 ttatcatatt tagatattat aagaagagtt aaagataatt ttgacttacc tctagcagct
    40861 tataatgtaa gtggagaata ctctatgctt aagtttgctg tgaaggaagg tttattaaat
    40921 gaagatgtaa ttcttgaatc aattacatct ataaaaagag caggagcaga tataataata
    40981 acttattttg ctaaagacat tgctaaactg ttgaaaaaat aaattctagt agtataaaga
    41041 atatcaaaaa gtataggaat tgtaattaac tattatacag tagttttgtt tagacattta
    41101 ttgaagaata atagaaacta atttgcaatt tctatacttt atttatgtaa ctaaataaaa
    41161 tttggaggta gaagatgcta tatcctatta atttaaaatt agatgagtta gatgtagtta
    41221 taattggtgg tggagaagtt gcatatagga aatgtaaaaa tttcttagag tttaacaaaa
    41281 atgttactat agtttctaaa caaattttaa ataaatttta tgatttaaaa ggaaatataa
    41341 aaataataaa agatgattat aaagaaatat atataaaaga tgcttctgta ataattgctg
    41401 ccacaaataa tagagagtta aatatggaaa taggattata ttgtagagca aaaaataagc
    41461 tagtgaatgt agttgataat atagaaatat cgaactttac tgttccatca tatataaaaa
    41521 gaggagattt acttataagt gtgtctactg ggggcaagag tccttcatta tcatcaaaga
    41581 taaaaaaaga aattgaagag agatatactg aagattatga ggagtattta aatgtattag
    41641 gagatataag aaaaaaggtt ataaaaaaat acgaagataa aagtaaaaga aaagatgtgc
    41701 ttaatatgtt ggtaacactt gacctagaag aacttaagaa gtttgatata taaaaaataa
    41761 aataaaaaat gttaaaaagg tgttgacgga t
//
LOCUS       DAEQCW010000025        40799 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.025, whole genome shotgun sequence.
ACCESSION   DAEQCW010000025 DAEQCW010000000
VERSION     DAEQCW010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 40799)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40799)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40799
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.025"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            193..852
                     /gene="cprR"
                     /locus_tag="KRO40_001326"
     CDS             193..852
                     /gene="cprR"
                     /locus_tag="KRO40_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CprR"
                     /protein_id="HBH2092148.1"
                     /translation="MSKILVVDDELDMLKLIENVLKRDGHEVKVISDVEKAMNMDFNY
                     FNLIILDVMMPKMDGFEVCKTIRNKVDCPILFLTAKNMESDIMYGLGIGADDYITKPF
                     GVGELRARITAHLRRESREKKNLLTISNVQFNFLGKEVSIDGKKINFTKSEYLICEFL
                     AKNKGQVFSKERIYESVYGFDGESDISTITEHIKNIRSKLKQYDIYTIETVWGIGYKW
                     V"
     gene            1063..2121
                     /locus_tag="KRO40_001327"
     CDS             1063..2121
                     /locus_tag="KRO40_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH2092149.1"
                     /translation="MDRLKNIRKSLLQYTFLFLLIGITIYLVFKTLDIKMLSNVMVMV
                     DKKFLFIGALAIMCHIMLEGVVMKIIIESTHKVNIRFIGFKLAIMGFYYNLITPFASG
                     SQPVQIYVLKKCKMPLSKASAVVTNKSIIFQIVVTFYCTILVLMNFAMLEKQMKMIMP
                     LVFLGIAINSFVLIMIILVILNPKKIKYFMRITIKHLSKIKFLKFLDNKIESIESFID
                     DYSKAINFFAKNKKVLISTIIVTFIQLSAYFSVSFWIYKAFNLQGYSYIYILTLQAFL
                     YMAISPIPTPGNVGANELAFFTIFKSVFPQPLMGYAVFLYGGFMYYLILIGSGIFTVI
                     THYRMKNRIGRNIVLSEN"
     gene            2372..4516
                     /gene="fdhF"
                     /locus_tag="KRO40_001328"
     CDS             2372..4516
                     /gene="fdhF"
                     /locus_tag="KRO40_001328"
                     /EC_number="1.17.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:2786..2788,aa:Sec)
                     /transl_table=11
                     /product="formate dehydrogenase subunit alpha"
                     /protein_id="HBH2092150.1"
                     /translation="MEKKILTVCPYCGAGCQLYLVVKDNKILRAEPANGRTNQESLCL
                     KGRYGWDFLNDPKILTPRLKKPMIRKQGVLEEVEWDEAINYTASRLNEIKEKYGPDSI
                     MGTGSARGPGNEANYIMQKFMRATIGTNNVDHCARVUHAPSVAGLAYSLGSGAMSNSI
                     PEIENADVLFIFGYNGADSHPIVANRIVKAKKNGAKLIVTDPRVTESARIADIHLPIK
                     GGTNMVLVNAFGNVLIEEGLYNKEFVQNHTQGFDEYKEIVKPYTAKYAEKITGIPEEL
                     IRKAMREYAKGKKAMILYGMGVCQFGQAVDVVKGLASIALLTGNFGRESVGIGPVRGQ
                     NNVQGACDMGALPNVYPGYQNVTDDKIREKFEKAWGVKLSPNNGYSLTQVPDLVLKEK
                     KLKAYYIFGEDPVQSDPDASEVREALDELEFVIVQDIFMNKTALHADVILPATSWGEH
                     EGVYTCADRGFQLMRKAIEPQGDVKPDWQIISEISTAMGYPMNYKNTKEIWDELRQLC
                     PSFLGATYEKIETQGCVQWPCKSESMEDKGTMYLYEGQKFSTPNGKGNLFAAEWRPPM
                     EVEDDEYPFSLCTVREVGHYSVRTMTGNCRTLSSLEDEPGRVQINSNDAEKLGIEDDE
                     LVRISSRRGSVITRATVTDRVKEGATYMTYQWWVGACNELTIANLDPISKTPEYKYCA
                     VKLEKLEDQELAEKCVREEYQSLKDKMTATNI"
     gene            4565..5398
                     /gene="fdhD"
                     /locus_tag="KRO40_001329"
     CDS             4565..5398
                     /gene="fdhD"
                     /locus_tag="KRO40_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate dehydrogenase accessory
                     sulfurtransferase FdhD"
                     /protein_id="HBH2092151.1"
                     /translation="MNNIYSKTKLQENSKDKVFENSYSLVDYKYLNSFNVEVSKINEH
                     EVSIDNEEIIAEYPLSFILNDKYVNTFLCTPYNLEELIVGFLKTKGYIENKKSLLKFE
                     INESERFAKVTIQEKQKNQDEQIIFLNSLDYITCAPVKSNIKINYDTIYSIMDKNLNS
                     SELFKNTGGVHSVSVFNFDKKIVTCEDVARHNAMDKAIGFCVLNDITLKDKIVAVSGR
                     ISLEMILKAAMTQIPIVVSKSAPTNLSIELSKKLNITLIGFVRGRRMNIYANPQRVIK
                     K"
     gene            5409..5582
                     /locus_tag="KRO40_001330"
     CDS             5409..5582
                     /locus_tag="KRO40_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092152.1"
                     /translation="MCTKKEKQRYSKCEICGVLIDDTDKVYNNTYNLCKKCKRNISTE
                     KIVKYINIYDESK"
     gene            5640..6191
                     /locus_tag="KRO40_001331"
     CDS             5640..6191
                     /locus_tag="KRO40_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2092153.1"
                     /translation="MKNKIGSFVIADPNKCTGCRACEVACFTMHNQHNNVGYTVGTVD
                     IPVIPRLYLVKGDNFCMPIQCRHCEDAPCLNSCPQKAIVKENNIMSVNEEKCIGCKTC
                     LLACPFGAIDLLPQYEDGKEVEQVILDENKKIAYKCDLCKDNEKIACISACPQEALKL
                     VTPIDDKKAKNRQAALSLLLTNK"
     gene            6216..7592
                     /locus_tag="KRO40_001332"
     CDS             6216..7592
                     /locus_tag="KRO40_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBH2092154.1"
                     /translation="MIINIDKDLCTGCRECSKVCPVNAIEGEEGKPQEINLDRCVMCG
                     QCVQTCKSYASVIDEGFEFLQEKKQEREIPESINEPIFAAYNVCDIDKVKKALSDPNV
                     FTMVQCAPAVRVALGEDFGYYLGYLGAGKMAAALRALNFDRVYDTNFAADLTIMEEGS
                     ELIKRVTEGGTLPMFTSCCPAWVKFMEKNYPKLTNHLSSCKSPQQMGGAIFKTYGAEI
                     NNVDASKIFSVSIMPCTCKKYECDREEMDSSGYRDVDVVLTTRELAYLIKDMGIDFKN
                     LREEKFDSPLGSYSGAGTIFGVTGGVMEAAIRTGYELITGESIPDVEVKQVRGENGFR
                     KSTIKIGDLDLRVGVVSGLKNVIPVLEDLEKGKLDVDFIEVMTCPVGCVSGGGQPKIL
                     LEEYKELAYENRTKATYVHDEHLAIRKSHENPDIKKLYDEYLVEPLGEKSHHLLHTTY
                     CIGKEVAK"
     gene            7592..8107
                     /locus_tag="KRO40_001333"
     CDS             7592..8107
                     /locus_tag="KRO40_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2092155.1"
                     /translation="MNYFVIADPDKCIGCRTCMIGCVVAHSDEDIFYQNPDEINFNPK
                     LSVIKTKEVSAPIQCRHCEDAPCAKACPNGGIVRVGNTIKINEENCIGCKTCMLACPI
                     GAIDIVTLKDVDEGKLCFRERMTANKCDFCIESPEGPACVNVCPTKAFTIVKDEDIDS
                     KVKNKRKLAIL"
     gene            complement(8185..9468)
                     /locus_tag="KRO40_001334"
     CDS             complement(8185..9468)
                     /locus_tag="KRO40_001334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugated bile salt MFS transporter"
                     /protein_id="HBH2092156.1"
                     /translation="MNTLLNNKFSIKNFSNAWVIVLGCMLIQAVPFSIVASIQPQFIS
                     YVVEGEGFSLASFSLIFTIGTIASAIASPFIGVLFSKVNIKILYLLGCIISSIAFATF
                     SICTELWQFYTVSCIVQIGATIISAIGIPVLISAWFDEESKGKALGFAFAGGSIGSIF
                     LQPLAVRLLATQGYSRSYLIFGIIALIVGIPVILFILRMPKDINEKVKSKGKKEKASD
                     TISPSVWGYTLKEAKKIKYFWIMTIGFIFVGIYVSSLSVQYPTYLRNYLNPILIGTVG
                     STFALFALIGNLFGGLLFDKFGQTKPLIISFVLVLIATLSLLLVDKSSTFAFVFAILK
                     GLSVFAYMIGPAYLTGSFFGQKEFGSIYGIVQLIFAVGFALGSTLFGLLVDNFGYRFS
                     WSIIILSVIIAYTLLIITSIGMKNLNKERLDKLMQ"
     gene            9656..10078
                     /locus_tag="KRO40_001335"
     CDS             9656..10078
                     /locus_tag="KRO40_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3783 domain-containing protein"
                     /protein_id="HBH2092157.1"
                     /translation="MSFEKINNNNLDKIHNRKCIMLVNFNKKELSLIKNVSNFAGIRD
                     HIILSDKNGENIIRDILDGNISNECENGIKSKSVIFNNTPSTQVNAFLEGLKKVRINR
                     PFTAMVTETSIDWTLNNLIENLVQERNAMSLGKTIEHK"
     gene            10180..11118
                     /locus_tag="KRO40_001336"
     CDS             10180..11118
                     /locus_tag="KRO40_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="HBH2092158.1"
                     /translation="MKVLFTINYGKEKFDKIRELGYDVIHYSEDSIENNEDVNTADVL
                     VTYNPFERLDISKMKNLQYIQTTSVGIDQLPKEEVLKRNIKIANNRGGYSVPIGESIV
                     LYILEIYKNSAKFFKQQQNKEWKMDFSVSELYGQRVGFLGTGTISSEAAKRLKAFGVE
                     IWGVNTDGSSKKYFDKCFATEDMNIVFEECDIVVVAMPSTKSTDGIVNKDMFKLMKDG
                     SVFINVGRGNTVNQKDLEECVEKFRGVALDVFESEPLNKDNKLWECENVIVTPHNSWV
                     SDKNKERTFNMVYNNLKHYIMENKPVDNVVDISRGY"
     gene            11304..13328
                     /gene="ligA"
                     /locus_tag="KRO40_001337"
     CDS             11304..13328
                     /gene="ligA"
                     /locus_tag="KRO40_001337"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HBH2092159.1"
                     /translation="MSVKDEINKLIETINYHNERYYNQDSPEISDYEYDKLMKELISL
                     EEEHPELKRIDSPTNRVGGKPLDKFNQIVHKTPMLSLSNAFSEQDLRDFDKRVQEYVG
                     ENVEYVVEFKIDGLSVGLTYNNGEFEKGATRGDGVVGEDISQNLMTVKSIPLKINDKK
                     ELIVRGEVYISKDNFRKVNEQQEEQEQPLFANPRNLAAGSLRQLDPKLTAKRPLDIFV
                     FNMENIEEYDLESHSESLEYLEKLGFSVSQSYKVCKSIDEVIEHIEYWTDNRGNLDYE
                     IDGMVIKVNNIKQRDEMGYTAKSPRWAIAYKFPAEKKKTKIVDIIVEVGRTGTITPSA
                     ILEPVRLAGTTVSRATLHNEDYIREKDIKINDTVLVQKAGDIIPQVLEVIKEERTGDE
                     IDFKMPEKCPVCSEPTIRLEGEAAVKCINMSCPAQIRRGIIHFVSRDAMNIDGLGESI
                     ITLLLNEKIIQDVSDLYYIKKEDVVDLERMGEKSADNLINSIEKSKENDLWRLINGLG
                     IKFIGVKAAKILAYNFKDLDEVISATSEQLEELEEFGSIMANSVVEFFKEDKNMNVIN
                     KLKNVGVNTKSLDNTGEKVEKIFEGMKIVLTGTLPTLKRNDAKDMIEKRGGKATSSVS
                     KSTTFVLAGEEAGSKLTKANDLGIKVIDEERFLELLKLSSKDEVKAVLES"
     gene            13488..14837
                     /gene="rph"
                     /locus_tag="KRO40_001338"
     CDS             13488..14837
                     /gene="rph"
                     /locus_tag="KRO40_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease PH"
                     /protein_id="HBH2092160.1"
                     /translation="MTRSYDRSNEQIRPVKITRDYTKYAEGSVLIEMGETKVICTASV
                     EEKVPPFLRNSGTGWINAEYSMLPRATQQRKIRDASRGKIDGRTQEIQRLIGRAIRSV
                     VDLNKLGERTIWVDCDVIQADGGTRTASITGAFVAVAEAIYKLYKAKTIKEMPITNFV
                     SAISVGIVNGIHMLDLCYEEDSKAQVDMNIIMTDKCEFVEVQGTGEEKPFSRADLNLL
                     LELGEKGNKELIRLQREALGEISDEILGMDYGNEVVIATNNAHKLEEIGEILKDFEYK
                     VYSLKDVDLAGIEIVEDGKTFEHNALIKARTIAKKTKLIAISDDSGLEVDALGKKPGV
                     YSARYAGEHATDEENRKKLLKAMQNIPMSKRNARFVSAIAVVFPDGKEFVVRGICEGM
                     IGFEEKGKNGFGYDSLFIVKGYDKTFGEIPSVIKNSISHRANALKLMKQEFIKRVVK"
     gene            14837..15307
                     /locus_tag="KRO40_001339"
     CDS             14837..15307
                     /locus_tag="KRO40_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2092161.1"
                     /translation="MKIGIVSDTHMMIKNMEKTIPYLKECDLIIHAGDNFTDSRYIHS
                     MTNVGIIAVKGNCDFDAVEEEVVFEVANKTIFLCHGDKYGVKYGTNMLEKKATEVDAD
                     IVIFGHTHTPFREIKDGVLYINPGSTSLPRGVSYKSFVIMDIEEDDIKIEEIRI"
     gene            15501..16787
                     /locus_tag="KRO40_001340"
     CDS             15501..16787
                     /locus_tag="KRO40_001340"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HBH2092162.1"
                     /translation="MKAELIKKEGNKVTLKITVDNNKFEAAVNKAYNKSRNKYNIPGF
                     RKGKAPRIVIETQYGKGIFYNDAIEILFPEVYPEAIKELDIDPIDNPDLDIEEISKDN
                     GLVMVLNVEVKPEFELGNYKGIEIAKVENTVSDENVDAKLQEMVEKNARLVSVEDKAL
                     EDGDTAIIDFEGFENGVAFDGGKGENYNLVIGSNTFIPGFEEQLVGKKAGEEVEVNVT
                     FPEEYHSQDLAGKPVVFNVKINDVKVKELSALDDEFAKDTSEFDSLDELKADVRAKLE
                     EEAKNRADAETRNSVVEKVAENTEIEIPEVMIQHQIDNMLNELNYQLQYQGFGLQQLL
                     EMTGRTMEELREERKEDAKKLVKSSLVLEAITKAEGIEATEEEFKAELEKMASAYNME
                     VEKIEASLRDADKEDIKGQIKIRKTIDLLVDNATIA"
     gene            16937..17521
                     /gene="clpP"
                     /locus_tag="KRO40_001341"
     CDS             16937..17521
                     /gene="clpP"
                     /locus_tag="KRO40_001341"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBH2092163.1"
                     /translation="MALVPVVVEQTGRGERSYDIFSRLLKDRIIFLGDQVNDATAGLI
                     VAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAF
                     LLAAGAKGKRLALPNSEIMIHQPLGGAQGQATDIEIHAKRILKIKETLNEILSERTGQ
                     PLEKIKMDTERDNFMSALEAKEYGLIDEVFTKRP"
     gene            17540..18790
                     /gene="clpX"
                     /locus_tag="KRO40_001342"
     CDS             17540..18790
                     /gene="clpX"
                     /locus_tag="KRO40_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HBH2092164.1"
                     /translation="MSKYEEKRQLKCSFCGKNQDQVRRLIAGPNVYICDECVELCDEI
                     IQEEIEDTIDEDTTSLPKPKEMMEILNDYVIGQEKAKKALSVAVYNHYKRIYSKKSSS
                     KDIEIQKSNILLLGPTGSGKTLLAQTLARTLNVPFAMADATSLTEAGYVGEDVENILL
                     KLIQAADFDIEKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVAN
                     VPPQGGRKHPHQEFLKIDTTNVLFILGGAFDGLEKIIQKRGGDKTLGFGAKIESKKEL
                     DLGKLYEKVLPEDLLKYGIIPEFIGRIPVLATLELLDEDALMQILQEPKNALVKQYKK
                     LLELDDVELEFEEGALRAIAKKAIERNTGARGLRSIVESVMMETMFEVPSRDNIKKVI
                     VTEKSVNEDSVNPIIVLKDQEESA"
     gene            complement(18861..19388)
                     /locus_tag="KRO40_001343"
     CDS             complement(18861..19388)
                     /locus_tag="KRO40_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH2092165.1"
                     /translation="MSEIILLFLIFLKIGAFSFGGGYAMLPFIQQEFISKYHFITNQE
                     FLDLLAISQSTPGPVAINSATFVGFKTAGFFGSLAATIGVTIFALIGLTIISKLFSKF
                     KNNKKVENLLTVLRPITLGFILSAAFSSAKEVNWDLYGIIAFIASFYLLYKGKIGSIA
                     IVFVFGILGILLTFL"
     gene            complement(19376..19888)
                     /locus_tag="KRO40_001344"
     CDS             complement(19376..19888)
                     /locus_tag="KRO40_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH2092166.1"
                     /translation="MLKLFLTFLKIGAFTFGGGYAMVPLIQDELVNKQKLLEQEEFID
                     YLSIAQSYPGVLAVNISVLLGYKLYGIPGVLICTLGSALPSFCIVLVLSYLYFKNSSS
                     KILDGFFKGVAPVVIALILYSFTSMFKKLPKSKTNILLLIIAVLSVGVFNISPIYLII
                     GGGVYSLCQK"
     gene            20068..22431
                     /gene="lon"
                     /locus_tag="KRO40_001345"
     CDS             20068..22431
                     /gene="lon"
                     /locus_tag="KRO40_001345"
                     /EC_number="3.4.21.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase La"
                     /protein_id="HBH2092167.1"
                     /translation="MEQNYTKIDHELPLIPLRGLAIFPYMILNFDIGREISLKALDQA
                     MMDEELIFLTSQKEAEVDEPGEEDFYHVGTICKVKQMIKLPGDTVRVLVEGVSRGRVK
                     KIEQEDGYFRAVIEEIVFDSDNLDSETEVEIEAFVRNVFDAFEEYINIGNRVSPEILI
                     SLADIEDVDRFIDTIAANIYLKSSQKQEILEEFDIRKRLELIYSILLEEIDILKIEKK
                     ITLRVKKQMNKVQKEYYLREQLKAIQKELGEEEDINSEADEYREKLKKIKAPKTTKEK
                     IEKEIDKFSKISSMSPDVSVSRNYLDTIFSLPWNKETKDKLDITKAKDILDEDHYGLE
                     KVKERILEYLAIRTLAKSLKGPIICLVGPPGTGKTSIVKSIARALNRKFVRISLGGVR
                     DEAEIRGHRRTYVGSIPGRIINGVKEAQTKNPVFLFDEIDKMAADYKGDPASAMLEVL
                     DPEQNKDFVDHYLEIPFDLSKILFVTTANSLGNIPRPLLDRMEVIEVSGYIEEEKLNI
                     AKKYLLPKQIKEHALKENFIKIDDETLRSIINHYTREAGVRTLERTIGKICRKVAKKY
                     VEDPTLEEVVINKSDLETYLGKDMFKYQLAEVNPQIGLVNGLAWTEVGGVTLEVEVNV
                     LKGKGEIVLTGKLGDVMKESAKTGISYIRSIVDKFDIDPEFYKTNDIHIHIPEGAVPK
                     DGPSAGITMALAVISALTKRPVPGNIAMTGEITLRGRVLAVGGVKEKLLAAHRAGITK
                     VLIPKECEADLDEIPENVKEKMEFVLVEHMDEVLEQALLKSGENNEN"
     gene            22421..23032
                     /locus_tag="KRO40_001346"
     CDS             22421..23032
                     /locus_tag="KRO40_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HBH2092168.1"
                     /translation="MKIRSSEITMSAVNKSQYPAEGIPEIALAGRSNVGKSSIINTLL
                     NRRNFARTSQTPGKTRTINFYLINNEFYFVDLPGYGYAKIAKSEKEKWGGIMERYLES
                     RQELCSIFLLVDIRHEPTADDKLMYEWIKHFGYNCVVIATKADKISRGQYQKHISIIR
                     KKLQMESSEKVIPVSSLKKTGVEELWEEIVNQYNQHGYEITVD"
     gene            complement(23297..24667)
                     /locus_tag="KRO40_001347"
     CDS             complement(23297..24667)
                     /locus_tag="KRO40_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2092169.1"
                     /translation="MKQKWIVLIIICIGVFMSTLDGSILNIANPTIAADFKINMSQIQ
                     WVVTAYMLVVTATMLFFGKLGDKVGSNRLYTLGFFIFTIGSFLCSMSNNLSTLISSRI
                     FQAVGASILMATGLGIVSNAFPANEKGKAIGITGAVVGIGNMSGPVIGGIILEHFGWP
                     SIFIINIPIGIIAVFLGIKFLPKPVLDEQNKSFDIPGLLLFASCTTLILLAMNEKGNT
                     RLYLGITALIIFLLLALREVKFEQSFIDLPLFKNRNFTVGNIIGVACYFPQMAVSFLL
                     PFYLEQLKNLSPMMAGYVMTVHPLIMVLIAPIAGSLSDKHGAKNILTASFSFMTISLV
                     GMALLKADSPLYLLIVCLVIFGLGLGAFSSPNNSSILADVPPQKQGYGGSFLATIRNL
                     SFALGTAFFSSFFAQSLTYNQKFKSHTSAYVIASNQSYWIAASVCFIGLILTVFFMRK
                     TDKSIS"
     regulatory      complement(24842..24957)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            25245..26324
                     /locus_tag="KRO40_001348"
     CDS             25245..26324
                     /locus_tag="KRO40_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2092170.1"
                     /translation="MEGKVKKAFPGGNTSQGSYSFFDYIIPENVKRVFCLKGGPGVGK
                     SSLMKKIYKEFLHRGYDIDLYHCPSDPSSLDGLVIKKLGVVLMDATAPHTMDPKLPGA
                     LDEIINLGDYWNTEELEKNKQEISVYDKDISNSFKRAFKFLKSAEPIFRDIEEKYSDC
                     MDYGKVNLVTEEFIKRLFDGVKSTGNLKREKHLFGSAITPVGCLDYTENILKDVKKVY
                     YLDGEIGTGKTTLLNKVYKKAIEKGLNVEVYHYPLIPEKIETVLLTDLDIGITISTTF
                     KEEDTIDLNQFLNREKLLKYEEDIKFDEKVLDDLICWAVLNLKRAKSKHDIIESYYSP
                     NMRFDEVGKLRDKLIKRILKYEENL"
     gene            26716..27396
                     /locus_tag="KRO40_001349"
     CDS             26716..27396
                     /locus_tag="KRO40_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBH2092171.1"
                     /translation="MKKQYVFIILTSTILGILVGTIFRDYSNEETVYTSKDKSIRKEI
                     KMTRKSIKELTKEKDKLDKEINSMKQNQKNSEEISEIETLRDSLSYSDVKGSGIILSI
                     DAIDEKTGNIANSIDYNKILVKVINELKVNGGKYIEINGQRINQYSEVVLAGSHININ
                     GVPVAQPYEIKCIGDKEKLSNYVDKGSKYLDSIQTNYPMKISIKTEENISMKKMNIPN
                     KLKYIKGD"
     gene            27389..28768
                     /locus_tag="KRO40_001350"
     CDS             27389..28768
                     /locus_tag="KRO40_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBH2092172.1"
                     /translation="MIKIILEESSLPMLIPEKLAKKYNVFPVEFQDDNLVVEIEDEDI
                     YALQDLRLATGKEIILKKEKKELISEKIEKYYNSFELDEDYAKKLFENLLEKAIKENA
                     SDIHIEPFKEHLIVRMRVDGELKEVSKFLVDVYPSLSTVIKLKASMDITEKRLPQDGR
                     VDIKLGGNLIDIRVSSIPTVYGEKIVLRILNRDTFLKDKLELGFSEEAIKSINRIINK
                     RAGILLVTGPTGSGKTTTVYSLLNDLKGINKNIMTIENPVEYKMDGISQIQVNSKVGL
                     SFDVGLRAILRQDPDIIMVGEIRDAETAKIAVRAAITGHLVISTLHTNDAVSSIARLL
                     EMQIPPYLLNASLIGVISQKLVRKVCNHCSHEIMIKDNFSGDVNTKVAVGCEKCNDKG
                     YFGRTAIYEILEINDDIKTCIRNMEDSSTIKDVAQNNGMITFEDSCKRLINEKITTLE
                     ECLVVNEMI"
     gene            28939..30024
                     /locus_tag="KRO40_001351"
     CDS             28939..30024
                     /locus_tag="KRO40_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBH2092173.1"
                     /translation="MRLSKNIFYNLEKFYLVLNRISDKEIRVICKEIGILLESGCEIT
                     KIFEIIESQSSKKAKNLLSIVSNHIQKGNSIAESFQITGIFSKFFISMIKAGETSGNL
                     DIIMSDLSNYYDKEYKLKMKIITISIYPIILIILSILSMLFIFVFVIPNFQVVFTNNG
                     IEPPLITRVLMGISTVVTNNLAYIIFSFILFSIGSIYFFITNDNIKKLINSLKFKIPF
                     IKKINQLVATTRFSRALSVLISSGIQIVEAIDMSASVIDNEFIYERLKISNNYIKKGN
                     SIGKSLNLANVFPKLFISMANIGEESGKLDKSLNVINKFYENELNNKIEQIMKFIEPM
                     LIVFMGLIIGTFILAMVVPMFDAITNF"
     gene            30078..30437
                     /locus_tag="KRO40_001352"
     CDS             30078..30437
                     /locus_tag="KRO40_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HBH2092174.1"
                     /translation="MINLINKKRKGFTLVEMIVVVTILGVISSIALVKYSKVQESAKL
                     NADYTNAANIVTAASMAINDDEKTIDSLSVETLKEKGYLNTVPVPQSTSGKFELVIND
                     SGTDISVNINSKQFYPK"
     gene            30490..31362
                     /locus_tag="KRO40_001353"
     CDS             30490..31362
                     /locus_tag="KRO40_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pilus assembly protein PilM"
                     /protein_id="HBH2092175.1"
                     /translation="MAIIKKILNLEINDDYIRLVFLRKGHKKVFIDKSIIKEINFDIK
                     NDSNSIEKIKYIEDVVRFVKEEIGKSKILYKNLYFNIQIQDIVIRNVEVLNTKKKRDI
                     LSMIEFEITQYIPININNYSIKYKVINSKNDKLNIQVILFPKSIIQLIKNISENLNMN
                     PKTININFDILQKLINLNLIENFSEEGVFIECKKSQLIINITKDKKIRETYLLSKEGK
                     SYEFIKRLLRDFKYVYYYGIENCFIEEYFKYTDKSIEVNPLRLKDKVKVENNFDADLE
                     DNRINYISNIGMII"
     gene            31363..31806
                     /locus_tag="KRO40_001354"
     CDS             31363..31806
                     /locus_tag="KRO40_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092176.1"
                     /translation="MKVDKTINFLNGFKKTKPCNKIYKIIIVLILTCILFKSFMYVKS
                     INELEDYISQNKLVDKSKNTLPTTDKTREKFSKIKLNEIKKIYETIGINSITKISIDK
                     NKLEMEGVCSDLDVLNNLRKIKYIKYYYIDSIVRDGEYYRFRIKS"
     gene            31821..32405
                     /locus_tag="KRO40_001355"
     CDS             31821..32405
                     /locus_tag="KRO40_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092177.1"
                     /translation="MRLNNREKNLLKILLILVIILASDIAVSYLEENLTSLKNEKQNI
                     INKINNQDNYQIKDNKHIDDKYIESVESNKNEELKNNFNNSFLDKKTNKDIVLLVENE
                     LRDIVNVEYINQESSLDNHNKKQVNLEIKVNGELANVLKLEGVMKKLRLNNKLEKIEI
                     NKLKVNNFDVQNIPNEYKQEKDNIVECKMTVRVI"
     gene            32658..33695
                     /locus_tag="KRO40_001356"
     CDS             32658..33695
                     /locus_tag="KRO40_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBH2092178.1"
                     /translation="MLGRNELCPCGSGKKYKKCCLNKDIVSERACRKTELSQKQYTDL
                     YSKLYDYSRQDKFKEECEKAKEMFYIMQNDSVNEKFERFFNTYLIQDHIMENKKVMTV
                     GFLEENGTNLSQSEVSILKSMFESYVSIYEVKEVSAGKIVLKDCLSGNELCTEDVKLL
                     RSFKIGSCMIARIVDIEGTNILIDITISISNEVKDIILKDIMNLFNQYQDVYKDMKSF
                     LIYHTHILYKYIQQLLDPSIAEYLKRERDKNDTKVNSENELAEEECKVLDTLKENVEK
                     ENIDACIEFWNEYKKNHENIKGAENGWAAAVEYYVKKEAGQPITQVQISKKYDISSST
                     LGKRYKDLKIS"
     gene            33776..34141
                     /locus_tag="KRO40_001357"
     CDS             33776..34141
                     /locus_tag="KRO40_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092179.1"
                     /translation="MSLSLGNAIAVSTNFIKSNPAVPVYNGEEIYAVIYHIEIGYNNG
                     VSPDTKQYIIIDYKEFDLSMDKKNELINIAKEYCKSKGIVENENLEINLLDNEEAENF
                     LEKVFNNMKVIRGLITKKG"
     gene            34146..34463
                     /locus_tag="KRO40_001358"
     CDS             34146..34463
                     /locus_tag="KRO40_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092180.1"
                     /translation="MDYIGIENITPYENTYEFSVYEYDDEITLGSEKLYVCELRVVLI
                     KVNSLYVERLHKSVEAMVLVKNLKKDLDKTLVVNKIKNFVLDEIWVENLVKENIEVIF
                     VES"
     gene            34511..36115
                     /locus_tag="KRO40_001359"
     CDS             34511..36115
                     /locus_tag="KRO40_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092181.1"
                     /translation="MLRVSNVKLGIDKDISLLKDVILKKLKIKEKNLVKYSIYKESID
                     ARKKGKMEFVYSVDVEVKDENKILNSKIKDVTKIKEIRYVNVPVGDKKLKNNPLVIGS
                     GPAGLFAGLLLAQMGYEPIILERGLDVDSRTKDISDFWTTRKLKNNSNVQFGEGGAGT
                     FSDGKLTTRIKDIRCRKVLEELVQFGAPDEILYSHKPHVGTDILKNVVKNIRNEIISL
                     GGQVRFNSKVTDIVVSNDSIQSVIINDTEKIDTDTIILAVGHSARDTYEMLYSRGIKI
                     VQKPFAIGARVEHPQDLINKAQYKDFYNHPRLGAADYRLIEHVSNGRTAYTFCMCPGG
                     SVIASASNDFEIVTNGMSEHARDKINANSAFLVNVTPEDFKSDNSLAGVHFQQKYEKL
                     AFELGGKNYNAPVQLVGDFINNKTSLNLGSVEPSYRPGYTLTNLSECLPSFVTETMRE
                     AFISLDKKLNGFAMYDAVLTGVETRSSSPIRIVRDENTLESVSIKNLYPCGEGAGYAG
                     GIVTAAVDGIKCAEKIIQKYTNNTKI"
     gene            36239..37867
                     /locus_tag="KRO40_001360"
     CDS             36239..37867
                     /locus_tag="KRO40_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBH2092182.1"
                     /translation="MNIIISLMGGLGLFLYGMNLMGEGLQKSAGTKLKKIIKLLTSNL
                     FMGVLVGTGVTAVIQSSSATTVMVVGFVNAGIMTLKQAIGVIMGANIGTTVTAQLVSF
                     DLTGMAPVALGVGIILYLFGNKPRIKNIAEILIGFGILFTGMDFMKMAVEPLRDYQGF
                     TDLLVTFGRYPLLGLLLGFGITAIIQSSSASMGMLVALAAEGLVPLSAALPILYGQNI
                     GTCVTSLLSSIGANKNARRAAMMHLIFNVLGTVIFLIFLNKPVVSMVTSWDPSNVARQ
                     IANTHTLFNIISVLILLPFTNLIIKLAIKLVPDRAGDIDEDETKTIKYIDDRMIETPS
                     IALANTIKEALRMGEKAKESLNASMEALVEHSTEKIDKTYRRERLINDLQKAILNYLL
                     KLSKAPLDDDSREVVDTLFNTVNDIERIGDHAKNIAELSQVAIDSNISFSEEGQSELD
                     VMYNRVVSAYTYALESMRTDNVDLACKVIKIEEQVDIMEKSCRANHMYRLNNNLCSIE
                     NGVIYLDVISNLERISDHAVNIAQQVIAKRLGND"
     gene            38132..39481
                     /locus_tag="KRO40_001361"
     CDS             38132..39481
                     /locus_tag="KRO40_001361"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HBH2092183.1"
                     /translation="MGKINFDYSKATEFFCQNEIDVMQPYVDVAHDMLHNKTGLGNTF
                     LGWIDLPKNYDKEEFDRIKKSAEKIKSDSDVLLVIGIGGSYLGSRAAIDMVSHSFRNG
                     LKKEQRKAPEVYFVGHNISSTYIMDLLDIIEGKDISVNVISKSGTTTEPALAFRIFKD
                     YLEKKYGKEEARKRIYATTDASKGALRQLATEEGYETFVIPDDVGGRFSVLTAVGLLP
                     IAAAGLDIDAMMKGANDAREAFQNPDLKSNDSYRYAVARTILHRKGKDVELLVNYEPQ
                     LHYVSEWWKQLYGESEGKENKGLFPASVDFSTDLHSMGQYIQDGKRLLFETVLNVENC
                     KRNITISSEEVDLDGLNYLAGKTVDFVNHKAFEGTLLAHTDGKVPNLVINIPQLDEYN
                     FGYLVYFFEKACGISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEKEKEELEKRLK"
     gene            39637..40716
                     /locus_tag="KRO40_001362"
     CDS             39637..40716
                     /locus_tag="KRO40_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBH2092184.1"
                     /translation="MSRRKKGISLVILVAIISSILSSFLTIILVKDNLVSKSTGSSTP
                     IVVNDDGKSQNIYQAVAEKATPSVVGITTTSVDTSNMFAIPTETQGVGTGIIVDSNGY
                     ILTNSHVISDGQATSVNVLFNDGSTTSGKVVWFDQQLDLAIVKVDKTGLTPAEFADSD
                     KVKVGDISIAIGNPLGLDFQKTVTQGIISGLDRTIQTEKTNMTGLLQTDASINAGNSG
                     GPLLNQKGQVIGINTAKASQAEGLGFAIPINTAKSIVEEVIKNGKYEKVTLGIKGTDV
                     SNYEAATGTKLSTDKGVYVAEVISGSSAEKAGVKVGDIITKVGDTDITGMNDLNKKLY
                     TFSKGASTKITVNRGGKAVTINVNF"
BASE COUNT        16768 a         4309 c         7352 g        12370 t
ORIGIN      
        1 aagtaaatac gtgtaaaatg aatataaagt ttttgaaata taaagttttt gtatctaaaa
       61 tattttattt gtaaaatagt aattaattat tgtaagctat aatatgagag tattatggtt
      121 aatgtgaatt ttaaagatat tattaaatat ataaattaga atgctattag atggataaat
      181 ggaggagtta ttatgtctaa gatattagta gtagatgatg agttagatat gttaaagttg
      241 attgaaaatg tgttgaaaag agatggacat gaagtaaagg taattagtga tgtagaaaag
      301 gctatgaaca tggattttaa ttattttaat ctaataatat tagatgttat gatgcctaag
      361 atggatggtt ttgaagtatg taaaactata agaaataagg ttgattgtcc aatactgttt
      421 ttgacagcaa aaaatatgga aagtgatatt atgtacggtc ttggtatagg tgcagatgac
      481 tatataacca aaccttttgg tgtaggagaa ttaagggcta ggataactgc tcatttaagg
      541 cgagaaagta gagaaaaaaa gaatttatta actatctcaa atgttcaatt taacttttta
      601 ggcaaagaag tttcaattga tggtaaaaaa attaatttta ctaaaagtga atatctaata
      661 tgtgaatttc tagcaaaaaa taagggacaa gtattttcaa aagaaagaat atatgagtcg
      721 gtatatggtt ttgatggaga aagtgatata agtactatca cagagcatat aaaaaatata
      781 cgaagcaaat taaaacaata tgatatttat acaatagaaa ctgtatgggg gatagggtat
      841 aaatgggtgt aataagtata agtgttgttt agtgaaaata ttatatatat ctacaaaatg
      901 tttgtaaaat attaatctat atattaaaat ttaatttata gattaatatt ttttgtaaat
      961 gacaaaattg taaggtattt tgttataaaa tattaagatt catagtgtat actaataata
     1021 tagtatttag tataaatctt gagcaaagga tggttatttc taatggatag actaaagaat
     1081 attagaaaga gtttactaca gtatacattt ttatttttgt taataggtat aacaatttac
     1141 ctagtgttta aaacattgga tattaaaatg ctatcaaatg ttatggttat ggtagataag
     1201 aagtttttat tcataggtgc tttggcaata atgtgtcaca taatgcttga aggagtagta
     1261 atgaagataa ttatagaaag cactcacaaa gttaatatta gatttattgg ttttaagcta
     1321 gccattatgg gattttatta taatttaata actccttttg cttcaggaag ccaaccagta
     1381 cagatatatg tacttaaaaa atgtaaaatg ccacttagta aggcaagtgc agttgttacc
     1441 aataagtcta ttatcttcca aatagtagtt actttttatt gtacaatact tgttttaatg
     1501 aattttgcta tgttagaaaa acaaatgaaa atgattatgc ctctagtgtt tctagggata
     1561 gccattaatt catttgtctt aattatgata atattagtta ttttaaatcc taaaaaaata
     1621 aaatatttta tgagaattac tataaagcat ttatcaaaaa ttaagttttt aaaattttta
     1681 gataataaga ttgaatccat agaaagtttt atagatgatt atagtaaagc aataaatttt
     1741 tttgcaaaga ataaaaaggt attaatttca actataatag taacttttat tcaattaagt
     1801 gcttacttta gtgtttcatt ttggatatat aaagcattta atttacaagg ttatagctat
     1861 atttatatac tgacattaca agcattttta tatatggcaa tatctccaat accaacacct
     1921 gggaatgtag gagctaatga attagccttt ttcactatat tcaaatcagt attccctcaa
     1981 cctttgatgg gatatgcagt atttttatat ggtggattta tgtactattt gattctgatt
     2041 ggaagtggaa tatttactgt aattactcac tatagaatga aaaatagaat tggcagaaat
     2101 attgttttaa gtgaaaacta aataagttta aagaatatat attgagtata ttaaaaaata
     2161 tgtcataaga actagaatat tttaattaaa tggttgaaat ataaagatta ttatgacata
     2221 ttttttttga aatttaagag gaattgtgag aaaattgttg aatttaatag atagtattgc
     2281 aaaatattta tgattttgca tattataaaa acactcatta tctttaagat aaattttact
     2341 tatcagggga taaatctaag gggggaattg tatggagaaa aaaattttaa cagtttgtcc
     2401 atactgtgga gctggatgcc aattatatct agtagtaaaa gataataaga tattaagagc
     2461 tgaaccggct aatggtagaa caaatcaaga aagtttgtgt ttaaaaggtc gttatggatg
     2521 ggattttcta aatgacccta aaattctaac acctaggcta aaaaagccaa tgataagaaa
     2581 acaaggtgta ctagaagagg ttgaatggga tgaggctata aactatacag cttcaagact
     2641 aaatgaaatt aaagaaaaat atggacctga ttctattatg ggaacaggtt ctgcaagagg
     2701 acctggtaat gaagcaaact atataatgca aaaatttatg agagctacaa taggaactaa
     2761 taatgttgac cattgtgctc gtgtctgaca tgcaccatct gtagccggtc tggcttactc
     2821 attaggtagt ggtgcaatgt ctaattctat accagagata gaaaatgcag atgttttatt
     2881 tatatttgga tataatggag cagattcaca tccaatagtg gcaaatagaa tagtaaaagc
     2941 taaaaaaaat ggtgctaaat taattgttac tgaccctaga gtaactgaat ctgcaagaat
     3001 tgctgatata catctaccta taaaaggtgg aacaaacatg gttttagtaa atgcttttgg
     3061 aaatgtatta atagaagaag gtctttacaa taaagaattt gttcaaaatc atacacaagg
     3121 atttgatgag tataaagaaa ttgttaaacc atatacagct aaatatgctg aaaagattac
     3181 aggaatccca gaagagctta taagaaaagc tatgagagaa tatgcaaaag gtaaaaaagc
     3241 tatgatactt tatggaatgg gtgtctgtca atttggtcaa gctgttgatg tagttaaggg
     3301 acttgcatca attgctctac ttacaggtaa ttttggtaga gaaagcgttg gaataggacc
     3361 tgtacgtgga caaaataatg ttcaaggagc ttgtgatatg ggagctcttc ctaatgtata
     3421 tcctggctat caaaatgtaa ctgatgataa gataagagaa aagtttgaaa aagcttgggg
     3481 ggtaaaatta tctcctaata atggttatag tttaactcaa gttccagact tagtactaaa
     3541 agagaaaaag cttaaagctt attatatatt tggagaagac ccagtgcaaa gtgacccaga
     3601 tgcgtcagaa gttagagaag cattagatga attggaattt gtcattgttc aagatatatt
     3661 tatgaataag acagcacttc atgctgatgt tatacttcca gctacttctt ggggagaaca
     3721 tgagggagta tatacatgtg cagatagagg attccaattg atgagaaaag ctatagagcc
     3781 acaaggagat gtaaaaccag actggcaaat tataagcgaa atttctacag caatgggata
     3841 tcctatgaat tataaaaata ctaaggaaat atgggacgaa cttagacaat tatgtccaag
     3901 tttcttaggt gctacttatg aaaagataga aactcaagga tgcgttcaat ggccttgtaa
     3961 gagtgaaagt atggaagata aaggaactat gtatctgtat gaaggtcaaa agttttctac
     4021 tcctaatggt aaaggtaatt tgttcgctgc tgaatggaga ccccctatgg aagttgaaga
     4081 tgatgaatac ccatttagtt tatgtactgt aagagaagtt ggacactatt cagtaagaac
     4141 aatgactggt aattgtagaa cacttagttc attagaagat gaaccaggac gtgttcaaat
     4201 aaattctaat gatgctgaaa aattaggaat tgaagatgat gaattagtta gaattagttc
     4261 aagaagagga agtgtaataa caagagcaac agttactgat agagttaagg aaggtgcaac
     4321 atatatgact tatcagtggt gggttggagc ttgcaatgaa cttacaatag caaatttaga
     4381 ccctatatct aaaacaccag agtataaata ttgtgctgtt aaacttgaaa aacttgaaga
     4441 ccaagaatta gcagaaaaat gtgtaagaga agagtatcaa agtttgaaag acaaaatgac
     4501 agctacaaat atctaatgat ttatttgatt taagatttat aaaaggcaga aaggctaata
     4561 ttttatgaac aatatatact caaaaactaa attacaagaa aatagtaagg ataaagtttt
     4621 tgaaaatagt tatagtctag tggactacaa atatttaaat tcttttaatg tagaagtaag
     4681 caaaataaat gaacatgaag tatcaataga taatgaagaa ataattgcag aatatccact
     4741 tagttttatt ttaaatgata aatatgtaaa tacattttta tgtaccccat ataatttaga
     4801 ggaacttata gtaggattct tgaaaacaaa aggatacata gaaaacaaaa aaagcttatt
     4861 aaaatttgag ataaatgaga gtgaacgttt tgcaaaagta actattcaag agaaacaaaa
     4921 aaatcaagat gagcaaatta tatttttaaa ttcactagac tatataacct gtgctcctgt
     4981 aaagagcaat ataaaaataa attatgatac gatttacagt ataatggata aaaatttaaa
     5041 ttcatcagaa ttatttaaaa atactggtgg ggtacatagc gtatctgtat ttaattttga
     5101 taaaaaaata gtcacttgtg aagatgtagc aaggcataat gcaatggata aggctattgg
     5161 attttgtgtt ttaaatgaca taacattaaa agataaaatt gtggctgtaa gtggaagaat
     5221 atcattggaa atgatattaa aagcagctat gactcaaatt cctattgtag tatcaaaatc
     5281 agcaccgact aatttatcaa tagagctttc taaaaaatta aatataacgc ttattggatt
     5341 tgtaagagga agacggatga atatttatgc aaatccacag agagttatca aaaagtgaga
     5401 atgaatatat gtgtactaaa aaagaaaagc aaagatattc aaagtgtgaa atctgtggag
     5461 tattaattga tgatactgat aaggtgtata ataacacata caatttgtgc aaaaaatgta
     5521 aacgaaatat aagtactgag aaaatagtga aatatataaa tatatatgat gaaagtaagt
     5581 agacatatga tgaaaataac tagatggttg gaaatataca aattgaaagg tgggataata
     5641 tgaaaaataa aataggctct tttgtaatag cagacccaaa caaatgtaca ggttgtagag
     5701 cttgtgaagt agcttgtttt acaatgcata atcagcataa taatgtgggt tatacagttg
     5761 gaacagttga tatacctgtt atacctagac tttacttagt aaaaggtgac aatttctgta
     5821 tgccaataca gtgtagacat tgtgaagatg ctccttgttt aaactcatgt ccacaaaaag
     5881 ctatagttaa agaaaacaat attatgtctg taaatgaaga aaagtgtata ggatgtaaaa
     5941 cttgtctgct agcatgtcct tttggagcta tagacttact tccacaatat gaagatggta
     6001 aagaagtaga acaagtaatt ttagatgaaa ataagaagat agcttataaa tgtgacttat
     6061 gtaaagacaa tgaaaaaata gcttgtataa gtgcatgtcc tcaggaagca ttaaaacttg
     6121 ttactccaat agatgacaaa aaagctaaga atagacaagc tgcacttagt ttattgttaa
     6181 caaataaata aaggatacag gggtaggtga cgtttatgat aataaatata gataaggatt
     6241 tatgtactgg atgtagagaa tgttcaaagg tctgtccagt aaatgctatt gaaggtgaag
     6301 agggaaagcc acaagagata aatttagata gatgcgttat gtgcggtcaa tgtgttcaaa
     6361 cttgtaaatc ttatgcctca gttatagatg aaggatttga gtttttacaa gagaaaaaac
     6421 aagaaagaga gataccagag tctataaatg aacctatatt tgcagcatac aatgtatgtg
     6481 atatagataa ggtgaagaaa gctttaagtg acccaaatgt attcactatg gtccaatgtg
     6541 caccagcagt tagagttgct ttaggagaag attttggata ttatttagga tacttaggtg
     6601 ctgggaaaat ggcagcagca cttagagctt taaattttga tagagtctac gatactaatt
     6661 ttgcagcaga tttaactata atggaagaag gtagtgaatt aattaaaaga gtgacagaag
     6721 gtggaactct tccaatgttt acatcttgtt gtccagcttg ggtaaaattc atggaaaaaa
     6781 attatcctaa attaactaat catttatctt cttgtaaatc acctcagcag atgggtggtg
     6841 caatatttaa aacttatggt gcagagataa ataatgtaga tgcatcaaag atatttagtg
     6901 tttctataat gccatgtaca tgtaaaaaat atgaatgtga tagagaagaa atggattcta
     6961 gtggatatag agatgtagat gtagtattaa ctactagaga actagcttat ttaataaaag
     7021 acatgggaat tgattttaaa aatttaagag aagaaaaatt tgatagtcct ttaggtagtt
     7081 atagtggagc tggaactatc tttggtgtta ctggtggggt tatggaagct gctataagaa
     7141 caggatatga gcttataact ggagaaagta ttcctgatgt agaagtaaaa caagtaagag
     7201 gagaaaatgg ttttagaaag tcaactatta aaataggaga cttagactta agagttggag
     7261 tagtaagtgg attaaaaaat gtaataccag tgcttgaaga cttggaaaaa ggaaaattag
     7321 atgtagattt tattgaagtt atgacttgtc ctgttgggtg tgtaagtggt ggaggtcaac
     7381 caaaaatttt actagaagaa tataaggaat tggcttatga aaatagaaca aaagcaacat
     7441 acgtgcatga tgaacattta gcaattagaa aatctcatga gaatcctgat attaaaaaac
     7501 tgtatgatga atatctggta gaaccattag gagaaaaatc tcatcatcta ttacacacta
     7561 catattgtat aggaaaggaa gtggctaagt gatgaactat tttgttatag cagaccctga
     7621 taaatgcata ggatgtagaa cttgtatgat aggatgtgta gttgcacatt cagatgaaga
     7681 tattttttac caaaatccag atgaaataaa ttttaatcca aaactttctg tcataaagac
     7741 aaaagaagta agtgctccaa tacagtgtag acattgtgaa gatgctcctt gtgcaaaggc
     7801 atgtccaaat ggtggtatag ttagggttgg taacacaata aaaatcaatg aagaaaattg
     7861 tataggatgt aagacttgta tgttagcatg tcctataggt gcaatagaca tagttacatt
     7921 aaaagatgta gatgaaggaa agctttgctt tagagaaaga atgacagcaa ataagtgtga
     7981 tttttgtata gaatcgccag aagggcctgc atgtgtaaat gtttgtccaa ctaaggcatt
     8041 tactatagtt aaggatgagg atatagatag taaagttaaa aataagagaa aattagctat
     8101 attgtaatat aaaaaagatg gagttttatt tatgattaaa agctccatct tttttattat
     8161 aatatttata tatctaaaaa tcaattattg cattagttta tctaatcttt ctttattcaa
     8221 atttttcatt cctatagaag ttataataag taaagtatag gcaattataa ctgataaaat
     8281 tataatagac caagaaaatc tgtatccaaa attatcaact aacaatccaa ataatgttga
     8341 acctaatgca aatcccactg caaaaattaa ttgtacgatt ccatatatgc taccaaactc
     8401 cttttgacca aagaaagagc cagttaaata agcaggacca atcatataag caaatacaga
     8461 aagacctttc aaaatggcaa atacaaatgc aaaagtagaa gatttatcta ccaatagtaa
     8521 tgataaagtt gctataagaa ccaatacaaa agatataata agtggctttg tttgaccgaa
     8581 tttatcaaac aataatcctc caaataaatt accaatgaga gcaaataaag caaatgtgga
     8641 gcctactgtt cctattagaa taggatttag ataatttcta agataagttg gatattgtac
     8701 agataatgat gaaacatata taccaacaaa tataaatcca atagtcataa tccaaaaata
     8761 tttaattttt ttagcttctt ttaatgtata accccatact gaaggagaaa ttgtatcaga
     8821 tgctttctct tttttacctt tagattttac cttttcatta atatctttag gcatcctgag
     8881 tataaataat attacaggta taccaactat taatgctata attccaaata ttagataaga
     8941 acgactgtat ccttgagttg ctaataagcg aactgcaagt ggttgtagaa atatactacc
     9001 aatagaacca ccagcaaaag caaagcccaa agcttttcct ttgctttctt catcaaacca
     9061 agcacttatt aaaacaggta ttcctatagc agatataatt gtagcgccaa tttgaacaat
     9121 acatgataca gtgtaaaatt gccatagttc agtacatata gaaaaagtag caaaagcaat
     9181 actagaaatt atacaaccta ataaatatag tatcttaata ttgactttag aaaataatac
     9241 acctataaaa ggtgatgcaa ttgctgaggc aatagtacca atagtgaata ttagagaaaa
     9301 agaagctaaa ctaaagcctt ctccttctac aacataactt ataaattgag gctgtatact
     9361 tgctacaata ctaaatggaa cagcttgtat caacatacaa ccaagtacta taacccaagc
     9421 atttgaaaag tttttaatgc taaatttatt gtttagtaat gtattcatgg tatctctcct
     9481 ttaggttatg atttgtagat attaatctaa ttattctaat tttatatatt agttttggat
     9541 agcctaacta tttaaatata atttgggtat taatataaaa attaactata aaaattgatt
     9601 attttaaatg tatggggtaa attaaagtat ataaataaat gaaaggatgg ataaaatgtc
     9661 atttgaaaaa ataaataata ataacctaga taaaatacac aacaggaagt gtattatgct
     9721 tgtaaacttt aataaaaaag aattatcatt aattaaaaac gtaagtaact ttgctggaat
     9781 aagagaccat atcatcttaa gtgataaaaa tggagagaat ataataagag acattttaga
     9841 tggaaatata tcaaatgaat gtgaaaatgg gattaagagt aagtctgtaa tatttaataa
     9901 cactccaagc acacaagtaa atgcattttt agaagggcta aaaaaagtga gaataaatag
     9961 accttttaca gctatggtaa cagagacatc tattgattgg acattgaata atttaataga
    10021 aaatttagtt caagaacgta atgctatgtc tttaggaaaa acaattgaac ataagtaaat
    10081 ttaagatatc ttatagtaat tttaactaat gtacattgag tatcatatta tattttagaa
    10141 tataaaattt taaatgtggg tagatggagg agatttgaga tgaaagtttt atttacaata
    10201 aattatggaa aagaaaaatt tgataaaata agagaattag gctatgatgt catacattac
    10261 tctgaagata gtattgaaaa taatgaggat gtaaatacag cagatgtact agttacatac
    10321 aatccatttg agagattaga tatttctaag atgaaaaatt tacaatatat acagacaact
    10381 agtgtaggta tagaccaact tccaaaagaa gaggtattga agagaaatat taagatagct
    10441 aataatagag gtggatatag tgtacctatt ggtgaaagta ttgtattgta tattttagaa
    10501 atatataaaa atagtgcaaa attttttaaa caacaacaaa ataaagaatg gaagatggat
    10561 ttttctgtat cagaattgta tggacaaaga gttggatttt taggaacagg tactatatct
    10621 tcagaagcag caaaaagatt aaaagctttt ggtgtagaaa tatggggtgt caatactgat
    10681 ggaagtagta aaaaatactt tgataagtgt tttgctactg aggatatgaa tattgtattt
    10741 gaagaatgtg atatagtagt tgtagcaatg ccttctacaa aaagtacaga tggaatagta
    10801 aacaaagata tgtttaaact tatgaaagat ggttctgtat ttataaatgt aggtagagga
    10861 aatacagtta atcagaaaga tttagaagaa tgtgtagaga aatttagagg ggtagcatta
    10921 gacgtatttg aaagtgaacc tttaaacaag gacaataagt tgtgggagtg cgaaaatgtc
    10981 atagtaactc ctcataattc ttgggtgtca gataaaaaca aagagagaac atttaatatg
    11041 gtttataata atttgaaaca ctatataatg gagaataaac ctgtagataa tgttgtagac
    11101 atatcaagag gctattaaaa ataaaaaatt ttgataaaaa taaaaactct tattagtcgt
    11161 attaaagata ctaataagag ttttttttgt aataaattta aagccaaaaa agtgatatac
    11221 taaaaaatat ataaatagga gataattaat tatagggaaa tttcaaaata atttaatttt
    11281 aaaaatatga agaggtgcaa aaagtgagcg taaaagatga aattaataaa cttatagaga
    11341 caataaacta ccataatgaa aggtattata atcaagatag cccagaaata tcagattatg
    11401 aatacgataa gttaatgaag gagttaattt ctttagaaga agaacatcca gaactaaaga
    11461 gaattgattc tccaacaaat agggtaggag gtaagccatt agataagttc aatcaaattg
    11521 tacataaaac tcctatgttg agtttatcaa atgctttttc agagcaagat ttgagagatt
    11581 ttgataagag agttcaagaa tatgtgggag aaaatgttga atatgttgtt gaatttaaaa
    11641 tagatggtct ttctgtaggt ctaacttata acaatggaga gtttgaaaaa ggagcaacta
    11701 gaggagatgg agttgtagga gaagatattt ctcaaaactt aatgacagta aaaagcatac
    11761 ctcttaagat aaatgataaa aaagaactaa tagttagagg agaagtatat atatcaaaag
    11821 ataattttag aaaagtaaat gaacaacaag aagaacaaga acagccatta tttgctaatc
    11881 caaggaatct tgcagctggt tcattgagac aattagaccc aaaactaaca gcaaagagac
    11941 cattagatat atttgtattt aatatggaaa atatagaaga atacgattta gaaagtcaca
    12001 gtgaatcact agagtactta gaaaaactag gattttcagt aagtcagagt tacaaagttt
    12061 gtaaaagtat agatgaagtt attgagcata ttgaatactg gacagataac aggggtaatt
    12121 tagactacga aatagatggt atggtaataa aagtaaacaa tataaaacaa agagacgaaa
    12181 tgggatatac agccaaaagt cctagatggg caattgcata taaattccca gcagaaaaga
    12241 agaaaactaa aatagtagat ataatagtag aagttgggag aactggtaca ataacacctt
    12301 cagcaattct tgaaccagtc agacttgcag gtactactgt aagtagagct acacttcaca
    12361 atgaagatta tataagagaa aaagatataa aaataaatga tacagtatta gttcaaaaag
    12421 caggggacat aatacctcaa gttttagaag ttataaaaga agaacgtact ggagatgaaa
    12481 tagattttaa aatgccagaa aagtgtccag tttgttcaga gccaacaata agattagaag
    12541 gagaggctgc tgtaaaatgt atcaatatgt cttgcccagc ccaaataaga aggggaatta
    12601 tacactttgt gtcaagggat gcaatgaata tagatggatt gggagaatct ataattacac
    12661 tgctattaaa tgaaaaaatt attcaagatg tatctgattt atattatata aaaaaggaag
    12721 atgtagtcga cctagagaga atgggcgaaa aatctgctga caatttaata aattcaattg
    12781 aaaaatcaaa agaaaatgat ttatggagac ttataaatgg attaggtatt aaatttatag
    12841 gagttaaagc agctaagata cttgcatata actttaagga tttagatgaa gtaatttctg
    12901 caactagtga gcaactagaa gaattagagg aatttggaag tataatggca aacagcgttg
    12961 tcgagttttt taaggaagac aaaaatatga acgttataaa caagttaaaa aatgtaggag
    13021 taaatacaaa atcattggat aatacaggtg aaaaagtaga aaaaatattt gaagggatga
    13081 aaatcgtatt gactggtaca cttcctacat taaaaagaaa tgatgcaaaa gatatgatag
    13141 aaaaaagagg tggaaaagct acatctagtg ttagtaaatc gacaacattt gttttggcag
    13201 gtgaagaagc tggttctaaa cttactaaag caaatgattt aggaattaaa gttatagatg
    13261 aagagagatt tttagaatta ttaaagttat catcgaaaga tgaagtaaaa gctgtattag
    13321 agagttaaaa agtcgcttaa tttagtagaa aactactata attaatgata gaatagttca
    13381 gtaagctaat aagattacga aaaatgacaa taattaatat ttgacaaaat taaaaattat
    13441 aaaaataaat ttataaaaaa taaaaaatat gagaaaggat ataaaaaatg accagaagtt
    13501 atgatagaag taatgaacag ataagacctg taaagataac tagagattat acaaagtatg
    13561 cagaaggttc tgttcttata gaaatgggag agacaaaggt tatatgcact gcatcagtgg
    13621 aagaaaaagt tcctcctttt ttaagaaata gtggtactgg atggataaat gctgaatatt
    13681 ctatgctacc aagagcaaca caacaaagaa agataagaga tgcatctagg ggaaaaattg
    13741 atggaagaac acaagaaata cagaggttaa taggaagagc aataaggtct gttgtagact
    13801 tgaataaatt aggagaaaga actatttggg tagattgtga tgtgattcag gcagatggtg
    13861 gaactagaac tgcatctata acaggggcat ttgtagcagt tgcagaagca atatataaat
    13921 tatataaagc aaagacaata aaagagatgc caataacaaa ttttgtgtct gcaattagtg
    13981 ttggtattgt aaatggaata cacatgctag atttatgtta tgaagaagat tctaaagcac
    14041 aggtagatat gaatataata atgactgata agtgtgagtt tgtagaagta caggggacag
    14101 gagaagagaa acctttttcg agagcagatt taaatttatt gttagagtta ggtgaaaaag
    14161 ggaataaaga attaataagg cttcaaagag aagctttagg tgaaatatca gatgagatat
    14221 tgggtatgga ttatggtaat gaagtagtga ttgctactaa taatgctcat aagctagaag
    14281 aaataggtga aatcttaaaa gattttgaat ataaagtgta ctctttaaaa gatgttgatt
    14341 tagcaggtat agagatagta gaagatggaa aaacatttga gcataatgcg ttgataaaag
    14401 ctagaacaat agcaaaaaag actaaactta tagcaatatc agatgattct ggcttagaag
    14461 tagatgcttt aggcaaaaaa cctggtgttt attcagctag atatgcagga gaacatgcaa
    14521 cagatgaaga aaatagaaaa aaactgttaa aagctatgca aaatatacca atgagcaaaa
    14581 gaaatgcaag attcgtctct gcaatagcag tagtttttcc tgatggaaaa gaatttgtag
    14641 taagaggaat ttgtgaagga atgataggat ttgaagaaaa aggtaaaaat ggttttggat
    14701 atgatagctt atttatagta aaaggatatg ataagacttt tggtgaaata cctagtgtta
    14761 taaaaaattc aatcagtcat agagcaaacg cactaaaact tatgaaacaa gagtttataa
    14821 aaagggtagt gaagtaatga aaataggcat agtaagcgac acacatatga tgattaaaaa
    14881 tatggaaaaa acaataccat atttgaaaga atgtgaccta ataattcatg caggagataa
    14941 ctttactgat tcaagatata ttcatagcat gactaatgta ggtattattg cagttaaagg
    15001 taattgtgac tttgatgctg ttgaggaaga agttgtcttt gaagtggcaa ataaaaccat
    15061 attcttatgc catggagata agtatggtgt aaaatatgga actaatatgt tagaaaaaaa
    15121 ggcaactgaa gttgatgctg atatagttat atttggccat acccataccc catttagaga
    15181 aattaaagat ggtgtacttt acataaatcc tggaagcact tcacttccaa gaggagtatc
    15241 gtataaaagt tttgtcatta tggatataga agaagatgac ataaaaattg aagaaatacg
    15301 catataaagg tgtatttatc taaaaaaatg gcaaaaaacg ctcaaaaaat taaattttat
    15361 caaataagta caacgatatt aatggaacac ttgtaaataa aaaaacttat gtgatataat
    15421 taagtggttg aattataaat agaatgaatt ataataccgt tatcgggtat tacataaata
    15481 tcactaggag gattagaagg atgaaagcag aactaattaa aaaagagggt aataaagtta
    15541 ctttaaaaat aacagtagat aacaataaat ttgaagcagc agtaaataag gcttataata
    15601 aaagcagaaa taaatacaat atacctggat ttagaaaagg taaagctcca agaattgtta
    15661 tagagactca atacggaaaa ggtatattct acaatgatgc tatagaaata ttattcccag
    15721 aagtttatcc agaagctatc aaggaattag acatagaccc aatagacaat ccagatttag
    15781 atatagaaga aataagtaaa gacaatgggt tggttatggt tcttaatgta gaagttaaac
    15841 cagagtttga attaggaaac tacaagggta tagaaatagc taaggttgag aatactgtaa
    15901 gtgacgaaaa tgttgatgct aaactacaag aaatggttga aaaaaatgcc agattagtaa
    15961 gtgtagaaga caaagcttta gaagatggag atacagctat aatagacttc gaaggttttg
    16021 aaaatggtgt agcttttgat ggtggtaaag gtgaaaatta taacttagtt ataggttcaa
    16081 acacatttat accaggattt gaagaacaat tagtaggtaa aaaagctggt gaagaagtag
    16141 aagttaatgt tactttccca gaagaatatc actcacaaga tttagctgga aaaccagttg
    16201 tatttaatgt aaaaataaat gatgtaaaag taaaagaatt atctgcactt gatgatgaat
    16261 ttgctaaaga tactagtgaa tttgattctt tagatgaatt aaaagcagat gtaagagcta
    16321 agttagaaga agaagctaaa aatagagcag atgcagaaac tagaaattca gtagtagaaa
    16381 aagttgctga aaatacagaa atagaaatac cagaagttat gatacaacat caaatagata
    16441 atatgttaaa tgaacttaac taccaattac aatatcaagg atttggatta caacaattac
    16501 tagagatgac tggtagaact atggaagaat taagagaaga gagaaaagaa gatgctaaaa
    16561 aattagttaa gtcttcttta gtattagaag caataactaa agctgaagga attgaagcaa
    16621 cagaagaaga atttaaggct gagttagaaa aaatggcttc tgcttacaat atggaagtag
    16681 aaaaaataga agcttcttta agagatgctg acaaagaaga tataaaaggt caaataaaaa
    16741 taagaaaaac aatagattta ttagttgata atgcaacaat agcttaataa aataaacgct
    16801 aactaatata gttgacgtta tgaaatgttt agtatataat gatgtgcaaa tataatttag
    16861 ttaaatgcgt ataataattt acagtagctt aaaaaaagct actgtaaatt atatagaata
    16921 aagggggtat gaaaccatgg cattagtacc tgtagttgtt gaacaaacag gaagaggaga
    16981 aagatcttat gatatttttt ctagactatt aaaagacaga ataatcttct taggagatca
    17041 agttaacgat gccacagcag ggcttatagt agcacagcta ttatttttag aagctgaaga
    17101 cccagacaaa gatatacatt tatatataaa ttctccagga ggaagtataa cttctggaat
    17161 ggctatatat gatactatgc aatacatcaa accagatgta agtactatat gtataggtat
    17221 ggctgcttct atgggagcat tcttgttggc agcaggagca aaaggaaaaa gactagcact
    17281 accaaatagt gaaataatga tacatcaacc attaggtgga gctcaaggtc aagcaacaga
    17341 tatagaaatt catgcaaaga gaattttaaa aataaaagaa actttaaatg agatattatc
    17401 tgaaagaact ggtcagccat tagaaaaaat taaaatggat actgaacgtg ataacttcat
    17461 gagtgcacta gaagccaaag aatatggttt aatagatgaa gtatttacaa agagaccgta
    17521 gatagagaga ggtgttaata tgtctaaata tgaagaaaaa cgacaattaa agtgttcatt
    17581 ctgcggtaaa aatcaagatc aagtaagaag attaattgca ggtccaaatg tatatatttg
    17641 tgacgagtgt gttgaacttt gtgacgaaat tattcaagaa gagatagaag atactataga
    17701 tgaggatact acatctttac caaaaccaaa ggaaatgatg gagattctaa atgattatgt
    17761 aataggtcaa gaaaaagcta aaaaagcttt atcagttgcg gtttataatc attataagag
    17821 aatatacagt aaaaaatcta gtagtaagga tatagaaatt caaaagagta atatactttt
    17881 attaggacct acaggttctg gaaagacatt acttgctcaa actctagcaa gaactctaaa
    17941 tgtacctttt gcaatggcag atgctacatc attgactgaa gctggatatg ttggagaaga
    18001 cgttgaaaat atacttttaa aacttattca agctgctgat tttgatatag aaaaagctga
    18061 aagaggtata atatatatag atgagataga taagattgca agaaaatctg aaaacccatc
    18121 tataactaga gatgttagtg gtgaaggtgt tcaacaagca cttctaaaaa tattagaagg
    18181 tactgttgca aatgttccac cacaaggagg aagaaaacat cctcatcaag aatttttaaa
    18241 gatagatact actaatgtat tatttatatt aggtggagct tttgatggat tagagaagat
    18301 aattcaaaaa cgtggtggag ataaaacact aggttttgga gctaaaatag aaagtaaaaa
    18361 agaattagat ttagggaagc tatatgaaaa agtacttcca gaggatttat taaaatatgg
    18421 tataatacca gagtttatag gaagaatacc agttttagct actttagagt tgttggatga
    18481 agatgcatta atgcagatat tacaggaacc taaaaatgct ctagtaaaac agtataaaaa
    18541 gttattggag ttagatgatg ttgagctaga atttgaagaa ggtgctcttc gtgcaatcgc
    18601 taaaaaggcc atagaaagaa atacaggagc tagaggactt agaagtatag ttgaaagcgt
    18661 aatgatggaa actatgtttg aagtaccatc tagagataat ataaagaagg ttatagtaac
    18721 agagaaatct gtgaacgaag actcagtaaa tcctatcata gtacttaagg atcaagagga
    18781 aagtgcataa gatgatgaaa aggagcttta aaagctcctt tttttatgtt aatatgctaa
    18841 atataaaata ggtatcatta ttataaaaat gtgagtaata tacctagaat accaaagacg
    18901 aatacaattg caatggaacc aatttttcct ttatataaaa gataaaatga tgctataaat
    18961 gcaattattc catataaatc ccaattaact tctttggcag atgaaaaagc tgctgataat
    19021 atgaatccta gagtaattgg tctaagaact gtcaataagt tttctacctt tttattattt
    19081 ttaaatttag aaaataactt tgatataata gttagaccta ttaatgcaaa aattgtaaca
    19141 ccaatagttg cagctagaga accaaagaag ccagcagtct taaatcctac aaatgtagca
    19201 ctatttattg ctacaggacc tggtgtagat tgtgatatag caagtaaatc caaaaactct
    19261 tgattagtta taaagtgata tttagatata aattcttgct ggataaatgg tagcatggca
    19321 taaccgccac caaaactaaa tgcccctatt ttaaggaata ttaagaagag tagtattatt
    19381 tctgacatag actatataca cctcctccaa ttattaaata aatagggctt atattgaata
    19441 caccaacaga taaaactgct ataattaata gtagtatgtt agttttagac tttggtagtt
    19501 tcttgaacat gctcgtaaaa gaatacaata taagagctat tacaacaggc gcaactcctt
    19561 taaaaaatcc atctaaaatt ttagatgatg aatttttaaa gtatagatac gataagacta
    19621 agactataca aaatgatggt aaagcagagc ctaaggtaca tataagaact cctggtatac
    19681 cataaagttt atatcctaat aatacagata tattaactgc cagtactcca ggataacttt
    19741 gagctatgga taaataatca ataaattctt cctgctctaa aagtttttgt ttgtttacaa
    19801 gttcatcttg tataagagga accatagcgt atccaccacc aaatgtaaac gcaccaattt
    19861 ttaaaaaggt taaaaacaat ttcaacataa tagaaacctc caaaagataa ataacatcta
    19921 agtatactaa tattaatatt atatcataat aaaaagataa tatagtatga tagtattcta
    19981 agaatttatc attaatgttg aaaattaact tgttcaaata tataatatta aaagcaaagc
    20041 aattagacta gaaaaggagt aatgttgatg gaacaaaatt atactaaaat agatcatgaa
    20101 ttaccattaa ttcctctaag aggattagct atatttccat atatgatatt aaattttgat
    20161 ataggtagag agatatctct taaagcttta gaccaagcta tgatggatga agaacttata
    20221 tttttaactt ctcagaaaga agcagaggta gatgagccag gagaagagga tttttatcat
    20281 gtgggaacaa tctgtaaagt taagcaaatg ataaaattac caggagatac agttcgtgtt
    20341 ttggttgaag gtgtatcaag gggtagagta aagaaaatag aacaagaaga tgggtatttc
    20401 agagcagtaa tagaagaaat agtatttgat agtgataatt tggatagtga aacagaagtt
    20461 gaaattgaag catttgtaag aaatgtattt gatgcctttg aagagtatat aaatattgga
    20521 aatagggtat caccagaaat attaatatct ttagctgata tagaagatgt agatagattt
    20581 atagatacga tagctgcaaa catatatcta aaatcaagcc aaaaacaaga aatattagaa
    20641 gaatttgata ttagaaaaag acttgaactt atttattcta tattattaga ggaaatagat
    20701 atattaaaaa tagaaaagaa aataacttta agagtaaaaa aacagatgaa taaggttcaa
    20761 aaagaatatt atcttagaga acaattaaaa gctatacaga aagaattagg tgaagaagaa
    20821 gatataaact ctgaagcaga tgagtataga gaaaagctta aaaaaataaa agcacctaag
    20881 acaactaaag agaaaataga aaaagagata gataaatttt caaaaatatc ttctatgtct
    20941 ccagatgtat ctgtaagtag aaactattta gatactatat tctcattgcc atggaataaa
    21001 gagacaaaag ataaattaga tataactaag gcaaaagata tattagatga agaccattat
    21061 ggattagaaa aagttaagga gagaatacta gagtatctag ctataagaac tcttgctaag
    21121 tcacttaaag ggcctataat atgtctagtt ggtcctccag gaacaggaaa gacatctata
    21181 gtaaaatcaa tcgccagagc attaaataga aaatttgtaa gaatatcttt gggtggagtt
    21241 agagatgaag cagaaataag aggtcataga agaacttatg taggttcaat tccaggaaga
    21301 ataattaatg gggtaaaaga agcccaaaca aaaaatcctg tattcttatt tgatgagata
    21361 gataagatgg cagcagatta taaaggtgac ccagcttcag caatgctaga agtattagac
    21421 ccagagcaaa ataaggattt tgtggaccat tacttagaaa taccttttga tttatcaaaa
    21481 atactatttg ttacaacagc aaatagtcta ggtaatatac caagaccatt attagataga
    21541 atggaagtaa tagaagtatc tggatatata gaagaagaaa aattaaatat agcaaaaaaa
    21601 tacctacttc caaaacagat taaagaacat gctttaaaag aaaactttat aaaaatagat
    21661 gatgaaactt taagaagtat aatcaaccat tatacaagag aagcaggtgt aagaacacta
    21721 gaaagaacta ttggtaagat ttgtagaaag gttgccaaaa aatacgttga agacccaact
    21781 cttgaagagg ttgttataaa taagtctgac ctagagacat atcttggaaa agacatgttt
    21841 aagtatcaac ttgcagaagt taaccctcaa ataggattag taaatggtct tgcgtggaca
    21901 gaagttggtg gagttacact tgaagtagaa gtaaacgtac ttaaaggtaa aggcgaaatt
    21961 gtattaactg gaaaattagg agatgttatg aaggaatctg cgaagacagg tatctcttat
    22021 ataaggtcaa tagtggacaa gtttgatata gaccctgaat tttataagac gaatgatatt
    22081 catatacaca ttccagaagg tgctgttcca aaagatggac catcagctgg tataactatg
    22141 gctcttgcag taatctcagc acttactaaa agacctgtgc ctggaaatat agcaatgaca
    22201 ggagagataa ctttaagagg tagagtctta gcagtaggag gagttaaaga aaagttatta
    22261 gcagctcata gagctggtat aacaaaagta ttaattccta aagaatgtga agctgattta
    22321 gatgaaatac cagaaaatgt aaaagaaaaa atggagtttg tacttgtaga acatatggat
    22381 gaagtattag aacaagcttt attaaagagt ggtgaaaata atgaaaatta gaagttcaga
    22441 gataactatg agtgctgtga ataaatcaca gtatccagca gaaggaatcc cagagatagc
    22501 attggctggt aggtcaaatg ttggaaaatc atcaataata aatacattgc ttaacagaag
    22561 aaactttgct agaaccagtc aaacaccagg aaaaactaga actataaatt tttatctaat
    22621 aaataatgaa ttttattttg tagaccttcc aggctatgga tatgcaaaga tagctaagtc
    22681 tgaaaaagaa aagtggggag gtataatgga acgatatcta gaaagtagac aagagttatg
    22741 ttctatattc ctacttgtag atattagaca tgagcctaca gcagatgata agcttatgta
    22801 tgaatggata aagcactttg gatataactg tgtagttatt gcaactaagg cagataaaat
    22861 atctagagga caatatcaaa aacacataag tataataaga aaaaaattgc aaatggaaag
    22921 tagtgaaaaa gtaattcctg tttcttcact aaaaaagact ggtgttgaag aattatggga
    22981 agagattgta aatcaataca atcaacatgg atatgaaata acagtagatt aaatttaaaa
    23041 tgttaaatat tgacataaga tttatttgaa taataaatgt aataatagtt agttttaatt
    23101 atattaatat taaagcaaaa tataggatgc cttaaaatag ttttaatgaa ctttttttgg
    23161 catccttatt gtttataaac aataaatatc agtaattttg ctaaatacta ataaatttta
    23221 gtaaggtatg ggaaaattag tataaattag ttcaactaaa aaattattga cttatgtagt
    23281 cagcaataaa tagcatttaa gaaatagatt tatctgtttt tctcataaag aaaacagtta
    23341 gtataagccc tataaaacat actgatgctg caatccaata agactgattg ctagctataa
    23401 cataggctga tgtgtgactt ttaaactttt gattgtatgt aagactttgt gcaaaaaaac
    23461 tactaaaaaa tgctgttcca agagcaaatg ataaattacg aatagttgca agaaaactgc
    23521 ctccgtatcc ctgtttttga ggaggaacat ctgctaaaat actactattg tttggtgaac
    23581 taaatgctcc tagcccaagt ccaaaaataa ctaaacatac aattaaaaga tacaatggag
    23641 aatctgcttt taaaagtgcc attccaacta gtgagatggt cataaatgaa aaagatgctg
    23701 ttagaatgtt ttttgcaccg tgtttatcag aaagtgaacc tgcaataggt gctataagta
    23761 ccataataag tggatgtaca gtcattacat aaccagccat cataggagat aaatttttta
    23821 attgttctaa ataaaatgga agtagaaaag atactgccat ttgaggaaaa taacaagcta
    23881 ctccaatgat attgcctaca gtaaagtttc tatttttaaa tagaggtagg tcaataaagc
    23941 tttgttcaaa ttttacttct cttaatgcca acaataagaa gattataagt gctgttatac
    24001 ctaaatacaa tcttgtatta cccttctcat tcattgcaag taatataagc gtagtgcaag
    24061 atgcgaaaag tagaagacct ggaatatcaa agctcttgtt ttgttcatcc aaaacaggtt
    24121 taggcagaaa tttaatgcca agaaagactg ctataatacc aatagggata ttgataataa
    24181 aaatagaagg ccatccaaaa tgttctaaaa ttatacctcc aattacagga ccactcatat
    24241 ttcctatacc aactacagct ccagtgattc ctatagcttt tcctttttca tttgctggaa
    24301 atgcattgga aactatacca agcccagtag ccattaaaat acttgctcca actgcctgaa
    24361 agattcttga agaaattaat gttgataaat tgtttgacat actacacaga aaagaaccta
    24421 ttgtaaatat aaaaaatcct aatgtgtata gacgatttga acctacttta tcgccaagtt
    24481 ttccgaaaaa taacatagta gctgttacaa caagcatata agctgttaca acccactgaa
    24541 tttgtgacat gttaatttta aagtcagcag caattgtagg atttgcgata tttagtatac
    24601 ttccatcaag agtagacata aatacaccaa tacagatgat aatcaatact atccattttt
    24661 gtttcatgat aacactccaa tcttaataga ttttataagt acgatataat tgtaaaataa
    24721 acaacaaaaa aagcacctgt atattaggta ccttgaatgt gtctaatttc atgaataaat
    24781 acggtagttg aaggatttgt atagattact catgtaaaat tacataaagg tactcatata
    24841 ctattttctt ctaccatcca gattttactg ttggctttgg aatatgacca aattatgcca
    24901 taaggctcgc gggcttttac cgccgatagg gaatttcacc cgtttatgaa gaaaaacaga
    24961 tgtattttgt aatattattt taacataaaa ttataatgga aacaattgga tttaagtaat
    25021 atccagctgt attacaatac aaatatttca atatggacac ttaaattgta tttatagata
    25081 gaataaggca cagtatgaga atctataata attagataaa attaacctgt tattagtatt
    25141 agatggcaag ttttaaattt gtcaaaataa gaaagctgta ataaaattct tataatatga
    25201 atatcttaat taagagatat tgtaaattat gaggaggcgc taatatggaa ggaaaggtaa
    25261 agaaggcatt cccgggtgga aatacatcac aaggctcata ttcttttttt gactatataa
    25321 ttcctgaaaa tgtaaaaaga gttttttgtt taaagggtgg acctggagta ggaaaatcct
    25381 cacttatgaa aaaaatttat aaagagtttt tgcatagagg atatgatatt gatttatatc
    25441 attgtccttc tgacccaagt tcgttggatg gtttagttat aaagaaatta ggcgtggtac
    25501 ttatggatgc aactgcccca catactatgg acccaaagct acctggagct ttggatgaga
    25561 taattaattt aggtgattac tggaatacag aagaattaga aaagaataaa caagaaatat
    25621 cagtttatga taaagatatt agtaattcat ttaaaagagc atttaagttt ttaaaatcag
    25681 cagaaccaat ctttagagac atagaagaaa aatattctga ttgtatggat tatggcaaag
    25741 taaatttggt cacagaagaa tttataaaaa ggttatttga tggagttaaa agcacaggaa
    25801 atctaaaaag agaaaagcat ttatttggtt cagctataac tcctgtaggg tgtttagatt
    25861 atacagaaaa cattttaaaa gatgtaaaga aagtctatta tttagatgga gaaataggaa
    25921 ctgggaaaac tacattatta aacaaagtat ataagaaagc tattgaaaaa ggtttaaatg
    25981 tagaagttta tcattatcca cttattccag agaaaattga aactgtacta ttaactgatt
    26041 tagacatagg tataactata agtacgactt ttaaagaaga agatacaatt gatttaaatc
    26101 agtttttaaa tagagaaaaa ctacttaaat atgaagaaga tattaaattt gatgaaaaag
    26161 ttttagatga tttaatttgt tgggcagtac taaatcttaa gagagccaag tctaaacatg
    26221 atattataga aagttactat agtcctaata tgagatttga tgaagtaggg aaattaagag
    26281 ataaattaat taaaagaatt ttaaaatatg aggaaaactt ataaacgtat atgtttaaaa
    26341 ttaatgttaa taatgatata atttttagta aattggtgta gctttgaggc tatgccattt
    26401 tacttttttt tgctaaaaaa tgatattaat aatctccaaa gcaattattt gtttttcata
    26461 attattattt cctttcctaa tttatatttt tttataatat caaaacaatg tttattgaaa
    26521 gtttatataa ttttaagaac atctaaaaat gcatacttga tattggtaaa ttagtgatag
    26581 gagttcaatg tatgatatta tatactaaag atgaatttta atatataact ttgatataat
    26641 aagcatatgt aaatgtttaa tatttaatta aagaaaatta tcatataaaa ataaatttgt
    26701 aaggagcaat acagtatgaa aaaacaatat gtgtttataa tactaacaag tactatttta
    26761 ggtatacttg ttggaaccat atttagagat tatagcaatg aagaaacagt ttatacaagc
    26821 aaagacaagt caataagaaa agaaataaaa atgacaagaa aatctataaa agaattaacc
    26881 aaagagaaag acaagttaga taaagaaatt aattcaatga aacaaaatca aaaaaattct
    26941 gaagaaatat cagaaataga aacacttaga gatagtctat catattcaga tgtaaagggt
    27001 agtgggataa tattaagtat agatgctata gatgaaaaaa cagggaatat agctaatagt
    27061 atagactata ataagattct tgtaaaagtt ataaatgaat taaaagtaaa cggaggaaaa
    27121 tacatagaaa taaatggtca aagaattaat caatattcag aagttgtact tgcaggaagc
    27181 catataaata taaatggagt tcctgtagca caaccatatg aaataaagtg cattggagat
    27241 aaggagaaac tatctaatta tgtagataaa ggtagtaaat atttagatag catacaaacc
    27301 aattatccaa tgaaaataag cataaaaact gaagaaaata tctctatgaa aaaaatgaat
    27361 atacctaata aattaaagta tataaagggt gattaagatt atattagagg aaagcagttt
    27421 gccaatgtta ataccagaaa aacttgcaaa aaaatataat gtatttccag ttgagtttca
    27481 agatgataat ttagttgtag aaatagaaga tgaggatatt tatgctctac aggacttgag
    27541 attagctaca ggtaaagaaa ttatattgaa gaaggagaaa aaagaactta taagtgaaaa
    27601 gattgaaaaa tattataata gctttgaact tgatgaggat tatgcaaaaa aattatttga
    27661 aaatctttta gaaaaagcta taaaagaaaa cgcaagtgat atacatatag aaccatttaa
    27721 agaacattta atagtgagaa tgagggtaga tggagaacta aaggaagtat caaagttttt
    27781 agttgatgtc tatccatcat tgtctacggt tataaaatta aaggcatcaa tggatataac
    27841 agaaaaaagg cttcctcagg atggtagggt ggatataaag ttaggtggaa atttaattga
    27901 cattagagtt tcatcaatac caactgtcta tggtgaaaaa atagttttga ggatacttaa
    27961 tagagatact tttttaaaag acaaattaga acttggtttt tcagaggaag ctataaaatc
    28021 tataaatcgt ataataaata aaagagcagg aatattatta gtgacaggtc ctacaggtag
    28081 tggaaagact acaacagtat attccttatt aaatgattta aaaggaataa ataaaaatat
    28141 tatgactata gaaaatcctg tagagtataa gatggatggc ataagtcaga ttcaagtaaa
    28201 ttcaaaagta gggttgagct ttgatgtagg tcttagagcg atattaagac aagacccaga
    28261 tataataatg gtcggagaaa taagagatgc agaaacagct aagatagcag taagagcagc
    28321 tataacaggt catttagtta taagtacttt acatactaat gatgcagtat cttccatagc
    28381 tagattacta gaaatgcaaa taccaccata tcttttaaat gcctctctta taggtgttat
    28441 atctcaaaag ttggttagaa aagtctgcaa tcattgtagc catgagatta tgataaaaga
    28501 taattttagt ggagatgtaa atactaaggt agctgtaggg tgtgaaaaat gtaatgataa
    28561 aggatacttt ggaagaacag caatttatga aatcttagaa attaatgatg atataaagac
    28621 atgtataaga aatatggagg attctagtac tattaaagat gtggcacaaa ataatggaat
    28681 gataacattt gaagatagtt gtaaaagact aataaatgaa aaaataacga cattagaaga
    28741 gtgtttagta gtaaatgaaa tgatttaact gaattgtata gttaaacttc gtttggtcag
    28801 ttgtctttat ttaatctatt ttaattaaga tgtttgagta taaattatat ttaagtgaaa
    28861 taaaattaaa tgcattaaat tagaaaatat taagtttatt taattgtaat taatataatt
    28921 tggaaggtat tatagtacat gagattatct aaaaatatat tttataattt agaaaagttt
    28981 tatttagtat taaatagaat cagtgataaa gaaattagag taatttgcaa agagataggc
    29041 atattgctgg aatctggatg tgaaattaca aaaatatttg agatcattga gagtcagtca
    29101 agtaaaaaag caaagaattt gcttagtata gtatcaaatc atattcaaaa aggtaactca
    29161 atagcagaat catttcaaat aacaggtata ttttctaaat tctttataag tatgataaaa
    29221 gcaggagaaa ctagtggaaa cttagatata ataatgagtg atttatctaa ttattatgat
    29281 aaagaataca aattaaaaat gaaaataata actatttcaa tatatccaat aatacttata
    29341 atattatcta tcttatcaat gttgtttata ttcgtatttg taatacctaa ttttcaggtg
    29401 gtttttacca acaatggaat tgaaccacct ttaataacta gagttttaat gggaatatct
    29461 acagtggtta caaataactt agcttatata atatttagtt ttatattgtt ttcaatagga
    29521 agcatttatt tctttataac aaatgataat ataaaaaaat tgattaattc gttaaaattc
    29581 aaaatacctt ttataaaaaa aattaatcag ttagtagcta caacaagatt ttcaagggca
    29641 ttgtccgttt taattagcag tggaatacaa attgtggaag ctatagacat gtcagctagt
    29701 gttatagaca acgaatttat ttatgaaagg ttaaagattt ccaataatta tataaaaaaa
    29761 ggaaatagca taggtaaatc tttgaattta gcaaatgttt ttccaaaatt atttatttca
    29821 atggcaaata taggagaaga aagtgggaaa ctagataaaa gtctaaatgt aataaataaa
    29881 ttttatgaaa atgaattaaa taacaaaata gagcaaataa tgaaatttat agaacctatg
    29941 ctaattgtat ttatgggatt aattattggt acttttattt tagcaatggt tgttcctatg
    30001 tttgatgcaa ttactaattt ttagagagaa aaataaattt tattagatga aacttttgaa
    30061 aaggagagaa tatttaattg ataaatttga taaataaaaa acgaaaagga tttacacttg
    30121 ttgaaatgat tgtagtagta actattttag gcgttatatc tagtatagca ttagttaagt
    30181 atagtaaggt tcaagaaagt gccaaattaa atgcagacta tacgaatgct gctaatatag
    30241 taaccgcagc tagcatggca attaatgatg atgaaaagac aatagactct ctaagtgtag
    30301 agacattgaa ggaaaaggga tacctaaata ctgttccagt tcctcagagt acatcaggta
    30361 aattcgaact tgtcataaat gatagcggaa cagatataag cgtaaatata aattctaagc
    30421 aattttatcc aaaataatat tttatattga ttgctgtaag ttttaaaatt atttttattt
    30481 aagaaggaga tggctataat taaaaaaatt ctaaacttag aaataaatga tgattatata
    30541 aggcttgtat ttttaagaaa aggtcataaa aaagttttta tagataaatc aattataaaa
    30601 gagattaact ttgatataaa aaatgatagt aattcgattg agaagattaa gtatatagaa
    30661 gatgtagtta gatttgtaaa agaggagatt ggtaaatcaa aaatattata taaaaattta
    30721 tactttaaca ttcaaattca ggatatagtc attagaaatg ttgaagttct aaatactaag
    30781 aaaaaaagag acatattaag catgattgaa tttgaaataa cacaatacat tccaataaac
    30841 ataaataact attcaataaa atataaagtt ataaattcta aaaatgataa attgaatata
    30901 caagtaattc ttttcccaaa gagtattatt caattaatta agaacatttc agaaaatcta
    30961 aatatgaatc caaagactat aaatataaat tttgatatat tacaaaagct tataaactta
    31021 aatttaatag agaatttttc agaagaaggg gtatttatag aatgtaaaaa aagtcagtta
    31081 attataaata taacaaaaga taaaaaaata agagaaacat acttgctatc aaaagaggga
    31141 aaatcatatg agttcataaa aagattatta agggatttta agtatgttta ttactatggt
    31201 atagaaaatt gttttattga agaatacttt aaatatacag ataaatctat tgaagtaaat
    31261 ccattaagat taaaagataa agtaaaagta gaaaataatt ttgatgcaga tttagaagac
    31321 aataggataa attatataag taatatagga atgattattt aagtgaaagt ggataaaaca
    31381 ataaattttc ttaatggatt taaaaaaact aaaccatgta ataaaatcta taaaataata
    31441 atagtcttaa ttttaacgtg tattttattt aaatcattta tgtatgtgaa atctataaat
    31501 gaacttgaag attatataag tcaaaataag ctagtggata aatcaaagaa tactttacca
    31561 acaacagata aaactagaga gaaattttct aaaataaaac ttaatgaaat aaaaaaaata
    31621 tatgaaacaa ttggaataaa tagtattact aaaatatcga tagataaaaa taagctagag
    31681 atggaaggtg tgtgtagtga tttagatgtt ttaaacaacc taaggaaaat aaagtacata
    31741 aaatattatt acatagacag tattgtaaga gatggagaat attatagatt tagaataaaa
    31801 agttagatgg gtgattattt ttgagattaa ataatagaga aaaaaatcta cttaaaatat
    31861 tgttaatatt agttattata ttggcaagtg atatagcagt aagttatttg gaagaaaacc
    31921 taactagttt gaaaaatgaa aagcaaaata taataaataa aataaataat caagataatt
    31981 atcaaataaa ggataataaa catatagatg ataaatatat agaaagtgtt gaatcaaata
    32041 aaaatgaaga attgaaaaat aattttaata actcattttt agataaaaaa acaaataaag
    32101 atatagtgtt attagtagaa aatgaactga gagatattgt gaatgtagaa tatattaatc
    32161 aagaaagtag tttagataat cacaataaaa aacaagttaa tttagaaata aaagttaatg
    32221 gagaacttgc aaatgtgttg aaacttgaag gtgtaatgaa gaagttaaga ctaaataata
    32281 aacttgaaaa gatagaaatt aataaattaa aagtcaataa ttttgatgtt caaaatattc
    32341 caaatgaata taaacaagaa aaagacaata ttgttgaatg taaaatgaca gttagagtca
    32401 tataacaaaa aagaatagat aaagtaaaaa actattatca attaataaaa ttttatagag
    32461 gaattagttt tacgataatt catttctaca agagggattg ttgatgattt tatcgaaatc
    32521 ctaattaaag ttaatatatt gtaccaaaat ataagtgaat ttaatagaat atttacttat
    32581 actatagatt gattaataaa aaaatggtat aataacaaat tgtactttaa tttaataata
    32641 agggagtgga agtcatattg ttagggagaa atgagctatg cccttgtgga agtggcaaaa
    32701 aatacaagaa atgttgttta aataaagata ttgtttcaga aagagcatgc agaaaaactg
    32761 aactttcaca aaaacaatat acagatttat attcaaagtt atatgattat tcaagacagg
    32821 ataagtttaa agaagaatgt gaaaaagcta aagaaatgtt ttatataatg caaaatgata
    32881 gtgtaaatga aaaatttgaa agatttttta atacttattt aatacaagac cacataatgg
    32941 aaaataaaaa ggttatgaca gttggttttc ttgaagaaaa tggtacaaac ctaagtcaat
    33001 cagaagtatc aatattaaaa agtatgtttg aatcatacgt aagtatttat gaggtaaaag
    33061 aagtttctgc tggaaaaata gtattaaagg actgtttaag tggaaatgaa ctttgtacag
    33121 aagatgtaaa acttctgaga agttttaaaa tcggaagttg tatgatagct agaatagttg
    33181 atattgaagg aactaacata ttgatagata taactataag tatatcaaat gaggttaaag
    33241 atataatttt aaaggatatt atgaatctat tcaatcaata tcaagatgta tacaaagata
    33301 tgaagtcgtt cttaatttat catacacata tactatacaa gtatatacaa cagcttttag
    33361 acccaagtat agctgaatat ttaaagagag aaagagataa aaacgataca aaagttaatt
    33421 cagaaaatga attagctgaa gaagaatgta aagttttaga tactcttaaa gaaaatgtag
    33481 aaaaagaaaa tatagatgca tgtatagagt tttggaatga atataagaaa aatcatgaaa
    33541 atataaaagg agctgaaaat ggttgggcag ctgctgttga atactatgtt aaaaaagaag
    33601 caggacaacc tataactcaa gttcaaatat caaagaaata cgatataagc tctagtacac
    33661 taggaaagag atacaaggat ttaaaaatat cttaattaat tataaaaagc tttaagtcat
    33721 agataaagaa tctatagtat aatatatgta taatgtttag aaagaggtat taataatgag
    33781 tcttagttta ggaaatgcaa ttgctgtatc aacgaacttt ataaaatcta acccagctgt
    33841 acctgtgtac aacggagaag aaatatatgc agttatttat catatagaaa taggatataa
    33901 taatggtgta tcacctgata ccaaacaata tataataata gactataaag agtttgattt
    33961 atctatggat aaaaaaaatg aactaataaa tattgctaaa gagtactgta aatctaaagg
    34021 tattgtagaa aacgaaaacc ttgaaataaa ccttttagac aatgaagaag cagagaactt
    34081 cttagaaaag gtgtttaata atatgaaggt tataagaggt cttataacta aaaaaggata
    34141 aataaatgga ctatatagga atagaaaata taacacctta tgaaaataca tatgaattta
    34201 gtgtatatga atatgatgat gaaatcacct taggtagtga aaagttatat gtatgtgaat
    34261 tgagggttgt attgattaaa gttaattctc tgtatgttga aagattgcat aaatcagttg
    34321 aagcaatggt cttagtaaaa aacttgaaaa aagatttaga taaaacactt gttgtaaaca
    34381 aaataaagaa ttttgtgcta gatgagattt gggtagaaaa tctagtaaaa gagaatatag
    34441 aagttatatt tgtagaaagc taggaataac cctagctttt ttatattaca atctaagaga
    34501 ggaaaacaat atgttaagag tatctaatgt aaaacttgga attgataaag atatatcttt
    34561 attaaaagat gttatactta agaagctaaa aataaaagaa aaaaacttag tcaaatatag
    34621 tatatataaa gaatctatag atgctagaaa aaaaggaaaa atggaatttg tttattctgt
    34681 agatgtagaa gttaaagatg aaaataaaat acttaactca aaaataaaag atgtaacaaa
    34741 aataaaggaa atcagatacg taaatgtacc tgtgggtgat aaaaaattaa agaataatcc
    34801 tttggtaatt ggtagtggac cagctggttt gtttgcaggt ctgcttttag ctcaaatggg
    34861 ttatgaacca atcatacttg aaagaggtct tgatgtagac agtagaacca aagatataag
    34921 tgatttttgg acaactagaa aattaaaaaa taattcaaac gttcaatttg gagaaggtgg
    34981 agcaggaact ttttcggatg gtaaacttac aactagaata aaagatatac gatgtagaaa
    35041 agtattagaa gagttagttc agtttggagc accagatgaa atattatact cacataagcc
    35101 acatgttgga acagatatat taaaaaatgt agttaaaaat ataagaaatg aaataataag
    35161 tttaggtggt caagttagat ttaattcaaa agtaacagat atagttgtat caaatgattc
    35221 tatacaatct gtaataataa atgatactga aaaaatagat acagatacaa ttatattagc
    35281 tgttggacat agtgcaagag atacttatga aatgttgtat tcaagaggta taaaaatagt
    35341 tcaaaaacct tttgcaatag gagctagagt tgaacatcca caagatttaa taaataaagc
    35401 acagtacaag gatttttata atcatcctag gttaggagct gcagattata gacttataga
    35461 gcatgtttca aatggaagaa cagcatatac tttttgtatg tgtccaggag gtagtgtcat
    35521 agcatctgca tcaaatgatt ttgaaatagt tacaaatggt atgagtgaac atgcaagaga
    35581 taaaataaat gcaaatagtg catttttagt aaatgtaacg ccagaagatt ttaagagtga
    35641 taattcacta gcaggtgttc atttccagca gaagtatgaa aaattagctt ttgaattagg
    35701 tggaaaaaat tataatgcac cagttcagct tgttggagat tttataaaca ataagacttc
    35761 tttgaattta ggaagtgttg agccatcata tagaccagga tatacactta caaatttaag
    35821 tgaatgtttg cctagcttcg taacagagac tatgagagaa gcgtttatat ctcttgataa
    35881 aaaattgaat gggtttgcaa tgtatgatgc tgttttgacg ggagtagaaa ctaggtcatc
    35941 atcaccaata agaatagtaa gagatgaaaa tactttagaa tcagtgagta ttaagaatct
    36001 atatccatgt ggtgaaggtg ctggatatgc aggtggtata gttacagcag cagttgatgg
    36061 tataaaatgt gcagaaaaaa taatacaaaa atacaccaat aatacaaaaa tttaacataa
    36121 acttaatgat tttttaatat ttaacatgaa tttaacatta tcactcctat aatttgataa
    36181 aatacaatag gttataaaat ttttagatac agtaatctct ttacaaggag gaaataattt
    36241 gaacattata ataagtctaa tgggtggatt aggtctgttc ttatatggta tgaaccttat
    36301 gggagaaggt cttcaaaaat ctgctgggac aaagctaaaa aagataataa aactacttac
    36361 tagtaaccta tttatgggag ttttggtagg tacaggagtt acagcagtaa tacaaagttc
    36421 aagtgctact actgtaatgg ttgttggttt cgtaaatgca ggaataatga ctttaaaaca
    36481 ggcaatagga gttataatgg gtgctaatat agggactact gttacagccc aattggtatc
    36541 tttcgactta actggtatgg ccccagtagc attaggtgta ggtattatac tttatttatt
    36601 tggaaataag cctagaataa aaaatatagc cgaaatactt ataggttttg gtatattatt
    36661 tacaggtatg gattttatga agatggcagt ggagccacta agagactatc aaggatttac
    36721 tgacttactt gttacatttg gtagatatcc actacttgga ttattattgg gatttgggat
    36781 tacagcaata atacaaagtt caagtgcatc tatgggtatg ttggttgcac tggcagcaga
    36841 aggtctagtg ccattatcag cagcactgcc aattctttat ggccaaaata ttggtacatg
    36901 tgtaacttca ctgttatcaa gtattggtgc taacaaaaat gcacgaagag cagctatgat
    36961 gcatctaatc ttcaatgttt taggaacagt gatattctta atattcttga ataaaccagt
    37021 agtaagcatg gttacaagtt gggacccaag caatgttgca agacaaatag ccaatacaca
    37081 tacattgttt aatataatat ctgtattgat acttttacca tttacaaatc ttattataaa
    37141 actagctata aagcttgttc ctgatagagc aggtgatata gatgaagatg aaactaaaac
    37201 tattaaatat atagatgata gaatgataga aactccttct atagctcttg caaatacgat
    37261 aaaagaagca cttcgtatgg gtgagaaggc gaaggaaagc ctaaatgcat ctatggaagc
    37321 tttagtagaa cattcaactg aaaaaataga taagacatat aggcgagaga gattaatcaa
    37381 tgatttacag aaagctattt taaattattt acttaaactt tcaaaagcac ctttagatga
    37441 tgattcaaga gaagttgtgg atactttgtt taatacagtc aatgatatag aaagaattgg
    37501 tgaccacgct aaaaatatag ctgaattatc gcaagttgca atagattcaa atatttcttt
    37561 ctcagaagaa ggacaatctg aacttgatgt tatgtataat agagttgttt cagcatatac
    37621 ttatgcatta gaatcaatga gaactgataa tgttgattta gcttgtaagg ttataaaaat
    37681 tgaagaacaa gttgatataa tggagaaatc ttgtagagct aatcacatgt atagattgaa
    37741 caataatcta tgtagtatag aaaatggagt tatttattta gacgtaataa gtaatttaga
    37801 gagaatatct gaccatgctg tcaatatagc acaacaagtt atagcaaaga gattaggaaa
    37861 tgattaaaaa taattaattt aaaataatat aaaatttaaa atagaggata aataaaagag
    37921 aaactttaaa tgatacgttt agagtttctt tttttgtaaa tttatttgac taaaattttt
    37981 aaatttatac atagttatag catttagaag aatcgatttc ctgataataa atgatgagat
    38041 atgtatgatt ttgtggcaaa cttttaaaaa aaacacctat attttgtgtt ataatctctt
    38101 taaaacgaat atgctgaaaa gagggattta aatgggaaaa ataaattttg attatagtaa
    38161 agctacagag tttttttgtc aaaacgaaat agatgtcatg caaccatatg tagatgttgc
    38221 gcacgacatg ttacataata aaactggttt aggaaatact tttttaggat ggatagacct
    38281 tcctaaaaat tatgataaag aagagtttga cagaataaaa aaatctgctg agaagataaa
    38341 atcagactca gatgttcttt tggtaatagg tataggaggc tcttatttag gttcgagagc
    38401 tgctatagat atggtaagtc attcttttag gaatggactt aaaaaagagc aaagaaaggc
    38461 tccagaagta tattttgtag ggcataatat aagctcaaca tatattatgg atttattaga
    38521 tataattgaa ggaaaggata tttctgtaaa tgtaatatct aaatcaggaa ctactacaga
    38581 accagctctg gcttttagaa tatttaaaga ttacttagag aaaaagtatg gtaaggaaga
    38641 agcaagaaag agaatttatg caacaacaga tgcaagtaaa ggtgcactta gacagttagc
    38701 tacagaagaa ggatatgaga cttttgtaat accagatgat gtaggtggtc gtttttctgt
    38761 attgacagca gttgggttac ttcctattgc tgctgctgga cttgatattg atgctatgat
    38821 gaaaggcgca aatgatgcta gagaagcatt tcaaaatcct gacttaaaaa gtaatgatag
    38881 ttatagatat gctgttgcta gaacaatttt acatagaaaa ggaaaagatg tagagttatt
    38941 agtgaactat gaacctcaac tacattatgt aagtgagtgg tggaaacagc tttatggaga
    39001 aagtgaagga aaagaaaata aaggtttatt ccctgcttct gtagatttct caacagattt
    39061 acattctatg ggtcaataca tacaagatgg aaaaaggctt ttatttgaga cagtacttaa
    39121 tgttgaaaac tgtaagagaa atataactat aagttcagag gaagtagact tagatggttt
    39181 aaactattta gcaggtaaga ctgtagattt tgtaaatcat aaagcttttg aaggaactct
    39241 attggctcat acagatggaa aagtacctaa tttagtaata aatatacctc aactagatga
    39301 gtataatttt ggatatttag tttatttctt tgagaaggct tgtggaataa gtggatattt
    39361 attgggagtt aatccatttg accaaccagg agtagaagct tacaagaaaa atatgtttgc
    39421 tttactaggc aaaccaggtt atgaaaaaga aaaggaagag ctagaaaaaa gacttaaata
    39481 attttaaata gttaaggttt aattaagatt aaaataatat aatgaaatca tcaaaaagga
    39541 gtttactcaa aatagatgat ttcatttttt ttatgaaaaa ttgggaaaaa tatattttga
    39601 taatttatat tatattaaga tagggagtgg tatgagatgt caagaagaaa gaaagggata
    39661 agtttagtaa tattagttgc tataataagt tcaatactta gtagttttct aacaataatt
    39721 ttagttaagg acaatttagt aagcaaatct acaggaagtt ctacgccgat agttgtaaat
    39781 gatgatggta agagtcaaaa tatttatcaa gcagttgcag aaaaagctac gccatctgtt
    39841 gtaggtatta caacaactag tgttgatact agtaatatgt ttgcaatacc aactgaaaca
    39901 caaggtgtag gaactggaat catagttgat tcaaatggat atatacttac taattctcat
    39961 gttatatcag atggtcaagc tacgagtgta aatgtattat tcaatgatgg ttcaacaact
    40021 tcaggtaaag tagtatggtt tgaccaacaa cttgatttag ctatagttaa ggttgataaa
    40081 actggactaa caccagcaga atttgctgat agtgacaaag taaaagttgg agatatatca
    40141 atagcaatag gtaatcctct tggattagat tttcaaaaaa cagttactca agggataata
    40201 agtggattag atagaactat acaaacagaa aaaactaata tgactggttt attacaaact
    40261 gatgcaagta taaatgcagg aaatagtgga ggaccattgt taaatcaaaa aggtcaagta
    40321 attggtataa acacagcaaa agcttctcaa gcagaaggat taggatttgc aataccaatc
    40381 aatacagcta agagtatagt tgaagaagta atcaaaaatg gaaaatatga aaaagtaact
    40441 ttaggcataa aaggtacaga tgtatcaaat tatgaagcag caacaggtac aaaattaagt
    40501 actgataaag gtgtttatgt tgcagaagta atatctggtt catcagcaga aaaagctgga
    40561 gtaaaggtag gggatattat aactaaagta ggagatacag atataacagg tatgaatgat
    40621 ttaaataaaa agttgtatac tttctcaaaa ggtgctagta caaaaataac agtaaataga
    40681 ggcggaaaag cagtaacaat aaatgtgaat ttctaaatat gaccagaaag atagagacta
    40741 catggtaaag tgtagtctct atttttattt aatttttata gtatatacat ctaaattaa
//
LOCUS       DAEQCW010000026        40054 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.026, whole genome shotgun sequence.
ACCESSION   DAEQCW010000026 DAEQCW010000000
VERSION     DAEQCW010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 40054)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40054)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40054
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.026"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(64..1437)
                     /locus_tag="KRO40_001363"
     CDS             complement(64..1437)
                     /locus_tag="KRO40_001363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092185.1"
                     /translation="MVLTGAHYIYILFMVIILITMIMKKDTIVPCILGVFFMGLFFEK
                     NIFGAITAVFNSFIISLNELGPIILIIAIMVALSKALEANNAIQYMVRPFSRVIKNSN
                     TAFFVTGFVMLVLSWFFWPTPAVALVGAVFLPVAMRAGLPAIGVAVALNLFGHGLALS
                     TDFVIQGAPSITAGAAGVAVSYVINDGMILFWVMGIVTISMAFYTLKRDINKGMFREE
                     LKGFESEEVEEFNGKSKIATILVALGFLADIIAMYIFDLKGGDASALLGGTAVFLIII
                     INVINFGKDSLENVCENIIDGFVFGIKIFGAIIPIAAFFYMGEVAPLTGVFGKVLAPG
                     SQGLLSDIGIALSQTIPLNKFAVSGIETVVGAITGLDGSGFSGISLVGSLASVFGTAI
                     NASVGALAALGQISGIWVGGGCLVPWGLISAAAICGVSPIELAKRNFVPVITGLVVTT
                     IVAMFII"
     gene            complement(1624..2946)
                     /locus_tag="KRO40_001364"
     CDS             complement(1624..2946)
                     /locus_tag="KRO40_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092186.1"
                     /translation="MINKIKPSKLGVILLIYVVISAAVAFILNIPFYSAVESIVKDVS
                     EGKVYFKREVNQLMDNFQTYVNNNGIRADDGDDIAKWNSDNWFVSMKIYKGNKVFYDT
                     LYYPNEVPDKSEENEFYSSPMARNYEIQFSDIKANIVVVALFRFRFQNFIEAISITFM
                     ALTFIITFLLLFSRKIKYLRKIEMGIKIVESGSLKYRIPVKGNDELSSLASSINEMSH
                     TLENQLIKEREMKNKNKDIVTSISHDVRTPLTSVICYLDLIKDHKYNSPEQLEQYIKN
                     VRSKAYQIKDLTDDLFTHFVNSGEEVSKGYEKINANEFIFQLLLDSSYTLEEKGFHIT
                     IENELYNQYHIYVDVTQFRRIFDNLCSNIIKYARKDKPIVFLIKVEDSKLLIIQKNRV
                     SNFSKNVESFGIGIKNCEKIVAYHNGSINVNSDDKEFAIEISIPAKES"
     gene            complement(2939..3643)
                     /locus_tag="KRO40_001365"
     CDS             complement(2939..3643)
                     /locus_tag="KRO40_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092187.1"
                     /translation="MNKEIPKKILVADDNPEIREIVEILLTGEGYEVIMATNGEEAVN
                     LVDSTIDLIILDVVMPVKTGFVACNEIREKTTAPILFLTAKTQDSDKVIGFSAGGDDY
                     LSKPFSYSELISRVKSLLRRYYIYQGKEKEREPNILKTKELCVNLDTQDVTLNGEPVF
                     LTTIEYSILILMLKNRKKVFSSENLYETIWDEQYFYTANNTIMVHIRNLRKKLEKDQK
                     NPQYIKTAWGKGYYID"
     gene            complement(3826..4890)
                     /locus_tag="KRO40_001366"
     CDS             complement(3826..4890)
                     /locus_tag="KRO40_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH2092188.1"
                     /translation="MISKTEKKNKCLGSVAFLVLLMGITGYFVFRGQSVESLIKSLKG
                     ASPMFILIGFVMMFIYVACEGINIYLGMKALNQKTTLLKCMGYAFIGFYFSSITPSAS
                     GGQPAQVYYMKKDDINISYSSLILLVIVVIHQVVILAYSGIMFIMEREFILNNVSGMN
                     ILLIYGVITNVALVIGVIAIIFSKKLVNNFIISITNLLGKLRIIKDVESSRKVIISQI
                     EEYVKGAQYIKQNPKLVVQILVITIVQITAMFLVPFFVYKAFHLSTYTVFEILAIQSL
                     LNIAVSSLPLPGAVGASENSFMTLFKIFFPGHLLVPAMLLSRGISFYAFVAISGLICI
                     VVHVKSSEKVKAVKKVAYVR"
     gene            complement(4893..5591)
                     /locus_tag="KRO40_001367"
     CDS             complement(4893..5591)
                     /locus_tag="KRO40_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2092189.1"
                     /translation="MYVVGLIIVVALIFLVHSIIPTYYNKLLNKKVLKNMAGENEIAL
                     TFDDGPDKRYTEKLLDVLKENDIQAMFFVVAKNAEKEPEIIKRMLRENHIVGLHSLEH
                     RNAWLYSYSYVKKDFIESTNIMKNLGVDVNYYRPPWGHTNIFSNSFVKKYNLKMTLWD
                     VMAEDWEKDSTVDIIINKLMSRTKENSIICLHDAGENSGGAVGAPERTIEALKIAIPK
                     LKASGLKFVTPERM"
     gene            complement(5582..6679)
                     /locus_tag="KRO40_001368"
     CDS             complement(5582..6679)
                     /locus_tag="KRO40_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-diphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBH2092190.1"
                     /translation="MKVLILTGKFGMGHYSASNSLSEDIKAKFDNSEIIIKDIFEYIM
                     PNYSDKMYKTFSILVNRGSSLYNLFYKCAENGKKDIKFTFSDYFLNKLDTLLHEVQPT
                     VVISTFPFCSQLVSRYKEKYNSNLPLITCITDISSHSEWISKNTDCYLVASKSTKEEL
                     VFKGIDESKIKVNGIPVKKEFKRIEHVNHSTKKNILIMGGGLGLLPKSEQFYKELNSL
                     EGVKTTVITGNNKKMYYKLYGRYENIEVVGYTNEVYKYMKDSDLIISKPGGITLFETI
                     YSELPILAFNPFLQQEIDNASFILNNEIGRILGKNKKYYVDEIKDLIYDDATLKEMSS
                     NMKELKKQFDNNTLENILFSLDEQGACRECM"
     gene            complement(7002..8246)
                     /locus_tag="KRO40_001369"
     CDS             complement(7002..8246)
                     /locus_tag="KRO40_001369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBH2092191.1"
                     /translation="MFENLKKADPEIYESMKRELKRQQRNIELIASENIVSVPVMETM
                     GSHLTNKYAEGYSGKRYYGGCEYIDEVETLAIDRIKKIFGAEHANVQPHSGANANIGV
                     YFAMLKPGDVVMGMNLSQGGHLTHGAPVNISGQYYKFYEYGIDKDSGLIDFDEVRKIA
                     HEVKPKMIVAGASAYPREIDFKKFREIADEVGALLMVDMAHIAGLVAAGLHQNPCEVA
                     DFVTTTTHKTLRGPRGGVILCKEKYAKDIDKAIFPGIQGGPLEHIIASKAVCFKEALS
                     DEFKEYQVQVAKNAKALAEELIKRDFKLISGGTDNHLILLDLTNKNITGKAAEKRLDD
                     AYITANKNTIPFDPNGALVTSGIRLGTPAVTTRGMKEEDMAIIAEAIDLCLTYDEESK
                     ARTLVVGLTEKYPLYEEYNIMD"
     gene            8574..9362
                     /locus_tag="KRO40_001370"
     CDS             8574..9362
                     /locus_tag="KRO40_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH2092192.1"
                     /translation="MNQNEELEYKKNILKLALFVGELMIKNGAETSRVEDSVLRICRS
                     RGFYHVNIFTTPTVIIISDEKFDGFSFMKTIQSRGINLNKISLLNSFSREFVSDKEYD
                     IDNAIARLYEIQDVKPYPLWLFYSCTGIASACFACLLGGNYVLNFILTFIIAIFAAIT
                     YDKTMKISAISAFSCLVSSFLIALSGVLLVEIGILDDPKMLIVGAIMPLLPGVAFIKA
                     IRDLISGNLISGISRAFDAAMIIIAIASGVGFVLDTWYRIGGPF"
     gene            9362..9835
                     /locus_tag="KRO40_001371"
     CDS             9362..9835
                     /locus_tag="KRO40_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH2092193.1"
                     /translation="MTDMSMILHFLFSGVATAGFAVFFNAPLYLLLPAGVTGGIGWIV
                     YVYLFNFTTNAVFAGFIAAALVSACSETLARKLKQPAIVFVIPGILPLIPGIGLYNTM
                     LSLIQKNYSLAMSKGTDALFLSAAIALGVLVVTSFVRTLNLLKIRKNFIPYRKSK"
     gene            complement(9927..10367)
                     /locus_tag="KRO40_001372"
     CDS             complement(9927..10367)
                     /locus_tag="KRO40_001372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SoxR reducing system RseC family protein"
                     /protein_id="HBH2092194.1"
                     /translation="MNQQGFIMEIVDDRTAKLKMQRHSACAACGKCATTNSAESKEIL
                     VEVDNTIGAKVGDHVEVSMDNMNVLKAAVMAYIIPLIALLVGTIGTYYILGAIGMTTG
                     VEAISGLVGICLTIICYLYLKKNDKKFRDSREFIPVITRILIDL"
     gene            complement(10382..10675)
                     /locus_tag="KRO40_001373"
     CDS             complement(10382..10675)
                     /locus_tag="KRO40_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="HBH2092195.1"
                     /translation="MEERKLAPNNEREALIKRLKRIEGQVKGIQKMVEQERYCVDILV
                     QISAIRSAINRVGTIILENHIKGCVAESIKHDDADKTEEMIKELMDTINKFTK"
     gene            complement(10718..11119)
                     /locus_tag="KRO40_001374"
     CDS             complement(10718..11119)
                     /locus_tag="KRO40_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092196.1"
                     /translation="MKKCLYCNRDIKSPNNKLAIKYDDNMNIYPCRAECKEKIEEYIA
                     KKPTYKFINILEVLLGVGGIFCFLSKWTIAAQVVLGIDALVIFLFPLAGFKMNGKLSM
                     EQTKNQSRSIAISILAFIVIITVLYFKQVGK"
     gene            11352..13472
                     /locus_tag="KRO40_001375"
     CDS             11352..13472
                     /locus_tag="KRO40_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092197.1"
                     /translation="MKQMELAIVSLKKDAGEIYENQIRQFLGDNLKINLYSFEEGNLK
                     FFKEKLILLSAYLKYDEIVKLSHYDAQIIVPKLTFEKNSIDMISKLEKDKIIYVYNLS
                     KDMAIETISLIHRLGIDNINILPCYPEIEFTPTDAVILTPGEKILPKFKNCEVIDLKY
                     RIIDLSCIVEIATKTKLKHLIKDDLIKKYVEKIIPTSYSTGELLLDANKFERQFDLLL
                     SIIDDGIICTNNDGIIQFYNHMARKILSINANEMIDSFVGDCIKDINFQSILTNKTPF
                     FEKLIKINHIDINLEIKHIQLNVFDGFILKMTKFSQLEKKQAKLRAQLVNSGNISKYT
                     FDDILGSSIQTINTKKIANKMAQSNSSILIIGESGTGKELFAQSIHSASRRKDGPFVA
                     VNCSTFQENLLQSELFGYDEGAFTGAKKGGKIGLFELANNGTIFLDEIGEMDLNSQSK
                     LLRVIQEKQVRRIGSNNVIDIDVRIIAATNRNLKELVSKNMFRRDLYFRLNVLPLKIH
                     PLRERPADIFEIFGSLKYDIPCNFILSEEVKEIFKMYRWEGNVRELRNLGEYFCYLEK
                     DIIEICDLPEYILDTIDSNYSRTVCNKVSDNIKKYQFNIGKDKNIMKYDYNFKRSLDE
                     YIFILDNLKKAYDLKERIGRKSLCKIALEENRFLTEQQIRNMLLELQDFGLVDILVGR
                     GGSIITSKGVEFLKNINRSNKLNS"
     gene            13697..14863
                     /locus_tag="KRO40_001376"
     CDS             13697..14863
                     /locus_tag="KRO40_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2092198.1"
                     /translation="MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAA
                     PCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLYRRHNWKIKSEWLIYSPGVIPAISL
                     LINELTKANDKIMIQEPVYSPFNSVVKNNNRELIINPLQKLENGNYIMDYEDIENKIK
                     DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMAS
                     ISKEFEKNTITCMAPTKTFNIAGLQSSYVILPDEKDYKLLDDAFTRIDIKRNNCFSLV
                     ATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPEGTYLLWVDFSALGL
                     SDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN"
     gene            14888..16330
                     /gene="nhaC"
                     /locus_tag="KRO40_001377"
     CDS             14888..16330
                     /gene="nhaC"
                     /locus_tag="KRO40_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBH2092199.1"
                     /translation="MKMNTERKIPSFRYSLLVMLAIIALTSVGIVVFNASITTMFLLS
                     WLIVVPAAMKLGYTNDEIEAFGFEVGKDAFQSNLIILSVGVLIAAWIAAGTIPTVVYS
                     GLTIITPKYFLLTTLIVCSLTSVATGTSWGTLGTSGIAMMSIGTSMGIPLGLTAGAVI
                     SGAFFGDKMSPLSDSTNLAAAVCKTDVITHMKHMFYTTGPAYVICIVLYTVIGFKYSN
                     NTIDYVQINQIKDVLNSNFHIGLVAMIPIIFLLLLLLLQKPPIISILSSAIMGLIIAV
                     FQEGEKIGDVLNYMLSGFTIDTGFVYADKLLNRGGIMSMAETVLLVFVVFVIAGILQK
                     TGFLEVLLQPLITKIGKSRTKLVGSTFIVSYFANAFSSSMMFTSVFVGTLMSPIYKEF
                     KLKPQNLSRIIEDTATLGGPLIPWNSNAVFCAQTLGVSPLEFIPYCFLSWITPIISFI
                     YGVTGFTMLTYTDDEIEELEIFDTAQRRVD"
     gene            16333..16602
                     /locus_tag="KRO40_001378"
     CDS             16333..16602
                     /locus_tag="KRO40_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092200.1"
                     /translation="MKFEYYYLIQDIAGILLAFIGLRMSIIGFRILSMKGLSINTLLI
                     VIKYCLFTIAGLNLLISKFGIRHWIWSVCMLIISIIINPRIKVSK"
     gene            complement(16679..18106)
                     /locus_tag="KRO40_001379"
     CDS             complement(16679..18106)
                     /locus_tag="KRO40_001379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp14"
                     /protein_id="HBH2092201.1"
                     /translation="MKLTKSISSMLCLSLVLSLSPVAYANEISRTTVENTLVGQDRYQ
                     TAVEVSKKGWSSANEAVVVNSESIVDALAVTPFAKLKNAPILLTEKNNLNSQTEKELK
                     RLGVKKVYIIGLSSSVSNDVQKQLESNNLTTDRVGGSDRYQTALSIAKKIEGLKDISE
                     IAVVNGYTGLADAVSIASVAATNGMVILPVSDASGISSFKDFIESKNINKSYIIGSTN
                     AVSDKIKQSLPNSERIGGADRNETNGKVIEKFYTSNKLNNVFVAKDGMKNQNQLIDAL
                     AVGVLASKENSPVLIVGEQLSATQKSVFSNKNATSITQVGSGGNENAFKELKDLQANS
                     NNKRVMYVTNTDKVNIRNDATIEASVIGYLNNGDEVEVLDVLKTGWVKIKYNEGIGYV
                     SGSYLTNNKPDNSNENIKIKYVKEKDGLNVRKGPSTEDEKMGQLSYGSKVETVEMFAT
                     GWVKIKYNGGYGYVSNDYLSDTPVI"
     gene            18478..19347
                     /locus_tag="KRO40_001380"
     CDS             18478..19347
                     /locus_tag="KRO40_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2092202.1"
                     /translation="MDLLHLKYFQTVARMEHITKASHKLNIAQPALSKTISSLEKELG
                     VQLFDRKGRYIVLNEYGRLFLKRVDSILDLVESSKKELQDTSLENSGEVKILSPAAAN
                     VLPSLLSNFRKLYPNITFNVSHTLPSSYKKSDFDLYISSSFTKLNSENSITLTCEEIL
                     LGVSINHPLSLKDEVYLSEVSDENFIVITKGENYREVIDILCESANFKPKIAFESDSP
                     YTIYALIKSLQGVGFICGKSWGLSQDPEIKLLHIKDIEFKRYLNLSWFSENYESKAVL
                     LFKNFLINYFKNI"
     gene            complement(19459..20265)
                     /locus_tag="KRO40_001381"
     CDS             complement(19459..20265)
                     /locus_tag="KRO40_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase"
                     /protein_id="HBH2092203.1"
                     /translation="MGRKVKIGIIQQHSVLGNVKKNIEKAVEMIDDLGKQGADIICLP
                     ELFATGYNLESLGGVKTLELIREHNKYIEESMSEAAKRNNVYLISPYGTLEKGSTHVY
                     NSAVIFDRKGKIMGEYCKNHLWSLEAVYFKGGEKVEVYDADFGRFGVMICYDAGFPEV
                     SRELTLKGSEIIFIPSAWRIQDEDMWDLNVSQRALENTVYTVGVNLVSNDSNLILFGK
                     SKICNPRGTVITQLDTYREKYVLSEIDLDEIKKYREDIPYLKDRKSSYNI"
     gene            complement(20279..21511)
                     /locus_tag="KRO40_001382"
     CDS             complement(20279..21511)
                     /locus_tag="KRO40_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBH2092204.1"
                     /translation="MQEREELVLNPVPKEERVGWLAPLFNMLGSNIAISELMVGGTLI
                     LGMTLSNMIITSIIGNLILVAIIMIQGYIGYKEGLNTYVLAKGAFGEIGGKYLISLLL
                     GITSFGWFGVQAGVAGLSVQKIFPSVNLTLVTVILGLFMVVFALYGFKAMAKFNYLVI
                     PPLMILMVWGVFKAFSTYGVEAIYNYTPQTTMSMVEGLNIVVGLVIVGAIISPDQLRY
                     TRRVKDIWIISFLGLGIISLFQQVAAGVMSMGAPTWDITEVLANLGFGWVAFVILILA
                     SWSTNVSNAYSGGLALKTIFPNVKRNVLTLVAGLIGTIIAATGIIFKFQSFLSFLGIA
                     VPAIAGIMWCEYYFIQGRTYKHREGINWIAVISWLIGFAASYYSSKINFLIPPINGIV
                     VSMVIYYILMNCFGIKDK"
     gene            complement(21970..23757)
                     /gene="aspS"
                     /locus_tag="KRO40_001383"
     CDS             complement(21970..23757)
                     /gene="aspS"
                     /locus_tag="KRO40_001383"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HBH2092205.1"
                     /translation="METLKGLKRTHYCGELREKNINEEVVLMGWVQKKRNLGGLVFVD
                     LRDTSGLCQIVFDTDVDKEAFEKAEKLGAEFVIAVKGKVCERQSKNPNMPTGDIEIFA
                     TELRLLNKSETPPIYIKDDDDVSEALRLKYRYLDLRKPSMQRNLKLRHKVMNITRNYL
                     SNNRFCEIETPFLIAPTPEGARDYLVPSRVNPGKFYALPQSPQLYKQLLMVSGMDRYF
                     QIVKCFRDEDLRADRQPEFTQIDCEMSFVEQEDVMSMIEGLLEAIFKEVLDVELALPL
                     PKMTYAEAMSKYGSDKPDTRFGYELTDISDVVCNCGFKVFADATQPGKSVRGINVKGK
                     ADDFTRKQISSLEEHAKTYRAKGLAWMKVGQEGVTSPIAKFFNEEEMNAILTRMNAEV
                     GDLLLFVADKNSIVFDALGQVRLEVANRLNLLDKNVYNLLWVTEFPVFEEDEETGTFS
                     AMHHPFTSPMDEDLDKLEEGDKSSLRAKAYDIVLNGYEIGGGSVRISNSDVQSRMFKA
                     LGFTEERANEKFGYLLEAFKYGTPPHAGLAFGLDRLVMLLAGTDNIREVIAFPKNQNA
                     VCPMTNAPTLAEDEQLEELSIKVDIKDNE"
     gene            complement(23831..25093)
                     /locus_tag="KRO40_001384"
     CDS             complement(23831..25093)
                     /locus_tag="KRO40_001384"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HBH2092206.1"
                     /translation="MLTKAPRGTKDITPKEAYKWRYVENKFREICALYGYEEMVTPIF
                     EHTELFKRSVGDTTDIVQKEMYSFKDKGDREITLKPEGTAGVVRAFIENKLYADTQPT
                     KLFYVTPCFRYERPQAGRQRQFHQFGIEALGSDTPSMDAEIIALAVQFFNEVGLNDLV
                     VSINSVGCPVCRKEYNALLKEYLDSKADILCDTCNERREKNPMRVIDCKNPTCKENIK
                     DIPFIADHLCDDCKSHFDKLQEYLKEMNINFVIDKTIVRGLDYYRKTAFEIISNDIGA
                     QSTVCGGGRYDGLVEQLGGPKGISGIGFGLGIERLLLTLEGNGIEIENPQSTDIFIVT
                     IGEKANTRSFKLLKDLRQNHISADKDHIERSVKAQFKYSDKINSKFTIVIGDDELKND
                     TATLKNMKTSEQTTVKLSTLVEELKQKL"
     gene            complement(25083..26639)
                     /locus_tag="KRO40_001385"
     CDS             complement(25083..26639)
                     /locus_tag="KRO40_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="HBH2092207.1"
                     /translation="MLYVFLKGHDYKYEVAELIKLFTSEFKFKDSNANNNIESKHLIN
                     RLIYENGVLFSSTEYYENGNLKYESIQNIENMNLEFLDGFDSSKTIEEFLNSLDSESK
                     RNFKKLCKENIKKSMFVVLKQVFNSYVPWGILTGIRPVKIVHNLMDKKLDDNSIRTIL
                     KDNYFIIDEKIDLALEIAKRERLFMYPIDKNKISLYVSIPFCPTRCVYCSFPSNSLKQ
                     FGHLKREYVYKLIEEIKGFAKVIKETKKEVETLYIGGGTPTTLDEEELDLLINSLFNE
                     LDLSKIKEFTVEAGRPDTITEQKLRVLKKHNVSRISINPQTMNDDTLVKIGREHRVSD
                     LVDCFNMARRMGFDNINMDIILGLIDEDLNMVKNTLEEIKKLSPESLTVHTLAIKRAS
                     NLNINMDRYKEHLTQYEEMVKMIDLSMKYAKDMGLNPYYMYRQKHMLGNLENIGYAKE
                     GYECIYNIQIMEEKQSNYALGAGAISKFVYVDEDRIERVENVKNVEQYIERVDEMIKR
                     KKEEVYKNVD"
     gene            complement(26730..27344)
                     /locus_tag="KRO40_001386"
     CDS             complement(26730..27344)
                     /locus_tag="KRO40_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2092208.1"
                     /translation="MIIKKFVDSYFGVNTYVLGDEKTKKCAVIDPGGSLVETLSFVKE
                     NELNIEYIILTHGHGDHIGYVKDIKEKTGAKVVAHVDEKELLNDKNKNLSYTMRCGAQ
                     EFDADIYVNDKDKLELGELKMTFLHTPGHTQGCMCIRVEDEMFTGDTLFAGSIGRTDL
                     YSGDFNQMEKSLKKLCKYEDAVRVYPGHGPTSTLGVEKKTNPYM"
     gene            complement(27359..27808)
                     /locus_tag="KRO40_001387"
     CDS             complement(27359..27808)
                     /locus_tag="KRO40_001387"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HBH2092209.1"
                     /translation="MRAVVQRVSSSKVTVDENTIGQINKGLLVLLGVTHDDKSSDVDY
                     MIDKILNLRIFEDENDKMNLSLMDIGGELLVVSQFTLYGDCRKGRRPGFSNAARPELA
                     NNLYEEFVKKAKDKGVTVGTGQFAAHMMVELTNDGPVTILLDSSKSF"
     gene            complement(27833..30040)
                     /locus_tag="KRO40_001388"
     CDS             complement(27833..30040)
                     /locus_tag="KRO40_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003229747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HBH2092210.1"
                     /translation="MHDKELQEIIEKIKVYAPNANFEMVEKAYNLAKKAHEGQYRKSG
                     EPYFIHPLAVANILIEMELDIETITAGLLHDVVEDTEYTYEDIKKEFGKEVADLVDGV
                     TKLGQIKYRSKEETQSENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYMPPEKAKYK
                     AKETLEIYGGIAHRLGISKIKWELEDRALRFMDPEGYYDLVSRVSMKRSQREDYIQGI
                     VELLKDKFKDLSIPCDVYGRPKHFYSIYRKMQKKHKTFEEIFDLTAVRILVDNVKDCY
                     AVLGIVHTLWRPIPGRFKDYIAMPKPNMYQSLHTTVVGPDGEPLEIQIRTHEMHNIAE
                     NGIAAHWKYKEGISSKESKVEEKLQWLRQMMEWEKDLKDPQEFMDALKEDVFNSQVYV
                     FTPKGDVIELPAESTPIDFAYRVHTNVGNKCVGAKIDGRIVPIDYKLQNGNIVEVLTS
                     SNSNGPSRDWLNIVKTPNAKSRIRQFFKKERREENVDRGNTILEREFKKHDIPQKDPL
                     VEKYMALVAKKFNQPSVEDLIATVGYGGIMSSQVVSKVKDLYLKEVKKAKKEQQIQEE
                     DLNKHNISETEYSKKRKKNASQGIIVKGLDNILVRFAKCCNPLPGDEIVGYITKGRGV
                     AIHRADCPNANNNGDFFQNRLVEVSWSSAGKGKFEAEIQIKAIDRRGIVNEITHIVAM
                     DKLSLNGINARKGKDSIVSINLLVEVNDTEELKILMKKLKAIPGVESIYRMTN"
     gene            complement(30114..30626)
                     /locus_tag="KRO40_001389"
     CDS             complement(30114..30626)
                     /locus_tag="KRO40_001389"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HBH2092211.1"
                     /translation="MDLKNFIRNIDDFPKPGIDFKDVTTLFKDGDAFKYAVDSIVEEL
                     KDKDVDLVIGPEARGFLMGTPVAYALGVGFVPIRKPGKLPGEVESYEYGLEYGTDTLE
                     IHKDAIKKGQKVAIVDDLLATGGTMEAAAKLVEKLGGEVVSMQFLIELKFLNGREKLS
                     NYDVNSLIKY"
     gene            complement(30639..33089)
                     /gene="recJ"
                     /locus_tag="KRO40_001390"
     CDS             complement(30639..33089)
                     /gene="recJ"
                     /locus_tag="KRO40_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HBH2092212.1"
                     /translation="MKKWILKYKGKIEESEFSKKLNISPEICQILKNRGICTEKDSEI
                     FMNPSLDYLRDPFLMKDMQKAVDRIKLAVEKNEKIWIYGDYDVDGVSSTSILCLYFKS
                     IGYNVDYYIPNRLEEGYGINEDAIKLISSRGCDLIISVDCGITSVSEVNTANDLGIDV
                     IITDHHECQSEIPSAFAVINPKQEDCNYPFDSLCGCGVAFKMIQALTPKEEFKTSMYN
                     YLEIVTLATICDIVPLIDENRIIVKNGLKSMKEGKNIGLRELIKVCGVESDKIGSSHI
                     GFAIGPRINASGRLGYSYLGVELFTTQSQEEAVEIASILEEKNNERQMIEAKMYHEAE
                     EMLKSNSRYNDDKVLVLAKEGWQHGIIGIVASKLTEKYYKPTILLGIENGEATGSARS
                     IKGFNIFEALIKCKDLMTKFGGHEQAAGLSLDSDNVEILANEINKFADYNLTEDDMIE
                     NVNVEFELQENVINLNLVEELHKLEPFGLNNPNPRFIVRNYILKDLKVIGKNQQHLKL
                     SIEKEKSYECIGFNMSHLKSMYKVGDKVDVLFQLDENNYMGNRKVQFLLKDIRLARPK
                     SASNDKLSLKLMSKIIPKDTQSLYNISVSDFELFDGNTDINIFDYFEKDTLIISNSIN
                     GFYRAMSDISLIDLDFNINYNIIEDVSKNTDKLELIFSPNIDKIDLKRYNNIILYDYL
                     YNKGEYSYIYENKREESEIIKYYNKTDLLYLKNVVSNIVPSRDEFITIYKQALIKKEI
                     DLDMVNIRETFNVIPLKFFTILNVFRELNLLDFNLNYEKNSVLIRILPKPQKKLDLNE
                     SLILNNLKNLEKQYNSSY"
     gene            complement(33102..34766)
                     /locus_tag="KRO40_001391"
     CDS             complement(33102..34766)
                     /locus_tag="KRO40_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="HBH2092213.1"
                     /translation="MRISYRNLKRYREIGYVLIKYGFSFIVERLNIEGIAYKIPLFDP
                     PEEIKNMTTGERMKRVLEELGPTYIKIGQILSTRKDLLDQDIIDEISKLRDDVEKFDS
                     NIAIDIFKEEVGLSIEEIFLEFKEEPIAAASIGQVYEGVLKTGEEVIVKIQRPNIEKI
                     IKSDLEILRTIANTLKDLKKDFNLDLVQMIEEFQTQLMRELDYTFEAINATKFSRIFK
                     NSDEVYIPKVYSEYNTKKILVMEKVNGTKLSDVEKIRRLGYNTKTIVEIGVRSFFTQV
                     LSHGFFHADPHPGNIFVIAKNKIAYIDFGMIGIIDNKTLNQLNEIALAGVEKNVDKII
                     YLLIEMDALNGEADIKGLRQDLLYLIHYYYDISIEKINVTDILNELFRFFRQYKIVMP
                     AQFVTLAKTVITLEGTSRTLNTDFSFGSMGKEFMKHHYKSKFNPKNVVLSSRQNVEEI
                     LLDIKTIPKQLKAILKNIERNNIKMQIEDVKMTRLENCIIELTSQISLSLVLASIIVG
                     SSLIIASPNIENNIWIKFTAIAGFFISFIIGLCLVIRSIRSKYKKD"
     gene            complement(35064..35561)
                     /locus_tag="KRO40_001392"
     CDS             complement(35064..35561)
                     /locus_tag="KRO40_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma carbonic anhydrase family protein"
                     /protein_id="HBH2092214.1"
                     /translation="MIRDYLEDKPLIDESVFVAKSADVIGNVKIGKDSSIWYNAVVRG
                     DEGPITIGENTNIQDCSIVHGDTETIIGNNVTVGHRSIVHGCKISDNVLIGMGSIILD
                     NAEIGEYTLIGAGTLITSNKKFPPGVLIMGSPGKVVRELTEEDKKYIDESYEWYLEAA
                     QNQKY"
     gene            complement(35590..36969)
                     /gene="scfB"
                     /locus_tag="KRO40_001393"
     CDS             complement(35590..36969)
                     /gene="scfB"
                     /locus_tag="KRO40_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="HBH2092215.1"
                     /translation="MSMIHKFSMNGYNIVLDVNGGAVHVLDDVAYDLLDFYKEKSKEE
                     ILEILKSKYQEEKINEAYEEILNLEKEGLLYTEDTYQYHPSFVHREPVVKALCLNVAH
                     DCNLKCKYCFAAQGDFGGEKELMSFEVGKAAIDYLIANSGSRKNLEIDFFGGEPLMNF
                     EVVKQLVDYGRSVEKDYNKNIRFTITTNGVLLNDEIIDYINENMHNVVLSLDGRKEVN
                     DNMRPTLNDKGSYDITLPRFKKLVEKRAKDKYYYIRGTFTRDNLDFSKDVMHFADLGF
                     KLTSVEPVVGDESNPYALREEDLPKIFEEYEKFAVEYADRQLQGDGFKFFHFMIDLNQ
                     GPCVIKRITGCGAGNEYLSVTPNGDIYPCHQFVGNEEFKMANIFDEEIVLPENLKNMF
                     REAHVYTKEECKQCWNKFYCSGGCHANAINFNNDISKPYELGCEMQRKRTECSIMIQA
                     KLMLEGATN"
     gene            complement(37274..37420)
                     /locus_tag="KRO40_001394"
     CDS             complement(37274..37420)
                     /locus_tag="KRO40_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="HBH2092216.1"
                     /translation="MKKFIVRFMKFASSLALSTAILSANSTCPWIIHQPKVPKEISNL
                     KKTN"
     gene            complement(37450..38028)
                     /locus_tag="KRO40_001395"
     CDS             complement(37450..38028)
                     /locus_tag="KRO40_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory gene regulator B family protein"
                     /protein_id="HBH2092217.1"
                     /translation="MFKRYAEKMTSVLICNNMIDNNESKVYSYGFEILIAFIVNITTM
                     LFIGFLFGKFTYVLFFLMCYCPIRQFSGGYHADNYFRCLLTFIFIILSTILIIENINI
                     DLFKNIIMIIASVSWVGICVLCPIEHRSNPISDREKLVYKKTAIFISTVVLLITILSL
                     SLSIFVDYFTYSAFAMFWIFVMLVLGKLKAKV"
     gene            complement(38396..39826)
                     /locus_tag="KRO40_001396"
     CDS             complement(38396..39826)
                     /locus_tag="KRO40_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH2092218.1"
                     /translation="MDIKNKIKSIFLPEKNDYLDDEEFEYDIENNEEDLKEDNKVHLN
                     DLSRVKYDYRELKDIENQTEEICLLAVKQDGTIIEFVKDKTYKVCMEAVKQTYKSLKY
                     ITNQNEDICIEAVKQNYRALYYINNKTENVLIEAIKNASTYDVMEVFKFVEEQTEDVC
                     LAFIERASKNDVAEILKGIKEQTPAICLEAVKKDGKSLAYVKEQSNSICLEAVKENYS
                     ALSCVKEQTEEICIEAVKQNDFALYYVNEQTEKICMEAVKRSYMALQYVNKQTEEICL
                     EAVRIDGRALQYVKEQTEEICLESVRQNGKVLQYVKKQTENICIEAVRGSFEELEIKE
                     ILSYVKIPTERIFVEAVKQNGKILKYVENQTELICLEAVRENYNALAYVKEQTEKICL
                     EAVNQSYEALKYVKEQTEEVCLKAVKQDYRMLKYVNNQTEKICLEAVKQNYRALEFVD
                     NQTEKVCLEAVKQNRKALQYVKQKQS"
BASE COUNT        13144 a         6892 c         4503 g        15515 t
ORIGIN      
        1 ttataataaa ttatagctac acatctattt ttaatttata caattaaaga tttattcgat
       61 ttattaaata ataaacattg ctactatggt tgttacaacc aatccggtta taactgggac
      121 aaagtttcgc tttgccaatt ctattgggct aactccacaa attgccgctg ctgaaataag
      181 accccaagga actagacagc ctccacctac ccatatacca ctgatttgtc ctaatgcagc
      241 tagtgcacca acacttgcat ttatagcagt tccaaataca gaggcaagtg aaccaactaa
      301 tgaaatccca gaaaatccag aaccatcaag cccagttatt gctcccacta cagtttctat
      361 acctgatacg gcaaatttat taagtggtat tgtttgagaa agagctatgc ctatatctga
      421 taataaacct tgtgaacctg gtgctaatac ttttccaaat acacctgtca atggtgcaac
      481 ttcacccata tagaaaaatg ctgctattgg tataattgct ccaaatattt ttatcccaaa
      541 cacaaaacca tcaattatat tctcacatac attttcaaga ctatctttgc caaaatttat
      601 aacatttata attattatta aaaatactgc tgttccaccc aaaagagctg atgcatctcc
      661 tccttttagg tcaaatatat acatagcaat tatatcagca agaaatccca gagctactaa
      721 aatagttgct attttagatt ttccattaaa ctcttctact tcttcacttt caaaaccttt
      781 tagttcttct ctaaacattc ctttgttaat atctcttttt aatgtataaa atgccataga
      841 tatggttacg attcccatca cccaaaacaa aatcatacca tcatttataa catatgatac
      901 tgcaacacct gctgcaccag ctgttatact tggagctcct tgaataacaa agtctgtaga
      961 taaggcaaga ccatgaccaa ataaatttaa tgctactgca acaccaattg ctggtagccc
     1021 agctctcata gcaacaggta aaaatacagc tccaactaag gcaacagctg gagttggcca
     1081 gaaaaaccaa gaaagaacta acataacaaa tccagttaca aaaaatgctg tattagaatt
     1141 ttttataact ctcgaaaatg gtctcaccat atactgtata gcattattgg cttctagggc
     1201 tttagataat gcaaccataa tagctataat caagataatt ggacccaact catttaaaga
     1261 tataataaaa gagttaaaca ctgctgttat agcaccaaaa atgttttttt caaagaacaa
     1321 ccccataaaa aaaacaccta atatacatgg tactattgta tcctttttca taatcatagt
     1381 aattaatata attaccataa atagaatgta aatataatgt gctcctgtca aaaccatatt
     1441 attatgtccc ctttttttaa gataataata ttatatggtc ttataagtaa acttgttact
     1501 tgcctagagg tacacaatat tgaacatccc ataactaaag tcacatgctt cctgcttcat
     1561 agaattttac ataagcaatt acacaatata taatagcaat tacacaatat ataatttaaa
     1621 tttttatgat tcttttgctg gaatagatat ttcaatagca aattctttat catctgaatt
     1681 tacatttatg cttccattat gatatgcaac tattttctca caattcttta taccaattcc
     1741 aaaactttct acattcttag aaaaattact tactctattt ttttgtataa ttagtaattt
     1801 agaatcctct actttaatta aaaatactat aggcttatct ttcctagcat attttattat
     1861 attagaacat aaattatcaa atatccttct aaattgtgta acatctacat aaatatgata
     1921 ttggttataa agttcatttt ctattgttat atgaaatcct ttctcctcca atgtatatga
     1981 actatctaaa agtaattgaa aaataaattc attagcattt attttttcat acccttttga
     2041 aacttcctct ccagaattaa caaaatgcgt aaaaaggtca tctgttaaat cttttatttg
     2101 atatgcttta gaccttacat tttttatgta ttgttccaat tgctcaggac tattgtattt
     2161 atggtcttta atcaaatcta aataacaaat tactgacgtt aatggagttc taacatcatg
     2221 tgatatcgaa gttactatat ctttattttt attcttcatc tccctttctt ttataagttg
     2281 attctccaat gtatgactca tctcattaat actagatgca agtgatgata attcatcatt
     2341 accttttact gggattctat actttaaact gccactctct actatcttta tacccatttc
     2401 tattttcctt aggtacttta tctttctact aaacaacagt aaaaatgtta taataaatgt
     2461 aagtgccata aatgtaatag aaattgcttc tataaaattt tgaaatctaa atctaaataa
     2521 agctactaca actatattag ctttaatatc agaaaattgt atctcatagt ttctagccat
     2581 gggactgcta taaaactcat tttcctcact cttatcaggt acttcattag gatagtataa
     2641 tgtatcataa aaaaccttat ttcctttata tatcttcata gaaacaaacc aattatcact
     2701 attccatttt gctatatcat ctccatcatc tgctcttata ccattgttat tcacataagt
     2761 ttgaaaatta tccataagtt gatttacttc tcttttaaaa tatactttcc cttctgatac
     2821 atcttttact atagattcaa cagcagagta aaatggtata tttaaaatga aagccactgc
     2881 agctgagatt actacatata tcaatagtat aactcccaac ttagatggct taattttgtt
     2941 aatcaatata ataccccttt ccccatgcgg tttttatata ttgtggattt ttttggtctt
     3001 tttctaactt ttttcttaaa tttctaatat gaaccattat tgtattattt gctgtataaa
     3061 aatactgctc atcccaaata gtttcatata aattttcaga cgaaaaaact ttttttctat
     3121 ttttcaacat aagaattaat atactatatt ctatagttgt caaaaacaca ggttctccat
     3181 ttagtgtaac atcttgagta tctaaattga cacataactc ttttgttttt aatatatttg
     3241 gctctctttc cttttccttt ccctggtata tataataacg tctaagtaga gacttaaccc
     3301 ttgaaattag ttcagaatat gaaaaaggct ttgataaata gtcatctcct cctgctgaaa
     3361 atccaataac tttatcagag tcttgagttt ttgcagttaa aaataatatt ggtgctgtcg
     3421 ttttttctct aatttcatta catgcaacaa atcctgtttt tacaggcatt acaacatcca
     3481 aaataatcaa atcaatcgta ctatctacta agtttacagc ttcttctcca ttcgttgcca
     3541 taataacttc ataaccttca ccagttaaaa gtatttctac gatttcccta atctcaggat
     3601 tatcatcagc tactaaaatt ttttttggaa tctctttatt catcaccaag ctcctttttt
     3661 tgctatattt cttaaatatt tcaaactata taaaatatta tactttatta gcaaaagctt
     3721 agcaatgtca cacgttttaa tagtttctac tcctgtaaac atgtttaaag cttaattaaa
     3781 atatacacac aaattgacat attaataaaa ataatctata taatattatc ttacataagc
     3841 aacttttttc actgctttta ctttttcaga agattttaca tgtactacta tacatatcaa
     3901 tccacttata gctacaaatg cataaaaact tatcccccta ctaagtaaca ttgccggaac
     3961 taataagtga ccagggaaaa atatcttaaa taatgtcata aaactatttt cagaagctcc
     4021 aacagcccct ggcaatggta atgaagaaac agcaatatta agcaaggatt gtatcgctaa
     4081 tatctcaaat acagtatatg ttgatagatg aaaagctttg tatacaaaga aaggaactaa
     4141 aaacatagct gttatttgta caatagttat gactaaaatt tggactacaa gttttggatt
     4201 ctgctttata tattgagcac ctttaacata ctcttcaatt tgagatatta taacttttct
     4261 tgaactttca acatctttta ttattcttaa cttacctaat aaatttgtta ttgatattat
     4321 aaaattgttt acaagttttt ttgaaaatat aattgcaatt actccaatga caagagcaac
     4381 atttgttatt acaccatata ttagtaaaat gttcatacca cttacattat ttaatataaa
     4441 ctcacgttcc ataatgaaca ttattccact atatgccagt ataactactt ggtgaataac
     4501 aacaatgact aatagtataa gtgaagaata tgatatattt atatcgtctt ttttcatata
     4561 ataaacttgt gctggttgac cacctgatgc tgaaggtgta atagaactaa aataaaatcc
     4621 aataaaagca tatcccatac attttaaaag agtagtcttt tggtttaaag ctttcatacc
     4681 taagtatata tttatacctt cacaggcaac atatataaac atcattacaa atccaattag
     4741 tataaacata gggcttgcac cttttaatga ttttatcaat gattcaactg actgccctct
     4801 aaaaacaaaa tatcctgtta tgcccattag taaaactaaa aaagctacac tacctaggca
     4861 tttatttttc ttttcagttt tacttatcat aactacatcc tttctggtgt tacgaacttt
     4921 aaaccactgg ctttaagttt tggaatagct atctttaaag cttcaatagt acgctcaggt
     4981 gcacctactg caccacctga attttcacct gcatcatgta aacaaattat agaattttct
     5041 tttgttctac tcattaactt gtttataata atgtctactg tactatcttt ctcccaatct
     5101 tctgccatta catcccacaa agtcattttt agattatatt ttttaacaaa tgaatttgaa
     5161 aatatattag tatgacccca tggtggacga tagtagttta catctacacc taaatttttc
     5221 attatatttg tactttcaat aaaatctttt ttaacataac tataactata aagccatgca
     5281 tttctgtgtt ccaatgaatg taaaccaact atatgatttt ctctcaacat tctttttata
     5341 atttcaggct ctttttcagc attctttgct actacaaaaa acatagcttg tatatcattt
     5401 tcttttaaca catctagtaa tttttctgta tatctcttat ctggaccatc atcaaatgta
     5461 agtgcaattt cattttctcc agccatattt tttaatacct ttttatttaa tagtttatta
     5521 tagtatgtag gtataattga atggactaaa aaaatcaatg caacaacgat aattaaacct
     5581 actacataca ttctctacac gctccttgtt catcaagtga aaataaaata ttctctaagg
     5641 tattattatc aaattgtttt tttaattctt tcatgttact gctcatttct ttaagagtag
     5701 catcatcata aattaaatct tttatctcat ctacatagta ttttttattt ttaccaagta
     5761 ttctcccaat ttcattattt aatataaaac tagcattatc tatctcttgt tgtaaaaatg
     5821 gattaaatgc caatattgga agttctgaat aaattgtttc aaatagtgtt attccacctg
     5881 gtttagaaat aataaggtca gaatctttca tatatttata tacttcattg gtgtaaccta
     5941 ctacctctat attttcatat ctaccatata gtttatagta cattttttta ttattaccag
     6001 ttattacagt agtttttact ccttctaaac tatttaattc tttgtaaaat tgttctgatt
     6061 taggcagtaa tcctaatcct ccacccatta taagaatatt ttttttagtt gaatgattta
     6121 catgttctat tcttttaaat tcttttttta ctggaatacc attaacttta atcttagatt
     6181 catctattcc tttaaaaaca agttcttcct tagtagattt actagctact aaataacagt
     6241 ctgtattttt actaatccat tctgagtgac tacttatatc agttatacat gttattaaag
     6301 gaagatttga gttatatttt tccttatatc ttgatactaa ttgagaacaa aatggaaaag
     6361 ttgaaataac tactgttggt tgtacttcat gaagtaatgt atctaattta tttaaaaaat
     6421 aatctgaaaa agtaaatttt atatctttct ttccattttc agcacattta taaaataaat
     6481 tataaagact acttccccga tttacaagaa tagaaaaagt cttgtacatt ttatctgaat
     6541 agttaggcat aatgtactca aatatatctt taattattat ttctgaatta tcaaattttg
     6601 cttttatatc ttcacttaaa gaatttgatg ctgagtaatg acccatacca aattttcctg
     6661 taagaattaa taccttcata agattccctc ctcgttaaag cttttctttt catatgatta
     6721 ctatacttat aagtatagac tttaaatctt tagaaaaacc tagtataatt cttaagaaat
     6781 cttaaagttt taattaaaaa atacaaagag accatctaaa aatagagata accatatttt
     6841 ttattattta aataatacaa atatgttcga ttccatacaa aaaagtgcct cataaactaa
     6901 aaagttcatt ttgagacacc ttttttatat ctaaatatat tcaaatacat acacaatcat
     6961 tgtaattatt taaatgtatt ttatttagtt gttctttata attaatccat aatattatat
     7021 tcttcatata aaggatattt ttcagttaaa ccaacaacca atgttctagc cttagattct
     7081 tcatcataag ttaaacatag gtctatagcc tcagcgatta ttgccatatc ttcttctttc
     7141 atacctctag tagttacagc tggagtacca agtcttattc cacttgtaac aagagcacca
     7201 tttgggtcaa atggaattgt atttttatta gctgttatat aagcatcatc caatctcttt
     7261 tctgctgctt taccagttat atttttatta gtcaaatcta atagtattaa atgattatct
     7321 gtacctccag aaatcaattt aaaatctctt ttaataagtt cttcagctaa ggcttttgca
     7381 tttttagcaa cttgtacctg atattcttta aactcatcac ttaaagcttc tttaaagcaa
     7441 actgccttag aagcaattat atgttcaaga ggtccacctt gaataccagg gaatattgct
     7501 ttgtctatgt ctttagcata tttttcttta caaagaataa cacccccacg aggtcctctt
     7561 aaagttttgt gagttgttgt tgtaacaaaa tcagccactt cacatggatt ttggtgaaga
     7621 ccagcagcca caagacctgc tatatgagcc atatctacca taagcaatgc tccaacctca
     7681 tcagctatct ctctaaactt tttaaaatct atttctctag gatatgcact tgctcctgca
     7741 actatcattt taggttttac ttcatgtgct atctttctaa cttcatcaaa atctataagt
     7801 ccactgtctt tatctatacc atattcataa aatttataat attgaccaga aatattaact
     7861 ggagcaccat gagttaaatg tccaccttga gataaattca ttcccataac aacatcacct
     7921 ggttttaaca tagcaaaata tacaccaata tttgcatttg ctccagagtg aggttgaaca
     7981 ttagcatgtt ctgctccaaa tatttttttg attctatcta ttgcaagagt ttcaacttca
     8041 tctatgtatt cacatccacc ataatatctt ttgcctgagt aaccttctgc atacttattt
     8101 gtaagatgac ttcccatagt ttccattact ggaactgata ctatgttttc agatgctatt
     8161 aattcaatat ttctttgttg tctttttaac tctcttttca tactttcata aatctcaggg
     8221 tccgcttttt tcaagttctc aaacatatta ctcctcctag ttattattta aattttattt
     8281 ttacagacat ttcataattt tcgtttttat caatatgata atttattatt atagtccttt
     8341 accaattaat agtcaagtgt tttgccattt ttccatattt aacatagtta ctttctttat
     8401 ttttaagtta aaatataata aataatattg tctaattctt ttaattggat ataatttaaa
     8461 tgtgactatt ttgaaacaaa aaaaagataa tatatttata tagatattaa ggaatattac
     8521 ttaaaaattt gatataattt caatattacg ttttttaatt tggaggtgta tttatgaatc
     8581 aaaatgagga acttgaatat aagaaaaata ttctaaaact agctctattt gtaggggaac
     8641 tgatgataaa aaatggagct gaaacatcta gggttgaaga cagtgtcctt agaatatgca
     8701 ggtcaagagg gttttatcat gtaaatattt ttacaactcc tacagtaata attatttcag
     8761 atgagaaatt tgatggcttt tcgtttatga aaacgattca atcaagaggt ataaacttaa
     8821 ataagatttc tttattaaac agtttttctc gagaatttgt tagtgacaaa gagtatgata
     8881 ttgataatgc cattgcacgt ctttatgaaa tccaagatgt aaaaccttat cctttatggt
     8941 tattttactc ttgtacagga attgcatctg cttgttttgc ttgtttgctt ggagggaatt
     9001 atgtattaaa ttttatactt acgtttataa tagcaatctt tgctgcaatt acttatgata
     9061 aaacgatgaa gataagtgca atatctgcat tttcctgttt agtatcttct tttttaattg
     9121 cactttcagg agttctacta gttgaaatag gcattttaga tgaccctaaa atgcttatag
     9181 tcggcgctat aatgccacta ctcccaggag ttgcttttat aaaagctatt agagatttaa
     9241 tatcagggaa tttaatatca ggaatttctc gtgcttttga tgctgctatg attattattg
     9301 caattgcttc tggagttggt tttgtccttg atacatggta tagaatagga ggtcctttct
     9361 aatgactgat atgtctatga ttttgcattt tttattttca ggtgttgcaa ctgctggatt
     9421 tgctgttttc tttaatgctc cactatatct acttcttcca gctggagtaa ctggcggaat
     9481 tggttggatt gtatatgttt atttatttaa ttttactaca aatgcagttt ttgcaggttt
     9541 tatcgctgct gctttggtct cagcgtgcag tgagacttta gcaagaaaac taaagcaacc
     9601 agctattgtg ttcgtaattc caggtattct tcctctaata ccaggaattg ggctatataa
     9661 tacaatgttg tctttgattc agaaaaatta ttctttggct atgtcaaaag gtacagatgc
     9721 tctatttcta agtgctgcaa tagcacttgg tgtattagtt gtaacttctt ttgtaagaac
     9781 attgaatctt ttaaaaatca gaaaaaactt tattccttac agaaaatcaa aataaaaata
     9841 taaaaatagc aatgtactta aactctacaa atacgtattg agtatttatt taaaaagtac
     9901 attgctattt tttaattata attatcttaa aggtcaatta atattcttgt tattactggt
     9961 ataaattctc tactgtctct aaattttttg tcattcttct ttaagtataa ataacagatt
    10021 attgtaagac aaattccaac taatccactt atggcttcaa ctccagttgt cattccaatt
    10081 gcccccaata tataataagt ccctattgtt cctacaagaa gtgctataag aggtattata
    10141 taagccatta cagctgcttt taatacattc atattatcca tactcacttc tacatggtca
    10201 ccaacttttg caccaattgt gttgtctact tctactaata tttcttttga ctctgctgaa
    10261 tttgtagtag cacattttcc acaagcagca caagctgaat gtctttgcat ttttaacttt
    10321 gcagttctat catcaacaat ttccataata aatccttgtt gattcataac taaccgcctc
    10381 cttattttgt aaatttattt atagtatcca taagctcttt tatcatctct tcagttttat
    10441 cagcatcatc atgtttaatg ctttctgcta cacatccttt tatatgattc tctaagataa
    10501 ttgtgcctac tctatttata gcagacctta tagcagatat ttgaaccaat atatcaacac
    10561 aataacgttc ttgttccacc atcttttgta tacccttaac ttgaccttct attcttttta
    10621 atctttttat gagagcttcc ctctcattgt ttggtgctaa ttttctttct tccataaact
    10681 cacctcatac tctaatgatg tcttatacaa ttatgctcta cttaccaact tgtttaaaat
    10741 ataatacagt tattattact ataaatgcca aaattgatat tgcaatagac ctactttgat
    10801 tcttagtttg ttccatactt aactttccat tcatcttaaa tcctgccaat gggaataaaa
    10861 atataaccag tgcatcaatt ccaagtacaa cttgggctgc aatagtccat ttactcaaaa
    10921 agcagaatat tccgcccaca cctaaaagaa cctctaatat atttataaac ttatatgtag
    10981 gtttttttgc tatatattct tcaatttttt ccttacattc tgcacgacat ggatatatat
    11041 tcatattgtc atcatatttt atagctaatt tattatttgg tgactttata tccctattac
    11101 agtaaagaca ttttttcatt ttatattctc ctctagtctt ccttaaaaaa ttttgcctaa
    11161 attattatac gctctaatac tattatacca aatagataca aaaaacaaaa ataaaaggaa
    11221 taattttagc tacttctttt acttcaatgt gtagtctata ataaatttat aataataatt
    11281 aaataatatt atttaatcta atttaattat tatgtaatct aaaataagtc aaatttgtat
    11341 gagaggttaa aatgaaacaa atggaattag ctattgtaag tttaaaaaaa gacgctggag
    11401 aaatttatga aaatcaaata agacaattct taggtgataa tctaaagata aatttatact
    11461 catttgaaga gggaaattta aagtttttta aagaaaaact tatactccta tctgcttatt
    11521 taaaatatga tgaaatagta aaattatctc actatgatgc tcaaatcatt gttcccaagt
    11581 tgacatttga aaagaacagt attgatatga tatccaaatt agaaaaagat aaaattattt
    11641 atgtatataa cttaagtaaa gatatggcaa tagaaacaat ttctttaata catagattag
    11701 gaatagacaa tataaatatc ctgccctgct atccagagat tgagtttact cccacagatg
    11761 ctgtaatcct aactcctggc gaaaaaatct tgcctaagtt taaaaattgt gaagttatag
    11821 atttaaaata cagaataata gatttaagtt gtattgttga aattgctaca aaaaccaaat
    11881 taaaacatct aataaaagat gacctaataa aaaaatacgt agaaaaaata attcctacaa
    11941 gttatagtac aggtgagtta ttgttagatg caaataagtt tgaaagacaa tttgatttgt
    12001 tactatctat aattgatgat ggaattatat gcacaaataa cgatggaata attcaattct
    12061 ataatcatat ggctagaaaa attttgtcta taaatgcaaa tgaaatgatt gactcatttg
    12121 ttggtgattg cataaaagac atcaattttc aaagcatatt gaccaataaa actccatttt
    12181 ttgagaaatt gattaaaata aatcatattg atataaattt agagattaaa catatacaat
    12241 taaatgtatt tgatggattt atactaaaga tgacaaagtt ttctcaatta gaaaaaaagc
    12301 aagctaaatt aagagcacaa ctagtaaact ctggtaatat cagtaaatac acatttgatg
    12361 atatattagg ttctagtata caaactatta atacaaaaaa aattgctaat aaaatggctc
    12421 aatcaaattc atctatactt ataattggtg aaagtggtac tggtaaagaa ttatttgctc
    12481 aatccattca tagtgcttct aggagaaaag atggtccttt tgtcgcagta aattgtagta
    12541 cttttcaaga aaatctactg caaagtgaat tatttggcta tgatgaaggg gcttttactg
    12601 gtgctaaaaa aggtgggaaa attggtttat ttgaattagc caacaatgga actatatttt
    12661 tagacgaaat tggagaaatg gatttaaatt ctcaatctaa attacttaga gtcatacaag
    12721 aaaaacaagt acgacgtatt ggttctaata atgtcattga cattgatgta agaataattg
    12781 cagctactaa tagaaattta aaagaacttg tatctaaaaa tatgtttaga agagatttat
    12841 attttaggtt gaatgttctt ccccttaaaa tacatccact tagggaaaga cctgctgata
    12901 tatttgaaat ttttggttca ttaaaatatg atattccatg taattttatt ctaagtgagg
    12961 aagtaaaaga aatctttaaa atgtatagat gggaaggaaa tgtaagagaa ttaagaaact
    13021 taggagaata cttctgttac ttagaaaaag atattataga aatatgtgat ttacctgaat
    13081 atatattgga tactatagat tcaaattata gtagaaccgt ttgtaataaa gtaagtgata
    13141 atataaaaaa gtatcaattc aacattggca aagacaaaaa catcatgaaa tacgactata
    13201 attttaaaag gtcactagat gaatacatat ttatattgga taatttaaaa aaggcttatg
    13261 atttaaaaga aagaataggt agaaaaagct tatgtaaaat agctttagag gaaaatagat
    13321 ttttgacaga acaacagatt agaaatatgc ttttagaact acaagacttt gggcttgtag
    13381 acatacttgt tggtcgtgga ggttcaatta taacatcaaa aggagtagaa tttctaaaaa
    13441 atataaatag gtctaacaag ttaaacagtt aaacctattt aacctattta attacatttt
    13501 catatattta aaaatttatt agaaataacc ttttccacaa agttttaagt ataattaata
    13561 tttttatctt atctatgctc tgaaattact taatattaaa tattaacttg tgaataaata
    13621 ttttttatta tcaatattgg cacgttgttt gcttaatatt attaacataa aattaaaatt
    13681 actggaggta tttacaatga attataattt taatgagatt gttgatagaa gcaataattt
    13741 ttcatctaaa tggtcagaaa tggaaaaaaa gtatggaact aatgatttac ttcctatgtg
    13801 ggtggctgac atggatttta aggctgcacc ttgtataatt gattccttaa aaaatagact
    13861 agaacaagag atttatggct acacaacaag accagattct tacaatgaat ctatagtaaa
    13921 ctggctatat aggagacata actggaaaat aaaaagtgag tggttaattt atagtccagg
    13981 tgttatccca gctataagtc ttttaataaa tgaactcaca aaagcaaatg ataaaataat
    14041 gatacaagaa ccagtttaca gcccttttaa tagtgttgta aaaaataaca atagagaact
    14101 aattataaac ccattacaaa aactagaaaa tggaaactac ataatggatt atgaagacat
    14161 tgaaaacaag attaaagatg taaaattatt catactttgt aatcctcata atccagttgg
    14221 tagagtatgg acaaaagatg aattaaaaaa actaggagat atttgtctta agcataatgt
    14281 aaaaatcata tctgatgaaa tacatagtga cattatatta aaaaaacata agcatattcc
    14341 tatggcatct atttctaaag aatttgaaaa aaatacaatt acttgtatgg ctccaactaa
    14401 aacttttaat atagctggtc ttcaatcatc atatgtaata ctacctgatg aaaaagacta
    14461 taaattgtta gatgatgcct ttaccagaat tgatataaag agaaataatt gctttagctt
    14521 agttgcaact gaagcttcat ataataatgg tgaatcttgg ctagaatcat ttttagaata
    14581 tttagaatct aatatagatt ttgctataaa atatataaat gaaaatatgc caaaacttaa
    14641 agttagaaaa ccagaaggta cttatttatt atgggtagac tttagtgcac ttggattaag
    14701 tgatgaggaa ctagaaagta tacttgtaca aaaaggtaaa gttgctctaa atcaaggaaa
    14761 cagctttggc attggaggaa gtgggtatca aagaataaac ttagcttgtc caagaagtat
    14821 gcttgaagaa gctcttataa gaataaaaaa tgcaattaac taaaaatatt taaggagaat
    14881 ttgcactatg aaaatgaata cagaaagaaa aataccttca tttagatatt ccttgttagt
    14941 aatgcttgca ataatagccc taacatcagt tggtatagtt gtatttaatg cttctataac
    15001 tacaatgttt ttactttcat ggcttatagt agttcctgca gccatgaaac ttggttatac
    15061 taatgatgaa atagaagctt ttggatttga agttggtaaa gatgcctttc aatcaaactt
    15121 aattatactt tctgttggtg tactaatagc agcttggata gctgctggta caataccaac
    15181 agtagtatat agtggactaa caataataac ccctaaatat tttctgctta caacattaat
    15241 cgtatgttca ttaacttctg ttgctactgg tacatcttgg gggactcttg gaacttctgg
    15301 tatagcaatg atgagtattg gtactagtat gggcattcct cttggtttaa cagctggtgc
    15361 agtcatttct ggtgctttct ttggagataa gatgtcacct ctatcagatt ctacaaactt
    15421 agctgcagca gtttgtaaga cagatgtaat tacacatatg aagcatatgt tttataccac
    15481 aggacctgca tacgtaatat gtatagttct gtatacagta attggattta agtactcaaa
    15541 taatactata gactatgttc aaataaatca aatcaaggat gtattaaatt caaactttca
    15601 tattggttta gtagcaatga ttccaataat atttttatta ttacttttat tgctacaaaa
    15661 gccacccatt atatctatac taagttcagc tatcatggga cttattatag cagtatttca
    15721 agaaggagaa aaaataggtg atgttttaaa ttacatgcta tcaggattta ctatagatac
    15781 tggatttgtc tatgccgaca aactattaaa tcgtggtgga ataatgagta tggctgaaac
    15841 cgttttacta gtatttgtag ttttcgttat tgctggtatt ctccaaaaaa ctggattctt
    15901 agaagtactg cttcaacctc ttataactaa aataggaaaa tcaagaacta aattggttgg
    15961 gtctactttt atagtaagct actttgcaaa tgcatttagt tcatcaatga tgttcacttc
    16021 tgtatttgtc ggaactctaa tgtctccaat atacaaagaa tttaaattaa aaccacaaaa
    16081 tctatctaga attatagaag atacagctac acttggtggt ccattaatac catggaattc
    16141 aaatgctgtt ttctgtgctc agactcttgg tgtaagccca ctagaattta ttccatattg
    16201 tttcttaagt tggattacac ctataatttc atttatttat ggtgtaactg gttttactat
    16261 gcttacatac acagatgatg aaattgaaga gttagaaata tttgatactg ctcagagaag
    16321 agttgattga atatgaaatt tgaatactat tacttaattc aggatattgc aggtatatta
    16381 ttggcattta taggacttag aatgtctatt attggattta ggatactttc tatgaagggg
    16441 ctttctataa atacactttt aattgtaatt aaatactgct tatttaccat agcaggactg
    16501 aatttattaa tatctaagtt tggaattaga cactggattt ggagtgtttg tatgttgata
    16561 atatccataa taataaatcc caggattaag gtatcaaaat agaaatagtt attagactta
    16621 aatttttata aaaaaactgc tttacaaatt aaagcagttt ttttattgtt acttataatt
    16681 aaataactgg tgtatcagat aagtaatcat tacttacata accatatcca ccattatact
    16741 ttatttttac ccatccagta gcaaacattt ctactgtttc tactttgctt ccatatgaaa
    16801 gttgacccat tttttcatct tctgtacttg gtcctttcct aacatttaga ccatcttttt
    16861 cttttacata ctttattttt atattttcat tactattatc aggcttatta tttgtcaaat
    16921 aagacccact aacatatcca ataccttcat tgtattttat ttttacccat ccagttttta
    16981 acacatctaa aacttctact tcatcaccat tatttagata tcctataaca gaagcttcta
    17041 ttgtagcatc atttcttata tttaccttat ctgtattagt tacatacatt actctcttat
    17101 tgttactatt tgcctgtaaa tcttttaatt ctttaaatgc attttcattt cctccactac
    17161 caacttgagt tatagaggta gcatttttat tcgaaaatac actcttttgt gttgcactta
    17221 attgttctcc tacgattagt acaggagaat tttcttttga tgctagtact cctactgcta
    17281 gagcgtctat aagttgattt tgatttttca ttccatcctt agccacaaat acattgttta
    17341 atttattaga tgtataaaac ttttctatta ctttaccatt agtttcattt ctatctgctc
    17401 cacctattct ttctgaatta ggtaaacttt gttttatttt atctgataca gcattagtag
    17461 agcctattat gtatgattta tttatattct tagattctat aaaatcttta aagctagata
    17521 taccagatgc atcagatact ggaagtataa ccattccatt agtagcagct acagaagcta
    17581 tactaactgc atctgcaaga cctgtgtacc catttactac agctatttct gatatatctt
    17641 ttaatccttc tattttttta gctatactca aagctgtttg gtatctatca ctaccaccaa
    17701 ctctatcagt agttaaatta ttagattcta actgtttttg cacatcattt gatacagaac
    17761 tagatagacc aattatataa acttttttaa ctcctaatct ttttaattct ttctcagttt
    17821 gtgaatttag attatttttt tctgtcaata atataggagc attttttaat ttagcaaatg
    17881 gtgttacagc taatgcatct acaatagatt cactatttac aactacagcc tcatttgcac
    17941 tactccatcc ttttttactt acttcaacag cagtttgata tctatcctga cctactaaag
    18001 tattctcaac tgttgttcta cttatttcat ttgcatatgc tactggtgat aagcttaaaa
    18061 ctagagataa gcacagcatt gatgatattg atttagttaa tttcatcttg actcccccta
    18121 aaattatagt atctaaatgt ttcctattta aaatagtata acataataat ttaagtaaca
    18181 tcattattat aaaatattat ttttcttatc taataagctt ttattcttac ttgacattaa
    18241 tactttgctc atcaaatgaa ttttttatat aactaaagtt tgtaacaata tttccttagt
    18301 taatcattta aagttacttt ttttaattag attatgtaca aaatataaat aacaatttaa
    18361 ataacttttt aatatattgt agtttattat ataaacttta tattataatg tataatgtgg
    18421 agttgattat aaaattgata taactcaagt catattaaaa gaggtgtatt ttatactatg
    18481 gatttattgc atcttaagta ttttcaaact gttgctagaa tggagcacat aacaaaagca
    18541 tcacacaagt taaatatagc acagccagct ttaagcaaaa ctatatcttc cttagaaaaa
    18601 gaacttggag ttcagttatt tgacagaaaa ggaagatata ttgttttaaa tgagtatgga
    18661 agattgtttc taaaaagagt agatagcatt ttagatttag tagaaagttc aaaaaaggag
    18721 ttacaagaca cttctttaga aaattcagga gaagtaaaga tattatctcc tgcagcggct
    18781 aatgtgttac catcactttt gagtaatttc agaaaactat atcccaatat tacttttaat
    18841 gtgtcacata ctttgccatc atcttataaa aaaagtgatt ttgatttgta catatcttct
    18901 tcatttacaa agctaaactc agaaaatagc ataactttaa catgcgaaga aatactatta
    18961 ggagtttcaa taaaccatcc tttatcatta aaggatgaag tatatctaag cgaagtttca
    19021 gatgaaaact ttatagttat aacgaagggt gagaattata gagaggtaat tgatatcctg
    19081 tgcgaatcag ctaatttcaa acccaaaata gcatttgagt ctgattcacc atatacaatt
    19141 tatgctctta taaaatcact tcaaggagtt ggatttatat gtggaaaatc atggggatta
    19201 tctcaagacc ctgagattaa gttgttacat atcaaagata ttgaatttaa aagatattta
    19261 aatctttcat ggtttagcga aaactatgaa tctaaagctg tgttgttgtt caaaaacttt
    19321 cttatcaact attttaaaaa tatttaaatc aaagttgata atattaaaga ggatatatca
    19381 aagtataata aatttaatct taatattgat acatcctctt tttatcattt tatattgaac
    19441 ttgtattata gtatagaatt atatgttata gctacttttt ctgtctttca aataggggat
    19501 atcttcccta tactttttta tttcatctaa atcaatctct gataatacat atttttccct
    19561 gtatgtatct aattgagtta ttacagtacc tctaggattg catattttac tctttccaaa
    19621 tagtattaaa ttagagtcat tacttactaa atttacacct actgtatata cagtgttctc
    19681 taaagctctt tgagatacat ttaaatccca catatcttca tcttgtattc tccatgcaga
    19741 tggtataaat attatttcag aaccttttaa tgtcaattct ctggatactt ctggaaaacc
    19801 tgcatcataa catatcatta caccaaatct accaaaatca gcatcatata cctctacttt
    19861 ttcccctcct ttaaagtata ctgcttctaa tgaccacaga tgatttttac agtattctcc
    19921 cataatctta ccttttctat caaatataac tgctgaatta taaacatgtg tagacccttt
    19981 ttctaaggtt ccatatggag atatcaggta tacattattt cttttagcag cttctgacat
    20041 tgattcctct atgtacttat tatgttctct tattaattct aatgttttaa ctccacctaa
    20101 agactctaaa ttatatcctg tagcaaatag ttctggtaaa caaattatat ctgccccttg
    20161 ttttcctaag tcatctatca tctctactgc tttttctata ttttttttaa catttccaag
    20221 tacactgtgt tgttgaatta tacctatttt caccttacga cccatgtaat tgcccccttt
    20281 atttatcttt gattccaaaa caattcatta atatataata aataaccata ctcactacaa
    20341 ttccatttat cggaggtatt aagaaattta tttttgaact ataatacgac gctgcaaaac
    20401 ctattaacca acttattact gcaatccaat ttattccttc tctatgctta taagttcttc
    20461 cttgtataaa ataatactca caccacataa ttcctgctat tgcaggaact gcgattccca
    20521 agaaagataa aaatgactga aatttaaata ttataccagt agctgctatt attgtaccta
    20581 ttagacctgc aactaaagtc aaaacatttc tttttacatt tggaaaaata gtttttaatg
    20641 ctaatccacc agaataagca tttgatacgt ttgtagacca agatgcaagt attaaaataa
    20701 caaacgctac ccatccaaaa cctaaattag ccaatacttc tgttatatcc caagtaggtg
    20761 ctcccataga cattacacca gctgcaactt gttggaataa tgaaataatc cctagaccta
    20821 aaaaactgat aatccaaatg tcttttactc gtctcgtata tcttaactgg tcaggtgata
    20881 taattgcacc aactataaca agacctacta caatattaag accttcaacc atactcatag
    20941 ttgtttgagg agtataatta taaatagctt caactccata agtagaaaaa gctttaaaaa
    21001 ctccccacac cattaatatc ataagtggtg gtataactaa gtaattaaat ttagccatag
    21061 ctttaaagcc atacagtgca aaaacaacca taaataatcc aagtataact gtaactaatg
    21121 ttaggtttac acttgggaat atcttttgta ctgatagtcc tgcaacccct gcttgtacac
    21181 caaaccatcc aaaactagtt ataccaagta atagagatat aagatacttt cctcctatct
    21241 ctccaaatgc ccccttagct aatacatacg tatttaaccc ttctttgtaa cctatataac
    21301 cttgtatcat aataattgca actaatatta agttccctat aattgatgta ataatcatat
    21361 tagaaagagt cattcctaaa attaaagttc ccccaaccat tagttcagat atagctatgt
    21421 tagaaccaag catattaaac aatggagcta accatccaac tctttcctct tttggaactg
    21481 gatttaaaac taattcttct ctctcttgca atattatccc tccctttctt tataaaagaa
    21541 taatttctac ttttttctac ttttttttca ctattaatag aatttttctt tatataattg
    21601 taattctatt ctacaaaaaa gtataatatc tagtttgtta tcaatttgat ataatttaag
    21661 ttataaatag ataaatagtc caaatttatt attttaattt aatctattaa gtcatatatt
    21721 agacttattt caaatttgtt atatattctt taattaaaat cgtgtactca ttacagaagt
    21781 agtttctaaa acaatcaagt ttatgtaaaa tttttaaaca tagtatttta attatattgg
    21841 ctgagaatac aaagataatt tatgaaaata tatagagaaa aaatataaaa taattctaat
    21901 aaaaaaagtc tgaatataaa tatactttat atccagactt tttacatttt agtttcttgc
    21961 aactacatat tattcattat cttttatatc aacttttata cttaattctt ctaattgctc
    22021 atcttctgcc aatgtaggag catttgtcat agggcaaaca gcattttgat ttttagggaa
    22081 tgcaataact tctcttatat tatcagttcc tgcaagtaac ataacaagtc tatcaagacc
    22141 aaaagctaga ccagcatgag gaggagtacc atatttaaat gcttctaata aataaccaaa
    22201 cttttcatta gctctttcct ctgtaaaacc aagtgcttta aacattcttg attgaacatc
    22261 agaatttgat attctaacac ttcctccacc tatttcataa ccattcaata caatatcata
    22321 agctttcgct cttaaagatg acttatcacc ttcttctaac ttgtctaaat cttcatccat
    22381 aggtgatgta aatgggtgat gcattgctga gaatgtgcct gtttcttcat cttcttcaaa
    22441 aactgggaac tcagttaccc atagtaagtt atatacattt ttatccaata gattaagcct
    22501 atttgctact tcaagtctaa cttgtcctaa agcatcaaat actattgagt ttttatcagc
    22561 tacaaataaa agtaaatctc ctacttcagc attcattctt gtaagtatag cgttcatttc
    22621 ttcttcatta aagaattttg ctattggaga agttactcct tcttgtccta ctttcatcca
    22681 agcaagacct tttgctctat atgtcttagc atgttcttct agtgatgata tttgttttct
    22741 agtaaagtcg tcagctttgc cttttacgtt tatacctcta acactttttc ctggttgtgt
    22801 agcatcagca aacactttaa atccacagtt acaaacaaca tcagatatat ctgttaactc
    22861 atatccaaat ctagtatctg gtttatctga accatattta gacatagctt ctgcataagt
    22921 catcttagga agtggaagtg ccaattctac atctaaaact tctttaaata tcgcttcaag
    22981 caaaccttca atcatactca taacatcttc ttgctcaaca aaagacattt cacagtctat
    23041 ttgtgtaaac tctggttgcc tatctgctct taaatcttca tctctaaagc atttaactat
    23101 ttggaaatat ctatccatac cacttaccat caataattgt ttatataatt gtggtgattg
    23161 tggtaatgcg taaaattttc ctggattaac tctacttggt actagataat ctcttgctcc
    23221 ttctggtgtt ggagctatta aaaatggtgt ttctatttcg caaaatctat tgtttgataa
    23281 gtaatttctt gtaatattca ttactttatg tcttaatttt aaatttcttt gcatagatgg
    23341 ttttcttaaa tctaagtatc tatattttaa tcttagtgct tcagaaacat catcatcatc
    23401 ttttatataa ataggcggag tttctgactt gtttaaaagt ctaagttcag ttgcaaatat
    23461 ttctatatca ccagttggca tattagggtt tttagattgt ctttcgcata cttttccttt
    23521 tacagctatt acaaattcag cccctaattt ttcagctttt tcaaaagctt ctttatctac
    23581 atctgtatca aaaactattt gacataatcc acttgtatct cttaaatcaa caaatacaag
    23641 accacctaaa tttctttttt tctgtaccca tcccataagt acgacttctt catttatgtt
    23701 tttttctctc aactctccac agtagtgagt tctctttaaa ccctttaaag tttccaagat
    23761 actacctcca ttttatttaa ttttaatgct atatatttat ctaatacaca aaacatcata
    23821 ctttcttatt ttacagcttt tgctttaatt cttcaactaa tgtacttaat tttacagtag
    23881 tttgctctga tgttttcata ttttttaatg tcgcagtgtc atttttaagc tcatcatctc
    23941 caattactat tgtaaatttt gaatttattt tatctgaata tttaaattgt gctttaacac
    24001 ttctctctat atggtcttta tctgcactta tatgattttg tctcaagtct tttaacaatt
    24061 taaagcttct tgtatttgct ttttcaccta tagttactat aaatatatcc gtagattgag
    24121 ggttttctat ttcaattcca ttaccttcaa gtgtaagtaa aagtctttca attcctagtc
    24181 caaacccaat tccacttata ccttttggtc ctcctaattg ttcaacaaga ccatcatatc
    24241 ttcctccacc acatacagta ctttgagctc ctatatcatt agatataatt tcaaaagcag
    24301 tttttctata gtaatctaag cctctaacta ttgttttatc aattacaaag tttatattca
    24361 tttcctttaa gtattcttga agtttatcaa agtgagattt acaatcatca cacaaatggt
    24421 ctgcaataaa tggtatatct ttgatatttt ctttacatgt aggattttta cagtctataa
    24481 ccctcattgg atttttttct cttctctcat tgcaagtatc acacaatata tcagcttttg
    24541 agtcaagata ctcttttaat aaagcattgt actcttttct acaaactgga cagccaactg
    24601 aatttatact cactaccaaa tcatttaatc caacttcatt aaaaaattga acagctagtg
    24661 cgattatttc agcatccatt gaaggagtat cacttccaag tgcttctatt ccaaattggt
    24721 gaaattgtct ttgtctacca gcttgtggtc tttcatatct aaaacaaggt gttacataaa
    24781 ataattttgt tggttgagta tctgcatata atttattttc tataaatgct cttactacac
    24841 ctgctgtacc ttctggcttt agggtaattt ctctatcacc tttatcttta aaagaataca
    24901 tttctttttg aactatatct gtagtatctc caacacttct cttgaaaagt tctgtatgtt
    24961 caaatatagg tgttaccatt tcttcatatc catataaagc acatatttct ctaaatttat
    25021 tttctacata acgccatttg taagcctctt ttggagttat gtctttagtt cctctaggag
    25081 ctttagtcaa catttttata tacctcttct ttcttccttt ttatcatttc atctactctt
    25141 tcaatgtatt gttcaacatt ttttacattt tctactcttt caattctatc ttcatctaca
    25201 taaacaaatt tcgatatagc acctgcacct aatgcatagt tactttgttt ttcttccata
    25261 atctgtatat tataaatgca ctcatatcct tctttagcat aacctatatt ttctaaattt
    25321 cccaacatat gtttttgtct atacatataa tatggattta atcccatatc ttttgcatat
    25381 ttcattgata aatctatcat ttttaccatt tcttcatatt gtgttagatg ttctttatac
    25441 ctatccatat ttatatttaa gttggatgct ctctttatgg ctaatgtatg aactgtaagg
    25501 ctttcaggag aaagtttttt tatctcctcc aatgtattct ttaccatatt taaatcttca
    25561 tctataagac ctaaaattat atccatattt atattatcaa atcccattct acgagccata
    25621 ttaaagcaat ctactaaatc agatactcta tgctctcttc caatctttac caaggtatca
    25681 tcattcatag tttgaggatt tatactaatt ctactaacat tgtgtttttt taacactctt
    25741 agtttttgtt ctgtaatagt gtcaggtcta cctgcttcta cagtaaattc tttaatttta
    25801 cttaaatcta attcattgaa caatgaattt ataagcaaat ctaattcttc ctcatcaagt
    25861 gtagttggag ttccaccacc aatatataga gtttcaactt ctttcttagt ctccttaata
    25921 actttggcaa accccttaat ttcttcaatc aatttataaa catattctct ttttaaatgt
    25981 ccaaattgtt ttaatgaatt tgaaggaaat gaacaatata cacatctagt tggacaaaat
    26041 ggaatactta cataaagaga aattttattt ttatctatag gatacataaa taatcgctct
    26101 cttttagcta tttcaagagc taaatctatt ttctcatcta ttataaaata attatctttt
    26161 agaatggttc ttatgctatt atcatctagc tttttatcca ttaaattgtg gacaattttg
    26221 actggtctaa taccagtcaa aattccccat ggtacataag aattaaatac ttgtttaagc
    26281 actacaaaca tgcttttttt gatattttct ttacacagct ttttaaagtt cctcttactt
    26341 tcactatcta ggctattaag aaattcttca atcgttttgc tgctatcaaa tccatctaaa
    26401 aattcaagat tcatattttc tatattctgt attgactcgt actttaagtt tccattttca
    26461 tagtattcag tacttgagaa taatacacca ttctcataaa tcaatctatt tattaaatgc
    26521 tttgactcta tattattgtt agcattagag tctttaaact taaattcact agtaaacaat
    26581 tttataagtt ctgctacttc atacttataa tcatgtcctt ttaaaaaaac atacaacatc
    26641 aacttaactc cttctattta acagtagaag aaccccctca ctaatatagt tattaaatat
    26701 tttatacttt tttaaatact aatataaaat tacatgtaag gatttgtctt cttttcaacc
    26761 cctagagtac tggttggtcc atgtccagga tatactctaa cagcatcttc atatttacat
    26821 aatttcttaa gtgatttttc catttggtta aagtctccac tatataaatc agttctacca
    26881 atacttccag caaacaaagt atctcctgtg aacatttcat cttcaactct tatacacata
    26941 catccttgag tatgtcctgg agtatgcaag aaagtcattt ttaattcacc aagttcaagc
    27001 ttgtctttat catttacata gatatctgca tcaaactctt gtgctccaca tctcattgta
    27061 taacttagat ttttattttt gtcatttaat aattcttttt catcaacatg tgcaactact
    27121 ttagcaccag ttttttcttt aatatcctta acatatccta tatggtctcc atgcccatga
    27181 gtaaggataa tatattcaat atttaattca ttttctttta caaaacttaa tgtctctact
    27241 aaacttccac ctgggtctat aactgcacat tttttagtct tttcatcacc taatacataa
    27301 gtatttactc caaaataact atctacaaat ttttttataa tcattaaagt tttccccctt
    27361 aaaaagattt acttgagtct aatagtattg ttactggacc atcattagtt aactctacca
    27421 tcatatgagc tgcaaattga cctgtaccaa ctgtcacacc tttatctttt gcttttttta
    27481 caaattcttc ataaaggtta tttgcaagtt ctggtctagc tgcattacta aatccaggtc
    27541 ttcttccttt tctgcaatct ccatataaag taaattgaga tactactaaa agctctccac
    27601 ctatatccat tagagataaa ttcatcttgt cattttcatc ttcaaaaatt ctcagattca
    27661 atattttatc aatcatataa tctacatcac ttgatttatc atcatgagtc actcctaaca
    27721 atactagtaa ccccttattt atttgaccta tagtgttttc atctactgta actttagatg
    27781 aagatactct ttgcactact gctctcatag tttcctccct attattttaa ctctaatttg
    27841 tcattctata aatactttct acaccaggaa ttgcttttaa ttttttcatt agaattttta
    27901 attcctctgt gtcattaacc tctacaagta agtttatact tacaatacta tccttacctt
    27961 ttcttgcatt tattccgttt aaactaagtt tatccattgc aacaatatga gttatttcat
    28021 taacaattcc tcttctgtca atagctttta tttgaatttc cgcttcaaac ttaccttttc
    28081 ctgctgaact ccatgaaacc tccaccaatc tattttggaa gaaatcacca ttattgtttg
    28141 catttgggca atcagctctg tgtatggcta ctcccctacc cttagtaata tatcctacaa
    28201 tttcatctcc tggaagagga ttacaacact tagcaaatct tactaagata ttgtcaagcc
    28261 cttttactat aattccttgt gatgcgtttt tctttctctt tttactgtat tctgtttcac
    28321 ttatattgtg tttatttaaa tcttcttctt gtatctgttg ttccttttta gcttttttaa
    28381 cctcttttaa atataggtct tttaccttag ataccacttg agatgacatt ataccaccat
    28441 aacctacagt ggcaattaag tcctcaacac ttggctgatt aaatttctta gcaactaatg
    28501 ccatatattt ttcaacaaga gggtcttttt gtggtatatc atgcttctta aattctcttt
    28561 ctaatattgt atttccacgg tcaacatttt cttctcttct ttccttcttg aaaaattgtc
    28621 taattctact ttttgcattt ggggtcttca ctatattaag ccaatcccta cttggtccat
    28681 tagaattaga tgatgtaagt acctcgacaa tattaccatt ttgaagctta taatcaatag
    28741 gaactattct tccatcaatt ttagctccta cacatttatt acctacattt gtatgaaccc
    28801 tataggcaaa atctataggt gttgattctg ctggtaattc aattacgtct ccttttggcg
    28861 taaatacata aacttgacta ttaaatacat cttctttaag tgcatccata aactcttgtg
    28921 ggtcttttaa atctttttcc cactccatca tctgtctcaa ccattgaagt ttttcttcaa
    28981 cctttgattc tttgctagag ataccttctt tatatttcca atgggctgct ataccatttt
    29041 cagctatatt atgcatctca tgagttctta tttgtatctc taaaggttct ccatcaggac
    29101 ctacaacagt ggtgtgtaat gattgataca tattgggttt tggcattgct atataatctt
    29161 taaatcttcc tggaataggt ctccataatg tatgaactat accaagtact gcataacaat
    29221 cctttacatt atcaaccaat atccttactg ctgttaaatc aaaaatctct tcaaaagtct
    29281 tatgtttttt ttgcatcttt ctatatatac tgtaaaaatg ctttggtcta ccatatacat
    29341 cacatggtat acttaaatct ttaaacttat ctttaagaag ttcaacaatt ccttgaatat
    29401 aatcctctct ttgacttctc ttcattgata ctctactaac taaatcataa tacccttctg
    29461 ggtccataaa tcttaatgct ctgtcttcta gttcccactt tatcttggaa attcctaatc
    29521 tatgagctat accaccataa atttcaagtg tctcttttgc tttatacttt gctttttctg
    29581 gaggcatgta ttttaatgtt ctcatgttgt gcaatctatc agcaagtttt ataagtataa
    29641 cccttatatc cttcgccatt gccaaaaaca tttttcttaa attttcagat tgagtttctt
    29701 ctttcgaacg atattttatt tgaccaagtt tagttactcc atcaaccaaa tccgctactt
    29761 ctttgccaaa ttcttttttt atgtcttcat aggtatattc tgtatcttct acaacatcat
    29821 gaagtaaacc tgctgttata gtttcaatat ctaattccat ctctattaaa atatttgcaa
    29881 ctgctaatgg atgaataaag tatggttccc cagattttct atattgtcct tcatgcgctt
    29941 tttttgcaag attataggct ttttcaacca tttcaaaatt tgcattaggt gcataaactt
    30001 ttattttttc aattatttct tgtaattctt tatcatgcat ataaccacct attttgtata
    30061 aaattttaat atatatgaaa atagttggtg ttataccaac tattataaaa gtactagtat
    30121 tttataagag aattaacatc atagttagac aacttttctc tcccatttaa gaattttagc
    30181 tcaatcaaaa attgcataga aactacttct ccacctaatt tttctacaag cttggcagcg
    30241 gcttccatag ttccaccagt agccaataaa tcatctacta ttgctacttt ttgacccttt
    30301 ttaattgcat ccttatgtat ctctaaagta tctgtaccat actctaatcc atactcataa
    30361 ctctcaactt cacctggtaa ctttccaggt tttctaattg gaacaaatcc tactcctaaa
    30421 gcatatgcta caggtgtacc catcaaaaat cctcttgctt ctggtcctat tactaaatct
    30481 acatctttat ctttcaattc ttcaactata gaatccactg catatttaaa tgcatctcca
    30541 tctttaaata gagttgtcac atctttaaaa tctatgcctg gctttgggaa atcatcaata
    30601 ttccttataa agttttttaa atccatggga aacgcctcct aataactgct attgtattgt
    30661 ttttctaaat tttttagatt attgagtatt aaactctcat ttaagtctaa ttttttctgt
    30721 ggttttggca atattcttat gagtacagaa tttttttcat aatttaaatt aaagtcaagt
    30781 aaatttaatt ctctaaatac atttaatatc gtaaaaaact ttaatggaat tacattaaaa
    30841 gtttccctta tatttaccat atccaaatca atttcttttt ttatgagtgc ttgtttataa
    30901 attgttataa attcatctct tgatggaact atattactaa ctacattctt taaatataat
    30961 aggtctgttt tattataata ttttataatt tcactttctt ctcttttatt ctcatatata
    31021 tacgaatatt cgcctttatt gtataaataa tcataaagaa taatattatt atatcttttt
    31081 aagtctattt tatcaatatt aggagaaaat ataagctcta atttatcagt atttttgcta
    31141 acatcttcaa taatattgta atttatgtta aaatccaaat ctataagtga tatatctgac
    31201 attgctctat aaaatccatt tatagaatta gatattatta gtgtatcttt ttcaaaataa
    31261 tcaaatatat ttatatctgt atttccatca aataattcaa aatcagacac agatatatta
    31321 tacaggcttt gagtatcttt tggtattatt tttgacatta atttcaatga aagtttgtca
    31381 ttacttgcac ttttaggtcg agctaatcgt atatctttaa gtaaaaattg tactttccta
    31441 tttcccatat agttattttc atctaattgg aatagtacat ctactttgtc tcctacttta
    31501 tacattgatt ttaaatgact catattaaat cctatacatt catagctttt ctctttttct
    31561 atacttaatt tcagatgttg ttgattctta cctataactt tcaaatcttt taaaatataa
    31621 tttctaacta taaatctagg attaggatta tttaatccaa agggttctaa cttatgtaat
    31681 tcttctacaa gatttaaatt tattacattt tcttgtaatt caaactcgac atttacattc
    31741 tctatcatat catcttcagt taaattataa tctgcaaatt tatttatttc atttgctaaa
    31801 atttctacat tgtctgaatc caaggataac cctgctgctt gttcatgacc accaaactta
    31861 gtcatcaagt ctttgcactt tatgagagct tcaaatatat taaatccttt tattgacctc
    31921 gctgaaccag tagcctcccc attttctata cctagaagaa ttgttggttt gtagtatttt
    31981 tcagttaact ttgatgctac aattcctatt attccatgtt gccaaccctc tttagctaaa
    32041 accaacacct tgtcatcatt gtatctgcta ttagacttta gcatttcctc agcttcatga
    32101 tacatcttag cttctatcat ctgtctttca ttattttttt cttccaatat actagctatt
    32161 tctactgcct cttcttgtga ttgagtagta aatagctcta ctcctaagta agaatatccc
    32221 aatcgacctg aagcatttat cctaggacct attgcaaaac ctatatgaga agaacctatc
    32281 ttatcacttt ctacaccaca aacttttata agctccctta atccaatatt tttgccttct
    32341 ttcattgatt ttaaaccatt ttttacaatt attctatttt catctataag tggaacaata
    32401 tcacaaatag ttgctagtgt tactatttcc aaataattat acatactagt tttaaattct
    32461 tcttttggag tcaaggcttg aatcatttta aatgctacac cacatccaca tagtgaatca
    32521 aatggataat tacaatcttc ttgttttgga tttattactg caaaggctga tggaatttca
    32581 ctttgacatt catgatggtc tgtaattata acatctatgc ccaaatcatt cgctgtattg
    32641 acctcagaca ctgatgtaat tccacagtca acacttataa tcaagtcaca tcccctagag
    32701 cttataagct taatagcatc ttcatttata ccataccctt cttctaatct attaggaata
    32761 tagtaatcaa cattgtaacc tatactctta aaatataagc acaagataga tgtagatgat
    32821 acaccatcaa catcataatc tccgtaaatc caaatttttt cgttcttctc aactgctaac
    32881 tttattctat caacagcttt ttgcatatct ttcattaaaa aagggtctct taaataatct
    32941 aaagatggat tcataaatat ctctgaatct ttttcagtac atatccctct attttttaaa
    33001 atttggcaga tttccgggga aatattaagt tttttgctaa attcactttc ctctatctta
    33061 cctttatact tcaatatcca ttttttcaaa tttaattccc cctaatcttt tttgtatttt
    33121 gacctaatac ttcttataac taagcaaagg cctattataa aggatataaa gaaacccgct
    33181 attgcagtaa attttatcca tatattattt tctatatttg gagatgcaat tataagagaa
    33241 gaacctacta taatagatgc caacactaaa ctcaaagata tttgagatgt tagctctatt
    33301 atacaatttt ctaacctcgt cattttaaca tcttcaattt gcatttttat attatttctt
    33361 tctatatttt ttaaaattgc ttttaattgc tttggaatag tttttatgtc cagtaatatt
    33421 tcttctacat tttgtcttga acttaaaaca acatttttag ggttaaattt actcttataa
    33481 tgatgtttca taaactcttt tcccatagaa ccaaaagaaa aatctgtgtt taaagttcta
    33541 cttgttcctt ctaatgttat aactgtcttt gcaagagtta caaattgtgc aggcatgact
    33601 attttatact gtctaaaaaa cctaaatagt tcatttaata tatctgttac atttattttt
    33661 tctatagaaa tatcatagta ataatgtatt agataaagta aatcctgtct aagtccctta
    33721 atatcagcct ctccatttaa tgcatccatt tctatcaata gatatattat cttgtcaaca
    33781 ttcttttcta cacctgctaa tgcaatttca tttaattggt ttaaagtttt attatcaata
    33841 attccaatca ttccaaaatc tatatatgct atcttatttt tagcaattac gaatatatta
    33901 cctggatgtg ggtctgcatg aaaaaatcca tgagataata cctgtgtaaa aaatgaccta
    33961 acgcctattt caacaatagt ttttgtgtta taacctagtc tccttatttt ttctacatca
    34021 cttaactttg taccattaac tttttccatt actaaaattt tcttagtatt atattctgaa
    34081 tatactttag gtatatatac ttcatcacta tttttaaata tcctagagaa tttagttgca
    34141 tttatagctt caaatgtata atcaagttcc ctcattaatt gagtttgaaa ttcttcaatc
    34201 atctgtacta aatctaaatt aaaatccttt tttaaatctt ttaaagtatt tgcaatagtt
    34261 ctaagaatct ctaaatcaga ttttattatt ttctctatat ttggtctttg aatttttacg
    34321 attacttctt ctcccgtttt aagtacacct tcataaactt gaccaattga agctgctgct
    34381 attggttctt ctttaaattc taagaatatt tcttctatac ttaaacccac ttcttcttta
    34441 aatatatcaa tagctatatt tgaatcaaat ttctctacat catctctgag ttttgatatt
    34501 tcatcaatta tatcctggtc taacaagtct tttcttgtac tcaatatctg tcctattttt
    34561 atatatgtag gtcctagttc ttctaaaact cttttcattc tctcaccagt tgtcatattt
    34621 tttatttctt ctggtgggtc aaatagtggt attttatagg caattccttc tatatttagt
    34681 ctttctacaa taaaactaaa accatacttt attaaaacat atccaatttc tctatatcgc
    34741 tttaaatttc tataacttat tctcaaatct tttcactcct aagataggta tacccaaaaa
    34801 cttacacctt aatttatcgt atatgacatt atttcaccaa ttgatattct aatatcctat
    34861 atcctcttta atatttaatt ttatcacata tactaccaat tttattaaaa ttatttaact
    34921 cagttaattt ttatttttga cattttatat ctggtttaat caaatacttt ttgaaaacta
    34981 aaatatcaac aaaatctaat aaaataaatt agtggttgcc tcaaaacaga tttaaatatg
    35041 ttttgaaaca accactcttt aaactaatat ttttgatttt gtgctgcctc taaataccat
    35101 tcataagatt catcaatata ttttttatct tcttctgtaa gctctctaac aaccttacca
    35161 ggagaaccca ttatcaaaac acctggtgga aacttcttat tagatgtaat tagtgtacct
    35221 gctcctatca gagtatattc tcctatttca gcattatcca atattattga acccatacca
    35281 attaacacat tatcactaat tttacaacca tgaactatag acctatgccc aactgttaca
    35341 ttgttaccaa ttatagtttc tgtatctcca tgcactatag aacaatcttg tatattagtg
    35401 ttttctccaa tagttattgg tccttcatca cccctaacta ctgcattgta ccatatactt
    35461 gaatctttgc ctattttaac atttccaatt acatctgctg attttgccac aaatacactt
    35521 tcgtcaatta aaggtttatc ttctaaataa tctctaatca tatataaaca actcctttaa
    35581 aatataaatt tagttggttg ctccttctaa cattaactta gcttgtatca ttatagagca
    35641 ctctgtacgt tttctttgca tttcacagcc taattcatat ggttttgata tgtcattatt
    35701 aaagtttatc gcatttgcat gacatccacc tgaacagtaa aacttattcc aacattgttt
    35761 acactcttct ttagtatata catgagcttc tctaaacata ttttttaaat tttctggaag
    35821 tactatttct tcatcaaata tatttgccat tttaaattct tcatttccaa caaattgatg
    35881 acatggatag atatctccat ttggagttac agaaagatac tcatttccag ctccacatcc
    35941 agttattctc tttattacac atggaccttg atttaggtct atcataaaat ggaaaaattt
    36001 aaatccatct ccttgtaatt gtctatctgc atactctaca gcaaattttt cgtactcttc
    36061 aaatatctta ggtaaatctt cttctctaag tgcatatgga ttactctcat ctccaacgac
    36121 tggctctaca gaggttaatt taaatcctaa atctgcaaaa tgcataacat cttttgaaaa
    36181 atctaaatta tcccttgtaa aagtacctct tatataataa tacttatctt ttgctctttt
    36241 ttccacaagt ttcttaaatc gtggtaatgt aatatcataa cttcctttat catttaaagt
    36301 tggtctcata ttatcattaa cttcttttct tccatctaaa cttaaaacta cattatgcat
    36361 attttcattt atataatcta taatctcatc atttaacagt acaccatttg tagttattgt
    36421 aaatcttata tttttattat aatctttttc tacacttctt ccatagtcaa ccagttgttt
    36481 tacaacttca aagttcatca aaggctctcc accaaagaaa tctatctcta ggttctttct
    36541 acttcctgaa ttagcaatca aatagtcaat tgctgcctta ccaacttcaa aactcataag
    36601 ttctttttct cctccaaaat caccttgagc tgcaaaacag tatttacatt ttaagttaca
    36661 atcatgagct acatttaaac ataaagcttt tactacaggc tctctatgta caaagcttgg
    36721 atgatattga tatgtatctt ctgtatataa aagaccctct ttttccaaat ttaatatttc
    36781 ttcatatgct tcatttattt tttcttcttg atattttgat tttaatatct ctaatatttc
    36841 ttctttactt ttttctttat aaaaatctaa caaatcgtat gcaacatcat ctaacacatg
    36901 aacagctcca ccattcacat ctaaaacgat attatatcca ttcatagaaa acttatgtat
    36961 catactcata ctctacctcc taaattacta tctatactaa agttttttat tattttaatt
    37021 aaactttacc cttcattata tcataagttt acataaaata catacaatac aaaaatgact
    37081 tactctccgt aagtcatttc attaaataca ctatatcccc ctaaattggc gcactaatat
    37141 attaccaaat aggtattagg ctcctataaa ataaataaaa taaattttgt atctgatttt
    37201 atattgtttt aatcttatta aaatataata atttcttttt tcctgataat tttgtataaa
    37261 taagtgcttg tatttaattt gtcttcttta gattgctgat ttctttgggt actttaggct
    37321 gatgaataat ccaaggacag gtactattag ctgacaaaat agcagtgcta agtgccaatg
    37381 agctagcaaa cttcataaat cttacaataa actttttcat aacttaactc tccctcatac
    37441 atattttact tatactttag cttttaactt acctaatact aacatcacaa aaatccaaaa
    37501 catggcaaat gcgctatatg tgaaataatc tacaaatata ctcaaagaaa gacttaaaat
    37561 tgttatcaat aacactactg tagatataaa tatagcagtt ttcttataaa ccaacttttc
    37621 cctatcactt atagggttac tcctatgttc tattgggcac agaacacaaa ttccaaccca
    37681 actaacactt gcaataatca taataatatt tttaaataag tctatattta tattttctat
    37741 aattaagatt gtggataaaa ttataaaaat aaaggttaat aagcatctaa aataattgtc
    37801 tgcatgatac cctcctgaaa attgtcttat tggacaataa cacattaaaa aaaataatac
    37861 atatgtaaat ttaccaaata aaaaacctat aaacagcatg gtggttatat taactatgaa
    37921 agctattaat atttcaaatc cataagaata gactttagat tcattattat ctatcatatt
    37981 attacaaatt aaaacagatg tcattttttc agcatatctt ttaaacattt ttacctccaa
    38041 aaaaatttta catatataga gtacattctt ttttgagaaa attcaatata ctttacaaaa
    38101 ctagttgtta aaaatgtaaa actggtcaaa aaaagaccta tataattttc ttcttattat
    38161 ttatataaca aaacaattat aataaaacaa ttttatcaag ctttatatgc ataaaaagcc
    38221 tatgtcaaaa tagaaataaa ccttttcccc attgttaaaa gtctaaaaat atattttatt
    38281 tcatataaaa agagtacctc acaaactaaa aagttccttt tgagataccc attttattta
    38341 ttacaaaata tcaaatttta tttatttgca tatattttct atatatttta gccttttaac
    38401 tttgtttttg ttttacatac tgtagtgctt ttctattctg ttttactgct tcaagacaaa
    38461 ctttttctgt ttgattatca acaaattcta aagctctata attttgcttt actgcttcta
    38521 aacatatttt ttctgtttga ttatttacat atttcaacat tctataatct tgttttactg
    38581 cttttagaca aacttcttct gtttgttctt tcacatattt aagcgcttca taactttgat
    38641 taactgcttc taaacaaatc ttttctgttt gttcctttac ataagctaaa gcattatagt
    38701 tttctcttac tgcctctaaa catattaatt ctgtctgatt ttctacatat ttaagaattt
    38761 ttccattttg ctttactgct tctacaaata ttctttctgt tggtatcttt acataactta
    38821 atatttcttt tatttcaagt tcttcaaatg aacctcttac tgcttctata catatatttt
    38881 cagtctgttt ttttacatat tgcagtactt ttccattttg tctaactgac tccaagcaaa
    38941 tttcttctgt ttgctctttt acgtactgta atgctcttcc atcaattctt actgcttcca
    39001 aacaaatctc ttctgtttgc ttatttacat actgtagagc catataactt ctttttactg
    39061 cttccataca tattttttct gtctgttcat ttacataata caatgcaaag tcattctgtt
    39121 ttactgcttc tatacatatt tcttcagttt gctcttttac acaagatagt gcactgtagt
    39181 tttcttttac agcttctaaa catatactat tactttgttc ctttacataa gctaaagatt
    39241 ttccatcttt ttttacagct tctaaacata tggctggagt ttgctctttt attcctttta
    39301 atatctctgc aacatcattt ttagatgccc tttctataaa tgctagacat acatcttctg
    39361 tttgctcttc cacaaattta aatacttcca tgacatcata agttgatgca ttttttatag
    39421 cctcaattag tacattttct gtcttattat ttatgtagta caaagctctg tagttctgtt
    39481 ttactgcttc tatacaaata tcctcatttt gatttgttat atacttaaga gatttatatg
    39541 tctgttttac tgcttccata catactttat aagtcttgtc ctttacaaac tcaattatag
    39601 taccatcctg ctttactgct agcagacata tctcttctgt ttggttttct atgtctttta
    39661 actctctgta atcatatttt actctactta aatcatttaa atgtactttg ttatcttcct
    39721 ttaaatcttc ttcattattt tctatatcat actcaaattc ttcatcatct aaatagtcat
    39781 ttttttctgg taaaaatata gatttaattt tattctttat atccataaaa ttatcctcct
    39841 ttaatatgat tctatcatta aagtaaatcg tttttaagca cttatttaat taattttata
    39901 ttaagtttat ttaaaagtct attcattgtc gatagattat attttatatt aataatttta
    39961 tcttatatat gtggggtaat aaagttaata gtggacattt tccatcccat tagtatacac
    40021 tatttatatt tattactcat ttatagtgat tttt
//
LOCUS       DAEQCW010000027        39176 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.027, whole genome shotgun sequence.
ACCESSION   DAEQCW010000027 DAEQCW010000000
VERSION     DAEQCW010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 39176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39176
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.027"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(62..490)
                     /gene="ytfJ"
                     /locus_tag="KRO40_001397"
     CDS             complement(62..490)
                     /gene="ytfJ"
                     /locus_tag="KRO40_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerW family sporulation protein"
                     /protein_id="HBH2092219.1"
                     /translation="MRATGSIQSLMETTLETIKGSIDANTIIGDPIKTDTTVVVPISK
                     VTIGFGIGGGEYSKGYDDKDREIELKNEKSDTNFAGGSAGAISVQPVAFVVVESGETR
                     IMSLDSNINLVDNILSITPRVLEKIQNISQSNKNQDKNNM"
     gene            complement(444..1073)
                     /locus_tag="KRO40_001398"
     CDS             complement(444..1073)
                     /locus_tag="KRO40_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2953 domain-containing protein"
                     /protein_id="HBH2092220.1"
                     /translation="MELNELFNFKYLIIAVIFIISVTMLILISHINILIIADIKNKDI
                     CLKLNIKYMFNLININRQLYPAENSKNNDKKEGMKNNIDSSILLADDLLSIYRLLKKI
                     KIHELYSNINFGTGNIGLTSSVYVLINTLYGNLFNMIDAEKMYLNVNPDFTKDYVLGN
                     IRIHIRPRIKALFNIIIMINKIMNKNKGNKEGDSNESNRFDTESYGNNS"
     gene            complement(1235..1774)
                     /gene="scpB"
                     /locus_tag="KRO40_001399"
     CDS             complement(1235..1774)
                     /gene="scpB"
                     /locus_tag="KRO40_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="HBH2092221.1"
                     /translation="MKREDIKYIIESVMFAYGEPISIKELNYIINKELSSKEIEIMLN
                     LLIEEYREQNRGIQIIKLENKYQMCTNKDYAEYIKKIIEPKKKKSLSQATLETLTIIA
                     YKQPITKVEIEDIRGVKCDKVLQTLFENELIREAGRLNKIGKPIIYKTTDEFLKLLNI
                     ESLEELPPIENYQEVATNE"
     gene            complement(1776..2495)
                     /locus_tag="KRO40_001400"
     CDS             complement(1776..2495)
                     /locus_tag="KRO40_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HBH2092222.1"
                     /translation="MKYNIQLQVYEGPLDLLYDLITKHKIDIKDISIIDITKQYLNYL
                     KMLDKMDLEITSEFITMASKLLEIKSKYLLYKQKDEEEDPRIELMEKLEEYRKFKVAS
                     QDIKENITYVNERFYRNKEEIIIDDNVDLEDISIEAIKNILPYIFKVKTSQIENANDE
                     KLDKIVRKKIISVEEKILYIRDIIKDKIEVTFTNIIKSYENDEIIATFLSILELIKEK
                     EIVVVQDIFFDDILIRKSSEC"
     gene            complement(2525..3121)
                     /locus_tag="KRO40_001401"
     CDS             complement(2525..3121)
                     /locus_tag="KRO40_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HBH2092223.1"
                     /translation="MLSMNIGEIVASLVGIAMAISIHEFGHAYSAHLLGDDTAKAYGR
                     MTLNPVRHVDPIGLLAMFILKIGWAKPVPVNPNNFKNYKIGNLIVSLAGVFCNVLTAI
                     LCVIINKYVHMYAINTIAGYVLLYSMGFAAFNLLPIPPLDGWGVISTFVPYKWNEYLY
                     KFESMSYIILLIALFTGMYRIILSPIYTVLLKIVYLFV"
     gene            3419..4255
                     /locus_tag="KRO40_001402"
     CDS             3419..4255
                     /locus_tag="KRO40_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2092224.1"
                     /translation="MRQEERTVCFDRELKIEAYRFKGIMQKFPNHFHEHYVIGFIEKG
                     QRYLSCKNKEYTTSTGDLLLFNPFDSHTCEQIDDKVLDYRCINIKPEIMKKTVFEITG
                     KNYLPKFNQPVIFRSELVPLLQELHYIIMEEELDFKKEELFFFLIEQLIEEHTEPNLQ
                     SNLENTNIEIQAVCDYLENNYAEHIVLDELSTIAGMNKYSLLRNFTKLKGITPYRYLE
                     NIRVNKAKKLLEKGVEPIDAAIQTGFVDQSHFTNFFKNFIGLTPKQYQNIFINDDSNN
                     FK"
     gene            4276..4698
                     /locus_tag="KRO40_001403"
     CDS             4276..4698
                     /locus_tag="KRO40_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2000 domain-containing protein"
                     /protein_id="HBH2092225.1"
                     /translation="METKNSKCVMVIDENLPMGIISNTAAIMGITLGKHAPETVGPDV
                     IDKTGNSHLGIIDIPVPILKGNKEIIKDLRKKLYTLEFNDLTVVDFSDVAQSCNLYEE
                     FTQKIASVPEDELQYFGIAIYGNKKKVNKLTGSMPLLR"
     gene            complement(4909..6072)
                     /locus_tag="KRO40_001404"
     CDS             complement(4909..6072)
                     /locus_tag="KRO40_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH2092226.1"
                     /translation="MKKLASTALAILIALTPLSFSFANNKENADANQLNISSKSAILM
                     DVGSGQILYEKDAHKKLPPASVTKVMTMLLIVEALDSGKIKLDDEVQVSETASSMGGS
                     QIFLEPGETQKVDTLLKGIAVASANDACVAMAEHLAGSVEGFVDRMNAKAKELNMNDT
                     HFANTNGLPVANHYTSAHDIALMSRELLKHEMISKYLTTWMDKVVVGKKQVTVGLANT
                     NKLIKHYQGATGVKTGFTQEAKYCLSASAKRGNTHLVAATLGAETSPERFNDASSLLN
                     YGFANYESVKLCSKGDNIATLTLDKADENKVKLVAKEDLNALIKKGSSKEFEKKIEIV
                     KNPKMPIKKGTVLGKIKICKDKKVIGEVELINTKDINKASYLQMLQRIIDNMI"
     gene            complement(6126..6326)
                     /locus_tag="KRO40_001405"
     CDS             complement(6126..6326)
                     /locus_tag="KRO40_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protein"
                     /protein_id="HBH2092227.1"
                     /translation="MDDVSRQNAIKALKQTKMEIAGEYGMNYEDAFEIIENASNKGVL
                     EGYFKKLEKKKNLGQGISRHLE"
     gene            complement(6532..8208)
                     /locus_tag="KRO40_001406"
     CDS             complement(6532..8208)
                     /locus_tag="KRO40_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HBH2092228.1"
                     /translation="MQLFKKNTNKIKVMALGGLNEVGKNMTVVEYKDEIIVIDAGLSF
                     PEDEMLGVDIVIPDITYLVKNRDKIKGIFITHGHEDHIGALPYILKKINVPVYGARLS
                     IGLIQVKLKEHKMNNVKLNVIGPRQVIKLDNMEVEFLKNNHSIPDAYSIAIHTDQGII
                     YHTGDFKIDLTPIDGDVMDMHRICELSKKGVLLMLADSTNAEKPGFTMSEKTVGVGLD
                     ELFAKGNGRRIIVATFASNIHRLQQIINTAEKFNRKVAISGRSMVNVVGVAKELGYLD
                     ISDDMLIDLNDICKYEDSELVIITTGSQGEPMSALARMAFSEHKKVEIKSGDLVIISA
                     HPIPGNEKLISRVINFLFEKGAEVVYSDIADIHVSGHACQEELKLIHALVRPKFFMPA
                     HGEYRMLKRHAEIAEQLGMDKENIFVMQTGDVLELDKNSAKVANRIQTGNILVDGLGV
                     GDVGNIVLRDRKHLSEDGLMIVVVTISKDEGKVLAGPDIISRGFVYVRESEDLMDGAK
                     DIIKNVLNECEEKNIKEWAYLKNNIKENLKEYLYQKTKRNPMILPIIMEV"
     gene            8425..9162
                     /locus_tag="KRO40_001407"
     CDS             8425..9162
                     /locus_tag="KRO40_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBH2092229.1"
                     /translation="MRGKTHCAIGILTAIQTSLIFKIPISLVDILVSATFAVLPDLDK
                     SNSMVSNFILKNNVSKYIYRIFIYAVNIIIFFISININDNFYLSAIITFVAIIIIEAK
                     LTHTFLRKVFLSLIFILLAICLYIIEVEIYFTIFCLMLSIFPWLKHRSFSHSIFATII
                     VYFLLKQIELITNINNLSFYGTIGYASHMFLGDLFTKQGIPIFYPLSEKKISLGFLTV
                     GGPFSNFIEKSFIFVLIGLIIFSILKL"
     gene            complement(9279..9737)
                     /locus_tag="KRO40_001408"
     CDS             complement(9279..9737)
                     /locus_tag="KRO40_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBH2092230.1"
                     /translation="MANTMDLLKDKLKETGFKITPQRRAIVEILLKHDHSHLSSEEIY
                     DLVRVDCPEIGLATVYRTMQLLDEIGLISKLNLDDGCIRYEISLHKEDCHNHHHLICK
                     NCGKIMEAKEDLLDNIEKEIQSLYKFKILDHDVKFYGLCDECNGVSDSEE"
     gene            complement(10019..10306)
                     /locus_tag="KRO40_001409"
     CDS             complement(10019..10306)
                     /locus_tag="KRO40_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HBH2092231.1"
                     /translation="MEENIINLIDENGVESQFEIILTLEAEGKEYAILMPLDDEEAEE
                     ALIFRIDEDEEGEILIPLESDEEYETVVAVYTAIMEEEGLNYDEDESNGLN"
     gene            complement(10384..10809)
                     /gene="ruvX"
                     /locus_tag="KRO40_001410"
     CDS             complement(10384..10809)
                     /gene="ruvX"
                     /locus_tag="KRO40_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HBH2092232.1"
                     /translation="MLDGRIMGLDVGDKTIGVAVSDLMGLTAQGVKTIKRVGKKKDIE
                     ELKAIIKEKQVNKIVSGLPKNMNGTLGPQGEKVIKFCELVKAETGIDVEFWDERLSTV
                     AAERSLLEADVSRQKRKKVIDMLAAVIILQGYLDFKINS"
     gene            complement(11015..13186)
                     /locus_tag="KRO40_001411"
     CDS             complement(11015..13186)
                     /locus_tag="KRO40_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092233.1"
                     /translation="MRKKIMSLFAIVIMIFVSTASYGFAEEKGKVIFIDMNRTNLGSM
                     MNIPILKNEIEKRGYVALMNIRGDQGTDDRRSYASMGAGTRASVTTEDYINFQKVDQD
                     TAKAFEVATGQKAKEINDLGINRSINENLEYGEYGANLGSLGKTLSENGLKTSVIGNA
                     DIIENNQLVKNRNLCLVAMDQYGRIDSGNIDNINKKDSKMPFGISTDYDKLLDETKKS
                     YKNSDAIFVELGDTYRLDMYRLNLNDNTYDTMKKNIVKNINKYLEQVFSMVGENDTVY
                     IASAFPSDLDYKNKRRLSPIIKFSGEGKGLLESATTRKAGIVANLDVGVDILGTFGLE
                     NKEMVGRSYTLVNKEDNISYLKSLYERIVSISSIRSTIINGFVGVISASWVIAMFAIF
                     FRNYMPHKERVFKVLKEFIKLGIIMPLSFMLAPLMNFKTPISISLGIFATTLILYLLG
                     RKLFKDNDIKHMGFFATLTILVIVIDSVFGTYLMQNNIMSYDAVIGARYYGVGNEYEG
                     VTIASAVFGLAVLLHYKKVSKLLVVIFSLIILITSAYPSMGANVGGAISECVAYLLFI
                     MLIYDIKIDFKKAVLLAVSAVVVVFAFAALDILSGSESHLGMFVQRIFLNGPGEILQT
                     FGRKIQMNMQLAQTSVWVNILLVGIGVIAVLIFKPSRHFRKIMNNFPILFKGFIASMV
                     GCIITLLVNDSGIVAASTASIYILIPLIIISINMIIFEKNN"
     gene            complement(13196..13453)
                     /locus_tag="KRO40_001412"
     CDS             complement(13196..13453)
                     /locus_tag="KRO40_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HBH2092234.1"
                     /translation="MEKDLDYTMKFEGIPEDRMSVGDTIDFVYKALVEKGYNPINQII
                     GYLLSGDSSYITSHKNARAIIKKFERDEILEEVITHYLNRK"
     gene            complement(13478..16117)
                     /gene="alaS"
                     /locus_tag="KRO40_001413"
     CDS             complement(13478..16117)
                     /gene="alaS"
                     /locus_tag="KRO40_001413"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HBH2092235.1"
                     /translation="MEKMGLNEIRSKFLEFFESKGHYVANSYSLVPNNDKSLLLINSG
                     MAPLKNYFSGVEVPPSVRMCTSQKCIRTGDIENVGITARHATFFEMMGNFSFGDYFKR
                     ESIKWGWEFVTEWLNIPEDKIWVTVYEEDDDSYDIWAKEMNFPEERMVRLGKDDNFWE
                     IGTGPCGPCSEIYFDRGEEYGCDNPDCKPGCDCDRYLEFWNHVFTQFDRDEEGNYSLL
                     ENKNIDTGMGLERMGCIMQGVDTIFEVDTIKSILEAVEKLTGVKYGENPKNDISIRII
                     TDHIRAVTFLVSDGVLPSNEGRGYVLRRLLRRAARHGKLLGVKELFLQKLIDEVIKVN
                     DKAYPVLVEKESYIKKVVGIEEEKFNETIDQGTEILNSYIEVLKNEGKTVLSGQEAFK
                     LYDTYGFPIDLTKEILEEEHLSVDEEAFNEEMEKQKERARNARGNMDRESWKEDPLSK
                     LESTVDSTFNGYSEIYGEGTIEAIVKDDELVQSAEEGDKVSIVLDNTTFYPEGGGQVG
                     DCGLITNENLVLEVLNTKKGANNSIKHIGIIKSGRISNGDKVKTLVDRETRMSAARNH
                     SATHLLHKALREVLGEHVNQAGSLVTPERLRFDITHFEAISNEELKVIEEKVNNVILS
                     SLDIKCDIMNIKEAKEKGATALFGEKYGDEVRVVSMGDYSTELCGGTHLTNTSQVGMF
                     KILSEGGVAAGVRRIEAITGKAVYEYLKERDGIISEVCVNLKSKEDNLIQRISSLLEE
                     NKNLSKELHDMKAKMSLQSVDSIFDSKVEVNGVNLITNKFEGMDMDTLRETADNLRDK
                     LGSGVVVLANVVDDKVNFVVTATKDVLDKGIHSGNIVREVAKIAGGKGGGRPNMAQAG
                     ASDVSKVDQALSYASEVIKTQVK"
     misc_binding    complement(16185..16423)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(16566..17645)
                     /gene="mnmA"
                     /locus_tag="KRO40_001414"
     CDS             complement(16566..17645)
                     /gene="mnmA"
                     /locus_tag="KRO40_001414"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HBH2092236.1"
                     /translation="MNKKVMIGMSGGVDSSVAAYLLKQQGYDVIGVTMKLWQDDDVVE
                     IEGGCCSLSAVEDARRVANKIGIPFYVLNFREVFKEKVIDYFIDEYLEGKTPNPCIAC
                     NKHIKFDDFYKKARQIGCDYVATGHYAKIEKDESTGRYLLKKSVTDKKDQTYALYNLT
                     QEQLEHTLLPIGDYEKDRVREIAKEMGMAVHNKPDSQEICFVKDNDYANYVKKHSKKR
                     IEEGFFVDTKGNILGKHKGILYYTIGQRKGLGITFGKPMFVIDINPINNTIVLGDNED
                     LFKKELIAKDVNFISIDTLEEPLRVQAKIRYSAKPSPATIHRVGEDTIKIVFDEAQRA
                     ITKGQSVVMYDGDIVVGGGIIEKSL"
     gene            complement(17934..18374)
                     /gene="nifU"
                     /locus_tag="KRO40_001415"
     CDS             complement(17934..18374)
                     /gene="nifU"
                     /locus_tag="KRO40_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly scaffold protein NifU"
                     /protein_id="HBH2092237.1"
                     /translation="MQYSDKVMEHFMNPRNMGEIDNASGVGEVGNPTCGDIMKIFLDI
                     DGDVIKDVKFKTFGCGSAIASSSMATEMIKGKTIKDALELTNKAVAEALDGLPPVKMH
                     CSVLAEQAVKAALIDYAQKNNIHIPELDGYVIDDAHDHDVEEEE"
     gene            complement(18428..19621)
                     /gene="nifS"
                     /locus_tag="KRO40_001416"
     CDS             complement(18428..19621)
                     /gene="nifS"
                     /locus_tag="KRO40_001416"
                     /EC_number="2.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase NifS"
                     /protein_id="HBH2092238.1"
                     /translation="MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGRE
                     AKDALDKAREQVAALINAEPSEIYFTAGGSESDNWTLEGVAYANKNKGNHIITSKIEH
                     HAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
                     PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIR
                     KGVRLHNFVHGGAQEKSKRAGTENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLID
                     GVLERIPYTRVNGSLENRLPGNANFAFQFIEGEGILLLLDMLGIAGSSGSACTSGSLD
                     PSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKK
                     QGLVK"
     gene            complement(19639..20085)
                     /locus_tag="KRO40_001417"
     CDS             complement(19639..20085)
                     /locus_tag="KRO40_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBH2092239.1"
                     /translation="MKLSTKGRYGLKAMFELALNQDNGPVSLKFIAKKQKISDQYLEQ
                     IFSSLKKSGLVKSVRGAQGGYLLSKNAEDITVGDILVVLEGPVALSDCVLDEDVCENS
                     NMCVTKIVWEKMKKGIEDVIDSITLKDMINDYNKNKLENDITNIKK"
     gene            complement(20194..20964)
                     /locus_tag="KRO40_001418"
     CDS             complement(20194..20964)
                     /locus_tag="KRO40_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2092240.1"
                     /translation="MIIKLNSTYHSRVMKYLKKEPEYNLFIIGDIERYGYGNNFLNIW
                     ADVGEHGEIKAILLKYFEFMMFYSDGEYDVEGFYNLLRNTNYEEISGKICAVDALAKR
                     LGLNNLKVVDFCKLQTKKFLIDNNCNAKVKRIRLGNLKKTVKLYDLIDEFHSTTLENL
                     KNGLRTGRGYCIEINKQVVSMAKSTSENRTHAMIIGVGTHPKYRAKGLATKCLIKLCS
                     ELLRENKIPCLFYDNEEAGKIYKKLGFENIGKWGIYSK"
     gene            complement(20995..22260)
                     /locus_tag="KRO40_001419"
     CDS             complement(20995..22260)
                     /locus_tag="KRO40_001419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HBH2092241.1"
                     /translation="MPLADKIRPKTMNDVIGQSHIIGNGKILSKILQSNFLPNMIFFG
                     PPGVGKTTVAEIIAERSNKSFYKINATNSSLEDIKKVISELGSINNVNGVLLYIDEIQ
                     SFNKKQQQSILEFMENGSITLIASTTENPYHYVYKALLSRSTVFEFKPLEKLDIEKGL
                     KRAVEVLNEDSYMDIECNNNAIEDIAILSDGDMRRALNILEVVVYSTKPNKDNITYID
                     SDVIRASTFNKIINYDKNGDSHYDILSAFQKSIRGSDPQASIHYLARLIKGGDLISIC
                     RRLLVIASEDIGLAYPNAIVIVKACVDSAMQLGFPEAKIPLAEATILLATSPKSNSAC
                     IAIMKAMDELDKEFVKDIPNSIKDAHYSGSKEIGRGCGYKYPHNFKNHYVKQQYLPDS
                     IKDSIYYIPQENKTEKNIKKYLEYLNSDF"
     gene            complement(22367..23152)
                     /gene="codY"
                     /locus_tag="KRO40_001420"
     CDS             complement(22367..23152)
                     /gene="codY"
                     /locus_tag="KRO40_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HBH2092242.1"
                     /translation="MASEVLQKTRKINKTLQTSGGSSVSFDLLAGALGDVLSSNVYVV
                     SAKGKVLGLHLNDVQDSSVIEDEYTKQKKFSDEYTQNVLKIDETLENLNGEKILEIFP
                     EEHGRLQKYTTVVPILGSGQRLGTLVLSRYSNSFNDDDLVIAEYSATVVGLEILRAIG
                     EELEEEMRKKAVVQMAIGTLSYSELEAVEHIFAELDGKEGLLVASKIADRVGITRSVI
                     VNALRKFESAGVIESRSLGMKGTHIRILNDKLTDELKKLKNNQ"
     gene            complement(23317..25404)
                     /gene="topA"
                     /locus_tag="KRO40_001421"
     CDS             complement(23317..25404)
                     /gene="topA"
                     /locus_tag="KRO40_001421"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HBH2092243.1"
                     /translation="MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLG
                     VDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLD
                     ESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVR
                     KGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKI
                     ELENEEAVNQILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKT
                     MMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGD
                     KKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVF
                     DILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQ
                     HFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIV
                     TDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEK
                     VNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGD
                     IILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKE
                     CNKETKEHNDGKE"
     gene            complement(25437..26537)
                     /gene="dprA"
                     /locus_tag="KRO40_001422"
     CDS             complement(25437..26537)
                     /gene="dprA"
                     /locus_tag="KRO40_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HBH2092244.1"
                     /translation="MEKRDTYLWLKSIGGITTKTIEIIENEIVNIEDIFDFSEKEIYN
                     LKNISLNIRKNIVKYRGHAYLENIKELLYKKAIKYICKYDKEYPENLKNIYNAPKLLF
                     YKGDIGLVNNNFNIAIVGSRKPTAYGINCAKTISCQLSQYGVNIVSGLAIGIDAYSHI
                     GCMSGKSKTIAVLGSGVDNPLPKQNLHLSNKILENGGLLLSEYNINSTVAPYHFSNRN
                     RIISGLSDGVVVVEAAIKSGALITVDFALEHGKNVFAIPGNINSQMSRGCHKIIKEGA
                     KLIENIDDILNEYNIFNIIDKKINQKYDNISLNAKSKQIIEAIKREGNLHIDSICDYT
                     GIEIKYVNSIINELVLNELVVEMNNKTYSLNV"
     gene            complement(26556..28157)
                     /locus_tag="KRO40_001423"
     CDS             complement(26556..28157)
                     /locus_tag="KRO40_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YifB family Mg chelatase-like AAA ATPase"
                     /protein_id="HBH2092245.1"
                     /translation="MLSIINSSNLVGIDSFLVKVEVDVSNGIPSFNIVGLPGKEIKEA
                     RERVKSAILNSGYKFPSTRIVVNLSPADIKKEGAFLDLSISIGLLRELIKKDENYIRE
                     SMFIGELSLDGKIRKVRGILPIIMGAKTQNIKRIFIPIENIKESLFVDEIDIIPIKSL
                     KECVDFLNEEIKVDKVRIMSFLDDKSRKENEELEKDNSYIDCKYTKINNEESKYDEDF
                     KDVKGNYFVKRSAEIAAAGNHNMFMIGPPGSGKTMIAKRVRTILPDISVEEMIEVSKV
                     YSILGMINETKGIIDKRPFRAPHHTTTKQSLIGGGMDARPGEIALAHRGILFLDEIAE
                     FDRKILETLRQPIEDGYVNISRVKYSAKYPCRVLLVAAMNPCPCGYYMSDTECRCRSN
                     EIDRYINKISGPLLDRFDIFVEVNSIKYSDFNSLKQEESSQKIKRRVENARKIQINRF
                     KKDNIKNNSEIKAYNLFKYCKLEKEASKTAEMIFNKYNLSSRSYTKLLKMARTIADLE
                     ERDLINSQCIIEAFSFRKAYYSYFK"
     gene            complement(28188..28532)
                     /locus_tag="KRO40_001424"
     CDS             complement(28188..28532)
                     /locus_tag="KRO40_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YraN family protein"
                     /protein_id="HBH2092246.1"
                     /translation="MNNKEKGDFGEKVAVNYLLSKGAKILEKNYRLKIGEIDIIAKME
                     DEIIFVEVKSRSNIKFGYPCESVSFKKRKKIIGVASYYIIKNNLNNTPIRFDVIEVYL
                     LEKRINHIMNAF"
     gene            28716..29879
                     /locus_tag="KRO40_001425"
     CDS             28716..29879
                     /locus_tag="KRO40_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2092247.1"
                     /translation="MNREKLVAFIRYLSLFILVVSYLKNVENTLYPVITMIILFLIII
                     NNQVRFFSLSNENTFILISYFLELILIFLLCNYTKTFNSIYFVPLILDISFLIKEKYK
                     YILFSFVIISSLVISLDKNIYLALESSSILLIITVLSIYIENENLSKLYSQNLYDKLR
                     ISKDELKKVNADLETYASSIEELAILKERNRISREIHDSVGHSLSTTIIQLNAIEKLL
                     KDKPLIYDLVHELREFVTESFQDVRRAISELKPVEYENYQSLFKIKELVKSFIKLTNI
                     NVKLTISKNTWNLSRNQSITLYRLIQESLSNSSRHGKATEIRIFITFNTSNLIITISD
                     NGIGCGNIKKGNGLNSINERIYELNGKVEFDNSNNGFTIRASFPKFSGGDFFE"
     gene            29872..30519
                     /locus_tag="KRO40_001426"
     CDS             29872..30519
                     /locus_tag="KRO40_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092248.1"
                     /translation="MNKIKVLIVDDEKLIRKGLKIILSSYNDLEIVGDASNGYEALEF
                     CKMNDVDIVLMDIRMKVCDGVLGTRLIKEYNNSITLLILTTFNDDEYIKDAMKFGASG
                     YLLKDSSDEVLHEGIRSSFFGNIVLDKSVAEKIMTSEKTVKQEHLYDMYNLTEKEISI
                     IRLIANGLNNKEISQELFLSEGTIKNNITNILAKLELRDRTQLAIFAFKNKIVIE"
     gene            30648..31583
                     /locus_tag="KRO40_001427"
     CDS             30648..31583
                     /locus_tag="KRO40_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092249.1"
                     /translation="MDIVRVNNITKRFNDKLVLDNISFSVKKGEIFGLIGPNGAGKST
                     LINIITNLMLPNSGSIQINGLDLSKDYIKAKSIIGLVPQELAIIETLTSFDNLEYFGA
                     FYGLKGKLLKERIIEALEVTGLTEVKKKKVKKLSGGMQRRLNIGIALLNHPKILILDE
                     PTVGVDPQSRNHIFNFIKDISKKHETTVIYTSHYMEEVEHLCSKIFIMDEGKEIAFGN
                     NDYLKSLVSTNTKLIMEIKNINAQLIFDLKNTKGVISVLENNSLLELDIDKKLQLTDI
                     LSVIDKNNSKIMKISYEEPSLEDVFLNLTGKNLRD"
     gene            31597..32694
                     /locus_tag="KRO40_001428"
     CDS             31597..32694
                     /locus_tag="KRO40_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092250.1"
                     /translation="MKLYMSVKTMLKSLKSSFILNLIYFLALPLILSWFLGMVTESMF
                     QNPIKTESTPIVIYDKDNTRLSNDLTKYLKNDLSYILTVKKDDSKAELKLTIPKGYES
                     SLLNEKSNTLNIEKLGTRDDIAILLQDILDTYHEKFYLNNSQKISSEDFSKLFNKNSI
                     DTSIINNNVKQSSYEYFALVSLGFLVIIFIMNNILSNYISESKGLSKRLYSMPITRVQ
                     FLIYDFVGLWIYSFIFLLLYVLFFRILGITFKGNFAILLLLCALSSYFMTSISTFVTS
                     FFSKKYGTAIVYALLFLQTIFGGIFSMISDTFTKLTSLSPTYLIGELFSNYETFKTID
                     SIGDLIFTCLIISTILIALAIVKENYKWREV"
     gene            32697..33761
                     /locus_tag="KRO40_001429"
     CDS             32697..33761
                     /locus_tag="KRO40_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092251.1"
                     /translation="MIRLTIANIKRYLKNHTLLINMVMLPIILIFSLNFFINNSGNQS
                     MYFSPVAIVSDSSGKYEHKLINSSKLKENSFRLNEQDKAMNLLKNNKVSAVFVLDKNF
                     SNSIDKLQRPVVKCFKIENGGGSLWAESQIESFITKSLKLKVDKNIDDKLTKTNIIDN
                     KPDKNKGSFLVVFLICYFMYINAAHLASDLFTLKKSNVLKRLISTDNKDIKIIFSIFL
                     GLFFIQSIVYTFALLCFSIIEDFNLSLNVLMIVLANSFVSTGFVFWVARVFKNESSIS
                     LISTFYSLIGLAISISSLIPSMDKLSFMTNLSKFTPFYWTIDAIKNNGSILINIIALI
                     LIGIIFVTAGSLKLRDFAKN"
     gene            34005..34502
                     /locus_tag="KRO40_001430"
     CDS             34005..34502
                     /locus_tag="KRO40_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBH2092252.1"
                     /translation="MYKIGESVMYPKEGACSVNDIVTKKINHEMQKYYELSVIFNSNL
                     KISIPVLNADRIGIRPVMDGNDVDNFIQSINKTDGVWIFDRKERLKLYQDKFHSGDVF
                     EIVKLIKMLMIQDSSKQLCSTDKEFLNKAQKFALSELAAAQCKSYTMVLEEMKKHILN
                     SKNIN"
     gene            complement(34679..34927)
                     /locus_tag="KRO40_001431"
     CDS             complement(34679..34927)
                     /locus_tag="KRO40_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092253.1"
                     /translation="MSRKAYEEALVELEKFIDERKEIIKSAEDCIDKYIVDRTLPFDY
                     KDKCVEWQQELLDIAEAQVLEANELSVLLQEKKELEED"
     gene            complement(34993..36009)
                     /locus_tag="KRO40_001432"
     CDS             complement(34993..36009)
                     /locus_tag="KRO40_001432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH2092254.1"
                     /translation="MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSS
                     FIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMSAPIFAAPVTGTTLNMGGKINER
                     DYIEPVVAGCANSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
                     RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVE
                     DALMAVEAGVDAIVVSNHGGRVLDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDV
                     LKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSMILTGCQTIKDIDGK
                     VIYK"
     gene            complement(36067..36834)
                     /locus_tag="KRO40_001433"
     CDS             complement(36067..36834)
                     /locus_tag="KRO40_001433"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HBH2092255.1"
                     /translation="MQDKSVREIKEIIETLEVEKYMEYIELLRVDERKSVQGLAIKLA
                     KKLDNIRKEEERLETINIFENEGYDKGYLYIGGIDEAGRGPLAGPVVASVVVFKKDTK
                     IEGVNDSKKLSEAKRDELFEVIKEEALDYGIGIVNNEEIDEFNILNATYMAMKKAINC
                     LKKAPDYLLVDAATIPGIDISQNPIVKGDSKSISIAAASILAKVTRDSIMYQYDRVYP
                     EYGFKSHKGYGTKEHYEAIEKYGITPIHRKSFLKNIL"
     gene            complement(36902..39091)
                     /locus_tag="KRO40_001434"
     CDS             complement(36902..39091)
                     /locus_tag="KRO40_001434"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobalamin-dependent
                     ribonucleoside-diphosphate reductase"
                     /protein_id="HBH2092256.1"
                     /translation="MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISR
                     KIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAKHYILYRERRSEIRTKAWEFDEL
                     QKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKV
                     TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTG
                     AVSFMELYSMTTGLIGQRGRRGALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVT
                     DEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNWDYAEPGILFWDKIK
                     TYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKS
                     CVREAVVALNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDES
                     LELCDLIGKTMLNEAVKQSALIAKEYGTFSEYKYENISKSKFFIENLNEDTKEMVKKY
                     GLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYTPIVKEY
                     MDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVF
                     NIYIKAWEAGLKGVTIFRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDN
                     KDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSICLKCGYSGCN"
BASE COUNT        12538 a         6757 c         4195 g        15686 t
ORIGIN      
        1 gatttatatt aaccccacta ctttacttaa aactatatac atatttaaaa atattttatt
       61 cttacatatt gtttttatct tgattcttat tactttgtga tatattttga attttctcca
      121 atactctagg agttatagat aatatattat ccactagatt gatattacta tctaaactca
      181 ttattctagt ctctccactt tcaactacta caaatgctac tggttgtaca gatatagccc
      241 ctgcgctacc tccagcaaaa ttcgtatctg atttttcatt ttttaattca atttccctat
      301 ctttatcatc atatcctttt gagtattctc ctcctcctat accaaagcca attgtaacct
      361 ttgatatagg tacaaccact gtagtatctg tttttatagg gtctcctata atagtatttg
      421 catctataga acctttaatt gtttcaagag ttgtttccat aagactctgt atcgaacctg
      481 ttgctctcat tactatcacc ttccttattt cctttatttt tattcataat tttattaatc
      541 attattataa tattaaataa agcttttatt cttggcctta tatgtatcct tatatttcct
      601 aaaacataat cttttgtaaa atctggattt acatttaaat acattttttc tgcatcaatc
      661 atattaaata aatttccata caaagtattt atcaatacat atacagaaga tgttaagcca
      721 atatttccag ttccaaaatt aatatttgaa taaagttcat gtatttttat cttttttaat
      781 aatctataaa tgctcaaaag gtcatcagct aataatatac ttgaatctat attattcttc
      841 atcccctctt ttttatcatt atttttacta ttttcagctg gataaagttg tctatttata
      901 tttattaaat taaacatgta ttttatatta agctttaaac aaatatcttt gttttttata
      961 tcagctatta ttaagatgtt tatatgagat attaaaatca acatagttac acttataata
     1021 aaaattacag ctattattaa atacttaaaa ttaaataatt cattaagctc catgtttata
     1081 ttatcatcaa aaaattacta tttatactta attatccata tttattttaa gagaattata
     1141 attttatatt tatacaaaaa aacacaacaa cttagagcat tttaaatctt ttaaaattta
     1201 aaattacata ctaaattatt gtgattttat atttttattc atttgttgcc acttcttgat
     1261 aattttctat aggtggcaat tcttcaagac tttctatatt caacaacttt aaaaattcat
     1321 ctgttgtttt ataaattatt ggtttcccta tcttattcaa tctaccagct tctcttataa
     1381 gttcattttc aaacaaagtt tgtaatacct tatcacattt tactcctctt atatcctcta
     1441 tttctacctt tgttattggt tgtttgtagg caattatagt aagagtttct aatgtagctt
     1501 ggctcaaact tttctttttc tttggttcaa taatcttctt tatatattct gcataatctt
     1561 tatttgtaca catttggtac ttattctcta acttgattat ttgaatacct ctattttgtt
     1621 ctctgtactc ctcaataagt aaatttaaca taatctctat ttcttttgat gaaagttctt
     1681 tatttattat atagtttaat tcttttatac ttattggttc cccatatgca aacataacag
     1741 attctataat atactttata tcttctcttt tcattttaac actccgaact ttttcttatt
     1801 agaatatcat caaaaaatat atcttgtact acgactattt ctttttcttt tataagctct
     1861 aatatagata aaaaagtagc tattatttca tcattttcat atgattttat aatatttgta
     1921 aaagtaactt caatcttatc ttttataata tctcttatat ataatatttt ttcttctaca
     1981 gatattattt tcttccttac tattttatct agtttctcat cattagcatt ttctatctgt
     2041 gatgttttaa ctttaaatat gtatggaagt atatttttta ttgcttcaat tgatatatct
     2101 tctaaatcca cattgtcatc aataattatc tcttctttat ttctataaaa tctctcatta
     2161 acataagtta tattttcttt tatatcttgt gatgctacct taaactttct atattcttct
     2221 aacttttcca taagttctat tcttgggtct tcttcttcat ctttttgctt ataaagcaga
     2281 tatttagact ttatctctaa aagttttgat gccatagtta taaattcact agttatctct
     2341 aaatccattt tatctagcat tttcaaataa tttagatact gcttagttat atctattatg
     2401 gatatatcct ttatatctat tttatgcttt gttattaaat cataaagtaa atctaatggt
     2461 ccctcataga cttgtaattg tatattatac ttcatatcaa tccctcttta atctgtttat
     2521 tatattaaac aaataaatat actattttta gcaacactgt atatattggt gatagtatta
     2581 ttctatacat cccagtaaat aaagcaatta ataaaattat ataactcata ctttcaaatt
     2641 tatacaaata ttcattccat ttatatggta caaatgtaga tataactccc catccatcaa
     2701 gtggaggtat cggaagtaag ttaaaagctg caaatcccat actatataaa agcacatatc
     2761 cagctattgt atttatagca tacatatgca catacttatt gataattaca cacagtatag
     2821 cagtcaaaac attacaaaaa acgcctgcaa gtgaaactat caggtttcct atcttatagt
     2881 ttttaaagtt atttggattt actggtactg gctttgccca ccctatctta aggataaaca
     2941 tagccaaaag acctattggg tcaacatgtc ttacaggatt taatgtcatt ctaccataag
     3001 ctttagctgt atcatccccc aataagtgag ctgaataagc atggccaaac tcatgtattg
     3061 atattgccat agctatacca actaaacttg ctactatttc tcctatattc atacttaaca
     3121 ttaatgtaca tctcctaaat taaattttta atattattat aacaattaaa tagcttataa
     3181 tcaaaattat tttacattat aataatttta acttctaggc ataaaattaa aatttgcttt
     3241 ttattttata acttttatta ttatatcata ttcattgtga aaatataata attacaccta
     3301 ctgtaagtat aatattatat tgacatgaat tgacattatt gtctcttagt caatattata
     3361 caagaagtat aaaaaaatat gtgttacact ttgtataaca tgaaaggagg ttacctaagt
     3421 gagacaagaa gaacgcacag tatgctttga tagggaatta aaaattgaag catatagatt
     3481 taaaggcata atgcaaaaat tcccaaacca ttttcatgaa cattatgtaa ttggttttat
     3541 agaaaaaggt caaagatatt tatcttgtaa aaataaagag tataccacaa gtactggaga
     3601 tttgctactt tttaaccctt ttgatagtca tacttgtgaa caaatagatg ataaagtact
     3661 tgattacaga tgtattaata ttaagccaga aataatgaaa aaaaccgtct ttgaaattac
     3721 aggtaaaaat tatttaccaa aatttaatca acctgttata tttcgcagtg agctagtacc
     3781 tctactacaa gaattacact atataatcat ggaagaagaa ttggatttta aaaaggaaga
     3841 gctttttttc ttcctaattg aacaattaat tgaagaacat acagagccaa atttgcaatc
     3901 taacttggaa aatacaaata tagaaattca agcagtatgt gattatctag aaaataatta
     3961 tgctgaacat atagtacttg acgaattaag cactatagca ggtatgaata agtactctct
     4021 acttcgtaat tttacgaaat taaaaggtat tacaccatat agatacctag aaaatatacg
     4081 ggtaaacaaa gctaaaaagc ttttagaaaa aggcgtagaa cctatagatg ctgcgataca
     4141 aacaggattt gtagaccaaa gtcactttac aaactttttt aagaatttta ttggtcttac
     4201 accaaagcag tatcaaaata tatttataaa tgatgattca aacaacttta aataaggtaa
     4261 aaaggagaaa taaaaatgga aactaaaaat tcaaaatgtg tcatggtaat agacgaaaat
     4321 ttaccaatgg gaattatatc caatacagca gctataatgg gaattacact aggaaaacat
     4381 gccccagaaa ctgttggccc agatgtaatt gacaaaacag gtaatagcca cttaggaatt
     4441 attgacattc ctgtacctat tttaaaagga aacaaagaaa taataaaaga tttacgtaaa
     4501 aaattatata ctttggaatt taacgattta actgttgtag atttttcaga tgtagcacaa
     4561 agttgcaatc tttatgaaga atttacacaa aagattgcta gtgttccaga agatgagtta
     4621 cagtattttg ggatagcaat ttatgggaat aaaaagaaag tgaataaact tactggtagt
     4681 atgcctttac ttagataatt gttaaacaac cctatatatg atattaaatc aaatgatatt
     4741 ttaagataca taaacttttc tatatttcta taaaaatcat aagattataa aatacttcta
     4801 tatggtaaat aaaaataccc ctatggcaaa taattacata agggtatttt ttatgtgtat
     4861 tataatcata tctttgtgta ttataattat atttcatctg ataattattt atatcatatt
     4921 atcaattatt ctttgaagca tttgtagata gcttgcctta tttatatcct tagtatttat
     4981 caattccact tcgcctatta cttttttatc tttacatatc tttatttttc ctaaaacagt
     5041 tcccttttta attggcatct taggattttt tactatttca attttcttct caaattcttt
     5101 agaacttcct tttttaataa gagcatttaa atcttcttta gcaaccaatt taactttgtt
     5161 ttcatcagcc ttatccaatg taagtgttgc tatattatca cctttactac ataacttaac
     5221 actttcataa ttagcaaatc catagtttaa aaggctagag gcatcattaa atctttctgg
     5281 agaagtctct gctcctaaag ttgcagcaac tagatgagta ttacctctct ttgcagatgc
     5341 tgataaacag tattttgctt cttgagtaaa accagtttta acaccagttg ctccttgata
     5401 atgctttata agtttattag tatttgcaag acctactgta acttgtttct tccctactac
     5461 aaccttatcc atccatgtag ttaagtattt acttatcatt tcgtgtttta atagttctct
     5521 agacattaaa gctatatcat gagcagatgt atagtggttt gcaactggaa gtccatttgt
     5581 atttgcaaaa tgagtatcat tcatatttaa ctcttttgct ttagcattca ttctatcaac
     5641 aaatccttca acacttccag ctaagtgttc agccatagca acacaagcat catttgcaga
     5701 agcaacagct atacctttta ataatgtatc aaccttttga gtttctcctg gctctaggaa
     5761 tatttgacta ccacccatac tagatgcagt ttcacttact tgaacttcat catcaagctt
     5821 aatcttgcct gaatccaaag cttctactat aagtagcata gtcattacct tagttacact
     5881 agcaggagga agctttttat gagcatcctt ttcatataaa atttgtccac taccaacatc
     5941 catcaaaatt gctgattttg aagatatatt tagttggttg gcatcagcat tttccttatt
     6001 atttgcaaaa gaaaagctta aaggagtaag cgcaattaat atagccaaag cagtactagc
     6061 taattttttc atcgatgtca cctcttaaag tttatttaaa cttattttct cacatttaac
     6121 tttttttatt ctaaatgcct agatatacct tgacctaaat tttttttctt ttcaagcttt
     6181 ttaaagtaac cttctaaaac acctttatta gacgcatttt ctattatttc aaaagcatct
     6241 tcataattca ttccatactc tcctgctatt tccatttttg tttgttttaa agcttttata
     6301 gcattttgtc ttgaaacatc atccataaga atcctcctat cagtaaaatt tatatataag
     6361 tagtttttac taataaaaga ttgttataat tggtatttta tgtaatatat atttttttaa
     6421 aatgagtatt aaaaagacct cttgtaattc ttaagataat atcaattgga tttttgatat
     6481 tactttaaaa attacaagag gtctaatttt caaatttata gtttttttat attatacttc
     6541 cattatgata ggaagtatca ttggatttcg tttagttttt tgatataaat attcttttag
     6601 gttttcttta atattattct ttaaataagc ccattcttta atatttttct cttcacattc
     6661 atttagaaca ttcttaatta tatcctttgc tccatccatt aaatcttctg actctcttac
     6721 atatacgaat cctctggaaa ttatatctgg acctgctaag accttaccct catccttgga
     6781 aatagtaact acaactatca taagaccatc ttctgataaa tgctttctat cccttaaaac
     6841 tatattacct acatcgccta ctcctagacc atcaactaat atgtttcctg tttgtatacg
     6901 gtttgctacc ttagcagaat ttttatctaa ttctaaaaca tctcctgttt gcatgacaaa
     6961 aatattttct ttatccatac caagctgttc agctatttca gcatgtcttt ttaacattct
     7021 atattcacca tgagctggca taaaaaactt tggtctaact aatgcatgta taagttttaa
     7081 ttcttcttga caggcatgtc cagaaacgtg tatatcagct atatcactgt atactacttc
     7141 tgctcctttt tcaaataaga aattgattac tcttgatatt aatttttcat ttcctggtat
     7201 tggatgagca gatattataa ctaaatcgcc actctttatt tctacttttt tgtgctctga
     7261 aaaagccatt ctagcaagag ctgacatagg ttcaccttgt gaaccagttg ttattatcac
     7321 taattcacta tcttcatact tacatatatc atttaaatct ataagcatgt catcagaaat
     7381 atctaggtat cctaattctt ttgcaactcc aactacattg accattgagc gacctgatat
     7441 agcaactttt ctattaaact tttcagcagt atttattatt tgttgtaatc tgtgtatgtt
     7501 ggatgcaaag gtagcaacta taattcttct gccatttcct tttgcaaata attcgtcaag
     7561 acctacccca acagtctttt cagacatagt aaatcctggt ttttctgcat tagtactatc
     7621 tgccagcatt aaaagaactc cttttttgct caactcacag attctatgca tatccataac
     7681 atctccatca ataggagtca aatcaatctt aaaatctcct gtgtggtata ttataccttg
     7741 gtctgtgtgt attgcaatag agtaagcatc tggtatacta tggttatttt tcaaaaactc
     7801 tacttccata ttatcaagct ttataacttg tctaggacct ataacattta acttaacatt
     7861 attcatttta tgttctttaa gttttacttg tataagacct atactaagtc ttgccccata
     7921 tacaggtaca tttattttct ttaatatata tggaagagct cctatatggt cttcatgtcc
     7981 atgtgtaata aatataccct ttattttatc cctatttttt actaaataag ttatatctgg
     8041 tataactata tctactccta acatttcatc ctctggaaaa ctaagtccag catctataac
     8101 aattatttca tctttatact caacaacagt catatttttt ccaacttcgt taagtccacc
     8161 caaggccatt acctttatct tgttggtgtt ctttttgaac aattgcatca tctccttctg
     8221 tctatttaat tttttaacac gttctacaat cataaataat atcaaatcac gcactcgcta
     8281 ccagttattc ttattgtacc ataattcgta tcatatttta agctatattt aaaatacatt
     8341 taacgtatta ttttgacaaa cctattttat tttgatatcc tctaaatatt atatgattta
     8401 atatcggata atttaggagg atttatgcgt ggtaaaactc attgtgcaat aggaatctta
     8461 acagctatcc aaacatcttt aatatttaaa attcctatat ctttagttga tattttagtt
     8521 tcagctactt ttgctgtact acccgatttg gataaatcta attctatggt ctcaaatttc
     8581 attctaaaaa acaatgtatc caaatacata tatagaattt ttatatatgc tgttaatatt
     8641 attattttct ttatttcaat aaatataaat gataattttt atttaagcgc aataattaca
     8701 tttgttgcaa ttataattat tgaagcaaaa ctaacccaca catttctaag aaaagttttt
     8761 ctatcattaa tatttatact attagctata tgcttataca tcatagaagt tgaaatatat
     8821 tttacaattt tttgtctaat gttgtcaatt tttccctggt taaagcacag aagtttttct
     8881 catagcatat ttgcaactat aatagtatat tttttactaa aacagataga attaatcact
     8941 aatattaata atttatcttt ttatggtacg attggttatg caagtcatat gtttttagga
     9001 gatttattta caaagcaagg aataccaatt ttttatccgc taagcgaaaa gaaaatttct
     9061 ttaggttttt taactgttgg aggaccattt agtaatttca tagaaaaatc attcattttt
     9121 gtacttatag gattaattat attttcaata ttaaaactat aagcatcttg aaaactgtat
     9181 atttgcattt tgtagatggt ttataataaa aaatggaaga atagcataga atataaaagt
     9241 tctatactat tcttccatcg acattaagca atagaagttt attcttctga atcgcttact
     9301 ccattacact cgtcacatag tccataaaat ttaacatcat gatcaagtat tttaaatttg
     9361 tacaatgatt gtatctcttt ttctatattg tctaaaaggt cttctttagc ttccattatc
     9421 tttccacaat ttttacaaat aagatgatga tgattatgac agtcttcttt atgtagacta
     9481 atctcatatc ttatacatcc atcgtctaag tttagttttg atattaatcc tatttcatcc
     9541 aatagctgca ttgttctata tacagtagct aagcctattt caggacagtc aaccctaact
     9601 aaatcataga tttcctcact acttagatgt gaatggtcat gtttaagcaa tatttcaact
     9661 attgctcttc tttgtggcgt aatcttaaaa ccagtttctt ttaacttgtc ttttaataaa
     9721 tccattgtat ttgccataac atcaccctta ctattttcaa ttgataatct ttattaaata
     9781 atattgtaat tgataattca ttttttgtca agacatttaa ataaatttaa tttattctca
     9841 taatataaat atatacccat aaaagatata ttattcacca aaattcataa attttttggt
     9901 atttttaata aaaaacaaaa aaacagatat atactataaa tgcttttaca attaataagg
     9961 tttaattaaa gcaaatataa taaatatctg atttttatat acaaacttaa ttacttatct
    10021 agttaagtcc atttgattca tcttcgtcgt aatttaaacc ttcttcttcc attatagcag
    10081 tatacacagc tacaacagtt tcatactctt catcactttc caaaggtatt aagatttcac
    10141 cttcttcatc ctcatcaatt ctaaagatta aagcttcttc agcttcttca tcatctaaag
    10201 gcattaatat tgcatactct tttccttctg cttctaatgt taatattatt tcaaattggc
    10261 tttcaacgcc attttcgtct attaaattta ttatattttc ttccataatg tcattcacct
    10321 caaatttatt tttattttta ttatttatat tatatatcat aagtattcaa ttttatagtt
    10381 cttttatgaa tttattttaa aatctaaata tccttgcaaa attattactg ctgccaacat
    10441 atctataacc ttttttcttt tttgtctact aacatctgct tctaataaag acctctctgc
    10501 cgctactgta gaaagcctct catcccaaaa ctctacatca atacctgttt ctgcttttac
    10561 caattcacaa aacttgatta ctttttctcc ttgtggacct aaagttccat tcatattttt
    10621 tggtaatcct gatacaattt tatttacttg tttttctttt attattgctt ttagctcttc
    10681 aatatctttt ttcttgccaa ctctttttat tgtttttaca ccttgtgcag ttaatcccat
    10741 caaatcactc acagcaactc caatagtttt atcaccaaca tcaagaccca ttattcttcc
    10801 atctaacata gttcctcctt tatctattta tattctatag attaaataca tattctgaac
    10861 ctctcataac taaggtcaca ggcttactgc ttcatataat tttacataat caatcataaa
    10921 aattgcaata tgatttttta tgtaagcatc cagtttacat taataatcat attgcatttt
    10981 ttatttaaat cctatatgaa cagtaaaaat ttttttagtt atttttttca aatattatca
    11041 tatttatact tattattatt agtggtataa gtatatatat agatgctgta gatgcagcaa
    11101 ctattccaga atcattaact aaaagagtaa ttatacaacc aaccatagat gcaataaacc
    11161 ctttaaacaa gattggaaaa ttattcatta tctttctaaa gtgtctagat ggtttaaata
    11221 taagcactgc aattactcca attcctacaa gtaaaatatt tacccataca cttgtctgtg
    11281 ctagttgcat attcatttga atttttcttc caaatgtttg taatatctct cctggtccat
    11341 ttaggaaaat tctctgtaca aacataccta aatgagattc actacctgaa agtatatcta
    11401 aagctgcaaa tgcaaaaacg acaactacag ctgaaacagc taataataca gctttcttaa
    11461 aatctatttt aatgtcatat ataagcatta taaacaacaa atatgctaca cattctgata
    11521 tagctccacc aacatttgca cccattgaag gatatgcact agttataagt attattaatg
    11581 aaaaaattac aacaagtaat ttagatacct tcttataatg taataatact gctaagccaa
    11641 atactgcact tgctatagtt acaccttcat attcatttcc tacaccatag tacctagctc
    11701 ctatgacagc atcataactc attatgttat tttgcattaa gtatgttcca aatacagaat
    11761 ctataactat gactaaaata gtaagtgttg caaaaaatcc catgtgcttt atatcattgt
    11821 ccttaaataa ttttctacct aacaagtata atattagcgt agtcgcaaat attcccaaag
    11881 atattgaaat tggagtttta aaattcatca aaggagctaa cataaatgat agtggcatta
    11941 ttatgcctaa ttttataaac tccttaagta ctttgaatac acgctcttta tgtggcatat
    12001 aatttctaaa gaaaatcgca aacatggcaa ttacccaaga agcagatatt acgcctacaa
    12061 agccatttat aatagttgac cttattgaag atatagacac tatcctttca taaagtgatt
    12121 ttagatagct aatattgtcc tctttattta ctaaagtata acttctacct accatctctt
    12181 tattttcaag accaaatgta cctagtatat ctactccaac atctaaattg gcaacaattc
    12241 cagcctttct tgttgtggca gattccagta gacctttccc ttctccacta aattttatta
    12301 ttggagaaag tcttctctta ttcttataat ctaggtcact tggaaatgca cttgctatat
    12361 aaacagtgtc attttctcca accatagaaa atacttgttc aagatattta tttatatttt
    12421 ttacaatatt tttcttcatt gtatcataag tattatcatt tagatttaat ctatacatat
    12481 ctaatctata tgtatctcca agttctacaa atatagcatc actattttta taggattttt
    12541 tagtttcatc tagtaattta tcataatctg tagatattcc aaatggcatt ttagaatctt
    12601 tcttattaat attatcaata ttacctgaat caatccttcc atattggtcc atagctacta
    12661 aacataagtt tctgttttta actaattgat tattttcaat tatatcagca tttccaatta
    12721 cagatgtctt taaaccattt tctgataaag tttttcctaa tgaccctaaa tttgctccat
    12781 attctccata ctcaagattt tcatttatag atctattaat gcctaaatca tttatttctt
    12841 tagctttttg acctgttgcg acttcaaaag ctttagcagt atcttggtct actttttgaa
    12901 aattgatata gtcttcagta gttacactag ctcttgttcc tgcacccata cttgcataag
    12961 accttctatc atcagtacct tgatcccctc ttatattcat gagagctaca tagcctctct
    13021 tttctatctc atttttcaag attggaatat tcatcatact tccaagattg gtcctattca
    13081 tatcaataaa tatgaccttg cctttttctt cagcaaaacc atagctagca gttgatacaa
    13141 aaatcataat gactattgca aacaacgaca taatcttttt tctcatttat ttgacctact
    13201 ttctattcag atagtgcgtg attacttctt caagtatctc atctctttca aattttttaa
    13261 ttatagctct tgcattttta tgactagtta tatagctaga atcaccagaa aggagatacc
    13321 ctataatttg atttataggg ttatatcctt tttcaactaa tgctttatat acaaaatcaa
    13381 tagtatctcc tacactcatc ctatcttctg gtattccttc aaatttcata gtgtagtcta
    13441 aatctttttc caaactaaaa acctccttga gtgaatgtta tttaacttgt gtcttaataa
    13501 cctcacttgc atagcttaaa gcttggtcaa ccttagatac atcactagct cctgcttgtg
    13561 ccatattagg tcttcctcca ccttttcctc cagctatttt tgcaacttct ctaacaatat
    13621 tacctgaatg tattccctta tctaatacat ctttagtggc agtaactaca aagttaactt
    13681 tatcatctac tacatttgca agtactacta caccagaacc aagcttatct cttagattat
    13741 ctgctgtttc tcttagtgta tccatatcca taccttcaaa tttattagtt atcaaattaa
    13801 ctccatttac ttcaacttta gaatcaaaaa tagaatcaac tgattgtaaa ctcatcttag
    13861 ctttcatatc atgcaattct ttagataagt ttttattttc ttctaataaa gaacttattc
    13921 tttgaattaa attatcttct ttagatttta agtttacaca aacttcagag ataattccat
    13981 ctctttcttt taggtattca taaacagctt ttcctgttat tgcttctatt cttcttacac
    14041 ctgctgctac tccaccttca gataatattt tgaacattcc tacttgagaa gtatttgtca
    14101 agtgagttcc tccacaaagt tctgtagaat aatctcccat agaaactact cttacctcat
    14161 caccatattt ttcaccaaat agtgctgtag ctcctttttc tttagcttcc tttatattca
    14221 taatatcaca ttttatgtct aaagatgata aaataacatt atttactttt tcttctatta
    14281 cttttaattc ttcatttgat atcgcttcaa agtgagtaat atcaaatcta agtctttctg
    14341 gagttactaa agaaccagct tgattaacat gttctcctaa tacttctctt aatgccttat
    14401 gaagtaaatg tgtagcactg tgatttcttg cagctgacat tctagtttct ctatctacga
    14461 gtgtctttac tttgtcccca ttacttattc ttcctgattt tattatacct atatgtttta
    14521 tactattatt agcacctttt ttagtattta atacttctaa aactaagttt tcattagtta
    14581 tcaatccaca atctccaact tgtcctccac cttcaggata gaaagtagtg ttatctagta
    14641 ctatagatac cttatcgcct tcttctgcac tttgaactag ctcatcatct ttaactatag
    14701 cttcaatagt tccttcacca taaatttcac tatacccatt aaatgtactg tcaactgtag
    14761 attctaattt tgatagaggg tcttccttcc aactttctct atccatattt cctctagcat
    14821 ttctagctct ttctttttgc ttttccattt cttcattaaa agcttcttca tctacagata
    14881 gatgttcttc ttctaatatt tctttagtta agtctatagg gaagccataa gtatcatata
    14941 gtttaaaagc ttcttgacca cttaggacag tctttccttc attttttaat acttctatat
    15001 aagagttcaa tatttctgtt ccttggtcta tagtttcatt gaatttttct tcttctattc
    15061 caactacttt tttaatataa ctttcttttt caactaaaac tggatatgct ttatcattta
    15121 cttttataac ttcatctatt agtttctgta aaaataattc ttttactcct aataacttac
    15181 catgacgagc agcacgtcta aggagtcttc taagaacata tcctcttcct tcatttgatg
    15241 gaagcactcc atcactaact aagaatgtta cagctcttat gtggtcagtt attattctta
    15301 ttgatatatc attttttgga ttctctccat attttactcc tgttaacttc tcaactgctt
    15361 ctagtataga tttaattgta tcaacttcaa agatagtgtc tacgccttgc ataatacatc
    15421 ccattctttc aagacccata cctgtatcta tattcttgtt ttctaataga ctataatttc
    15481 cttcttcatc tctatcaaat tgagtaaata catggttcca aaattctaaa tacctatcac
    15541 aatcacagcc tggtttacag tctggattgt cacatccata ttcttctcct ctatcaaaat
    15601 atatttctga acaaggacca caaggacctg tacctatttc ccagaaatta tcatcttttc
    15661 caagtctaac cattctttct tctgggaaat tcatttcttt tgcccatata tcataagaat
    15721 catcatcttc ttcatataca gtcacccata tcttatcttc tggtatattt agccattctg
    15781 taacaaattc ccatccccat ttgattgact ctcttttaaa gtaatctcca aatgagaagt
    15841 tacccatcat ttcaaagaat gtagcatgtc ttgcagttat acctacattt tctatatctc
    15901 ctgttcttat acatttttga gatgtacaca ttctcacact tggaggtact tctacacctg
    15961 aaaagtagtt tttcaaaggt gccatacctg agtttataag taacaaactc ttatcattgt
    16021 ttggtactaa agaataacta tttgctacat aatgaccttt tgactcaaaa aattctaaaa
    16081 acttacttct tatttcattt aatcccatct tttccatatc atgttcctcc taataaattt
    16141 tattttttcg tttaaataaa aaacctcgtc cctataaata aatttatagg ggcgaggaca
    16201 atcgcggtac caccctaatt atcatacaaa gtatgatatc ttcggaaaac cttagctata
    16261 acgtaactac cgtcaatctc tacttaaatc ttctttataa aatataaatt gttcaagatt
    16321 gctactaaaa ggctgcttca aatatcatat tctaagggct tccagcattt ccctctctct
    16381 gtaagacatc aaatatttta ctattcctta tcactgtatt tgttttttaa ttaatatact
    16441 aattatatta ctaaatttta caaaattaat caatactata ttttcatata caataaattt
    16501 attttataaa ctttatttac tcttaatata ctttattgct tattttttta attttttaga
    16561 tgtttttata aacttttctc gattatacct ccacctacta caatatctcc atcatacatt
    16621 actacagatt gacctttagt aatagctctt tgagcttcat caaaaactat tttaatagta
    16681 tcttctccta ctctatgaat agtagctggt gatggttttg ctgaatatct tattttggct
    16741 tgaactctta agggttcttc taacgtatct attgatataa agttaacatc tttagcaata
    16801 agttcctttt taaataaatc ttcattgtct ccaagaacta tggtattatt tattggattt
    16861 atgtctatta caaacattgg ttttccaaaa gtaattccaa gcccttttct ttggcctata
    16921 gtataatata atataccctt atgttttcca agtatattgc ctttagtatc tacaaaaaaa
    16981 ccttcttcaa tacgcttttt agaatgtttt tttacataat ttgcatagtc attatcttta
    17041 acaaaacaaa tttcttgact atcaggctta ttgtgtactg ccatacccat ttccttagca
    17101 atttctctta ctctatcttt ttcatagtca cctattggta gtaaagtatg ctctagttgc
    17161 tcttgtgtaa gattataaag tgcataagtt tggtcttttt tatctgtaac agattttttt
    17221 agcaaatatc ttcctgtact ttcatccttt tctatctttg catagtgacc tgtagctaca
    17281 taatcacaac ctatttgtct agccttctta taaaaatcat caaattttat atgtttatta
    17341 caagctatac agggattagg agtttttcct tccaaatatt catctataaa ataatctatt
    17401 actttttctt taaacacttc tctaaaattt aaaacataaa atggtatacc tattttattt
    17461 gctacccttc tagcatcttc aacagcagat aaagaacaac aaccaccttc aatttcaaca
    17521 acatcatcat cttgccacaa cttcatagta acaccaatga catcatatcc ttgttgtttt
    17581 aaaagatatg cagctacaga gctatcaact cctccactca tacctatcat tactttttta
    17641 ttcataaaca aatttcacct catcttttgc attacttatt attataccat atagagcaag
    17701 tattgtactt atttaaaata tagcttgttc tattttctaa aaaaataatc atctttatta
    17761 tttgaatctt atggattatt ttgttaacta attaacctct aaatcaagtt aaaatactta
    17821 atttaggcaa taaaaaatag ccattttaaa aacagctatt ttttatgtcc taattatatc
    17881 attagtactt ctttttaatc attgtaaact tctcataaca caatcactta tttttattct
    17941 tcttcttcaa catcatggtc atgagcatca tctataacat atccatccaa ttctggtata
    18001 tggatattgt tcttttgagc ataatctata agagctgctt ttacagcttg ttcagctaaa
    18061 actgaacaat gcatctttac tggtggtaaa ccatccaaag cttctgcaac agctttattt
    18121 gtaagttcta atgcatcttt tatagttttt ccttttatca tttcagttgc catagaagaa
    18181 cttgctatag ctgaaccaca gccaaatgtt ttaaacttaa catcctttat tacatctcca
    18241 tctatgtcta aaaatatctt cattatatct ccacatgtag ggtttccaac ttcacctaca
    18301 ccacttgcat tatcaatttc tcccatattt cttggattca taaaatgttc cataacttta
    18361 tcactatatt gcattatctt ttcctcctac tcaatttatg tctatttttt atgctttatc
    18421 tttatgtcta ttttactaaa ccttgtttct tcgcatcatc ataaagtggt gacatgcttc
    18481 taagtctttc tattactttt ggtaagttct ctagtatata atctatatca tcatctgttg
    18541 taaaatctcc aactgtaagt cttaatgaac catgtgctat ttcatgtggt aaacctattg
    18601 caagaagtac atgtgaaggg tctaatgaac cagaagtaca tgcagaacca cttgaaccag
    18661 caattcctaa catatctaat aataaaagta ttccttcacc ttctataaat tggaatgcaa
    18721 agtttgcatt tcctggcaat ctattttcta agctaccatt tactcttgtg taaggtattc
    18781 tttctaacac accatctatt aacttatttc taagacgagt taaagtttct acatgatttt
    18841 gcatattttc cttagctaat tctgctgctt ttccatatcc aactattgca ggtatatttt
    18901 ctgtaccagc tcttttgctt ttttcttgtg ctccaccatg gacaaagtta tgaagtctta
    18961 caccttttct tatgtataaa gctcctacac cttttggtcc atatatttta tgtgaagaca
    19021 tactcatcaa atctattcct aattctttaa catctactgg aatattacct gtagcttgta
    19081 ctgcatcagt gtggaataat atcttatgtt ttttagctat ttcggatatt tctttaatag
    19141 gctgtatagt tcctatttca ttatttgcaa acattatact tataagtata gtagtatctt
    19201 ttattgaatc ttctagttgc tttaagtcta cttttccttc gctatcaaca tctaaataag
    19261 ttatttcaaa tccatgatgt tttgctaagt attcacatgt atgaagtatt gcatggtgtt
    19321 ctatttttga agttattata tgattacctt tgtttttatt agcataagct acaccctcta
    19381 gtgtccagtt atcactttct gaaccacctg ctgtaaaata tatttcacta ggttcagcat
    19441 ttataagggc tgctacttgt tctcttgctt tatccaaagc atcttttgct tctcttccga
    19501 atgtgtgaaa actagatgca ttaccaaaat aatctgttag gtatggcatc attgcatcca
    19561 atacttcttt tttaataggt gttgttgcag aataatccat atacaatctt cttttttcca
    19621 ttacattcat ctccaaatct attttttaat atttgttata tcattttcta atttattttt
    19681 gttatagtca tttatcatat ctttaagagt aattgaatct ataacatctt ctataccctt
    19741 tttcatcttt tcccaaacta tttttgttac acacatgttt gagttttcac atacatcttc
    19801 atctagtaca cagtcagata atgcaactgg tccttctaat actacaagta tatctcctac
    19861 tgttatgtct tcagcattct ttgaaagcaa ataacctcct tgagcacctc tcacactttt
    19921 tactagaccc gattttttta aagatgaaaa tatttgttct aagtactgat ctgatatttt
    19981 ttgcttctta gcaataaatt ttaatgatac tggtccattg tcttgattta atgctaattc
    20041 aaacattgct tttagtccat atctaccttt agtagacaac ttcatatatt atcacctcta
    20101 tatagaaatc taattcatac tgttttagta ggaattactt tcaagataat tttattatac
    20161 cctactaatt ttgtcaagat taattttaat tttttatttt gaataaattc cccattttcc
    20221 aatgttttca aatcctagtt ttttatatat ctttccagcc tcttcattat cataaaacaa
    20281 acaaggaatt ttgttttctc tcagtaactc tgaacatagt ttaattaggc attttgtagc
    20341 aagtccttta gctctatatt taggatgtgt tcctactcca attatcattg catgagtcct
    20401 attttctgaa gtactctttg ccattgacac cacctgtttg ttaatctcta tacaatatcc
    20461 tctacctgtc cttagtccat tttttaaatt ctctaaagtt gtactgtgaa attcatctat
    20521 taagtcataa agttttactg tcttttttag atttccaagc ctaattctct taacctttgc
    20581 attacaatta ttatctatca aaaacttttt agtttgaagt ttgcaaaaat caactacctt
    20641 taaattatta agtcctaatc tctttgctaa agcatctaca gcacatattt tcccagatat
    20701 ttcttcgtaa ttagtattac gaagtagatt ataaaaacct tcaacatcat actctccatc
    20761 agaataaaac atcataaatt caaaatattt aagtaatatt gcctttattt caccatgttc
    20821 acccacatct gcccatatat ttaaaaaatt atttccatat ccatatcttt caatatcccc
    20881 tattataaac aaattgtact caggttcttt ttttaagtat ttcataactc tactgtgata
    20941 agttgagtta agttttataa tcataatatc tacccccgat acataaagtt cagtctaaaa
    21001 atcactattt agatattcta aatatttttt tatatttttc tcagttttat tttcttgtgg
    21061 tatgtaataa atactatctt ttatgctatc tggtaaatac tgttgcttta cataatgatt
    21121 tttaaaatta tgaggatatt tgtatccaca acccctacct atttctttag aaccagaata
    21181 gtgagcatcc tttatactat ttggtatatc cttaacaaac tctttatcca gttcatccat
    21241 agctttcatt attgctatac atgcagaatt agactttgga gatgtagcca aaagaatagt
    21301 agcttctgct aatggtattt tcgcttctgg aaatccaagt tgcatagctg agtctacaca
    21361 tgcctttaca attacaatag catttggata agctaaacct atatcttcac tagctattac
    21421 taaaagtctc ctacatatac ttatcaaatc cccacctttt ataagtcttg ctagatagtg
    21481 tatagatgcc tgtgggtcac ttcctcttat agatttttga aatgcactta aaatatcata
    21541 atgactatca ccatttttgt catagtttat aattttatta aatgtagatg cccttattac
    21601 atctgaatct atataagtta tattatcctt atttggttta gttgaataga ctaccacttc
    21661 taaaatattt aaggctcttc tcatatctcc atcagaaaga attgctatat cttcaatagc
    21721 attattattg cactcaatat ccatatagct atcttcattt aatacttcaa cagctctttt
    21781 cagtcctttt tctatatcaa gtttttctaa aggtttaaat tcaaatacag tagacctact
    21841 taaaagagct ttatatacat aatgatatgg attttctgta gtgctagcaa tcaaagttat
    21901 actcccattt tccataaatt ctaatattga ttgttgctgt tttttattaa aactttgtat
    21961 ttcatctata tataatagga ctccatttac attatttata cttccaagct ctgatatcac
    22021 cttttttata tcttctaaag atgaattagt agcatttatt ttatagaagc ttttattgct
    22081 tctttctgct attatttccg ctactgtagt tttaccaaca ccaggaggac caaaaaatat
    22141 catatttggt aaaaaattag attgtaatat cttagacaat atttttccat tacctattat
    22201 atgactttga cctattacat cattcattgt ttttggtctt attttatctg ctaaaggcat
    22261 tttctcactc ctttttaata tacttatcat taccttaata attcgtctaa aaaaggtatc
    22321 tatttgaaat agataccttt tctaatctaa acctataaaa tatagattat tgattgtttt
    22381 ttaatttttt taattcatct gtaagtttgt cattaagtat tcttatatga gtacctttca
    22441 tacctaatga tcttgattct atcacacctg cactctcaaa ttttctaagt gcatttacta
    22501 ttacagacct agttatacca actctatcag ctatcttact tgctacaagt agaccttctt
    22561 ttccatccaa ttcagcaaaa atatgttcaa ctgcttcaag ctcggagtag gacagagtgc
    22621 ctattgccat ttgaactaca gctttctttc tcatttcttc ttctaattct tcacctattg
    22681 ctcttaatat ttcaagacca acaacagttg cactgtattc agctattact aaatcatcat
    22741 cattgaatga atttgaatat cttgaaagta ccaatgttcc taatctttga ccgcttccta
    22801 atattggaac tactgtagta tatttttgta atcttccatg ttcttcagga aagatttcta
    22861 atatcttctc accatttaaa ttttctaatg tttcatcaat ttttaacaca ttttgagtat
    22921 attcatctga aaatttcttt tgcttagtat actcatcttc tataactgaa ctgtcttgaa
    22981 catcatttaa atgaagacct agtactttac cttttgcact tactacataa acattagaac
    23041 ttaaaacgtc gcccaatgct ccggccagta aatcaaaaga gacactgctt ccaccacttg
    23101 tttgtaatgt tttatttatt ttccttgttt tttgtaacac ttcacttgcc atttaatcat
    23161 ctcctcatga aatttaggcc ttttaataac cttttatatt ttctaatatt attttcacat
    23221 ttaatgaaaa tttatttttc tattagttgt ttacacttga aagattatca tagattggaa
    23281 cctttttcaa gagaattatg tgattttttt caattttcac tcttttccgt cattatgctc
    23341 ttttgtctct ttattacatt ctttattaga acacactgtt tttgtttcag atttagtcac
    23401 tttttcaacc atatatgaac cacacttctc acaaaactct cctgttggct tattccaagc
    23461 tacaaagtca cagtttggat aattagaaca cccataaaaa gctttacctc ttttagattt
    23521 tctaagtata atatctcctt cttcacattt tggacattta acaccaattt tattcataat
    23581 tggtctagtt gttttacaat cgggatagtt tttacaagcc ataaactttc caaatctacc
    23641 atatttgata accatattag acccacagtt ctcgcaaatc tcatcagttt cttcatccat
    23701 atttactttt tctatatttt caagagcttc ttcaatagcc tctttaagtg gtgcatatga
    23761 ttctgataca atctttttcc agtctgtatt gccttcttct ataacatcaa gtttactttc
    23821 catatcagca gtaaaatcta catctataaa tttatggaaa ttattttcca aaatatcagt
    23881 aactattatt ccaagttctg ttggacatag acttgttcct tgcttttcaa catactctct
    23941 attcagtata gtagctattg ttggagcata cgtacttggt ctacctatac ctagttcttc
    24001 tagtgttttt actaaactag cttctgtata tcttgctggt ggttgtgtaa aatgttggtc
    24061 tggcaatata ttttctatat ttaatatatc tcctttttct atacttggta aaattttgtc
    24121 ttctctttct gaaaaattat ataccttggt ataaccatca aatttcattt ttgaaccagt
    24181 tgccttaaat acaatatcgc ctattttaca ttctacattt agtatatcaa acactgaatc
    24241 ttccatttga ctagctacaa atcttctcca aattaaattg tataacttgt actggtcttt
    24301 gctcaatgag gcttttatac tctcaggagt tctatcaact gaggttggtc ttattgcctc
    24361 atgggcatct tgaacctttt tagtatcctt tttttctttt ttatcaccag tgtttttata
    24421 gtagttttct cctaaattgt ttacgatata gcccttagct ttttcttttg cttcatcaga
    24481 tattctttta gagtcagttc ttatatatga tataagacca acagtacctt caccttctat
    24541 gtcgatacct tcatataatt cttgtgctat catcattgtt tttttagtag taaaaaataa
    24601 cttatttgct ccttcttgtt gaagcatact tgttgtaaat ggttttggag ctgatttacg
    24661 tcttgattta gattctatct tctcaacctt taaatcttta ccttccattt cttttagtat
    24721 ttgatttaca gcttcttcat tttctaattc aatcttttca tcatttttac cataaaattt
    24781 caaagttata tctttgtctt ttacggtctt agcctcaaca tctattgtcc agtattcttt
    24841 tggaataaat gcctttattt ctttttctct gtcacaaatt aactttgttg taacagattg
    24901 cactctacct gcactaagac cttttctaac cttttgccat aatataggac ttatttgata
    24961 acctaaaagt ctgtctagca ctcttcttgc ctgttgtgca tcaaccaaat ttatatcaat
    25021 atttctagga tgtttaattg cttttttaat tgcatcctta gttatctcat taaactctat
    25081 tctacaatcc tcagattcat ctaaatttag tatatgagct aaatgccatg atatagcttc
    25141 accttctcta tcagggtcag ttgctagata tacttgttta gattttttag cttctttttt
    25201 taattctttt attacatcgc cttttcctct tatatttata tattgaggtt caaaattatt
    25261 ttctatatct acacctaatt tacttttagg taaatctctg acatgaccaa ctgatgcttt
    25321 aactgtgtaa tgacttttcc ctaaaaattt ttctatagtt ttagcttttg caggcgattc
    25381 tacgatgact aatgttttgg ccataaaacc atacaccccc actacctaat cttaatttat
    25441 acatttaaac tgtacgtttt attattcatt tctactacta actcatttag tactaattca
    25501 ttgattattg aatttacata ctttatttct ataccagtat aatcacaaat actatctata
    25561 tgcaagtttc cttctctttt tatagcttca attatttgct tagacttggc atttagactt
    25621 atattatcat atttttgatt tattttttta tcaataatat taaatatgtt atattcattt
    25681 aaaatatcat ctatattttc aattaatttt gcaccttctt ttataatttt atgacaacct
    25741 ctactcattt gagaatttat attaccaggt attgcaaaaa cattttttcc atgttcaaga
    25801 gcaaaatcta ctgtgattag tgcaccactt tttattgctg cttctacaac aactactcca
    25861 tcacttaaac cactgataat tctatttcta ttagaaaaat ggtacggggc tactgtcgag
    25921 ttaatattat actctgataa taataatccc ccattttcta atattttatt tgataaatgt
    25981 aaattttgtt ttggaagagg attgtctact cctgaaccaa gtactgctat agttttagat
    26041 tttccactca tacaacctat gtgcgagtat gcatctattc ctatagctaa tccacttact
    26101 atattaactc catattggga tagttgacaa cttattgttt ttgcacaatt aattccatag
    26161 gctgtaggtt ttcttgaacc tactatagct atattaaaat tattattaac taagcctatg
    26221 tcacctttgt agaataataa ctttggagcg ttgtatatat tctttaaatt ttcaggatat
    26281 tctttatcat atttacaaat atatttaatc gcttttttgt aaagtagttc ttttatattt
    26341 tctaaataag cgtgacctct atattttact atattttttc taatattcaa gcttatattt
    26401 tttaaattat atatttcttt ttcagaaaaa tcaaatatat cttcaatatt tactatttca
    26461 ttttctatta tttcaattgt ttttgttgtt attccaccaa ttgattttaa ccataaataa
    26521 gtatctcttt tttccataaa atccacctca aaaaactatt taaaataact ataataagcc
    26581 tttctaaatg aaaaagcttc tataatacac tgtgaattta tcaagtctct ttcttctaaa
    26641 tctgctattg ttcttgccat ttttaaaagt tttgtataac ttctactgct taggttgtat
    26701 ttattaaata tcatctcagc cgtttttgaa gcttcttttt ccagtttaca atatttaaat
    26761 aaattgtaag ctttaatttc actattattt tttatattat ccttcttaaa tctatttatc
    26821 tgtatttttc tagcattttc tactcttctc tttatttttt gagagctttc ttcttgtttt
    26881 aaagaattaa aatctgaata ttttatagaa ttaacttcta caaaaatatc aaacctatct
    26941 aacaatggac ctgatatttt atttatgtat ctatcaattt cattacttct acatctacac
    27001 tctgtgtctg acatataata accacatgga catggattca tagctgcaac taacagtact
    27061 ctacaaggat attttgcact gtactttact ctggatatat ttacatatcc atcttctata
    27121 ggttgtctta aagtctcaag tatttttcta tcaaattcgg ctatctcatc taaaaataag
    27181 atacctctat gtgctaaagc aatttctcca ggtcttgcat ccattcctcc tccaattaaa
    27241 gattgctttg tagttgtatg atgaggtgct ctaaaaggtc ttttatcaat tattccttta
    27301 gtttcattta tcatacccaa tatactatag accttactta cttctatcat ttcttctaca
    27361 cttatatctg gtaaaattgt ccttactctt tttgcaatca tagtttttcc tgagcctgga
    27421 ggtccaatca taaacatatt atgatttcca gcagcagcaa tttctgcact cctctttaca
    27481 aaataatttc cttttacatc tttaaagtct tcatcatatt tactttcttc attattaatc
    27541 ttagtatatt tgcaatctat ataactatta tctttttcta attcttcgtt ctcttttctt
    27601 gacttatcat ccaaaaaaga cattatcctt actttatcga cttttatctc ttcgtttaaa
    27661 aaatcgacac attcttttaa acttttaata ggaattatat caatttcatc tacaaataga
    27721 ctttctttta tgttctcaat tggtataaaa atacgtttta tgttctgagt ttttgcaccc
    27781 ataattatgg gcaatatacc tcttactttt cttattttcc catctaatga taattctcct
    27841 ataaacatac tttctcttat gtaattttca tcttttttta ttaactctct taaaaggcct
    27901 atacttatag ataaatctaa aaaagctcct tcttttttta tatctgctgg tgataaattt
    27961 acaactattc tcgtgcttgg aaatttatat ccactattaa gaattgctga ctttactctt
    28021 tctcttgctt ctttaatttc tttgcctgga agaccaacaa tattaaaact aggtattcca
    28081 ttgcttacat ctacttcaac cttaactaaa aagctgtcga ttcctactaa gttgcttgaa
    28141 ttaataatac ttaacatatt taatcctttc caaaaacatt atctttttta aaaagcattc
    28201 attatgtgat ttattctttt ttctaataaa tatacctcta taacatcaaa tcttatggga
    28261 gtgttattta agttattttt tataatataa taacttgcaa ctccaattat cttttttctt
    28321 tttttgaagc ttacagattc acaagggtag ccaaacttta tgttagacct tgatttcacc
    28381 tccacaaata taatttcatc ttccattttt gctattatat ctatttcccc tatctttaat
    28441 ctgtaatttt tttctagtat ctttgctcct tttgatagca aataattaac tgctactttt
    28501 tctccaaaat cacctttttc tttattattc attattcact ccaatacatt aaattttcac
    28561 ttttaaatta tggtcagtat acaattttac tattcaagtt tttggattga ttttatttcc
    28621 atcaatatta ataaatactt ctattgactt tattctttta tgatattatt ctagttttca
    28681 taggaaaagt ttattttttt ggaggagtgc ctttaatgaa cagagaaaaa ttagttgctt
    28741 ttatacgata tttatcttta tttatattag ttgtaagcta tttgaaaaat gttgaaaata
    28801 cattgtatcc ggtcataact atgataatat tatttctaat tataataaat aatcaagtta
    28861 gatttttttc tttatcaaat gagaatacat ttatacttat ttcttacttt ttagaactta
    28921 tattaatttt tttactttgt aattatacaa aaacttttaa ttcgatttac tttgttcctt
    28981 taatattaga tatatcattt ttaataaagg aaaaatataa gtacatattg ttctcttttg
    29041 ttataatatc ttctcttgtt attagtttag ataaaaacat atatttggca ctggagtcaa
    29101 gctctatatt gctaattata actgtacttt ctatatatat agaaaatgag aatttatcaa
    29161 aattatacag tcaaaatctt tatgataagc ttagaatttc taaagatgaa ttaaaaaaag
    29221 ttaatgctga tttggaaact tatgcaagtt ctatagaaga attagcaatt ttaaaagaaa
    29281 gaaatcgaat atcaagagaa atacatgata gtgtaggaca ttctctttct acaacaataa
    29341 tacaattaaa tgctatagaa aaactcttaa aagacaaacc tctaatttat gacttagtac
    29401 atgaacttag agaatttgta actgaaagtt ttcaagatgt aagaagggct atatctgagt
    29461 taaaacctgt tgaatatgaa aattaccaaa gtttatttaa aatcaaagaa ttagttaaaa
    29521 gctttattaa gcttacaaat attaatgtta aattaactat ttcaaaaaat acttggaact
    29581 tatccagaaa tcaatctata actttatata gacttataca ggaatccctt tccaactcat
    29641 ctaggcatgg aaaggcaact gaaatcagaa tttttattac attcaatact tcaaatctta
    29701 taattactat tagtgataat ggtataggat gtggcaatat aaaaaaagga aatggactta
    29761 atagtatcaa tgagagaata tatgaattaa atggtaaagt tgaatttgat aattctaata
    29821 atggttttac aattagagct tcttttccta aattttcagg gggtgatttt tttgaataaa
    29881 attaaagttc ttatagtaga tgacgaaaaa ttaattagaa aaggtcttaa aattatatta
    29941 tcatcttata atgatttaga aattgtagga gatgcttcta atggatatga agctttagaa
    30001 ttttgtaaaa tgaatgatgt agacatagtt cttatggata tacgaatgaa agtatgtgat
    30061 ggggttctag gtacaaggct tataaaggaa tataataatt ctataacatt attaatttta
    30121 acaactttta atgatgatga atatataaaa gatgctatga agtttggtgc ttcaggatac
    30181 cttttaaaag atagctctga tgaagtattg catgaaggga ttcgttcttc attttttggc
    30241 aatattgtgc ttgataaaag tgtagctgaa aaaatcatga cctctgaaaa aacggttaaa
    30301 caagagcatc tttatgacat gtacaattta acagaaaaag aaatatctat aattagacta
    30361 attgcaaatg gacttaataa taaagaaata agtcaagaac tattcttatc tgaaggtaca
    30421 ataaagaata acataactaa tattttagct aaactagaac ttcgtgacag aactcaacta
    30481 gcaatctttg ctttcaaaaa taaaattgta atagaataaa tctaaaaata taaagtgact
    30541 taagtcactt tttttagtga cttatagtaa tagaattata attcacaatt ctttattata
    30601 atattatagc tttttaactt atacaaaatt attttggagg gattactatg gatatagtca
    30661 gagtaaataa tataacaaaa agatttaatg ataaattagt acttgataac atcagctttt
    30721 ctgttaaaaa aggtgagata tttggactta ttggcccaaa tggtgcaggt aaatctacac
    30781 ttataaatat aattacaaat cttatgttac caaatagtgg tagtattcaa atcaatggtt
    30841 tagatttatc aaaagattat ataaaagcaa agtctataat agggttagtt ccacaagaat
    30901 tagcaattat agaaactctt acttcttttg ataacttaga gtactttgga gctttctacg
    30961 gtttaaaggg aaaactactt aaagaaagaa tcattgaagc attagaagtt acaggtctta
    31021 ctgaagtcaa aaagaaaaag gtcaaaaaat tatctggtgg tatgcaaagg agattaaata
    31081 ttggaatagc actcttaaat catcctaaaa tattaatatt ggatgaacca actgtaggtg
    31141 tagaccccca atcaagaaat catattttca attttataaa agatatatct aaaaaacatg
    31201 aaactactgt aatatatact tcccattata tggaagaagt tgagcacctt tgttctaaaa
    31261 tttttattat ggatgaaggt aaagaaattg cttttggaaa taatgattat ttaaaatcac
    31321 tcgtatctac aaatacaaaa ttaattatgg aaataaaaaa tataaatgcc caacttatct
    31381 ttgatttaaa aaatactaaa ggtgttatat ctgttttaga aaataattca ttattagaat
    31441 tggatataga taaaaaatta caacttacag atatactctc tgtcattgac aaaaacaatt
    31501 caaaaataat gaaaatttct tatgaagaac ctagcctaga agacgtattt ttaaatctaa
    31561 caggaaaaaa tttaagggac taatggaggt gattttatga aattatacat gagtgtaaaa
    31621 actatgctaa agagtttaaa aagctccttt atacttaatt taatatattt tttagctttg
    31681 cctctgattt tatcttggtt tcttgggatg gttacagaaa gcatgtttca aaaccctata
    31741 aaaacagaat ctacccccat tgttatatat gacaaagata acacaagatt atcaaatgat
    31801 ttgacaaagt atttgaaaaa tgatttatct tatatattaa cagttaaaaa agatgattct
    31861 aaggcagaat taaagcttac tatacctaaa ggctatgaga gtagtttatt aaatgaaaaa
    31921 tcaaatactc taaacataga aaaacttgga actcgtgatg atatcgcaat attgcttcaa
    31981 gatatattag atacttacca tgaaaaattt tatttaaata attctcagaa aataagttca
    32041 gaagattttt ctaaattatt taataaaaat tctattgata cttctataat aaataacaat
    32101 gttaaacaga gctcttatga atactttgct ttagtttcac taggatttct tgtaataatt
    32161 tttataatga acaatatttt gtcaaattat ataagtgaat caaagggact ttcaaaaaga
    32221 ctttattcta tgcctataac tagagtacaa ttcttaattt atgactttgt aggtttatgg
    32281 atttattcat ttatattctt attattatat gttttattct ttagaatact tggaataaca
    32341 tttaaaggta attttgccat attgctccta ctttgtgctt tatcatctta ttttatgact
    32401 tcaatatcta cctttgtaac cagctttttt agcaaaaaat acggtacagc aatagtttat
    32461 gcattactct ttttacagac aatttttgga ggtatcttca gtatgataag tgatacattt
    32521 actaagctta caagtttatc tcctacctat ttaataggag aattgtttag taattatgaa
    32581 acatttaaaa ctatagattc aataggagat ttaattttca catgtttaat tatctctaca
    32641 atattaattg cacttgctat tgtaaaggaa aattataaat ggagggaggt ttaataatga
    32701 ttagattaac tattgcaaat ataaaaagat atctaaaaaa tcatactctt ttaattaata
    32761 tggttatgct tcctattata ctaatttttt cacttaattt ttttatcaac aactcgggaa
    32821 atcaatcaat gtatttttct ccagtagcaa ttgtatctga ctcttcagga aagtatgaac
    32881 ataagttaat aaatagttct aaattaaaag aaaattcatt tagattaaat gaacaagata
    32941 aggctatgaa tctattaaaa aataataagg tttctgctgt attcgtttta gataaaaatt
    33001 tttcaaatag tatagataaa ttacaacgac ctgtagttaa atgctttaaa attgaaaatg
    33061 gtggtggtag tctttgggca gaatcacaaa tagaatcttt tattactaaa tcgttaaaat
    33121 tgaaagtgga taaaaatata gatgataaat tgacaaagac aaatataatt gataacaaac
    33181 cagataagaa taaaggttca tttttagtag tcttcttgat atgctatttt atgtatatta
    33241 atgcggcaca tcttgcttct gatttattta cattaaaaaa atcaaatgtg ctaaaaagac
    33301 ttatctctac agataataaa gatataaaaa taattttcag tatattttta ggactatttt
    33361 ttattcaatc aattgtatac acttttgctc tattatgttt ttcaattata gaagacttta
    33421 atttgagtct gaatgtattg atgattgtac tagcaaatag ttttgtttcc actggatttg
    33481 tattttgggt agctagagta tttaaaaatg aaagttctat aagtcttata tctacatttt
    33541 attctttaat aggtctagct atatctatct ctagtctaat accatcaatg gataaattat
    33601 cctttatgac taatctttca aagttcacac cattttattg gactatagat gctattaaaa
    33661 acaatggtag tattttaata aatataatag ctctaatatt aattggaatt atatttgtaa
    33721 ctgcaggaag tcttaaacta agagattttg ctaaaaacta ataattatta aatataatta
    33781 gtatctattt ttatataatt gtaaaagaat atttcaacat attaaattat tttatcttat
    33841 atttttctct ttagtttcac acatcaccaa gtctaaactt tatattatat attaatattt
    33901 ttgacttgtc aagttattta tgttataata ttaatcatta gataattaaa gcattgtacc
    33961 taagttgcaa tatctaaaat tcaatttgga ggtataacta gcatatgtat aaaattggtg
    34021 aaagtgtaat gtatccaaaa gagggagcct gctctgtaaa tgatattgta acaaagaaaa
    34081 taaatcatga gatgcaaaaa tactatgaat taagtgtcat ttttaatagt aaccttaaaa
    34141 tttcgattcc agttctaaat gcagatagaa ttggcatacg tccagttatg gatggaaatg
    34201 atgttgataa ttttatccaa tctattaata aaacagatgg tgtatggatt tttgatagaa
    34261 aagaaagact taaactgtac caagataaat ttcattcagg agatgttttt gaaattgtaa
    34321 aattaatcaa aatgcttatg atacaagaca gttcaaaaca attgtgtagc acagataagg
    34381 agtttttaaa taaagctcaa aaatttgctt tatcagaatt agctgctgct caatgtaaat
    34441 cctatacaat ggtattagag gaaatgaaaa aacatatatt aaattcaaag aatataaatt
    34501 aaaccagttt tttaaactgg ttttattttt tatactaatc atccatgcta ctttagctta
    34561 ttttaaactg cctaatctaa tattaataaa gttatctcaa ttagatagat gtattttatt
    34621 caaataaaaa aaaactaaga gtaaatcata ttactgattt actcttagct aataaaattt
    34681 aatcttcttc aagttctttt ttctcttgta ataatacact taattcattt gcttctaaaa
    34741 cttgtgcctc tgcaatatca agtaactctt gttgccattc cacacattta tctttgtaat
    34801 caaaaggtag cgttctgtca actatgtact tatcaataca gtcctccgca cttttaatta
    34861 tttcttttct ttcatcaata aatttttcta attctactaa ggcttcttca taagcttttc
    34921 tactcatata aattccccct ttgtacaatt attctacatt aaaatgattt ttcctctttt
    34981 ttgtataaaa ttttatttgt atataacttt tccatcaata tcttttatag tttgacatcc
    35041 agttaatatc atagaactac ttagctctga ttgaagttta tttacataag tttctacacc
    35101 atcagttgca ccaccaaaag aagcagtcac aaaaggtctt cctattaata ctgcatctgc
    35161 acctaaacct atcattttta gtacgtctaa accagttctc actccaccat ctgcaagtat
    35221 tgtaacttta cctttaacag catcagcaat ttttggtaaa acttcacatg ctcctggtgt
    35281 acagtcaagc actcttcctc catgatttga tacgactatt gcatccacac ctgcttctac
    35341 tgccattaaa gcatcttcaa cagtcattat acctttcaat ataaatggta gtttagtaga
    35401 ctttactaac tcctttattt gtttaacatt tttaggaagt actggttttc catgtaatga
    35461 taaagttact agaccacagg catctatatc aactccaact gcaaatgcac cagcttcttc
    35521 agctaatctt atctttttta taatattttc attatcccaa ggtttaataa atacaattcc
    35581 agctccatta tactttttga ctacatctaa attttccatt aaaaaagcat ctactgccgt
    35641 atcaccaacc attgcataaa taccactatt agcacatcct gcaactactg gttctatgta
    35701 atctctttca ttaatttttc cacccatatt taaagtagtt cctgttactg gagctgcaaa
    35761 tataggtgca ctcattttct ttccaaacat ctctatagat gtatcaggat ttgatacatc
    35821 atgtattact ctcatattta cttttacttt ttctaaactc ttgctatttt ctataaaaga
    35881 agaaccactt cctttacctc ccatgccagg cacttcacct gcacaagcaa ccccattaca
    35941 aaccttacaa actttacaac ttccatttaa attttctcta gcacttttta ataattcatt
    36001 atattccatc tttaatcccc cattaactat agtaatttat attatataca ttatatcata
    36061 ttatatttac agtatatttt tcaaaaaact ttttctgtgg ataggagtta tgccatattt
    36121 ttcaatagct tcatagtgtt ctttagttcc atatcctttg tgagatttaa acccatattc
    36181 tgggtatact ctatcatatt ggtacattat actatcccta gtaactttag caagtatact
    36241 tgctgctgct attgatatag attttgaatc tcctttcaca attggatttt gagatatgtc
    36301 aatacctggt attgttgctg catcaactaa taaataatcc ggtgcttttt ttaaacaatt
    36361 tatagccttt ttcattgcca tatatgtagc atttaatata ttaaattcat ctatttcttc
    36421 attgtttact atacctattc cataatctag tgcttcttct tttattactt caaaaagttc
    36481 atctcttttt gcctcactca gtttcttaga gtcatttaca ccttctattt tggtatcttt
    36541 tttaaatact acaacagaag ctacaacagg tccagcaagt ggtcctcttc ccgcctcatc
    36601 aattcctcca atatataaat aacctttatc atagccttcg ttctcaaata tatttatagt
    36661 ttccaatctt tcttcttctt ttctaatatt atccagcttt tttgctagtt ttatagctag
    36721 accttgtaca gattttcttt catcaactct taacagctct atatattcca tatatttttc
    36781 tacttctaaa gtctctatta tttctttaat ctccctcaca cttttatcct gcataccatt
    36841 ccctcatctt tcgtttttaa aaatttaatt tttaaatata ttaaaatttt ttaattagag
    36901 tttaattgca tccactatag ccacatttta aacatatact acatccacct gtatgtgcaa
    36961 ttccttcact tccacactca gggcacacaa atttttcatc ttcttcaaaa tttttattta
    37021 ttatttcttt ggctttttca tctttattat ctttttcttt tttattattt ttataatatt
    37081 cttttttact attttctttt ttatcttctt tattattttc ttcctttttt tcatttatta
    37141 aaattccact ccttttacat ccatctctaa atattgttac tcctttaaga ccagcctccc
    37201 atgccttaat atatatattg aaaacatctt caactgtagt ttcaaaaggt atatttattg
    37261 tagatgatat agaagcatca atatactttt gccatacttt ttgcatgttt attctttctt
    37321 catatcctat attcatagca gtaacaaaaa aatctggtaa acattcttca tctgtaatac
    37381 ctttcttgtc catatactct ttaacaattg gagtatatac tttataatac acatcctcat
    37441 catgcaagct ttcagttttt cttatatatg aaagattaaa tataggttct attccaccac
    37501 tgatacctat cattgtagat atggaacctg taggaggtat ggttaaaagt tgtgaatttc
    37561 taagcccata ctttttaacc atttccttag tgtcttcatt tagattttct ataaaaaact
    37621 tagatttaga aatattttca tatttatact cactaaatgt tccatattct ttagcaatta
    37681 atgctgattg cttcacagct tcatttaaca tagtcttacc aattaaatca catagttcta
    37741 aagattcatc agaaccatat cttattccca tttttataag catatcagct atacccatta
    37801 cacctaaacc tatctgtcta tacttatgta cactatctct ttgttcttgt aatggatgca
    37861 agttcaatcc ctcatctaag acatcattta aagctactac agcttctcta acgcaagatt
    37921 ttaatttatt aatatcaaaa gtagcatgtt caccaaatgg ttgtattata aactctgaca
    37981 agtttattga gccaagtaga caacttcctc cacttggaag tggttcttct gcacaaggat
    38041 ttactcctga aaagcaaaag ttcttatctt cactcataaa attatatgtt tttattttat
    38101 cccaaaacaa tatacctggt tctgcataat cccagttatt tttcacaaat ttattaaata
    38161 aatcataagc atttactatc ttaactattt tttctccagt agtttcaact tcaaaagtac
    38221 aattatataa ctttttttct cttacagctt gcataaattc atctgttact cttacagaaa
    38281 tatttgcttt agtaaccttc tccaaatctg tttttatatc tataaagtcc tctatctctg
    38341 gatgatttac atccatagaa atcataagag ctcctcttct ccctctttga ccaattaagc
    38401 cagttgtcat actgtaaagt tccataaaag agactgctcc agtcgtatgt tttgcagcat
    38461 tgttaacttt cgctcctttt ggtcttagct ttgaaatatc aattccaact cctccaccat
    38521 aactaaaagt tctagcaagt ttttttgcag tatcaaatat atcttctatg ctatcttttg
    38581 gtggttctat tacataacaa ttagaatatg ttactttttt tccttctttc tgtaatcctc
    38641 tatttgctaa aattcttcca gcaaatagaa atcttttttg tcttattagt tttgatattc
    38701 ttgaactatt atttgaaatt ctctttatcc attcatcaaa actctcacca ttatgtctat
    38761 acttgttctt ccatattgat ttttgtaatt catcaaactc ccaagcttta gtccttattt
    38821 cagagcgtct ttctctatat aatatgtagt gttttgctat atcttttcta tttgattcca
    38881 taagtagtac ttcaactata tcttgtattt cttctacgga taagcatttt tccatagaat
    38941 tatagtcatt agctattttt cttgatatat catatgccaa ctctctatct actccacctt
    39001 cactatttat actagcttta tagacagcat cttcaatctt acttttacta aaaagttctt
    39061 ttgtaccatc tctttttatt atgtacttca tttttaaacc tccaataaat tagtattaaa
    39121 ttaatacaca cattaactat aactctaaac aaacttttta tatatttgta tatttt
//
LOCUS       DAEQCW010000028        38666 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.028, whole genome shotgun sequence.
ACCESSION   DAEQCW010000028 DAEQCW010000000
VERSION     DAEQCW010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 38666)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38666)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38666
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.028"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..2561)
                     /locus_tag="KRO40_001435"
     CDS             complement(<1..2561)
                     /locus_tag="KRO40_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBH2092257.1"
                     /translation="MNNDNDKNGNKIRRKKVSSSGNTNKPINRTSANKTRSTKNKKKS
                     KKSDKFKKLRVFGIVFLVLLVVGTAGTAGLVFASLRDVTPVTEAVLDKQTNQTTTIKY
                     ANGKTLSTAPSVNKKTPVPLDKISPYLQHAVIAIEDERFYEHKGVDIKGLFRSVLKTL
                     TGTKQGGSTIPMQVSKMLLTTEQQTIPRKIKDIYYAHEMSKTVSKDKILETYLNNFFV
                     GRGLAGAEAGARGYFDKSAADLTLAESALLAGSTKNPSRFSAYKTSKLEGNETKEDLE
                     NKLLFFVNTTDDDLDDPTQVDFDMIEKIKSWELISNDTYRQLKAGTLVVRKAVSNPEA
                     KKRQEIVLKKMLELKYIKQSEYDEAIKAKIEIKLPQSSDKVSSSVEDLIESEVINALM
                     EQGHTNDEAQNLFYNGGLIVNTTIDPKMQDALEEEFDRNSNFPGHMVGPDGVSQPQAA
                     MVILDYKNGEIRALAGGRNISGRKTLNRATNPHQPGSSIKPLAIYTPAIDTLKITQAT
                     ALSDSRGGYKFEENNKWNPRTTTAGHGSMSLRKALAKSSNTIAVKTAEMLGDSYDECV
                     DIMMDYLKNFGITTLKNNHSGSSEASDRKFPSLTLGGMANGITPLQMAAAYGTLANHG
                     IYVEPSIFTTITTFDGQLLVKNAPEEHKVVEPEVAYVVTDMLESVITEGTGGVAALPK
                     GMPVAGKTGTTNSAYDAWFVGYTPYYVGATYIGDDAGRKDDSGNTIKRREVPHGSTST
                     AKLWEKIMEKIHANLTVTEFEVPKNVYFTKINLEDGGKQSSGSKAAFIEGTAPTKVSS
                     QPSSEDTKKPDNNQPEENNNNNNNTGDNGGGSTPPDNGGNNGGGSTTPPDNGGNNG"
     gene            2775..3473
                     /gene="yunB"
                     /locus_tag="KRO40_001436"
     CDS             2775..3473
                     /gene="yunB"
                     /locus_tag="KRO40_001436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YunB"
                     /protein_id="HBH2092258.1"
                     /translation="MNRIVDRKTKNEFRKIIAIFLVILFLSVFIGSFIYIDKTLRPTI
                     TVLAETKALELANRSINKAVAEMVEGKINYEDLMDIQLDNNGKITMIQANTIMMNEIA
                     SAIALEIQDELKKDKTASSYIPIGTALGSPILAKYGPKLEVSIEPIGTVSVNFKTEFE
                     SSGINQTRHRIYLEAQTQVKVVIPLITSTKQIKAQIPICETIIVGDVPESYVNIPEKN
                     LGNVLPNTGKNTNK"
     gene            complement(3685..4692)
                     /locus_tag="KRO40_001437"
     CDS             complement(3685..4692)
                     /locus_tag="KRO40_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBH2092259.1"
                     /translation="MQLKNFHFKNNTLSKKTNLAKSKFTIVLTFLFLLYFFSNNLIYA
                     QNLQKNEPEYLIPIGNVLQIDAELKNIIVRNPGEASPFRLGDAIVKVNNAEVDGYSDF
                     ANTLNALPEEKQVSILLNRGGQLITMKTTKHILEKISFNNLLSGFATLTYINPDTSEF
                     GAVGHPISVGNARKIPIKTGSISTTKHLNIEKSYKGSVGCINAKRENIIGSFTENTDF
                     GIRGQINNFDISKLKKYKVASLDEVKLGKAQIILQDNFNKCKKYNIEIIDIENQKHPE
                     SKSFKIKITDKKLLAQTGGIVQGMSGTPIVQDNKIIGAVSHAIENDPAVGYGVFIKWM
                     L"
     gene            4920..5804
                     /locus_tag="KRO40_001438"
     CDS             4920..5804
                     /locus_tag="KRO40_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2092260.1"
                     /translation="MKKYRLLVTCIIAMGIIIIGTSNPVSNFYKTTNLISSGNITNEK
                     ADKDENSNKNNKDKNEDKSNSKSNKDKSSEDKSSDNKNEIQKNKKLLICIDPGHQGKG
                     DSNLEPVAPGSSSKKARVSSGTEGIATKKPEYVLNLEASLVLKSILESKGYNVIMTRE
                     THDVNISNSERAILANDKKADMVVRIHADSLNNSSKTGASILIPEKDGKYTAPIYEES
                     NKCAEFIKQNMEQSGIQINGIVQRGDLTGFNWSKVPAVLVEMGFMSNYNEDQMMSNPD
                     YQRKMMQCIADGLDAYFK"
     gene            6006..7556
                     /locus_tag="KRO40_001439"
     CDS             6006..7556
                     /locus_tag="KRO40_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH2092261.1"
                     /translation="MLVVENVSHGFGARTILENVSFRLRKGEHIALVGANGEGKSSFL
                     NIITKKLMPDAGNIKWSSRATVGYLDQHTVLSKGKTIREVLREAFKHMFDLEQEMIAM
                     YDKMGEASDDEMSKLLEETAEIQTILENSGFYMIDAKIQEVANGLGLGEIGLDKDVTD
                     LSGGQRTKVLLTKLLLENPTILILDEPTNYLDEEHITWLTKYLQEYENSFVLVSHDIE
                     FINNTCNVIYHMENGELNRYKGNYDEFVRLNDIKKRQEEQAYDKQVEERKRLEDFVAR
                     NKARVATRGMANSRQKQLDKMEILERPKEKIKPTFAFKDARAASKIIFETENLVLGYD
                     EALTKPLNFHLERGKKIALKGMNGIGKSTLLKTLLGIIKPFEGNVKLGDYLEVGYFEQ
                     ESSRENSNTPMDEVWSEFPGLTNFEVRQALAKCGLTNEHITSQMRVLSGGEAAKVRLC
                     KVMLKNINFLVLDEPTNHLDVEAKDELKKAIKEFKGTVLLVCHEPEFYSEIVDDVWNI
                     EDFTTKIV"
     gene            7585..8232
                     /locus_tag="KRO40_001440"
     CDS             7585..8232
                     /locus_tag="KRO40_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HBH2092262.1"
                     /translation="MKKFLNVLFSICISIVIIVGVINFTVGFKQLYYFDIDYLNISEL
                     SGLSKDDIKLNYDYLIDYNLNKNVSEFKLPTLKSSPQGKIHFEEVRNIFQNINKLAKL
                     LLVVSLVGIILSVKNKNIKILKTTSITLIIMPLLLTVPILLNFEKSFIIFHKLLFRND
                     YWIFNPDLDPVINILPEEFFFHSGMMILILILLVSIVLFVMYKLCKSLSIKIFQC"
     gene            complement(8374..8634)
                     /locus_tag="KRO40_001441"
     CDS             complement(8374..8634)
                     /locus_tag="KRO40_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich small domain-containing protein"
                     /protein_id="HBH2092263.1"
                     /translation="MGENYKFFNHKDCEFFPCHKTNKPEEFNCLFCYCPLYALGENCG
                     GNFKYTDKGIKDCSSCILPHKKDNYNYIMSKFQDLVKITSKK"
     gene            8851..10134
                     /gene="hflX"
                     /locus_tag="KRO40_001442"
     CDS             8851..10134
                     /gene="hflX"
                     /locus_tag="KRO40_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBH2092264.1"
                     /translation="MKEIQEKALLVGLNLTTIVKKNDDIDTNESMEELKELTKAAGAE
                     VVGSLIQNKHSVDAAYYIGKGKVEEIRAYSDSLDATLVIFNDELSGAQIRNIENVVGR
                     KVIDRTTLILDIFAQRALSKEGKLQVELAQLKYRLPRLYGMGGEMSRTGAGIGTRGPG
                     EQKLEIDKRHILNKAADIRRELKEVKKNRETQRVKRLKSNIPIVALVGYTNAGKSTLL
                     NELIKTHKDYEQEKEVFVKDMLFATLDVTLRKALLPNKKEFLVVDTVGFVSKLPHDLV
                     EAFKATLEEVQYADLILHVIDATNTSYELQKSTTEGVLKELGVNDKKHILVYNKVDKL
                     ELDIYPKSQEDIVYISAKQGINMDKLLNMIEIALMENTYSVRLMLPYERGDIFSRIKD
                     KYNVENFEYGESGITLDVDLDEEDFNIYREYILEK"
     gene            10142..10819
                     /locus_tag="KRO40_001443"
     CDS             10142..10819
                     /locus_tag="KRO40_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="HBH2092265.1"
                     /translation="MDINWENIDNLEDYFITYLLYKESKTVSQISKIRNISSTEASEQ
                     LIQAKLKIKEMQKDDFEASKDILDKFLELDKIKRLDFMDSLDDEKMVYFKRKVFKRIL
                     VEKNAEDLIVLIWATGELKDDRFLKLLHQLTNHRHSDIRRITYSAIRKIESPSSREVL
                     QKGLYDKNAQTRQYCAKALSKLGDENSLKILQQLKDKNKNFEKEYVLRAYDEAIKSLE
                     NAKNLKK"
     gene            10905..11348
                     /locus_tag="KRO40_001444"
     CDS             10905..11348
                     /locus_tag="KRO40_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH2092266.1"
                     /translation="MIVRRCAGGVVFYANKVLIVKNDRGEWTLPKGKILGGGLPYESA
                     VQRVKVETGIDAKMIDVAGDTMYEFFSRSRQQEVCNAIMWYVMEACNTDCVLAPEFQE
                     GGFYKVKDALEMLSHHKEQALVEVSYKKFKELKKLVSEGDDVPAN"
     gene            11653..12297
                     /locus_tag="KRO40_001445"
     CDS             11653..12297
                     /locus_tag="KRO40_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HBH2092267.1"
                     /translation="MSNYRTLHEFGTDEITIEKSVFIGYAKPIKSEEEALEFINEIKK
                     KHKDATHNVWAYTVGKNMNIQRYSDDGEPQGTAGIPTLEVIKKEDLRDVAVVVTRYFG
                     GTKLGAGGLVRAYTKGAKLGLEAGKIIYKVMYQEVKVKIDYTQLGKVQNELMNLGYFI
                     KDTVYEDNVEIVVYSRLEDVEKLSEKMIDITSGTGKIVLGEEFYLSEQNGEILI"
     gene            complement(12383..12760)
                     /locus_tag="KRO40_001446"
     CDS             complement(12383..12760)
                     /locus_tag="KRO40_001446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBH2092268.1"
                     /translation="MLFALIGFFAGIIGGMGMGGGTILIPALVLLAGIDTKIAQSVNL
                     LSSIPMTLIALAIHIKNKNVIFKLVIPIAVFGVLGAVFGSLLANYLSSDILKKIFGIF
                     LLLVGLFEVKKGFCAKSDKKPLN"
     gene            complement(12760..13146)
                     /locus_tag="KRO40_001447"
     CDS             complement(12760..13146)
                     /locus_tag="KRO40_001447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBH2092269.1"
                     /translation="MKKTDDLKKKYFDFNLKNTIIGVFTGFINGVFGSGGGTLLVPIL
                     NDIVKVEEHKSHATALSIIIFLTTASSVLYVSKGTYDVNLTIKVAVGSILGGIIGAKL
                     LNKVTGKFLRISFGIIMIIAALRMVF"
     gene            13325..14080
                     /gene="nadE"
                     /locus_tag="KRO40_001448"
     CDS             13325..14080
                     /gene="nadE"
                     /locus_tag="KRO40_001448"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+) synthase"
                     /protein_id="HBH2092270.1"
                     /translation="MSNIKIQIDKTVEWLINKVNEANAKGLIVGVSGGIDSAVVANLI
                     KKAFPENSMGVIMSIKSNPQDREDALKVIEGCDIEYLDLDLIEPQSAILDMVVGNLKD
                     KHLYREEYLKMTDANLRARVRMSTIYTIANNLGYLVVGTDNAAEIHTGYFTKFGDGGV
                     DILPIANLTKGEVYEWAKELGVHEDLINKAPSAGLWEGQTDEDEMGTTYNMIDAVLEG
                     RLDEVPKRDQEIIERLHRLSEHKRKTPAQPPKF"
     gene            14163..14882
                     /locus_tag="KRO40_001449"
     CDS             14163..14882
                     /locus_tag="KRO40_001449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH2092271.1"
                     /translation="MGRIGNIINRKGKQDAQRAKIFTKHARAIAVAAKEGGADPEYNA
                     ALKTAIEKAKADNMPNDNIDRAIAKGAGAGAGEDYETIVYEGYGPGGVAVIVETLTDN
                     KNRTAGNVRYYFDKNGGNLGTSGCVSFMFDKKGQILVGLGDGVSEEELMDVALEAGAE
                     DFITEEDGYEIITTPEDFSSVRDELKAKGYEFISADVKMIPQTTTVLTEESHLKMMNK
                     LVDMLEEDDDVQDIYHNWEVE"
     gene            complement(15049..16053)
                     /locus_tag="KRO40_001450"
     CDS             complement(15049..16053)
                     /locus_tag="KRO40_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBH2092272.1"
                     /translation="MATIKDIAKDCGLSSATVSYVLSGKGNERRIPLHTQELILNSAD
                     KLGYKRSTPIKHNNIKIAFYWQDEGFELASTNILQAINHIISLEHLNINIIIRPYKVG
                     HLCDDEYFFANNYYDGIVLTGINADDIEYLVKNKPKIPVVVVNREIPGFSSVSIDNEE
                     TGRIAALHAIQNGKNDIAVVFNPTSFTCMTLRGKSFLKTCKEHGIHLSDSIYYCSNKI
                     DSGYDIAQKMLAKNSLKKVIFCNHDVVALGMMNAFHESGIVIGEDIQIFAASNGPSRL
                     MARSIPPLTVIDLKMEETAERSLRMIIDTVTGRINGIQQQVIYPSIIYRQSSPAQNLL
                     "
     gene            16319..17215
                     /locus_tag="KRO40_001451"
     CDS             16319..17215
                     /locus_tag="KRO40_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="HBH2092273.1"
                     /translation="MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEI
                     SSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISL
                     SETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAK
                     CLWENGIREINLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVA
                     IESGITTVQSTLGGLGGCPFAPGASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQ
                     KSFVNGVYSGHHVNIKSDSCNC"
     gene            17352..18614
                     /locus_tag="KRO40_001452"
     CDS             17352..18614
                     /locus_tag="KRO40_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092274.1"
                     /translation="MDIIALLLFLGVIIIAFVRKNNAGILALAIGVIAVRIFGMDDKE
                     LYGAISNSMFTTLVGITLLFAIVNSTGALKLVAEKIVAASGKRVWLIPIAVFIAGFVV
                     AGVGPGAIPALAIIPAMAVPVAITVGYNPVMLALIGECGLMAGRMTPITPEGQIITTV
                     AEGVGIENVMPTILACQTLSTIVFSIVLFIIFKGYKLKKPINVIDSKQIEKFNIKQII
                     SLISIVVMIAFIIIFDMNVGLAAFAVSAVLIFFNIADEGECIKSIPWSTIVMVLGVGA
                     MMTIVDAAGGIDLMSNALSSLMNSKTATPIMSISAGLMSMVSSALAVVYPTMMPMCVD
                     IAKAVGGVDPLALIAAVGVGGSLAGVSPLSTGGALILAAMGSSKKDFNKEEQNKVFVQ
                     LFIMSAVGLLVIAVVSILSFNAITHLMN"
     gene            18690..19883
                     /locus_tag="KRO40_001453"
     CDS             18690..19883
                     /locus_tag="KRO40_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBH2092275.1"
                     /translation="MKKGALSNIKVLDLTRVLAGPYCTMMLADFGADVIKIEMPRKGD
                     DTRGFGPFVNGESLYYANINRNKKGITLNLKSEEGKNIFLEMVKHADVVVENYRPGVM
                     EKLGLGYDELAKVNNQIIYGAVSGFGCYGPYSERPGYDIIAQAMGGLMSITGQEGGEP
                     TRVGNAMGDVLGGMNLTIGILTALNARKIIGKGQRVDVSLVDSVVSSLETGIQRYFDS
                     GQPELMGNRYASAYPYDSFKASDGSFVIGCGNDKLFEKLCKKVLFREDLLIDERFKTN
                     LNRCEHYKALKPEIEKWSVKHTIKEAVDLISEAGVPAAPIYNLDCVTTDKHIAKAREM
                     IVDISHPIIGNMKVNGNPVKLMTTKAKIDMPAPSLGESNEEIYNGWLGFDSDKIKDLK
                     ENGVI"
     gene            20512..21306
                     /locus_tag="KRO40_001454"
     CDS             20512..21306
                     /locus_tag="KRO40_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBH2092276.1"
                     /translation="MESVMENLNNLKVEVKDKVCVITINRPKALNALNSDTLRELSQV
                     IDVVSENEAILGVIITGEGKVFVAGADIRQMQNYKSEEGRKYAGYAQGIFDKIEALEK
                     TVIAAVNGYALGGGCELAMSCDIRIASEKAIFGQPEVNLGVIPCFGGTQRLSRLVGTG
                     IAKELIFTGRQVNAEEAKSIGLINKVVPSDLLLEESMKMMNQIVEKAPIAIRYAKVVI
                     NKGIDMDLKNALELEKDVAGLTFATRDKQEGMNAFIEKRKPVFENK"
     gene            21401..22741
                     /locus_tag="KRO40_001455"
     CDS             21401..22741
                     /locus_tag="KRO40_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH2092277.1"
                     /translation="MNTGVIISLVGIIIALSLLVVMVMKGINIFIIAIVCSSLVAITG
                     SLNVYDALKVDYMTGFVGFLQANFFIFLTGTLMGKIMEITGGAKSIAKMIVRWIGKDK
                     ALLSIPIACGILAYGGVSVFVVSFAVFPIALEIFKEADLPRRFIPAALTFGCSTFAMV
                     APGAPQIQNIVPASTLGTDIMAGAVNGFISCAVMFIVGSTILYKMVSKEKANGGHFIA
                     HESDIFDEAEATNSKRENGPNGVIALIPLIVSILIINVKVNGKAIVPIEVGVFIGALL
                     VYLLLNKYQDNTKIVGHVGDACKTTVVAICNTCAVVAFGSVVKSAVGFDFIVNAMTNI
                     PGPPIAGAAVGTTVIAGICGSASGGLGIAAPLLGPVFLAKGVSAAALTRTMAISSAAL
                     DSLPHNGYIVTVTNGLCKETHKDAYMPIFWVTVLTPFIGTIVAVLLFTMFPGLP"
     gene            22878..24110
                     /locus_tag="KRO40_001456"
     CDS             22878..24110
                     /locus_tag="KRO40_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBH2092278.1"
                     /translation="MLNKPLEGVKVIDLTYFVAGPGTSKILADWGADVIKVEPSFGDP
                     GRKTGATMTMPIDDYNNPFYSTYNSNKRGLSINLKSETGIEIMDKLLSEANVFVSSYR
                     TGALKRLGLDYESLSKKHPHLIWGQINGFGDFGPAKDNAGFDTVAFWARSGAMLDIAE
                     KDTSPINPPIAFGDATTSCSLSGGICAALYQQAKTGKGQKVMASLFGQAIWNASSLLA
                     STQFSDEYPKTRKNAISPVINSYRCKDGKWIFLSILEHERYFEALCRLFGREDLIKEE
                     KFASSVESKKNATELINILDGEFAKFTQNEMVEKLTAADIAHEKIQHVNDVVTDEQAI
                     ANNYIYEHTSKDGNKTMLASTPVKFGNIEVNMTCDAPLIGEHSDEILRELGYSDSDIE
                     TLIESGIVTMNKEACEIC"
     gene            24150..25292
                     /locus_tag="KRO40_001457"
     CDS             24150..25292
                     /locus_tag="KRO40_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBH2092279.1"
                     /translation="MDFRLTEAQLMLQRVAKEFAENEIAPIAAETDKTGIFPRELFSK
                     MAKIGFNGIGTPVEYSGSGGADIEKVIVVTEIAKKCAASAAILSIHTIYAQAILKFGT
                     EEQKKKYLPMMAEGGCVGAFALTEPNAGSDAARAATTAIIDEETDEYVLNGTKCFISG
                     GGQAESLIIFALTDPSKGIKGMSAIIVDKGTPGFSIGKIEEKMGIHGSETAELIFDNC
                     RVPKSNLLGKEGKGFNIAMTCLDGARIGVGAQAVGIAEGALEESIKYSKERVQFGKPI
                     SALQGIQWYIADMATMVESAKLLVYYAADLKARGEKHTKEAAMAKYNASRTAREVTNL
                     ALQIHGGYGYMKDYPLERMYRDAKITEIYEGTSEIHKVVISRAVLG"
     gene            25303..26097
                     /locus_tag="KRO40_001458"
     CDS             25303..26097
                     /locus_tag="KRO40_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBH2092280.1"
                     /translation="MNIVVCLKQVPDTNEVKINKETGTLIRDGVPSIINPDDRNALEE
                     ALKMKDELGAVIKVISMGPPQAKSALKEALAMGADEAYLISDRAFGGSDTWATSTIIA
                     AAIEKVGKYDVIFCGRQAIDGDTAQVGPEVAEFLGIPQVTYAKEVKVQDDKLLVTRYT
                     ETGDYLIEAKMPVLLTAIKELNNPRYPSVKGILEAYNNGDAKITVLTLADLDVDTTQI
                     GLKGSPTNVYKSFVPVKDKHNEIIEGINKKEKAEKLIEILFDLKLV"
     gene            26108..27130
                     /locus_tag="KRO40_001459"
     CDS             26108..27130
                     /locus_tag="KRO40_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBH2092281.1"
                     /translation="MMRAKVNQGINLNDYNGVWVIGEQREGKINPVTIELIGEGRKLA
                     DQLGKELAVVIAGYEVEKEVKELLHYSVDKVYYINDPLLKDFTTDGYAISIANLIERK
                     KPEVVLVGATSIGRDIAPRIAGKVGTGLTADCTKLEIDSTDNKLLQTRPAFGGNLMAT
                     IVCPKNRPQMSTVRPGVMAKAVRNESETGILEVVTPELTEKMIRTRLVEILPQEKKSV
                     NLTDARIIVSGGRGLKRAEGFELIKELADKLGAEIGASRAAVDSGWIEHSHQVGQTGT
                     TVRPELYIACGISGAIQHLAGMSDSKYIVAINKDAKAPIFSICDYGIVGDLYEIIPEM
                     IESLNR"
     gene            27229..28605
                     /locus_tag="KRO40_001460"
     CDS             27229..28605
                     /locus_tag="KRO40_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBH2092282.1"
                     /translation="MKEQWYKDIFARVLSMTDDGFIVVNTSGVIIDINDKYCDFLGKE
                     RKDIIGQNIQSIIPNTKMLDVMKNKYCEEGAIHHYSGGNTKEKSVIVSRSYVENDNGE
                     VVAGVAQVKFRLQSFDVAKKLMSEYMELQYYKEQFKDNCGFDKLIGENRDFIELKKTG
                     VKASKTNFPVLLTGETGTGKEVFARAIHNNSSRSDKPMVSINCAAIPEELLESELFGY
                     DEGAFTGAKKGGKKGKFLVANNGTIFLDEIGDMPLTMQAKLLRVLQESEIEPVGGLKT
                     IKIDVRVISATRKNLSKMVEEGLFREDLYYRLNVINIHMMELKDRQDDILLLANYILN
                     KLNVEYKELKVLSDKVKNCFINYTWPGNIRELQNVIKSAYAVSDDMVIMMCDLPSKMD
                     NISRVAQCNVDSNCSIHEMVENYEKSLIIDVLRKYNWKCSKAAEVMGIHKSLLYKKIK
                     KYEIELNN"
     gene            complement(28937..29281)
                     /locus_tag="KRO40_001461"
     CDS             complement(28937..29281)
                     /locus_tag="KRO40_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092283.1"
                     /translation="MDQIKRLHELQQKSYLTKEEFEELKNNTYIERFELRDECDNSYI
                     YTFYTNDKCNDIKFIKSQFIVTLIKIGFLCECGGVFRQKKIVDEYDYGYNAIYKCDSC
                     GKELDKEVENYD"
     gene            29769..30779
                     /locus_tag="KRO40_001462"
     CDS             29769..30779
                     /locus_tag="KRO40_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBH2092284.1"
                     /translation="MHEDKNDIFESIDTEDFDNKTEEECLELVRKNGLNLIYIKNQTE
                     EICLEAVRQNCNAIKCVQNQTEKICIEAVKQDWRMLEFVEEPTEEICMLAINQDGTAL
                     KYIENQTEELCLRAVEKNGAALEYVKEQTEEICIEAVRNSEFGLARVKNQTEKICMEA
                     VKHCSYNLKWVENQTEEICMEAVRQNGLDLKFVKNQTETICLRAVRQNGMALEFVKEQ
                     TVGICLKAVRQYGMALKFVKEQTEEICTEAIKQDKRALSFVKGDKEKYKALYDNNEPF
                     AKRYVRNVIEKENRALIKKGEENAKIKIAGKLYDRGMSFEDISDIVEIEISKLKVSLG
                     VF"
     gene            30915..31403
                     /locus_tag="KRO40_001463"
     CDS             30915..31403
                     /locus_tag="KRO40_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2092285.1"
                     /translation="MKITVLYQTRSGNTERVAKLIEEGAKKVDGVDVKLMRLDNIDLD
                     YLNESKAVIFGTPTYLANTTWEVKKWFDEDSKKVNLAGKLGAVFATCDYICGGPDVAI
                     LTIVGHLMVKGMLVYSGGGSLGKPFIHLGHVHSIEGPELQDEKAIIFGERIATKAKEL
                     FA"
     gene            31579..33507
                     /locus_tag="KRO40_001464"
     CDS             31579..33507
                     /locus_tag="KRO40_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2092286.1"
                     /translation="MVWHIEYEIFSAIIVIFLMVYFFRSKFIPTLQNKIYCALLIFSF
                     LFIISNILGSFCLNNIDKIPIFITFLLNQIYLLLLPIPAALVSFYVMAIIYQDIRYMK
                     KRLLFLSIPLIICIILSITNPFTHILFGLSKETGYIRGCGYVATFASFFFYAIYSAFL
                     SFKYRKAMHESKIWAIRGFLIVSIVAIILQAIFLQYLLTGTACACSLLLTYLSMQNRG
                     LIIDDLTGVLNRQSFIQELDLNINTEQSGFIITIALDDFKFMNETFGTKNGDIALKEV
                     GKYLIQIHDVNHVYRIGGDIFSIVVNSQLGIEPDDIIRKIEERFKKPWLVEEISFNLA
                     TSIAVVYYPENAETTEDVIVAIDFSIHEAKRSESRRVVYADASISEKIKKKHVIKNCL
                     KEALKNDGFEVYYQPIFSNSRGRFTSAEALLRLEHKELGFIPPDEFIPIAEQTGLINS
                     IGLVVFEKVCRFIASDEFEDLKLDNIAVNLSVVQCMQKNLADDLLYLMNKYNVSPTKF
                     KLEITETVAMGSFNIIKETMERLIDLGVKFALDDFGIAYSGVTNMLSLPFSVIKLDKS
                     LIWSMNEDSRHKLTVETIIALINKLNMKAVAEGVETIKCAEDLIAMECEYLQGYYFSK
                     PVPEDVFKNLLKENTFTS"
     gene            33684..34094
                     /locus_tag="KRO40_001465"
     CDS             33684..34094
                     /locus_tag="KRO40_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HBH2092287.1"
                     /translation="MNKKKILVPIDGTERSMHSLEFIKGIFKKDEVEVEIMNVKELVF
                     IDGISLAEEIKNSENLGRRILDKAAEIMGEYDVKVHFTFGYPGDEIIRKAKEDNVDFI
                     VMTKSTKKGLTRMIGSVTASVVKQAKCIVMIVPE"
     gene            34116..34418
                     /locus_tag="KRO40_001466"
     CDS             34116..34418
                     /locus_tag="KRO40_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIBC"
                     /protein_id="HBH2092288.1"
                     /translation="MNKKIVAVCESERSLNSLKTAANDLGFDLVYEIQENDNIKNELS
                     IYDIEDASIVLFVTSDSIESIEKIDRFIDREFYEVDPKYIIEDAKSIVSEILIDLN"
     gene            complement(34635..35327)
                     /locus_tag="KRO40_001467"
     CDS             complement(34635..35327)
                     /locus_tag="KRO40_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBH2092289.1"
                     /translation="MKSLNATEKIIDYIKLNILNGTFKINSKLPSERKIADLFNISRI
                     PVRNAINILCKEGILRAVPYSSPIVEGFKKVDLFDDGEIYKNHNIQEFYVESLRARQL
                     IESEATKLAILNATSKELQKIKYTYLKSIEELDKVSHGLIEECYDADLQFHKEIILAS
                     HNPIFIKYYELIPKTVSSNQYFGFKYRNSLKDMISHHNKIMIAFDSKDSYLGYTSMYN
                     HLEDVIQLFQHD"
     gene            complement(35353..36540)
                     /locus_tag="KRO40_001468"
     CDS             complement(35353..36540)
                     /locus_tag="KRO40_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2092290.1"
                     /translation="MKKISNQKLLLLSIVTFFWFSQYVYIPFQNPYLSACNVSTNMIG
                     IIIGAYGISQCLLRLPVGVFADSINKHKIFILSGIFFAGLASLIRVFSPGGNGFLIAN
                     ILSGISSSTWISYMVHYTNFFSTEHQQKATSTIILVNNLGMLIGFVMSTLFYEKLGMT
                     ALCIMSVLSSVIGTILALNIKNHNSKKIPEKISIKKYLSICKDKRLVFFSFMALIQQG
                     IQMSTTMSFTTQILKNLGSSSTLIGLSSIFYMVCAVASSGFASTKFCTKYGPKFWIPL
                     VFILVSAYCFLVPTIKNINIIFVLQVLPGISTGILLSYLTSESMKNVPKHQKSTAMGF
                     FQAIYAIGMSVFPMIVGKISEYTSIQYGYFILAIIAILASILSYTYYKKVDLTLNYDI
                     IQS"
     gene            36876..>38666
                     /locus_tag="KRO40_001469"
     CDS             36876..>38666
                     /locus_tag="KRO40_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2092291.1"
                     /translation="MDYKNIAQEILLNVGGKENVNEVTHCMTRLRFKVKSASKVNKDK
                     LSKTEGVITVVESMGQIQVVIGNKVKKVYDEVIKIVPQSNNIGKKNESQEKQGIINSI
                     LSAVAGIFTPTIPAIAGVGMIKGILSVLAMYYMNKNGVDIKETQSYIILNAMADSIFY
                     FMPIILGYTAAKVFNANKIISMVLGATLCYPTFTALMAGEESVRFLGLAVTKATYTSS
                     VIPIIIAIWALSYVEKVLEKYIPEVIKIIMVPTLSLVVMLPATLFLFGPIGIYIGNVI
                     NFSYKYIYELSPALCGAFVGGLWCVLVIFGAHRALLPIGISDVAQTGRQNLLAFAGAA
                     NFSQAGAALGVFFKTKNQGLKTISMSATITALFGITEPAIYGANLRLKKPMVCAVICG
                     AFGGAIMGMGGAYGNAFANQGVLTIPVYAEAGALGFLSYLGGCAIAFFGSAISTYLVG
                     FEDLEESSNKENSSIKVETKDGVIDITSPVEGECIELSEVKDDVFASKAMGEGIAVLP
                     TKGVITAPTDCEVASLFPTLHAIGLKLDNGAEMLIHVGINTVELNGKYFTKHVNQGDL
                     VKKGDKLISFDIDKIKKAGYDVTTPVIVNNT"
BASE COUNT        14445 a         4618 c         6971 g        12632 t
ORIGIN      
        1 ccattatttc cgccattatc aggaggagta gtagagccac caccattgtt tccgccatta
       61 tcaggaggtg tagaaccgcc accattatca cctgtgttat tattgttatt attattttct
      121 tctggttggt tattgtctgg tttttttgta tcttcagatg atggttgaga acttacttta
      181 gtaggagcag taccttcaat aaatgctgct ttagagccag aagattgctt tcctccatcc
      241 tctaaattaa tttttgtaaa atatacattt ttaggaactt caaattcagt aaccgttaaa
      301 ttagcatgta ttttttccat aattttttcc catagttttg cagtactagt acttccatgt
      361 ggtacttctc tacgttttat agtgttacca gaatcatctt ttctaccagc atcatctcca
      421 atataagttg caccaacata ataaggagtg taaccgacaa accaagcatc atatgcacta
      481 tttgtagtac ctgttttacc tgctacaggc attccctttg gaagtgcagc aacaccacca
      541 gtaccttcag taattacact ttctaacata tctgtaacga cataagctac ttcaggttct
      601 acaactttat gttcctcagg agcattttta actaataatt gaccatcaaa ggtagttata
      661 gtagtaaaaa tagaaggttc tacataaata ccgtgatttg ccaatgtacc ataagcagca
      721 gccatttgaa gtggagtaat accattcgcc ataccaccta gtgtcaatga tgggaatttt
      781 ctatcacttg cttcagatga acctgagtga ttattcttta aagttgttat accaaagttc
      841 tttaagtaat ccatcattat atctacacat tcatcataag agtctccaag catttcagca
      901 gttttgacag ctatcgtgtt tgaagattta gcaagtgctt tacgtaaact catagaacca
      961 tgaccagcag tagtagttct tggattccat ttattatttt cttcaaactt atatcctcct
     1021 cgagaatcac ttagagcagt tgcttgtgtt atttttagag tatcaatagc tggcgtatat
     1081 attgctaaag gttttataga agaacctggc tgatgagggt tagtagcacg atttaaagtt
     1141 tttctaccac ttatatttct tcctccagct agtgctctta tttcaccatt tttataatct
     1201 aagattacca ttgcagcttg cggttggcta actccatcag gaccgaccat atgtcctggg
     1261 aaattgctat ttctatcaaa ttcttcttct aaagcatctt gcattttagg gtctatagtt
     1321 gtgtttacaa ttagaccacc attgtagaat aagttttgag cttcatcatt tgtatgtcct
     1381 tgttccatta aagcatttat aacttcactt tcgataaggt cttctacaga tgaagaaact
     1441 ttatctgatg attgaggcaa ttttatttct attttagctt tgattgcttc atcatattca
     1501 ctttgtttta tatatttcaa ttctaacatt ttctttaaaa caatttcttg tcttttttta
     1561 gcttcaggat tacttacagc ctttctaaca actaatgtac ctgcttttaa ttgtctataa
     1621 gtatcattag atataagctc ccaagatttt attttttcaa tcatatcaaa gtccacttga
     1681 gtagggtcat ctaaatcatc atcagttgtg ttaacaaaaa ataataattt attctctaaa
     1741 tcctccttag tttcatttcc ctctaactta gaagttttat aggctgaaaa tcttgatgga
     1801 tttttagttg aaccagcaag aagtgctgac tctgctagag taaggtcagc tgcagactta
     1861 tcaaaataac cacgtgcacc agcctcagca cctgctagac ctctaccaac gaagaagtta
     1921 tttaaataag tttctagtat tttatcttta cttactgttt tactcatctc atgtgcatag
     1981 taaatatcct ttattttacg aggtatagtt tgctgttcag ttgttaacag cattttggat
     2041 acctgcatag gaatagtact accaccttgc ttagtacctg taagggtctt taatactgac
     2101 ctaaataaac ctttaatatc gacaccctta tgctcataaa aacgctcatc ttctattgca
     2161 attacagcat gttgaagata aggggaaatc ttatctaatg gaacgggtgt ctttttattt
     2221 acacttggag ctgtagataa tgtttttcca ttagcgtatt taatagtagt tgtttggttc
     2281 gtctgtttat ctaaaacagc ttctgtaact ggagttacat ctcttagtga cgcaaatact
     2341 agaccagcag tacctgctgt accaacaact agtaaaacta aaaatactat cccaaatact
     2401 cttagttttt taaatttatc gcttttttta gattttttct tgttttttgt tgaacgagtc
     2461 ttgttagctg aagttctatt aattggttta tttgtattac cagatgagct aacttttttt
     2521 ctcctgattt tatttccatt tttatcatta tcgttattca taagatttta acctccttac
     2581 ttaatgcaat attataacac aaataggagt agttttgtaa ttaatagaaa aaatgaattt
     2641 gctataatat tctgtacatt gtatatgtat aaacgtaata tattaaaaag tctatatttt
     2701 tattttattt atttttgaca aatattataa aaattatgcc aaagctacat ataaataaat
     2761 aggaggggat aattttgaat agaatagtag atagaaaaac aaaaaatgaa tttagaaaaa
     2821 tcatagctat ttttttagta attcttttct tgtctgtatt tataggcagt tttatatata
     2881 tagataaaac tttaagaccg acaataacag ttttagcaga gactaaagct cttgaactag
     2941 caaataggtc gataaataaa gctgttgctg agatggtaga aggaaaaata aattatgaag
     3001 atttaatgga tatacaactt gataataatg gtaaaataac tatgatacaa gcaaacacta
     3061 taatgatgaa tgaaattgca tctgcaatag ctttagaaat acaagatgaa ttaaaaaagg
     3121 ataaaacagc aagttcttac atacctatag gaacagcatt aggaagtcct atattagcta
     3181 aatacggtcc taaacttgaa gtatctattg aacctatagg aacagtatca gtaaacttta
     3241 aaacggaatt tgagtcttca ggtataaatc aaactagaca tagaatatat ttagaagctc
     3301 aaacacaagt taaagtagta ataccactta taacttcaac aaaacaaatt aaagctcaaa
     3361 tacctatttg tgaaactata atagtaggtg atgttccaga aagttatgta aatattccag
     3421 aaaaaaatct aggaaatgtt ttacctaaca ctggaaagaa taccaacaag taatataaag
     3481 ttgtatattt ttaaataaat tcaaaataat agtttataaa taaaattttt ggaaataata
     3541 ttaatataat tttaataaaa atttatattt tatactatgt aaaatatcta atatatttgg
     3601 tctgtaggtt aaataaaagt acctttagac caaatatatt attaataact taataacatc
     3661 ttaaaactta tttatttata ttatttacaa catccattta ataaatacac cataacctac
     3721 agctgggtcg ttttcaattg catgtgacac tgctccgatt attttattat cttgaactat
     3781 tggagtacca ctcatacctt gtacaatacc accagtttga gctaaaagct ttttatctgt
     3841 aattttaatt ttaaaacttt tactttctgg atgtttttgg ttttctatat ctataatttc
     3901 aatattatat tttttacact tattaaagtt atcttgtaaa attatttgag cttttcctaa
     3961 tttaacttca tctaaagatg ctactttata tttttttaac ttggaaatat caaagttatt
     4021 aatttgacct cttattccaa aatcagtatt ttctgtaaag ctaccaataa tattttctcg
     4081 ttttgcattt atacatccaa cactaccttt ataagatttt tctatattaa ggtgcttagt
     4141 tgtagaaatt gaacctgttt taataggtat ttttcttgca ttacccacac ttattggatg
     4201 acctacagct ccaaactctg atgtatctgg attgatatac gttaaagtag caaatccaga
     4261 aagtaaattg ttaaaactaa ttttttctaa tatgtgtttg gtagttttca ttgttataag
     4321 ttgtccacct ctatttaata aaatagatac ttgtttttct tctggtaaag catttaaggt
     4381 attggcaaag tcactatatc catcaacttc agcattattt acctttacta tagcatcacc
     4441 caatctaaat ggagatgctt ctccaggatt tctaactatg atatttttta attctgcgtc
     4501 aatttgaagt acgtttccaa ttggtattaa atattcaggt tcattttttt gtaaattttg
     4561 tgcataaatt aaattatttg agaaaaaata taataaaaat aaaaatgtta aaacaattgt
     4621 aaattttgac ttagctaagt tggttttttt acttaaagta ttatttttaa aatgaaaatt
     4681 tttaagttgc ataaaacacc tctttcttat taaattattt taataataga attgaagttt
     4741 tcttgctgct tctatattat gttgtgcaag aatcatgttt tgatgcttgg aaaactagct
     4801 caataacacc ttagttttca taaaaataaa taaaataaat agtgtatatg ataaaataaa
     4861 tacatattca tataaataaa aataaacaat aactgtctag cataagaaag gagcaaaaaa
     4921 tgaaaaaata tagattgtta gttacttgta taattgccat gggaatcata attataggaa
     4981 catcaaatcc agttagcaat ttttacaaga ctacaaattt gattagttca ggaaatatca
     5041 caaatgaaaa agcagataaa gatgaaaatt caaacaaaaa taataaagat aaaaatgaag
     5101 acaaatctaa ttctaaaagt aataaagata agtcatcaga ggacaaatcg tcagataata
     5161 aaaatgaaat tcaaaaaaat aaaaaacttt taatttgtat agacccaggg catcaaggaa
     5221 aaggagatag caatttagaa ccagtagctc caggttcttc ctctaaaaaa gcgagagtat
     5281 cttcaggaac agagggtatt gctacaaaaa aaccagaata tgttttaaac ttagaagcat
     5341 ctcttgtttt aaagagtata ttagaatcta aaggttataa tgtaataatg actagagaga
     5401 cacatgatgt aaatataagt aattcagaaa gagcaatact tgctaatgat aaaaaagcag
     5461 atatggttgt aagaatacat gcagatagtt taaataattc ttcaaaaact ggagcatcta
     5521 tattgattcc tgaaaaagat ggaaaatata cagctcctat atatgaagaa agtaataaat
     5581 gtgctgaatt tatcaaacag aatatggaac aatcaggtat acaaatcaat ggaatcgttc
     5641 aaagaggcga tttgactgga ttcaactggt caaaagtacc agctgtatta gtagaaatgg
     5701 gatttatgag taactataat gaagaccaaa tgatgtcaaa tccagactac caaagaaaaa
     5761 tgatgcagtg tatagctgat ggattggatg cgtattttaa ataagatatg aatagagaaa
     5821 aagttaggtt ggtattattt tcctaatttt tatctctatt ttttattgta cataacacaa
     5881 agaagaagtt tattttaggt taaattgtcg taaatataac taaaaatatt gggaatactt
     5941 gatttaagtt taaaaagaat atattatagt atagaatgtg taaaattttt ttgagaggtg
     6001 ttgaaatgct agtagtagaa aatgtgagtc atggatttgg tgcgagaaca atattagaaa
     6061 atgtatcctt tagacttaga aaaggtgaac atattgcact agttggtgct aatggagaag
     6121 gaaaatcgag ttttttaaat ataataacaa agaagcttat gccagatgct ggaaatataa
     6181 aatggtcttc aagagctaca gtaggttact tagaccaaca tacggtatta agcaagggaa
     6241 aaactataag agaagtgctt agagaggctt ttaagcatat gtttgactta gagcaagaaa
     6301 tgattgctat gtatgacaaa atgggagaag ctagtgatga tgaaatgagt aagcttcttg
     6361 aagaaacagc agagatacaa actatacttg aaaatagtgg tttttatatg atagatgcaa
     6421 agatacaaga agttgcaaat ggtcttggtc ttggagaaat tggtcttgat aaagatgtaa
     6481 ctgacttaag tggagggcaa agaacaaaag tacttcttac taaacttcta cttgaaaatc
     6541 caactattct tatattggat gagcctacaa actatttaga cgaagagcat ataacatggc
     6601 ttactaagta ccttcaagag tatgagaata gttttgtctt agtttctcat gatattgaat
     6661 ttataaataa tacatgtaat gtaatatatc atatggaaaa tggagagtta aatagatata
     6721 aaggaaatta tgatgaattt gtaagactta atgatataaa gaaacgtcaa gaagaacaag
     6781 cttatgataa acaagttgaa gaaagaaaaa gactagagga ttttgtagct agaaataaag
     6841 ctagagtagc aactagagga atggctaaca gtagacaaaa gcaacttgat aagatggaaa
     6901 tattagaaag accaaaagaa aaaataaaac ctacttttgc ttttaaagat gctagagcag
     6961 ctagtaaaat aatttttgaa acagaaaatt tagttttagg gtatgatgaa gcattgacaa
     7021 aaccacttaa tttccattta gaaagaggaa aaaagattgc cttaaaagga atgaatggta
     7081 ttggaaaatc taccctatta aaaactttac ttggaataat aaaaccattt gaaggaaatg
     7141 ttaaattagg tgactatttg gaagttggat attttgaaca agagagttca agagaaaata
     7201 gtaatacacc tatggatgaa gtttggagtg aatttccagg gcttacaaac tttgaagtta
     7261 gacaggctct tgcaaaatgt ggacttacaa atgaacatat aacgagtcaa atgagagtat
     7321 taagtggtgg agaagctgct aaggttagac tttgcaaagt aatgttaaaa aatataaatt
     7381 tcttagtatt agatgagcct acaaatcatt tagatgttga ggcaaaagat gaattgaaga
     7441 aggctatcaa agagtttaag ggaacagttc ttttagtatg tcatgagcca gaattttatt
     7501 cagaaattgt tgatgatgta tggaatatag aagattttac aactaaaatc gtgtagtgat
     7561 ttaacttatt gctgggggga tttcatgaaa aagtttctaa atgtactttt ttcaatttgt
     7621 attagtattg ttataatagt aggtgttatt aattttactg ttggatttaa acaactttat
     7681 tattttgaca ttgattactt aaatatatca gagttatctg gtttatctaa agatgatata
     7741 aaattgaact acgattatct aattgattat aacttaaata agaatgtgtc tgagttcaaa
     7801 ttaccaacat taaaatcttc tccacaaggg aagatacatt ttgaagaagt caggaatata
     7861 tttcaaaata taaataaatt agctaaatta ttattggtag tttctttagt aggaattata
     7921 ttgagtgtaa aaaataaaaa tataaaaatc ttaaaaacta catcaataac acttataatt
     7981 atgccattat tattaacagt tccaatttta ttaaattttg aaaagtcatt tattattttt
     8041 cataaattat tatttagaaa tgattattgg atatttaatc ccgatttaga cccagttata
     8101 aatatattgc cagaggaatt tttttttcac tctggaatga tgattttaat attaattttg
     8161 ttagtaagta tagtactgtt tgtaatgtat aaattatgta aatctttatc aataaaaata
     8221 tttcaatgtt aaatagaggg atatttttat ttccaaaata agataataaa aaaggattag
     8281 attaaaagtt atacaataaa aatagctgtg caataatatt tagactatga aagtagttga
     8341 aaaatattta tgcacagcta tttataatag aatttacttt ttactagtga ttttaactaa
     8401 atcttgaaat ttactcataa tgtaattgta attatctttt ttatgaggta atatacaact
     8461 actgcaatct ttgatacctt tatctgtata cttaaagttt ccaccacagt tttctcctaa
     8521 agcatacaaa ggacaatagc aaaatagaca gttaaactct tctggtttat tagttttatg
     8581 acaagggaaa aattcgcaat ctttgtgatt aaaaaactta taattttcgc ccatattttc
     8641 ctcctaatta aataaaattt aaatttttta tactatataa gattttggtg ataatataat
     8701 tatactaaat aattttatga atagtcgata atatagtatt attaatcata gtattaatgg
     8761 tataattagt caacagaaaa ataatgtaaa aataatgtaa gtgtattttg taattagaat
     8821 atgttttata acaaaaaatg aggtgattaa gtgaaagaaa ttcaagaaaa agcacttctt
     8881 gtaggtctga atttgactac aatagtgaaa aaaaatgatg atatagacac taatgaatct
     8941 atggaagaat taaaagaact aacaaaagct gctggggcag aagttgtagg tagcttaatt
     9001 caaaataaac actctgtaga tgcagcttat tatataggaa aaggtaaagt agaagaaata
     9061 agagcctata gtgactcttt agatgctact ttagtaattt ttaatgatga attatctggt
     9121 gctcaaatca gaaatataga gaatgttgtt ggaagaaaag taatagatag aactacttta
     9181 attttagata tatttgctca aagggcactt agcaaagaag gtaaattaca agttgaatta
     9241 gcacaattaa agtatagatt gccacgactt tatggaatgg gtggtgagat gagtagaaca
     9301 ggtgcaggga ttggtactag aggtcctgga gaacaaaaac tagaaataga taagagacat
     9361 atacttaata aagcagcaga tataagacgt gaacttaaag aagtaaaaaa gaatagagag
     9421 acacagagag ttaagcgttt aaagtcaaat ataccgattg tagcacttgt tgggtataca
     9481 aatgcaggaa aatctaccct gttgaacgaa ttaataaaga cacacaagga ttatgaacaa
     9541 gaaaaagaag tttttgtaaa agatatgctt tttgcaactt tagatgtaac tttgagaaag
     9601 gctcttttgc cgaataaaaa agaattttta gtagtagata ctgttggatt tgtaagtaaa
     9661 cttccccatg atttagtaga agcgtttaag gcaacattgg aagaagtaca gtatgcagat
     9721 ttaatcttac atgtaattga tgcaacaaat actagttatg aattgcaaaa aagtacgact
     9781 gaaggtgtat taaaagaact tggtgtaaat gataaaaaac atatacttgt atataataaa
     9841 gtggacaagc tagaattgga tatatatcct aaaagtcaag aagatattgt gtatatttct
     9901 gcaaaacaag gcataaatat ggataagtta ttaaatatga tagaaattgc tttaatggaa
     9961 aatacctatt cagtaaggtt gatgttacct tatgagagag gtgatatatt tagtagaata
    10021 aaagataaat ataatgtgga gaattttgag tatggggaaa gtggtataac gctagatgta
    10081 gatttagatg aagaagattt taatatctat agagagtaca tactagaaaa ataggttgaa
    10141 tatggatata aactgggaaa atatagataa tcttgaagat tattttataa cctatcttct
    10201 ttataaagaa tctaaaacag tatctcaaat tagtaaaatt agaaatattt caagtactga
    10261 agcaagtgag caacttatac aagcaaagtt aaaaataaag gaaatgcaaa aagatgattt
    10321 tgaggcatct aaggatattt tggataaatt tctagaacta gataaaatta agagacttga
    10381 ttttatggat agcttagatg acgaaaaaat ggtatacttt aagagaaagg ttttcaaaag
    10441 aatccttgta gaaaaaaatg ctgaagattt aattgtttta atttgggcga caggtgagct
    10501 aaaagatgat aggtttttga aattgcttca tcagctcaca aaccacagac actcagatat
    10561 tagaagaata acttattcag caatcagaaa gattgaatca ccaagtagta gagaagtact
    10621 gcaaaaaggt ctctacgaca aaaatgcaca gactaggcag tactgtgcaa aagctctttc
    10681 aaaattggga gatgaaaaca gtttaaagat tttacagcag ttgaaagaca agaataagaa
    10741 ttttgaaaaa gaatatgtgc ttagagctta tgacgaagcc attaagtcat tggaaaatgc
    10801 aaaaaatttg aaaaagtaat tttttattaa agcaatttgt ttacttaatg atgtatttct
    10861 aaagtttaac aaggtaataa ataaattaat gggaggggtt tcaaatgata gtaagacgtt
    10921 gtgcaggtgg agtagtgttt tatgctaata aagtacttat tgtaaaaaat gataggggtg
    10981 aatggacact tccaaaagga aagatactag gagggggact tccatatgag agtgctgttc
    11041 aaagagttaa agtagaaact ggcatagatg ctaaaatgat agatgtggct ggcgatacta
    11101 tgtatgaatt tttctcaaga agtagacaac aagaagtttg taatgcaata atgtggtatg
    11161 ttatggaagc ttgtaacact gattgtgtac ttgctcctga atttcaagaa ggtggatttt
    11221 ataaagtaaa ggatgcttta gaaatgttat cacatcataa agagcaagct ttagtagaag
    11281 tatcttataa aaagtttaag gaattaaaga aattagtttc agagggcgat gatgttccag
    11341 caaattaatt gtgaatttag aggattctga ggaagggata gccccttcct tttttaattg
    11401 aagcagtttt aagcgtaaat tatatagtct ctttaaacta tgatttatca atttagagat
    11461 ttagtagttt atatttaaaa tcagtaagat atgtttaaaa taaaaattaa aaagtataca
    11521 attttattat ataattgtct tatgatgttg attaaagaat tattaaaagt ccatttattt
    11581 ttaaatagaa taattttata aatatatatt tgatgtgtat attagaaaat gattaaaata
    11641 ggaggaaata caatgagcaa ttacaggaca ttacatgaat ttggaacgga tgaaataacg
    11701 attgaaaagt ctgtttttat tggatatgct aagcctataa agagtgaaga agaagcatta
    11761 gagtttataa atgaaataaa gaaaaagcat aaagatgcaa ctcacaatgt gtgggcttat
    11821 actgtaggta aaaatatgaa tatacaaaga tatagtgatg atggagaacc acaaggaaca
    11881 gctgggatac ctacattaga ggttataaaa aaagaagatt tgagagatgt agcggttgtt
    11941 gttactaggt attttggagg aacaaaatta ggtgcaggtg gtctagttag agcttataca
    12001 aaaggtgcta aactgggact tgaagcaggt aagataattt ataaggtaat gtatcaagaa
    12061 gttaaggtta agatagatta tactcaactt ggaaaagtgc aaaatgagtt aatgaatttg
    12121 gggtatttta taaaagatac tgtatatgag gataatgttg aaatagtagt atattcaaga
    12181 ttagaagatg tagagaaatt atcagaaaaa atgattgata taacaagtgg aacaggaaaa
    12241 atagttttag gagaggaatt ttatttgtct gaacaaaatg gagaaatttt aatataatct
    12301 aaaaggttat tagaatagtt aatacctcaa atagccaatt agtattttta agtgaaaagc
    12361 cattaaattg atttaatcta aatcaattta atggcttttt atcggatttt gcacagaatc
    12421 ctttttttac ttcaaataaa ccgactaaaa gtaaaaatat cccaaatatt ttttttaata
    12481 tatctgaaga cagataatta gctaatagtg aaccaaatac agctcctaaa accccaaaca
    12541 cagctatagg tataaccaat ttaaaaatta catttttatt ttttatatgt atagcaagtg
    12601 ctataagtgt catagggata gatgaaagta aatttacgct ttgtgctatt ttagtgtcta
    12661 tgccagcaag taaaacgagt gcaggtataa ggattgttcc tccacccatt cccattcctc
    12721 caataattcc tgcaaaaaat ccaattagag caaataacat taaaacacca tccttaatgc
    12781 tgcaattatc ataattattc caaaagaaat tctaagaaac tttccagtaa ccttatttag
    12841 taatttagct cctataatac caccaagaat acttccaact gcaactttaa ttgttaagtt
    12901 aacatcataa gtacctttag atacatataa aacagaactt gctgtcgtta agaatattat
    12961 tatagaaaga gcagttgcat gagatttatg ttcttctacc ttaacgatgt catttaatat
    13021 tggaactaaa agagtacctc ctccagaacc aaaaactcca tttataaatc ctgtaaaaac
    13081 tccaattatc gtatttttta agttaaaatc aaagtatttt ttctttaaat catcagtttt
    13141 tttcataaaa atcaccttct gaaatagttt taccaaaata ggcaaattat atttatataa
    13201 aataagatta aatataatct ttcatatttg tttaattttg cataaaaaaa aacatattaa
    13261 aacaacatat taatatatgg tataatatat taaaacaaag tagcaaattt gagaggagat
    13321 aacaatgtca aatataaaaa tacaaataga caaaactgta gaatggctta taaataaggt
    13381 taatgaggca aatgcaaaag gattaattgt tggtgtatct ggaggaattg attcggcagt
    13441 agttgctaat ttaattaaaa aggcatttcc agaaaactct atgggagtta taatgagcat
    13501 aaaaagtaat cctcaagata gagaagatgc acttaaggtt atagagggat gtgatataga
    13561 ataccttgat ttagacctta tagaaccaca aagtgctata ttagacatgg tagtaggaaa
    13621 tttaaaagat aaacatttat atagagaaga atatttaaag atgacagatg caaacttaag
    13681 agcaagagta agaatgagta caatttatac aattgctaac aatctaggat atctggttgt
    13741 tggtacagac aatgctgcag aaatacacac aggatatttt actaaatttg gtgatggtgg
    13801 agttgatatt ttacctattg caaatttaac taaaggagag gtgtatgaat gggcaaaaga
    13861 gcttggtgtt catgaagatt taataaacaa agctccttca gcaggtcttt gggaaggtca
    13921 aacagatgaa gatgaaatgg gaactactta caatatgata gatgctgtgt tagaaggtag
    13981 attggatgaa gttcctaaaa gagaccaaga gataattgaa agacttcata gattaagtga
    14041 acacaagaga aaaacgcctg cacaacctcc taagttctaa tttactattt ataagatttg
    14101 tgataaaatt tacaagtgat gaaaattaga ataattaatt gtacgtatta aggagtggaa
    14161 atatgggacg tataggtaat ataattaata gaaaaggtaa acaagatgct caaagagcaa
    14221 agatatttac taaacatgct agagcaatag cagttgcagc taaagaaggt ggagcagatc
    14281 cagagtacaa tgcagcgtta aaaacagcta tagaaaaagc taaggcagat aatatgccaa
    14341 atgataatat agatagagct atcgctaaag gtgctggagc aggtgctgga gaagactatg
    14401 aaactatagt ttatgaagga tatggacctg gtggagttgc tgttatagta gaaactttaa
    14461 ctgacaacaa aaacagaact gctggtaacg taagatatta ttttgacaaa aacggaggaa
    14521 acttaggaac tagtggatgt gtgtctttta tgtttgataa aaaaggacaa atattagttg
    14581 gtttaggaga tggagtttca gaagaagaat tgatggatgt tgcattagaa gcaggagctg
    14641 aagatttcat aacagaagaa gatggttatg aaataataac tacaccagaa gatttttcta
    14701 gtgttcgtga tgagttaaaa gctaaaggat atgagtttat atctgctgat gtgaagatga
    14761 tacctcaaac tacaactgta ttgactgaag aatctcattt aaaaatgatg aataaattag
    14821 ttgatatgct tgaagaagat gatgatgttc aagatatata tcataactgg gaagtagaat
    14881 aaatagtata agcatattga aatttataag tattgaatca attttaacat gtgataaatt
    14941 ttatagaata agaaacacta aaatagacat acgcacctct aacctatatt tgcataataa
    15001 tatgtaagca taggtaaggg gtgtttttat atttataggt taagaaattt aaagtaaatt
    15061 ttgagctgga ctcgattgtc tataaataat tgatgggtat ataacttgtt gctgaatacc
    15121 atttatacgc ccagttactg tatcaataat catcctaaga ctacgttctg ctgtctcttc
    15181 catttttaaa tctataactg tcaaaggagg aatacttctt gccattagtc gtgaaggtcc
    15241 attacttgct gcaaatattt gaatatcctc tccaattaca attcccgatt catgaaatgc
    15301 attcatcata ccaagagcta ccacatcatg attacaaaaa attacttttt ttagtgaatt
    15361 ttttgcaagc attttttgag caatatcata tccactatct attttattag aacaataata
    15421 tatagaatct gatagatgta ttccatgttc tttacatgtt tttaaaaaag atttacccct
    15481 taaagtcata catgtaaagg aagttgggtt gaatacaaca gcaatatcat ttttaccatt
    15541 ttgaatagca tgtaaagctg ctatacgacc agtttcctca ttatcaatag atacacttga
    15601 aaaaccaggt atttcacgat ttacaacaac tacaggaatt ttaggtttat tttttactag
    15661 atattctata tcatcagcat tgatacctgt taaaacaatt ccatcataat aattatttgc
    15721 aaaaaagtat tcatcatcac atagatgacc aactttgtaa ggtcgtatga tgatatttat
    15781 gtttaaatgt tctaaagaaa ttatgtggtt tattgcttga agtatattgg ttgatgccaa
    15841 ctcaaatccc tcatcctgcc aataaaaagc tattttaata ttattatgtt taataggagt
    15901 agagcgttta tatccaagct tatcagctga atttaatata agctcttgtg tatgtagcgg
    15961 aatcctgcgt tcatttcctt taccacttaa gacgtacgag acagttgctg aagaaagacc
    16021 acagtctttt gcaatatctt tgattgttgc catgataaaa tcctccttaa atagttgctt
    16081 aaatttgctt ataccaataa tcttaacata tattcaacta aagaacaata ttctacaagt
    16141 tgcatatttt acaggattag aataaataaa tttaaaaaaa cttcttactt atgttgacat
    16201 aatttagttt ataggattat aatatgctta aataagctta taattaactt aaattaagca
    16261 aagttaagca gggacatgca atgctagctt gcaatgtgac tgtaaagggg gaaaaggtat
    16321 gagtaaggta aatatatttg aagttggtcc tagagatgga tttcaaaacc tgaaagagtt
    16381 tttagaaact gataaaaagc ttaagattat tgatggtctt attgcttcag ggattaaaca
    16441 acttgaaatt agttcatttg taagcccaaa agcaatacct cagatgaaag atgcaaaaga
    16501 agtagcaact tattgtgtag aaaaatatcc tgatgtgaaa ctttatgcat tagttccaaa
    16561 tttatacggt gctaaagttg catgggagtg tggtataaga gatatatcct atgttatatc
    16621 tttgagtgaa actcataata aaaaaaatat aaatcgtacc catgaagagt ctattgatga
    16681 gcttaaaaaa ataatgaata cttatccaga catgaatata tgtattggaa tggctactgt
    16741 atttggatgt ccttttgaag gtttaccaaa aattgaagat gccataagat ttgctaaatg
    16801 cctttgggaa aacggtatca gggagataaa tctagcagat acaataggga ttgctgaccc
    16861 taagcaagta agagaaacta ttagtgcatt agttgaagct ttaccagagt gcagatggca
    16921 agtacatatt catgatacta gaaatatggg aatggttaat actcttgtgg ctattgaatc
    16981 tggaattact actgttcagt ctacacttgg aggattagga ggatgcccat ttgctcctgg
    17041 agcatctggc aatactgcaa ctgaagattt agtatatatg cttgaacgta tggggtatga
    17101 tacaggagtt gattttgtta aacttcttga attatcaaag tatcagaaga gttttgtaaa
    17161 tggagtatat agtggtcatc atgtaaatat aaagtctgat agttgtaatt gttagttcta
    17221 ttgattaatc gattaaaaaa tatgttgatt aaaaaaatat gctgattggt aaaatagatt
    17281 tattgataaa aaatataaat tataaaatac attatctaat aaaacaaata aaaaaattga
    17341 gggggattag tatggatatt atagctttac ttttattttt aggagttatt attattgcat
    17401 ttgtacgtaa gaataatgca ggtattttgg ctctagctat tggtgtcata gctgttagaa
    17461 tttttggaat ggatgataaa gaactttatg gagctataag caactcaatg tttactacac
    17521 ttgttggtat aacactactc tttgcaatag tgaactcaac aggagcatta aagcttgttg
    17581 cagaaaaaat tgtagctgct tctggtaaac gtgtttggct tatacctata gcagttttta
    17641 tagcaggatt tgttgttgct ggtgttggac ctggggcaat tccagcactt gcaattatcc
    17701 cagcaatggc tgttcctgta gccataacag ttggttataa ccctgtaatg cttgcactta
    17761 taggtgaatg tggattaatg gcaggtcgta tgactcctat tactccagaa ggtcaaatta
    17821 taacaaccgt tgcagaaggg gttggaattg aaaatgttat gcctactatc ttagcctgtc
    17881 aaactctttc tacaattgta ttttcaatag tattgtttat aattttcaaa ggatataaac
    17941 ttaaaaaacc tataaatgtt atagatagta agcaaataga aaaattcaat ataaagcaga
    18001 taatttctct aataagcata gtagttatga ttgcttttat cataatcttt gatatgaatg
    18061 ttgggcttgc agcttttgca gtttcagctg tacttatttt tttcaatatt gctgatgaag
    18121 gagaatgtat caaatcaatt ccatggagca cgatagtaat ggttcttgga gtaggtgcaa
    18181 tgatgacaat cgtagatgca gcaggaggta ttgacttgat gagtaatgca ttatcatcac
    18241 tgatgaatag taaaacagct actccaatta tgagtatttc agcaggactt atgtctatgg
    18301 ttagttctgc tttagcagta gtttatccaa ctatgatgcc tatgtgtgtt gatatagcta
    18361 aggcagttgg aggagtagac ccactagcac ttattgctgc agttggtgtt ggaggttctc
    18421 ttgctggtgt aagcccactt tctactggtg gggcattgat tttagcagct atgggttcaa
    18481 gtaagaaaga ctttaataag gaggaacaaa ataaggtttt tgtacagctt ttcattatga
    18541 gtgcagttgg cttattggtt attgcagtag tatcaatatt atcatttaat gcaataacac
    18601 atttaatgaa ctaattagaa taactgaaaa taaatcatta aatttaactt ttaatattaa
    18661 tcaatataat ataatttgga ggggaagtta tgaaaaaagg agcattaagc aatataaagg
    18721 tacttgacct tacaagagtt cttgcaggtc catattgtac aatgatgttg gcggattttg
    18781 gagctgatgt tataaaaata gagatgccaa gaaaaggtga tgatacaaga ggttttggac
    18841 cttttgtaaa tggagagagt ttatactatg caaatataaa tagaaataaa aaaggtatca
    18901 ctctaaacct taaatcagaa gaaggaaaaa atatattttt agaaatggta aaacatgctg
    18961 atgttgtagt agaaaattac agaccaggtg taatggaaaa gttaggtctg ggttatgatg
    19021 agttggctaa agttaacaat caaataattt atggagctgt atcaggattt ggatgttatg
    19081 gaccatattc agaacgtcca ggttatgata ttattgcaca ggcaatgggt ggtcttatga
    19141 gtataacagg gcaagaagga ggagaaccaa cgagagttgg taatgctatg ggtgatgtac
    19201 taggtggaat gaatttaact attggtatac tcacagcact caacgctaga aaaataatag
    19261 gaaaaggaca aagagtagat gtttccctcg ttgattctgt tgtatcgtct ctcgaaactg
    19321 gtatacagag atactttgat tcaggacaac ctgaacttat gggtaataga tatgcttcag
    19381 cctatcctta tgactctttt aaggcaagtg atggaagttt tgtaataggc tgtggtaatg
    19441 acaaactttt tgaaaagtta tgtaaaaaag ttctttttag agaagacctt ttaatagatg
    19501 agagatttaa aacaaatctt aatcgttgtg aacattacaa ggctcttaaa ccagaaatag
    19561 aaaaatggtc tgttaagcat acaataaaag aagcagttga cttaatatca gaggctggag
    19621 ttcctgctgc tcctatctat aatcttgatt gtgttacaac agataaacat atagcaaaag
    19681 caagagaaat gattgtagat attagtcatc ctattatagg aaatatgaaa gtcaatggaa
    19741 atccagttaa gttgatgaca acaaaagcta aaattgatat gccagcacca tctctagggg
    19801 aaagtaacga ggagatttat aatggttggc ttggttttga tagtgataaa ataaaagatt
    19861 taaaagaaaa tggagttatt tgattaaaaa atagctaaac acacttgtga ctttagtcat
    19921 gggaggttca gttagaataa tatcaaaaaa tattaaatca atactgtaaa tcaaatatag
    19981 aattgtcaga agcatttaag atgggaaaag ctacttagac attgagtctt tgtggctttt
    20041 cctattttca ttaagaattt tatattatca gaatagatat gtactaaact aaagtattaa
    20101 caatttaaat taatagaaaa taaactacct aattatgttg aataaagact actttagtga
    20161 aaacaaactt atagagatgc tatttaaatt attttaatgg aaatatcaaa aatgagactg
    20221 cattctcaaa aatgagactg cgttttttaa gtattttctc gaaaatgaga caaaaatatt
    20281 gttttatggg ttttattgaa gaaaaattct tctgtgaatt acaatttaat caattttaaa
    20341 gttgaaaatt attaaaaatt tagtgaaatt tatgtatatt tcgtttattt tattaaaaat
    20401 aacaattttt tactaaaaat aaagaacttc aatggtgatt ggcatagtac ttgctatttt
    20461 atattaacaa gaaatgtaga aaaaataaca atgtataatg gggggaatat gatggaatct
    20521 gtaatggaaa atttgaacaa tcttaaggtg gaggttaagg acaaagtctg tgttattact
    20581 ataaatagac ctaaagcttt aaatgctctt aatagtgaca ctcttaggga actatcacaa
    20641 gttattgatg tagtatcaga aaatgaggca atattaggag ttattattac tggagaaggt
    20701 aaagtttttg tagccggtgc tgatatacgc cagatgcaaa actataaaag tgaggaaggc
    20761 agaaaatatg caggttatgc tcagggaatt tttgataaaa ttgaagctct tgagaaaaca
    20821 gtaatagcag cagttaatgg atatgcatta ggtggtggat gtgaacttgc tatgagttgt
    20881 gatattagaa ttgcatcaga aaaggctata tttggacaac ctgaagttaa tttaggagtt
    20941 attccatgtt ttggtggaac tcaaagatta tcaagacttg ttggaactgg aatagctaaa
    21001 gagttaattt ttacggggag acaagtaaat gcagaagaag ctaaatctat tggacttatt
    21061 aataaagtgg ttccaagtga tttactttta gaagagtcta tgaagatgat gaaccaaata
    21121 gttgaaaaag cgccaatagc aataagatat gcaaaagttg ttattaacaa agggatagat
    21181 atggatttaa agaatgctct tgaactagag aaagatgttg caggtttaac ttttgctaca
    21241 agagataagc aagaaggaat gaatgcattt atagaaaaga gaaagccagt ttttgaaaat
    21301 aaatagctat tataactaaa attggaacaa tgtagaatat attcaaaatc taaatttcgt
    21361 gaaaaaatac atatagttta attttaaaag gagttaattt atgaatacgg gagtaattat
    21421 aagtttagta gggattatca tagctctatc tcttctagtt gtaatggtta tgaagggaat
    21481 aaatattttt attatagcaa ttgtatgttc atcattagtt gctataacag gaagcctaaa
    21541 tgtgtatgat gcacttaaag tggattatat gacagggttt gttggatttc ttcaggcaaa
    21601 tttctttatt ttcctaacag ggacattaat gggaaaaata atggagatta ctggtggagc
    21661 aaaatctatt gctaagatga ttgtaagatg gattgggaag gataaagcac tactttctat
    21721 tccaatagct tgtggaatat tagcctatgg tggagtaagt gttttcgttg taagttttgc
    21781 agtgtttccg atagctttag aaatttttaa agaagctgat ttgccacgaa gatttatacc
    21841 agcagctttg acttttggat gctcaacttt tgctatggtt gcaccagggg caccacaaat
    21901 tcagaatatt gttccagcat caacattagg gacagatatt atggctggag cagtaaatgg
    21961 ttttatatca tgtgcagtaa tgtttatagt tggaagtaca attttgtaca aaatggtttc
    22021 aaaagaaaaa gccaatggtg gtcattttat agcacatgaa tcagatatat ttgatgaagc
    22081 agaagcaact aattctaaga gagaaaatgg tcccaatggt gtaattgcct taattccatt
    22141 gatagtgtcg attttaataa ttaatgtaaa agttaatgga aaagcgatag taccaattga
    22201 ggtgggagta tttattggag ctttattagt atatttattg ttaaataaat atcaagataa
    22261 tactaaaata gttggacatg ttggtgatgc atgtaaaact acagtagtag caatatgtaa
    22321 tacttgtgct gtagttgcat ttggttcagt agtaaaatca gcagttggtt ttgacttcat
    22381 agttaatgct atgactaata ttcctggtcc tcctattgca ggggctgcag ttggaactac
    22441 agttattgca ggtatttgtg ggtcagcttc aggtggacta ggaattgcag ctccacttct
    22501 tggaccagta tttttagcca agggtgtttc cgctgcagca ttaactagga ctatggcaat
    22561 ttcatcagca gcattagatt cacttccaca caatggatat attgttactg taacaaatgg
    22621 tctttgtaaa gaaacacata aggatgccta tatgccaata ttctgggtaa ctgttttaac
    22681 cccatttatt ggaaccatag tagcagtcct actgtttaca atgttcccgg gattgccata
    22741 ggagaaaaga taaaaggtat aaattatatt ttgatattat aaaatcaatt ttcaaaatat
    22801 atacaataaa tttcatgttt taatactgta aatatgtatt taaaataaca aattgaccat
    22861 ataaggagga attgaaagtg ttaaataaac cattagaggg agttaaggtt attgacctaa
    22921 cgtattttgt agcaggtcca gggacttcta aaatattagc tgactggggt gctgacgtta
    22981 ttaaggtaga gccaagcttt ggagacccag gaagaaagac aggggcaaca atgacaatgc
    23041 caatagatga ttataataat cctttttaca gcacatataa ttcaaataaa agaggtttgt
    23101 ctataaatct taagagtgaa actggaattg aaattatgga taagctttta agcgaagcaa
    23161 acgtatttgt ttcaagttat agaacaggag cattaaaaag actaggtctt gattatgaat
    23221 cattaagtaa aaagcatcca caccttatct ggggtcagat aaatggtttt ggcgattttg
    23281 gacctgctaa ggataatgca ggatttgata cagttgcctt ttgggcaaga agtggggcta
    23341 tgcttgatat agcagaaaaa gatacaagtc caataaatcc acctatagcc tttggagatg
    23401 caacaacttc ttgtagttta tctggaggaa tatgtgcagc tttgtaccag caagctaaga
    23461 ctggaaaagg acaaaaagta atggcatctt tatttgggca agcaatatgg aatgcatcat
    23521 ctttattagc atctacacag tttagtgatg agtatccaaa aactagaaaa aatgctattt
    23581 caccagtaat aaattcttat cgttgtaagg atggaaagtg gatattctta agtattttag
    23641 agcatgaaag atattttgag gcactttgta gattatttgg aagagaagac ttaataaaag
    23701 aagagaaatt tgcatcttca gtagaaagta agaaaaatgc tacagaactt attaatattt
    23761 tagatggtga atttgcaaag tttactcaaa atgagatggt tgaaaaactt actgctgctg
    23821 atatagctca tgaaaaaatt caacatgtta atgatgtagt gactgatgaa caggctattg
    23881 ctaataacta tatatatgaa catacaagta aagatggaaa taagacaatg cttgcatcta
    23941 ctccagttaa atttggaaat attgaagtta acatgacttg tgatgctcca cttataggag
    24001 aacattcaga tgagatattg agagaacttg gatacagtga ttctgatata gagactctaa
    24061 ttgaatctgg aattgtaaca atgaataaag aagcatgtga aatatgttaa taaacatgtg
    24121 aagtatgtta ataaatagga gggaatttta tggattttag attaacagaa gcacaattaa
    24181 tgcttcaaag agtagcaaaa gaatttgcag agaatgaaat agcaccaata gctgctgaaa
    24241 cagataaaac aggtattttt ccaagggagc tttttagcaa aatggctaaa ataggattta
    24301 atggaattgg aacacctgta gagtatagtg gttctggtgg ggcagatata gaaaaggtaa
    24361 ttgttgttac tgagattgcc aaaaaatgtg cagcatctgc agcaatatta tcaatacaca
    24421 caatatatgc tcaagctatt ttgaaatttg gtactgagga acaaaagaaa aaataccttc
    24481 caatgatggc tgaaggtggg tgtgtaggtg cttttgcctt aaccgaacct aatgctggtt
    24541 cagatgctgc gagagctgca acaactgcaa ttattgatga agaaactgat gaatatgttt
    24601 taaatggaac taagtgtttt atttctggtg gaggtcaagc agaatcatta ataatatttg
    24661 cattgacaga cccatcaaag ggaataaagg gaatgtctgc tatcattgtc gacaaaggta
    24721 ctccaggttt ttcaatagga aaaattgaag aaaaaatggg tattcatggt tcagaaactg
    24781 cagagttaat atttgataac tgtagagttc caaagtctaa cttattagga aaagaaggta
    24841 aaggatttaa tatagctatg acttgtttag atggagcaag aattggagtt ggagctcaag
    24901 ctgtaggaat tgctgaaggg gctttagaag aaagtatcaa atattctaaa gaaagagtcc
    24961 agtttggcaa gccaatttca gctttgcaag gtattcaatg gtatatagca gatatggcga
    25021 caatggtgga atcagcaaaa ttattagtat attatgctgc agatttgaaa gctagaggag
    25081 aaaaacacac taaagaagct gctatggcaa aatacaatgc gtcacgtact gcaagagagg
    25141 ttacaaattt agcccttcaa atccatggtg gatatggata tatgaaggat tatccattag
    25201 agagaatgta cagagatgcc aaaataacag aaatttacga aggtacttca gaaatacaca
    25261 aagttgttat ttcaagagca gtactaggat aggaggaaaa gaatgaatat agttgtttgc
    25321 ttaaagcaag ttccagatac taatgaagtt aaaataaata aagagacagg tactctaata
    25381 agagatggtg taccaagtat aatcaatcca gatgatagaa atgctttaga agaagctcta
    25441 aaaatgaaag atgaactagg agcagtgatt aaggttataa gcatgggacc tcctcaagct
    25501 aaaagtgctt taaaagaagc tttggcaatg ggagctgatg aagcttattt aatctcagat
    25561 agagcttttg gtggttcaga tacttgggct acatctacaa ttattgctgc tgctatagag
    25621 aaggttggaa agtatgatgt aatattctgc ggaagacaag ctatagatgg agatacagct
    25681 caggttggac cagaggttgc agaattttta gggataccac aagttactta tgcgaaagaa
    25741 gtaaaggttc aagatgacaa attactagta actcgttata cagagacagg ggattattta
    25801 atagaagcaa agatgccagt tttattaact gctataaaag agttaaacaa tccaagatat
    25861 ccaagtgtca agggaatctt agaagcttat aataatggag atgcaaagat tactgtatta
    25921 acacttgcag atttagatgt tgatacaact caaattggat taaagggttc acctacaaac
    25981 gtttataagt cttttgtacc agttaaagac aagcataatg aaataataga aggtataaat
    26041 aaaaaagaaa aagctgagaa actaatagaa atactattcg atttgaaact agtataggag
    26101 tgttaagatg atgagagcaa aagttaatca aggtataaat ttaaatgatt ataatggtgt
    26161 ttgggtaata ggagagcaaa gggaaggtaa aattaatcct gttacgatag aacttattgg
    26221 tgaaggaaga aagcttgctg accaattagg aaaagagctt gcagttgtga tagctggata
    26281 tgaagtagag aaagaagtga aggaattact tcactatagt gttgataaag tatattacat
    26341 caatgaccct cttcttaaag atttcactac tgatggatat gcaatttcaa ttgcaaattt
    26401 aatcgaaaga aaaaagccag aggttgtatt ggttggtgct acttctatag gaagagatat
    26461 agcgcctaga attgcaggta aggttggaac aggtctaact gctgactgta caaaacttga
    26521 aatagattca acagataata agttattaca aacaagacca gcatttggtg gaaatttaat
    26581 ggccactatt gtttgtccaa aaaatagacc acagatgtca acagttcgtc caggagttat
    26641 ggcaaaagct gtaagaaacg aatcagagac tggaatttta gaagttgtta ctccagaact
    26701 tactgaaaaa atgattagaa ctagattagt agagatactt ccacaagaaa agaaatctgt
    26761 aaatctaact gatgctagaa taatagtatc agggggaaga ggattaaaaa gagcagaagg
    26821 atttgagctt ataaaagaat tggctgataa attgggggca gagattggtg cttcaagagc
    26881 agcagtagat tcagggtgga tagaacattc tcatcaagtg ggacaaacag gaactactgt
    26941 tagaccagaa ctatacattg catgtggaat atctggagca atacaacatt tagcaggtat
    27001 gagtgattct aaatatatag ttgctataaa taaagatgca aaagccccta tttttagtat
    27061 atgtgactat ggaatagtag gagatttata tgaaattata cctgaaatga tagaatcatt
    27121 aaataggtaa cttttagaaa acattgaata tgtagaatga taagtcttat aatattgtat
    27181 tgtaagactt attatttttg ctgaaggtta tagtggggag atgaaacaat gaaagagcag
    27241 tggtataagg atatatttgc aagagtatta tctatgactg atgatggttt tattgttgta
    27301 aatacaagtg gagtaataat agatattaat gataaatatt gtgacttttt aggaaaagaa
    27361 agaaaagata taataggaca aaatatacaa agtattatac caaatacaaa aatgctagat
    27421 gttatgaaaa ataagtattg tgaagaagga gctatacatc attattcagg tggaaataca
    27481 aaagaaaaaa gtgtaatagt aagtaggtct tatgtggaaa atgacaatgg agaagtagtt
    27541 gcaggagtag ctcaagttaa atttagattg caatcatttg atgtagctaa aaagttaatg
    27601 tcagaatata tggagctcca atattataaa gagcagttta aggataactg tggttttgac
    27661 aagctcatag gtgaaaatag agacttcata gaacttaaga aaacaggtgt gaaagcttct
    27721 aaaacaaact ttccagtact tttaacgggt gaaacaggca caggtaaaga agtttttgct
    27781 agagcaattc acaataatag cagtaggtca gataaaccta tggttagtat aaattgcgct
    27841 gcaataccag aagaattatt agagtcagag ctatttggct atgacgaagg agcttttaca
    27901 ggagcaaaaa agggtggtaa aaaaggtaaa tttttagttg cgaataatgg tacaatcttt
    27961 ttagacgaga taggtgacat gcctttgacc atgcaagcaa aacttttaag agttcttcag
    28021 gaaagtgaga tagaaccagt gggaggtctt aaaactataa agatagatgt aagagtaatc
    28081 tctgccacaa gaaagaattt aagtaaaatg gttgaagagg gattatttag agaagaccta
    28141 tactatagat taaatgtaat aaacattcat atgatggaat tgaaggacag gcaagatgat
    28201 attttattgc tagcaaatta tatattaaac aaattaaatg ttgaatacaa ggaattgaag
    28261 gttttaagtg ataaggttaa aaattgtttt attaactata cttggccggg aaatataaga
    28321 gaactacaaa atgtaataaa aagtgcctat gctgtaagtg atgatatggt cattatgatg
    28381 tgtgaccttc catctaagat ggataatatc agcagagtag ctcaatgtaa tgtggatagc
    28441 aattgttcaa ttcatgaaat ggttgagaat tatgaaaaga gcttaattat tgatgtgtta
    28501 aggaagtata attggaaatg ttctaaggca gcagaggtta tgggaataca caagagtctt
    28561 ttatataaga aaataaaaaa gtatgaaatt gaattaaata attaagataa cttgaattaa
    28621 ggcaatgcta aaaaagcgcc cttattcaaa gcgaactgta taaactgttt tatgcagtta
    28681 aaacgtgtaa aagtagatgt gaagtactaa tgtcaatcat tagtactttt ttattatatt
    28741 tataattact atctatattt cagtatcttt tgatatctaa gattattatg tttaatttag
    28801 tatataacaa aaccctctta gttatggaca gttttttata ttttaactgt ctactaagag
    28861 gggatagttt agtttaaatt tagagtaaat tttatctagc atttataaaa aatattttga
    28921 atagcttttt tgttatttag tcataatttt ctacttcttt atcaagttct ttgccacaag
    28981 aatcacactt atatatagca ttgtatccgt aatcatattc atcaactatt ttcttttgtc
    29041 taaatacacc accacactca cataggaaac caatttttat aagtgtaacg ataaattgtg
    29101 attttataaa ttttatatca ttgcatttat cgttagtgta aaatgtataa atataagagt
    29161 tatcgcactc atctcttaat tcaaatcttt caatatatgt gttatttttt aattcctcaa
    29221 attcttcttt agttaaatat gatttttgtt gcaattcatg taaacgctta atttggtcca
    29281 ttatttatat cctcccaata attttagtat tttaagctta gataaggaat ctaagtttta
    29341 ttaaatttat cccaaggaat tatttaaatc atatttagtt ttattaatta caacatatat
    29401 aaattacacg aaaataaaac taattgtaaa aataatatcc tgtgaaaacc taaactacta
    29461 accccttact aacccgaaaa ctaaaaaaag aaaatatatc caaatataag tgatatataa
    29521 ataaagatgt ttcatataaa tttaacttta aatattctga caataatata tataaatata
    29581 ttatagttaa aatataccac atattttggg tattgtatac tggaattaga gtaattaatt
    29641 tattttttaa catacaaatg attttatgaa aaaaaacaag actcaaaaat ttttatattc
    29701 tttgatagaa taaaattgag agtaaattta ttgaatttta taaaatttat aaggggtgag
    29761 tctaagatat gcatgaagat aaaaatgata tatttgaatc aatagatact gaggattttg
    29821 ataataaaac agaagaagaa tgtttagagc tagtaagaaa aaatggattg aatttaatat
    29881 acataaaaaa tcaaacagaa gagatatgtc tagaggctgt tagacaaaat tgtaatgcaa
    29941 taaaatgtgt tcagaatcag acagaaaaaa tatgtataga agcagttaaa caagattgga
    30001 gaatgttaga atttgtggaa gagccaacag aagaaatttg catgttggct attaaccaag
    30061 atggaacagc attaaaatat atagaaaatc agacagagga gttatgctta agagccgttg
    30121 aaaaaaatgg tgcagctttg gagtatgtaa aagaacaaac agaagaaata tgtatagaag
    30181 cagttagaaa cagcgaattt ggattggcaa gagtgaaaaa tcaaacagaa aaaatatgta
    30241 tggaagcagt taagcattgt agctataatc taaaatgggt agaaaatcaa acagaagaaa
    30301 tatgtatgga agcagtgaga caaaatgggc ttgatttgaa atttgtaaaa aatcaaacag
    30361 aaacaatctg tttaagagca gtaagacaaa atggaatggc attagaattt gtaaaggaac
    30421 agactgttgg tatatgctta aaggcagtaa gacaatatgg aatggcatta aaatttgtaa
    30481 aggaacaaac agaagaaatt tgtacagaag ctataaaaca agataaaaga gcacttagtt
    30541 ttgtaaaagg agataaggaa aaatataagg ctctatatga taataatgaa ccatttgcaa
    30601 agagatatgt tagaaatgta atagaaaaag aaaacagagc attgattaaa aaaggagaag
    30661 aaaatgcaaa aatcaaaatt gcaggaaaac tttatgatag aggcatgtct tttgaagata
    30721 tatcagatat agttgagatt gaaataagca agttaaaagt gagtttaggt gttttttaaa
    30781 gtaataaatg taggtgtttt ttatgggaaa tagttaataa aaaaataatc gactagctct
    30841 ttgtaggaca gcaaaattag tgatataatt tgatgtataa taaattattt ttattagata
    30901 agggggaatt aaagttgaag attacagtat tataccaaac aagaagtgga aacacagaaa
    30961 gggtcgctaa gctgatagaa gagggcgcta aaaaggtgga tggagtagat gtaaagctta
    31021 tgagacttga taatattgat ttagattatt taaatgaaag taaagcagta atatttggaa
    31081 cacctactta tttagcaaat acaacttggg aagtaaaaaa atggtttgat gaagattcaa
    31141 aaaaagttaa tttagctgga aaattaggag ctgtttttgc tacatgtgat tatatatgtg
    31201 gaggtccaga tgttgcgata cttactatag taggacattt gatggttaaa gggatgcttg
    31261 tgtattctgg aggtggttct ttaggaaagc catttataca tttaggacat gtacattcaa
    31321 ttgaaggtcc agagttacaa gatgagaagg ctataatatt tggtgaaaga attgctacta
    31381 aggcaaaaga actatttgct taatttctat atgcatagta atgattagag taaatttagg
    31441 gttttaatgg agatttgaag taaaagttat aaaataaaaa attttccata aaattactca
    31501 agatgaatta taatataatt ataaataaat tatattatta aaatatttaa aatcaaacgt
    31561 caatagcgag ggaagtttat ggtatggcat atagaatatg agattttttc tgcaattata
    31621 gttatttttt taatggtata cttttttaga agtaaattta tacctacttt acaaaacaaa
    31681 atatattgtg cacttttaat attctcattt ttatttataa tttcaaatat tttaggttca
    31741 ttttgtctaa ataatataga caaaattcca atttttatta cttttttatt gaatcagata
    31801 tacttattgt tattgccaat accagcagca cttgtatcat tttatgttat ggctattatt
    31861 tatcaagata taaggtatat gaaaaaaaga ttattatttt tatctatacc acttataatt
    31921 tgtataatct tatctattac aaatcctttt acgcatattc tatttggatt gtcaaaagaa
    31981 acaggttata tacgaggttg tggatatgtt gcaacttttg catctttttt cttttatgca
    32041 atatattcag catttttatc ttttaaatat agaaaagcaa tgcatgaatc aaaaatatgg
    32101 gctattagag gttttcttat agtttcaatt gtggcaatta tcttacaggc aattttttta
    32161 cagtatcttc ttacaggaac tgcatgtgca tgtagtttac ttttgacata tctttctatg
    32221 cagaatcgag gtcttattat tgatgacctt actggtgtac tcaatagaca atcttttatt
    32281 caagagctag atttgaatat caatactgaa caatcaggat ttattattac aattgcgctt
    32341 gatgatttta agtttatgaa tgaaactttt ggaacaaaaa atggagatat tgcactaaaa
    32401 gaagttggaa aatatttgat tcagatacat gatgtaaacc atgtatatag aataggggga
    32461 gatatatttt ctattgttgt caatagtcaa ttaggtatag aaccagatga tattatcaga
    32521 aagatagaag aaagatttaa aaagccttgg ctagtagaag agataagttt taatttagca
    32581 actagtattg ctgttgttta ttacccagaa aatgcagaaa cgacagaaga tgtaattgtt
    32641 gctatagatt tctctataca tgaagcaaaa cgctctgagt caaggcgagt tgtttatgca
    32701 gatgcgtcta taagtgaaaa gataaagaag aaacatgtta ttaaaaattg tttaaaagaa
    32761 gcattaaaaa atgatgggtt tgaagtgtac taccaaccta tattttctaa tagcaggggc
    32821 aggtttactt cagcagaggc attacttagg ctagaacaca aagagttagg ttttatacct
    32881 cctgatgaat ttattccaat tgcagaacaa acaggattga ttaactcaat tggattagta
    32941 gtctttgaga aggtatgtag atttatagct agtgatgagt ttgaagattt aaaattggat
    33001 aatatagctg tgaatctttc tgtagtacaa tgtatgcaaa aaaacttagc tgatgattta
    33061 ctttatctta tgaataaata taatgtatca ccaactaaat ttaaacttga aattactgag
    33121 actgtggcta tgggctcttt taatataatt aaagaaacaa tggaaagatt aattgattta
    33181 ggtgttaagt ttgcacttga tgattttgga attgcttatt ctggagttac taatatgctt
    33241 tctttaccat tttcagtaat taagttagat aagagtttga tttggtctat gaatgaagat
    33301 agtaggcata aacttacagt tgagacgatt atagcactta taaataaatt gaatatgaag
    33361 gctgtagcag aaggtgttga aaccattaag tgtgctgaag atttaatagc tatggagtgt
    33421 gaatatttgc aagggtatta tttttctaaa ccagttccag aagatgtttt taaaaatttg
    33481 ttgaaagaaa atacttttac aagttaacac cctttatttt tttaattaca actttgttca
    33541 ttgacactgc cagcgatata ttataaaatt aacacaataa taaatattaa atttattata
    33601 catattatta atattaatta atggagtaaa gatttattat atattttatt taattatcct
    33661 aaagtgagaa aggaagatgt gacatgaata aaaagaaaat attagtgcca attgatggga
    33721 cagaaagaag tatgcattct ttggaattta taaaaggaat atttaaaaaa gatgaagttg
    33781 aagtagaaat aatgaatgta aaagaactag tatttattga tggcatatcc ctggctgaag
    33841 agataaaaaa ttctgaaaat ttaggaagaa gaatcttgga taaagcagca gagataatgg
    33901 gagagtatga tgttaaagta cattttactt ttggatatcc aggagatgag ataattagaa
    33961 aagcaaaaga agataatgta gattttatag ttatgacaaa atctactaaa aaaggtctta
    34021 caagaatgat aggttcagta acagcaagtg tagttaaaca agcaaaatgt atagtgatga
    34081 ttgtaccgga gtagaattag aaaggtattt gaaatatgaa taaaaagata gtagcagttt
    34141 gtgaaagtga aagaagttta aattctctta agacagctgc aaatgattta ggatttgatt
    34201 tagtttatga aattcaagaa aatgataata taaaaaatga actttctatt tatgatatag
    34261 aagatgcatc catagtgtta tttgttacaa gtgattctat agaaagcata gagaagattg
    34321 atagatttat agatagagaa ttttatgaag ttgatccaaa gtatataata gaggatgcaa
    34381 aatctatagt aagtgaaatt ttaatagact taaattaatc gtgggtgtcg cactaagaat
    34441 agagcgacgc ctttttatat attttacaca agaaataaag aggttgtatc aaaatataga
    34501 taagagtctt tttcattgtt gaaatgatga aaatatattt gatttcatac aaaaaagagt
    34561 acctcataac taaaaagttc actttgagac actccatttt tatatgttag ttgcatttaa
    34621 ggtaaaatag aagtttaatc atgttgaaat aactgaatta catcttctaa atgattgtac
    34681 attgatgtat aacctaagta agagtcttta ctatcaaatg caatcattat cttgttatgg
    34741 tggctaatca tatccttgag agaatttcta tatttaaaac caaagtattg gttagaagaa
    34801 actgttttag gtattaactc ataatatttt ataaaaattg gattatgaga agctaaaatt
    34861 atctctttgt gaaattgcaa gtcagcatca taacattctt ctatcaaacc atgagaaacc
    34921 ttatccaatt cctctattga ctttaggtaa gtatatttta ttttttgaag ttctttagat
    34981 gtagcattta aaattgctag tttagtagct tcgctttcga taagttgtct tgctcttaaa
    35041 gattctacat aaaattcttg tatgttatga tttttataga tttcaccatc atcaaatagg
    35101 tcaacttttt taaatccttc aactatagga cttgaataag gcacagctct aagtattcct
    35161 tccttacaga gtatatttat ggcatttctt acaggtattc tacttatgtt aaataggtca
    35221 gcaatctttc tctcacttgg taatttacta ttaattttaa aagttccatt tagaatgttt
    35281 aatttaatat aatcaataat tttttcagtg gcatttaagc ttttcataaa aactcctaaa
    35341 catataattt ttttatgatt gtattatatc atagttaaga gttaaatcta cttttttata
    35401 atatgtataa gacaggatag aggccaaaat agctataata gccaagataa agtatccata
    35461 ttgtattgaa gtatattccg atattttacc aactatcatt ggaaatacag acattcctat
    35521 agcataaatt gcttgaaaaa aacccattgc agtagatttc tgatgttttg gtacattttt
    35581 catagactcg ctagtaaggt aagaaaggag tatacctgta gatatacctg gtagtacttg
    35641 tagtacaaat attatattaa tattttttat tgttggaact aaaaagcaat aggctgaaac
    35701 taaaataaaa actaaaggaa tccaaaattt tggtccatac ttagtacaaa atttagtaga
    35761 agcaaagcca gaagaagcaa cagcacacac catgtaaaat atagaagata gacctatgag
    35821 ggtagaacta gaacctaagt ttttaagaat ttgagtagta aatgacattg ttgtagacat
    35881 ttgaataccc tgttgaatta atgccataaa ggaaaaaaat acaagtcttt tatccttgca
    35941 gatagataaa tattttttaa ttgatatttt ttcaggtatt tttttagaat tatgattttt
    36001 tatatttaag gctagaatcg ttccaataac tgaagacaat acactcatga tacataaggc
    36061 tgtcattcct aatttttcat aaaataaagt actcataaca aatccaatca acattcctag
    36121 attgtttacc aatattatcg tacttgtagc tttttgttga tgttctgtag aaaaaaagtt
    36181 ggtatagtga accatgtaag aaatccaagt tgatgatgat attccagata aaatgttagc
    36241 tataagaaaa ccattgcctc caggagaaaa gactcttata agagatgcta aaccagcaaa
    36301 gaaaattcca gacagtataa atattttatg tttatttatg gaatcagcaa atactccaac
    36361 aggaagcctt aataaacatt gtgatattcc atatgcacct attattatac caatcatatt
    36421 tgtagataca ttacatgcac ttaaatatgg attttggaaa ggtatatata catattgtga
    36481 aaaccagaaa aatgtaacaa tagaaagtaa aagtaatttt tgattagata tttttttcat
    36541 attatcctcc atgtggtatt tttataatgc aaataatata ccatttagat tttttaatca
    36601 agtactttct ctattaaaaa aaatttaaat atataattat tatttacaaa aaaattatac
    36661 tttatagttg aattaagaaa acgcttatga tactataaag ttaacaaatt tgaatatata
    36721 acagtagacg tgttactggt aatgcaggca agatcgaatc aatttttata gattatctat
    36781 agagtactat gggtataatc tatttatttg gttcgatttt tttgtttaat tggccataaa
    36841 acaaaaagcc tatagttgaa aatggaggat tttttatgga ttataaaaat atagctcaag
    36901 aaattctact aaatgtagga ggaaaagaga atgtaaatga agtgactcat tgtatgacaa
    36961 gacttagatt taaagtcaaa agcgcttcta aagtgaataa ggataaatta tctaaaactg
    37021 aaggagtaat aactgttgtt gagagtatgg gtcaaataca agttgtaatt ggaaataaag
    37081 taaaaaaagt atatgatgag gtcataaaaa ttgtacctca atcaaataac ataggtaaaa
    37141 agaatgaaag tcaagaaaag caaggtataa ttaattctat attatcagca gtagctggta
    37201 tatttacacc tacaatacct gctatagcag gggttggtat gattaaaggt attttatcag
    37261 ttcttgctat gtattatatg aataaaaatg gagtagatat aaaagaaacg caaagctata
    37321 ttatcttaaa tgctatggct gattctatat tctattttat gcctattata ctaggatata
    37381 ctgcggctaa agtatttaat gcaaataaaa taatatctat ggtattagga gctacacttt
    37441 gttatccaac ttttactgct ttgatggcag gtgaagaatc tgttagattt ttaggattgg
    37501 cagtaacaaa agctacgtat acatcatctg ttattccaat aattattgct atatgggctc
    37561 tttcatacgt tgaaaaagta ttagaaaagt atatacctga ggtaattaaa ataataatgg
    37621 ttccaacttt atcattggta gtaatgttac ctgcaacatt atttttattt ggaccaatcg
    37681 gaatttatat aggaaatgtc ataaactttt cttataagta tatttatgaa ttaagcccag
    37741 cattgtgtgg agcatttgta ggtgggttat ggtgtgtgtt agttatattt ggtgctcata
    37801 gagcattatt accaataggt ataagtgatg ttgctcaaac aggaagacaa aatttattgg
    37861 cgtttgcagg agctgcaaac ttttcacaag caggggctgc tctaggagta ttctttaaaa
    37921 ctaaaaatca aggactaaaa acaatttcta tgtctgcaac tataacagct ttatttggta
    37981 taactgaacc tgcaatatac ggtgccaatc ttagattaaa aaaacctatg gtatgtgccg
    38041 taatatgtgg tgcatttgga ggtgcgataa tgggaatggg tggagcttat ggtaatgcat
    38101 ttgcaaacca aggtgtttta actatacctg tatatgctga agcaggtgca ttaggtttct
    38161 taagttatct aggtggttgt gctatagcat tttttggttc agctatttca acttatctag
    38221 ttggatttga agatttggaa gagtcttcta ataaggaaaa ttcatctata aaagtagaaa
    38281 cgaaggatgg tgttattgat ataacttcac ctgtagaggg cgaatgtata gaattgtcag
    38341 aagtaaagga tgatgtattt gcttcaaaag ctatgggaga aggtatagct gtgttaccta
    38401 caaaaggagt aataacagcc cctactgatt gtgaagtagc ttctttattt ccaacattac
    38461 atgcaatagg attaaaatta gataatggag cagaaatgtt aatacatgtt ggaatcaata
    38521 cagtagagtt aaatggtaaa tactttacaa aacatgttaa tcaaggagat ttagtgaaaa
    38581 aaggtgataa acttatatcc tttgatatag ataaaataaa aaaggctggt tatgatgtaa
    38641 ctacgccagt tatagtaaac aataca
//
LOCUS       DAEQCW010000029        36486 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.029, whole genome shotgun sequence.
ACCESSION   DAEQCW010000029 DAEQCW010000000
VERSION     DAEQCW010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 36486)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 36486)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..36486
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.029"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(275..1156)
                     /locus_tag="KRO40_001470"
     CDS             complement(275..1156)
                     /locus_tag="KRO40_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline iminopeptidase-family hydrolase"
                     /protein_id="HBH2092292.1"
                     /translation="MKITEGYMPFKGFKTYYRIVGENTEGKKPLVLLHGGPGSTHNYF
                     EVLDKIAESGRQVIMYDQIGCGNSFVEGHPELFNADTWIEELIELRKHLGLDEIHLLG
                     QSWGGMQAIWYAIEYKPKGIKSYILSSTLSSAKLWEKEQKRRISYMSEVDQKALLDAV
                     NTGDYSSKEYNDALERFMEMYCAGEVTEDSPECLRRPKKSGSEAYIVGWGQNEFSPTG
                     TLSGYEFTDRLHEIKEPCLVTSGAIDLCSPYIAKTMYDRIPNSKWELFEYSRHMPFVE
                     ENEKYIKVLTEWLNAND"
     gene            1612..2586
                     /locus_tag="KRO40_001471"
     CDS             1612..2586
                     /locus_tag="KRO40_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092293.1"
                     /translation="MNNINSLKVIKLSLGCSLAIFIAWLLKLEYSMVAGVIVLLTVKD
                     TKRETLKGSIGKIYGFLLCTIFSYLCFNILGYNLTSFSIFIFIIIPLCFLLNIQDVIA
                     MCVVIASHYYLQGETSIKWILNEAGIFAVGTGIGVLINMYIPTNIHKIHEVQKKLQEE
                     VSIVLIDIADIIVNPKKENGYSRDLYTLNSLIDSSISETYDNINNTLLSDTRFFLEHM
                     DIIKSQRDILENLYSYVSQLNSTPPQAHILSAFIHKIGYTEFEAETGNLLLEELKRLM
                     ISMKNQPLPVDRTEFENRAILFLCLTELKQFLVNRKHAQMLRDNNFYK"
     gene            complement(2702..3763)
                     /locus_tag="KRO40_001472"
     CDS             complement(2702..3763)
                     /locus_tag="KRO40_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH2092294.1"
                     /translation="MKKIRKLATKLLITTIVLISGMSMTVYGMTAKEVTAKTPKSYVT
                     GTNSVYGPKLSQAQLNSVAQATADFMNKKITKNMTTDAKILVAYNHIKNNTTYVDWNA
                     VEGANTAYTLVTKKGACSGMARSMKALCDAMGIESYYVHSTSNDHQWNLIRFGDGRLY
                     HVDIDANKSAGKDIIYKSLSHPLPFDKTAYPKVGAIVQTVKPEQTQKPAPPGKHTMLP
                     HQEGAKAVANFGKKGEDINEKHVMYEGVRCSVVNSSVNTITFTGSESNLDPSNLTIAV
                     IGFMNTPYGMFALAPEGKPVEYPFKYDKPFSLDFSGKNRSGAELAKYCKKNDVTIKIE
                     ITDEKANIGLGQIMYVRYE"
     gene            complement(4374..5225)
                     /locus_tag="KRO40_001473"
     CDS             complement(4374..5225)
                     /locus_tag="KRO40_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2092295.1"
                     /translation="MSCILKLKQIYEDLTEVDKKIADYILNNTEAISKLSVSELASNS
                     KTSTASIVRFSRKMGYSGFGDLKIEIAKDLMGKENEYTYVDENYDCNIDSVINKITNK
                     NIETINQTRLLNEKDIIKEAVEQIIKAKNVYIFGVGGSALVALDLQMKLLRINKQAFT
                     SLDSHTQLMVSSNVDKEDIAIAISYSGESKEVIKSIENAKLKGCKVICITKYSDNHLS
                     KISDLKLVVPNIEKRLREGAISSRIAMLTLIDIIYISIIQENLNEAEQKLQETKRILD
                     YLNINNA"
     gene            complement(5242..6162)
                     /locus_tag="KRO40_001474"
     CDS             complement(5242..6162)
                     /locus_tag="KRO40_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA reductase"
                     /protein_id="HBH2092296.1"
                     /translation="MYFLGVDGGGTKTTFTLVDEELNIVGTITKGTCHYNQIGFDNLT
                     KLLITGLEEVCKDAKINVEEITYAFVGLAGYGKIKEVLYALEVATKNAYSHINYTLGN
                     DVEIALAGSLNGEKGINIIAGTGSIAQALDKDGNLHRCGGWGYVLGDEGSAYYIGMAT
                     LKMFTMQSDGRCSKTKLYDLIKRHLNIENDYDIIKYVNDEIQGDRIEIAKFATICLKA
                     VIEGDNTASKIFDDAAYELSRLIIGLEHHFEQGTKIKVSYSGGVFKSGDLILEPLKKY
                     LNKTRFGIVRPVLTPDLGACLLAKKKYYSK"
     gene            complement(6272..7186)
                     /gene="murQ"
                     /locus_tag="KRO40_001475"
     CDS             complement(6272..7186)
                     /gene="murQ"
                     /locus_tag="KRO40_001475"
                     /EC_number="4.2.1.126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramic acid 6-phosphate etherase"
                     /protein_id="HBH2092297.1"
                     /translation="MLIKTLENLVTEGRNKNTLQIDKEDTLGIIELINNEDKTVAYAV
                     EEQKESIAKAVNIIVDRMKQGGRLFYIGAGTSGRIGILDATECPPTYGVDFELVQAII
                     AGGNQAIFKAIEGAEDDKELGKQDIIDRGVTSKDVICGIAASGRTPYVIGAMEYAKEL
                     GCAVLSITMNPNSEMSKKADLPINIIVGAEVIMGSTRMKSGTAQKMVCNMLTTASMVK
                     MGKVYSNLMVDVKTSNEKLVERAKRIIMIATNVKYDVAEKFLEEADNSVKLAIFMIKS
                     GLDKDSAKSILDRQEGYISEALKSIEKL"
     gene            complement(7285..8382)
                     /locus_tag="KRO40_001476"
     CDS             complement(7285..8382)
                     /locus_tag="KRO40_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBH2092298.1"
                     /translation="MGRLGISIYPEKTTSKEIYDYIDKAAENGFTRIFSCLLSVKDTK
                     ENIIKKFKSINEYAKFKGFEVILDVNPRVFGELEISYKDLNFFKKTKADGIRLDMGFT
                     GSEEALMTFNPQNLKIEINMSNNTNYIDTIMDYQPNKENLIGCHNFYPHRYSGLNLEH
                     FIKCTERFNKYGLRTAVFVTSQNETTFGPWPVTDGLPTIEMHRNLPIDIQVKHIIAMN
                     NINDIIISNCYPTYEELKVLGSMRKDMVTFDVAIEENIREVEKKILFEEIHFNRGDIS
                     DSLIRSTQSRVKYKGYKFELFNTPKIIKRGDIVIESSEYGHYAGELQIALTDMKNSGK
                     SNVVGYIRKEELFILDYIKPWQKFNFKPSTK"
     gene            complement(8615..9961)
                     /locus_tag="KRO40_001477"
     CDS             complement(8615..9961)
                     /locus_tag="KRO40_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2092299.1"
                     /translation="MLDKFTEFLDTKLSTSMARLAEQRHLRAVRDGIVASLPLIIVGS
                     FFLILAFPPLPDSWGVTQYLKENAVTILLPYRMTFFIISVYSTFGIGYSLAKSYKLDG
                     LTGGLLATATFLLTIVPTAIEGLTPDLLKIVEKSPELLAWYNSIPQGWQMPMANLGGG
                     SMFVAIVTSIIGVEIYRFTDKSKFKITMPEAVPASVTRSFEALTPAALIIILMAIVTY
                     FLGFDWHGFIAKLVTPLVSATDTLPSVIILIFLITFFWSFGIHGVSIIGSLARPLWIQ
                     LLDANTASYAAGQAVPGIAAEPFFQWFIWIGGSGATIGLALLLAFRAKSAYGKSLGKA
                     TVIPAIFNINEPIIFGAPIVLNPILIIPFVVAPIVMATVSWFAMSANLVSRVVVTAPW
                     TLPGPVGAYLATGGDWRASVLNLLCIAISIIIYYPFVKMYDKRLLHEEKVEEQEAY"
     gene            complement(10050..10358)
                     /locus_tag="KRO40_001478"
     CDS             complement(10050..10358)
                     /locus_tag="KRO40_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092300.1"
                     /translation="MRVLFVCSSGMSSAIAVNALQKEGAKNGIDIDVLAVGTQEFENE
                     VKNGWDIAMVAPQVRHRFDYLKAFADEVSVPCALIQAQAYSPLGGPKLLKQVQELLSK
                     "
     gene            complement(10620..11018)
                     /locus_tag="KRO40_001479"
     CDS             complement(10620..11018)
                     /locus_tag="KRO40_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092301.1"
                     /translation="MSNNKKKKRKKNNNYKNAKSTKSNKNTKKQMEKNQRTDYNIPTI
                     SFKSGLILIVSSLVSTVVFPLLLSIFGIDNRFGVVIGNSLITSFAVAYTRYFVETKRG
                     FSLGFFRLYILFALSFAIIGYFWIYKGIHI"
     gene            complement(11020..12180)
                     /locus_tag="KRO40_001480"
     CDS             complement(11020..12180)
                     /locus_tag="KRO40_001480"
                     /EC_number="2.7.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anhydro-N-acetylmuramic acid kinase"
                     /protein_id="HBH2092302.1"
                     /translation="MITMYSVGLMSGTSLDGVDAVLAEISGNGRNTKVKQIEFITLEI
                     PKDIKDEIRKCCIEEESSVDLICSLNFKLGYLFSKAVKSVCHKANFHIANLDFIASHG
                     QTIFHIPRSYNNFVSSTLQIGEPAVIAYETNTKVISNFRVMDIAAGGEGAPLVPYSEF
                     LLYSDNNKNLALQNIGGIGNITIIPKSCNIDDVFAFDTGPGNMIIDGVCQRLFNRKYD
                     KNGYFASKGKINEEMLKDLMSHKYLSQAPPKSTGREVFGQVYLDNMLNKYKHVDKYDL
                     IATVTMFTAKAIYYNYKNFILPKVNVDTLLIGGGGAHNLTLIGYIKELLLEVEVLTQD
                     EYGYSSDAKEALAFVILGNETLNNSFSNVISATGAKNKVILGNITPKPFGGK"
     gene            complement(12611..13630)
                     /locus_tag="KRO40_001481"
     CDS             complement(12611..13630)
                     /locus_tag="KRO40_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092303.1"
                     /translation="MLVKYLKGRSKYIALPLVVVSIINIYLFAIDIFKNKYSELIYLD
                     FLVLFIIMVFFVIDYINFRNSYTNLYNCIENSGEIDSYLVDGQSFEENLIKDIIENLK
                     IKNNSDIETYKQSLKELDEYIAKWVHEIKIPISSLSIITDRLSSIEDSLDIKNQVAKI
                     NFLVNSILYSSRSNTMFEDVFINKFNLEKLVKMSIKNNSFLLIKNNVEVSLNELENDV
                     YTDSKCMSYVLDQIINNAIKYSKEVGKIEFNSKKLENGVVLSIKDFGIGINEEDISRV
                     FDKGFTGKNGRNQLYKSTGMGMYFVKKMIDSLGHEIEVCSENGSYTIFNIYFYDISDY
                     LSLDS"
     gene            complement(13624..14304)
                     /locus_tag="KRO40_001482"
     CDS             complement(13624..14304)
                     /locus_tag="KRO40_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092304.1"
                     /translation="MYRILLVEDDIDLSKEIALALEKWGFKVELIDDFEVVLDEFIDK
                     KPDVVLLDVNLPLYNGFYWCEKIRAISNVPLIFLSSRDSDMDLIMGINNGADDYITKP
                     FSIEILVTKINGIIRRVYNYSDSNSILYCEDLMFDVGKGIIKHKYKDKSIELTKNEIK
                     ILTLLLKNKNRVVSRESLMMTLWDNDEFVTDNALTVNMNRLRSKVKELGFDDFIKTKK
                     GIGYIIQC"
     gene            complement(14456..16359)
                     /locus_tag="KRO40_001483"
                     /pseudo
     CDS             complement(14456..16359)
                     /locus_tag="KRO40_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891367.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(16360..17112)
                     /locus_tag="KRO40_001484"
     CDS             complement(16360..17112)
                     /locus_tag="KRO40_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092305.1"
                     /translation="MKEILKIKNISKDYGIKGFKTNVLKNISLTVNEGDFISIMGPSG
                     AGKTTLLNLMSTLDKQTSGEIILDGINISKVKNNELSKLRREKIGFIFQDYNLLDNMK
                     LMDNIALPLALGKKKSKEIEAKVFSIAKKFGLENHLDKYPYQLSGGQKQRGAAARSLI
                     TNPTVIFADEPTGALDSKSAYELLESLEKINRENNATIIMITHDPLTASYSNEVYMIN
                     DGNIKCKLNKGNSRKEFYGKIMDMLASMGGEM"
     gene            complement(17428..18582)
                     /locus_tag="KRO40_001485"
     CDS             complement(17428..18582)
                     /locus_tag="KRO40_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2092306.1"
                     /translation="MINKAIKFKFIIFYFFSYIIFAFASTKFTPFLSKLGYSAFERGI
                     ILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGIASVIMFSTESATFIIYLLL
                     VALSGGLLNTCCSLYDTWIIGCGDNINNYLSFIKTFGSIGWAIGSMVASYLILRFSYF
                     GLSVAIGLIVVLLIINILLLPDIEKINKKINVTNKDIIELLKDKKYILLVCILFLLYS
                     MVVANNCTVIDKMIALNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSA
                     IMITVQFLLFALTNDSNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIAL
                     SIFMGGSFLIIPTVAGFLSINIGYNYTLMVLSLFGCLAYCLIVLLNYLQE"
     gene            complement(18585..19052)
                     /locus_tag="KRO40_001486"
     CDS             complement(18585..19052)
                     /locus_tag="KRO40_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2092307.1"
                     /translation="MFFKRKKEAITINSYIDGKIINLGEIPDKVFSTKVMGDGFAMIA
                     KDNILKSPTKGVISFIAQTNHAIGIKLQNDVQILIHIGLDSATTKKENFKLEVKQGQE
                     VNMGEKLVEIDNKLLENTLYIPLVIVENPNTVKYHLSNLNQEGNSGIKVINFD"
     gene            complement(19066..19554)
                     /locus_tag="KRO40_001487"
     CDS             complement(19066..19554)
                     /locus_tag="KRO40_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092308.1"
                     /translation="MITNKIKNITAVLKDENIFLSVVMVCFLILPVLYIVYLELTSLF
                     TNISFSQLLNNDVNASLNLISNFSAVYSAYVIYNIKKNKEIKENMIAFYLVLLGQIFQ
                     IYTITIVIMFTYIYKFVGIKQIISSIKELQWGKSYKALFSSIAVCLISLFVMIIRIKL
                     IM"
     gene            complement(19568..20899)
                     /locus_tag="KRO40_001488"
     CDS             complement(19568..20899)
                     /locus_tag="KRO40_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH2092309.1"
                     /translation="MERKRQRILIAGGGSTYTAGIVTMLIESVAKFPIESIKLYDNND
                     ERQRKVAEACAIIVREKNPEIKFSYTTNPEEAFTDIDFVMAQIRVGLYALREQDEKIP
                     LKYGVVGQETCGAGGIAYGLRTIGPIIEMIDYMEKYSPNAWMLNYSNPAAIVAEACRV
                     LRPNSRIINICDMPVCLEEIFARVLGLNSRKDFDVRYYGLNHFGWWTSIKDKEGNDLM
                     PKLQEYCAKKGYEEFTPQGQHKESSWLETMRAAKDLLEIEPTTLPNTYLKYYLMADET
                     VEHANPNYTRANEIMDRREKDTFEECERIIKNGTARDTWFDASEHSQFIVELACALAF
                     NTQERFLLIVPNNGAIENFADDAMVEIPCLVGKDMVEPMSIGKIPTFQKGLMEQQVAS
                     EKLAVEAWIEKSYQKLWQSFTMSKTVPSAKVAKEILDEMIVANKDFWPTFK"
     gene            complement(20913..22478)
                     /locus_tag="KRO40_001489"
     CDS             complement(20913..22478)
                     /locus_tag="KRO40_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003233606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2092310.1"
                     /translation="MMKKIQRFGGAMFTPTLLFAFAGIMVGFSIVFQNQSIMGSPATP
                     ENIWYQFWGVISSGAWMVFNQLPLLFAISLPIALAKKQQARACMEALATYLTFNYFVG
                     SMLSFWGKSFGVDFAAEISAGSGLVSIAGIKTLDTGMVGALLISGIVIYIHNRFYDKE
                     LPDFIGLFRGSSLVVAICFFVMIPVALLTCFIWPHIQNVIRHLQTFFINSGNIGVWCY
                     AFLQKILIPTGLHHFVYAPICYDSVVVPGGTSVYWATHIQDFQTSAKTLKEMYPIGFS
                     LSGLSKVFGSLGVFGAFYVTAKPEKKKKVLGLMIPATLTAVLTGITEPLEFTFLFVAP
                     LLFLVHAFLDACLQTISFALGVVGDFGGGIINWVVLNWLPLGMYHWKVYVVQVVVGII
                     FSFIWFFVFTFLIKKFDMKTPGREEDSEETKLYTKNEYLETKDEKGNKLSKASQQAYE
                     YIKLVGGAENVVDVTNCATRLRLTLKDDSIISKEEDFKAVGAHGLVHNGKAIQIIIGL
                     SVPSVREEFENLL"
     gene            complement(22648..23433)
                     /locus_tag="KRO40_001490"
     CDS             complement(22648..23433)
                     /locus_tag="KRO40_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2092311.1"
                     /translation="MRLEEMIFLNYNKLNDTDLLIWKYITANKKHCSKMSINELAMKC
                     NVSRATITRFVKKLDLKGFSEFKVLLSWESEKVHVIENQSFDIACNSIIKYVEDQKNK
                     DYDALCKLLYESRTIYAYGSGDIQNVVAKQIKRMFLSCQEIIYDFEGRTFDDSFYNIV
                     SKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNI
                     SFLQMHPSYKLTMLYFILIELLFIKYSIYKRHRMITEGIDCKL"
     gene            complement(23600..24799)
                     /locus_tag="KRO40_001491"
     CDS             complement(23600..24799)
                     /locus_tag="KRO40_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S41"
                     /protein_id="HBH2092312.1"
                     /translation="MKKKVLFLVIILAFIILLGNSTYSQKNQLSEEEKVDDFNYVYNV
                     VKTGYPYLGVNKRLNNIDWLANKDEYTKRIKNTENDEEFIEELSSILSDLNNKHTEVI
                     DNKKRYELFKKSYSNNDWYDFLNDKKVVDRYDSMNLKIKMPDDIFVKKELILKDVIKG
                     QIGYMYLPSMSSKNGSINNDLKIIGDYINTLEKHKALIIDIRGNLGGSDRYWQGIVSK
                     LIKNDVKINGYRIYRNNNEIVKKYTNARNIKLNPVENLPASVKENAPKEIIKDFNDFE
                     DTSYTIKSTDDSKFKGNIYLLVDRKIYSSSESFAMFCKENKFATLVGETTGGDGGCID
                     PVLFNLKNSGLIVRMASCMYLNKNGICDEEFKTIPEFKVKDCKRTADFKDDNCIRKAL
                     ELENINY"
     gene            complement(25321..26658)
                     /gene="xylA"
                     /locus_tag="KRO40_001492"
     CDS             complement(25321..26658)
                     /gene="xylA"
                     /locus_tag="KRO40_001492"
                     /EC_number="5.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylose isomerase"
                     /protein_id="HBH2092313.1"
                     /translation="MSEIFKGIGQIKFEGVKSDNELAFRYYNPEQVVGNKTMKEHLRF
                     AMSYWHTLCGEGNDPFGVGTVERPWNNITDPIEIAKIKVDAGFEFMSKMGIEYFCFHD
                     RDIAPEGRDLEETNKILDEIVEYIKVNMEKTGIKLLWGTANMFGNPRFVHGASTTCNA
                     DVYAYAAAQVKKAMEITKYLGGENFVFWGGREGYETLLNTNTELEMDNFARFLQMAVD
                     YAKEIGFSGQFLIEPKPKEPTKHQYDFDTATVLGFLRKYNLDKYFKMNIEANHATLAG
                     HTFQHELNIARINNVLGSIDANQGDLLLGWDTDQFPTNIYDATLAMYEVLKQGGIAPG
                     GFNFDSKVRRASFEVEDLFLAYIAGMDTFAKGLLIAHKLLEDEVFENFTKERYASFSE
                     GIGKDIVEGKVGFKELESYALQMPVIKNKSGRQEMLEAILNRYIYEVDTISNK"
     gene            complement(26754..28304)
                     /gene="xylB"
                     /locus_tag="KRO40_001493"
     CDS             complement(26754..28304)
                     /gene="xylB"
                     /locus_tag="KRO40_001493"
                     /EC_number="2.7.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylulokinase"
                     /protein_id="HBH2092314.1"
                     /translation="MKLEYVLGVDIGTSGTKTVLFDKLGNTIKSCTYEYPLIQEKSGW
                     AEQDANDWWKAVVESIREVVQSSNISSECIKGIGLSGQMHGLVILDNEGKTLRNSIIW
                     CDQRTVKECEEITDLVGEERLIEITANPALTGFTASKILWVRNNEPDIYKNTNKILLP
                     KDYIRYKLTGEYATEVSDASGMQLLDIRKRDWSDEVLEKLNIDKNLLGKVYESQEITG
                     YVTRDVASLTGLKEGTIVVGGAGDQAAGAIGNGIVKDGVVSSTIGTSGVVFAYTKEPK
                     IDKEGRVHTFCHAIPNTWHVMGVTQGAGLSLKWFKDNFCQSEVEVSNSLGEDVYEIIN
                     NQVSKVPTGCNGLLYLPYMMGERTPHLDPYARGVFFGLSPIHSKKEIARSIMEGVSYS
                     LKDCMDIIENLNIDVNEVRASGGGGKSKVWRQMQADMFNQDVYTINSSEGPALGVAIL
                     ALVGAGIYENIQKACDAIIKTSTKLEPISENVDTYNIYHRLYKRIYKSLKDDFKLLDE
                     VVNAKINN"
     gene            28512..29672
                     /locus_tag="KRO40_001494"
     CDS             28512..29672
                     /locus_tag="KRO40_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBH2092315.1"
                     /translation="MVTDKYTIREMNERLVLEQIIKNGPISRASIASTIGLNKATISA
                     ITKKLIDESLVHEIGIGNSTHSGGRKPILLVFNKCAGISLSMDIGYDYIFSSLSYLDG
                     TIINSKKLTDIQVSKDNVIQLIDEIINSYNISKIDTPYKVIGLTLAIHGITCENKVLF
                     TPYYNLNEIDLYSILSKKYDFPIHIENEANLTALAENTFSTVHNSLLSLSIHSGFGSG
                     IIINNKLYSGRNGMSGEIGHTIIMPNGKLCPCGNRGCLEQYCSEKKVFEQLSSLENIP
                     KIDSDIVKQLYYEDNQNAKKVIHEFCSYLTIAINNAITTYAPEIIYLNSQIISDIPEI
                     LQITKDMLVSSFNKGINIEISSLGSEASLYGGSAVNIKSFLNIQNLTLINEI"
     gene            complement(29828..30232)
                     /locus_tag="KRO40_001495"
     CDS             complement(29828..30232)
                     /locus_tag="KRO40_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092316.1"
                     /translation="MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGT
                     IEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANNDSRIKIISGLNLGMVIESAF
                     LDTKELAAKLEKIGKDNISMVEQNASLLSDDE"
     gene            complement(30253..30735)
                     /locus_tag="KRO40_001496"
     CDS             complement(30253..30735)
                     /locus_tag="KRO40_001496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092317.1"
                     /translation="MEMKGIKNIRIDDRLIHGQVATMWSNKLGVTRLMVVNDAVANNS
                     VQKQVLRMATPAGIASSIITEETAIKNITAGKYEGQNVLLIVKSPVDLIPFVEAGFKI
                     HNINVGNMSSRKDTTVLRPNISVTEEEKEAFKRLLDEGIEITTIMTPDDKKTYLVDIL
                     "
     gene            complement(30755..31564)
                     /locus_tag="KRO40_001497"
     CDS             complement(30755..31564)
                     /locus_tag="KRO40_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH2092318.1"
                     /translation="MSDKVSLNKSNEKVKKSVLWRWFFTSSVSSNYEKMQALAYCYAV
                     LPFLKVVYKDNPEKLQSAVLNHLQFFNTNPWVAPYILGINVAMEELSSEETEEAVASI
                     KTGLMGPVAGLGDSLFVVIPWTIFGAIAANMAIDGSPFGILLWIVVSVALKLLSIPLF
                     NAGYTSGTKLISSIEKSLKILTESTSILGLMVVGALIPSVVKANVALNFQQGDFTMKG
                     QEILDQIMPGLVPAILVVIVYWALKKNIKPIYLILGVMVVSIILYALGILK"
     gene            complement(31557..32336)
                     /locus_tag="KRO40_001498"
     CDS             complement(31557..32336)
                     /locus_tag="KRO40_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2092319.1"
                     /translation="MEPQLWQLLLIVLYGFFINYEKNSTMFGTYQPVTAGFITGLILG
                     DINTGLYIGGTLQLLSLGISNFGGASIPDYQTASIVATFITITTKQEASVGISIGIPV
                     ALLMVQLDVLRNTIGIWLVHKAEDGAKKGNYKNITYMQMLGVLLTAATTGIPVALSVI
                     FGPSLINTILKYTPEWLTGGLTVAGGLLPAVGIGLLLRYLPAKEYFSYLVIGFVLAVY
                     MKVPLLGVALIGGAIALIIYKKNLENQEQQYTVVGGMDEDE"
     gene            complement(32336..34414)
                     /locus_tag="KRO40_001499"
     CDS             complement(32336..34414)
                     /locus_tag="KRO40_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase"
                     /protein_id="HBH2092320.1"
                     /translation="MIKISEDYIEKRFDNELLRIEAWGKNSLRIRSFVDQNFVDENYA
                     LNEKPKLNKDDITINKNEDGSAIIKNGKIKAVLDHRDRITFYNDKNEILLKEYIRLRA
                     VKHDDGGEDVGTIEITKDFNSTLKLKSREYRPSYSGEFEVTTRFESEPSEKIFGMGQY
                     QHKFLDLKNTVLELAQRNSQISVPFYISSLGYGLLWNNPGIGKVSFAKNMTEWKMFST
                     NFIDYWITCGESPKELNKNYSQVTGTVPMMPENLLGLWQSKLRYRTSEEVLDVVKEYS
                     KRGIKLSSIAIDYFHWPKQGEYKFDLDYWKNPKELVKKLKEEYSVEPIVSVWPTVQSD
                     AENYNDYLENGYLVNVNRGVRMTMQIQGNTVFVDMTNENAREYVWDRIDKNYKQLGID
                     YYWLDVAEPGYSVYDFDNYRYKKGNVLSCGNIYPIDYLKMIYDGLHNDIESVVTLVRG
                     AWAGAQKYGALVWSGDIDSSFEAFNNQVNTGLNMGLAGIPWWTTDIGGFHGGNPKDPE
                     FRELMVRWFQYATFSPILRMHGDRLPHSKPLSNKGGGSMVTGAPNEIWSYGEEVEVIL
                     TKFIKIRESLKTYLKKLMKEAHEDGTPVMRTLFYEFPEDDKTWEVDNTYMLGDEILVA
                     PIMNYKDRSRKVYLPKGHTWENIFSGVSYEGGKTYEVECPLEEIPIFLKQDSSYNFKE
                     LKNILGEVKS"
     gene            complement(35213..35734)
                     /locus_tag="KRO40_001500"
     CDS             complement(35213..35734)
                     /locus_tag="KRO40_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBH2092321.1"
                     /translation="MKRNREIVVVCHCILNCNSKVEGLSEFKGAQNIAIDLINKGYGI
                     IQLPCPEMIMYGINRWGHVKEQFDNLFFREQCRQMLIPHVRQFDEYLKNDYDIKSIIA
                     IDGSPSCGYNKTCSSKRWFGELSGCNELMDKINDIQMVDGKGIFIEELEKLLKEYNLE
                     IPIVGFDELREDK"
     gene            35900..36466
                     /locus_tag="KRO40_001501"
     CDS             35900..36466
                     /locus_tag="KRO40_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH2092322.1"
                     /translation="MDTKKVTFSSMCIVINIVLGMVISMINIPLLFLDTVGTVLGAVV
                     LGPFWGALIGGCTNLVLGVISGPTNIPFALVNIVLGLIVGYISKKKGFGYKEAIITGV
                     ILSIVCPLIGTPISVLLFGGLSGSGADLLVGFLVQSGQKIFTAAFFPRILSNIVDKPL
                     SCIMVVYFISKMPKGFIKQYSKNTSSSY"
BASE COUNT        12013 a         6377 c         3908 g        14188 t
ORIGIN      
        1 tttaaacaga ataattatac caatatataa aaaaatttct aaaaaacaat aaaattaagt
       61 tataaacacc aatatatttc tattatttca ataagtatac aattagatta gaatctaacg
      121 ctagtaataa aaaattactt tcccaaaata gatataagcc tcattttatc gttcaaataa
      181 tgaaaatata tttgatttca tgcaaaaaga gtgcctaatg aactaaaaag ttcattttga
      241 gacactcatt tttttatata aatttatata gtttttaatc gttcgcattc aaccactcag
      301 ttaagacttt tatatatttc tcattttctt caacgaatgg catatgtctt gaatactcaa
      361 ataattccca cttactatta ggtattctat catacatagt ctttgcaata tatggtgaac
      421 ataaatctat tgctccacta gttactagac aaggctcttt tatttcatgt aatctatctg
      481 taaattcata tccagaaaga gttcctgtag gagaaaattc attttgtccc catcctacaa
      541 tatatgcttc agaacctgat tttttaggtc ttctcaggca ctctggagaa tcttctgtca
      601 cttcacctgc acaatacatt tccataaatc tttctaatgc atcattatat tctttgctag
      661 agtaatctcc agtatttact gcatcaagta atgctttttg gtcaacctca ctcatatatg
      721 atattcttct tttttgttct ttctcccaaa gttttgcaga agaaagagta gatgaaagga
      781 tgtaagactt aatacctttt ggtttatatt caatagcata ccaaatagcc tgcatacctc
      841 cccaagattg acctaacaga tgaatttcat caagtcctag atgttttctt agttcaataa
      901 gctcctctat ccaagtatct gcattaaata gctcaggatg cccttctaca aatgaatttc
      961 cacaaccaat ttggtcatac attattactt gtctaccact ttcagctatc ttatccaata
     1021 cctcaaaata gttgtgtgta gaacctggac ctccatgaag taatactaat ggcttcttcc
     1081 cttccgtatt ttctcctact atacggtaat acgttttaaa acctttaaaa ggcatatatc
     1141 cttcagtaat tttcatgttt atctcctcca atttgtaatt ataaacaata atcaagttca
     1201 ttaacaatac tatttaaaac ctcttataca tatttgatta tgtattttaa tctttatacc
     1261 tacttttata aatagtataa cataaaagtt aaaaatctct atactaaacc aattataaaa
     1321 ttatattaac tatataattt tattttttaa taatagtata tacatatttg attattttca
     1381 tttgctattt aaaatcaatt ttaagttttc ttcttataat aaacttcctc tttgtggtct
     1441 catgttagtc tctaaattta aaattttaca aaaaattttc ataaaataaa attatattga
     1501 ttgtatctaa acaaataggg caataaaata attaagtata gttacttacc tttcaagcaa
     1561 tattagtttt atgttagaat tttattatat tgatttacag gaggtttgca tttgaataat
     1621 attaattcac ttaaagtaat aaaattatct cttggatgtt ctcttgctat atttattgct
     1681 tggctattaa aattagaata ctcaatggtt gctggagtta tagtactact tacagtaaag
     1741 gacactaaaa gagaaactct taaaggctcc attggaaaga tttatggttt tcttttatgt
     1801 actatttttt catatttatg ttttaatatt ttaggatata atttgacttc attttcaata
     1861 tttatattta taattatacc actttgtttt ttgttaaata ttcaagatgt tattgctatg
     1921 tgtgtagtca tagcatccca ttactacctt caaggagaaa cttctatcaa atggatttta
     1981 aatgaagctg gaatatttgc agtaggaact ggaataggtg tcttaataaa tatgtatatt
     2041 ccaacaaata tacataaaat ccatgaagtt caaaaaaagt tacaggaaga agtgagtatt
     2101 gtacttatag acattgcaga tattattgta aatcctaaaa aagaaaatgg atatagtaga
     2161 gatttatata cattaaattc acttattgac agcagtattt ctgaaactta cgataatatt
     2221 aataatactt tattaagtga tactagattc ttcttagagc atatggatat tataaaaagc
     2281 caacgggata tcttagaaaa tttgtatagt tatgtatctc aactaaattc tacaccacca
     2341 caagctcata ttctatctgc ttttatacat aagataggtt atactgaatt tgaagctgaa
     2401 acaggcaatc ttcttcttga agaattaaag agactaatga ttagtatgaa aaaccagcct
     2461 ctacctgttg acagaacaga gtttgaaaat agagctattt tattcctatg cttgactgag
     2521 ttaaaacagt ttttagttaa tcgtaaacat gctcagatgc ttagagataa taatttttat
     2581 aaataaaaag gggagaaatc tagcagttga cctgactaca aaatatcaga tataatatta
     2641 aatgcgcccc tagtaagagg gcgcaatgtt tataacttat tctactgtca tgattaaatc
     2701 attattcata tcgaacatac attatttgac caagtccaat attagctttt tcatcagtga
     2761 tttctatttt aatagtcaca tcattttttt tacagtactt cgctaattct gcaccagaac
     2821 gatttttacc actaaaatct aaagaaaatg gcttatcata tttaaaagga tattcaacag
     2881 gtttaccctc tggtgctaat gcaaacatcc catatggtgt gttcataaat cctattacag
     2941 caatcgtaag atttgatggg tctaaatttg attcactacc tgtaaatgta attgtattta
     3001 ctgatgaatt aactacacta catctaacac cttcatacat tacatgtttt tcatttatat
     3061 cttctccttt ttttccaaaa tttgcaacag cctttgcccc ttcttgatgt ggtaacatag
     3121 tgtgcttccc aggtggtgct ggtttctgtg tctgttctgg ttttaccgtc tgtactattg
     3181 caccaacttt tggatatgct gtcttatcaa atggtaatgg gtggctaaga ctcttgtata
     3241 tgatatcctt tcctgctgat ttattagcat caatatctac atgatacaaa cgcccatcac
     3301 caaaacggat aagattccac tggtggtcat ttgatgtgct gtgtacataa taagattcaa
     3361 ttcccatagc atcacacaaa gctttcatgc tcctagccat tcctgagcat gcaccttttt
     3421 tagtaaccaa tgtataggca gtatttgctc cctctactgc attccagtca acatatgttg
     3481 tgttattttt aatgtgattg taggcaacta aaatcttagc atctgtggtc atattctttg
     3541 tgattttctt gttcataaaa tctgctgttg cttgtgctac tgagtttagt tgggcttgtg
     3601 acagctttgg accatatacg ctattggttc cagtgacata gctttttggt gtttttgctg
     3661 ttacctcttt ggctgtcata ccataaactg tcatactcat acctgagatt aaaactattg
     3721 ttgtaatcaa taacttggta gctaacttcc taattttctt catacttaat attctccttt
     3781 ataaaacatt gttacttcct attctctacc attaataaaa ttaatttagg atttaaaaag
     3841 gtggattgtc aacatgtata tttctccatt catacattcg tgaaatattt aaatttcatg
     3901 gaaaatctaa tagatatttt ctagataatt tgtatacaat acaactcgca aatcagggtg
     3961 tttgctgtta gtttgagaaa atgatgatga ttaatacatt cggaatcttt gacctataat
     4021 aaataccatt gtcttcaatc attaataatg gtaagagtaa agagaattat caataataca
     4081 gttaaaatca actttgtata catttcatac attctctccc aacaacatta tacttcttat
     4141 aatttgtata ttcaatacgt tttctgggaa aatatagata tatctataaa aatataaaaa
     4201 aggagttgaa cttaaaattt gattaaaaaa aatcaatttt aagacaactc atttgtatta
     4261 taaaaatgct atatattatt attaagtaag tcaatatttt agatatttat ctatttctta
     4321 ttgacttacg cttatagtct aacttatttg tttagttgat atataaccta gttttaagca
     4381 ttattaatat ttaaataatc aagtatcctt tttgtttctt gtagtttctg ttctgcctca
     4441 tttaagtttt cttgaattat agaaatatat attatatcta tcaacgtaag cattgctatt
     4501 cttgaagaaa tagctccttc tctaagtctt ttttctatat ttggtactac tagctttaaa
     4561 tcactaatct tactaagatg attgtcacta tatttagtta tacaaatgac cttacatcct
     4621 tttaattttg cattttctat agactttatt acttcttttg attctccaga gtaagatatt
     4681 gctatagcta tatcttcttt atctacattt gaagatacca taagttgtgt atgactatct
     4741 aaagaggtaa atgcctgttt atttatcctt aaaagtttca tctgtaaatc tagtgcaact
     4801 aaagccgaac cacctactcc aaatatatat acatttttag cctttattat ctgttcaact
     4861 gcttctttta ttatatcttt ttcattcaac aaccttgttt ggttgatagt ctctatgttt
     4921 ttgtttgtaa ttttgtttat aacactatct atattacaat catagttttc atctacatat
     4981 gtgtattcat tttctttgcc catcaaatct ttagctatct caatttttaa atccccaaaa
     5041 cccgaatatc ccatttttct agaaaaccta actatacttg ctgtacttgt ttttgagttt
     5101 gacgccaatt ctgatacaga aagcttactt atagcctctg tattattaag tatgtaatca
     5161 gctatttttt tatctacttc cgttaaatct tcatatatct gttttaattt taaaatgcaa
     5221 ctcatactct accacctcta cctatttact ataatatttc ttcttagcaa gtaaacatgc
     5281 tcctaaatct ggagtcaaca ctggtctcac tataccaaat ctcgttttat tcaaatattt
     5341 tttaagtggc tctaatatta aatctcctga cttaaacact ccacctgaat aagatacctt
     5401 tatctttgta ccttgttcaa aatgatgctc taatcctatt ataagcctac ttaattcata
     5461 agctgcatca tcaaatattt tactagcagt attatcacct tcaataactg cttttaaaca
     5521 tatcgtagca aactttgcta tttctattct atctccttgt atttcatcat ttacatattt
     5581 tattatgtca taatcattct ctatattaag atgtcttttt attaaatcat ataattttgt
     5641 ttttgaacac cttccatcag actgcattgt gaacattttt aaggtagcca ttcctatata
     5701 atacgctgaa ccttcatctc ctaatacata gccccatcct ccacatctgt gaagattccc
     5761 atctttatct aaagcctgtg ctattgaacc agtacctgca attatattta tacctttttc
     5821 cccatttaaa gaacctgcta atgctatttc tacatcatta cctagagtat aatttatatg
     5881 actatatgca ttttttgttg ctacttctaa tgcatacaat acttctttta tttttccata
     5941 tccagcaagt ccaacaaatg catacgttat ttcttctaca tttatcttag catctttaca
     6001 aacttcttcc aacccagtta ttaataattt cgttagatta tcaaatccta tttgattata
     6061 atgacaggtt cctttggtta tggttcctac tatatttaat tcttcatcta ctaatgtaaa
     6121 tgttgttttc gttcctccac catctacacc taaaaaatac atactatcct cctacaatat
     6181 ctttaataat tctttcaata cttaatatct aaaaataacc ttccaatgct gtttttttaa
     6241 tattgaaagg ttatcagtac tattatttat tttacaattt ttctattgat tttaaagctt
     6301 cacttatata accttcttgt ctatctagga tactctttgc actatcctta tctaaaccac
     6361 tttttatcat aaatatagcc aatttaacgc tattatctgc ttcttctaag aatttttctg
     6421 caacatcata ttttacattt gtagctatca ttattattct ttttgctctt tcaaccaact
     6481 tttcatttga tgtcttaaca tctaccatca agtttgagta tacttttccc atcttaacca
     6541 tagaagctgt tgttaacata ttacatacca ttttttgagc tgtaccactt ttcattctag
     6601 ttgagcccat tattacttct gcccctacta taatgtttat tggtaaatcc gcttttttac
     6661 tcatttcact attcggattc atagttattg atagtactgc acaccccaat tccttagcat
     6721 actccattgc acctataaca taaggagtcc ttcctgatgc agctatacca catataacat
     6781 ccttagatgt aactcctcta tctattatat cttgctttcc aagttcttta tcatcttcag
     6841 caccttctat tgctttaaat attgcttgat ttccaccagc tattatagct tgaacaagct
     6901 caaaatccac tccgtaagtt ggaggacatt ctgtggcatc tagtattcct atcctaccac
     6961 tggtacctgc tcctatatag aataatctac ctccctgttt cattctatct actattatat
     7021 taacagcttt tgctatactc tccttttgtt cttcaacagc ataggctaca gttttatctt
     7081 cgttatttat taattctatt atgcctaatg tatcttcttt atctatttgc aatgtattct
     7141 tatttctacc ttctgtaact aaattttcta aagtttttat taacatatca tttcctcatt
     7201 ttcttaatat taaattttta aacacatttt aattccaact ttcataatta tatttttata
     7261 ataaattaat attttcataa taaattattt tgttgagggt ttaaaattaa acttttgcca
     7321 tggtttaata taatctaata taaataattc ttcttttctt atatatccta ctacattcga
     7381 tttaccactg tttttcatat cagtcaaggc tatttgtaac tcccctgcat aatgaccata
     7441 ttcactactt tcaattacta tatctcctct ttttattatt ttaggagtat taaatagttc
     7501 aaatttgtat cctttatatt taacacgaga ttgagtagac cttatcagac tgtcagatat
     7561 gtcccctcta ttaaaatgta tttcttcaaa gagtatcttc ttctcaactt ctcgtatatt
     7621 ttcctctatt gctacatcaa atgtaaccat atcttttctc atagaaccta atacctttag
     7681 ctcctcatat gttggataac aatttgatat tattatatca tttatattat tcatagctat
     7741 tatatgcttt acttgaatat ctataggtag atttctgtgc atctcaattg ttggaagccc
     7801 atcagttaca ggccatggtc caaatgtagt ttcattttga cttgttacaa aaactgctgt
     7861 tcttaatcca tacttattaa atctttctgt acattttata aagtgttcta aatttaatcc
     7921 actatatcta tgtggataaa agttatgaca tcctatcaaa ttttctttat ttggttggta
     7981 gtccattatt gtatctatat aattagtatt attactcata ttgatttcta ttttaagatt
     8041 ttgaggatta aaagtcatta atgcctcttc agaacctgta aatcccatat caagccttat
     8101 tccgtctgcc ttcgtctttt taaaaaaatt caaatctttg tagcttattt ctaattcacc
     8161 aaatactctg ggatttacat caagtattac ctcaaaacct ttaaacttag cgtattcatt
     8221 tatactttta aattttttaa ttatattttc tttagtatct ttaactgata ataaacatga
     8281 aaatatacgt gtaaatccat tttcagcagc tttatctata taatcatata tttccttaga
     8341 tgttgttttt tctggataaa ttgatattcc taatcttccc atctgtgtca tctccttata
     8401 tcctatatgt gtttaaattt atttcgaatt acacgaaact tttttaaaaa tttgatgaaa
     8461 aaaagtttca tatatattta taaaaaaaga aaagtttacc ttttcttttt ttataaacaa
     8521 tcaacaaaat atcttcgtta cttatttcat aactgttata ctttgaaatt tatactaatc
     8581 taatatagtt tttaatttcc aatatagttt ctaattaata agcttcttgc tcttcaactt
     8641 tttcttcatg aagcaacctc ttatcgtaca tcttgacaaa tggatagtaa attattattg
     8701 atatagctat acataataag ttaagaactg aagctctcca atctccacca gtggctaaat
     8761 atgcccctac tggtcctggt aatgtccaag gagcagtaac tactactctg gatactaaat
     8821 tagcactcat agcaaaccat gaaactgttg ccattactat tggtgccaca acaaatggta
     8881 ttattaatat tgggtttaat actattggtg ctccaaatat tattggttca tttatattga
     8941 atattgctgg tattacagtt gcttttccta aagactttcc ataagctgat tttgctctaa
     9001 atgcaagaag taaagctaag cctattgtag ctccagaacc tccaatccat ataaaccatt
     9061 gaaaaaaggg ttcagcagca atacctggaa ctgcttgacc cgcagcatat gaagctgtat
     9121 tagcatctaa taattgtatc cataaaggtc ttgccaatga acctattatt gatacaccat
     9181 gtattccaaa tgaccaaaaa aacgttatta aaaatattag tataattact gatggtaatg
     9241 tgtcagtggc tgaaactaat ggagttacta atttagctat gaagccatgc caatcaaacc
     9301 ctaggaaata agtaacaata gccattaaaa ttattattaa tgcggctggt gtcagagctt
     9361 caaaagacct tgtgactgat gctggaactg cttctggcat ggttatcttg aatttagatt
     9421 tgtcagtaaa tctataaatc tcaacaccta ttatagatgt tacaatagca acaaacattg
     9481 aacctccacc aagattagcc attggcattt gccatccttg aggaattgaa ttataccaag
     9541 ctaaaagttc tggactcttt tcaactatct ttaataaatc aggggtaaga ccctctattg
     9601 cagtaggaac tattgtcaaa aggaatgtag ctgtagctaa taaacctcct gtcaatccat
     9661 ctaacttata tgactttgcc aaactataac ctatgccaaa tgtagaatat actgatataa
     9721 taaaaaatgt cattctatat ggtagtaata ttgtaactgc attttccttt agatactgag
     9781 ttacccccca tgaatctggt aatggaggaa atgctaatat caagaaaaat gacccaacta
     9841 ttataagtgg taatgaagct acgattccat ctcttacagc tcttaagtga cgttgttctg
     9901 ccaatctggc catagaagtt gataatttag tgtctaaaaa ttctgtaaat ttatctagca
     9961 tcttttctct ccttaattaa tatttatttt tattatcatt aaaattttta taaaatcaac
    10021 tttcttctaa tctaacaaca ctgcaactac tatttactca acagttcttg aacttgtttt
    10081 aataactttg gtcctcctaa tggactataa gcttgtgctt gtattaatgc acatggtaca
    10141 ctaacctcat cagcaaaagc ttttaaatag tcaaatctat gtctgacttg tggagctacc
    10201 atagcaatat cccatccatt tttaacttca ttctcaaact cttgagtacc aacagccaaa
    10261 acatctatat ctattccatt ttttgctcct tctttttgta atgcattaac tgctatagca
    10321 cttgacatcc ctgatgaaca aacaaataat actctcatat tgattccccc tgttttttta
    10381 tttcttttca atcattatag catgtatttt tgattacagg aatacgtttg tatatatttt
    10441 ttcatatttt acattttaaa ttgtaatttt atttcatgta tttatatctt gctttaattg
    10501 ctttatttat ctaatcattc ttttgtctaa aattacacac tacttaaaat actcatatct
    10561 tttcttaaaa aagaaaaaag actatcttat tattaacata aaatagtctc aatacttttt
    10621 taaatatgta ttcctttata tatccagaag taacctatta ttgcaaatga taaagcaaat
    10681 aaaatataca gtctaaaaaa tcccaaagaa aaacctctct tagtttcaac aaagtatctt
    10741 gtatatgcaa ctgcaaaaga tgtaattaat gaatttccta taacaactcc aaatctatta
    10801 tctattccaa atatagataa taacaaagga aaaactacag tacttactag agatgaaact
    10861 attaatatta atccactttt aaaacttata gttggaatat tataatctgt tctttgattt
    10921 ttctccattt gtttcttagt atttttatta ctttttgtac tttttgcatt tttataatta
    10981 ttatttttct ttcttttctt ttttttatta ttagacatgt catttacctc caaaaggttt
    11041 aggtgttata ttccctaaaa taactttatt tttagcccct gttgcagata ttacattaga
    11101 aaaagaatta tttaatgttt cattgcccaa gattacaaat gccaaagcct cctttgcatc
    11161 agaagaatac ccatattcat cttgagttaa tacttcaacc tctaataata actcttttat
    11221 atatcctatt aaagttagat tatgagctcc tccacctcca attaataaag tatctacatt
    11281 aacctttgga agtatgaagt ttttataatt ataatatata gcttttgccg taaacatagt
    11341 tactgttgct atcaaatcat atttatctac atgtttatat ttgttaagca tgttatccaa
    11401 ataaacttgt ccaaatacct ctcttccagt gcttttaggt ggcgcttgac taagatactt
    11461 atgactcatc aaatctttta acatttcttc attaatttta ccttttgatg caaagtatcc
    11521 atttttatca tactttctat taaataatct ttgacatact ccatctatta tcatatttcc
    11581 tggtcctgta tcaaatgcaa atacatcatc tatgttacat gatttaggta ttatagtaat
    11641 atttcctatt ccaccaatat tttgaagtgc taaattttta ttgttatcac tatataataa
    11701 aaattcacta tatggtacta atggagcacc ttctccacct gctgctatat ccattactct
    11761 aaaattagat attacctttg tatttgtttc atatgctata actgctggtt cacctatttg
    11821 aagcgttgaa gatacaaaat tattataact tcttggtata tgaaagattg tttgaccatg
    11881 agatgcgata aaatccaaat ttgctatatg aaagtttgct ttatgacaca ctgattttac
    11941 agctttacta aataaatatc caagcttaaa atttaagcta cagattaaat caacactcga
    12001 ttcctcttct atacagcact ttcttatttc gtcttttata tctttaggaa tttctagagt
    12061 tataaattct atttgcttaa ctttagtatt tctaccattc ccactaattt cagctagtac
    12121 tgcatcaact ccatctaagg aagttcctga cattaaacct acactataca tagttatcat
    12181 ccttttaagt ttatagttat tcctccccaa atcaaggtat taagtttaat aattttagaa
    12241 ttaatcttat ttcatcttta attacgataa tttactctta tgaaattaat tgagttaatc
    12301 ttatacacgt tttttacctt agctaaatct tacattaatt tattttcagt gtcaatgtaa
    12361 tactatgtaa ttttttttca caaacaaaac atattctctc tccaaaaacc atattaaaat
    12421 agttactaca aataaaaaac ataccaggta catatctgat atgtttttca tatataataa
    12481 ttattatttt ataatataga tagaacatca tttaaggcac taattaaatc ttcactattt
    12541 tcaagaacta aatttattct tattgtatat gtcgatttgt atatgatgat agattttata
    12601 gtctaataac ctaactatct aggcttaaat aatctgatat atcataaaaa tagatattaa
    12661 aaattgtata tgaaccattt tccgaacata cctcaatctc atgccctaaa ctatctatca
    12721 ttttctttac aaaatacatc cccattccag tagacttata caattgattt cttccatttt
    12781 tccccgtaaa tcccttgtca aaaaccctag atatatcttc ctcatttata cctataccaa
    12841 aatcttttat agataatacc actccatttt ctaacttttt tgaattaaat tcaatcttac
    12901 caacttcctt tgaatacttt atagcattat taataatttg gtctaaaaca tatgacatgc
    12961 atttagaatc tgtgtaaaca tcattttcta attcattcaa actaacttct acattatttt
    13021 ttataagcaa aaatgaatta ttttttatag acatttttac caatttttct aaattaaatt
    13081 tatttataaa tacatcttca aacatagtgt tgcttctact actatacaaa atagagttta
    13141 ctaaaaaatt tatctttgca acctgattct taatatccaa actatcttct atgctactta
    13201 acctatctgt aattatactt aaagaagata ttggaatttt tatttcatga acccatttag
    13261 ctatgtactc atccaattct tttaatgatt gtttataagt ctctatgtca ctattatttt
    13321 ttatttttaa gttttctata atatctttta ttagattttc ttcaaaagat tgtccatcaa
    13381 ctaaataact gtctatttca ccactatttt ctatacaatt atataaattt gtgtaactat
    13441 ttctaaaatt tatataatct ataacaaaaa ataccattat tataaacagc actaaaaaat
    13501 ctaaatatat taactctgaa tatttatttt taaaaatatc tatagcaaat aagtagatat
    13561 ttattatact aactacaact aaaggtagag caatatactt agacctacct ttcaaatatt
    13621 ttactagcat tgtattatat atcctatccc cttcttagtt tttataaaat catcaaaacc
    13681 tagttcttta actttacttc tcaatctatt catatttaca gtaagtgcat tgtctgtcac
    13741 aaactcatca ttatcccata gagtcatcat aagactttcc cttgatacaa ccctattctt
    13801 attttttaat aataatgtta aaatttttat ttcgttttta gtcaactcta tacttttatc
    13861 cttatactta tgttttataa tccctttccc cacatcaaac atcaaatctt cacaatacaa
    13921 aatactatta gaatcactat aattatagac tcttcttatt ataccattta ttttggtaac
    13981 caatatttct atagaaaatg gtttggtaat gtaatcatct gctccattat ttatacccat
    14041 tattaaatcc atatcagaat ctcttgatga taaaaatatt aatggtacat ttgaaatagc
    14101 tcttattttt tcgcaccagt aaaatccatt atataatggt aaatttacat ctaaaagtac
    14161 tacatctggt tttttatcta taaattcatc taatactacc tcaaaatcat caattaattc
    14221 tactttaaat ccccattttt caagtgctaa tgcaatctct tttgataaat caatatcgtc
    14281 ctctactaat aaaattctat acatttgtat attctccatt atcctaatat ttcactatgc
    14341 tatgaattat taatatcata acatatttta tatgaattta ttacccaaat tatttagtta
    14401 atcaacaagg agactcttat tacaagaatc tcctttctct ttattaatat atcaactaat
    14461 ttttatacac tacactctta aacttattaa cagatactgc tccatatatt atgaatatta
    14521 tcaaacatat cactaaactt agtatatata taccaaataa atcggtcatc aataaatctc
    14581 ctgctaatct caatgcaaaa taactagata tagttgcact taacattggc aaagtataaa
    14641 aaatagctac ttctttaagt atagctctat ttatatcttt ttctgtagta cctattttta
    14701 acaaaatctt atatttctct ttatcttcat atgcatcact atatattttc atatatatta
    14761 tacttccagc tacaattgca aagactaaga ataaaaacac actacatatg caaacttcat
    14821 ccattgactc tcaccttgag ctttatatcc attttgaata tacacatttt ttaaacttaa
    14881 attcttttca atattgttga acattacttg actattttct tcttgaaata cctttgcacc
    14941 ataaaaatac acttgttgac ccttatctct tagtttaaaa tatgtatcat catttaccac
    15001 tataatactt tgattaagtc ctgtccctag tactggaact tttacttctc cccttgaaat
    15061 attatataac tgaccatcaa gttttatctt ggcttctttt gtagctattg atgctatcgt
    15121 ttgagggctt tttaactcta ttacattatt tccactaact aatctttcac catactcttt
    15181 taattcttta tcattgccat tcactttaag agtattacaa aaatcactat atttcattat
    15241 agtatctgtt gtatcataag cttcttttat atctgttttc tttaaaattg ttagttctgg
    15301 atttactgag tactttatct tattagtatc ttttattata ttctctattt gttttttatt
    15361 cacttcatct ttatccattg aaactatgct aatagtgtac acatttcttt gttcttgggc
    15421 attcttatgt atacgcttca tcgcaactga agcaccaaga gttgatattg ttgtagttat
    15481 aattatagct attatagcat aagttttata gtttttattt aatcggtagt ttatattgtt
    15541 tattgcaatt atattatttc cattaaataa tattttttta tttttgatta taatatcaaa
    15601 tataacaggc ataactgatt tgaataatcc ataagtacct actattatta tacctataac
    15661 aggtagtaca ctagttatat ctccagttct tatattggta gaaagatagt agccatatcc
    15721 tattactata attgatacta tagctaatat atatatacct attcctacct ttggtatttt
    15781 ttcttgtttt ttagatatat tgattagatt tattacacta cttctacata ttgttataaa
    15841 accttttaca gccattatta taaatataga aataaagatt aaagtagcat atagtatagc
    15901 ttctatacta agtccattag atacctttat attaaatcca gataacttta ttatcactac
    15961 ttgaaaaaat ctagatgtta ttatccctat aattattcct gttatacaag aacttattcc
    16021 tataagcata ttttctataa aatatatttt tcctatagta tataaatcta atcccataaa
    16081 agacaatatt ccaatttctt tagacctatt cttaaaaaat atatttgttg cataccatat
    16141 aaagaaaaat aaaaatactg atagtatcat tattacagct actaacactg atagtgtaaa
    16201 ttttttattt tcatcttgta acacatttat agcatcacca tatcttaata attcaaaatt
    16261 agttagcaca actactgaaa aaaccataga tataaaaaat gctagataag ttcttatgtt
    16321 actcttaaaa ttattataag caattccaag tatactcact tacatctcac ctcccataga
    16381 ggctagcata tccataattt ttccataaaa ttcttttcta ctatttcctt tgtttaattt
    16441 acactttata tttccatcat ttatcatata tacttcattt gaataacttg ctgttagagg
    16501 gtcatgtgta atcattataa tagtagcgtt attttctctg tttatttttt ctaatgattc
    16561 taaaagttca tatgctgatt tagagtctaa agcaccagtt ggctcatcag caaatatgac
    16621 tgttggattt gtaattaatg acctagctgc tgcgcctctt tgtttttgtc ctcctgataa
    16681 ctgatatgga tatttatcta aatgattttc taatccaaat tttttagcta tagaaaatac
    16741 cttagcttct atctccttac ttttcttttt tcctaatgct agaggaagtg ctatattgtc
    16801 cattagtttc atattgtcta atagattata gtcttgaaat ataaacccta ttttttctct
    16861 tcttaatttt gatagttcat tattttttac ttttgatata ttaattccat ctagtattat
    16921 ttctcctgaa gtttgtttgt caagtgtaga cattaaattt agcaatgttg tctttcctgc
    16981 accagatgga cccattattg atataaaatc accttcattg actgtaagag atatattttt
    17041 taacacattt gttttaaatc cttttattcc ataatctttt gatatatttt ttatttttaa
    17101 tatttctttc ataataatag cctccagttg ctaatttttt aatatatatt tattttaaag
    17161 gttttatata aataaatcct taagtaaata ttacatttta actgttagca ttacactttt
    17221 gtaacatatg gaagactatt ataattatag tagaaatatc ttaaaataaa aacttgcttc
    17281 acttttttgt ataaacaaag aaaagaagct cctaagaagc ctctaatcta tacaataatt
    17341 cttctctata aaaaaccaaa atacacattg attgtggcaa atacagatac tataaacaag
    17401 tgatattact actatatatt aaaacaatta ttcctgaaga taattcaata agactatcaa
    17461 gcaataagct aagcatccaa aaagacttaa taccattaat gtataattat acccaatatt
    17521 aatgctcaaa aaaccagcaa cagttggaat aatcagaaat gaacctccca taaatatact
    17581 taaagctatt aattggctac tacttctaag ttttttagga gaaacttcaa atattaatct
    17641 ttttgaagta attaaaatta aaggagtaga aaacacttga aaaacacaca gtataataat
    17701 gatatttgaa tcatttgtta aagcaaataa tagaaactga actgttatca taatagcact
    17761 taattttaat aagtttaaac tgctatattt ttttaataaa taagaaccag ccagatatgt
    17821 tggtatctct aacaatgact gtaaagacca ctttaaagat atctgagaat ttgtagcatt
    17881 taaagctatc attttatcta ttacagtaca gttatttgct accaccattg agtataataa
    17941 gaataaaata catactagta agatatattt tttatctttt aataattcaa taatatcttt
    18001 attagttaca tttattttct tattaatctt ttcaatatca ggtaataata gtatatttat
    18061 aataagtaat actacaatta aaccaatcgc tacagataat ccaaaatatg agaatctaag
    18121 aatcaagtaa gatgctacca tacttccaat agcccatcca atcgacccaa aagtcttaat
    18181 aaatgacaaa taattattaa tattatctcc acaacctatt atccatgtat catataaact
    18241 acagcaagta tttaataatc ctcctgataa agcaacaagt aataagtata ttataaaagt
    18301 tgcagattca gtagaaaaca taataactga tgcaattcca taaactgata aactaattaa
    18361 aacaattttt ttcattgttt gatacttatc agctaatact ccaaataata attgaaacaa
    18421 tatattggtt attgcatagc tcgataatat aattcctctt tcaaacgctg agtaacctaa
    18481 ttttgataag aaaggtgtga attttgttga agcaaaggca aaaataatat atgagaaaaa
    18541 atagaatatg ataaatttaa atttaatcgc tttattaatc ataatcaatc aaaattgata
    18601 actttaatac cactatttcc ttcctgattt aagtttgaaa gatgatattt taccgtatta
    18661 ggattctcta caataactaa aggaatatat aaagtatttt caagtaactt attatcaatt
    18721 tctactaact tttcccccat attaacttct tgaccttgtt taacttctaa tttaaagttt
    18781 tctttttttg ttgttgcact atccaatcca atatgaataa gaatttgaac atcattttgc
    18841 aatttaattc ctatagcatg gttagtttga gcaataaaac ttattactcc tttagtcggt
    18901 gatttaagaa tattgtcctt tgctatcata gcaaatccat ctcccattac cttagttgaa
    18961 aatactttat caggaatttc tccaagatta attatttttc catcaatgta tgaattaatt
    19021 gtaattgctt ctttttttct tttaaagaac attatagaca ctcctctaca taattaactt
    19081 tattctaatt atcattacaa ataacgatat taagcatact gcaattgagg aaaaaagagc
    19141 cttatagctc tttccccatt gtagttcttt aatactgctt atgatttgtt taattccaac
    19201 aaatttataa atataggtaa acatgataac aatagttatt gtgtaaattt ggaatatctg
    19261 ccctaataag actaaataga aagcaatcat gttttctttt atctctttat tcttttttat
    19321 attgtaaata acatatgcac tgtatactgc actaaagtta gagattaaat ttaaacttgc
    19381 attaacatca ttgtttaaaa gttgtgaaaa tgaaatattt gtaaataatg atgtcaattc
    19441 taaatacact atatataaaa caggtaatat tagaaaacaa accataacca ctgaaagaaa
    19501 tatattttca tcttttaata ctgctgtgat attttttatt ttatttgtta tcatgttttt
    19561 gttctcctta tttaaaagtt ggccagaaat ccttattagc cacaatcatt tcatctaaga
    19621 tttcttttgc tacttttgca cttggaacag ttttactcat agtaaacgac tgccataatt
    19681 tttgataact tttttctatc catgcttcta cagctaattt ttcagaagca acttgttgtt
    19741 ccattaaacc tttttggaaa gttggaattt tacctataga cataggttca accatatctt
    19801 ttccaacaag gcaaggaatt tcaaccattg catcatctgc aaaattttca atagctccat
    19861 tattaggaac aatcagtaaa aatctttcct gagtattaaa tgctaatgca caagctaatt
    19921 caacaataaa ttgagaatgc tcacttgcat caaaccatgt atcccttgct gtgccatttt
    19981 ttataattct ttcacattct tcgaatgtat ccttttctct tctatccata atttcatttg
    20041 ctcttgtata atttggatta gcatgttcaa cagtttcatc agccattaaa taatatttta
    20101 aataagtatt aggtaatgta gtcggttcta tttccaataa atcctttgct gctctcatag
    20161 tttctaacca actagattct ttgtgttgac cttgaggtgt aaattcctca tatccttttt
    20221 tagcacaata ttcttgtaat ttaggcatta aatcatttcc ttctttgtcc ttaatacttg
    20281 tccaccaccc gaaatgattc aatccataat atctaacatc aaagtcttta cgagaattta
    20341 aacctaaaac tctagcaaat atttcctcta aacatactgg catatcacaa atattaataa
    20401 ttcttgaatt tggtcttaat acacgacatg cttctgcaac tatagctgct ggatttgaat
    20461 aattaagcat ccaagcattt ggagaatatt tttccatata atcaatcatt tcgattattg
    20521 gacctattgt tcttaatcca taggcaattc cacctgcccc acaagtttct tgaccaacaa
    20581 ccccatattt tagtggaatt ttttcatctt gttcacgtaa agcatataaa ccaacacgaa
    20641 tttgtgccat tacaaaatca atatcagtaa atgcttcttc tggatttgtt gtataactaa
    20701 atttaatttc tggatttttc tctctaacaa ttattgcaca tgcttcagca acttttcttt
    20761 gtctctcatc attattatca tataatttaa ttgattcaat aggaaattta gcaacacttt
    20821 caattaacat tgttacaatt ccagcagtat aagtactacc cccaccagca attagtatcc
    20881 tctgtctttt tctttccatc tttccttctc ctttataata aattttcaaa ttcttctctt
    20941 acacttggta ctgaaagccc aataataatc tgaatagctt ttccattatg cactaaacca
    21001 tgtgcaccta ctgccttaaa atcttcttct ttagaaataa ttgagtcatc tttcaaggtt
    21061 aatctcaatc tcgtagcaca gtttgtaaca tctacaacat tttctgctcc accaactaat
    21121 tttatgtatt catatgcttg ttgagaggct ttactcaatt tatttccttt ttcatctttc
    21181 gtttctaaat attcattttt agtatatagt tttgtttctt cactatcttc ttctctacca
    21241 ggagttttca tatcaaactt cttaattaag aaagtaaata caaagaacca gataaatgaa
    21301 aatataatcc ctacaacaac ttgaacaaca tataccttcc agtgatacat tccaagagga
    21361 agccaattta atacaaccca gttaataatt cctccaccaa aatcaccaac aactcctaag
    21421 gcaaacgaaa tcgtttgcaa gcatgcatct aaaaatgcat gtactaggaa taaaagtggt
    21481 gctacaaata aaaatgtaaa ttctaacggc tcagtaattc cagttaatac tgcagtaaga
    21541 gtagcaggaa tcattaaacc taatactttt ttcttttttt ctggctttgc agttacatag
    21601 aaagcaccaa atacacctaa tgaaccaaac accttcgata atccggataa tgaaaatccg
    21661 attggataca tttcctttag agtcttagct gaagtttgaa aatcctgaat atgagtagcc
    21721 caatatactg atgtaccacc tggaacaaca acactatcat aacaaattgg tgcatataca
    21781 aaatgatgta atccagttgg tattaaaatc ttttgtaaga atgcataaca ccaaactcct
    21841 atatttccac tatttataaa aaacgtttgc aaatgtctaa taacattttg aatatgaggc
    21901 caaataaaac aagttaataa tgcaactggt atcataacaa agaaacaaat tgcaactaca
    21961 agtgatgagc ctctaaataa tccaataaaa tctggcagtt ctttatcata aaatctatta
    22021 tgaatataaa tgacaatacc tgatattaac aaagcaccaa ccataccagt atctaatgtt
    22081 ttaataccag caatgcttac aagtccactt ccagcactta tttcagctgc gaaatcaact
    22141 ccaaagcttt ttccccaaaa acttaacata gaacctacaa aataattaaa agtcaaatac
    22201 gttgctaaag cctccataca agctcttgct tgttgctttt ttgcaagtgc tattggtaaa
    22261 gaaatagcaa ataataatgg caattgatta aataccatcc aagctccact agatattaca
    22321 ccccaaaatt ggtaccaaat attttctggt gtagcaggtg aacccataat tgactgattt
    22381 tgaaatacaa ttgagaatcc aaccattatc ccagcaaaag caaataatag tgttggtgta
    22441 aacattgccc ctccaaaacg ctgtattttc ttcatcatat aaattactcc cctcctcata
    22501 tttttagttt atctttggcc ttagatatct attattttaa caggttaata aatatataca
    22561 atctttaggg tacattcgga gcttattcac agtcaaataa gtttttgcac atttttatgt
    22621 tcaaattctc ataaaaaaaa agaatgacta caatttgcaa tcaatccctt ctgtaatcat
    22681 tctatgcctt ttataaatac tatatttaat aaataataac tcaatcaata taaaatataa
    22741 cattgtcaat ttataactag ggtgcatttg taaaaatgag atattagtcg ctgaaatata
    22801 aattgattca tcacttaaat cagtcaatgt attattttta aactctgtaa ttgaaattat
    22861 tttagttcct attaatttta atcttctagc aatattaagt gtattctcat tctcaccact
    22921 tagggatata ataatcataa catcattttt actgacaata ttgtaaaaag aatcatcaaa
    22981 tgttcttccc tcaaaatcat atattatttc ttgacatgat aagaacattc tctttatctg
    23041 ttttgcaacc acattttgaa tatcacctga accataagcg tatattgttc ttgattcata
    23101 aagaagttta cacaatgcat cataatcttt atttttttga tcttcaacat acttaattat
    23161 tgaattacat gcaatatcaa atgactgatt ttctatgaca tgaacctttt ctgattccca
    23221 gcttaataat actttaaact cactgaaacc ttttaaatct aattttttaa caaatcttgt
    23281 aatagttgca cgagacacat tacatttcat agcaagttca tttattgaca tcttactaca
    23341 atgtttttta tttgcagtta tatatttcca tattaataaa tctgtatcat tcaatttatt
    23401 ataatttaaa aaaatcattt cttctaatct cataaactat tacccccttt aattaaaaat
    23461 cgtcataaat attataccaa tattcaacat taaattacag cgtattctta tatttactat
    23521 ttagcccata aaattgacta taaaaaatac tgctataatt gatgtttaaa aaaatgtagt
    23581 tttaatttta ttcttttatc taataattaa tattttcaag ttctagtgct tttcttatac
    23641 aattatcatc tttaaaatca gcagtccttt tacaatcttt tactttaaat tctggaatag
    23701 ttttaaattc ctcatcacat attccattct tatttaaata catacaactt gccattctaa
    23761 ctattagacc actatttttt aaattaaaca atacagggtc tatacaccct ccatctccgc
    23821 cagtagtttc accaactaaa gtcgcaaatt tattttcttt acaaaacatt gcaaatgact
    23881 ctgatgatga atatattttt ctatcaacaa gtaagtatat attaccctta aattttgaat
    23941 catctgtaga ttttatagta taggaagtat cttcaaaatc attaaaatct tttataattt
    24001 ctttaggtgc attttccttt acacttgctg gtaaattttc tacaggattt aattttatat
    24061 ttcttgcatt tgtatatttt tttactattt cattattatt tctataaatt ctataaccat
    24121 ttattttgac atcatttttt atgagtttag atacgattcc ctgccaatac ctatcacttc
    24181 cacctaaatt acctcttata tcaataatta aagctttatg tttttctaaa gtgttaatat
    24241 aatctccaat tatttttaaa tcattattta tagagccatt ctttgatgac attgatggta
    24301 aatacatata tccaatctga cccttaataa catcctttaa aattaattct ttttttacaa
    24361 aaatatcatc tggcattttt attttaagat tcatagagtc atatctatcc acaacttttt
    24421 tatcattaag aaaatcatac caatcattat tagagtatga tttcttaaaa agttcatatc
    24481 ttttcttatt atctattact tctgtgtgtt tattatttaa atcagataat atagatgaca
    24541 gttcttctat aaattcttca tcattttcag tgttttttat tcgttttgta tattcatcct
    24601 tatttgctaa ccaatcaata ttattaagcc tcttatttac acctagatat ggatatcctg
    24661 tctttacaac attatacaca taattaaagt catccacctt ttcctcttca gacaactgat
    24721 tcttttgaga ataagtagaa ttacctaata atattataaa tgctaaaata attactaaaa
    24781 ataatacttt ctttttcatg taattctcat ccactttcag attttatatt ttaatacatt
    24841 gtatcattat tttattatca cctaaacagt taaaagaaat tcttgaagat atattccact
    24901 attattctat ttaaaaattt ttatttgtat tttcaaaatt atttcatgaa agttataaaa
    24961 taacaattat attcaaatat ctattttact gctatatcct gaaagtaaat tcttatcagt
    25021 gatatactaa aaaagatatg ctaaaaaatt tatccattat aatgacttaa atttagatac
    25081 tttactgatt tttatttatt agttgagaaa gatattgata attaaaaata ttgataacta
    25141 tagaaatgat tattttttat agaaatttta aggatataaa ctaattatac ttaagtctat
    25201 atccttaatt tatcatgatt atgagaattt ttacaaatac ttatctttgt ccgttttaga
    25261 ataaaaacaa gaacatatcc tgttatttta ttcaaacatc caagtttaat tactacacaa
    25321 ttacttatta gaaattgtat ctacttcata tatatatctg ttaagtatag cttctagcat
    25381 ttcttgtctt ccagacttat tctttataac tggcatttgc agtgcataag attctaactc
    25441 tttaaatcca accttacctt ctactatatc cttacctata ccttcactaa aacttgcata
    25501 tctttcttta gtaaagttct caaatacctc atcttctaat aatttatgag ctattaataa
    25561 tccctttgca aatgtatcca ttcctgcaat ataagctagg aataagtctt ctacctcaaa
    25621 agatgctctt cttactttag agtcaaagtt aaatcctcct ggtgctattc caccttgctt
    25681 taacacttca tacatagcaa gtgttgcatc atatatattt gttggaaatt ggtctgtatc
    25741 ccaacctaat aataggtctc cttgatttgc atctatacta cctaaaacat tgtttattct
    25801 tgctatattt aattcatgtt ggaaagtatg tcctgcaagt gttgcatggt ttgcttctat
    25861 attcattttg aagtatttat ccagattata ctttcttaaa aatcctaaaa cagtagcagt
    25921 atcaaaatcg tattgatgtt tagtaggctc ttttggctta ggctctatta agaattgtcc
    25981 actgaatcct atttccttag cataatctac agccatttgt aagaatcttg caaagttatc
    26041 catttcaagt tctgtattag tgttaagtaa agtttcataa ccttctcttc caccccagaa
    26101 tacaaaattt tctcctccta agtacttagt tatttccata gcttttttaa cctgagctgc
    26161 tgcatatgca tatacatctg cattacatgt tgtagatgca ccatgaacaa atcttggatt
    26221 tccaaacata ttggcagttc cccataataa ctttatacct gtcttttcca tattaacttt
    26281 tatatactca actatttcat ctaatatctt atttgtctct tctaaatctc ttccttctgg
    26341 tgctatatct ctgtcatgaa aacagaaata ctcaattccc atcttagaca taaattcaaa
    26401 tcctgcatca actttaatct ttgctatctc aattgggtct gttatattat tccaaggtct
    26461 ctctactgtc cctactccaa atgggtcatt accctctcca cataaagtat gccaatagct
    26521 cattgcaaat cttaagtgtt ctttcatagt cttattacct accacttgtt caggattgta
    26581 gtatctaaat gctaattcat tgtcagattt tactccttca aattttatct gtcctattcc
    26641 tttaaatatt tcactcattt catgtcctcc taatatttta cacatataat atatgtagta
    26701 tgttttctta atttaaaact attttctatc tttatttttc tttttaagct aatttaatta
    26761 tttatttttg cattaactac ttcatctaat aacttaaagt catctttcaa agatttgtat
    26821 attcttttat acaatctatg atatatattg tatgtatcta cattttcact tattggttct
    26881 aatttagttg aagtttttat tatagcatca caagcttttt gtatattttc atatattcca
    26941 gctcctacta atgcaagaat tgcaactcca agtgctggtc cttcacttga atttatagta
    27001 tatacatctt gattaaacat atctgcttgc atctgtctcc atactttact ttttccacct
    27061 ccacctgagg ctcttacttc attaacgtct atattaagat tctctattat atccatacag
    27121 tctttaagac tatatgaaac accttccatt attgaccttg cgatttcttt tttagaatgg
    27181 attggagata atccaaagaa cacacctctt gcataagggt caagatgagg agttctttct
    27241 cccatcatat atggtaagta aagcaatcca ttacatcctg ttggtacttt acttacttga
    27301 ttatttataa tctcatatac atcttcacct aaagaatttg aaacttccac ttcactttga
    27361 cagaaattat ctttaaacca ttttaatgac aagccagctc cttgagtaac tcccataaca
    27421 tgccatgtat ttggtattgc atgacagaaa gtatgaactc taccttcttt atcaattttt
    27481 ggctcttttg tataagcaaa tactacacct gatgtaccta tagtagatga aactactcca
    27541 tctttaacta ttccatttcc tatagctcct gctgcttggt ctccagctcc tcctaccact
    27601 attgttcctt ctttaagccc tgtcaaactt gctacatctc tagtcacata acctgtaatt
    27661 tcttgtgatt cataaacttt acctaaaaga tttttatcta tatttaactt ttctagtact
    27721 tcatcgctcc aatctctttt tcttatatcg agcaactgca taccacttgc atctgatacc
    27781 tctgtagcat attcacctgt caatttgtat cttatataat cttttggaag aagtatttta
    27841 ttagtatttt tatatatatc tggttcattg tttctaaccc ataatatctt tgatgctgta
    27901 aatcctgtaa gtgctggatt agcagttatt tcaatcagtc tttcttcacc tactaaatca
    27961 gttatctcct cacactcttt tactgttcgt tggtcacacc atattataga gtttctcaat
    28021 gttttacctt cattgtccag aataactaga ccatgcatct gtcctgataa tccaattcct
    28081 tttatacatt cactgcttat atttgaactt tgaactactt ctcttataga ttcgactaca
    28141 gctttccacc aatcatttgc atcctgctct gcccaacctg atttctcttg tataagagga
    28201 tattcatatg tacaactttt tatagtattt cctagtttat caaataaaac tgttttcgta
    28261 cctgatgtac caatatccac acctaataca tactccaact tcatccctcc ttgaatgcca
    28321 cttcataact atcgttttcc tatcctaatt tttttatatt ttaggtatat tttacttgct
    28381 ttatttttgt tagtatatta aactaactta tgaactaata ataaaatatt taattatctt
    28441 tgtcaatgca aaataacctt ttatttttgt gtaaaaagta ttacaatatt attttaagga
    28501 ggaatatcaa attggttact gataaataca ctattcgaga aatgaatgaa agattggtac
    28561 ttgaacaaat tataaaaaat ggtcctattt ctagggcaag tatagcttct accataggat
    28621 tgaataaagc aactatatcc gctattacca aaaaacttat tgatgaatct ctagttcatg
    28681 aaatcggaat tggaaatagt actcatagtg gcggaagaaa acccatatta ttagtattta
    28741 ataaatgtgc agggatttct ttaagtatgg acattggata cgactatata ttttcttctc
    28801 tatcttactt agatggaact attataaatt ctaagaaatt aacagatata caagtaagta
    28861 aagacaatgt tatacaattg atagatgaaa ttataaatag ttataacata tccaaaatag
    28921 acactcctta taaggtaatt ggtcttactt tggctataca tgggattact tgtgaaaata
    28981 aagtattgtt tactccatat tacaatctta atgagattga cttatatagc atccttagca
    29041 aaaagtatga ctttcctatt cacatagaaa atgaagcaaa cttaacagct ttagctgaga
    29101 atactttttc aactgtacat aactcactac ttagtctcag tattcacagt ggatttggtt
    29161 caggcattat aataaataat aaattatata gtggcagaaa tggtatgagt ggagaaattg
    29221 gtcacactat catcatgcct aacggtaaac tatgtccttg tggaaatcgt ggctgtttag
    29281 aacagtattg ttcagaaaaa aaggtatttg aacagctttc ttctttagaa aatattccta
    29341 aaatagattc tgatatagta aagcaactat attatgaaga taaccagaat gccaaaaaag
    29401 ttattcatga gttttgtagt tacttaacaa tagctataaa taatgctatt acaacttatg
    29461 ctcctgaaat aatatattta aatagccaaa taattagtga tatccctgag atattacaga
    29521 ttacaaaaga tatgttagtt agctctttta acaaaggaat aaatatagaa atttcatcat
    29581 tagggtctga ggcatctcta tatggtggct ctgccgtaaa tatcaagagc tttttgaata
    29641 tacaaaattt aactttaatt aatgaaatat aagggttatg actatataca gccataaccc
    29701 tttaaattat acattctaaa attagattta ttatatagtt tatgcaagat tagctatatt
    29761 ttttaaaaat tgtatatcaa ttaaatatta acataagtat ttcgttttaa atattaatat
    29821 aatcttccta ctcatcatca gataataaac ttgcattttg ttcaaccata gaaatattat
    29881 ctttacctat tttctctaat tttgctgcca attcctttgt atctaaaaaa gctgattcaa
    29941 taaccatacc taaatttagc cctgaaataa ttttaattcg actgtcatta ttggctacta
    30001 ataaagcagc attgcatgga gttccaccta gtaaatctgc cattataatt atttctgaac
    30061 tttccttgta cacttctaaa gcttttttta atttttctat tgttccttct attccatcat
    30121 cttgtttcat gtttacagta ggataatcta tagaatcccc tattatcatt tttgcagaat
    30181 ttaagacttc ttcagccata ttgccatgac tcatcaaaat aatactattc aatttaatac
    30241 acctctttaa atctataaga tgtctacaag ataagttttc ttatcatcag gcgtcattat
    30301 agttgtaatt tcaattcctt catctaaaag tcttttaaat gcttctttct cttcttcagt
    30361 aacactgata ttaggtctta gaactgttgt atcttttcta cttgacatat ttcctacatt
    30421 tatattatgt attttaaatc ctgcctctac aaatggaata aggtccacag gagacttaac
    30481 aattaataat acattttgtc cttcatactt tcctgcagta atatttttta tagcagtctc
    30541 ttctgtaatt atagatgacg ctatacctgc aggtgtagcc attcttaaaa cttgtttttg
    30601 aacagaattg ttagctactg catcatttac taccattaat cttgtaacac ccaatttatt
    30661 actccacata gttgcaactt gaccatggat taaacggtca tctatacgaa tatttttaat
    30721 acctttcatt tccatatcta atatcatcct ttccttattt taaaatacct aatgcatata
    30781 aaattattga aacaaccatt actcctaaaa ttaagtatat aggttttata ttctttttaa
    30841 gagcccaata aacaatcaca actaaaattg caggaactaa cccaggcata atttggtcta
    30901 atatttcttg acctttcatt gtaaaatcac cttgttgaaa gttcaaagca acattagctt
    30961 ttacaactga aggtattaat gcacctacaa ccattaaacc taaaatagat gtactctcag
    31021 ttaaaatctt taaacttttt tcaattgaag atattagctt agtacctgat gtataaccag
    31081 cattaaatag tggtatactt aataatttca atgctacact cactacaatc cacagtaaga
    31141 ttccaaatgg acttccatct atcgccatat tagctgctat agctccaaaa attgtccacg
    31201 gaataacgac aaataaacta tctcctaaac ctgctactgg tcccatcaag cctgttttaa
    31261 ttgaagcaac agcctcttca gtctcttcac ttgataactc ctccattgct acattaatac
    31321 ccaaaatata aggggcaacc caaggattag tgttaaaaaa ttgtaaatga tttaatacag
    31381 cactttgtaa cttttctgga ttatctttgt atactacttt taaaaaaggt agtactgcat
    31441 aacagtatgc caaggcctgc atcttctcat aatttgaaga aacagaacta gtaaaaaacc
    31501 agcgccataa gacacttttt ttcacctttt catttgattt atttaatgat accttatcac
    31561 tcatcttcgt ccatacctcc tactacagta tattgttgtt cttgattttc caaattcttt
    31621 ttgtaaatta taagtgcaat tgctccacca attaaagcta cacctaataa tggtactttc
    31681 atatatactg ctaaaacaaa accaattact aagtaactaa aatactcctt agcaggaaga
    31741 tatctaagta ataatcctat ccctactgct ggaagtagtc ctccagctac tgttaaacca
    31801 cctgttaacc attcaggtgt atatttcaaa atggtattaa ttaaagaagg tccaaatatt
    31861 acagatagag caactggaat acctgttgta gctgctgtta atagtactcc taacatttgc
    31921 atataggtta tatttttata atttcctttt ttagctccat cttctgcttt atgaactagc
    31981 catataccaa tagtatttct aagaacatct aattgtacca tcaataaagc aactggaata
    32041 cctatagaga ttcctacaga tgcttcttgc ttagtcgtaa tagttataaa tgtggctact
    32101 atacttgctg tttgataatc aggtattgat gctccaccaa agttactaat acctaatgat
    32161 aatagctgta atgtacctcc aatatataac cctgtattta tatctcctaa gataagacca
    32221 gtaataaaac ctgctgttac tggttgatat gttccaaaca ttgttgaatt tttttcatag
    32281 tttataaaaa atccatatag tacgattaat aataattgcc ataattgtgg ctccattatg
    32341 atttcacctc tcccaaaata ttttttagtt ctttaaaatt ataactggaa tcttgcttta
    32401 ggaaaatagg aatttcttcc agtgggcatt caacttcata agttttccca ccttcataac
    32461 taactccact aaatatattt tcccatgtat gtccttttgg taaatatact tttctacttc
    32521 tatctttata attcattatt ggagctacta aaatttcatc tccaagcata tatgtattat
    32581 ccacctccca agttttatca tcttcaggaa attcataaaa taaagttctc ataactggtg
    32641 ttccatcttc atgcgcttct ttcatcagtt tttttaaata agtttttaag ctctctctaa
    32701 tttttatgaa ttttgtaaga attacttcaa cttcttcacc ataagaccat atttcattag
    32761 gagctccagt taccattgag cctccacctt tatttgataa tggtttacta tgaggcaatc
    32821 tatctccatg cattctcaaa attggtgaaa aagtagcata ttggaaccat cttaccataa
    32881 gttctctaaa ttctgggtct ttaggatttc ctccatggaa acctccaata tcagtagtcc
    32941 accatggtat acctgccagt cccatattta accctgtatt tacttgatta ttaaaagcct
    33001 caaaactaga atcaatgtca ccagaccata ctaaagctcc atacttttga gctcctgccc
    33061 aagctcctct tacaagagtt acaacagact ctatgtcatt atgtaaacca tcataaatca
    33121 tttttaaata atcaatagga taaatattac cacaacttaa aacatttcct tttttatatc
    33181 tatagttatc aaaatcatac acagaatagc caggttcagc tacatctaac caataatagt
    33241 caatcccaag ttgtttataa tttttatcta ttctatccca aacatattct cttgcatttt
    33301 catttgtcat atctacaaag actgtatttc cttgaatttg cattgtcatt ctaacaccac
    33361 gattaacatt gactaaatag ccattttcta aataatcatt gtagttttct gcatcacttt
    33421 gaactgtagg ccatacagat actattggtt ctactgaata ctcttctttc aattttttaa
    33481 ctaattcttt aggatttttc caataatcta agtcaaattt atattcacct tgcttaggcc
    33541 aatgaaaata gtcaattgca attgatgaaa gcttaattcc tcttttagaa tattccttca
    33601 caacatctaa aacttcttct gaagttctat atcttagttt actttgccat agtcctaaaa
    33661 ggttttcagg catcatagga acagttccag taacttgaga ataattttta tttaactctt
    33721 ttgggctttc tccacaagta atccaataat ctataaaatt tgtagaaaac atcttccatt
    33781 ctgtcatatt tttagcaaaa gatacttttc caattcccgg attattccat aaaagtccat
    33841 aacctagact agaaatataa aaaggaactg atatttgaga atttctttgg gctaactcca
    33901 aaacagtatt ctttaaatct aaaaatttat gttgatattg tcccattcca aaaatctttt
    33961 cagaaggctc agattcaaat ctagtagtta cttcaaattc tccactatag cttggtcgat
    34021 attctcttga ttttaacttt agagtagagt taaagtcttt ggtaatctca attgtcccta
    34081 catcttctcc accatcatca tgttttacag ctcttaatcg aatatattct ttcaataata
    34141 tttcattttt atcattataa aaagtaattc tatctctatg gtctaagaca gcttttatct
    34201 ttccattttt aatgattgca cttccatctt catttttatt aattgtaata tcatctttat
    34261 ttaacttagg tttttcgtta agagcatagt tttcatcaac aaaattttgg tctacaaacg
    34321 acctaatacg taaagagttt tttccccatg cttctattcg caatagttca ttgtcaaatc
    34381 ttttttcaat atagtcttca gatattttta tcacggctac ctcctaaatc aatggtataa
    34441 tattctatct ttgtgtagct taagttaaat aatgtcgttt agtatcgtta tttataaatt
    34501 aggttttata tataattcat ttgtacatta aactaactta ccaataatat actttatttg
    34561 actttgtttg tcaatcgctt tccggatttt agtaaaattt tctaatatgt tgcttgaaag
    34621 tcgttcttaa tatcttttat ttatactttt aatatctgtg atgataccta tatacatcta
    34681 gtttttttaa aacacataca gaaataaagt ttgcctatta tgtagataat atcggacttg
    34741 aaaatatgta tagtgacctt ataaatacag ataataatat attagatatt gttcaaaaca
    34801 atggatttta taattataaa taatttatga aattatttaa taaaatatat aattgtatac
    34861 caagtcaaaa acgacaacaa ataaataaaa ctaaaaaaga tgttgtctca aaatatagat
    34921 aaatttattt ttcattgcta aaatgattaa aatatatttg atttaatata cttgatttaa
    34981 tataaaaaaa gagtgtctca taaactaaaa agttcacttt tagacactcc tttatatata
    35041 ttatctactt cttaattcat ttattacctt tctacatttt ctttcagcta gtggatacat
    35101 ctttataagt actaattact ccacttaaaa atggttcctg tactgtccat cagtcatatt
    35161 tttctgccaa atataatggt gtttcataat gagacaataa atatttatat ctctacttat
    35221 cttctctaag ctcgtcaaat ccaactatag gtatctctaa attatattct ttaagtagct
    35281 tttctagctc ttctataaaa atacctttcc catccaccat ttgtatatca tttattttat
    35341 ccatcaattc attgcaacca cttaactcac caaaccaacg tttagaacta catgtcttat
    35401 tataaccaca acttggactg ccatctattg caatgatact ttttatatca taatcatttt
    35461 ttaaatattc atcaaactgc cttacatgag gtattaacat ttgcctacat tgttctctaa
    35521 aaaacaaatt gtcaaactgt tcttttacat gtccccacct atttattcca tacataatca
    35581 tttctggaca tggtagttga attattccat accctttatt tattaaatct attgctatat
    35641 tttgtgctcc cttaaattct gacaatccct ctactttaga attacaattt aatatacaat
    35701 gacatactac tacaatctct ctatttctct tcataataat ctccttagtt attcttaatt
    35761 ttaatgatac tacatatttt gataattata ttatttattt gttctatatt tccaatattc
    35821 tatatagaaa tatacaatta gtaatctttt ataatctata ctatgataaa tgtatatatt
    35881 tttttaggag gtattataat tggatactaa aaaagtcaca ttttcttcaa tgtgcatagt
    35941 tattaatatt gtcttaggta tggttatatc tatgataaat ataccattat tatttttaga
    36001 tacagttggt actgtacttg gggctgtcgt attaggtcct ttttggggtg ctcttattgg
    36061 tggatgtaca aacttagttt taggtgttat atcaggtcct acaaatatac cttttgccct
    36121 tgtaaatatt gttcttggtc ttattgttgg atatatttct aagaaaaaag gttttggtta
    36181 taaagaagct attattacag gagtaatttt atctattgtt tgtcctttaa ttggtactcc
    36241 tatttcagtt ttattgtttg gtggtttaag tggaagtggt gctgatttat tggttggttt
    36301 tttagttcag tctggtcaga agatatttac tgctgcgttc tttccaagga ttcttagtaa
    36361 tatagtagac aaacctttgt cttgtattat ggtggtatat tttataagta aaatgcctaa
    36421 aggttttata aaacaatata gtaaaaatac ttctagttca tattaataaa tcatttatta
    36481 tgtaag
//
LOCUS       DAEQCW010000030        35750 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.030, whole genome shotgun sequence.
ACCESSION   DAEQCW010000030 DAEQCW010000000
VERSION     DAEQCW010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 35750)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35750)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35750
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.030"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(230..742)
                     /locus_tag="KRO40_001502"
     CDS             complement(230..742)
                     /locus_tag="KRO40_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2092323.1"
                     /translation="MLEVIKNRHSIRTYIDKNIEEDKITEILKSAMQAPSSKNAQPWE
                     FIIVDDKELLKQLSKSQHRAKHIEFAPLCIVVLGNRDKFLKPGKWIQDLGACTQNLLL
                     EVTNQGLAACWAGVFPKNKVVNKVRQTLDLPVKLVPYALISIGYSEEKNEFIDRFDEN
                     KIHRNVYKNR"
     gene            1192..1668
                     /gene="purE"
                     /locus_tag="KRO40_001503"
     CDS             1192..1668
                     /gene="purE"
                     /locus_tag="KRO40_001503"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HBH2092324.1"
                     /translation="MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQL
                     SIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQM
                     PKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG"
     gene            1674..2372
                     /locus_tag="KRO40_001504"
     CDS             1674..2372
                     /locus_tag="KRO40_001504"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBH2092325.1"
                     /translation="MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGI
                     LNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVG
                     LEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
                     FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDL
                     VEGYTEVLSRMNNK"
     gene            2384..3751
                     /gene="purF"
                     /locus_tag="KRO40_001505"
     CDS             2384..3751
                     /gene="purF"
                     /locus_tag="KRO40_001505"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HBH2092326.1"
                     /translation="MCGVLGIYSNKDVTKELYYSLYSMQHRGQESCGLALLDDGEIKY
                     KKDMGLVGDVFKENELSKLKGNIGIGHVRYSTAGGSHVSNCQPLVGSCRKRQLAIAHN
                     GNLVNANYLKDMLEEDGYMFQTNSDTEVILYILARYYKGDIVESLKVTMDYIKGAYAL
                     VIMSQEELVAVRDPHGFRPLVLGKKGDEYIFASENCAIDILGGEVIRDVEPGEIIVVK
                     DGELKSYFYSENYKPVKKSCIFEHIYFARNDATIDNVNAYEFRIKCGERLAQNETVKA
                     DMVVPVPDSGWPGAIGYANASGLKISEGLVKNRYVGRTFIKPTQEEREIAVKIKLNPL
                     STIIKGKSIILVDDSIVRGTTSKQLVKSLREAGAKEIHLRITSPPVAYSCYYGIDTPN
                     RSKLIASSNNVEEMREYIGCDSLKFLDIEGMLDATEHKSTFCKACFDGEYPVKKIDKE
                     ELLSC"
     gene            3745..4821
                     /locus_tag="KRO40_001506"
     CDS             3745..4821
                     /locus_tag="KRO40_001506"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HBH2092327.1"
                     /translation="MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLY
                     SLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFF
                     LDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
                     ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVG
                     EALLTPTKIYVKLALDVLAKHDIKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKP
                     PIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFINNRENDNAAYVDKKY
                     SELLEDKAYIIGEVVDSHEGVELC"
     gene            4815..5408
                     /locus_tag="KRO40_001507"
     CDS             4815..5408
                     /locus_tag="KRO40_001507"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HBH2092328.1"
                     /translation="MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGL
                     ERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPS
                     LIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
                     TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE"
     gene            5401..6933
                     /gene="purH"
                     /locus_tag="KRO40_001508"
     CDS             5401..6933
                     /gene="purH"
                     /locus_tag="KRO40_001508"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HBH2092329.1"
                     /translation="MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGV
                     NVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNL
                     YDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT
                     MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQ
                     NGFLYSQSNAKNPILNYEQLGGKELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHAN
                     SCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFE
                     PEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKP
                     TDAQLKDMEFGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFT
                     GAVLASDAFFPFDDCVTLAHEYGISAVVQPGGSIKDKDSIEACDKYDMVMVFTGIRHF
                     KH"
     gene            6944..8194
                     /gene="purD"
                     /locus_tag="KRO40_001509"
     CDS             6944..8194
                     /gene="purD"
                     /locus_tag="KRO40_001509"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HBH2092330.1"
                     /translation="MKILVVGGGGREHAICWKLSKEKNVEKIYCAPGNAGIANVAECV
                     NIGDTNIEELLKFAKENEIGLTIVGPEVPLVMGIVDEFEKEGLRVFGPNKKCAQLEGS
                     KAFSKEFMIKHNIPTAKYKEYTNLEEAISEIDSFGYPVVIKADGLAAGKGVVIPENRE
                     DAIATLKEMMSDKKFGAAGDKIVIEEFLKGIETSILAFVDNDTIVPMASAKDHKKVNN
                     YEQGPNTGGMGTFSPSEIYTEELANKVKETVLEKTLEGFKKDGLNFKGILFVGLMITE
                     DGEKVLEYNVRFGDPETQSVLFRLETDLHEIMEAILDNKLKDIEINYSDDEAVCVMLT
                     SGGYPDSYEKGKIITGLENLDDDIVVFHSGTKMFDGNLVTNGGRVIGITAKSTTVKDA
                     AEKVYENIKKINFEGMHYRTDIGR"
     gene            8219..12025
                     /locus_tag="KRO40_001510"
     CDS             8219..12025
                     /locus_tag="KRO40_001510"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HBH2092331.1"
                     /translation="MLNTENKDSMVRRVLVEKREGFDLEAKALKKDLVESLHIDNIEN
                     LRILNRYDVEGISEEVYENAAKTIFSEPNLDVVYYEEIPKLNDERVFAIEFLPGQYDQ
                     RGDWAAQCVQIVNQGIRPAINTAKVYILSGKITDEEFSKIKDYCINPVDSREASLEKP
                     ETLKMETEIPTTVEVLDGFIDLDENGLRTFVSEKGLAMTLGDLQHVQKYFKDTEKRNP
                     TITEIKVLDTYWSDHCRHTTFMTEIENVKIEDGKFNDIVKEAYQMYLNSRDNVYVNRH
                     KDICLMDIATVAVKELKKNGKLNDLDESEEINACSINVDVEVDGKMEKYLVMFKNETH
                     NHPTEIEPFGGAATCLGGAIRDPLSGRSYVYQAMRVTGSADPRTTLEDTLPGKLMQRK
                     ITTEAAHGYSSYGNQIGLTTGQVAEVYDENFVAKRMEIGAVIAAAPKENVVRERPEAG
                     DVIVLLGGKTGRDGCGGATGSSKEHSEESILTCSAEVQKGDAPNERKIQRFFRNKEVA
                     QMIKRCNDFGAGGVCVAIGEIADSLDINLDLVPKKYDGLDGTELAISESQERMAVAIK
                     KENKDKFIQLAVEENLEATHVATVTDTGYLRMFWNGKAIVDINREFLDTNGVKQTTDV
                     HVTKVDEENTFFSSNEIVKDVKCASMKDKFTKVLSDLNVCSQKGLVEMFDNTIGGNTV
                     LMPFGGKYQATPTQGMVAKIPVLGGETNTSTIMTYGYNPKVGKWSPFHGALYAVVESV
                     CKLVAIGGNYSTTRLTFQEYFEKLGNNPEKWGKPFSALLGAFYAQSKFEIPAIGGKDS
                     MSGTFKDIEVPPTLVSFAVDTVDAKKVVSPEFKKADSKVVMLCVNKAENDVVDFEELK
                     RNLDKVRELIHGNKVLSTYALGFAGVGEAISKMAFGNKIGFKFSEEAEKAFTDDKLFE
                     ASYGNIVLELANDDLSMLEGYNYVVLGSTVKEASIFIKGEELALDELYKAHCSTLEPI
                     FPTKTEEVKSKIETISYISQGEAKKSSLSIATPRVFIPAFPGTNCEYDSARAFERAGA
                     NASIRVFKNLTYKDIEDSIDTIVNEIKSSQIIMLPGGFSAGDEPDGSGKFIATVFRNP
                     RVQEAINEFLTQKDGLMLGICNGFQVLIKLGLVPYGEIRVPSESAPTLTYNNIGRHQA
                     KIARTRISSNKSPWLAQTNVGDIHNIAISHGEGKFVASEDVMRELIANGQVATQYVDF
                     NNEATYDIEFNPNGSFYAVEGITSVDGRVFGKMGHSERIGEEVYKNIIGEKDQKIFES
                     GVKYFR"
     gene            12231..13103
                     /gene="rfbD"
                     /locus_tag="KRO40_001511"
     CDS             12231..13103
                     /gene="rfbD"
                     /locus_tag="KRO40_001511"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HBH2092332.1"
                     /translation="MKILITGSNGQLGKELVNQLEAINQSINQPKYVILATTRSDLDI
                     SNQTNVDNFILHNKPDVVVNCAAYTKVDACEDNIEIAYKINALGVRNLAIASEKVNAK
                     LIHISTDYVFNGFSKYPYREDNKTEPNSVYGKSKLMGEKFVEQFSHKYFILRTAWLYG
                     NGNNFVKTMIKLSLENTEVNVVNDQFGTPTSTVDLAKIIIKIMETEHYGVYHATCEGE
                     CSWYDFAKKIFKLKNIDIKVNPIKSNEFKCKAPRPLYSVLDNFMLKLIGLNSFRKWEE
                     SIEEYLERYDINEK"
     gene            13212..14081
                     /gene="rfbA"
                     /locus_tag="KRO40_001512"
     CDS             13212..14081
                     /gene="rfbA"
                     /locus_tag="KRO40_001512"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HBH2092333.1"
                     /translation="MKGIILAGGSGTRLYPITKCISKQTLPIYDKPMIYYPMSVLMLA
                     GIQDILIISTPRDIKAFEELFGDGSSLGLNITYAIQEKANGIAEAFIIGEEFIGNDRV
                     SLVLGDNIFYGYGFSERLENAVKRKGATIFGYHVSNPNSFGVVEFDKDFNVLSIEEKP
                     TVPKSNYAIPGLYFYDNDVVEIAKLVEPSDRGELEITSINSEYLKRGKLKVELLGRGM
                     AWLDTGTHKGLLDASNYVEVVQTRQGLYIACLEEIAYTKGYISREQLMKLAKPLIKTE
                     YGQYLLKLASEDM"
     gene            14130..14687
                     /gene="rfbC"
                     /locus_tag="KRO40_001513"
     CDS             14130..14687
                     /gene="rfbC"
                     /locus_tag="KRO40_001513"
                     /EC_number="5.1.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="HBH2092334.1"
                     /translation="MGKINVIKTKIEGLYIVEPNVFYDERGYFMESYNKKDFIEQGLD
                     MCFIQDNESSSRKGVLRGMHFQVKYPQGKLVRVTEGEVFDVAVDLRKDSQTFGKWEGV
                     ILSDKNKKQFYIPEGFAHGFLVLSEKAVFSYKCTNYYYPEFENGFIWNDKQISIEWPL
                     KGIEEIFLSEKDKKQKSFKDICTRR"
     gene            14725..15708
                     /gene="rfbB"
                     /locus_tag="KRO40_001514"
     CDS             14725..15708
                     /gene="rfbB"
                     /locus_tag="KRO40_001514"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HBH2092335.1"
                     /translation="MKKILITGGAGFIGSNFIHYMLNKYVDYFIVNLDLLTYAGNLET
                     LIEIQDNSNYKFVKGDISNREQVYKLFEEERFDIVVNFAAESHVDRSVENPDLFIKTN
                     IIGTQVLLDASIKYGVKRYHQISTDEVYGDLPIDRKDLFFTEQSSINPSSPYSASKAS
                     ADLLVSSYYRTYGLLTTISRCSNNYGPYHFPEKLIPLMILNALENKQLPVYGNGENVR
                     DWLHVYDHCTAIDLIIHKGNIGEIYNIGGHNERSNLEVVKMILNLLGKSEELISYVND
                     RPGHDLRYAIDATKIENELGWKAKYDFDLGIKETVKWYIENESWWKAVLSV"
     gene            15738..16406
                     /locus_tag="KRO40_001515"
     CDS             15738..16406
                     /locus_tag="KRO40_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBH2092336.1"
                     /translation="MNEISSLINILALTQLSGSNTTNQCNCTYNNSSGFDMIMMTLLK
                     ALSQNNQHTSNSYNLLSNSENLFNELDNVVNNTTSRFIDVDTKDKNVKLRIENAVDQA
                     SKKYNVDSNLIKAIIKVESDFNPNTVSSAGAKGLMQLMPENCRDLGVTDPFNIEQNID
                     AGTRHIKEYIDMFGGSIEMGLMAYNGGPGRMKSRGVESISDLYKMPKETQNYIPKVMK
                     YYRG"
     gene            16415..16843
                     /locus_tag="KRO40_001516"
     CDS             16415..16843
                     /locus_tag="KRO40_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YaaR family protein"
                     /protein_id="HBH2092337.1"
                     /translation="MGINIDKLNISPSINMEVKKLKESNKFSDKLNSLKQSSSLEDIK
                     RNLESVKKAGERLVLTQNYGDISIYKNAVKEYLKSVVDNMYSLDKNSSFWEHQYYKNV
                     KIVDSKLEDMTSKLISEEKENIDIVSTVDMIQGLLIDMYR"
     gene            16867..17181
                     /locus_tag="KRO40_001517"
     CDS             16867..17181
                     /locus_tag="KRO40_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH2092338.1"
                     /translation="MNSKKEDIYELNFGQLIEEKSGVIEENQNVFNAKVNVAVSIGNT
                     TETIKNILDLKEGSIIKLSKNVDEKLDIYANDRLFAYGESIITNERLSVRLSKIEDPD
                     VN"
     gene            17333..17608
                     /gene="flgM"
                     /locus_tag="KRO40_001518"
     CDS             17333..17608
                     /gene="flgM"
                     /locus_tag="KRO40_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis anti-sigma factor FlgM"
                     /protein_id="HBH2092339.1"
                     /translation="MDIKNVSSNIVVNNYLKNTSGIKKVEEVKKINKTDKIELSKFAK
                     EMASVSNMSDENIRNKKVDEIKNALENGTYKIKPKEIAKKMIEDMRG"
     gene            17613..18029
                     /locus_tag="KRO40_001519"
     CDS             17613..18029
                     /locus_tag="KRO40_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FlgN"
                     /protein_id="HBH2092340.1"
                     /translation="MITDLKVIIYEEKNIISKMMELLKEQFDYIVEKDLENLNMLNPK
                     LEDISRELASIEIKRRQLFGDDISMSEVVENSNDGYLKEIYTDLKHILALAKNQQESN
                     DSLIKKELIFTKKMINFIKPADKQTTTYNSYGNIRK"
     gene            18047..19357
                     /gene="flgK"
                     /locus_tag="KRO40_001520"
     CDS             18047..19357
                     /gene="flgK"
                     /locus_tag="KRO40_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgK"
                     /protein_id="HBH2092341.1"
                     /translation="MAGLFSILNTANSGMNAHQKAIQTISHNISNLDTDGYSRQRTEF
                     ATNSPMYMPSLSNSIARGQLGTGVHVTDVTRARNSFYDYQFRAEAHKYGKTVSKYDYY
                     NTIETILNEPSDYGISAGIDDFFKGWESLSKDINSDSKKSLVVENASNLATLISESYK
                     KLDKLKEDIDSNIDTEIKQINDMLKSLEDLNKSIDIISGSGSTPNDLLDERDRILDNL
                     SFKLDFENSDVKNMLADGKLELNELKNPDGTWKTGISGTLQGLFEMHGKIDTYKSDLK
                     DVSDGLAKQINDVYNTSAGITVTDFFITSNVDGEDIIKINPAIKSNPNELKLTADEAS
                     KIAKLKDEKIDIGVAGGKVSTISDHYKAFAESIGLDSQKVNQDEANQRKIINNIDNSR
                     MSVSGVSLDEEMTELIKIQRSYQASAKVMSTAVQLLDVVINGII"
     gene            19376..20308
                     /gene="flgL"
                     /locus_tag="KRO40_001521"
     CDS             19376..20308
                     /gene="flgL"
                     /locus_tag="KRO40_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgL"
                     /protein_id="HBH2092342.1"
                     /translation="MRVSTGMMSSSYLNSLQDNLQRLDKVNRQVNTTKEINKLSDNPY
                     KAIKILNSKSEIKTMETYVENCKDTGNWLETTDTALDQLGKLLSDIKKTLVASGDGAY
                     SDDELKTLSNETNEKMKEIANALNATHEGKYIFSGSNTGVPPVECIDNADGSVSLKFN
                     SSLNLNKLNDSLSMDIAQGISVDYNVKLSSLGFDPTKTDPFEELNNISKKLANPDADA
                     IKELTTTCLGDMEQLIENTVNVRSIYGTKANTVEAMKEKNDDSLIQLKDILSQNEEID
                     YGEKLVQLKAAELTYQASLQTGGKLFNVSILDYI"
     gene            20324..20716
                     /locus_tag="KRO40_001522"
     CDS             20324..20716
                     /locus_tag="KRO40_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliW"
                     /protein_id="HBH2092343.1"
                     /translation="MMKVTLKKGILGFENLKEYELLDIEDNDSLKEFNSTEEEGIGFV
                     VVSPFEIINEYEIVLNQETIEKLEVKSPKDVVLFNIITLGQTFEESTVNMKAPIVINI
                     KTNFGMQIILQDDKYSIRHPLLRGDNGC"
     gene            20710..20922
                     /gene="csrA"
                     /locus_tag="KRO40_001523"
     CDS             20710..20922
                     /gene="csrA"
                     /locus_tag="KRO40_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon storage regulator CsrA"
                     /protein_id="HBH2092344.1"
                     /translation="MLVISRKKDEAVLIGESIEVKIVGVDGNNVKLAISAPNNISILR
                     KEIYEKVKSENIKATNKNIKILKSLK"
     gene            20944..21339
                     /gene="fliS"
                     /locus_tag="KRO40_001524"
     CDS             20944..21339
                     /gene="fliS"
                     /locus_tag="KRO40_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBH2092345.1"
                     /translation="MYGENPYNSYKQNAVFMASKEQLLLMLVDGAVKYTKIARAAILD
                     KNTQKAHRELVRVQDIFTELMVTLDQNAGQWAKDMYKVYDFVRYELSRANIRKDIQVI
                     DSVLPVIEQIKDTWHEADKKSKEERSRDK"
     gene            21339..21695
                     /gene="fliS"
                     /locus_tag="KRO40_001525"
     CDS             21339..21695
                     /gene="fliS"
                     /locus_tag="KRO40_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBH2092346.1"
                     /translation="MELNLAELDKLSKEELLLMLVDGTVKYTNISKEALLNNDYLKAH
                     NELVRVQNIFTELMTTLDQNAGQWAKDMYKVYEFIKSELAIADENKDIKIIDDILPIV
                     KQIRDTWHEVYNQLKI"
     gene            21716..23239
                     /gene="fliD"
                     /locus_tag="KRO40_001526"
     CDS             21716..23239
                     /gene="fliD"
                     /locus_tag="KRO40_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar filament capping protein FliD"
                     /protein_id="HBH2092347.1"
                     /translation="MSSISPIRVTGLSGNFDMEGIIEASMIRDKEKVDKAKQEQQIVK
                     WKQEIYRNVIQESKDLYDKYLSVNSPNSIVSEKAYSSTRITSSDESIIVAKGSAGAEK
                     INYQFAVSQMAEPAKFTIKLNSNEPIVRQFPPNASGASSLTIGDVNIPISEQDTTSTI
                     VSKINSLCADNDIKATYSEMTGELIISRKQTGSSSDINLRVIGNDNLAQQIANDNGIT
                     FINDAGGNKVASVYGKNLEADVTDEHGRVTHISKEQNSFNIDNIDYNVNSKGTAKLTS
                     ITDTEEAVKNMQAFVDDYNKLMDKVYGLVTTKKPKDYPPLTDAQKEDMTTEEIEKWEK
                     KAKEGILRNDDELRGFVEDIQSAFFGDGKNIIALRKLGINESENYNKKGQISFNADTF
                     SKALIDDSDKVYKTLAGYSSNYDDKGMFEKLKDIVYEYSGSSTSKLPKKAGIEKTASA
                     SENVYSKQIAEQERNISRLVEKMNDKEKRLYAKYSALESLLNQYSSQMNYFSQAQGN"
     gene            23242..23577
                     /gene="fliT"
                     /locus_tag="KRO40_001527"
     CDS             23242..23577
                     /gene="fliT"
                     /locus_tag="KRO40_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliT"
                     /protein_id="HBH2092348.1"
                     /translation="MDKLKEKLNLYKDISLQIINLIEKEEYIKISIKLGERQEIINSV
                     SEIDRNDFIQLYNRMELIEIDSRIRDILQGQLLEVKKELHEYKLTKQVNTMYYNLNRE
                     KVNIFNKKV"
     gene            23679..24551
                     /locus_tag="KRO40_001528"
     CDS             23679..24551
                     /locus_tag="KRO40_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellin"
                     /protein_id="HBH2092349.1"
                     /translation="MRVNTNVSALIANNQMGRNVNAQSKSMEKLSSGVRIKRAADDAA
                     GLAISEKMRAQIKGLDQAGRNVQDGISVVQTAEGALEETGNILQRMRTLSVQSSNETN
                     TAEERQKIADELLQLKDEVERISSSIEFNGKKLLDGSSTEIRLQVGANFGTNVAGTSN
                     NNNEIKVALVNTSSIMSKAGITSSTIASLNADGTSGTNAAKQMVSSLDVALKELNTSR
                     AKLGAQQNRLESTQNNLNNTIENVTAAESRIRDTDVASEMVNLSKMNILVQASQSMLA
                     QANQQPQGVLQLLG"
     gene            24644..26785
                     /locus_tag="KRO40_001529"
     CDS             24644..26785
                     /locus_tag="KRO40_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH2092350.1"
                     /translation="MLLSIVMIVKNEEKILEKTLKSLTTLRNSIESELIIVDTGSTDD
                     TIKISKKYTEKVYFHNWNNDFSSMRNISISYAKGEWLLILDADEILIDSSTIVKFFKD
                     GLDKKFNSASIQLKNLYSYDKKLYGYCSVLRLFKNVDFRYHGKVHEQPIYKNPIFNNV
                     ADFEHYGYLFEDEEIRLNKVKRNEKLLFQELKENDNSPYTNYQLGKNFIILGKYQEAL
                     YYLEKSYELYSKLELAPGYLITSLVKTYLYLGKHKKCERLCLKYIKKDMNNIDIYYYI
                     AQAQVDLGKYENSIDSYKRYIYLLDNYEISTQANSLFSDTDTVGLRDEAIITLIKIYY
                     KLEKYEFVISEYNNIEDVEKKKNVYFSLFMSLYKLNRFEDIKNYYKEVSNSKIEKNSF
                     YRNIEEVINNIKEDEKEYVYKILCDIEGNYGILNQIRINKCVSIDKCKEILNEEKEII
                     YAYIIKIAFEEKIDLLDIFYEMEYVWIEKYLKYLLALERSFNLVLYKYIISRPNTSDM
                     EKIRVYKAISKVVLESISLSDEKYKEIFYFYIMYSYKYIRYIYSNLSDFELKKFVCND
                     LDKFTIEFKHLLDIKNKVNNANEKLEYIHSMRKLLNEYPFYNKIIKILIGELEENIKE
                     SEEFKDLKYSFIISIENMIETGKINDAKLLVDDYSKTFVDDVRILNIKGILYMFENKL
                     DKADFMLKKALSLDVENEDTIYNIEYLKSLR"
     gene            26809..28686
                     /locus_tag="KRO40_001530"
     CDS             26809..28686
                     /locus_tag="KRO40_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH2092351.1"
                     /translation="MNIPIVVNEKSKDIIKDWQYTCTNEDIKFTSIIILTYNQIEYTK
                     LCIESIRKFTPKNKYEIIIIDNNSSDGTVEWLKGQSDIKSVYNNKNLGFPKGCNQGIE
                     LATGENILLLNNDVIVTPNWLYNLNKALWSQDNIGAVGPITNACSYYQQIDVDYKSIE
                     DMFIFAHKINKSNINLWKYRLKLVGFCMLIKKTVLDNVGVLDELFTPGNFEDDDLSFR
                     MIESGYKLLLCQDTFIHHFGSVSFKENRNKYTDIMYINRRKFETKWGFNPEYSGMIRT
                     DLISKIDDSLEANINVLEIGCGIGATLLEIKNIYKNASIYGIEISESAGKLAKYSADV
                     LIANIEKVKLDYKKDFFDYIILGDVLEHLIDPWKIVNELKQYLKKDGYLVSSIPNIMH
                     VSVLRNLVLGNFTYEDSGILDKTHLRFFTLNEITKMFNDSNYIINSITATSMPLSEID
                     NSFIDTICKESCKEMRQQYESYQYIVKASKILDTKRYSSISMINLKYALMRIDNELDV
                     DSNLSYIFDNYNITEPCFVDDIEYLIDTFVINKATLLNRLGVEAFNRGLGDFSINMFM
                     TVLEMDRDDIDSIYNITSVLCELEEFDTAYNLIKNSSEKVQSESDIQEILCFIEGKKY
                     E"
     gene            28679..30793
                     /locus_tag="KRO40_001531"
     CDS             28679..30793
                     /locus_tag="KRO40_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH2092352.1"
                     /translation="MNNDKICFITCVNDERLYEECLVYINSLDIPKNFSIETVALRGA
                     DSIASAYNKAMRETDSKYKVYLHQDTFIINKNFIHDILEIFKKNTDVGMIGVAGVKDM
                     PVNGIWWDSDKKAGKVYDSHTGKMDIYEFSNFEECFNEVMAIDGLIMITQYDVFWRED
                     KFDGWHFYDLSQSMEFRQNKYKVIVPKQNKPWCMHDSGVVNINNGYDEYRIKFVKEYI
                     NLDLYRENFYEFDKKKASTILKSNKHVMDCMKEELTEQLRLKNYKDVLGIVSKIAHFS
                     VFNHTGLYSCEECERALLECANNLPEIENTKLFTKKDLKRRKVLHVLSEGYSTGGHTR
                     LVKNWIEIDKDSVHSVVTTWQSDTLPDWLLKAINDSGGEVISLDLISDDYLKRAVALR
                     KIAYDWADIVILYVHMWDTIPVVAFGVDGKIPILHVNHYDSTFWLGTSIADIVIDFSE
                     TSQLITLDKRGIDKSEILPMPLKEKEVFSKSEVRKRYNLEDDVTIILTIASERKYNSV
                     NDINYFKIAKTLIENTDNTIIIVVGVDTENLYWKTLSNVTDNRVICFGTTANIDDFYK
                     ISDIYLESFMVGSHTSKLDAILYDLIPVKFKNEVSPIFTNMWNFIDKFDYKNIKEVID
                     MIRRYNTSEFDRDKIKAKQSEIKHFVIDKHCIEIKNYIDKIYNEVNHHKVKYDLYKND
                     EIEDYQLFVALYGYMVKNKNMS"
     gene            30802..31797
                     /locus_tag="KRO40_001532"
     CDS             30802..31797
                     /locus_tag="KRO40_001532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation glycyltransferase
                     FemA/FemB family protein"
                     /protein_id="HBH2092353.1"
                     /translation="MNNIHINKFEKSCEKNWDYFVENKSINGTFLQTRNFLNYHEEGK
                     FTDHSLIICKGEEILAVVPACETYEDGERIFFSHLGSTFGGIIIRSGFNDIRHVNAIT
                     NKLEIYLQEQNFDKVYLKNTSRIFCKEDTSLLEYFLFKNNYMFYDELSMFLELSKYKE
                     DILANFKYSKRRDFKYSLKNNLTFKRLYSDEDIVCFFNLLSNCLDSKGAKVIHSVEEL
                     LEFKNNRLKDIVEFYAVYIDDIMICGSMVFNFQERVYHTQYLASNSTYNKYYPMIFLY
                     YNLIKDALERNFKYLSFGISTLNRGKYLDEGLATFKEGFGSSAICNRTYYKNINK"
     gene            31889..33121
                     /locus_tag="KRO40_001533"
     CDS             31889..33121
                     /locus_tag="KRO40_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HBH2092354.1"
                     /translation="MKRLMILGSIKYFENIVMSAKREGIYTIVCDNRIDTPAKKICDE
                     AIDVDVFDFDKIKNIAIDKKIDGILTGFTDSLMKPYVYIANELNLPCVISCNQLESVT
                     NKAVMKNYFKNNGIPTTDYCIIESLKDLEKIQGLNFPLVIKPVDGYGSRGVYFVSNIE
                     ELIEKFEYSKEASQDGQVIIEEFYESEEIQGLAWVHNGESHVFYIGDRELVNIHTGRA
                     GKPDRLIYPSKYCFQYEEEIKSIYQNITQAFGIKNGPLYVQMLVGAYGIKVSEVMPRL
                     PGGCDYMAISQITDLDIGSLFANFSVNNEVNFDEIKKYNMHLSKCVYALPIYIRPGTI
                     KKINNIDKIENLDYVTQFLLLVKEGDTIGLYEDERQDCGRVYGVANNVFDANIKKKCI
                     HEMIEILDENNENMIENF"
     gene            33141..34085
                     /locus_tag="KRO40_001534"
     CDS             33141..34085
                     /locus_tag="KRO40_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase"
                     /protein_id="HBH2092355.1"
                     /translation="MKLITHEQIMSLNISQKQGYEWIKESFLTKKDCQLPPKISMVEE
                     GHVFYNVMPSLNHNHKIGGIKMVTRLPGRNPSLNSEIFLYNMEDAKLKAILDGNYITA
                     FRTAAVAALAIDTFAKKDFNTIAIMGLGVTASAIMNMLSYTLKDKNINIKLLKYKDQA
                     ESFVKKYEKNEQFSFEICDTHEELIVDSDVVISTVTYTDEYLSEFKWFKKGALLLPVH
                     VMGFGNVDYLFDKVYLDDYNHLKHLENIDRYKYSCEFYDVLSKQAKGRENDDERIISY
                     NIGLSIHDILFANKIYELCETLSCEEIELKEPKEKYWI"
     gene            34179..34586
                     /locus_tag="KRO40_001535"
     CDS             34179..34586
                     /locus_tag="KRO40_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WxcM-like domain-containing protein"
                     /protein_id="HBH2092356.1"
                     /translation="MDKYNLIRFVSIGNEYIGNLVALESNKAIPFDIKRVYYIYDVPN
                     NVKRGFHAHKNLEQVLVCLNGSVKIKCYDGVKETIFNLHKNDVGLYIGTGVWHEMFDF
                     DEKTVLISIASEHYNEEDYIRDYKEFLKYLNNV"
     gene            34673..>35750
                     /locus_tag="KRO40_001536"
     CDS             34673..>35750
                     /locus_tag="KRO40_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="HBH2092357.1"
                     /translation="MLVKFNNLLKQFQTHKEEYEQKIKDVMESGYYILGNEVKHFEEE
                     FANYVGSKYCVGLASGLDALIIAFRALGISKGDEVIVQSNTYIASVMGISINGATPVF
                     VEPNEYYNIDSSKIEEKINSKTKAILVVHLYGQASNMKDIQELCDKYNLYLIEDCAQS
                     HGAKYDGKMTGTFGDIGCFSFYPSKNLGAFGDAGAIVTSNEEIADKVKILRNYGSEKR
                     YYNKFVGYNSRLDEIQAGLLRVKLKYLNEIEIEKSKIVDRYLNEINNPKVILPKIENN
                     CTHVWHLFVLQVEKRDTFMEYLKKSGIESIIHYPIPPHLSEAYAYLGYKKGSFNIAEN
                     YSDKVVSIPLFIGMEDEEVSYIIKI"
BASE COUNT        14639 a         3592 c         6534 g        10985 t
ORIGIN      
        1 aaaatacttt aatgaaaaat agctaacttt aattgtagga tattcttaat atatttgaaa
       61 taaataaaaa tattgaagga tataatattc aattggtata taaataataa atgatagtta
      121 aattttacct tagaggctaa ttaggtgttt aatcaaagtt aatgccttta gaatacaaat
      181 gtattctaaa ggcattttta ctatgtattt tcatttatat tactaaacat tatctatttt
      241 tatatacatt tctatgtatt ttattttcat caaatcggtc tataaactca tttttttctt
      301 cactatatcc aatagatata agtgcataag gaactaattt tactggtaag tctaaagttt
      361 gtctaacttt atttaccact ttatttttag gaaatactcc tgcccaacaa gcagctagac
      421 cttgattagt aacttctaat aataaatttt gtgtgcaagc acctaaatct tgtatccatt
      481 taccaggttt taagaattta tctctatttc caagcactac tatacataat ggtgcaaatt
      541 ctatatgctt tgctctatgc tgtgactttg agagctgttt cagcagttcc ttatcatcta
      601 ctataataaa ttcccaaggt tgagcatttt ttgatgaagg tgcttgcata gctgatttta
      661 gtatttcagt tattttatct tcttctatat ttttatctat atatgttctt attgaatgtc
      721 tattttttat aacttctaac atacagattc tcctttaaat aaaattattt ctatttatat
      781 aatatcatta ctttaaattt tagctattac ttatataaag aataaacttt gtgttggttt
      841 tatctaagta aaagtaacat tcagaactaa aaaacaagac tataaatcca aagtattaat
      901 taaaaaagaa gtaataaaaa ataatataca agatttaaaa aagagtattg ggcttaaaat
      961 ttaattagaa aaccaatttt gagataatct gttttttatt ttaacaaaaa aacataaata
     1021 aagttcgata catagcgaat gaaaaaatta caagaaatat tttttttaaa aaatttcaaa
     1081 aaagagttga taatatatgt atattaatat aaaatttaag gtgtataatt cgtataataa
     1141 tacgaatgat ttgtagtgta aaataactta taaacggaga ggggaagtct aatgaaagta
     1201 gcagtagtta tgggttcaaa atcagattat ccaaaattag aagaagggat aaaactgctt
     1261 gaaaaatatg gaatagaagt tgtagcaaga gcattatcag ctcatagaac accagaacaa
     1321 ctttcaatat tcctaaaaga aatagaagat gatactgatg taataatagc agcagcagga
     1381 aaagcagcac acttaccagg tgtaatagct tcacaaacat taattcctgt aataggatta
     1441 cctattaaat catcaactat ggatggacta gactcacttt tatcaatagt tcaaatgcca
     1501 aaaggaatcc cagttgcaac agttacaata gacttaggtt taaacgcagc tttattggca
     1561 ttacaaataa tgactttaaa atacccaaaa ttaaaagagg atttgaaatc atatagagaa
     1621 gagatggcac aaaaggtgtt agaagacgac aagaatttaa gggggtagca gaaatgttat
     1681 tatatgaagg aaaagcaaaa caagtatatt ctacagataa tgaaaatgaa tatgttgttt
     1741 attataaaga tgatgcaaca gcatttaatg gagaaaaaaa agcagaaata tcttcaaaag
     1801 gtatactaaa taataagata tcaacaataa tctttgaaat gttaaaagaa aataatataa
     1861 atactcactt tataaaaagt ttatcagata gagaaatgtt agttaaaaaa gtagagattt
     1921 taccattaga agtaatagta agaaatattg ctgctggttc tatctgtaaa agagttggtc
     1981 ttgaagaagg tgtagttttc gatgagccaa tttttgaaat aagctacaaa aatgatgctt
     2041 atggtgaccc aatgctaaat gatgattatg cagtggcaat gaagttagca actagagaag
     2101 agttaaaatt cttaagagaa gaaactttaa aaataaacga gttactaaaa gcatttttct
     2161 taaaattaaa cctaaagtta gttgacttta aaatagaatt tggtaaagat tctgaaggaa
     2221 atataatatt ggcagatgaa gtatcaccag acacttgtag actttgggat gtaaatacaa
     2281 atgaaaagtt agataaggac agatttagaa aagaccttgg agaccttgta gaaggttata
     2341 cggaagtact ttcaagaatg aataataaat aggaggcaaa tgtatgtgtg gagttttagg
     2401 gatttactct aataaagatg taactaaaga actatattat tctttatatt ctatgcaaca
     2461 cagggggcaa gaaagctgtg gtttagctct tttagatgat ggagaaatta agtacaaaaa
     2521 agatatggga ttagttggag atgtttttaa ggaaaatgaa ttatctaagt taaaaggaaa
     2581 tatagggatt ggacatgtta gatattcaac agctggagga agtcatgttt ctaactgtca
     2641 acctttagtt ggaagttgta gaaaaagaca attagccata gctcataatg gaaatctagt
     2701 taatgcaaat tatttaaaag atatgctaga agaagatgga tatatgttcc aaactaattc
     2761 agatacagaa gtgattttat atatacttgc tagatattac aaaggggata tagtagaaag
     2821 tttaaaagtg acaatggatt atataaaagg tgcatatgct cttgtaataa tgagtcaaga
     2881 agaattggtt gcagttagag acccacatgg attcagacct cttgtacttg gtaaaaaggg
     2941 tgatgaatat atatttgcat cagaaaattg tgcaatagat atacttggcg gagaagttat
     3001 aagagatgta gagccaggag agataatagt agtcaaagat ggagaactaa aatcatattt
     3061 ttattcagaa aattataaac cagttaagaa aagttgtata tttgaacaca tatactttgc
     3121 aagaaatgat gcaactatag acaatgtaaa tgcatatgaa tttagaatta aatgtggtga
     3181 gagattagct cagaatgaaa ctgtaaaggc agatatggta gttccagttc cagattcagg
     3241 ttggccagga gctattggtt atgcaaatgc tagtggatta aaaataagtg aaggcttagt
     3301 taaaaataga tatgtaggaa gaacatttat aaaacctaca caagaagaaa gagaaatagc
     3361 agtaaaaata aaattaaatc ctctttcaac aataataaaa ggaaaatcta taattttagt
     3421 agacgactca attgtaagag gaactacatc taaacaatta gtaaaatctt taagagaagc
     3481 aggagcaaaa gaaattcatc ttagaataac ttctcctcca gtagcttact cttgttacta
     3541 tggaatagat actccaaatc gctctaaatt aattgcatca agtaacaacg tagaagaaat
     3601 gagagaatat attggatgtg atagtttaaa attcctagat atagaaggaa tgttagatgc
     3661 aacagaacat aagtctactt tctgtaaagc ttgttttgat ggagaatacc cagttaagaa
     3721 aattgataag gaggaactac tttcatgtta acatataaag aatcaggtgt agatatagat
     3781 gaaggaaata gagcagtaga ccttataaaa ggtaaaataa aaggaactta tgatggaaat
     3841 gtagttggag atttaggtaa cttcagtgga ttatacagtt taaaagattt tgtaggtatg
     3901 aaagaaccag ttttgcttgc atctacagat ggtgttggga ctaagttaaa aatagctcag
     3961 atgatggaca agcatgatac tgttggaata gatttagttg caatgtgcgt gaatgattta
     4021 atttgtcaag gagcaaaacc attattcttc cttgactata tagctcttgg gaaattagtg
     4081 cctgagcata tcgaaaaaat agttggtgga attgcagatg gttgtaaaat gtctggttgt
     4141 gcactaattg gtggagaaac tgctgaaatg cctggaatgt atggagaaga tgactatgat
     4201 ttagcaggat tttctgtagg aatagcagac aaagaaaaga ttgtttctgg aaacaatgtt
     4261 aaatcaggag atgtattggt tggtatatct tcaagtggag tacacagcaa tggattttct
     4321 tttataagaa agatattttt agaaacttac aattataaaa tggaacaata tgttgaagaa
     4381 ctaggaatga cagttggaga agcactttta acaccaacta aaatatatgt taaattagct
     4441 ttagatgtat tagctaaaca tgacataaaa gctatagctc acataactgg tggagggctt
     4501 atagaaaata taacaagagt tatacctaaa gggttaggac tagatatcaa taaaaaatct
     4561 tgggagaagc ctcctatatt taaaatgata gaaggtttta atgctgttga tgagagagaa
     4621 cttcataaga gttttaacat gggtattggg ctagttttaa tagtagataa agaaaatgct
     4681 gatgatgttg taaactttat aaataataga gaaaatgaca atgctgctta tgtagataaa
     4741 aaatatagtg aattattaga agataaagct tatataattg gtgaagtagt agatagtcat
     4801 gaaggtgtag aattatgcta aatataggag ttttaatatc tggtggagga acaaatttac
     4861 aagcagttat agatggtact gagtctggag aaataaaagg tcaggttaaa gtagttatct
     4921 caagtaagca aggtgcttat gggctagaga gagctaaaaa tcataacata aaagcaattt
     4981 gtgaaactga tgaagacaag ataatagaaa ttcttaagga aaataaaata gatttagtag
     5041 ttttggctgg ttatttaaaa ataatcagcc caaagctggt taacgagttt agaaacaaaa
     5101 tgataaacat acatccatca ttaattcctt cattttgtgg agctggattc tatggagaaa
     5161 aagttcatca aggtgttata gattatggag ctaaagtaac tggtgctaca gttcattttg
     5221 tagatgaagg tgctgatact ggaccaatca taatgcaaga tgtagttaag gtaaatcaag
     5281 atgatgatgc aaagacactt gcaaaaagag tgttagaagt tgaacatagg attttaaaag
     5341 aaagtataag tcttttttgt gaaaataaat taaaacttca aggtaggaga gtgtttataa
     5401 atgagtaaga gagctttaat aagtgtaact gacaagactg gtgtagtgga atttgctaaa
     5461 gagttaaata aattagatta tgaaattata tctacaggaa atacatttaa aacattaaaa
     5521 gaaaatggtg ttaatgtaat gcaagttgaa gatgttacaa attttccaga aatattagat
     5581 ggaagagtaa aaacattaaa tccatatata catggtggta tactttataa aagagataaa
     5641 gaatctcatg tagaaactgt aaatgaacac aaaatacatt caatagattt agtagctgta
     5701 aatctatatg attttgaagg aactttaaaa gctggaaaaa gtcatgatga aataattgaa
     5761 aatatagata ttggtggacc atctatgata cgttctgctg ccaaaaacta taaggatgta
     5821 atagtagtag tagatataaa agattatgat tctataatag aaaaattaaa aacagataca
     5881 atgacattag aagacagaaa aaaattatca tataaagctt tctcaactac aggaagatat
     5941 gatgcgttaa tatctagtta ttttgctgga gaagttggag atacgtatcc tgacatatta
     6001 aatttaactt tccaaaaaga acaaacttta agatatggag aaaatccaca tcaaaatggt
     6061 ttcttatatt cacagtcaaa tgcaaaaaat ccaatcttaa attatgagca attaggcggt
     6121 aaagaacttt cttttaacaa cttaaatgat ttacatggat gtttagaagt aatgagagaa
     6181 tttaaagata gtgaagaagt agtttcagta gctataaaac atgctaattc atgtggggta
     6241 ggtttaggaa aagatgcttt tgaagcatat acaaaatgtt atgaagcgga taaggtttca
     6301 atatttggag gaatagtagg aataacttct actatagata aagctacagc agagaaatta
     6361 aatgaaatat tcttagaaat agtagtagca tatgattttg aaccagaagc tttagagata
     6421 cttaaacaaa agaaaaatct aagaatatta aaattagcta aaatagaaaa tagtttacaa
     6481 ccatatgaaa tgaaatattt agatggaaaa ttattgatac aagatagaaa caatatatta
     6541 gcagaaaaaa gtgaaaatgt aacaaaggaa aaaccaacag atgcacaact taaggacatg
     6601 gaatttggta tgagagtagt aaaaaatatg aaatcaaatg caattgcaat agtaaaaaat
     6661 ggacaaactc tagctttagg ttgtggacaa acatcaagaa tttgggcatt aaaaaatgct
     6721 cttgaaaata acaaagataa agattttaca ggagctgttt tagcgtcaga cgcatttttc
     6781 ccatttgatg attgtgtaac attagctcat gaatatggaa tatcagcagt agttcaacca
     6841 ggtggctcta taaaagataa agattcaata gaagcttgtg acaagtatga tatggttatg
     6901 gtatttacag gaataagaca cttcaaacac taaggaggat attatgaaga tattggttgt
     6961 aggcggtggc ggaagagagc atgctatatg ctggaaacta agcaaagaaa aaaatgtaga
     7021 aaaaatttat tgtgcaccag gtaatgcagg aattgcaaac gtagcagaat gtgtaaatat
     7081 aggtgatact aatatagaag aacttttaaa atttgccaaa gaaaatgaaa taggtctgac
     7141 aatagtagga ccagaagtac cactagttat gggaatagta gatgagtttg aaaaagaagg
     7201 attaagagta tttggaccta ataaaaaatg tgctcaactt gaaggaagta aagctttttc
     7261 aaaagaattt atgataaaac ataacatacc tactgcaaaa tataaagaat atacaaactt
     7321 agaagaagct atatcagaaa tagatagttt tggatatcca gtagtaataa aagcggacgg
     7381 attagctgct ggaaaaggtg ttgtaatacc tgaaaataga gaagatgcta tagcaacttt
     7441 aaaagaaatg atgtcagata agaagtttgg agctgctgga gataaaatag taattgaaga
     7501 gtttttaaaa ggaatagaaa cttcaattct agcatttgta gacaatgata caatagttcc
     7561 tatggcaagt gcaaaagacc ataaaaaagt aaacaactat gagcaaggtc caaacactgg
     7621 gggaatggga actttttcac ctagtgaaat atatacagaa gaattagcaa ataaagtaaa
     7681 agagacagta ttagaaaaaa ctttagaagg cttcaaaaaa gatggactta attttaaagg
     7741 tattttattt gttggtctta tgataactga agatggagaa aaagtacttg aatataatgt
     7801 aagatttgga gaccctgaga cacaatctgt tttatttaga ttagaaacag atttacatga
     7861 gataatggaa gctatactag ataataagtt aaaagatata gaaataaact atagtgatga
     7921 tgaagctgtg tgtgttatgc ttacatcagg agggtatcca gacagttatg aaaaagggaa
     7981 aattataact ggtcttgaaa acttggatga tgatatagta gtattccata gtggcactaa
     8041 gatgtttgat ggtaatttgg ttaccaatgg aggaagagta attggtataa ctgcaaagtc
     8101 aactacagtt aaggatgcag cagaaaaagt ttatgaaaac ataaagaaga taaactttga
     8161 aggaatgcac tatagaacag acataggaag ataatttttc taaaatggag gataaggtat
     8221 gttgaatact gaaaataaag actcaatggt tagaagagta ttggttgaaa aaagagaagg
     8281 ttttgacctt gaggctaaag ctttaaaaaa agacttagta gaaagtttac acatagataa
     8341 tatagaaaat ttaagaatat taaatagata tgatgtagaa ggaatatcag aagaagttta
     8401 tgaaaatgca gcaaagacaa tattctctga accaaattta gatgtggtat attatgaaga
     8461 aataccaaaa ttaaatgatg aaagagtatt tgcaatagaa tttcttcctg gtcaatacga
     8521 ccaaagaggt gattgggcag ctcaatgtgt acaaattgta aatcaaggga taagacctgc
     8581 tattaataca gcaaaagttt atatattatc aggcaaaata actgatgaag agttttctaa
     8641 aataaaagat tactgtataa atccagtaga tagtagagaa gcatctttag agaaaccaga
     8701 aacgttaaaa atggaaactg aaataccaac aacagttgaa gtattagatg gatttataga
     8761 tttagatgaa aatggattaa gaacatttgt aagtgaaaaa ggattagcaa tgactttagg
     8821 agacttacaa cacgttcaaa aatactttaa agatacagaa aagagaaatc caactataac
     8881 agaaataaaa gtattagata cttattggtc tgatcattgt agacatacta cttttatgac
     8941 tgaaatagaa aatgtaaaga tagaagatgg taagtttaat gatatagtaa aagaagcgta
     9001 tcaaatgtat cttaactcaa gagacaatgt atatgtgaac agacataaag atatatgttt
     9061 aatggatata gccactgttg cagtaaaaga attaaagaaa aatgggaaat taaatgacct
     9121 agatgaaagt gaagaaataa atgcatgtag tataaacgta gatgttgaag ttgatggtaa
     9181 gatggaaaaa tatctagtaa tgtttaaaaa tgaaactcac aaccatccaa ctgaaataga
     9241 accatttggt ggagcagcta cttgtttagg tggagctata agagacccat tatcaggaag
     9301 aagttatgtt tatcaagcaa tgcgtgttac aggaagtgct gacccaagaa cgactttaga
     9361 agatacttta cctggaaaac ttatgcaaag aaaaataact acagaagctg ctcatggata
     9421 tagttcatat ggtaaccaaa taggtcttac aactgggcaa gttgcagaag tatatgatga
     9481 aaactttgtt gcaaagagaa tggaaatagg tgcagttata gcagcagcac caaaagagaa
     9541 tgtagtaaga gaaagacctg aagcaggaga tgtaatcgtt cttcttggag gaaaaacagg
     9601 aagagatggc tgtggaggag caactggttc atctaaagaa catagtgaag agtcaatctt
     9661 aacttgtagt gcagaagttc aaaaaggaga tgctcctaat gaaagaaaaa tacaaagatt
     9721 ctttagaaat aaagaagttg ctcaaatgat aaaaagatgt aatgattttg gagcaggtgg
     9781 agtttgtgtt gctataggag agattgctga tagcttagat ataaacttag acttagttcc
     9841 taaaaaatat gatggacttg atggaactga gcttgcaatt tcagagtcac aagagcgtat
     9901 ggcagtagcc ataaaaaaag aaaataaaga taaatttata caattagcag tagaagaaaa
     9961 cttagaagct acgcatgtag ctacagtaac agatacagga tatttaagaa tgttctggaa
    10021 tggaaaagca attgtagata taaatagaga gtttttagat acaaacggag taaaacaaac
    10081 tactgatgtt catgttacta aagtagatga agaaaataca ttctttagct ctaatgaaat
    10141 agtaaaagat gttaagtgtg caagtatgaa agacaagttt acaaaagtac tatctgacct
    10201 taatgtttgt tctcaaaaag gattagtgga gatgtttgat aatacaattg gtggtaatac
    10261 agtacttatg ccatttggag gaaagtatca agcgactcca acacaaggta tggttgctaa
    10321 gataccagta cttggaggag agactaatac ttctacaata atgacttatg gatacaatcc
    10381 aaaggtagga aaatggagcc cattccatgg tgccttgtat gcagtagtag aatctgtgtg
    10441 taaattggtt gctattggag gaaattatag tacaacaaga cttacattcc aagagtattt
    10501 tgaaaaactt ggtaacaatc cagaaaaatg gggtaaacca ttctcagcac ttttaggagc
    10561 attttatgca caaagtaaat ttgagatacc tgctataggt ggaaaagaca gtatgtctgg
    10621 tacatttaaa gatattgaag ttccaccaac attggtttca tttgctgttg acacagtaga
    10681 tgcgaagaaa gtagtatctc cagaatttaa aaaagcagac tcaaaagtag taatgttatg
    10741 tgtaaacaag gcagaaaatg atgttgtaga ttttgaggaa ttaaagagaa acttagataa
    10801 agtaagagaa cttatacatg gaaataaagt tttatcaaca tatgcattag gatttgcagg
    10861 tgtaggtgaa gcaataagta aaatggcttt tggtaataaa ataggattta agtttagtga
    10921 agaggctgaa aaagcattta cagatgataa attatttgag gctagttatg gaaatatagt
    10981 acttgaatta gcaaatgatg atttaagtat gttagaagga tacaattatg ttgtgcttgg
    11041 aagtacagtt aaagaagcta gtatatttat caaaggtgaa gaacttgcat tagatgaatt
    11101 atataaagca cattgtagta ctttagagcc tatattccca actaaaacag aagaagtaaa
    11161 atcaaagata gaaactataa gttatatatc acaaggagaa gctaaaaaat catcattaag
    11221 tatagctact ccaagagtat ttataccagc attccctgga acaaactgtg aatatgactc
    11281 tgcaagagca tttgaaagag caggagctaa tgcaagtata agagtattta agaatttaac
    11341 ttataaagac atagaagatt ctatagatac aatagtaaac gaaataaaat cttctcaaat
    11401 aataatgtta ccaggtggat ttagtgctgg tgatgagcca gatggttctg gtaaatttat
    11461 agctactgta tttagaaatc ctagagtgca agaagctata aatgaatttt taactcaaaa
    11521 agatggacta atgttaggta tctgtaatgg attccaagta ttaattaaat tagggttagt
    11581 tccatatgga gaaataagag ttccaagtga aagtgctcca acacttactt acaataatat
    11641 tggtcgccat caagctaaga ttgctagaac tagaatttca tctaataaat ctccttggtt
    11701 agctcaaact aatgttggag atattcataa tatagcaatt tctcatggag aaggtaagtt
    11761 tgttgccagt gaagatgtta tgagagaatt aattgctaat ggacaagtag caactcaata
    11821 tgttgacttt aataatgaag ctacttatga tattgagttt aatccaaatg gttcattcta
    11881 tgctgttgaa ggtataacta gtgttgatgg tagagtgttt ggtaaaatgg gacattctga
    11941 aagaattggt gaggaagtat ataagaatat tataggtgaa aaagaccaaa agatatttga
    12001 atctggagtt aaatatttta gataaagctt tgatgtttaa ttgatagcta gaatatataa
    12061 tttagatatt tagatttaaa gagatgtaat aatatgatga taatcattta atattacatc
    12121 tcttttttat ttatctaaga aataataagt tcaacctaag ttaaaataca agctgtgtta
    12181 taattaatta ttaagtaaaa ttgaatattt attggagggc aacataatta atgaaaatat
    12241 taataacagg gtctaatggt caattaggaa aagaattggt taaccaatta gaagcaatca
    12301 atcaaagtat aaaccaacca aaatatgtta tattagctac aacaagaagt gatttggaca
    12361 tatccaatca gactaatgta gataatttta ttttgcataa taaacctgat gtagttgtaa
    12421 actgtgcagc atatacaaag gttgatgcat gtgaagataa tatcgaaatt gcatacaaaa
    12481 taaatgcttt aggagtgaga aatctagcaa tagcatcaga aaaagttaat gctaagctta
    12541 ttcacatatc aactgactat gtattcaatg gtttttctaa atatccatat agggaagaca
    12601 ataaaactga acccaattct gtatatggaa aaagtaaact tatgggagaa aaatttgttg
    12661 aacaattctc acataagtac tttatattga gaacagcatg gttatatggt aatgggaata
    12721 attttgtaaa gaccatgata aaactttctt tagaaaatac agaggttaat gtggttaatg
    12781 accagtttgg aactccaaca agtacagtag acttagcaaa aattataata aaaatcatgg
    12841 aaacagaaca ttatggagtt tatcatgcta catgtgaagg tgagtgtagt tggtatgatt
    12901 ttgccaaaaa gatatttaaa ctaaaaaata tagatataaa agtaaatcca attaagagta
    12961 acgaatttaa atgtaaggct ccaagaccac tatattctgt attggataat tttatgttga
    13021 agttaattgg tttaaattct tttagaaagt gggaagaatc cattgaagaa tatttagaaa
    13081 gatatgatat aaatgaaaag taaatgtatt attttgagaa aagaaaataa gatattataa
    13141 aaaatataaa tatttctttt atttatccga taatcataat atgacaaaaa caaatttaag
    13201 gatggaaaaa gatgaaagga attattttag caggagggtc tggtacaaga ctatatccta
    13261 taacaaaatg tatatcaaaa caaacacttc caatatacga taaaccaatg atatattacc
    13321 ctatgtcggt tcttatgttg gcagggatac aagatatatt aataatatct acaccaagag
    13381 atataaaagc atttgaagaa ttatttggag atggaagttc actagggctt aacataacat
    13441 atgcaattca ggagaaagca aatggaattg cagaagcgtt tataatagga gaagaattta
    13501 taggaaatga cagagtgtct cttgtattag gggataatat attttatgga tatggattta
    13561 gtgaaaggtt ggagaatgca gttaaaagaa aaggagcaac tatatttggg tatcatgtaa
    13621 gtaatccaaa ttcgtttgga gttgtagaat ttgataagga ttttaatgta ttgtcaatag
    13681 aagaaaaacc tacagttcct aaatctaatt atgctatacc aggattatat ttttatgata
    13741 atgatgttgt agagatagca aagctagttg aaccgtcaga tagaggtgaa ttagaaataa
    13801 cctctataaa cagtgaatat ctaaaacgag gaaaactaaa agtggaactt ctaggaagag
    13861 gtatggcttg gcttgatact ggtacacata aaggtctatt ggatgcttct aattatgttg
    13921 aagtggttca aacaagacag ggactgtata tagcatgttt agaagagatt gcatatacaa
    13981 aaggatatat aagtagagaa caattaatga aactagccaa gccactgata aaaactgaat
    14041 atggtcaata tctattaaaa ttggctagtg aagatatgta atatggtaga taaaatttat
    14101 tataaatttt attaagggag tttattataa tgggaaaaat caatgttata aagactaaaa
    14161 tagaaggatt atatatagtc gaaccaaatg tattttatga tgaaagagga tattttatgg
    14221 aaagctataa taaaaaggat tttatagagc agggtcttga tatgtgcttt attcaagata
    14281 atgagtctag ctcaagaaaa ggcgttttaa gaggaatgca ttttcaggtt aaatatcctc
    14341 aaggaaaatt agtcagagtt acagagggag aagttttcga tgttgcagtt gatttaagga
    14401 aagattcaca aacatttggg aaatgggaag gtgtaatatt gtctgataag aataaaaaac
    14461 aattttatat tccagaaggg tttgcacatg gatttttagt tttatcagaa aaagcagtat
    14521 ttagttacaa atgtacaaat tattattacc cagaatttga gaatggcttt atatggaatg
    14581 acaagcaaat atctattgag tggcctttaa aaggaattga agaaatattt ttatcagaaa
    14641 aggacaaaaa acaaaaaagt tttaaagata tttgtacaag acgttaataa aaatttatta
    14701 gaattaacat ttaggagaaa aaatatgaaa aaaatactga taactggagg agcaggattt
    14761 attgggagta attttataca ttatatgctt aacaagtatg tagattattt tattgttaac
    14821 ctagacttgt tgacttatgc tggtaattta gagacattaa tagaaataca agacaattcc
    14881 aattataaat ttgttaaagg agatatttca aatagggagc aggtgtataa gctatttgaa
    14941 gaagaaaggt ttgatatagt tgttaacttt gctgctgaat ctcatgtaga taggtcagtt
    15001 gagaatcctg atttatttat taaaacaaac attataggaa cacaagtact tttagatgca
    15061 tctataaaat atggagttaa aaggtatcat caaatatcta cagacgaagt gtatggtgat
    15121 ttaccaattg atagaaagga tttattcttt acagaacaat cttctatcaa tccaagttct
    15181 ccatattcag cttctaaagc atcagcagat ttattggtaa gttcttatta tagaacatat
    15241 ggattgttaa caactatatc taggtgttcc aacaattatg ggccatatca ttttcctgaa
    15301 aaattgattc ctcttatgat tttaaatgct ttggaaaaca aacaattgcc agtatatggg
    15361 aatggggaaa atgtaagaga ttggttacat gtatatgacc attgtactgc tatagactta
    15421 ataatacata aaggaaatat aggggagatt tacaatatag gaggtcataa tgaaagaagt
    15481 aatctagaag tagtaaaaat gatattaaat cttttaggta aatctgaaga gttaatatcc
    15541 tatgtaaatg atagacctgg tcatgattta agatatgcta ttgatgcaac taaaatagag
    15601 aatgagttag gttggaaggc aaaatatgac tttgatttgg gtataaaaga aactgttaag
    15661 tggtatatag aaaatgaatc ttggtggaaa gctgttttat cagtataact ttaaaattta
    15721 gaaaggggcg ttttatattg aatgagataa gttcactaat taatatatta gcattgactc
    15781 aattatctgg tagtaatact acaaatcaat gtaattgtac atataataat tcatctggat
    15841 ttgatatgat tatgatgacc ttgttaaaag cattatcaca aaataatcaa catacttcta
    15901 atagctacaa tttattgtct aattctgaga atttatttaa tgaacttgat aatgtagtaa
    15961 ataataccac tagtagattt atagatgttg atacaaaaga taaaaatgta aagttgagaa
    16021 ttgaaaatgc tgtagatcaa gcatcaaaaa aatataacgt agattcaaat cttataaaag
    16081 caataattaa agttgaatca gattttaatc caaataccgt ttcttctgct ggtgctaagg
    16141 gtcttatgca acttatgcca gaaaactgca gagacttagg agttacagac ccttttaata
    16201 tagaacagaa tatagatgct ggaactagac atattaagga atacattgat atgtttggag
    16261 ggagcataga aatgggattg atggcatata atggtggtcc tggaagaatg aaaagtagag
    16321 gagtagaatc aatctctgac ctgtataaaa tgccaaaaga aacacaaaat tatattccta
    16381 aggttatgaa atattataga gggtaggctt tattatggga ataaatatag ataagctaaa
    16441 cataagtcca agtataaata tggaggttaa aaaactaaaa gagagtaata aattttctga
    16501 caaattaaac tctttaaaac aatcttcttc attggaagat ataaaacgaa atttggaaag
    16561 tgtaaaaaag gcaggagaaa ggcttgtact tactcaaaac tatggcgata ttagtatata
    16621 taaaaatgca gtaaaagaat acctaaaatc tgttgtagat aatatgtatt cacttgataa
    16681 aaatagtagc ttttgggagc atcagtatta taagaatgta aagattgttg atagtaaact
    16741 tgaggatatg actagtaagt taattagtga agaaaaagaa aacatagata ttgtttctac
    16801 tgttgacatg atacaaggct tattgataga tatgtataga taaggttata caaggagaaa
    16861 aattttatga atagcaaaaa agaggatata tatgaattga attttgggca attaatagaa
    16921 gaaaaatctg gtgttataga agaaaatcaa aatgttttta atgcaaaagt aaatgtagct
    16981 gtttctatag gaaatacaac agaaacaata aaaaatatat tagatttaaa agaaggctct
    17041 ataataaaat taagtaagaa tgtggatgaa aaattagata tatatgcaaa cgatagattg
    17101 tttgcttatg gagaaagcat tattacaaat gagaggttat ctgtaagatt atctaaaata
    17161 gaagatccag atgtaaatta gcattttaaa tagtatccct ttaggctatt ctgtatgagt
    17221 ttagctaagg ggatattttt ataaaaaatt taaaatatgt gtgaattata taaatatttt
    17281 tattttatga gcgataacta aattataagt atgtaatttt ggaggtgaaa ctatggatat
    17341 taaaaatgta agttcaaata ttgtagtgaa taattattta aagaatacat ctggtataaa
    17401 aaaagtggaa gaggttaaaa aaattaataa aacagacaag atagagttat ctaaatttgc
    17461 aaaggaaatg gcaagtgtgt caaatatgag tgatgagaat attagaaata aaaaagtcga
    17521 tgaaataaaa aatgcattag aaaatggaac ttacaaaata aaaccaaaag aaattgcgaa
    17581 aaaaatgata gaggatatgc gaggataaag tcatgattac agacttaaaa gttataatat
    17641 atgaagaaaa aaatataatt agtaagatga tggaattatt aaaagaacaa tttgattata
    17701 tagttgaaaa agacttagaa aatttaaata tgttaaatcc taaactagaa gatattagca
    17761 gggagcttgc atccatagaa ataaagagaa gacaactttt tggtgatgat atttcaatga
    17821 gtgaagttgt tgaaaatagt aatgatggat acttaaaaga aatatataca gacttgaaac
    17881 acattcttgc tttagctaaa aatcaacaag aatcaaatga ttctctaata aagaaagaac
    17941 ttatttttac gaaaaaaatg attaatttca taaaaccagc tgataagcaa actacaactt
    18001 ataattctta tggaaatatt agaaaataaa tattaggagg agaaatatgg caggattatt
    18061 ttccatttta aatacagcta attcaggaat gaatgcgcac caaaaagcaa tacagacaat
    18121 ttctcataat ataagtaatc tagatacaga cggttattct aggcaaagga ccgagtttgc
    18181 cacaaatagt ccaatgtata tgcctagttt gagtaattca attgcaagag gacaattagg
    18241 gactggagta catgtaacgg atgtaacaag agctagaaat agtttttatg attaccaatt
    18301 tagggcagaa gctcataagt atggtaagac agtttcaaaa tatgattatt acaatactat
    18361 agaaactata ctaaatgaac catcagacta tggaatatct gcaggtatag atgatttttt
    18421 taaaggatgg gagtcattat caaaggatat aaatagtgac agtaaaaaaa gtctagtggt
    18481 agaaaacgca tctaatttag caactttaat aagtgaaagt tataagaagc ttgataagtt
    18541 aaaagaagat atagattcta atatagacac tgagataaaa caaataaatg acatgttaaa
    18601 aagtcttgaa gatttaaata aatctattga tattatatct ggttctggct ctacaccaaa
    18661 tgatttactt gatgaaagag atagaatttt agataacttg agttttaaac tagactttga
    18721 aaatagtgat gttaaaaata tgcttgcaga tggtaaatta gaacttaatg aattaaaaaa
    18781 tccagatgga acttggaaaa caggtatatc agggacctta caaggcttgt ttgaaatgca
    18841 tggtaagatt gatacatata aaagcgattt aaaagatgta tctgatggat tagctaaaca
    18901 gataaatgat gtttataata cgtctgcagg aataacagta acagattttt ttataacttc
    18961 aaatgtagat ggtgaagata ttataaagat aaatccagct ataaagagta acccaaatga
    19021 attaaagctt actgctgatg aagcttcaaa aattgctaag ttaaaggatg aaaaaataga
    19081 tattggggtg gctggtggaa aagtaagtac aataagtgac cactataaag cctttgcaga
    19141 atcaatcggt ttagattctc aaaaagtaaa tcaagatgaa gcaaatcaac gtaaaattat
    19201 aaataatatt gataactcaa gaatgagtgt ttcaggtgta tctttggatg aagaaatgac
    19261 agagcttata aaaatacaac gttcatatca agctagtgca aaagttatgt caacagctgt
    19321 gcaactattg gatgttgtaa taaatggaat aatttaatag aagggggaat ttataatgag
    19381 agtcagtaca ggtatgatgt ctagcagcta tctaaactca ctacaagata atctacaaag
    19441 attggataag gttaatagac aagttaatac aacaaaagaa ataaacaagc tatcagataa
    19501 tccatataaa gcaataaaga tattaaactc aaaaagtgaa ataaagacta tggagactta
    19561 tgttgagaat tgtaaagata cagggaattg gttagaaact actgatactg cattagatca
    19621 gcttggaaaa ttattatcag acataaagaa aactttggtg gcaagtggtg atggtgcata
    19681 ctcagatgat gaattaaaga ctcttagtaa tgaaactaat gaaaaaatga aagaaattgc
    19741 aaatgcttta aatgcaacac atgaagggaa gtacatattt tcaggttcaa atacgggggt
    19801 accacctgtt gaatgtatag ataatgctga tggttcagtg agtttaaagt ttaattctag
    19861 tctaaatctt aataaattaa atgactcttt gagtatggat atagctcaag gaataagtgt
    19921 agattataac gttaaattga gtagccttgg atttgaccca acaaaaactg acccatttga
    19981 agagttaaat aacatatcaa aaaaattagc aaatccagat gctgatgcta taaaagagct
    20041 tacaacaact tgtttgggcg atatggaaca actaatagaa aatacagtaa atgttaggtc
    20101 tatatatggg acaaaagcaa atacagtaga ggctatgaag gaaaaaaacg atgatagttt
    20161 gatacagtta aaggatattt tgtcacaaaa tgaagaaata gattatggtg aaaaacttgt
    20221 tcaattaaag gcagcagagt taacttatca agcttcacta caaacaggag gaaagttatt
    20281 taatgtatct atattagatt acatatagta aaataacgca gatatgatga aggttacatt
    20341 aaaaaaaggt atattaggtt ttgaaaattt aaaagaatat gagcttttag atatagaaga
    20401 taatgattct ttaaaagaat ttaattctac tgaagaagaa ggtataggat ttgttgttgt
    20461 atctccattt gagattatca atgaatatga aatagtttta aatcaggaaa caatagaaaa
    20521 actagaagtg aaatctccaa aggatgttgt actatttaat ataattactc ttggtcagac
    20581 atttgaagaa tcaactgtga acatgaaagc tcctatagtg ataaatataa aaactaattt
    20641 tggaatgcaa ataattttac aggatgataa atattcaata aggcatccat tattgagagg
    20701 tgataatgga tgctagtaat ttcaagaaaa aaagatgaag cagtacttat aggagaaagc
    20761 atagaagtaa aaattgtagg ggtagatgga aacaatgtga aactagctat atcggcgcct
    20821 aacaatataa gtatattaag aaaagaaata tacgaaaaag taaagagtga gaatataaaa
    20881 gctacaaata aaaatataaa aattttaaag tcattaaaat aataagcttg gaggaagtaa
    20941 tatatgtatg gagaaaatcc ttataattct tataaacaaa atgctgtttt tatggcatca
    21001 aaggaacaat tgttacttat gcttgttgat ggagcagtaa aatataccaa aatagccaga
    21061 gcagctatct tagataaaaa tacacagaaa gcgcatagag aacttgtaag agttcaggat
    21121 atatttacag aactaatggt tacattagac caaaatgcag gacaatgggc aaaggatatg
    21181 tacaaagttt atgattttgt aagatatgaa ctttcaagag ccaatattag aaaagacatc
    21241 caggtaatag atagtgtgtt gcctgtaata gaacaaatta aagatacatg gcatgaagct
    21301 gataaaaaaa gtaaagaaga aagaagtagg gacaaataat ggaattaaat ttagctgaat
    21361 tagataagtt atcaaaagag gaattactat tgatgcttgt agatggcaca gtaaaatata
    21421 ccaatatatc caaagaagct cttttaaata acgactattt gaaagcacat aatgaacttg
    21481 taagagttca aaatatattt acagaactaa tgactacatt agaccaaaat gcaggacaat
    21541 gggcaaagga tatgtataaa gtttatgaat ttataaaatc tgaattagca atagctgatg
    21601 aaaataaaga tattaaaata attgatgata tattgccaat agtaaaacaa attagagata
    21661 catggcatga agtttacaat caactaaaaa tataattaga tggagggata aaggtatgtc
    21721 aagtataagt cctataagag ttacaggtct ttcaggaaat tttgatatgg aaggcataat
    21781 cgaagctagt atgattagag acaaggaaaa agttgataaa gcaaaacaag aacaacaaat
    21841 cgttaaatgg aagcaagaaa tatatagaaa tgttatacaa gaatcaaaag atctttatga
    21901 taaatatcta agcgtaaatt ctcctaatag tatagtaagt gaaaaagcat actcttctac
    21961 aagaataacc agttctgatg aaagtattat agtagcaaaa ggttcagctg gtgcagaaaa
    22021 aataaattat caatttgcag tttctcaaat ggctgaacca gcaaaattta ctattaaact
    22081 aaattcaaat gaacctattg ttcgacaatt ccctccaaat gctagtggag ctagttcttt
    22141 aactatagga gatgtaaata taccaatatc tgaacaagat actacaagta ctattgtaag
    22201 taagataaac tcactttgcg cagataatga tataaaggct acttatagtg agatgacagg
    22261 tgaattgatt atttcaagaa aacagactgg ttcgtcatca gacattaatt taagagtaat
    22321 tggaaatgac aatttggctc agcaaattgc caatgataat ggtatcacat ttataaatga
    22381 tgctggtgga aacaaagtgg caagtgtata tggaaagaat ctagaagctg atgtaactga
    22441 tgaacatgga agagtaactc atataagtaa agaacaaaat tcatttaata tagataatat
    22501 tgactataat gtaaattcaa aaggaactgc aaagttgact tctatcactg atactgaaga
    22561 agctgttaaa aatatgcaag catttgtgga tgattataat aaactgatgg acaaggtcta
    22621 tggtttagtt actactaaaa agccaaaaga ttatccacct cttacagatg cccaaaaaga
    22681 agatatgaca actgaagaaa tagaaaaatg ggaaaagaaa gctaaagaag gtatacttag
    22741 aaatgatgat gagttaagag gttttgttga agatattcag tctgcatttt ttggagatgg
    22801 aaaaaatatt attgcattaa gaaaactagg tatcaatgaa agtgaaaatt acaataaaaa
    22861 aggtcaaata tcatttaatg cagatacttt ttcaaaggct cttatagatg atagtgataa
    22921 ggtatacaaa acactagcag gttattcttc gaattatgat gataagggaa tgtttgaaaa
    22981 gctaaaagat attgtatatg aatattctgg aagttcaact tctaaacttc ctaaaaaagc
    23041 aggtatagaa aaaactgctt ctgctagtga aaatgtatat tcaaaacaaa ttgcagagca
    23101 agaaagaaat ataagcaggt tagttgaaaa aatgaatgat aaagagaaaa gactttatgc
    23161 taaatattca gccttagaat ctttgttgaa tcagtattct tcccaaatga attatttctc
    23221 acaagcacag ggtaattaat tatggataaa ttaaaagaaa aattaaattt atataaagat
    23281 atatctttac aaattataaa tttgattgaa aaggaagaat atataaagat aagtattaag
    23341 ttaggtgaaa gacaagagat tataaatagt gtaagtgaaa ttgatagaaa tgattttata
    23401 cagctttata atagaatgga attaattgaa attgatagca ggataagaga tattttacaa
    23461 ggacaattat tagaagtaaa aaaagaatta catgagtata agcttactaa acaagtgaac
    23521 acaatgtatt ataacttaaa tagagaaaaa gtaaatattt ttaataaaaa agtataaagt
    23581 tatgtaccat cttgtccgat tatataaatg aagaattaat aaaaaagatt aaaagtagaa
    23641 atgacaagga tgtcaactat actaaggagg gtaaaataat gagagttaat acaaatgtaa
    23701 gtgctttgat agcaaataac caaatgggaa gaaacgtaaa tgcacaaagt aagtctatgg
    23761 agaagctatc ttctggtgtt agaattaaga gagctgctga cgatgctgct gggcttgcta
    23821 tatctgaaaa aatgagagct caaataaaag gtttagacca agcaggaaga aacgttcaag
    23881 atggtatatc tgttgtacaa acagcagaag gtgcattaga agaaactggt aacatactac
    23941 aaagaatgag aactttatca gtacaatctt caaatgaaac taatactgct gaagaaagac
    24001 aaaagatagc tgatgagtta ctacaattaa aagatgaagt tgaaagaata tcaagctcaa
    24061 ttgagtttaa tggtaagaaa ttacttgatg gaagttctac agaaataaga ttacaagttg
    24121 gagcaaactt tggaacaaat gttgcaggaa catctaacaa caacaatgaa ataaaagttg
    24181 ctctagtaaa tacttcaagt ataatgagta aagcaggtat aacaagttct acaatagcaa
    24241 gcttaaatgc agatggaact tctggaacaa atgcagctaa acaaatggta tctagcttag
    24301 atgtagctct taaagaatta aatacatcaa gagcaaaatt aggggcacaa caaaatagac
    24361 tagaatcaac tcaaaacaac ttaaataata ctatagaaaa tgttacagca gctgaatcaa
    24421 gaataagaga tacagatgtt gcttcagaaa tggttaactt atctaaaatg aatatattag
    24481 ttcaagcatc acagtcaatg cttgctcaag ctaatcaaca accacaagga gttttacaat
    24541 tattaggata aaataatttt gtatattgga tatagaagaa agggtaaggc tttgctttac
    24601 tcctttcttt ttttacaaat atacttttga aaggaaaatt tatatgttac ttagtatagt
    24661 tatgattgtt aaaaatgaag aaaaaatact tgaaaaaact ttaaaatcat taaccacatt
    24721 aagaaattct atagaaagtg aacttataat agtcgataca ggttctacag atgatactat
    24781 aaaaatatct aagaagtaca cggaaaaagt gtattttcat aattggaata atgatttttc
    24841 tagtatgaga aatatatcaa tatcctatgc taaaggtgaa tggttactta tattagatgc
    24901 agatgaaata ctaattgatt cttcaactat tgtaaaattt tttaaagatg gtcttgataa
    24961 aaaatttaat tctgcttcaa tacaattaaa aaatctttac tcatatgata aaaaattata
    25021 tggatattgt tcagtgctta gactttttaa aaacgttgat tttagatacc atggtaaagt
    25081 acatgaacaa ccaatataca aaaaccctat atttaataat gttgctgatt ttgaacatta
    25141 tggatatttg tttgaagatg aagaaataag attaaataag gtgaaaagaa atgaaaaact
    25201 attatttcaa gagttaaaag agaatgataa ttctccatat acaaactatc aattagggaa
    25261 aaattttatt atattaggaa aatatcagga ggctttatac tatcttgaga aatcttatga
    25321 attatattct aaactagaat tggcacctgg ttacttgata acaagccttg taaaaacata
    25381 tttatattta ggaaaacata agaagtgtga aagattgtgc ttaaagtata ttaagaaaga
    25441 catgaataat attgatatat attattatat tgcacaagca caagtagatt taggaaagta
    25501 tgaaaatagt atagattcgt ataagagata tatttacttg ttagataatt atgaaataag
    25561 tacacaagca aatagtttat tttcagacac tgatactgta gggcttagag atgaggctat
    25621 tattacactg ataaagattt attataagct tgaaaaatat gagtttgtaa tttcagagta
    25681 caataacatt gaagatgtgg aaaagaaaaa gaatgtgtac tttagcttat ttatgtccct
    25741 atataaattg aatagatttg aagatataaa aaattattat aaagaagttt caaattctaa
    25801 aattgaaaaa aatagttttt atagaaatat agaagaagtt ataaataata ttaaagagga
    25861 tgaaaaagag tatgtatata aaatcctttg tgacattgaa ggtaattatg gcattttaaa
    25921 tcaaataagg ataaataaat gtgtatctat agataaatgt aaagaaatac taaatgaaga
    25981 aaaggaaata atttatgcat atattataaa aatagctttt gaagagaaga ttgatttact
    26041 agatattttt tatgaaatgg aatatgtatg gatagagaaa tatctaaaat atcttttagc
    26101 attagaaaga agttttaatt tagtactata taagtacata attagtcgtc caaatacatc
    26161 agatatggaa aagataagag tatataaagc tatatctaaa gtagttttag aaagtataag
    26221 cttaagtgat gaaaaatata aggagatttt ttatttttat ataatgtatt cttataagta
    26281 tataagatac atatatagca atttaagtga ttttgaatta aaaaaatttg tttgcaatga
    26341 tttagataag ttcactatag aatttaagca tctacttgac attaaaaata aagtaaataa
    26401 tgctaatgaa aaattagagt atatacatag tatgaggaaa ttactaaatg agtatccttt
    26461 ttataataaa ataataaaaa tacttatagg tgaattagaa gaaaatataa aagaaagtga
    26521 agaatttaag gatttaaaat atagttttat tattagtata gaaaatatga ttgaaactgg
    26581 caaaataaat gatgcgaaat tattggtaga tgactattca aaaacatttg tggatgatgt
    26641 aaggatttta aatataaagg gaattttata tatgtttgaa aataagcttg ataaagctga
    26701 ttttatgtta aaaaaggcat tatcattaga tgtagaaaat gaagatacta tatataatat
    26761 agaatactta aaaagtttaa gataagtcaa aaataggaga attgaagaat gaatatacca
    26821 atagtggtta atgaaaaatc taaagacata ataaaagatt ggcaatatac atgtacaaat
    26881 gaagatataa aatttacaag cataataata ttgacatata atcaaataga atatactaaa
    26941 ttatgtattg aaagtattag gaaatttacc ccaaagaata aatatgaaat aataataatt
    27001 gataataact cttctgatgg aacagttgag tggttaaagg gacaatctga tataaaatct
    27061 gtgtataata acaaaaactt aggatttcca aaaggatgca atcaaggtat tgagttagct
    27121 actggtgaaa acatattgtt gttaaataat gatgtaatag ttactccaaa ttggctctat
    27181 aatttgaata aagctttatg gtctcaagat aatataggtg ctgtaggacc tattacgaat
    27241 gcatgttcat attatcagca aattgatgtt gattataagt caattgagga catgtttata
    27301 tttgcacaca aaataaataa atctaatatt aacctatgga aatatagatt gaagttagtt
    27361 ggattttgca tgttaataaa aaaaactgtt ctggataatg taggggtttt agatgaatta
    27421 ttcacacctg gaaattttga agatgatgat ttatctttta ggatgataga gtcaggatat
    27481 aagttattat tatgccagga tacttttata caccattttg gaagtgtgtc ttttaaagaa
    27541 aatcgtaata aatatacaga tataatgtat attaatagaa gaaaatttga aactaagtgg
    27601 ggatttaatc cagaatatag tggaatgata agaacagatt tgatttctaa aatagatgat
    27661 agtttggagg caaatattaa tgttttagaa ataggatgcg gtataggggc tactctttta
    27721 gaaataaaaa atatatataa aaatgcatca atatatggaa tagaaattag tgagtcagca
    27781 ggtaaacttg caaagtatag tgcagatgta cttatagcaa atatagaaaa agtaaaattg
    27841 gattataaaa aagatttttt tgattatata atattgggag atgtacttga acatttgatt
    27901 gacccatgga agatagtcaa tgaattgaaa caatatctaa agaaggatgg ttatctggta
    27961 tctagtatac caaatattat gcatgtttct gttttaagaa atcttgtgtt aggtaatttt
    28021 acatatgaag attcaggaat tttggacaag actcatttaa ggttttttac attaaatgag
    28081 ataacaaaaa tgtttaatga tagtaattac ataattaata gtattacagc tactagtatg
    28141 ccactttcgg aaattgataa tagcttcatt gatacaatat gtaaggaaag ctgtaaagaa
    28201 atgagacaac agtacgaatc ttatcaatat atagtaaaag cctctaaaat cctagatact
    28261 aaaagatatt ctagtattag tatgattaat ttaaaatacg ctttaatgag aattgataat
    28321 gaattagatg tagatagtaa tttaagttat atatttgata attataatat aactgaacca
    28381 tgttttgttg atgatattga atatctaatt gatacatttg tgataaataa agcaactcta
    28441 ttaaatagat taggagttga ggcatttaac agaggtctag gagattttag tataaacatg
    28501 tttatgacag tattagagat ggatagagat gatattgact caatatataa tataacaagt
    28561 gtattatgtg aattagaaga atttgatact gcttataatt taattaaaaa tagtagcgaa
    28621 aaagtacaga gtgaaagtga tatacaagag atactttgtt ttattgaggg gaagaaatat
    28681 gaataatgat aagatatgtt ttataacctg tgtaaatgat gaaaggcttt atgaagaatg
    28741 tcttgtatat ataaatagcc tagacattcc taaaaacttt agtatagaaa cagtagcttt
    28801 aagaggagcc gattctattg cctctgctta taataaagct atgagagaaa cagattctaa
    28861 gtataaggta tacttacatc aagatacttt tataattaat aaaaatttca tacatgatat
    28921 tttagagata tttaaaaaaa atacagatgt cggaatgatt ggtgtagctg gagtaaaaga
    28981 tatgcctgtg aatggaattt ggtgggattc tgataaaaaa gcagggaaag tatatgatag
    29041 tcatacaggt aaaatggata tttatgaatt tagtaacttt gaagaatgtt ttaatgaagt
    29101 tatggctata gatggattaa ttatgattac tcaatatgat gtattttgga gagaggataa
    29161 gtttgatggg tggcattttt atgatttgtc acagagtatg gagtttagac aaaataaata
    29221 caaagttatt gtaccaaaac aaaataagcc ttggtgtatg catgattctg gagtagtaaa
    29281 tataaataat ggatatgatg aatataggat aaaatttgta aaagagtaca taaatcttga
    29341 tttatataga gaaaattttt atgaatttga taagaagaaa gcaagtacca tacttaagag
    29401 taataagcat gtaatggatt gtatgaaaga ggagcttaca gaacaattaa gattaaagaa
    29461 ttacaaggat gttttaggta ttgtttctaa aattgctcat ttttctgttt ttaatcatac
    29521 tggtttgtat tcttgtgaag aatgtgagag agcattgcta gaatgtgcaa ataatttacc
    29581 agaaatagaa aatacgaaat tatttacaaa aaaagattta aaaagaagaa aagtattaca
    29641 tgttttaagt gaaggatatt caacaggagg tcatacaaga ctagttaaaa attggattga
    29701 aattgacaaa gactctgttc attcagttgt aactacatgg caatcagata cactgccaga
    29761 ctggttatta aaagcaataa atgatagtgg tggcgaagtt atatctttgg atttaatttc
    29821 agatgattat ttaaaaagag ctgtagcttt gaggaaaata gcttatgact gggctgatat
    29881 agttatttta tatgttcata tgtgggatac aatacctgtt gttgcttttg gagttgatgg
    29941 gaaaatacct attttacatg ttaatcacta tgatagtact ttttggttag ggacaagtat
    30001 tgcagatatt gtcattgatt ttagcgaaac tagtcaatta attacattag ataaaagagg
    30061 catagataaa tctgaaatat taccaatgcc attaaaagaa aaagaagtat tttcaaaatc
    30121 tgaagttaga aaacgatata atttagagga tgatgtgaca ataatattga ctattgctag
    30181 tgaaagaaaa tacaatagtg taaatgatat taattacttt aaaattgcta aaacattgat
    30241 tgaaaataca gataatacaa ttattattgt tgtaggagtt gatacagaga atctctattg
    30301 gaaaacttta agtaatgtta cagataatag agttatatgt tttggaacaa cagcaaatat
    30361 agatgatttt tataagattt cggatatata cctagagtct ttcatggtag gaagtcatac
    30421 ttcaaaatta gatgcaattt tatatgattt aattcctgtt aagtttaaaa atgaagtttc
    30481 accaattttt acaaatatgt ggaattttat agataagttt gattataaga atataaaaga
    30541 ggttatagac atgataagaa ggtacaatac tagtgaattt gacagggata agataaaagc
    30601 aaaacaatcg gaaataaaac attttgttat agataaacac tgtattgaaa taaaaaacta
    30661 tatagacaaa atatataatg aagttaatca tcataaagtt aagtatgatt tatataaaaa
    30721 tgatgaaatc gaggactatc agctttttgt agcattatat ggctatatgg taaaaaataa
    30781 aaacatgtca taggtggtaa aatgaacaat attcatatca ataaatttga aaaaagctgt
    30841 gaaaaaaact gggattattt tgtagaaaat aaatctataa atggtacatt tctgcaaact
    30901 agaaatttcc ttaattatca tgaggaggga aaattcactg accactcatt aataatatgt
    30961 aaaggtgaag aaatactagc agtcgtacct gcatgtgaaa cttatgaaga tggtgaaaga
    31021 atattttttt ctcatttagg gagtactttt ggtggcatta taataagaag tggttttaat
    31081 gatattaggc atgtaaatgc cattacaaat aagttagaaa tatatttaca ggaacaaaat
    31141 ttcgataaag tatatttaaa aaatacatca agaatatttt gtaaagagga tacttcatta
    31201 ctagaatatt ttttatttaa gaataattac atgttttatg atgaattaag tatgttttta
    31261 gaattaagta agtataaaga agatatatta gccaatttta aatacagtaa aagaagagat
    31321 tttaaatatt ctttgaagaa taatcttacc tttaaaagac tgtatagtga tgaagatata
    31381 gtttgttttt ttaatttact ttctaattgt ttagatagta aaggagctaa agtaatacat
    31441 tcagtagaag aacttttgga gtttaaaaat aatagattaa aagatattgt agaattttat
    31501 gcagtatata ttgatgacat tatgatttgt gggagcatgg tatttaactt tcaagaaaga
    31561 gtttatcata ctcaatatct agcatcaaat tcgacatata ataaatatta tccaatgata
    31621 tttttatact ataatctaat aaaagatgct ttagagagaa attttaagta tctttctttt
    31681 ggaattagca ctctaaatag aggcaaatac ttagatgagg gtttagctac atttaaagaa
    31741 ggttttggtt caagtgcaat ttgtaacaga acatactata aaaatataaa taagtgagaa
    31801 tcatgtttta tagagttttt agagtatagt aaatatctag tactataata ttacataaaa
    31861 ataattagtt tataaagaag gtttgtatat gaaaagatta atgattttag gctcaattaa
    31921 gtattttgag aatattgtta tgtcagctaa aagagaggga atatacacaa ttgtttgtga
    31981 taatagaatt gatactcctg cgaaaaagat ttgtgatgaa gcaatagatg ttgatgtatt
    32041 tgattttgat aaaataaaga atatagctat agataaaaag atagatggaa ttttaactgg
    32101 atttacagat tctttaatga agccatatgt ttatattgca aatgaactaa atttgccatg
    32161 tgtgatttct tgcaatcaac ttgaatctgt aactaataag gctgttatga aaaattattt
    32221 taaaaataat ggaataccta caactgatta ttgtattatt gaaagtttga aagatttaga
    32281 aaaaatacaa ggattaaatt ttccacttgt aataaaacct gttgatggtt atggttcaag
    32341 aggtgtatat tttgtatcaa acatagaaga attaatagaa aaatttgaat attctaagga
    32401 agcctcgcaa gatggacaag taataattga ggaattttat gaaagtgagg aaatacaagg
    32461 actagcttgg gttcataatg gagagtcaca tgtattttat attggagata gagagcttgt
    32521 aaatatacat acaggaagag ctggaaaacc agatagatta atttatccat caaagtattg
    32581 ttttcaatat gaagaagaaa taaaatccat atatcaaaat ataacgcagg cttttggcat
    32641 aaaaaatgga cctctttatg tacaaatgtt agtgggagca tatggaataa aggtatctga
    32701 agtaatgcca agattacctg gaggttgtga ctatatggct atttctcaaa taacagattt
    32761 agacatagga agtttatttg caaactttag tgtgaataat gaagtaaatt ttgatgaaat
    32821 aaagaaatat aatatgcatc tatcaaaatg tgtatatgca ttaccaatat acataagacc
    32881 tggcacaata aaaaagataa ataatataga taaaatagaa aacttagatt atgtcactca
    32941 atttctatta ctagtaaaag aaggagatac aataggatta tatgaagatg agagacagga
    33001 ttgtggaaga gtttatggag tagcaaataa tgtatttgat gcaaatataa agaagaaatg
    33061 tattcatgaa atgatagaaa tacttgatga aaataatgaa aatatgatag aaaattttta
    33121 aataagggag tatgatagat atgaagctaa taactcatga acaaattatg tcattaaaca
    33181 tttctcagaa acaaggatac gagtggataa aagaatcctt tttaacaaaa aaagattgtc
    33241 aattaccacc aaaaataagc atggtagaag aagggcatgt attttacaat gtaatgccgt
    33301 ccctaaatca taatcataag attggtggaa taaaaatggt tacaagattg ccagggagaa
    33361 atccaagttt aaattcagag atatttctat ataatatgga agatgctaaa ttaaaggcta
    33421 ttttagatgg caattatatt acagctttta ggactgctgc tgttgctgcc ttggctatcg
    33481 atacatttgc taaaaaagat tttaatacta ttgctattat gggtttaggt gtaactgctt
    33541 ctgctataat gaatatgctt tcatatactc ttaaagataa aaatataaat ataaagttac
    33601 ttaaatataa agaccaagca gagtcgtttg taaaaaagta tgaaaaaaat gaacaattta
    33661 gttttgaaat atgtgacaca catgaagaac ttattgtaga ttcagatgta gttatttcta
    33721 ctgtgacata tacagatgaa tatttatcag aatttaaatg gtttaaaaaa ggtgctttat
    33781 tattacctgt acatgttatg ggatttggaa atgttgatta tctatttgat aaagtatatt
    33841 tggatgatta taatcatttg aaacatctag aaaatataga tagatataaa tattcttgtg
    33901 aattttatga tgttttaagt aaacaagcta aaggaagaga aaatgatgat gagagaataa
    33961 tatcttacaa tataggtttg tcaatacatg atatattatt tgcaaataaa atttacgaat
    34021 tgtgtgaaac actaagctgt gaagaaatag aattaaaaga accaaaagaa aaatattgga
    34081 tatagtttat ttcattcata tttacaatag tttattgtaa atatgaatat gaagtaatat
    34141 attgttagaa aattagcatg aataggatag ataaatttat ggataaatat aatttaatta
    34201 ggttcgtatc tattggaaac gaatatatag gaaatttagt tgcattagaa tcaaataaag
    34261 caataccttt tgatataaag agagtttatt acatatatga tgtaccaaac aatgtaaaga
    34321 gaggatttca tgcacacaaa aacttggaac aagtactagt ttgcctaaat ggaagtgtga
    34381 agataaaatg ttatgatggt gtaaaagaga ctatatttaa tttacataaa aatgatgttg
    34441 gattatatat aggaacggga gtgtggcatg agatgtttga ttttgatgaa aaaactgttt
    34501 taatttctat agcatctgaa cattataatg aagaagatta tattagagac tataaagaat
    34561 ttttaaagta tttaaataat gtgtagttat tatacaatta gtgatgtatt ttcttaatta
    34621 aataaattta agatagccac atagagaata gatagattag gatgtgaatt tattgttggt
    34681 taaatttaat aatttattaa aacagttcca aactcataaa gaagaatatg aacagaagat
    34741 taaggatgta atggaaagtg gatattatat ccttggaaat gaagtaaagc attttgaaga
    34801 agaatttgct aactatgtag gtagcaaata ttgtgttggt ttagccagtg gtttagatgc
    34861 actgataatt gcttttagag cattaggaat aagcaaaggt gatgaagtaa tcgtgcaatc
    34921 aaatacatat attgctagtg ttatgggaat cagtataaat ggagcaacac cagtatttgt
    34981 agaaccaaat gaatattata atatagattc atctaagata gaagaaaaga taaatagcaa
    35041 aacaaaagct atattagtag tgcatttata tggtcaagca agtaatatga aagatataca
    35101 agaattatgt gataagtata acttgtattt aattgaagat tgtgctcaat ctcatggagc
    35161 taaatatgat ggaaaaatga caggaacatt tggtgatata ggttgtttta gtttttatcc
    35221 aagtaaaaat ttgggtgcat ttggagatgc aggagctata gtaactagta atgaggaaat
    35281 agctgataaa gtgaaaattc ttagaaacta tggctcagaa aagcgatatt ataataaatt
    35341 tgtcggatat aattcaagat tggacgaaat tcaggcaggt ttattaagag taaaacttaa
    35401 atatctaaat gaaattgaaa ttgaaaaatc aaaaatcgta gatagatatc ttaatgaaat
    35461 taataatccc aaagtcatac ttccaaagat agaaaataat tgtactcatg tatggcattt
    35521 atttgtttta caagttgaaa aacgagatac atttatggaa tacttaaaga aaagtggtat
    35581 agagtctata atacattatc cgataccacc acatctatct gaagcatatg cttatttggg
    35641 atataaaaag gggagtttta atatagctga gaactattca gataaagttg ttagtatacc
    35701 tttatttatt ggtatggaag atgaagaagt tagttatata attaaaatta
//
LOCUS       DAEQCW010000031        35716 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.031, whole genome shotgun sequence.
ACCESSION   DAEQCW010000031 DAEQCW010000000
VERSION     DAEQCW010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 35716)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35716)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35716
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.031"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..768
                     /locus_tag="KRO40_001537"
     CDS             <1..768
                     /locus_tag="KRO40_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1648 domain-containing protein"
                     /protein_id="HBH2092358.1"
                     /translation="LKSEIYSKLGHIDIDSKLIVDMDFINKKNKIIKKFKIIYLIPIL
                     FTLGMSIFIAFNYNQLPDSIATHWNINGSPDVFIDKSFLNVFKLIGTDFCLMVLLYIT
                     SIGSIKSRIKIDTNRIEESRVENIKYLNKIGYLFLILMIIMTTQFFTTLLSIKTKLST
                     AMNITTLLVIIYLIATYINSPNLKFNSSYSPEEDEKYWIAGIMYNNPNDPSLMVNKRF
                     GIGWTINFGNPLGKILYIAIALLLIFSLFSLIKSLLL"
     gene            888..1364
                     /locus_tag="KRO40_001538"
     CDS             888..1364
                     /locus_tag="KRO40_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBH2092359.1"
                     /translation="MLSKAEIKYFNECASEILSSEKVQLMRTFPHHGNVSCLEHSLSV
                     AYYSYLLCKKLHLSVDIQSVIRGALLHDFFLYDWHYKGDRKGLHGFTHPREALKNATL
                     FFQINEKETDIILKHMWPLTVKPPRYKEAFIVCLLDKFCCLVETLKIHSLLSPYHV"
     gene            1750..2217
                     /locus_tag="KRO40_001539"
     CDS             1750..2217
                     /locus_tag="KRO40_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH2092360.1"
                     /translation="MFKEMRLKKREMTKEDTVEVLKNGEFGTFSTISENGYPYGVAVN
                     YVYFNDSIYFHCARNGHKLDNISKNNKVSFLVVANESVIPDKFSTTYSSAIVFGKACT
                     VENEEKKNALVEIIKKYSKGFFEEGMKYIEKDMNLTTVVKIEIDHISGKASRL"
     gene            complement(2277..2849)
                     /locus_tag="KRO40_001540"
     CDS             complement(2277..2849)
                     /locus_tag="KRO40_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH2092361.1"
                     /translation="MKVAVIFHSVCGSTYLLAREYKEALEEMNIEVDIFRVSDEVAKT
                     LPQYYLINSKEYKDEFESINVIKSGKEILDYDAIFMGSPTYYGNVSGPMKMFMDSFSD
                     IWVGTPLSGKIFGCFATAGSQHGGGELALQAMNIFAQHMGMTLLSVPCSVRGGYPAYG
                     ILHIAGDNSDIRPNDDAKIGIRDYLKRLNI"
     gene            complement(2912..4009)
                     /locus_tag="KRO40_001541"
     CDS             complement(2912..4009)
                     /locus_tag="KRO40_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBH2092362.1"
                     /translation="MLLKSLTRKIEKKYPLNLAEDWDNVGLIVGDFDMDVKKVLVSLE
                     ANEDVIDEAISKNIDLIVTHHPFIFGKINKINSGDLKGRLIQKLIKNDISLYSMHTNF
                     DIAFDGLNDYFMEIMEFGNSKVLDITKSENLYKLAVYVPHNYSDELRKVLSNSGAGHI
                     GNYSDCTFSIEGEGQFKPLEGSNPFLGSVNDIETVNEVKIETVVPQKLLGGVISSMLD
                     AHPYEEVAYDLYKLENKGEIFGLGRISKLDKSMTLESLSRKIKEKLNMKHIRVVGNLS
                     TDITKVAVVTGAGSEFVKKAKRQGAEVLITGDVKYHEAQDALDIGMCIVDCGHFDTED
                     IFKNVMKRFLDEFSEIEVIKSNVYLNPFSTI"
     gene            complement(4023..4712)
                     /locus_tag="KRO40_001542"
     CDS             complement(4023..4712)
                     /locus_tag="KRO40_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH2092363.1"
                     /translation="MKLTDRLLKIASLVSDGKKIADIGTDHGYIPVYLLKEGKVPFAV
                     LADVNKGPLDNAHKEVIQNNLLDKVDLRLGSGIEILEIGEVEEVIIAGMGGILISELL
                     EAKKEVAHNVEKLILQPMQAQEELRYYLLNNGYEILEEVLVREDFRIYEIIVAKYTGK
                     NTIIEDEIYYEVGIKLLENKDSLFNDFIEKKIKTYSSIVNKLEGKNGEAIDKKRKESE
                     VAIKKLENLIK"
     gene            complement(4877..6043)
                     /gene="rpoD"
                     /locus_tag="KRO40_001543"
     CDS             complement(4877..6043)
                     /gene="rpoD"
                     /locus_tag="KRO40_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HBH2092364.1"
                     /translation="MENKSNKKELKKVTAKTLIEKGKKQGSLTLAEIMEAFSETELDK
                     DQVENLYETLGNLGIEITETKNYKADIDFSVADDDLSIGHLDEDAEAISHDDSSAIEI
                     ETVDLSLPKGISIDDPVRMYLKEIGKIPLLKPHEEVEFARRMHEGDEIAKQRLVEANL
                     RLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDYTKGYKFSTYATWWIRQAITRA
                     IADQARTIRIPVHMVETINKLIRVSRQLLQELGRDPKPEEIAKEMEMTEDKVREIMKI
                     AQDPVSLETPIGEEEDSHLGDFIPDDDAPAPAEAAAYSLLKEQIEDVLGSLNDREQKV
                     LKLRFGLEDGRARTLEEVGKEFDVTRERIRQIEAKALRKLRHPSRSKKLRDYLD"
     gene            complement(6061..7851)
                     /locus_tag="KRO40_001544"
     CDS             complement(6061..7851)
                     /locus_tag="KRO40_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HBH2092365.1"
                     /translation="MNDIKDIIEEIKARCDIASIISEYMNIKQSGANYKGLCPFHGEK
                     TPSFYINTSKQIYKCFGCGEGGDVINFVMKMENLDFMDAVKILANKCGIEINTNMNEE
                     TRIKIEKSKKFQDIHTEAARFYLSNLLGSKNLGYEYLRIRGLDDKIIKKFGLGFSLDS
                     WNSLMNTLISKGYKKQDLLECGLIAKNRDGTNCYDKFRNRVMFPIFDYRGNIIGFGGR
                     VLDDSLPKYLNSPDTLIFNKKQNLYGLNFARKNLESKTIVLVEGYMDLISLYQYGIKN
                     VVATLGTALTEQQGILIKRYADTAIISYDSDEAGIKATLRAIDILTKLGINVKVLDLK
                     DAKDPDEFVRKYGLSDYKKAMDVSTHYIKYKIDHLKKEFNIQKDEERVKFAKEASKII
                     KQLTSPVEIDFYTKYLSNQIDINVESIKREVYGKNYNKPYNNKNQKKIEEKVIEKVEV
                     RQDGKQLVEETLIKIMLEDKKIREIALLKVEESDFLLKESKEILNYMIKNQELDKITI
                     DKLKSLNISEEYLKELNSISLNSINLENTKEIEGIITNIRKNSLEEQINSLLREQQEL
                     ENNNDMKEVDGRVMEIALKIVEINKILKSL"
     gene            complement(8106..8891)
                     /gene="aroF"
                     /locus_tag="KRO40_001545"
     CDS             complement(8106..8891)
                     /gene="aroF"
                     /locus_tag="KRO40_001545"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBH2092366.1"
                     /translation="MKENLFNNNSKIEINTNNKKITVKKDKLIIAGPCAIESYEQLLE
                     TAKFVKSQGANILRGGAYKPRTSPNSFQGLKKEGLEILKAVKDEVGMAVITELMDVRD
                     MDELYSISDIIQIGSRNMQNFTLLSEVGKQNKPVMLKRGIASTITEWIGASEYIAIEG
                     NSNIIMCERGIRTYNDYTRNTLDLAAVPIIQKETGLPVVVDPSHATGVRYLVKPMSLA
                     SFACGADGIMVEVHPDPENALSDGAQSLCFNEFEDLMKSINNY"
     gene            complement(8872..9378)
                     /gene="folK"
                     /locus_tag="KRO40_001546"
     CDS             complement(8872..9378)
                     /gene="folK"
                     /locus_tag="KRO40_001546"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HBH2092367.1"
                     /translation="MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETK
                     PWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERELHRERIVHWGPRTIDVDVLFFN
                     DVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
                     VGYERKPI"
     gene            complement(9371..9736)
                     /gene="folB"
                     /locus_tag="KRO40_001547"
     CDS             complement(9371..9736)
                     /gene="folB"
                     /locus_tag="KRO40_001547"
                     /EC_number="4.1.2.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroneopterin aldolase"
                     /protein_id="HBH2092368.1"
                     /translation="MDKILLSNLGFYGYHGVLKEENFLGQKFFVDMELYIDSREAGLS
                     DDINKSVSYAEVYNVVKDITENKQFNLLEALAENIAEEVLNKFILINGVMVRVRKPEA
                     PVNGIYDYFGVEIRRTRDE"
     gene            complement(9747..10538)
                     /gene="folP"
                     /locus_tag="KRO40_001548"
     CDS             complement(9747..10538)
                     /gene="folP"
                     /locus_tag="KRO40_001548"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBH2092369.1"
                     /translation="MFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQG
                     ADIIDLGGESTRPGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKL
                     GVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMA
                     MSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPV
                     EPKKRLEGTIATTVLGIRDGVDIVRVHDVYENLMAARMTDAIYRK"
     gene            complement(10602..11174)
                     /gene="folE"
                     /locus_tag="KRO40_001549"
     CDS             complement(10602..11174)
                     /gene="folE"
                     /locus_tag="KRO40_001549"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HBH2092370.1"
                     /translation="MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIF
                     SGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCEHHLVPFFGKAHIAYLPKGGRLT
                     GLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
                     GSKTVTSAVRGIFEKDIASRAEAMSLITMK"
     gene            complement(11200..11901)
                     /locus_tag="KRO40_001550"
     CDS             complement(11200..11901)
                     /locus_tag="KRO40_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092371.1"
                     /translation="MIGCIYEVYNEEMTKIIENQNTLAVYLVGSSKDVDFTLYDVVIN
                     DIDVFVFVKEGEKQERILFKKKGIEFDVNYFSKDGVKKLLSNREYFFVKEMKDAKVLF
                     DRENISHIIKDISRDIYLEGPSKMSLEEKSFIKQDIGAKILNLKNKEKFDVFEYHFLT
                     NLYLKDIIIGYFNINDKWVPKDKKLLKVLKKENNELFELVSKVSENYDYQRLLDVYNY
                     IFKEIETKEVIKLIF"
     gene            complement(11935..12678)
                     /locus_tag="KRO40_001551"
     CDS             complement(11935..12678)
                     /locus_tag="KRO40_001551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class IV"
                     /protein_id="HBH2092372.1"
                     /translation="MKNNVGFDSSLSKFGIGLFETIRVKNGIAVDLDIHIERMLSSIN
                     CLDLDINYKKDFLINEIVTYIKKENVINKALRITVFDEGYNISIRDIPYNQETYEKGF
                     KLAISPIVRGNSLIHRHKTTNYFENIYTKNIANKTGYNDGIFLNSEGVILECSMSNIF
                     FIKGERVYTPSDRLPILNGIIKKRIIEICDELHIELIENEINISEISSFDFVFVTNSL
                     MGAIKVTEIDKIKFNKENVVFDKIVKLLE"
     gene            complement(12668..14017)
                     /gene="pabB"
                     /locus_tag="KRO40_001552"
     CDS             complement(12668..14017)
                     /gene="pabB"
                     /locus_tag="KRO40_001552"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HBH2092373.1"
                     /translation="MIREINTKLNSFEIFTIFRNEHDSFILDSAMDKEKLGRYSFISS
                     QPFKVLKYKDTDENPLEVLKEELHKYRVVNDTNLPFVGGAVGYLSYDLGNYIENLPRT
                     AVDDIEMPDMYFGFYNHVIVIDHLVQKTYIATPNIDIELEEKIIDDIEQRILKEEKKG
                     IDSICYEEKEVTPIRLKSNFTKEEFKNAVQSVREYIRQGDIYQANLTQRFSGETELTS
                     FELYRDLRRFSPAPFGAFLNFEDAHILSNSPERFIRCVNKRIETRPIKGTRPRGKDKE
                     EDLRLQQELRNSEKDRAELLMIVDLERNDIGRISKTGSVKVPELFVIEPYANVNHLVS
                     TVVGELKDDKDATDVIKATFPGGSITGAPKIRAMEIIDELEPTQRNVYTGSIGYIGFN
                     GDMDFNIAIRTIIKNDKKVYFQVGGGMTWDSDPDEEYQETLDKAKSIMKALRGYYEE"
     gene            complement(14019..14603)
                     /locus_tag="KRO40_001553"
     CDS             complement(14019..14603)
                     /locus_tag="KRO40_001553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HBH2092374.1"
                     /translation="MILMIDNYDSFVYNLVQYIEELGEAVVVKRNNEIKISDIEELNP
                     EVIVLSPGPCSPKEAGICIDIVEHFKGKKPILGICLGHQTIGHVFGGDIIKAQQPVHG
                     KVYSINHTNKGVFRGLKNPLNVTRYHSLIVDSNTVPKELEITAITDKGEIMGIRHKKY
                     LIEGVQFHPEAILSEYGHEMLKNFITEARERVHM"
     gene            complement(14627..15346)
                     /locus_tag="KRO40_001554"
     CDS             complement(14627..15346)
                     /locus_tag="KRO40_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2092375.1"
                     /translation="MTSWKKKTVYKCLIAVALFCGIVLISNFSKVSALMMDTNGNVLI
                     KHGSREKKLIAITFDDGPHPKETSQVLDVLKKYNVKATFFIAGKHAKWYKEPLVRASK
                     EGHEIGNHTFNHPDISNLSSSQIEEEIVKCEDILKEVTGKKPTLFRPPFGSYREKDLI
                     EIAKKHDYKVVLWTGVDVKDWKNPGANSIADKIINKVQNGDIILLHDYATNDTVEALD
                     MFIPKMIEKGFKFVTVSELIK"
     gene            complement(15374..16438)
                     /locus_tag="KRO40_001555"
     CDS             complement(15374..16438)
                     /locus_tag="KRO40_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBH2092376.1"
                     /translation="MKRLIALVLVVLIVLFYSPELLKEGYDLKEKFFQSEIWNEFLDK
                     ININDNSKKDKKEKSQNLQSNNTEGENLGESDIKNFEKISLGDNLSYVLSSIGKPGRI
                     DISEYGFDWYVYNQYGKEFAMVGLENDEVVALYSNSINSCENQDIKLNQDRQTVRTKI
                     TPLKYKRKGNTRYIINSENQYDIISKEGKYITIFYDIHEENRVCSYLIIDKSTEDEFK
                     NLYPDDSEELKKCFELEVIDLVNSVRNQRGLNSLRYSEQATLSSRKHSEDMRDNNFFD
                     HVNKKNETPFDRMKREGIVYTSAGENIAAGQINAIYAHEAWMNSEGHRKNILGNYNNI
                     GVGVIFGGSYKTYYTQNFYK"
     gene            complement(16582..17391)
                     /locus_tag="KRO40_001556"
     CDS             complement(16582..17391)
                     /locus_tag="KRO40_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092377.1"
                     /translation="MNLSKEYVNLYDNYLKYINEVNKEIRSIKNMKKRVLKRGDFAPE
                     NEVLELEGKTIRDIDDVDTKKPKNKIYKFSNGDVYVGKFLEGKMEGKGSYTFFVDEGT
                     VMEYIGEFKEDKKNGKGNFIFSNGNEYIGYFEEDMMSGIGNMLYSSKDEYIGTWKNGK
                     KDGKGIYKWSDGCIYAGEFKGGKMEGYGICYNSKGEVLYEGEWKNNLIHGKGTYIWEK
                     GKKYIGEFMHGKKHGQGTFYLNNELVYEGTWKFDKPSIFDRTLDEIFSLRL"
     gene            complement(17633..18499)
                     /locus_tag="KRO40_001557"
     CDS             complement(17633..18499)
                     /locus_tag="KRO40_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2092378.1"
                     /translation="MSEVKNTLQKHPVLRYSTMLFGMLMTSIGINGFLRPAHLLSGGA
                     TGIATSINYLTNINVGLLTFLINIPIFILGFIYLEKEFCISSLVNMIVFSLLLGATQE
                     ISNIIPIHDILLQSVYGGILSGLGVGVVFRTRSSQGGTDIIAAILKIKKNIEMKDTAL
                     AINGLIVLTGSFLFGLDLALYTLIGLFLNAYSMSFIKDAMNYQKSVMVMSNEVDLIAE
                     DIMKSLVRGVTFLDAEGAYTHQKKKIIYTIVSSNEIPKIKDIALKYDKKAFISVNDVT
                     EVKGRGFKAKDL"
     gene            complement(19019..19708)
                     /locus_tag="KRO40_001558"
     CDS             complement(19019..19708)
                     /locus_tag="KRO40_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LrgB family protein"
                     /protein_id="HBH2092379.1"
                     /translation="MYNVLQTPVFGIIVTIVFFNLGRYIQRKTSNPICNPLLIAIVGI
                     ILFLSISKIPYENYKIGADSLNFFLGPVTVVLAVPLYKQFELFKKHMFEIIVGIGCGI
                     VISFVSVLIIGKIANSDVSIINSLIPKSITTPMGISLANSLNGVESITVVAIIFTGIF
                     GGMVASTVFKLGNINHPVAKGIALGTSAHALGTTKAFELGEIEGAMSGVSIGVSGTIT
                     VILIPIIMNFI"
     gene            complement(19701..20072)
                     /locus_tag="KRO40_001559"
     CDS             complement(19701..20072)
                     /locus_tag="KRO40_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CidA/LrgA family protein"
                     /protein_id="HBH2092380.1"
                     /translation="MKVFNQLVIILSIWVIGEYISSFIQGIILIPGSIVGMLLLFLLL
                     QFKVLDLSSIENVSGFFLDNMAIFFIPAGVSLIKSLDLIRENVLVLLLVICLSTLIVM
                     YTTGIIVEKMIKKKEEGQKNV"
     gene            complement(20254..21600)
                     /locus_tag="KRO40_001560"
     CDS             complement(20254..21600)
                     /locus_tag="KRO40_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH2092381.1"
                     /translation="MPRKILDISLIEDNKSDLTFFNIEEEDGDETLKALKQSYVTTNY
                     KEETLLNLQGALNSKSDTTSKELKLESYKRYNNALDLAYKNYITSAINMVNKALEINP
                     KDIDILNLRGLLKLLKCDFAKSFESFYTALCYENNHISRKYVNLISSEDFKTFLGRYN
                     HSIRFINEELNYESIHILENIIEEEPELIEPYVILSLLYDKLGNVKKREGYLDKLKEL
                     DKDNPVFEKNEEEKEDTSKKEEIKKVKRKKSILPYIIVGCVLIGMGIYLIQSKKRIEN
                     LNNQISSKEEKLSETDKKLGETSKKLEKTNKELNEVKNKEPEREITVADEEDLYYQAL
                     NLKKNKEYEKAIDNFKSVVSSGKTKKYISESIYQLAITNKLLGNKDEAIKYYKKYINT
                     YTKNDQYYDDSYYELGMLYYDNGDLKNAQQTFYSLRSEVPDSMYNNSKIKEILSEK"
     gene            complement(21782..22375)
                     /locus_tag="KRO40_001561"
     CDS             complement(21782..22375)
                     /locus_tag="KRO40_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fis family transcriptional regulator"
                     /protein_id="HBH2092382.1"
                     /translation="MNLNNITNYVQSICENISNVLDVDVTLVTKDLTRIAGTGIFRGK
                     IGETISEKSVYSLVLKDGKSYVINKEIEENCNKCANRENCKELADICTPVKMGEHILG
                     ILGIAAFNEEQKEKILSKDKELTAFVRSMSDLISFKLDELYKQEVKTIDDLEREAIEN
                     AIKKYGSNTEGMKKVAEALNIGIATLYRKVKKFNIKS"
     gene            complement(22440..23909)
                     /locus_tag="KRO40_001562"
     CDS             complement(22440..23909)
                     /locus_tag="KRO40_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBH2092383.1"
                     /translation="MSNVNKKLVIAIGAVALVVIIFIGIMCMQFKGEKIAKNTYVNGV
                     NIGKLTKSQAKQELAKKYKLENVDFNYNDKSWKVKSKDLNLSTDLDKTVENAYNLNRK
                     SAFFGNLSKTISANFGKKSNLVVAINYDKNKLKAEMEKIAKEIDVDVKDATLDISGEK
                     VKVIPDSDGLKMDISKSMENFDNQTKKGNYKNELVVKATPAKVKKEQLANIDTNLGTY
                     STTFKTSQINRSINIKLATDNISNVLLMPGETFSFNKHTGKRSKENGYKSAPVIMEGE
                     MEEDYGGGVCQVSSTLYNSVLYAGLEIVNVKNHTIPSSYVPKGRDATVADSGIDFLFK
                     NNLKHPVYIKNYVSGNQIVCNIYGSAEDKQNITISTKLDGVSQTTMKRVNDPTMPKGK
                     EKVDKSGRNAYSVSTYRTFNDANGKKIKTEKIANSYYPKKEGIILVGTMEPKPEEKPN
                     TDENKNNQNTNNQNPNNQQKPETPPTDNKPNETQPQPQA"
     gene            complement(24024..25415)
                     /locus_tag="KRO40_001563"
     CDS             complement(24024..25415)
                     /locus_tag="KRO40_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UbiD family decarboxylase"
                     /protein_id="HBH2092384.1"
                     /translation="MNFRDLFEKAVDFIDEKRKSIVAISLSTLGVIALIIVFFLSSNE
                     FSVGNEANELLKIIEKRQYSIAVDYYTSIEKKFSDSKMERFNKSVSKKINKLLLNSGD
                     KYLDGDISQESFIGLINTVKELNKISIDVDDLLAQADRVREMYKEENTTYDIAINYIS
                     TVSILNGMGSNLDVYKQNIETIKESRDVYDSAVKDQKAYKYYEAIEKYNKVLKEDEKY
                     YSMAQNGKEQCIEEMYDYYISRAEEANTSGDYERALQYIEYLKDDYSDDEKVQSLEKK
                     YKKNLSLYTLTSDDIINVIAKKSGKDKANLSINSLPQMIKNNKYYYAEVYEYDKLINE
                     VLVSAKTKDLYSYKDGKKDYKVDYGDGYFRILEDGSYQFGITKDKAKFVLTNTLDEKE
                     NKYKKIEILDIEKADRYVKSKKSLEELFGKYKNIYYYAVVNKGLFRGKEVYAINIYNE
                     KIYAISENGLNEY"
     gene            complement(25581..25829)
                     /locus_tag="KRO40_001564"
     CDS             complement(25581..25829)
                     /locus_tag="KRO40_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092385.1"
                     /translation="MMICFAMTFALVLINSVMGVHIGLDYYFLMGSVLTVCLTIGIVL
                     CNARKIFDSKAIHKTRTKTVSNNKKQKSHSRDIKRKIS"
     gene            26095..28224
                     /locus_tag="KRO40_001565"
     CDS             26095..28224
                     /locus_tag="KRO40_001565"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxiredoxin"
                     /protein_id="HBH2092386.1"
                     /translation="MPNLPSLGSKAPDFKANTTNGPIRLSDYKGNWIVLFSHPGDFTP
                     VCTTEFLCFAKYYDEFKKRNTELIGLSVDSNSSHLAWMYNISLLTGVEIPFPIIEDRD
                     MRIAKLYGMISKPMSDTSTVRSVFIIDNNQILRTILYYPLTTGRNIPEILRIVDALQT
                     SDRDNIVTPANWFPGMPVILPYPKNYKELKNRVNSCNKKYSCMDWYLCFVPDNYNDEE
                     VSKKIDNTCSWKKEHTKNIENECNCEHEHHDYLNKALDCKQEHKTDIKDDCNHEKKHT
                     KNTNKVHNSKQDKFKDKSCDEMNFNYDKDESCDKINSSYNKEDSSYEDFYKHNYKNYD
                     YTSEKNTKKIAMKTLKDSKKLVRPQITDPYNPIVENANCPDINPIVAEYVLGNPTNVD
                     AQLLDAVIFAFAEIDQSGNLFIPYPRFLNQLLALKGEKPSLKVIVAIGGWGAEGFSDA
                     ALTPTSRYNFARQVNQMINEYALDGIDIDWEYPGSSASGITSRPQDRENFTLLLTAIR
                     DVIGDDKWLSVAGTGDRGYINSSAEIDKIAPIIDYFNLMSYDFTAGETGPNGRKHQAN
                     LFDSDLSLPGYSVDAMVRNLENAGMPSEKILLGIPFYGRLGATITRTYDELRRDYINK
                     NGYEYRFDNTAQVPYLVKDGDFAMSYDDALSIFLKTQYVLRNCLGGVFSWTSTYDQAN
                     ILARTMSIGINDPEVLKEELEGIYGQF"
     gene            complement(28481..29080)
                     /locus_tag="KRO40_001566"
     CDS             complement(28481..29080)
                     /locus_tag="KRO40_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease H family protein"
                     /protein_id="HBH2092387.1"
                     /translation="MAKQKFYAVKKGKNIGVYNTWDECKKQVNGFSGAEYKSFSTFQE
                     AKEYIDGSEKLSFQEDKEFIEAYVDGSYEHSVKMYGSGVVILKNNEVIKTYSEKGKEK
                     TLVSMRNVAGEIEASKIAMQYCIDNNVQNLILYFDYEGIEKWCTGVWKTNKEGTIAYK
                     NFYDSIKNKLNVKFTKVKAHSGNKYNEEADKLAKKAIGV"
     gene            complement(29098..32217)
                     /locus_tag="KRO40_001567"
     CDS             complement(29098..32217)
                     /locus_tag="KRO40_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBH2092388.1"
                     /translation="MDNIISVLNDVVFLDIEVSGLDCLNSEILEVGAVKVKDWKIYTY
                     ESLIKNKFEVPVEVFSVCKNLDKNDLEIANEIELVEDRLVNFVEDSFIICHDLSLKKK
                     FLEYHMPKLKNKFIDLIELAVILEPYHKDYSLEYLKNTLTNCNSKVENRALSDAIDII
                     NIVNCLLVKFNNYEKTTLEPLSFKINSYLKKFNLPTWEWSKFLEEANYDLSNNINIKK
                     EYNIFDSKEEKKKERETLKILNEEEKNYEELLKYKTIWENKEGFTYEYRPGQYELTKT
                     IRELFRNSEDEEKIACIEAPTGIGKSVGYLLPAILEARINKKRLLISTDTKELQIQLI
                     NKDIPNVLDSLGLNGKVSYGYIKGKNNYICIDRLEAYIDDYESQNPTKGEILSLIFLK
                     RLVEGGKYGDIEEINYLVFDNFKEISTHLRNVSCDPNMCRPKKCKKDCLYKNRIEELK
                     EEHITVVNHSLLAKWPYKDEKPLENIIVDEAHNLTEKGYDFFSSIINSKSLRYLLQEI
                     YPYEFIQNSSFIYKKYSRNMRKIKAFDKFYNVLKIGREDKQKIARSINLIIEEIDSIL
                     KFGNCNEYNNVSNYNLRWELNLQIDEIVGKLKKDGIDTEISYRAYSEKIKLSCEKIIK
                     NLVSIIIIIYRNIDDDSIDKEADIYKFGKAKTRDLEDIKIIFEIFLEYDEKDDYARIV
                     EIDKNYNDFEFRVVPLKIADLFEENILSQLEKGIFLSATLSLSESMSYFKNTLGIDRV
                     KNVEKIIEPIFDYKNRVSVVGFSDICEYRNSEFPNEMSKIISNISKITEGHTLALFNS
                     KDRQEKTYEILKKYLHSFNLEIYADKKGIRHLNDLNRKCVVLGSKGCFEGVDIPGDGL
                     VCVTLDKLPNLNPKDPLYFTIMKKYGIDYYTINYPQMTIKVKQAMGRILRSKYDYGCF
                     VIFDVGTNISVLKRLEKDLHDCKISKVNSNEFYTYIRRHLNKYRSLILKSVIFDTIKA
                     LNVDAKMDNNDVDKDIIKKDINENIRQRAVKGEVYHIDIIKKDMKVKYFDRNYLINLD
                     IFMREEDKN"
     gene            32438..33262
                     /gene="pdaA"
                     /locus_tag="KRO40_001568"
     CDS             32438..33262
                     /gene="pdaA"
                     /locus_tag="KRO40_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBH2092389.1"
                     /translation="MKKDSLKKYIMIGAFALILFGIASINFKSLDKTKTQISSPTLDT
                     HEYDWYFNPREDGKQPSPIKEADFFKKYGAYYVGNPNEKVIYLSFDAGYESGNTPKLL
                     DTLKKHNAKAQFFVVESYIKSNPELIKRMEKEGHLVCNHSKSHPSMAGITDFEKFKEE
                     ITSVEKAYKDVTGKEMPKYFRPPMGKFSEQSLKYTQDLGYKSIFWSFAYVDWYEKKQP
                     THEFAKNKIYSRTHPGAIVLLHPNSSTNTEILDEVLTHWEKEGYKLKTLDYLNNKK"
     gene            complement(33359..34144)
                     /locus_tag="KRO40_001569"
     CDS             complement(33359..34144)
                     /locus_tag="KRO40_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2092390.1"
                     /translation="MIVKIDNTLEKEFWQYVSHEESLNLFIIGYVENYGFSSQYQDIW
                     SQVEDGNITSIILKNKSTLIIYSFKNNFNIGEMKNHIKDLDVESISGKKCVIDRLISK
                     YKDFYEKLDNKFCVLKEIKEIDFSNMKEYKIENAQEKDIDEIGKLLNRSDYKVSKNYI
                     EERKVHLKEGNVRAYFIRNDDTMISTVSTGMETSFLAMVVSVSTDKRYRGKGLASYMV
                     YNLSKELLLEGKVPCLFYNNDVAGKIYHNIGYKEINEWTILFK"
     gene            34609..34974
                     /locus_tag="KRO40_001570"
     CDS             34609..34974
                     /locus_tag="KRO40_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092391.1"
                     /translation="MKIRAEYTCLLEIVHDIIKGKWKTILIFELRQSNKTFSELQHNI
                     YGINQKMLIQQLKELRDFGIIDKISSAGYPLHVEYFLTNRGKKMLKAVEIMQEIGIEY
                     MLEHGQQEILDNKGICYNK"
     gene            35052..35606
                     /locus_tag="KRO40_001571"
     CDS             35052..35606
                     /locus_tag="KRO40_001571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBH2092392.1"
                     /translation="MSIALILIDIQNDYFKNGKCELFQSEETAENAKKILLFFRKNNL
                     PVIHIQHISTDKTASFFLPNTHGSEINKIVFPLDNEEIITKHTPDSFFETDLQSILEK
                     KNITNLVICGMMSHMCIDTSVRTAKKLRYDITLISDACTTKNLSWNNIEINANTVHQV
                     FMASLQNSFADVKNTDKFLSNYHK"
BASE COUNT        11489 a         6135 c         3640 g        14452 t
ORIGIN      
        1 cttaaatcag aaatttattc taaattaggt catatagata tagattcaaa attaatagta
       61 gatatggatt ttataaataa gaaaaataaa ataataaaaa aatttaaaat aatctattta
      121 ataccgatac tatttacttt gggaatgagt atttttatag catttaatta taatcaattg
      181 ccagactcaa ttgccactca ttggaacata aatgggtctc ctgatgtttt tatagataaa
      241 tcatttctta atgtatttaa attaatcggt actgactttt gtttaatggt tttattatat
      301 ataacttcca ttggatccat aaagtcaagg attaagatag atacaaatag aattgaagaa
      361 agtagagttg aaaacattaa atatttaaat aaaattggtt atttgttttt aatattgatg
      421 attataatga caacacagtt ttttactact cttttatcaa taaaaacaaa actatcaact
      481 gctatgaata ttacaacgct tttagttata atttatttaa tagcaacata tattaattcc
      541 ccaaatttaa aattcaactc atcttattct ccagaagaag atgagaagta ttggatagca
      601 ggcatcatgt ataataatcc aaatgaccca tcattaatgg ttaataaaag gtttggtatt
      661 ggatggacta taaattttgg caatcctctt ggaaaaatac tatatattgc tatagcttta
      721 cttttaattt tttcattgtt tagcctaata aaatctctct tactttaaaa taccataaaa
      781 ggtatcttac ttgtattatt gggtattata ttttgtagga taagaaatat ttcatattat
      841 cgttgaagta tagtatttat atattactaa gaatggagat tttcataatg ttgtcaaaag
      901 ctgaaatcaa atattttaat gaatgtgctt ctgagatact ttcttctgaa aaagttcaac
      961 ttatgagaac atttcctcat catggcaatg tttcatgtct tgaacatagt ttgtcagtag
     1021 catattatag ttatctatta tgtaaaaaat tgcacttaag tgttgatatt caaagtgtta
     1081 ttagaggagc tttactacac gacttttttc tttatgattg gcattacaaa ggtgatagaa
     1141 aaggattaca tggatttact caccctagag aagcattaaa aaatgcaact ttattttttc
     1201 aaataaatga aaaagaaacg gacataattt taaaacacat gtggccactt actgttaagc
     1261 cacctagata caaagaagca tttattgtat gtttgttgga taaattttgc tgtttagttg
     1321 agactttaaa gatacattct ttattatctc cttaccatgt ataggacaat tcccacaaca
     1381 cttttataac ttaattttga agaggtatta agtattatat tcaacttgat acctctttac
     1441 tatttattat tttatataat aatattttct ttataatata gttataaata acaacttcta
     1501 ccctcgataa cttccccttc ttatagacat gcttactatc ttaaataaca agaaaccagc
     1561 tattaaattt attagtattg tttatactac tctaacaata atatcataaa taaacctcca
     1621 aatagcttct ctttcactac cttttatctt aaactatatt tttttcttaa aatttgtaaa
     1681 aaacatagca taatctttat aaatgttcta aaatttaatt taagcatcaa aattagaaag
     1741 gatgatatta tgtttaaaga aatgagattg aaaaaaagag aaatgacaaa agaagatact
     1801 gttgaagtat taaaaaatgg tgaatttggt actttttcca ctatatctga aaatggttat
     1861 ccttatggag ttgctgtaaa ttatgtatac tttaatgatt ctatttactt tcattgtgca
     1921 agaaatgggc ataagttaga taatatatcg aaaaacaaca aagtttcttt tttagtagtt
     1981 gctaatgaaa gtgttattcc agataaattt agtactactt attctagtgc tatagttttt
     2041 ggaaaagctt gcactgtaga aaatgaagaa aagaaaaatg ctcttgtaga aataataaaa
     2101 aaatattcta aaggattctt tgaagaaggc atgaagtaca tagagaagga tatgaactta
     2161 acaactgttg ttaaaataga aattgaccat atttctggta aagcttcacg tttataatta
     2221 agtaaaaata cctaaaagta tatacagtcg cttttaggta tttttatatg atattcttat
     2281 atgttaagtc tttttaggta atctcttata cctatcttgg catcatcatt tggtcttata
     2341 tcagaattat ctcctgctat atgaagtatt ccatacgctg gataacctcc tcttactgaa
     2401 catggaactg acaaaagagt cattcccata tgttgggcaa atatattcat agcttgcaaa
     2461 gctaattctc ctcctccatg ttgtgaacct gctgtagcaa aacaaccaaa tattttacca
     2521 ctcaaaggag tacctaccca aatatcagaa aaactatcca taaacatctt cattggtcca
     2581 gatacatttc cataatatgt tggtgaaccc ataaatatag catcataatc taatatttct
     2641 tttccagatt taattacatt tatactttca aattcgtctt tgtattcttt ggaatttatc
     2701 aaataatatt gaggaagtgt ttttgcaact tcgtcactta ctctaaatat atctacctcg
     2761 atattcattt cttcaagcgc ttctttatat tctctagcta ataaatatgt actcccacaa
     2821 acactatgaa aaattactgc tactttcatc attatccccc taattaaact caaatttatt
     2881 ttttatatag tatttttatt atcaaacact gctaaatagt actaaatgga ttcaaatata
     2941 cattactttt tattacttca atttcactaa attcatctaa aaatctcttc ataacatttt
     3001 tgaatatatc ttctgtatca aaatgaccac aatccactat acacattcca atatcaagtg
     3061 catcttgtgc ctcatgatac tttacatcac ccgtaattag tacttctgca ccttgtctct
     3121 tagctttttt tacaaattct gaaccagctc ctgttacaac ggctactttc gttatgtctg
     3181 tactaaggtt tccaactact cttatgtgtt tcatatttaa tttctctttt attttccttg
     3241 aaagactttc taatgtcata cttttatcaa gtttacttat tctacctagt ccaaatatct
     3301 cacctttatt ttctaacttg tacaaatcat atgcaacttc ttcataagga tgtgcatcta
     3361 acatagaact tattacccca cctaaaagct tctgtggtac tacagtttca attttaactt
     3421 catttacagt ttctatatca tttacacttc caagaaacgg attagagcct tctaatggct
     3481 taaattgtcc ttcaccttct attgaaaacg tacaatcact ataattccct atatgacctg
     3541 ctcctgaatt acttaaaacc tttctaagtt catctgaata gttatgtgga acgtatactg
     3601 ctaatttata caaattttcg cttttagtta tatctaaaac ctttgaatta ccaaattcca
     3661 taatttccat aaaatagtca tttagaccat caaatgctat atcaaaattc gtatgcatag
     3721 aataaagtga tatatcattt ttaataagtt tttggataag tctgcctttt aaatctccac
     3781 tattaatttt attaattttc ccaaatataa aaggatgatg tgtcacaatt aaatctatat
     3841 ttttggatat agcttcatca ataacatctt cattagcttc taaagatacc aatacctttt
     3901 ttacatccat atcaaaatct ccaactataa gacctacatt atcccaatcc tctgctaagt
     3961 ttagaggata ctttttttca atttttctag ttagactctt taatagcata tatacctcct
     4021 atttatttta ttaaattttc aagttttttt attgcaactt cgctttcctt tctcttctta
     4081 tctatagctt ccccattttt cccttctaat ttattaacta tagaactata tgtctttatc
     4141 tttttttcta taaaatcatt aaaaagagaa tctttgtttt ctaaaagctt tattccaacc
     4201 tcataatata tctcatcttc tattatagta tttttacctg tatatttggc aacaattatc
     4261 tcatatattc taaaatcttc tctcactaaa acttcttcta aaatttcata tccgttgttt
     4321 aaaaggtaat atctaagttc ttcttgtgct tgcattggct gtaatattaa tttttctaca
     4381 ttatgtgcta cttctttttt agcctcgaga agctcactta tcaagattcc acccatacca
     4441 gcaattatca cttcttctac ttcccctatt tcaagtatct ctataccaga acccaatcgt
     4501 aaatcaactt tatctaaaag attgttctgt atgacttctt tatgtgcatt gtcaagaggt
     4561 cctttattaa catccgctag cactgcaaat ggtacttttc cctcttttaa caaatatact
     4621 ggtatgtatc cgtggtccgt ccctatatca gctatttttt taccatctga cactaatgat
     4681 gctattttca ataatctatc tgttaatttc aaatataatt ctcctttcaa ttccctttat
     4741 ttataggatt taatccaagt tatagatatt agactgaaat aactacaaaa ataaaattaa
     4801 atctttacta caaaatagcc atgagatatc acttatctca tggcatttat cacaaaaaca
     4861 tcaatgatgt atctttttag tctaaataat ctctaagttt ttttgatcta cttggatgtc
     4921 ttagttttct tagtgctttt gcttctatct gtcttattct ctctctagtt acatcaaact
     4981 cttttccaac ttcctcaaga gttctggctc taccatcctc aagaccaaat ctaagcttta
     5041 atactttttg ttctctatca tttaatgaac caagtacatc ttctatttgt tcttttaata
     5101 aagaatatgc tgctgcctct gctggggctg gagcatcatc atctggaata aagtcaccta
     5161 aatggctatc ttcttcttct cctattggtg tttctaaaga cacagggtct tgagctattt
     5221 tcattatttc tcttacttta tcttctgtca tttccatttc ttttgcaatt tcttctggtt
     5281 ttggatctct tccaagttct tgaagtagtt gtcttgatac tcttattagc ttatttatag
     5341 tctctaccat atgaactggt attcttatag ttctagcttg gtctgcaata gcacgtgtta
     5401 tagcttgtct tatccaccat gttgcataag tactaaactt atatcctttt gtatagtcaa
     5461 atttttcgac tgcttttata agacctaaat ttccctcttg tattaaatcc aagaaaagca
     5521 tacctcttcc tacatatctt tttgctatac ttacaactag tcttaagttt gcttcaacta
     5581 acctttgttt tgctatctca tcaccttcgt gcatccttct agcaaattct acttcttcat
     5641 gtggtttaag tagaggaatt tttcctattt cttttaagta cattcttaca gggtcatcta
     5701 tacttatccc ttttggtaaa gataaatcca cagtttctat ttctattgca gaagagtcat
     5761 catgtgaaat tgcctctgca tcttcatcta agtggcctat acttaaatcg tcatcagcaa
     5821 ccgaaaaatc tatatcagct ttatagtttt ttgtttctgt tatttctatt cccaaatttc
     5881 ctaaagtctc ataaagattt tctacttgat ccttatcaag ttcagtctcc gaaaaagctt
     5941 ccattatctc tgcaagtgtc agagaacctt gcttttttcc tttttctatt aatgtcttag
     6001 cagtaacctt ttttaactct tttttattcg atttattttc cacactcaaa cctcctttct
     6061 ctacaagctc tttaaaattt tatttatctc aactattttt aaagcaattt ccataactct
     6121 accatctacc tctttcatat cattattatt ttctaattct tgttgttctc tcaacaagct
     6181 attaatttgc tcttctaatg agttttttct gatatttgtt attattcctt ctatttcttt
     6241 tgtgttctct aagtttatac tattcaaaga aattgaattt aattctttta agtattcttc
     6301 ggatatgttt aaacttttca atttgtcaat agttattttg tccaattctt gatttttaat
     6361 catgtaattt aaaatttctt tactttcttt caataaaaaa tcactttctt ctactttaag
     6421 taacgctatt tctctaattt ttttgtcttc taacattatt tttattagag tttcttcaac
     6481 taattgtttt ccgtcttgtc tgacttcgac tttttcaatt actttttctt ctattttctt
     6541 ttgatttttg ttattatatg gcttattgta atttttacca taaacttctc tctttataga
     6601 ctcgacatta atatctattt gattgcttaa atactttgta taaaaatcaa tttcaacagg
     6661 acttgtcaat tgttttataa ttttagaagc ttcttttgcg aacttcactc gttcttcatc
     6721 tttttgaatg ttaaattctt ttttaagatg atctatttta tattttatgt agtgagtaga
     6781 aacatccata gcttttttat aatcactaag tccgtatttt cttacaaatt catctgggtc
     6841 tttagcatct tttaagtcta acacttttac attgatacct aatttagtaa gtatatctat
     6901 agctcttaaa gtcgctttta ttcctgcttc atcagaatca taagatataa tagcagtgtc
     6961 cgcatatctc tttattaaaa tgccttgttg ttcagtcaag gctgttccaa gggttgctac
     7021 tacatttttt ataccatact gataaagcga aattaaatcc atatatcctt caactaagac
     7081 tatagtttta ctttctaaat tttttctagc aaaatttaat ccgtataagt tctgtttttt
     7141 attaaaaatt aacgtgtctg gagaatttaa gtattttggc aaagaatcgt ctaatactct
     7201 tcccccaaat cctattatat ttcctctata atcgaatata ggaaacataa ctctatttct
     7261 aaatttatca tagcaattag ttccatctct attttttgca attagaccgc actccaataa
     7321 gtcttgtttt ttatatcctt tactgattag agtattcata agtgaattcc atgaatccaa
     7381 agaaaatcct aaaccaaatt tcttaataat tttatcatct agtcctctta ttcttaaata
     7441 ttcataccca agatttttgc ttcccaataa gtttgaaaga taaaatctag ctgcttccgt
     7501 atgaatatct tgaaatttct tagatttttc tattttaatc ctagtttctt cattcatgtt
     7561 agtgttaatt tctataccgc atttatttgc taaaattttt acagcatcca taaaatccaa
     7621 attttccatt ttcatgacaa aatttattac gtctccacct tcaccacaac caaaacactt
     7681 ataaatctgt tttgacgtat ttatataaaa agaaggtgtc ttttcgccat gaaatggaca
     7741 taatcctttg taattagctc cagattgttt tatattcata tattcagata ttatacttgc
     7801 tatatcgcat ctagctttta tttcttcaat aatgtctttt atatcattca tattatcacc
     7861 ttctggtgta attttttgtg ttaacatttc tattctacac tatattctaa atttgtcaat
     7921 cactcaatat acacaattcg acttttttta ttgatatcct tcttattaat caaaaaattt
     7981 ttatttttta tattaattct atcaatatta aatctttatt tatattaaat aatctaacta
     8041 tcaaattata acttataaat ttaccttagc aacgattacg aataaaaaag aggctcttgc
     8101 ctcttttaat aattattaat tgatttcatt aaatcttcaa attcattaaa gcaaagagat
     8161 tgagcaccat ctgacaaagc attttctggg tcaggatgta cttctaccat tattccatct
     8221 gctccacatg caaaagatgc cagtgacata ggttttacca aatatctaac tccagtggca
     8281 tggcttgggt ctaccacaac aggaagacct gtttcctttt gaataatggg tactgcagct
     8341 aaatctaatg tatttctagt ataatcatta tacgttctta tacctctctc acacattata
     8401 atattactat ttccttctat tgctatatat tcagaagcac ctatccattc agtaattgtg
     8461 gaagctattc ctctttttaa cataacaggt ttattttgtt ttcccacttc acttaaaaga
     8521 gtaaagtttt gcatatttct tgacccaatt tgaattatat cacttatact atacagttcg
     8581 tccatatctc ttacatccat aagttctgta ataacagcca taccaacttc gtctttaacc
     8641 gcttttaata tttcaagacc ttcttttttt aatccttgaa atgaatttgg agatgttctt
     8701 ggcttgtatg ctccacctct taaaatattt gctccctgac tttttacaaa tttagcagtc
     8761 tccaaaagtt gctcataact ctctattgca catggtccag ctattataag tttatctttt
     8821 tttacagtta tctttttgtt atttgtattt atctctatct ttgaattatt attaaatagg
     8881 ttttctttca taacctacaa gctcctttac ttcttctctt tcttcagcag ataggaggtt
     8941 taaatgttct tttattgttt tttcatttat tataagttct tcatttaaat ccataagtgg
     9001 tatcaaaacg aaagctctat cttgaatcct tggatgaggt attgttagtc tttcatcagt
     9061 ggaaactaca tcattaaaaa atagtacgtc tacatctata gttcttggtc cccaatgaac
     9121 tattctctct ctgtgtagtt ctctctctat ttcttgacaa tattctaaca actcataagg
     9181 ttcaaactct gtttctattt ctacacacat atttagaaaa tctgcttgtt ctgtatatcc
     9241 ccatggtttt gtttcgtata agcttgattc ttttacttta tatatagaat cactattttt
     9301 caaaagttca catgctcttg ataaattatc aaatctatca cccatgttag tacctattcc
     9361 caaataagcc ttattcatct cttgttctcc ttatctcaac accaaaatag tcataaatac
     9421 catttacagg agcctcaggc tttctaactc tgaccataac tccatttata agtataaatt
     9481 tattcaagac ttcttcagca atattttccg ctaaagcctc caaaagatta aattgtttat
     9541 tttcagtaat atctttaaca acattgtaaa cctcggcata gcttacagat ttatttatat
     9601 cgtcactaag acctgcttct cttgaatcaa tataaagttc catgtcgaca aagaatttct
     9661 gacctagaaa attttcttct ttaagaacac catgatatcc atagaatcct agattactaa
     9721 gtaatatttt atccattata ttatacctac tttctatata ttgcatcagt cattctagct
     9781 gccattaaat tttcataaac atcatgtact ctaactatat ctacgccatc tcttatacca
     9841 agaacagtag tagctattgt accttctaat ctttttttag gctcaactgg aagtactttt
     9901 cctattactg attttctgga tgtcccaagc aaaataggat accctaaatc ttttaattca
     9961 tttaatcttc tcaatacttc aatattttgt tcaaaatcct tgccaaatcc tacacctggg
    10021 tcaagtacta ttttttcttt ttttacacca caactcattg ccatttctat acttacctta
    10081 aaaaagtctt ttattgactc cattatatct ttgtcatagt ttgtcccatc ttgattatgc
    10141 attatacaca cttctgcatc atattttcct attacagaag ccatattttt atcttttcta
    10201 agaccccaaa catcatttac catagtgaca cctaatttta atgcttcttc tgcaacatct
    10261 gccttataag tgtctattga tattggtata tccaattcct gtttaagttt ttttattaca
    10321 gggattactc ttcttagctc ttcgtctgag tctacatagc tatgacctgg gcgtgtagac
    10381 tctcctccta ggtctattat atctgcacct tggtcaacca tatcttttgc atgttgtatt
    10441 gctatgtcca agttattaaa atctcctcca tcagaaaaac tatctggagt tacatttaat
    10501 attcccatta tataagttct tttaccataa tcaaacacaa ttaatgacac tcccttaaat
    10561 taaattttat ctcaataaat gattatatct ataataaatt actacttcat agtaatcaaa
    10621 ctcatagcct cggctctaga cgcaatgtcc ttttcaaata ttcctctcac tgctgatgta
    10681 acagtttttg aacctggttt ttttacgcct ctcattgtca tgcacatatg ttcagcttct
    10741 actactacta agacaccata aggttgtaat tcttccatta ttatatctgc agcattttta
    10801 gtgattcttt cttgtaattg tggtcttttt gccaatgtat ctattactct agcaagttta
    10861 gaaagccctg taagtcttcc tccttttggt aaataagcaa tatgagcttt tccaaagaaa
    10921 ggaactagat gatgctcaca acatgaataa aatggaatat cttttaccaa tactaactct
    10981 tcatgttttt catctgcaaa aagaactttt aaatggtctc ttggttcttc actaagacca
    11041 gagaatatct cttcatacat cctagcaact ctatttggag tttcgattag accttctcta
    11101 tctgggtctt ccccaattgc ctctagtatt tctcttactg catgttgtat cttttcttta
    11161 tcaactttat tcatttaaac tccccccatt gatttgtgac tagaagatta gttttataac
    11221 ctcttttgtc tcaatttctt taaaaatata attataaaca tctaaaagtc tttgatagtc
    11281 ataattttca cttacttttg acactagttc aaaaagctca ttattttctt tttttaaaac
    11341 ttttagcaat tttttgtctt ttggtaccca tttatcattt atattaaagt acccaattat
    11401 tatatctttt aaatataaat tcgtcaaaaa atgatattca aaaacatcaa atttttcttt
    11461 attttttaaa ttcaatattt ttgctccaat atcttgcttt ataaaagact tttcctctaa
    11521 tgacatttta ctaggtcctt ctaagtaaat atctctactt atatctttta taatatgtga
    11581 tatattctcc ctatcaaaca gtactttagc atctttcatt tctttcacaa agaaatattc
    11641 cctatttgat aataattttt ttacaccatc ttttgaaaag taatttacat caaattctat
    11701 tccctttttt ttaaacagta ttctctcttg tttttcccct tcttttacaa aaacgaacac
    11761 atcaatatcg tttatcacta catcataaag agtaaaatct acatctttac tagaacccac
    11821 taaatataca gccaaagtgt tttggttttc tattatttta gtcatctctt cattgtatac
    11881 ttcataaata caacctatca tcttttgtct ccaacaaatt gttaatattt taatttattc
    11941 taataacttc actattttat caaaaacaac attttcttta ttaaatttta ttttgtcaat
    12001 ttctgtaacc tttatagcgc ccataagact atttgtgaca aaaacaaaat caaaactact
    12061 aatttctgat atattaattt cattttctat caactctata tgtaattcgt cacaaatctc
    12121 tataatcctt ttttttatta ttccatttaa tatcggtaat ctatcactag gagtgtacac
    12181 tctttctcct tttataaaga aaatattgct catagaacat tctaatatta caccttctga
    12241 atttaaaaat ataccatcat tataaccagt cttatttgcg atatttttgg tatatatgtt
    12301 ttcaaaataa ttagtagtct tatgtctatg aattaaacta ttccccctaa ctattggaga
    12361 tatagctaat ttaaacccct tctcatacgt ctcttgatta tatggaatat ccctaataga
    12421 tatattataa ccttcatcaa aaacagtaat tctaagtgct ttattaatga cattttcttt
    12481 ttttatatat gtaacaattt catttatcaa gaaatctttt ttatagttta tatctaaatc
    12541 caaacaattt attgagctta gcattctttc tatatggata tctaaatcta ctgctattcc
    12601 atttttaact ctaatagttt caaacaaacc aattccaaat ttacttaaac tactatcaaa
    12661 acctacatta ttcttcataa tatcccctca aagccttcat tatggattta gctttatcaa
    12721 gtgtttcttg atattcttca tctgggtcag aatcccaagt cattcctcct ccaacttgaa
    12781 agtagacttt tttgtcattt ttgattattg ttctaattgc tatattaaaa tccatatcac
    12841 cattaaaacc tatataacct attgaaccag tatatacatt tctttgcgtt ggctctaatt
    12901 cgtctataat ttccattgct ctaatcttag gtgctcctgt tatagacccc cctggaaaag
    12961 ttgcttttat tacatcagta gcatctttat catcttttaa ctcacctaca actgtggaaa
    13021 ctaagtgatt tacatttgca tatggttcaa ttacaaatag ctctggaact ttaacacttc
    13081 cagttttaga tattctccca atatcatttc tttctaaatc tactatcata agtagttcag
    13141 ctctatcttt ttcactattt ctaagttctt gttgaagtct taaatcttct tctttatctt
    13201 tccctcttgg acgagtacct tttattggtc tagtttctat tctcttatta acacatctta
    13261 taaatctttc tggagaattt gataatatat gtgcatcttc aaagtttaag aatgccccaa
    13321 atggtgctgg gctaaatctt cttaagtccc tatacaattc aaagcttgta agttctgttt
    13381 ctccactgaa cctttgtgtt aaattagctt gatatatatc tccttgtctt atgtactctc
    13441 taacactttg aactgcattt ttaaattctt cctttgtaaa attagattta agtcttatag
    13501 gtgttacttc tttttcttca taacatatgc tatctatacc ttttttctct tcttttaata
    13561 ttctttgttc tatatcatct attatctttt cttctaattc gatatctatg tttggagtag
    13621 ctatataagt tttttgcaca agatggtcta taactattac atgattataa aatccaaaat
    13681 acatatcagg catctcaata tcatctacag cagttctagg taaattttct atgtaattac
    13741 ctaaatcata agataaatat cccacagcac ctcctacaaa tggaagatta gtatcattta
    13801 caaccctata cttatgtagt tcttctttta aaacttctaa aggattttca tcagtatctt
    13861 tatactttaa taccttaaat ggttggctac ttataaaaga atatcttccc aatttttctt
    13921 tatccatagc actatctaat ataaaactgt catgttcatt tctaaaaata gtaaatatct
    13981 caaaagaatt taatttagta tttatctctc ttatcatatt acatatgtac cctttctcta
    14041 gcttctgtta taaaattttt aagcatttca tgaccatact ctgacaaaat agcttctgga
    14101 tgaaactgta ctccttctat taaatatttc ttatgcctaa ttcccattat ttccccttta
    14161 tcagtaattg ctgtaatttc taattctttt ggaactgtat tggagtcaac tattagtgaa
    14221 tgatacctag tgacatttaa aggattttta agtcccctaa aaactccttt attagtatgg
    14281 ttgatactat atacttttcc atgcacaggc tgttgtgctt ttataatatc tcctccaaaa
    14341 acatgtccaa tagtttggtg acctaaacaa attcctagta taggtttttt ccccttaaaa
    14401 tgctcaacaa tatctatgca aataccagct tcttttggag aacacggtcc tggagataac
    14461 acaattacct ctggatttag ttcttcaatg tcacttattt tgatttcatt atttcttttt
    14521 actacaactg cttcccctaa ttcttctata tattggacta ggttgtatac aaaagaatca
    14581 taattgtcta tcataagaat catactgtaa atctcccccc taaaaattat tttatcaact
    14641 cagaaactgt tacaaattta aaaccttttt caatcatttt tggaataaac atatctaaag
    14701 cttcaactgt atcattagtt gcataatcat gcaaaagtat tatatctcca ttttgtactt
    14761 tattaattat tttatctgca atgctattag ctcctggatt tttccaatct ttcacatcta
    14821 cacctgtcca taaaacaact ttatagtcat gcttttttgc aatttctatt aagtcttttt
    14881 ctctataact tccgaatggt ggtctaaata atgtaggttt tttcccagtt acttccttca
    14941 aaatgtcttc acacttaaca atctcctctt ctatctgact agaacttaaa ttacttatat
    15001 caggatgatt gaaagtatga tttcctatct cgtgaccttc tttacttgct cttactaatg
    15061 gttctttata ccattttgca tgttttccag ctataaaaaa agtagctttt acattgtatt
    15121 tctttaatac atctaaaact tgactagttt ctttaggatg aggaccatca tcaaaggtaa
    15181 ttgctattag ctttttttcc cttgaaccat gtttaatcaa aacatttcca ttagtatcca
    15241 tcatcaaagc agaaacttta ctaaaattag atattaacac tattccacaa aacaaggcta
    15301 ctgctattaa gcacttatat actgtctttt ttttccatga tgtcattttt taacttcctt
    15361 tcaaatattt tagttattta taaaaatttt gagtgtaata tgttttatag cttcctccaa
    15421 atattactcc aactccaata ttattatagt tccccaaaat attttttcta tgtccttcag
    15481 agttcatcca agcttcatgc gcatatattg cattaatctg tcctgctgct atgttttctc
    15541 cagctgaagt atatactata ccttctcttt tcattctgtc aaatggagtt tcattcttct
    15601 tatttacatg gtcaaaaaaa ttattatctc tcatatcttc actatgtttt cttgaactca
    15661 aagttgcctg ttcactgtat ctcaatgagt ttaaccctct ttgatttcta acactattta
    15721 caaggtctat aacttcaagt tcaaaacatt ttttaagttc ttcgctatca tctggatata
    15781 aatttttaaa ctcatcttca gtgcttttat caattattaa atatgaacaa actctatttt
    15841 cttcatgaat atcgtagaaa attgtaatat acttaccttc cttacttatt atatcatatt
    15901 gattttctga gtttattata tatctggtat ttccttttct cttatatttt aatggtgtaa
    15961 tcttagttct cactgtttgt ctatcttgat ttagttttat atcttgattt tcacatgaat
    16021 taatagaatt actataaagt gctactactt catcattttc aagtccaacc attgcaaatt
    16081 cttttccata ttgattatat acataccaat caaaaccata ttcactaata tcaattctac
    16141 caggtttgcc gatacttgat aaaacatagc ttaaattatc tcctaagctt attttttcaa
    16201 aattctttat atctgactct cctaagttct ccccttcagt attatttgat tgtaaatttt
    16261 gacttttttc ttttttatct ttcttagaat tatcatttat atttattttg tctaaaaatt
    16321 cattccatat ttcactttga aaaaactttt cttttaaatc atatccttct tttaataatt
    16381 caggactata aaataaaaca ataagtacta ctaacactaa agcaattaat ctcttcaata
    16441 tatctctcct tcttaaaatc aatcaaaatt ttttaatatt gcatttatta agttaatatt
    16501 gatagtgtat actaatcaat atcattcata cctatttaca gtaagtatta gaaaaaagct
    16561 ttatctacta attagataaa gctacagtct caaggaaaat atttcatcta atgttctatc
    16621 aaatatagat ggcttatcaa atttccaagt cccttcataa accaattcat tatttagata
    16681 aaaagttcct tgcccatgtt ttttaccatg cataaattca cctatatact ttttaccttt
    16741 ttcccatata taagttccct taccatgaat caaattattc ttccattctc cttcataaag
    16801 tacttcccct ttactattat agcaaatacc gtacccttcc atctttccac ctttaaattc
    16861 acctgcatat atacatccat cactccactt ataaatacct tttccatctt tttttccgtt
    16921 tttccaagtt ccaatatatt catctttact actatataac atatttccaa taccgctcat
    16981 catatcttcc tcaaaataac ctatatattc atttccattt gaaaatataa agtttccttt
    17041 tccatttttt ttatcttctt taaattctcc tatgtactcc ataactgttc cttcatctac
    17101 aaaaaaagta tatgagcctt tcccctccat ctttccctct aagaatttcc ctacatatac
    17161 atccccattt gaaaatttat agattttatt ttttggtttt tttgtatcga catcatctat
    17221 atcgcgtatt gtttttcctt ccaattctaa tacttcattt tccggagcaa aatcgcccct
    17281 ttttaaaaca cgtttcttca tgttctttat acttctaatc tctttgttta cttcatttat
    17341 atatttcaaa taattatcat acaaattaac atattcttta gataaattca taatgccatt
    17401 cctccaacgt tattcctagg tattttacta aatctattaa atttattata tcctaatagt
    17461 ggtcatgttt tctacatatt aagtaatttt ttcaatttta attttaaaat gatatctttt
    17521 aaagtgatac acaaatcatt aataaaacct ttattttcgt atactaaatt taaataagct
    17581 gagagatata atatacaaat ttacattata aactcccagc ttgtaaaatt ttctataaat
    17641 cttttgcttt aaaccctctt ccctttactt ctgtaacatc atttacagat ataaaggcct
    17701 ttttatcata cttcaaagct atatctttta tctttggtat ctcatttgat gaaactattg
    17761 tatatataat cttctttttt tgatgagtgt atgcaccttc tgcatctaaa aaagttacac
    17821 ctctaactaa actcttcatt atatcttctg ctattaaatc gacttcattt gacattacca
    17881 taacagattt ttggtaattc attgcatctt taataaaact cattgaatac gcatttagaa
    17941 atagacctat aagagtgtat aatgctaaat ccaacccaaa taaaaaactt cctgtaagta
    18001 ctatcaagcc atttattgct aaagcagtgt ctttcatttc tatattcttc ttaattttta
    18061 gtattgcagc tattatatct gtaccacctt gagaagacct agttctaaat acaactccga
    18121 ctcctaaacc agataatata ccaccatata cactttgaag caatatatca tgtataggta
    18181 taatattact tatttcctga gttgctccta ataataatga aaatacaatc atatttacca
    18241 aacttgaaat acaaaactct ttttcaaggt atatgaaccc taagataaat attggaatat
    18301 tgattaaaaa tgttaataaa cctacattta tatttgtcaa atagtttata gatgttgcta
    18361 tacctgtagc acctccacta agcagatgtg ctggtcttaa gaacccattt attcctatag
    18421 atgtcatcaa catcccaaat agcattgttg aatatcttaa aactggatgt ttttgtaggg
    18481 tattcttaac ttcactcatt tctttctccc ttcaatcttt ctaaatcttt agaattttaa
    18541 aagcttactc ttacatatat tattcctgat gtaatagata atatttcaaa taaatttttt
    18601 ttataatttc ttgaactgtc atctattaca tcatctatta tattatcttt ttcatatatg
    18661 tctagtgcaa tcttttatat tctaatcttt aaaaacgttc aaatcatctc atttatgcct
    18721 taaatgaaac tttttctagc ataatatgat actgcttatt atttaacttg caatatagta
    18781 aatttatagt atttttttct aaatatctat tttagcagta atttatttta ttttagcaaa
    18841 ttcaagttta gtaattgtct ctttataatt aattcctaaa tgaaattttt ctttttataa
    18901 tttcagtaca tgattttttt atttcattat ttgcattttt ttcgttcagt ttttatttta
    18961 aatttttttt attttatttt gttttaagta ttcaaggtac tcatcttaat tttatttttt
    19021 atataaaatt cattataatt ggaattagta ttactgtaat tgtaccagag actccaatag
    19081 aaacaccact catagctcct tctatttctc caagttcaaa agcctttgta gttcctaaag
    19141 catgtgcaga tgttccaaga gcaattcctt tagcaactgg atgatttata ttccccagtt
    19201 tgaatactgt agaagcaacc ataccaccaa aaatacctgt aaaaattatg gctacaactg
    19261 ttattgattc tacaccattt aaagaatttg ctaaagatat tcccattggt gttgttatag
    19321 attttggaat tagtgaattt attatactta catctgaatt agctattttg ccaattatca
    19381 atacagatac aaaagaaatc actataccac aacctattcc tacaataatc tcaaacatat
    19441 gctttttaaa taattcaaat tgtttataaa gtggaactgc aagtactact gtgacaggac
    19501 ctaaaaagaa atttagacta tcagctccta tcttgtaatt ctcataaggg attttagata
    19561 tgcttaaaaa caatattatt cctacgattg caattaataa agggttacat ataggattac
    19621 ttgtttttcg ttgaatgtat cttcctaaat tgaaaaaaac tattgttact attataccaa
    19681 atactggtgt ctgtaataca ttatacattt ttttgtcctt cttccttctt ttttatcatt
    19741 ttctccacaa taattccagt agtatacatt actattagtg tacttaaaca tatgactaat
    19801 aaaagcacta atacattttc ccttattagg tctaatgact ttataagtga tacacctgct
    19861 ggaataaaaa atatagccat attatcgagg aaaaatccac ttacattttc tatactactc
    19921 aagtctaaaa ctttaaattg tagtagtaga aataataata gcataccaac tatactccca
    19981 ggaataagta taattccttg tataaaggaa cttatatact ctcctattac ccagatagat
    20041 aaaattatta ccaattgatt gaaaactttc attttccacc tccaaaaatt aaagagattg
    20101 cttcaaatca tatatttgta gttttatcaa caagcaaata tctttcttta aaatagaaag
    20161 ttataatttg acacaatctc tttttaaatt tatttttatt ttaatttaat aaaatacata
    20221 cttggttgtt tcaaaaaact taactatata aacctatttt tcacttaaaa tttcttttat
    20281 ttttgaattg ttatacatac tgtctggaac ttcacttctc aaactataaa aagtctgttg
    20341 tgcatttttt aaatcgccat tatcataata aagcataccc aactcgtaat atgaatcatc
    20401 ataatactgg tcatttttag tataagtatt tatatatttt ttgtaatatt ttatagcttc
    20461 atccttattt cctaataatt tatttgttat tgctaattga tatattgact cagaaatata
    20521 ttttttagtt ttaccagaag aaactacact tttaaaatta tctatggctt tttcatattc
    20581 tttgtttttc tttaaattta gagcttgata atataaatct tcctcatcag ctacagttat
    20641 ctctctttct ggttctttat ttttaacctc atttaattcc ttattcgttt tttctaattt
    20701 tttactcgtt tctcctaact ttttatcagt ttcacttaac ttttcctctt tactacttat
    20761 ttggttattc aagttttcta ttctcttttt gctttgaatc aaatatatcc ccatacctat
    20821 taaaacacag ccaactataa tatatggcaa aatacttttc tttcttttta ctttttttat
    20881 ttcttccttt ttacttgtat cttctttttc ttcttcattt ttttcaaata caggattatc
    20941 tttatctagc tctttaagtt tgtctaaata tccttctctc ttttttacat tacctagttt
    21001 atcatataac aaagataaaa ttacatatgg ctctattagt tcaggttctt cttcaattat
    21061 gttctctaaa atatgtattg actcataatt taattcttca tttataaatc ttatagaatg
    21121 attgtatctt cctaaaaaag ttttaaaatc ttcagatgaa attagattta catattttct
    21181 agatatatga ttattttcat aacataaagc agtataaaaa ctctcaaatg atttagcaaa
    21241 atcacatttt aataatttta aaagacctct aagatttagt atatcaatgt ctttaggatt
    21301 tatctccaga gctttattaa ccatattaat ggcactagtt atataatttt tatatgctaa
    21361 atccaatgca ttgttatatc ttttatatga ttctaatttt aactccttag acgttgtatc
    21421 tgactttgaa tttaaagctc cttgcaagtt taatagagtt tcttctttat aatttgtagt
    21481 cacataactc tgttttaatg cttttaatgt ttcatcaccg tcttcttctt ctatattaaa
    21541 aaaagtcaaa tcacttttat tatcttctat caaagatata tctaaaattt ttctaggcat
    21601 gctttctatg tcttgtttta tatctttaac taaaataata ctcacctcca ctctaaaata
    21661 tatatttaag ataacatatt taatatgtca agtcaaaact atacatattt ttccaccatt
    21721 ctcataataa aaaaggtaat cctcttcttt tcataaaaag gttacctctt tttcaatact
    21781 attaactttt aatgttgaat ttttttactt ttctatagag tgtagctata cctatattta
    21841 atgcctcagc tacttttttc ataccttctg tattacttcc atatttcttt atggcatttt
    21901 ctatagcttc cctctcaagg tcatctatag tcttaacttc ttgtttataa agttcatcta
    21961 gtttaaaaga tattaaatca gacatactcc ttacaaaagc agttaactcc ttatcttttg
    22021 aaagtatctt ttctttttgt tcttcattaa acgcagctat acccaagatt ccaagtatat
    22081 gctctcccat tttaacggga gtacatatat cagctaactc tttacaattt tctctatttg
    22141 cacatttatt acagttctct tctatttctt tatttataac ataggatttc ccatctttta
    22201 aaacaagaga gtacactgac ttctctgata ttgtctctcc tattttacct ctgaatattc
    22261 ctgtacctgc tatcctagtt aaatcttttg taactaaagt aacatctaca tccaagacat
    22321 tagaaatatt ctcgcaaata ctttgaacgt aattcgttat attatttaaa ttcaaagtaa
    22381 tccctcctat ttagatttat attttttatt actctacata aatcctattc ttgagaactt
    22441 taagcttgcg gttgtggttg tgtctcatta ggcttattat cagttggtgg tgtttctggt
    22501 ttttgttgat tatttgggtt ttgattgttt gtattttgat tattcttatt ttcgtctgta
    22561 tttggttttt cctctggttt tggttccata gtcccaacta atataatacc ttccttctta
    22621 ggataatatg aattagctat tttttcagtt ttaatttttt taccatttgc atcattaaat
    22681 gttctatatg ttgatacaga atatgcattt cttccacttt tgtctacttt ttctttacct
    22741 ttaggcattg tagggtcatt aactcttttc attgtagttt gtgaaacgcc atctaatttt
    22801 gttgatattg ttatattttg tttatcttct gcacttccat atatattgca aacaatttga
    22861 tttcctgaaa cgtaattttt tatgtaaact ggatgcttta gattattttt aaataagaaa
    22921 tctattccac tatctgcaac agttgcatct cttccttttg gaacataact tgatggtata
    22981 gtatgatttt ttacattaac aatttctaaa cctgcgtata gcacagaatt gtataacgta
    23041 gatgaaactt gacaaactcc tccaccataa tcttcttcca tctcaccttc cattattaca
    23101 ggtgcacttt tatatccatt ttccttactt cttttccctg tatgtttatt aaatgagaaa
    23161 gtttctcctg gcataagtaa tacattactt atattatctg ttgctaattt tatgtttata
    23221 cttctattta tttgagaagt tttaaatgtt gttgaatacg tacctaaatt tgtatctata
    23281 ttagcaagtt gctctttttt tacttttgct ggagtagctt ttactactaa ctcattttta
    23341 tagttacctt ttttagtttg attatcaaaa ttctccatac tcttagaaat atccatttta
    23401 agaccatcag aatctggtat aaccttgact ttttcaccac ttatatcaag tgtagcatct
    23461 tttacatcta catctatttc tttagctatc ttttccattt ctgcttttaa tttattttta
    23521 tcataattta tcgcaactac taagttgctt tttttgccaa aatttgctga aatagttttt
    23581 gatagattgc caaagaaagc actctttcta tttaaattat atgcgttttc tactgtttta
    23641 tccaggtcag tagataaatt taaatctttg ctctttactt tccagctttt atcattgtaa
    23701 ttaaaatcaa cattctctaa tttgtatttt ttagctaatt cctgttttgc ttgtgattta
    23761 gttaattttc caatatttac tccattaaca tatgtgtttt ttgctatttt ctccccttta
    23821 aattgcatgc acattatgcc tataaaaatt attactacta atgctacagc tccaatagct
    23881 ataactagct ttttgttcac attactcatc ccatacttct ccttacaata aaattattta
    23941 tatatcccta ttattatatt actacataat gcgccttaaa accccaaaaa ctttttaatt
    24001 atatattaat ttaatattat taattaatat tcatttagtc cattttctga tatggcatat
    24061 attttttcat tgtaaatatt aatagcataa acttctttgc ctctaaataa gcctttattt
    24121 actacagcat aataataaat atttttatat tttccaaaca attcttctaa actcttttta
    24181 ctttttacat atctatctgc tttctctata tctaatatct caatcttttt atacttattt
    24241 tctttttcat caagagtatt agttaacaca aacttagctt tatcttttgt aataccaaat
    24301 tgataacttc catcttctaa tattctaaag tatccatcac cataatctac tttgtaatct
    24361 tttttaccat ctttatatga atataaatct ttagtttttg cacttaccaa aacttcattt
    24421 attaatttat catactcata tacttcagca taatagtatt tattattttt tatcatttgt
    24481 ggaagtgaat ttatagatag atttgccttg tctttgccac tttttttagc tattacattt
    24541 ataatgtcat cagatgttaa agtatacaat gataaattct ttttatattt tttttctaaa
    24601 ctctgtacct tttcatcatc tgaataatcg tcttttaaat actcaatata ttgtaatgct
    24661 ctttcataat ctccagaagt atttgcctct tcagctctac ttatatagta atcatacatt
    24721 tcttcaatac attgttcttt cccattttga gccatactgt aatacttttc atcttctttt
    24781 aatactttat tatacttttc aatagcttca taatacttat atgctttttg gtcttttact
    24841 gctgagtcat aaacatctct agactctttg attgtttcta tattctgttt gtatacatct
    24901 aggttactac ccataccatt taatattgaa acagtactta tgtagttaat ggcaatatca
    24961 taagtagtat tttcttcttt atacatttct ctaactctat cagcttgagc taataagtca
    25021 tccacatcta tacttatttt gtttaattct ttcacggtat ttattaatcc aataaaactt
    25081 tcttgactta tgtctccatc taaatattta tcaccactat ttaatagcaa tttatttatt
    25141 tttttagaaa cagacttatt aaacctttcc atttttgaat cagaaaactt tttttctata
    25201 cttgtgtagt aatcaacagc tatagaatac tgtcttttct ctataatctt taacaactca
    25261 ttagcttcat ttcctacact aaactcgtta ctacttaaga aaaatactat tatcaaagca
    25321 attacaccta atgttgataa tgaaatcgca actatagatt tccttttttc atcaataaaa
    25381 tctacagcct tctcaaataa atctctaaaa ttcattatag ttccctctcc atttaataat
    25441 ctttatattt tatggtaaac taaatttctt attggttatt atatcataat tcttgaaaaa
    25501 aaataaaaac acaagttaaa tcgtgttttt attttaccta tcaatcatta ttttatacat
    25561 aaatatttcc tttacataaa ttatgatatc tttcttttta tatccctaga atgactcttt
    25621 tgttttttat tattactgac agttttcgtt cttgtcttgt gtatagcttt gctatcaaat
    25681 atttttctag cattgcataa aacaattcca attgttaaac aaactgtaag cacacttccc
    25741 atcaaaaagt aataatccaa tcctatatgt actcccataa ctgaatttat taacactaat
    25801 gcaaaagtca ttgcaaaaca tatcatcatg gagataacta aaattcttag aatttttttc
    25861 aatccactca cctcgtataa tcactaaaat tgacactacc ccttatccat tactatacca
    25921 aattagtaaa aaaatagcaa ttactattgt catttatatt aggaaaatat taaatctttt
    25981 taataaatat ctttttttga cataaggatt acttaacttt taataaaata gtaacactaa
    26041 tatgtattaa ttaatagaat aaaataaatg ataatttatt gaggggtgat ttacatgcca
    26101 aatttgccaa gtttagggtc aaaggctcct gattttaaag ccaatacaac aaatggtcct
    26161 attagactct ctgactataa gggtaattgg attgttttat tttcacatcc tggtgatttt
    26221 acaccagttt gtactacaga atttttatgt tttgctaaat attatgacga atttaaaaaa
    26281 agaaatacag aactaattgg tctaagtgtt gatagtaaca gttcacattt agcttggatg
    26341 tataatattt ctttacttac aggtgtagaa attccatttc ctattataga agatagagat
    26401 atgagaattg ccaagttata cggcatgata tcaaaaccaa tgagtgatac atcaactgtt
    26461 cgctctgtat ttattataga taataatcaa attctaagaa cgattcttta ttatccacta
    26521 actacaggaa gaaatattcc agaaatactt agaatagtag atgcacttca gactagtgat
    26581 agagataata tagttactcc tgcaaactgg tttcctggaa tgccagtgat tttaccttat
    26641 cctaaaaact ataaggaatt aaaaaataga gttaacagtt gtaataagaa atattcatgt
    26701 atggactggt acttatgttt tgtaccagat aattataatg atgaagaagt gagcaagaaa
    26761 attgataata cttgtagctg gaaaaaagaa catactaaaa acattgaaaa tgaatgtaac
    26821 tgtgaacatg aacatcatga ctacctgaac aaagctcttg actgtaaaca agaacacaag
    26881 actgatatta aagatgattg caatcatgag aaaaaacata ctaaaaatac taacaaagtt
    26941 cacaactcca aacaagataa gtttaaagat aagtcttgtg atgaaatgaa ttttaactat
    27001 gataaagatg aatcttgtga caaaataaat tctagctata acaaagaaga tagtagttat
    27061 gaagatttct ataaacataa ttataaaaac tacgattata ctagcgaaaa aaatactaaa
    27121 aaaatagcta tgaaaacttt aaaagattct aaaaaattag ttagaccaca aataacagac
    27181 ccatacaatc caatagttga aaatgcaaac tgtccagata taaatccaat tgtagcagaa
    27241 tatgttcttg gaaatccaac taatgtagat gctcaactat tagatgcagt tatatttgct
    27301 tttgctgaga tagaccagtc tggaaatttg tttattcctt atcctagatt tttaaatcaa
    27361 ttacttgctc ttaaaggtga aaaacctagc ttaaaagtaa ttgtagctat tggaggttgg
    27421 ggagctgaag gattctctga tgcagcatta acacctacat ctagatataa ttttgcaaga
    27481 caggtcaatc agatgataaa tgaatatgct ttagatggaa tagatataga ctgggaatat
    27541 cctggaagta gtgcatctgg aataacatca agacctcaag atagagaaaa ctttacactc
    27601 ttactaactg ccataagaga tgttatagga gatgataaat ggcttagtgt agctggaaca
    27661 ggagatagag gatatataaa ttcaagtgct gaaatagata aaatagctcc tataatagat
    27721 tattttaatc ttatgagtta tgattttaca gcaggtgaaa caggcccaaa tggtagaaaa
    27781 catcaagcaa atctttttga ttcagactta tctttgccag gatatagtgt tgatgcaatg
    27841 gtaagaaatc ttgagaatgc tggaatgcct tctgaaaaaa tccttcttgg tataccattt
    27901 tatggaagat taggtgctac tataacaaga acttatgatg agcttagaag ggattatata
    27961 aataaaaatg gatatgaata tagatttgat aatactgctc aagttccata tttagttaag
    28021 gatggagatt ttgcaatgtc atatgatgat gctttatcaa tattcttaaa aactcaatat
    28081 gttcttagaa attgtctagg tggtgtattc tcatggacat caacttatga ccaagcaaat
    28141 atactggcta gaaccatgtc tattggtata aatgaccctg aagtattaaa agaagaactt
    28201 gaaggtattt atgggcaatt ctaatagaat gtaggaaaat tttatagtta tataaaaagc
    28261 agattttatt atattaaata agttgtatct aattaatact attattaatt gtttataaat
    28321 tagatactta ttttttcata atacaatctg cttttttaat caaaatttat ttaattataa
    28381 gttgtttaat tacaagttgt ttaattacaa gttgtttaat tataaagtag gaatttagat
    28441 atactcttat accatgtaat tatgtataaa tattttttta ttatacacca atagcttttt
    28501 tagctaattt atctgcttcc tcattatact tatttccaga atgagcttta acctttgtaa
    28561 attttacatt aagcttattc ttaatactgt catagaaatt tttatatgct atagttcctt
    28621 ctttatttgt tttccaaact ccagtacacc acttttcaat cccttcatag tcaaagtata
    28681 aaatcaagtt ttgaacatta ttgtcaatac agtactgcat tgcaatttta gaagcctcta
    28741 tctctccagc tacatttctc atacttacta aagttttctc ttttcctttt tcactataag
    28801 tttttataac ttcattattt tttaaaatca caacacccga accatacatt tttactgaat
    28861 gttcataact tccatctaca tatgcttcta taaactcctt atcttcttga aaactcaatt
    28921 tttctgaccc atcaatatat tctttagctt cttgaaaagt agaaaaactc ttatattcag
    28981 ctcctgagaa tccatttact tgttttttgc actcatccca tgtattatat acacctatat
    29041 ttttaccttt tttcacagca taaaactttt gttttgccaa atatatcact cccactctta
    29101 atttttatct tcttctctca taaatatatc taaatttata agatagtttc tatcaaaata
    29161 ttttactttc atatcttttt ttataatatc aatatggtac acttctcctt ttacagctct
    29221 ttgtcttata ttttcattta tatctttttt tataatatcc ttatcaacat cattgttatc
    29281 cattttagca tcaacattca acgcttttat agtatcaaat ataacagatt ttagtattaa
    29341 acttctatat ttatttaaat gtcgccttat ataagtataa aactcattgc tattaacctt
    29401 tgaaatttta caatcgtgta aatctttctc taatctcttt aacacactta tattagttcc
    29461 tacatcaaaa atcacaaaac atccatagtc atatttgctt cttaaaattc tccccatagc
    29521 ttgctttacc tttatggtca tttgaggata atttatagta tagtagtcta taccatactt
    29581 cttcattata gtaaaataca aagggtcttt tggatttaga ttcggaagct tgtctaaagt
    29641 tacacaaacc aaaccatccc ctggaatgtc tacgccttca aaacatcctt ttgagccaag
    29701 tactacacat tttctattta aatcgttaag gtgtctaatc ccctttttat cagcataaat
    29761 ttctaagtta aaactatgta agtatttttt caatatttca taagtttttt cttgtctatc
    29821 tttactatta aaaagagcta atgtatgacc ttctgtaatc tttgatatat tagatataat
    29881 tttactcatc tcatttggaa attcagaatt tctgtactca caaatatcag aaaatccaac
    29941 tacagagact ctatttttat aatcaaaaat tggttctata atcttttcca cattcttaac
    30001 tctgtctatt cctaatgtat ttttaaaata agacatactt tcagataaac tcaaagttgc
    30061 tgataaaaat attccttttt ctaattgaga taaaatattt tcttcaaata aatctgctat
    30121 ttttaatggc actactcgaa attcaaagtc attataattc ttatcaattt caactatcct
    30181 tgcataatca tccttttcat catactctaa aaagatttca aatataatct ttatatcctc
    30241 taaatctctt gtctttgcct ttccaaattt atatatatct gcttctttat ctatactatc
    30301 atcatcaata ttcctataaa ttattattat tattgaaact aaatttttta ttattttctc
    30361 acaactcaac tttatctttt cactataggc tctataactt atttcagtat ctataccatc
    30421 cttttttagt tttcccacaa tttcgtctat ttgcaaattc agttcccatc ttaaattata
    30481 attacttaca ttattatatt cattacaatt accaaacttt aatattgaat ctatctcttc
    30541 aataatgaga tttatacttc tagcaatttt ttgtttatct tctcttccaa tttttaatac
    30601 attataaaat ttatcaaaag cctttatttt tctcatattt ctactatatt ttttatatat
    30661 aaagctacta ttttgaataa actcgtaagg ataaatttct tgtaataaat accttaaaga
    30721 ctttgaattt ataatgcttg aaaagaaatc atatcctttt tcagtcaaat tatgtgcttc
    30781 atctactatt atattttcta aaggtttttc atccttatat ggccatttag ctaatagtga
    30841 atgatttact actgttatat gttcttcttt taattcttct attctgtttt tatataaaca
    30901 atcttttttg cattttttag gtctgcacat atttgggtca caacttacat ttcttaagtg
    30961 agtacttatt tccttgaagt tgtcaaacac taaataattt atttcttcta tatctccata
    31021 cttgccacct tcaactaatc tcttcaaaaa tattaaagat aaaatttctc ctttagtagg
    31081 gttttgagac tcataatcat ctatatatgc ttccagtcta tctatacaaa tatagttatt
    31141 ttttcccttt atatatccgt aacttacttt tccatttaga cccaaagaat ctaacacatt
    31201 tggaatatct ttatttatta attgtatctg caattccttt gtgtcagtag aaattaataa
    31261 tcttttttta ttaattctag cctctaatat tgcaggcaat aaatatccta cacttttacc
    31321 tataccagtt ggtgcctcta tacatgcaat tttttcttca tcttcgctat ttctaaacaa
    31381 ctctcttatt gttttagtaa gctcatattg accaggtcta tattcatatg taaatccttc
    31441 tttattctcc caaatagttt tgtattttaa taattcttca taattttttt cttcttcatt
    31501 taaaattttt aaggtttctc tttccttctt cttttcttct tttgagtcaa atatattata
    31561 ttcttttttt atatttatat tatttgataa atcataattt gcctcttcta aaaatttgct
    31621 ccattcccat gttggaagat taaatttttt aagatatgaa tttattttaa aactcaatgg
    31681 ctccaaagta gttttttcat agttattaaa ttttactaaa aggcaattta caatatttat
    31741 tatatcaata gcatctgata aagctctatt ttccacttta gaattacaat ttgttaaagt
    31801 attttttaag tattctaagc tataatcttt atgatatggt tctaaaataa ctgctaattc
    31861 aattaaatca ataaatttgt tttttaactt tggcatatga tactcaagaa actttttttt
    31921 cagacttaaa tcatgacata taatgaaact atcttctaca aaatttacaa gtctatcttc
    31981 caccagttct atttcattag ctatttctaa atcattttta tctaaatttt tacatactga
    32041 gaatacttct acaggtacct caaatttgtt ttttattaat gattcatagg tatatatttt
    32101 ccagtcttta accttgacag ctccaacttc taaaatttct gaatttaaac aatctaatcc
    32161 actaacttct atatctaaaa aaacaacatc attcaataca cttattatat tatccatttt
    32221 tatatccctt caagttaaac cagcctaact tatttacaat catttctctt tatattttat
    32281 catttatata cactttattt aagataatta atatcaactt tatatcttac agtaaacttc
    32341 tttcatttat tatttgtata tgtgaatatt tttaactata aatattcaaa ctatattata
    32401 agaaatatac tttaaatttt aaataagagg tgaaattgtg aaaaaagata gcctaaaaaa
    32461 atacattatg ataggagcat ttgctctaat actttttgga attgctagta taaattttaa
    32521 atcattagat aaaacaaaaa ctcaaatttc tagtccaaca ctcgacacac atgaatatga
    32581 ttggtatttt aaccctaggg aggatggtaa acagccatca cctataaaag aagctgattt
    32641 ttttaaaaaa tacggagctt attatgtagg aaatcccaat gaaaaagtta tatatctatc
    32701 atttgatgct ggatatgaaa gtggaaacac tccaaaatta ttagatacgc ttaaaaaaca
    32761 caatgctaaa gctcaatttt tcgtagttga aagttatata aaaagcaatc cagagttaat
    32821 aaagcgtatg gaaaaagaag gacatttagt ttgtaatcat tcaaaaagcc atccatcaat
    32881 ggcaggtatt acagattttg aaaaattcaa agaagaaatt acaagtgtag aaaaagcata
    32941 caaagatgtt actggaaaag aaatgcctaa gtattttaga cctccaatgg gtaaatttag
    33001 cgaacaatct ttaaaatata cacaagattt aggatataaa tcaatatttt ggagttttgc
    33061 ttatgtagat tggtatgaaa agaaacaacc tactcatgaa tttgccaaaa acaaaattta
    33121 ttcaagaact catcctggtg caatagtttt actgcatcca aattcatcaa caaatactga
    33181 gatattagat gaggttctta cacattggga aaaagaaggt tataaactta aaacacttga
    33241 ttatttaaat aataaaaaat agtatcataa atttaaaaaa actctatcat gaattatagt
    33301 aaaaatatag ttatttataa atactttaat tctcgataga gttttttatt ttttatagct
    33361 atttaaaaag aattgtccat tcatttatct ctttgtatcc tatattatga tatattttac
    33421 ctgctacatc attattataa aaaagacatg gaacttttcc ttctaacaac aattctttac
    33481 tcaaattgta aaccatataa cttgcaagtc cttttcccct atatctttta tctgtactta
    33541 cagagaccac cattgccaaa aaactagttt ccataccagt tgacacagtg ctaatcatag
    33601 tatcatcatt tctaataaaa tatgctctta catttccctc ttttaaatga acttttcttt
    33661 cttctatgta atttttactt actttatagt ctgacctatt taaaagtttt cctatttcat
    33721 caatatcttt ttcctgagca ttttctattt tatactcctt catgttggaa aaatctattt
    33781 cttttatttc ttttaataca caaaatttat tatctagttt ttcataaaaa tctttgtatt
    33841 tacttattag tctatctatt acacattttt ttccacttat gctttctaca tctaaatctt
    33901 ttatatgatt cttcatttct cctatattaa aattattttt aaaactataa attataagtg
    33961 ttgacttatt ttttaatatt atagaggtta tatttccatc ttctacctga gaccatatat
    34021 cttgatattg agagctaaat ccataattct caacgtatcc aattatgaat aaatttaaac
    34081 tttcttcatg tgatacatat tgccaaaatt ctttttctaa agtattatct atttttacaa
    34141 tcaagcagat atcctccttc tatgttaata atgatatacc ttataattta tagtatcatt
    34201 taaaatcatt atattctacc aaatattcta aatttttaaa tatctatgca atatgttcgt
    34261 atttattttt atattctgtt actgcttcac tccaagcttc ttctactgaa atacctctct
    34321 tatttgcaat tttttgtgct aattctatta ttttcatagc ttttcttgat atattcatat
    34381 atattcctcc tctaaattat cataagttat tttaaagtta aatttctata gtcatgttat
    34441 atatttattt acttatatct tactaattat ttatgtacta aatatgaact acaatagaag
    34501 aaatttagaa cttaataaaa cataaaattt atatacagtt catatatatt tgtcatatca
    34561 caagacaagt gatataattt attatcattt tactgggggt gatatgctat gaaaataaga
    34621 gctgaatata catgtcttct tgaaattgta catgacataa tcaaaggaaa atggaaaact
    34681 atccttatat ttgaattaag acaatctaat aaaacatttt ctgaattgca acataatatt
    34741 tatggaataa atcaaaaaat gttgattcaa caattaaaag agttacgtga ttttgggatt
    34801 attgataaaa taagttctgc tggatatcca ttacatgttg aatattttct tactaatcgt
    34861 ggtaaaaaaa tgttaaaagc agtggaaata atgcaagaaa taggaatcga atatatgctt
    34921 gaacatggtc aacaagaaat tctagataat aaaggaattt gctacaataa gtaatcctat
    34981 acataccaaa aagtaagtaa tttacatttt ttacaatagt attataataa aaataaatag
    35041 gaggtataat catgtctata gctttaatat tgattgatat tcaaaatgat tattttaaaa
    35101 atggaaaatg tgaattattt caatcagaag aaactgctga aaatgctaaa aaaatactac
    35161 tgttttttag aaaaaacaat ttaccagtta ttcatataca gcatatatca acagataaaa
    35221 cagcttcttt ttttcttcct aatactcatg gttcagaaat aaataaaatt gtttttccac
    35281 tagataatga agaaattata actaaacaca caccagatag tttctttgaa acagatttgc
    35341 aaagtatcct tgagaaaaaa aatattacta atctagtaat ctgtggaatg atgagccata
    35401 tgtgtattga tacaagtgta agaacagcaa agaaacttcg atacgacata actctaataa
    35461 gcgatgcatg tacaacgaag aatttatctt ggaataatat agaaattaat gcaaatactg
    35521 tacatcaagt attcatggca tcactacaga acagttttgc agatgtaaaa aacacagata
    35581 aatttttatc taactatcac aaataaaaac atacactatg ttaaaagagc aagtttgatt
    35641 tatttaagct tgctctttaa tcatttaaaa ttagatgctt tctatcattt ttatatacat
    35701 aatatacgtt tataca
//
LOCUS       DAEQCW010000032        35403 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.032, whole genome shotgun sequence.
ACCESSION   DAEQCW010000032 DAEQCW010000000
VERSION     DAEQCW010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 35403)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35403)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35403
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.032"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            640..1491
                     /locus_tag="KRO40_001572"
     CDS             640..1491
                     /locus_tag="KRO40_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBH2092393.1"
                     /translation="MEINKKHFIQVFLTCLILVVICEFIGQRTIAIGKASIVLFPMLY
                     AVIIGLIITPDLLGKKIKALKKVVGEKEINIAGEVVGIALVMLGIKYGTTVGPNIDKI
                     IQAGPAFIAQEFGHILAPIVALPLALMFGMKREAVGATASISREPSLGVISEKYGINS
                     PEGSGVLGTYLMGTVLGTIYFSVLGSISIYSGLHPYALGMACGVGSGSMMTAAAGSLS
                     TMVPPEMADTILAYAATSNMMSSITGIIFLVFVSLPFTNFMYKILEPKFSRNKKTKEI
                     KSTEGEC"
     gene            1495..1965
                     /locus_tag="KRO40_001573"
     CDS             1495..1965
                     /locus_tag="KRO40_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092394.1"
                     /translation="MFANLNLKKSSYQLLVMSVIGVIILIGQRISVGTSIVTALPGMV
                     MLILAAMAAMIIKDLFPKSIFPAFGFATIIGLLLSMPYSPTSEVFLTNTNNINFMAIT
                     TPLLAFAGISVGNKIEALKEMSWKIVIISLIVFTTIFFACASIAHIVLSIQGKI"
     gene            1978..3288
                     /locus_tag="KRO40_001574"
     CDS             1978..3288
                     /locus_tag="KRO40_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2092395.1"
                     /translation="MNKEQLKSLVIKTIDENREKILKIGQGIYKNPEYGYKEFKTTEA
                     VSNFFEQELNLSVEKNIAVTGCKADANSSKKGPHISILGELDGISCKEHKDANEIGAS
                     HTCGHNIQIAGMLGAAVGLVKSGVLEHLDGKVSFMATPAEEFIELEYREQLKKEGKIT
                     YFGGKQELIKRGYFDDIDISMMFHASDLGEDKALVGPESNGFVGKKVKFIGKESHAGS
                     APHDGINALNAAMLAINNVNALRETFKESERVRFHPIITKGGDIVNVVPADVHMESYV
                     RARTINGMIDANERINKALMAGGMAVGADVEITEIPGYLPILRYKSLDNLFKNNLEDL
                     GLKGKVIDGGDFTGSFDFGDVSHIMPTLHPMIGGVKGALHTRDFEIVDEDLAYIIPAK
                     AMALTVVDLLFDNAKDAKDILDTFTPVMTKKEYLTFLEKHDKTL"
     gene            3500..4246
                     /locus_tag="KRO40_001575"
     CDS             3500..4246
                     /locus_tag="KRO40_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2092396.1"
                     /translation="MFNAGNRIINTWLYPIQDGFVLIDTGYENGFKHFKKRISKFNIK
                     IKDIRYIFLTHAHDDHVGFLNQILDESPNTKIVMHDKALEILYKGQNSFIGGCTSRTA
                     FLFCQIMKLFGKGEHSFSPLKQEFEKRCILVSDKNRKEIEKELNGKIIDTPGHTDDSI
                     SLLIDDGVLFCGDSAMNGFPSTHKITIFAESKLEFIQSWKTIINTKPKMIYPGHGKPF
                     EYSKLEQNLIYVNKINLYPLHNSKDIHRFL"
     gene            4608..6149
                     /locus_tag="KRO40_001576"
     CDS             4608..6149
                     /locus_tag="KRO40_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH2092397.1"
                     /translation="MNDNVVKKKNFFDRTLNRIETVGNKLPDPVTIFLGLCVLLLILS
                     SLVGSMGISVVHPGTGETITAVNLLTVEQLQILLGNIVSNFQGFAPLGLVLVTMIGAG
                     VCDKTGLMTATIKASVSKIPETRVTLVVMTIGMLANIASDAGTILFPPLAALVYLGVG
                     RHPLIGLFSGYAAVCLGFAANIMISVNDILAASFTVPAAQMIDSGFQANATMNLFFMI
                     ASTFVLILLATWVTEKIVAPRFGKYEGNAELDVDGSLSDVEKKGLKKAGISILIYVAI
                     IVALSVIGKKPFLADPETGDLLSNNAPLMKGMVPIIALAFFIPGVVYGKTIGKIKKDK
                     DVVSIMASAMSDMGGYIILAFAASQFLQLFTNSNLGLILAVKGGEFLKSAGINGPLLL
                     IGFIILSCFINLFIGSASAKWAILAPIFVPMFMMVGYNPALTQMAYRIGDCITNPLSP
                     LFPYFPIILAFTRKYDKDAGMGTVIANMIPYSISFLIVWTILLILFMVFNIPLGPGIL
                     PSYSM"
     gene            6184..7290
                     /locus_tag="KRO40_001577"
     CDS             6184..7290
                     /locus_tag="KRO40_001577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2092398.1"
                     /translation="MLDKNRLINNFMDMVRIDSPSNQELEMSKWLVNYLKERNIDAII
                     DDAGEKYGGNTGNVIAYIKGEEGSRPLCLCAHMDQVQPCLGVKPILDGNVVRSDGTTT
                     LGADDKAGIAAILEALEHVITEKIPHRDIYLCFTICEEAGMHGVKNFNPDNLPCKDMV
                     ILDSGGAIGSIAYKAPAQQSIKISFQGKKAHAGIEPEKGLNAILVASHAISNMHIGRI
                     DSLTTSNIGEIEGGGATNIVTDKVTLTAEIRSHIPETLEYELNHMEKCCKDAASKFNT
                     TYTFEHNMSYPSFELSRDSHVFKLSEEAIRQVGVVPNPMVIGGGSDANILANLGYNCA
                     ILSLGMYDVHTVNEYVNIDELYDTAKIVYHMIKL"
     gene            complement(7669..8955)
                     /locus_tag="KRO40_001578"
     CDS             complement(7669..8955)
                     /locus_tag="KRO40_001578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH2092399.1"
                     /translation="MIVGIIGPSDSGFKIKDDLKQIDSDLKTKIYVREKVVDTIEVIS
                     KCEDECDAIIFTGCAVYEFIKSKYEISKPHSFVPRSGTSIMKAFWAIKSANIKLDKFS
                     IDVVDRYVVEDALKEFDIKATSVFCNPFSLEVGESELVEWHIKLFEENKTDIMLTGFG
                     AVYNELKERGYPVFRLQATIQLIKESYDKVKSEYALSKARFSQIAVEILSLIDYKEKI
                     DNYYSDMIKKSDMDKLVVNYVRSIQGSLFLLGRNDYVVFVHKGVADNEYNYDKLFNLK
                     REIKDMGFSLSIGIGTGVTAYQAENNAHKALRHSIDSKEIGIYLVDEDENIRGPLASE
                     NELNYSLMLSDEKVIEISKKTGMSCESVAKIIAINENRKSKIYDSKELAEYLNVSERS
                     ARRILNKIVNAGLGRICAKETSIGGGRPKNITEILF"
     gene            complement(9078..12176)
                     /locus_tag="KRO40_001579"
     CDS             complement(9078..12176)
                     /locus_tag="KRO40_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH2092400.1"
                     /translation="MDVINLIDELDEIVYVSSLDTYELLYINEIGKKAMGLNDISHLK
                     CYKALQGKDSPCEFCTNSILKEDEYYIWENTNTRTNRHFILKDKLIKWEGKHARLEIA
                     LDITEKEDISKSIAEKLEIKELLVGCIKHLITESNFSDAVNLVLTNIGKFHKADRAYV
                     FEVSEDRKKVTNTYEWCNEGVDEQKQALTNLDINELKNWFLLFEQKGFVIIDDIENIK
                     EEQPIEYEILKPQKIESLMTSSLKQDDKVVGFIGVDNPHKAVGDTSLLTSLSYFLLTE
                     MKKRKVENKLNYMSYYDFLTGAYNRNKYIKYIDNFQKGKVKSIGVVFVDINGLKDIND
                     NFGHANGDSAIVSACVIIKKYFHSYNVYRIGGDEFVVLCEDISKQLFEELVSWLSEEF
                     KDEMIYSVAVGSIWSDDNIDIHKLIKVADERMYQDKKRYYNKNKLRNNEMKVISDLAD
                     STNNILFKHKELVDKVYFDDLMIKGYSKAYEKLAYNTYDIILSICIDTNLITPIYQSE
                     SNIFSFPIKENLEKTFSYIKKHLIHPDDIILFNDNHLLKSLASLNNSKQDDLELNFEY
                     RRLGIDKKYYWALIYMLKISSKNKLGEKQTHILVAIKNIDYLMQLHKNQKDTLTGLYN
                     YESFCEQISLMLKRYPDKRYAIIMMDIDKFKVINDIYGVRGGDKALIYVAELIQKNIG
                     SNGICCRMYADVFCIFYESYSDRDIHKVIYKIKNSLNRKKFEYMLVPCFGVYRILDNH
                     IPITNACEMAGYAHKKVKKQSINNYIFYDDTIRNDALEEKQMEREMEYALENGQFHVY
                     LQPKYNLNANKIVGAEALVRWVHPEKGIIPPIKFISLFEKNGFIIRLDMYVWEQVCSL
                     IRKWIDLGEEPVPISVNVSRLHLHNPHFKEIVLSLINKYSIPKSFLELELTESLFIKN
                     IKLFTKIIADLRMDGIVLNMDDFGSAYSSLNMLKNINIDTLKIDCGFFNEEGITDREK
                     IVLKHTIAMAKDLDMDVVAEGVETKEQAEFLVSLDCVVIQGYYYCKPIPSADFEKLLY
                     QK"
     gene            12902..13060
                     /locus_tag="KRO40_001580"
     CDS             12902..13060
                     /locus_tag="KRO40_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092401.1"
                     /translation="MKIFSFLLFVIGICLCIAGFIGHYPVFVGTTLSFLAIAMIAVRQ
                     VKTKKKMK"
     gene            complement(13347..14051)
                     /locus_tag="KRO40_001581"
     CDS             complement(13347..14051)
                     /locus_tag="KRO40_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092402.1"
                     /translation="MEIKPLVLIVEDDKPICKFIKVSLETQNYRCVETDNGGTAISLI
                     HSLDPDLIILDLGLPDIDGIEVIGRVRACAKTNKIIVVSAREHERDKVEALDGGADDY
                     LTKPFSVTELLARVRVALRNKAQQDNINNDAPKSFEVKNLKIDYENHIVSINGEEIHL
                     TPIEYKIIELMSKYSGRVLTHKFIIDKVWGNYYESENQSLRVFMASIRRKIEKNPAQP
                     EYILTEVGVGYRMADE"
     gene            complement(14042..15649)
                     /locus_tag="KRO40_001582"
     CDS             complement(14042..15649)
                     /locus_tag="KRO40_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4118 domain-containing protein"
                     /protein_id="HBH2092403.1"
                     /translation="MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGI
                     SVVFEKVGFNESNIILVYILGVLFATSITYGYFFGILSSVIGVLSFNFFFTHPLYTFL
                     AYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
                     QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEA
                     FRTGNPVGIGTKYCKNSSAYYFPIKGQESNVLGVIGVACFKIDIITENEKILLEAVST
                     QVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLTSILGSSSTILENDD
                     VIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILR
                     VKKFANSRDIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESN
                     QVLFEVADNGKGIPNEDIGNIFNRFYTKNKSRNLERRGIGLGLEICKSIVEAHGGEIV
                     AFNNPSGGATFRFSIPMYDEEGKDKWK"
     gene            complement(15903..17081)
                     /locus_tag="KRO40_001583"
     CDS             complement(15903..17081)
                     /locus_tag="KRO40_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092404.1"
                     /translation="MEKLSDKRRVKAVSMETFVFIVLLAVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLDTVFLIMAMAVLAGALSALLSEFGVISLVNKIFKGLMRPIWGLPGASIA
                     GVVATYLSDNPAIIPFAKDKTFTQYFKKYQVPALCNLGTAFGMGLIVTTFMIAQGKEY
                     VLPAIIGNVAAIIGSIISVRIMLTFTKKYYNYDPKNDTEKQINDKGAKLEEFREIRDG
                     NVFQRTLDAILEGGKLGVEMGMAIIPGVLVVCTLVMLLTFGPSTDPATGQAVYTGAAY
                     EGIKLLPAIGDKISFIIEPLFGFTSPEAIAFPVTALGAVGAAISLVPEFIKSGAITPN
                     DIAVFTAMGMCWSGYLSTHIGMMDALDARPLAGKAILSHTIGGLCAGICAHFIFMLVG
                     "
     gene            complement(17307..17801)
                     /locus_tag="KRO40_001584"
     CDS             complement(17307..17801)
                     /locus_tag="KRO40_001584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH2092405.1"
                     /translation="MHLFIEVIAAFFTALSFGVLFNMKGKNLILAGIGGSIAWFSYKF
                     LLNMGVTENLCFFIATVCFAIYCELCARIYMTPATTLSVCCLIILVPGYGIYNTMYSV
                     LTNNYIKAVEYGVSTLSCASSIALGLVFITTVFRKVNLYGVLTKIKENEKYKKSINKI
                     KQQK"
     gene            complement(17802..18563)
                     /locus_tag="KRO40_001585"
     CDS             complement(17802..18563)
                     /locus_tag="KRO40_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBH2092406.1"
                     /translation="MDIDRILNFSSNAGKAMLQSGGETYRVEETIARICQSFGIDHVD
                     VFATPTAVMASVFVDGKLHSAIKRISSRRVDLNLVHEVNSLSRAISINNLDIELCEKI
                     LDEISEDNYYSDLITIFFAGIAAATFSILFGGNVEEFIAAFTVGILTKFVIMYLSKSS
                     LNDFFVNAIGAVIIASCSILILKLGFIKTLDHLIAGAIMLLVPGLALTNALRDLLDGQ
                     LISGLAKLAEVFFVGVSIAVGMFLVLGLYFKLGGI"
     gene            19265..22099
                     /locus_tag="KRO40_001586"
     CDS             19265..22099
                     /locus_tag="KRO40_001586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092407.1"
                     /translation="MLRKDKVLLSLHKLCENMTLKDLQSDKTGFTTIEIANHSSLDRS
                     NTSKELNNLYNEKKVLKISGKPILFLHASIIENLIGRTLNSDEFSINNCNELLKSSKN
                     DSEDIFSTLLGHDSSLKLPIEKAKSAILYPPKGLNTLLIGPTGVGKSTFAETMYKYAV
                     ESKIFSSESKFVVFNCAEYAENANLLLSNLFGYVKGSFTGANKDKFGIVAQADGGILF
                     LDEIHRLPPEGQEMLFLLMDKGIYRRLGESDIVHKANVFIVCATTEDIHSSLLGTFLR
                     RIPVTINLPALQDRSLKERLSLIKYFFIIESKYTNATIKVHKDVIKSLLLYDCFGNIG
                     QLKSDIQLMSARAFLNYKTGLKDNIEIDLSIVPDYIYIGLLKLNENRSNLNKLSELDY
                     MLFYEFNGNNLEVEYTKELSKYNIDTSNNGFKYSTEIPYLENDIRSMFINYMEKYSTK
                     LLSISSVTHSDYTSNEIFKVINPKIYYAVEHSLKEAEKISRNKYTKQTYIALSMHISA
                     LIENINQDTYNPKYNLYNDKIFLDKDLNIAKIVLSIIENDLQTSLPKDEVKFISMFLN
                     SMYLEPNNQSESIGVIILAHGNSTASSMCDVANSLLGTNHCNAIDMPLDVKVSTILDK
                     TIELVKECDEGKGVLLLTDMGSLIAFGELISEKTKIKTRSIEMVSTPIVLEAVRKSTL
                     PEMTLDELANSLSSLNPYIGRAAIDSTEINYPEKSREYVIITTCITGYGSAMKVADFI
                     NSSLKNISKYNINLVPHNIESFKMYKNKFSNTKILAVVGSVDFNVANTPFIHIEELLN
                     GYGLDMLNKIIEGTFNANSITNIKETNLSYNSLIINFMTQNLELLDSVKLFNYVNSSL
                     FTIIELIDENLKSKFKLGYILHCSFMIERCFKNTTFPYNNITELISKNHELYSLIREA
                     FKPTEAYFNILIPDEEIAYIIDMINEYLNK"
     gene            22142..23386
                     /locus_tag="KRO40_001587"
     CDS             22142..23386
                     /locus_tag="KRO40_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH2092408.1"
                     /translation="MEDEILKGKIKQLTILALIFIFITPVFAFADTPPVPNSSRAALL
                     IDQETKRILFEKNIDEKMPLASLSKMMTFLLAIEAVDKNQVKETDMVKIDKSTASVGG
                     STCKLKDGDEISLGELMQGLMLVSGNDAAIAIAKHIGKTEKNFVNMMNKKAEEIGMID
                     TYYFNPNGLPIYTDPEHKEPPIENMSTAHDIVTLGKYMYDHYENQVTRITTMQVYNDT
                     KKDFTHYNTNPLLVSVPGVDGIKTGYTDNAGYCLAFSMMVPKDAKNERNHRLIGVVLG
                     DGNKKNRISSSATLLKYGKDNFHSKKIAHKGDIIETPCVDGIDDFKITVKVDKDLYGV
                     VSDNENINPKVVFKNMNYPIHKGDIVGVAKYYNDSGKFVGSVDVKSESNIGCIPLKDK
                     IKIKVAKINKKLEIKNSVCFKA"
     gene            complement(23801..25543)
                     /locus_tag="KRO40_001588"
     CDS             complement(23801..25543)
                     /locus_tag="KRO40_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092409.1"
                     /translation="MKKTINNNLFRILNIIVYKNKTKLIVSFIMVFIIAGVNIVIPQL
                     IRCIIDDGIGNKNIFLLINLILIYIFIRILSATFDVILSYLYTSIKNKVTINLKVKLL
                     NHISKLSGRYYSSKKTGNILSIMESDIFMIENFGAEIIFDIIVNVFTAIISLIFLINL
                     QFDLFLVVLFLQLILTFSQNKMTKLISKKISEIRSDSGSLSNLIQEYVSNIMDIVILN
                     SKKNFFNKYLKRERDLIKKDLNLNIIMSSNIAISQILTGLITILIYGIGGYKIINNKM
                     TMGELIAFQQYTGMLIGPCIAIVRANTRIAQSKVSINRVFSVIDEKIDIKVDNNGYRI
                     DNSEIKKIDFKNVSFRYGEDLNLVLNDINLQFEKGEVTGIVGGSGCGKSTITNLIYRL
                     WDINEGDILIDGVNIKDINLKSLRNNIDIVTQDQFVFDDTIKNNIVLNNKISDKELDE
                     ILEVTCLDDFIKNLDKGLDEVVGEKGVKISGGQKQRISIARALVSNKKVLILDEATSA
                     LDNISQKEILNNLKEYIQDKIVIIIAHRLSTIKSADNIYVLDKGRVIESGNDAELLHK
                     DGLYNKLVETADFA"
     gene            complement(25527..26201)
                     /locus_tag="KRO40_001589"
     CDS             complement(25527..26201)
                     /locus_tag="KRO40_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092410.1"
                     /translation="MKILKVKDLKKIYGKYENEVRALDGIDLDIEPHKFTAIVGASGS
                     GKSTLLHCVAGLDKPTLGNVYLDDVDLYTLNDDKLSEIRRQEFGFIFQSYNLIPVINV
                     YDNIVLPVLLDGKKEDKEYVMRLINKLGIEKQIKKYPNELSGGQQQRVAIARALANRP
                     SVIFADEPTGNLDSKTTNEVMNMLEWCVKEYKQTLVMITHNDNIAKTADRIITIKDGK
                     IDEKNY"
     gene            complement(26238..27227)
                     /locus_tag="KRO40_001590"
     CDS             complement(26238..27227)
                     /locus_tag="KRO40_001590"
                     /inference="COORDINATES: protein motif:HMM:NF012311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBH2092411.1"
                     /translation="MTKVRIAVLDTGLDVNDDDINGNYVYDSNFQLKDLGGKEINDIN
                     GHGTFVSKTILNISKNTQIYPINIFNDSGKTSSLNLLSTLSKLTMSDIQIINISAASI
                     NSMYEKELEKVCNILNSQGRFIICSKHNKYEDKESIPTIFESVIGVVGNENIYKNNQY
                     IYEPENKIQMYANSKDNFIKFKDKVTHFGKNSKACAVATGIVANILKNNPYIKFNELE
                     EILIQKSKSKEDLKIENLNTPSYKSNLIRLDIARKIINVINRNFSKIKIDFEFVSEYS
                     LFNNFTCIGNYNAYNFLTILNKEFNISIDYKEVYLYQLENLDMAVDLIYENLI"
     gene            complement(27275..28519)
                     /locus_tag="KRO40_001591"
     CDS             complement(27275..28519)
                     /locus_tag="KRO40_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092412.1"
                     /translation="MNSSNKYFLDCICEKIINNNQVILSNKVNGRWVKIPIECYEVLK
                     YSVDNALQLGNLYDVFQENEDKKYYERVIDKLEHIGLLSDSILSEFRLERINKISFSP
                     TNRCNLSCDYCCVDSKIDNNDYLDTSQVRKVIDNIVKLNPRILTITGGEPLMRNDFLE
                     LLDYIKEKFKGKIILSTNATLIKEKQIDDIINGLYAIEISLDGYDELSCSEVRGKGVF
                     CKVLNVIRLIKLKKFENVGLSMVVGKNNEKDIEKFNKLNEDLGTTPIIRNFMNIGRGN
                     ENYSKYLNDKLDIDYICKDDYVDESSLCSNMCKAGVNQISIDHKGDVYPCPNLEYKDL
                     KIFNILEFNENILERILNREMDIFNIFDKLKPVNIESCKECKVNLFCTTCPSKIYTLK
                     NNKKMFDANCKKMKNILEPILW"
     gene            complement(28561..31107)
                     /locus_tag="KRO40_001592"
     CDS             complement(28561..31107)
                     /locus_tag="KRO40_001592"
                     /inference="COORDINATES: protein motif:HMM:NF014717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092413.1"
                     /translation="MINIKLAVSYLKRQKGKTLSLILSIGIAVMLVFSLSVINESQGQ
                     SDINHAYKNSGDYHAFYEDINSDIVKELNGEEDIKEFNDVLKFGEIISKDNGASLNLC
                     SYNKDFLDSTRYKLVKGREPRTSNELVIEQKVLDKMELDVKLNQTIDFQIVNEHINKN
                     NENSIYSKDKQFKIVGILSKSDEYYENLNKYKVRAFTYSNNGKDIVPYELITHMGTLK
                     LNTKDLDSQKVVNLGRKYKLTSNQFYPNTEVSMSMYMKNISKKTTYSIKQSLLPLLCA
                     TLVIYNMFNIIILDMTKQIGLLRAVGASKRNIRQVFFIQSIVVLSVGIVIGLLGGIVF
                     SYLGLMIVYDKSAELTINTNSIIESIIMSIIAVILASVVPIYKAGNLSIIDAIKKTDK
                     LNYIPRLLLLKSHKKVVGIINEIAFKNIFRNKVTSIIIIITISLCGVLFIGRLTSTKF
                     IYGKESDSANITSKSYGNFDIYLGYSPINANYTFSKYDNSLLNEIKAIEDVTDVEPNI
                     YLKGYLRNADLEEDYLDELKRTEINNNNESTVLIRGYNKELLNNIDKYIDKGENVYSY
                     TDRDYKNVLLVNNFYSRIKLSNNTQIIKSPKIGDLIDIKIPVYKDGEYKYINTKVRIA
                     GIMKNSYISEQDGESQSGGIQIIFNEKDLKELTGISDYNKVFVKIKKETDKKVIKEIN
                     NIIEKSGFSDIEGRYVRNHFGDHYNKSSYKLAMICVFGVLLISSINIIFIVRSNIIVR
                     LSEICTFRAIGMSKKNVKRMLIKENMIYGVLSMIVAGIISSFNYYKIVSETNKLNQQV
                     YGINNSIKFEIPIYEILIFGSISVFVCVIAVYFSNKMINKLSIVSGIKEN"
     gene            complement(31315..31476)
                     /locus_tag="KRO40_001593"
     CDS             complement(31315..31476)
                     /locus_tag="KRO40_001593"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092414.1"
                     /translation="MIHIKKIEEKIELQDVEVQADPCKWYYDKHGIISQIDCMVDCAG
                     STPKGTVAY"
     gene            complement(31532..32548)
                     /locus_tag="KRO40_001594"
     CDS             complement(31532..32548)
                     /locus_tag="KRO40_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092415.1"
                     /translation="MKFTIFVTEDCNLRCTYCYEGNDKKKENMSYETADKTIDFICNK
                     ELESNSDYTTIVLHGGEPFINFDLIKYIHRDLVDRLSDKKILFDITTNGTIINDEIIE
                     FIAKNVKNISISIDGKKNIHDINRIDANGVGTYEKVMENGKRLIDKGIYVRARMTYNS
                     NTVKYLYESVYDIAKQGFKNIAPISDFMDKNWDNSHIKILNEQISKIMNIKKDYPEID
                     ISILDKQFINKKKGDCFGGINSYAIDTRGDVYPCTVCVGDKDILLGNIYDGLDDKKIK
                     NLIKIYISKNEECDGCTRLDYCMSTRCKLINKKVTGKFQSAVPIYCGLERVYVETTKK
                     LCSL"
     gene            complement(32545..33843)
                     /locus_tag="KRO40_001595"
     CDS             complement(32545..33843)
                     /locus_tag="KRO40_001595"
                     /inference="COORDINATES: protein
                     motif:HMM:NF015983.1,HMM:TIGR04085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092416.1"
                     /translation="MIDSEEMIFNVEDLIIYRKNQLVIIYNKKFRKYIKLSEEIYKYF
                     LLGQENKIKIYDFVNYFDDESDKKYIINLIDIMNKNQIFKSNNLNFDMLSNGVAIYFC
                     LTNRCNLFCKHCCVESSSNKKDLLSTYDLKNIVDIISVLNTPHIIITGGEPLIREDFF
                     EIIKYIKQKLPDTKLILSTNGTLIDEHNVDFIITNFEKIDISIDGVDENTCSETRGKG
                     VFNKVISSVNLLKDNGFSNIKLSMVFGQKNSHLNKQFKDLNKKLGTEFVERYFIPTGR
                     GLENKESYLIEDTVLPITIPYILDNELKMCKDKKNKKMGCCACNAGNSQIFINYDGDV
                     YPCPSLIKDDYKMGNIFDNEFVKVIKENKTRDLKSLIKLESIYPYNFEKCKDCDVNIF
                     CWHCPAILDSVKDNELELDRWCSMMKHNLNTAVWGDEKVN"
     gene            complement(34309..>35403)
                     /locus_tag="KRO40_001596"
     CDS             complement(34309..>35403)
                     /locus_tag="KRO40_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2092417.1"
                     /translation="YKINYVVDKWKSVFISLLYWMLLIGFDSIGLSIVMTLNSIKNMN
                     DLLEDNLLKLELIMISKSLLIVLIPLLKFIRLKTKINKRDCIYLSIPLIANIIGVIVI
                     FEFIFKDKIIDSKESLIILTISTVFLLSNLSLVSIIGRIIKDNSLKIEYEITKKRMNM
                     QYKYYLNLQEYQLKIRKLYHDMNNHIICIQNVYGKNEFADKYIKDINKQIKECNTIFN
                     TQNMILDVILSDKKSICDMNNIYFLVDINFLECNFIEMPDICSIFSNIIDNAIEACIK
                     IKDTSIQKKIKLRGTVINRLFVIKCENTKINEVVLKNNKVITSKKDSFLHGIGISSVK
                     SSVEKYNGNVEIYSDKNKFTITIYIPLTRN"
BASE COUNT        12213 a         5548 c         4033 g        13609 t
ORIGIN      
        1 tatatcaatt tacttattat catctcattt gttatcgtct tacttaattt acttattgct
       61 atgtcaattc atttattatt atctcacttg ttatcgtctt acttaattta cttatttcta
      121 tatcaattca cttattatca tcttaattca tttgcttatt atcatttact ttattcaatt
      181 tctatatcaa aattagtatt tgtacttaat acttaaaatt aatttaaagt ctttacatat
      241 tatttatttt ctattgtaat attcatttcc atactttact aagctacttc cactcattta
      301 ttttaaaatt tcaatttact atttctcaac tctatattat tatttttcaa ttttatatta
      361 ctaattttaa agctttttag ctattattcc tacaatattt aaacaatttt ttcataataa
      421 agctatatta caatatattc aaaatatgta atattttaga tatttttcgt tgacaatgtt
      481 aaatttttgt tttatcctta attaaggaca tgttattgac atttctgaaa cttatttgaa
      541 atagtttttt cattttattt aggaaaacgt attatactta agaaaacgta ttttctcatt
      601 tcagataagt aaaatattta ttcttttggg gaggaaatca tggaaattaa taaaaaacat
      661 tttattcaag tatttttaac ttgcttaatc ttggtagtaa tatgtgaatt tatagggcaa
      721 agaactatag ctattggaaa agcctctata gtactgttcc ctatgcttta tgcagttata
      781 attggactta taataacacc agatttatta ggtaaaaaaa ttaaagcact taaaaaagtg
      841 gttggagaaa aagaaataaa tattgctggt gaagttgttg gaattgcact agtaatgctt
      901 ggtataaaat atggtactac agttggacca aacattgaca aaataattca agctggacca
      961 gcgtttatcg ctcaagaatt tggtcatata cttgcaccaa tcgttgcatt acctcttgca
     1021 ttaatgtttg gaatgaaaag agaagctgtt ggagctactg caagtataag tcgtgaacct
     1081 tctttaggag ttatatcaga aaaatatggg ataaactcac cagaaggtag tggtgtactt
     1141 ggtacatatt taatgggaac agttcttggt actatatact ttagtgtact aggttcaata
     1201 tctatttata gtggtcttca cccatatgct ttgggaatgg cctgtggtgt tggtagtgga
     1261 agtatgatga cagcagctgc tggttcatta tctaccatgg taccacctga aatggcagat
     1321 acaatacttg cctatgctgc aacaagcaat atgatgtcta gtataacagg aattatattc
     1381 ttagtttttg tatccttacc atttactaat tttatgtata agattttaga accaaaattt
     1441 tcgagaaata aaaaaactaa agaaattaaa tctacagaag gagagtgcta ataaatgttt
     1501 gctaatttaa atttaaagaa aagttcatat caattattgg ttatgtctgt tattggagtt
     1561 ataattctta taggacaaag aattagcgtt ggtacatcta tagttacagc tcttcctggt
     1621 atggtgatgc taatattagc tgctatggca gctatgatta taaaagattt atttcctaaa
     1681 tcaatctttc cagcttttgg atttgcaact ataatcggcc ttttacttag tatgccatat
     1741 agtccaacat ctgaagtatt cttaactaac actaataata ttaactttat ggctataact
     1801 actccactac tagcttttgc aggaatttct gttggaaaca aaatagaagc tttaaaagaa
     1861 atgtcatgga aaatagttat aatttcactt attgtattta caactatatt ctttgcatgt
     1921 gcgagtatag ctcatatagt tttaagtatt caaggtaaaa tataggagga atttattatg
     1981 aataaagaac aattaaaatc tctagtaata aaaactatag atgaaaatag agaaaaaata
     2041 ttaaaaatag gtcaaggaat atacaaaaat ccagaatatg gatataaaga atttaaaact
     2101 acagaagctg tttcaaactt ttttgagcaa gaattaaatt tatctgtaga aaaaaatata
     2161 gcagttacag gatgcaaagc agatgcaaat tctagcaaga aaggtcctca tatatctata
     2221 cttggagaat tggatggtat atcatgtaaa gaacataaag atgctaatga aataggtgct
     2281 tctcatactt gtggacataa tattcaaata gctggaatgt taggtgctgc tgttggttta
     2341 gtaaaaagtg gcgttttaga acatttagat ggtaaagtat cttttatggc tactcctgct
     2401 gaagagttta ttgagttgga atacagagag caattaaaaa aagaaggaaa aataacttat
     2461 tttggtggaa aacaagaatt aataaaaaga ggttattttg atgatataga catatctatg
     2521 atgtttcatg cttctgattt aggagaagat aaggctctag ttggtcctga gagtaatgga
     2581 tttgttggaa aaaaggttaa atttataggt aaagaatctc atgctggttc tgctccacat
     2641 gatggaataa atgctttaaa tgcagcaatg cttgctataa acaacgtgaa tgcacttaga
     2701 gaaactttta aagagtctga aagagttaga ttccacccta tcatcacaaa aggtggagat
     2761 atagtaaatg ttgttcctgc tgatgttcat atggaatcat atgttagagc tagaactata
     2821 aatggtatga ttgatgctaa tgaaagaata aataaggctt tgatggctgg tggaatggca
     2881 gttggagctg atgttgagat aactgaaatt cctggatatc ttccaatatt acgatacaaa
     2941 agtcttgata atttatttaa aaacaatctt gaagatttag gtctaaaagg aaaagttatt
     3001 gatggtggag attttacagg ctcttttgat tttggagatg tgtctcatat aatgcctact
     3061 cttcacccta tgattggtgg tgtaaaagga gctcttcata caagagattt tgaaatagtt
     3121 gatgaagatt tagcttacat aattcctgct aaagcaatgg cacttacagt tgtagacctt
     3181 ctttttgata atgctaagga tgctaaagat atattagata cctttactcc agttatgact
     3241 aaaaaagaat atctaacatt cttagaaaaa cacgataaaa ctttataagt ctatttttat
     3301 aatagggtgg tatctactgt aaaagttata ccactctttg tttttgtaac agtatacttc
     3361 ttttctttta gtttttagat taaactaaaa tatattatcc tccttaaaac ttttagagct
     3421 acgttgaaat atcagtagaa ctatgctata ttctttctaa ttaatataaa tttctattct
     3481 aattcaaggt ggtgaaaaaa tgtttaatgc aggaaatcga attataaata catggttgta
     3541 ccctattcaa gatggctttg tcttgattga tactggatat gaaaatggtt ttaaacattt
     3601 caaaaaacga atttctaaat tcaacataaa aatcaaagat attcgataca tatttctaac
     3661 tcatgctcat gatgaccatg ttggttttct aaatcagatt ctagacgaat ctcctaatac
     3721 aaagattgtt atgcatgata aagctttaga aattctatat aaaggtcaaa actcttttat
     3781 tggtggttgt accagccgta ctgcctttct cttttgccaa attatgaaac tatttggaaa
     3841 aggtgagcat agtttttctc cacttaaaca agaatttgaa aaaaggtgta ttcttgtgtc
     3901 tgacaagaat cgtaaagaaa ttgaaaaaga actaaatgga aaaattatag atacaccagg
     3961 acatactgat gattcaattt cactactaat tgatgatggt gttttatttt gtggagattc
     4021 tgcaatgaat ggatttccaa gtactcacaa aattaccata tttgcagaaa gcaaactaga
     4081 atttattcaa tcttggaaaa caattatcaa tacaaaacct aaaatgattt atcctggaca
     4141 tggaaaacca tttgaataca gtaaattaga acaaaatcta atctatgtaa ataaaataaa
     4201 tttatatcct ctacataatt caaaagatat tcacagattt ttgtagaaaa tacaaagtaa
     4261 atttctttga ttaattaaaa aatctaacac tttactacgc tacttatttt aataacttaa
     4321 tcttccacta gcttttcata aaattttgtt ttaaaattaa ttttaaagcg catatgttat
     4381 ttaaatacat tagatataat tcgtcattaa tctacttaaa gcatatttaa ctaacaccac
     4441 tcaaccagaa aattcagaaa actgcattga cacaggaaaa agtttatttt atactttttt
     4501 taggacatat tgtggacacg tcttaaatcg acaagcagaa tttaaattgt aagattaacc
     4561 acaatactta ttttttaatt atatttttaa acattaggga ggatattatg aatgataacg
     4621 tagttaagaa gaaaaacttt tttgacagga cattaaacag aatagaaact gttggtaata
     4681 aactaccaga cccagttaca atatttttag ggttatgtgt acttttactt atactatcta
     4741 gtctagttgg ttctatgggg atatcagtag ttcatcctgg tactggagaa actataaccg
     4801 ctgtaaattt attgactgta gaacagcttc aaattctttt aggaaacata gtcagcaatt
     4861 tccaagggtt tgctcctttg ggtctagttc tagtaactat gataggtgct ggtgtatgtg
     4921 acaaaacagg acttatgaca gcaacaatca aagcatcagt aagcaagatt cctgaaacaa
     4981 gagtaactct tgttgtaatg actataggta tgcttgccaa tatagcttca gatgcaggta
     5041 caatattatt tccaccatta gctgcacttg tatatcttgg tgttggtaga catccactta
     5101 taggtttatt ttctggatat gcagcagtct gtctaggatt tgccgcaaac attatgataa
     5161 gtgtcaatga tatacttgct gcaagtttta cagttccagc agctcaaatg attgattctg
     5221 gatttcaagc caatgcaaca atgaacttat tttttatgat agcatcaact tttgttctaa
     5281 tacttttggc aacatgggta acagaaaaaa ttgtagctcc tagatttggt aaatatgaag
     5341 gaaatgcaga actagatgtt gatggaagtc ttagtgatgt agaaaagaaa gggcttaaaa
     5401 aagctggtat aagtatatta atatatgtgg ctattatagt agctcttagt gtaatcggta
     5461 aaaaaccatt cttagctgac ccagaaacag gagatttact atcaaacaat gctcctctta
     5521 tgaaaggtat ggtacctata atagcactag catttttcat acctggtgtt gtatacggaa
     5581 aaactatagg taaaataaag aaggataagg atgtagtctc tataatggct agtgcaatga
     5641 gtgatatggg tggatatata atactagcat ttgctgcttc acaatttttg caattattca
     5701 caaatagtaa tttaggtctg atactagctg taaagggcgg agaattttta aaatcagcag
     5761 gaataaatgg acctttattg ttgataggat ttattatatt atcctgtttt ataaatttat
     5821 ttataggtag tgcatctgca aagtgggcta ttcttgcacc tatatttgta ccaatgttta
     5881 tgatggttgg atacaatcca gcacttactc agatggctta tcgtataggt gattgtataa
     5941 caaatccact tagcccatta tttccgtact tccctattat actagcattc acaagaaaat
     6001 acgataaaga tgctggtatg ggtactgtaa ttgctaatat gataccatac tctatatcat
     6061 tcttaatagt gtggactata ctactaatat tgtttatggt atttaatatt ccactaggac
     6121 ctggaatact tccttcatat agcatgtaat ttatttaaat ctttctaaaa ggagaaataa
     6181 tttatgttag ataaaaatag acttataaat aattttatgg atatggttag aattgatagc
     6241 ccatctaatc aagaattaga aatgtctaag tggttggtaa actacttaaa agaaagaaat
     6301 atagatgcca ttatagatga tgcaggtgaa aaatatggtg gtaatacagg taatgtcatt
     6361 gcctatataa aaggtgaaga aggaagtaga ccactttgtt tatgtgcaca catggaccaa
     6421 gttcaacctt gtttaggtgt aaaaccaata ctagatggta atgtagttag aagtgatgga
     6481 actactacac ttggtgcaga tgataaagct ggaatagctg ctatacttga agctttagaa
     6541 catgttatta cagaaaaaat accacataga gatatttatc tttgttttac aatctgtgag
     6601 gaagctggta tgcatggtgt caaaaacttt aatcctgaca acttgccttg taaagatatg
     6661 gtgattttag attctggtgg agctattggt tcgatagcat acaaagctcc tgctcaacaa
     6721 tctataaaaa tctcttttca aggaaagaaa gcacatgctg gtatagaacc tgaaaaaggg
     6781 ttaaatgcta tattagtagc ctctcatgca ataagcaaca tgcacatagg cagaatagat
     6841 tcattgacta cttcaaatat aggtgaaata gaaggtggtg gagctacaaa catagtaact
     6901 gataaggtta cattgactgc tgaaattagg tctcatatac ctgaaacttt agagtatgag
     6961 cttaatcata tggaaaaatg ttgtaaggac gctgcatcta aatttaatac tacttatact
     7021 tttgaacata atatgtctta ccctagtttt gaacttagta gagatagtca tgttttcaag
     7081 ttaagtgaag aagcaataag acaagttggt gttgttccaa atccaatggt aattggtggt
     7141 ggaagtgacg caaatatatt agctaatctt ggatataatt gtgctatatt aagtctaggt
     7201 atgtatgatg tacacacagt taatgaatat gtaaatatag acgaattata tgatactgcc
     7261 aaaatagttt atcatatgat taaattataa atatcataat agaactcttt aaattataaa
     7321 aataaaaacc tatgtatcct caactttata agttatatat tagagttgtt ttacataggt
     7381 tttagtattt ttatataata atttgtttta acatttttca taataagctt tgatatttta
     7441 tatagtaatt tgttctaaca tttttcataa taagcttcaa tattttgcat aataatttat
     7501 tctagcattt ttaataatag gctctagtat tttatattaa taatttattc tagtatttta
     7561 cataattatt tgttctaatt tttttcataa taagctttaa tactttatat agtaatttgt
     7621 tgtagaattt tatacaatat aatgatttat acagttttat aaaatatctt aaaacagtat
     7681 ttcagtaata ttttttggtc ttcctccacc aatactagtc tcttttgcac atattcgacc
     7741 taaacctgca tttactattt tatttaatat acgtcttgca cttctttcac ttacatttag
     7801 atactctgct aactcttttg aatcataaat cttacttttt ctattctcat ttatagcaat
     7861 aatttttgca actgactcac aactcattcc agtcttttta gatatttcga ttaccttttc
     7921 atcagatagc atcaaagaat aatttaattc attttcggaa gctaaaggtc ctcttatgtt
     7981 ttcatcttca tctaccaaat atataccaat ttcttttgaa tctatggagt gtcttaatgc
     8041 tttatgtgca ttattttcag cctgatacgc agttactcca gtaccaattc ctatactaag
     8101 agaaaagccc atgtctttta tctctctctt tagattgaat agcttatcat aattatactc
     8161 attatcagct acccctttat gaacaaatac aacataatca tttcttccaa gtaaaaataa
     8221 ggaaccttga atgcttctta catagtttac tacaagctta tccatatctg atttttttat
     8281 catgtcagaa taatagttat ctatcttctc tttataatct attaaactca atatttcaac
     8341 agcaatttga gaaaatcttg ccttacttag agcatattca ctctttacct tgtcataact
     8401 ttctttgatt aattgtatag tagcttgtaa acgaaataca ggatagcctc tttcttttaa
     8461 ttcattatat actgcaccaa aaccagttaa cattatatcc gtcttatttt cttcaaataa
     8521 ttttatatgc cattctacaa gttcagactc tcctacttcc aaagaaaatg gattacaaaa
     8581 tacactcgtt gctttaatat caaattcttt aagtgcatct tccacaacat atctatcaac
     8641 tacatctata ctgaatttat ctaattttat atttgcactt tttattgccc aaaatgcctt
     8701 cattatactc gtcccacttc tcggtacaaa tgaatgtggc ttacttatct catacttaga
     8761 ttttataaat tcataaactg cacatcctgt aaatataata gcatcacatt cgtcttcaca
     8821 tttagaaata acttctattg tatctactac tttttctctt acatatattt tagtctttaa
     8881 atcactgtct atctgtttta aatcatcctt tatcttaaac ccagagtctg aaggacctat
     8941 aatacccact atcataaact tcgctcctaa tccataaata ttatactttt taaaaattat
     9001 atcctcacta ttttctactt ctatttaatt attttgaact aatccatcct acctacattt
     9061 agaatggaat aattagctta tttttgataa agtaacttct caaaatcagc acttggaata
     9121 ggcttacaat aataataacc ttgaattacc acacaatcta aactcactaa aaattcagct
     9181 tgttcttttg tctctacacc ttctgccact acatccatat ctaaatcttt tgccatggct
     9241 atagtgtgct ttaaaactat tttttctctg tctgtgattc cttcctcatt aaagaaacca
     9301 caatctatct ttaatgtatc aatattaata ttttttaaca tatttaatga agaatatgct
     9361 gaaccaaagt catccatatt taaaacaata ccatccattc taaggtcggc tattatctta
     9421 gtaaataatt ttatattttt aataaataaa ctttctgtaa gctctaattc taaaaaagat
     9481 tttggtatac tatatttatt tattaaactt aaaacaattt ctttaaaatg tggattatgc
     9541 aaatgtaatc ttgatacatt tacagagata ggaactggct cttcacctaa atctatccat
     9601 tttctaatca aagaacatac ttgttcccat acatacatat ctaatctgat aataaaccca
     9661 ttcttctcaa atagtgaaat aaatttaatt ggaggtatta tacctttttc tggatgaacc
     9721 catctaacca atgcttctgc accaacaatt ttatttgcat taagattata cttaggttgt
     9781 aaatatacat ggaattgccc attttcaagt gcgtattcca tttccctttc catctgtttt
     9841 tcttcaagtg catcatttct tatagtatca tcataaaata tatagttgtt gatactttgt
     9901 ttctttactt ttttgtgagc atatcctgcc atttcacacg catttgtaat tggaatatga
     9961 ttatccaaaa ttctataaac tccaaaacat ggtactaaca tatattcaaa tttttttcta
    10021 tttaagctat ttttaatctt ataaattacc ttatgaatat ctctatcaga gtaactctca
    10081 taaaaaatgc aaaatacatc tgcatacata cgacaacata taccattaga accaatgttt
    10141 ttttgaatca actctgcaac atatattaaa gctttatctc ctcctctaac tccataaatg
    10201 tcattaatta ccttgaactt atctatatcc atcattataa ttgcataacg cttgtcagga
    10261 tatcttttaa gcattaaact tatttgttca caaaaacttt cataattgta tagtcctgtt
    10321 aatgtatctt tttggttttt atgtagttgc ataagataat ctatattttt tatagcaact
    10381 aaaatatgtg tttgtttctc acctaactta tttttactac taatctttaa catataaatt
    10441 aatgcccaat agtacttttt atctattcct aaacgtctat actcaaaatt tagttctaaa
    10501 tcgtcttgct tgctattatt aagactagca agagatttta gaaggtggtt atcattaaat
    10561 aatattatat catcaggatg aattaaatgt ttttttatgt atgaaaaagt tttttcaaga
    10621 ttttccttta taggaaaact aaaaatattg ctctctgatt gataaattgg agtaattaaa
    10681 ttcgtatcaa tgcaaataga taaaattata tcatatgtat tataagctaa tttttcataa
    10741 gccttagaat acccttttat cattaaatca tcaaaataaa ccttatcaac taactcttta
    10801 tgtttaaata aaatattatt cgtcgaatca gctaagtcac taattacttt catttcatta
    10861 tttctaagtt tgttcttatt ataatacctc ttcttatctt ggtacattct ctcatcagca
    10921 actttaatta gcttatgtat atcaatatta tcgtcactcc aaatactgcc cactgctaca
    10981 ctatatatca tctcatcctt aaattcttca cttaaccaac tcactaattc ttcaaatagt
    11041 tgttttgata tatcttcaca taatacaaca aactcatctc ctccaatacg gtaaacatta
    11101 taagaatgaa agtatttttt tattattaca catgctgaca caatagcaga gtcgccatta
    11161 gcatgtccaa agttatcatt aatatctttt aacccattta tatctacaaa tacaactcct
    11221 atggatttaa cttttccttt ttgaaaatta tctatatact taatatattt atttctatta
    11281 tatgcaccag tcaagaagtc atagtagctc atataattta atttattttc tacttttctt
    11341 tttttcatct cagttaataa aaaataagat agggatgtca aaagagaggt atctccaaca
    11401 gctttatgtg gattatcaac tccaataaac cctactactt tatcatcttg ttttagtgaa
    11461 gatgtcatta aactttcaat tttttgaggt tttaaaattt catattctat tggctgttct
    11521 tcttttatat tttctatatc atcaattatt acaaaacctt tttgttcgaa taataaaaac
    11581 caattcttta attcattaat atcaagattt gttagtgcct gtttttgttc atcaacacct
    11641 tcattgcacc attcatatgt attagttact ttttttctat cttctgatac ttcaaaaaca
    11701 tatgctctat cagctttatg aaatttacca atattggtta atacaagatt tacagcatca
    11761 gaaaaattag attctgttat aagatgttta atacatccaa ctaataactc ctttatctct
    11821 aatttttctg ctattgactt acttatatct tctttttctg taatatcaag agctatttct
    11881 aatcgtgcat gtttgccctc ccatttaatt aacttgtcct ttaatataaa atgtctattt
    11941 gttcgagtat tcgtattttc ccatatgtaa tattcatctt cttttaaaat agagtttgta
    12001 caaaattcgc agggagaatc tttcccctgt aatgctttat aacattttaa atgggatata
    12061 tcattaagtc ccattgcctt tttaccaatt tcattaatat ataaaagttc atatgtatct
    12121 aaagaagaaa catatacaat ttcatccaac tcatctatta aatttattac atccatttat
    12181 atatatctcc ttttattcat tttccagatt gaatttttaa agcttttaaa attttgctat
    12241 atatttggca atgatattat acttctttat gttttaaaat agtaccttaa tgaggttcta
    12301 ttttttagta aatagaatta ttattgtgtc aatcgtacaa tagagttttg taatacctaa
    12361 tttaatatat ttataattaa ttatctcatt atgtgtttat aattaattct catataaatg
    12421 acaaatctcc acctcaatta agtattccaa tcatatatga agataatact tcattcattt
    12481 aaaaatataa aactattata tattaaaatt tcttcaataa taaattatct agattgttac
    12541 tttgatatat tatataatat cacaaaggct gatataaaaa gacaaaaagg gcaatttttt
    12601 tatatcaaaa aaaaatgtta aattgatatt atccatatat aaattgatat tatccatata
    12661 gatgctatat ttaacaattc tacttacttc ccttacactt attagcatat agttattaag
    12721 agtttgttgc aaaacaacac ttagcacact ttaaaaagtg tggtctaata agtaatcaac
    12781 gaagaagaca taataaagca taaaatatga tatacttttc cacgccatca aaactgagga
    12841 ttttattatt aatatatgct aaaatatgct taataaatta aattttaatg ggagaatagt
    12901 tatgaaaata tttagtttct tgttgtttgt gataggaata tgtttatgta ttgctggatt
    12961 tataggacat tacccagtat ttgttggtac aacattgagt tttcttgcaa ttgcaatgat
    13021 agctgtaaga caagtcaaaa ctaagaaaaa aatgaaatag gcaaatccta actttacaag
    13081 ttaatattac ataagtaatt agtctaaaat tggatacttt ttctattaca gaaatacatc
    13141 atccactttg tattttctta aaaaaataaa atagctatgt aaattcaaga ttagatagat
    13201 taactctcta tccatttcat tgtaaaatat acatagctat ttgtattcga tttaaaatac
    13261 ttagattttc ttacataaca aataatttct atctgattat tactcatatt catttagtaa
    13321 tcactcagca actaatcatt tagtatctat tcatccgcca tacggtaacc taccccaacc
    13381 tcagtcaaaa tatattctgg ctgagcagga ttcttttcaa ttttccttct tatacttgcc
    13441 ataaaaactc taagcgactg attttcactt tcatagtaat ttccccaaac tttatctatt
    13501 ataaacttat gggttaagac tcttcctgaa tacttagaca tcaactcaat aatcttatat
    13561 tcgattggag ttaaatgtat ttcttcacca ttaattgaca caatatgatt ttcataatct
    13621 atctttaggt ttttaacttc aaaagacttt ggagcatcat tatttatatt atcctgttga
    13681 gctttatttc taagagccac acgtactcta gccaaaagct ctgttacact aaaaggttta
    13741 gttaaataat cgtctgctcc tccatctaaa gcttccacct tatccctctc atgctctctc
    13801 gctgaaacaa caattatttt attagtcttt gcacatgccc taactcgtcc tattacctca
    13861 atcccatcaa tatctggtag tcctaaatcc aaaattatca aatctgggtc aagagaatgt
    13921 ataagtgata tagctgttcc tccattatct gtctctacac acctataatt ttgagtttca
    13981 agagatactt ttataaattt acaaattggc ttatcatctt ctacaattag aactaatggc
    14041 tttatttcca cttgtctttc ccctcctcat catacatagg tatgctaaat ctaaatgtag
    14101 ctcctccaga aggattatta aaggcgacaa tttctccacc atgagcttct actatagatt
    14161 tacatatctc caatccaaga ccaatacctc ttctttcaag atttctagac ttattcttag
    14221 tataaaacct attaaaaata ttcccgatat cttcatttgg tattcctttt ccattgtctg
    14281 caacttcaaa tagtacttga tttgactctt tttttacagt tagttctatc ttagaatttt
    14341 taggtgtatg ccttatagca ttatcaatta gatttactaa cacttgttct attaataata
    14401 catccacatg aacgattatt atctcatccg gaatatttgt ttttatgtct ctactattgg
    14461 caaacttttt gactcttaat atagattcag ctattatttc atcaacaacc tctggtcgtt
    14521 tttcaatatc caattttcct tcatctattc tggtcatact aagtatattc tcaacagaat
    14581 gagttagcca actcgtatct tcatatatat ttttcaataa ttctactcta gtttctttat
    14641 ctatcacatc atcattttca agtattgttg aagatgaacc caatatactt gtaagtggag
    14701 ttcttaaatc atgagaaatt gacctaagca agtttcctct taacctctct ctctctgcct
    14761 caagatttgc ttttttattt ttctcaaata aattttctct atcaattgcc aacgcaacct
    14821 gtgttgaaac tgcttctaat agtatctttt cattttctgt aataatatct atcttaaaac
    14881 acgcaacacc tataacacca agaacatttg attcttgacc ttttataggg aaataatatg
    14941 cactgctgtt tttacaatat tttgtcccaa ttccaactgg gttacctgtc ctaaaagctt
    15001 cttttatagc ttccttttct aatactgaat ggaatatatt ctcacttcca tcattgttac
    15061 aaatataaat acttggctta cctagattat tattctcatc tgcaatagtc actattacag
    15121 ttctatttaa tatatttact aaattagacc cacaaaattc aataatttga tttttatttt
    15181 ttgctttaag caacgttttg ttattctcat agagcaatct tatcattttt tctctcttat
    15241 gagaaagtct cacttctctt tttatcctag aagttaaagt acttgttata attgctgcca
    15301 ttagcataat acaaaaggtc ataggataat cttttctata agctaaaaaa gtatataatg
    15361 gatgcgtaaa gaaaaaatta aatgatagca ctcctattac tgaagaaagt attccaaaaa
    15421 aatatccata ggttatactt gtagcaaata gtacacctaa tatgtatact agtataatat
    15481 tagattcatt aaaacctacc ttttcaaaaa ctactgatat tccagtagca attgtcataa
    15541 ccaatatagt ttttatgaag tccttaataa ttatcttttt actgagatag ccatcttcat
    15601 cataatcata ctcttttaag tcttcatgtt gtagtcgttc ctttttcatt tactacaatt
    15661 cctccttatt gttactgttt aaattggctc tattttatat aatacaattt tatcataata
    15721 aattcaatca atacatttaa ttaatgtact taaattacta aaaggtgctg tcttaaaatg
    15781 aaaataaatc tctatttcaa aacagcacct atatatttaa attactaatt tagtttttac
    15841 atacttaaat caatagtttt attcaatttc ataaattata atacttcaat tataaaacat
    15901 ttctatccaa caagcataaa tataaagtgg gcacatatac ctgcacataa accacctata
    15961 gtatgcgaaa gtatcgcttt accagccaat ggtcttgcat ctaaagcatc catcatacct
    16021 atgtgtgtac ttaaatatcc actccaacac atacccattg ctgtgaatac tgctatatca
    16081 ttaggagtta tagcgcctga ttttataaac tctggtacta aagatattgc tgctccaaca
    16141 gctcctaatg cagttacagg gaatgctatt gcctctggtg atgtgaatcc aaataatggt
    16201 tctattatga agctaatctt atcaccaata gcaggtaata attttatacc ttcatatgca
    16261 gctcctgtgt aaacagcttg acctgtagca gggtctgtag atggtccaaa agttaataac
    16321 ataactaatg tacaaactac taaaactcct ggtattatag ccatacccat ttcaacacct
    16381 aacttaccac cttcaagtat agcatccaat gttctttgga atacattacc atctcttatt
    16441 tctctaaact cttcaagttt tgcaccttta tcatttattt gcttttcagt atcattttta
    16501 gggtcataat tataatactt tttagtaaaa gtcaacataa ttctaacact aataatacta
    16561 cctattattg ccgcaacatt acctattata gctggtagta catattcttt accttgagct
    16621 atcataaaag ttgttacaat aagtcccata ccaaaggctg ttcctaaatt acataaagca
    16681 ggtacttgat acttcttaaa atattgtgta aatgttttgt ctttagcaaa tggtataata
    16741 gctggattat cagataaata tgttgcaact actcctgcta tactagcacc aggtaagccc
    16801 catataggtc tcataagacc cttaaatatc ttattaacta aagatattac tccaaactct
    16861 gaaagcaatg cactaagtgc acctgcaaga actgccatag ccattattaa aaatactgtg
    16921 tctaataaaa gcgcatgtgc tgtactcatt attactttaa acatcattcc tgcacccatg
    16981 atgcttccta catatccaaa tcctaccgcc aatagtacaa taaatacgaa ggtttccata
    17041 cttactgcct tgactcttct cttatccgac agcttttcca tcttgaaatc ttcccccttt
    17101 taattttaaa ttaaggttcc taacattggt acaaattttt tggtacaaac tgagttctaa
    17161 aacttacact cgtaatgcaa gttgtcagtt ttttgaaata aaaaaaaatt acgtttatag
    17221 aataagaata tcctctttaa tttggatact cttattctat tttatgttat tatattatca
    17281 tccttttgtt taaaagtcaa ttttttctat ttttgttgtt taattttatt tatactcttt
    17341 ttatattttt cattttcttt tatctttgta agtactccat ataagttgac ttttctaaat
    17401 acagtagtta taaataccaa tcctaatgca attgaacttg cacacgataa tgtactcacc
    17461 ccatattcta cagcttttat ataattattg gtcaaaacag aatacatagt attatatatt
    17521 ccataacctg gtactaatat tattaaacag caaacactta atgtagttgc tggagtcata
    17581 taaattcttg cacataactc acaatatatc gcaaaacaaa ctgtagctat aaaaaaacat
    17641 aagttttctg ttactcccat atttaaaaga aatttatacg aaaaccaagc tatacttcca
    17701 cctattcctg ctagtattaa gttttttcct ttcatattaa atagcactcc aaagcttaag
    17761 gcagtaaaaa aagctgctat tacttctata aacaaatgca cttatatccc ccctaacttg
    17821 aagtacaatc caagtaccaa gaacattcct actgctatag atacacctac aaaaaatact
    17881 tctgctaatt ttgcaagacc agaaatcaac tgtccatcta ataaatctct taatgcatta
    17941 gtcaaagcaa gcccgggaac taagagcatt attgctcctg ctattaaatg gtctaacgtc
    18001 tttatgaatc cgagctttaa aattaaaatt gaacaagaag ctataataac tgctccaatt
    18061 gcatttacaa aaaagtcatt aagggaagat ttacttaaat acataataac aaacttagtc
    18121 agaatcccaa cagtaaatgc agctataaat tcttccacat ttcctccaaa taatatcgaa
    18181 aaagttgctg ctgcaatacc tgcaaaaaat attgttatta aatccgagta atagttatct
    18241 tcacttattt catctaaaat tttctcacat aattcaatat ctaaattatt tatacttatt
    18301 gctcttgata atgagttaac ttcatgaacc aagtttaggt ctactcttct tgagcttatt
    18361 cttttaattg ctgaatgtaa tttcccatct acaaatacag atgccattac agctgttgga
    18421 gttgcaaata catctacgtg atctattcca aaagattgac atattctagc tatcgtttct
    18481 tcaactctat aggtttctcc tccactttgc aacatagctt tacctgcatt tgaggaaaag
    18541 tttaaaattc tatctatatc cacaaaacat atctcccatt cttttatagt attattcata
    18601 ttttaataca agatattatt tatttaaact attttaaata attcatatcc aatatttaca
    18661 ttttatgaaa aaacttgttt tttatgcttg tcaaaatcaa attttaagct tgtttacacc
    18721 ataaaatggc tgaattaata tttgacaaac actttcaacc atttatataa ccttctaaat
    18781 tgtataactt tttactacaa ataaaattat atctctttta attctttctc ttgagtattt
    18841 agcttatagt aacttcatat ttatatatgt acaatataaa acattatttt tatgatacaa
    18901 aatataattt gtaaatgtat atatgtatta actgtgtata tataaattat tcttaacctt
    18961 atcagttttt tcatatatct tcatctatac cgaccatata ttaataaatg atattacata
    19021 gacttaagta cattaaaaaa cttaaattta gttatttaac aacataatac tctaatttaa
    19081 tctataaaaa tccataccta atataatgca actcttattt taacaccatc tattacacaa
    19141 aacaacatat taaaaagtaa aatacaaaat atccactata aaccttattt taatactgaa
    19201 tatatattat aatatattta atgtagctta aatatagttt aaacataaag aaaggaaacg
    19261 gtatatgcta agaaaagata aagttctatt atctctacat aaattatgtg aaaatatgac
    19321 tttaaaagac cttcaatcag ataaaacagg attcactaca atagaaattg ctaaccattc
    19381 atctcttgat agaagtaata ccagtaaaga attaaataac ctatacaatg aaaaaaaagt
    19441 tctgaaaata tctggtaagc caattttatt tctacatgct agtattatag aaaatttaat
    19501 tggccgtact ttgaacagtg atgaattttc tataaataat tgtaatgagc tacttaaatc
    19561 aagtaaaaat gactcagaag atattttttc aacattactt ggacatgatt ctagtcttaa
    19621 actacctata gaaaaagcta aatctgctat actctatcct ccaaaaggtc ttaatacgtt
    19681 actaatagga cctactggtg ttggaaaaag tacatttgct gaaacaatgt acaaatatgc
    19741 tgtagaaagt aaaatctttt cttctgaaag caaattcgta gtatttaact gtgctgaata
    19801 tgcagaaaat gctaacttat tattaagtaa tttatttggt tatgtcaaag gttcttttac
    19861 tggtgctaat aaggataaat tcggcatagt tgcacaggct gatggaggca tattattctt
    19921 agatgaaata cacagattac caccagaagg tcaagagatg ctttttcttt tgatggacaa
    19981 aggcatatac agacgattag gagaatctga cattgtgcat aaagctaatg tctttattgt
    20041 gtgtgccaca acagaagata tacattcttc tctgcttggg acttttttaa gaagaatccc
    20101 tgttacaatc aacctacctg ctttacagga taggtcttta aaagaaagat tatctcttat
    20161 taaatacttc tttattatag aatcaaaata caccaatgca actataaaag ttcacaaaga
    20221 tgtaattaaa tcattactcc tttatgattg ttttggtaat ataggtcagc ttaaatctga
    20281 catacaactt atgagtgcaa gagcattctt aaattacaaa actggactta aggataatat
    20341 agaaatagat ttatccattg ttcctgatta catctatatt ggtcttttaa aattgaatga
    20401 aaatcgtagt aatctaaata aattatcaga acttgattat atgctttttt atgaatttaa
    20461 tggtaataac ttagaagttg aatatacaaa agaactatct aaatacaata tagatacatc
    20521 aaacaatgga tttaaatact ctacagagat tccttatctg gaaaatgata taaggagtat
    20581 gtttataaat tacatggaaa agtactctac aaaattactt tcgatatctt cagtaactca
    20641 ttctgattat acaagtaatg agatttttaa agtaatcaat ccaaagattt actatgctgt
    20701 tgaacattct ttaaaagagg ctgaaaaaat atcgagaaac aaatacacaa aacaaactta
    20761 tattgctctt tcaatgcata taagtgcact tatagaaaat ataaatcaag acacatataa
    20821 tcctaagtac aatttatata atgataaaat tttcttagat aaagatttaa atatagctaa
    20881 aatagtttta agtataattg aaaatgactt acaaacatct ttacctaaag atgaagtaaa
    20941 atttatatcc atgtttctaa atagcatgta tcttgaacca aacaatcaat ctgaaagtat
    21001 aggagtcata atacttgctc atggaaattc aacagcaagc agtatgtgtg atgtagcaaa
    21061 ttcattgctt ggtacaaacc attgtaatgc aattgacatg cctcttgatg taaaagtaag
    21121 taccatactt gataaaacta tagagttggt aaaagaatgt gacgaaggta agggtgtact
    21181 tcttttaaca gatatgggct ctcttatagc ttttggagaa cttatttcag aaaaaacaaa
    21241 aatcaaaact cgctcaattg aaatggtatc tactccaata gttttagaag cagtaagaaa
    21301 aagtacacta ccagaaatga ctttggatga attagctaat tccttaagct ctttaaatcc
    21361 atatattgga cgagcagcaa tcgattcaac agaaataaac tatcctgaaa agtcaagaga
    21421 gtatgtaata ataactactt gtataacagg atatggttca gctatgaaag tagcagactt
    21481 tataaattct tcacttaaaa atattagtaa atacaatatt aatttagttc ctcataatat
    21541 agaaagtttt aaaatgtata agaataaatt tagtaatact aaaattctgg cagttgttgg
    21601 aagtgtagat tttaatgtag ccaacacccc ttttatacac atagaggaac tactaaatgg
    21661 atatggccta gatatgctaa acaaaataat agaaggtaca ttcaatgcca atagtattac
    21721 aaatataaaa gaaacaaatc tatcatacaa cagtttaata ataaacttta tgacccaaaa
    21781 cttagagctt ttggactctg ttaaattatt caactatgtc aattcttcct tatttacaat
    21841 aatagaatta atagatgaaa acttaaagag caaatttaag ctaggatata tactacattg
    21901 ctcttttatg atagaaagat gttttaaaaa tacaactttt ccatataata acattactga
    21961 attaattagt aaaaatcatg aactatatag tttaatacgt gaagccttta agccaacaga
    22021 agcttatttt aatattttga taccagacga agaaattgct tatataatag acatgattaa
    22081 tgagtatcta aataaataaa atttatagca cttattttgt gcatattaat taatatatga
    22141 aatggaggac gagattttga aaggaaaaat aaaacagtta acaatacttg cattaatttt
    22201 tatatttata actcctgtat ttgcatttgc agatactcca ccagtaccaa attcttcaag
    22261 agcagcacta cttatagacc aggaaactaa aagaatatta tttgaaaaaa acattgatga
    22321 aaaaatgcca ttagcgagtt taagtaaaat gatgaccttt ttattggcaa tagaagcagt
    22381 tgataaaaat caagttaaag agactgatat ggtgaaaata gacaagtcta cagcttcagt
    22441 aggaggttct acttgtaaac ttaaagatgg tgatgaaata tctctaggag agcttatgca
    22501 gggtctaatg ctagtatctg gaaatgatgc tgctatagcc atagctaaac atattggtaa
    22561 aactgaaaag aattttgtaa atatgatgaa caagaaagca gaagaaatag gaatgattga
    22621 tacgtattat tttaatccaa atgggcttcc tatatatact gacccagaac ataaagaacc
    22681 tcctattgaa aatatgtcaa ctgctcacga tatagttaca cttggaaagt atatgtacga
    22741 ccattatgaa aatcaagtta caagaataac cactatgcaa gtatataatg atactaaaaa
    22801 ggattttaca cattataaca caaatcctct gcttgtttca gtacctggtg ttgatggaat
    22861 aaagacagga tatacagata atgctggata ttgccttgca ttttctatga tggtacctaa
    22921 agatgctaaa aacgaaagaa atcatagatt gataggtgtt gtacttggtg atggtaacaa
    22981 gaaaaataga atttcttctt ccgctacttt attgaaatat ggtaaagata atttccattc
    23041 taaaaagata gcacataagg gtgatattat agagactcct tgtgttgatg gtattgatga
    23101 ttttaagata acagttaagg ttgataaaga tttgtatggt gttgtttcag ataacgagaa
    23161 tatcaatcct aaggtagtgt ttaaaaatat gaattatcct atccataagg gagatattgt
    23221 tggtgttgca aagtattata atgactctgg taaatttgtt ggaagtgttg atgtaaaaag
    23281 tgaaagtaat ataggatgta ttcctttgaa ggataagatt aagattaagg ttgctaagat
    23341 aaataaaaaa cttgagatta aaaattctgt ttgttttaaa gcatagtaaa gcatattatt
    23401 aaaagggtat gttaaattta taaagactcc actttgtgga gtctttttgt tttttacaaa
    23461 aaattaaaat agtggcaaca attgaggatg tgagggagag ttgccactat tttgtatagg
    23521 gtattatatt atgtttttaa gctagtttta ctatcttcta tgtttatata ataactcttg
    23581 tgtgtgaatt taattgataa ttcatatgaa aattatgtga agttttgatt tatttgtaat
    23641 atattctact actattataa tttttctact ggatatacta atcatttgtt taacattatc
    23701 tgagattgat ttgcaaactt ttatataact aaattagtta tataacttat agattccatt
    23761 aaatacccta ataatcatat atgtacatac aaagtcatgc ttatgcaaaa tctgcagttt
    23821 caactaactt attatataaa ccatctttat gtagaagttc agcatcattt ccagattcta
    23881 ttactctacc tttatctaat acatatatat tatcagcact cttaattgtt gaaagtctat
    23941 gagctattat aataactatc ttatcttgta tgtactcttt caagttgttc aatatctctt
    24001 tttgtgaaat attatctaga gctgaagttg cttcgtccag aataagtacc tttttattac
    24061 ttactaaagc tctagctatt gatatacgtt gtttttgacc tcctgatatt ttgacacctt
    24121 tttctcctac tacttcgtcc aatcccttat ctagattttt tataaaatca tctaaacaag
    24181 taacttctaa tatctcatct aattctttat cacttatttt attatttaat actatattat
    24241 tttttattgt gtcatcaaat acaaattgat cttgagttac tatatcaata ttatttctta
    24301 gtgattttaa attaatatcc tttatattaa caccatctat taatatatca ccttcattta
    24361 tatcccaaag tcggtatatt agatttgtta ttgttgattt gccacatcca cttccaccaa
    24421 caattcctgt tacttcccct ttctcaaatt gtaaatttat atcatttaaa acaaggttta
    24481 aatcctcacc atatctaaaa gatacatttt taaaatctat tttcttaatt tcactgttat
    24541 ctattctata tccattatta tcaactttaa tatctatctt ttcatctatt actgaaaata
    24601 ctctattgat agacactttt gattgtgcta ttctagtatt cgcccttact atagctatac
    24661 atggtccaat taacattcct gtatattgtt gaaatgctat taactccccc atcgtcatct
    24721 tattatttat tattttatat cccccaattc catatattaa tattgttatc aatcctgtta
    24781 gtatttgaga tattgctata ttactactca taatgatgtt caaattcaaa tcttttttta
    24841 tcaaatctct ctctctcttt aaatacttat taaagaaatt cttttttgaa tttaatataa
    24901 caatatccat aatattagat acgtactctt gaatcaaatt tgataaactg cctgaatcac
    24961 ttcttatttc agaaattttc ttagatataa gttttgtcat tttattttga gaaaatgtta
    25021 atatcaactg taaaaataaa actactaaaa ataaatcaaa ctgcaaatta attaagaaaa
    25081 ttaacgatat tatagctgta aacacattta caataatatc aaatataatc tctgctccaa
    25141 agttttctat cataaatata tcactttcca taatggataa aatattacct gttttcttac
    25201 ttgaataata tctaccagaa agttttgata tatggttaag caactttact tttagattta
    25261 tagtaacttt attttttatt gaagtatata aatatgataa tataacatca aatgtagctg
    25321 ataatatcct tataaaaata tatatcaata ttaaatttat aagcagaaaa atatttttat
    25381 ttcctattcc atcatctatt atacatctaa ttagttgagg tattacaata tttacgccag
    25441 caattataaa aaccattata aatgatacta tcaacttagt cttattctta tatactatta
    25501 tatttagtat tctaaataaa ttattattaa tagttttttt catctatttt tccatctttt
    25561 atagttataa ttctatcagc tgtctttgca atattatcat tatgagttat cataactagt
    25621 gtttgtttgt actctttaac acaccattca agcatattca taacttcatt tgtagtctta
    25681 ctatctaagt tgccagtagg ttcatctgca aatattactg acggtctatt ggctaaagct
    25741 ctagctattg caactctttg ttgttgacct cctgatagtt cattcggata tttctttatt
    25801 tgtttttcaa tccccaactt attaattaat ctcataacat attctttatc ttcttttttc
    25861 ccatcaagca acacaggaag tactatatta tcatatacat ttataactgg tattaaattg
    25921 taactttgaa atatgaagcc aaattcctgt cttcttattt cagacagctt atcatcattt
    25981 aatgtatata aatctacatc atctaagtac acattcccta aagttggctt gtctaagcct
    26041 gcaacacagt gaagtagtgt acttttacca gaaccacttg cacctacaat agctgtaaat
    26101 ttatgtggct ctatatctaa atcaatacca tcaagagctc taacttcatt ctcatatttt
    26161 ccatatattt tttttaaatc ttttacctta agtattttca taacgtatct ccattcccat
    26221 ttaaaaaaca tatattttta aattaaattt tcgtaaataa gatctactgc catatctaaa
    26281 ttctctaatt gatataagta tacttctttg tagtcaatac taatattaaa ctctttattt
    26341 aaaatagtta aaaaattata tgcattataa tttccaatac atgtaaaatt gttaaataaa
    26401 gaatattcac ttacaaattc aaagtctatt tttattttag aaaagtttct atttatcaca
    26461 tttattattt tccttgctat atccaatctt atcaaattag atttataact tggagtgttc
    26521 aagttttcta tttttaaatc ttctttactt ttgctttttt gaataagtat ttcttccaat
    26581 tcattaaact taatatatgg attgtttttt aatatatttg caacaatgcc agttgccact
    26641 gcacaagcct tactattttt accaaaatga gttactttat ctttaaattt aataaaatta
    26701 tcttttgaat ttgcatacat ttgaatctta ttttctggtt cgtatatata ttgattattt
    26761 ttatatatat tttcattacc tactacacca ataacacttt caaatatagt aggaatactt
    26821 tctttatctt catatttatt atgttttgaa caaataataa atctaccttg actatttaaa
    26881 atattacaaa ccttttctaa ttctttttca tacatactat taatagatgc agctgaaatg
    26941 tttattatct gtatatccga catagtcaac ttgctcagtg tactaagaag atttaaagaa
    27001 cttgtttttc cagaatcatt aaatatatta ataggataaa tttgggtatt tttacttata
    27061 tttaatatgg ttttcgatac aaaagttcca tgtccattta tgtcatttat ttccttcccc
    27121 cccaaatctt tcaattgaaa atttgaatca taaacataat ttccattaat atcatcatca
    27181 tttacatcta atcctgtgtc taagactgct attcttactt tagtcaatta ataatcacct
    27241 ctaaaataaa ttaccttgaa tataaaacta atccttacca taatataggt tccaagatgt
    27301 ttttcatttt tttacaattt gcatcaaaca tttttttgtt attttttaaa gtatatattt
    27361 tcgatggaca agttgtacaa aataaattta ctttacattc tttacaactc tcaatattta
    27421 ctggttttaa tttatcaaat atattaaata tatccatttc tctattaaga atcctctcta
    27481 atatgttttc attaaattct aatatattga atatctttaa atccttatac tctaagtttg
    27541 gacacggata tacatctcct ttatgatcta tacttatctg attaacacct gctttacaca
    27601 tatttgaaca taaactactt tcatccacat aatcatcttt gcaaatgtaa tcaatatcaa
    27661 gtttatcatt aagatatttg ctatagttct cattacctct accaatattc ataaaatttc
    27721 ttattatagg cgttgtacct aaatcttcat ttaatttatt gaatttctct atgtctttct
    27781 cattattctt tcctaccacc atagacaaac ctacgttctc gaattttttt agttttataa
    27841 gtctaatcac atttaatact ttacagaata ctcctttacc tcttacttca ctacaactta
    27901 attcatcata accatctaaa ctaatttcta ttgcatataa accattaatt atatcatcaa
    27961 tctgtttttc tttaattaaa gttgcatttg tagacagaat tattttacct ttaaattttt
    28021 cttttatata atccaacagc tctaagaaat catttctcat caatggctct ccacctgtaa
    28081 tggttaatat ccttggattt aatttaacta tattatctat tacttttctt acttgagatg
    28141 tatctaaata atcgttatta tctattttag aatctacaca gcaataatca caacttagat
    28201 tacatctatt agttggagaa aatgaaattt tgtttattct ctctagtcta aattcactta
    28261 gaatagaatc acttagaagt cctatatgct ctaacttatc tataactcgt tcataatatt
    28321 ttttatcttc attttcttgg aatacatcat acaaattacc aagttgtaat gcattatcta
    28381 ctgaatactt tagaacttca taacattcta ttggaatttt aacccatctt ccatttactt
    28441 tattactaag aataacttga ttattattta ttattttttc acatatacaa tctaaaaaat
    28501 atttgtttga gctattcatt tattttattt ccttcctata tatttaaatt agaaatttca
    28561 ttaattttct tttataccac ttactatact aagtttattt atcattttat tagaaaaata
    28621 aactgcaatg acacaaacaa aaacagatat agatccaaat attagaattt catatattgg
    28681 aatttcaaat ttaatagagt tatttatacc atatacctgt tgattaagtt tgttagtttc
    28741 agaaactatt ttataataat tgaaactaga tataattcca gctacaatca tacttaatac
    28801 cccatatatc atattttctt ttattaacat tctttttaca ttttttttgg acatccctat
    28861 tgctctaaat gtacatatct cactcaacct cacaattata tttgatctaa ctataaaaat
    28921 aatgtttata gatgatatta ataaaactcc aaatacacaa atcattgcta atttatatga
    28981 ggatttatta taatggtctc caaaatgatt acgtacatat cttccctcta tatctgaaaa
    29041 tccacttttt tctattatat tatttatttc ttttattact tttttatctg tttctttttt
    29101 tatcttcaca aaaactttat tataatcact tatccctgtt aattctttta aatccttttc
    29161 attaaatata atttgaattc cacctgattg agattctcca tcttgctctg atatatagct
    29221 atttttcatt attccagcga ttcttacttt tgtatttata tatttatact ctccatcttt
    29281 atatacagga atttttatat ctattaagtc tcctatttta ggtgatttta taatctgagt
    29341 attatttgac aatttaattc tagaataaaa attatttacc aataaaacat ttttataatc
    29401 cctgtctgta taactataaa cattttcgcc tttatctata tatttatcta tattatttaa
    29461 tagctcttta ttgtaacctc gaattaaaac tgtagactca ttattattat ttatttcagt
    29521 tctttttagc tcatctaaat aatcttcttc taagtcagca tttcttagat atccttttaa
    29581 ataaatattg ggttcaacat ctgttacatc ttcaatagct tttatttcat ttaataaaga
    29641 attatcatat ttagaaaatg tataatttgc atttattggt gaatatccca aataaatatc
    29701 aaaattgcca tatgatttac ttgttatatt agctgaatct gactcttttc catatatgaa
    29761 ttttgtagaa gttagtctgc ctataaataa aaccccacat agtgatatcg taattattat
    29821 tattattgat gtaaccttat tcctaaatat atttttaaaa gctatctcat ttataattcc
    29881 aacaactttt ttatgtgatt ttaacaacaa aagcctagga atataattta acttatctgt
    29941 cttttttata gcatcaatta tagataaatt tccagcttta tatattggta ctacagaggc
    30001 taatataact gctataattg acatgatgat agattcaatt atagagtttg tatttatagt
    30061 taattctgca cttttatcat atactatcat gagacctaag taagaaaaaa ctatacctcc
    30121 aagtaaacca attactatac ctacagataa aactacaata ctctgaataa aaaatacctg
    30181 tctaatattt ctcttgctag ctccaacagc tctaagtaaa ccaatttgct tggtcatatc
    30241 tagtattatt atgttaaaca tattgtatat tactaatgtt gcacataata aagggagtaa
    30301 gctttgcttt attgaataag ttgttttttt tgaaatattt ttcatataca tagacatact
    30361 tacttctgta tttggataaa attgattact tgttaactta tattttctcc ctagattcac
    30421 tactttttga gaatctaaat cttttgtatt caattttaat gtacccatat gagttattaa
    30481 ttcatatgga acaatatctt tgccattgtt tgaatatgta aaagctctta ccttatattt
    30541 atttaaattt tcatagtatt catcagattt acttaaaata ccaactattt taaattgctt
    30601 atctttacta taaatagaat tttcattatt tttatttata tgctcattaa caatctgaaa
    30661 atcaatagtt tgatttaatt tgacatctaa ttccattttg tctaaaactt tttgttctat
    30721 tactaattca ttagaagttc taggctctct acctttaact aacttatatc tagtagaatc
    30781 taaaaaatct ttattgtaag agcataaatt tagagatgct ccattatctt tacttataat
    30841 ttctccaaat ttaagtacat cattgaattc ttttatatct tcttcaccat taagttcttt
    30901 tactatatca ctatttatat cttcataaaa agcatgataa tctcccgagt ttttgtatgc
    30961 atgatttata tctgattgtc cttgagattc attaataaca cttaatgaaa aaactagcat
    31021 aacagcaatc cctatactaa gtattaatga taaagttttt cctttttgtc tctttaaata
    31081 tgacaccgca agtttaatat ttatcataat cagaatcctc cttattcata tttacaagaa
    31141 aaactctata acctaaaata gtaggttata gagcactatt cattaaatac taactaactc
    31201 gttgtgctag ttaaatttaa ttattaaaaa tactagagtt gagaaaatca catttcattt
    31261 gtaaaaaact acatctagta ctttcaacat atttaataga ctgattagta ttttttaata
    31321 agctactgtt ccttttggag ttgatcctgc acaatccacc atacagtcta tttgtgaaat
    31381 tattccatgc ttatcataat accatttaca tggatctgct tgcacctcaa catcttgaag
    31441 ttctattttt tcttcgattt tttttatatg tatcataata catatccccc tttacttttg
    31501 ttttatattt attataacta gttaaactag attataaact acatagtttt tttgtcgttt
    31561 ccacataaac tctttctaat ccacaataaa ttggtactgc actttggaat ttacctgtta
    31621 cctttttatt gataagttta catctggttg acatacaata atcaagtcta gtgcatccat
    31681 cacactcttc attcttagat atataaattt ttataaggtt cttaattttt ttatcatcta
    31741 atccatcata tatatttcct agtaaaatat ctttatctcc tacacatact gtacatggat
    31801 atacatctcc tctagtatct attgcataac tatttatccc tccaaaacaa tctccttttt
    31861 tcttatttat aaattgttta tctaaaatag atatatctat ctcaggataa tcctttttaa
    31921 tattcataat tttactaatt tgttcattta atattttaat atgagaatta tcccaatttt
    31981 tatccataaa atctgaaatt ggtgcgatat ttttaaaccc ttgttttgct atatcatata
    32041 cactctcata aagatactta acagtatttg agttatatgt cattcttgcc ctaacatata
    32101 tacctttatc tataagtctt tttccatttt ccattacttt ttcataagta cctactccgt
    32161 tagcatctat tctatttata tcatgtatat tcttttttcc atcaatactt atcgatatgt
    32221 tttttacatt ctttgctata aactctatta tttcatcatt tataatagtt ccatttgtag
    32281 ttatatcaaa taatatcttt ttgtcactca atctatctac taaatcccta tgtatatatt
    32341 taatcaaatc aaaatttata aatggttctc ctccatgtaa aacaattgtt gtataatcac
    32401 tattactttc taattcttta ttacaaataa aatctattgt tttatcagca gtttcataac
    32461 tcatattttc ttttttttta tcattacctt cataacaata tgtacatctc aaattgcagt
    32521 cttcagttac aaatatagta aatttcaatt aactttttca tctccccata cagctgtatt
    32581 taaattgtgt ttcatcatac tacaccatct atccaattcc aattcattat ccttaactga
    32641 atctaatatc gctgggcaat gccaacaaaa aatatttaca tcacaatctt tacatttttc
    32701 aaagttatat ggataaatac tttctaattt aatcaaagac tttagatctc ttgttttatt
    32761 ttcttttata acttttacaa attcattgtc aaatatattt cccattttat agtcatcctt
    32821 tatcagtgaa ggacaaggat atacatctcc atcataattt ataaatattt gagagtttcc
    32881 tgcattacat gcacaacatc ccattttttt atttttttta tctttacaca tttttaattc
    32941 attatctaaa atatacggaa ttgtaattgg aagaactgta tcttcaatta aatagctttc
    33001 tttattttct aggcctcttc ctgttggaat aaaatatctt tcaacaaatt ctgttccaag
    33061 ctttttattt aaatctttaa attgtttatt taaatgagaa tttttttgtc caaataccat
    33121 agacagcttt atattactga atccattgtc ttttagcaga ttaacagagc ttattacttt
    33181 attaaataca ccttttcctc gtgtttcact acaagtattt tcatctactc catcaatact
    33241 aatatctatt ttttcaaaat tagttataat aaaatcaaca ttatgttcat ctattaaagt
    33301 tccatttgtg gataatatta atttggtatc aggtaatttt tgttttatat atttaattat
    33361 ttcaaaaaaa tcttctctta tcaatggttc tccaccagtt ataattatat gaggagtatt
    33421 taaaactgat attatatcta cgatattttt taaatcatat gtactaagta aatctttctt
    33481 attagaagaa gattcaacac aacaatgttt acaaaataaa ttgcatctat ttgtcaaaca
    33541 aaaataaatt gcaacaccat tgcttaacat atcaaagttt aaattgttac ttttaaaaat
    33601 ttgatttttg ttcataatat ctataagatt aataatatat tttttgtcac tttcatcatc
    33661 aaaataattt acaaaatcat aaatttttat tttattttct tgtcctaaaa gaaaatactt
    33721 atatatttct tcagacaatt taatatattt tctaaatttc ttattataaa taattactag
    33781 ttgatttttt ctataaataa ttaaatcttc tacattaaaa atcatttctt cagaatctat
    33841 cacaactaag tcctcctcaa attagtaaaa tatttttctt taatatttat tactaatatc
    33901 aactttacta tctaattagt tatttaattg ttgtttttat gttcctagtt ataaagttta
    33961 tcaaatttac attttatttt tttatactat atagaacttt tggtcaataa tgttaccata
    34021 ctaaggtcgc atttgcagat aaaaataact ctatttttct aaatttattt aagatatatc
    34081 atgcaaataa tataactata aaacctatca acattttaaa ttcaaacaaa tataaatcac
    34141 attttttgtt ctattatttt attgagtact aaaaaggatg ttatcttatt agcatagcat
    34201 tcaaccattt ttatcacctc caaatatcct atgccttaaa gatagcatct tctattttat
    34261 ctttcaatac tactgctcca actgggcaat ttagagcccc aactagaatt agttcctagt
    34321 taatggtata taaatagtaa ttgtaaactt gtttttatct gagtatattt ccacatttcc
    34381 attatatttt tctactgaac tttttacact acttattcct attccatgta aaaaggaatc
    34441 tttcttactt gtaataacct tattattttt taatacaact tcatttatct ttgtattttc
    34501 acattttatt acaaataacc tatttataac agttcctctt aatttaatct ttttttgtat
    34561 acttgtgtcc ttaatcttaa tacaagcttc tattgcatta tctattatat ttgaaaatat
    34621 actacatata tctggcatct ctataaaatt acattctaaa aaattaatat ctactagaaa
    34681 atatatatta ttcatatcac aaatagattt tttatcactt aaaataacat ctagaatcat
    34741 attctgagta ttaaatatag tattacattc ttttatttgc ttatttatat ctttaatata
    34801 cttatctgca aactcatttt tcccataaac attctgaata caaatgatat gattattcat
    34861 atcatgatat agttttctta ttttcaactg atattcctgt aaatttaaat aatatttata
    34921 ttgcatattc attctttttt ttgtaatttc atattctatc tttaaactat tatcttttat
    34981 tattcttcct attatgctta ctaatgaaag atttgatagt aaaaatacag ttgatattgt
    35041 aagtattatt aaactctctt tagaatcgat aatcttatct ttaaaaataa attcaaatat
    35101 tactattaca ccaataatgt ttgctattaa tggaatagat aaatatatac aatccctctt
    35161 gtttattttt gtttttaatc tgataaactt aagcaatggt attaatacta ttagtaatga
    35221 tttagatatc attattaact ctaacttcaa caaattatcc tctaataaat cattcatatt
    35281 ttttatagaa ttaagtgtca ttactatact taatccaata ctatcaaatc caattaataa
    35341 catccaatat agcaaactta taaatacact tttccattta tccactacat aatttatttt
    35401 ata
//
LOCUS       DAEQCW010000033        34999 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.033, whole genome shotgun sequence.
ACCESSION   DAEQCW010000033 DAEQCW010000000
VERSION     DAEQCW010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 34999)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34999)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34999
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.033"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(210..866)
                     /locus_tag="KRO40_001597"
     CDS             complement(210..866)
                     /locus_tag="KRO40_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2092418.1"
                     /translation="MELQDTIFKRQSVRKFKNQDVSDEDILKMIKAAGAAPSGKNIQN
                     WHFVVIKRRDLMEKIADVITKKQQEILVEMDKVSVDKANRFRKFVKNFTLFYLKAPVL
                     VLVFTKVYNPSGYYELELIDAPKETIDKLFIRNPGMQSLGAAIENFTLSAIELGYGSC
                     WLTSQNYAADEIEAVLEAETGFEKGEYFLGAMLALGVPEDNLKSPSKKPVEEICTFIK
                     "
     gene            complement(921..1550)
                     /locus_tag="KRO40_001598"
     CDS             complement(921..1550)
                     /locus_tag="KRO40_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH2092419.1"
                     /translation="MVDSIIFDLDGTLWDSTEEVCKVWQDVLSEHKEIELSVTKDLFR
                     SLMGLSFEEIANRLFPNLSEEERMNLLNECSLKECDYLSENGAKLFDDIEDTLKLLSK
                     KYKLFIVSNCQVGYIESFLKAHKLEQYFIDFECPGNTGLHKGENNKLIIERNKLINPI
                     YVGDTQGDANSAKFVGIPFIYAKYGFGNVDVYDYFIDSFKDLLEHDILK"
     gene            complement(1681..2322)
                     /locus_tag="KRO40_001599"
     CDS             complement(1681..2322)
                     /locus_tag="KRO40_001599"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HBH2092420.1"
                     /translation="MKICIVLNGEIEDYEVTRDIIIKECYDCIICADGGANHTYKMEI
                     MPDYILGDLDSVEEEKINFYKNKGVKFEKFPSKKDETDTELCLFLAKTLKANHIDFFG
                     ALGGRIDHTLANIKLLYYLKEDGIYSRILSDKEEMYIVENEEISLYGNPGDTISVIAI
                     NGDAKGVTLTGLEYPLDNYYMKYSVPIGISNVMLSNSCKIKVEQGCVLVVRNL"
     gene            complement(2331..3002)
                     /locus_tag="KRO40_001600"
     CDS             complement(2331..3002)
                     /locus_tag="KRO40_001600"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBH2092421.1"
                     /translation="MIKLAPSILSADFAKLLEDVRKVESAGCEYLHIDVMDGHFVPNI
                     TLGPLVVKSLKKENINMVFDAHLMIENPDQYIEEFVKAGCDIITVHQEACVHLHRTIQ
                     NIKSHGIKAGVVLNPATPVDTIKHVLPDLDMVLLMSVNPGFGGQSFIPCVLDKIKELK
                     AIIDSQGLNIDIEVDGGISPKNVAEVVQAGANVIVAGSAIFGSDDIQETVNLFRKNAS
                     LEELV"
     gene            complement(3007..3891)
                     /gene="rsgA"
                     /locus_tag="KRO40_001601"
     CDS             complement(3007..3891)
                     /gene="rsgA"
                     /locus_tag="KRO40_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBH2092422.1"
                     /translation="MLEGKIIKGISGFYYVDTYNGIYECKARGIFRKQKITPLVGDRV
                     KISIVDENEKKGILEEIDSRDTELIRPPIANVDKALIVFAIKNPKPNLSLLDRFIVLA
                     EKENLETVIILTKADLDDNDTLETVKNIYELSGYKVIPVSNITKLNIDKVKEELKENV
                     VVFAGPSGVGKSSLLNEIDENFKLQTGVVSDKIKRGKHTTRHAELLKLEFGGMVADTP
                     GFSSLALEDIEEVELKDYFIEFDKFNDCKFGSKCIHENEPNCAIKEAVTNGEISKERY
                     DSYIQLLHEIRQNNSRRY"
     gene            complement(3989..4726)
                     /locus_tag="KRO40_001602"
     CDS             complement(3989..4726)
                     /locus_tag="KRO40_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH2092423.1"
                     /translation="MKKKTVLITGGARGIGKAMSKAFAKEGYNVLVNFNKSENEAKEL
                     YTILNEKNFSVKLFKADISNREDVEDMVDYCIKEFGGLDVLVNNAGVSQDKLFTDITD
                     EDWDNMMNINLKGSFYCSQVALKYMISEKKGNIINISSIWGISGASCEVHYSITKAGI
                     IGMTKALAKEVGPSNIRVNSIAPGVINTDMLSGYNEEDIDALVEETPLMRLGTPEDIA
                     NCAIFLASDKSNFITGQVISPNGGFVI"
     gene            complement(4834..6849)
                     /gene="pknB"
                     /locus_tag="KRO40_001603"
     CDS             complement(4834..6849)
                     /gene="pknB"
                     /locus_tag="KRO40_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HBH2092424.1"
                     /translation="MGDTILGNRYEIIRKIGDGGMAFVYEAKDRLLNRTVALKVLRPE
                     FVDDDEFLTKFKREAEAVASLSHPNIVNVYDVGEDGKVHYIVMEFVDGKNLKEIIQDE
                     GILDEYTALDITKQIAMALSAAHKKGIIHRDIKPHNILISNEGRVVKVADFGIAKAVS
                     NSTMTNIGSIIGSVHYFSPEQAKGKFVTNNADLYSLGIVLYEMLIGKVPFRGDSPISI
                     ALQHINDDIDFTSEEKVRIPQSVRTTIKKLTEKSSADRYQTAEELIEDIEYIEKNIDL
                     DFIKEYDDFATKKIDEKEINKVVNPTLAKPAPEKVVKPVEVADLDDDEDYYDDFYEED
                     DDEDEEEEEIMRAKKNQRPKSTPSKRTKKKKKKQESPKSRRRLKVIAAVLILILCAQV
                     FLAYKFLFAGGFGNKSLTVPNLVNMTLEEAQSAVEKEGLYLSVKSEEYNSEVDENCII
                     SQTPEGGSTNVKKGDTINVVVSKGSSQASVPNVVGLTLSNAKQLIEENNLKVGTVKYE
                     YSSIYKEGTVLSQSPGAGSSRAQEGDEVNLYVSKGSEKSNTQTPTVPDKKPTTPENNT
                     PTEPGSNSGNSGGNSGGSNSGNSGGNSGNNGSNSGGSNSGNSGGNSGGSNSGDNGGSS
                     GGSNSGDNGGSSGGSNSGDNGDSSGGSNSGDNGGTSSGTGANIGKTE"
     gene            complement(6866..7618)
                     /locus_tag="KRO40_001604"
     CDS             complement(6866..7618)
                     /locus_tag="KRO40_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HBH2092425.1"
                     /translation="MVYSCASHIGKIRKNNEDYCEGEVIDTEHGPIGIFAIADGMGGH
                     KKGEVASKLAVENIIDFLKENLLQHDNVKIDYIDDILKQAYNNVNSIVHKKSMEDIEF
                     EGMGTTLVTAIVYNNVLYVANVGDSRCYLLTDEKFDKITIDHSVVEELMMAHVITEEE
                     ARRHPQRNRITRAIGTDDMVVVDIFKKEIKKSDIILLATDGLTGFIDDEDIRDLILDY
                     EYERTSNISEELISMANDVSGKDNVSVIVIKV"
     gene            complement(7638..8669)
                     /gene="rlmN"
                     /locus_tag="KRO40_001605"
     CDS             complement(7638..8669)
                     /gene="rlmN"
                     /locus_tag="KRO40_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HBH2092426.1"
                     /translation="MEKKKIVLKNFTEDELKEFMKTIDEKPFRGSQIFSWIYKGAKTF
                     DDMNNIPKSLRNKLEEVSCIGHIDIELKLESKVDNTKKYLFLLDDGNIIETVMMDYDS
                     RVTVCVSNQVGCRMGCNFCASTMDGLIRNLEPWEILDQVIKIQEDTGKRVSNLVLMGS
                     GEPLDNFENTKQFLKIINEKNGLNIGYRHITLSTCGIVPKMYELADLEIAINLALSLH
                     SPYDEERRKIMPVANAYSIEEILNACRYYIKKTNRRVTFEYSLIKGVNDSEKEAKALA
                     KLLKGMLCHVNLIPINKVEEREYEKPDKAFIYKFRDSLEKNNIPATVRMSMGSDISGA
                     CGQLRRKYK"
     gene            complement(8677..10002)
                     /gene="rsmB"
                     /locus_tag="KRO40_001606"
     CDS             complement(8677..10002)
                     /gene="rsmB"
                     /locus_tag="KRO40_001606"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HBH2092427.1"
                     /translation="MDAREVGFKVLCDIEKNDNYSNIAINKHFKNLEISDMDRGLATE
                     LIYGVIENKYYLDYIINKLSKIKVKKMSTYVKIFLRMGTYQILFLDSISDYAAVNETV
                     KLSKKYDKKSSGFINAILRNEIRAKETIMDITEEDSVKYLSIKYSYNSWIIKNWIDKF
                     GQEFAEDLLEANNEKPSIYIRTNTLKISREELIEKLSEMGIVCLKVPMVEEAIKVEKM
                     KNIEKNELFKAGLFTIQDISSMIVGKVINPKEGSFVLDVCSAPGGKSTHLATLMNNTG
                     QVVARDIFEHKLKLINSTVNRLGLKNVFVERFDASEIDENSISKFDYVLADVPCSGFG
                     IIRRKPEIKYKKEEELKDITSIQKKILENASKYVKVGGTLVYSTCTIQDVENINIVTS
                     FVEENHNFEFVPIDTVNVDLDNQDKGYLKIYPNIHGIDGFFIAKLKRIR"
     gene            complement(10064..10765)
                     /locus_tag="KRO40_001607"
     CDS             complement(10064..10765)
                     /locus_tag="KRO40_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metallopeptidase"
                     /protein_id="HBH2092428.1"
                     /translation="MYPVYGGFWGFDPTMVVLIPAILLTIYAQFKVSSTTNKYLRVNT
                     RRGYTGEQTARRVLDSNGLYDVKIEMVRGHLSDHYDPRRKAVRLSEDVYYGTSITSVA
                     VAAHECGHAIQHAKGYAPLQIRSSLVPVVNFASSISWFLIFLGFIMAGPFLKIGILLF
                     SASVLFQIITLPVEFNASSRAIVQLGNLGIIDESESRQSRRVLSAAALTYVAAALVSI
                     LQLLRLLLIAQRRND"
     gene            complement(10834..11586)
                     /locus_tag="KRO40_001608"
     CDS             complement(10834..11586)
                     /locus_tag="KRO40_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF116 domain-containing protein"
                     /protein_id="HBH2092429.1"
                     /translation="MTDIKKYLTSVGILILILGILIGVVNFFIISLTQIFSLMINIII
                     ISLILIILCSTAVTYRVIKGKYVNSNIMKINFNIVSGLFPIISFIASSFGMSKSDIRR
                     IYIKLNNEYIYSNKYNFNPEDIIILIPHCIQENSCKLKVTNDIDNCKECGRCNIGELI
                     KLKEKTNVKIFVATGGTLARKIIMDNKPKAVVAVACERDLTSGIQDIKKIPVLGVFNK
                     RPNGPCVNTNVDIMDIEKAIGFLTGKNILVCN"
     gene            complement(11596..12525)
                     /locus_tag="KRO40_001609"
     CDS             complement(11596..12525)
                     /locus_tag="KRO40_001609"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HBH2092430.1"
                     /translation="MKIVFMGTPDIAVPCLQKIIDEKYEILGVVTQPDKPKGRGKKLG
                     MSPVKELAIENNIPVYQPVKARDKEFIDKIKSLNPDVIVVVAFGQILPKEILEIPKLG
                     CINVHVSLLPKYRGAAPINWVIINGEEKTGVTTMYMDEGLDTGDMILKTEVNLDENIT
                     AGELHDKMMNIGAETLKETLRLIEEGNAPREVQNHEEFSYAPIMNKSLGNIDFSKSAR
                     EIHNLVRGVNPWPSAYTTYNDVIMKVWKTKVLDEKSTKDVGTIIDVSKDGIKVSTIDN
                     VLLIEEIQMPNKKRMLVGEYIKGNTIETGLVLG"
     gene            complement(12540..12980)
                     /gene="def"
                     /locus_tag="KRO40_001610"
     CDS             complement(12540..12980)
                     /gene="def"
                     /locus_tag="KRO40_001610"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBH2092431.1"
                     /translation="MALRQIVQIGEPVLRKKSKKVEKIDEKIIQLLDDMAETMYDADG
                     VGLAAPQVGILKRVVVIDIGEELIELINPEIIETSGEQIDEEGCLSVVGEAGNVRRPN
                     YVKVRALNRNGETIELEGEELLARAFCHEIDHLDGILFVDKIEK"
     gene            complement(12998..15523)
                     /gene="priA"
                     /locus_tag="KRO40_001611"
     CDS             complement(12998..15523)
                     /gene="priA"
                     /locus_tag="KRO40_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HBH2092432.1"
                     /translation="MNNILNLSRGFIMKKYAKVIVRSNTIYTDNLFTYQIPVFLSDVI
                     KIGHRILVPFGKGNKPTEAFVFQFTDSLDEKIKIKEIIDILDENPIFRKEDLELVYWM
                     KNRYLCTYIECINLIYPKGYKLNNYKVVLLGESLSGLNDIELKEKISTLSDKNREIVE
                     KVIDSKGKIKVDKLKYIPNLNSSLYTMNKNGIIKLCWEYKNHKNEKKVCYISLSLESD
                     KIDDYIEQNKINVGSKQKEILSFLKNNENVEINDLLDLLNASKQSINSLSKKKLITLE
                     FKDYYREPKSIYKSVLKSIKLNNEQQEAVDEIKSNMFVDDKKPYLIHGVTGSGKTEVY
                     MEIIEFALNQGLDSIFLVPEIALTPQTIDRLKSRFGDLVGVFHSKLSEGEKHDVYKAV
                     KAGKVRVLIGARSALFAPFNSLGLIIIDECHESSYKSEKNPKFNAIEVARFMALKNNI
                     TLILGSATPSIEEYYRAKSGEYKLINIKSRANDKPLPNIEVVDMKDELDKGNRSIFSL
                     KLQKEIRYAIEENNQVILFLNRRGYANFVSCRKCGYVFQCENCDISLTYHKKSNTGRC
                     HYCGYEKEIPKECPECKSTYVKPFGVGTQKIEEELKYIFPDIKTLRMDKDTTSKKGAL
                     DEILNKFKDKEADVLIGTQMLSKGLDFENVTLVGILSADMILNFPDFKSFETTFQLIT
                     QVSGRAGRADKEGKVVLQTYDTEHYAIKHAIEYDYEGFYEDEIKIRKAFGYSPFNNML
                     SVVVSGEDERLVIKNIKNMHASLIYLLEKRGINDLGFILGPNPCSISKINQNYRWQIL
                     FKDENIEINLLKGIIKYICITKRDLIFDKNINVSIDINPNSVL"
     gene            complement(15762..16961)
                     /gene="coaBC"
                     /locus_tag="KRO40_001612"
     CDS             complement(15762..16961)
                     /gene="coaBC"
                     /locus_tag="KRO40_001612"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /protein_id="HBH2092433.1"
                     /translation="MLKDKTVVIGISGGIAAYKACDVVSKLKKLNANIHVIMTKSATE
                     FVKPLTFQSLSQNYVVEDMFEEPKTWEVEHISLAKKADLFLIVPASANVIGKIANGIA
                     DDMLTTTVMATKAQVLIAPAMNTNMYENPIVQKNIQTLKSFGYKFIEPESGRLACGDI
                     GTGKLANPDIIVEEVLTNLTKEQDLKGQSMIVTAGPTVESIDPVRYLTNRSSGKMGYS
                     IAREAIARGADVTLISGPTNLSIPQNLKKFVQIESAQDLYEAVVSNLSENKIVIQSAA
                     VADYKPKTYSDKKIKKKNDDLSIELSRNYDIAYEIGKIKEDKILIGFAAETNDLIEHA
                     KGKIKKKNLDFIVANDLTKEGAGFRADTNIVKIIDVEGNITEYPKMKKEEVANVILDK
                     VKALLEK"
     gene            complement(16966..17232)
                     /locus_tag="KRO40_001613"
     CDS             complement(16966..17232)
                     /locus_tag="KRO40_001613"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HBH2092434.1"
                     /translation="MLKPSINEVLEKIDNRYYLVGTVSKRARKLIDGEEPYVSNKTKE
                     KPVCVATKEVASGKITYRLLTEEEIEIEEARHHAEQHQQISEEE"
     gene            complement(17235..17852)
                     /gene="gmk"
                     /locus_tag="KRO40_001614"
     CDS             complement(17235..17852)
                     /gene="gmk"
                     /locus_tag="KRO40_001614"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HBH2092435.1"
                     /translation="MFVKKGLLLVVSGPSGAGKGTICKELLKENDTIKLSVSATTRKP
                     RTGEVDGVNYFFISKEKFEEMIEKGEFLEYAQIYDNFYGTPKAAIMECLEKGQDVLLE
                     IEMQGAKQIKEVCPEGVFIFVLPPSLKELKNRIVGRGTETEAEIEKRFSCAYEEIKMI
                     KDYDYFIFNEDVKTSAKEIEGIISSEKNKVSRYKNIIIEKFKEEL"
     gene            complement(17882..18763)
                     /locus_tag="KRO40_001615"
     CDS             complement(17882..18763)
                     /locus_tag="KRO40_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YicC family protein"
                     /protein_id="HBH2092436.1"
                     /translation="MAISMTGFGRGEYKDDNYYFLVECKTINHKYSDINIRLPRKISF
                     LEDKVRNLVKNYVKRGRVDLYIKFDLLGKEDVNLNFDEGLASQYIDILKEIKNKFDII
                     DDISVMNVAKFPDIVKIEEKEEDEDLLWSMLNQAVEDALIKLREMRSEEGKKLAEDIA
                     MRCDLLKNHIEEIEKYSSSVVEDYREKLNLRISELLDDPSIIDENRLAQEVAIYADKS
                     SITEEIVRFKSHIGQLKNTIFKDDSIGRKIDFLIQEMNRETNTIGSKSSDINITNLVV
                     EVKSELEKIREQIQNIE"
     gene            complement(18767..19597)
                     /locus_tag="KRO40_001616"
     CDS             complement(18767..19597)
                     /locus_tag="KRO40_001616"
                     /EC_number="5.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate epimerase"
                     /protein_id="HBH2092437.1"
                     /translation="MKFWKLHGIGNDFIAIDGRFDQINPSDYTALAKKVCHRRFSVGA
                     DGLLVVKDSKVADVEMVYYNSDGSRAAMCGNGLRCFCKFVYDNCIVKKESFTVDTLDG
                     IKDIKVNLTNREINSIRVNMGKGSFIAKDVPVLTNKERFVQESIKVLDRELKVTSMLM
                     GVPHTVVIVDELDVDDVCKYGKEIENNKIFPEKTNVNFVKVEDKYNIHVYTWERGCGY
                     TLGCGTGMTASAIVCNLLNMVESSVNVTSQGGTVKIDVGDFSYMTGPAVKICEGILEV
                     "
     gene            complement(19884..20918)
                     /gene="ltaE"
                     /locus_tag="KRO40_001617"
     CDS             complement(19884..20918)
                     /gene="ltaE"
                     /locus_tag="KRO40_001617"
                     /EC_number="4.1.2.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low-specificity L-threonine aldolase"
                     /protein_id="HBH2092438.1"
                     /translation="MRFIDLRSDTVTMPTDEMREAMAKAPVGDSIFRDDPTVNKLEEL
                     AAAKVGKEDAIFLPSGTFGNQLALFTHCLRGQEIIIGKGYHIVTHEVGAPAVIAGVQL
                     RTIDEDESGALNPELVEKAIRRDDIHEPQTGLICVENAYSGGTVVSLDNLREIKKIAE
                     KHNLPVHLDGARLFNAALTLGVEAKEIAKCCDSVMFCVSKGLAAPMGSILAGNKEFIA
                     KARRKQKVMGGGMRQVGIVAAAGIIAIEKMTLRLNEDHENAKYLACELNKIDGIEVNN
                     VNPDISMVFFKMSEDIIKEDVLIKEFFERNIKINKMENGEYRFVTHVDITKEDLDYVL
                     KTLKELIGVC"
     gene            21214..22989
                     /locus_tag="KRO40_001618"
     CDS             21214..22989
                     /locus_tag="KRO40_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NFACT family protein"
                     /protein_id="HBH2092439.1"
                     /translation="MALDGLVIHSIVDELSSKLTGGKIDKIHQPEDDEVIFNIRNNKE
                     NFRLVLSASASNPRVYLTSNYQKENPLKAPMFCMLLRKYIQGGNIVEISQIGFERIIK
                     ISVESLDELKEKTVKNIMIEIMGRHSNIIITHGEENKIIDSIKRVPFSISRVRQVLPG
                     HDYSLPPEQNKLNPLDDISKDLFIKNLEELEGPIFKSIYSKFLGISPIIAKEICYRAG
                     VNQNAIIKDISDEQFDSLHKVFCNLFNDINSNKYSPCIIIDKKVDKVVDFSCINLTLF
                     SDLSYINKDSMSRILEDFYRTKDIKDRINQRSSDLKKSISVKLDRLYNKLKKQEEELS
                     ESENADIYKIKGELITSYIYMVEKGMESIEVANFYDENCNDVTIELNKNLTPSENAQK
                     YFKKYNKMKHAKVEISHQISLNKEEIDYLENIILSIENCENLAELQDIKEELAKVGYI
                     KTQKKNSKKDTIPSTKPHEFVSSDGFKILVGKNNKQNDYLTLRLADNDDLWMHTKNIP
                     GSHVIIKCAGKEVPDNTVFEGAMLAAFFSKSKLSSQVPVDYTKRKNVKKPSGSKPGMV
                     IYETNSTIYVTPEEETVAKLKVKSE"
     gene            complement(23204..24856)
                     /gene="abc-f"
                     /locus_tag="KRO40_001619"
     CDS             complement(23204..24856)
                     /gene="abc-f"
                     /locus_tag="KRO40_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein"
                     /protein_id="HBH2092440.1"
                     /translation="MLLVKVENLKKYYADKLILDIDKLEILENDKIGLVGSNGQGKTT
                     LLKAILGEIEIDEGYTYLTESYSYISQSENNIETCSHSKEKSLLNAPDKFEEHLSGGE
                     KVKLKIADALSNKKNIIIADEPTSNLDKKSIGVLEDMFKRHEGALLLISHDRRFLDEL
                     CTTILELEDGKLKAYKGNYTDYLMQKDEEVKRADFEYQEYVKEKKRLEKALLYKKALS
                     DGIRKTPKRMGNSEARLHKMGGQTNKKKLDSNVKAIKSRIDKLEVKNKPKVSKEMNIK
                     IQDGMEIISKNLVEVKDMTLKLENKLLLDNVSFKIKRGKKIALLGDNGCGKSTLIKEI
                     LADKNDNIKINNKVKVGYFDQNQSLLDEEKSVLYNTKVNSSFDESFIRINLSLFGFKG
                     DDVYKKVKVLSGGEKVKIALCKIILEDNNFLVFDEPTNYLDIKSMEALEKALINTDKT
                     MLIVSHDRVFVSHICNYIIEIKDAKIREFDCNYDEYTISRNKKTPSRENQIKKENLLV
                     LENRLTTVISMLSIEKDNLKKELYESEYNELLKQINKLKNSF"
     gene            complement(25155..26366)
                     /locus_tag="KRO40_001620"
     CDS             complement(25155..26366)
                     /locus_tag="KRO40_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HBH2092441.1"
                     /translation="MKKTIMSLQHLLAMFGATVLVPILTGFNPSVAIFCAGVGTLIFH
                     FCTEGKVPAFLGSSFAFIPVILAAKEAYGGDLAYAQGGIIVAGLIYIIMSIIVKIVGV
                     NKIKLYFPAQVTGAMIVVIGLNLLPTAFSMASANFVIASITLAIAILTNKFGRGFIKQ
                     LGILIAVFSGYIICLILRLVDITTITEASLFAIPNFTVPKFSLGAIVIISPVVLAVFM
                     EHIGDMTTNGAVVGKNFIENPGLNRTLLGDGFATIVAGCLGGPANTTYGENTAVLAIT
                     KNYDPSILRRTAIFAILLACVGKFGGFLQSIPGSVMGGISIMLFSMITYVGLKTIRDS
                     SCVESKINILIIAVILLIGLGTTYLSNKGISIGIPITSTVKITGLSLAAIVGIVLNRI
                     LNNQDFKVEEE"
     gene            complement(26650..27183)
                     /gene="pyrR"
                     /locus_tag="KRO40_001621"
     CDS             complement(26650..27183)
                     /gene="pyrR"
                     /locus_tag="KRO40_001621"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001156491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HBH2092442.1"
                     /translation="MVEKAQLMDEKAIARAITRISHEIIERNKGVENLVLVGIKTRGV
                     PIANRISKKIEQIEGTKVDTGDIDITLYRDDLEKIHVEPVVKGTYLDFNVNDKTVVLV
                     DDVLYTGRTVRASLDAIIDIGRPKSIQLAVLVDRGHRELPIRADYVGKNVPTSRHEII
                     SVSLLEIDGEDSVTIKE"
     gene            complement(27543..28490)
                     /locus_tag="KRO40_001622"
     CDS             complement(27543..28490)
                     /locus_tag="KRO40_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH2092443.1"
                     /translation="MFYFLKVKVGDIMDEVKEFLVLEEEEEVRLDIYLAEQLGDMSRS
                     YIQKIIKDGKVKVNNKVEKARYLVKEEDNIVIEIPEPKVLEVLPQDIPIDIVYEDDDV
                     LIINKPQDMVVHPAPGNYENTLVNGILYHCKDKLSSINGVIRPGIVHRIDKDTSGLLM
                     IAKNNYAHNFLAEQLKEHTITREYEFICYGVVKEDKITVDKPIGRNPKDRLKMAVVKD
                     GKNAITHFEVVERFDKFTHMRARLETGRTHQIRVHALSINHPLLGDYVYGPKETKFKL
                     KGQTLHAKKLGFIHPTTKEYIEFNSELPEYFKEVIKKIK"
     gene            complement(28459..28905)
                     /gene="lspA"
                     /locus_tag="KRO40_001623"
     CDS             complement(28459..28905)
                     /gene="lspA"
                     /locus_tag="KRO40_001623"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729400.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HBH2092444.1"
                     /translation="MLYILIIILLIGLDQLSKIWVLNNLVDVSTIPIINNVFHLTYVE
                     NRGAAFGLLQNNQWIFIIVALLATVFGLYYLNTRKVHIFGRLGIILIISGALGNLIDR
                     VRLGFVVDYFDFRIIWEYVFNIADVFVVVGTVFLCIYVLFFESKSR"
     gene            complement(29215..29994)
                     /locus_tag="KRO40_001624"
     CDS             complement(29215..29994)
                     /locus_tag="KRO40_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2092445.1"
                     /translation="MKKIIWGICICLLSIVGVYTYNHNTHNQDSSKEAYSLNDNIKDD
                     YEDVIIKKGNEDEKILALTFDDGPDEDFTPQVLDILKKNDVKATFFVVGEKVEYNKEL
                     LKRQYDEGHEIGNHTFTHINVAKNSYSSVEKEITDTQNIIKSVIGVEPKIFRPPYRAM
                     SKSVCDIIVSKGMNIILWSNLDPRDWSNPGVDAIINTILTKVQNGNIILLHDYNTKRN
                     DKSQTIQALEVVIPKLKERGYKFVTVSELIQHLDKNKQVQK"
     gene            complement(30049..30531)
                     /locus_tag="KRO40_001625"
     CDS             complement(30049..30531)
                     /locus_tag="KRO40_001625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBH2092446.1"
                     /translation="MDTKKYKDKLLKERENLTNLVEDMKDNTLFGDTTKHTSEKYSSG
                     ELSSYDNHIGDMGTDLYMQNMQNSLINHEEGRLYQIDLALSKIENGTYGICDLCHNQI
                     DLERLDILPDTSLCNDCAKKENNLLGDAMQNPDVEDSNFYSEDLTNLTDLNKNGILRD
                     "
     gene            complement(30797..32218)
                     /locus_tag="KRO40_001626"
     CDS             complement(30797..32218)
                     /locus_tag="KRO40_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBH2092447.1"
                     /translation="MVSFLGSIVVLIVGYFVYGTFVEKVFGTNDKNQTPAIACRDGVD
                     YVPMKWKRIFLIQFLNIAGLGPIFGAIQGALFGPSAFLWIVFGTIFAGGVHDFASGYL
                     SMKNKGTSASELVGLYLGNGAKIAMRIFSVILLVLVGVVFVTGPAGLLKTLTGVNAQI
                     WVGVIILYYIMATVLPIDKLIGKIYPLFGAALLIMAVGVAGGLIIKGYNIPNINLQNM
                     NPNGTPLFPYLFITIACGAISGFHATQSPLMARCVEKESEARPVFYGSMVAEGIIALV
                     WAAAAMSYFHGIPQLNVIFNDGGAATVVNTVSVGLMGPIGGALAILGVVACPITSGDT
                     AFRSARLTIADAMNYNQDAVKNRFLIALPLFAVGVALTFIDFNIIWRYFSWANQTLAM
                     IMLWTGSAYLVKANKNHYITTLPALFMTVVTFSYIMQAKEGFRLPVNISNGIGVIVAI
                     ILGLLFFKKAKHIKEQNNHKLAS"
     gene            complement(32364..33134)
                     /locus_tag="KRO40_001627"
     CDS             complement(32364..33134)
                     /locus_tag="KRO40_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001295458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092448.1"
                     /translation="MRAIIVEDEFPARKELRYFIENKSGIEVVSEFTNGIEVLDFIQE
                     NKIDVIFLDINIPHLDGMLLAKTLNQFKSRPKIVFITAYESYAVDAFSLDVFDYILKP
                     YSEERIISMLNKLEKSEMSDIELFNVNSNLYKYKKEAVNQEIEEITHKISLWKGDKLV
                     VIDIDDIYYCEANERQTFIYTEKEKFILKEGISEVENLINDKTFFRTHRSYIVNLTKV
                     KEIIPWFNNTYILKLKNSDYEVTVSRSKVKEFRLLMHI"
     gene            complement(33139..34341)
                     /locus_tag="KRO40_001628"
     CDS             complement(33139..34341)
                     /locus_tag="KRO40_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH2092449.1"
                     /translation="MKTSILIALIEKTSLIVVLFLLITKLKIFKQIFQKEEYSFNDLV
                     CIALVFTFLAIFGTYSGINYMGSIVNTRIISIVSGGILFGPMVGITAGVFSGIHRYFM
                     DIGGITSVPCLLSSILAGVLSGFLYKRIPKQHRVMYGILVGMISESFTILLIYLISYP
                     HSLAIQIIGGIYLPLIVGQIGIGFVISIVEGIEKDKKDIEARNKAEIKALQRQINPHF
                     LFNSLNTIASFIRFSPDKARELIINLSTYLRYNLEYSDNLIDINKEIEQVKSFVEIEK
                     ARFGELLTVSYDIEDVNIKIPSLIIQPLVENAIIHGILESGRAGVVKISIKKLPYSLE
                     NTVRISIEDNGIGISEEIINNVYQDNMPENKIGLYNVHLRLKLMYGRGLNIRRIDNGT
                     LIVFYVKE"
BASE COUNT        11170 a         6394 c         3504 g        13931 t
ORIGIN      
        1 gatattacat atacttttct aaagattttc taaagattta aatatattta aaattaatat
       61 acaaaaaaag tagttcttat tgtattaatt aaatcaatga tttgaaatat aaaattaata
      121 tcaataaaac ctacttttta attttttaaa tatttatttt taatttattt tgtttttaat
      181 ttacttcgat tttaaaatgt ccttgacttt tattttataa atgtacatat ttcttctact
      241 ggttttttag atggactctt caaattgtcc tctggcactc caagagctaa cattgcacct
      301 aaaaaatact ctcccttttc aaaaccagtt tctgcttcta aaacagcttc tatctcatct
      361 gctgcatagt tttgacttgt caaccaacaa gaaccatatc caagttcaat tgctgatagt
      421 gtaaagtttt caattgcagc acctagactc tgcatacctg gatttcttat aaataattta
      481 tctatagtct ccttaggtgc atctataagc tctaattcat aatatcctga tggattatat
      541 acctttgtaa aaactaatac taaaactgga gcttttaagt aaaatagtgt aaaattttta
      601 acaaattttc taaatctatt agccttatcc actgatactt tatccatttc tacaagtatt
      661 tcttgttgct ttttagttat cacatctgct atcttttcca ttaaatcacg gcgttttata
      721 acaacaaaat gccagttttg aatattcttg cctgatggtg ctgcacctgc tgcttttatc
      781 atttttaaaa tatcttcatc tgatacatct tgatttttaa actttcttac actttgtctt
      841 ttaaaaatag tatcttgtaa ttccattttt aaatcccccc ataacttttt tattatttta
      901 atataatttt taaactcatc ttattttaat atatcatgtt ctaacaaatc tttaaatgaa
      961 tctataaaat aatcatatac atctacattc ccaaacccat atttggcata tataaaaggt
     1021 atacctacaa acttagcact atttgcatca ccttgcgtat caccaacata gattggattt
     1081 attaatttat ttctttcaat tataagttta ttattttctc ctttatgcaa accagtatta
     1141 ccaggacatt caaaatctat aaaatactgt tctagtttat gtgcttttaa aaaagattct
     1201 atatatccaa cttgacaatt acttactata aataatttat attttttaga tagtaattta
     1261 agagtatctt ctatatcatc aaataattta gctccatttt cagataaata gtcacattct
     1321 ttcaaagaac attcattcaa taaattcatt ctttcttctt cacttaaatt tggaaataaa
     1381 cgatttgcta tttcctcaaa agaaagcccc ataagacttc taaataaatc ttttgtgaca
     1441 cttaattcta tttccttatg ctcacttaaa acatcctgcc agactttgca tacttcttca
     1501 gttgaatccc acaatgttcc atctaaatca aaaataatac tatctaccac aaaaaatccc
     1561 ccttatgtca aagtttatta tatatttata attatatact aaaaagcaga tacaatcata
     1621 aatatatttt acttgattgt atctgctcta caatataaaa ccaattgtca aaatcaaatt
     1681 ttataaattt ctaactacaa gtacacagcc ttgctctact ttaatcttac aagaattact
     1741 caacataaca tttgatattc caataggtac agagtatttc atataataat tatcgagagg
     1801 gtattctaag ccagtaagtg ttacaccctt agcatcacca tttatagcta ttacagaaat
     1861 agtgtcccct gggtttccat acaatgaaat ttcctcattt tcaactatat acatctcttc
     1921 tttatcagaa agtatcctag aatatatacc atcttctttt aaataatata atagctttat
     1981 atttgcaaga gtgtggtcaa tccttccccc taaagcacca aaaaaatcaa tatgatttgc
     2041 tttaagtgtc ttagctaaaa aaagacaaag ctctgtatca gtctcatctt ttttagatgg
     2101 aaatttttca aatttaacac ctttattttt atagaagttt atcttttctt cttctactga
     2161 atctaaatct cctaatatat aatctggcat tatttccatt ttataagtgt gatttgcccc
     2221 tccatctgca catattatgc agtcataaca ttccttaatt ataatatctc ttgtaacttc
     2281 gtaatcttca atttcgccat ttaaaacaat acagattttc attattaaat ttaaactaat
     2341 tcttcaagag aagcattctt tctaaataaa ttaactgttt cttgaatgtc atcacttcca
     2401 aatattgcag aacctgctac tattacatta gctcctgctt gtacaacttc ggctacgttt
     2461 ttagggctta taccaccatc aacttctata tcaatgttta atccttgact atctataata
     2521 gcttttaact ctttaatctt atctaaaaca caaggaataa atgattgtcc tccaaatcca
     2581 gggttaacag acattaataa taccatatct aaatcaggta gtacatgttt aatcgtatct
     2641 actggtgtag ctggattaag tactacacca gcttttattc catgtgattt tatattttgt
     2701 atagttctat gtagatgaac acaagcctcc tggtgaacag ttattatatc acatcctgct
     2761 tttacaaatt cttcaatata ctggtctgga ttttctatca taagatgagc atcaaatacc
     2821 atatttatat tttctttctt taaacttttg actacaagtg gtcctaatgt aatgtttggt
     2881 acaaagtgtc catccattac atcgatatga agatattcac atcctgcact ttctactttt
     2941 cttacatctt ctaataattt tgcaaaatct gctgataata ttgatggtgc taatttaatc
     3001 atgtttctaa tacctcctac tattattttg tcttatttca tgtagcagct gtatataact
     3061 atcatatctt tctttagata tttctccatt tgtaacagct tcttttatag cacaattagg
     3121 ttcattttca tgaatacact ttgaaccaaa cttacaatca ttaaatttat caaattctat
     3181 aaaataatct ttaagttcaa cttcctctat atcttcaagg gcaagggaac taaaacctgg
     3241 tgtatctgca accattccac caaattctaa ttttaaaagt tcagcgtgac gagtagtatg
     3301 ttttcccctt tttattttat cacttacaac tcctgtttga agtttaaaat tttcatctat
     3361 ttcatttaat aagcttgatt ttccaactcc agatggtcct gcaaacacta ctacattttc
     3421 ttttaattct tcttttactt tatctatatt taacttagta atattgctta caggaatgac
     3481 tttatagcca ctaagttcat atatattttt aacagtttct aatgtatcat tatcatctaa
     3541 atctgctttt gtaaggatta ttacagtttc taaattttct ttttctgcca aaactataaa
     3601 tctatctaaa agagataagt ttggtttagg attttttatt gcgaatacta ttaatgcttt
     3661 atctacattt gcaataggag gtcttataag ttctgtatct ctactgtcga tttcttctaa
     3721 gatacccttt ttttcatttt catcaacaat gcttattttg actctatcac caaccaaagg
     3781 tgttattttc tgctttctaa atatccctct agccttacat tcataaatac cattataagt
     3841 atctacataa taaaatccac taatcccctt tataattttt ccttctagca tcaaatgcct
     3901 ccctttataa aatttatata aacacatact gtttatgagt agtatatcgt gttattcttt
     3961 cctattttta tataatacca catttttttt aaataacaaa tcctccgttt ggactaatta
     4021 cctgaccagt gataaaattt gatttgtctg atgccaagaa aatagcacaa tttgctatat
     4081 cttctggagt tcctagcctc attagagggg tttcttccac aagagcgtct atatcttcct
     4141 cattatatcc agataacatg tcagtattaa tgacacctgg agctatgcta tttactctaa
     4201 tatttgatgg tcctacttct ttagctaatg cctttgtcat acctattatg cctgcttttg
     4261 ttatagaata atgcacttca caagacgcac ctgatatacc ccagattgaa gatatattaa
     4321 ttatatttcc ttttttttct gatatcatgt attttaaagc aacttgtgaa caataaaagc
     4381 ttccttttaa attaatattc atcatattat cccaatcttc atcagttata tctgtaaaca
     4441 acttatcttg acttacacca gcattgttta caagtacatc caatcctcca aattctttta
     4501 tacaataatc taccatatcc tctacatctt ctctatttga aatatcagcc ttaaaaagtt
     4561 ttacagaaaa atttttttca tttaatatag tgtacaactc tttagcttca ttttctgact
     4621 tattaaaatt tactaataca ttgtaacctt cttttgcaaa agctttagac atagctttac
     4681 caatccctct agctcctcct gtaattaaaa ctgttttctt cttcataaat acttttctcc
     4741 ttatattata accaattcag tattttatac aaaacaaact gccctttaaa gaaaatattt
     4801 tctataaaag gacagctctt attttattaa tatttattct gttttaccaa tgtttgcgcc
     4861 agttcctgat gaagttcctc cattatctcc tgagtttgag cctcctgaac tatctccatt
     4921 gtctcctgag tttgaacctc ctgaacttcc tccattgtct cctgagtttg agcctcctga
     4981 acttcctcca ttatctcctg agtttgagcc tcctgagttt ccaccactat ttcctgagtt
     5041 tgaacctcct gagttacttc cattattgcc tgagtttcca ccactatttc ctgaatttga
     5101 gcctcctgaa tttccaccac tgtttcctga gtttgaacca ggttctgttg gtgtattatt
     5161 ctctggtgtt gttggttttt tatctggtac tgttggagtc tgtgtatttg atttttctga
     5221 acctttgctt acatataggt ttacctcatc accttcctga gctcttgatg agccagcacc
     5281 cggactctga cttaaaactg taccttcttt atatattgag ctgtattcat acttaacagt
     5341 tcccactttt aagttatttt cttcaataag ttgttttgca ttactcaaag taagtcccac
     5401 tacattagga acagatgcct gacttgaacc tttacttacg acaacattta tagtatcacc
     5461 ctttttgaca tttgtacttc caccttcagg tgtctgtgat attatacaat tttcatcaac
     5521 ttcactatta tactcttcac tttttacact caggtataat ccttcttttt caacagcact
     5581 ttgagcttct tctaatgtca tatttacaag attaggaaca gtcaaagatt tattgccaaa
     5641 ccctccagca aataaaaact tatatgctaa gaatacttga gcacacaata tcagtatcaa
     5701 aacagccgca attactttta atcttcttct agattttggg ctttcctgtt ttttcttctt
     5761 tttcttagtt ctcttacttg gagtactctt aggtctctga ttctttttag ctctcattat
     5821 ctcttcctct tcttcatctt catcatcatc ttcttcataa aaatcatcat agtaatcttc
     5881 atcatcatcc aaatcagcta cttcaacagg cttaaccact ttttcaggag ctggttttgc
     5941 aagtgttgga tttacaactt tattaatttc tttttcatca attttcttag ttgcaaaatc
     6001 atcatattct tttataaaat ctaaatcaat atttttttct atatactcta tatcttctat
     6061 caattcttca gcagtttgat atctatctgc actagatttt tctgtaagct tttttattgt
     6121 agttcttaca ctttgaggaa tcctaacttt ttcttctgat gtaaagtcta tatcatcatt
     6181 aatgtgttga agtgctatag aaattggact atctccccta aatggaactt ttcctatcaa
     6241 catttcatat aaaactatac ctagagaata caggtcagca ttattagtta caaatttacc
     6301 tttagcttgc tctggtgaaa aataatgcac tgaacctatt atactaccaa tattagtcat
     6361 tgttgaattt gaaacagctt tggctatacc aaaatcagcc acttttacta ctcttccttc
     6421 atttgatatg agaatattat gaggttttat atctctatgt ataatcccct ttttgtgcgc
     6481 tgcactaagt gccatagcta tttgttttgt tatatctaat gcagtatatt catctaatat
     6541 accttcatct tgtataatct cttttagatt cttcccatct acaaactcca ttacaatgta
     6601 gtgaactttt ccatcttcac caacatcata aacatttact atatttggat gtgaaagact
     6661 tgctactgct tctgcctctc ttttaaactt tgttagaaat tcatcatcat ctacaaattc
     6721 aggtctaagt actttaagtg caacagtcct gtttaataat ctgtctttag cctcatatac
     6781 aaaggccatt cctccatcac caatcttcct gatgatttca tatcgatttc ctaaaattgt
     6841 atctcccaca atatcaccgt cctaattata cttttatcac tataaccgaa acattatctt
     6901 taccagaaac atcattggcc atacttatca attcttcact tatattacta gttctctcat
     6961 attcataatc taatattaaa tctcttatat cttcatcatc aataaaccca gttaatccat
     7021 ctgtcgcaag aagtattata tcactttttt tgatttcttt cttaaaaata tctacaacaa
     7081 ccatatcatc tgttccaatt gctctagtta ttctattcct ctgtggatgt cttcttgcct
     7141 cttcttctgt aatgacatgg gccatcataa gttcttcaac cacggaatgg tctatagtta
     7201 ttttatcaaa tttttcatct gttaacaaat aacatctgct atctccaaca tttgccacat
     7261 ataagacatt attatacact atagccgtaa ctaatgtagt tcccattcct tcaaattcta
     7321 tatcttccat agattttttg tgcacaattg agtttacatt attataagcc tgttttaata
     7381 tatcatctat atagtctatt tttacattat catgttgtaa taagttttcc tttagaaaat
     7441 caattatatt ttctactgct aatttactgg cgacttcacc ttttttatgt ccacccattc
     7501 catcagctat ggcaaatatt cctattggac catgttctgt atctataact tctccctcac
     7561 aatagtcttc attgtttttt cttatttttc ctatatggga ggcacaacta taaaccatac
     7621 gacttcctcc ttacaaatta cttgtatttt cttctcaatt gcccacaagc tccactaata
     7681 tcagaaccca tagacatcct aactgtggca ggtatattgt tcttctccaa actatcccta
     7741 aatttataaa taaatgcttt atctggtttt tcgtattctc tttcttcaac tttatttatt
     7801 ggaattaaat ttacatgaca tagcatacct tttaggagct tagctaatgc ctttgcttct
     7861 ttttctgagt catttactcc ttttataaga gaatattcaa atgtaaccct tctatttgtc
     7921 ttttttatat aatatctaca tgcattcaat atttcttcaa tagaataagc atttgctaca
     7981 ggcataattt ttcttcgttc ttcatcatat ggtgaatgaa gtgataaagc taaatttata
     8041 gctatttcta agtctgccaa ctcatacatt ttaggtacta ttccacaagt tgaaagagtt
     8101 atatgtctat accctatatt aagaccattt ttttcgttaa ttatttttaa aaattgtttt
     8161 gtattttcaa agttatcaag tggctcacca ctccccatca atacaagatt tgataccctc
     8221 ttaccagtat cttcttgaat tttaataact tggtctaaaa tttcccatgg ctctaagttt
     8281 ctaattaatc catccattgt agatgcacaa aaattacatc ccatcctaca acctacttgg
     8341 ttagaaacac agacagtaac tctactatca taatccatca tcacagtttc tattatattt
     8401 ccatcatcta ataaaaacaa atattttttt gtattatcta ccttagattc taactttaat
     8461 tctatatcta tatgccctat acatgaaacc tcttctaatt tatttctcaa actttttggt
     8521 atattgttca tatcatcaaa agtttttgca cccttatata tccaagagaa tatttgactt
     8581 cctctaaagg gcttttcatc tatagttttc ataaactctt taagttcatc ttcagtaaaa
     8641 ttttttaata ctatcttttt cttttccatt ctctcactac cttattctct ttaattttgc
     8701 tatgaaaaaa ccatctatac catgaatatt aggatatatc tttaaatatc ctttatcttg
     8761 attgtctaag tctacattta ctgtatcaat tggaacaaat tcaaagttgt gattttcttc
     8821 aacaaaagaa gtaactatat ttatattctc cacatcttga attgtacatg tactatatac
     8881 taaagttcca ccaactttga catatttaga tgcattttct aaaattttct tttgtataga
     8941 agtgatgtct tttaactctt cttctttctt atacttaatt tctggtttac gtcttattat
     9001 accaaaacca gagcaaggaa catctgctaa aacataatca aatttactta tactattttc
     9061 atcaatctca gaagcatcaa atctttctac aaacacattt ttaagcccca atctatttac
     9121 agtagagttt ataagcttta gtttatgctc aaaaatatct ctagctacta cttgaccagt
     9181 attgttcatt aaagtagcta agtgagtaga tttccctcca ggagcactac atacatccaa
     9241 aacaaatgaa ccttcttttg gattaattac tttccctact atcatagaac ttatatcttg
     9301 aattgtaaat aaaccagcct taaataattc atttttttct atatttttca ttttttcgac
     9361 tttaatagct tcttctacca taggaacttt taaacataca atacccattt cacttaattt
     9421 ttcaataagt tcttctctac ttattttaag tgtattcgtt cttatataga tactaggctt
     9481 ttcattattt gcttccaaca aatcttcagc aaattcttgt ccaaatttat ctatccagtt
     9541 ttttataatc caagagttat aggaatactt tatagataag tattttacac tatcttcctc
     9601 agttatgtcc attatagtct ctttagctct tatttcattt ctaagaatag catttatgaa
     9661 accagaagat tttttatcat atttcttaga taattttaca gtttcattaa ctgctgcata
     9721 atctgatata ctatctaaaa ataaaatctg atatgttccc attcttaaaa agattttaac
     9781 ataagttgac atttttttta cctttatttt tgaaagttta ttgattatat aatctaaata
     9841 atatttattt tctattactc cataaattaa ctctgttgca agtcctctat ccatatcact
     9901 tatttctaaa tttttaaaat gcttatttat tgcaatattt gaataattgt catttttttc
     9961 tatatcacat aatactttaa atccaacttc tcttgcatcc atataaattt ctccctttta
    10021 ttaaacataa aaaagggttg tttctaaaca acccacttta cttttagtca tttcttcttt
    10081 gagctattag taacaatcta agtaattgaa gtattgaaac caatgctgct gcaacatatg
    10141 ttaaagctgc tgctgaaagt actcttctac tttgtcttga ctcactttca tctataatcc
    10201 ctaaattccc aagttgaacg attgctctac ttgaagcatt aaattctaca ggcaatgtta
    10261 ttatttggaa taacactgaa gccgaaaaca atagtatacc aatttttaaa aatggaccag
    10321 ccataataaa tcctaaaaat attaaaaacc aagatatact tgaagcaaaa ttcactactg
    10381 gtactaaact acttcttatt tgaagaggtg cataaccttt agcatgttgt atggcatgac
    10441 cacactcatg tgcagctact gcaacagaag ttatagatgt tccataatat acatcttctg
    10501 acaaccttac agcctttctt cttgggtcat aatggtcact tagatgccct ctaaccattt
    10561 ctatctttac atcatacaaa ccatttgaat caagtactct tcttgctgtt tgctctccag
    10621 tatatcctcg acgtgtattt actcttaaat acttatttgt tgttgaactc actttaaatt
    10681 gtgcatatat agtaagtaat atagctggaa ttaatacaac cattgttggg tcaaatcccc
    10741 aaaaaccgcc atatacaggg tacataaata acactctcct aaaatatatt tttattatac
    10801 atcctcttaa tattcacttc acttaaaaac agtttaatta caaactaata tattttttcc
    10861 tgttaaaaag cctatagctt tttcaatatc cataatgtct acattagtat ttacacaagg
    10921 tccattaggt cttttgttaa atacacctaa aacaggaatt ttcttaatat cttgtattcc
    10981 agatgtcaaa tctctttcac atgcaacagc tacaacagct ttaggtttat tatccattat
    11041 aatttttcta gctagggttc ctccagtagc tacaaatatt tttacattag ttttttcctt
    11101 tagcttaatt aattctccta tgttgcatct tccacattct ttacaattat ctatatcatt
    11161 agtaactttt aatttacaac tattctcttg aatacaatga ggtattaaaa ttattatatc
    11221 ctctggatta aaattatatt tattactgta tatatattca ttatttaact ttatatatat
    11281 tcttctaata tcactttttg acataccaaa tgatgatgca atgaaagata taataggaaa
    11341 taatccactg acaatattaa aatttatttt cattatattt gagttaacat actttccttt
    11401 aattactcta taagtaactg ctgttgaaca tagtattata agtattagtg atattattat
    11461 aatatttatc atcaaggaga atatttgagt taaacttatt ataaaaaaat taacaactcc
    11521 tatcaaaatt cctaatatta aaatcaaaat cccaacactt gttaaatact tctttatatc
    11581 tgtcatactt ttcacctaac ccaatactaa accagtttct atagtattcc cttttatata
    11641 ttcaccaacc aacattctct ttttattcgg catctgaatt tcttcaatta aaagtacatt
    11701 atctatagta cttactttta tcccatcttt gcttacatca attattgtac ctacatcttt
    11761 tgtgcttttt tcatctaaca ctttagtttt ccaaactttc attatgacat cattataggt
    11821 agtataggca cttggccatg gatttactcc tctaactaaa ttgtgtattt ctctggcact
    11881 ttttgaaaaa tctatgttac ctaatgattt attcattatt ggcgcatagg aaaattcttc
    11941 atgattttgt acttctcttg gagcatttcc ttcttcaatt aatcttaatg tttcttttaa
    12001 agtttctgcg cctatattca tcattttatc atgaagttct cctgctgtta tattttcatc
    12061 aagatttact tctgtcttta gtatcatatc tccagtatct agcccttcat ccatatacat
    12121 agttgtaaca ccagtctttt cttcaccatt tattattacc caatttatag gtgccgcacc
    12181 tctatatttt ggaagtaaag aaacatgaac atttatacat ccaagtttag gaatctctaa
    12241 tatttctttt ggaagtatct gtccaaaagc tacaactact attacatctg gatttaaaga
    12301 tttaatttta tctataaatt ctttatctct agcctttact ggttgatata caggtatatt
    12361 attttcaatt gccagttctt ttactggact catacctagt tttttacctc ttccttttgg
    12421 tttatctggt tgagttacaa cacccaatat ttcatacttc tcatctatta ttttttgtaa
    12481 acatggaact gctatatcag gagttcccat aaatactatt ttcatcaaat caactcctac
    12541 tacttttcta ttttgtcaac aaacaaaatt ccatctaagt ggtctatctc atgacaaaat
    12601 gctctagcta aaagttcttc tccctctaac tctattgttt caccatttct atttaaagct
    12661 ctgaccttta cataatttgg tcttctaaca tttcccgctt ctccaacaac acttaaacat
    12721 ccttcctcat ctatttgctc cccagatgtt tctattattt caggatttat aagttctata
    12781 agctcttctc caatatctat tactactact ctttttaata ttccaacttg aggtgcagcc
    12841 agtccaacac catctgcatc atacatagtt tctgccatat catctaataa ttgtattatc
    12901 ttttcatcaa ttttttcaac cttttttgat ttttttctta atactggttc tcctatttga
    12961 actatttgtc ttaaagccat tataattcct cctaaattta taatacactg tttggattaa
    13021 tatctataga tacattgata ttcttatcaa atatcaaatc tcgttttgtt atacatatat
    13081 attttattat accctttaag agattaattt caatattttc atctttaaag agtatttgcc
    13141 atctataatt ttgatttatt tttgatattg aacatggatt tggacctaat ataaatccta
    13201 aatcatttat accccttttt tctaataaat aaatcaatga tgcatgcata ttttttatat
    13261 tttttatcac tagtctttca tcttcaccac taacaactac acttaacata ttattaaaag
    13321 gagaatatcc aaatgctttt cttattttta tctcatcttc ataaaaaccc tcataatcat
    13381 attcaatagc atgcttaata gcatagtgtt cagtgtcata agtctgaagt actacttttc
    13441 cctctttatc agctctccct gctcttccag agacttgagt tatcaattga aatgtagttt
    13501 caaaactttt aaagtctgga aaatttaata tcatgtctgc agacaaaata cctactaaag
    13561 ttacattctc aaaatccagc cctttactta acatctgtgt tccaataagt acatctgctt
    13621 ctttatcttt aaatttattt agtatctcat ctaaagcacc tttttttgaa gttgtatctt
    13681 tatccattct caaagttttt atatctggaa aaatatattt taattcctct tcaatttttt
    13741 gagttccaac tccaaatggc ttaacataag tacttttaca ttcaggacac tcttttggaa
    13801 tttctttctc atatccacaa tagtggcatc ttccagtatt gcttttctta tgataagtta
    13861 aagatatatc acaattttca cattgaaaca catatccaca ctttctacaa gatacaaaat
    13921 ttgcataacc tcttctgttt aaaaatagta ttacttgatt attttcttca atcgcataac
    13981 gtatttcttt ttgtaatttc aaactaaata tacttctatt tcctttatct aactcatctt
    14041 tcatgtctac cacttcaatg tttggaagag gcttatcatt tgctctactt tttatattta
    14101 taagtttgta ttctccagat tttgccctat aatactcttc aattgagggc gttgctgaac
    14161 ctaaaataag agttatatta ttttttaatg ccataaatct agcaacttct atagcattaa
    14221 attttggatt cttctcagac ttatatgatg actcatgaca ttcatcaatt attattaagc
    14281 ctaaggaatt aaaaggtgca aataaagctg acctagctcc aattaacact cttactttac
    14341 ctgctttgac agctttgtaa acatcatgtt tttctccttc agatagttta ctgtggaaca
    14401 ctccaaccaa atctccaaac ctactcttta gcctatctat tgtttgagga gttaatgcta
    14461 tctcaggtac taagaatata ctgtctaagc cttgatttag agcaaattct attatttcca
    14521 tgtaaacttc agtttttcca cttccagtta ctccatgaat taagtatggt tttttatcat
    14581 ctacaaacat attcgacttt atctcatcaa ctgcttcttg ttgctcattg tttaatttta
    14641 tactttttag tacggatttg taaatacttt ttggctctct ataataatcc ttaaattcta
    14701 gggttattag ctttttctta cttagagaat ttatactttg ttttgaagca tttaataaat
    14761 ccaataaatc atttatctct acattttcat tatttttaag aaaacttaat atctcttttt
    14821 gtttacttcc cacatttatt ttattttgct ctatataatc gtcaatctta tcactttcta
    14881 aactcaaaga tatataacat accttctttt catttttgtg atttttatat tcccaacata
    14941 attttataat tccattctta ttcattgtgt acaaagaact atttaagttt ggtatatatt
    15001 ttaacttatc aaccttaatt ttacctttac tatcaatcac tttctctact atttctctat
    15061 ttttatcact taaagttgat attttttcct tcaattcaat atcatttaat ccacttaaac
    15121 tttcacctaa taggactact ttataattat ttaatttgta tccctttgga tatatcaaat
    15181 ttatacattc tatataagta cacaaatatc tatttttcat ccaataaacc aactctaaat
    15241 cttcttttct aaatatcgga ttttcatcta atatatcaat aatttctttt atttttattt
    15301 tttcatctaa gctatctgta aattgaaata caaaggcttc tgttggttta ttaccttttc
    15361 caaatggtac taatattctg tgcccaattt ttattacatc agataaaaat acaggaattt
    15421 gatatgtaaa taaattatct gtatatatag tattacttct aactattacc tttgcatatt
    15481 ttttcattat aaaacctcta cttaaattta atatattgtt catattttaa tatactttac
    15541 aagatattaa aatctcagaa tttataagca atttcaagtt attaatatta actttatttt
    15601 aataattaac tattaattat attttatact ttatgacaaa ataaatgctg aaaactacaa
    15661 tttaactgac atttgcgagt ttttactcgc taaaattaaa ttgcagcttt cagccacttt
    15721 agctgtgata aaatacacaa atatcatatt taaaaaaggt cttatttctc aagcaacgct
    15781 ttaactttat ctaaaataac attggctact tcttcttttt tcatcttagg atactcagta
    15841 atatttccct ctacatctat tatttttaca atattagtat cagctctaaa accagcacct
    15901 tctttagtta aatcatttgc cacaataaaa tctaaatttt tcttttttat ttttcctttg
    15961 gcatgttcta taaggtcatt agtttcagct gcaaatccaa ttagtatctt atcttctttt
    16021 atttttccta tttcataagc aatatcataa tttctactta gttctattga taaatcatca
    16081 ttcttctttt taattttttt gtcagaataa gtttttggtt tataatctgc aactgctgca
    16141 ctttgaatta ctattttatt ttcacttaaa tttgatacta ctgcttcata caaatcttgt
    16201 gctgactcta tttgaacaaa ttttttaaga ttttgtggaa tagaaagatt tgtaggacct
    16261 gatattaatg ttacatcagc acctctagct atagcttctc ttgctataga atatcccatt
    16321 ttaccagaag acctattagt taaatatctt actgggtcta tactctctac agttggacca
    16381 gctgtaacta tcatactttg accttttaaa tcttgctctt tagtaagatt agtcaaaact
    16441 tcctctacta ttatatctgg attagctagt ttacctgttc caatatctcc acatgcaagc
    16501 cttccacttt ccggttcaat aaatttatat ccaaagctct ttaaagtttg tatatttttt
    16561 tgaacaattg gattttcata catattagta ttcatagctg gtgctataag aacctgtgct
    16621 tttgttgcca taacagtagt tgtcaacata tcgtcagcta taccatttgc aatcttgcct
    16681 ataacatttg cacttgctgg cactattaag aataaatctg ctttttttgc taatgatata
    16741 tgttcaactt cccaagtttt tggttcttca aacatatctt ctactacata attttgactc
    16801 agcgattgaa atgtaagtgg tttaacaaat tctgttgctg attttgtcat tataacatgg
    16861 atatttgcat ttagtttttt taacttactt acaacatcac aagccttata tgcagctata
    16921 ccgccactta tgccaattac aacagtttta tcttttagca tgaccttact cctcttctga
    16981 aatttgttgg tgttgctcag catgatgtct agcttcttct atctctattt cctcttctgt
    17041 caataatcta tatgttattt ttccacttgc aacttcttta gttgctacac atacaggctt
    17101 ttccttagtt ttatttgaaa catatggttc ttctccatca attaattttc ttgctctctt
    17161 tgaaacagtc cctactaaat agtatctgtt gtctattttt tctagtacct cattgataga
    17221 tggttttaac ataattataa ttcctcctta aatttctcta ttataatatt tttatatctg
    17281 ctaactttat tcttttcaga tgatattata ccttctattt ctttagcaga tgtttttaca
    17341 tcttcattaa atataaaata atcataatcc ttaatcattt taatttcttc atatgcacag
    17401 ctaaatctct tctctatttc agcttctgtt tctgtacctc ttccaacaat tctatttttt
    17461 aattctttaa gtgatggtgg tagtacaaat ataaatactc cctctgggca aacttctttt
    17521 atttgttttg ctccttgcat ttcaatctcc agtaatacat cttgtccttt ttctaaacat
    17581 tccattattg ccgcttttgg agttccataa aaattatcat aaatttgagc atactccaaa
    17641 aactcacctt tttctatcat ctcttcaaac ttttccttac ttatgaagaa ataatttact
    17701 ccatcaactt ctccagttct gggttttctt gtagtagctg atacagaaag ttttattgta
    17761 tcattttctt taagtagttc tttgcaaata gtaccttttc ctgcacctga tggtcctgat
    17821 acaactagca ataatccttt tttcacaaac atttaagcat tccccttcta atattgtatt
    17881 cttactctat attttgtatt tgttctctta ttttttccaa ttcgcttttt acttctacta
    17941 ctaaattagt tatatttata tcagatgact tcgaacctat agtgttagtt tctctattca
    18001 tctcttgtat taagaaatct atttttctac ctatagagtc gtctttaaat atagtatttt
    18061 taagttgccc tatatgactt ttaaatctaa ctatttcttc tgttatactg cttttatctg
    18121 catatattgc aacttcttgt gctaatctat tctcatctat tatacttggg tcatccagta
    18181 attcacttat tctcaaattc aatttttctc tataatcttc tacaacacta cttgaatatt
    18241 tttcaatctc ttctatatga ttttttaata aatcacatct catggcaata tcttcagcta
    18301 attttttacc ttcttcactt ctcatttctc ttaatttgat taatgcatct tcaactgctt
    18361 gattcaacat tgaccacaat aaatcttcat cttcttcctt ttcttctatt ttcacaatat
    18421 caggaaactt tgcaacattc ataacgctaa tatcatctat aatatcaaat ttatttttta
    18481 tttcttttag tatgtctata tactgagatg ctaatccctc atcaaaattt aagtttacat
    18541 cttctttgcc taataagtca aactttatgt ataaatctac tcttcctctt tttacataat
    18601 tttttactaa atttctaact ttatcctcta aaaatgaaat ttttcttgga agacgtatgt
    18661 ttatatctga atacttatga tttatcgttt tacactctac taaaaagtaa taattatcat
    18721 ccttgtattc tcctcttcca aaaccagtca tacttatagc cattaattaa acctccaaaa
    18781 taccttcaca tatttttact gctggacctg tcatataaga gaaatctcct acatctattt
    18841 taactgttcc accttgagac gttacattta cactactttc taccatatta agtaaattgc
    18901 acactattgc tgatgcagtc ataccagtac cacaacctaa agtatatcca caacctcttt
    18961 cccaagtata aacatgtata ttatacttat cttctacctt tacaaaattt acattcgttt
    19021 tttcaggaaa tattttatta ttttcaatct cttttccata tttacaaaca tcatctacat
    19081 ctaattcatc tactataact actgtatgag gaacccccat caacatagaa gtaactttaa
    19141 gctccctatc taaaaccttt atactttctt gcacaaaacg ttctttattt gtaagtacag
    19201 gaacgtcctt agctataaaa cttccttttc ccatattgac tcttatagag tttatttctc
    19261 tattagtaag atttactttt atatctttta taccatctaa tgtatctact gtaaaacttt
    19321 cttttttaac tatacaatta tcataaacaa atttacaaaa acatctaagg ccatttccac
    19381 acatagctgc tcttgaacca tcagaattat aatataccat ttctacatct gcaacttttg
    19441 aatctttcac aactaacaat ccatccgctc ctacagaaaa tcttctatgg catacttttt
    19501 ttgctaaagc agtataatca gatggattta tctggtcgaa tcttccatct attgctataa
    19561 aatcatttcc tattccatgt agtttccaaa atttcataag tatcgctcct tcgtaaatta
    19621 acacttaaac tattataaca taaaaaaatt cccataaact tataatttat gggaaaagtt
    19681 ttgtaatgac aactataatt tgaggatgtg agggagagtt gccattacaa ttagggtaat
    19741 tatattatgt ttttaagcta gttctttcta tgtttatata ttaatatttc tatatgaatt
    19801 ttatgtatgt tttatttaaa ctgtctatga attttttaat taaacatctg gtaactagct
    19861 ataatccttc tagtagatat ctattaacat acacctatta attctttaag tgtttttaaa
    19921 acatagtcta aatcttcctt agtaatatct acatgagtta caaatctata ttcaccattt
    19981 tccattttat taatttttat atttctttca aaaaattctt ttattaaaac atcctctttt
    20041 ataatatctt cactcatctt aaaaaatacc atacttatat ctggattaac attgtttact
    20101 tcaatgccat caattttatt taattcacaa gctaaatatt ttgcattttc atggtcttca
    20161 ttcaatctta aagtcatttt ttcaatggca attataccag ctgctgcaac tatacctact
    20221 tgtctcattc ctccacccat aactttttgc tttcttctag cttttgctat aaattcttta
    20281 tttccagcaa gtatagaacc cattggtgca gctaaacctt ttgacacaca gaacataaca
    20341 ctatcacaac actttgctat ttctttagct tctacaccca aagttaatgc tgcgttaaat
    20401 aatcttgctc catctaaatg tactggtaag ttatgtttct cagctatttt tttaatttct
    20461 cttaaattat caagactcac aactgttcca cctgaatatg cattttctac acatataagc
    20521 cctgtctgtg gttcatgtat gtcatctctt ctaattgcct tttcaacaag ttcaggattt
    20581 agagctccac tttcgtcttc atctatagtt ctaagctgaa ctccagctat tacagcaggt
    20641 gccccaacct catgagtcac aatgtgataa cctttaccaa taattatttc ttgccctctt
    20701 aggcaatgag taaatagagc taattgattc ccaaaagttc cacttggaag gaaaatagca
    20761 tcttcttttc caactttagc tgctgctaat tcttcaagtt tatttacagt agggtcatct
    20821 ctaaagattg aatctccaac aggagccttt gccatagctt ctctcatttc gtcagtaggc
    20881 atagtaacag tatcacttct taaatcgata aatctcattt tttcaacctt ctttcatatt
    20941 tatatactat agaaccttaa aattgatttt ttctgtaaag ttcatatact ttcatagctt
    21001 atactctaca caataattat actatattta ctttatattt aatctacttt aaattattaa
    21061 ttttaaaaat aaagtttcct ctctaataaa tataaataat tatacaattt aaatattaat
    21121 ctctattgtt taaattcccc ctagtcacaa agcgtatatt atgtgtataa ttaatttact
    21181 gactcatttt ggtcaaagaa aggggtgcta taaatggcat tagatggatt agttatacat
    21241 tcaatagtcg atgaattatc atcaaaactt acaggtggaa aaatagataa gatacatcaa
    21301 cctgaagatg atgaggtaat ttttaatata agaaataata aagaaaattt tagattggtt
    21361 ttaagtgcaa gtgcctcaaa tcctagagtt tatcttacaa gtaattatca aaaagaaaac
    21421 cctctaaaag cgcctatgtt ttgtatgtta cttagaaaat acatacaagg tggaaatata
    21481 gtagaaattt ctcaaatagg ttttgaaaga ataataaaaa taagtgttga atctttagat
    21541 gaattaaaag aaaagacagt taaaaatatt atgattgaaa ttatgggaag acatagcaac
    21601 ataataataa ctcatggtga agaaaataaa attatagatt ctataaaaag agtccctttt
    21661 agcataagta gagttcgtca agttttacct ggtcatgatt attcattgcc accagaacaa
    21721 aacaaactca accctcttga tgatatatct aaggatttgt ttattaaaaa cctagaggaa
    21781 ttggaaggac ctatctttaa gtctatatat tctaaatttc taggtataag ccctattata
    21841 gctaaagaaa tttgctacag agcaggtgta aatcaaaatg ctatcataaa ggatatatct
    21901 gatgaacaat ttgattcttt acacaaagta ttttgtaatt tattcaatga tataaattct
    21961 aacaaatact ctccttgcat tattatagat aaaaaggtgg ataaggtagt tgatttcagt
    22021 tgtataaacc ttacattatt tagcgattta tcatatataa ataaggatag tatgtctcgt
    22081 attctggaag atttctatag aactaaggat attaaagata gaattaatca acgttcatct
    22141 gatttaaaga agagtatatc tgttaagctt gatagacttt ataataaact taaaaaacaa
    22201 gaagaagaat tatcagaatc cgaaaatgca gacatttata agataaaagg agaattgatt
    22261 acttcatata tttatatggt agaaaaaggt atggaaagta ttgaagttgc taacttctat
    22321 gatgaaaatt gtaatgatgt aacaatagaa ttaaataaaa acttgacacc atctgaaaat
    22381 gctcaaaaat actttaaaaa gtataacaaa atgaaacatg ctaaagtcga gatatctcat
    22441 caaatttcct taaataagga agaaatagat tacttagaaa acataatttt aagtattgaa
    22501 aactgtgaaa atttagctga attacaagat ataaaagaag aacttgctaa ggttggatac
    22561 atcaagactc aaaagaaaaa cagtaaaaag gatactatcc catctacaaa acctcatgaa
    22621 tttgtttctt ctgatggatt taaaatattg gttggtaaaa acaataagca aaatgactat
    22681 cttacactaa gacttgctga taatgatgac ttatggatgc atacaaagaa tattcctggt
    22741 tctcatgtaa taataaagtg tgctggtaag gaagtccctg ataatactgt atttgaagga
    22801 gctatgctag cagcattctt tagtaagtca aaactttctt ctcaggtgcc tgtagactat
    22861 actaagagaa aaaatgtgaa aaaacctagt ggttctaaac caggtatggt tatttatgaa
    22921 actaacagta ctatttatgt tactcctgaa gaagaaacag tagccaagct taaggttaaa
    22981 tctgaataaa ttctgcacta aatacaaaat aaatgttaga caactacaca ttatcattct
    23041 aaataaaaat agtggccttc ttataaagta caataataag gccactttct aattagctta
    23101 cttttaattt tctaacaaaa tacttttctg ttttaataac tatacttata ttcccaacaa
    23161 atattttcag tcttcttata tagatgtaat taaaaagtta acactaaaag ctatttttta
    23221 atttattgat ttgttttagt aattcattat attctgattc atacaattct ttttttagat
    23281 tatctttttc tatagataac atagatataa cagttgtaag tctattttct aatactagaa
    23341 gattttcttt tttgatttgg ttttctctac taggagtttt tttatttctg ctaattgtat
    23401 attcgtcata attacaatca aactccctta ttttagcatc ttttatctct ataatatagt
    23461 tacaaatatg tgatacaaat actctatcat gagacactat aagcatagtt ttatcagtat
    23521 ttatcagtgc cttttccagt gcttccatag attttatatc taagtaattt gttggttcat
    23581 caaatactaa aaaattatta tcttccaata ttattttaca tagtgctatt tttacctttt
    23641 ctccaccact aagtactttt acttttttgt agacatcatc acctttaaac ccaaataggc
    23701 ttaagtttat ccttataaaa gattcatcaa atgaactatt aactttagta ttgtatagaa
    23761 cactcttttc ctcatctaat aaactttgat tttggtcaaa ataacctact tttaccttgt
    23821 tatttatttt tatattgtca tttttatcag ccaatatttc ttttatcaga gtactttttc
    23881 cacacccatt atcacctaat aatgctatct ttttacctct ttttatctta aaggaaacat
    23941 tatctaacag gagcttattt tctaacttta gagtcatatc ttttacctct actagatttt
    24001 tactaattat ctccatacca tcttgaatct taatgttcat ttctttagaa actttaggtt
    24061 tattctttac ctcaagttta tcaattctgc tttttatagc cttcacattt gagtccaact
    24121 ttttcttatt agtctgacca cccattttgt gcaacctagc ttctgaatta cccattcttt
    24181 ttggtgtttt tcttatgcca tcacttaaag cttttttata taaaagagct ttttcaagcc
    24241 tttttttctc tttaacatat tcttgatact caaaatcagc tctttttact tcttcatctt
    24301 tttgcattaa ataatcagtg taattgcctt tgtaagcttt tagttttcca tcttctagtt
    24361 ctaatatagt tgtacataac tcatccagaa aacgtctatc atgagatatt aataataatg
    24421 ctccctcatg ccttttaaac atatcttcca aaaccccaat gcttttttta tctaagtttg
    24481 aagttggctc atcagctatt atgatatttt tcttattact cagcgcatct gctattttta
    24541 acttaacctt ttcccctcct gataagtgtt cttcaaattt atctggagca tttaaaagac
    24601 tcttctcctt actatgacta catgtttcaa tattattttc actctgactt atataagaat
    24661 agctttctgt aaggtaagta tatccttcat caatttctat ttctcccaat attgctttta
    24721 ataatgttgt ttttccttga ccatttgaac caactagacc tattttgtca ttttctaata
    24781 tttcaagttt atctatatcc aaaattaatt tatctgcata atatttcttt aaattctcta
    24841 cttttactaa caacataaaa aatccctcct taacacactt aaatataagg agagattcta
    24901 taaataggca taacaaataa acgtatagac tataatctac tctccttaat ttaagcattg
    24961 caaataaagc caccaaaata ggcttttcaa aaattacaat actttaaatt ataaaaaata
    25021 gattatattc tcattgtcct agttaccttg ccctttcttt catttatttt taatcattat
    25081 atcaacatta attacaaatg tctatagaaa attaactaat tttagttatt caatatacaa
    25141 cttattcttt aaatttattc ttcttcaact ttaaagtcct gattatttaa aattctgttt
    25201 aatacaattc caacaattgc agctaaacta agaccagtta tctttactgt acttgttata
    25261 gggattccaa tagaaatacc tttattagat aaatatgtgg ttccaagacc tattaataat
    25321 ataactgcta tgattaatat atttatttta ctttctacac aagaactgtc ccttatagtt
    25381 tttaatccta cataagttat catcgaaaat agcattatac taattccacc cataactgaa
    25441 cctggtatac tttgaagaaa tccaccaaac tttcctacac atgcaagcaa tatagcaaat
    25501 attgctgtac gtctaagtat tgaagggtca tagtttttag ttatagcaag tactgctgta
    25561 ttttctccat aagttgtatt tgctggtcct cctaaacacc ctgcaactat agtcgcaaat
    25621 ccatccccaa gtaatgttct atttaatccg ggattttcta taaagttttt acctactaca
    25681 gcaccattag tagtcatatc tcctatatgt tccataaata cagctaatac aactggagat
    25741 ataatcacaa ttgctcctaa actgaactta ggaactgtaa agttaggtat tgcaaataaa
    25801 cttgcttctg taatagtagt tatatctact aatcttaata tcaaacagat tatataccca
    25861 gaaaaaactg ctattaatat tcctaattgt tttataaatc ctctaccaaa cttattggtt
    25921 aaaattgcta ttgctaaagt tatagatgct attacaaaat tggctgaagc catactaaaa
    25981 gctgttggca ataaatttaa tcctataact actatcatag ctcctgtaac ttgtgcagga
    26041 aaatataatt taattttatt tacaccaact atttttacta taatcgacat tataatataa
    26101 attaatcctg ctactattat accaccttga gcatatgcta aatctccacc atatgcctct
    26161 ttagctgcta gtataactgg tataaacgca aaacttgaac ctaaaaaggc aggtactttt
    26221 ccttctgtac aaaaatgaaa tatcaatgta ccaacaccag cacagaaaat tgcaactgac
    26281 ggattaaaac ctgtcaaaat gggaactaat actgtcgctc caaacatggc taatagatgt
    26341 tgtaaagaca ttatcgtttt tttcataaaa acctccaaaa ttattatata taaataaatc
    26401 ctctgtttaa ttaatatctt ttaattaatt atcattccct agattctatt ttttaacctc
    26461 tatatactta ttatataatt tatcattatt ttacatttta cgacatcaaa aactcaaata
    26521 aaggagaata aaaactacat taagactcac atccataaaa ttataatatt tattttgtgc
    26581 aatctatgta agctttatcc tcctccctga ctattcaatg ctaagctttt atataatact
    26641 taaaaataat tattctttga ttgtaactga atcttctcca tcaatttcta ataaactgac
    26701 agatataatt tcatgtctag aagtaggtac attttttcct acataatctg ctcttatagg
    26761 caactctcta tgccctctgt ccactagcac tgctaattgt attgatttag gtcttcctat
    26821 atctataata gcatctagtg aagctctcac agttcttcca gtgtataaaa catcatcaac
    26881 taaaactact gtcttatcat ttacattaaa atctaaataa gttcctttaa ctacaggttc
    26941 aacatgaatt ttttccaaat catctctata caaagttata tcaatatctc ctgtatctac
    27001 ttttgttcct tctatttgtt ctattttctt agaaattcta tttgcaattg gcacacctct
    27061 agtctttatt ccaactaaaa ctagattttc tacaccttta tttctttcaa ttatttcatg
    27121 acttattcta gtaattgctc ttgctattgc cttttcatcc attaattgag ctttttctac
    27181 catatcataa ttattgtcaa agatataata tatctatttg acaaatctac tcctttcttt
    27241 taatttttta taaatttatt tttatttaaa atttcaattt aaacaacaaa aaaacttctc
    27301 atcacaagac aagaagctct tatataaaaa atatacagtg caatttagca attgtcttac
    27361 gatatctctg tatcgtttaa agataatttt ttaatctatc aaatcaaatt atatatttat
    27421 atttcaaatt tttcaagctt ttttaaacaa aatactttaa tataagatat tttatttaaa
    27481 tttcactaaa tttatttact tatataaaaa caaaaaatga tttataagta ttatacaaat
    27541 ggttatttta tctttttaat aacttcctta aaatactcag gtaattctga attaaattcg
    27601 atatattcct tagtagtagg atgtataaat cccaacttct tagcgtgcaa agtttgtcct
    27661 tttaatttaa atttagtttc ttttggacca tatacataat cacctaaaag tgggtgattt
    27721 atagacaaag catgaactct tatttgatga gttctaccag tttcaagcct agctctcata
    27781 tgtgtaaact tatcaaatct ttctacaact tcaaagtgag tgattgcatt ttttccatct
    27841 tttactacag ccatttttaa tctatcctta ggatttctcc ctataggttt atcaacagtt
    27901 attttatctt ctttaaccac accatagcat ataaattcat actccctagt tatagtatgt
    27961 tcctttaact gttctgctag aaaattatgt gcataattgt tcttagctat cataagaaga
    28021 ccagaagtat ctttgtctat tctatgaact ataccaggtc taataactcc atttattgat
    28081 gacaacttat ctttacaatg atataaaatc ccgtttacta acgtattttc atagtttcca
    28141 ggagcaggat ggacaaccat atcctgaggt ttatttatta ttaagacatc atcatcttca
    28201 tatacaatat ctattggaat atcttgaggt aaaacttcta atactttagg ttctggtatc
    28261 tctataacaa tattatcttc ctctttaacc agatatctag ctttttctac tttattatta
    28321 acctttactt ttccatcttt tataattttt tgtatataac ttcttgacat atcacctaat
    28381 tgttctgcta gataaatatc aagtctaact tcttcttcct cttcaagtac taaaaactct
    28441 tttacttcat ccattatatc acctactttt actttcaaaa aataaaacat atatacataa
    28501 aaacacagtt cctacaacta caaatacatc agctatattg aatacatatt cccatataat
    28561 tctaaagtcg aagtaatcta ctacaaaacc taatcgtact ctatcaatta gatttcccaa
    28621 tgcaccagat ataattaata taattcccaa ccttccaaat atatgtactt tccttgtatt
    28681 aagatagtat agtccaaata ctgttgcaag taatgcaaca attataaata tccattgatt
    28741 attttgtaat aatccaaatg ctgcacctct attttcgaca taagttaaat gaaatacatt
    28801 atttattatt ggtattgttg atacatccac caaattattc aatacccata ttttagacag
    28861 ttggtctaaa cctatgagta gaattattat taatatatat agcaatgatt tttcccccta
    28921 taaattattt aaaaaccaat tttatttgaa gcacactatt attattatac aaaaaaaatg
    28981 ctctaaagag caactttatt aaaattgtat tttcttaata aagctagaac aaaatttaaa
    29041 atagtactac tttttttata ttgtagattt ctacatattt aaaatcatat cattatgtat
    29101 aaaaaattta aaaataccat actaatcaat attttttgtg tattttatag attaaagatt
    29161 aatgatgtct gtaatttaaa cttacaatca ccactaatct tcaaacaaat atttttactt
    29221 ttgcacttgc ttatttttat ctaaatgttg tataagttca gatactgtta cgaatttata
    29281 tcctctctct tttaatttag gaattactac ttctaaagct tgtatagttt gtgatttatc
    29341 atttctttta gtgttataat catgtaaaag tattatatta ccattttgga cctttgtaag
    29401 gatagtattt ataattgcat ctactccagg gttagaccaa tctctagggt ctaagtttga
    29461 ccaaagaatt atattcatgc ctttagaaac tataatatca cagacacttt tactcatggc
    29521 tctatatgga ggtctaaata tctttggttc tactcctatt acacttttta taatattttg
    29581 cgtatctgtt atttcttttt caacactact ataactattt tttgcaacat ttatatgtgt
    29641 aaatgtatga ttccctattt catgcccctc atcatattgt ctttttaata attctttgtt
    29701 atattctact ttttctccaa ctacaaaaaa agttgctttt acatcatttt tctttaatat
    29761 atcaagtact tgtggtgtaa aatcctcatc tggaccatca tcaaaagtca atgctaaaat
    29821 tttttcatcc tcatttcctt tttttattat tacatcttca taatcgtctt ttatattgtc
    29881 atttaaacta tatgcttctt ttgaactatc ttgattatgt gtattatgat tatatgtata
    29941 tacacctact atagataata aacatataca tataccccat attattttct tcatgtcatt
    30001 acctcttttc taattcattc tagcaatata ttttataatg tcagtttttt aatctctcaa
    30061 tattccattt ttatttaaat cagttaaatt tgttaggtct tctgaataaa agttagaatc
    30121 ttctacatca gggttttgca ttgcatcacc taataaatta ttttctttct ttgcacaatc
    30181 attacataaa cttgtatctg gcaatatatc caatctttct aaatctattt gattatgaca
    30241 taaatcacaa atcccatatg ttccattctc tattttagat aatgctaagt ctatttgata
    30301 caatcttccc tcttcatgat ttattagact gttttgcata ttttgcatat ataaatctgt
    30361 tcccatgtct cctatatgat tatcataact agataattct cctgatgaat acttttcact
    30421 tgtatgttta gttgtatctc caaataaagt attatctttc atatcctcta ctaaattagt
    30481 taaattttct ctttctttca ataatttatc tttatatttt ttagtatcca tttttaacac
    30541 ctctaatttt aatatttaca tcataaaaat agtatgtgga aaagtaaatt aaacatacaa
    30601 taaaaataag atttgattcg aaaaatggaa tgtctcaaaa tgaaattttt agttcattta
    30661 accctctttt ttatatgaaa tcaaatatat ttttatcctt tcagcaataa aaaagagact
    30721 tatctctatt ttgagatagt ctcttctttg aacataattt aaatacaatt ttttaatttt
    30781 tatagttatt attttactaa cttgccaatt tatgattatt ttgttcttta atatgttttg
    30841 cttttttaaa gaataaaaga ccaagaatta ttgctacaat aacacctatt ccattagata
    30901 tattaactgg tagtctaaat ccttcttttg cttgcattat ataactaaat gttactacag
    30961 tcataaaaag tgctggtaat gtagttatat aatggttttt atttgctttg actaaatatg
    31021 cagaaccagt ccacaacatt atcattgcaa gtgtttgatt tgcccaagag aaatatctcc
    31081 aaattatatt aaaatctata aatgtaagag caacaccaac tgcgaataat ggtaaagcta
    31141 ttaaaaatct atttttgact gcatcttgat tataattcat tgcatctgct attgtcagcc
    31201 tagcacttct aaatgctgta tctccagaag ttataggaca tgccacaact ccaagtatag
    31261 ctaaagctcc tccaataggc cccattaatc caacagatac tgtatttact actgttgctg
    31321 ctccaccatc attaaatatc acattaagtt gaggtatgcc atggaaatat gacatggctg
    31381 ctgctgccca aactaaagct attatacctt ctgcaaccat tgacccataa aatactggtc
    31441 ttgcctcact ctctttctca acacatctcg ccataagtgg tgattgagtt gcatgaaaac
    31501 ctgatattgc tccacatgct attgttataa ataagtatgg gaataaaggt gttccatttg
    31561 gattcatatt ttgtaaattt atatttggta tgttataccc ctttattatt aatcctccag
    31621 ctacacctac tgccataatt aataatgctg ctccaaataa aggatatatt ttaccaatca
    31681 atttatctat tggtaaaaca gtagccataa tataataaag tattatcact ccaacccata
    31741 tttgtgcgtt tacacctgtc aatgtcttta ataatcctgc tggacctgtt acaaatacaa
    31801 ctccaaccaa tactaaaaga ataacactaa atattctcat tgctattttt gcaccatttc
    31861 ctagataaag gcctaccaac tctgatgcag atgtaccttt gtttttcatt gatagatatc
    31921 ctgaagcaaa atcgtgtact ccaccagcaa agattgttcc aaacacaatc cataaaaatg
    31981 ctgatggtcc aaataatgct ccttgtatag ctccaaatat cggacctaac cctgctatat
    32041 ttagaaactg aattaaaaag attctcttcc atttcattgg cacataatct actccatccc
    32101 tacaagctat agctggagtt tgatttttgt cattggttcc aaaaaccttt tctacaaaag
    32161 taccatagac aaaataacct actataagta ctactattga acctaaaaag cttaccataa
    32221 attcatcccc ttagttttta tataattgct ttataaattt ttatgagttt aagaaaacta
    32281 tttccagttc aaatagtaat acttttttat gctaatataa atattaatta cattaagtgc
    32341 atatttaagt acatgaaatg actttatata tgcattaaca gcctaaattc ttttactttg
    32401 cttctactta cagttacttc ataatcacta ttttttaatt ttaatatgta tgtattatta
    32461 aaccatggta taatttcttt tactttggtt aagtttacga tataagacct atgtgttcta
    32521 aaaaatgttt tatcatttat aagattttcg acttctgata tgccttcttt taatataaac
    32581 ttttctttct cagtatatat aaatgtctgc ctttcattag cttcacagta atatatatca
    32641 tcaatatcta ttacaactaa tttatcacct ttccaaaggc taattttatg tgttatttct
    32701 tctatctcct gatttactgc ttccttctta tatttgtata aattactatt tacattaaat
    32761 agttcaatat cactcatctc acttttttct aatttattca gcatagaaat aattctctct
    32821 tcagaatatg gtttcaatat ataatcaaat acatccaaag aaaaagcatc tactgcataa
    32881 ctttcatatg ctgttataaa aacaatttta ggtcttgatt taaactgatt taatgttttt
    32941 gcaagtagca ttccatcaag atgaggtata tttatatcta aaaaaattac atctatttta
    33001 ttttcctgaa taaagtctaa cacctctata ccattggtaa attcacttac tacctcgatt
    33061 ccacttttat tttcaataaa atatctcaat tcctttcttg ctggaaattc atcttccact
    33121 attatagctc tcatacttct actcctttac ataaaatact atcaaagtcc cattatctat
    33181 tcttcttata ttaagccctc ttccatacat cagtttaagc cttaaatgta cattataaag
    33241 cccaatctta ttttctggca tattatcttg atatacatta tttataattt cctcacttat
    33301 acctatacca ttatcctcta ttgatattct cacagtattt tctaatgaat acggtaactt
    33361 ttttatggat attttcacta caccagctct accactttct aaaataccat gtattattgc
    33421 attttccact aatggttgta taatcaaact tggaatcttt atatttacat cttctatatc
    33481 ataagataca gttagtaatt ctccaaacct agctttttct atctctacaa aagatttaac
    33541 ttgttcaatc tctttattta tatcaattaa gttatcacta tattcaagat tatatcttag
    33601 ataagttgat aaatttatta ttaactctct agccttatct ggactaaatc ttataaatga
    33661 agctattgtg tttagggaat taaacaaaaa atgtggatta atttgtcttt gaagtgcttt
    33721 tatttctgct ttatttctcg cttctatatc ttttttatct ttctcaatcc cctctactat
    33781 agatataaca aatcctattc caatctgccc aactattaaa ggtaaatata ttccaccgat
    33841 tatttgaatt gctaaagaat gtggatatga tattaagtat ataagtaata tagtaaaact
    33901 ttcagaaatc atgcctacca atattccata cattactcta tgttgttttg gtatcctctt
    33961 atatagaaat cctgataata cacctgctag tatacttgat aaaagacatg gaacagatgt
    34021 tatcccccca atatccataa aatatctatg aatccctgaa aaaactcctg ctgtaatacc
    34081 taccatcgga ccaaataaaa tgccacctga tactatagat attattctag tgtttactat
    34141 tgaccccata taatttatac cactataagt tccaaatatg gctaaaaaag taaaaactaa
    34201 tgctatacag accaagtcat taaaactata ttcttccttt tgaaatatct gcttaaatat
    34261 ttttaacttt gttattagaa gaaacaatac tacaataagg cttgtctttt ctattaatgc
    34321 gattaaaatt gatgttttca taatccccct ttaaaaaata aatttttaca cactctaaat
    34381 ttattatggt tgttataaat tacatatttg aagtaatcct atcacaaaac tttccacatt
    34441 taatctttta attaaataag aaatagttgt acttctatta acaactaata ctagctagca
    34501 taagcttgta ataacttgta gttattatta actttacaat tctagtattt aattttatac
    34561 tttagaaatc tcttttctta gaaataatac tttcgaatat catataatac aatattatgt
    34621 agattcttac tcatacaaca tatttcttta aaaattttat actattcttt gttcaaatat
    34681 ctcatttgat ttaattgtgt taaacacaca ttatcatctc tctgttatat atttattata
    34741 tagccgtata tcgataaagt aaataaatcc catatttaaa ataatatgtt tgacaataaa
    34801 ttattataat gtatatttac cataataatt tgtcaacctt gaaagttact tctataatta
    34861 ttgttaaata attcttctaa aaaaaatacc tataaatttt attttctgaa atacatagtt
    34921 ataactattt ttatcacgta taagaataaa aattccagaa aatttttatt atctaagtta
    34981 atataaaaca tattattta
//
LOCUS       DAEQCW010000034        33379 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.034, whole genome shotgun sequence.
ACCESSION   DAEQCW010000034 DAEQCW010000000
VERSION     DAEQCW010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33379)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33379)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33379
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.034"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            119..769
                     /locus_tag="KRO40_001629"
     CDS             119..769
                     /locus_tag="KRO40_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /protein_id="HBH2092450.1"
                     /translation="MKAEKTSIYPIIKNNLNKISIVEYKKGQRFVASDKDLQEVFFII
                     EGVALVECTTRGGNKFLVDIVPENEFIGKISYIYEHNLKCDIFAKTNIKLFRFEKNVF
                     EEFYLKPDFIALFHRKCTRRIYELYKTRMVRELFSCTEVIAYCISNKQENNVCNIKAI
                     RNFSEIYSISRKSRYHSLLKLTEKEIVKKMGNTYEILNYDELHKLAFEVKEFLEDE"
     gene            complement(909..2285)
                     /locus_tag="KRO40_001630"
     CDS             complement(909..2285)
                     /locus_tag="KRO40_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2092451.1"
                     /translation="MQELFSLKDENKRFYKILLSLCIPIIIQNLISTSVNVIDTIMIS
                     SLGETSVASVGVANQFFFLFNMSLSGITGGAGVFISQFYGKKDVSNIRKVTGLTCVLA
                     IVLSFVFVIPALLTPKPIIHIFSYDSEVVKLCIDYFSIAVFSYPLIAVSTVFSTGSRG
                     VRNPKLGMICSAFALVTNVILNYGFIFGNFGLPALGVKGAALATVIARICELILMITY
                     VYLYKKDYILKFGLKNLKAIDKIFIKSFSSKSFPIFVNDSVWAIGTVLYSVAYARAGT
                     SAIAASQIATSTGNFFIMTAVCIASGASIMLGNELGADHIKRAIEYAKKFSILVFSAG
                     LILGIILILNIPLLLKMFSVSDSLASDITKIFFIMGILMALKSFNTLVIIGILRSGGD
                     TKYALFLELGCMWLASIPLTFIAAFKGAPIFVLVLLTYSEEVVKFIFGVPRALSKKWA
                     INIVKEID"
     gene            complement(2301..4214)
                     /locus_tag="KRO40_001631"
     CDS             complement(2301..4214)
                     /locus_tag="KRO40_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH2092452.1"
                     /translation="MIVLSCNNLNKSFGIDSILENISFTVNEGDKIGIIGVNGTGKTT
                     LFKIISGIYGYDSGDIYTSKDCEIGYLEQNTNFYSDNTILEEVLEVFKNLIEMESYLR
                     ELEVKISEESTKTNSPIIEKIMDEYSHKLELFSDLNGYGYKSEAKGVLKGLGFSDNDM
                     DKPISILSGGEKTRVLLGKLLLKKPTLLLLDEPTNHLDSEAIEWLEVFLKQYKGTVML
                     ISHDRYFLDQSVNRIFEVHNKKLKVYNGNYSKFVELSKIEKELELKKFEDQQKEIKKQ
                     EESIERLKAYGREKHLKRARSKEKALDKVDVLDKPEAYRKKARIQFTPSVQSGNDVLQ
                     IRDVSMGYGERILFKDLDLDIYRGEKVALIGANGVGKSTLFKIITNELQPLSGNIKFG
                     TNVHVSYFHQEQKTLNLDNTIIDEIWENNTHLTQTTLRNMLGAFLFVDEEVFKKISTL
                     SGGERARVAILKLILSNANLLLLDEPTNHLDIDSKEVLEEALTNYDGTIFTISHDRYF
                     LNTVVDKILVLDENGITEYLGNYDYYIDKKRQIQEMSIIEEKEEKTRTQIKDEKRKER
                     EQREIEKKNRIKRQNIEKEIEKLEIEIEKLDILLCQEEVYSNPDKAKEVSQEKINLEN
                     NLASLYDEWEEFM"
     gene            4350..4982
                     /locus_tag="KRO40_001632"
     CDS             4350..4982
                     /locus_tag="KRO40_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HBH2092453.1"
                     /translation="MLGNKNISMAVIRRLPKYHRYLGDLLDRDIQRISSKELSDIIGF
                     TASQIRQDLNNFGGFGQQGYGYNVEALHTEIGKILGLDRPYNAVLVGAGNLGQAIANY
                     AGFRKAGFEIKALFDANPRMIGLKIREFEVLDSDTLEDFIKNNNIDIAVLCIPKNGAQ
                     EVINRVVKAGIKGVWNFAPLDLEVPKGVIVENVNLTESLFTLSYLMKEGK"
     gene            5121..5660
                     /locus_tag="KRO40_001633"
     CDS             5121..5660
                     /locus_tag="KRO40_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBH2092454.1"
                     /translation="MVFVEELWKKAIEFHGHECPGLAIGFKAALAAKKYLGCKQSGDE
                     EIVCISENDACGIDGIQVVLSCTMGKGNLLLRMTGKSVYHFFNRENGKSIRIYVKSKP
                     FEMDREGYKRYLLESDFEEIFEITDTKLRLPEKARIFKSLKCEVCGEFASEQYIRIEE
                     GKKVCLDCFDKYERFYEEY"
     gene            complement(5836..6006)
                     /locus_tag="KRO40_001634"
     CDS             complement(5836..6006)
                     /locus_tag="KRO40_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004619190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2092455.1"
                     /translation="MAYKITDACISCGACEAECPVSCISAGDDAYVIDAGSCIDCGSC
                     AGACPVDAPQPE"
     gene            6291..7358
                     /locus_tag="KRO40_001635"
     CDS             6291..7358
                     /locus_tag="KRO40_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HBH2092456.1"
                     /translation="MKNKLVYICIMSLLLFVVGCSNNPNKESTIKKDSKNNQSQVKEE
                     KREPVKKDITISFAGDVTMGNYKGSSYYGSFDHEFKRQGEDYNYFLKNVKPVFEKDDL
                     TVVNLEGPLTTASNAKEKKFAFKGKPGYVNILKSGSVEAVSIANNHSEDYFEEGMKDT
                     QFILDENKINYFGLGKDAVVDVKGIKVGLLGYNGLSTEYNEKNLKQMEDDIKSLKKKS
                     DVVVVYFHWGIELDYYPDKKQKDFAHYAIDKGADLVMGSHPHVIQGIEKYKNKYIAYS
                     LGNFCFGGNKNPSDTDSYIYQQTFTFSDNKLTSIKEPNIIPTSITSSNSRNNYQPKIL
                     DGSEKDRVLNKLEKISKDLNK"
     gene            7528..9429
                     /gene="cooS"
                     /locus_tag="KRO40_001636"
     CDS             7528..9429
                     /gene="cooS"
                     /locus_tag="KRO40_001636"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBH2092457.1"
                     /translation="MACNTCKMCESADKKLESFVASKDVETAFHRTEDQKVKCGFGLQ
                     GVCCRLCSNGPCRVTPKSPRGICGADADTIVARNFLRAVASGAACYLHVVENTAKNLK
                     NVGITKGVVKGEKTLNQLAEMFGIESDEKYDKCIKVADKVINDLYKSRDDKMELVEKI
                     AYAPRVKKWKELGIMPGGAKSEVFDAIVKSSTNLNSDPVDMLVNCLNLGISTGLYGLT
                     LTNLLNDVMLGEPVIRMAPVGFNVIDPDYINIMITGHQHSTFANFQDRLKDEDVIKLA
                     QSVGAKGFKLVGCTCVGQDLQLRGEHYQEVFAGHAGNNFTSEAVLSTGAIDIVLSEFN
                     CTIPGLEPIADKYKVKMVCLDDVAKKANAECIGLDRSKLDELSNTLIEKALESYKERR
                     GSIEIDIPKDHGFEQSLTGVSEKNLKAFLGDSWKPLINLIAEGKIKGVAAVVGCSNMT
                     AGGHDVNTVELTKELIKKDIIVLSAGCSTGGLENVGLMSPGAEELAGENLKEVCKTLG
                     IPPVLNFGPCLAIGRLEIVATELAAELGIDLPQLPLVLSAPQWLEEQALADGAFGLAL
                     GLPLHLALPPFITGGKLVTEVLTEKLKDLTGGHVIVNPDPKSSANQLEEIIIDRRKNL
                     GLKDVECNA"
     gene            9422..9895
                     /locus_tag="KRO40_001637"
     CDS             9422..9895
                     /locus_tag="KRO40_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2092458.1"
                     /translation="MHRIFINKDLCTGCKSCVLACMLKHNKDYDMYTLDLENIDNDSR
                     GHIELDSRHNNPVPILCRHCDEPECVLACMSGAMHKDSESGIVSYDEEKCGSCYMCVM
                     SCPYGLLKPDDRSKQNILKCDLCKDEEYPRCVANCPSGAIELQKEENDELCSVRG"
     gene            9870..11096
                     /locus_tag="KRO40_001638"
     CDS             9870..11096
                     /locus_tag="KRO40_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH2092459.1"
                     /translation="MNYVVLGASAAGINAVKTLRELDKDSNIVVISKDENVYSRCMLH
                     HVISEHRTLKQINFVDEDFMEQNNVKWIAGKTVKGIDINKKVVQTEDITVNYDKLLIA
                     TGASSAIPPIKNLRDGNFVYSVRNIDDIYKIKEKAQNSKNVVIIGAGLVGIDALVGLF
                     KYEQLNISVAFMEKYILDRQLDEYTASVYENKFKEKGVKFYPSASIQEIVLDNSKNVT
                     GVAFSNGEVLDADMVIVATGVKPNADFLDGTGIEYDRGIIIDDMCQTTQKDIYAAGDV
                     VGKNAIWPLAVKQGIVAAYNMVGKDKKIEDEFAFKNSMNFMDIPTISIGMNTPVDDSY
                     KVLTRHGINDYKKFVFKDNVIYGAVIQGDISYVGVLTYLIKNKVEIYDLENRIFDICY
                     ADFFNIKENGEFCYSV"
     gene            complement(11235..12422)
                     /locus_tag="KRO40_001639"
     CDS             complement(11235..12422)
                     /locus_tag="KRO40_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2092460.1"
                     /translation="MNITKNFLKDYLEKFGETPFLVRLKDEEEFLIGEGSPQFKVIVN
                     NDISKSELLKSTSLALGEAYINRDIEVEGDLFLTLNLLLKQIDKFNIDNSAVKHLLHS
                     SNSMRHQKKEIHAHYDIGNDFYSLWLDKTLSYSCAYFRNDNDTLYDAQVNKVHHILTK
                     LNLEEGMSLLDIGCGWGFLLIEAAKKYKIHGVGITLSEEQFKEFNARIKEENLQDYLE
                     VRLMDYRELKKSDLMFDRVVSVGMLEHVGRENYELFIKNVNAVLKDGGLFLLHYISGL
                     QESYGDPWIKKYIFPGGVIPSLREMIHICSDYKYHTIDVESLRLHYVKTLLYWQKNFS
                     ENLPKIKEMFDDKFIRMWDLYLCSCAAAFNTGIIDIHQILFTKGIKNDLPLTREYMYN
                     CSK"
     gene            12695..13519
                     /locus_tag="KRO40_001640"
     CDS             12695..13519
                     /locus_tag="KRO40_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HBH2092461.1"
                     /translation="MEVYALVGSSGTGKSFKALEFAYENDIEYIIDDGILIYKNKVLA
                     GISAKQANTTIEAVKRAIFYNLEHRQEVREAIKKENIRKILIIGTSKKMVNQIVERLS
                     IGRVCKFINIQDISTKYEIEIAKQARKEGNHVIPVPAVEIKSMASGLSINSLKRLFRK
                     GNNRNMVVLEKTIIRPTFSYIGKFYISADVIKQIIEYEVYNFGSIDRINKINIENCNN
                     FMNIFVSININDLETIKKIEDIQQTIKKSIEKMTLVNVQKIDINIHKIKKINFLQC"
     gene            13648..14913
                     /gene="gluD"
                     /locus_tag="KRO40_001641"
     CDS             13648..14913
                     /gene="gluD"
                     /locus_tag="KRO40_001641"
                     /EC_number="1.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-specific glutamate dehydrogenase"
                     /protein_id="HBH2092462.1"
                     /translation="MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSI
                     PVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIP
                     YGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVD
                     EYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQ
                     GIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLN
                     FPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVF
                     AERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIK
                     EEYNVTMREAAYMHSIKKVAEAMKLRGWY"
     gene            15126..15716
                     /locus_tag="KRO40_001642"
     CDS             15126..15716
                     /locus_tag="KRO40_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBH2092463.1"
                     /translation="MHFKSKDLNLKYLVLFLKIVYWFNPFICIMEKYMDLDCEFYCDE
                     RVLKNCTVQQKQEYALTIVNSMKRGTNFSNKFVAGLNKQSDIIKRVMNMFSEKHKNGI
                     LMALIISLFSSITFFKFDSTSIIEENDFLERLRYTFEGRQEDMFVTIDFTYADTPIKL
                     RKEHEENCRVNGIVPKDSDSIEIIPRFYKDCMDLKK"
     gene            16046..17179
                     /locus_tag="KRO40_001643"
     CDS             16046..17179
                     /locus_tag="KRO40_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBH2092464.1"
                     /translation="MSNFILNGIFRTVIVSSLSILLILIFKKNVFKRFSKKFNYYIWM
                     IVVIKLFLPFTYYTFTINILRSKKHININNINLEGFNNVSTISNNIILYTWIITVVVY
                     LIYTIFKYIKLKNLINDLSYDVDDREIVNLYKNILEEFNITKDIKLKYSYEVETPAFF
                     NSCVLLPPHEYKLKELDWIFRHELMHFKSRDLYLKYVILFLKTVYWFNPFIYIMDKHI
                     DLDCELYCDERVLKNRNSEEKKDYALTILNAMRKGSNTSNKFIAGLHKQSDIKKRVMN
                     MFNEKYKNGILMALTLCLLSSITFLKVNSTSIVNLNVLPKGFEDLRTVSSIRFSVIGF
                     TYADAPKNMREEYKINCESLGLIPKDSDKIEVGIEYYDSLLND"
     gene            18095..19117
                     /locus_tag="KRO40_001644"
     CDS             18095..19117
                     /locus_tag="KRO40_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH2092465.1"
                     /translation="MKKKILIPVFASVMALSVSSIVNADEVNDSSQNKDDKTNTELNL
                     GEYKEVKYKVAKIKDGVAIKIREEGQVQNIAYSGDEFTVLGTQGEWVKVKVEDGEGWL
                     ATRYVDISEGVGYTNADKVNLRKDKSESSEVIEELEKGSSLLVLEDNGDWLKVKDGET
                     EGYVKSSYISDKAPVIEEPQVNPSIDQNVDSTNNNQQNNANTNQQNNNSNVPTANSNA
                     VQAVLNLAYSKQGCPYVWGAEGPNTFDCSGFTQYVYRNAVGKNIPRTSKAQSKYGQTV
                     SKANLQPGDLVFFTTNGSGSVSHVGIYVGGGNMIHSPSTGKTVSVTSINSSYYTARFV
                     TAKRIL"
     gene            19413..20333
                     /gene="pyrB"
                     /locus_tag="KRO40_001645"
     CDS             19413..20333
                     /gene="pyrB"
                     /locus_tag="KRO40_001645"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase"
                     /protein_id="HBH2092466.1"
                     /translation="MLKSRNLIQPEDFSIEEIDEILELAQKIIDNPSKYSRICEGKLL
                     ATLFYEPSTRTRLSFESAMNRLGGRVVGFSEPNSSSASKGETLGDTMRIVSGYVDIIA
                     MRHPQSGAASEAARYTEVPFINAGDGKNQHPTQTLTDLLTIKSLKGTLESHTIGLCGD
                     LKYGRTVHSLVKAMARYKNTKFVFIAPEELKMPDYIKEAIKGHAYYETNNLDDVIGSL
                     DVLYMTRVQQERFEDKSEYERLKNYYILNKAKLEKASKDMLVMHPLPRVNEIDIDVDS
                     DDRAVYFKQAKYGMYVRMALIIKLLGINED"
     gene            20372..21064
                     /locus_tag="KRO40_001646"
     CDS             20372..21064
                     /locus_tag="KRO40_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HBH2092467.1"
                     /translation="MYKILENIYIGEDMYRMKVKGNFEGKMGQFYMLRAWDTYPVLSR
                     PISIHDIDEEGITFLYKVVGEGTQILSNLKVNDNIKLEGPYGNGYAKVDGKVALVGGG
                     IGVAPLYLVAKNIKNCDAYLGFREDVILEDEYKQVCNKVYTTVGNTFVTDIIDVEKYD
                     YILTCGPTPMMEKLVKMVEGTKTRIMVSLENHMACGVGACLVCTCKTNGGNKKTCKDG
                     PVFWGEDVIFNG"
     gene            21057..21959
                     /locus_tag="KRO40_001647"
     CDS             21057..21959
                     /locus_tag="KRO40_001647"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBH2092468.1"
                     /translation="MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISS
                     KGLTLNKKPGNNGMRVHETPSGMMNSVGLENPGVQGFIDYELPFFSKLDLVRIANVGG
                     GTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLP
                     LVIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPA
                     IKPIALRMVHEVCKNVNIPVMGMGGITKATDAIEFIMAGATCIQVGTANFMNPRIGIE
                     IIDGINEFMDREGIKSLDEIRGII"
     gene            22044..22628
                     /locus_tag="KRO40_001648"
     CDS             22044..22628
                     /locus_tag="KRO40_001648"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HBH2092469.1"
                     /translation="MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEY
                     AAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGRQLGKEAVFTERKDNTMELRRGF
                     EVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIK
                     LDIQVYESDECPLCKEGKLPVVKPGSREFKELGM"
     gene            22966..26010
                     /locus_tag="KRO40_001649"
     CDS             22966..26010
                     /locus_tag="KRO40_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH2092470.1"
                     /translation="MKKTWKRLCTGFLALATVVTALPTTPVHAESKQYWTESNERVGI
                     VEKVMNDGSIGSTFNEGHLTVEGEDAYCIDINTDFKNGYKTRADASSRMSIDQISDVA
                     LSIEYVKQYTDSHSGIGKNHAYLLRQLVVWQRLSVHLGWQCDNVRASYDEIPKATQDE
                     VFAGAKAFVKENKGRYECGGYIYSGEGQELGQFWAKLNVGNAKLQKTSSNTSITDSNG
                     NYSIAGATYGVFSDKDCTKQLATLTTDENGNTDVAEVKAGTVYIKELSAPAGYKVDKT
                     VYSLKVEAGKTATLKVSDTPKVTDTLIELFKIDMETQKDNPQGNASLAGAEFTWKYYA
                     GFYNKENLPAEATRTWVTKTIAETDSDGTTHYITKLADAYKISGDSFYMQDGKAVLPL
                     GTLTVEETKAPNGYLLDGAYMQAGDKPEQIKGLYVTQITEDGDLAVLSGSNQFSVSDK
                     VIRGGVKIQKRDLETGDTKPQGSATLKDTAFDIISLNDNAVLVEGKLYKKNEVLKTIH
                     TDIEGVASTSADLLPYGKFRIVESEAPDGYLTDGAKPIDFAITENGKIVDLTDEAHSI
                     YNQIKRGDIEGIKIGAGTHKRLADVPFRITSKTTGESHVVVTDDNGQFSTSADWASHK
                     HNTNAGKTSEDGVWFGTSEPDDSKGALPYDTYIIEEMRCNSNKGFELIPPFEIVVSRN
                     NLVIDLGTLTDEYEKEISIHTTATSKDGEKTILAGKEVTIVDTVKLDGLTKGTKYQLK
                     GWQMLKEENAELLIDGKRVENDYTFVADDEEMKVEISYIFNASALGGKNLVTFEELYD
                     FSNPDEPVKVAEHKDIEDDGQTVLITERIIKIHTTATDKDGNKELEAGKEVTIIDTVT
                     LEGLEVGTQYKLVGWQMLKEENAELLINGKRVESDYTFTADSETMKVEVAFTFDATSL
                     DGKQLVTFEELYDLSNPDEPKKVTEHKDIEDKGQTITFKEKPEEPEKPETPPTPEKPN
                     RPSDSPKTGDSTNVMAFVVMLLASAGGLAGTYLYKRRKMKKS"
     gene            26249..26575
                     /locus_tag="KRO40_001650"
     CDS             26249..26575
                     /locus_tag="KRO40_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH2092471.1"
                     /translation="MEMKYVVPDMAQSFGTLEFAGESEPVFERDKNNRRVLARRSYNL
                     YSDVQKGENVVVEIPVQAGEKHFKYEQKVKLVNPKLYGRGYAIGDMGHTDYVLVADDI
                     VAVEEK"
     gene            26591..26980
                     /locus_tag="KRO40_001651"
     CDS             26591..26980
                     /locus_tag="KRO40_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH2092472.1"
                     /translation="MRLSNGFVIDKEKTFGELKFTAVRDVFLQNEDGTPSTQLKKRIY
                     DLKCSLHGGIIPVSVPPEVPLREFPYNAVVELVNPVADTVSRKTFGGADVDWYVRAED
                     IVLKNKGNQNAGNPQNNNTQGQPKKQN"
     gene            27050..27466
                     /locus_tag="KRO40_001652"
     CDS             27050..27466
                     /locus_tag="KRO40_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBH2092473.1"
                     /translation="MKVLVSSCIMGKNCKYNGGNNLNPKVVEFLKDKEVIEICPELLA
                     NMPTPRPSAEIVNGIVMDINGNIVDEEYRHAVQLALNEIRSMEIDLVILQSRSPTCAV
                     KNIYDGSFTGKLIKGQGLFAQALIEAGYKVLDSEDF"
     gene            27540..28934
                     /locus_tag="KRO40_001653"
     CDS             27540..28934
                     /locus_tag="KRO40_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008787614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2092474.1"
                     /translation="MQKIWNKGHRIRASDKHLVYHFSIGTLLFVFVTVLLLLNIKQLM
                     CTDWEHFSLLENGLTLSPYNFITILIATGVCALVAFLYYRFCYDNFKKLLHRQKLARM
                     ILENKWYEADTVQDSGFFTDLQSRSREKIVWFPKIYYQMEKGLLHIRCEITLGKYQDQ
                     LLRLEDKLESGLYCELTDKTLHDGYIEYTLLYDMIANRITIDEVRAENGCLRLMKNLV
                     WEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNADLADLGTVMGNVY
                     HTKEEMIDCVNAFYEGMVQRSEEMKRHPNYKTGENYAYLGLPPCFLIFDEYVAFFEML
                     GTKESVSLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISEL
                     GYGMLFGSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQTIGSLAQARQ
                     DGTATCEAKGDGTD"
     gene            29118..30314
                     /locus_tag="KRO40_001654"
     CDS             29118..30314
                     /locus_tag="KRO40_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH2092475.1"
                     /translation="MVLNEEQWIKELREKRIAYGISQGRLAVVSGITREYLNKIESGK
                     MKPSKELLETLNKELARFNPEAPLTMLFDYVKIRFPTLDIQHIIKDILKLNINYMLHE
                     DYGHYSYTEHYSLGDIFIYTSADEEKGVLLELKGRGCRQFESYLLAQQRSWYDFLMDA
                     LIDGGVMKRIDLAINDHTGILDIPELAEKCRKREYIGKSRSYKFYQSGELIKHREDDR
                     EYMGRTLYLGSLKSDVYFCIYEKDYEQYVKLGTPLDEADIINRFEIRLRNERAYYAVR
                     DLLTYYDAEQTAFSIINQYVRFVDEEPDKRKNDWKLNDRWAWFIGDNRQSLKLTTKPE
                     PYTLDRTLRWVQRQVAPTLKMLKKIDKGNGTDYMETIEQQAKLTEKHEMIIKQQTTPA
                     KDLVES"
     gene            30327..30461
                     /locus_tag="KRO40_001655"
     CDS             30327..30461
                     /locus_tag="KRO40_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017143882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3789 domain-containing protein"
                     /protein_id="HBH2092476.1"
                     /translation="MWVLLKDFLLVSMGMGIGVVLMCILNVGKEADCEMKQLKESEDN
                     "
     gene            30462..30683
                     /locus_tag="KRO40_001656"
     CDS             30462..30683
                     /locus_tag="KRO40_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092477.1"
                     /translation="MNFGQNLYQWFLSNAQSLVLMAIVVIGIYLGFKREFSKLIGFLV
                     VALIAVGLVFNAGGVKDVLLELFNKIIGA"
     gene            30762..31268
                     /locus_tag="KRO40_001657"
     CDS             30762..31268
                     /locus_tag="KRO40_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2092478.1"
                     /translation="MIIYSKLEINRIKDFWELLNRLDTETDYMMYEPNERKAKTTIQE
                     LKLDIQDNVIQGFDFLQVATENDKIVGYIRAERGKFERNFHTAYIVIGILKKYRGKGI
                     GTTFFNNLDLWAKTNNIVRLELTVECCNNTAKNLYEKNGFKIEGIRKKSMFVAGSFVD
                     EFYMAKIL"
     gene            31329..31748
                     /locus_tag="KRO40_001658"
     CDS             31329..31748
                     /locus_tag="KRO40_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002578899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBH2092479.1"
                     /translation="MNEREKIIRLWFDMWLKQQDLGMDKIFTEDVVYTESWCPKYKNL
                     KTVKHWFNEWNTRGKVIIWDIKQFFHKENQTVVEWYFKNEMNTGSVEEFDGISLIEWT
                     EDNKIKSLKEYGCNLNNYNPYQHSDSPQFRDEKISWF"
     gene            31840..32136
                     /locus_tag="KRO40_001659"
     CDS             31840..32136
                     /locus_tag="KRO40_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005339688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2092480.1"
                     /translation="MNDIFKDMQAKVGCDYLSDLPSYKRKVWHEMKRLNPADHEERQL
                     EDFSKYVFGMSYQTLKDVMKQQKGREEQCRKQGCWWKRKEQLAKKQHHTGSTCR"
     gene            32055..32558
                     /locus_tag="KRO40_001660"
     CDS             32055..32558
                     /locus_tag="KRO40_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH2092481.1"
                     /translation="MQETRVLVETKGTTGEETTSYWFDLPIDVAEFEEKLGVGAESQD
                     YCIIEKVLPFADEIHEHTSVYQLNELDFMYRQLSSDMQEEYTALLTVCENLEALYICR
                     NVITVYPDCKSMIDVARQKLMNDPTFKHLSEDCQEYYFDFEAYASHLQEHGKFLVTEH
                     GIFELPE"
     gene            32576..33079
                     /locus_tag="KRO40_001661"
     CDS             32576..33079
                     /locus_tag="KRO40_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH2092482.1"
                     /translation="MIDDMAVYIANLGKYNEGYLVGAWFTFPIDEEDVKEKIGLNEQY
                     EEYAIHDTDNFPIAIGEYVSIEELNEMYEMIEELPDYIVECLDEFISHYGTLEEVVEH
                     KDDIYYYPDCETMTDVAYYYIDELQALGDIPPSLQNYIDYEAYGRDLDMGGYFIETSR
                     GMCEIPY"
     gene            33189..>33379
                     /locus_tag="KRO40_001662"
     CDS             33189..>33379
                     /locus_tag="KRO40_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009274602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2092483.1"
                     /translation="MKKIKSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFII
                     ILFGDIPPLSMIEGAFLKY"
BASE COUNT        12334 a         4435 c         6296 g        10314 t
ORIGIN      
        1 gtagaatgaa tttgtcaagt ttaatttagt tgtaatttta tcttttatta aaaataatat
       61 aaattaaaac atataaataa aatattttat acaatatatt gtaaaggagg taactttgat
      121 gaaagcagaa aaaacaagta tatatccaat tattaaaaat aatttaaaca aaatatcaat
      181 tgttgaatat aaaaagggtc aaagatttgt agcatcagat aaagacttac aagaagtgtt
      241 ctttataata gagggagttg cattagtgga gtgtactact agaggaggaa ataaatttct
      301 tgttgacatt gtacctgaaa atgaatttat aggcaaaatt agttacatat atgaacataa
      361 tttgaaatgt gatatatttg caaagactaa tataaaatta tttcgatttg aaaaaaatgt
      421 atttgaagag ttttatctca aaccagattt tattgcacta tttcatagaa aatgtacaag
      481 aagaatatat gaattatata aaaccagaat ggtaagagaa ctattttctt gcacagaagt
      541 tattgcctat tgtatatcaa ataaacaaga aaataatgtc tgcaatataa aagctattcg
      601 taatttcagt gaaatctatt caattagtag aaaaagtaga taccattctc tgctaaagtt
      661 aactgaaaag gagatagtaa aaaaaatggg taatacatat gaaattttaa actatgatga
      721 attacataaa ttggcatttg aagtaaaaga atttttggaa gatgagtaaa aattgttact
      781 taatcaaaat aaagtataat aatttctgta aaaaatagaa atagtctcac tgaaaatcaa
      841 aaatacttta gttattttca atgagactgt ttagaaatat tgtatactta taatgtatag
      901 tataattatt aatcaatttc ctttactata ttaatagccc attttttaga taatgctcta
      961 ggaacaccaa atataaactt aaccacttct tcactataag tgagcaaaac gagtacaaat
     1021 ataggtgcac ctttaaatgc agctataaaa gttagaggaa tagaagctaa ccacatacat
     1081 cctaattcta aaaatagagc atatttagta tctcctccac ttcttaaaat accaattata
     1141 accaatgtat taaaagattt aagagccatt agtattccca ttataaagaa tatcttagtt
     1201 atatcagaag ctaagctatc agaaacacta aacattttta ataataatgg tatatttaaa
     1261 attaaaataa ttccaagtat taaaccagct gaaaatacaa gtatagaaaa ctttttagca
     1321 tattcaatgg ctcttttaat atggtcagct ccaagttcat ttccaagcat aatagatgca
     1381 ccagatgcaa tacatacagc tgtcattatg aagaaattac ctgtactggt tgctatctgg
     1441 ctagctgcta tagcagaagt accagctctt gcatatgcaa cagaatacag gacagttcca
     1501 attgcccata cagagtcatt tacaaatata ggaaagcttt ttgatgaaaa agattttata
     1561 aaaattttat caatagcttt tagatttttt agaccaaact ttaatatata gtctttttta
     1621 taaaggtaaa cataagtaat cattaaaatt aattcacata ttctagcaat aacagtagct
     1681 agagcagcac cttttacacc caatgcagga agaccgaagt taccaaatat aaatccataa
     1741 tttaaaataa catttgttac aagtgcaaat gcactacaaa tcatacctaa cttaggattt
     1801 ctaacacctc ttgaaccagt actaaataca gtacttacag caattaatgg ataactaaat
     1861 actgcaatac taaagtaatc tatacaaagt tttaccacct cagaatcata cgaaaatatg
     1921 tgtataattg gctttggtgt tagtaaagca ggaataacaa atacaaaact taaaacaatt
     1981 gccaatacac aagtaagacc tgtgactttt cttatattac tcacatcctt ctttccataa
     2041 aactgtgaaa taaaaactcc agcacctcct gtgataccag ataaggacat attaaaaaga
     2101 aagaaaaatt ggtttgcaac tccaactgaa gctacagatg tttcccccaa actacttatc
     2161 ataattgtat ctattacatt tacagaagta gaaattaagt tctgtatgat aataggtata
     2221 cataaagata gaagtatttt ataaaatctt ttattttcgt cttttaaaga aaatagttct
     2281 tgcaaataat cctctccttt ttacataaat tcttcccact catcatatag agaggcaagg
     2341 ttattttcta aattaatttt ttcttggcta acttctttag ctttatctgg attagagtat
     2401 acttcttctt gacataaaag tatatctaat ttttcaattt caatctctaa cttttcaatt
     2461 tctttttcta tattttgtct ttttattcta tttttctttt ctatttctct ttgttctctc
     2521 tcttttcttt tttcatcttt tatttgagtt ctagtttttt cttctttttc ttctataata
     2581 ctcatctctt ggatttgcct ttttttatct atataataat cataatttcc cagatattca
     2641 gtaattccat tttcatctaa aactaaaatt ttatcaacaa cagtatttag aaagtatcta
     2701 tcatgtgata ttgtaaatat agtcccatca taattagtta aggcctcttc aaggacttcc
     2761 ttagaatcaa tatctaggtg attagtaggc tcatctaata acaataagtt tgcatttgat
     2821 agtataagtt taagtatggc aactctagct ctttctccac cactcaatgt agaaatcttc
     2881 ttaaaaactt cttcatctac aaataaaaat gcccctaaca tatttctcaa agtagtttga
     2941 gtaagatgag tattattttc ccaaatctca tcaattattg tgttatctaa attaagagtt
     3001 ttttgttcct gatggaagta ggaaacatgt acattagttc caaatttaat attgccacta
     3061 agaggttgta gttcattagt tattatttta aataatgtag atttgccaac accatttgca
     3121 cctataagtg caactttttc ccctctatat atatctaaat ccaagtcttt aaaaagtatt
     3181 ctttctccat aacccataga tacatctcta atttgaagaa catcattacc actctggaca
     3241 gaaggcgtaa attgtatacg agcttttttc ctataagctt ctggtttatc taaaacatct
     3301 actttgtcta atgctttttc tttacttctt gcacgcttta ggtgtttttc tctaccataa
     3361 gcttttagtc tttcaattga ttcttcttgc ttttttattt ctttttgttg gtcttcaaat
     3421 ttcttaagct ctagttcttt ttctatttta gataactcaa caaatttaga gtagttacca
     3481 ttatatactt taagcttttt attgtgaact tcaaaaattc tatttacgga ttggtctaag
     3541 aaatatctat catgagatat taacatgaca gtccctttat attgttttaa aaatacttct
     3601 aaccattcta ttgcttcaga gtctaagtgg ttagtaggtt catcaagtaa caatagagtt
     3661 ggtttcttaa gaagtaattt tcctaaaaga actctagttt tttcaccacc agaaagtatg
     3721 cttattggct tatccatatc attgtcacta aatcctaatc cctttagaac tcctttggct
     3781 tcagatttat atccatatcc atttaaatct gaaaataatt ctagtttatg tgaatattca
     3841 tccatgattt tttctataat tggagagttt gtttttgtac tttcttcaga tattttaacc
     3901 tccaattctc ttaaatagga ttccatttct atcaaatttt taaaaacttc tagtacttct
     3961 tccaaaatag tattatccga ataaaaattg gtattttgtt ctaaatatcc gatttcacaa
     4021 tctttagaag tgtaaatatc tccactatca tatccataaa ttcctgaaat tattttaaat
     4081 aaagtagttt ttccagtacc attaacaccg attataccaa ttttatcgcc ttcatttact
     4141 gtaaaactaa tattttctaa tatagaatct ataccaaaac ttttatttaa gttattacat
     4201 gacaaaacaa tcataaattt ctacctcctt gaactatcta aaattataat gttttgatat
     4261 aatataatca aggttatatg tattagtttt gaaaaagaaa tattttattg tgaatcaaac
     4321 aaaaaagagg acacttttag gaggtgaaga tgttgggaaa taaaaatata tcaatggcag
     4381 ttataagaag gctcccaaaa tatcatagat atcttggaga cttattagat agggatatac
     4441 aaagaatatc ttctaaagaa ttgagtgata taatagggtt taccgcttct caaataagac
     4501 aagatttaaa caactttggt ggatttggac aacaaggata tggttataat gtagaagctc
     4561 ttcatactga gataggtaaa attcttgggt tggatcgacc atacaacgca gttcttgtag
     4621 gagcaggtaa cttaggacaa gctatagcca attatgcagg atttagaaaa gctggattcg
     4681 agataaaagc tttatttgat gcaaatccta gaatgatagg tttaaagata agagagtttg
     4741 aagtattaga ttcagatact ttagaagact ttataaaaaa caataatata gatattgctg
     4801 tattatgtat acctaaaaat ggagcacaag aagttattaa tagagttgta aaagctggaa
     4861 tcaaaggtgt atggaatttt gcacctttag atttagaagt tccgaaaggt gttatagttg
     4921 aaaatgtaaa cttaacagaa agtttattta ccttatcgta tttaatgaaa gaaggaaagt
     4981 agacaactta aacatattaa taatgagcag ttgtaaagag tattgagaaa gtcagaagat
     5041 ttaatattaa atcctctggc tttttgaaat attaggataa aaatttaaat aatgtatgga
     5101 aataaacaat attaaggaga gtggtttttg tggaggaatt atggaaaaag gcaattgaat
     5161 ttcatggtca tgaatgtcca gggttagcta taggatttaa agcagcactt gcagcaaaaa
     5221 aatatttagg atgtaaacag tcaggagatg aggaaattgt atgtatttct gaaaatgatg
     5281 cttgtggaat agatggtata caagtagtgc taagttgcac aatgggtaag ggaaatttac
     5341 tacttaggat gactggaaaa tcagtatatc atttctttaa tagagaaaat ggaaaatcta
     5401 taaggatata tgtaaagtca aaaccatttg agatggatag agaaggatac aaaagatatt
     5461 tattagaaag tgattttgaa gaaatatttg agattacaga tactaagtta agacttcctg
     5521 aaaaagcaag aatatttaaa tcccttaaat gtgaagtgtg tggtgaattt gcatctgagc
     5581 aatatataag gattgaagaa ggaaagaaag tatgtcttga ttgttttgat aaatatgaaa
     5641 gattttatga agagtattaa aattataaat tagattaaag ttaaaagtat tagatatgtg
     5701 ctaacagtat tttaagatga attaggtagc aacataataa agtatataaa taatattaat
     5761 tgaatcatac ataattaaaa agaggctgat tagtatttat aaaataaaat cagtctcttt
     5821 atgaataacg aattattatt ctggttgagg tgcatctaca ggacaagctc ctgcacaaga
     5881 accacagtct atacaagaac cagcatctat aacatatgcg tcgtctccag ctgatataca
     5941 gctaacaggg cattcagcct cacaagcacc acagcttata caagcgtcag taattttata
     6001 tgccattttg aaatcctccc ttttatatgt attgtaattc aataacatta taacaaatat
     6061 tattgaatat aacaattaaa ttaattctac aacaaaaact ttattatgat attcttgttt
     6121 taaagtttta caataaagtt taatctgctt atatttttat ttattttaaa gaagtttatt
     6181 ttaaaaataa aattaaattt aaaaagttat gtattgatta tatttaaaaa tgttatactc
     6241 taaaaaagta tattttattt aaaaatttat taatacaaag gagatttact atgaaaaata
     6301 aattagttta catatgtatt atgagtctat tgctatttgt agtaggatgt tctaataatc
     6361 caaataagga aagtaccatt aaaaaagact ctaagaataa ccaaagccaa gttaaagaag
     6421 aaaaaagaga acctgtgaaa aaagatataa ctataagttt cgctggtgat gtaactatgg
     6481 ggaactataa aggttcatca tattatggca gttttgacca tgaatttaaa agacaaggag
     6541 aagattacaa ttattttctt aaaaatgtaa aacctgtatt tgaaaaagat gacttaacag
     6601 tggttaattt agaaggtcca cttactacag cgtcaaatgc aaaagaaaaa aaatttgcat
     6661 ttaaaggaaa gcctggatat gtaaatattt taaaatctgg aagtgtagag gcagtaagta
     6721 ttgcaaataa tcattcagaa gattattttg aagaaggaat gaaagataca cagtttatat
     6781 tggacgagaa taaaataaat tattttggat tagggaaaga tgctgttgta gatgtcaaag
     6841 gaattaaagt gggtctatta gggtataatg gattatcaac tgaatataat gaaaaaaatt
     6901 taaaacaaat ggaagatgat attaagtcct taaaaaagaa atcggatgtt gttgtagtgt
     6961 actttcattg ggggatagaa ttagattatt atccagataa aaaacaaaaa gattttgctc
     7021 attatgctat agacaaggga gcagatttag ttatggggtc tcacccacat gtgattcaag
     7081 gaatagaaaa gtataaaaat aagtatatag cttatagtct agggaatttt tgctttggag
     7141 gaaataagaa tccttctgat acagatagtt atatatatca acaaaccttt actttttcag
     7201 ataataaatt aacttcaatt aaagagccaa atataatacc aacttcaata acatctagta
     7261 actccagaaa taattatcaa ccaaaaatat tggatggaag tgagaaggat agagttttaa
     7321 ataaacttga aaaaataagc aaagatttaa ataaataaaa tgtaaaaaaa aataaatata
     7381 tatatttatt ttaataattt atattttgtt tagggtatgg taaatcgtgg tattaaataa
     7441 gtagatttta atagttaaat tatagtcaat tataataaag ctatttaatc tactttttta
     7501 atataaaaat ataaggggga atttgtaatg gcttgtaaca cttgtaaaat gtgcgaaagt
     7561 gcagacaaga aattagaaag ttttgtagct tcaaaggatg ttgaaacagc atttcataga
     7621 acagaagatc agaaagttaa gtgtggtttt ggacttcagg gggtttgttg tagactctgt
     7681 tcaaatggac catgtagagt aactcctaaa tcaccaagag gtatatgtgg agcagatgca
     7741 gacactatag tagcaagaaa ctttttaaga gcagtagcat caggagcagc ttgttattta
     7801 catgtggtag aaaatacagc taagaattta aaaaatgttg gaataactaa aggtgttgtt
     7861 aaaggagaaa aaacattaaa tcaattagca gagatgtttg gaatagaaag tgatgaaaag
     7921 tatgataaat gtataaaggt tgcagacaaa gttatcaacg atttgtataa atcaagagat
     7981 gataaaatgg aattagtaga aaaaatagct tatgcaccta gagtgaaaaa gtggaaagag
     8041 ttaggtataa tgcctggtgg tgcaaagtca gaagtttttg atgcaatagt aaaatcatca
     8101 acaaatttaa acagtgaccc agtagacatg ctagttaatt gtttgaactt aggtatatca
     8161 acaggattat atggtcttac actaactaat cttttaaatg atgttatgtt gggagaacca
     8221 gttataagaa tggctcctgt aggatttaat gtaatagacc cagactacat aaatataatg
     8281 ataacaggtc atcaacattc aacatttgca aatttccaag atagattaaa agatgaagat
     8341 gttataaaat tagctcaatc tgttggcgca aaaggattta agttagtagg atgtacatgt
     8401 gttggtcaag atttacaatt aagaggagaa cattatcaag aagtatttgc tggacatgca
     8461 ggtaacaatt ttacaagtga ggctgtttta tcaactggag caatagatat agttctttca
     8521 gaatttaact gtactatacc agggcttgaa ccaatagcag ataaatataa agtaaaaatg
     8581 gtttgtttag atgatgttgc taaaaaagcg aatgcagaat gcataggttt agacagaagt
     8641 aaattagatg aacttagtaa cactttaata gaaaaagcat tggagtctta taaggagaga
     8701 agaggaagta ttgaaataga tataccaaaa gaccatggat ttgaacaatc tttgactggt
     8761 gtaagtgaaa agaacttgaa agcgttttta ggagattcat ggaaacctct tattaattta
     8821 attgcagaag gaaaaattaa aggtgttgca gctgttgtag gatgttcaaa tatgacagca
     8881 ggaggacatg atgtaaatac tgttgaactt actaaagaat tgattaaaaa agatataata
     8941 gtactatctg caggatgttc tactggagga ttagaaaatg ttggtcttat gtcacctgga
     9001 gcagaagaat tggcaggaga aaacttaaaa gaagtatgta agactttagg aataccacca
     9061 gtattaaact ttggaccatg tctagctata ggaagactag aaatagtagc aacagaatta
     9121 gcagctgaac ttggaattga cctaccacaa ttaccattag tgctttcagc tccacaatgg
     9181 ttggaagaac aagcattagc tgatggagct tttggtcttg cccttggctt acctcttcat
     9241 ttagctttac ctccatttat aacaggagga aaattggtaa cagaagtatt aacagaaaaa
     9301 ttaaaagact taacaggagg acatgttata gtgaatccag accctaaatc ttcagctaat
     9361 caattagaag aaataataat agatagaaga aaaaatttag ggttaaagga tgtggaatgc
     9421 aatgcataga atttttataa ataaagattt atgtacagga tgtaagagct gtgtactagc
     9481 atgtatgcta aaacacaata aagattatga catgtacact cttgatttag aaaatataga
     9541 taatgatagt agagggcata tagaattaga tagtagacat aataatccag ttccaattct
     9601 ttgtagacac tgtgatgaac ctgaatgtgt attagcatgt atgagtggtg caatgcataa
     9661 agatagtgaa agtggaatcg tttcatatga tgaagagaaa tgtggttcat gttatatgtg
     9721 tgtaatgtct tgtccatatg gattattaaa gccagatgat agaagcaagc agaacatact
     9781 taaatgtgat ttatgtaaag atgaggagta tcctagatgt gtagctaatt gcccaagtgg
     9841 agcaattgaa ttacagaagg aggaaaatga tgaattatgt agtgttaggg gctagtgcag
     9901 ctggtataaa tgcagtaaaa acattaagag aattagataa agattcaaat atagtagtaa
     9961 tttctaaaga tgaaaacgta tattcaagat gtatgttgca tcacgttata tctgaacaca
    10021 gaactttaaa acaaataaat tttgttgatg aagattttat ggagcaaaat aatgtaaaat
    10081 ggattgcagg taagactgtt aaaggtatag acataaataa aaaggtagtt cagacagaag
    10141 acattactgt aaattatgat aaacttttaa tagctacagg tgcatcttct gctattcctc
    10201 ctataaaaaa tttaagagat ggaaattttg tatattctgt gagaaacata gatgatattt
    10261 ataaaataaa agaaaaagca caaaattcta aaaatgtagt tataataggt gctggtttag
    10321 ttggtataga tgcattagtg ggattattta aatatgagca gttaaatatt tctgtagctt
    10381 ttatggaaaa gtacatttta gatagacaat tggatgaata tacagcatca gtgtatgaaa
    10441 ataagttcaa agaaaaaggt gtaaaatttt acccaagtgc atcaatacaa gaaattgtat
    10501 tggataacag taaaaatgtt acaggtgttg cattttcaaa tggtgaagtt ttagatgcag
    10561 acatggtaat tgtagctaca ggggttaaac caaatgctga ctttttagat ggaacaggaa
    10621 tagaatatga tagaggtata ataatagatg atatgtgcca aacaacacaa aaagacatat
    10681 atgcagcagg agatgttgta ggtaaaaatg ctatttggcc tctggcagta aagcaaggaa
    10741 ttgtagctgc ctataatatg gttggaaaag ataagaagat agaagatgaa tttgctttta
    10801 aaaatagtat gaatttcatg gatataccaa ctatttctat aggaatgaat acacctgtag
    10861 atgatagcta taaagtatta accagacatg gaattaatga ttataaaaag tttgttttta
    10921 aagataatgt aatctatgga gcagttatac aaggagatat ttcatatgta ggtgtattaa
    10981 cttatttaat aaaaaataaa gttgaaatat atgatttaga aaataggata tttgatatat
    11041 gttatgcaga cttttttaat ataaaagaaa atggagaatt ttgttatagt gtatagtata
    11101 tacgtggagt aaggtttata aatacagtaa atcaataaat agagttattc taaaataaga
    11161 aaaatgacaa atcttattta gaaatagctc tattttttgt aattaaattt aaattatatt
    11221 caatttgtaa aatattattt tgaacaatta tacatatact ctctagttag aggtaaatca
    11281 ttttttatac ctttagtgaa aagtatttga tgtatatcta taataccagt gttgaaagca
    11341 gcagcacaag aacaaaggta taaatcccac attcttataa acttatcatc aaacatttct
    11401 ttaatctttg gaagattctc agagaaattt ttttgccagt atagtaaggt ttttacataa
    11461 tgtaatctta aactttctac gtctatagta tgatatttgt aatcactaca aatatgtatc
    11521 atttctctta ggctaggaat aactcctcct gggaaaatat atttttttat ccaagggtct
    11581 ccataagatt cctgcaatcc acttatatag tgaagtaaaa acaatccacc atcttttaaa
    11641 acagcattta cgtttttaat gaaaagttca tagttttctc taccaacatg ttcaagcatc
    11701 ccaacgctta caactctatc aaacataagg tctgattttt ttaattctct atagtccata
    11761 agtcttacct caagatagtc ttgaaggttc tcttctttaa ttcttgcgtt aaattcctta
    11821 aattgctctt cgctaagtgt aattccaacg ccgtgaattt tatatttttt tgcagcttct
    11881 attagtaaaa atccccaacc acaaccaata tcgagaaggc tcataccttc ctctaaattt
    11941 agtttagtta atatgtggtg aactttattg acttgagcat cataaagagt atcattatca
    12001 tttctaaagt atgcacaaga ataactaagt gtcttatcta accataagct ataaaaatcg
    12061 ttgccaatgt catagtgggc atgtatttct ttcttttgat gtctcattga atttgatgag
    12121 tgcaatagat gttttacagc tgaattatca atattgaatt tgtctatttg ttttaaaagt
    12181 agatttaaag ttaagaataa atctccctca acttcaatgt ctctatttat gtaggcttct
    12241 ccaagtgcta aagatgtact ttttaatagt tcagacttgc taatatcatt atttactata
    12301 actttgaact gaggggagcc ctctccaatt agaaattctt cctcatcttt aagcctaact
    12361 agaaatggtg tttcaccaaa tttctctaaa tagtctttta aaaaattttt tgtaatattc
    12421 atattaccag ctccttctaa tgtaaatcca gtaagtttcc ctgcttaaaa tatattatag
    12481 tccttttttt aaaaaagtaa aattttttca ataaattttt tatttaaagg aaatttattt
    12541 tttgtaaaga aatttcatgt tgtagtatat tttttgctta taaattttgg tactggatat
    12601 aatattaaac tgttaatgat ataataaatt taatctataa agtaaataaa attttgtaat
    12661 aaatagttaa agctatttta taaggagata tatgatggaa gtatatgctt tggttgggtc
    12721 aagtggcaca gggaagagct ttaaggcttt agagttcgca tatgaaaatg atatagaata
    12781 tataattgat gatgggattt taatatacaa aaacaaggtt ttagctggga tatcggcaaa
    12841 acaagcaaat actactatag aagcagttaa aagggctatt ttttataatc tggagcatag
    12901 acaagaagtt agagaagcaa ttaaaaaaga aaatataaga aaaattctta ttattgggac
    12961 atcaaaaaaa atggttaatc aaattgtaga gagattgtca attggaaggg tttgcaagtt
    13021 tataaatata caagatataa gtactaaata tgaaatagaa atagcaaaac aagctagaaa
    13081 agaaggaaat catgtaattc ctgttccagc agttgagata aaaagtatgg caagtggtct
    13141 tagtataaat tctttgaaga gactttttag aaaaggaaat aataggaata tggtagtttt
    13201 agaaaaaaca attataagac caacttttag ttatatagga aagttttata ttagtgctga
    13261 tgtaattaaa cagattattg aatatgaagt atacaacttt ggaagcattg atagaataaa
    13321 taaaatcaat atagagaatt gcaataattt tatgaatatt tttgtaagta taaatatcaa
    13381 tgatttagaa actataaaaa aaattgaaga catacaacag acaataaaaa agtctattga
    13441 gaaaatgact ttagttaatg tacaaaaaat agatattaac attcataaaa ttaaaaaaat
    13501 aaacttcctc caatgttaaa aaataaactg agaaaatgat atactaattt gcaataaagt
    13561 gtgctataat taaactgtaa atttaggaaa tggttttttc taaatggagt atacataatt
    13621 ataacgtatt tataaggggg ctttcaaatg tcaggaaaag atgtaaatgt cttcgagatg
    13681 gcgcaatctc aagtaaaaaa tgcatgtgat aaattaggta tggaaccagc agtttatgaa
    13741 ttattaaaag aacctatgag agttatagag gtttcaattc cagtaaaaat ggatgatggt
    13801 tctataaaaa cttttaaagg atttagatca caacataatg atgcagtagg gccaacaaaa
    13861 ggtggaataa gattccatca aaatgtttca agagacgaag taaaagcttt atctatatgg
    13921 atgactttca agtgttctgt aacaggtata ccatatggtg gaggtaaagg tggaataata
    13981 gtagatccat caactttatc tcaaggtgaa ttagaaagat taagtagagg atacatagat
    14041 ggaatatata aattaatagg tgagaaagtt gacgttcctg caccagacgt aaatactaat
    14101 ggtcaaataa tgtcttggat ggttgatgag tacaataaat taactggaca aagttctata
    14161 ggtgttataa ctggtaagcc agttgaattt ggtggttctt taggaagaac agctgctact
    14221 ggatttggtg ttgctgttac tgcaagagaa gctgctgcta aattaggaat agatatgaaa
    14281 aaagctaaaa tagctgttca aggtatagga aacgttggtt cttatacagt tcttaactgt
    14341 gaaaaacttg gtggtactgt tgtagctatg gctgaatggt gtaaatcaga aggttcttat
    14401 gctatataca atgaaaatgg tttagatggt caagctatgt tagattatat gaaagaacat
    14461 ggtaacttat taaacttccc aggagctaag agaatatctt tagaagagtt ctgggcttca
    14521 gatgttgata tagtaatacc agctgcatta gaaaactcta taactaaaga agttgctgaa
    14581 tctataaaag ctaaattagt ttgtgaggct gctaatggac caactactcc agaggctgat
    14641 gaagtatttg ctgaaagagg aatagttctt actccagata tattaactaa tgctggtgga
    14701 gttacagttt cttacttcga gtgggtacaa aacttatatg gatactactg gtcagaagaa
    14761 gaagtagagc aaaaagaaga aatagctatg gttaaagcat ttgaatctat ttggaaaatc
    14821 aaagaagagt acaatgttac aatgagagaa gctgcttaca tgcattcaat taagaaagtt
    14881 gctgaagcta tgaaattaag aggatggtac taagatttac tcttaataaa taataggata
    14941 taattattta agatataaag gggctgtaca tagtacagcc cttaaattat gtggcttaca
    15001 atgaagtaag ctatttttgt tttaacttat aaataacttg ataaattatg taatttagaa
    15061 tgtatttttt accaccacat gattacaaat tagaggagtt agattgaatt tttagacatg
    15121 aacttatgca ttttaaaagc aaagacctta atttaaagta tctagtatta tttttaaaaa
    15181 tagtatattg gtttaatcca tttatatgta taatggaaaa atatatggat ttggattgtg
    15241 aattttattg tgatgagaga gttttaaaaa attgtactgt acaacaaaag caagaatatg
    15301 ctctaactat tgtaaattca atgaaaagag gtacaaattt ttcaaataaa tttgtagctg
    15361 gattaaataa acaatctgat attataaaaa gagtaatgaa catgttcagt gaaaaacata
    15421 aaaatggtat cttaatggct ttgattataa gcttgttttc ttctattaca ttttttaaat
    15481 tcgattcaac tagtattatt gaagagaatg atttcttaga gaggttaaga tatacgtttg
    15541 aaggaaggca agaagatatg tttgtaacaa tagattttac atatgcagat acacctataa
    15601 aacttagaaa agagcatgaa gaaaactgta gagtcaatgg aatagtacca aaagattcag
    15661 attcaataga aattattcct agattttata aagattgtat ggatttaaaa aaataagtta
    15721 gacttaatat tgatgttgat attatgaatt ttttatattt aagcaattga aaattttatt
    15781 atagattcaa ttttatatgt gtttaagtat gaaatttata gatagttgaa ataattaaat
    15841 atgattgatg cataggaatc attactaagc tataattaat tataggggag tttaaataaa
    15901 ttatgagtta cacaattata aaatgataaa aatagttatc tgttacaaaa aatgtatctt
    15961 tttaattaat aaagataata tgaaaactta aaaggcaaat aaacttaaat ataaaatact
    16021 cttaaataag ataggagaaa aatgtatgtc taactttatt ctaaatggga tttttagaac
    16081 agttatagta agtagtctaa gcattcttct gatattgatt ttcaagaaaa atgtatttaa
    16141 aagatttagc aaaaaattta attattatat atggatgata gttgttatta aattattttt
    16201 accatttaca tattatactt ttacaataaa tatcttgaga agtaaaaaac acattaatat
    16261 taataacata aatttagagg gatttaataa tgtttcaact ataagtaata atattatatt
    16321 gtacacttgg attataactg tagtagtgta tttaatttac actatattta aatatataaa
    16381 acttaaaaat ttaataaatg acttatctta tgatgttgat gatagagaga ttgtaaatct
    16441 ttataaaaat atattagaag aatttaatat aacaaaagat ataaaactca aatactctta
    16501 tgaagttgaa acaccagcat tttttaattc atgtgtactt ttgccaccac atgagtataa
    16561 attgaaagag ttagactgga tttttagaca tgagcttatg cattttaaga gtagggacct
    16621 ttatttaaaa tatgtaatcc tgtttttaaa aacagtatat tggtttaatc catttatata
    16681 tataatggat aaacatatag atttagattg tgaactttat tgtgatgaaa gagttttaaa
    16741 aaatcgaaat tcagaggaaa aaaaggatta tgctttaaca attctaaatg caatgagaaa
    16801 aggttcaaat acttcaaata aatttatagc tggactccat aagcaatctg atattaaaaa
    16861 gagagttatg aatatgttta atgaaaagta taagaatggt atattaatgg cattaacttt
    16921 atgtttatta tcttctatta cttttttgaa ggttaattca actagtattg ttaatcttaa
    16981 tgtattacct aaaggatttg aagacttacg aactgttagc agtatacgtt tttcagttat
    17041 aggatttaca tatgcagatg ctcctaaaaa tatgagggaa gaatataaaa taaattgtga
    17101 atcattaggt ttgataccta aagactctga taaaatagaa gttggtatag aatattatga
    17161 cagtctattg aatgattaaa taaatattat tttaacagat attaattata aagttttgaa
    17221 tagtaatttg ttgagaaata aatatatcct tataaaaata gatacttata taccaagaat
    17281 aaaaaatagt caagatagta cacaaggata tacttataaa gaacttaaat aagtgaaata
    17341 aattattaat tataaggttt ataattttaa aaaattagat aaattcaggt gtaaaatact
    17401 ataaaacaca attcggaaaa gtgtatgttg aacttcattt aaaatggaat ttcaaagttg
    17461 ctatagtaag tagtttaagc attcttctta tattaatctt tgagaataat gtatttaaaa
    17521 aagttagtaa aaaatttaac tattgtatat taatgatagt tgctattgat atattatcta
    17581 aaaaaattaa gtatgaaaag attactgcta ggacaatctt ttcatactta atttttaata
    17641 tttatattat ccaaaatttt catcttttta acttagaatt tgagaatcac tattaggaaa
    17701 taggctttga tttatgtagg gttaaaaatt tcacagcata tctaacttta tactaaatcc
    17761 atcaaaaaat atacgcccta taaaagcgca taaaaaaaca cataaaacaa tatttatgcg
    17821 cactttaacc tcgaatggta caaaattctt tacttttaca gacccatatt atataattaa
    17881 gtaaataatg tatatttagg tgacatattg gataagctaa tttatttatt ttattaatat
    17941 aatgatacta taaaagttat ataaagtggt ttacaaaaaa gttacagata gagcttttat
    18001 taatgtattg tgtattagta ttttatcctt aggtacactt cacctacaaa atagaatcat
    18061 aagataatta tgggaaaatt ttaggaggtt tatcgtgaag aaaaagatat taataccagt
    18121 atttgcatca gttatggcat tatcagtaag ttcaattgta aatgcagatg aagtaaatga
    18181 ttcatctcaa aataaggatg ataaaacaaa tactgaatta aatttaggtg aatataaaga
    18241 agtaaaatat aaagttgcaa aaataaaaga tggagtagct ataaagataa gagaagaagg
    18301 tcaagttcaa aacatagctt attctggaga tgaatttacg gttttaggaa ctcaaggaga
    18361 atgggttaag gttaaagttg aagatggcga aggttggtta gctactagat atgtagatat
    18421 atctgaaggt gtaggatata ctaacgctga taaagtaaac ttaagaaaag ataagagtga
    18481 aagttcagaa gtaattgaag agctggaaaa aggaagttct ttattggttt tggaagataa
    18541 tggagattgg ttaaaagtta aagatgggga aacagaagga tatgtaaaat catcttatat
    18601 atctgataaa gctcctgtaa tagaagagcc acaagtaaac ccaagtattg accaaaatgt
    18661 agattctaca aataataatc aacaaaacaa tgcaaatact aatcaacaaa ataataattc
    18721 aaatgtgcca acagctaact ctaatgcagt tcaagctgta cttaacttgg catattctaa
    18781 gcaaggttgt ccatatgttt ggggagcaga aggaccaaac acttttgact gttctggatt
    18841 tacacaatat gtgtatagaa atgcagtagg aaagaatata ccaagaacat ctaaagcaca
    18901 atctaaatat ggacaaactg taagtaaagc aaatttacaa ccaggagact tagtattctt
    18961 cacaactaat ggttctggtt ctgttagtca tgttggaata tatgtaggtg ggggtaatat
    19021 gatacattca ccatcaacag gaaaaacagt tagtgtaact agtataaatt catcatacta
    19081 tacagcaaga tttgttacag caaaaagaat attataatcg gtttgtaata tgacaaattg
    19141 ataaatacat aaatatatat aaacgctcta tattatattt aatttaatca tggaaacaaa
    19201 aaatgattat attttaaatg tactatagag cgtttttgta tcactttaaa tctaatcaag
    19261 attcaagtta atatgactgt taaataggag ccttttcata tgatgattat ttgtgcaatc
    19321 ccttgacagg atagggcaaa ggtggtaagc tactaacagt acaaaaatac ttttaatttt
    19381 agttcagaga ggctaaaaaa ggaggacgaa agatgttaaa atcaagaaat ttaatccaac
    19441 cagaagactt ttcaatagaa gaaatagatg aaatattaga attagctcaa aaaataattg
    19501 acaatccgtc aaaatattct cgtatatgtg aaggaaaact attagctaca ttattttatg
    19561 aaccatcaac aagaacaaga ttaagctttg aatctgctat gaacagatta ggaggacgtg
    19621 tagtaggctt ttcagagcca aattcatcct ctgcatcaaa aggtgaaact ctaggagata
    19681 caatgaggat agtatctggt tatgttgata taatagctat gagacatcct caatcaggtg
    19741 cagcttcaga agcagctaga tatacggaag tgccatttat aaatgcagga gacggcaaga
    19801 accagcatcc aactcaaaca cttacagact tacttactat aaaatcatta aaaggaactt
    19861 tagaaagcca tacaatagga ttatgtggtg atttaaaata tggaagaact gtgcattctt
    19921 tagttaaggc tatggcaaga tataaaaata caaagtttgt atttatagcg cctgaagagt
    19981 taaaaatgcc agattatata aaagaagcta taaagggaca tgcatattat gaaactaata
    20041 atttggatga tgttatagga agcttggatg ttttatatat gactagagtt caacaagaaa
    20101 gatttgaaga taaatcagag tatgaaagac ttaaaaacta ttatatttta aataaagcta
    20161 aattagaaaa ggcatctaaa gatatgttag taatgcatcc attaccaaga gtaaatgaaa
    20221 tagacataga tgtagatagt gatgatagag ctgtatattt taaacaagct aaatatggaa
    20281 tgtatgttag aatggcttta ataataaaac ttttaggtat aaatgaagac taatagttat
    20341 catataatag taaaacaaag gagattttgg gatgtataaa attctggaaa atatatatat
    20401 aggcgaagat atgtatagaa tgaaagtaaa aggtaatttt gaaggtaaaa tgggacaatt
    20461 ctatatgtta agagcatggg atacttatcc agtactttca agacctataa gtatacatga
    20521 tatagatgaa gaagggataa cttttcttta taaagtagta ggagaaggaa ctcaaatttt
    20581 gagtaaccta aaggtaaatg ataatataaa attggaaggc ccttatggta atggatatgc
    20641 taaggttgat ggaaaggtag ctctagtagg aggaggaatc ggtgtagctc cactatattt
    20701 ggttgctaaa aatataaaaa attgtgatgc atatcttggg tttagagaag atgttatatt
    20761 agaagatgaa tataaacaag tatgtaataa agtctataca acagtaggaa atacttttgt
    20821 aacagatata attgatgttg agaaatatga ttatatatta acatgtggtc caactccaat
    20881 gatggaaaaa ttagttaaga tggtagaagg tactaaaacg agaattatgg tatctcttga
    20941 aaaccatatg gcttgtggag taggtgcctg tttagtatgt acgtgtaaaa ctaatggagg
    21001 aaataaaaag acttgtaaag atggtccagt gttctgggga gaggacgtga tttttaatgg
    21061 gtaatttaag tgtgaaattt ggaagtgtag aatttaaaaa tccagtaata atggcgtctg
    21121 gaacttttgg atttggaaaa gaatataatg agatttatga tatacaaaaa cttggtggta
    21181 taagtagcaa gggtcttact ttaaataaaa aacctggtaa caatggtatg agagttcatg
    21241 agacaccatc cggtatgatg aatagtgttg ggcttgaaaa ccctggagtt caaggattta
    21301 tagactatga attacctttt tttagtaaac tagacttagt cagaatagct aatgttggag
    21361 gtgggacatt agaagactac ttattagggg ttcaaatgtt aaatgacaag cctatagaca
    21421 ttattgaatt aaatatatct tgcccaaatg tcaaagctgg tggaatggct tttggtataa
    21481 aaaatgaagt ggcaagagaa gttgttcgtg aggtaagaaa cataacgaaa ctgcctttag
    21541 taataaaatt atcacccaat gcagaagata ttgtaggaat ggcaaaagtt tgtgaagaag
    21601 aaggtgctga tggagtttca ttagttaata cttttaaagc aatggcaatt gatataaaaa
    21661 atagaagacc agtatttgaa aatgtatatg ctgggttatc tggaccagct ataaaaccta
    21721 tagctttgag aatggtacat gaagtgtgta aaaatgtaaa tatacctgta atgggaatgg
    21781 gcggaataac taaagccaca gatgctatag agtttataat ggcaggagct acttgtatcc
    21841 aagttggaac tgcaaatttt atgaatccta gaataggtat tgaaataata gatggaatta
    21901 atgaatttat ggatagagaa ggaataaaaa gtttagacga aataagagga attatataag
    21961 gtagaataaa tagtatttta aagataaaaa atatagatta aataaacaat aattttataa
    22021 cattaacatg gaggaaaaat aatatgagta aagtagatgt agtggatata ttaaagaaaa
    22081 gtgatgcatt gttggaggga cattttttat tatcttcagg aaaacacagt aatagatacg
    22141 tacaatgtgc aaaagtatta agatttccag aatatgctgc tgaggtatta agtacagttg
    22201 ttgaacaaat aaaagactta gatatagact tagtagtagg accagctatg ggtggagtaa
    22261 tagtttctta tgagttagga agacaattag gaaaagaagc tgtatttact gagagaaaag
    22321 acaatacaat ggagttaaga agaggatttg aagttaaaaa aggagcaaag ataataattg
    22381 ctgaagacgt tgtaactact ggtaaatcaa ctatggagac aaaaagagta ttagaagcct
    22441 taggtggaga agttgtaggt gttgcatgta tagcagatag aactaatcat gatataggta
    22501 tgcctatata tagtgctata aaacttgata ttcaagttta tgaatctgat gagtgtcctt
    22561 tatgtaagga aggaaaatta ccagttgtta agcctggaag tagggagttc aaggaattag
    22621 ggatgtaata aaaacttaat tatttatagt gttacttaaa aaatgtaaat tttttagagt
    22681 aaaaacacaa taaaaatctg attatccgct aaaacacagt atctatcagc attttcaagg
    22741 aaacaaacac atcaatttac tacttattta ctactaacga atgagccttg atacgcaagt
    22801 tttcctagat atgcaaagat atggtacagc acatcagtat tgaaacaaga aaaaattgaa
    22861 taacttatag actatggaac gcctaaaatg acgttccttt tctatttcca gccgttctta
    22921 ttggacggct attttattac ccaaaatgaa aggagcatta gatttatgaa aaagacatgg
    22981 aaacgattgt gtacgggctt cttagctctt gcaactgtcg ttactgcttt accgactaca
    23041 cccgttcatg cagaaagtaa gcaatactgg acggagtcaa acgagcgtgt cggtatcgtt
    23101 gaaaaagtaa tgaatgacgg ttcgattggt tctaccttta atgagggaca tttaactgtt
    23161 gagggcgagg acgcttactg tattgacatt aacacagact ttaagaatgg ttacaagacc
    23221 agagctgacg caagctcacg catgagtatc gaccagataa gcgacgttgc cttatctatc
    23281 gaatatgtaa aacagtacac agacagccac agcggaatag gcaaaaatca cgcttacctt
    23341 ttaagacagc ttgtagtctg gcagagatta agcgtacatc ttggctggca atgtgataac
    23401 gtgcgagctt cttatgatga aattccaaag gcaacgcagg acgaagtttt cgctggtgcg
    23461 aaagcctttg tcaaagaaaa taaaggacgc tatgaatgtg gcggttatat ctactctggc
    23521 gaggggcagg aattgggaca attctgggcg aagctgaatg tcggaaatgc gaaactgcaa
    23581 aagacttcca gtaataccag cattacagac agtaacggga attactctat tgcaggtgca
    23641 acctatggtg tcttttctga taaggactgc acgaaacagc ttgccaccct tacgactgat
    23701 gaaaacggca atacagatgt tgcagaggta aaagctggca cagtctatat caaggaatta
    23761 tccgcaccag caggatataa agtagataaa actgtatatt ccttaaaggt tgaagctgga
    23821 aagacagcta ccttgaaagt atcagataca ccgaaagtaa cagacacttt gattgagctt
    23881 ttcaagattg atatggaaac acagaaagac aatccgcaag ggaacgcttc tttagcaggt
    23941 gcggaattta catggaagta ttatgctggc ttctacaata aagaaaatct tcctgccgaa
    24001 gctactcgta catgggttac aaagacaatc gctgaaacag acagcgacgg gacaactcat
    24061 tacatcacaa aattagcgga cgcatacaag atatctggcg acagcttcta tatgcaggac
    24121 ggtaaggcgg ttcttccact tgggacactt actgttgagg aaacaaaagc tccaaacggc
    24181 tacttgttag acggtgcata tatgcaggct ggcgataagc ccgaacagat taagggctta
    24241 tatgtaacac agattaccga ggacggcgac cttgccgtac tatctggaag taaccagttt
    24301 tccgtatcag acaaggttat ccgtggcggt gtgaaaattc agaaacgaga tttagaaacg
    24361 ggcgatacga aaccacaagg aagtgctacc ttgaaagata ctgcctttga catcatttcc
    24421 ttaaatgata atgcggtatt ggttgagggc aagctataca agaaaaatga agtgctaaaa
    24481 acaatccata cagacattga gggtgtcgct tctacttccg ctgacctttt accttatgga
    24541 aaattccgta tcgttgagag tgaagctcca gacggttact tgacagacgg tgcgaaaccg
    24601 attgattttg caatcacaga aaatggaaaa atcgtggact taacagacga agcccattct
    24661 atctataatc agattaagcg tggagatatt gagggtataa aaataggtgc gggcacacat
    24721 aagcgtcttg ctgatgttcc ttttaggatc acaagcaaga caacgggcga aagtcatgtt
    24781 gtggtaactg atgataacgg tcagttctcc acttctgctg actgggcttc tcataagcac
    24841 aataccaacg caggaaaaac aagcgaggac ggcgtgtggt ttggaacttc tgaaccagac
    24901 gacagcaaag gtgcgttacc ttacgatact tacatcattg aagaaatgcg ttgcaacagt
    24961 aacaaaggct ttgaacttat cccacctttt gaaatcgtgg tatcaagaaa taatcttgtg
    25021 attgatttag ggactttgac tgatgaatac gaaaaagaaa tctctatcca taccacagcg
    25081 accagcaagg acggcgaaaa gactatcctt gcaggaaaag aggttacaat cgttgatact
    25141 gtcaaattag acggacttac aaaaggcaca aaatatcagc tcaaaggctg gcagatgtta
    25201 aaggaagaaa acgcagaact tcttattgac gggaaacgtg tagaaaacga ttataccttt
    25261 gtcgctgatg atgaagaaat gaaagtggaa atttcctata tattcaatgc gtctgcttta
    25321 ggtggcaaga accttgttac ctttgaagaa ttgtatgatt tcagcaatcc agacgaaccc
    25381 gtaaaagttg cggaacacaa ggacattgag gacgacgggc aaaccgtact tatcacagag
    25441 cgtatcatca aaattcatac gactgctacg gataaggacg gcaacaaaga gcttgaagct
    25501 ggaaaagagg taacaatcat tgataccgta accttagagg gcttagaagt cggtacacag
    25561 tacaaacttg tgggctggca gatgttgaaa gaagaaaatg cagaacttct tatcaatgga
    25621 aagcgtgtgg aaagtgatta tacttttact gctgacagcg aaactatgaa agtggaagtt
    25681 gcttttacgt ttgacgctac ttctcttgac ggcaaacagc ttgtaacttt tgaagaattg
    25741 tacgatttaa gcaatccaga cgaaccgaag aaagttaccg agcataagga tattgaggat
    25801 aagggacaga cgattacctt taaggaaaag ccagaagaac cagagaaacc cgaaacacca
    25861 ccgacaccag aaaagcctaa cagacctagc gacagtccca aaacgggcga cagtacaaat
    25921 gtaatggcat ttgtcgtgat gttgcttgcg tctgctggtg gactggctgg aacatatctt
    25981 tacaaacgcc gtaaaatgaa gaaatcgtaa ggcggtaacg gtatgatgaa agaaaaatca
    26041 cgctctccgc cgaagctgtc aaacggcaga cttccgctta ttctggcttg tctgcctaca
    26101 acctgcaaga acacggatag tcaagggtgc gtaagcattg attttaccct ttactatctg
    26161 ggggattgct ggtacttccc aaaccgccag aataagaaat cacaatcaaa aaacttatca
    26221 aaaataaaaa gaaacgaggt aaaacaatat ggaaatgaaa tatgtcgtgc cagatatggc
    26281 acagtctttt ggaacacttg aatttgcagg cgaaagcgag ccagtctttg aaagagataa
    26341 aaataaccgc agggtcttag ccagacgaag ctataacctt tattctgacg tacagaaagg
    26401 cgaaaatgtt gtcgtggaaa ttcccgtgca ggctggcgaa aagcatttca agtatgaaca
    26461 gaaagtaaaa cttgtcaatc cgaagttata cggcagaggt tatgcaatcg gggatatggg
    26521 acataccgat tatgtgttag ttgctgatga tattgtagca gttgaagaaa agtaaaggag
    26581 tgaagaattt atgagattat caaacgggtt tgttattgac aaagagaaaa catttggaga
    26641 attaaaattt acagcggtgc gtgatgtgtt cttgcagaac gaggacggaa caccgagtac
    26701 ccagcttaaa aagcgtatct atgatttgaa gtgcagtctg catggtggaa ttatccccgt
    26761 gtctgtaccg ccagaagtac cgttaagaga atttccgtac aatgcagtcg tggagcttgt
    26821 caatcccgta gcagatacgg tatcaagaaa gacgtttggt ggtgcagatg tggactggta
    26881 tgtaagggca gaggatattg tgttgaagaa taaaggcaac cagaacgcag gcaatccaca
    26941 gaataataac acgcagggac agccgaaaaa acaaaattag agattagatt tttattgtga
    27001 ggtaattcgt tgaatgatat aattaggata aattgtgagg tgcttatcta tgaaagtatt
    27061 agttagttca tgtatcatgg gaaaaaactg caaatataac ggtgggaata atctcaatcc
    27121 gaaagttgta gagtttctaa aagacaaaga ggttatcgaa atttgtccag aattattagc
    27181 gaatatgcct acaccacgtc ctagtgcgga aatagtaaat ggtattgtca tggatataaa
    27241 tggaaatatt gttgatgagg aatatcgtca tgcggtacag ttggctctaa atgaaataag
    27301 aagtatggaa atagatttag ttattctgca atcaagaagc ccaacttgtg cagtcaagaa
    27361 tatttatgat ggtagtttta cgggaaaatt gataaaaggt caaggtctgt ttgcacaagc
    27421 gttaattgag gctggatata aagtgttgga ctcagaagat ttttaatgaa tggtaatgaa
    27481 aaggcagtta gtcttaggat tgactgcttt tttcataccc agaaaggagt gattgattta
    27541 tgcaaaagat ttggaataaa ggacaccgta tcagagccag cgacaagcac cttgtctacc
    27601 acttttccat agggacgctt ctgtttgtat ttgtgacggt tcttttgcta ctgaatatca
    27661 aacagctcat gtgtaccgat tgggaacatt tcagtttgtt agagaacggc ttgacgctct
    27721 ccccttacaa cttcataacc atactgatag cgactggtgt ttgtgcattg gtcgcttttc
    27781 tgtattaccg cttctgttac gacaatttca agaagctcct gcaccgtcaa aagctggcaa
    27841 gaatgatact ggaaaataag tggtatgaag ctgataccgt gcaagacagc ggttttttta
    27901 ctgacctgca aagcagatca agagaaaaaa tcgtctggtt tccaaagatt tattatcaaa
    27961 tggaaaaagg actgcttcat atccgctgtg aaatcacgct ggggaaatat caagaccagc
    28021 ttttacggtt agaggataaa ttggaaagtg gcttatattg cgagctgacc gacaagaccc
    28081 tgcatgacgg ctatatcgaa tataccctgc tttatgatat gatagcgaac cgtattacca
    28141 ttgatgaagt acgagcagaa aacggctgtc ttagactgat gaaaaatctt gtctgggaat
    28201 atgacgcact tcctcatgct ctgattgctg gtgggactgg tggcggtaaa acttattttc
    28261 tgctgacact cattgaagcc ttactgcata ccaacgctgt tctttacatc ttagacccga
    28321 agaacgctga ccttgcggac ttagggacag ttatgggaaa tgtatatcac accaaagaag
    28381 aaatgataga ttgcgtcaat gccttttatg agggtatggt acagcgaagt gaggaaatga
    28441 agcgacaccc gaactataag acgggcgaaa actacgccta tctgggactt cccccctgct
    28501 ttcttatctt tgatgaatat gtggcgtttt ttgaaatgct ggggacaaaa gaaagcgtga
    28561 gcctacttag ccagttaaag aaaatcgtta tgttagggcg acaagcaggt tatttcctta
    28621 tcgtcgcctg ccagcgtcca gacgcaaagt atttctcgga cggtatcaga gataacttta
    28681 atttccgtgt gggattgggg cgtatcagcg aattaggtta cggtatgctg ttcggttcag
    28741 atgtaaaaaa gcagtttttt cagaagcgta tcaaggggcg tggctattgt gatgtgggga
    28801 caagcgttat cagtgagttt tacacgcctt tagtcccgaa aggacatgat tttttgcaga
    28861 ctatcggctc tcttgcacaa gcaaggcagg acgggacggc gacgtgcgaa gcgaaaggcg
    28921 acggcacgga ctagccgttg ctggtgtggc gttagccacg ccagcaggta aaacccctcg
    28981 gtatctaaca gaggggtacg tttgcaaata gacaatagac aaaaaacata ggaaacataa
    29041 ggcttctgat atggttttct agtaaaaatc agttgtgaag tcgccttaaa aaacttcaca
    29101 ctttacagat tgggggtatg gttctgaatg aagaacaatg gataaaagaa ttacgggaga
    29161 aacggattgc ttacggtatc tcacaaggca ggctggcggt ggtttctggt atcacaagag
    29221 aatatcttaa caagatagaa agcggaaaaa tgaagccgtc aaaagaactt ctggaaactt
    29281 tgaataagga actggcaagg ttcaatccag aagcaccgct taccatgctg tttgattatg
    29341 tgaaaattcg ttttcccacg ctggatatac agcacatcat caaagatata ttaaaactga
    29401 atatcaatta tatgctccat gaagattacg gacattacag ttatacggag cattattctt
    29461 taggggacat ctttatctat acgtcggctg acgaagaaaa aggtgtcctt ttagaattaa
    29521 aggggcgtgg ttgcaggcag tttgaaagtt acctgctggc acagcaaaga agctggtatg
    29581 acttcctcat ggacgcactc atagacggtg gcgtgatgaa gcgtattgac cttgctatca
    29641 acgaccatac gggcattttg gatattccag agcttgcgga aaaatgcagg aaacgggaat
    29701 atatcggaaa gtccagaagc tataagtttt atcagtcggg cgagcttatc aagcacagag
    29761 aggacgacag agaatatatg ggacgtaccc tttatcttgg ttcgctgaaa tcagatgtgt
    29821 atttctgtat ctatgaaaag gactatgagc agtatgtcaa gttagggaca ccacttgatg
    29881 aagccgacat tatcaaccgt tttgagatac ggcttcgcaa tgaacgtgct tactatgcag
    29941 tacgagattt gctgacctat tatgacgcag agcagaccgc cttttctatc atcaaccagt
    30001 atgtgcggtt tgttgatgaa gaaccagaca agcgaaaaaa tgactggaaa ctcaatgacc
    30061 gctgggcttg gtttatcggc gataacagac agagtttgaa gctgacgaca aagccagagc
    30121 cttatacctt agaccgcaca ttgcggtggg tacaaaggca ggtagcaccg accttgaaaa
    30181 tgctgaaaaa gattgataaa ggaaacggta cagattacat ggaaacaatc gaacagcagg
    30241 caaagctcac agaaaagcat gaaatgataa tcaaacagca gacgacccct gcaaaagatt
    30301 tagtagaaag ttaggagtga taaaaaatgt gggtattatt aaaagacttc ctgctggtat
    30361 ctatgggaat gggtatcggc gtagtcttga tgtgtatttt gaatgtcggc aaagaagctg
    30421 actgtgaaat gaaacaatta aaagaaagtg aggacaatta aatgaatttc ggacaaaatt
    30481 tatatcaatg gtttttatca aacgcacaga gcttagtgct tatggcaatc gtggttatcg
    30541 gtatctactt agggttcaag cgtgagtttt ccaaacttat cggcttcttg gtagttgcct
    30601 tgattgctgt tggtttggta ttcaacgctg gcggtgtgaa agatgtactg ttagagctgt
    30661 tcaataagat tatcggtgca taaaatttta ttgttgtgct gatatgagaa tggtataatt
    30721 tagaatatga aataaagtga atacgatttg aggttgaaaa tatgattatt tatagcaaat
    30781 tggaaatcaa tagaataaaa gatttttggg agttattaaa tcgtttagat actgaaacag
    30841 attacatgat gtacgaacca aatgaaagaa aagcgaaaac tactattcaa gaattaaaat
    30901 tagatattca agacaatgta attcaaggtt ttgatttttt gcaagtggca acagaaaatg
    30961 acaaaatagt tggttatatt agagcagaaa gaggaaaatt tgaaagaaat tttcatactg
    31021 catatattgt tataggtatc ttaaaaaaat atagaggaaa aggtattgga actacttttt
    31081 ttaataattt agatttatgg gctaaaacaa ataatattgt ccgtttggaa ctgacagttg
    31141 aatgttgtaa taatactgca aaaaatttgt atgaaaaaaa tggttttaaa attgaaggaa
    31201 taagaaaaaa atcaatgttt gttgctggtt cctttgttga tgagttttat atggcaaaaa
    31261 ttctataaaa taaattttca acttcattat ttacaaagta attggtctta ggattgaggt
    31321 gttttattat gaatgagaga gaaaaaatca ttcgcttatg gttcgatatg tggcttaaac
    31381 agcaagattt aggaatggat aaaattttta cagaagatgt tgtttatacg gaaagttggt
    31441 gtcctaaata taaaaatctt aaaacagtaa aacattggtt taatgaatgg aatactcgtg
    31501 gtaaagtcat tatttgggat attaaacagt tctttcataa agaaaatcaa actgtcgtag
    31561 aatggtattt taaaaatgaa atgaatacgg gaagtgttga agaatttgac ggtatttcct
    31621 taattgaatg gacagaagat aacaaaatca aatcattaaa agaatatggt tgcaatttga
    31681 ataactacaa tccatatcag cacagcgata gccctcaatt tagagatgaa aaaataagct
    31741 ggttttaaaa cttaatcaaa ttatatctat acacacaaag cagttagtct taggattgac
    31801 tgcttttttc ttaccaaaat ttcagatttg agtgatgaaa tgaacgatat ttttaaggat
    31861 atgcaggcaa aagtcggctg tgattatctt tccgacctgc cctcttacaa gcgtaaggtg
    31921 tggcatgaaa tgaaacgact gaaccctgcc gatcatgaag aaagacagtt agaagatttt
    31981 tctaaatatg tgtttggtat gtcgtaccag accttaaaag atgtgatgaa acaacagaaa
    32041 ggacgtgagg aacaatgcag gaaacaaggg tgctggtgga aacgaaagga acaactggcg
    32101 aagaaacaac atcatactgg ttcgacctgc cgatagatgt tgccgagttt gaagaaaagt
    32161 taggtgtcgg tgcagaaagt caagattatt gtattatcga aaaggtactg ccctttgctg
    32221 atgaaatcca cgaacataca agtgtgtatc agctcaacga attagatttt atgtaccgcc
    32281 agctttcaag cgatatgcag gaagaatata cagcacttct taccgtgtgt gaaaatttag
    32341 aagcacttta tatttgcagg aacgtgatta ccgtttatcc cgactgcaaa agcatgatag
    32401 atgttgcaag gcaaaagctg atgaacgacc cgacgttcaa acatttatcc gaggactgtc
    32461 aagaatacta ttttgacttt gaagcctacg cttctcactt gcaggaacac gggaaatttt
    32521 tagtaacaga acacggtatt tttgaactgc cagagtagga aatgaggtgg tgcttatgat
    32581 tgatgatatg gcggtttaca ttgctaatct tggcaaatac aatgagggct atttagttgg
    32641 tgcttggttc acgttcccca ttgacgagga agatgtgaaa gaaaaaatcg gattgaatga
    32701 acagtatgag gaatacgcaa tccatgatac cgataacttt cccattgcga ttggcgagta
    32761 tgtttccatt gaagaactta atgagatgta tgaaatgata gaggaacttc ccgactatat
    32821 cgtagagtgt ctggacgaat ttatcagcca ctacgggact ctggaagaag tcgtggaaca
    32881 caaggacgat atttattatt atcccgactg tgaaaccatg acagatgttg cctactacta
    32941 catagacgaa ttgcaggcac ttggcgacat tccacccagc ttacagaact acattgacta
    33001 tgaagcctac gggcgagatt tggatatggg cggttacttt attgaaacaa gccgaggtat
    33061 gtgcgagata ccatactaac gctggaagat cagcgacaag cattgttgct actgacagcg
    33121 tatttctctt ttaagggaca gtctgaaaca tggctgtcct tttctatttt gaaaggagct
    33181 gaaagaactt gaaaaagatt aaatcttata cgggtatctg gaacgtggaa aaagtcttgt
    33241 atgcaatcaa tgactttaac ttgccctttc ccgttacctt tacacagatt acatggtttg
    33301 tgattacgga atttatcatc attctgtttg gggatattcc cccactttcc atgattgagg
    33361 gagcatttct caaatactt
//
LOCUS       DAEQCW010000035        33251 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.035, whole genome shotgun sequence.
ACCESSION   DAEQCW010000035 DAEQCW010000000
VERSION     DAEQCW010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33251)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33251)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33251
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.035"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     regulatory      255..298
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00522"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF00522"
     gene            399..1367
                     /locus_tag="KRO40_001663"
     CDS             399..1367
                     /locus_tag="KRO40_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside hydrolase"
                     /protein_id="HBH2092484.1"
                     /translation="MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPAN
                     IGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQDTHGEDGIGENFYQKVVGAKAK
                     NGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
                     SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYI
                     TEITRFYIDFHWEQEGIIGCVINDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIV
                     DSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEGVI"
     gene            1369..1932
                     /locus_tag="KRO40_001664"
     CDS             1369..1932
                     /locus_tag="KRO40_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH2092485.1"
                     /translation="MKRKICVKTITLIAFGISINIIGAFIAMGLRLPVYLDSIGTIMI
                     ASLLGPKYAVVTGVFGSLISGITFDVYSLYFAPVQISTGLLAGIAFKKNFLRGLKTPL
                     GVLLFAIPTSIISSIISAFLFGGMTSSGSSYIVQILKVLGLGDVFSVFVTQVFTDYGD
                     KLLAVVLVNLGLNAVPKTLKVSLTGGK"
     gene            1940..2629
                     /locus_tag="KRO40_001665"
     CDS             1940..2629
                     /locus_tag="KRO40_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092486.1"
                     /translation="MDRYSEITNKNQREIVLLKGFPCIWGKCSFCDYIDDNSNLEEEM
                     NKLNLKVLKNVTGKYGVLEVINSGSCFELPKDTLEKIKCIIKEKNIKKLFLESHWSYK
                     NRLKEMREYFEIPVVFKIGVETFDNDFRNNILNKNANFKTPQDVKEYFDSPCIMVGIK
                     GQTKEMIDKDIEIILNTFEKATVNVFINNSSSIKRDEELVKWFVSKYKFLDENPNIEV
                     LYNNTDFGVGD"
     gene            2756..3484
                     /locus_tag="KRO40_001666"
     CDS             2756..3484
                     /locus_tag="KRO40_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH2092487.1"
                     /translation="MMFDRGKWNKLDYNELLEYMMSIQDIKYRDFNKKLIPGTENIIG
                     IRVPNLRKLSKEISQGNWKEFLEVAQDTYYEEVRLQGMVIGNINSNFEETLYYVKRFI
                     PKIDNWSVCDGFCSDLKSMKKYKENMYDILKKYVYSKNPWEIRFALVMFLIYYVDDKH
                     IKEIFEYCNNIQSEEYYVKMGMAWLLSICFIKCEEETFLYIKNNNLDDFTYNKMLQKI
                     IESNRVDLEKKNIIRSMKRKTRRC"
     gene            3498..4172
                     /locus_tag="KRO40_001667"
     CDS             3498..4172
                     /locus_tag="KRO40_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH2092488.1"
                     /translation="MNNNEDRIDKFLELQSKGFKFAEIAQNLKISQSTLRTFLNKKGY
                     KSEKGKYILKDELNYNKSLDNRNLEEEKAKEYEKSKKNTISNRKKVSTKKKISNEKAL
                     SKSVEQIEFNDTGLKNAKPKQNIKPKKDRKINITQEDLDKLCEVYDWYLEVKDYNIKP
                     KKVSNKKDVHIDDEHIDELKTTRIRIDKEIWNDFERLCSNSNFEKHQILTQALKEFMK
                     KYKNLL"
     gene            4198..5034
                     /locus_tag="KRO40_001668"
     CDS             4198..5034
                     /locus_tag="KRO40_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092489.1"
                     /translation="MNKIVKKSISLMIILTIFIFMLTACEKDEQPDSVDIQTEDKNEI
                     KIDEGNAKVLNIGKSEIINIDEGDKVDTSTKVENNSTFNISNVELIYNEYDENKKIIS
                     SDSKALLDMTLMPGKVAYIECGHKTFVKGVEVYAYEYEAEGKIVYVNLKENTINIRNN
                     NIKLENSSQYEVLSTSELKKVNESNEGITYQVKVKNSSSKDLGNIILKTAEVNENGEY
                     LTVNRVPSYKILKPSEETDIDILCSTKAKSVEIVGYTYDDIKEKANVDIDLKSHKVKI
                     DK"
     gene            5050..5721
                     /locus_tag="KRO40_001669"
     CDS             5050..5721
                     /locus_tag="KRO40_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092490.1"
                     /translation="MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLINQNIY
                     DLVILDLMLPNINGFDILKKMRINNIDTPVLILTAKETLDDKVEAFTIGANDYLTKPF
                     YMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
                     FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGY
                     IFDDK"
     gene            5711..6943
                     /locus_tag="KRO40_001670"
     CDS             5711..6943
                     /locus_tag="KRO40_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092491.1"
                     /translation="MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSG
                     IDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYVYEDGRISYYTQNEYFDELLPDR
                     RLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
                     IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTV
                     NDEVETIATAMKETRRLKKMITDLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIA
                     EFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGDEIALELKEDIEDEV
                     TLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVT
                     SDVDIGTTFELSIPKKLK"
     gene            7093..7410
                     /gene="trxA"
                     /locus_tag="KRO40_001671"
     CDS             7093..7410
                     /gene="trxA"
                     /locus_tag="KRO40_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBH2092492.1"
                     /translation="MAKVINTSEFRSSVEGSKGVVVVDFFATWCGPCNMLGPVFAELG
                     EEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFKDGKPVETLIGFMPKNKIEMQVK
                     SYL"
     gene            7427..8305
                     /locus_tag="KRO40_001672"
     CDS             7427..8305
                     /locus_tag="KRO40_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH2092493.1"
                     /translation="MRYDIAIIGSGPAGLSAAINAKIRNKTIIMFGNDNLSNKLVKAP
                     SIDNYLGFYDISGDELKDKFKSHIDSMDISIENKRINNIYAMGEYFTIMSGNDMYEAT
                     TVILATGVEYTRPIKGEEEFLGRGVGYCATCDAPLYRNKKVAVIGYNEESKEEANFLS
                     ELTSKTYFIPMYKKDNLMRSSDNLDDSIEVIHDRPVQIDGDKLVNKVSFKENHIEVDG
                     VFVIKDSTAPSALVPGIEIDGIHIKVDNNMKTSIDGCFAAGDCVGKPYSYIKAAGQGQ
                     IAALNAVYYLDKLKRA"
     gene            8575..8943
                     /locus_tag="KRO40_001673"
     CDS             8575..8943
                     /locus_tag="KRO40_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2092494.1"
                     /translation="MENLVKIFKALSDETRLNILILVSKRNICQKGISKYLGISDSAV
                     SQHIKILKDVGIITGYKEGYYVLYHINKESFNICVDFINSMLSNSSESFIDVFDVNTI
                     HLGCSKECKSIKKCCKRREK"
     gene            8946..9317
                     /locus_tag="KRO40_001674"
     CDS             8946..9317
                     /locus_tag="KRO40_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifB/NifX family molybdenum-iron cluster-binding
                     protein"
                     /protein_id="HBH2092495.1"
                     /translation="MKVCIPVEENKGLDSKPYGHFGSAPIFVVCDLESGEVKSLDNGD
                     LDHEHGKCQPLKALSGTAVDAVVVGGIGQGAIIKLNGMGIKVYRAEGDTISANLDLLK
                     NGKLVEFPSDHTCSHDGCGHH"
     gene            complement(9462..9917)
                     /locus_tag="KRO40_001675"
     CDS             complement(9462..9917)
                     /locus_tag="KRO40_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092496.1"
                     /translation="MNINTVQGDSIEVLLRQLGATRISKVSSTLYFIKFDLGDGWEIS
                     YTYNINAKDQYFLQRIEPYPIGRGLFNDEYEIVSFISKDLKKFLNAKNSSNFKTFVEV
                     TRKVNSIIDNVEELFLNYNVDGDDLKTLNKELNDILNDIDYIEKHTKKI"
     gene            complement(9956..11221)
                     /locus_tag="KRO40_001676"
     CDS             complement(9956..11221)
                     /locus_tag="KRO40_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ArsB/NhaD family transporter"
                     /protein_id="HBH2092497.1"
                     /translation="MEFQQIIAICIFLIVMAAIITEKVNRSIAAVGGALLMIIFNILT
                     LDEGLSHIDFNTIGVLVGMMLFVAVVKNSGLFEYIAIWTAKKAKGDPWKIMICFAIIT
                     AILSAVLDNVTTVLLIGPMTIVITQILGLNPVPFLITQILASNIGGTATLIGDPPNIM
                     IGSAANLSFMDFVINLGPAVIVILAITIICFRFIYGKELVVNERAKNAILKLDEKKSV
                     KDKPLLIKSLILIAFILFGFMFHSTIHIDSSVVALTGASIMLLIGKQDVDEIMAGIEW
                     STILFFMGLFVVVGGLVEVGIINKLAQALIGLTEGHLVFTMLLILWLSAIVSSFLDNI
                     PFVATLIPLILTMQAEGIDVMPLWWATSLGACLGGNGTLIGASANVVLAGIGNKHGHP
                     ISFKEYFKIGFPLMIISIIISTVYLIIKF"
     gene            11691..13142
                     /locus_tag="KRO40_001677"
     CDS             11691..13142
                     /locus_tag="KRO40_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBH2092498.1"
                     /translation="MDFFNGILTSINNAVVYVNNYLWSYILIIMLVVIGIYFTIKTNF
                     VQFRYFIEMFRLLGDGTANKNAKKEGKISSFQAFCISTSSRVGTGNIAGIAIAVVAGG
                     PGAVFWMWLIALIGSASSFVESTLAQIYKVKDGQAFRGGPAYYMEQGLNKKWMGILFS
                     ILITICYGFVFNAVQANTVSLAFNNAFGISKMAMGIGLGILTAIVIFGGVHRVAKVSE
                     IIVPVFAGLYILVALAIVVMNITEIPSVIALIVESAFDFKGMAIGTFMGVVMTGVKRG
                     LFSNEAGMGSAPNAAATAHVTHPVKQGLIQSLGVFTDTIIICSCTAFMVLLYSGYSSS
                     GATGIELAQEALTHHIGPVGNIFIAVCIFLFAFSSIVGNYYYGESNMEFMSGSKTKLN
                     VFRVFVVGMVLFGSLTQVDVVWNLADLFMALMAIINLIAIALLGKYAFIALKDYTSQK
                     KSGIKDPVFIADEIEGLEKVSEWHRELSEEHLG"
     gene            complement(13361..13822)
                     /locus_tag="KRO40_001678"
     CDS             complement(13361..13822)
                     /locus_tag="KRO40_001678"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HBH2092499.1"
                     /translation="MIYEGKLIGKDLKIGIINSRFNEFITSKLLSGAEDCLLRHDVSP
                     ENIEIVWVPGAFEIPLVAQKMAKSGKYDAIICLGCVIRGATSHYDYVCSEVSKGIAKV
                     SLDSELPVIFGIVTTENIEQAIERAGTKAGNKGYDCAMNALEMANLFKSLN"
     gene            complement(13927..15120)
                     /locus_tag="KRO40_001679"
     CDS             complement(13927..15120)
                     /locus_tag="KRO40_001679"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HBH2092500.1"
                     /translation="MFNTIEEAIEDIKNGKMVIVVDDESRENEGDLLMAAEMATPESI
                     NFMATYGRGLICLPATEKKFKSLNIPLMVRENTDTFQTAFTVTIDGADTLTGISAYER
                     AETVKLFCDENSTSKDFKTPGHIFPLIAKTGGVLVRDGHTEASVDLARLAGFKEIGLI
                     CEIMKDDGTMARVDDLMIFKEKHNLKIITIKDLIEYRKINETTIEKVSSAFLPTKYGN
                     FEIIGYRDTYSNEEHIALTYGNINIENTLVRLHSECLTGDVFHSLKCDCGLQLESSMK
                     KIVENGSGVLIYMKQEGRGIGLLNKIKAYKLQEEGYDTVEANLMLGFEEDMRDFYMAA
                     QILKNLNIKSINLLSNNPDKINQLEKYGIKIENRIPINEEINDFNKLYLKTKKDKMGH
                     LLDII"
     gene            complement(15143..15808)
                     /locus_tag="KRO40_001680"
     CDS             complement(15143..15808)
                     /locus_tag="KRO40_001680"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HBH2092501.1"
                     /translation="MFTGIVEEVGILRKITANGKSGKVTILSNKILDGTNLGDSIAVN
                     GVCLTVSNLGKNEFTADVMMETIRSTNLGLLNANDKVNLERAMSLSSRFGGHIVTGHV
                     DGKGTICKFEKDENAVLVSIRPDKKLLSSMILKGSVAIDGVSLTISYLDDEIFKVSII
                     PHTKINTILLTKNVGDFVNLESDVIGKYVNNFMANNYKELNSNSNNHKSNIDKDFLFK
                     NGF"
     gene            complement(15842..16954)
                     /gene="ribD"
                     /locus_tag="KRO40_001681"
     CDS             complement(15842..16954)
                     /gene="ribD"
                     /locus_tag="KRO40_001681"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HBH2092502.1"
                     /translation="MNFVNQKEKDIYYMKKAIELAKNGEGFVNPNPLVGCVIVKASNI
                     IGKGYHEKFGSNHAEVNAINSAKQSLKDSTLYVNLEPCSHYGKTPPCVDKIIQNKIKR
                     VVISTLDPNPLVCGNGVKKLKDNNIDVTVGILEDEARDLNEAFFYHIKNKRPLCIVKS
                     AVSLDGKIATKSLESKWISNESSRYLTHKYRNKYQSIMVGINTVLNDNPLLTCRLNQE
                     KVSHPTRIVIDTHLKLPLNSNLVKDKTSKTIVFTCCKESIKLSMLKENNVETIISPSK
                     NNLVDLEFVMYKLGELNIDSVLVEGGATLNDSLFRNKLVDKVKLFLSPKIIGGKDAPT
                     FVSGEGINHLSDSTQLTINNVTLIDGDILIESDVLN"
     regulatory      complement(17086..17207)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            17396..19879
                     /gene="recQ"
                     /locus_tag="KRO40_001682"
     CDS             17396..19879
                     /gene="recQ"
                     /locus_tag="KRO40_001682"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase RecQ"
                     /protein_id="HBH2092503.1"
                     /translation="MNKKLLEILSKYYGYTSFRKGQESIINSILSEKDVLAIMPTGGG
                     KSICYQIPALILDGMTIVISPLISLMKDQVDALKTMGISAAFINSSLSSKEFNEILNN
                     IRKNNYKILYIAPERLDAQEFIELINNNNVSQVAIDEAHCVSQWGHDFRLSYRRISDF
                     IKNLPKRPIVTAFTATASEEVRTDIINLLCLENPDYYITGFDRENLSINIVKSSSKNK
                     YILDYIQNHKNESGIIYVATRKEVENIYNGLSKRNISVSKYHAGLSKNERSKNQEDFI
                     NDNVDIMVATNAFGMGIDKPNIRWVIHYNMPQSIENYYQEIGRAGRDGEKSECVLLFS
                     PGDVHIQKYLIDIGVENPERKLFQHKKLQYMIDLVYSNSCYRKTILSYFGENYIDNCN
                     NCSNCLVEGEIVDKTIDAQKVISCVARMKRSYGVTTIVDVLRGSKNKKILQLGLNTLS
                     TYNIMRDYSSEDLKNFVNTLVSHGFLDLVETLGNGNRGSFPTIRLNEMSMKVLKGEVK
                     VEFKEIVMTKSLEVEDELYNALRELRHSIASEERIAPYMVFGDGTLRAMSSSYPINKE
                     EMLDISGVGEIKYQKYGRDFEAVIKEYVEKNNINKKIDEKNVDSKNVNSDFLEVNTDK
                     VLYEKLLVIREEYATKEKLPAYMILANKALKEISGRYPLDEEQLKDISGIGGVKFEKY
                     GASILAEVNKYVKENNINVIWEKKGKRKLILDGESRKNNEIALDLLNQGKDIQSISQE
                     IEVSLSTIIGYVHDYVKDGHSISFELGLENFYNEDKKKMILEVCEKVGYDNLNNIKRK
                     LPDSIKYENIRAVILDSYLENLKNNIIAE"
     regulatory      19968..20079
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            20221..21522
                     /gene="thiC"
                     /locus_tag="KRO40_001683"
     CDS             20221..21522
                     /gene="thiC"
                     /locus_tag="KRO40_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomethylpyrimidine synthase ThiC"
                     /protein_id="HBH2092504.1"
                     /translation="MNYTTQMDAARKGIITKEMEIVSQKEQVDVNELRELIANGQVVI
                     PANKNHKSLSAEGVGKNLRTKINVNLGISRDCKDIEKELEKVRVAIDMKAEAIMDLSN
                     YGKTREFREKVVEMSPAMIGSVPMYDAVGYLEKELKDITEEEFLNVIRQHAIDGVDFI
                     TIHAGLTRSVCQKIKNHERLTHIVSRGGSLLFAWMELNNKENPIYTNFDKILDICEEY
                     DVTLSLGDACRPGCIKDSTDGVQIQELVVLGELTKRAWERNVQVMIEGPGHMAIDEIE
                     ANVVLEKRLCHGAPFYVLGPLVTDIAPGYDHITSAIGGALACAKGVDFLCYVTPAEHL
                     RLPNLDDMKEGIIAAKIAAHAGDIAKNVKGAREWDNKMSKARADLDWCEMFRLAIDPE
                     KAKRYRDESTPTHEDSCTMCGKMCSMRTVKKILNNEELNLI"
     gene            21576..21770
                     /gene="thiS"
                     /locus_tag="KRO40_001684"
     CDS             21576..21770
                     /gene="thiS"
                     /locus_tag="KRO40_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfur carrier protein ThiS"
                     /protein_id="HBH2092505.1"
                     /translation="MKVNGKEIEFEKDLTVIDLLNKYNLKSDRVVVEVNLEIIEESNY
                     NTYVLKDEDIVELISFIGGG"
     gene            21763..22566
                     /gene="thiF"
                     /locus_tag="KRO40_001685"
     CDS             21763..22566
                     /gene="thiF"
                     /locus_tag="KRO40_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine biosynthesis protein ThiF"
                     /protein_id="HBH2092506.1"
                     /translation="MVKIKIFVNELLTDVEENTTAYKVRDSYNNKCDVLVLNGYPIKT
                     DMTLCENDKLTLIQKGVKPSLDELESLLIARHTPNIHNKLKKGKVAILGLGGLGSNIA
                     ISLARIGVGELLLIDYDVVEPSNLNRQQYFIDDIGKLKTDAMIENIKKINPFIKLNKR
                     DIFLNKNNMDTIKDSDLIIEAFDDASCKAQVCNYVLINLKDKYLIASSGMAGYYDSNI
                     ITTKKIKDRFYICGDFVNEAKFGEGLMAPRVAICANHMANLATQILIDM"
     gene            22629..23399
                     /locus_tag="KRO40_001686"
     CDS             22629..23399
                     /locus_tag="KRO40_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiazole synthase"
                     /protein_id="HBH2092507.1"
                     /translation="MDKLVLGGHEFNSRLLVGTGKYGSNNILPEVIKESGSEIITMAL
                     RRVDLDNKQENILTYIPKEMTILPNTSGATNAEEAVRIARISRKMGCGDFIKIEVISD
                     TRYLLPDNEETIKATKILADEGFIVLPYMTPDLYAGRRLIEANAAAVMPLGAPIGSNR
                     GLQMKEMIRIMIDELDIPIIVDAGIGKPSQAMEAMEMGADAVLVNTAIASAGDPVQMA
                     RAFKLAVEGGREAYIAKTGNVSEFANASSPLTGFLGNL"
     gene            23416..24519
                     /gene="thiH"
                     /locus_tag="KRO40_001687"
     CDS             23416..24519
                     /gene="thiH"
                     /locus_tag="KRO40_001687"
                     /EC_number="4.1.99.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-iminoacetate synthase ThiH"
                     /protein_id="HBH2092508.1"
                     /translation="MSFYDVIEKYRDFDFDGYLNNVTDNDVLRSLSKDKLEDFDILNL
                     LSKTAVKHLEDMAQKAHKLSVQYFGKTVCLYTPMYIANYCVNQCVYCSYNIKSGIKRK
                     KLTMDEIREEGEVISKEGFKHLLVLTGESSFHSSVEYIGEAIEILREKFPSIGIEVYP
                     MEVEEYKYIVDKGVEGLTVYQETYDEEIYKRVHIKGPKSNYKFRLDAPERGAKAGMRT
                     LSIGALLGLNDFRKETFFTILHGKYLKTKYPHIELSYSTPRMRPFKGCFEELVDISDT
                     DLVQAMVCMRLFDPHAAINISTRENLEMRSHIIPLGVTKLSAGVSTDVGGHSQDEHDT
                     AQFKINDESTVKDVEKMLNSIGYQHVFKDWERF"
     gene            24520..25209
                     /locus_tag="KRO40_001688"
     CDS             24520..25209
                     /locus_tag="KRO40_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBH2092509.1"
                     /translation="MYLITNRKLCSEERYLEVIKESILSGVENIIIREKDLEYQELRK
                     LYMKIKTKINCIDFQEQISDESLKTNINQKEFRNKFKVNFIINSNIEFFEKVDCQGIH
                     LPFKLFLNLIENKYNFNENKILGLSLHKVEEVDYLEKLIRNQNIKIDYITLSHIYETK
                     CKEGLNPKGIELLKEAKKITDIKIIALGGILPSNVKETLKYCDDFAIMSTIMRSKDIK
                     KTISNYNEKLN"
     gene            25397..26791
                     /gene="yfcC"
                     /locus_tag="KRO40_001689"
     CDS             25397..26791
                     /gene="yfcC"
                     /locus_tag="KRO40_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative basic amino acid antiporter YfcC"
                     /protein_id="HBH2092510.1"
                     /translation="MTDSKKKRFIIPHTFTIIFLLIVLMAILTWIVPSGEFSREDVEG
                     RMVVVPGTYQSVESNPQGFADVFKAPIEGFIDSAEVVGFVLIVGGAFGIVNRTGAIEA
                     GIASVISKFKGKELLIIPISMILFGLGGTTFGMAEETLPFYMIFVPLMTSLGYDSLTA
                     IAIVFIGAAAGAAASTINPFSVGIAQALAQLAPGSGVTYRVVIFIAYILISIAFVMYY
                     AKKVKENPESSIVYEIDKNNKSILNQTSTEIKEFTFKEVSVLAIFGIGMAIMIWGVLS
                     QGWYIPEISMCFAAIGVLSGLVGRLSQIEISESFIDGAKDLASAALAIALARGIVIIA
                     QNGFIIDTILNSAAAFLGGLPKVIFVYLSFFLEAALAFLIPSSSGLASLTVPVLAPLG
                     DLVNISAQVIVTAYQFGVGLTNFITPTSGVLMGALAVAHIPFSKWVRFIMPILLILTA
                     VSLVFLTIGIYIGF"
     gene            27308..28675
                     /locus_tag="KRO40_001690"
     CDS             27308..28675
                     /locus_tag="KRO40_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase"
                     /protein_id="HBH2092511.1"
                     /translation="MGLKEFDFIEESIDMLRTMSPTLETISDEIEEYFENILDEKNQE
                     YINVTSRIKSESSLREKIIRNRYLKKYGEASNLIHNVSDLIGLRIECRFIEDENKIYR
                     LLRRYFNKTDDKINYYNKENKNIKLKLSERQPNKQKNGFEIYKIDGVFAYLDREVKFE
                     LQIKSLVNVFWSEIEHKIIYKNNTYLLADKFIKDMMDSIKNNLTMIDNQLLSIYKNFH
                     SGKSFNMKVSKKEIEKLFAKLVYDAFSEKMNKSIGFVVDFKKPCETILNYSFNKQDIS
                     DEVLGNFMLDEFARLNEIVNKDIDFNEQIEFEREPTFDDKFCKDLGNHFRSRLNTEFP
                     WNLFFRILFEIEPYNNTKDFENFVEFIKENVLLEENREQLLCQFEEDSKLIIEDIYDC
                     IFNSISEIDSVEILYNYNLEKINFTSSEIINCICREYECYGEYLEEKEKLMNTFKEKI
                     IQIFE"
     gene            28700..29308
                     /locus_tag="KRO40_001691"
     CDS             28700..29308
                     /locus_tag="KRO40_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor guanylyltransferase"
                     /protein_id="HBH2092512.1"
                     /translation="MRHFSNIYELSKIILEEAICIEKTGVILAGGKNSRMGRDKAFLE
                     LHDKLFIEIAIEAFKNFDELIIISNNEELYSKYDIKVYNDIVKDVGPIGGIYTALEYA
                     KYDIVTIACDMPYLNNQIVERIANKMDDKSVISVTNGKLQPLCSGYKKSIINKVSLCI
                     RENDLKLRSFIDKIDKSYIYFDEEDLFLNVNTVDEYKKLTKV"
     gene            29356..29727
                     /locus_tag="KRO40_001692"
     CDS             29356..29727
                     /locus_tag="KRO40_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HBH2092513.1"
                     /translation="MNLLKCDSWAVILNNSDKESKAYKILDELKRNMYKVVAIDEEKK
                     PIEGIDVYECLKDVPHNIDVVAIIDKQSKMDVILEEVELLDIQNMWFEKGSFSEMMIK
                     KTKDLKLNIEYNLSLYDELTR"
     gene            29906..30244
                     /locus_tag="KRO40_001693"
     CDS             29906..30244
                     /locus_tag="KRO40_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal-binding domain-containing protein"
                     /protein_id="HBH2092514.1"
                     /translation="MLIVTTEKVEGKKISKVLGLVRGSTIRAKHVGKDIGASFKNLVG
                     GELTGYNEMLTEARQIAIGRMVEDAEAKGANAVIAFRLSSASVMQGAAEMLAYGTAVV
                     LEDDNSILEK"
     gene            30710..31213
                     /locus_tag="KRO40_001694"
     CDS             30710..31213
                     /locus_tag="KRO40_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MogA/MoaB family molybdenum cofactor
                     biosynthesis protein"
                     /protein_id="HBH2092515.1"
                     /translation="MFNVAIITLSDKGYEGKREDITGKKLTEFVENTGVYKVTEYVLI
                     KDDKEMLKENIIRLCNSNKIDLILTNGGTGFSKRDITPEATKEVLEKEIPGLSEYMRM
                     KSTEITKKAILSRGVSGIRNNSIIINLPGSPKGAVENLSFIIDVLDHGIEVLRGEATE
                     CATKKSE"
     gene            31260..32219
                     /gene="moaA"
                     /locus_tag="KRO40_001695"
     CDS             31260..32219
                     /gene="moaA"
                     /locus_tag="KRO40_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP 3',8-cyclase MoaA"
                     /protein_id="HBH2092516.1"
                     /translation="MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLS
                     FEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELIKFTKEECGINNIGMTTNAIGLS
                     DRIFELEKCGLNKVNISLDSLKEYKYKSITRGGNLKDVLKSIESCLNLGIKVKLNCVA
                     ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKV
                     KNDEKSTAEYYMFKGAKGRIGIITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIK
                     PFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG"
     gene            32223..32693
                     /gene="moaC"
                     /locus_tag="KRO40_001696"
     CDS             32223..32693
                     /gene="moaC"
                     /locus_tag="KRO40_001696"
                     /EC_number="4.6.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic pyranopterin monophosphate synthase MoaC"
                     /protein_id="HBH2092517.1"
                     /translation="MLTHINEKGYAKMVDISEKDDTKRTAVATATITLSKEALEKVKN
                     GQIKKGDVLSVAQVAGIMGAKNTSSNIPMCHQIKLVGCDLEFDVDDSMSAIKIYATCK
                     SLGKTGVEMEALNACSLAALTIYDMCKAVDKKMVISNIHLVEKTGGKSGDFKFE"
     gene            32729..33160
                     /locus_tag="KRO40_001697"
     CDS             32729..33160
                     /locus_tag="KRO40_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MOSC domain-containing protein"
                     /protein_id="HBH2092518.1"
                     /translation="MAKVVSINISEKKGVIKVPVQCAELKINHGIVGDAHAGNWHRQI
                     SLLGKESIDKMKMKGFDQLKYGDFAENVTTEGIEVFSLPVGTKLRIGQCEVEVTQIGK
                     KCHNGCEIKKLTGDCVMPREGIFVKVLKEGIINVNDSIDVI"
BASE COUNT        13029 a         3544 c         5648 g        11030 t
ORIGIN      
        1 gataataaat taatgttatt aattgtaata tttaagatat tattgtataa taataatcgg
       61 tttaaatgcg ccacatctta ttaaagttgg ttcataattc taaataaact ttaataagat
      121 acattaaaat ataataaatt cttttatgct ataaaattta ttttatagct attaaatcag
      181 atgtttaaaa attttttaac ggtctatagt ttttaagagt cttatagtaa gtagcctaaa
      241 aatatgattt tacatctgta cttgttcgag aactccaagt ataaaaaact aaggaattat
      301 atagtggcag tatataatta atacccttag acacaccttt ttgaaagtgg aaaaaagatg
      361 tgtagttctc ctcgaccaca aatcaaggag gataaaaaat ggaaaagaga aaagtaataa
      421 ttgattgtga cccaggaatt gatgattctt tggcaattct tctggcttta aactcaccag
      481 agctagaagt aattggaatt accacatgtt gtggaaatgt cccagcaaat ataggtgcag
      541 aaaatgcact aaaaacactt caaatgtgtt cttcactaaa tattccagta tatataggag
      601 aagaagcacc actaaaaaga aaacttgtaa cagctcaaga tacacatgga gaagatggta
      661 ttggagaaaa cttttatcaa aaggttgtag gagctaaagc aaaaaatgga gcagtggatt
      721 ttataataaa tactttatat aatcatgaaa aagtatcaat aatagcactt gcaccactta
      781 caaatatagc taaagcactt attaaagata agaaagcatt tgaaaatctc gatgagtttg
      841 tatctatggg aggagcattt aggattcatg gaaattgctc tccagtagca gagtttaatt
      901 attgggtaga cccacatgga gcagattatg tttacaagaa tttatctaaa aaaatccaca
      961 tggtaggttt agatgtaact agaaaaattg tacttactcc taatattatt gagtttataa
     1021 atagacttga taagaagatg gcaaagtata taactgaaat aactagattt tatattgatt
     1081 tccattggga acaggaggga ataattggct gtgtgataaa tgaccctcta gcagtagcat
     1141 actttataga tagaagtata tgtaaaggat ttgaatcata tgtagaagtt gtagaagatg
     1201 gaatagctat gggtcagtct atagtggatt ctttcaattt ctataaaaaa aatcctaatg
     1261 caattgttct aaatgaagtt gatgagaaga aatttatgta catgttttta aagaggcttt
     1321 ttaaaggtta tgaagacatt atagactctg tggaaggagt gatatagtgt gaaaagaaaa
     1381 atatgtgtaa aaactattac acttatagct tttggtattt ctataaatat aataggcgct
     1441 tttatagcta tgggattaag attacctgta tacttagatt caataggaac tataatgata
     1501 gcttcacttt taggacctaa atacgctgtt gttacaggtg tgtttggaag tttaataagt
     1561 ggaattacgt ttgatgtgta ttctctctat tttgcaccag ttcaaatatc aaccggatta
     1621 cttgctggaa tagcatttaa aaagaatttt ttaaggggtt taaaaactcc actaggagta
     1681 cttttatttg ccattccaac atctataata agttcaataa tttcagcatt tttatttgga
     1741 ggtatgacct cttcaggttc atcatatata gtgcaaatct tgaaagtgtt aggactgggg
     1801 gatgttttta gtgtgtttgt aacccaagta tttactgatt atggagataa gctgttagca
     1861 gttgttttag tgaatttagg attaaatgca gttccaaaaa ctttaaaggt atcattgact
     1921 ggaggaaaat agatagaaaa tggatagata tagtgagata acaaataaaa atcaaagaga
     1981 aattgttctg cttaaaggat ttccttgtat atggggaaag tgttcttttt gtgattatat
     2041 agatgataat tctaatttag aagaagagat gaataaatta aatctaaagg ttttaaaaaa
     2101 cgtaactggg aaatatggag ttcttgaagt cataaattct ggaagctgtt ttgaattacc
     2161 taaggatact ttagaaaaaa taaagtgtat tataaaagag aagaatataa aaaaattatt
     2221 tttagaaagt cattggtctt acaaaaatag gcttaaggaa atgagagagt attttgaaat
     2281 tcctgtggta tttaaaattg gagttgaaac ctttgacaat gattttagaa ataatatttt
     2341 aaataaaaat gcaaatttta agactccaca agatgtaaaa gaatattttg attcaccttg
     2401 tattatggtt ggaataaaag gacaaacaaa agagatgata gataaagata tagagattat
     2461 cctaaatact tttgaaaaag cgacagtgaa tgtttttata aataattctt ctagtataaa
     2521 aagagatgaa gagttagtga aatggtttgt tagtaagtat aaattcttgg atgaaaatcc
     2581 aaatatagaa gttttataca ataatacaga ctttggtgta ggagattagc attaatttag
     2641 tttaaattta aaattgaaaa gtttcttatg tttttgaaaa agcttctaat agttagaagc
     2701 tttttttgta gagttttatg ttacaataag aaaaaaggaa ttaaggagca attaaatgat
     2761 gtttgatagg ggaaaatgga ataaattgga ttataatgaa cttttagaat atatgatgtc
     2821 tatacaagat ataaaatata gagattttaa taaaaagctt atacctggaa cagaaaatat
     2881 aataggtatt agagttccta atttaagaaa gttatcaaaa gaaataagcc aagggaattg
     2941 gaaggaattt ttagaagtag cacaggatac atactatgaa gaagttaggc tacaaggtat
     3001 ggtaattggc aatataaata gtaattttga agaaacttta tactatgtaa aaagatttat
     3061 acctaaaatc gataattggt cagtttgcga tggattttgt tctgatttaa agtctatgaa
     3121 aaaatataaa gaaaatatgt atgatatact taaaaaatat gtttattcaa agaatccatg
     3181 ggaaattaga tttgcattag ttatgttttt aatatattat gttgatgata aacatattaa
     3241 agaaatattt gaatactgta ataatataca aagtgaagaa tattatgtta aaatgggtat
     3301 ggcatggttg ctatcaattt gttttattaa atgtgaagag gaaacttttc tctatataaa
     3361 aaataataat ttagatgatt tcacttataa taaaatgcta caaaaaataa ttgaatcaaa
     3421 tagagtagat ttagaaaaga agaatataat aagaagtatg aaaagaaaga caagaagatg
     3481 ttgacggagg aatattaatg aataacaatg aagacagaat tgacaaattt ttagaacttc
     3541 aaagcaaagg atttaaattt gcagagatag ctcaaaatct aaagattagt caaagtactt
     3601 taagaacttt tttaaataaa aaaggatata agtcagaaaa aggtaaatac atattaaaag
     3661 acgaattaaa ttataataaa agtttggata atagaaactt ggaagaagag aaagctaagg
     3721 agtatgaaaa aagtaaaaag aatactataa gtaatagaaa aaaagtaagc accaaaaaaa
     3781 agatttctaa tgaaaaggct ttaagtaaaa gtgttgaaca aattgagttt aatgatacag
     3841 gtttaaaaaa tgcaaagcca aaacaaaata ttaagcctaa gaaagataga aaaataaata
     3901 taactcaaga agatttagat aagctttgtg aagtatatga ttggtattta gaagtaaaag
     3961 attacaatat aaagcctaaa aaagtatcta ataaaaaaga tgtacatata gatgatgaac
     4021 acatagatga attaaaaaca acaagaatac gtatagataa agaaatatgg aatgattttg
     4081 aaagattatg tagtaattcg aattttgaaa aacatcaaat acttacacag gcattgaaag
     4141 aatttatgaa aaagtataaa aatctactat aaaatactac tatatgaggt gcttaatatg
     4201 aataaaatag taaaaaaatc aatttctcta atgattatat taacaatatt tatttttatg
     4261 ttgacagcat gtgaaaaaga tgaacagcct gattcagttg atattcaaac agaagataaa
     4321 aatgagataa aaatagatga gggaaatgca aaagtattga atataggaaa atcagaaatt
     4381 ataaatatag atgaaggtga taaagtagat acatcaacaa aggtagaaaa taattcaaca
     4441 tttaatatat ccaatgttga attgatatat aatgaatatg atgagaataa aaaaattata
     4501 tcttcggata gtaaggcttt gttggacatg actttaatgc ctgggaaagt tgcttacata
     4561 gaatgtgggc ataaaacttt tgtaaagggt gtagaagttt atgcatatga atatgaggca
     4621 gagggtaaga ttgtgtatgt taatttaaaa gaaaatacta ttaatataag aaataataat
     4681 attaagctag aaaatagtag tcagtatgag gtgctatcta catcagaact taaaaaagta
     4741 aatgaatcaa atgagggaat tacgtatcaa gtaaaagtaa aaaattcatc atcaaaagat
     4801 ttaggaaata ttattcttaa gacagcagaa gttaatgaaa atggagaata tttaacagta
     4861 aatcgtgtac catcatataa gattttaaag ccttcagaag agacagatat agatatattg
     4921 tgttcaacaa aggcaaaaag tgttgaaata gtgggatata cgtatgatga tataaaagaa
     4981 aaagccaatg tggatattga cttaaaatct cataaagtta agatagacaa ataaaggtag
     5041 gggatactta tgaaggtttt aatagttgaa gataataaga tacttttaga aagtgtagta
     5101 gaagaactta gcaagcattt tgaaactgaa aagtgtgaag atggagaaga agctttatac
     5161 ttaataaatc aaaatatata tgatttagtc attttagact taatgcttcc taatataaat
     5221 ggatttgata tcctaaagaa aatgagaatt aataatatag atacacctgt acttatattg
     5281 acagcaaaag aaacattaga tgacaaagta gaagcattta ctataggagc taatgattat
     5341 ttgacaaaac ctttttatat ggaagagtta gtagctaggg tatacgctat attaaggact
     5401 aatggaaaga taaaagaaag aaacggatta gaatttaaat ctttatattt agatacacta
     5461 gaaaaaagag tgtatattga aaaagaagaa ataaaacttc aaaacaaaca gtttaacttg
     5521 cttgagtatt ttgtattaaa taaaggttca attttattaa aagagcagat ttatgataga
     5581 atatggggaa ttgattcaga tgcaactatt gaaatagtgg aagtatatgt aagtaatcta
     5641 agaaaaaagc taagtaaata tggatatgat aaatatatta aaactaaacg taaggtagga
     5701 tatatattcg atgataaata agaatgtatt taccagtact aaaaatcatt taataaaaat
     5761 gtatattatt gtagtaggta gttttttaat aatcttttct atatttatat actcatattt
     5821 taggggactt acatatagtg gaattgatag tgagataaat gatgaacttg aatatatagt
     5881 ctctcaattt aaaagaactt catttttgaa cccaataaga ctcaaagatc ctaaagatat
     5941 ggtgtatgta tatgaagatg gaaggataag ttactatact caaaatgaat attttgatga
     6001 gttacttcca gatagaagac tagataaaaa aaattcgttt tttaaataca cagaaaatgg
     6061 atatactttt agagaattaa atgtagatgt aggtagatac caaatacaga taattagaaa
     6121 tatagattct gagatgaatt ctttaagaca gcttacatct gttcttataa ttggaatatt
     6181 aatttctgta ataattactt actttgtggc tgtatatctc actagaaaag ctttaattcc
     6241 aatagaaaca gcatggaaaa atcaagctaa gtttatacaa gatgcttctc atgaattaag
     6301 aacaccaata acaatagttt catcaaaatt agaaagtatg ttaaaatccc cagaaagtac
     6361 agtaaatgat gaagttgaaa caatagctac tgcaatgaag gaaactagaa gacttaaaaa
     6421 aatgataact gatttattgt ctcttactaa agaggactct attgttaaag ttaatttaga
     6481 agaaatagat ttagaaaagt tattggaaga aatatcagaa gactatattg acattgctga
     6541 gtttcaggaa aaaagattcg tgtttaattc taaactgaag aataaagtta taataacaga
     6601 taaaaataaa ttaagacaac ttatattaat tttcattgat aatgccttta agtatacaaa
     6661 attgggtgat gagatagcat tagaattgaa agaagatata gaggatgagg taactttact
     6721 tataagtgat actggtatag gcataaaaaa agaagagata cctcttatat ttgatagatt
     6781 ttttagaagt gaaaatgtaa gaaataaaga tttagaaggt tctggaatag gactttcaat
     6841 agctcgcatg attagtttaa acttatctat tgatataaat gtaacttctg atgtagatat
     6901 tggaactaca tttgaattgt caataccaaa aaagttaaaa taataaaaat ataaaaaatt
     6961 gtttttagaa atgaagaatg ggtatactaa ttagtataaa atataaaaag accttataaa
     7021 agtaaattta tatttataaa tttcatagta taattatata gggataataa agtttaatag
     7081 gaggatttaa aaatggcaaa agttataaat acatctgaat ttagaagtag tgttgaaggt
     7141 agtaagggag tagttgtagt tgatttcttt gcaacttggt gtggaccttg taacatgttg
     7201 ggacctgtat ttgcagaatt aggtgaagag atgaaggata aagctagatt tgtaaaagtt
     7261 gatatagatg agagtttaga aatagctcaa caattcaatg tatctacagt accaactatg
     7321 attatattta aagatggaaa accagtagaa actttaattg gattcatgcc aaagaacaaa
     7381 attgaaatgc aagtaaaatc atatttataa aaaatgggtg agtattatga gatatgatat
     7441 agctataatc ggcagtggtc cagctggatt gtctgctgct ataaatgcaa aaataagaaa
     7501 taaaacaatt atcatgtttg gtaatgataa tttaagtaat aagcttgtta aagctccttc
     7561 aatagataat tatttaggtt tttatgatat aagtggtgat gaattaaaag acaagtttaa
     7621 atcacatata gatagtatgg atatttcaat tgaaaataaa agaataaata atatttatgc
     7681 tatgggagaa tactttacaa taatgtctgg aaatgatatg tatgaagcta ctactgtaat
     7741 ccttgcaact ggggtagagt atactagacc aatcaagggt gaagaagaat ttctaggaag
     7801 aggtgtgggc tactgtgcta catgtgatgc accactttat agaaataaaa aggtagcagt
     7861 tataggatat aatgaagaat ctaaagaaga agcaaatttt ttaagtgaac tcacttcaaa
     7921 gacttatttt atacctatgt acaaaaaaga taatcttatg agaagttcag ataacctaga
     7981 tgattctatt gaagttatac atgacagacc agtacagata gatggagata aacttgtaaa
     8041 caaagtatct tttaaagaaa accacattga agttgatgga gtattcgtta taaaagatag
     8101 tacggctcca agtgcattgg ttcctggaat agagattgat ggcattcata ttaaagttga
     8161 caataatatg aagactagta tagatggatg ctttgctgct ggagattgtg ttggaaaacc
     8221 ctattcttat ataaaagcag ctggtcaagg gcaaatagca gctttaaatg ctgtttacta
     8281 tttagataaa ttaaagaggg cttaatattt atattgatta actttttaaa gatatttata
     8341 aaaaactgtc ttgaaataat tttattattt caagacagtt ttttattttt aagttattaa
     8401 taaaagtatt ttaaaatcta tatgtaatta cttttattaa taaaactcaa agttatatta
     8461 gtaaaaattg gaattattta taatatactc caaaatttaa aaataatggt tgaaaaatct
     8521 aattaagagt actataattt aattaagtaa ttacttaatc aaaatgaggt acttatggaa
     8581 aacttggtta aaatatttaa agcattgagt gatgaaacta gacttaacat acttatatta
     8641 gtatccaaga gaaatatatg tcaaaagggg atttctaaat atctagggat ttcagattct
     8701 gctgtttcac aacatataaa aatattaaaa gatgttggga taataacagg atataaagaa
     8761 ggatactatg ttttatatca tattaataaa gaatcattta atatatgtgt agattttata
     8821 aattctatgt taagtaattc tagtgaaagc tttatagatg tatttgatgt aaatacaata
     8881 catctaggat gcagtaaaga atgtaaatct ataaaaaaat gttgtaagag aagggagaaa
     8941 taataatgaa agtatgtata ccagtagagg agaataaagg attggatagt aaaccatatg
     9001 gacattttgg ttctgctcca atttttgttg tgtgtgattt agaaagtgga gaagttaaat
     9061 ctttagataa tggagattta gatcatgaac atggaaaatg tcaaccatta aaagcattgt
     9121 cagggacagc tgtagatgca gtagttgttg gaggaatagg acaaggagct ataattaaat
     9181 taaatggaat gggaataaaa gtttacagag cagaaggtga tactataagt gctaatttag
     9241 acttacttaa aaatggaaaa ttagtagaat ttccatcaga ccatacttgc tcacatgacg
     9301 gatgtggaca tcattaaaaa aaaacagctg atgaaatata tacttcatca gctatttttt
     9361 cttttaataa atacgatttt attcttttaa aaccaaaatt tagattttta tgttttttgt
     9421 agtatcctta ataatatttc aagtttacaa gtttactact tttagatttt ttttgtatgt
     9481 ttttctatat agtcaatatc atttaatatg tcattgagtt ctttattaag tgtttttaaa
     9541 tcatcaccat ctacattgta gtttaaaaat agttcctcta cattatcaat gatagaattg
     9601 acttttctag taacttcaac aaatgtctta aagttactac tatttttagc atttagaaat
     9661 ttttttaaat cctttgatat aaatgatact atttcatatt catcattaaa tagacctcta
     9721 ccaataggat atggttcaat tctctgtaaa aaatattggt ctttagcatt aatattataa
     9781 gtataagata tttcccaacc gtctcctaaa tcaaacttga taaaatataa tgtactactt
     9841 acttttgata ttcttgtggc accaagctgt cttaaaagaa cttcaatcga atcaccttga
     9901 acagtattaa tattcatata tacacatccc ctttagtatt attatactat attttttaaa
     9961 attttataat taaataaaca gtagatataa taatagatat aatcataagt ggaaaaccta
    10021 ttttgaaata ctccttaaaa gagataggat gaccgtgttt attacctata cctgctagta
    10081 caacattagc agatgctcct attagtgttc catttcctcc aagacaagct ccaagagatg
    10141 ttgcccacca tagtggcatt acatcaatac cttcagcttg catagtcaaa ataagaggaa
    10201 ttagtgttgc aacaaatgga atattatcta agaaagaaga gactatagct gacaaccata
    10261 atatcaacaa cattgtaaat acaagatgtc cttctgtaag tccaatcaat gcttgagcca
    10321 atttgtttat tatcccaact tctactaatc caccaactac tacaaataat cccataaaga
    10381 ataaaattgt agaccattca atacctgcca taatttcatc tacatcttgt tttcctatta
    10441 aaagcattat agatgctcct gtcagtgcta caacagaaga atctatgtgg attgtactgt
    10501 gaaacataaa accaaaaagt atgaatgcta ttaatataag gctttttata agtagaggtt
    10561 tatctttaac agattttttt tcatctagtt ttaatattgc atttttagct ctttcattca
    10621 caacaagttc ttttccataa ataaatctaa agcatattat agttatagca agtattacta
    10681 taacagcagg acctaaattt attacaaaat ccataaaact aagattggca gcactaccaa
    10741 tcataatatt tggagggtct cctataagag tagctgttcc tcctatattt gaagctaaaa
    10801 tctgtgttat taaaaatgga actggattaa gtcctaatat ttgtgtaata actatagtca
    10861 ttggtccaat aagtaagacg gttgtaacat tatctaatac agctgataaa atagctgtta
    10921 taatagcaaa acaaatcatt atcttccatg ggtcaccttt ggctttcttt gcagtccaga
    10981 tagctatata ttcaaataac cccgagtttt tgacaacagc tacaaatagc atcataccaa
    11041 ctaatacacc aatagtattg aaatctatat ggcttaatcc ttcatcaagt gtaagtatat
    11101 tgaatattat cattaatagt gcaccaccaa cagctgctat ggatctgttt accttttctg
    11161 taataatagc tgccataact attaaaaata tacatatagc tattatttgt tgaaattcca
    11221 taatataagt acctccattt gtattatttt gtgcctaatg ctagtactat atatagtatt
    11281 acttttttat tgttttttca atggatgtat gaaagtatat tatttaacaa agtttttgga
    11341 aaattgacag aatttaaaga aaatttttgt tatttaaata aattttaaaa ttattccatt
    11401 gataataata ttaaacgaca aacgaaaaaa tatacccttt aaactagaat ttattgtatc
    11461 taataacaat tataaaatat taaatatatc tatattataa aaacaataaa aaaaggtttg
    11521 atttgaatat aaaactgcaa tatattaaaa aaattattca ttttaaacct tgtaatttga
    11581 ttttataaat attataatta aattaatgaa tttttaacaa ggaattattc atttttttga
    11641 ttttaagatt tattgagaaa acaaaactaa ataggggggt aattaatata atggattttt
    11701 tcaatggtat tttaacgagt attaacaatg cagtagtata tgtaaacaat tacttatggt
    11761 cgtatatctt aattataatg ttagttgtaa ttggtattta ctttactatt aaaacaaatt
    11821 ttgtacaatt cagatatttt atagaaatgt ttagacttct gggtgatggt acagcgaata
    11881 aaaatgcaaa aaaggaagga aaaatctctt catttcaagc attttgtata agtacatctt
    11941 caagagttgg aactggaaat atagctggaa tagcaattgc agtggtagca ggaggacctg
    12001 gtgctgtatt ttggatgtgg cttatagcat taattggttc tgcatcaagc tttgttgaga
    12061 gtacattagc tcagatttac aaagtgaaag atggtcaagc ttttagaggt ggaccagcgt
    12121 attatatgga acaaggtcta aataaaaaat ggatgggtat tttattctca atacttataa
    12181 ctatatgtta tggttttgta tttaatgcag ttcaagcaaa tactgtttca cttgcattta
    12241 ataatgcatt tggaataagt aaaatggcta tgggaatagg tcttggaatt ttaactgcaa
    12301 tagttatttt tggtggagtg catagagttg caaaagtttc tgaaataata gttcctgtat
    12361 ttgcaggatt atatatatta gttgctttgg ctatagttgt aatgaatata acagagatac
    12421 caagtgttat agcattgata gttgaaagtg catttgattt taaaggaatg gcgattggta
    12481 catttatggg agttgtaatg actggagtga agagaggtct attttctaat gaagcaggta
    12541 tgggtagtgc tcctaatgct gctgcaacag cacatgtaac tcatcctgta aaacaaggtt
    12601 taattcaatc tttaggtgtt tttacagata ctataataat atgtagttgt acagcattca
    12661 tggtattatt atattcaggt tatagtagta gtggagcaac tggaattgaa ttagctcaag
    12721 aagctttaac tcatcatata ggaccagttg gaaatatatt tatagcagtt tgtatattct
    12781 tgtttgcatt tagttctata gttggtaatt actattatgg tgaatcaaat atggagttta
    12841 tgagtggaag taagactaaa cttaatgtat ttagagtttt tgttgtaggt atggttttat
    12901 ttggttcact tactcaagtg gatgtagttt ggaatcttgc agacttattt atggcattga
    12961 tggcgataat aaacttaata gcaatagcac ttttaggaaa atatgcattt attgctttaa
    13021 aagattatac aagtcaaaaa aaatcaggaa taaaagaccc tgtgtttatt gcagatgaaa
    13081 tagaaggcct agaaaaggta tcagagtggc atagggaatt atctgaggaa catttaggat
    13141 aaaaaatagt ataaaattat aaaaccattt tgaaagacta gagtatgtat atactttata
    13201 tgaatataat attgaattaa tttatattac tggaattttt aattccagta atattttttt
    13261 attatataat ttagctttat taaaagtttt tattattaaa aatagcttat ttatcgtaaa
    13321 gtgaatgata ttgggtttta attattatga atgttagtat ttaatttaaa gacttaaata
    13381 aatttgccat ttctagcgca ttcatagcac aatcataacc tttatttcca gcttttgtac
    13441 ctgctctttc aatagcttgt tcaatatttt ctgtagttac gattccaaat ataacaggta
    13501 attcactgtc taaagatact ttggctatcc ctttagagac ttcactacat acataatcat
    13561 aatgagaagt agcccctctt ataacacagc ctaaacagat tatagcatca tacttaccac
    13621 ttttagccat tttttgagca acaagaggaa tctcaaaagc tccaggtacc caaactattt
    13681 ctatattttc tggagaaacg tcatgtctta aaagacagtc ttcagctcct gataaaagtt
    13741 ttgatgttat aaattcatta aaacgagaat ttattatacc tatttttaaa tcttttccaa
    13801 taagttttcc ttcatatatc atttttactt cctccaattt tatttatgtt atagatttat
    13861 atttataaat atctttaatt taattataaa aaactactta gtagaaaaat atcatcatat
    13921 aatcatttat ataatatcta aaagatgtcc cattttatct tttttagttt ttaaatatag
    13981 cttattaaag tcattaattt cttcattaat agggattcta ttttcgattt ttattccata
    14041 tttctctaat tgatttattt tatctgggtt attacttaaa agatttatac tttttatgtt
    14101 taaatttttt aatatttgag cagccatata gaaatctctc atatcttctt caaatccaag
    14161 cattaaattt gcttcaacag tatcgtaacc ttcttcttga agtttataag ccttaatttt
    14221 atttaaaaga ccaatacctc taccttcttg cttcatataa attaaaactc cacttccatt
    14281 ttccacaatt ttcttcatag aagattctag ctgtaatcca caatcacatt ttagagagtg
    14341 gaacacatct cctgttaaac attcagaatg aagtctaact agagtatttt ctatatttat
    14401 atttccataa gtaagggcaa tgtgttcttc atttgaataa gtatctctat atcctatgat
    14461 ttcaaaattt ccatattttg tcggaaggaa agcactagat actttttcta tagtagtttc
    14521 atttattttg cggtattcta taaggtcttt tatagtgatg atttttaaat tatgcttttc
    14581 tttgaaaatc attaaatcat caactcttgc cattgtacca tcatctttca ttatttcaca
    14641 gataagacca atctctttaa aacctgcaag tctagcaagg tctactgagg cttctgtatg
    14701 tccatccctg acaagaaccc caccagtttt tgctattaaa ggaaagatgt gaccaggcgt
    14761 tttgaaatct ttacttgtag aattttcatc acagaataat tttacagttt cagctctttc
    14821 atatgcagat ataccagtta gagtatctgc tccatctata gtaacagtaa aggctgtttg
    14881 aaatgtatct gtattttctc taaccataag aggtatatta agacttttaa attttttttc
    14941 agtggcaggt agacaaatta gacctctacc atatgtagcc ataaaattta ttgattcagg
    15001 agtagccatt tcagctgcca tcaataaatc tccttcattc tctctacttt catcatcaac
    15061 cacgattacc attttcccat tttttatatc ttcaatagct tcttcaatag tattaaacat
    15121 gtaattcact cctttattat ttttaaaaac catttttaaa taaaaaatct ttatctatat
    15181 ttgatttatg gttattacta ttagaattta attccttgta gttattagcc ataaaattat
    15241 taacatactt tccaattaca tcgctttcta aattaacgaa atctccaaca ttctttgtca
    15301 agagaatagt gttaatttta gtatgaggta taatagaaac cttaaatatt tcatcatcta
    15361 aatatgatat agttaaactt acaccatcaa tagcaacaga acctttgagt atcattgagg
    15421 ataaaagttt tttatcaggt cgtatactta ctaaaactgc attttcatct ttttcaaatt
    15481 tgcagatagt tcctttacca tcaacatgac ctgttactat atgaccacca aatcttgaag
    15541 aaagactcat agctctttca agatttacct tgtcatttgc atttaataaa cctaaatttg
    15601 tggaacgaat tgtctccatc ataacatcgg ctgtaaattc attttttccg aggtttgaaa
    15661 cagttagaca aactccattt acggctatac tatctccaag atttgtgcca tctaatattt
    15721 tatttgatag tatggttact tttccactct taccattagc agtaattttt ctaagtattc
    15781 caacttcttc tactatgcca gtaaacatcc taacctccta tatgaatgta ttaacaaaaa
    15841 tttaatttaa aacatctgat tctataagaa tatcgccatc tatcaaagtt acattattga
    15901 ttgttaactg tgttgaatct gacaaatgat ttattccttc tccagaaacg aatgtaggtg
    15961 catctttacc acctataatc ttgggtgata gaaataattt gaccttatca actaacttat
    16021 ttctaaagag actgtcattg agagtagcac caccttcaac tagaacagaa tcaatgttta
    16081 actctcctaa tttatacatt acaaactcca aatctactaa gttgtttttt gaaggagaaa
    16141 ttattgtttc aacattattt tcttttaaca tagataattt tatactttct ttgcaacatg
    16201 tgaaaactat agttttactg gttttatctt taaccaaatt actattaagt ggcaacttta
    16261 ggtgtgtatc tattactatt cttgtaggat gagacacttt ttcttgattg agcctacaag
    16321 ttagtaaagg attatcgttc aaaactgtat ttatgccaac cattatactt tggtatttat
    16381 ttctgtattt atgagttaga taccttgatg attcattaga tatccatttt gattctagtg
    16441 attttgtagc aattttacca tctagactta ctgctgattt tacaatacaa agaggtcttt
    16501 tgttttttat atgataaaaa aatgcctcat ttaaatctct tgcttcatct tctaatattc
    16561 ccacagtaac atcaatattg ttatctttta atttttttac tccattacca caaacaagtg
    16621 gatttgggtc taatgtagat attacaactc tcttaatctt attttgtata attttatcta
    16681 cacaaggagg cgttttccca taatgagaac atggttctaa gtttacataa agagtagagt
    16741 cttttagact ttgtttagca ctgtttatag catttacttc agcatgatta gagccaaatt
    16801 tctcatgata tcctttgcct attatattac tagctttaac aattacacac ccaactaatg
    16861 gatttggatt tacaaagcct tctccatttt tagccaattc aatagctttt ttcatataat
    16921 aaatatcttt ttctttttga ttcacaaaat tcacaatatg tacacctcct gtttaattgg
    16981 ataattttta aacaaaaaac cctgagaatt aactcagggt ttagaataat ctacaataaa
    17041 tgtttaataa atgtagaaca aaattgctct acaaaaacac tcattaaata tcttcttcca
    17101 tccagacttt actgtcggct ttggaattta accaaatcaa ccaagtttta ccttggctcg
    17161 cgggctatac cgccgattgg gaatttcacc ctaccccgaa gattaagtat taaatttata
    17221 tttagaatgt atcataaatt attttacttt gcaaactatt tttttaaaaa atatatgtta
    17281 atatataata tagaatgtct ataaactttg aaataccacg attgtgaata taaaaataaa
    17341 aatttgaaca taatcaggaa agaagtctaa ttaatttaaa ttaggagagt aatatatgaa
    17401 taaaaaactt ttagaaatac tatcaaaata ctatggatat acaagtttta gaaaaggtca
    17461 agaatctata ataaactcta tcttaagcga aaaagatgtg ttagctatta tgccaacagg
    17521 agggggaaaa tcaatatgtt atcaaattcc agctttgatt ttagatggaa tgacaatagt
    17581 aatttctcca cttatatcac ttatgaaaga ccaagtagat gccttaaaga ctatgggaat
    17641 tagtgctgct tttataaata gttcattaag tagcaaagaa tttaatgaaa tattaaataa
    17701 tattagaaaa aataattata aaatactcta tattgctcca gagagattag atgcacaaga
    17761 gtttattgag ctaataaata ataacaatgt aagtcaagtt gcgatagatg aagcacattg
    17821 tgtatctcaa tgggggcatg attttaggtt gagttataga aggatttctg attttataaa
    17881 aaatttgcct aaaagaccta tagttacagc atttactgca acagcttcag aagaggtaag
    17941 aactgatata ataaatttac tgtgtttaga aaatccagat tattatataa ctggatttga
    18001 tagagagaat ttatcaataa atatagtaaa atcatctagt aaaaataagt atattttaga
    18061 ttatattcaa aatcataaaa atgagtctgg aattatatat gttgcaacta gaaaggaagt
    18121 tgaaaatata tataatggtt tatctaagag aaatatatct gtgtcaaaat atcatgcagg
    18181 tttatctaaa aatgaaagaa gtaaaaatca agaagatttt ataaatgata atgtggatat
    18241 aatggtagca acaaatgcat ttggaatggg tattgataaa cctaatataa gatgggttat
    18301 acattacaat atgcctcaaa gtatagaaaa ctactatcaa gaaataggta gagctggtag
    18361 ggatggagaa aaaagtgagt gtgtactttt attttctcca ggagatgtac atatacaaaa
    18421 atatttaatt gatattggag ttgaaaatcc tgaaagaaaa ttatttcagc ataagaagct
    18481 tcaatacatg attgacttag tttacagtaa ttcatgctat agaaagacaa tattgagtta
    18541 ttttggagaa aattatatag acaattgcaa taattgtagc aattgtttag tagagggtga
    18601 aatagtagat aaaactatag atgcacaaaa agtcatttca tgtgtagcta gaatgaaaag
    18661 aagttatggt gttactacta ttgtagatgt gcttagaggt tctaagaata aaaagatttt
    18721 acagcttgga ttaaatactt tgtctacata taacattatg agagattatt ctagtgaaga
    18781 cttaaagaat tttgtaaata cattggtttc tcatggtttt ttagatttag ttgagactct
    18841 aggcaatgga aatagaggta gttttcctac tataagatta aatgagatgt ctatgaaagt
    18901 tttaaaaggt gaagtgaaag tagagtttaa agaaattgtt atgacaaaat cattggaagt
    18961 agaggatgag ttatataatg ctttaagaga acttagacat tcaattgcaa gtgaagaaag
    19021 gatagctcca tatatggtat ttggagatgg tacacttaga gccatgtcta gtagttatcc
    19081 aattaataaa gaagaaatgc tagatatctc tggagtagga gaaattaaat atcaaaaata
    19141 tggtagagat tttgaagcag taattaaaga atatgtcgaa aaaaataata taaataaaaa
    19201 aatagatgaa aaaaatgtcg attcaaagaa cgttaatagt gatttcttag aggttaatac
    19261 agataaagtt ttatatgaaa aactgttagt cattagagaa gaatatgcaa caaaggaaaa
    19321 attacctgca tatatgattt tagccaataa ggctttgaaa gaaataagtg gaagatatcc
    19381 acttgatgaa gaacaattaa aagatatttc tggcataggt ggagtaaaat ttgaaaaata
    19441 tggagctagt attttggcag aggttaataa atatgtaaaa gaaaataata ttaatgttat
    19501 ttgggagaaa aagggcaaaa ggaagttaat attagatgga gaaagtagaa aaaataatga
    19561 aatagcatta gatttgctaa atcaaggaaa agatatacaa agtatcagtc aagaaataga
    19621 agtttcactg tcaaccatta ttggatatgt gcatgactat gtaaaggatg gacatagtat
    19681 atcatttgaa ttaggactag aaaattttta taatgaagat aaaaagaaga tgattttaga
    19741 agtttgcgaa aaagttggct atgataattt aaataacata aaaagaaaac ttccagattc
    19801 aataaagtat gaaaatataa gagctgtgat acttgactct tatcttgaaa acttaaaaaa
    19861 taatattata gcagagtaat ttttaactta ataaaaaata aaatttgtat tattgtgttg
    19921 aactaataat tttgctgtgt tatactgaat ttgtaaaaat aatgaaaaat tagagctagg
    19981 ggcgctagaa ttggctagct gagagataaa gccgtaactt acaaacccta ataacctgat
    20041 caagataatg cttgcgaagg gaagcttttt aatataattt tattatataa ataggcaaat
    20101 tattcaatgt taggagaaat ttgtctaagt gtatatacga ttataagagt gctttccaaa
    20161 cgaggaaaag cacttttttt attttcaaaa actataactt taatcttgga ggattgtaat
    20221 atgaactata caacacaaat ggatgctgct agaaaaggca taataactaa agaaatggaa
    20281 atcgtttctc aaaaagaaca ggtagatgta aatgaattaa gagaattaat agcaaatgga
    20341 caagttgtta taccagctaa taaaaatcat aaatctttaa gtgcagaagg tgtaggtaaa
    20401 aatttaagaa caaaaataaa tgtaaatcta ggaatttcaa gagattgtaa ggatatagaa
    20461 aaagaacttg aaaaagttag agtagcaata gacatgaaag ctgaagctat aatggattta
    20521 agtaattatg gcaaaactag agaatttaga gaaaaggttg ttgaaatgtc acctgcaatg
    20581 ataggttcag tacctatgta tgatgcagta ggatatttgg aaaaagaatt aaaagatata
    20641 acagaagaag agtttttaaa tgtaataaga caacatgcta ttgatggagt agactttatt
    20701 actatacatg caggtcttac aagaagtgtt tgccaaaaaa taaaaaatca tgagagattg
    20761 actcatatag tatctcgtgg aggttcttta ttgtttgcat ggatggaatt aaataataag
    20821 gaaaatccta tttatactaa ttttgataaa atattggata tatgtgaaga atatgatgtt
    20881 acattgagtt taggagatgc ttgtagacca ggttgtataa aagattctac tgatggtgtt
    20941 caaattcaag aacttgtagt attaggtgaa cttactaaaa gagcatggga aagaaatgta
    21001 caagtaatga tagaaggtcc tggacacatg gctattgatg aaatagaagc aaatgtagta
    21061 ttagaaaaga gattatgcca tggagcacct ttttatgttc ttggaccatt ggttacagat
    21121 atagcaccag gttatgacca tataacaagt gcaataggag gagctttagc atgtgccaaa
    21181 ggagtagatt ttttatgtta tgtaactcca gcagaacatt taagattgcc taatttagat
    21241 gatatgaaag agggtataat agctgcaaag atagctgctc atgcaggaga tatagctaaa
    21301 aatgttaaag gtgctcgtga atgggataat aagatgagta aagctagagc tgatttagac
    21361 tggtgtgaga tgtttagact tgcaatagac cctgaaaaag ctaagagata cagagatgaa
    21421 tcaactccta ctcatgagga tagttgtact atgtgtggaa aaatgtgctc aatgagaaca
    21481 gttaagaaaa tattaaacaa tgaggaactt aatctaatat aatttttggc tagtatgact
    21541 ggaataaaaa taagctgaaa agaggaggtg atttagtgaa ggttaatggg aaggaaattg
    21601 aatttgaaaa agatttgact gttatagatt tattaaataa atataattta aaaagtgata
    21661 gagttgtagt tgaagtgaat ttagagataa ttgaagaatc taactacaat acatatgtat
    21721 taaaagacga ggacattgta gagcttatta gctttattgg aggtggttaa aataaaaata
    21781 tttgtaaatg aattattaac agatgttgag gaaaatacaa ctgcttataa agttagagat
    21841 agctataaca ataaatgtga tgtattggtg ttaaatggat atccaattaa aacagatatg
    21901 accctttgtg aaaatgataa attaacactt atacaaaaag gagttaagcc atcacttgat
    21961 gaattggaaa gcttgttgat tgctagacat actccaaata tacataataa attaaaaaaa
    22021 gggaaagttg ctatattggg attgggggga cttggttcca atatagctat ctctttagct
    22081 agaataggag tgggagaact tttacttata gattatgatg ttgtagaacc atctaattta
    22141 aatagacagc agtattttat agatgatata ggaaaactaa aaactgatgc catgatagaa
    22201 aatataaaaa aaataaatcc atttataaaa ttaaataaac gagatatttt tttaaacaag
    22261 aacaatatgg atactattaa ggattcagat ttaataattg aggcctttga tgatgcttca
    22321 tgtaaagcac aggtatgtaa ttatgtatta ataaatttaa aagataaata tttaatagca
    22381 tcatctggta tggcaggtta ctatgattca aatataataa ctactaagaa gataaaagac
    22441 aggttttata tatgtgggga ttttgtgaat gaagctaaat ttggtgaagg gcttatggct
    22501 ccaagggttg ccatctgcgc aaatcatatg gcaaatttgg caacgcaaat acttatagat
    22561 atgtaaatat taaaattaga tataaaaaag attgaatatt aaaaaaattt aacgtggagg
    22621 gaaataatat ggataaattg gtacttggtg gacatgaatt taatagcaga ttattggttg
    22681 gaacaggtaa atatggttca aataatatat tgcctgaggt aataaaagaa agtggaagtg
    22741 aaataataac aatggcactt agaagagtgg atttagacaa taaacaagaa aacatattaa
    22801 cgtatattcc aaaagagatg acaatacttc caaatacatc aggagctact aatgcagaag
    22861 aagctgtaag aatagctaga atatctagaa aaatgggatg tggagatttt ataaaaatag
    22921 aagtaatatc agatactaga tatttacttc ctgataatga agaaactata aaagctacaa
    22981 agatacttgc tgatgagggg tttatagttc ttccatatat gacaccagac ctttatgctg
    23041 gaagaagact tatagaagct aatgcagcgg cagttatgcc acttggagct ccaattggtt
    23101 caaatagagg tcttcaaatg aaagaaatga taagaataat gatagatgag ttggatatac
    23161 caataatagt agatgcaggt attggaaaac catctcaagc tatggaggct atggaaatgg
    23221 gagctgatgc agtacttgtc aacactgcta tagcttcagc aggagaccct gtacaaatgg
    23281 ctagagcatt taaattagct gtagaaggtg gaagagaagc atatattgca aaaacaggaa
    23341 atgtgtcaga atttgcaaat gcatcttctc ctttaacagg ttttttaggc aatttataga
    23401 aagtggtgat tggtgatgag tttttatgat gtaatagaaa aatataggga ttttgatttt
    23461 gatggatatt taaataatgt tactgataat gatgttttaa gaagtttatc aaaagacaag
    23521 cttgaagatt ttgatatatt aaatttgctt tctaaaactg cagtaaaaca tttagaagat
    23581 atggcacaaa aagcacataa attaagtgtt caatactttg gtaaaacagt atgtttatat
    23641 acaccaatgt atatagcaaa ttattgtgtt aatcaatgtg tttattgtag ctataatata
    23701 aagagtggaa taaaaagaaa aaaattaact atggatgaaa ttagagaaga gggagaagta
    23761 atttcaaaag aaggtttcaa acatctactt gttttgactg gagaaagtag ttttcactca
    23821 agtgtagaat atataggtga ggctatagaa atattaagag agaaatttcc ctctataggt
    23881 atagaagttt atccaatgga agtagaagaa tataagtaca ttgtagataa aggtgttgaa
    23941 ggattaacag tatatcaaga aacttatgac gaggaaatat ataagagagt acatataaaa
    24001 ggcccaaaat caaattataa atttagacta gatgctcctg aaagaggggc aaaagcaggt
    24061 atgaggactt tatcaatagg tgcactttta gggctaaatg attttagaaa agaaactttt
    24121 tttacaatat tgcatgggaa atacttaaaa acgaaatatc ctcatattga gctttcatat
    24181 tcaacaccaa gaatgagacc ttttaaaggg tgttttgagg aattggtaga tataagtgat
    24241 actgatttag ttcaagctat ggtatgtatg agattatttg accctcatgc agctataaat
    24301 atatccacta gagaaaattt agaaatgaga agtcatataa tacctttagg agtaactaaa
    24361 ttgagtgcag gtgtatctac tgatgtagga ggtcattctc aagatgaaca tgatactgct
    24421 caatttaaga taaatgatga aagtactgtt aaagatgtgg agaaaatgct aaactcaatt
    24481 ggttatcagc atgtgtttaa agattgggaa agattttaaa tgtatctgat aacaaacaga
    24541 aaattatgta gtgaggaacg atatttagaa gttattaaag agtctatatt gagtggtgta
    24601 gaaaatataa taataagaga aaaggattta gaatatcaag agctaagaaa attatatatg
    24661 aaaataaaaa ctaaaatcaa ttgtatagat tttcaagagc aaatatcaga tgaaagtttg
    24721 aaaactaata taaatcaaaa agagtttaga aataaattca aggttaattt tataataaat
    24781 agtaacattg aattttttga aaaagtggat tgtcaaggta tccatcttcc ttttaaatta
    24841 ttcttgaatt taattgaaaa taagtataat tttaatgaaa ataaaatact aggattatct
    24901 ttacataaag tagaggaagt agattattta gaaaaattaa taagaaatca aaatataaaa
    24961 atagattaca taacattatc acatatatat gaaactaaat gtaaagaagg attaaatcca
    25021 aaaggaattg agcttttaaa agaagctaaa aagattactg atattaaaat aattgcactt
    25081 gggggaattt taccatctaa tgtcaaggaa acattaaaat actgtgatga ttttgctata
    25141 atgtcaacta taatgaggtc taaagatatt aaaaaaacca tatcaaatta taatgaaaag
    25201 ttgaattagt aaatatagta tattgaattt ttaacttaaa taaaaataaa aaagttatct
    25261 tttaaatttt aaaaggtagc ttttttattt tatatctttg ctaataaaaa attgtaaaaa
    25321 gggaaaactt tagtcagaga gattaaacaa tatcctagaa agatttaaaa tttagtaaag
    25381 tatggaggac attataatga ctgacagtaa aaagaaacga tttattatac cacacacttt
    25441 tacaataata tttttactaa tagtcttgat ggcaatattg acttggatag taccaagtgg
    25501 tgaatttagt agagaagatg tagaaggtag aatggtagtt gtaccaggga cttatcaaag
    25561 tgtagaaagt aatcctcaag gatttgcaga tgtttttaaa gcaccaatag aaggctttat
    25621 cgattcagct gaagttgtag gttttgtttt aatagttgga ggtgcttttg gtattgtaaa
    25681 taggactgga gctatagaag caggaatagc ttcggttatc tctaagttta agggaaaaga
    25741 acttcttata attccaatat caatgatttt atttggactt ggaggtacaa catttgggat
    25801 ggcagaagag acattaccat tttatatgat atttgttcca ctcatgacat ccttgggata
    25861 tgattctcta acagcaatag caattgtatt tataggagca gcagcaggag cagccgcttc
    25921 aacaataaat ccattttcag ttggtattgc acaggcacta gctcaacttg ctcctggttc
    25981 aggagtaact tacagagtag ttatttttat agcatatata ctaataagta tagcatttgt
    26041 tatgtactat gctaagaagg taaaggaaaa tcctgaaagt tcaatagtat atgaaataga
    26101 taaaaataat aaatcaatac ttaatcaaac ttcaacagaa ataaaagaat ttacttttaa
    26161 agaagtatct gttcttgcta tatttggaat agggatggca ataatgattt ggggtgtttt
    26221 aagtcaagga tggtacattc cagaaatatc aatgtgtttt gctgcaatag gtgtgctttc
    26281 tggattggtt ggtagattat ctcaaattga aatctcagaa agttttatag atggagcaaa
    26341 agatttagca tctgcagctc ttgctatagc tttggctcgt ggaatcgtaa taattgctca
    26401 aaatggattt ataatagata ctatattaaa ttccgcagca gcctttctag gtgggcttcc
    26461 aaaggttata tttgtatatt tatcattttt cttggaagct gcattggcat ttttaattcc
    26521 atcatcttca ggtcttgctt cacttacagt acctgtactt gctcctcttg gtgatttggt
    26581 taatatatcg gctcaagtga tagtaaccgc ttatcaattt ggtgtgggtc ttacaaactt
    26641 tataactcca acttcaggag tactgatggg agcacttgca gtagcccata ttccattttc
    26701 aaaatgggta agatttataa tgcctatctt gttgattttg acagctgtat ctctagtctt
    26761 tttaacaata ggtatttata tagggtttta attaagtgta gttttattta agatatttag
    26821 taatggtata aaatgataat atgttttcaa taaattgcca ctaatttaat tagtggtaat
    26881 ttgttttttg tatttaaaaa taaatgtatt tacttgtatt ttgaattaat atctacttag
    26941 acattgtttt aattgttata tttttattta attaagcatt gatttatcat tttttatatt
    27001 tcatataaca atgcaaaaaa taatttttat atagtaaatg acaaaagttt acaataaatg
    27061 tatattttct tactcattcc ttaaaattac tcatttagtt taataactct catttcatat
    27121 gtaaagttgg taaaaaaatt aaaattaaaa gtaaaaaact aaataaatta atgttaattt
    27181 gaaatatata tgaaggtttt tggagaatac ttacttatga taggaaaaaa tgttaaaata
    27241 atagtgtaat caaatataaa ggactgaaat aattaacagt tattaaatat taggagtgta
    27301 aaaatttatg ggattaaaag aatttgattt tattgaagag tctattgata tgttgaggac
    27361 aatgtcacca acattagaaa ctatatcaga tgaaatagaa gaatattttg aaaatatctt
    27421 ggatgaaaag aatcaagaat atataaatgt aacctctaga ataaaatcag aatcaagttt
    27481 aagagaaaag ataattagaa atagatattt aaaaaaatat ggagaagcaa gtaatcttat
    27541 tcataatgtt tctgacttaa taggcctaag aattgagtgt agatttattg aggatgaaaa
    27601 caaaatatat agacttttga gaagatattt taataaaaca gatgacaaaa taaactatta
    27661 taataaagag aataagaata ttaaattaaa actatctgag aggcaaccca ataagcaaaa
    27721 aaatggattt gaaatatata aaatagatgg agtttttgcg tatttagata gagaagtaaa
    27781 atttgaactt caaattaaat ctcttgtaaa tgtgttttgg agtgaaatag aacataaaat
    27841 aatttataaa aacaatacat atttacttgc tgataaattt ataaaggata tgatggactc
    27901 tataaagaat aatcttacta tgatagataa tcagctttta agtatttata aaaactttca
    27961 ttcagggaag tcttttaata tgaaagtaag taaaaaagaa attgaaaaat tatttgcgaa
    28021 actagtctat gacgcttttt ctgaaaagat gaataaaagt ataggttttg ttgtagattt
    28081 taaaaaacca tgtgagacta tattgaacta ttcttttaat aaacaagata taagtgatga
    28141 agttttaggt aattttatgc ttgatgagtt tgcaagatta aatgaaattg taaacaagga
    28201 tatagatttt aatgagcaaa tagaatttga aagagaacca acatttgatg ataagttttg
    28261 taaagaccta ggaaatcatt ttagaagtag attaaacaca gaatttccat ggaacctatt
    28321 ttttagaata ttatttgaaa tagagccata taacaatacc aaagactttg aaaactttgt
    28381 agagtttata aaagaaaatg tgctactaga agaaaatagg gagcaattat tatgccaatt
    28441 tgaagaggat agtaagctta taattgaaga tatatatgat tgtatattta atagtataag
    28501 tgagattgat agtgttgaaa ttttatataa ctataatctt gaaaaaataa actttacatc
    28561 aagtgaaatc ataaattgta tatgtagaga atatgagtgt tatggtgaat acttagaaga
    28621 aaaagaaaag cttatgaata catttaaaga aaagattatt caaatctttg agtaataggt
    28681 caatgctgaa gtggcgctaa tgcgccattt ttcaaatata tatgaattaa gtaaaattat
    28741 tttggaggag gcgatttgta tagagaaaac aggtgtaatt ttggcagggg gaaaaaattc
    28801 tagaatgggt agagataaag cctttttaga gttacatgat aagcttttta ttgaaattgc
    28861 aatagaagca tttaaaaact ttgatgagtt gataataata tctaacaatg aagaattata
    28921 ttctaaatac gatattaaag tttataatga tatagtaaaa gatgttggtc caattggagg
    28981 aatatatact gctcttgaat atgcaaagta tgatatagtt acaattgcat gtgatatgcc
    29041 atatctaaat aatcaaatag tcgaaagaat agctaataaa atggatgata aaagtgtgat
    29101 ttcagtgaca aatggaaagt tacaaccatt gtgttctgga tataaaaaga gtataataaa
    29161 taaagtatct ttatgtataa gggaaaatga tttaaagctc agaagcttta tagataaaat
    29221 agataaaagt tatatatact ttgatgaaga agatttattt ttaaatgtaa acactgttga
    29281 tgagtataaa aaattaacta aagtttaatt agctatggtt gtaaaataga gtaggattta
    29341 tatggaggag agtttatgaa tttacttaaa tgcgattctt gggcagtaat attaaataat
    29401 agcgataaag aaagtaaagc atataaaata ttagatgaac ttaaaaggaa tatgtacaaa
    29461 gttgttgcta tagatgaaga gaaaaaacct attgaaggaa tagatgtgta tgaatgttta
    29521 aaagatgttc cacacaatat tgatgttgta gctattattg ataaacaatc taagatggat
    29581 gtgattttag aagaagtaga gcttttggat atacaaaata tgtggtttga aaaaggaagc
    29641 tttagtgaaa tgatgattaa aaagactaaa gatttaaaat taaatataga atataattta
    29701 agtttatatg atgagttgac tagataaaat tatatttctt aataataaaa atataattag
    29761 ttaataaaac atattatttt atagtataga ttggttaata aaagtacaga ttggttaatg
    29821 aaacattaaa ttacaatatt tgttaaaaaa attgtgagtt acatgatata atgtattaaa
    29881 taggatacta aggagttgat atattatgtt aatagtaact acagaaaaag tagaaggtaa
    29941 aaagatatca aaggttttag gattagtgag aggaagtaca ataagagcaa aacatgttgg
    30001 aaaagatata ggagcaagtt ttaagaatct tgttggagga gaacttactg gatataatga
    30061 aatgctcact gaagcaagac aaattgccat aggtagaatg gttgaagatg cagaagctaa
    30121 aggtgcaaac gcagtaatag catttagact gtcttcagct tcagttatgc aaggagcagc
    30181 agaaatgctt gcttatggaa cagcagttgt tttagaagat gataatagta ttcttgaaaa
    30241 ataaaatata aatagttaaa aagaggcatc ttttaaaaat tttatggatg ccttttttta
    30301 tttgaaaaaa ctaatttgag aagaaatttt aactattatg acaataaaat tagggtgata
    30361 ttatataaat aagtaaaatt atattatata atgtatggta tagactttaa aaattttatt
    30421 tgtagagaaa aatatggaca atgttataat aattatagaa attaaaagta cttacattca
    30481 ttatgtatgt gacatgtata attagtttta tatttaatac agttttgaag taatatcttc
    30541 attttgagaa cgttggaata ataaaaaatg tattattata ggtgatataa ataaaaaata
    30601 aatataatat gttatattgc tgatagaaaa gagaataaaa gaaaataggt tttattaaaa
    30661 gagattttta tttataggac ttaatcaatg tatagagggg tgagaacata tgtttaatgt
    30721 tgcaattata acacttagtg ataaaggata tgaaggaaaa agagaagata taacaggaaa
    30781 aaagttaact gaatttgttg aaaatacagg agtttataaa gttactgaat atgtacttat
    30841 aaaagatgat aaggaaatgc taaaggaaaa tattataaga ctttgtaata gtaataaaat
    30901 agatttaatt cttacaaatg gaggtactgg tttttcaaaa agagatataa ccccagaagc
    30961 aactaaggaa gtgttggaaa aagaaatacc aggtctgagc gaatatatga gaatgaaatc
    31021 cacagaaatt actaaaaagg ccatactaag taggggtgtg agtggaataa gaaataattc
    31081 tataataata aatttacctg gaagtcctaa aggtgcagtt gaaaatctaa gttttataat
    31141 tgatgtttta gaccatggca tagaagtttt aagaggagaa gctacagaat gtgccactaa
    31201 aaaaagtgaa tagtatataa tctagataga taaaaaatag acaaagaggt agataaagta
    31261 tgattgataa gtatggaaga aaaatagact accttcgtat ttcacttaca gataagtgta
    31321 atttaaggtg tgtctattgt atgccaccag atgtaaaatt tgataaaaat tatataaatg
    31381 aaaatctaag ctttgaagac tacaagttta ttataaaggc tatggctgaa caaggtataa
    31441 caaaaattag atttactgga ggagaacctc ttttatatcc taaattaaat gagcttataa
    31501 aatttacaaa agaagaatgt ggaataaata acataggaat gaccactaat gctattggtc
    31561 tttctgatag aatttttgag cttgaaaaat gtggcttaaa taaagttaat ataagtttag
    31621 attctttgaa ggaatataag tataaatcca taacaagagg aggaaactta aaagatgtct
    31681 taaaatcgat tgaatcttgt ttaaatttag gtataaaagt aaagttaaat tgcgttgcta
    31741 taagtgggtt taatgatgat gagcttaaag attttatgtt tttaacagtt aaatcaccaa
    31801 ttgatgtaag atttatagag cttatgccat taggtgaggc taatagagtt tataagaagg
    31861 gttattttaa tgtaaaagaa atgattgaaa aaatatatgg tttatataaa gtcaaaaatg
    31921 atgaaaaaag tacagcagaa tattatatgt ttaaaggagc taaaggaaga ataggaatta
    31981 taactccatt aagctgttca ttttgtaaca cttgtaatcg tattagactt acttctagtg
    32041 gtgcaataaa attatgtcta cattcaaaag aagaaataga tataaaacca tttttacata
    32101 aaccattgtt atttagagaa tctatgaaag atataataaa acaaaaacca gaaaaacatc
    32161 atttaataga aaataaatgt agtgatacaa ataggcgtat gtatgaaatt ggaggataag
    32221 taatgttaac acatataaat gaaaaagggt atgccaagat ggtggacata agtgaaaaag
    32281 atgatactaa aagaacggcc gtagctacag ctacaattac tcttagtaag gaagcattag
    32341 aaaaagtaaa aaatggtcag ataaaaaaag gagacgtatt gtctgtagct caagttgcag
    32401 gtataatggg agctaaaaat acatcttcaa acataccaat gtgccatcag attaaattag
    32461 ttggatgtga tttagaattt gatgtagatg attctatgtc tgctattaag atatacgcaa
    32521 cctgtaaatc tcttgggaaa actggagtag aaatggaagc tttaaatgca tgttctttag
    32581 cagcacttac aatttatgat atgtgtaaag cagttgataa aaaaatggtt ataagtaata
    32641 tccatcttgt ggagaagact ggtggaaaat caggagattt taagttcgag taaattaata
    32701 atatattggg ttaaaatttg gaggaaatat ggcgaaggta gtgtcaataa atataagtga
    32761 gaaaaagggt gtaattaaag ttcctgtaca atgtgcagag ctaaaaataa atcatgggat
    32821 agttggagat gcacatgcag gaaactggca tcgtcagata agcttacttg gaaaagaaag
    32881 catagataaa atgaaaatga aaggctttga ccaattaaaa tatggagatt ttgctgaaaa
    32941 tgtaactaca gaagggatag aagttttttc cctgcctgtt ggtacaaagt taagaatagg
    33001 gcaatgtgaa gttgaagtaa ctcaaatagg gaaaaaatgt cacaatggat gtgaaattaa
    33061 gaaattgaca ggtgactgtg tgatgccacg agaaggaatt tttgtaaagg ttctaaaaga
    33121 aggaattata aatgtgaatg attcaataga tgtaatctaa tgaagtcact attaaaatat
    33181 aattataagt aaatactatt aagatttaaa tatatatttt aagagagaat taattttaat
    33241 aaaatatttt a
//
LOCUS       DAEQCW010000036        32466 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.036, whole genome shotgun sequence.
ACCESSION   DAEQCW010000036 DAEQCW010000000
VERSION     DAEQCW010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 32466)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32466)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32466
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.036"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(280..1119)
                     /locus_tag="KRO40_001698"
     CDS             complement(280..1119)
                     /locus_tag="KRO40_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH2092519.1"
                     /translation="MSDIKNEVSKKTLSKKDVIKSWLRWFFFAQSNYNYERLQSTAFS
                     HSMLPVLKKLYPDKEELKQEVETHLAFFNTEPICGCVIHGITIAMEEEKANGADEISG
                     DGMNAIKTGLMGPLAGIGDTLTQGVITPIVLAVCIGLTEGGASIAGPILFVIAQYIIM
                     TSISFGMWTNGYKYGKKAVESILQGGIVNKVIEGASILGTLVMGGLVGRFINLSTPIS
                     YTSGDFKFSLQTDLLDKIFPGLIPLVLTLLVLFALKKGLSPIKIMFILIVVGAITGIL
                     GLF"
     gene            complement(1143..1901)
                     /locus_tag="KRO40_001699"
     CDS             complement(1143..1901)
                     /locus_tag="KRO40_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2092520.1"
                     /translation="MHISLIQAVLIAIFYYLSWSPWLTYVGFFTWNRPLLAGFVTGII
                     LGDPVQGAIIGAGINMIYLGFISAGGAQMGDPAFAGYVGTALAIASKLDVSTAMAIAV
                     PLGTVATVLWIGKMTVNSFFAHWADREVQKGNVDRVAFINIVPPQILLFAMSFIPALL
                     VVYFGPNAIDGMLEVMNDNVLHVFNVIGAMLPALGIAMNLKLIGNKFTMPFFILGILM
                     AVYFKVDIIVISVIGVILALTITSIKYGKDSATS"
     gene            complement(1948..2421)
                     /locus_tag="KRO40_001700"
     CDS             complement(1948..2421)
                     /locus_tag="KRO40_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092521.1"
                     /translation="MSNIALTRIDDRLIHGQVITAWCKITSAKRIVIVDDLVVKDPFI
                     VQVLQMAAPSTVKVEVHDVESGAEVLKSYNGDENLIVLVKYPKTVLGLVNSGVDLKEL
                     NVGGMGAGLGRKSFYKNISVSDEEKEIFRELISKDIKCFIQIVPDAKKIDVGTLL"
     gene            complement(2450..2866)
                     /locus_tag="KRO40_001701"
     CDS             complement(2450..2866)
                     /locus_tag="KRO40_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092522.1"
                     /translation="MIHMAGIIIATHGNMAKAMLESAELIVGKQENVETLGLNHGDSI
                     DEFSRKLEDGIEKYKDEGVLVLLDFYGGTPFNTSAIIINKFAKVCELECLTGVNLPML
                     LELFLNRDTMKLKDLKNLCEEVGISGIKDVKTVLKL"
     gene            complement(2913..3965)
                     /locus_tag="KRO40_001702"
     CDS             complement(2913..3965)
                     /locus_tag="KRO40_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH2092523.1"
                     /translation="MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISK
                     YSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDRVAVCPAMPCFECNECKKGLYSR
                     CNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
                     VGDTVVVLGTGPIGLFSIQWAKIFGSTKVIAVDVFDEKLDLAKGLGADICINAKEKNI
                     VEEIKRLTDGDGADIVIESAGTPLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEK
                     IVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTHRINLEEVPAYFEKV
                     YKRDIFFGKIMINIDN"
     gene            4361..5041
                     /locus_tag="KRO40_001703"
     CDS             4361..5041
                     /locus_tag="KRO40_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBH2092524.1"
                     /translation="MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGENSVGL
                     SIDGIGRANLETSVKFFEILNNAGIKTHYVSANLEEATMEVLPAKVFGNGLEVICRYR
                     AVGSFLRRYGSCVEEGAKLDCYVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKS
                     MTQKISNIVRDTIAEKGLELYDIKFEFGFYNDEVILIDEIASGNMRVYKDGVIVDPMD
                     LTALLLDK"
     gene            complement(5174..5494)
                     /gene="sugE"
                     /locus_tag="KRO40_001704"
     CDS             complement(5174..5494)
                     /gene="sugE"
                     /locus_tag="KRO40_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000118520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quaternary ammonium compound efflux SMR
                     transporter SugE"
                     /protein_id="HBH2092525.1"
                     /translation="MKWLFLFVAGLFEVFWAFQLKNSHGFSKLTPSILTVVGMIVSFY
                     FLSLALKHLPLGTSYAIWTGIGTVGTAIVGMAILNEPISISRIACIGFIVVGIVGLKL
                     LSTN"
     gene            5876..6703
                     /locus_tag="KRO40_001705"
     CDS             5876..6703
                     /locus_tag="KRO40_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBH2092526.1"
                     /translation="MNFYKIAVCQMITTENKIENINHAVDMVTEAAINGAKIVVLPEM
                     FNCPYENKYFPKFAEEYPGETTTILSKLAEKHGIYLVSGSIPELEDGKIYNTCYVFDK
                     NGDLIGKHRKMHLFDIEVTGKVSFKESDTLTAGNDVTVIDTEYGKVGIAICYDIRFPE
                     LSRLMALKGAEIVILPAAFNMTTGPAHWELSIRMRALDNQIFYVGAAPARNMNASYIA
                     FGNSRISDPWGRIIAQADEKECIIYADIDRDLIPDIRQQLPLLKHRRTDLYELNTLK"
     gene            7525..8199
                     /locus_tag="KRO40_001706"
     CDS             7525..8199
                     /locus_tag="KRO40_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092527.1"
                     /translation="MNNKILVVDDEEGIITLLKDYFEMNSYEVYTAQSGKDALKKISK
                     NPDIILLDINMPEIDGIEVCNRIRDYVSCPILFLTARIENTDKINGFRAGADDYIVKP
                     FDLDELGARVSAHLRREQRKSNQTKIKFYNDLTIDYEKRLICIYNNQISLSKKEFDIV
                     ELLSMNPGQVFDKEKIYDRVWGYNSNGNSDVIMEHIRKIRIKLSKHTLENYIETVWGV
                     GYKWIK"
     gene            8187..9347
                     /locus_tag="KRO40_001707"
     CDS             8187..9347
                     /locus_tag="KRO40_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2092528.1"
                     /translation="MDKINNMSLKKAFFVLTLSSLIIASVLTTFAYILLNNLYNSIQD
                     KYLKTPINTGIITIVQNNVNQFSDYDKTLLNIINILQLVLPLIFFIGLLLLADIIFYK
                     VKLKTPIEILNKGAMEISNNNLDFCLEYNNNDELGNLCNAFEKMRSELNKNNIKMWTM
                     INDRKQLNAAFSHDLRNPLTVLKGYSNYLTKYIPTGKLSDEKILSTTQLMSDHINRIE
                     YYVENMSNAQRLEDLVVSKSMSNINKFIENLDENISIIAKQEGKSFTLKSQINNINLF
                     FDENIILRVVENIISNAFRYARNNVSILIYLEQELLTFVIEDDGIGFSKESLKLALRP
                     FYRDKTLNDSNAHFGMGLYISKILCEKHGGSISIENNSTNSAKITAKFSTRN"
     gene            9618..10091
                     /locus_tag="KRO40_001708"
     CDS             9618..10091
                     /locus_tag="KRO40_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="HBH2092529.1"
                     /translation="MLSSTFCSLPFWICYFWCGISDIFDGLIARKLRQQSGIGAKLDS
                     IADFIFSVTILVTVGKNIALPMYLWWCIVAIALLRLISYSIGFFKYRTFSSLHTLMNK
                     ITGISIFAFPLLYICFGLDVAGIMICIVAFLSSFEEIAIMIKSKELNRDIKSIFM"
     gene            10377..11045
                     /locus_tag="KRO40_001709"
     CDS             10377..11045
                     /locus_tag="KRO40_001709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092530.1"
                     /translation="MIIKAKQLSKIYGSNNNKVIALNNVNLEINSGEFVSVIGPSGSG
                     KSTLLHILSGLDNPTSGQVLLDDKDIYKHTEKELSALRRKSFGFVFQQFNLLPVLTAS
                     ENISMPVLLDKKQPDKEYLNEISSLLGIADRLNHLPHELSGGQQQRVAIARALIAKPD
                     IIFADEPTGNLDSKSGSEVMNLLIKTSKQFGKTLVVITHDDRIAKLADRKISIIDGVL
                     MEVK"
     gene            11048..13516
                     /locus_tag="KRO40_001710"
     CDS             11048..13516
                     /locus_tag="KRO40_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092531.1"
                     /translation="MKNYLSLSIKELKSQKLMTTFIIIAIVLSTIMTTVVGQSIGILQ
                     NLRIEQARSFNGDRHVSFHQLTKNQVDDIKKDDRVYQAGTSITLGSSKIKDSGISVLV
                     KEYDKTGLSNYPKLMKLKSGNLPKDKNEIALDENTLKLMGIKPRLGVTIPMNLDISLL
                     NDTIPPYNYTANFKLSGILEDDYTGYVSGIVNGIVGKGTSENLLPKRYILSSLDFKIK
                     QQEKFQEIVNQLAKKINLSHNSIQYNWIYLNALKIQFEKDENSSNSDGISMIILVSLF
                     VALLVLLASGLVIYNILKISVTKKIKEYGCLRAIGAEPNQIYKIVILQILILCTVAIP
                     IGAVIGIISSKGITGMVTNILNPDILLANDNKEITELIHKNTTAYMFPLVLSTNVSLI
                     FSFISALPSAIYASHVSPKIAMVGSTTKIKRKIKREKTIKNFERHLAWLNLKRNKGRT
                     IITILSLFMSITVFVALSEFSNVLDVSRSVSNLKEGDFSLTNEISGFDKSTLDKITKM
                     KNVNRTSFIKYSEYKQGEIDTDINFENSGEMLKIIGIDEQTLKDLMPSITDSILEDFK
                     NGSICFIKNPIAISTPGVKTRHTNLKPKDSITINKKQLDIYSTVDKMFFLQGNGWING
                     VDVIVYDSVYNTLTNKNKFNQINIYAKDKSKLEQIRLSIEQICENNPGSHWISYIESD
                     KQLKESFKQIEFLAWAVILFVGLIGTLNIINTTHTNINTRTNEIGVKRAIGMSNSSLY
                     KMFLWEGVYYGIFAAIFGSIAGYASAIIINMATIEKLDFTNIPITSILQATIISVLAC
                     IIATLIPLRKVKKMNIIDCIDINL"
     gene            complement(13756..15180)
                     /locus_tag="KRO40_001711"
     CDS             complement(13756..15180)
                     /locus_tag="KRO40_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092532.1"
                     /translation="MKNQSLITQFRHTFIFIIIASIVATVITYVFALYLYIHSLNKDI
                     YPPNYYERQVPRIEKYINEKNITLLSQSNEEGLKRTIRGDDMLYQVVDNNGNILYGTN
                     PKKLFKTKEELFNNFINKTVRKGGYIHTVPIKGDNGKIEGAVILFYQVKITFANIRGR
                     FVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYY
                     SDNELGKLCSAFSEMKDELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDAL
                     IGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQ
                     KVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISI
                     TVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVE
                     QLGGSVKIENSKSGGACVKFWHSI"
     gene            complement(15199..15891)
                     /locus_tag="KRO40_001712"
     CDS             complement(15199..15891)
                     /locus_tag="KRO40_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092533.1"
                     /translation="MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQE
                     PDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAKQSETDKIKGLTFGGDDYVTKPF
                     GLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIE
                     YDIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYIS
                     TVWGIGYKWNKM"
     gene            complement(15946..16722)
                     /locus_tag="KRO40_001713"
     CDS             complement(15946..16722)
                     /locus_tag="KRO40_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBH2092534.1"
                     /translation="MIKLLSSEWLRAKRTAVQWLTLCMPIIFSLCVVFYLTTKSGSTQ
                     EFAFEGFFTVWTVFIIPIGVGILAGFIVQEEELAGNFNGFLCVGISRVRLYLGKFLFL
                     LFCLTICTFIATLILCIGMSIAVPSGATIWLFLSAAGLVVIGTLPLLAIHLWVSFAWG
                     MGASIGISIGGILMAAILGLTSVGEKVWAFVPWTWPVKLGMLPGIYFIKEAGTISTEA
                     FYSKVMQTASIELIVVAIGLIIFLIGGVIWFKMWEGRKSY"
     gene            complement(16719..17489)
                     /locus_tag="KRO40_001714"
     CDS             complement(16719..17489)
                     /locus_tag="KRO40_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBH2092535.1"
                     /translation="MNALQSELLKYKRTFMGKLIVFFPVSFAAYAFIMQSTLMQNPLS
                     QTTSWAWQNLLALIFNWWSFLFLPIGFALFATLVAFQEKKAGNYRALRTHNVSPMTLW
                     INKVIAMAVYSFISTLVLIVVTIITGLILKAGPVPFGQIIGASIVCWVVSLAILPLQL
                     WLATWKGMFLSMGVGALGMIFGVLAATKPFWIAVPWSWAVRMVCPIINIHPNGTILEA
                     GDPLLNTSVIPIGIVVSLVVFIVLTALTAAWFNRRDDK"
     gene            complement(17486..18190)
                     /locus_tag="KRO40_001715"
     CDS             complement(17486..18190)
                     /locus_tag="KRO40_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH2092536.1"
                     /translation="MKDLILETKNLSKRYGEQMAVNNVSLQIERNSIYGLLGPNGAGK
                     STTLKMLVGLLRPTNGRIIFDRKPWKRESLAKIGSLIESPALYGNLTAEENLLVHTKI
                     LGIPKDKIYEVLEIVNLKNTGKKRASQFSMGMKQRLGIAIALLSDPELLILDEPTNGL
                     DPFGIQELRELIASFPKKGITVILSSHILSEVAQVVDNIGIINGGRLLFQGMPDPNEN
                     LEEFFTDVILKGGQNR"
     gene            complement(18445..18957)
                     /locus_tag="KRO40_001716"
     CDS             complement(18445..18957)
                     /locus_tag="KRO40_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092537.1"
                     /translation="MKKISQEKISTHIQEIPQEKIEQWKSLYEKYKSILKVNSKSVLE
                     IIEFLKRKYVIVEETSEEFKHVVINNIKLNKPFSQKISSDKELKPIVFTIPNEGNAKK
                     LYDTQEEIYSGCKIIVGMEFETGCVFVEGSDELNDEITSFKGLDKYDINNYYLVANYI
                     RCLKKYKLID"
     gene            19283..19540
                     /locus_tag="KRO40_001717"
     CDS             19283..19540
                     /locus_tag="KRO40_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092538.1"
                     /translation="MILNRAELFRGYSLNRFNEICNILSVNKIKYKYKVKNNAYSKKP
                     FFNEITLGNLGQKEDFSYEYLIYVHKDDYEQAESLINSKLR"
     gene            19683..20309
                     /locus_tag="KRO40_001718"
     CDS             19683..20309
                     /locus_tag="KRO40_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HBH2092539.1"
                     /translation="MKINIKSKLSEFIKQNNLFDDSRIISYLPNITIETDKIKTIMIN
                     EVVPTNTNDDFYSVDKDADYLKTTIPLFDSAGIKVSNINDILDMGIYITNAVKLPKSE
                     YTITRDTIKLHMPILEEEIKLFKNLEVVMLMGDVAKKSFNMITKKHIKKNVIPSISTY
                     KLRNNELYYDNLRVFPSYIMTGGNILIEKSKFEMASEDIKKMFEIING"
     gene            complement(20556..21335)
                     /locus_tag="KRO40_001719"
     CDS             complement(20556..21335)
                     /locus_tag="KRO40_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901940.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBH2092540.1"
                     /translation="MNSKIYYFSGTGNSLVVSNILKETLNGSKEVIPLAIHRKENNID
                     INEDILVIVFPVYFADVPDIVKSFVEKLNFNINTHIYAIATCNGVAGHSLFTIDKLLK
                     KRGKKLSAGFLINMPGNALITPPDVEEERLKNQTNRVAEIAKCINNLEIGNIEGKNNL
                     KSHIDSVVLRLVGKNMQIATTKFFAENKCNGCGTCKRVCPVENISIVDKKPKWGNECE
                     RCLACFHWCPKEAINVKKSFLTNRKKYHHPDITVKDIFLDK"
     gene            complement(21403..21864)
                     /locus_tag="KRO40_001720"
     CDS             complement(21403..21864)
                     /locus_tag="KRO40_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2092541.1"
                     /translation="MGGARDYLNGGKMKDFEKLYEATTKLVSTSLKVKDDLKKMFKQN
                     GYDITTDHYALLRFLWEQDGISQIDLCEKSCKDKSNTTRILDVMKNKGLIVRKVDVKD
                     RRKFQIFLTDLGRELEEPLNEIASIYATETFKSISDEELPLFTDILDRIGK"
     gene            complement(21840..22517)
                     /locus_tag="KRO40_001721"
     CDS             complement(21840..22517)
                     /locus_tag="KRO40_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2092542.1"
                     /translation="MIITVINGSPRKNGATSKVLTYLYKDIERLIPDVKINYFDLSEV
                     NPSYCIGCLNCYKMGKCINQNDKVEYIHDIITKSDGVIFGSPTYGSSVTGLFKVFTDR
                     AHMMLERLLYRKPCIAVTTYENARGSKAISFIKSMVLDSGGYVCGSLSIKTGFNQNPI
                     TEKVESKIQKVSKKFIYCIEEKKNPPVLSQIYNFIAINAVLKPMAFKDIEQYKGIIDR
                     WEEQGII"
     gene            22750..23136
                     /locus_tag="KRO40_001722"
     CDS             22750..23136
                     /locus_tag="KRO40_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2092543.1"
                     /translation="MKKLPHISEAEYQVMKIIWKYAPISTTEVIEKLVETSTWSPKTI
                     QTMLLRLVKKGALTYEKNSRVFVYTPLVKEEEYVARESSSFLNRFYNGTLNSMVLNFL
                     ENDKLSEDDIEELREILNKRTTKGDK"
     gene            23139..24938
                     /locus_tag="KRO40_001723"
     CDS             23139..24938
                     /locus_tag="KRO40_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaR1 family beta-lactam sensor/signal
                     transducer"
                     /protein_id="HBH2092544.1"
                     /translation="MYAPFFIRFLLSTLTLSILIVVILLAKKVFKKHISAKYQYNIGF
                     ILLIMLIIPFVPLKYINLGNVFNYLYTFNQLGSSTNRTSMIKNSPNSVINNSNALNDF
                     SVSLNQVNFDSLNILLLISWIIGILIMIAITIHCNIKIKNMKKSIQILRDDEIVFIFE
                     KCKKDIGINKDFILCKSPIINTPITFGYFKPHIILPDKSISKLSLKDIKYILLHELQH
                     FKNKDILINYIMCFLQILYWFNPLVWYAFKEMRIDREIACDISVLKKLDKDSHIEYGQ
                     TLINFVDNISRPSNLTLTSDIGGSKKQIKKRLLKIMDFHNESNTLKFKSILIFTLIAL
                     IVFGNIPKLSIMADINEKYRPTNEQTVYEDLSQYFKGFDGSFVMYDLKSKQYHIYNKE
                     KSKTRISPNSTYKIYSALLGLENGIITRNNSHIPWDGKHHSNSSWNEDQDLFSAMENS
                     VNWYFQTLDKKTGLKNIQTYLRQIGYGNYDVSGGISNFWLESSLKISPIEQVELLESF
                     YTNKFKFEDKNIETVKDSLLISKKDGVSLFGKTGTANINGKDVNGWFIGYVEKNENTY
                     FFATNIQSKDYSNGSSASKITLSILNDKKIYNP"
     gene            complement(25293..27167)
                     /locus_tag="KRO40_001724"
     CDS             complement(25293..27167)
                     /locus_tag="KRO40_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2092545.1"
                     /translation="MNKYNKIANELIKIIGEDNIISITHCATRLRVMVKDREIINDKK
                     VEKVDEVKGVFFTSGQYQIILGTGIVNKVYAEVEKMGLKTLSKKEQDELVKNNETGFK
                     KVMRTLADIFVPIIPVIAATGLFLGLKGCLFNDNVLGLLGMSSANIPLYIQTLVSVLT
                     ETAFAFLPAIIVWSAFKVFGGTPVIGLVIGLMLVSPILPNAYSVADPSNEIEAIMAFG
                     FIPIVGCQGSVLTAIVTAFIGANLEKWFRKHMPNVLDLIFTPFFVMLITMLVILLGVG
                     PIMHTIELKMVDIISLLIDLPLGIGGFIIGFTYPLAVITGLHHTYVMIETSLLANTGF
                     NALITLCAMYGFANIGTCLAFMKKSKNNQVKQTAVGAMLSQLFGISEPVLFGIQLRYN
                     LKPLIIMCASSGLGAAILSILHIQSNSYGLAVLPSYLMYIYDGYNLITYLLVSIFVVA
                     FCFIVTCLFGVPKEAINEDEDEELVFNENNENFVSPAKGKIVALENVPDETFSKKMLG
                     DGFAIDIIDGKIVSPISGKLETVVSSGHAFGIKGTNGEVLIHVGIDTVALNGDGFDVA
                     VKQGDMVKQGDVLVNVDLKRIHELGKSTLTMVLFPDGKKVNILDINKDVKIGQRICVE
                     "
     gene            complement(27172..28836)
                     /locus_tag="KRO40_001725"
     CDS             complement(27172..28836)
                     /locus_tag="KRO40_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HBH2092546.1"
                     /translation="MEKKWWQKEIVYQIYPRSFQDSNNDGIGDLQGIISRLDYLKDLG
                     ITSLWLCPIFKSPMDDNGYDISDYLDIASEFGSMEDLKELIKESKDRGIKIILDLVLN
                     HTSDEHPWFQEALKNPESPYHDYYIFKKGNDLPNNWRSVFGGSVWEKVENRDEYYFHS
                     FGKKQPDLNWENPILRSELYQMINTWSQMGVAGFRVDAITFIKKNLSFQSLESDGVDG
                     LVKCTKTVRNQPGIEKMLYELKENTFKKYDCMTVAEAAGISYDQLGDFIGEDGFFSMV
                     FDFKHADLDVASGSEWFKRISWTIPDLRKCILDSQMYVQEHGWAANFIENHDQPRATT
                     KYLLQYERNDDAVKMLGAMYFFLRGTPFIYQGQELGMTNFKRDTINDFNDLSSIDQYY
                     RSIDEGYSEEEALEFVNLRSRDNARTPFPWADKENAGFSDTTPWLKVIENYKDINAQS
                     QINNSESILEFYKKMIKLRQDSEYSDCLIYGSIEPIDIESEDVIAYRRQLDLVVIDCY
                     YNFSDKPVEIRVEEKYDIVFQNLDDINLLNKTVCLKPFHAVLLKAR"
     gene            complement(28850..29671)
                     /locus_tag="KRO40_001726"
     CDS             complement(28850..29671)
                     /locus_tag="KRO40_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH2092547.1"
                     /translation="MKLYKLLILDIDGTLRDEVYGIPESAKHAIRLCQKNHCSVVICT
                     GRSMGTIQDDVLSLGVDGYIAGGGNYIQYHGELLYNQSFNQRLIKEVVCLLKKREVAF
                     SIESQEKVFMNQKAKEIFETMNQLKGTNSCINKQHIQEKITYENNIEEYKSQDIHKIC
                     LWSNEKVFDEVKDILQDKMELAQRDISSQYYEIIQKDFHKGKAIKRLQERLGVTQKET
                     ICFGDGQNDIVMFQASDVTIAMKNSHQQLKDIATSICEDIFDNGIYKELKRRNII"
     gene            complement(29770..30534)
                     /locus_tag="KRO40_001727"
     CDS             complement(29770..30534)
                     /locus_tag="KRO40_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2092548.1"
                     /translation="MKIEGLFNKYYNSFTANDKYICECILNHKEDCIKLSIDEFADKY
                     HISTSALSRFAQKLQLPGYSELRVIIRLNETEVEYKNQSKHQLMDCYNKVIDDIEKKD
                     CSIMFERMKKANRIIVFGEGYSQERVAKEMKRIFLPTGKIIYDVYGYDMIQALNHFIK
                     TDDMIFFISLNGDASTIIDFAKEMRMKGIYMVSITKMISNPLARLCDENLYIQSISIS
                     VDKQLDYDVTTPYFILIELLYIKYKMYLESEHIPRK"
     gene            complement(30531..31280)
                     /locus_tag="KRO40_001728"
     CDS             complement(30531..31280)
                     /locus_tag="KRO40_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2092549.1"
                     /translation="MRLESLVNQNYDNLNENDKIIIKQILICQREYRNFSCEKIANEC
                     NVSRATLLRLCRKIGLDSFSDLKYLLKNNQLEFVNNDNNFHDVCENYRLLMNELQKIS
                     FQDICKIIYDAETIYIYGTGNEQKSLAQEIKRIFLSVGKCVIDLFDIGEIEFMRESFQ
                     KSDLFIIISLSGETKAGIEIAKFINNHIHTISLTRLDNNTIATLCEYNLYVETQKLDT
                     LQAISYEVVGAFYALLDLLHMNYIEYRRRKE"
     gene            complement(31784..32389)
                     /locus_tag="KRO40_001729"
     CDS             complement(31784..32389)
                     /locus_tag="KRO40_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2092550.1"
                     /translation="MKIKENVLMLDSTRGSNCFIVFDKEIILIDTGLPFMGENIIKEL
                     KTLGIKLTDIKHILLTHHDVDHISNIKLLKEKTGAKVWAHVEDIPFIIGEKDRPGFKK
                     FIGKAISRRLIKDVEPYGENMQIGNIKIIHTPGHTPGHVCMIFEDVLFAGDLVKNKNG
                     NIVPYPNPWNWDYKKMMKSISELDNLKYEWICMSHGTPCIK"
BASE COUNT        11497 a         5366 c         3909 g        11694 t
ORIGIN      
        1 tatataacta atatgttata atattttaat taaataaatt tatatttttt tgaaattact
       61 taatatttta tataaaaatg aaaaagcacc tcattctgat taaaaatctt tctgagatac
      121 tttttaaaat attaaatact acatatagct tacataagtt taaaatttaa tctattataa
      181 aattacccta attgccaaac tttttaatat aaattttcca acatcctaca aatataatca
      241 atagatatag aatcctaact tacaccaata tatatttatt taaaatagtc ctaaaatacc
      301 tgtaatagct cccactacta tcagtataaa cattattttt attggagaaa gacctttttt
      361 taaagcaaag agtactaata aagtaagtac caaaggaatt aatcctggaa atatcttatc
      421 aagtaaatct gtttgaagac taaatttaaa atcaccacta gtataactta ttggtgtaga
      481 taaattgata aacctaccta caagcccccc catgactaag gtacctagta tagaagcccc
      541 ttctataacc ttatttacta ttccaccttg aagtatactt tcaacagctt ttttcccata
      601 cttatatcca tttgtccaca ttccaaaaga aattgaagtc attattatat attgagctat
      661 tacaaataat ataggtcctg caattgatgc tcctccctca gttaaaccaa tacaaacagc
      721 caacactata ggagttataa ctccttgagt taaagtatcg ccaattcccg ctagtggacc
      781 catcaagcct gttttgatag cattcatacc atctccactt atttcatctg ctccattagc
      841 tttttcttct tccatagcta ttgttattcc atgtataaca catccacata taggttctgt
      901 gttaaaaaat gctagatgag tctccacttc ttgttttaac tcttccttat ctggatataa
      961 ttttttaagt actggcaaca ttgaatgtga aaaagctgtt gattgcaatc tttcataatt
     1021 gtaattagat tgtgcaaaga aaaaccatct taaccatgat tttattacat ctttcttgct
     1081 taacgttttc ttagatactt cattttttat atctgacata atattttccc cctcacatgt
     1141 atttaagatg tagcactatc ttttccgtac ttaattgaag taattgtaag agcaagtatt
     1201 actccaataa cagatattac tattatatct actttaaaat aaacagccat tagtattcct
     1261 aatatgaaaa agggcatagt aaacttgttt ccaatcaatt ttaaattcat agcaatccca
     1321 agtgctggca acatagcccc aattacatta aatacatgta acacattatc attcattact
     1381 tccaacatac catctatcgc atttggacca aaataaacaa ctaataatgc tggtataaaa
     1441 ctcattgcaa ataacagtat ctgtggtggt actatattta taaatgctac tctatcaaca
     1501 ttcccttttt gaacctctct atcagcccaa tgtgcaaaaa aagaatttac tgtcatcttt
     1561 ccaatccaaa gtacagttgc aacagttccc aatggtacag ctattgccat tgcagtactt
     1621 acatctagct tagatgctat agctaaagca gtacctacat atcctgcaaa agctgggtcc
     1681 cccatctgag ctccccctgc tgatataaaa cctagatata tcatatttat acctgctcct
     1741 ataattgctc cttgaacagg gtctcctaat ataattcccg ttacaaatcc agccaataga
     1801 ggtctattcc atgtaaaaaa tccaacataa gtcaaccacg gactccaaga aagataataa
     1861 aaaattgcta ttaatactgc ttgaattagt gaaatgtgca tattcttcct ccctattttc
     1921 ttttaaagat ttacaagata gtcttcttta taataatgtt cctacatcaa ttttctttgc
     1981 atctggtact atttgtataa agcatttaat atcttttgat attagctctc taaatatttc
     2041 tttttcttca tctgacacag atatattttt ataaaaactt tttctaccaa gccctgctcc
     2101 catacctcca acattcaatt cctttaaatc taccccgcta tttactaaac ctaagacagt
     2161 tttagggtat ttgaccaata ctattaaatt ttcatctcca ttatatgatt ttaagacttc
     2221 agcacctgat tctacatcat gtacttcaac cttaacagtt gatggagctg ccatttgtaa
     2281 aacttgaact ataaatgggt cctttactac taaatcatcc acgattacta tcctttttgc
     2341 tgatgtaatc ttacaccaag cagtaataac ttgcccatgt attaatctat catcaattct
     2401 tgttaatgct atattactca taattattcc tccagatttt taatttattt tacaacttta
     2461 aaacagtttt aacatctttg attcctgata tcccaacttc ctcacataaa ttcttcaagt
     2521 cttttaactt catagtatct ctgtttaaaa ataactctaa aagcataggt aaatttacac
     2581 ctgtcaaaca ttctaactca cataccttag caaatttatt tattataata gcagatgtat
     2641 taaatggagt tccgccataa aaatcaagca atactaaaac cccttcatcc ttatatttct
     2701 caattccatc ttctaacttt ctactaaact catctatgct gtcaccatgg tttaatccta
     2761 aagtttctac attttcctgt ttgcctacta ttaattcagc actttctaac attgctttag
     2821 ccatatttcc atgtgtggct ataattattc ctgccatatg aatcatacct ttcttaacct
     2881 tttttatatg gattattatt tagtactcta atctaattat ctatattaat cattatctta
     2941 ccaaagaaaa tatccctttt gtatactttt tcaaaataag ctggtacttc ttctaaattt
     3001 attctatgtg ttactaattt ttcaacattc atatcaccct tttgcatatg atacaatcca
     3061 gcactccatt cttttcctgg gaatggaaag gagtttccaa accaagttcc ctttacagtt
     3121 aattcacttc ttactatctt ttcaaattgc tctctagtca aagctacatc cccatatggt
     3181 acacctgcat acaatactgt acctcccttt ttagctagca acagtacttg accacatgtc
     3241 agtggagtac cagccgattc aataacaata tctgcaccat ctccatcagt taaccttttt
     3301 atttcttcta caatattctt ttcttttgca tttatacaaa tatctgcccc taaccctttt
     3361 gccaagtcta acttctcatc aaatacatcc acagctatta cttttgtaga accaaatatt
     3421 tttgcccatt gtattgaaaa taatcctatt ggacctgtac caagtactac aacagtatct
     3481 ccaactttag cttctgacct aaaaagacca tgtcctgcta tacatactgg ttctagcgca
     3541 gcggcagtct cataacttat ctcatctggt atttttatta aatttctctc tttcaccttt
     3601 gtatactctg caaaacaacc tccaagttct ttatttccta ttattgctac attattacat
     3661 cttgaataca atcctttttt acattcatta cattcaaaac atggcatggc tggacaaaca
     3721 gcaactctat ctcctatttt aaaactcctt acttctttac caacctgtgc cacttctcca
     3781 gaaaattcat gccctaaaat ttctccaacc atatgtggac ctgtctttga atattttgat
     3841 atatcagaac cacatattcc agctactttt actttaatta ttacatcatc tttttctaat
     3901 atttttggta catccacatc ctccactctt gtgtctctta taccatagaa tctaactgac
     3961 ttcactatta accaccccta ctttttattt gagaatatat ccctattgtt tatatgttaa
     4021 atatctaaag caactttcat gccaatatat gtaagcattg tattcatgca ttttataaaa
     4081 ttatcattaa atgtgtgtca aagtgtgtca aaagtttctt atattaaaac ttatgtgtgt
     4141 caatataaac gacactaaca ttttatatta gttctcttat tataagtttt ataaaatgta
     4201 ctttttttgt tatttttata aaattgttcg gaaattcccc ttctatttgt gatataatat
     4261 taaatataag gtatcaatat aaattttcat gcgaatatca gaactttttt gacactaatg
     4321 ccttattcaa tataataatt taactttttg gaggttgttt atgaaaaaag tgtatcaagg
     4381 aaagactaaa gatgtttttg aattagataa tggaaattac ttacttaaat ttaaagacga
     4441 tgtaactggt aaagatggag tatttgaccc aggcgaaaat agtgtaggtc taagtataga
     4501 tggaattggt agagctaatt tagagacatc tgttaagttc tttgaaattc taaacaatgc
     4561 tggaattaaa actcattatg taagtgctaa tttagaagaa gcaactatgg aagttctacc
     4621 agcaaaagtt tttggtaatg gattagaagt tatttgtcgt tatagagctg ttggtagttt
     4681 cttacgtcgt tatggttcat gtgttgaaga aggtgctaaa ctagattgtt acgtagaagc
     4741 aactttaaaa gatgatgacc gttgtgaccc tcttataaca tctgaaggtt tagaagcttt
     4801 aaacattatg actcaagctc aatttgattc aatgaaaagc atgactcaaa aaatttctaa
     4861 catagttcgt gatactatag ctgaaaaagg tcttgagctt tatgatatta aatttgaatt
     4921 tggattctac aatgatgaag taatcttaat agatgaaata gcatctggaa atatgcgtgt
     4981 ttataaagat ggtgtaatag ttgaccctat ggatttaact gctcttttat tagataaata
     5041 gtatatacat ataatttaca aatataataa acttataaat aagataagct atgaagtaaa
     5101 gactttttaa atgttgatta tttttaaaca ttttctcgcc tttaatttca tagcttattt
     5161 aaattaatat actctaatta gtagataata gctttaaccc tacaattccc accacaataa
     5221 aacctataca tgcaattctt gatatactaa taggctcatt taaaatagcc atgcctacaa
     5281 tagctgtacc gacggtacca attccagtcc atattgcata tgaagttcca agtggaagat
     5341 gttttagtgc taatgacaaa aaataaaaac ttacaatcat tccaacaaca gtaagtatac
     5401 ttggagttaa tttagaaaat ccatgtgaat tttttagttg aaaagcccaa aacacttcaa
     5461 acaaacctgc aacaaacaaa aataaccatt tcataaattc atccctcttt tcaaatatgt
     5521 ctcttatttt tccaataaaa taacctgaga aatattataa aatatctccc aggtttttgt
     5581 ccttccgtgt tcacaacaaa aactatgttg tgggttttat ctcggaccag accaatcatt
     5641 aataattgcg gaaccctata aaactctatt aattattcta ttttatctat aataatacta
     5701 tcaacatata taaaaaaagt caatatatgg gttccatata taataaaaat aacttttata
     5761 taccttttaa tattcttatt cacttctctc catacccatt tgggtcaatc taagaatatc
     5821 taatttttat ttaatatgtt ataataacat aaaaatattg aaaggagtaa tttctatgaa
     5881 tttctataaa attgcagtat gtcagatgat tactacagaa aataaaattg aaaatatcaa
     5941 tcatgctgta gatatggtaa cagaagctgc catcaatgga gctaaaattg tagttttgcc
     6001 agaaatgttt aactgtccgt atgaaaataa atattttccc aaatttgctg aagaatatcc
     6061 aggtgaaaca acaacgatat taagtaaatt agctgagaaa catggaattt atctagtttc
     6121 tggtagtatt cctgagttag aagatggaaa aatctataat acttgctatg tatttgataa
     6181 aaatggagat ctaattggaa aacatcgtaa aatgcactta tttgacattg aagttacagg
     6241 aaaagttagt tttaaagaat cagatactct tacagctgga aatgatgtca ctgtaataga
     6301 taccgaatat ggaaaagttg gtatagctat ttgctatgat attcgtttcc ctgagttatc
     6361 acgtttaatg gctcttaaag gtgctgaaat cgttatctta cctgctgcat ttaatatgac
     6421 tactggtccc gcccattggg agttatctat aagaatgcgt gctttagata atcagatatt
     6481 ctatgttggt gctgcacctg ctagaaatat gaatgcttct tatatagctt ttggaaattc
     6541 aagaatttca gacccttggg gaagaataat tgctcaagct gatgaaaaag aatgtattat
     6601 ttatgctgac attgatagag atttaattcc tgacataaga caacagttac cacttcttaa
     6661 gcacagaaga actgatttat atgaacttaa tactttgaaa taaaacagaa cataacccca
     6721 taaatcataa attaagtgtt aaaaaaattt atggggttct cattaatttg atttaaaatt
     6781 aatttcataa aaataatgct aaaattaatt taattaaata atactaataa ttactaatga
     6841 ttatgctaat tatcagcatt tactaattta atcactatta gttatttctt ttattaaata
     6901 tctttacttt tttacttatt atgtcttcta gctttacatt tggattatgg tatttctttc
     6961 tatttttagt cacatctttc tattgaatta cttgcttaaa acaccaatgc acacatgcca
     7021 gataatgttc acaattatgt agaaatcttg ctctaccttc ttcaatgttg atattatctc
     7081 tcctagttga tattatcttt cctaaaattt cttttaatta aaaaataaca ttagttgata
     7141 tatcaagtat attttaatca actgaaaaaa acaataataa ttgatatatc aactaattaa
     7201 tgtagattaa ttcattttta taatttatat actttttaat taatctacct tatttaatta
     7261 aaatccttcc tttctattta tccattttca acttaaatta taagatttca tcagctatat
     7321 ttttgcatac caataattat taaatatcaa atatatattt tattaaaatt tctaataatt
     7381 tcatccttga tttatttaat atataaaaat atactaactt taatgattaa gttttgaaat
     7441 ataactaaga atttgataat ttattgagat ttttatacta aaatatacat actatacaaa
     7501 cttaatttag aagggagcat tcttatgaac aataaaatac tcgtcgtaga tgatgaggaa
     7561 ggtataataa cactcttaaa agattacttt gaaatgaata gttatgaggt ttacactgct
     7621 caaagtggaa aagacgcatt aaaaaaaata tccaaaaatc cagatatcat tctacttgat
     7681 ataaacatgc ctgaaataga tggaattgaa gtttgtaata gaattagaga ttatgtatca
     7741 tgccctattc tatttcttac agctagaatt gaaaatactg acaagataaa tggttttcgt
     7801 gctggtgctg atgattatat tgtaaaacct tttgatttag acgaacttgg agctagagta
     7861 tctgcccatt taagacgtga acaaaggaag tcaaatcaaa ctaaaattaa attttataat
     7921 gatttaacaa tagattacga aaaaaggtta atttgtatat ataataatca gatttcactt
     7981 tcaaaaaagg aatttgatat agtagagctt ctctctatga atcctggaca agtatttgat
     8041 aaagaaaaaa tatatgatag agtctgggga tacaatagca atggaaatag tgatgttata
     8101 atggaacaca ttagaaaaat acgaatcaaa ctatcaaaac atactcttga aaattatata
     8161 gaaacagtct ggggagttgg ttataaatgg ataaaataaa taatatgtca ttaaaaaaag
     8221 ctttctttgt tcttacttta tcttcactaa ttatagcatc agtgcttact actttcgcat
     8281 acattttact taataatcta tataattcta tacaagataa gtatttaaaa acacctataa
     8341 atacaggtat tataaccata gttcaaaaca atgtgaacca atttagtgat tatgataaaa
     8401 cattacttaa tataatcaac atacttcagc ttgtacttcc acttatattt tttataggac
     8461 ttttattatt agctgatata attttttaca aggtaaaatt aaaaacaccc atagaaatac
     8521 tcaataaagg tgcaatggaa atatccaaca acaatttaga cttttgctta gagtataata
     8581 ataatgatga attaggtaat ctatgtaatg cttttgaaaa aatgaggtct gaactaaata
     8641 aaaacaacat aaagatgtgg actatgatta atgatagaaa acaacttaat gctgcttttt
     8701 ctcatgattt aagaaatccc ctaacagttc taaaaggtta ctcaaactat ttaacaaaat
     8761 acataccaac aggtaagctt agtgatgaga agattttatc aaccacacaa cttatgtctg
     8821 atcatattaa cagaattgaa tactatgtag aaaatatgag taatgctcaa cgattagaag
     8881 atttagttgt ttcaaaatct atgtcgaata taaacaagtt tatagaaaac ttagatgaaa
     8941 atatatctat cattgctaaa caagaaggaa aatcttttac acttaaaagt caaataaata
     9001 atataaatct attttttgat gaaaatatca ttcttagagt cgtcgaaaat ataatatcga
     9061 atgcttttag atatgctaga aataatgtat ccatacttat atatcttgaa caagaactcc
     9121 ttacctttgt aattgaagat gatggtatag gatttagtaa ggaatctcta aaattagctt
     9181 taagaccttt ctatagagat aagactttaa atgacagcaa tgcacacttt ggtatgggtc
     9241 tttatatctc aaaaatatta tgcgaaaaac atggtggctc tatttctatt gaaaataatt
     9301 ctactaacag tgctaaaatt actgctaaat tctcaacaag aaattaaaat gattttgtaa
     9361 gctttcactg ttcttatata aaatttgtta gtttagaatt tataaaatgt atttcaattt
     9421 acaaccaata tatatactat tttgtagaag ttgtaagagt tgcttcaatt ataatatttt
     9481 ggcaaaaggc atttgaaaca ataatagaaa tatatattta aatatgtaga atagtatgaa
     9541 attagaattt tggaggtgat tatattaaaa gttttgctaa taatattaca ttctctcgta
     9601 ttgtgtttgc attgctaatg cttagttcta cattctgttc actgcctttc tggatatgtt
     9661 atttttggtg tggaattagt gatatatttg atggtcttat tgcccgaaag ttgagacaac
     9721 aaagtggaat aggtgcaaag ttagatagta ttgctgattt cattttttcg gttacaattt
     9781 tggttactgt cggaaaaaat attgctcttc ccatgtatct atggtggtgt attgttgcaa
     9841 tagcattgtt acggttgatt agttacagta ttggtttttt taagtatcgc acattttcat
     9901 cgcttcatac tttgatgaat aaaatcactg gaatttctat ctttgcgttt ccattactct
     9961 atatttgctt tggtcttgat gttgcaggaa ttatgatatg tatcgtggct tttctttctt
    10021 cttttgaaga aatagcaatt atgataaaat caaaagaatt aaatcgtgat ataaaaagta
    10081 tatttatgtg aaaacttaga atttgtgaca aaaataattt atataataat gaggaagtaa
    10141 aacataaaaa attatccaca agtttatgtg taaaatagtt ttaaagcaat agagttgtat
    10201 tgtaaagcct ttagtgcata aattacattt taaattaaaa atgatactga aactgcttat
    10261 cagcactgcg aattatccgc aaatagtgaa gactttttag atttaagcta aaagttggga
    10321 aaaaattgag ttttaaaact tacactcttc ttatatagaa aaggagagtg ttttttatga
    10381 ttataaaagc aaaacaatta tcaaaaatat atggttctaa taacaataaa gttatcgcac
    10441 ttaataatgt aaatttagaa ataaactcag gtgaatttgt ttctgtaatt ggaccttctg
    10501 gaagtggaaa aagcacactt ttacatattt taagtggatt agataatcct acctctggac
    10561 aagtgttact tgatgataaa gatatatata aacacactga aaaagaacta tctgcactta
    10621 gaagaaaatc ctttggattc gtctttcaac aatttaatct tttacctgtt ctgacagcat
    10681 ctgaaaatat ttcaatgcct gtacttctag ataaaaaaca acctgataaa gaatatttaa
    10741 atgaaatctc atcattactt ggaattgcag atagactcaa tcatcttccc catgaacttt
    10801 caggtggtca acaacaaaga gttgcaattg ctagagcact tattgcaaaa ccagatataa
    10861 tatttgctga tgagcctaca ggaaacttgg acagtaaaag tggcagtgaa gttatgaatc
    10921 ttcttataaa aacttcaaaa cagtttggaa agactttagt ggtaattact catgatgata
    10981 gaattgcaaa acttgctgat agaaaaattt caattattga tggtgttctt atggaggtga
    11041 aatagaaatg aagaattacc tttcactttc aataaaagaa ttaaaaagcc agaaacttat
    11101 gactacattc atcattatag caatagtact atcaactatt atgacaactg tggttggaca
    11161 gtcaattggt atcctacaaa atttaagaat tgaacaagcc cgttctttta acggtgatag
    11221 acatgtatcc tttcaccaac ttactaaaaa tcaagttgat gacataaaga aagatgatag
    11281 agtttatcaa gctggtactt caataactct tggcagtagt aaaataaagg attctggtat
    11341 ctctgtactt gtaaaagagt atgataaaac aggactttcc aactacccca aattaatgaa
    11401 attaaaatct ggaaatttgc ctaaagataa aaacgaaata gccttagatg aaaacacact
    11461 aaagcttatg ggtataaaac caagactagg agtgactata cctatgaatt tagatatttc
    11521 acttttaaat gataccatac caccatataa ttacacagct aactttaaat tgagtggcat
    11581 tttagaggat gattatacag gatatgtaag tggtatagta aatggtattg taggtaaagg
    11641 tacatcagaa aatctattac ctaagagata tattttatcc tctttggatt ttaaaataaa
    11701 acagcaagaa aagtttcaag aaatagtaaa tcaattagct aaaaaaataa atctttctca
    11761 caattcaatt caatataatt ggatttactt aaatgctctt aagatacagt ttgaaaaaga
    11821 tgaaaatagt tctaatagtg atggtatatc tatgattata ttggtatctt tatttgttgc
    11881 cttattggtt ttactggcct ctggacttgt aatctataat attttaaaaa tctctgttac
    11941 aaagaaaatt aaagagtatg gatgtttaag agcaatagga gctgaaccaa accagatata
    12001 taagatagtt attttacaaa tcttaatttt atgtactgtt gccataccta ttggagctgt
    12061 aattggaatt atatcttcta aaggcataac tggaatggtc actaatatct taaatccaga
    12121 tatacttcta gcaaatgata ataaagaaat tactgagctt atacataaaa atacaacagc
    12181 atatatgttc ccattagtat taagcactaa tgtatctttg attttttcat ttatttcagc
    12241 attaccatca gcaatatatg cttcacatgt ctctcccaaa attgctatgg ttggtagtac
    12301 taccaaaatc aaaagaaaaa ttaaaagaga aaaaacaata aaaaactttg aaagacatct
    12361 agcatggcta aacttaaaaa gaaataaagg aagaactata ataactatac tatcattatt
    12421 tatgagtata acagtattcg ttgcactgag tgagttctct aatgtattag atgtatctag
    12481 gtcagtaagt aatttaaaag aaggagattt ttccttaaca aatgaaatat ctggttttga
    12541 taaatcaaca ctagataaaa taactaaaat gaaaaacgtc aatcgcactt cctttataaa
    12601 gtactctgaa tacaaacagg gggaaataga tacagatata aattttgaaa atagtggtga
    12661 gatgttaaaa atcattggaa ttgatgagca aactttaaaa gacttaatgc cttctattac
    12721 agattctata ctagaagact ttaaaaatgg ttctatctgt tttataaaaa atccgattgc
    12781 tatttctaca ccaggtgtaa aaactagaca tacaaattta aaacctaaag atagtatcac
    12841 aatcaacaaa aaacaactag atatatatag tacagtagat aaaatgttct ttttacaagg
    12901 taatggctgg ataaatggtg ttgatgttat tgtatatgat tctgtttata acaccttgac
    12961 aaataaaaac aagttcaacc agataaatat ttatgctaaa gataaatcaa aattagaaca
    13021 aataagattg tctattgaac agatttgtga aaataatcct ggctctcatt ggatatcata
    13081 tattgaatca gataaacaac ttaaagagag ttttaaacaa atagaatttc tagcatgggc
    13141 agttatatta tttgtgggat tgattggtac tttaaacatc attaacacaa ctcatacaaa
    13201 tataaatact aggactaatg agattggagt taaaagagct attggtatga gtaatagtag
    13261 cttatataaa atgtttttat gggaaggtgt ttattatgga atttttgctg ctatatttgg
    13321 ttcaattgct gggtatgcca gtgctattat tataaacatg gcaactatag aaaagcttga
    13381 tttcactaat ataccaatta cttcaatttt acaagctact attatttctg tacttgcatg
    13441 tattatagct actcttattc cgttaagaaa agttaaaaag atgaatataa ttgactgtat
    13501 agatatcaat ttataactat tttacagata ataatataaa ttaaattatc aatgactgtc
    13561 tctattttct ttcaaatcta actaataaat ctttttaact ataatataag ctttaaaaaa
    13621 ggcctatctc aaaatagaga taagcctttt ttcattgtcg aaataatgaa aatatattta
    13681 acttcacaaa aaaagagtgc ctcacgaatt aaaaatttcg ctttgagaca ctccccttta
    13741 atttaaaata tatagttaaa tgctatgcca aaatttcaca catgctccac ctgattttga
    13801 attttctatt ttaacagaac ctccaagctg ttccactaat tgtttgacaa tgtaaagccc
    13861 aagaccagaa tgtccacctt ttgtctgcct agcttcatct cctcgataaa atttatcaag
    13921 agcctttttt aaatctttag agctaaaccc tctaccagaa tcacaaatct cataagaaat
    13981 acaatttttt tcatccttta cagtaatact aatattacca cctgatggag tgtattgcag
    14041 actgttggat atgatattat caaaaattcg tgtcaaccta tccacgtcga tttgaattgg
    14101 ggattgtata ttcccctgca ttttcaatat aagttcaact tccttttgat gagcctgtaa
    14161 ttcatagtct tgcacctttt gcctcaaaaa ttcaggtaaa tttataggaa caagatttaa
    14221 ttgtatattt gacttttcta agtcagacgt atattgcatc ttttggacaa gagcagcact
    14281 tttttctgta ttttctctta tcactgtaag atacctatga agtttttcat tgtcatctgt
    14341 attattacca ataagtgcat ctgtatatcc caaaataata gaaagaggag attttaaatc
    14401 atgtgctaga gcttccacca tttcaacacg ttcctgctcc atcttccact gtgcagataa
    14461 agagcctttt aattcgtctt tcatttcaga aaatgcacta caaagtttac cgagttcatt
    14521 atctgaataa tagtcgattt caaaatcaag gtccttttct tttatcttct tggacgcatc
    14581 aatcaataga tgtaatggtt gattgatatt ctttacaaag cgcttagaaa gccatctagt
    14641 aaaacccaca atatatagaa atggagaaaa cagagccatt ataataactg caaatacaaa
    14701 tctccctcta atatttgcaa aggtgatttt cacttggtag aatagaataa cagctccctc
    14761 aatctttcca ttatcccctt tgattggaac agtatggata taaccacctt tacgaacagt
    14821 tttattgata aaattattaa ataattcttc ttttgtttta aatagttttt tggggttagt
    14881 accatataaa atattgccat tattatccac aacttgatat agcatatcat ccccacgaat
    14941 cgttcttttt aaaccttctt cattcgattg tgataacaaa gttatgtttt tttcattgat
    15001 gtatttttca attctaggaa cttgtcgctc ataatagttt ggtggataga tatccttatt
    15061 taaggaatga atatacaaat agagagcaaa tacataagta atcactgtgg caactatact
    15121 ggctattata ataaaaataa aagtatgtct aaattgggta ataagggatt gatttttcat
    15181 ttaataacct ctctctcttt acattttatt ccacttatac ccaatacccc aaactgtgga
    15241 aatatattct ttttctggtg tcacagcaga aaacttagct cgtatttttt ttactcgttc
    15301 aacaacagtt gaggaatcac cttcagaatc acacccccat actttttcat agatttgttc
    15361 tcttgagaaa acttgtcctg catggagtgc tagtaattca acaatatcat actctatttt
    15421 tgttaaatca atattcttac catcaatttt aattgcacgt tccttcatat ataagcataa
    15481 cttcccaaaa tacaaagtag atctcttgtt ctcttcattg atatactgtg aacgcttttc
    15541 cctacgcaga ttagcttcaa tccttgccat aagttcacgc agtccaaatg gctttgttac
    15601 ataatcatcc cctccaaagg tcaacccttt gattttgtcg gtttctgatt gctttgcact
    15661 taaaaatata attgggcata aaacatcatc tctaattgcc tgacatacct caaatccatt
    15721 cattttaggc atcataatat ccagtataat aaggtcaggc tcctgttttg ataactctat
    15781 acctgcctga ccatcataag ctatcaacac ttcatgtcct tttgccttca attcatcctc
    15841 aagtagcatt actaggtcca tttcatcatc aataatcaat attttactca atataacacc
    15901 acctttctct tatgggaagg tcagtattaa aacaatattc gtctactaat aacttttcct
    15961 tccctcccac attttaaacc aaataacgcc tcctatcaag aatataatca aacctattgc
    16021 tactactata agctctatac tagctgtttg catcacttta gagtaaaatg cctcagttga
    16081 aatagttcca gcttctttaa taaaataaat tcctggaagc atacctagtt ttactggcca
    16141 tgtccatgga acaaatgccc atactttttc accaacgcta gttaatccaa gtattgctgc
    16201 catcaaaatt ccaccgatac taataccaat agatgcaccc ataccccatg caaaactcac
    16261 ccaaagatga atagctaata gtggaagtgt cccaatcacc acaagtcctg ctgctgacag
    16321 gaataaccat attgttgctc cagatggcac tgcaatactc attcctatgc aaagtatcaa
    16381 cgtagcaata aatgtgcata tagttaggca aaacagaaga aaaagaaatt ttcccagata
    16441 taatctaaca cgagaaatac ctacacataa aaaaccatta aaatttccag caagctcttc
    16501 ctcctgcact ataaatcctg ctaaaatacc tactccaata ggaatgatga atacagtcca
    16561 tactgtaaaa aatccttcaa aagcaaattc ttgtgtactt ccagatttag ttgtgagata
    16621 aaaaaccaca cataatgaaa aaataatagg catacaaaga gtaagccact ggacagctgt
    16681 cctctttgct cgaagccatt ctgatgataa tagctttatc atttgtcatc cctcctattg
    16741 aaccaagctg cagtaagtgc tgttaatact ataaacacaa ccaaagaaac aacaatccca
    16801 ataggaatca ctgaagtatt caaaagtggg tctccagctt ctaatatagt accgttagga
    16861 tgtatgttga tgattgggca taccattcta actgcccaac tccaaggtac tgcaatccaa
    16921 aatggttttg tcgcagcaag gacaccaaat atcataccta aagctccaac tcccatactt
    16981 aggaacatac ctttccatgt agctagccat agctgaagtg gaagtatagc aagagaaaca
    17041 acccagcata caatacttgc ccctataatc tgtccaaaag gaactggacc agctttcaat
    17101 attaaaccag ttataattgt tacgactatt aaaactagcg ttgaaataaa actgtagact
    17161 gccatagcta taactttatt aatccaaagt gtcataggag acacattgtg tgtacgtaaa
    17221 gcacgataat ttccagcttt tttttcctgg aaagctacca aagtagcaaa caatgcaaat
    17281 ccaataggca gaaataaaaa tgaccaccag ttaaaaatta atgctaaaag attttgccac
    17341 gcccaagaag ttgtttgaga taatggattt tgcatgagtg ttgattgcat tataaatgca
    17401 tatgctgcaa aagacactgg gaaaaaaaca ataagtttac ccataaatgt tcttttatac
    17461 tttaaaagtt ctgattgtaa agcattcatc tgttttgtcc tcctttaaga ataacatctg
    17521 taaaaaattc ttctagattt tcattagggt caggcattcc ttgaaataat agtcgtcctc
    17581 catttataat tcctatatta tctacaactt gagcaacctc tgatagaata tggctagaaa
    17641 gaattacagt tatacctttt tttggaaaag aagcaatcaa ttcacgcaat tcttgaatgc
    17701 caaaggggtc aagaccattg gttggttcat ctagtattaa caactctggg tcactcaaaa
    17761 gtgcaatagc tattcctaac ctttgtttca tacccataga aaattgtgaa gctctctttt
    17821 tacctgtatt tttcaaattt actatttcca acacttcata aattttatct ttaggtattc
    17881 ccaatatttt tgtatgtact aacaaatttt cctctgctgt aaggtttcca tacaatgcag
    17941 gggattctat taaagaacct atttttgcaa gagattctcg tttccaaggc tttctatcaa
    18001 aaataatacg accatttgtt ggacgaagaa gaccaacaag cattttaagt gttgtggact
    18061 ttcctgctcc atttggtcct aaaagtccat atatactatt tcgttcaatt tgtagagaaa
    18121 cattgttaac tgccatttgt tctccatatc tttttgataa gttttttgtt tcaagaatta
    18181 aatctttcat attaatttct cccttcttgt aataccttaa atctgttact aagagaatac
    18241 taacatgaaa aaataacaat tctataacac ctactaattt taataaaatt taaaataaaa
    18301 aatagagtta ccaattttat tttggcaact ctatttaagt ttatgtttta cagttatatt
    18361 agatttaaac ttagtttcat tatcacacta acttcaaatt tactctataa tctttaaatc
    18421 aaacactaat ttattaatca aacactaatc tattaattta tatttcttta gacatctaat
    18481 atagtttgct actaaataat aattatttat atcatattta tctaatcctt taaaagaagt
    18541 tatttcatca ttaagctcat cactaccttc tacaaaaaca caacctgttt caaattccat
    18601 acctacaata atcttacagc cactataaat ttcctcttga gtatcgtaca atttttttgc
    18661 atttccttca tttggaattg taaatacaat aggttttaat tctttatcac tggaaatctt
    18721 ttgtgaaaaa ggcttgttta acttaatatt attgataact acatgtttaa attcctctga
    18781 agtttcttct actattacat attttcgctt taaaaactct attatttcta aaacagactt
    18841 agaatttact tttaaaatac ttttatattt ttcatataaa gatttccact gttcaatttt
    18901 ttcctgtggt atttcttgga tatgtgtact tattttttct tgagatattt ttttcaatta
    18961 aactctcctt tcaatactta aatatcctta tgaatctcac atgactaaag ttacaaggtt
    19021 tctacttaat agaattttgc atacttaaat atgtcttatt aattctctac aggatatctc
    19081 tgtaattcct acgattctta cataagttac ttattttaaa ttgttattag ttagattcta
    19141 aaaattattt attttatcac taatataata ctcttaaaaa ctttacaaat caatttaaat
    19201 ttgctacctt ttatttataa caacttatag tacatttctc ctatgctttt caatatatta
    19261 cttttaaaag gaggttttca ttatgatttt aaatagagct gagcttttcc gaggatattc
    19321 tttaaataga tttaacgaga tatgcaatat attatcagta aataaaatta aatataagta
    19381 taaagtgaaa aataatgctt actctaaaaa accttttttt aatgaaataa cacttggcaa
    19441 tttaggtcaa aaggaagatt tctcttatga gtacttaatt tatgttcata aagacgatta
    19501 tgaacaggca gagtctctaa taaattctaa gttgcgatag attatttata aaacatgaca
    19561 ttctgttgtc atgttttata tgttattata ctttcaaata tgctactata ttttcaaaat
    19621 tgtgtgcttt aaaactagct ttttatagta atttaaagct taaaactaag gagactcgtt
    19681 atatgaaaat aaatataaaa tcaaagttaa gtgaatttat taaacagaac aatctttttg
    19741 atgacagcag aataatatcc taccttccta atataacaat agaaacagac aaaataaaaa
    19801 ctataatgat taatgaggtt gtcccaacta acaccaatga cgatttttat agtgtagata
    19861 aagatgctga ttatttaaaa actactattc ctttatttga cagtgcagga ataaaagtat
    19921 ctaacataaa tgatatccta gatatgggta tctatataac taatgcagta aaacttccta
    19981 aatcagaata tacaataact cgtgatacaa ttaaattaca tatgcctatt ttagaagaag
    20041 aaattaaatt atttaaaaat ctagaggtag taatgttaat gggagatgtt gcaaaaaaat
    20101 cttttaatat gattactaaa aagcatataa aaaagaatgt catcccttcc atttcaacat
    20161 ataaacttcg taataatgaa ctttattatg ataatttaag agtatttcca tcatatatta
    20221 tgactggtgg aaacatactg attgaaaaat caaaatttga aatggcatca gaagatataa
    20281 aaaaaatgtt cgagattata aacggttgat attacaaaat aataaaaact aatataaaat
    20341 aaaaagtgcc tcaaaaactt ctatttatga ggcactttta ttttatatta gtgtaactat
    20401 atactattaa cataatttat tatttatatt gttcttttta atctctattc catttagtct
    20461 aggtaacatt actctttaca agattacttt atatttcttt tatatctcta acgtttttat
    20521 ttaataaaac aattattaat acaagtcaaa tatatctatt tatctaaaaa tatatctttt
    20581 acagtaatat ctggatggtg atacttcttc ctattcgtta aaaaagattt ttttacatta
    20641 atagcctctt ttggacacca gtgaaaacaa gctaggcatc tttcacactc attaccccac
    20701 tttggctttt tatcaactat acttatattc tctacaggac aaaccctttt acatgtccca
    20761 catccattac atttattttc tgcaaaaaat ttagtagttg caatttgcat attcttacct
    20821 actaaacgaa gtacaacact atctatatgt gactttaaat tgttttttcc ttctatattt
    20881 ccaatctcca agttattgat acattttgca atctcagcta ccctattagt ctgatttttc
    20941 aatctttctt cttcaacatc tggaggtgtt atcaaagcat ttccaggcat attgattaaa
    21001 aaaccagcag ataatttttt cccccttttt ttaagtaact tatctatagt aaataaacta
    21061 tgtccagcta ccccattaca agtggcaatg gcatatatat gagtattaat attaaaattt
    21121 aatttctcta caaaagactt tactatatca ggaacatcag caaaataaac aggaaaaaca
    21181 attaccaata tatcttcatt tatgtctata ttattttctt ttctatgtat agctaagggt
    21241 ataacttctt tacttccatt taacgtttct tttaaaatat ttgaaactac tagcgaattt
    21301 cctgttccag aaaaataata aatcttacta ttcattctta tccctctttc tatatttcta
    21361 catcatcaat agttaaaaag tctcttaaaa taggatttat atttactttc caattctatc
    21421 caaaatatca gtaaacaaag gcaattcttc atcagagata gatttaaatg tctctgttgc
    21481 atatatactt gcaatttcat ttaatggttc ttctaattct ctacctaaat ctgttaggaa
    21541 tatttgaaac ttacgtctat ctttaacatc tactttacgg acaattaatc ccttattttt
    21601 cataacatct aagattcttg tcgtattaga tttatcctta catgattttt cacataaatc
    21661 tatctgagaa attccatctt gctcccatag aaaccttaat aacgcataat ggtcagttgt
    21721 tatatcatat ccattttgtt taaacatctt ttttaaatca tcttttactt ttaacgaagt
    21781 acttactaac ttagttgtag cttcatatag tttctcaaaa tctttcattt tacctccatt
    21841 taaataatcc cttgctcctc ccatctatca attattccct tatattgctc aatatcttta
    21901 aaagccattg gctttaaaac agcatttata gcaataaaat tatagatttg agaaagaaca
    21961 ggtggatttt tcttttcctc tatgcaataa ataaattttt tagatacctt ttgtatcttt
    22021 gattctactt tttcagttat aggattttga ttaaatccag tttttataga taaactacca
    22081 caaacataac ctcccgaatc taagaccatg gattttataa aagaaattgc ttttgaacca
    22141 cgtgcatttt catatgtagt aactgctata catggcttac gatacaataa tctttcaagc
    22201 atcatatgtg ctctatctgt aaacaccttg aaaagtccag ttacactact tccataagtt
    22261 gggctaccaa atataacacc atcactctta gtaattatat catgaatata ctctacttta
    22321 tcattttgat tgatacactt gcccatttta taacaattta aacaaccaat acaatatgat
    22381 ggatttacct cacttaaatc aaaataatta atttttacat ctggtattaa tctttctata
    22441 tctttataca agtaagttaa aacttttgat gtagctccat tttttctagg gcttccattt
    22501 ataactgtaa ttatcatttc tatatctcct ttttagttgt tatatcaaca ataagtatat
    22561 caactatatt tttagctgtc aatataaacc atttatttaa agccatactt acacagctta
    22621 aataaaagtt ttatttaact acatgtgctt atttaatcaa ctataaatga attattttta
    22681 ataattgaca aactaaatta atgataatat actttatgta ttacaaatgt aagtagaagg
    22741 aggtatagta tgaaaaagtt accacatatt tcagaagcag aatatcaagt tatgaaaatt
    22801 atttggaaat atgctcctat cagcactact gaagtaattg aaaagttggt agaaacaagt
    22861 acatggagtc ctaaaacaat tcaaacaatg ttattgagat tagttaaaaa aggagcttta
    22921 acatatgaaa aaaatagcag agtattcgtt tatactccac ttgttaaaga agaagaatac
    22981 gtagctagag aaagtagttc ttttttaaat cgtttttata atggtactct taattctatg
    23041 gtactaaact ttttagaaaa tgataaacta tctgaagatg atattgagga actgagagaa
    23101 atcttaaata aaaggacgac taagggggat aaataaatat gtatgcccca ttctttatac
    23161 gatttttact cagtacatta accttatcaa tattaattgt tgtaatttta cttgccaaaa
    23221 aagtatttaa aaaacatatt tctgcaaagt accaatacaa tattggattt atattgctta
    23281 taatgttaat aattccattt gtccctctta aatatattaa tcttggaaat gtatttaact
    23341 atttatatac ttttaatcaa cttggaagca gtactaatag gacttctatg ataaaaaata
    23401 gtccaaattc tgtaattaat aactcaaatg cattaaacga tttttcagta tccctaaacc
    23461 aagttaattt tgatagttta aatattttat tactaatatc atggataatt ggaattttaa
    23521 tcatgatagc tattactatt cattgcaaca ttaaaataaa aaatatgaaa aaatcaatac
    23581 aaattttaag agatgatgag atagtattta tatttgaaaa gtgtaaaaaa gatattggta
    23641 taaataagga ttttatacta tgcaaatcac ctattataaa tacacctatt acatttggat
    23701 actttaaacc acacattata ttaccagata agtctatatc taaattatct ttaaaagata
    23761 taaaatatat cttacttcat gaattacaac actttaaaaa taaagatata ctgataaatt
    23821 atataatgtg cttccttcaa atattatatt ggtttaatcc tcttgtatgg tatgcattta
    23881 aagaaatgcg tatagaccgt gaaattgcat gtgatatttc agttttaaaa aagcttgata
    23941 aagatagtca tatagaatat ggacaaactc taataaactt tgtggataat atttcaagac
    24001 catcaaatct tacacttaca tcagatattg gtgggtcaaa aaaacaaata aaaaagcgac
    24061 tattgaagat aatggatttt cataatgaat caaatacgtt aaaattcaaa agcattttaa
    24121 tttttacatt gatagcttta attgtatttg gaaatattcc caaactatct attatggcag
    24181 atatcaacga aaaatataga cctacaaatg aacaaactgt gtacgaggac ttaagtcagt
    24241 attttaaagg ttttgatgga agttttgtta tgtatgattt aaaatccaag caatatcata
    24301 tttacaataa agaaaaaagt aaaacaagaa tttctccaaa ttctacttat aagatttata
    24361 gtgccttatt gggattggaa aatgggataa taacaagaaa taattcacat atcccttggg
    24421 atggaaagca tcattctaat agttcttgga atgaagacca agacttattt tctgctatgg
    24481 aaaactccgt aaactggtac tttcagactc tagataaaaa aacagggcta aaaaacatac
    24541 aaacttatct taggcaaatt ggatatggca attatgatgt ttcaggtggt atctcaaact
    24601 tttggctaga atcttcatta aaaatatcac ctattgaaca ggtagaatta cttgaaagtt
    24661 tttatacaaa taagtttaaa tttgaagata aaaatataga aacagtaaaa gattcattgt
    24721 taatatcaaa aaaggatggg gtatcacttt ttggtaaaac aggcactgcc aatataaatg
    24781 gaaaagatgt aaatggttgg tttataggtt atgtggaaaa aaatgaaaat acttatttct
    24841 ttgctacaaa tattcaaagc aaagattatt ctaatggtag ttcagcatct aagataacat
    24901 tatccatatt aaatgacaaa aaaatctata atccttaata tatttactgt acattctaaa
    24961 aaattcacat aattttcata ttaattatca attaaattca tatacaaggc ttattatata
    25021 aacatagaag atagtaaaac tagcttaaaa acataatata ataccctata caaatagtgg
    25081 caactctccc tcacatcctc aattgttgcc actatttaat tttttgtatg aagttaaata
    25141 tattttcatc atttcaacaa tttgggtgca atacaatctc tattttgaaa caacctcttt
    25201 aattgtttta gagtttatga attatttctc atactttaaa aagattgaat tactcttgat
    25261 aatcttcttt tgtagtcatt acatatcacc tactactcaa cacatattct ttgacctatt
    25321 tttacatcct tgtttatatc caaaatattt accttcttac catctggaaa caataccatt
    25381 gtcaaagtag actttcctaa ttcgtgtatt ctctttaaat caacattaac aagaacatct
    25441 ccctgtttaa ccatatctcc ttgtttaaca gcaacatcaa agccatctcc atttaatgca
    25501 actgtatcaa ttccaacatg aattaatact tctccattag ttcctttaat cccaaatgca
    25561 tgtccacttg aaaccactgt ttctaattta cctgaaatag gagaaacaat ttttccatct
    25621 ataatatcaa tagcaaaacc atcacctaac atttttttag aaaatgtttc atctggtaca
    25681 ttttctaatg caacaatttt ccccttagct ggagacacaa agttttcatt attttcatta
    25741 aacactaatt cttcgtcttc atcttcattt atagcttctt taggcactcc aaataaacat
    25801 gttacaataa agcagaatgc aaccacaaat attgatacta ataagtatgt gattaaatta
    25861 tatccatcat agatatacat taaataagaa ggtaaaactg ctaatccata tgaattagat
    25921 tgaatatgta aaattgataa tattgctgct cctaaacctg aagatgcaca cataataatc
    25981 aaaggcttta aattatatcg aagctgaatc ccaaataaaa caggctcact tataccaaaa
    26041 agttgagata gcattgctcc aaccgcagtt tgtttaactt gattattttt agattttttc
    26101 ataaatgcta gacatgttcc aatattcgca aatccataca ttgcacaaag agtaataagg
    26161 gcattaaatc ctgtatttgc taatagtgat gtttcaatca ttacataagt atgatgtaag
    26221 ccagtaataa cagctaatgg atatgtaaat ccaataataa atcctccaat tcctaaaggc
    26281 aaatcaatca ataagctgat gatatcaacc atttttaatt ctattgtatg cattataggg
    26341 cctacaccta acaaaataac taacattgtt attagcataa caaaaaatgg tgtgaaaata
    26401 aggtctaata cattaggcat atgtttacgg aaccattttt caagattagc tccaataaat
    26461 gctgtaacaa tagctgttaa aacacttcct tgacaaccta caataggaat aaatccaaat
    26521 gccataattg cttcaatttc atttgatggg tcagcaacag aatatgcatt aggaagtatt
    26581 ggggaaacta acataagtcc aataacaagt ccaataacag gtgttcctcc aaatacttta
    26641 aatgctgacc atacaataat tgctggtaaa aaagcaaatg ctgtttctgt aagaactgaa
    26701 acaagtgtct gaatatacaa tggaatattt gcagaagaca ttcctaataa tccaagtaca
    26761 ttatcattaa acaaacaacc ctttaatccc aagaataatc ctgttgctgc aataactgga
    26821 ataataggaa caaatatatc tgctagagtt ctcataactt tcttaaatcc agtttcatta
    26881 tttttaacta attcatcttg ttcttttttt gataaagttt ttaatcccat tttttcaact
    26941 tctgcataaa ctttattaac tattcctgtt cctaaaataa tttgatactg tccagaagta
    27001 aagaaaaccc ctttaacctc atcaactttt tcaactttct tatcattaat aatttctcta
    27061 tctttaacca tcactcttaa tcttgtggca caatgtgtaa tagaaataat attatcttca
    27121 ccaataattt taataagctc atttgctatt ttattatatt tattcatttt tctacctcgc
    27181 tttcaataat actgcatgaa atggtttcaa acacactgtt ttatttaata gatttatatc
    27241 atctaaattt tggaatacaa tatcatattt ttcttctact cttatttcta caggtttatc
    27301 agaaaaatta taataacaat caataactac caaatctaat tgccttctat acgcaataac
    27361 atcttcactt tctatatcaa taggttctat tgaaccataa atcaaacaat cagaatactc
    27421 actatcttgt ctcaacttta tcatcttttt ataaaattct aaaatactct ctgaattgtt
    27481 aatctgactc tgtgcattaa tatctttata attttcaata acctttaacc atggtgttgt
    27541 atctgaaaaa cctgcatttt ctttatctgc ccatggaaat ggcgttcttg cattatctcg
    27601 gcttcttaaa ttcacaaatt ctaacgcttc ttcttctgag taaccttcat ctattgaacg
    27661 atagtattgg tcaatgctag ataaatcatt aaaatcattt atggtatctc ttttaaaatt
    27721 tgtcattcct aattcctgcc cctgataaat aaatggggtt cctcttaaaa agaaatacat
    27781 tgctcccaac atttttactg catcatcatt cctttcgtat tgcaaaagat actttgttgt
    27841 agctcttggt tggtcatgat tttcaataaa attagctgcc catccatgtt cctgaacata
    27901 catttgacta tctaaaatgc attttcttaa atctggaatt gtccatgaaa ttcttttaaa
    27961 ccactcacta ccagaagcaa catctaagtc agcatgttta aagtcaaaga ccattgaaaa
    28021 gaaaccatct tctccaataa aatcacctag ctggtcatag ctaatacctg ctgcttcagc
    28081 aacagtcata caatcatatt ttttaaacgt attttctttt aattcataaa gcattttttc
    28141 tattccaggc tgatttctaa ctgtttttgt acatttaaca agaccatcaa caccatcact
    28201 ttctaaactt tgaaaactta aattcttttt gataaatgta atagcatcaa ctctaaatcc
    28261 tgccactccc atttgagacc aggtattaat catttggtaa agttcacttc ttaatattgg
    28321 attttcccaa ttaaggtcag gttgtttttt accaaaagaa tgaaaataat attcgtctct
    28381 attctctacc ttttcccaaa cacttccacc aaaaacagac ctccagttat ttggtaaatc
    28441 gtttcctttt ttaaaaatat aataatcatg ataaggactt tctggatttt ttaatgcttc
    28501 ttgaaaccaa ggatgttcat cacttgtatg attaagaact aaatctaata taattttgat
    28561 tcctctatct ttactttctt taattaactc ttttaaatct tccatacttc caaattcact
    28621 tgcaatatcc aaataatcac taatatcata cccattatcg tccataggtg atttaaaaat
    28681 tggacataac cacaatgatg taatacctaa atcttttaaa taatctaaac gagaaataat
    28741 tccctgtaaa tctccaattc catcattatt actatcttga aagcttcttg gataaatttg
    28801 ataaacgatt tctttttgcc accatttctt ttccataaat tactcctttt tatatgatat
    28861 ttcttctttt taattcttta taaattccat tatcgaatat gtcctcacat atagatgtcg
    28921 ctatatcttt aagttgttga tgactatttt tcattgcaat tgtaacgtct gatgcttgaa
    28981 acatgacaat gtcattttga ccatcaccaa aacatatggt ttctttttga gttactccta
    29041 atctttcttg taatctctta attgctttgc ccttatgaaa atctttttga ataatttcat
    29101 aatactgact agaaatatct ctctgtgcta attccatttt atcttgtagt atatctttca
    29161 cttcgtcaaa taccttttca tttgaccata aacaaatttt atgtatatct tgtgacttat
    29221 actcttcaat gttattttca tatgttattt tttcttggat atgttgttta tttatacaag
    29281 aattagttcc tttcaactga ttcattgttt caaatatttc tttggctttt tgattcatga
    29341 aaactttttc ctgactctca atcgaaaaag caacttctct cttttttaat aaacaaacaa
    29401 cttcctttat caatctttga ttaaaagatt gattataaag taattcacca tgatactgaa
    29461 tgtaattacc tcctcctgca atatatccat caactcctaa tgataaaaca tcatcttgta
    29521 ttgtacccat acttcttcca gtacaaataa caacactgca atgattcttt tgacataaac
    29581 gtatagcatg ctttgcagat tctgggattc catatacctc atctctaagc gtaccatcta
    29641 tatcaagtat taataatttg tacaatttca tcttcctttc ttactatcaa aatcataata
    29701 gcattcaaaa aaaaagatat caatattttg atatctttta aaaaatatgt tcatttttag
    29761 cacaaatttt cattttcggg gaatatgttc actttctaaa tacatcttgt atttaatata
    29821 aagcagttca attaaaataa aataaggtgt tgttacatcg tagtccagtt gtttatctac
    29881 agaaatagat atagattgaa tatacaggtt ttcatcacat aatcttgcta aaggattact
    29941 tatcattttt gtaatagaaa ccatataaat tcctttcatt ctcatttctt tagcaaaatc
    30001 aataattgta gatgcatctc cattcaatga aataaagaaa atcatatcat ctgtttttat
    30061 aaaatgatta agtgcctgaa tcatatcata accataaaca tcatatataa ttttccctgt
    30121 tggtaagaaa atccttttca tctctttagc aactctttcc tgagaataac cttctccaaa
    30181 gacgattata cgatttgcct ttttcattct ttcaaacata atcgaacaat ccttcttctc
    30241 tatatcatct atcaccttat tataacaatc cattaattgg tgtttacttt gatttttata
    30301 ttctacttct gtttcattta agcgtataat aactcttaat tcactatatc caggtaattg
    30361 tagtttttga gcaaaacgag aaagtgcact tgtagatata tggtatttgt ctgcaaattc
    30421 atctatagaa agtttaatac aatcttcttt atgattaaga atacactcac agatatactt
    30481 atcatttgct gtaaatgaat tataatattt attgaaaagt ccttcaattt tcattctttt
    30541 ctccttctat actctatgta attcatatga agcaaatcta atagagcata aaatgctcct
    30601 acgacttcat aagatatagc ttgtaatgta tcaagttttt gcgtttcaac atacagatta
    30661 tactcacaaa gtgttgcaat tgtattatta tcaagcctag ttaaagaaat cgtatgtata
    30721 tgattgttga taaattttgc aatttcaatt cctgcttttg tttctccaga caaagaaatg
    30781 ataataaata aatcactttt ttgaaatgat tctctcataa attcaatttc acctatatca
    30841 aataagtcaa taacacattt acctactgaa agaaatattc tctttatttc ttgagctaaa
    30901 cttttctgtt cattacctgt cccataaata taaattgttt ctgcatcata tattatttta
    30961 caaatatctt gaaatgatat tttttgtaat tcattcatta atagtcgata attctcgcaa
    31021 acatcatgaa aattattatc attattaaca aattctagtt gattattttt aagtaaatac
    31081 tttaaatcag agaatgaatc taatccaatt tttctacaaa gccttaataa agtagctcta
    31141 gaaacattac attcatttgc aattttttca cacgaaaaat tacggtattc tctttgacaa
    31201 atcaatattt gtttaataat aattttatca ttttcattta aattatcata attttggtta
    31261 actaacgatt ctaatctcat tttttccact ccctaaatat tattttaata tacattagtt
    31321 gctttttcta gggaagagtt ttaaataata aggataaaat aatcatttga ttttattttt
    31381 attaaaataa aaataacctg ctaaaagcag gcaccaaaaa gtacttatcc tttcgaacat
    31441 gtactttaga tattgctttc ttcagaagct tcatctcttc atactctaaa atagagtttt
    31501 ttctaactca aaagtgtttt ccatggtaga aattacttta attcatctgc catttacttt
    31561 ttatcttatt taataattac tattacttga atatttactt ctttaagtaa atttcatagt
    31621 taacaaagct aaaactatta ttatagatgt taaaatacaa aattgtaagt attgttataa
    31681 atatgcttac agctacaaat atacatgata tattaaaaag aagctgtaaa ttattatcat
    31741 acatacaagc aactatgcct ctattaatcc atgttaattt ttattattta atacaaggag
    31801 ttccatgaga catacatatc cattcatatt ttaaattatc caattcgctt atagatttca
    31861 tcatcttttt ataatcccaa ttccatggat taggataagg aactatattt ccattcttat
    31921 ttttgactaa atcacctgca aataatacat cttcaaaaat catgcagaca tgccctggag
    31981 tatgaccagg agtatggata atttttatat tcccaatctg catattctct ccataaggtt
    32041 caacatcctt aatgagcctt ctggaaattg cctttccaat aaacttctta aacccaggtc
    32101 tatccttctc tcctataata aaaggtatat cctctacatg agcccatact tttgctcctg
    32161 ttttttcttt caataattta atattagata tatggtcaac atcatgatga gttaataaaa
    32221 tatgcttaat atctgtaagt ttaatgccaa gtgtttttaa ttctttaatt atattttccc
    32281 ccataaaagg aagacctgtg tctataagaa taatttcttt atcaaacaca ataaaacaat
    32341 ttgagccacg agtactatct aacattaata cattttcttt tatcttcata aataaattcc
    32401 ccttatttgg tattttacct atataattaa ttaataaagt tataaatagt tataatactt
    32461 gatatt
//
LOCUS       DAEQCW010000037        32386 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.037, whole genome shotgun sequence.
ACCESSION   DAEQCW010000037 DAEQCW010000000
VERSION     DAEQCW010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 32386)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32386)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32386
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.037"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     regulatory      191..281
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            693..1010
                     /gene="flgB"
                     /locus_tag="KRO40_001730"
     CDS             693..1010
                     /gene="flgB"
                     /locus_tag="KRO40_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgB"
                     /protein_id="HBH2092551.1"
                     /translation="MNTYDIIKMGLDATNLRSQTIANNIANINTEGYKRHYITFEETL
                     NDAMPKIEEKTDNSKGLRVDGNNVDIEEEKVNQAMATLQYNALISFANGKIAMTKSII
                     SGR"
     gene            1018..1422
                     /gene="flgC"
                     /locus_tag="KRO40_001731"
     CDS             1018..1422
                     /gene="flgC"
                     /locus_tag="KRO40_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgC"
                     /protein_id="HBH2092552.1"
                     /translation="MSVFSGMRISASGLTAESLKMDIISSNVANINATRGPNGEAYRR
                     KVVSFEENYDNKLGMLGVKVTSVEDDKSPLKEVYDPSHPDAKPNGYVEYPNVNILVEM
                     TDLITASRAYDSNVDTLNAQKSMISKALEIGK"
     gene            1432..1749
                     /gene="fliE"
                     /locus_tag="KRO40_001732"
     CDS             1432..1749
                     /gene="fliE"
                     /locus_tag="KRO40_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein FliE"
                     /protein_id="HBH2092553.1"
                     /translation="MPITQINNLMQGAKLDNLIGEAKPLTLNNKEEKKNFEDVIIDTI
                     DKVNFQQVTADDMKEKFIKGEDVSMHEVMLIGQEAQLSMQYLIEVRNKIHDAYQEMNK
                     VQI"
     gene            1774..3324
                     /gene="fliF"
                     /locus_tag="KRO40_001733"
     CDS             1774..3324
                     /gene="fliF"
                     /locus_tag="KRO40_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar M-ring protein FliF"
                     /protein_id="HBH2092554.1"
                     /translation="MITSFKNKIKEQVAKSRTKISSLKKGTKIALGIGVIAICLALVF
                     TAISASKNKYAVLFSELDAQDAADISAELESKKIDTKVKGSTIYVPRTEVDKLRLELA
                     PSLTGGSKGFALMDDSSSIGLTDEEFQIKKQRMIQGEIEKTIKSFPQVEDTRVHITFG
                     ESSVFEKEAVPGSAAVYLMLKPGTTLEKNQIKSVMALISGSVTNIPEKNVQVIDNKMN
                     LLSEGILEDENVDENNQPINSGISVDKNKASEQALNKQLEKSILEMLEPIFGKGKVKA
                     TVNADLSFDTAEKTEIKIDPDKVAIKETRSKNSSKSAANNVQGVDANMNNQGNNNGTN
                     TEDSLDESFEYETGKIETHTIVAPGELNRLTASVAIDGKIAKGVQADVEDIVNNAIGM
                     DGARGDTLSVVSMVFDPEGKKEAKQELEEIKKEGFKKNIIKAVIGVVAVIAVGAIGYL
                     IYKKRSEREDMDYEDEDYISKSDSVDRKDNPLLGDDPELTLEEAVKMYAEEKPDQVTE
                     IIKTWLNE"
     gene            3337..4407
                     /gene="fliG"
                     /locus_tag="KRO40_001734"
     CDS             3337..4407
                     /gene="fliG"
                     /locus_tag="KRO40_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor switch protein FliG"
                     /protein_id="HBH2092555.1"
                     /translation="MSTEITNVNAFDLSDINESDKNEKVEGEGLKKAAVLLMTLGPNV
                     SSDIIKSLPDKQVQKIGLEIANISSIASKERREILKEFVEINRAKDYVIEGGLEYARE
                     LLSNALGNVKANKLLEGISINTSTKPFKHIIKLDVKKILEILRNESAQTIAVLLAHME
                     PENGAEVLSYLDFDLQNEVAMRISSMGSISPEVIKVIESSLEDKLHSISGDDFNDYGG
                     VSTLVQILINSDRKTEKNILGTIEEQNPDLAAQIKSHIFVFEDIVKLDDISIQKVLKE
                     VTMKDLVYALKGVDDEISDAIYRNQSSRAADALKEEMEMVGVIKVTQVEASQQKIANI
                     VRKLEREGAITIVRNFGGDFVE"
     gene            4400..5131
                     /locus_tag="KRO40_001735"
     CDS             4400..5131
                     /locus_tag="KRO40_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliH"
                     /protein_id="HBH2092556.1"
                     /translation="MNNKIIKSKKALYKGVLDLTIIDKVRVGESNVNKENDCRFRDEV
                     IKEAIESAEIKKNEILEEAKINAQNIEKQAYEKGYSQGQKNGYEDGYKESYDEYTQKA
                     KDEADFIKNQANLILLQANEKMTEYIKEKNKEIVRLAINMASSVLKKHFEDEESMSDL
                     LKQIIQDYEGSSSFIVRCNSFYKDNIEKEFELFKEETSLKSSVFVIADDSIDKGNAII
                     QKENGRIIVGIDCAMEKLKEELLGE"
     gene            5135..6454
                     /gene="fliI"
                     /locus_tag="KRO40_001736"
     CDS             5135..6454
                     /gene="fliI"
                     /locus_tag="KRO40_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein export ATPase FliI"
                     /protein_id="HBH2092557.1"
                     /translation="MYKTDISIDFDKINKKIENLELTISEGRVKKIIGLTVEVEGIKA
                     FVGELCVIYNQVNKPVNCEVVGFKDKEVILMALGELTLIAPGCKVISKGIPLSVMCSD
                     NLLGKVLDGLGNPIDNSDAVLGDRYNLNNEPPDPMKRKKIRNIMETGVRAIDAFTTCG
                     EGQRIGIFAGSGVGKSTTLGMIARNAKADVNVIALIGERGREVLDFIDKDLGEEGMKK
                     SVVVCATSDKAPLVRLKGALTATAIAEYFRDQGKKVILMMDSVTRFAMAQREVGVAIG
                     EPPAQKGYTPSVFAMLPKLMERTGTSDKGSITAFYTVLVDGDDFNEPIADTTRGILDG
                     HIVLSRDLANKNHYPSIDVLNSLSRLMNEIASKEDIKIASFARDMLAEYREAEDLINI
                     GAYASGTNKKIDEAIYYHEHIINFLKQGINEKSSFNETISSLRRVFE"
     gene            6485..6931
                     /gene="fliJ"
                     /locus_tag="KRO40_001737"
     CDS             6485..6931
                     /gene="fliJ"
                     /locus_tag="KRO40_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012815984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export protein FliJ"
                     /protein_id="HBH2092558.1"
                     /translation="MELDKNFKFRLQKVLDLKVKDEEEIKMEFAKIQQKKIDIETNLE
                     NLESNYSKYSISKNNDSIQNQKITINYLLALNNSIMDLSEELDKSTNELEKARKQLIS
                     KQIERKSLEKLKEKKYGQYYKEENLKEQNTNDEFASMSYLRNRQVL"
     gene            6960..8165
                     /locus_tag="KRO40_001738"
     CDS             6960..8165
                     /locus_tag="KRO40_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-length control protein FliK"
                     /protein_id="HBH2092559.1"
                     /translation="MKIQADSYNIIKDIGDRKSSPKNKNIKNNKFEDNLYKATDHKKV
                     KDRREVSKQNISSDKPENSDNECHLDEDKSNHLEDENTYEKDCSKNNEALQQLLNLLK
                     DNYKKDKDINTILNNIEKLSISDELKQELKLNKNILNKIANQNSELNKANINNSNDIE
                     NLDIVKLRELLEDNANKDIEVITKTTENDTKNIDLYSFDSNRMDNLNSNKQKDDSSDI
                     LEKLAGVNGNKSGNFGQVINKNVDMNKIKNDNVNLKQIESNVMDDSIKAIKHMKTNDI
                     QELTIKLRPKELGDMNIQLLKDGESMRAVVTVFNKDVFDSINKNIADLKQHLELTNVN
                     IKDVSVQMHSDNTNTSDTFDKAFEQQNRQNNQENMSKKNTNDKHNNVVIEDDIKENTI
                     DDDRVDLLA"
     gene            8183..8791
                     /locus_tag="KRO40_001739"
     CDS             8183..8791
                     /locus_tag="KRO40_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlgD"
                     /protein_id="HBH2092560.1"
                     /translation="MYGIATALAGTKGNYRSNNLSQLERNINDIANKQVRSKGNQTVT
                     DNGTPIIGQGDDADKDLFMKILVAQMGNQDPMNPQDPTEYVSQLAQFATLEKMSAMNE
                     KLDVLLALSNSTLINSALSMATSLIGKEVEVSGEEKEDENIVGVVKSTYIKDGEVHLE
                     LEVDGSDKTVGVKYEKLLKIGEVDENSGEENDSSEHESPEEA"
     gene            8818..9801
                     /locus_tag="KRO40_001740"
     CDS             8818..9801
                     /locus_tag="KRO40_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein"
                     /protein_id="HBH2092561.1"
                     /translation="MIKAMYSGVSGMKANQTKLDVIGNNVANAGTTSFKKSSARITDS
                     FYQTVLYASAPTAALGGTNLGQVGVGSKISSINKDMVQGNVQPTNRPSDLMIDGDGYL
                     PVVRQGTVMYTRDGSFNLDTGFKAADGALKNIKGGRLVNGDGYMLQGMIYDGEYKADT
                     GEFVKKGDAKGKEPIVIPLQSISPKDGTVQNVLEYNISKDGTVEFLLSDGQRTQFVYD
                     IPDGAKVGDTPAGIDKLKGTIQKVQTYAFQNPAGLDAEGGNLFKPSANSGDPQIAGAT
                     GTIIQGAIEASNVDIAEEFTEMIIASRSFQANSKIISTSDEILQEIINLKR"
     gene            9814..10017
                     /locus_tag="KRO40_001741"
     CDS             9814..10017
                     /locus_tag="KRO40_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar FlbD family protein"
                     /protein_id="HBH2092562.1"
                     /translation="MIRVTDLNGRKYILNSDLIVRIDSVPESRILLTTGEKNLVKESV
                     DEIVDKVIKYKRKINVGYIRSEK"
     gene            10017..10835
                     /locus_tag="KRO40_001742"
     CDS             10017..10835
                     /locus_tag="KRO40_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MotA/TolQ/ExbB proton channel family protein"
                     /protein_id="HBH2092563.1"
                     /translation="MKKTDSLTFIGLIVSTVLVLVGAAKGSSSGLKNFFDVSSILITV
                     LGSFGALMITFTIDDIKLIKNALQYSFKTMSVSKLDLLEQFKTLSKKARKEGLLSIES
                     DVMGIEDPFMKKGLELCIDGLEINEIRSILELEIDSVEDTNNRYSKLFKTWGTFAPAF
                     GMLGTLIGLIQMLADLTSPDLIASGMGKALITTFYGSLLANIALNPIAYNIDEKTEKE
                     IYVKEMMLEGIISIQSGESSIVVEERLATYLSNNEKLEIMKSNKNTERAMSNGA"
     gene            10825..11520
                     /locus_tag="KRO40_001743"
     CDS             10825..11520
                     /locus_tag="KRO40_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH2092564.1"
                     /translation="MARKKNKKKDEINPDAWLATYADTITLILTFFVLLYATSVVDME
                     KFKNIADALKGQFSGTSIFSTGSSTSEKSPIDSVLVDKNDKSNLEQDLKDKVNNSNLQ
                     NSVTVKDDSRGILLELDDSILFDSGISELKVDSKATLNKVYDMIKMMKNKIVIEGHTD
                     NVPVKSSTHESNWDLSSSRAVSVVRYFVEEKGMDPRLFSATGCGEYQPLVSNETAKGR
                     AENRRVNILITID"
     gene            11532..11975
                     /locus_tag="KRO40_001744"
     CDS             11532..11975
                     /locus_tag="KRO40_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body-associated FliL family
                     protein"
                     /protein_id="HBH2092565.1"
                     /translation="MFKNKKIIIIILILIIFSAGAGFFILGEGGNKQVDKIAGLFIPT
                     GKGKDEVKTENLDLEEMVLKLADEGVRYLKVSITVSYDSSYKDIEKNTPLIRDNIINC
                     FMAKRADDFTADNLKNIKEEIKNTLNIQLGENVIQNIYFTNIVVQ"
     gene            11990..12364
                     /locus_tag="KRO40_001745"
     CDS             11990..12364
                     /locus_tag="KRO40_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliZ"
                     /protein_id="HBH2092566.1"
                     /translation="MILYLLKILICIPIILILIVLSLKISQGTLLKKYNDKYVKILDI
                     VNISKNNSIIILKIGEEGCIMASSSSSMSKIKDLTKEEILKIENDIKERNFKIQDFKM
                     ERIKKKYDFSRYIGKFTKKEDK"
     gene            12365..13030
                     /gene="fliP"
                     /locus_tag="KRO40_001746"
     CDS             12365..13030
                     /gene="fliP"
                     /locus_tag="KRO40_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425215.1"
                     /note="The bacterial flagellar biogenesis protein FliP
                     forms a type III secretion system (T3SS)-type pore
                     required for flagellar assembly; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar type III secretion system pore protein
                     FliP"
                     /protein_id="HBH2092567.1"
                     /translation="MELLSKLPLADVPYTSSMQLFLFLTALMFLPFVMFMMTSFVRIV
                     ISLSFLKSALGAQQAIPSQILVGLAIVLTIFIMRPVLNEINEKALQPYMKEEVTMEEA
                     MKEAEGPIKEFLLTQTRQTDLDLFVEQAGLKEKKLTRENIPLSVVVPAFAISELKTAF
                     QIGFLIYIPFLIIDLVVASVLMSMGMFMLPPVMISLPFKLLLFVMVDGWNLIVKTLIL
                     GFG"
     gene            13043..13312
                     /gene="fliQ"
                     /locus_tag="KRO40_001747"
     CDS             13043..13312
                     /gene="fliQ"
                     /locus_tag="KRO40_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliQ"
                     /protein_id="HBH2092568.1"
                     /translation="MSEFMIMSVLKNGMFTGAMIAAPVLIVSLVVGLLISVFQATTQI
                     QEQTLTFVPKLIAILLVVAIGGSWMLHTLISFTSEIFNMISLITK"
     gene            13324..15138
                     /locus_tag="KRO40_001748"
     CDS             13324..15138
                     /locus_tag="KRO40_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fused FliR family export protein/FlhB family
                     type III secretion system protein"
                     /protein_id="HBH2092569.1"
                     /translation="MIFVFIRIVAFFGTLRILFPAGTPALFKSLFAIIISILISSTMQ
                     IEYATNIDNIVLFTLYGINETITGIMLGYITNLCFYSIRMAGSMMDQQMGLSMINMFD
                     PNSMTQTTLIDNLMNWTALMIFFSMDGHHVLIRGIRYSFELIPIGKPFVDNNIDYIIN
                     IFVQCFLTGFKIAIPIVLCLLMADFILGLISRSVPQLNVMIVGMPLKILVGIALFIIS
                     IPLIVNQISHLLSQIPKMYEGTFALAPMFFMGSTDKTEEATPKKKGEQRKKGNIAKSR
                     ELPVAMTLLAFTLLVPTLFSYVVDTLKSSLNYFLSLDFYMNINYSNLEKLVIAGLMDF
                     FKIFLPIAIPFLVLGIIANLFQVGILFTGETLKPNLSKLNPVSGFKNMFSMRSLSTLI
                     KDIAIISILAYIGYTFFQDNYLDILKLGNIYLPTLMYTVKDLVYSILSKICVAMIAIA
                     VADYVYQRYSHKKQLRMTKQEVKDEYKNSEGDPEVKAKIKQKQRQISSQRTMQAVPSA
                     TVIVTNPTHLSIAVRYEKGKDQAPVVVAKGADYLAFKIREIAKGNDIPIIENKPIARL
                     LYKQVEIDQEIPEDMYQAFAEILVAVYKIKNRYKVPKR"
     gene            15147..17222
                     /gene="flhA"
                     /locus_tag="KRO40_001749"
     CDS             15147..17222
                     /gene="flhA"
                     /locus_tag="KRO40_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhA"
                     /protein_id="HBH2092570.1"
                     /translation="MNKFNLKENMDVIVAFGVVGIVLMIIVPLPTFILDILLAINISL
                     SVLILLMTLFTTNVLDLSIFPTVLLVTTLFRLGLNLSSTRLILTQGYAGEVIEAFGSF
                     VVGGNYVVGIIIFLIILIVQFVVITNGSGRVSEVTARFTLDAMPGKQMSIDADLNAGV
                     IDDKTARKRRKELQQEADFYGSMDGANKFVKGDAIAGLIVTAINIIGGIVIGAVMLNM
                     TLMGAAQTYVRLTVGDGLVSQIPALLISTSAGIIVTRASTDENFGGLVGKQLTAIPKA
                     VMMTGCVLIVLGMMPGLPKPAFFSLGIGAIAAGYFLGREKKDTLEDLEFEKPDMVNPD
                     KNEVEDVTNLINVESIEVEIGYGLISLADESAGGDLLQRIASIRRQCAIDMGIVVQPI
                     RIRDNLQLNPNQYNIKIKGNVVGGYEIMPNMVLCMDPMNQGFSIFGIKTIEPTFGIEA
                     LWIESDKVEDAELKGYTVVDSSTILITHLLDIIKSNAHELLGRQEVKTIIDAARENYS
                     AVVDELIPDLMTLGEIQKVLKNLLREKVNIKDRVTILETLADQSRNTKDIELLTEYVR
                     IALARSICNNLVDDDKTIVVATLSPETEELISNNLQRSVNGTYPAVDPENTNKIFESI
                     QEVMSNVYFNHNIPVIVVSPKIRAPFRKLVEIVYPNLTVLSLNEIPNDIKIKAEGVVS
                     IYDDEKVYS"
     gene            17197..18213
                     /gene="flhF"
                     /locus_tag="KRO40_001750"
     CDS             17197..18213
                     /gene="flhF"
                     /locus_tag="KRO40_001750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhF"
                     /protein_id="HBH2092571.1"
                     /translation="MMTKKYTANTIQDAMNLAKMELGDNITLIDKKEVRKSGIQGIFS
                     KKDIELTIGWEKRENIEQKDLKREIEQLKLIINNMGFDNKNDNDIDKICKNLLSLELN
                     EEIVESIRIDLQEMKFNGIDTSKNLVEILKKKIKIENQVINGKIALVGPPGVGKTTTI
                     AKLAAKLVFEENKKVGVITIDTYRIGAVEQLKIYTDIMNIPFKGVISPDEMELALDEM
                     KDCDVVLIDTTGRGYKNSMQILEIKNLIDKAETDNIHLVLNCTTRESDTKAIIDSYRN
                     VNFKSLIITKLDETITYGSIFNIMNYAQKPISYITTGQNVPDDIIKPNEDKIIRLLLG
                     VESI"
     gene            18210..19088
                     /locus_tag="KRO40_001751"
     CDS             18210..19088
                     /locus_tag="KRO40_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MinD/ParA family protein"
                     /protein_id="HBH2092572.1"
                     /translation="MIDQAQILRKMAMEKRGLDEFIVENENVPKIITIASGKGGVGKS
                     NLATNLSICLTKLNKKVLILDADIGMSNIDIIMGVNVKGTIIDVINGEKNIEDIISQT
                     KYGVNIISGGSALNHIEDFTEAQRNKFIHSIEQIHDVDFIIIDTGAGMSKSLLSFIYC
                     STEFFLITTPEPTSLTDAYSLLKAISNFGIKRSANIIINRVIDLEEAKSTYKRIKMVV
                     DKFLNLNLELYGYIIDDKKVSLCVKKQIPFILEYPTSIASKCIIAIAKRMVSQSREDI
                     VDNKSFLRKMFSIFKS"
     gene            19102..19803
                     /locus_tag="KRO40_001752"
     CDS             19102..19803
                     /locus_tag="KRO40_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliA/WhiG family RNA polymerase sigma factor"
                     /protein_id="HBH2092573.1"
                     /translation="MNREELIKENMPLVKSIARKFFIPGKGFEYQDLVNSGVIGLIDA
                     INKFDAEKGAKFSSYSYIKIKSAILDEIRNQSPISKHNLTKVNKYNRVVEKLQSKLLR
                     EPTSYEIAKELKVSEKELHDIESNIDMLNIVSLNYVIFEDTNETVQDVISDREEEAPE
                     NIIEEEEKLEILSKAISNLNEREKLILSLYYYEDLNLKEIGKVLGVSESRVSQLHRKS
                     IRNLRNKIKELKYSI"
     gene            19819..20241
                     /locus_tag="KRO40_001753"
     CDS             19819..20241
                     /locus_tag="KRO40_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBH2092574.1"
                     /translation="MIQIILIVVSILIIVTIVINLHKESKNKDNRYFDKIFEQEYEAN
                     DRLIIAEKRRFFLDKVLAEKRINSHIKVYENYNLIKANEERKENIFIESKKEVRQENE
                     LSLKVKHLISSGYDDVEICKMLDIGKGELLLIRSCYKI"
     gene            20226..20411
                     /locus_tag="KRO40_001754"
     CDS             20226..20411
                     /locus_tag="KRO40_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBH2092575.1"
                     /translation="MLQNIRILLCDKKVFLGIGIGILISTLCIMLFSNNDMSKAEIEK
                     KARALGMKYTSEMKVLE"
     gene            20452..21225
                     /gene="flgG"
                     /locus_tag="KRO40_001755"
     CDS             20452..21225
                     /gene="flgG"
                     /locus_tag="KRO40_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBH2092576.1"
                     /translation="MIRGLYTAVSAMITNQQKQNVVVNNLANMDTNGYKSKQLLTKSF
                     DELKLEGYNNYANGTKQKQIIGDISPGISMDETITNFNQGPIKTTDNKMDVAIQGKGF
                     FLVSDAAGNQFYTRNGNFRTDNQGDLITSEGYYVLGTNTATGAVGHINVGNQKFEVAK
                     DNTISLDGNAMYKFNIVDFNNYNNLKKEGDNLYSGGGAMKVNNALTIQSAIESSNVDM
                     VSEINNMMTISREYEANQKIIQAMDSKLAKIASEIGSVR"
     gene            21246..22007
                     /gene="flgG"
                     /locus_tag="KRO40_001756"
     CDS             21246..22007
                     /gene="flgG"
                     /locus_tag="KRO40_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBH2092577.1"
                     /translation="MYTMFYTSKTALSANQSKLDIISNNIANSDSTGYKKINMEYSDL
                     VDEVLNRPSYPTNGNDISTGTGAKATAPMRNYEQGALAPTDSKSNLAIDGEGFFRVIR
                     KDGTYAYTRNGGFNVDALGKIVDDNGNILDVQFDAGYNYNNTNIDSTNLTVSRNGELF
                     VDNKKIGKINLYQPIGTQNFISEGDSLFVATDAAQIKQVEKVDIVQGYRERSNVSLQE
                     EFVDLIATQRAFQMNSKGIKTADEMWQIANNLRAK"
     gene            22030..22911
                     /locus_tag="KRO40_001757"
     CDS             22030..22911
                     /locus_tag="KRO40_001757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH2092578.1"
                     /translation="MNDMKEYDFGKPQSYSRENLTCLNFLLAEFCKKYKNYIIYELKC
                     NSSMVVDSIDQVNYQTFLDRVTSSCVVVQNAMEPVMKNFSFRIDRSVADMWIDITSGG
                     TGVVKDNDRELTELDKKVLLHLMDDLVRNMHLFEGFENIQVLDTHTHINLPQLCSPTA
                     PVCVVDLKVLNDNEYIGSVSLCFPYNGLEALLESISVIEFFDNDVGDDSEEFTQKIYN
                     SVSNIELSVIAEIGKVSINVEDLLKLEVGDVIVTNKKINDYIDIFVENSKSYTATPGF
                     ISSKKGVKINDAVGKEV"
     gene            22914..23288
                     /locus_tag="KRO40_001758"
     CDS             22914..23288
                     /locus_tag="KRO40_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBH2092579.1"
                     /translation="MDNSNLISDEEAKMLLNDKVESEVDGDDELALDVSEVNRNNIQR
                     ILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVV
                     DLNFGVKITSIVSEEDMVKSLV"
     gene            23320..24723
                     /locus_tag="KRO40_001759"
     CDS             23320..24723
                     /locus_tag="KRO40_001759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH2092580.1"
                     /translation="MVLILNLNDIKKDILKLNKKDSCSLYNESINNINNNCISTGLKF
                     LKQARDLNPDDVDILNLTGLVNLLKCNFDDAVESFYKSSLCEKTALCEKYINMLTSEE
                     FLIFFEKYNQLIRLINKGMYKEAIQGFKLITDQYCDLIEPYELLALLYDKEEEYIKFD
                     ECLEVLKIIDKENYLLNQENNTLYMYNSANIQTKSNIKVDDYKNEFLHKSSSNHKIND
                     YNDVTKEKSSSKNQKSSDSNKKKSIKKNKYLYIAIILGILLVGQSIYSSYKMNNLTDK
                     ISKNNETKNEESIDSNLTKKENNIEENEDMSKASNINKSNKNINKEDDVKSKKNTVEN
                     EDDKDSDLFTEDELMSKANTLKSEKKTKSSIQLYKKVADIGENKGNTSEATYQVAILS
                     EKLKDYKTAEEYYKMYVENYSEKDAYFDESYYNLGMMYYNNGDLKNSKLTLKKLVNKV
                     PNSMYNNSKVKEILKEE"
     gene            24839..26776
                     /gene="htpG"
                     /locus_tag="KRO40_001760"
     CDS             24839..26776
                     /gene="htpG"
                     /locus_tag="KRO40_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone HtpG"
                     /protein_id="HBH2092581.1"
                     /translation="MEFEKGSISIHTENIFPIIKKWLYSDKDIFIRELISNGCDAVSK
                     HKRLVSLGEISENKSSDYKITVSVNKGEGTLKFIDNGIGMTEEEIKKYINQVAFSGAE
                     DFFNKYKDKMEESNDIIGHFGLGFYSAFMVSKKVQIDTLSYTEGATPVRWISEGGTEY
                     EISESDARNDRGTTITLFIDDDSKEFLDEFTVRGIINKYCSFLPVEIYLEDVERLERE
                     AKEAEEKAKKQKEDGKEEIVDAKVIEPLNDTNPLWLKSPKDCTDEEYKEFYRKVFNVF
                     DEPLFWIHLNVDYPFNLKGILYFPKLKNEFELTEGKVKLYNNQVFVADNIKEVIPEFL
                     LLLKGVIDCPDLPLNVSRSFLQNDRDVSKISKHIIKKVADKLKSLCKNEREEYNKFWD
                     DIQIFIKYGCLKDESFYEKVKECILFKTIDDEYITLQDYLEKCKDKHENKVFYVSDKE
                     QQSQYIKLFKEYDLSAVVLNSSIDTHFISFMEYKENGVKFNRIDADLSDVLKDKNENK
                     DSEENKEEIAKIEGLFKEAVGERVKNYSVEGLKNEDTPAMVLVSEQSIRMAEMQSRFA
                     GMDLGMNFEEEKTLVINENSPIIKKLVSLKDDEEKKDKITLICNQIADLALLSNKELK
                     PDELDSFVQRSNKLMSLLIEL"
     gene            27164..28294
                     /locus_tag="KRO40_001761"
     CDS             27164..28294
                     /locus_tag="KRO40_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH2092582.1"
                     /translation="MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKT
                     GLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGVEIIKSTGCDCVLGLGGGSIMDA
                     AKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
                     SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYG
                     IELISENLIKVYNDVNDLEAWEKITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMH
                     GKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRNFLKKIDLDIKLSDL
                     GIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL"
     gene            28521..29543
                     /gene="splB"
                     /locus_tag="KRO40_001762"
     CDS             28521..29543
                     /gene="splB"
                     /locus_tag="KRO40_001762"
                     /EC_number="4.1.99.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore photoproduct lyase"
                     /protein_id="HBH2092583.1"
                     /translation="MFNPKRIIFEKGTLDTDVGKKIYNKFRDNKDVEIINISSNRIKE
                     HIPGENLYEQYRSGKQTMVVGIRKSLKFQTCKPSANYQLPLVSGCMGRCEYCYLNTQL
                     GDKPFIRVFVNVDEILEQTKKYIEDRKPQVTIFEGAATSDPVPVEPYTNSLKKTIEFF
                     GREEKGRFRFVTKYSDVDSLLDAEHNNHTEIRFSINTPRIINEHEHYTASANKRIESA
                     VKLARAGYQIGFIIAPVFLYEGWKEEYKNLIISIKEALPKDFDKKIIFEVISHRYTTK
                     AKNRILEIYPDTLLPMENEDRKFKYGQFGYGKYVYDKEQLDDMKEFFLKEINGVFKNS
                     LIKYII"
     gene            29725..30636
                     /locus_tag="KRO40_001763"
     CDS             29725..30636
                     /locus_tag="KRO40_001763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2092584.1"
                     /translation="MHAWESIQITLDLIEANLSEEISINELANKANLSPFYYQRLFKR
                     LVNKTVMEYIKLRRLARASEYLAEHKNRILDVALNFGFASHETFTRSFKKAYGLTPEK
                     YRANPVKLNHFIKPELILNYAMVDEGVPLIADDIVIEVNRKTLSNPRTFVGIEIEVPI
                     CQLVGGETTGIAIVEELWMKLGSQRHNIPNQIPGGNEFAALYMGNAKEGNCMYMAGVE
                     VESGTSVEGYSTFELPAKEYLVCGFEAENFNELVNSAVFKADKFMERWMKKHNLTTTD
                     FAIEMYYPTTPEAAYLEHWIVPVPIEQ"
     gene            30651..31067
                     /locus_tag="KRO40_001764"
     CDS             30651..31067
                     /locus_tag="KRO40_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH2092585.1"
                     /translation="MNWQDAFFQDTKPKFEQINEFINNPLWDKLNKTLVSTYNVEPKL
                     EYSKCSMQRGWNVKYKKRGKSLCTLYPQEGYFKALVIVSESNRVEVDLFINTCCDYIK
                     KIYNEVNFFNGSKWLMIQVDSLLVLNDMLELIKFRA"
     gene            complement(31167..31559)
                     /locus_tag="KRO40_001765"
     CDS             complement(31167..31559)
                     /locus_tag="KRO40_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092586.1"
                     /translation="MSINTEKNITKNVEELTCPIRYALDIVGGKWKLPIICMLAVENP
                     IRYSSIKRKLDGITNTMLAQSLKDLESTGIVHRKQYNEIPPKVEYTLTSKGKSIVPIL
                     QQFANWGATNMQEKNTCGLSCKECRKIK"
     gene            31700..32095
                     /locus_tag="KRO40_001766"
     CDS             31700..32095
                     /locus_tag="KRO40_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBH2092587.1"
                     /translation="MKALEFLNKARVYYLATVDENNQAHVRPLGFVMEYNGKLTFCTS
                     NQKDMFKQLIFNPKVELCCIDQNLNTLRILGEAVFVTSKETQAKALEIMPSLGQMYSV
                     GDGKFEIFSIDKAKVSCCSMSGKKIDVEL"
BASE COUNT        13275 a         3428 c         5928 g         9755 t
ORIGIN      
        1 tagaattaag atgagatttg tcttatattt ttataaatta aaaatatttt caaagagttt
       61 attataaaat tgtaaactat agtgtttata atctttgtaa ttattggtaa ttaaatttaa
      121 aaaataaaat atttaattat acacaaaaaa gatatttaaa aaatttgtta tttattgtat
      181 acttaagtta aaactaaata ggcaaatcta gagaaatcta gtgacgcaaa gctataggga
      241 ctaaggttta tatacataaa ctatgtcagc cagttgccaa aaagagtcct aggtgtattg
      301 tatacctaag aaaagtctat aatgactgcc tttttggcag tcattttgtt atggaaaaat
      361 cactttattt cagtagaaaa tacacataat aacatatttt accaattata acataaaata
      421 aagaaaaatt atctcaaaaa gttactattt tacaaaaaaa aatgacttct ttatttattt
      481 aaattaatcg catttccatt acattaatac aataatgtat caatttagta agaaaactaa
      541 tattttttta atgaagtccc atgaaaatat aaaaaaattt taatatgtat ttaaatattt
      601 cttcgaaaag ttgctctttt ttgtaatata gcaacttcat tttttttatt aataaacaaa
      661 atagataaaa tatattttga ggaggggtga gtgtgaatac atatgacatt ataaaaatgg
      721 gattagatgc aactaatcta agaagtcaga caatagcaaa taatatagca aatataaata
      781 ctgaaggata taaaagacat tatataactt ttgaagaaac actaaatgat gctatgccta
      841 aaatagaaga aaaaacagac aattctaaag gtttaagagt agatggtaat aatgtagaca
      901 tagaagaaga aaaagtaaat caagcaatgg caacattaca atataatgct ttgataagtt
      961 ttgcaaatgg aaaaatagca atgaccaaat caataataag tgggaggtaa ttagaagatg
     1021 agtgtgttca gtggaatgag aatatctgct agtggattaa cagcagaaag tttgaaaatg
     1081 gatatcatat catccaatgt agctaatata aatgctacaa gaggtccaaa tggagaagca
     1141 tataggagaa aagttgtttc atttgaagaa aactatgata ataaattagg tatgctagga
     1201 gtaaaagtta catctgttga agatgataaa tcacctctta aagaagtata tgacccatct
     1261 catccagatg caaagccaaa tggatatgta gaatatccaa atgtaaatat attggtagaa
     1321 atgacagatt taataacagc ttcacgagca tatgattcta acgtagatac attgaatgct
     1381 cagaagtcta tgatatcaaa agctttggaa ataggaaagt agggataaat tatgccaatt
     1441 acacaaatta acaatttaat gcaaggtgca aagttagata atttgattgg agaagcaaag
     1501 ccattaactc ttaataataa agaagaaaaa aagaattttg aagatgtaat aatagatact
     1561 atagataaag ttaattttca acaagtaaca gcagatgata tgaaagaaaa atttataaaa
     1621 ggcgaagatg tttctatgca tgaagttatg ttaataggtc aagaagcaca actatctatg
     1681 caatatttaa tagaagttag aaataagatt catgatgcat atcaagaaat gaataaggtg
     1741 caaatttagc cttttgaaca ggagtaataa tcaatgataa ccagttttaa aaataagatt
     1801 aaggagcaag ttgctaaatc taggacaaag ataagttctt taaaaaaggg aactaaaata
     1861 gcattaggta taggggttat tgctatatgt ttagcgctag tatttacagc aatatctgcg
     1921 agcaaaaata agtatgcagt cttattttca gaactagatg ctcaagatgc tgcagatata
     1981 tcagcagagc tagagtctaa aaagatagat actaaggtaa aaggaagtac gatttatgta
     2041 cctagaacag aagttgataa gttaaggctg gagttagcgc caagtcttac aggtggttct
     2101 aaaggatttg cactaatgga tgatagttca tcaatagggc ttactgatga agaatttcag
     2161 attaagaaac aaagaatgat acaaggtgaa atagaaaaaa caataaagag ttttccacaa
     2221 gtggaagaca ctagagtaca tataacattt ggagagtcat cagtatttga gaaggaggct
     2281 gttccaggga gtgcagcagt ttatttgatg ctaaaaccag ggacgacttt agaaaaaaac
     2341 caaataaagt ctgttatggc acttatatca ggaagcgtta caaatatacc agagaaaaat
     2401 gttcaggtta ttgataacaa aatgaattta ttatctgaag gtattttgga ggatgaaaat
     2461 gttgatgaaa ataatcaacc aataaatagt ggcattagtg ttgataaaaa taaggcatct
     2521 gaacaagcat tgaataaaca actagaaaag tctattttag aaatgctaga accgatattt
     2581 ggtaagggaa aggtgaaagc tacagtaaat gctgatttaa gttttgatac agctgaaaaa
     2641 actgagataa aaattgaccc tgataaagtt gcaataaagg agacaaggtc gaaaaattca
     2701 tctaaatctg ctgcaaataa tgttcaaggt gtagatgcta acatgaataa ccaaggaaat
     2761 aacaatggta ctaatacaga agatagttta gatgagagtt ttgagtatga aacaggtaag
     2821 attgaaactc acactatagt tgcgcctgga gaacttaata gattgacagc ttctgttgca
     2881 atagatggaa aaatagctaa aggtgttcaa gctgatgtag aggatattgt taataatgct
     2941 ataggtatgg atggagcgag gggagatact cttagcgttg tttcaatggt atttgaccca
     3001 gaaggtaaga aagaggctaa acaagagctg gaagagatta aaaaagaagg atttaaaaag
     3061 aacataataa aagcagttat tggagtagta gcagtaatag cagttggagc tattggatac
     3121 ttaatatata agaaaagaag tgaacgagaa gatatggatt atgaagatga agattatatt
     3181 tctaaatctg attctgttga taggaaggat aatcctctat taggagatga tccagaactg
     3241 acattagagg aagctgttaa aatgtatgca gaagaaaagc cagaccaagt aacagagata
     3301 ataaagactt ggttaaatga gtaaggggga tagaaagtgt ccacggaaat tacaaatgtt
     3361 aatgcgtttg acttaagtga tataaatgaa agtgataaga atgagaaggt agaaggtgag
     3421 ggtttaaaaa aagctgctgt attattaatg acattaggcc caaatgtgtc tagtgatata
     3481 ataaaaagct tgcctgataa acaagttcaa aaaataggtt tggaaattgc aaatatttct
     3541 tcaatagctt caaaagaaag aagagaaatc ttaaaagagt ttgtagaaat aaatagggca
     3601 aaagattatg ttatagaagg tgggcttgaa tatgcaagag agttattaag taatgcttta
     3661 ggaaatgtta aagcaaacaa attacttgaa ggtatatcaa taaatacaag tacaaagcct
     3721 tttaaacata ttataaaact agatgtaaag aagatattag aaatacttag gaatgaaagt
     3781 gcacaaacta tagccgtttt acttgcacat atggaaccag aaaatggagc agaagtttta
     3841 tcatacttag attttgattt acaaaatgaa gtagctatga gaataagctc aatgggttca
     3901 atatctccag aagtaataaa ggtaattgaa agttcattag aagataaatt acattcaata
     3961 agtggtgatg attttaatga ttatggaggg gtgtctacct tagttcaaat attgattaat
     4021 tctgatagaa aaacagaaaa gaatattttg ggaactattg aagaacaaaa cccggattta
     4081 gcagctcaaa ttaaatctca tatatttgtc tttgaagata ttgtcaagtt agatgatata
     4141 agcatacaaa aagtgttaaa agaagtgact atgaaagatt tagtatatgc cttaaaaggt
     4201 gtagatgatg agatttcaga tgctatatat agaaatcaat cttctagagc agcagatgca
     4261 cttaaagaag aaatggaaat ggttggtgtt ataaaggtta cacaagttga ggcttctcaa
     4321 caaaagatag ctaatatcgt aagaaaactt gaaagagaag gtgccataac tattgtaagg
     4381 aattttggtg gtgactttgt tgaataataa gattattaaa agtaaaaaag cattatataa
     4441 aggagtgcta gatttaacca taatagataa agttagagtg ggagaatcaa atgtaaataa
     4501 agaaaatgat tgtagattta gggatgaggt aataaaagaa gctatagaat ctgctgagat
     4561 aaaaaagaat gagatattag aagaagcaaa aataaatgca caaaatatag aaaagcaagc
     4621 atatgaaaaa gggtatagtc aaggtcaaaa aaatggatat gaggatggat ataaagagtc
     4681 atatgatgaa tatacccaaa aagctaaaga tgaagcagat tttataaaaa atcaggcaaa
     4741 tttaatctta ttacaagcta atgagaagat gactgagtac ataaaagaaa aaaataaaga
     4801 gattgtaaga cttgctatta atatggccag ttctgtttta aaaaagcatt tcgaagatga
     4861 agaatctatg agtgatctgt taaagcaaat tattcaagat tatgaaggaa gtagttcatt
     4921 tatagtaaga tgtaattctt tctataaaga taatatagag aaagagtttg aattattcaa
     4981 agaggaaaca tcactaaaat caagtgtatt tgttattgca gatgatagta tagataaagg
     5041 caatgctatt atccaaaagg aaaatggaag aataatagtt ggtattgatt gtgctatgga
     5101 aaaactaaaa gaagaattgc ttggtgaata aagtatgtat aaaactgata tatctataga
     5161 ttttgacaaa ataaataaga aaatagaaaa tttagaactc actatatcag aaggtagagt
     5221 aaagaagata ataggactta ctgtagaagt tgaaggaata aaagcttttg ttggggagtt
     5281 atgcgttata tacaaccaag ttaataaacc agtgaattgt gaagtagtag gttttaaaga
     5341 taaagaagtc atattaatgg cgttgggaga attaacattg atagcacctg gttgtaaagt
     5401 tatttctaag gggatacctt taagtgttat gtgtagtgat aatttactag gtaaagtact
     5461 tgatggtctt ggaaatccta tagacaactc agatgctgtt ttaggagata gatacaacct
     5521 gaacaatgaa cctcctgatc caatgaagag aaaaaagata cgaaatataa tggaaacagg
     5581 tgtaagagca atagatgcat ttactacttg tggtgaagga cagagaatcg gcatatttgc
     5641 aggaagtgga gtaggtaaga gtacgactct aggtatgatt gctaggaatg caaaagcaga
     5701 tgtaaatgta attgctctta ttggagaaag aggaagagaa gtactagatt ttattgataa
     5761 agatttaggt gaagagggaa tgaaaaaatc tgttgttgtg tgtgcaacat cagataaagc
     5821 ccctctagtt aggttaaaag gtgctcttac tgctactgca atagcagaat attttagaga
     5881 ccaaggcaaa aaagtaatac ttatgatgga ttcagtaact agatttgcta tggcacaaag
     5941 agaagttggt gtagcaatag gagagccacc agctcaaaaa ggatatacac catctgtatt
     6001 tgcaatgttg ccaaaactta tggagagaac agggacatca gataaaggtt ctataactgc
     6061 attttataca gtattagttg atggagatga ctttaatgag ccaatagcag atacaacaag
     6121 agggatactt gatggtcata tagttttatc tagagacttg gcaaataaga atcactatcc
     6181 ttctatagat gtattaaaca gtttaagtag gcttatgaat gaaattgctt caaaagaaga
     6241 cataaaaata gcgtcttttg caagagacat gcttgctgag tatagagaag cagaagattt
     6301 gataaatata ggtgcatatg cttcaggtac aaataaaaaa atagatgaag caatctatta
     6361 tcatgagcat attattaatt ttttaaaaca agggataaat gaaaagagtt cttttaatga
     6421 aactataagt agtttgagaa gagtttttga ataaacaatt aaaaaaatat ttgaataggt
     6481 tgtgatggaa ttggataaaa actttaagtt tagattacag aaagttttag acttaaaagt
     6541 gaaagatgaa gaagagataa aaatggaatt tgctaagatt caacaaaaaa aaatagatat
     6601 agagactaat ttagaaaact tagaaagtaa ttatagcaaa tattctataa gtaaaaataa
     6661 cgatagtatt caaaatcaaa aaataactat taactattta ctagctttaa acaattctat
     6721 aatggattta tcagaagagt tggataagtc aacaaatgaa cttgaaaaag ctagaaagca
     6781 gcttataagc aaacagatag agagaaaatc attagaaaaa ttaaaagaaa aaaagtatgg
     6841 acagtattat aaagaagaaa atttaaaaga acaaaacact aatgatgagt ttgcaagtat
     6901 gagttattta aggaatagac aagttctata agaatagtag gaagtgagga tattattgta
     6961 tgaagataca agcagattct tataatatta ttaaagatat tggggataga aaaagttcac
     7021 ctaagaacaa aaatataaaa aataataaat ttgaagataa tctatataag gcaacagacc
     7081 ataaaaaagt taaagataga agggaagtaa gtaagcaaaa tattagctca gataaaccgg
     7141 aaaatagtga taatgagtgt catttagatg aagataaaag taatcactta gaagatgaaa
     7201 atacatatga aaaagattgt agtaagaata atgaagcttt gcagcaatta ctgaatcttt
     7261 taaaggataa ttataaaaaa gataaagata taaacactat attgaataat atagaaaaac
     7321 taagtatatc agatgaatta aaacaagaac ttaagcttaa taaaaatata ttaaataaga
     7381 ttgcaaatca aaattcagag ctaaataaag ctaatataaa taactctaat gatatagaaa
     7441 atttagacat agttaaatta agagaacttt tggaagataa tgctaataaa gatattgaag
     7501 taattactaa aactacagaa aatgatacca aaaatataga tttgtatagt tttgatagca
     7561 atagaatgga taatcttaac tcaaataaac agaaagatga tagctctgat attttggaaa
     7621 aactagcagg ggtaaatgga aataagagtg ggaattttgg acaagtaata aataaaaatg
     7681 ttgatatgaa taaaattaaa aatgataatg tcaatttaaa acagatagaa tcaaatgtaa
     7741 tggatgactc tataaaagct attaagcata tgaaaacaaa tgatatacaa gaattgacaa
     7801 ttaaattaag accaaaagaa ttaggagata tgaatataca attgttaaaa gatggtgaaa
     7861 gtatgagagc tgttgtgact gttttcaata aagatgtctt tgactctata aataaaaaca
     7921 tagcagattt aaagcaacat cttgaactta ctaatgtaaa tataaaagat gtatcagtgc
     7981 aaatgcacag cgataataca aatacatctg atacctttga taaagcattt gaacaacaga
     8041 atagacaaaa taaccaagaa aacatgagta agaagaatac aaatgataag cataataatg
     8101 tagtcataga agatgacatt aaagaaaata ctattgatga tgatagagta gatttactag
     8161 cttagtaagg gggaagtatt gcatgtacgg aatagcaacg gctttggcag gaactaaggg
     8221 aaactatagg tcaaataact taagccaact tgaaagaaat attaatgata ttgccaataa
     8281 acaagttaga agcaaaggaa atcagacagt aacagacaat gggactccaa ttataggaca
     8341 aggtgatgat gctgataaag acttgtttat gaagatactt gtggcacaga tgggtaatca
     8401 agacccaatg aatccgcaag acccaacaga atatgtgtca caattagcac agtttgcaac
     8461 tttagaaaag atgtcagcta tgaatgagaa gctagatgta cttttagcct taagtaattc
     8521 cactctaata aactctgctt taagtatggc aacatcatta attggtaaag aagtagaagt
     8581 atctggggaa gagaaagaag atgaaaacat tgtaggagta gtaaagtcca catatataaa
     8641 agatggggaa gtacacttag aattagaagt agatggaagt gacaaaactg taggtgttaa
     8701 atatgaaaaa ttacttaaaa taggagaggt agatgaaaat tcaggagaag aaaatgattc
     8761 ttcagaacac gaatctccag aagaagcata atattaaatg agaaaagagg taaattcatg
     8821 ataaaagcaa tgtattcagg tgtaagtgga atgaaagcaa atcaaacaaa attagatgta
     8881 ataggtaaca atgtagccaa cgctggaact acttctttta agaaaagttc agctagaata
     8941 acagattcat tttatcaaac tgtactatat gcaagtgctc caacagctgc attaggagga
     9001 acaaacttag gacaagtagg tgtaggtagt aagatatcaa gtataaataa agatatggta
     9061 caaggaaatg tacaaccaac taatagacca tctgatttaa tgatagatgg agatggatat
     9121 cttccagtag taagacaagg aacagttatg tatacgagag atggttcttt taatttagat
     9181 acaggattta aagcagctga tggtgctttg aagaatatta aaggtggaag acttgtaaat
     9241 ggtgatggat atatgttaca aggtatgatt tatgatgggg aatataaagc tgatactgga
     9301 gaatttgtta aaaagggtga tgctaaagga aaagagccta ttgtaatacc acttcaaagt
     9361 ataagtccta aggatggaac agttcaaaat gtactagagt ataatatatc aaaggatgga
     9421 acagtagaat ttttattgag tgatggtcaa agaactcaat ttgtctatga tatacctgat
     9481 ggtgctaagg taggagatac acctgctgga atagataaat taaaaggtac aatacaaaaa
     9541 gtgcaaacat atgcattcca aaatccagca ggactagatg cagaaggagg aaacttgttt
     9601 aaaccatcag caaactcagg agacccacaa atagcaggag ctacaggaac aataatacaa
     9661 ggggcaatag aagcttccaa tgtagatata gcagaagaat ttacagaaat gataatagca
     9721 agtaggtctt tccaagcaaa cagtaaaata atatcgacat cagacgagat acttcaagaa
     9781 ataataaatc ttaagagata gtaggtacat attatgataa gagtaacgga tttaaacgga
     9841 agaaaataca tattaaattc agaccttata gtgaggattg attctgtacc agaaagtagg
     9901 attctcctta caacaggaga aaaaaacctt gtaaaagagt cggtagatga gatagtagat
     9961 aaagtaataa agtataaaag aaaaataaat gtaggttata ttaggagcga aaaataatga
    10021 aaaaaacaga ttcactgaca tttattggac taatagtatc tacagtatta gttttagttg
    10081 gtgccgcaaa aggaagtagt tcagggttaa agaatttttt tgatgtttca tcaatattaa
    10141 tcacagtgct tggttcattt ggagctctaa tgattacatt tactatagat gatataaaac
    10201 ttataaaaaa tgcattacaa tactcattta agacaatgag tgtatcaaag ttagatttac
    10261 tagaacaatt taaaacactt tctaaaaaag ctagaaaaga aggtctttta tcaatagaga
    10321 gtgatgtaat gggaatagaa gatccattta tgaagaaagg gttagagctg tgtattgatg
    10381 gattggaaat caatgagata aggtccatct tagaactaga gatagattct gttgaagata
    10441 caaataacag atactctaaa ctatttaaaa cttggggaac ctttgcacct gcttttggga
    10501 tgttgggaac actaataggt ttaatacaaa tgttagctga ccttacatct ccagatttaa
    10561 tagcatctgg catgggaaag gcattaatta caacgtttta tggttcttta cttgccaata
    10621 tcgctttgaa cccaattgca tataatatag atgagaagac tgaaaaagaa atttatgtaa
    10681 aggaaatgat gttggaaggt ataataagca tacaatctgg ggagagcagt atagtagttg
    10741 aggaacgttt agccacatac ctttcaaaca atgagaagtt agaaattatg aaatccaata
    10801 aaaatacaga aagagcaatg agcaatggcg cgtaaaaaaa ataagaaaaa ggatgagata
    10861 aatccagatg catggctggc tacttatgca gatactataa cactgattct tacatttttc
    10921 gtattattgt atgcaacatc agttgtagat atggaaaaat ttaaaaacat agcagatgcg
    10981 ttaaaaggtc agttttctgg gacaagtata tttagtacgg gttcaagtac aagtgagaaa
    11041 tctccaatag acagtgtttt agtggataaa aatgataaat caaatttaga acaggattta
    11101 aaagataaag ttaataattc taacttacaa aatagtgtaa cagtcaaaga tgatagtaga
    11161 gggattttac tagagttaga tgattcaatt ttatttgact ctgggatttc tgagttaaaa
    11221 gtagatagta aagctactct taataaagta tatgacatga taaagatgat gaaaaataag
    11281 atagttatag aaggccatac tgataatgta cctgtaaaat caagtacaca tgaatccaat
    11341 tgggatttat cttctagtag agcagtaagt gttgtaagat actttgtaga agaaaagggc
    11401 atggacccta gactattttc ggcaacagga tgtggagagt atcaaccttt ggtttcaaat
    11461 gaaacagcaa agggaagggc tgagaataga agagttaata tacttataac tattgactag
    11521 gaggaagagg tttgttcaaa aataaaaaaa ttattataat tattttgata ctgattattt
    11581 tctcagcggg agcaggtttt tttatattag gagaaggtgg aaataaacaa gttgacaaga
    11641 ttgcaggttt gtttattcca acaggaaaag gtaaagatga agtaaagacc gaaaatcttg
    11701 acttagaaga gatggtatta aagctagctg atgaaggtgt aagatattta aaagtatcaa
    11761 taactgtatc ttatgattct tcatataaag atatagaaaa aaatacgcct ttaattaggg
    11821 ataatattat aaattgtttt atggcaaaaa gggcagatga ttttactgct gataatttaa
    11881 agaacataaa agaagaaatt aaaaatacat taaatataca actaggtgaa aatgtaattc
    11941 aaaatatata tttcacaaat atagtagtgc aataaaagga tggtaagaca tgatacttta
    12001 tttactaaaa atattaatat gtatcccaat aattttaata ttgatagtct tatctttaaa
    12061 aattagccaa ggaactttat taaaaaaata taatgataaa tatgtaaaaa tactagatat
    12121 tgtaaatata agtaaaaaca atagcataat aattttaaaa ataggtgaag aaggatgcat
    12181 tatggcatct tcttcttcta gcatgagtaa aataaaagat ttgaccaaag aagaaatatt
    12241 aaaaatagaa aacgacatta aagaaagaaa ttttaaaatt caagatttta aaatggaaag
    12301 aattaaaaag aaatatgatt tcagtagata tattggaaaa tttacaaaaa aggaagataa
    12361 gtaaatggaa ctattatcaa aattaccttt ggctgatgta ccatatacaa gttcaatgca
    12421 attgttttta tttctaactg cattaatgtt tttaccattt gtaatgttca tgatgacaag
    12481 ctttgtcaga atagttataa gtttatcatt tttgaaatca gcattaggag cacagcaagc
    12541 aattccaagt caaattttgg taggacttgc aatagtattg acaatattta taatgagacc
    12601 agtattaaat gagataaacg aaaaggcatt acaaccatat atgaaagaag aagttactat
    12661 ggaagaagct atgaaggaag cagaaggacc tattaaagag tttttattaa cacaaaccag
    12721 acagacagat ttagatttat ttgtagaaca ggctggttta aaagaaaaga aattaactcg
    12781 tgaaaatata ccactatctg ttgtagttcc agcatttgct ataagcgaac taaaaactgc
    12841 ttttcaaata ggttttttaa tatatatacc atttttgata atagaccttg ttgtggcaag
    12901 tgttttgatg tctatgggta tgtttatgtt gcctccagtc atgatatcat taccatttaa
    12961 gttattatta tttgtaatgg tggatggatg gaacttgata gtaaaaacat tgatattggg
    13021 atttggatag gagaaaaata gtatgagtga atttatgata atgagtgttc ttaaaaatgg
    13081 catgtttaca ggagctatga ttgcagctcc agtactcatt gtttctcttg tagttgggct
    13141 tttaataagt gtgtttcaag ctacaactca aatccaggag caaactttga cttttgtacc
    13201 aaaactaata gctattcttt tagtagtagc tattggtgga agctggatgt tacatactct
    13261 tattagcttt acttctgaga tattcaatat gatatctctt ataactaaat aagtaggata
    13321 catatgattt ttgtatttat tagaatagta gcattctttg gaacactaag aatactattt
    13381 ccagctggta cacctgcttt atttaagtca ctctttgcaa tcattatatc aatattgatt
    13441 tcaagtacta tgcaaattga atatgcaaca aatatagaca acattgtatt gtttacctta
    13501 tatggtataa atgagaccat aactgggatt atgcttggat atataaccaa cctatgtttt
    13561 tatagtatca gaatggcggg ttctatgatg gaccaacaga tgggattatc aatgattaat
    13621 atgtttgacc caaattcaat gactcagaca actttaattg ataatcttat gaactggaca
    13681 gcacttatga tattttttag catggatggt catcatgttt taattagagg tataaggtat
    13741 agttttgagt taattccaat aggaaaacca tttgtagata ataacataga ttatataata
    13801 aacatatttg tgcagtgctt tttaactgga ttcaaaatag caatacctat tgtactttgt
    13861 ctgcttatgg cagattttat tttagggctt atatcaagaa gtgtacctca attaaatgta
    13921 atgatagttg gtatgccatt aaaaatattg gttggtattg cattatttat catatcaata
    13981 cctttaattg tcaatcaaat aagtcattta ttaagtcaaa taccaaagat gtatgaggga
    14041 acttttgcac tagctcctat gttttttatg ggttcaacag ataaaacaga agaagctact
    14101 ccaaagaaaa agggagaaca aagaaagaaa ggtaatatag caaagagtag agaattaccc
    14161 gttgcaatga ctctacttgc attcacctta ttagtaccta cattattttc atatgtagta
    14221 gatacactta aatcttcgct taattatttt ttgagtctag atttttatat gaacataaat
    14281 tattcaaacc tagagaaatt agttatagca ggattaatgg atttttttaa gatattttta
    14341 ccaatagcta ttcccttttt agttttaggc ataatagcaa acctatttca ggtgggaata
    14401 ctgtttactg gtgaaacttt aaaaccaaat ttatcaaaat taaatccagt tagtggattc
    14461 aaaaacatgt tttctatgag aagtttgtca accttaataa aggatatagc aattatatct
    14521 attttggctt atataggata tacattcttc caagataatt atttagatat attaaagcta
    14581 ggtaacatat acctaccaac tttaatgtac acagttaaag atttagtata ttcaatattg
    14641 agtaagattt gtgtagctat gatagctata gcagttgcag attatgttta tcaaagatac
    14701 agtcataaaa agcaactgag aatgacaaaa caagaagtta aagatgaata taaaaactca
    14761 gaaggagacc cagaagtaaa agctaagata aaacaaaaac aaagacaaat ttcgtctcaa
    14821 aggacaatgc aagcagtacc aagtgctact gtaatagtaa ccaatccaac ccacttatct
    14881 atagcagtga gatatgaaaa agggaaagac caagctccag tagtggtggc aaaaggtgca
    14941 gattatttag cttttaaaat aagggaaatt gcaaagggaa atgacatccc tataatagaa
    15001 aacaaaccta ttgctaggtt gttatataag caagtagaaa tagaccaaga aattccagag
    15061 gacatgtatc aagcttttgc agagatatta gtggcagtat ataaaatcaa aaatagatac
    15121 aaagtcccca aaaggtagga taagtaatga ataagtttaa tttaaaggaa aatatggacg
    15181 taatagtggc atttggtgtt gtagggattg ttcttatgat aatagtgcca ttacctacat
    15241 ttatattaga tattttactg gcaattaaca taagtttatc tgtgctaatt ttactaatga
    15301 cattatttac aacaaatgta cttgatttat ctatatttcc aacagtgtta cttgtgacaa
    15361 cactatttag attgggatta aatctttcat caactagatt gattttaaca cagggatatg
    15421 caggtgaagt tatagaggca tttggaagtt ttgttgtagg tggaaattac gtagtaggga
    15481 taattatatt cttaattata ttaattgttc aatttgttgt tataaccaat ggttctggaa
    15541 gagtatccga agtaacagct agatttacat tagatgctat gccaggtaag cagatgagta
    15601 tagatgcaga tttaaatgca ggagttatag atgacaaaac tgctagaaaa agaagaaaag
    15661 agcttcaaca agaagcagat ttttatggtt ctatggatgg agcaaataag tttgtaaagg
    15721 gagatgccat agcaggtctt atagtaacgg caataaacat aataggtgga attgtaatag
    15781 gagctgtaat gctgaatatg actcttatgg gtgcagcaca gacatatgta agacttactg
    15841 taggagatgg tcttgtaagt cagatacctg ctctattaat atctacatca gcaggtataa
    15901 tcgtaacaag agcttctact gatgaaaact ttggtggatt agtaggtaaa cagttaacag
    15961 caataccaaa agcagtaatg atgactggct gtgttctaat cgtacttggt atgatgcctg
    16021 gattacctaa accagcattt ttttcactag gtataggtgc tatagcagca ggttactttt
    16081 taggaagaga aaagaaagat actttagaag acttggagtt tgaaaaacct gatatggtaa
    16141 atccagataa aaatgaagta gaagatgtaa caaacttaat aaatgtagaa tcaatagaag
    16201 tagaaattgg atatggttta atatctttag ctgatgaatc agcaggagga gatttacttc
    16261 agagaatagc atcaataaga agacaatgtg caatagacat gggtatagtc gtacaaccta
    16321 taagaataag agataattta cagttaaatc caaaccaata caatataaaa ataaaaggga
    16381 atgtagttgg tgggtatgag ataatgccta atatggtttt atgtatggat cctatgaatc
    16441 aaggatttag tatatttgga ataaagacaa ttgagcctac ttttggaata gaggcacttt
    16501 ggatagaaag tgacaaggta gaagatgcag agttaaaggg ttatacagtt gtagattcat
    16561 ccacaatact tataactcac ttactagata taataaaatc aaatgcacac gaattactgg
    16621 gaagacaaga agttaagact attatagatg cagcaagaga aaattatagt gctgtagtag
    16681 atgaattgat accagatttg atgacacttg gtgaaattca aaaagtactt aaaaatctgt
    16741 taagagaaaa agtaaatata aaggatagag ttacaatact tgaaacgctt gcagaccagt
    16801 ctagaaatac aaaagatata gagcttctta ctgaatatgt aagaatagcc ttggctagaa
    16861 gtatttgtaa taatttagtt gatgatgata agacaattgt agtggctaca ttgtctccag
    16921 aaactgaaga gttgatatct aataatttac agaggtctgt aaatggaact tatccagcag
    16981 ttgacccaga aaatacaaat aaaatatttg aaagtataca agaagtaatg agcaatgtat
    17041 atttcaatca taatatacca gtaatagtag tatcaccaaa gataagagct ccatttagaa
    17101 aattagttga aattgtatat cctaatttga ctgtattatc attaaatgaa atacctaacg
    17161 atattaaaat caaagcagaa ggtgtggtga gcatatatga tgacgaaaaa gtatacagct
    17221 aacacaattc aggatgctat gaatctagcc aaaatggaat tgggtgacaa tattacatta
    17281 atagataaaa aagaagtaag aaagtctgga atacaaggta tcttttcaaa gaaagatatt
    17341 gaactaacta ttggatggga aaagagagaa aacatagaac aaaaagattt aaaacgagag
    17401 atagaacaat taaagttaat tattaacaat atggggtttg ataataagaa tgataatgat
    17461 atagataaaa tatgtaaaaa tctactaagt ttagaattga atgaagaaat tgtagaatct
    17521 ataagaattg atttgcaaga aatgaagttc aatggaatcg atacaagtaa aaatttagta
    17581 gaaattttaa agaaaaagat taaaatagaa aatcaagtaa taaatggtaa aattgctcta
    17641 gtcggaccac caggagtagg taaaacgact acaatagcaa agttagccgc aaaattagtt
    17701 tttgaagaaa ataaaaaagt aggagtaata actatagata catacaggat tggtgctgta
    17761 gaacagttga agatatatac tgatataatg aatattccct ttaaaggggt aataagtcct
    17821 gatgaaatgg aattggcact tgacgagatg aaagattgtg atgttgtatt aatagataca
    17881 acaggtagag gctataaaaa ctctatgcaa atactagaaa tcaaaaatct tatagataaa
    17941 gctgaaactg ataatataca tttagttttg aattgtacaa caagagaaag tgatacaaaa
    18001 gcaattatag attcatatag aaatgtgaat tttaaaagct taataattac aaagctagat
    18061 gaaacaataa catatggatc aatatttaac ataatgaatt atgcacaaaa accaatatca
    18121 tatattacaa caggacaaaa tgttcctgat gatattataa aacctaatga agataagatt
    18181 ataaggttac tattaggagt tgaaagtata tgatagacca agctcaaatt ttgagaaaaa
    18241 tggcaatgga aaaaagagga cttgatgagt ttatagtaga gaatgagaat gtacctaaga
    18301 taattacaat agcttctggt aaaggcggtg ttggaaagag caatctcgct acaaatttgt
    18361 ctatatgcct gaccaaactt aataaaaaag ttcttatatt agatgcagac ataggaatgt
    18421 ctaatataga tataataatg ggggtaaatg taaaagggac tataattgat gtaattaatg
    18481 gcgaaaaaaa tatagaagat ataatttcac agactaagta tggtgtaaat ataatatctg
    18541 gaggttctgc ccttaatcat atagaagact ttacagaagc tcaaagaaat aagtttatac
    18601 atagcataga acagattcac gatgtggatt ttataataat tgatacagga gctggtatga
    18661 gcaaaagctt attgtcattt atatactgta gtactgaatt tttcttaata acaactccag
    18721 aaccgacatc attgactgac gcatatagtt tgttaaaagc tataagtaat tttggcataa
    18781 agagaagtgc aaatataata atcaataggg taattgattt agaagaagca aaatctacat
    18841 acaaaagaat aaaaatggtt gtggacaaat ttctaaacct taatctagaa ttgtatggat
    18901 atataataga tgacaaaaaa gtaagtttat gtgtaaaaaa acagatacca ttcattttag
    18961 aatatcctac aagtattgca tcaaaatgta ttatagccat agcaaagaga atggtaagtc
    19021 agtcaagaga agatattgtt gataataaaa gttttctaag aaagatgttt agtatattta
    19081 aaagctaagg aggcgtagtt aatgaataga gaagaattaa taaaagagaa tatgcctctt
    19141 gtaaagagta tagcaagaaa attttttata ccagggaaag gttttgaata tcaagactta
    19201 gtaaatagtg gagtcattgg attgattgat gcaataaata aatttgatgc tgaaaaaggg
    19261 gcaaagtttt ctagttactc ttatataaaa ataaaatctg ctatattaga tgaaattaga
    19321 aatcaaagtc caatttctaa acataatcta actaaagtaa ataagtataa tagagtggta
    19381 gaaaagttgc aatctaaatt attaagagag ccaacttcat atgaaattgc aaaagaatta
    19441 aaggtttcag aaaaagaact tcatgatatc gaaagtaata tagatatgtt aaatattgta
    19501 tcattaaact atgtaatctt tgaagataca aatgaaactg tacaagatgt aataagtgat
    19561 agagaagagg aagctccaga aaatataata gaagaagaag aaaagttaga gattctatcc
    19621 aaagcaatta gtaatttaaa tgaaagagaa aaattaatac tttcactgta ctattatgaa
    19681 gatttaaatc taaaggagat agggaaagtg ctaggtgttt cagaatcaag agtttcacaa
    19741 ctccacagaa aatcaataag aaacttaaga aacaagataa aagaacttaa atattctata
    19801 tagatggtga ttgataagat gatacaaatt atattaatag tagtgtctat tttaataata
    19861 gtaactatag ttataaattt acataaggaa tcaaaaaata aagataacag atactttgat
    19921 aaaatatttg agcaagaata tgaagcaaat gatagattaa taattgcaga aaaaagaaga
    19981 ttctttttag acaaagtact tgcagaaaaa agaattaata gtcatataaa agtttatgaa
    20041 aattataacc taataaaggc taatgaagaa agaaaggaaa acatatttat agaatcaaaa
    20101 aaggaagtaa gacaagaaaa tgagttatct cttaaagtga aacatcttat aagttcaggt
    20161 tatgatgatg tggaaatatg taagatgcta gatattggaa agggggaact gttattaata
    20221 aggagttgtt acaaaatata aggatattat tatgtgataa aaaagtattc ttaggaatag
    20281 gtattggtat attaatatca actttatgta taatgctttt tagtaataat gatatgagta
    20341 aggcagagat agaaaaaaag gccagagcgt taggcatgaa atatacaagt gagatgaaag
    20401 ttttagaata gatgatattg tttagacatt tacaaaaaag gaggtcataa tgtgataaga
    20461 ggattatata cagcagtttc tgctatgata actaatcaac aaaagcaaaa tgttgttgtc
    20521 aataacctag ctaatatgga tacaaatgga tataaaagta aacaactttt gactaaaagt
    20581 tttgatgaat taaagttgga gggttacaat aactacgcaa atggaactaa acaaaagcag
    20641 attataggcg atataagtcc aggtatttct atggatgaaa ctatcacaaa ttttaatcaa
    20701 ggacctataa aaactactga taataaaatg gatgtagcta ttcaaggtaa gggatttttt
    20761 ctagttagtg atgcagctgg aaatcaattt tacactagaa atgggaactt cagaacagac
    20821 aatcaaggtg accttataac aagtgaaggg tattatgtac ttgggacgaa tactgctact
    20881 ggtgctgtag gtcatataaa tgtaggaaat caaaaatttg aagtggcaaa agataataca
    20941 atatcactag acggaaatgc tatgtataaa tttaatattg tagattttaa taactacaat
    21001 aacttaaaaa aagaaggaga taacttatat tctggaggag gagctatgaa agtaaataat
    21061 gcacttacaa tacaaagtgc gatagagtcc tctaatgtag atatggtatc tgaaattaat
    21121 aatatgatga caatatcaag agaatatgag gcaaatcaaa agataattca ggctatggat
    21181 tctaaattag caaaaatagc aagtgagatt ggttcagtaa gataggtaat aggaggtgaa
    21241 tttttatgta cacaatgttt tatactagta aaacagcttt atcagcaaat caaagtaaac
    21301 tagatataat atctaacaat atagcaaatt ctgattcaac aggatataaa aaaataaata
    21361 tggaatattc tgatttagtg gatgaagtac taaatagacc atcatatcct acaaatggca
    21421 atgatatatc gactggaaca ggagctaagg caacagctcc catgagaaat tatgaacaag
    21481 gtgcattggc tcctacagat agtaagagta atttggcaat agatggagaa ggattcttta
    21541 gagtgataag aaaagatggt acatatgcat atacaagaaa tggtggattt aatgtagatg
    21601 ctttaggtaa gattgtagat gataatggaa atatattaga tgtccaattt gatgcaggat
    21661 ataactataa taatacaaat atagatagta caaacctgac agtttcaaga aatggagagc
    21721 tattcgtaga taataaaaaa ataggaaaaa tcaacttata tcaacctata ggaactcaaa
    21781 attttatatc tgaaggagat agtttattcg tcgcaactga tgcagcacag attaaacaag
    21841 ttgagaaagt cgatatagtt caaggctata gagagaggtc aaatgtttct ttacaagaag
    21901 aatttgttga cttaatagcc actcaaagag catttcaaat gaactcaaag ggaataaaga
    21961 cagcagatga aatgtggcaa atagcgaata atttaagagc taaataatta tgtaaggtga
    22021 ggaatattca tgaatgatat gaaagagtac gattttggca aacctcagag ttattcaaga
    22081 gaaaatttaa cttgtttaaa ttttttatta gctgaatttt gtaaaaaata taaaaactat
    22141 ataatttatg aacttaagtg taattctagt atggttgttg atagtataga ccaagtaaat
    22201 tatcagactt ttttagatag agtaacttct tcatgcgtag tagtacaaaa tgcaatggaa
    22261 cctgttatga aaaacttttc ttttagaata gatagaagtg tagctgatat gtggattgat
    22321 ataacttctg gaggaactgg agttgtaaag gataatgata gagaacttac agaacttgat
    22381 aaaaaagtgc ttttacacct tatggatgat ttagtaagaa atatgcactt atttgagggt
    22441 tttgaaaata tacaagtatt ggatacacat acacatatta atttgccaca attatgttct
    22501 ccaactgcac cagtatgcgt tgtagattta aaagtgctaa atgataatga gtatattgga
    22561 agtgtttctc tttgctttcc atacaatggt ttagaggctc tgttagaaag tatatctgtt
    22621 atagaatttt ttgataatga tgtaggagat gattcagagg aatttaccca aaaaatctat
    22681 aatagtgtat ctaatataga attatcagtt attgcagaga taggaaaagt atcaattaat
    22741 gttgaggatt tactcaaact agaagttgga gatgtaatag taacaaataa aaaaataaat
    22801 gattatatag atatatttgt agaaaattca aaatcataca cagcaacacc aggatttata
    22861 tcaagtaaaa aaggtgtaaa aataaatgat gctgttggaa aagaggtgta gttatggaca
    22921 atagtaatct tatttcagat gaagaagcaa agatgttatt aaatgataaa gttgaaagtg
    22981 aagttgatgg agatgatgag ttagccttag atgtctctga agttaatcga aataatatac
    23041 aaaggatact tgaccttaag ttagaattat ctgtagttat aggaagaact aagatgactc
    23101 taagagatat tttaaattta cataaaggtt ctcttattga actggatact ttggcagacc
    23161 aagatgtgga aatactaata gataataagg ttttggctta tggaaaagta gtggtggtag
    23221 atttaaattt tggtgtaaag ataacaagta tagtaagtga agaagacatg gtaaaatctc
    23281 ttgtttagag ataacatcaa ttaatactta aggcatgagg tggtacttat tttaaactta
    23341 aatgatataa aaaaagatat actaaaactc aataaaaaag actcatgttc tctatataat
    23401 gaatctatta ataatataaa taataattgt atatcaactg gattaaaatt tttaaaacaa
    23461 gcaagagatt taaacccaga tgatgttgat atattaaatc tcacaggtct tgtaaactta
    23521 ctaaaatgta attttgatga tgctgtagaa agtttctata agagttcact ttgtgaaaaa
    23581 actgctctgt gtgaaaagta tataaacatg cttacatctg aggagttttt aattttcttt
    23641 gaaaagtaca atcaacttat aaggttaata aataaaggaa tgtataaaga agctatacaa
    23701 gggtttaaac ttataactga ccaatactgt gatttaatag aaccttatga gttgcttgcc
    23761 ttactgtatg acaaggaaga agaatatata aaatttgatg aatgtttaga agtattgaag
    23821 attattgata aggaaaatta tttattaaat caagaaaata acacattata tatgtataat
    23881 agtgctaata tacaaactaa aagtaatata aaagtagatg attataagaa tgagttctta
    23941 cataaaagta gtagtaacca taaaattaat gattataatg atgtaactaa agaaaagagt
    24001 tcaagcaaaa accagaaaag ttcagattct aataagaaaa aaagtattaa aaaaaataag
    24061 tacctatata tagccataat attaggaata ttattagtag gacaaagtat atatagttct
    24121 tataagatga ataatttaac tgataaaata tctaaaaata atgaaactaa aaatgaagag
    24181 tcaatagatt ctaacttgac taagaaagaa aataatatag aagaaaatga agatatgagt
    24241 aaggcttcta atataaataa gagtaataaa aacattaata aagaggatga tgtaaaatct
    24301 aaaaaaaata ctgtagaaaa tgaagatgat aaagattctg acttatttac agaggatgaa
    24361 ttgatgtcta aggcgaatac tttaaaatca gaaaagaaaa ctaaatcttc tatacaacta
    24421 tataagaaag ttgcagatat aggtgaaaat aaagggaata catctgaagc aacttatcaa
    24481 gttgctattc tcagtgaaaa gttaaaagac tataaaactg ctgaagaata ttataaaatg
    24541 tatgtagaaa attactcaga aaaagatgct tattttgatg aatcttatta taatttaggt
    24601 atgatgtact ataacaatgg tgatttaaaa aattctaaat tgacattaaa gaagttggtt
    24661 aataaggtac caaatagtat gtataataat tcaaaagtaa aagaaatttt aaaagaagaa
    24721 tagttaaatt agataagaaa aataaattat tttattttaa aataatatga ttataatata
    24781 ttgacatacc attttaaaaa atttaaaata ttaattataa aatgaggagg gataaaaaat
    24841 ggaatttgaa aaagggagta tttcaattca tacagaaaat atttttccta taattaaaaa
    24901 atggttatac tctgacaaag acatatttat aagagagctt ataagtaatg gatgtgatgc
    24961 agtaagtaaa cataaaagac ttgtatcact aggagaaata tcagaaaata agtcatcaga
    25021 ttataaaatt acagtatctg taaataaagg agaaggtaca cttaaattta ttgacaatgg
    25081 aattggtatg actgaagaag agataaaaaa atacataaat caagttgctt tttcaggtgc
    25141 tgaagatttc tttaataaat ataaggataa aatggaagag tcaaatgata taataggtca
    25201 ttttggacta ggattttatt ctgcatttat ggtgtctaaa aaggtacaaa tagatacact
    25261 ttcatataca gaaggagcga ctcctgtaag atggatatct gaaggtggta cagaatacga
    25321 aatatctgaa tcagatgcta gaaatgatag aggaactact ataacactat ttattgatga
    25381 tgatagtaaa gaatttttag atgaatttac tgtaagagga ataataaata aatactgttc
    25441 tttcttacca gtagaaatat atttagaaga tgttgaaaga ttagaaagag aagctaaaga
    25501 agcagaagaa aaagctaaaa aacaaaagga agatggaaaa gaagagattg tagatgcaaa
    25561 agtaattgag cctttaaacg acactaatcc tctatggtta aaatctccaa aagactgtac
    25621 tgatgaggag tataaagagt tttatagaaa ggtattcaat gtatttgatg aacctttatt
    25681 ttggatacat ttaaatgtag attatccttt caatttaaag ggtatacttt acttccctaa
    25741 attaaaaaat gagtttgaac tgactgaagg aaaagtaaaa ttatacaaca atcaagtgtt
    25801 tgtggctgac aatataaaag aagttatacc agaattttta cttttattaa aaggagttat
    25861 agactgccca gacttaccat taaatgtatc aagaagtttc ttacaaaatg acagggatgt
    25921 aagcaaaatt tctaaacata taattaaaaa agtagctgat aagttgaaat ctctttgtaa
    25981 aaatgaaaga gaagaataca ataagttttg ggatgatata caaatattta ttaaatatgg
    26041 ttgcttaaaa gatgaaagtt tctatgagaa ggtaaaagaa tgtatattat tcaaaactat
    26101 tgatgatgag tatataacat tacaagatta tttagaaaaa tgtaaggaca aacatgaaaa
    26161 taaggtattt tatgtaagtg ataaggaaca gcaatctcaa tacattaaac tatttaaaga
    26221 atacgactta agtgctgttg ttttaaactc atcaatagat actcatttta tttcatttat
    26281 ggaatataaa gagaatggag ttaagtttaa tagaatagat gcagaccttt ctgatgtatt
    26341 aaaagataaa aatgaaaata aagatagtga agaaaacaaa gaagagatag ctaagataga
    26401 aggtttgttt aaagaagctg tcggagaaag agtgaagaat tattctgtag aaggattgaa
    26461 aaatgaagac actccagcta tggtattagt atcagaacaa tctattagaa tggcagaaat
    26521 gcagtcaaga tttgctggaa tggatttagg aatgaatttt gaggaagaaa aaactcttgt
    26581 aataaatgag aacagtccaa taatcaaaaa attggtttct cttaaagatg atgaggaaaa
    26641 gaaagataag attacgctta tttgtaacca gatagcagat ttagctttac tttctaataa
    26701 agaattaaag ccagatgagt tagattcatt tgtacaaaga agtaataagc ttatgagtct
    26761 tttgatagaa ttgtaagatt gaatttgaat acattgaagc aaatttataa aaagtattca
    26821 atatcagtga tgagaaagaa gtgtctcaaa atgaactttt cagttcatga ggcgcttttt
    26881 ttatgtgaaa ttaaatttat tttaatcatt tcaacaatga aaaatatatt tatctctatt
    26941 ttgagacaga ccgttcttta tttttttatc tttggttaat ttttaaatat ttaagtaggt
    27001 tctaataaaa aactctattt agttaaatat agttaacttg atatataata agataataca
    27061 tataattaag taaaagattg ttttttagtt tatgtttaaa tacataatta cactttgtta
    27121 aaaacataaa attattacta aagtagaaat aggaggtttt agcatgaatt ttaattataa
    27181 tttgccagta aatatcttat ttgggagagg cagaattaat gatgtgggaa aagaagtatc
    27241 taaatatggc aaaaaagtat tgatagtaac aggtaaaaat agtacaaaga aaactggatt
    27301 acttgataaa acaatagatt tactaaaaga ctctaaaata gaatatgaag tttttgatag
    27361 agtagaacaa aatcctctta taactactat atattcagga gtagaaatta taaaatcaac
    27421 tggatgtgat tgtgttttag gtcttggtgg tggaagcatt atggatgctg ccaagagtat
    27481 agctttttct tataaaaacc caggagattt aaatgattat atatttggaa ttagacaagg
    27541 tgaagaagct ttacctataa tcttagttcc aacaacatca ggtacaggta gtgaaggaaa
    27601 ttgttttgca gtacttacaa attcagaaac taaagataaa aaatctataa agaagaatag
    27661 tatgtatgca aaagcatcaa taattgaccc agaacttatg gttacaatgc caaaacatat
    27721 aattgcatca gttggatttg atgcacttgc ccataatatg gaagcatatc tttctaatgg
    27781 aagaaaccct cttgcagatg tacaagctat ttatgggatt gaacttatat cagaaaacct
    27841 aataaaggta tataatgatg ttaatgattt agaagcatgg gaaaaaataa cacttgcaag
    27901 tactattgga ggaatgacga ttggtacagc gggtacagcc ttgccacatg gaatggagca
    27961 tcctgtaagt ggtcttagag atgtaatgca tggaaaagga cttgcagctt tgactcctac
    28021 tattatagaa agttcatggg atagtgatat tgaaagattt ggtaatattt caaaggtatt
    28081 aggaggaact tgtgcagaag attgttcaga tgcaattaga aatttcctta aaaaaataga
    28141 tttagatata aaactaagtg atttaggtat tgaaaaatca gatatagatt ggttaactga
    28201 taattgtatg aaaatatcag ttgcaaatat taagagacat ccaaagtatt ttaataagga
    28261 acaaataaag gaaatgtacc ataagtcttt ataatttgac tttacatatt tagttttata
    28321 taaaaattat aaattaataa taaaaaatta taagtaatta atagtaaaaa aattgtgtat
    28381 agaagttata tatataataa atttgtctta agcttttatt ttactttcta ataaataaag
    28441 gagtttaaaa aagggaagat taattaagta atattttata aaattcttcg atttaaaaac
    28501 tttaagtaga ggtgaaataa atgtttaatc ccaaaagaat aatattcgaa aaaggaactt
    28561 tagacactga tgtgggtaaa aaaatataca ataaatttag agataataaa gatgtagaga
    28621 taattaatat atcatcaaat aggattaaag aacatattcc aggtgaaaat ctatatgaac
    28681 aatatagaag tgggaagcag actatggtag ttgggattag aaaaagtctg aagtttcaaa
    28741 catgtaaacc ttctgctaat tatcaactac cacttgtcag tggatgtatg ggaagatgtg
    28801 agtattgtta tttgaacaca caattaggtg ataaaccatt tataagggtg tttgtaaatg
    28861 tagatgaaat acttgaacag acaaaaaaat atattgaaga tagaaagcca caggtaacca
    28921 tatttgaagg ggcagctaca tcagacccag ttccagtaga gccatatact aattctttaa
    28981 agaaaacaat agagtttttt ggaagagagg aaaaaggaag atttagattt gttactaaat
    29041 acagtgatgt ggatagctta ttggatgctg aacataataa tcatacagaa atacgattta
    29101 gtatcaatac tcctagaatt ataaatgaac atgagcatta tacagcctct gcaaataaaa
    29161 gaatagagtc agctgtaaaa cttgctaggg ctggttatca gattggtttc ataatagcac
    29221 ctgtgttttt atatgaaggt tggaaagaag agtataaaaa tctgattata agtataaaag
    29281 aagctttacc aaaggatttt gataaaaaaa ttatatttga agttatatct catagatata
    29341 caactaaagc aaaaaataga atactagaga tttatccaga tacactattg ccaatggaaa
    29401 atgaggatag aaagtttaaa tacggtcaat ttggatatgg taagtacgtg tatgataaag
    29461 aacaattaga tgatatgaaa gagttctttc ttaaggaaat aaatggagta tttaaaaata
    29521 gtttaataaa atatataata tagcaaatct tacctaaaga tttgctatat tttattttta
    29581 tacattttat gtttataata aagcaatgag atttagcact atcatataag aaaattaaaa
    29641 agggcactat ctatcaagaa cattttttct agttttgata ctataaagga taagagtaac
    29701 aaaaatatca ggaggagtta tagtatgcat gcatgggagt ctattcaaat tacattggat
    29761 ttaatagaag caaatttatc agaagaaata tcaattaatg aattagcaaa taaagcaaat
    29821 ttatcaccat tttactatca aagactattt aaaagattgg taaataagac tgtaatggag
    29881 tatataaagc ttcgtcgtct tgcaagagct tctgaatact tagcagaaca taagaatcgt
    29941 atacttgatg tagctttaaa ttttggattt gctagtcatg agacatttac acgttccttt
    30001 aaaaaagcat atggattaac tccagaaaaa tatagagcaa atccagtaaa actcaatcac
    30061 tttattaagc cagaattaat tttaaattat gctatggttg atgaaggtgt tccactgatt
    30121 gcagatgata tagtgattga agtcaatcgt aagacattga gtaatccaag gacatttgtt
    30181 ggaatagaaa tagaagtacc tatttgccag ttggtgggcg gtgaaacaac tggaattgca
    30241 atagtagagg aattatggat gaaacttgga agtcaaagac ataatatacc aaatcaaatt
    30301 ccaggtggaa atgaatttgc tgctctttat atgggaaatg caaaagaagg aaattgtatg
    30361 tatatggcag gtgtagaggt agagtcaggt acatcagtag aaggatatag tacttttgag
    30421 ttgccagcta aagaatattt agtatgtgga tttgaggcag aaaactttaa tgagttagtt
    30481 aattcagctg tttttaaagc agataaattt atggaaagat ggatgaagaa acataattta
    30541 acaactactg attttgcaat tgagatgtat taccccacta cacctgaagc agcatatctg
    30601 gaacattgga ttgttccggt tcctattgaa caatagaaag gatgatgaat atgaattggc
    30661 aagatgcgtt ttttcaagat actaaaccta aatttgagca aattaatgaa tttattaata
    30721 atccattatg ggacaagtta aataaaactt tggtttctac ttataatgta gaacctaagc
    30781 ttgaatacag taaatgttca atgcaaagag gttggaatgt aaaatataaa aaaagaggta
    30841 aatcactatg tactttatat ccacaagaag gttattttaa agctttggtt attgtaagtg
    30901 aaagcaatag agtagaggtt gatttattta ttaatacttg ttgtgattat atcaaaaaaa
    30961 tatataatga ggtaaacttt tttaatggaa gtaaatggct aatgattcaa gtagatagtt
    31021 tattggtatt aaacgatatg cttgaactaa ttaaatttag agcttaacat atagaacagg
    31081 atgaatatat aagtcatcct gtttttatat tcaatcagat aaattaatat atagtctata
    31141 atatgaataa tttagtaaat ttaaatttac tttatctttc tacattcttt gcaactaagt
    31201 ccacatgtgt ttttttcttg catattagta gcaccccaat tagcaaattg ttgtaaaata
    31261 ggcacaatac ttttaccttt acttgttaat gtatattcaa cttttggagg aatttcatta
    31321 tattgtttac gatgaacaat accagtagac tctaaatctt ttaatgattg agctagcata
    31381 gtatttgtaa tgccatccaa ttttcttttt atgctactat atctaattgg attttcaact
    31441 gctaacatac atataatagg taatttccac ttaccaccga caatgtctaa tgcataacgg
    31501 attggacagg ttaattcttc aacgttttta gttatatttt tttcagtatt tatactcatt
    31561 ttaattactc cttagttata gtagtatctt ttttatactt tatcagaaaa aactgcatac
    31621 ttgttttttc tgtattttat attaaaatta tatcaaagga taatccttaa tacaagtatt
    31681 taaaaggggt gtaagaatta tgaaagcatt agaatttttg aacaaggcac gagtttatta
    31741 tttagcaaca gttgatgaga acaatcaagc acatgtgcgt cctttaggat ttgttatgga
    31801 atacaatggt aaacttacat tttgcacatc taatcaaaag gatatgttta agcaacttat
    31861 ttttaatcca aaggttgaac tttgttgtat agaccaaaac cttaatactc tacgtatttt
    31921 aggtgaagca gtatttgtta catcaaaaga aacacaagct aaggcacttg aaataatgcc
    31981 aagtttaggt cagatgtact ctgtaggaga tggtaagttt gaaatattct ctattgataa
    32041 ggcaaaagtt agttgttgtt caatgagtgg taaaaagatt gatgtagagc tttaattata
    32101 attgaatcga catccatagt gaaaattaag aaaacgttat tactgaaatg ttgatagatt
    32161 taatttaaat gcaataaaaa gatttttaaa taatgaatat gtaaaaattt ttagttatta
    32221 gatgtgtatt tcaataatga tatactattt tgaataatta catactagaa ataagataat
    32281 taaaatttac tttataatgg gatagatttc ttttaaaaaa tattttaact ataattgatt
    32341 tttatttaat ctgaaaaaaa tattatgact ataaaaaatt gctact
//
LOCUS       DAEQCW010000038        32096 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.038, whole genome shotgun sequence.
ACCESSION   DAEQCW010000038 DAEQCW010000000
VERSION     DAEQCW010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 32096)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32096)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32096
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.038"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            150..884
                     /locus_tag="KRO40_001767"
     CDS             150..884
                     /locus_tag="KRO40_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2092588.1"
                     /translation="MKIVNKSSNIPLHTQLSSIIREMIETGELKEGDAIMPERELCNI
                     QNVSRMTVNKTIVGLVTEGLLYRVQGKGTFVAKQKKKYQFSNVKGFTDVMKEKGVNIK
                     TDILSFEMELPDDLVKRKLGISDNTTNIYKIVRLRYTDGEPFGLEIVYLSEEMCKGLT
                     KGILDNSSLYRVLNEKYGYKIQKAEQVMEPVILSDEESKLLETDEGALALKLHRNSYN
                     REGSPIEYTISIFRTDKYQYEIVLSE"
     gene            894..2027
                     /gene="nagA"
                     /locus_tag="KRO40_001768"
     CDS             894..2027
                     /gene="nagA"
                     /locus_tag="KRO40_001768"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBH2092589.1"
                     /translation="MKCLINGKIILKNQILENKVLVFDEKIIDIADSVPKDCEVIDAD
                     GKYISPGLIDIHIHGNMGKDTMDSTDESIETISKSIMRHGVTSFLPTTMTMDKEHVYD
                     ALEVIKKAQNRKLEGAQVLGAHLEGPFINENYKGAQNEKFIINSKYEFIKEYKDVIKV
                     ITYAPEKDIDFDFTREIKRCTDIVLSIGHSNANYDQAKEAINLGVTNVTHMFNAMTGL
                     NHRDPGVVGAALTTNVYSELIADTIHINKDLFQFILNNKGKERLILITDSIEAGGLED
                     GNYSLGGQKVIVKGNEARLENGALAGSVLSLNKMVFNFLDNTNLKVNEAINLASLNPA
                     TSLGINDKKGSLEIGKDADIAVFDENLDCKMTLCLGDVVYKNI"
     gene            2126..2875
                     /gene="nagB"
                     /locus_tag="KRO40_001769"
     CDS             2126..2875
                     /gene="nagB"
                     /locus_tag="KRO40_001769"
                     /EC_number="3.5.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012425552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HBH2092590.1"
                     /translation="MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMY
                     RDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSYDYFMKENLFNHVNIKPENTHLP
                     NGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
                     TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEV
                     PGSILQLHKDTIVIVDEAAASKLNPKDYKLV"
     gene            3050..3322
                     /locus_tag="KRO40_001770"
     CDS             3050..3322
                     /locus_tag="KRO40_001770"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092591.1"
                     /translation="MLKIIMFSGILSSIIKLPIIGILPTGNIKKNTGISDSKKDGKQR
                     RSNLGISIYQLPSFLYSLINNSVPSNKPIPPEEIKLIKMYLLKSCI"
     gene            3982..4686
                     /locus_tag="KRO40_001771"
     CDS             3982..4686
                     /locus_tag="KRO40_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092592.1"
                     /translation="MSKLIYIADDEDNIRNLVKTFLKNEGHDVMDFKTGDELLEQFNI
                     KECDLVILDIMMPGSSGFEVCTKLREKSTVPIIMLTARDTDIDYITGITLGSDDYFTK
                     PFSPMSLVMRVKSIFRRIEFEKKQNYDKYSNSIDMELKFGDVIINKKNKIVTSKNVNI
                     DLTPNEYNLLTYLFENIDRAVSRDELLNKIWGYDIEVETRAADDTVKRLRKKILNTNI
                     LIETVWGFGFRLKEKS"
     gene            4688..6175
                     /locus_tag="KRO40_001772"
     CDS             4688..6175
                     /locus_tag="KRO40_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092593.1"
                     /translation="MKNGNDKNRIGKIKSKFKLKFSKKNISIKTRILLSILCLIIIVF
                     MIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFM
                     RNVQDKVRMAETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLN
                     SDENTRISTRNKDYYISTVKITSIYGEQDKYLILFIDISKTLNLAQKINIVLISVMCF
                     AGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVMNKSA
                     EYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSD
                     MVEDLLYISKIDNITKDFELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLF
                     ECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVIIEDDGIGIKKEDLPHVFE
                     RFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL"
     gene            6380..7993
                     /locus_tag="KRO40_001773"
     CDS             6380..7993
                     /locus_tag="KRO40_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2092594.1"
                     /translation="MKEQLIFNITNLVTVVFEAFVIHMFLSDFLGQKEGYIKVVRYAK
                     LGFIICLGFCNLITLNPKITMPLIFILIFSTSFLYKGNLKTRLFTTVLLSIFFILSEI
                     VVTSIFVLFVKEGFEIMLENNSIRVLATILSKIVFLLTCKIICLFKKDVHLDMPIKYW
                     LPLFLIPIFSLFLSVSIFDVSKFFSLESLKFLSLISSVGILYINFIVFYLFKFIIDKT
                     KLSMKYELLEKEIIHKEELRLSNECYKIIVEQTDSVVFEWNIKENKSFVSQAWTEKFG
                     YNNACKNIFKEIKDKDLVHSEDKAIFEGFLESIKKKNMHNQAVYRLKKSNGEYIWCRT
                     SITSIYNDENELLRVVGVIVDVDSDIKKYEELRTRAESDSLTNIYNKGTFEKLVEETI
                     VMNTGDKKDALFIIDLDDFKEINDNFGHPFGDFVLKTFADKIQTSFGSKDLVGRIGGD
                     EFVVYMQDYVTEVNLHKKAKELNRVLSDNYTDLSFSFDASVSIGIARYPQDGTSFFEL
                     FKNADRALYSIKASGKNSYCLFEEELYVQ"
     gene            complement(8356..9186)
                     /locus_tag="KRO40_001774"
     CDS             complement(8356..9186)
                     /locus_tag="KRO40_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2092595.1"
                     /translation="MSQVSKNYFTTGEFAKICGINKKTLFHYDDIGLFSPELKKENGY
                     RYYSYHQLSIFGIISSLREVKMPLKEIKAYIDKRTPNLLIELLEKKTIDIKNEIEKLN
                     NIQALMESTISFTKSACNIDANTITLKEHEEEYLVKTPVTYKEQFLGDEEENFLYECI
                     NFMDNYELSDYGTIGSIIKGEDIINKDFESYSYLFTKVNKEYKKYPVSIKPKGLYVTA
                     YHKGSYETIYKAYEKLLNFFNQNNLRIGDFVYEEYLLYDISVRDSNEYLTQISAEVKM
                     "
     gene            9259..10986
                     /locus_tag="KRO40_001775"
     CDS             9259..10986
                     /locus_tag="KRO40_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092596.1"
                     /translation="MKKLIHFLKPYRVLIVVVLIFTFLQTLGTLYIPTLTANIVNNGV
                     VKGDIDYIVKTGLMMMIVAGITALSAVLVCKVSANLSSGFCRDIREAVFIKSQDLSIN
                     DFNNIGTASMITRSTSDITLIGQSVFMFIQLVLPAPIITVSGLFLAYSIDKAMTIIIV
                     VVMFLFMLSAFLVGKKLIKLFKMMQIKMDNMNRVLREVVTGVRVIRAFNRSRFEKKRF
                     DRTAIDYSETAISINKIFAVLMPIVMLIMNLGIVSIIWFGGMRVSNGNMEIGHIMALV
                     EYCILILFYLIMGVMVFMYIPRAGACADRVNQILDIEPEIVDGNGHKDTVSERGHLVF
                     KNVTFSYAQSEEPVLNNITFEAKSGEVTAIIGSTGSGKSTIANIIPRFFEIQSGEISI
                     NGQDIKKIPQKELRDKIGFVPQKAFLFSGTIEENIRYGKEDASIEEVKHAASIAQADE
                     FIYDMEDKYDSFVAQGGNNLSGGQKQRISIARALVRKPEVYVFDDSFSALDFKTDKRL
                     RKALKNEIKDSSAIIIAQRISTIMDANQIIVLNDGKIVGIGKHKDLLENCEVYKQIAD
                     SQLSKEELA"
     gene            11023..12885
                     /locus_tag="KRO40_001776"
     CDS             11023..12885
                     /locus_tag="KRO40_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092597.1"
                     /translation="MSEKRIDEQDIEVLSFEDGMSAEKAKDAKKTTKRLLKYMAKQKF
                     KILIIFISVLISSALTVLAPMVMGKAIDQLFNGIKTAVQTGTKFSVNFSTMGGIVSIL
                     LGLYLISAVFIYIQQYIMSGVAQNLVLSMRKDLSDKLNKLPLKYYDSHKKGETLSIVT
                     NDLEKVADSLQEGLMQLITAVVTVVGSIVMMISISVPLTIVSAITLLVSLGITVVIAR
                     KSQERFSENQKALGELNSNIEEIFTGQIVVKAFSKEKDTIRNFKILNQNLYNASRKAQ
                     FSSYAISPIIRFINLIGYVIIAVVGGIFASTGAMTLGSIQAFIQYVNQASEPTTEISY
                     IVNMLQAAIASAERVFTVMDEVEEIKDEESSKVISMPKGKVQFEHVKFGYSDDFILMK
                     DININLNAGDKIAIVGPTGAGKTTLVNLLMRFYEIQGGRITIDGVNIKDLKRGELRTM
                     FGMVLQDTWLFNGSIKENIAYSKSDATMDEIVRAAKSARVDHFIRTLPQGYDTILTED
                     ASNLSQGQKQLLTIARAILSDPSVLILDEATSSVDTRTEVEIQKAMNNLMKGRTSFVI
                     AHRLSTIRDADLILVMKEGTIIEQGSHKELIEKKGFYEELYNSQFTSEYDEDVV"
     gene            13218..13907
                     /locus_tag="KRO40_001777"
     CDS             13218..13907
                     /locus_tag="KRO40_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyphosphate polymerase domain-containing
                     protein"
                     /protein_id="HBH2092598.1"
                     /translation="MNKKLNYRFEMKHKITEADVLALKSRLYPIMKKDENASKDGKYL
                     IRSLYFDTPEDKALLDKLNGVAIREKFRIRFYNNDCSYIRLEKKIKHYNMTSKLSTNL
                     TKKEVINILNNDIEFLKESTNCLLREFYLKLKCERLEAKSIVDYNREAFIYPVGNVRV
                     TIDSDIKTSVNSVDLFNKDLPTVSVIDENMTVLEVKYDEFIPDFIKDLIQINKTTSTA
                     VSKYASSRLYI"
     gene            14003..14689
                     /locus_tag="KRO40_001778"
     CDS             14003..14689
                     /locus_tag="KRO40_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4956 domain-containing protein"
                     /protein_id="HBH2092599.1"
                     /translation="MILIMTFNDIFKSSFIENVSGFSFVDSALALGSAFLVGLFIYMV
                     YKKTYMGIMYSRPFNVSLVALTMLTTFVILAVTSNVVLSLGMVGALSIVRFRTAIKDP
                     MDLVFLFWSLGSGIVLGAGLIPLAVMGSIIMGLILIFFSNKTISETPYILMVNCNNED
                     SEDIATDKIKKVFTKYQIKSKSVTPEKGIELVFEVRMKDGETSLINDLSQVDGVTNAV
                     LVSYNGDYVA"
     gene            14706..16613
                     /locus_tag="KRO40_001779"
     CDS             14706..16613
                     /locus_tag="KRO40_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CotH kinase family protein"
                     /protein_id="HBH2092600.1"
                     /translation="MKDKKFTLLISIMIIFLCAVVGVYSTSSNKSVDLYSDVYIEKYF
                     NRDKVMEVNIEIDESDLKDMNENAIKEEFKVAKVTVDGDTYGNVGIRTKGNSSLISVA
                     NSDSDRYSYKINFDKYNTSQSMEGLTQLNLNNCYSDPSYMREFLTYSICEEMGLATPE
                     FAYAKVSINGEYHGLYLAVEGLKESYLENNFGNVTGDLYKSDEGSSLQYKGDDPESYS
                     NLIVESDKKTADWSKITKLLKSLDTGEDIEKYLDVDSVLKNIAINTALLNLDSYQGSF
                     AHNYYLYEQDGVFSMLPWDFNMSFGGFSGFGGGSQSIAIDEPTTGNLEDRPLISSLLK
                     NETYKTKYHKYLEEIVTKYLDSDYLENMTTKLHDMIASYVKEDPTAFYTYEEFEKNIT
                     SSIEDSSDNKGFGNKGFDNNNSNNSDSNNNSNSENKHSGNQSDEKEVNAELTSSVVKA
                     NTDNENKNKTTNDSESKNNTDKDKSGNDNNQKLEGPMGKGGKSIPGVLEVAEDMSKTI
                     KSQLSGETSSTKQNSGDESSSGIKGSEKFDEDMSGMPEPPEGMDGKMPPGMGNMDKGD
                     MNGKNGNMNMDRNQDNPREAGGFGNRGGGSVSKTTTYFKLILGGASMIIMSIMLVGVS
                     RVKRRRFIKSK"
     gene            17065..17754
                     /locus_tag="KRO40_001780"
     CDS             17065..17754
                     /locus_tag="KRO40_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092601.1"
                     /translation="MLQKVLWKFLKLVVGLFICSVGIVLTINCNLGLSPWDVFHQGLS
                     NHIGITIGTASIIVGSIVVIADVVLGENVGWGTVFNMLLIGFFMDLLLYSNLIPEADN
                     LFVGIIMLILGLVLLSVGMVFYMGSGLGSGPRDGLMVAIQKKTGKSLKLIRGTIEVGA
                     LIVGFLLGGKVGIGTIISAFGLGYFTQMVFGLFKLDCSKIKHRFIVDDIKFIKVYMSG
                     EKKAAVQNIVK"
     gene            18190..18729
                     /locus_tag="KRO40_001781"
     CDS             18190..18729
                     /locus_tag="KRO40_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007286148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092602.1"
                     /translation="MDIGEKIKRLRTEKQLTQEELANRCELSKGFISQLENNLTSPSI
                     ATLIDILEILGTNLREFFNEIDDERISFTKEDMFETEDEDLKYKLKWLIPNSQKNEME
                     PIIITLYPGGQYKEEKPHEGEEFGYVLAGSIYVHIGEKKNKVKKGESFYFRPKANHYI
                     SNEGKTTAKVIWVSTPPSF"
     gene            18748..19791
                     /locus_tag="KRO40_001782"
     CDS             18748..19791
                     /locus_tag="KRO40_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092603.1"
                     /translation="MVENIIELRDISKHYEELTVLDNFNLDIKKNEFLTLLGPSGCGK
                     TTTLKIIAGFEYADDGKVLFEGKEINNLPPYERQVNTVFQKYALFPHMDVYENVAFGL
                     KIKKTPKDVIDAKVKEVLKLVALEGFERRQVESLSGGQQQRIAIARALVNEPKVLLLD
                     EPLGALDLKLRQEMQIELKRIQKKLGITFVFVTHDQEEALTMSDTIVVMYKGKIQQMG
                     TPQDIYNEPKNSFVAKFIGESNIFDGIMIEDYKVNFCNRDFECVDKGFEKNENIEVVI
                     RPEDIKMVKPEEGMLKGKVTSTVFKGVHYEIELNENGRLWILHNTKNAEVGTELGMDI
                     YPEDIHIMRKENN"
     gene            19793..20629
                     /locus_tag="KRO40_001783"
     CDS             19793..20629
                     /locus_tag="KRO40_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092604.1"
                     /translation="MKRKSFLAYPYVVWSAIFVIIPLILVVFFSFTKESGGGYAFTLE
                     NYKEVIDPIYMKVFGRSILLAGGATLICLIVGYPVAYIISKARVSRRGSLILLFILPM
                     WMNFLLRTYAWVAILGKNGLLNTFLGWFGIQPLAILYTNFAILLGMVYNFLPFMVLPI
                     YTALSKMDNDLINAAHDLGANNMTVFRKIIFPLSLPGVMSGITMVFMPAVTTFAISRL
                     LGGGKIMLVGDLIEQQFTVVGDWNFGSAISIFMMIVILISMSIMSKFGDESDKEGGGL
                     LF"
     gene            20734..21408
                     /locus_tag="KRO40_001784"
     CDS             20734..21408
                     /locus_tag="KRO40_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092605.1"
                     /translation="MARWNGFTWKWYGQLLQNESIMSALYYTIVIAILASVISTIVGT
                     ISAIGIHKMRGKSKKLILNVNYLPILNTEIVTAVALMSLFVFVKMEFGFTTMLLAHIM
                     FCLPYVILSVLPKMKQLPDNIEDAAMDLGATPIYALRKVILPQIKPGIVSGFLIAFTM
                     SIDDFIISFFNAGNGVSNLSIEIYGMARRGIKPEINALSTIMFAVVLGLLLLANKKES
                     IVRGIK"
     gene            21408..22460
                     /locus_tag="KRO40_001785"
     CDS             21408..22460
                     /locus_tag="KRO40_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spermidine/putrescine ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2092606.1"
                     /translation="MIKFKKAISLIAVGMMTVTLFTGCNKATDSTKVLNVYNVGDYID
                     ESLIDKFEKETGIDVQYSTYDTNEMMYQKVKSGSTHYDLVFPSDYMVEKMKNEGLLEK
                     LDFKNIPNMKYLDKSFLNPVYDKTNEYSVAYMWGTLGILYNKKEVKDPMDSWNILWNP
                     KYKGNIMMFDSVRDTIGITLKKLGYSMNSVNPKEINEAKNLLMKQKDLVLAYVNDEGK
                     DRLLGGEVAMGMLYSGDAVTLMEQNPDLDYAIPKEGTNKWVDAMCVPTTAQNKKEAEL
                     FINFLLDPENAKVNAEYIGYSTPNTGALKLLDPEITQNPVAYPSKEVLDKCETFEDIG
                     ENIKLYDKAWIELKSK"
     gene            22690..23538
                     /locus_tag="KRO40_001786"
     CDS             22690..23538
                     /locus_tag="KRO40_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2092607.1"
                     /translation="MNRINKKIDLLILALLVFIFLIVGIVILSIRTENKLNVFIMLAI
                     IFFIIMLTYLSNSVVGLITSSIIIFMYTSYILYNNITHNMDVEFISYMWIIATPVSSI
                     IMGNLNKSINELQNTNKKLSEQYKELVTIDSETGLRNLKIFYNDVNMEISKSIRHNTD
                     FSLMIVKLPYYGNLQTIFGENKTNKIVKYIGSNIIECTRNEDIIYSLQKDMIGILMPN
                     TSLEGSKVVKDRIKKRIKELNLDLNNRGKYVNIDVKIAFLQYKSSFGDSINFKNIVEE
                     ELQYDV"
     gene            23528..25192
                     /locus_tag="KRO40_001787"
     CDS             23528..25192
                     /locus_tag="KRO40_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2092608.1"
                     /translation="MMFKIFNKSLLKLVVVLSIVLTISNFSLSSYASEITSSTDKVLI
                     IYDSKKETAYNRDILNIMRTLLGRFSSDIELLKLSNYDGEINKNYYSHIFILGINENS
                     YNNDKNTKNLISSLNSYKGTICWLGYGIENLLEHKKYNLDYVGKTNNIVSVNYRGKSY
                     NLDEHYVFNIVESKDTSNKVIGSINDTLNKYPYIINDKNLFYVSKLDLDGVLFYIFCD
                     SLNDIFNIKTFDKGRIFVRIEDVHAFREPKNLVEIADYLSSKNIPFTIALIPAYVNPK
                     NHKVITLSESPEIVKAIKYMQDKGGTVILHGYTHQYKKEEVSGEGYEFWDGKKDEPLK
                     ENMKIFVKDRVLNGLRVCIENGIYPLAFEAPHYAMESEGYKELKKYFSTYIGQHQNND
                     KKFSTNTYPYIIRDTEEFNIFIPENLGYIDPEDKFTFQNIKENLDKLSIVRGFSGGFF
                     FHSYLNIEYLKNTIEYLEKQNIEFMNLRDFNNWVKVDEIQIRNNGDEIIVNYDKDLDE
                     LTKSDTRFKSISNISKVLIFIVSISVLIFVIIFIYFKRIDKKKFLK"
     gene            25241..26497
                     /locus_tag="KRO40_001788"
     CDS             25241..26497
                     /locus_tag="KRO40_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003362983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092609.1"
                     /translation="MRDLNVSEYLFVFSLFSIWSLLLINIILAMGGYIFYFKNFDKEI
                     KEIDEYPMISILVPAHNEAKVIGRTVESLLLLNYPKSKMELIVINDNSSDNSKEILEN
                     IKDRYNNYNFTIINTDSLTGGKGKSNALNIGYTISKGDFIAVYDADNTPDKNALRYLV
                     QTIVMNDELGAVIGKFRTRNKNKNLLTKFINIETLSFQWMSQAGRWQLFNLCTIPGTN
                     FILRRSIIEEIGGWDSKAIAEDTEISFRIYKLGYKIKLVPQSITWEQEPETVKVWIKQ
                     RTRWAKGNIYVLMKYIKNIFKQGRNKIVFDIAYFFSVYFLFLTSVIISDILFVLSISK
                     LVEISIPINFFLIWILSYLLFIIEVSISLTIEKGEATIENIFIVAIMYFTYSQLWLFV
                     AIKGMIEYLKDIIFKREVKWYKTERF"
     gene            26520..28601
                     /locus_tag="KRO40_001789"
     CDS             26520..28601
                     /locus_tag="KRO40_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulose biosynthesis cyclic di-GMP-binding
                     regulatory protein BcsB"
                     /protein_id="HBH2092610.1"
                     /translation="MKKFIISIISLVLFFSNISLIYKVNADETKVKNYKFERDITIDG
                     VIGSNSTFFEVNKNWDIEEVLLHLNFSKSQILNGDVSSLTVLINNVPIKSIKLNAKTN
                     YKNTLEVLVPKDYIIQGYNEIKIKTYKTISDKICQDDSNTGNWMVIHKESYISIRYKQ
                     KKVENSINEYPYPYAEIENNHKLDTTIVVPDNMTRGETTAVFNLASAFGKITKNDDLK
                     LDVKLYSEMKNWSDDNIIYIGKPENTAEEILDILSIKEQTLLSSNCIIKQVDSPYNKN
                     KKMMVVIGSNEDDLIKASNLLIENRLSNQVLSSSVLVNKETNIKINREQKLNLGHLTL
                     KDLGYSDFLLEGAFNQQALFDVKIPTGKVLDDGSKIILNLRYSDNLDFEKSLVTVSIN
                     DVIVGSKKLDRSHSNNDKLELKIPKDIDNKNYYQVKLTFNLSIKNSNCVTRESNNPWA
                     YVSNNSYLALSTKENETLSFENYPYPFVRDDEFNDLTVIMPDYSGSQAMTWMFRLGVT
                     LGANINSHNGNINVIRGKEFSDKYKDTNIVVFGVPHNNSVIKMLNNNLNIKFDKNYSN
                     FISNDKISFIDDYGKNISTIQLIKSPYNNQKNIMVISSMNEKNLYLGMDYLLNKSKVN
                     DLKGDTLIIDEYGEVEDLAYNLKSKKEVKDSSWNMSINKTTKVFLMISFITIIIVMIL
                     SMLYIKKYKRR"
     gene            28638..29723
                     /locus_tag="KRO40_001790"
     CDS             28638..29723
                     /locus_tag="KRO40_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH2092611.1"
                     /translation="MRKYMNEFKLKRSILISLIILIFIFIVYFVSIELKDRSLVNNQY
                     KGKIKSANLSVDYEINQVMKDIDKLGLNTVNVPIIINVESINSDIMSIDNNSKEKAIK
                     LIKKLNKKGISTILEAYPWIENGKLYETDWNPINKKRFFYTWQNAILNELIIDVANPL
                     DVNVLNIGSNFVHLEEYQQNWGEIIDFVQSKFDGLVTYRTNWWYTKKDDLSSKLFYEQ
                     KLNNNFFDKLDFISIAAYFELSNKPVNTVDELISALHSSTVNNRGQNIKQEIYNLYKA
                     HRKPIFFGELGFSNRESASSQPWNHTPSKAVNGEEQARCFEAYKKVFENEDWINGFSV
                     FCVGKIDDEKNFYPSKESIKVIKSWYE"
     gene            29777..30901
                     /gene="wecB"
                     /locus_tag="KRO40_001791"
     CDS             29777..30901
                     /gene="wecB"
                     /locus_tag="KRO40_001791"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="HBH2092612.1"
                     /translation="MNDIKVMTVFGTRPEAIKVAPLIKELEKRENIKSIVCVTAQHRE
                     MLDQVIETFNINVDYDLDIMEKGQSLNDITCKILNKLPLILNKENPNIILVHGDTTTT
                     LATSLTAFYNKTLVGHIEAGLRTYDKYSPFPEELNRQLTGIIADMHFAPTNLARKNLI
                     SEGKPNNNIFVTGNTAIDALKMTIKENYNHPIIDEIGNDRMILLTSHRRENLGKPMKN
                     IFRAIKRIVDDFEDVQIVYPIHLNPKIRTIADEIFGKFPEKIHIIEPLDVADFHNFLN
                     KSYMIMTDSGGIQEEAPSLGKPVLVLRDKTERTEGIEAKTLKLVGTNEDRIYNSVSDL
                     LINKDNYVQMSKASNPYGDGNASKYIVDIIIKKFNCKYLN"
     gene            30979..31953
                     /locus_tag="KRO40_001792"
     CDS             30979..31953
                     /locus_tag="KRO40_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBH2092613.1"
                     /translation="MARKLIKNLGKSKSVKRVKLLFKKIFITVFIVASIVAIFNITKY
                     FEELYKVRDLKSTKIEYYMDVADEAGDGKVQLSWKALLAIDMVIHDEDLSNIKKKDTL
                     DIGEKFIVEDKNGKGEKVYKVKKFNKVLSELKFDSSQKSRARKYMKDLEYTYLGNKQL
                     DSSDEKIKFIKKLEDSAIREYIDYGILPSITIGQAILESGWGNSKLTKQSNNLFGIKA
                     DKAWKGKSVEISTSEHYNEKIVASFRSYNSLQDSVKDHSLFLINNKRYRKHGLFEAKD
                     YISQAQALENAGYSTAEDKKGNRIYAELLIDVIRSYNLQLIDNKVETK"
BASE COUNT        12831 a         3189 c         5493 g        10583 t
ORIGIN      
        1 tatagtataa actccaattt cttttttgtc tttaggtttt attaaaattt ttacaaaata
       61 agttaaaaag tattgaaata aaatttcttt taaagtataa ttggtatata ccaaaattgg
      121 tatataccat atcgaaaagt ggtgactata tgaaaatagt aaataaatct agtaatatac
      181 cattgcatac tcaattaagt tcaataataa gagagatgat agaaactggt gagcttaaag
      241 agggtgatgc aataatgcca gaaagagaac tttgcaacat acaaaatgta agtcgtatga
      301 cagtaaataa aaccattgtt ggattagtta cagaaggact tctttatagg gtacaaggta
      361 aagggacatt cgttgcaaag caaaaaaaga agtatcagtt ttcaaatgta aaaggtttta
      421 ctgatgttat gaaagaaaag ggagtaaaca taaaaacgga tatattatcc tttgagatgg
      481 aactaccaga tgatttagtt aaaagaaagc ttggaataag tgataatact acaaatatat
      541 ataagattgt cagacttaga tatactgatg gagagccatt tggattagaa atagtatatc
      601 tatcagaaga aatgtgtaag ggtctaacaa aagggatatt ggataattct tcattatata
      661 gggttttaaa tgaaaaatat ggctataaga tacaaaaagc tgaacaggta atggagccag
      721 taatactttc agatgaagaa agtaagcttc ttgaaacaga tgaaggtgct ttagctctta
      781 aacttcatag aaattcctat aatagagaag gtagccctat agaatatacc atatcaatat
      841 ttagaacaga taaatatcaa tatgaaatag tattgagtga gtaggtgaat aatatgaaat
      901 gtttaattaa tggaaagata atattaaaaa atcaaatctt agaaaataaa gtattagtat
      961 ttgatgaaaa aataattgat atagctgata gtgtaccaaa agattgtgaa gttatagatg
     1021 ctgatggaaa atatatatct ccagggctta ttgatattca tatacatgga aacatgggaa
     1081 aagatacaat ggattcgact gatgaatcta ttgaaacaat ttcaaagtca attatgagac
     1141 atggagtaac atcttttctt ccaactacaa tgactatgga taaagaacat gtttatgatg
     1201 cacttgaagt tattaaaaaa gcccaaaata gaaagcttga aggggcacaa gtattaggag
     1261 cacatttaga aggacctttt ataaatgaga attataaggg agcacaaaat gaaaaattta
     1321 taataaattc aaaatacgaa tttataaaag aatataaaga tgttataaaa gttataactt
     1381 atgctccaga aaaagatatt gattttgatt ttactagaga aataaaaaga tgtacagata
     1441 tagttttatc tattggtcat agtaatgcaa attatgacca agctaaagaa gctataaatt
     1501 taggagtaac taatgtaact cacatgttca atgcaatgac tggtttaaac catagagacc
     1561 caggcgttgt tggtgcagca cttacaacta atgtgtacag tgagttaata gcagatacaa
     1621 tccatataaa taaagattta tttcaattta tactaaataa taaaggaaaa gaaagactga
     1681 ttttaataac agattctata gaagctggtg gtcttgaaga tggcaattat tctcttggag
     1741 gtcagaaagt catagttaag ggtaatgaag ctagacttga aaatggagca ttagctggaa
     1801 gtgtgttgtc tttaaataaa atggtattta acttcttaga taatacaaac cttaaagtga
     1861 atgaagcaat taatttagct tctttaaatc cagcaacatc tttgggaata aatgacaaaa
     1921 aaggaagctt agaaataggt aaggatgcag atatagctgt atttgatgag aatttagatt
     1981 gtaaaatgac actttgcttg ggggacgtag tatataaaaa tatatagtat acaaaacaaa
     2041 ccttaaagac agtaaaaaca atataaaaaa taataaatta aacttacatt agtaaaagta
     2101 gtagttaaaa tttaggagga ataagatgag agtattagtg tgtaaagatt atgatggaat
     2161 gagtaaaaaa gccgctgaaa tgatagcagc tcaaatagtt ttaaaaccaa attcaatact
     2221 gggactagct acaggaagta caccagtagg tatgtataga gatttagtaa aaaaatacaa
     2281 tgataatata gtagattttt cagatgtgat gagctttaat ttagatgaat attataagtt
     2341 accaatatct aatgaccaaa gctatgatta ttttatgaaa gagaatctat ttaatcatgt
     2401 aaacataaag ccagaaaata ctcatctacc aaatggaatg gctgatgata ttgaaaaaga
     2461 gtgtatgaac tatgaagctt ctatagatgc agctggtggt atagatgtac aagtacttgg
     2521 aataggtcgt aatgctcata taggttttaa tgaacctgat actaaatttg caaagagaac
     2581 tcatgtagtt gaacttacag agtctacaat agaagctaat gcaagattct ttaaatcaag
     2641 agaagatgtt cctaaaaaag ctgtaagtat gggaataggt tcaatattga agtctaagaa
     2701 aatattgctt ttagcttcag gagaagaaaa agctgatgca gtatataata ctgtttatgg
     2761 agatataact ccagaagttc ctggttctat acttcaactt cataaagaca ctatagttat
     2821 agtagatgaa gcagcagcaa gtaaattgaa tccaaaagat tataaattag tataagaata
     2881 gaatgtagtt taagtaaaaa atagctatca ttgagtaatc aaatttattt aatgatagct
     2941 atttttattt aaatttttta cttcttttta tttaaattag ttattattgt ttaaattact
     3001 tgcttattac tttttacgaa aactcgttat caagaagtat ccaaataaga tgttaaaaat
     3061 tattatgttt agtgggattc tatcaagcat aataaaatta cctataattg ggatattacc
     3121 aactggaaac ataaagaaga atacaggcat cagtgatagt aaaaaagatg gaaaacaaag
     3181 aagaagtaat cttggaatat caatatacca actaccatcc tttttgtatt ctctaatcaa
     3241 taattcagtt cctagtaata aaccaatacc accagaggaa attaaattaa taaaaatgta
     3301 tcttttaaag tcttgcatat aaccagtgta aaattgagta tagaaatcat aatttaattt
     3361 aacggctaaa aaatacataa gcaatagaat gattaaaaat aaaagatatc taagagcttt
     3421 tttcatttta aattctccct tcagaaatac tttatttagt tttattttgt tggaatctga
     3481 ttttatcatt tagtttaaga aatccataat attagtgaag aatgaaataa gtattatata
     3541 tgaataaata tttttagaat taaggtgaat tgtagtgctt aatataacta taatattaat
     3601 tgtttgaata ttcaataaaa agtttgaaaa atatcaattc tgatataaac tgaataaata
     3661 cagttgaata ttaaattatt attttatcaa aaatatgcaa agtactacac cttcaaatat
     3721 cacctaaagt aattaaaagg caattaaggt gaagtagttc aagtatttct aaaataagtt
     3781 taataaattc tataataatt tattttttgc cttaaaattg ccttaaaatc caaacaattt
     3841 taaaactaat gtactataaa aagctggtat aatttaaata tagtaaaaaa taagatttat
     3901 cttatctatt gggatttaat tatttaatca atatatttat accatttaat ttaaataaaa
     3961 agtctattaa ggagtgagct tatgagtaag ttaatttata tagcagatga tgaagataat
     4021 ataagaaatt tggtaaagac attcttaaaa aatgaaggtc atgatgttat ggattttaaa
     4081 acgggtgatg aacttttaga acaatttaat ataaaggagt gtgacttagt aatactagat
     4141 ataatgatgc ctggctcaag tggttttgaa gtatgtacaa aacttcgtga gaaaagtaca
     4201 gtcccaataa tcatgcttac tgcaagagat acagatatag attatattac agggataacc
     4261 ttaggtagtg atgattattt tacaaaacca tttagcccaa tgtctttggt tatgagagta
     4321 aaatctatat ttagaaggat agagtttgaa aagaaacaaa attatgataa atatagtaac
     4381 tcgatagata tggaattaaa atttggtgat gtaataataa ataaaaagaa taaaatcgtt
     4441 acaagtaaaa atgtaaatat agaccttaca ccaaatgaat ataacctatt gacttatttg
     4501 tttgaaaata tagatagagc agtttccaga gatgaattat taaacaaaat atggggatac
     4561 gatatagaag ttgagacaag ggctgctgat gatacagtga agagattacg taaaaaaatt
     4621 ttaaatacaa atattttaat agaaactgta tgggggtttg gatttaggtt gaaggagaaa
     4681 agttaagatg aagaatggaa atgacaagaa tagaattgga aagattaaat ccaaatttaa
     4741 attaaagttc tcaaagaaaa atataagcat aaaaactagg attttgttga gtatactttg
     4801 tttgataatt atagtattta tgataatatt agtatctttt aatgtatttc ttgatacata
     4861 tataaaaaca actgcgaatg aagaattgac aaagtctaca gaaatagtag aacatatgga
     4921 tagtaatttt agacctatta agccaccaca agatgatgga aagcttcctc ccaaagtatt
     4981 atctaatttt atgagaaatg tacaagataa agttaggatg gcagaaacac aatcagatgc
     5041 tgatgctatg gtagttgatt ctaagtataa cctgatattt ccaacaagag aggatgattt
     5101 cttaaaaaat gttgatgaga tggagctgat tagggagtgt attcaaaatg aaaaattaga
     5161 tttaaattca gatgaaaata cacggatatc taccagaaat aaggattatt atatttcaac
     5221 tgtaaaaatt actagtatat atggtgaaca agacaagtat cttatacttt ttatagacat
     5281 atcaaaaact ctaaatctag cacaaaagat aaatattgta ttaatatctg taatgtgttt
     5341 tgctggaata ttagcaatat ttacagctgt gattttatct gagaaaattg ctaaaccgat
     5401 aaaagagttg tgtgagtttg caaaaaaaat gggtcaagga gatttcaaaa gaacctactt
     5461 tgacttttca gataaagaat tagtagagct ctcaactgtt atgaataaga gtgctgagta
     5521 tctggataag tatgataatg aacaaaaaat attttttcaa aatgcatctc atgaattaag
     5581 gacaccactt atgtctatta aaggttatgc agaagctata aaatataatg ttatagatag
     5641 taaacatgca agtgatataa ttcttgaaga aagtgatagg ttaagtgata tggttgaaga
     5701 tttattatac atttctaaaa tagataatat aactaaagat tttgaacttg tagaatgtga
     5761 tttaagagaa gtactttcaa attgtggagc taggcaaaat gtaagagcta taaataaggg
     5821 gataaaattt atttatgaat ttgatgaaga aatggtttta tttgaatgtg atgaaaaaaa
     5881 catttccaaa gcatttatga atcttataga aaatgctttg agatacgcta agagtgaaat
     5941 aaaaatagtg tgtaagtata atcaaaaaaa tatagttgtg ataatagaag atgatggaat
     6001 tggaatcaag aaagaagatt tacctcatgt ttttgaaaga ttctataagg gagtaggagg
     6061 aaatcatgga attggattat caatagttaa atctattgta aataagcatg gtgggcgtat
     6121 atacgtagaa aatggcaaaa aaggagctaa atttactata ttatttaaat tgtaaaaaaa
     6181 ttagagaaaa tatagagatg tttgaagttg ttttttatat atatctgttg tatactgttg
     6241 aaaaaagaac aatattaagc tgacatatat tacgatagtt gacatttaaa gtaaatgctt
     6301 aaatatagat acgaaaggaa aagtaaaatc tgaagtgtat ttaggtttaa gtaagcttct
     6361 tattttataa aaaatatgta tgaaagaaca gctgattttt aatattacaa atttagtaac
     6421 ggttgtattt gaagcttttg tcatccatat gtttttatca gactttttag gtcagaaaga
     6481 agggtatata aaagttgtaa gatatgctaa actgggtttt ataatatgtt taggattctg
     6541 taatttaata actttaaacc ctaaaatcac aatgccttta attttcatcc ttattttttc
     6601 aacatcattt ttatataaag gaaatttaaa gacacgattg tttactactg ttttattaag
     6661 tatattcttt atactgtcag aaattgtagt tacaagtatt tttgttttat ttgtaaaaga
     6721 aggctttgaa ataatgcttg aaaataatag tataagagta ttggcgacaa ttttatctaa
     6781 aattgtcttt ttgttgactt gtaaaattat ttgtctattt aaaaaggatg tacatttaga
     6841 tatgcccata aagtattggc tccctttatt tttaatacct atatttagtt tatttctgtc
     6901 tgtttctatc tttgatgtaa gtaaattttt tagtcttgaa agtttaaaat ttctaagctt
     6961 aatatctagt gttggtattt tatatattaa ttttattgtc ttttatttat ttaaatttat
     7021 tatagataaa actaaactat ctatgaaata tgaactactt gaaaaagaaa taattcataa
     7081 ggaagaatta agacttagta atgagtgtta taaaattatt gttgaacaga ctgattctgt
     7141 cgttttcgaa tggaatatca aagaaaataa atcatttgta tcgcaggctt ggactgaaaa
     7201 atttggatat aacaatgcat gtaagaatat ttttaaagaa attaaagata aagacttagt
     7261 tcattctgaa gataaagcta tatttgaagg ttttcttgaa agtattaaaa aaaagaatat
     7321 gcacaatcaa gcagtatatc gtttaaaaaa atctaatggt gaatatattt ggtgtagaac
     7381 atcaattaca agcatttata atgatgaaaa tgaactttta agagttgtcg gagtaattgt
     7441 agatgtagat agtgatataa aaaaatatga agagttaaga actagagcag aaagtgactc
     7501 attgaccaat atatacaata aaggtacatt tgaaaaatta gtggaagaaa ctatagttat
     7561 gaatacaggt gataaaaaag atgcattatt cattattgat ttggatgatt ttaaagaaat
     7621 aaatgataat tttggtcatc catttggtga ttttgtacta aaaacatttg ctgataagat
     7681 acaaactagt tttggtagta aagacttagt cggaagaatt ggtggagatg aatttgttgt
     7741 atatatgcaa gattatgtta cagaagtaaa tttgcataaa aaagctaaag aattaaatag
     7801 agtactttcg gataattaca ctgatttgag ttttagtttt gatgcttctg tcagtatagg
     7861 tattgcaagg tatcctcaag atggaacttc attttttgaa ttgtttaaaa atgcagatag
     7921 agcactttat agcataaaag catcaggtaa aaattcatat tgtttatttg aagaagaact
     7981 atatgtacag tgaatttgaa tttagatttt atgtgagagt aagatttata tatacttgtg
     8041 gctgtctgat ttataaaata tgttactttg tatattttta tatgtttcag taaggttaat
     8101 taacatgagc aaaggtgtaa gtaaatttat attagtttaa gtttacttac acctttataa
     8161 aaatacaaat aatagattca tttacattct taaatgatta aagctcttta ccttctaaac
     8221 atgcataaca tatcgttata attccagtaa ataagactaa aatgcccatt actaagatta
     8281 caatttcatc atctattact ccaaatgttt ttaaagtaac ttatttcgct ttgtatcata
     8341 ataatttgtc tctttttaca ttttaacttc tgctgagatt tgagttagat attcattaga
     8401 atctcgcaca cttatatcat atagaagata ttcttcataa acaaaatccc caatacgtaa
     8461 attattctga ttaaaaaaat ttaataactt ttcataagcc ttgtaaatag tttcataact
     8521 ccctttatga taagcagtta cataaagtcc ctttggtttg attgatacag gatatttctt
     8581 gtactcttta ttaacttttg taaataaata tgaatatgat tcaaagtctt tattaattat
     8641 atcttcacct ttaatgattg agccaatcgt accataatca ctcaattcat agttgtccat
     8701 aaagttaata cattcatata aaaaattttc ttcctcatct cctaaaaact gttctttata
     8761 tgtaacaggt gttttgacca agtactcttc ttcatgttct tttaaagtaa tagtattcgc
     8821 atctatatta catgcacttt tagtaaatga aatagtagat tccattagag cttgaatatt
     8881 atttagtttt tcaatttcat ttttaatatc aatggttttc ttttctaaaa gctcaattag
     8941 taaattaggt gttcttttgt ctatataagc tttaatttct tttaaaggca tttttacttc
     9001 cctaagtgaa gaaattatac caaaaatgct aagttgatgg tatgagtagt atctatatcc
     9061 attttctttc tttaattctg gtgagaaaag acctatatca tcataatgga aaagtgtttt
     9121 tttattgatt ccacaaatct ttgcaaattc tccagttgta aaataatttt ttgaaacttg
     9181 actcataatt ataattcctc cttgactatc ctgttacagt atagtttatc atagtatttt
     9241 gtaaaggagt gtgattatat gaaaaaatta attcattttt taaaaccata tagagtttta
     9301 attgttgtag ttttgatatt tacgttttta caaacacttg gaactttgta tataccaaca
     9361 cttacagcaa atatagtaaa taatggtgta gtaaagggag atatagatta tattgtaaaa
     9421 acaggtttaa tgatgatgat agtagctggt ataacagctt tatcagctgt gttagtttgt
     9481 aaagtatcag caaatctttc atctggattt tgtagagata ttagagaagc agtatttata
     9541 aaatcacaag atttatcaat aaatgatttt aataatatag gtacagcatc aatgattact
     9601 aggagtacta gtgatattac tttaataggt cagtctgtgt ttatgtttat tcaattagta
     9661 ttaccagcac caattataac tgtttctggt ctattcttag catattctat agataaagca
     9721 atgacaatta ttattgttgt agtaatgttt ttattcatgc tttcagcatt tttagttggt
     9781 aaaaagctta taaagttgtt taaaatgatg caaataaaga tggataatat gaatagggtg
     9841 ttacgtgagg tagtaactgg agtaagagtt ataagagctt ttaataggag tcgttttgaa
     9901 aaaaagagat ttgatagaac tgcaatagat tattctgaaa cagcaatttc aataaataaa
     9961 atatttgcag tacttatgcc tattgtaatg ttaataatga atttaggtat agtaagtatt
    10021 atttggtttg gtgggatgag agtcagtaat ggaaatatgg aaataggtca tataatggca
    10081 cttgttgaat attgtatctt aattttattc tatttaatca tgggagtaat ggtatttatg
    10141 tacataccta gagcaggtgc atgtgcagat agagtaaatc agatattaga tatagaacct
    10201 gaaattgtag atggaaatgg tcataaagat actgtctcag agagaggaca tttagtattt
    10261 aaaaatgtaa ccttttcata tgcacaatca gaagaacctg tgttaaataa tataacattt
    10321 gaagcaaaat ctggagaagt aactgcaatt ataggaagca ctggctcagg caaatctact
    10381 attgcaaata taataccacg tttttttgaa attcaatctg gagaaatatc tataaatggt
    10441 caggatatta agaagattcc tcaaaaagaa cttagagata agattggatt tgtaccacaa
    10501 aaagcttttt tatttagtgg aacaatagaa gaaaatataa ggtatggaaa agaagatgca
    10561 agtattgaag aagtaaagca tgctgcaagt atagctcaag ctgatgaatt tatttatgat
    10621 atggaagaca agtatgactc atttgtagca caaggtggaa ataatttgtc aggtggtcaa
    10681 aaacagagaa tatccattgc aagagcgtta gttagaaagc ctgaagtata tgtctttgat
    10741 gatagttttt ctgcattaga ttttaaaaca gataaaagac ttagaaaagc gttgaaaaat
    10801 gaaatcaaag attcatcagc tataattata gcacaacgta taagtacaat catggatgct
    10861 aatcagatta tagttttaaa tgatggaaaa attgtaggta ttggaaaaca taaagattta
    10921 cttgaaaatt gtgaagttta taagcaaatt gcggattcac aacttagtaa agaagaactt
    10981 gcataaaatg aagaattaat ctgatatttg gaggtgtatg atatgagtga aaaaagaata
    11041 gatgaacaag atatagaagt acttagtttt gaagatggca tgtcagcaga aaaagctaag
    11101 gatgcaaaaa aaactactaa gagattatta aaatatatgg caaaacaaaa gtttaaaata
    11161 ttaattattt ttatttcagt attgataagt tcagcgctta cagttttagc acctatggtt
    11221 atgggaaaag ctattgacca actatttaat ggaataaaaa ctgcagtcca aacaggtaca
    11281 aaattcagtg tgaattttag tactatggga gggatagtat caatacttct agggttgtac
    11341 ttaattagtg cagtatttat atatattcaa cagtatatta tgtcaggagt tgcacaaaat
    11401 ctagttctta gcatgagaaa agatttaagt gataaactca ataaacttcc tcttaagtac
    11461 tatgattctc ataaaaaggg ggaaacactt agtatagtaa caaatgattt agaaaaagta
    11521 gcagatagtt tacaagaagg attaatgcaa cttattacag cagtagttac agtagttggt
    11581 tctattgtaa tgatgataag tataagtgta ccacttacaa tagtatcagc tataacatta
    11641 cttgtttcat tgggtattac tgttgtaatt gcaagaaaat cacaagaaag attctctgaa
    11701 aatcaaaagg cactaggaga gttaaatagc aatatagaag agatatttac tggtcaaata
    11761 gtggttaaag catttagtaa agaaaaggat actataagaa actttaaaat attaaatcaa
    11821 aatctttata atgcaagtag aaaagcacag ttttcgtcat atgcaatatc tccaattatt
    11881 agatttataa acctaattgg ctatgttatt atagcagttg taggtgggat atttgcatca
    11941 actggagcaa tgactcttgg tagtatacaa gcgtttattc aatatgtaaa tcaagcatca
    12001 gagcctacta cagaaatatc ttatattgta aatatgcttc aagcagcaat agcatctgca
    12061 gagagagttt ttacagttat ggacgaggtg gaagagataa aggatgaaga atcttcaaag
    12121 gttattagca tgcctaaagg taaagtacaa tttgagcatg ttaaatttgg atatagtgat
    12181 gattttattc ttatgaaaga tattaatatc aatctaaatg caggagataa gattgcaatt
    12241 gttggaccta caggagctgg aaagacaact cttgtaaatt tacttatgag attttatgag
    12301 atacaaggtg gaagaattac tattgatggt gttaatataa aagatttaaa gcgtggagaa
    12361 cttagaacta tgtttggtat ggttcttcaa gatacatggc tatttaatgg aagtataaaa
    12421 gaaaatattg catatagtaa gtcagatgcc acaatggatg aaattgtaag agcagcaaaa
    12481 tcagcaagag tagaccattt tataaggact ttaccacaag ggtatgacac tatattgact
    12541 gaggatgctt ctaatctatc tcaaggtcaa aagcaacttc taacaattgc cagggcaata
    12601 ctttcagacc catcagtatt gattcttgat gaagcaacat ctagtgtaga tactagaaca
    12661 gaggtagaaa ttcaaaaggc aatgaataac ttgatgaagg gaagaactag ttttgttatt
    12721 gcacatagat tatcaactat tcgagatgct gatttaatat tagtaatgaa agaaggaact
    12781 attattgaac aaggaagcca taaggaactt attgaaaaga aaggattcta tgaagaactt
    12841 tataacagtc aatttacaag tgaatatgat gaagatgttg tatgattatc aagttttagg
    12901 caactaaatg attgataaat attaagttaa atatagtaac atgtaaggtt atatggaata
    12961 agagtatttc tctatttcat ataacctttt ttatttatca aaataagata aaatttcctt
    13021 tctaaattag attgaagaat gtatttatca atataaaagt aaaataatca ttattattag
    13081 tgaagtaaat attgtttgcc acatatatgc cataaagatg cacttatttt acggagattt
    13141 aacaaagtag tgtaaagtat actctaaata taaaataaat caaatagagt taaataaatt
    13201 gagaggtgat ataaatagtg aataaaaaat tgaactatag atttgaaatg aagcacaaaa
    13261 taactgaagc agatgtgtta gctttaaaat caagactcta tccaataatg aagaaagatg
    13321 aaaatgcatc taaagatgga aaatatctta ttaggagttt atattttgat actcctgaag
    13381 ataaagcact tttggataaa ttaaatggcg ttgcaataag agaaaagttt aggataagat
    13441 tttataataa tgactgctct tatataaggt tagagaaaaa aatcaaacat tacaacatga
    13501 catcaaagct atcaactaat ttaaccaaaa aagaagtaat aaatatacta aataatgata
    13561 ttgaatttct aaaagagtcg acaaattgtt tattaagaga attttatttg aaattaaaat
    13621 gtgaaagatt agaggcaaaa agcatagttg attacaatag agaagctttt atttatccag
    13681 ttggaaatgt aagagttaca atcgatagtg atattaaaac ttctgtaaat tcggtagatt
    13741 tatttaataa agatttgcca actgtttcgg taattgatga gaatatgact gtattggagg
    13801 ttaaatatga tgaatttata ccagatttta taaaggattt aattcaaatt aataagacta
    13861 cctctacagc agtttcaaag tatgcttcaa gtagattata tatttaagaa taaaggctat
    13921 gatttatata aagatataca taaataagat taaaaaacaa ataagttaaa aataaaaaat
    13981 aaataagtta aaaataggaa ggatgatttt aattatgaca tttaatgata tttttaaatc
    14041 aagttttata gaaaacgtat caggtttttc atttgtggac agtgctttag cactaggttc
    14101 agctttttta gtaggtttgt ttatatatat ggtctataaa aagacttata tgggaattat
    14161 gtattctcga ccattcaatg tgtcgcttgt agcacttaca atgcttacaa cttttgtaat
    14221 attggcagtt acttcaaatg tagttttatc cttaggtatg gttggtgctt tatctatagt
    14281 aagatttaga acagcaatta aagacccaat ggatttagta tttctatttt ggtcattggg
    14341 ttcaggtata gttttaggag caggtttgat tcccttagct gtcatgggtt caataattat
    14401 gggattgatt ctaatattct tttcaaataa aacaatatct gaaactccat atatattgat
    14461 ggtaaattgt aataatgaag attcagaaga tatagcaact gataaaatta aaaaagtatt
    14521 tactaaatat caaataaaat caaaaagtgt tacaccagaa aaaggaatag aattagtgtt
    14581 tgaagtaaga atgaaagatg gagaaacaag tcttataaat gacttgagtc aagtagatgg
    14641 agttactaat gcagttcttg taagttataa tggtgactat gtagcataga gaggagtaat
    14701 cttttatgaa agataaaaaa tttacccttc ttatctcgat tatgattata tttttatgtg
    14761 ctgtagttgg agtttatagt acatctagca acaaaagtgt tgatttatat agtgatgtat
    14821 atattgaaaa atattttaac agagacaagg ttatggaagt taatatagag atagatgaaa
    14881 gtgacttgaa ggatatgaat gaaaatgcta taaaagaaga atttaaggtt gcaaaagtaa
    14941 ctgtagatgg agatacatat ggaaacgtag gtataagaac taaaggaaat tcaagcctta
    15001 tatctgtagc aaatagtgat agtgatagat acagctataa gattaatttt gataagtata
    15061 atactagtca aagtatggaa gggcttactc aattaaatct taataactgt tactctgacc
    15121 catcttatat gagagagttt ttaacatata gtatttgcga ggaaatggga ttagcgactc
    15181 cagaatttgc atatgctaaa gtctctataa atggcgaata tcatggtttg tatttggcag
    15241 tagaaggatt aaaagagtct tatcttgaaa ataattttgg taatgtaact ggagacttat
    15301 ataagtcaga tgaaggaagc tcgttgcaat ataaaggaga tgacccagaa agttactcaa
    15361 acttaatcgt tgaaagtgat aaaaagacag ctgattggtc taaaattaca aaactattaa
    15421 aatctttgga tacaggtgaa gatattgaaa aatatcttga tgtagattct gtccttaaaa
    15481 atatagcaat aaatacagct ttattaaacc ttgatagcta tcaagggagt tttgcccata
    15541 actattattt atatgagcaa gatggagtat tttctatgtt accatgggat tttaatatgt
    15601 catttggtgg atttagtggt tttggtggag gtagtcaatc tatagcaatt gatgaaccta
    15661 cgacaggtaa tttagaagac agacctctca tatcctcgtt attaaaaaat gagacataca
    15721 aaacaaaata ccataaatat ctggaagaga tagtaacaaa atacctagat tcagactatt
    15781 tagagaatat gacaacaaaa ttgcatgaca tgatagcatc atatgtaaaa gaagacccaa
    15841 cagcatttta tacttatgaa gaatttgaaa aaaatataac atcttcaatt gaagattcta
    15901 gtgataataa gggatttggt aataaagggt ttgacaacaa taactctaat aacagtgatt
    15961 ctaataataa ttctaatagt gaaaataagc actctggaaa tcaaagtgat gaaaaagaag
    16021 ttaatgctga attaacatca agcgtagtca aagctaatac agataatgaa aataaaaata
    16081 aaactacaaa tgatagtgaa agtaagaata atacagataa agataaaagt ggaaatgata
    16141 ataatcaaaa gctagaaggt cctatgggta aaggaggtaa gtcaatacca ggggttttgg
    16201 aagttgcaga agatatgagt aaaactataa aatctcaatt aagtggagaa acttcttcga
    16261 caaagcaaaa ctctggtgat gaaagttcaa gtggaattaa aggtagtgaa aagtttgatg
    16321 aggatatgag tggtatgcca gaaccaccgg agggaatgga tggtaaaatg ccaccaggaa
    16381 tgggtaatat ggataaggga gatatgaatg gtaaaaatgg caatatgaat atggatagaa
    16441 atcaagataa tccaagagaa gctggaggtt ttggcaatag aggaggaggc tctgtgagta
    16501 aaacaacaac atacttcaaa ttaattttag gtggagcttc aatgataata atgtcgatta
    16561 tgttagttgg tgtatcaagg gtaaagagaa gaagatttat aaagtcaaaa taagattaaa
    16621 attgaatata aataatttta atactgttaa gtctaaatat ttacttagca gtatttttta
    16681 gaaaataatg tatttggtta ctaatataag gtaataaatt gataaaaatt aaatacagca
    16741 tattaataat acataataaa gtaataaaaa aactgtttaa gtataataac ttatatttag
    16801 acagtttttt tcatttataa ataatataaa tgaaattgaa aacatttgaa ggatagaaat
    16861 tggttggata aatgtataaa ttacttcacc aaaaaataat gacaaaaatt gtaactaagt
    16921 tgtaataaaa tggtagttat ttagcataaa ataatgtatc atagaagtat attataaaat
    16981 taataaaata agatttttgt aagaaaactg ctggcttttg atatttagag tgagtagtta
    17041 aattatgttt aggaggggta gaatttgttg caaaaagtat tatggaaatt tttaaagcta
    17101 gtagtcggtt tatttatatg ttcagttggt atagtattga cgataaattg taaccttgga
    17161 ttatctccct gggatgtatt tcatcaagga ctttcaaatc atataggaat aactatagga
    17221 actgcttcta taattgtagg ctctatagta gttattgctg atgtcgttct tggagaaaat
    17281 gtaggatggg gaactgtttt taacatgcta ctaattggat tttttatgga tttactttta
    17341 tatagtaatt taattccaga ggctgataat ttatttgtag gaataattat gttgatatta
    17401 ggattggttc ttttgtctgt tggaatggta ttttatatgg gaagtggttt aggaagtgga
    17461 cctagagatg gtttgatggt tgcaattcaa aagaaaacag gaaaatcact taaattaata
    17521 agaggtacta tagaagttgg agcattaata gtaggatttt tattaggtgg aaaagttggt
    17581 ataggaacta taataagtgc atttggattg gggtatttca cacaaatggt atttggctta
    17641 tttaaattag attgtagtaa gattaaacat agatttatag tagatgatat aaaatttatc
    17701 aaagtgtata tgagtggtga gaaaaaagct gctgttcaaa atatagttaa gtaatttaag
    17761 aataaattca acgaaatgtt aagtatttta aattaacatt ttgtttagat agataaattg
    17821 aatattaaaa gaatattaaa atatgaggat tgctagaaca ctataaaata tagatttcta
    17881 gtaatttttt atttgttcaa tattttttta gtactagaag tcttattctc tatttaatga
    17941 atgaattaat ttataattag agatactaaa ctttatagat attaatataa acacctttaa
    18001 actgtgtatt ttccaaagcc tttaaaatgc ttgtatttat tctaaataaa aaaataaaaa
    18061 aatgtcaaaa aaactcttgt attatatcca aattttatat ataattacct atgttgttta
    18121 gaaattttaa actcaatgtt tagtaaacaa aatgtttagt aaaataaaac agaaactagg
    18181 aggtgcaaca tggatatagg tgaaaagata aaaagattaa gaacagaaaa acaactgacc
    18241 caggaagagt tagctaatag atgtgaattg tcaaagggat ttatttctca attagaaaat
    18301 aacttaacat caccatccat agctaccctt atagatatac ttgaaatact aggtacaaat
    18361 ttaagggaat tttttaatga aatagatgat gaaagaatca gttttacaaa agaagatatg
    18421 tttgaaactg aagatgaaga tttaaaatat aaattaaagt ggttaattcc aaattcacaa
    18481 aaaaatgaaa tggagccaat aataataaca ttgtatccag gaggacagta taaagaagaa
    18541 aagccacatg aaggtgaaga atttggatat gtattagcag gttcaatata tgtccatata
    18601 ggcgaaaaga aaaataaagt aaaaaaagga gagagttttt actttagacc gaaagcaaat
    18661 cactatatat caaacgaggg caaaactaca gcaaaagtga tttgggtaag tacgccacca
    18721 tcattttaga atagaggtgt ttaataattg gtagaaaata taatagaatt aagggatata
    18781 tctaaacatt atgaagaact tactgtttta gataatttca atttagatat aaagaaaaat
    18841 gagtttctaa cattgcttgg accaagtgga tgtggaaaaa ctacaacatt aaaaataata
    18901 gcaggatttg agtatgctga tgatggtaaa gttttatttg aaggtaagga gataaataat
    18961 ttgccaccat atgaaagaca agtaaacaca gtatttcaaa aatatgcttt atttccacac
    19021 atggatgttt atgaaaatgt agcttttgga ttaaaaatta aaaagactcc aaaagatgta
    19081 atagatgcta aagtaaaaga ggttttgaaa cttgttgcac tagaaggttt tgaaagacga
    19141 caagttgaat cattgagtgg aggacaacaa caaagaattg caatagcaag agctctagtc
    19201 aatgaaccaa aggtattatt actagatgaa ccacttggag cacttgattt aaagttaaga
    19261 caagagatgc aaatagaatt aaagagaatc caaaaaaaat taggaataac atttgttttt
    19321 gtaactcatg accaagaaga ggctcttact atgtcagata ctattgttgt aatgtataag
    19381 ggcaaaattc aacaaatggg aacaccacaa gatatataca atgaacctaa aaattcattt
    19441 gtagctaagt ttataggtga aagtaacata tttgatggaa ttatgataga agattataaa
    19501 gttaatttct gtaatagaga ttttgagtgt gttgataaag gattcgaaaa aaacgaaaat
    19561 atagaagtag taataagacc agaagatata aaaatggtaa agccagaaga aggaatgtta
    19621 aaggggaaag ttacatctac agtgtttaaa ggagtgcatt acgagataga attgaatgaa
    19681 aatggaagat tgtggatact tcataatact aaaaatgctg aggttgggac tgaactaggc
    19741 atggatatat atccagaaga tatccatata atgagaaaag agaataacta agatgaaaag
    19801 aaaatctttt ttagcatatc catatgtagt ttggagtgcg atatttgtaa taattccttt
    19861 aatattagta gtatttttta gttttacaaa agaatcaggt ggaggttatg cctttacact
    19921 tgagaattat aaagaagtaa ttgaccctat atatatgaaa gtttttgggc gttctattct
    19981 tttagcagga ggagctacat taatatgcct tatagttggt tatccagtgg catatataat
    20041 ttcaaaggct cgtgtaagta gaagaggttc attaatatta ttgtttattc ttcctatgtg
    20101 gatgaacttt cttttaagaa catatgcatg ggttgctata ttaggaaaaa atggactttt
    20161 aaatacattt ttaggttggt ttggaataca accattagca attttgtata ctaattttgc
    20221 tatactttta ggtatggtgt ataacttttt accatttatg gttcttccaa tatatacagc
    20281 actatcaaag atggataatg atttgataaa cgctgctcat gacttgggtg caaataatat
    20341 gacagttttt agaaaaatta tatttccttt gagtttgcca ggtgtaatgt ctggaataac
    20401 tatggtattt atgccagcag tcactacttt tgcaatatca agactgttag gtggaggtaa
    20461 aataatgctg gttggagatt tgattgaaca acagtttaca gttgttggag attggaactt
    20521 tggttcagct atatcgatat ttatgatgat agtaatatta atatctatgt ctataatgtc
    20581 aaaatttgga gatgaatctg acaaagaagg cggtgggtta ctattttaaa attaaagaaa
    20641 ataacttcta atatatattt agcattagta ttcttatttt tgtatgcacc catatttgct
    20701 ttggtactat tttctttcaa tgattcaaaa tcaatggcaa gatggaatgg atttacatgg
    20761 aagtggtatg gtcaattact tcaaaatgag agtataatga gtgctttata ttatactatt
    20821 gtaatagcta tattagcgtc tgtaatatct acaatagtag gaactataag tgctatagga
    20881 atacataaga tgagaggtaa gagtaagaaa ttaatactaa atgtaaacta tcttcctatt
    20941 ttaaatacag agatagttac agcagtagct cttatgagtc tgtttgtatt tgtaaaaatg
    21001 gaatttggat ttacaacaat gctattggca catataatgt tttgtttgcc atacgttata
    21061 ctttcagttt tgccaaaaat gaagcaatta cctgataata tagaagatgc agctatggac
    21121 ttgggagcaa cacctatata cgctcttaga aaagtaattt taccacaaat aaaaccaggt
    21181 atagtttctg gatttttaat tgcatttact atgtcaatag atgactttat aataagtttc
    21241 tttaatgctg gaaatggtgt aagcaatctt tctatagaaa tctatggaat ggctagaaga
    21301 ggtataaaac ctgaaataaa tgcattatca acaataatgt ttgcagtggt tctaggttta
    21361 cttttactag ctaataaaaa agaatctata gtaaggggga ttaaataatg attaagttta
    21421 aaaaagcaat atcccttata gctgtaggta tgatgacagt tactttattt acaggatgta
    21481 ataaagcaac tgattctaca aaagttttaa atgtatataa tgttggagat tatatagatg
    21541 agtctcttat agataagttt gaaaaagaaa caggaataga tgttcaatat tcaacttatg
    21601 atactaatga aatgatgtat caaaaagtaa agagtggtag tacacactat gatttagtat
    21661 ttccttcaga ctatatggta gagaaaatga aaaatgaagg tcttttggaa aaattagatt
    21721 ttaagaatat acctaatatg aaatatttag ataagagttt tttaaatcct gtatacgaca
    21781 aaactaatga atatagtgtt gcatatatgt ggggaactct tggaatattg tacaataaga
    21841 aagaagttaa agaccctatg gatagctgga atatactttg gaatccaaag tataagggaa
    21901 atataatgat gtttgactct gttagagata ctatagggat aactcttaaa aaattaggat
    21961 atagcatgaa tagtgtaaat ccaaaagaaa taaatgaagc taaaaatctt ttaatgaaac
    22021 aaaaggattt agtattggct tatgtaaatg atgaaggtaa ggatagattg cttggtggag
    22081 aagtggcaat gggtatgctg tattctggag atgcagttac actaatggag caaaatcctg
    22141 accttgatta tgctatacct aaagagggaa ctaataaatg ggtagatgct atgtgtgtac
    22201 ctacaacagc acaaaataag aaagaagctg agctgtttat aaacttttta ttagacccag
    22261 agaatgcaaa agtaaatgct gagtacattg ggtattcaac acctaataca ggagcactaa
    22321 aattattaga cccagaaata actcagaatc ctgttgcata tccatctaaa gaagtacttg
    22381 ataaatgtga aacttttgaa gatattggtg aaaatataaa attatatgac aaggcttgga
    22441 tagagttaaa atcaaaatag ggtcttgttg ttttaagtaa atttacttaa taaatactta
    22501 ataaaactgt tcttttttag aaaatttatt ttctaattat tgaacagttt tattttttgt
    22561 ttaagttata ttcatatgca atttaaatag tttattaata aatgaaaact tatttgtata
    22621 atgactttaa taataattag aaaaaatggg caacttaata gaataattgg aggtgtaaat
    22681 ttataaaaaa tgaataggat aaataaaaaa atagatttat taatattggc tttgctcgtt
    22741 tttatatttt taattgttgg aatagtaata ctatcgatta ggacagaaaa taaattgaat
    22801 gtgttcataa tgttagcaat aatttttttt ataataatgt taacttattt atcaaattca
    22861 gtagtggggt tgataacaag ttcaataatt atatttatgt atacatccta tattttatat
    22921 aacaatatta ctcacaatat ggatgttgaa tttatatcat atatgtggat aatagcaaca
    22981 ccagtatctt caattataat gggtaatctg aacaaaagca taaatgaatt gcaaaataca
    23041 aataaaaaac tatctgaaca gtataaggaa ttagtgacta ttgatagtga aactggactt
    23101 agaaatttaa agatttttta taatgatgta aatatggaga taagtaaatc tattagacat
    23161 aatactgatt tttctcttat gatagtaaaa ttaccatact acggaaacct acagactata
    23221 tttggtgaaa acaaaactaa taaaatagta aaatatattg gttcaaatat tatagaatgt
    23281 acaagaaatg aagatataat ttatagttta caaaaagata tgatagggat actaatgcca
    23341 aatacatctt tggaaggttc aaaagttgtt aaagacagaa taaagaaaag gataaaagaa
    23401 ttaaatttag atttaaacaa taggggaaaa tatgtaaata tagatgtcaa aattgcattt
    23461 ttacaatata agagtagttt tggagatagt ataaatttta agaatatagt tgaagaggaa
    23521 cttcaatatg atgtttaaaa tatttaataa aagtctatta aaattagtag ttgtattatc
    23581 aatagtactg acaatatcaa attttagctt atcttcatat gcatcagaaa ttacttccag
    23641 cacagataag gtattaatca tatatgattc taagaaagaa acagcttata atagagatat
    23701 tttaaatatt atgaggactc tattgggaag atttagttca gatatagagc tattaaaatt
    23761 gagtaactat gatggtgaga taaataaaaa ttattacagt catatattta ttttaggaat
    23821 caatgaaaac tcatataata atgataaaaa cactaaaaac ttgattagtt ccttaaattc
    23881 atataaagga actatatgtt ggttaggata tggtatagaa aatcttttgg aacataaaaa
    23941 atacaattta gactatgtag gaaaaacaaa caatatagtt agtgtaaatt atagaggtaa
    24001 atcatataac ttggatgaac attatgtttt taacattgta gaatcaaaag atacaagtaa
    24061 taaagtaata ggaagtatta atgatacctt aaataagtat ccatatataa taaatgataa
    24121 aaatcttttt tatgtatcaa aattagattt agatggagtt ttattttata tattttgcga
    24181 ttcacttaat gatattttta atattaagac gtttgataaa ggacgtatat ttgtaagaat
    24241 agaagatgta catgctttta gagaaccaaa aaatcttgta gagatagcgg attatttaag
    24301 tagtaagaat ataccattta cgattgcatt aataccagca tatgtaaatc ctaaaaatca
    24361 taaggtaata actttatcag aaagccctga aattgtcaaa gcaataaaat atatgcaaga
    24421 taaaggtgga actgtgatat tgcatggata tactcatcaa tacaagaaag aagaagtttc
    24481 tggagaaggg tatgaatttt gggatggtaa aaaagatgaa cccttaaaag aaaatatgaa
    24541 gatatttgtc aaagatagag ttttgaatgg tcttagagta tgtatagaga atggaattta
    24601 tcctcttgca tttgaagcgc cacattatgc aatggaatca gagggatata aagaattaaa
    24661 aaaatatttt tctacttata tagggcaaca tcaaaataat gataaaaaat ttagcacaaa
    24721 tacatatcct tatattatta gggatacaga ggagtttaat atatttatac ccgaaaattt
    24781 aggatatata gacccagaag ataagtttac ttttcaaaat ataaaagaaa atttagataa
    24841 attatccatt gtaagaggtt ttagtggagg gttcttcttt cattcatatt taaacataga
    24901 gtatctaaaa aacacaatag aatatttaga aaaacagaat atagaattta tgaatttaag
    24961 agattttaat aattgggtaa aagttgatga aatacaaata agaaataatg gagatgaaat
    25021 tatagtcaac tatgataagg acttagatga actaactaaa agtgatacta gatttaaatc
    25081 catatccaat attagtaaag ttttaatatt catagtatct ataagtgttt taatatttgt
    25141 gattatattt atatatttta agagaataga taaaaagaaa tttttaaaat aaaggatttt
    25201 atattagaat caatatttta aaatatttta ggagaaattt atgagagatt taaatgtatc
    25261 agagtatttg ttcgtattta gtttgtttag tatatggtct ttattgctta taaatattat
    25321 tttagctatg ggtggatata tattttattt taaaaacttt gataaagaaa taaaagaaat
    25381 tgatgaatat cctatgatat caatacttgt tcctgctcat aatgaagcta aagtgatagg
    25441 tagaactgtg gagtctttgc tattactcaa ttatcctaag agtaagatgg aacttattgt
    25501 tataaatgac aattcttctg ataatagtaa agaaatttta gaaaatataa aggataggta
    25561 caacaattat aatttcacta taataaatac agatagttta acaggtggaa aaggaaagtc
    25621 taatgcatta aatattggat atacgatttc aaaaggagat tttatagctg tttatgatgc
    25681 agataacaca ccagataaaa atgcacttag atatctagta caaactatag taatgaatga
    25741 tgaattaggt gctgttattg ggaaatttag gactcgaaat aaaaataaaa acctattaac
    25801 caaatttata aatatagaaa cattaagctt tcaatggatg tcacaagctg gtagatggca
    25861 actttttaat ctatgtacaa taccaggaac taactttata ttgaggagaa gtatcataga
    25921 agaaattgga ggatgggata gtaaagcaat tgcagaagat acagaaataa gttttaggat
    25981 atataaattg ggatacaaga taaagcttgt accacaatct ataacatggg aacaagagcc
    26041 agaaactgtt aaggtgtgga taaagcaacg tactagatgg gcaaaaggga atatatatgt
    26101 attaatgaaa tatataaaaa atatatttaa acagggaaga aataagattg tgtttgatat
    26161 agcttacttt ttttctgtat attttctatt tttaacatct gtaattatat ccgatatttt
    26221 atttgtttta agtatatcta aactagtaga aatttctatt ccaattaact tttttctaat
    26281 atggatacta tcttatcttt tatttattat agaagtgagt ataagcctta ctatagaaaa
    26341 aggtgaagca acaattgaaa atatattcat agtggcaata atgtatttta catactctca
    26401 actatggctg tttgtagcta taaaaggaat gatagagtat ctaaaagata taatttttaa
    26461 aagagaggtt aaatggtata aaacagaaag attttgattc atgtacagga ggaattaaca
    26521 tgaaaaaatt tattatatca attatatctt tagtattgtt tttttcaaat atatcactta
    26581 tatacaaagt aaatgctgat gagactaaag ttaaaaatta taagtttgaa agagatataa
    26641 ctattgatgg tgttatagga agtaatagta ctttttttga agtaaataaa aattgggata
    26701 ttgaagaagt tttattgcat cttaatttta gtaagagcca aatattaaat ggagatgttt
    26761 caagtttaac tgtattgata aataatgtac caataaaatc tattaaatta aatgctaaga
    26821 caaattataa aaatacatta gaagtattag ttccaaaaga ttatataatt caaggatata
    26881 atgaaataaa aataaaaaca tacaaaacaa tatctgataa aatttgccaa gatgattcca
    26941 atactgggaa ctggatggtt attcacaaag aatcatatat atcaattaga tataagcaga
    27001 aaaaggtgga aaactcaata aatgaatatc cgtatccata tgcagaaatt gaaaataatc
    27061 ataaattaga tacaactata gtagtaccag ataatatgac tagaggagag actacagcag
    27121 tgtttaattt ggcatcagca tttggaaaaa taacaaaaaa tgatgattta aagttagatg
    27181 ttaaattata ttcagaaatg aaaaattggt cagatgataa tattatatat attggtaaac
    27241 ctgaaaatac agcagaagaa attttggata ttttaagtat aaaggaacaa accctattat
    27301 cttcaaactg tataatcaag caagtagatt caccatacaa taagaataag aagatgatgg
    27361 tggtaattgg tagtaatgaa gatgatttaa taaaggcatc aaatttatta atagaaaata
    27421 gactttctaa ccaagtttta tcatcatcag tacttgtaaa caaagagact aatataaaaa
    27481 ttaataggga acaaaaatta aatttaggtc atttaacatt aaaagattta ggatattctg
    27541 actttttgtt ggaaggagca tttaatcaac aagctttgtt tgatgtcaaa ataccaacgg
    27601 gtaaggtatt agatgatggt tcaaagatta tcttaaattt aagatattct gacaatttag
    27661 attttgaaaa atctttagtt acagtgtcta taaatgatgt tattgtggga agtaaaaaat
    27721 tggataggtc acattctaat aatgataagt tagaattaaa aatacctaaa gatatagata
    27781 ataaaaacta ttatcaagtt aaattgacat ttaatttgag tataaaaaat tcgaattgtg
    27841 ttactagaga gagtaataat ccttgggcat atgtatcaaa taattcttat ttggcgttat
    27901 ctacgaaaga aaatgaaacc ttatcttttg aaaattatcc gtatccattt gttagagatg
    27961 atgaatttaa tgatttaact gtgataatgc cagattattc agggtcacaa gctatgacct
    28021 ggatgtttag attaggtgtt actttaggtg cgaatataaa ttcacataat ggaaatataa
    28081 atgtaattag aggaaaagaa tttagtgaca agtataagga tactaatatt gtagtttttg
    28141 gagtgccaca taataattct gttataaaga tgttaaataa taatttaaat ataaagttcg
    28201 ataaaaatta ctccaatttt atatcaaatg ataagataag ctttattgat gattatggaa
    28261 aaaatatttc tactattcaa ttaataaaat caccatataa taatcaaaaa aatatcatgg
    28321 taattagttc aatgaatgaa aaaaacttat atttaggaat ggattatttg ttgaataaaa
    28381 gtaaagttaa tgatttaaaa ggagatacat tgataattga tgaatacgga gaggtagaag
    28441 atttagctta taatttaaaa tctaagaaag aagtaaaaga ttcaagttgg aatatgagta
    28501 taaataagac aactaaagta tttttaatga tttcttttat tactataatt atagtcatga
    28561 tattatcaat gctatatata aaaaaatata aaagaagata atatgataaa tttattattt
    28621 taaaagaggt atataatttg aggaaatata tgaatgaatt taaattaaaa agaagtattt
    28681 taatctcatt aataatctta atttttatat ttatagttta ctttgtaagt attgagttaa
    28741 aagataggag tctagtaaat aatcaatata aaggtaagat taaatcggcc aatttatctg
    28801 tagattatga aataaatcaa gttatgaagg atatagataa attgggattg aatacagtaa
    28861 atgtacctat aattataaat gtagagtcca ttaattctga tattatgtca atagataata
    28921 atagtaaaga aaaggcaatt aagttaataa aaaaattaaa taaaaaaggt atttcaacaa
    28981 tattagaggc atatccatgg attgaaaatg gaaaattgta tgagactgac tggaacccta
    29041 taaataaaaa aagatttttt tatacttggc aaaatgccat attaaatgaa cttataattg
    29101 atgtagcaaa tccactggat gtaaatgttt taaatattgg ttctaatttt gtacatttgg
    29161 aagaatatca acaaaattgg ggtgaaataa tagattttgt acaatccaaa tttgacggtc
    29221 ttgtaacgta cagaactaat tggtggtata caaaaaaaga tgatttaagt agtaagttgt
    29281 tttatgaaca aaagctgaac aataattttt ttgataagtt agattttata tctatagcag
    29341 catattttga gttaagtaat aaacctgtta atacagtgga tgaattaatt tctgccttac
    29401 actcatctac tgtaaacaat agaggacaaa atataaaaca agaaatatat aacctttata
    29461 aagctcatag aaaacctata ttttttggag aattaggttt ttcaaataga gaaagtgcaa
    29521 gttctcagcc gtggaatcat actccttcaa aagctgtaaa tggcgaagaa caagcaaggt
    29581 gttttgaggc atataagaaa gtttttgaaa atgaagactg gataaatggt ttttctgtgt
    29641 tttgtgtagg taaaatagat gacgaaaaaa atttttaccc atcaaaagag agtataaaag
    29701 ttattaagtc ttggtatgaa taattttgaa agtgtagaat ttatatagat taaatagatg
    29761 attaggagag atataaatga atgacatcaa ggttatgact gtatttggaa ctagacctga
    29821 agctatcaaa gtagcacctt taataaagga acttgaaaaa agagagaata taaaaagtat
    29881 tgtttgcgtt acagctcaac atagagaaat gcttgaccaa gttatagaaa cctttaatat
    29941 aaatgtagac tatgatttgg atataatgga aaaaggacaa agcctgaatg atataacatg
    30001 taagatttta aataaacttc ccttgatttt aaacaaggaa aatccaaata taatattggt
    30061 acatggagat acaaccacaa ctctagctac aagtttgact gcattttata ataaaactct
    30121 tgttggtcat atagaagctg ggcttagaac ctatgataaa tattctcctt ttccagagga
    30181 gctaaataga caacttacag gtattattgc tgatatgcac tttgctccta ctaatttggc
    30241 tagaaaaaac ttgatttctg aaggaaaacc taataataat atatttgtaa ctggtaatac
    30301 tgctattgat gctttaaaga tgacaataaa agaaaactat aatcatccta taattgatga
    30361 gattggtaac gataggatga ttttgttaac ctctcacaga agagaaaatt tgggtaaacc
    30421 tatgaaaaat atattcagag ctataaagcg aatagtagat gactttgaag atgtacagat
    30481 agtatatccc atacatttaa atcctaaaat acgaactata gctgatgaga tatttggaaa
    30541 atttcctgaa aaaattcata ttatagagcc tttagatgta gctgattttc ataacttttt
    30601 aaataaatct tatatgataa tgactgatag tggaggaata caggaagaag ctccatcatt
    30661 aggtaagcca gttcttgtgt tgcgtgataa aacagaaaga acagaaggaa ttgaagcaaa
    30721 gacacttaaa ttagtaggta ctaatgaaga tagaatatat aattcagtga gcgatttatt
    30781 aataaataaa gataactatg ttcagatgag taaagcatct aatccatatg gagatggaaa
    30841 tgcaagcaaa tatatagtgg atataataat taaaaaattt aattgcaaat atttaaatta
    30901 gataaggcct aaaacattaa ctaattgata taagatttat gataatatta agtaatacaa
    30961 tttttaaggg ggagtaatat ggctagaaaa ttaataaaaa atttgggtaa aagtaaaagt
    31021 gtaaagagag tgaaactttt atttaagaag atttttatta ctgtattcat agtagcaagt
    31081 atagttgcta tttttaatat aacgaaatat tttgaggaat tatacaaagt aagggattta
    31141 aaaagtacta aaattgaata ctatatggat gtggctgatg aagcaggaga tggaaaggtc
    31201 caattaagtt ggaaggcctt acttgctata gacatggtaa tacatgatga agatttaagt
    31261 aatataaaaa agaaagacac attggatata ggggaaaagt ttatagtaga agataaaaat
    31321 ggtaaaggcg aaaaggtgta taaggtaaaa aagtttaata aggtattaag cgaattgaaa
    31381 tttgactctt ctcaaaaaag tagagcaaga aaatacatga aagatttaga atacacatac
    31441 cttggaaata aacaattaga tagtagtgat gaaaaaatta aatttataaa gaagttagaa
    31501 gactcagcta taagagaata tattgattat ggaatattgc cctctataac aattggacaa
    31561 gctatattag aatctggttg gggaaattct aaacttacaa aacagagtaa taatttattt
    31621 ggtataaaag cagataaagc atggaaagga aaaagtgtag aaatttcaac ttcagagcat
    31681 tataatgaaa aaattgtagc tagttttagg tcgtataatt cattacaaga ttctgtcaaa
    31741 gaccacagtt tatttttaat taataataaa agatatagaa aacatgggtt gtttgaggca
    31801 aaagattata ttagtcaagc tcaagcatta gaaaatgcag gatatagtac agcagaagat
    31861 aaaaaaggaa atcgtatata tgcagagcta ttaatagatg ttattaggag ttataatttg
    31921 caattgatag ataataaagt tgagacaaaa taattgttaa ctttatatga ggagataaca
    31981 agataagatt tttttctaca aaaagaatag aaaaattgta aaaaaaacta aaaaaatgta
    32041 ttgacttgtt atttaaaagg tgatattatt attactgtac tcgaaagaga acaaaa
//
LOCUS       DAEQCW010000039        31200 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.039, whole genome shotgun sequence.
ACCESSION   DAEQCW010000039 DAEQCW010000000
VERSION     DAEQCW010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31200)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31200)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31200
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.039"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..1022)
                     /locus_tag="KRO40_001793"
     CDS             complement(<1..1022)
                     /locus_tag="KRO40_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBH2092614.1"
                     /translation="MKRVYIDFEMNMPNSKSKRAVFNSDIIAIGAVMYDEKTKNIDKF
                     KSLIRPVSNEELYPHIQELTHISSEELKSAPSYEEVMRKFKKWLGIFSDIKGIYTFGN
                     LDLTCFNNTDMRSAKKNNHPRFVNNIRDLFVDIKEKYINCGMRCMNYISLKNLLEFVN
                     LEFSGDAHDPLNDAYNLFILDEAITNNVDIQNLLIIRDIIRPPFNDINSNLDNCFNKF
                     KESLYKKEGNYNIVDFSVEIIKTVRMYLLTIIDVNIQNLEIMKDISKKMDTIDKLKDI
                     EEGYFYLLEDVYFDMKDVLEDLMLYRMNEDEYKYEIKNIIKMFDEDLDNEKIYINKCN
                     NLNVVN"
     gene            complement(1070..1930)
                     /locus_tag="KRO40_001794"
     CDS             complement(1070..1930)
                     /locus_tag="KRO40_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBH2092615.1"
                     /translation="MSELSGKGCEIIVPFEERLPVRDIEKSIIKKYRKNLWSKFMKAI
                     RDYKLVEEGDKIAVAISGGKDSILMAKMFQELKKHGQVNFDVEFIAMDPGYHANIRQL
                     LIDNCEYLNIPIHLFDSRIFEIADEIAKDYPCYMCARMRRGALYSKAEELGCNKLALG
                     HHYDDVIETTMLNLLCAGNFKTMLPKLNSTNFEGIKIIRPLYYIREEHIIRFIQNSGI
                     WPLNCACMVAAKKTGNKRYEIKDLIKSLESNFKNVEKSIFKAAENVNLDSVLGWQKDG
                     EKHSFLENFE"
     gene            2199..2408
                     /locus_tag="KRO40_001795"
     CDS             2199..2408
                     /locus_tag="KRO40_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBH2092616.1"
                     /translation="MENKTRDIKKNCGPSLARPYINNQIFTEMYCLSDALKFGTIFPE
                     LNLLESEMYNKELYAKPKKYRGGRR"
     gene            2408..2674
                     /locus_tag="KRO40_001796"
     CDS             2408..2674
                     /locus_tag="KRO40_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBH2092617.1"
                     /translation="MKDSSRAELMRKVQETSFACVDMNLYLDNHPDDKNAINTYNSLC
                     NQFAQARYAYENKYGPLTNFGYAPSRCPWQWADQPWPWDREFNY"
     gene            2703..3275
                     /locus_tag="KRO40_001797"
     CDS             2703..3275
                     /locus_tag="KRO40_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000265278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH2092618.1"
                     /translation="MWIYQKTIQHPVNIKTCDPRMAKFLITQFGGPNGELAASLRYLS
                     QRYTMPTGNMRALLTDIGTEELAHVELICTMVYQLTSDASPEELKAAGLGSNYAQNGY
                     GIYPTDSNGVPFDVRPIAVMSNPVTDLHEDMAAEQKALATYYQLINLTDDVDVIDVLK
                     FLGQREIIHYQRFGEALMDAYELEESQKMF"
     gene            complement(3510..4700)
                     /locus_tag="KRO40_001798"
     CDS             complement(3510..4700)
                     /locus_tag="KRO40_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH2092619.1"
                     /translation="MNFNQKRIAASIMATAIIMPTMGNLAYANESEVESVSIESRTIT
                     GNAVNFRKGPGTNHESMGKLYKGDKVEYVGKEGSWVKVKYNGNTGYVHGNYVAINSLG
                     SSNESSDTSVKSTKVVTAKGLNFRTGPSTSSSKISTLGYGTEVGYISESNGWSKISSN
                     GRVGYVSSKYLGTSVNDSTNENSENSSNDLVKGTKVVTAKSLNVRTGPGTSHSKIATL
                     SYGTEVGSISESGGWTKISYGNQTGYVSSQYLAEKGSVDTSIPSYSTNSPSQGADSVI
                     SFAKTLLGKPYVWGAEGPNSFDCSGFTQYVMKKSVGVSIPRVSRDQSKYGTYVNRGDL
                     RSGDLVFFDTQGSNNGSVSHVGIYIGNGDMIHASSGSSKKVTISNINSSYYSSRYVNA
                     RRVL"
     gene            complement(4960..5391)
                     /gene="dut"
                     /locus_tag="KRO40_001799"
     CDS             complement(4960..5391)
                     /gene="dut"
                     /locus_tag="KRO40_001799"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HBH2092620.1"
                     /translation="MYNLKVKKLNDDAIIPNFAHKGDAGMDLYSIEEVVIPPGETKLI
                     KTGICIELPTMTEAQVRPRSGLALKHSVTVLNTPGTIDEGYRGELKIILINHGKNDFK
                     VEKHMKIAQMIVKPIYDINIEEVKELSDSERGKGGFGSTGF"
     gene            5504..7732
                     /locus_tag="KRO40_001800"
     CDS             5504..7732
                     /locus_tag="KRO40_001800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IA DNA topoisomerase"
                     /protein_id="HBH2092621.1"
                     /translation="MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLV
                     SLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVI
                     NATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAA
                     GYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYY
                     EIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAP
                     KLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASK
                     ASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDA
                     IKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVN
                     KDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATR
                     ADVLKKISQVGYVKKKGKSYSITDLGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGK
                     YTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNT
                     EKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKND
                     KYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEF
                     DN"
     gene            complement(7843..8328)
                     /locus_tag="KRO40_001801"
     CDS             complement(7843..8328)
                     /locus_tag="KRO40_001801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2092622.1"
                     /translation="MDNNNILKIADSFLDFLFVLENNIFKESDLLKKFQNNSDIMKAY
                     FEECPMAPSHAKVILYLMTSNSSSISQIASNLGILKSNMTPIIDRLVEHGLVNKFPDP
                     KDRRILRVELTDKAFKLFDAVKAILKESLVKKLSNLSEEELTLLDEHTLKLSEIVKKL
                     G"
     gene            8580..9803
                     /locus_tag="KRO40_001802"
     CDS             8580..9803
                     /locus_tag="KRO40_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBH2092623.1"
                     /translation="MKRYLIVFLMCSSLFLVGCGKTEESEPEKPIAVSVQKAIGGEIE
                     NTNSFSGTTKVKDETAVTAQTVGTVQEVYVKLGQNVRKGDELLSISSPELENSVKQSK
                     ASLDLAKASYSSATGGSLEAQVNQAKTALDNAKIQYEESQRNYDNNKILYEQEVISLD
                     QFKKIEFSLEQTKQQLDSAQRAYDTATSKSIPQAKALAKKQLDQAQVSYNLAMSNLDK
                     LTLTSPVDGTITAKNFDSKEMITQSQPAFIISNPNILEVDLNVAESDIGKFKKDGNVD
                     VIIEDQRILGKIDYVPSVVDPQTSLYPVKVLVNNTNNKFKAGMSAQVNLSVEKENGAV
                     TVPKKAIFEENGKKYVYIATKDNIAKKHLVQTGIVTEDKIEIKSGVSDKDTVIIGGIS
                     LISDGTKIFPVEKEK"
     gene            9807..12941
                     /locus_tag="KRO40_001803"
     CDS             9807..12941
                     /locus_tag="KRO40_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter permease subunit"
                     /protein_id="HBH2092624.1"
                     /translation="MNLTQTSVKRPLTIIMVFLVLIVFGGIGYKKMSINLMPDIEIPV
                     VMVMTTWTGAGPQDVDEQVSQKVDESLSAVSNVKSTISSSQESVSMVVAQFEFGTNLD
                     EIMNDVRSKVDALQTSLPDDAAKPTVLKLDMNAQAIGQLVISGGNENSSQALRKYAED
                     VIQPKIESIDGVTSADLKGGEKAQVNVIADPAVLSNYGVSLSTIKGVLSSSNKTFPYG
                     SITQGEDKIVLRAIDKLESLDDIKQIQIPVKGGNTVRLDNLCSVDYGYADKDSIYRYN
                     GKDSLVIDISKQQDANTVKVMQSAYKYVDELNKENPQFKIKIANDTSSYISESINSVM
                     SNLLISAVIAFIVIFAFLKSVRASLVVAVAIPISIIGAIAILYFTGESLNLITASSLV
                     ISVGMVVDNATVVIENIFKYRKSGRLSLDDCAIEGTRTVTNAILASTLTTIAIFLPIM
                     FTEGIAKITFGALGKTLIASLAFSFIGAITLVPSVFAKLSRGKNSQKMQEKDSPIFDK
                     VSEAYKKLLSVCLRHQRLVVISSLLIFVASLFGMGFIGMDFMPAADKGELSISIELPK
                     GLSLESNDYYVSMTEKKVSDIPEIKTLITTLTSDSNNSKASIAIELESQKNRKRTTDE
                     IEKEIIDRVATVPDCKINVSQNSSVMGGAGGADFTLEMKGPDLDVLKILGKEAEKEFS
                     SIKGFRNVETSLTDTTQEAQFTIDKHKAQEYGVNTAEIAGMLRTAINGDSVTTATIDD
                     YKVDVNLKFKADTIDSLEDIKQLKVNSATGKEVPLGAFSDIKMADGLQSISRTDGDFS
                     VNITATLDNLDAGTATKLALEKTNKMVIPKDYSIGVGGETEMMNESMASLGFSMVIAI
                     ALVYMVMVAQFESFSKPFIIMFCVPFAFVGVVLSLLVSGQSLSTVGMLGIILLIGIVV
                     NNGIVLIDYIEQLRKTNRNNDLIGLVSIGCAARLRPVLMTTATTILGMLPTALSLGEG
                     GETMQPLAIVIMGGLTVSTLITLVLIPTIYLIFDKWENKFSDKMPKIFGKITDKIGSI
                     KRKIIKKPKLKAKV"
     gene            12975..14273
                     /locus_tag="KRO40_001804"
     CDS             12975..14273
                     /locus_tag="KRO40_001804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TolC family protein"
                     /protein_id="HBH2092625.1"
                     /translation="MSKIVAIGCGVGIITANLIPVYADNNTSSINKVDNSILSDSNKR
                     TSEKEILTAREAVSAALKNSEKLKMKSEEIKMLKEKLEVQDEFDSFTGSDNSFPYDQI
                     GLLKNQSEQAKGFMEDQIANDITNKFNDLVSRENELDKIKNNLEIKTKEIKDMKLKKD
                     LGLVTSLETESAELELQTLQNTQKAKLQELKNNQDYFKLLTNIDLNNYQLDKEYRFES
                     FRVGGSVDSYMEGKVNEYLKYDQLILERTEESFNDKDENKADLPDRPNLTRPVAPTKP
                     EQGNLTDDEYKVLMDKYEKDYDRYKKEVEAYNLERQTYAAGLTTYANYLQQKFNTENG
                     LVTLEDSKKALKKGLIDSYAQLLALEDTIQITKKQLDLSEKQLKNTKLRYDLGLITLT
                     DYKKQVVSNEDAKNSYDSLIVNYNSLKNGIEKPWILNTGK"
     gene            complement(14562..14807)
                     /locus_tag="KRO40_001805"
     CDS             complement(14562..14807)
                     /locus_tag="KRO40_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH2092626.1"
                     /translation="MTKCPKCGKEVSSRPGSICPRCGFKVADESLKIRCPEPSCRALV
                     SRKLDYCPKCGCKLRGYNISEFVNMVRCKIDETFDKK"
     gene            complement(15021..17648)
                     /locus_tag="KRO40_001806"
     CDS             complement(15021..17648)
                     /locus_tag="KRO40_001806"
                     /EC_number="2.7.9.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBH2092627.1"
                     /translation="METKYVYSFGEGSKDMKSLLGGKGANLAEMTKIGLPVPPGFTIT
                     TEACNDYYVNNESIRAEIIKEIEEHLATLEKDLNKTLGCNKNPLLVSVRSGAVFSMPG
                     MMDTILNLGLNDNSVVGLAEATQNERFAYDSYRRFIQMFSDVAMEVPKYKFENVLDRV
                     KEAKGYTVDTELTTDDLKEIVKEFKAIYKKEIKNDFPQDPKEQLMLAIEAVFRSWNNP
                     RAIVYRKLNDIAHNLGTAVNIQSMVFGNMGETSGTGVAFTRNPATGENKLFGEFLMNA
                     QGEDVVAGIRTPQNISTLADVMPAVFDEFVKITHILEGHYKDMQDIEFTIENERLYIL
                     QTRNGKRTAAAAINVAVDLVEAGIIDEKEAIMRIEPNQLDQLLHPKFEDKALKEAKVI
                     AKGLPASPGAASGKVYFNADDVVKANEKGEKVVLVRLETSPEDIEGMVKAEGILTARG
                     GMTSHAAVVARGMGKCCVAGCGEIKVDEFNKEIRALDDVVIKEGEYISIDGSTGNVYL
                     GDVKKTEVSLTGNFEKLMNWVDKHKCMMVRTNADNPRDARAAIEFGAEGIGLCRTEHM
                     FFDEARLPAVREMILSNTVEQREKALEKILPMQREDFVELFKVMDGKPVNIRLLDPPL
                     HEFLPHDDETIEELSKSMGIKVSDIKKRIVDLDEFNPMLGHRGCRLAITYPEICVMQS
                     KAIIQGAIEAIKAGVKVSPEIMVPLVGEVNELKIIRKMIVETVDAIIKEEGIEVPYTV
                     GTMIEIPRACLTADEIAQEADFFSFGTNDLTQMAFGYSRDDAGKFLGQYVDEEILEKD
                     PFQVLDQNGVGKLVKMGAKLGREVKPELKLGICGEHGGEPSSVEFCYSVGLNYVSCSP
                     FRVPIARLAAAQASIKNPR"
     gene            complement(17709..18551)
                     /locus_tag="KRO40_001807"
     CDS             complement(17709..18551)
                     /locus_tag="KRO40_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase/pyrophosphorylase"
                     /protein_id="HBH2092628.1"
                     /translation="MLVKNLIIYAVSDSVGETAQQVAKACMSQFYVNETYEIKRFPYM
                     INKGVLLETLENAKAENALIVYTLVDEELCSIVERYCEREGLSCIDLMTDILREISKR
                     TGRKPKREAGIIRKLDESYFKRVEAIEFAVKYDDGKDPRGVLQADIILVGISRTSKTP
                     LSMYLANKNIKVANVPLVPEIPIPKEVFEIDTKKIIGLTNSPEKLNEIRTQRLKALGL
                     SSKANYANLERILQELDYSEEIMKRIGCPVINVSNKAIEETAGIILDIMKENGLKIYK
                     EIEI"
     gene            complement(18558..19196)
                     /locus_tag="KRO40_001808"
     CDS             complement(18558..19196)
                     /locus_tag="KRO40_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092629.1"
                     /translation="MIIIQLNERQLKIIDIVKENEPITSESIASSLNVTRATLRSDLA
                     ILTMTGILDARPKVGYFYSGVSEINLIGKSVKEKTVEDIMSMPVLAKKDESIYDVIVT
                     MFLSDVGSIVIIDENEELCGVVSRKDLLKATIGGSDINKMPIGMIMTRTPNVVTLTKG
                     ASVLLASRKIIEHEVDSIPIVEYKGEDKNHMRVVGRISKTNITKLFLEIVDN"
     gene            complement(19632..20924)
                     /locus_tag="KRO40_001809"
     CDS             complement(19632..20924)
                     /locus_tag="KRO40_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HBH2092630.1"
                     /translation="MLDLNRKLAKLEEEGKKIKVALIGAGHMGNGMVSQMANMKGIEA
                     SIVVDINLELAHKAFTDAGIDEEIIDNVTNEKDAEIKLQEGKVLTCNDFLVACKTKSI
                     DVVIDATGGIAIGAEIALNSILNKKHIVMLNAETDCVVGPILKKLADDAGVIFTGSAG
                     DEPGAVMELFDFADAMGFEVRVIGKGKNNKLDLDCNPDTVREEAERKGASPHMIASFK
                     EGTKTMVEMALMCNATGFVPDVRGGHGIEATVNEVPKKYALKSEGGVLDNYGVVDFVN
                     GIAPGVFVVVAHKLKAVNDELKYLSMGDGPNYILYRPYHLCSLETPLSAAMAVLDHKA
                     TIVPKAGLVAEVMTIAKKDLKKGEFMDGYGAYTCYGTIEKYDVAKAMNAVPIGLISKK
                     TKVVKDIKKGEVITYDMVEIEKDTTLYHLRQLQEKIFG"
     gene            complement(20961..21317)
                     /locus_tag="KRO40_001810"
     CDS             complement(20961..21317)
                     /locus_tag="KRO40_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBH2092631.1"
                     /translation="MKYEVKISGIGSLVKELMDESNCLIIYDETINDDDLKDISVIHS
                     IATLKSDVEIGDTLTIGNRDYCIVSVGDIAQKTLREIGHCTIKFDGKCEVNLPGEIHV
                     EIGNPDITIGDLITIS"
     gene            complement(21352..21711)
                     /locus_tag="KRO40_001811"
     CDS             complement(21352..21711)
                     /locus_tag="KRO40_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092632.1"
                     /translation="MKLLVILFVAYILNTIFIMKQNKLYFKTLNRAKKKGDIVSTGKK
                     KSYFSKGSIAIISSDSDGFIKFGEILKGRTVMAKFKEIEEIEGLDIYSAEQKFKDEES
                     IVQAIKFIKEKINVSFN"
     gene            complement(21780..23753)
                     /locus_tag="KRO40_001812"
     CDS             complement(21780..23753)
                     /locus_tag="KRO40_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH2092633.1"
                     /translation="MSVTEKIPSIDRKIFKILIMCSKKEFVSINSIANELNVTTRSVR
                     TYIKQLNKDLGNDIAVIKYIKGQGYKLEIKDEQILNKIIDMNRKNVFSLNSKEDRVEF
                     ILNYLIELDGFITLDSLADEMCVGRTTLVNDFQYVEKVLASYNLNLIKKQNTGMKLNG
                     NELDIRLFILNQLYKNSRKDLSNSKYFKGIKKEEIINLEEKLLTLFKKNNFYVTDEML
                     REVINYIVVLVYRVKEEKKVKDYDVKFDLLKSYDEYFIAREIKHIISGMFECTLNDEE
                     IIYLTIPLVSGNAPASECALNSSRISKNIDELMENIFNQIYVDMGIFINEDELRVGLG
                     YHLSFTLNRLLFNIKLKNVLLEEIKQNCILPFKLAQIAGKVIEKKYNLEVSEDEIGYI
                     AIHFSGYLERNSSRFYSIKKIAIICSTGLGTAKLLKIRVEKLIGNNPKIDTLSSFNLR
                     NINLDEYDIVFTTIDLDTSNINTIVLKINTIFDENKLREQLKTVLCLREGNIDTTNST
                     NLLINNLLDEDKFMILNEKTILASLEKMMDHLMDLGCIDEKFRKNIVNREEKSPTVFD
                     KGLLFPHSINEKSDKFLMAVGILEEPIEYANRSIKIILMTMFPCENKIDSDLLVKIYE
                     EVLKIGQDVKLTNKISKCRTFLEFKKVLLKNLI"
     gene            complement(23975..24988)
                     /locus_tag="KRO40_001813"
     CDS             complement(23975..24988)
                     /locus_tag="KRO40_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBH2092634.1"
                     /translation="MEENKILKIEKGTSGWGGPLYIKKEGNRNKILSMTAGGIHEVTL
                     KIKELLGCEIVDGFKTGVSDEEVAVVIIDCGGTARCGVYPKKKIPTINVNPVGKTGPL
                     AKFITEEYYVSDVNPNCISVVDGEDMPQKSQENKSENKSSIRKPDNYDEVKSKAQGEY
                     AKKNIILSIGQGAGQVVSKFYDAGRDTIQMVMNNVIPFMAFVSMLMGIILASGLGDWI
                     ARVISPLAGNIGGLLIISVICTLPFLSPILGPGAVIAQVVGTLVGTQIGLGAIPAYLA
                     LPALFAINGQAGCDFVPVGLSLGEAEPETVEYGVPALFYSRLITGPIAVIIAYGVAVF
                     ALR"
     gene            complement(25001..25546)
                     /locus_tag="KRO40_001814"
     CDS             complement(25001..25546)
                     /locus_tag="KRO40_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBH2092635.1"
                     /translation="MENVITGLSKGAEWFIGLFQKGGEQFIGLVSGTLPTLIVLMVAI
                     NSLIKIIGEERVNNWASKLGKNSFTRYILLPLVSVFFLGNPMCYTFGRFLKEEHKAGF
                     YDAAVSFVHPITGLFPHANAGELFVWLGISAGLTTLGKETTTLALWYFIVGLIVIFIR
                     GIVTEKMYAFLTRKNRATNKA"
     gene            complement(25922..26791)
                     /locus_tag="KRO40_001815"
     CDS             complement(25922..26791)
                     /locus_tag="KRO40_001815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2092636.1"
                     /translation="MDYLKYFEKAVMYIENNLHENITVNDVAKETGYSYYHLTRLFKS
                     MFGESVGSYIKKRRLVSSTKELLYSDKKVIDIAIGSGFESSEAFSRAFKSIYKVSPIE
                     YRKNRIDVFVGKKKKLELDFMRHLVGNITIKPVIKEIEKIKVIGIKDKVILENNSLPD
                     LWEKFRKVHHIVPNTLPSKRVFGICEAISEIHLVSESMEFNEIIGLEVNSYDVIPNSF
                     VSKTIKEGKYAIFTHTGSLDNLDKTYEYIWGTWLLSSKEELDIRDDFEVYDERFLGPS
                     NVNSQIDIYIPIK"
     gene            complement(26943..28058)
                     /locus_tag="KRO40_001816"
     CDS             complement(26943..28058)
                     /locus_tag="KRO40_001816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="linear amide C-N hydrolase"
                     /protein_id="HBH2092637.1"
                     /translation="METLEVRNIELSGTNYEIGYRLGELVANMPEIIEGQINKSNLVS
                     KKEEKEMIELFDKYCPGLNEELQGFADAIQVNCNQILYYTMTYLKPGCSQVALAPELT
                     ENGHVLFARNFDFSHNMEDFVLCKTKVNGKYAHIGTTIMQFGRGEGMNECGLGVSQSS
                     CGIPVGNSDGLRKPAIVGLQFWAVIRYLLENCKDVDEALEYLKDMPIAYNINLLLADK
                     SGNIALVETLDGKKEVNIINSLESKREYFLHSTNHTHIDKLHKLDPQSMKNSIHRYKL
                     IKEYINKSKKIGEKELMNLLSSKYPNGLSCNYYNDFFGTLKSIVMDLNIGKFNILWGG
                     LENKWESYYLKNDIKSITQRININIEKAPSDFFDFIE"
     gene            complement(28294..29430)
                     /locus_tag="KRO40_001817"
     CDS             complement(28294..29430)
                     /locus_tag="KRO40_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2092638.1"
                     /translation="MKERIIQVADSKKEKILGLCQSLYDEPEIALQEYKSAKKISEFL
                     REEGFDVEENLAGMATAFKATKKNGDGPKIAFIAEYDALPGNGHACGHHLIASMGVGA
                     GIALSSILDTYKGEVSIIGTPAEETGDGKPYLIEHGVFDGYDAAMMIHPNSKTCVTPE
                     IIAIGGLDFIFTGKASHAGAKPYNGINALDAVVLLYNNINALRQQLVDGTRIHGIILE
                     AGTAANVIPDMGKVRLEIRAKEQNYFDEVVEKVKNCARGAAIATGCELEFYHFEPTCQ
                     GLNENKVLVDIFTKIMEEFGIYEDEQVMLGSTDMGNLSQIMPCIHPLMKFSENGEELH
                     TKEFLEASINSYAKDRVIDGIKILALTGFNLFENPELLKKMKEE"
     gene            complement(29486..30949)
                     /locus_tag="KRO40_001818"
     CDS             complement(29486..30949)
                     /locus_tag="KRO40_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBH2092639.1"
                     /translation="MTDLVNTINGIVWSPVLVAMCLCIGLYFSLKLKFFQIRDVKEMF
                     TLLLEGDSSHVGISSFQGFATSMAGRIGTGNIAGVAVAIAMGGPGALVWMCIMATLGS
                     ATAFVESTLAQIYKDEHDGQYRGGPPYYFEKGLGWKKCSVLFSIVAIISYTFFMPGTQ
                     SNTLYLAMNQAFGFSKMTIAVASSIALAIIIFGGIKRIGLFAEKVVPIMGGAYLIMTL
                     VIIITNISLVPEAIVTMFKSAFGFGSVFGGMLGSAISWGVKRGIYSNEAGEGSGTYGA
                     AAAEVSHPAKQGLVQAFSVYVDTLLICMATGIMIVITGMYNVTGVCTALPGVEPGPQY
                     VQSAINTLHTQLGDIFIAIVLLLFTFTTLLAFSYMMETNVSYLVTRIKAEKHEKYIIN
                     VCRFMLIACAAMCCFIEPLTSWALGDICIGVLTYINLIAIFTLKKPAIKAYYDYIRQK
                     KMGIKRSDRTFNPIELDIRNAEFWENRYLKEDKHELN"
BASE COUNT        10592 a         5292 c         3826 g        11490 t
ORIGIN      
        1 ttattaacaa catttaagtt attacattta tttatatata ttttttcatt atctaagtct
       61 tcatcaaaca tttttattat attttttatc tcatacttgt actcatcttc attcattcta
      121 taaagcatta aatcttctag tacatctttc atatcgaagt acacatcttc taataaataa
      181 aaatagcctt cctctatatc tttcaattta tctatagtat ccattttttt acttatatct
      241 ttcataattt ctaaattttg tatatttaca tctatgattg ttaataagta cattctcaca
      301 gtttttatta tttcaacaga aaaatctaca atattataat ttccttcttt tttatataat
      361 gactccttaa atttgttaaa acaattatct aaattagaat ttatatcgtt aaatggtggt
      421 cttattatgt cacgtattat taaaagattt tgtatatcta cattatttgt gattgcctca
      481 tccaaaataa ataaattata tgcatcattt aatgggtcat gggcatctcc actaaactct
      541 aagttaacaa attcaagtaa atttttcaat gatatatagt tcatacatct cataccacaa
      601 tttatatatt tttcttttat atctacaaat aaatctctaa tgttatttac aaaccttgga
      661 tggttatttt ttttagcact tctcatatct gtgttattga aacatgtcaa atccaaatta
      721 ccaaaagtat atattccttt aatatcagaa aatatgccaa gccatttttt aaactttctc
      781 atgacctctt cataacttgg tgcactcttc aattcttcag aagatatatg tgttaattct
      841 tgtatatgag gatacaactc ctcattactt actggtctta ttaaagattt aaatttatca
      901 atattttttg ttttttcatc atacataact gctccgattg caattatatc agaattaaat
      961 actgctcttt ttgatttaga atttggcata ttcatttcaa aatctatata tactcttttc
     1021 aatataaaca ccctttccaa ttgtttatag tgattctttt taactatttt tattcaaaat
     1081 tttctaagaa agaatgtttc tccccatctt tttgccaacc aagtactgaa tcaagattta
     1141 cattttctgc cgccttaaat atagattttt ctacattttt aaaatttgat tctaagctct
     1201 ttattaagtc ttttatctca tatcttttat tacctgtttt tttagcagca accatacatg
     1261 cacaatttaa tggccatata ccactatttt gaataaatct tataatatgt tcttctctta
     1321 tataataaag tggtcttata atttttatac cttcaaaatt agtagaatta agtttaggaa
     1381 gcattgtttt aaaatttcca gcacacaata aattaagcat tgttgtctct attacatcgt
     1441 cataatgatg acctaatgca agtttgttac accctaattc ttctgccttt gaatataatg
     1501 ctcctctcct cattcttgca cacatatagc atggataatc ttttgctatt tcatctgcta
     1561 tctcaaatat ccttgaatca aataaatgta ttggtatatt tagatactca caattatcta
     1621 taagtaattg tcttatattt gcatgatatc cagggtccat agcaataaat tcaacatcaa
     1681 aattaacttg tccatgtttt tttaactctt gaaacatttt agccataaga atactgtctt
     1741 ttccaccaga aatcgctaca gctatcttat caccttcttc aaccaattta taatctctta
     1801 ttgccttcat aaacttagac cataaatttt tcctatattt ttttattata cttttttcta
     1861 tatctcttac tggaagtctt tcctcaaaag gaactataat ttcacagcct tttcctgata
     1921 gttcactcat ctaatcacct cgtatattta tgttaataat attttacaaa aaagtctacc
     1981 ttcatccaca aaatactata atttttactt taattttact aaataattta tagtttacaa
     2041 taacacataa acttataata acataaataa cctctttctt ttattatctt ttttattttt
     2101 ctcatttaat attttattat tagtaacgat ttttaaatga ttgaatatta tacactagat
     2161 agagttacct atctatttac aacaaggagg ttttcatctt ggaaaataag actagagata
     2221 tcaaaaaaaa ttgtggtcca tctttggcta gaccatacat taataatcaa attttcacag
     2281 aaatgtactg cctttctgat gcattaaaat ttggaactat atttccagaa ctaaacttac
     2341 tagagtctga aatgtacaac aaagaattat atgctaagcc aaaaaaatat agaggaggta
     2401 gaagataatg aaagactcat ctagagctga acttatgaga aaagttcagg aaacatcttt
     2461 tgcatgtgtt gatatgaact tatatttaga caatcaccct gatgataaaa atgctatcaa
     2521 cacttataat tcattatgta atcaatttgc gcaagctaga tatgcttacg aaaataaata
     2581 cggtccttta actaactttg ggtatgctcc aagtagatgc ccttggcaat gggctgacca
     2641 accttggcct tgggacagag aatttaatta ttagacatca agtattggag gattgaaaat
     2701 tcatgtggat atatcagaaa actatacaac acccagttaa tataaaaact tgtgacccta
     2761 gaatggctaa atttcttata actcaatttg gtgggccaaa tggagaactt gctgcatctt
     2821 taagatattt aagccaaaga tatacaatgc ctactggtaa tatgcgtgca cttttaacag
     2881 atattggtac agaagaacta gctcacgttg agcttatatg tactatggtt tatcagttaa
     2941 cttctgatgc aagcccagaa gagttaaaag ctgcaggtct tggttcaaac tatgctcaaa
     3001 atggatatgg aatttatcca acagattcaa atggtgttcc atttgatgta agacctatag
     3061 cagttatgtc aaatcccgta accgatttac atgaggatat ggcagctgaa caaaaagcac
     3121 ttgcaactta ttatcaactt ataaacctaa cagatgacgt tgatgttata gatgtattaa
     3181 aattcttggg tcaaagagaa ataattcatt atcaaagatt tggtgaagcc ttaatggatg
     3241 cttacgagtt agaagaatct caaaaaatgt tctaaaattt ttatttgtat aactattatt
     3301 atttgataat ttataattta ctgttgtgtt aaaatttata aaaaatataa atataattta
     3361 ttttctataa acagagaaaa taaataaaaa gcaggtatca atcaaatagt aacatgtatt
     3421 atactataca ttactatcaa tattgtacct gctttcatat tataagcaat aaagaaaaat
     3481 ctatttatta ggttttataa taaaaacaat tataaaactc ttcttgcatt tacatatcta
     3541 cttgaatagt agctactatt tatattagat attgttactt tttttgatga acctgaagat
     3601 gcatgtatca tatctccatt tcctatgtat attccaacat gacttacaga accattattt
     3661 gaaccttgtg tatcaaagaa tactaaatct ccacttctaa ggtctcctct atttacatat
     3721 gttccatact tactttggtc tctagatact cttggtatac taactcctac agattttttc
     3781 ataacgtact gcgtgaatcc agaacagtca aaactatttg gaccttctgc tccccataca
     3841 tatggttttc caagtagtgt ctttgcaaaa cttattacac tatcagctcc ttgacttgga
     3901 gaattagtcg aataagatgg aattgaagta tcaacagaac ctttttcagc aaggtattga
     3961 cttgacacat atccagtttg attgccataa cttatttttg tccatcctcc actttcagaa
     4021 atacttccaa cctcagtacc ataacttaat gtagctattt tagaatgact tgtacctggt
     4081 cctgttctaa cgttcaatga ctttgctgtt acaacctttg taccctttac aaggtcattt
     4141 gaactgtttt cagaattttc atttgtagag tcatttacac tagttcctaa atatttactt
     4201 gaaacataac ctactctacc attagaactt atttttgacc atccatttga ctcagatatg
     4261 tatccgactt cagtcccata tcctagtgtt gatattttag aactacttgt acttggtcct
     4321 gttctaaaat ttaatccttt tgctgttaca acttttgtcg acttaactga agtatcacta
     4381 ctttcattgc tacttccaag gctatttatt gctacataat ttccatgcac ataacctgtg
     4441 tttccattat atttaacttt tacccaagaa ccttcttttc ctacgtactc aactttatca
     4501 cctttgtaaa gtttccccat tgattcatgg tttgtacctg gtccttttct aaaatttacc
     4561 gcattccctg ttattgttct gctttctata ctcacactct ctacttcaga ctcattagca
     4621 tatgctaaat tccccatagt aggcattatt atcgcagttg ccattatact ggctgctatt
     4681 ctcttttgat taaaattcat aactttccac tcatctcctc ttttctacta tctttatttc
     4741 acttcaaaat ataaaagaaa taattgacac tatcaaaata tcaattattt cttttatatt
     4801 aatattatta caaatttgta actatttgtc tatagtaata tttgcttacc ataaattacc
     4861 atgtataaat tttaatcttt aatagcctgt aatttagtaa tatagccatc ttttaccttt
     4921 tttaaaaatg gctatatttt ttaacttttt tgtaactttt taaaatccag ttgagccaaa
     4981 cccacctttt cctctttcgg agtcacttaa ttcttttact tcttctatgt taatatcata
     5041 gataggtttt actatcattt gagcaatttt catatgcttt tcaaccttaa aatcattttt
     5101 accatgattt attaatataa ttttaagctc tcctctgtat ccttcgtcaa tagttcctgg
     5161 tgtatttaat acagtaacag aatgctttaa ggcaagccca cttctaggtc ttacctgcgc
     5221 ttctgtcata gtaggaagct ctatacatat cccagttttg ataagtttag tctctccagg
     5281 aggtattaca acctcttcta tagaatacaa atccatacca gcatcacctt tgtgagcaaa
     5341 attaggtatt atagcatcat catttaattt ttttactttt aaattgtaca tcttatatct
     5401 cctttcaact ttctataaat attataactt aaatttcgac ctcttgaagt tttttatttt
     5461 tttgtggtaa tataattatt agtgttttaa aggaggattt tttatgaaac ttgtacttgc
     5521 tgagaaacca tctgtggcaa aaactatagc atcattttta ggtgcaaaga ccagacaaga
     5581 tggttacttt gaaggaaatg attatataat tacttatgca gttggacact tagtatcatt
     5641 atatgatatg aaggattatg ataaagataa atactctggc tcttggaaaa tgaacaattt
     5701 cccatttgtt cctgaggata agtttaaatt taagattgat agttctaaaa ctaaacaatt
     5761 caacactgta aaaaagcttt tgaatagaaa agatgtagaa tatgtaataa atgccactga
     5821 taatgaccga gaaggagaac ttatagcatt tttaatattt ttactggcaa aaaataaaaa
     5881 accagtaaaa agaatcttgg taaatgaatg gacaccagaa gatattacaa gaggtataaa
     5941 aaacctaaaa gatgaagatg aaatgagaaa tcttcaagct gctggatata ctaggcttat
     6001 tactgactgg ttgattggaa taaatttcac ttctgttgct acattgaaat acggaaatgg
     6061 gaaactatta aacataggta gggtaattct tccaacagtt aaattagtct atgatagaga
     6121 tatggaaata ctaaactttg ttcctaaaac ttattatgaa atagaagggc attttaaagc
     6181 tgaagctggt gaatataaag gtaaatatgt taagggtaaa gaaagtaaat ttgatacact
     6241 tgaagatgca aataaaatta tagcttcaat tacatctgaa actggtaaaa tactagataa
     6301 aaaagttact atgtcaaagg aatatgcacc aaaacttttt agtttgacat cacttcaagg
     6361 atatataact tctaagtatt ccaattttac atctgataag gttttaaatg tctgtcaatc
     6421 tctctatgag ggtaatggta agggtggata cataacttac cctagaactg attccatttt
     6481 cttagaagaa agtttggctt caaaagcttc tcaaacttta gataaattaa aggttggtct
     6541 tgaatatgaa aataaaatta aattttctaa aactaaaaga gtttttgatt cttctaaagt
     6601 agactcccat agtgctataa ttccaactta tataattcca aaaagtttat ctaaggatga
     6661 acaattagtt tatgatgcca taaaagatag atttgtagca aactttatgc ctcctgctga
     6721 atatgagaat acagaaatta agactgaagt agataattgt actttcttaa caaaaggtaa
     6781 ggtgcttaaa tcaaaaggat accttgaggt atataataag gaagaaaaaa acgatttact
     6841 tccacttgta aataaagatg atgttgtaga tgtgttagaa ataaaaccat taactaagca
     6901 aactactcca cctaaaccgt atactgagga cacactttta aaggctatga aaaattgtgg
     6961 taaaaatgtg cctgaagaag atacaacagt gctatctgga tattcgattg gaacatcagc
     7021 cacacgtgct gatgtgttaa agaagataag tcaagtgggc tatgtaaaga aaaaaggtaa
     7081 atcttattct ataacagacc ttgggaaaaa tttagttgaa atttttcctg ttaaagactt
     7141 atttgatgta gattatactg gaaaacttga aaaaagttta agcgatattc aaaaaggaaa
     7201 gtatacaaga aaagaatatc ttactaatat cattagtttt atatatcaaa atgtcaatat
     7261 tataaaacaa gatgcttcaa aaaatataaa cacagaagca tatactttcg attcaaaaac
     7321 taaaaaattt actaaaacaa aagaaaaaaa acagaaaaaa gatgtaacta atactgaaaa
     7381 agaagttgct atatcaaagg attctaataa caaaaaagaa gttaaaaatg gtgatgaaaa
     7441 tcaatctctt ggcaaatgcc ccatttgtca aggtgatgta ctagaatttg acaaaggctt
     7501 tgcttgtaaa aatcataaag aatgtaaatt tgttatttgg aaaaatgata agtatttaag
     7561 tctttataaa aagaaagtta acaaaacaat ggtcaaaaat attttaaaaa aaggtgaaac
     7621 taaagtaaaa tctttaactg ctaaaaacgg taataaattt gatgctacat taaaatatga
     7681 taaaaatcca gatactggct atttcaattg gaaaatagag tttgacaact aaatattcat
     7741 aagaaaagaa atagcagtag tataataatc tatattatat tactgctatt tcttttctta
     7801 tgaagtttca acttttttaa tagtgacttt tacaatcaca ctctaaccta atttctttac
     7861 tatttctgat aactttaatg tatgttcatc taataaagtt agttcctctt cagaaagatt
     7921 agataatttt tttactagag attctttgag aatagctttt actgcatcaa ataatttaaa
     7981 tgctttatct gttaattcaa ccctaagaat ccttctatct tttgggtcag gaaatttatt
     8041 gactaaacca tgttccacta atctgtcaat aatcggagtc atatttgatt ttaaaattcc
     8101 taaattagaa gctatttgag aaattgatga tgaatttgat gtcataagat aaagaattac
     8161 cttagcatgt gatggagcca ttggacattc ttcaaaataa gctttcatta tatcagagtt
     8221 attttgaaac ttttttaaca aatcgctttc tttaaatata ttattttcaa gcacaaataa
     8281 aaaatctaaa aaagagtccg ctattttaag tatattgttg ttatccatat ttgtaacatc
     8341 ccttcaatag ataatataat aaaacattgt tgtttaatat agtataaatt ataaactatt
     8401 aataaattta aaacaagaaa aagttattga ctcataataa ttataaattt ataatcaaat
     8461 tagagaatta taaattgcca ataaagggaa gttttttaat tagtctaaaa ctaaacttaa
     8521 attataagac actttaaatt ctacaacaag ctagtgtgca atatataata ggaggagata
     8581 tgaaaagata tttaatagtt ttcttaatgt gtagttcact gtttttagtt ggatgtggaa
     8641 aaacagaaga atctgaacct gagaaaccaa tagcagtttc tgttcaaaaa gcaataggtg
     8701 gagaaattga aaacacaaat tctttctcag gaactacaaa ggttaaagat gaaacagctg
     8761 ttactgcaca gactgttggc acagttcaag aagtgtatgt aaaacttggg caaaatgtaa
     8821 gaaaaggaga tgaattattg agtataagca gtccagagct agaaaatagt gtaaagcaaa
     8881 gtaaagcctc actagattta gcaaaagcaa gttattcaag tgccactggt ggttcattag
     8941 aggcacaagt aaatcaggca aaaacagctc ttgacaatgc aaagattcaa tatgaggagt
     9001 ctcaaagaaa ttatgacaat aataagattc tttatgaaca ggaagtcatt agtttagacc
     9061 aatttaaaaa aatagaattt tctttagagc aaacaaaaca acagttagat tctgctcaaa
     9121 gagcatacga tacagcaact tcaaaaagta tacctcaagc taaagcactt gctaaaaaac
     9181 agcttgacca agctcaagta tcatataatt tagcaatgag taatttagac aaattaacat
     9241 taacatctcc agtagatggt acaataacag ctaaaaactt tgattcaaag gaaatgataa
     9301 cacaatcaca accagctttt attatttcta atcctaatat actagaagtt gatttaaatg
     9361 tagcagaatc agatataggt aaatttaaga aagatggaaa tgtagatgtt ataattgaag
     9421 accaaaggat tttaggaaaa atagattatg taccttcagt agttgaccct cagacatctt
     9481 tatatcctgt taaagtactt gtaaataata caaacaacaa atttaaggca ggtatgtctg
     9541 ctcaagtaaa cttaagtgtt gaaaaagaaa atggtgctgt tacagtacct aaaaaagcaa
     9601 tatttgaaga aaatggtaaa aaatatgtat acatagcaac aaaagacaat atagcaaaga
     9661 aacacttggt tcaaactgga attgtaacag aggataaaat agaaattaaa agtggtgtaa
     9721 gtgataaaga tacagtgatt atcggaggga taagtcttat ttctgacgga actaagatat
     9781 ttcctgtaga aaaggagaag tagactatga atttaacaca gacttccgtt aaacgtcctc
     9841 tcacaatcat aatggtcttt ttagtattaa tagtttttgg tggtattgga tataaaaaaa
     9901 tgtcaataaa tctaatgcct gatatagaaa taccagttgt aatggtcatg actacttgga
     9961 caggtgctgg tcctcaagac gttgatgaac aagttagtca aaaagttgat gaaagtttat
    10021 ctgccgtttc aaatgtaaaa tctactatat caagttcaca agaaagtgtt tctatggtag
    10081 ttgctcagtt tgaatttgga actaatttgg atgaaataat gaatgatgtt aggtctaaag
    10141 ttgatgcatt acagaccagc ctcccagatg atgcagctaa accaacagtt ttaaagctgg
    10201 atatgaatgc acaggctata ggtcaacttg tcatatctgg aggaaatgaa aatagttcac
    10261 aagccttaag aaaatacgct gaagatgtaa ttcagcctaa aatagaatcc atagatggtg
    10321 ttacttcagc agaccttaaa ggtggagaaa aagcacaggt taatgtaata gctgacccag
    10381 ctgttctttc aaattatgga gttagtttat ccactataaa aggtgtctta tcctctagta
    10441 ataaaacatt cccttatggt tcaattactc aaggtgagga taaaatagtt ttaagagcga
    10501 ttgataaatt agaatcccta gatgatataa aacagattca aattcctgta aaaggaggaa
    10561 atacagttag attagataat ctttgtagtg tagattatgg atatgcagac aaagatagta
    10621 tttatagata caatggaaaa gacagtttgg taatagatat ttctaaacaa caagatgcca
    10681 acactgtaaa agttatgcag agtgcataca aatacgtaga tgaattgaat aaggaaaatc
    10741 ctcaatttaa aattaaaatt gctaatgata caagttcata cataagtgaa tcaataaaca
    10801 gtgtaatgag caacttgctt ataagtgctg ttatcgcatt tattgtaata tttgctttcc
    10861 taaaaagtgt aagagcttca ctagttgttg cagttgcaat accaatttct ataataggtg
    10921 ctatagcaat tctctacttt actggtgaaa gtttaaatct tattactgca agttcattgg
    10981 taatttcagt tggtatggtt gttgataatg ctacagttgt aattgaaaat atatttaaat
    11041 ataggaaaag tggcagattg agtcttgatg attgtgctat tgagggaaca agaactgtaa
    11101 caaatgcaat acttgcatca acattgacca caatagcaat attcttacct atcatgttta
    11161 cagaaggtat agctaaaata acttttgggg cattaggtaa aacactaata gcttcactag
    11221 cattctcctt tataggtgca attacactcg ttcctagtgt atttgcaaaa ttaagcagag
    11281 gaaaaaatag tcaaaagatg caagaaaaag atagtcctat atttgataag gtaagtgaag
    11341 catataaaaa attattaagt gtatgtttga gacatcaacg cttagttgta atatcaagtt
    11401 tacttatttt tgtagcttcc ttatttggaa tgggatttat aggaatggac tttatgcctg
    11461 cagcagacaa gggtgaatta tctatttcta tagaacttcc aaaaggtctt agcctagaat
    11521 ccaatgatta ctatgtatct atgactgaga aaaaagtctc agatattcca gaaattaaaa
    11581 ctttaataac aactttgaca tcagattcaa ataatagtaa agcaagtata gcaattgaat
    11641 tagaatctca aaaaaataga aaaagaacta ctgatgaaat agaaaaagag ataattgata
    11701 gagtggctac tgtaccagat tgtaaaataa atgtaagtca aaacagtagt gttatgggtg
    11761 gagctggagg agcagacttc acattagaaa tgaaaggtcc tgatttagat gtattaaaaa
    11821 tactgggaaa agaagctgaa aaagaattta gctctataaa aggatttaga aatgttgaaa
    11881 cttctcttac agatacaaca caagaagctc aatttactat agataaacat aaggctcaag
    11941 aatatggtgt aaatactgct gaaattgcag gcatgttacg tacagcaata aatggtgact
    12001 ctgtaaccac tgctactatt gatgattaca aagtggatgt aaacctaaaa tttaaagcag
    12061 atactattga tagcttagaa gatataaagc aactaaaagt aaactctgca actggaaaag
    12121 aagttcctct tggtgctttt tcagatataa aaatggcaga tggtctacaa tctatatcta
    12181 ggactgatgg agatttttct gtaaatataa ctgctacact tgacaattta gatgctggta
    12241 ctgctacaaa actagcacta gaaaaaacga ataaaatggt aattcctaaa gattactcta
    12301 taggtgttgg tggtgaaaca gaaatgatga atgaatctat ggcaagtctt ggattttcaa
    12361 tggtcatagc tatagcatta gtttatatgg taatggtagc tcagtttgaa tcatttagta
    12421 aaccatttat aatcatgttc tgtgttccat ttgcattcgt tggagttgtg ctttcgcttc
    12481 tagttagtgg tcaaagttta agtactgtcg gtatgctagg tataatctta cttatcggta
    12541 ttgttgttaa taatggtata gttcttattg actacataga gcaacttaga aaaacaaatc
    12601 gtaacaatga tttaattggt ttggtttcaa ttggttgtgc agcaagatta agaccagtct
    12661 taatgactac agcaacaaca attttaggta tgttgccaac agcactatct cttggtgaag
    12721 gtggagaaac tatgcaacca ctagccatag ttataatggg tggtctaact gtatctacac
    12781 ttataacttt ggtgcttata cctactatat acttaatatt tgataaatgg gaaaataagt
    12841 tttcagacaa aatgcctaaa atatttggta agataacaga taaaatagga agtataaaac
    12901 gtaaaataat aaagaaacca aaattgaaag ctaaagttta aatagaatgg agggtgattg
    12961 tattgaataa aaaaatgagc aaaatagttg caattggctg tggtgttggt ataataactg
    13021 ccaatttaat cccagtttac gcagataata atacttcttc tataaacaaa gttgataatt
    13081 ctattttaag tgactcaaat aaaagaacat ctgaaaagga aattttgact gctagagaag
    13141 ctgttagtgc tgcacttaaa aatagtgaaa aattaaaaat gaaatcagaa gaaataaaaa
    13201 tgttaaaaga aaagttagaa gtacaagatg agtttgatag ttttactgga agtgacaact
    13261 cgtttccata cgaccaaatt ggacttctta aaaatcaaag tgaacaggct aaaggcttta
    13321 tggaggacca aatagcaaat gatattacta ataaatttaa cgatttagtt tcaagagaaa
    13381 atgagctaga taagataaaa aacaatcttg aaataaaaac taaagaaatt aaagatatga
    13441 aattaaaaaa agatttaggg ttagtaacat ctttagaaac tgaatcagct gaacttgaac
    13501 ttcaaacact acaaaatact caaaaagcta aacttcaaga actaaaaaac aatcaagact
    13561 attttaagtt attgactaat atagatttaa ataattatca attggataaa gaatatagat
    13621 ttgaatcttt tagagtaggt ggctcagttg attcatatat ggaaggtaag gttaatgaat
    13681 atttaaaata cgaccaattg attttagaac gtacagaaga aagctttaat gataaagatg
    13741 agaacaaagc agatttacca gatagaccta accttacaag accagttgct cctacaaaac
    13801 cagagcaagg taacctaact gatgatgaat acaaggttct tatggataag tatgaaaaag
    13861 attatgatag atataaaaaa gaagttgaag catacaatct tgaaagacag acttatgctg
    13921 ctggtcttac tacttatgca aattatcttc aacaaaaatt taatactgaa aatggtctag
    13981 taacattaga agacagtaaa aaagctctta aaaaagggtt aattgatagc tatgctcaat
    14041 tacttgcttt agaagataca attcagatta ctaaaaaaca acttgattta tcagaaaaac
    14101 aattaaaaaa tactaaatta agatatgatt taggattaat tactctaact gattataaaa
    14161 aacaagtggt aagtaatgaa gatgctaaaa atagctatga ctctcttatt gtgaattata
    14221 actcactaaa aaatggtata gaaaaacctt ggatacttaa tactggaaaa taattctggt
    14281 aaatagaaag attactttaa catacgtttg attaaaaaat agttatgcac actcgtggct
    14341 ttagtcatgg aatattcaga aggcaaataa tagaaataga ttagtaaaaa tatatttact
    14401 tataaaactg tatactttta tagaggctat ctcaaaatag agataagcct cttttttatt
    14461 gtttaaatta taaaaatata tttgattcca tacaaaaaga gtgccttatg aactaaaaag
    14521 ttcattttga gacaccctca aaagcttaac tctaaattta attatttttt atcaaatgtc
    14581 tcatctattt tacatctcac catgttaaca aattcagaaa tattatatcc tctaagtttg
    14641 catccacatt taggacaata atccagtttc ctagatacca aagccctaca actaggttct
    14701 ggacatctta tttttagact ctcatctgct actttaaatc cacatcgtgg gcatatacta
    14761 cctggacgtg atgatacttc ctttccacat ttaggacact ttgtcaactt tatcccctcc
    14821 agtaaactca atttaattga tagttgaaat ttctctctac aataatatat gcaatataat
    14881 taaatacgtt tcacttacaa ctatataagt taaattttta taataaaaat cccctatatt
    14941 caatttacaa atacttaatt tgatacattg aacaataggg gattttattt ttatttagtt
    15001 acatattttg cagtctatta ttatctagga ttttttatag atgcttgagc tgctgcaagt
    15061 ctagcaattg gcactctaaa tggtgaacaa gatacatagt taagtcctac actataacag
    15121 aactctactg aagatggttc tcctccatgc tctccacata ttcctagttt taattctggt
    15181 ttaacttctc tacctaattt agctcccatc ttaactaact taccaacacc attttggtct
    15241 agtacttgga atgggtcttt ttctaatatt tcttcatcta catattgacc taagaattta
    15301 ccagcatcat ctcttgaata tccaaatgcc atttgagtta agtcattagt accaaaactg
    15361 aagaagtctg cttcttgtgc tatttcatca gcagttaaac aagctctagg tatttctatc
    15421 atagtaccta cagtataagg aacttctata ccttcttctt ttattatagc gtcaacagtt
    15481 tctactatca tttttcttat tatttttaac tcatttactt ctccaactaa tggaaccatt
    15541 atctctggag aaactttaac acctgctttg attgcttcta tagcaccttg tattatagct
    15601 ttagattgca ttacacatat ttcaggataa gttattgcaa gtctacaacc tctgtgtcca
    15661 agcattgggt taaactcatc taaatcaact attctcttct taatatcact tacttttatt
    15721 cccatagatt ttgaaagttc ttctatagtc tcatcatcat gaggcaaaaa ttcatgtagt
    15781 ggtgggtcta gtaatcttat attaactggt tttccatcca taactttaaa taactctaca
    15841 aaatcctctc tttgcattgg taatattttt tcaagagctt tttctctttg ttctactgta
    15901 ttagataata tcatttctct aactgctggc aatctagctt catcaaagaa catatgctca
    15961 gttctacata gacctatacc ttctgcacca aactctatag ctgcacgagc atctctagga
    16021 ttatctgcat tagttctaac catcatacat ttgtgtttgt ctacccagtt cattaatttt
    16081 tcaaaatttc cagttaaaga tacttctgtt ttcttaacat ctcctaggta cacatttcct
    16141 gtagaaccat ctatagaaat gtattctcct tcttttataa ctacatcatc aagtgctctt
    16201 atttctttat taaactcatc aacttttatt tctccacatc cagcaacaca acatttaccc
    16261 atacctctag caacaactgc tgcatgtgat gtcattccac ctctagctgt aaggattcct
    16321 tctgctttaa ccattccttc tatatcttct ggagatgtct ctagtctaac taaaactact
    16381 ttttctcctt tttcatttgc ttttactaca tcatcagcat tgaaataaac tttaccactt
    16441 gctgcacctg gtgatgctgg taaacctttt gctataacct tagcttcttt taatgcctta
    16501 tcttcaaatt tgggatgtaa taattggtct aattgattag gctcaattct catgatagct
    16561 tctttttcat caattattcc agcttcaact aaatcaaccg ctacatttat tgctgctgct
    16621 gctgttctct taccatttct agtttgtagt atatataatc tttcattttc tatagtaaac
    16681 tctatatctt gcatatcttt ataatgacct tcaagtatat gagtaatttt tacaaattca
    16741 tcgaatacag ctggcattac atctgcaaga gttgatatat tttgaggagt tcttatacct
    16801 gcaacaacgt cttcaccttg tgcattcatt aaaaattcac caaataattt attttctcct
    16861 gtagctggat ttctagtaaa tgcaacacct gtaccactag tttctcccat attaccaaat
    16921 accattgatt gaatatttac tgctgttcct aagttatgag ctatatcatt caatttacgg
    16981 tatacgattg cacgaggatt attccatgat ctaaatacag cctctattgc aagcattaat
    17041 tgctcttttg ggtcttgtgg gaaatcattt tttatttctt ttttataaat tgctttaaat
    17101 tcttttacta tttcttttaa atcatcagtt gtaagttctg tatcaactgt gtatcccttt
    17161 gcttctttta ctctgtctaa tacgttttca aatttatatt ttggaacttc catagcaaca
    17221 tcagaaaaca tttgtatgaa tcttctgtaa ctatcatatg caaatctttc attttgtgta
    17281 gcctctgcta agccaacaac actattgtca ttaagaccta ggttaagaat tgtatccatc
    17341 attcctggca tagagaatac tgcaccagaa cgaactgata ctaataatgg attcttattg
    17401 catcctaatg ttttatttaa atctttttct aaagtagcta aatgctcttc tatttctttt
    17461 attatctctg ctcttatact ttcattgtta acataataat cattacacgc ttctgttgtt
    17521 atagtgaatc caggagggac aggtaagcct atcttagtca tttctgctaa attggcacct
    17581 ttacctccta gtaaagattt catgtctttg cttccttcac caaaactata aacatactta
    17641 gtttccattg ttaaatcccc cattaatctt tttattttaa tttatatcat ttttattaat
    17701 agacattatt aaatttctat ttctttgtat atctttagac cattttcttt cattatgtct
    17761 aaaattatac ctgctgtttc ttctattgcc ttatttgaaa cgtttattac tgggcatcca
    17821 attcttttca ttatctcttc tgaataatct aactcctgaa gtattctttc taaattagcg
    17881 tagtttgctt tactggacaa tcctaaagct tttaatcttt gggttcttat ctcattcagc
    17941 ttttcaggtg aattagtaag acctattatc tttttagtat ctatctcaaa cacttcttta
    18001 ggaattggta tttctggaac taatggaaca ttagctactt ttatattttt attagctaaa
    18061 tacatactca aaggagtttt agatgttctt gatattccca ctaaaattat gtctgcttga
    18121 agaacacctc tagggtcttt cccatcatca tatttcactg caaattctat agcttcaact
    18181 ctcttaaagt aagattcatc taattttcta attataccag cttctctttt aggttttctt
    18241 cctgttctct tgcttatttc tcttagtata tctgtcatta aatctataca actaagacct
    18301 tctctttcgc aatatctttc aacaatactg cataattctt catcaactaa tgtatataca
    18361 attaaagcgt tttcagcttt tgcattctcc aaagtttcaa gtagtactcc tttattaatc
    18421 atgtatggaa atctttttat ttcataagtt tcattcacat aaaactgaga catacatgcc
    18481 tttgcaactt gttgtgcagt ctcccctact gaatctgata ctgcatatat aattaggttt
    18541 ttcaccagca tacctcctta attgtcaact atttctaaga atagcttagt tatgttggtt
    18601 tttgatattc tcccaacaac tctcatatga tttttgtctt ctcccttata ttcaacaatc
    18661 ggaatcgaat ctacttcatg ttctattatt tttcttgaag ctaataaaac acttgctcct
    18721 ttagttaaag tgactacatt tggagttctt gtcattatca tacctattgg cattttattt
    18781 atatcagaac ctcctatagt tgcttttagc aagtcttttc tggaaacaac tccacataac
    18841 tcttcattct catctataat aactatactc cctacatcag ataaaaacat agtgactatt
    18901 acatcatata tactttcatc cttcttagct agtacaggca tgctcattat atcctctact
    18961 gttttttctt ttacactttt accaattaaa tttatttcac taactcctga ataaaaatat
    19021 ccaacttttg gccttgcgtc taatattcct gtcattgtta atatagctaa atcagatcta
    19081 agtgtagcac gagtcacatt caagctggag gcaatacttt cactcgttat tggttcattt
    19141 tccttaacta tatctataat ttttagttgt ctttcattaa gctgaataat aatcaccttc
    19201 tttcattgtg ctatactttt tatcttttcg catcttatat agtatattat ataactatat
    19261 ataccattct gtaaacagat tttttattga atacgatata ttttttacta agttctctcg
    19321 cttaaagata tttattatat attaatgggg gatatttctt taattaatag aactatatta
    19381 gtattacagt taatattata atacataatt ggtcatttta attcatttta tattaaaatt
    19441 tttaataata ttgtttcaat gtgaatataa aattgcagaa ctaattcaaa ataattttta
    19501 cgactacaaa taacctataa tatactttta aagaaagtat cctaacaaga atatataaaa
    19561 atttaaaagg gttgatttaa aaataaccat caaccctttt tactaatatc tatttatatt
    19621 accatcaaat cttacccaaa tattttttct tgcaattgtc ttaaatgata taaagtagta
    19681 tctttttcta tctctaccat atcgtaagtt ataacttcac cttttttaat atcttttaca
    19741 actttagtct ttttacttat caaaccaata ggtacagcat tcatagcctt tgctacatcg
    19801 tatttttcta tagtaccata gcatgtatat gctccatagc catccataaa ctcacctttt
    19861 ttcaaatctt tcttagctat agtcataact tctgctacta gtccagcttt aggtactatt
    19921 gtagccttat ggtctaaaac tgccatagct gctgataaag gagtctctaa actacataaa
    19981 tgatatggtc tatataatat gtaattaggt ccatcaccca tacttaaata ttttagttca
    20041 tcattaactg cttttaattt atgggcaact actacgaaaa ctccaggtgc tataccattt
    20101 acaaaatcaa ctacaccata attatctaat actccacctt cgctttttaa tgcatatttc
    20161 ttaggtactt cattaactgt agcttcaata ccatgaccac ctcttacatc aggcacaaat
    20221 ccagttgcat tacacattaa agccatttct accattgttt tagttccttc tttaaaagaa
    20281 gctatcatat gaggtgaagc tccttttctt tctgcttctt ctctaactgt atcaggatta
    20341 caatctaaat ctaatttatt atttttacct ttacctatca ctctaacttc aaaccccatt
    20401 gcatctgcaa aatcaaataa ttccattact gcacctggct catctcctgc agaacctgta
    20461 aatattactc cagcatcatc tgctaatttt ttaagtattg gtccaacaac acaatcagtt
    20521 tcagcattta acataactat atgtttttta tttaaaatag agtttaatgc tatctctgca
    20581 ccaattgcaa tacccccagt tgcatctata actacatcta ttgacttagt tttacaagcc
    20641 acaagaaagt cattacatgt caatactttt ccttcttgta attttatttc tgcatccttt
    20701 tcatttgtta cattatctat aatttcttca tctattcctg catcagtaaa agctttatga
    20761 gccaactcca aatttatatc tacaacaata gaagcttcaa tacctttcat atttgccatt
    20821 tggcttacca ttccatttcc catatgccca gctcctataa gagctacttt tattttttta
    20881 ccttcctctt ccaattttgc aagttttctg tttaaatcta acataccaat tcctcctgtt
    20941 ataataattt tattttcaaa ttaagaaata gttattaaat ctccaatagt tatatctgga
    21001 tttcctattt ccacatgtat ttctcctggt aaatttactt cacattttcc atcaaatttg
    21061 attgtacaat gcccaatttc tctaagagtc ttctgagcaa tatcaccaac tgaaactata
    21121 caataatctc tattccctat agtaagtgta tctcctattt caacatcact ttttaatgtt
    21181 gctattgaat gaattacaga tatatccttt aagtcgtcat cattaatggt ttcatcatat
    21241 ataataagac aattgctttc atccattaac tctttaacta aactgcctat cccacttatc
    21301 ttaacttcat atttcatgac attcctcctg ataatttata tttatattga gttaattaaa
    21361 agaaacattt attttttctt ttataaattt tatagcttgt acaatactct cttcatcttt
    21421 aaatttttgc tctgcactat atatatctaa tccttctatt tcttcaatct ctttaaattt
    21481 agccattact gtacgccctt ttaaaatttc tccaaacttt ataaacccat ctgaatctga
    21541 agatataatg gctatacttc ctttagaaaa atagcttttc tttttgcctg tagacactat
    21601 atcacccttt tttttagctc tatttaaagt tttaaaatac aatttattct gcttcattat
    21661 aaatatagta tttaaaatat aagcaacaaa taaaattact aataatttca tatttataca
    21721 ccttccaaaa atcacattat ttttaaatct gtataacaac tataaatgct gtacaatagt
    21781 tatataaggt ttttaagtaa caccttttta aattctaaaa aagttctaca tttacttatc
    21841 ttattcgtta attttacatc ttggcctatc tttaaaactt cttcataaat ttttactaat
    21901 aagtctgagt ctatcttatt ctcacatgga aacattgtca taagaattat ttttatactt
    21961 ctatttgcat attctattgg ttcttctaaa attccaactg ccattaaaaa cttatctgat
    22021 ttttcattta tagaatgagg aaataataaa cctttatcaa atactgtggg agatttttct
    22081 tctctattga ctatattttt tctaaacttc tcatcaatac atcccaaatc cataagatgg
    22141 tccatcattt tttctaatga ggcaagtata gtcttttcat ttaatatcat aaatttatct
    22201 tcatctaaca aattatttat tagtaaattt gtagaattag tagtgtcaat attcccttct
    22261 cttaggcaca atactgtttt taattgttct cttagtttgt tttcatcaaa tattgtattt
    22321 atttttaata ctattgtatt tatatttgat gtgtctaaat caatagtcgt aaaaactata
    22381 tcgtattcat ctaagttaat atttctcaaa ttaaaacttg aaagagtatc aattttagga
    22441 ttatttccta tcagtttttc tactcttatt ttcaatagtt ttgctgttcc tagacctgta
    22501 ctacatataa ttgctatttt ttttattgaa tagaatctac tgctatttct ttctaaatat
    22561 ccactgaaat ggattgctat atatccaatc tcatcttctg aaacttctaa gttatacttt
    22621 ttctctatta cttttcctgc tatttgtgct aatttaaatg gaagtataca attttgctta
    22681 atctcttcta acaaaacatt ttttaacttt atattaaata atagcctgtt taaagtaaaa
    22741 ctaagatgat atcctagacc tactcttaat tcatcctcat ttataaaaat acccatatcg
    22801 acatatattt gattaaatat attttccatc aactcatcaa tgtttttact aattctacta
    22861 ctatttaaag cacattctga tgctggtgca tttccactaa ctaacggtat agttaaataa
    22921 ataatttctt catcatttaa agtacattca aacattcctg atattatatg ttttatttcc
    22981 ctagcaataa agtattcatc atatgattta agtaaatcaa actttacatc ataatctttt
    23041 actttctttt cttcttttac tctatagact aaaactacta tgtagttaat aacttctctt
    23101 aacatttcat ctgtaacata aaaattattt tttttaaata aagtcaatag tttttcttct
    23161 aaatttatga tttcttcttt tttgattcct ttaaaatact ttgaattact taaatctttt
    23221 cttgagtttt tatacaactg atttaatata aacagtctaa tatcaagttc atttccattt
    23281 aatttcatac ctgtattctg ttttttaatc aagtttaaat tatatgaagc caaaactttt
    23341 tctacatact ggaaatcatt tactaaagta gttcttccta cacacatctc atcagctaaa
    23401 ctatcaagtg taataaatcc atctagttct atcaagtaat ttagtataaa ctctactcta
    23461 tcttcttttg aatttaatga aaatacattt tttctattca tatcaataat cttattgagt
    23521 atctgctcat cttttatttc tagtttatag ccttgaccct ttatatattt gattactgct
    23581 atatcattac ctaaatcttt attcaattgt tttatatacg tccttacact tctagttgtg
    23641 acattcaatt catttgctat tgagttaata ctcacaaact cttttttact acacataatc
    23701 aatatcttaa atatcttgcg gtcaatagaa ggaattttct cagttacact cattttgtat
    23761 ctcctccttg atttcattct agtacaaatt tgaaaccaaa ttaatacata aaatttcact
    23821 ttaataaagg aaaatttagt attaatctaa ctcgataatt acagctaatt aatagtataa
    23881 aagctagtct ttcattaaca aaaaatcttg actagcttaa atttatattt acaattttat
    23941 taattaattc caagccttat attgacatta aatattatct caatgcaaat actgcaactc
    24001 catatgcaat aataacagct attggaccag ttattaaacg agagtaaaat aaagctggaa
    24061 caccatactc tacagtttct ggttctgctt ctcccaaact taatcctact ggtacaaaat
    24121 cacatccagc ttgcccattt attgcaaata aagctggaag tgctaaatat gctggtattg
    24181 caccaagacc aatttgtgta cctacaagag tccctactac ttgagctata actgcaccag
    24241 gtcctagtat tggtgataag aatggaagtg tgcaaattac tgatataatc aataatccac
    24301 caatattacc tgcaagtgga gatataactc ttgcaatcca gtctcccagt ccagatgcta
    24361 aaataattcc cataagcata cttacaaatg ccataaatgg tattacgtta ttcattacca
    24421 tttggatagt atctcgacct gcatcataaa attttgatac tacttgccct gccccttgac
    24481 caatagaaag tattatgttc tttttagcat attcaccttg tgcttttgac ttaacctcat
    24541 cataattatc aggctttcta atagaactct tattttcgct tttattttct tgagattttt
    24601 gtggcatatc ttccccatct acaacactta tacagttagg attaacatct gatacataat
    24661 attcttctgt tataaatttt gctaaaggac ctgtttttcc aactggattt acatttattg
    24721 taggtatttt tttctttgga taaactccac atctagcagt tccaccacaa tcaataataa
    24781 ctactgctac ttcttcatca gaaactccag ttttaaatcc atctacaatt tcacaaccca
    24841 gtagttcttt tatttttaat gttacttcat ggataccgcc agcagtcatt gatagtatct
    24901 tatttctatt cccttctttt tttatataca aaggacctcc ccagcctgaa gttccctttt
    24961 ctatttttaa tattttattc tcctccattt tatctacctc ctaagcctta tttgttgctc
    25021 tattttttct tgttagaaaa gcatacattt tttctgttac tatacctctt ataaaaatta
    25081 caattagacc aactataaaa taccacaatg ccagtgtagt agtttcttta cctaaagtag
    25141 tcaaacctgc tgatattccc aaccatacaa aaagttctcc tgcatttgca tgtggaaaaa
    25201 gacctgtaat tggatgtaca aatgaaactg ctgcatcata aaatcctgct ttgtgctctt
    25261 cttttaaaaa tctaccaaat gtatagcaca taggatttcc caagaaaaat actgatacta
    25321 atggaagtag aatatatctt gtaaaagagt tctttcctag cttagaagcc caattattaa
    25381 ctctttcctc accaattatc ttaatcaaag agttaatagc taccattaat acaattagcg
    25441 ttggaagagt acctgaaaca agacctataa attgttctcc ccctttctga aacaaaccga
    25501 taaaccactc tgcaccttta cttagacctg taataacgtt ttccataaaa ttataacctc
    25561 cctataatat ctttaaattt ttaattttac tgcttaccat aaattttaca aattacatct
    25621 tttttctgta ctatatgcta atattgtaaa tgttttttta ttaatatcat tttaatataa
    25681 tatttttgat aaataaatac atcttttttc aattttataa aggaaaaaat tgtactaatt
    25741 agaattttca gaaatataca attcttattt cgactatatt ctaaattctt cttagaaatt
    25801 taagaactta tttttatttc ttttattatt aaaattatct aaatctgata aaaataaaaa
    25861 atagatgctc ttttacgaac atctatttct taatcaaatt atcttttagt tttcttatag
    25921 attattttat aggtatataa atatcaattt gtgagttcac attactagga cctaaaaatc
    25981 gttcatcata tacttcaaaa tcatctctta tatcaagttc ttcttttgaa cttaaaagcc
    26041 aagtacccca tatatattca taagttttgt ctaaattatc taagctacca gtatgagtaa
    26101 atatagcata ctttccttcc ttaatagttt ttgaaacaaa tgaatttgga atcacatcat
    26161 aactattaac ttcaagtcct attatctcat taaactccat actttcacta actaggtgta
    26221 tttcagagat tgcttcacag attccaaaaa ctctctttga tggcaaagta tttgggacaa
    26281 tatgatgtac ttttctgaat ttctcccaca agtcaggtaa tgaattattt tctaaaatta
    26341 ctttatcctt tatacctatt acctttattt tttctatttc ttttataact ggtttaatcg
    26401 ttatatttcc aacaagatgt ctcataaaat ctaactctaa ttttttcttt ttaccaacaa
    26461 atacatcaat tctatttttt ctatattcta tagggctaac cttgtatata gatttaaatg
    26521 ctctgctaaa tgcttctgaa gattcaaatc cactaccaat agctatatct atcacttttt
    26581 tatcactata taaaagttct tttgtactac ttactaatcg tctttttttt atataacttc
    26641 ctacactctc accaaacata gacttaaata agcgtgttaa atgataataa gaatatccag
    26701 tttcttttgc cacatcattt acagttatat tttcatgtaa attattctca atatacatta
    26761 cagctttttc aaaatacttt aagtaatcca atatggcacc tctcttctac ttaaactctt
    26821 taaatatgta aaatagcact attttttact atactaaaat attataacta attcaatacg
    26881 ataaataaaa acttttagtt gatttatata tcctaattat ttagaataat tgaatacatt
    26941 ttttattcaa tgaaatcaaa aaagtcagat ggtgcttttt caatatttat gtttatcctc
    27001 tgtgttatag atttaatgtc attttttaaa tagtagctct cccatttatt ctctagtcca
    27061 ccccataaaa tattaaactt tcctatattt aaatccataa ctatactttt taaagttcca
    27121 aaaaaatcat tatagtaatt acaagataag ccatttggat attttgaaga caataaattc
    27181 attaactctt tctctccaat ttttttagac ttatttatat attctttaat taatttatat
    27241 ctatgaatag aatttttcat tgattgtgga tctaatttat gaagtttatc aatatgtgta
    27301 tgattagtag agtgtaaaaa atattctctt ttactttcta aactgttgat tatatttact
    27361 tcttttttcc catctaaagt ctccacaagt gcaatgtttc cagacttatc tgcaagcaat
    27421 aaattaatat tgtatgcaat tggcatatct tttaaatatt ctaatgcttc atctacatct
    27481 ttgcaatttt ctaacaaata tctaataaca gcccaaaact gtaaacctac aattgctggt
    27541 tttcttaaac catctgaatt gcctacagga ataccacatg atgactgact tacacctaag
    27601 ccacattcat tcataccttc acctcttcca aattgcataa tggtagtacc tatatgtgca
    27661 tattttccat ttaccttagt tttacataaa acaaaatcct ccatattgtg tgagaaatcg
    27721 aaattacgtg caaatagtac atgcccattt tcagttaatt ctggtgctaa tgcaacttga
    27781 ctacaacctg gtttaagata agtcatagta taatataaaa tttgattaca attcacttga
    27841 attgcatcag caaaaccttg caattcttca ttaagacctg gacaatattt atcaaacaac
    27901 tctatcatct ctttttcttc ttttttgctt accagattag atttattaat ctgaccttct
    27961 attatctctg gcatattagc aaccaattct cctagtctgt atcctatctc ataatttgta
    28021 ccactcaatt caatatttct tacttctaaa gtttccacat gtacccctcc tatatatctt
    28081 ataatcgatt ttatcattcg aattgtaatc attcatgata ttttgtgcta caagttaaaa
    28141 aaggtcatat aaaaacagat aagcctcttt ttcatgttta aaataataaa aatatattta
    28201 atttcataca aaaaagagtg tctcataaac taaaaagttc cttttgagac actcttctta
    28261 ttttaaagag tataattaaa aatagtctaa gttctactct tccttcattt ttttcaataa
    28321 ctctggattt tcaaataaat taaatcctgt taaagctaat atttttatac catcaattac
    28381 tctatctttt gcatatgaat ttatagaagc ctccaaaaat tcttttgtat gtagttcttc
    28441 tccattttca gaaaacttca tcaaaggatg tatacatggc attatttgac ttaaatttcc
    28501 catatctgtt gaacctaaca ttacttgttc atcttcatat attccaaatt cctccataat
    28561 ctttgtaaat atgtctacca aaactttatt ttcatttaat ccttggcaag ttggttcaaa
    28621 gtgataaaat tcaagttcac atccagtggc tattgcagca cctctagcac aatttttcac
    28681 tttttctact acttcatcaa agtaattttg ttcttttgcc cttatctcta atcttacttt
    28741 tcccatatca ggtattacat ttgcagcagt tcctgcttct agtataatac catgtattct
    28801 cgttccatct actaattgtt gtcttagtgc atttatatta ttatatagta gtactactgc
    28861 atctaaagca tttattccgt tatatggctt agctcctgca tgagatgctt ttccagtaaa
    28921 tatgaaatct agacctccta ttgctataat ttcaggtgtt acacaagttt ttgaattagg
    28981 atgtatcatc attgctgcat catagccatc aaatacacca tgttctatca agtaaggctt
    29041 tccatctcca gtttcttcag caggtgttcc aattatactt acttctccct tgtaagtatc
    29101 cagtatactt gaaagagcta ttccagctcc aactcccata gatgcaatta aatgatgtcc
    29161 acatgcatgt ccattgcctg gaagagcatc atattctgct ataaatgcta ttttaggacc
    29221 atctccattt ttcttggttg ctttaaaagc tgtagccata cctgccaagt tttcctcaac
    29281 atcaaaaccc tcttctctta aaaattctga tattttttta gcagatttat attcttgcaa
    29341 agcaatttct ggttcatcat ataaagattg acatagccct agaatttttt ctttctttga
    29401 atcagccact tgtattattc tttctttcat accaatctta cctcccacta aatttattta
    29461 gtaattttta tattttatta taactttaat ttaactcatg cttatcctct tttaagtatc
    29521 tattttccca aaactcagca tttcttatat ctaactctat agggttaaaa gttctatcac
    29581 tcctttttat tcccatcttc ttctgtctta tataatcata atatgccttt atagctggtt
    29641 tttttagtgt aaagatggca attaaattta tatatgttaa tacacctata catatatcac
    29701 ctaatgccca gcttgtaagt ggttctataa aacaacacat tgctgcacat gctataagca
    29761 taaatctaca gacattaatt atgtactttt catgtttttc tgctttaatt ctagttacta
    29821 agtaagatac attagtctcc atcatatatg agaaggctaa taaagttgta aatgtaaata
    29881 ataataaaac tattgctata aaaatatcac ctaattgtgt atgtaatgta tttattgcac
    29941 tctgtacata ttgtggtccc ggttctacac ctggtagtgc tgtgcaaaca cctgtaacat
    30001 tatacattcc tgttattaca atcataatac ctgtagccat acatattaat aatgtgtcta
    30061 cataaacaga aaatgcttga actaatcctt gtttggctgg atgacttact tctgctgctg
    30121 ccgcaccata agtcccagaa ccttctcctg cttcatttga gtatatacct ctttttactc
    30181 cccaagatat tgctgaacct agcattcctc caaaaactga accaaatcca aatgcagatt
    30241 taaacattgt tacaatagcc tctggaacta aactaatatt tgttataatt attactaatg
    30301 tcataataag gtatgctcca cccattatag gtactacttt ttcagcaaat aaaccaatcc
    30361 ttttaattcc tccaaaaatt attatcgcta atgcaataga agatgctact gctattgtca
    30421 tttttgaaaa tccaaatgct tgattcattg ctagatataa agtgtttgat tgtgtaccag
    30481 gcataaaaaa tgtataactt attattgcaa ctattgaaaa taaaactgaa cactttttcc
    30541 acccaagacc tttttcaaaa taatatggag gtcctcctct atactgccca tcatgctcat
    30601 ctttatatat ttgagctaga gtagattcta caaatgcagt tgctgaacct aatgtagcca
    30661 ttatgcacat ccatactaat gctcctggac ctcccattgc tattgctaca gctacaccag
    30721 ctatatttcc agtccctatt cttccagcca tagatgtagc aaaaccttga aatgatgata
    30781 taccaacatg agaactatct ccttcaagca agagagtaaa catttctttt acatctctta
    30841 tttgaaaaaa ttttaatttc aatgaaaaat ataatcctat acacaaacac attgcaacta
    30901 atacgggtga ccaaacaatt ccattaatgg tgttaactaa atcggtcact taactcacca
    30961 ccattcattt tatatttata gacaataatt taaacagcta tatttcaata ttttacataa
    31021 tctttatatt aatatatcta aaaaatctac cttctattta tttatattat ctttaatcta
    31081 caatctacaa atatttattt ctaaaatcaa gagtattaat catatctaaa cataaattta
    31141 taaaattttt aacgacgtgt gtttgaataa taatcaaaca atataaattg gaatacatat
//
LOCUS       DAEQCW010000040        29675 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.040, whole genome shotgun sequence.
ACCESSION   DAEQCW010000040 DAEQCW010000000
VERSION     DAEQCW010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 29675)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29675)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29675
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.040"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(64..1740)
                     /gene="bclA2"
                     /locus_tag="KRO40_001819"
     CDS             complement(64..1740)
                     /gene="bclA2"
                     /locus_tag="KRO40_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA2"
                     /protein_id="HBH2092640.1"
                     /translation="MSDISGPSLYQDVGPTGPTGATGPTGPTGPRGATGATGANGITG
                     PTGNTGATGANGITGPTGNMGATGPNGTTGSTGPTGNTGATGANGITGPTGNTGATGA
                     NGITGPTGNKGATGANGITGSTGPTGNTGATGANGITGPTGNTGATGATGPTGLTGAT
                     GATGANGITGPTGNTGATGANGVTGATGPTGNTGATGPTGSIGATGATGTTGATGPIG
                     ATGPTGADGEVGPTGAVGATGPDGLVGPTGPTGPTGATGANGLVGPTGAVGATGANGL
                     VGPTGATGATGVAGAIGPTGAVGATGPTGADGAVGPTGATGATGANGATGPTGAVGAT
                     GANGVAGPIGPTGPTGANGVAGATGATGATGANGATGPTGAVGATGANGVAGAIGPTG
                     PTGANGATGATGATGATGANGATGPTGATGATGVLATNNAQFTVSSSSLVNNTLVTFN
                     SSFINGTNITFPTSSTINLAVGGIYNVSFGIRATLSLAGFMSITTNFNGVAQNNFIAK
                     AVNTLTSSDVSVSLSFLVDARAAAVTLSFTFGSGTTGTSAAGYVSVYRIQ"
     gene            complement(2118..2657)
                     /gene="hpt"
                     /locus_tag="KRO40_001820"
     CDS             complement(2118..2657)
                     /gene="hpt"
                     /locus_tag="KRO40_001820"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBH2092641.1"
                     /translation="MDIETKKWEVLYSEEKIKDKLRELGAIIEKDYKDKNLMVVSLLK
                     GSFIFCADLVRNINLPLRVNFMTTSSYGNNEESTGRVKVVSDVTTDIAGYDVLVVDDI
                     TDSALTMDFVLKHLKAKNPASLKCCVLLDKPSRRKVDLVPDYCGFEIEDKFVVGYGFD
                     FGDYYRNVPYIFNVTDEDR"
     gene            complement(2985..4292)
                     /locus_tag="KRO40_001821"
     CDS             complement(2985..4292)
                     /locus_tag="KRO40_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine dehydratase subunit alpha family protein"
                     /protein_id="HBH2092642.1"
                     /translation="MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIV
                     ENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIVGGHSENGLSVLETLTKEEVKIA
                     EDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE
                     PKVSASNDAAEKAESLMDTVTIQELIKNVEGIDFKDIEFLLDGVKMNEEMAEYGLKQK
                     TGIGVGYGIKKSIEEGLLGNDVINYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTA
                     ILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCGCGVAASTGATAGIS
                     WLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVP
                     PLNGIVGSSVEQSIQNLGRVSDKGMSITDEIILNVMNDMNKVD"
     gene            complement(4717..6492)
                     /locus_tag="KRO40_001822"
     CDS             complement(4717..6492)
                     /locus_tag="KRO40_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092643.1"
                     /translation="MMIMIGLEYIKSDIQNIAEAIVSVLNIDVTIVNKELFRIAGTGV
                     YIDKIGEKVDKYTAFKKSLTEQITILIDDPKSSDICRECYKSGACVEFAEVCCPIICD
                     GDSHGVIGLIAFTKEQAQIIENNKSGLINFLGKMADLISNKLKAQIKTYELELEKKKL
                     ETLLNNMDKAVVSIDVDGKIDKYNSKFKELFNIKDSITGKNIFVELDFIKKPSINNFK
                     KDKSCSFFYKRYGYDSKGIYNINKIVLKNELKGYVIDFIDKRDAIKNYNKMNKDYRIK
                     LENIIGESVAIRNSKKEALIASKSTSTVLITGESGTGKELFARAIHNHSNRVDNPFIA
                     VNCAAIPDNLLESELFGYEEGAFTGAKKGGKLGMFEVAHKGSIFLDEIGDMSLHLQSK
                     LLRVLQEKELNKIGSKSNVSIDVRIIAATNKDLEKMVQNGTFREDLYYRLNVIPIKLP
                     SLRERKEDIPLIIKHMVKEYSKKLDKNVIDIDSRVVDAMMEYKWPGNIRELQNIIEYS
                     VNMSSSSIITMNVIPQKIKNTSVEELEVKSDRIIPLDELEKIEIIKALNKYKDYKKDK
                     ELTAKALGISRATLYRKIEKYNIIS"
     gene            complement(6489..6626)
                     /locus_tag="KRO40_001823"
     CDS             complement(6489..6626)
                     /locus_tag="KRO40_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092644.1"
                     /translation="MEINYELIIIVMLFVILMSIQFTLNKIYLILKEIRQILMLKKNK
                     E"
     gene            complement(6704..7273)
                     /locus_tag="KRO40_001824"
     CDS             complement(6704..7273)
                     /locus_tag="KRO40_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH2092645.1"
                     /translation="MKSILCQINKQPVKAKYTSDELECFLDTIEYNVGDKILLVGHIG
                     NLGKRLRGLGTSVTILENSNYEDVCYSLVYNENCNVVKGKLEFLPFDDNQFNKIIIVD
                     QFNVITDCEKASSEIQRVLKGNGEVILEDLNLKNLKVKLNYLKHKFCGSVAKIHYPHE
                     VFNIFSRLNFDGMIKESNKLKYIYVGKRR"
     gene            complement(7457..8092)
                     /locus_tag="KRO40_001825"
     CDS             complement(7457..8092)
                     /locus_tag="KRO40_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH2092646.1"
                     /translation="MIAVKDENNVVNLRGELDNKLEFSHEIFGEKFYNMKIKINRLSD
                     SFDILPMTVSERLLQDIDLDKQNLVNVVGQLRSYNKTLNNKNRLVLTVFVREIKSIDE
                     ENKDPNSIFLDGYVCKEPVYRKTPLGREITDLLVAINRPYNKSDYIPSIVWGRNAKFA
                     KNLKVGDRIQLWGRVQSREYEKKIDENNVVKKMAYEVSISKIKKLDENNNE"
     gene            complement(8760..9641)
                     /locus_tag="KRO40_001826"
     CDS             complement(8760..9641)
                     /locus_tag="KRO40_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBH2092647.1"
                     /translation="MVAILKALYVVFAAIFAVVFGKDVAKANKEGKLEEQSTPKVAVT
                     GFITDFFDTLGIGSFAPTIAMSKALKLNIPDKKMPGTLNVAHTIPVVTEAFIFTSIIP
                     VDGVTLVSMVVAAAVGSYIGAGIIAKMDERKIQLVMGVTLALTAILMLLGHPWINVLP
                     GGGNELGLTGAKLVIGVIGNFILGALMTAGIGLYAPGMAMVYFLGMSAKVAFPIVMGS
                     CALLMPVASMKFIKEDAYTKKASVIIAICGLIGVFVAAYIVKTLPMDILKALVIVVIA
                     YTSATMIMAANKNKKTA"
     gene            complement(9761..10768)
                     /locus_tag="KRO40_001827"
     CDS             complement(9761..10768)
                     /locus_tag="KRO40_001827"
                     /EC_number="5.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline racemase"
                     /protein_id="HBH2092648.1"
                     /translation="MKFSRSIQAIDSHTAGEATRIVVGGIPNIKGNSMPEKKEYLEEN
                     LDYLRTAIMLEPRGHNDMFGSVMTQPCCPDADFGIIFMDGGGYLNMCGHGTIGAMTAA
                     IETGVVPAVEPVTHVVMEAPAGIIRGDVTVVDGKAKEVSFLNVPAFLYKEGVEVDLPG
                     VGTVKFDISFGGSFFAIIHASQLGLKIEPQNAGKLTELAMKLRDIINEKIEIQHPTLA
                     HIKTVDLVEIYDEPTHPEATYKNVVIFGQGQVDRSPCGTGTSAKLATLHAKGELKVGE
                     KFVYESILGTLFKGEIVEETKVADFNAVVPKITGSAYITGFNHFVIDEEDPLKHGFIL
                     K"
     gene            complement(10788..11270)
                     /locus_tag="KRO40_001828"
     CDS             complement(10788..11270)
                     /locus_tag="KRO40_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
                     /protein_id="HBH2092649.1"
                     /translation="MSFVGISTSMKNTSLHIFRDPLLDLIDNDSDIDLLGVVVVGTSE
                     HNEWKTFLATRLGRWIESLRPDGVIITLDMAGNQHIDFTNAIAEFVKSDIPTVGLTIM
                     GADGLVITNPYLDKATIIDYKKTTGYIETEVVGDNHMDEVDVKKALAFLKLKMRKDAK
                     "
     gene            complement(11288..11755)
                     /locus_tag="KRO40_001829"
     CDS             complement(11288..11755)
                     /locus_tag="KRO40_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
                     /protein_id="HBH2092650.1"
                     /translation="MGIGPSTKETSLHHFRDPLLDIVESDKDVDLLGVIVVGTPDGNE
                     NKTFVGQRTAAWLEAMRVDGAIVSSDGWGNSHVDYANTFEEIGKRDIPVVGVTFNGTQ
                     AKFVVSNQYMDTIVDMNKSKEGIETEVVGENNTNEIDAKKALAFLKLKMRKHG"
     gene            complement(11770..12528)
                     /gene="prdD"
                     /locus_tag="KRO40_001830"
     CDS             complement(11770..12528)
                     /gene="prdD"
                     /locus_tag="KRO40_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase cluster protein PrdD"
                     /protein_id="HBH2092651.1"
                     /translation="MEEKIMRRLVIKPFHMNEVNFGSKTSIKKDVLTIDLSSIDEIKE
                     REELITDIKVDIIKPGDYDREINTIMDIIPISTKVLGRLGEGITHTLTGVYVMLTGAD
                     EDGNQMHEFGSSEGILKDQMVFGRYGTPSVEDYIIHVDVTLKGGLPFERTLPLAAFRA
                     CDDFIQEIRASLKMEDGRNATQVREYFDKIRPNAKKVVIVKQIAGQGAMYDNQLFSKE
                     PSGFEGGTSIIDMGNVPMIISPNEYRDGALRAMT"
     gene            complement(12608..13333)
                     /gene="prdB"
                     /locus_tag="KRO40_001831"
     CDS             complement(12608..13333)
                     /gene="prdB"
                     /locus_tag="KRO40_001831"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:complement(12881..12883),aa:Sec)
                     /transl_table=11
                     /product="D-proline reductase (dithiol) protein PrdB"
                     /protein_id="HBH2092652.1"
                     /translation="MSLTTVQGLQSEIFVPITPPPVWTPVTKELKDMTIALATAAGVH
                     LKSDKRFNLAGDTTFRAIPNTATVDEMMVSHGGYDNGDVNKDINCMFPIDRLHELAAE
                     GFIKGVAPMHYAFMGGGGNQHVFTEETGPAIAAKLKEEGVDGVVMTAGUGTCHRTAVI
                     VQRAIEEAGIPTIIIAALPPVVRQNGTPRAVAPLVPMGANAGEPHNIEMQTHILRDTL
                     EQLVAIPSAGKIVPLPYEYKAHV"
     gene            complement(13371..13655)
                     /locus_tag="KRO40_001832"
     CDS             complement(13371..13655)
                     /locus_tag="KRO40_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092653.1"
                     /translation="MDRLKYISSETFYEGIIVDIKGGGVTIDLKGRLGQFKIPNRMLI
                     TDYELKIGQEVGFMLSYPEVLSPEPNQEYVENIRREKEKQAEMQSKQEEK"
     gene            complement(13736..15616)
                     /gene="prdA"
                     /locus_tag="KRO40_001833"
     CDS             complement(13736..15616)
                     /gene="prdA"
                     /locus_tag="KRO40_001833"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-proline reductase (dithiol) proprotein PrdA"
                     /protein_id="HBH2092654.1"
                     /translation="MSITLETAQAHANDPAVCCCRFEAGTIIAPENLEDPAIFADLED
                     SGLLTIPENGLTIGQVLGAKLKETLDALSPMTTDNVEGYKAGEAKEEVVEETVEEAAP
                     VSEAAVVPVSTGVAGETVKIHIGEGKNISLEIPLSVAGQAGVAAPVANVAAPVASAAA
                     EVAPKVEEKKLLRSLTKKHFKIDKVEFADETKIEGTTLYIRNAEEICKEANETQELVV
                     DMKLEIITPDKYETYSEAVLDIQPIATKEEGELGSGITRVIDGAVMVLTGTDEDGVQI
                     GEFGSSEGELNTTIMWGRPGAADKGEIFIKGQVTIKAGTNMERPGPLAAHRAFDYVTQ
                     EIREALKKVDNSLVVDEEVIEQYRREGKKKVVVIKEIMGQGAMHDNLILPVEPVGTLG
                     AQPNVDLGNMPVVLSPLEVLDGGIHALTCIGPASKEMSRHYWREPLVIRAMEDEEIDL
                     VGVVFVGSPQVNAEKFYVSKRLGMLVEAMEVDGAVVTTEGFGNNHIDFASHIEQIGMR
                     GIPVVGVSFSAVQGALVVGNKYMTHMVDNNKSKQGIENEILSNNTLAPEDAVRIMAML
                     KNAIEGVEVKAPERKWNPNVKLNNIEAIEKVTGEKIVLEENEQSLPMSKKRREIYEKD
                     EN"
     gene            complement(16045..17805)
                     /gene="prdR"
                     /locus_tag="KRO40_001834"
     CDS             complement(16045..17805)
                     /gene="prdR"
                     /locus_tag="KRO40_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54 dependent transcriptional regulator
                     PrdR"
                     /protein_id="HBH2092655.1"
                     /translation="MFSIPEVKKVEEVMDTKFTTIDEDTRIEDAIKEMIKSNTKTLMV
                     IDSSDQLKGIISMTDIHNLYEMHKKYEGQPVKLIMKKDVIYVNEGLTLDECRDIMILK
                     NIGILPVLRDNKIIGVLKQEHIRDYLYMHLEDYGLTLKYIIGQIKEGICAINNEGVVI
                     LWNKFMEERYDIKSEDIVGRPMNEFLENTISEKVLNSKVGMSDLYFTDKKENMYALVH
                     ANPIFYKEEFIGVVCTEVDVTEAKILALELEKVNDTLKYLKNEVKNLSKGSFDKILGK
                     SYKLEKSKAIAKQVARTNSSIFIWGESGTGKEVFARAIHDYSERKGQFIPVNCSAIPN
                     ELFESEFFGYESGAFTGASKKGRIGIFELAKDGTVFLDEIADLPLSMQAKLLRVLQEK
                     EIRRVGGDTTIKINPRIISATNKDLSKMVKAEKFREDLYYRLNVVEIKIPPLRERKED
                     IGLLVHSFLEEICKQNNKPVLTISKDVIDIFQNYRWKGNIRELKNTIENIVVLSQNSK
                     IDVDDVPSYMMDSTNNSTEEEEYPLDLTKATQKIEIKNITKALKMSNGNKAKAAKILN
                     IPRTTLYYKIDQYKIDVSKI"
     gene            complement(18212..20320)
                     /locus_tag="KRO40_001835"
     CDS             complement(18212..20320)
                     /locus_tag="KRO40_001835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-Gln thioester bond-forming surface protein"
                     /protein_id="HBH2092656.1"
                     /translation="MKTKIKKSSIISLVIAFSMVFTAFTPIVSYADEVTSNDTILNGE
                     EQSNGQTPDVEKPSDGQVPDGEKPLDGQIPDGEKPSDGQIPDGEKPSDGQIPDGEKPS
                     DGQIPDGEKPSDGQMPDGEKPSDSQTPDVEKPSDGQMPDGEKPLDEQIPEEEKPLEEE
                     IVIEEMSLKQDIDKILDMTLSQINKIVYNFWEDEEDVKADEQSEINQVFTSEDSFISL
                     WYDKKAKVKNSCLLKEIDGSDRPYHDLRFDDITKTLTFDYVIKGLVGASSKDDKYVIE
                     GEDGEQTAFCYNNHLRPPSSNGKSPYLPAEDFNGQENQNEEAVKSILYAGSEFDGFGY
                     KQQFNLGEEENDIMTYSATQSAIWIILGQIDEQERLKQYQGSIDLCDKLIEIAKTEEE
                     RAEYQKRKEVAINTKAYLEALLKAGREELKPNDTGKPSLSNGLTKINFEKNEDGTYET
                     EAVALVGYSGVVKLKLPDGVTAYDVDGNIIGTGEVEISTQQKFKLKSVGKPDAKANIS
                     AVSYDYIFPKAIQYYKAVLDLGQKDHSSSLPSSKQNLLSYTIEKKNGQEVNFNIGLPT
                     DDVVNPPVPPTDDTNGHKPKPSPPIDDTVINPPVPPMDDTIINPPVPPTEDAVLNPPV
                     PPTEDAVLNPPVPPTEDTVLNPPVPSVSDTVEKTPELSRDDTIIKSPKTGDETQLMSY
                     VFISVIAICGLAYQCKIKRN"
     regulatory      complement(20902..20987)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            complement(21390..22703)
                     /gene="prdC"
                     /locus_tag="KRO40_001836"
     CDS             complement(21390..22703)
                     /gene="prdC"
                     /locus_tag="KRO40_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase-associated electron transfer
                     protein PrdC"
                     /protein_id="HBH2092657.1"
                     /translation="MNKLYSILLKQHVGGPDKPVVSVGDVVKKGTLIAEPTGLGANIY
                     ASVSGKISEINDQAIVIEADEVQEDTFEPLKGEGILDLIKEAGVVGMGGAGFPTHVKL
                     NIDLNGGTILANAAECEPLLAHNIKEIEERPEIVYQGIKYAMEVTNAGKGMLAIKSKH
                     PKAIEAFKKVIKPGDNIEVAELVDMYPMGEERAIVRDVLGKLLEPTQLPSEANAVVIN
                     VETLTRIVEAVEQKRPVISKNITVVGQLNSGKESIVFEDVPIGTTVGELIERAGGIKG
                     EYGEIILGGPFTGKATTLDAPITKTSGGIIVTMPFVNEKRKMGLLVCACGPNEERMRD
                     IATKMGVTDIVSVQKCKQAQEIKGALKCENPGHCPGQAQKCIEFKKAGAEVILIGNCT
                     DCSNTVMGSAPKLKLGVYHITDHVMRTVNHPLIRRIKGDVRLKIK"
     gene            complement(23092..23856)
                     /locus_tag="KRO40_001837"
     CDS             complement(23092..23856)
                     /locus_tag="KRO40_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2092658.1"
                     /translation="MKREVKRTKALIYSVLFFSLLLVLIFVFVYGIKYICSKSDNSKM
                     PIYKVDTNEKKIALSFDVAWGTDNMDDILKILDKHNVKATFFLVGSWVDDNEEIVKAI
                     DEKGHEIGNHSNTHANLKEISKEDITKEIETTSEKIYNITGKKTNLFRPPFGDVNNKA
                     MDICSDLGYKVIKWDVDSIDWKELGPNHVIEKVIKESQPGSIVLFHANINDVDNYLDT
                     IISRLKKDGYSLVKISDLLYKDNYVVDSNGVQKTKN"
     gene            24147..24350
                     /locus_tag="KRO40_001838"
     CDS             24147..24350
                     /locus_tag="KRO40_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBH2092659.1"
                     /translation="MSNSNRTVVPEAKAALNQMKLEIANEIGLSNYENIDKGNLTARE
                     NGYVGGYMTKKLVEMAERQMAGK"
     gene            24541..25077
                     /locus_tag="KRO40_001839"
     CDS             24541..25077
                     /locus_tag="KRO40_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4364 family protein"
                     /protein_id="HBH2092660.1"
                     /translation="MFENSSEELAYHKLLILYILEKIKMDLTNSQITQVVLETEMMNY
                     FSLQQLLSQLMESKFLTTYKDSDREYYALTQRGVESLEYFFNRIPTSVTEKIDKYIDS
                     NKENLLADTQVKSSFVKQSDNEFIVNLRVIENQSNLIDLNLNVSSEKQAKLICNNWKN
                     NASYMYAEVIDLLIRDIH"
     gene            complement(25081..25947)
                     /locus_tag="KRO40_001840"
     CDS             complement(25081..25947)
                     /locus_tag="KRO40_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YncE family protein"
                     /protein_id="HBH2092661.1"
                     /translation="MKIYISNYLSKSISIVDYSTLELEKEIVLEDNIYPHHFCIEKEK
                     NLIYIPSSSNGILYVLDLSNDKIIDTVSIGGSLSQVVLSDNELFVANEDSNSIYVLDK
                     NTLNPIGIIGVDNMPHGFDFDRESKKLYVPCINSIVCIDTINKNIQKKINMDFRAWHI
                     ELDKQKKEMYISTLDGKLIIIDEVSMDIKKVLYEFLLPVEIRFNYSGKKVYVADLGYN
                     NVRILDYTTSRYIGNIEINGIPQGLEISKDEKLLFVSDTQENSVKVYETANNKLIKEI
                     KVGKEPTTIICL"
     gene            26095..26340
                     /locus_tag="KRO40_001841"
     CDS             26095..26340
                     /locus_tag="KRO40_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBH2092662.1"
                     /translation="MKVTFNPSGVCCREMIFEVDENNVIVDAEFIGGCNGNLSGLRSL
                     IIGQNALEVADKLNGIDCGGKGTSCPDQLSKAIRQSI"
     gene            complement(26454..27752)
                     /locus_tag="KRO40_001842"
     CDS             complement(26454..27752)
                     /locus_tag="KRO40_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HBH2092663.1"
                     /translation="MKYEEALEYISQTNKFGIRLGLENIGKLLELLGNPQETLNIIHV
                     AGTNGKGSVCSFVSNILRECGYKVGLYTSPYLETFTERIRVNGQNIPQDDVARIIELI
                     KEKIEIMVKEGYAYPTEFEVVTAMAFYYYSEQKVDFVALEVGLGGRYDATNIITKSLV
                     SVIVSISLDHTGILGDTIEKIAYEKAGIIKENGVVLVYDQTDEAKDVIKSVCKEKKAK
                     YIEVDFDDINIKKSDINSQIYDCTVMKETYRDLEIKLIGEHQINNSILAISVIKYLKD
                     INKLANINEESIRKGLINTKWPGRIEKIKENPIFIIDGAHNEDGAKSLAKALDKNFKG
                     RKLTLLIGMLEDKDIDSVLEILLPHFNKVITTTPNNPRAINSDILREKVLKYVDDVTS
                     KHEIEDAVNYTLETSSEDDIIISAGSLYMIGTVRTLVKKL"
     gene            complement(27885..28916)
                     /locus_tag="KRO40_001843"
     CDS             complement(27885..28916)
                     /locus_tag="KRO40_001843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBH2092664.1"
                     /translation="MENICDMNNKVKVAVLDTGIDKEHDYLKDNLVGGIAFECMHDYI
                     FISDKFDDEDGHGTACASIIKKEYEDVELFVIKILRKDGITNIKVLEEALRYLLDTNI
                     RLINLSLSVIGVESVKGLFEVCYELFRKGKIIVCSLANDFDLSYPAMFNNVIGVRGFT
                     LDGDDSFWYNKKYDVQCVMDSNSYISCDINNSYRLPPKCNSYLSAKLTGKIAKILSEK
                     PGITISDLNDKLESLATRNHWDSCDFDECSRIVNFKLDLYDKENALFMKVADVVRDCL
                     DIEENNEKLFKGSLFNKEIGLVYDNCFNLLKKLEHRFDIKFNYMDISKYDLVSIYTLT
                     ELVERYKNL"
BASE COUNT         8868 a         5545 c         3399 g        11863 t
ORIGIN      
        1 attctattta ttggtatatg aaatcatatt gtttattatt ttataatctt ttcatcatat
       61 aaactattgt attctataaa ctgatacata tccagctgca gaagtacctg tcgtgcctga
      121 accaaatgta aaacttaaag taacagctgc tgctctagca tcaactaaaa agcttaaact
      181 tacacttaca tctgatgaag taagtgtatt tactgctttt gcaataaagt tattttgagc
      241 tactccatta aagttagtag taattgacat aaatcctgca agtgaaagtg tggcacgtat
      301 accgaaagat acattgtata tccctccaac tgcaagattt atagtactac ttgttggaaa
      361 agttatatta gttccattta taaatgatga attaaatgtc actaatgtat tattcactaa
      421 acttgaagag gacactgtaa attgtgcatt gtttgttgct aacactcctg ttgctcctgt
      481 cgctccggtt ggacctgttg ctccatttgc tcctgttgct ccggtcgccc ctgttgctcc
      541 tgtcgctcca tttgctccag ttgggcctgt tggtcctatc gctcctgcta ctccatttgc
      601 tcccgttgct cctactgctc ctgttgggcc tgttgctcca tttgcccctg ttgctcctgt
      661 cgctcctgtt gctcctgcta ctccatttgc tccggttgga ccggttggac ctattggacc
      721 tgctactcca ttcgctccgg ttgctcctac tgctcccgtt gggcctgttg ctccatttgc
      781 ccctgttgct cctgtcgctc ctgttggacc tactgctcca tctgctcccg ttgggcctgt
      841 tgctcctact gctcctgttg gacctattgc cccagctact cctgttgctc ctgtcgctcc
      901 tgttggacct accaaaccat ttgctccggt tgctcctact gctcctgttg gacctaccaa
      961 accatttgct ccggttgctc cagttgggcc tgttgggcct gttggaccta ccaaaccatc
     1021 tggacctgtt gctcctactg ctcctgttgg acctacctct ccatctgctc cggttggacc
     1081 tgttgctcct attgggcctg ttgccccagt tgttccggtt gctccagtcg ctcctatact
     1141 tccggttgga cctgttgctc ctgtatttcc tgttggtcct gtcgctcctg ttactccatt
     1201 tgctccggtt gctcctgtat ttcctgttgg acctgttatt ccatttgctc cggttgctcc
     1261 ggttgctcca gttagtccgg ttggacctgt tgctccagtt gctcctgtat tccctgttgg
     1321 tcctgttatt ccatttgctc cagtcgctcc tgtatttcct gttggtcctg tagagcctgt
     1381 tattccattt gctccagttg ctcctttgtt tcctgttggt cctgttattc catttgctcc
     1441 ggttgctcct gtattccctg tcggacctgt tattccattc gctccagtcg ctcctgtatt
     1501 tcctgttggt cctgtagaac ctgttgttcc atttggtcca gtcgctccca tatttcctgt
     1561 tggacccgtt attccattcg ctccggttgc tcccgtattt cctgttggac ctgttattcc
     1621 atttgctccg gtcgctccag ttgcacctct aggccccgtc ggtcctgttg gaccagtagc
     1681 acctgttggc cctgttggac ctacatcttg atataaactt ggacctgaaa tatcactcat
     1741 ataattaatc ctcctttttt aaagttagag tattactcta taaatattga gtattactct
     1801 atataattat atgaatcgac aatttcttat gtgataatgt atctatttgc ttatatcaac
     1861 atatatgctt tgattcttga atttcattac ttttttgtaa aatcttttac aattattagt
     1921 actcttttac aattattaat acaattaaaa aactcatttc ccatcaatta tttaaaattt
     1981 ttttattatg ttataaaaaa tagataatta aattgcataa aattaattta atactacttt
     2041 aattactttt taaataaaaa aacctcaaca cgattaataa aaatcatatt aaggcatcca
     2101 caaaattata taattgctta tctatcttca tcagtaacat tgaatatata aggaacattt
     2161 ctataataat caccaaaatc aaacccatat ccaaccacaa acttatcttc tatttcaaat
     2221 ccacaataat ctggcactaa atcgactttt cttctgcttg gtttatccaa aagaacacag
     2281 cattttaaac tagcaggatt tttagctttt agatgtttta acacaaaatc catagtaagt
     2341 gcagaatcag taatatcgtc tacaaccaaa acatcatatc ctgctatatc agtagtcaca
     2401 tctgaaacta ctttaaccct tccagtactt tcttcattgt ttccataact agatgtagtc
     2461 ataaaattaa ctctaagtgg taaatttata tttctaacta agtctgcaca aaatataaag
     2521 ctacctttta atagagaaac taccataaga tttttatctt tataatcttt ttctataatt
     2581 gctcctaatt cccttaattt atctttaatt ttttcttctg aatacaatac ttcccatttt
     2641 tttgtttcta tatccataaa aagacctcca attgtaataa tccttcttaa ttttataaga
     2701 gattgctcac tttttcaata ctcttattca atattagtca atattattga gtttttatgt
     2761 tcattcaaca attattaaca atgtatctta tattttaagt agttcatata tccacactaa
     2821 attacatact atatatttta gacaaaaaaa gaaaaaactt gcactaacaa gttttttcta
     2881 ttatacataa atttatacat aatcatattt tattagaggg tactaattaa atttatttat
     2941 gctatttttg ttatacctca taatacaaaa catattataa agtactagtc aactttattc
     3001 atatcattca ttacatttaa gattatctca tctgttatag acataccttt gtcacttact
     3061 ctacctaagt tttgtatact ttgctcaaca cttgaaccaa ctataccatt tagtggtggt
     3121 acaaaacaat cttgcttagc tattatagca ctttgtatag ctgcagatgc tgcagaagat
     3181 aattttaatg cacaaccagc tttcgcaccg tcacatatca ttccacttaa gtcagctatc
     3241 atattttcta tagctccttc tatttgcttt tcagtaccat tcataagcca agagatacca
     3301 gcagttgctc cagtagaagc agcaacacca catccacata cagcagataa tcttcctgta
     3361 tagttcttaa tataaccagt tactagatga gatatagcta aagcttttgc tagtctttca
     3421 tcagattgtg ggaatttttt attataagca acgattggaa gaattgctgt taatccatga
     3481 tttccacttc catttgaact cataacaggc atttttaccc ctgccattct tgcatctgaa
     3541 gctccagcag ttaacatcat tgcataattt ataacatcat tacctaaaag accttcttct
     3601 atagactttt taattccata tcctacacca ataccagttt tttgttttaa tccatattca
     3661 gccatctctt cattcatttt tactccatct agtaaaaatt ctatatcttt aaaatcaatt
     3721 ccttctacat tttttattaa ttcttgtata gttactgtat ccattaaact ttcagctttt
     3781 tctgccgcat catttgaagc tgatactttt ggttcattgt ctaataatac ttctccatct
     3841 ttttctaaga acgtaaaatt atcatgttta gttcttattc tcactttagc aatatgattt
     3901 tttcctttta acacaacttc tataaatact ttctctcttg tatcagcagg tgttattgat
     3961 agtggagtat tatccatata atcctcagct attttaactt cctcttttgt tagagtttct
     4021 aacacactta atccattttc agaatgtcca cctactatac ctagagctgc tgcaattttt
     4081 aatcctaatc tttcagtacc tggtatacct acgcacatac catttttata aatactagga
     4141 ctaactaaca tacgattttc aactatttct tctcctaata attcctttgc ctttgcacat
     4201 gctagagcta aggctactgg ttcagtacac cctactgctg gtttaacttc tgcctttaac
     4261 atttccacta attcttttct tatatctctc attatatata aacctcccaa ttaagtttag
     4321 atttagtact caaataatta attaaataat ttcttatcta tatttatagc aaaatacatg
     4381 ccatattttt tatatctttt tatattttta gtcttatatt ctataaccat tggtatgact
     4441 gcttctattt atgtattttt tttatttaca tagagtattt atattcttta aaatggagaa
     4501 acatatgaca atttcgcaaa aagacaaaaa aaagtctcaa aatgagattc tatatcattt
     4561 tgagacggct caaatgtatt attttttaac ttataaaaac cattttttaa ttcataaaaa
     4621 aagattctgc aaaacactta tagtataagt ttaaagcttt ctttaaagtt atgaatttag
     4681 aaaaatttaa attttatata gctttttatt atattactat gaaattatat tgtatttttc
     4741 aatttttcta tataatgtag ctcttgatat tccaagtgct ttagctgtta attctttatc
     4801 ttttttataa tctttgtact tatttaaagc ttttattatc tcaatcttct ctagttcatc
     4861 aagtggaatt atcctatcgc ttttaacttc taactcttct acagaggtat tcttaatttt
     4921 ttgaggaatt acattcattg tgattattga agaagaagac atattcacac tatattcaat
     4981 aatattctgc aactctctta tattccctgg ccacttatat tccatcatag catcaacaac
     5041 cctgctatct atgtcaataa catttttatc taattttttt gaatactctt taaccatatg
     5101 cttgattata agtgggatat cttcttttct ctctcttaaa cttggtaatt ttataggtat
     5161 aacatttaat ctatagtata aatcttctct aaaagtgcca ttttgaacca ttttttctaa
     5221 atctttattt gtagcagcaa taattcttac atctattgaa acatttgatt tacttccaat
     5281 tttattaagt tccttttctt gtaatactct caataacttt gactgtaaat gcaaactcat
     5341 atctcctatt tcatctaaaa atatacttcc cttatgagct acttcaaaca ttccaagctt
     5401 tccacctttt ttagctccag taaaagctcc ctcttcatat ccaaataatt cactctctaa
     5461 taaattgtct ggtatagcag cacagtttac agctataaaa ggattatcta ctctattgct
     5521 atggttgtgt atggctcttg caaatagctc cttacccgtt ccactttccc cagtaataag
     5581 tactgttgat gttgatttag aagctattag ggcttccttt ttagaatttc ttatagctac
     5641 actttctcca attatgtttt ccaattttat tctataatct ttattcatct tattgtagtt
     5701 ttttatagca tctctcttat ctataaaatc aataacatat ccctttaact cattttttaa
     5761 tactatttta ttgatgttgt atattccctt cgaatcatat ccgtatcttt tataaaaaaa
     5821 actacaggat ttgtccttct taaagttatt tatagaaggt ttctttataa aatctaattc
     5881 gacaaatatg tttttgccag ttatactatc ttttatattg aaaagctctt taaattttga
     5941 attatattta tcaatttttc cgtccacatc aatagacaca acagctttgt ccatattgtt
     6001 taatagtgtc tctaattttt tcttttctaa ttcaagctca taagttttaa tttgtgcttt
     6061 taatttatta gatattaggt ctgccatttt gcctaaaaag tttataagac cacttttatt
     6121 attttctata atttgtgctt gttcttttgt aaaggctata aggcctataa caccatgaga
     6181 atcgccatca catataatag gacaacacac ctctgcaaac tctacacaag ccccactttt
     6241 atagcattcc ctacatatat cactactctt tgggtcatca attagtattg taatctgttc
     6301 tgtaagtgat tttttaaaag ccgtatattt atctactttc tcacctattt tgtctatata
     6361 tactcctgta cctgcaatcc taaataactc cttatttact atagttacat ctatattgag
     6421 tactgatact atagcttcag ctatattttg aatatcagat tttatatatt ctaaacctat
     6481 cataatcatc attccttatt tttctttagc ataagtattt gtcttatttc tttaagaatc
     6541 aagtatatct tatttaaagt aaattggatt gacatcagga ttacaaagag cataacaatt
     6601 attattaact cataatttat ttccatctaa acatctcctt ataacaaaag actaggctta
     6661 acctagtctt ttatattata tccatattta tattttaact catttatctt ctttttccca
     6721 cataaatata ttttaattta tttgactctt taatcatacc atcaaagttt aatcttgaaa
     6781 atatattaaa tacttcatgt ggatagtgaa tctttgcaac agaaccacaa aatttatgtt
     6841 taagatagtt taacttaact tttaaattct ttaaatttaa atcctctaat ataacctctc
     6901 cattgccctt taacactctt tgtatttcag atgaagcttt ttcacaatct gtaataacat
     6961 taaattggtc aactattatt atcttgttga actgattatc atcaaatggt agaaactcta
     7021 acttaccttt aactacattg caattttcat tatacactag agaataacag acatcttcat
     7081 aattactatt ctccagtata gttacagaag ttccaagacc tctcaatctc ttgcctaggt
     7141 ttcctatatg accaacaagc aatattttat cacctacatt atactcaatt gtatccaaaa
     7201 aacattctaa ttcatcagat gtatatttag ctttaactgg ctgtttattt atctgacata
     7261 atatgctttt cacaatgctt cacctcttca tttcctcaat tataaattat gtacagatta
     7321 cattataata aatggcgagc aactattcaa gagatatttc attagtattt ttttaaacaa
     7381 tctttataca ttttaatatg atattatacc aaatttatta ggattttatt cataaaaatc
     7441 agtctatttt ttatgtttat tcattgttat tttcatccaa tttttttatt ttcgatatgg
     7501 atacttcata tgccattttt ttgaccacat tattttcatc tatttttttc tcatattctc
     7561 tactttgaac cctaccccaa agctgtattc tatcaccaac ctttagattc tttgcaaatt
     7621 tagcatttct accccaaact attgatggta tataatcaga tttattataa ggtctgttta
     7681 tagcaactaa taaatcggtt atttcccttc ctaaaggtgt cttcctatac acaggttcct
     7741 tacatacata tccatctaaa aatatactat tagggtcttt attttcctcg tctatacttt
     7801 ttatttctct gacaaacact gtaagcacta atctattttt attatttaat gttttgttat
     7861 atgatcttaa ttggcctacg acattgacta aattttgttt atcaaggtca atatcttgga
     7921 gaagtctttc tgatacagtc attggaagta tatcaaaaga atcgcttagt ctgtttattt
     7981 ttattttcat attataaaat ttttctccaa atatctcatg gctaaattct agcttattgt
     8041 ctaactcccc tcttaagttt actacgttat tctcatcttt aacagctatc atattttatc
     8101 cctccacaat tgttaattct tatatttctg gtatcagctt atataataaa tatatttata
     8161 agggatgtat tttattacaa atctttgatt gctgtttaaa agtttttatt tagttataaa
     8221 tttcatttaa tatttcactt ttataattat aaaattatta tctttttgta ccacatatac
     8281 taattaaact acctatttca gttttgtatt aattataaaa atcctattat ataattaata
     8341 agtcatatat aacttaaatt tattcactct atataagcaa cttcaacgaa ttaaatttat
     8401 tgaaataatt cagatgaata ttgagtcatt ataaacttat ttttcttaat tataagttat
     8461 attagactta ttacaggtta tatttttatt aatctgtatt aatatatgaa catttattga
     8521 acttattgat tataaaattt aaatatttag ctttaaatta tgctttattc tttaaaaata
     8581 caacgttttt tagattaaat ctactaaatc actatatata ttacataatt ggcatgttaa
     8641 ttgctttata ttaatttagt aaataaaaaa ctgccctaaa atattaattc aatattttaa
     8701 agcagtttat aatctttatt attagctgta atatttaata aacactaagt agtctttaac
     8761 taagcagtct ttttgttttt atttgcagcc attatcattg tagcagaagt ataagctata
     8821 actactatta ctaatgcttt taatatatcc attggtagag tttttactat atatgcagct
     8881 acgaaaactc ctattaaacc acatatagct attataactg atgctttttt agtatatgca
     8941 tcttctttta tgaatttcat acttgcaact ggcattaata atgcacaaga acccataact
     9001 attgggaatg caacttttgc agacattcct aagaaataaa ccattgccat acctggagca
     9061 tatagaccta taccagctgt cattaaagct cctagtataa agttacctat tacacctatt
     9121 actaatttag caccagtaag acctaattca tttcctccac ctggtaatac gttaatccaa
     9181 ggatgaccta ataacattaa tattgctgtt aatgctaaag ttacacccat aacaagttgt
     9241 atttttctct cgtccatctt agctattatt cctgcaccta tatatgaacc aactgctgct
     9301 gccacaacca tagatactaa agtaacacca tctactggga taattgatgt aaatatgaat
     9361 gcttctgtaa caactggaat agtatgtgct acgtttaatg taccaggcat ttttttatct
     9421 ggtatattta actttaaagc ctttgacatt gctattgttg gagcaaatga ccctattcct
     9481 aatgtatcaa agaagtctgt tataaatcct gttacagcaa cttttggagt actttgttct
     9541 tctagtttcc cctctttgtt tgctttagct acgtctttac caaacacaac tgcaaagatt
     9601 gctgcgaata ctacatataa tgcctttaag attgctacca taatccatcc tcctattttt
     9661 ttattttttc atatattctg aatcttatag cctaaaagct atagaatagc aaccgacaag
     9721 tggctactat tctattttaa tttcctaatt tatttattac ttatttaaga ataaatccat
     9781 gtttaagtgg gtcttcttca tctattacaa aatgattaaa tccagttata taagcagaac
     9841 cagttatttt aggtactaca gcattgaaat ctgcaacttt agtttcttca actatttcac
     9901 ctttgaataa agttcctaat atactttcat atacgaattt ttctcctact tttaattcac
     9961 ctttagcatg taaagtagct aatttagcac ttgttccagt tccacatgga gatctgtcaa
    10021 cttgaccttg accaaatata actacatttt tgtaagtagc ttctggatga gttggctcat
    10081 catatatttc aactaagtct acagttttta tatgagctaa agttggatgt tgtatttcta
    10141 ttttctcatt tattatatct ctaagtttca tagctagttc agttaattta ccagcatttt
    10201 gaggttcgat ttttaaacct aattgacttg catgtattat agcaaagaag cttccaccaa
    10261 atgatatgtc aaatttaaca gttccaacac ctggtaagtc aacttcaaca ccttctttat
    10321 ataagaaagc tggtacgttt aagaatgata cttctttagc ttttccatct acaactgtaa
    10381 cgtctcctct tattattcct gctggagctt ccataactac atgagttaca ggctctactg
    10441 ctggaactac acctgtttct atagctgctg tcatagctcc tattgtacca tggccacaca
    10501 tgttaaggta tccgccacca tccatgaaga ttattccaaa gtcagcatct gggcaacaag
    10561 gttgagtcat tacagaacca aacatatcat tatgtcctct tggctctaac attatagcag
    10621 ttcttaaata atctagattt tcctctaaat attctttttt ctcaggcata gaatttcctt
    10681 ttatgttagg tattccacct acaactattc tagtcgcttc acctgctgta tgagagtcta
    10741 tagcttgtat acttctgcta aatttcatat caaattcccc cttaggttta ttttgcgtct
    10801 ttacgcattt ttaattttag gaaagccaat gcttttttaa catcaacttc atccatgtga
    10861 ttgtctccaa ctacttctgt ttctatgtag cctgttgtct ttttataatc aattatggta
    10921 gctttatcca aatatggatt ggtaattact aatccatctg ctcccataat agtaagacct
    10981 actgtaggta tatctgattt tacaaactct gctatagcat ttgtaaaatc aatatgctgg
    11041 tttcctgcca tatctaaagt tataatcact ccatcaggtc gcaatgattc aatccatctt
    11101 ccaagtctag ttgctaaaaa tgttttccat tcattgtgct ctgatgtccc aactacaacc
    11161 actcctaaca agtctatgtc agaatcatta tctatcaaat ctagtaacgg gtctctaaat
    11221 atatgaagtg atgtgttttt cattgatgta gaaattccca caaaactcat tcccttactt
    11281 aaatttttta tccatgtttt ctcattttaa gttttaaaaa tgccaaagct tttttagcat
    11341 ctatttcatt tgtgttgttt tctccaacta cttctgtctc aataccttct tttgatttgt
    11401 tcatatcaac tatggtatcc atatattgat tgcttacaac aaacttagct tgagtcccat
    11461 taaatgtaac tccaactaca ggtatatctc tttttcctat ttcctcaaat gtgttagcgt
    11521 agtcaacatg tgagtttccc caaccatctg atgaaactat agctccatct actctcatgg
    11581 cttccagcca agcggccgtt ctttgtccca caaaggtttt attttcattt ccatctggag
    11641 ttcctactac tattactcca agtaaatcta catccttatc actttcaact atgtctaaaa
    11701 gtgggtctct aaagtgatga agagatgttt cttttgttga aggtcctatt cccataatat
    11761 ccacctctct taagtcatag ctctaagggc accatctctg tattcattag gagatataat
    11821 cataggtaca tttcccatat ctataattga tgttcctcct tcaaatccac taggttcctt
    11881 tgagaataac tgattgtcat acatagcacc ttgacctgct atttgtttta ctatgacaac
    11941 cttttttgca tttggtcgaa ttttgtcaaa atattcacga acttgagtag catttcttcc
    12001 gtcttccatt ttcaaagacg ctcttatttc ttgtataaaa tcatcacatg ctctgaatgc
    12061 tgcaagtgga agtgttcttt caaaaggtaa acctcccttt aaagttacat ctacatggat
    12121 tatataatct tcaactgatg gagttccata tctcccaaat accatttggt ctttcaaaat
    12181 tccttctgaa gaaccaaatt catgcatttg atttccatct tcatctgcac cagttaacat
    12241 tacatataca cccgttaaag tatgtgtaat accctctccc agtctgccta aaacttttgt
    12301 tgatattggt ataatgtcca taatagtatt aatttctctg tcataatctc caggttttat
    12361 aatgtctact tttatgtctg ttattaactc ttctctttct tttatttcat ctatacttga
    12421 taaatctatt gtaagtacat ctttctttat agaagttttt gaaccgaaat taacttcatt
    12481 catatgaaac ggttttataa caagtcttct cattattttt tcttccataa tatccacctt
    12541 tgttcttaaa acccctctcc taaccgtgta ggagaagggt tctatatttt caaatataaa
    12601 ttacatttta aacgtgagct ttatattcgt atggtaatgg aactatctta ccagcagatg
    12661 gtattgcaac taattgctct aatgtatctc ttaatatatg tgtttgcatt tctatattat
    12721 gtggttcacc agcattagca cccattggaa ctaatggagc aactgctcta ggagttccgt
    12781 tttgtctaac tactggagga agagctgcta ttattattgt aggtattcca gcttcctcta
    12841 ttgctctctg cacgatcacg gcagttctat ggcaagtacc tcagccagct gtcataacta
    12901 caccgtctac tccctcttcc ttaagtttag cagcgatagc aggaccagtt tcttcagtga
    12961 agacatgttg gtttcctcca ccacccatga atgcatagtg cataggagct actcctttga
    13021 taaatccttc tgcagctaat tcatgtaatc tatctatagg gaacatacag tttatatctt
    13081 tgtttacatc tccattgtca tatccaccat gtgataccat catttcatca actgtagctg
    13141 tattaggtat agctctaaat gtagtatctc ctgctagatt aaatctcttg tcagatttta
    13201 aatgaacacc agctgctgta gctaaagcta tagtcatatc ttttaattct ttagttacag
    13261 gagtccaaac tggaggaggt gttattggaa cgaatatttc agattgaagt ccttgtactg
    13321 ttgtaaggct catatatttc ctctcccttc tattttcaaa cgattattta ttatttttct
    13381 tcttgttttg attgcatttc tgcttgtttt tctttttctc tcctaatatt ttctacatac
    13441 tcttgattag gctctggact taatacctca ggatagctta gcatgaatcc aacttcttga
    13501 cctatcttaa gttcgtagtc agttataagc attctattag gtattttaaa ttgtccaagt
    13561 ctacctttta ggtctatagt cactccaccg cctttgatgt caactataat accttcataa
    13621 aaagtctctg atgagatata ttttaaccta tccattataa ttctacctct ctatactgtt
    13681 ttaaacttgg atctaaattt atgttattgt ctaaatctta gttagtatct aaattttagt
    13741 tttcgtcttt ttcgtatatt tctcttctct tcttactcat tggtagagat tgctcattct
    13801 cttctaatac tattttttct cctgtaactt tttctatagc ttctatgtta tttaatttaa
    13861 catttggatt ccattttctt tcaggagctt taacttctac accttctata gcatttttaa
    13921 gcatagccat tattctaaca gcatcttctg gagctaaagt gttgttagat aatatttcat
    13981 tctctatacc ttgcttagac ttattgttgt ctaccatgtg agtcatgtat ttattaccaa
    14041 caactagagc accttgaaca gctgagaaac ttacaccaac tactggtata cctctcatac
    14101 ctatttgctc tatgtgagat gcgaaatcta tatggttgtt tccgaaacct tcagtagtta
    14161 ctacagctcc atcaacttcc atagcttcaa ctaacatacc taatctctta gatacataga
    14221 atttctcagc atttacttgt ggagaaccaa caaatacaac acctactaaa tctatttctt
    14281 cgtcttccat agctcttatt actaatggct ctctccagta atgtcttgac atttcttttg
    14341 atgcaggtcc tatacaagtt aatgcatgga taccaccatc taatacttca agtggagata
    14401 atacaactgg catgtttcct aagtcaacgt ttggttgagc tcctaatgta ccaactggct
    14461 caactggtaa tattaggtta tcatgcattg caccttgtcc cattatttct tttataacaa
    14521 caactttctt tttaccttct cttctgtatt gctctattac ttcttcatca actactaaag
    14581 agttgtcaac tttctttaat gcttctctta tttcttgagt tacatagtca aatgcacggt
    14641 gagcagctaa aggtcctggt ctttccatgt tagttcctgc ttttattgtt acttgacctt
    14701 tgatgaatat ttcacctttg tcagcagcac ctggtctacc ccacattata gtagtattta
    14761 actcaccttc tgaagaacca aattcaccta tttgaactcc atcttcatct gtaccagtta
    14821 ataccattac agctccatct ataactctag ttatacctga acctaattcg ccttcttctt
    14881 tagtagcgat tggttgtata tctaatacag cttcactgta agtttcatat ttatcaggag
    14941 ttattatttc taacttcata tctacaacta actcttgagt ttcattagct tctttacata
    15001 tttcttctgc gtttctgatg tataaagtag ttccttctat tttagtttca tcagcaaatt
    15061 caactttatc tattttaaag tgttttttag ttaagcttct taaaagtttc ttttcttcaa
    15121 cttttggagc tacttctgct gctgcacttg ccactggagc agcaacgttt gctactggag
    15181 cagcaactcc tgcttgacca gctactgata aaggtatctc taagcttatg ttcttacctt
    15241 cacctatgtg tattttaact gtttcacctg caactcctgt gcttactgga actactgctg
    15301 cttctgatac tggagctgct tcttctactg tttcttctac tacttcttct ttagcctctc
    15361 ctgctttgta tccttctacg ttatctgtag tcattggaga aagtgcatct aaagtttctt
    15421 ttaacttagc tcctagtact tgacctatag ttaatccatt ttctggtatt gttaataatc
    15481 cagaatcctc taagtctgca aatattgctg gatcttctaa gttttctggc gctataattg
    15541 ttcccgcttc aaatctacaa caacaaactg ctgggtcatt tgcatgggct tgagctgttt
    15601 ctaaagttat tgacatagta taaaatacct ccttacatta ttttcttatt tattatttta
    15661 aatctcaatt cctcaacagg taacccctta actgagaaat taagtaaatt aaaacctaca
    15721 taatttgtta tgattaatat tatttttttc tcacttaaag tcactttata ttataagcaa
    15781 ttcctatgcc aacttattaa caaaaagatt ttttctataa tagattcttc atctatcgct
    15841 atttttagcc aaatattata taaatattta tttaaaatat gttatttttt gtatttgtaa
    15901 acattttctc aaacaaaaaa agtgtcaatt aatcaacact ttttcatttt ttttaacaca
    15961 tctatataca caacacttat ataagcgttg gctttactag gttttaaatt aaagtttatc
    16021 attttgtcaa aatttagtca tgtgtcatat tttagacaca tctattttgt attggtctat
    16081 cttataatac aaagttgttc tgggtatatt taatatctta gctgctttag ctttatttcc
    16141 attagacatt ttaagtgcct tggttatatt ctttatttca attttttgag ttgccttcgt
    16201 taaatctaaa ggatactctt cttcttcagt actattattt gtagaatcca tcatataact
    16261 tggtacatca tccacatcta ttttagaatt ttgtgacaat acaacaatat tttcaatcgt
    16321 attttttaat tctctaatat tacctttcca tctataattc tgaaatatat ctattacatc
    16381 tttgctaatt gtaagaacag gcttattatt ttgtttacat atctcctcta aaaagctatg
    16441 aaccaataat cctatgtctt cttttctctc tctaagtgga ggaatcttta tttcaacaac
    16501 atttaatcta tagtataaat cttctctaaa tttttctgcc tttaccattt tactcaaatc
    16561 tttattggta gctgatatta ttctaggatt tatttttatt gtggtatctc caccaactct
    16621 tcttatttct ttttcctgta atactctaag caactttgct tgcatactaa gaggtaaatc
    16681 ggcaatttca tctaaaaata cagttccatc ttttgcaagt tcaaatatac ctattcgacc
    16741 ctttttactt gctcctgtaa acgcacctga ttcataccca aaaaactcac tttcaaataa
    16801 ctcatttggt atggcactac agttaacagg tataaattga ccttttctct cactataatc
    16861 atgaatagct cttgcaaata cttctttacc tgtaccactt tcgccccaaa taaatatgct
    16921 actatttgtt ctagccactt gttttgcaat cgctttcgat ttttccaatt tataactttt
    16981 acctaaaatc ttatcaaaac tacctttaga taaatttttg acttcgttct ttagatattt
    17041 taatgtatca tttacttttt caagttcaag agctaatatc ttagcttctg taacatcaac
    17101 ttctgtacat acaacaccga taaattcttc tttataaaat ataggatttg catgaactaa
    17161 tgcatacata ttttcttttt tatctgtaaa atacaagtca ctcattccaa ctttactatt
    17221 tagtactttt tctgaaatag tattttccaa aaattcattc atcggtcgac caactatatc
    17281 ttcagacttt atatcatacc tttcctccat aaacttattc cacaagataa caacaccttc
    17341 gttatttata gcacaaattc cttctttaat ttgacctata atatacttca aagttaatcc
    17401 ataatcttct aaatgcatat atagatagtc cctaatgtgc tcttgtttta gaactccaat
    17461 aattttatta tctctaagaa caggaagaat ccctatattt tttaatatca ttatatctct
    17521 acattcatct aaggttaaac cttcgttgac atatattaca tccttcttca ttataagttt
    17581 tactggttga ccttcatact ttttatgcat ctcataaaga ttatgtatat ccgtcatgga
    17641 tataatgcct tttaattggt cagatgaatc tattaccatt agagtttttg tgttgctttt
    17701 tatcatttct tttattgcat cttcaattct tgtgtcttcg tctatagttg taaattttgt
    17761 atccattacc tcttctactt tttttacttc tggtatcgaa aacataaagt ccccccttta
    17821 tagtagtacc tcatcaaaac ttatttatat atatttattc tagcatatta taataattat
    17881 ttattaaata attattatta aaatttatta agtaattagc atttaaattt atataatcac
    17941 tttaaaattt ataattaaat ttatacaaat gaaatcaaat gaattatacc cttagtatat
    18001 tattttttca atactatttt caccttcaaa acatttttct attcatcaaa caattaatga
    18061 atgcctgtat ccaatcataa atttaagaat ataattaaaa tatatatttt taaacaaact
    18121 atatttgcat attatattta cataaaaaag ccccaaaatg acttataaat caatttgaga
    18181 ctttttattt taaacttaat aataatctag attaatttct ttttatttta cattgatacg
    18241 ctaatccaca aattgcaatg acactaataa atacatatga cattagctga gtttcatcac
    18301 ctgtttttgg tgattttatt attgtatcat ctcttgatag ttctggagtt ttttccactg
    18361 tatcacttac tgatggtact ggtggattta acactgtatc ctctgttggt ggcactggtg
    18421 gatttagcac tgcatcctcc gttggtggca ctggtggatt taacactgca tcctccgttg
    18481 gtggtactgg tggatttatt attgtatcat ccattggtgg tactggtgga tttattactg
    18541 tatcatctat tggtggtgat ggttttggct tatgtccatt tgtatcatct gttggtggca
    18601 ctggtggatt tacaacatca tctgttggta gacctatatt aaagttaact tcttgaccat
    18661 tttttttctc tattgtataa cttaataaat tttgcttact agatggtaat gaagatgaat
    18721 ggtctttttg tcctaaatca agcactgcct tataatattg aatagctttt ggaaaaatat
    18781 aatcataaga tacagcagaa atattagctt tggcatctgg ttttccaaca ctcttaagtt
    18841 taaatttctg ttgcgttgaa atttctactt cgcctgtacc tattatatta ccatctacat
    18901 cataagcagt tactccatct ggtagtttta actttactac accactataa cctactaagg
    18961 ctacagcttc tgtttcataa gtaccatctt catttttttc aaagttaatc ttagttaaac
    19021 cattactcaa actaggtttt cctgtatcat ttggctttaa ctcttcacga cctgctttta
    19081 acaatgcttc taaataagct tttgtattta tcgctacttc tttcctcttc tgatactcag
    19141 ctctttcctc ttcagttttt gctatttcta taagtttatc acaaaggtct atagagcctt
    19201 gatactgctt aagtctttct tgttcatcta tttgtccaag aataatccaa attgcacttt
    19261 gagtagctga gtaagtcatt atgtcatttt cttcttcgcc taaattaaat tgttgcttat
    19321 atccaaatcc atcaaattca gaacctgcat atagtataga tttaactgct tcttcatttt
    19381 ggttttcttg accattaaaa tcttctgctg gtaaatatgg actctttcca ttactacttg
    19441 gtggtcttaa atgattattg taacaaaatg cagtttgctc tccatcttca ccttctatta
    19501 catatttgtc gtcttttgag cttgctccta caagaccctt tattacatag tcaaaagtta
    19561 aagtctttgt aatatcatca aatcttaaat catgataagg tctatctgaa ccatctattt
    19621 cttttagtaa acaagaattt ttcacctttg cttttttgtc ataccataag ctaataaatg
    19681 agtcttctga agtaaaaact tggttaattt ctgattgttc atctgccttt acatcttctt
    19741 catcttccca aaagttatat actattttat ttatttgaga taaagtcata tcaagaattt
    19801 tatcaatatc ttgttttaaa ctcatttcct ctataactat ttcttcttcc aatggttttt
    19861 cttcttctgg aatttgctca tctaatggtt tctccccatc tggcatctga ccatctgatg
    19921 gtttctctac atctggcgtc tgactatctg atggcttctc tccatctggc atctgaccat
    19981 ctgatggttt ctccccatct ggtatctgac catctgatgg tttctcccca tctggtatct
    20041 gaccatctga tggtttctct ccatctggta tctgaccatc tgatggtttc tctccatctg
    20101 gtatctgacc atctaatggt ttctccccat ctggtacctg accgtctgat ggtttctcta
    20161 catctggtgt ctgaccattt gattgttctt ctccattaag tattgtatca ttgctagtca
    20221 cttcgtcagc ataagatact attggtgtaa atgcagtaaa taccatacta aaagcaatta
    20281 ctaaactgat tatacttgat tttttaattt ttgttttcaa aattctcctg atactaaaaa
    20341 catatattgt attcacttaa tataattaaa attattaaat attatatgaa tcttattcaa
    20401 taatacatct ttagtgtgtt caattagggt cgttactcct aaccagttct cctatgaact
    20461 tcttaatatt tctattaagc acagactata tcattaccta accataaatt aggtactccc
    20521 catttcccca cacttgtagg tacgagattt ctctctagtc gttgaagttt cttcttttcg
    20581 aagcttacct gctgattatc cattttcaag gcacttagga tttaacctta tgctatctaa
    20641 ctaatttttt ctactttcgt aacctcaagt gcttattaaa tgcacactct atcacactta
    20701 tccttatttc atgattatgt tgtggtttag ttagctttag gaacttccag caattaaagg
    20761 agttttgggc agatatctgc cactctacac tcgttatgaa tgcagggagc atttcaaaaa
    20821 tatatttata tctatcttct attaattact tatttatgta tttattttat atatttttga
    20881 caattaaaag ttactcctat ttatatttat agcaggttgc actactaact ccatatatct
    20941 tttaagtgcc caggtttaag atatacttca cagtttctat aaataggttt tttaattttt
    21001 cttttttaac tttttaagtg cactttttta acaactcaat aaaatataaa ttagtatcct
    21061 agatacttat ctaataaaag acaaaaatta gtttttataa taaaaaagat actatagagt
    21121 atcttcaaat atcacaaaaa ccttttactc tatcggatag ttgacttaat ataatatgca
    21181 tattaataca aaccacatac ttgagtatca ttatttttgt ccaatattaa ttgtaatagc
    21241 tattgttatc attatacaat atctagcata ttttgtctat tttttccatt tattttacaa
    21301 tatatattgc cctcaaaata cattaaaaaa catctttaga agtaactttt aagttttact
    21361 tctaaagatg tctaacttct atttatctat tattttattt ttaatcttac gtcacctttt
    21421 attcttctta ttaatgggtg attaactgtt ctcattacat ggtcagtaat atgatataca
    21481 cctaatttta attttggtgc agaacccatt actgtgttac tacagtcagt acagtttcct
    21541 attaatataa cttctgctcc agctttctta aattcaatac atttttgagc ttgtcctgga
    21601 cagtgtcctg gattttcaca ttttaatgca cctttaattt cttgagcttg tttacatttt
    21661 tgaactgata ctatatcagt aactcccatt ttagttgcta tatctctcat tctttcttca
    21721 ttaggtccac atgcacaaac taaaagaccc atttttctct tttcattaac aaatggcata
    21781 gtaactatta taccaccact agttttagtt attggagcat ctaaagtagt agctttacca
    21841 gtgaaaggtc ctcctaggat tatttcacca tattcacctt ttattccacc agctctttca
    21901 attaattctc cgacagttgt tccaattggc acatcttcaa acactataga ttcttttcca
    21961 ctgtttaatt gaccaactac agttatattt ttagatataa ctggtctttt ttgctcaaca
    22021 gcctctacta ttctagttag tgtttctacg tttattacta ctgcattagc ctctgaaggt
    22081 aattgagttg gctcaagtaa ttttcctaga acgtctctta ctattgctct ctcttctccc
    22141 attgggtaca tatcaactaa ttctgcaact tctatgttgt ctcctggctt tattactttt
    22201 ttgaaagctt ctattgcttt tggatgctta ctttttattg ctagcatacc ttttccagca
    22261 ttagtaactt ccatagcata ttttatacct tgataaacta tttctggtct ttcttctatt
    22321 tcttttatat tatgagctaa taaaggttca cattcagctg catttgctaa tattgttcca
    22381 ccatttaaat ctatgtttaa ttttacatga gtagggaatc ctgctccacc cattcctact
    22441 actccagctt ctttaattaa gtcaagtata ccttctcctt ttaatggttc aaaagtatct
    22501 tcttgtactt catcagcttc aattactatc gcttggtcat ttatttcact tatttttcca
    22561 ctaacactgg cataaatatt tgcccctaat ccagttggtt ctgcgattag agttcctttt
    22621 tttactacat ctccaacact tactactggc ttatctggac caccaacgtg ttgttttaat
    22681 aaaatagaat atagtttgtt caactagtac gcccccttaa gtatattaat ttttttataa
    22741 gctgttcaaa taatgttaat gctatttttc tattataagg tcttaacata ttgtttattt
    22801 ctatagaaca tatcgcttat taacaaagca atttctatgc caacttttaa acaaacttat
    22861 accctttgga aatactgtct tacagcattc attaattctt ctaaattttt aaacccatca
    22921 aaaaaaagtc aattattaga cactttttta atcaatttaa tctataatta ttgatattgc
    22981 atacatgtat aaaaagtgtc aaaaaataga caccgtcttt ttatcgacac ttttctaaca
    23041 tatactatat aatttatcac aactttactt aaaatataca tttattactt attaattctt
    23101 agttttttgc actccattgg aatcaactac ataattatct ttatacaaca aatcagatat
    23161 tttgactaga ctgtatccat ctttttttag tcgacttatt atagtatcca aatagttatc
    23221 tacatcattt atattagcat ggaataaaac tattgaacca ggttgagatt cttttattac
    23281 tttttcaatt acatgatttg gtccaagctc cttccagtct atagaatcta catcccactt
    23341 aattacttta taacctaaat cactacaaat gtccatagct ttattgttta cgtccccaaa
    23401 aggaggtcta aataaattag tcttttttcc tgttatatta tatatttttt ctgatgtagt
    23461 ttctatctct tttgttatgt cttcttttga tatttccttc aaattggcat gagtgtttga
    23521 atgatttcca atttcatgtc ctttttcatc tatagctttt acaatttctt cattatcatc
    23581 cacccaacta ccaactaaaa agaaggtagc ttttacatta tgtttatcta aaatttttaa
    23641 aatatcatcc atattatcag ttccccatgc tacatcaaaa ctcaaagcta tttttttctc
    23701 atttgtatca actttatata taggcatttt tgaattgtca gatttagaac atatgtattt
    23761 tattccataa acaaaaacaa atattaacac taataataat gaaaaaaata aaacactata
    23821 tatcaaagct ttagtccttt taacttctct tttcatacta ttcccccttt gaaataattt
    23881 cttctatatt taaaatttat tttttttcag ctcaaaaaag tactgtaata tttaatttat
    23941 aagacaataa ctaaaaaaat aaaacctata ttgacctaat taaactctct aaaatactca
    24001 tttatttaat ttttttatat tttttacatt tttaccttta tttttctgta tatattattt
    24061 ttattttgga gaaattagta ttaacatcac ataaataaaa gtgttgttag acatcataaa
    24121 ctaattattt gaggaggaaa tttactatgt caaattcaaa cagaacagta gttccagaag
    24181 caaaagctgc tttaaaccaa atgaaattag aaatagctaa tgaaataggt ttatctaact
    24241 atgaaaacat agacaaaggt aacttaacag ctagagaaaa tggatatgtt ggtggatata
    24301 tgactaagaa attagttgaa atggctgaaa gacaaatggc tggaaaataa atagtaaatt
    24361 ttgacacctg ggtatcaaca gggctgctaa ttagcagccc tgtttctcta tatttattta
    24421 taaaattgtt tttatatgaa ttattaaaga ttaataatac aatacaaatt gttcttttaa
    24481 ttttgtacaa attagtttaa tatattatat atagaaatag tttgacggag gatgatattt
    24541 atgtttgaaa actcgtctga agaattagcc tatcacaaac ttttaatttt atatatatta
    24601 gaaaaaatta aaatggattt aactaattct caaataactc aagtagtatt agagactgag
    24661 atgatgaatt atttttcatt acaacagctt ttatctcagc ttatggaatc taagtttttg
    24721 actacatata aagactctga cagagaatat tatgctctta ctcaaagagg cgtagaaagt
    24781 ctagaatact tctttaatcg aatacctact agtgttactg aaaaaataga caagtatata
    24841 gattctaaca aagaaaatct actagcagat actcaagtaa agtctagttt tgtaaaacaa
    24901 agtgataatg aatttattgt caaccttaga gtcatagaaa atcagtctaa cttaatagat
    24961 ttaaatctaa atgtttcatc agagaaacaa gcaaaactta tttgcaataa ctggaaaaat
    25021 aatgcatctt atatgtatgc cgaagttatc gatttactta taagagacat acattaaagc
    25081 ctacaaacaa attatagttg taggctcttt tcctaccttg atttctttta ttaatttgtt
    25141 atttgcagtt tcataaactt ttactgaatt ttcttgtgta tctgatacaa atagtaactt
    25201 ttcatcttta gatatttcta atccttgggg aatcccattt atttcaatat ttccaatgta
    25261 tctactcgtt gtataatcta aaattcttac attattataa cccaaatcag caacataaac
    25321 ttttttgcca ctataattaa atcttatttc tactggtaat aaaaattcat ataatacctt
    25381 ttttatatcc atgcttactt catctattat tataagcttt ccatcaagtg ttgatatata
    25441 catttctttc ttttgtttat caagttctat atgccaagct ctaaagtcca tatttatttt
    25501 cttttgtata tttttattaa ttgtatctat acatactatc gagtttatac acggtacata
    25561 taactttttg ctttctctat caaagtcaaa tccatgtggc atattatcaa ctccaataat
    25621 tcctattgga tttaatgtgt ttttatctag tacatatata ctattagaat cttcatttgc
    25681 cacaaacaat tcattatcgc taagtacaac ttgactaaga cttcctccta tagagacagt
    25741 atcaattatt ttatcattac ttaaatctaa gacatagagt atcccattac ttgaactagg
    25801 tatgtatatt aaattttttt ctttttctat gcaaaaatgg tgtggatata tattatcttc
    25861 taatactatt tctttttcta gttcaagtgt agaataatca actatgctaa tactctttga
    25921 taagtagtta gaaatataga ttttcatata acccctcctc tctacaatac atatactaca
    25981 ataatatatt atttcattag cttgtattat gctttatagt tgcattatta cgcatatatt
    26041 tggtattatt attaatgtta aaaaaagaaa taatatttaa tggaggtctt tttaatgaaa
    26101 gtaacattta atccaagtgg tgtatgttgt agagaaatga tttttgaagt tgatgaaaat
    26161 aatgtgattg ttgatgctga gtttatagga ggatgtaatg gtaatttatc aggacttaga
    26221 agcttaataa ttggccaaaa tgctcttgaa gttgctgata aattaaatgg tattgactgt
    26281 ggtggaaaag gtacttcttg cccagaccaa ttatctaaag ctatacgtca atctatataa
    26341 ttacttatat aaacatcagt aaaattatta aaaacttatt ttatataaaa agagttgtcc
    26401 attttttaga caactctttt ttatattttt atttgtatac ttattttata aaattataat
    26461 ttctttacta aagttctcac tgtaccaatc atatataatg aacctgcact tattataata
    26521 tcatcctcac ttgatgtttc taatgtataa tttactgcat cctctatctc atgctttgat
    26581 gttacatcat ctacatattt taatactttt tctcttaata tatctgaatt tatggccctt
    26641 gggttatttg gtgttgttgt tattacctta ttaaaatgtg gcaacaatat ctctaaaaca
    26701 ctatcaatat ctttatcttc taacatacct attaataagg ttaattttct acctttaaaa
    26761 ttcttatcaa gtgcttttgc caaagatttt gctccatctt cattatgtgc accatctatt
    26821 ataaaaattg gattttcttt tatcttttct attcttcctg gccatttagt atttataagt
    26881 ccttttctta tagattcttc atttatattt gctaatttat ttatgtcttt tagatatttt
    26941 attacactaa ttgccaagat agaattgttt atttgatgtt cgcctatcaa ttttatttca
    27001 aggtctctat aagtttcttt cattacagta caatcgtata tttgagaatt tatatctgat
    27061 ttttttatgt ttatatcatc aaaatcaact tctatatatt tagctttttt ctctttacaa
    27121 actgacttta taacatcctt tgcttcatca gtctggtcat atactagtac tactccattt
    27181 tcctttatta ttccagcctt ttcgtacgct attttttcta ttgtatctcc aagtatacct
    27241 gtatggtcca aacttataga tactatcaca cttacaagtg attttgttat tatatttgta
    27301 gcatcatatc tgccacctaa accaacttct aatgccacaa agtctacctt ttgttctgaa
    27361 tagtaataaa atgccattgc agtaaccact tcaaattctg tcggatatgc atagccttct
    27421 tttaccataa tctctatttt ttcttttatt aactcaatta ttctagcaac atcatcctgt
    27481 ggtatatttt gtccatttac tcttatacgc tcagtaaaag tttctaaata tggagatgta
    27541 tataaaccaa ctttatatcc acactctctt agtatattag aaacaaaaga acacacagaa
    27601 ccttttccat tagttccagc tacatgtatt atattcaaag tttcttgtgg atttcctaat
    27661 aattctaata actttcctat attttctaat cctaatctta taccgaattt attagtttgt
    27721 gatatgtact ctaatgcttc ttcatatttc attatctaac tccccctgta ttgtcatttt
    27781 ctcttatgct atctaattat agtatatttt ttacttttaa tctaccgaca aagaatacat
    27841 ataatttaat accttctaca ttaaatttag ctacaaatct ttatttataa gtttttatat
    27901 ctttccacta attcagtcag tgtatatatt gaaactaagt catattttga gatgtccata
    27961 taattaaact ttatgtcaaa tctatgctct agctttttca acagattaaa acaattatca
    28021 taaaccaagc ctatctcctt attaaaaagg ctacccttaa agagtttttc attattctct
    28081 tcaatatcta agcaatccct aacaacgtca gcaactttca taaaaagagc attttctttg
    28141 tcatacaaat ccaatttaaa gtttacaatt ctactacact catcaaaatc acaactatcc
    28201 caatgatttc tagttgctaa tgattcaagc ttatcattta aatcagatat tgttatgcct
    28261 ggtttttctg ataatatctt agctatttta ccagtaagct ttgctgataa ataactatta
    28321 cattttggtg gtaatctata ggaattattt atatcacaac ttatatatga attgctatcc
    28381 ataacacatt gaacatcata ttttttatta taccaaaatg aatcatctcc atctaaagta
    28441 aatcctctta cacctataac attgttaaac atagctggat aacttaagtc aaaatcatta
    28501 gcgagtgaac atactattat ttttcctttt ctaaacaatt cataacaaac ttcaaataag
    28561 cccttaacac tttctactcc tatgactgat aaacttaaat taattaatct tatgttagtg
    28621 tctaaaaggt atcttaatgc ttcttcaaga acttttatat ttgtaatacc atcttttctc
    28681 aaaattttta ttacaaataa ctctacatct tcatactctt tctttattat tgatgcacaa
    28741 gcagttccat gaccatcttc atcatcaaat ttatctgata taaagatata atcatgcata
    28801 cattcaaaag caattcctcc aactaaatta tcttttaagt aatcatgttc tttgtctatt
    28861 cctgtatcta atactgcaac cttaacttta ttattcatat cacatatatt ctccattaca
    28921 aaagttttta atatatctat gttaatagtt catcttaaac tttgatttaa gttgcacaat
    28981 ttatctttta aatgctatat ttcttgctaa aaacataaaa taagtacacc atatatttaa
    29041 tttatattta ttatatcaat tattatcatt aaatggttaa atgttaagat aaaattttta
    29101 gatttatatc acaatttaga attatttgta aaaaaggaga ttatcttttt attagacaat
    29161 ccccttgtat attttattaa tatttatcta tgattaagca tcaattttat tttatacttt
    29221 tttattttaa tactatacat ctaaatctta tttaggggga acaattattt atatgctata
    29281 aaaatgctaa tttgaacgaa cttgtcttat aatcagtttt agaaaataca ccattctaca
    29341 aagtatgaat caaaaggtga aaaaatacta aaaataataa atcaacatca attttaatca
    29401 atatatgaaa aacttatacc aagtatgcat aaaaactaat ataaatatta ttttaacaac
    29461 taatacttac acctttatat attatatcat atttcaataa ataaattgca taaaaggaaa
    29521 tcttttcata gaattaaact atttattaat tcattactat aggttcaata aactataaga
    29581 tgtcgcttta atatttatat tgtactccat taaatattaa tataattaat taaagtatgc
    29641 atagctaaat gaaacaaata tctatagagt tttat
//
LOCUS       DAEQCW010000041        29612 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.041, whole genome shotgun sequence.
ACCESSION   DAEQCW010000041 DAEQCW010000000
VERSION     DAEQCW010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 29612)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29612)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29612
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.041"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            53..388
                     /locus_tag="KRO40_001844"
     CDS             53..388
                     /locus_tag="KRO40_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092665.1"
                     /translation="MYNIDDMIYNCPVEALSNILGKKWVAIIIWKIQEDKKRFGELQR
                     AIPDCSKKMLVQQLDFLIEQGIIVNQKKLVNNVVESTYFLSESGLRLLPVMEKMIMWS
                     NKNLNCDKY"
     gene            525..1802
                     /locus_tag="KRO40_001845"
     CDS             525..1802
                     /locus_tag="KRO40_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HBH2092666.1"
                     /translation="MQNVNLFLVFIEGIVSFFSPCILPILPIYLSILSNSSVENLKEG
                     KTSFIGSSLFKNTIFFALGISTTFFILGSSVKVLSMFFNENKDLIMFIGGIIIIIMGL
                     FYMGIIKSSILNREKRFNVKFKEMKAITAFILGFTFSFGWTPCIGPILASVLVMVSSS
                     SNHLSANLLIAVYTIGFILPFIITAMFYSKLFKTIDKIKSNMEIIKKIGGIILIVSGI
                     LMMVNGFGSISKHFNTSQNSKIESKQEENKRENSTDKEENSDGNDSQKDSNNDNNDKG
                     SNDEDRIKSIDFTLTDQYGKTHKLSDYEGKVVFLNFWATWCPPCKEEMPYIEQLYKDY
                     NKNNDDVVILGVASPNLGREGSREHVVNFLKEQGYTFPVVLDEDGALAYQYGINAFPT
                     TFIIDKEGYVTQYIPGAMDKATMASFIENQRNK"
     gene            1923..3311
                     /locus_tag="KRO40_001846"
     CDS             1923..3311
                     /locus_tag="KRO40_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBH2092667.1"
                     /translation="MKKTFDAIIIGFGKGGKTLAGDLANRGLKVALIEKSNKMYGGTC
                     VNVACIPTKSLENSANSVKTKNINSWDEVQAEYEKAIDKKETLITKLREANYNKLNSN
                     ENVTIFTGMGTFIDEKTVQVKTENEIYELVADNIFINTGSRPFIPNIKGIENKNIVYD
                     SESLMNLRVLPKKMTIIGAGFIGLEFAGIYSSFGAEVTILNSNNGILPNEDVEDSEEI
                     IKLLAKRNVKIVNNANIKEIKEVSELAIVEYEVDGKSKELTSNMILVATGRKANTEGL
                     GLENAGIELNERGFIKVSETLKTNKEHIWAIGDINGGPQFTYISLDDYRIVINQLFGD
                     KTRKTNDRKNIPNSIFISPAFSRVGLNVKQAKEKGYEVLVAKMPVEAIPRAKQIGKAD
                     GFIKIVIDKKSNKILGASMICENSSEIIHLIQLAVDLEVEYTYLRDRVYAHPTMTEAL
                     NDILSPNMIKEV"
     gene            3682..4395
                     /locus_tag="KRO40_001847"
     CDS             3682..4395
                     /locus_tag="KRO40_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017208807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF434 domain-containing protein"
                     /protein_id="HBH2092668.1"
                     /translation="MNKISKRGFDDSDKRWFSSKELTRLIKAKEEIEWLLNRDYKIDP
                     VVTFVGDRYQFSIRQRDALKRAVCTDEKNIIRQSKRLSLDKIKEDTVNIDGFNLIISI
                     EVGLSGGTLVIGSDGNIRDLAGLRGTYKIIDKTEEALNLIGKFFNKYNAQNLKFYLDA
                     PVSNSGNLKYRILEHAKTWGIETEVELVKNADVVLEKLDRVVSSDAVIVDKCISYFNV
                     ARGIIEEYIKECNIINLNK"
     gene            4513..5382
                     /locus_tag="KRO40_001848"
     CDS             4513..5382
                     /locus_tag="KRO40_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH2092669.1"
                     /translation="MRGWICVKLTKLNIKKYRAPIYKYALANVNLRSAKSTNSSIITV
                     IPQGAKMEVLDEEDDWIKVMYNSQEGYVYKDLVSVSEYAWSNLNLREDKSTTSNIITV
                     IPEKSRVEVLQVDGDWSKVVYDDKIGYVFNYFLSIDGNKPNELDYKYFYTDMIKFVNE
                     NNIKSTSDYLIVTDLRNKYTYIFKKDNGGWGQLYKWQCTIGKPETPTITGIFYISGRK
                     PSFGTDEYSVKYATRIKGGYYYHSVLYDSTGSYIIDGRLGEALSHGCIRLSTENAKWI
                     YDNIPDTTTVIIH"
     gene            complement(5537..6682)
                     /locus_tag="KRO40_001849"
     CDS             complement(5537..6682)
                     /locus_tag="KRO40_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBH2092670.1"
                     /translation="MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNG
                     TVKKVTDILSQIDIDFVVYDEVKQNPTVTNVNKGLKILKSENCDFVITIGGGSPQDCG
                     KAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMI
                     MVDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAI
                     KQIFKYLPRAVKNGNDIEAREQMCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHG
                     VCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDFVIDKIKALSEEVGI
                     PKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS"
     gene            complement(7015..7791)
                     /locus_tag="KRO40_001850"
     CDS             complement(7015..7791)
                     /locus_tag="KRO40_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBH2092671.1"
                     /translation="MTSDNHRPTARILDILEALAESENGYTLTEIADVINAPKSSIFP
                     IVHTLNARKYITIDKNTSKYSIGIRSYTLGSSFFEKRTIFNYIIDEMTNIVNSCSETC
                     QLGILDNNEVLYIGKVDSPEPIRLISYVGKKIPANCTGLGKALLCDFDKEKLISLYPD
                     GLKGFTEKSITDFDVLYDQLLEVQRTQIASECEESMEHLKCLAVPIRKNGCIRAAVSV
                     TLPLFRANDEKIELIKKLLLNAQKNIQSMMEERNEDIVIN"
     gene            8373..9347
                     /locus_tag="KRO40_001851"
     CDS             8373..9347
                     /locus_tag="KRO40_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBH2092672.1"
                     /translation="MIMDFIKKIPAGMMIVPMFIAAFINTFCPDIVQIGSFTTAVFSS
                     VGSATIIGVQLVCLGTQLQFREMPKVLKRGGILLGSKFAIGALIGILIGKLFGMDGVL
                     GLTTLAVISAVTNSNGSIYLSLMTSYGDETDCATMSLLTLNDGPFFTLIALGTSGLAN
                     VPLLSLLAAIVPILVGMIIGNFDKKMKEFLEPGCNLLVPFVGFALGSSINLASILKGG
                     LSGVLLGLISVFVGGIFIVFCDKFIGKRPGYAGWAVATTAGNAIAVPAAVALVDPSWQ
                     PYVATATTQVAAAVVVTAILVPLITSWWAKKYGCPKFPKQNEDGTITA"
     gene            9445..9750
                     /locus_tag="KRO40_001852"
     CDS             9445..9750
                     /locus_tag="KRO40_001852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH2092673.1"
                     /translation="MINAVIIDEKDNVAVAIEAIAKGSEISFKLKDKTVKTITALDDI
                     TIYHKLAIKDMAKGDKVTKYGEHIGEANQEIKSGQHVHIHNVRSVREDLDKQVMTNI"
     gene            9906..11066
                     /locus_tag="KRO40_001853"
     CDS             9906..11066
                     /locus_tag="KRO40_001853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH2092674.1"
                     /translation="MKFYGYKRPDGRVGIRNHILILPTSVCASDTTRIIASQVQGAVT
                     FNNQNGCSQVHSDQQLTMDVMAGYAANPNVYGVIVVSLGCENCQNDLVVDAIKERTNK
                     PIKTLVIQEEHGTLKTIEKAVRYAREMAQEASLLRKEEFPISELILGTECGGSDPTSG
                     LAANPLIGELSDKLVDLGATSILSETTEFIGAEHILARRAVNEEVKEKILHIVHRYEN
                     SLKLVGEEVREGNPSPGNIAGGLTSLEEKSLGCIHKGGHRQISEVYDYAKQIDKKGLV
                     IMDTPGNDASSVAGMVAGGAQIVVFSTGRGTPSGNPIAPVIKITGNKITFANMEDNMD
                     FDASPVIYGPQTMEELTDDLLNMVVDVANGKQSKAESLGYTEMAIARVCNYV"
     gene            11116..12018
                     /locus_tag="KRO40_001854"
     CDS             11116..12018
                     /locus_tag="KRO40_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBH2092675.1"
                     /translation="MKFVSFTEGENECKRTGVFSKDELFIIDVNSLNLSRNFKDLNEL
                     IQNVSSEDIIKLKTIINESTFYNYDVFKRERCTVHVPIEKPIHDILCVGVNYKDHLEE
                     TQTHFDDSFEEPQKTVYFTKRVTKAIGPEDEIDGHFEINNQLDYEVELGVVIGKTGVN
                     IRKEEVEDYIFGYTVINDISARKLQKEHVQWFRGKGLDTFTSLGPCILHKSAVPFPIK
                     LKVCSRVNGEERQSSNTGLFISDVSDIVSELSKGMTLEAGDIIATGTPSGVGMGFSPP
                     RYMSSGDVVECEIESIGILKNYIK"
     gene            12098..12991
                     /locus_tag="KRO40_001855"
     CDS             12098..12991
                     /locus_tag="KRO40_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HBH2092676.1"
                     /translation="MKAEFLTPVVTIFDEEGNLDKEGNKKVYDHLIDGGVDGLVIMGS
                     TGEFFNMSMDMQKELIDLVTSHVNKRVKVFIGTSRMCINESIELSNYAHNSGADGVMI
                     ISPYYFSLDDDSIELFYSEIAKNTEAEIYLYNYPDRTGYDLSPELTLRLARKHKNIVG
                     YKDTVTLMGHTRDLINTMKIEFPEFKVYSGYDENFIHNLMSGGAGCIGGLSNLIPEVC
                     SKWAEAYNNRDMEKVIEIQKYINKAMDFYLITNPFIPAMKKAMNIRGLQISDYMTAPF
                     VKPNEKQVCEIKKLMNELNIC"
     gene            13697..14170
                     /locus_tag="KRO40_001856"
                     /pseudo
     CDS             13697..14170
                     /locus_tag="KRO40_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014521021.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            14160..15005
                     /locus_tag="KRO40_001857"
     CDS             14160..15005
                     /locus_tag="KRO40_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003485307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092677.1"
                     /translation="MYSKIAIKNVRKSFKDYSIYFLTLTLVICIFYSFNSMESQKALM
                     EMSTSKKPDLEMFKNMISYISVFVSAILCTLILYINNLLIKKRNKKLGIYMTLGMGKI
                     EMSKILVFETIIVGIVSLVSGLILGLLVSQGLLILLLKLFEFNMSEYSFVISIPAIIK
                     TIVYFGIIFLLVMIFNIYLISKYKMIDLLIVERKTEDIKFKNPFVYMITFVSCFIFLF
                     TVYNTTNHIIINLIDDKQLNSKSKGVEINEFTYQDWQQFCDIKYYGKKGLISMTLKEY
                     IEKYK"
     gene            15260..16027
                     /locus_tag="KRO40_001858"
     CDS             15260..16027
                     /locus_tag="KRO40_001858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014521021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092678.1"
                     /translation="MKNILSVEKIEKYYGNKDNITKAIDNISFKVDEGEFVGIMGPSG
                     SGKTTLLNCISTIDNVTIGKIIINNNDITRLKSKNLDKFRQNELGFIFQDFNLLDTLT
                     AYENIALALTIKGEKPSKIDSKIRDVATYLEIEKVIDKYPYQMSGGQKQRVASARAIV
                     TNPSLILADEPTGALDSKSARLLLERFESLNQDLKATILMVTHDAFTASYAHRILFIK
                     DGKIFTELVRGADSRKEFFNRIIEVTTLIGGDDNDVF"
     gene            16017..18011
                     /locus_tag="KRO40_001859"
     CDS             16017..18011
                     /locus_tag="KRO40_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003400181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092679.1"
                     /translation="MYSKIAIKNVRKSFKDYSIYFLTLTLAICIFYSFNSIESQKALM
                     EMNASTKSHVEMLKNMISYMSVFVSVILCSLILYANNFLVKKRNKELGIYMTLGMEKV
                     KISKILVFETIIVGIVSLVSGLILGLLVSQGLSILLLKLFEFNMSEYNFVISISSIIK
                     TIVYFGIMFLLVMIFNTYIISKYKIIDLLTIGRKTEDIKFKSPFVYTITFILCIISLI
                     IAYSMVLKVGLNPKNPKFIMSIVLGVIGTILFFYSLAGFALYIVKKNKNIYFKGLNIF
                     VVKQINSKINTNFISISIICLMLFLTIGILSTGFGFKSALNAGLKGATPFDASATMIV
                     HEKCKVKNIKESFEKVGIKFNKGDKVAYYDEYINGNKLSDVMQGQYSGRVDFEVAYIK
                     SSQYNEIRKLRGEKSITLSKDEVLITSNATEVVPSIEEYMKNNKIIKIDNKAYNIKNK
                     KVIKDNLRTDFTETNALTVVVNDKLCDSMEISSSIVNINFASDNNEKSQENFDKRLKS
                     KYSSTSFYEVGTVSGGSRNAMYNDNNGMTSTILFVGIYLGIVFLISSMAVLALQQLSE
                     ASDSIDRYVSLKKLGASKNSISKTIFTQTLMYFSIPVGLALVHSVVGIQVANNFISRL
                     NKPDIGASSLMTVGILMLVYAVYFYTTYQGYKNIVIKKLN"
     gene            18088..18759
                     /locus_tag="KRO40_001860"
     CDS             18088..18759
                     /locus_tag="KRO40_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005210744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092680.1"
                     /translation="MEKIIIVEDEEVIRDELKSFLERYGYEVMAPTEFDNIVEFILSE
                     KPNLVLLDINLPIYDGYYICRVLRKESNIPIIIVTSRNTDMDELMSMNLGADDFVTKP
                     YKTQILLARIVALLKRSGLNSNVNNTLIFKGIELNLFNATLRYKDKEIELTKNEFKIL
                     SYLVENQGSIVSRDSFMEYLWHTNWFVDDRTLTVNITRLRKKLDEIGIENLIETRRGL
                     GYIIS"
     gene            18756..19763
                     /locus_tag="KRO40_001861"
     CDS             18756..19763
                     /locus_tag="KRO40_001861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003358391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2092681.1"
                     /translation="MRLREYIGDKVVFLGTNLIIFLIASGIMLYSKINVVLIFMLFCI
                     WFLPLFTYMLIDYLQYKKYFNSIDNILDALDKKYLLPEVIDDVNFVTGEKINDILKVI
                     SRNMHENIKYYNDNQEEYKEYIETWVHEIKTPIASSKLIIENNSNEITKKIDTQLDKV
                     ENFVEQVLYYSKIDNVNKDYIIKKLNLEEVVNEVIKRNYRDFINKNIKLELGEINKTV
                     YSDSKWVEFILNQIVVNSIKYIKSKDGLIKISAKRVENSIVLTIEDNGVGIEERDINK
                     VFEKGFTGENGRVFGKSTGIGLYLCKKLCNKLGLGLILESKVNVGTVIKVSFPIDYNL
                     F"
     gene            19928..20323
                     /gene="tnpA"
                     /locus_tag="KRO40_001862"
     CDS             19928..20323
                     /gene="tnpA"
                     /locus_tag="KRO40_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBH2092682.1"
                     /translation="MKLDSNNHSVFLLHYHLVMCIKYRRKVIDDSISDRLKDIFVDIA
                     PNYGVVLIEWNHYVDHVHLLFKAKPNTEISKLLNAYKSASSRRIKNEFPSIRKYLWKE
                     YFWSKSYCLVTTGGATLEDLEQYIENQEE"
     gene            20917..22047
                     /locus_tag="KRO40_001863"
     CDS             20917..22047
                     /locus_tag="KRO40_001863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2092683.1"
                     /translation="MKFKSNVLKQFFLIAMVIFMVGGLIGCSKSDKENKQASTGKKLE
                     LKYASGFSVEDLEDGIKKVTDGDNRELILIPKKIKIPEKYKNANIVRTPVDNVLIAST
                     TQACSLRTIDELDSIKAVTTEEQYWTIKEIKDLMKDGKIHYVGSNLAPDYEKIVDLNP
                     DLTIVSSGLSEADTKFIDKLKELGLNYVVDNEYKEQNPFGRMEWTSLIAAFYDKEDMA
                     TSELNKTVQKVEEVSKKIKNKAKPKVVWASVYEGSAYIAPKDSYVDNMIKMAGGINAC
                     ASIDSNEGRVSIEQLHEVAKDADIFVYSSSSDYAPNLDSIKSSAPVLADLDVVKNGNL
                     WVFAPDYYQSVDKTDELIVDLVEMFHPGTTGEKIKHYINYDK"
     gene            22119..23144
                     /locus_tag="KRO40_001864"
     CDS             22119..23144
                     /locus_tag="KRO40_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH2092684.1"
                     /translation="MDFINKMRIRNTTIFIVLIISMILTFLVCVAFGSVKIEFKEVID
                     VVLRGMDNTEHYKIIYNIRIPRVLATMVGGACLAVSGILLQIFFKNPIVEPYILGVSS
                     GSTLSVALMILGGYTLGFESVNSMSIFVAAFIGALIVMSIVILFANKVKNITTLLIIG
                     IMTGYVCSGITNVLQSFANSDKLKEFTMWSMGSFSGFTWEKVEILIIVGILGLLMTVF
                     IIKPLNAFLLGEEYAKSIGINIRFFRVLIVFISSILAAIVSAFAGPIGFIGLAVPQIS
                     KLIFKTSDNRVLIPVVIFLGSIVTALCDLISRVILSPVELPISTITSLLGAPIVVMLL
                     VKRKDRA"
     gene            23147..24343
                     /locus_tag="KRO40_001865"
     CDS             23147..24343
                     /locus_tag="KRO40_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092685.1"
                     /translation="MLKTNNLSVGYNNKVVISNINVEVKNGEILCLLGSNGAGKTTLL
                     RSLSKLISPIKGEIYLNGVNINCISRKALSKKMALVLTNRLLGDLMTVQDIVNIGRYP
                     YTGFFGSLSKKDLIMVDEALESVDALHLKKRYFDELSDGEKQKVLVARALVQEPEIII
                     LDEPTTHLDIKHRLELINILKKLSKEKSISVILSLHEIDIALKSCDKVALIKNNKVIA
                     YGQPEDVVDEDIINSLYELDDKNFNSLLGSVEISNKSKNEVFIIGGGGKATPIYRAFT
                     KKGIGLYSGIIHENDIDYEIGRTMGIKMFTENPFEPISDESFDLAIRNLNDSKIIIDT
                     GFSVGETNKRNIDIIKEALKLDKKVYSFRNRDESKKYYDSLDNKIEHIDKVSQIINSA
                     DINNLL"
     gene            complement(24471..25196)
                     /locus_tag="KRO40_001866"
     CDS             complement(24471..25196)
                     /locus_tag="KRO40_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH2092686.1"
                     /translation="MKTISKQELEKTLEKHYLWLKNNNAGEKADLKELRLENMDLRGY
                     CLSNIDFSWSDLINLNLEKADLENSIFNNSYLSDCSLKNSILKNADLSGASFRFCDLS
                     NSDIRGANLENSNLEHATLNGVISDESTRFFKLYCPETGAFIGYKKCFNFRMVQLLIP
                     SDAKRVSATSNACRCDKAKVLSITSIDGKESFKSARAYADENFIYRVGETIVAEDFNE
                     NRWKESTTGIHFFLTREEAIGYL"
     gene            25674..27773
                     /gene="nrdE"
                     /locus_tag="KRO40_001867"
     CDS             25674..27773
                     /gene="nrdE"
                     /locus_tag="KRO40_001867"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HBH2092687.1"
                     /translation="MNWIELNNQVIIKNEQGKYQLEKDKEALSSYIEEFIQPKLKKFN
                     NLEERLKYLIDEGYYSKEVINQYSIDVIKNIYDMIDKHKFEFQSYMSANKFYQNYALK
                     SNDGKEILETYNDKVLIVALTLGNGNKDLALNLADKIVKQEFQPATPTFLNAGRKRAG
                     EMVSCFLLSVEDSTEGISYAISSSNHLSKIGGGVALNLSKLRASGESIKDIEGAAGGV
                     VGVAKMLEQSFSYFNQMGARQGSGAVYLTVFHPDFELLMDTKKINADEKIRLATLSLG
                     AIIPDKFMELAEKNEVAYAFYPHTVYKKYGVSLDEIEMDEWYDKLVNDSDIRKKEINP
                     RQMLTKIAQMQQESGYPYVVYIDTANREHTLKDVGIIKMSNLCCEIFQYQTPSEIEGY
                     GGKNEWGQDISCNLGSLNIANVMDNKTIESTVETAIRALSFVADSTDIKPVPTVSNSN
                     SKSHSIGLGAMNLHGYLVRENILYTSDDAIDFSNVFFAMVRYYSIKASMKIAIERNQT
                     FEGFDKSEYVKGRNSKVLSKYYEQSYLPKSEKVRALFEGIYIPTKEDWTKLLDEVKEK
                     GIYNAYLMAVAPTQSISYVQNATSSIMPITEPVEVRTYGDSTTIYPMPFLTNDNMLYY
                     QSAYRMDMRKVIDLVATVQNHVDQGISTTLFVTDEKTTRDIARHYIYAYKKGLKSLYY
                     TRTKMTRDTHECLVCSV"
     gene            27786..28757
                     /gene="nrdF"
                     /locus_tag="KRO40_001868"
     CDS             27786..28757
                     /gene="nrdF"
                     /locus_tag="KRO40_001868"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HBH2092688.1"
                     /translation="MTFNLHKIHNAVNWNREEDGFTQAFWEQNVKQFWLPEEISVSKD
                     IKVWNELSNKEKELYKKVLGGLTLLDTKQGNNGIPSMMSLTENLQRKAVLSFMGTMEE
                     IHAKSYSSIFMTLLSNLEIDELFEWIETEPTLQRKADLVLAQYENTTNQEGLYLSMVT
                     SVFLESFLFYSGFFYPLYLSGQGKMVASGEIISLILRDESLHGKYIGLLAQEIYDSFD
                     KMDKEMLEEKMYSILYSLMENEIEYTNVIYRESGLEKEVVNFLKYNANRALENLGFEK
                     LYTVDAINPIVLNGLSTETKTHDFFSTKGNGYQKGVYEELEDEDFII"
     gene            28833..29459
                     /locus_tag="KRO40_001869"
     CDS             28833..29459
                     /locus_tag="KRO40_001869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH2092689.1"
                     /translation="MKYEWRKRDKELYLPKKNPVIVEIPEQKFIMLKGSGDPNSKEFT
                     EAIGVLYSLAYAIKTMPKKGIVPEGYFDYTVFPLEGIWDKGEKSKGLDVLIKEDLIYT
                     IMIRQPDFVTQDLLDKATDIVKKKKPHNLLEKVRFGSINEGLCVQKLHIGSYDNEPES
                     FDIMNEFCKENKLIRKSYTHREIYISDARKVSPESLKTVLRFEVEREV"
BASE COUNT        11714 a         3116 c         5031 g         9751 t
ORIGIN      
        1 attgctataa aagtttgttt aataaattaa ataaagaaaa gaggagaata aaatgtacaa
       61 catagatgat atgatatata attgtccagt agaagcttta tcaaatattt taggtaaaaa
      121 atgggtggct ataattatat ggaaaataca agaagataaa aaacgatttg gagagctaca
      181 aagagctata ccagactgta gtaagaaaat gttagttcaa caactagatt ttttaattga
      241 acaggggatt atagtcaacc aaaaaaagtt ggttaataat gttgtagagt caacatattt
      301 tttaagtgaa tcaggattac gattgcttcc tgtcatggaa aaaatgatta tgtggagcaa
      361 taaaaattta aattgtgata aatactaaaa tttactctgt aagtaatgaa aatttaatta
      421 agctatgagt agaaaaatgt attaaaatta cataattttt tagttagatt ttaatttaga
      481 aatgggattg taatattgga aataaaataa ggaggaattt taatttgcaa aatgtaaatt
      541 tatttttagt atttatagaa ggtatagtat cattcttttc accatgtata ctgccaattt
      601 tgcctattta tttgagtata ttgtcaaata gtagtgtaga aaatttaaaa gaaggaaaga
      661 cgagttttat aggaagttct ttatttaaaa atactatatt ttttgctctt ggaatctcaa
      721 caacattctt tatattgggt tcatcagtaa aagtattgag tatgtttttt aatgaaaata
      781 aagatttaat aatgtttatt ggtgggatta taattattat catgggatta ttttacatgg
      841 gaataattaa atcttcaata ttgaatagag aaaaaagatt taatgttaag tttaaagaaa
      901 tgaaagcaat aacagctttt atattaggtt ttacgtttag ttttggatgg acaccttgta
      961 ttggtccaat attggcatct gtattagtca tggtttcaag ttcaagtaat catcttagtg
     1021 ccaatctttt aatagcagta tatactattg gttttatttt gccattcata attacagcta
     1081 tgttttacag taaactattt aaaactatag ataagataaa atctaatatg gaaattatta
     1141 aaaaaatagg tgggattata cttatagtat caggaatatt aatgatggta aatggatttg
     1201 gaagtataag caaacacttt aatacgtcac aaaatagtaa aattgaaagc aagcaagaag
     1261 aaaataagcg agaaaattct actgataaag aagaaaattc tgatggtaat gatagtcaaa
     1321 aagactctaa taatgacaat aatgataaag ggtctaatga tgaagataga ataaagtcta
     1381 ttgattttac tttaacagac cagtatggta aaacacataa attaagtgat tatgaaggca
     1441 aagttgtatt cttaaatttc tgggctacat ggtgtcctcc atgtaaagaa gaaatgcctt
     1501 atatagaaca actgtataaa gactataata aaaataatga tgatgtagta attttaggag
     1561 tagcttcacc taatttaggt agagaaggtt caagggaaca tgtagttaac ttcttaaaag
     1621 aacaaggtta tacattccct gttgtacttg atgaagatgg agcattagca tatcaatatg
     1681 gaattaatgc ttttccaact acatttataa ttgacaagga aggatatgta actcagtata
     1741 ttccaggagc tatggataag gcaactatgg catcatttat tgaaaatcag agaaataaat
     1801 aaaagtattt aagtataagt ttataaatca atttaaggtt acaaaaaagt gcctaattgt
     1861 accacctaaa taatcttgtt atagtaaaag tataaacaat acaagaaagg gttgaatttt
     1921 atatgaaaaa aacatttgat gctataataa taggatttgg aaaaggtgga aaaacattag
     1981 caggggattt ggcaaacagg ggattaaaag tagctttaat agaaaagtca aacaagatgt
     2041 atggtggaac atgtgtaaat gtggcatgta taccaacaaa aagcttagaa aattcagcaa
     2101 acagcgtaaa aacaaagaat ataaattctt gggatgaagt acaagctgaa tatgagaaag
     2161 ctatagataa aaaagaaact ttaattacaa aactcagaga agctaactat aataaattaa
     2221 attcaaatga gaatgtaact atattcacag gaatgggaac tttcattgat gaaaaaacag
     2281 ttcaagtcaa aactgaaaat gaaatttatg agttagtagc agataatata tttattaata
     2341 ctggttcaag accatttata cctaatatta agggaattga aaataagaat atagtatatg
     2401 atagtgagtc tcttatgaat ctaagagttt tacctaaaaa aatgacaatt ataggagctg
     2461 gatttatagg tttagaattt gctggtattt atagttcatt tggagcagaa gttacaatat
     2521 taaactctaa taatggcatt ttaccaaatg aagatgttga ggattcagaa gaaataataa
     2581 aattacttgc aaagagaaat gtaaaaattg ttaataatgc aaatataaaa gagattaaag
     2641 aagtttctga attagcaata gtagaatatg aagtagatgg taaatctaaa gaattaacaa
     2701 gtaatatgat acttgtagct acaggaagaa aagcaaacac tgaagggcta gggctagaaa
     2761 atgcaggtat agaattaaat gaaagaggat ttattaaagt ctcagaaact cttaagacta
     2821 ataaagagca tatatgggct ataggagata taaatggagg tccacaattt acttatattt
     2881 cattggatga ttatcgcata gttattaatc agttatttgg agataagact agaaaaacta
     2941 atgatagaaa gaatatccca aattctatat ttataagtcc agcattttca agagttggtc
     3001 ttaatgttaa gcaagctaaa gaaaagggat atgaagtatt agtggcaaag atgccagtag
     3061 aagcaattcc aagagctaaa cagattggca aggcagatgg gtttataaaa atagtgatag
     3121 ataaaaaatc caataagata cttggagcta gtatgatatg tgaaaattca agtgagatta
     3181 tccatcttat tcaattagct gtagatttag aagtagagta tacatattta agagaccgtg
     3241 tttatgcaca tccaactatg acagaagctc ttaatgatat tctatctcct aatatgataa
     3301 aagaagtata acataagttt aatatataaa cctaaaatta tcattataag tagattttag
     3361 aaagagacta tctcaaaaaa tagagataag tctctttttt actgtttaaa taataaaaat
     3421 atatttgatt ttataaaaga agattatttt atgagctaaa aagtttattt agaaacacta
     3481 cctatttatg ttataaagtt ataaatataa tatagaatct attattctgt attattaagt
     3541 ggggttaagc gttataatta attataaata ttgaataatc taaatggata agataatggt
     3601 attaaaaatt atcttaaaag gtgaaataat ctgtatttaa tgtagtacag ttatatcttt
     3661 aaagcaaggt ggtgaaatga tataaataag atatctaaaa gagggtttga tgatagtgat
     3721 aaaagatggt tttcaagtaa agaattaaca agacttataa aggctaaaga agaaatagaa
     3781 tggttattaa atagggatta caaaatagac ccagtcgtta cttttgttgg tgatagatat
     3841 cagttttcta taagacaaag agatgcatta aaaagagcag tctgtactga tgaaaaaaat
     3901 attataagac aatcaaagag gctttctcta gataaaatca aagaagatac cgtaaatata
     3961 gatggcttta atttgataat atccatagag gtaggattat ctggtggtac tctagtaata
     4021 ggaagtgatg gcaatataag agatttagca ggtcttaggg gaacctataa gattatagat
     4081 aaaacagaag aagctttgaa tctgataggt aaatttttta ataaatacaa tgcacagaat
     4141 cttaaatttt atttagatgc tccagtttct aattcaggaa atttaaagta taggatatta
     4201 gagcatgcca aaacttgggg aattgaaact gaagtagaat tagtaaaaaa tgcagatgtt
     4261 gtattggaaa aattagatag agtagttagt agtgatgcag tcatagttga caagtgtata
     4321 agttatttta atgtggctag aggtataatt gaagagtata ttaaagaatg taatatcata
     4381 aatttaaata aatagataaa tataggtgag aatatataag tatatgtagc aatattctta
     4441 gtaatacaag taaagtttga aaataggaga acgaatacat atcgaatttc ataaaatgtt
     4501 gtaaaaagac atatgagagg atggatatgt gtgaaattaa ctaaactaaa tattaaaaaa
     4561 tatagagcac ctatatataa atatgcttta gcaaatgtaa atttgaggtc tgctaaatct
     4621 actaattcaa gtatcataac agtaatacct cagggagcca aaatggaagt attggatgaa
     4681 gaagatgact ggattaaggt gatgtacaat tctcaagaag gatatgtgta taaggatttg
     4741 gtatcagtaa gcgaatatgc ttggagtaac ttaaacttaa gagaagataa atctacaact
     4801 tccaatataa ttacagtaat tcctgaaaaa tctagggttg aagtccttca agtagatgga
     4861 gattggagta aggttgtata tgatgataaa ataggatatg tttttaatta ttttttatca
     4921 attgatggga ataaaccaaa tgaattagat tataagtatt tttatactga catgattaaa
     4981 tttgttaacg aaaataatat taaaagtact agcgattatc taattgtaac agaccttaga
     5041 aataaatata cttatatttt taagaaagat aatggaggtt ggggacaact ttacaagtgg
     5101 caatgtacta taggcaagcc tgagactcca actataacag gtatatttta tataagtgga
     5161 agaaaacctt cttttggaac ggatgagtat tcagttaagt atgctactag aattaaaggt
     5221 ggatattact atcattctgt actatatgat tcaacaggaa gttatataat agatggcaga
     5281 cttggtgaag ctcttagtca tggatgtata agattaagta cggaaaatgc aaagtggata
     5341 tatgataata taccagatac aacaacagtt ataattcatt aagaaaaatt ttgagttttt
     5401 tattgggata atgattctta aattaatagg attatatatt aacttctcat aaagagtact
     5461 atttaaaaag tgtaataaga gagtgctatt aacaaaacaa agatattttg aggcactctc
     5521 ttataaatat acataattaa gatattttca taaacaattc tataatctta tctttatcaa
     5581 agaaaacagg attagcacca gcacaagcat ctttcataga gttttctgca agcaattcaa
     5641 aattaggatt atcaacacct acatctttta aagattttgg gattccaacc tcttcagaaa
     5701 gagcttttat cttatctatt acaaagtcaa cacactcttt atctgattta ttatttacat
     5761 ccattccaat aacttcagct attggtcgga atttggcagg ggctgattta gcattttcct
     5821 cctcaactat tggaagtagc atggcattac atactccatg aggtaaatca tataaacctc
     5881 ctaattgatg agccatagca tgtacatttc caagacctgc attactaaag gcaattccat
     5941 ttaaaaaaca agcataacac atttgttctc tagcttctat gtcattacca tttttaacag
     6001 ctcttggaag gtatttaaat atctgcttta tagcatataa ggcagttgaa tctgtaacat
     6061 cataagcacc attagctact acagcttcta tagcatgagt tagtgcatcc ataccagttg
     6121 ctgctgttaa attagatggt ttgctaatca ttaattctgg gtcatttact gtcattgtgg
     6181 ctagtgaatt ggtatcaacc attatcatct ttacatgtct gtcttcatca gttataacat
     6241 agtttattgt aacttcagca gatgtaccag cagtagtagt tatagctatg ataggaagac
     6301 attttttaga agttttgttg ataccttcat agtctctaat atctcctcca ttagtggcta
     6361 atatagagat agctttacca cagtcttgtg gagaaccacc tcctatagtt ataacgaagt
     6421 cgcaattttc tgattttaat attttaagtc ctttattcac attagttaca gttggatttt
     6481 gtttaacttc atcataaaca acaaagtcta tatctatctg agataaaata tctgttactt
     6541 tttttacagt accatttgaa actagaaatt tatcactaac aataaatgct tttttagttc
     6601 ctaatgattt aattgaatct ttagcttcat taagacatcc tttcccaagt aaatttattg
     6661 gtggtacata ataaatgctc ataactaaaa tctcctttta ttttcattga tttttatgta
     6721 aaaatatata tctaacaatt ttcactaatt tactcataat atatcgtatc ttagattgag
     6781 atagggttgc tggttcttat ataagaactt aattcgtaat tacgattatg attagaattt
     6841 aacatagtat ttttatcatg tcaataaaaa tataaaaaat attataaaaa aaacaaagtt
     6901 actgtagtta aatcagcaac tttgttttta tagtataaat caaataaata cattagttta
     6961 aaacaaaatt tttaattatt atgttttgat atcttccata tacagaatat taatctaatt
     7021 tattacaatg tcttcattac gttcttccat cattgattga atatttttct gagcatttaa
     7081 gagtaatttt tttatcagtt ctattttttc gtcattagct ctaaataaag gcagtgttac
     7141 actaacagca gctcttatac atccattttt tcttattggt acggcaagac attttaggtg
     7201 ttccattgat tcctcacact ctgaagctat ttgtgttctt tgaacttcaa gaagctggtc
     7261 gtataaaaca tcaaaatctg taattgattt ttctgtaaaa ccttttagac catctggata
     7321 taagcttatt agtttttcct tgtcaaaatc acataaaaga gcttttccaa gacctgtaca
     7381 attagcaggt attttttttc caacataaga aataagtcta atcggttctg gagaatctac
     7441 ttttccaata taaagaactt cattattgtc aagtatacca agctgacaag tttcagaaca
     7501 ggaattaact atattagtca tttcgtcaat tatatagtta aaaatagttc ttttttcaaa
     7561 aaatgaagac cctaatgtgt aagaacgtat ccctatagaa tatttggatg tgtttttatc
     7621 aatagtaatg tattttctag cattaagtgt atgaactata ggaaagatgc tactttttgg
     7681 agcattgata acatctgcta tttctgtaag agtatatcca ttttcggatt ctgctaatgc
     7741 ttctaaaata tctaatatcc tagctgttgg gcgatgatta tctgaagtca taaatttccc
     7801 cctcttttta ttaatttaaa gtattagaat atgttgattt tagcacacta tacgatattt
     7861 tacaatgtag aaaataaata tgtaaattta tatataaata agctcttgat ttagatacag
     7921 atagatattt ttttagactg tacattaagg aataactaat ttccaaaata tacctaaaga
     7981 aagtaagtga tatttagtta tataatttaa gtaaatatat gcaatagtta tttttatatg
     8041 taaatatcaa aatattatga acttatattt tatctatttt ttacactgta taaaaacttt
     8101 atagttttga atactatata attttaaata cgctgtattt ttgcatataa ggaagtcatt
     8161 tgataatata caaggtatta tcagaaagtt tgaaaaaatt ttgacaaaaa tttatttttt
     8221 ttattgactc ataaatagga aaatgctatc attaattcaa agattcgtaa ttaaaaactt
     8281 agttcttaaa tacgaaccga aacggccgtt agaattaaag ctaaaaactt aataagagta
     8341 attaaatatc atgttttagg aggattaact ttatgataat ggattttatt aaaaaaattc
     8401 ctgcaggtat gatgatagtg ccaatgttta tagcagcttt cattaatacc ttttgcccag
     8461 atattgtaca aataggttcg tttacgacag cagtattttc aagtgttggg tctgcaacta
     8521 taattggggt tcaactggta tgcttgggaa ctcagcttca atttagagaa atgccaaaag
     8581 ttttaaagag aggtggtata cttcttggtt ctaaatttgc tataggtgct ttgataggta
     8641 tacttatagg aaagctattt ggaatggatg gtgtccttgg tctgacaaca ttggctgtta
     8701 taagtgcagt tacaaatagt aatggtagta tatatctttc attgatgact tcatatggag
     8761 atgaaacaga ttgtgcaact atgagtttac ttactttaaa tgatggacca ttttttacat
     8821 taatagctct tgggacttca ggtcttgcaa atgtaccatt gttgtcatta ttggctgcaa
     8881 tagtgccaat acttgttggt atgataatag gaaattttga caaaaaaatg aaagagtttt
     8941 tagagccagg gtgtaattta ctcgtacctt ttgtagggtt tgcacttggt agtagcataa
     9001 atcttgcaag tatactaaaa ggaggtttat caggagtatt acttggatta atatctgtat
     9061 ttgtaggagg tatatttata gtattctgtg ataaatttat aggaaaacgt ccaggatatg
     9121 caggatgggc tgtagctaca actgctggaa atgcaattgc tgtacctgct gctgttgcat
     9181 tagttgaccc atcatggcaa ccatatgttg caacagctac aacacaagtg gcagccgcag
     9241 tagttgtcac tgcaatatta gtacctctta taactagttg gtgggctaag aagtatggat
     9301 gtcctaagtt cccaaaacaa aatgaggatg gtacaataac agcttaattt atattacagt
     9361 gagttgttgg taaaataata aattctttaa ttagatttta ggatattaat aaaattatat
     9421 tatttataaa ggagagcaag aataatgata aatgcagtga taattgatga aaaagataat
     9481 gttgcagtag ctattgaagc aatagctaaa ggtagtgaaa ttagttttaa attaaaagac
     9541 aaaacagtaa aaacgattac agcactagat gatataacta tttatcataa attggctata
     9601 aaagatatgg ccaaaggtga taaagttact aaatatggtg aacatatagg agaagcaaat
     9661 caggaaataa aaagtggcca acatgtacat attcataatg ttagaagtgt tagagaggat
     9721 ttggataaac aagttatgac taatatataa aataatattt atagagttat aaaagttgta
     9781 ttcattgctt ttagtgtcaa atagttttta aataggtttt tagctgtttg attagtgagt
     9841 gtaataaaaa ttataatata taaaaattat agaaagtata tagactattt taggaggaaa
     9901 tcagtatgaa attttatgga tataaaagac cagatggaag agttggtata agaaaccaca
     9961 tattaatatt gcctacgagt gtgtgtgcat cagatacaac tagaataata gcatcacaag
    10021 ttcaaggggc agttaccttt aataatcaga atggatgttc acaagtacat tcagaccaac
    10081 aattaactat ggatgttatg gctggttatg cagcaaatcc aaatgtatat ggtgtaatag
    10141 ttgtatcttt gggatgcgaa aattgccaaa atgatttggt agttgatgca ataaaagaga
    10201 gaacaaataa gccaataaaa actcttgtaa tacaagaaga acatggaact ttaaaaacta
    10261 tagaaaaagc tgttcgttat gctagagaaa tggcacaaga agcttctttg cttagaaaag
    10321 aagaatttcc aatatctgaa cttatactag gaactgaatg tggtgggtct gacccaacaa
    10381 gtggattagc agcaaatcca ttaataggtg aattaagtga taaacttgtc gatttaggag
    10441 caacatcaat tttaagtgaa actactgaat ttataggtgc agagcatata ctagctagga
    10501 gagcagtaaa tgaagaagta aaagaaaaaa tattacatat agtacataga tatgaaaatt
    10561 cattaaaatt ggttggagaa gaagttagag aaggtaatcc atctcctgga aatatagctg
    10621 gtggtttaac aagtttagaa gaaaaatcac ttggttgtat acataaaggt ggtcatagac
    10681 aaataagtga agtatatgat tatgccaaac aaattgataa gaaaggtctt gttataatgg
    10741 atacccctgg aaatgatgct tcatctgttg ctggtatggt agcaggagga gcacaaatag
    10801 tggtatttag tacaggaaga ggaacaccat caggaaatcc aatagcacca gtaataaaaa
    10861 taactggaaa taaaataact tttgcaaata tggaagataa tatggatttt gatgctagtc
    10921 cagttatcta tggtccacaa acaatggaag aattaacaga tgatttgtta aatatggttg
    10981 tagatgtagc aaatggaaaa caatcaaaag cagagtccct tggatatact gaaatggcaa
    11041 tagctagagt atgcaactat gtataatctt taagtaagaa aataaataca tagaatttta
    11101 ataaagggtg agattatgaa gtttgtaagt tttactgaag gagaaaatga atgtaaaaga
    11161 actggagttt tttctaaaga tgaattattt attatagatg ttaactcttt aaatctcagt
    11221 agaaatttta aggatttaaa tgaattaatt caaaatgtat ctagtgaaga tattattaag
    11281 ttgaaaacta ttataaatga aagtacattc tataattatg atgtttttaa aagagagaga
    11341 tgtacggtac atgttcctat agaaaaacca atacatgata tcttatgtgt gggagtgaac
    11401 tataaagacc atcttgaaga aactcaaact cactttgatg atagttttga agaaccacaa
    11461 aaaacggttt attttacaaa acgtgtgaca aaggcaatag gtccagaaga tgagatagat
    11521 ggtcattttg agataaataa tcaactagac tatgaagttg aacttggagt agtaataggt
    11581 aaaacaggtg ttaatattag aaaagaagag gtagaagatt atatctttgg ttacactgtt
    11641 ataaatgata tttctgctag aaagttgcaa aaagaacatg ttcaatggtt tagaggaaaa
    11701 ggattagata catttacctc tttaggtcca tgtattttac ataaaagtgc agttcctttt
    11761 cctataaaac ttaaagtatg tagtagggta aatggtgaag aaagacaaag ttctaataca
    11821 ggattattca tatcagacgt ttcagacata gtttcagaac tttcaaaagg tatgacctta
    11881 gaggctggag acattatagc tactggaaca ccttctggag tagggatggg attttcacct
    11941 cctcgatata tgagtagtgg agatgtagtt gaatgtgaga ttgagagtat tggaatttta
    12001 aaaaattaca ttaagtaact gttttaatat aattaatatt aaagctaaat ctgatgtatt
    12061 aatgaacata ttaaaataaa ttttaggagt ttaaattatg aaagcagaat ttttgacacc
    12121 agttgttaca atatttgatg aagaaggaaa tttagataaa gaaggtaata aaaaagtgta
    12181 tgaccatctt atagatggag gtgtagatgg actagtcata atgggaagta ctggagagtt
    12241 ctttaatatg tctatggata tgcaaaaaga acttatagat ttagtaacta gtcatgtaaa
    12301 taagagagta aaagtgttta taggtacaag tcgtatgtgt ataaatgaat ctatagaact
    12361 ttcaaactat gcacataata gtggagcaga tggtgttatg ataataagcc cttattattt
    12421 ctctcttgat gatgatagta ttgagttatt ttatagtgaa atagctaaga atacagaggc
    12481 tgaaatatat ttatacaatt atccagatag aactggttat gatttaagtc cagaacttac
    12541 attaagactt gcaagaaaac ataaaaacat agttggatat aaggatacag taactttgat
    12601 gggacatacc agagatttaa taaatactat gaaaatagag ttcccagaat ttaaggttta
    12661 tagtggttat gatgaaaact ttatacataa tctaatgtct gggggagcag gttgtatagg
    12721 ggggttatca aatttaattc cagaagtttg ctccaaatgg gctgaagctt acaataatag
    12781 agatatggag aaggttatag aaattcaaaa atatattaat aaagcaatgg atttttactt
    12841 aataaccaat ccatttatac cagcaatgaa aaaagctatg aatatcagag ggttacaaat
    12901 aagtgattat atgactgctc catttgtaaa accaaatgaa aaacaagtat gtgaaattaa
    12961 aaaattgatg aatgaattaa atatatgtta acttactaag taagatatat gagcaaaaaa
    13021 agagtgttta aactgatttt tataatcatt ttaaacactc tttttatata tgttaaatca
    13081 actttgaaaa gtggtcaaca ataaattaca attatgttaa taaaaattaa ataatactaa
    13141 gatagcagat tagtttaaaa gttagcacaa atattaaagc aatagccttt atctattaaa
    13201 aataatcttg gagttttaca aacattttta gataagtata agttaacaat aagagccaca
    13261 tataaactac tacaaatcat gtaataatta atctaataaa tgataaacac ttagacttca
    13321 agcttaaaag tataaagata aatgaattta catatcaaga ttggcaataa ttttgtgata
    13381 caaagcacta tagtaagaat gatttaatac caatgatttt gaaagaacat atagaaaaat
    13441 acaattagaa taaaataaat tttagaggga aggcattgcc ttccattttt tgtgtttttc
    13501 tagaattggg taaattttac gattctagta aagcacaaaa gaaaatctgt tggtcttgaa
    13561 cattttatat tagtaattat aggtagcaat atacaattac tacaaaagtg aaatattaat
    13621 gaaatgtaaa tcaatttaaa aaaattaaat taaaaattac aatagatata taagaaattt
    13681 aaaggagaaa taaggcatga aaaatgtatt aagtgttgaa aaatggaaaa gtattatgaa
    13741 aacaaagata atattacaaa agcaatagat aataatgata ttacaagatt aaaattcaaa
    13801 aacttagata aatttagaca aaatgaatta ggatttatat tccaaaattt taatctttta
    13861 tatactttaa cagcttatga aaatatagca ttgacattaa caattaaagg gaaaacaata
    13921 taaatttgat tcaaaagcat caagattatt acttgagagt tttgaaagtt taaatcaaga
    13981 tttaaaaaca acaattttaa tgctaactaa tgatgctttt atagctagtt atactcatag
    14041 aaacttattt ataaaataca gaaaaatatt tatagagtta gcaagacgaa ctgattcaat
    14101 aaaagagtct tttaatagaa taattgaaga aatagctata atcagaggag atgataacaa
    14161 tgtattctaa aatagcgatt aaaaatgtta gaaaaagctt taaggattat agtatatatt
    14221 ttttaacttt aacattagta atttgtattt tctatagttt taactctatg gaatctcaaa
    14281 aagctttaat ggaaatgagt acttcaaaaa agcctgattt agaaatgttt aagaatatga
    14341 tttcatatat atctgtgttc gtatcagcta ttttatgtac tttaattctt tatattaata
    14401 acttattaat caaaaaaaga aataagaaac ttggaattta tatgacttta ggaatgggaa
    14461 aaattgaaat gtcgaaaata ttagtttttg aaactataat agttggaata gtctctttgg
    14521 taagtgggct aatacttgga ttattagtat ctcaagggtt attaatacta ttattaaagt
    14581 tatttgaatt taatatgagt gaatatagct ttgtaatatc aataccagca attattaaaa
    14641 ctattgtcta ttttggaata atatttttac ttgtaatgat atttaatatc tatttaattt
    14701 ctaaatacaa aatgatagat ttattaattg tggaaagaaa aacagaggat ataaaattta
    14761 aaaatccatt tgtatatatg attacatttg tatcatgctt tattttctta tttactgtat
    14821 ataacactac aaatcatatc ataattaatc taatagatga taaacaatta aactccaagt
    14881 ctaaaggtgt agaaataaat gaatttacat atcaagattg gcaacaattt tgtgatataa
    14941 agtattatgg aaagaaaggt ttaatatcaa tgactttaaa agaatatata gaaaaataca
    15001 agtagaataa aataaatttt agatggaagg cattgccctc tatatttttg tgttttctag
    15061 aattgagtaa attttgttac tctagcaaag tataaaagaa agaatgctgg tcttgagtat
    15121 tttatattag taattattag ggaataatat ataattacta caaaaatgaa acattaatga
    15181 aatgtaaatc aatttaaaaa aattaaataa aaaattacaa tagagatata agaaaattaa
    15241 tttaaaggag aaatagaaca tgaagaatat attaagtgtt gaaaaaatag aaaaatatta
    15301 tggaaacaaa gataatatta caaaagcaat agataatata agctttaaag ttgatgaagg
    15361 agaatttgtt gggataatgg gtccaagtgg tagtgggaag acaacacttc ttaactgtat
    15421 atcaacaata gacaatgtaa caataggtaa aataataata aataataatg atattacaag
    15481 attaaaatct aaaaacttag ataagttcag acaaaatgaa ttaggattta tattccaaga
    15541 ttttaatctt ttagatactt taacagctta tgaaaatata gcattggcat taacaattaa
    15601 aggagaaaaa ccatctaaaa ttgattcaaa aataagagat gtagctacat acttagaaat
    15661 agaaaaagtg atagataaat atccttatca aatgtcagga ggacaaaagc aaagagtagc
    15721 atcagctaga gcaatagtta ctaatccatc attgattttg gcagatgaac ctacaggagc
    15781 acttgactca aaatcagcaa gattattact tgagaggttt gaaagtctaa atcaagactt
    15841 aaaagcaaca attttaatgg taactcatga tgcttttaca gctagttatg cccatagaat
    15901 cctatttata aaagacggaa aaatatttac agaattagta agaggagctg attcaagaaa
    15961 agagtttttt aatagaataa ttgaagtaac aactctaata ggaggagatg ataacgatgt
    16021 attctaaaat agcaattaaa aatgttagaa aaagctttaa ggattatagc atatattttt
    16081 tgactttaac attagcaatt tgtattttct atagttttaa ctctatagaa tctcaaaaag
    16141 ctttaatgga aatgaatgct tcaacaaaat ctcatgtaga aatgcttaag aatatgattt
    16201 catacatgtc tgtatttgta tcagttattt tatgcagttt aattctttat gctaataact
    16261 tcttagtcaa aaaaaggaat aaggaacttg gaatttatat gactttaggg atggaaaaag
    16321 ttaaaatatc gaaaatatta gtttttgaaa ctataatagt tggaatagtt tctttagtaa
    16381 gtggactaat acttgggtta ttagtatctc aagggttatc aatattatta ttaaagttat
    16441 ttgaatttaa tatgagtgaa tacaattttg taatatcgat atcatcaatt attaaaacta
    16501 ttgtctattt tggaataatg tttttacttg tgatgatatt caatacttat ataatttcta
    16561 aatataaaat aatagattta ttaacaatag gaagaaaaac agaggatata aaatttaaaa
    16621 gtccatttgt atatacaatt acatttatat tatgcattat ttccttaatt attgcatata
    16681 gcatggtttt aaaagttgga ttaaatccta aaaatcctaa gtttattatg tcaatagtat
    16741 taggtgtaat tggaactata ttattcttct atagtttagc aggctttgca ttatatattg
    16801 ttaagaagaa taagaacatt tactttaagg gattaaacat atttgtagta aagcaaataa
    16861 atagtaagat taatacaaac tttatatcaa tatctattat ttgtttaatg ttatttttaa
    16921 caataggaat actatcaaca gggtttggtt ttaaatcagc tttaaatgca ggactaaaag
    16981 gtgcaactcc atttgatgca agtgcaacca tgattgtaca tgaaaaatgt aaagtgaaga
    17041 atataaaaga atcttttgaa aaggttggaa ttaagtttaa taaaggtgat aaagttgctt
    17101 actatgatga atatataaat ggtaataaac tttcagatgt tatgcaagga caatattctg
    17161 gtagagtgga ctttgaagta gcatatataa aatcttcaca gtataatgaa ataagaaagt
    17221 tacgaggtga aaagtcaata actttatcaa aagatgaagt attaataaca tctaatgcta
    17281 cagaggtagt accttcgata gaagaataca tgaaaaataa taaaattata aaaatagata
    17341 ataaagcata taatataaaa aataaaaaag taataaaaga taatttaaga actgatttta
    17401 cagaaacaaa tgctcttact gtagttgtaa atgacaaatt gtgtgatagc atggagatat
    17461 cttcaagtat agtaaatata aacttcgctt cagataataa tgaaaagtca caagaaaatt
    17521 ttgataaaag gctaaaatca aagtatagtt ctacaagttt ttatgaagtt ggaactgtat
    17581 caggtggatc aagaaatgct atgtataatg ataataatgg tatgacttct acaatactat
    17641 ttgttggaat ctatttagga atagtatttt taataagtag tatggcagtc cttgcacttc
    17701 agcaattaag tgaggctagt gatagtatag atagatatgt atccttaaaa aaactaggag
    17761 caagtaaaaa tagtataagt aaaactatat ttacacaaac tctaatgtac tttagcatac
    17821 ctgttggact agctttagtt cactcagtag taggaataca agtggctaat aattttatat
    17881 caaggcttaa taagccagat ataggagctt catcacttat gacagtagga attttaatgt
    17941 tagtatatgc agtgtatttt tatacaactt atcaagggta taaaaatata gttataaaaa
    18001 agcttaatta atacaactaa ctaaaatctg tttacagtaa aaatcatact gtaaatagat
    18061 tttttgaaaa taaagggtga aaaattaatg gaaaaaataa ttatagtgga agatgaagaa
    18121 gtaatcagag atgaattaaa aagcttttta gagaggtatg gatatgaagt tatggctcct
    18181 actgaatttg ataatatagt agagtttata ttaagtgaaa aacctaattt agtattactt
    18241 gatataaact tgccaatata tgatggatat tatatatgta gagtattacg taaagaatcg
    18301 aatataccaa taataattgt aacaagtaga aacactgata tggatgaact aatgagcatg
    18361 aatttaggag cagatgattt tgtgacaaag ccatataaaa cacaaatact tttagcaagg
    18421 attgttgcat tgttaaaaag aagtggatta aattcgaatg taaataatac tttaatattt
    18481 aagggtattg aattaaattt atttaatgca acactcagat ataaagataa agaaatagag
    18541 ttaactaaaa atgaatttaa aatactatct tatttagtgg agaatcaagg ttcaatagta
    18601 tctagagatt catttatgga gtatctatgg cacacaaatt ggtttgtaga cgatagaact
    18661 cttactgtca atataacaag gctacgtaaa aagctagatg aaataggcat agaaaatttg
    18721 atagagacaa gacgtggttt agggtatata atatcatgag attaagagag tatataggtg
    18781 ataaagttgt ttttctaggt actaatttaa ttatattttt aattgcatca ggtatcatgc
    18841 tttatagtaa aataaatgtc gttttaatat ttatgttatt ttgtatatgg tttttaccat
    18901 tatttactta tatgttaatt gattatttac aatataagaa gtactttaat tctatagata
    18961 atattttaga tgctttagat aaaaaatatt tgttgccaga agttattgat gatgtaaatt
    19021 ttgtaactgg agaaaaaata aatgatattt taaaagtaat aagtagaaac atgcacgaaa
    19081 atattaaata ttataatgat aatcaagaag aatataaaga atatattgaa acttgggttc
    19141 atgaaataaa aacgcctata gcatctagta aacttattat agaaaataat agtaatgaga
    19201 ttactaaaaa gatagatact caactagata aagttgaaaa ttttgtggaa caagtattat
    19261 attattcaaa aattgataat gtaaataaag attatataat aaaaaagcta aaccttgaag
    19321 aagttgtaaa tgaagttatc aaaagaaact atagagactt tataaacaaa aatataaaat
    19381 tagaacttgg tgaaattaat aagactgtat atagtgactc gaaatgggtt gagtttatat
    19441 taaatcaaat tgtggtaaat tctataaaat atataaagtc aaaagatggt ttaataaaaa
    19501 taagtgcaaa aagggtagaa aactcaatag tgttaactat agaagataat ggagtaggta
    19561 tagaagagag agatattaat aaggtatttg aaaaagggtt tacaggagag aatggaagag
    19621 tatttggaaa aagtactgga ataggattat atctatgtaa aaagttatgt aataagttag
    19681 gtttaggttt aatattagaa tcaaaagtaa atgttggtac agtcataaag gtatcattcc
    19741 ctatagatta caatttattt tagtgtatag ttataaaaac tgacaatttt tagttgtcag
    19801 ttttttgtat ttatttaaga aagttaagaa tgtaagcata attgataggt tctttttttt
    19861 acttgatttt cataaaaacg tattatatca ttaatttagt agtaaaagct gaagggaagt
    19921 aattataatg aaattagata gtaataatca ttcagtcttc ttattgcatt atcatttagt
    19981 tatgtgtata aaatatagaa gaaaagtaat agatgattct atatctgata gactaaaaga
    20041 tatatttgta gatattgcac caaattatgg ggtggtgttg atagaatgga atcattatgt
    20101 tgaccatgtt cacttattat tcaaagcaaa gcctaataca gaaatttcca agttattaaa
    20161 tgcctataaa tctgcatcaa gcagaaggat aaagaatgag tttccaagta tccgcaaata
    20221 cttatggaaa gaatactttt ggagtaaaag ttattgttta gtaacaactg gtggtgcaac
    20281 attggaagat ttggaacaat acatagaaaa tcaagaagaa tagtgataat atgttaagag
    20341 cttataagta caggtttata caaacagtga ataaaaggaa tattttccta agaattttgg
    20401 atgtaacgga cttatctatc aaagaaaatt aactatcata gctatactac taaccaaaat
    20461 agtttgtcaa cacgttactc aaaagatatt gtgcatatag aaatgggtat ataaaactgc
    20521 ttaaattaaa atcaatgatt aggataaaac aacataggca atttgataga gttgtactgt
    20581 atctaaagca tcatcaaata aatgttatat ttctattagt ttgccaacgt agtgactcag
    20641 atgctaatcg taagtgttgg gaactatcct attagcttgg agatactaat aacaatagct
    20701 attttgacaa agaagatgcc acttcaaacg ttgtcgtagg tagttaagtg tataagtagt
    20761 taattgcatg tgaaatcaaa attcactata attttattaa aaagttatac ttgttaaaga
    20821 tggtttaata taactttaat aagatatact ttaaaaggta tatcttatta aagtttttta
    20881 gccactcata aaaaataaga tattggagtg aaagagatga aatttaaatc aaatgtttta
    20941 aagcagtttt ttttaattgc tatggtaatt tttatggtag gaggtcttat agggtgtagt
    21001 aaaagtgaca aagagaataa acaagctagt actggtaaga aattagaatt aaaatatgct
    21061 agtggattta gtgttgaaga tttagaagat ggaattaaaa aagtaactga tggagataat
    21121 cgagaactga ttttaatccc aaagaagatt aaaattcctg aaaaatataa aaatgctaat
    21181 atagttagaa cgcctgtgga caatgtatta atagcatcta caacacaggc ttgttctctg
    21241 agaacaatag atgaactgga tagtataaaa gccgtaacaa cagaagagca gtactggact
    21301 attaaagaaa ttaaagattt aatgaaagat ggaaaaatac attacgttgg ttcaaattta
    21361 gcaccagatt atgaaaaaat agtagactta aatcctgact taactatagt gagtagtggt
    21421 ttatcagagg ctgatacaaa atttattgac aaattaaaag aattagggct taattatgtt
    21481 gtagacaatg agtataaaga gcaaaatcca tttggaagaa tggagtggac aagtttaata
    21541 gctgcatttt atgataaaga agatatggct actagtgaac taaataaaac tgtacaaaag
    21601 gtagaagaag taagtaaaaa aataaaaaac aaagctaaac ctaaagttgt atgggcatct
    21661 gtatatgaag gaagtgctta tatagctcct aaagattcat atgtggataa tatgataaaa
    21721 atggctggtg gaataaatgc atgtgcttca atagattcaa atgaagggcg agtaagtatt
    21781 gaacaattgc atgaagttgc aaaagatgca gatatatttg tatattcatc aagttcagat
    21841 tatgcaccaa atttagattc tataaaatct agtgcacctg tattggctga tttggatgtt
    21901 gtaaaaaacg gaaacctatg ggtgtttgct ccagattatt atcaatcagt agataagacg
    21961 gacgaattaa tagtagattt agttgagatg ttccacccag gtactacagg tgaaaaaatc
    22021 aaacattata taaattatga taaatagtac agagaggaca caaaaagata ggttttatag
    22081 attttagtta atatagcttt gctaagagga gtatacaaat ggattttatc aataaaatga
    22141 gaataaggaa tacaacaata tttatagtat taattataag tatgatactt acttttttag
    22201 tgtgtgtagc atttggctct gtaaaaattg aatttaaaga agtaatagat gttgtattaa
    22261 gaggtatgga taatacagaa cattataaaa taatatacaa tataagaatc cctagagtac
    22321 ttgcaaccat ggtaggtgga gcatgcctag cagtatcagg tattttatta cagatatttt
    22381 ttaaaaaccc aatagttgaa ccgtatatat taggagtatc ttcaggttct actttatcag
    22441 tagctctcat gattttggga ggatacacat tgggatttga gagtgtaaat tcaatgagta
    22501 tatttgtagc agcttttata ggagctttaa ttgtaatgtc tatagtcatt ttatttgcaa
    22561 ataaggtaaa gaatataaca actcttttaa taataggaat tatgaccgga tatgtatgta
    22621 gtggtataac aaatgtgtta caatcatttg caaatagtga taaattaaaa gaatttacta
    22681 tgtggtctat gggaagtttt tctggattta catgggaaaa ggtagaaata cttataatag
    22741 ttggtatatt aggtcttttg atgactgtat tcataataaa acctttaaat gcttttttat
    22801 taggagaaga gtatgcaaaa agtattggca taaatataag attttttaga gttttgatag
    22861 tatttatatc tagtatatta gcagcaatag tatcagcatt tgcaggacct atagggttta
    22921 ttggacttgc agtgccacaa atttcaaaat tgatatttaa aacatcagat aatagagttt
    22981 tgataccagt agtaatattt ttaggcagta tagttacagc tctttgtgat ttaatatcaa
    23041 gagtaatttt atcaccagta gaattaccaa taagtacgat aacatcttta ttaggagctc
    23101 caattgtagt aatgttattg gtgaaaagga aggatagggc ttagacatgt tgaaaactaa
    23161 taatttaagt gtaggataca ataacaaagt tgttataagt aatataaatg tagaagtaaa
    23221 aaatggagaa atactatgtc ttttgggaag taatggagct ggaaaaacta ccctattaag
    23281 gtccttatct aaacttatat caccaataaa aggtgaaata tatttgaatg gtgtaaacat
    23341 aaattgtata tcaagaaaag cattatcaaa aaaaatggct ttagtactta caaatagatt
    23401 attaggtgat ttaatgactg tacaagatat agtcaatata ggaaggtatc catatacagg
    23461 attttttggg agtctatcta agaaagattt aataatggta gatgaagcat tggagtctgt
    23521 agatgcctta catttaaaga aaagatattt tgatgaacta agtgatggag aaaaacaaaa
    23581 ggtgttggtt gcaagggctc ttgttcaaga accagaaata attatattag atgagcctac
    23641 aactcacttg gatataaaac atagattgga actcataaac atactgaaaa aattaagtaa
    23701 agaaaagtca atatcagtaa tactttcatt gcatgaaata gacatagcat taaaaagttg
    23761 tgataaagtt gctcttataa aaaataataa agtcatagct tatggtcagc ctgaagatgt
    23821 agtagatgag gatattataa attcgcttta tgaattggat gataaaaact ttaatagtct
    23881 tttaggttca gtagaaatta gtaataaatc taaaaatgaa gtttttataa ttggtggtgg
    23941 gggtaaagca acaccaattt atagagcttt tactaaaaaa ggtataggtc tgtattctgg
    24001 aataatacat gaaaatgata ttgattatga aattggtaga actatgggga taaagatgtt
    24061 tacagaaaat ccatttgagc ctataagtga tgagagtttc gatttggcta ttagaaattt
    24121 aaatgattcc aagattataa tagatacagg atttagtgta ggagagacaa ataagaggaa
    24181 tatagatatt ataaaagagg ctttaaaatt ggataaaaaa gtttattctt ttagaaatag
    24241 agatgagagt aagaagtatt atgacagttt ggataataag atagaacata tagataaagt
    24301 ttctcaaata atcaatagtg cagatataaa taatttatta taatttatga aataaaatgt
    24361 acttatgtgc tatagaaaaa agagtataga ttataatttt tttgaaatta taatctatac
    24421 tcttttgtta ttttgtttat gtatttatat atttataaaa ctttagcatt ttatagataa
    24481 ccaatagctt cctctctagt taaaaaaaag tgaatccctg tagtcgattc tttccatcta
    24541 ttttcattaa aatcttcagc tacaatcgtt tctcctactc tatatataaa attttcatca
    24601 gcatatgcac gagcactttt aaaagattct ttaccatcta tactagtaat tgacagtact
    24661 tttgccttat cacatctaca agcatttgat gtagcagaca ctctttttgc gtcgctgggt
    24721 attaataatt gtaccattct aaaattaaaa cattttttat agcctataaa tgctcctgtt
    24781 tcaggacaat acaatttaaa aaaacgggta ctttcatctg atattactcc atttaaagta
    24841 gcatgttcta aatttgaatt ttctaaatta gctcctctaa tatctgagtt agataagtca
    24901 caaaatctaa aacttgcacc acttaagtct gcatttttta atatagaatt ttttaatgaa
    24961 caatccgaaa gataagaatt attaaaaata gagttttcta aatctgcttt ttctaaattt
    25021 aaattgataa ggtcagacca cgaaaagtca atattactta agcagtatcc tcttaagtcc
    25081 atattttcta atcttaattc ttttaaatct gccttttctc cagcattatt gtttttaagc
    25141 cataaataat gtttctcaag tgttttttct aattcttgtt tagaaatagt tttcattaaa
    25201 atcaccttca taaatttatt tttatatatg tagtagcaaa atagtcatat atttaattat
    25261 ataacaataa ataaaaaact tctaaataat atataaaata tcatcttgaa agtacttttt
    25321 tcaatatatc agaatatatt tttaagctat ttagagataa tttaaatttt taaacaggac
    25381 ataataagct tgtattgttt tatatttgag ttgataaaaa tttctttaaa taaaaataat
    25441 gtcaattata aagtaataaa agtttagata taaaaaaatt tgtgtatata ctatatgtag
    25501 tatataatag ataaagcact gactatatgt agtgcttttg tttttgaaaa atacttattg
    25561 catttctata attatagatt aattttggga tttcaactga taagtaccaa aagaaataat
    25621 aagcaaatta agtgaaatta tggcacaaga ttatgttaaa aggacggtaa ataatgaatt
    25681 ggatagagct taacaatcaa gtgataatta aaaatgaaca aggcaagtac caattggaaa
    25741 aggataagga agccttaagt agttacatag aagaatttat acagccaaag ttgaaaaaat
    25801 ttaataacct agaagaaaga ttgaagtatt taatagatga aggttattat tcaaaagaag
    25861 taataaatca gtatagcata gatgttatca aaaatatata tgatatgatt gataaacata
    25921 agtttgaatt tcaatcatat atgagtgcaa ataagtttta tcaaaattat gcattaaaga
    25981 gcaatgatgg aaaggaaata ttagaaacat ataatgataa agtgttaatt gtagctttga
    26041 cactaggaaa tggcaataaa gatttagctt taaacttggc agataaaata gtaaaacaag
    26101 aatttcaacc agctacacct acttttttaa atgctggaag aaaaagggct ggagaaatgg
    26161 tatcatgttt tttactatct gtagaagata gtacagaagg tatatcgtat gctatatctt
    26221 catcaaatca cttatcaaag attggtggag gagttgcact aaatttatct aaacttagag
    26281 catctggcga atctatcaaa gatatagaag gtgcagctgg aggtgttgtt ggagtagcta
    26341 aaatgttaga acaatcattt agttacttta atcaaatggg agctagacaa ggttctggtg
    26401 cggtgtacct tactgtattc catcctgatt ttgaattgtt gatggatact aaaaagataa
    26461 atgcagatga aaaaataagg cttgctacat tatcattagg agctataata ccagataaat
    26521 ttatggagtt ggcagaaaaa aatgaagtag catatgcatt ttatcctcat actgtgtata
    26581 agaaatatgg agtttctctt gatgagatag aaatggatga gtggtatgat aaattggtta
    26641 atgatagtga tataagaaaa aaagaaataa atcctaggca gatgttgaca aaaatagcac
    26701 agatgcaaca agaaagtgga tatccatatg tagtgtacat agatacagct aatagagaac
    26761 atacattaaa agatgttgga attattaaaa tgtctaactt atgttgtgag atatttcaat
    26821 atcaaacacc ttcagaaata gaggggtatg gaggaaaaaa tgaatgggga caagatataa
    26881 gttgtaacct aggttcttta aacatagcca atgtaatgga taataaaact atagaaagta
    26941 cagttgaaac agcaataaga gcactgtcat ttgtagcaga tagcacagat ataaaaccag
    27001 taccaacggt aagcaatagt aacagcaagt ctcattctat aggattagga gctatgaatt
    27061 tacatggata cttagtaaga gaaaatattt tatatacttc agatgatgct atagattttt
    27121 ctaatgtatt ttttgcaatg gttagatact attcaattaa agcttctatg aaaatagcta
    27181 tagaaagaaa tcaaactttt gaaggatttg ataaatcaga atatgttaag ggaagaaata
    27241 gcaaggtttt atcaaaatac tatgaacaat cttatctacc taagtcagaa aaggtaagag
    27301 cattatttga agggatttat ataccaacaa aagaagactg gacaaaatta ttggatgagg
    27361 taaaagaaaa agggatatat aatgcatatt taatggcagt agcaccaact caaagcatta
    27421 gttatgttca aaatgctaca tcaagtataa tgccaattac tgagccagta gaagtaagaa
    27481 catatggaga ctctactaca atatatccaa tgccattttt aacaaatgat aatatgttgt
    27541 attatcaatc agcatacagg atggatatga gaaaggtcat agatttagtg gcaacagttc
    27601 aaaaccatgt tgaccaaggt atatcaacaa cactgtttgt tacagatgaa aagacaacta
    27661 gagatatagc tagacattac atatatgcat ataaaaaagg tttgaaaagt ttatattaca
    27721 caagaacaaa gatgacaaga gatactcatg agtgtctagt gtgttcagta tagggagaga
    27781 aatatatgac atttaattta cataaaatac ataatgcagt taactggaat agagaagaag
    27841 atggatttac acaagctttt tgggaacaaa atgtaaaaca attttggctt cctgaagaaa
    27901 tatctgtttc taaagacata aaggtatgga atgaactaag taataaagaa aaggaattat
    27961 ataaaaaagt attgggtggt ttaacattac tggatacaaa acaggggaat aatggaatac
    28021 catctatgat gagtttaaca gaaaacctac aaagaaaagc tgtcttgtct tttatgggga
    28081 ctatggaaga aatacatgca aaaagttatt cttctatatt tatgactcta ctttctaatt
    28141 tagaaataga tgaattattt gaatggatag aaacagaacc aacattacaa agaaaggctg
    28201 atttagtttt agctcaatac gaaaatacta caaatcaaga gggattatac ctatcaatgg
    28261 ttacaagtgt atttttagag agtttcttgt tttattcagg attcttttat ccattgtatc
    28321 tatctggtca aggaaagatg gtagctagtg gagaaataat atcgcttatt cttagagatg
    28381 agtctttaca tggtaagtat ataggattgc tagcacaaga aatatacgat tcatttgata
    28441 aaatggataa ggagatgtta gaagagaaga tgtattctat actttatagc cttatggaga
    28501 atgagataga gtatacaaat gttatataca gagaaagtgg gcttgaaaaa gaggttgtaa
    28561 actttttaaa atacaatgcg aatagagctt tagaaaatct agggtttgag aagctatata
    28621 ctgtagatgc tataaatcca attgtattaa atggtcttag cactgaaacc aaaacacatg
    28681 atttcttttc aactaagggt aatggatacc aaaaaggagt gtatgaggaa ttagaggatg
    28741 aagattttat aatataattt ataattatga cacactgttg tcacttttag cgtgataata
    28801 tcaatgtata aaatatatat ggaggtattt ttatgaaata tgaatggaga aaaagagata
    28861 aagagttata tttacctaaa aagaatcctg taatagttga aataccagaa cagaaattta
    28921 tcatgttaaa agggagtgga gacccaaatt ctaaagaatt tactgaagca ataggagtac
    28981 tttattcttt ggcatatgca ataaaaacca tgcctaaaaa aggaattgta ccagaagggt
    29041 attttgacta tacggttttt cctttagaag gtatatggga taagggagaa aaaagtaaag
    29101 gcttagatgt acttattaaa gaagatttaa tttacactat aatgatacgt cagccagatt
    29161 ttgttacaca agacctgttg gataaagcta ctgatatagt aaagaagaaa aaacctcata
    29221 atcttcttga aaaagttaga tttgggtcta ttaatgaagg gctatgtgtt caaaagcttc
    29281 atataggttc atatgataat gaaccagaaa gctttgacat tatgaacgaa ttttgcaaag
    29341 aaaataaact tataagaaaa tcttacacac atcgtgaaat ttatataagt gatgctagaa
    29401 aagtatcgcc tgaatcattg aagacggttt tacgttttga agtagaaagg gaagtataaa
    29461 tattttgaat aatttataag agttataaaa agtgaagtct gttgagactt cattttttga
    29521 tgcaatttta aaattaaatt tgatgtttca taatatttta aaaactttct acttttatta
    29581 gtgtgaataa ctgttgctat taaataataa ta
//
LOCUS       DAEQCW010000042        27739 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.042, whole genome shotgun sequence.
ACCESSION   DAEQCW010000042 DAEQCW010000000
VERSION     DAEQCW010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27739)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27739)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27739
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.042"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            583..1578
                     /locus_tag="KRO40_001870"
     CDS             583..1578
                     /locus_tag="KRO40_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2092690.1"
                     /translation="MSIIELNELTKSYRRFEKKAGFMGSVKSLFNRKYTEKTAISSFD
                     LKIEEGEFVGLIGQNGAGKTTLIKMLTGIIAPSSGEISVMGYYPNKLENNFKKQYAVV
                     MGQKSQLFFELTPADTFLLFKELYDISNEEYKKNLDYFIELFEVSDYLNVQVRTLSLG
                     ERMKMELIVALLHNPKILFLDEPTIGLDAIAQKQIRYFLKEVNETKGTTIILTSHYME
                     DIKSLCSRSIVVENSRKIYDGSTEKLFNYFQKYKKITVSFSNETNIVFPKDCKVVEQT
                     NHKTSVIVPKERGNETIKWIFDKYDVKDVMIEEEDIGSIVERIYKKGSDEYYEQL"
     gene            1556..2419
                     /locus_tag="KRO40_001871"
     CDS             1556..2419
                     /locus_tag="KRO40_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBH2092691.1"
                     /translation="MSIMSNYNEASSNYSMFYKFKQSIRRYYEVAKINFKVQLIWRFD
                     VVVNMVFTIVKILFAYILWKAIFGENKIVSGFTFNSMLSYYIISSFLAGIDMSKSTSE
                     EICNRVKLGTFSKYMIIPINVQNYFIAKNFGMTCFYFVFNMISAFVWIFIFKIDFAFT
                     SNPVQILISILMIFLGFIFMMKLHFFIGILSFKFLEISFFRMIIENIVEFITGTMIPL
                     VLLPETIVTVMKVFPFYYTTYLPSMLLIGRNSNEAIQGLIILALWVLFFSVVNKVMYK
                     RMRTLFDGVGI"
     gene            2416..3210
                     /locus_tag="KRO40_001872"
     CDS             2416..3210
                     /locus_tag="KRO40_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBH2092692.1"
                     /translation="MMKKNLKIIFMLLKMKLSKMMVFRFDFFGAFFVDSSLFILQLLM
                     FNSIYSHVDSIGGWKQGEMLIFIGTFSLINAINMTIFFFGIYDIPRKIQEGELDYYIT
                     KPLDPLFRLTFENINIGSSPLILASILIVLYGISELNSEITLAMIIIYIFMVLLMTLL
                     FYDVCIILRTVSFFVISSSAIMRLEDNLLPMNMKIPGVIYEGVFKVLFYLILPYGIMS
                     TIPTQILAGTITINGLIYSILIVFLFTLFMWRFWKLGMRHYKSASS"
     gene            3495..4874
                     /locus_tag="KRO40_001873"
     CDS             3495..4874
                     /locus_tag="KRO40_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2092693.1"
                     /translation="MSDVYYSENHEQDNLYEQDNLLAQRFNLFTLLKFAFPTIFMMIF
                     MGLYTIVDTIFVSRFINTNALSAINIVCPIINLIVGIGTMLATGGSAIVARKMGNGDI
                     EGANKAFSLIVLSGVVIGVIITGIGIVFMDYIIIWLGASEVLIKYCRSYLFIILVFAS
                     ANILQVLFQCLFVTAGKPQFGLWLVLGAGCANIILDYVFIVLLQMGISGAALATGVGY
                     LIPTVSGMVFFSKNKGLLKFCIPRLDKRILFEACFNGSSEMVSQLSTAVTTFLFNAMM
                     MKLIGEDGVAAITIIIYSQFLLTSLYIGFSMGVAPIISYNYGSENNTQLNHVFKICIL
                     FISVASLLVFIFSISCSPIIVEIFSQRGSRVYEIARSGFYIFSFSFIFCGYNIFTSSM
                     FTALSNGKVSAILSFLRTFGFITIGLLILPNILNINGIWLAVPSAEILTLFLTIFCIC
                     KYKNRYKYM"
     gene            5322..6035
                     /locus_tag="KRO40_001874"
     CDS             5322..6035
                     /locus_tag="KRO40_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092694.1"
                     /translation="MDTCFNKKILLVDDEKDIVDLIEEVLINDGFKNIIKAYNGLDAI
                     SLCKIACPDVVILDIMLPDIDGIEVCKKIREFSYCSILFLSSKNDDIDKILGLSSGGD
                     DYITKPFSPREIAFRVKAQLRRQQYQSIVPSDSEVIKIGDITIDIEGNRVYKDRNEIE
                     LTGREYHLLSYMAQNVNKIIGKERLYEQVWGVYSSICDNTIMVHIRHIREKIEDNPSN
                     PKILITVKGLGYKLVNRID"
     gene            complement(6307..7845)
                     /locus_tag="KRO40_001875"
     CDS             complement(6307..7845)
                     /locus_tag="KRO40_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH2092695.1"
                     /translation="MSLLKVTNLSQCFMDKSLYEKANFDLFKGEHIGVVGQNGTGKST
                     LIKILLGEVVPDSGEIKWQPNINIGHLDQYAEINRDTTISLYLHTAFEELYKIEKEMN
                     LLYQKSAISENEQYLIKASDYQEQLIASNFYSIDNEINKIANGLGLDSIGMNRVVREL
                     SGGQRAKVILAKLLLSNHDVLLLDEPTNFLDKEHVEWLSNYLNTFNGAFIVVSHDFDF
                     LEKISTGILDIEFGMIKKYHGKYSEFLKQKSHLREDYIRRYQAQQKKIEKEETFIRKN
                     KAGVNSKIARGRQKQLDKIERIAPPSFTGKPNIQFSEIEISAQNALTITNLEVGYYYS
                     LLPKLNFSVDGGQKIVITGFNGIGKSTLLKTLVKDIPRISGDFQFSEQVKIGYYEQDL
                     KWENPDKTPLQIVADKYPKLNTKEIRRHLARCGVKEEHVSRSVSTLSGGEQSKVKLCC
                     MMLSPCNFLILDEPTNHFDAETKDALQNALKQFRGSIILVSHEEKFYKGWIDKVFNIE
                     KQLV"
     gene            8727..9182
                     /locus_tag="KRO40_001876"
     CDS             8727..9182
                     /locus_tag="KRO40_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBH2092696.1"
                     /translation="MDEIDLKIINSLKKNSRASTSEISRQINLSVPAVSERIRKIEQS
                     NLIQKYTIQINREKTKYKLLAFIFINTDLSKSMKEFKKTILEYDTVLECHHISGEYDY
                     LIKVLAEDTSNLEEFISVTLKEIGGIQKANTTIVLSTIKEEFNTIKDIF"
     gene            9231..9815
                     /locus_tag="KRO40_001877"
     CDS             9231..9815
                     /locus_tag="KRO40_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HBH2092697.1"
                     /translation="MKVLVFLAKGFETMEFSVFVDVMGWARNDYGHDIDVVTCGFKKQ
                     VMSTFNIQVLVDKTIEEVCVDDYDALAIPGGFEEFGFYDEAYDSSFLNLIREFNSKEK
                     IIASICVAALPVGKSGVLKNRKATTYHLKNGKRQRQLSEFDVNVVNEPIVVDKNIITS
                     YCPETAPHVAFKLLEMLTSKEQMDEVKLAMGFKL"
     gene            complement(9820..10143)
                     /locus_tag="KRO40_001878"
     CDS             complement(9820..10143)
                     /locus_tag="KRO40_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092698.1"
                     /translation="MKKCLDNYSCPIEATLALIGGKYKTLILWHLKDTILRFNELKKL
                     IPKATPKMLTQQLRELESDGLIIRVVYPVVPPKVEYSLSDFGKSIIPILDSMCDWGSD
                     YLENL"
     gene            10295..10813
                     /locus_tag="KRO40_001879"
     CDS             10295..10813
                     /locus_tag="KRO40_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2092699.1"
                     /translation="MNFVELAKKRYSCRNYQDRKVEKEKLEKVLDVARIAPTGGNRQP
                     QRLIVIQEKEGINKLSKAANIYDAPLAILVCGDKDKVWTRPFDGKQLTDIDTSIVTDH
                     MMLQATELGLASVWVCYFNPDIIREEFSLPDNLEPINILLMGYESKIPESPERHEKTR
                     VPLSEIVSYETL"
     gene            complement(10989..11657)
                     /locus_tag="KRO40_001880"
     CDS             complement(10989..11657)
                     /locus_tag="KRO40_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-binding protein"
                     /protein_id="HBH2092700.1"
                     /translation="MLEVSHKVKEIYPNIKFGVMVINITHSKPNKENFLVLKNSTIKN
                     IIEQHPEYNRKEKIKTEPVSSYIKYYKKFKKTYPVLLQLESILLKSKGIPDVGVTIES
                     MFLAELKNLLLTAGHDLDKMELPLKIELANGSEHFYGIGGKEHILTKDDLFLSDNIGI
                     LSSILNGPDNRTAITKDTKNIMYFVYGPDKISEKQIQDHLNDIKHYISSAFPDLKVNS
                     IDIF"
     gene            11772..13187
                     /locus_tag="KRO40_001881"
     CDS             11772..13187
                     /locus_tag="KRO40_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2092701.1"
                     /translation="MWITINRNSNISLSRQIYCEIKDMILDGSLKFEQKLPSSRTLSK
                     ELSVSRNTVLDAYNQLIAEGYLETRNGYGTIVAKGISGHKVDFKLNDTFRDEKDLHTN
                     KQKNYIDFRSGVPELKLFPRKELSKLYKQILYDLSDSDFRYGSTAGVWVLRVEISKYL
                     FRTRGIRCNPKNIMIVSGSTQGLSLISQLLYKSNKKVAVEDPIHKGLLKVISSIGYSV
                     VGIKVDDKGMNTNLIKSIKGISFVYTTPSHQYPLGGILPIQRRLELIKCATENDYYII
                     EDDYDSEFRYEGQPISSLYELSPNKVIYIGSFSKILSPAIRVGFMLLPDNILESYKTL
                     KMYSDVHTETILQHVLAEFIGNGGLEKYIFRMKKLYNRKRKYLIKVLNTEFKNEFKIK
                     GEAAGLHIVAHFYNVKFTESLIHKIFEAGIKVYPIQQYAIENILEYDYEIILGYAHLS
                     FDEIEKGVKILSKIIHMNQGT"
     gene            13410..13868
                     /locus_tag="KRO40_001882"
     CDS             13410..13868
                     /locus_tag="KRO40_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092702.1"
                     /translation="MEIIDYIEENLTENLNLDKIAYIANYSKYHLHRMFTNVVGCTIH
                     QYIQRRRLTEAARQLIFTDKYIIDIAITVGYSTHQSFTLAFRNLYKESPQVYRNKDEF
                     YPIQQRFVLNLNHQIQSEKCISYANMNYKQRRDEINSYLNFNINCEVKVA"
     gene            13865..14449
                     /gene="clpP"
                     /locus_tag="KRO40_001883"
     CDS             13865..14449
                     /gene="clpP"
                     /locus_tag="KRO40_001883"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBH2092703.1"
                     /translation="MSLVPHVIEQTGQGERSYDIYSKLLKDRIIFIGEEINDAIASLV
                     VAQLLFLESEDPDSDIIIYINSPGGSATSGFAIYDTMNYVRCDVSTICIGMAASMSAF
                     LLAGGTHGKRCALPNSEIMIHQPMGGAKGQATDVKIAVDNILKIKERLDKILSENTGK
                     SIEDIRRDTDRDNFMTALEAKEYGLIDYIMNRNE"
     gene            14761..15837
                     /locus_tag="KRO40_001884"
     CDS             14761..15837
                     /locus_tag="KRO40_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092704.1"
                     /translation="MITISLCMIVKNEEEVIGRCLECVKDIVDEIIIVDTGSTDSTKE
                     IVSKYTDMVYDFEWIDDFSAARNFSFSKASKDYTMWLDADDIILEADREKLLKIKESL
                     DTSIDIVMAKYNVSFDENGNPTLSYYRERLFKRSSNHKWVDPIHEVVPLFGEVFYSDI
                     AISHKKLHRQDPLRNLRIFEKMISEGKTLEPRHQFYYSRELYYNARYKEAIEGFTKFL
                     DSSRGWIEDCISACRDLATCYYLINDEKSALYSLFRSFEFDEPRAEICCDIGKHMFDR
                     QKYKEAIFWYKVALTRDKNDTNGGFKSNDCYGYIPSIQLSVCYDRLGESDKAIYYHEK
                     TKEIKPNDSAVLHNENYFSKFKNS"
     gene            15904..17970
                     /gene="bclA3"
                     /locus_tag="KRO40_001885"
     CDS             15904..17970
                     /gene="bclA3"
                     /locus_tag="KRO40_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA3"
                     /protein_id="HBH2092705.1"
                     /translation="MLLIMSRNKYFGPFDDNDYNNGYDKYDDCNNGRDDYNSCDCHHC
                     CPPSCVGPTGPMGPRGRTGPTGPTGPTGPGVGATGPTGPTGPTGPTGNTGNTGATGLR
                     GPTGATGATGPTGAIGFGVTGPTGPTGATGATGADGVTGPTGPTGATGADGITGPTGA
                     TGATGFGVTGPTGPTGATGVGVTGATGLIGPTGATGTPGATGPTGAVGATGIGITGPT
                     GPTGATGADGATGVTGPTGATGADGVTGPTGATGATGFGVTGPTGPTGATGIGITGAT
                     GLIGPTGATGATGATGPTGVTGATGAAGLIGPTGATGATGADGATGATGATGATGPTG
                     ADGLVGPTGATGATGADGLVGPTGPTGATGVGITGATGATGATGPTGADGLVGPTGAT
                     GATGADGVAGPTGATGATGNTGADGATGPTGATGPTGADGLVGPTGATGATGLAGATG
                     ATGPIGATGPTGADGATGATGATGPTGPTGADGLVGPTGATGATGATGATGPTGATGA
                     TGATGPTGASAIIPFASGIPLSLTTIAGGLVGTPGFVGFGSSAPGLSIVGGVIDLTNA
                     AGTLTNFAFSMPRAGTITSISAYFSTTAALSLVGSTVTITATLYQSTAPNNSFTAVPG
                     ATVTLAPPLTGILSVGSISSGIVTGLNIAATAETRFLLVFTATASGLSLVNTVAGYAS
                     AGIAIN"
     gene            18139..18900
                     /locus_tag="KRO40_001886"
     CDS             18139..18900
                     /locus_tag="KRO40_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBH2092706.1"
                     /translation="MKNKIEISMNNFVKNYHKSNNITTKWQELLFAYASAEDDMFQKL
                     KSVVGTSHAMPKDFLENGKTIITYFIPFDESVNNSNIGGFECSEIWARAYIETNMLIS
                     NLNDFLCEELEKMGANSYAIPGSYNFDSEKLVSDWSQRHVAFIAGLGTFGLNNMLITE
                     KGCCGRIGSIITSLELEPTKRPENEYCLYKHNNSCKKCVNKCVKEALKEDGFNRNKCY
                     EMCMINEKKYTYIGGCDICGKCIVGVPCSVINPSR"
     gene            19209..19487
                     /locus_tag="KRO40_001887"
     CDS             19209..19487
                     /locus_tag="KRO40_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092707.1"
                     /translation="MSYKKAIHILPEELLELIQEYVDGECIYIPRKSNNKKEWGSNTP
                     TREELSIRNMQIYEDYQVGYDLQYLSEKYYLSLKSIQRIVLQEKRKDI"
     gene            19780..20355
                     /locus_tag="KRO40_001888"
     CDS             19780..20355
                     /locus_tag="KRO40_001888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1062 domain-containing protein"
                     /protein_id="HBH2092708.1"
                     /translation="MKKITWEVEYISQLPVIRYCKKCGKKTEYICSGLFRVNAQHKYL
                     DIWLIYKCSNCDSTWNSTIYSRVNPNRLSTETLEQFHTNDDNLANQYAMNVELLHRNG
                     AEVGIPEYKIVGQEIDINDLTQVRIVSKYPSQLKVSALLREKLGLSRKAFDEMLDCGT
                     IKSISGVDLRRSKLNYEIVLEVGKQKQKSSN"
     gene            20794..21504
                     /locus_tag="KRO40_001889"
     CDS             20794..21504
                     /locus_tag="KRO40_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092709.1"
                     /translation="MINIGICDDELHYRIKIKDILSEILSSYPINYNIYEFSAGEELL
                     NNYPKDLDILIMDIQMKTINGMDTARKIREFDHKLEIIFVTSFVEFMQEGYEVKAYRY
                     ILKPINKEKISKSVLPCINEMMKKRNNYLTINVKNYVDRIKIDSITYIETDRPNILIY
                     THDDMYITKMSISKIEKILNEYGFFRCHNSYIVNLKLVESMSGSTVIVDGKSIPISKY
                     RVKGLKLAITNILGDIVC"
     gene            21498..22814
                     /locus_tag="KRO40_001890"
     CDS             21498..22814
                     /locus_tag="KRO40_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2092710.1"
                     /translation="MLTNLSVGFWNIINLVSGTIDWIIFFLVIHLVGKRKISNIRYIF
                     TTIIIIIFMAYINVVKVFPNIKILLCMVIGISFYITSYEDKIYKSIIVSLLFWLGLMV
                     AEGSAVGLVVFINKLNNINITQHENLFRIQAIIMSKVFLFIGFILFKYFKLSLDFKPK
                     DMILIGIPILSNIVSLLLIFEYNLRVNTITTENLFIFIFAILLILSSSIILLIVIGKI
                     VQDDKLNLEYELINERIKTNYRNYENINEVHDRLKYVYHDLKNHMICIKNYDTKEEII
                     SYINNLEFQISEFEHFKNTGNKTLDLILAEKISICKKYDIQIEDNINISKLNFIKNND
                     ICSIFANSLDNAIEACMDINNEIEKRIEVKATYINKFAIIKFINTKVNDIKLIDKRIQ
                     TSKDDDNIHGIGLASIKYIVNKYGGETIVNYSDNEFILKIMIPIKS"
     gene            22826..22966
                     /locus_tag="KRO40_001891"
     CDS             22826..22966
                     /locus_tag="KRO40_001891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="HBH2092711.1"
                     /translation="MKKIALNLLKNISALSFGIAVLSANSASSWVAHQAKEPQALQKL
                     KK"
     gene            23025..23606
                     /locus_tag="KRO40_001892"
     CDS             23025..23606
                     /locus_tag="KRO40_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory gene regulator B family protein"
                     /protein_id="HBH2092712.1"
                     /translation="MFKRLSYKFANILVNNEIVESEDFEIYRYGFETLIYFIVNILVA
                     LFIGIIFDRFIHTVIFLSCYCTLRQFTGGYHARNYKECTLTFVVIYLITIFSANNIDI
                     NKYKYLLVLLMIISILTIYKLAPLEHRNKPLSESEKKHYRKTVQKILFVIICLIILCK
                     ILNIFQQYVIYAIISIYWIAILIYIGMKVNSDQ"
     gene            23863..24237
                     /locus_tag="KRO40_001893"
     CDS             23863..24237
                     /locus_tag="KRO40_001893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092713.1"
                     /translation="MNLKKKIKKLGVTFAIGTIIVSSLGTSVFADEVSTYALISKAFS
                     GKNNIISSSVYTSGSRTFKTTDSQGGFSCRLTERFSGSSPDRIVKRHEANASSKVSLS
                     GGTYYIRYEGSTNNAKTYATLN"
     gene            24320..26029
                     /locus_tag="KRO40_001894"
     CDS             24320..26029
                     /locus_tag="KRO40_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092714.1"
                     /translation="MSSIKVISDFITKIIRKNILFAITIIIINYHLIQRWTHISNRGI
                     SFNDYLSLSVYTCMTISILTMLNVIFYMRKSYDTVKILCRNNFDYFLGISVAVTRNNF
                     IFCCIPIIYAIAYSSLIRTLSIVTIKSTIFILIFEWFLPLTILSIVISFISVIINNLI
                     LKITLSSVFLYLTSTNMLDRVIDIKEPFFKALFKSLNIFEDQSYAYYSDFVGKVNNSA
                     YVIDKIIPTLFAITLIIVAYLILNDIRKKQIKSLIVIVVYSILFIGLNYISIDMSTYR
                     DEERSYGEYLKKSNISDIKIKSHDMKIDFKSKSNIKDRIVLLNTSNEELTNINMILDE
                     IFDIKYIKINSENIKFNKKKDLIEVNLKESLEPNDEVTLDIEYEGYINVLTSWNQNKY
                     IATKDDIMLPPGSLAWYPKVNQSSCMAYKINLSSKNNVYSNLPLLNKTSNFLKKDYIF
                     EGKSNDIAIYAGEFKEEVKDDIKIIYPSDSNVNMDIEEKIKFLIETRNEILGDSKASV
                     DAKKYVDEVDNVMESIKRKKINMILVADLPSNEFLYEDSKGEKISITIYHWLSGNILI
                     IDK"
     gene            26044..26916
                     /locus_tag="KRO40_001895"
     CDS             26044..26916
                     /locus_tag="KRO40_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2092715.1"
                     /translation="MINKLEIRNLNFNYKNKKALDNINLTLTDGVVALLGPNGAGKST
                     LMRLLVTLYETSIGEIELNNIKYSKNNEKIKANVGYVPQDFDMYNNINGQEYLEFVAK
                     MRGVSKNDLKKHIQKVVSKVNLDKFINKKIGTYSGGVKRRLGIAQALIGDSKLIVMDE
                     PTVGLDPEQRNEFRRLLPEISKNSIVLISTHIVEDIQFNCDKLIILNQGKILYDGTIN
                     KFIDMVEVYSVVVSNDEFEYLERNIDIIDYRRVKDGVQVKYIGKNTEKLKDSLRIDTT
                     LQDAYINFLHKELK"
     gene            26917..27705
                     /locus_tag="KRO40_001896"
     CDS             26917..27705
                     /locus_tag="KRO40_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092716.1"
                     /translation="MCILELIKFELKKIELKHVLIFVIISILCIFITGILDYNELIFY
                     NDVPIMDTYSIAGWLGIIKISDVFIPIMSAITIIYVFSKDYSGNINEILTLYNKKKYN
                     QFIVFRWCVILAIYTVLLLISITIVYTFTSVKGFNIDKIDFVYSVKPIDVFLKTFPTL
                     LWYTTFPLMILTLTKNRFTTIAILITYTFADIFFILHMYPFVSMINVNGFYIQKMFYM
                     PNNIDVRFNELKNYFFINRGSLVVISIIIVFYIARKSTVLKKSK"
BASE COUNT        10608 a         3100 c         4573 g         9458 t
ORIGIN      
        1 ttacaataaa aatattacag taaaatgacc agttttaata tacgtattat atttttaatt
       61 tataaacgaa tattataaat gaaatttaaa ttcaaccttg aagaaataag ctaaatgtat
      121 tagtatataa atccatgctt gaacataaat aacctttatg atatgatatc aataataata
      181 ttatgagagg agtgccttga tgtcggagtt atataatggt aaccaacaat taaatagttg
      241 gagacacata tattctgtat aatcagaaat ttcaagtgta tttttaatac atttaatttt
      301 tgtgtcttat tctgccttta tagataactg acatatgaca acaaatagta tttaaaatat
      361 atattacttt gttaaattat ggtgtagtag gctttaatct gctacacttt tattaatttt
      421 gtatagtatt attttgataa ttattttgaa atagagagca ttaatttttc tagtccacag
      481 gagttttctg tttttgtgct gttaaatata agcacagaaa aaggcagata tatacctgtg
      541 gacttttttt tatataaatt atgaaatatg gaggtagtta aaatgagtat aattgaactt
      601 aatgaactga ctaaatctta tagaagattt gagaaaaagg caggatttat ggggagtgta
      661 aagtctttat ttaataggaa atatacagaa aaaacagcta tatcgtcatt tgatttaaag
      721 atagaagaag gagaatttgt tggattaata ggtcaaaatg gagctggcaa aactactctt
      781 attaagatgt taactggtat tattgcaccg tcttctggag aaatatctgt aatgggttat
      841 taccctaaca aattagaaaa taattttaaa aaacaatatg ctgttgttat gggccaaaaa
      901 agtcaactat tctttgaatt gacaccagca gatacgtttc ttttatttaa agaattatat
      961 gatatatcta atgaagaata taaaaaaaac ttggattact ttatcgaatt atttgaggta
     1021 tctgactatt taaatgttca agttaggacg ctttctttag gagaaagaat gaaaatggaa
     1081 ctaatagtag cccttctaca taatccaaaa atattatttt tggatgaacc aactataggc
     1141 ttagatgcta tagcccaaaa acaaattagg tatttcctaa aagaagtaaa tgaaacaaaa
     1201 ggaactacta ttatacttac ttctcattac atggaagata ttaagagtct ctgtagtaga
     1261 agtattgttg tagaaaatag tcgtaaaata tatgatggtt ctacagagaa attatttaat
     1321 tattttcaaa aatataaaaa aataacagtt agtttttcca atgaaactaa cattgtattt
     1381 ccaaaagatt gtaaagttgt tgaacaaaca aatcataaga catcagtaat tgtgccaaaa
     1441 gaaagaggaa atgaaacgat taaatggatt tttgataaat atgatgttaa agatgtaatg
     1501 attgaagaag aagatatagg tagtattgta gagagaatat ataagaaagg aagtgatgag
     1561 tattatgagc aactataatg aagcaagttc aaattattca atgttttata aatttaaaca
     1621 gagtattaga aggtattatg aagtagccaa aattaatttt aaagtgcaac ttatctggag
     1681 atttgatgtg gtggttaata tggtgtttac gattgtaaaa attttatttg cttatatttt
     1741 atggaaagca atttttggtg aaaataaaat agtctctggt tttacattta actctatgtt
     1801 atcttactat ataataagct catttttagc aggtattgat atgtcaaaga gtaccagtga
     1861 agagatatgt aatcgtgtaa aattgggcac cttttcaaag tacatgatta ttccaattaa
     1921 tgttcaaaat tattttattg ctaaaaattt tggaatgaca tgtttttatt ttgtatttaa
     1981 tatgatttct gcatttgtat ggatttttat atttaaaata gattttgcct ttacatcaaa
     2041 tccagttcaa atattaattt caattttgat gatttttcta gggtttattt ttatgatgaa
     2101 actccacttc tttattggga ttttgtcatt taaatttctt gagattagtt tttttagaat
     2161 gataattgaa aatattgttg aatttattac aggaacaatg ataccacttg tactcttacc
     2221 agaaactata gtaacagtta tgaaggtatt tccattttat tatacaacat atttgccatc
     2281 tatgttacta ataggtagaa acagcaatga ggcaatacaa ggattaatta ttctagcatt
     2341 atgggtttta tttttttctg tagtaaataa agttatgtat aaaagaatga gaacattatt
     2401 tgatggggtg ggtatatgat gaaaaaaaat ttgaaaataa tatttatgtt attaaaaatg
     2461 aaattatcaa agatgatggt atttagattt gatttttttg gagcattttt tgtagatagt
     2521 tcattattta tattacaact tctaatgttt aatagtatat attctcatgt agactcaata
     2581 gggggatgga aacaaggaga gatgttaata tttataggaa ctttctcatt aataaatgcg
     2641 ataaatatga cgattttctt ttttggtatt tatgatattc cacgaaaaat ccaggaagga
     2701 gaattagact actatattac aaaaccatta gatccactat ttaggttaac atttgaaaat
     2761 attaatattg gttcatcacc attaattcta gcaagtatac ttattgtttt atatggaata
     2821 tctgagttaa actcagagat aactttagct atgataataa tatatatttt catggtgtta
     2881 ttgatgacat tactttttta tgatgtatgt atcatactta gaacagtttc attttttgtt
     2941 atatcatctt ctgcgataat gagattagaa gataatttat tgccaatgaa tatgaaaatt
     3001 cctggtgtaa tatatgaagg tgtttttaaa gtattattct atttaatctt accatatgga
     3061 attatgtcga caattccgac tcaaattttg gctgggacaa taacaattaa tggattaata
     3121 tactcaattt taattgtatt tttgtttaca ttgtttatgt ggagattttg gaagttaggt
     3181 atgagacatt ataaaagtgc aagtagttaa taaattagta aaaatagaca atgtataact
     3241 atatataaat atgtttcata tgacactaaa ctatgtgaac aagtatttgc gctaaaggca
     3301 ctgaaagcta taaaattatt aaagtaagga tttaaaagtt tctttagtag aaatataatt
     3361 gtgtaaaaaa gcaagattaa ttaaaactat atccaaataa ttagatataa ttcttatgca
     3421 gaaaggaggt ctgtaaatgt ctaattgttt ggaatatatt ttaaaaataa ttaatgtaca
     3481 gaaaaataaa caaaatgagt gatgtatatt attcagaaaa tcatgaacaa gataatcttt
     3541 atgagcaaga taatttactg gcacaaagat ttaatttatt taccctattg aagtttgcat
     3601 ttcctactat ttttatgatg atttttatgg ggttgtatac aatcgtagat actatatttg
     3661 tatcaagatt tattaataca aatgctctat cagcaattaa tattgtatgt ccaattatta
     3721 atcttatagt tggaattgga actatgcttg ccactggagg aagtgctatt gtagcacgta
     3781 agatgggaaa tggtgatatt gagggagcaa ataaagcttt ttctttaatc gtattatcag
     3841 gagttgtaat tggtgtaata attactggta taggtattgt atttatggat tatatcatta
     3901 tatggttagg agcaagtgaa gttttaatta aatattgtcg ttcatatctt tttattatct
     3961 tggtttttgc ttctgcaaat atactacaag tattatttca atgtttattt gtaacagctg
     4021 gaaagcctca atttggatta tggctagtgt taggtgctgg gtgtgctaat ataattcttg
     4081 actatgtgtt cattgttctg ttacaaatgg gtattagtgg agcagcactt gcaactggag
     4141 taggatacct aattcctacc gtttcaggta tggttttctt ttcaaaaaac aaagggttac
     4201 ttaagttttg tatacccaga ctagataaaa gaatattatt tgaagcttgt tttaatggtt
     4261 catctgaaat ggtcagtcaa ctatcaacag cagttactac ttttttattt aatgctatga
     4321 tgatgaaatt aattggtgaa gatggggttg cagctattac aataattatt tattctcaat
     4381 ttcttttaac ttcgctttat ataggtttct caatgggtgt tgcaccaata ataagttata
     4441 actatggaag tgaaaataat acgcagttaa atcatgtttt taagatttgt atattattta
     4501 tttcagtagc atctttattg gtatttatct tttctatatc atgttcacca atcattgtag
     4561 agattttttc tcaaagagga agccgagttt atgaaattgc aaggtctgga ttttatatat
     4621 tttcttttag ttttattttt tgtgggtata atatttttac ttcgtctatg tttacagcat
     4681 tatcaaatgg aaaggtgtct gcaatattat cttttctacg tacatttgga tttataacta
     4741 taggtttatt gatattgcca aatatattaa atataaatgg gatatggtta gcagtaccaa
     4801 gtgctgagat tttaacttta tttttaacca ttttttgtat atgtaagtat aagaatagat
     4861 ataaatatat gtagatatta aataaatagt ttaggtagat attttatgtt ttaataagta
     4921 attcaattag tgggagatat atactattga aaattaaagt tataattgat ataaagaatt
     4981 aataaaaata acatataaaa gtttaaaagg gagttgaact taaagtttga ttagaaaaag
     5041 tcaattttaa gacaactcct tttattttac tattgtatta atctgtatct gtaagtgtat
     5101 tagtctaata ttataaactt tggatgaaat taattttcta taggttttaa tgtatcatac
     5161 actttatttt aaagaaactt atcttaattt tcatagtgat tgaatttgtc tattagagat
     5221 gttactatta gtaatgtaaa agcaagagta gtgaatataa aaaacaagat agtgatactg
     5281 caagattaga atataataaa tttttatgga gagatttcaa tatggataca tgttttaata
     5341 aaaaaatatt acttgttgat gatgaaaagg atatagtaga tttaattgaa gaagtactca
     5401 taaatgatgg ttttaaaaac attattaaag cttataatgg tctagatgct atttcgctgt
     5461 gtaagatagc atgtccagat gttgtcattc ttgatataat gttaccagat atagatggta
     5521 tagaagtgtg taaaaaaatt cgagagtttt catactgttc tattcttttt ttatcatcaa
     5581 aaaatgatga tattgacaaa atactaggtc ttagtagtgg gggagatgac tatataacaa
     5641 agccattcag tccaagagaa attgcttttc gagttaaagc gcaattacgt agacaacagt
     5701 atcaaagcat tgtaccatca gatagtgaag ttattaaaat aggagatatt actattgata
     5761 tagaaggaaa ccgtgtatat aaagatagaa atgagattga gttaactgga agggagtatc
     5821 atcttttaag ctacatggct caaaatgtaa ataaaattat aggaaaagaa agactctatg
     5881 aacaagtatg gggagtatat agtagtattt gtgacaatac aattatggtg catatacgac
     5941 atataagaga aaaaattgaa gataacccct caaatcctaa aatacttata acagttaaag
     6001 gactaggata taaacttgtg aatagaatcg attagaatag attttaatat taatgaagat
     6061 atctcaagtt gaatttttag ttaatgaggc attcttttat gggtgaaatc aaatgtattt
     6121 tcgttatctc aacaatgaag aagaggtcta tctctatttt gagatagcct cattaagttt
     6181 atatcctggt aatgtacttt atgttctaat aaaatttttt tagtttattt gcagtgaaac
     6241 attaactaga acattaaaat ttgcattgaa ataccaatta aataatattg tatattgtgt
     6301 ataaacttat actaattgtt tttctatatt aaatacttta tcaatccaac ctttataaaa
     6361 tttttcttca tgggaaacta ggattatact tcctctaaac tgtttcaaag cattttgtaa
     6421 agcatccttt gtctctgcat caaagtgatt ggttggttca tccagaataa gaaaattaca
     6481 aggagataac atcatacaac ataatttaac cttagattgt tcaccaccac ttaaagtaga
     6541 tacactcctt gaaacatgct cttccttcac accacatctg gctagatgac gtctaatctc
     6601 ttttgtattt aattttggat atttatctgc tactatttga agtggggttt tatcaggatt
     6661 ttcccatttt aaatcttgct cataataacc aattttaact tgttctgaaa actggaaatc
     6721 tccagatata cgaggaatat ctttgactaa tgtctttaac aaggtagatt taccgattcc
     6781 attaaaacca gttataacta ttttttgacc tccatcaaca gagaaattta attttggaag
     6841 taaagaatag tagtatccaa cttcaagatt tgttatagta agagcatttt gagccgatat
     6901 ttcaatttct gaaaattgaa tatttggttt tcctgtaaaa ctaggaggag ctattctttc
     6961 tattttatcc aattgttttt gtcttcctct tgcaattttt gaatttactc cagctttatt
     7021 tttacgtata aatgtttctt ctttttctat tttcttttgt tgtgcttgat accttctaat
     7081 ataatcttct cttaaatgtg atttttgttt aaggaactct gaatattttc catgatattt
     7141 cttaatcatg ccaaattcta tatcaagaat acctgtagaa attttttcta aaaagtcaaa
     7201 atcgtgggaa actacaataa atgccccatt aaatgtattt aaataatttg agagccattc
     7261 aacatgctct ttatctaaaa agtttgttgg ttcgtctaat aatagaacat catggttaga
     7321 aagtagtaat tttgctaaaa ttacctttgc cctttgacca ccactaagct ctctaacaac
     7381 acgattcatt cctattgaat ctaatccaag accatttgct attttattta tttcattatc
     7441 tatagaatag aaattacttg ctattagttg ttcctgataa tctgatgctt tgattagata
     7501 ttgctcattt tcagatatag cacttttttg atagagtaaa ttcatttcct tttctatttt
     7561 ataaagttct tcaaatgcag tgtgtaaata gagtgatatt gttgtatctc tattgatttc
     7621 tgcatattgg tctaaatggc ctatattgat attaggttgc cacttgattt ctcctgaatc
     7681 tggaacaact tctcccaata aaattttaat taatgtactt ttacctgtac cattttggcc
     7741 aactacacct atatgttcac ctttgaataa atcaaagtta gctttctcat acagtgattt
     7801 atccataaaa cattgtgata aattagttac ttttaataaa ctcataattc aaactccttt
     7861 tcttttatta aaaaatttat ggaaataaaa aaagcagagg aatggcattg taaaatgccg
     7921 acctctgctt ttggaaaaac aaaaggtcat agacaagcat tgttgtctat gaccagaaaa
     7981 tctatattat ctatcggcaa ataggtaatt ttaaataagc atagccaaaa aactatacta
     8041 aacctatatt tgccgatgaa gatagaaagc tttaagcttt cagattaacc tctacacaac
     8101 gcttcatcgt atacatttgt gtagagttaa gttttctaac aagtttaact aattctatat
     8161 aaatcataat tattcacatc ctaatcttag tattaattct agtttatctg tatttaaatt
     8221 gtacttttgt actttgtgga ttatcttatt tatttaaaat atgttttatt aattatagct
     8281 taagttatgt tatcataata cttagttata gtcaataaga aagttatatt tactattatt
     8341 atattaattt agtaaatcta tcattacaaa gttatttgaa gactcgctat caataaaatt
     8401 ttatagtcta taagaaaatt aagattatga gttttataat tttgatatag ggatactatt
     8461 ttcataaata ttacaacatg tagaagtata tgtctattat tgttgaattt tcaatgatat
     8521 attaaggttc taatatatta tacaaaataa aaacattaat tcaacttaaa taattttaag
     8581 tattatatgt gttttgatta aagaaaacta aaattttaag gaaaaataac atatttgtat
     8641 taaattttat tgaaatgatt aaatttattt acttaatgta aattattagc taaaattgta
     8701 ttaaataatt aaggaggtga gtagctctgg atgaaataga tttaaaaata attaattctc
     8761 taaaaaagaa tagtagggct tcaacctctg aaataagcag acaaattaat ttatcagtac
     8821 cagcagtctc agagcgtata aggaaaattg agcagtcaaa tttaattcaa aagtacacta
     8881 ttcaaattaa tcgggaaaaa acaaaatata agcttttggc ttttatattt atcaatactg
     8941 atttatctaa aagtatgaaa gaatttaaga aaactatatt ggaatatgat actgtattag
     9001 aatgtcatca tatttcagga gagtatgatt acttaataaa agtattagca gaagatacaa
     9061 gtaatcttga agagtttata tcagtgactt tgaaggaaat tggggggatt caaaaagcta
     9121 atacaaccat tgttttatct acaattaaag aagaatttaa tacaataaaa gatatttttt
     9181 aaataattta ctagtaaagt gttaattata ttttaggagg aaaatagaat atgaaagttt
     9241 tagttttttt agcaaaaggt tttgaaacta tggaatttag tgtatttgta gatgttatgg
     9301 gatgggctcg taacgattat gggcatgata ttgatgtagt gacttgtgga tttaaaaaac
     9361 aagttatgag cacatttaat atacaagtat tagttgataa gacgatagaa gaagtatgtg
     9421 ttgatgatta tgatgctcta gctattcctg gaggatttga agaatttgga ttttatgatg
     9481 aagcatatga ttcatctttt ttaaatctaa taagggagtt taattcaaaa gaaaaaataa
     9541 tcgcttctat ttgtgtggca gcattgccag ttggaaaaag tggtgtttta aaaaatcgta
     9601 aagctactac atatcatttg aaaaatggta aaagacaaag acagttaagt gagtttgatg
     9661 taaatgtagt taatgaacca attgttgtag ataaaaatat tataacctca tattgtccag
     9721 aaacagctcc acatgtagct tttaagcttt tagaaatgtt gacatctaaa gaacaaatgg
     9781 atgaagttaa attagcaatg ggatttaaac tgtaatggtt tatagatttt ctaagtaatc
     9841 agaaccccag tcacacatgg aatctaaaat tggaataata ctctttccaa aatcagatag
     9901 cgagtattct acttttggag gaacaacagg ataaaccact cttataatta aaccatctga
     9961 ttctaattca cgtaattgtt gagttaacat cttaggcgtt gctttaggaa ttaatttttt
    10021 taattcattg aacctcaata tagtgtcttt aagatgccaa agtataagtg tcttatattt
    10081 accaccaatc aatgcaagtg ttgcttctat tgggcaactg taattatcta aacatttttt
    10141 catttttggg ctcctttatt tattttaaag tatcttttta ggtactatat tacaaaaaag
    10201 tgcattattg taatatagta ccatagtgat aaaattatag cataggttaa ataaatcatc
    10261 aacttagcct aataaaacaa tagggggtaa ataaatgaat ttcgttgaac ttgcaaaaaa
    10321 aagatattct tgccgtaatt atcaagatag aaaggttgaa aaagaaaaac ttgagaaggt
    10381 tttagatgtt gcaagaatag ctccaactgg tggtaatcgt caacctcaaa gattgattgt
    10441 tattcaggaa aaagaaggta taaataaact ttctaaggct gccaatatat atgatgcgcc
    10501 attagcaatt cttgtatgtg gagataaaga caaagtttgg acaagacctt ttgatgggaa
    10561 acaacttaca gatattgaca caagtatagt tacagaccat atgatgttac aggcaactga
    10621 acttggattg gcaagtgttt gggtgtgcta ttttaatcca gatataatta gagaagagtt
    10681 tagtttgcca gataatctag aaccaataaa tatattattg atgggatatg aatctaagat
    10741 accagagagc ccagagagac atgaaaaaac tcgtgttcct ttaagtgaaa ttgtttctta
    10801 tgaaactctt taattataaa attaagttat tcataggata aatgtaataa agtgtttgtt
    10861 ataaacaaaa ttcaaaataa ataatatcta catataatta attttagtga agtatatcta
    10921 gtttaactag aatgtatact tcactaattt atttattcaa aatatttatg aggattttaa
    10981 tatattaact aaaatatatc aattgaatta acttttaaat ctggaaaagc acttgaaata
    11041 tagtgtttta tatcatttaa atggtcttga atttgctttt ctgatatttt atcaggtcca
    11101 tatacaaaat acataatatt tttagtatct tttgttatag ctgttcgatt atcagggcca
    11161 ttaagaatac tagataatat accaatatta tctgataaaa ataaatcatc ttttgttaaa
    11221 atatgttctt taccacctat accataaaaa tgttcacttc catttgctaa ttctattttc
    11281 aaaggtaatt ccattttatc aaggtcatga cctgctgtta gaagaagatt tttcaattct
    11341 gctaaaaaca ttgactcaat tgttacacct acatctggga taccttttga ttttaataga
    11401 atagattcta attgaagcaa tacagggtaa gttttcttga attttttata atactttata
    11461 taacttgaaa caggctctgt tttaattttt tctttgcgat tgtattctgg gtgttgttct
    11521 ataatatttt taattgtaga gtttttaaga actaaaaaat tttctttatt aggttttgaa
    11581 tgtgtaatat ttataaccat aactccaaat ttaatattgg gataaatttc tttaacttta
    11641 tgtgatacct ctaacataat atagactcct ttttatttta tattttatga tataatctta
    11701 gcaaattaaa agtggatttt atagttccat ttttatagta attttataga accacttttg
    11761 gaggtattag aatgtggatt acgattaata gaaatagtaa tatatcatta tcaagacaaa
    11821 tttattgtga gataaaagat atgattctgg atggaagctt aaagtttgag caaaaactgc
    11881 catcatctag gactttatca aaagaactat ctgtatctcg taatacagtt ttagatgcat
    11941 ataatcaatt aattgcagaa ggatatttgg aaacaaggaa tggatatgga acaattgtag
    12001 ctaaaggaat atcagggcat aaagttgatt ttaagttaaa tgatactttt agagatgaaa
    12061 aagatttaca tactaataaa caaaaaaatt atatagattt tcgttcagga gttccagaat
    12121 taaaactatt tccacgcaaa gaactttcaa agctatataa acaaatactg tatgatttat
    12181 cagattcgga tttcagatat ggaagtacag ctggtgtatg ggttttaaga gtggaaatat
    12241 ctaagtattt atttcgtact agaggaatta gatgtaatcc caaaaacatt atgattgttt
    12301 ctggttcaac acaaggttta tctttaattt cacagctttt atacaaaagt aataaaaagg
    12361 ttgctgtaga agaccctatt cataaaggct tattaaaggt tatttcatct attggatatt
    12421 cagttgttgg aattaaagta gatgataagg gaatgaatac caacttaata aaatcaataa
    12481 aggggatttc ttttgtttat actacacctt ctcatcaata cccattagga gggattttac
    12541 ctattcaaag aagactagag cttattaaat gtgcaacaga gaatgattac tatataattg
    12601 aagatgatta tgatagtgaa tttagatatg agggtcaacc aattagttct ctttatgaac
    12661 ttagcccaaa taaagtaatt tacataggtt cttttagtaa aatattatct ccagctattc
    12721 gtgttggatt tatgttatta ccagacaata ttttagaaag ctataaaacc ttaaaaatgt
    12781 actctgatgt tcatacagaa acaatattgc aacatgtatt agctgaattt attggaaatg
    12841 gaggtttaga gaagtacata tttagaatga agaagttgta caatagaaaa cgtaagtacc
    12901 tcataaaagt tttaaacacg gaatttaaaa atgaatttaa aataaaaggt gaagcagcag
    12961 ggcttcatat agttgctcat ttctataatg ttaaatttac ggaaagttta attcataaaa
    13021 tttttgaagc aggtataaaa gtttatccta tacaacaata tgcaattgag aatatattag
    13081 aatatgacta tgaaattata ctaggttatg ctcatcttag ttttgatgaa attgaaaaag
    13141 gtgtaaaaat actcagcaaa ataatacata tgaatcaagg tacatagata aaacatgtag
    13201 caatctacat ataatagatg taattaagtt taaactttaa aagaaatata tattaatatt
    13261 tttgtataaa aatacctgat atttttttat cgatacttta ttgctataca ctaaattaag
    13321 atagcaattt atattaagaa aaaacttttt gcataggtta taatacttaa aaggagagga
    13381 tagagttgaa aacaaataca gatgttatta tggagataat tgattatata gaagaaaatc
    13441 ttacagaaaa tctaaattta gataaaatag cttatattgc taattattca aaataccatt
    13501 tacacagaat gtttacaaat gttgtaggat gtactatcca tcaatacata cagaggagga
    13561 gacttactga agcagctaga caacttatat ttacagacaa atatattata gacatagcta
    13621 ttacagtagg atattctaca catcaatctt ttacactagc atttagaaat ttatataaag
    13681 aatctccaca agtatataga aataaagatg aattttatcc tattcaacag agatttgttt
    13741 taaatctaaa tcatcaaatt caaagtgaaa aatgtatttc ttatgcaaat atgaattata
    13801 aacaaagaag agatgaaatc aattcttatc ttaactttaa tattaattgt gaggtgaaag
    13861 tagcatgagt ttagtgccac atgtaattga acaaacaggt caaggggaaa ggtcttatga
    13921 tatatattca aaattattaa aagatagaat tatatttata ggagaagaaa ttaatgatgc
    13981 tattgcaagt ttagtagtag ctcaattact gtttttagaa tcagaagacc cagattcaga
    14041 tataattata tatataaata gccctggtgg ctctgctaca tcaggatttg ctatatatga
    14101 tactatgaat tatgtcagat gtgatgtatc gactatttgt attggtatgg ctgcaagcat
    14161 gagtgctttt ttacttgcag gaggaacaca tggaaaaaga tgtgctttac ctaattcaga
    14221 gattatgatt catcagccaa tgggaggagc taaaggtcaa gcaacagatg taaaaatagc
    14281 tgtagataat atattgaaaa taaaagaacg attagataaa attctttctg aaaatacagg
    14341 taaatcaata gaagatatta ggagagatac agatagagat aattttatga ctgcactaga
    14401 ggctaaagag tacgggctga ttgattatat aatgaatagg aatgaataaa gtatcaaagt
    14461 atcatattaa aatgtctgtt ttacaaatat atatataata ttaaataaga gtgtctcaaa
    14521 atgaactttt tagtttatgg gacactcttt tttgtatgaa attaaatatg gttttatcat
    14581 ttcaacaatt attaccaaat ttcaagttta ataaattcta ctataaaaaa tacataaaag
    14641 ataaggttct ttagtaactt tctgtcgtca aaagttttta taaatttaat aacaaaacaa
    14701 gagaaaatac catatattac ttatgtctgc aatatataga agacaaagga gttgtacatt
    14761 atgattacaa taagtttgtg catgattgtt aagaatgagg aagaagttat aggcagatgc
    14821 ttagaatgtg taaaggatat agtagacgaa attataattg tagatacagg ttctacagat
    14881 tccacaaaag aaatagtctc aaaatataca gacatggtgt acgatttcga atggatagat
    14941 gatttctctg ctgcaagaaa tttttcattt tctaaagctt ctaaagacta tactatgtgg
    15001 cttgatgcag atgacataat tttagaagct gatagagaaa aattattaaa gattaaagaa
    15061 agcttggata cttccattga tattgttatg gcaaaataca atgtatcctt tgatgaaaat
    15121 ggtaacccaa ctctctcgta ttatagagaa cgattgttta aaagaagttc taatcataaa
    15181 tgggttgacc ctattcatga agtagtacct ctttttggag aggtatttta ttctgacatt
    15241 gcaatatctc ataaaaagct tcatagacag gaccctctaa gaaatcttag aatttttgaa
    15301 aaaatgattt cagaaggaaa aacattggag ccaagacacc aattctatta ttctagagag
    15361 ttgtactata atgctaggta taaagaagca atagaaggtt ttactaagtt tttagactca
    15421 tcaagaggat ggattgagga ttgtatcagt gcttgcagag atttagccac atgttattac
    15481 ttaattaatg atgaaaaaag tgccttatat tcattgttta gaagtttcga atttgatgag
    15541 ccaagagcag aaatttgttg tgacatagga aagcatatgt ttgatagaca aaaatataaa
    15601 gaagccattt tttggtataa ggtagcatta acaagagata agaatgatac taatggaggt
    15661 tttaagtcaa atgattgtta tggatatata ccatctatac aattaagtgt ctgttatgac
    15721 aggttaggag aatcagataa agctatttat tatcatgaaa aaacaaaaga aatcaaacct
    15781 aacgatagtg ctgttttgca caatgaaaat tattttagta aatttaaaaa tagttgatag
    15841 gtcacaatca tactaaattt gacatattat atatagagct taaaagctca aatatatcag
    15901 gaggtgcttt taataatgag tagaaataaa tattttggac catttgatga taatgattac
    15961 aacaatggct atgataaata tgatgattgt aacaatggtc gtgatgatta taatagctgt
    16021 gattgccatc attgctgtcc accatcatgt gtaggtccaa caggcccaat gggtccaaga
    16081 ggtagaaccg gcccaacagg tccaacgggt ccaacaggtc caggagtagg ggcaacaggc
    16141 ccaacaggac caaccggtcc gactggtcca acaggaaata cagggaatac aggagcaaca
    16201 ggattaagag gtccaacagg agcaacaggg gcaacaggcc caacaggagc tatagggttt
    16261 ggagtaacag gtccaacagg cccaacagga gcgacaggag caacaggagc agatggagta
    16321 acaggtccaa caggtccaac gggagcaaca ggagcagatg gaataacagg tccaacagga
    16381 gcaacagggg caacaggatt tggagtaaca ggtccaacag gcccaacagg agcaacagga
    16441 gtaggagtaa caggagcaac aggattaata ggtccaacag gagcaacagg aacacctgga
    16501 gcgacaggcc caacaggagc agtaggagca acaggaatag gaataacagg tccaacaggt
    16561 ccaacaggag caacaggagc agacggagca acaggagtaa caggtccaac aggggcaaca
    16621 ggagcagatg gagtaacagg tccaacaggg gcaacaggag caacaggatt tggagtgaca
    16681 ggcccaacag gtccaacagg agcaacagga ataggaataa caggagcaac agggttaata
    16741 ggtccaaccg gagcaacggg agcaacagga gcaacaggcc caacaggagt aacaggggca
    16801 acaggagcag caggactaat aggaccaacc ggggcaacag gagcaaccgg agcagatgga
    16861 gcaaccggag cgacaggggc aacaggagca acaggtccaa caggagcaga tggattagta
    16921 ggtccaacag gagcaacagg agcaacagga gcagatggat tagtaggccc aacaggtcca
    16981 acaggggcaa caggagtagg aataacagga gcaacaggag caacaggagc gacaggtcca
    17041 acaggggcag atggattagt aggtccaaca ggagcgacgg gagcaacagg agcagatgga
    17101 gtagcaggtc caacaggagc aacaggagca acaggaaata caggagcaga tggagcaaca
    17161 ggtccaacag gggcaacagg tccaacagga gcagacggat tagtaggtcc aacaggagca
    17221 acaggagcaa caggattagc aggagcaaca ggagcaacag gcccaatagg agcaacaggt
    17281 ccaacaggag cagatggagc aacaggggca acaggagcaa caggtccaac aggtccaaca
    17341 ggggcagatg gattagtagg tccaacagga gcaaccggag caaccggagc gaccggagca
    17401 acaggtccaa caggagcaac aggagcaaca ggagcaacag gtccaacagg tgctagtgca
    17461 ataatacctt ttgcatcagg tataccacta tcacttacaa ctatagctgg aggattagta
    17521 ggtacaccag gttttgttgg ctttggtagt tcagctccag gattaagtat agttggtgga
    17581 gtaatagacc ttacaaacgc agcaggaaca ttgactaact ttgcattttc aatgccaaga
    17641 gctggaacaa taacatctat ttcagcatac ttcagtacaa cagcagcact ttcacttgtt
    17701 ggctcaacag ttacaattac agcaacactt taccaatcta ctgcaccaaa taactcattt
    17761 acagctgtac caggagcgac agttacacta gctccaccac ttacaggaat attatcagtt
    17821 ggttcaattt ctagtggaat tgtaacagga ttaaatatag cagcaacagc agaaactcga
    17881 ttcttactag tatttactgc aacagcttca ggtctttcat tagttaatac tgtagcagga
    17941 tatgcaagtg caggaattgc aataaattag attagataag aaaaggcttc taatatcgta
    18001 ttgatattag gagctttttt aagaatgatt gatgaacata gttttaatat taattagtgc
    18061 gcatattata aaatactatt atataatata aaataataac attaaattgg aaatatagaa
    18121 ttatctaggg gtgatactat gaaaaataag attgaaatat caatgaacaa ctttgtaaaa
    18181 aattatcata aatcaaataa tataactaca aagtggcaag aacttttgtt tgcttatgca
    18241 tctgctgaag atgatatgtt tcagaagcta aaaagtgttg taggaacatc tcatgctatg
    18301 ccaaaagatt ttctggaaaa tggaaaaact ataattacat attttatacc ttttgatgaa
    18361 agtgtaaata atagtaatat tggagggttt gaatgttctg aaatatgggc aagagcgtac
    18421 atagaaacta atatgttgat ttcaaattta aatgatttct tatgtgaaga actagagaag
    18481 atgggggcta attcatatgc tattcctggg tcgtataatt ttgacagtga aaaattggta
    18541 agtgactggt cacaaagaca tgtagcattc atagcaggtc ttggaacttt tggtttaaat
    18601 aatatgctta ttacagaaaa agggtgttgt ggaagaatag gaagcataat cacaagttta
    18661 gaattagagc caactaaaag accagaaaat gaatactgct tgtataaaca taataatagt
    18721 tgcaaaaaat gtgtcaacaa atgcgtgaaa gaagctttaa aagaagatgg atttaatagg
    18781 aataagtgtt atgaaatgtg tatgataaat gaaaaaaaat acacttatat aggtggatgt
    18841 gatatttgtg gaaagtgtat agttggagtt ccttgttcag taataaaccc atcaagataa
    18901 tggatttaag ttgactaata attttaaaga tagtttataa tgaaaaaatt ttagttatca
    18961 aaataaatat aatataaaaa ctaaataaat gtgtttaaaa aatggataaa taatttgtgt
    19021 tgattgacaa ccagttatac tgttgataga cttatatgta tcgctgtgat atataaggag
    19081 ggttgagatt ttatgtttga tttaatcttt atttttgcat agcaagggct attgcaacta
    19141 tgaaatttaa tatataaata gccctttgct attcctaatg aaaaattact atttaatagg
    19201 agagcaaaat gagctataaa aaagcaatac atatattacc agaagaatta cttgaattaa
    19261 tacaggaata tgtagatggt gaatgtatct atattcctag aaaatctaat aataaaaaag
    19321 aatggggaag taatacacct actcgtgagg agttgtcaat tagaaatatg cagatttacg
    19381 aagactatca agttggatat gatttgcaat atttatcgga aaagtattat ttatctttga
    19441 aaagtatcca aagaattgta ttacaagaaa aaagaaaaga tatctaagga tgagccagta
    19501 tagttttata attatactgg ctcattttct tttgataaaa gtgtttgagg tatagtttct
    19561 tttaagtgga tgatataatt taagtaattt caataactta tacagtagct aacaaagctg
    19621 gttgtaaagt atctaataag aagtagtagc tttttatatg tttgaaatta aaatttatta
    19681 aaattaggag gtcttgtttt gaaaaaaata cttgattata ttccaccttt tcataacttt
    19741 ctattaattt agtaatctta tagaaaggaa attgcattta tgaaaaaaat tacttgggag
    19801 gtggaatata tctcccagtt acctgtaatt aggtattgta aaaaatgtgg aaaaaagact
    19861 gaatatattt gttcaggttt atttagggtt aatgctcaac ataaatattt ggatatatgg
    19921 ttaatataca agtgttcaaa ttgtgattca acatggaact caactatata ttctcgtgtt
    19981 aatccaaata gattaagtac agaaacacta gaacaattcc atacaaatga tgataatctt
    20041 gctaatcaat atgctatgaa tgtagaactt ttacatagaa atggagcaga ggttggtatt
    20101 ccagaatata aaatagtagg acaagaaatt gatattaatg accttacaca agttcgtatt
    20161 gtaagtaagt atccatccca attaaaggtg tcagcattat tacgtgaaaa actaggttta
    20221 tctaggaaag catttgatga aatgttagat tgtgggacta ttaaaagtat atctggagtt
    20281 gatttaagga gaagtaaatt aaattatgaa attgtgttag aggtaggcaa gcagaagcaa
    20341 aagtcttcaa actgattaga ataactaact taatatattt tcaggaacat catttaaaaa
    20401 aatagtgact ttaaaaaatt taaagccact attttttaat atgttttata tgagtattta
    20461 aaataaagtg tgtattcttc aaatttatag cgataattaa aacattacta taaaaaggaa
    20521 ggtgcatact ttttatttaa caaaaactag atattaaaaa cttttcgagg aatattttat
    20581 taaaatccct aaatatattt aatatatatt aaaaaattgt attataatga aaatcaaaat
    20641 agattgcaaa tccaaaaagt aatacttaat gtccaaaaag ctaaaattaa aatctaaata
    20701 gctatttact acagaagtat gttaaaatat gtaaaatgaa tagaaattta tatattttta
    20761 ttaaaaatat ataagaaagg atgtttaaga attgtgatta atataggaat atgtgatgat
    20821 gaactacatt atcgaataaa aataaaagat atattaagtg aaatattaag ttcatatcct
    20881 ataaattata acatatatga attttcagca ggagaagagt tactaaataa ctatcctaaa
    20941 gatttagaca tattaattat ggacatacaa atgaaaacaa taaatggtat ggatactgct
    21001 aggaagataa gagagtttga tcataagtta gaaataatat ttgttacttc atttgtagag
    21061 tttatgcaag aaggttatga ggtaaaagca tacagatata tactaaagcc aataaataaa
    21121 gaaaaaattt ctaaaagtgt attaccttgt ataaatgaga tgatgaaaaa gagaaataat
    21181 tacttaacta taaatgtaaa aaattatgta gaccgaatta aaatagattc tattacttat
    21241 atagaaacag atagaccgaa tatattgatt tatacacatg atgatatgta tattactaaa
    21301 atgagtatat ctaaaataga aaagatatta aatgaatatg gattttttag atgtcataat
    21361 agctatatag ttaacttaaa attagtagaa tcaatgagtg gaagtactgt tatagtagat
    21421 ggaaaaagta ttccaataag taaatatagg gttaaaggct tgaagcttgc gataactaat
    21481 atattagggg acatagtatg ctaacaaatt taagtgtagg attttggaat attattaatt
    21541 tagtttcagg tactatagat tggattatat tttttttagt aatccactta gttggaaaga
    21601 ggaaaatatc taatataaga tatatattta caacaataat tataattata tttatggcat
    21661 acataaatgt agttaaagtg tttccaaata ttaagattct tctatgtatg gtaataggaa
    21721 tatcatttta tataacatca tatgaagata aaatctataa aagtataata gttagtttat
    21781 tgttttggct aggattaatg gttgctgaag gttctgcagt aggtctagta gtatttataa
    21841 ataaattaaa taatattaac ataacacaac atgaaaactt atttagaata caagctatta
    21901 ttatgtcaaa ggtattttta tttataggtt ttatattgtt taagtatttt aaattatctt
    21961 tagattttaa acctaaagat atgatactaa taggaatacc tatattatct aatatagtta
    22021 gcttattact tatatttgaa tataatttaa gagtcaatac aattactaca gaaaacttat
    22081 ttatatttat atttgcaatt ttattgattt tatcatcaag tataatactt ttaatagtaa
    22141 tagggaaaat tgtacaagac gataaattaa atctagagta tgaacttata aatgaaagaa
    22201 taaaaacaaa ctacaggaat tatgaaaata taaacgaagt tcatgataga ttaaaatatg
    22261 tttatcatga cttgaaaaac catatgattt gtataaaaaa ttatgacact aaagaagaaa
    22321 ttatatcata tataaataac ttagagtttc agataagtga atttgaacat tttaaaaata
    22381 ctggaaataa aacattagat ttaattttag cagaaaaaat aagtatttgt aaaaagtatg
    22441 atattcaaat tgaagataac ataaatatat ctaaattaaa ctttattaaa aataatgata
    22501 tatgttcaat atttgcaaat tcactagata atgcaattga agcatgtatg gatataaata
    22561 atgagataga aaaaagaata gaagttaaag ctacatatat aaataaattt gcaataataa
    22621 aatttataaa tactaaggta aatgatatta aacttattga taaacgtatt caaactagta
    22681 aggatgatga taatatacat ggaataggac ttgctagtat taaatatata gtaaataaat
    22741 atggtggtga aacaatagtt aattactcag ataatgagtt tatattaaaa ataatgatac
    22801 caataaaaag ttaggagagt acaaaatgaa aaaaatagcg ttaaacttac ttaaaaacat
    22861 ctcagcatta agttttggga tagctgtatt atcagcaaac agtgcaagtt cttgggtagc
    22921 acatcaggca aaagagccac aagctttaca aaaactaaaa aaataacatt aataaaagga
    22981 cctcttctta ttaaaggaga ggttttacat gttgaggagg aaatatgttt aaaagattat
    23041 catataaatt tgccaatata ttagttaata atgagattgt agaaagtgaa gattttgaaa
    23101 tatatagata tggatttgaa actttgattt atttcatagt taatattttg gtagcattat
    23161 ttataggaat tatttttgat agatttatac atacagttat atttttaagt tgttattgca
    23221 ctttaagaca gttcacagga ggttatcatg ctaggaatta taaagagtgt acattaacat
    23281 ttgtagttat ttatttgata actatttttt cagctaataa tatagatata aataaatata
    23341 agtatttatt agtattatta atgattatta gtatactaac aatttacaag ttagctcctt
    23401 tagaacatag aaacaaacct cttagtgaaa gtgagaaaaa gcattataga aagactgtgc
    23461 aaaaaatact attcgtaata atatgtttaa ttattttatg taaaatactt aatatttttc
    23521 agcaatatgt gatttatgca ataatttcta tatattggat tgctatatta atatatattg
    23581 gaatgaaggt taatagtgat cagtaagatt ataaaacatt ttctaaatta attaacttca
    23641 ctaattaata ttaactttaa aaaaataatg tcaaggtaag tatttgaact tattaaatat
    23701 agttgaatct attgtgggtt gtatcaaagg acaaatagat tcacttaata accagtttgt
    23761 aacagagtat tgaattgtaa aagttaatac gatagtatga aaatgtaatt tgaaattaca
    23821 tttttataaa aattatatta actaagggga gggatacata caatgaattt gaagaaaaaa
    23881 attaaaaagt taggagttac atttgcaata ggaactataa ttgtatcaag tttagggaca
    23941 tctgtatttg cagatgaggt tagcacatat gctttaatat ctaaagcttt ttcaggtaaa
    24001 aacaatatta tatctagttc agtatacact tctggaagta gaacctttaa aacgacagat
    24061 tctcaagggg gattttcttg taggctaaca gaaagattct caggatctag cccagataga
    24121 attgtaaaaa gacatgaagc aaatgcttct tcaaaagtta gtttatcagg aggaacatac
    24181 tatataaggt atgaaggttc aacgaataat gctaaaacat atgcaacttt aaattagtat
    24241 taaaagcatc ctataattat ttttatagga tgtttttgta attgttataa tcaaaagact
    24301 ggctaggagg ggcataaata tgagtagtat taaggttata tcagacttta taaccaaaat
    24361 aattagaaaa aatattttat ttgcaataac aattattatt ataaattacc atctcataca
    24421 acgatggaca catatatcca atagaggaat ttcatttaat gattacttat ccttgagtgt
    24481 atatacttgt atgacaatta gtattttaac catgttaaat gtaatttttt atatgagaaa
    24541 aagttatgat actgtaaaaa tattatgtag aaataatttt gattattttt taggtatttc
    24601 tgttgctgta actagaaaca actttatatt ttgttgcata ccaattatat atgctatagc
    24661 atactcaagt ttaataagaa cattgtcaat tgtaacgatt aaatcaacta tatttatatt
    24721 gatatttgaa tggtttttac cacttactat tttatctata gtgatatcat ttatttcagt
    24781 tattataaat aatttaatac taaagattac cttatcatca gtatttttat atttaacatc
    24841 aactaatatg ttggatagag ttattgatat taaagaacca ttttttaaag cattatttaa
    24901 atcacttaac atatttgaag atcaatcata tgcttactat tctgattttg tagggaaagt
    24961 taataattca gcatatgtta tagataagat tatacctaca ctatttgcaa ttactttaat
    25021 aatagtagca tatctgatat taaatgatat tagaaagaaa cagattaaat cattaatagt
    25081 tatagtagtg tacagtattt tatttattgg attaaattat atatcaatag atatgtcaac
    25141 atatagagat gaggagcgta gttatggaga gtatttaaag aaatctaata ttagtgatat
    25201 taaaataaaa tcgcatgata tgaagattga ctttaaaagc aagtcaaata taaaagatag
    25261 aattgtttta ttaaacacat caaatgaaga gttaacaaat attaatatga ttttagatga
    25321 aatatttgat ataaaatata taaaaataaa ttcggaaaat ataaaattta acaaaaaaaa
    25381 ggatttaatt gaagttaatt taaaggaaag tttagagcct aatgacgagg tgacattaga
    25441 tatagagtat gaaggctata ttaatgtgtt gacatcttgg aatcaaaata aatatatagc
    25501 tactaaagat gatattatgc ttccaccagg ttctttagcg tggtacccaa aagtaaatca
    25561 atcaagttgt atggcttata aaataaattt aagttctaaa aataatgtct attcaaattt
    25621 acctttactg aataagacta gtaatttttt aaaaaaagat tatatatttg aaggaaagtc
    25681 aaatgatatt gcaatatatg caggtgagtt taaagaagag gtaaaagatg atataaaaat
    25741 aatctatcca tcagatagta atgtaaatat ggatatagag gaaaaaatta aatttttaat
    25801 tgaaacaaga aatgaaatat taggtgatag caaagcatct gtagatgcta aaaaatatgt
    25861 agatgaagta gataatgtta tggaatcaat aaaaagaaaa aaaattaata tgatattagt
    25921 tgctgactta cctagcaatg aatttttata tgaagactca aagggagaga aaattagcat
    25981 aactatttat cattggcttt caggaaatat ccttataata gataaataat aaaggaggtt
    26041 aatatgataa acaagttaga aataagaaat ctaaatttta attacaaaaa taaaaaagct
    26101 ctggataata taaatttaac cctaacagat ggagtagttg cattattagg tcctaatggt
    26161 gctggaaaat caacattaat gaggttatta gtgactcttt atgaaacttc aattggagag
    26221 atagaattaa ataatataaa gtatagcaaa aacaatgaga aaatcaaggc aaatgtagga
    26281 tatgtacctc aagattttga tatgtataat aatataaatg ggcaagaata cttagaattt
    26341 gtagctaaaa tgagaggtgt atctaagaat gatttaaaga aacatataca aaaagtagta
    26401 tcaaaagtta atctggacaa gtttataaat aaaaaaatag gtacatactc aggtggtgta
    26461 aagagacgac taggtatagc acaggcttta ataggtgatt ctaagttaat agttatggac
    26521 gaacctacag ttggtcttga tccagagcaa aggaatgaat ttagaagatt gttaccagaa
    26581 ataagtaaaa attctatagt attaatttca actcacatag tagaagacat acaatttaac
    26641 tgtgacaaat taattatatt aaatcaaggc aaaatattat atgatggtac aattaataag
    26701 tttattgata tggttgaggt gtattcggta gtagtttcta atgatgaatt tgaatattta
    26761 gaacgtaata ttgatattat tgattatagg agagttaaag atggtgtgca agtaaagtat
    26821 ataggtaaaa atacagagaa acttaaagat agcttaagga tagatacaac tttacaagat
    26881 gcttatataa actttttaca taaggagtta aaataaatgt gtatattgga gttaataaaa
    26941 tttgagctta aaaaaataga gcttaaacat gtgttaatat ttgtaattat ttctatatta
    27001 tgcatattta ttacaggcat attagattat aatgagttaa tattttataa tgatgtacct
    27061 ataatggata catattctat agcaggatgg ttaggaatta taaagatatc agatgttttt
    27121 ataccaataa tgtcagcaat cacaataatt tatgtgtttt caaaagatta ttcgggtaat
    27181 ataaatgaga tacttacttt atataataaa aaaaaatata atcaatttat agtatttaga
    27241 tggtgtgtta tattagctat atatactgta ttattattaa tttcaattac aatagtatat
    27301 acatttacgt cagtgaaagg ttttaacata gacaaaatag attttgttta tagtgtaaag
    27361 ccaatagatg tgtttttaaa gacgtttcct acattattat ggtatacaac atttccacta
    27421 atgatattaa cattaacaaa aaatagattt acaacaatag caatattaat tacatataca
    27481 tttgctgata tattttttat tttacatatg tacccatttg ttagtatgat taatgtaaat
    27541 ggattttata ttcaaaagat gttttatatg cctaacaata tagatgttag atttaatgaa
    27601 ttaaagaatt atttctttat aaatagaggt tctctagtag ttatttctat aataatagtt
    27661 ttttatatag caagaaaatc aacggtttta aaaaagagta aatagtttaa tatatttttt
    27721 atattgttat atttatata
//
LOCUS       DAEQCW010000043        27419 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.043, whole genome shotgun sequence.
ACCESSION   DAEQCW010000043 DAEQCW010000000
VERSION     DAEQCW010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27419)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27419)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27419
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.043"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(38..529)
                     /locus_tag="KRO40_001897"
     CDS             complement(38..529)
                     /locus_tag="KRO40_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092717.1"
                     /translation="MSIKVAYGGVLLALNVILLTLTNIIPVNTLFIMGLASLLVSIVI
                     MEWGFKSGIAFYIGSIVLGFIVMASKSQWIVYSLTFGIYGIVKYLIEKDRSIYIEYFM
                     KLVFANIMILILYFLLRTIVYIPINIFIIGSFEIAFIVYDYVYSSFIGYYNNRLRKML
                     FKK"
     gene            complement(540..983)
                     /locus_tag="KRO40_001898"
     CDS             complement(540..983)
                     /locus_tag="KRO40_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092718.1"
                     /translation="MYSNTYNNENFMRARSFIENSEFKKAYDFLKTLTDKCAEWYYLT
                     GFSAMNIGYYEEGEDFLKRAKFMEPENSEYSDALRSYTQYRNDYSNRADNYNRRRRND
                     LDGCCCCCCDDCCCCLGDDCCENCAKLWCLDSCCECFGGDLITCC"
     gene            complement(973..1812)
                     /locus_tag="KRO40_001899"
     CDS             complement(973..1812)
                     /locus_tag="KRO40_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092719.1"
                     /translation="MFGYVKINKMDLTFREYDYYKAYYCGLCKYLKRNHGEISRFSLN
                     YDITFLIVLLTAVYNPESISTEEVCIVNPFKKKKVITNDITEYAASMNILLTYYKLED
                     NLMDDKRIKDKLAYYIYKNKLKLAYEKYPEKAEYIKQQLNELNKLEKDKNINIDEVSS
                     IFGNIMGEVFVYKKDENERNLRMIGFNIGKYIYLLDAYEDLDEDFKKGRYNPFIEYID
                     KNDELKEKVKKIIVTSLGFLARGIDNLNLNKNVGIIENIIYSGVYLRYINILESRGGK
                     NVQ"
     gene            complement(2031..3416)
                     /locus_tag="KRO40_001900"
     CDS             complement(2031..3416)
                     /locus_tag="KRO40_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2092720.1"
                     /translation="MDNLNKKFLMEYIDEIQGELRDISDKIWKNPELQYKEYYASNLQ
                     KECLKKHGFSIEGLEGMDTAFVASYGEGRPVIAVLGEYDALDGLSQKVSTTKEPIVDG
                     GAGHGCGHNLLGTGSIGAVIAVKELIKLKKLKGTIKYYGCPAEEDLSGKVLMIKKGFF
                     DGIDCAFSWHPFDINTPIRIPTLANYSVKFRYNGISAHAAQAPYNGRSALDAVELMNI
                     GCNYLREHIFDNCRVHYVTTNGGKMPNIVPDFAEVWYYIRGVKMEHVRDVFGRIVDIA
                     KGAALMTGTIMEYDIISGVYDYIPNTILTDILSQNMKLVGVQNYNEDDYYFADKLAET
                     VSIDKRSSVSSVLSGNKDITKMNLHDEVTDDTFTHNNCISLSLDIGDVSYIIPTAQCS
                     CSVWPIGISAHTWQSCASAGSDMGFKAMLLASKSISCSINDVMLDELVINKAKKELKD
                     TVGSFKYIPII"
     gene            complement(3589..4332)
                     /locus_tag="KRO40_001901"
     CDS             complement(3589..4332)
                     /locus_tag="KRO40_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytoplasmic protein"
                     /protein_id="HBH2092721.1"
                     /translation="MKKVLIVGESWVKNITHIKGFDTFVTTHYEEAVKWLKEAIESGG
                     YETVHMPAHVAADSFPYKLEELNEYDCIILSDIGSNTFLLSNSTFIDCNSNPDRLELI
                     KEYVNNGGALIMVGGYMSFTGIDAKARFGETAIKDVLPITMIDKDDRVEKPAGIIPEV
                     IDSEHPVLKGIPTEWPKFLGYNKTVARDNCPVLATIGGDPFVAVGEFGKGKSAIFSSD
                     CAPHWGPKEFTDWKYYNKLWVNMLDWLTC"
     gene            complement(4352..5614)
                     /locus_tag="KRO40_001902"
     CDS             complement(4352..5614)
                     /locus_tag="KRO40_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2092722.1"
                     /translation="MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGFEKEGQ
                     EYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNLGHNYQDRYNLICKYSDDLPGKT
                     IVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
                     LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVE
                     VKGVSLHCGSKWEGVNAIEKAMLLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGT
                     AGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLWLKDNKPNINIYQSG
                     LGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARVMKNLAEIPTLILGPGSIE
                     QCHSIDEYVEIKEYLDSILMYASLILNL"
     gene            complement(5798..6796)
                     /locus_tag="KRO40_001903"
     CDS             complement(5798..6796)
                     /locus_tag="KRO40_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose ABC transporter permease"
                     /protein_id="HBH2092723.1"
                     /translation="MSSITKHKEEKSSPLLTKLTSVFRDQGSAAVGLVIIFIIMSVAS
                     SNFLTLDNLINVGRQISINAILAVGMTFVIITGGIDLSVGAVIALVGTFWATTVVNYN
                     APIWVGMILALAIGTILGVIKGAIISTQKLPPFIVTLAMLTIISGASFVFTGGRPISV
                     NTDAFKMLGRGYIGPIPIPVIIMIIVVIAGHFLLKRTNFGRHVHAVGGNEEAARLCGV
                     KVNKVIVKVYALAGLLTALAGIILSSRLASGSPTVGDGAELDAIAAVVLGGTNMMGGS
                     GSIVGTCIGVGIIGILGNGLNLLSVSSYNQMIIKGLVMLFAIWINNIKLKKSAKSK"
     gene            complement(6780..8291)
                     /locus_tag="KRO40_001904"
     CDS             complement(6780..8291)
                     /locus_tag="KRO40_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBH2092724.1"
                     /translation="MSNIILKLSNIAKEFPGVRALDNVNFELFHGEVHALLGENGAGK
                     STMIKILTGAHSKTSGKFIFEGKEIENISPDISKKIGINAIYQELTVFDELTVAQNIF
                     MGKEINGKVLTNDKKMNEEAKKIFDNMGIDINPNSLVKELSIAQKQMVEIARVLSSET
                     KVLIMDEPTSSISKKETEILFRLINDLKESGVSIIYISHRMEELFEICDRITIMRDGK
                     TISTLNTKDVSSEEELVNLMIDRKLDQFFPKRKVEIKEEIMRVENLTKNNVFNDISFN
                     IRKGEILGIGGLVGSKRSEIVEAIFGLRTYDSGKIYLNNEEVKFKTPSDAIENGLGLI
                     TEDRKGTGLFLQMSVKENTTMAGLKKISKFKSIIDRKKEKEILEKYIEALKIKTPHMN
                     QVIQSLSGGNQQKAIIARWLLLQPDILIMDEPTRGIDVNAKAEIYNLMGDLVESGVSI
                     IMISSEIPELISMSDRIMVMREGHISGFLEGEEMVENNVLKLAFGGKINEFNN"
     gene            complement(8345..9307)
                     /locus_tag="KRO40_001905"
     CDS             complement(8345..9307)
                     /locus_tag="KRO40_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBH2092725.1"
                     /translation="MRVRKILSLGIAGILAIGMLTGCSMEGPSKSDNKGGSDKKDLTI
                     GVSTITLQHQFFIDIDEGIKEKAKELGVKVIVNDPDQDVAKQTSAIEDFIQQNVDGMI
                     VLGTDNSAIVPAVEGAFEKMPVVTVDAVLNTENITSYVGTVSYDAGKKLGEYTKKYID
                     EKLGGKSEIAIVTDLKSQIQMQRIDGFKDALKGSANVKILNSQPGYDREESLNTVENL
                     IQSNPDVDIIYATAENSVLGAKAALESAKNKDVKIVGFDLTEEASSGITDGTILAMIQ
                     QQPKEMGRLAVEAVVKAIKGEKVEKNIPVPALLYDKENIKDFKN"
     gene            complement(9355..10245)
                     /gene="rbsK"
                     /locus_tag="KRO40_001906"
     CDS             complement(9355..10245)
                     /gene="rbsK"
                     /locus_tag="KRO40_001906"
                     /EC_number="2.7.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribokinase"
                     /protein_id="HBH2092726.1"
                     /translation="MGNIVVIGSVNMDMVCSVDKRPEKGETVLGNSFFTSPGGKGANQ
                     AISASKLGANVKMISCIGEDGLGEELIRNFRTNKVDYSLVSRNNHKSSGVAVITLCEN
                     DNSIVVVPGTNELVDIELIKKNEEEIKNADIVLLQLEIPLKTINYVVNFCFENRIRVL
                     LNPAPAVKLNEDIIEKVTYLTPNEHEYKIVFDTNEGIEEVLKKYPNKLVITEGKNGAR
                     FYDGEEIKHVSCISVDVQDTTGAGDTFNGALAVAITEGKNLYTAVEYAVVVSGLSVTK
                     LGAQSGMPYKEDVEKYLNNK"
     gene            complement(10287..11300)
                     /locus_tag="KRO40_001907"
     CDS             complement(10287..11300)
                     /locus_tag="KRO40_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH2092727.1"
                     /translation="MSITIKEIGELAGVSKTTVSKVINNKDENISQATREKILKIMKE
                     KNYVPNKLAQSLVTKKTNTIGLLIPDIRNPFFTDVSRGVEDKANEEGYNIILCNTDED
                     AKKEYEGIRTLSERMIDGIIFAASSNTNWKEANYKDIKIPTVLIDKKISMNKETLKGI
                     VKINNFEGAYIATKHLLDIGNKKIIYLSGPLQNEIAVDRLEGYKKALIECNLSYNPAY
                     VFEGKYKIEWGQEFIKNLEKIDFDAIFCANDLIAIGVIRGLKERGLSIPNDISVVGFD
                     DIQTSSLISPSLTTVKQPSYDIGYKASEILINCLRGDKKESFDELIFKPELVIRDSTK
                     ESE"
     gene            complement(11529..12506)
                     /gene="bioB"
                     /locus_tag="KRO40_001908"
     CDS             complement(11529..12506)
                     /gene="bioB"
                     /locus_tag="KRO40_001908"
                     /EC_number="2.8.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin synthase BioB"
                     /protein_id="HBH2092728.1"
                     /translation="MEKYIIKLKNKVLREKEISYEEALNLISLDTNNKNDFDILLKSA
                     NEIREYFMGRKADLCTIMNAKSGKCSEDCKFCAQSSYYKTGVEEYSLLDYNEILNRAK
                     EMESKGVHRFSLVTSGKGMSGKEFNNILNIYEGLRENTNLKLCASLGIIDYEQAKMLK
                     SAGVTTYHHNVETCRDNFHNICTTHTYKDRIKTIKDAKKAGLDVCVGGIIGMNESEEQ
                     RLKMAFEIRELNVKSFPINILNPIKNTPMENYDVLEPMEILKTTAVFRFIIPNVYIRY
                     AGGRLSLKGYDKVGFNGGVNSAIVGDYLTTVGSGIENDKKMIIEQGFEF"
     gene            complement(12712..12975)
                     /locus_tag="KRO40_001909"
     CDS             complement(12712..12975)
                     /locus_tag="KRO40_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092729.1"
                     /translation="MKIYYEKENSKKANVNNIPSVFAFNFLRNFLTSKEYEETRKEYF
                     INNLTKSQVNQAMKDLKWLFREYEGLEVITMESLDGVKTRIVL"
     gene            complement(13045..14118)
                     /locus_tag="KRO40_001910"
     CDS             complement(13045..14118)
                     /locus_tag="KRO40_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBH2092730.1"
                     /translation="MEKSKVYFCDLYSNSQNKNVPNNVRRLFDEAGFKDLIEKNDQVA
                     IKLHFGEKGNTTYMSPVAVRQVVDKVKDCEGKPFLTDTNTLYTGSRTNSVDHLTTAIE
                     NGFAYAVVNAPVIIADGLYSRNYENVKIDKKHFESVKIGGEIYNSSAMIVMSHFKGHE
                     AAGFGGALKNLAMGCASAAGKQMQHSDVTPVVKEKKCVGCGKCVNSCPTKAISIVDKK
                     AVIDSDVCYGCGECPTVCPTRAVTIQWESDSDVFVEKMAEYAYGAVSNKKDKVGYITF
                     VMNVTPLCDCVPWSGRPIAHDIGILASTDPVAIEQACYDLICKEMGHDVFKHEHPHVN
                     GTRIIDYACEMGMGSKEYELIKL"
     gene            complement(14377..15135)
                     /locus_tag="KRO40_001911"
     CDS             complement(14377..15135)
                     /locus_tag="KRO40_001911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092731.1"
                     /translation="MREYIAFTKKEFKENLRNYKLFSLIILFLIFGISSPISAKFMPD
                     LIAHFAPTLKVTAAPTALDSWTQFFSNISGLGMSLTLIIFCNILSNEYSKGTLVIMLT
                     KGLSRSSIVLSKFSVTVIIMTIGFWLSFLFAYGYTMYFWPTANLNHIIFSAFNLWLIG
                     IMYISVLILGCVLFRPAFASVLLVLVATLLLSLISIPKQIAPYTPNFLMSKNIDLISG
                     KVAMPEFIIPIIITVLISIVCLLAAVILFNKKPV"
     gene            complement(15132..16049)
                     /locus_tag="KRO40_001912"
     CDS             complement(15132..16049)
                     /locus_tag="KRO40_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092732.1"
                     /translation="MNIVSINGLSKGFGNRKIIDNLNFTVPEGSVFGFVGKNGAGKTT
                     TMKMVLGLLKPDGGTIDVCGEKVTYGKTSSNRHVGYLPDVPEFYNYMRPLEYLSLCGE
                     ITGLSKKEIQIRSEELLSLVGLGNEKRRIGGFSRGMKQRLGIAQALLSRPKLLICDEP
                     TSALDPVGRKEILDIMLKIKDSTTVIFSTHILSDVERICDHVAILNKGSIALSGTLSE
                     IKSMHGKDRLLLEFASNDEIQKFKSSDGIKSLLKDSEETNMEIVLHGKDIKAIQKTVI
                     STLAEMNLCPVKMELIELSLENLFLEVVK"
     gene            complement(16049..16249)
                     /locus_tag="KRO40_001913"
     CDS             complement(16049..16249)
                     /locus_tag="KRO40_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLDc_N domain-containing protein"
                     /protein_id="HBH2092733.1"
                     /translation="MENLMEYLPLLVPVIILDLILIITALVHVLRHPNYKIGNKAIWI
                     IVVLFISLIGPILYFTIGRGEE"
     gene            complement(16254..17348)
                     /locus_tag="KRO40_001914"
     CDS             complement(16254..17348)
                     /locus_tag="KRO40_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092734.1"
                     /translation="MNELNIAKTLILKRKEKGITQDELANYIGVSKASVSKWETGQSY
                     PDITFLPQLATYFNITVDELICYEPQMMKEDINKLYNKLCKDFTVKPFDEVMDEIREI
                     IKKYYSCFPLIFRMGLLIVNHYDIVDEKKRELLISEALEIFIRIQETCNDIDICRQAK
                     SMEATCYILLNQPIQVIDLLQNSNFPMINESILLAQGQMMNGQMDEARETFQLGAYQN
                     LISLVQNLVGILQNADKLQMKEIERRILAISDIFELDTLSPAIMLSSYLTQAQINLIH
                     GDNEGAIKSLRKYVDLATRDIYPIIIHGDDFFNKLDRWISEIGTGITRDDTIVKAGIV
                     AAIKNNPMFSVLSENKEYKFLIEKLSLLEE"
     gene            complement(17858..17998)
                     /locus_tag="KRO40_001915"
     CDS             complement(17858..17998)
                     /locus_tag="KRO40_001915"
                     /inference="COORDINATES: protein motif:HMM:NF021468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2185 domain-containing protein"
                     /protein_id="HBH2092735.1"
                     /translation="MNGEGCILSNKITKECYKVGYMIREKSIDIYPDSGWGFMTWDEN
                     GE"
     gene            complement(18308..19615)
                     /locus_tag="KRO40_001916"
     CDS             complement(18308..19615)
                     /locus_tag="KRO40_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2092736.1"
                     /translation="MDISRSVDNSLNRTIEFLKELIKIDSQQGEPISQCPFGIGPKKS
                     LDKTLDYCASLGFSVKNIDNYIGYAEIGEGEELIGIPMHLDIVPPGEGWSVDPFSGAV
                     IDNIIYGRGVIDNKGAVSMLIHVLKNIEDMYPTINKRIRLIFGTNEETGMKCIKYYLD
                     KGEEIPSMGFTPDAMYPVVNGEKGRVHIRIEKEIKIDKSKPYIIVSGGTKENVVPSHC
                     TAKIINGIISELTTKGVAVHASNPEKGENAISKMVIKIVEDNMDFQHREDIELVSKYL
                     CSDYYGDALGINQYDEVFKNTTLNLGILKVNEEKIVCELDIRYGKNIVLNNIIDRFKK
                     VFCNGWKIEVIAHKDLHYVDESNLVLKKLLEAYEEVTDENGYTIAMGGGTYASWFKDM
                     VAFGPKFLAYKTGGHGVDERVPINHIRKNMEIYTLALIKLLEL"
     gene            complement(19680..20159)
                     /locus_tag="KRO40_001917"
     CDS             complement(19680..20159)
                     /locus_tag="KRO40_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-2-amino-thiazoline-4-carboxylic acid
                     hydrolase"
                     /protein_id="HBH2092737.1"
                     /translation="MSEKMYTEKEYLEGIRGATGERAVWFYLLMKEAEKLGANPDDIC
                     KEAIYGFGKMRGQKYNVADTPGKMAEMLYNSKGQKVFEMELVENTDENGVLKFHHCPL
                     DAAWKEYGLTKEERKEICRLACYGDYGRVDCAQGVKLDFAQKCAHDDEVCELVFTKK"
     gene            complement(20206..21069)
                     /locus_tag="KRO40_001918"
     CDS             complement(20206..21069)
                     /locus_tag="KRO40_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBH2092738.1"
                     /translation="MQEIKNKEVKNGQGPTEVNKTRVLTKKDVTKTYLRWWWTAELSN
                     SFERMQALAVCASFTPALEKLYKRKEDLVDALKRHLQFFNTQAIWGGLIHGTVLAMEE
                     EKATEGKIPGEVISGVKNGLMGPLAGIGDTLDFGTFQTIFLALGASFGAEGSVIGAFF
                     PIMFSILLFCEGYYLFHLGYSLGRDSIKKILSGGIVNKIIDGASILGMFMMGALSATT
                     VKLSTPLSFDIGGKAIVVQDTLNMIAPGLLPLGVVFFVYWGMKYKKWTITKLLVILVV
                     LALVGSFIGIF"
     gene            complement(21069..21824)
                     /locus_tag="KRO40_001919"
     CDS             complement(21069..21824)
                     /locus_tag="KRO40_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2092739.1"
                     /translation="MESVLMLAIVTGLWYWFAAGLAGYTLFSTLKSPLFIGFSLGLLW
                     GDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIAIPVALQTGVNAEVAVSIAVP
                     LGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVC
                     NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMV
                     QYFEISITAAAIFGVCIALLITFMKEDKRVGEV"
     gene            complement(21851..22339)
                     /locus_tag="KRO40_001920"
     CDS             complement(21851..22339)
                     /locus_tag="KRO40_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092740.1"
                     /translation="MAKITLVRVDHRLIHGQVITKWVKIAQAQKIIIVDDFLGQDEFM
                     ADIYKMAAPSGVEVVILTAEDAGQAFQNNTLGDKNIFILFKNVDMANKAYKAGLKYEK
                     IQLGGIPNEAGKKMVFTAVSLGNEDVEQLNELNENGVEIVLQVIPEESSMTYENALKK
                     FK"
     gene            complement(22357..22758)
                     /locus_tag="KRO40_001921"
     CDS             complement(22357..22758)
                     /locus_tag="KRO40_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIC"
                     /protein_id="HBH2092741.1"
                     /translation="MNKYKVIILCHGTWGKVLVEETNKNFGLSNQYEVLSLSSEKDVS
                     VFMKEVEEVVDKEDVKIIISDLYGGSTSSVAIAVAIRRGIDAINGLSLQTILIVDEEL
                     SKEDKLHTLPERIVKKNNNLCVDLIKEFKKI"
     gene            complement(22761..23258)
                     /locus_tag="KRO40_001922"
     CDS             complement(22761..23258)
                     /locus_tag="KRO40_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2092742.1"
                     /translation="MSLVKYCRCDDRLIHGQVIYKWVKHLGVKKIVVVDDETTNDVIA
                     KGLIKMAAPKNIDLSILTVSESRRYFYNNQADDNVFVLIKNLDTANRMIEEGINIKKL
                     IVGRIPTGIGKKKISQNVYINKKEFLLIDEFIKKNINVSIQMVPDEEEVELNQNINRY
                     KGEFI"
     gene            complement(23282..23686)
                     /locus_tag="KRO40_001923"
     CDS             complement(23282..23686)
                     /locus_tag="KRO40_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092743.1"
                     /translation="MIGIIVMTHGSFSEEIIKSCELIAGPAERTAAIKLNRNDNIEDL
                     NKNFVEKLNELDEGDGVLVLADLLGGSPSNVASLNLKKGGKFHALTGVNLPMLLEALI
                     NREGKSLEELAEACIEAGQTGINNINKVLSSM"
     gene            complement(23916..26483)
                     /locus_tag="KRO40_001924"
     CDS             complement(23916..26483)
                     /locus_tag="KRO40_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092744.1"
                     /translation="MTQKKLSRKEKVLICLKRLTEEHLNFNNGIRFGFDAEYIATEVG
                     INRSNASKELNQLIKESIIIKIKGKPVQYLYKESIESILGKKLNKGIFDNINSINEYS
                     ENDSIKDEYILESIKKENNIFNLVGCDGSLRSQIEQAKAAVIYPPKGLSTLIIGPTGV
                     GKSIFAEYMYKYSLTIKEDSDNAPFIIFNCADYSDNQQLLLAQLFGYVKGAFTGADKD
                     KYGIVHEANNGVLFLDEVHRLSAEGQEMLFLLMDKGIYRRLGEANKVHECRVMIIAAT
                     TEDPETAMLETFLRRIPVTIKIPSLEERGFQERMKLICYFFKEESVRIGVKLKVSKEV
                     IKAFILYKCKGNIGQLKSDIQLICARAFLDYMTYKRECVYVRLSLLPNNIRESLYGNN
                     RKEEFVQNFSFIGKDDIIFLPEEKDFESENLLIENKKYDLDFYGMIKETWNKLQQEGI
                     KESQIRSVIDGDIQKYSYNLMNTFIYNSSNQTAYNNIVNDSIATTVKYILQKHDKWSK
                     REGLDKLIKAIALHIQNLIERIKIGNIVKHPNKDEIMKERAYEYNIAKEILSNMSLMY
                     GVEFPEDEAIFLATFLYLSYVGLNEESIAILVIMHGESTASSMVNVANTLLDCNHAVA
                     INMGLEDRVQDILVQAVEIANKIDKGKGILILTDMGSILTFAKVIRDATGKEVKAIDM
                     VSTPIVIEATRKALTPEMTLEKLYFNIIESIKKHYGDMEVTYAEKDNGGRYFDRLLID
                     NISKTLTFLNGEKAYFILKEVINRISEHYSLVIQDELLVKFIFHCSCMIERVIIKESL
                     VYKSYEERISRNKELYLVIKESFKLVEETFDIIISDMEYANILDIFESQYDTDKFKS"
     gene            26649..27392
                     /locus_tag="KRO40_001925"
     CDS             26649..27392
                     /locus_tag="KRO40_001925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBH2092745.1"
                     /translation="MNFLSDLHTHSIVSGHGYSTLLENINYCKENGIKILGTSEHGPK
                     MPGSPHKWYFHNIQNIPRIINNIIILRGCEANILDIKGNIDLEPFVIPRLDYLILSFH
                     EAVFSPNTLENNTKALINAINKHDNIEILGHLGNSNYPIDYELIIKLAIEKNILIEIN
                     NCSIKGVSRNGSSDNCKYIATLCKKYGAKIILTSDAHICFDIGNYEYSENILKEINFP
                     DELIMNYPKKLINHFHQKGKLLDVDYTNI"
BASE COUNT         8655 a         5183 c         2781 g        10800 t
ORIGIN      
        1 ctacaatttc attaaaatta aatataaaaa tcaactatta ttttttaaat agcatctttc
       61 ttaatctatt attgtaataa cctataaaag aactgtaaac atagtcatat actataaagg
      121 ctatctcaaa tgaacctata ataaatatgt ttattggaat ataaactatt gttcttaata
      181 aaaaatacaa tataagtatc attatatttg caaatactaa tttcataaaa tactcaatat
      241 atatagacct atctttttct ataagatatt ttacaatacc atatattcca aaggtaagtg
      301 aatatacaat ccattgagac ttacttgcca tcactataaa tcctaaaact atagaaccta
      361 tataaaaagc aattccactc ttaaagcccc attccattat tacaattgat actaaaagtg
      421 atgctaaccc cataataaac aatgtattta caggaataat gtttgtaaga gtcaacaata
      481 tcacatttaa tgctaataaa actcctccat aagcaacttt tatactcata tttatcatcc
      541 taacaacaag ttattaaatc tccaccaaaa cattcacaac atgaatctaa acaccaaagt
      601 ttagcacaat tttcacaaca atcgtcacct agacaacaac agcaatcatc acagcaacag
      661 caacaacatc catctaaatc attacgtctt cttctattat aattgtcagc cctattgcta
      721 taatcatttc tatattgtgt ataacttcta agtgcatcac tatattcact attttcaggc
      781 tccataaatt ttgctctttt taagaagtct tcaccttctt cataatatcc tatgttcatt
      841 gcagaaaaac cagttaaata ataccactct gcacatttgt cagtcaaagt ttttaaaaaa
      901 tcatatgctt ttttaaattc actattttct atgaatgatc ttgctctcat aaaattttca
      961 ttattataag tattactgta cattctttcc acctctactt tctaatatat taatatatct
     1021 taaataaaca ccagaataaa ttatattttc tattattcca acatttttat ttagatttag
     1081 attatcaatt cccctagcta aaaatcctaa tgatgttact attatttttt ttactttttc
     1141 ttttaactca tcatttttat caatatactc tataaatgga ttatatcttc ctttcttaaa
     1201 atcttcatct aaatcttcat aggcatctag tagatatata tacttaccta tattaaaacc
     1261 tatcattctt aagtttctct cattttcatc ttttttatag acaaatactt cacccattat
     1321 atttccaaat atactagata cttcatctat atttatattt ttatcttttt ctaacttatt
     1381 taattcattt agttgttgtt ttatatactc tgctttttca ggatactttt catatgctaa
     1441 ttttaatttg tttttatata tataatatgc caatttatct tttatgcgtt tatcatccat
     1501 taaattatct tccaatttat aatacgttaa aagaatattc atacttgctg catattctgt
     1561 aatatcattt gtaattacct ttttcttttt aaatggattt actatacaca cttcctctgt
     1621 acttatagac tctgggttat atactgctgt taataaaaca attaaaaatg ttatatcata
     1681 gttcaaagaa aacctagaga tttctccatg atttcttttt aagtatttac atagtccaca
     1741 atagtaagct ttgtaataat catattctct aaatgttaaa tccattttgt ttattttaac
     1801 atatccaaac ataaatactc ctttttgtac tattttttat ttagattata tatagtataa
     1861 cactttttat caagattata taatttacag tattctaaga aacttaaaaa attccttcta
     1921 atcattgtat cttaaattta aaataattag aaggttgggt taaaaataat attaaattat
     1981 atacttatat taactcatac aagttagtta tgcttatatc aatttaagtt ttaaataatt
     2041 ggtatatatt taaaactacc tacagtatcc ttcaattctt tttttgcttt gtttataacc
     2101 aattcatcaa gcattacatc atttattgaa catgatatag atttagatgc caataacatt
     2161 gctttaaatc ccatatcaga acctgcactg gcacaagatt gccatgtatg ggcagaaata
     2221 ccaataggcc aaactgaaca agaacactgt gctgtaggaa ttatgtagct aacatctcca
     2281 atatctaatg ataatgatat acagttatta tgagtaaatg tatcatccgt aacttcatca
     2341 tgcagattca tcttagtaat atccttattt ccacttaata cactagaaac actacttctt
     2401 ttatctatag acactgtctc agctaattta tctgcaaaat agtagtcatc ttcattatag
     2461 ttttgcacac ctactaattt catattttgt gatagaatat ctgttaatat tgtatttgga
     2521 atatagtcat atactccact tataatgtca tattccataa tagtaccagt cattaatgct
     2581 gctccttttg ctatatcaac aatcctacca aatacatctc ttacatgctc cattttaact
     2641 cctcttatgt aataccacac ttctgcaaaa tcaggaacta tatttggcat ttttccacca
     2701 ttagtagtta catagtgtac tctacaatta tcaaatatat gttctctcaa ataattacaa
     2761 cctatattca taagttctac tgcatcaagt gcacttcttc cgttataagg agcttgtgct
     2821 gcatgggcac taatcccatt atatctaaat ttcacagagt aattagcaag tgttggtatt
     2881 cttattggag tatttatatc aaatggatgc caactaaaag cacaatcaat tccatcaaaa
     2941 aaaccttttt ttatcatcaa tacttttcca gataaatctt cttctgctgg acatccatag
     3001 tattttatag tccctttcag cttttttagt ttgattaatt cctttactgc aattacagct
     3061 cctattgaac ctgtaccaag taagttatgt ccacatccat gacctgcacc accatctaca
     3121 ataggttctt tagtagtgga tactttttga gacaaaccat ctaaagcatc atattctccc
     3181 aaaactgcta taactggtct accttctcca taactagcca caaatgctgt atccatacct
     3241 tctaatccct ctatactaaa accatgtttt tttaaacatt ctttttgtaa atttgaagca
     3301 tagtattctt tatactgaag ttctggattt ttccatatct tatctgatat atctcttaat
     3361 tctccctgta tctcatctat atattccatc aaaaactttt tatttaaatt atccatatta
     3421 attatataaa cctccctgtt tctaataact tatcgattat cagccaaaat gactaatttt
     3481 aactgattta aaaatatttt ctaccataca accattttat acaataaaac ctcttgactt
     3541 gtaagtttca ttttatcaag taagaggttt tcaagtttta taaaattttt agcatgttaa
     3601 ccaatcaagc atattaaccc ataatttatt atagtatttc caatcagtaa attcttttgg
     3661 accccagtga ggtgcacagt cagaactaaa gatagcagat tttccttttc caaactcgcc
     3721 aacagctaca aatgggtctc ctccaatagt tgctaaaaca ggacaattat ctctagctac
     3781 tgttttgtta tatcctaaaa actttggcca ttctgttggt atacctttta atactggatg
     3841 ttcagagtca ataacttctg gaattattcc tgctggtttt tcaactctat catctttatc
     3901 tatcattgtt attggtaata catctttgat agcagtttct ccaaatctag cttttgcatc
     3961 tattcctgta aatgacatat atccacctac catgattaac gccccaccat tatttacata
     4021 ctctttgatt agttcaagtc tatctggatt actattgcaa tctataaaag tactattaga
     4081 taataagaac gtattagaac ctatatcaga taatattata cagtcatact catttaactc
     4141 ttctaattta tacggaaaac tatctgctgc tacatgtgca ggcatatgaa ctgtctcata
     4201 tcctccagat tctattgctt ctttcaacca ctttacagct tcttcataat gagttgtaac
     4261 aaacgtatca aaccctttta tatgagttat attttttacc caagattccc ctactattaa
     4321 tacttttttc atttatatat tcctcctact tttataagtt taatattaga cttgcataca
     4381 taagtatact atctaaatac tccttaattt caacatattc atcaattgaa tgacattgtt
     4441 ctattgaacc tggccctaat ataagtgttg gtatttcagc taaatttttc attactctcg
     4501 catcattgcc agctgttgaa ccttttatct ctaatttttt tcctagagtt tcttctagta
     4561 ttttatgtgc attcactaca aaatcagaat ccttgtccat ctcaaaacct aaccctgatt
     4621 gatatatgtt tatatttggt ttattatctt taagccataa atctccatta gcccttgtca
     4681 ttatgacatt tgttacatca tttacaactt gttcataact cattatattt ggcaagaagt
     4741 gtacacataa attaaataca cacttatctg gcacagtaga acctgctgtt ccaccattta
     4801 ttacacctaa atttattgta ggtgaaggta atagtggatg tttatatatc ataagccagt
     4861 tatgttccaa ctcttttata tcttgaagca acaacatagc cttctcaatt gcatttacac
     4921 cctcccactt actaccacag tgaagagaca cacctttaac ctcaacttca aagaatacaa
     4981 atcccatatg tgcaactatt aagttttgtt ctgatggttc acaaattatg caacaatctc
     5041 catcaatacc attcataact gcatttatgg taccatttcc gccaccttct tcatctacta
     5101 ctgacattat ttttacatta ccaggtacat ttagaccact atcttttata agctttacag
     5161 ctaatattga tgctataagt ccagatttca tatcagcagt tccaagacca taaagttttc
     5221 cattatcttc tgtagcacga tatggattat atttccactt acttatatca cccggtggca
     5281 tagtgtctac atgaccatta aatacaattg tcttaccagg taaatcatca ctatacttac
     5341 aaattaaatt atatctatct tgataattgt gacctagatt tccttcttta tatatatttt
     5401 ttgctttttt aattaattct tcgctcattt cttgtctatc cacactaaaa cctatgtaat
     5461 ttgcaagttt ttcaatatat tcctgtcctt ctttttcaaa tccacctagt attccatgac
     5521 caacatcttc agtctttata cttacaagtt cttttaaata atctatgtat tcttgttttt
     5581 tactatttaa tgtatctaag agaatttttt tcatatttcc tcctaagatt tatttttaca
     5641 tttaaaattt caagtctaat ctcatctatt taagccatag taaacttttt cacttagcat
     5701 attctcattc aatgtataaa gatgtatgca aattaaagta taaaaatata tacaaaaact
     5761 taataatttt tatagtttat aagctaaaat ttaattacta tttagattta gctgattttt
     5821 ttaattttat attatttatc catatagcaa ataacattac caaacctttt ataatcattt
     5881 gattatatga agatacactt aataagttta atccatttcc taatattcct attattccga
     5941 cacctataca tgtacctact atagaaccag aaccacccat catattagta ccaccaagca
     6001 caacggctgc tatagcatcc aattctgctc catctccaac agttggtgaa cctgatgcca
     6061 aacgtgatga tagtattatc ccagctaatg ctgttagtag tccagctagt gcgtatactt
     6121 ttactataac tttatttact tttactccac ataatctagc ggcctcttca tttccaccta
     6181 ctgcatgtac atgacgtcca aaattagttc tttttaatag aaaatgtcct gctattacaa
     6241 ctataatcat aattataact ggtattggta ttggtccaat atatcctcta ccgagcatct
     6301 taaatgcatc tgtatttact gatataggtc ttcctcctgt aaatacaaag cttgccccac
     6361 ttattatcgt taacatggct aaagttacaa tgaatggagg tagtttttgt gttgaaataa
     6421 ttgcaccttt tatgactcct aatattgtcc ctattgctaa tgcaagtatc atacctaccc
     6481 atataggtgc attataattc actactgttg tagcccaaaa tgtacctact aaagcaatta
     6541 ctgctcctac acttaaatct attcctcctg taattattac aaatgtcata cctactgcaa
     6601 gtattgcatt tattgatatt tgtcttccaa cattaattaa attatctaaa gttaaaaagt
     6661 tagatgaagc tacactcatt attataaaaa ttattacaag tcctacagct gcactccctt
     6721 ggtctctaaa tacacttgtt aattttgtca ataatggaga agatttttct tctttatgct
     6781 tagttattga actcattaat tttacctccg aaagccaatt ttaatacatt attttcaacc
     6841 atttcttcac cttctaaaaa tccacttata tgaccttctc tcataaccat tattctgtca
     6901 ctcattgata ttaattctgg tatttcagaa gatatcatta ttatacttac accactctcc
     6961 actaaatctc ccattagatt gtatatctct gccttagcat ttacatctat acctctggtt
     7021 ggttcatcca taatcaatat atctggttgt aataaaagcc atcttgctat tatagctttt
     7081 tgttggtttc caccacttaa actttgtata acttgattca tatgtggtgt ttttatcttt
     7141 aaagcttcta tgtatttttc taaaatctct ttttcctttt ttctatctat aattgattta
     7201 aacttagata tcttttttaa cccagccata gttgtatttt ctttgacact catttgtaaa
     7261 aacaatccag taccttttct atcttctgtt attaatccta gtccattttc tattgcatct
     7321 gatggagttt taaactttac ttcttcattg tttaaatata tttttccaga atcatatgtt
     7381 ctaagtccaa atatagcttc tactatttca cttctcttac ttccaactag tccacctatt
     7441 cccaatattt caccttttct tatattaaag ctaatatcat taaaaacatt gttcttagtt
     7501 agattttcca ctcgcataat ttcttctttt atttctactt ttctttttgg gaaaaattgg
     7561 tctagctttc tatctatcat taaattaact aattcttcct cagacgatac atctttggta
     7621 tttaaagtcg aaatcgtttt cccatctcgc attatagtta ttctgtcaca aatctcaaag
     7681 agttcttcca tcctatggga tatatatatt atactaactc cactctcttt taaatcattt
     7741 ataagtctaa aaagtatttc agtctctttt ttacttattg aagaagtagg ttcatccatt
     7801 attaatactt tagtttctga tgataaaact cttgctattt ctaccatttg tttttgagct
     7861 atactaagct ctttgactaa actatttgga tttatatcta ttcccatatt atcgaaaatc
     7921 tttttagcct cttcattcat ttttttgtca ttggttaaga ctttgccatt tatttctttt
     7981 cccataaaaa tattttgtgc tactgttaat tcgtcaaaaa ctgttagttc ttgatatatg
     8041 gcatttatac ctatcttttt agagatatct ggggatatat tctctatttc tttgccttca
     8101 aaaataaatt ttccagaagt tttcgaatgt gcaccagtta aaatctttat cattgttgat
     8161 ttaccagcac cattttcacc cagtagtgca tgaacttcgc catgaaataa ctcaaaatta
     8221 acattatcta atgctctgac accaggaaat tctttagcaa tattacttaa cttcagaatt
     8281 atattactca taatgacact cctttttaaa taggatttct ttcaaataat ctcattttat
     8341 tttactaatt cttaaagtct tttatatttt ccttatcata aagtaaagct ggtactggta
     8401 tattcttttc taccttttcc ccttttatag cttttactac tgcttctaca gctaaacgtc
     8461 ccatctcttt aggttgttgt tgaatcatag caagaatagt tccatctgtt attccacttg
     8521 atgcttcttc agttaagtca aatcctacaa tcttaacatc cttatttttt gcagattcaa
     8581 gtgcagcttt agctcctagt acactatttt cagctgttgc atatattata tctacatctg
     8641 gattagattg aattaagttt tctactgtat taagagattc ttctctgtca tatcctggtt
     8701 gtgaatttaa tatcttaaca tttgctgaac cttttaatgc atctttaaat ccatctattc
     8761 tctgcatttg tatttgagat tttaaatctg tcactattgc tatttctgac tttccaccta
     8821 acttttcatc tatgtatttt ttagtgtatt cccctaattt tttaccagca tcataactaa
     8881 ctgttcctac ataacttgta atattttcag tatttaatac agcatctact gtaactactg
     8941 gcattttttc aaatgctcct tctactgctg gtactatagc cgaattatca gttccaagta
     9001 ctatcattcc atctacattt tgttgtataa aatcttctat tgctgatgtt tgcttagcta
     9061 catcttggtc tgggtcattt actataactt tcacacctaa ttctttagct ttttctttta
     9121 ttccctcatc aatatctata aaaaattgat gttgaagagt tattgtagat actccaatag
     9181 ttaaatcttt cttgtctgaa ccacctttat tatctgattt acttggtcct tccattgaac
     9241 accctgttaa cattcctatt gctagtattc cagcaattcc taaagataaa atttttctca
     9301 ctctcataat taacctccat ttttaatagt tttaaatttg aacaaattag atttttattt
     9361 attatttaaa tacttttcaa catcttcttt atagggcata ccagattgtg cacctagttt
     9421 agttacagaa agacctgata ctactactgc atattctact gctgtatata aatttttccc
     9481 ttctgttata gccactgcca atgctccatt aaatgtatct cctgctcctg tggtatcttg
     9541 aacatcaaca cttatacaag atacatgctt gatttcctca ccatcataaa atctagctcc
     9601 attttttcct tctgttatta caagtttatt tggatatttt tttaatactt cttctatccc
     9661 ttcatttgtg tcaaaaacta tcttatattc atgttcattt ggtgttaagt aagttacttt
     9721 ttctattata tcttcattta gttttactgc tggtgctgga tttaataaaa ccctaatcct
     9781 attttcaaaa cagaaattca ctacataatt tattgttttt aatggaatct ctaattgtag
     9841 caatactata tctgcattct ttatctcttc ttcattcttt ttaattaatt ctatatctac
     9901 tagctcatta gtccctggta caacaacaat actattatca ttttcacata atgttataac
     9961 agcaacacca gaacttttgt gattatttct ggatactaag ctataatcaa ctttattcgt
    10021 tctaaaattt cttattaact cctctcctaa gccatcttcc cctatgcatg atatcatttt
    10081 tacatttgct cctagtttag aagctgagat agcttgatta gccccttttc ctccaggtga
    10141 tgtaaaaaaa ctattaccta atactgtttc tcctttttct ggtcttttat ctacagaaca
    10201 taccatgtcc atgtttacac ttcctatgac aactatgttt cccattacat tactccttta
    10261 catatctatt tatgtctctc gtgctgttat tcactttctt ttgttgaatc tcttatgacc
    10321 aattctggtt tgaaaatcaa ttcatcaaac gattcttttt tatctcctct taaacaattt
    10381 atcaatattt cactggcttt atatcctata tcataagacg gctgttttac tgtggtaaga
    10441 gaagggctta ttagacttga tgtttgaata tcatcaaatc ccacgacact tatatcattt
    10501 ggtatactta atcctctttc tttaagacct cttatgacac ctattgcaat caaatcattt
    10561 gcacaaaata ttgcatcaaa atctatcttt tctaaatttt ttataaattc ttgtccccat
    10621 tcaatcttat attttccttc aaatacataa gcaggattgt agcttaaatt gcactcgatt
    10681 agagcctttt tatatccttc taatctatct actgctattt cattttgaag tggaccactt
    10741 aggtatatta ttttcttatt tccaatatct aataaatgtt ttgtagctat ataggcccct
    10801 tcaaagttat ttattttaac aattcctttt aaggtttctt tgttcatact tatcttctta
    10861 tcaatcaaga cagttggtat ttttatatct ttataatttg cttctttcca gtttgtattt
    10921 gaagatgctg caaatataat tccatctatc atcctctctg atagtgttct tattccttca
    10981 tattcttttt tagcatcttc atctgtatta cataaaatta tattgtagcc ttcttcatta
    11041 gctttatctt ctacacctct tgatacatct gtaaagaatg gatttcgtat atctggtata
    11101 agaagcccta tagtattagt ttttttagtt actaaacttt gtgctaattt atttggtaca
    11161 taattttttt ccttcattat tttcaaaatt ttttctcttg ttgcctgact tatattttca
    11221 tctttattat taatgacttt tgacacagtt gttttagaaa caccagccaa ttcgccaatt
    11281 tcttttatag ttatactcaa gaagttcacc cccaaaattt aggaaaccgt tttacttaac
    11341 cggttaccta gatactatca catctttttt tcatttgcaa ccattttata taaattttga
    11401 tatttttccc ttttttcaaa atattgcaac ttataattca attttaatat ttaaattaat
    11461 ctgcaaaaaa aaattaatat acttttataa ttatctaaaa gtatattaat taatttaagc
    11521 agtatttatt aaaattcaaa tccttgctct ataatcattt ttttatcatt ttcaatccca
    11581 cttccaacag ttgtcaaata atcaccaaca attgcagaat ttactccccc attaaatcca
    11641 actttgtcat atccctttaa tgatagcctt ccaccagcat accttatgta cacattagga
    11701 attataaacc taaatactgc tgttgttttt agtatttcca ttggttctaa tacatcataa
    11761 ttttccattg gtgtattctt aataggattt aaaatgttta ttggaaatga ttttacattt
    11821 aattctcgta tttcaaaagc catttttagt ctctgttctt cactctcatt cattccaatt
    11881 ataccgccta cacatacatc tagcccagct tttttagcat cttttatagt ttttatccta
    11941 tctttatatg tgtgtgttgt acatatatta tgaaaattat ctctacacgt ctcaacattg
    12001 tggtgatatg tagtcacacc tgctgacttc aacattttag cttgctcata atctataata
    12061 cctaaagatg cacataattt taaattagta ttttccctca atccttcata gatatttaaa
    12121 atattattaa actcctttcc tgacatacct ttaccacttg taaccaatga gaatctatgc
    12181 actcctttac tctccatctc tttagctcta tttaagattt cattgtaatc taataatgaa
    12241 tattcttcta caccagtttt ataataagaa gactgagcac aaaatttaca gtcttcacta
    12301 catttgccag atttagcatt cattatcgta cataaatctg cttttcttcc cataaaatat
    12361 tctcttattt catttgcaga ttttaataga atatcaaaat cgtttttatt atttgtatca
    12421 aggcttatta aattaagagc ttcttcataa cttatttctt tttctctcaa tactttattt
    12481 tttaatttta ttatgtattt ttccatatat cctcctattt gtcaacttaa tatttttatg
    12541 tagtttactt attatatata gtattgcata tataacattt attggtcaac tttattttag
    12601 acacaagttt actatacaca aaaaaatact gcttcaaaac aatattagta tatagattat
    12661 acatattatt attaaagcag tattttttat tagaatataa ttcttactgg tttataaaac
    12721 tatccttgtc ttaactccat ccaagctttc cattgtaata acttctaagc cttcatattc
    12781 tctaaatagc cattttaaat ccttcatggc ttgattaacc tgactttttg ttagattatt
    12841 tataaaatat tcttttctag tttcctcata ctctttgcta gtcaaaaagt ttcttagaaa
    12901 attaaacgca aatacacttg gaatattgtt tacattagcc ttcttgctgt tttccttctc
    12961 atagtaaatt ttcataaatg catactcctt tgatactttt agatttctct tacaataatt
    13021 atatgcattt aagtgctact attcttataa ttttattaat tcatattctt tacttcccat
    13081 acccatttca catgcatagt ctattattct agttccattt acatgaggat gttcatgttt
    13141 gaaaacatca tgacccattt ccttacaaat caaatcatag catgcttgtt caatagctac
    13201 agggtctgtt gatgctaata ttcctatatc atgggcaatt ggtctacctg accaaggtac
    13261 acaatcacaa agtggagtta cattcataac aaaagttata taccctacct tgtctttttt
    13321 atttgatact gctccataag cgtattctgc catcttttcg acaaacacat ctgagtcact
    13381 ttcccattgt atagttactg ctctagttgg acagacagtt ggacattctc cacatccata
    13441 acatacatca gaatctataa ctgctttttt atccactata cttatagctt ttgtaggaca
    13501 agaattaaca cactttccac aacctacaca cttcttttcc tttactactg gagtaacatc
    13561 agaatgttgc atttgttttc ctgctgcact tgcacatccc atagctaagt tttttaatgc
    13621 tcctccaaaa cctgctgctt catgaccttt aaaatgactc attactatca ttgcagaaga
    13681 attataaatt tctccaccta tttttacact ttcaaaatgt tttttgtcta tttttacatt
    13741 ctcataattt ctactatata atccatctgc aattattact ggtgcattta caactgcata
    13801 agcaaatcca ttttctatag cagttgtaag atggtctaca gaatttgttc tactccctgt
    13861 atacagtgta tttgtatctg ttaaaaatgg ctttccttcg cagtctttaa ccttatcaac
    13921 cacttgtcta actgccacag gactcatata tgtagtattt cccttttctc caaagtgaag
    13981 tttaattgcg acttggtcat ttttttctat taaatctttg aatcctgctt catcaaataa
    14041 tcttcttaca ttgtttggta cgtttttatt ttgcgaattt gagtataaat cacaaaaata
    14101 tacttttgac ttttccatat ctacacccct ttaaaatatt tacttatact aattttatca
    14161 cttttaaagt aatttttagt atattttaac ataattaaat attcttatat ttatttgata
    14221 caaataatat tatttgtatt attttctaca cttaattcta tatattaaac tacacctaaa
    14281 aatcaaaaag acttgaaact taagtccaag tctttttgat ttttaggtgt agtttttaac
    14341 aacataagat tactttacct tgtgataaag gtattattaa actggttttt tattaaataa
    14401 aataacagct gctagtaaac atactataga aataagaact gttataataa ttggaataat
    14461 aaattctggc attgccactt tccctgaaat caagtctata ttttttgaca tcaagaaatt
    14521 aggagtataa ggtgcaatct gtttaggaat agaaattaaa ctcaataaga gagttgctac
    14581 caatacaagt aaaacactgg caaatgctgg tctaaatagt acacacccaa gaattaatac
    14641 actaatatac ataattccta taagccataa attaaatgct gaaaatataa tatgattaag
    14701 atttgcagtt ggccaaaaat acattgtata gccataagca aataaaaaac tcaaccaaaa
    14761 accaattgtc ataataatca ccgtaacaga gaatttagac aatactatag atgaacgtga
    14821 taaaccttta gtcagcataa taacaagtgt ccctttagaa tattcatttg ataaaatatt
    14881 acaaaaaata attagagtta aactcatacc aagaccagag atattgctaa aaaattgtgt
    14941 ccaagaatct aaagcagttg gtgcagcagt aacttttaaa gtcggtgcaa aatgagcaat
    15001 caagtctggc ataaattttg cagaaatagg actacttata ccaaatatta gaaataaaat
    15061 aattaaacta aataatttat aatttcttaa attctcttta aattcttttt ttgtaaatgc
    15121 tatgtattct ctcactttac tacctccaaa aataaatttt caagtgataa ttctattagt
    15181 tccatcttta ctggacaaag attcatttct gcgagtgtag atataactgt tttttgtatt
    15241 gcttttatat ctttaccatg caaaacaatt tccatattag tttcttctga atcttttagt
    15301 aaggatttaa taccatcact agacttaaac ttttgaattt catcattact tgcaaactcc
    15361 agtaaaagtc tatcctttcc gtgcatactt tttatttctg aaagtgtacc actaagggca
    15421 atgcttcctt tgtttaatat agcaacatgg tcacagattc tttcaacatc tgatagtata
    15481 tgtgttgaaa atattacagt tgttgagtct ttgattttaa gcataatatc taatatttct
    15541 tttcgaccaa cagggtcaag tgcacttgtt ggttcatcac aaataagtaa tttggggcgt
    15601 gaaagcaaag cttgagctat accaagtcgt tgcttcattc cacgagaaaa cccacctatt
    15661 cgtctctttt catttccaag acccacaagt gataacaact cttcactcct tatctgtatt
    15721 tctttttttg aaagtcccgt aatttcacca caaagagaaa gatattcaag tggtctcata
    15781 tagttgtaaa actctggaac atcaggcaga taacctacat gacgattaga acttgttttc
    15841 ccataggtca ctttctcacc acaaacatct atagttccac catctggttt aagtaaccca
    15901 agtaccattt tcattgttgt agtcttacct gcaccattct tacctacaaa cccaaagact
    15961 gacccttctg gtacagtaaa atttaaatta tctattatct ttcgattacc aaaacctttt
    16021 gataatccat ttattgagac aatattcatc attcttcacc tcttcctatt gtaaaataca
    16081 aaattggtcc tattagacta ataaacagta ctacaataat ccatattgcc ttatttccaa
    16141 ttttataatt tggatgtctc aatacatgaa caagtgcagt aattataagt attaaatcta
    16201 aaataataac aggaaccaaa agtggtaagt attccatcaa attttccata ctcttattcc
    16261 tccaataaag ataatttttc tataagaaat ttgtattctt tgttttcact taatacagaa
    16321 aacattggat tatttttaat agcagcaaca atacctgctt ttacgattgt atcatcacgt
    16381 gtaatacctg ttccaatttc agaaatccat ctgtcaagtt tattaaaaaa gtcatcccca
    16441 tgtattataa ttgggtatat atcacgtgtt gctaaatcta catattttcg taatgattta
    16501 atagctcctt cattatcacc atgtattaaa ttaatttgtg cctgtgttaa atatgaagaa
    16561 agcataatag caggagataa tgtatcaagc tcaaatatat ctgaaattgc tagaatacgt
    16621 ctttctattt ccttcatttg taatttatct gcattttgca aaatacccac tagattttgg
    16681 actaatgata taaggttctg atatgcacca agttgaaatg tttctcttgc ttcatccatt
    16741 tgaccattca tcatttgccc ttgtgcaaga agtatagatt catttatcat gggaaaattg
    16801 ctgttttgca ataaatcaat cacttgtatg ggttgattta acaatatata acaagttgcc
    16861 tccatacttt ttgcttgacg gcaaatatct atgtcattac aagtttcctg tatacgaata
    16921 aatatttcta atgcttcact aattaatagt tcacgctttt tttcatctac aatatcatag
    16981 tgattaacta ttaaaagacc catccgaaaa atcaaaggaa aacatgaata atattttttt
    17041 atgatttctc ttatttcatc catgacttca tcaaatggtt taaccgtaaa gtctttgcac
    17101 agtttattat acagtttatt aatatcttcc ttcatcattt gaggttcata acatattaac
    17161 tcatcaacgg taatgttgaa atatgtcgcg agttgcggta aaaaggttat gtcaggatag
    17221 ctttgtccag tttcccattt agatacagaa gctttagaaa cgcctatata atttgcaagt
    17281 tcatcttgtg taattccttt ttctttacgc tttaaaatca gcgtttttgc gatgtttaat
    17341 tcattcatgt caatccctcc ttatgtataa ttatatcctt aaacatgtaa agctaacaag
    17401 cgatttgaag ttgacttttg acgaaaaaat caaccacaga gaaacaaata aacaagtata
    17461 taaaatatat atttaaattt atctttaatc tcctttgtaa aatatgtaaa ctttgtaaat
    17521 aaaatccata ttatataaaa ctaatagtta atctatctaa atacagtttt tatttatcac
    17581 gtttttaaat attttgtgta aaacctcttt taatataaac accttatttt catttctcat
    17641 ttcatattct ttttaaaata ctgaatataa ctcttcgatt ttccatttaa tccttttata
    17701 aagttattat tcgtatttat tcctctaatt ataacaggca actatcatgt attggtattt
    17761 gtctattata taaaaatcta taaaagaaaa gcagtcaatc atttagatta actgcttgta
    17821 catatatctt attaaactgt ataaactata atttttatta ttctccattt tcatcccaag
    17881 tcataaatcc ccatccacta tctggataaa tatcgataga cttttctcta atcatataac
    17941 caactttata acactctttt gttattttat tagatagtat acatccttct ccatttatct
    18001 aattccattt aattaacttt tcttttcaac cttaactttt ataaaatcat cttttttaat
    18061 aatttcatac ttattttctc ttcaacatca tcaaatgagg gtgtctcaaa attaactttt
    18121 tacttcataa ggcactcttt tttgtatgaa gtaaaatata ttttcatcat ttcaacaata
    18181 agtaagaggc ttatctctat tttgagacag ccccatttga tggtgttgaa catttaaata
    18241 aggttgaact cgttttatct ctctttttaa gatatctgta aatttgcaca taaagtctct
    18301 tcttctttta caattctaat agttttatta aagccaaagt atatatctcc atattctttc
    18361 gtatatgatt tattggtact ctttcatcta ctccatgacc accagtttta tacgctaaga
    18421 acttaggtcc aaacgccacc atatctttaa accaacttgc atatgtgcca ccacccatag
    18481 caattgtata tccattttca tctgttactt cttcataggc ttctaataat tttttaagta
    18541 ctaaattact ctcatccaca taatgtaagt ctttatgagc aataacctct attttccaac
    18601 cattacaaaa aacctttttg aatctatcta ttatattgtt taaaactata tttttaccat
    18661 accttatatc taactcacat acgatttttt cctcatttac ttttaatatt cctaaattta
    18721 aggtagtgtt tttgaatacc tcatcatatt gattaatccc caatgcatct ccataataat
    18781 cactacaaag gtattttgaa actaattcta tatcttctct atgctgaaaa tccatattat
    18841 cctcaactat ctttattacc attttagata tagcattttc tcccttttca ggattacttg
    18901 catgtacagc tactccttta gtagttaact ctgaaataat tccattaata atttttgcag
    18961 tacaatgaga tggaacaaca ttttctttag ttcctccact tactattatg taaggtttac
    19021 ttttgtcaat tttaatttct ttttctatcc ttatatgaac ccttcctttt tctccattaa
    19081 ccactggata catagcatct ggagtaaatc ccatacttgg aatttcttca cctttatcta
    19141 agtaatattt gatacatttc atacctgtct cctcatttgt accaaaaatt aatcttattc
    19201 ttttattaat tgtaggatac atatcctcta tgtttttcaa tacatgtata agcatagata
    19261 cagcaccctt attatctatg acacctcttc cataaataat attgtcaatt actgctcccg
    19321 aaaatgggtc tacactccac ccctctcctg gtggaactat atctaaatgc attggaatcc
    19381 ctattaattc ctctccctct ccaatttctg catatccaat ataattatca atatttttaa
    19441 cactaaaacc taaactagca cagtaatcta aagttttatc taaagatttt ttaggtccta
    19501 taccaaaagg acattgtgaa ataggttcac cttgttgtga atcaattttt atcaattctt
    19561 ttagaaattc tatggttcta tttaaactat tatctacact tctgcttata tccataaatc
    19621 aacctacttt ctatcttttt aaagcctgtc cttgaagaac aggcttttag cattaaaaat
    19681 tatttttttg taaatactaa ttcacaaact tcatcatcat gagcacattt ttgagcaaaa
    19741 tctaatttaa caccttgtgc acagtcaact cttccataat ccccataaca agctaatcta
    19801 caaatttctt ttctttcttc tttagttaat ccatattctt tccaagcagc atctaatgga
    19861 cagtgatgga attttaaaac gccattctca tctgtatttt ctactaattc catttcaaac
    19921 actttttgtc ctttactgtt atataacatt tctgccattt ttcctggagt atctgctacg
    19981 ttatattttt gacctctcat tttaccaaat ccatatattg cttctttaca tatatcatct
    20041 ggattagctc ctaatttttc agcttctttc ataagaagat agaaccatac tgctctttct
    20101 cctgttgctc ctctaattcc ttctaaatat tccttttctg tatacatttt ttctgacatt
    20161 tctttctcct cctaaaatta aattctatat tttaatcact gtgaattaga atattccaat
    20221 gaatgaccct accaatgcta atacaactaa aattactaat aacttagtta ttgtccactt
    20281 cttgtatttc attccccaat atacgaagaa tacaacacca agtggtaata aacctggagc
    20341 aatcatattt aatgtatctt gaacaacaat tgctttacca ccaatatcaa atgatagcgg
    20401 agttgaaagc ttaactgtag ttgcagataa tgctcccatc ataaacattc ctagaattga
    20461 agcaccatca attatcttat tgacaatacc acctgataga attttcttaa ttgaatctct
    20521 acctaaagaa tatcctaaat gaaataagta ataaccttcg caaaatagta atatactaaa
    20581 cattattggg aaaaatgcac ctataacact tccttctgct ccaaatgaag cacctaaagc
    20641 taagaatatt gtttgaaatg taccaaaatc taaagtatct ccaattccag ccaaaggtcc
    20701 cataagacca ttcttaacac ctgaaataac ttctcctggg atttttcctt cagtagcttt
    20761 ctcttcttcc atagctaaaa ctgtaccgtg aattaatcct ccccatatag cttgagtatt
    20821 aaaaaattgt aagtgtctct ttaacgcatc tactaaatct tcttttctct tatataactt
    20881 ttctaaagcc ggagtgaaac ttgcacaaac tgctaatgct tgcattcttt caaaagagtt
    20941 ggataattct gctgtccacc accatcttag atatgttttt gttacatctt tctttgtaag
    21001 tactcttgtc ttattaactt cagttggacc ttgtccattt ttaacttctt tattttttat
    21061 ttcttgcatt atacttcacc tacccttttg tcttctttca taaaggtaat taaaagagct
    21121 atacaaacac caaatattgc agctgcagta attgatattt caaaatattg aaccataaaa
    21181 aatcctataa taaacattgg taaaaattta tttttaccta tagtaaatat tgttgttgca
    21241 aaacctaatg caggtaatat accgcccatt actgttaatc cattcattaa ccattgtggt
    21301 ataacatcta ataatgattg aactaaatct gctccaaaaa agttacatac aaaaactatt
    21361 ggaaacctta aaacaaaccc aaatattaaa gaataaagtg ttgcacatct ccagatgcct
    21421 tttgtattac cttcttcagc atacttatct gccttatgaa ccaatacagc attaccagtt
    21481 cttcttaagt tattaactaa tactcctata acacctaaag gtaccgcaat agatactgca
    21541 acttctgcat taacaccagt ttgaagtgct actggtattg caataagagc agctagacat
    21601 ttatctgatg gaatatttcc ccctgctgcg accattccta gataaaccat ttctatactt
    21661 gcaccaacaa tcataccagt tgttacatca ccccaaagta atccaaggct aaaacctata
    21721 aataaaggag actttagtgt tgagaaaagg gtataccctg caagacctgc tgcaaaccaa
    21781 taccataatc ctgttacaat tgccaacatc aaaacagatt ccatttataa ttcctcctaa
    21841 tttatatttt ttatttaaat ttctttaacg cattttcata tgtcatagat gattcctctg
    21901 gtataacttg taggactatt tcaaccccat tttcattaag ttcattaagt tgttctacat
    21961 cctcatttcc taatgaaaca gctgtaaaca ccattttctt tcctgcttca tttggaatac
    22021 ctcctaattg aatcttttca tatttaagtc cagctttata agccttattt gccatatcaa
    22081 catttttaaa tagaataaat atatttttat ctcctaaagt gttgttttgg aatgcttgtc
    22141 ccgcatcttc tgctgttaaa ataactactt ctactcctga tggtgctgcc attttatata
    22201 tgtcagccat aaattcatct tgacctaaga agtcatcaac tattattatt ttttgagctt
    22261 gagcgatttt tacccatttt gttataactt gcccatgaat taatctgtgg tctactctta
    22321 ctaatgttat ttttgccatt atattcacct cataatttat atttttttaa attctttaat
    22381 taaatccaca caaaggttat tatttttttt gacgattctt tctggtaatg tatgtaattt
    22441 atcttctttg cttaattctt catctacgat taaaattgtc tgtaagctaa gtccatttat
    22501 tgcatctatt cctcttctta tagcaacagc tattgcaaca cttgatgtag atcctccata
    22561 taaatctgat attataattt tcacatcttc tttatctact acttcttcaa cctctttcat
    22621 aaatacagaa acatcttttt cagaacttag tgataaaact tcatattgat ttgacaatcc
    22681 aaagttttta tttgtttctt ctactaagac ttttccccaa gttccatggc acagtatgat
    22741 taccttatat ttattcattg ctaaataaac tctcctttat agcgattaat attttggttt
    22801 aattctactt cttcttcatc aggtaccatt tgaattgata cattaatatt ctttttaata
    22861 aattcatcta ttaaaagaaa ctctttttta ttaatgtata cattttgaga tattttcttt
    22921 tttcctattc ctgtaggtat tcttccaaca ataagttttt tgatattaat cccttcttct
    22981 atcattctat ttgcagtatc taaattttta attaatacaa aaacgttatc atcagcttga
    23041 ttattataaa aatatctcct tgattcactt acagttaata ttgataaatc aatattcttt
    23101 ggtgctgcca tttttatcaa acctttagca ataacatcat tggttgtttc atcatctact
    23161 actactatct tttttacacc tagatgctta acccatttat atataacttg accatgtatt
    23221 aatctatcat cacatctgca atattttact aaagacattt ttaatcaaac tcctttttct
    23281 attacattga gctaagaact ttattaatat tgtttatacc agtttgtcct gcttcaatac
    23341 atgcttctgc taactcttct aaactttttc cctctctatt aattaaagct tcaagtagca
    23401 ttggaagatt tactccagta agtgcatgaa acttgccacc ttttttaagg tttaaacttg
    23461 caacattact tggcgaacct cctaataggt cagctaatac taaaactccg tcaccttcat
    23521 ctaattcatt taacttttct acaaaatttt tatttaagtc ttcaatatta tcattcctat
    23581 ttagtttaat tgctgctgtt ctttctgctg gtcctgcaat aagttcacag ctttttataa
    23641 tttcttcact aaaactccca tgagtcataa ctattattcc tatcaccaat ttcacctcac
    23701 ttttcttgtc actttttata taagcaattg ccgtgccaac ttatgtgtat caataacaaa
    23761 tggctatttt acaggattta atcaaaactt tttactcaat tttttttaaa aacttattat
    23821 ttcgatatgt atcaaaagat tttttcaacc tgtatcaaat ctgtatcaaa aaaagtaaaa
    23881 aaaagatagc cttttggcta tttttaaatt ttgtatcaac ttttgaattt atctgtatca
    23941 tattgtgatt caaatatatc taatatattt gcatattcca tatctgaaat aattatatcg
    24001 aatgtctctt ctactagctt aaaactttct tttataacta aatataattc tttatttcta
    24061 ctaattcttt cttcatatga tttataaact aaagactctt ttattattac tctttcaatc
    24121 atacatgaac aatgaaatat aaactttact aaaagttcat cttgaattac taaagaatag
    24181 tgttcactaa ttctattaat tacttctttt aatataaaat aagccttttc cccatttaaa
    24241 aaagtcaaag ttttactaat attatcaatt agtaatctat caaaatatct accaccatta
    24301 tctttttcag catatgtaac ttccatatct ccataatgtt tctttataga ttctataata
    24361 ttaaaatata atttctctaa tgtcatttct ggagttagag cctttctagt tgcttctatt
    24421 acaataggtg tacttaccat atctattgct tttacttctt ttcctgtagc atcacgaata
    24481 actttagcaa atgttaaaat agaccccata tcagttaaaa ttaaaattcc ttttccttta
    24541 tcaattttat tggctatttc tacagcttgt actaaaatat cctgaactct atcttctaat
    24601 cccatattaa ttgccactgc atggttacaa tccagtaaag tattggctac attcaccatg
    24661 ctagatgctg tagattcacc atgcattatg actaatattg ctatactctc ctcatttaat
    24721 cccacatacg ataaataaag aaatgttgct aaaaaaattg cttcatcttc tggaaactct
    24781 actccataca ttaatgacat gttagataat atttcttttg ctatgttata ttcatatgct
    24841 ctttccttca taatttcatc tttattagga tgctttacta tatttccaat ctttattctt
    24901 tcaattaaat tctgaatatg taaagctata gcttttatta atttatctaa tccttctctt
    24961 ttgctccatt tatcatgctt ttgtaaaata tattttacag tagttgcaat tgaatcatta
    25021 acaatgttgt tataagctgt ttgattacta ctattatata taaaagtatt cattaaatta
    25081 taggaatact tctgtatgtc tccatctata acacttctaa tttgtgactc tttaatacct
    25141 tcttgttgaa gtttattcca agtttctttt atcattccat aaaaatctaa atcatatttt
    25201 ttattttcta ttaataaatt ttcactttca aaatcctttt cttctggtaa aaaaataata
    25261 tcatcttttc caataaaact gaaattttgt acaaactcct cttttctatt atttccatat
    25321 aatgattctc taatattatt tggtagaaga gagagcctta catatacaca ttccctttta
    25381 taggtcatat aatctaaaaa agctcttgca caaattaatt gtatatcgct ttttaattgg
    25441 cctatgtttc ccttacactt atataaaata aatgccttaa taacttcttt tgaaaccttt
    25501 aacttaacac caatcctaac actctcttct ttaaaaaaat aacatataag cttcattctc
    25561 tcttgaaagc ctctttcctc taaagacgga atctttatag ttacaggtat tcttcttaaa
    25621 aacgtttcca acattgctgt ttctgggtct tctgtagtgg ctgcaattat cataactcta
    25681 cactcgtgta ccttattagc ctctcctaac cttctatata tccctttatc cataagcaga
    25741 aatagcattt cttgtccctc tgcagataat ctatgaactt catctaaaaa caatactcca
    25801 ttattagctt catgtacaat accatactta tctttatcag ctccagtaaa tgctcctttt
    25861 acatatccaa aaagctgcgc taataataat tgctgattat cagaataatc agcacagtta
    25921 aatatgataa atggtgcatt atcactatct tcttttatag ttaaactata cttatacata
    25981 tattctgcaa atatagattt accaactcct gtaggtccta ttattaatgt actcaacccc
    26041 ttaggtggat atattactgc tgctttagcc tgttctattt gggaccttaa acttccatca
    26101 catcctacta aattaaaaat attgttctct ttttttatac tctctaaaat atactcatct
    26161 ttgatagaat cattttcact atattcgttt atagagttaa tattatcaaa tatcccttta
    26221 tttagtttct ttcctaaaat actctcaata ctttctttat ataagtactg aacaggctta
    26281 ccctttatct ttataataat actttctttt attaattgat ttaattcctt actagcatta
    26341 cttctattta tacctacttc agtagctata tattctgcat caaatccaaa tctaatgcca
    26401 ttattaaagt tcaagtgttc ttctgttaac cttttcaagc aaattaaaac tttttctttc
    26461 cttgatagct tcttttgtgt catagttaac ctcccctata agcagtaata ctgttaaaca
    26521 tttattatta agcttaattc tacaatattt taatattttt gtctaattat gtaactattg
    26581 attttctttc ctattcgttt tataatataa attacgttac cctcatcttt tatagaggag
    26641 gaatttatat gaatttttta tcagatttac acacccactc tatagtcagt ggtcatggct
    26701 atagcacttt actagaaaat attaattatt gtaaagaaaa tggaattaag atactaggta
    26761 catctgaaca tggtcctaag atgcctggtt ctccccacaa atggtacttt cacaacattc
    26821 aaaatatccc aagaatcata aataacatta taattttaag aggctgtgaa gcaaatatac
    26881 tagatattaa aggaaacata gacctagagc cttttgtaat tcctcggtta gattatctta
    26941 tcttgtcatt tcacgaagct gtgttttctc caaatacatt agagaataat actaaagctt
    27001 taataaatgc aataaataag catgataata ttgaaatatt aggacacctt ggaaactcaa
    27061 actacccaat cgactatgaa ttaatcatta aattagctat agaaaagaat atcttaatag
    27121 aaataaataa ttgttctatt aaaggcgtgt caagaaatgg tagctcggat aactgtaagt
    27181 atattgctac actttgcaaa aaatatggtg ctaaaatcat actgacttca gatgctcaca
    27241 tttgttttga cataggtaac tatgagtatt ctgaaaatat cttaaaggaa attaattttc
    27301 cagatgaatt aataatgaat tatcctaaaa aacttattaa tcattttcac caaaaaggta
    27361 aattactaga tgttgattat acaaatatct aagtaataat acatgcttac tttaactcc
//
LOCUS       DAEQCW010000044        27401 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.044, whole genome shotgun sequence.
ACCESSION   DAEQCW010000044 DAEQCW010000000
VERSION     DAEQCW010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27401)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27401)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27401
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.044"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            78..1772
                     /locus_tag="KRO40_001926"
     CDS             78..1772
                     /locus_tag="KRO40_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M3 family oligoendopeptidase"
                     /protein_id="HBH2092746.1"
                     /translation="MKFSEFKYERPNYNSMKKEFLSCVEDINNSRNYKEQQKNIHKIN
                     LLRNKIETLSNIASIRYSTDTFNKFYKEEKNYWDEYMPLYEELNSYFYNAIVNSKFKY
                     DLIKEFGEQFFTIVEYSLKSFSKEIISELQEENKLCSEYTRLLASAEIMFDGKIRNLS
                     GMGKFMYSKNRKTRELANKAYYNFFEENETKFDDIFDKLVKLRDKMSKKLGFEDFVEL
                     GYVRMMRSDYREYMIKNVRKQVLKYVVPMANELYEKQAKRIGLEYLSYIDEGVEFLTG
                     NASLKGDSRYIIKNGKRMYSELSKETNEFFDFMLENELMDLETKKGKGAGGYCTYIPD
                     YKSPFIFSNFNQTADDIDVLTHEAGHAFQLYMSRWIDMPEINFPTLDSCEIHSMSMEF
                     ITWPWMDLFFKEDTDKYKFTHLSSSIKFIPYGVIVDEFQHYIYKNPNVDKSKRKEIWR
                     FLEKKYLPHRKYGDNSFLERGCWWFKQGHIFKNPFYYIDYVLAQICALQFWKKMIQDR
                     DAGWKDYINICKVGGTKSFLDIVSMGNLYSPFDDGCIESIIGDVKSWFDEINDSKL"
     regulatory      2104..2214
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            2318..2689
                     /locus_tag="KRO40_001927"
     CDS             2318..2689
                     /locus_tag="KRO40_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrdX family protein"
                     /protein_id="HBH2092747.1"
                     /translation="MIIITNNPKVKEEVQGREVLFKDTTYIGILEASRDLIHEGYELL
                     SHPLYGSVKPNETPYRTVILKKGNRLDINSLTLIEEAIITASKFQNNKKTPKWTESVQ
                     DDFRVIDYDIFYNTIQRMQYE"
     gene            2786..3733
                     /gene="trxB"
                     /locus_tag="KRO40_001928"
     CDS             2786..3733
                     /gene="trxB"
                     /locus_tag="KRO40_001928"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBH2092748.1"
                     /translation="MENVYDLVIIGSGPAGLAAGLYGARAKLKTLILEKDKTGGQIVI
                     THEIANYPGSVPNATGPSLIARMVEQCKEFGAEMLRDNIVDTELDGDIKVLKGEKAEY
                     RAKAVIIGTGATPRKIGCPGEKELTGKGVSYCATCDADFFEDFEVFVVGGGDSALEEA
                     MYLTKFARKVTIVHRRQGFRCAKSVEEKAKANPKIEFLLDTVIEEIKGDGILESVVFK
                     NKVTGETHEYFADEEDGTMGVFVFVGLDAQTDLFKGKVDMDEKGYIITDEDMRTNIPG
                     VFAAGDCRSKTLRQVVTATNDGAIASIVAEKYIDEKFGN"
     gene            3837..4154
                     /locus_tag="KRO40_001929"
     CDS             3837..4154
                     /locus_tag="KRO40_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol reductase thioredoxin"
                     /protein_id="HBH2092749.1"
                     /translation="MLDLDKATFEEEVLNAEGFVFVDFWSEGCEPCKALMPDVHKLAE
                     TYGDKIKFCKMDTTKARRLAIKQKVLGLPTMAIYKDGEKVDEVTKDDATVPNIENMIK
                     KYL"
     gene            4423..5709
                     /locus_tag="KRO40_001930"
     CDS             4423..5709
                     /locus_tag="KRO40_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006439082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBH2092750.1"
                     /translation="MRLELGKIFIKDIQFGDVTEVKDGVLFINKQEMLQEIGGDEHIK
                     SIDIELARPGESVRITPVKDVIEPRVKVEGNGGIFPGIMSKVDTVGEGKTHALKGVAV
                     VTTGKIVGFQEGIIDMTGEGAKYTPFSKLNNVVVIAEPIDGLKQYAHEKAVRMIGFKA
                     AMYLGEVARNLTPDEVSVYETKPLLESIKEYPELPKVGYVYMLQTQGLLHDTYVYGVD
                     AKQIVPTLLYPTELMDGAIVSGNCVSACDKNPSYVHINNGVVEDLYARHGKDINFVGV
                     IITNENVYLADKERSSNWTSKLCKYLGLDAVIVSQEGFGNPDTDLIMNCKKIEMQGVK
                     TVIVTDEYAGRDGGSQSLADADVRADAVVTGGNANQVVVLPKLDKVIGHLEVVDVIAG
                     GSDGSLRADGTIEVEIQAITGATNETGFGHLTAKGY"
     gene            5821..6294
                     /locus_tag="KRO40_001931"
     CDS             5821..6294
                     /locus_tag="KRO40_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:5953..5955,aa:Sec)
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase complex
                     selenoprotein A"
                     /protein_id="HBH2092751.1"
                     /translation="MSLLSNKKVLIIGDRDGIPGPAIEECVKTVEGAEVVFSSTECFV
                     UTAAGAMDLENQNRVKDAADKFGAENVVILLGAAEAEAAGLAAETVTAGDPTFAGPLA
                     GVALGLSVYHVVEEPIKSLFDESVYEDQISMMEMVLEVEEIEEEMSGIREEFCKF"
     gene            6326..7636
                     /gene="grdB"
                     /locus_tag="KRO40_001932"
     CDS             6326..7636
                     /gene="grdB"
                     /locus_tag="KRO40_001932"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:7373..7375,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBH2092752.1"
                     /translation="MGKLKAVHYINQFFAGIGGEEKADTKPHVAETLPPISLQLDKLL
                     GEDIEIVGTVVCGDSYFNENIDSASEEVLSMVKGFEPQLFIAGPAFNAGRYGVAAGTI
                     TKVVKDALNIPALTGMYVENPGADMFKKDVYVVETSDSAAGMRKALPKIAKLAVKLAN
                     GEEIGTPKDEGYIARGIRVNYFHEDRGSKRAVDMLVKKIKGEPFETEYPMPNFDRVDP
                     SKAVKDLSKCKIALVTSGGIVPKGNPDRIESSSASKYGTYSIAGVMDLTEETYETAHG
                     GYDPVYANLDADRVLPVDVLRDLEKEGVIGKLHETFYTTVGNGTSVANSKKYASEIGA
                     ALVADGVDAVILTSTUGTCTRCGATMVKEIEKTGLPVVHMCTVVPISLTVGANRIVPT
                     IAIPHPLGNPALDPTEEKALRRGLVEKALNALTTEVDGQTVFEK"
     gene            7892..9424
                     /locus_tag="KRO40_001933"
     CDS             7892..9424
                     /locus_tag="KRO40_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014520415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III family protein"
                     /protein_id="HBH2092753.1"
                     /translation="MTYPVLKGAGYVLIHTPDMIVQNGSTCTVERATNPDSEFLKEVS
                     NHIRSYEDVVNYMPNQVYIGNRRPEELRDLPMPWCEQKIEGTRNGKFGEIMPQDEFIA
                     LMQISDAFDLVKLSQEFIDEVKPKIENNYPEIAPFVGKLKGDDIEEGKELVATHIAEG
                     LYHDGKFVGYVKRAHDVDVNLNAHTMFENLVVKASGVLSAIQMLRHSKIDPAEIDYVI
                     ECSEEACGDINQRGGGNFAKSIAEIAGLQNATGSDTRGFCAAPTHALIQAAALVKAGI
                     HKNVMVVAGGASAKLGMNAKDHVKKGLPVLEDVVGGFAVLVSENDGVNPVIRTDLTGK
                     HTVGTGSSPQAVMTALITSGLDRANLKITDVDVYSVEMQNPDITKPAGAGDVPEANYK
                     MIGALAVKRGDLEKKELKDFVSNKGLPGWAPTQGHIPSGAPYIGFLIDDLTTGNRNRA
                     MIVGKGSLFLGRMTNLFDGVSFIAERNTGVTEETSGISKDEIKKIIAESMKKLALDML
                     EE"
     gene            9435..10580
                     /locus_tag="KRO40_001934"
     CDS             9435..10580
                     /locus_tag="KRO40_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine reductase"
                     /protein_id="HBH2092754.1"
                     /translation="MSKKVIADVFLEVANAIESGEFGKKVKIGVTTLGSEHGVENMVN
                     GAQLAKSNLFDIVLIGPKVETDLEVVEVNDEKEMHAKMEELLDSGYIDACVTMHYNFP
                     IGVSTVGRVITPAKGKEMILATTTGTSATNRIEAMVRNAIYGIATAKSMGNKCPKVGI
                     LNVDGARQVEKCLKELKDNGYDMEFADSIRADGGCVMRGNDLLVGAPDVMVTDTLSGN
                     IFMKVFSSYTTGGDYEAQGFGYGPGVGEDYDRKVLIVSRASGSPVVANALKYAYDVVK
                     GDISNVARNEFAKVKKAKFDDIISSLTKKEVKAEKVEVKMPDKEIVTRQIAGVDIMDL
                     EDAVSELWKNGIYAESGMGCTGPIVLVNEAKGDLAVETLVKAGYTAK"
     gene            10890..11969
                     /locus_tag="KRO40_001935"
     CDS             10890..11969
                     /locus_tag="KRO40_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2092755.1"
                     /translation="MSRVKNVVELLETKGVDALYLTKKTNVNYISGFPDEEAYAVICK
                     DGNFLVTDSRYMELAEKVCKDFEIINWHNFDRSVAKAVKSVCDKVGIKKLGFERTNIV
                     FDKYEELKNLIEKDNGELIPTENIVETLRYVKDKDEIKNTRKACEIADKALEELIPHI
                     KAGVSEIELATKLEYFMKMNGAQNIGFETILISGAKTSLLHGKPSDKIIEKGDFVLID
                     YGAMYNGYISDTTRTFIVGGASEKQLEIYNLVKEAQNVGVENMKAGVHATIPDAEIRK
                     VVKKYEDYYYQGIGHGVGRDVHEEPFIGNYGDKIIEEGCIITMEPGIYFPGWGGVRIE
                     DTVLITKNGPERLTKFPKDLMILDK"
     gene            12082..12681
                     /locus_tag="KRO40_001936"
     CDS             12082..12681
                     /locus_tag="KRO40_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092756.1"
                     /translation="MYKKHKFIKNIKKAWYKIKLIDRCLIIVMAILMFQSIYNLFVNE
                     VNSQDTTTIDVVVRTTSAAIFGYFLSANFIKRPLRKYTNTDVSSNLFIDNNLSPKGQE
                     SNQNNIMNVKNTIGFTSEADNYEKKIPINNNEGFEEGETSELQIIIATVICIVALTVL
                     FVVRNFTTTTSASLGTISQMRDFVSGCVGFLLGCPSKPD"
     gene            complement(12867..13739)
                     /locus_tag="KRO40_001937"
     CDS             complement(12867..13739)
                     /locus_tag="KRO40_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2092757.1"
                     /translation="MNINYLYYFQTVCKYKNMTKAAESIHISQPSITLAIKELEKELG
                     FELFYRIGNKIELTPEGKIFLDKSKHFIKQFEDFQCDALDLGKKRKASLKIGIPTVLG
                     TFLLSKILPRFNVIYPDIELKIFEVPTFVGAKMIEESTLDFCIGIIDSDIYDDIDSKT
                     IYKTELYLVTNPKNELAKHPIISNYMLKNVPFVILSEGSYHYKIITKRLEKAKPNIIL
                     HSNQLSTIRYLLENDLASTILYKEIFQNTENLCSIPLERAITANIGVLWRRNQYISHS
                     MKLFIEYMASIHIN"
     gene            14156..15559
                     /locus_tag="KRO40_001938"
     CDS             14156..15559
                     /locus_tag="KRO40_001938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092758.1"
                     /translation="MKGSDLVKFELMDFLMNPFVLMFAAVITGILFGKIKFGKFNFGV
                     SGALFTGLFIGWLAYSLGNLIIAKGETAAGYKAATVMMGNGIISSDFFDFFLIIFVAA
                     VGLLAAKDMKAVLKKYGARFVILGVLITFIGGSMTYAMTLLSSDKGSSAYEVSGVYTG
                     ALTSSPGLAAALETAGKHAEDVSKEFEKASIKDKKEILKVVDPEGKLDVNTTTSLTQE
                     QIDKYIAYAEAGVGIGHAVAYPFGVLIVILGVNFLPKLFRMDLKEERRKYEKEMKEAR
                     DSVSGKTIPEVPFNIITFFLTCLAGYLVGGIHVFMGPLGYFTLGATGGSLIVSLVLGY
                     IGKIGVVNFRMEEKVLNILKQIGLVFFLAIVGLRYGGKVVDSIMTSGMHLALVAIAVG
                     VTAMMIGFLVGKYVFKLNWILLSGAVCGGMTSTPGLGAAVDALDSDDPAAGYGATYPF
                     ALLTKVILVIVLHKLPM"
     gene            15586..17130
                     /locus_tag="KRO40_001939"
     CDS             15586..17130
                     /locus_tag="KRO40_001939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBH2092759.1"
                     /translation="MNNEGAFEELSGRLRNKELCDLIMNADEAAKIIEDGMVIGVSGF
                     TPSGYPKAVPLAVSERAKSGEKIKLTVYSGASLGPEVDGAWSEAGIIERRLPYQTNSI
                     LRNNINKGVVDYIDMHLSHSTQFLNYGTIPKVDVAIVEALAITEEGNIIPTSGIGNSP
                     SFIKSADKVIVEINLAKPMEMEGMADIYITENPPNRKPIEINHPKDRIGTTYIPCGLD
                     KIAGVVITNMQDKTRPLGVVDEASKKISNNIIAFLREEVKAGRLSKNLLPLQSGVGSV
                     ANAVLYGLCESEFENLTCYTEVVQDSMLDLIRMGKVTMASTTSVSPSPEGLIKFEKDI
                     DFFKDKIILRPQEISNNPEIARRIGVIAMNTAIEVDIYGNVNSTHIMGSKMMNGIGGS
                     GDFARNGAITIFSTESIAKNGDISSIVPMVSHVDHTEHDVMVIVTEQGYADLRGLAPR
                     ERAIKIIENCAHPDYKEQLRDYLNRACKSGAKQTPHILDEALSWHSKFMSTGTMKKAE
                     TFKSAL"
     gene            17161..18552
                     /locus_tag="KRO40_001940"
     CDS             17161..18552
                     /locus_tag="KRO40_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="HBH2092760.1"
                     /translation="MEKAVENFEDLSKEYINGYIERARKAQREFECYTQEQVDKIVKI
                     VGKVVYYNAEYLAKLAVEETGMGVYEDKVAKNKSKAKVIYNNLKDKKSVGIIDIDRET
                     GITKVAKPVGVVAAITPCTNPIVTPMSNAMFALKGRNAIIITPHHKAIGCSTKTVEMI
                     NEELEKIGAPENLIQILDQQSRENTRNLISSADVVIATGGMGMVKAAYSSGKPALGVG
                     AGNVQCIIDRDVDIKEAVPKIIAGRIFDNGIICSGEQSVIVAEEMFDKIMDEFKNNKG
                     FIVRDKVQKEAFRNAMFVNKSMNKDAVGQSVHTIAKIAGVEIPEDTKIIVIEADGPGE
                     EDIIAKEKMCPVISAYKYKSFEEGVAIAKANLNVEGKGHSVSIHSNTVKNIEYAGENI
                     EVSRFVINQCCATSAGGSFFNGLAPTNTLGCGSWGNNSISENLDYKHLINISRIAYYM
                     PENEVPTDEELWG"
     gene            18745..20241
                     /gene="abfD"
                     /locus_tag="KRO40_001941"
     CDS             18745..20241
                     /gene="abfD"
                     /locus_tag="KRO40_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyryl-CoA
                     dehydratase/vinylacetyl-CoA-Delta-isomerase"
                     /protein_id="HBH2092761.1"
                     /translation="MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVA
                     ATYDLAHDPEYADLMTVTSNITGEKINRFGHLHQSVDDLIKKVKMQRLCGQKTASCFQ
                     RCVGMDAFNAVYSTTFECDKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLS
                     PSAQPDPDMFLHIVERREDGIIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVSF
                     AVPSDAEGVFMIYGRQSCDTRKLEEGADVDLGNKEFGGQEALVVFDNVFVPNDRIFLC
                     GEWDFSGMLVERFAGYHRQSYGGCKVGVGDVIIGAAALAADYNGANKASHIKDKLIEM
                     THLNESLYCCGIACSSEGHKTEAGNYQIDLLLANVCKQNVTRFPYEIVRLAEDIAGGL
                     MVTMPSEKDFKSDLKVGTSGMTIGEVCNKYFKASSVASTEERMRILRFLENICLGSSA
                     VGYRTESMHGAGSPQAQRIMISRQGNINQKKELAKKIAGIKKEEALNL"
     gene            20376..20651
                     /locus_tag="KRO40_001942"
     CDS             20376..20651
                     /locus_tag="KRO40_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092762.1"
                     /translation="MTCGVRFCGGCNPRYERGKALTIIKEHFNGRVDFSIAQENVEYD
                     LLLIIGGCATLCASYQQYKVKNECVKMWDFSHIERVINVIESAICET"
     gene            20675..21982
                     /locus_tag="KRO40_001943"
     CDS             20675..21982
                     /locus_tag="KRO40_001943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBH2092763.1"
                     /translation="MSWQELYQSKLCSATEAVKQIKNGDTVVFAHCVGEPPALVEAMI
                     ENAEQYKDVEIKHMVSLGSGGYTAKGMEAHFRVNPMFVSGNVRKAIENGDGDFTPAFF
                     HEVPKLLREKRLKCDVVLAQVTPPDEHGYCSLGTSVDYTYEAIKTARTVIVQVNDQFP
                     RTYGEVVHVSEFDYIVEKSQPLFELQPAKIGEVEEAIGKNCASLIEDGSTLQLGIGGI
                     PDAVMLFLTDKKDLGIHSEMISDGTLALYEKGVINGKYKNFDKEKMTVTFLMGTKKLY
                     DFANNNPAVEVKPVDYVNHPAIIMKQHKMVSINSAIQVDLMGQVVAEAMGLRQFSGVG
                     GQVDFIRGVSMGEDGKAIIAMPSITTKKDGTVISKIVSIVDEGAPITTSRNDVDYIVT
                     EYGIAELKGKSLRERARNLINIAHPSVRESLAVEFEKRFKEKY"
     gene            22002..23120
                     /locus_tag="KRO40_001944"
     CDS             22002..23120
                     /locus_tag="KRO40_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyrate dehydrogenase"
                     /protein_id="HBH2092764.1"
                     /translation="MEALRVVPKIFYFDTFKEFNEEFKIGKNDLVITNEFIYEPYMKP
                     LGIDTNLIFQEKFGTGEPSDEMIDSMTKEMKKYNFDRIIAFGGGTIVDICKILALDVP
                     EKSIDLFEGEVSPKKVKELVVVPTTCGTGSEVTNVAIAELKSKHTKKGLAVEETYADY
                     AVLIPETVKGLPYKFFVTSSVDALIHAIESYLSPKASPFTEMYSLQAIKMIMDGYKKI
                     VDKGEEERFNHLRDFVLASNYAGIAFGNAGCAAVHALSYSIGGAFHVAHGEANYQFFT
                     EVFKMYSRKKPNGKIIKCTKILADALECDPNCDVYGELEKFLNKLIAKKALREYGMVE
                     SQIDEFTDSTIANQQRLLANNYVELSREEIREIFANLY"
     gene            23407..24327
                     /locus_tag="KRO40_001945"
     CDS             23407..24327
                     /locus_tag="KRO40_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-bromo-4-chloroindolyl phosphate hydrolysis
                     family protein"
                     /protein_id="HBH2092765.1"
                     /translation="MYKSENFSKKSVLINSFLSKFLKIIGWGLVSLFTLSALVLSTIS
                     IIIGWAVILPIQVCAVFLLIGGVCIFKGKRLGDQISRYKKYCTIINNRNIIPVELIAE
                     NTSKSLNFIIKDVQKMIDKNYFINTYIDKRNNQIVLTNEDFVPPRYEDVAYEVKEEEK
                     TDESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKL
                     TQIQKFMDYYLPTTLKLLNSYHTLEEQGIDRENITTTMESIENTMNTIVVAFENQLDY
                     LFEDEAIDISTDITVLENMLVQEGLTSGKF"
     gene            24442..25599
                     /locus_tag="KRO40_001946"
     CDS             24442..25599
                     /locus_tag="KRO40_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBH2092766.1"
                     /translation="MNNLDDIPVMPTLTLDPFGEESNTNDIDNSDLLMKKDEKDPEEE
                     KLSESERKMVKEFAEKIDITNTNMILQYGAGAQKKVASFSETALKSVKTRDLGEVGDM
                     LTNLVTDLKAFSADEKEQSGFLGIFKKANNKISNLKTKYDSAEVNVDKVSKELQKHQV
                     KILKDIAMLDKMYELNLAYSKELTMYIIAGKQKLKDMKEYEMPKLREKARLSGSTEDA
                     QSVNDMVSLCDRFEKKIHDLELTRMVSLQMAPQIRLVQNSNNLMAEKIQSTIVNTIPL
                     WKNQIVLALGISHLNQAMKAQREVSNMTNELLLKNAETLKMGTIETAKESERGIVDID
                     TIKKTNQSLISTIDEVVKIQHDGRIKRQEAEVELSKIENELKSKLLEFTVK"
     gene            complement(25684..27183)
                     /locus_tag="KRO40_001947"
     CDS             complement(25684..27183)
                     /locus_tag="KRO40_001947"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HBH2092767.1"
                     /translation="MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGE
                     EADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFIYGSQTIENEAAMVARVKSHKAG
                     FVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLD
                     TKVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSH
                     KENPLELLDSSKRYVVGAGINTRDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDF
                     IREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICITREQKGIGRGQATS
                     IIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPT
                     NKVNINGSYMKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLS
                     LSKVRSTMCNCGALSIPELQKNAKLTLVSSTSIVEGGAHDVMLKDNRNL"
BASE COUNT        10691 a         3123 c         5164 g         8423 t
ORIGIN      
        1 ataaaagagt attacatagt acatgtaaat ctatatttat aaatacaata aagtaaagtt
       61 gtaaaggagt gctttaaatg aagttttcag agtttaagta tgaaagaccc aattataata
      121 gtatgaaaaa agagtttttg agttgtgtag aagatataaa taattctcgt aattataaag
      181 agcaacaaaa aaatatacat aagattaatt tattaagaaa taaaatagaa acgttgtcaa
      241 atatagcttc gataagatat agtacagaca catttaataa attctacaaa gaagaaaaaa
      301 attattggga tgaatatatg cctttgtatg aagaattaaa ttcatatttt tataatgcca
      361 ttgtaaattc aaaatttaaa tatgatttga taaaagagtt tggagagcaa tttttcacaa
      421 tagtagagta ttctttaaaa agtttttcca aagaaataat aagtgaattg caggaagaaa
      481 ataaattgtg ttcagagtat actagacttt tagcttcagc tgagataatg tttgatggga
      541 aaataagaaa tttatctggt atggggaaat tcatgtattc taagaataga aaaacaagag
      601 aattagcaaa caaagcatat tataatttct ttgaagaaaa tgaaactaaa tttgatgaca
      661 tatttgataa attggttaaa cttagagata agatgtctaa aaaattaggt tttgaagatt
      721 ttgtagagct tgggtatgtt agaatgatga gaagtgacta cagagaatat atgataaaaa
      781 atgttagaaa acaagtacta aaatatgttg ttccaatggc aaatgagctt tatgaaaaac
      841 aagctaaaag aattggtcta gaatatttaa gttacataga tgaaggcgtg gaatttttaa
      901 caggaaatgc aagtttaaag ggagattcaa gatacataat taaaaatggt aaaaggatgt
      961 attctgaact gtcaaaagaa acaaatgaat tttttgattt tatgttagaa aatgaactta
     1021 tggatttaga aacgaagaaa ggaaaaggag ctggagggta ttgtacttat ataccagatt
     1081 ataagtcacc attcattttt tctaatttta atcaaactgc tgatgatata gatgtattaa
     1141 cacatgaggc aggacatgca tttcagttgt atatgtctag atggattgat atgccagaaa
     1201 ttaattttcc aacgcttgat agttgtgaaa tccattcaat gagtatggaa tttataacat
     1261 ggccgtggat ggatttattt tttaaagaag atacagataa gtacaaattc actcacttat
     1321 catcttcaat taaatttata ccttatggag taattgttga tgaatttcaa cactatattt
     1381 acaaaaatcc taatgtagat aagtcaaaac gaaaagaaat ctggagattt ttagagaaaa
     1441 aatacttacc tcatagaaaa tatggtgata attctttttt agagagaggt tgttggtggt
     1501 ttaaacaagg acatatattt aaaaatccgt tttattatat agattatgta ttagctcaaa
     1561 tttgtgcgtt acaattttgg aaaaaaatga ttcaagatag agatgcagga tggaaagatt
     1621 atataaatat ctgtaaagtt ggaggaacaa aatcattttt agatattgtg agtatgggaa
     1681 atttgtattc tccatttgat gatggctgta ttgagtctat tataggtgat gttaaatctt
     1741 ggtttgatga aataaatgac agcaaattat aaaaaattat gagaatttta ttgtataaaa
     1801 gtgaaaaatt aaaaaatata taaaaagtga ttatttgttg tgaaaatagt cttgttttta
     1861 actaaattga taaaataaac taaaaaagat ttgtacttaa aaaaaaaaga aaatacaaga
     1921 aatatgcaat atcaacattt ggaaaaaaaa gtaaaaatgt atacaaaata catataaaaa
     1981 aactattgca aattttatag aatgtttata tacttaagtc aacagagata gaaaaaagct
     2041 atttatagaa aacaaaggat aaattgctta attttaaatt ttctgaaaaa aataataatc
     2101 cggatgaaga gtatgggaga ctgctttata aaaagcgacc gaagggacaa gtttaatctt
     2161 acttacccaa aagattagat gaaattctca ggtaaaggtg actgtacttg gacggggctc
     2221 tgaaaatgat tttaacaggg aagacaaatt gggagatttg tttttcctgt tttttattta
     2281 tcaagtaata aataaaagtt tgaaagagag taaaaaaatg ataataatta cgaataatcc
     2341 aaaagtaaaa gaagaagttc aaggcagaga agttttgttt aaagacacaa cttatattgg
     2401 aatcttagaa gcaagtagag atttgataca tgaaggttat gaacttttat ctcatccact
     2461 ctatgggagt gtaaagccaa atgaaacacc ttacaggact gttatactaa agaaaggaaa
     2521 tcgtttggat ataaactctt taaccttaat tgaagaagca atcatcactg caagtaaatt
     2581 tcagaataat aaaaagactc caaaatggac agaaagtgtt caagatgatt ttagagtaat
     2641 tgattatgat atattttata atacaataca aagaatgcag tatgaataaa aaaaaattgt
     2701 taaaaagtta ttaaaacagc ctaaatatta aatctaattt aatattaaat aaaatgagaa
     2761 atttaattgg ggaggataag tcaaaatgga aaatgtgtat gacttagtaa taattggttc
     2821 aggaccagca gggcttgcag caggtcttta tggagcaaga gcaaagttaa aaactctaat
     2881 cctagaaaaa gacaagactg gtggacaaat tgtaataaca catgaaattg caaattatcc
     2941 agggtcagtt ccaaatgcaa caggaccaag tttaatagct agaatggttg aacagtgtaa
     3001 agagtttgga gcagaaatgc taagagacaa cattgttgat actgagctag atggagatat
     3061 aaaagtttta aaaggggaaa aggcagaata tagagcaaaa gcagtaataa taggaacagg
     3121 agcaacacca agaaagattg gttgtcctgg agaaaaagaa cttactggta aaggggtttc
     3181 atattgtgca acttgtgatg cagatttctt tgaagatttt gaagtatttg ttgtaggtgg
     3241 aggagacagt gcattagaag aagcaatgta tttaactaaa tttgctagaa aagtaacaat
     3301 tgtacataga agacaaggat ttagatgtgc taagagtgtt gaagaaaaag caaaagctaa
     3361 tccaaagata gagtttttat tagatacagt aattgaagaa atcaaaggtg atggaatatt
     3421 agaatcagtt gtatttaaaa ataaagttac tggagaaact catgaatact ttgcagatga
     3481 agaagatgga acaatgggag tatttgtgtt cgttggatta gatgctcaaa ctgatttatt
     3541 caaaggtaaa gttgatatgg atgaaaaagg ttacataata actgatgaag atatgagaac
     3601 taacatacca ggcgtatttg cagcaggaga ttgtagatct aagactctaa gacaggttgt
     3661 aactgcaact aatgatggag caattgcatc tatagtagct gagaaataca ttgatgaaaa
     3721 atttgggaac tagaatctgt aaattaagaa atagtgtctg taaatttaat gaataatatt
     3781 taaaattaaa attaatattt aaaataaaaa taaaaatttc aagggggaat aagaaaatgt
     3841 tagatttaga taaggctaca tttgaagaag aagttttaaa tgcagaaggt tttgtatttg
     3901 ttgatttttg gagtgaaggt tgtgagcctt gtaaagcttt aatgccagat gttcataaat
     3961 tagctgagac ttatggggat aaaataaaat tctgtaagat ggatacaaca aaagctagaa
     4021 gattagctat aaaacaaaaa gtattaggtc ttccaactat ggctatatac aaagatggag
     4081 aaaaagtaga cgaagttact aaggatgatg ctacagttcc taatatagaa aacatgatta
     4141 aaaaatatct ttaatatgtt gataaattat taacattaaa agaaaaaatc tatttttatc
     4201 tgaagataag aagaaaaagg tttttatgtc caactttgtt aaaaaaataa ttttaaataa
     4261 aataattttt ttacaataaa tattttttag taataaaata aagatttaag gcataaaaac
     4321 acaataatat atctttaaaa aaataagata aattgtaaaa tgatataatt ttgagaaaaa
     4381 ctcaaatgca tatacacaaa ttaaataaca ggaggtgcaa gtatgcgtct tgaattaggg
     4441 aaaatcttta taaaagatat tcaatttggt gatgtaacag aagtaaaaga tggagtatta
     4501 ttcatcaata agcaagagat gctacaagaa attggtggag atgagcatat taaatctata
     4561 gatatagaat tagctcgtcc aggtgaaagc gtaagaataa cacctgtaaa agatgttatt
     4621 gagccaagag taaaagttga aggtaatggg ggaatcttcc ctggtatcat gtctaaagtt
     4681 gacactgtag gagaaggaaa aactcatgct ttaaaaggtg tagctgttgt aactactgga
     4741 aaaatagtag gtttccaaga aggtataata gacatgactg gagaaggagc taagtacact
     4801 ccattttcta aattaaataa tgtagtagta atagctgaac ctattgatgg tttaaaacaa
     4861 tacgctcatg aaaaagctgt tagaatgata ggattcaaag cagcaatgta cttaggagaa
     4921 gtagcaagaa atcttactcc agatgaagtt tcagtatatg aaactaaacc tcttcttgaa
     4981 tcaataaaag aatatccaga gcttccaaaa gtaggatatg tttacatgct tcagactcaa
     5041 ggtttattac atgatactta tgtatatgga gtagatgcaa aacaaatagt accaacttta
     5101 ttatatccaa cagaattaat ggacggagca attgtaagtg gtaactgtgt ttctgcatgt
     5161 gacaaaaacc caagttatgt tcatataaac aatggggttg ttgaagactt atatgcaaga
     5221 catggtaaag atataaactt tgtaggtgta attataacta atgaaaatgt ttatctagca
     5281 gataaagaaa gatcttcaaa ctggacttct aaattatgta aatatttagg attagatgca
     5341 gttatagttt cacaagaagg ttttggaaat cctgatactg accttataat gaactgtaag
     5401 aagatagaaa tgcaaggtgt taaaacagtt atagttacag atgaatatgc tggacgtgat
     5461 ggaggttctc aatcacttgc agatgcagat gtaagagctg atgctgttgt aacaggtgga
     5521 aatgccaacc aagttgtagt tcttcctaag ttagataaag ttattggaca tttagaagta
     5581 gtagatgtaa tagctggtgg ttctgatgga agtttaagag ctgatggaac tattgaagtt
     5641 gaaatccaag ctataacagg tgcaactaat gaaacaggat ttggtcattt aactgctaaa
     5701 ggatattaag aagtatttta ttaaacgatt gagtaatgtt aataaaacat attatagata
     5761 attataataa gtgttataga tatataaaaa tatattagaa atataataag gaggattatt
     5821 atgagtttac ttagtaataa aaaggttctt ataataggtg accgtgatgg tataccagga
     5881 cctgcgatag aagaatgtgt aaaaacagta gaaggagcag aggttgtttt ctcatctaca
     5941 gaatgctttg tctgaacagc tgctggggct atggacttag aaaatcaaaa cagagttaaa
     6001 gatgctgctg ataaattcgg agctgaaaat gttgtgattt tactaggtgc tgctgaagcc
     6061 gaagctgcag gtcttgcagc cgaaacagta actgctggag atccaacttt cgctggacca
     6121 cttgctggag ttgccttagg attaagtgtt taccacgttg ttgaggaacc aataaaatca
     6181 ttatttgatg aaagtgtata tgaggaccaa ataagtatga tggaaatggt tttagaagtt
     6241 gaagaaatag aagaagaaat gtctggtata agagaagaat tttgtaaatt ttaatgccta
     6301 aaagcaaaag gggtgaaact aagagatggg aaaactaaaa gcagtacatt atattaatca
     6361 gttctttgct ggtataggtg gagaagaaaa agctgatact aagccacatg tggcagaaac
     6421 tttacctcca ataagtttac aacttgataa attattaggt gaagatattg aaatagttgg
     6481 aacagtagtt tgtggagata gctatttcaa tgaaaatata gatagtgcaa gtgaagaagt
     6541 tttatcaatg gtaaaaggtt ttgaaccaca acttttcata gctggtcctg catttaatgc
     6601 tggtagatat ggggttgctg ctggaacaat aactaaagtt gtaaaagatg ctttgaatat
     6661 accagcttta acaggtatgt atgttgaaaa tccaggagca gatatgttca aaaaggatgt
     6721 ttatgtagta gaaacttctg attctgcagc aggtatgaga aaggcacttc ctaagatagc
     6781 taaacttgca gtaaaacttg ctaatggaga agaaattgga actcctaaag atgaaggata
     6841 catagctaga ggaataagag ttaactactt ccatgaagac agaggttcta agagagctgt
     6901 tgacatgtta gttaagaaaa taaaaggtga accatttgaa actgaatacc caatgccaaa
     6961 ctttgataga gttgacccaa gtaaagctgt aaaagattta tcaaaatgta aaatagcttt
     7021 agttacttct ggtggtatag ttccaaaagg aaatccagat agaatagagt cttcttcagc
     7081 ttctaaatat ggaacttatt ctatagcagg agttatggat ttaacagaag agacttatga
     7141 aactgcacat ggtggatatg acccagtgta tgcaaattta gatgcagata gagtattacc
     7201 tgttgatgtt cttagagatt tagaaaaaga aggtgtaatt ggaaaattac atgagacttt
     7261 ctatacaact gtaggtaatg gtacatctgt tgcaaactct aaaaaatatg cttctgaaat
     7321 tggagcagca ttagtggctg atggtgtaga tgcagtaata ttaacttcta catgaggtac
     7381 ttgtactcgt tgcggtgcaa cgatggtaaa agaaatagaa aaaactggac ttccagtagt
     7441 tcatatgtgt acagtagtac ctatttcatt aacagtaggg gctaatagaa tagttccaac
     7501 tatagcaata cctcatccac ttggaaatcc agcgcttgac cctacagaag aaaaagccct
     7561 aagaagaggc cttgtagaaa aagcattaaa tgctttaact acagaagtag atggtcaaac
     7621 agtatttgaa aaataaaaat aacacacaca tatattatat agataaaaat ataaacacac
     7681 actaaaaata aaaaataact atacacaaaa aaataatata gatttcatga atggataaat
     7741 tggagttatt cattcatgaa atcttaaaaa atgccaaaat acataaacaa taatagaatc
     7801 aaatatacaa taaaatacaa tgattagagc ttttaataag tttaataaga ttaaaaaata
     7861 agtgttcata aaatttatgg aggtgcacaa aatgacttat ccagttttaa aaggggcagg
     7921 ctatgtactt attcatactc cagatatgat agtgcaaaat ggaagtactt gtacagttga
     7981 aagagcaaca aatccagatt cagaattttt aaaagaagta agtaatcata taagaagtta
     8041 tgaagatgta gttaactaca tgccaaatca agtttatata ggaaatagaa gaccagaaga
     8101 attaagagat ttaccaatgc catggtgtga acaaaagatt gagggaacta gaaatggtaa
     8161 gtttggagaa ataatgcctc aagatgagtt catagcttta atgcaaataa gtgatgcatt
     8221 tgatttagta aaattatcac aagaatttat tgatgaagta aagccaaaaa tcgaaaataa
     8281 ctaccctgaa attgcaccat ttgtaggtaa attaaagggt gatgatatag aagaaggtaa
     8341 agaattagta gcaacacaca tagctgaagg attataccat gatggaaaat ttgttggtta
     8401 tgtaaaaaga gcacatgatg tagatgttaa cttaaatgcc catacaatgt ttgaaaatct
     8461 agtagtaaaa gcatctggag ttttatctgc tattcaaatg ctaagacata gcaaaataga
     8521 ccctgctgaa atagattatg ttattgagtg ttcagaagaa gcttgtggag atataaacca
     8581 aagaggtgga ggaaactttg ctaaatcaat agctgagata gcaggacttc aaaatgcaac
     8641 tggttctgac acaagaggat tttgtgcagc accaactcat gcattaattc aagcagcagc
     8701 tttagtaaaa gctggcatac ataaaaatgt aatggtagta gcaggtggag caagtgctaa
     8761 acttggaatg aatgctaaag accatgttaa aaaaggtctt cctgtacttg aagatgttgt
     8821 tggaggattt gcagtacttg tatctgaaaa tgatggtgta aatccagtta taagaactga
     8881 tttaacaggt aagcatactg ttggaactgg ttcttcacca caagcagtta tgacagcact
     8941 tataacttca ggtcttgata gagctaattt aaaaataaca gatgttgatg tgtattcagt
     9001 tgaaatgcaa aacccagata taactaagcc agcaggagca ggagatgttc cagaagcaaa
     9061 ctacaaaatg ataggggcac ttgctgttaa acgtggagac ttagaaaaga aagaattgaa
     9121 agattttgtt tctaacaaag gattaccagg atgggcacca actcaaggac atataccatc
     9181 aggagctcct tatataggat ttttaataga tgatttaact acaggaaata gaaatagagc
     9241 tatgatagtt ggaaaaggta gtttattctt aggaagaatg actaacttat ttgatggagt
     9301 atcttttata gctgaaagaa atacaggtgt tactgaagag acttcaggaa tatctaagga
     9361 tgaaattaag aagataatag ctgaatctat gaaaaaacta gcattagata tgttagaaga
     9421 ataggggtga ggatatgtca aaaaaagtaa tcgcagatgt attcttagaa gtagctaatg
     9481 caatagaaag cggcgaattt ggcaaaaaag taaaaattgg tgttactaca cttggaagtg
     9541 aacatggtgt agaaaacatg gttaatggtg cacaattagc aaaatctaat ttatttgata
     9601 ttgtgcttat tggaccaaaa gtggaaactg accttgaagt agttgaagtt aatgatgaaa
     9661 aagaaatgca tgcaaaaatg gaagaattat tagattcagg atatattgat gcttgtgtta
     9721 ctatgcatta taattttcca ataggtgtat ctacagtagg tagagtaata actccagcaa
     9781 aaggaaaaga aatgatactt gcaacaacaa caggaacaag tgctactaat agaatagagg
     9841 caatggtaag aaatgccatt tatggtattg ctacagctaa atcaatgggt aacaaatgcc
     9901 caaaagttgg aatacttaat gttgatggag caagacaagt tgagaagtgc ttaaaagaat
     9961 taaaagataa tggatatgac atggagtttg cggattcaat tagagcagat ggtggatgtg
    10021 taatgagagg taatgattta cttgtaggtg cacctgatgt tatggttact gatacattat
    10081 ctggaaatat atttatgaaa gtattttctt catatactac aggtggagat tatgaagctc
    10141 aaggctttgg atacggacct ggagttggag aggactatga tagaaaggta cttatagtat
    10201 caagagcatc aggttctccg gtagtagcaa atgctttaaa atacgcttat gatgttgtaa
    10261 agggagatat aagtaatgtt gcaagaaatg aatttgcaaa ggttaaaaaa gcaaaatttg
    10321 atgacattat atcctctctt actaaaaaag aagttaaagc tgaaaaagta gaagttaaaa
    10381 tgccagataa agaaattgtt actcgtcaaa tagctggtgt tgatataatg gatttagaag
    10441 atgcagtatc tgagttatgg aaaaacggaa tctatgctga aagtggtatg ggttgtacag
    10501 gtccaatagt tttagtaaat gaagctaaag gagacttagc agttgaaact ttagttaaag
    10561 ctggatatac tgcaaaataa gtacattttt tatatgtaaa taagaacata tagttataat
    10621 tttattgatt ataattatat gttcttttta ttttatatct tgtcaatatt tatatattaa
    10681 cacaatccat ttatttgatt ctctagctaa tttattatat ttattcagtt aaaattaagc
    10741 tttctaacta aataaaaact aatgaagtat taaaatgaaa ttgataaaat atgaaaaaat
    10801 tttaggaata aagtatctgt tagataaaaa taagattaat tagtgatata atataattaa
    10861 gataaaattt attatttgga ggcaaaatca tgagcagagt aaaaaatgta gtagaattgt
    10921 tggaaactaa aggtgttgat gcactatatc taacaaagaa aactaatgta aactatataa
    10981 gtggttttcc tgatgaagaa gcatatgcag tgatttgcaa agatggaaac tttttagtta
    11041 ctgatagtag atatatggag cttgcagaaa aggtttgcaa agattttgaa attataaatt
    11101 ggcataattt tgatagaagt gtggcaaagg cagttaaaag tgtatgtgat aaagtgggta
    11161 taaagaaact tgggtttgaa agaactaata tagtgtttga taaatatgaa gaacttaaaa
    11221 atctgattga gaaggataat ggagaattaa tacctacaga aaatattgta gagactttga
    11281 gatatgtaaa agacaaagat gaaatcaaaa atacaagaaa agcttgtgaa atagcggata
    11341 aggcattaga agaattgatt ccacatataa aagctggagt tagcgaaatt gaactggcta
    11401 caaagttaga gtactttatg aaaatgaacg gagcacaaaa tatagggttt gaaactatac
    11461 tgatatcagg agcaaagact tcattgcttc atggtaagcc tagtgataag attatagaaa
    11521 aaggtgattt tgtacttata gactatggcg ctatgtataa tggctatata tctgatacaa
    11581 ctagaacttt tatagttgga ggagcttctg aaaagcaatt agaaatatat aatttagtta
    11641 aggaagctca aaatgtaggg gttgagaaca tgaaagctgg tgtacatgcg acaattccag
    11701 atgctgagat aagaaaagtt gtcaaaaaat atgaagacta ttactatcaa ggtataggac
    11761 atggagtcgg tagagatgtt catgaagaac ctttcattgg taattatggt gataaaatca
    11821 tagaagaggg atgtataata acaatggaac caggtattta tttccctgga tggggtggag
    11881 ttagaataga agatactgtt ttgattacta aaaatggtcc agaaagactt actaaattcc
    11941 ctaaagattt gatgatttta gacaaataat ttaatttata tatatttttt tacataaaat
    12001 ataacataat ctcactatta agctctattt acatattata gtaaagaggg cttaatttta
    12061 ttgtgagagg tgatagtata tatgtataaa aaacataaat ttataaaaaa tataaaaaaa
    12121 gcctggtata aaatcaaatt aattgataga tgccttataa ttgtaatggc aatattaatg
    12181 tttcaatcta tatataattt atttgttaat gaagtaaatt cacaagatac tacaactatt
    12241 gatgtagtag taagaaccac ttcagcagct atatttgggt attttttaag tgctaatttt
    12301 ataaagagac ctttaaggaa gtatacaaat actgatgtat cttcaaatct ttttatagat
    12361 aataatttat ccccaaaagg tcaagagtct aatcaaaata atataatgaa tgtcaaaaat
    12421 accattggat ttacttcaga agctgataat tatgaaaaga aaatacctat taataataat
    12481 gaaggttttg aagaaggaga aactagtgaa ttgcaaatta ttatagctac tgtaatttgt
    12541 atagtagcat taacagtact ttttgttgta agaaatttta caactacaac atcagcttct
    12601 ttaggtacta tttcacagat gagagatttt gtctcaggat gcgtgggttt tttgctaggt
    12661 tgtccaagta aacctgatta aaaaagtatt atcaataaaa ggtattttaa aaagtatcag
    12721 tataataata tttagattta aatgtataca attataattc taaacattct atattgtatt
    12781 tttatactga tactctaaac tatactattt attaaaatat tttaacattg tatttaaaca
    12841 aaatattata tctgtataat ataaatttag tttatatgaa tagatgccat atactcaata
    12901 aaaagtttca tactatgaga tatgtattga tttcttctcc aaagaacccc aatattcgca
    12961 gtaattgcac gttctaatgg tattgaacag agattttctg tattttgaaa tatttcttta
    13021 tacaatattg ttgaagccaa gtcattttct agtaaataac gtatggtaga aagttgattt
    13081 gagtgtaaaa ttatatttgg cttagctttt tcaagtcttt ttgtaataat cttatagtga
    13141 taagaacctt cagataagat tacaaaaggt acatttttta acatataatt cgatataatg
    13201 ggatgttttg ccaattcatt tttgggattt gtaactaagt ataattctgt tttatagatt
    13261 gtctttgaat ctatatcatc ataaatatca ctgtcaatta taccaataca aaaatcaagt
    13321 gtagattctt caatcatttt agctccaaca aatgttggaa cttcaaaaat tttaagctct
    13381 atatctggat aaattacatt aaatctagga agtatttttg aaagcaaaaa cgtacctaaa
    13441 actgtaggaa tacctatttt gagagaagct tttctctttt ttcctaaatc aagtgcgtca
    13501 cattgaaaat cctcaaattg ttttataaaa tgttttgact tgtctaaaaa aatttttcct
    13561 tcaggcgtta actctatttt attacctatt ctgtaaaaaa gttcaaagcc aagttctttt
    13621 tctaattctt taattgctaa tgttatggat ggttgagaaa tatgaatact ttccgcagcc
    13681 ttagtcatgt ttttatattt acagacagtt tgaaaatagt ataaatagtt tatattcatt
    13741 tggtattagt tcctttcatt tacatattag tgacaagtat ataattaaca atagcataag
    13801 ttttgtatat tgttgtaaaa aaatagaata gttttaaact atcatagcat aagtttttga
    13861 tattttcaat ctattaagaa tagtgctatt attaaattaa caaaagagaa tagctggtat
    13921 ggtttagagt aaatcaatct atattacagt tatatcaacg aatatcaaaa aattatctat
    13981 tagaaaataa aaattatttt tacaattaaa ttgttaatta aatcataaag aaaaaagtga
    14041 tattaacaag ataaaatttt tttaatcaga aatgttaatt taataacaaa atagagtatt
    14101 ggggagaaag gagaaatata ttttttaata atatttgtta atttaataac gaaaaatgaa
    14161 agggagtgat ttagtgaagt ttgaattgat ggatttttta atgaatcctt ttgtccttat
    14221 gtttgctgca gtaattacag gaattttatt tggaaaaatt aaatttggga agtttaattt
    14281 tggggtatca ggagcattat ttacaggatt atttattgga tggcttgcat atagcttggg
    14341 gaatctaata atagcaaaag gggaaacagc agcaggatat aaggcagcaa ctgtaatgat
    14401 gggtaatgga attatttctt ctgacttctt tgatttcttt ttaataatat ttgttgcagc
    14461 agttggtcta ttggcagcaa aagatatgaa agctgtatta aagaagtatg gagcaagatt
    14521 tgtaatttta ggagttctta taacttttat aggtggctct atgacttatg caatgacttt
    14581 actatcaagt gataaaggaa gtagtgctta tgaagtttct ggcgtttaca caggagcatt
    14641 aacaagttcg cctggattag ctgctgcttt agaaacagct ggtaaacatg cagaagatgt
    14701 atcaaaagaa tttgaaaaag cttcaataaa agataaaaaa gaaattttaa aagtagtcga
    14761 cccagaaggc aaattggatg tgaatacaac tacatcactg actcaagagc aaatagataa
    14821 gtatattgca tatgctgaag ctggtgttgg tataggtcat gcagtcgcat atccttttgg
    14881 agttttaata gtaatcttag gtgtaaattt ccttccaaaa ttatttagga tggacctaaa
    14941 agaagaaaga agaaaatatg agaaggaaat gaaggaagca agagatagtg tttctggtaa
    15001 aacgatacca gaagttccat ttaatataat aacatttttc ttgacatgtt tagctggata
    15061 cttagttgga ggaatacatg tatttatggg accactaggg tacttcacac taggtgcaac
    15121 aggaggttca ctaattgtat ctctagttct tggatatata ggtaagatag gggtagtaaa
    15181 tttcagaatg gaagaaaagg ttttaaatat tttaaaacaa atagggctag tatttttctt
    15241 agcaatagtt ggattaagat atggtggaaa agtagttgat tcaattatga catctggtat
    15301 gcacctagcc ttagtagcaa tagcagtagg tgttacagct atgatgatag gattcttagt
    15361 tggcaaatac gtatttaaat taaattggat tttattatct ggagctgtct gtggtggtat
    15421 gacatcaaca ccaggtcttg gagctgctgt tgatgctctt gatagtgatg acccagcagc
    15481 aggttatggt gctacgtatc catttgcatt attaactaaa gttatattgg ttatagtttt
    15541 acacaaactt ccaatgtaaa taagatttta tatgggggga tatttatgaa taatgaagga
    15601 gcatttgaag aattaagtgg aagattaaga aataaagaat tgtgtgattt aataatgaat
    15661 gcagatgaag ctgctaaaat tatagaggat ggcatggtta ttggagttag tggatttaca
    15721 ccttcaggct atccaaaagc agtaccatta gcagtttcag aaagagctaa aagtggagaa
    15781 aagataaaat taaccgtata ttcaggagca tctttaggtc cagaagttga tggagcatgg
    15841 tcagaagcag gtataattga aagaagactt ccttatcaaa ctaattcaat acttagaaat
    15901 aatattaata aaggtgttgt tgattatata gatatgcacc taagtcattc tactcaattt
    15961 ttaaattatg gaactatacc taaagtagat gtagctatag tagaagcact tgcaataact
    16021 gaagaaggaa atattatacc aactagtggg ataggtaatt ctccatcttt tataaaaagt
    16081 gcagataaag taatagtaga gataaatctt gcaaaaccaa tggaaatgga aggtatggca
    16141 gatatatata ttacggaaaa tccaccaaat agaaaaccaa tagaaataaa tcatcctaag
    16201 gatagaattg gaacaacata tataccttgt ggtttggata aaattgcagg agtagtaatt
    16261 accaatatgc aagataagac ccgtccattg ggagttgtag atgaagcttc gaaaaaaata
    16321 tcaaataata ttattgcttt tttaagagaa gaagtaaagg caggcagatt atcaaagaat
    16381 ttacttcctc ttcaatctgg tgtaggaagt gtagcaaatg cagtattata tggattatgt
    16441 gaatctgaat ttgaaaattt aacttgttat acagaggttg tacaggactc tatgttggat
    16501 ttaataagaa tgggtaaagt tacaatggca tctactacat ctgtaagtcc atctccagaa
    16561 ggattaataa aatttgaaaa agatattgat ttttttaagg ataagattat attaagacct
    16621 caagaaatta gtaacaatcc agaaatagcc agaagaattg gtgtaattgc aatgaacact
    16681 gcaattgaag ttgatattta tggaaatgta aattctactc acataatggg gtcaaagatg
    16741 atgaatggaa ttggtggttc tggtgatttt gctagaaatg gagcaataac tatatttagt
    16801 actgagtcaa ttgcaaaaaa tggtgatata tcatcaatag tacctatggt atctcacgta
    16861 gaccacactg aacatgatgt aatggtaatt gtaacagaac aaggatatgc tgatttaaga
    16921 ggtcttgcac ctagagaaag agctataaaa ataatagaaa attgtgccca tccagattat
    16981 aaagaacaac ttagggatta tttaaataga gcttgtaaaa gtggagcaaa acaaacacct
    17041 cacatattgg acgaagcttt atcatggcat agtaaattta tgagtacagg tacaatgaaa
    17101 aaggctgaaa cttttaaaag tgcattataa aatatttaat aaattggagg tagattttaa
    17161 atggaaaaag cagtggaaaa ctttgaagat ttaagtaagg aatacattaa tggttatatt
    17221 gagagagcaa gaaaagctca aagagagttt gaatgttata ctcaagaaca agtagataaa
    17281 atagtaaaaa tagttggaaa agtagtgtat tataatgctg aatatttagc taaacttgct
    17341 gtagaagaga ctggaatggg agtatatgaa gataaggtag ctaaaaataa aagcaaagca
    17401 aaagttatat ataacaattt aaaagataaa aaatcagttg gtataattga tatagataga
    17461 gaaactggaa taacaaaggt agctaaacca gttggagtag tagcggcaat aactccttgt
    17521 acaaatccaa tcgttacacc tatgagcaat gcaatgtttg cacttaaggg aagaaatgca
    17581 attattatca cacctcatca taaagcaatt ggatgtagta caaaaactgt agagatgatt
    17641 aatgaagaat tagaaaaaat aggagctcca gaaaatttaa tacaaatact tgaccaacaa
    17701 tcaagagaaa atacaagaaa tttaatttca tcagcagatg tagtaattgc cactggagga
    17761 atgggaatgg taaaagctgc gtactcaagt ggaaaaccag cacttggtgt aggggcagga
    17821 aatgttcaat gtatcataga tagagatgta gacattaaag aagcagtacc taaaatcata
    17881 gcaggaagaa tttttgataa tggtatcatt tgttcaggtg aacagtcagt aatagtagca
    17941 gaagaaatgt ttgataaaat aatggatgaa tttaaaaata ataaaggttt tatagttaga
    18001 gataaagtac aaaaagaagc tttcagaaat gctatgtttg taaataaatc tatgaataaa
    18061 gatgcagtag gtcaatcagt tcatacaatt gcaaaaattg caggtgttga gataccagaa
    18121 gatacaaaaa taatagtaat agaagctgat ggaccaggag aagaggatat tattgcaaaa
    18181 gaaaaaatgt gtccagttat atctgcatac aagtataaaa gttttgaaga aggtgtagct
    18241 attgcaaaag caaatttaaa tgtagaagga aaaggacata gtgtatctat acattcaaat
    18301 acagttaaaa atatagaata tgcaggagaa aatatagaag tatcaagatt tgttattaat
    18361 caatgttgtg ctactagtgc tggaggaagt ttctttaatg gtcttgcacc tactaatact
    18421 ctaggttgtg gttcttgggg aaataacagc atctctgaaa atcttgatta taagcatcta
    18481 attaatattt ctagaattgc ttattatatg ccagaaaatg aagtccctac agatgaagaa
    18541 ctttggggat aaaatttaga caaaaaatat tcattctaaa ttaaagtagg aatatatttt
    18601 aatttagaat gaatttaaga cataaattaa atttaaatta gtttattgga ctaaatttaa
    18661 aatattaaga gacatataga agaaggaagt attataattt aaaataaata aaaaaatcta
    18721 taaaagagaa ggagtggttt tattatggca ttaatgacag gagctcaata tattgaaagt
    18781 ttgagaaaat taaatactaa ggtttatatg tttggtgaag aggttaagaa ttgggttgac
    18841 catcctatga ttagaccatc tataaattgt gtagcagcaa cttatgactt agctcatgac
    18901 ccagaatatg cagatttaat gacagttact tcaaatatca caggtgaaaa aataaataga
    18961 tttggtcatc ttcatcaaag tgttgatgat ttgataaaaa aagtaaaaat gcaaagacta
    19021 tgtggtcaaa aaacagcttc ttgtttccaa agatgtgttg gtatggatgc gtttaatgca
    19081 gtgtattcaa caacatttga gtgtgataaa gcccatggaa ctaattatca tgataatttt
    19141 gtaaaatact taacttatat acaagaaaac gatttagtag ttgatggagc tatgactgac
    19201 cctaagggag atagaagtct atcacctagt gctcaacctg acccagatat gttccttcat
    19261 atagtagaaa gaagagaaga tgggataatt gtaagaggag caaaggcaca tcaaactggt
    19321 tcaataaatt cacatgagca ccttataatg cctactataa gtatgactga agcagataaa
    19381 gactacgctg tatcatttgc agttccttca gatgctgaag gagtgtttat gatttatgga
    19441 agacaatctt gtgacactag aaaattagaa gaaggtgcag atgttgattt aggaaataag
    19501 gagtttggag gtcaagaagc tttagtagta tttgataatg tatttgttcc aaatgataga
    19561 attttcttat gtggagaatg ggatttctct ggtatgttag tagagagatt tgcaggatac
    19621 catagacaaa gttatggtgg atgtaaagta ggagtaggtg atgtaataat aggagcagca
    19681 gctttagcag ctgattataa tggagcaaac aaagcttcac atataaaaga taaactaata
    19741 gaaatgactc accttaatga aagcttatat tgctgtggta tagcatgttc atcagaaggt
    19801 cacaaaacag aagctggaaa ctatcaaata gatttacttc ttgcaaatgt gtgtaaacaa
    19861 aatgtaacta gatttcctta tgaaatagta agacttgcag aagatatagc tggagggctt
    19921 atggttacta tgccttcaga aaaagacttt aaatcagacc ttaaagttgg aacaagtgga
    19981 atgactattg gcgaagtatg taacaagtat tttaaagctt cttcagtggc ttcaacagaa
    20041 gaaagaatga gaatattaag attcttagaa aatatatgcc ttggttcatc tgctgttggt
    20101 tatagaactg agtcaatgca tggggcaggt tcaccacaag ctcaaagaat aatgatttca
    20161 agacaaggaa acataaatca aaagaaagaa ttagctaaga aaattgcggg aataaaaaaa
    20221 gaggaagctt taaatttata aaaagttgat atataaaggg aaattatata ttaatgtgta
    20281 ttaattaatg aaaaaatatg tagtataaga gatagttata aaattatggt ggtttttagc
    20341 taagtaaaga aatttttaat aaggagaatt tacacatgac ctgtggagtt agattttgtg
    20401 ggggctgtaa ccctagatac gaaagaggga aggctcttac aataatcaaa gagcacttca
    20461 atggtagggt agattttagt atagcacaag agaacgtcga gtatgatttg ctacttataa
    20521 ttggaggatg cgcaactcta tgcgcatcct atcaacaata taaagtgaaa aatgaatgtg
    20581 ttaagatgtg ggattttagc catatagaaa gagttataaa tgtgattgaa tcagcaattt
    20641 gtgaaactta aaaaagctaa atggggggat ttcattgagt tggcaagaat tgtatcaaag
    20701 taaattatgt agtgctacag aagctgtaaa acagattaaa aacggtgata ctgtagtatt
    20761 tgcacattgt gtaggtgaac ctcctgcact agtagaggct atgattgaaa atgctgaaca
    20821 atataaagat gttgagatta aacatatggt aagcttgggt agtggtggat atactgctaa
    20881 gggaatggaa gctcatttta gagtaaatcc aatgtttgta agtggaaatg taagaaaggc
    20941 aattgaaaat ggagatggtg attttacacc tgcattcttc catgaagtac caaagttgct
    21001 tagagaaaaa agattaaaat gtgatgttgt tttagcacag gtaactccac cagatgaaca
    21061 tgggtattgt agcttaggaa catcagttga ttatacttat gaagccatta aaactgctag
    21121 aacagtaatt gttcaagtga atgaccagtt tcctagaacc tatggtgagg tagtccatgt
    21181 atcagagttt gactatatag tggaaaaatc acaaccttta tttgaactac aacctgcaaa
    21241 gattggagaa gtagaagaag caattggtaa aaattgtgct tcattaattg aagatggttc
    21301 tactttacag ctagggattg gtgggatacc agatgcagtt atgttatttt taactgataa
    21361 aaaggattta gggattcatt cagaaatgat ttcagatggg actttggccc tttatgaaaa
    21421 aggtgttata aatggtaaat ataaaaattt tgataaagaa aaaatgacag ttaccttctt
    21481 aatgggtact aaaaaattat atgactttgc aaataataac cctgcagtag aggtaaaacc
    21541 agtagactat gtgaatcatc cagcaattat aatgaaacaa cataagatgg tttctataaa
    21601 ttctgctata caagttgatt taatgggaca ggtagttgca gaggctatgg gacttagaca
    21661 atttagtggt gttggaggtc aagttgactt tatacgtgga gtgtctatgg gtgaagatgg
    21721 aaaggcaatt atagctatgc cttcaataac tacgaaaaaa gatggtacag taatttcaaa
    21781 aatcgtgtct attgtggatg aaggtgcacc tataacgaca tcaagaaatg atgttgacta
    21841 tattgtaaca gaatacggta tagcagaatt aaaaggaaaa tctcttagag aaagagcgag
    21901 aaatttaata aatatagctc atccaagtgt aagagaaagt ctagcagtag aatttgaaaa
    21961 gagatttaag gagaaatatt aataatagag gggtgttaat aatggaagca cttagagtag
    22021 ttccaaagat attttacttt gatacattta aagaatttaa tgaagaattt aaaataggaa
    22081 aaaatgattt agtaattact aatgagttta tatatgagcc atatatgaaa cctcttggaa
    22141 tagatacaaa tttaattttt caagaaaagt ttggaacagg tgaaccatct gatgaaatga
    22201 tagactccat gacaaaggaa atgaagaaat acaattttga tagaattatt gcatttggag
    22261 gaggaacaat agttgatata tgtaagatat tagcacttga tgttccagaa aagtctattg
    22321 atttatttga aggagaagta tcacctaaaa aagtaaaaga gttagtagta gttcctacaa
    22381 catgtggtac aggtagtgaa gtaacaaatg tagctattgc agagttaaaa tctaaacata
    22441 ctaaaaaggg gcttgcagta gaagaaacat atgcagacta tgcagtgtta attccagaga
    22501 cagtaaaagg gttaccttac aaattctttg ttacaagttc ggtagatgct cttatacatg
    22561 ctattgagtc ttatctttct ccaaaagcaa gtccatttac agagatgtat tctctacaag
    22621 caataaaaat gattatggat gggtataaga agatagttga taaaggagaa gaagagagat
    22681 ttaatcatct tagagacttt gtacttgcat caaattatgc aggaattgct tttggaaatg
    22741 ctggttgtgc agcagttcat gcactatctt attcaatagg tggagctttc catgttgcac
    22801 atggtgaagc aaattatcag ttctttactg aagtatttaa gatgtattct agaaaaaaac
    22861 ctaatggaaa aattataaaa tgtacaaaaa ttttagcaga tgcccttgaa tgtgacccta
    22921 actgtgatgt ttatggagaa ttagaaaagt ttttaaataa attaatagct aaaaaagctt
    22981 tgagagaata tggaatggtg gaaagtcaga tagatgaatt tacagatagt acaatagcaa
    23041 atcaacaacg actacttgct aataattatg tagagcttag tagagaggaa ataagagaga
    23101 tatttgcaaa tctttattaa tacaattttt tatttatatg tatagtcaac ataaacaatg
    23161 ctaattatat ttatgtacaa ataaaaataa gggaacttaa attttaatta aagttaagtt
    23221 ctcttatttt tatatggagt taaatataag tatattttta atttaaaata tgcttatatt
    23281 taagtctatt actttatttg aaacaatttg tagaatttca aattccttga cagtaataag
    23341 taagtaattg tataatcaaa ctgcaatata ttaataatat tagtgaaaat gaaaggatta
    23401 taaaatatgt ataaatcaga aaatttttca aaaaaatctg tattaataaa ttcattttta
    23461 agtaaatttt taaaaataat tggatggggt ttggtaagct tatttacatt atcagcctta
    23521 gtactttcaa ctatttccat tataattgga tgggctgtaa tacttcctat tcaagtatgt
    23581 gcagtatttt tacttatagg aggagtttgt atttttaaag gtaagagatt aggagaccaa
    23641 atttctcgtt ataaaaaata ttgtacaatt ataaacaata gaaatattat tccagtagaa
    23701 cttattgcag aaaacacatc taaatcatta aattttataa taaaagatgt acaaaagatg
    23761 atagacaaaa actactttat aaatacttat attgataaaa gaaataatca gattgtgtta
    23821 acaaatgaag attttgttcc accaagatat gaagatgtag catatgaagt caaagaagaa
    23881 gaaaagactg atgaatccaa tgaagttgat acaattataa ataaaggaat gaattatcta
    23941 acacaaataa aagaagctaa taaaaatatt aaatcagaat caatgggcga taaaattgta
    24001 caagtagaag atgttacaag taaaatattt gatgttgtaa aacatgaccc atcaaaactt
    24061 actcagatac aaaaatttat ggattattat cttccaacca ctttaaaact attaaattca
    24121 tatcatacat tggaagaaca aggaattgat agagaaaata taacaacaac tatggaaagt
    24181 attgaaaata caatgaatac gattgtagta gcttttgaaa atcaattgga ctatctgttt
    24241 gaagatgaag ccattgatat ttctacagat attactgttt tagagaatat gttagtccaa
    24301 gaaggattaa cgagtggtaa attttaactt caatagaaaa aatattctgt tatttttaaa
    24361 caattaatta gtcataaagt ataaaatgtg tattatataa gttaatcagt actttatgaa
    24421 ggaagaggag agaaagatac aatgaataat ttagatgata taccagttat gccaactttg
    24481 acacttgacc catttggaga agaatcaaac actaatgata tagataattc tgacttatta
    24541 atgaaaaagg atgaaaaaga cccagaagaa gaaaaactgt ctgaatctga acgcaagatg
    24601 gtaaaggaat ttgcggaaaa aatagatatt acaaatacaa atatgatttt gcaatatgga
    24661 gctggagctc aaaaaaaggt agcaagtttt tctgaaacag ctttaaagag tgtaaaaaca
    24721 agagatttag gagaagttgg agatatgctt acaaatctag ttactgattt aaaagcattt
    24781 tcagcagatg aaaaagaaca aagtggtttt ttaggaattt ttaaaaaggc aaataataaa
    24841 atttcaaatt taaaaactaa gtatgatagt gcagaggtaa atgtggataa agtaagcaaa
    24901 gagcttcaaa agcatcaggt taaaatattg aaagatatag caatgcttga taagatgtat
    24961 gaattgaact tagcttactc aaaagagctt actatgtata ttatagcagg aaaacaaaaa
    25021 ttaaaggata tgaaagaata tgaaatgcca aagttgagag aaaaagctcg tttatctggt
    25081 tcaacagaag atgctcaatc tgtaaatgat atggtttcac tttgtgacag atttgaaaag
    25141 aagattcatg acttagaatt aactagaatg gtatcgcttc aaatggctcc tcagataaga
    25201 ttggttcaaa atagtaataa tctgatggca gaaaagattc aatcaactat agtaaatacc
    25261 attccattat ggaaaaatca aatagtgctt gctcttggaa tttctcactt aaatcaagct
    25321 atgaaagcac agcgtgaagt tagtaatatg acaaatgagc ttttattaaa gaatgcagaa
    25381 actttgaaga tgggaacaat agaaacagca aaagaatcag aaagaggaat tgtagatata
    25441 gacacaatta agaaaactaa tcaatctcta atatctacta ttgatgaggt agttaaaata
    25501 caacatgatg gtagaataaa gagacaagaa gcagaagttg aattatcaaa aatagaaaat
    25561 gaacttaaaa gtaagcttct tgaatttaca gttaaataaa aattatacta atataaaaag
    25621 agactgtctc aaaatagaga taagtctctt tttcattgtt taaatgatta aagtatattt
    25681 atattataaa tttctattat cttttaacat aacatcatga gctccacctt caactatact
    25741 agtagaagat acaagtgtaa gtttagcatt tttttgaagt tcaggaatgc taagtgctcc
    25801 acagttacac atagtagaac gaactttact taaagaaaga gttacattgt ctttcaaaga
    25861 accagcataa ggcacataag agtcaacacc ttcttcaaaa gaaagtttct tatctccacc
    25921 aaggtcatat ctttgccagt ttctagcacg agcagaacct tctccccaat actctttcat
    25981 ataactacca tttatattaa ctttgttagt tggactctca tcaaaacgag agaagtatct
    26041 accaagcatt ataaaatctg cacccatagc taaagctaaa gttatatgat ggtcataaac
    26101 gataccacca tcagagcaaa ttggaatata aatacctgtt ttttcaaagt attcgtctct
    26161 agcttgagca acttcaatta tagaagtagc ttgtccacgt cctatacctt tttgttcacg
    26221 agttatacat atagaaccac caccaatacc aactttaacg aagtcagcac cagcttcagc
    26281 taggtaaagg aatccttcgc ggtcaactac atttccagct cctaccttaa ctgtatcacc
    26341 atatttttca cgaatgaaat caagtgttat tttttgccac tcagaaaaac cttctgaaga
    26401 atctatacat aaaacatcag caccagcttc aactaaagca ggaacacgtt cagcaaagtc
    26461 tctagtatta ataccagctc caactacata tctcttagaa gaatctaaaa gttcaagtgg
    26521 attttcttta tgagaagagt aatctttacg gaataccata tacataagat taccattatc
    26581 atcaagtaca ggaagagaat taagtttgtg gtcccatata atattgtttg cttcctttaa
    26641 agtaacatct ttgttagcat aaactataga tgacatagga gtcataaatt cactaacttt
    26701 agtatctaaa tccatacgac ttatacgata atcacgactt gcaacaatac ccaataattt
    26761 accagttgaa gttccatctt cagtaacagc tactgtagaa tgtccagttt tttcttttaa
    26821 gtcaagtatg tcttttaatg tgttatcagg tttaatattt gaatcactta caacaaaacc
    26881 agctttgtgg gatttaacac gtgctaccat agcagcttca ttttcaatag tttgagaacc
    26941 gtatataaat gaaataccac cttctttagc aagtgcaata gccattttgt catcagaaac
    27001 agattgcata atagcagaag tcaaaggtat attcatataa atatctgctt cctcgccctt
    27061 tttaaattta gtaacaggtg tttttaaact tacattagca ggtatacaat cagtagaaga
    27121 gaaacctggt acaagaaggt attcactgaa agtatgtgat ggtgtatcaa aataaaacgc
    27181 cattttttaa tcactcctta tatttttata ctttttataa ttgatagtat taattataac
    27241 ttattcttta attttattaa agtattttgt caaatattga gatttttgaa aaatttaaac
    27301 tattttaatt aaatttgttt aatatatatt gccttatagg gtaaagttgt atattaaata
    27361 atgtttagtg tttaatagta gctaatttaa aattaatctt t
//
LOCUS       DAEQCW010000045        26495 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.045, whole genome shotgun sequence.
ACCESSION   DAEQCW010000045 DAEQCW010000000
VERSION     DAEQCW010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26495)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26495)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26495
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.045"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            132..899
                     /locus_tag="KRO40_001948"
     CDS             132..899
                     /locus_tag="KRO40_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003722224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092768.1"
                     /translation="MEEILSVENIKKEYGRKGSKHEALRGITFKVYKGEFVGIMGSSG
                     AGKSTLLNIISTIDLPSSGDIYINGKNTIKMKQNELADFRRDNLGFVFQDSNLLDTLT
                     IKENIMLPLSLKNERVSVIENRIKEISKELNIESILDKYPGEVSGGQKQRGAVCRAIA
                     TKPSLVLADEPTGALDSKSARDLLNCLLKLNKDSNKTILMVTHDAISASFCNRILFIK
                     DGIIFTEIVKGESNREFYNKIVNTVSLIGGVNKNDFI"
     gene            886..2823
                     /locus_tag="KRO40_001949"
     CDS             886..2823
                     /locus_tag="KRO40_001949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092769.1"
                     /translation="MTLFRIAMQNVKNSFFNYLMYFISIVFSVFVFFSFKSIEYNEAL
                     SSLGEKTRMSINTSSIVIVVFVFLFIYYSNSFFFNRRRREVGTYSLLGMRKNQIGKIF
                     LYETFLMGIVAILIGIFLGLLFSKLMTMMLVKLMNEMIVVNMNLSIKALVQTLAVFLI
                     IFIVIGIRNTIVIRNKRIIELFNKYPEKYKFKKFIKLKCVLGVLLIAISYLMSISYFI
                     AENIMLSVFILVTIIPGTFLFFSSTMYMIIDAVKKRKSFYYKGQNLIAFSELGFKLKS
                     NSSVLAVIAILIATSVTMLGFTISLYYDIDRNISENYKYSYTINLGNSYVNNEIDKLL
                     YKYKKDNKIIFDKTIELIDKDINIEMYYKNGNSYIEDRTSVDIIRESDFKKLRQYQNN
                     NYEELTSKESVYYVSDSYKKIFFKDFEIEKINLHIKDANEYDINLFKVQKSILEPEIN
                     SQATFDLIVVKDDVFNQLKLHGNSRLIRLIDIKNEKKELDLTLKLKNIVSENMKFTYP
                     FNFTSSIESYNNLIKLSGLMLFIGIFLSVVFLLCTGSIILFKQLSNIYDDKERYIMLI
                     KLGANNKDIEKIISKQLKVIFLMPLVVGTVHNLFAMSIAQKFIPRSLLVPIIITLVIY
                     FIGYFIYYFLTLKYALNMIKE"
     gene            3048..4661
                     /gene="ggt"
                     /locus_tag="KRO40_001950"
     CDS             3048..4661
                     /gene="ggt"
                     /locus_tag="KRO40_001950"
                     /EC_number="2.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyltransferase"
                     /protein_id="HBH2092770.1"
                     /translation="MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGN
                     AVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEKRLYGLNSSGFAPENMELKNYNN
                     MKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
                     KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYR
                     GRLADKIDEYSKKFNGAIRKSDLECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMA
                     LNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMKVKIQELLSQEYAKK
                     RSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIA
                     LHSRGNNFNLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQV
                     LTNMIDFGLNPQEALDAPRWQWIKGKEIEVEPEMPKHIIDSLIEKGHEIKVIHDTVDM
                     GRGQIIFKTEQESYICGTESRCDGHIAVY"
     gene            complement(4794..5645)
                     /locus_tag="KRO40_001951"
     CDS             complement(4794..5645)
                     /locus_tag="KRO40_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase"
                     /protein_id="HBH2092771.1"
                     /translation="MKNIISAKELISKLEKNDNLVVIDCRFDLINRTYGIDSYKKGHI
                     KGSFILDIDKDLSSPTKEHGGKNPLQDPLILKEKLEKMGVDNDTTIVTYDDGDLNGAC
                     RLFFQLKHLGLKNVYVLDGGITSFVKEGGELEEKVNIPSCTGKEIRPNINNDLVVPME
                     YVKSKLYKKDTVIIDCRANERYQGLVEPAYSKAGHIPSAKNYFCKDLIKSDFENGSLK
                     DIEFLKKFFKDLNNYDEVILSCGSGISACVNSLALRELDIPHKIYIGSFSDWISYDDN
                     EIKTGQE"
     gene            6271..7164
                     /locus_tag="KRO40_001952"
     CDS             6271..7164
                     /locus_tag="KRO40_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfide/dihydroorotate dehydrogenase-like
                     FAD/NAD-binding protein"
                     /protein_id="HBH2092772.1"
                     /translation="MSNKIVSKRQLTDSIYLMEIEAPRVAKSSQPGQFIIIKNDEKGE
                     RIPLTIADYDREKGTVTIVFQTVGASTKKLAMFEENDFVMDFVGPLGQASEFIHEDIE
                     ELRNKKILFVAGGVGSAPVYPQVKWFKEHGLDVDVIIGARTKELIILEDDMKKVAKNV
                     YVSTDDGTYGFNGRVTDLLKDLVDNQGKKYDQAIVIGPMIMMKFMCQLTKELNIPTIV
                     SLNTIMIDGTGMCGGCRVSVGNETKFACVDGPEFDGHLVDFDQAMRRQSMYKTQEGRA
                     MLKLEEGDSHHHSNCGCGGNK"
     gene            7164..8558
                     /gene="gltA"
                     /locus_tag="KRO40_001953"
     CDS             7164..8558
                     /gene="gltA"
                     /locus_tag="KRO40_001953"
                     /EC_number="1.4.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent glutamate synthase"
                     /protein_id="HBH2092773.1"
                     /translation="MDAKKVKVPVREQEPAVRATNFDEVCLGYNKEEAMAEANRCLAC
                     KKPKCVGGCPVGIDIPGFITKIKEDDIEGAAKVIAKSSSLPAVCGRVCPQESQCEGVC
                     ILGIKSDAVSIGKLERFVADWSKENDINLSDTEPKKNQKVAVIGSGPAGLACAGDLAK
                     KGYDVTIFEAMHEPGGVLTYGIPEFRLPKQAVVQPEIDNIRKLGVKIETNVIVGKTIT
                     VDELIEDEGFEAIFIGSGAGLPMFMNIPGENANGVFSANEFLTRVNLMKAYRDDYDTP
                     ISSGKKVAVVGGGNVAMDAARTALRLGSESYIVYRRSEKELPARAEEVHHAKEEGIIF
                     NTLTNPKEILVDENGYVKGMVCIRMELGEPDDSGRRRPIEIEGSEFVLDVDTVIMSLG
                     TSPNPLISSTTKSLDINKKRCLITDENGQTSKEGVFAGGDAVTGAATVISAMGAGKTA
                     AASIDEYLKAKVNA"
     gene            8924..11143
                     /locus_tag="KRO40_001954"
     CDS             8924..11143
                     /locus_tag="KRO40_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2092774.1"
                     /translation="MKKREKVFDGLVFKHILILLILLVLIDLTSTIIYASNSMEITSR
                     NMIEASKRELENYLEVNISLLKALSQDDRFSNGETSLIEKGKLLSPYQKEYNLFMIGI
                     TDTKGNASSTYRENVNSIKDKPSFEKAIKTKQVVVSDIEVSNVTGDKVFIIYVPIVKN
                     NEMIGTIFASFYFQDVNNLISRSNFDDSIKFLMIDKDYTIISHPNKKYVNDKSKMLDL
                     EGNIIGTTKSEILKNINKKCQGDFLSWDNWRLYNVKYTNIKWTNWTLVSKCNIFKNFK
                     NLIVNFMIKLYFYIVIFMILWKLSNAKLIEQLKKLAYYDSLSGIKNKEKFRKDSMYIL
                     KNYYQDNFYLVQLDVNKFKYINEMFGYAEGNKILIHISQVLNNNTNKYEICARMDNDH
                     FILLIACNTEDELLNRLSKINKEICNLNTTNSSKYKIVMSSGIYKITKKDDIKKIDLL
                     IDRANIAAKSKKEKYEHSYSFFNEDTRNRLYKEKRLEDNMNKALEKGEFIVYYQPKYS
                     LDDVNEIEGAEALIRWNSPEFGFISPIDFVPLFEKNGFIVNIDMFVFEEVCKTLNKWI
                     NKGYTPVPISVNMSRVHLYRDNFIENITDLISKYNISPEFIELELTESVVFDNLNILI
                     DIMKKIKEIGFLISMDDFGSGYSSLNLLKDLSFDILKLDRGFLIETTDTKRGKIIISK
                     IVEMAKAIDIKVICEGVETYEQVEFLKEIGCDKVQGYLFAKPMVLDEFEKHLNFKFD"
     gene            11290..12036
                     /locus_tag="KRO40_001955"
     CDS             11290..12036
                     /locus_tag="KRO40_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092775.1"
                     /translation="MNILSIRNISKTYCGNIPFKALDKVSLNIEKGEFVSVMGPSGSG
                     KSTLLNIISTVDRQSEGEVVLDGYDVSKLKGEKLAEFRRKQLGFVFQDFNLIDTLTVG
                     ENIMLPLTLEGASIKDMNIQTKSISKFLGIDKILDRKTYEISGGQAQRCAIARAIINK
                     PAILLADEPTGNLDSKSTDDVLKLFTRINKEQKVTTLMVTHEAYSASYSDRVIFIKDG
                     CIYTEIKKSESSNSFYSDILAVLSQIGGVR"
     gene            12036..13916
                     /locus_tag="KRO40_001956"
     CDS             12036..13916
                     /locus_tag="KRO40_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092776.1"
                     /translation="MDFRKFAYNNIVRNFRAYLAYFLSSVFSIMIFFVFAVSMFHPII
                     TKSGMQSGSTAFMALMTSELIIFGFSLLFILYSLGNFLKYRLKDFGVLMIIGMSNRQL
                     KKLILIENLIIGFLAVMLGILLGLSISKLFLLYLSKLFYMNLTEFYFPVKAMLLTIVS
                     FMILFLITGPMSLKLLSKKSILELLVGTKKPKKEIKSSKLFGIIGVICLILGYAMILF
                     GNKLKINGGMYTTALLITLGIFLFFSQFTILILKYLKNKEKFYKNKVNMLLISNLIYK
                     LKDNTRLLFLITILLSATLVAFTTTSTLVSSQGEASKNNFPMVYSYFSEHNNEKEYEE
                     LQQIREAIKGYDYKELSFPVLKYNREVLLSVKNYNKLSKELGLDKISSKLEKYEGIII
                     PSSNSQEHINSLKQLKNYSIKNLNIEVKKSKNKIIFPTGLFSKVVVISDDLYNEVKGE
                     FSKINFHGFDYKNWQSSAKITENLKEKHFNLDREYNRSYFLTLPDMYLVELQQSKILQ
                     FMGVFIGVILFIAVFSFLYFRLYTDEIEDNVKYKKLSKIGLSFKNMNKIVSIEIGTLF
                     FIPYFIAIINSIISLLFLNQVLNNSFKLENLGILLLISSIYSLYFYLLKKNYTRKVWF
                     FD"
     gene            14035..15426
                     /locus_tag="KRO40_001957"
     CDS             14035..15426
                     /locus_tag="KRO40_001957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2092777.1"
                     /translation="MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNI
                     PGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTISIKLGQGKVEEARKLIGNAMTL
                     SVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
                     ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYIS
                     GKSNLRFSKSNLKLDKKLIKAVFAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGA
                     MATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLGSLVVATIILCMGMV
                     VVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAML
                     LSLLRQVILLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEK
                     LNENERLNEITTE"
     gene            15533..16573
                     /locus_tag="KRO40_001958"
     CDS             15533..16573
                     /locus_tag="KRO40_001958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH2092778.1"
                     /translation="MEFTKKSKLKNMYVNMNVARMLSKINEYKGRQLLYKKQPKEILE
                     NLEKKSLVDCSESTYIGNQRDSSNFNLEKLISNEVTPRSREELSIVEYRDVVKTINSA
                     YESIPISSQTILELHGYLYKFSSTRGGSYKSDNDFIEHNLKPSEFISTDSSVNKVEKA
                     VEEICEAYNTLIEEDEIDILILISAFVLDFILIHPFKEGNIKMARVLILLLLNKNGYE
                     VGRYISLGKIFDDSSYEYYSNLNYLKASIGSEKADMNAWIEYFLETILTAYEKLDDSL
                     NISDKKRQTKTSRIEKIINSTLGYFTKEDIRDLCPDIPEPTINRVFNNLRKQDKIEVV
                     ARGRSAKWKKKY"
     gene            17062..17715
                     /locus_tag="KRO40_001959"
     CDS             17062..17715
                     /locus_tag="KRO40_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBH2092779.1"
                     /translation="MKKKLLYINVNSKPEDLSSSKTVARKFINKFMEKNKDFEVEEID
                     LYKEHIPRLEYQYFEKRNSIVSEENAKNLDDKDRKELTKIRNLCDQFVNASVYVIAAP
                     MWSLSFPAPLKEYIDCIIQDGKTISFEGNDKPQGILNDIDRSMVYIQSSGGHIPWVLK
                     PVMNKGLNYVESIMKFIGIKKFDELLVDGTGTSEEERQAAIEKASEKIDGIIDGMKF"
     gene            17791..18000
                     /locus_tag="KRO40_001960"
     CDS             17791..18000
                     /locus_tag="KRO40_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092780.1"
                     /translation="MREEKSNEKYDCYWCNQENNFCVEIKDNIVMIDDGTGTLKQAVF
                     IGYKQIQINLNCSHCQNLNRIKLNL"
     gene            complement(18140..18706)
                     /locus_tag="KRO40_001961"
     CDS             complement(18140..18706)
                     /locus_tag="KRO40_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HBH2092781.1"
                     /translation="MMNNELNTIILETLNNADITSNDIPSIDLYMDQIISLIDNKLSA
                     NKRFESDKILTKTMINNYSKEGLIKPVKGKKYTKEQILQMIIIYSMKNTLTIQEIKRI
                     LHGVYEKDNFSEKDLVSCYEKFMLIKENQRKNIPDFIESNFENISINPENKDDLLIAL
                     LSLTSMADQLKNISEKLVDRYFPDITKK"
     gene            18867..19520
                     /locus_tag="KRO40_001962"
     CDS             18867..19520
                     /locus_tag="KRO40_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HBH2092782.1"
                     /translation="MYQFFLKGRDPISSLTHFIGACLSLLATIILVFQSVTLQETSLL
                     MIVSVSVFGLSLIALYSASSYYHFLKGTPEQELFFRKVDHAMIYVLIAGSYTPICLNF
                     MEKKEGIIFVTAIWIVAFIGIIIKIFWMDAPRWLSTSIYLLMGWAIVFDINAFNSIPK
                     DCLRLLIMEGVSYSIGAIIYIIKKPNISPEFGFHEIFHIFIMIGSLFHFLAVLLYVL"
     gene            complement(19678..19854)
                     /locus_tag="KRO40_001963"
     CDS             complement(19678..19854)
                     /locus_tag="KRO40_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092783.1"
                     /translation="MYKYDDYVNLTNDLDLPVEIRNKCVRIVSVSENLEDIIIVHKFK
                     LYVVNEKYIKGIME"
     gene            20382..21326
                     /locus_tag="KRO40_001964"
     CDS             20382..21326
                     /locus_tag="KRO40_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase regulatory
                     subunit"
                     /protein_id="HBH2092784.1"
                     /translation="MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYD
                     EFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKSLVPRWEDGLKLKLFYNSSIYKN
                     KNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
                     ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKREVKELLSNILSLQGNLYNVIEKS
                     NKFYCNNKMKQALEELKQVNNLIEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSY
                     KEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK"
     gene            21348..21974
                     /locus_tag="KRO40_001965"
     CDS             21348..21974
                     /locus_tag="KRO40_001965"
                     /EC_number="2.4.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase"
                     /protein_id="HBH2092785.1"
                     /translation="MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEEN
                     KIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENETDVYEIYDLGFGKCKFAVAGLKG
                     DSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
                     GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN"
     gene            22008..23057
                     /gene="hisC"
                     /locus_tag="KRO40_001966"
     CDS             22008..23057
                     /gene="hisC"
                     /locus_tag="KRO40_001966"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBH2092786.1"
                     /translation="MREKESIRELKGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDS
                     DIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVGNGSSEIIDLIIHTFVDKDEVIL
                     SFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
                     TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGI
                     RTGYMLSNSSLINSVEKVRPPYNLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYK
                     EMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKLENYYRVTIGDKEEN
                     SMFVGAIRDILKKEK"
     gene            23060..23638
                     /gene="hisB"
                     /locus_tag="KRO40_001967"
     CDS             23060..23638
                     /gene="hisB"
                     /locus_tag="KRO40_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazoleglycerol-phosphate dehydratase HisB"
                     /protein_id="HBH2092787.1"
                     /translation="MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMS
                     FHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKNALGDKKGIRRYSNIYIPMDESL
                     SMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
                     HKIESIFKAFARALKEGSEIVSNEIASSKGVL"
     gene            23640..24245
                     /gene="hisH"
                     /locus_tag="KRO40_001968"
     CDS             23640..24245
                     /gene="hisH"
                     /locus_tag="KRO40_001968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="HBH2092788.1"
                     /translation="MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILP
                     GVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICLGMQLLYEKSYEYGEYEGLGLIK
                     GSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
                     EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK"
     gene            24242..24964
                     /gene="hisA"
                     /locus_tag="KRO40_001969"
     CDS             24242..24964
                     /gene="hisA"
                     /locus_tag="KRO40_001969"
                     /EC_number="5.3.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase"
                     /protein_id="HBH2092789.1"
                     /translation="MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGA
                     EYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVIL
                     GSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
                     QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAII
                     GKALYDKKIDFKEAQQLCLLGE"
     gene            24946..25704
                     /gene="hisF"
                     /locus_tag="KRO40_001970"
     CDS             24946..25704
                     /gene="hisF"
                     /locus_tag="KRO40_001970"
                     /EC_number="4.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000880088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="HBH2092790.1"
                     /translation="MLTRRIIPCLDVRNGRVVKGKKFKDIVDVDSPEVLGKFYSDCGA
                     DELVFYDITASNEERKTSLEFVTKVAENINIPFCVGGGVNKLEDFTDILRKGADKVSI
                     NSSAVKNPELIREASLKFGAQCVVLSIDAKKNEEGSWSVYVKGGREKTNLDAIEWAVK
                     GVELGAGEIVVNSMDEDGMKNGYDIELLSKITSLVNVPVIASGGAGKKEDFYEAVNKS
                     NVDGILAASVFHFGEIKINDLKKYLKDMGVEVRL"
     gene            25732..26400
                     /locus_tag="KRO40_001971"
     CDS             25732..26400
                     /locus_tag="KRO40_001971"
                     /EC_number="3.5.4.19"
                     /EC_number="3.6.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphoribosyl-AMP
                     cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE"
                     /protein_id="HBH2092791.1"
                     /translation="MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLA
                     YMNKDAIKKTLKDKVACYFSRSRQELWVKGETSGNTQKVVKMSYDCDVDTILLFVEQT
                     GVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
                     GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELL
                     KRRK"
BASE COUNT        10491 a         2589 c         4565 g         8850 t
ORIGIN      
        1 aatataatta atacttacga aaatgtaacc ttaaattaat ataattaaat gtttaaaagc
       61 cattttaata tatataatat atttgtgaga attgataaat aactaattgt gatgaaaggt
      121 gattattaac tatggaagaa atattatctg ttgaaaatat aaaaaaggag tatggaagaa
      181 aaggttcaaa acatgaagct ctaagaggaa taactttcaa ggtttataaa ggagaatttg
      241 ttggtattat ggggtcttcc ggtgctggta aatcaacact tttaaatatt atttctacaa
      301 tagatttacc ttcatcagga gatatttata taaatggaaa gaatactatt aaaatgaagc
      361 aaaatgaatt ggcagatttt agacgtgata atctaggctt tgtatttcaa gattctaatc
      421 ttttggatac acttacaata aaagaaaata taatgttgcc tctttcttta aaaaatgaaa
      481 gagtatcagt aatagaaaat agaataaaag agatttcaaa agaattaaat atagaatcta
      541 tattagataa ataccctggc gaagtttctg gtggacaaaa gcaaagagga gctgtatgta
      601 gagctatagc aacaaaacca tcattagtac ttgcagatga gcctacagga gcattagatt
      661 ctaaatctgc tagggatttg ttgaattgtc tattaaaatt aaacaaagac agcaataaaa
      721 caatattgat ggtaactcat gatgctataa gtgcgagttt ttgcaataga atactcttta
      781 taaaggatgg aataatattc acagaaattg taaagggaga aagtaacaga gagttctata
      841 ataaaatagt aaatacagtt tccttaattg gaggagttaa taaaaatgac tttatttaga
      901 attgcaatgc aaaatgtaaa gaatagtttt tttaattatt taatgtactt tatttcaatt
      961 gtatttagtg tatttgtatt ttttagtttt aaatctatag agtataatga agcgttgagt
     1021 tcacttggag agaaaaccag gatgagtatt aatacaagtt caattgtaat agtggtattt
     1081 gtatttttat ttatatatta ttcaaactca ttttttttca atagacgtag gcgagaagta
     1141 ggaacttata gtttacttgg aatgaggaaa aatcagatag gaaaaatatt tttatatgaa
     1201 acttttttga tgggtatagt tgcaatacta ataggtatat ttttaggact gttattttca
     1261 aagcttatga ctatgatgct tgtaaaatta atgaatgaaa tgatagtagt aaatatgaac
     1321 ttaagtataa aggccttagt tcagacatta gctgtatttt taataatatt tatagttatt
     1381 ggaataagaa atactatagt tatcagaaat aagagaatta tagagttatt taataaatat
     1441 ccagaaaagt ataagtttaa aaaatttata aagttaaaat gtgtacttgg tgttttatta
     1501 atagctattt cttatttaat gtcaattagt tattttattg ctgaaaatat tatgctttca
     1561 gtttttatat tagttacaat aatacctgga acttttttat ttttttcatc aactatgtat
     1621 atgattattg atgctgttaa gaagagaaaa agtttttatt ataagggaca gaatttaatt
     1681 gcattttctg aacttggatt taaattaaag agcaatagta gtgtattggc tgtaatagca
     1741 atattaatag ctacaagtgt aactatgcta gggtttacca tatcacttta ttacgatata
     1801 gataggaaca taagtgaaaa ttataaatac agttatacca taaatttagg aaattcttat
     1861 gtaaataacg aaattgacaa attattatat aaatataaaa aagataataa gataatcttt
     1921 gataaaacaa tagaacttat agacaaagat ataaatattg aaatgtatta taaaaatgga
     1981 aatagttata tagaagatag aacgtctgta gatattatta gagaaagtga ttttaaaaaa
     2041 ttaagacaat atcagaataa caattatgaa gaattaactt caaaggaatc tgtgtactat
     2101 gtttctgatt catacaaaaa aatatttttt aaagactttg agattgaaaa aataaacttg
     2161 catattaaag atgcaaatga gtatgatata aatctgttta aagtacaaaa aagcatcttg
     2221 gagccagaaa taaattcaca agctacgttt gatttaattg tagtaaaaga tgacgtattt
     2281 aatcagttaa aattacatgg aaattctaga ttaataagat taattgatat aaaaaatgaa
     2341 aaaaaagaac tggatttgac tttaaaatta aaaaatatag taagtgaaaa tatgaaattt
     2401 acttatcctt ttaattttac atcaagtatt gaaagttata ataacttgat aaaattaagt
     2461 ggtctaatgc tgtttatagg catatttttg tctgtagtat ttcttttatg tacaggtagt
     2521 ataatcttat ttaaacaatt atcaaatata tatgatgata aggaaagata tattatgtta
     2581 ataaaacttg gagcaaataa taaagatatt gagaaaataa tatcaaaaca gttaaaagtt
     2641 atatttttaa tgccattagt tgtaggtaca gttcataatt tatttgctat gtctatagca
     2701 caaaagttta taccaaggtc attacttgta ccaattatca taactctagt catttatttt
     2761 ataggatatt ttatatatta ttttttaact ttaaaatatg ctctaaacat gataaaagaa
     2821 taaattattt ttaagttaaa agaattagat atatgttttg aataaaataa cttatttaag
     2881 tgcagataga aaatactaga attgagttta agatatttat ttaaaaataa aattaaagtt
     2941 aggaaaaagt ctatatttta tatcattttg tatcagttac attacttgat gttatataat
     3001 aaatctaagc agaatatcaa ataaaaaatg acgaggagct gaaatttatg aagtttaatg
     3061 cctaccaaca taaatactca tcaataagaa atgtcgtgta tgctaaaaat ggagcagttg
     3121 caacatcaac accattagca tctcaagctg gacttgaaat actaaaaaag ggtggaaatg
     3181 ctgttgatgc agcagttgca acagccgcca cattagcagt agtagaacct acaagcaatg
     3241 ggattggagg agatgcatat gcccttgttt ggatagagga agaaaaacga ttgtatggtt
     3301 taaattctag tggctttgct ccagaaaata tggaattaaa aaattataat aatatgaaag
     3361 aaatgccaaa atatgggttt ggagcagtaa ctgtacctgg aataccagca gcttggtcag
     3421 aattaaataa aaaatatggt aaacttagct taatggaatg cttatctcca gcgataaact
     3481 atgcaagaga gggatacgta gtatctccta atgtagctaa ggtatggaaa aaatcatatg
     3541 aactctatga aaaagaactt attggagaag agttcaaacc atggtttgat acattttcta
     3601 aagatggtaa agccccagag gctggagata tatttatatg tgaagaacag gcaagtacat
     3661 tagaagagat agcaaatact caggctgaaa gcttttatag aggaagactt gctgataaaa
     3721 tagatgaata ttctaaaaaa tttaatgggg ctataagaaa gagtgactta gagtgttttt
     3781 atccaacatg ggtagaacct ataagtacag aatataaggg atataaaata tttgaaatcc
     3841 caccaaatgg tcatggaata acagttttaa tggcacttaa catattaaaa gaattggaat
     3901 tagaaggaaa tatagaaaat gtagaagaca tacataaaat tatagagagt ttaaaattag
     3961 cttttgcaga ttctaaaaca tatgtaactg atatagagca tatgaaggta aagattcagg
     4021 aattactaag ccaagagtat gccaaaaaaa gaagtttatt aattgacaat aaagaggctt
     4081 tgtatccaac tgcaggagag ccatattgtg gtggtacagt atacctttgt actgcagata
     4141 aggatggaaa tatggtttca tatatacaga gcaattacat aaattttggt tcaggaattg
     4201 tgataccaag aactgggatt gctttacata gtagaggaaa taattttaat ttagacccta
     4261 aacaccacaa tgtagtaaaa ccatttaaaa aaccttatca tactataata cctggatttt
     4321 taggtaaaga agataaagca ataggtccat ttggtgtaat gggagctttt atgcaaccac
     4381 aaggacatat tcaggtgtta acaaatatga ttgattttgg attaaatcca caagaggcgc
     4441 tagatgctcc aagatggcag tggataaaag gaaaagaaat agaagttgaa ccagagatgc
     4501 caaagcatat aatagattca ttaattgaaa agggtcatga aataaaagta attcatgata
     4561 ctgtcgacat gggacgaggt caaataatat ttaaaacaga acaggaaagt tatatttgtg
     4621 ggacggaatc aagatgtgat ggtcatattg cagtttatta atattatcaa ctaaaatata
     4681 tataataaat ttaaagagta tatgaaataa taagtaaagg cgaaagtcta caatgactga
     4741 cgcctttaca aaatttaagc tatcatatgc tgattttata tagattatga gccttattct
     4801 tgaccagttt tgatttcatt gtcatcataa ctaatccagt cgctaaagct accaatataa
     4861 atcttgtgag gtatatccag ttctctaaga gcaagactgt taacacaagc agatatccct
     4921 gaaccacaag ataaaattac ttcatcataa ttatttaaat ctttaaagaa tttttttaaa
     4981 aattctatat ctttaagtga gccattttca aagtcacttt ttattaaatc cttacaaaaa
     5041 taattttttg cacttggtat atgaccagct tttgagtaag caggttcaac taaaccctgg
     5101 tatctctcat tagcacgaca atctattatt acagtatctt ttttgtataa tttagactta
     5161 acatattcca ttggaacaac taaatcattg tttatatttg gtctaatttc cttacctgta
     5221 caacttggta tattcacttt ctcttctaat tctccacctt cctttacgaa agatgttatt
     5281 cccccatcta gtacatagac atttttaagc cccaaatgtt ttaattggaa aaataatctg
     5341 caagctccat ttaaatctcc atcatcataa gttacaatcg tagtgtcgtt atcaacaccc
     5401 attttttcta atttttcttt tagtattaaa gggtcttgta aaggattttt accaccatgt
     5461 tcttttgtag gagatgataa atccttgtct atatctaaga taaaactgcc tttgatgtgt
     5521 ccttttttat aagaatcaat accataagtt ctattgataa gatcaaatct acaatctatt
     5581 acaactagat tatcattttt ttctagtttt gatataagtt cttttgctga aataatgttt
     5641 ttcaaagaat gtacctcctg tgtttatatt atctttattt taatttatat taattattaa
     5701 ctttataaac taatattatt ataatttatt acataagtaa ataaatcttt agaaattgta
     5761 aaaattttat ataaaaattc aaataattaa tgaatattga aaattttaga tatataataa
     5821 aataagagta tattttatac aatatgaaag ctggtattgc aatagattaa agccttatac
     5881 acgtttagtt tttaaagaaa ttagtgttat tatgaaaacc taagttaatt tattaaataa
     5941 ataattgaat aaaaaaattt tattatgtat ttataaaatt tttgttacaa atttggcata
     6001 atatagtata ctttaagtgt gtattaggtt aaatctataa caaattagac gtatgatata
     6061 gacttagtgt ttattggcat ttacaagaaa tttgttaata tcaactattt gtagtttggg
     6121 cagttataat tattataggg gggatgtcca atacaaaaca atcaaccaag aactaatatt
     6181 atattataaa gagttatagt tttgtgtgtt tatgttttta attaaattta aagtgggaaa
     6241 aatatatttg ttagaatgga gaatagcgag atgagtaata aaatagttag taagagacaa
     6301 ttaacagata gtatttattt aatggaaata gaggcaccta gagttgcaaa atcttctcaa
     6361 ccaggtcaat ttataataat taaaaatgat gaaaaaggag agaggattcc tcttacaata
     6421 gctgactatg atagagaaaa aggaacagta actattgtat tccaaacagt tggtgcttca
     6481 actaaaaagt tagcaatgtt tgaagaaaac gattttgtaa tggattttgt agggccatta
     6541 ggacaagcaa gtgaatttat acatgaagat atagaagaat taagaaataa aaagatatta
     6601 tttgtagctg gtggagttgg ttctgctcca gtttatccac aagttaaatg gtttaaagag
     6661 catggattag atgtagatgt aataattggt gcaagaacta aagaattaat tatattagaa
     6721 gatgatatga aaaaagtagc taaaaatgta tatgtatcaa cagatgatgg tacatatgga
     6781 tttaatggaa gagttacaga cctattaaaa gatttagttg ataatcaagg taaaaaatac
     6841 gaccaagcaa tagtaattgg accaatgata atgatgaaat ttatgtgcca attaactaaa
     6901 gaactaaata tacctactat agtaagttta aatacaataa tgatagatgg aacaggtatg
     6961 tgtggtggtt gtagagttag tgttggaaat gaaactaagt ttgcatgtgt agatggtcct
     7021 gaatttgatg gtcatttagt tgattttgat caagcaatga gaagacagtc tatgtacaag
     7081 actcaagagg gaagagctat gctaaaactt gaagaaggcg atagtcatca tcatagtaat
     7141 tgtggatgtg gaggtaacaa ataatggatg ctaaaaaagt aaaagtacca gttagagaac
     7201 aagaacctgc agtgagagca acaaattttg atgaggtatg cttagggtat aataaagaag
     7261 aagctatggc agaagctaat agatgtttag cttgtaaaaa accaaaatgt gtgggtggat
     7321 gtccagtagg aatcgacata ccagggttta taacaaaaat taaagaagat gatatagaag
     7381 gtgctgctaa agtaatagct aagagcagtt cattaccagc tgtttgtggt agagtatgcc
     7441 cacaagaaag tcaatgtgaa ggtgtatgta tacttggaat aaaatcagat gctgtatcaa
     7501 taggtaaatt ggaaagattt gtagcagatt ggtcaaaaga aaatgacata aatttatctg
     7561 atacagagcc taagaaaaat caaaaagtag cagtaatagg aagtggtcca gcaggtctag
     7621 cttgtgctgg tgatttagct aaaaaaggct atgatgtaac aatctttgaa gcaatgcatg
     7681 agccaggtgg agttttaact tacggaatac ctgagtttag acttccaaaa caagctgttg
     7741 ttcaacctga aatagacaat ataagaaaat taggtgtaaa aatagaaact aatgtaattg
     7801 ttggtaaaac aattacagta gatgaactta tagaagatga aggatttgaa gctatattca
     7861 taggttcagg agctggtctt ccaatgttta tgaatatacc aggggaaaat gcaaatggag
     7921 tattttctgc aaatgagttt ttaactagag taaacttaat gaaggcttat agagatgatt
     7981 atgatacacc tattagttct ggtaaaaaag ttgctgtagt aggtggtgga aatgttgcta
     8041 tggacgctgc tagaactgca ttaagattag gttcagaatc atatatagtt tatagaagaa
     8101 gtgaaaaaga gcttccagca agagctgaag aagttcatca tgcaaaagaa gaaggcatta
     8161 tatttaatac attaacaaat cctaaggaaa ttttagtaga tgaaaatgga tatgttaaag
     8221 gtatggtttg tataagaatg gaattaggag agccagatga ttctggaaga agaagaccta
     8281 tagaaataga aggttctgaa tttgtacttg atgtagacac agttataatg tcacttggaa
     8341 caagcccaaa tccactaata tcttctacaa caaagagtct tgatataaat aagaagagat
     8401 gcttaataac agatgaaaat ggtcagactt ctaaagaggg tgtatttgca ggtggagatg
     8461 ctgttactgg agcagcaacg gtaatatctg caatgggtgc tggtaaaaca gcagcagcat
     8521 caatagatga atatttaaaa gcaaaagtta atgcttaatt tgtaaattaa agagagggtg
     8581 tctcaaaatg aactttttag ttcatgagac actctttttg tacaaaatca aatatgtttt
     8641 aatcatttca acaatgaaaa tttcattcct gtagaaagtc taacttttag gtcttagtac
     8701 aatctctatt ttgatgtagc cactttttta gatggtttaa taatttatca gttattattg
     8761 taatatttga tactaagtaa cataactttg tctaactatg ataaaatagt tatacaataa
     8821 aggtcttgta aggagtgaat aatgtgtggc taataaaatc agatttgtca aatctaacat
     8881 taaataatag aaaaataaat tgtgtaatta atggtatttt aatatgaaaa aaagagaaaa
     8941 agtatttgat gggctagttt ttaagcatat attaatctta ttaatactat tagttttgat
     9001 tgatttaaca agtaccatca tatatgcaag taactctatg gaaattactt ctagaaatat
     9061 gattgaggca tcaaaaagag aacttgaaaa ctatttagaa gtaaacatat ctttattaaa
     9121 agctcttagt caagatgata gattttctaa tggtgaaaca tcactaattg aaaagggaaa
     9181 attattaagt ccatatcaaa aggaatataa tctttttatg attggtataa cagatacaaa
     9241 aggaaatgct tcaagtacat atagggaaaa tgttaactca ataaaagata agcctagttt
     9301 tgagaaagca attaaaacaa agcaagtagt agtttcagat attgaagtca gtaatgtaac
     9361 aggtgacaaa gtatttatca tatatgtacc aattgtaaaa aataatgaga tgattgggac
     9421 catttttgct tctttttatt ttcaagatgt aaataattta ataagtagaa gcaattttga
     9481 tgattctatt aaatttctaa tgatagataa agattatact attatttctc atccaaacaa
     9541 aaaatatgta aatgataaaa gtaagatgct tgatttagaa gggaatatta taggaaccac
     9601 taaaagtgaa atcttaaaaa atataaataa aaaatgtcaa ggtgattttt tatcttggga
     9661 taattggaga ttatataatg taaaatatac gaacataaag tggactaatt ggactttagt
     9721 atcaaaatgt aatatattta agaactttaa aaatctaata gttaatttta tgataaagtt
     9781 gtatttttat atagtaatat ttatgatatt gtggaaatta agtaatgcta aattaataga
     9841 acaacttaaa aaattggctt attatgattc tttaagtgga ataaaaaata aagaaaagtt
     9901 tagaaaagat tctatgtata ttttaaagaa ttattatcaa gataattttt acttagtaca
     9961 attggatgtc aataaattta aatatataaa tgagatgttt ggatatgctg aagggaataa
    10021 gatattaatt catatatcac aggttttaaa taataataca aataaatatg aaatttgtgc
    10081 taggatggat aatgaccatt ttatattgtt gattgcttgt aacactgaag atgaactttt
    10141 aaatagatta tctaaaataa ataaagaaat ttgtaactta aatactacta actcatctaa
    10201 gtataaaatt gttatgtcaa gtggaatata taagattact aaaaaggatg atattaaaaa
    10261 gattgacttg ttaattgata gagcaaatat tgcagcaaaa agtaaaaagg aaaaatatga
    10321 acattcatat tcatttttta atgaagatac aagaaatcga ttgtacaagg aaaaacgatt
    10381 ggaagataat atgaataaag ctttagaaaa aggtgaattt atagtatatt atcaacctaa
    10441 gtatagttta gatgatgtaa atgaaattga aggagcagaa gccttgataa gatggaatag
    10501 tccagaattt gggtttattt cacctataga ttttgtacct ttatttgaaa agaatggttt
    10561 tattgtaaat attgatatgt tcgtgtttga agaagtatgc aaaacattaa acaagtggat
    10621 aaataaaggg tatactcctg taccaatctc tgtaaatatg tctagagttc atttatatag
    10681 ggataatttt atagaaaata taactgattt gataagtaaa tacaatatat ctcctgagtt
    10741 tattgagctt gaactaacag aaagtgttgt gtttgataat ttaaatatat tgattgatat
    10801 aatgaaaaag attaaagaga taggattcct tatatcaatg gatgattttg gttcgggata
    10861 ttcatcttta aatctgttaa aagacctttc ttttgatatt ttaaaattag atagaggatt
    10921 tttaatcgaa acaacagata caaaacgtgg aaaaattatt atttctaaga ttgtggaaat
    10981 ggcaaaagcg attgatatta aagtaatctg tgagggcgta gaaacttatg aacaagtaga
    11041 gttcttgaaa gagataggtt gtgataaggt tcaaggatac ttatttgcta aacctatggt
    11101 attagatgaa tttgaaaaac acttaaactt taaatttgat taatcattaa taattattag
    11161 actataagat accctaacaa cttacttaca aatatgtaag ttaattgtta gggtattttt
    11221 atggttaaag tagtatattc acgatattat ggtattgtag taaaaataaa aaattatgga
    11281 gaatataaaa tgaacatatt gagtattaga aatatatcaa aaacatattg tggaaatatt
    11341 ccatttaaag cattagataa ggttagtcta aatatagaaa agggagaatt tgtgtctgtt
    11401 atgggaccat ctggaagtgg taaatctact cttttaaata taatatctac agttgataga
    11461 cagagtgaag gtgaggttgt attagatgga tatgatgtaa gtaaattgaa aggagaaaaa
    11521 cttgctgaat ttagaaggaa acaacttggt tttgtatttc aggattttaa tttgattgac
    11581 actttaactg ttggcgaaaa tattatgttg ccacttacac tagagggggc aagtatcaaa
    11641 gatatgaata tacaaactaa aagtatatct aaatttttag gaatagataa aattttagat
    11701 agaaaaacct atgaaatttc aggaggtcaa gctcaaaggt gtgctattgc tagagctatt
    11761 ataaataaac ctgccatact tcttgcagat gagccaactg gaaatcttga ttcaaaatct
    11821 actgatgatg ttttgaaatt atttactagg ataaacaaag aacaaaaggt aacaacactt
    11881 atggtaactc atgaagcata tagtgcaagt tattcagata gagtaatttt tataaaagat
    11941 ggttgtatat atacagaaat aaaaaaatct gaaagcagta attctttcta ttctgatata
    12001 ctagctgttt tgtctcaaat aggaggtgta agatagtgga ttttagaaag tttgcttata
    12061 ataatatagt tagaaatttc agggcatatt tagcatattt tttaagttct gttttttcta
    12121 taatgatatt ttttgttttt gcagtgtcta tgttccatcc aattataaca aaatctggaa
    12181 tgcagagtgg ttctactgca tttatggctc ttatgacttc agaattaata atattcggtt
    12241 ttagtctact ttttatattg tactctttag gaaatttctt aaaatataga ttgaaagatt
    12301 ttggagtatt gatgataatt ggaatgagta acagacaact gaaaaaattg atattaattg
    12361 aaaatttgat aataggattt ttagcagtga tgttaggaat attacttggt ttatcaattt
    12421 caaaattgtt tttattgtat ttaagcaaac tgttttatat gaatttaact gaattttatt
    12481 ttccagtaaa agcaatgcta ttgactattg tatcatttat gattttattt ttgataacag
    12541 gaccaatgag cttaaaatta ttgagtaaaa agagcatttt agagctttta gtaggtacaa
    12601 aaaagcctaa aaaagagata aaatcttcaa agctatttgg aataattggt gtaatatgtc
    12661 ttatattagg atatgctatg atactatttg gcaataagtt aaaaataaat ggaggtatgt
    12721 atacaacagc actattaatt actttgggga tatttttatt tttttctcaa tttactattt
    12781 tgatattaaa gtatttaaaa aataaagaaa aattttataa gaacaaagta aatatgttac
    12841 ttataagtaa tttgatatat aaattaaagg ataatacacg attgttattt ttaataacaa
    12901 tacttttatc ggctacttta gtagcattta caacaacttc aacacttgta agttctcaag
    12961 gagaagcttc taaaaataat ttcccaatgg tttactcata tttttcagag cataataatg
    13021 aaaaagaata tgaagaacta caacaaatta gagaagcaat caaaggatat gattataagg
    13081 agttaagttt tcctgtactt aaatataata gggaagtctt actaagtgta aagaattata
    13141 acaaattatc aaaggaattg ggattagata aaattagttc aaagttagaa aaatatgaag
    13201 ggattataat tcctagtagc aattcgcaag aacatataaa ttctttaaaa caattaaaaa
    13261 attatagtat aaaaaattta aatatagaag taaaaaaatc aaaaaataaa ataatttttc
    13321 ctacaggact gtttagtaaa gttgtggtta taagtgatga cttatacaat gaagtaaaag
    13381 gtgaattttc aaaaattaat tttcatggat ttgattataa aaactggcaa agcagtgcaa
    13441 agataactga aaatttaaaa gaaaaacatt ttaatttgga tagagaatat aacaggtcat
    13501 attttttaac attaccagat atgtatttag tagagttaca acaaagtaaa attcttcaat
    13561 ttatgggtgt ttttatagga gtgatattat ttatagcagt ttttagtttt ttatacttca
    13621 gattatatac agacgagata gaagataatg taaagtacaa aaaactatca aaaataggtc
    13681 tatcttttaa aaatatgaat aagattgtta gtatagagat aggtacattg ttttttatac
    13741 cgtattttat agcaattata aatagcataa tttctttact gtttttaaat caagtattaa
    13801 ataatagttt taagttagaa aatttgggta tattactact gatatcatct atatattcac
    13861 tttattttta cttattaaaa aaaaattata ctagaaaagt ttggtttttt gattaaagtg
    13921 gtatataata gatatataaa ttaatattta aaaagtagtt aatattaggg gagggcattt
    13981 gcacctccct tgtaatatgt ggaaaattga atattagaag aaggaggaga cttgatggaa
    14041 aatcaacaat tattaggaac agaacgaatt agtaaattac tactaaaata ttctatacca
    14101 gctataatag gtatgttggt aaatagttta tataatgtag tagatagaat ttttattgga
    14161 aatataccag gggttggacc acttgcaata acaggtcttg gtgtaacaat gccaataatg
    14221 acaataatac ttgcatttgg gatgttgata ggtataggaa ctactactac catatcaata
    14281 aaacttgggc aaggtaaagt agaagaggca agaaaactta taggaaatgc aatgacgtta
    14341 tctgtaataa caggaattat cataatgata cttggaatat tatttgcaaa taaaatactt
    14401 acattgtttg gagcaagtga aaatacttta atatatgcaa aatcatatat caatattata
    14461 ttattaggta cagtagtaaa tcttctttcc ttttctttaa accactcaat aagagctgat
    14521 ggtagtccta aaatttcagc aggaataatg atagtaggat gtttaactaa tatagtttta
    14581 gactggatat taatatttgg attcaatttg ggaatacaag gagctgcaat tgctacagta
    14641 acttctcagg ctcttacagc tattttaact atagggtatt atataagtgg aaaatcaaac
    14701 ttacgattca gtaaatctaa tctaaaatta gataaaaagc taataaaagc agtgtttgca
    14761 ataggtatgt cgccatttgc tatgcaactt gcagcaagtt tagttcaagt aatatcaaat
    14821 attgcactta aaactcatgg tggagattta gctatagggg ctatggctac tatttcttct
    14881 attgcaatgg tatttttgat gcctatcttt ggaataaatc aaggagcgca acctattata
    14941 ggtttcaatt atggagctga aaaatatgat agggttaaaa aagcatattt aggttcatta
    15001 gtagtagcta ctataatttt atgtatgggt atggtagtag ttatgctttt cccagaagct
    15061 attataggta tatttaataa agaccctgaa cttatgaata tatctgttaa tggattaaga
    15121 atatacttac ttatgttgcc aattgtaggc ttatcagtta caggaacaaa ctttatacaa
    15181 tctataggaa aagcaaaaat ggctatgtta ttgagccttt taagacaagt aattttattg
    15241 ataccagcag tattaattct tcctacattc ttaggtttac agggtgtatg gacagctcaa
    15301 ccagtgtctg attttatagc tacagtaatt acaggtatag ttgtatttag agaattaaaa
    15361 agatatactc ctaaaactga aaaattaaat gaaaatgaaa gactaaacga gataactact
    15421 gagtaaaaat ataaattcag ataattgagc aagaaattgc aaaaaatacg attatatgat
    15481 aaaataaaac cgctgtcaag gataagagaa attctaatta tggagtgatt ttatggaatt
    15541 tacaaagaaa agcaaattaa aaaatatgta tgtaaacatg aatgtagcta gaatgttgtc
    15601 taagataaat gagtataagg gtagacaact gctttacaaa aaacaaccaa aagaaatttt
    15661 agaaaactta gaaaaaaaat ctttagtaga ttgttctgaa tctacataca ttggaaatca
    15721 aagagatagt agtaatttta atctagaaaa gttgataagt aatgaagtta cacctagaag
    15781 tagagaggaa ttgagtattg ttgaatacag agatgtggta aaaactatta acagtgctta
    15841 tgagagtatt cccatcagtt cacaaacaat tcttgagctt catggatact tatataaatt
    15901 ttcatctact agaggaggaa gttataagtc agataatgat tttattgaac acaatttaaa
    15961 acctagcgaa tttataagta ctgattcaag tgtcaataaa gttgaaaaag ctgtagaaga
    16021 aatatgtgaa gcttataata cattgataga ggaagatgaa attgatatat taatattaat
    16081 ttctgcattt gtgttagatt tcatattgat acatccattc aaagaaggta atataaaaat
    16141 ggcgagagta cttatcctat tgttactaaa taaaaatggg tatgaagttg gaagatatat
    16201 aagtttagga aagatatttg atgatagttc atatgaatat tatagtaatt taaattattt
    16261 gaaagcctca ataggtagtg aaaaagcaga tatgaatgca tggattgagt attttttaga
    16321 gacgatatta actgcatatg agaagctgga tgatagttta aatatatctg ataagaaaag
    16381 acaaacaaaa actagtagaa tagagaaaat aataaattct acccttggat attttacaaa
    16441 agaagatata agagatttat gtcctgacat tccagaacct actataaata gagtttttaa
    16501 taatctaaga aaacaagata agatagaagt tgttgcaaga ggaagaagtg caaaatggaa
    16561 gaaaaaatat taaaaaatgt ttagataact aaaatggtat agtgttttac actataccat
    16621 ttttaatgtc attagcatga gcaataattt aacaacttaa gcaatatcaa ttttatttat
    16681 tgattatttt tgaactgaaa aatggcgtta tatggtatac ctcagtggta attaattttg
    16741 gatgagaaga tataatatta cagaatatat taggagtata tgtagaaaaa atataataaa
    16801 agtgtgaggc ttagtaatta acaaattatg tggcttcaca cttttttata aaataaagat
    16861 acttagcaga ataatatttt agttgatatg tttataagat ggtacttgtt tgggtaaaag
    16921 tataaatagt aaaaaagtag aagtaatgtg tataaaaaca taagttacat tctgtaataa
    16981 tagttatttt ataattcaac aaaagaatag aatgggtata tttgtgaaat aataatataa
    17041 aataatctta ggagtgagct tatgaagaaa aaattattat atataaatgt aaattcaaaa
    17101 cctgaagact tatcttcaag taaaactgta gcaagaaaat ttataaataa atttatggaa
    17161 aaaaataaag attttgaggt tgaagagata gacctttata aagaacatat accaagactt
    17221 gagtatcagt actttgaaaa aagaaatagc atagttagtg aagaaaatgc taaaaattta
    17281 gacgataagg atagaaaaga gcttacaaag attagaaatc tttgtgacca atttgtgaat
    17341 gcaagtgttt atgtaatagc agcacctatg tggagtttat cttttccagc accacttaaa
    17401 gagtatatag attgtataat tcaagatgga aaaactatat cttttgaagg caatgataaa
    17461 ccacaaggaa ttttaaatga tattgataga agtatggtat atatacaatc ttctggtgga
    17521 cacataccat gggtgttgaa gccagttatg aataaagggt taaattatgt ggaaagtatt
    17581 atgaaattta taggaattaa aaaatttgat gaattgttag tagatggaac tggaactagt
    17641 gaagaagaaa gacaagctgc aatagaaaaa gcatctgaaa aaatagatgg tataatagat
    17701 gggatgaaat tttaattata atattttatt aaaaatataa aggaaaaacc tcttttaatg
    17761 tagaaactta tattgaagga ggcgagaatc atgcgagaag aaaaaagtaa tgaaaagtat
    17821 gattgttatt ggtgtaatca agagaataat ttctgtgtag aaataaaaga taatatagtc
    17881 atgatagatg atggcactgg tacgttaaaa caagccgttt tcatagggta taaacaaatc
    17941 caaattaatt taaactgttc acattgtcaa aacttaaata gaataaaatt aaatttgtag
    18001 aattttaaaa tggaaattat tgaaggaatt aaaaatagaa agtgttaata tttagactga
    18061 aaattatatt ttatacaata aaagtttatt taaataacat tgtattttaa tatttatttt
    18121 cagtcttact ttattaaaat tattttttgg ttatgtctgg aaaatatctg tctactaatt
    18181 tttctgaaat attttttaat tggtcagcca ttgaagtcag acttaataag gctatcaata
    18241 aatcatcttt attttctgga tttatactaa tattttcaaa attagactct ataaagtccg
    18301 gtatattctt tctttgattt tcttttatta acatgaattt ttcgtaacat gaaactaaat
    18361 ctttttcact gaaattatcc ttttcataca caccatgtaa gattctttta atttcttgta
    18421 ttgtaagtgt atttttcata gaataaataa ttatcatctg taaaatttgt tctttagtat
    18481 acttttttcc cttaactggt ttgattaatc cctctttgct gtaattattt atcatggttt
    18541 tagtaagaat tttatcactt tcaaatcttt tattagcaga aagcttattg tcaattagag
    18601 aaataatttg atccatatat aagtcaatag atggaatatc gtttgaagtt atatctgcat
    18661 tatttagtgt ttctagtatt atagtattaa gttcattatt catcatatgt tacctccata
    18721 atatatataa tacactaaat tagaaagtaa aacaatatta aggcttgtaa aaaaaacata
    18781 aagtggtata attaaatata taatatagta atcaaaacta tatttatgaa tctgattttt
    18841 aaaatacata attgtaggag gacgaaatgt atcaattttt tttaaagggt agagacccaa
    18901 taagcagttt aactcatttt ataggtgctt gtttatctct tttagcaact ataattttag
    18961 tttttcaatc tgttacatta caggaaactt ctctcttgat gatagtatct gtatctgtat
    19021 ttggactttc actaattgct ttatatagtg caagttcgta ttatcatttt ttaaagggga
    19081 caccagaaca agaattgttt tttagaaaag tagaccatgc aatgatttac gtattgattg
    19141 ctggctctta tacaccaata tgtctgaatt ttatggaaaa aaaagaaggc ataatatttg
    19201 ttacagcaat atggatagtt gcatttattg gcataataat aaaaatattt tggatggatg
    19261 cacctagatg gttatctacc agtatatatt tacttatggg gtgggcaatt gtttttgata
    19321 taaatgcatt caattcaatt cctaaggatt gccttagact attaattatg gaaggtgtat
    19381 cttactctat aggtgcgatt atttatataa ttaaaaagcc taatataagt cctgagtttg
    19441 gatttcatga aatatttcat atttttatta tgataggttc tttatttcac tttttagcag
    19501 ttttattgta tgttttatag ttttaaaaga tttgattaat tgatactaaa attctacaat
    19561 gaataaaatg gaactgcctt atatagatta tatcttagac aataagacag ttccttatta
    19621 taaatattaa attctactta taataaaatt ttgataaaaa tagtccattc aaaatgccta
    19681 ttccataatt cctttaatgt acttttcatt tacgacatat agtttgaatt tatgtactat
    19741 aattatatcc tctaaattct ctgaaacact aacaattctg acacatttgt ttctaatttc
    19801 tacaggtaaa tctaaatcat ttgttaaatt cacatagtca tcatatttat acataaaatc
    19861 atccctttac attaagatat acttattata ctatatttta ataagttttt ttaaattatt
    19921 acaatttttc ccgaaatttc attttttata cataaaattt ccaaattagg taaagattaa
    19981 attttttatt gtataaacaa aagttacata taaaatattt tattcaattt tttaaataac
    20041 tattgccaat ttttgaaaaa tatattatta ttaatagtaa caaaaaactg taaatttaga
    20101 atattaataa aaattatttg ggaggaaatt atcatggtga gattaaatat agtaaaatta
    20161 aatacaaaat taaatcatca ccatcatcat agattaaagg gattgtaata tgaaattaat
    20221 tcatagacac aagccctgtt tttagtgtaa ttggtcttgt atctatgatg ggaagtaatt
    20281 ttaagagaaa attatagcca tataggtata aagcctatgt ggctttttta ttgttttaaa
    20341 tttgcaaata taagagtaaa tttaatgaag agggtgagaa tgtgaaattt ttgaggattg
    20401 aagatgaggt tatttattct aaaaaaagat ataaattaaa aagggaaata gataaacttt
    20461 ttttggatga agaatatttt caaatagaac cacaattatt tgaagaatat gatgaattta
    20521 caactataaa taataaaatt ccagaagaat ctatggtaaa ggttgtaaat ggaaaagtaa
    20581 tggtacttag agctgatata actacaagta taataaaaag ccttgtacca agatgggaag
    20641 atggtttaaa gcttaagctt ttttataatt catcaatata taaaaataaa aatacagttg
    20701 gaataaaaga gataagacaa ataggttgtg agtatctagg agaagcctct gtagaagcag
    20761 atagagaagt agtgaaatta gctcttaaga tacttgaaaa atacaataat aattttattc
    20821 tagaggttgg gagtagcaag tatattcatg gtttgttaga agaattaaat ttaaataaga
    20881 attgtgaaaa tcaaattaaa aatttactat atacgaagaa cactcatgaa ctaaaagtat
    20941 atattgaaga attaaaaatt aagcgtgaag taaaagagtt attatcaaat attttaagtt
    21001 tacaagggaa tttatataat gttattgaaa aatcaaacaa gttctattgt aataataaga
    21061 tgaagcaagc tcttgaagaa ttaaagcaag taaataattt gattgaggaa tgtaattttt
    21121 tagataaggc tagatttgat ttatcaatga ttactatgct tgactattat gaaggaatta
    21181 tgtttagagg atactaccca aactcatata aagaaattct tagtggtgga agatatgatt
    21241 ctttaactaa agagtatgga aaagaaattc cagccattgg atttacacta agtgttgatg
    21301 agttaatgaa gtatgtatat aagtaaagtt tagaaggagg gattgctttg gattatttga
    21361 ctatagcact agcaaaagga cgaattgaag gggaatcatt taaaaaattt aaaaaaatgg
    21421 gtctaggaga cagtatagac acagatacga gaaaactaat ttttaaagat gaagaaaata
    21481 aaattatata tatacatgta aagccatcag atgtagttac atatgttgaa aaaggagtcg
    21541 ctgacctcgg tatagcaggt aaagatacta ttttagagaa tgagacagat gtatatgaaa
    21601 tatatgattt aggttttgga aaatgtaaat ttgctgtagc aggattaaag ggagatagca
    21661 tatatagaga agatgaatat ttaaaagtgg caacaaagta tcccaatata gcaaaaaagt
    21721 attttaaaga gaaaggtcaa aaaattgaaa taataaaatt aaatggttct gtagaactag
    21781 ctccaatagt agggttgtca gatgtaattg tagatatagt tgagactggc aatacactta
    21841 aagcaaatgg tcttgaaata ttagaagaca tatgtaatat aagtgctaga attatatcaa
    21901 atagagctag ctatagattt aaatatgaac aaattcagaa tataattcgt ttatttgaag
    21961 aacttgataa ttaaaatata attgagcttt ataaggaggg atttaagttg agagaaaaag
    22021 aaagcataag agagttaaag ggatatgaac caaatcacgt aaactgtaaa gtaaaacttg
    22081 atgcaaatga aggaagtaag aggttgttta aataccttat taaagaaatt tcagatagtg
    22141 atatagattt aaatttatat cctgaagatt cttatagtga tttgaaagaa tctataatag
    22201 attacataaa tatttctgga gtaaataaga aaaatcttct agtaggaaac ggttcaagtg
    22261 aaataattga tttaataata catacttttg tagataaaga tgaagtaata ttgagtttct
    22321 ctccaagttt tagtatgtat tctatatata gtcagataaa tgggtctaaa tttataggtg
    22381 ttgaaagtga tgaaaattta gttataaata tagataatgt gattgaaaaa gtaaaggaga
    22441 ataatcctaa aatagtaatt gtatgtaatc ctaataatcc aactggaaca atattaaaga
    22501 gggaagagat aataaagctt ttagattcaa ctaatagtct agtggtttta gatgaagcat
    22561 atatggattt tggagaagaa agcatgttaa gtgatgtttt taagtatgat aatctaatag
    22621 ttcttagaac tttatcaaag gcatttggat tggctggaat aagaacagga tatatgttat
    22681 ctaatagtag tttaataaat tctgttgaga aagtaagacc tccatataat ttaaattcat
    22741 tatcagactt tattgctaca agagcactta gaaataaaga tgtggtaaag gcttatataa
    22801 aggaagtaaa agaggaaaga gaagttttat ataaagaaat gattggtatg ggaattaaag
    22861 catataaatc acaagcaaat tttatattat tttattctga aatcgaaaat ttatcacaaa
    22921 aacttattga tagaggtgtt ttaataagaa aatttggtgg aaagttagaa aattattaca
    22981 gagttacaat tggtgataaa gaagaaaatt ctatgtttgt tggagctata agagatattt
    23041 tgaaaaagga gaaataggta tgagaatttg gaaggtagaa agaaatactc ttgaaacaca
    23101 gattttagta gaattaaata ttgatggttc tggtaaagct gaaatagata ctggaatagg
    23161 atttttagac catatgctta ccttaatgtc atttcatggc aagttcgatt taaaagtgat
    23221 ttgtaagggt gatacatatg tagatgacca ccatagtgta gaagatatag gtatagctat
    23281 aggtgaagca tttaaaaatg ctctaggtga caaaaaagga atacgaagat attctaatat
    23341 ctatatacct atggatgaat ctctatcaat ggtagcaata gatataagca atagacctta
    23401 tcttgtattt aatgctaaat ttgataccca aatgattggt agtatgagta ctcaatgctt
    23461 taaagaattt tttagagctt ttgtaaatga atcgagagta acattacata tcaatctctt
    23521 atatggggaa aatgaccatc ataagataga aagtattttt aaagcatttg caagagcttt
    23581 aaaagagggt agtgaaatag tttctaatga gatagcatct tcaaaggggg ttttgtagaa
    23641 tgaatataat agtagactat ggtcttggaa atatagattc tgtgtctagg ggttttagaa
    23701 aagctggaat agaaactaaa atttctagtg atatagatga aataaaacag gcagattcac
    23761 ttatacttcc aggtgttgga gcttttagag attctataag tgccttagat aaactaggat
    23821 tgataccaat aataaaggag catgtttcta agggtaaatt tatgataggt atatgtctag
    23881 gaatgcaatt actttatgaa aaaagttatg agtatggaga atatgaagga ttaggactta
    23941 taaaaggaag tattgataaa ctggatataa gtttaaaagt gccacatatg ggatggaata
    24001 atctaaaatt taataaggca aatgatgata tacttaaata tataaatgaa gatgattatg
    24061 tatacttcgt tcactcatat tatgcaaatt catcaaatga agaactaatt gcattttcag
    24121 aatatgaaaa gaaaatccct gctattgtta gaaaaggcaa tgtatatggt atacaatttc
    24181 atcctgaaaa aagtggagaa gtagggttaa atatattaag agcatatggg gagatgataa
    24241 aatgataata tttccagcaa tagatataaa agataataag tgtgtaagac tcacacaagg
    24301 agaatttgac aaagtaaatg tatattatga taatccatta gaagtagcat ataaatggaa
    24361 aaatgaagga gcagaatata tacatatagt agatttaaat ggtgctagaa gtgaatttgg
    24421 tgtaaataca aaaataattg aggacatagc aaacaatata gatataccta ttcaagttgg
    24481 cggtggagtt agggataagg aaaaagtcaa aagtttaata aatgctggtg ttactagagt
    24541 aatattaggc agtatagcga ttgaaaattt gaatttagtt gaagaattgg tcaatgaata
    24601 taaagagaaa attgtagttt ctatagatgc taaagatgga aaagtagcag ttaggggatg
    24661 ggaagttgta agcaatgtag actcattaac attatgtaaa caacttgaaa agataggtgt
    24721 acaaactatt gtttatacag atatatcaaa agatgggatg ttgcaaggtc caaattttga
    24781 catatatgaa agaatagcaa aggaaacatc actaaatgtt attgcttctg gaggcgtaac
    24841 ttctatagaa gacgtaaaaa gactaaaagc tatgaactta tatggtgcaa taataggtaa
    24901 agcgctttat gataaaaaga tagactttaa ggaggcacaa caattatgct tactaggaga
    24961 ataatacctt gtctagatgt gagaaatgga agagttgtaa aggggaaaaa atttaaagat
    25021 atagtagatg ttgatagtcc agaagtactt ggaaaatttt atagtgattg tggtgcagat
    25081 gaacttgtat tctatgatat aactgcatca aatgaagaga gaaagacatc tttagaattt
    25141 gtgacaaaag ttgcagaaaa tataaatata ccattttgtg ttggtggagg agtaaataaa
    25201 ttagaagatt tcactgatat tttaagaaaa ggtgctgata aagtttctat aaattcatca
    25261 gcagtcaaaa atcctgaatt aataagggaa gcttcattaa aatttggagc acaatgtgtt
    25321 gttttatcga tagatgcaaa gaaaaatgaa gagggttcat ggagcgtata cgtaaaaggt
    25381 ggaagagaaa aaactaatct ggatgcaatt gaatgggctg ttaaaggtgt agaacttgga
    25441 gcaggagaaa tcgttgtaaa tagtatggat gaagatggaa tgaaaaatgg atatgatata
    25501 gaattattat caaagataac ttctttagta aatgtacctg ttatagcatc tggaggcgct
    25561 ggaaaaaagg aagattttta tgaggcggtt aataaatcca atgtagatgg aattttagca
    25621 gcatctgttt ttcattttgg cgagataaaa ataaacgatt taaagaaata tttaaaagac
    25681 atgggtgtag aagtaagatt ataagttaaa tactaaaagg agattagaaa tatggataat
    25741 aagtgtaaca atgtatacag tgatgaagta gagaaattta taagaagtat aaagtttgat
    25801 gataaagggt tagtccctgt tgttgttcaa gaggtagtta gcaaagatgt actgatgtta
    25861 gcatatatga ataaagatgc tataaagaaa accttaaaag ataaagtagc ttgctatttt
    25921 agtagaagta gacaagaact ttgggttaaa ggtgagacat ctggtaatac tcaaaaagta
    25981 gttaagatgt cttatgattg tgatgtagat actatactac tttttgttga acaaactggt
    26041 gtagcttgtc atacaggcaa ttattcttgt ttttacagag acttgtttga tgatagttca
    26101 aaaatggagc ttgaagtaca aacaaatata ttgaaagaat tatatgattt aatcaatgaa
    26161 agaaaaaata atccagttga aggttcttat actaattatc tttttgaaaa aggaatagat
    26221 aagattctta aaaaagtagg tgaagagagt agtgaggtaa ttatagcatc aaaaaatacc
    26281 gataaaagtg aacttattta cgaaattagc gatttagtat atcatacatt ggttttaatg
    26341 atagaaaaag gtgttgaaat tgatgaaata aaaaaagaat tacttaaaag aagaaaatag
    26401 aataagatag attaatgggt aataagaaaa tataccgctt ttaataaaaa gtggtatatt
    26461 ttttatttta tattttgatt tatagaataa tattt
//
LOCUS       DAEQCW010000046        26405 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.046, whole genome shotgun sequence.
ACCESSION   DAEQCW010000046 DAEQCW010000000
VERSION     DAEQCW010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26405)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26405)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26405
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.046"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            67..696
                     /locus_tag="KRO40_001972"
     CDS             67..696
                     /locus_tag="KRO40_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2092792.1"
                     /translation="MSIKERRKNEKEEMKKKIMDASIEIINQHGYENLSIRKIATKIE
                     YSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSSLPIDKQIIEIMTSFIKT
                     LSSEPEMAKSIMHSRMNIIFASENTNNTPSNNGIKMLDKFLSIGIEQGIFKKNIDKSS
                     WMLISALLGFVLCVVENKLYSLHNFSQLIENFLDILVGGLYNENSQQGY"
     gene            671..1075
                     /locus_tag="KRO40_001973"
     CDS             671..1075
                     /locus_tag="KRO40_001973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FMN-binding protein"
                     /protein_id="HBH2092793.1"
                     /translation="MKIRNKATNKKKKYVKISIALFFVFICIIIVIVSNLKPENLVVK
                     DIDINNVKNGIYTGSADNNLVKATVSVEVNNGKIQNINILKHDHLLGKPAEKITTSII
                     KQQSLDVDAITSATYSSNTIRKAVENALRKGE"
     gene            1078..1554
                     /locus_tag="KRO40_001974"
     CDS             1078..1554
                     /locus_tag="KRO40_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin domain-containing protein"
                     /protein_id="HBH2092794.1"
                     /translation="MNTIIIYSSKYGCTKDCANILKNKLSDNVTIVDINNNNNKIELS
                     KFDKIIIGSSIYVGSVSKKIQVLCNDNVELLNKKQVGIFLCCGFSEQADKYLKSNFPS
                     SLLESANAIGIFGSEARLEKMKFLDKLIMKAVSKGNYDSFRISQDNIDNFLINLNS"
     gene            2126..2791
                     /locus_tag="KRO40_001975"
     CDS             2126..2791
                     /locus_tag="KRO40_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HBH2092795.1"
                     /translation="MIKLIGILIVVIGFILKIDTLFTVLLAGVATGIVAGLDFNQIFT
                     ILGDSFVSNRGVSLFILTLPVIGVLERYGLKQRAVSLIEKLKRLTTGKVLTIYMIARQ
                     IAGALSIRMSGHPQFVRPLVNPMAQAAGLSNSDELKESDEEAIKALSAASENYGNFYG
                     QNLFAGSSGVLLIASTLTQFGYNVTGLNIVKASTIMAVIALVVATIQFTLYDKKLNKS
                     HKK"
     gene            2813..3745
                     /locus_tag="KRO40_001976"
     CDS             2813..3745
                     /locus_tag="KRO40_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HBH2092796.1"
                     /translation="MQNFINISLEIFYALMGFLMIVIAYKSFTTINNNKKYGTSLFWI
                     LISLPFIFGRLIPANIIGIILILSSLLTLSKQVVFAKYEEPDENFGKEQADKLKNKIF
                     IPSLILAFAAVVVAMSLSNFDNSSQFAIGVGSIIALISALIITKAKPATSVQDGSRLL
                     QQMGPASMLPQLLVALGALFTQAGVGEVISTMISGVVPADSRLFGVIAYVLGMVIFTM
                     IMGNAFAAFSVITAGIGIPFVLSQGGNPAIIGALALTAGYCGTLLTPMAANFNIVPAA
                     LLECKNDYIVIKYQAPVALVLIIAHILVMYFLGF"
     gene            3766..4407
                     /gene="pcp"
                     /locus_tag="KRO40_001977"
     CDS             3766..4407
                     /gene="pcp"
                     /locus_tag="KRO40_001977"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HBH2092797.1"
                     /translation="MKILLTGFDPFGGEPINPAQEAVERVNNNINGAEIIKITIPTVM
                     TKSVEAIDKAIQEHNPDIVISVGQAGGRFDITPERVAINIDDFRIKDNEGNQVIDTII
                     KEDGEPAYFSKLPVKAMVKHMNENKIPASVSNTAGTFVCNHVMYGILYMIDKKYPNIR
                     GGFIHIPYTTSQVIDKKNTPFMSLEEIVKGLELAIEACIIYKEDVKEIGGEIS"
     gene            complement(4527..4859)
                     /locus_tag="KRO40_001978"
     CDS             complement(4527..4859)
                     /locus_tag="KRO40_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092798.1"
                     /translation="MSIDCISNTDLSETGFSYTLSLISGKYKMIILYCLVEFEVVRYN
                     ALKRYINTISYKTLSLSLKELEADNLIIRTEYPQIPPKVEYSLSERGKSLIPILDAMC
                     EWGERNRP"
     gene            5125..5745
                     /locus_tag="KRO40_001979"
     CDS             5125..5745
                     /locus_tag="KRO40_001979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2092799.1"
                     /translation="MKVLLINGSPNQYGCTYTALNEITKVLSKHDIKTEILYLGKETI
                     PGCISCASCFETGKCIRNDKVNELIEDLDNIDGIIIGSPVYFSSATGQLTSFLDRLFF
                     IAGSRMATKLGASVVSCRRGGASATFDQLNKYFSISNMPIVSSQYWNQVHGFTPEDVM
                     KDEEGLQTMRTLGENMAWLLKCISAGKKAGIKEPQYEETIMTNFIK"
     gene            complement(6070..6894)
                     /locus_tag="KRO40_001980"
     CDS             complement(6070..6894)
                     /locus_tag="KRO40_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraX"
                     /protein_id="HBH2092800.1"
                     /translation="MDFFKKGISGFTIKILALIFMTFDHIAAFMPQTMQIPIWFHWVG
                     RISAPLFIFMAVEGFYHTSNRKKYISRLYIWSVIMAIGNQIINNVFSHPEGAIIINNI
                     FSTLFLIAIYLQAIEFIKKFRKEKEIKYFIIGLLMIIIPIILGIFTVALLFKVTNRVI
                     ALFMILVPVPFLVEGGPIWIILGIIFYLCRGKKFSLSICYVLMCIFIFTTMSNGDYSL
                     KNSILQNYQWMMIASLPLMLLYNGEKGKSMKYLFYLYYPIHVYILYILGIYLINGF"
     gene            complement(6905..8308)
                     /locus_tag="KRO40_001981"
     CDS             complement(6905..8308)
                     /locus_tag="KRO40_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092801.1"
                     /translation="MKWKITRNFIFTIVFVAISVVIINIISILYVISTNSFFKVVDSG
                     NNPEEFARSFEKDLYEKDGEFKLSKIGAEKLEKSNSWIQVLNDLGEEVYGVNVPKDTP
                     KKYTPFQMVNNYKYIETKYVNFVLEKYLNKKHLNIIVGIPSRDISRIILTYSQNNIKK
                     TLNKVIIITLVIDSVVALGVGYLFSRKLTKPISSVLWSIETMANGNYSLYLKDRGIYE
                     EVFKNINMLADTLRVNEVERKENEELREEWLANITHDIKTPLASIQGYAEIINDKDYE
                     FEEDEIQEYTEIIYNKSKYIKDLVDDLNLSTRLKNNTIVLDKKKINLVSLVRNIIIDI
                     LNDNRYKNRNIEFESNEDLIEVYVDSILFRRAITNLIFNSIVHNSEGTLISVEIVKKD
                     NIEIIIKDNGIGISKSDLKHIFKKYYRGTNTGEMHKGSGLGMAISKEIIEIHKGKIYV
                     SSEIGIGTKIIIEIKQN"
     gene            complement(8312..9037)
                     /locus_tag="KRO40_001982"
     CDS             complement(8312..9037)
                     /locus_tag="KRO40_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012450879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092802.1"
                     /translation="MENRVLIIDDEVEILKLLETVLKKEGLNNIYTAKTKKEGLELFK
                     SINPDLIVLDIMLPDGEGYDICKEIRKTSNSPIIFLSAKTEELDKLLGLAIGGDDYVT
                     KPFSPKEVAFRVKAHLRRLSYFSDAQNESKNLNNNEEKIISFGPYILNESRAELIKDG
                     KSIGLSAKELKILSLFAHNQNQIISKEKLWDKVWGEDYVGFDNTIMVHIRKIREKLED
                     NPSKPEYILTIKGLGYKLAVKED"
     gene            complement(9149..9922)
                     /locus_tag="KRO40_001983"
     CDS             complement(9149..9922)
                     /locus_tag="KRO40_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092803.1"
                     /translation="MMYLVKAEMIKILKSKSVWIIWLFLIVFGFFLIRKFDVLDTYAD
                     IFYKIEGSIPLIGLIMFIITSGNYIKEYDSNMTGLINTTKKGKKSVVLSKLVANGLIL
                     SIINISFILLVGIRGFSFFDFKNLNESIHNLWYFGNSNLNLTVIQMYIIVILTTIFAS
                     FIFAQIGLTLSSIFKSAVIPFILGGLIMAIPYFSVGFIPDKAIKFMSVTPNWIMMSQQ
                     MVKYNVPSILIVFSIVISIILMIVLTKITYENFTSSKRF"
     gene            complement(9928..10815)
                     /locus_tag="KRO40_001984"
     CDS             complement(9928..10815)
                     /locus_tag="KRO40_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092804.1"
                     /translation="MNKLEIENLSKIYGKKVANDKITVTLENGVYGLLGPNGAGKSTL
                     MKQITTLIKPDEGQILYNGEDIFKMDADYRNILGYLPQEFGVYKNFTAKEFLQYIGAL
                     KGLRGKYLNSKIGELLDLVGLYDVRNKSIGKFSGGMKRRVGIAQVLLNDPKIIVLDEP
                     TAGLDPQERARFRNLIAKMSRDKIIILSTHIISDIESVAKETIMIKDGKLLMKGTHKD
                     ILSHMENKVYNVQVKNECEVDDIQSKYKVVSIQSDIDSIVLRIVSEDIPSEDNIQPVQ
                     AKFEDVYMFYFDLEDAREV"
     gene            complement(10829..11851)
                     /locus_tag="KRO40_001985"
     CDS             complement(10829..11851)
                     /locus_tag="KRO40_001985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092805.1"
                     /translation="MVNWEIKKLAKSKSMFISLGILVLILMISIFIAPVLETESYYID
                     KEKGRIEDTRSGIDVGNEKFQNKINVLKQFSNQTDTGEFSKKIELMSKKKLDNLSVNE
                     YKDISFWKVFNYRVTNSLINVGMLIIISIIISNIYVDEVVTSVKDIILSSKEKKKALK
                     SKIFVALLVPLVIYSVYLMGIFIITCMQQGVPVNGDLESFRIVDNVVALKTNLSITKY
                     VILNIGIELLMFEGWAMIAIFGSFISKSSISSISFFIFIISITKIMSVIHILPKKLLS
                     VVSNVNYYDLIFGFNKIIGNYLGDIMIFKVNIDIVNIAIGLLMAILIGAMSLCFLVIK
                     SDYISR"
     gene            12426..12602
                     /locus_tag="KRO40_001986"
     CDS             12426..12602
                     /locus_tag="KRO40_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092806.1"
                     /translation="MFIGEIDKCTHILTAYISSSYDYCNFLDTQLDDFISEYGETVVE
                     TCLHQVLLLVSRYN"
     gene            complement(13705..14289)
                     /locus_tag="KRO40_001987"
     CDS             complement(13705..14289)
                     /locus_tag="KRO40_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH2092807.1"
                     /translation="MTEREKMLAGELYDCGDIELLTQWHKAKDLVRDYNQTDSSDLEK
                     KEKILNELLGGKGKNLWITAPYYVDYGNNIYFGNNCEVNMNCTFLDDNKIIIGDNALI
                     APNVQIYTAFHPTNAGDRFGNAKEDGSFEFCKTQTAPVTIGDNVWIGGGAIIMPGVTI
                     GDNVVIGAGSIVTKDIPSNMIAYGNPCRIIRENK"
     gene            complement(14611..16455)
                     /locus_tag="KRO40_001988"
     CDS             complement(14611..16455)
                     /locus_tag="KRO40_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBH2092808.1"
                     /translation="MQKRILRNFIFTGKNILSKLVFIIKYNFSTLILFELFHKGLALF
                     FIWPSIRYIFDILIKSLHIVYLNMDNFIKVLTNPMSIVLIILSVIILAFYAFFEFTSV
                     IICFNKSIKYEKIGLFELFKISFENSIKLLYPKNILLFIFVILIIPLVNTVLISGFIG
                     KIQIPEYILDYIKSDIILNIIYMIFLLIIYISVIRWIFSIHEITLNTENFKRARKESV
                     NLIKGKIIRTIIYSLILSLVVAIIGYAIYHSGIIFIGIWTKYCTDMEFLKNVFINRCI
                     AFEEYFRLILSIFIFILDIGFISATYYQYKGVSISKNNIKKEKKSISKIVFNLVLILL
                     ISYIESVAFSSHINGMFNTSFSFYTTAIAHRAGAEMAPENTLAAIEEASHAKADYAEI
                     DVQETKDGELIVLHDSNFKRTTGVDKNVWDVNYNEVKTYDAGSFYYYGKGYYDEKFVG
                     EKIPTLKEKIKYSKGKVKLLIEIKLNGHEKGDVVKKVVQLIKENNFENQCIVASMDKT
                     ILQKVKKLDENLLTCYFMAIAYGDFSKLNYVDIYGIESTFVNKTVVEKIHKMNKKIFV
                     WTVNSDSLIEKMLDLNVDSIITDNPYLIESAIYWKKNGFISQVSDYLF"
     gene            complement(16749..17711)
                     /locus_tag="KRO40_001989"
     CDS             complement(16749..17711)
                     /locus_tag="KRO40_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase family protein"
                     /protein_id="HBH2092809.1"
                     /translation="MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFS
                     KKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTGLAIACACKGYKFIACMSKGNSM
                     ERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEA
                     CNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETA
                     AIYSGKEITDQGHKIQGGGYSMDLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFA
                     GFSSGANVCAAIKLLKSSEKGKNIVLTLNDSGLKYLSTDLYEEL"
     gene            17902..18453
                     /locus_tag="KRO40_001990"
     CDS             17902..18453
                     /locus_tag="KRO40_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092810.1"
                     /translation="MSINTVIAKNLNRLRNERNLSLGQLAELSGVSKVMLSQIEKGDS
                     NPTVNTIWKIASGLNVPYTAILEQPQNETFIVSKTDIDVQVSENKDYRLYCYYPNTPT
                     RNFELFQMELEEGHSYTSVGHSEKSQEYIMIIEGQLKLEVNDSIYQLRENDSICFSAE
                     SIHTYHNQGEKTLKAVIINYYPV"
     gene            complement(18992..19279)
                     /locus_tag="KRO40_001991"
     CDS             complement(18992..19279)
                     /locus_tag="KRO40_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092811.1"
                     /translation="MKKFLYALYSFIVIIANFRLKEKNYNFILLAIFFILLLIQNGVL
                     KTGYQNRATFYQDNYFNGEDKNDKIKFMTIKIFIFLSLPLCFNILFNYLTS"
     repeat_region   19688..20903
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=19688..19716
                     /rpt_unit_seq="atttacataccacttagttaatataaaac"
     gene            21550..22821
                     /locus_tag="KRO40_001992"
     CDS             21550..22821
                     /locus_tag="KRO40_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH2092812.1"
                     /translation="MLKVLKGNIIFTKTSETFTVFENSYIILEKGKVKGIFKEIPKEY
                     KNLKVVDYTDKLIIPGMNDLHAHASQFKNLGMAMDKELLPWLETYTFPEESNYKDIEY
                     ATKMYKKFVKELWKSGTTRIAVFATVHKEASMKLMDIFKEVGLGAYVGKVNMNMNCPD
                     TLLENTQDSITDTEEIINKYSDTDSIVKPIITPRFIPSCTSELLKGLGDLCLKYNIPI
                     QSHLSENYDEIEWVRSLEPESKFYGDAYNRYNLFGQTPTLMAHCVHCSQDEIDLMREN
                     NVMAVHCPASNFNVGSGAMPIRKLIDNNIRLALGSDISGGHTLSIFKAMVSAIQLSKL
                     YWVNSGKKYNFLSLSETFYIATKSGGSFFGKVGSFEEGYDFDALIIDDSNLNHDNYSI
                     LERLERFIYVGDDRNIIHRYVCGKLIEEPNI"
     gene            23405..23722
                     /locus_tag="KRO40_001993"
     CDS             23405..23722
                     /locus_tag="KRO40_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine/purine nucleoside phosphorylase"
                     /protein_id="HBH2092813.1"
                     /translation="MSEFKNVTAVKKANVYFDGKVSSRVIILPNGERKTLGLMLPGEY
                     TFSTREEEIMEMLAGSMDVKLPGSNEFVTYKEGQKFNVPSDSSFDLKVNEVVDYCCSY
                     IAD"
     gene            complement(23808..26165)
                     /locus_tag="KRO40_001994"
     CDS             complement(23808..26165)
                     /locus_tag="KRO40_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="HBH2092814.1"
                     /translation="MDKVNLERYSCDINVGLNKNQLQSRIDDNLINAFDNGKTKTYKQ
                     IFKDNIFTLFNLINIVLVCLLVSVGSFKNTLFIFIAVINTIIGVIQEIRAKRLLDNLS
                     VIVSNKVSVIREKEKKEIDVQELVLDDIMILKTGNQICADSKVLNGKLEVNESLVTGE
                     SDIIIKNKGDFLYSGSFVVSGEAFVRVENIGKDNYANKIANDAKISKKHNSQLRNSLN
                     AILKIVGIIIIPLGIILFAKQHFGNGDSIATSVVGTVAAVNGMIPEGLTLLTSIALAV
                     GTIKLASHKTLVQELYCVETLARVDTLCLDKTGTITEGKMQVDDIVMLEEVDINEIMG
                     NICNSLKDDNATLNAIRDKYNVLDTYKAKNLIPFSSERKYSGVTFENKGTYLLGAFEF
                     IFKEKNKKLRIEVERYSKKGNRVIVLAHSDSYMEDDNIPEDIKPLAFILILDKIRDEA
                     KETLEFFYNEGVDIKIISGDNPITVSEVARKAGLKTASNFIDATTLKNDSDIYKAVDK
                     YSVFGRVSPQQKKQMILALKKQNHTVAMTGDGVNDVLALKEADCSIAMASGSDVTKNV
                     SNLVLLDSNFASMPKVVMEGRKVINNIQRASSLFLVKTIFSFFLSLLTLFFFSRQYPF
                     VPIQLSLIGAVTVGIPSFFLALEANKSRISGNFLLNILKNALPGALCVTVNVIIVYNI
                     VEYLGYSSSVFSTMCAILTGVCGLLILRQQCLPFNKERLFLIVSMTIAFVIGILFLGG
                     LFSFVALSRELILITMALAILMPIMIKVMLFVLDEILETIVPDLN"
BASE COUNT         9671 a         3841 c         2907 g         9986 t
ORIGIN      
        1 attaaaatta aattatacaa taacagtgta aattaactta acaccgttaa gcaaagaggt
       61 gattatatga gtatcaaaga aagacgtaaa aatgaaaaag aagaaatgaa gaaaaagatt
      121 atggatgcta gcatcgaaat tataaaccaa catggatatg aaaatttatc aataagaaaa
      181 attgctacaa aaatagaata ttctccaact acaatttatc tttactacaa agacaaagca
      241 gagattatca gcgatatgac caataaactt tataacacag tagaaagtaa tgccattgac
      301 attatgaata attgctcatc actaccaata gataaacaaa tcatagaaat tatgactagc
      361 tttataaaaa ctctttctag tgaaccagag atggcaaaat ctatcatgca tagtagaatg
      421 aatattatat ttgcatctga aaatacaaac aatacgccta gcaataatgg tataaaaatg
      481 cttgataaat tcctttccat tggaattgaa caaggaatat tcaaaaaaaa tatagataaa
      541 agctcatgga tgcttataag tgcattgtta ggattcgttt tatgtgttgt tgaaaataaa
      601 ctatattctt tacataattt ttctcaactt atagaaaatt tcttagatat tttagtggga
      661 ggactttaca atgaaaattc gcaacaaggc tactaataaa aagaaaaaat atgtaaaaat
      721 atctattgct ctattctttg tatttatatg cattattatt gtaattgtaa gcaacttaaa
      781 gccagaaaac ttggtagtaa aagatataga tattaataat gttaaaaatg gcatttatac
      841 tggaagtgct gataataact tggtaaaagc tactgtgtct gttgaagtta ataatggtaa
      901 aatccaaaat attaatatct taaaacacga ccatctttta ggtaaacctg ctgaaaaaat
      961 tacaacaagt attattaaac aacagtcttt agatgtggat gctataactt ctgcaactta
     1021 tagcagtaat actatacgaa aagctgtaga aaatgcttta agaaagggag aataattatg
     1081 aatactatta ttatatattc aagtaaatat ggttgtacaa aagactgtgc aaatatacta
     1141 aaaaataaac tatcagataa tgtcactatt gttgatatta ataataataa taataaaatt
     1201 gagttatcaa aatttgataa aattattatt ggaagttcta tatatgttgg ttcagtttca
     1261 aaaaaaatac aggtgctatg taatgataat gtagagttat taaacaaaaa acaagttggc
     1321 attttccttt gctgtggctt ttctgaacaa gcagataaat atttaaaatc aaattttcca
     1381 tcatccttat tagaaagtgc aaatgctatt ggaatttttg gtagtgaagc tcgattagaa
     1441 aaaatgaaat ttttagataa acttattatg aaggctgttt caaaaggtaa ttatgacagt
     1501 tttagaatat cacaggataa tatagataat tttttaataa atcttaatag ctaaaataaa
     1561 gctaattatt tctatgataa attcttttat ttataagtaa tattgctcaa aatagtcttt
     1621 aaactttatc aaaattttat ttttcttagt gaaatctaat gaaactagca cttaatatat
     1681 gctttattaa tcataacaaa tatgttttat taatcataac aaaaagagag tgtctaatga
     1741 actaaaaaat tcattagaca ctctcttttt gtatgaaatc aaatatattt ttatcatttc
     1801 aacagagaaa aatacacttg tctctatgtt tggcacattc tctttttata atataatgtt
     1861 taatttaaaa ctactatttc aaatattgac atatacttaa actatagact tacaaaatca
     1921 attcatatta gcttaaaata taatctttgt tattcaaatt cctatacaca accattattt
     1981 actttgatac tttaaaacat cttccctatt ttttattaaa ttttataata atagtcctat
     2041 taacgcaaat actataaaaa gagtttaact ttatccatta aataaattta aattaaaaca
     2101 tatagaaatg gaaggagaac aatttatgat aaaactaatc ggtatattga tagttgtaat
     2161 tggatttata cttaaaattg acacactatt tactgtatta ttagcaggag tggcaacagg
     2221 aattgttgca ggattagatt ttaatcaaat ttttacaatt ttaggagatt cttttgtctc
     2281 aaacagaggt gtatcattat tcatattaac attgccagtg atcggtgtat tagaaagata
     2341 tggtttaaaa caaagagctg tttctttaat agaaaaatta aaaagactta caacaggaaa
     2401 agtacttact atatacatga tagctagaca aatagctggt gctctatcaa taagaatgag
     2461 tggacatcct caatttgtaa gaccacttgt taatcctatg gcacaagctg ctggtttaag
     2521 taatagtgat gagctaaaag aatcggatga agaagccata aaggcattat ctgctgcatc
     2581 agaaaactat ggaaattttt atggtcaaaa cttatttgca ggtagtagtg gagtattact
     2641 tatagcatct actctgactc aatttggata caatgtaact ggacttaata ttgtaaaggc
     2701 tagtactatt atggcagtaa tagcacttgt agtggctaca atccagttta ccttatatga
     2761 taaaaaatta aacaaaagtc ataaaaaata gttttattta ggaggaataa aaatgcaaaa
     2821 ttttataaac atatcattag aaatctttta cgcactaatg ggatttttaa tgattgttat
     2881 agcatataag tcttttacta ccataaataa caataagaaa tatggtacat cattattttg
     2941 gatacttata tcactgccat tcatatttgg tagattgatt ccagccaata taataggaat
     3001 aatattaata ttatctagtt tattaacact ttctaaacaa gttgtatttg caaagtatga
     3061 agaaccagat gaaaattttg gaaaagaaca agcagacaaa cttaaaaata aaatatttat
     3121 accatcatta atattagcat ttgctgcagt agtagtagct atgagccttt ctaattttga
     3181 taattcttct caatttgcaa taggtgtggg ttcaataatt gcattaatat cagcccttat
     3241 aataactaag gcaaaacctg ctacatcagt tcaagatggc tcaagattac ttcaacaaat
     3301 gggacctgct agtatgttac cacaactttt agttgcattg ggagctttat ttactcaagc
     3361 cggagtcggt gaagttattt caaccatgat atctggtgta gtccctgctg atagcagatt
     3421 atttggtgtt atagcttatg tattaggtat ggttatattt accatgataa tgggaaatgc
     3481 atttgccgca ttttcagtca taacggcagg aattggtatt ccttttgtat tgtctcaagg
     3541 tggaaatcct gctataattg gagcattagc attaacagca ggatattgtg gaactctact
     3601 tactccaatg gctgctaatt ttaatatagt tccagcagcc ttgctagaat gtaaaaatga
     3661 ttatattgtt ataaaatatc aagctccagt tgctttggta ttaattatag cccacatatt
     3721 agtaatgtac tttttaggat tttaatataa ttaggaggta aaataatgaa aattttgtta
     3781 acaggatttg acccatttgg tggagaacca ataaacccag ctcaagaagc agttgaaagg
     3841 gtcaataata atataaatgg tgcagaaatc ataaagataa ctataccaac agttatgaca
     3901 aaatctgttg aagctataga taaagctatt caagagcaca atccagatat agtaatatca
     3961 gttggacaag ctggaggtag atttgacatt acacctgaga gagttgctat aaatatagat
     4021 gattttagaa taaaagataa tgagggtaac caggttatag atactattat aaaagaagat
     4081 ggtgaacctg catatttttc aaaattgcct gtaaaagcta tggtaaaaca tatgaatgaa
     4141 aataaaattc cagctagtgt ttcaaacact gcaggaacat ttgtttgcaa tcatgtgatg
     4201 tatggaattc tttatatgat agacaagaaa tatcctaata taaggggtgg atttatacac
     4261 atcccatata caacttcaca agtaatagat aaaaaaaata caccattcat gtctttagaa
     4321 gaaatagtaa aaggcttaga attagctata gaagcttgta ttatatataa agaagatgta
     4381 aaagaaattg gtggtgaaat ttcataataa attttttagt atttttataa attaaaaata
     4441 ctaactatta atttaaatat agactgtgag tagattattc aaacaatttt actcacagtc
     4501 tttttatggt atctacagat acaaaattaa ggtctattcc tctctcccca ctcacacatt
     4561 gcatctaaaa ttggaatcag agattttccc ctttctgata gactatattc taccttagga
     4621 ggtatttgag gatattcagt acgaataatc aagttatctg cttctaattc ttttaatgat
     4681 aaactcaaag ttttatagga gatagtattt atataacgtt ttaatgcatt atatcttaca
     4741 acttcaaatt ctacaagaca gtaaagaatt atcatcttat atttaccact aatcagtgaa
     4801 agtgtataac taaatcctgt ttcacttaaa tctgtatttg atatacagtc tatactcata
     4861 tattacactc tccttttggt tagtattgaa caaaaatgtg cgtacttgtt tttagaataa
     4921 tttataataa aattatagtg taagaataat tgaaagtcaa ttttataata ggaggtgtat
     4981 ttactaaaaa aaaagttatt ttaaatagga ttctaagatt agacatttct atataaattg
     5041 ataatattca tgaaaatcct attttataaa aaataatatc tcttagaaaa tctattaaat
     5101 aaaattcatg ggaggaaatt tataatgaaa gttttattga taaacggtag cccaaaccaa
     5161 tatggatgta cttatacagc actaaatgag attactaaag tattgagtaa acacgatatt
     5221 aaaacagaaa tactgtattt aggtaaagaa acaatcccag gatgtattag ttgcgcatcc
     5281 tgttttgaaa ctggaaaatg tattcgaaat gataaagtta atgaattgat tgaagatctt
     5341 gataatattg atggtattat tattggttct cctgtttact tttctagtgc aactggtcaa
     5401 ttaacttctt ttcttgaccg tctatttttc atagctggaa gtcgcatggc tacaaaatta
     5461 ggtgcttcag ttgtgtcatg tagacgtggt ggtgcaagtg caacatttga ccaactaaat
     5521 aaatattttt caatcagcaa tatgcctatt gtatcatcac agtattggaa tcaggtacat
     5581 ggctttactc cagaggatgt tatgaaggat gaagaaggat tacagactat gcgaactcta
     5641 ggagaaaata tggcatggct tcttaagtgt atatcagcag gtaaaaaagc tggaattaaa
     5701 gaaccacaat atgaagaaac aattatgact aattttataa aataaataaa aaatgcacta
     5761 atattaatta aaacaaaaca ctaatttata aataaaataa gcataaatgt aggataaaaa
     5821 gcactaaaac agaggtattg aattttatat caaacctctg ttttattatt acattaataa
     5881 ccaaaccatg tataacatca tatatttcta aataaattat aatattatat tctaatgtta
     5941 ttgaaattac aataactgaa tttctgctca taaatttaaa tattctacaa atctcatcta
     6001 aataacaatt ttaatagacc taaaacaatc ctcatattgt tcattttgta ttaaaaatat
     6061 cacttacaat caaaaaccat ttattaagta tattcctaag atatacaata tatatacatg
     6121 gattggatag tataaataaa ataaatactt catactcttc cctttttctc cattgtaaag
     6181 taacattaaa ggtagagaag caatcatcat ccattggtaa ttttgtaaaa tagaattttt
     6241 taaactataa tctccatttg acattgttgt aaatataaat atacacatta aaacataaca
     6301 aatactcaaa ctgaactttt tccctctaca caaataaaaa ataatcccaa gtataatcca
     6361 aattggtcca ccttctacta aaaatggtac tggtaccaaa atcataaata aagcaataac
     6421 tctgttagtg actttaaaaa gtaaagctac tgtaaatatt cctaaaatta taggaatgat
     6481 tatcatcaat aatcctataa taaaatattt aatttctttc tcttttctaa atttctttat
     6541 aaactctatt gcttgtaaat aaatcgctat taaaaataat gttgaaaaaa tgttatttat
     6601 aattatagct ccttctggat gtgaaaatac attattaatt atttgatttc ctatagccat
     6661 aataacagac caaatataca atctacttat atattttttt ctgttactag tgtgataaaa
     6721 tccttcaaca gccatgaata taaacagtgg tgctgatatt ctgcctaccc aatgaaacca
     6781 aattggtatt tgcattgttt gtggcataaa tgctgctata tggtcaaatg tcataaatat
     6841 taatgctaaa atcttaatag taaacccact tatacctttt ttaaaaaaat ccatatcata
     6901 tctcctaatt ttgttttatc tctataataa tttttgttcc tattccaatt tcactactta
     6961 cataaatttt acctttatga atctctatta tttctttaga aatagccata ccaagacctg
     7021 aacctttatg catctcacct gtattagtac ctctataata ttttttaaaa atatgtttca
     7081 aatcactttt gcttattcca attccattat cttttattat aatttctata ttatcttttt
     7141 ttacaatttc tacacttatc aaagttcctt cgctattatg aactattgaa ttaaatataa
     7201 gattggttat agcccttctg aataagattg aatctacata tacttcaatt aaatcttcat
     7261 tgctttcaaa ttcaatattc ctatttttat atctattatc atttaaaata tcaattatta
     7321 tatttctgac taaactgact aaatttattt ttttcttgtc cagaactata gtattatttt
     7381 ttaatcgagt agataaattt aaatcatcaa ctaaatcttt tatatactta gacttattat
     7441 atataatttc tgtatactct tgtatttcat cttcttcaaa ctcataatct ttgtcattaa
     7501 ttatctctgc atacccttgt atagatgcta gaggtgtctt tatatcatgt gttatatttg
     7561 ccagccattc ctctctcaac tcttcatttt cttttctctc aacttcattt actcttaaag
     7621 tatcagctaa catatttata tttttaaaaa cttcttcata tatacctctg tccttaagat
     7681 ataaactata atttccatta gccatagtct caatactcca tagtacgctt gaaattggtt
     7741 ttgtaagttt tctactaaat aaatatccta cgcctaaagc taccacgcta tcaattacta
     7801 gtgttataat gataacttta tttaaagttt ttttaatgtt attttgagaa taggttaaaa
     7861 ttattcttga tatatctcta ctaggtatac ctactattat gtttaaatgc tttttgttta
     7921 aatatttttc tagtacaaaa ttaacatact ttgtttctat atacttgtaa ttattcacca
     7981 tttgaaaggg tgtatatttt ttgggagtat cctttggcac atttactcca taaacttcct
     8041 ctcctaaatc atttaaaacc tgtatccagg aatttgattt ttctaatttt tcagctccaa
     8101 tcttagatag tttaaattct ccatcttttt catataaatc tttttcaaaa gaacgtgcaa
     8161 attcttcagg attatttcca gaatctacaa ctttaaaaaa gctattagtt gaaatcacat
     8221 acaatataga tatgatattt ataattacta ctgatatagc tacaaacaca attgtaaata
     8281 taaaatttct agtaatcttc cacttcatat tctaatcttc ctttactgct aatttatatc
     8341 caagaccttt tattgtcaga atatattcag gttttgaagg attatcctct aatttttccc
     8401 taatttttct tatatgaacc attatagtat tgtcaaatcc aacataatct tctccccaca
     8461 ctttatccca tagtttttct ttacttataa tttgattttg attatgtgca aataaagata
     8521 ggatttttag ttcctttgca gacagtccta tagattttcc atcttttata agttctgccc
     8581 tactttcatt taatatatat gggccaaatg atataatttt ttcttcatta ttatttagat
     8641 ttttactttc gttttgagca tcactaaaat aacttaatct tctcaaatgc gctttaactc
     8701 taaaagccac ttccttaggg ctaaaaggtt ttgtaacata atcatctcct ccaatcgcta
     8761 gtccaagtaa cttatctaat tcttcggttt tagctgataa aaatattatt ggagaattgg
     8821 aggtttttct tatttcttta caaatatcat aaccttcgcc atctggtaac ataatatcca
     8881 atacaatcaa atcaggattg atacttttaa ataattctaa tccttctttt ttagtttttg
     8941 cagtatatat attattaaga ccctcttttt ttaggacagt ttctaaaagc ttcaatattt
     9001 ctacttcatc atctattatt aaaacacgat tttccataaa caacctcctg taataattta
     9061 catatatatt agcatatatt ttatctaaaa ttcatttatc ttatttttaa ttaaactaaa
     9121 atataaataa aattactatt atttttagtt aaaacctttt gcttgatgta aaattttcat
     9181 atgttatttt agttaacact atcattaata taattgagat tactatagaa aaaactatca
     9241 aaatacttgg tacattatac ttaaccattt gttggctcat cataatccaa tttggagtca
     9301 ctgacataaa ttttatagct ttatctggta taaaacctac actaaagtat ggaattgcca
     9361 ttatcaatcc acctagtata aatggaatta cagccgattt aaatatagat gaaagtgtta
     9421 agcctatttg tgcaaatata aaagaagcaa aaatagtagt caatataaca attatataca
     9481 tttgtattac tgtaagattt aaattactat ttccaaagta ccataagtta tgaatcgatt
     9541 catttaaatt tttaaaatca aaaaaactaa aacctctaat tcctactaac aatataaaag
     9601 aaatattaat aatagataaa attaatccat tagctactag ttttgataat actactgatt
     9661 tttttccctt tttagttgta tttattaaac ctgtcatatt agaatcatat tctttaatgt
     9721 aatttccaga agttattata aacattatca aacctattag aggtattgag ccttctatct
     9781 tgtaaaatat atctgcataa gtatctaaaa catcaaactt tctaatcaga aaaaatccaa
     9841 aaactattaa aaacagccaa attatccaaa cactctttga ttttaatatt tttatcattt
     9901 cagctttaac taaatacatc atttctacta cacctccctt gcatcttcta aatcaaaata
     9961 aaacatgtat acatcttcga attttgcttg aactggttgt atattatcct cgcttggaat
    10021 atcctctgaa acaatcctaa gtactattga atcaatatca ctttgaatac ttacaacctt
    10081 atatttagat tgtatatcat caacttcaca ttcattttta acttgaacat tatatacttt
    10141 attttccatg tgacttaata tgtctttgtg tgttcctttc attaggagtt tgccatcttt
    10201 aatcattatt gtttcctttg caactgattc tatatcggaa attatatgag tagaaagtat
    10261 tattatctta tctctagaca tttttgctat taaattccta aatctagctc tttcttgtgg
    10321 gtcaagacct gctgttggct catcaaggac tattatctta gggtcgttta gtaaaacttg
    10381 tgctatccca actctcctct tcatacctcc tgaaaatttt cctatagact tatttctcac
    10441 atcataaaga cctactaaat ctaataattc tcctatctta ctatttaaat attttcccct
    10501 taaacctttt aaagctccaa tatactgtaa aaattctttt gctgtaaaat ttttataaac
    10561 tccaaattct tgtggcaaat atcctaaaat atttctataa tcagcatcca ttttaaatat
    10621 atcctcacca ttataaagta tctgaccttc atcaggtttt atcaacgttg ttatttgttt
    10681 cattaatgta gattttcctg ctccatttgg tcctagaaga ccataaactc cattttctag
    10741 agttactgta atcttgtcgt ttgctacttt tttaccatat atctttgaaa gattttctat
    10801 ttctaattta ttcatcttaa ctcccctttt atctacttat ataatctgat tttattacta
    10861 aaaaacataa tgacatagca cctatcaata ttgccatcaa aagtcctatt gctatattga
    10921 caatgtctat attcacttta aatatcataa tatcacctag ataatttcct attattttat
    10981 taaaaccaaa tatcaaatca taataattta catttgatac aactgaaagt aattttttag
    11041 gtaatatatg gattaccgac attatcttag ttatagatat aataaatata aaaaaactta
    11101 ttgaagatat tgaagactta cttataaaag acccaaatat ggctatcatg gcccatcctt
    11161 caaacatcaa aagctctatg cctatattta atattacata ctttgttata cttaaattag
    11221 ttttcaatgc aactacattg tctactattc taaaagattc taagtctcca ttaacaggta
    11281 ctccttgttg catacaagtt ataataaata ttcccattaa ataaacagaa taaattacta
    11341 atggaactaa taaagcaaca aatattttag actttaatgc ttttttcttc tcttttgatg
    11401 atagtatgat atcttttacc gaagtaacga cttcatctac gtaaatattg gatataatta
    11461 tagatataat gattaacatt cctacattta taagtgaatt tgtaactcta tagttaaata
    11521 ctttccaaaa actaatatcc ttatattcat tcacacttag attatcaagt tttttctttg
    11581 acattaattc aattttttta gaaaattcac ctgtatctgt ttgatttgaa aactgcttta
    11641 aaacattaat cttattttga aatttctcat tacctacgtc gataccactt ctcgtatctt
    11701 ctatacgtcc tttttcttta tctatataat aactttctgt ttctaaaaca ggcgcaataa
    11761 agatactaat cattagtatt aacactaata tccctagaga tataaacata ctcttagatt
    11821 tagccaattt ttttatttcc caatttacca atatatttct cctcctaaat cattttaatt
    11881 acacatatat attaaaactt aaatcttata taaatataat actaacctta aataaagctt
    11941 aaattatttt ataatttata ggtgtgttta ttattggagt tacatttatt atttttctgg
    12001 gaaattatac attttcaatt atttttatta tttttgatat ttttattgat tggaaatttt
    12061 attgttgttc aaattgtagt tattctttaa atttaaagat ggagtttttt aagaatagaa
    12121 cctactgtcc ttattatgga aagattatta aatagttgca tataacttta tttatcttga
    12181 atcttatttt taaaaacaat tataatttta gaatattttc tattctcaaa caagcatgtt
    12241 gaataatgga gcatcttcta gtattatata cttgtagaat aaaactaaat tggtaaaact
    12301 gggaatattt aaccttaagg agttaagtta tagaaactag tactaaaaaa ttttataaat
    12361 tatgttaatt gactaataga atgcgacttt ttatttttac taaatttttt agggggatgg
    12421 ataatatgtt tattggagaa atagacaaat gtacacatat actaactgct tacatcagta
    12481 gttcatatga ttattgtaat tttttagata cacagttaga tgattttata tcagaatatg
    12541 gagaaacggt agttgaaacc tgcttacatc aagtcttatt attagtaagt agatacaatt
    12601 aaaactaaat ttttctagaa aaaccttttt agatttatct actctaataa atatataatt
    12661 ttttgtactt tataagtaac tataacttct gctaaagtaa agatgtattg ggagtacatc
    12721 tttactttcc cattatagaa gttaaaagca tacaccataa aatcaatcat ccaatacaaa
    12781 ttatatattt cctatgtcta acttaattta caagaatcat tctatatgca tattctgcaa
    12841 tccactaaac atggctctaa acctttacta ttttatacat tctctataaa tcatacaaat
    12901 catatataaa atccccctaa tatgtttaaa ccacctataa aataacacca atatttagaa
    12961 tattcaatat caactgcata actggtcaat aaaaacgtat aactagacaa atttcaatat
    13021 ttatataaat aatacaagaa aaacaagcat tttatttata taagtttttt attttttgtt
    13081 tatattaaaa aactatattg attaatttat tttatttagt aattataaaa attcgtctta
    13141 gaatatattc tatatttgta gattagcttt aatattttta atttcacaaa aattaaactc
    13201 ccaatatttt tatccacttt tatctcatta attaattata ttatttttat gctttttaca
    13261 atttttccta tttaaatata tattaatata atcctctttc ataaaataaa tgttactctt
    13321 attaattaaa aaaattataa ccacttttga ttgctaatca aaagaaaata tctaagtaaa
    13381 ataaaaatta tatttgttaa gctttatgta ttatagtatt ttattcttac ttaatcatca
    13441 tactatagca aaatactaac ctaaaagtta gtattttact taaaaataag tgcttattca
    13501 aacatcaaat agaatatata ctattataaa taaatctata aaggaatgac ttttataaaa
    13561 aaatagtgaa aatgtaagat agagatgata aaaactacat tccataaaaa tttaacaaat
    13621 gaatatggat gtgaaagtat tagaaaatac cctatgtata aagtaagaaa ggtatttttt
    13681 gagattttgc aagaaaattt aactttattt attttctcga ataatacggc atggatttcc
    13741 gtatgcaatc atattacttg gaatatcttt tgtaacaata cttcctgcac ctataactac
    13801 attatctcca atagtaacac ctggcatgat aatagcaccc ccgccaatcc aaacattatc
    13861 tccaatagta actggagctg tttgagtttt acaaaattca aatgaaccat cttctttggc
    13921 attaccaaat ctatcaccag cattagttgg atgaaatgca gtatatattt gtacgtttgg
    13981 tgcgattagt gcattatccc caatgataat tttattatca tctaaaaacg tacaattcat
    14041 attgacttca caattatttc caaaataaat attatttcca taatctacat aatatggtgc
    14101 agtaatccat aagtttttac ccttaccacc aagtaactca tttaatattt tttctttttt
    14161 ttccaaatcc gaggaatctg tttggttata atctcttact aggtcttttg ctttatgcca
    14221 ttgagttaac aactcaatat caccacaatc gtaaagttct cctgccaaca ttttttctcg
    14281 ctctgtcatg tttttaatcc tccaaattta tattgttttt catatatatt ctagcataag
    14341 atttattaat ttatatattt tacttatata aaatttaata aataacaaga tttattaaat
    14401 atacagttga caatctatct ctctgtcatc ttaaaactct tttaactgta ataatctcag
    14461 agcaattttt tcacttttat tccttgttta tagctgataa gcacaatttt tataagaata
    14521 accttaattt aacaacctta tttatgttaa aaagagatat tattgatttt aataatatct
    14581 cttttactgg ataatacaat tatagaatat ttaaaataaa taatctgaca cttgactaat
    14641 aaatccattt ttcttccaat aaattgcact ctctataagg tatggattat ctgtaataat
    14701 actatctaca tttaggtcaa gcattttctc aattaaactg tcactattaa cagtccaaac
    14761 gaagattttt ttgttcattt tatgaatctt ttctactact gttttattaa caaaagttga
    14821 ttcaattcca tatatatcaa cataatttaa ctttgaaaaa tcaccatatg caattgccat
    14881 aaaatagcat gtcagtaaat tctcatccag tttttttact ttttgtaata tagttttatc
    14941 catagatgca actatacatt gattttcaaa attattttct ttaattaact gaacaacttt
    15001 ttttactacg tctccctttt catgtccatt aagttttatt tctattaata atttcacctt
    15061 acctttagaa tattttatct tttctttgag tgttggtatc ttttccccaa caaacttttc
    15121 atcataataa ccttttccat aataataaaa gcttcccgca tcatatgtct ttacttcatt
    15181 ataatttaca tcccaaacat ttttatctac tcctgtagtt ctcttaaagt ttgaatcatg
    15241 aagtacaata agttctccat ctttagtttc ttgaacatct atttctgcat aatcagcttt
    15301 agcatgtgaa gcttcttcta ttgctgccaa agtattctct ggagccattt cagctcctgc
    15361 tctatgagca attgctgttg tataaaatga aaatgatgta ttaaacatac catttatatg
    15421 tgaagaaaat gcaactgact ctatataaga aattaataat attaatacta aattaaaaac
    15481 aatttttgat atagattttt tctctttttt aatattattt ttagaaatac ttactccttt
    15541 atattgataa taagttgctg agataaatcc aatgtccaat ataaaaatga atattgacaa
    15601 aatcaatcta aaatattctt caaatgcaat acatctattt ataaatacat tcttcaaaaa
    15661 ttccatatca gtacaatatt tagtccatat gcctataaat ataattccac tatgataaat
    15721 cgcatatcca ataatagcta ctactaaaga taatattaat gaataaataa ttgttcttat
    15781 aatctttccc tttataagat taacactttc ttttcttgct cttttaaaat tttctgtatt
    15841 taaagttatc tcatgaatgc taaaaatcca tctaataacc gaaatatata ttattaaaag
    15901 aaaaatcata tagattatat ttaaaattat atcagacttt atataatcta gtatgtactc
    15961 tggtatttgt atttttccta taaaccctga aattaaaact gtatttacta atggaattat
    16021 taatatcaca aatataaata atagtatatt tttaggatat aacaatttta tagagttctc
    16081 aaatgatatt ttaaagagtt caaataaccc tattttttca tattttatcg atttattaaa
    16141 acaaataatt acagaggtaa attcaaaaaa tgcataaaaa gctagtatta taactgatag
    16201 tattatcaga actattgaca tgggattggt caaaactttt ataaaattat ccatatttag
    16261 gtagactata tgtaaacttt ttattaaaat atcaaatata tatctaatag atggccatat
    16321 aaaaaataag gctaatcctt tatgaaataa ttcaaataaa attaatgtac taaaattata
    16381 ttttattata aaaacaagtt tacttaaaat atttttaccc gtaaatataa aatttcttaa
    16441 aattctcttt tgcatgttta tctccttgta tctgtttgtt ctaattttat catatgtttt
    16501 aaatacattt agaacattaa tatgtattat tccaagttat gatgtataaa tgcaaaacaa
    16561 atactctttt ttattgcata gctaatcatc aatatctata tagcttaata cttataagta
    16621 ggatactcca tatttacaaa ataaaaaagt atctccttta taactttcaa aaatcacatt
    16681 gagatacttt ttataattta aatctatata cttaatttaa aaaacattgc ataactattg
    16741 tgctattatt acaattcttc atataaatca gtacttaaat attttaaacc actatcatta
    16801 agagttaaaa ctatattttt tcctttttca ctgctcttta acaacttaat tgctgcacat
    16861 acatttgccc ctgaagaaaa tcctgcaaat acaccttcta atttagctaa ttttcttgct
    16921 acatcagttg cctcttcgtc tgtaacttga atataaccat caataagttt cttgtctact
    16981 aatggcaaat ccatagaata tcctccacct tgtattttat gcccttggtc agttatttct
    17041 ttacctgaat aaattgctgc tgtttcaggt tcaacaacat aacatttgat agaagaatta
    17101 tgttttttaa gtgtttttga acatcctgca aaagtactac cacttccaag aaaatctaca
    17161 aatacatcaa tatttccatc caattgttcc cacatttctt ctgctgtata cttttcatgt
    17221 gcatgattac aagcttctaa attaaattgg tctgctctaa atgcatttct ttcttttgct
    17281 attttttgag cctcaatttc tacaagtgcc aaatcttcac cagatacctg tccatgaact
    17341 gaattaggca tttggtctac aagaactact tcagcaccta aagctttcat cattcttgct
    17401 ctttccatag aatttccttt tgacatacac gctataaatt tatatccttt acatgcacaa
    17461 gctattgcta gtcctgttcc agtattacca cttgttaatt ccacaactgc ttgacctgga
    17521 actaataaac ctgcattttc tgcttcggta atcatttgta atgctacacg gtccttttta
    17581 ctaaatcccg gatttaagta ttccatcttt gcataaatat taccttgaac tccaaattca
    17641 tctgctattt tggataaatg taacatatga gtattgccta tagcctctgt aacattatta
    17701 agtacacgca ttacaattcc cccttaatct ctcaactatc atccgttgaa aaacaactct
    17761 ttatgcagta taatttatat tacggatgta cagtgtattt aacgttcatt atattataca
    17821 tttgtaaatt ataaataatg ttaaataaat tatacattcg taaattatat ttgtcaataa
    17881 tttacatttt aaggagctac tatgagtatt aatactgtta ttgctaaaaa tttaaataga
    17941 ttacgtaatg aacgtaactt aagtctaggt caacttgctg aattatctgg cgtaagtaaa
    18001 gtaatgcttt cgcaaattga aaagggagac tcaaacccaa cagtaaacac aatttggaaa
    18061 attgcaagtg gactaaatgt tccatatact gcaatactgg aacaacctca aaatgaaact
    18121 tttattgtat caaaaactga tatagatgta caagtttcag aaaataaaga ttatcgtctt
    18181 tattgttatt atcccaatac accaactaga aacttcgaat tatttcaaat ggaattagaa
    18241 gaaggtcata gttatacatc tgttggtcat tctgaaaaat cacaggaata tattatgatt
    18301 atagaaggtc aattaaaatt agaagtaaat gactctattt atcaacttag agaaaatgac
    18361 tctatttgtt tttcagctga atcaattcat acataccata atcaaggaga aaaaacattg
    18421 aaagcagtaa taataaatta ttatccagtt tagccatgcc atttaataat agaataatta
    18481 ttttctatac aaaaagataa atcctttgat taggatttat cttttttatt ttatttttct
    18541 ttataaattc attatatatc tttacacttt tatcaattat gttataataa gcttatataa
    18601 aagttttata tttttgacaa atggagtaca aaatactcct ttttcttttt tactattgtg
    18661 ataattattt agttagtatt aaaatattat cacttaaaac aaatacaaaa cgtctcttat
    18721 atgtacattt ttcattgttg taataatgat ttgtgtatgt atttctcaca attggagtgc
    18781 ttatgcactc tttttaaata cctttattac cataacctaa aagctatttt attatccctt
    18841 ttagtttatt tttaagtagt taaataaatt attttatatt tttttcttca tttatatgaa
    18901 acttttgttt taccactata tgcactttat atttactaca aataacacat aagcttactt
    18961 ttatcataag actcctatat ctaaatataa tttaagaagt taaataattg aatagtatat
    19021 taaaacataa tggtaatgac aaaaatataa aaatctttat agtcataaat tttatcttat
    19081 catttttatc ctctccatta aaataattat cttgataaaa tgtagctcta ttttgataac
    19141 ctgtttttaa aactccattt tgaattaaca gcagtataaa aaagattgct aataaaataa
    19201 agttataatt tttttctttt aatctaaaat tagctataat aacaatgaaa ctatataaag
    19261 catataaaaa ttttttcata aaaaacacct aaattctata tttgtatttt atattgagcc
    19321 aaatctaatt tctgtatatt tattaagtgt agttctagtt cctattgtaa tagcattaaa
    19381 tattttttaa tttttatttt caaagggcat ctccttatat ttaaattata gtatgaatat
    19441 tcataaattt caatctattt ataaggtaat tattttttat atctaatatc ttgtcattaa
    19501 gttttattat atatatttat aaatttttca atacttttta taattattct acttttatat
    19561 tttaatcatt aaaactaaag tcaatattat gtggtaatta tttactacaa atgataaaaa
    19621 ataattatat tttaaaggag aaaatgctgt ataaattatt ggggtatttt acctatactt
    19681 gttgcaaatt tacataccac ttagttaata taaaacaaat ttcaaagcga ttggacaacg
    19741 aataaaaatt gcaatttata taccatatag ttaatataaa gcatatttgt gtcgatatat
    19801 agttctaact aagtataaga tttacatacc tcatagttaa tataaaacac atattttaca
    19861 tgtttgaaga ttttatcaga aaccctattt acataccact tagttaatat aaaaccagaa
    19921 ctaataggaa aagaaggtta tacgccagag atatttacat accacttagt taatataaaa
    19981 cttgatatat ttttttatgg tacatatttt aaagtaaatt tacataccac ttagttaata
    20041 taaaactatg agtaaagtat ttacagactc taaagactat gaaatttaca taccacttag
    20101 ttaatataaa acgatgaata tcataagatg ttatgtaatt cattatatga tttacatacc
    20161 acttagttaa tataaaaccg gcaacagatt taataaatat atgtgacctt ttagaattta
    20221 cataccactt agttaatata aaactcagct agattattta aatgatgcag tcaaagaatt
    20281 atttacatac cacttagtta atataaaact aggtcttata tttattacta ataaattaaa
    20341 accttaattt acataccact tagttaatat aaaacttttt atccaatcaa gatgtaggtt
    20401 caacagtaaa taatttacat accacttagt taatataaaa cttactaatc tctttttctg
    20461 ttaatgcttt caaagtaata tttacatacc acttagttaa tataaaacaa aaatagtgct
    20521 aagtcaagat atataataat aataaattta cataccactt agttaatata aaacttttac
    20581 cttttcagag ttttatttgt attgttgtga tttacatacc acttagttaa tataaaactc
    20641 ttttaaaatt actgtctgtc tccctactga acttgtattt acataccact tagttaatat
    20701 aaaacttata ttttatataa aagagtgtca tatctttaat atatttacat accacttagt
    20761 taatataaaa ctctatcaac caatgctaca ccatagggaa ttaggaaaat ttacatacca
    20821 cttagttaat ataaaacttg ctaggcaatc catttttaga aagtactaaa ttctatttac
    20881 ataccactta gttaatataa aaccccaaaa taaactaagt attttcagta cttacacaca
    20941 tacaactctc tcaaatttgc agtgaaccat gagtagtgca attgataaca tttatcatac
    21001 accctcaatc ccttacattg caactgttaa accctacttt atcaaaaata tcgctcactg
    21061 caaaatttat atatttttat tatatcataa aattcaaact ataaaattaa aatggaataa
    21121 tttatcaatt taagaacacc tacatatttg taaatactta ctatattatc tattctaata
    21181 gttcttcttc tagctagaac taatataaaa atcatctctg aaagattagg acatactaat
    21241 ataaaaataa ctataaatag atattctcat attttaaacg atatggataa aaaagcttct
    21301 gaaaatataa tcaaagttct ctttaaataa cattccattt tatgtaagta ggcattatat
    21361 ttttcttaaa tgtcacttaa atgtcagtta tatataataa tagtaaacaa ctgtatttca
    21421 ctaatatttg ctattatcta atagtattta tagtttagat ttgatataat acatgtggta
    21481 aaattttgat ttgtaaaaca aaattttacc tacatatatt aaaacaaatt taaaactaag
    21541 gagacctata tgttaaaagt attaaaagga aatataattt ttacaaaaac ttcagaaact
    21601 ttcacagtat ttgaaaatag ttatattata ctggaaaaag gtaaagtaaa gggaatattt
    21661 aaagagatac ctaaggaata caaaaaccta aaagtagtag attacactga taagcttata
    21721 atacctggta tgaatgacct ccatgcccat gcctctcaat ttaaaaatct tggaatggct
    21781 atggataaag agcttttgcc atggcttgaa acttatacat ttccagaaga atcaaattat
    21841 aaagatatag aatatgcaac aaaaatgtat aaaaaatttg taaaagaact ttggaaatct
    21901 ggaactacaa gaatagcagt gtttgcaaca gtacataaag aagcctctat gaaacttatg
    21961 gatatattca aagaagttgg tcttggagca tacgttggta aagtaaatat gaatatgaat
    22021 tgccctgata ctttattaga aaacactcag gattctatta ctgatacaga agaaattata
    22081 aataagtata gtgatacaga ttctattgta aaaccaataa taacacctag atttatacca
    22141 agctgtacaa gtgaactttt aaaaggttta ggagatttat gtttaaaata taatattcct
    22201 attcaatcac acttatctga aaattatgat gagattgaat gggttagaag tctagaacct
    22261 gaatctaaat tctatggaga tgcatataat agatataatt tatttggtca aactcctact
    22321 ttaatggctc attgtgttca ttgttctcag gatgaaatag atttaatgag agaaaataat
    22381 gttatggcag ttcactgtcc agcttctaac tttaatgttg gtagtggtgc tatgcctatc
    22441 agaaaattaa tcgataataa tattagatta gcacttggat cagatataag tggtggacat
    22501 acattgtcaa tatttaaagc aatggtatct gcaatacaat tatctaaatt atattgggtt
    22561 aactctggta agaagtataa tttcttatct ttatctgaga ctttttatat tgcaaccaaa
    22621 agtggtggaa gtttctttgg aaaagttggt agctttgaag aaggttatga ttttgatgca
    22681 ttgattattg atgattcaaa tttaaatcat gacaattatt ctatacttga aagacttgaa
    22741 agatttatct atgttggtga tgatagaaat atcattcata gatatgtatg tggaaaacta
    22801 attgaagaac ctaatatata attataataa aaattttaat tatatattat ggttaattta
    22861 tacaactata attaataaaa gagtatattt taaatctaaa agctataggt tgaaacatac
    22921 tctttttatt ttgtttattt atagctttag ttattaatca tatataaatc tacaaaacgt
    22981 attcttagta acttatattt tttgatatct acaatcataa gactatatta ttattggatt
    23041 cagacctcaa aaatattgcc ttttgaacat tattatattc aaagctatgt taatttacaa
    23101 tgatatatct aacatgtact gtaattatca aacacttcta atctcctata ttttcatatt
    23161 aatgtaatat cttttttatt aatactaaaa tttttaatat ttataatata taactcttca
    23221 acttattctt ttcttgctta ctttgcaatt tattttatat tttttatcaa tttaagcaat
    23281 tccatctctt ttttattctt attaattttt ttaataaata ctaaattttt ttgtaaatat
    23341 atagcatttt ttacattatt tttatataat atatatgtac aaataatttt ggaggtttta
    23401 tctaatgagt gaatttaaga atgttactgc agtaaagaag gcaaacgttt attttgatgg
    23461 taaggtaagt agcagagtaa taatactgcc taatggagaa agaaaaactt taggattaat
    23521 gttgccagga gaatacactt tttctactag agaagaagaa ataatggaga tgcttgctgg
    23581 aagtatggat gtaaaactgc ctggaagcaa tgagtttgta acttacaaag aaggacaaaa
    23641 atttaatgtt cctagtgatt caagttttga cttaaaggtt aatgaagttg ttgactactg
    23701 ttgctcatat atagctgatt aataaaaata catattctta cataaaatta aacacatcta
    23761 aaaagagcag ttcaactaaa actgctctta tttatatcat tttaaaatta atttaaatct
    23821 ggaacaattg tctctaatat ctcatctaag acaaataaca taacttttat cataattggc
    23881 attaatattg ctaatgccat agttatgaga attaattctc tactcaatgc tacaaatgag
    23941 aataatccac ctaaaaatag aatcccaata acaaatgcaa tagtcatact tactattaaa
    24001 aataatcttt ctttattaaa tggcaaacat tgttgtctta atattaaaag accacataca
    24061 ccagttaata tagcacacat tgtggaaaat acacttgaac tataacccaa atattcaact
    24121 atattgtaaa caataattac atttactgtc acacatagtg ctcctggtaa agcatttttt
    24181 aatatattga gtaaaaaatt tcctgaaatt ctacttttgt ttgcttcaag agctaagaag
    24241 aatgatggta tacccactgt tacagcccca atgagtgata attgtatagg aacaaatgga
    24301 tactgtctac tgaagaagaa taatgttaat aacgacaaga agaatgaaaa aattgtcttt
    24361 actaaaaaca aagaagatgc tctttgaatg ttattaatta cttttcttcc ctccataaca
    24421 acctttggca ttgatgcaaa gtttgaatct aataagacta aattagacac attcttagta
    24481 acatcacttc cagatgccat ggcaatgcta caatccgctt ctttaagtgc tagcacatca
    24541 tttacaccat ctccagtcat agctactgta tgattttgtt tttttaatgc taaaatcatt
    24601 tgttttttct gttgtgggct tacccttcca aaaacactgt atttatcaac tgctttgtat
    24661 atatcactat catttttaag tgttgttgca tcaataaaat tactagctgt tttaagacct
    24721 gcttttctag ctacctcact tactgttata ggattgtcac cagatataat ttttatatct
    24781 acaccttcat tgtaaaaaaa ttctaaagtt tccttagctt catctctaat tttatccaat
    24841 atcaatataa aagctagtgg ctttatatct tcaggaatat tatcatcttc catataagaa
    24901 tcactatgag ctaaaactat tactctgttt ccttttttag aatatctttc aacttctatc
    24961 ctaagttttt tatttttttc cttaaatata aactcaaatg cacctaataa atatgtacct
    25021 ttattttcaa aggtaacccc actgtatttt ctttctgaag aaaatggtat taaattctta
    25081 gctttatacg tatctaaaac attatactta tctcttattg catttagtgt tgcattatca
    25141 tctttgagag aattacatat attccccatt atttcattaa tatccacttc ttccaacatt
    25201 actatatcat caacttgcat tttaccttct gtaattgtac ctgtcttatc aagacatagt
    25261 gtatcaactc tagcaagagt ctctacacag tacagttctt gcactaaagt tttatgacta
    25321 gcaagtttta tagttcctac agctagagca atgctcgtaa gtaatgttaa tccctctggt
    25381 atcataccat ttacagctgc cactgtacct actacagatg tagctataga atctccattt
    25441 ccaaaatgtt gttttgcaaa caatataatt cctagaggaa ttattattat acctacaatt
    25501 tttaatattg catttaatga atttctaagt tgagaattat gttttttaga aatctttgca
    25561 tcattagcta tcttatttgc atagttatct tttcctatat tttcaactct tacaaaagct
    25621 tctccagaaa ctacaaaact tccagaatat aaaaaatcgc ctttattttt tataataata
    25681 tcagattcac ctgtaaccaa ggactcattt acctctaatt ttccatttaa aacttttgaa
    25741 tctgcacaaa tttgattacc tgtttttaaa atcataatat catctaatac taattcttgt
    25801 acatcaatct cttttttctc tttttctctt atgacagata ccttatttga aactataaca
    25861 gatagattgt ccaataatct tttagctctt atctcttgta ttactcctat aatagtatta
    25921 attacagcaa taaatataaa taaggtattt ttaaaagaac caactgaaac taataaacag
    25981 actaaaacaa tatttatgag attaaaaagt gtaaatatat tgtctttaaa aatttgttta
    26041 tatgttttgg tttttccatt atcaaatgca ttaattaaat tatcatctat tctactttga
    26101 agttgatttt tatttaaacc aacatttata tcacaactat acctttctaa attaacctta
    26161 tccatatttt actcctttca acttagcact tttttatact caaatctaca aatatattat
    26221 aaaattctca atttttttat tttattattc tatagtttat ataataaaat ataaatctaa
    26281 agatttaaat attataattc ttaagatttc ctaaattttt atgaatttcg ctatatttta
    26341 gttaagtttt tcttaatata aaagagtaaa taaagttaag gcaagataaa ttcaacaatt
    26401 cttat
//
LOCUS       DAEQCW010000047        26393 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.047, whole genome shotgun sequence.
ACCESSION   DAEQCW010000047 DAEQCW010000000
VERSION     DAEQCW010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26393)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26393)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26393
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.047"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            217..1092
                     /locus_tag="KRO40_001995"
     CDS             217..1092
                     /locus_tag="KRO40_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA glycosylase"
                     /protein_id="HBH2092815.1"
                     /translation="MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVA
                     KGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGTDYTEIKNKLKNMDEYLNKATEF
                     GWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
                     EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGV
                     GPKVCDCIALFGMQKYDSFPVDVWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFA
                     QQYLFYYARELGIGK"
     gene            1110..2600
                     /gene="cls"
                     /locus_tag="KRO40_001996"
     CDS             1110..2600
                     /gene="cls"
                     /locus_tag="KRO40_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBH2092816.1"
                     /translation="MGVIGTIFLFYLIISYLAGAIISVIILLENRDPAKTMSWLLMFI
                     IFPGVGLMIYAISGRNIRKRKLFKTQKLANNIKEKKLFDTLEKITEIVELEKESIKQN
                     KLLRDEEDGSYRKRVINMLLKTGMFPFTKNNKVDVFVDGNEKFKRLIEDIREAKDHIH
                     LEYFIIKDSEIGRVLKEELIKKAKEGIKIRILYDDVGCWRFWFNRKFFREMREVGIEI
                     AAFLPTKFPIIGGKLNYRNHRKIVVIDGIIGYTGGINIGDEYLGKNDKFGYWRDTHIR
                     IKGISVYMLQMTFLIDWYYTTKEVLVTKNYFPSVGNVGESMIQVVASGPDSDWEDIHY
                     AYFSAICQARKNVYIETPYFIPDESLLKAIKSAALSGVDVRIIFPKIADHKIVNIASY
                     SYFEEILRAGGKVYLYNKGFIHSKVVIIDDKIASAGTANMDLRSFMLNFEVNAFIYDE
                     EVIRVMTDDFFEDLSYCEELNLEVFKNRNIIQKIKESVARLFSPIL"
     gene            2793..3077
                     /locus_tag="KRO40_001997"
     CDS             2793..3077
                     /locus_tag="KRO40_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012062101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HBH2092817.1"
                     /translation="MKIRPLADRVVIKKVEAEEKTASGIVLPGAAKEQPQIAEVVEVG
                     PGGIVEGKEIKMELTVGDKVIFQKYSGTEVKIEGQEYTILRQSDVLAVIE"
     gene            3110..4738
                     /gene="groL"
                     /locus_tag="KRO40_001998"
     CDS             3110..4738
                     /gene="groL"
                     /locus_tag="KRO40_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729227.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HBH2092818.1"
                     /translation="MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFG
                     SPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREG
                     LKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLI
                     AEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYI
                     LITDKKISNIQELLPVLEQIVQQGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKA
                     PGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSVKVTKESTTIVDGS
                     GDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKL
                     RIEDALNATRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPL
                     RQIAINAGLEGAVIVQNVVNSEAETGFDALNEKYVNMIEAGIVDPTKVSRSALQNAAS
                     IASTFLTTEAAVADLPEKEDAGMPGMGGGMPGMM"
     gene            5000..5740
                     /gene="larB"
                     /locus_tag="KRO40_001999"
     CDS             5000..5740
                     /gene="larB"
                     /locus_tag="KRO40_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarB"
                     /protein_id="HBH2092819.1"
                     /translation="MDLRKLLEEVKNENIDIDFALEKLKDLPYEDLGYANIDHHRELR
                     NGYPEVIYCEGKSDEHILGIIDKMNQKSSNILGTRCRKETFLKIKEIYNHAEYEEASK
                     ILKIQNHDIENIGKGKIVIATGGTSDIPVADEAYHTAKFLGNDVDRIYDVGVAGIHRL
                     LNKRHKIDSARVIVAVAGMEGALASVIGGLVDVPVIAVPTSVGYGANFGGLAALLAML
                     NSCASGISVVNIDNGFGAGYLASMINKL"
     gene            5824..6558
                     /gene="larC"
                     /locus_tag="KRO40_002000"
     CDS             5824..6558
                     /gene="larC"
                     /locus_tag="KRO40_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarC"
                     /protein_id="HBH2092820.1"
                     /translation="MSEKILYFDIISGISGDMTLASLLNLGVPKEIFLEEIHKLRMSD
                     EFNINISSKTENGIVGTKVEVITKEKHTHRNLVDIFEVIDKSTLNENVKSKAKKIFMV
                     IGEAEAKVHGTTIDKIHFHEVGAIDSIVDIVGASILVDLLCVDKVCASTVSVGSGFVK
                     CEHGIIPIPAPATIEILKGVPIKLNNVNGECTTPTGAAIIKVLCDEFVDELEFSPKQI
                     GYGIGHKKFEVPNILRTVLGEKKKKN"
     gene            6588..7007
                     /locus_tag="KRO40_002001"
     CDS             6588..7007
                     /locus_tag="KRO40_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF111 family protein"
                     /protein_id="HBH2092821.1"
                     /translation="MSSEIYSYLYEKILDEKALDIYTESIYMKKNRPATKLSILCNES
                     DLEKFIKILLLETSTFGVRYNAYNREILERKFVKLDTKYGVVTVKLGYYKGKLVKATP
                     EYNECKTIAKNEDIPIKKVFADINFRIKEEFSENLLT"
     regulatory      7067..7168
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            7389..8924
                     /gene="guaA"
                     /locus_tag="KRO40_002002"
     CDS             7389..8924
                     /gene="guaA"
                     /locus_tag="KRO40_002002"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HBH2092822.1"
                     /translation="MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKE
                     KNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILGICYGIQIMSHVLGGVVRKGNKQ
                     EKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
                     RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKA
                     LCALSGGVDSSVAAVLIHKAIGDNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRV
                     NAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFLVQGTIYPDVIESGH
                     GNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGP
                     GLGIRVIGDVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDER
                     TYAYLVGLRAVTSSDGMTSDWYKMPYDVLERISNRIINEVDGVNRVVYDITSKPPGTI
                     EWE"
     gene            9463..10893
                     /locus_tag="KRO40_002003"
     CDS             9463..10893
                     /locus_tag="KRO40_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2092823.1"
                     /translation="MILNQIFIEAGGIMRNKIIIGITFSLVLLMSGCASKQTAEINVL
                     ATTDLHGVIPYELTSYVKEERKKDKNLTLVDAGDFFDSGEVFGSSMDSYFSARYKDID
                     NNTERYIETPISKDMKEVGYDVAVLGNHEFISNNKFYLDNMISDFEKQKINILSANTY
                     KKNGDSYTKPYIIKNINTPEGNVKLGILGLTIKEVGERKQWKDGKLVDSKSLELKDQE
                     GYNGELYMNDLVEDAKKWVSIMEKEKPDIIVAVAHTGEKPKKPRNPGNRIQDLAQQVD
                     GIDAIVAGHNHVQIEQHDYKNKSGENVIVTEPGKHGECISKINFKLEKNNDKWNIVDK
                     SSKLIKFEKNQESDKFGEFISSINKVSKDKKEIRLSEVKTPEWDKIYVFKSGTSADDI
                     YKTIGYKWRNISSPKGDDMVQIVVMNNNKPVSYVYGEAEVMPINIKCDESEYKDNVVT
                     IYPNKNDKFKIEKGKQEYSINLKHIQ"
     gene            complement(11041..11391)
                     /locus_tag="KRO40_002004"
                     /pseudo
     CDS             complement(11041..11391)
                     /locus_tag="KRO40_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904812.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
     gene            11386..11907
                     /locus_tag="KRO40_002005"
     CDS             11386..11907
                     /locus_tag="KRO40_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBH2092824.1"
                     /translation="MFSIGGGYAIIPLIQEKVVNQTGWISEKMFTDIITISQMTPGPL
                     AVNTSTFVGLQIGGFWGAFAATLGCVLCGVVIALFLYNFFQKHQNSTYIFEILNGLKS
                     ASLGLIISAAATIIILALFGTNKVYFNSIFEMLNWTALIIFFVTLLIVRKWKINPIVI
                     IIISGILGIFFYL"
     gene            complement(12036..12830)
                     /locus_tag="KRO40_002006"
     CDS             complement(12036..12830)
                     /locus_tag="KRO40_002006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2092825.1"
                     /translation="MIFCNSFITRKSSMNIVVTHTPIVTTLEMQKAYEPLAKHNVNIF
                     AFDFSGTGKSDGYEKDFSRNSIVKDLDSVITYIEKNYSSNIHLYGNTGIGGMFAQYYA
                     CSDNKLKSFAQFACVDYKNTTGVGYTYLTVKLLNFFFKFLPNFHITVKPPKYKGYNEV
                     YDNEFYKIFEKKNPHIWKNSTKIINTMLECFIAEDSKIKDGVNIPTLVFKTLHDRYFK
                     TQYFDRYYNSLKCKKKLVEINNVHNSYYIDSEKFCQEAYDWFVENQ"
     gene            complement(13054..16482)
                     /gene="uvrA"
                     /locus_tag="KRO40_002007"
     CDS             complement(13054..16482)
                     /gene="uvrA"
                     /locus_tag="KRO40_002007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH2092826.1"
                     /translation="MKINNYKNQSIITNPKKFENKYQDLPKTPIELLKVVQSLVIHGD
                     QGKLYGISFNKQQSDEELLRTIPQMLKRIFEINSNPLTIPRNPKQRLVGMCRDYSLLL
                     VSLLRYRGFEARMRAGFANYFESELTYEDHWLVEYYDTLTKRWIRIDAQIDDIQKNYF
                     QINFDTHDVGKTDGFLTGSEAWIRCRQGHAHPDDFGYNKNWKGWHSVKGNLLHDFNNM
                     IGLELLPWDLWTELSSKKYNQLTRAEKNLLDEMAEILSSGNIKIEDLNLLIEKLPEDY
                     LKSIFSQLKILGISEIKELGNPLELEKKFKFTKSINKSIKNSLCHNKSSIYLKGGRQN
                     NLKDVEVTIPKNQITVITGVSGSGKSSLAFDTIYEEGKRRYFENLSNGAKLSEQLQKP
                     EFDLLQGLTPTIAIEQKKGSQNPRSTVGTLTSIWDYLRMLFVSIGKSYCPYCKIPLEK
                     KNNTKNYCPHCQTIFSKINTSTFNANSHTGACHDCNGLGFTYQVNPQLIVKDPTISIL
                     DGATYYFGKLRGKKPNGNWMVGELYAIAKDKNIDLDIPWNELPRDFIDAILYGTDDKI
                     YEFSFESKGRESKIRRPASGAINHIQRLFRESSSENNTLHQYMNKIPCNTCGGELLCI
                     EARFTTIKGYRFPELTKMTIEQLWNWLCELPNQLQKNELSLVNDILTELKIRVSYLLK
                     VGLSYISTDRTSPTLSGGELQRVRLSSQLGSELVGLTYILDEPSIGLHPRDHNLIIKM
                     IEELRDKGNTVIVVEHDKDTILSADYIIDVGPSAGTKGGFIIAEGTTQEIIKNPNSIT
                     GKYLSTYNKTGSQNKTIPSKWLSLKGCHANNLKNIDVEIPLNCMCSITGVSGSGKSSL
                     VFHSLLPALEEKLKQKSIPDKNYTEFTGFDAIDDFILMDQTPIGKSSRSTPATYINIF
                     DEIRSLFAETPQAKQKLLDESYFSFNSKKGQCPNCQGLGKTKIILQYMADQWVTCSEC
                     QGKRYQKEILSIQYKGKTIADILDMEVAEAKTFFSDCSDIYRKLSLLDEVGLGYLKLG
                     QNTLGLSGGESQRIKLAKELGTKTKKRMLYILDEPTTGLHFKDIENLLITFRKLVNEQ
                     HSLLIIEHNTEVIRASDWIIDIGPDSGINGGEIVASGTPDEIKINPNSITGHFI"
     gene            16801..19035
                     /locus_tag="KRO40_002008"
     CDS             16801..19035
                     /locus_tag="KRO40_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2092827.1"
                     /translation="MKLSRYKKNSLVLSIILCSLIISILVITVFNTVKLHNISNKQSK
                     NYLNDVSTQIVMNVDSKIKFILSDLRIMADFIKQYEGDSRYEYLSKRKTSYKYYDVGI
                     IDLEGKAEFLSGKKFDLKNTASYKKGIEGKEYSEVIESMGFVLYSVPIFNDNHEVSSI
                     LIGVSNKESMNEILNIDNFNGEGTIEIINSKGKPLFIGKNTELIKDLSHKYKDSTDEP
                     WAQKMLNDFKNDKSGNITITSSKGVQCLLTYHPITRGLNDWHFLLIVPEDAVLGELNK
                     LNSFTITMTFIITCIIGIITLILYIIRRKYVNQIENIAYLDSITNGINSTKFSMLVKP
                     LISESPDSTYMMIAMNIKDFKLINDCFSSEKGNMTLKHLYNILYKNIDENEEFVCRHD
                     ADLFYLLIKNRPVLEALELLYKIEADTNYFNKNRENPYFLRLSVGIYTIENHNEDLIT
                     IQDHANTARKSFNKTHQSDFSFYSDIERKRLISEKEISNLMEKALENKEFFMCLQPKI
                     DIKSGKISGAESLVRWKNSEKGIIYPSDFIPLFEKSGFICKLDLYILEETCKLISKWI
                     KEGKEVLRISVNVSRQHLNDKLFLEKYKHICNKYNVPTCLIDLELTESIFLENPEAID
                     IIEDIHSNGFKCSIDDFGFGYSSLGILKDFKVDIIKLDRSFFVSKNNIDRGKVVIKSI
                     IELSKRLGMKVTAEGIEELEQVEFLKNVGCDYIQGYVFSKPLLISDFENFAYENNKIK
                     NIHY"
     gene            19291..21321
                     /locus_tag="KRO40_002009"
     CDS             19291..21321
                     /locus_tag="KRO40_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092828.1"
                     /translation="MISGRMLLIMNFLKGKNKTSYKDISKQLSIEERKVRYDINNLNI
                     VLRSLNKSVIQKMNKGVLIIPDDFQVVCINNNEYVFSLTERVSIMKIISMFKIDNLNL
                     EKLSKEFQVSRSSIKNDLNVLSSELERNQITITYDKSFKISGEEDIIYKQRLNILKSY
                     SYLFGKEKSDLSVFEKYLVNVIEKIFKGIYLIDIYNWSMNLLLQMGWTLNDESFTWYV
                     SNIFLFTWYIHSDEKHPLESASLSEPCFENKFDQEFETIIQKKLTKEQIFLLKSFVFF
                     TNKYASLNEDMDLISTEIIVQDLIYNMSEILEISFKEDMILYKGLLNHIAPLIERIKQ
                     NIQIYEELLHVIPDKYQYVLEATKVSIQKNRVLSQIKNENETILLAIHFLGSIHRNER
                     NNYKNILLVCGFGYGVIAMLKDSLVNDYQINIVESIPSYKLQDYKEWESIDFIITTSK
                     IVIDLPKTIIEINPFLQEEDYLKFEEKGIKRKNVLTNYMSIKKRLDFLEEDAQKRVLS
                     IICQELGYSDERILFRQLNLSDLIGIDTIRIIDGDMKWEDAVKFSSNILANCDFVSAQ
                     YAENIIDILKNVGFYAVKDNEFALLHGNDSSLVKVSSISLLICKEAVSFGDKKVKIIF
                     CLASRDKKEQIPAIINLTKMVYKTNFIAMLESAKTKEEAEVLIHKYEKEVTV"
     gene            21318..21770
                     /locus_tag="KRO40_002010"
     CDS             21318..21770
                     /locus_tag="KRO40_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2092829.1"
                     /translation="MNKLVNVKCSFKIHVNSKEEAIISLVDVVSKEGYLIDKNQFLKD
                     VLKREETLSTYIGHGIGLPHSQSVGVKNSCITIGKLDTPIEWTEEGEKVDLIFLISVT
                     KDNENNLHLKILSKLARLLMHESFRNQIRCSDEQTVYNLIKEKIEEED"
     gene            21772..22827
                     /locus_tag="KRO40_002011"
     CDS             21772..22827
                     /locus_tag="KRO40_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit EIIC"
                     /protein_id="HBH2092830.1"
                     /translation="MRILKFLQKHLMTATSYMIPFVVAGGILFALSVTLSGQAAVPET
                     GWLAKLNQIGAAGLALFIPILGGYIAFSMADKPGLAPGMIGAYLAKEVNAGFIGGIIA
                     GFIAGFVVLQLKKIKLAPTMRTLGSIFIYPLIGTLITGGIIVFLIGEPIASFMTWMTN
                     WLNGMSGVSKIPLGGILGGMIASDMGGPINKVAATFAQTQVDTLPYLMGGVGVAICIP
                     PIGLGLATLLFPKKFSKEERDSGKASLLMGCVGITEGAIPFATSDPVRVIPCIMAGSI
                     IGNIMAFLLGCLNHAPWGGLIVLPVVDNRLGYIASVLTGAVVVAVLMKLVKKDVKEDE
                     EIEEDLDESIELIFEEL"
     gene            22894..23202
                     /locus_tag="KRO40_002012"
     CDS             22894..23202
                     /locus_tag="KRO40_002012"
                     /EC_number="2.7.1.202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose-like transporter subunit IIB"
                     /protein_id="HBH2092831.1"
                     /translation="MKIVAVTSCPSGVAHTYMSAESLELSAKKFGIEIKVETQGSSGI
                     DNELSLKDIDEATCVILTNDVEIRNMERFKGKKVVRMSVSEIIKKSDALIKKIKDTFQ
                     "
     gene            23306..24571
                     /locus_tag="KRO40_002013"
     CDS             23306..24571
                     /locus_tag="KRO40_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II D-tagatose-bisphosphate aldolase,
                     non-catalytic subunit"
                     /protein_id="HBH2092832.1"
                     /translation="MKKLPIKTVVQRLLNLQEEGKSATLLGIGPMSPNLLQASFELAK
                     DDDFPLMFIASRNQVDADELGGGYVNGWNQETFTKDIKKVADKVGFDGLYYLCRDHGG
                     PWQRDKERNDHLPVDEAMELGKKSYLADIEAGFDLLMIDPTKDPFEIGKVIPLDVVLE
                     RTVELIEYCENERKRLNLPDIGYEVGTEETNGGLTSTETYETFITRLKVELDNRGLPM
                     PTFIVGQTGTLTRKTEQVGIFNFRNAYDLAQMAKKYGVGLKEHNGDYLDDVTLLEHIP
                     SQIIATNVAPQYGTEETRAYLKLAEVECKLEKEGLVEKTSNIRHVLLVNAIECGRWRK
                     WVVGEQKNLTTEEIFKDEVLSNEILDIAGHYTFNNDDVKKEIEVLYDNLSKNNIDGQR
                     FVVDHIKRPLRDYAECYNLKGVTTRILNK"
     gene            24659..25375
                     /locus_tag="KRO40_002014"
     CDS             24659..25375
                     /locus_tag="KRO40_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH2092833.1"
                     /translation="MINLIFDVDDTLYNQLTPFYTAYNKVFSSIKDISIEDLYMSSRK
                     YSDEVFHMTENGEMPIKEMHIYRIMKAFEELGNSITEKDAQSFQDEYIYQQSQITLIP
                     EVERILNFSKERNINLGIITNGPSNHQRMKLKQLNIENWVDKSNIFISSEVGFSKPDT
                     NIFRVAENVMNLDRENTYYVGDSYRNDVLGAKKAGWKSIWLNHRGYEVEELFYKPDFV
                     ILEHKDLISLFIKICSYKNM"
     gene            complement(25570..25863)
                     /locus_tag="KRO40_002015"
     CDS             complement(25570..25863)
                     /locus_tag="KRO40_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein"
                     /protein_id="HBH2092834.1"
                     /translation="MRNMIENLIKNNTYIDDKVIMLSMLSSAKASANMYLNSALTSST
                     PELRAIYSASLTQMVEGHTALTELSINKGWVKPYDKPIQQLTCSYKESQNVID"
     gene            complement(25869..26084)
                     /locus_tag="KRO40_002016"
     CDS             complement(25869..26084)
                     /locus_tag="KRO40_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092835.1"
                     /translation="MRILSETEKISLAAIIKMESDGLLMQRAINMLISDEDLKRQSES
                     SILATEGRIKAIQQFIVENEILISEEV"
BASE COUNT         9995 a         2937 c         4559 g         8902 t
ORIGIN      
        1 atgaatttct ataagtttaa gtgggtataa acttatagaa attcattttt tatttaaggt
       61 aaaaatttaa agtaaaatat tattttacat aataataacc ttataaattt tgaaattact
      121 tatctttgtg ttaaaataag taaaatgcac atattagagc taagttttta agtaaataaa
      181 caaagtgaaa atataaatat taaggagatt tggtatatga atgtttatga aaaaggtaat
      241 ggagttatac tagaaggagt aacagatttt gacccagtac atatatttga gtgtggtcaa
      301 tgttttagat ggcacaaaca agaagatggc tcatacactg gagttgcaaa ggggagaata
      361 ttaaatgtca aaaaagagaa tgataaaata tatttaaata atactaattt aaaggagttt
      421 aacagcattt ggtataatta ctttgattta ggaactgatt atacagaaat aaagaataag
      481 ctaaaaaata tggatgaata tttaaataag gctactgaat ttggatgggg aataagaata
      541 ttaagacaag atggatggga aatgcttata tcatttataa tttcctctaa taataggatt
      601 cctatgatac aaagagctat agaaaattta tcaagaaagt ttggtaagta tataggtgaa
      661 tatgaaggca atgaatacta tgcattccca acaccagaag aactaaataa ggcctcacaa
      721 gaggaaataa gagcatgtca aacaggtttt agagataagt acataaaaag tactacacag
      781 gcagttatag agaataatga tgaggtatct gaatatacaa atttaagtac agaggattgt
      841 agaaaagagc ttttaaaatt taatggagta ggaccaaaag tatgtgattg tattgcatta
      901 tttggtatgc aaaaatatga ttcttttcca gttgatgttt gggttaagag agttatgcaa
      961 gaattttata tagatgaaga catgagttta cctaaaatga gaacctatgg aatcgataaa
     1021 tttaaagaaa tgtctggatt tgctcaacag tacttatttt actatgcaag agaactcggt
     1081 ataggaaaat aaattaaggg ggagaaatta tgggagtaat aggaacaata tttctgttct
     1141 atttaattat atcatatcta gctggagcca taatttctgt gattatatta cttgaaaata
     1201 gagaccctgc aaaaacaatg tcttggctat tgatgtttat tatatttcca ggtgtaggtt
     1261 taatgatata tgctatttca ggtagaaata ttagaaaaag aaaattattt aagactcaaa
     1321 aactagctaa taatataaaa gaaaagaaac tatttgatac attagaaaag ataacagaaa
     1381 tagttgaatt agaaaaagaa tctataaaac aaaataagct tttaagagat gaagaggatg
     1441 gtagttatag aaaaagggta ataaatatgt tgttaaagac tggtatgttt ccctttacta
     1501 aaaataataa agtggatgta tttgtagatg gaaatgaaaa gtttaaaaga cttatagaag
     1561 atataagaga agctaaagac catattcatt tagagtactt tatcatcaaa gatagtgaaa
     1621 taggtagggt gttaaaagaa gaacttataa aaaaggctaa agaaggcatt aagataagaa
     1681 ttttatatga tgatgtagga tgctggagat tttggtttaa tagaaaattt ttccgagaaa
     1741 tgagggaagt aggtatagaa attgcagcat ttttacctac aaaatttcct ataataggag
     1801 ggaaattaaa ctatagaaat cacagaaaaa ttgttgttat tgatggaata attggatata
     1861 caggtggaat aaatatagga gatgaatatt taggcaaaaa tgataagttt ggatattgga
     1921 gagatactca tattaggatt aagggtattt ctgtatacat gcttcaaatg acatttctga
     1981 ttgattggta ttatacgaca aaagaagtat tagtgactaa aaattatttc ccaagtgtag
     2041 ggaatgttgg tgaaagtatg atacaagttg ttgcgagtgg tccagacagt gactgggaag
     2101 atattcatta tgcttatttt tctgcaatat gtcaggctag aaaaaatgtt tatatagaaa
     2161 ctccatattt tattccagat gaaagtctac taaaagctat aaagagtgct gctcttagtg
     2221 gagttgatgt gagaataata tttcctaaaa ttgcagacca caagatagta aatatagcat
     2281 cttattcata ttttgaagaa atattaagag caggtggtaa agtttattta tataataaag
     2341 gatttataca ttctaaagtc gtaataatag atgataaaat tgcttctgca ggtacagcta
     2401 atatggattt aagaagtttt atgcttaact ttgaggtaaa tgcatttatc tatgatgaag
     2461 aagttattag ggtaatgaca gatgatttct ttgaggattt aagttactgt gaagaactta
     2521 atttggaggt atttaagaat agaaatatca tacaaaaaat caaagaatct gtagcaagat
     2581 tattttcacc aatattataa aaaattatta aaaaaggtat tgaaaattat gtgtgattgg
     2641 tatattataa taattgttag cactctatta gatagagtga taataaataa aaagtatata
     2701 tataaatcta catatataag tagtattaat ttaaaaataa ctaaaaacat aggcgaacta
     2761 gtctatactt aatattttag gaggcgtgaa taatgaaaat aagaccatta gctgacagag
     2821 tagtaattaa aaaagtagaa gcagaagaaa aaactgcaag tggaatagtt ttaccaggag
     2881 cagctaaaga gcaacctcaa atagctgaag ttgtagaagt tggaccaggt ggaatagttg
     2941 aagggaaaga aataaaaatg gaattgacag tgggagataa ggttatattc caaaaatatt
     3001 ctggaacaga agttaagata gaaggacaag aatacacaat actaagacag agtgatgtat
     3061 tagctgttat tgaataaata tagaataaat ttattaggag gggtttaaaa tggctaaaga
     3121 aattaaattt tcagaggaaa caagaagagc tttagaagct ggtgtaaata aattagcaga
     3181 tacagtaaaa gtaacattag gacctaaagg aagaaatgtt atattagata aaaaatttgg
     3241 ttctccactt ataactaatg atggagtaac tatagcaaaa gagatagaac tagaagatag
     3301 atttgaaaat atgggtgctc aattagttaa agaagtagca actaaaacta atgatgtagc
     3361 tggagatggt actacaactg ctacagtttt agcacaagct ataataagag aaggtttaaa
     3421 gaatgtaaca gcaggggcta acccaatact tttaagaaaa ggaatacaaa aagcagtaac
     3481 agtagcagta gaagaattaa aaaatcaatc aagaatagta gaaacacaag aggctatatc
     3541 tcaagttgct tctatatctg ctggtgatga agaagttgga aaattaatag cagaagctat
     3601 ggaaatagta ggtaaagatg gagttataac tgttgaagag tctcaaacta tgaatactga
     3661 attagatgct gttgaaggta tgcagtttga tagaggattt gtttctgcat atatggttac
     3721 agatgtagat aaaatggaag cagttttaaa tgacccatat atattaatta ctgataaaaa
     3781 aatatctaac atacaagaat tattaccagt tcttgaacaa atagttcaac aaggtaaaaa
     3841 gttattgata atagctgaag atgtagaagg tgaagcatta tctacattag tagtaaataa
     3901 attaagagga acatttgatg tagtagcagt taaagctcca ggctttggag atagaagaaa
     3961 agaaatgctt caagatatag caatacttac aggtgctcaa gtaatatcag aagaattagg
     4021 ttatgattta aaagaagctg atttatctat gctaggtaga gcttcatctg ttaaggtaac
     4081 taaagaaagt actacaatag tagatggttc tggagataaa aaagctatag aagatagagt
     4141 aactcaaatt aaacatcaag tagagcaaac tacttcagat tttgatagag agaaattaat
     4201 ggaaagatta gctaaacttg ctggaggagt agctgttgta aaagttggag ctgctacaga
     4261 agtagagtta aaagaaagaa agttaagaat agaagatgct cttaatgcaa ctagagcagc
     4321 tgtagaagaa ggaatagtag ctggtggagg aactgctttt gttagtgtta taccagcaat
     4381 aggaacacta attgagagtt tagaaggaga agttaaacta ggtgctcaaa tagttaaaaa
     4441 agcgttagaa gagccattaa gacaaatagc tataaatgct ggtcttgaag gtgctgtaat
     4501 tgtgcaaaat gttgttaatt ctgaagcaga aactggattt gacgcattga atgaaaaata
     4561 tgtaaatatg atagaagctg gtatagttga cccaactaaa gttagtagaa gtgctttaca
     4621 aaatgctgca tcaatagcaa gtactttctt aactactgaa gctgctgttg ctgaccttcc
     4681 tgaaaaagaa gatgcaggaa tgccaggaat gggtggcgga atgcctggta tgatgtaatt
     4741 taaaaaattt aaaatataaa ttttaatata aagaactatt tcgacttaga ttttaaactc
     4801 taagttgaaa tagttctttt gtatatatct aatttttgta tatctataaa ttcaatacac
     4861 atatttagat aatcagtatc tagtttgtaa taatatttta gagtagtatt gttatttttt
     4921 aggttatgat tttagatata tattaattaa ggtataattg ttgatagaga ataaatcaaa
     4981 tttaaaagga tgcgataata tggacttaag aaaattgctt gaagaagtta aaaatgaaaa
     5041 tattgatata gattttgcgt tagaaaagtt aaaagattta ccttatgaag accttggata
     5101 tgcaaatata gatcatcata gagaactaag aaatgggtat ccggaagtta tttattgtga
     5161 aggtaagagt gatgagcata ttttagggat tattgataaa atgaatcaaa aaagttctaa
     5221 catattggga acaaggtgca gaaaagaaac ttttctgaaa attaaagaaa tctataatca
     5281 tgctgagtat gaagaggcgt ctaaaattct taagattcaa aatcatgata tagagaatat
     5341 aggaaaaggt aaaattgtga ttgctacagg gggaacttct gatataccag tagcagacga
     5401 agcttatcat acagctaagt ttttaggtaa tgatgttgat agaatatatg atgttggagt
     5461 ggcaggtata cataggcttt taaataaaag acataaaata gatagtgcta gagtaatagt
     5521 agccgttgca ggtatggaag gtgctcttgc aagtgtaatt ggtggactgg ttgatgttcc
     5581 agtaatagct gttccaactt ctgttggata tggagcaaat tttggaggat tagcagcatt
     5641 actagctatg ttaaatagct gtgcatctgg aatatctgtt gtaaatattg ataatggatt
     5701 tggagcagga tatttagcat caatgataaa taaactgtaa atatattgat ataaattaaa
     5761 caaaactata taataaaatt taatttctat tatattttta ctattaaaat tgaggagaca
     5821 tatatgagtg aaaaaatact ttattttgat ataataagcg gtatatcagg ggatatgacc
     5881 cttgcaagtt tattaaattt aggtgtgcct aaggaaattt ttttggagga aattcataaa
     5941 ctaagaatga gcgatgaatt taatataaac atcagctcga aaactgaaaa tggaatagta
     6001 ggtacaaaag tagaagtaat tacaaaagaa aaacatacac atagaaattt agtggatata
     6061 tttgaggtta tagataaaag cactctaaac gaaaatgtaa aatctaaagc aaaaaaaata
     6121 tttatggtaa ttggagaagc agaagcaaaa gttcatggaa ctacaataga caagatacat
     6181 tttcatgagg taggggctat agattcaatt gtagatatag taggagcttc tatattagtc
     6241 gacttacttt gtgtagataa agtttgtgct agtacagtgt ctgttggttc aggatttgta
     6301 aaatgtgaac atggaattat acctatacct gcacctgcaa ctatagaaat tttaaaaggt
     6361 gtgccaatta aattaaataa tgtaaatgga gaatgtacaa ctccaacagg agctgcaatc
     6421 ataaaagttt tgtgtgatga gtttgtagat gagcttgaat tttctccaaa gcaaattgga
     6481 tatggtatag gtcataagaa gtttgaagta ccaaatatac tcagaactgt attaggtgaa
     6541 aaaaaaaaga agaattaatt tatgaaatta gtgcaaacat tgatgatatg tcttcagaaa
     6601 tctattctta tttgtatgaa aaaatattag atgagaaagc attagatatt tatacagaga
     6661 gcatttatat gaagaagaat agaccagcaa caaaactatc aattttatgt aatgaatcag
     6721 atttagaaaa atttattaaa atattacttt tagaaactag tacttttgga gtgagatata
     6781 atgcatataa tagagaaatt ctagagagaa aatttgtaaa attagataca aaatatggag
     6841 tggttacagt aaaactaggg tattataaag gaaaactagt caaggctact ccagaatata
     6901 atgaatgtaa aactatagca aaaaatgaag atattcctat aaaaaaagtg tttgctgata
     6961 taaattttag aataaaagaa gaatttagtg aaaacttatt gacataagta ataaattttg
     7021 ataaattaat attcagcctt attaaataaa agtaaacaga aaaaaatata taaaatataa
     7081 actcactcgt atatgctcag aaatatggtc tgagagtctc taccaagata ccgtaaatat
     7141 cttgactatg agtgaaatta ttataccaaa agacctagtt aagtaaatgt gtaggctgag
     7201 ttaaactccc tatgtgttgg ctataagata aaggtatttt ggaagcctgt atagtaattt
     7261 cacttttgct agaaattatg gaagttacta tacaggtttt ttgtgtaaaa agatttaata
     7321 taatttagac tgtattgtgt taaaataaat atataaaaac tatattatac aaggagagat
     7381 gtaaatttat gaaacatgaa ttagtacttg taatagattt tggaggacaa tataatcagt
     7441 tgatagctag aagagttaga gaaaacaacg tatattgtga aatacttcca tgtactgcaa
     7501 gcatagaaag aataaaagaa aaaaatccta aagggataat atttacaggc ggtccaaata
     7561 gtgcgtattt agaagattct ccaacaatat caaaagaaat atttgaacta ggagtaccaa
     7621 tacttggaat atgctatggt attcaaataa tgtctcatgt attgggtgga gttgtaagaa
     7681 aaggtaataa acaagaaaaa gaatatggaa aaacagctat aacttatgga aaatcatcat
     7741 tatttgaagg aataactaca aatagtgtat ggatgagtca tacagattta atagaaaaag
     7801 ttccagaagg atttactata gttgcaaata ctaatgattg tccagtagca gctatggaaa
     7861 atgtagaacg aaacctatat ggagttcaat tccatccaga ggtagaacac tgtttggaag
     7921 gggacaagat acttacaaac ttcttatata atatttgtaa agtaaaaggt gactggacta
     7981 cagattcatt catagaagat aaaataaaag aattaaaaga aaaaataggc gataaaaaag
     8041 ctttatgtgc tttaagtgga ggagttgatt cttctgttgc tgcagttctt attcataaag
     8101 caattgggga caacttaact tgtatatttg ttgaccatgg tttacttaga aaaaatgaag
     8161 gaaatgatgt agaaagaata tttagagaga aatttgatat aaatttaata agagttaatg
     8221 cagaagatag attcttatct aaattaaaag gagtttctga accagaagct aagagaaaaa
     8281 taataggtga agaatttata agagtatttg aagaagaatc aaataaatta ggaaaaatgg
     8341 atttcttagt acaaggaaca atctatccag atgttataga aagtggacat ggaaatgctg
     8401 ctactataaa gtctcatcat aatgttggtg gaatcccaga agatgtagac ttccaagaaa
     8461 ttgtagaacc attaagagag ttatttaagg atgaagttag aaaaatagga ttagagcttg
     8521 gtatagaaga aggattaata tttagacatc ctttcccagg accaggtcta ggaataagag
     8581 ttataggtga tgtaactaaa gaaaaatgtg atatattaag agaagctgat gctgtttata
     8641 tggacgagct tagaaaagca ggtttatata gagaaatatg gcaagctttt gcaacattac
     8701 cagatgttaa gactgttgga gttatgggtg atgaaagaac atatgcttat ttagttggtt
     8761 taagagcagt tacttcttct gatggaatga cttctgactg gtataagatg ccttatgatg
     8821 tattagaaag aatttctaat agaataataa atgaagttga tggagtaaat agagtagttt
     8881 atgatataac ttctaagcct cctggaacta ttgaatggga ataaaatata gaatgccaaa
     8941 aatccacata aatacaggat ttaaggtctc tcttacttct atgttatact ggtttgatac
     9001 tatcaatatt tgccagtatc ttatggatta ataagcaaaa aacatcctgc tgaatgataa
     9061 attcagcggg gtgtttttat tttgttttag aactcctttg ctctgaaact cgaagtattt
     9121 aacactgatg attttgttat cttttagttc cttttgtgtc atgctctgaa agacaaattg
     9181 atacaataaa aaagtaattt cttaatcatt gatggagata tgtatttatg ttactcttga
     9241 tggtaatttg agtaatattg ttcatagctt tttatattca cttaattaga gaatcatttg
     9301 gtataatcat aaataaactt gatgatataa tagaaaagat ttataattat tagaagtata
     9361 taaaagtatt ttatgtctat gaaatgtatg tctataaaac atatagatga cttttgtata
     9421 ttaatgtatg aatattgata ttatagaaga attgagttgt caatgatact aaatcaaata
     9481 tttatagaag ctggagggat tatgagaaat aaaataatta taggaattac tttttcactt
     9541 gtattactaa tgtctggatg tgcttcaaaa caaacagcag aaataaacgt attagcaact
     9601 actgatttac atggagttat accttatgag ttaacttctt atgtaaaaga agaaagaaaa
     9661 aaagataaaa atctaacttt agtagatgca ggagattttt ttgatagtgg agaagtgttt
     9721 ggttctagca tggatagtta ttttagtgct aggtataagg atattgataa taacactgag
     9781 cgttacattg agacacctat ttcaaaagat atgaaagagg taggttatga tgttgcagtt
     9841 cttgggaatc atgaatttat atccaacaat aaattttatc tagataatat gatatctgat
     9901 tttgagaagc aaaaaataaa tattttatca gcaaatacgt ataaaaaaaa tggagacagt
     9961 tatacaaaac catacataat aaaaaatatt aatacacctg aaggaaacgt aaaactagga
    10021 attttagggc ttactataaa agaagttggt gagaggaaac agtggaaaga tggaaaactt
    10081 gttgactcta agtctttaga actaaaagac caagagggct acaatggtga attgtatatg
    10141 aatgatttag tagaagatgc taaaaagtgg gttagtataa tggaaaaaga gaagcctgac
    10201 attatagttg ctgtggcaca tacaggtgag aaacctaaga aacctagaaa cccaggaaat
    10261 agaatacaag acttagctca acaagttgat ggaattgatg ctatagttgc aggtcataat
    10321 catgttcaaa ttgagcaaca tgattataaa aataaatcag gagaaaatgt tatagttact
    10381 gagccaggaa agcatggaga atgtatttct aagattaatt ttaaattaga aaaaaacaat
    10441 gataaatgga atatagttga caaatctagt aaattaatta aatttgaaaa aaatcaagaa
    10501 agtgataaat ttggagaatt tatttcttca attaataaag taagtaaaga taagaaagaa
    10561 ataagattgt cagaagtaaa gactcctgaa tgggataaaa tatatgtttt taaatctgga
    10621 acatctgcag atgatatata taaaacaata ggatataaat ggagaaatat atcatctcca
    10681 aagggtgatg acatggtgca gattgttgta atgaataata ataagcctgt tagctatgta
    10741 tatggtgaag ctgaagttat gccaattaat ataaaatgtg atgaatcaga gtataaagat
    10801 aatgttgtaa ctatttatcc taataaaaat gataaattta aaattgaaaa aggtaaacaa
    10861 gaatatagta ttaatttaaa acatatacaa tagaaacttt tatcttattt aagtttagat
    10921 tgtacttaaa ataaagtgtg tattatttta aaaattgatg ataattaaaa tcacaacatt
    10981 aaggaatagt acacactttt tatgctaaaa aatagaatgt taaaaaatta aacctttaaa
    11041 ttaaagtaca ttgcttatat tatccaatat tatcttcaaa ggttgtgtga tatttttatc
    11101 cttatgtaat attgctaaca ttttattttc catatctatc ccatctaatt caatcaatcg
    11161 caatttttta tgtaagagtg aatctaataa taaattttct ggcaaaatgg ttatacctaa
    11221 ccctgcttct gcagctttaa taagtgcaaa agaattaaca ctttcccaaa caggataagc
    11281 tttttggttt gaaagagata atacactgtc caaagtattg cgaatggcac ttccttgctc
    11341 acgtaacaat aacggaaacg tgcataactg tcgtagagat aaggcttgtt tagtattggt
    11401 ggtggttatg caatcatacc tttaatccaa gagaaagtag taaatcaaac tggatggata
    11461 agtgagaaaa tgtttacaga tattataact atttcacaaa tgacaccagg gccactggct
    11521 gttaatactt ctacttttgt tggacttcaa attggagggt tttggggagc atttgcagcc
    11581 actttaggtt gtgtattatg tggtgtagta atagctctat ttttatataa tttttttcaa
    11641 aagcatcaga actctactta tatatttgaa atattaaatg gtctaaaatc agcttcatta
    11701 ggtttaatta tctcagctgc ggctacaatt ataattcttg cattatttgg gacgaataaa
    11761 gtgtacttca attctatatt tgagatgcta aactggactg cactaataat cttttttgtt
    11821 acactactga tagtacgtaa gtggaaaatt aatcctattg tgattataat aataagtggt
    11881 atactgggaa tattttttta tttataagtt tttgctaagt aaaggatatc tattttttta
    11941 tatcttaaat ccaaatagcc aataaagtaa ggctatttgg atttttaata aattctgaaa
    12001 aaataatcag aaacccatat aacatttaaa ttatatcact ggttttctac aaaccaatca
    12061 taagcttctt ggcaaaattt ctcactatct atatagtaac tattatgaac attattaatt
    12121 tcaacaagtt tctttttaca ttttagtgaa ttataatatc tatcaaaata ttgggtttta
    12181 aaatatctat catgaagtgt cttaaagaca agagtaggta tgttgactcc atcttttatc
    12241 ttactatctt ctgcaataaa gcattctaac attgtattaa ttatctttgt actatttttc
    12301 caaatatgag gatttttctt ttcaaatatt ttataaaatt cattatcata gacttcatta
    12361 taacctttat atttaggtgg ttttactgtt atgtgaaaat taggaagaaa cttaaagaaa
    12421 aagtttaata atttaacagt gagataggta tagcctactc ctgttgtgtt tttataatca
    12481 acacaagcaa actgagcaaa actttttaac ttattgtctg aacatgcata atattgtgca
    12541 aacataccac caattcccgt attcccatat agatgtatgt tggaagaata atttttttct
    12601 atgtatgtaa tgacagaatc taagtctttt acaattgaat tgcgagaaaa atctttttca
    12661 tatccatcac ttttccctgt tcctgaaaaa tcaaaagcaa atatatttac attatgtttg
    12721 gcaagtggtt catatgcttt ttgcatctca agcgtagtga caataggagt atgtgtaaca
    12781 acaatattca tggatgattt tctggtaata aatgagttac aaaaaatcat tgtatctcca
    12841 tttggtattt ttatatgttt ccaactcatt tgattttcct ttctctatta taaaatataa
    12901 taatttttat gttctgtttt atatattatt catattttat cacagataat atactaaagt
    12961 taattttttt attgtacacc tattataata attcttctat aatataagac attctataat
    13021 tttatattta agttcatgtg tatttaattg tttttatata aaatgtccag taatactatt
    13081 tggatttatt tttatttcat caggagttcc agaagcaaca atttcccctc catttattcc
    13141 actgtctgga cctatatcga taatccaatc agaagcacgt ataacctctg tattgtgttc
    13201 aataattaaa agtgaatgct gttcatttac aagttttcta aaagtaatta acaaattttc
    13261 tatatcttta aaatgaagtc cagtagtagg ctcatccaat atgtacagca ttcgtttttt
    13321 agtttttgtc cctaattctt ttgctaattt tatcctttga gattctcctc cacttaatcc
    13381 taatgtattt tgtccaagct ttagatatcc aagtcccact tcatctaata aggagagttt
    13441 tctatatata tcagagcaat cgctaaaaaa tgtttttgct tctgctactt ccatgtcaag
    13501 tatatctgca attgtctttc ccttgtattg tatagacagt atttcttttt gatatctctt
    13561 accttgacat tcactacaag ttacccattg gtctgccata tattgcagaa taatttttgt
    13621 tttacctaat ccttgacagt ttgggcattg cccctttttg ctattaaagc taaaatagct
    13681 ttcatccaat aatttttgtt ttgcttgtgg agtttcagca aatagagaac gaatttcatc
    13741 aaaaatattg atatatgtag caggtgtaga acggctagat tttccaatag gtgtttggtc
    13801 cattaagata aaatcatcaa tagcatcaaa tccagtaaat tcagtataat ttttatctgg
    13861 gatagatttt tgtttcaatt tttcttctag agcaggaagt aaactgtgaa atacaagaga
    13921 gctcttacca gaaccactaa cacctgtaat agagcacata cagtttaagg gaatttctac
    13981 atcaatattt tttaagttat ttgcatggca tccttttaag cttaaccatt tacttggtat
    14041 agttttattt tgtgaacctg ttttattgta tgtacttaaa tatttacctg ttatagagtt
    14101 tggatttttt ataatttctt gggttgtacc ttctgcaata atgaaccccc cttttgtacc
    14161 agcacttggg cctacatcaa taatataatc agcagacagt attgtatctt tatcgtgttc
    14221 gacaactata acagtattac ccttatctct tagctcttct atcattttga tgattaaatt
    14281 atggtctctt gggtgtaaac caatagatgg ttcatctaaa atgtaggtta agcctactaa
    14341 ttcacttcct agctgacttg ataatcgtac tctctgcagt tctcctccag ataaagttgg
    14401 agatgttcta tctgttgata tatagctaag acctaccttt aatagataac taactcgaat
    14461 ttttaattct gttaagatat catttaccaa agagagctca tttttttgaa gttgatttgg
    14521 taattcacac aaccaattcc ataactgttc tattgtcatt tttgttagtt cagggaagcg
    14581 ataacctttg attgtagtga atctagcctc aatgcacagc aattcgccac cacatgtatt
    14641 gcaaggaatt ttgttcatat attgatgcaa ggtattattt tcagaactag attctctaaa
    14701 aagtctttga atgtggttga ttgctcctga agcaggtctt ctaatctttg attctcgtcc
    14761 ctttgattca aagctaaatt catatatctt atcgtctgta ccatataaga ttgcatctat
    14821 aaaatctctt ggtaattcat tccaaggtat atctaggtct atatttttat cttttgctat
    14881 tgcatataat tcacctacca tccaattacc atttggcttt ttccccctca attttccaaa
    14941 atagtaagtg gctccatcta atattgaaat agttgggtct tttacaatca attgaggatt
    15001 aacttgatag gtaaaaccta atccattaca atcgtgacaa gctccagtat gggagttagc
    15061 attgaaggtt gaagtattta tcttagaaaa aatagtttga caatgcggac aataattttt
    15121 tgtattattc tttttttcta atggaatttt acaatatgga cagtaacttt ttccgattga
    15181 tacaaataac attcttaaat aatcccaaat gcttgtaaga gtaccaacag tagagcgagg
    15241 attttggctt ccttttttct gttcgatagc tatagtaggg gttaatccct gaagtaaatc
    15301 aaattccggt ttttgaagct gttctgaaag ttttgctcca ttacttagat tttcaaaata
    15361 acgtcttttt ccttcttcat aaatcgtatc gaaagctaaa gaagattttc cactaccact
    15421 tacacctgta ataacagtta tttgattttt tggaattgta acctcaacat cctttaaatt
    15481 gttttgcctt cctcctttta aatagataga gcttttatta tgacaaagtg aatttttaat
    15541 tgatttattt attgattttg taaatttgaa tttcttttct agttcaagag gattgcctaa
    15601 ttcttttatt tccgaaatac ctaatatttt taactgagaa aagattgatt tcaaataatc
    15661 ttcaggcaat ttttctatta acaaattaag gtcttctatt tttatatttc cgcttgataa
    15721 tatttctgcc atttcatcta ataaattttt ttctgctctt gttaattgat tgtatttttt
    15781 ggaacttaat tctgtccata aatcccatgg aagcaattct aaaccaatca tattattaaa
    15841 gtcatgtaga agattaccct ttacagaatg ccaacctttc caatttttat tatatccaaa
    15901 gtcatctgga tgagcatgtc cttgccgaca tcttatccag gcttctgaac cagttaaaaa
    15961 accatctgtt tttccgacat catgagtgtc aaaattaatt tgaaaataat ttttttgtat
    16021 gtcatctatt tgtgcatcta ttcttatcca tctctttgtt agagtatcat agtattctac
    16081 aagccagtgg tcttcataag taagctcact ttcaaaataa ttagcaaaac ctgctctcat
    16141 tctagcctca aaacctcgat atcttaggag cgatacaaga agtaaagaat aatctctgca
    16201 cattccaaca agcctttgtt ttgggtttct tggaatagtt agtgggttag aatttatttc
    16261 aaatattctt tttaacattt gaggaattgt acgaagcaat tcctcatcag attgttgctt
    16321 attaaaggat ataccatata attttccttg gtctccatga attactaggc tttgaaccac
    16381 ttttaataac tcaattggag tctttggtaa atcttgatat ttattttcaa attttttagg
    16441 atttgtgatg atgctttgat ttttatagtt atttattttc atttatattt cacctctcta
    16501 aatggatgat ataccctgac atggtgtcat atgcaaggac aatttaaatt ttttgtccaa
    16561 aatttaaaaa taaataaaaa atgatacagt gataaattgt aatacaaata tagtttcaaa
    16621 ttgcatataa tataattatt taataaaacc attatctatg gaatgttaat gaaatgttaa
    16681 gatggcattc ttgaatatta agaaatagaa tactataata tagtgtgaag gattcttagt
    16741 aaaaaaattt gtaagtgtta atatacatta aaaaataggt ttataatttg gaggaaaaaa
    16801 atgaaattat caaggtataa gaaaaatagt ttagttctgt ctataatttt atgttcactt
    16861 attatttcaa tccttgtaat tactgttttt aataccgtaa aactacacaa tatatctaat
    16921 aaacaatcta aaaactattt aaatgatgta tctacacaga ttgtaatgaa tgttgattct
    16981 aaaatcaaat ttattttatc cgacttaaga ataatggcag attttattaa gcaatatgaa
    17041 ggtgatagtc gatatgagta tttatctaaa agaaagacta gttataagta ttatgatgtt
    17101 ggaataatag atttagaagg taaagctgag tttttaagtg gaaaaaagtt tgacttaaag
    17161 aatactgctt cctataaaaa aggaattgaa ggtaaagaat actcagaagt aatagagtca
    17221 atgggttttg ttctttatag tgtacccata tttaatgata atcatgaagt atctagtatt
    17281 ttaataggtg tatccaataa agaaagtatg aatgagattc ttaatataga taactttaat
    17341 ggagaaggaa ctattgaaat tattaatagt aagggaaaac ctcttttcat aggaaaaaat
    17401 actgaattaa taaaagacct tagccataaa tataaggatt ctacagatga accttgggca
    17461 caaaagatgc ttaatgattt taaaaatgat aaatcaggga atattacaat aacctcatca
    17521 aaaggtgtac aatgcttatt gacttatcat ccaattacaa gaggtttaaa tgattggcat
    17581 tttcttctca tagtacctga agatgctgta cttggtgaac ttaataagtt aaattctttt
    17641 acaataacaa tgacatttat aattacatgt attattggaa ttataacatt aattttatat
    17701 attataagaa gaaaatatgt aaatcaaata gaaaatattg catatttaga tagtataaca
    17761 aatggcataa attcaactaa gtttagtatg ctagtcaaac ctttaatttc agaatcacct
    17821 gatagtactt atatgatgat agcaatgaat ataaaagatt ttaagctaat aaatgattgt
    17881 ttcagtagtg aaaagggaaa tatgacacta aaacatcttt acaatatttt gtataaaaac
    17941 attgatgaaa atgaagaatt tgtgtgccgt catgatgcag accttttcta tttgcttatt
    18001 aagaatagac cagtgttaga agccctggag ttattatata aaatagaagc tgacacaaat
    18061 tattttaata aaaataggga aaatccatac tttttaagac tatcagtagg tatttacaca
    18121 attgaaaatc ataatgaaga tttaattaca atacaagacc atgcaaatac agcaagaaaa
    18181 agctttaata aaactcatca aagtgatttt tctttttata gtgatataga aagaaaacga
    18241 ttaatatctg aaaaggaaat ttcaaattta atggaaaaag cccttgaaaa taaagaattt
    18301 tttatgtgct tacaacccaa aattgatata aaaagtggaa aaattagtgg agcagagtct
    18361 cttgtgcgtt ggaaaaattc agaaaagggc ataatttatc caagtgattt tattcctctt
    18421 ttcgaaaaaa gtggatttat atgtaagtta gatttatata tactagaaga aacatgcaaa
    18481 ttgatttcta agtggataaa agaaggtaaa gaagtgttga gaatttctgt taatgtatca
    18541 cgtcaacatc tgaatgataa attgttttta gaaaaatata agcatatatg caataaatac
    18601 aatgtaccaa catgtctgat agatttagaa cttaccgaat ctattttctt agaaaatcca
    18661 gaagctatag atataataga ggatattcat tctaatggat ttaaatgttc tatagacgat
    18721 tttggatttg ggtactcatc attaggaata ttaaaggatt ttaaagttga tataattaag
    18781 ttagaccgtt cattctttgt tagcaaaaat aatatagacc gtggtaaggt agttattaag
    18841 tctattattg aacttagcaa aaggctaggt atgaaagtaa ctgctgaagg aattgaagaa
    18901 ttagaacaag ttgagtttct aaaaaatgtg ggatgtgatt atattcaagg ttatgttttt
    18961 tcaaaaccat tattaatttc tgattttgaa aattttgcat atgaaaataa taaaattaaa
    19021 aatatccatt attaaatgta caagataaaa aatttaggca agttatataa ttaaaaatat
    19081 aacttgtctt ttttatttat atatttaata aaaatatatt tgcagatttt gtaaaaataa
    19141 ttttcaaatg ttgtaagttg tggctaaagc tttattgtat tattctgaat atagaaagat
    19201 agttactgtc ttagataaaa actgaaacat acataataat ataaaatttg ctatattaat
    19261 aactctaatt attttggaag gagggaaaat atgataagtg ggagaatgtt actcatcatg
    19321 aattttctaa aaggaaaaaa taagacaagt tacaaggata ttagcaaaca acttagtata
    19381 gaagaaagaa aagttagata tgatataaat aatttaaata ttgttttgcg ttcattaaac
    19441 aagtcagtaa tacaaaagat gaacaaaggt gtgttaatta ttcctgatga cttccaagta
    19501 gtatgtataa ataataacga atatgtattt tccttaactg agcgagtatc tattatgaaa
    19561 attatatcaa tgtttaaaat agataatcta aacttagaaa aattaagtaa agaatttcag
    19621 gtttctagaa gttcaattaa aaatgacctt aatgttttgt caagtgaatt agaaagaaac
    19681 caaataacta ttacttatga taaatctttt aaaataagtg gagaagaaga cattatatat
    19741 aagcaaagat tgaacatatt aaaatcgtat tcttatcttt ttggtaagga aaaatctgat
    19801 ttaagtgtat ttgagaagta tttagtgaat gtaattgaaa aaatattcaa agggatttat
    19861 ttgattgata tatataattg gtctatgaat ttattattgc aaatgggatg gactttaaat
    19921 gatgaatctt ttacatggta tgtgtcaaat attttccttt ttacatggta tatacattca
    19981 gatgaaaaac atcctttaga atctgcttca ttaagtgagc cgtgttttga aaataagttt
    20041 gaccaagaat ttgaaacaat tattcaaaaa aagttgacta aggaacaaat ttttctgtta
    20101 aagagttttg tattttttac aaataaatat gcaagtttaa acgaggatat ggatttgatt
    20161 agtacagaaa ttatagttca agatctaatt tacaatatgt cagaaatatt agagattagc
    20221 tttaaagaag atatgattct ttataaagga ttactcaatc atattgcccc attgatagag
    20281 agaatcaaac agaatataca gatttatgag gaattacttc atgtaatacc agataaatat
    20341 caatatgtac ttgaagctac taaggtttct attcaaaaaa acagagtttt aagtcaaata
    20401 aagaatgaaa atgaaacaat acttttggca atacatttct taggaagtat acatagaaat
    20461 gagaggaata actacaaaaa tatattgtta gtttgtggat ttggatatgg tgtaattgct
    20521 atgttaaagg atagtttagt aaatgattac cagataaata tagtagagag tattccatca
    20581 tataagttac aagattataa agaatgggaa agtattgact tcattataac aacatcaaag
    20641 atagtaatag acttgcctaa aacaattatt gagataaatc catttttaca agaagaggat
    20701 tatttgaagt ttgaagaaaa agggataaaa agaaagaacg tcttaactaa ttatatgtca
    20761 ataaaaaaaa ggttggactt tttagaagaa gatgcccaaa aaagagtatt aagtattata
    20821 tgtcaagaac ttggatacag tgatgagaga atattattta gacaacttaa tttaagtgat
    20881 ttaataggga ttgataccat aaggataatt gatggagata tgaaatggga agatgctgta
    20941 aaatttagtt caaacatact tgctaattgt gattttgtat cagcacaata tgctgagaat
    21001 attatagata ttttaaaaaa tgtgggtttt tatgctgtaa aagataacga atttgcttta
    21061 ctacatggca atgatagttc attagtcaaa gtaagttcga taagtttatt aatatgtaaa
    21121 gaagcagtta gttttggaga taaaaaggtt aaaatcatat tttgcctagc aagcagagat
    21181 aaaaaagagc aaattcctgc aataattaat ctaactaaaa tggtttataa gactaatttt
    21241 attgctatgt tagaaagtgc aaagacaaaa gaagaagcag aagttttaat tcataaatat
    21301 gagaaggagg tcactgtatg aataaattag ttaatgtaaa atgttcattt aaaatacatg
    21361 ttaattcaaa agaagaagcc attatatcgt tagttgatgt agtgtcaaaa gaaggatatt
    21421 taatagataa aaatcaattt ttaaaagatg ttttaaagag agaagaaaca ttgtcgactt
    21481 atattggaca tggtataggt cttcctcata gtcaaagtgt aggtgttaaa aactcttgta
    21541 ttacaatagg aaagcttgat actcctattg aatggacaga agaaggagaa aaagtggatt
    21601 taatattttt gatatcagta acaaaagaca atgaaaataa tcttcattta aagattttat
    21661 caaaattagc acgtttattg atgcatgaaa gttttagaaa tcaaattaga tgttcagatg
    21721 aacaaactgt ttataatctt ataaaagaaa aaatagagga ggaagattaa aatgagaatt
    21781 ttaaagtttt tgcaaaaaca tcttatgaca gcaacatctt atatgattcc atttgtggtt
    21841 gcaggaggaa tattatttgc tttatcagta actctaagtg gacaagctgc tgttcctgaa
    21901 acaggctggt tggctaaact gaatcaaatt ggagctgctg gcttggcttt attcattcct
    21961 atattaggtg gatatatagc atttagtatg gcagataaac caggattagc tccaggtatg
    22021 ataggtgcat atttagcaaa agaagtaaat gcaggtttta taggtggtat catagcagga
    22081 tttatagcag gatttgttgt tttacaatta aagaaaatta aattagctcc tacaatgaga
    22141 actttaggtt ctatatttat ttatcctttg attggtacat tgattacagg tggtataatt
    22201 gtatttttaa ttggagaacc tatagcttct tttatgacat ggatgacaaa ctggttaaat
    22261 ggaatgtctg gtgtttctaa aattccttta ggtggaatct taggaggaat gatagcctca
    22321 gatatgggtg gtcctataaa taaggttgct gctacttttg cccaaactca agttgacaca
    22381 cttccatatt taatgggtgg agttggcgtt gcaatttgta tacctccaat tggtttagga
    22441 ttagctacat tattgtttcc aaaaaaattt agcaaggaag aaagagattc aggtaaagct
    22501 tcactattaa tgggatgtgt tggaattaca gaaggagcta ttccatttgc aacatcagat
    22561 ccagttagag taataccttg tattatggct gggtcgatta taggaaatat tatggctttt
    22621 ttattaggat gtttaaatca tgcaccctgg ggaggcctga tagtattacc tgtagttgac
    22681 aataggttgg ggtatattgc atcagtatta actggagcag tagttgttgc agtattaatg
    22741 aaattagtaa aaaaagacgt gaaagaagat gaagaaattg aagaagattt agatgaatca
    22801 attgaattaa tatttgaaga attataaata taaatggaag gaatttgtat aaaaaagtaa
    22861 atataaaact ataaatttaa aggagataag aatatgaaaa ttgtagcagt aacatcttgt
    22921 cctagtggag tagcacatac ttacatgtcg gctgaatcac ttgaattatc agccaaaaaa
    22981 tttggtatag aaataaaggt tgagactcaa ggaagttctg gaatagataa tgaattgtca
    23041 cttaaagata ttgatgaagc aacttgtgta atattgacta atgatgttga gattagaaac
    23101 atggaacgtt ttaagggaaa gaaggtagta agaatgagtg tatctgagat aattaagaaa
    23161 tctgatgcat taattaagaa aataaaagat acttttcaat aaaaattgat ttattttaca
    23221 tataactcaa agatgttttt aaagaaattt ttattaaaag catctttgaa aatatcttaa
    23281 aaatagaata aaaggagata tagtcatgaa aaagttacca ataaagactg tcgtacaaag
    23341 attactaaac ttacaagaag aggggaaaag tgcaactctt ttaggaattg gtcctatgtc
    23401 accaaacttg ttacaagcaa gttttgaact agcaaaagat gatgattttc ctttaatgtt
    23461 tatcgcaagt agaaatcaag tagatgcaga tgaactaggt ggcggttatg taaatggttg
    23521 gaatcaggaa acttttacaa aagatattaa gaaggttgcc gacaaagttg gatttgatgg
    23581 tttatattat ttatgtagag accatggtgg gccatggcaa agagataaag agagaaatga
    23641 ccatttgcct gttgatgaag caatggagtt aggaaaaaaa tcttatttag cggacattga
    23701 agcaggtttt gacctattga tgattgaccc tacaaaagac ccatttgaaa ttggaaaagt
    23761 aattccacta gatgtagtac tagaaagaac tgtagaatta attgagtatt gtgaaaacga
    23821 gagaaaaaga cttaatctac cagacatagg ttatgaggtt ggtacagagg aaaccaatgg
    23881 aggtctgact tcaactgaga cgtatgaaac atttataact agactaaagg ttgaacttga
    23941 taatagaggt ttgccaatgc caacatttat agttggtcaa actggtactt taactagaaa
    24001 gacagaacaa gtaggaattt ttaattttag aaatgcttat gatttagctc aaatggctaa
    24061 gaaatatgga gttggtttaa aagagcataa tggcgattac ttagatgatg taactttatt
    24121 agaacatata ccatctcaaa ttattgctac aaatgtagct cctcaatatg gtactgaaga
    24181 aactagggca tatttaaaat tagcagaagt tgagtgtaaa ttagaaaaag agggcttagt
    24241 tgagaaaact tctaatatca gacatgttct tcttgttaat gcaattgaat gtggacgttg
    24301 gagaaaatgg gtagtaggag aacaaaaaaa tctaactact gaagagatat ttaaggatga
    24361 agttttatct aatgaaatac tagatattgc aggacattat acatttaata atgatgatgt
    24421 taaaaaagaa atagaagtgc tttatgataa tttaagtaag aataatattg atggtcaaag
    24481 atttgttgta gaccatatta aacgtccttt gcgtgattat gcagaatgct ataacttaaa
    24541 aggtgttact acgaggattt taaataaata ataggactta tagtggtgag tattgttata
    24601 ctaggtattt atagttataa ttatacttac cactattaaa tttaggagga ctaatatttt
    24661 gattaattta atttttgatg tagatgatac tttatataat caattaacgc ctttttacac
    24721 tgcatataat aaagtgtttt cttcaataaa ggatatttct attgaagatt tatatatgag
    24781 tagtagaaag tatagtgatg aggtatttca tatgactgaa aatggagaaa tgccaatcaa
    24841 agaaatgcat atttatagga taatgaaagc ttttgaggag ttgggaaatt ctattacaga
    24901 aaaagatgca caaagttttc aagatgagta tatatatcaa caatcacaaa ttacactaat
    24961 accagaagtt gagaggattt taaatttttc taaagaaaga aatattaatc taggaattat
    25021 aactaatggc ccatcaaacc atcaaagaat gaagttaaag cagttaaata ttgaaaactg
    25081 ggttgataaa agtaatattt ttatttctag tgaggttgga ttttctaagc cagatactaa
    25141 tatttttaga gtagctgaga atgttatgaa tttagataga gaaaatacat attatgtggg
    25201 tgattcttat agaaatgatg tattaggtgc taaaaaagct ggttggaaga gtatatggtt
    25261 gaaccataga ggatatgagg tagaagaatt gttttataaa cctgattttg taattttgga
    25321 acataaggat ttgatatctt tatttataaa aatatgtagt tataaaaata tgtagtaaaa
    25381 aaatgttaat aatagaattg tataaaataa ttaataataa ctatataaaa ttatatgttt
    25441 agattgtgag caatctattt tatattaaaa atagattatt tagaagaagg ggaaatctta
    25501 aaaaaatttg aatatcccct ttttattatt taattaaaat gaaatagtta gaaatatatt
    25561 ttatttagtt tagtcaataa cattttggga ttctttataa ctacatgtta actgttgaat
    25621 aggtttatca tatggtttaa cccatccttt attaatactt aattctgtaa gtgctgtgtg
    25681 accttctacc atttgagtta atgaagctga atatatagct cttaattcag gtgtactact
    25741 tgtcaatgca gaattaagat acatattggc agatgcttta gcagatgaaa gcatacttaa
    25801 cattattact ttatcgtcta tataagtatt gttcttaatt agattttcta tcatatttct
    25861 catgttatct atacctcctc agaaattagt atttcatttt caactataaa ttgttgtata
    25921 gctttaattc ttccttctgt tgctaatata ctagattctg attgtctttt taggtcttca
    25981 tctgatatta acatatttat tgctctttgc ataagtaatc cgtcagactc catttttata
    26041 attgctgcta aagatatttt ttcagtttct gaaagtattc tcatttaatc atctcctata
    26101 ttgtaattta tgctttaata gtatgtcttt cttttcaagg aaataaccat tacacttttt
    26161 tacagtattt tatattctct ttatatcaaa atttagtcga cctaatatat taatataatt
    26221 ttgtaggata tttatcatta aatatctata aaataaatta tttgaatatt cataaagcaa
    26281 aatttatttg tatgtacttc ttcaagagtc aatatgagtt ttttcaaaaa attaattttt
    26341 atgataatca ttaagggcta tatttttctt aaagttgtga ttatcattat taa
//
LOCUS       DAEQCW010000048        26249 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.048, whole genome shotgun sequence.
ACCESSION   DAEQCW010000048 DAEQCW010000000
VERSION     DAEQCW010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26249)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26249)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26249
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.048"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(258..401)
                     /gene="scfA"
                     /locus_tag="KRO40_002017"
     CDS             complement(258..401)
                     /gene="scfA"
                     /locus_tag="KRO40_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="HBH2092836.1"
                     /translation="MENKHVKTLSQATLKQSAAKGGCGECQTSCQSACKTSCTVANQE
                     CER"
     gene            complement(467..829)
                     /locus_tag="KRO40_002018"
     CDS             complement(467..829)
                     /locus_tag="KRO40_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04086 family membrane protein"
                     /protein_id="HBH2092837.1"
                     /translation="MGKSNYIFKGLGYAYIITLAVLLVYNLFLTFTDIGGDNITMVSS
                     FITTISAAIGGFYTSKHMKEKGLMYGLLVGLLYIVCIFLTVFLAQEKFVFEIGMIYKL
                     LLISAAGGIGGVLGVNFK"
     gene            complement(887..1180)
                     /gene="yajC"
                     /locus_tag="KRO40_002019"
     CDS             complement(887..1180)
                     /gene="yajC"
                     /locus_tag="KRO40_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HBH2092838.1"
                     /translation="MPQQQIIMSIGLWVVVIAIFYFLMIRPQKKKDKQLKEMRSSLSV
                     GDKVITIGGIVANVAKVEDDVVILELGPNRTKVPFEKWAIGTVKSKKEEIEED"
     gene            complement(1314..2435)
                     /gene="tgt"
                     /locus_tag="KRO40_002020"
     CDS             complement(1314..2435)
                     /gene="tgt"
                     /locus_tag="KRO40_002020"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HBH2092839.1"
                     /translation="MYAVRYELIKTCKQSGARLGRLHTPHGIIETPIFMPVGTQATVK
                     SMTPEELKEIGSQIILSNTYHLYMRPGHELIKRAGGLHKFMNWDKPILTDSGGFQVFS
                     LGPLRKIKEEGVEFRSHLDGSKHFLTPEKAMEIQNALGSDIMMAFDECAPYPSDREYV
                     KNSLERTTRWLKRCKDAHNNTDKQALFGIIQGGMYKDLREQSAKEITNIDLPGYAIGG
                     LSVGEPKPLMYDVLEHTTPLMPKDKPRYLMGVGSPDDLVEGVIRGVDMFDCVLPTRIA
                     RNGTAMTSQGKVVVRNATYAEDFTPLDPECDCYACKNYSRAYIRHLIKANEILGARLI
                     TTHNLHFLLNLMKQIRQAIMEDRLLDFRNEFFAKYGYEI"
     gene            complement(2514..2999)
                     /locus_tag="KRO40_002021"
     CDS             complement(2514..2999)
                     /locus_tag="KRO40_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092840.1"
                     /translation="MHSLQKQKKNNPILKIAFIFERVLAVVVLIAVFLGTIDVLRLMW
                     GAYIVDFQNPVQYSQLNDFLAQILLLVIGVELVVMLSLHIPGAFIEALLYAIARKMLL
                     LPKNEGMIDVLIGVIAIAGLFAIKKFLVTKDKSALNIMSIHDEEAIKEQQNKEDEDKS
                     I"
     gene            complement(3011..4036)
                     /gene="queA"
                     /locus_tag="KRO40_002022"
     CDS             complement(3011..4036)
                     /gene="queA"
                     /locus_tag="KRO40_002022"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HBH2092841.1"
                     /translation="MKTSDFKFDLPQELIAQVPIEDRASSRLMVLDKETGNIEHKVFR
                     DIIEYLNPGDCLVLNNTRVIPARLIGEKLETGGKIEFLLLKRTEEDTWQALVKPGKRA
                     KVGTKFSFGNGKLIGEVVDLSDEGSRIIKFHYDGIFEEILDELGNMPLPPYITARLDE
                     KERYQTVYSKHNGSAAAPTAGLHFTEELLNKIKEKGVDIAFVTLHVGLGTFRPVKVED
                     VLNHKMHSEYYMVSQEAADKINRAKENGKNVICVGTTSCRTIESACNEYGKMKETSGW
                     TEIFIYPGYKFKVLDKLITNFHLPESTLIMLVSAICGKDNVLNAYNEAVKERYRFFSF
                     GDAMIIK"
     gene            complement(4354..5373)
                     /gene="ruvB"
                     /locus_tag="KRO40_002023"
     CDS             complement(4354..5373)
                     /gene="ruvB"
                     /locus_tag="KRO40_002023"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HBH2092842.1"
                     /translation="MQGFEDENRIITSTMKMEDIDIENSLRPKTLEDYLGQEKSKEQL
                     SIFIEAAKSRNEQLDHVLLYGPPGLGKTTLASIIANEMGVNLRITSGPAIERAGDLAA
                     ILTNLNENDVLFIDEIHRINRSVEEVLYPAMEDFCLDIIIGKGPSARSIRLDLPKFTL
                     IGATTRAGMLTNPLRDRFGVICKLDYYTVDELSKIVLRSSSILDAEIQSNGALELAKR
                     SRGTPRIANRLLKRVRDFAQVRADGKITDKVAKDALELLGVDSLGLDFVDEKLLMTII
                     EKFRGGPVGLDTLAASIGEDRNTIEDVYEPYLLQLGFINRGPRGRVAMPLAYEHLKIP
                     YPNEK"
     gene            complement(5480..6082)
                     /gene="ruvA"
                     /locus_tag="KRO40_002024"
     CDS             complement(5480..6082)
                     /gene="ruvA"
                     /locus_tag="KRO40_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HBH2092843.1"
                     /translation="MYSYIKGTVEEIYIDSIVVENNGIGYKINVSSNTIMNLQVGEAT
                     KIYTKLIVREDDMSLCGFVSREELKMFELLTSVSKIGPKVALSILSFASPAQLGAYIL
                     SEDIGKLSKAPGVGKKTAERIVLELKDKVDKNNIEFEPTLLSQKPTLISQDESVDALV
                     ALGYTLSESKEAVQKCKKDGMNTEAIIKKALTYIMSKSLK"
     gene            complement(6075..6584)
                     /gene="ruvC"
                     /locus_tag="KRO40_002025"
     CDS             complement(6075..6584)
                     /gene="ruvC"
                     /locus_tag="KRO40_002025"
                     /EC_number="3.1.22.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="HBH2092844.1"
                     /translation="MIILGIDPGIAIVGYGIIEYKNSKFKVIDYGAVTTPAHMNISRR
                     LELVYKGIDTIVKNYNIDEVGMEELFFNKNVKTAITVAQARGVTMLACAHNGKPVYEY
                     TPLQVKQGVVGYGRADKAQVQQMVTSFLSLKKVPKPDDVADALAVAICHAHSNKLEKT
                     LKNIGGKYV"
     gene            complement(6912..7541)
                     /locus_tag="KRO40_002026"
     CDS             complement(6912..7541)
                     /locus_tag="KRO40_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092845.1"
                     /translation="MFEKKKKELFPWKISALILVGVFVLSSGVYIGTRLKHNGVQTGE
                     VVSTSANMNEKSKEAFGLNKNCEVWLQSEGENETNYKRTLTMAGIVPESLLDKTKSEI
                     VSYFKKEYPTKKIKSMDKNEIILVESKYSDNKDVQAMDVTIKGKYTIENDNGNIALYK
                     YDDSGSKTLVEKTKIRVDSLPKTVQDEIKKGVVMDTEEEAYSRLEDFAS"
     gene            7744..8067
                     /locus_tag="KRO40_002027"
     CDS             7744..8067
                     /locus_tag="KRO40_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBH2092846.1"
                     /translation="MERINCNVINCSHNNSHICYADKIFINGEKAHNDRHTCCSSFLD
                     ESIYSNLSSNVNNRNCEELVCTVKNCKYNKDGSLCTLDNILVAPETDRVNLYIETCCS
                     SFECK"
     gene            8335..9189
                     /locus_tag="KRO40_002028"
     CDS             8335..9189
                     /locus_tag="KRO40_002028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092847.1"
                     /translation="MSTFYIQFLYFVIYSFIGWCCETTYCSVLQKQFVNRGFLNGPFC
                     PIYGFGALAIVATLTPFVHNIPLLFLFSIIITSIMEYCTSFILEKIFNMTWWDYSKHK
                     FNIHGRVCLENSLMFGVLSLIVMLIVHPIVVDFINSISKNVLFIFAISIEIYFVLDLV
                     ITVHTILQLNGKLKQINLIIKELKDKKEYYKLITQETIENKLESLVENRLDTLEDRFE
                     ILKEKENYRYAKNRIDELKNKLNTLLSNHKLLHRRIIKAFPNISSNKHTDILNKIKEN
                     IKSIKKDK"
     gene            complement(9375..10811)
                     /locus_tag="KRO40_002029"
     CDS             complement(9375..10811)
                     /locus_tag="KRO40_002029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyacid dehydrogenase"
                     /protein_id="HBH2092848.1"
                     /translation="MREVKPISIDILNTFKQVDEDRLNKLLADELKHLDRKIVVLDDD
                     PTGVQTVHDISVYTDWDKDSMEQGFNEKNSMFFILTNSRGFTVAQTTKAHKEISKNIV
                     DVSKKVNKDFIIISRSDSTMRGHYPLETNLLKSEVERLSGKLFQGEIIMPFFKEGGRF
                     TIDNVHYVKEGEILVPAGMTEFAKDKSFGYKSSDIGEWCEEKTKGKYKSSDMIYISSK
                     ELRELNIEAITEKLKKAEGFNKIIVNATDYVDVKVFTIAFIRAVNSGKEFMFRSAAAI
                     TKVLGGVSDKELLTKDELVSKGNTNGGIILVGSHVNKTTQQLEELKNCKYPIEFIEFN
                     QHLVLQENGLKNEVKRVIKVVEEKISRGKTVAVYTRRERFDLDTNDKDKQLMISVEIS
                     DAVTSIIGMLNVRPNFIIAKGGITSSDVGTKALRVKKATVMGQIKPGIPVWMTGKESK
                     FPNMPYIIFPGNVGEISTLRESVEILMG"
     gene            complement(10882..12264)
                     /locus_tag="KRO40_002030"
     CDS             complement(10882..12264)
                     /locus_tag="KRO40_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH2092849.1"
                     /translation="MITGYGLLIAFVISIGILLVSIIKFKVNPFLALLITSIITGFMV
                     RMPINEISTTISTGFGNTLGSIGIVIGLGIIFGNILSESRATESIAKGLLAKTGEKNS
                     ALAVTTAGFLISIPVFMDAAFVIMMPIIKYVSRVTKKSLMVFVCALGVGTIVGHALVI
                     PTPGPLAVAANVNANVGSFILYSIIVAFPAALIGGWIYGKRFEKYPAYAIDENDREKN
                     LEQGKDSIKIEDDDSSKVPGFGISMFSLLFPILLILISNVFSMFLEKGSTMSGVLAFI
                     GDKNIAILLGILVAIGFLKKYINKPMGDVVIEAADSAGLILLITGSGGAFGSVINASG
                     IGNFLVDTMSGLSISVVVLGFLLSALLRISQGSATVALVTTSSILGPTILATGMSPVL
                     VGLAICAGGVGFSLPNDSGFWVLSRFSGLSVKDTLNSWTIGGTIAGVVAFIMVLLLSV
                     INGIIPLPGL"
     gene            complement(12400..13305)
                     /gene="garR"
                     /locus_tag="KRO40_002031"
     CDS             complement(12400..13305)
                     /gene="garR"
                     /locus_tag="KRO40_002031"
                     /EC_number="1.1.1.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxy-3-oxopropionate reductase"
                     /protein_id="HBH2092850.1"
                     /translation="MEGYKMKLGFIGLGIMGKPMAKNLLKDGCNLLVYDINKSAVDEL
                     ISCGAKYASVLEMGQECDIVFTILPNGTIVQDILFGIDGLAKTLKEGSIVVDMSSVTP
                     TESILCANKLKDMGLEFIDSPVSGGEPKAIDGTLAFMAGGKEEIYKKVEPFFNIMGSS
                     SILIGDNGSGSVTKLTNQVIVNLTIAAVSEAFVLAAKAGADPEKVYKAIRGGLAGSTI
                     LDAKIPMIMNRDFKPGGKISINLKDIKNVMQTAHNLDVPLPMTSQLLEIMQTLKVHGH
                     LEDDHSGIAQYFEKLAGVEIKKHDN"
     gene            13701..14372
                     /locus_tag="KRO40_002032"
     CDS             13701..14372
                     /locus_tag="KRO40_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2092851.1"
                     /translation="MATFKRLQEQAYDYLKELILSGKMIENEIYSETKLASEIGISRT
                     PIRDALQRLSQDGFIDIIPSKGFRIHQITANEIVEIFQIRSAIEGFCTFLITSQYKEA
                     RAVETISKLKHLLDKQKDILLGDKNLNSFAEYDTLFHTTIVSYAQNTEFDKMFNNYMY
                     RIKKLALDSLSHEGRLETTLKEHTDIFNNIANGCIEDIYRTTLIHMETPKYINLEDFC
                     NNKLF"
     gene            14475..15023
                     /locus_tag="KRO40_002033"
     CDS             14475..15023
                     /locus_tag="KRO40_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092852.1"
                     /translation="MIFLNEDVVTNETIDKDYAIEEVRMACKHFGDLYFYFSKVLFEE
                     FGEDKTSEILRKVLFERSEERAIAMRERAHENGDELIADNIISTTDVPFLGWVPEFEE
                     LHCPYGASWLLRFEENPWFKKFASLYCDVTDTTVAEVFTGDTSHKITKNILWGDKSCE
                     RIYFHDDKVSEGKYTYGNKNCK"
     gene            15285..15593
                     /locus_tag="KRO40_002034"
     CDS             15285..15593
                     /locus_tag="KRO40_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092853.1"
                     /translation="MFNKIYEKKEFIVFQVKKGYVVYNTRKSFEEGHTHLKHFEAAKT
                     AIDLAINKKIPRSKDGYYLTSLIRISDDGYYIDKLSELLYVREQKGKKEKYCNSGYQM
                     "
     gene            complement(15755..17545)
                     /locus_tag="KRO40_002035"
     CDS             complement(15755..17545)
                     /locus_tag="KRO40_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092854.1"
                     /translation="MKKSKGFKKTIGRLLPFVKKYKFSFIIAIICIISAATMNALAPK
                     TEGLIITQLTKDVISIAKGVPGASVNFDYVTKILVILACIYFANAIFTYTSSFLLTNA
                     IQNTMRDLRNEVENKIRRLPISYFDSNSFGDVLSRISNDVDTISNALQQSFMQIVNSI
                     LVIILALSMMFTINIYMALIALFIIPISYFVSKFVVKKSQSRFSLQQNALGKLNGKVQ
                     EMYTGFNEIKLYGKEEDSIKEFKKVNQELCENGFKAQFISSMMNPMVSLVTYFGIAAV
                     AVVGSIYAVSGGITVGNLQAFVRYIWQINQPLSQMTQLSTVIQSSFAAIERVFEILDE
                     EEEIPDVENPVKIENVKGNVTFEHVNFGYGENSTLIEDLNAEVKSGQMVAIVGPTGAG
                     KTTLINLLMRFYDVKKGAIKIDGVDIRDMKRKDLRSMFGMVLQDTWLFNGTIFENIEY
                     GRFGATKEEIIQAAKVANVHHFITTLPDGYNMFLNEEASNISLGEKQLLTIARAFISD
                     PSILILDEATSSVDTRLELMLQKAMRNLMNGRTSFVIAHRLSTIRNADLILVMNNGSI
                     IEQGNHDELMEKGGFYEKLYNSQFADKESE"
     gene            complement(17545..19272)
                     /locus_tag="KRO40_002036"
     CDS             complement(17545..19272)
                     /locus_tag="KRO40_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003496244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092855.1"
                     /translation="MKLILSYLKNYKLLIVLNILAIFSFALVELGIPTIIAKIIDNGI
                     ANQNIAYIKQMGIVIVIISIIGVVGSILLGYCSAKVSTSVTRDIRNDIFEKSQEFSHT
                     EYNKFGISSMITRTTNDAFQIQQFVNILLRTALLTPVMFIISIIMTIRTSVELSIVLA
                     ISVPFIIIGVAIIAKVSQAISSKQQKGLDKLNLISRENLTGIRVIRAFGNDDYETERF
                     EKTNTYYANVSKKLFKLMSITQPAFFLLLNIAVLAVFWISSEKINIGELQVGQLVAFL
                     EYLFHAMFSIMLFSMVFIMYPRAEVSANRIKELLNEEPLIKNPENGIKDTENKGIIEF
                     DNVTFTYPDGEASVLKDISFTAKTGETVAFIGSTGSGKSTLINLIPRFYDVTEGSIKI
                     NGVDIREYDLKALRKKIGFIPQKSLLFTGSIANNIRFGKHKAGESELEYSAKVAQAYE
                     FISKKPRKFDELISEGGANVSGGQKQRLSIARAIIRRPEIYIFDDSFSALDFKTDAIL
                     RAKLKKETKDAIVLIVAQRISSIIDADKIIVLNEGQVVGMGTHKELLKNCEIYYEIAT
                     SQLKKEELE"
     gene            complement(19517..19783)
                     /locus_tag="KRO40_002037"
     CDS             complement(19517..19783)
                     /locus_tag="KRO40_002037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase family protein"
                     /protein_id="HBH2092856.1"
                     /translation="MNLEPKKLIEQIGKEKDKKDIWIVGGGDIVKLFMKDNLIDDYYI
                     YILPIILGRGISLFKSGIDKTNLNFKKASNIGELVKLEYSKKQK"
     gene            20081..21193
                     /locus_tag="KRO40_002038"
     CDS             20081..21193
                     /locus_tag="KRO40_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBH2092857.1"
                     /translation="MKISEVATPNFLLDLDQLEKNIDKIQQICTNNNKQLWPMLKTHK
                     STYIARLQKNAGASGFLVGTLDEGEALIKAGFEDIMLAYPYMGEVNINRIVTMASKIN
                     LICATDNIECAKAYSEAFSKSKIECKLLIIVDCGLHRFGVEPEKVVELATEISKLENI
                     KIVGISSHPGQVYGCSSPEGVPDVCVQEDSSMEKAYKALTDNGFNIEIVASGSTPTVE
                     SEAASKTITAVRPGNYVYYDAIQIGLGCATEDMCALTVVCTVISKNSSGYYLIDCGSK
                     CLGLDKGAHGNSSIVGYGRVCGHPELTIDSLSEEVGKIKVNGETDIKIGDRIRIIPNH
                     SCSTANLTSNLLGFRGDTIEKVIEVDIRENSKQIIL"
     gene            complement(21557..22066)
                     /locus_tag="KRO40_002039"
     CDS             complement(21557..22066)
                     /locus_tag="KRO40_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjiG family protein"
                     /protein_id="HBH2092858.1"
                     /translation="MSQQNTGNAIVNSKPKKTAVEIFMGGAKKGFYIGVEQILPAMIM
                     GYVIVQFLQLTGLVDILGNIFGPVMGIFGLPGESVVVLIAAFFAKAAGAATAANLFAQ
                     GLITAPQATILIMPCMLMGTLVGHYARIVLVANASTKYRMLLLAVPIFDAIVGMLIVR
                     VLLTVMGLM"
     gene            complement(22068..22715)
                     /locus_tag="KRO40_002040"
     CDS             complement(22068..22715)
                     /locus_tag="KRO40_002040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092859.1"
                     /translation="MDVTAGDNKVTWKGYLSLFVLIVLFSGVFKDSQGFLKALDFANL
                     TGSFGTIADGVDFMGKGGTGAKDGFLFALTLIPTVCFAVGLIDVVESMGGMKAASKIF
                     NPLLRPLLGIPGIAGIAFVSSFTSSDVASIMTKELFESGEITDDERTIFVAYQYAGSA
                     VILNTINTQAPLLPIALLALGPIILIEIFCKILGANLVRLIIGVRNKKNKAKEAV"
     gene            complement(22729..23901)
                     /locus_tag="KRO40_002041"
     CDS             complement(22729..23901)
                     /locus_tag="KRO40_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2092860.1"
                     /translation="MNTYLNEISKFVDENREEIVSLWKEIVNMESYTHCKESVNKLAK
                     RLKFEFEKEGLDCELVDVGDNGSTLIGTLGSNIDKKPIIFSGHMDTVFETGTFGENPF
                     KIIEGKAYGPGVLDMKGGIIISLYVIKALNKIGYKERPIKIVFSGDEEIGHKDSTGAD
                     VILREAKGGLCAFNMETGLVDNSLCVGRKGRIGCNIHVKGVETHAGNDFEGGRNAIEE
                     MANKILRIQKLTNLDVGTTVSVSVIKGGRVENSIPEDCSIKVDLRFEKVEEMENVKEQ
                     VREICKETYIEGTSTEVNFISEMMPFETTEDVMRFHTFVNEVSKENGFGELNAKRLGG
                     SSDASYLTIANVPTICSFGVRGEWNHTSREYAVVNSMFERVKLISTVILNLDKFEV"
     gene            24170..25546
                     /locus_tag="KRO40_002042"
     CDS             24170..25546
                     /locus_tag="KRO40_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092861.1"
                     /translation="MKYKIGFLTTSYFMSDKFKQALKELNDTCEITFIELKGENPFNN
                     LPNIYYEQVDNFDGFVCSGIVPYSELIINIKDIKVPLNFLKLDERDFYKYLFKLLNSQ
                     KDIDFTKSFMDFLREDNNYYDIYSLIDSNKCPYTIKDFNIPQPVYDFKKLNDKLLEIH
                     LDLLRDNKINLSFTRNYIISCELNKLGYDCIYMVPSTESILNTFKSLVNEITLQNLDK
                     NKSATCIVTVNSSEYINEDLIFKNDEIQNQIYNTILNSLSRHGFYGVQVKKNDMKIEI
                     HTTKEMLNNMTNNYTDFFISEDLKEIKYSLNIGWGIGNTNIHAEQNARQANGKSASLN
                     GNCTFIVNDTNDTIGPLYSNKNSNNIEDSSIANKVASFIPLSNTNVSKIMCMINDRNS
                     NNVSAEILADYMNITLRSANRILSILYKAGIATIVNTKLDNQRGRPKKIYKVDFLSFL
                     NKMQKLNS"
BASE COUNT         8888 a         4447 c         3077 g         9837 t
ORIGIN      
        1 aaattagagt ttaaaattaa aaattattct aatacatgta attgataaaa aataaaatat
       61 aagagtagct actttaaaat aaatgctctt acatgattag atatttttgc ataattaaac
      121 gataagaaat caaatttact tctacataaa tagaatatat atttttatat aataattgaa
      181 aataaaagag gatacctcat aatgataaaa gaatcacttt gagataccct cttacaaaca
      241 actaaatcaa taattttcta tctttcacac tcttgatttg caactgtaca agaagtttta
      301 caagctgatt gacaagaagt ttgacactct ccacatccac cttttgcagc actttgcttt
      361 aaagtagctt gagataaagt ttttacatgt ttattttcca ttttcaacgc ctccatttct
      421 aattgtttcc tattgattat atcataaaac tactttaata taaactctat ttaaagttga
      481 cacccaatac gcctccaatg cctcctgctg ctgatattag caataactta taaatcatcc
      541 ctatttcaaa tacaaacttt tcttgtgcta aaaacacagt caaaaaaata catactatgt
      601 acaaaagtcc tactaaaagc ccatacataa gtcctttttc tttcatgtgt tttgaagtgt
      661 aaaaccctcc tatagctgca gaaatagtag ttataaatga tgagaccata gttatattat
      721 ctccaccaat atctgtaaat gtcaaaaata agttatacac taataaaaca gccaaagtta
      781 ttatatatgc atatcctaga cctttaaaaa tataattaga ttttcccata aaaaaacctc
      841 ctctcaaatt aatatatatt cgagaaaagg cttttaaatt actaatttag tcttcttcta
      901 tttcttcttt tttagattta acagttccta tagcccattt ttcaaatgga actttagttc
      961 tatttggtcc taattctaat attacaacat catcttcaac tttagctaca ttagctacta
     1021 ttccacctat tgtaatgacc ttgtctccta cacttaggct gcttctcatt tcttttaatt
     1081 gtttgtcttt tttcttttga ggtctaatca ttaggaaata aaagattgcg attactacta
     1141 cccatagacc tatactcata attatttgtt gctgtggcat taatttttca ctcctttgta
     1201 aattatactc ttttgtaaat cataataaat gtttatataa caatttactt tctctatctt
     1261 tgagtactat tgaatattat atattaaaat gattataatt aatagtgcaa aacctatatt
     1321 tcatatccat attttgcaaa aaattcattt ctaaaatcaa gtaatctatc ttccattatc
     1381 gcttgtctta tttgtttcat taaatttaat aaaaagtgaa gattatgagt agttattaat
     1441 cttgcaccca gtatttcatt tgcttttata aggtgtctta tataagctct tgaatagttt
     1501 ttacaagcat aacaatcaca ttcagggtca agtggagtaa agtcttcagc ataagttgca
     1561 tttctaacta ctactttacc ttggctagtc attgcagttc catttctagc gatacgagta
     1621 ggtagaacac aatcaaacat gtctactcct cttataacac cttctactaa gtcatctgga
     1681 ctaccaactc ccattaggta tcttggttta tcctttggca taagtggagt tgtatgctct
     1741 aacacgtcat acataagtgg ttttggttct ccaacactaa gtccaccaat agcatatcct
     1801 ggtaaatcaa tattagttat ttctttcgct gattgttccc ttaagtcttt atacatccca
     1861 ccttgtatta taccaaataa agcttgcttg tcggtattat tatgggcatc tttacatctt
     1921 tttaaccatc ttgttgttct ttctaaagaa ttttttacat attctctatc tgatgggtat
     1981 ggtgcacact catcaaatgc catcattatg tctgaaccca atgcattttg tatttccata
     2041 gctttttctg gagttagaaa atgttttgaa ccatctaagt gtgacctaaa ttctacacct
     2101 tcttctttta tctttcttaa aggccctaga ctaaatacct ggaaccctcc actatctgta
     2161 agtattggtt tatcccaatt cataaactta tgaagaccac cagctctttt tataagttca
     2221 tgacctggtc tcatatataa atggtatgtg ttactaagta ttatttgtga accaatctct
     2281 tttaattctt ctggtgtcat agattttaca gttgcttgag ttccaactgg catgaatatt
     2341 ggtgtttcaa taatcccatg tggagtgtgt aatcttccta accttgcacc actctgctta
     2401 caagtcttta tcaattcgta tcttactgcg tacataaagt tctccttaat catatttatt
     2461 tctcattatt tcttaagata tatttgtaat aagctattca tataatttat tgtctaaata
     2521 gatttatctt cgtcttcttt gttctgttgt tccttaattg cttcttcatc atgaatactc
     2581 attatattaa gagcactctt gtcttttgtt actaaaaact tttttatagc aaatagtcct
     2641 gctatagcta taactcctat taaaacatct atcatacctt catttttagg cagtagcaac
     2701 atttttctag caattgcgta aagtaatgcc tcaataaatg ctcctggtat atgaagagat
     2761 agcattacta caagttcaac acctattact aaaagtaata tttgtgctaa aaaatcatta
     2821 agctgactgt attgtactgg attttgaaaa tcaactatat atgctcccca cataagtctt
     2881 agaacatcta tagttcctaa aaatactgct attagaacta ctactgctaa aacacgttca
     2941 aatataaaag caatctttaa tatagggtta ttcttttttt gtttttgtaa actatgcatc
     3001 cattacctcc ctactttata atcatagcat ctccaaaact gaagaatcta tatctttctt
     3061 ttactgcctc attatatgca tttaaaacat tatcctttcc acaaatagca cttactaaca
     3121 ttattagtgt agactctggt aagtgaaaat tagtaataag tttatctaaa actttaaatt
     3181 tataacctgg atatataaat atttctgtcc atccactagt ttctttcatc tttccatact
     3241 cattacaagc tgattctata gttctacaac tggtagtacc aacacatatt acattttttc
     3301 cattttcctt tgctctattt attttgtcag ctgcttcttg gctaaccata taatattctg
     3361 aatgcatctt gtgatttaaa acatcctcta cttttactgg tctaaaagtt cctaagccaa
     3421 catgtagagt tacaaaggct atatctacac ctttttcttt tattttattt aacaattctt
     3481 ctgtaaaatg taatcctgct gtaggtgctg ctgctgaacc attatgcttt gaataaacag
     3541 tctggtatct ttctttttca tctagtctag cagtgatata tggaggtagt ggcatatttc
     3601 caagttcatc caatatttct tcaaaaattc catcataatg gaattttata attcttgaac
     3661 cttcatctga taaatctaca acttctccaa ttagctttcc atttccaaaa gaaaatttag
     3721 tccctacttt tgctcttttt cctggtttta ctaaagcctg ccaagtatct tcctctgttc
     3781 tttttaataa taaaaactct attttacctc cagtttcaag cttctctcct attaatctag
     3841 ctggtataac tctagtatta tttaatacta agcaatctcc tggatttaaa tattctatta
     3901 tatctctaaa tactttatgt tcaatattac ctgtctcttt atctaatacc atcaatcttg
     3961 agctagctct atcttctata ggaacttgag ctataagttc ctgtggtaag tcaaatttaa
     4021 aatcacttgt tttcaatgtt aaacttcctc tcttaaaatt tctccagcta caataatatc
     4081 aaaaaaacaa cttattttcc acaatattac cataatctat caagaaattg ctatttttaa
     4141 cagacaccat atccacaata tatagatatt tttccacgat atacatgtct tatccacaat
     4201 atatagatac aatacacaca atttttatcg tgtttatcca cagtatctac agatataatt
     4261 accattttgt ggatatgttt gaatttttag ccattttaga aatattttaa tttaatgact
     4321 cttttatttt ataaatactc gtataatcta tttttatttt tcattaggat atggaatttt
     4381 taagtgttca tatgctaatg gcatagctac tcttcctcta ggacctctat ttataaatcc
     4441 taattgaagc aaatatggct catatacatc ttctattgta tttctatctt ctccgataga
     4501 agctgccaat gtatctaaac ccactggtcc tcctctaaat ttttctatta tagtcataag
     4561 aagcttctca tctacaaaat cgagacccaa actatcgact cctaaaagtt ccagagcatc
     4621 ttttgccacc ttatcagtta tttttccatc agctctgact tgtgcaaaat ctctaactct
     4681 ttttagtaat ctatttgcta tccttggagt ccctcttgaa cgttttgcaa gttctaatgc
     4741 tccattagac tgtatctctg catctaagat gcttgaagac ctaagtacta tttttgaaag
     4801 ttcatcaact gtataatagt ccaatttaca aataacacca aatctatctc taagtggatt
     4861 tgtaagcata ccagctcttg tagtagctcc aataagtgta aatttaggaa ggtcaagtct
     4921 tatgcttcta gcagatggcc ctttccctat tattatatct aggcaaaaat cctccattgc
     4981 tggatataaa acttcttcaa cacttctatt gattctatga atctcatcta taaataaaac
     5041 atcattttca tttaaattcg taagtatggc tgccaaatct ccagctcttt ctattgcggg
     5101 tcctgacgta attcttaaat ttacccccat ctcatttgct attatacttg ctagtgtagt
     5161 ttttccaaga cctggtggtc catataaaag cacatggtct aactgctcat ttctcgattt
     5221 agctgcttct ataaatatac taagttgttc tttggatttt tcttgaccca aataatcttc
     5281 taaagttttt ggtcttaaac tattttctat atctatatct tccatcttca ttgtagaagt
     5341 tattatccta ttttcatctt caaaaccttg catttatacc cctcctctca tacttttgaa
     5401 aatctacttt atatattttc aaatttacat aaactcctta aatattgttt taaaatccaa
     5461 atattataaa atccaaatac tatttcaagg atttactcat tatatatgta agtgctttct
     5521 ttataatagc ttctgtattc ataccatctt ttttacattt ttgaactgcc tcttttgatt
     5581 ccgacaaagt atagcctaaa gctacaagtg catctacaga ctcatcttgt gatatcaagg
     5641 taggtttttg tgataataac gttggttcaa actctatgtt atttttgtct accttatcct
     5701 taagctctaa gacgattctt tctgctgtct ttttaccaac accaggagct ttggataatt
     5761 ttccaatgtc ttcacttaaa atatatgctc ctaactgtgc tggtgatgca aatgatagta
     5821 ttgaaagcgc cactttaggt cctattttag atacagatgt tagtaattca aacatcttaa
     5881 gttcttccct acttacaaaa ccacaaagac tcatatcatc ttctcttaca attaatttag
     5941 tatatatttt tgtggcttct cccacttgta aattcattat tgtattggat gatacattta
     6001 ttttatatcc tatcccatta ttttcaacaa ctatactgtc tatataaatt tcttctactg
     6061 taccttttat ataactatac atacttacca cctatattct ttagagtttt ttcaagtttg
     6121 tttgaatgag catggcaaat agccacagct aaagcatctg caacatcatc tggttttgga
     6181 acttttttta gacttaaaaa tgaagttacc atctgttgaa cttgtgcctt atctgctctc
     6241 ccatatccaa ctacaccttg ttttacttga agtggagtgt attcatatac aggcttccca
     6301 ttatgagcac atgcaagcat agtaacacct ctagcttgtg caactgttat agctgttttt
     6361 acattcttgt taaagaataa ttcttccatt ccaacttcat ctatattgta attctttact
     6421 attgtatcaa ttcctttata cacaagttcc aatcttctcg atatattcat atgggcaggt
     6481 gttgtaactg ctccataatc gattacttta aacttgctat ttttgtattc aattatacca
     6541 tatccaacta tggctatacc tgggtcaatc cccaatatta tcatttttta aaattccccc
     6601 taaaaataaa agaaatacca aaatgtattt ctcataaaaa cttatgttct aaatcattat
     6661 atcataaata atattaacaa atcataaaat gctctatgta aaatataaaa tcaaataaaa
     6721 aagttatatc aaagcaagat tttacctcaa tataactttt atatttatta caaataaatt
     6781 attgtatttt tataggaatt aaatgtgact acaattttaa tactaatcta tttaatatta
     6841 aattatttat tattaattta cttagtattt aacttactta gtatttaact taaaataata
     6901 ttaatttact attaacttgc aaagtcttct aatcttgaat aggcctcttc ttcagtatcc
     6961 ataactacac cttttttgat ttcatcttga actgttttag gaagtgaatc tactcttatt
     7021 tttgtttttt ctactaatgt tttacttccg ctatcatcat atttatatag tgctatattt
     7081 ccattatcat tttcaatagt atatttacct tttatagtaa catccattgc ttgtacatct
     7141 ttattatcac tatatttaga ttctaccaat atgatttcat ttttatccat actctttatt
     7201 tttttagttg gatattcttt tttaaaatat gatactattt ctgacttcgt cttatctaat
     7261 aatgactctg gaactattcc tgccattgta agtgttctct tatagttagt ttcattttcg
     7321 ccttcacttt gaagccaaac ttcacaattt ttatttaatc caaaagcttc ttttgacttt
     7381 tcattcatat tcgcactagt acttacaact tcaccagttt gaactccatt gtgttttaat
     7441 cttgtcccta tataaactcc gctacttaat acaaatactc caaccagtat taaggcagat
     7501 attttccaag gaaataattc ttttttcttc ttttcaaaca ttgattacgc ctcctttttc
     7561 tattattttc tccaagctgt aagtttttat acaatttagg taaattttag aagaaaatat
     7621 atttatattt caaattactc taagaataga tattttctaa aaggtagttt tctcttaatg
     7681 gttatattct tgtaattata tggacataat ttataataaa taatcgttta ggaggtaata
     7741 actttggaaa gaataaactg taatgtaatt aactgttcac ataacaacag ccatatatgt
     7801 tatgcagata aaatttttat aaatggtgaa aaagctcaca atgacagaca tacttgttgt
     7861 agttcatttt tagatgaatc tatttatagt aatttatcta gcaacgttaa taatagaaat
     7921 tgtgaggaat tagtttgtac tgtaaaaaat tgtaaataca acaaagatgg tagcttatgt
     7981 acacttgata atatattggt tgctcctgaa actgatagag taaaccttta tattgaaaca
     8041 tgttgctcta gtttcgaatg taaatagtca tagtataaat ataagggtgt caaatgtaat
     8101 taaactaaca tagtgtagag tatctacaac tattagtttg attatacttg acacccttat
     8161 ttattttaaa taaaatttca ttattataac catgtttata atgttctaac tgtaattaaa
     8221 tttgataaat ttctataaat tggtataatc aatatgtaaa ttgaatttag taaattaatc
     8281 aaaaaaataa aatatcgagt atatagtgtt atactaacta gaaatgaggt gcttatgagt
     8341 acattttata ttcaatttct ttattttgta atttatagct ttataggatg gtgttgtgaa
     8401 actacatatt gttcagtttt acaaaaacaa tttgtaaata gaggtttttt aaatggtcca
     8461 ttttgcccta tatatggatt tggagcatta gcaatagttg ctaccttgac tccttttgta
     8521 cacaatattc ctttgttatt tttgtttagt ataattataa ctagcataat ggagtattgt
     8581 acgagcttta ttttagaaaa aatatttaat atgacttggt gggattattc taaacataaa
     8641 tttaatattc atggaagagt ttgtctggaa aactcactta tgtttggtgt attatcattg
     8701 attgtaatgc ttatagtaca tcctattgtg gttgacttta ttaactctat ctccaaaaat
     8761 gtgctattta tatttgctat atctatagaa atttattttg ttttagattt agttatcaca
     8821 gtccatacaa ttttacaatt aaatggtaag ttaaaacaaa tcaatcttat aattaaggaa
     8881 ttaaaagata agaaagaata ctacaaactt attacacaag aaactataga aaacaaactt
     8941 gaatctttag ttgaaaatag actggatact ttggaagata gatttgaaat acttaaggaa
     9001 aaagaaaact atcgctatgc taaaaatcgt attgatgagc taaaaaataa acttaatact
     9061 ttgctgtcta accacaaatt acttcataga cgtataatca aagcattccc caacataagc
     9121 tctaataagc atacagatat tttaaataaa atcaaagaaa atattaaatc aattaaaaaa
     9181 gataaataat aaaataaaca cataagttaa ataataaaaa tactaataca taagattaag
     9241 gtttagaata ttttttgtaa aatactctaa accctaatta atatactatt atttttaatc
     9301 ttaatttata attttagttt attttacttt taacacagta aatttaagcg tttaaacttc
     9361 aatacactaa tatactaccc catcaatatc tcaactgatt ctctaagtgt gctaatctct
     9421 cccacatttc cagggaaaat tatatatggc atattaggaa atttgctttc tttgcctgtc
     9481 atccatactg gtataccagg ttttatctgt cccattactg tagctttttt tactcttagt
     9541 gctttagtac caacatcact agaagtaatt ccacccttag ctataataaa atttggcctt
     9601 acattaagca taccaattat actggtaact gcatctgata tttctacaga aatcataagc
     9661 tgtttatctt tatcatttgt atccaagtca aaacgctctc ttctagtata aacagcaaca
     9721 gttttacccc tgcttatttt ttcctctaca acttttataa ctctttttac ctcatttttt
     9781 agaccatttt cttgaagaac taaatgttga ttaaattcta taaattctat tggatattta
     9841 caatttttaa gttcttctaa ctgttgggta gtcttattca catgtgaacc aacaagtata
     9901 attcctccat tggtattacc ttttgatact aattcatcct tagtaagcag ttccttatca
     9961 ctcactccgc caagtacttt tgttatggca gcagcgcttc taaacataaa ttccttacca
    10021 ctatttactg ctcgtataaa cgcaattgta aataccttta catctacata gtcggttgca
    10081 tttacaataa ttttattgaa tccttcagct tttttaagtt tttctgttat agcttcaata
    10141 tttagctctc taagttcttt tgacgaaata tatatcatat cactagattt gtactttcct
    10201 tttgtctttt cttcacacca ctcacctata tcagatgatt tatatccaaa agatttatct
    10261 tttgcaaatt cagtcattcc tgctggtaca agtatttctc cttctttaac ataatgtaca
    10321 ttatctatag taaacctacc accttcttta aaaaatggca ttattatttc accctgaaat
    10381 aacttccccg ataatctctc tacttcgctt tttaataaat tagtttcaag aggataatgt
    10441 cctctcatag tagaatcact acgacttatg attataaaat ccttattaac tttctttgat
    10501 acatccacaa tattctttga aatttcttta tgtgcttttg tagtttgagc aacagtaaat
    10561 ccccttgaat tggtaagtat aaaaaacata ctatttttct cattaaaacc ttgttccata
    10621 ctatccttat cccaatcagt ataaacagaa atatcatgaa ctgtttgtac acctgttggg
    10681 tcatcatcta atacaacaat ttttctatct aaatgcttaa gctcatctgc aagaagttta
    10741 tttaatctgt cctcatctac ttgtttaaaa gtattaagta tatctatgct aattggtttt
    10801 acttctctca tttaaaacgc ccctttatgt aatttgtata gtctaaatgt aatttatatg
    10861 atataaacaa tagtttgtta tttatagacc tggaagtggt ataattccat ttataacact
    10921 aagcaataaa accattataa atgctacaac tccagcaatg gttcctccaa ttgtccaaga
    10981 gtttaaagta tctttaactg ataatccact aaatcttgaa agtacccaga atccagaatc
    11041 atttggaagg gagaaaccaa ctcctccagc acatatagca agccctacta aaactggtga
    11101 cattccagtt gccaaaattg taggtcctaa aattgatgat gttgttacta aggctacagt
    11161 agcagaacct tgagaaattc taagcaaggc acttaataag aatccaagca ctacaactga
    11221 tatactaaga ccagacatag tatcaactaa gaagttacct ataccacttg catttataac
    11281 actgccaaac gcaccacctg aacctgttat caataatatt agccctgctg aatcagcagc
    11341 ttcaataact acatctccca taggtttatt tatgtatttc tttaaaaatc ctattgccac
    11401 caatattcca agaagtattg ctatgttttt atctcctata aatgcaagta ctccactcat
    11461 tgtagaacct ttttctaaga acatactaaa tacatttgat ataagtataa gaagtattgg
    11521 gaacaataaa gaaaacatag aaattccaaa acctggtact ttagaagaat catcatcttc
    11581 aatttttatg ctatcttttc cctgctctaa atttttttct ctatcattct catcaatagc
    11641 ataagctgga tatttttcaa aacgttttcc ataaatccat ccacctataa gagctgctgg
    11701 aaaagcaaca attatagaat aaagtataaa actacctaca tttgcattta catttgctgc
    11761 aactgctaaa ggtcctggtg taggtattac aagtgcatga cctactatag tcccaactcc
    11821 taatgcacat acaaaaacca ttagagattt cttagttact ctcgaaacat acttaattat
    11881 aggcatcatt ataacaaaag ctgcatccat aaaaactgga attgaaatta aaaaacctgc
    11941 tgtagttact gctaaagcac tgtttttttc tccagtctta gctaacaacc cctttgcaat
    12001 agattctgtt gctcttgatt ctgaaagaat atttccaaat attattccaa gtccaattac
    12061 aatacctata ctacctaatg tatttccaaa tccagtcgat attgtggttg atatttcatt
    12121 tataggcatt ctaaccataa agcctgtaat tatagatgtt atcagtaatg ctaaaaacgg
    12181 atttacttta aatttaataa tcgatacaag taaaattcct atagatataa caaatgctat
    12241 caaaagtcca tatcctgtaa tcataatctt taccccttta tcattctact ttattattta
    12301 tcaattttat ttttctttta ctatgataac ttaacctcgc tgtatttata taatctaatc
    12361 ctaataatat gtatttaatt atattgatat atttaaatat taattatcgt gtttttttat
    12421 ttcaacacct gccaactttt caaaatactg tgctattcca ctatggtcat cttccaaatg
    12481 tccatgtact tttaatgtct gcataatttc taataattga cttgtcatag gtagcggtac
    12541 atctaaattg tgtgctgttt gcattacatt cttaatatct ttcaaattaa tagatatttt
    12601 tccacctggt ttaaaatcac gattcataat cattggtatc ttcgcatcca atattgtact
    12661 accagctagg cctcctctta ttgccttata tactttttct gggtctgcac ctgcttttgc
    12721 tgcaagtaca aatgcctcag aaactgctgc tatcgtcaaa ttaactatta cttggtttgt
    12781 aagttttgta acacttccac taccattatc tccaattaaa atagatgagc ttcccattat
    12841 attaaaaaat ggctctactt tcttataaat ttcttcctta ccaccagcca taaaagcaag
    12901 tgtaccatca atcgcttttg gctcccctcc acttactggt gagtctataa attctaagcc
    12961 catatctttt aatttatttg cacacaatat tgattctgta ggagtaactg aactcatatc
    13021 gactactata cttccttctt ttaaagtttt tgccaatcca tcaatcccaa acaatatatc
    13081 ctgcacaata gttccatttg gaaggattgt aaatacaata tcacattctt gacccatttc
    13141 taaaacactt gcgtattttg ctccacatga tataagttca tccacagcag atttattaat
    13201 gtcatacacc aaaagattac atccatcttt taataaattt tttgccattg gctttcccat
    13261 tattcctaat ccaataaatc ccaatttcat tttataaccc tccatatctt cacatttttg
    13321 aaaacgtttt ttatgtttta gagtatacta cataccagta taccggtcaa tataaaatat
    13381 aaaagtattt attttaacaa taaatagtaa tttttaaagt catttattat atttagtcat
    13441 cctatataag ttttaataca tactattgtt ttcaaatata atatactact tttacagttt
    13501 tgtattttaa ctaatttcaa ttagttttaa ttaatctgcc tttaatgtta atcatgcttc
    13561 acacttcaat aattttttat attttttaat cttatctgca atttaaattg caaaagattg
    13621 accttatttt cactatgttg tatgcttaaa attatataag tttttgtatt tttatattgt
    13681 ttaggggggt attattaagt atggctacat ttaaaagatt acaagaacaa gcatatgact
    13741 acttaaaaga attgatacta tctggaaaaa tgatagaaaa tgaaatatat tctgaaacaa
    13801 aacttgctag tgaaataggt atttctagaa cacctataag agatgctctt caaagactta
    13861 gtcaagatgg atttatagat ataatcccaa gcaaaggatt tagaatccat caaattacag
    13921 caaatgaaat tgtagagata ttccaaatac gctctgcaat agaaggattt tgtacttttt
    13981 taattacaag tcaatacaaa gaagctagag cagtagaaac tataagtaaa ttaaaacatc
    14041 ttttagataa acaaaaagat attttattag gtgataaaaa tttaaactca tttgcagaat
    14101 atgatacatt atttcacaca actatagttt catatgctca aaatactgaa tttgacaaaa
    14161 tgtttaacaa ttatatgtac agaataaaaa aattagctct cgattcattg tcacatgaag
    14221 gaaggcttga aacaacatta aaagagcaca cagatatttt taataatatt gcaaatggat
    14281 gtattgaaga tatttacaga actactctca ttcatatgga aactcctaaa tacattaatt
    14341 tagaagattt ttgtaacaat aagttatttt agcattatac cttcatttat taaaaatata
    14401 tctatctcaa attaatttcc taatttataa aaaatattct ataattatat tgtaactaat
    14461 acttattcta aggagtgatt tttttgaacg aagatgttgt aactaatgaa actattgaca
    14521 aagattatgc tattgaagaa gttcgtatgg catgcaaaca ttttggtgat ttatattttt
    14581 atttttccaa agtgttattt gaagagtttg gtgaagataa aactagcgaa atattaagaa
    14641 aagttttatt tgaaaggtct gaagaaagag ctattgctat gagagagaga gctcatgaaa
    14701 atggagatga attaatcgca gacaatatta ttagcacaac tgatgttcca tttctaggat
    14761 gggttcctga atttgaagag ttacattgcc cctatggagc ttcctggctt ttaagatttg
    14821 aggaaaatcc ttggtttaaa aaatttgctt ctctttactg tgatgttaca gatactactg
    14881 tagctgaagt atttacagga gatacttccc ataaaataac aaaaaacatt ctatggggag
    14941 ataaaagttg tgaaagaata tatttccatg atgacaaggt atctgaaggt aaatatactt
    15001 atggaaataa aaactgtaaa taaataattt aaattttcta tattcatata ctatattttg
    15061 tactttttca tataaatatt ataactagtc ttttatttta cttttgttta acctaaagat
    15121 aatttacttt taatctatat gaattatcat ataaataatc agaaagttat ctttataaat
    15181 tatagtttta gatttataat ttataaaata tttatgttct ttgtaaaatt ttttagaagc
    15241 ttctaatgtt atgctataaa actatcttga gaagggctga ttgaatgttt aataaaatat
    15301 atgaaaagaa agaatttata gtttttcaag ttaaaaaagg ttatgtagtt tataatacta
    15361 gaaagagttt tgaagaaggt catacacatt taaagcattt tgaagcagca aagacagcta
    15421 ttgatttagc aataaataaa aagattccta gaagcaaaga tggatattat ctgactagtt
    15481 taattcgcat aagtgatgat ggttattaca ttgataagtt aagcgaattg ttatatgtta
    15541 gagaacaaaa aggtaaaaaa gaaaagtact gtaattctgg ttatcagatg taacaagact
    15601 agttgtgaat tataagtacc aatcataaat acctttagtc ttaaaatcaa agagtatcag
    15661 taaatctata aaaaaacaac ttactgatac tctttttaat tatatgatta atatttgaat
    15721 ttgatacaaa attttataca aaagtttatg ttatctattc tgattctttg tctgcaaatt
    15781 ggctattata aagcttctca taaaatccac ccttttccat taattcatca tgattcccct
    15841 gctctataat acttccatta ttcataacta aaatcaagtc agcattgcga attgtagaaa
    15901 gtctatgtgc tataacaaaa ctagttctac cattcataag atttctcatt gctttttgaa
    15961 gcataagttc cagcctagta tcaacagaac tcgtagcttc atcaagtatc aatattgaag
    16021 ggtctgatat aaaagctcta gctatggtta aaagctgttt ttcccctaga gatatattag
    16081 atgcttcttc atttaaaaac atattgtatc catctggaag agtggttata aagtgatgaa
    16141 catttgctac ttttgctgct tgtataattt cttctttagt agccccaaat ctaccatatt
    16201 ctatattttc aaaaatggtt ccattaaata accatgtatc ttgaagcacc ataccaaaca
    16261 ttgaacgcaa atctttacgt ttcatatctc ttatatctac tccatcaatt ttaatagcac
    16321 ctttctttac atcataaaac ctcatcaata agtttattaa tgttgtttta cctgctccag
    16381 taggtccaac aatagctacc atctgaccac tttttacttc tgcatttaaa tcttctatta
    16441 aagttgaatt ttctccatat ccaaaattaa catgctcaaa tgtaacattt ccttttacat
    16501 tttctatctt aactggattt tcaacatcag gtatttcctc ttcttcgtct aaaatttcaa
    16561 atacacgttc tatagctgca aaagaagatt gtattactgt agataactga gtcatttgtg
    16621 aaagtggctg atttatctgc catatataac gcacaaatgc ttgtaaattt cctactgtta
    16681 ttcctccact tactgcatat atagaaccga caactgccac agctgcaatt ccaaagtaag
    16741 ttactaatga aaccatagga ttcatcatac ttgatataaa ttgtgcctta aatccatttt
    16801 cacaaagttc ttgatttact tttttaaatt cttttataga atcttcttct ttaccatata
    16861 gttttatttc attaaatcca gtatacattt cttgtacttt tccatttaat tttccaagag
    16921 cattttgttg caatgaaaat ctactttgag atttttttac tacaaattta gatacaaaat
    16981 aactaattgg aattataaaa agagctataa gagccatata tatattaatt gtaaacatca
    17041 ttgaaagagc caaaattatg actaagattg agtttacaat ttgcataaaa ctctgttgca
    17101 atgcatttga tattgtatct acatcatttg atatacgact taatacatct ccaaaactat
    17161 tactatcaaa ataactaata ggcaatcttc ttattttatt ttcgacttca tttcttaaat
    17221 ctctcattgt gttttgaata gcattcgtaa gtagaaaact tgaagtatac gtaaaaattg
    17281 cattggcaaa atatatacat gctaaaatca ccaatatttt tgttacataa tcaaaattta
    17341 cggaagcccc tggtactcct tttgcgatac taattacatc tttagtcaat tgtgttatta
    17401 tcaatccttc agttttaggt gcaagtgcat tcatagtagc tgctgaaatt atacatataa
    17461 tagctataat aaaggaaaat ttatatttct ttacaaatgg aagaagtcta ccaattgttt
    17521 tcttaaaacc tttagacttt ttcattattc taattcctcc ttttttaact gagatgttgc
    17581 aatttcatag tatatttcac agttttttaa taattcttta tgagttccca ttcctacaac
    17641 ttgtccttca ttgagtacta taatcttatc agcatcaata atagaactaa ttctctgggc
    17701 aacaatcaat acaattgcat cttttgtttc cttcttcaat ttagcacgaa gtattgcatc
    17761 agttttaaag tcaagtgcag aaaaactgtc atcaaaaatg tatatttcag gtcttcttat
    17821 aatagccctt gcaatagaaa gtctttgttt ttgacctcct gatacatttg ctccaccttc
    17881 actaatcaat tcatcaaact ttctaggttt ttttgatata aactcatatg cttgtgcaac
    17941 ttttgcggaa tattctaatt ctgactctcc tgccttatgt ttcccaaatc taatattatt
    18001 tgctatgcta ccagtaaaaa gcagtgattt ttgaggtatg aatcctatct tttttcttaa
    18061 agcttttaaa tcatattctc ttatatctac tccatttatc ttaatgctac cttctgttac
    18121 atcataaaat ctaggtatca agttaattag agtacttttc ccactaccag tacttcctat
    18181 aaaagcgact gtttcacctg tttttgcagt aaatgaaata tccttaagta cagaagcttc
    18241 tccatctgga taggtaaaag ttacattatc aaattctatg atacccttat tttcagtatc
    18301 cttaattcca ttttcaggat tttttatcaa tggttcttca tttaatagtt cttttattct
    18361 atttgcagat acctctgctc ttggatacat aataaatacc attgaaaaaa gcataattga
    18421 aaacatggca tggaaaagat attccaaaaa tgcaaccaac tgtccaactt gaagctctcc
    18481 aatatttatc ttctcacttg aaatccaaaa tacagccaaa acagctatat ttaacagtaa
    18541 aaagaatgct ggttgagtaa ttgacataag cttaaatagt ttcttagaaa cattagcata
    18601 atatgtattt gttttttcaa atcgctctgt ttcataatca tcatttccaa aagctctaat
    18661 tactcttatt ccagttaaat tttctctcga tataaggttt aatttatcta gtcctttttg
    18721 ttgttttgaa gatattgcct gagatacttt tgctattatt gctactccaa taattataaa
    18781 aggtactgat atagccaata ctatagaaag ttccacactg gttctaattg tcattattat
    18841 acttataatg aacataactg gagttaataa ggcagtcctt agtagtatat taacaaattg
    18901 ttgaatttga aatgcatcat tcgttgttct tgtaatcatt gaagaaattc caaatttatt
    18961 gtattcagta tgtgaaaatt cttgtgattt ctcaaatatg tcatttctta tatctctggt
    19021 tacacttgtt gataccttag cagaacaata acccaacaat atactaccta caacccctat
    19081 aatagaaata ataacaatca ctattcccat ttgttttatg taagctatat tctgatttgc
    19141 aataccattg tcaattattt tagctattat agttggaatc cccaactcga ctaatgcaaa
    19201 actaaatata gccagtatgt ttaatactat taataactta taattcttta aataacttaa
    19261 aattaatttc atatttttct cctttcttaa tttttgagat agtgtaatca tgtaataata
    19321 ctaaatttat aaatgcttaa ttttataaaa aaaggagaaa agagttaacg cactctcttc
    19381 tccagcatat tctttttaat acaccctccg acaagtcgct tatatgttaa catatttgac
    19441 aagtaatgtc aattcatata gccaaaagtc ttttaaatgc ttcgtttcat aacattgtaa
    19501 caaattggca tgtaatttat ttttgttttt tactgtattc caattttaca agttctccaa
    19561 tattactagc tttcttaaaa ttcaaattag tcttgtctat accagactta aatagtgaaa
    19621 tccctctccc caatattatt ggcaatatat atatataata atcatcaatt aagttatctt
    19681 tcataaataa ttttactata tcgcctccac caactatcca aatatctttt ttatccttct
    19741 cttttccaat ttgctcaatt aattttttag gttctaaatt aatttatagt gtgattattc
    19801 tatgtaaaca tcactttttt actcattcaa taatacccta ttaataaatc ctcaaactaa
    19861 tttaaataaa ctttgcataa aattaaaaat atattatata aataatttaa aactacacta
    19921 acttattgaa aattctaatt attacaaata aatattgctc tctgttaacg ctagttctat
    19981 aatataatta taagctatta atattataaa gccgatatta ctaatataat aattataata
    20041 cttatagtta atttactttt gttgaaaggt ggtaaataac atgaaaattt cagaagtcgc
    20101 tactccaaat tttttgctag atttagacca gttagaaaag aatatagata aaattcaaca
    20161 aatttgtaca aataataata aacaactttg gcctatgctt aagacacata aaagtactta
    20221 catagcgaga cttcaaaaaa atgcaggtgc tagtggtttt ctagttggaa cacttgatga
    20281 aggtgaagct ctgataaaag caggttttga agatattatg ttggcttatc cttacatggg
    20341 agaagtaaat ataaatagaa ttgtgactat ggcatcaaaa ataaatttaa tctgtgctac
    20401 agataatata gaatgtgcta aggcttatag tgaagctttt tctaaatcaa aaatagagtg
    20461 caagctactt attattgtag attgtggctt acaccgtttt ggggttgaac cagaaaaagt
    20521 ggttgaactt gctactgaaa tttctaagct agaaaacatc aagattgttg gtataagttc
    20581 gcatccaggt caagtgtatg gttgtagttc tccagaaggt gttccagatg tttgtgttca
    20641 agaagattct tctatggaga aagcatacaa agctctaact gataatggat ttaatataga
    20701 aattgtcgct tctggtagta ctccaacagt tgaatctgaa gctgcttcta aaactataac
    20761 tgctgtaaga cctggaaact atgtatacta tgatgctata cagataggtt taggttgtgc
    20821 tactgaagat atgtgtgctc ttactgttgt gtgcactgta atctcaaaaa atagcagtgg
    20881 atactattta attgattgtg gaagtaagtg ccttggactt gataaaggtg cacatggaaa
    20941 tagtagtatt gttggttatg gtagggtatg tggacatcca gaacttacta ttgattcact
    21001 ttcagaagaa gttggaaaaa ttaaagtaaa tggtgaaact gatataaaaa ttggtgatag
    21061 aataagaatt atacctaatc attcttgttc cactgcaaac ttgacaagta atttattagg
    21121 ttttagagga gatacaatag aaaaagtcat agaagtagat attcgtgaaa attcaaaaca
    21181 aatcatcctt taaaaacaca tttattctga tattaacatg aaagtatatt tttcttaaaa
    21241 ttatttctaa taactaatgt taatgttgga taaataaaaa acataaattc tagaaatata
    21301 aatttaaaag aagaggctgt ctcaaaatag agataagcct ctctttcatt gttgaaatta
    21361 tgaaaatata cttgatttca tacaaaaaga gtatcttatg aactaaaaag ttcactttga
    21421 gatactctct ttttttaatt aatatacaca ttaattacta tcttagttta ttactatata
    21481 tcaattacta ctcattaatc cttgtatata ttaattctta tatatcattt atagttaggt
    21541 tataatttta tgttatttac attaatccca taacagtgag taaaactctt actattaaca
    21601 tccccactat tgcatcaaat ataggaactg ccaacagtaa cattctatac ttagtactgg
    21661 catttgctac aagcactatt ctggcataat gaccaactag agtacccatt aacatacatg
    21721 gcataattaa tatggttgct tgtggtgcag tgattagacc ttgtgcaaat aagtttgcag
    21781 ctgtagctgc tcctgctgcc ttagcaaaga atgctgctat caaaactaca acagattccc
    21841 caggtagtcc aaaaataccc attactggtc caaaaatatt tcctaaaata tcaactaaac
    21901 cagttaattg taaaaactgc actattacat aacccattat catggctggt aatatctgtt
    21961 caacacctat gtaaaaacct ttttttgctc cccccataaa tatctcaaca gcagttttct
    22021 taggtttact atttacaatt gcatttccag tattttgttg actcatacta cacagcctcc
    22081 ttagccttat tctttttatt tcttacacct atgattaatc taactagatt agcaccaagt
    22141 attttacaga atatctctat aaggattatt ggacctaatg ccaataatgc tattggtaaa
    22201 agtggagctt gagtatttat tgtgttcagt ataacagctg aaccagcata ttgatatgct
    22261 acaaatatag ttctttcatc atctgttatt tccccacttt caaataattc tttcgtcatt
    22321 attgaggcta catctgaact agtaaatgaa gatacaaatg ctattcctgc tattccaggt
    22381 ataccaagca gaggtctaag caatggatta aatatctttg atgccgcttt cattcctccc
    22441 atagattcaa ctacatctat aagacctaca gcaaaacaga cagttggaat caaagtcaga
    22501 gcaaataaga aaccatcttt tgctcccgtt cctcctttac ccataaagtc tacaccatct
    22561 gcaatagtac caaatgaacc tgtcagatta gcaaaatcta atgctttaag gaagccttga
    22621 ctatctttaa acactcctga aaataatact atcaatacaa ataaagataa ataccctttc
    22681 catgttacct tattatctcc agctgttaca tccatataaa atcccccttt atacctcaaa
    22741 tttatctaag tttaaaataa ctgtagaaat taatttcacc ctctcaaaca tagaatttac
    22801 tactgcatat tctcttgatg tgtggttcca ttcccctctt acaccaaatg aacagattgt
    22861 aggaacgttt gcaatagtta aataacttgc atctgaacta cctccaagtc tcttagcatt
    22921 taattctcca aatccatttt cctttgacac ttcatttaca aatgtatgaa atctcataac
    22981 atcttctgta gtttcaaatg gcatcatttc acttataaaa ttaacttctg tagaagttcc
    23041 ttctatgtaa gtttctttac atatctctct aacttgttct ttaacattct ccatttcttc
    23101 tactttttca aatctaaggt ctacttttat actacaatct tctggaatag aattttccac
    23161 tcttccaccc ttaatcacac ttacacttac tgtagttcca acatctaaat tagtcaattt
    23221 ttgtatgcgt agtatcttat tagccatttc ttctatagca tttcttccac cttcaaaatc
    23281 attacctgca tgtgtttcta caccttttac atgtatatta catcctattc ttccttttct
    23341 acctacacac aaactattat ctactaatcc agtttccata ttaaaagcac aaagaccacc
    23401 ttttgcttcc ctcaatataa catctgcacc tgttgaatcc ttatgtccta tctcttcatc
    23461 tccagaaaat actattttta ttggtctttc tttgtatcct attttattta aagctttaat
    23521 aacatataag gaaattatta taccaccctt catatctaaa acacctgggc catatgcttt
    23581 tccttctatt attttaaatg gattctctcc aaatgtacct gtttcaaaga cagtatccat
    23641 gtgacctgaa aaaattattg gctttttatc tatattggaa ccaagtgtac ctatcaatgt
    23701 actaccatta tctccaacat ctactaactc gcaatctaaa ccttcttttt caaactcaaa
    23761 ctttaatctc ttagccaatt tatttacgct ttctttacaa tgtgtatagc tttccatatt
    23821 aacaatctct ttccataatg aaactatttc ttctctattc tcatcaacaa acttagaaat
    23881 ttcatttaaa tatgtattca taatcttctc ctttattttc aaataaaatg tatttctttc
    23941 ctaaaatcta agtttatttt aggaaatctt aaaagactag tccttaatta caaaatagca
    24001 caattattct tgacagccaa catatttttc agtctttttt tatattttct gatttttctt
    24061 tcaattttcc ttttgtaaaa taaattgacg cgttttatct actattataa aatgaggtta
    24121 taaattgatt gattagttac aatactctcg aaattttaaa ggaggtttta tgaaatataa
    24181 aattggtttt ttgacaacat cttattttat gtcagataag tttaaacaag ctcttaaaga
    24241 attaaatgat acttgtgaaa ttacatttat tgagcttaaa ggggagaatc cttttaataa
    24301 tttacctaat atatactatg agcaagtaga taattttgat ggatttgtat gcagtggtat
    24361 agttccatat agtgaactta taataaatat aaaagacata aaagttccat taaatttttt
    24421 aaagcttgat gaaagagatt tttataaata cttattcaaa ttattaaata gccaaaaaga
    24481 tattgacttt acaaaatcat ttatggattt tttaagagag gacaacaatt attatgatat
    24541 atattcatta atagactcta ataaatgtcc atatacaatt aaagatttta atatccctca
    24601 acctgtatat gactttaaaa aattaaatga taaattattg gaaatacatt tagacttatt
    24661 gcgagataat aagattaacc tttcttttac tagaaattac atcattagtt gtgaacttaa
    24721 taagcttgga tatgattgta tttacatggt tccatctaca gaatcaatcc tgaatacatt
    24781 taaatctttg gtgaatgaaa taacattaca aaacttagac aaaaataaat ctgcaacttg
    24841 tatagttaca gtaaatagtt cagagtacat aaatgaagat ttgatattta aaaatgatga
    24901 gatacaaaat caaatatata acactatatt aaattctcta tcaagacatg gattctatgg
    24961 agttcaggtc aaaaaaaatg atatgaaaat agagatacac actactaaag aaatgttaaa
    25021 caatatgacc aataactata cagatttttt tatttcagaa gatttaaaag aaattaaata
    25081 tagcttaaat ataggttggg gcattggaaa tacaaatatt catgcagagc aaaatgctcg
    25141 tcaagctaat ggtaaatctg cttctttgaa tggaaactgt acttttatag taaatgatac
    25201 taatgataca ataggtcctt tatattcaaa taaaaattct aataatattg aagatagctc
    25261 aatagccaat aaagttgctt cttttatacc tctatctaat acaaatgtat ctaaaatcat
    25321 gtgtatgatt aatgatagaa attcaaataa tgtgtcagca gaaatattag cagactatat
    25381 gaacataact cttagaagtg ctaatagaat attgagtatc ttatataaag caggaattgc
    25441 aactattgta aatacaaaac tcgataatca aagaggaagg ccaaaaaaaa tatataaagt
    25501 tgatttctta tcttttctaa ataagatgca gaaattaaat tcttaatatt taatttttta
    25561 ataaaagcaa tgtattttct ctaattttaa agaatcaaaa tgtttaaatt ttattagaat
    25621 atacaacttt ttactttaaa atacctaaac cttttatcag tgaaataaac cataatatat
    25681 cgtaacttat tagaaaaaca aaataatttc atatacaaat aataaaatag ccactacaat
    25741 ccataatttg cagtggctac tttttacact atcacttatt acttattttt aaaaattaat
    25801 tgtatttttt aaataattta tacacaccta ttatcagtaa agcaataaat acaagtatat
    25861 ctataaaaat aattattgta acatgtctgg caatattgta aataaaaaat atagagaata
    25921 tttctataga caacgctaca aaacacataa aattcgttaa ataatctgca atagtatcac
    25981 tataaaagca tgtatttgta accatctcca tataaatgga cgtaaaagga ttctgaatac
    26041 aacacaaatg acagggtagg cataaataaa ttttttatct acataattag ctacaccatt
    26101 attccattgg ataggaattt gaggtggcaa ctttggaaat actgttattg caatttaaac
    26161 actacctctc tattctatta atttataact ataatatagt cttaaatatt ttcactctat
    26221 aaaattgtat atttagtata tcttaaaat
//
LOCUS       DAEQCW010000049        25999 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.049, whole genome shotgun sequence.
ACCESSION   DAEQCW010000049 DAEQCW010000000
VERSION     DAEQCW010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25999)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25999)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25999
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.049"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(114..893)
                     /gene="hisJ"
                     /locus_tag="KRO40_002043"
     CDS             complement(114..893)
                     /gene="hisJ"
                     /locus_tag="KRO40_002043"
                     /EC_number="3.1.3.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ"
                     /protein_id="HBH2092862.1"
                     /translation="MKDGHIHSPYCPHGSKDDFEKYVQRAMDVGITEMTFTEHFPYAN
                     GFRDPAPENDSCMSIEDLPKYFNDVKKLKEKYEGKIKINVGSEVDFIEGYEEGIKANL
                     NKYGEELEDSLLSVHIIKIDDDYYCVDYSVEEFQNLIDKLGSIEAVYNKYYETLIKAV
                     NSDLGIHKPKRIGHLNLVRKFNQVFPYDYKGNTILEELIKLIKEKGYELDYNVSGNRK
                     EYCKEPYIDGYLLELVKKYDIPLVLGSDSHCAEEINKYDII"
     gene            complement(1439..1789)
                     /locus_tag="KRO40_002044"
     CDS             complement(1439..1789)
                     /locus_tag="KRO40_002044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter"
                     /protein_id="HBH2092863.1"
                     /translation="MIFDKEIVRYHHGHHDHDHCHEHTHGDICHEHPHDHAHDHDHEH
                     SHEESSESKDEKTLKILLVHWINHNETHEEGFREWVEKARAIGKEETAKSIEKAIEYM
                     EEANKMLLEAKKHM"
     gene            complement(1805..2221)
                     /locus_tag="KRO40_002045"
     CDS             complement(1805..2221)
                     /locus_tag="KRO40_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3842 family protein"
                     /protein_id="HBH2092864.1"
                     /translation="MIIAVIDGMGGGIGAQIVSSLREELPTYVEIYALGTNSIATSSM
                     MKAHANKGATGENAIVVSAKKANIIVAPISVIIPNSMMGEVTCNISEAIADSEALKIL
                     LPIMPENVELVGLEGKPLALLVKDSVNLIKKEFNIK"
     gene            complement(2240..2431)
                     /locus_tag="KRO40_002046"
     CDS             complement(2240..2431)
                     /locus_tag="KRO40_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CooT family nickel-binding protein"
                     /protein_id="HBH2092865.1"
                     /translation="MCESSAFICKSNNELEKVMENVVNIDPCDGKIYLTDLLGEQKII
                     DGIIKEIRLMDHKIIIQEN"
     gene            complement(2582..3397)
                     /locus_tag="KRO40_002047"
     CDS             complement(2582..3397)
                     /locus_tag="KRO40_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase family protein"
                     /protein_id="HBH2092866.1"
                     /translation="MNQWRVIHNKSYEGAMNMAIDEAIFTAYKKGHNKPTLRFYTWEP
                     ACLSIGYFQKLEDEIDLDKCRCMNIDYTRRITGGRAVLHDNELTYSIIIGEDNPLIDK
                     SINLSYRYISEGLVKGLNLSGIETDNLNRGERISRENLSAACFNAHASYEVTINNKKV
                     IGSAQSRKDGVLLQHGSIILDFDVEKLFKLIKTKTPELKERAMKFTAKKASGIENEIG
                     RKIDIDILQKNIVKGLAEQFNVEFVEGDLTDYEKQLVKELYEKYKNEEYNKKR"
     gene            complement(3444..4382)
                     /locus_tag="KRO40_002048"
     CDS             complement(3444..4382)
                     /locus_tag="KRO40_002048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092867.1"
                     /translation="MIRLSVGTAIELGILNKKSDIPPTTAYIMIGEKCINKCSFCSQS
                     IESSTRKDKLSRVIWPEFSKEEILDALKAYKGKNIKRICIQSMASEEAHNSVLDFINY
                     ISGKIDMPISLSAKLENDEQIKKFFSAGVNKIGIAIDAANKELYEKIKGNNYDEKLKF
                     ITEMSKSYPNKISTHIIVGMGESHEDIYNLYTYLKENDVTISLFAFTPVRGTKMEKIS
                     QPSIESYRRVQLMSYMINKGYPKEYFKFKNGYLNSIKLDNDILKDINKGYPFEIRGCK
                     DCNRPYYNERPGSTIYNYSRPLNQSEIDLAIREINL"
     gene            complement(4379..5251)
                     /locus_tag="KRO40_002049"
     CDS             complement(4379..5251)
                     /locus_tag="KRO40_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2092868.1"
                     /translation="MNKNLSEKMKIAFDIKLKNFGNKIEFAYPNQTLALSTTSNQCSL
                     KCAHCNGHYLNNMVPIEEYEEKVQSRNITSFLLSGGCSYEGDVPINTHINTIKNLKEQ
                     GYRLNAHLGLMDKDSIVELCKYLDIVSFDLVFDDETIREVYKMKKSKEDYIEVYNTIQ
                     EHTEVAPHICIGLKGGQIKGEYEIIEYLQKNPPNKLTFIVLIPTKGTEYENVEPPELE
                     GVADILCEARINLPDTEINLGCMRPRGVYRKELDQLSIMCGVNRIVLPSRSAKNKAIE
                     MNMTINECKECCVL"
     gene            complement(5276..7204)
                     /locus_tag="KRO40_002050"
     CDS             complement(5276..7204)
                     /locus_tag="KRO40_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4445 domain-containing protein"
                     /protein_id="HBH2092869.1"
                     /translation="MIKVSFTPNNKEVYCNEGDILLEVARNADIFIDAPCNGNVSCGK
                     CKVKLLNGKVDTEKTRHITDDEWEQGYILACCTKVISDIEIEVPSKVSSSMHGMKIEG
                     SNKKEDREIFERAKKIIEEHNLQFKTNIKKKYIEMEEPNLDDNISDVDRLERYVRNNL
                     GYNEIDFRLDILRKMPTVFRKSDFKVTITYVQKQKKLTIINIEQGNKENSLYGVAIDI
                     GTTSVVVCLVDLYSKEVVDKASSGNAQIKYGADVINRIIYSTKKNGLETLHKAIVEET
                     INPLLKTIYERNGIDKEDVVTLVAAGNTTMTSLFLGVYTDFLRQEPYIPPFLKSPKLM
                     GENVGLFVNDSAYVYLAPSVASYVGGDITAGVLSAGIWSSEENVLFIDLGTNGEIVFG
                     NKDYMMSCACSAGPAFEGGGISCGMRASAGAIEKVIIDKDTLEPTLKIIDECAPVGIC
                     GSGIIDLICQMITKGVIDRRGKIYRDLDNKRVRFNEHEIGEYVLAFKEEFDLENDIVV
                     NEVDIDNFIRAKGAIYSGAYTLVDSLGMDFSILDRVYIAGGIGNNLDIENSIIIGLLP
                     DIDREKFTYIGNSSLVGSYLALISKDAKNKLEEIGNQITYVELSVYPSYMDEFISACF
                     LPHTNIEQFPTAKKLLEE"
     gene            complement(7316..7693)
                     /gene="gcvH"
                     /locus_tag="KRO40_002051"
     CDS             complement(7316..7693)
                     /gene="gcvH"
                     /locus_tag="KRO40_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="HBH2092870.1"
                     /translation="MKLLPELKYSKDHEWVKVIDGDVVYIGITDYAQDQLGEILFVET
                     PEVEDTVTKGVDFGVVESSKVASDLISPVNGEVLEVNEKLEDEPECINEDPYENWILK
                     VKLADVAELDTLLSDKEYEAGLE"
     gene            complement(7780..9906)
                     /gene="cdhC"
                     /locus_tag="KRO40_002052"
     CDS             complement(7780..9906)
                     /gene="cdhC"
                     /locus_tag="KRO40_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CO dehydrogenase/CO-methylating acetyl-CoA
                     synthase complex subunit beta"
                     /protein_id="HBH2092871.1"
                     /translation="MNLYNIIFTGSEQALGAAQAMLAEAIEKNGKEHKVAFPDTAYSL
                     PCIYAATGQKMNTLGDLEGALEVVKSLINRTHLLEHAFNAGLATALAAEVIEALKYST
                     MDAPYSEPCAGHITDPIIRSLGVPLVTGDIPGVAVVLGECPDAESAAKVIKDYQSKGL
                     LTFLVGKVIDQAIEAGVKMGLELRVIPLGYDVTSVIHVVSVAVRAALIFGGLTPGDLN
                     GLLEYTANRVPAFVNAFGPLSELVVSAGAGAIALGFPVITDQTVLEVPMNLLTQKDYD
                     KIVATSLEARGIKIKVTEIPIPVSFAAAFEGERIRKSDMFAEFGGNRTEAWELVVKKE
                     ATEVEDHKIEIIGPNIDEVDADGVLRLPLAVIVKIAGKNMQEDFEPVLERRFHYFLNY
                     IEGVMHVGQRDMAWVRISKDAFDKGFRLEHIGEVLYAKMLDEFESVVDKCEITIITDA
                     EKVSELKGEAIAKYNARDERLASLVDESVDTFYSCNLCQSFAPAHVCVVTPERLGLCG
                     AVSWLDAKATKELDPTGPCQPIEKGECLDDRTGVWNSVNETVNQISQGAVESVTLYSI
                     LEDPMTSCGCFECICGIMPEANGFVVVNREFASVTPVGMTFGELASMTGGGVQTPGFM
                     GHGRHFISSKKFAYAEGGPERIVWMPKELKDYVADKLNATVKEMTGIENFCDMVCDET
                     IADDSEGVLAFLEEKGHPALAMESVM"
     gene            complement(9963..10769)
                     /locus_tag="KRO40_002053"
     CDS             complement(9963..10769)
                     /locus_tag="KRO40_002053"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBH2092872.1"
                     /translation="MEKFMIIGERIHCISPSIRKALAERDPAPILKRAKEQLEAGAHY
                     IDFNIGPAERDGEEIMTWGIKLLQSEFNNVPIALDTANKKAIEAGLKVYDRTNAKPII
                     NSADAGSRFDLIDIAAEYEAMVIGLCAKEGIPRDNDERMAYCQEILEKGLMLGMEPTD
                     ILFDPLCLVIKGMQEKQVEVLEAIKMMTEMGLLTTGGLSNVSNGCPKHVRPVLDSAFL
                     AMAMANGFSSAIMNPCDPELMKTVKSCDIINGASLYADSFLELNEGGFAF"
     gene            complement(10819..12186)
                     /locus_tag="KRO40_002054"
     CDS             complement(10819..12186)
                     /locus_tag="KRO40_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit gamma"
                     /protein_id="HBH2092873.1"
                     /translation="MALKALDIFKLTPKKNCKDCGFPTCMAFSMKVASGAVEVGKCPH
                     MSDDAIAKLSEATAPLMKALKVGAGASEYELGGETVLFRHEKTLVSRNRYAVSFCTCM
                     SDEAVDAKIANMKKVDYVRIGEQMKVEMAVLEYCGDKDAYLKLIDKIKGSGLEVAYIL
                     ACDDAQVVKEAVEVLKDARPMVYGATKENYKDMIEVVKGASLPLGVKAGSLEELYETV
                     ELIQAAGYKELVLDVTGENIKDTYTNAIQVRRTALKEQDRTFGYPSIVFANRLSNSNP
                     MMEVALSSIFTIKYGSIIVIDDISYAKALPLFALRQNIYTDPQRPMRVEPKIYPINNP
                     DENSPVLVTVDFALTYFIVAGDIERSKVPVWLVIPDAGGYSVLTSWAAGKFGGNSISA
                     FIKESKVEEVTNCKDLIIPGKVAVLKGDIEDNLPGWNVVIGPEESMELPKFLKGYQEK
                     ACQTN"
     gene            complement(12217..13161)
                     /locus_tag="KRO40_002055"
     CDS             complement(12217..13161)
                     /locus_tag="KRO40_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit delta"
                     /protein_id="HBH2092874.1"
                     /translation="MAFKMSTQKYSGKISEVEVGIGEKAIKLGGENVLPFYSFDGEVG
                     NSPKIGIQISDVYPESWTDSYKELYKDVANCPVEWAKYVEANTQADFICLKFDGSDPN
                     GLDKSVDECADVAKAVIEAIKLPLVVAGSGNHEKDGKLFEKLAQTLDGHNCLFMSAVE
                     DNYKGVGASAGMAYAHKVGAESSVDINLAKQLNVLLTQLGVKGENIVMNVGCSAVGYG
                     YEYVASTMDRIRLAAFGQNDKTLQMPIITPVAFEVGHVKEAIAPIEDEPDWGCPEERT
                     IAMEVSTAASVLVGGSNAVILRHPKSIETIKELVNALA"
     gene            complement(13181..13951)
                     /locus_tag="KRO40_002056"
     CDS             complement(13181..13951)
                     /locus_tag="KRO40_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2092875.1"
                     /translation="MGYNIAVAGKGGTGKTSLTGLLIDYLVKDKKGPVLVVDADANAN
                     INEVLGIEVEATIGEIREEVNQREKLGNAFPGGMTKAQYLQFRLNSIIEEGEGYDLLV
                     MGRSEGEGCYCFVNGILREQVNKISGHYKYLVMDNEAGMEHLSRKVTRHVDTLLLVSD
                     CSRRSIQAVARIRDLAEELKLSVGRILLIVNKVPNGVMNDGVKEEIEKHNLELIGVVP
                     MDELIYEYDSTGIPLVNLPEDSKSKVAMKEIFAKLELK"
     gene            complement(14007..15392)
                     /gene="lpdA"
                     /locus_tag="KRO40_002057"
     CDS             complement(14007..15392)
                     /gene="lpdA"
                     /locus_tag="KRO40_002057"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBH2092876.1"
                     /translation="MKIVVVGGGPGGYVAAIKASMLGADVTVVEKRRVGGTCLNAGCI
                     PTKALLASSGVLNTVKEAKDFGIEIDGTVKPNFTAIMERKNKVVNQLISGIEFLFEKR
                     GVNLVNGFGKLIDKNTIEVTKDDGTVETIKADKIILANGSVPVVPRMFPYDGKVVITS
                     DEVLGLEEIPESMLIVGGGVIGCEIGQFFRALGTEVTIVEMVDQILLNEDKDVAKQLL
                     RQFKKDKIKVITGIGVQTCEVVDGKAVATLSNGKVIEAQYALVCVGRRPNLDNSGVED
                     IGIEMERGKVVVNEHLETNVEGIYAIGDIIDTPFLAHVASKEGIVAVENALGKTKVVD
                     YRAIPRCVYTEPEVAGVGKTEKQLEAEGVEYNVGQFDFRGLGKAQAIGHFQGFVKVIA
                     DKETDKIIGAAVVGPHATDLLTELSLAVHLGLTVEQVGDAIHPHPSLSEGLMEALHDV
                     HGECVHSVPKL"
     gene            complement(15436..16317)
                     /locus_tag="KRO40_002058"
     CDS             complement(15436..16317)
                     /locus_tag="KRO40_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="HBH2092877.1"
                     /translation="MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAA
                     NVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLL
                     ALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTP
                     EYSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSP
                     GMAKFMTANVPGIFVPDEQIERLRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIM
                     AIGAEENIPAILDAAGL"
     gene            complement(16353..17027)
                     /locus_tag="KRO40_002059"
     CDS             complement(16353..17027)
                     /locus_tag="KRO40_002059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase C-terminal
                     domain-containing protein"
                     /protein_id="HBH2092878.1"
                     /translation="MIISENKPLEEVLGYLKDFDKLVLVGCNQCAATCKSGGEEEVLK
                     MKETLEGEGKKILGYVMLDPACNLLKSKKDLKALKEETKEADAVLSLACGDGTQTIVK
                     NLKDKPVYPANNTLFIGEVQRVGEYEEACKACGDCELGWTGGICPVTMCAKGLMNGAC
                     GGAKNGKCEVNSENDCAWIKIYERLEAIGQLDNLAEIRPPKDYSKQNNPRSLSAKKKK
                     EAAANS"
     gene            complement(17062..17934)
                     /locus_tag="KRO40_002060"
     CDS             complement(17062..17934)
                     /locus_tag="KRO40_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 5,10-methylene-tetrahydrofolate
                     dehydrogenase/5,10-methylene-tetrahydrofolate
                     cyclohydrolase"
                     /protein_id="HBH2092879.1"
                     /translation="MEGMSTKGQIIKGKPVADKISEELIKEVDLLVKEGINPKLTIVR
                     VGARSDDLSYERGALKRCQNIGITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCF
                     RPLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNV
                     DLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHSKTKNLSGVAAEADVLIAAIGRA
                     KMVDESFVKDGAVVIDVGINVDEEGNLCGDVDTNAVLDKVSMITPVPAGVGSVTTSIL
                     AKHVVKACKLQNNK"
     gene            complement(18026..18658)
                     /locus_tag="KRO40_002061"
     CDS             complement(18026..18658)
                     /locus_tag="KRO40_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclodeaminase/cyclohydrolase family protein"
                     /protein_id="HBH2092880.1"
                     /translation="MKIADKTCVDFVEVLSSKEAVPGGGGAAALVGAIGMALGSMVCN
                     LTIGKKKYAEYEESVKEILSKAGKLEKDLLKMIDDDAECFLPLSKAYGLPKETEEEKR
                     IKAETMEKALKVACEVPLNIVRVCYEAIKLHEDLVDKGSRLAISDVGVGVQCLRAAIL
                     GGQLNVVININSIQDKEYVNKVKTEVDKLVEDGVKICDEVYAKVEKALGK"
     gene            complement(18763..20439)
                     /locus_tag="KRO40_002062"
     CDS             complement(18763..20439)
                     /locus_tag="KRO40_002062"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014355320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HBH2092881.1"
                     /translation="MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDY
                     NLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVADAFAKLDKNVLVALREPSLGPV
                     FGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPK
                     KITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKE
                     RLGNIIVGYSYEGEPVTARQLKANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANI
                     AHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMANLKPDAVIIVATVRA
                     LKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELK
                     LVEDKCKELGVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKI
                     NAIATKIYGADGVDYTPEADKEIANLEKLGFTKVPVCMAKTQYSLTDDQTKLGRPTGF
                     RITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF"
     gene            complement(20688..21467)
                     /locus_tag="KRO40_002063"
     CDS             complement(20688..21467)
                     /locus_tag="KRO40_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2092882.1"
                     /translation="MKIAITGKGGVGKTTFSSMLSRMFAEDGYRVVAVDADPDANLAL
                     ALGFPKEVYESIVPISEMKKLVSDRTAASVGSFGKMFKMNPKVDDIPENFCKEYNGVR
                     LLTLGTVDSGGTGCVCPEHVLLKRLCSHLILQNKDVVVMDMEAGIEHLGRGTAQGVDA
                     FIVVVEPGERSLQTYRKVKKLGHDIGVNKVFVVGNKIRNKEDEEFIIQNLEDGESLGF
                     IYYNQDVIDSDRANQSPYDSSETTKEQIKAIKDKLMSLKDK"
     gene            complement(21777..23696)
                     /gene="cooS"
                     /locus_tag="KRO40_002064"
     CDS             complement(21777..23696)
                     /gene="cooS"
                     /locus_tag="KRO40_002064"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBH2092883.1"
                     /translation="MDEKMLTIDLNSQKMIAKAREEGVETMYDRKEGFKAQCGFGLQG
                     VCCRICGMGPCRISPKTPRGLCGADEHTIVGRNFARMVAGGTAAHSDHARDIAHTLAL
                     ADPNGNYKIRDEAKLITLAKEWDVETEGRDIYDVAHEVAEIALMEFGKPFGTLRFIKN
                     APEPRQKIWKEYAIEPRAIDREIATIMHSTHIGCTGDIDSLIHMSLRTSMADGWGGSM
                     IGTRLSDILFGTPVPRRTEANLAVLEENKVNIILHGHEPALSEMIVLASEEPDLVALA
                     KEVGADGINLAGMCCTGNEITMRHGVKIAGDFHQQELAIITGAVEAVIVDVQCIFPAL
                     ARVADCYHTKFVTTSPKAKITGSTYIEFREEQALDDAKAIVKEAILNFKNRDKSKVLI
                     PELKSGATVGYSVEAVVNQLDRVVNSHIDPAGTVKPLTDCLKAGVLRGAAGVVGCNNA
                     KGVSNEAHVTIMKELIKNDIIVVTTGCGASAAAKFGLMESDAAEKYAGKGLATVCKLV
                     GIPPVLHMGSCVDISRILDLVGAAANYLDMDMCDLPVVGIAPEWMSEKAVAIGCYVVA
                     SGIDTYLGIMPPIAGSSRAVDILTSELKDKVGATFTVNTNPKELAATIIEDIEKKRVH
                     FEALVEEKMTEKAEA"
     gene            complement(24303..25214)
                     /locus_tag="KRO40_002065"
     CDS             complement(24303..25214)
                     /locus_tag="KRO40_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBH2092884.1"
                     /translation="MIKKLDDILEQLKGGEKIVLSVAAAHDKEVLMAIKDAVERNIIT
                     PILVGNEGKIREISKEIGFDLSGIKIVDKDDIKECAEIAVKLVSSKEADFVMKGLLDT
                     SVILKEVLNKDYGLRTDSLLSHVMVYELEKYHKLLITTDGGMNIAPDYEQKAKILKNS
                     IKAAKALGMETVKVACLAAKEKVNPKMQATVDADMLAKACKEGEFGENVIVEGPLAFD
                     LAVSKEASEIKGFKSEVSGDVDIILVPTIEVGNGIGKAFTYMADSKSAGIIMGAKAPI
                     VLVSRADSHESKLYSIAYGAIVAKNMK"
     gene            complement(25330..25908)
                     /locus_tag="KRO40_002066"
     CDS             complement(25330..25908)
                     /locus_tag="KRO40_002066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH2092885.1"
                     /translation="MNINEFLTHINQRKPVSSKSEIHEFMVKLSNEAMKITSKLNSSY
                     HEPEEVRSLFSELIGKKVDESFFMFPPFYTDCGKNITIGKNVFINSSCHFQDQGGIDI
                     GDNTQIGHNVVLATLNHGIAPEKRGTTYPSPITIGKNVWIGANVTIVPGVTIGDNVII
                     AAGAVVTKNVAENTIVGGVPAKLLRVIDEIPE"
BASE COUNT         7611 a         5342 c         2943 g        10103 t
ORIGIN      
        1 ttattattat tttatttaag ttctattact attttcaatc atataaattt acaaaagact
       61 gtacataaat ttattttata caaacttatc tacagtcttt tgtgtgaata tatctaaata
      121 atatcgtatt tatttatttc ctctgcacag tgagaatcag aacctaaaac taatggaata
      181 tcgtattttt ttaccaactc taataagtat ccatctatat aaggctcttt gcagtactct
      241 tttctatttc cagaaacatt ataatcaagt tcataacctt tttctttaat taactttatt
      301 aactcttcaa gaattgtatt tcctttataa tcgtatggaa atacctgatt aaactttcta
      361 actaaattta aatgacctat tctttttggt ttatgtatac ctaaatctga atttacagct
      421 tttatcaatg tttcataata cttattataa acagcttcaa tacttcctaa cttgtcgatt
      481 aaattttgaa actcctctac actgtaatct acacaataat aatcatcatc aattttaatt
      541 atatgtactg ataaaagaga atcctctaat tcttctccat atttatttaa attcgccttt
      601 atcccttctt cgtatccttc tataaaatcc acttccgacc caacatttat cttgatttta
      661 ccctcatact tttctttcaa cttcttgaca tcattaaaat actttggtaa atcttcaata
      721 ctcatacaac tatcattttc aggagcaggg tctctaaatc catttgcata cggaaaatgt
      781 tctgtaaatg tcatttctgt tattccaaca tccattgctc tttgtacata tttttcaaaa
      841 tcatccttac ttccatgagg acaataaggt gaatgtatat gaccatcttt cataaataat
      901 tcactccttt tttaaagaaa aaatctaata taaatgcata aatcttttaa cttcaaaata
      961 atatttttaa tcatgctaat ttttattata tctaatatta gagtaatttt aaactgcctt
     1021 ttaagtatct tatcattagt actattttca acttaacatt aatattattt tttaacttaa
     1081 cattaatact atctttaaat agtaatactc aatatataat tacttaacat aaaataactc
     1141 aaattgcttg atgaggcttt tgcagtattt aaagaatata taattattta acattaaatt
     1201 atccaatctt gtaataaaat ttactcatta aagtatatta cagaaaatac ctcaaaataa
     1261 actttttagt tcatgagata ctctttttta catgaaatta gatatatttt tatcatttca
     1321 acaatgaaag ggaggcttat atccatcttt agacaacccc ttagataaaa tttttaataa
     1381 ttaagcatca caaaatataa aaatcgctta tatcaaacgt ataagcgatt aattatattt
     1441 acatatgttt tttagcctct aacaacattt tattagcttc ttccatatac tctatagcct
     1501 tttcaatact ctttgctgtt tcttcttttc caatagctct agccttttca acccactctc
     1561 taaatccttc ttcatgagtt tcattgtgat ttatccaatg tactaaaagt atttttaaag
     1621 ttttttcatc cttagactct gatgattcct catgactatg ttcgtggtcg tggtcgtgag
     1681 catggtcatg tggatgttca tgacatatat ctccatgagt atgttcgtgg cagtggtcat
     1741 ggtcatgatg tccatgatga tatcttacaa tctctttatc aaaaatcatt agttattccc
     1801 cctgttattt tatattaaac tcttttttta taaggtttac agaatctttt acaagtagtg
     1861 ctaatggttt accttctaat ccaactaact ccacattttc tggcataata ggtaaaagta
     1921 tcttaagtgc ctcactgtct gcaatagctt cacttatatt acaagtaact tctcccatca
     1981 tagaattagg tattattaca gaaataggtg caactattat atttgctttt ttagctgata
     2041 ctactatagc attttcccct gtagctcctt tattagcatg agctttcatc atagaactag
     2101 ttgctataga attagtccct agtgcataaa tttctacata tgtaggtaac tcttctctca
     2161 aagaagaaac tatctgggct ccaatacctc cacccattcc atctatcact gctattatca
     2221 tatgaaattc ccctattaat taattttctt gtattattat cttatggtcc atcaatctta
     2281 tttctttaat tatcccatct attatctttt gctctcctaa taaatccgtt aaataaatct
     2341 ttccatcaca agggtctata ttaaccacat tttccataac cttttctaac tcattattac
     2401 ttttacaaat gaaagctgat gattcacaca tataaatctc ctcctaatat gatttttatt
     2461 aaaaatcaaa aaaagattcc cttaggtatt tcaatacacc aaagaaacct tcatgatttc
     2521 agtttttgta tattattata ccttaagtat atcactttaa tttatgtaaa gtcaattaaa
     2581 gttaacgctt tttattatac tcttcattct tgtatttttc atatagttct ttaactaatt
     2641 gcttctcata atcagtcaaa tcgccctcca caaactcaac attaaattgt tcagctaatc
     2701 cctttactat gtttttctgt agaatatcta tgtctatttt tctgccaatt tcattttcta
     2761 ttccacttgc ttttttagct gtaaatttca tagctctttc tttcaattct ggtgtcttag
     2821 tttttattaa tttaaacaat ttttctacat caaaatccag tattattgaa ccatgttgta
     2881 ataaaacacc atcttttctg ctttgagcac ttccaattac cttcttatta ttaatagtaa
     2941 cttcatatga tgcatgtgca ttaaaacatg cagctgataa attttcccta cttattctct
     3001 cgcctctatt taaattatct gtttctatac cacttagatt caacccttta actagacctt
     3061 cacttatata tctataagat aggttaatgc tcttatcgat taaaggatta tcttctccta
     3121 taattatact ataggttagc tcattatcat gtaatacagc tcttccacct gtaattcttc
     3181 tagtatagtc tatattcata catctacact tatctaaatc tatctcatct tccaatttct
     3241 gaaaatatcc tatactcaaa caagctggtt cccatgtata aaatctaaga gttggcttat
     3301 tatgtccttt cttatatgca gtaaatatag cttcgtcaat tgccatattc attgctcctt
     3361 catatgattt attatgtata actctccact gattcatgat tattacgccc ccatttttag
     3421 tataaatata tcctagaaat cctctataga tttatttctc ttattgctaa atctatctca
     3481 ctttgattta aaggtcttga atagttgtat atagtacttc ctggtctttc attatagtat
     3541 ggtctattac aatccttaca acctcttatt tcaaaaggat agcctttgtt tatgtctttt
     3601 aaaatatcat tgtcaagctt tatactattt aagtatccat ttttaaactt aaaatactct
     3661 tttggataac ctttatttat catataagac attaactgta cccttctata actttctatg
     3721 cttggttgac ttatcttttc cattttagtt cctctaactg gagtaaatgc aaataaacta
     3781 atcgttacat cattttcctt taaataagta tataaattgt atatatcttc atgactttca
     3841 cccataccaa ctattatatg tgtacttatt ttattgggat atgattttga catttcagtt
     3901 ataaatttta acttttcatc atagttattt ccttttattt tttcatatag ttctttattt
     3961 gctgcatcta ttgctattcc tattttattt actcctgctg aaaaaaactt ctttatctgt
     4021 tcatcatttt ctaattttgc agatagtgaa attggcatgt ctatcttacc acttatatag
     4081 tttataaagt ctaaaacaga gttatgtgct tcttcacttg ccattgattg aatacatatt
     4141 ctctttatat tttttccttt ataagctttt aaagcatcta atatttcttc ttttgaaaac
     4201 tctggccaaa ttactcttga taatttatct tttctagtac tactttctat tgattgagaa
     4261 caaaaactgc atttatttat gcatttttct ccaatcatta tatatgctgt ggtaggaggt
     4321 atatcgcttt ttttgtttaa tatcccaagt tctattgctg tcccaactga tagtctaatc
     4381 ataaaacgca acactcctta cactcattta ttgtcatatt catttctata gccttattct
     4441 ttgcagacct tgatggtaat actattctat tgactccaca cattatagat aattggtcta
     4501 gctcttttct atacactcct cttggtctca tacaacctag attaatttca gtatctggta
     4561 aattaattct agcttcacat aaaatatctg ctaccccttc taactcagga ggttctacat
     4621 tttcatactc agtccctttt gttggaataa ggactataaa tgtaagctta ttaggaggat
     4681 ttttttgtag gtattctata atttcatatt caccctttat ttgtcctcct tttaaaccaa
     4741 tacatatatg tggtgctact tctgtatgtt cttgtattgt attatagact tcaatataat
     4801 cttctttact ctttttcatc ttataaactt ctcttattgt ctcatcatca aacactaaat
     4861 caaaagaaac tatatctaaa tacttacaca actctacaat gctatcttta tccataagac
     4921 ctaaatgagc attcaatcta tatccttgct cttttaagtt tttaatggta ttaatatgag
     4981 tatttatagg gacatctccc tcataactac aaccgccact caatagaaag ctagttatat
     5041 tccttgattg tactttttcc tcatattctt ctattggcac catattgttt aagtagtgac
     5101 cgttgcaatg ggcacatttc aaactacatt gattgcttgt agtactaaga gctagtgtct
     5161 ggttaggata agcaaactct attttatttc caaaattctt taatttaata tcaaatgcta
     5221 ttttcatttt ttcagataga ttcttattca tagtttattc cttcttaagt acattttact
     5281 cttctagtaa tttctttgct gttgggaact gctctatatt cgtatgtggt aagaaacatg
     5341 cagaaataaa ttcatccata taacttggat atacactaag ttcaacataa gttatttgat
     5401 tacctatttc ttcaagttta ttttttgcat ctttacttat aagagctaag taagaaccaa
     5461 caagtgaact attccctata taagtaaatt tttctctatc gatatcagga agtaacccta
     5521 taattattga gttttctatg tctaggttgt ttcctatacc acctgctata taaaccctat
     5581 ctaatatact aaaatccata cctaaactat ctacaagagt gtatgcgcct gaatatatag
     5641 ctcctttagc tctgatgaaa ttatctatat caacttcatt gactactata tcattttcta
     5701 aatcaaattc ttctttaaat gctaatacat actctcctat ctcatgctca ttaaatctaa
     5761 ctctcttatt atctaaatcc ctgtatattt tacctcttct atctattaca cctttagtaa
     5821 tcatttgaca gattaaatca attataccag aaccacatat accaactggt gcacattcat
     5881 caataatctt taatgttggc tctaaagtat ctttatcaat aattactttc tctattgctc
     5941 ctgctgatgc tctcattcca cagcttatcc ctccaccttc aaaagcaggt cctgctgaac
     6001 atgcacagct catcatataa tctttatttc caaatacaat ctctccatta gttcctaaat
     6061 ctataaataa aacattttct tcacttgacc atatccctgc tgataatact cctgctgtta
     6121 tatctcctcc tacataactt gcaacagatg gagctaagta cacatatgca ctgtcattta
     6181 caaaaagacc aacattttca cccataagtt ttggagattt taaaaatggt ggtatgtaag
     6241 gttcttgtct taagaagtct gtatacacac ccaagaataa acttgtcata gttgtattcc
     6301 cagcagccac taatgtaact acatcttcct tatctattcc atttctttca tatattgttt
     6361 ttaatagtgg atttatagtt tcctcaacta tagctttatg aagtgtctct aatccatttt
     6421 tcttagttga atatataatt ctatttataa catctgctcc atattttatc tgtgcatttc
     6481 cagaagatgc tttatctact acctcttttg agtataggtc tactaaacaa acaactactg
     6541 aagttgtacc aatatctatt gcaactccgt ataaggaatt ttctttattt ccttgttcta
     6601 tatttatgat tgtaagtttc ttttgttttt gaacatatgt tattgtaacc ttaaaatcac
     6661 tctttctaaa tacagttggc atttttctaa gtatatccaa tctaaaatct atttcattat
     6721 atcctaggtt atttctaaca tatctttcca atctatctac atcacttata ttatcatcta
     6781 aatttggttc ttccatttct atgtatttct tttttatatt tgttttaaat tgaaggttat
     6841 gttcttcaat tattttttta gctctttcaa aaatttccct atcctctttt ttattactac
     6901 cttctatctt cataccatgc atagaggatg atactttaga aggaacttca atttctatat
     6961 ctgatattac ctttgtacaa caagctagta tataaccttg ctcccactca tcatctgtta
     7021 tatgtcttgt tttttctgta tcaacttttc cattcaataa ttttacttta cacttcccac
     7081 aagacacgtt tccattacaa ggagcatcta tgaatatatc tgcatttctt gcaacctcta
     7141 gtaatatatc cccctcatta caataaacct ctttattgtt tggtgtaaaa cttactttta
     7201 tcatgttatc cctcccaatt tgttctatat atgataaaag gaaagtatag ctaaatttgc
     7261 gtgcactcaa attttactat actttcccca attataataa tatcttaatc tttaattatt
     7321 ctaatccagc ctcgtattct ttatcactta ataacgtatc aagttcagcc acatcagcta
     7381 gttttacttt taatatccag ttttcatatg ggtcttcatt tatacattct ggctcatctt
     7441 ctaatttttc attaacttcc aatacctcac cattaacagg agatattaaa tcagaagcta
     7501 ctttagaaga ctcaactact ccaaaatcta ctcccttagt tacagtatct tctacttctg
     7561 gtgtttcaac aaacaatatt tctcctaatt gatcttgagc atagtctgtt atacctatat
     7621 atacaacatc tccatcaatt acttttaccc actcatgatc tttagagtat tttaattctg
     7681 gtaataattt catttcgata gacccccaat attatattat tgattaaatt acttaaatca
     7741 tattaatatt atatcatatt attttaaatt ttccatcaat tacattacac tttccatagc
     7801 taatgctgga tgaccttttt cttctaagaa agctaatact ccttcagaat cgtcagctat
     7861 agtttcatca caaaccatat cacagaagtt ttctattcca gtcatttctt taactgtagc
     7921 atttaattta tcagctacat aatcttttaa ttcttttggc atccaaacta ttctttctgg
     7981 tccaccttct gcataagcga attttttaga agatatgaaa tgtcttccgt gtcccataaa
     8041 tcctggagtt tgaactcctc cacctgtcat agaagcaagt tctccgaaag tcataccaac
     8101 tggagtaaca cttgcaaatt ctctgttaac tacaacaaat ccatttgctt ctggcattat
     8161 accacagata cattcgaagc atccacaaga agtcattggg tcttctagta tagagtataa
     8221 tgtaacagat tcaactgcac cttgagatat ttggtttaca gtttcattta ctgaattcca
     8281 tacacctgtt ctatcatcta agcactcgcc tttttctatt ggttgacaag gacctgttgg
     8341 gtctaattct ttagtagcct tagcatctaa ccagctaact gctccacaaa gaccaagtct
     8401 ttcaggagta acaacacaaa cgtgagctgg tgcaaatgat tgacataagt tacaagaata
     8461 gaaagtgtca acactttcat caactaatga agctaatctt tcatctctag cattgtactt
     8521 agctattgct tcacctttta attcagaaac tttttcagca tctgtaatta tagttatttc
     8581 acacttatca actactgatt caaattcatc taacatctta gcatataaaa cttctcctat
     8641 atgctcaagt ctaaatcctt tatcaaatgc atctttagag attcttaccc aagccatatc
     8701 tctttgtcca acgtgcatta caccttctat atagtttaag aagtagtgga aacgtctttc
     8761 aagaactggc tcgaaatctt cttgcatatt tttaccagct attttaacta ttacagcaag
     8821 tggtaatctt aatacaccat ctgcatcaac ttcatctata tttggtccta ttatttctat
     8881 cttatggtct tcaacttctg ttgcttcttt cttaacaaca agctcccaag cttcagttct
     8941 gtttccacca aactcagcaa acatatcgct ctttctaatt ctctcacctt caaatgctgc
     9001 tgcaaatgaa actgggatag gtatttcagt aacttttatt tttattcctc tagcttctaa
     9061 tgaagtagct actatcttat cgtaatcttt ttgagttaat aggttcattg gaacttcaag
     9121 aactgtttgg tcagttataa ctgggaatcc taaagctatt gctccagcac ctgcagatac
     9181 aactaattca cttaatggtc caaatgcatt aacaaatgca ggaactctat tagctgtgta
     9241 ctctaataat ccgtttaaat caccaggagt taatccaccg aatattaatg ctgctcttac
     9301 tgcaacagat acaacgtgta taacagaagt tacatcatat cctagaggta taactcttag
     9361 ctcaagaccc atttttactc cagcttctat agcttggtct ataactttac caactaagaa
     9421 agttagtaaa cctttagatt ggtaatcttt tataactttt gctgctgatt ctgcatctgg
     9481 acactcacca agaacaactg caacaccagg tatatctcct gtaactaatg gtacaccaag
     9541 tgatctgatt atagggtcag ttatatgacc tgcacatggc tcactatatg gagcatccat
     9601 agttgaatat tttaatgctt caattacttc tgctgctaaa gctgtagcta aaccagcatt
     9661 aaaagcatgt tctagtaaat gagttctatt tattaaagat tttactactt ctaaagcacc
     9721 ttctaagtcc cctaaagtgt tcatcttttg tcctgttgca gcatatatac aaggtaatga
     9781 atatgctgta tcagggaaag caactttatg ctcttttcca ttcttttcta tagcttcagc
     9841 taacatagct tgagccgcac ctaaagcttg ttctgaccct gtaaagatta tattatatag
     9901 attcattcta tttccccctt taatatttac acctattttt tattaactat accctaaaaa
     9961 ccctagaaag caaatccacc ttcatttaac tctaagaaag agtctgcata taaagatgcc
    10021 ccgttgatta tgtcacaaga ttttacagtt ttcattaatt ctgggtcaca tggattcatt
    10081 atagctgaac taaatccatt agccattgcc attgctaaga atgcactatc taaaacaggt
    10141 ctaacatgct taggacatcc attagatacg ttagataatc ctcctgtagt taaaagtccc
    10201 atctcagtca tcatttttat agcttctaaa acttctactt gtttttcttg catacctttt
    10261 ataactaagc ataatgggtc aaatagtata tcagttggct ccattcctaa cattaagcct
    10321 ttttctaata tttcttggca gtaagccata cgctcatcat tatctcttgg gataccttct
    10381 tttgcacata aacctataac cattgcttcg tattcagctg ctatatctat taaatcaaat
    10441 cttgagccag catcagcaga gtttattatt ggttttgcat tagttctatc ataaacttta
    10501 agtccagctt cgatagcttt tttattagct gtatctaatg ctataggaac attgttgaac
    10561 tcagattgaa gtaatttgat tccccatgtc attatttctt cgccatctct ttcggcaggt
    10621 cctatattaa aatctatata gtgtgctcct gcttctaatt gctcttttgc tctttttaag
    10681 attggagctg ggtctctttc tgctaatgct tttcttattg aaggtgatat acaatgtatt
    10741 ctctcaccta taatcataaa tttttccatt tataatgtcc ccctttaaat ttaatattaa
    10801 tagttagtta atattttatt agtttgtttg gcatgctttt tcttggtatc cttttaagaa
    10861 cttaggtaat tccatagatt cctctggtcc tataactaca ttccatcctg gtaagttatc
    10921 ttctatatca cctttaagta ctgcaacttt tcctggaatg ataaggtctt tacaattagt
    10981 tacttcttct accttacttt ctttaatgaa agcagagatt gagtttccac caaatttacc
    11041 agcagcccaa gatgtaagaa ctgaatatcc acctgcatct ggtattacta accatactgg
    11101 aacttttgat ctttctatat caccagcaac tatgaagtaa gttaatgcaa agtcaacagt
    11161 aactaatact ggagaatttt catctgggtt gttgattgga taaatctttg gttcaactct
    11221 cattggtctt tgtgggtcag tgtatatgtt ttgtcttagt gcaaataatg gtaatgcctt
    11281 agcataacta atatcatcta ttactattat agaaccgtat tttatagtga atattgatga
    11341 taaagcaact tccatcatag gatttgaatt agataatcta tttgcaaata ctattgaagg
    11401 atatccaaat gttctatctt gctcttttaa agctgttctt ctaacttgta tagcattagt
    11461 gtaagtatct tttatgtttt ctcctgttac atctaatact aattctttat atccagcagc
    11521 ttgaattaat tcaactgttt catataattc ttctaagcta ccagctttta cacctaatgg
    11581 taaacttgct cctttaacta cttctatcat atctttgtag ttctctttag ttgctccata
    11641 taccattggt ctagcatctt ttaatacttc aacagcttct ttaactactt gtgcatcatc
    11701 acaagctaaa atataagcta cttctaatcc actgcctttt attttatcta ttaattttaa
    11761 atacgcatct ttatctccac aatactctaa aacagccatt tcaactttca tttgttcacc
    11821 aattcttaca tagtcaactt ttttcatgtt agctatttta gcatctactg cttcatcact
    11881 catacaagta cagaatgaaa ctgcatatct atttctactt actaatgttt tttcatgtct
    11941 aaataatact gtttctccac ctagttcata ctcagatgca ccagcaccaa cttttaaagc
    12001 tttcattaaa ggtgcagtag cctctgataa ttttgctata gcgtcatcag acatatgtgg
    12061 gcatttacct acttctacag ctcctgaagc aaccttcata gagaaagcca tacaagttgg
    12121 gaatccacaa tccttacagt ttttctttgg tgttaattta aatatatcta aagcttttaa
    12181 tgccattatt ttttccccct aaccttaaca atttaattaa gctaatgcgt taaccaattc
    12241 ttttatagtt tctattgatt ttggatgacg aagtataact gcgtttgaac cacctactaa
    12301 aacacttgct gcagttgaaa cttccattgc tatagttctt tcttctggac aaccccaatc
    12361 tggctcatct tctattggag ctatagcttc tttaacatga cctacttcaa aagctactgg
    12421 tgttatgata ggcatttgta atgtcttatc attttgacca aatgctgcaa gtctaattct
    12481 atccatagta gatgcaacgt actcatatcc ataaccaact gctgaacatc caacattcat
    12541 aactatattt tcacctttaa cgcctagttg agttaacaat acgtttaatt gtttagctag
    12601 gtttatatca acagaagatt cagctcctac tttatgtgca taagccatac cagctgatgc
    12661 tcctactcct ttgtagttgt cttctactgc tgacataaat aagcagttat gtccatccaa
    12721 tgtttgagct aatttttcaa ataatttacc atctttttca tgatttcctg aaccagctac
    12781 aactaaaggt aattttattg cttcaattac tgccttagct acatcagcac attcatcaac
    12841 tgacttatct aatccatttg ggtcagaacc atcaaatttt aaacaaataa aatctgcttg
    12901 tgtattagct tcaacatatt tagcccactc tactggacaa ttagctacat ctttgtataa
    12961 ttccttatat gaatcagtcc agctttcagg ataaacgtct gatatttgta tacctatttt
    13021 tggagaatta cctacttctc catcaaaact ataaaaaggt aatacatttt ccccacctaa
    13081 tttaattgct ttttccccta ttcctacttc aacttctgat atttttccag aatatttttg
    13141 agtagacatt ttaaatgcca tatttttttc ccccttaagc ctattttaat tctaatttag
    13201 caaaaatttc tttcatagcc actttagatt ttgaatcttc aggtaaatta actaaaggaa
    13261 tacctgtaga atcatattca tatatcaatt catccatagg tacaacaccg attagctcta
    13321 ggttatgctt ttcaatttct tctttaacac catcattcat aaccccattt ggaactttat
    13381 ttacaatcaa aagtattctt ccaacactta actttagttc ctcagctaaa tctcttattc
    13441 tagcaacagc ttgtatgcta cgtcttgagc aatcactaac caataaaagt gtatcaacat
    13501 gtctagtgac ttttctactt agatgttcca taccagcttc gttgtccatg actaagtatt
    13561 tgtaatgacc agatattttg tttacttgtt ctctaagtat cccatttaca aaacagtaac
    13621 atccttcacc ttctgaccta cccattacta ataagtcata tccttcgcct tcttcgatta
    13681 tagaatttaa tctaaattga agatattgtg cctttgtcat accaccaggg aatgcattgc
    13741 ctaacttttc tctttgattt acttcttctc ttatttctcc tattgttgct tcaacttcga
    13801 tacctaatac ttcatttatg ttagcattgg catcagcatc tacaactaat actggtccct
    13861 ttttgtcctt aaccaaataa tcaatcaaaa gccctgtgag acttgtttta ccagttccac
    13921 cttttcctgc aacagctata ttgtatccca ttttaagact tcccccttaa atctagccac
    13981 agagccttat gtactctgtc tgtctattat aatttaggta cagaatgaac acattctcca
    14041 tgtacatcat gaagtgcttc cattagccct tcagataaac ttggatgtgg atgtattgca
    14101 tcccctactt gttctactgt taatcctaga tgaacagcaa gtgacaactc tgtcaataaa
    14161 tctgtagcat gaggtcctac tactgctgca cctattatct tatcagtttc tttgtcagct
    14221 ataactttta caaatccttg gaaatgtcct atagcttgtg cttttccaag ccctctaaaa
    14281 tcaaattgac ctacattgta ttctacacct tcagcttcaa gttgcttctc agtcttacca
    14341 acaccagcaa cttcaggttc agtataaaca catcttggaa ttgctctata atctactacc
    14401 ttagtcttac ctaaagcatt ttcaactgct acgatacctt ctttagaagc aacatgtgct
    14461 aggaaaggag tatctattat atcgcctatt gcgtatatac cttctacatt agtttcaaga
    14521 tgttcattaa ctactacttt tcctctttcc atttcaattc ctatatcttc tactccagaa
    14581 ttgtcaaggt taggtcttct accaacacat actaatgcat attgtgcttc tataaccttt
    14641 ccattagaaa gagttgcaac agccttacca tcaactactt cacaagtttg tactccaata
    14701 cctgtaataa ccttaatttt atctttctta aattgtctaa gtagttgttt agctacatct
    14761 ttgtcttcat ttaatagtat ttggtcaacc atctcaacta tagttacttc tgttcctaag
    14821 gctctaaaga actgccctat ctcacatcct ataactccac cacctactat taacatagac
    14881 tcaggtatct cttcaagtcc aagaacttca tcactagtta ttacaacttt tccatcatat
    14941 gggaacattc ttggtacaac tggaacagaa ccatttgcta gtattatctt atctgctttt
    15001 atagtttcta ctgttccatc atctttagtt acttctatag tgtttttatc aattaatttt
    15061 ccaaaaccat taactaggtt tactcctctt ttttcaaata agaactctat accacttatt
    15121 aattggttta caactttatt ttttctttcc attatggcag tgaagtttgg cttaactgta
    15181 ccatctattt ctataccaaa atcctttgct tcttttacag tattcaatac tcctgaagaa
    15241 gcaagaagtg ctttagttgg tatacatcct gcatttaagc aagttcctcc aactcttctt
    15301 ttttcaacaa ctgttacatc tgcaccaagc atagaagctt ttatagctgc tacatatcct
    15361 cctggtccac cacctactac tactatcttc atctttaatt cccccaaacc taatataatc
    15421 tacaatcttg caatactata aacctgcggc atccagtata gcaggtatat tctcttctgc
    15481 cccaattgcc attatatgaa caccatcaca taaatcttct tcttttaatt gtttgataag
    15541 ttcccctgcc atttttattc cttcacttac ccagttttct tttccagctg ctcttaatct
    15601 ttcgatttgt tcatctggaa caaatattcc tggtacattt gcagtcataa atttagccat
    15661 tcctggtgat tttaaaggta ctattcctgc taataccttg caatccatat cccttgttaa
    15721 ttctctaaac tttctcattg tatttatgtc ataaagtgct tgtgtttgga aaaatttagc
    15781 ccctgctttt attttctttt tcatttttaa taattgaact tctattggag aatattctgg
    15841 agttactgat gctcctagat aaaaatctgg agaacctttt aacttattac cagccatgtc
    15901 cgtacctgcc attaaagtct cagcagtttg aagtatcccc acagaatcta aatcaaacac
    15961 tcccttagct tgtggatggt ctcctacgct agtatggtct cctgttagtg ccaacagatt
    16021 gtttatccca aatacacctg ctgacaacat ttctccttgt atagctattc tatttctatc
    16081 tctccctgtt atttgaataa ctggctctaa tccagcatct tttaataatt tacatgtagc
    16141 aagagaagtt gctctcataa ctgccgattg aaagtctgtt acatttgctg catgaactct
    16201 tccaactaac ggctttgcac attctattaa atgtgaaagg tcagtccctt ttggaggagc
    16261 catttcagta gtaactgcaa attttccact ttctaatgtt tctcttaata agctcatctc
    16321 taatccccct tttaaccttc taaaaaaaac ttttatgaat ttgctgctgc ttctttcttt
    16381 ttctttgcac ttaaacttct tggattattt tgcttagaat agtcttttgg tggtcttatt
    16441 tctgctaagt tatctaattg tcctatagct tctagtcttt catatatctt tatccaagca
    16501 caatcattct ctgagtttac ttcacactta ccatttttag ctccaccaca agccccattc
    16561 ataagacctt tagcacacat agttactgga catatcccac ctgtccaacc aagttcacag
    16621 tctccacaag ccttacaggc ttcttcatat tctccaactc tttgtacttc ccctataaac
    16681 aaagtattgt tggctggata aactggctta tcttttaaat tcttaactat tgtctgtgta
    16741 ccatctccac atgctaaaga taaaactgca tcagcttcct tagtctcttc ttttagagcc
    16801 tttaaatcct ttttagactt taaaaggtta caagcagggt caagcattac atatcctaag
    16861 atttttttgc cttcaccttc aagagtttcc ttcattttta aaacttcttc ttccccacca
    16921 cttttacaag ttgctgcaca ttgattacaa ccaactaaaa ccagcttgtc aaaatccttt
    16981 aagtacccta gcacttcttc taatggttta ttttcagaaa ttatcatatc tacttccccc
    17041 ctaaaccttc cacatatata tctatttatt gttttgtaat ttacaagcct taactacatg
    17101 ttttgcaagt atagatgttg taactgaacc aacccccgct ggaactggag ttatcattga
    17161 tactttgtct aaaactgcat ttgtatcaac atctccacat aaatttcctt cttcatcaac
    17221 atttatacca acgtctataa ctaccgctcc atctttaaca aaactttcat caaccatctt
    17281 agctctacca atagctgcta ttagcacgtc tgcctctgct gctacacctg atagattttt
    17341 agtttttgaa tgacatattg taacagttgc atgttcactt aataaaagca ttgatactgg
    17401 ctttccaact accattgatc ttccaagaac tgttacctta cttcctttta aatcaacatt
    17461 atagtgtttt aatatctcaa ctactgctgt aggtgtacat ggtggaaatc cacttttatc
    17521 cccttccatt accttagcag agtttattgg actaaaacaa tctacgtctt tttccggtgc
    17581 aataacatat tttataactt cttcatttaa gtgttttgga agaggtctaa aacataatat
    17641 accattaaca tttttgtcat cattaactct ctttaataca tcaatatatt cctcttgtgt
    17701 tatatcctca gctaactcta acacttctgt tgttatacct atgttttgac atctctttag
    17761 tgctcctctt tcataagata aatcatcact tcttgcccca actctaacta ttgttagttt
    17821 aggatttata ccttctttaa ctagtaaatc gacttctttt attaattctt cactaatctt
    17881 atcagctaca ggttttcctt ttataatttg tcctttagtt gacattcctt ccatacattc
    17941 acaactcccc tacaagcaaa cttaaattaa tttattctat ataccacata ttaataacat
    18001 agtatctact ttcgtcattt aaaaattatt ttccaagagc tttttcaact ttggcataaa
    18061 cttcatcaca aatttttaca ccatcttcaa ctaacttatc tacttctgtt tttaccttat
    18121 taacatattc tttatcttgt atagaattta tatttataac tacatttaat tgtccaccaa
    18181 gtatagcagc tcttaaacac tgaactccta caccaacatc acttatagca agtcttgaac
    18241 ctttatcaac taaatcttca tgtaacttaa tagcttcata gcaaactctt actatgttta
    18301 atggtacttc acaagcaact tttaatgcct tttccattgt ttctgctttt attctttttt
    18361 cttcttctgt ttctttagga agcccgtaag cttttgataa tggtaagaaa cattctgcat
    18421 catcatctat catttttaat aaatcttttt ctaactttcc tgccttactt aatatctctt
    18481 ttacactttc ttcatactca gcatacttct tcttccctat tgtaaggtta cataccatac
    18541 tacctaaagc catacctatt gcacctacta gtgcagcagc tcccccacca cctggtactg
    18601 cttctttgga agatagtact tctacaaaat caacacaagt tttatctgct attttcatga
    18661 taatcctcct tgaaaggatg taggaaaata tctcaaattg ttcgagatat tttacgaact
    18721 attttaagat atctcctact ctttatttat aaattaattt ccttagaata atccagctat
    18781 tactccattt tcatcaacat ctattttttc tgctgctgga acttttggta atcctggcat
    18841 cttcattatt tctccagtaa gtgcaactat aaatccagct cctgctgaaa ttgttgcttg
    18901 tcttacagtt attctaaatc ctgttggtct acctaattta gtttggtcat cagttaaaga
    18961 atattgagtc ttagccatac atactggaac tttagtaaat ccaagttttt ctaagttagc
    19021 tatttcctta tcagcttcag gagtataatc tacaccatct gctccataaa tcttagtagc
    19081 tatagcattt atcttgtctt ttatagataa atcatcttca tagcagaatc taaagttatt
    19141 ttcttcttca tccaataatc ttaaaacttc tttagctact gcaattccac cttctccacc
    19201 ttttgcccat acttcagaaa gagcaacatt aacacctaat tccttacact tgtcttcaac
    19261 aagtttaagt tcagcttcag tatcaagtgg gaatctattg attgcaacaa ctgctggtaa
    19321 tccatatact tgagttatgt tttcaacatg ttttaataag tttggaagtc ctttttcaag
    19381 agcttctagg ttttcgttat ttaagtctgc tttagcaact ccaccattgt attttaatgc
    19441 tcttacagta gcaactatta taacagcatc tggttttaag tttgccattc tacattttat
    19501 atctaagaat ttttctgctc caaggtcagc accgaaacca gcctcagtta ttacataatc
    19561 tgcaaagtgc atagccattc ttgtagctat aacagagtta catccatgag ctatatttgc
    19621 gaatggtcca ccgtgtacaa atgatggtgt tccttcaaga gtttgaacta ggtttggttt
    19681 taaagcatct tttaataatg cagccatagc accattagct tttaattgtc tagctgttac
    19741 aggttcacct tcgtagctgt atccaactat tatgtttcct aatctttctt ttaaatcaga
    19801 tatatcactt gccaaacaga atgctgccat tatttcagaa gcaacagtta tatcgaatcc
    19861 atcttgtcta actgctccat cacctttttt acccatacca tcaacgatat ttctaagttg
    19921 tctatcgttc atgtctacac atcttctcca agttattttc ttagggtcta ttctaagtgc
    19981 atttccttgg tgaatatggt tatcaagcat agcagctaaa agattgttag cagctcctat
    20041 agcgtgaaaa tctcctgtga agtgtaagtt tatatcttcc ataggaacaa cttgtgcata
    20101 tcctccacca gctgctccac ctttaacacc aaatactggt cctagagatg gttctcttaa
    20161 agcaactaat acatttttgt ctagtttagc aaatgcatca gcaacaccta tagtagtagt
    20221 agtttttcct tcacctgctg gagttgggtt tatagctgta gttagtatta acttagcttt
    20281 tttaccagtc tctcttttta gtagattgta gtcaactttt gctttgtatt taccataaag
    20341 ttctacatca tcttcaccta gtcctaattt ttttgcaacc tctctaatat cttgaggctt
    20401 agcttcttga gctatttcaa tgtcagattt aaatcccata actgaatctc ctcccacaac
    20461 ctaaatagat ttaaaatata atttttgtaa aaattgtatt aatatgtaaa aattatattt
    20521 tataagataa ttatacatgt aaaattactt aaaaactagc tactaagcta ttaaaatatt
    20581 caaacttaat agctagttat ttatctaatt acttacttat tacctatcta ttgcctatgt
    20641 ctaaccttta accaacttaa aatcccaaat caaaatttct atctatttta tttatcctta
    20701 agtgacatta atttatcttt tattgcttta atctgttctt tcgttgtttc actagaatca
    20761 tatggagatt gattagctct atcagaatca ataacatctt ggttataata aataaatcct
    20821 aaagattctc catcttctaa gttttggatt ataaattctt catcttcctt atttctaatt
    20881 ttatttccta ctacaaatac tttatttaca cctatatcat gtccaagttt cttaactttt
    20941 ctataagtct gtagacttct ctctcctggt tctacaacta ctataaaagc atctacacct
    21001 tgggctgttc ctcttcctaa gtgttcaatt cccgcttcca tatccataac cactacatct
    21061 ttattttgta gtattaaatg tgagcagagt ctcttcaaaa gaacatgctc tggacataca
    21121 catccagtac caccagaatc tacggttccc aatgtaagta atcttactcc attgtattct
    21181 ttacagaaat tttcagggat atcgtctact ttaggattca tcttaaacat ttttccaaat
    21241 gaacctacag aagcagctgt tctatctgaa actaattttt tcatttctga tataggtact
    21301 attgattcat atacttcttt tggaaaacct agtgctaaag ctaaattagc atcagggtcg
    21361 gcatcaacag caacaactct gtatccgtct tcagcaaaca tcctagagag cattgaagaa
    21421 aaagtcgttt tacctactcc acctttacct gttattgcta tcttcataat ccctaccacc
    21481 ttttattact atttgctttt tagtagttaa ttttacagtt aaatattttt tatactctat
    21541 atttttatac actaaaaata aactacagct agtccttaca ggaaccaatt aaatttaccc
    21601 tactagcttt tcaaagcagc atgtatagtt ttattattct ttaatattgt ttatatttta
    21661 tttattcagt atattcatta tattttgatg ttctttactt taatatttga ctttattcaa
    21721 ctttattcaa ccagaaactt cttataaaaa cgtttattct ataacttcac tattttttaa
    21781 gcttcagcct tttctgtcat tttttcttca actaatgctt caaagtgaac acgttttttc
    21841 tctatatctt ctattattgt agctgctaac tcttttggat ttgtatttac agtaaatgta
    21901 gctccaactt tatcttttaa ttcactagtt aatatatcca ctgctcttga agaaccagct
    21961 attggaggca ttattcctaa ataagtgtct ataccagaag ctacaacata gcatcctata
    22021 gcaactgctt tttctgacat ccactctgga gctataccta caactggaag gtcacacata
    22081 tccatatcta agtaattagc tgctgctcca actaaatcta gtatacggct tatatcaaca
    22141 caagaaccca tatgtagtac tggtgggatt cctactaatt tacagacagt tgcaagacct
    22201 ttacctgcat atttttcagc cgcatcagat tccattaaac caaacttagc tgctgctgaa
    22261 gctccacaac ctgtagtaac tactattatg tcgtttttga ttaattcttt cattattgtt
    22321 acgtgagcct catttgaaac tcctttagca ttgttacatc caactacacc agctgctcct
    22381 cttaatactc cagcttttag acagtctgtt aatggcttaa ctgttcctgc tgggtctata
    22441 tgagagttta caactctgtc taattgattt actactgctt ctacactata cccaactgtt
    22501 gcccctgatt ttaattcagg tataagtact tttgatttat ctctattttt aaagtttaaa
    22561 atagcttctt taactattgc tttagcatca tcaagtgctt gttcttctct aaattcaata
    22621 taagttgaac ctgttatctt agcttttgga gaagttgtta caaatttagt atggtaacaa
    22681 tctgcaactc tagctaatgc agggaatata cattgaacgt caactattac agcttcaact
    22741 gctccagtta ttattgcaag ttcttgttga tggaagtctc ctgctatttt tacaccatgt
    22801 ctcattgtaa tctcattacc tgtacaacac atacctgcta agtttattcc atcagcacca
    22861 acttctttag ctaaagctac taagtctggc tcttctgatg ctaaaactat catttctgat
    22921 aatgctggct catgtccatg taatattatg ttaactttat tttcttctaa tactgctaaa
    22981 ttcgcctctg ttcttcttgg cactggagtt ccaaataaga tatcgcttag acgagtacct
    23041 atcatagaac caccccaacc atcagccata gaagttctaa gactcatgtg tattaaacta
    23101 tctatatcac cagtacatcc tatatgagta gagtgcatta ttgttgcaat ttctctatct
    23161 atagctcttg gctctatagc gtattctttc catatttttt gtcttggttc tggtgcattt
    23221 tttataaatc ttaatgtccc aaaaggtttt ccaaattcca ttaatgcaat ttctgccact
    23281 tcatgtgcta catcatagat atctctacct tctgtctcta catcccattc tttagctaaa
    23341 gtaattaact tagcttcgtc tcttatttta tagtttccat ttggatcagc taatgctaat
    23401 gtatgtgcta tatctctagc atggtctgaa tgggcagctg tcccaccagc aaccattctt
    23461 gcaaagtttc tacctactat agtatgctca tctgctccac ataaccccct tggagtctta
    23521 gggcttattc tacatggtcc cattccacat attctacagc aaacaccttg aagaccaaaa
    23581 ccacattgtg ccttaaagcc ttcttttcta tcatacattg tttctacgcc ttcttctcta
    23641 gctttagcta tcatcttctg gctgtttaaa tcaattgtta acattttttc atccatattc
    23701 ctatcccctt tttttgattt ttaaaatccc ccaggtgact gacttcatgt cataaaataa
    23761 taaaataaat gctttctaag ttgattatat actaattttc agtgctttgc tttagattta
    23821 aatatttttt taacaaaatt agataataca taaaaatttt attttctaca cttaatttaa
    23881 gttgatttta tcgcttgttt ttggctattt gttaatatct aaacctactt ttttgatact
    23941 tcagtttaat taaattatgt tttgattttt ttaaatcaaa tttgaaattt ttctagtcat
    24001 ttttatatta ttgcagattg tttgtgtatt tattatcttt cactactgtt tggacttatt
    24061 acagattttt actccctaaa cttaattagt aaaaacttct tagaatagca ttttttggac
    24121 taattttttt gaattttttt atttttccta ctttaatatt aattatagct tcaaattgaa
    24181 catttgtata tattcatttg aagctataat tattttttat ataaaacttt tttaatacag
    24241 cattaattta gacattttga ctattttttc tactttaatt catttatttc aagcgattta
    24301 tcctatttca tatttttagc tacaatagcc ccatatgcaa tagaatataa tttagattca
    24361 tgtgaatcag ctcttgacac taaaactata ggagcttttg cacccataat tatacctgct
    24421 gatttagagt ctgccatata tgtaaaggct ttccctattc cattaccaac ctctattgtt
    24481 ggaaccaata tgatatctac atctccagat acttcacttt taaacccttt tatctcacta
    24541 gcttcttttg aaacagctaa atcaaaagcc agaggacctt ctacaattac attttcacca
    24601 aattctcctt ctttacaagc ttttgctaac atatctgcat ctacagttgc ttgcatctta
    24661 ggatttactt tctctttagc tgccaaacat gcaactttta cagtttccat tcctaaagct
    24721 tttgcagctt ttatagaatt ttttaatatc tttgcctttt gttcataatc aggagctata
    24781 ttcatacctc catctgtagt tataagtaat ttatggtatt tttctaactc atataccata
    24841 acatgactta ataaactatc agttctaaga ccatagtctt tatttaacac ttcttttaat
    24901 atgacagatg tatctaataa tcctttcatt acaaagtcag cttctttact tgatactaat
    24961 ttaactgcta tttctgcaca ctctttgata tcatccttat ccactatttt gataccactt
    25021 aaatcaaatc ctatttcttt tgatatttct cttattttgc cttcatttcc aaccaatata
    25081 ggagtaatta tatttctttc tacagcatcc tttattgcca ttaaaacttc tttatcatga
    25141 gctgctgcta cagagagtac aattttctct cctcccttaa gttgttctaa aatatcatct
    25201 aattttttta tcaaaagtaa cccctccctt atatatattt aactaaataa taccatattt
    25261 gctatacctt ttctcaattt attttttatg ttataaagaa tttatataac taaaagacag
    25321 tttaatattt tattctggga tttcatcaat aactcttaaa agctttgcag gaacaccacc
    25381 tacaatagta ttttctgcaa cattttttgt tacaactgct ccagcagcga taattacatt
    25441 atctccaata gtaactcctg gaactatagt tacattagca ccaatccata cattttttcc
    25501 tattgtgatt ggagaaggat aagttgtacc acgtttctct ggtgcaatac catggttaag
    25561 tgtagccaat accacattat gcccaatttg cgtattatct ccaatatcaa tccccccctg
    25621 gtcttgaaaa tggcaactgc tatttataaa aacatttttt cctattgtga tgttttttcc
    25681 acaatctgta taaaatggtg gaaacataaa aaatgattca tctacctttt ttccaattaa
    25741 ctcagaaaat aaactacgga cttcttctgg ttcatgataa gaagaattta acttacttgt
    25801 gattttcatt gcttcattac tcaacttaac cataaattca tgtatttctg atttactaga
    25861 aacaggtttt ctttgattga tatgtgttaa aaattcattg atattcattt tatacatcct
    25921 ttcaatatgt gctttaattt atttgtacat tctaaataat attttaataa aaattaattt
    25981 aatttatttt tattaaaat
//
LOCUS       DAEQCW010000050        25768 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.050, whole genome shotgun sequence.
ACCESSION   DAEQCW010000050 DAEQCW010000000
VERSION     DAEQCW010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25768)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25768)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25768
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.050"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..380)
                     /locus_tag="KRO40_002067"
     CDS             complement(<1..380)
                     /locus_tag="KRO40_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="HBH2092886.1"
                     /translation="MREIKWKLNNLPKSEEKEKGIEFLKDEEIAKAKAFHESFPQYEK
                     TPLVKLDNLAKSLGVSGIYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLNTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGN"
     gene            complement(994..1532)
                     /locus_tag="KRO40_002068"
                     /pseudo
     CDS             complement(994..1532)
                     /locus_tag="KRO40_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427977.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="2'-5' RNA ligase family protein"
     gene            complement(1609..3414)
                     /locus_tag="KRO40_002069"
     CDS             complement(1609..3414)
                     /locus_tag="KRO40_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092887.1"
                     /translation="MLSKLKEFQQEMIKYTETVASVLDVDIEIVDDRLIRISGTGLYK
                     SKINESVVTEGFIYDNVIQTGQELVVLDICDNQLCIECSHYMKCLNKVIIAVPIKYNN
                     RTIGVIGAISTDKTKKVEISAKIDNYLKFVNHICDLISMKIEEHEASKNSSRKMDMMI
                     EIIENVEKGVIILDINSKISYINNIALKKLDIDKNIIENIVNIVSVESSSNGHELLEI
                     DIDNKIYNINAKIIPVYPYINQYDKIIIFDKTYINHKGHGKVNSGWGNSDIESIIGNS
                     EAMLKVKERTKKLAKSNSTVLITGESGTGKELIARAIHAEGSRWNKPFIAINCAAIPE
                     NLLESELFGYIKGAFSGASSGGKVGKFELANEGVIFLDEIGDLSMPLQAKLLRVLQER
                     KFARIGSNKLIDLDIRVIAATNKNLLKLVNEGKFRDDLYYRLNVIPINLPPLRERKDD
                     IEAIMMKFASKYSLELGIQLNKIEENVMNMLINYNWPGNIRELENAVEYMMNLVGDDG
                     IIYKDMLPLDILNYYNINGNIYKNKDVNIIFEDDIVGGIVENQERILSIKELELTYIN
                     KLLNKYGRDTKTKKKIAKDLGIGLATLYRKLEEEQ"
     gene            complement(3810..4187)
                     /locus_tag="KRO40_002070"
     CDS             complement(3810..4187)
                     /locus_tag="KRO40_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH2092888.1"
                     /translation="MSKVVIATEKAPGAIGPYSQAIQVGNIVSTSGQLPIDMKTGELV
                     SDPKEATKASLDNVKAILEQAGTSMDKIFKTTVFVKDLKDFNDINEVYATYFKENPPA
                     RSCVQVAQLPKDAVLEIEAMAVL"
     gene            5092..5577
                     /locus_tag="KRO40_002071"
     CDS             5092..5577
                     /locus_tag="KRO40_002071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092889.1"
                     /translation="MSKSELTAETTEEMLEVLSGKDYDIACHLHELGKSLDCKIEPKT
                     GARSYKIVYSTKKPKRSLFTIECNEKKWRVKANLFHLNTYKDAVEECSKTIKDSITKT
                     RTCKKCNSKCIGGSSFELDGKSYLTCIGSGHYFANMEEMDWKNLEKLITKENNIMQES
                     V"
     gene            complement(5777..6316)
                     /locus_tag="KRO40_002072"
     CDS             complement(5777..6316)
                     /locus_tag="KRO40_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2092890.1"
                     /translation="MSKNVLIVSASPRKGGNSDLLCDQFIQGVLESKNQVEKIFLKDK
                     DINYCTGCGACYEKEANCSQTDDMGEILEKMIGADVIVLATPVYFYTMNAQMKTMIDR
                     TCSRYTEICDKDFYFIVTAADENVADMERTIEGFRGFTSCLNGSKEKGIVYGVGAWNV
                     GDIKGSKAMKQAYEMGKLA"
     gene            complement(6309..6722)
                     /locus_tag="KRO40_002073"
     CDS             complement(6309..6722)
                     /locus_tag="KRO40_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2092891.1"
                     /translation="MTISEVSKKYELSADTLRYYERIGLIPPVNRNKSGIRSFTEEDC
                     EWVNFIKCMRGAGLSIETLIEYVAMFQQGSSTIKARKELLIEQRNQLAKRIEEMQKTL
                     ERLNFKIDRYEEGIIEKEKVLKSSRNKKMEAVSYE"
     gene            complement(6758..7879)
                     /locus_tag="KRO40_002074"
     CDS             complement(6758..7879)
                     /locus_tag="KRO40_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH2092892.1"
                     /translation="MEAKKLGFGLMRLPIKDENDVTTIDMEHLNKMVDTFLERGFTYF
                     DTAYVYHMGKSEIALRESLVKRHKRESFTIATKLPLMALKKKEEQETIFNEQLEKCGV
                     DYFDYYLLHNIGVSHYEVAKKFDSFKFIEEKKKEGKIKNIGFSFHDSAELLDKVLSEH
                     PEVDFVQLQINYLDWDNESIQSRKCYEVAEKHNKPVIVMEPVKGGTLAKIPEKAEKLL
                     NDYNPDMSISSWAIRFAASKDNVMMVLSGMSNMEQLLDNTGYMQNFKPFVQEEYNIID
                     EAVEIINESILIPCTACQYCVEGCPKNIAIPNYFALYNAEKQALNTGFSTQMVYYNNY
                     TKTYGKASDCIECKQCEESCPQHIKIIDALKNVAETFEK"
     gene            8478..10130
                     /locus_tag="KRO40_002075"
     CDS             8478..10130
                     /locus_tag="KRO40_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp21"
                     /protein_id="HBH2092893.1"
                     /translation="MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVE
                     VSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAPILLVNNNSIENSTKAELKRLGV
                     DNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKVENVAVV
                     NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSD
                     NTVKKYPNRERISGSDRNNTNAKIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGV
                     LAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAFEDILKLKNVNIRNK
                     TKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIE
                     IEKDDDLNDNNLGTQNISLDKAKSIALDAIPNGNLIYCKYDAEDNEYEAKVIKNKKTY
                     ELEISAFDGRIVDIDMDNDSDDDFDDNDKNNSNTNDNSSIISAEKAKSIMLDKVPGGK
                     IVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD"
     gene            complement(10489..11415)
                     /locus_tag="KRO40_002076"
     CDS             complement(10489..11415)
                     /locus_tag="KRO40_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBH2092894.1"
                     /translation="MSNSFYQLNSAVLYFNEKRDVNRIRFNHYVMRKENIQRLKGTLP
                     RGQFMMTVRKAASDLDVSISTISRLVNEFIDLGILRLISRGVKGNCCSVYSYVCSESS
                     NAEIVTKNGDIFKNIEKYIDATINNNQKTMKYKHRNELFKNSNTNIYSRINQESIDKD
                     YDLIIHTGYETENETKKKELLKNNLNKKNLNKNTFENSDEDLTEDSTYKNPESIHEII
                     IRKLNSESGKNFKADLSITKALIDKRLKEGYSLEDFYKVIEAKVRRWRYTDMEIYIEP
                     TILFGYEFESYLNEESSLSACNYGDMCYEDMY"
     gene            12005..12925
                     /locus_tag="KRO40_002077"
     CDS             12005..12925
                     /locus_tag="KRO40_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2092895.1"
                     /translation="MTNAKSKKEYLNRICKVQDYIEEHLHEPLSLDELSNIAGFSKFH
                     FHRIFKAIEKETLAQYVNRLKLENATAFLIHRTDMTVTDIAHYFGFTDSAVFSRAFKN
                     YYKISPIKYRNNYSKNCKEPYKISQYNRSISKPKCKNTREVKGEIEILELDNMNTIYT
                     RYTGSYGNLTSTFPKLLERLFTYASEQNLLGLENTQILAIYHDNPQFTQEHQLRTSIC
                     MTIPDNIVVKENDNLGNMIIPSGKYLVGHFDISKSEYSDAWDFMYNEWLSNGNYKLRA
                     SFPFEVYLNNPHNHPQNRHLVDIYLPIEPF"
     gene            13011..15431
                     /locus_tag="KRO40_002078"
     CDS             13011..15431
                     /locus_tag="KRO40_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH2092896.1"
                     /translation="MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDI
                     VFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIAVQQNIIRQSNPRSTVGTRTNIL
                     NMLTLLYSVEGQIMCTMCDTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH
                     GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNE
                     VLYGHYENGKKSSSLSKVFHNRYKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGK
                     HIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHLIESRLGHLSLYREM
                     STLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSLKKLKDLGNTVI
                     VVEHDKNTIEMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPN
                     RTSNKNITHTDKIPCITIQNANTNNLKNVTVSLPLGAMVGISGKSGSGKSSLISDTLL
                     PLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEISQSPIGK
                     NMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAGHFSFNSKGACPKCSGSGYEKVWLG
                     NNLSIDHICSECQGKRFNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNV
                     LEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNGNILYVLDEPTTGLSLYDTSK
                     LIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENP
                     KSITGRYL"
     gene            15431..16453
                     /locus_tag="KRO40_002079"
     CDS             15431..16453
                     /locus_tag="KRO40_002079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HBH2092897.1"
                     /translation="MNKNNCLDLIFEKVDPSSVGMSSEKLSQLEPLIISQYSNINGII
                     IARKGKIVFEKYYNGYNADDTFHVASVTKSIISALIGIAIDKGYIKDVDQKVVDFFPE
                     YTCSPSEICKKAVTIRHLLTMTAPYPFKNMTESLERLCKQKDWIKYTLNQLGQKGEIG
                     TFKYSSAGTHLLSAIITKTTGKSAREFANEYLFKPIGMKVIPDYDMKDFGFEDFFGKN
                     LKGWAKDRQGYSIGGWGLTLSARDMLRFGFLYLNDGIWNNKRIISKSWIEESVKMNSN
                     EYGYLWWLCKKDGVLWYSAMGTGGNAICCIPQYDLVIAIPSKIVFKPRDRWEFIEKYI
                     LTSIID"
     gene            16606..17352
                     /locus_tag="KRO40_002080"
     CDS             16606..17352
                     /locus_tag="KRO40_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2092898.1"
                     /translation="MDTYTTSEVADLIGVHPNTVRLYEELNLIPKPKRNTNGYRIFND
                     FHIEQFRFARTALKIEVVQRGLRKDALEIVRTSANRDFDKAISLVNQYLQQLEIEKSN
                     AEEALTIVAQILNGNTPETNKLFLTRKETAEHLNVTIDTLRNWEMNGLLKVKRKQNGY
                     RVYTDEDIKRLKIISALRCANYSLSAILRMLNALSSSPNTNIKTVLDTPKDDDEIISV
                     CDKLITSLKEAEHNAKTMKSHLQIMKKQFS"
     gene            17438..18688
                     /gene="cme"
                     /locus_tag="KRO40_002081"
     CDS             17438..18688
                     /gene="cme"
                     /locus_tag="KRO40_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter Cme"
                     /protein_id="HBH2092899.1"
                     /translation="MENKNTNSTWKKKVILFLASQYISLFGSSLVQMAMIWYVTLQTS
                     SGVWVTVLTVCSFIPQMIISFFAGVWADYYNRKVLIIVSDSTIAISTLVLILFMMSSN
                     GTTSELIAISVISVIRSLGSGVQTPAVNAMIPQLVPEEHLMRFNGINSSLQSIVQFIV
                     PIVAAAILGFGNKINQVLLIDVFTAIIAIVLLIFIKIPKHDIPKQTEKVSFFADMVSG
                     IKYCFSDKFIRKVLFTYGAFMLLCVPSGFLIGLLIERTFGKGYIYLSIIEMIGFLGMV
                     LGGLIIGVFGGFKNRNKTFFLAILSYAIFSIILGLVTQAWQFFIFMFFTNFSIPIIQA
                     SAMTMLQEHVAPQMLGRVLSLPIIIYTGFIPLGMMIFGPMADVISINNLIIIAGIILL
                     FFALAIPYSKQFYKQGISKSNESE"
     gene            complement(19205..20218)
                     /locus_tag="KRO40_002082"
     CDS             complement(19205..20218)
                     /locus_tag="KRO40_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092900.1"
                     /translation="MIGLRYQLKSIKKDKMCIISFFLPVVMAILINFMGTIDISSLGE
                     IRFGIVKDTLPVQTEQWLKKYGMVSVYDTKMHLIREIKDIKTDTIGVVRDGKGIKTVF
                     YGNEINAIKNVGKTLPEMFRLKGDLKDVEVTILPKDSILKEFQNVFIAMILITAMFMG
                     CTFNAMNIISEKEDGISFINEVLPQSRSQYIIQKVFLGLLCGCLSSMITVFICLDISI
                     LDMIMMLLLVVFSAFISSLIGLFIGKLSEGLMVGIVYIKIVMILFIGTPLLIYLLGVN
                     TSGIGNLCYIMPSVATFNGIMEIINGNVIIIKDIVILAVHCVVWFMIYIILDKKRKLS
                     FSR"
     gene            complement(20221..21249)
                     /locus_tag="KRO40_002083"
     CDS             complement(20221..21249)
                     /locus_tag="KRO40_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092901.1"
                     /translation="MYSKFFTLVKKDFWMMIYGKFFVLTLGSLILYSCYINFGYVKFM
                     DEDSYHNNVYLYNPENISMSASPLINQVSSIGELKAKLDEDTSAVCIDMSSSKPKVIL
                     HESIKGVDNYRADYALSLLSSEKDHNSKISDNNAIIQINDKDTSEIKQRKDMTCEILF
                     FEIVAIGFLGIASLLFKEKQMGVMRITGILPVKRSLFILSKIFAFFICDLCFTVLLVV
                     FNIGFLEGIKILPQVLVQASILSIIMSLIGIGCSMLLRDFKQFSLIYLVVAVFITTPI
                     FLSANTSFEIDWIKYHPFYHVYSQLKNAFFMNFSKELVYFVVCSLTIIVLFLLVKYIF
                     NKELVREG"
     gene            complement(21249..22094)
                     /locus_tag="KRO40_002084"
     CDS             complement(21249..22094)
                     /locus_tag="KRO40_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092902.1"
                     /translation="MIKVRELKFSYGKDKQILHGLNFEVKEGEIFGFLGPNGSGKSTT
                     QKILNGVLKGYNGHVSIFGKEVKAYTESLYQKIGVLFEFPYLYTNLSAIDNLEYFSSF
                     YPKNQRRDIYELLDLLEFKKEFINKPVSSYSKGMKQRISMARALVSNPKLLFLDEPTS
                     GLDPSGAVLFRKIIEEERKKGTTIFLTTHNMLDADLMCNNVAFIADGKIMVIDKPKNL
                     KMKNSNNKVEVEFVYNGNRDIEIVDIQELESGITFKYDEILSVHSKEPTLEEVFIKYT
                     GRMLV"
     gene            complement(22525..23655)
                     /locus_tag="KRO40_002085"
     CDS             complement(22525..23655)
                     /locus_tag="KRO40_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092903.1"
                     /translation="MNSLRKIIEKLKNVDISNWIKQNFGLYSVRKKVFLLSKLSGALI
                     ILFYLVVEEFSINSKFEFWIWFIILVIFIMSIDFLLGKFISEPITSINKSAKSMSQLD
                     FSNPCTVNTNDEFGELSRSLNTMSTNLQQALSDLESANIQLEKDVNKERMLLEQRKEL
                     VDTISHEMKTPLGIIRAYTEGLIDEVDEEKKKNYMNVIIEETDRMNNMIVSLLDLSAL
                     EAGVSKLNPERFDFIEFVETVAGRLLIDIPDANFYFTYDLPEYEVFVVADKMRMEQVV
                     ENLVINAKKHVVYNGNLDLSITCENGLLLFEIYNDGRFIEQDEISKIWSKFYRSVQSQ
                     RTGGSGLGLAIVSQILTMQGLEYGVNNRDRGVEFYFMIPIDE"
     gene            complement(23652..24323)
                     /locus_tag="KRO40_002086"
     CDS             complement(23652..24323)
                     /locus_tag="KRO40_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092904.1"
                     /translation="MAKILVVEDEKRMQNIIVEYMQKGGYTCITADDGVEALTILKSN
                     NIDLMILDIMMPYLDGFSVCRVSREMTNIPIIILTAKGEEEDKLKGYEYGADDYITKP
                     FSPKVLLAKVNALLRRYTTDIPKNSLSLGKIFIMVASRQVYVEDKLIDLTYKEFELLR
                     LFMENPNQVFSREKLLNCIWGYDFEGNTRTVDTHIKTLRKKLGSEGHHIVTLIRSGYK
                     FEVKE"
     gene            complement(24526..25176)
                     /locus_tag="KRO40_002087"
     CDS             complement(24526..25176)
                     /locus_tag="KRO40_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBH2092905.1"
                     /translation="MDFISSILQGLLSILFNFTGDFGISIVLITLIVKLVLMPLSLKQ
                     RFSVKKQQELAEKMEYIKEKYKNDTKELEKQIQVSSVESMKSMLGCLIVLVQMPVVYA
                     LYHVCLDMTKEFTTIIIPWIANLGTFDNLFILPCIYTLIMLASNLVNYIPYLKINSQV
                     KFNKQMAVVTTITSLILTVRTPVAIGLYFITSAIYSLIEDICFRIYFNRKNRIVTK"
BASE COUNT         9088 a         4078 c         3116 g         9486 t
ORIGIN      
        1 tgatttccat ctgtggctgt aaagaaagtt atttctccta atttttcttt tatttctttt
       61 gaagttaatt tatcataccc taactcagat atatctgtat ttaatctttg agctaagtat
      121 ctacccatag agtaagaacc acctaaaact ttaaatgcat ttaaaccaaa tctataagat
      181 tcgtctttaa catatattcc gcttacgcct agtgattttg ctaagttatc taatttaact
      241 aaaggagtct tttcatattg tggaaagctt tcatgaaaag ctttagcctt tgcaatctct
      301 tcatctttta aaaattcaat tcctttttct ttttcctctg atttaggtaa gttatttaat
      361 ttccatttta tttctctcat ttattttata ttcccctttc aaatttttcg gtgtcatttt
      421 aattttttat ctttgtgcct tatagcaaag caattaccgt gccaatatta tttattctaa
      481 aaacaatttt tttatgttgg aattacatac ttttataaaa tttctttaaa gtttataaat
      541 tttgagtgtg aaaaataaga tttataaaag aaaaaattct catattggga aatttttatc
      601 aatacgagaa ttatcaattc gagaaatcgt ttatttgtct taattcttcc tttattatgc
      661 tcttattttt tatatgtcta ttgttttgtc agatatatta ctacttttat tttctataaa
      721 tatatggcta taaccttctt acgcataaac tctataaatt tatatacttt atatacttta
      781 tattctttat tacccaaagc ctccaaaatg gcttaaatct tttcatagct tcttacagaa
      841 gtttacatgg tcatcccccc aataagcaaa agtgcaatat gtgtaccatt gtgccctact
      901 tgcgactatt gagctgtcga aattcgcaac ttcgcattta tctgatgaaa tgcactatac
      961 aaaatattca taacatccac aacagagtta aagttaccta ttcatattca ctgtaaaaat
     1021 ttcttccaca ggaaatgtaa ttttaaccaa tcctattgag acaaactcac cacttatttt
     1081 tttgaactca cgcagtaata catcacttgc ccgaaaaaaa gcctcacttt catcatctcc
     1141 agtaagtgct attgtgcaat ggggtaccca acgattgggg tgtaccattc ccaaccattt
     1201 gaatcaaaat cttgtagtac ctcatataat tctctctgaa actgatacat actgctattc
     1261 attataggtg atacaaacac cgttttagta tcattaaaca tgcctactga accaatgtaa
     1321 gcaggtatta ccttatggtt ttgtgcaaac ccctttagct tgtctatgca acaagcctca
     1381 tccacatcat tgaaacaagc caaagtaaga tgaggtcttg ttttccattc taagtacttc
     1441 gtactaattt tttcatcagc gattttttta gataaatcaa aaagttgctt ttccgttttt
     1501 ttatcataat atagctctat cgcatattgc ataataacac ctccaccata aagtaaaaat
     1561 acctatctat aaaaacacac aaatacctat cattttaata ttatattact actgttcctc
     1621 ttccaatttt ctatatagtg tagccaaacc tatgcctaag tcttttgcta tcttcttctt
     1681 cgtctttgta tctcttccat acttattcaa caacttgttt atgtaagtca actctaattc
     1741 tttaattgaa agtatccttt cttgattctc tactatccct ccaactatat catcttcaaa
     1801 tattatattt acatccttat ttttataaat atttccatta atattataat agtttaaaat
     1861 atctaatgga agcatatctt tatatattat tccatcatct ccaaccaaat tcatcatata
     1921 ttcaactgca ttttccagtt cccttatatt tcccggccaa ttatagttaa tcaacatatt
     1981 cattacattt tcttctattt tatttaactg aatacctaat tctaaagaat atttagaagc
     2041 aaacttcatc attattgcct caatatcatc ctttctttcc ctaagaggtg gcaaatttat
     2101 aggaattaca ttcaatctat agtataaatc atccctaaac ttaccttcat ttactaattt
     2161 caataagttt ttatttgtag cagcaatcac tcttatatct aaatctataa gtttatttga
     2221 cccaattctc gcaaattttc tctcttgtaa aactctaagt aactttgctt gtaaaggcat
     2281 tgacaaatct cctatttcat caagaaatat aacaccttca tttgcaagtt caaatttacc
     2341 tactttacct ccactactag ctccactaaa tgcacctttt atatagccaa atagctcact
     2401 ttcaaggaga ttttctggaa tagcagcaca gtttatcgca ataaatggct tgttccatct
     2461 gctaccttca gcatgtatag ccctagcaat tagctcttta cccgtaccac tttctccagt
     2521 tataagtaca gttgaatttg attttgctaa tttcttagtt ctctctttta cttttaacat
     2581 tgcttctgaa tttccaatta tagactctat atcactattt ccccagccac tattcacttt
     2641 tccatgtcct ttatgattga tatatgtctt gtcaaatatt attattttgt cgtattgatt
     2701 tatatatgga tataccggaa ttattttggc atttatatta taaattttgt tatcaatatc
     2761 aatttctagt aattcatgtc catttgagga agattcaaca gatactatat ttactatatt
     2821 ttctattata tttttatcta tatctaattt ttttagagct atattgttta tataagatat
     2881 tttgctattt atgtctagta ttataacgcc tttttcaaca ttttcaatga tttctatcat
     2941 catatccatt tttctactgc tattttttga cgcttcatgt tcttctattt tcatagaaat
     3001 taaatcgcat atatgattga caaattttaa ataattatct atttttgcac ttatttctac
     3061 ttttttagtt ttatctgtac taatagcacc aattactcct atagttcgat tattatattt
     3121 tattggaact gctattatta ctttatttag gcatttcatg taatgggaac attctataca
     3181 aagctgatta tcacatatat ccaatacgac taattcctga cctgtctgta taacattgtc
     3241 ataaataaat ccttctgtaa caacgctttc atttatcttt gatttataca gacctgtacc
     3301 actaattctt attaatctat cgtcaactat ttcaatatct acatctaaca cactagctac
     3361 tgtttcagtg tattttatca tttcttgttg aaattctttt aatttactta acatagtttc
     3421 ccccattaga atttaattta ccaaattatc agtttagcta tattttaaca tatagtcact
     3481 ctttaaaata tatataaaac attacttatt tatatatttg cgttaaaaca gacaatatta
     3541 atttataaaa agtttgtttt atatagtaac cttaattata atatgcagac aataaaataa
     3601 atcacaatac aataataaaa aaaagctttc ctcatataac aaatatattt ttgacataaa
     3661 aatatacatt atatgagaaa agctcaatag ttaaatattt agatagattt ttatatagac
     3721 ttttttaata taaacttttt taattgtaga ctttttttat tagtttttaa tttttattag
     3781 ttttgttatt ggttttattg ttataatact tataatactg ccattgcttc aatttctaaa
     3841 actgcatctt ttggtaattg agcaacttgt acgcatgacc ttgctggtgg attttcttta
     3901 aaatatgtag catatacttc attaatatca ttaaaatcct ttaaatcttt tacgaatact
     3961 gtagtcttaa atattttatc catacttgta ccagcttgtt ctaatattgc ttttacatta
     4021 tctaaagaag cttttgttgc ttcttttggg tcagatacta actcgccagt cttcatatct
     4081 attggaagtt gacctgatgt agaaactatg tttccaactt gaattgcttg agaatatggt
     4141 ccaattgctc ctggagcttt ctctgtagct attactactt ttgacatgac ttcacctcct
     4201 attattaagt tatatttaca ggaaaataaa atttcctaaa caccaatatt aatacgaacc
     4261 tttagattaa atttcaaatc taaaacttca aataatcaat acttagatga ttatgtttat
     4321 ttgtgtcttg ttaactttta ttaaagcaat taacgtgcca aactttattt atatataaaa
     4381 ttttgtgaag tcattcaaaa tagttacttc tgaatttttt cgtaaaaaaa cgctctaaaa
     4441 ttactttttt atgatgtcaa tttttttctc atatctagaa atttaccaac atgagaattc
     4501 ttgttttgag aatttacaga ttaaagttat tttttaacct taaattctga acctcccatg
     4561 actaaagtca cagggttcct gcttcataga attttgcata atcaagttat tacatatgaa
     4621 agaactatag ttgacaatcc cactattata aataataaaa cctttaccca taccttattt
     4681 accctagtta tcatagagcc tattgaaaat ataacagcta aatataataa taaccaaaaa
     4741 attatcaata tctaccactg ttgctgaaaa tccaaaaaac taccttttga tagtcttact
     4801 taacaatcta attaatctca taataaattt acaacttata aataaattgt tatattggcc
     4861 gtatctcaac aactttctcc tttcctagtt ttaaatcttt tatagaattg taccacgtct
     4921 aagtaaattt tcatactatt aagtcttatt tctaataaat cattagctct cattctatgc
     4981 ccaataatgt aagattgcag taattttatt gattttcata gttttattta atatacttac
     5041 attaattatt ttcatatgaa attattattt atataggggg atttttttaa tatgagcaaa
     5101 agtgaattaa cagcagaaac aacagaagaa atgttagaag tactaagtgg taaagattat
     5161 gatattgcat gtcatttaca tgaacttggt aaatcattag attgtaaaat tgaaccaaaa
     5221 acaggtgctc gttcttacaa aatagtatat tcaactaaga aaccaaaacg tagcttattt
     5281 actattgaat gtaatgaaaa aaaatggaga gttaaagcaa atctttttca tctaaataca
     5341 tataaagatg ctgtggagga atgctctaaa actattaaag atagtataac taaaactcgt
     5401 acttgtaaga aatgtaattc aaagtgtatt ggaggttctt cgtttgaatt agatggaaag
     5461 tcttacctga cttgcatagg aagtggtcat tattttgcaa atatggaaga aatggattgg
     5521 aaaaacctag aaaaattaat tactaaagaa aataatatta tgcaggaatc tgtatagttt
     5581 tttaagggta attattaaaa tatatgagta acaacagata cttaaatagg cataaaaaaa
     5641 taaagggtat aataaggata tagaataaaa ataaatgata tagcacaaag aggctgtctc
     5701 aaaatacaga taagcctctt tttattgttg aaatgataag aatatattca attttataca
     5761 attttataca aacatactac gccaacttac ccatttcata tgcctgtttc attgccttac
     5821 ttcccttaat atcacctaca ttccaagcac ctacaccata tactatacct ttttccttag
     5881 aaccatttag acatgatgta aatcctctaa atccttctat tgttctttcc atatcagcca
     5941 cattttcatc tgctgctgta acgataaaat agaaatcttt atcacaaatt tcagtatatc
     6001 tagagcaagt tctatcaatc atagttttca tttgtgcatt catagtataa aaataaactg
     6061 gagtcgctaa aacaatcaca tctgccccaa tcattttttc aagaatttct cccatgtcat
     6121 ctgtctgtga acaatttgct tctttttcat aacaagcacc acatccagta caatagttaa
     6181 tatctttatc ttttaaaaat atcttctcca cttgattttt agattctaat accccttgta
     6241 taaactggtc acacaataaa tcagaatttc caccttttct aggactagct gatactatta
     6301 atacattttt actcataaga tactgcctcc attttcttat ttctactgct ctttaatact
     6361 ttttctttct caataatacc ttcttcatat ctatcaatct taaaatttaa tcgttccaaa
     6421 gttttttgca tttcttctat tctttttgct agttggtttc tctgctctat taaaagttct
     6481 tttctagctt tgatagtact gctcccttgt tgaaacatag ctacatactc aattaatgtc
     6541 tcaatagaaa gacctgcacc tctcatacac tttatgaaat taacccactc acaatcttct
     6601 tctgtaaaag acctaattcc acttttattt ctatttacag gtggtattaa accaattcgt
     6661 tcataatatc gtaaagtatc cgctgaaagc tcgtattttt tactaacttc tgaaatcgtc
     6721 atacatatct tctcctcttg atattgtata gattgaatta tttctcaaag gtttctgcta
     6781 cattctttaa agcatctata attttaatgt gttgaggaca gctttcttca cattgtttac
     6841 attcaataca atctgaggcc tttccataag ttttagtata attattatag tagaccatct
     6901 gtgttgaaaa tccagtatta agagcttgtt tttctgcatt gtacaacgca aaatagtttg
     6961 gaatagcgat attttttgga cagccttcta cacaatactg acaggcagta caaggaatta
     7021 aaattgattc gttgataatc tctactgctt catctataat attatattcc tcttgtacga
     7081 atggtttgaa attttgcata tatcctgtat tgtctaataa ttgttccata tttgacatcc
     7141 cacttaagac catcataaca ttatctttac ttgctgcaaa acgtattgcc caagatgaaa
     7201 ttgacatatc tggattgtag tcattcaata atttctctgc tttttctggt atctttgcaa
     7261 gtgtacctcc ttttactggc tccataacaa ttacaggctt attatgcttc tctgccacct
     7321 cgtagcattt tctagattgt atgctttcat tatcccaatc taaataatta atctgtaatt
     7381 gcacgaagtc tacttctgga tgctcactca agactttatc caataattct gcactatcat
     7441 gaaaagaaaa accaatattc tttatttttc cttctttttt cttttcttca ataaacttaa
     7501 agctatcaaa ttttttagct acttcgtaat gtgacacgcc tatattgtgt aaaagatagt
     7561 agtcaaaata gtctacacca catttttcta attgctcatt aaaaatggtt tcttgctctt
     7621 cttttttctt taaagccatt aatggaagtt ttgtagctat agtaaaactc tctcttttgt
     7681 gtctttttac tagagattct ctaagtgcta tctcactttt tcccatgtga tacacatagg
     7741 ccgtatcaaa atatgtaaat cccctttcta gaaaagtgtc taccatttta tttaaatgtt
     7801 ccatatcaat agttgtaaca tcattttcat cttttattgg taaacgcatt aatccaaatc
     7861 ctaatttttt tgcctccatt gctttacttc cccctttaaa acttgtttgt tttttctctc
     7921 tactttaact attcttacaa gtatataatt cttgtataat tatactttac tacttggagt
     7981 taacttcaag tcaatagatt tttttatttt taagacaaat attataaaaa tacagttctt
     8041 taatattaat ccattacatg tttctttcac cctccaattc tcaaacttca caaactccaa
     8101 catgtaaaga aatatatact ttaagaaatt cagtccatta atattactac aaatactttt
     8161 tagatatgtt taaaaagaaa tttcacctaa aagatttaga aaagatttag aaataggtct
     8221 tgtgtctatt ttaaaatata taaaacagtg gtaaagactt atttataaga taaaaaatga
     8281 atagtgtata ccctttttaa aaagtttttt cctttttata tttgtgatac aatgttaaat
     8341 ataaaaagga aaattttgta ttaaagaaat cttatttgtt gattttgtaa cttcaaactc
     8401 agcatcaatt tgattttaag attatatttt attaagtatg ctaaataaca aatttttaaa
     8461 gattgtgagg taaaaatatg aataagaaaa atttagctat attaatatca ggtatgatgt
     8521 ttttttctag ttcttcagca atttttgcag acaatactac aaagcaagaa agattaatag
     8581 gtaaaacaag atatgaaaca gcagtagaag taagtaaatt gggatgggtt caatcaaaaa
     8641 cagccattat agttaatggt aattctattc aaagtgcgct ttgtgcaaat ccatttgcta
     8701 agctaaagaa tgcacctata cttttagtaa acaacaacag tattgaaaat tcaactaagg
     8761 ctgagcttaa aaggcttggt gtagataatg tgtacattgt agatagtgga aatagcattt
     8821 cttctaaagt agaaaatgaa ataaaatcac ttaacataaa aataaataaa atagtaggaa
     8881 acaatatata tgaaatgtct acaaatgtac ttaaagaaat agataagata aaaaaggtag
     8941 aaaatgttgc agttgtaaat ggactaaagg gactatctga tgcagttagt atagcttctc
     9001 cagcagcaat acataatatg cctataatat tagtatcaga tgaaaacagc aatgatagta
     9061 gtataaattt cttaaacaat aggtctataa aaaaatctta catagttgga ggaaataaga
     9121 ttttatcaga caatacagta aagaaatatc caaacagaga aagaatcagt ggttcagata
     9181 gaaacaatac taatgcaaaa attattgata aattttataa agataaaaaa ataaataatg
     9241 tatttgtagc taaagatggt attaaccaag aaaatgcatt agtagattca ttatcaatag
     9301 gagtactagc tgctaaagaa aattctccta taatgatatc taatggtagc cttgtaaata
     9361 gtcaaaaaga atttattaaa aataaagata tagatgaaat aacacaagta ggaggaggat
     9421 ataatcaaaa agcatttgaa gatattttaa aactaaaaaa tgtgaacata agaaataaaa
     9481 ctaaaaaaat atctttaata caggctaaag aaatattaaa acaagctctt ccaggaagca
     9541 atattttagt ttgttattat gatgaagatg ataatgaata tgactgcaaa gttataaagg
     9601 ataatatcct atatgagata gaaattgatg cctactctgg taaaataata gaaattgaaa
     9661 aagatgatga cttaaatgat aataatttag gtacacaaaa tatatcattg gataaagcta
     9721 aatctatagc attagatgcc attcctaatg gtaatttaat ctattgtaaa tatgatgctg
     9781 aagataacga atatgaggct aaagtaataa aaaataagaa aacatatgaa ttagagataa
     9841 gtgcatttga tggaagaatt gtagatattg acatggacaa tgattctgat gatgactttg
     9901 atgataatga taagaataac tctaatacta atgacaacag ttctattatt agtgctgaaa
     9961 aagctaaatc aataatgcta gataaagtgc ctggtgggaa aatagtaaaa tttaagtatg
    10021 atgaagatga caaagaatat gaaggtgaaa taataaaagg aaaaactgaa tatgagataa
    10081 caattaatgc aattactggt aaaatattag aatttgaaat agatgattaa taaaaaatat
    10141 atattctatt aattattaca agcaataaag ccataaatat tgaaattttc aatatttatg
    10201 gctttatttt atttttttaa tttaaatcca cattatgcca ttatatatat ctatgcactc
    10261 ttgtaaaatg ggttatattt ctccagtata ttaaaaaaag tgagtgtctc aaaataaatc
    10321 ttctaactca taaagcactc tcctttgtat taaatcaaat atattttcat catttaaaca
    10381 attaagaaga gacttctctc tattttgaga caactccatt ttaatacact atttatacat
    10441 aaacatattt taaacaacta aaaagcaact aatatcttaa taaatatctc aatacatatc
    10501 ttcataacac atatcaccat aattacaagc agataaagaa ctctcctcat ttaaatacga
    10561 ctcaaattca tacccaaaca gaattgttgg ttctatatat atttccatat ctgtatatct
    10621 ccatcttctt acctttgcct ctataacctt gtaaaaatct tctaaactat acccttcttt
    10681 taatctttta tctataagtg ccttagttat actcaaatca gctttaaaat tttttcctga
    10741 ttcactattt aattttctta taataatttc atgtatgctt tctggatttt tgtaagtaga
    10801 atcttcagtc aaatcttcat ccgaattttc aaaggtattt ttatttaaat tctttttatt
    10861 taaattattt tttaataatt cttttttctt tgtctcattt tctgtttcat acccagtatg
    10921 aattatcaaa tcataatctt tgtctatact ctcttgattt atacggctgt atatgttggt
    10981 attactgttc ttaaacaact catttctatg tttatatttc attgtttttt ggttattgtt
    11041 aatagttgca tcaatgtatt tctctatatt tttgaaaata tcaccattct ttgttacaat
    11101 ttctgcatta ctactttcag aacaaacata actatataca gaacaacaat ttccctttac
    11161 tcccctactt attaatctca atatacctaa atctataaat tcatttacaa gtctacttat
    11221 tgtagatata gatacatcaa ggtcagatgc agctttcctt actgtcatca taaattgtcc
    11281 tcttggcaga gttcctttta atctttgtat attttctttt ctcattacat agtgattaaa
    11341 ccttattcta tttacatctc ttttttcatt aaaatataat actgctgaat ttaattgata
    11401 aaaactatta ctcatattcc cactcctcca atttaaatag ataatttgtt gtaaagtttt
    11461 tagatttttt aataacttat taaatgatta tttttattaa aaagtattct ttgatatttt
    11521 cattttaaag ttttaagtat aataagttaa tagtgtagat ttaacttttt tatttaaaca
    11581 ataaacttaa tattattttt aatataaaaa ttttattaaa tttagtatgt aattttttaa
    11641 tcttatttta ttccatctat actcttatgc taagtaataa ctttgataat atttccctaa
    11701 cttatgtttc aactggttta tattgcaatt tatttaatta cagcttattt gcataataat
    11761 tcgtccatat cataagttgt gtatttatat aaatacacaa ttaaaaataa atcactatgg
    11821 tatactaatt attacgaaga ctatacttat atgcaaagac aaatataagg catcttatat
    11881 cttttatcaa ttataaaaaa ttaaacgcta tcttatttat cataaattac aaaaacataa
    11941 aattttatta ctatattgct ataaattaat tgatacacat tttacacaat aaggagggct
    12001 atatatgaca aatgctaaaa gtaaaaaaga atatctaaat cgtatttgca aagtgcaaga
    12061 ctatatagaa gaacatttac atgaacctct ttctcttgat gaactttcta atatagcagg
    12121 tttttcaaaa tttcattttc atagaatctt caaagcaata gaaaaagaaa ctttggcaca
    12181 atatgtaaat aggctaaaac tagaaaatgc aactgctttt cttattcata gaactgacat
    12241 gactgttact gatattgcac actacttcgg ctttactgat tcagcagttt tctcgagagc
    12301 atttaaaaat tactataaaa taagccctat aaaatataga aacaattata gcaagaattg
    12361 caaagaacca tataaaattt ctcagtacaa tagaagcata tcaaaaccta aatgtaagaa
    12421 tactagagag gttaaaggtg aaattgaaat tctagaactt gataatatga atactattta
    12481 cactagatat actggttcat atggtaatct aaccagtact ttcccaaaac ttttagaacg
    12541 gttattcaca tatgcaagtg agcagaatct acttggactt gaaaacacac aaatattagc
    12601 catttatcat gataatccac aatttacaca ggagcatcaa ttaaggacta gtatttgcat
    12661 gaccattcca gataacattg ttgtcaaaga gaatgacaat cttggcaata tgataatacc
    12721 ttctggaaaa tatcttgtgg gacattttga tatttcaaaa tctgaatata gtgatgcgtg
    12781 ggattttatg tataatgaat ggctatcaaa tggtaattat aagctacgtg cctccttccc
    12841 ttttgaagta tatcttaaca acccacacaa tcaccctcaa aatagacact tggtcgatat
    12901 atatttacct atagaacctt tttaataacc tcacctaatc tattcttgta ttaaggatta
    12961 atatatccct attttacggt ttgataaaat tgataaaatg aggtgaacca atgaaagaaa
    13021 taaaaattaa tggagcaaag atacacaatc ttaaaaatat agatgtttct attccaaaag
    13081 ataagcttgt tgttgcaaca ggtgtcagtg gctcaggtaa gtctagcctt atgtttgaca
    13141 ttgtatttga ggaagggcgt aaacaatatc tgcaatcttt aggtatactt gcaggtattg
    13201 atagtgaaga taagtttgat aatattcaag gtttagctcc cactatagct gttcaacaaa
    13261 atattattcg ccagagcaat cctcgttcaa cagtaggcac aagaaccaat attctcaaca
    13321 tgcttacact attgtattca gtggaaggtc aaataatgtg tactatgtgt gatactcctg
    13381 taagcgataa tctaatttgc aataattgtg gatatgagga agaacgatta agaccaagtt
    13441 atttctcata caactcttca gatggaatgt gtatgaagtg ctctggacat ggtgcatatt
    13501 ttgagattaa tattgaaaaa ttagtccttg ataagcatga taccctaaaa caagtcttag
    13561 atagagcaaa gattacacct ggatatttga gagtattttc taaaaaattc aatgattatt
    13621 tagacataca attcttacaa ctacctgaag aaataagaaa tgaagtactc tatggtcatt
    13681 atgaaaatgg taaaaaaagt tcctctttat caaaggtatt tcacaatcgt tacaaaaggg
    13741 gcgaagattt aaatggagtt tatactatga ctgcctgttc agattgcaat ggttttaaaa
    13801 ttggtgaaga agcacgtaga gtacttttaa acggaaaaca tattggagaa cttggaaaaa
    13861 tgacgatttt agaaattgat gatttcctta aactcttaat aaatcaaggt aatttaaaca
    13921 catttggtac aaatcttgta aatgatattt tatccaaaac tcaacattta atagaatcac
    13981 gattaggtca tctatcctta taccgagaaa tgtcaacttt gagtggtggg gaaatgcaaa
    14041 gactattttt aaattcacat ctcgattcag agatggactc attaatttat gtgcttgatg
    14101 aaccaacagc tggattgcat gaatcagaaa aaatagacat cttaaaatca ctaaagaaac
    14161 ttaaagattt aggcaatacg gtcatagtag ttgagcatga taaaaacaca attgaaatgg
    14221 cagaacatat tattgatatt ggtccaaaag ctggtgttga aggtggtcaa ttagtatatc
    14281 aaggagattt agaaggtcta cttcaatccg acaaatcact tactggacag tatctatctg
    14341 gaaaatatcc aatgcctaat agaacaagca ataaaaacat tacacatact gataaaatac
    14401 cttgtataac tattcaaaat gcaaatacaa ataatcttaa aaatgtaact gtatcattac
    14461 ctttgggtgc tatggttgga atatctggaa aatcaggtag tggcaagagt tcacttatat
    14521 cagacaccct acttcctctt cttagaagcc aatttaataa ccatactatc aataatcaaa
    14581 taaattcttc agagagtgaa ataggtgagg aagacgatta tgcagttgtt gaaactattg
    14641 cagatagact gattggtact aaacatattt ctggatattc agagatatct caatctccta
    14701 taggcaaaaa tatgaactca actcctgctt cttatattgg tatatgggat aagatacgta
    14761 cactatttgc aggtcagcca gaatcgttag aacaaggatt tacagctggt catttctcat
    14821 ttaactccaa aggggcttgt cctaaatgta gtggtagtgg atatgaaaag gtctggttgg
    14881 gaaataatct aagtatagac catatatgca gtgaatgtca gggaaaaaga tttaatgatg
    14941 aatctttatc tattaaatat aaaaataaaa atatacatga tattttaaat atgagtgttt
    15001 ctgaatctgt acatttcttc aaagatattc caaatattgt ttcacactta aatgtattag
    15061 aacaaatagg tatggggtat ataaaattag gccaacctac accgacttta agtggtggtg
    15121 aatcccaaag aatcaaactt gcaaaagaaa ttggtaaaaa acgaaatggt aatatccttt
    15181 atgtattgga tgagccaact actggtctaa gtctatatga tacttctaag ttgattcaat
    15241 tattagatga attggttgaa aatggaaatt ctgtaattgt tgttgaacat gatatagatg
    15301 tattaaatgt ttgtgactgg attgttgagc ttggtccaga aggtggtgac aaaggaggtt
    15361 atataattgc agaaggttct ccaaaaactc taaaagaaaa tccaaaatct ataacaggga
    15421 ggtatcttta atgaataaaa acaattgctt agacttaatt tttgaaaaag tagacccttc
    15481 aagtgttggt atgagttcag aaaagctttc acaacttgaa cctttaataa tctcacaata
    15541 tagcaatata aatggtataa ttattgcaag aaaaggaaaa attgtctttg aaaagtacta
    15601 taatggatat aatgctgatg atacttttca tgttgcatca gttacaaaaa gtattatatc
    15661 agccttaata ggtattgcaa tagataaagg atatataaaa gatgttgacc aaaaggttgt
    15721 tgattttttt cctgaatata cttgtagtcc ttctgaaata tgtaaaaaag cagtaactat
    15781 acgtcaccta cttacaatga ctgcaccata cccttttaaa aatatgactg agtctttaga
    15841 aagactttgc aaacaaaaag attggataaa atataccttg aatcaacttg gtcaaaaagg
    15901 cgaaattggt actttcaaat attcttcagc tggaacgcac ctactttcag ctattataac
    15961 aaaaactact ggaaaatctg ctcgtgaatt tgctaatgag tacttattta aacctattgg
    16021 tatgaaagtt ataccagatt atgatatgaa agattttggt tttgaagatt tctttggaaa
    16081 aaatcttaag ggttgggcaa aagatagaca gggttattct ataggtggct ggggacttac
    16141 attgagtgct agagatatgt tgcgatttgg ttttctgtat ttaaatgatg gtatttggaa
    16201 taataaacgt attatatcta aatcgtggat tgaagaatca gttaaaatga atagtaatga
    16261 atacggttat ctgtggtggc tatgtaaaaa agatggtgtt ttgtggtatt cagcaatggg
    16321 aactggagga aatgctattt gttgtattcc acaatatgac ttagtaatag ccataccatc
    16381 taaaatagtg tttaaacctc gtgatagatg ggagttcatt gaaaaatata tacttacttc
    16441 tataatagat taattactct ttcataaact aattactctt tcataaacta attactcttt
    16501 cataaactaa ttactcttag atagccaaac cctccattat aacaccagac ttttgtttgg
    16561 tgttattatg actaatacta tatatctaaa aggagttgaa tactaatgga cacttacacg
    16621 acatcagagg tagcagattt aattggtgta catcctaata cagtacgttt atatgaagaa
    16681 ctaaacttaa tacctaaacc taagcgtaat accaatggtt atcgtatctt taatgatttt
    16741 catatagaac aatttagatt tgctcgtaca gccttgaaaa ttgaagtggt acaaagggga
    16801 ttaagaaaag atgcccttga gattgtaaga acatcagcga atagggactt tgataaggct
    16861 attagtcttg taaatcaata cttgcaacaa ttagaaatag aaaaatctaa tgccgaggaa
    16921 gcacttacta ttgttgcaca gattttaaat ggaaatactc cagaaacaaa taaactcttt
    16981 ttaactagaa aagaaactgc agaacactta aacgttacaa tagatacttt aagaaattgg
    17041 gaaatgaatg gtttgttaaa agtaaaaaga aaacaaaatg gttatcgtgt atatactgat
    17101 gaagatataa aacgacttaa aattataagc gcacttcgtt gtgcaaacta ttctctttca
    17161 gctattttac gaatgttaaa tgctttatct tctagtccta atactaatat taaaactgtc
    17221 cttgacactc caaaagatga tgacgaaatt atctcagtgt gtgacaaact gataacttca
    17281 ttgaaagaag ctgaacataa tgcaaaaacc atgaaatctc atcttcaaat tatgaaaaaa
    17341 caattttcct agccctccac tctaactcca gactttgatt tgtgtgttat ccttaagagc
    17401 aagaaaaatt caacacacaa atcaaaggag gaataggatg gaaaacaaaa atactaattc
    17461 tacatggaag aaaaaagtca ttcttttttt agcaagtcaa tatatttcct tatttggctc
    17521 atcacttgta caaatggcaa tgatatggta tgtcacactt cagacatcat caggtgtatg
    17581 ggtaacagtt ttaactgtat gctcctttat acctcaaatg ataatttctt tttttgctgg
    17641 tgtatgggca gactactaca atcgaaaggt actcataatt gtatcagatt caacaattgc
    17701 tatatctaca ttagttctaa ttctatttat gatgtcatca aatggcacaa caagtgaatt
    17761 aatagccata tcagtaatat ctgttatacg ttcactagga agtggtgtac aaacacctgc
    17821 tgtaaacgca atgattcctc aacttgtacc agaagaacat ttaatgcgtt ttaatggtat
    17881 aaatagtagt ctacagtcta tagtacaatt tatagttcct attgtagctg ctgcaatact
    17941 tggatttggt aataaaataa atcaagttct tttaattgat gtatttactg caattattgc
    18001 tattgtatta ttaatattca tcaaaattcc taaacatgat ataccaaaac aaactgaaaa
    18061 agtctcattt tttgcagata tggtatcagg gataaagtac tgtttttcag ataagttcat
    18121 tagaaaagtg ctttttactt atggagcatt catgcttctt tgtgttccat caggatttct
    18181 tataggactt cttattgaac gaacatttgg caagggttat atatacctgt ctattattga
    18241 aatgattgga tttttaggta tggttttagg tggattgatt ataggagttt ttggtggttt
    18301 taaaaataga aataagacct tttttctagc aatattatcc tatgctattt tttcaattat
    18361 tctaggtctt gtaacacaag cttggcaatt ttttatattt atgtttttta cgaatttttc
    18421 aattccaatc attcaagcat cagctatgac tatgttgcaa gagcatgtag caccacaaat
    18481 gctaggtaga gttcttagct tacctattat tatatatact ggttttattc ctcttggtat
    18541 gatgattttc ggaccaatgg cagatgtaat ttctattaat aatttaataa tcatagcagg
    18601 gattatactt ttattttttg ctttggctat cccctattca aaacaatttt acaagcaagg
    18661 aatatctaag tcaaatgaat ccgagtaata tatttaaata gtttaactcg atttatctgg
    18721 ttaaaaatga aggggcttaa aatggacttt ttaatttatg aagaaaattt tttatatgaa
    18781 atcaaatata ttttatcatt tcaacattga aaaataggtt tatctttatt ttgagtccct
    18841 ctctttatag caaataatat tttgatacta tctttattaa ctttatataa taataccttt
    18901 acttgtaggt tataatgatg aaatttatca aatcatataa taatacctcc atttatatca
    18961 taaattaaat ttatagtaca aatggaggaa aataaagtat ttatatagtt taagtaccta
    19021 ttaagttttc cactaagtag ctctaattgt actgaacttc ttactaaatt atattgaata
    19081 attataaaat aaaactaact attacactac ataaattaaa gtatacaaat tgcactacat
    19141 aaattacact atacaaagta tattaaatca cctattaaat tgtcccaatt ataattatac
    19201 tgagttatct actaaaagat aactttcttt ttttatctaa aataatatat atcataaacc
    19261 atactacaca atgtacagcc aaaattacaa tatctttgat aataatgaca ttaccattaa
    19321 taatctccat aataccatta aatgtagcaa ctgaaggcat tatatagcat aaattcccta
    19381 taccactggt attaacccct agaagatata ttaacaaagg agtacctata aataaaatca
    19441 ttactatttt aatataaaca attcctacca taagaccttc tgacaacttt ccaataaata
    19501 aacctataag tgatgaaata aatgctgaaa atacaacgag taacaacatc attatcatat
    19561 ctaatattga aatatccaaa catataaata cagttatcat tgaagataaa cacccacata
    19621 aaagacccaa aaatactttt tgtataatat actgacttct actctgtggc aaaacttcat
    19681 ttataaatga tattccatct tctttttccg atataatatt cattgcatta aaggtgcatc
    19741 ccataaacat agcagtaatt aaaatcatag caataaaaac attttgaaac tcttttaaaa
    19801 tactatcttt aggcaatatt gtaacctcaa catcttttaa atcacccttt agtctaaaca
    19861 tctctggcaa tgtctttcca acatttttta tagcattaat ctcatttcca taaaacacag
    19921 tttttattcc tttaccatct ctaacaactc caattgtgtc cgttttaata tccttaattt
    19981 cacgtattaa atgcattttt gtgtcatata cacttaccat accatacttc ttcaaccact
    20041 gctctgtttg tacaggaagt gtatccttca ctataccaaa acgtatctct cctaatgaag
    20101 atatatcaat tgttcccata aaatttatta aaatcgccat aacaactggt aaaaagaagg
    20161 aaattataca cattttatct ttttttatac tctttaactg gtaacgtaat cctatcaaga
    20221 ttatccctcc ctaaccaatt ctttattaaa aatatatttt acaagtaaaa atagaactat
    20281 tattgtcaaa gaacacacta caaaataaac taattctttt gaaaaattca tgaaaaacgc
    20341 atttttaagc tgactataaa catgatagaa gggatgatat ttaatccaat ctatttcaaa
    20401 agatgtattt gcagatagaa atataggtgt agttatgaat acagcaacca caagatatat
    20461 aagagaaaat tgcttaaaat ctctcaataa cattgagcat cctattccaa tcaaagacat
    20521 aataattgat aaaatactag cttgaactaa tacttgtgga agtattttta ttccttctaa
    20581 aaatccaata ttaaatacta ctaaaagaac tgtaaaacat aggtcacata taaaaaaagc
    20641 aaatatcttt gataatataa aaagacttct ttttacaggt aaaataccag taatacgcat
    20701 tactcccatc tgcttttctt taaataataa agaggcaatc cctaaaaatc caatagctac
    20761 aatttcaaag aataaaatct cacaagtcat gtcttttctt tgttttatct cagatgtatc
    20821 cttatcatta atttgaatta ttgcattgtt gtctgatatt ttgctattat ggtctttttc
    20881 tgatgataat aatgacaatg catagtcagc tctataattg tcaactcctt taatactttc
    20941 atgtaaaatt actttcggct tactggaact catatcaata caaactgcac ttgtatcttc
    21001 atcaagtttt gcttttaatt cacctataga agaaacttga ttaattaatg gagatgcact
    21061 catgcttata ttctctggat tatatagata tacattattg tgataactat cttcatccat
    21121 aaactttaca taaccaaaat taatataaca cgaataaagt atgagagagc caagtgtcag
    21181 cacaaaaaat ttaccataaa tcatcatcca aaaatctttt tttactaagg taaaaaattt
    21241 agaatacatt acactaacat ccttcctgtg tatttaataa aaacttcttc tagtgtaggt
    21301 tcttttgaat gtacacttaa gatttcatca tatttaaaag ttattccaga ttctaactct
    21361 tgtatatcta caatttcaat atctcgattt ccattatata caaattccac ttcaacttta
    21421 ttattgctat ttttcatttt taaatttttg ggtttatcta ttaccataat ctttccatct
    21481 gcaataaaag ccacattgtt acacattaaa tctgcatcta gcatattatg agtagtcaaa
    21541 aagatagttg ttcctttttt tcgttcttct tcaataatct tacgaaatag tacagctcca
    21601 gatgggtcaa gtccactagt aggctcatct aaaaataaca actttggatt acttaccaat
    21661 gctcttgcca tgctaatacg ttgcttcata ccttttgagt aggatgatac aggcttattt
    21721 ataaactctt tcttaaactc taacaaatct aagagttcat atatgtctct cctttgattt
    21781 ttaggataaa aagacgaaaa atattctaaa ttatcaattg cacttaaatt ggtatataaa
    21841 taaggaaatt caaataaaac accaatcttt tgatataaag attctgtgta tgctttaact
    21901 tccttaccaa aaatggatac gtgaccattg taacctttta aaacaccatt taagattttc
    21961 tgtgttgtgg attttcctga accattaggt ccaaggaatc caaagatttc tccttctttt
    22021 acttcaaaat taagtccatg caatatctgt ttatcttttc cataagaaaa ttttaactct
    22081 cttactttta tcatctatca taacctcctt tatcattttt ttgtcgtcta tcccaccatt
    22141 ttataaattt aattttaagc ggaatagaaa gcaatattat caatataata gtcaaccatg
    22201 tataccattt cataagtact cccccttgta accttattta attacgcttc tattttttaa
    22261 tttatttaac ctattttatt tctatttggt gaaatcagag tgtctctctt gtgaaatcga
    22321 agtgaaataa taaaaagctt aataaaaaat cttgttttca tcaggaaaac aagacttttt
    22381 attaagcttt tcattaagct ttttattaga ctttttcatt aagctttttc attaagtttt
    22441 tttattttat tctctttaaa tacttacgta tacaaataaa aatattttac atcagatact
    22501 tataatttat aaattaatac taaattattc atcaattgga atcataaaat aaaactctac
    22561 tcctctatca cgattattca ctccatattc taacccttgc attgtaagta tttgtgaaac
    22621 aattgcaagc cctagacctg aacctcctgt acgctgagat tgaacactac gataaaactt
    22681 agaccaaatc tttgaaatct catcttgctc tataaaccta ccatcattat aaatttcaaa
    22741 taaaagcaag ccattttcac atgtaatcga taaatctaaa ttaccattat atacaacatg
    22801 cttctttgca ttaataacta gattctctac tacttgttcc attctcattt tatctgccac
    22861 tacaaaaact tcatactctg gcaaatcata tgtaaaataa aaattggcat ctggtatatc
    22921 aattaaaaga cgacctgcca cagtttcaac aaactctata aaatcaaaac gctctgggtt
    22981 aagtttagaa actcctgctt ccaatgcaga taagtctaat aatgatacaa tcatattgtt
    23041 cattctatca gtttcttcta ttataacatt catataattt ttcttttttt cttcatcaac
    23101 ttcatctata agcccctctg tatacgcacg tataatgcca agtggagtct tcatttcatg
    23161 tgaaattgta tctaccaact cctttctttg ttccaatagc attctttcct tatttacatc
    23221 cttttcaagt tgaatatttg cactttctag gtctgataat gcctgttgta gatttgtaga
    23281 cattgtattc aggctcctag aaagttctcc aaattcatca ttagtattta cagtacatgg
    23341 attagaaaaa tcaagttggg acatactttt tgcagattta tttatagatg tgattggttc
    23401 tgaaataaat tttcccaata agaaatcaat actcataata aatataacca gtattataaa
    23461 ccaaatccaa aattcaaatt tagagtttat cgaaaattct tcaacaacca gataaaataa
    23521 tataattaac gctcctgata atttagaaag taaaaacact ttttttctaa ctgaatatag
    23581 tccaaaattt tgtttaatcc aatttgaaat atctacattt ttcagttttt ctataatctt
    23641 tcttaaacta ttcattcctt aacctcaaac ttatatcctg aacgaattaa tgtaactata
    23701 tggtgtcctt cactaccaag ctttttgcgt aaggttttta tatgtgtatc tacagttcgt
    23761 gtgtttcctt caaaatcata tccccatata caatttaaaa gtttctctct ggaaaaaact
    23821 tgattagggt tttccataaa taaacgcaat aattcaaatt ctttatatgt taaatcaatc
    23881 aatttatctt ctacatacac ttgtcttgat gctaccataa taaaaatctt tcctaaactc
    23941 aatgaatttt tgggaatatc agtagtgtat ctacgtaaca aagcattaac ttttgctaaa
    24001 agtacttttg ggctaaatgg ttttgttata taatcatctg cgccatattc ataacccttt
    24061 aatttatcct cctcttcacc tttagctgtc aatataataa taggtatatt agtcatttca
    24121 cgtgaaactc tacacactga aaatccatct aaatacggca tcataatatc caatatcatt
    24181 aaatctatat tgttgctctt taatattgta agtgcctcga ctccatcatc agcagttata
    24241 caagtatatc ctcccttttg catatattct acaataatat tttgcattct tttttcatct
    24301 tctacaacta gtattttagc catttctatt tatcacctct tttttgtagg ctttatttta
    24361 gtttatatta atttatttat ttttcaacta tttttttata gtatttttta tagcattttg
    24421 atagtatttt ttagactatt cttaatggaa ttgatatcat agataaaaat agcctactaa
    24481 ctttttctat gttagcaggc taaaatattt ctaataataa ttatattatt ttgtcactat
    24541 tctatttttt cgattaaaat atattctaaa gcaaatatct tcaattaatg aataaattgc
    24601 acttgttata aagtacagac ctatggctac tggagttcta acagttagta taagacttgt
    24661 tatggtagtc accacagcca tttgtttgtt aaactttact tgagaattta tttttaaata
    24721 tggtatataa ttcactaaat ttgaagctaa cataattaat gtatatatac aaggtaatat
    24781 aaacaaatta tcaaatgtac ctaaattagc aatccatgga attataattg ttgtaaattc
    24841 ctttgtcata tctaaacata catgatataa agcatatact actggcattt gaaccaaaac
    24901 tataagacat cccagcatac tcttcatact ttctacagaa cttacttgta tttgcttttc
    24961 caattcttta gtatcattct tatacttttc ttttatatat tccatttttt cagctaattc
    25021 ttgctgtttt tttacagaaa atctttgttt taatgatagt ggcataagta ctaatttaac
    25081 tattaaagtt ataagtacaa tagaaattcc aaaatcacct gtaaaattaa ataatatact
    25141 taataatcct tgcaatatac ttgaaatgaa atccatttta ttctctcctt tttattttta
    25201 aactttagaa tttataatag attcatttca aattaaaaca aactacaata cctccaaata
    25261 tcatatttct gaaaaactat atactgttta ggcagtcgtt cttcagaata tgtaattcta
    25321 tttacaaata tgtctcttat taaaacatac ttaattttat gatttaagag gtctttacaa
    25381 aaataaaata tacttccaat gatagatacc aataatgtca tataaattag tacatataac
    25441 atactatcca tatctaatct catcacatca cctcttcatc acttgtattt atttttagac
    25501 aatttcaagt cctaaataat tccaacattt atatttagtt ttaaataatt atagtataga
    25561 aaactcctaa tgtaaatata tatattatta tatttatcat ttttattcgt catatttaca
    25621 tttataaagt atataatttt atcactctta atttttaata aaaatcacct aaagtattct
    25681 ttttttatct ctgaacaaaa caatattaag tttttatagc ttattttcaa attatagtcc
    25741 ttaatttaat ataaggctca atataata
//
LOCUS       DAEQCW010000051        25482 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.051, whole genome shotgun sequence.
ACCESSION   DAEQCW010000051 DAEQCW010000000
VERSION     DAEQCW010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25482)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25482)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25482
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.051"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            143..1108
                     /locus_tag="KRO40_002088"
     CDS             143..1108
                     /locus_tag="KRO40_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBH2092906.1"
                     /translation="MSKLKKFVILLAFLVVIFPISVYGYFYYKLSAIHDSSISSDLLD
                     NNDHKNEDGIINILLMGTDARPNEDSSRSDAMMILTIDNKHNDIKLTSLARDSYVDIP
                     GHGKQKLTHAYAYGQADLLIQTIEENFNIDIQNYACVNFESFMYIIDAIGGVEVTVEK
                     GEIRELNKFIPETYKWNKSDDKGSIQYIRNSGKQTLNGYQALSFARIRHNDTAFARDG
                     RQRQIIQAIIKKTETLPVTKYPGLLDAVLPYVKTNMKPNAILSLGAQVLKMGDLNIKQ
                     FEFPIDDEIHSTGGIYGKAGWVLRFDPDTLDILHDFIFNDIEFKQ"
     gene            complement(1306..3417)
                     /locus_tag="KRO40_002089"
     CDS             complement(1306..3417)
                     /locus_tag="KRO40_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding glycosyl-hydrolase Cwp19"
                     /protein_id="HBH2092907.1"
                     /translation="MKKISILVLSLIMTLTMCSVSSFADSSNDKEMRAAWISTVYNLD
                     WPKTKNNEAKQKKEYTDLLDKLKSVGINTAVVQVRPKSDALYKSNINPWSEYLTGTQG
                     KDPGYDPLPFLIEEAHKRGMEFHAWFNPYRITMADESIDKLPANHPAKKNPSWVVKHG
                     NKYYYDPGLPEVRKYIVDSIAEVVQNYDIDGVHFDDYFYPGVSFNDTATYQKYGKGQN
                     KDDWRRENVNTLLRDVKASIKSIKPNVVFGVSPAGIWRNKSSDPTGSDTSGNESYVGT
                     YADTRAWIKQGLIDYVVPQLYWPIGLKAADYSKLVAWWANEVKGTNVDLYIGQGIYKQ
                     GQSSYGGQNIAKEIVQQVTLNRKYSEIKGSMYFSAKDIANSTSIQKDLKSLYSSSEEP
                     VTPPSNVKVEKLRGDERYDTAVAISKKGWATNSDTVVLVNGYSIVDGITSTPLATSND
                     APILLVNKDNIPTSTKNELKRLNPSKVILIGGNNSIGDKVESEIKDTLSNVSINRVGG
                     SDRYSTSLMIAKELVKTNPVEKLYITSGTGEADSLSIASKAGEEKQPIVLVSKDNVSD
                     EVYNWISDLKVKDAYFIGGNLSISDSVINKLDKVITNDVSKNRIAGENREETNGKVIQ
                     KFYPNAEYSSMFVSKSNQLVDALTSGPLAAKLKSPVVMLGNSVTSAQKTALEPKKTTL
                     VYEAGDGINQNTLNTFLNLVK"
     gene            complement(3719..4426)
                     /locus_tag="KRO40_002090"
     CDS             complement(3719..4426)
                     /locus_tag="KRO40_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBH2092908.1"
                     /translation="MMNIKNKKHILKKFIAMVLIAGVVTVEAGAITASAAEPTNSPMS
                     ATVDQCDFLNVRSGASANDAVVGKINTGDKVEVLELHSNGWIKIKSVDNVTGWVNGDY
                     LTIQGGNVDAKVQNVLNLAFKQQGKPYKWGATGPNSFDCSGFTSYVYKNGAGVNLPRV
                     SRSQATVGKKVSRAELKPGDLVFFGSGGSINHVGLYVGDSKFIHSPQTGDVVKVTSMA
                     PGTNYAKRLITATRVLQ"
     gene            complement(4625..6538)
                     /locus_tag="KRO40_002091"
     CDS             complement(4625..6538)
                     /locus_tag="KRO40_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBH2092909.1"
                     /translation="MRESIDLEKESFFNRLFKKYKFRHLTLLILDICSVLVAFRMSLS
                     LTGNLNAFTTNDIIISVCIYIVLHIVSFRLFKCYNTLWRYAGEEEIISIFVATLAYLI
                     PIYIINKLLGFDYPIMFYVLNTIFIIMFTSGARIAYRAIRIVMNKTYSRGKVSNILII
                     GAGDAGEMVIQELKRNPELKKVAVAIIDDDKNKIGRIIHNVKIVGTTSDIKDVVEKYN
                     VDEIIFSIANIEKRRKKDIIDICKNTNCKIKTIPGIYEIIDGKVDIKQIREVEIEDLL
                     GREPIKTNLREISNYIEGKVILITGGGGSIGSELCRQIAGFNPKELIIVDNYENNAYS
                     IQQELLRKYKNKLDLKTVIASIREEKRMDEIFNKYKPEVVFHAAAHKHVPLMESSPGE
                     AIKNNIFGTLNIAGLSSKYRAKKFVLISTDKAVNPTNIMGATKRAAEMIIQTMNAESQ
                     TEFVAVRFGNVLGSNGSVIPLFKKQIEDGGPVTVTHPDIIRYFMTIPEAVGLVIQAGA
                     MAKGGEIFVLDMGEPVRILDLAKNLIKFSGFEPDVDIKIEFSGLRPGEKLYEELLMSE
                     EGLLDTEHKKIFIGRPIDVDREKITKYLKLLREITNNEEVEKIDGIMRELVPTYIKPE
                     DANIKEIATTREK"
     gene            complement(6622..7713)
                     /locus_tag="KRO40_002092"
     CDS             complement(6622..7713)
                     /locus_tag="KRO40_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH2092910.1"
                     /translation="MKTVCYLADGSNPHTLKWCSFFKNKGYDIHVISLNGGHMEGIKI
                     YNFGSNVEELKNENISKKTGYLGSIKQIKKLVNEIKPDILHAQYASSYGFIGSLLGYH
                     PYIISVWGTDIYDFPNNGFIQKQIIKHNFRKADYIFSNSRDMAKEANKYTAKHVDVTF
                     FGVDMDRFKPMEVEKEDAFVIGIIKSLEKKYGIEYLIQAFKMLKDEYKDKKIILKIGG
                     SGSQMDNLINLAKELGIENDVQFLGRISPENVSKTFNSFDVTVFPSLREGFGVAAIES
                     EACEVPVIVTNVGGHPESVWENETGLIVEPKQPEEIKNAIIKLMENDELRLNMGKKGR
                     QFVRENYEVNLNFNDIEKIYDSIFDKYKK"
     gene            complement(7719..9086)
                     /locus_tag="KRO40_002093"
     CDS             complement(7719..9086)
                     /locus_tag="KRO40_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="HBH2092911.1"
                     /translation="MYFVSMFLMPLKKEYKFYILGGKKMKIAIAGTGYVGLVTGVCLA
                     EVGNENVVCVDVDEQKVKSMKLGIAPIYEEGLEELMVKNYNRGRIDYTTDYKKAYEDV
                     DVILIAVGTPERSDGSANLDYIKAVAKQIAETVTKDTLVVIKSTVPIGTNEEIEDYIN
                     RNLKNDVKVELASNPEFLSQGTAVKDTLHASRIVIGVESEWAREILEEIYKPFNQPII
                     VTNRNSAEMIKYASNNFLALKISFMNDIANLCEIAGANIEDVALGMSYDDRIGSKFLK
                     AGIGYGGSCFPKDTKALHWLSEHNGYELKTVKAAIEVNESQKLKLVRKASKLVESFQD
                     MKVAVLGLTFKPDTDDIREAPSIPNIKYLLERGARVTVYDPIGVNNTKKIFGDSILYA
                     DSVDDAIEDAEICFIMTEWKDVLNYDIHKYKEKMKNPLVLDGRNCYKIKDMEELGIEY
                     YSIGR"
     gene            complement(9040..9792)
                     /locus_tag="KRO40_002094"
     CDS             complement(9040..9792)
                     /locus_tag="KRO40_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092912.1"
                     /translation="MNEPLVSIITPVYNSEEFLSETIKSIQNQTYKNWQLLLVDDCSK
                     DNSSEIIKSFRKEDARIKYIKLEKNSGAAVSRNVGIKNAEGRFIAFVDSDDLWDSRKL
                     EIQIEYMLKENVGFSFTSYRYMRQDGSKTNKVARAPKKIDYEGLLRNTIIGCSTVVID
                     KEIVGEFSMPLVRRGQDTATWLQLLKKEKYAYGIQEDLVNYRLVGNSISSNKIKALKR
                     TWNTYRNVENLSLPKSLYVFCFYVFNAIKKRV"
     gene            complement(9840..10748)
                     /locus_tag="KRO40_002095"
     CDS             complement(9840..10748)
                     /locus_tag="KRO40_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092913.1"
                     /translation="MYKYKFTVFTPTYNRAHLLENLYNDLKAQTYDFNDFEWLIVDDG
                     SSDSTKELVEKFISENKLNIRYIYKENGGKHTAINLGVKNADGELFFIVDSDDGLIKD
                     SLEIANDEWDSLENKEGFSGVVGLCVYPSGDLIGTEMPEDKKICHFADLYFKYGVKGD
                     KSIVFVTDELIKFPFPERKEVRFLPESVVWNEMSKYYKVICVNKPMIIRDYLDDGLTK
                     NILSKNALRGRALEFLYLINQNTYPLSRYPYMWIKNYINLARYSLLSDSHYFGELRKV
                     SDKLLYLALFPLGYYKYIGQRKLVSK"
     gene            complement(10770..11519)
                     /locus_tag="KRO40_002096"
     CDS             complement(10770..11519)
                     /locus_tag="KRO40_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092914.1"
                     /translation="MKKNLVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCST
                     DNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQFIAFLDSDDQWNSSKL
                     EKQVNFMLENDYVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNILGCLTVVID
                     KSKLDFEIRMSGVRHEDYVLWLSILKKGHIAHGINEVLALYRKSSNSLSGNKIKAAMW
                     TWNIYRNIEKIPLYKAIYYFINYGINGIKKS"
     gene            complement(11548..12723)
                     /locus_tag="KRO40_002097"
     CDS             complement(11548..12723)
                     /locus_tag="KRO40_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol glycerophosphotransferase family
                     protein"
                     /protein_id="HBH2092915.1"
                     /translation="MDKVKFLINMLLAFFIYPFNKHKFNGRDIWLIGGHSGDIYNDNS
                     KFFYEYMLKEHNDVETYWVVNKDSKVFDKIPGKKLIRGSVENYLYYYNSKAIVFSHAP
                     SADIAPYNFAVPVLNYFHKKTIKVFLNHGTISFKKRKPMNKKFKNIIDNLYKSYNIVT
                     ASSEFERNVMVNDWGMLDDSVYIIGNARYDNLPTNEVAQTRDILYTPTWRDWIKFSSG
                     KFTDTDYFKNIMNFLNDDKLNKILDEKDINVKIYMHHLMHEFIDDIKENITGKRIVFL
                     DKGVTLANEIRKSAANITDYSSVAIDFLYMNRPILFYQFDLDEYMEKVDSYIDLKSEM
                     FGSLAYNNDEAVNKLIDIIENNFEVMDNQKNERNKFFRYNDNKNCKRIYDCVLSKIK"
     gene            complement(12738..13577)
                     /locus_tag="KRO40_002098"
     CDS             complement(12738..13577)
                     /locus_tag="KRO40_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBH2092916.1"
                     /translation="MLISLIMPTLNRYDDIYLLMDSLENQTYKNFELIVVDQNDNSKV
                     KEIVDKYIDKLDIKYIKSSKKGLSYNRNVGIDNAVGQIIGFPDDDCVYENDTLEKVIN
                     FFNKNKDYKIYSCKTMDSNKVDAFKKMYDGTCDITSSNVLDTITSITFFIDFEGKDYT
                     RFDEKLGVGGEFGAGEEIDYVLNLLSLGFKGKYFGNDIIYHPAKKHSKSKEKYQKDYN
                     YGRGFGALCKKEIVYRKNYKFAKVMVSKLVRNIGGLILSSNRDYHSATIKGRINGFRQ
                     YKL"
     gene            complement(13580..14737)
                     /locus_tag="KRO40_002099"
     CDS             complement(13580..14737)
                     /locus_tag="KRO40_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide polymerase"
                     /protein_id="HBH2092917.1"
                     /translation="MKTLNDDRNIMIRKYLYIFVLFIILLRKYMISFIDPNMDIGMIK
                     SALFYSSIGILMLLFLFDKRKSITEMVLVGVCVLLYLLNREGAILLIVLLAVSAKQID
                     DKFIVKNYLIISACFLMVAILLFNLFPSLIFNQEVHYRYIEKIDMLVTRMDFGLGNPN
                     SVFYHMVTIYAAYIFLRYKDYNKWDRILLFGSAFFVYQTTYSRTGFFTILAGLIFVEI
                     IRWIDIKKIKGLPMLLKTLPVILTLFSVIIGTVFDKSTLLNRLLASRPKFWNVYLAEK
                     GNFLKPFGNSYSPAIKATNPLDSSYVYIISVLGVVACILFMYLMYKGIESFIEKDKKA
                     YLVALFIFLLYSFAENLLLEASFSFAVVLLIKEVILNDKREIDLWKMKSRR"
     gene            complement(14753..15475)
                     /locus_tag="KRO40_002100"
     CDS             complement(14753..15475)
                     /locus_tag="KRO40_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBH2092918.1"
                     /translation="MIPKKIHYVWFGGPKGNIENICINSWKEKLPEYEIVEWNEKNFD
                     IEKEIKGNKFLEECYKRKLWAFISDYTRIKVLYEQGGVYMDTDMQILKDITPLLENNR
                     LVCGYEDDREYINGAIIGVEKGHPFLKDLLEYYEKEVLTSSLFTIPKIMTHLMEKNYK
                     KIDPNNYEEGIRVYDKEYFYPFGFKEDFTPECITENTFGIHWWGKSWAKKRNYFLESK
                     HLTGVNKIWKCCKIFASNTLRS"
     gene            complement(15487..16560)
                     /locus_tag="KRO40_002101"
     CDS             complement(15487..16560)
                     /locus_tag="KRO40_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="HBH2092919.1"
                     /translation="MKVYNVIMAGGGGTRFWPLSRQEVPKQLINLSGEDALINETINR
                     IDSLAKKDDLFIVTNEKQLEALKDIVKDKCLDSNILPEPCARNTAAAIGFAAFNIMKK
                     YGDGVMCVYPADHYIKDEKEFKSILEKAIYIAENNDKLVTIGITPTFPSTGYGYINFN
                     RENTIEDVAYEVVEFVEKPNYEIAKEYVNSKKYVWNSGMFVWKVSKILEDFKRYLPKV
                     YEKLEDISKYLGTKEEMEKIKEIYPTIQSISIDYGIMERSNDVIVVPGDFGWNDVGSW
                     DSLGAIYPTDDEGNIKRGENITIDTKNSIIYSDDKLISTIGISDLIVVSTNDAVMVCR
                     KDKAQDVKKIVEQLKEEDRQEYM"
     gene            complement(16582..18288)
                     /locus_tag="KRO40_002102"
     CDS             complement(16582..18288)
                     /locus_tag="KRO40_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBH2092920.1"
                     /translation="MDYKNNYEMWLNSPYFDEQTKNELLSIKDDEKEIQDRFYKNLEF
                     GTGGLRGIIGAGTNRINIYTVRRATLGVLNYIMKTQGEEGKQKGIVIAHDSRYMSREF
                     CIEVAKTLSAYGVKAYIFEELKPTPELSFAVRYLKCAMGIVITASHNPKEYNGYKVYD
                     SDGGQICIDMANDIIAEVNKIDDYSTIKSIDFEEALSKNLITILDNEVDDEFIKAVKK
                     QVLRQNIIDEYGKKLKIIYTPIHGTGNKPVRKVLNECGFENVMVVKEQELPDSNFSTV
                     KYPNPEEKSVFNIAIEMAKNNGTDLIIGTDPDCDRVGIVVKDSSGEYVVLNGNQVGSL
                     LVRYILESLVEENKLPKNNPTIIKTIVTSELGAKIAKAYNVDCLNTLTGFKFIGEKIK
                     AFEESNDRSFIMGYEESYGYLIGTHARDKDGVVSSLMICEMAAYYSSKGMNLYEALID
                     TYNKFGYYKEDLKSVTLKGIDGIKKIKEMMLYFRSVKIDNVADVKVDKILDYKDGVDD
                     LPKSDVLKFLLEDGSWIAIRPSGTEPKIKFYFGANSDNQEDVEFKLNNLISYILNVVD
                     SI"
     gene            complement(18334..19890)
                     /gene="murJ"
                     /locus_tag="KRO40_002103"
     CDS             complement(18334..19890)
                     /gene="murJ"
                     /locus_tag="KRO40_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBH2092921.1"
                     /translation="MSKTAKAALWIMAATMFSKVLGFLRELVLANFYGTGMYADVFVL
                     TLNIPGLIIAVIGSAVATTYIPMYFETKKRLGDEGALKFTNNVLNICYIMAIVIAIIG
                     LLFTEQFVTVFAAGFRNDPAKFQAAILFTKIMISGVLFLSGSKIFSSFLQVNDSFVIP
                     GLIGIPYNIIIIAAIALSAGKNVWILPAGALLAMASQLLFQLPFAFKKSYKYKPYINL
                     KDESIKELVNLVLPMLVGVAVGQLNIFVDRLLATTLGDGKLSALNYANRLNEFVMALF
                     VTSIITVIYPKLAKMSGKDNKEGFISTIVKSSNCIILVVLPISIGAIILAEPLVRILF
                     QRGKFDALSTDLTSIALRLYSLGLLACGVRDVLYRAFYSLSDTKTPMINGSIALIINI
                     VLNLILIRPLGHAGIAISTSTSNIITVILLFISLKKKNGYFGGDKIIKTGLKSLVASG
                     VMAVATLLIYNNLYAFMGSGTIKEIISVGAGVLGGASVYTVLIVLFKVEEMDLAFEFL
                     RKGKQKLLRR"
     gene            complement(20005..21060)
                     /locus_tag="KRO40_002104"
     CDS             complement(20005..21060)
                     /locus_tag="KRO40_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp7"
                     /protein_id="HBH2092922.1"
                     /translation="MIKKISTILSLVLLISISSTIGVFADANPKRELIEGSIPEISTE
                     LNKRAFKDSKEVILVNEESIVDSISATPLAYAKNAPIVVTKSKNLGRVTRNYLKELGP
                     EKVTIVGGLKAVSKDAERNIEKMGMKVERIRGKDRYDTSLKIAREMYRTVGFDEAFLL
                     SSTTGLENAISVYSYAAKSGMPIIWAKDEGFEEQIDFLKGKNLKKIYALGDSKEFIAE
                     IDSNLKNIEGIKQINKSSTNVDLIKKFYDEKDIKKIYTARLDFGSRSDVNEYISLGVV
                     SAKENMPILICSDNLSRAQDKFLKDSNINDVVEVGYTVGDYSLFKSIFNLTFLSCIVL
                     ILLLLLITFRALRYESK"
     gene            complement(21155..21841)
                     /locus_tag="KRO40_002105"
     CDS             complement(21155..21841)
                     /locus_tag="KRO40_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HBH2092923.1"
                     /translation="MSGYTNDECEIPKIKSYPGADKEIASEIDYSIVKGTVLFDLYQR
                     IMDLVLSIIGLVIGLPLIAIFGILIKIEDKGPITYKQERLGKCGRRFYIYKLRSMRTD
                     AEKFGAQWAEKDDPRITKVGKFIRKTRIDEIPQLFNILKGDMGLIGPRPERPNFTVQF
                     NEEIPGFINRLAIKPGLTGWAQVNGGYEITPEEKLKEDIYYIKNRSILLDFKILFKTV
                     KVVLTGDGAR"
     gene            complement(22061..24085)
                     /locus_tag="KRO40_002106"
     CDS             complement(22061..24085)
                     /locus_tag="KRO40_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2092924.1"
                     /translation="MKKTTKLLATGMLSVAMVAPNVALAAENTTANTESNSDININLQ
                     RKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKD
                     PEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEY
                     MRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDA
                     PILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVD
                     RHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQG
                     TYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKT
                     FYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHNTNLSEKTAET
                     VYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLN
                     GGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIH
                     YNASNGAGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDY
                     LYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK"
     gene            complement(24339..25451)
                     /locus_tag="KRO40_002107"
     CDS             complement(24339..25451)
                     /locus_tag="KRO40_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5009 domain-containing protein"
                     /protein_id="HBH2092925.1"
                     /translation="MNSRIKSIDIIRGLSIALMIVCNNPGTWMRMYPQLRHAVWHGVT
                     LADFAFPFFVISLGVTIPISINSKLKNNKSTLSIILSIFKRSILLILFGFFLNYLGNP
                     DLDTVRILGVLQRMGLVYFVTSLAYLLLKKLNVGSTATIITFLYIATFIIVGYYILAK
                     PYGFELEGSLAQLVDLHFFKGHLYKPEFEPDGFLTSIVAISSGMLGCTMGCVLLKENL
                     GEYKKFFKILVMSIILLIGAFIFNQYFPFNKRLWSSSFVLLMAGSYGILLSIFYFICD
                     IKNKSKIFTPIIALGSSPIFTYMCLEILSHVFWNVPKLTNKVDYPTTLVEWTTYELIT
                     PWAGTTWDSLIFSLLYVLFWVIVMSIMYKKKIFIKI"
BASE COUNT         7955 a         4634 c         2761 g        10132 t
ORIGIN      
        1 aggtcgataa attttcttat aaattatatc attgtctttt ttttgtaact gaaacaagta
       61 ttgaatatat ctcaatactt taatataatt aagtgtatgc tattaaaaaa tatacaggaa
      121 aaagaagaaa gaaggggtac ttttgtcaaa attaaagaaa tttgttatac tactggcttt
      181 cttggtagta atattcccta taagtgtcta tggatatttt tattataaat tatctgctat
      241 tcatgactcg agcataagta gtgatttatt ggataacaat gaccataaaa atgaagatgg
      301 gataattaac atactactta tgggaacaga tgctagacca aatgaagatt cttcaaggtc
      361 agatgctatg atgatactta ctattgataa caaacacaat gatatcaaac ttacatcatt
      421 agctcgtgat agctatgtag acatccctgg tcatggtaaa caaaaactta ctcatgctta
      481 tgcttatgga caagctgatt tattaataca aacaattgaa gagaatttta atattgatat
      541 tcaaaattat gcttgtgtta atttcgaatc atttatgtat ataattgatg ctattggtgg
      601 cgttgaggtt actgttgaaa aaggagaaat acgagaacta aataaattta ttcctgaaac
      661 ttataaatgg aataaaagtg atgataaagg tagcatacaa tacattagaa actctggaaa
      721 gcagactcta aatggatatc aggcactatc ttttgcacgt atcagacaca acgatacagc
      781 ctttgctaga gatggcagac agagacagat tatacaagct ataatcaaga aaacggaaac
      841 tttacctgtt actaaatatc caggtttatt agatgcagtt cttccatatg ttaaaactaa
      901 catgaagcct aatgcaatac tttctttagg agctcaagtt ttaaaaatgg gcgacttaaa
      961 tattaagcaa tttgaatttc ctattgatga tgaaattcat agtacaggtg gtatatatgg
     1021 aaaagctgga tgggttctta gatttgaccc agatacttta gacatattac acgattttat
     1081 atttaatgac atagagttta aacaataaaa aattcaacat aaagtttatt aaaaagtata
     1141 agattaatta ctaaaaaaga actatatcgc ataattattt tcaagttgct gtgtacactt
     1201 gattacaaaa tgcatatagt tcttttttat tttctaattt atcatgataa ttttcatttt
     1261 aatctacatt tataaaatac tctgtatttt aaattaactt ttttattact taactaagtt
     1321 taagaaagtg tttaatgtgt tttgatttat accatctcca gcttcgtata ctagagtagt
     1381 tttcttaggc tctaaagcag ttttctgagc agatgttaca ctatttccaa gcataactac
     1441 tggtgatttt aatttagctg ctaaaggacc tgatgttaat gcatctacca attgattact
     1501 tttacttaca aacattgatg aatattcagc atttggatag aatttttgta ttacttttcc
     1561 atttgtttct tctctatttt ctccagctat tctattttta gatacatcat ttgtaatgac
     1621 cttatccagc ttatttatta ctgaatcaga tatacttaga ttaccaccta taaaataagc
     1681 atcttttact tttaaatctg atatccaatt gtaaacttca tcacttacat tatcttttga
     1741 tactaatact attggttgct tttcttctcc tgcttttgaa gctatagaaa gagaatctgc
     1801 ttcacctgta ccacttgtta tatatagttt ttctactgga ttagttttta ctaattcttt
     1861 tgctatcatt aaagatgtac tatatctatc tgaaccacca actctattta ttgatacatt
     1921 tgacaatgta tcttttatct cactctcaac tttatctcca atagagttat ttcctccaat
     1981 taaaataact ttacttggat taagtctttt taactcattc ttagtggatg taggtatatt
     2041 atccttattt accaatagta taggagcatc atttgatgta gcaagtggtg ttgatgttat
     2101 accatcaact atagagtacc catttactaa tactactgta tctgaatttg tagcccaacc
     2161 ttttttactt attgctactg ctgtgtcata tctttcgtcg cctcttaatt tctccacttt
     2221 aacattagat ggtggagtaa ctggttcttc actactagaa tataaactct ttaaatcctt
     2281 ttgtatagaa gtactatttg ctatatcttt agctgagaaa tacatactac cttttatttc
     2341 actatacttt ctatttaatg ttacttgttg tactatttct tttgctatat tttgtccacc
     2401 ataactcgat tgaccttgct tatatatacc ttgtcctatg tataagtcta catttgttcc
     2461 ttttacttca ttagcccacc atgccactaa tttagaataa tctgctgctt taagaccaat
     2521 tggccagtaa agttgtggaa ctacatagtc aatcaatcct tgttttatcc atgctcttgt
     2581 atctgcatat gtacctacat aactttcatt acctgatgta tctgaacctg ttgggtcact
     2641 actcttattt ctccatatac ctgctgggct tacaccaaat acaacattag gctttatact
     2701 ctttatagac gcttttacat ctctaagtag agtatttaca ttttctcttc tccaatcatc
     2761 cttattttgt ccttttccat atttttggta tgttgcagta tcattgaaac ttactcctgg
     2821 atagaagtaa tcatcaaaat gaactccatc tatatcgtaa ttttgaacta cttctgctat
     2881 actatccact atgtactttc taacttctgg taaacctggg tcgtagtaat acttatttcc
     2941 atgtttaact acccagcttg gatttttctt tgctggatgg tttgctggca atttatctat
     3001 gctctcatct gccatagtta ttctatatgg attaaaccat gcatgaaatt ccattcctct
     3061 tttatgtgct tcttctatta aaaatggtaa tgggtcatat ccagggtctt taccttgtgt
     3121 accggtaaga tattcagacc atgggtttat atttgattta tataaagcat ctgattttgg
     3181 tcttacttga accactgctg tatttattcc tacacttttt aatttgtcca ataaatctgt
     3241 gtattccttt ttttgcttgg cttcattatt cttagtctta ggccagtcta aattataaac
     3301 tgtagatatc caagcagctc tcatttcctt atcatttgat gaatcagcaa atgaacttac
     3361 actacacata gtaagtgtca ttatcaatga taatactaat atacttattt ttttcatttc
     3421 atccccctta attttttaaa tttatttttt ctacaatata cttcttatta agtatatcta
     3481 aaattcatat tatctgtcaa atattgaata atatagttaa aatttatatt tgatatttga
     3541 ttataatatg aaataattta ttataaaaaa aacagcaaag aaatttatct tctttgctgt
     3601 ttttataacg ttcatcacta ttttaatatt actaaactct taaatctcta tgtaaaacat
     3661 taaatgtaat tatatattta atgttaatat tcaatcctat gtaaatcaat atctattatt
     3721 attgtaaaac acgtgtagca gttataagtc tttttgcata attagttcct ggagccatgc
     3781 tagtaacttt tactacatct cctgtttgtg gtgaatgtat gaatttagaa tctcctacat
     3841 acaatccaac gtgatttatt gaaccacctg aaccaaagaa aactaaatct cctggtttta
     3901 attctgctct tgatactttc tttcctactg ttgcttgtga tcttgatact cttggtaaat
     3961 taactcctgc tccattttta tagacataag aagtgaaccc agaacaatca aaagaatttg
     4021 gtccagttgc tccccattta tatggcttac cttgttgctt aaatgctaag tttaaaacat
     4081 tttgtacctt tgcatctaca tttccacctt gaatagttaa ataatctcca tttacccatc
     4141 ctgtaacatt gtcaacactt tttattttaa tccatccatt tgaatgtaat tctaaaactt
     4201 caactttgtc tcctgtgttt atctttccta ctactgcatc atttgcacta gctccacttc
     4261 ttacatttaa aaaatcacac tggtctactg ttgcactcat aggtgaatta gttggctctg
     4321 ctgcactagc cgttattgct cctgcttcta ctgtgacaac tcctgctatt aacaccatag
     4381 ctataaattt tttcaatata tgttttttat ttttaatatt catcataatc tcaaatacct
     4441 aatcctttcg aaaatttaac attttgttcc ttcgtttcca attcctaatt aacattctat
     4501 cttacatcaa aataaattgc aacctttttt gtaatctttt tgtaatcttt ttgtaatctt
     4561 ttgtttcttt ttagtatata tttgtttctt tttgctcccc ctggttacaa attagaaata
     4621 tattctactt ttctctagtt gttgcaattt ctttgatatt agcatcttct ggtttaatat
     4681 aagttggtac taattccctc ataataccat ctattttttc aacctcttca ttgttagtaa
     4741 tttctcttaa aagttttaag tattttgtta ttttttctct atcaacatct attggtctac
     4801 caataaaaat ctttttatgc tctgtatcca atagaccttc ttctgacata agtagttctt
     4861 catacaactt ttctcctggt ctaagaccag aaaattcaat ttttatatca acatctggct
     4921 caaatccact gaatttaatt aagttttttg ctaaatccaa tattcttaca ggttctccca
     4981 tatcaagcac aaatatttct ccacctttag ccatagcccc agcttgtata actaagccta
     5041 ctgcttctgg tattgtcata aaatatctaa taatatctgg atgagtaact gtcactggtc
     5101 cgccatcttc aatttgcttc ttaaaaagtg gaattacact accattacta ccaagcacat
     5161 ttccaaatct aacagcaaca aattcagtct ggctttcagc attcatagtc tgtataatca
     5221 tttcagcagc tcttttagta gctcccatta tgttagtagg gtttacagcc ttatctgtag
     5281 atataaggac aaatttctta gctctatatt ttgaagacaa gccagctatg tttaaagttc
     5341 caaatatatt attctttata gcttcgccag ggctcgattc cataagagga acatgtttat
     5401 gtgctgctgc atgaaatacc acttctggtt tatatttatt aaatatttca tccattcttt
     5461 tttcttctct tattgatgct attactgtct tcaaatctaa tttattttta tattttctaa
     5521 gtaattcttg ttgtattgag taagcattat tttcataatt atcaactata ataagctctt
     5581 taggattaaa tcctgcaatc tgtctacaaa gctctgaacc aattgagcct cctcctccag
     5641 ttattaggat tacttttccc tcaatgtaat tacttatctc tcttaaattt gtttttatag
     5701 gctctctacc caacaagtct tctatctcta cttctctaat ctgttttata tcaacttttc
     5761 catctataat ttcgtaaatt cctggtattg tctttatttt acagttagtg tttttacata
     5821 tatcaataat atcttttttt ctacgtttct ctatgtttgc tattgaaaag attatctcat
     5881 ctacattgta cttttctacc acatctttta tatctgaagt tgttcctaca attttcacat
     5941 tatggattat tcttccaatt ttatttttat catcatcaat tatagccact gctacttttt
     6001 taagttctgg atttcttttt agttcctgta taaccatttc tcctgcatct cctgcaccaa
     6061 ttataaggat atttgaaacc tttcctctag aatatgtctt gttcatgact attcttatag
     6121 ctctataggc tattcttgcg ccacttgtaa acattataat aaatattgta tttaatacat
     6181 aaaacattat aggataatca aaccctaata atttatttat tatataaatc ggaattaaat
     6241 aagctaaagt tgccacaaaa atagatataa tttcttcttc tcctgcatat ctccataatg
     6301 tgttgtagca cttaaacaat ctaaatgata ctatatgaag tactatatat atacacactg
     6361 aaattattat atcattagtg gtaaatgcat ttaaattacc tgtcaagctt aaagacattc
     6421 gaaacgctac tagtacgcta caaatatcta gaattaatag tgttaaatgt ctaaatttat
     6481 attttttaaa aagcctatta aaaaagcttt ctttctctaa atctatactt tctcgcataa
     6541 ctagaagccc tcctttaaac agcaaaagct acgcacctaa gcatagccaa caacatctat
     6601 cttttgctgt attttttcat tttatttttt atatttatca aatatagaat cataaatttt
     6661 ttctatatca ttaaagttta aattaacctc ataattttct ctaacaaatt gacgcccttt
     6721 cttacccata ttaagtctaa gttcatcatt ttccattagt tttattatag cattttttat
     6781 ttcttctggt tgttttggtt ctacaattaa gccagtttca ttttcccata cagattctgg
     6841 atgtcctcct acatttgtaa ctataacagg tacttcacat gcttctgatt ctatagctgc
     6901 cactccaaat ccctctctta aagaaggaaa tacagttaca tcaaaagaat taaaagtctt
     6961 gcttacattt tctggagata ttcttcctaa aaactgaaca tcattttcta tacccaattc
     7021 tttagctaaa tttattaggt tgtccatctg acttccagag ccacctattt taagaattat
     7081 tttcttatct ttatattcat ctttaagcat cttaaatgct tgtattaaat attctattcc
     7141 atattttttt tctaaactct ttataattcc tattacaaaa gcgtcttctt tttctacttc
     7201 cataggctta aacctatcca tatctactcc aaaaaaggtt acatctacat gtttagctgt
     7261 atatttatta gcctctttag ccatatctct actatttgaa aagatatagt ctgcttttct
     7321 aaagttatgt tttataattt gtttttgtat aaaaccatta ttagggaaat cataaatatc
     7381 agtaccccaa acagaaataa tatatggatg atacccaagt agacttccta taaatccata
     7441 actacttgca tactgtgcat gcaatatatc tggctttatt tcatttacta gcttctttat
     7501 ctgctttatt gaacctaagt atcccgtttt tttagaaata ttttcatttt ttagttcttc
     7561 tacattagaa ccaaaattat aaatttttat tccttccatg tgacctccat ttaaagagat
     7621 tacatgaatg tcatatcctt tatttttaaa aaaactacac cattttaaag tatgaggatt
     7681 tgacccatca gctaaataac aaacagtctt cataatattt accttcctat cgaataatac
     7741 tcaattccta actcttccat atctttaatt ttataacaat ttcttccatc aaggactaaa
     7801 ggatttttca tcttttcctt atacttatgt atatcataat ttaatacatc tttccattct
     7861 gtcattataa aacatatctc tgcatcttct atcgcatcat ctacagaatc agcataaagt
     7921 atagagtcac caaatatttt cttagtatta tttacaccaa ttgggtcgta tacagtaact
     7981 cttgcccctc tttcgagcaa atattttata tttggtatag atggtgcttc tcttatatca
     8041 tcagtgtctg gcttaaaagt caaacctaaa acagcaacct tcatatcttg aaagctctct
     8101 actaacttag atgcctttct aactaattta agtttttgac tttcattaac ttctattgca
     8161 gcttttactg tttttaattc ataaccatta tgttcagata accagtgaag agcttttgtg
     8221 tcttttggaa agcaagaacc accatatcct attcccgcct ttaaaaactt acttcctatt
     8281 ctatcatcat aactcattcc taaagctaca tcttctatgt tagctcctgc tatttcacaa
     8341 agatttgcaa tatcattcat aaatgatatt ttaagagcta agaagttatt tgatgcgtat
     8401 tttatcatct cagcactatt tctatttgta actattatag gttgattaaa aggcttatag
     8461 atttcctcta atatttctct agcccattca ctttctacac ctataacgat tcttgaagca
     8521 tgtagagtat cttttactgc tgttccttgt gataaaaact ctggattaga tgcaagttct
     8581 acttttacat cattttttag gtttctattt atataatctt ctatctcttc atttgtacca
     8641 attggaactg tagattttat tactactaga gtatcttttg tcacagtttc agctatttgc
     8701 tttgcaactg cctttatata atctaggttg gctgaaccat cacttctctc aggtgtacct
     8761 acagctatta atattacatc tacatcttca taagcttttt tatagtctgt agtgtaatct
     8821 attcttcctc tgttgtaatt tttaaccata agttcttcta ggccttcttc atatataggt
     8881 gctattccaa gtttcattga tttaactttt tgttcatcta catcaacaca gactacattt
     8941 tcattgccta cctctgctag acaaacacct gtaaccaaac ctacatatcc cgtcccagct
     9001 atagctattt tcattttttt acctccaagt atataaaact tatactcttt ttttaatggc
     9061 attaaaaaca tagaaacaaa atacatatag actttttggt aaacttaaat tttcaacatt
     9121 tctataagta ttccaagttc gttttaatgc ttttatcttg ttacttgata tagaatttcc
     9181 aactaatctg taattcacta aatcttcttg aatcccatat gcatattttt cctttttaag
     9241 taactgtaac caggttgcag tatcttgtcc tcttcttacc aaaggcatgc tgaactctcc
     9301 tacaatctcc ttatcaatga ccactgtaga acatcctatt atagtatttc taagtaatcc
     9361 ttcatagtca attttcttag gagctcttgc aaccttattc gtttttgacc catcttgtct
     9421 catatatcta taagatgtaa aagaaaaacc tacattttct tttaacatat attctatctg
     9481 aatctctaat tttctactat cccataaatc atcactatct acaaatgcaa taaatcgacc
     9541 ttccgcattc ttaataccaa catttctaga tactgcagct ccagaatttt tttcaagctt
     9601 tatatatttt attctagcat cttcttttcg aaaacttttt ataatttcac ttgaattgtc
     9661 cttagaacaa tcatccacta ataaaagctg ccaattttta taagtttgat tttggattga
     9721 ctttatcgtc tctgataaaa actcttctga attataaaca ggagtaatta tcgatactaa
     9781 aggctcattc atatttttac tctccttata tagcaactag cagtactata ccaacaagtt
     9841 tacttagata ctaattttct ttgtccaata tatttgtaat atcctaatgg gaataatgct
     9901 aaatacaaca atttatcaga tacttttctt aattcaccaa aataatgact atcagacaac
     9961 aatgagtatc tggctaaatt tatgtaattt tttatccaca tatatggata tctacttaat
    10021 ggatatgtat tttgatttat taaatataaa aactctaatg ctctacctct taatgcattt
    10081 ttacttaata tattcttagt caaaccatca tccaaataat ctcttattat cataggttta
    10141 tttacacata taactttata gtatttagac atttcattcc atactacact ttctggtaaa
    10201 aatctcactt cttttctttc tggaaaagga aattttataa gctcatcagt tacaaatact
    10261 atgcttttat ctcccttaac gccatactta aaatataggt ctgcaaagtg acatattttc
    10321 ttatcttcag gcatttctgt ccctatcaaa tctccacttg gatatacaca aagtccaaca
    10381 actccactaa atccttcttt attctctaaa gaatcccact catcattagc aatttcaaga
    10441 gaatctttaa ttaaaccatc atcactatct acaatgaaaa atagctctcc atctgcattt
    10501 tttacaccta gatttattgc agtatgtttt cctccatttt ctttgtatat atatcttata
    10561 tttaatttat tttctgatat aaatttttca actaactctt tagtactgtc gctacttcca
    10621 tcatcaacaa tcaaccattc aaaatcattg aaatcataag tttgagcttt taaatcattg
    10681 tacaaatttt caagtaaatg agctctgtta tacgtcggag taaatacagt aaatttatat
    10741 ttatacatta attaaatctt cctctctgtc taactttttt tgattccgtt tattccataa
    10801 ttaataaagt agtatatagc tttgtataaa ggtatttttt ctatatttct atatatattc
    10861 caagtccaca tagcagcttt tattttatta ccacttaggg aattgctaga ttttctatat
    10921 aatgctagaa cttcatttat tccatgagca atatgccctt ttttcaatat cgataaccat
    10981 aaaacataat cttcatgtct tacaccactc attcttattt caaaatccaa tttagactta
    11041 tcaatcacaa cagtaagaca tcctaagata tttcctttta ataatcttct ataatctaca
    11101 ttaggtggaa cttttattac tttgtttaat tttttatcat tttcatccat cagttcatat
    11161 gaagtaaatg aaattacata gtcattttct aacataaaat ttacttgttt ttctaactta
    11221 ctactattcc attggtcatc actatctaaa aaagctataa attgtcctgt tgccttactt
    11281 agtgctaaat ttctagcatt agagacaccc ttattagtct cagtctttat acattttatt
    11341 ctactatcct gttgcatata agatttgact atattaggac tattatctgt tgagcaatca
    11401 tcaataatta acatttccca ttcttgataa gtttggttta atactgattt tatggttgct
    11461 tcaataaatt tttcagaatt atacatggga gtaattatag atactaaatt cttcttcata
    11521 ttaccttcct catcatttat aaaatattta tttaatttta cttaatacac aatcatatat
    11581 cctcttgcag ttcttattat cattatatct gaaaaactta tttctttcat ttttttggtt
    11641 atccataacc tcaaaattat tttcaataat atcaataagt ttattcacgg cttcatcatt
    11701 attataagcc aaagacccaa acatttcact ttttaaatct atatatgaat caactttttc
    11761 catatattca tccaaatcga attggtaaaa caagataggt ctattcatat acaaaaagtc
    11821 tatggctaca cttgaataat cagttatatt tgcagctgat tttctgattt catttgctag
    11881 agttacccct ttatctaaaa acacaattcg ttttcctgtt atattttctt ttatatcatc
    11941 tataaactca tgcataagat gatgcatata aatttttaca tttatatctt tctcatctaa
    12001 tattttattt aatttgtcat catttaaaaa attcattata tttttaaaat aatctgtatc
    12061 cgtaaatttt cctgaactaa attttatcca atctctccat gtaggagtat ataatatatc
    12121 tcgagtttgt gcaacttcat ttgttggtaa attgtcatat cttgcatttc caattatata
    12181 aactgagtca tctaacattc cccaatcatt taccataaca tttctttcaa attcagaact
    12241 tgctgtaact atattatagc ttttatatag gttatctata atatttttga actttttgtt
    12301 cataggtttt ctttttttaa aacttatagt cccatgattt aaaaacactt ttatcgtttt
    12361 tttatgaaaa taattaagaa caggtacagc aaaattgtat ggtgctatat ctgctgatgg
    12421 tgcatgtgaa aatactatag cttttgaatt gtaataatac agatagtttt ctacacttcc
    12481 tcttattaat tttttgcctg gaattttatc aaatacttta ctgtctttat ttactaccca
    12541 ataagtttct acatcattat gttcttttag catatactca taaaaaaact ttgaattatc
    12601 attgtatata tcccctgaat gtccacctat aagccagata tctctaccat taaacttatg
    12661 cttattaaat ggatatataa aaaaagccaa aagcatattt attaaaaatt taaccttgtc
    12721 cataaacacc atcctcatta taacttgtac tgtctaaatc cattaattct tccttttata
    12781 gtggcactat gataatctct attggaactc aatataagac ctcctatatt tcttacaagt
    12841 tttgatacca taacttttgc aaacttataa ttttttctat agactatttc ctttttgcaa
    12901 agcgctccaa agcctcttcc atagttataa tctttttgat acttttcttt agatttagaa
    12961 tgtttttttg caggatggta aattatatca tttccaaagt attttccttt aaaacctaaa
    13021 ctcaataagt ttaaaacata atctatctct tcaccagcac caaactctcc accaacaccc
    13081 aatttttcat caaatcttgt atagtcttta ccttcaaaat caataaaaaa agttatggat
    13141 gttatagtat ccaaaacgtt ggaacttgtg atatcacaag ttccatcata cattttctta
    13201 aatgcatcaa ctttatttga atccatagtt ttgcaactgt atattttata atctttattt
    13261 ttattaaaga aatttataac tttttctaat gtatcatttt cgtagacaca atcatcatca
    13321 gggaaaccta taatttgccc tacagcattg tctatgccta catttctgtt ataactcaat
    13381 ccttttttag agctttttat atactttata tctaacttat caatgtattt atcaactatt
    13441 tctttaactt tgctattatc attttggtct actactataa gttcaaagtt tttgtaagtt
    13501 tgattttcta agctgtccat aagtaagtat atatcatcat atctatttaa tgttggcatt
    13561 attaatgata ttaacattac tacctcctac ttttcatctt ccacaaatct atttcccttt
    13621 tatcatttaa tatcacttct tttattagta atactactgc aaaactaaat gaagcttcta
    13681 ataataaatt ttctgcaaaa gagtatagta aaaatataaa taaagctact aaatatgctt
    13741 ttttatcttt ttctataaag ctttctattc ctttatacat caaatacata aataatatac
    13801 aagcaactac tcctagtaca ctaattatat atacataaga actatctaat ggattagttg
    13861 cttttatagc aggactatat gaatttccaa aaggttttag aaagttcccc ttttcagcca
    13921 agtatacatt ccagaactta ggtctacttg ctaataatct atttaataaa gtgcttttat
    13981 caaatactgt accaataatt acactaaata aagtaagtat taccggtaat gtctttagga
    14041 gcattggtag tccttttatt ttttttatat ctatccatct tattatttct acaaatatta
    14101 atcctgctaa tatagtgaaa aatccagttc tactatatgt ggtttgataa acaaaaaatg
    14161 cagaaccaaa taaaagtatt ctatcccatt tattataatc tttatatctt aagaatatat
    14221 atgctgcata tatagtaacc atatgataaa atacactatt tggattacca agtccaaaat
    14281 ccattcttgt aacaagcata tctatttttt ctatatatct atagtggact tcctgattaa
    14341 atattaatga aggaaataaa ttaaataata atatagctac cattaaaaaa catgccgata
    14401 ttattaaata atttttaact ataaatttat catctatttg cttagctgat acagctaata
    14461 aaacgattaa taatatagct ccttccctat ttaataaata aagtaagaca caaactccaa
    14521 ctagtaccat ttctgttata ctttttctct tatcaaataa aaaaagtagc attagtattc
    14581 ctattgaaga ataaaataac gctgatttaa tcatccctat atccatattt gggtcaataa
    14641 atgatatcat atactttcta agtaatatga taaacaaaac aaatatataa agatattttc
    14701 taatcataat atttctatca tcatttaaag tcttcatttt actttctccc ttttagcttc
    14761 gtaaagtatt acttgcaaat attttacaac acttccatat cttatttaca cctgttaagt
    14821 gtttgctttc taagaaataa tttctctttt tagcccaact ttttccccac caatgtatcc
    14881 caaaagtgtt ttctgttata cattctggtg taaagtcttc tttaaatcca aaaggataaa
    14941 aatattcttt gtcgtaaaca cgtattcctt cttcataatt atttggatca atcttcttat
    15001 aattcttttc cataagatga gtcattatct ttggtattgt aaacaatgaa gaagtaagta
    15061 cttctttttc ataatactcc aataagtctt ttaaaaaagg atgtcctttt tctacaccta
    15121 ttatagcacc atttatatac tctctatcat cttcataccc acagactagc ctattatttt
    15181 ctaaaagagg agttatatcc tttaatattt gcatatctgt atccatataa actccacctt
    15241 gttcatagag tacttttatt cttgtataat cagatatgaa tgcccaaagt tttcttttat
    15301 aacattcttc caaaaactta tttcctttta tttctttctc tatatcaaag tttttttcat
    15361 tccactctac tatctcatat tctggaagct tttctttcca agaatttata catatatttt
    15421 ctatatttcc ttttggacca ccaaaccata cataatgtat ttttttagga atcaaatgaa
    15481 cacctcctac atatattctt gtctatcttc ttcttttaac tgctctacta tttttttgac
    15541 atcttgagct ttatcttttc tacaaaccat aactgcatca tttgtagata ctactatcaa
    15601 atcactaata cctattgttg atattaattt gtcatctgaa tatataattg aatttttagt
    15661 atctatagta atattttcac ctcttttgat attaccttca tcatcagttg gatatattgc
    15721 acctagagaa tcccaagaac caacatcatt ccatccaaaa tcaccaggaa ctactataac
    15781 atcattactt ctttccataa taccataatc tatagagatt gattgtatag ttgggtatat
    15841 ttcttttatt ttttccattt cttcttttgt tcctaagtat ttacttatat cttctaattt
    15901 ttcatatact tttggcaagt atctcttaaa atcttctagt attttagata ccttccatac
    15961 gaacattcca ctattccata catacttttt agagtttaca tattctttag caatttcata
    16021 gtttggtttt tctacaaact ccactacctc atatgcaaca tcttctatag tattttctct
    16081 attaaaattt atgtatccat atcctgttga tggaaatgta ggagttatcc caatagttac
    16141 tagtttatca ttattttctg ctatatagat agctttttcc aaaatagatt taaattcttt
    16201 ttcatctttt atataatggt cagctggata tacacacata acaccatcac catatttttt
    16261 cattatgtta aatgctgcaa agcctatagc tgctgctgta tttctggcac atggctctgg
    16321 caatatatta ctatccaaac atttatcttt tactatatcc tttaaagctt ccaattgctt
    16381 ctcattggtt actataaata aatcatcttt ttttgctaga gaatctattc tgtttatagt
    16441 ttcgtttatt aaagcatctt ctccacttaa atttataagc tgtttaggta cttcttgtct
    16501 actaagtggc cagaaacgag ttcctcctcc tccagccatt atgacattgt atactttcat
    16561 tgtttatctc cccttagctt tttatataga atccactaca tttaatatat aagatattaa
    16621 attgttcaac ttaaattcta catcttcttg attgtctgaa tttgctccaa agtaaaattt
    16681 aattttaggt tctgtacctg aaggtcttat agctatccaa gagccatctt caagtaaaaa
    16741 tttaagtaca tctgacttag gtaaatcatc aacaccatct ttatagtcta aaattttatc
    16801 tacttttaca tcagccacat tatctatttt aacacttcta aagtaaagca tcatctcttt
    16861 tatttttttt attccatcta tgccttttaa agttactgac tttaagtcct ctttgtagta
    16921 tccaaattta ttatatgtat ctatcaaagc ttcatacaag ttcatacctt ttgaagaata
    16981 gtatgctgcc atttcacata tcataagtga agatacaaca ccatccttat ctctagcatg
    17041 agttccaatt aagtaaccat agctttcctc atatcccatt ataaaacttc tatcattgct
    17101 ttcttcaaac gcttttattt tttctcctat aaatttaaat cctgttaaag tatttaaaca
    17161 atctacatta taagcctttg ctatttttgc acctagttct gatgtaacta tagtttttat
    17221 tattgtagga ttgtttttag gaagtttatt ttcttcaact aaactctcta atatatatct
    17281 aactaaaagt gaaccgactt gatttccatt taagactaca tattcaccac ttgaatcttt
    17341 tacaacgata cctactctat cacaatcagg gtctgttcct attatcaaat cagtgccatt
    17401 attctttgcc atttcaatag ctatattaaa cactgacttt tcttcaggat taggatactt
    17461 tactgttgaa aaattagaat ctggcaattc ttgctcctta actaccatta cattttcaaa
    17521 accacattca tttaagactt ttcttactgg cttatttcct gtaccatgaa taggtgtata
    17581 tattattttt aattttttcc cgtattcatc tattatattt tgtcttaaaa cttgtttctt
    17641 aacagctttt ataaactcat catctacttc attatctaat atagttatta aatttttaga
    17701 taaagcttct tcaaaatcta tacttttaat agtactgtaa tcatcaatct tattaacttc
    17761 tgctattata tcatttgcca tatctataca gatttgacca ccatctgagt catatacttt
    17821 atatccattg tattctttag gattatgact tgctgttatt actattccca tagcacactt
    17881 taaatatcta acagcaaaag aaagttctgg tgtaggcttt aattcttcaa aaatataagc
    17941 ctttacacca taagcactta aagtctttgc tacttctata caaaactccc tagacatgta
    18001 tctactatca tgtgctataa ctattccctt ttgcttacct tcttctcctt gagttttcat
    18061 gatataattt aaaacgccca gtgtcgcacg tctaacagta taaatattga ttctattagt
    18121 tcccgctcct attatacctc ttaaaccacc tgttccaaac tctaaatttt tataaaatct
    18181 atcttgtatt tctttttcat catcttttat acttaatagc tcatttttcg tttgttcatc
    18241 aaaataagga gaatttaacc acatctcata attattctta taatccatat tttcatcctt
    18301 tctgactcta atttaaaatt tcaaggtaat tatctatctt ctaagtagtt tttgttttcc
    18361 ttttcttaaa aattcaaaag ctaaatccat ctcttctacc ttaaataaaa ctatcaatac
    18421 agtatataca gaagctccac ctaatactcc agctccaact gatataattt ctttaattgt
    18481 tcctgaaccc ataaatgcat atagattatt atatatcaat aaagtagcta ctgccatcac
    18541 accagatgct accaaacttt ttagaccagt ctttataatt ttatcccctc caaaatatcc
    18601 atttttcttt ttaagagata taaataataa tataactgta attatgtttg atgtactagt
    18661 tgatatagca atacctgcat gacccaatgg tcttatcaat attaaattaa gaactatatt
    18721 tattattaaa gctatacttc catttatcat tggtgttttt gtatctgaaa gagagtaaaa
    18781 tgccctatat aagacatctc ttactccaca agccaataaa cctagtgaat ataatctaag
    18841 cgctatagat gtaaggtctg ttgataacgc atcaaattta cccctttgga ataatattct
    18901 aacaagaggc tctgctaata taatagctcc tatagatata ggaagcacca ccaatataat
    18961 acaatttgaa gattttacaa tagtgcttat aaatccttct ttattatctt taccagacat
    19021 ttttgctagt ttaggatata taactgttat tatagatgta acaaataatg ccataacaaa
    19081 ctcatttagc ctatttgcat agttaagagc agacaacttt ccatcaccca aagtggttgc
    19141 caataatcgg tcaacaaata tatttaactg tccaacagct actcctacca acataggcaa
    19201 tactaggttg actaactctt ttatagactc atcctttaaa tttatatatg gcttatactt
    19261 gtaggacttc ttaaacgcaa atggcagttg aaacaatagc tgactcgcca tagccaataa
    19321 tgctcctgct ggcagtatcc atacattttt acctgcactt agtgctattg ctgctattat
    19381 tataatatta tatgggattc ctataagccc aggaattaca aaactgtcat tcacctgtaa
    19441 aaacgaacta aatatcttac ttccactcag gaataaaact cctgaaatca ttattttagt
    19501 aaataatatt gctgcttgga acttagcagg gtcgtttcta aatcctgctg caaatactgt
    19561 aacaaattgc tctgtaaata aaagaccaat aatagctatt actatagcca ttatatagca
    19621 tatatttaaa acattattag taaattttaa ggcaccttca tctccgagtc ttttctttgt
    19681 ctcaaagtac ataggtatat aagttgtagc aactgcagag cctatgactg ctatgattaa
    19741 accaggtata tttaatgtta atacaaatac gtctgcatac atacctgtcc catagaaatt
    19801 tgcaagtaca agttctctaa ggaaacctaa tacttttgaa aacatagtgg ctgccataat
    19861 ccacaatgct gctttagctg tttttgacat cttctttctc cttatctaat ttaaactcta
    19921 aaagtagaac ttttaaaact gcttataaac attattctaa ttaagtaaat ttaacctatg
    19981 aaaagcttcc ttataaatca aaaactattt cgactcatat ctaagtgccc taaatgtaat
    20041 caatagtaat aatagtatta atactataca agataagaat gttagattaa atatgctctt
    20101 aaatagacta taatcaccta ctgtataccc aacttcaact acatcattta tattgctatc
    20161 tttcaagaat ttatcttgtg cacgacttaa gttatcacta caaatcagta ttggcatatt
    20221 ttcttttgct gatactactc ccaaagaaat atattcgttt acatcagatc tactaccaaa
    20281 gtctaatcta gcagtataga ttttctttat atctttttca tcataaaact tctttattaa
    20341 atcaacattt gtacttgact tatttatttg ctttattcct tctatatttt ttaagttaga
    20401 atcaatctct gcaataaact cttttgaatc acctaatgca tatatttttt taagattttt
    20461 gccttttaag aaatcaattt gttcctcaaa cccttcatct ttagcccata ttattggcat
    20521 tccactttta gcggcataag aatatacaga tatggcgttc tctaatcctg ttgttgagct
    20581 aagtaaaaat gcttcatcaa atcctactgt tctatacatt tctctagcta tctttaaaga
    20641 tgtatcatat ctgtctttcc ctcttattct ttctactttc attcccattt tttctatatt
    20701 acgttcagca tctttagata ctgcctttaa accacctact atcgtaacct tctctggacc
    20761 tagttctttt agataatttc ttgttactct accaagattt ttactcttag ttacaactat
    20821 tggagcattt tttgcatatg ctaaaggtgt tgcacttata ctatctacaa ttgactcttc
    20881 atttacaaga attacttctt tagaatcctt aaatgctctt ttatttaatt ctgtcgaaat
    20941 ctctggtata ctcccttcta tcaattctct tttgggattt gcatctgcaa atactcctat
    21001 cgtactagaa atagagatta acaaaactaa cgataatata gtagaaattt ttttaatcat
    21061 aagttctcat tccttttctt ttttgtattt tttgacaata aaaaagctct ttttaaagag
    21121 ctttttcatt gattagtaat ctaatatttt aaaattatct agctccgtct cctgtcaata
    21181 ctactttaac agttttaaag agtatcttaa agtcaagtaa tatactccta ttttttatat
    21241 agtaaatatc ttctttaagt ttttcttcag gagtgatttc gtatccacca tttacttgtg
    21301 cccaacctgt aagcccaggt tttatagcga gcctgttgat aaatccaggt atttcctcat
    21361 taaattgaac agtaaagttc ggtctctctg gtctaggacc tattaagccc atgtccccct
    21421 ttaatatatt aaacagctgt ggaatctcat caattctagt tttcctaata aactttccaa
    21481 ccttagttat tctaggatca tctttttcag cccattgtgc gccaaatttt tctgcgtctg
    21541 ttctcataga tctcaattta tatatataga atcttctccc gcattttcct agtctttctt
    21601 gcttataagt tattggtcct ttgtcctcta ttttaataag aattccaaat attgctatta
    21661 aaggtaaacc tatcacaagt cctattatag ataaaactaa atccataatt ctttggtaca
    21721 agtcgaataa aactgttcct tttactatgc tatagtcaat ctcacttgca atttctttat
    21781 ctgcccctgg atagctttta attttaggta tttcacactc atcattagta tatccagaca
    21841 tagttacctc catattggaa taaaaatttt tttaattctt aatttcaact tatttctatc
    21901 ttatttttga cttatttcta tattatactc aataatgagc agattatcaa tacaagaaac
    21961 atcattgtaa acaatttgat tctttacaaa aatatatcat ctcttgttat attttacatt
    22021 ataacaggag atgatatgtt ttgctttaat attttctatt ttattttact gtatcttcta
    22081 ttcctattcc aatttgagtt cccattgttt ttactttttc tgcagtattt aacttatcca
    22141 tatcgctctt attgtcaata aatgcacatt caacaagtat tgctggataa ttgttatttc
    22201 ttaacacata taggtaatct tttccattat caagtgttct tgtcttgatt cctctatttt
    22261 tcatgttaaa tttttctagt attcttttta agatatttga tgctgcagtc ttagttgttc
    22321 caccattttt atcttttact ttgtaataaa tttccacacc attaccagct ccattagacg
    22381 cattgtaatg tatacttgta aataaatctg gctttatagt atttgataat gctgttcttt
    22441 ctcctaaagc cattgtttta tctgtatctc tagtcataac aacatttata ccttttgaac
    22501 gtaaatattc agtagttgct aatgctgtat taagagtata tttcttttct tgtgctccac
    22561 catttaatcc acttgttgcc cctgaatcag aacccccatg acctgggtct atcactacag
    22621 tttttcctgc tgctgaacct gaattatctg gttctgttgg tgcattgtgt tttgataaac
    22681 tagatgctat agaatttata acactatctt tcattccatc accaatttga tatactgttt
    22741 ctgctgtttt ttctgataaa tttgtattat ggtatgcaga aacataagtt tttggagtta
    22801 taagtattgg agcttttaat ttagctgcta aaggtcctgc tgttattgaa tcaactatta
    22861 tgtcagattt tgcaactaac attgcactca actctttatc tggatagaaa gtcttaatta
    22921 catttgcatt tgtttcatgt ctatctgctc cagaaactct attttttgaa gtaccatttt
    22981 ttgctatttt agatatttgg tctataattt ttgatgataa actttgacta ccacctatgt
    23041 aataagcttc ttctaaacct tgtgaagata accaattata tgtaccttgt ggtacagaat
    23101 ctttattagc taatattata ggttgttggt cttcaccagc ttttgatgaa atattaagag
    23161 catcatattc accagcatat ccatttgcta tgtatatttt attaacatca tgatacttat
    23221 ctatttcttt tgctataagt aaagatgttt catgtctatc aactccacca atacgagtca
    23281 catttacatt tacagcagat ttaatttgag acactgcctt ttgtgaaact gaaccatcat
    23341 cacctataat tattacatca cttggattta gacgttttaa ctctgctttt gtactttctg
    23401 gtatatcatc tttatttgca agtaatattg gtgcgtcata tgtagatgca agtggagtag
    23461 ctgtaattcc atctgctgct aattctccat taactattac aaccttacta gacccatctt
    23521 tccaaccttg tttacttatc tcaacagcag tttcaaatct agtagctcca gcaagttttt
    23581 ttactggtgc agaagttttt ctcatatatt catttactgc ttttgttgaa tttgcatcac
    23641 ttattataaa ctcttgtgta acatcataat ccttaagatt taatcccata gactctaagt
    23701 cttctttgtt taaaactttc tgttcatctt taccatttat ttttatgctt tgaagttccc
    23761 atacatttaa gtattctggg tctttgttat agtttattac accttcatat gaatctgtct
    23821 tttcattgta atttaaagta gcttcaagtg gcatatcata acacataaaa tttaatgtta
    23881 ttgaatcagc atttaatttt tctttaaatt ttacacttgc attagattta cttcctaaca
    23941 ctacactttt tctttgtaaa tttatattaa tatctgaatt agattctgta tttgcagtag
    24001 tattttcagc cgctaaagct acatttggtg ccaccattgc tacagacaac attcctgttg
    24061 ccaataattt tgttgttttt ttcatcatat cccccctaat tttttggttc tttaaatctt
    24121 taaatctttt ttaatacatc ttaagcttgt tttatattac ataaattcaa tattatgtaa
    24181 atcttttttc attatagcac aaaaaattac aaattgtaaa ctttttgtaa tcttttatgg
    24241 catggttttt aaattttatc gaggagaaat tttgattata tttgatagtt tctgtatatt
    24301 tgaacaaatc aaagacttta tcatctaaaa atattgcact aaattttaat aaatattttt
    24361 ttcttgtaca ttatagacat tactataacc cagaatagga catacaataa agaaaatata
    24421 agagaatccc aagttgtacc tgcccaaggt gttataagtt catatgtagt ccactctacc
    24481 aaggtagttg gataatcgac tttgttcgta agttttggaa cattccaaaa aacatgactc
    24541 aatatctcaa ggcacatata tgtaaaaatg gggctacttc caagtgctat tattggggta
    24601 aatattttac ttttattttt gatgtcgcat ataaaataaa atattgacag taatatacca
    24661 taactgccag ccattaaaag tacaaatgag ctagaccata atcttttatt aaatggaaaa
    24721 tactgattaa agataaaagc acctattagc aggattatgc tcataaccag tattttaaag
    24781 aattttttat attctcctag gttttctttt aaaagtacac atcccatagt gcatcccaac
    24841 atacctgaag aaattgctac tatactagtt aaaaaaccat ctggttcaaa ttccggcttg
    24901 tacaaatgtc ctttgaagaa atgtaaatcc actaactgtg caagagaacc ttctagctca
    24961 aatccataag gttttgctaa gatgtagtac ccaactatta taaatgtagc tatatataga
    25021 aaagtaatta ttgtagcagt acttccaaca tttaattttt ttagcagtaa atatgctaaa
    25081 ctagtcacaa aatagactaa tcccatacgt tgaagtactc caagtattct tacagtatct
    25141 aaatcaggat ttcctaggta atttaagaaa aatccaaata atatcaataa gatacttctc
    25201 ttgaatatac taagtattat actcagtgtg gatttattat tttttagttt actatttatt
    25261 gatattggaa ttgtaacacc taaagatata acaaaaaaag gaaatgcaaa atctgcaagt
    25321 gttacaccat gccatacagc atgtcttaat tgaggataca ttctcatcca agtcccagga
    25381 ttattgcaga ctatcatgag ggctattgat agccctctta ttatatctat tgatttaatc
    25441 ctactattca taagtttaga atctacagca ttatttgaaa tt
//
LOCUS       DAEQCW010000052        24573 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.052, whole genome shotgun sequence.
ACCESSION   DAEQCW010000052 DAEQCW010000000
VERSION     DAEQCW010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24573)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24573)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24573
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.052"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            266..643
                     /locus_tag="KRO40_002108"
     CDS             266..643
                     /locus_tag="KRO40_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2092926.1"
                     /translation="MMIRKIPQAELKVMKFIWKVDVTVTSKDVIEAMEQKYGWKQTTT
                     LTLLSRLVKRGFLDAQKIDRYTHYTIRVKHKDYLSFETKDFLSNIHDDSLRSLISALH
                     DDENIGKDKLDFLESYFDNLKDE"
     gene            636..1784
                     /locus_tag="KRO40_002109"
     CDS             636..1784
                     /locus_tag="KRO40_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protease"
                     /protein_id="HBH2092927.1"
                     /translation="MNNYMLYVFENLIKTTIVCSLGICLLLFLKRYLFKKFSKRFNYY
                     IWLIIVFRMLLFLFNYTIVYEVKEPKENALGNNITQIDISTDNNLMLYVAYLWLFVTI
                     VIAVYTFIKYTRFKNLVVDVSYDIEDNDINCIYKNLLKELNIKKKIELRGSDELISPA
                     GMGLFKSYIFLPDYPYSKDELTWILKHELMHFKNKDILIKFLVLSVRIIYWFNPLVYV
                     MSNKVNLDCELCCDESVLVECSLKDKKEYALALIKSIKFSKNYNSKILTTEFDKTNLE
                     KRLESIVKKKGKSGILIAVLVFMTSITSFVEVDAQVRIDEGNNGMNNNINEFLLNKTT
                     DKIINIYYKDAPNEIRKFYEDKCELEGKIPRDYDIIEMDMKDYNQLIK"
     gene            1801..2403
                     /locus_tag="KRO40_002110"
     CDS             1801..2403
                     /locus_tag="KRO40_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein"
                     /protein_id="HBH2092928.1"
                     /translation="MLTKLRKIVAIMCCLLLTFTSVAFADTSKEKGGSKETVPEKNLD
                     SFTLSGYIYTYENAPQEIRDEHKQNCEEINIDPKPDDEIFVPESANLMNEDNSKGVYA
                     SYTVSYNIGAKTITIMSNEYLTISTTKVIRKGNSGKEVKAAQIMLTLLGYNVGIDSSF
                     GSKTYNAVVSFQKKYGLSADGIIGPATWDKLGRLTDPTLS"
     gene            complement(2496..3518)
                     /locus_tag="KRO40_002111"
     CDS             complement(2496..3518)
                     /locus_tag="KRO40_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBH2092929.1"
                     /translation="MDYNDLLKSARENFNGTCKVCKICNGLACAGDVPGMGGKGSGSS
                     FIENRKSLEKIKINMRVIHNVSKPDTSIELFGRKMSSPIFAAPVSGTILNMGGKVSEK
                     EYIEPVVRGCSNSGIYAMVGDTNVDTFLLDNLDVLKDNRGNGIVFIKPWNNSKIIDKI
                     RLSEEAGAFAVGVDLDACGLINNQFQENPFSPKTIDEIRELVESTRLPFIIKGIMTVD
                     DALMAVESGASAIIVSNHGGRVLDYTPGTCEVLPDIAKSVKGKITILVDGGVRTGVDV
                     VKMLGLGADAVLMGRPFVTASFGGGLDGVEFFIEKVRNELCETMILTGCQNVKDIDGR
                     VIWNLL"
     gene            complement(3847..4029)
                     /locus_tag="KRO40_002112"
     CDS             complement(3847..4029)
                     /locus_tag="KRO40_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092930.1"
                     /translation="MYKDKSDECIHLMTAYIDSISGYYSFIDTQLEDFMMKYGENIVD
                     SNLHSIMMLLCKWGLS"
     gene            4342..4761
                     /locus_tag="KRO40_002113"
     CDS             4342..4761
                     /locus_tag="KRO40_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3785 domain-containing protein"
                     /protein_id="HBH2092931.1"
                     /translation="MSLYKFIYDDKEYLLKEENCSALINDEENPVQGVSISKIIDILN
                     EAEEVDFDVEYYQEACPLCLEGVKEKKKFFPFLEYHFYIFSKDGEYVISNISVDYKGL
                     SFNKLSRANKVDNSYIVSVIICENCQDYIVQIENCIV"
     gene            4892..6733
                     /locus_tag="KRO40_002114"
     CDS             4892..6733
                     /locus_tag="KRO40_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2092932.1"
                     /translation="MEEIDDTILDSMFKLTLNERLLTNNDFIENKIDVVKNLIDCYKT
                     EQNSLMLLKSNFLLALLYGIQGFSEKMKEYILISCKYIDKCLPKDYKFLARFYSQIAI
                     LSLKNEDVNKANLYMDKFNLICDENNFLIEEIIFKSQLIYIKASKCIESSVIIKEIET
                     LYIKIKEINDFNCKKIYFFIIGKIYFLFLDDALIAKVNFLKARKYADLLKDMQVSSLC
                     NIKIGECECSFENYECSMEYFNEVISNKKYRNVNIIQKYRASNNITKILIKTRNYPVA
                     INNLAKSEVYLEKIKNHSLKEVEKFDLFISLAMYYAKSNEKSFEQSICYLDRAKNILN
                     MIKNIEEYIIYDLEIIYHQAKIYYIFGYYDNALNTNKKLLEKSKNAKNYNYVKLAYKS
                     IYLCFEKIQNYEMSMKYFKMYYELKMMYIKARNRNYIDSLNYRHEYIEKEINNMRKVK
                     LDLDKKKYVDHLTSAYNRTFLNDFLEKQEVSEYCTAFMIDVDYFKEYNDTYGHYNGDI
                     ALKNITIIIKKYLKKDMLMIRYGGEEFLILSVCKDYKKSKIFGRKLCRIVKKFLNNNL
                     TVSIGIDTCKNSSIDIKEIIENADKALYKAKESGRNRCLHYHDFKNF"
     gene            6760..8646
                     /locus_tag="KRO40_002115"
     CDS             6760..8646
                     /locus_tag="KRO40_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2092933.1"
                     /translation="MKRSLIEDLKRNINKIEYDMLTKFYLNLTDLNYILDYHKDLLNT
                     KLEDNSRVYTLYLISLINYIKKDREASYNYLIESLKYIKKLSLKDDSDIISKIYIYLT
                     LSAISIRKYDKVNNFYFSAKKIIRQNHLNELLVLLNMSLCVEISALYQTKTDVIALVE
                     EVSFFKTLKNKALVSRANYIFGRVYLYLFNNFIKSMEYLIECLKLAQENNLYSIEAFC
                     KCIISLCYLESGNNVEAIKYINNVLDVAHSNNSISVTERVSIKIDLIWAYLKEDMNKE
                     AEVILLKTIKLMKVVEGVYKDYLYSFIFLYSAEIELKKDNCSFEKVNTYLILSKNIYK
                     SFGDVFIYNSKLDYIYKLYGDLYIKFGNIDEGISCYIKGLNLVKKSSLNLRKISIFYG
                     LIANGYELKKDFKLAIEYYKSMDWYSDRWEKNNSYKTSQAIHKQYELRQKQESLRLLV
                     DDNKKLENDILKDGLTKLYNRRYLEQQLDLFNETRDKNMVAILVDIDCFKSYNDNYGH
                     LAGDKVIVKVTDIIRSVFIDITEHIIRYGGEEILILVDSIESIGVEEIDNIELYIKRV
                     FKLLEFEGIEHIYSKIKNYITISAGVSIKRCRSRKDVEILIEDADKNLYKSKKAGRNQ
                     YIII"
     gene            8654..10654
                     /locus_tag="KRO40_002116"
     CDS             8654..10654
                     /locus_tag="KRO40_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092934.1"
                     /translation="MILLRKKIGIIASDIELKERIEELYREDVENGTIIIDILNLDLM
                     ENQGRILVEKGAQAIIGRGGGYSLVIDTVNVPVIPMNMKSTDLLRAIEIAKKYSKKVV
                     LILGDNEVSFDYVGWRNVISTEITEEWFESKYEIRSKVVKYIDQKDEIVIVGGGLACS
                     FARQYGIDSVFATASDESIREAVEYCKKLLDTLGEEKFNNEVLRNILDGIKDGVIAID
                     SNGSIILYNESAKNMLKVERKCALNKYILDVFPKMEWMLDCLHEKEDVEDRKIRNINN
                     LIVNTRTTLIKVDNSTYGVLGIIQDITKLQNLERKIRFDLNQKGLYARYTFDDFLFKD
                     KLTKEFIEEAKKIGKSDYTTLLYGESGSGKEIIAHSIHNISKRKDRPFVAINCATIAE
                     NLLESELFGYEEGAFTGARKGGKRGLFELAHGGTLFLDEINSLSFNIQTKLLRVIEER
                     QIMRIGSDYIIPLDIRIIAATNESLTEKIVMGTFRADLFYRLSSLEINIPPLRDRRED
                     IIPLFNNFVNEVLKDDGLNGINSIDENFVLTKDEMDKLYNYSWPGNVRELKTIAQKYV
                     VTGKIKLRQDRDFKTKKLLPNSEVDKFNSETTASVEVQDESINISKINDGKISIDIKE
                     VNKYVEEKIISMLFAQGLSKNEVAQVLGISRTSLWKKYNKNI"
     gene            10916..12175
                     /locus_tag="KRO40_002117"
     CDS             10916..12175
                     /locus_tag="KRO40_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2092935.1"
                     /translation="MSQSMVGKHAMWPKENDVIFSISGRAQAAEKAFGMDNVINATIG
                     ALMDDSGKLITMKTVYEEYKALDNCEIGAYAALEGQPDYLEAVKKVFFRDYLPEGHIR
                     VLASPGGSGAIKLAVWNYTNEGDEVLTSDWFWSPYVSIAEEANRKVVNYQLFDENRRF
                     NFESFKEKFVNIAEKQGRVFTIINTPAHNPTGYSVADDEWDKILDLSKEVAKDKDKKI
                     IFFVDSAYIDFAGDDDVCRKFFKKFSNLPENVLVLVGFSMSKGFTAYGMRMGAIICIS
                     SSEDVAEEFHYSCVHSCRANWSNCNRSAMAVLSNIVNDPKKFKEYEDEKEIYKNMLTR
                     RADVFVKEAERVGLEILPYIAGFFVSIPCDNPKEVCEELTKHNLFAVPLKMGLRFAVC
                     AVSEDKCKKAPSIIKEALESLEVKINN"
     gene            12236..14023
                     /gene="iorA"
                     /locus_tag="KRO40_002118"
     CDS             12236..14023
                     /gene="iorA"
                     /locus_tag="KRO40_002118"
                     /EC_number="1.2.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate ferredoxin oxidoreductase subunit
                     alpha"
                     /protein_id="HBH2092936.1"
                     /translation="MKQLMTGNEAIARGAYEAGVKYASAYPGTPSTEILENIATYKDA
                     IVAEWAPNEKVALEAAIGGSIAGARTMASMKHVGLNVAADPIFTYAYTGVNGGMVLIT
                     ADEPGMHSSQNEQDNRMYAKFAKIPLFEPSTSQEAKDMIKEAFEVSEKYDTPVLYRVT
                     TRLCHSKGLVECYDREEVEIKEYVKNAKKMVTVPANAQIRRGVVEERMEILKKFSNET
                     DLNYYEINDTKIGVIASGMCCNFAKEVFGKNASYMKLGFTNPLPYEKIKEFAEKVDKI
                     YVIEENDPFIEEQIKAYGIDCIGKDVIPPYGEMTPDVLRKAIFGKTNDTIEYKSELVT
                     PRPPSFCAGCPHRGFFYELGKRKNLIVGGDIGCYTLGFAPPYNGIDYVVCMGSAFGTA
                     HGAQKVLNMKDDNEKRLVGVLGDSTFFHTGINGLLDVVYNRGNSISVILDNRITGMTG
                     HQENPGSGYTLQGAKTKEVDIEGLVKACGIEHVRVINPNNLKEVNEALDWALAIEDEP
                     SVIITRWPCVLKKFSKEDIEEFNNPFKTKCKVDHDKCIGCKLCLKTGCPALSFDKENK
                     LSNIDRNQCVGCGVCAQVCPKQAIVKEEK"
     gene            14025..14600
                     /locus_tag="KRO40_002119"
     CDS             14025..14600
                     /locus_tag="KRO40_002119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate oxidoreductase subunit beta"
                     /protein_id="HBH2092937.1"
                     /translation="MTKSILLVGVGGQGTILASKLLTMGLMEAGYDVKMSEIHGMSQR
                     GGSVSSQVRYGDCVHSPVIEIGGADILVSFEKMEALRWFNYLKPEGKALVNNHRIDSM
                     TVLIGGAEYQESDIDAELSRLNAKVINAADKAEELGNSKIMNVILLGCLVKSMQLESI
                     DWEKIISENVKPKFVELNIKAFHEGMEMVSK"
     gene            14653..15723
                     /gene="buk"
                     /locus_tag="KRO40_002120"
     CDS             14653..15723
                     /gene="buk"
                     /locus_tag="KRO40_002120"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH2092938.1"
                     /translation="MTYRILAINPGSTSTKIAVYDGEEQILVKTIDHPAEEIAKYNTI
                     QDQFEMRKEAVLNILKENSIDLKSLSAIVGRGGVLPPVKSGAYLVNEEMIDVLRHRPV
                     LEHASNLGAVVAHAISEPLGINSYIYDSVAVDELIDVARISGLCGMDRSSAGHALNTR
                     AMALKYAKDKGKDYKSLNLIVAHIGGGVSIYLHEKGRMVDMLSDDEGPFSPERSGRVP
                     ATKLVAACYSGQYSEREMTKKIRGKGGIVSYLNTVDAREVEKMIAEGNEEAKIIYEAM
                     AYQLAKGIGELATVVDGKVDAIIITGGIAYSEMFTSMVKKKVEFIAPVEIMAGENELE
                     SLAFGTLRVLNGEEEARIYSEN"
     gene            15941..16642
                     /locus_tag="KRO40_002121"
     CDS             15941..16642
                     /locus_tag="KRO40_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092939.1"
                     /translation="MGKISLKSMIRLFSGFFIFAISSVLMINAHVGLMPWDVLHQGLS
                     IKLGITIGQASIMVGVVIVILDAVFGENIGWGTLLNMTFIGIFIDLVIFSGVIPHASN
                     TYIGVFMVVIGIILAAIASFLYLGVCLGSGPRDGLMIALQKKTNKSVRLVRTILEILA
                     LVVGWLLGGSVGIGTLVSALGLGYVLQIVFRIFKFDTKLLKHRFIIDDIREWKEKKSN
                     EHKCKSSIVIKNEQN"
     gene            16702..17208
                     /locus_tag="KRO40_002122"
     CDS             16702..17208
                     /locus_tag="KRO40_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HBH2092940.1"
                     /translation="MELWDLYNADGIKTGNVIKRGNSIEEGYYHLAVEVWILNSNSQI
                     LIQKRSKSKKTLPNMWGMTTGCIVSGEDSLEGAIREAKEEIGIDITKDEMKVFRSMIH
                     EDTLWDVYLVKKEYDISKAILQEEEVSDIKWVSTDEIRQLLKEGLFFEYPEIYELLYE
                     IDNNKLNI"
     gene            17383..18405
                     /locus_tag="KRO40_002123"
     CDS             17383..18405
                     /locus_tag="KRO40_002123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH2092941.1"
                     /translation="MEDNKGLARDSSKYKIVSISVVVIILITFWYMLNMVLLTFIMTF
                     IFYNLLVATRKRIKKFSSLNIPDSLIIIVLYALFAILLVLISYAVVPIIIVQLTELSR
                     VFSDFDVNQFAQSLGPKLYPIVSKLDFNKYISQAGLLIASTATKVGSFGVNILLAFLL
                     SLLLLLEKNEIKNFGDKLSDSKISFIYNSLVFFGKSFVKNFGEVMKVQVMIAFINSVV
                     SMIFLGFMGFPQIWALGFMIFVLGLIPVAGVIVSLIPLTVIAFNTGGITKVFGVLLMI
                     CIVHAVETYILNPKLMSNRTKLPVCFVFIILLVGEHYLGVWGLLIGVPIFMFLMDILG
                     VKFTSR"
     gene            complement(18552..18860)
                     /locus_tag="KRO40_002124"
     CDS             complement(18552..18860)
                     /locus_tag="KRO40_002124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBH2092942.1"
                     /translation="MKNNNLNCAATNCAYNTSGYCYAGSIKVDGMQATTTENTYCASF
                     EDKYTSGITSRSNETNQVDTDNIHCEAVKCKYNKNELCKAEKVHINERNASCETFEMK
                     "
     gene            complement(18920..19348)
                     /locus_tag="KRO40_002125"
     CDS             complement(18920..19348)
                     /locus_tag="KRO40_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092943.1"
                     /translation="MNNKLHELEKNLPEISCSFCTHLSFKGPSLDYRYDIRCVISDTK
                     PDFRGCCEYFEPEYTELNTGDLDNLYINFLETCLKVNYNDYINSMYWKLFKERTLLEN
                     NFKCSICGSTENVDVYHVNKNLGRETSKDVVVKCDKCNCK"
     gene            complement(19571..21028)
                     /locus_tag="KRO40_002126"
     CDS             complement(19571..21028)
                     /locus_tag="KRO40_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBH2092944.1"
                     /translation="MTTFLIGLAILLIGGALYGAYCEKVFGPDDRKTPALAQSDGVDY
                     VPMKKWKNSLIELLNIAGTGPILGPIQGILFGPIAFILIPIGCVFGGALHDYMSGMIS
                     IREKGAQMPSLISRFLGNKVFQVYNIFLCLLMLLVGAVFIYTPGDLVVTQILNMKSTI
                     NNPVVWIVYGLIFLYYLCATLFPIDKIIGKVYPIFGAILLLSAAGVGIGIFTQGYDLA
                     NLSLANWKGIHPDGIPLIPTFFVTVACGIVSGFHSTQATLIARSVSNEKEGKTTFYNM
                     MILEGLIAMIWAAAAMGIYNKGIPKELVGSPDVIGLVARDLLGSIGGIIAIIGVIVLP
                     ITSGDTALRSLRLMLADYFHYDQKEKKHRVILSICIFIPVIAILIFAKLSASGFNILW
                     RYFSWSNQTIAIFAFAMITVYLIIKEKNYIISLIPGMFYSFVIFSYIFNAQIGFNLNI
                     NISYVLAAIFTVLYAILTVRSGRKLKSKADTKLAD"
     gene            21446..22360
                     /gene="nadA"
                     /locus_tag="KRO40_002127"
     CDS             21446..22360
                     /gene="nadA"
                     /locus_tag="KRO40_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolinate synthase NadA"
                     /protein_id="HBH2092945.1"
                     /translation="MDKDLTYQIKELKKEKNAIILAHFYQPPEIQELADAVGDSYYLS
                     EIARDCKEEVVVFCGVRFMGESAKILSPEKTVLMPVSNAGCAMADMVDEEGVIKLKQQ
                     YPNALVVCYINSTAKVKAHCDVSVTSSSAIKILENIDNKEIIFLPDKNLGGYIAEQFP
                     DKNFIFWDGYCKYHNNIRAEEIIELKDKYKNAEVLVHPECKKEIRDLGDYVGSTSGII
                     KYATNSKNKDFIIATEEGILHELKKNNPNKNFYIPGGKILCTDMKKTTLENLYSTLKN
                     MENEVIVEDEIMEKALNSLLNMHKLAEG"
     gene            22373..23674
                     /locus_tag="KRO40_002128"
     CDS             22373..23674
                     /locus_tag="KRO40_002128"
                     /EC_number="1.4.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-aspartate oxidase"
                     /protein_id="HBH2092946.1"
                     /translation="MNLEQDVLIVGSGVSGLYCALNLDKSLNVLVVSKSTIENNNTYL
                     AQGGISTARNIDDIESFVEDTMKAGQYKNRVEAVQVLADESIENVGQIVEYGMPLDKE
                     NGEIDYTREGAHSVNRIVHSKDNTGEVVFKTLLKEAKTRENITLIEDAYLLDILKDGN
                     KCIGARIFKSKKEIHVFSKIVVLATGGIGGLFKNSTNQRHLTGDGIAIALRNNIKIEN
                     LEYIQIHPTAFYEENNEGRRMLISESLRGEGAKLLNKNKERFVDELLPRDVVSKAIFE
                     QMEKDKLPYVYLDATHLDSEYLINRFSFIYNECLARGTDITKECIKVSPAQHYFMGGI
                     HVDLDSKTSMENLYAVGEISCTGVHGANRLASNSLLEGLVFSKRAAKNINSVIDNVKV
                     KFIDVPDMDIDIEQVKKENKILVIKEIERTSEDFGDELFDY"
     gene            23655..24491
                     /gene="nadC"
                     /locus_tag="KRO40_002129"
     CDS             23655..24491
                     /gene="nadC"
                     /locus_tag="KRO40_002129"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HBH2092947.1"
                     /translation="MNYLIIDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQD
                     GIIAGLGVFKRVFEILGDVDVKLYKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYL
                     QRMSGIATITSRYVEKLEGTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGI
                     LLKDNHIGAAGSVKKAVELARKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSL
                     EMAKQAVDIINGRAIVEFSGNVNLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNLR
                     NI"
BASE COUNT         9702 a         2611 c         4192 g         8068 t
ORIGIN      
        1 aagtattata atattccttg tgtgaaaata taggaatttt tattaaatag ttttaatgtg
       61 taaataacat tctacactat tgtaattaaa tatgtaaaaa gtaaaatatt taaatagata
      121 tattttaaaa tctaactttt aatattgtaa aaaaattaga aatttaacaa aaagtacaaa
      181 aattcacatt tttttcataa agtgtttgac taaaaaattc acatgttgta gaattaaggt
      241 agcaggagtt ttgagggagg tgtaaataat gataagaaaa ataccacaag cagaactaaa
      301 agtaatgaaa ttcatttgga aagtagatgt tacagtgaca tcaaaagatg ttattgaagc
      361 tatggaacaa aaatatggct ggaaacaaac caccacactg acacttttat ctaggctggt
      421 aaaaagagga ttcttagatg ctcaaaaaat agacagatat acacattaca caataagagt
      481 aaaacacaaa gattatttaa gttttgagac aaaggatttc ctaagtaata tacatgatga
      541 ctctttaaga agcttaattt cagcattaca tgatgatgaa aatataggta aagataagct
      601 agattttcta gaaagttatt ttgataattt aaaggatgaa taattatatg ctatatgttt
      661 ttgaaaatct tataaagaca actattgtat gtagtcttgg tatttgtcta ttattatttt
      721 tgaaaagata tttatttaag aagtttagta agagattcaa ttattatatt tggttgataa
      781 tagtctttag aatgttactt tttctattta attatacaat agtgtatgaa gtaaaagaac
      841 ccaaagaaaa tgcattagga aataatatta cacaaattga tatttctaca gataataatc
      901 ttatgctgta tgtagcttat ttatggttat ttgtaactat agtcattgca gtttatacat
      961 ttataaagta tacaagattt aaaaatctag ttgttgatgt atcttatgat attgaagata
     1021 atgatataaa ctgtatctac aaaaacttgt taaaagaatt aaatataaaa aagaaaattg
     1081 aattaagagg ttctgatgaa ttgataagtc cagcaggtat gggattattt aaatcttaca
     1141 tattcttacc agactatcct tatagtaaag atgaactaac ttggattttg aaacatgaat
     1201 taatgcattt taaaaataaa gatattttaa taaagttttt agttttgtct gttagaataa
     1261 tatattggtt taatccactt gtatatgtaa tgagcaataa agtaaatcta gattgtgaat
     1321 tatgttgtga tgaaagtgtt ttggtagaat gttctttaaa agataaaaaa gaatatgcac
     1381 tagcacttat aaagtcaatt aagtttagta aaaattataa tagtaagatt ttgacaaccg
     1441 agtttgataa gacaaatttg gaaaagagac ttgagagtat tgttaaaaag aaaggcaaaa
     1501 gtggaatact aattgctgtt ttagtattta tgacttctat aacatctttt gttgaagttg
     1561 atgctcaagt tagaattgat gagggtaata atggaatgaa taacaatatt aatgaatttt
     1621 tattgaataa gacgactgat aaaattataa atatttatta taaagatgca ccaaatgaaa
     1681 ttaggaaatt ttatgaagat aaatgcgaat tagaaggtaa aatacctaga gactatgaca
     1741 taatagaaat ggatatgaaa gattataatc aattaataaa ataattataa ggaggatttt
     1801 atgttaacaa aattaagaaa aatagtagct attatgtgtt gcttattgct tacttttaca
     1861 agtgtggcat ttgctgacac aagtaaagag aaaggaggaa gtaaagagac tgttccagag
     1921 aaaaacctag attcttttac tctttctggg tatatatata catatgaaaa tgcgccacaa
     1981 gaaataagag atgaacataa acaaaattgt gaagagataa atatagaccc taagccagat
     2041 gatgagatat ttgttccaga atcagctaat ctaatgaatg aggacaatag taaaggtgtt
     2101 tatgcaagtt atactgtttc ttataatata ggtgctaaaa ctataacaat tatgagtaat
     2161 gagtatttga ctataagtac aacaaaagtt atacgaaagg gtaatagcgg aaaagaagta
     2221 aaagctgcac aaatcatgtt aactttactt ggttataatg taggtataga tagttctttt
     2281 ggaagtaaga catataatgc agttgtaagt ttccaaaaaa aatacggttt gtctgcagat
     2341 ggaataattg gtccagctac ttgggataaa ttgggtagac taactgaccc tactctttca
     2401 taggattaaa atctaaaaat atattaaata gtgtctcaat atgatttttc aatttaaatg
     2461 agacactatt taaatataaa tgttataaaa ctattttaca ataaattcca tataactcta
     2521 ccatctatat ccttaacatt ttgacaacca gtcaaaatca tagtctcaca taactcattc
     2581 ctaaccttct ctataaaaaa ctccacacca tcaagaccac cgccaaaaga agcagtaaca
     2641 aaaggtcttc ccatcaaaac agcatcagca cccaatccaa gcatcttaac tacatcaaca
     2701 ccagtcctaa ctccaccatc aacaagtatt gttatctttc cctttacaga cttagctata
     2761 tctggaagta cctcacaagt accaggagta taatcaagta ctcttccacc atgatttgaa
     2821 acaataatgg cactagcacc agactctaca gccatcaaag catcatctac agtcataatt
     2881 ccttttataa taaaaggtaa tctagtggat tcaaccaatt ctctaatctc atcaattgtt
     2941 ttaggagaaa aaggattttc ttgaaattga ttattaataa gtccacaagc atcaaggtct
     3001 acaccaactg caaaagcacc tgcttcttca gacaatctaa ttttatctat tatctttgaa
     3061 ttattccaag gctttataaa tacaattcca tttcccctat tatccttcaa tacatctaaa
     3121 ttatccagta aaaaagtatc tacattagta tcgccaacca tagcataaat tccagaatta
     3181 gaacaacctc taacaacagg ctctatgtat tctttttcgg aaactttacc acccatgttc
     3241 aatatagtac ctgatacagg tgcagcgaat ataggagaac tcatttttct accaaataat
     3301 tctatggatg tatctggctt tgaaacatta tgtatgactc tcatatttat ctttattttt
     3361 tctagacttt ttctattttc aatgaaagac gaaccacttc ctttaccacc cataccagga
     3421 acatctccag cacaagctaa tccattacaa attttacata ctttacatgt tccattaaag
     3481 ttctctctag ctgattttag taagtcattg taatccatac aaaatctctc ctttttataa
     3541 tattaaaatt gagtattact atattgaaaa tatcttaatt gtaaatatag ggatgttatt
     3601 atgatgagct aaactagata atacatatta gatatttttt attgttgtag atagttaaat
     3661 tatatcatat tagatagtca aattttgaaa aaaactaact tatttaagta tacattttga
     3721 aaaaattaaa aaagctatat atagattttt aaagaaatct atatatagct tttaagttta
     3781 tgtcaatctt ttttgttaat gaataaataa tatagaatac aatatacaaa aaagtttctt
     3841 gaaatgctaa gataatcccc atttacaaag caacatcatt atactgtgta aatttgaatc
     3901 aacaatgttt tcaccatatt tcatcataaa atcctctaat tgtgtgtcaa taaatgaata
     3961 atatccactt atactatcga tgtatgcagt cattaagtgt atacattcat cacttttatc
     4021 tttatacata tatatctccc cctatataca atatataaat ttagatacca aatcgtatca
     4081 tattaaatag ttaagtgtgt aacatctatg cagttatata tttatatcat tatattaata
     4141 actaaagtga gttttgacaa tagattttgg gaaactggat gttcaaagtg caaacttgga
     4201 ttttaaaatc attaattaag atagcgcata ggaatatatg tatacataac ttaattataa
     4261 agattataaa caattacttt tattaacttt atttaaatgg tagaataact tggagattaa
     4321 taattataag gaggatataa tatgagttta tataagttta tatatgatga taaggaatat
     4381 ttattaaaag aggagaactg tagtgcttta ataaatgatg aagaaaatcc agttcaagga
     4441 gtaagtattt caaaaataat tgatatactt aatgaagcag aagaagttga ttttgatgta
     4501 gaatattatc aagaagcatg tccattatgt ttagaaggag taaaagaaaa gaaaaaattc
     4561 tttccttttt tagaatatca cttttatatt ttcagtaaag atggagaata tgtaataagc
     4621 aatatatctg ttgattataa aggactatct tttaataaac tatcaagggc aaataaagtt
     4681 gataatagtt atattgtaag tgtgataatt tgcgaaaatt gtcaggatta tatagttcag
     4741 atagaaaatt gtatagttta gtgtaaagta tgtcttaatt taagagaaat ttctaaattg
     4801 agacatcaac ttttttcaaa aatagtatgg aaaattacta aatttatgag ataatgtaag
     4861 tcggaggtga gttacaatat atagtaaata tttggaagag atagatgata caattttaga
     4921 ttcaatgttt aaactaacct tgaatgaaag attattgact aataacgatt ttattgaaaa
     4981 taaaattgat gtagtaaaga atttaattga ttgctataaa actgaacaaa atagtttaat
     5041 gttattaaaa tcaaattttt tgctagcttt attatatggt attcaagggt ttagtgaaaa
     5101 aatgaaagag tatattttga tttcctgtaa atatattgat aaatgcttac ccaaagatta
     5161 taaattttta gcacgatttt attcacaaat agctatttta agtttaaaaa atgaagatgt
     5221 aaataaggca aatttatata tggataaatt taatcttatt tgtgatgaaa ataattttct
     5281 aattgaagaa attattttta aatcacaact tatttacatt aaggcaagta agtgtataga
     5341 atcttctgta ataattaaag agatagaaac gttgtatata aagataaaag aaattaacga
     5401 ttttaattgt aaaaaaatat atttttttat tattggtaaa atatattttt tgtttttgga
     5461 tgatgctcta attgctaagg taaatttttt aaaagcaaga aaatatgcag atttactaaa
     5521 ggatatgcaa gtatcttcac tatgtaatat aaagataggt gagtgtgaat gttcgtttga
     5581 aaattatgaa tgttccatgg aatatttcaa tgaagtaata agcaataaaa agtatagaaa
     5641 tgtaaatata attcaaaaat atagagcatc aaacaacata actaaaatat taataaagac
     5701 tagaaattat cctgtcgcaa taaataattt agcaaaatct gaagtatatc tagaaaaaat
     5761 taaaaatcat agcttaaaag aagtagagaa gtttgattta tttataagtt tagccatgta
     5821 ttatgcaaaa agtaatgaaa aatcttttga acaatcaata tgctatttag atagagctaa
     5881 aaacatatta aatatgataa aaaatataga agaatatata atatatgatt tagaaataat
     5941 ttatcaccag gcaaagatat attatatctt tggatattat gataatgcct taaacacaaa
     6001 taaaaaactc cttgaaaaat ctaaaaatgc taaaaattat aattatgtga agttagcata
     6061 caagagtata tatttgtgtt ttgaaaagat tcaaaattat gaaatgagta tgaaatactt
     6121 taaaatgtat tatgagttaa aaatgatgta tataaaagct cgaaatagaa attatataga
     6181 ttccttaaat tatagacatg agtatataga aaaagaaata aataacatga gaaaagtaaa
     6241 acttgattta gataaaaaaa agtatgttga ccatttgaca agtgcatata atagaacttt
     6301 tttgaacgat tttttagaaa aacaagaagt tagtgaatat tgcacagcat ttatgataga
     6361 tgtagattac tttaaagaat acaatgatac ttatggacac tataatggag atattgctct
     6421 taaaaatata actataataa taaaaaaata tctaaaaaaa gacatgctta tgataaggta
     6481 tggtggagaa gaatttctga tattatctgt atgtaaagat tataaaaaaa gtaaaatatt
     6541 tggaagaaaa ttatgtagga ttgtaaagaa atttttaaac aataatttga cagttagtat
     6601 tggcattgat acatgtaaaa atagtagtat agatataaaa gaaataattg aaaatgctga
     6661 taaagcttta tataaagcaa aggaaagtgg tagaaataga tgtttgcatt atcatgattt
     6721 taagaatttt taactgttga aataggattg gtgatttact tgaaaaggag tttaatagaa
     6781 gatttaaaga gaaatataaa caagatagaa tacgatatgt tgactaaatt ctatctaaat
     6841 ttgacagatt taaactacat cttggattat cacaaagacc ttttaaatac aaaattagaa
     6901 gataatagta gagtctatac tttatattta attagtctta taaactatat aaaaaaagat
     6961 agagaagcat catacaacta tttgatagag tcattaaagt atattaaaaa attgtcatta
     7021 aaagatgatt cagatataat atctaaaatt tatatttatc ttactttatc agctatttct
     7081 ataagaaaat atgataaggt aaataatttt tatttctcag caaaaaaaat tataagacaa
     7141 aatcatttaa atgagttgtt ggtattgtta aatatgagtt tatgtgtaga aataagtgct
     7201 ttatatcaga ccaaaacgga tgtaatagct ttagtagaag aagtgtcttt ttttaaaact
     7261 ttaaaaaata aagctcttgt aagtagggca aattatatat ttgggagagt ttatctatat
     7321 ttatttaata actttataaa aagtatggaa tacttaattg aatgtctaaa attggctcaa
     7381 gaaaataatt tatactctat agaggctttt tgtaaatgta taataagttt gtgttattta
     7441 gagagtggaa ataatgtaga agctataaaa tacataaata atgtattaga tgttgcacac
     7501 agtaataact caatatcagt aactgaaaga gtgtctataa aaatagacct tatatgggca
     7561 tatttaaaag aagatatgaa taaagaagca gaagttattt tattaaagac tataaaatta
     7621 atgaaagttg ttgaaggtgt atataaggat tatttatatt catttatatt tttatattca
     7681 gctgaaattg agttaaagaa agataattgt agttttgaaa aggtaaacac ctatttaatt
     7741 ttatcaaaaa atatatataa aagttttgga gatgttttta tatataattc taaactagat
     7801 tacatatata agttgtatgg agatttatat ataaaatttg gtaatataga tgaaggtata
     7861 agttgttata taaaaggttt aaatttagtt aaaaagagtt cattgaatct tagaaaaata
     7921 tctatatttt atgggctaat agcaaatgga tatgagctaa aaaaagattt taaactggca
     7981 atagaatatt ataaaagtat ggattggtat tctgataggt gggaaaaaaa taattcctat
     8041 aaaacatctc aagcaattca caaacaatat gaactcagac aaaaacaaga gagtttaaga
     8101 ttactagtgg atgataataa gaaattagaa aatgatattt taaaagatgg acttactaaa
     8161 ctatataata gaagatatct ggaacagcag ttggatttat ttaatgaaac cagagacaaa
     8221 aatatggtcg caatactggt cgatatagat tgttttaaaa gttataatga taattatggt
     8281 catctagcag gagataaagt tatagttaag gtaactgata ttataagaag tgtatttata
     8341 gatattaccg aacacataat cagatatggg ggagaagaaa ttttaatatt agtagattct
     8401 atagaatcaa tcggtgttga agagattgat aatatagaat tatatattaa aagagttttc
     8461 aaacttcttg aatttgaggg tattgaacat atatattcta aaataaaaaa ctatataact
     8521 ataagtgctg gagtaagtat aaaaagatgt cgtagtagaa aagatgttga aatattaatt
     8581 gaagatgcag ataagaacct atataaatca aaaaaagcag gtagaaatca atacattata
     8641 atttaaaatt gaggtgattt tgttgcgaaa aaaaatagga attatagcct ctgatattga
     8701 attaaaagaa agaatagaag aattatatag agaagatgta gaaaatggaa ctataataat
     8761 cgacatactt aacctagact taatggaaaa tcaaggtcgt atacttgttg aaaaaggtgc
     8821 ccaagctata attggtagag gtggaggtta tagtttagta atagatacag taaatgtacc
     8881 tgttatacca atgaatatga agtcaactga ccttttaaga gcaatagaaa tagcaaagaa
     8941 atattctaaa aaagtagtat tgattcttgg agacaatgaa gtttcttttg actatgttgg
     9001 ctggagaaat gtcataagta ctgaaataac tgaagaatgg tttgaatcta agtatgagat
     9061 aagaagtaaa gttgtaaaat atatagacca aaaagatgaa attgtaatcg taggaggagg
     9121 tttggcatgt tcttttgcaa ggcaatatgg aattgatagt gtatttgcaa ctgctagtga
     9181 tgaatctata agagaagctg tagaatattg taaaaaatta ttagatacat taggtgaaga
     9241 aaagtttaat aatgaagtgt tacgaaatat acttgatggt ataaaagatg gagtaattgc
     9301 tatagatagt aatggcagta taattttgta caatgaaagt gcaaaaaaca tgcttaaagt
     9361 agagagaaaa tgtgcactta ataaatacat cttagatgta tttcctaaaa tggagtggat
     9421 gttagattgt ttacatgaaa aagaggacgt agaagataga aagataagaa atataaataa
     9481 tctaattgtt aatactagga caacattgat aaaagttgat aatagtactt atggagtttt
     9541 aggaataata caagatataa ccaagctaca aaacttagaa agaaaaataa gatttgactt
     9601 gaatcaaaaa ggtctctatg ctagatatac ttttgatgat tttttattta aagataaatt
     9661 aactaaagaa tttattgaag aagctaaaaa aattggaaaa agtgattata caactttact
     9721 ttatggggaa agtgggtctg gtaaagaaat tatagctcat agtatacaca atataagtaa
     9781 aagaaaagat aggccttttg ttgctataaa ttgtgctact atagcagaaa atttacttga
     9841 aagtgaactt tttggctatg aagaaggtgc atttactggt gctagaaagg gtggaaaaag
     9901 agggctattt gaacttgctc atggagggac tcttttttta gatgaaataa atagtctatc
     9961 ctttaatatt cagacaaaac tattaagagt aatagaggaa cgtcaaataa tgagaattgg
    10021 ttctgattat ataatacctc tggatataag gattatagca gcaacgaacg aatctttaac
    10081 cgaaaaaata gttatgggta catttagagc agacttattt tatagattga gtagtttaga
    10141 gataaatata cctcctttaa gagacagaag agaagatata atacctttgt ttaacaattt
    10201 tgtaaatgaa gtattaaagg atgatggtct caatggaata aacagtatag atgaaaattt
    10261 tgttttgact aaagatgaaa tggataagct atataattat agctggcctg gaaatgtaag
    10321 agagttaaag acaatagctc aaaaatatgt tgtgacaggt aaaattaaat tgagacaaga
    10381 tagagatttt aaaactaaaa aattacttcc taactctgaa gtagacaaat ttaattctga
    10441 aacgacagca agtgtagaag tccaagatga atctataaat ataagtaaga taaatgatgg
    10501 taagataagt atagatataa aagaagtaaa taagtatgtt gaagaaaaaa taataagtat
    10561 gctttttgct caaggacttt ctaaaaatga agttgcacaa gttcttggaa taagcaggac
    10621 atctttatgg aagaaataca ataaaaatat ttaaatataa ttacatataa attattttga
    10681 agtaatgtta attttttaaa acaagtgtta agaaaaatta acattacttt tttgcaaatt
    10741 tttatttttt tagacaggca tatatattta taagaaaaat agttaaaaca cttaatttaa
    10801 taatgaaaaa aataataatt ctaaacaaaa tcaattttac ataaagtggg atttattggc
    10861 atagtaattg cttaatatat aatgtaagag taaatacaat tttaggggtg atggtatgag
    10921 tcaaagtatg gttggtaagc atgcaatgtg gccaaaagaa aatgatgtta tatttagcat
    10981 atctggcaga gctcaagcag cagagaaggc ttttggtatg gataatgtaa taaatgcaac
    11041 aataggcgct ctaatggatg attcaggaaa attgataaca atgaaaactg tatatgaaga
    11101 atataaagca ttagataact gtgagatagg tgcatatgca gctcttgaag gtcaaccaga
    11161 ttacttagaa gcagttaaaa aagtattttt cagagattac ttaccagaag gacatataag
    11221 agtattagct tcaccaggag gaagtggtgc aataaaatta gctgtatgga actatactaa
    11281 tgaaggagat gaggtattaa catctgattg gttctggagt ccatatgtaa gtatagctga
    11341 agaggctaat agaaaagtag ttaattacca actttttgat gaaaatagaa ggtttaattt
    11401 tgagtcgttt aaagaaaaat ttgtaaatat agcagaaaaa caaggtagag tctttacaat
    11461 tataaacaca ccagcgcata atccaactgg atatagtgtt gcagatgatg agtgggataa
    11521 aatattagac ttatcaaaag aagtcgcaaa agataaagac aaaaagataa tatttttcgt
    11581 agattcagca tatattgact ttgcaggtga tgatgatgta tgtagaaagt tttttaagaa
    11641 attttctaat ttgcctgaaa acgttctcgt attggttgga ttcagtatgt caaaaggatt
    11701 tacagcttat ggtatgagaa tgggggctat aatttgtata tcttcaagtg aagatgtagc
    11761 tgaagagttc cattactcat gtgttcattc atgtagagca aattggtcaa attgtaatag
    11821 aagtgccatg gcagtattat ctaacattgt aaatgaccct aaaaaattca aagaatatga
    11881 ggatgaaaaa gaaatataca aaaacatgct tactagaaga gcagatgtat ttgtaaaaga
    11941 agctgaaaga gtaggattag aaattcttcc atatatagca ggtttctttg taagtatacc
    12001 atgtgataat ccaaaagaag tatgtgaaga attgactaaa cataatttat ttgcagttcc
    12061 attaaaaatg ggtttaagat ttgcagtttg tgcagtttct gaagataaat gtaagaaagc
    12121 accaagtatt ataaaagaag cacttgaaag tttagaagta aaaataaata attaatttca
    12181 ttgaacaaat tgggtggact atgaatttaa taattgtaga tggagggaat tttatatgaa
    12241 acaattgatg acaggtaatg aagcaattgc acgtggagcc tatgaggctg gtgttaaata
    12301 tgcatctgca tatccaggga ctccaagtac agaaatatta gaaaatatag caacatataa
    12361 agatgcaata gttgcagagt gggctccaaa cgaaaaggta gcacttgagg ctgctatagg
    12421 gggttcaatt gcaggagcaa gaacaatggc ttctatgaaa catgttggtt tgaatgttgc
    12481 agctgatcca atatttactt atgcatatac aggggtaaat ggtggtatgg tacttattac
    12541 agcagatgag ccgggaatgc attcatctca aaatgagcaa gacaatagga tgtatgcaaa
    12601 atttgcaaag atacctttat ttgagccatc aactagtcaa gaagctaaag atatgataaa
    12661 agaagctttt gaagttagtg aaaaatacga tacaccagtt ttatatagag ttacaacaag
    12721 actttgtcat tcaaaaggat tagtggagtg ctatgataga gaagaagttg aaattaaaga
    12781 gtatgttaaa aatgctaaga aaatggtaac tgttccagca aatgctcaaa taagaagggg
    12841 cgttgttgaa gaaagaatgg aaattcttaa aaaattctca aatgaaactg atttaaacta
    12901 ctatgaaata aatgatacaa aaataggtgt tatagcctct ggtatgtgct gtaattttgc
    12961 caaagaagtt tttggaaaaa atgcatcata tatgaaacta ggatttacaa atccattacc
    13021 ttatgaaaaa ataaaagaat ttgcagaaaa agttgataaa atatatgtta tagaagaaaa
    13081 tgacccattt atagaagaac aaataaaagc atatggaata gattgtattg gaaaagatgt
    13141 aataccacca tatggagaaa tgacaccaga tgttttaaga aaagctatat ttggaaaaac
    13201 aaatgatact atagaataca aatctgaatt agtaacacca agaccaccaa gtttctgtgc
    13261 aggatgtcca catagaggat tcttctatga acttggaaag agaaaaaatt taatagttgg
    13321 tggagatata ggttgttata ctcttggatt tgctcctcca tataatggaa tagattatgt
    13381 tgtttgtatg ggttctgctt ttggaactgc acatggagct caaaaagttc ttaatatgaa
    13441 ggatgataat gaaaaaagat tggtaggtgt acttggagac tcaacattct tccatacagg
    13501 aataaatgga cttttagatg ttgtttacaa tagaggtaat tctatttcgg ttatattaga
    13561 taatagaata actggaatga caggtcacca agaaaaccca ggttcaggat atactttaca
    13621 aggtgctaaa actaaagaag ttgatataga aggattagtt aaagcttgtg gaatagaaca
    13681 tgtaagagtt ataaacccta ataatttaaa agaagtaaat gaagcactag attgggcttt
    13741 agctatagaa gatgaaccat cagtaataat aacaagatgg ccatgtgtac ttaaaaaatt
    13801 ctctaaagaa gatatagaag aatttaataa tccatttaag actaagtgta aagttgacca
    13861 tgataaatgt ataggatgta aattatgttt gaaaactgga tgtccagctc tatcatttga
    13921 taaagagaat aagttatcaa atatagatag aaatcagtgt gtaggatgtg gagtatgtgc
    13981 acaagtttgt ccaaaacaag caatagttaa ggaggaaaaa taatatgact aagagtatac
    14041 ttttggtagg tgtaggaggt caaggaacta tacttgctag taaattatta actatgggat
    14101 tgatggaagc tggatatgat gtaaagatga gtgaaataca tggaatgagt caaagaggag
    14161 gttcagtttc ctcacaagtt agatatggag attgtgttca ttctccagtt atagaaattg
    14221 gtggagcaga tatattagta tcttttgaaa aaatggaagc tttaagatgg ttcaattatt
    14281 taaaaccaga aggaaaagct ttagtaaata atcataggat agattctatg actgttttaa
    14341 tcggaggagc tgaatatcaa gaaagtgata tagatgcaga gttaagtaga ttaaatgcaa
    14401 aagttataaa tgcagctgat aaagctgaag aactaggaaa ttcaaaaata atgaatgtta
    14461 ttttattagg atgtctagtt aaatctatgc aattagagtc tattgattgg gaaaaaatta
    14521 taagtgaaaa tgttaaacca aaatttgttg aattaaacat aaaagctttc catgaaggta
    14581 tggaaatggt tagcaaatag tttataatag atataaatag actatagaaa ttaaggtgaa
    14641 aggaagaaaa ttatgactta cagaatatta gccataaatc caggttctac ttctacaaaa
    14701 atagcagtat atgatggaga agaacaaatt cttgtgaaga cgatagacca tccagctgaa
    14761 gagattgcaa aatataatac tatacaagac cagtttgaaa tgcgtaagga agcagttttg
    14821 aatattctta aagaaaatag tatagactta aaatctctta gtgcaatagt aggaagaggt
    14881 ggagttttac caccagtaaa atcaggagca tatttagtaa atgaagaaat gattgatgta
    14941 ctaagacata gaccagtact tgaacacgct tccaatttag gtgctgttgt ggcacatgca
    15001 atatcagaac ctcttggaat caactcatat atttatgatt ctgttgcagt agatgagctt
    15061 atagatgtag cgagaatatc tggactttgt ggaatggata gatcaagtgc agggcatgca
    15121 ttaaatacta gagcaatggc tttaaaatat gctaaggata aaggaaaaga ttataagagc
    15181 ttaaacttaa tagtagctca cattggtgga ggagtaagta tttatcttca tgaaaaagga
    15241 agaatggttg atatgctatc tgatgatgaa ggaccatttt ctccagaaag gtcaggaaga
    15301 gtacctgcta caaaattagt ggctgcctgt tattcaggtc aatattcaga aagagaaatg
    15361 actaaaaaga taagaggtaa aggtggtata gtttcatacc taaatactgt agatgctaga
    15421 gaagttgaaa aaatgatagc agaaggaaat gaagaagcaa aaattattta tgaagcaatg
    15481 gcttatcagt tagcaaaagg tattggagag ttagcaactg tagtagatgg aaaggtagat
    15541 gctataatta taacaggtgg aattgcatat tctgaaatgt ttacttcaat ggttaaaaag
    15601 aaagttgagt ttatagcacc agtagaaatt atggcaggag aaaatgagtt ggaatcactt
    15661 gcttttggaa ctttaagagt actaaatgga gaagaagaag ctagaattta tagtgaaaat
    15721 taataagaaa aactaaaaat gtttatatac taaaaaagtg gtatatccgt tttttataca
    15781 cgaaagctta gagtataggt gaaaatgtat aaaatttgga ttgccacttt ttataattaa
    15841 aattttatct taacctaata aataattctg taaaatttcg tatttatata tatattttat
    15901 tggtatttat tgttattatt attatgagga gtgatttttg atgggaaaaa taagtttaaa
    15961 aagtatgata agattatttt caggtttttt tatatttgca atttcttctg tgcttatgat
    16021 taatgcacat gtaggtctta tgccttggga tgtacttcac caaggtttat ctataaagct
    16081 aggcataact ataggtcagg cttctataat ggtaggagtt gtaattgtta tattggatgc
    16141 agtttttggt gaaaatatag gatggggtac tttactcaac atgacattta taggaatttt
    16201 tattgattta gtaatatttt ctggagtgat acctcatgca agcaacactt atataggtgt
    16261 gtttatggtt gttataggaa ttattttggc agctatagca agttttctat acttaggtgt
    16321 ttgtttagga agtggaccga gagatgggct tatgattgct cttcagaaaa aaactaataa
    16381 atctgtacgt cttgttagaa caattcttga aatactagca ttagttgttg gatggttatt
    16441 aggaggttct gtaggtattg gtacgcttgt aagtgcttta ggtttaggat atgtattaca
    16501 aatagtgttt agaatattta aatttgacac aaaattgctg aaacatagat ttattataga
    16561 tgatataaga gaatggaagg aaaagaaaag caatgaacat aaatgtaaat caagtattgt
    16621 aataaaaaat gagcagaatt aattatgcta aaatatattt gtagtttatc taatttatag
    16681 taaagtcaag gagattttga aatggaatta tgggatttat ataatgctga tggaattaaa
    16741 acaggaaatg ttataaaaag aggtaattct attgaagaag gttattacca tttggcagtt
    16801 gaagtgtgga ttttaaatag taactctcaa attttaattc agaaaaggtc taaaagtaaa
    16861 aaaacattgc caaatatgtg gggaatgaca actggatgta ttgtttctgg ggaagacagt
    16921 ttagaaggag caattcgcga agcaaaggaa gaaataggga tagatataac taaagatgag
    16981 atgaaagttt ttagaagtat gattcatgaa gatactcttt gggatgtata cttagttaaa
    17041 aaagaatatg atatatctaa agctatttta caggaggaag aagtaagtga tataaagtgg
    17101 gtaagcacag atgaaataag acaattacta aaagagggtt tgttttttga atatccagag
    17161 atatacgaat tgctatatga gatagataat aataaattaa atatatgatg tagagcagat
    17221 ttcagtataa gtaagattat ttaaaatgta tcttctctaa attttaatat tgttttatga
    17281 aaattaataa gttattttta gtatttttct acttgttttt tgagattaaa ataaaaaggg
    17341 cagtcattat aaagtcataa aaatttgggg aggatttaaa ctatggaaga taacaaagga
    17401 ttggcacgtg acagttcaaa atataaaatt gtttctatat ctgtcgtagt aattattcta
    17461 attacatttt ggtatatgtt aaatatggtg cttttaacat ttattatgac ttttattttc
    17521 tataacttgc ttgtagccac aagaaaacga attaagaagt tttcttcttt aaatattcca
    17581 gattcattga taattatagt gttatatgca ctatttgcta tattgttagt attgattagc
    17641 tatgcagttg taccaataat tatagttcaa cttacagagt tgagtagggt ttttagtgat
    17701 tttgatgtaa atcaatttgc tcaatcttta ggaccgaaat tgtatcctat tgtctcaaag
    17761 ctggatttta ataaatatat ttcacaagca gggctactta tagcatcaac agcaacaaaa
    17821 gttggaagtt ttggagtaaa tatattattg gcatttttac tgagtttact ccttttactt
    17881 gaaaaaaatg aaattaaaaa ttttggagat aaactttctg atagtaagat ttcttttatt
    17941 tataattcgc ttgtattttt tggaaagagc tttgttaaaa attttggtga agtaatgaaa
    18001 gtacaagtta tgattgcctt tataaattct gttgtttcta tgattttctt aggtttcatg
    18061 ggattccctc aaatatgggc tttaggattt atgatttttg tgttgggtct tattccagta
    18121 gcaggagtta tagtgtcttt gattccatta actgtaatag catttaatac aggaggaata
    18181 acaaaggttt ttggagtttt acttatgatt tgtatagtgc atgcagtaga aacatacata
    18241 ttaaacccta agttgatgtc gaatagaact aaacttccag tttgttttgt ttttattatt
    18301 ttacttgtag gagagcatta tttaggtgta tggggattac taattggagt tccaatattt
    18361 atgttcctta tggatattct gggtgttaaa tttacttcta ggtaatatat taaaataata
    18421 atttattttt atatataaat tatgaattgt tttaaaaaag aacctataaa tagacatcat
    18481 taataaagac atctatttga taggttcaat tttgctttgt ataaatacta taaaactaaa
    18541 taaaaagaaa tttatttcat ttcaaaagtt tcacaacttg catttctttc atttatatga
    18601 actttttcag ctttgcaaag ttcattttta ttgtatttac attttacagc ttcacaatga
    18661 atgttatctg tatcaacttg gttagtttca ttagaacgac tagttatacc agatgtatat
    18721 ttgtcttcaa aagaagcaca ataagtattt tctgtagtag ttgcttgcat tccatctact
    18781 tttatactac cagcataaca atatccacta gtattataag cacaattagt agcagcacaa
    18841 tttaaattat tatttttcat aaataacctc ctaagtttta tttaaactta ttatgtgaag
    18901 ttatctaaat tttatacact tatttacaat tacatttatc acatttaaca actacatctt
    18961 tggaagtttc ccttcctaaa tttttattaa catgatacac atcaacattt tcagttgatc
    19021 cacatataga acatttaaaa ttgttttcta gtagggttct ttctttaaat aacttccaat
    19081 acatagaatt gatgtaatca ttataattta ccttgaggca tgtctcaaga aagtttatgt
    19141 atagattgtc taaatctcct gtatttaatt ctgtatattc tggttcaaaa tattcacaac
    19201 atcctctaaa atcgggcttt gtatctgaaa taacacatct aatatcatat ctatagtcta
    19261 ggctaggccc cttaaatgaa agatgtgtgc aaaaagaaca agatatttct ggtagatttt
    19321 tttcaagttc atgtaattta ttattcataa gtattcctcc aaaaaattta ttttaagtat
    19381 ataaatgaat agattatttt aaaactttta tttatttata ttagagattt aggataaata
    19441 ttccaataag gagtaaatac ttaagtattt attactgtat taaataaaaa agaggcaaat
    19501 ctaacttgag attgcctact tttttatcat tttttaataa aatttattct aagtattatt
    19561 ttatttagat ttagtcagcc aacttagtat ctgctttgct ttttaacttt ctaccagagc
    19621 gtacagttaa aatagcatat aatacagtaa atatggcagc taaaacatat gatatattta
    19681 tgtttaagtt aaatccaatt tgagcattaa atatataact gaatataaca aaggaataaa
    19741 acataccagg aattaagctt ataatataat tcttttcttt tattataagg taaactgtaa
    19801 tcattgcaaa tgcaaatatg gcaatagttt gattactcca agagaagtat ctccacaata
    19861 tattaaatcc agaagcacta agctttgcaa atataaggat ggctatgaca ggaataaata
    19921 tacagattga caatataaca cgatgtttct tttccttttg gtcataatga aagtaatctg
    19981 caagcattaa tcttaaagat cttaaagctg tatctccaga agttattggt aaaacaatta
    20041 cacctattat agctatgata ccaccaatag aaccaagtaa atctcttgca accaaaccta
    20101 ttacatcagg agaacctact aattctttag gtattccttt attgtaaata cccatagcag
    20161 ctgcagccca aatcattgca attaaacctt ctaaaatcat catattataa aaagtagttt
    20221 ttccttcttt ttcatttgaa actgatcttg ctataagagt agcttgagtt gagtggaatc
    20281 cagaaacaat accacaagca actgtaacaa agaatgtagg aataagagga ataccatcag
    20341 gatgaatacc tttccaattt gcaagactta aattagctaa atcataacct tgtgtaaaga
    20401 ttccaattcc aacaccagca gcagataaaa gtagaatagc tccaaatatt ggatatacct
    20461 ttcctatgat tttatcaatt ggaaatagtg ttgcacacaa gtaatataga aagataagtc
    20521 cataaactat ccagacaact ggattattta tagtcgattt catatttaaa atttgagtaa
    20581 caactaaatc cccaggtgta taaataaaaa ctgcaccaac taaaagcatt aaaagacaaa
    20641 ggaatatatt atagacttga aatactttat tacctaaaaa tctactgata agagaaggca
    20701 tttgtgctcc tttttctctt atactaatca ttccactcat atagtcatgc aaagctcctc
    20761 caaatacaca gccgataggt attagtatga atgctattgg accaaacaat ataccttgga
    20821 taggtcctag aattggtcct gtaccagcta tattaagcaa ctcaattaga ctatttttcc
    20881 attttttcat tgggacatag tctactccat cactttgagc aagtgcaggt gtttttctgt
    20941 catctgggcc aaatactttt tcacaataag caccatataa agcacctcct attagtaata
    21001 tagccaagcc gattaagaat gttgtcataa tatcacccca tttataaaat tttttggtct
    21061 ttgtatacat attatctaaa tgtgtagatt tatattgaat ttaattctgg acaacctaca
    21121 aattctataa agtattacaa ctaatataat ttcagaaata aatacatata cataaccatg
    21181 tacttagtat acaggtattt ggtaatattt tcaatgttat agcaataaag aatataaaca
    21241 aaattctgat aatattttac aaaaaaatta aaaaatataa aaattagttt aaatagatgg
    21301 agaaaaaagg aaaatcaatt gagaatataa atgtctatat cttaacaata ttaagaggtt
    21361 taaaattctt gaagaaagaa tagtcaagtg atataatggg tttacaggtg tatatacact
    21421 agtacatata gaaagcggtg caattatgga taaagattta acatatcaaa tcaaagagct
    21481 aaagaaagaa aaaaatgcaa taatacttgc ccatttttat caaccaccag aaatacaaga
    21541 attagcagat gcagttggtg actcatatta tttaagtgag attgctagag attgtaaaga
    21601 agaagtggtt gtattttgtg gagtaaggtt tatgggagaa agtgctaaga tattatcacc
    21661 tgaaaaaact gtattgatgc cagtaagtaa cgctgggtgt gctatggcag atatggtaga
    21721 tgaagaaggc gtgataaaat taaagcaaca gtatccaaat gctttggttg tatgttatat
    21781 aaactctaca gctaaagtta aggcacattg tgatgtttct gttacatctt ctagtgcaat
    21841 taaaatacta gaaaacatag ataataaaga aattatattc cttccagata aaaatttagg
    21901 aggatatatt gcagaacaat ttccagataa aaactttata ttttgggacg gatattgtaa
    21961 ataccataac aatataagag ctgaagaaat aattgagtta aaagataagt ataaaaatgc
    22021 agaagtatta gtacatccag aatgtaaaaa agaaataaga gatttaggag attatgtagg
    22081 tagtacatca ggaataataa aatatgctac taatagtaaa aacaaagact ttataatagc
    22141 aactgaagaa ggtatattac atgaattaaa gaaaaataat cctaataaaa acttttatat
    22201 tcctggtgga aaaatactat gtacagatat gaaaaagaca acattagaaa atttatatag
    22261 tacacttaaa aatatggaaa atgaagttat tgtagaagat gaaatcatgg aaaaggcttt
    22321 aaattcactg cttaacatgc acaaattagc agaaggatag agggatagac ttatgaattt
    22381 agaacaagat gttttaatag ttggaagtgg agtttcagga ttatactgtg cattaaattt
    22441 agataaaagt ttaaatgtgc tagtagtatc gaaatcaaca attgaaaaca acaatacata
    22501 tcttgcacaa ggtggaattt caactgctag aaatattgat gatatagaat cctttgtaga
    22561 agatacaatg aaggctgggc agtataaaaa tagagttgaa gcagttcaag tacttgcaga
    22621 tgaatctata gaaaatgtag gtcagatagt agaatatggt atgcctttag acaaagaaaa
    22681 tggagagata gattacacaa gagaaggagc acatagtgta aatcgaatag ttcatagtaa
    22741 ggataatact ggagaagttg tttttaaaac tttattaaaa gaagctaaaa ctagagaaaa
    22801 tataactctt atagaagatg catatctttt agatatatta aaagatggca ataaatgtat
    22861 aggagctaga atttttaaat ctaaaaaaga gattcatgtt ttttcaaaaa tagtagtttt
    22921 agctacaggt ggaattggtg ggctttttaa aaattctact aatcaaagac atcttacagg
    22981 tgatggaatt gcaatagctt taagaaataa tataaaaata gaaaatttag aatatattca
    23041 aatacatcct acagcctttt atgaagaaaa taatgaaggt aggagaatgc ttatatctga
    23101 atcattaaga ggagagggag ctaaactttt aaataaaaat aaagaaagat ttgtggatga
    23161 acttcttcct agagatgtag tttcaaaagc tatttttgag caaatggaaa aagataaatt
    23221 accttatgtg tatttagatg caacacattt agatagtgaa tatttaatta atagattttc
    23281 ttttatttat aatgaatgtt tagctagagg aacagacata acgaaagaat gtataaaggt
    23341 atctcctgca caacattatt ttatgggcgg gatacatgta gatttggatt caaaaacatc
    23401 tatggaaaat ttatatgcag ttggtgaaat tagttgtaca ggtgttcatg gagccaatag
    23461 attggcaagt aattcattac ttgaagggct tgtattttca aaaagagcag ctaaaaatat
    23521 aaactcagtt atagataatg taaaagttaa gtttatagat gtaccagata tggatataga
    23581 tatagaacag gtaaaaaaag aaaataaaat attagtcata aaagaaattg aaagaacaag
    23641 tgaggatttt ggcgatgaat tatttgatta ttgatagaat gatacaggat gctttgatag
    23701 aagatgttcc aagtgaagat ataacaacta attctattgt ggatgaaaat tctaaatcta
    23761 ctgtagattt aatttgcaaa caagatggta taatagctgg cttaggtgta tttaagagag
    23821 tttttgagat acttggtgat gtagatgtaa aattatataa aaatgatggt gatagagtaa
    23881 agaatcgtga aaagatagct gtattaacag gtagtactag aaacttactt gtaggagagc
    23941 gtgtagcatt gaattattta cagagaatga gtggtatagc tactattaca agtaggtatg
    24001 ttgaaaagct tgaaggtaca aatacaaaat tattagatag tagaaaaacg atacctaatc
    24061 ttagaatatt agataagtat tctgtcaaag taggtggagg atgcaatcat agatttaatt
    24121 tatctgatgg aatattgctt aaagacaacc atattggggc tgctggtagt gttaagaagg
    24181 cagttgaatt agctagaaaa aatacttctt ttgttagaaa gatagaagtg gaagtggaaa
    24241 ctttagacat ggtaaaagaa gcaatagaag ccaatgcaga tataataatg ttggataata
    24301 tgagtttgga aatggcaaaa caagcagtag atattataaa tggaagagcc attgtagaat
    24361 tttccggaaa tgtaaattta gatactatag aagatatagg aaaaattggt gtggatgttg
    24421 tttctgtagg agcgcttaca cattctgtta aagctctcga tataagtatg aagaatttga
    24481 gaaatatata aattttatat tgaaataaac ttaattaaaa tagactcctt aaatttgttt
    24541 tataaattta aggagtctat tttttattca tta
//
LOCUS       DAEQCW010000053        24358 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.053, whole genome shotgun sequence.
ACCESSION   DAEQCW010000053 DAEQCW010000000
VERSION     DAEQCW010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24358)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24358)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24358
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.053"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            107..1480
                     /locus_tag="KRO40_002130"
     CDS             107..1480
                     /locus_tag="KRO40_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2092948.1"
                     /translation="MNEILENIDEGVHFVNKDGKTIIYNNSVQKMEKMNRHDILTNSF
                     FDIVNKMKINRSTLLEVLEKREVIKDNIQKYLDKNGKEITAINTTIPIDIKGEFVGAL
                     EISKNMTTIENLLNRNYKKNLVNKVSSRQKKGYEFDDILGESNLIKEAIAKSKKACKS
                     DASVFIYGETGTGKELFSQSIHYGSNRKNYPFIAQNCAALPESLFEGILFGTSKGGFT
                     GAIDRPGLFEQANKGTLLLDEINSMPIMLQAKLLRVLQEGYVRRVGGTKDIPIDVRII
                     ATTNESPKVILNEHKMRKDLYYRLNIIHIKIPPLRDRKEDIPLLCKKFISKYNKKLNK
                     KVVGISDEAIKILKNYDWQGNIRELENIIYCTMSMMEDEVQIETSMINLNDYYNLKEN
                     KESNNYSLNDLEDKTLSKIISEIEEKYIYESLEKASYNITKAASILGMNRQNLQYKIK
                     KYNIKIL"
     gene            1736..2803
                     /locus_tag="KRO40_002131"
     CDS             1736..2803
                     /locus_tag="KRO40_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-binding protein"
                     /protein_id="HBH2092949.1"
                     /translation="MRKVRVGIWGFGAMGIGMANMILKKEGIEIVSVCSRSTSGKSMY
                     NVLGIERGERPEVIINKNYEEVFREKSVDVVLLATDSFTKKAFDKIIFLLNRKINVIS
                     TAEQMAYPQADDADLAKKMDEVAKENGVSILGTGINPGFVLDLLVLALSGTCEEVTSI
                     KAKRVNDLSPFGKSVMVEQGVGVTREEFIKGVEDKTIAGHVGFVESINMIADGLGWKL
                     DKIEQTKEPIMTTVDRKSKYGEALAGNVAGCRQCGYGYVNGEVLIEMEHPQQIIPEAE
                     GIKTGDYVSIKGIPNIDLQINPEIPGGVGTYAMIVNSIPLIINARPGLKTMLDIPVPR
                     AIMGDIRNQIEVELEEESKAN"
     gene            2924..3232
                     /locus_tag="KRO40_002132"
     CDS             2924..3232
                     /locus_tag="KRO40_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-ketopentanoate thiolase"
                     /protein_id="HBH2092950.1"
                     /translation="MDAKINDWVIIHNIVLTPEERAPQVPEDTKKVSLEMWVKGFIQS
                     DASIGDLVEVKTITGRLVKGNLLKINPYYTHDYGKCIPELLQIGIQAKEILFGGVYNE
                     "
     gene            3225..4655
                     /locus_tag="KRO40_002133"
     CDS             3225..4655
                     /locus_tag="KRO40_002133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent lyase/thiolase"
                     /protein_id="HBH2092951.1"
                     /translation="MNNSTSMKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYE
                     KMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAKEGKGARIFVKDEAMNA
                     SGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNG
                     VGQPEIIEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVET
                     LGYELAIQFREKYKKDPDIVVCTNAGGGNLTGTARGLIKAGSINTKVVGASVDLKGLH
                     MASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVKQGEVFYTT
                     ELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKAIVVQETEYTGAGKHICPQLTFARE
                     NGIDIKFGNPREEIAGVNLILPERPELLKCVDIDMNKIRKSFIKNCISNNHIDNIDKL
                     SNRDIEFLMEEVKSSRDFVVDVLNNL"
     gene            4733..5107
                     /locus_tag="KRO40_002134"
     CDS             4733..5107
                     /locus_tag="KRO40_002134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine aminomutase subunit alpha"
                     /protein_id="HBH2092952.1"
                     /translation="MKKREDDFEVRRKHLQELSDDELKERFWSLATQIVEPMIELGKK
                     NTTPSIERSVLLRMGFSSLEVKPILEGVMERGLIGKGAGHVVYKLAKSKNITVREAGL
                     LLVKGEYWDEVTCLFREGVESC"
     gene            5101..7305
                     /locus_tag="KRO40_002135"
     CDS             5101..7305
                     /locus_tag="KRO40_002135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892628.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBH2092953.1"
                     /translation="MLKENKKLDIDYILKDLDKYKPKRRGWVWREHLENLEMGPFKYK
                     DCTKPLKKSVGLPSSKYFNNIDPQPSPVITTEIASGRFEDDIRRMRMAAHHGADHLMV
                     IRTAGQSHFDGLIEGTPQGIGGVPITRKQVRAQRKALDFIEEEVGRPINYHSYVSGVA
                     GPEVAVMFAEEGVNGAHQDPQYNVLYRNINMVRSFVDACEAKKIMAFANIAQIDGAHN
                     ANATAREAWKVMPELMVQHALNSIFSEKIGIDKSNICLSTVPPTAPPAPCLKIDLPYA
                     VALRELFSDYKMRAQMNTKYMESSTREATVTHVLNLLTSVLTRADIQSTITPDEGRNV
                     PWHIYNIEACDTAKQALVGMDGLMDMIELKDVGELRDKARELKERAVLYMEEISEVGG
                     YFESVEQGFFVDSGNYPERNGDGISRKIKGGVGEGTVYEREEDYLAPVTAHFGYNNVA
                     QYDENAIDNPSMLIDGCTFENPDKIIYIDELDDFDNVENRLKESYEYRNGTKIKPEME
                     WCADGIVMITMMLPTDKRTAEFAALEFVKKMNLQEIEVISREVMHESEGTRIEVKGRV
                     PFDIDLNNLVIPEEPKVLTDEEIRADIEEKPMKIVSATVGEDEHSVGLREIIDIKHGG
                     IEKYGIECHYLGTSVPVEKLVDAAIELNADAILASTIISHDDIHYKNMKKLHDYCVEK
                     GIRDKVMIACGGTQVTPEIAVEQGIDAGFGRNSKGIHVATFLVEKRREMSNK"
     gene            7305..8714
                     /locus_tag="KRO40_002136"
     CDS             7305..8714
                     /locus_tag="KRO40_002136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate mutase L"
                     /protein_id="HBH2092954.1"
                     /translation="MENSKVSLKIDVLVAEIGSTTTVVNAFHDINTNNPIFLGQGQAP
                     TTVFEGGDVRNGLSGAIKDLANKLSVDDIKYNDMFATSSAAGGLKMTVHGLVYDMTVK
                     AAKEAALGAGAVIRQITSGRIKRTDLNKIKEINPNIILIAGGVDYGERDTAIYNAEMI
                     ASMNLGIPVIYAGNVENQEEIRLIFEDTNYKLYITENVYPKIDLLNIEPTRRIIQSVF
                     EEHITTAPGMKYIKEMVNENITPTPGAVMEASKLLYKNIGDLLTLDVGGATTDVHSVT
                     DGSDYINKILVNPEPTAKRSVEGDLGVYVNMKNIVEVIGKENLQSELSIDIDAVIENY
                     PPIPKSKEEILFVERLTKEAVVKAMLRHSGKIRNIYGTTGKVKIAEGKDLTEVRYIVG
                     TGGALTRLPSRIEILDNMLKYNKNNELLFPKEKTKILIDNDYIMASMGVLSKKYEEAS
                     LKLLLKSLNFEEERLCILG"
     gene            8699..9763
                     /locus_tag="KRO40_002137"
     CDS             8699..9763
                     /locus_tag="KRO40_002137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine/ornithine racemase family PLP-dependent
                     enzyme"
                     /protein_id="HBH2092955.1"
                     /translation="MYPRLEIDIEKLKHNAKLISQMCHERNIKISFVTKSFCAQKEIV
                     EEICSEGIDHIADSRIQNLKNLQDINLPKILIRIPMLSELEEVINYCDISFNSELGTI
                     KKLNELCESKNIIHKIVLMFDLGDLREGYFYEEDFFSNVREIVRLKNIEIIGIATNLT
                     CYGAIIPSRENIGRLVSIAKRMEEKFGINLEIVSGGNSSSIHLLINNNMPEGITNLRI
                     GESILLGRETAYGENINGTYQDAFKLICQVVECKEKPSVPIGEIGVDAFRNKPVYEDK
                     GILKRAIIAIGKQDINIDSLIPIDTDIKILGASSDHMILDVSNTKYDYKLGDNLEFLL
                     TYGGIMSSSTSKYVSKKIIV"
     gene            9793..11214
                     /gene="nhaC"
                     /locus_tag="KRO40_002138"
     CDS             9793..11214
                     /gene="nhaC"
                     /locus_tag="KRO40_002138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBH2092956.1"
                     /translation="MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAA
                     AVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILIIIIIGVLIGTWIVSGVVPCMIYW
                     GLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
                     SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSG
                     QALDIKQIELIRSTLDSTFNTLSPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFA
                     VVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTVSLTICALSLGGILE
                     KTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKR
                     GIHPKMLSRALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLV
                     LIACKFKIARIEDEPETCLNFDV"
     gene            11643..12107
                     /locus_tag="KRO40_002139"
     CDS             11643..12107
                     /locus_tag="KRO40_002139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBH2092957.1"
                     /translation="MTRISNITIAEQSEYCFLAIRKTIDFMVEFSEFSKQSFEKISKY
                     LEERGILSSGAPIVCFHNMDLAKLDVEVGFPVATYIDGKNEILQRIVPAQKIITAIDL
                     GPYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPASEYLTKMMLPII"
     gene            12341..12703
                     /locus_tag="KRO40_002140"
     CDS             12341..12703
                     /locus_tag="KRO40_002140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2092958.1"
                     /translation="MKIYDILTRFYIQDIEKAIPFYENLLKEKCSLRFSYKEVGLELA
                     QIGNVLLLSGSDDALKPFIETKSTFMVDSVDEWRSYLLDNGAVVVRDKKKVPTGYNMT
                     LRHPDGTIIEYVQHTKQD"
     gene            13298..14134
                     /locus_tag="KRO40_002141"
     CDS             13298..14134
                     /locus_tag="KRO40_002141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2092959.1"
                     /translation="MSYKVINVITAIDYIEEHLSEKLDLDIVANAVHYSKYHLHRTFT
                     TSVGLTMHDYIKRRKLTEAAKLLAFSKKPIIEIALIAGYESQQAFTSIFKAMYKKSPN
                     KYRKEQEFYPLQLRFVLKKDNLFSKNVLELEKEIKLASMSDIPLWMNLVRLVIDGFPN
                     LQEEEYIYQLEQYILEERALILKLNNVAIANMVFNRETRSIDFFGIHPQYRNSDIAQV
                     FLKKVIEDFLIDTDISITTFREGDKADTGHRDMIKKLGFAEAELLVEFGYPTQKFILP
                     LS"
     gene            14218..16332
                     /locus_tag="KRO40_002142"
     CDS             14218..16332
                     /locus_tag="KRO40_002142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding domain-containing protein"
                     /protein_id="HBH2092960.1"
                     /translation="MSENKQVVNCDIIASNSKHNMCEYDAELLTFFPDEIAHLIEINN
                     KLDNAFKKAENLVDKLDKDYMDAKMYMVKNRGEIDPHEMFQNEQGLKQIDNYGAFMVK
                     VRDKINKIKDSPYFARIDFRLKDMDDESKYYIGRFAFDYEDELIILDWRSPIASMFYD
                     YEIGKAGYDAPIGWVDGEITRKRQFKIKNGKLEYALESSINIQDDILQKELSHTSDEK
                     MKSIISTIQKEQNQIIRNDKADTLIIQGVAGSGKTSIALHRIAFLLYRFKDKISANNV
                     IILSPNKVFGDYISNVLPELGEEPLCELSFENIAEVQLDRVINFESEKDPLEINDAKW
                     SERVRFKSTLDFVKLIDDYIKQMPNKIFIPKDYTFGSFTAKSDWIQSRFEAYNRYPVK
                     KRLEKVAEDIHYKFESDNIMEEDLPKVKSILKSLNGMLTIKNTLTLYKDFFKQMNISN
                     MFVMATKKTLEWSDVYPFIYIHAAYEGIQEDKIIRHVVIDEMQDYTPIQYAVINLLFK
                     CKKTILGDFGQLVNPNHTHTLDDMKQLYNDGELVMLNKSYRSTFEIINFAKKIQDISS
                     LEPIERHGEEPALLKCNNEQDEINKIKIEIEEFKKSDNATLGIILKTDNDAKAVYDAL
                     REKYSVHLISSESSSFTKGVSITSIKMSKGLEFDEVIVPSVNNKTYYSDYDRSLLYIA
                     CTRAMHKLKLTYTGELTQLIDM"
     gene            16873..17826
                     /gene="blaCDD"
                     /locus_tag="KRO40_002143"
     CDS             16873..17826
                     /gene="blaCDD"
                     /locus_tag="KRO40_002143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBH2092961.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYLGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNDKNKKEKINMVDYSDCFEDISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLINKVDAKYVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDVNDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
     gene            18170..18853
                     /locus_tag="KRO40_002144"
     CDS             18170..18853
                     /locus_tag="KRO40_002144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2092962.1"
                     /translation="MEILKCENLTKIYGSNQTRVTALNNVNLSVQKGDFVSIVGASGS
                     GKSTLLHLLGGVDRPTSGKIYVEDTEIASLKEEALAVFRRRKVGLIYQFYNLIPTLDV
                     RKNILLPMLLDKRKVDEDRFSEIVSILGLSDRLNHLPSQLSGGQQQRVSIARSLIYRP
                     AILLADEPTGNLDRKNSEEIVDLLNLSNKRFNQTILLITHDEKIALEANRIVTMEDGV
                     IVSEKVVKK"
     gene            18850..21510
                     /locus_tag="KRO40_002145"
     CDS             18850..21510
                     /locus_tag="KRO40_002145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2092963.1"
                     /translation="MNILQEYTLDFVRRNKRSSIAIMLAILLTTTMMSSLCGLLYTMW
                     TDFIKLSIEKEGNWHGELFDYTYGSDLPLIENFSSVDDVMVKGQWYVGKINDEKRDYI
                     IYRNATSEYWNSMPEKDTIIEGRRPNNANEIALSKQYFENNPSVKIGDKITLPIGDRI
                     LNGKPLEPIAPKSKGESFKKISEATLTIVGKVDVSTSSVIPAYTALGYLDKTSIKPND
                     SITVYLRFKNIRDTYKELPKLAKSLGWKTNEYGKYNLKYNSNYLLKMLVFSPEQKASM
                     SSISKFSTPIMYLTIAIFTVAVFVMVIYNAFSLSANARLTQLGILSSVGASPKQIKRS
                     VVFEGFLLTIIPLPIGLFLGWLLCNRLIVYVNSVNYHTDVPEVVFTYGIPAFLPAVLL
                     TIVTVWISALIPARKVSKISPIEAIRQGDSVKIKKSHKYSLGKIFGIEGELASNALRA
                     RKKSYRTATISLTLSFLLLTCFLHIIANQEGAKAVYGSDNYKDQRDIAVYLENSEPVE
                     SAFIEKLDNTEGVKSSLYYQKMSASTWLTEKDASKELAKNGGFKNIASSKKYSPIERD
                     GKFRIISNIIGLDDKSFTEYCRQISVDPKLFYDTKNPTSIVYNKEEDINRSTRRNKVY
                     IDYLNLSIGDNIKLNEKVYDEDKGDYTYNMKVGAITSTLPKIVDTSSKYTLMQIVPMS
                     MVQEISKNYDEVSRLRSNRLIGVFKVNNREDIPRVREKLESIYNKDYGSGDYSIEDVL
                     ESEKQDASGIKTMNLIVGFITGLLAMIGLSNVLATVSGNIRSRRQEFAMLRSVGLSPE
                     GIKKMLILEGLFLGITPLLLSIPVQIGIVYAFLRINEIYFIEYLPFAPISTIIGFTIL
                     ILFIVIASYMTGYKQLKNENIVESIKNETI"
     gene            complement(21691..22872)
                     /locus_tag="KRO40_002146"
     CDS             complement(21691..22872)
                     /locus_tag="KRO40_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2092964.1"
                     /translation="MKTPRNINSTVVFIIFCLIVTFLLSVILTTITSFNEYNVLSKAL
                     GASYEYNPKSTESILKSLKNSSDKDFKTGNEILSKHGYSKSTFWSKNFFYFLVISFGI
                     ISTMATVVYIIKHRTNKQKLSRINNLTQYLEEVNLGKESVLLRCEDEFSHLEDEIYKT
                     VGELRCSKEFALKERQTLSDNLADIAHQLKTPITSMSLMAQLLSENCPDEEIDYINRL
                     TNQISRLERLVSSLLTLSKLDASTLIFESKLIDVHSLLTYAIEPIEGSLREKHQTFTI
                     EASPSVEFEIDINWTLEALLNILKNCSEHIEDGGYIVAYYSQNPLYVEIIIEDNGKGF
                     AQEELPYIFNRFYRGKNASKDSIGIGLALSKSIIERQNGTIHAENCHNGGARFIIKFY
                     T"
     gene            complement(22872..23534)
                     /locus_tag="KRO40_002147"
     CDS             complement(22872..23534)
                     /locus_tag="KRO40_002147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2092965.1"
                     /translation="MAKILLLEDDDTITFGIKTSLEKKNHTVCCYNTIAEAKKNFDKT
                     IDLILLDLNLPDGIGYEFCQYVKSIEDTPVIFLTVRDDEKDIIRGLDMGADDYVVKPF
                     LLSVLQSRINAVLRRTHSNTNNTITCENISLNKVEVKAYLDNVEVPLTAGEYKLLLSL
                     MENKNRAMTRTKLLEMLWDVDGNFVNDNTLTVTIKRLREKLKNPPCIKTLRGIGYRME
                     DN"
     gene            complement(23666..24304)
                     /locus_tag="KRO40_002148"
     CDS             complement(23666..24304)
                     /locus_tag="KRO40_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2092966.1"
                     /translation="MSELSKRDKEKIQRENEIIDKAEKLFCLNGFDNTTMNELAKEVE
                     YTKRTIYKYFSCKEDLFFAVVLRGYKRLWDNVKIESAKGKTGFEKIKLSYFAFHKFYS
                     VEPSLLCLMGMIGIVNSEKSDTDMLFKEKFFSFNKFMFDEIQGMFEIGKNDRSIRHDI
                     EIPTLMYSSIFTLTGFFNLLSVTGKSYLNNFNIDEEKFIETTLALLIDSIKA"
BASE COUNT         9447 a         2833 c         4309 g         7769 t
ORIGIN      
        1 tatatgataa gataaataca atagcaacat tttattaatt ttttgggttt ttatatattt
       61 aggtactggg gtgatatagt tgaaccaaga gatatttttt aaaataatga atgaaatatt
      121 ggaaaatatt gatgaagggg tacattttgt taataaagac gggaaaacta taatctacaa
      181 taattctgta caaaaaatgg aaaaaatgaa cagacacgat attttaacca attcattttt
      241 tgatatagtc aacaaaatga aaataaacag gagtacacta ttagaagttt tggaaaaaag
      301 ggaagttatc aaagacaata ttcaaaaata tctggataaa aatggaaaag agataacagc
      361 aattaatact acaataccaa ttgatattaa aggcgagttt gtaggggcac ttgagatatc
      421 aaagaatatg acaacgatag aaaatttact aaatagaaat tataaaaaaa atttagtcaa
      481 taaagttagt agtagacaaa aaaagggtta tgaatttgat gatattttag gggaaagtaa
      541 tttgattaaa gaagcaatag ctaaatctaa gaaagcttgc aagtctgatg cttcagtatt
      601 tatatacggt gaaactggaa cgggtaaaga gttatttagc cagtccattc actatggaag
      661 taataggaaa aactatccat ttatagcaca aaattgtgca gctttgccgg aatcactatt
      721 cgaaggtatt ctttttggaa ctagcaaggg aggatttaca ggagcaatag ataggccagg
      781 cttatttgaa caagctaaca aagggacatt gttattggat gagataaatt ccatgcctat
      841 tatgttacag gctaaactat taagggtttt acaagaaggt tatgtaagaa gggttggagg
      901 aactaaggat atacctatag atgtaagaat tattgcaacg acaaatgaaa gtccaaaggt
      961 aattttaaac gagcataaaa tgcgaaaaga tttatattat aggcttaaca taattcatat
     1021 aaaaattcct cctcttagag atagaaaaga ggacatacct ctattgtgca aaaaatttat
     1081 ttcaaagtat aataaaaagt taaataaaaa agtggtagga atttcagatg aagctattaa
     1141 aattttaaaa aattacgatt ggcaaggtaa cataagagag ctagaaaaca taatttattg
     1201 tactatgagt atgatggaag atgaggtaca aatagaaaca agtatgatta atctaaacga
     1261 ctattacaat cttaaagaga ataaagagag taacaattat tctttaaacg atttggagga
     1321 caaaacactt agtaagatta tcagtgagat agaagaaaag tatatatatg aatcattaga
     1381 aaaggcatct tacaatataa ctaaagctgc atcaatttta ggtatgaata ggcaaaattt
     1441 acagtataaa ataaaaaaat ataatatcaa aatattataa ataagcaaga taaaaaaaca
     1501 aaatcaaagt aaaataaaaa agcaaaatag aggagcaaaa ttattataaa agagcaaaat
     1561 attttgctct tttttttatt tctcataaga aatattattt tttatttatg aaaatacata
     1621 ataaaataat tatagtttca acgttccaat aaatatttac tttaatttta aagttggcac
     1681 gatttatgct ttaactaatt attgagaata tataaatttt taggagggtg tatatatgag
     1741 aaaagtaaga gtaggaatat ggggatttgg agctatggga ataggtatgg ctaatatgat
     1801 tctaaagaaa gaaggtatag aaatagtatc tgtttgtagt agaagtactt caggaaaaag
     1861 tatgtataat gttttaggaa ttgaaagagg agaaagacca gaagttatta tcaataaaaa
     1921 ttatgaagaa gtttttagag aaaaaagtgt agatgttgtt ttgttagcaa ctgattcatt
     1981 tactaaaaag gcttttgata aaataatttt cttattaaat agaaaaataa atgttatatc
     2041 aacagcagaa caaatggcat atccacaagc tgatgatgca gatttagcta aaaaaatgga
     2101 tgaagttgca aaggaaaatg gagtaagtat acttggaaca ggaataaatc caggatttgt
     2161 attagattta ctagtattgg cactttcagg tacttgtgaa gaagttacta gtataaaagc
     2221 taagagagta aatgatttat ctccatttgg aaagtctgtt atggtggaac aaggtgttgg
     2281 agtaacaagg gaagaattta taaaaggtgt agaagataag actatagcag gtcatgtagg
     2341 ttttgtagaa tcaataaata tgatagctga tggattaggt tggaaattag ataagataga
     2401 acaaacaaaa gagccaataa tgactacagt agatagaaaa tctaagtacg gagaggcatt
     2461 ggctggaaat gttgctggtt gtagacaatg tggatatgga tatgtaaatg gagaagtttt
     2521 aattgaaatg gagcatccac aacagataat accagaagca gaaggtatta aaacaggaga
     2581 ctatgtatca ataaaaggta taccaaacat tgatttacaa ataaatcctg aaatacctgg
     2641 aggagtaggt acttatgcaa tgatagtaaa ctctattcca ttaataataa atgctagacc
     2701 aggtcttaaa actatgttgg atataccagt acctagagca ataatgggag atataagaaa
     2761 tcagatagaa gttgaattgg aagaagaatc aaaggctaat tagtaagata gcaactagct
     2821 aattagtaag ataacagtta gctaattggt aaaataatgt ttaatttaaa ataacagtaa
     2881 attaattagt aaggcaatag tcaattaata aggggatgaa aaaatggatg ctaaaattaa
     2941 tgattgggtt attatacaca atatagtatt gactccagaa gaaagagctc cacaagttcc
     3001 agaggatact aagaaagtat ccttagaaat gtgggttaaa ggttttatac aaagtgatgc
     3061 ttctataggc gacttagtag aagttaaaac aattacaggc agacttgtaa aaggtaattt
     3121 acttaaaata aatccatatt atactcatga ttatggtaaa tgtataccag agttactcca
     3181 aataggaatc caagctaaag aaatattatt tggaggtgta tataatgaat aattcaacat
     3241 caatgaaaga tatgagttat caagctgtta tgggaagaaa taacgaaata atgaaaaatg
     3301 caatcggatt ggattattct tcttttgaac aagagggaat agggtttgat tatgagaaaa
     3361 tgatgagtga aacaggatat acattacaag atattgaagc aattcaatca cagtatgctg
     3421 ttggaaatac tcctttaata gagcttaaaa atttgactaa attagctaga aaatgtgcta
     3481 aagaaggtaa aggagctaga atatttgtaa aagatgaagc aatgaatgca tctggtagtt
     3541 ttaaagcaag aagagcagct actgcagtat atcatgccaa acaaatggga tataaaggtg
     3601 taatagcagc tactagtggt aactatggtg cagctgtagc atcacaagcg gcaatgcagg
     3661 gattaaaatg tataatagtt caagaatgtt atgattctaa tggtgtaggt caacctgaaa
     3721 tcatagaaaa agcgcgaaaa tgtgaggcat atggagcaga agttgttcag ttaactgttg
     3781 gaccagagtt attttatacg ttcttagttt tattagaaga aacaggctat tttaacgcat
     3841 cattatattc accatttgga attgcaggtg tagaaacttt aggttatgag ttagctatcc
     3901 aatttagaga aaagtataaa aaagaccctg atatagttgt ttgtacaaat gcaggtggtg
     3961 gtaatcttac tggaactgca agaggattga taaaagctgg ttctattaat actaaagtag
     4021 taggagcaag tgtagattta aaaggattac acatggctag tgataatcaa tttaataaaa
     4081 aatcatttac aacaggacat acaggttttg ggataccata ctgtacatgg cctgataggt
     4141 cagatgtacc taggtctgca gctagaccac ttagatatat ggatagatat gtattagtaa
     4201 aacaaggaga agttttttat acaactgaat tattggcaca gctagaaggt atagaaagag
     4261 gtccagcagg aaatacatct ttagcagcag cattctcttt agctcaagag ctagatgagg
     4321 ataaagctat agtggtacaa gaaacagaat atacgggtgc aggtaaacat atatgtccac
     4381 aacttacctt tgcaagagaa aatggaatag atataaaatt tggaaatcca agagaagaaa
     4441 ttgcaggagt aaacttaata ttaccagaaa gaccagaatt attgaaatgt gttgatattg
     4501 atatgaataa aataagaaag tcatttataa aaaattgtat atctaataat cacattgata
     4561 atattgataa gctaagtaat cgagatatag aatttttaat ggaagaagta aaaagttcaa
     4621 gagattttgt tgttgatgta ttaaataatt tatagtaatt attgtttttt aatttaatat
     4681 aaaataaaaa ttcagaaaat tcgattaaat caatacgaat ggaggaatgt tcatgaaaaa
     4741 aagagaggat gattttgaag ttagaagaaa acatcttcaa gaactgagtg atgatgagtt
     4801 aaaagaaagg ttttggagtt tagctaccca gatagtagaa ccaatgatag aacttggtaa
     4861 aaagaataca acaccatcaa tagaaaggtc tgtcttgttg agaatgggat tttcttctct
     4921 tgaagtaaaa cctattttag aaggggttat ggaaagaggt cttataggta aaggagcagg
     4981 gcatgtagtt tataaattgg ctaaatctaa aaatataacg gttagagaag caggtttgtt
     5041 attagttaag ggtgaatatt gggatgaagt tacatgttta tttagagaag gggtagaatc
     5101 atgttaaagg aaaataaaaa attggatata gactatatat taaaagattt ggataaatat
     5161 aaaccaaaac gaagaggttg ggtttggaga gaacacttgg aaaatcttga aatgggacct
     5221 tttaaatata aagactgtac aaaaccttta aagaagagtg tagggctacc atcatctaag
     5281 tatttcaata atatagaccc tcaaccaagt ccagttatta ctactgaaat agcttctggt
     5341 agatttgagg atgatataag aagaatgaga atggcagctc atcatggagc tgaccatcta
     5401 atggttatca gaactgctgg acaatcacat tttgatgggc ttatagaagg aactccacaa
     5461 ggtataggtg gagttccaat aacaagaaaa caagtaagag ctcaaaggaa ggctcttgat
     5521 tttatagaag aagaagttgg tagacctatt aattaccatt catatgtaag tggtgttgct
     5581 ggtcctgaag tagcagtaat gtttgctgag gaaggagtca atggagcaca tcaagaccca
     5641 caatataatg ttctgtatag gaatataaac atggtaaggt cttttgtaga tgcttgtgag
     5701 gcaaagaaaa taatggcttt tgccaatata gctcaaattg atggagcaca taatgctaat
     5761 gctactgcta gagaagcatg gaaggtaatg cctgaactta tggttcaaca cgctttaaac
     5821 tctatattct cagaaaaaat aggtatagat aaaagtaata tatgcttatc aacagttcca
     5881 ccaacagcac ctccagcacc atgtttaaaa atagacttac cttacgcggt tgcacttaga
     5941 gagttattta gtgattataa gatgagagct caaatgaata ctaaatatat ggaatcatca
     6001 actagagaag caacagttac tcatgtatta aacttattaa catcagtatt aactagagct
     6061 gacatacaat caactataac acctgatgaa ggtagaaatg taccttggca tatatacaat
     6121 atagaagcat gtgatacagc aaagcaagct ttagttggta tggatgggct tatggatatg
     6181 atagaactta aagatgtcgg tgaattaaga gacaaagcaa gagaacttaa agaaagagct
     6241 gtattatata tggaagaaat atctgaagtt ggtggatatt ttgaatctgt ggaacaagga
     6301 ttttttgttg attctggaaa ttatccagaa agaaatggtg atggaatatc tagaaaaata
     6361 aaaggtggag ttggtgaagg tactgtttat gaaagagaag aagattattt agcacctgta
     6421 actgctcact ttggatacaa taatgtagct caatatgatg aaaatgctat agataatcca
     6481 tcaatgttaa tagatggatg tacatttgaa aatccagaca aaataatata tattgatgag
     6541 cttgacgatt ttgataatgt agaaaataga ctaaaagaat catatgagta cagaaatgga
     6601 actaaaatta agcctgaaat ggaatggtgt gcagatggaa ttgtaatgat aacaatgatg
     6661 cttcctactg ataaaagaac agcagagttt gcagctttgg aatttgtcaa aaaaatgaac
     6721 ttacaagaaa ttgaggtcat aagtagagaa gttatgcatg aatctgaagg gactagaata
     6781 gaagtgaaag gaagagttcc gtttgatata gatttaaaca atttagtaat accagaagaa
     6841 cctaaggtac taactgatga agaaataaga gcagatatag aagaaaaacc tatgaaaata
     6901 gtttcagcta cggttggaga agatgaacat tcagttggtt taagagaaat aatagatata
     6961 aaacatggag gtattgaaaa atatggcata gaatgccact atctagggac ttctgtacct
     7021 gtagaaaaat tggtagatgc agcgattgaa ctgaatgcag atgcaatact tgcatctaca
     7081 ataataagtc atgatgatat tcactataaa aacatgaaaa aattacacga ttattgtgta
     7141 gaaaaaggta taagagataa agtaatgatt gcgtgtggag gaacacaagt aacacctgaa
     7201 atagctgttg aacaaggcat agatgctgga tttggaagaa acagcaaagg catacatgta
     7261 gccactttct tagttgaaaa aagaagagaa atgagtaata aataatggaa aatagcaagg
     7321 tttctttaaa aatagatgtg ttggtagctg aaattggaag tactactaca gtggtaaacg
     7381 ctttccacga tattaatact aacaatccta tatttttggg tcaaggtcaa gctccaacaa
     7441 cagtgtttga aggtggcgat gtaagaaatg gcttatcagg tgctattaaa gatttagcta
     7501 ataaattatc tgtagatgat ataaagtata atgatatgtt tgcaacttct agtgcagctg
     7561 gtggattaaa aatgactgtt catggattag tctatgatat gacagtaaaa gcagctaaag
     7621 aagcagcttt aggggctgga gctgttattc gtcaaataac atcaggtaga attaaaagaa
     7681 ctgatttaaa taaaataaaa gaaataaacc caaacataat tttaatagct ggtggagtcg
     7741 attatggaga aagagataca gctatttata atgcagaaat gatagcttct atgaatctag
     7801 gcataccagt tatatatgct ggtaatgttg aaaatcaaga ggaaataagg ttaatatttg
     7861 aagatactaa ttataagctt tatataactg aaaatgtata ccctaaaata gatttattga
     7921 atatagaacc tacaagaaga atcattcaaa gtgtatttga agaacacata actacagcac
     7981 caggaatgaa atacattaaa gaaatggtta atgaaaatat tactccaacc ccaggagctg
     8041 taatggaagc ttctaaactt ttatataaaa atattggaga tttattaact ctggatgtag
     8101 gtggagcaac tactgatgta cattctgtta cagatggaag tgactatatt aataaaattt
     8161 tggttaatcc tgaacctact gcaaagagaa gtgttgaggg ggatttaggt gtatatgtaa
     8221 atatgaagaa tatagtagaa gttataggta aagaaaactt acaaagtgaa ctatctatag
     8281 atattgatgc agtaatagag aattatcctc caataccaaa atcaaaagaa gaaatattat
     8341 ttgttgaaag attgacaaaa gaagctgttg ttaaagctat gctaagacat tcaggaaaaa
     8401 taagaaatat ctatggaaca actggaaaag tcaaaattgc agaagggaaa gatttaacag
     8461 aagtaagata tatagttggt acagggggag cacttactag gctccctagt agaattgaaa
     8521 tattagataa tatgctcaaa tacaataaaa ataatgaatt actatttcca aaggaaaaaa
     8581 caaagatatt aatagataat gactatatta tggcatctat gggtgtttta tctaaaaaat
     8641 atgaagaagc atctcttaag ctcctgttaa aaagtttgaa ttttgaggag gaaagattat
     8701 gtatcctagg ttagaaatag atatagaaaa gttaaagcat aatgcaaaat taatttcgca
     8761 gatgtgtcat gaaagaaata ttaagatatc ttttgttact aaatcatttt gtgcacaaaa
     8821 agaaatagta gaagaaatat gtagtgaagg aatagaccat atagcagatt caagaataca
     8881 aaacttaaaa aatttacaag atataaatct acctaagata ttgattagaa tcccaatgtt
     8941 aagtgaatta gaagaagtta tcaattattg cgatattagt tttaactcag aattaggaac
     9001 aataaagaaa ttaaatgaat tatgtgaaag taaaaatatt attcataaga tagttcttat
     9061 gtttgactta ggcgatttac gagaaggata cttttatgaa gaagactttt ttagtaatgt
     9121 aagagagata gtaagattaa aaaatattga aataattggt atagctacaa acttaacctg
     9181 ttatggagct attataccat ctagggaaaa tataggcaga ctggtaagta tagcaaaaag
     9241 aatggaagaa aaatttggaa taaatctaga aatagtatct ggaggtaatt caagttctat
     9301 tcatctgttg ataaataata atatgccaga aggtattact aatttgagaa taggcgagtc
     9361 cattctactt ggtagagaaa cggcatatgg tgaaaatata aatggaacat atcaagatgc
     9421 atttaaatta atatgccaag tagttgaatg taaagaaaaa ccatcagttc ctattggaga
     9481 aataggagtt gatgccttta gaaataaacc tgtttatgaa gataagggaa tcttaaaaag
     9541 ggcaatcata gctataggta aacaagatat aaatattgac tctttaattc caatagacac
     9601 tgatataaaa atattagggg caagttcaga ccacatgata ctagatgtaa gtaacacaaa
     9661 atatgattat aaattaggtg acaatttaga atttttatta acttatgggg gtatcatgtc
     9721 atctagtacg agcaaatatg tttcaaaaaa aattatagtg tagtgtttaa ataattagga
     9781 ggaaactatt ttatgaaaga gcgagaatgt agaaaagcaa gtctgtttga tgcaatgata
     9841 ccaattactt gtttgatatt atttttaagt ctaggagtat tagtgtatgg ttcatcacct
     9901 catgtaccac taataggagc agcagcagta gcaggacttg tggctgtata tagacttgga
     9961 tttaaatgga aagagttaga attaagtatg tttaatagta taaagatggc aatgcaagca
    10021 atcttaatca taattataat aggcgtactt ataggaactt ggatagtaag tggagtagtt
    10081 ccatgtatga tttactgggg actaaaaatt ttatcaccaa atattttttt agtagcatca
    10141 acattagtct gtgcaatagt atctcttgcg acaggttcat cttggagcac aatgggtaca
    10201 gtaggagtag ctcttttagg cattggtcaa agtttaggta tgccaattgg attaatcgta
    10261 ggttctataa tatctggagc ttactttgga gataaactat cacctttatc tgaaacgact
    10321 aacttagctc cagcaatggc aggaacagat ttgtttacac atataaaata tatgctatat
    10381 tcgactatac catcattatt aatttgttta gtaatttatg gtgtaattgg aatgaagtat
    10441 tcaggtcaag cactagatat aaaacaaata gaattaatta ggtctacatt agattctaca
    10501 tttaatactt tatcaccagt attattatta gctccagcaa tagtaattgg attggttgta
    10561 tttaaagttc ctgctatacc agggcttata gtaggtgctg tattgggagt attgtttgca
    10621 gtagtttttc aaggagaatc tatgaatacg atattagatg cagcacaaaa tggatatgtt
    10681 tcgtcaacac aaatacagga ggtagatgct ttattatcta aaggtgggat tatgaatatg
    10741 atgtccactg tatccttaac aatatgcgct ttatctcttg gaggtatttt agaaaaaaca
    10801 ggtatgcttg aagtagtagc atcttcttta ctaagattag caaagggtgt atttggaaca
    10861 gtattatgta ctatggtaac ttgtacaatt accaatataa tagcaggtga acaatatcta
    10921 tctatagtta taccaggaag aatgtataat aaggaatata aaaagagagg tatacatcct
    10981 aagatgttgt cgagagcttt agaagatagt ggaactttaa cctctccatt agtaccatgg
    11041 aatacatgcg gggcgtatat aacagcaaca ttaggtgtat ctgcactaac atatggtcca
    11101 tacgctttat taaatattat aaatccaata gtatctttag tattaattgc atgtaagttt
    11161 aaaatagcaa gaatagaaga tgaacctgaa acttgtttaa attttgatgt ttgataatag
    11221 ataacttatg taagaacgta ggaactaggg gggtagcctg tggggaatta gtaagacata
    11281 ttttagtgtg cgaaattcta taaatcagta atcttgtgac tttagccatg ggaggttcag
    11341 attagtaaat ttatagtttt atattagtct atattttgat cttttaattg tttgtataaa
    11401 ttttttatag aaaaagattt cttttagact tgcctaaaaa ttaggcaagt cttttaagta
    11461 tgttctgatt ataagagcac tgtgtgacaa gaatgatgag attatttttg ctatactttc
    11521 gatataagaa atggaaggag gttatgtttt atattcatat gaaataatta gttacacagt
    11581 aaattttcgt ataatttggt ataaaaagat tagaaatgaa aataaagtaa tggaggaata
    11641 aaatgactag aatatccaat ataacaatag ctgaacaatc tgagtactgt tttttggcaa
    11701 tacgaaaaac aattgacttt atggtagagt tttcagagtt ttcaaaacaa agttttgaaa
    11761 aaatttctaa atatctggag gagagaggaa ttttatcttc aggagcaccg attgtatgtt
    11821 ttcataacat ggatttagca aaattggatg ttgaagtagg gtttcctgta gccacttata
    11881 tagatgggaa aaatgagatt ctacaaagga ttgttcctgc acagaaaata ataactgcaa
    11941 ttgatttagg accttatgaa ttacaagacc ctactttaga agacttattt tcatgggcaa
    12001 atagcaatgg atataaactt catggcgata tatattacca gtatttaaat gatatcaatc
    12061 gtccagctag tgaatatctt acgaaaatga tgttacccat tatatagaaa gttaaagatt
    12121 atcgtttgtt agttgataat tagaagaaca tttactgcta ctacataaat tttatcctaa
    12181 ataatatcaa ggtgatttaa tttatgtatt ctaatgtaac cccaatatat tgttaaggtc
    12241 tacttaagat gctcaaaagg ctatgcttaa tttattgtta tataatttgt agagtggtat
    12301 aatttagagg taatattata tagatatata gggggaaaat atgaaaatat atgatatatt
    12361 aacacgtttt tatattcaag atatagaaaa agccatacct ttttatgaaa atcttttaaa
    12421 agaaaaatgt tctttgcgtt tttcctataa agaagttggg ttggaattag cgcaaatagg
    12481 aaatgtttta ctattatctg gttctgatga tgctcttaaa ccatttatag aaacaaaatc
    12541 tacttttatg gttgattctg ttgatgaatg gagaagttat ctattggata atggagcagt
    12601 tgtagtaaga gataagaaaa aagttcctac aggatataat atgacattga gacatccaga
    12661 tggtacaatt atagaatatg ttcaacatac aaagcaggat tagttaaaaa cagattttac
    12721 tactgagcaa ctaattagaa tctattctta gacgtacaat ttattatttt tggtattaac
    12781 agattataag tcaaattata atatttcaaa atagaataga aatttattta cataaaagag
    12841 agtgtttaaa aatgaacttt ttagttcatg aagcactctt ttttgtatga aatcaaatac
    12901 atcaatatat aaaataaact gatgaagagc ttaaattaaa ataaaaagat tcataacagg
    12961 accccattaa actttaagat agggtaagtt tgtaatcata ttaaataatt gtaaaaagct
    13021 gtttttagtc gtataatata aatatttatc atttaattaa ggaatataaa aggaatctaa
    13081 taagaagaaa ataataaata actttttaga tttactaaat gaaaaattat tgaaaattaa
    13141 aggattagag tctttaatca gaaagtaaaa agtaatatat taaatttatg aattgaaaac
    13201 ttaaacaaca aatttgttta taaaatagca agattcatta aatataacta agtaataatt
    13261 gatataatgt tgcatggata aaaggaggga agctgcaatg tcttacaaag taattaatgt
    13321 cataactgct attgactata tagaggagca tttatcagaa aagctggatt tagatatagt
    13381 tgctaatgct gttcattact caaaatatca cctgcataga actttcacaa cttctgttgg
    13441 cctaacaatg catgattaca taaagcggag aaagttgaca gaagcagcaa aattattggc
    13501 attttcaaag aaaccaatta ttgaaattgc attgatagct ggatatgaaa gtcaacaggc
    13561 attcacttct atatttaaag ctatgtataa aaaatctcca aataaatata ggaaagaaca
    13621 agaattttat cctttgcagc taagatttgt tttgaaaaaa gataacctat tttcaaagaa
    13681 tgtactagag ttggaaaaag aaattaaact tgcaagtatg tctgacatac cattatggat
    13741 gaatttagtg agattagtca tagatggatt tccaaattta caagaggaag aatatatata
    13801 tcaattagaa cagtatattt tagaagaaag agctttaata ttaaaactta ataatgtcgc
    13861 tattgcaaat atggtgttta atagagaaac tagaagtatt gatttttttg gaatacatcc
    13921 acagtatcgt aattcagaca ttgcacaagt gtttttgaag aaagttattg aagatttctt
    13981 gatagataca gatatttcaa ttactacctt tcgagagggt gacaaagctg atacaggaca
    14041 tagagatatg ataaagaagt tgggctttgc agaagcagag ttgcttgtgg aatttggata
    14101 tcctactcaa aaatttattc ttcctttaag ttaaatagca agaatgatta aaaactccaa
    14161 aacacaatta agtataatga ttcagtgtaa gtacttaatt aacaaaggag gatttaaatg
    14221 tctgaaaata aacaagtagt aaattgcgat attattgcat ctaattctaa acataatatg
    14281 tgtgaatatg atgcagagtt attaactttt tttccagatg agattgcaca tctaatagag
    14341 ataaataaca agctagacaa tgcttttaag aaagctgaaa atcttgttga caagcttgat
    14401 aaggattata tggacgctaa aatgtatatg gtaaaaaatc gtggtgaaat agacccacat
    14461 gaaatgtttc aaaatgaaca aggactaaaa caaatagata actatggggc ttttatggta
    14521 aaagttcgag ataagattaa taaaatcaaa gattctccat actttgctag aatagatttt
    14581 aggctgaaag atatggatga tgaatctaag tattatattg gtagatttgc atttgattat
    14641 gaagatgagc ttataatact tgactggcgt tctccaattg ccagtatgtt ttatgattat
    14701 gaaatcggaa aagctggata tgatgctcca ataggatggg tggatggaga aataacaaga
    14761 aaacgacaat ttaaaattaa aaatggaaaa ttagaatatg cactagaaag ttccattaat
    14821 atacaagatg atattcttca aaaagaactt agtcacactt cagatgaaaa aatgaagtca
    14881 atcatttcaa caatacaaaa ggaacaaaat caaattatta gaaatgataa agctgataca
    14941 ctgattattc aaggggtagc tggttctggg aaaacatcta tagcattaca cagaattgct
    15001 tttcttcttt atcgatttaa agataaaata tcagcaaata atgtaattat cctatcacct
    15061 aataaagtct ttggagacta tatttccaat gtccttcctg agcttggaga agagccatta
    15121 tgtgaattaa gttttgaaaa tatagcagag gtacaattag atagagttat taattttgaa
    15181 agtgagaaag acccattaga aataaatgat gctaaatggt ctgaaagagt gcgttttaaa
    15241 tctacacttg attttgtaaa acttattgat gattatataa aacaaatgcc aaataagatt
    15301 tttattccaa aagactacac ttttggaagt tttacagcta aaagtgactg gatacagagt
    15361 agatttgagg catataacag atatccagtt aagaagagat tagagaaggt agctgaagac
    15421 attcattata aatttgaatc agataatatt atggaagaag atttaccaaa ggtaaaaagt
    15481 atacttaaaa gtttgaatgg aatgttgaca ataaaaaata ctcttacact atataaggat
    15541 ttctttaaac aaatgaatat atcaaacatg tttgtgatgg caacaaaaaa aactcttgaa
    15601 tggtcagatg tatacccatt tatatatatt catgctgcat atgaaggtat acaagaagat
    15661 aagattataa gacatgttgt tattgatgaa atgcaggatt acacacctat tcaatatgct
    15721 gtaataaact tactttttaa gtgtaaaaag actattcttg gagattttgg acaattggtt
    15781 aatcctaatc acactcatac actagatgat atgaaacagc tatataatga tggggaacta
    15841 gttatgttga ataagagtta ccgttctact tttgagatta ttaatttcgc caaaaagatt
    15901 caagacatat cttcattaga gcctattgaa cgacatggtg aagaaccagc tttattaaaa
    15961 tgtaataacg agcaagatga aataaataag ataaaaatag aaattgaaga atttaaaaag
    16021 agtgataatg cgactcttgg tattatatta aagacagata atgacgctaa agctgtatat
    16081 gatgcgttaa gagaaaaata tagtgttcac ttaatatctt ctgaaagttc tagctttaca
    16141 aaaggagtat ccataacttc tattaaaatg tcaaaaggtt tagagtttga tgaagttatt
    16201 gtaccttcag taaataataa aacatattat agtgattatg accgcagttt gttatatatt
    16261 gcttgtacac gagctatgca taaacttaag ttgacatata ctggtgaatt gactcaactt
    16321 atagatatgt agattatata cttattatgt aagtgtttac ttatataaat ataacctgtc
    16381 aataaaattc attaataaat caataaaaac aatatttgta aaagtaaaag ctataaatta
    16441 tatattaaat tttataattt atagctttta taatactgct tatcttaatc ctcccaatag
    16501 caaaataatt ttaaacatgc catattttat aaatgtaata acaattatac aattaaaata
    16561 actttcccaa agtaacttga catttaaaac ttactattgt aatatttaaa tattacaata
    16621 gtaagtttta aatgtggaat caattattat atcacaaatt aaaaggagga caggatgtta
    16681 ttaatagtta cctaattatc ttcgcaatag gtttaatcaa cataattgta ctaggtgaag
    16741 aaaatataag agatacagct attcatttag tcttgtttct tataagtaga acctagattg
    16801 gagtatatta caaataatgt atactatttt aatagtaggt tataaattta aatatgggag
    16861 atgatataaa ttatgaaaag aaaaaagaat tttatttgga tagctatctt attggttggt
    16921 gtagttatgg taatgtatta tttagggaaa aaacataacg atataaatca aaaaactgat
    16981 aagaattata taaaatctga attaaataag tctgaattaa ataaatccaa aattgaaaac
    17041 aatgataaaa acaaaaaaga aaaaattaat atggttgact atagtgattg ttttgaagat
    17101 attagtggag gagctatttt ttataatact aaaaataaag aatataatat atataacaaa
    17161 gaattaattg aaacaagaag gtcaccatgt tctactttta aaatagtttc aactttaatt
    17221 ggtttagaaa aaggggtaat aaattcaaaa gaatcagtta tgggatatga tggtacagag
    17281 tatccaaata aaaattggaa taaaaatctt agtttagaag aggcatttaa ggagtcttgt
    17341 gtttggtact acaaaaaatt gataaataaa gttgatgcta aatatgtcca aaacatttta
    17401 gatgatttaa agtatgggaa ttgcgatatt agcgaatggg aaggagattt aaaaaatgga
    17461 aagggacatt taaatggatt ttggttagaa tcttcattac aaatatctcc aaaagaacaa
    17521 gtgcaaacaa tggcaaaaat atttgaggga gatacaaact ttaaaaaaga gcatattaat
    17581 attttaagag atattatgaa aatagatgta aatgataaaa acataaatgt atatggaaaa
    17641 actggaacag gatttgatga aaaaaataaa cgtgtggatg catggtttgt tggtatgcta
    17701 gagcgtgaag gtgacaccta ttattttgct attaaatcag atgattccaa taaagaaatt
    17761 acagggccaa aggtaaagga aattgcaatt aatataatta agaaatatta tagtgtaagg
    17821 gaataaactt aattttattt gtaaatatta tttacctata gtctgtaata tttattaaat
    17881 aattttacta aattgagtct atatagagca aaactccttt agtacataaa atacttgcta
    17941 ttgattatta aattgaatac ctatagattt aaagttaata ccttttaaag actatgtaat
    18001 atattaaaag tataaataaa atatattgca tagtctttgt tttatattat aattttaaat
    18061 aatgtgcaaa aactaaacaa tatttttaat agtaatttat atttgtattc atgtcactat
    18121 aatgtcattt taggttgcta aaatttaacc ataaaggaga tgattgtata tggaaatatt
    18181 aaaatgtgaa aatctcacaa aaatatatgg ttcaaatcaa accagagtga cagcccttaa
    18241 taatgtaaat ttatcagttc aaaaaggtga ttttgtatcc attgtaggag catctggttc
    18301 tggcaaatct acattgttac atctgcttgg gggagtagat agacctacat ctggaaagat
    18361 ttatgttgaa gatacagaaa tagcaagttt aaaggaagaa gctcttgcag tttttagacg
    18421 tagaaaagta ggtcttattt atcaatttta taatcttata cctactcttg atgttagaaa
    18481 aaatatatta ttacccatgt tacttgataa aagaaaggtg gatgaagata gattctctga
    18541 gattgtatct atattgggat tatctgatag attaaaccat cttccaagtc aactttcagg
    18601 tggacaacaa caaagggtat ctatagctag aagtttaatt tatagaccag ctattttatt
    18661 agcagatgag ccaactggta atctcgatag aaaaaattca gaagaaattg tagatttgtt
    18721 aaacttatca aataaacgat ttaatcagac aatacttctt attactcatg atgagaaaat
    18781 agcactagag gcaaatcgta ttgtaactat ggaagatgga gtgattgtct ctgaaaaggt
    18841 ggtgaagaaa tgaatattct tcaagaatac accttagact ttgtacgacg caataaacgt
    18901 agtagtatag ctataatgtt agctatatta cttactacaa ccatgatgtc ttctttgtgt
    18961 ggactgttgt ataccatgtg gacagatttt ataaaacttt caattgagaa agaaggtaac
    19021 tggcatggtg aattgtttga ctatacttat ggaagtgact taccattaat tgaaaatttt
    19081 tcttcagttg atgatgtaat ggtaaaagga caatggtatg taggcaaaat taatgatgag
    19141 aaaagagatt atataattta tagaaatgct acatcagagt attggaattc tatgccagaa
    19201 aaggatacta taatagaggg tcgtcgacca aataatgcta atgaaattgc attatcaaaa
    19261 caatattttg agaataatcc aagtgtaaaa attggggata aaattactct cccaatagga
    19321 gatagaatcc taaatggaaa gcctcttgaa cccatagccc caaaatcgaa aggggaaagt
    19381 tttaaaaaaa tttcagaggc tacattgaca atagtaggaa aggtagatgt ttctacttca
    19441 tcagtaatac ctgcatatac agctcttgga tatcttgata aaacaagtat aaaacctaat
    19501 gatagtataa ctgtgtactt gcgatttaaa aatataagag acacgtataa ggaacttcca
    19561 aaacttgcta aatcattggg atggaagact aatgaatatg gaaaatacaa tcttaaatac
    19621 aatagtaatt atcttttaaa gatgttagtc ttttcaccag aacagaaagc atctatgagt
    19681 agtatatcaa aattttcaac tcctattatg tatcttacaa tagcaatttt tacagtagcc
    19741 gtgtttgtaa tggtgattta caacgcgttt tcactgtctg caaatgctag acttactcag
    19801 ttagggatat tatctagtgt tggtgcatca ccaaaacaaa ttaaaaggtc tgtagtgttt
    19861 gaaggctttt tactgacaat tataccatta ccaataggtt tatttttagg atggttattg
    19921 tgtaataggc ttatagttta tgttaattca gttaattatc atactgatgt tccagaagtg
    19981 gtatttactt atggtattcc tgcttttctg ccagcagttt tacttacaat agtaacagtc
    20041 tggatttctg cacttatacc agcacgaaaa gtatcaaaga tatctcctat agaagcaata
    20101 cgacaaggag atagtgttaa aatcaaaaag tcgcataaat attcattagg aaagatattt
    20161 ggaatagaag gagaacttgc atcaaacgca ctacgtgctc gtaaaaaatc ttatcgtact
    20221 gcaacaatat ctttaacatt atctttttta ttacttacat gttttttgca tataattgcc
    20281 aatcaagaag gagcaaaagc tgtttatgga agtgataatt ataaggacca aagagatata
    20341 gcagtttatt tggaaaatag tgaacctgta gagtctgctt tcattgaaaa attagataat
    20401 acagaaggtg taaaaagttc actatattat caaaaaatgt ctgcttccac ttggttgact
    20461 gaaaaagatg cttcaaaaga acttgcgaaa aatggaggat ttaaaaatat agcttcatct
    20521 aaaaagtact ctcctataga acgtgatgga aagtttcgta taatttcaaa tataattggg
    20581 cttgatgata agagttttac agaatattgt aggcaaattt ctgtagaccc aaagttattt
    20641 tatgatacaa aaaatccaac ctcaattgta tataataagg aggaagatat taatcgtagt
    20701 acacgtagaa ataaagtata tatagattat ttaaatcttt caataggaga taacattaaa
    20761 ttaaatgaaa aagtatatga cgaagataaa ggggattata cttacaacat gaaagtggga
    20821 gctattacaa gcacacttcc taaaatagta gatactagtt caaagtatac attaatgcaa
    20881 atagttccaa tgtctatggt gcaggaaata tctaaaaatt atgatgaagt aagtaggtta
    20941 cgttcaaata ggctgatagg agtatttaaa gtaaataatc gtgaggacat tcctagagta
    21001 agagaaaaat tagagtccat ttataataaa gactatggtt caggagatta tagtattgag
    21061 gatgttttag aaagtgaaaa acaagatgct agtggaataa agaccatgaa tttaatagta
    21121 ggctttatta caggtttatt ggctatgatt ggattatcaa atgtacttgc tacagtgtca
    21181 ggaaatatta gaagtagacg acaagagttt gctatgttgc gttctgttgg attatctcca
    21241 gaaggcataa aaaagatgct tattttggaa ggtttattct taggaattac accattacta
    21301 cttagtattc ctgtgcaaat aggaatagtg tatgcttttc tacgtataaa tgaaatatat
    21361 tttatagagt atttaccatt tgcacctata tctacaataa taggttttac tatattgata
    21421 ctttttattg taatagcatc atatatgaca ggatacaagc agttgaagaa tgaaaatata
    21481 gtagaatcta taaaaaatga aacaatataa acaaaatcta tttgaactta tttaaaggtt
    21541 tcgatttaag actacttaca agtataggga tagttaagtt gtttgtttaa taaaacctta
    21601 aatgtaaata gaagtatatt actaaaacaa tagataacat agaatataga tatagctgga
    21661 ttataggtat tttacctata atccagcatt ttatgtgtaa aatttaatta tgaatcttgc
    21721 accaccatta tggcaatttt ctgcatgtat agtaccattt tgacgttcta taatagactt
    21781 tgatagagca agccctatac caatactgtc cttactagca tttttaccac gataaaatct
    21841 attaaaaata tatggaagtt cttcctgagc aaacccctta ccattatctt ctatgataat
    21901 ctcaacatat agaggatttt gactataata agcaactata tatccaccat cttctatatg
    21961 ctcactacaa tttttaagaa tatttaaaag agcttctaaa gtccaattaa tatcgatttc
    22021 aaattctacc gaaggagaag cctcgatagt aaatgtctga tgtttttctc ttaaagaacc
    22081 ttctataggc tcaattgcat aagtaagaag agaatgtaca tctataagtt tgctttcaaa
    22141 tattaaagta cttgcatcca attttgataa tgtaagtaaa gatgaaacta gtctctcaag
    22201 tcttgagatt tgatttgtaa gtctgttaat ataatctatt tcttcatctg gacaattttc
    22261 tgaaagtaat tgtgccataa gtgacataga agtaattgga gtcttaagtt gatgagcaat
    22321 atctgcaaga ttatctgaaa gagtttgtct ttcttttaaa gcaaattctt ttgaacaacg
    22381 aagttcccca actgttttat atatctcatc ttcaaggtga gaaaattcat cttcacatcg
    22441 taaaagtaca gactcttttc ctaaattcac ttcttctaag tattgagtaa gattgtttat
    22501 tctactcagt ttttgcttat ttgttctatg tttgattata tatacaactg tagccattgt
    22561 tgaaattata ccaaacgata tcactagaaa ataaaaaaag tttttactcc aaaatgtact
    22621 tttagaatat ccatgttttg ataaaatttc atttcctgtt ttaaaatcct tatcactaga
    22681 atttttcagt gattttagta tactttctgt agacttagga ttgtactcat atgatgcacc
    22741 aagagcctta gacagtacat tgtattcatt aaaagaagtt atagttgtta gaattacact
    22801 caataaaaaa gttacaatta agcagaatat tataaaaaca actgtactgt tgatatttct
    22861 tggagttttc actagttgtc ctccattcta tatcctatgc ctcttaatgt ttttatacaa
    22921 ggtggatttt ttaatttttc tctaagacgt tttattgtaa cagtaagagt gttatcattt
    22981 acgaaattac catctacatc ccagagcatt tctagtaact ttgtacgagt catagctcta
    23041 tttttatttt ccataagact tagaagaagt ttatattctc ctgctgtcaa aggtacttca
    23101 acattatcta aatatgcttt gacttcaacc ttattcaagc ttatattttc acatgtaata
    23161 gtattgttag tatttgaatg agttcttcta agaactgcat taattctgga ttgaagtact
    23221 gagagcaaaa acggtttaac cacatagtca tctgcaccca tatctaatcc acgtataatg
    23281 tctttttcat catcacggac tgtcaaaaat atcactggag tatcttctat acttttaaca
    23341 tattggcaaa actcgtatcc aataccatca ggtagattta aatcaagcag aattaaatca
    23401 atagttttat caaaattttt tttagcttca gcaatcgtat tataacaaca tacagtgtga
    23461 tttttctttt caagggaagt ttttattcca aatgtaattg tatcatcatc ttctaaaaga
    23521 agtattttag ccatttactt ttaatccttt cagtaattta gttattccat taactaagtt
    23581 attagtttta tgtttaatat tttttatatt agagatagaa aaaattatca tttaagtata
    23641 taaactttaa tttataaact taggtttatg ctttaattga atctattaaa agagcaagag
    23701 ttgtttcaat aaatttttcc tcatctatat taaagttgtt caggtatgat tttcctgtta
    23761 cagatagtaa attaaaaaat cctgtaagtg taaatattga tgaatacata agagtaggta
    23821 tttcaatatc atgcctaata cttctatcat tttttccaat ttcaaacatt ccttgtattt
    23881 catcaaacat aaatttatta aaagaaaaaa acttttcttt aaacagcata tcagtatccg
    23941 atttttcaga gtttacaata ccaatcattc ccataaggca taatagagaa ggttctacag
    24001 agtaaaattt atgaaaagca aagtatgaaa gttttatttt ttcaaaccct gttttgcctt
    24061 ttgcactttc tattttaaca ttatcccaaa gtcttttata tcctcttaag acaacagcaa
    24121 agaataaatc ttctttacat gaaaagtact tgtatatggt gcgtttagta tattcaactt
    24181 cttttgctaa ttcattcata gttgtattat caaatccatt aagacaaaat aatttttctg
    24241 ccttatcaat aatctcattt tctctttgta ttttttcttt atctcttttt gataattctg
    24301 acatataaat tattcctttc tattgataaa aaagtatact gatggtatac ttatgtaa
//
LOCUS       DAEQCW010000054        24205 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.054, whole genome shotgun sequence.
ACCESSION   DAEQCW010000054 DAEQCW010000000
VERSION     DAEQCW010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24205)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24205)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24205
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.054"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            109..300
                     /locus_tag="KRO40_002149"
     CDS             109..300
                     /locus_tag="KRO40_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF378 domain-containing protein"
                     /protein_id="HBH2092967.1"
                     /translation="MKKVALILAIIGALNWGAIGILGTDLIGSIFGGTYEMVSRIIYF
                     IVGLAGLYLIPSLMSDDRE"
     gene            455..1864
                     /locus_tag="KRO40_002150"
     CDS             455..1864
                     /locus_tag="KRO40_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2092968.1"
                     /translation="MFIINELNKIVNEEVISFHMPGHKKGQVYKKLGYKDILKNLYKM
                     DTTEILGTDNLHFPEGIIKNSQKKASRVFKSDYTCYLVNGSSCGIQSAIMSVCSPKSK
                     IITNRDCHQSVINGCILGDIDIEYVPCEISEETNVLKGISISNVIDIIDKNLDAKAVL
                     LTYPTYYGMTYDLEYICNYAHSKKMVVIVDEAHGAHLGLSERLPKTALEQGADIVVQS
                     THKTLPAFTQSSMIHIQGDRVDIDKILNMLRITESSSPSYLLLSSLELAVDIYENKGK
                     ELMEELLNNIITFKNKVDSNINIYDTNDKTKIFISSKNMGLTGYELENILRNKYNIQV
                     ELSNYYGVLLICTIGNTVEDFSSLETALNNIVKEDFKFEKLENKKYPVVIPKKILTPR
                     EAFYKTKKSVKIYDSIGKVCGECIVPYPPGISVISPGEVISKEIIDYLMFCHSKGMIV
                     SGLKDVDLNFIQIIDLEDI"
     gene            1995..2684
                     /locus_tag="KRO40_002151"
     CDS             1995..2684
                     /locus_tag="KRO40_002151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate kinase"
                     /protein_id="HBH2092969.1"
                     /translation="MKGKLIIIESGSDASGKATQTEILYERLKKEGYMIKKVEYPNYE
                     SPSSALVKMYLKGDFGKNASDVDPYIASTFFTADRYASFKTDWEEFYNEGGIIIADRY
                     TTSNMVHQASKMDICDREEYLNWLADYEFNLFKIPQPDCVIFLDVPIEFSKKLMENRK
                     NKITGEEKKDIHESDIEYLEKSYNNALYIADKYDWKKINCVLDNKLRSIESIHNEIYK
                     IVLDSIKPMER"
     gene            2687..3622
                     /locus_tag="KRO40_002152"
     CDS             2687..3622
                     /locus_tag="KRO40_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HBH2092970.1"
                     /translation="MYFENIIGQDFAKKYLTNSIKKNKLNNAYMFEGMDGIGKKKFAD
                     ELSKLLLDYENLENSPDYVLIKPDGNSIKIAQIRNLQSDIVIRPHKDYKIYIINNAEK
                     MTVEAQNALLKTLEEPPNYAIIILVTNNKESLLETIKSRCDIIKFSPIPIEDLKRYLI
                     NTGIEEERAQLLAIFSRGSIENALNLSQSSEFSMMREDIQQYIQIMLDKNIVEILNIP
                     NNMEKYRGKIIALLDMMINYFRDIILLKENVNKNMLINVDKLVFIQNMSGKISYSQLS
                     KIIDIIEDAKSKIKSNCNFNISIQVMSLNIYEVIK"
     gene            3619..4512
                     /locus_tag="KRO40_002153"
     CDS             3619..4512
                     /locus_tag="KRO40_002153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage 0 sporulation family protein"
                     /protein_id="HBH2092971.1"
                     /translation="MIKIVGIRFKSAGKIYYFDPVDFNIEQDMDVVVETARGLEYGKV
                     VVGPKDMDESELVSPLKPIIRIATEEDKKVYLENKEKAKETFELCQQKIKEHELTMFL
                     IDCEYTFDRNKLIFYFTAEGRIDFRELVKDLAAIFKTRIELRQIGVRDEAKSIGGLGP
                     CGRKLCCSSWLGDFQPVSIKMAKDQSLSLNPTKISGICGRLFCCLKYEHDVYSEAIEK
                     MPVVGALVQSDDGKGKVVEVNPLLEQIKVEFQDKTVKIYTREDIKILREPKKCDGCGG
                     KCKDNDGLDEATLRELKKLED"
     gene            4590..5336
                     /locus_tag="KRO40_002154"
     CDS             4590..5336
                     /locus_tag="KRO40_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HBH2092972.1"
                     /translation="MQLKDSERIDDLQLKGLKIIQDTNGFCFGIDAVLLANFTKIKKD
                     AKVVDLGTGTGIIPILIAGKSEAKKIIGVEIQEDVYEMATRSIKLNGLEERVEIINED
                     IKYIDKVLDINGYHVVTSNPPYMHIDGIKNPNDKKAISRHEVRCNLEDVIRAASRLVM
                     PRGKFFMIHRPTRLVDIITLGRKYKLEPKVIQFVHPRPQKAPNLVLVQFVKDGRPELK
                     ILDPLYVYGEDGNYTKELKAIYNNKDIGEL"
     gene            5337..6170
                     /gene="rsmI"
                     /locus_tag="KRO40_002155"
     CDS             5337..6170
                     /gene="rsmI"
                     /locus_tag="KRO40_002155"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HBH2092973.1"
                     /translation="MSGKLYICPTPIGNLEDITYRTLRTLKEVDLIAAEDTRHSIKLL
                     NHFEISKPLTSYHEHNKDSKGDYLINKLIDGENIALISDAGMPGISDPGEEIIKQAIQ
                     NNIEIEVLPGATAFVTALVGSGMDTHRFVFEGFLDRDKKVRKAQLEELKEESRTIIFY
                     ESPHRLKDTLKDMLKILGNRNISINRELTKKYQEIIRENIETTIKIFEEKEVRGEFVL
                     IVEGFHGEKSKKENYDGLTDREYVLKLIESGMNKKDAIKIVCKDRKLKKDVVYKQVLD
                     L"
     gene            6193..6897
                     /locus_tag="KRO40_002156"
     CDS             6193..6897
                     /locus_tag="KRO40_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HDIG domain-containing protein"
                     /protein_id="HBH2092974.1"
                     /translation="MEIGKIIIESLKREDTHKIFIELDNKHELEKIIPKISCMKSVGE
                     CKYHVVNCFEHSINALKELEIVLNDKDFFPIHLRKHVSNYLNTYIEEGINKLHVLKLG
                     TFLHDIGKPDSMTLDETGRVHFTNHEKIGAQIIDNMGIKLELSTETYRLISKYVRYHM
                     ILLSLYKKNDLSRKELINVFNLVDEDTIGVIMLGYADIVSTVKLLGKSGEVSVLKTYM
                     EYILTNYLYKSNYTHV"
     gene            complement(7085..7513)
                     /locus_tag="KRO40_002157"
     CDS             complement(7085..7513)
                     /locus_tag="KRO40_002157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007287587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBH2092975.1"
                     /translation="MDVTDYRIIEILQDDGRISMKDLGKIVGLTSPAVSERVKRLEES
                     GVIEGYKAIVNPDSLGRVIKAFIHISLPSNGYTEFIESAAKDPRIVECHHITGDDCLL
                     LKVIVKDMYELENVIDTIKKIGSTKTSVILSTPIQAKSIL"
     gene            complement(7550..8980)
                     /locus_tag="KRO40_002158"
     CDS             complement(7550..8980)
                     /locus_tag="KRO40_002158"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HBH2092976.1"
                     /translation="MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGY
                     TIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKFLKFLKEFKFTGDIYAVEEGTIM
                     FPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
                     GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADV
                     YPDKCLLLVDTYDVLNSGVPNAIKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLD
                     NAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFDSPSLGGVYKLAASC
                     EKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFH
                     PTYTWKTKVFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSK
                     PHIYKVDLSRNLWYLKTQMIDSKKVL"
     gene            9112..9696
                     /locus_tag="KRO40_002159"
     CDS             9112..9696
                     /locus_tag="KRO40_002159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein A"
                     /protein_id="HBH2092977.1"
                     /translation="MIIIGKIWFYMVSIGIIGSLISKNMGELNKVILSETSKGIEFAI
                     SLAGIMALWMGIMNIAKESGLIEKIGQKLNPIMRRLFPSIPKGHKAMSYIVMNIALNM
                     LGAGNGATAFGLKAMSELQTLNNKKDTATNDMIMFMVINISSIQIIPFTIIKLRMDMG
                     AQNPSEIIFTTLFATIISTAVAIITCKFFQRRYR"
     gene            9712..10233
                     /locus_tag="KRO40_002160"
     CDS             9712..10233
                     /locus_tag="KRO40_002160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein"
                     /protein_id="HBH2092978.1"
                     /translation="MEIFSNLLIPIIILYIVVYGKYKKIDVYDSFVKGAIDGLKAAWD
                     ILPYIIGIFLAIGIFKTGKGLDMLEWLFTPIANMMSIPKELIGLISVKPLSGSGALGM
                     YSELANRVGIGSLVEKMGATIVGSSETIFYTMAIYYGSLKIKNTRHTLSCAMISHVAG
                     VIAAVFICYVIFV"
     misc_binding    10299..10545
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            10629..12566
                     /gene="metG"
                     /locus_tag="KRO40_002161"
     CDS             10629..12566
                     /gene="metG"
                     /locus_tag="KRO40_002161"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HBH2092979.1"
                     /translation="MSKPSFYVTTPIYYPSGGLHIGHTYSTVAADTIARFKRFCGYDV
                     KFLTGTDEHGEKIQKKAIEQGMSEIEYLDGMIKDIKALWNTMDISYDDFIRTTEKRHT
                     DIIQKIFTKLYEQGDIYKGEYEGRYCTPCESFWTESQLLEGNKCPDCGRETYLVKEES
                     YFFRLSKYEDRLKELFKDDSFCFPAARKNEMVANFLDKGLEDLSVTRTTFDWGIKVPF
                     DEKHVIYVWVDALCNYITALGYMTDNDEEFKKYWPANVQIVGKEIVRFHTIIWPALLM
                     ALGLEVPKQVFGHGWILFADDKMSKSKGNVVYPEPIIERYGIDTLKYFLLREFAFGQD
                     GSYTHRNFVTRINYDLANDLGNLISRTVAMVEKYNNGIIPTAKVSTNFDADLKEQAVS
                     TRENFEAEMDKMQFHEALESVWKLVRRTNKYIDETMPWALAKDETKKDELDTVLYNLC
                     ESIRIIATLINPIMNETANKIYEHIGIKGQDDITTWESTKTFGLIGENVKVFKGEPLF
                     PRLDVEKEIEELTKMFSGKPPVEEKPLEHKEEITIDDLDKIELRVGKIISCEKHPKAN
                     KLLVSQVKIGPETRQIVSGIAEYYKPEDLVGKEVTVVCNLKPVKLRGVESQGMILAAG
                     DDGDPYVLPFTQGAKDGCEVR"
     gene            12596..13366
                     /locus_tag="KRO40_002162"
     CDS             12596..13366
                     /locus_tag="KRO40_002162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HBH2092980.1"
                     /translation="MLFDSHAHLNDESFDEDRDELIGSLKDKGVDLVVNPGADIETSI
                     TAIELAKKYDFIYSAVGVHPHDVSKLDDTAIETLRKLATENEKVVAIGEIGLDYYYDY
                     SPREEQKEWFKKQIELANELKLPIIIHDRDAHGDTFEIIKNTKNPEIGCVLHCYSGNV
                     ELAREYVKMGCYISIPGTVTFKNNKKTREVVREIPLERLFIETDSPYMSPEPHRGKRN
                     NPSQVSFVADKIAQEKGISYEEVCRVTKENAKKFFNIK"
     gene            13703..14134
                     /gene="phnG"
                     /locus_tag="KRO40_002163"
     CDS             13703..14134
                     /gene="phnG"
                     /locus_tag="KRO40_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnG"
                     /protein_id="HBH2092981.1"
                     /translation="MYTVDSTKILINMNLEKLEKIYSMIKDTSSISIIKEPNLATVMV
                     RANESVKNTTFNLGEILVTECSVKVDESLGYGIVSENNNKKAIYLAVIDAVLHSNNSK
                     FDELKNYINKSVYEENLRYEQEIIDEFSLINKTKVQFNAMD"
     gene            14149..14724
                     /gene="phnH"
                     /locus_tag="KRO40_002164"
     CDS             14149..14724
                     /gene="phnH"
                     /locus_tag="KRO40_002164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnH"
                     /protein_id="HBH2092982.1"
                     /translation="MVNYTQEIYRKMLDSASFPGKLNNIDNINIENNTKLLNGAIGIA
                     ITLLDQEVTFYIENYTQKDIKNIRALTMSNQIDYRKSDYIFLDINSEVDILQIKIGSF
                     EYPDESATIVHQVNDLSTYSQTKYIKLDLSGPGIKSKNSIYINGIREEFIERLSSINK
                     DYPIGIDLILVDKKGEIAFIPRSSKLSWEVL"
     gene            14727..15812
                     /locus_tag="KRO40_002165"
     CDS             14727..15812
                     /locus_tag="KRO40_002165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-phosphorus lyase complex subunit PhnI"
                     /protein_id="HBH2092983.1"
                     /translation="MAYVAVKGGEEAILQAKNILEFYRVKGDSLPIDVKQIEEQMSYA
                     VDKVMSEGSLYNKELSALAIKQAQGDILEASFYVRALRSTMPRITYSEPINTEEMRIK
                     RRISATFKDIPGGQYLGATRDYENRILNVELLEEDEKKNRHFRDSFINELETVDEIPE
                     FTKISNIFRKENLLQEEVCENKLEEVIDDITRNSLRFPVSRSAKLQALTRGESGVVSG
                     FAYAIVRGFGDEHPYISELRTGNVFIKVKHPIYEDEEIIIGDMLVTECEIVSKASQNK
                     TENSKTNSEDKNKMSLGYGLCMGNNENKAISMAILDKSLEPNSEKLAQDEEFVLLHID
                     GIDSLGFISHFKLPHYVDFKADVERIK"
     gene            15832..16701
                     /locus_tag="KRO40_002166"
     CDS             15832..16701
                     /locus_tag="KRO40_002166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-phosphate
                     C-P-lyase PhnJ"
                     /protein_id="HBH2092984.1"
                     /translation="MIYNYGFLDENTKKEIRRKILKAISIPGYQVPFGSRELPIAKGW
                     GTGGLQLTLSLIGKNDVVKVIDQGSDDSTNACNIRSFIASVSNVETTKDTLEATLIQT
                     RHRIPEEKLKSNQILIFQVPIPETLRIVEPSEVETRRMHSEEDYSRMWVYLYEDIVRF
                     NDISIAVEYPCKVNDRYLMNPSPIPRFDIKKLNMSDNLFLFGAGREKRIYAIPPYTKV
                     EPLEFEDYKFEEEKFEGKYCSLCNSTNTFLDEVYDSDTNEKYYSCSDTSYCEKVRLKN
                     NSIDVTIGGTWNE"
     gene            16694..17560
                     /locus_tag="KRO40_002167"
     CDS             16694..17560
                     /locus_tag="KRO40_002167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2092985.1"
                     /translation="MSKINDSKRLENIDKQVLIGRNINLIYGDGCEKCFESTGYESNN
                     ICKYCGSIVACNNVNLELYEGEVLGIVGESGSGKSTLLKILFFQEHANSGEVYISHYN
                     KDTNILELSDQKKRYIKNHFMGIVYQNPHLGLNLDFSSGGNIAEKLLMANLYNVEKIR
                     DRGKELLIKTNIPVERIDHKPKYFSGGMQQRVQIAKALSNNPPILLLDEVTTGLDVSV
                     QAEVLDLIREIQRELKISMIVVSHDFDVIKMLADRTIVMKNGSVIESGLTDQIMEDPQ
                     HPYTQQLINSLL"
     gene            17601..18310
                     /locus_tag="KRO40_002168"
                     /pseudo
     CDS             17601..18310
                     /locus_tag="KRO40_002168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
     gene            18311..19480
                     /locus_tag="KRO40_002169"
     CDS             18311..19480
                     /locus_tag="KRO40_002169"
                     /EC_number="3.6.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate
                     5-triphosphate diphosphatase"
                     /protein_id="HBH2092986.1"
                     /translation="MIKLIHNANIVLEDMILENGHLIIEGDTIKKVSNDKIDYAFDFN
                     EIDEIIDAKNLYVIPGIIDIHSDAIEKEIEPRPSTLLPFNMAFYELDKKLPANGITTV
                     YHSISLGDGVGVRSIDNSLKMIKNIDSYKNIDSKSINHKVHLRYEVLYYEGLEKVLEL
                     LDENKIDYLSIMDHSPGQGQYTNPTFYKEYATKVWGVTENYVDTWLDDLVNLHDNLDW
                     NKIANIIGIAKTKNINVASHDDDTLEKMDFIKNIGINVSEFPITLEVAKHSKKLGVLT
                     CLGAPNIVRGKSHNNNLKAMDAILEDCCDIVCSDYLPSAMIKSMCIVAERINNLNKAV
                     SLFTSNPAKAVGIYDERGSIKENKKADLVLVDIDSEYPKVVNTIVNGKTVYKREV"
     gene            19484..20320
                     /locus_tag="KRO40_002170"
     CDS             19484..20320
                     /locus_tag="KRO40_002170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBH2092987.1"
                     /translation="MLTELHCHTSISDNNFTTEEIIKKAAEKNINILAITNHDTLSGL
                     DEALVLGEHYGITIIPGIEISAYDYKNRKRVHILGYNIDLNSQEIKNLCNPMVCDRHK
                     ASVKMVNKIIDLGYKISLEDVKKYSSKTGIFKQHIMKALIDKGYTDNIYSNLYKELFH
                     RGNGKVYVSLKYVDYRDAIKAIKNSGGICVLAHPGQMDNFSAIEEMVKVGLDGIEVYH
                     PSHNKELEKESLSYAKKYNLVVTGGSDYHGFYSQHNYELGSKSLNKEDLFKFRLALGG
                     VL"
     gene            20321..21316
                     /locus_tag="KRO40_002171"
     CDS             20321..21316
                     /locus_tag="KRO40_002171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2092988.1"
                     /translation="MSFLQVKNVGKSYGQVKVLKDISIDIEKGEFICLLGPSGCGKST
                     LLRIIAGLEDKHGGKIIINDKDMTNSPPESRNFGIVFQSYALFPNMNVYKNIAFGLEN
                     KNISKSNIDKKVKEVLEVVELSGYEKKYPSQLSGGQQQRVALARAIALEPDFLLLDEP
                     LSALDAKVRLKLREQIRSLHRKLGITTIMVTHDQEEALCLADKMVVMNRGEIIQVGTP
                     KEVYKNPETPFVADFIGTINFIDDGINKIAIRPEDIKVESNRDSKDKDIKVGEILDIE
                     FRGFNYRITVEYRSKQMKLDVVSKVAEQMKLCIGSKINFKIPKEGIVQYKSEGCA"
     gene            21334..23022
                     /locus_tag="KRO40_002172"
     CDS             21334..23022
                     /locus_tag="KRO40_002172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBH2092989.1"
                     /translation="MITSKNKRRISDSTIQKYFLIFSVIVLIVFILFPLVSLLKNAFM
                     DTSGNFIGISNFSKYVENPSLIASFKNSIFVSTVSSLISLCLAFIYSYAITRTNIKFK
                     EFFKTMGMFPLFAPTMLYGISLIYLFGNKGIFTTMGLEVPLYGPLGIIISQILFTFPQ
                     AFLILSVALSMADYRLYEAADSLGASEFKKFCKITIPGIKYSLLSSFFVSFILAFTDF
                     GAAKVVGGNYNVLATDIYKQVVGQFNIPMGATVSMVMLIPVLIAFTLDKMASKKQGMT
                     ITAKSMPYKIKENKFRDRVFLIVCSFITLLIFILIFVSVIGSVIKLWPYNLSFTMEHY
                     TFKGILGSGIKTYLSSLKISTLTAIFGTIFVFFSAYMIEKVDKFPKLRQTAYLLSMIP
                     MALPGLVLGISYITFFNSASNPLNFLYGSTAILVIVNVVHFYSVCFITSNSSLKMLDK
                     EYELVAKSINIPFYKVFFNITVPMSITSILEIVVYYFVNSMVTVSALIFLYTPQTQTA
                     SISILKLDEIGYIGPSAAMAVLVLLTNIIVRLLYEFVTKKLKNNTQKWQQKDVA"
     gene            23034..24101
                     /locus_tag="KRO40_002173"
     CDS             23034..24101
                     /locus_tag="KRO40_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2092990.1"
                     /translation="MKFKKLVSLGVLSTLLLSVITGCSTDSSGSDSKSDSKTKGDLTV
                     YTAIEEDSIEPYLATFKEKYPDIKLNIVRASTGDITARLLAEKDNPQADVVWGVAATS
                     LLVADDQGMLEPYAPKGSEEIESAFKDDKEVPSWVGIDAWMTGITVNTKELSDKNIPV
                     PSSYEDLIKPEYKGLISMPNPSSSGTGYLTVSALIQIMGEEKAWQYMDKLHENIGVYT
                     QSGSAPATSAASGEYPIGISFGYRGIKLKEEGYPVEVVFPKEGSGWDIEANALVKKDN
                     IKEASKVFLDWAISKDAMNEYSKNYAVTTISTGNPIPEGFPKKPLEQMIDNDLKSAAK
                     NREDILNKWISKYDGKTEKES"
BASE COUNT         9665 a         2711 c         4322 g         7507 t
ORIGIN      
        1 ttttttgtca aaaaaaacaa aaaatacgta tttctttttt catttcggga aaactaaaca
       61 caggaattat ggactttata aaaatttaat tcttgaggag tgatataagt gaaaaaagtt
      121 gctttaattt tagctataat aggtgcgctt aactggggtg caattggtat tctaggtaca
      181 gacttaatag gtagtatctt tggtggaaca tatgaaatgg taagtagaat aatatacttc
      241 attgtaggtt tagctggatt atacttaata ccaagtttaa tgtctgatga tagagaataa
      301 tttatgcttt tatgttaaat acctcattct aaatgtttag aatgaggtat ttaattttat
      361 aaaaatatta atttgtttct tttttaatgg taaaatagat aagaattgaa gttttaaaaa
      421 gaagtattat gtaaaaaagg agtactatta atatatgttt attattaatg aattaaataa
      481 gattgtaaat gaagaagtaa tatcttttca tatgcctggt cataaaaagg gacaggttta
      541 taaaaagtta ggatataaag atatactaaa aaatttgtat aaaatggata caactgagat
      601 attaggaaca gataatttac actttccgga aggaattata aaaaattcac aaaaaaaagc
      661 atcaagagta tttaaaagtg attatacttg ctatttagta aatggtagta gctgtggaat
      721 acaatctgca ataatgtcag tatgtagtcc taaaagtaaa ataataacaa atagagactg
      781 tcatcagtct gttataaatg gatgtatttt aggagatata gatatagagt atgtgccttg
      841 tgagataagt gaagagacaa atgtcttaaa agggatatct ataagtaatg tgattgatat
      901 aatagataaa aacttggatg caaaagcagt actgcttact tatcctacat attatggaat
      961 gacatatgat ttagaataca tatgtaatta tgcacatagc aaaaagatgg tagtgatagt
     1021 agatgaagca catggtgcgc atttagggct tagcgagagg cttcctaaaa cagctcttga
     1081 gcaaggcgca gatatagttg tacagagtac acataaaact cttccagcat ttacacaatc
     1141 gtcaatgata catatacagg gagaccgagt tgatatagat aaaatattga acatgttaag
     1201 aattacagaa tcttcaagcc cttcatattt attattatct tctctggaat tagcagtaga
     1261 tatatatgaa aataaaggaa aagaattaat ggaagagctt ttaaataata ttataacttt
     1321 caaaaataaa gttgattcaa atattaatat atacgacaca aatgataaaa caaaaatatt
     1381 tatatcatct aaaaatatgg gtttaacagg ttatgaacta gaaaatattt taagaaacaa
     1441 atataacata caagtggagt tatctaatta ttatggagtt cttttaatat gtacaatagg
     1501 aaatactgtt gaggatttct ctagtttaga aacagcatta aacaatattg taaaggaaga
     1561 ctttaaattt gaaaagttag aaaataaaaa ataccctgtt gttattccaa agaaaatatt
     1621 aacacctaga gaagcatttt ataaaactaa aaaaagtgtt aaaatatatg acagcatagg
     1681 taaagtttgt ggtgaatgta tagttccata cccacctgga ataagtgtaa tatctcctgg
     1741 tgaagtaata agtaaagaaa taatagacta tctaatgttt tgtcattcta aaggcatgat
     1801 tgtgagtgga ttgaaagatg tagatttaaa ttttatacaa ataatagatt tagaagacat
     1861 ttaaaaatta tgatataaaa gtagatagaa gtagatagtt taaaattgtg aagagaaata
     1921 aatagactgc ttatatagag ctatctaata aaagtactaa aaaagtaaaa agtgtttgta
     1981 tggaggatat gaaaatgaaa ggtaagttaa taattataga gagtggttca gatgcaagtg
     2041 gaaaggctac tcagacagaa atattatatg aaagattaaa aaaagaaggc tatatgatta
     2101 aaaaggtaga atatccaaat tatgaatctc catcatctgc cttggtgaaa atgtacctaa
     2161 aaggagactt tggtaaaaat gcatcagatg tagacccata tatagcatca acttttttta
     2221 cagctgatag gtatgcatca tttaaaaccg attgggagga gttttacaat gaaggtggaa
     2281 taattatcgc agatagatat acaacctcta atatggtaca tcaggcctct aaaatggata
     2341 tttgtgatag agaagagtat ttaaattggt tagctgatta tgaatttaat ttatttaaga
     2401 taccacaacc tgattgtgtt atatttttag atgtgcctat tgaatttagt aaaaagctta
     2461 tggagaatag aaaaaataaa attacagggg aagaaaaaaa ggatattcat gaaagtgaca
     2521 tagagtattt agagaaatct tacaacaatg ctttatatat agcagataaa tatgattgga
     2581 aaaaaataaa ttgtgtttta gataacaaat taagaagtat tgaaagtata cataatgaaa
     2641 tttataaaat agttcttgat tcaataaaac ctatggagag ataaatatgt attttgaaaa
     2701 tattataggg caagattttg caaagaaata tttaacaaat tctataaaga aaaataaact
     2761 taataatgcg tatatgtttg aaggaatgga tggaatagga aaaaagaaat ttgcagatga
     2821 attatcaaaa ctattacttg attatgaaaa tctcgaaaat agtccagact atgtactcat
     2881 aaaaccagat ggaaatagta taaaaatagc tcaaatcaga aatttacaat cagatatagt
     2941 aataagacct cataaagact ataaaatata tataatcaat aatgctgaaa aaatgactgt
     3001 ggaagctcaa aatgcacttt taaagacgct agaggaacct ccaaactatg ctataataat
     3061 cttagtcaca aacaacaagg aatctttatt agaaactata aaatctagat gtgatataat
     3121 aaagttctca cctataccaa ttgaagactt aaaacgttat ttgataaata caggtataga
     3181 agaagaaaga gctcaattat tggctatttt ttcgagagga agtattgaga atgctctaaa
     3241 tctatctcag tcttctgagt tttcaatgat gagagaagat atacaacagt atattcagat
     3301 aatgttagat aaaaacatag tggagatttt aaatatacca aataatatgg aaaaatatag
     3361 aggtaagatt atagctttat tagatatgat gataaactat tttcgagata tcatcctatt
     3421 aaaagaaaat gtaaacaaga acatgttaat aaatgtagat aagctagttt tcattcaaaa
     3481 tatgagtgga aaaattagtt attctcaatt gtccaagatt attgatataa tagaagatgc
     3541 aaagagtaaa ataaaaagca attgcaattt caatataagc atacaagtta tgtctttaaa
     3601 tatatacgag gtgattaaat gataaagata gtaggtataa ggtttaaaag tgctgggaaa
     3661 atatattatt ttgaccctgt tgattttaat atagagcaag atatggatgt agttgtagaa
     3721 actgcaagag gcttggagta tgggaaagta gtcgttggtc caaaagatat ggatgaaagc
     3781 gaattagttt ctcctttgaa gccaattata agaatagcta cagaagaaga taaaaaagta
     3841 tatctagaaa ataaggaaaa ggcaaaagaa acttttgagt tgtgccaaca aaaaataaaa
     3901 gaacatgagt taacaatgtt tttaatagat tgtgagtata catttgatag gaataagttg
     3961 attttttact ttacagcaga aggaagaata gattttagag aattggtaaa agacttagct
     4021 gctatattta aaactagaat agaacttaga caaataggtg tcagagatga agctaaatct
     4081 ataggaggtc tagggccttg tggtagaaaa ctttgttgtt catcttggtt aggtgatttt
     4141 caaccagttt caataaaaat ggcaaaagac caaagtctat ctctaaatcc aacaaaaata
     4201 tctggaatat gtgggagatt attctgttgc ttaaaatatg agcatgatgt atatagtgaa
     4261 gcaatagaaa aaatgcctgt tgtaggtgca ttggtgcaat cagatgatgg aaaaggaaaa
     4321 gttgtagaag tgaatccttt attagaacaa attaaagtgg aatttcaaga caagacagta
     4381 aagatataca caagagaaga tataaaaata cttagagagc ctaaaaaatg tgatggctgt
     4441 ggtggtaaat gtaaggataa tgatggatta gatgaagcca cactaagaga gctaaagaaa
     4501 ttagaagatt aaatttaagg tagggctttt cctacctttt ttaaagcaat taatgcttaa
     4561 agttattaat atttgaggag aatttatata tgcaattaaa agattcagaa agaatagatg
     4621 atttacaatt aaaaggtctt aaaattatac aagatactaa tggtttttgt tttggtatag
     4681 atgcagtttt attagccaat tttactaaaa taaaaaaaga tgccaaagta gtagatttgg
     4741 gtactggaac tggaattata cctattttga tagctggaaa aagtgaagct aaaaaaatta
     4801 ttggcgtgga aatacaagaa gatgtatatg aaatggcaac tcgttctata aaattaaatg
     4861 gattagaaga aagagttgag attataaatg aagatataaa atacatagac aaagtcttag
     4921 acataaatgg ttaccatgta gtcacatcaa atcctccata tatgcatatt gatggaataa
     4981 aaaatccaaa tgataaaaaa gcaatatcaa gacatgaagt aaggtgcaat ttggaagatg
     5041 taattagagc tgcatccaga ttggttatgc ctagaggaaa attcttcatg atacatagac
     5101 caacaagatt ggttgatata ataactttag ggagaaaata taaattagaa ccaaaggtta
     5161 ttcaatttgt gcatccaaga cctcaaaaag caccgaactt agttttggtt caatttgtaa
     5221 aagatggaag gccagagctt aaaatattgg acccattgta tgtttatgga gaagatggga
     5281 attatacaaa agaattaaaa gcaatatata ataataaaga tataggagag ttgtaaatga
     5341 gcgggaaatt gtacatatgt ccaacaccaa taggaaacct agaagatata acatatagaa
     5401 ctttaagaac attaaaagaa gtagacttga ttgcagcaga agatacaaga catagtataa
     5461 aacttttaaa tcattttgaa atctcaaaac cactaactag ttatcatgaa cataataagg
     5521 attcaaaggg agattatttg ataaataaac taattgatgg tgaaaatata gctctgataa
     5581 gtgatgcagg tatgcctggt atatctgacc caggagaaga gataataaaa caagctatac
     5641 aaaataacat agagatagaa gtattgccag gtgcaacagc ctttgtaacg gctttagttg
     5701 gctctggtat ggacacacat agatttgttt ttgagggctt tttagataga gataaaaaag
     5761 ttaggaaagc acaattggaa gaattaaagg aagaaagtag aactataatt ttctatgaat
     5821 caccacatag attgaaggat acactaaaag atatgcttaa aattcttggt aataggaata
     5881 tttctataaa tagagaactt acaaaaaaat atcaagaaat aataagagaa aatatagaaa
     5941 ctaccataaa aatatttgag gaaaaagaag taagaggaga atttgtatta atagtagagg
     6001 gttttcatgg tgagaagtca aagaaagaaa attatgatgg gcttacagat agggaatatg
     6061 ttttaaaact aattgaaagt ggtatgaaca aaaaagatgc aataaaaata gtttgtaaag
     6121 atagaaagtt aaagaaagat gtggtttata aacaagtttt agatttataa aacctgaatc
     6181 tgaggtgatt ttatggaaat agggaaaatt ataatagaga gtttaaagag ggaagataca
     6241 cataaaatat ttatagaatt agataataag catgaattag aaaaaataat tcctaaaata
     6301 agctgtatga agtctgtagg tgaatgtaaa tatcatgtag taaattgttt tgaacattct
     6361 ataaacgcat taaaagaatt agaaatagta ttaaatgata aggatttttt tccaatacat
     6421 ctaagaaaac atgtgtcaaa ctatttaaac acatatattg aagaaggaat aaataagtta
     6481 catgtattaa agctgggaac atttttacat gatataggta agcctgacag tatgacctta
     6541 gatgaaaccg gaagagttca tttcacaaat catgaaaaaa taggtgctca aataattgac
     6601 aatatgggaa taaagttaga gttatcaaca gagacatata gacttataag taaatatgta
     6661 agatatcata tgatactttt gtctctatat aagaaaaatg atttgagtag gaaagaatta
     6721 attaatgtat ttaacttagt agatgaggat actataggtg taataatgct tgggtatgca
     6781 gatatagtgt ctacagtaaa attattgggc aagagtggag aagtcagtgt gttaaagaca
     6841 tatatggaat atattttaac aaattacttg tataagagta attatacaca tgtataaatt
     6901 tagttaatat aattgaattt tagatgatta attgaagttt gaaatatacg gatttcaaaa
     6961 acataaaaga agttgtcttt gttgtaaaat tatgaaagac aacttttttt atatcaaaaa
     7021 ttgaaatttt attaaggata cttaatggtc tattaattaa taaaccatta gtatttaatt
     7081 tatattacaa tattgatttt gcttgtattg gcgttgatag tataacagag gtcttagtag
     7141 aaccaatttt ctttatagta tcaatcacat tttctagctc gtacatatct tttacaatta
     7201 cttttaaaag taagcaatca tcacctgtta tatggtgaca ttctacaatc ctagggtcct
     7261 ttgcagctga ctcaataaat tctgtatatc cattgcttgg aagagaaata tgaataaatg
     7321 cctttataac tctgcctaat gaatctgggt tgacaatagc tttatatcct tctataacac
     7381 cagactcttc taatcttttg actctttctg aaactgcagg agaagttaaa ccaactattt
     7441 ttcctaagtc cttcatagaa attctcccat catcctgtaa aatttctatg attctgtaat
     7501 ctgtaacatc cataaataaa cagtccccct taaataaaaa taattaatgc tataaaactt
     7561 ttttagaatc tatcatttgt gtttttaaat accaaagatt tctagataaa tcaaccttat
     7621 aaatgtgtgg ttttgaaagt cttttgtatt gttcccagat agtacttaat tcatattgta
     7681 catgattttt tatttcaaga acagcttttt tattatattt gcatctgcct tttatataca
     7741 atggtttaag aagctcttta actttgtaat ttgtaaatac cttcgttttc catgtataag
     7801 taggatggaa gatttctaaa ggtttagact catctataac ttcatcatgt aacataatca
     7861 aatctgcctc tgccttattg tcttcgttat atattcttat aactttcttg taaccaggat
     7921 tatttatttt ttctggattc tcagaaatct ttatcttagg ttcaagaact cctttttcac
     7981 aagatgcagc taatttataa actcctccaa gagaaggtga atcgaaagat gtaatgagct
     8041 ttgtacctac tccccatgaa tttatagtag ctccttctgc tttaagtgat gttatggtat
     8101 attcgtctag gtcattagat gcagtgatgc tgatatctga aaagccagca ttatctaatt
     8161 gttttttagc ttctttagat aaataagcta aatctccaga gtcaagtctt atacccatag
     8221 gtttgtatcc tttttcagaa atatttttga atacttttat tgcattagga actccactgt
     8281 ttaatacatc ataagtatct acaagtagta ggcatttatc tggataaaca tcagcatatg
     8341 cttggaatgc ttcaagttca ttatcaaatt tttgtaccca actgtgagct tgtgtaccaa
     8401 ttataggtat atcaaacatt ttccctgcta gtacgtttgc agttccagca caaccaccaa
     8461 ctacagcagc cctagcccca tatatccctg catctggacc ttgtgcacga cgtaatccaa
     8521 attcaaatac agggtctcct tgagctgcaa agcaaactct agaggcttta gtagcaataa
     8581 gagactgaaa attaactatt gttaacaatg ctgtttcaat aagttgagct tgatataaag
     8641 gtgccttaac agtaattaat ggctcattag ggaacatgat agttccttcc tcaacagcat
     8701 atatatctcc tgtgaattta aattctttta aaaattttaa gaacttgtca gaaaataaat
     8761 ttaagttttt taagtactct aaatcttcat ctgaaaaatg aagattatct atgtattcaa
     8821 caacctgatc aataccacaa actatagtat accctccatc acaagcgttt tttctaaaaa
     8881 acatatcaaa tacaacaatg tcttcatgaa tattcttttc aaaatagcca tttaacatag
     8941 taagctgata taaatcagta agaagtgtta gatttctcat tatttctctc cttaattatt
     9001 attaaatatt aaaaattgta aaaactccca cacttatact aaaacataat atagtacaac
     9061 tttcaagtat aaagtattac ctaactatca taaaattatt taaagaggag gatgattata
     9121 ataggaaaaa tatggtttta tatggtatcg ataggaataa taggaagctt gatttctaaa
     9181 aatatgggtg aattaaataa agttatatta agtgaaacat caaaaggtat agagtttgca
     9241 ataagtctag ctggtatcat ggcactctgg atggggataa tgaatatcgc aaaagaatca
     9301 ggtttaattg aaaagatagg tcaaaaacta aatcctataa tgagaagatt atttccttct
     9361 attccaaaag gtcataaagc aatgtcttat atagttatga atattgcttt aaatatgttg
     9421 ggtgctggaa atggtgcaac agcatttggt ttaaaagcaa tgagtgagct tcaaactttg
     9481 aataacaaga aagatacagc cactaatgat atgattatgt ttatggtaat caatatatca
     9541 tctatacaaa taattccatt tactataatc aaactaagga tggatatggg ggctcaaaat
     9601 ccaagtgaaa taatttttac gactttattt gcaaccataa tatctacagc agtagcaata
     9661 ataacatgta aattttttca aagaagatat agataaaggg gatgtagata catggagata
     9721 ttttcaaact tacttatacc aataataatt ctgtacatag tagtttatgg taaatataaa
     9781 aaaatagatg tgtatgatag ttttgtaaaa ggagcaattg atgggttaaa agcagcatgg
     9841 gatatcctac catatataat aggtatattt ttggcaatag gaatattcaa aactggtaaa
     9901 ggtcttgata tgttagaatg gctatttaca ccaatagcaa atatgatgag tataccaaaa
     9961 gaattaatag gtctaataag tgtaaaacct ttatctggaa gtggtgcttt agggatgtac
    10021 agtgaacttg caaatagagt tggaatagga agtttagtag aaaaaatggg tgctacgatt
    10081 gtaggttctt ctgagactat tttttacaca atggcaatat actatggaag tctgaagata
    10141 aaaaatacta gacatacatt atcatgtgct atgattagcc atgttgcagg tgtcatagca
    10201 gctgttttta tttgctatgt aatatttgta taatttgttg acaatatggg aaaaatttta
    10261 taatatagtg attatataga aacaaatagt aatacaaatt acaagctatg aaaagaagag
    10321 taaataaagg ttttttctat cagagagcta ggttaggtga aagctagtgt caaaagcttt
    10381 attgaagatg gtcttggagc tttttatctg agcaagtgtg ctagggtaaa acggttggac
    10441 acgttatagt ctactaaggt atctataaaa tgtttctaca tttcatgtga aacataacta
    10501 ttatagatga attagggtgg taccgtgaat aatctcgccc ctatgttaac tcataggagg
    10561 cgatttttta ttatttaaat gaaagaatca tatgattacg aacgataaaa aattaggagg
    10621 taaataacat gagcaaaccg agtttttatg taacaacacc aatatactat ccaagtggag
    10681 gattacacat aggacatact tattcaacag tagctgcaga tacaatagct agattcaagc
    10741 gtttctgtgg atatgatgta aagttcttaa caggaacaga tgagcatggt gaaaaaattc
    10801 aaaagaaagc catagaacaa ggaatgtcag agatagagta tcttgatgga atgataaaag
    10861 atataaaggc cttatggaat actatggata tatcttatga tgattttata agaactacag
    10921 aaaaaagaca tacagacata atacaaaaga tatttactaa actatatgag caaggtgata
    10981 tatataaagg tgaatatgaa ggtagatact gtactccttg tgagagtttc tggacagaat
    11041 ctcaattact agaaggaaat aaatgccctg actgtggaag agaaacatat ttagtaaaag
    11101 aagaatctta tttctttaga ttatctaaat atgaagacag attaaaagag ttatttaaag
    11161 atgatagttt ctgttttcct gctgctagaa aaaatgaaat ggtggcaaac tttttagaca
    11221 aaggattaga agatttaagc gtaactagaa cgacttttga ctggggtata aaagttcctt
    11281 ttgatgaaaa acatgtaatt tatgtgtggg tagatgcttt atgtaactat ataacagcat
    11341 taggttatat gactgataat gatgaagaat ttaaaaaata ttggcctgcc aatgttcaaa
    11401 tagtaggtaa agaaatagtg agattccata caataatatg gccagcgctt ttaatggctt
    11461 taggtctaga agttccaaaa caagtatttg gacatggatg gatactattt gctgatgata
    11521 aaatgagtaa atcaaaaggt aatgtggttt atccagaacc tataatagaa agatatggaa
    11581 tagacacact taagtacttc ttattaagag agtttgcatt tgggcaagat ggaagttata
    11641 ctcatagaaa ttttgtaacg agaataaatt atgatttagc aaatgattta ggaaacttaa
    11701 taagtagaac tgtagctatg gttgaaaaat acaataatgg tataatacca acagcaaaag
    11761 tttcaactaa ttttgatgct gacttaaaag aacaagctgt ttcaactaga gaaaactttg
    11821 aagctgaaat ggataaaatg caattccatg aagcattaga gagtgtatgg aaattagtta
    11881 gaagaactaa caaatatata gatgaaacta tgccttgggc actagctaaa gatgaaacta
    11941 agaaagatga attagacaca gttttatata atttatgtga atctataaga ataatcgcaa
    12001 cactaataaa tcctataatg aatgagactg ctaataaaat atatgaacat ataggaataa
    12061 aaggtcaaga tgatataact acatgggaaa gtacaaaaac atttggtctt attggagaaa
    12121 atgtaaaagt atttaaaggt gaacctttat tcccaagatt agatgtagaa aaagagatag
    12181 aagaattaac taaaatgttc tctgggaaac ctccagtaga agaaaaacct ttagagcata
    12241 aagaagaaat tactattgat gatttagaca aaatagagct tagagtaggg aaaataataa
    12301 gctgtgaaaa acatccaaaa gcgaataaat tattagtatc acaagttaag attggaccag
    12361 aaacaagaca aatagtatca ggaatagctg aatactataa gccagaggat ttagtaggaa
    12421 aagaggttac agtggtatgt aacttaaaac cagttaaatt aagaggtgta gaatctcaag
    12481 gtatgatatt agcagcaggt gatgatggag acccatatgt tttaccattt acacaagggg
    12541 ctaaagatgg atgtgaggtt cgttagtagg taattaaata gtaaggagat taaagatgtt
    12601 atttgactca catgcacatt taaatgatga aagttttgat gaagatagag atgaacttat
    12661 tggttcatta aaagataaag gtgtagattt ggttgtaaat ccaggagcag atatagagac
    12721 gtcgataaca gcaattgaac ttgcgaaaaa atacgacttt atatattcag cagttggggt
    12781 acatccacat gatgtatcaa aactagatga tacagcaata gaaactctaa gaaaacttgc
    12841 aactgagaat gaaaaagttg tagctattgg agagattgga ttagattatt attatgatta
    12901 ttctccaaga gaagaacaaa aagagtggtt taagaagcaa attgaattag ctaatgagct
    12961 aaaacttcca ataataatac atgatagaga tgcacatgga gatacttttg agataataaa
    13021 gaatactaaa aatcctgaaa taggatgtgt acttcattgt tatagtggga atgtagagtt
    13081 agctagagaa tatgttaaga tgggttgtta tatatcaatt ccaggtacgg ttacttttaa
    13141 gaataataaa aaaactagag aagtagtaag agaaatacct ctagaaagat tattcataga
    13201 gactgattca ccatatatgt caccagagcc acatagagga aagagaaaca atccttctca
    13261 agtatctttt gttgctgata agatagccca ggaaaaaggg atatcttatg aagaagtatg
    13321 tagagttaca aaagaaaatg caaagaaatt ttttaatata aaatagacaa attaaatctt
    13381 ataatgatat atataataag tcattataag tataggatga gagtgcctca aaatgagttt
    13441 tttagtttat gaggcactct ttttgtatga aatcaaatat attttcatca tttcaacaat
    13501 gaaaaagaag tttatcatat tttgagatag tttgttttta tttatttaat tcatatttta
    13561 aaatatattt tcttaacatt gttaaaaaag aatttacaag atattcatta gaattaactc
    13621 aactctaata ttcacttaac ttaagttgtt tattatatta ttaaagagaa gtaaacgaaa
    13681 agtagattaa ggaggttgaa ttttgtatac agttgatagt actaagatat tgataaatat
    13741 gaacttagag aaactagaaa agatatactc aatgataaaa gatacatcaa gtatttctat
    13801 aattaaagaa cctaacttgg ctacagtaat ggtaagagct aatgaaagtg taaaaaacac
    13861 aacatttaat ttaggagaga tattagttac tgaatgtagt gtaaaggtag atgaaagctt
    13921 gggttacgga atagtttcag aaaacaataa taagaaagcc atttatttag cagttataga
    13981 tgcagtttta catagcaata acagtaaatt tgatgagtta aagaattaca taaataaaag
    14041 tgtatatgaa gagaacttaa ggtatgaaca agagattatt gatgaattta gcttgattaa
    14101 taaaacgaaa gttcaattca atgctatgga ttaaatagga ggagaatcat ggtaaattat
    14161 acacaagaaa tatatagaaa gatgctagat agtgcttcat ttcctgggaa attaaataat
    14221 atagataata taaatataga aaataataca aaactattga atggagcaat tggtatagca
    14281 atcactttat tagaccaaga agttaccttc tatatagaaa attatactca aaaagatata
    14341 aaaaatataa gagcacttac aatgtcaaat caaatagatt atagaaaatc agattatata
    14401 tttttagata ttaattcaga agtggatata ttacagatta aaataggttc ttttgaatat
    14461 cctgatgaaa gtgcaactat agtacatcaa gtaaatgatt tatcaacgta ctctcaaact
    14521 aagtatataa agcttgattt gagtggtcct ggtataaaat ctaaaaatag tatatatata
    14581 aatggaatta gagaagaatt tatagaaaga ttatctagca taaataaaga ttatccaata
    14641 ggaatagatt tgattttagt agataaaaaa ggagaaattg catttatacc aaggtcatca
    14701 aaattaagtt gggaggtatt atagaaatgg cttatgtagc agttaaaggt ggagaagaag
    14761 ccatattaca ggctaaaaat atacttgagt tttatagggt aaaaggagat agcttgccta
    14821 tagatgtaaa gcagattgag gaacaaatgt cttatgctgt agacaaagta atgtctgaag
    14881 gaagtttata caacaaggaa ctatcagcat tggctataaa acaagctcaa ggtgatatat
    14941 tagaagcctc tttctatgta agagctttaa ggtcaacaat gcctagaatt acatattcag
    15001 aacccataaa tacagaagaa atgagaataa aaagaagaat atcagctact tttaaagata
    15061 taccaggagg tcagtatctt ggggcaacta gagactatga aaatagaata ttgaatgtag
    15121 aattattaga agaagatgaa aaaaagaata gacattttag agatagtttt ataaatgaat
    15181 tagaaacagt agatgaaatc cctgaattta caaaaatatc taatatattt agaaaagaaa
    15241 atttattaca agaagaagtt tgtgaaaaca aattggaaga agttattgat gatattacaa
    15301 gaaatagttt aagatttcca gtttctaggt cagcaaagtt acaggcatta actagaggtg
    15361 aaagtggagt agtgtcaggt tttgcttatg ctattgtaag aggttttggt gatgaacatc
    15421 catatataag tgaacttaga actggtaatg tatttataaa agtaaaacat cccatctatg
    15481 aagatgaaga aataataata ggggatatgc tggttactga atgtgaaata gtttcaaaag
    15541 catcacaaaa taagactgaa aattctaaaa ctaattcgga agataaaaat aagatgtctt
    15601 taggatatgg tctttgtatg gggaataatg agaataaggc tatatctatg gccatactag
    15661 acaaatcttt ggagccaaat agtgaaaaac tagcacaaga tgaagaattt gtattgcttc
    15721 atatagatgg aatagattca ttaggattta tatctcactt taagcttcct cactatgtag
    15781 attttaaagc ggatgtagaa agaataaaat agtttgagga ggtaagttta ggtgatatat
    15841 aactatggtt ttttagacga aaacacaaaa aaagaaataa gaagaaagat attaaaagca
    15901 atatcaatac ctggttatca agttcccttt ggttcaagag agttgcctat agctaaggga
    15961 tggggtactg gaggtttaca attaacacta tcattaattg gtaaaaatga tgtagtaaaa
    16021 gtaattgacc aaggaagtga tgattctaca aatgcttgta atataaggag ctttattgca
    16081 agtgtaagta atgtagaaac cacaaaagat acattagaag ctacattgat tcaaacgaga
    16141 catagaatac cagaagaaaa acttaaatct aatcaaatac taatatttca agtaccaata
    16201 ccagaaaccc ttagaatagt agaacctagt gaagtagaaa caagaagaat gcattcagaa
    16261 gaagattata gtaggatgtg ggtatatctt tatgaagata tagttagatt taatgatata
    16321 tctatagcag ttgaatatcc atgtaaagta aatgatagat atttaatgaa tccatcacct
    16381 atacctagat ttgatataaa aaaattaaat atgtcagaca atttattctt gtttggtgca
    16441 ggtagagaaa aaagaattta tgctattcct ccatatacaa aggtagaacc tttagagttt
    16501 gaggattata agtttgaaga ggaaaagttt gaaggaaaat actgtagttt atgtaacagt
    16561 acaaatacat ttttagatga agtatatgac agtgacacta atgaaaagta ctatagttgc
    16621 tcagatacaa gttattgtga aaaagttaga ttaaaaaata acagtataga tgtgacaata
    16681 ggaggtactt ggaatgagta aaataaatga ctctaaaaga ttagaaaata tagacaagca
    16741 agtattaata ggaagaaata tcaatcttat ttatggagat gggtgtgaaa agtgttttga
    16801 aagcacagga tatgaaagca ataatatatg taagtattgt ggttctatag ttgcatgtaa
    16861 taatgtaaat ttagaacttt atgaaggaga agtccttgga attgtaggtg aatctggttc
    16921 aggaaaaagc actttattaa aaatactgtt tttccaagaa catgcaaata gtggagaagt
    16981 atatatatcc cattacaata aagacacaaa tatactagag ctttcagacc aaaaaaagag
    17041 atacataaag aatcatttta tgggtattgt gtatcaaaat ccccaccttg gtttaaattt
    17101 agactttagt agtggtggta atatagcaga aaaattattg atggcaaatt tatataatgt
    17161 tgaaaaaata agagatagag gcaaagaact tttaataaaa actaatatac ctgtagaaag
    17221 aatagaccat aaaccaaaat actttagtgg gggaatgcaa caacgagttc aaatagcaaa
    17281 agctctttca aataaccctc caatattgct attagatgag gttacaacag gtttagatgt
    17341 ttctgtgcaa gcggaagtat tggatttaat aagagaaatc caaagagaac ttaagatttc
    17401 tatgatagtt gtatcccatg actttgatgt tataaagatg cttgctgata ggacaattgt
    17461 aatgaaaaat ggaagtgtaa ttgagtctgg tcttacagac caaataatgg aggacccaca
    17521 acacccatat actcagcaac ttataaattc attgctataa atatcgtttg taaataagca
    17581 aaatgggggt ttttaataaa atgaaagaaa ctatacttga agtaaataat tttagtaaag
    17641 actttgagtt acatgcattg aacaagacta taacggcatg tagtaatata agttttgaag
    17701 tttcaaaagg tgagttttta ggaataatag gtaaatctgg agcaggtaag tctaccatat
    17761 taaaaagtat ctataaaaca tatataccaa caactggaga aataattttt aattcagaaa
    17821 tatatggtaa tgtagacctg gctaaaattg gagaccgaga aatgataaat cttagaaaga
    17881 aataggatat gtatcacagt ttttaaagac acttccacga ataactgcaa ttgaactggt
    17941 agtacattct ttaattgaga gtgggtttga aaaagattgt tcgtatgata tggcaaaaga
    18001 tatacttaac caatttgaaa taaaggaaaa tttatgggat gcgtatccaa ataatttttc
    18061 tggtggagaa aaattaagat taaatttagc tcaagctatg gttaaaaagc ctagactttt
    18121 gttacttgat gaaccaactg catcacttga taatcaatct aaaatatatg taaaagaaaa
    18181 aatgttggag cttaaaagtc aaggaactac aatgatagga atttttcatg atatagagtt
    18241 tatggaaact gttatagata agacctttac tatgacaaaa gggactataa gtgaaagtgg
    18301 ggtagcctag atgataaaac taattcataa tgcaaatatt gtattagaag atatgatttt
    18361 agaaaatggt catttaatca tagagggaga tacaataaaa aaagtatcaa atgataagat
    18421 tgattacgca tttgacttta atgagataga tgaaataata gatgcaaaaa acttatatgt
    18481 aatacctggt attatagata ttcacagtga tgccattgaa aaggaaatag agccgagacc
    18541 aagtacatta ttaccattta atatggcatt ttatgaacta gataaaaaac tacctgcaaa
    18601 tggaataact acagtttatc attctatatc tttaggggat ggagtaggag ttagaagtat
    18661 tgataactct ttaaagatga ttaaaaatat tgattcatat aaaaatatag atagtaagag
    18721 cataaatcat aaagttcatt taagatatga agtgttgtat tatgaaggtt tagaaaaggt
    18781 tttagaacta ttagatgaaa ataaaataga ctacttatca ataatggacc attctccagg
    18841 acaaggtcag tatacaaatc caacatttta taaagagtat gctactaaag tgtggggagt
    18901 tacagaaaat tatgtagata catggttaga tgatttagta aatctgcatg ataatttaga
    18961 ttggaataaa atagctaata ttataggtat agccaaaact aaaaatataa atgttgcatc
    19021 acatgatgat gatacattag aaaaaatgga tttcataaaa aatataggca taaatgtatc
    19081 tgaatttcct ataactcttg aagttgcaaa acattcaaag aaattgggtg ttctaacttg
    19141 tttaggtgca ccgaatattg taagaggtaa atctcataat aacaatttaa aagcaatgga
    19201 tgctatattg gaagattgtt gtgacattgt gtgttcggat tatcttccat cagctatgat
    19261 aaagtctatg tgtatagttg cagaaagaat aaataattta aataaagcag tcagtttatt
    19321 tacctcaaat cctgctaaag cagttggtat atatgatgaa agaggtagta taaaagaaaa
    19381 taaaaaagca gatttagttt tagtagatat tgatagtgaa tatccaaagg ttgtaaatac
    19441 tattgtaaat ggaaaaacag tttataaaag ggaggtataa agattgctaa cagagttaca
    19501 ttgtcataca agtatatcag ataataattt tactactgaa gaaataataa aaaaagcagc
    19561 agaaaagaat ataaatatct tagcaataac aaatcatgac acattatctg gattggatga
    19621 agctcttgtg cttggagagc attatggaat aacaataata ccaggtatag aaatttcagc
    19681 ctatgattat aaaaatagaa aaagagttca tattcttgga tataacatag atttaaacag
    19741 tcaagaaata aaaaatttgt gcaatccaat ggtatgtgac agacataaag catctgttaa
    19801 gatggtaaat aaaattatag atttaggata caaaatatct ctggaagatg taaagaaata
    19861 ttcatcaaag actggaatat ttaaacaaca tataatgaaa gctcttatag ataaaggata
    19921 tacagataat atatattcaa atctatataa agaattgttt catagaggaa acggcaaggt
    19981 atatgtatct ttaaaatatg tggattacag agatgcaata aaagctataa aaaattctgg
    20041 tggaatttgt gtgttagctc acccgggtca aatggataat tttagcgcta ttgaagagat
    20101 ggtaaaagta ggattagatg gaatagaagt atatcatcca tctcacaaca aagaactaga
    20161 aaaagagtcg ctttcttatg ctaagaagta taatctagtg gtcacaggag gttcagatta
    20221 ccacggattt tattctcaac ataattatga acttggaagc aagagcttaa ataaagaaga
    20281 tttatttaag tttaggttag ctttaggagg ggtattataa atgtcttttt tacaagtaaa
    20341 aaatgtaggt aaaagttatg gacaagttaa ggtgttaaaa gacatatcta ttgatattga
    20401 aaaaggagag tttatttgtt tactaggtcc aagtggttgt ggaaagagta cactacttag
    20461 aataattgca gggcttgagg ataaacatgg tggaaaaata ataataaatg ataaggatat
    20521 gactaattca ccacctgaaa gtagaaattt tggtatagtt tttcaatcat atgcattatt
    20581 tccaaatatg aatgtttaca aaaacatagc ctttggacta gaaaataaaa acataagtaa
    20641 atctaatatt gataaaaaag ttaaagaagt tctagaagtt gtagaattaa gtggatatga
    20701 gaaaaaatat ccatcacaat tatcaggtgg acaacaacaa agggttgcat tagctcgtgc
    20761 gattgcttta gagccagact ttttacttct tgatgaacct ttatctgcat tagatgcaaa
    20821 agtaagactt aaacttaggg agcagattag aagtttacat agaaaactag gcattacaac
    20881 tataatggta acgcatgacc aagaagaagc tctttgttta gctgataaga tggttgttat
    20941 gaatagagga gaaataatac aagttggaac gccaaaggag gtatataaaa atccagaaac
    21001 accttttgta gctgatttta taggaacaat aaattttata gatgatggta ttaataagat
    21061 agctattaga ccagaagata taaaagtaga gtctaataga gattctaaag ataaggatat
    21121 aaaagtggga gaaattttag atatcgaatt tagaggattt aactatagaa ttacagttga
    21181 gtatcgttct aagcaaatga aattagatgt agtttccaaa gttgcagaac aaatgaaact
    21241 gtgcataggt tctaaaataa actttaagat acctaaagaa ggaattgtac aatataaatc
    21301 agagggatgt gcttaatagc taggggtgaa taaatgataa catcaaaaaa taaaagaaga
    21361 ataagtgata gcacaataca aaaatatttc ttgatttttt cggtaattgt actaatagta
    21421 tttatattat ttccattagt atcattatta aaaaatgcat ttatggatac aagtggaaat
    21481 tttataggaa tttcaaactt tagtaaatat gttgaaaatc caagtcttat agcatcattt
    21541 aaaaattcaa tttttgtatc tacagtctca tctttaatat cactatgttt agcatttata
    21601 tattcatacg caataacaag aacaaacata aagtttaaag aattttttaa aactatggga
    21661 atgtttccac tttttgcacc aactatgtta tatggtattt cacttatata cctttttgga
    21721 aataagggaa tctttacaac catgggtctg gaagtaccac tatatggtcc attaggaata
    21781 attatttctc agattctatt tacatttcca caagcttttt taatattatc tgtagcactt
    21841 tcgatggctg attacagact ttatgaagca gcagatagct tgggtgctag tgaatttaag
    21901 aaattttgca aaataacaat tcctggtata aagtactcat tacttagttc attctttgta
    21961 tcctttatac ttgcatttac agattttgga gcagctaagg tagttggagg aaactacaat
    22021 gtactggcta ctgacatata taaacaagta gttggacaat ttaacatacc aatgggagct
    22081 actgtttcta tggtaatgtt aattcctgta ctaatagcat ttacattaga taagatggca
    22141 agtaagaaac aaggtatgac cataactgca aagtctatgc catataagat taaggaaaat
    22201 aagtttagag atagagtatt tttaatagta tgtagtttta taacattgct aatttttatt
    22261 ttaatattcg tttcagttat aggttcagtt ataaagttat ggccatataa tttaagcttt
    22321 acaatggaac actatacatt taaaggtatt ttgggaagtg gaataaaaac atatttaagc
    22381 agtttgaaaa tatcaacttt aacagcaata tttggaacta tatttgtatt ttttagtgct
    22441 tatatgatag aaaaggtgga taagtttcct aaattaagac aaacagctta ccttttatca
    22501 atgataccaa tggccttacc tggcttagtt ttaggtatat catatataac tttttttaac
    22561 tcagcaagta atccattaaa ttttttatat ggaagtacag caatattagt tatagtaaat
    22621 gtagttcatt tttattcagt ttgttttata acctcaaatt catctttaaa aatgttggat
    22681 aaagagtatg aattagttgc aaaatccata aatattccat tctataaagt attttttaat
    22741 ataacagttc caatgtctat aacatcaata cttgaaatag tagtatatta ttttgtaaat
    22801 tcaatggtta ctgtttcagc attaatattt ttatatacac ctcaaactca gactgcatca
    22861 atatcaatac taaagttaga tgagatagga tatataggac catcagctgc tatggcagta
    22921 ttagtgcttt taacaaatat aatagtaaga cttttgtacg aatttgtaac aaagaaatta
    22981 aaaaataaca cacaaaaatg gcagcaaaaa gatgttgcat aggggaggta aaaatgaaat
    23041 ttaagaagct agtttcttta ggagtattat caacactttt attaagtgta ataacaggat
    23101 gtagtactga ttcatcaggt tcagattcaa agtctgatag taagacaaaa ggggatttaa
    23161 cagtttacac agcaattgaa gaagatagta tagagccata tttagctaca tttaaagaga
    23221 aatatccaga tattaaatta aatattgtta gggcatcaac aggagatata acagcaagat
    23281 tattagcaga aaaggataat cctcaagcag atgttgtatg gggagttgca gccacaagct
    23341 tattggttgc agatgaccag gggatgttag aaccatatgc tccaaaaggt tctgaagaaa
    23401 tagagtctgc atttaaagat gataaagaag ttccttcttg ggttgggata gatgcttgga
    23461 tgacaggtat aacagtaaac actaaagaat taagtgataa gaacatccca gttcctagtt
    23521 cttacgaaga tttaataaag ccagaatata aaggtcttat atctatgcct aatccatctt
    23581 cttctggtac agggtactta acagtatcag cccttataca aattatgggg gaagaaaaag
    23641 catggcagta tatggataag ttacatgaga atattggtgt atacactcaa tctggttcag
    23701 ctccagctac atcagcagct tcaggagaat atcctattgg tatatctttt ggatatagag
    23761 gtataaagtt aaaagaggaa ggctatccag tagaagtagt atttccaaaa gaaggttctg
    23821 gatgggatat agaagcaaat gctcttgtga aaaaagataa tataaaagaa gcatcaaaag
    23881 tatttttaga ttgggctata agtaaagatg caatgaacga atactctaaa aactatgcag
    23941 ttactactat ttctacagga aatccaatac cagaaggatt ccctaaaaag ccattagagc
    24001 aaatgataga taatgattta aaatcagcag caaaaaatag agaagatata ctaaataaat
    24061 ggatatcaaa atatgatggt aagacagaaa aagagagtta agtaaaacta tacaaatgga
    24121 gtaaaaagaa aaattttttt taagtagatt ttattattat aatataagtt gagaataata
    24181 taggtcaaga aaagtgaata ttcta
//
LOCUS       DAEQCW010000055        23443 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.055, whole genome shotgun sequence.
ACCESSION   DAEQCW010000055 DAEQCW010000000
VERSION     DAEQCW010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23443)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23443)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23443
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.055"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(216..1466)
                     /locus_tag="KRO40_002174"
     CDS             complement(216..1466)
                     /locus_tag="KRO40_002174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1015 domain-containing protein"
                     /protein_id="HBH2092991.1"
                     /translation="MATIKPFKAIRPNKYIVDKVAALPYDVMNSKEARRIAEGNPYSF
                     LHIDKSEIDLDENIDLYDEKVYLKARENLDEFRKQEILVKDDKECIYIYKQIMDGRAQ
                     VGIVACISVDESLNGTIKKHEYTRPEKEIDRTKHIKYCDANTGTILVTYKHQRVIDDI
                     INDFMDNNEPLYDFITDDKIEHTVWKIDNDDIIDNLVDKFEKLDYLYIADGHHRTASA
                     ENVAKEMRAKNPNYTGKEEFNYFIAMIAPDENLMVLDYNRVIKDLNGLSEEEFINKIK
                     ENFELEEIEGKEKYKPDKKGTFGMYLGDKWYKMKANKNLLEIEDPVDSLDISILQDYV
                     IDAILGIDNPRVDKRIDFIGGIRGLEELEKRVNEDMKVAFAMYPTSIEDLIRVADANK
                     IMPAKSTWFEPKVRCGLFLHEINE"
     gene            complement(1498..2439)
                     /locus_tag="KRO40_002175"
     CDS             complement(1498..2439)
                     /locus_tag="KRO40_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-3-phosphoglycerate dehydrogenase"
                     /protein_id="HBH2092992.1"
                     /translation="MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDV
                     LVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNIDVKYAQANGIKVMNTPNASSIS
                     VAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
                     AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEIN
                     KMKKGAYLINCARGGLVDEKDLLKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPT
                     PHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL"
     gene            complement(2679..3755)
                     /locus_tag="KRO40_002176"
     CDS             complement(2679..3755)
                     /locus_tag="KRO40_002176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH2092993.1"
                     /translation="MSKKLFIPGPIDVKEEVLQKMATPMIGHRGKDASMLQKSISEKM
                     QKLFYTNNTILLSTSSGTGLMEGSIRSCTSKKAAVFSCGSFGDRWYKMAVANNVPADI
                     FKVELGEATTPEMVDKVLSTGEYDLITVTHNETSTGIRNPIEEIGEVVKKYEDVIYCV
                     DTVSSAGGIKVEVDKIGIDICITSVQKALGLPPGMSICTFSQKAIDRAKQVPFRGVYL
                     DLLAMYEYLIKKNYQYPSTPSLSHMFALDFQLDNILDEGLDNRFNRHEDMANLVRNWA
                     KKHFQIFTNENHLSNTLTVIENTQGISVSNLNSKLQERGFQIANGYGDLKEKTFRISH
                     MGDYTVEDVQELLDNIDDILGFNK"
     gene            complement(4128..4643)
                     /locus_tag="KRO40_002177"
     CDS             complement(4128..4643)
                     /locus_tag="KRO40_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HBH2092994.1"
                     /translation="MDFLAKYKVLKKQNSSKSCLVCGTQNELGLKADFYELENGELVS
                     ICNTKDWHQSYPGRVHGGMSAAILDETIGRAVSINDDQIWGVTVSLELKYKKPVPTDA
                     TIKVVGRITKENRKLFEGTGEIILPNGDIAVTATGKYMKMPIGQIAEGDFSNEEWFFE
                     ESKEKVEYIEL"
     gene            complement(5006..6076)
                     /gene="leuB"
                     /locus_tag="KRO40_002178"
     CDS             complement(5006..6076)
                     /gene="leuB"
                     /locus_tag="KRO40_002178"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HBH2092995.1"
                     /translation="MNCNIAVIKGDGVGPEIIDEGIKVLNKICCKFNHRFDCEYVLAG
                     GCAIDETGEPLPNKTVETCRKNEAVLLGAVGGPKWDKCKGDKRPESGLLKLRESLGLF
                     ANLRPATMYESIKEASPLRTDIVEKGIDFVVVRELTGGIYFGERGRKIIDGIENAYDV
                     EIYNENEIRRIGKRAFEIARNRNKKLISVDKANVLESSRLWRSIMEDLAKEFEDVELS
                     HMYVDNAAMQVVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASLREDSFGMY
                     EPIHGSAPDIAGKDIVNPIATILSVSMMLRHSFNLEEEAKCIEDAVQSVLNKGYRTID
                     IYNGVGNVVGTREMGELIVNEI"
     gene            complement(6083..6574)
                     /gene="leuD"
                     /locus_tag="KRO40_002179"
     CDS             complement(6083..6574)
                     /gene="leuD"
                     /locus_tag="KRO40_002179"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HBH2092996.1"
                     /translation="MIANGSVFKFGDNIDTDVIIPARYLNIADYKELATHCMEDIDDK
                     FISKVKKGDIIVATKNFGCGSSREHAPIVIKESGVSCVIASTFARIFFRNSINIGLPI
                     LECEEAANNIDEGDNIEVDFSTGVIKNITKGKEYKAEPFPEFMQNIILNEGLINSIKA
                     NRG"
     gene            complement(6589..7866)
                     /gene="leuC"
                     /locus_tag="KRO40_002180"
     CDS             complement(6589..7866)
                     /gene="leuC"
                     /locus_tag="KRO40_002180"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="HBH2092997.1"
                     /translation="MGMTMTQKILAKHAKLNEVKKGQLIEADLDVVLGNDITSPVAIR
                     EFEKLGIEDVYDKTKVVMVLDHFTPNKDIKSAEQCKFTRSFAKSKGVVNFFDVGDMGI
                     EHVLLPEKGIVTAGDVIIGADSHTCTYGALGAFSTGVGSTDMGAGMATGKCWFKVPGA
                     IKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMA
                     IEAGAKNGIFPVDDKTMEYINSHKCSTMTKDVNIYEADEDAVYDEVYEIDLAELKETV
                     AFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEVVAEIMKGKKVADGVRVMIF
                     PGTQKVYLEAIEKGYITTFIEAGAAVSTPTCGPCLGGHMGILAAGEKSISTTNRNFVG
                     RMGHVDSEVYLASPAVAAASAITGKISKPSEII"
     gene            complement(7823..9565)
                     /gene="leuA"
                     /locus_tag="KRO40_002181"
     CDS             complement(7823..9565)
                     /gene="leuA"
                     /locus_tag="KRO40_002181"
                     /EC_number="2.3.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HBH2092998.1"
                     /translation="MKCGKYKKYDKMQIVNRKWPDNEIFKAPIWCSVDLRDGNQSLPT
                     PMSVNEKVRMFKMLIDTGFKEIEVGFPSASNTEYTFLRKLIDENMIPDDVTIQVLTQS
                     RAHLIEKTFESIRGCKKAIIHLYNSTSVLQRDVVFNMSKQEIIDIAVEGAKLFNEEVK
                     KYPETEFTFEYSPESFTGTEMDYALEICEAVIDVWKPTPQKKVIINLPSTVEMATPNV
                     YADQIEWFCKNISCRDSIILSLHTHNDRGTCTAASELGLLAGADRLEGTLFGNGERTG
                     NMDIVNVGLNLYTQGIDPELDFSNIDKIIGIYEDCTKLMVHDRHPYAGNLVHCAFSGS
                     HQDAIRKGMIAMKNRDNDYWEVPYLPIDPHDIGREYKEIIRINSQSGKGGAVYIMETD
                     YGFMIPKNMHSDFGNVVKMESDRIGEELSSEAIFNLFKKEYIEVESPYKVKKYKIKSM
                     DELNYENDDSNDTNMIEMTARISYMGNEQRIVGIGNGPVDSFNNALKQCGMKDYKFRY
                     YWEHALEEGSHSRGVAYVGIEHNNEVYFGVSISENINTAAINALMNAINKSYIEEEIK
                     NGDDYDAENISQTC"
     misc_binding    complement(9689..9935)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(10083..10529)
                     /locus_tag="KRO40_002182"
     CDS             complement(10083..10529)
                     /locus_tag="KRO40_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2092999.1"
                     /translation="MSKNKFIYMNYYDNGYFKKGMTIYMVLALIILATIFIYSTTILY
                     ILCIITAVFLFKQGRDFSNKYEGKVYITLDNHSILINNQCIFSIKSKQSQKFNYKIIE
                     KIEVVKNILNIYTDESNYKIRLRALSLEDEKKLLNIIDEKMKKFKA"
     gene            complement(10550..11269)
                     /locus_tag="KRO40_002183"
     CDS             complement(10550..11269)
                     /locus_tag="KRO40_002183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBH2093000.1"
                     /translation="MKKSIMDVHCHTLISGHAHSTFKENVEEASKKNIKYLGISDHGP
                     NMPGGPHPFYFYNLHLLPREVQGVKILRGIEGNIMDYNGNLDVQEDMLKHLDYIIASL
                     HRPCIASGTKEKNTNAILKVMDKPKVKIIGHPDDSRYPLDYEPIVKKAKDKNILLEIN
                     NSSLSSNSHRTGTWENVSHMLTLCKTYGARVILGTDSHICYSIGEFENAEKVLEAVDF
                     PDELVINYHEDEIIEFFDINF"
     gene            complement(11387..12661)
                     /locus_tag="KRO40_002184"
     CDS             complement(11387..12661)
                     /locus_tag="KRO40_002184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HBH2093001.1"
                     /translation="MFIMENDLTMQELLDQQEQVFSKVKVGELTTGKITAVRNDEVQL
                     GLDYGFDGIIPISELNIEKNQYIEDIYHIGDEITAVITKVSQKDGTITLSKLQLDKRN
                     DFAKLQKAYDEHRIITVNVEKNIDKGVFANYNTYTFFIPISQLDTKFITDTSKFVGLN
                     LEVYIKELDVRKNRLVASHRDVLQERINKEREERRAQIKAEKEAERARIKQEREEEKA
                     RIKAAKEDLFNSLEVGQKRDGKVTKIMPYGAFVDIGGIEGLAHINNLAWTRVESVEDV
                     VSEGQEVEVYVLDVNKETKKIALALKDINNDPWDLIAKEVQIDDVVNAKVLRIIEKGA
                     FVQIKEGVDAYLPISELSDTRVAKVTNVVNIGDEVKVKILDFKPKTKRMLVSIKEATR
                     EPEEDITEYLEVEESLGSIGELFKDKFKDLEV"
     gene            complement(12861..14228)
                     /locus_tag="KRO40_002185"
     CDS             complement(12861..14228)
                     /locus_tag="KRO40_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093002.1"
                     /translation="MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGR
                     MENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLAAIKMGEQNNDEAEKIMSNSFSV
                     LVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
                     TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFG
                     KKSILKIKKKYMIPKASIILPVLGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGS
                     MAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKLCLLSCFTYSTILWL
                     LLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLV
                     LALLRKIVLLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKP
                     KAIKE"
     gene            complement(14478..14942)
                     /locus_tag="KRO40_002186"
     CDS             complement(14478..14942)
                     /locus_tag="KRO40_002186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small multi-drug export protein"
                     /protein_id="HBH2093003.1"
                     /translation="MSLRIGGNSLGYLHILILSMVPVTELRGAIPIGIAMGLNPIWVY
                     VFSVIGSTLVSIPLILTFRHVLQFLRGKKLFKGIADVIDRKINSRMKKLKSVSIIGII
                     LFVGIPLPTTGTWTASAIASILKMRIKDAFMGVFLGNLLSGVIVSALSLHII"
     gene            complement(14947..15576)
                     /locus_tag="KRO40_002187"
     CDS             complement(14947..15576)
                     /locus_tag="KRO40_002187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBH2093004.1"
                     /translation="MKKSVLLLDVDYTVINTDSMIDFFIYSLKNKTFKTIIKLPYIIF
                     ILFMYLIRMIPLKKAKEAIFYPIVDFSEEDLKKFFDDCIMKKINESMKKVIYKNKEED
                     NVIIMITASPYAYMKYFKYYGLADEVIGTEFFYENSRYKNQFIGENCKGIEKLKRIKA
                     VLGKLGIEIDYENSYAYSDSKSDLPMLSLTKNAFLVSKKDGEVIEQINS"
     gene            complement(15610..16497)
                     /locus_tag="KRO40_002188"
     CDS             complement(15610..16497)
                     /locus_tag="KRO40_002188"
                     /EC_number="2.4.2.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decaprenyl-phosphate phosphoribosyltransferase"
                     /protein_id="HBH2093005.1"
                     /translation="MKQTNTSIRLLTKISDYIKLMRIKQYIKNFFVFSAIIFSNNILN
                     INLFLNTFIAFVCFCLMSSSVYALNDAIDMDKDKKHPKKCNRPVASGRISKKSANILF
                     VVLALISVCLSTVVSFNLSIILSLYLINNILYSLKLKNIILLDVFSISLGFILRVYAG
                     CVAISVSLSNWIILCTFFLSLYLALGKRKKEIETLRDDAVEHRKILEDYDIENLNQMM
                     IVILSSTIVCYALYSTSNPEKPHMIFTTIFVVYGVLRYNYIINTTNENNPTDIVLKDN
                     ALKINVILWIITCLIILIF"
     gene            complement(16526..17764)
                     /locus_tag="KRO40_002189"
     CDS             complement(16526..17764)
                     /locus_tag="KRO40_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093006.1"
                     /translation="MDGDILMSKILKYKNEMFLFILVVITYLIITKIFFSKTTIFYDL
                     NNTYDVLLDTDTGVLFNLNVFAISQDNSKHILFSAIISIFAYPIYLFCTSIANPGTTD
                     FNSAYGFGLICLQIITSAMSITLVFNHIKKIKMQRLTLILLTMIMIFSFPQLFMTLNV
                     ERFIYSQFSLIFFIVIANKMKGKNSYLVELAAIPLFGITISNIYLYFFNMIFEFKLKI
                     GKMLKHLITFILMAYICVVSTKSYESFMNLGNVIQYDTKFISGEPILEKIAMIIERLL
                     YSVFYFPGASIKKGLFLQNGEVATIPVILTLLALCFCVLSVIENSEKRVPKLCMGIII
                     FNLTLHGIVGYNLVNSSIMAINFSFAVIILLAYFTKALRKNEKNMYNIFLSLLLVTIV
                     ISNVNGFIEILNIGIKSYPV"
     gene            complement(18148..19290)
                     /locus_tag="KRO40_002190"
     CDS             complement(18148..19290)
                     /locus_tag="KRO40_002190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH2093007.1"
                     /translation="MRYVEYGKTGKMVSVVGYGGLRFDLEKSNQENADLVKYAYEKGI
                     NYFDTAPGYCDDRSEDIFGLAFRQMIKEGKTDFYVSTKEKPKACDTSEKAIEAVKKSI
                     ERLGVSKINFYHVWNIRKMEHYELAMRPGGQYEGLLKCKEEGLIDHIVFSSHQPGDEV
                     IDILSENKFEGVTMGINILNFPYRLKGAKYAVDNGYGVVAMNPLSGGTIPKYNKELSF
                     LSKDGESTIESALRFNIGISQISISLIGFNKKQDIDDACKIADENRIYSDEDIHDIET
                     RLNKNMNEICTGCGYCKVCPKGINTPAYMLFYNEKQMFKKSDEEMTKLVYGLGHWNYT
                     MNSKAKAKECISCGKCEVECTQHLPIIDRLKEIKKWEEDGANSVKV"
     gene            complement(19431..20297)
                     /locus_tag="KRO40_002191"
     CDS             complement(19431..20297)
                     /locus_tag="KRO40_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH2093008.1"
                     /translation="MDNYKKVKQVLWIILFANFAVALLKIIIGNQIKSYSMTADGFHS
                     LSDGASNIVGLIGIFFASKPKDKNHPYGHKKFEIITSLFISGMLFVIAIKIILSAVLR
                     IANPVVPAITIESLIALIITLFINIFVCMYEYRIGTKLNSYVLISDSLHTRSDIFVSL
                     GVLVTLVGVKLGFPVIIESIVPIIISAFIIYSAYGIFRPSIGILVDRVAVDEDYIKEI
                     VFEFNEVRDVHNIRSRGSKSSIYIDMHVMVDPFISVEQSHDLTHKIEKQIQEEINENA
                     QVIVHIEPFYSF"
     gene            complement(20631..22178)
                     /locus_tag="KRO40_002192"
     CDS             complement(20631..22178)
                     /locus_tag="KRO40_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH2093009.1"
                     /translation="MANFFNFILLQKDKIIELLIQHMSLTVTSILIAIIVGVPLGIII
                     SRISSLRKFVLGFVNLVQAVPSMALLGLLVPILGIGSKPAIFMVVVYSLLPIVKNTYI
                     GITSIDPVVLESAKGIGLTRNQTLFKIQFPLALPIIMGGVRISAVTAVGLMTLAAFIG
                     AGGLGYLVFSGVQTVNNNMILAGAIPSCIIALLVDYLFSKIEVAVTPKGLNPKAPKKN
                     YIALKVISVVVVVSMLFVVFSSSFSSKKDTITIGSKDYTEQLILGNVYAELVEKNTNL
                     KVKKNLNLGGSSVAFNAIKSGELDMYVDYTGTLLVNVMKHAPIKDADEAYNVVKDTME
                     KENQLTLLDPLGFNNTYTLAMMPETAEKYGINTISDLTKYGKEFTFSPTLEFENREDG
                     LVGLSRDYGLKFKDVKAMNGSLRYTALDNNESQVIDAFLTDGLIKKFNLKILEDDKNF
                     FVPYYAAPLVREDTLKKYPELEKVMNMLSGKINEETMRELNYQVDELGKSPEEVAHSF
                     LVKEGLV"
     gene            complement(22171..23307)
                     /locus_tag="KRO40_002193"
     CDS             complement(22171..23307)
                     /locus_tag="KRO40_002193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093010.1"
                     /translation="MIEIRNVTKKIGNNVILDDISLVVETGTLVVLIGSSGCGKTTTL
                     KLINKLIKPTSGEIYINGKPISQENEIELRRKIGYVIQNTGLFPHLTIKENIELIPRL
                     KKEKSVEEIEKRTLQLLEMVGLDSDEFLNKYPSELSGGQQQRIGVARAIATDAEIILM
                     DEPFSALDPITRTSLQEQLFSLQDELKKTIIFVTHDMDEALKIADKICIMKDGRIAQY
                     DTPENILRKPANDFVKDFIGEDRVWDNPEYIKARDIMIKNPIAVNSTRTVTQGIEIMR
                     TSKVDSLLIIDRAKTLKGIVTVKDMKDIDDKSILLADIMSSEPLHVNEGDNLVEILNV
                     MNRNSVGYIPVISDENKLVGLITRSSLLSVLSEQFLEMEVSVLG"
BASE COUNT         7621 a         4265 c         2436 g         9121 t
ORIGIN      
        1 taaaacctta taaatataca aatacaatta tatgaatttt catcctcaat tatagcatag
       61 aatatgacta tctatatcct aaaattatcc atttctaaaa aaaaggtaac tattattaag
      121 aatatcaact tatagaattt atattccaca tacgattttc aatcaaaaaa acaagggcta
      181 aaaagtgaat tgtgcacttt ttagcccttt attaattatt catttatttc atgtaagaat
      241 agaccacatc ttactttagg ttcaaaccat gttgacttag ctggcattat cttatttgca
      301 tctgctactc ttattaaatc ttcaatacta gtaggataca ttgcaaatgc tactttcata
      361 tcttcattaa ctcttttttc taattcttca agacctctaa ttccaccgat aaaatcaatt
      421 cttttatcta ctctaggatt atcaattcct aaaatagcat caataacata gtcttgtaat
      481 atagaaatgt ctaatgagtc aacagggtct tctatttcta ataaattttt atttgctttc
      541 attttatacc acttatcacc taggtacatt ccgaaagttc cttttttgtc aggtttatat
      601 ttttcttttc cttctatttc ttctagttca aaattttctt ttattttatt tataaattct
      661 tcctcgctta aaccatttaa gtctttgata accctattat aatccaaaac cattaaattc
      721 tcatctggtg caatcattgc tatgaagtaa ttaaattctt cttttccagt ataatttgga
      781 tttttagctc tcatttcttt ggctacattt tctgctgaag ctgtcctatg atgaccatct
      841 gcaatgtata gataatctaa tttttcaaat ttatctacta ggttatctat tatatcatca
      901 ttatcaatct tccatactgt atgctctatc ttgtcatctg ttatgaaatc atataaaggt
      961 tcattattat ccataaaatc attgattata tcatctatca ccctttgatg tttgtaagtt
     1021 acaagtatag ttcccgtatt agcatcacag tattttatgt gtttagttct atcaatttcc
     1081 ttttctggtc gagtgtactc atgttttttt attgttccat tcaagctttc atcaactgat
     1141 atacatgcta ctataccaac ttgagctcta ccatccatga tttgtttata tatatatata
     1201 cactctttgt catcttttac tagaatttct tgttttcgaa actcatctaa attttctcgc
     1261 gcttttaaat aaactttttc atcatataaa tctatatttt catctaaatc aatttctgat
     1321 ttatctatat gcaaaaatga atatggattc ccttctgcaa ttcttctagc ttctttacta
     1381 ttcataacat cgtaaggaag tgctgctact ttatctacta tatatttatt tggtctaatc
     1441 gccttaaatg gtttaatcgt tgccattact aatttcctcc taattataca aaatatttta
     1501 taatgctacc cctattagat tgttgaagtc aagaaagaaa tcttgaatca catttactat
     1561 ttcgtctcct attctttctt gagcttctac tgtagatgcc ccaatatgag gtgtaggaga
     1621 aactcttgga tgatttacta agtctaaatt taatgtaggt tcttgttcat aaacatctat
     1681 agcagctgct gataatttac cttcatctaa tgcttttagt aaatcttttt catcaactaa
     1741 accgcctctt gcacagttta ttaaataagc ccctttcttc atcttattta tttctttttc
     1801 agttattact gcccccttat tcttatcaaa tggtatgtgt aaagataaga aatctgcatt
     1861 ttctaaaact tcttccatat cacagaattt ataattgtta aagccttgcg cctcacccat
     1921 tatgtcagta tatataacat tcatacctaa taattctgct ctctttgcaa cttcttttgc
     1981 aattcttcca aaacctataa gtccaagtgt ctttccatta atttctgtac ctttatactt
     2041 tttcttctcc cattttccat ctctcatagt tacatttgca gtatttatga atcttgcaag
     2101 aacaaataat tgacctattg taagctctgc aacagatata ctgcttgcat ttggagtatt
     2161 cataactttt atgccattag cttgagcata tttaacatct atattatcca gacctactcc
     2221 acctcttact atcaacttca actttttacc ctctaatgct ttatctatta catctttagt
     2281 aactttagta gctgaacgta ctacaagtac atcaacatct ttaagtttat ctcctaaaac
     2341 atctttttca taaaactgct ctatcacatt aaaatctaac tctctcaatt ttctcgctgc
     2401 ttctttctct attccatcag taactaatat attatacata acaaactcct ccaattttta
     2461 ttcacttaat ttttccaatt tttatttttt aaagtatttt catcaataaa aaactttact
     2521 taattcaact ttctgtttat ataattttca aaatattttt ttattaaagt catgtcaaat
     2581 ttttctattg tttgttaaaa atttaatatg taatttttat aaaatattat ttattatata
     2641 ttctaaattt atcttaaaac atacatattt ttacaatatt atttattaaa acctaatata
     2701 tcatcaatat tatctaataa ttcttgtaca tcttcgacag tatagtcacc catatgtgaa
     2761 attctaaaag ttttttcttt taaatctcca tagccatttg ctatttggaa tcctcgttct
     2821 tgtaattttg aatttaaatt tgatacacta ataccttgag tattttctat aacagtaagt
     2881 gtattggata agtgattttc attggtaaaa atttggaagt gttttttagc ccagtttcta
     2941 actaagtttg ccatgtcttc atgtctgttg aatctgttat ctaggccttc atctaatata
     3001 ttatctaatt ggaaatctaa agcgaacatg tgagaaagag atggtgttga agggtattgg
     3061 tagtttttct tgattaagta ttcatacatt gctaacaaat caagatatac tcctctaaaa
     3121 ggtacttgct tagctctatc gattgctttt tgagaaaatg tgcaaataga cattcctggt
     3181 ggtaatccca gtgctttttg tactgatgtt atacaaatat ctattccaat cttatcaacc
     3241 tcgactttta ttccaccggc tgaacttaca gtatctacac agtagattac atcttcatac
     3301 tttttaacaa cttctccaat ttcttctatt ggatttctta ttccagttga agtttcattg
     3361 tgagttacag ttattaaatc gtattctccg gtagaaagca ccttatcaac catttctggc
     3421 gttgttgcct ctcctaattc aactttaaat atatccgctg ggacattatt agccactgcc
     3481 attttgtacc atctatcacc aaaggatcca caggaaaata ctgctgcctt tttggatgta
     3541 caggaacgaa tggagccttc cattaaacca gttccggatg acgtggataa aagtatcgtg
     3601 ttgtttgtat agaatagttt ttgcatcttt tcacttatac tcttttggag catagatgca
     3661 tcttttcctc tatgtcctat cattggtgta gccatctttt gcaagacttc ttctttaaca
     3721 tcaataggac caggaataaa taatttctta ctcattataa ttcccccctt tttagtttgt
     3781 aatatggata gcgtttttac tgtccttatt tttaataact ataatatcaa gctgaattaa
     3841 ctatgtcaac ataaaattta ttttttatat ataatttatt ttatatattt tatgaaaaca
     3901 ttcattttct accttttcat aagtctgaat tttctgaatt attctctcaa aaaaaatata
     3961 ctttttatct atataaatta atttttttag tatgtaaatt tgacgctatt acgataaatc
     4021 tttttagtat aactaattta tttttatctt gtatttttat tgtatttttg aattttattt
     4081 tttctaaata taaaatttat gttttaaaat gtaaaatttt tatttaatca aagttcaata
     4141 tattccactt tttctttcga ttcttcaaaa aaccattctt cattagaaaa atcaccttct
     4201 gcaatttgtc caataggcat tttcatatac tttccagttg ctgtcactgc tatatctcca
     4261 tttggtagaa ttatttctcc tgtaccttca aataattttc tgttttcttt agttattctt
     4321 ccaacaactt ttatagtagc atctgttggt actggtttct tatatttcaa ctctaaagat
     4381 actgttactc cccatatttg gtcatcattt atacttacag ctcttccaat agtctcatcc
     4441 aatattgcag cagacatacc tccatgaact ctcccaggat aactttgatg ccaatccttt
     4501 gtattacaaa ttgatacaag ctctccattt tcaagttcat aaaaatctgc tttaagtcct
     4561 agctcatttt gtgttccaca aactaaacaa gatttactac tattttgctt cttcaaaact
     4621 ttatactttg ccaaaaaatc catctcctaa ccgacattag tagtcgctta atattaaata
     4681 attctaaaat atattatata atattaataa aatccctgca aacttctaat aataaaaata
     4741 ggctacttca atatgataag tttaatttaa agtattattt tccaaaaaat aactttatca
     4801 aaatagaaac tcaaagtaga tataagcctc tttttcgtta ttaaaatagt aaaaatatat
     4861 tttacttaat ataaaaaaga gtgtctcatt aactaataaa gtttattttg agacacccct
     4921 cataaaacaa attatactac aatagatttt tactaattct acaagttata tattcaaatt
     4981 atattattca aattaaacta taattctaaa tttcatttac tattaattcg cccatttccc
     5041 ttgttcctac aacatttccc acaccattat agatatcaat agttctataa cctttattga
     5101 gtacactttg tacagcatct tcaatacact tagcttcttc ttctaagtta aaactatgtc
     5161 ttaacatcat gcttacagat agaatagtcg caattggatt tacaatatct tttccagcta
     5221 tatcaggtgc acttccatgt attggttcat acataccaaa actatcttct ctaagtgatg
     5281 ctgatggtaa catacctata gaacccgtaa tcatagatgc ttcatcagat attatatctc
     5341 caaatatatt attagtcact attacatcaa attggctagg gtcttttaca acttgcatag
     5401 cagcattatc aacatacata tgtgacagtt ctacatcttc aaactcttta gctaagtctt
     5461 ccattatact tctccaaagt cttgaactct caagcacatt tgccttatct acacttataa
     5521 gttttttatt tctatttctg gctatttcaa aagctctctt accaattctt cttatttcat
     5581 tttcgttata tatttctaca tcataagcat tttcgatacc atcaatgatt tttcttccac
     5641 gttctccaaa ataaatgccc cctgttaatt cccttacaac aacaaaatca atgcctttct
     5701 caactatatc cgttctaagt ggtgaagctt cttttatact ttcatacatt gtagctggtc
     5761 ttaaatttgc aaataaaccc aatgactctc ttaattttaa aagaccagac tctggtcttt
     5821 tatctccctt acatttatcc cactttggtc ctccaacagc accaagcaat acagcttcgt
     5881 tttttcgaca agtttcaaca gttttattag gtagaggttc tccagtttca tcaatcgcgc
     5941 atcctccagc taatacatat tcacaatcga atctatgatt aaatttacaa caaattttat
     6001 ttagaacctt tataccttca tctataattt ccggtccaac accatcacct tttatgactg
     6061 ctatattaca attcatactt cactaccccc tatttgcttt tattgagtta attaagcctt
     6121 catttaatat aatattttgc ataaactcag gaaatggttc tgctttatat tcttttcctt
     6181 ttgttatatt ttttatcaca cctgtagaaa aatctacttc tatattatcc ccttcatcta
     6241 tgttattggc agcttcttca cattcaagta taggaagccc tatatttata gagtttctaa
     6301 aaaatattct agcaaaagta gaagcaatca cacaggatac tccactttct tttattacaa
     6361 ttggtgcatg ttctcttgat gaaccacaac caaagttttt agttgcaact ataatatctc
     6421 ctttttttac cttagaaata aatttatcat caatatcctc catacaatgc gttgctagtt
     6481 ctttataatc agctatattt aaatatctag ctggtattat tacatctgta tctatattgt
     6541 caccgaattt aaaaacactt ccattggcaa tcataaattt tacctccctt aaattatttc
     6601 tgatggtttt gatatttttc cagttatagc tgatgctgct gctacagctg ggcttgcaag
     6661 atacacctct gaatcaacat gccccattct tcctacgaaa ttcctatttg ttgttgaaat
     6721 ggatttttct cctgctgcaa gtatacccat atgtccccct agacatggac cacaagttgg
     6781 tgtagaaact gctgctcctg cctctataaa agtggtaata tacccttttt ctatagcttc
     6841 aagatatact ttttgagttc caggaaatat cataactcta actccatctg ctactttttt
     6901 gcctttcatt atctcagcta ctacttcaag gtctgatatt cttccatttg tacaagagcc
     6961 tattacaact tggtctatct ttatatcctt atctatctca tctactgttc tagtattttc
     7021 aggaagatga ggaaaggcta ctgtttcttt tagttcagct aaatctattt cgtatacttc
     7081 atcatagact gcatcttcat ctgcttcata tatatttaca tcttttgtca tagttgaaca
     7141 cttatgtgaa tttatatatt ccatagtctt atcgtctact ggaaaaattc cattttttgc
     7201 tcctgcttct attgccatat tacaaatagt aaatctatca tccatagata agtattctac
     7261 tccatctcca caaaattcca ttgacttgta aagtgctcca tcaacaccta tctcccctat
     7321 tatatgaagt attatatctt taccacttat ccatttattt ggtttattct tcaaaacaaa
     7381 ttttattgct ccaggaacct taaaccaaca ttttcctgta gccatacctg ctcccatatc
     7441 agttgaacct acaccagtag aaaatgctcc taatgctcca tatgtgcaag tatgagagtc
     7501 agcacctata attacatctc cagcagttac tatacctttt tcaggaagaa gaacatgctc
     7561 tattcccata tctcctacat caaaaaaatt tacaactcct tttgattttg cgaaacttct
     7621 tgtaaattta cattgttctg cactctttat atctttatta ggtgtaaagt ggtctaaaac
     7681 catcactact ttagtcttat cataaacatc ttcaattcct aatttttcaa attctctaat
     7741 ggctactggt gatgttatat cattacctaa aactacatct aaatctgctt cgattaattg
     7801 ccctttctta acttcattta atttagcatg tttggctaat attttctgcg tcatagtcat
     7861 ccccattttt tatttcctcc tcaatataac ttttatttat tgcattcata agtgcattaa
     7921 tagctgctgt atttatgttt tccgatatac ttacaccaaa atagacttca ttattgtgct
     7981 ctattcctac ataagctacc cctcttgaat gtgacccttc ctctaatgca tgttcccagt
     8041 aatatctaaa tttataatct ttcatgccac attgctttag tgcattatta aatgaatcta
     8101 caggtccatt tcctatacca acaatccttt gttcatttcc catataactt attcttgcag
     8161 tcatctcaat catgttagta tcattagaat catcattttc atagtttaat tcatccattg
     8221 attttatttt atacttctta actttataag ggctctcaac ttcaatatat tctttcttaa
     8281 acaaattaaa tattgcttca ctactaagtt cttccccaat tctatcagat tccattttga
     8341 ctacatttcc aaaatcagaa tgcatattct taggtatcat aaatccataa tctgtttcca
     8401 ttatataaac agctcctcct tttccagatt ggctatttat ccttataatt tctttgtatt
     8461 ctcttccaat atcatgaggg tctattggta aatatggaac ttcccagtaa tcattatctc
     8521 tgtttttcat tgctatcatg ccttttctaa tagcatcttg atgtgaacct gaaaaagcac
     8581 aatgtacaag attacctgca tatggatgtc tatcatgtac cataagtttt gtacagtctt
     8641 catatatacc tattatctta tctatattgc taaaatctag ctctgggtct attccttgtg
     8701 tataaagatt aagtcccaca tttactatat ccatattccc agttctttca ccatttccaa
     8761 atagtgttcc ttcaagtcta tcggcaccag ccaataatcc aagttcactt gcagccgtac
     8821 aagttcctct atcattgtga gtatgcaaac ttagtataat agaatcccta caacttatat
     8881 ttttacaaaa ccattctatt tggtctgcat atacgtttgg tgttgccatt tcaactgttg
     8941 atggaagatt tattattact tttttttgag gagttggttt ccaaacatct atcactgcct
     9001 cacatatttc aagtgcataa tccatctctg ttcctgtaaa actctctggt gaatattcaa
     9061 aagtaaattc tgtttctgga tattttttta cttcttcatt aaataatttt gctccttcaa
     9121 ctgctatatc tattatttct tgtttactca tattaaaaac cacatctctt tgaagaacag
     9181 atgtagagtt atataaatgt ataattgctt ttttacatcc ccttattgat tcaaatgttt
     9241 tttctataag atgagcccta gattgtgtaa gtacttgtat agttacatca tctggaatca
     9301 tattctcatc tattaatttt cttaaaaatg tatactctgt atttgatgct gatggaaatc
     9361 ctacctctat ttctttaaat cctgtatcaa taagcatttt gaacattctg actttttcat
     9421 ttacactcat aggtgttggc agtgactgat ttccgtctct taaatcgaca ctacaccaaa
     9481 ttggagcctt aaatatttca ttatctggcc atttacgatt tactatttgc attttatcat
     9541 attttttata ctttccacac ttcatgttat ttcccccttt ttttgttttt tgtattcagt
     9601 atacctcata tcgacgcaat cctgcacaat tcataaggat aaatgtcaat tttatcatta
     9661 gaataaaaaa aacctcatct ctaataaaat tagagacgag gttttgctcg cggtaccact
     9721 ctatttagct ttctaaaaag ctcccttagt aatagccaat acaataatta taatgactat
     9781 atttcctata acgtggaatt actccgatta ttctaagatt taaatcttag aaaacagctc
     9841 ctagacaagt tcagaactat caactactaa atcacaccat cctttagctc tctgaaagtt
     9901 tcattgttct tactacttct attcatcact tttttaatca tttaaatttt ctaaatattt
     9961 tgatttaata gttattatat acacattaaa atgtattgtc aacacaaaaa ataattatct
    10021 caatttttta tttttgataa gcaattctat aaaacatgct aactattgaa aacagtatga
    10081 tattatgcct taaacttttt catcttttca tctatgatat tcaataattt tttttcatct
    10141 tccaaactca atgcccttaa tctaatttta taattagatt cgtcagtgta tatatttaat
    10201 atatttttta ctacttctat tttttctatt atcttataat taaacttttg actttgttta
    10261 gattttatac tgaatataca ttgattattt attaatattg aatgattatc gagagtaata
    10321 tatacttttc cctcatattt atttgaaaaa tcacgacctt gtttaaatag aaaaactgct
    10381 gttattatac ataaaatata taatattgtc gttgaatata taaaaattgt agctaaaatt
    10441 ataagtgcta aaaccatata tatagtcatt ccttttttaa aataaccatt gtcataataa
    10501 ttcatataga taaacttatt tttactcaaa ttttttcact cccaagattc taaaaattta
    10561 tatcaaaaaa ttctataatt tcatcttcat gataatttat gactaattca tctggaaaat
    10621 ctactgcttc taaaactttt tctgcatttt caaattctcc tatagaataa catatatgag
    10681 agtcagtacc aagaattact cttgcaccat atgttttaca caatgtcaac atatgactta
    10741 cattttccca agtacccgtt ctatgagagt ttgaacttaa tgatgaatta tttatttcta
    10801 aaaggatatt tttatcttta gcttttttta ctataggttc ataatctaaa ggatacctac
    10861 tgtcatctgg atgtccaatt atttttacct taggtttatc cataactttt aaaatagcat
    10921 ttgtattttt ttcttttgta ccagaggcta tacaaggtct atgcaaactt gcgattatat
    10981 aatccaaatg tttcaacata tcttcttgaa catctaaatt accattataa tccattatat
    11041 ttccttctat tcctctaaga atctttacgc cttgcacttc acgtggaagc aaatgcaaat
    11101 tataaaaata gaatggatgt ggtcctcctg gcatattagg tccatggtct gatattccta
    11161 agtattttat attcttctta ctcgcctctt cgacattttc cttgaaagta ctatgtgcat
    11221 gtccacttat tagagtgtga caatgtacat ccataataga ctttttcatt aaatttcctc
    11281 ctaatatttt acataaattc gtgaaaatag ctaaagggct atttcaaaac taaagctgtc
    11341 ataatagaca gtgtaacgtt ttaaaacagc cccattttca attattttac acttctaaat
    11401 ctttaaattt atctttaaat aattctccaa tacttcctaa agattcctct acttctaggt
    11461 attctgttat atcctcttct ggctctctag ttgcttcttt tattgaaacc aacattcttt
    11521 tagtctttgg tttaaaatca agaatcttaa ctttaacctc atctccaata ttaacaacat
    11581 tagtaacttt agccactcta gtatcactca attcagatat tggtaaatac gcatctacac
    11641 cttctttaat ttgaacaaaa gccccttttt ctattattct aagaacttta gcattgacaa
    11701 catcatcaat ttgtacttct tttgctatta aatcccaagg gtcattattt atgtctttta
    11761 atgccaaggc aattttttta gtctctttat ttacatccaa cacataaact tctacttctt
    11821 gtccctctga aacaacatct tcaacacttt caactcttgt ccaagctaaa ttatttatat
    11881 gtgctaatcc ttcaatccca ccaatatcca caaatgcacc ataaggcatt atctttgtca
    11941 ccttaccatc tcttttttgt ccaacttcaa gagaattaaa taagtcttct ttagctgctt
    12001 tgatacgagc tttttcttct tctctttctt gcttaattct tgctctttca gcttcttttt
    12061 ctgccttaat ttgagctctt ctttcttctc tctctttatt tatacgctct tgtaatacat
    12121 ctctatgaga tgctacaagt ctattttttc taacatccaa ttcttttata taaacttcta
    12181 agttaagacc aacaaattta gatgtatctg taataaattt tgtatcaagt tgagaaattg
    12241 gtataaaaaa tgtatatgta ttgtaattag caaatacacc tttatctata ttcttttcaa
    12301 catttacagt tattattcta tgttcatcat aagccttttg taacttggca aaatcatttc
    12361 ttttgtcaag ttgtaattta gataaagtta ttgtaccatc tttttgagat acttttgtta
    12421 ttacagcagt tatttcatca cctatgtggt atatatcttc tatatattga tttttttcta
    12481 tgttcaattc acttataggt attattccat caaacccata gtctaatcct aattgtactt
    12541 catcatttct cactgcagtt atttttccag ttgtcaattc tccaactttc actttgctga
    12601 atacttgttc ttgctggtca agtaattctt gcattgttaa atcattttcc attataaaca
    12661 tcctttcctc ttattgatta tcatatctgt aaatattata ccattaatat tgcaaatact
    12721 tacatttttc ttactataat ttttaaaata aattcaactt catatattta tacattatag
    12781 aaaatatctt attaaattaa aatacaaatt ctaattttta tctaataaaa tattttcata
    12841 aaaaatttat attgtatatc ttattctttt attgctttag gttttgatag aaaacattta
    12901 taaaatataa agaaagaaat tgctgttata gtagcagctg ttatatctgc aactggctct
    12961 gctaaaatta ctgcaaaaag tttttcatta aagaatgttg ggagtataaa tattaaaggt
    13021 attaaaagta caatctttct aagtagagct aaaaccaaag atattgttgc ttttccaagt
    13081 gctaaaaatg tctgttgaca agctatttga atcccaaaca taaaagcacc agcaaaatat
    13141 atttttatac tccaactagt catactaagt aactgcggat tcttattaaa tatactaaca
    13201 aaaaatgcag gaaatatcat taataaaagc cataaaatag tagaatatgt aaaacatgac
    13261 aacaaacaca acttaaatgt cttttttact ctatcaagtt gacctgaacc ataattataa
    13321 cttattattg gttgtgctcc ttgtgtaacc cccatattag gaagcataag aatttgcatt
    13381 atactgctca ttatggccat tgaacctact gctaaatctc ctccatacat ttgtaattta
    13441 ctatttaagg ctataagtac taaactttct gtagattgca ttataaatgg agagattccc
    13501 aaaccaagca ctggtaagat gatacttgct tttggtatca tatacttctt ttttatttta
    13561 agtatacttt tctttccaaa gagaaacata agtacccaaa tagcagaaac gccttgtgca
    13621 attatagtag ctaatgcagc tccttttaca cccatattaa agccaaatat aaaaatcggg
    13681 tcaagtatta tgtttattaa agcacctata gcaactgtca tcattccagt tgtagcaaac
    13741 ccttgggtat ttataaaagt attcataccc attgaaatct gaacaaacac tgtacctatt
    13801 aaataaatat ttaaatagtc cattgaatat ccaattgtag attcacttgc tccaaacatc
    13861 caaagtaaag gctcttttcc aatcttaaaa cctatagtca aaagtattgc taaaatcacc
    13921 agtacagaaa aactgttact cattattttc tctgcctcat cattgttttg ctcacccatt
    13981 tttatagcag ctaatggacc tcctcccata ccgattaaat aactacatgc agttattata
    14041 attattattg gaaatgccac tccaacacca gccatagcaa cttctccatt ttccattcta
    14101 ccaataaaaa tcctatcgac tatgttgtat aaaacattta caatttgtgc gataatagca
    14161 ggtgtagcaa gtttaaataa taatttaccc acactttcac tacctaagtt agtgtttgaa
    14221 ttttccattt taaaacctcc tcaatccaat aattaaaatg tatcactaaa attttattct
    14281 atataaaaat ttcattttat tagcagacaa atttagagta ctttccctac aagtaatact
    14341 atactatatt tcttttgcca tagtaaacat tttagaacta actgaagtta aatactttat
    14401 ctcatttttt atttattatt aaaaattttt cacacatact cataaaaaaa ctatccaagt
    14461 atattactta gatagtttta tattatatgt aaagaaagag ctgaaactat aacccctgat
    14521 aacaaattac caagaaatac tcccataaaa gcatctttta ttctcatttt taatatggaa
    14581 gctatagcag atgcagtcca tgttcctgta gttggcagtg gtatacctac aaatagtatt
    14641 ataccaatta tcgaaacact ttttaatttc ttcattcttg agtttatttt tctatcaatt
    14701 acatcagcaa tccctttaaa tagtttcttc cctcttaaaa attgtaatac atgtctgaat
    14761 gtcaatatca agggaatcga taccaatgta gaacctatta cactaaatac ataaacccat
    14821 ataggattta agcccattgc aatacctata ggaatggctc ccctcaattc tgttacagga
    14881 accatagata aaattaatat gtgtaaatat cccaaactat tccctcctat tctaagtgac
    14941 attaagttat gaatttattt gctctataac ctcaccatcc tttttactaa ctaaaaatgc
    15001 atttttagtc aatgaaagca ttggtaaatc actcttagag tctgaatatg catatgaatt
    15061 ttcataatca atctctatcc caagtttacc taatacagcc tttattcttt ttaatttttc
    15121 aattccctta caattttctc caatgaattg atttttatat cttgaatttt cataaaaaaa
    15181 ctccgtgcct ataacctcgt ctgcaagacc ataatactta aaatatttca tatatgcata
    15241 tggagatgca gttatcataa ttataacatt atcttcttct ttatttttgt aaataacctt
    15301 tttcatagat tcgttaattt ttttcattat gcaatcatca aaaaactttt ttaaatcttc
    15361 ttcactaaaa tctactattg gataaaagat tgcctctttt gccttcttca aaggtatcat
    15421 tctaattaaa tacataaata gaataaaaat aatgtatggc aactttataa tagttttaaa
    15481 ggttttattt tttaaagagt aaataaaaaa atctatcatg ctatcagtat ttataacagt
    15541 ataatctaca tcaagtaata atacactttt tttcataagt atttccccat cctatcacta
    15601 aaaatatcac taaaaaatca atattattaa acatgtaatt atccataaga ttacgtttat
    15661 ttttaaagca ttatctttta ggacaatatc agtaggatta ttttcatttg tagtgttaat
    15721 tatataatta tatctaagta caccataaac tacaaatatt gttgtaaata tcatatgtgg
    15781 cttttctgga ttacttgtag aatacaatgc ataacataca attgtagaac ttaatataac
    15841 tatcatcatt tgatttagat tttctatgtc ataatcttcc aatatttttc tatgttcaac
    15901 tgcatcatct cttagagttt ctatttcttt tttacgtttt ccaagagcta agtacagaga
    15961 taagaaaaat gtacataaaa ttatccaatt tgataaacta acacttatgg ctacacatcc
    16021 tgcataaacc ctaagtataa aaccaagaga tattgaaaac acatctaata gtattatatt
    16081 ctttagttta agagaatata atatattgtt tatcaaatag agactgagaa ttatagaaag
    16141 attaaaacta acaactgttg ataaacagac tgaaattaaa gctaatacta caaatagtat
    16201 attagcactt tttttgctta ttcttccact tgccactggt ctattacatt ttttaggatg
    16261 ttttttatct ttatccatgt ctatagcatc attcagtgca tatactgatg atgacattag
    16321 gcaaaaacac acaaacgcaa taaacgtatt taaaaataaa tttatattta gtatgttgtt
    16381 tgaaaaaatt atagctgaaa atacaaagaa attctttata tattgcttta ttctcattaa
    16441 ctttatataa tctgaaattt tagtaagaag ccttatactt gtattggtct gtttcataaa
    16501 cttactaccc tttcaatatt attttttaaa caggatatga ttttatccct atgtttaaaa
    16561 tttctataaa tccattgaca ttactgatta ctatagtaac caataacagc gatagaaata
    16621 tattatacat attcttttca ttttttctaa gcgctttcgt aaagtaagcc aataaaatta
    16681 taactgcaaa actaaaattt atagccataa tacttgaatt gactagatta tatcctacta
    16741 taccatgtaa agttagattg aatataatta ttcccataca tagcttagga actctttttt
    16801 ctgaattttc aataactgat aaaacacaaa aacataaagc taataatgta agaattactg
    16861 gtattgtagc aacttctcca ttttgcaaaa ataacccttt tttaatgctt gctccaggaa
    16921 aataaaaaac cgaatacaat aatctctcta taatcattgc aatcttttcc aaaattggtt
    16981 ctccacttat aaatttcgta tcatactgta ttacatttcc aaggttcata aaactctcat
    17041 aagacttcgt tgaaactaca caaatatatg ccattaggat aaatgtaatt aaatgtttta
    17101 acatttttcc tatttttaat ttaaactcaa atatcatatt aaaaaaatac aaatatatat
    17161 tactaatagt tattccaaat agaggaatag ctgctaattc tactaaataa gaattttttc
    17221 ctttcatctt atttgcaata actatgaaaa atattaatga aaattggcta tatataaatc
    17281 tctctacatt taaagtcata aatagctgtg gaaaagaaaa tatcattatc atagtaagta
    17341 aaattaaagt taatctctgc atttttatct ttttaatatg attaaagact aaagttattg
    17401 acatagcact agttattatt tgtagacaaa ttagtccaaa cccataggca ctattaaaat
    17461 ctgttgtccc aggatttgct attgaagtac aaaataggta tattggatat gcaaaaattg
    17521 atataattgc tgaaaacaat atgtgcttac tattgtcttg acttatagca aatacattta
    17581 aattgaataa aactcctgta tctgtatcta acaatacatc ataagtattg tttaaatcat
    17641 aaaatatagt agtcttagaa aaaaatatct tagttattat taagtaagtt attacaacta
    17701 atataaacaa aaacatctcg tttttatatt ttaatatttt actcatcaat atatcaccat
    17761 ccattcatta tataggattt gctgacacct acaatttatt ccttatattt aatagccatc
    17821 ttcataatgt tcttacttgt tttattgtaa ttgaataact ctttatttac aaccacaata
    17881 tttactttat tgatgttata atcagtcaag tattgtttat ataacataga ttagtgttgt
    17941 ataaaatgag aatttgtaag caatattaat gtaaaatatt tgaaaaactt tatataaaaa
    18001 tatacaatgt tgcttatgga attaaactat aacaaattaa agcataattt aaggagacaa
    18061 aattataatc tgtctcctta aatattaaaa ctatatttta aaacattact aaatactata
    18121 caaatttcaa atatagtata aaattaatta gactttaaca ctattagctc catcttcttc
    18181 ccatttttta atttctttta atctatctat tataggtaaa tgctgagtac attcaacttc
    18241 acattttcca caagatatac attctttagc ttttgcctta ctattcattg tgtaattcca
    18301 atgtcctaag ccataaacta actttgtcat ttcttcatca ctctttttaa acatctgctt
    18361 ttcattataa aaaagcatat aggctggggt attaatacct tttggacata ctttacaata
    18421 accacaacct gtacatattt cgttcatatt cttatttaat ctagtctcaa tatcatgtat
    18481 atcctcatct gaataaattc tattttcgtc tgcaatttta catgcatcat ctatatcttg
    18541 ttttttatta aaccctatca aagatatact tatttgtgaa attcctatgt tgaatcttaa
    18601 agctgattct atagtacttt cgccatcttt tgatagaaaa gaaagttctt tattatactt
    18661 tggaatagtt ccaccactta atggattcat tgccacaaca ccatatccat tatcaacagc
    18721 atatttggca ccttttagcc tatatggaaa gtttaatata tttattccca tagttacacc
    18781 ttcaaactta ttttcactta gaatatctat aacctcatct cctggttgat gagatgaaaa
    18841 tactatatgg tctatcaatc cttcttcttt acatttcaat aatccttcat attgacctcc
    18901 aggtctcatt gctagttcgt aatgttccat ctttctaata ttccaaacat gataaaaatt
    18961 tattttagat acgcctaatc gttctattga tttttttaca gcctctatag ctttttctga
    19021 tgtatcacat gcttttggct tttctttagt tgatacataa aaatcggtct taccttcctt
    19081 tatcatttgt ctaaaggcta gtccaaatat atcttcactt ctgtcatcac aataccctgg
    19141 tgctgtatca aagtaattaa tacctttttc atacgcatat ttgactaaat cagcattttc
    19201 ttgattactt ttttctaaat caaaccttaa tcctccatag ccaactactg aaaccatttt
    19261 ccctgtcttt ccatattcaa cgtatctcat tgtaaattcc tccttagata tattaagact
    19321 taatttcttt atagaaaata ttataccata aataattttt ataaattatt tatggtataa
    19381 tatttttttt ataaattata tttttttata acttgtattt tataactaag ttaaaaacta
    19441 taaaaaggtt caatatggac tattacttga gcattttcat taatttcttc ttgtatttgt
    19501 ttctcaattt tatgtgttaa atcatgagat tgctctacgc ttataaatgg atctaccatt
    19561 acatgcatgt caatataaat agaacttttg ctacctctac ttctgatatt gtgaacatcc
    19621 cttacctcat taaattcaaa cacaatttct tttatataat cctcatctac agccactcta
    19681 tcgaccaaaa ttccaataga tggcctaaat attccataag ccgaataaat tatgaatgca
    19741 gaaataataa taggaactat agattctatt attactggaa atcctaactt aacaccaact
    19801 aaagtaacca atacacctag agacacaaat atatcacttc ttgtatgcaa tgaatccgaa
    19861 atcaaaacat aactatttag tttagtccca attctatatt catacatgca tacaaaaata
    19921 tttataaaaa gtgtaataat taaagcaatt aaactttcta tagttatagc aggtacaact
    19981 ggattagcta ttcttaacac tgcactaaga attatcttaa ttgctataac aaacaacata
    20041 ccacttataa ataaactggt tataatttca aactttttat gtccataagg atgattttta
    20101 tcttttggtt tagatgcaaa gaaaatacct ataagcccca ctatattaga tgctccatct
    20161 gacaaagaat gaaatccgtc tgctgtcata ctatagcttt ttatttgatt accaataatg
    20221 atttttaata atgctactgc aaaattagca aataaaatta tccacaatac ttgcttcact
    20281 ttcttatagt tatccataac aaattccccc tcccttcgat tcaataaaga aagctatcta
    20341 tcaatatcaa tcaaccagac aataaaatcg tatataagca catttactat atttatattc
    20401 aaaattggtt gtacttgttc attctatttg aaacttaatt ataaataaaa atcgtaggta
    20461 tggttttggt atacataaaa ataagagact gtctcaaaat aaagataatc ttctttttta
    20521 ttgttgaaat gataaaatat atttgatttc atataaaaaa gagtgcctca tgaactaaaa
    20581 agttcatttt gagacactcc cttaaatttt tgatataaac tattaatttt ttatactaag
    20641 ccttctttaa ctaagaatga atgagcaact tcttctggtg atttaccaag ttcatccact
    20701 tgatagttaa gttctctcat agtttcttca tttatttttc ctgaaagcat attcataact
    20761 ttttctaact caggatattt cttcaaagta tcttctctta ctaatggtgc tgcataatat
    20821 ggtacaaaga aatttttatc gtcctctaat atcttaagat taaacttttt aataagacca
    20881 tcagttaaaa atgcatctat aacctgagat tcattattat ctaaagctgt atatcttaaa
    20941 cttccattca ttgcttttac atctttgaat tttaaaccat aatctctaga aagccctaca
    21001 agaccatctt ctctattttc aaactccaaa gttggtgaga atgtaaattc tttaccatat
    21061 ttagtcaaat cagaaatagt atttattcca tacttttcag cagtttcagg catcatagct
    21121 aatgtgtaag tattattaaa tccaagaggg tcaagtaaag ttaactgatt ttctttttcc
    21181 atagtatctt ttacaacatt atatgcttca tcagcatctt taatcggagc atgtttcatt
    21241 acatttacca aaagtgtacc tgtatagtca acatacatgt ctaactcacc agatttaatt
    21301 gcattaaacg caacagatga accacctaga tttaaattct tcttaacttt aagattcgta
    21361 tttttttcta ctaattcagc ataaacatta ccaagtataa gttgttctgt ataatcttta
    21421 gaaccaatag ttattgtatc ttttttactt gaaaaactag aactaaaaac aacgaacaac
    21481 attgaaacaa caaccactac agatattact ttaagtgcta tataattctt cttaggtgct
    21541 tttggattta atccttttgg agtaactgca acttcaattt tactaaataa ataatcaact
    21601 aacagtgcaa ttatacatga tgggattgcc cctgctaaaa tcatattatt atttacagtt
    21661 tgaacccctg aaaatactaa atatcccaaa ccaccagcac ctataaatgc tgcaagagtc
    21721 atcaaaccaa cagctgtaac tgcagatatt ctaactccac ccattattat aggaagcgct
    21781 aaaggaaatt gtattttaaa taatgtctga tttcttgtaa gaccaatacc tttagctgat
    21841 tctaatacta ctgggtcaat acttgttata cctatatacg tattttttac aattggtagt
    21901 aatgaataaa ccactaccat aaatatggct ggtttacttc ctataccaag tataggtaca
    21961 agaagaccca aaagtgccat agacggaact gcttggacta agtttacaaa tccaagtaca
    22021 aactttctaa gagatgagat tcttgaaata attattccaa gaggaacacc aactattata
    22081 gctattaaaa tagatgtaac agttagactc atatgttgta ttaaaagctc tataatctta
    22141 tctttttgta atagtataaa gttaaaaaaa ttagccaaga acactcacct ccatttctaa
    22201 gaattgttca cttaaaacag aaagtaaact acttctagta ataagcccta ccagtttatt
    22261 ttcatcagaa ataaccggaa tatatccaac cgaattacga ttcattacat ttagtatttc
    22321 tactaaatta tcaccttcat ttacatgcaa aggctcactt gacataatat cagcaagtaa
    22381 tattgactta tcatcaatat ctttcatatc ttttacagta acaatacctt ttaatgtttt
    22441 tgctctatct ataattagta agctatcaac cttactcgtt ctcataattt ctattccttg
    22501 agttacagtt ctagtagaat taacagcaat aggatttttt atcataatat ctcttgcttt
    22561 tatatattct ggattatccc aaactctatc ttctccgata aaatctttta caaagtcatt
    22621 tgcaggcttt ctaagtatat tttcgggagt atcatattgt gctattcttc catccttcat
    22681 aatacaaatt ttatcagcta tctttaaagc ctcatccata tcatgagtta caaatattat
    22741 agtttttttc aattcatctt gaagagaaaa taattgttct tgtaaagatg ttctcgttat
    22801 tgggtctaaa gcactaaaag gctcatccat caatattatt tcagcatcag tagcaatggc
    22861 tcttgcaaca ccgattcttt gttgctgtcc accactaagt tctgaaggat acttattcaa
    22921 aaattcatca ctatcaagtc ctaccatctc aagtagttgc aacgttcttt tttcaatttc
    22981 ttcaacggat ttttcctttt ttaggcgtgg aattagctct atattttctt ttattgtaag
    23041 atgagggaat aggcctgtgt tctgtataac atatcctatt tttcttctaa gctctatttc
    23101 attttcctga gaaattggtt tgccattaat atatatctca ccagatgtag gttttattaa
    23161 tttgtttata agcttcaaag tagtagtctt tccacaacca cttgaaccaa tcaaaactac
    23221 caatgtacct gtttctacaa ctagagaaat atcatctaat ataacattat ttcctatttt
    23281 ttttgttaca tttcttatct ctatcataat ttatcatccc ctttttcgaa caagcaacct
    23341 tcttcaatat tataagttgt ttttataatt atatcatact attttattta tgtaaacaaa
    23401 gtacgatttt taggtcacta tttgtctgaa tattgctaca aat
//
LOCUS       DAEQCW010000056        23296 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.056, whole genome shotgun sequence.
ACCESSION   DAEQCW010000056 DAEQCW010000000
VERSION     DAEQCW010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23296)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23296)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23296
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.056"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..988
                     /locus_tag="KRO40_002194"
     CDS             <1..988
                     /locus_tag="KRO40_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBH2093011.1"
                     /translation="DIKLIPKIIRLVNKTYIFLGILTIIVYMIIESIVTHLIINAVQK
                     TKVKFIGIKMATMGFYYNLVTPFASGSQPMQIYALTKYDVSLSKSVAIVTNKTVVFQS
                     TVTVFCGILILLNKSLLMEQVHSVKVLITFGMIMNVSMLLGGLLIVFSPKQVKMIAEV
                     LINFLSKFKTFKFLDSKRDRINHYIDDYNYSIKIFIKNVRILVLSILLTVLQLIAYFS
                     IVYCVYKASNLRGVSYVHIMTLQVFLYMAISPIPTPGNVGANEVTFFTMFSNIIPKEL
                     LGYSVLLYSGFVYYFILIVSGLFTFGTHYTLNSWKKEDKVNSNLDKVIEKLN"
     gene            1137..1298
                     /locus_tag="KRO40_002195"
     CDS             1137..1298
                     /locus_tag="KRO40_002195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III"
                     /protein_id="HBH2093012.1"
                     /translation="MKQDKQNEKQSEISKIKQSNDNKLEIAQELHVSKNIGNMLGYRI
                     DKKKMNRPS"
     gene            1639..2907
                     /locus_tag="KRO40_002196"
     CDS             1639..2907
                     /locus_tag="KRO40_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBH2093013.1"
                     /translation="MEASIHTIASNNLLIIFAIVSITGIICSKLSEIIKVPDVVLYLL
                     VGILIGPSFLKFIDIRGFQIENQLILTFGSAFILYLGGKEISLKVLRNVKISVFLLAT
                     LGVVISAFIMQQVIGFTFGISAMTALLAGTIIASTDPATLVPIFNQVKIKDRVKQTVI
                     SESAFNDATGAILTSAVLAVILSNKFSLGENIYELGTMVIVGVLVGLITGILLLKLVN
                     DKPYGIFKDFAPIISVISVVVAYELSTKLGGSGYMSCFIVGIITGNKKNFKIWLSQKS
                     YDADFYVAETLGTICRMAIFIILGSQVNLAQLSKYFMPSVITVLVLMFIARPLCVLVC
                     TLVDREAKWSKSEILFMMWVRETGVIPAALCGIISAMKVPGYEVISSVVFMTILITLV
                     IQGSTTKLVAKKLGLLEEEVINISEKVSTF"
     gene            3102..3890
                     /locus_tag="KRO40_002197"
     CDS             3102..3890
                     /locus_tag="KRO40_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH2093014.1"
                     /translation="MFTVMDIVQPDTVEEAYSILNKRKTNQVIGGSAFLRMGKKRIGT
                     GIELSKLNLDYIKEYEDYVEIGSMTTFRTLETSSIIKNNFGRIIEDSVKNIIGVQFRN
                     VVTVGATVFSKYGFSDLIVALLSLDTEVELYNIGRISLEEFLNRDYEKDLLIKIYIKK
                     TNKNASYKSLRNAKSDYPILNVSVSKHMEQFKLCVGARPQKATIAKQASEFLSNNEIN
                     EINIDKAVEIASEELTFGSNMRASREYRKAMSKVLLKRAIMEVI"
     gene            3890..4339
                     /locus_tag="KRO40_002198"
     CDS             3890..4339
                     /locus_tag="KRO40_002198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBH2093015.1"
                     /translation="MLVKININGKKKSVDIEPEEYLVDTLRKVGNLSVKRGCDTGCCG
                     LCTVLIDKKPTLSCATLTLRALDKEITTIEGLENEVKEFSEVLVKEGAEQCGFCSPGF
                     ILTVLAMKDELENPTDDEIKHYLTGNLCRCTGYMGQLRAIKTYLEVK"
     gene            4343..6607
                     /locus_tag="KRO40_002199"
     CDS             4343..6607
                     /locus_tag="KRO40_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2093016.1"
                     /translation="MNIVGKGIKKIDGMSITTGKPVYTDDLSAKDALVVKILRSPHAY
                     AKIKDIDTSKAEMVDGVECVLTYKDVPKSRFTLAGQTYPEPSPYDRLILEDVVRYVGD
                     EVAIVAAIDEKTAIKAMNLIKVKYEVLTPVLDFEEAIGNKTMVHDEDRHCNFDIGMQR
                     EKNIVSHHDYTKGDVEKVLSNCDVVIEETYYTQAQAHAMMETYRAYNYLDHMGRLVVV
                     SSTQIPFHVKRHLSRALEIPASKIRVIKPRIGGGFGGKQTACVEIFSAIVTLKTGKPA
                     KIIYDRKETFNCSTSRHAMRLKVRLGATNDGIIKAIDIKALSDTGAYGEHASTTIGLV
                     GEKTLPMYNKVEATRFIADVVYTNKMPAGALRGYGASQGCFAVESTINMLANKLKMDP
                     TDLRLKNVVTEGETTFAYGKTLNSVDLIKCINKGKELIGWNEKYPCKHLDNGKIRSVG
                     MAITMQGSGIQGLDKSSAEIKLNDCGDYTLMIGSTDMGTGSDTILAQMAAEVLDTSIE
                     NITVISADTDLVPYDPGSYASSTTYVTGMAVVKAAQDLREKIISAGATKLGVEKDEVE
                     FDGIKLTSKKGSTLLFDIAVDSTIGPDTNQLIGLASHGSPVSPPPFIAGFAETEIDTE
                     TGKVDLVNYVAVVDCGTVINKNLAKIQVEGGIVQGIGMSLFEEVRYTEKGSMDTNTFM
                     QYKIPARCDIGNVKVDFVETYEPTGPFGAKSVGEVVINTPLPAIQEAVFNGIGVRINT
                     LPITPEKVFMEMNK"
     gene            6747..7058
                     /locus_tag="KRO40_002200"
     CDS             6747..7058
                     /locus_tag="KRO40_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093017.1"
                     /translation="MAGNLNNMRAVNNFRGDKNILECLVSFEGRSISQRKVRVFFKEK
                     QNQIEIDFAEEEISKLVENVVLNTSYQEMLYDEIEKQLEIDCIGTWMILSKLKDGSRV
                     H"
     gene            7344..7844
                     /locus_tag="KRO40_002201"
     CDS             7344..7844
                     /locus_tag="KRO40_002201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HBH2093018.1"
                     /translation="MRKNSINIALTAAITAIYAVLTLSLGFISYGPIQFRVAEIMMLL
                     AFLDKGYIVGLTLGCFLANVIGPYGVPDIIFGTLATFISASMIYITRKLGKQNKSTLV
                     IASLWPTVINSIVVGLMLNVFFGLPLILSMIQVGFGEFVVVTIVGVPFFCFLMKKYKN
                     VINIKF"
     gene            7901..8887
                     /locus_tag="KRO40_002202"
     CDS             7901..8887
                     /locus_tag="KRO40_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH2093019.1"
                     /translation="MSKVKRLTDVWIYINDKQKFTIKELSEEFNLSAKTIQRYLKELN
                     KMGLPIQAEQGRNGGYRVLNNSYIPPVIFTEKEVMIILFALKSLQIYNYKLMEIEINS
                     IMRKVSYERKSSIKVGIENIKRYIGFVANDTNDGDFKSSNVTEFFRASSESLILNIKY
                     KCGNQILEKNVCPIGIYLNKGAWFSPAYDCKSDKIILVHIDNIIDIKRTGESKKIHIN
                     LEEWLHEVYNNLYGNSSTTKKFGEIIYLNVLLTKEGVSKIKDSSWNLDMELNEDGSGI
                     ISTFIKVEDIDCYASILFFIGNNAKVIEPKFLNKLLYDKANELRYFYEENMV"
     gene            8937..9659
                     /locus_tag="KRO40_002203"
     CDS             8937..9659
                     /locus_tag="KRO40_002203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein"
                     /protein_id="HBH2093020.1"
                     /translation="MENFNKNAKIIGIGAEGINIINEVEEKIKANMDIEKININQEIE
                     KEYVRSLLDGVDILFLIYSSEDKHIRDIIKAVSYMSNERRVLSIGMDCSEKENKEDLE
                     LGREFKINNDSIFKFVDLMNIMVESISDSCMINIDITDLKEAIVGDKGIKYSFEEFED
                     TKSYSEIADILFDRMEYIGEEFISKKGIVFVEGSPEFSIMELNDLISNIQSKVEESYE
                     VIFSLYIKENLNGNIRVGLLYN"
     gene            9688..11622
                     /locus_tag="KRO40_002204"
     CDS             9688..11622
                     /locus_tag="KRO40_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2093021.1"
                     /translation="MSENIRGTEYWLMEEFFYQETDTPQIFREESIIALGFDIKINLK
                     KVFSMGKKSEKYINENCNDKDFIKKFMSIKKGDYFLYKAYQNIEEKVKCNVSIGIVEE
                     DFENGYELSHILGHTLPVKWMHNFDTVSNCKVYTSEFYKLNNNDISSYLEIIKSQDKK
                     LLRKRIEESENNKWYLKNYYYKNVDKCVDDEELFIQPINLEQLESLKNIKTDDYILLY
                     NSEKVICENDHTMKSLFGVCQVMEGFDKEKVSALEGGYFFPVRWIEYEKENIDGNAWV
                     IFENNSIVEKYVKRFTNKMPLNTILYGPPGTGKTYNTKQMVYNLVSETSLRNRYYTGY
                     LDYKNNVEFCTFHQSYGYEEFIEGLKSDGEGNFKPEDGILKDISIEACYNALKFEKKM
                     SFELEKDSLTLETIKDRKKKLVLENIEYSESFNFEESENYVLIIDEINRGNVSKIFGE
                     LITLLEDDKRLTKSNQTIVKLPYSKEKFSLPPNLYIVGTMNTSDKSIALLDIALRRRF
                     NFEEIMPDYDLLSIVDGIDIRKMLYTINKRIEFLYDRDHVIGQAYLLAVENINDIVVV
                     FRSKIIPLLQEYFYYDSEKVGLILGGIGRNEKDKYIVYKEKLIASELFKNNNASIMES
                     KVNYCIKQNISSEELKNIYE"
     gene            11615..12883
                     /locus_tag="KRO40_002205"
     CDS             11615..12883
                     /locus_tag="KRO40_002205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HBH2093022.1"
                     /translation="MSKNIYVKETYEWIRIGNGENELTEIEYEKLLKYLENNNDVLKS
                     NIIDIKYKKLRFINYVGIICFENVILEILPKLSLSDNLVKDREILLQMLSICNKIPIT
                     MNEKIRLSLKNYNLLNFFVMYFIESMQTQMKKGIYFEYINKIENLNVMRGKILLSTYA
                     KEKGISPMKIRCEYDEYSENNFLNQVLKKACISILCRINDNSIQGKIKKILSYFQNVD
                     LIYIDRKKLLDYKFYKNNDRFKDCYLLARLLLLNLSMDNSQNNQEAFSILFEINTLYE
                     EYIGILIKSIWDNSFRETYIQDKSKFLLKNEQTGKKNFNLRPDIVLYDLKNEYEIIID
                     TKWKAIEVDSNVFYRSSDIYQMYAYITAYENAKRCILLYPCIQKDKNYSSWKLSESFK
                     GKFIEAKTVRLDDIKNTKNDLKKIIFNYKF"
     gene            13210..14250
                     /locus_tag="KRO40_002206"
     CDS             13210..14250
                     /locus_tag="KRO40_002206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093023.1"
                     /translation="MDKHSDSVMYGGMEVYNIWGTTTVDSIIGESDVMRALKNRICKI
                     GNSDSTVAITGESGTGKELIARAIHLAGNRGNKTFVAINCAAIPEPLLESELFGYTKG
                     AFSGADSKGKIGKFELANGGVVFLDEIGDMPIQLQSKLLRVLQEKKFTRIGSNELIDI
                     DVRIISATNRDLFELVKENKFREDLYYRLNVIPLEVPPLRERGDDIQILINNFIDKYS
                     RKMKKNVYHIEPDVEQMLLKYPWPGNIRELENTIELALNLLEEDGIIHKGIINRKILE
                     YFKLNNINIKLLEESDYEISMEQDILTLEEFERAYIKKVLKFYGNDTKSKKLAAKKLG
                     ISLATLYRKIDV"
     gene            14578..15924
                     /locus_tag="KRO40_002207"
     CDS             14578..15924
                     /locus_tag="KRO40_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBH2093024.1"
                     /translation="MSKYQKNVSMFDIDGRPPILKCLPLSMQHILAMIVGTVTVPIVV
                     GGAVGVSPTQITLLVQYALIIAGISTLIQLYPIGNIGSRLPIIFGVGFTYVPTLVAVG
                     GNYGLASILGAQLIGGVATVLIGIFIKKIRKFFPNIVAGTVVFTIGLSLYPIAINYMA
                     GGVNSPTYASMQNWAVAAITLVVVIGLSQFAKGYAKLAAIFLGIIVGYCVSLVLGIIN
                     FDPIREATWFAIPKPLEFGMEFDMPVIISVVIVSIINAVQAIGDLSATTMGGMDRNIT
                     DKELSSGVIGSGICTMIGALFGGLPSSYSQNVGMVAMNKVISRFVLGIAGIFMLLSGF
                     VPKFGALMTTIPYSVLGGATISIFSMITMTGIKLIITEELSSRNITIVGLAIALGMGI
                     TSVPAAQEAFPSFVKLVFGESPIVIATLVAFVLNLIIPNKSLEDEAKERAVMEETN"
     gene            16221..17582
                     /locus_tag="KRO40_002208"
     CDS             16221..17582
                     /locus_tag="KRO40_002208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBH2093025.1"
                     /translation="MKTRNTSKYDVDGIPPLKESIPLALQHLLAMIVGNMVPAILIAN
                     VVGLNQGQATMLIQGSMLAAGLATFLQLYPIPLFKGFKLGSRLPVMMGMSYVFLGACL
                     SVAAKDGLAALFGAQIAAGVIVFFVGFGVKKIRHIFTPIVSGTIIACMGLGLFATAIK
                     NLAGGEGTQTFGSPINFTVGVIVAFVIIMINKYGKGLVKNSSILIGILVGYAISLVLG
                     LVDFSAVQGAAIVSLPTPAAFGLEFRPELIVMFTIIYIIGIADMMGACTIATVGAMDR
                     EVTDEELASVVLGNSITSIISSLFAALPTGVFSQNTVIVSMNKVTSRFVIALGALVLL
                     LAGISPALGAIMTTIPSCVVGGATLVVFSSIAMSGFSIMSMDGFTEENNLIAGVSIAT
                     SMGLTTAPQVLDQFPETIGTVLGGSSIVSGAIIAILLQTLFKLKSRKSAENVTSNLEE
                     NIG"
     gene            17655..19049
                     /locus_tag="KRO40_002209"
     CDS             17655..19049
                     /locus_tag="KRO40_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093026.1"
                     /translation="MIDILIKNAIIVTVNKDRDVIFDGAIAIQGDRILDIGNTVDIEP
                     KYLDAKKVIDANGKVIFPGFINTHNHLFQVLLKGLGDDMALHEWLNTMMFPSAKFLTE
                     QDTYDAAMLGCMEGLKSGITTMVDYMHTHNRPGLTDGIVKAYKDLGIRGVVGRGCIDL
                     GIHKELIEDVETVEKDLRRVFEKYHNSENGRIKICVAPSSMWAISEEMGKMLWNIVKE
                     YDSYFTVHISETEFARTATKDIHGEIDIKLLEKWGIVGPEVVAVHCVCITDEDMEMLK
                     KYDIKVSHNVASNMYLASGVAPVPEMLKKGINVSLGLDGAASNNAQDMVELMKLTALQ
                     HKVNNCDPLAISAEKVLEMATIEGARTLRMEDEIGSLEIGKKADLVIFNSMLSPKSIP
                     LHNPVSTLVYSASMHNVESVLVDGNVILENGKVTTIESEEQVLLNAQHAAEELCKRAN
                     VTNRMEGHKWNSLY"
     gene            19111..19581
                     /locus_tag="KRO40_002210"
     CDS             19111..19581
                     /locus_tag="KRO40_002210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="HBH2093027.1"
                     /translation="MEKIKLNINDYMYEIEVEKNETLLHVLREKLNLTGAKQGCNSGS
                     CGACKVLIDGVDMKSCKLLAKNCEGKVIYTIESFANGENLHPIQEAFIEVGAVQCGYC
                     TPGMIITTQALLNRNASPNEDEIREAFKENLCRCTGYVKIIEAVKLSAARLGGR"
     gene            19584..21800
                     /locus_tag="KRO40_002211"
     CDS             19584..21800
                     /locus_tag="KRO40_002211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2093028.1"
                     /translation="MEKVIGKSYPLKDAALKVTGQMKYVADMKPQNVLYAKMLLSPVA
                     HAKIKSIDTSEAEKVVGVRAIATYLNTSQRKYNGSLRFYEHKIPENEVIFSDTVRFVG
                     DRVAAVAAETPEIAEKAVKLIKVEYEELPAVFTIQDAIKEDAICIHGDSNIVSQNNIN
                     GGDVEKGFKECDYIFEDEYSTPAIHHSAIETHSVIAHYDYNDKLTVHTPCQNTFGFRI
                     ILSQIFGMSLNKVRVIRPAIGGSFGGKLELTIEPVAAALSKMTRRPVKMVLTRKESMI
                     STRTRHGSFVKLKTGVNKDGEVIAQDIKIYTNTGAYASSALNVIGALSHKVFKVYKIP
                     NIKFTGMPVYTNTPIAGAMRGYGSPQIFMAQQAQFAKIAKEIGMDLVDFQNKNAVEPD
                     DVDIIFHGSLGNPRVLDCIEQGKKMFKWDEKKKLPKEEGKYLRGIGMAIGAHGNGVFG
                     AHRDVVTLTLKLNEDGTLTLLTGAHDMGNGVVTMQTMMVAEVLGITPDKVDTFETDTD
                     ACTFNLGDYASRGVFVEGGGAKKTAEKLKNLILEEAEKLLETSKEDLYLDNGCVISKL
                     DENVKASLSDVAVYSQSKSLRELTVVEDYSSPAGRTSYGVHFAEVLVDKETKDIKVVD
                     FVAVHDVGRVINPLNLEGQLEGGIHMGLGYALSEELAFDEQGRPKATDFKTYKLFRTV
                     DMPKCQVAFVDGYEKAGPFGGKSIGECAVVPVAPAVANAVYNATDVEIHSLPIKLK"
     gene            21883..22554
                     /locus_tag="KRO40_002212"
     CDS             21883..22554
                     /locus_tag="KRO40_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2093029.1"
                     /translation="MAKILGICGSPRKGATEYAVLEALKEAETIPGIETEYWSVRGKK
                     ISPCVHCDACIRKETMCIIKDDIQELEQKILEADGIIVGSPVYDMNITAQLTAVFNRL
                     RPMYLVHPGKLQNKVGAAITTGGTRYGGQELTKLPIINFFLMHEMLVSGGLGGCYIGG
                     TIWSKDGKAKGAQEDETGMDTVKRLGKGAAEAVMVSKFGLEKWNVVKEELDVKKDEKS
                     PLRDH"
     gene            22917..>23296
                     /locus_tag="KRO40_002213"
     CDS             22917..>23296
                     /locus_tag="KRO40_002213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="HBH2093030.1"
                     /translation="MLKEIKWKVNNLPKGDKENCIKFLNEEEITKVRNFHKSFPQYKE
                     TPLANLEGLAKKLGVAGVYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLDTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGN"
BASE COUNT         9124 a         2365 c         4334 g         7473 t
ORIGIN      
        1 agatataaaa ctaataccta aaattataag gctagtaaat aagacttata tatttcttgg
       61 catattgaca attatagtat atatgataat tgaatctatt gtaactcatt tgataataaa
      121 tgcagttcaa aaaacaaaag taaaatttat tggtattaaa atggctacaa tgggatttta
      181 ctataactta gttactccat ttgcatctgg gagtcaacca atgcaaatat atgcacttac
      241 aaaatatgat gtaagcctta gtaaatcagt ggctatagtt actaataaaa ctgtagtatt
      301 tcaaagtaca gttactgtat tttgtggaat tttaattttg ctaaataagt cattactgat
      361 ggagcaagta cattctgtga aagtcttgat aacttttgga atgattatga atgtaagtat
      421 gttgttaggt ggactactaa tagtatttag tccaaaacaa gtaaaaatga tagcagaagt
      481 tttgattaat tttttatcta aatttaaaac atttaaattt ttagattcaa aacgtgatag
      541 aataaatcat tatattgatg attataatta ttctataaaa atatttatta aaaatgtaag
      601 aatcttagtt ttaagtatat tacttactgt gttacaatta atcgcatatt tcagtatagt
      661 ttattgtgtg tataaagcct caaatttaag aggagtttca tatgtacata taatgacatt
      721 acaggtcttt ttatatatgg ctatatcacc aattccaaca ccaggaaatg ttggagctaa
      781 tgaggttaca ttttttacta tgttctccaa tataattcca aaagaattat tggggtactc
      841 tgtactctta tatagtgggt ttgtatacta ttttatatta atagtttcag gtttatttac
      901 atttggaacg cattatacat taaattcttg gaaaaaggaa gataaagtaa attctaattt
      961 agataaggtt attgaaaaat taaattaata aaataattag ggaaattcta tatataaata
     1021 tggtgttgaa taagctatat tatattgaga tatttccctt ttttgattaa aattatagaa
     1081 atttgaaata ataagtaata aacagaaaaa gtgatattgt tttgaaagga gaaactatga
     1141 aacaagataa acaaaatgaa aaacaaagtg agatttctaa gataaaacaa agcaatgata
     1201 ataaacttga aatagctcaa gaattacatg taagtaaaaa tatagggaat atgcttggat
     1261 atagaataga taagaaaaaa atgaatagac caagttaatg aaaatgttga aaatggtaca
     1321 ttttaaaaaa tatatataat gaaatgtttt attgttaaat ttaaacttat tttaatggag
     1381 gaaaaagtcg aaaaatatct aaaaagatat ggatataaaa aatattaata tatatatact
     1441 ataaacttga caaaatcaac cttttaataa ctagcaaaaa atagcaaaat tatataagcg
     1501 ttatttaatt gtcaaaaatg aaagctaaat tgcatgtcct aaaaaaaatg attgataaca
     1561 tttatttgtg tgctataatt atatagtaaa acaataagta tattgcataa tgtatgcaaa
     1621 tcgggaggag agacggacat ggaagcatct atacacacaa ttgccagcaa taatttattg
     1681 ataatttttg ctattgtaag tataactgga ataatttgta gtaagcttag tgaaataata
     1741 aaggttccag atgtagtgtt atatttactt gtaggtattt taataggacc atcattttta
     1801 aaatttatag atattcgtgg atttcaaata gaaaatcaac taatacttac atttggttct
     1861 gcatttattt tatatttagg tggaaaagaa ataagtttaa aagtattgag aaatgtgaag
     1921 atatctgtat tcttattagc tactttagga gttgtgatat ctgcttttat aatgcaacaa
     1981 gtaataggat ttacttttgg gataagtgca atgactgctt tactagcagg aactataata
     2041 gcatcaacag acccagccac tcttgtacct atatttaatc aggtaaagat aaaggatagg
     2101 gtaaaacaaa ctgtaataag tgaatcagct tttaatgatg caacaggagc tatactaaca
     2161 tcagcagtgt tggctgtaat tttgtcaaat aaattttcat taggtgaaaa tatttatgaa
     2221 ctggggacaa tggttattgt cggagtttta gttggtttaa ttacaggaat actgcttttg
     2281 aaattagtta atgataaacc ttatggaata tttaaagatt ttgcaccaat aatatctgtt
     2341 atttcagttg tagttgcata tgaattatct acaaaattag gtggaagtgg atatatgtct
     2401 tgctttattg taggtataat aactggtaac aagaaaaact ttaaaatttg gttaagtcaa
     2461 aaatcttatg atgcagattt ttatgttgct gaaactttag gtactatttg tcgtatggca
     2521 atatttataa tattgggtag ccaagttaat ttggctcagt taagtaaata ttttatgcca
     2581 tctgtaatta cagtattagt attaatgttt atagcaagac cactttgcgt tttagtttgt
     2641 acacttgtag acagggaagc aaaatggagt aaaagtgaaa tattatttat gatgtgggta
     2701 agggaaacag gcgtaatacc agcagcactt tgtggtatta tttcagcaat gaaagttcct
     2761 ggatacgaag tgatttcatc tgtagtattc atgactatac taattacatt agtaatacaa
     2821 ggaagtacta caaaattagt agctaaaaaa cttggattat tagaagaaga agtgataaat
     2881 ataagtgaaa aagtatcaac tttttaaagt tttgctttaa aatagtacct gttaatggct
     2941 attttaatat tgtctaatga tgattattga aatagtcatt tttttatgta taagtaattt
     3001 acagaattta catattagac atatttatta tcaaaatttg ttgaagctat gatataatta
     3061 gttgtattta aaataagaat agcaaataag ggaggaaatt tatgtttacg gttatggata
     3121 ttgtacagcc agatacagta gaagaagcgt actcaatttt aaataaaaga aaaactaacc
     3181 aagtaattgg tggaagtgct tttttaagaa tggggaaaaa aagaatagga acaggaatag
     3241 aattatctaa attaaattta gattatataa aagagtatga agattacgtt gagattggtt
     3301 ctatgactac ttttagaaca ttagaaacaa gttccataat aaaaaataat tttggaagaa
     3361 taatagaaga ttcagttaaa aatataatag gagttcagtt tagaaatgta gtaacagttg
     3421 gtgcaacagt attttctaaa tatggttttt ctgacttgat agtagcatta ctttcattag
     3481 atacagaagt agaattatat aatattggga gaattagtct tgaagagttt ctaaatagag
     3541 attatgagaa agatttactt attaagatat acataaagaa gacaaataag aatgcttctt
     3601 ataaatcact tagaaatgca aagagtgatt atccaattct aaatgtatct gtatcaaaac
     3661 atatggaaca atttaagtta tgtgtaggag caagaccgca gaaagctacg attgcaaaac
     3721 aagctagtga atttctatct aacaatgaaa tcaatgaaat taatatagat aaagcagtag
     3781 aaatagcatc agaagaacta acttttggtt ctaacatgag agcatctagg gagtatagaa
     3841 aagctatgag taaagtactt ttaaaaagag ctataatgga ggttatttaa tgttagtaaa
     3901 gattaatata aatgggaaga aaaaaagtgt tgatatagaa ccagaagaat atctggttga
     3961 tactttaaga aaagttggta atttaagtgt gaaaagaggt tgtgacacag gctgttgtgg
     4021 tttatgtaca gttttaattg acaagaaacc tacattatcc tgtgcaacac tgacattgag
     4081 agctttagat aaagaaataa ctacaattga aggtttagaa aatgaagtta aagaatttag
     4141 tgaagttttg gtaaaagaag gagctgagca atgtggtttc tgttctcctg gctttatact
     4201 tactgtactt gcaatgaagg atgagcttga aaatcctaca gatgatgaaa taaagcatta
     4261 tcttacagga aatctatgta gatgtacagg gtatatggga cagttaagag ctatcaaaac
     4321 ttatctggag gtaaaataga acatgaatat agttggaaaa ggaatcaaga aaatagatgg
     4381 aatgagtatc acaacaggaa agcctgtata tacagatgat ttatcagcaa aagatgcttt
     4441 ggtggtaaag atacttagaa gtcctcacgc ttatgcaaaa ataaaagata tagatacatc
     4501 aaaggcagaa atggttgatg gtgttgaatg tgttttaaca tataaagatg taccaaaatc
     4561 tcgatttaca cttgctggtc aaacatatcc agagccatct ccatatgata gattaattct
     4621 tgaagatgtt gtaagatatg taggtgacga agtagctata gtggcagcta tagatgaaaa
     4681 aactgcaatt aaagcaatga atcttatcaa agtaaagtat gaagtactta cacctgtttt
     4741 ggattttgaa gaggcaatag gaaataaaac tatggtacat gatgaagata gacattgtaa
     4801 ctttgatata ggtatgcaaa gagaaaaaaa tatagtatcc catcatgatt atacaaaagg
     4861 tgatgtagaa aaagtattaa gtaattgtga tgtagtgatt gaagaaactt attatactca
     4921 agctcaagca catgcaatga tggagacgta tagggcatac aattatttag accatatggg
     4981 aagattggtt gtagtaagtt caactcaaat accatttcat gtaaaaagac atttatctcg
     5041 tgcactagaa ataccagcta gcaaaattag ggttataaaa cctagaattg gtggcggatt
     5101 tggtggtaaa caaactgcat gtgttgagat tttttctgca attgttactt taaaaacagg
     5161 gaaaccagct aaaataattt atgatagaaa agaaactttt aattgttcaa caagtagaca
     5221 tgcaatgaga ttaaaagtta gactaggtgc tacaaatgat ggcataataa aggcaataga
     5281 tataaaagca ctttctgata caggagcata tggagagcat gcttctacaa ctattggttt
     5341 ggttggagaa aaaactttac caatgtataa taaagttgaa gcaacaagat ttattgcaga
     5401 tgtggtatat actaataaga tgccagcagg agcacttaga gggtatggag catcacaagg
     5461 gtgttttgct gttgaatcaa ctataaatat gcttgctaat aaattaaaaa tggacccaac
     5521 agatttaagg ttaaaaaatg tggtaacaga aggtgaaact acatttgcat atggtaaaac
     5581 tttaaatagt gtcgatttaa taaaatgtat aaataaaggc aaagaactta ttggatggaa
     5641 tgaaaaatat ccttgtaaac atcttgataa tggaaaaatt agaagtgtgg gtatggcaat
     5701 tactatgcaa ggttctggta tacaaggtct tgataagtct tcagctgaaa taaaattgaa
     5761 tgactgtgga gattatactc ttatgatagg ttctactgat atgggtacag gaagtgatac
     5821 gattttagct caaatggctg ctgaggttct tgatacaagc attgaaaata taacagttat
     5881 atcagctgat actgacttag ttccatatga cccaggttca tatgcttcaa gtactactta
     5941 tgtaacaggt atggcagtag ttaaggcagc tcaagactta agagaaaaaa taatttctgc
     6001 tggagcaact aaactaggtg ttgagaagga tgaagtagaa tttgatggta taaaattaac
     6061 tagtaaaaaa ggtagcactt tattattcga tatagcagtt gattctacaa ttggtccaga
     6121 tactaatcaa ttaataggtc ttgcttctca tggtagccca gtatctcctc caccttttat
     6181 agcaggtttt gcagaaactg aaattgacac agaaactgga aaagttgatt tagtaaatta
     6241 tgtagctgta gtagattgtg gaacggttat aaataaaaat ctagctaaga tacaagttga
     6301 aggtggaatt gttcaaggga ttggaatgtc attatttgaa gaagttagat acacagaaaa
     6361 aggaagcatg gacacaaata catttatgca atacaagatt ccagctagat gtgatattgg
     6421 aaatgttaaa gtagattttg ttgaaactta tgaaccaact gggccatttg gtgctaaatc
     6481 tgttggagaa gttgttataa atacaccttt accagcaata caagaagctg tgtttaatgg
     6541 aattggtgta agaataaata cactccctat tacacctgaa aaagttttta tggaaatgaa
     6601 taaataatta tttatgaaaa tttagactag ttttacatgt taaacaacca gttatgtcat
     6661 acctgttgaa agatatttaa taagtagtta ttataatatt atgaatttta cttataaaat
     6721 acaaaattaa ataaggggat gatgttttgg ctggtaatct aaataatatg agagcagtaa
     6781 ataattttag aggagataag aacattttag aatgtttagt cagctttgag ggtcgttcaa
     6841 taagtcagag aaaagtaagg gtatttttta aagaaaaaca aaatcaaata gaaattgatt
     6901 ttgcagaaga ggaaatttct aaattggttg aaaatgttgt tttaaataca tcatatcaag
     6961 aaatgttata tgatgaaata gagaaacaac tggaaattga ttgtataggt acttggatga
     7021 tattatctaa attaaaagat ggtagtagag ttcactgatt ttaaaataaa ttattagagc
     7081 ctaattttaa ggctcttttt tgctgttttt aattaacaat agaaaattta tctttagttt
     7141 gtatataatt ttaatatcat atattctata tatataaaat tgaatttgta tgtattatat
     7201 tgtataatat aaaatgaatt gggaaaatag ttcgctaaaa taatttgttt ttataaaatt
     7261 actgtttaag tttatagatt ttgtataaaa taaagttatg ttattaattt ttttaaaaat
     7321 aaaactttta ctaggagaca gatatgagaa aaaatagtat taatatagca ctaactgcag
     7381 caattacagc aatctatgca gttttaacat tatcattggg atttataagt tatggaccaa
     7441 tacaatttag ggtagcagag attatgatgc ttttggcatt tttagataaa ggatatatag
     7501 taggtcttac attaggttgt tttttagcaa atgtaatagg accatatggt gtacctgata
     7561 taatttttgg aacattagcc acatttataa gtgcaagtat gatttatatt actagaaagt
     7621 taggtaaaca gaataaaagt actttagtta tagcttcttt atggccaact gttataaatt
     7681 cgattgtggt tggtctaatg ttaaatgtat tctttgggct tccattaatt ctatctatga
     7741 tacaggtagg ttttggagaa tttgtagtag taacaattgt aggagtacca tttttctgtt
     7801 ttttaatgaa aaaatataaa aatgtcatta atattaaatt ttaaatagtg tatagtaatt
     7861 taattaattg agagtattat tagtgaaaag aggtgtttat ttgtcgaagg taaaaagatt
     7921 gactgatgtt tggatatata ttaatgataa gcaaaagttt acaataaaag agttgtcaga
     7981 ggaatttaat ctttcagcca aaacaataca acgatattta aaagaattaa ataaaatggg
     8041 acttccaatt caagcagaac aaggtagaaa tggaggttat agggtgctaa ataatagcta
     8101 tatacctcct gttatattta cagaaaaaga agttatgatt atactatttg cacttaagtc
     8161 acttcagatt tataattata agttaatgga aatagaaatt aattctataa tgagaaaagt
     8221 aagttatgaa cgtaaaagca gtataaaagt aggtatagaa aatattaaaa gatacattgg
     8281 ctttgtagct aatgatacta atgatggaga ttttaagagt agtaatgtaa ctgagttttt
     8341 tagagcttct tcagaatctc taattttaaa tattaagtat aagtgtggta atcagatttt
     8401 ggaaaaaaac gtatgcccta taggtatata tttaaataag ggagcatggt tttcaccagc
     8461 atatgattgt aaaagtgata aaataatatt agttcatata gataatataa ttgatataaa
     8521 aagaacagga gaaagtaaaa aaatacatat aaacttggaa gaatggttac atgaagtata
     8581 taacaattta tatggaaata gttcaactac taaaaaattt ggtgaaatta tttatctaaa
     8641 tgtattatta actaaagaag gtgtttctaa aataaaggac agttcttgga atttagatat
     8701 ggagctaaat gaagatggta gtggaataat tagtacattc ataaaggttg aagatataga
     8761 ttgttatgct tcgattttat tttttattgg aaataatgct aaggttatag agccaaaatt
     8821 tttgaataag ctactttatg ataaggccaa tgagttaaga tatttttatg aagaaaatat
     8881 ggtataatat ttagaaatgt tgaaattaaa taattattaa ggagatatac gttataatgg
     8941 aaaattttaa taagaatgct aaaataattg gtattggagc tgaaggtatt aatataataa
     9001 atgaagtaga agaaaaaata aaagcaaata tggatataga aaaaataaac ataaatcaag
     9061 agattgaaaa agaatatgtt agaagtcttt tagatggtgt agatatatta tttttgatat
     9121 attcatctga agataaacat attagagata ttataaaagc tgtttcatat atgtcaaacg
     9181 aaagaagagt tctatctata ggaatggatt gttcagagaa agaaaataaa gaagatttag
     9241 agcttgggag agagtttaaa atcaataatg atagtatatt taaatttgtt gatttaatga
     9301 atatcatggt agagtctatt tctgattctt gcatgataaa tatagatatt actgatttaa
     9361 aagaagctat tgtaggagat aaaggaatta agtattcttt tgaagagttt gaagatacaa
     9421 agtcatatag cgagatagct gacattttat ttgacaggat ggaatatatt ggtgaggaat
     9481 ttataagtaa gaaaggaatt gtatttgttg aaggaagtcc agaattttct ataatggaat
     9541 tgaatgattt aataagtaat attcagagca aggtagaaga aagctatgaa gtaatatttt
     9601 ctttatatat aaaggaaaat ttaaatggaa atattagagt aggcttattg tataattagt
     9661 atattttaga tattaaggag agtgtatatg tctgaaaata taagaggtac agagtattgg
     9721 ttaatggaag aattttttta tcaggaaaca gacacaccac agatttttag agaagaaagc
     9781 ataattgcac ttggatttga tataaaaata aatttaaaaa aagtattcag tatggggaaa
     9841 aaatcagaaa agtatattaa tgagaattgt aatgataaag attttataaa aaagtttatg
     9901 tcgattaaaa aaggagatta ttttttatat aaagcatatc aaaatataga agaaaaagtt
     9961 aaatgtaatg tgtctattgg catagttgaa gaagattttg aaaatggata tgaattaagt
    10021 catattttag ggcatacact accagtaaaa tggatgcata attttgatac agtttcaaat
    10081 tgtaaagtat atacaagtga attttataaa ttaaataata atgatattag ctcatattta
    10141 gaaattatta agtcacaaga taagaaatta ttgagaaaaa gaatagaaga aagtgaaaat
    10201 aataaatggt atttaaaaaa ctattattat aaaaatgtag ataagtgtgt agatgatgaa
    10261 gaattattta ttcagcccat taatctagaa caattagaaa gtctaaaaaa tataaagaca
    10321 gatgattata ttttattgta taatagcgag aaagtaattt gtgaaaatga ccatacaatg
    10381 aagagtctat ttggcgtatg tcaagttatg gaagggttcg ataaagagaa agtaagtgct
    10441 ttggagggtg gatatttttt tcctgttaga tggatagagt atgaaaagga gaatatagac
    10501 ggaaatgcat gggttatatt tgaaaataat agtatagttg aaaagtatgt aaaaagattt
    10561 actaataaaa tgccattaaa tactatactt tatggaccac caggaactgg taaaacatac
    10621 aatacaaaac agatggttta caatctagta agtgaaacca gtctaagaaa cagatactat
    10681 acaggttact tagattataa aaacaatgta gaattttgta catttcatca atcatatgga
    10741 tatgaggaat ttatagaggg tcttaagtct gatggtgaag gcaattttaa gccagaagat
    10801 gggatattaa aggatatatc tatagaagca tgttataatg cattgaaatt tgaaaaaaag
    10861 atgagctttg agttggaaaa agatagcttg actttagaaa ctataaaaga caggaaaaag
    10921 aaattagtat tagaaaatat agaatatagt gagagtttta attttgaaga atcagaaaac
    10981 tatgttttaa taatagatga aattaataga gggaatgtat ctaaaatatt tggtgagcta
    11041 ataacattat tggaagatga taaaagactt actaaatcaa atcaaactat tgtcaaacta
    11101 ccatattcaa aggaaaaatt ttctctacct ccaaatttgt atatagttgg aactatgaac
    11161 acatcagata aatcaatagc acttttagat atagctttaa gaagaaggtt taattttgaa
    11221 gaaattatgc cagattatga tttattgtct attgtagatg gtatagatat tagaaaaatg
    11281 ctatatacaa tcaataaaag gatagagttt ttatatgata gagaccatgt tattggacaa
    11341 gcttatctac ttgctgtaga aaatattaat gatatagtag tagtatttag aagtaaaata
    11401 ataccacttc ttcaagagta tttttattat gattcagaaa aagtaggttt gattttagga
    11461 ggaattggaa gaaatgaaaa agataaatac attgtttata aagaaaaact tatagcttct
    11521 gagttattta aaaataataa tgcctcaata atggagagta aagttaacta ttgtataaaa
    11581 caaaacatat ctagtgagga gctaaaaaat atatatgagt aaaaatatat atgttaagga
    11641 aacctatgaa tggataagga taggtaatgg tgaaaatgag cttacagaaa ttgaatatga
    11701 aaaattgctt aagtatctag agaacaataa tgatgtatta aaaagtaata taatagatat
    11761 taaatacaaa aaacttagat ttataaacta tgtaggcatc atatgttttg aaaatgtaat
    11821 acttgaaata cttcctaaat tgtcattaag tgataatctt gtaaaagata gagagatact
    11881 attacagatg ctttctatat gtaataaaat tccaattaca atgaatgaaa aaataagatt
    11941 gagtttgaaa aattataatc tcttaaattt ttttgttatg tatttcattg agagtatgca
    12001 aacacagatg aaaaaaggta tttattttga atatataaat aaaatagaga acttaaatgt
    12061 tatgaggggt aaaatattat taagtacata tgcaaaagaa aaaggcattt ctccaatgaa
    12121 aataagatgt gaatatgatg agtatagtga aaataatttc ttgaatcaag ttcttaaaaa
    12181 agcatgtata tctattttat gtagaataaa tgacaattca attcaaggca agattaaaaa
    12241 aattttaagc tattttcaaa atgtagattt aatttatata gatagaaaaa aactattgga
    12301 ttataaattt tataaaaaca atgatagatt taaagattgt tatttactag ctagacttct
    12361 acttttaaat ttgtctatgg ataatagtca aaataatcaa gaggcatttt ctatattatt
    12421 tgaaataaat actttgtatg aagaatatat aggaatttta atcaaaagta tatgggacaa
    12481 ttcatttaga gaaacatata tacaagataa gagtaaattt cttttgaaaa atgaacaaac
    12541 aggtaagaaa aactttaatt taagaccgga tatagtttta tatgacttaa aaaatgaata
    12601 tgaaattata attgacacta aatggaaagc tattgaagta gattcaaatg ttttttatag
    12661 gtcaagtgat atataccaga tgtatgcata tataacagca tatgaaaatg caaaaagatg
    12721 tatattatta tatccttgta ttcaaaaaga taagaattat agttcctgga aattatcaga
    12781 atcatttaag ggtaagttta tagaagcaaa aactgtgagg ttagatgata taaaaaacac
    12841 aaaaaatgat ttaaaaaaga taatttttaa ttataaattt taaaaataag aattttaaaa
    12901 tttataaaag taattttata taggtataaa aattacgagt agtataaaaa atttaataag
    12961 gatttaaatt aaaaatttta aaaattattt ccatataaaa tatggcattg taattgctta
    13021 tttaatagag catttttgta aaatgaagaa agtatatcta tcaaattaaa actaagtaga
    13081 tatacttttt attaagtttt gttttaaaat aatattatta aattataact aagcttttct
    13141 gttatgatat aattaaatag ataatgtgaa tgattattat atagaatact tatttggagt
    13201 tgatatttta tggacaaaca cagtgattca gtaatgtatg gtggaatgga agtatataat
    13261 atttggggaa caacaacagt agactccata attggagagt ctgatgtaat gcgtgctctt
    13321 aagaatagaa tttgtaaaat tggaaatagt gattctactg tagctataac tggagaaagt
    13381 ggcactggaa aagaattaat agcaagagcc attcatctcg caggaaacag agggaataaa
    13441 acattcgttg ctataaactg tgctgctata ccagaacctt tactagaaag tgaacttttt
    13501 ggatatacaa aaggagcttt tagtggagca gattcaaaag gtaaaattgg taagtttgaa
    13561 ttggccaatg gaggggttgt atttttagat gagataggag atatgccaat tcaactacaa
    13621 tcaaagttat tgagggtatt acaggaaaag aagtttacga gaataggttc aaatgaacta
    13681 attgatatag atgttagaat catatcagct actaatagag atttatttga gttggttaag
    13741 gaaaataaat ttagagaaga cttatactat agattgaatg taataccttt agaagtgcct
    13801 ccacttagag aaagaggaga cgatatacaa atattaataa acaattttat agacaaatat
    13861 tcgagaaaga tgaagaaaaa cgtgtaccat atagagccag atgtggaaca aatgttgctt
    13921 aagtatcctt ggccaggaaa tattagagag ttggaaaata ctatagaact ggcattaaac
    13981 cttcttgagg aagatggaat aatacataaa ggaataataa atagaaagat acttgaatat
    14041 tttaagttaa ataatataaa tataaagtta cttgaggaaa gtgactatga gataagtatg
    14101 gaacaagaca tacttacact tgaagagttt gaaagagcct atataaagaa agtgttaaag
    14161 ttttacggaa atgatactaa gtctaaaaaa ctggctgcca aaaaacttgg aatatcacta
    14221 gctacattgt acagaaaaat agatgtataa taattaggct ttttattctc aattctaaaa
    14281 tttgaaatta taaaattgat aaaaaacact tggaaaacta ttttctaagt gtttttttgt
    14341 gtaatagcat tttattatcc aaaaataaaa aaaatttaaa agaatttaaa aaaataaatg
    14401 ctttaataaa ttatcaaata ctaacaaata taataaaaat tatatatgta aaacaattat
    14461 gttaaaaaat tggcattata attgcttcat attaagttga gatgacaaaa taaaaaaaga
    14521 aaggatgttg tgtgagataa taataactgt cattaaaaat agttgggagt gataaccttg
    14581 agtaaatatc aaaagaatgt ttctatgttt gatattgatg gaaggccacc aattttaaag
    14641 tgtttgccac tatcaatgca acatatacta gcaatgatag ttggaactgt tacagtacct
    14701 atagtcgtag gaggagctgt gggtgttagc cctacacaaa taacactttt agtgcaatat
    14761 gcattaataa tagctggtat atcaacactt atacaactat atccaatagg aaatattggt
    14821 tcaagattgc ctataatttt tggagttggt tttacttatg taccaacact tgtagcagtc
    14881 ggaggaaatt atggattagc aagcattttg ggtgcacaat taataggggg agtggctaca
    14941 gtattaatag ggatattcat aaaaaagata agaaaatttt ttccgaatat agttgcagga
    15001 acagtggttt ttacaattgg attatctttg tatcctatag caataaatta tatggcaggt
    15061 ggtgtaaata gtcctactta tgcctctatg caaaactggg cagtagcggc tataacatta
    15121 gtggtagtta taggtcttag tcaatttgca aaaggatatg caaaattggc agcaatattt
    15181 ttgggaatta tagttggata ttgtgtatct ttagttctgg gtataataaa ttttgaccct
    15241 attagagagg caacttggtt tgcgatacct aaaccgcttg aatttgggat ggaatttgat
    15301 atgcctgtaa taatctcagt agtaattgta agtataatca atgctgttca agcaattgga
    15361 gacttatcag ctactacaat gggaggcatg gataggaata tcacagataa ggaattatca
    15421 agtggagtaa taggaagtgg aatttgtact atgataggag ctttgtttgg aggtttacca
    15481 tcatcatata gccaaaacgt ggggatggta gctatgaaca aagtaataag tagatttgtg
    15541 cttggaatag ctggtatatt tatgttattg tcggggtttg tgcctaaatt tggtgcatta
    15601 atgactacta taccatattc tgttttagga ggagctacaa tatctatatt tagtatgata
    15661 acaatgacag gtataaagtt aattattaca gaagagttgt catcaagaaa tattaccatt
    15721 gttggtttgg caattgcctt aggcatggga ataacatcag tcccagcagc ccaagaggca
    15781 tttccttcat ttgtaaagtt agtatttgga gaatctccaa tagtaattgc aacattggtt
    15841 gcattcgttt taaatctaat aataccaaat aaaagtctag aggatgaggc taaagaaaga
    15901 gctgttatgg aagagactaa ttaagatata ataatttaaa agaattgttt aaattattta
    15961 gtatgagatt gttagattat ttttgatagc tattcatttt aataaaaaat ttaacaaata
    16021 aatatatacc aggcaattaa tgttcattta agttgaaaat cggggaggca atatttagaa
    16081 atttgttaat tttttataaa aatagctcag tttagctgtg tttatcggtt gagcaataaa
    16141 ttcatggtca taaaaatatt tatagaaaat aattataaaa atatttagtc aagatattta
    16201 tgtatgggag gatttatttt atgaaaacac gtaatacttc aaaatatgat gtcgatggga
    16261 taccaccact aaaggaatca atacctttgg ccttacaaca tctgttagca atgatagtag
    16321 gaaatatggt acctgcgata ttaatagcaa acgtggtagg acttaaccag gggcaagcaa
    16381 caatgttgat tcagggttct atgttagcag caggtttagc aacgttttta cagttatatc
    16441 caataccttt atttaaagga tttaagttag gttcaagatt acctgtaatg atgggaatga
    16501 gttatgtatt tttaggagct tgtctttcag tagcagctaa agatggttta gcagctctat
    16561 ttggagcaca gattgctgct ggggtaatcg tattctttgt aggatttgga gttaagaaaa
    16621 ttagacatat attcactcca atagtttctg gaactataat agcatgtatg ggacttggac
    16681 tattcgcaac agctataaag aatttagctg gaggagaagg cacacaaaca tttggaagcc
    16741 caataaactt cacagtagga gttatagttg cttttgtaat aataatgata aataaatacg
    16801 gtaaaggttt agtaaaaaat tcttcaatat taataggaat attagtaggt tatgctatat
    16861 ctttagtttt aggattggtt gatttctcag ccgttcaagg agcagctata gtatctttac
    16921 caacaccagc agcttttgga ttagaattta gaccagagtt aatagtaatg tttactatta
    16981 tttacataat aggtatagct gatatgatgg gtgcctgtac aatagctaca gtaggagcaa
    17041 tggatagaga ggtaactgac gaagaattag catcagttgt attaggaaat tctataactt
    17101 ctataatttc atcactattt gcagctcttc caactggagt atttagccaa aatacagtaa
    17161 ttgtatctat gaacaaagtt acaagtagat ttgtaatagc actaggggca cttgtattat
    17221 tactagcagg gatatctcca gcattgggtg caataatgac aactatacca tcttgtgttg
    17281 ttggtggagc aactttagta gttttctcat caatagcaat gtctggtttc tctattatga
    17341 gtatggatgg attcactgaa gaaaacaatc ttatagcagg tgtatctata gcaacaagta
    17401 tgggtcttac aactgctcca caagttttag accaattccc agaaacaatt ggaactgtcc
    17461 ttggagggtc aagtatagtt tctggagcaa taatagctat attacttcaa acattattta
    17521 aattaaagtc acgtaaaagt gctgaaaacg ttacttcaaa tcttgaggaa aatattggat
    17581 aaatgtatta gatataatat gagaaaacca tatggtaaaa tgttgtaatg aaagtattca
    17641 aagggggatt taagatgatt gatatactaa taaaaaatgc aataattgtt acagttaata
    17701 aagacagaga tgttatattt gatggagcaa tagctattca aggtgacaga atcttggaca
    17761 taggaaatac agttgatatt gagcctaagt atcttgatgc taaaaaagtt atagatgcta
    17821 atggaaaagt aatattccct ggctttataa atactcataa tcacctgttc caagtgttat
    17881 taaaaggttt aggtgatgat atggcacttc atgagtggtt aaatacaatg atgtttccat
    17941 cagcaaaatt cttaacagaa caagatactt atgatgctgc aatgcttgga tgtatggaag
    18001 gtttaaaaag tggtataact acaatggttg attatatgca tactcacaat agaccaggac
    18061 ttacagatgg aatagtaaag gcatataaag atttaggtat aagaggggtt gtaggtagag
    18121 gttgtataga tttaggtatt cacaaagagc ttatagaaga tgtggaaacg gttgaaaaag
    18181 atttgagaag ggtattcgaa aaatatcata attcagaaaa tggaagaata aaaatctgcg
    18241 tagctccttc ttcaatgtgg gctatatctg aagaaatggg taagatgctt tggaatatag
    18301 ttaaagaata tgattcatat tttacagttc atatatctga aacagaattt gcaagaacag
    18361 caacaaagga tatacatgga gaaatagata taaaattact tgaaaaatgg ggtatagtag
    18421 gtccagaagt tgtagcagta cattgtgtat gtataactga tgaagacatg gaaatgctta
    18481 aaaagtatga cataaaagtt tctcataatg tagcaagtaa catgtatctt gcttctggtg
    18541 ttgcacctgt gccagaaatg ttaaaaaaag gtataaatgt gagtttaggt cttgacggtg
    18601 cagcaagtaa taacgcacaa gatatggtag agcttatgaa attaacagct ttacaacaca
    18661 aagtaaataa ttgtgaccct ctggcaattt ctgcagagaa agttcttgaa atggctacaa
    18721 ttgagggagc aagaactctt agaatggaag atgaaatagg ttctttggag attgggaaaa
    18781 aagctgacct agtaatattt aactcaatgc tttctccaaa atcaatacct cttcacaatc
    18841 ctgtatcaac tttggtatac tcagctagta tgcacaatgt agagagtgtt ttagttgatg
    18901 gaaatgtaat acttgaaaat ggaaaagtaa ctacaattga aagtgaagaa caagtgttgc
    18961 ttaatgcaca acatgcagca gaagaattat gtaagagagc taatgtaact aatagaatgg
    19021 aaggacataa gtggaatagc ttatactaat attaaaataa gattgtaata atattctatt
    19081 acaacattag tttatctgta ggaggagaaa atggaaaaaa taaaattaaa tattaatgat
    19141 tacatgtatg aaatagaagt tgaaaagaat gaaactcttt tgcatgtact tcgtgaaaaa
    19201 ttaaatctaa ctggagcgaa acaaggttgt aatagtggca gttgtggagc atgtaaagtt
    19261 ttgatagatg gagttgacat gaaatcttgt aaacttcttg caaaaaactg cgaaggtaaa
    19321 gttatataca ctatagaaag ttttgctaat ggagaaaatc ttcatccaat acaagaagct
    19381 tttatagaag tcggagctgt acaatgtgga tattgtactc ctggtatgat tataacaaca
    19441 caagctcttt taaatagaaa tgcatctcct aatgaagatg aaattagaga agcttttaaa
    19501 gaaaatctct gtagatgcac aggatatgta aagattatag aagctgtaaa attatctgca
    19561 gctagattag ggggtagata attatggaaa aggtaatagg aaaatcatac cctctaaaag
    19621 atgcagcttt aaaagttact ggtcaaatga aatacgtggc tgatatgaaa ccacaaaatg
    19681 tactttacgc taagatgctt ttaagccctg tagcacatgc aaaaataaaa agtatagata
    19741 caagtgaagc tgagaaagta gtaggtgtta gagctatagc tacttatctc aatacatcac
    19801 aaagaaaata caatggttca ttaagatttt atgagcacaa aatacctgaa aatgaagtta
    19861 tattttcaga tacagttaga tttgttggtg accgtgttgc agcagtagct gcagagactc
    19921 cagaaatagc agagaaagct gtaaaactta taaaagttga atatgaagaa ttgccagctg
    19981 tatttactat acaagatgca ataaaagaag atgctatctg catacatgga gattcaaata
    20041 tagtttctca aaacaacata aatgggggag atgtagaaaa aggcttcaag gaatgtgatt
    20101 atatatttga agatgaatac tctactccag caatacatca tagtgcaata gagactcata
    20161 gtgtaattgc acactatgat tataatgata aattaactgt acatacacct tgccaaaata
    20221 catttggatt tagaataata ctatctcaaa tttttgggat gtcattaaat aaagtaagag
    20281 ttataagacc tgctattgga ggctcatttg gtggaaaatt agaacttaca attgaaccag
    20341 tagcagccgc attatcaaaa atgacaagaa gaccagttaa aatggttctt acaagaaagg
    20401 aatctatgat atcaacaaga actcgtcatg ggtcttttgt aaaattaaaa actggtgtaa
    20461 ataaagatgg tgaagtaata gcacaagaca taaaaatata tacaaataca ggagcatatg
    20521 catcaagtgc tttaaatgtt ataggagcac ttagtcataa agtatttaaa gtttataaaa
    20581 taccaaatat aaagtttact gggatgcctg tatatacaaa tacaccaata gcaggagcta
    20641 tgagaggcta tgggtcacct caaatattta tggctcaaca agctcaattt gcgaaaatag
    20701 caaaggaaat aggtatggat ttagtcgatt ttcaaaataa aaatgcagta gagccagatg
    20761 atgtcgatat aatcttccac ggttctcttg gaaatcctag agtattggat tgtatagagc
    20821 aaggtaagaa gatgtttaag tgggatgaaa agaaaaaact tccaaaagaa gaaggaaaat
    20881 atttaagagg tataggtatg gcaataggtg cacatggtaa tggagttttt ggtgcacata
    20941 gagatgttgt tacattgact cttaaattaa atgaagatgg tacgttgaca ctactaacag
    21001 gagctcatga tatgggtaat ggtgttgtaa ctatgcaaac aatgatggta gctgaagttt
    21061 taggaataac acctgataaa gttgatacat ttgaaactga tacggatgca tgtacattca
    21121 accttggtga ctatgcaagt agaggggtat ttgtagaagg tggaggagct aaaaagacag
    21181 cagagaaatt gaaaaatctt atattagaag aagcagaaaa attacttgaa acatcaaaag
    21241 aagatttata cctagacaat ggatgtgtaa ttagtaaact tgatgaaaat gtaaaagcat
    21301 cactttctga tgtcgcagta tatagtcaaa gtaaatcatt aagagagtta actgttgttg
    21361 aagattattc ttcaccagct ggacgtactt cttatggtgt acattttgct gaagttttag
    21421 tagataaaga aactaaggat ataaaagtag ttgattttgt agctgtacat gatgttggta
    21481 gagttataaa tcctctaaat ttagaaggac aattagaagg tgggattcat atgggtctag
    21541 gatacgcatt gagtgaagaa ttggcatttg atgaacaagg tagacctaaa gctactgatt
    21601 ttaaaacata taaattattt agaactgtag atatgccaaa atgtcaagtt gcatttgtag
    21661 atggttatga aaaagctggg ccttttggtg gtaagagtat tggagaatgt gccgttgtac
    21721 cagttgcgcc agctgttgca aatgcagtat ataatgcaac tgatgtagag atacattcat
    21781 taccaataaa attaaaatag tagaaattaa agcagaaata acaatttatt gtatttgtaa
    21841 atagataata aaaatagatt tatttggtga ggagatatta ttatggcaaa gatattaggt
    21901 atttgtggaa gtccacgtaa aggagcaaca gaatatgcag tgttagaagc tttgaaagaa
    21961 gcagaaacta tacctggtat agaaactgag tattggtcag ttagagggaa aaaaataagt
    22021 ccttgtgtac attgtgatgc atgtataaga aaagaaacta tgtgtattat aaaagatgat
    22081 atccaagaat tagagcaaaa aatattggag gcagatggaa ttatagtagg ttctccagtt
    22141 tatgatatga atataactgc tcaacttaca gcagtattta atagacttcg tccaatgtat
    22201 ttagttcatc caggaaaact tcaaaataag gttggtgcag ctataactac tggtggaact
    22261 agatatggtg gccaagaatt gacaaaactt cctataataa atttcttcct aatgcatgaa
    22321 atgttagtgt ctggaggttt aggtggatgc tatataggtg gtacaatatg gagtaaagat
    22381 ggaaaagcaa aaggtgccca agaggatgag acaggtatgg acacagtaaa aagacttgga
    22441 aaaggtgcag cagaggcagt tatggtttct aagtttggtc ttgaaaaatg gaatgtcgta
    22501 aaagaagaat tagatgttaa aaaagatgaa aaatcacctc ttagagacca ctaaagattt
    22561 attatattat tgaatatata caaatagtga tgtaatagat tattgcatca ctattttatg
    22621 ttttaattta gattttataa attttatatt aaaaaatata gaaacaaagt gttttgagat
    22681 ttatttttaa attttaaaaa tgagaattaa aaagtgagaa gatagaaaag gttttttagt
    22741 tattaaattc tacatacatt gtatgaacta aagatagaaa agaaaaaata ataaaagcat
    22801 tgcaatttct atactaaaga gtcatggaaa aatatctagt atatatttag tattggcatg
    22861 ttaattgctt atatattaaa gtataaaaat ttaacaataa tttggaggta ttttagatgt
    22921 taaaagaaat taaatggaaa gtaaataatt tgccaaaggg cgataaggaa aattgtatca
    22981 aatttttaaa tgaagaagaa ataactaagg ttagaaattt tcacaaaagc tttcctcaat
    23041 ataaagaaac tccattagca aacctagaag gtttagcaaa aaaattaggt gttgcaggag
    23101 tatatgtaaa agatgaatct tatagatttg gattaaatgc atttaaagta ttaggtggtt
    23161 cttattctat gggtagatac ttagctcaaa gattagatac agatatatct gagttagggt
    23221 atgacaaatt gacttcgaaa gaaataaaag aaaaattagg agaaataact ttctttacag
    23281 ctacagatgg aaatca
//
LOCUS       DAEQCW010000057        23208 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.057, whole genome shotgun sequence.
ACCESSION   DAEQCW010000057 DAEQCW010000000
VERSION     DAEQCW010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23208)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23208)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23208
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.057"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(160..528)
                     /locus_tag="KRO40_002214"
     CDS             complement(160..528)
                     /locus_tag="KRO40_002214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093031.1"
                     /translation="MKKIPKSELLVMNFIWDKGIDKIPAREVANYMEISHGWTKGTTG
                     KVLSRLSDKGFLEFEKDGRNTLYTIKVKHEEYLKFETKDFLELIHKNSIHSFISSLGC
                     GNEISDDDIKELEQWLKKRK"
     gene            complement(1056..1478)
                     /locus_tag="KRO40_002215"
     CDS             complement(1056..1478)
                     /locus_tag="KRO40_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3284 domain-containing protein"
                     /protein_id="HBH2093032.1"
                     /translation="MNTFKTEVLLKYSAKDIFNIFTKSARLNFPNFNEKKAVGTFVQQ
                     KNNKRFKVEITNFEKNRVYEIKTSNKRESTITRYELVHIDLENTKLIFIESESKRNIF
                     GKINSALVRVLFGKRQPEEFNKFIKKLEMELENNSVNL"
     gene            1956..4859
                     /locus_tag="KRO40_002216"
     CDS             1956..4859
                     /locus_tag="KRO40_002216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093033.1"
                     /translation="MELRDKLVNIINTENKKDPLTDVQIAKFLSTTRENITNLRKELN
                     ISNSRQRRYPYLKSAISAILQKNKNISISEITRELMTEGFNISRRVVEELLPKESLEM
                     DVVEEDEEESNDPFETLIGNKGSLRNAVEQAKSAILYPPKGLPTLIIGESGVGKSLFS
                     RHMYEFAKQKKIVKESSNFVVFNCADYSDNPQLLLSLLFGYKKGAFTGAEYDTPGLVE
                     EADEGVLFLDEIHRLPPKGQEILFSILDRGKFRRLGETNAERKVSIMLIGATTENVET
                     NLLLTFRRRIPMLITLPPLHDRLLKEKIDLIYNIFQQECNRINAKIFVDKNVIEILAL
                     KKFSGNIGQLQNMIQVLCARAFMKFINSKDEDSESIVVVDINEVLKLKDSFKDAAFQE
                     IEYTEIRKYLKNAIFIPFNLEESSVKGSLLSDEYILPEDIYKTIEKKYYDLKSLDIED
                     IDIENILWTFILNRFADLKFNLDSNEEIFSMSDLNSFVSDSLVKLVKELMNDIVEKNM
                     NLEVNKNMFKYLAIHLEEAIKRIKLNQKIINVNLEKIKIDFSKEYEISKSFAIKIEES
                     IGIKISDDEIGFITLYIKSALKNEVKKDKVGLIIISHGRIATETVNVVKELLGVKFPV
                     AIDMPLDEKPINIYNKAVELSKIIDQGKGILFLVDIGSLTNIGQIVNKRTNISTKTID
                     RVDLLMALEATRKVSMGEEELDEIFFSLLKDRMGYNYELEKHIDKSNAIITLCLTGEG
                     TAKYISKTLEEKYDNTKCYQMSALDESLFCKIENLKETNNILAIVGTINPKIPGINFI
                     PYNKELFKNLDIYLSKSKQQDDRPIKSYERMLDEDLVIFEPDIYFKKDLLEYVCSILI
                     NKEYVEKDYLDSVLHREEMLPTYSKGAIGVPHGDSSTVNSTRFVFVKLKNPIDWGVGN
                     VNFIFMPVFQANDKEIVKNVLEILKDAEFMNNANKCFDKDAFRRIIFDKFKHL"
     gene            4892..5338
                     /locus_tag="KRO40_002217"
     CDS             4892..5338
                     /locus_tag="KRO40_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093034.1"
                     /translation="MNVDLISLGLESNDYESVIEELGSIMCKKEYVKETYINAVLERE
                     RTLPTGLDIGDMCVAIPHTDSKHVNESNVAVGILKNPVKFNSMIDPKDRLDVELVFLL
                     AVKNPDSQVKLLKDLMSVFQNIKLLKNIKNASTKEEVAKLLDFIEI"
     gene            5461..5763
                     /locus_tag="KRO40_002218"
     CDS             5461..5763
                     /locus_tag="KRO40_002218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2093035.1"
                     /translation="MKQFNVLSVCGSGTVTSSMVAGKLKEVLGNKGISITTTEARPTE
                     ALNLAQSGRFDFITFTSPLQTGDYGIPTINAFACLTGIGEEAFFEEVLTVIEGIDK"
     gene            5944..7350
                     /locus_tag="KRO40_002219"
     CDS             5944..7350
                     /locus_tag="KRO40_002219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH2093036.1"
                     /translation="MLEFMKSIIDTFGSAIIVPIIIFIIAKIFKVTTKKSFLSAVYAG
                     VALQGFTLILNSFTPVITPVINRMVESTGVNLPVFDVGWQATSLVAFSTSAGMIYLGL
                     GILLQTILFLIKWTDVFQPSDLWNNYSYMVWGAMVIGVTGNFPLGIACMVLLNLYSLL
                     ISELVAKRWSSYYRYPNCTIIAMHNVEASVFAVFADPIYNKLGLNKMKLNPKELEKKL
                     GFLGEPITLGLFLGMFIGILGNMTRINTMEAWGEIMKVGISTSAVMAIFPKVASMFAQ
                     AFAPITEAARKIMQKAGNREWYIAVNDAVGYGEPATLISGLILIPIMLVIAMVLPGNK
                     VLPVVDLLAIPYMVQGLVAIHNGNIPKVLVSGIIWFGLGLYVCTSTAPLFTDMATNIG
                     VAIPAGAMLITSFNILGKPLMGLVFFAFLSANPIYIGLSVVIYFVLWALFRKNKTSIL
                     DYLEKQALKNVEEEPVAV"
     gene            7694..8752
                     /locus_tag="KRO40_002220"
     CDS             7694..8752
                     /locus_tag="KRO40_002220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH2093037.1"
                     /translation="MGDKMRASVLYNVGDVRYEMVDIPEITDTQVLVNVKYVGICGSD
                     LPRSMVSGLSGNTKYPLILGHEFSGEVVKIGEKVKHINVGDRVAVAPLVPCGKCDYCN
                     EGNFGLCDDYNIIGTRVNGAFAEYVRVPEEHILKLPDTLDYETAAGIEPATIAYHGIS
                     KSNIRVGDSVVVLGCGPIGQFVIQWAKVFGASKIIAVDIFDEKLELSKLLGANYILNS
                     KEVNVIKEIKKITNGGADVVIETAGSRFTQEQSLFVAKKRGNIVFVGISHTELPLSAD
                     ATECILRGELTLKGSWNSYTSPYPGRAWTATLDFMGKGDIIFKPMISHKIGLNEVGDF
                     LSKMSKREINFNKILVEI"
     gene            8851..9537
                     /gene="araD"
                     /locus_tag="KRO40_002221"
     CDS             8851..9537
                     /gene="araD"
                     /locus_tag="KRO40_002221"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HBH2093038.1"
                     /translation="MLENLKEEVLKANLELPKKKLITYTWGNVSGIDREKGLVVIKPS
                     GVEYSNMTVEDMVVVDLEGNIVDGKLRPSSDTPTHLVLYKEFEELGGIVHTHSSWATI
                     WAQIGKSIPSCGTTHADYFYGSIPCTRKMTREEIRNEYEKETGNVIIEEFMGRNPIHC
                     PGIIVNDHGPFTWGKDANEAVHNAVVLEEVAKMAYYTELMSPDNIMDKVLMNKHFSRK
                     HGKNAYYGQK"
     gene            9555..10202
                     /locus_tag="KRO40_002222"
     CDS             9555..10202
                     /locus_tag="KRO40_002222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBH2093039.1"
                     /translation="MLDSLKGKVVEIAIKAEHYGLCKEKTGNFSIRDKDTGYILITPS
                     GVGREELKVEHICVLDLDGNVIEVEKGIKPSSEVLMHIEIYKTRENINAISHTHSLYA
                     TAFSVAKKPIIPIVYESVNYGGYVDIAPYERPGTLKLAKSVSKLLIDTDACLLERHGL
                     TTVGNDLDEALLKSRYVEEVAEIYYRSLVLNQFKELEVVDVDEFKSWKYPEEIKF"
     gene            complement(10375..11742)
                     /locus_tag="KRO40_002223"
     CDS             complement(10375..11742)
                     /locus_tag="KRO40_002223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HBH2093040.1"
                     /translation="MNLIDILNKVDAFIWGPPLLVLLVGTGILLTVKLGVVQITKLPR
                     ALKLIFSAENKGSGDVSSFAALCTALAATVGTGNIVGVATAIKAGGPGALFWMWIAAF
                     FGMATKYSEGVLAIKYRTKDKNGQVSGGPMYYIVNGMGEKWRPLAIFFAISGILVALL
                     GIGTFTQVNSITDAINNSFGIDPRITGVVLAVFVALVVFGGLKSISNVATKIVPFMAV
                     IYVVICGIILISFWNKIPETFMLIIKSAFTPTAATGGFLGATMSLAIRNGIARGVFSN
                     ESGLGSAPIAAAAAKTEWPAEQGLISMTGTFIDTIIICTLTGFSLVISGVWCSDLNGA
                     VMTQAAFNGAIPTFGPILLTVSLTLFAFTTILGWSYYGERCFEFLFGVKGMNGYRTVF
                     VAMVLLGAFLKLEVVWIIADIVNGLMAIPNLIALLALSPIIVSETKKYFEHINSPENQ
                     IKKNA"
     regulatory      complement(11932..12020)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            12448..14568
                     /locus_tag="KRO40_002224"
     CDS             12448..14568
                     /locus_tag="KRO40_002224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase III"
                     /protein_id="HBH2093041.1"
                     /translation="MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGH
                     LVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVI
                     ATDAGREGELVARWIIEKSQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSA
                     IARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLE
                     LIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPAL
                     YDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIK
                     AVNISDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYN
                     LVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESI
                     PNVLEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSF
                     LMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKD
                     YSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTIS
                     QVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYL
                     KNQNKNQETFNNPFAEALAKLKNK"
     gene            14672..15925
                     /locus_tag="KRO40_002225"
     CDS             14672..15925
                     /locus_tag="KRO40_002225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliS"
                     /protein_id="HBH2093042.1"
                     /translation="MDLSGIFKYYCKECENTWNNSSVELFENIETYSKDSQKKREKEL
                     DKLLNTISVHLERYPSDAVLRKMWVKKGEVFLQKTLEKENIFKLEKMDVEDRKKFLDI
                     TKQFIRDARKFDDDLPIGDIMQAMRNVWISNALQLLFGKEVYYSKANFAYSMLYPYTD
                     NYLDNTNIDKNDKILFNNWLEKRLLGEHIKSKDYHESKVSQMIDYIESVYPREKFTEV
                     YESLLLIFKSQVNSLKQHGKENHLCKEDLLSISIEKGGSSVLVDGYLISGLMTKEEIE
                     FCIGYGFLLQISDDLQDIKEDLKYNHKTIITEMSKEGTLDKVVNKLINFTIELIDSFK
                     INNKNKSVITMIKNDCLMLILFSVVYNAEFFSVGYIKEVEKFIPYTIDYSLEIEEKIK
                     EKFKNIDVLNNENEYKEMIDIICAE"
     gene            complement(16079..17140)
                     /gene="ytvI"
                     /locus_tag="KRO40_002226"
     CDS             complement(16079..17140)
                     /gene="ytvI"
                     /locus_tag="KRO40_002226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBH2093043.1"
                     /translation="MDIQKQKNFIIKFTYVVLITSIVYIVLKFLLPLLMPFVISFIIA
                     SILRPIIRLITNNTNLNRTLISIVILLIFYGLCIFLLVSFGVKIFASVSDVFFRLPEI
                     YKSSIQPTLNTLFSKIDASTPNVNLALILGWDNISQSMMSLVASISTNALNAIASIAS
                     KTPAFMLKLIITLIASFFFTFDYQKIVNFILKQFPEKSQFMIINIKNSSINALLKLLK
                     AYAILLSVTFIELLIGLTILKVENAFTISVIIALVDILPVLGTGSILTPWMIISLING
                     NINLAIGLLILYIIITVVRQILEPKVVGHQIGLYPLITLMCMFVGAQLFGIAGLFGFP
                     IAATIIKNLHDNGIITAFK"
     gene            17414..18154
                     /locus_tag="KRO40_002227"
     CDS             17414..18154
                     /locus_tag="KRO40_002227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HBH2093044.1"
                     /translation="MKNFRDLGGNKTEDGRTVKKGLFYRSAKLSNLSENDIKILRELN
                     IKYIFDYRSDEEARKHPSTIISNIKNIRIPAMRELEESGGSFGSIEDMIDGLFEKDGA
                     FNMLNNSYYNLPINNPSYKKLVELIRDYSNLPILNHCTAGKDRTGVGSAIILMILGVS
                     RENIMKDYLKSNDFADKEIERFIEYKPKFKDIPKENLKYIFGVNEEYMKTAFRRIDEE
                     YISVEAYLYGEFNLNKEEIRKLRNQYLE"
     gene            18166..19944
                     /locus_tag="KRO40_002228"
     CDS             18166..19944
                     /locus_tag="KRO40_002228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2093045.1"
                     /translation="MSLNITARQINIIKILLNSKDTISGIALSQEIGCSSKTIQNEIK
                     DINKQLRNGKILSIRGVGYKLEGSFDEVNLNSNLYDDVDRVEYIIRKILTLSNEEKNT
                     IKLEDLADSMYVSVSTVKNDLKEVKRMLEKYSISVKSKHKQGICVLESEDKILNCIVD
                     LSNKRDNQLSLNDFLNDDIKERKLLIKKLLLDILNENGLVLTDIEFKSVLNNILVMLS
                     RHKYNEKEFIENYIENYRSKRSSILENEQNKEIIINSIKTFCKNLKLATSIDISNDKV
                     FEEFLYKHISSLCKKIKLGINQSPIMAQDIKIKYPFAFELANIAKKTIEKDLKIEINE
                     DEVANIALHIGGAVERASYNNKDKVFKTIIVCTSGIGTSMLIKAKLENIFKEKLEILK
                     IIPSYLVEYIKVIDVDFVISTVPIEVGDVPVINISPILSEKEIRLIEKYIETGNIYLD
                     LDIKSLFDSELFFTDLVFKRKEEVIDFMASKLVQKGYIDEDMKKSYFEREKIATTEIG
                     NMVTIPHGAIGKIFDNKIAIGILKKPISWEISDVRLIIMLALDKDKILDYEVIFSKIY
                     KRVDSIAKVISICENSSFEKFVNLFN"
     gene            20111..21028
                     /gene="pfkB"
                     /locus_tag="KRO40_002229"
     CDS             20111..21028
                     /gene="pfkB"
                     /locus_tag="KRO40_002229"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBH2093046.1"
                     /translation="MIYTVTLNPSIDYIVKLDELKTGSTNRVKEEYVYPGGKGINVSR
                     ILKELGNDNTSLGFISGFTGEYIIRTLEEKELKTDFIKIKSGFSRINVKIKALKETEI
                     NGQGPNIDDEDIDTLYKKLDKLNQDDILILAGSIPSTLDEKLYENIMARLEKKNIKVV
                     VDATKNLLLNVLKYKPFLIKPNNDELEELFGVKLNSIEDMVKYARRLKEMGAINVLVS
                     MGKDGALLITEEDEVLISDVPKGKVKNSVGAGDSMVAGFISGYLNTGKYDYALKLGAA
                     SGSATAFSYDLAKREYIDKLVNEISVKQF"
     gene            21065..22984
                     /locus_tag="KRO40_002230"
     CDS             21065..22984
                     /locus_tag="KRO40_002230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093047.1"
                     /translation="MKIIDLLDEKSIKLNLNSKTKSEAIEELVDLVANSGNLNDKENY
                     KKAILAREEMSTTGIGEGVAIPHAKNSSVTKACIAAAVSKEGIDYESFDGSLSNLFFM
                     IAAPDGANNTHLEVLSRLSTILMDEDFRNKLINSSSEKEFKEIIDKKEREKFSEEYQD
                     EKVTEKNIIDTKENDANKYPKVLAVTACPTGIAHTFMAAESLNKMAENKGVSIKVETN
                     GSAGVKNKLTKDEIENATCIIVAADKNVEMARFNGKKVIKTKVADGIHKAEELIDKAV
                     NGDAPIYHGGDGSHNESNEESESGFRKVYKHLMNGVSNMLPFVIGGGILIAIAFLLDD
                     YTINPSNFGSNTPIAAFFKGIGDKAFGFMLPVLAGYIAYSISDRPAFVVGFVGGALAG
                     DGGSGFLGALLAGFIAGYLVEGLKKIFSVLPASLEGIKPVLLYPLLGTLLMGIIMTFL
                     VIPPVTAINNAMVGFLNGLGGTSKIVLGLVLGGMMAVDMGGPVNKAAYVFGVASLESG
                     QFEIMAAVMAGGMVPPLAIALATTFFKNRFTKEERDSGKVNYVMGLSFVTEGAIPFAA
                     GDPLHVIPACVGGSAVAGALSMLFNAALRAPHGGVFVIPVVTHPFAYILAIAVGALVG
                     MMLLALLKKPLNQEV"
BASE COUNT         9249 a         2510 c         3928 g         7521 t
ORIGIN      
        1 aaacatcatt ctgactacta ttaaaagaca tataaaataa ttaaacttaa aagtatattt
       61 gcttatcttt ttagtaaata aaatgaaaaa aagaattagt ggacttatgt aaatattaaa
      121 tttaataact tctataaata attccataaa atacgtctcc tattttcttt tttttagcca
      181 ttgttcaagt tcttttatgt catcatctga tatttcattt ccacaaccta atgatgatat
      241 aaagctatga atagaatttt tatgtataag ctctaaaaaa tcctttgttt caaattttag
      301 atattcctca tgtttaactt taatagtgta taaagtattt ctaccatctt tttcaaattc
      361 taaaaaacct ttatcactta atctagaaag tactttacca gtagtacctt ttgtccatcc
      421 atgagaaatt tccatataat tagctacttc tctggctggt attttatcta tgcctttatc
      481 ccatatgaaa ttcataacta acaactcgga ttttggtatt tttttcaata taatcactca
      541 cctttaactt gattatatta gacaaatgtc taatagtcaa tataatatat catcatgtat
      601 aaataatctt tatattattt tatgcttgag aactaagtag tatagattta tagataaaaa
      661 agatattgag agttttatgg aagaggggaa tatattttct attagagata agaatatgac
      721 atatattttt tattgatttg tacaaaaata ctatatagtg aataaattaa tatcttttct
      781 aaattagaag aggagaatct tattagataa agattatcct ctttattgaa agtttaaggg
      841 atattagaga ttattaattt ttctctcttt ttttaactaa aagcaataat acataaaatt
      901 attattgcta atgatactct taatgtggta tatagtcata gtgtcacatg tttatcaata
      961 gttttttcat taattattgt aacgaatagt aggactcata aaatacttag aaatatgttt
     1021 ttagatagat tttaaatata taatctaact tatatctata aattaacact attattctcc
     1081 aattccattt ctagtttttt tataaattta ttaaattctt ctggttgcct ttttccaaac
     1141 aatactctta caagagctga attgattttt ccaaatatat tcctcttgct ctcactttca
     1201 ataaaaataa gttttgtatt ttctaagtca atatgtacta attcatatct agtaatagta
     1261 ctttctcttt tattgcttgt ttttatctca tatactctat ttttttcgaa attagttatt
     1321 tcaaccttaa atcttttatt atttttttgc tgtacaaatg ttcctactgc ttttttctca
     1381 ttaaaattag gaaaatttag tcttgcagat tttgtaaata tattaaatat gtcttttgca
     1441 gaatatttta ataaaacttc agttttaaat gtattcatat cgttttccct tctgtatata
     1501 aatttaatat ttataagtta atttttaagt taaaatagta taatatgcca tattaaatca
     1561 tgttaaaact atttatatag ctaaaatctt acctatataa gtatgtatac tatcatataa
     1621 aaataaaatc ttaaaataga aagggttaaa aacacagttt attataattt ttattgttga
     1681 gtagatacgt actattatat atgattgagc aagtttttca atcataaatt tataaagtat
     1741 tttgcattaa aatttaaaca aagaattaaa ttatttaaga ttatgaataa ctaatacatt
     1801 tagtaaatta ctaaatatac aaaatgtaaa tacttatcaa aatgtataaa tacttatgac
     1861 atctagttac ttacagggtt taagtagaaa aaaatatcaa agtaagtatg gcatgatagt
     1921 tgcttatata tttatcaaga aaggagttat taagcatgga gttgagagat aaacttgtaa
     1981 acatcataaa tacagaaaat aaaaaagatc cattaacaga tgttcaaata gcaaagtttt
     2041 taagtacaac tagagagaac ataactaatt tgagaaaaga acttaatata agtaattcaa
     2101 ggcaaagaag atatccttat ttaaaatcag caatttcggc aatattacaa aagaataaga
     2161 atatttctat atcagaaatt acaagggaat tgatgacaga aggctttaat atatcgagaa
     2221 gagttgtgga ggaactttta cctaaagaaa gtttagaaat ggatgtagta gaggaagatg
     2281 aagaagaatc gaatgaccca tttgaaactc tgataggtaa taaagggagt cttagaaatg
     2341 ctgtagagca ggctaaatct gctatattgt atccaccaaa agggttacca acgttgatta
     2401 ttggggaaag tggagttggt aagagtttat tttctagaca tatgtatgag tttgcaaagc
     2461 aaaaaaagat agtaaaagag agctccaatt ttgttgtatt taactgtgct gattatagtg
     2521 acaatccaca attattatta tctttgttat ttggatataa aaaaggtgca tttacaggtg
     2581 ctgaatatga tacaccaggt cttgtagaag aagctgatga aggagtttta tttttggatg
     2641 aaatacatag attgcctcca aaaggtcaag aaatactatt ttctatctta gataggggaa
     2701 agtttaggag attaggtgaa actaatgctg aaagaaaagt aagtattatg ttgattgggg
     2761 caactactga aaatgtagag actaatttat tattaacatt cagaagaagg ataccaatgc
     2821 taataacttt gccaccatta catgatagat tactaaaaga gaaaatagac cttatataca
     2881 atatctttca acaagagtgt aatagaataa atgcaaaaat atttgtagat aaaaatgtga
     2941 ttgaaatact tgcactaaaa aagtttagtg gaaatatagg acaattacaa aatatgattc
     3001 aggttctttg tgcaagagct tttatgaagt ttataaattc caaagatgaa gatagtgaat
     3061 ctatagtagt agtagatata aatgaagttt taaagcttaa agattcgttt aaagatgctg
     3121 cctttcaaga gattgaatat acagagataa gaaaatattt gaaaaatgct atatttatac
     3181 catttaattt agaagaatca tcagtaaaag gaagtctttt aagtgatgaa tatatattac
     3241 cagaggacat atacaaaaca attgaaaaga aatattatga cctaaaatcc ctagacattg
     3301 aagatataga tatagagaat attttatgga cttttatttt aaatagattt gctgacttaa
     3361 agtttaatct tgatagtaat gaagaaattt tttcaatgag tgatttaaat agttttgtaa
     3421 gtgatagttt agttaaactg gtaaaagaac ttatgaatga tatagttgaa aaaaatatga
     3481 atttagaagt aaataaaaat atgttcaaat atctagcaat acacttagaa gaagctataa
     3541 aaagaattaa gctaaatcaa aagataataa atgtaaattt agaaaaaata aagattgact
     3601 tttcaaaaga atatgaaatt agtaaaagtt ttgcaataaa aattgaggaa tcaattggta
     3661 ttaagatttc agatgatgaa attggattta taacgctcta cataaagtct gctctaaaaa
     3721 atgaagtgaa aaaagataaa gtagggttaa taataatttc tcatggacgt atagctacag
     3781 agactgtaaa tgtagttaaa gaacttttag gtgtaaagtt tcctgtggct atagatatgc
     3841 ctttagatga aaaaccaata aatatataca ataaggcagt agaattgtca aaaataatag
     3901 accaagggaa aggcatattg tttttggtgg atattggttc acttacaaac ataggtcaaa
     3961 tagtaaataa gagaaccaat ataagtacta aaactattga tagagtagac ctcctaatgg
     4021 cactagaagc aactagaaaa gtttctatgg gagaggaaga acttgatgaa atattttttt
     4081 ctttgctaaa agataggatg ggatataact atgaattaga aaaacacata gataaatcaa
     4141 atgcaattat aacattatgt cttactggag aaggaactgc taagtatata agtaaaacgt
     4201 tggaagaaaa gtatgataac actaaatgtt atcaaatgag tgcattggat gaaagtttat
     4261 tttgtaaaat tgaaaatcta aaagagacaa acaatatatt agctattgtt gggacaataa
     4321 accctaagat accaggtata aattttatac cctataataa agaacttttc aaaaatttgg
     4381 atatctatct atcaaaatca aaacaacaag atgacagacc aattaaatcg tatgaaagaa
     4441 tgcttgatga ggatttagtg atttttgaac cagatatata ttttaaaaag gatttattag
     4501 aatatgtatg ttcaattctt ataaataaag aatatgtaga aaaagattac ttagattctg
     4561 ttttacatag agaagaaatg cttccaacat attctaaagg agctataggt gtgcctcatg
     4621 gagattcttc tactgtaaat agtacaaggt ttgtttttgt taaactaaag aatcctattg
     4681 attggggtgt aggtaatgta aatttcatat ttatgccagt ttttcaggct aatgataaag
     4741 agattgttaa aaatgttctt gagatactaa aagatgcaga atttatgaac aatgccaata
     4801 agtgttttga taaagatgct tttagaagga ttatatttga taaatttaaa catctgtagc
     4861 catagcaaaa aaattgagag gagttagagt aatgaatgta gatttaatat cattgggttt
     4921 agaatctaat gattatgaaa gtgttattga agaattagga agtataatgt gtaaaaaaga
     4981 atatgtaaaa gaaacataca taaatgctgt cttggaaaga gaaaggacat taccaacagg
     5041 tctagatatt ggagacatgt gtgttgctat tccacataca gattcaaagc atgtaaatga
     5101 gtctaatgta gctgtaggga tattgaaaaa tcctgtaaag tttaattcaa tgatagaccc
     5161 aaaagataga cttgatgtag aacttgtatt tttattagca gtaaagaacc cagactcaca
     5221 agtaaaactg ttaaaagatt taatgtcagt ttttcaaaat ataaagttat taaaaaatat
     5281 aaaaaacgca tcaacaaaag aagaagtagc taaattattg gattttatag aaatttaatg
     5341 taggagaatt ttataaataa aaaattaaaa tttaaacaat caaagtaagt attatttttt
     5401 taataggttt aatcttatat aaaataaaaa tttagagtga aaaattagga ggaaattatt
     5461 atgaaacaat ttaatgtatt atcagtttgt ggttcaggga cagttacatc atctatggta
     5521 gcaggtaaat taaaagaagt actaggtaat aaggggattt ctattactac aacagaagct
     5581 agaccaacag aagcactaaa tttagcacaa tcaggaagat ttgactttat aacatttacg
     5641 agtccacttc aaacaggcga ttatggaata ccaactataa atgcatttgc ttgcctaact
     5701 ggtatagggg aagaggcatt ctttgaagaa gttttgactg ttattgaagg gatagataag
     5761 taagttttgg agacgtgaat ttatagtatt taaatcaatg atttagatac tataataagc
     5821 taatattaac taaatatttg tggaaaaaac attttatatg ttgtcataaa ttaaaaaatt
     5881 ataaaaatag tcacttaagt attaaattaa gcttataaat atttataagt aggagggaaa
     5941 aagatgttag aatttatgaa atctataatc gatacatttg gttctgcaat tatagttcca
     6001 attataatat tcataatcgc aaagatattt aaagtaacta ctaagaaatc gtttctttct
     6061 gctgtgtatg caggagttgc tttacaaggt tttacactga ttttaaattc atttacacca
     6121 gtaataacac cagttatcaa taggatggtt gagagtacag gagtaaacct accagttttt
     6181 gatgttggtt ggcaagcaac atcattggtt gcattttcaa caagtgcagg tatgatatat
     6241 ttaggtcttg gtatattatt acaaacaatt ttatttttga taaaatggac agatgtgttt
     6301 caaccatcag atttatggaa taactattct tatatggtat ggggagcaat ggttatagga
     6361 gtaacaggaa attttccttt aggtatagca tgtatggttt tattaaacct atatagttta
     6421 ttaatatcag agttagttgc aaagagatgg tctagttact atagatatcc taattgtaca
     6481 ataatagcta tgcataatgt tgaagcttct gtgtttgcag tatttgcaga ccctatatac
     6541 aataaattgg gattaaataa aatgaaatta aatccaaaag aattagagaa gaaattaggg
     6601 tttttaggtg aaccaattac tttaggtctt tttttaggta tgtttatagg tatattaggt
     6661 aatatgacga gaataaatac tatggaagct tggggagaaa taatgaaagt aggtatatct
     6721 acaagtgcag tgatggcaat tttccctaaa gtagcaagta tgtttgctca agcatttgca
     6781 cctataacag aagcagctag aaagattatg caaaaagctg gaaaccgtga gtggtacata
     6841 gcagtaaatg atgctgttgg atatggtgaa cctgcaactt taatatcagg tcttatatta
     6901 attccaataa tgcttgtaat agctatggta cttcctggta ataaggtatt accagttgtg
     6961 gatttattgg caattccata tatggttcaa ggtttagttg ccatacataa tggtaatata
     7021 ccaaaagtat tagtttcagg tataatttgg tttggattag gattatatgt ttgtacatct
     7081 acagcaccat tatttacaga tatggctaca aatataggtg tagctatacc tgcaggagca
     7141 atgttaataa caagttttaa tatactagga aaacctttga tgggattagt tttctttgca
     7201 tttctaagtg caaatccaat ttatataggt ctttcagttg taatttactt tgttctatgg
     7261 gcattgttta gaaagaacaa aacaagtatt cttgattatt tagaaaaaca agcacttaaa
     7321 aatgtagaag aagagcctgt agcagtttaa gtttataaaa atgaaataaa aataattaaa
     7381 ggagtttata attgatttta tataagtatc agataatacc tgagaaatat ttaaatgaaa
     7441 tatagacttc tttttatttg ataatatttg taattataat gcattgtatc tttatagttg
     7501 agttttctgt ataacctgct atttaaaaca tactctttta tatttataca gtaatgtggt
     7561 ttaattttat aaaatgtaat ctctactggt aaaagacttt gtatataagg catttgcctg
     7621 aataaaccat ttatcttttg tatggcatag atattgctat atagaagtat atagtatgaa
     7681 aggagatatt tatatgggag ataaaatgag agcatcagta ttgtataatg taggtgatgt
     7741 cagatatgaa atggtagata taccagaaat aacagatacg caagtgcttg taaatgtaaa
     7801 atatgttggg atatgtggtt cagatttacc taggtctatg gtaagtggtt tgagtggaaa
     7861 tacaaaatat ccattgattt tagggcatga attttctggt gaagttgtta aaattggaga
     7921 aaaagtaaag catattaatg taggagatag agtagctgtt gcaccattag taccttgtgg
     7981 aaaatgtgat tattgtaatg aaggtaattt tggcttgtgt gatgattaca atataattgg
     8041 aacaagagta aatggagcgt ttgcagaata tgtaagagtt ccagaagaac atattttaaa
     8101 actaccagat acattggatt atgaaactgc tgccggaatt gaaccagcaa ctatagctta
     8161 tcatgggatt tcaaagtcta atattagagt aggagatagt gtagttgtgt taggatgtgg
     8221 tccaataggt cagtttgtta tacaatgggc aaaggtgttt ggtgcatcta agattatagc
     8281 agttgatatt tttgatgaaa aattagaact ttctaaactt ctaggagcaa actatatact
     8341 taactcaaaa gaagtaaatg taatcaaaga aataaaaaaa ataacaaatg gtggtgctga
     8401 tgttgtaata gaaactgctg gtagccgatt tacacaagaa caatctctat ttgtagcaaa
     8461 aaagagagga aatatagtgt ttgtaggtat atcacacaca gaattaccac ttagtgcaga
     8521 cgctactgag tgtatattac gtggagaact taccttgaaa ggttcttgga attcatatac
     8581 aagcccttat cctggaagag catggactgc aacattggat tttatgggaa aaggtgacat
     8641 tatttttaaa cccatgattt cacataaaat aggtcttaat gaagtgggtg actttttaag
     8701 taaaatgagc aagagagaaa ttaatttcaa taaaatccta gtagaaatat aaaaatttaa
     8761 taaaaaattc taaaagcaat taaattttat aactatgaca ttaaataaaa taaaaataat
     8821 tttcttaaat aaaatatagg aggaagaaaa gtgttagaaa atttaaaaga agaagtatta
     8881 aaagcaaact tagaattacc taagaaaaag ctaattactt atacttgggg aaatgtaagt
     8941 gggatagata gagaaaaagg attagtggtg ataaaaccaa gtggtgtaga gtatagtaat
     9001 atgactgtag aagatatggt tgtagttgat ttagagggaa atatagttga tggcaaatta
     9061 agaccttctt cagatactcc gactcatcta gttttatata aagagtttga agaattgggg
     9121 ggaatagtac atacacattc aagttgggca acaatttggg ctcaaatagg aaaatctata
     9181 ccatcttgtg gtactactca tgcagattat ttttatggaa gtataccatg taccagaaaa
     9241 atgactagag aagaaattcg caatgaatac gaaaaggaaa ctggaaatgt aatcattgaa
     9301 gaatttatgg gaagaaatcc aattcattgt ccaggaataa ttgtaaatga ccacggacct
     9361 tttacatggg gaaaagatgc aaatgaggct gtacacaatg cagtagtttt agaagaagtc
     9421 gcaaagatgg cttattatac agagttaatg agtcctgata atattatgga taaggttctt
     9481 atgaataagc atttttcaag aaaacatgga aaaaatgcat actatggtca aaaatgatta
     9541 tctggaggtg aattatgcta gactctttaa aaggtaaagt tgtggaaata gcaattaaag
     9601 cagagcatta tggtttatgt aaagaaaaga ctggtaattt tagtattaga gataaggata
     9661 ctggatatat acttataacc ccatcaggtg taggaagaga agaattaaaa gttgaacata
     9721 tttgtgtatt ggatttggat ggaaatgtaa tagaagttga gaaaggtatt aagccaagta
     9781 gtgaggtatt gatgcatatt gaaatataca aaacaagaga aaatataaat gccatatcac
     9841 atactcattc tttatatgca acagcatttt cagtagcaaa gaaaccaatt ataccaattg
     9901 tatatgaatc agttaattat ggcggttatg tagatattgc tccatacgaa agaccaggaa
     9961 ctttaaaatt agctaagagt gtttcaaaat tactgataga tacagatgca tgcttattag
    10021 aaagacatgg gttgacaact gtaggtaatg atttagacga agcattatta aaatcaagat
    10081 atgtggaaga ggtagcagaa atatactata ggtctttagt attaaatcaa tttaaagaac
    10141 ttgaagtagt agatgttgat gagtttaaat cttggaaata cccagaagaa ataaagtttt
    10201 aatctaaata attttcattg aagtggttaa ttaaaatata tgtattattt atatcaatta
    10261 ctatgtttta ttatgttaat taccgtattt tgcaaatata tttattacat tttttcaaaa
    10321 aaatatagaa tccgaaagcc atataaaatt gacttgggat tctatacttt ttatttatgc
    10381 atttttcttt atctgatttt ctggagaatt tatatgttca aaatattttt tagtttcaga
    10441 tactattata ggtgataatg caagtaaagc tataaggtta ggtattgcca taagcccatt
    10501 tacaatatca gcaattatcc aaacaacttc taactttaag aaagcaccta ataacaccat
    10561 agccacaaat acagttctat acccattcat gccttttaca ccaaacagaa attcaaaaca
    10621 tctttctcca taataactcc atcccaaaat tgtagtaaat gcaaataatg ttaaactaac
    10681 tgtaagtaat attggtccaa atgtaggaat tgctccgtta aaagctgctt gtgtcataac
    10741 agctccattt aggtctgaac accacactcc tgaaataaca agagagaatc cagtaagagt
    10801 acagattata atagtatcta taaaagtacc tgtcatagat ataagacctt gttccgctgg
    10861 ccattcagtt ttagcagcag cagcagctat tggagcacta cctagaccag actcatttga
    10921 aaatacacca cgagcgatac catttctaat tgctagtgac atagttgctc ctaaaaaacc
    10981 accagtagca gcagtaggtg taaatgcact tttaattatt aacataaaag tttcagggat
    11041 tttattccaa aaagatatta aaatgattcc acagattaca acatatataa ctgccataaa
    11101 aggtactatt ttagtagcta cattagatat acttttaagt cctccaaata caactaaagc
    11161 tacaaatact gctaatacaa cccctgtaat tctagggtct atcccgaaac tattatttat
    11221 tgcatctgtt attgaattta cttgagtaaa agtaccgatt cctaaaagtg caactagtat
    11281 accacttata gcgaaaaata ttgcaagagg tctccatttt tctcccatac catttactat
    11341 gtaatacatt ggcccaccag acacttgacc atttttatct ttagttctgt attttattgc
    11401 aagaacacct tctgaatact tagtagccat tccaaagaat gctgctatcc acatccaaaa
    11461 aagtgcacca ggtccaccag ctttgatagc tgtagcaaca ccaacaatat taccagtacc
    11521 aactgtagca gctagagcag tacataaggc tgcaaaactt gaaacatcac cactaccttt
    11581 gttttcagca gagaatatta acttaagagc tcttggcagt ttagttattt gaacaactcc
    11641 aagcttaaca gtaagtagta taccagtacc aactaatagt accagtaggg gtggtcccca
    11701 aataaaagca tcaactttgt ttaaaatatc aattagattc ataaaaacac tccctcattt
    11761 tttttgcttt acataatcaa tagaattttt aatgaagtaa ttgacaggaa ataagtataa
    11821 tttattaata atttctagtg taataaaaaa agctaaatct aaaaaagatt cagctctgga
    11881 tgtacactaa ttagcaacca aaataaaagt attagtaaat actgtttttg gtagataatc
    11941 cctgtccttt tgcctgagag attgagcata aaagccttgc cccttcggcg cccataatgg
    12001 gtctctccag agttccgtaa attttacagt cctactttta aaagtacctg agagtgttac
    12061 tccttcggtg tgctatatag caactcttct ataaaatctt aaccggatat tgatttgtca
    12121 tagcttattg tattaataat attaatataa gtttttatgt tttgtcaact aaaaaattaa
    12181 aaaacaaaga aaaaatataa aaatgtaagc ctatttacga attataaact tagaaagatg
    12241 agtaatatac gtgaaaatga attttgtaat acacatacaa atgaagtgta aaataagttt
    12301 taaataaaaa aataataaaa tcttaaataa ttaattagat atgattaaat tatggtaata
    12361 ttatagttac gatattaaga aaagttctat ttagttagat tttaagcgta atatgagatt
    12421 atgtatagag aaaggatgta tttttagatg ggaaaaatat tagtgctagc agaaaaacct
    12481 tctgttggaa gagatatagc aaaagtttta ggatcaaaaa atgaaaaaaa tggttatata
    12541 gaggggccaa agtatgtgat aacttgggca ctaggtcatt tggttacact tgctgacccc
    12601 gaaagttatg gagaaagata taaatcatgg agcttagaag acctgccaat acttcccaag
    12661 caccttaaga ctgttgtaat aaaaaagagt ggaaagcagt ttaatacagt taaatcgcaa
    12721 atgaatagaa atgatataga tgaaatagtt atagcaacag atgcaggtcg tgaaggagaa
    12781 cttgtagcaa ggtggataat agaaaaatca caggtaaaaa aacctataaa acgtctttgg
    12841 atttcttcaa gtacagacaa agcaataaaa gacggatttg caaaattaaa aagtggaaaa
    12901 gaatatgaaa atttgtatta ctcagcaata gcacgagcag aagctgattg gattattgga
    12961 ataaatgcaa ccagagcttt gacaacaaag tacaatgcac agctttcttg tggaagagta
    13021 caaactccta ctcttgcaat gttgcttaaa agagaagaag aaataagaaa tttcaaacct
    13081 aaagagtatt atggattaga attaattgct acaaagggaa attcagatat aaaatttatt
    13141 tggaatgata aaaacaataa ttcttcaact tttagtaaag aaaagataga atccacatta
    13201 aaaaaagtaa aaggtgtaga cataaaaata tctgaagtaa acaagtcata taagaaaaaa
    13261 tattcacctg cactctatga tttaacagaa ttacaaagag atgcaaataa aatgtttgga
    13321 ttttcagcaa aagaaacttt atctataatg caaaaactgt atgaacatca taaagtactt
    13381 acttatccta gaactgattc tagatattta acatcagata ttgttggaac attaaaagat
    13441 agaataaaag ctgtaaatat tagtgattat tcaaagattt gtaatagatt attaaaaagc
    13501 aatattatag ctaataaatc gtttgttgac aattcaaagg taacagacca ccatgcaata
    13561 ataccaacag aacagaaggt attcatgagt gattttagtg ataaagagcg aaaaatatat
    13621 aatcttgtag taaaaagatt tttagcagta ctatctcctc cttttgaata tgagcagaca
    13681 actataagtg caactgtaga aggagaaata tttaaggcta agggaaacaa agtaataaat
    13741 ttaggttgga aagaaagtta taaagatatt gaagatgaag atgagtatga aagtatacca
    13801 aatgttttag aaaaagatgt acttaaggtc aagggattaa agataacttc aggaaaaaca
    13861 aatccaccac catacttaaa tgagggaaca ttattgactg ctatggaaaa gaatggtcta
    13921 gggacagttg ctacaagagc agatataata gaaaaattat tcaattcatt tttaatggaa
    13981 aagaaaaata aagatatata tataacatca aaaggaagac aattattaga tttagttcca
    14041 gtagacttaa agacaccaga acttacagct tcatgggaaa agaaattatt ggatatttca
    14101 aagggaaaac ttagtaaaaa tacattcata aatgacatga aagattattc aaaagatatt
    14161 gtactagaag taaaaaatag tgataataaa tttaaacatg ataacttaac taaaaataga
    14221 tgtccagaat gtggaaaatt tatgttagag gtaaatggta aaaaaggtaa gatgttgatt
    14281 tgtgaagata gagaatgtaa tactagaaaa actatatcac aagtaaccaa ttcaagatgt
    14341 cctaactgtc ataaaaaatt agaacttcgt ggagaaggtg aggggagaat cttcacttgt
    14401 agttgcggat acagagaaaa gttgtcttct ttcaacaaga gaaagcaaga agaaaaacag
    14461 aaggcatcaa aaaaagatgt taatcaatat ttaaaaaatc aaaataaaaa tcaagagaca
    14521 tttaataatc catttgcaga agcattagct aagctaaaaa acaaataatt ttaaagttat
    14581 tattatacac aattataact ttaactgtat attagttata tgtactgata taatatagtg
    14641 tatagtttag gcatgaaagt agggctgtta aatggattta agtggcatat ttaaatacta
    14701 ttgtaaagag tgtgaaaata catggaataa ttcgagtgtt gaattatttg agaatataga
    14761 aacgtatagt aaagattcac aaaaaaagag ggaaaaagaa ttagataaat tgctaaatac
    14821 aatatcagtt catttagaga ggtatccaag tgatgctgta ttgagaaaaa tgtgggtaaa
    14881 aaagggcgag gttttcttac aaaagacatt ggaaaaagaa aatattttta agttagaaaa
    14941 aatggatgta gaggatagaa aaaaattttt agatataaca aaacagttta ttagagatgc
    15001 tagaaaattt gatgatgatt tacctatagg tgatattatg caagctatga ggaatgtatg
    15061 gatttcaaat gcattacaat tattatttgg taaagaagta tattattcaa aagctaactt
    15121 tgcatatagt atgttatatc catatactga taattattta gacaatacaa atatagataa
    15181 aaatgataag attttattta ataactggtt agaaaaaagg ctcctgggag aacacattaa
    15241 atctaaggat tatcatgaaa gtaaagtatc tcaaatgata gattatattg aaagtgtata
    15301 ccctagagaa aagtttacag aagtttatga atcgttatta ttaatattta aaagtcaagt
    15361 aaatagttta aaacaacatg gtaaggaaaa tcatttgtgt aaagaagatt tattatccat
    15421 ttctattgaa aaaggaggtt catccgtttt agtagatgga tatttaataa gtggattgat
    15481 gacaaaggaa gaaatagagt tttgtatagg atatggattt ttattacaaa tatctgatga
    15541 tttacaagat ataaaagaag atttaaaata caaccataaa actattatta cagagatgtc
    15601 aaaagagggt actttagata aagttgtaaa taaactaata aattttacta ttgagttaat
    15661 agatagtttt aaaattaata ataaaaataa atctgtaata actatgataa agaatgattg
    15721 cttaatgtta attttatttt ctgtagttta taatgctgaa tttttttctg taggatatat
    15781 aaaagaagta gagaaattta ttccatatac aatagattat tcattagaga ttgaagaaaa
    15841 aataaaagaa aaatttaaaa atatagatgt tttaaataat gaaaatgaat ataaagaaat
    15901 gattgatatt atttgtgcag agtagaaaaa aagggagtgt cttagaatag actttttagt
    15961 ttatgaggca ctctttttgt ataaaatcaa atgtattttc atcattttaa caattaaaaa
    16021 gaacttatcc ctatttgaga aagccctttt taatttaaat aaaaatgtca aggttaaact
    16081 atttaaatgc agtaataatc ccattatcat gtaagttttt tatgattgta gctgcgatag
    16141 ggaatccaaa taatccagct attccaaata gttgagcccc aacaaacata cacattaatg
    16201 ttattaaagg atataggcca atttggtgtc ctactacctt tggttctaat atttgtctaa
    16261 caacggttat aattatgtat agtattaaaa gtcctattgc taaattaata tttccattaa
    16321 tgagtgagat aatcatccaa ggtgtcaaaa tacttcctgt acccaagact ggcaaaatat
    16381 caacaagtgc tatgatgaca gatatagtaa atgcattttc aacctttagg atagtaagtc
    16441 caataagtag ttctatgaat gtcactgata gtagtattgc ataggctttt agtagtttta
    16501 aaagagcatt aatactgcta ttttttatat ttattatcat aaattgactt ttttctggaa
    16561 attgttttaa gataaagttt actatttttt gatagtcaaa agtaaagaaa aaagaagcaa
    16621 ttaaagtaat aataagtttt aacataaatg caggtgtttt acttgcaata ctagcaatag
    16681 cattgagtgc atttgttgaa atagaagcta ctaaagacat catagattga cttatattat
    16741 cccaaccaag tattaatgct aggttaacat taggtgtact agcatctatc tttgaaaata
    16801 aagtatttag cgttggttgt atacttgatt tatatatttc aggaagtcta aaaaatacat
    16861 cacttacact tgcaaatatc ttcacaccaa agctaactaa taaaaatata cacaacccat
    16921 aaaaaattaa aagtattact atagaaataa gtgtacgatt taaatttgta ttatttgtaa
    16981 taagtcttat aataggtctt aagatggatg caatgataaa actgattaca aaaggcatta
    17041 ataatggcaa taagaatttt aatacaatat atacaatact tgttattaaa actacatatg
    17101 taaatttaat tataaaattc ttttgctttt gaatatccat aatataaaac ctccaatgta
    17161 tttgatatta ttctaaatat ggtctttttt acagaaaata tactactgta tattgattat
    17221 aaactataaa gcttatgtaa agtaaataaa ttatgtaaaa tttaggttaa ttttgtataa
    17281 agagatactt ttatatttta caattaataa ccaaatacta aaaaatattt taaataaaga
    17341 acttaaaatt gtgataaaat taatttatag atattaaaaa aagtataata tatggttttt
    17401 aagaggtgct aagatgaaaa attttagaga tttaggtggg aacaaaactg aggatggcag
    17461 aactgtaaag aagggattat tttataggtc tgcaaaatta tcaaatctaa gtgaaaatga
    17521 tataaaaatt ttaagagagt taaatattaa atatatattt gattatagaa gtgatgaaga
    17581 agctcgtaaa catccatcaa caataatatc aaatataaaa aatataagaa taccagcaat
    17641 gagagagcta gaagaatcag gaggaagttt tggttctatt gaagatatga ttgatggatt
    17701 gtttgaaaaa gatggtgcat ttaatatgtt aaataatagt tactataatt tgcctataaa
    17761 taatccgtca tataaaaaat tagtagaact tataagagac tattctaatt taccaatatt
    17821 aaatcattgt acagctggta aggatagaac tggtgtgggg agtgctataa ttcttatgat
    17881 tttaggggta tcgagagaga atataatgaa agattatcta aaaagtaatg attttgcaga
    17941 taaagagata gaaagattta tagaatataa gcctaaattt aaggacattc caaaagaaaa
    18001 tttgaaatat atatttggtg taaatgaaga gtatatgaaa actgcattta gaagaattga
    18061 tgaagaatac attagtgtag aagcatattt atatggagaa tttaatttaa ataaagaaga
    18121 aataagaaaa ttaagaaatc aatatctaga gtaaaaggtg agtttatgag tttaaatata
    18181 acagcaagac agataaatat aataaaaata ttgttaaatt caaaagatac aattagtggt
    18241 attgccttaa gtcaagagat aggatgttct tcaaaaacta tacaaaatga aataaaggat
    18301 attaataaac aacttagaaa tggtaaaatt ttgtcaataa gaggagttgg ttataaacta
    18361 gaaggaagtt ttgatgaggt aaatctaaat agcaatctct atgatgatgt agatagagta
    18421 gaatatataa tcagaaaaat attaacctta agtaatgaag aaaaaaatac tataaaactt
    18481 gaagatttag ccgattctat gtatgtaagt gtttcaacag taaaaaatga tttaaaagaa
    18541 gtaaaaagaa tgttggaaaa gtattcaata tcagttaaat ctaagcataa acaaggtata
    18601 tgtgttttgg aaagtgaaga taagatatta aattgtatag ttgacttaag caataagaga
    18661 gataatcaat tgagtttaaa tgatttttta aatgatgata taaaggaaag aaaactatta
    18721 ataaaaaaat tattattaga catattaaat gaaaatggat tagtattaac tgatatagaa
    18781 tttaagagtg tgttaaataa tatattagtt atgttaagca gacataagta taatgaaaaa
    18841 gaatttatag agaattatat agaaaattat aggagcaaaa gaagctcaat tttagaaaat
    18901 gaacaaaaca aagaaattat aataaattca ataaaaacat tttgtaaaaa tttaaaatta
    18961 gctacatcaa tagatataag taatgataag gtatttgaag agtttttata taagcatatt
    19021 agtagtttat gtaaaaaaat aaagttaggt ataaatcaat cacctataat ggctcaagat
    19081 ataaaaataa aatatccatt tgcttttgaa ctagctaata tagctaaaaa gacaatagaa
    19141 aaagatttga agatagaaat taatgaagat gaagttgcaa acatagctct acatatagga
    19201 ggagcagttg aaagagcatc ttataataat aaagataagg ttttcaaaac tataatagtt
    19261 tgtacttcag gcataggcac atcaatgtta ataaaagcta aattagagaa tatatttaag
    19321 gaaaaattag aaatactaaa gattattcct tcatacttag ttgaatatat aaaagttata
    19381 gatgttgatt ttgtaatatc tactgttcct attgaagtag gagatgtgcc agtaataaat
    19441 atatctccaa ttttaagtga gaaagaaatt agattaattg aaaaatatat agaaacagga
    19501 aatatatacc tagatttaga tataaaaagc ctgtttgata gtgaattgtt ttttactgat
    19561 ttggtgttta aaaggaaaga agaagttata gattttatgg caagtaaact tgtacaaaag
    19621 ggctatatag atgaggatat gaaaaaatct tactttgaga gagaaaaaat agcaacaaca
    19681 gaaataggga atatggtaac tataccacat ggagctattg gaaaaatttt tgataataaa
    19741 atagcaattg gtatattaaa gaagcctatt tcttgggaaa tatcagatgt tcgtttaata
    19801 ataatgttag cccttgataa agataaaata ttagattatg aagtaatatt ttcaaaaata
    19861 tataaaagag tagattctat agcaaaagtt ataagtatat gtgaaaatag tagttttgaa
    19921 aaatttgtaa atttatttaa ttagatgggt agtattgtat atacacctgt aaatttggat
    19981 aatataaaac taaataagat aaaaacgata aatttctctt ttaattaaga gaaatttttt
    20041 gactttcaag gatattaata taaagttaag atataaacat aaagcaaata aataaaaaag
    20101 aggtggcaat atgatttata cagtgacatt aaatccatca atagattata tagttaagct
    20161 agatgagcta aagacaggaa gtacaaatcg tgtaaaagaa gaatacgttt atccaggagg
    20221 aaaaggtata aatgtatctc gcatacttaa ggaacttgga aatgataata catctttagg
    20281 ttttataagt ggttttactg gagaatatat aataagaaca ttggaagaaa aagaattgaa
    20341 gacagatttt ataaagataa aaagtggttt ttcaagaata aatgtaaaaa taaaggcgtt
    20401 aaaggaaact gagattaatg gacaaggtcc aaatatagat gatgaagaca ttgatacttt
    20461 atataaaaaa cttgataagc taaatcaaga tgatatttta atattggcag gaagtatacc
    20521 atctacttta gatgaaaaac tatacgaaaa tataatggct agattagaaa aaaagaatat
    20581 aaaagttgta gtagatgcaa ctaaaaatct tcttcttaat gttttaaaat ataaaccttt
    20641 tctaattaag cctaataacg acgaattaga agaactattt ggtgttaaat taaattcaat
    20701 tgaagacatg gtaaaatatg ctagaaggtt aaaggaaatg ggagctataa atgtcttggt
    20761 atcaatggga aaagatggag cattgttgat tacagaggaa gatgaagtgc ttataagtga
    20821 tgttccaaaa ggaaaagtaa aaaattctgt aggagcaggt gattcaatgg tagcaggatt
    20881 tatatctggg tatttgaata ctgggaaata tgattatgct cttaaattgg gagcagcttc
    20941 aggtagtgca actgcttttt catatgactt agccaaaaga gaatacattg ataaattggt
    21001 aaatgagata tctgtaaagc agttttaaaa tattaaaaaa tatatagaaa ggtaattaat
    21061 atttatgaaa attatagatt tattagatga aaagtcaatt aagttaaatt taaattcaaa
    21121 aaccaaatca gaagcaatag aagaattagt agatttggtc gcaaatagtg gaaatttaaa
    21181 tgataaagaa aactacaaaa aagcaatttt ggctcgtgaa gaaatgagta caacaggaat
    21241 tggagaaggt gtagctatac ctcatgctaa aaattcttca gttactaaag cttgtatagc
    21301 agcagcagtg tcaaaagaag gtatagatta tgaatcgttt gacggaagtt tatcaaatct
    21361 attttttatg atagctgcac cagacggagc taacaatact catcttgaag tattatcaag
    21421 attatctaca atacttatgg atgaagactt tagaaataaa cttataaatt caagctctga
    21481 aaaagaattt aaggaaataa tagataaaaa ggaaagagaa aaattcagtg aagaatatca
    21541 agatgagaaa gttactgaaa aaaatataat agatactaaa gagaatgatg ctaataagta
    21601 tcctaaggtt ttagcagtaa cagcatgtcc aactggaata gcacatacat ttatggcagc
    21661 tgaaagttta aataaaatgg cagaaaacaa aggtgtatca ataaaagtag aaactaatgg
    21721 ttcagcaggt gttaaaaata agcttacaaa agatgaaata gaaaatgcaa catgtataat
    21781 agtggcggca gataaaaatg ttgagatggc tagatttaat ggtaaaaaag tcataaaaac
    21841 taaggtggct gatggtatac acaaagcgga agaacttata gacaaggctg taaatggaga
    21901 tgctccaatt taccatggag gagatggaag tcacaacgaa tcaaatgaag aaagtgaaag
    21961 tggatttaga aaagtataca aacacttaat gaatggtgta tctaatatgt taccatttgt
    22021 tattggtgga gggatactta tagcgatagc ctttttactt gatgattata ctattaaccc
    22081 ttcaaacttt ggttcaaata cacctatagc agcatttttt aaaggaatag gagataaagc
    22141 ttttggattt atgttacctg tacttgctgg atatatagca tactctatat ctgatagacc
    22201 agcgtttgtt gtaggatttg taggaggtgc tctagcaggt gatggtggtt caggtttttt
    22261 aggtgcacta cttgcaggtt ttatagcagg ttatttagta gaagggctta agaaaatatt
    22321 tagtgtacta ccagcttcat tggaaggaat aaaaccagta ttgttatacc ctttacttgg
    22381 aacacttttg atgggaatta taatgacatt tttagtaata cctccagtta cagcaattaa
    22441 taatgcaatg gttggatttt taaatggttt aggtggaact tcaaaaatag ttttaggatt
    22501 agtattaggt ggaatgatgg ctgtggatat gggtggacct gtaaataaag cagcatatgt
    22561 atttggagtt gcatcacttg aatcagggca gtttgaaata atggcagcag taatggctgg
    22621 tggtatggtt ccgccacttg ctatagctct tgcaactaca ttttttaaga atagatttac
    22681 taaagaagaa agagattctg gtaaagttaa ttatgtaatg ggattatcat ttgttactga
    22741 aggagctata ccttttgcag ctggagaccc acttcatgtt ataccagctt gtgttggagg
    22801 ttcagcagtg gcaggagcac ttagtatgtt gttcaacgca gctcttcgtg cacctcatgg
    22861 aggagtattt gttataccag tggttaccca tccatttgca tatatattag ctatagctgt
    22921 aggtgctttg gttggaatga tgcttttagc attacttaaa aaaccattaa atcaagaagt
    22981 atagcaatta aaggatattc aagaacttaa aatatgatgt tttataaaaa ttaatatatt
    23041 gctgaattat tttaaaataa ggattttatg aggctgttat ataacgattt gtaattgtta
    23101 tcttgacagt cttttatttt tatataagta aaataagtgt gttttgcttt atttgtattt
    23161 aaattgtttt taagttagaa tataaagaaa attatatatt attttaat
//
LOCUS       DAEQCW010000058        23186 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.058, whole genome shotgun sequence.
ACCESSION   DAEQCW010000058 DAEQCW010000000
VERSION     DAEQCW010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23186)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23186)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23186
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.058"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            344..1180
                     /locus_tag="KRO40_002231"
     CDS             344..1180
                     /locus_tag="KRO40_002231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2093048.1"
                     /translation="MNIKKIFNNNVVVSSLEDGTEIIVTGAGVGFKKKVGDLIDENLI
                     SKKYFVQDDQRDKYNQILNKTSIEYFKISEEIIEKANEVLNTQVNDSIILALTSHIEF
                     AVQREKQGIKLPNLILNETKQLYREEFEFGLWAIDEIEKRIGIKLPEDEAGYIAIHII
                     NGLENSQKDEGINILEFSKQVIQIIEEVHGFKLDVNSLNYTRLITHLKFFVQRILRKE
                     TYNDSDIEDMYKLVNKNYNKPKVCTEEIAALVLDRFEYKISKEEELYLMIHINKITNS
                     GC"
     gene            1533..3110
                     /locus_tag="KRO40_002232"
     CDS             1533..3110
                     /locus_tag="KRO40_002232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2093049.1"
                     /translation="MKKNKLGLWNFFQMLGKTFMFPIALLSVSGMMLGLGAGFTDPKM
                     IEMVPFLGNEYVNLVLNFMLTIGLFAFNNLGALFAMAIPLGLLKKEKEFGAFSGLVGF
                     IAMHIGTNFYLTRADLLVPAEQMSTNGQAMIMGIQTYNTSVLGGIVAGLIVYAIYDKV
                     SNLKIPESLGFYSGPRLVPIVSLIVMSIVGLLIPIVWPPFFNAFQSLGRWISSAGPLG
                     YFSYAVAERVTIPFGLNHLVTSVFRFTPIGGTAVIDGETYFGTLNMFMAYVENNQIIP
                     LDLAGKMEQGKLMIQYGLAGAALAIYRTAKPENRKALKGLLISGVLTVIIGGISEPIE
                     FLFLFISPALFAFHTFMNGLANMVLPYLGVLMGFTGDLIAFISFGVLRGTATGWPIAV
                     LVAVLYFAIYYFVFKWAIIKFNIKTPGREDKEIKVSEGNGSNFKNLSTYKGQQMISAL
                     GGQSNILSLDNCVTRLRLKLQDVSLINEDAIKEAGGIAVVKLDEHTIQVIIGTQVYSL
                     RKQMDKAMEGHLEACND"
     gene            3103..4287
                     /locus_tag="KRO40_002233"
     CDS             3103..4287
                     /locus_tag="KRO40_002233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBH2093050.1"
                     /translation="MINFDKKVDRLGTYCTQWDYVEDRFGKKDLLPFTISDMDLEFPF
                     EITEVLQERLNHRVLGYSRWKHDDFRNSVTNWYIKRFNCSVDSNWIYYSPSVMYSISK
                     LIEMLSNEGDGILINTPAYNAFYDVIINNNRNIIKSHLVNRNGFYSIDFNDFEKKCKK
                     SKIFILCNPHNPTGRVWSELELVKMIGICKNNDVKIISDDIHMDIVYDNRMTPILNVA
                     KDYLDSVFICTSASKSFNIPALTGSYVIIPNEGIRNKFENITRYRDFVNSPAILAILA
                     TMVCYDDCEYWLDELLKYLKENLKYTIDYIKDNLEPLKLVMPEGCYFAWIDFSELKIS
                     GEKFQKLLMDIGEVAIMSGSVYGEEGEFYLRLNVACSREKLEDGLNRIKKTMDYIEKR
                     IL"
     gene            4305..4904
                     /locus_tag="KRO40_002234"
     CDS             4305..4904
                     /locus_tag="KRO40_002234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBH2093051.1"
                     /translation="MGYLKTMVDVMTTEMNAIRCLIDEAGIEYESIVSEIANCEGKVI
                     FMGVGKSAHIGKKLAATFASTGTPSFFVHATEAVHGDLGMIESKDITILISNSGNSME
                     VVNCIKYIKAIGSKTIAFTSNRNSVLAKECDYALIYPAKDEADHLNLAPTTSSTITLV
                     LGDSIACALSKSSNFGSSDFYKYHPGGSLGEKLKTANNG"
     gene            4928..5398
                     /locus_tag="KRO40_002235"
     CDS             4928..5398
                     /locus_tag="KRO40_002235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2093052.1"
                     /translation="MFKMFKKKSIKSPISGKVIELSKIQDGVFSQKIMGEGVAIDSTG
                     DIVYAPINGKIVVVAETKHAFVIELENGMELLIHVGLDTVNLKGEGFEVLVSMGEQVK
                     EGTPMLKINRPLIESKGISLITPVTITNHSEYNMNTCNVGNSVEGGKDTVIEFK"
     gene            5757..6503
                     /locus_tag="KRO40_002236"
     CDS             5757..6503
                     /locus_tag="KRO40_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2087 domain-containing protein"
                     /protein_id="HBH2093053.1"
                     /translation="MKIENLSIDDIKRGYIFNDDLNCYSCIKCTKTYEVGEIYKIGNR
                     FFEASKAIELHMELEHSDYLEQLLNSDSKYNTLTENQKQLFQLFISDLPDKEIAKQVG
                     VSTSTIRHQKFIFREKAKQAKFYLALYESVFEDKSNKSSTIIPIHEHARMVDERYVVT
                     EEERKHILDTSFESMNPLKLKVFSSKEKKKVVILSKILEQFERGKKYSEKEVNQILES
                     IYDDFATIRRYLIEYGFMSRNKECTKYWLT"
     gene            6564..7238
                     /locus_tag="KRO40_002237"
     CDS             6564..7238
                     /locus_tag="KRO40_002237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBH2093054.1"
                     /translation="MNDELKSILYNKGVDIVRFVDISEFPINQTQGFSKAILFCIGLS
                     KKFITDIYNNLPTDSDEFLEKEEKVEELADWISKYIQNKGYRAYSQSEKNNLEHGYFE
                     KAYINPEMQSGISPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVLTDAPISVE
                     RYPLIDSKCMDCNVCVENCPAKAIHGNEWTLPGKRESIIDVSKCFCVLRCMMSCPWSL
                     RYANQK"
     gene            7607..8953
                     /locus_tag="KRO40_002238"
     CDS             7607..8953
                     /locus_tag="KRO40_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBH2093055.1"
                     /translation="MEIETKTPDWINVLELNSKIDITGKYDVSNMIQNIVSDKSLEGS
                     IIYFPKGNYLFEKGIKISQQITLQGDSYYGRGNQVSNLDKKQSIIGTTNFITRGVSNM
                     SIITLSGTSQCIKNINFYYDSHDIEKIPPKNVSAITEYGETQGLSHFEHLFISGFSGI
                     GIEIPYYSTGNDITVSSCGLGMRLGEKSMLSSSKIYECKNGMEITTGVSLNNVRIEEI
                     KEIGINNKGFGFNLIMNLMVDQCGYCGFMFEKMCYSQITARITRCGQYYKSVDYNAYE
                     NMEDRKEEAYSIFYGDILENCNIVLMNRNIDTLESDSLNEHKIYVIKANETNNVMLTC
                     YAEADNFIQCAKGNLLLENGENTYKFYNGEICSVGGVQISDIDEKDLIKIIENTLYID
                     DKGKYLMVPRLKKNTVIYSVLDSTEEINKLHGGIWEQIDVKVLAGESMYYYKKIKD"
     gene            8980..10380
                     /locus_tag="KRO40_002239"
     CDS             8980..10380
                     /locus_tag="KRO40_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093056.1"
                     /translation="MEESIIIKDISGWINVLDYGICNDETKDVSFKLQEIMDAVPEDS
                     IIYFPKGKYLFESGVKIKKRLTLCGDSYILANVPKNTAGVTQFTFKGKKNPKSENRAI
                     ITAKSVRHCIKNICFYSDSCDRDMTSNHEPPTDGKPRFHHNVIINYRNISAVICEDKQ
                     GEPGHYENLSFSGFSGIALDMPNNSTANDITIFTSGLGISTGENSTIANSKVWGCVDG
                     MIISTGTFINGMRVEEIKKVGIKNIGRGLNFITNITIDQCGYCGVWFDSISNVQISGN
                     ITRCGQYYYDVSYDNYLMLDNRVKEAYSLFYGNLLESSNIVLSNTNKDNWEDFKEDKH
                     KVYLVEALETKNVLLTCNIDATDWIVKSEKGNLTYNNMRQTVIFYDGKLSSINGIGIS
                     DEDYGDKVKIKKGNIYINSKDKDIKMHKPEVGDIMSTIIKDKSILSAHYGGTWEKIGE
                     KIEFGITVHYYKLIEK"
     gene            10590..12026
                     /locus_tag="KRO40_002240"
     CDS             10590..12026
                     /locus_tag="KRO40_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBH2093057.1"
                     /translation="MEGRTGIKDGRWINVVERGIKNDGSYNIGPALQDIIDEIETDFC
                     VLYFPKGKYLFTSGVKINKEIVLQGDSNSSTGTTQFITRGVENMSIITLTGKKQCIKN
                     INFYSDSCEIQVNKEPPTKGNPKYHYEMIINKNEKNVEMNNVSAILYDNSKNMIKGLG
                     HYENIYISGFSGTGIRIPYYSIVNDITVSSCGLGIDTGIDTIISNSRISKCQNGMRIR
                     TGTSINNVRIEKIQKVGLISSQVKDYEGYGSYKINNITIDQCGYCGFLFDSVKGSYFS
                     GIIRRCGQYYYNTDYDTYLSIKDRVEEAYSLFYGNYFTECNIDLVSDNKDNWDDGLEY
                     KHKVYVFKTLQIPKLTLRCNIDAYDYIVKSVHGGGNLMLKNNFNNYIFIDSSNPEVIN
                     GINFNYQKNGNLLRLNNGKLSYKNGKEETAIFRPNYGLIVASTDSECEQIETSYGGKW
                     EKLGSEVIGKETVYYYKHHEPDKTNQIQ"
     gene            12370..13314
                     /locus_tag="KRO40_002241"
     CDS             12370..13314
                     /locus_tag="KRO40_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1848 domain-containing protein"
                     /protein_id="HBH2093058.1"
                     /translation="MIVSVSRRTDIPAFYSKWFFNRLKEGFVYVINPMNPKQVSKIEL
                     NPHTVDCFVFWTKDVTPMLYDLNKLKDYKYYFHYTITSYGKEVETCILDKRKVIDSFK
                     ELSRKIGKERVILRYDPIFLSEKYTVDYHIKAFASLCNQLDGFTEKCIISFIDLYKKT
                     KFNTKALHIKPIEITEIETLSKEISKIAHKHGIILEMCSEEYNLSKFGIGKSKCIDDR
                     LISKIIGCEVEVKKDSTQRDICGCVKSVDIGQYNTCRHYCLYCYANFNYAKVEENCRL
                     YKEDNKLLIDTLRDDAKISIRDMKTIKVDKNKQISIFD"
     gene            13483..14415
                     /locus_tag="KRO40_002242"
     CDS             13483..14415
                     /locus_tag="KRO40_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HBH2093059.1"
                     /translation="MNLLKKYPIPIASLILSIFTLGNLLQSYSESLRNVIGFIGFILY
                     AIYIVKIILLRKGVKEQLENPLISSTFPTITMATMIFATYIKPLSLELSIMIWSIGIV
                     GHLVLIVLFSKKFLVKFSIKTVFPSWYIVYVGIVAASVTAPAFNQLLIGKIAFWIGFV
                     SYIVLIPVILKRVWIIKEMPEPSLPSIAILAAPGSLLLSGYINSFSDKNNVVLYLLFI
                     LSIVFYIIVLGYLPKLLRLPFYPSFAAFTFPMAISAMGMKLMNGYLTKSGHFISWISY
                     ASKLEEIIATVIILYVLVLFIIYLSKSETTSKVK"
     gene            14520..14987
                     /locus_tag="KRO40_002243"
     CDS             14520..14987
                     /locus_tag="KRO40_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C_GCAxxG_C_C family protein"
                     /protein_id="HBH2093060.1"
                     /translation="MKTKEEYLKEVRNISEEYFRKGEFFCSEAVLQTINDALGQPLSP
                     EITKLASGFPIGLGKAQCLCGAISGGEMALGIVYGRVHGEAMNPKMFEHAKGLHDYIK
                     KEYGATCCRAITKKWDGDNFMSPERKEHCIKITGQVTEWVADKLIEDEKLNIK"
     gene            complement(15231..16085)
                     /locus_tag="KRO40_002244"
     CDS             complement(15231..16085)
                     /locus_tag="KRO40_002244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009912760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar uptake protein"
                     /protein_id="HBH2093061.1"
                     /translation="MLTIIIALLPVMGWGLMPIVANLKKSSPHEQLLGTSISAFIFST
                     IITLVIHPEITFFSFCISMISGIFWSLGQLMQFKAIQIASVSKVMPISNGSQLTFTTL
                     LAVILFNEWTSSKMLLIGSLSILCIILGILLTNYQTKKSTDKNMLKCVGVVLLSSLFL
                     SLYVVTNQIFLIEGYRIILPQSVGMLITSSIIVKYFSKEIVYMENVLFNLITGILWSI
                     ANLGMFITTNTLGVTISFSISQSCVIVATLGGIIFFKEKKNKKEWLAIFIGIILIMSG
                     VFMLSIIK"
     gene            16251..18215
                     /locus_tag="KRO40_002245"
     CDS             16251..18215
                     /locus_tag="KRO40_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2093062.1"
                     /translation="MLTDMIQNREIKIIKFLLKEGHTTVKAIADDLDVSEKTVSKSLK
                     EVEAVLKKIGLSLIRKPKIGVYIDGDLKKILPYLDNKGSQIPTTREERVIYIYSVLLK
                     SNDYITIQQLSDELYISRGTIERDLAEVEKLLKNEGISIYKKPSKGIKLNISERDKRQ
                     LTAKFIHKFWSRNWYIKQEQESFYQAFEKIQADVNGIFSEDDLSIIIDILRNFSRERK
                     FEFSDYEFQSLVIHLAIAVERIRKGEYIEESLYTGNIENNQMSNTNYLAKQLEEKFSI
                     LLPKSEIGYINLHLVASDQHRDTNELKNTSTNPCETSTNNISNLREIIKNTLYETAYD
                     KDLIDGLTSHVHSSINRLKYGLSIKNPYVNTIKQNFSLSFEQALDLKKVIEFIYDIRI
                     NDDECAYIALHFEAFRERMKELPQNIRVILVCSTGLGSSRLLSARIKKYFPMIKIEKV
                     LSVQELVSSKIDADLVISTIYLELETIPTIVVSPILNESDIRTLERNIQNVSSYTSKK
                     YKSFRNLIFEENILLNIEASNYEDAIKYITDNLIKKGFAKEGIAKSAIERENLSYTSF
                     QSIATPHANPSYIKKSNISVATLKNPITWGNEKVEVIFFISLENDKNLELDEIYEVFY
                     DFIDNKKNINDILSATSTKEVYDLLVEESI"
     gene            18215..18676
                     /locus_tag="KRO40_002246"
     CDS             18215..18676
                     /locus_tag="KRO40_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093063.1"
                     /translation="MKISDVLKKEQIVFNLDTNTKEETIKKLSSIFVENGIVDNEEEY
                     VKSVLEREEHSTTGIGNGIAIPHGKSNAVKKSSIIFAKTKHKIEWDALDEKPVDSIFL
                     LAISNIDKDSNHLVLLSKLATKLMDDDNVDALKLANSEQEIINIFSEEGEM"
     gene            18679..18999
                     /locus_tag="KRO40_002247"
     CDS             18679..18999
                     /locus_tag="KRO40_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH2093064.1"
                     /translation="MKRKIIAVTACATGVAHTYMAAQALKKASKKMGHLIKVETQGAT
                     GIDNELTTKDAQIAEVVIFAVDTKVRNAERFEGKEILEVPVNAPIKDAEKVINDALKL
                     IDTK"
     gene            19015..20115
                     /locus_tag="KRO40_002248"
     CDS             19015..20115
                     /locus_tag="KRO40_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH2093065.1"
                     /translation="MLKKIVSELKKHVLTGISYMIPLVIAGAMIMAISRVGGSFYNIP
                     DIWDAKYAESASSIVRLLHDLDGFGGTALGLMFPVIAAFIGFSIADKLAIVPGLVGGM
                     IAKDIGAGFLGALAVGLIAGYTCLFIKNHVKLPKSAASIVPIFIVPVFGTLITVVLIN
                     YVIGIPFATLNTGLENWLNGLSGTNQILMAAIIGAMMAVDLGGPVNKAALTTSLALLT
                     SGIYAPNTAAMVGIVIPPLGLGLATILAKQKYNKQLREAGKSSLIMGLIGVSEGAIPF
                     AVESPLKVIPSCVIGTAIASAMAVGLGSVNATPISGFYGWFTVENWPMYVLSIAVGTV
                     IVAGLVIVLRGNPVIEDDEFEDDDFDEAEWES"
     gene            20235..22835
                     /locus_tag="KRO40_002249"
     CDS             20235..22835
                     /locus_tag="KRO40_002249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HBH2093066.1"
                     /translation="MIKAHIVNHTHWDREWYFTSGDALVLSEQLFTDVIDELERNPDV
                     SFVLDGQLSILDDYVQLHKEKIEIIKKLIKEDRLHIGPWFTQTDAFFARGESILRNLM
                     IGIFESKKYGKYMKIGYLPDTFGFNAQMPILLKHVGLDNIFFWRGIHLGKQVQSPYFK
                     WKSLNGESYIYAVNMPHGYGTGMLLEPSLKYVNGRLDPAIDFIKSYTDVDEVLIPSGN
                     DQLNIIGDFKNKIKAINDIGKYSYITSSYQEFLKYIKSIESLESYRGEFREPVLARIH
                     KSIGSSRMDIKLACDKLENKLIKRIEPLLVIAKKSKIEISNQLLINTWKKLLEGQAHD
                     SLAGCVTDTVTDDILHRIREANEICDSIENTIVKKISEGLKLSKNDILVFNTEAKRFN
                     GYKEIQVVSDSKNIYFKDNLDATIIEETYVKPRENVLEETPAGNIFIEEPGYYILKVR
                     INIQLPALGYKVVSFELSDKEMVSLDKSNDTFISNDNYKIIYEDGSLNLQLKDGTYIS
                     NFLTLKDSGNAGDTYDFSPLKNDEDIKLSFDKVYTEKALGYEKMVVKGTTLLPLTLED
                     RKNKYLKGKLNVKVSIVLSKENPLMDVKLCVDNTIYNHRLRVHIKTDIKDNKNIASLP
                     FGYITRKNGVLDNWEDIYSEMPIDLEPLESNITLTNQNRSCTVFTRGIKEYQHIEDEI
                     ALTLLATTDELGKPDLLYRPGRASGDTTKKGHIRIKTDKAQMLKELEFSFAIYMDSKS
                     FDELEIANLTHNYLRECVNYQLQDYNFFLYRIDNKIQKSIVNKTVSRELEIISLPENY
                     LISACYPSYYSKDKFIIRVENPSSNRMILDEQIFKNRNGKIVNAIEDVEEEQVYEIAP
                     FDVISILLDL"
BASE COUNT         9135 a         2371 c         4075 g         7605 t
ORIGIN      
        1 aaaagattag tacaaagcta taatctgaat ttcaataaat atatatataa ttaagttgaa
       61 acacttgaaa atactggaaa aaattgaaaa tagtttttgt aatataaaat gtcgattgat
      121 tttaaataat taaatataca taagaaataa ttaaatatat ttcaatgaaa atatgataaa
      181 atatgacaaa ttaattgatg acaataaaaa atattttgtt attgtagtat tatagggtaa
      241 attgcaaaat atatacgaaa gtaaaatttt aaatattgac attaaattaa atatactata
      301 ctatgtaagt gtgatgagag aattttttta gaggggattt atagtgaata taaaaaagat
      361 atttaataac aatgtagtag taagctccct agaagatggc acagaaataa ttgtcactgg
      421 tgctggagta ggatttaaga aaaaagtagg cgatttgata gatgaaaatt tgatttctaa
      481 gaaatatttt gttcaagacg atcaaaggga caaatacaat caaatactta ataagacctc
      541 tattgaatac tttaaaattt cagaagaaat tatagaaaag gctaatgaag ttttaaatac
      601 tcaagtgaat gattcaataa tattagcctt aactagtcac atagaatttg ctgtccaaag
      661 agaaaaacaa ggtataaaat taccaaactt aatattgaat gagacaaaac aactttatag
      721 ggaagaattt gaatttggat tatgggcaat tgatgaaatt gaaaaaagga taggaataaa
      781 attgcctgaa gatgaagcag gatatattgc tattcacata atcaatggtt tggaaaattc
      841 tcaaaaagat gaaggtatta atatactaga gttttcaaaa caagttattc agataattga
      901 agaagtacat ggatttaaat tggatgtaaa ttcattaaat tatactagac ttataactca
      961 cttaaagttt tttgttcaaa ggattctccg aaaagaaact tacaatgata gtgatattga
     1021 agatatgtat aagttagtga ataaaaatta caataaacct aaagtgtgta ctgaagaaat
     1081 tgcagcattg gtattagaca gatttgaata taagattagt aaagaagaag aattatattt
     1141 aatgattcac ataaataaaa taacaaacag tggttgttag gattgtaact gataaagcag
     1201 gcaaaaccta agtcattgag cttaactatt agattaagtt ttttgattta ggttttttta
     1261 ttagatacaa tcaaaataca gacagtgact tttaggattg taactggtta agcaggcaaa
     1321 acctaaatca ttgaatttaa ctattaggtt aagttttttg atttaggttt ttttattaga
     1381 tacaatcaaa tacagacagt ggttgttagg attgtaactg gttgagcagg caaaacctaa
     1441 atcattaaac ttaattatta aattaagttt tttgatttag gtttttctat aaatttgatt
     1501 atgtttttag ataaaaatag gaggggaaaa ttatgaaaaa aaataagtta ggtttatgga
     1561 acttcttcca aatgttagga aaaacgttta tgttcccaat agcactactt agtgtttctg
     1621 ggatgatgct aggacttggg gcaggtttta cagaccctaa gatgattgaa atggttccat
     1681 ttttagggaa tgaatatgtt aacttagttt taaacttcat gttaacaata ggattatttg
     1741 catttaacaa cttgggagca ttatttgcaa tggcaattcc actaggatta ttaaaaaaag
     1801 aaaaagagtt tggtgctttt tcaggattag taggatttat agcaatgcat ataggtacaa
     1861 atttttattt aacaagagct gatttgttag taccagcaga acagatgtca actaatggtc
     1921 aagctatgat tatgggtata caaacatata atacaagtgt tttaggtggt attgtagcag
     1981 gattaattgt ttatgcaata tatgataaag ttagtaattt aaagatacca gaatcattag
     2041 gattctacag tggaccaaga ttagttccaa ttgttagttt aatagttatg agtatagttg
     2101 gattattaat acctattgtt tggccaccat ttttcaatgc attccaaagt ttaggaagat
     2161 ggatttcttc agcaggacca ttaggatatt tttcatatgc agtggcagaa agagttacaa
     2221 ttccatttgg actaaatcat cttgtaacat ctgtattccg ttttacacca ataggtggaa
     2281 ctgctgttat tgatggagaa acgtactttg gtacattgaa catgtttatg gcatatgtag
     2341 aaaataatca gattatacct cttgatttag ctggtaaaat ggaacaaggt aaattgatga
     2401 ttcaatatgg attagctggt gctgcattgg ctatctaccg tacagcaaaa ccagaaaata
     2461 gaaaggcact taaaggactt ttaatatcag gagtgttgac agttattata ggtggtataa
     2521 gtgaaccaat agagtttcta ttcttattca tatcaccagc attatttgct ttccatacat
     2581 ttatgaatgg tctagcaaac atggtacttc catacttagg cgtgttgatg ggattcacag
     2641 gagatttaat tgcatttata agttttggtg tgttaagagg aacagctaca ggatggccaa
     2701 tagcagtatt agtagcagtt ttatattttg caatatacta ttttgtattt aagtgggcaa
     2761 ttattaagtt taatataaag accccaggac gtgaggataa agaaataaaa gtatctgaag
     2821 gaaatggttc aaatttcaaa aatttgtcta catataaagg acaacaaatg atatctgctt
     2881 taggtggtca atctaatata ttatcactag ataattgtgt aactagatta cgtttaaaat
     2941 tacaagatgt atcattaata aatgaggatg caattaaaga ggctggtggt atagcagttg
     3001 ttaaattgga tgagcataca atacaagtaa ttataggaac ccaagtgtat tctttaagaa
     3061 agcagatgga taaagctatg gaaggtcatt tggaggcatg taatgattaa ttttgataaa
     3121 aaagtagacc gattgggtac atattgtacc cagtgggact atgtagaaga tagatttggt
     3181 aagaaggatt tgcttccttt tacaatttca gatatggatt tagagtttcc atttgaaata
     3241 acagaggtgt tgcaggaaag gttaaatcat agagttttgg gatacagtag atggaaacat
     3301 gatgatttta gaaattcagt tacgaattgg tatattaaaa gatttaattg tagcgttgat
     3361 agtaactgga tatattatag tccaagtgta atgtattcaa ttagcaaact tattgagatg
     3421 ttaagtaatg aaggagatgg aatccttata aatactcctg catacaatgc tttttatgat
     3481 gtgataataa ataacaatcg taatattata aagtcacatc ttgtaaatag gaatggattc
     3541 tattcaattg attttaatga ttttgagaaa aagtgtaaaa aatctaagat atttatttta
     3601 tgtaatcctc acaatccaac tggtagagta tggagtgagt tagaacttgt taagatgata
     3661 ggaatttgta agaataatga tgtcaagata atatcagatg atatacacat ggatattgta
     3721 tatgacaata gaatgacacc tatcttaaat gttgcaaagg actatttaga ttctgtattc
     3781 atttgtacat cagcgtctaa atctttcaat ataccagcat tgactgggtc atatgtgatt
     3841 ataccaaatg aaggtattag aaataaattt gaaaatatca ctagataccg tgattttgta
     3901 aattcgccag caattctagc aatattagcc acaatggtct gttatgatga ctgcgaatat
     3961 tggttagatg aactattaaa ataccttaaa gagaatctta aatatacgat tgattatata
     4021 aaagataatt tagaaccatt gaaattggtc atgccagaag gctgttactt tgcttggata
     4081 gatttttccg aacttaaaat aagtggtgag aaattccaaa aattattgat ggatattgga
     4141 gaagttgcta ttatgtcggg gtctgtatat ggtgaagaag gtgagtttta tttaaggtta
     4201 aatgtggcat gttcaagaga aaaacttgaa gatggtttaa ataggattaa aaaaactatg
     4261 gattatattg aaaaaagaat tttatagtag gaagggagat agttatggga tatttaaaaa
     4321 caatggttga tgttatgact actgaaatga atgccataag atgtttaata gatgaagcag
     4381 gaatagaata tgaaagtata gttagtgaaa ttgcaaattg tgaaggcaaa gtaattttta
     4441 tgggtgtagg aaaatctgca catataggta agaaattggc agctacattt gctagtactg
     4501 gtacacctag cttttttgta catgcaacag aggcagtgca tggagattta ggaatgattg
     4561 aaagtaagga tattacaatt ttaatatcaa atagtggaaa ttctatggaa gtggtaaact
     4621 gtataaaata tattaaagca ataggttcta agacaattgc atttacttca aacagaaatt
     4681 cagtactggc aaaagagtgt gattatgctt taatatatcc tgcaaaggat gaagcagacc
     4741 atttaaatct agcaccaaca acatcatcta caattacttt ggttttagga gattctattg
     4801 catgtgcatt atctaagagt agtaattttg gttcttcaga tttttataag taccatccag
     4861 gaggaagttt aggtgagaag ttaaaaacag ctaacaatgg ataaaagcaa aaaggagagt
     4921 agtttttatg ttcaaaatgt ttaaaaaaaa atcaataaaa tcacccatat caggaaaagt
     4981 aatagagtta tctaaaatac aagatggtgt attttctcaa aaaattatgg gagagggtgt
     5041 agctatagat tctacaggag acattgtata tgctccaatc aatggaaaga tagtagtagt
     5101 agcagagact aaacatgcat ttgtaataga attagaaaat gggatggaac ttcttattca
     5161 tgttggttta gatactgtaa atttaaaagg cgaaggtttt gaggtattgg tgagtatggg
     5221 agaacaagtg aaggaaggaa caccaatgtt gaaaattaac cgtcctttga ttgaatcaaa
     5281 gggtatatca cttattactc cagttacaat aactaatcat tcagagtaca atatgaatac
     5341 atgtaatgta ggcaatagtg ttgaaggtgg gaaagatact gtaattgagt ttaaataaag
     5401 aactaaaata caaggttaat atttataaat acctataaac ttatgtttta taagattgat
     5461 tgtatagatt tgttgtataa aaaagaactc tttaattata aattaaggag ttctttttta
     5521 ttttgtaaat attgtttaga tttatataga aaaacactta gtaataaata gaataaataa
     5581 gtatttatat agctaaaaat ctaaatagtt ttgtttaaat atatttttat attttgtaat
     5641 ttcaaattaa taaataatta gatttgataa acaaaaaata aaaatgttga ttacattaat
     5701 aaactttaat ataatatatt tatgaaaaat gtaaactgtg aaatggaggt agtaacatga
     5761 aaattgaaaa tctttctatt gatgatatta aacgaggcta tatatttaat gatgatttaa
     5821 attgttatag ttgcattaaa tgtacaaaaa catatgaggt aggagaaata tataaaatag
     5881 gtaatagatt ctttgaagct tcaaaagcta ttgaacttca tatggaatta gaacatagtg
     5941 attatttaga gcaattgctt aatagtgatt caaagtacaa cacattgact gaaaatcaaa
     6001 aacaattatt tcaattattt attagtgatt taccagataa ggagatagca aaacaggttg
     6061 gagtatccac atctactata cgccatcaaa aatttatttt cagagaaaaa gcaaaacagg
     6121 ctaagttcta tttagcacta tatgaatctg tatttgaaga taaatctaat aaaagtagta
     6181 ctataatacc aatccatgaa catgctcgaa tggtagatga aagatatgta gtaactgaag
     6241 aagagagaaa acacattttg gatacatcat ttgaaagtat gaatccttta aaattaaaag
     6301 tattttcttc aaaagaaaag aaaaaggtcg taattttatc taagattttg gaacaatttg
     6361 aacgtgggaa gaaatattca gaaaaggaag ttaatcagat tttagaatct atatatgatg
     6421 attttgcaac aattagaaga tatctaattg agtatggttt tatgagtaga aataaagaat
     6481 gtacaaaata ttggttaaca taattaaaat aataaatttt actaatgtgt aatgttattt
     6541 ttatctaggg ggaggagtca aatatgaatg atgaattaaa atctatttta tacaataaag
     6601 gtgtagacat tgttcgcttt gttgatatat ctgaatttcc aataaatcaa acacaaggtt
     6661 tttctaaagc aattttattt tgtatagggt tatcaaaaaa atttattaca gatatataca
     6721 ataacttacc tacagatagt gatgagtttt tggaaaaaga ggagaaagta gaagaattag
     6781 ctgactggat ttcaaaatat attcaaaata aaggatatag agcgtattct caatcggaga
     6841 aaaacaatct agaacatgga tattttgaaa aagcctatat taatccagaa atgcaatcag
     6901 ggattagtcc tttaccacat aagacaatag caaatattag tggcattgga tttatgggaa
     6961 aaaataattt gtttgtaaca gaggaatatg gatgtgcttt tagcatgtgt acagtactta
     7021 cagatgctcc aatttctgtt gaaagatatc ctttgattga ttcaaaatgt atggattgca
     7081 atgtttgtgt agagaactgt cctgcaaaag ctatacatgg aaatgaatgg actttacctg
     7141 gaaaaagaga atctattatt gatgtttcaa agtgtttttg tgtattgagg tgtatgatga
     7201 gttgcccatg gtcattaaga tatgcaaatc aaaaataact ttactagaga aggtattaaa
     7261 ttgaatatta taaaattttt aaaatgtaag attatataag atttttcaaa ataaaaattt
     7321 gtatagaaca ctcagaaatg agtgtttttc tattgggatt aaattatatt gatacaaagc
     7381 ttaactattt taatcattat ataaaatttg tattaaaaaa ttaagaataa cttggtaata
     7441 gtgaaaatat aatgagatta taattgattt ataatataac tataatgata ttgtaaaaat
     7501 gaaaattgtc ctctcaaaat tcccaaagag agtaaaagtc acttcagtta tagtcaaaaa
     7561 aatttttctg tgaaaagaat ttagatttga aaaggaggaa ttaatcatgg aaattgaaac
     7621 taaaactcca gattggatta atgtactaga attaaacagt aaaatagata ttactgggaa
     7681 atatgatgta agtaatatga tacaaaatat tgtctctgat aagtcactag aaggttccat
     7741 tatatatttt ccaaaaggta attacttatt tgagaaaggt attaaaatta gtcaacaaat
     7801 aacacttcaa ggagattctt attatggaag aggtaatcaa gtatcaaatt tagataaaaa
     7861 acaatcaatc ataggaacaa ccaattttat aacccgagga gtttctaata tgagtattat
     7921 tacattgtca ggaacaagtc aatgtatcaa aaatattaat ttttattatg atagtcatga
     7981 tatagagaaa ataccgccta aaaatgtatc tgctattaca gaatatggag aaacacaagg
     8041 actatctcat tttgaacatc tgtttatttc tggattttca gggataggaa ttgaaattcc
     8101 atactattca actggtaatg atattactgt tagttcatgt ggtcttggta tgaggcttgg
     8161 agagaagtca atgctttcta gtagcaagat ttacgaatgt aaaaatggaa tggagattac
     8221 tactggtgtt agcttaaata atgtgagaat agaagaaata aaagaaatag gtattaataa
     8281 taaaggattt ggttttaacc tgattatgaa tcttatggtt gatcaatgtg gatattgtgg
     8341 atttatgttt gaaaaaatgt gctatagcca gataactgcc agaattacta gatgcggtca
     8401 gtattataaa agtgttgatt ataatgctta tgagaatatg gaagatagga aagaagaagc
     8461 ttattccatt ttttatggag atattttaga aaattgcaat attgtattga tgaatagaaa
     8521 tattgatacc ttagaaagtg attcacttaa tgaacataag atatatgtaa tcaaggcaaa
     8581 tgaaacaaac aatgtaatgc taacatgtta tgctgaagca gataacttta tacaatgtgc
     8641 aaagggcaac ttgctgttag aaaatggtga aaatacttat aaattttata atggtgagat
     8701 ttgttctgta ggaggtgttc aaatttctga tatagatgaa aaagatttaa tcaaaataat
     8761 agagaacact ttgtatatag atgataaagg taagtattta atggttccta gattaaaaaa
     8821 gaatactgta atatattcag tactagattc tacagaagaa ataaataaat tacatggtgg
     8881 aatatgggaa cagattgatg taaaagtatt agctggggaa tccatgtact attataaaaa
     8941 gataaaagat taaattatca aactaggagg tagtgattaa tggaagagtc tataataatt
     9001 aaagatataa gtggctggat taatgtactt gattatggaa tttgtaatga tgaaacaaaa
     9061 gatgtaagtt ttaagttgca agagattatg gatgctgtac cagaagattc tattatatat
     9121 tttccaaaag gaaaatactt atttgaaagt ggtgttaaga ttaagaaacg attaacctta
     9181 tgtggagatt cttatatttt agcgaatgtt cctaaaaata ctgctggagt aacacagttt
     9241 acttttaaag gaaagaaaaa tcctaaaagt gaaaatagag caatcataac agcaaaaagt
     9301 gtaagacact gtattaagaa catttgcttt tattcagata gttgtgatag agatatgaca
     9361 tctaatcatg aacctccaac agatggaaaa cctagatttc atcataatgt aattataaat
     9421 tatagaaata tatctgctgt tatatgtgaa gataaacagg gagaaccagg tcattatgaa
     9481 aatctatctt ttagtggttt ttctggaatt gcacttgata tgcctaataa ttctacagca
     9541 aatgatatta caatttttac atccggactt ggaattagta caggggaaaa ttcaacaatt
     9601 gctaacagta aggtttgggg ctgtgttgat ggaatgataa tttctactgg aacttttata
     9661 aatggtatga gggtagaaga aataaaaaaa gttggaatta aaaatattgg tagaggttta
     9721 aattttatta caaatatcac aattgaccaa tgtggatatt gtggagtttg gtttgattct
     9781 atatccaatg ttcagatatc aggaaatatc acaaggtgtg ggcagtacta ttatgatgta
     9841 agctatgata attatttaat gttggataat agagttaaag aagcatattc tttattctat
     9901 ggtaatttat tggaatcaag taatatagtt ttatcaaata ccaataaaga taattgggaa
     9961 gatttcaaag aagataagca taaggtgtat cttgtagaag cacttgaaac caagaatgta
    10021 ctattaacat gcaatataga tgctactgac tggattgtta agtcagaaaa aggaaattta
    10081 acgtacaata atatgcgaca aactgttata ttttacgatg gaaaactaag tagtatcaat
    10141 ggaattggta tatctgatga agattatggg gataaagtca agataaaaaa aggaaatata
    10201 tatataaata gtaaggataa ggatattaag atgcataaac cagaggtagg tgacattatg
    10261 tcaacaatta ttaaagataa aagtattctt tctgctcatt atgggggaac atgggagaaa
    10321 attggtgaaa aaatagagtt tggaataact gtacactatt ataaattgat agagaaataa
    10381 gtaaatacgt agtatttgaa tagatgtatt ttattggaga gctaggacta tagttttaat
    10441 gtaaatggtt tggtaatagc atggattgaa taatataaaa ataatataaa aaattaattt
    10501 gattatgtaa aattctatga agtagtaaaa ctgtgacttt agtcatagga ggttcaaact
    10561 aagtaaaagg gaaaggaata tataatatta tggaaggaag aactgggatt aaagatggaa
    10621 gatggattaa tgtagtagaa agaggtatta aaaatgatgg ttcgtacaac ataggtcctg
    10681 ctttgcagga tattattgat gaaatagaaa cagatttttg tgtcttatat tttccaaaag
    10741 gtaaatacct atttacaagt ggtgttaaaa ttaataaaga aattgtattg caaggtgatt
    10801 ctaattcatc tacaggtact acacaattta taactcgtgg agtagaaaat atgagtatta
    10861 ttacattgac agggaagaaa caatgtatta aaaatataaa tttctattct gatagttgtg
    10921 agatacaggt aaataaagaa ccaccgacaa aaggtaatcc taaatatcat tatgagatga
    10981 ttatcaataa gaatgaaaag aatgttgaga tgaacaatgt atcagcaatc ctgtatgata
    11041 acagtaagaa tatgattaaa ggtctaggcc attatgaaaa tatttatata agtggttttt
    11101 cgggtacagg aattaggata ccatattact caattgtaaa tgatattaca gtttcatctt
    11161 gtgggctggg tattgataca ggaatagata caattatttc taatagtaga atatctaagt
    11221 gtcaaaatgg aatgaggatt aggactggaa ctagcataaa taatgtaaga attgaaaaaa
    11281 tacagaaagt tggtcttata agtagtcaag ttaaggatta tgagggatat ggaagttata
    11341 aaattaataa tattacgatt gaccaatgtg ggtattgtgg ttttttattt gactcagtga
    11401 aaggtagtta tttttctggt attataagaa gatgtgggca gtactattat aatacagatt
    11461 atgacacata tttaagtatt aaagatagag tagaagaagc atattcttta ttttatggaa
    11521 attattttac agaatgtaat attgatttag ttagtgataa caaggataac tgggatgatg
    11581 gcttagaata taaacataaa gtttatgtat ttaaaaccct tcaaatacca aaattaacat
    11641 tgagatgcaa tatagatgcc tatgattata tcgttaaatc ggtacatgga ggaggtaatt
    11701 taatgttaaa aaataacttt aacaattata tatttattga ttcatctaat ccagaagtta
    11761 ttaatggaat taattttaat tatcaaaaga atggaaactt gttaaggtta aataatggta
    11821 aattaagtta taaaaatgga aaggaagaaa cagctatatt cagacctaat tatggtctta
    11881 ttgtagcatc aacagattca gaatgtgaac aaatagagac tagctatgga ggaaaatggg
    11941 agaagcttgg ttctgaagta attggaaaag aaacggtata ttattacaaa catcatgaac
    12001 cagataaaac aaaccaaata caataaaatt tgtattatat aatgatataa agttttaata
    12061 tatagtgttt atctttaatg taatattggt atatttgtat agtattaaat ttgttaaaaa
    12121 gtaaaattgt agggtgcttg aaaatagcac cttttttagt ttcattataa aattagtttt
    12181 gaaagtttag gaataatgta tatttatttt taaagaatta taaccttatt aaggatattt
    12241 taaatgctag aaatgaatca gtaaatcata ctggaattat cttaaatgtt ttgattaaat
    12301 taagtattta gagctataat tatattaaaa atatattaga acataattat attactatgg
    12361 aggttaaata tgatagtaag tgtgagtaga agaactgata tacctgcttt ctatagtaag
    12421 tggtttttta acagacttaa agaaggtttt gtttatgtaa ttaatccaat gaatccaaaa
    12481 caggttagta agatagagtt aaatccacat actgttgatt gttttgtatt ttggacaaag
    12541 gatgtaactc caatgttata tgatttaaat aaattaaaag actataaata ttattttcac
    12601 tatactataa catcatatgg aaaagaagta gagacatgta ttttagataa aagaaaggta
    12661 atagattcat ttaaggaatt gtctagaaaa ataggcaaag aaagagtaat tttaagatac
    12721 gacccgattt tcttaagtga aaagtacaca gtagattatc atatcaaagc atttgcgagt
    12781 ttatgtaatc agcttgatgg atttacagaa aaatgtataa taagttttat cgatttgtat
    12841 aagaaaacaa aatttaatac taaagcatta catataaagc caatagaaat tacagaaata
    12901 gaaacattat caaaagagat ttctaagatt gctcataagc atgggataat acttgaaatg
    12961 tgttctgaag aatataattt aagtaaattt gggattggaa aaagtaagtg tattgatgat
    13021 agattaatat caaaaattat aggatgtgaa gtagaggtaa aaaaagatag tacacaaaga
    13081 gatatttgtg gatgtgttaa aagtgtcgat ataggacaat acaatacttg cagacattat
    13141 tgtctgtatt gttatgctaa ctttaattat gcaaaagtag aagaaaactg taggctttat
    13201 aaggaagata ataaattact catagatact ttaagagatg atgcaaaaat aagcattaga
    13261 gatatgaaga ctattaaagt agataagaat aaacaaatta gtatatttga ttaaaataaa
    13321 tatactaatt accttaatat attaagaata tagatacttt tgataataaa attaaactta
    13381 atagatattt tctatataag aaagatggtc ataatatgtc aatttgacca tctttttgat
    13441 ataattaaaa cacaaataat ttagtaacaa aggaggcaga acttgaattt attaaaaaaa
    13501 tatcctatac ctattgcaag tttgattttg tcaatcttta ctttaggtaa cttattacaa
    13561 tcttatagtg aatcattacg taatgtaatt ggatttatag gatttatttt gtatgcaatt
    13621 tatatagtca aaataatatt acttagaaag ggtgttaaag agcaattaga gaacccttta
    13681 atatcaagta catttccaac tataacaatg gcaacaatga tatttgctac atatataaaa
    13741 ccattatctt tagaattaag tattatgatt tggagcatag gaattgtggg tcatcttgtg
    13801 ttaatagtct tatttagtaa gaagttctta gttaaattct caataaaaac ggtatttcca
    13861 tcttggtata tagtatatgt tgggatagtt gcagctagtg ttacggcacc agcatttaat
    13921 caacttttga ttggcaaaat tgctttttgg ataggatttg tatcttatat agttcttata
    13981 ccagtaattt taaagagagt atggataatc aaggaaatgc ctgaaccatc tttaccaagt
    14041 atagctatat tagctgcacc agggtcacta ttattgtctg gatatattaa ttctttttca
    14101 gataaaaata atgtagtatt atacttgtta ttcatattat caattgtatt ttatattata
    14161 gttttgggat acttaccgaa attattaaga ttgccttttt atccgagttt tgctgcattt
    14221 acattcccta tggcaataag tgcaatgggt atgaaactaa tgaatggtta tttaactaaa
    14281 tcaggtcatt ttataagttg gatttcatat gcttctaagt tagaagagat aattgctaca
    14341 gtgattattt tatatgtttt agttttgttt attatatatc ttagtaaatc tgaaactaca
    14401 tctaaagtta aataagaatt attaaatatg tgtatttaat aggaatattg atataaatat
    14461 atgaagataa gataaaccat agaaacttaa tttagcttaa ttttattgga ggaaaacaaa
    14521 tgaaaacaaa agaagaatat ttaaaagaag ttagaaacat atcagaagaa tactttagaa
    14581 aaggagagtt tttttgctct gaagcagttc tccagacaat aaatgatgct ttaggccaac
    14641 ctttaagtcc agagataact aagttagcat caggatttcc gataggactt ggaaaggcac
    14701 aatgtctttg cggagcaata tctgggggag agatggcttt aggtatagta tatggaagag
    14761 ttcatggtga agctatgaat ccaaagatgt ttgagcatgc taaaggtttg catgattata
    14821 ttaaaaaaga gtatggtgca acatgttgta gagctattac aaagaagtgg gatggtgata
    14881 actttatgtc tcccgaaaga aaagagcact gtattaaaat aacaggtcaa gttacagagt
    14941 gggttgcaga taagcttata gaagatgaaa aacttaatat caaatagtgc aatattagtt
    15001 ggtgaattta taaagttaaa tttacttata gtataagata cttgatattc tcgtattgat
    15061 agaaaaattt atagcatatg tatttaatga aatatactta tatttagagt gtggtttaat
    15121 ttcataaata catatgctat tattttaagt atataagcaa atttatttaa ataaatagaa
    15181 acagttaatt tatatgtaca aaactatata tgattagtgt aaataaatac ctattttata
    15241 atactcaaca taaagacacc agacatgatt agtattatac caataaaaat agcaagccat
    15301 tcttttttgt tcttcttttc tttaaaaaat ataatccctc ctaaagtggc tactatcaca
    15361 caactctgag agatagaaaa acttattgta actcccaatg tattagtcgt tatgaacata
    15421 cctaaatttg ctattgacca caatatacca gtaattaaat tgaataaaac attttccata
    15481 tatacaatct ctttagaaaa atacttgaca ataatagatg aagttatcaa cataccaaca
    15541 gattgaggta atataattct atatccttca attaaaaata tttgattagt tacaacatat
    15601 aatgataaaa atagagatga taataataca actccaacac attttaacat atttttatct
    15661 gtagattttt tagtttgata atttgtgaga agtataccaa gtattataca taatattgat
    15721 aaagaaccaa tcagtaacat tttagaactg gtccattcat taaacaagat tacagctaat
    15781 aatgtcgtaa aagttaattg tgaaccattt gaaattggca ttactttaga tacactagca
    15841 atttgaattg ctttaaactg cattaattgt cccagactcc agaatatgcc agaaatcata
    15901 cttatacaaa atgaaaaaaa tgtaatttca ggatgtataa ccagagttat tatagtggaa
    15961 aatataaacg cacttatgga tgtacctaaa agctgttcat gaggagaact tttctttaga
    16021 tttgcaacta tgggcatcaa tccccatccc attacaggaa gtaaagcaat aattattgtc
    16081 agcattaaac tatttccttt catattaaat ttagacagct tttaatttat catctaaaat
    16141 taaagtgttc aatacataaa aattaccgta tttaatcagg aaatattagt agttttttag
    16201 aaaaacattt tccattaaaa taaagacaaa gggaaggagt aaaattgaaa atgttaactg
    16261 atatgattca aaatcgtgaa attaaaataa taaagttttt attaaaagaa ggtcatacaa
    16321 ctgtaaaagc aatagcagat gatttagatg tttcagaaaa aacagtttca aaatctctta
    16381 aagaagtaga agcagtgctt aaaaagatag gtctttcttt aataagaaaa cctaagatag
    16441 gtgtttatat tgatggagat ttaaaaaaaa tacttcctta cctagataat aaaggaagtc
    16501 aaattcctac aaccagagag gagagagtta tctatatata ttcagtactt ttaaagagta
    16561 atgattatat tactatacaa caactttctg atgaactata tataagtcgt ggaactattg
    16621 aaagggattt agcagaagtt gaaaaactgc taaaaaacga agggatttcc atatataaga
    16681 aacctagtaa gggaataaag ttaaatataa gtgaaagaga taaaagacaa cttactgcta
    16741 agtttataca taaattttgg agtagaaact ggtatattaa gcaagagcaa gaaagctttt
    16801 atcaagcatt tgaaaagata caagcagatg taaatggtat tttttcggaa gatgatttat
    16861 caataattat tgatattctt aggaatttca gcagagaaag aaaatttgag ttctctgatt
    16921 atgaatttca gtcattagtt attcatttgg caatagctgt agagagaatt agaaaaggcg
    16981 aatatataga agaaagtttg tatactggta atatagaaaa taatcaaatg tcaaatacca
    17041 attatttagc aaaacaatta gaagaaaaat tttcaatatt attaccaaaa tctgaaattg
    17101 gatatataaa tttacattta gtagcgtctg accaacatag agatactaat gaactaaaaa
    17161 atacttcaac taatccttgt gagacaagta caaataatat atcaaatctt cgggaaatta
    17221 taaaaaatac attgtatgag acagcttatg acaaggattt aattgatgga ttaacttcac
    17281 atgtacattc atcaataaat agactgaaat atggacttag tattaaaaat ccatatgtaa
    17341 atacaatcaa acaaaacttt tctttatcat ttgagcaagc tttagattta aagaaagtaa
    17401 ttgaatttat atatgatatt aggataaatg atgatgaatg tgcttatata gcattacatt
    17461 ttgaagcttt tagagaaaga atgaaagaac ttccacaaaa tattagagta attctagtat
    17521 gcagtacagg attaggttca tctaggttat tgtctgcaag aataaaaaaa tactttccaa
    17581 tgataaagat tgaaaaagta ctttccgtac aagaattagt atccagtaaa attgatgcag
    17641 atttagtaat aagtactatt tatttagagt tagaaacaat tccaaccata gtagttagtc
    17701 ctattttaaa tgaaagtgat ataagaacct tggaaagaaa tatacaaaat gtttcaagtt
    17761 atacttctaa gaagtataaa tctttcagaa acttaatctt tgaagaaaat atattgttga
    17821 atattgaagc ttcaaactat gaagatgcaa ttaagtatat aacagataac ctaataaaaa
    17881 aaggttttgc aaaagaaggt atagctaaaa gtgcaattga gagagaaaat ttatcttaca
    17941 cttctttcca atcaatagct acacctcatg ctaatcctag ttatattaaa aaatctaata
    18001 tatctgttgc aacgttaaaa aatcctatta catggggaaa tgaaaaggtg gaagttattt
    18061 tctttatttc attagaaaat gacaaaaacc tagagcttga tgaaatatat gaagtttttt
    18121 atgacttcat tgacaataaa aaaaatataa atgacatatt aagtgcaact tccacaaagg
    18181 aagtgtacga tttgctagtg gaggagagta tatagtgaaa atatcagatg tattgaaaaa
    18241 agagcaaatt gtttttaatc ttgatacaaa tacaaaggaa gaaacaataa aaaaattaag
    18301 tagtatattt gttgaaaatg ggattgtgga caatgaagaa gaatatgtta agtctgtttt
    18361 ggaaagagaa gaacattcaa ctacaggtat tggtaatggt attgctattc ctcatggaaa
    18421 aagtaatgct gtcaaaaaat cttctataat atttgcaaag actaagcata agattgaatg
    18481 ggatgcttta gatgaaaaac cagtagatag tattttctta ttggctataa gcaatattga
    18541 taaggatagc aatcatcttg tactattatc taaattagca actaaactta tggatgatga
    18601 caatgtagat gcactaaaat tagccaattc agaacaagaa ataatcaata tatttagtga
    18661 agaaggagag atgtagaaat gaaaagaaaa attatagcag ttacagcatg tgcaacagga
    18721 gttgcacata catatatggc agctcaagcg ttaaagaaag cttcaaaaaa gatgggtcac
    18781 cttataaaag ttgaaacaca aggagctaca ggaatcgata atgagttaac tacaaaggat
    18841 gcacaaattg cagaagtagt aatatttgca gtagatacta aagtcagaaa tgctgaacgt
    18901 tttgagggaa aagaaatact agaagtacca gttaatgcac ctataaagga tgcagagaaa
    18961 gtaataaatg atgcactaaa gttaattgac actaaataaa tggagggaaa tataatgttg
    19021 aaaaagatag tctctgagtt aaaaaagcat gtcttaactg gaatctcata tatgattcca
    19081 ttagtaattg caggtgctat gataatggcg atatctcgtg taggtggttc tttctataat
    19141 ataccagata tatgggatgc taaatatgca gaaagtgcta gtagtattgt tagattatta
    19201 catgatttag atgggtttgg aggtactgca ttaggattaa tgtttcctgt aattgctgca
    19261 tttataggat tttctatagc tgataaatta gctattgtac caggtcttgt tggaggtatg
    19321 attgctaaag atataggtgc aggattttta ggagctttgg cagttggtct tatagcagga
    19381 tatacatgtt tgtttattaa aaatcatgtc aaattaccaa aatcagcagc ttctatagta
    19441 ccaatattta tagtaccagt atttgggaca ttaatcactg ttgtattaat caattatgtg
    19501 ataggtatac cttttgccac attaaatact ggattagaaa attggttaaa tggattatct
    19561 ggtacaaatc agatattaat ggcagctatt ataggggcta tgatggcagt tgacttaggt
    19621 ggaccagtta ataaagcagc tttaacaaca tcacttgcat tattaacaag tggaatttat
    19681 gcgcctaaca ctgctgcaat ggtaggaata gttataccac cactaggatt gggacttgct
    19741 actatactag caaaacaaaa atataataaa cagttacgtg aagctgggaa atcatctctt
    19801 ataatgggtt taattggagt aagtgaagga gcaattcctt ttgcagtaga atctccatta
    19861 aaagtaatac cttcatgtgt aattggaaca gcaattgctt cagctatggc agttggttta
    19921 ggttcagtaa atgcaactcc aattagtgga ttttatggat ggtttacagt agagaattgg
    19981 ccaatgtatg tgttatcaat agcagttgga acagtaattg tagctggatt agttatagta
    20041 ttgcgtggaa atccagtgat tgaggatgat gaatttgaag atgatgattt tgatgaagca
    20101 gagtgggaat cttaaaattt aataactatt taagacgtgt tataagctat attcaatatg
    20161 aatcttatac taaataaagt gttaaatatt cagtttagac ttaaatataa aagataaaga
    20221 acagaggaga ataaatgata aaagcacata ttgttaatca tacacactgg gatagagaat
    20281 ggtattttac ttctggagat gcattagtac ttagtgaaca actatttaca gatgtaattg
    20341 atgaattaga acgtaatcca gatgtaagtt ttgtacttga tggacaactt tctattttgg
    20401 atgattatgt acaattacac aaagaaaaaa tagaaatcat taaaaagtta ataaaagaag
    20461 atagactaca tattggacca tggtttactc aaactgatgc attctttgct agaggagagt
    20521 ctattttaag aaacttaatg attggaattt ttgaaagtaa aaagtatggt aagtatatga
    20581 aaattgggta tttgccagat acatttggat ttaatgcaca gatgcctata ctattaaagc
    20641 atgtaggtct tgataatata ttcttttgga gaggtataca tcttggtaaa caggttcaat
    20701 caccatattt taagtggaaa agcttaaatg gagaaagtta tatatatgca gtaaatatgc
    20761 cacatggata tggaactggt atgcttttag agccttcatt aaagtatgtt aatggacgct
    20821 tagacccagc tattgatttt attaaatcat atactgatgt agatgaggtg ttaatacctt
    20881 ctgggaatga ccagttaaat ataataggtg atttcaaaaa taaaattaaa gcgattaatg
    20941 atatcggaaa gtattcatat ataacgagtt catatcaaga gtttttaaaa tatataaagt
    21001 ccatagaatc actagaaagc tatagaggtg aatttagaga acctgtatta gcaagaatac
    21061 ataaatcaat tggttctagt agaatggata taaaattagc atgtgataaa ctagaaaaca
    21121 agctgattaa aagaatagag ccattattag taattgctaa aaagagtaaa attgaaataa
    21181 gcaatcagtt acttataaat acatggaaaa aacttttgga aggacaagca cacgatagtt
    21241 tagctggatg tgtaactgat actgtaacag atgatattct tcaccgtata agagaagcaa
    21301 atgaaatatg tgacagtatt gaaaatacta ttgtaaaaaa gatttcagaa gggcttaaat
    21361 tatctaaaaa tgatatttta gtatttaata cagaagctaa gcgttttaat ggatataaag
    21421 agatacaagt tgtaagtgat agtaaaaata tttattttaa agataattta gatgctacta
    21481 taattgaaga aacttatgta aaaccgagag aaaatgtatt agaagaaaca cctgctggta
    21541 atatatttat tgaagaacca ggatattata tattaaaagt aagaataaat atacagcttc
    21601 ctgcacttgg ttataaagtt gttagttttg aattaagtga taaagaaatg gtgtcacttg
    21661 ataaatctaa tgacactttt atatctaatg ataattataa gataatatat gaagatggaa
    21721 gcttaaattt acaacttaaa gatggaactt acatatcaaa ctttttaaca ttaaaagata
    21781 gtggtaatgc aggtgatacc tatgactttt ctccactaaa aaatgatgag gatataaaac
    21841 tttcgtttga taaagtgtat acagaaaaag ctttaggata tgaaaaaatg gtggttaaag
    21901 gtactacttt actaccactt acattagaag atagaaaaaa caaatatctt aaagggaaat
    21961 taaatgtaaa agtaagtatt gtcttatcta aagaaaaccc attgatggat gtaaaacttt
    22021 gtgttgataa cacgatatat aatcatagac tacgtgttca tataaaaact gatataaaag
    22081 ataataaaaa catagcatca ttgccatttg gatatataac aagaaaaaat ggagttttag
    22141 acaactggga agatatttac agtgaaatgc ctatagattt agaacctttg gaaagtaata
    22201 ttactctaac aaaccaaaat agaagttgta ctgtatttac tagaggaata aaagagtatc
    22261 aacatattga agatgaaatt gcattgacct tacttgctac tacagatgaa ctaggaaagc
    22321 ctgatttatt atatagacca ggacgtgctt ctggtgatac aactaaaaaa ggtcatataa
    22381 gaattaaaac agataaagct caaatgctta aggaattaga attttcattt gcaatatata
    22441 tggattctaa atcatttgat gaattggaaa ttgcgaattt aacccacaat tatctaaggg
    22501 aatgtgtaaa ttatcaatta caggattaca atttcttttt atatcgtata gataataaga
    22561 ttcaaaaatc aattgtcaat aaaactgtaa gtagagaatt agaaataata tctttaccag
    22621 aaaactatct tatatcagca tgttatcctt cttattacag taaagataaa tttataataa
    22681 gagtggaaaa tccaagtagt aatagaatga tattggatga gcaaatattt aaaaatagaa
    22741 atgggaaaat tgtaaatgca atagaagatg tagaagagga acaggtatat gaaatagcac
    22801 cttttgacgt tatttcaata ttattggatt tataagtgta aaagtaagtt tattgtttaa
    22861 agtctgacag atattaatct gccagacttt ttaatttgta taaatttggg taaatattaa
    22921 tgaatggttt tagtatttaa gtatgaattt agtatttaat atagaattta ttgaagtaga
    22981 ataattagtt taacaggata agcagtttaa ataaagaatt attatattag agtgatttta
    23041 tatataattt aaaataataa aattttaata aaatgagtta aagattgtat attaatagag
    23101 ttgatgtagt tacaaaaaag ttaccaattg ttatgtattt acaaaactga tatattaatt
    23161 acataaaatc taaaatagtt tgtaat
//
LOCUS       DAEQCW010000059        22780 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.059, whole genome shotgun sequence.
ACCESSION   DAEQCW010000059 DAEQCW010000000
VERSION     DAEQCW010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22780)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22780)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22780
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.059"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            287..1564
                     /gene="hflX"
                     /locus_tag="KRO40_002250"
     CDS             287..1564
                     /gene="hflX"
                     /locus_tag="KRO40_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBH2093067.1"
                     /translation="MDMAKKGITVGLNINNKSEDFNELMIELENLCSACDIDVVGSIT
                     QNAKQVNRAFYIGTGKVEEILNLIKKENIEIVIFYNELSTSQLKNLEEKLNCEIIDRT
                     ALILDIFAQRAKTREAKLQVELASLKYMLPRLIGSNENLGRQSGGVGTKNRGSGEKKL
                     ELDRRRIEEKITSLNRELDDLKFQRETQRSMRRKSNLPNVALVGYTNAGKSSIMNKLV
                     DIFKNSEEKKVFEKNMLFATLETSVRNIVLANNKEFLLSDTVGFVSNLPHDLVKAFRS
                     TLEEACEADVLLHVIDISNPSYKSHIKVTEDTLKQIGADGIPMIHVYNKIDLIDVEVL
                     DRILDSIDKEGIFVSVKKDINIDKMIKCICDSIFKDYVRYKFLIPYDKGHVVSYFNEN
                     TSIINTEYREDGAILDVECSNIEYNKYKKYALE"
     gene            1797..2294
                     /locus_tag="KRO40_002251"
     CDS             1797..2294
                     /locus_tag="KRO40_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2093068.1"
                     /translation="MDAESLMKKYMVDDDSRKQAIFASIFVMQNKLQTTCDKLDPELT
                     MKQWLLLAIADSVDETLTLTKLGELMGCSRQNVKKLAIALEKKGFIEIEQNEKDSRAI
                     CLVTKDRVQEYSKKVRGMQEKVLQLLFEDFTEKEAEQLFFGIMKLSIGIENVKNYVEN
                     NDVGE"
     gene            2343..2867
                     /locus_tag="KRO40_002252"
     CDS             2343..2867
                     /locus_tag="KRO40_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBH2093069.1"
                     /translation="MKSVVVIYKSKYGSTKKYAKWLSELLSCDIFETKNINIEKVMKY
                     DTIILGGGLYACNIAGISFLKKNYKELKKKNLVVFGVGAAPYDDEVIKKLREVNFKDE
                     LNKIPCFYCRGAWDETKMSFIDYTLCSFFKKSIAKKERQGLKPAEAPLLSGEAFDWCN
                     KENLTPILDYIREL"
     gene            3179..4543
                     /locus_tag="KRO40_002253"
     CDS             3179..4543
                     /locus_tag="KRO40_002253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="HBH2093070.1"
                     /translation="MDIKELVKMQRKYYNTGKTRDISFRIEQLKKLKLVVSQNEEKIL
                     LALKKDLNKSDFEGFMTEVGMFYSELNFAIKNIRKWSKIKRVKSSMVNFPSISKVVPQ
                     PYGVTLIMSPWNYPFQLALIPLVWSLAAGNCVILKPSEYSVSTSSVVKDIVEDTFSKE
                     YVAVVQGSQEESEKLLLERFDYIFFTGSTNVGKIIMKSASEHLTPITLELGGKSPCII
                     LKDANIDLTAKRLTWGKLINAGQTCVAPDYVLVHEDRKNELIEKIKYYTNKYFGDNPC
                     NNEQFPKIINQRHFNRILSLIDKDKIVYGGNYNKETLKIEPTIVDNVNWDDNIMKEEI
                     FGPIFPILTYKDLDEVIQKIIQMPNPLALYIFTKNKYLENKLLEMISAGGCCINDTVT
                     HIATNYLPFGGIGESGMGSYHGKAGFDTFTHYKSVLKKLNLDVPIRYAPYDNKLIKVL
                     KKIM"
     gene            4682..5848
                     /locus_tag="KRO40_002254"
     CDS             4682..5848
                     /locus_tag="KRO40_002254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH2093071.1"
                     /translation="MKINWNTKYTTIAIYTFIIAASSIIFYLVSSQIDVFSNNLDAIF
                     TTLQPFIIGFAIAYLLNFILKFYEDRIFIKSEKLKKLKQSSKRGLGLLLTYATATLIL
                     YLFMHFVLPQVIESIVGLANDIPMYVNNATKLIDKLMTDLNLDEQYFNLAVDKWNEFV
                     TYIIKFVTDLIPILGSMLKNVASSIWNIVLGLIVSVYLLIDKEKFYGLSKKITYAVFT
                     EKQAARILELTHRSNYTFGRFLGGKILDSFIIGILTFVILTLVKMPYTLLISVIIGIT
                     NIIPFFGPLFGAIPSTLIVMFVSPIKAFWLLLIILIIQQIDGNIIGPKILGDSIGISA
                     FWILFSLLVAGKLLGFIGMVIGVPMFAVIYSIIKDIVESKLDKKGLPTDTSDYM"
     gene            5965..6747
                     /locus_tag="KRO40_002255"
     CDS             5965..6747
                     /locus_tag="KRO40_002255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HBH2093072.1"
                     /translation="MAFIECKFKSKYTGGETDIIVILPVANGKELFSGKEIYDFEGKF
                     KTLYLFHGLEDDQSSWIRYTNVEHYAKNKNIALVIPRVETSFYTDMAYGHQYFTFVSE
                     ELPKFVRAIFPLSDKREDNFVAGMSMGGYGALKLALSKPKEFSAVASFSGSPDMIHEL
                     ENQQIETNADILFHDFGRPEDARNSENDLLYILKNLKERNEDIPKIYQFCGDRDFLYK
                     NNQMFKKYADSLGVDVEYEECVGGHEWRLWNLWIKKFIDIIG"
     gene            complement(6866..7519)
                     /locus_tag="KRO40_002256"
     CDS             complement(6866..7519)
                     /locus_tag="KRO40_002256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093073.1"
                     /translation="MSKSEKGKETKASIISAARELFFEQGYHKTTTRQIAERANINLG
                     LISYYFSSKSEIGAIIYEDIRNEMQSLIYNYHEEGTMMMFFLAMNADLCFLLKNEAYR
                     NFYLDIAYEEAILSYQRSVTEMVMKRYVNDKESIEHDELILSCIGILAMKPEIIRVYT
                     SHKYDISSQAVIKHFTKQFLINLGHSTDLCEEILEELSKYYIDIVDNFTPIITRVRT"
     gene            complement(7543..8907)
                     /locus_tag="KRO40_002257"
     CDS             complement(7543..8907)
                     /locus_tag="KRO40_002257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBH2093074.1"
                     /translation="MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATI
                     AATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALACFINAFFAGKLRSLSCDITPADY
                     IETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
                     YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKS
                     ISDFMYTVLPLVLGSIFSYESFLRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAI
                     GGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADSLMTSMSAIISRDIY
                     NKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFA
                     PFVIGLCWKGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKF
                     SKKD"
     gene            9565..10995
                     /locus_tag="KRO40_002258"
     CDS             9565..10995
                     /locus_tag="KRO40_002258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093075.1"
                     /translation="MSSQESKPKGNLISNFRDDMRDPKKRAIYTYSSSINLAYNFIGY
                     FVSTVTNIFLTDVAKLGVIMAGGMQIIQSFIKIAVAPITGTVFDKQPFKKGKYYPWLR
                     YAPAALALTYGIFFIVPLMKISPALLLPLMTALLLIASCAQQVVFTIIYAIYPVVAKT
                     PRDRVIGSTTTNIFKEVGKFLVGFSYPLLLVLFADVLGGEGMGYLGTYLFFAAGCLLV
                     FWFSSTEIIKSGAEEEVLQKEEKPKIKASEMAKALFTNVPLMMAFCLEFLICIRSIGL
                     GPLAPYYFKYVIEDERGLAVFLSIMPLVSVAFMFFAPVFIKICREQKLASIISFSICA
                     LCHLLVAWTPWGKTTLGVTMLLAIGGGFSNVVSIINLNFFAGSCDYGHWKSGKDLPGL
                     SMSLYPVAIQVGVLLATTIRTVLMNSMGYQADMVVTEAVKSGFINMISYSMAIPLIIA
                     VVIAILYPVSDKKLNQIREELNQRNA"
     gene            11098..12201
                     /locus_tag="KRO40_002259"
     CDS             11098..12201
                     /locus_tag="KRO40_002259"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBH2093076.1"
                     /translation="MIEKLLRNTVKELHQYVPGEPIEKVKEKYGVKEIIKLASNENPL
                     GPSPKAIEAMIEMLKQGQLYPEPEANELRRKLAEKLDLKPENFIVANGADNVITLIGE
                     AFINRGDEVIYCNPTFPSYRTATIKNEGIPVEVPLTEDYKYDLQGILDKITDKTKLIC
                     VCNPNNPTGTIVDDKELEEFLKKVPENIITILDEAYIEFLTVPNYVDGLKYVRENYNV
                     IVTRTFSKIYGLAGLRVGYGIAKDEIIRTLFTVKEPFSANRVAISGATAALDDEEFIK
                     ETYELNRVGMAYFKEEFTKMGFDVVDSQSNFLYVDMKTDIPKLFEDLKKRGFVIRPSA
                     THARVSIGTMEENRKFVAVLKEILNIKGEPSIG"
     gene            12216..12452
                     /locus_tag="KRO40_002260"
     CDS             12216..12452
                     /locus_tag="KRO40_002260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2093077.1"
                     /translation="MKRGVDMNLKINAERCKSCEYCVISCKKGALKISSKINKEGYAH
                     VEVDESKCILCGICYQVCPDNVFEIIKEEACQEA"
     gene            12469..13518
                     /gene="vorB"
                     /locus_tag="KRO40_002261"
     CDS             12469..13518
                     /gene="vorB"
                     /locus_tag="KRO40_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH2093078.1"
                     /translation="MKKMWKGNHAIAEAALRGGCEFYAGYPITPQTEVMEFLSHRMSE
                     LGRTFIQSENEMAAIYMVYGAYASGMRSMTSSSGPGISLKQEGISYLCANHYPCVIVN
                     VQRWGPGLGSLDSAQTDYLRDTRGGGNGDYHLIVYAPNSIQETVDLMYNSFDVAEKYR
                     VPVEILTEAALGQMMEPVEFPEFKKREGDLGWTYDGSNRDHAKVADNQKPTFCMEKRM
                     RITENEQQWEDYQVEDAEYVFVAFGIPSRTTMNAVRRLREQGEKVGIIRPITVWPFPY
                     KAFEKVSKDVKGFISVESTDTGQLVEDVALASKKVCKENVPVYGLFSGNHIPKTLQVM
                     DTYSKIKSGEIKEVF"
     gene            13520..14260
                     /locus_tag="KRO40_002262"
     CDS             13520..14260
                     /locus_tag="KRO40_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH2093079.1"
                     /translation="MATEKLTPSVVSIPNKFCPGCGHGIVNRIIAEVIEEHGYEKNHV
                     LTLGVGCVCNMNFSWNGDKMQTAHGRASSTAIGVKVALPDTLVMTYQGDGDAYVIGLS
                     ETLNTAYRNHNVTVFVINNNNFAMTGGQMSWTTMPGQVTTTSVNGRDIKTTGSPLKVP
                     EMVANFFDVAYVARGSVHSPKEIINLKKYIKNAIEAQLNGEGYSLVEILAPCPTNWGV
                     SLEKSIKWMEEEIVPYYALGEFKQRDGE"
     gene            14263..14802
                     /locus_tag="KRO40_002263"
     CDS             14263..14802
                     /locus_tag="KRO40_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH2093080.1"
                     /translation="MEKELVFAGFGGQGVLTLGLIVAESALELGKQVTWMPAYGPTMR
                     GGKAYSVVKFSDESIGGPDMEEIDVLVAMNKPSLDYINLVKEGGTVVINTSAIDENVT
                     LREDISVVKINCQELAQKVNNPKAANIVVLGALIAKTGLFEKELALKTMCDFFEEKGK
                     GKFNVQNEAAFMEGYNNAI"
     gene            14926..17025
                     /locus_tag="KRO40_002264"
     CDS             14926..17025
                     /locus_tag="KRO40_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate--CoA ligase family protein"
                     /protein_id="HBH2093081.1"
                     /translation="MSLEKLIRPKSIAIVGVTDKLGFGRSAALSIVKSKETDRVYYVN
                     PKREELFGRKCYKTIQEVPEVVDCVVVCTPRNVVPSVLKDSGELGTKAAVVYASGFAE
                     EGTEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGSKWDLYTKKPGIG
                     IVGQSGFITAEIVSSDYFNISYGFSTGNGNIVTLEDAVDFLVDDDYASVIAIYLEGLK
                     NPQKFIDALKRAAQKRKPVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVI
                     SVENLEQFMCLAQAFSVLDGNLPANSNFAAINFSGGENTICADLAEENGVELAEISSE
                     TKEEMKKYLPGFATPKNPLDATTALFHEKDMIVGLLHTFEKDDSVGFTMVGANIRDEE
                     NEMHETLCKAVSEAREQGLKKPVFAVPTLEGNRYLDYRTRLEDNQVPIMSSVGTTFTC
                     FNKMAKFIDYDYSKRTLEFKAVKKRESNNVVALSELDSKIEMKKYGVPVPGQGNAKSI
                     DELDEILKYIKYPVVLKINSSEILHKSDVGGVKIGIKNRDEAVDAYNEILTNVKKAKP
                     DANIDGILVQEMVESGIEIIIGITNDDQFGPLLLVGLGGVFVEVFKDTTLYPLPINHD
                     EAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKDEVKEIDLNPVFVY
                     PKGKGVCAVDALIVKYK"
     gene            complement(17292..17807)
                     /locus_tag="KRO40_002265"
     CDS             complement(17292..17807)
                     /locus_tag="KRO40_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferritin"
                     /protein_id="HBH2093082.1"
                     /translation="MISAKMEKLLNEQINHELYSAYLYLSMSSYLEAEGLKGFSNWFY
                     VQYKEETDHAMFFYKYLHNVGGKVQLDAIPMPDSDFTSAMDILERTLAHEKKVTALIN
                     NLAAVANSESDFRTSQFLLWFISEQAEEETNCEDNIKRVKLAGEGGLFFVDQEFANRT
                     YAAPTNPPVTI"
     gene            complement(17899..19110)
                     /locus_tag="KRO40_002266"
     CDS             complement(17899..19110)
                     /locus_tag="KRO40_002266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBH2093083.1"
                     /translation="MSNKQGSNIKDVKIKNKLIILKLLSTNTPMSRVDLAKSTGLTKM
                     TLSNLVTELINENMIREIESSTLNAHSSGRKPILLDISNISPCICGILIRRNICKVII
                     SDLKGNIVKQLSETYPKCLSNDVLKDIIKRMFTKIMKINKRDIIGIGISSIGPVDDIN
                     GTILNPPDFGNISNLNIVDFIKEMSDLPIFLINDANSGALAEKMYGLGKNISNYIYLH
                     IMNGIGAGLVLENKLHTGNLGQSGEIGHTSINFSGPLCSCGNNGCLDYYTSVSNLIKR
                     IESLSHIYPNSPLINCKDFSLVKLIDEANNKDSLAMFLLDEFCTYVSYALVNTLTLID
                     CSSIIIGYDFNIPGTFIENTLLKKLTASASFSKYKKISVRHSNFGANAPLIGSIAIVS
                     YNFFNGSINFY"
     gene            19786..21228
                     /locus_tag="KRO40_002267"
     CDS             19786..21228
                     /locus_tag="KRO40_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2093084.1"
                     /translation="MRTIRRVLALGLTLAIFLINVPNVDALTSDTIKGNNIYETAGLI
                     ADKKSYDTAIMVNMDNSIADGLSASGLAGAVDAPILLAQKNKIPNETKQRLKNVKKIY
                     IIGKELSISKSVETELKNTGAQVTRLGGDDRIKTSYSVAKEVNGIKKVDEVILTNAYK
                     GEADTISAAPVSVRDIAPIVLTDGKSVPFSTSNVKTYAVGGSISMSTSLVNKTNAKRL
                     GGSDRYDTNKKVIKEFYPDASEFYLSDGYDLVNALTGSTIAKENPIVLVSESSDKSIL
                     AGADKITRLGSISDSVYNKCVSAAQNNGDSSTKGESPMKNETSILGQPTASLEACLKW
                     AKSKKANDLFIELIPILYDTAVQEGVNPVLAVAQSAKETGFCNFGGVLDASFKNPCGL
                     KTSVGGSDTDKNAHSRFDTWEEGILAQIQHLCLYAGQDGYPLSNPVDPRHEKSLFGKA
                     KTVESLSNNWAGGQYGQDLVRMMGEIEATK"
     gene            21270..21623
                     /locus_tag="KRO40_002268"
     CDS             21270..21623
                     /locus_tag="KRO40_002268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093085.1"
                     /translation="MKKSNIFSIIFPTVIMVLMFLTFATDIFNIPDIQSKSIFVVGMV
                     LIFPISFLIQGIICVLNKTNWILSLIVSLVTYIVLMYIFLNDSAYIYVLLYTAFYMIG
                     HITAKLYYKIKTFKN"
     gene            21814..22635
                     /locus_tag="KRO40_002269"
     CDS             21814..22635
                     /locus_tag="KRO40_002269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBH2093086.1"
                     /translation="MNLIDNHIHTNFSSDGKDSMEDTIKKAISIGVRYLTFTDHLEHD
                     EDRGFCINYNDYVPVFNKFKEKYKKDIELLLGVEVGYRKHLKNEIEEIINSNPFDFVL
                     CSTHTIDNVPVPSKEYFKGLSKEDAYYKYFNSILETNREFGDYNIYGHLDYISRYGIY
                     SDNRVIYNDFKDVIDEVLKSIINNGSGIELNTSGYRYGLNAIHPNEDILKRYKELGGF
                     IVTVGSDSHRVEDICKDFDVAYDMLKYLDFKYVSLFKERETYFVNIEKVKSNNIA"
BASE COUNT         8765 a         2607 c         3900 g         7508 t
ORIGIN      
        1 tatttagaat tttaatcctt cttatgatat aagtagcttg ttttgtatta cttagatttg
       61 taaggagttt ttttattgaa aaaactgcat aatatatttg ggaggaggtg taagaaagtg
      121 attttttata taagattgag aaaataatgc acgattatgg ttattataat agtaaataag
      181 aagtgtcatt taaggataag ataaaaagca aaattcttga tgaatttaat tatagagcca
      241 taatctcgtg ctatagatta aataaaaaat agcagataag gagaatatgg atatggcgaa
      301 aaaaggaata acagtaggat taaacataaa taataaatct gaggacttta atgaactaat
      361 gattgaactt gaaaacttat gttcagcatg tgatattgat gttgtaggga gtataactca
      421 aaatgcaaag caggttaata gagcatttta cattgggaca ggtaaagttg aggaaatatt
      481 aaacttaata aagaaagaaa atatagagat agttatattt tacaatgaac tttctacatc
      541 acaactaaaa aatcttgaag aaaagcttaa ttgtgaaatt atagatagaa cggcattgat
      601 acttgatata tttgcacaaa gggcaaaaac tagagaagct aaacttcaag tagaattagc
      661 aagtttaaaa tatatgttac caagacttat aggttcaaat gaaaatttag gacgtcaaag
      721 tggtggagtt ggtactaaaa atagaggttc tggtgagaaa aaattagaac ttgaccgtag
      781 aagaatagaa gaaaagataa catctttaaa tagggagttg gatgatttaa aattccaaag
      841 agaaactcaa agaagtatga gaagaaaatc aaatcttcca aatgtagctc tagttgggta
      901 tacaaatgct ggtaaatctt caataatgaa taaactagta gatatattta aaaactctga
      961 agaaaagaaa gtgtttgaga aaaacatgtt atttgctaca cttgaaactt ctgtcagaaa
     1021 tatagttctt gcaaataaca aagaattttt attatctgat actgttggtt ttgtaagtaa
     1081 tctaccacat gatttagtaa aagcatttag gtcaacatta gaagaagcat gtgaggcaga
     1141 cgtactgtta catgttattg atatttcaaa tccaagctat aaaagtcata ttaaagtgac
     1201 agaagatact ttaaaacaaa taggtgcaga tggtatacct atgatacatg tgtataataa
     1261 aattgattta atagatgtag aagtattgga tagaatttta gatagtatcg ataaagaagg
     1321 tatatttgtt tcagttaaaa aagatataaa tatagataaa atgataaaat gtatttgtga
     1381 tagcatattt aaagattatg taagatataa gttcttaatt ccatatgata aaggtcatgt
     1441 agtttcttat tttaacgaaa atacgagcat tataaataca gaatacagag aagatggagc
     1501 tattttagat gtagaatgta gcaatataga atataataag tataaaaagt atgctttaga
     1561 gtaaattttg aaaaacttat tatagcctaa aatatattta atttataatt tattataaat
     1621 tgattgtaaa tatgatttta tgaaacggta tagccataat gctatgccgt tttgccattt
     1681 ataataaaaa taaatttatt gacataatag taactaatta ctataatata aagtaattag
     1741 ttactattta aaattatcaa aaaattaaaa tctaagataa agagaagtgt ataataatgg
     1801 atgcagaaag tttaatgaaa aaatatatgg tagatgatga tagtagaaaa caagctatat
     1861 ttgcaagtat atttgtaatg caaaataaac ttcaaactac atgtgataaa ttagacccag
     1921 aattaacaat gaaacaatgg ttacttttag ctattgcgga ctctgtagat gaaactctta
     1981 cattaaccaa acttggagaa ttaatggggt gttcaagaca aaatgtaaaa aaactagcta
     2041 ttgctttaga aaagaaaggt tttatagaaa ttgagcaaaa tgaaaaagat tcaagagcta
     2101 tctgtcttgt gacaaaagat agagtgcaag agtattctaa aaaagtgaga ggtatgcagg
     2161 aaaaagtatt acagctttta tttgaagatt ttacagagaa agaagcggaa cagttatttt
     2221 ttggaattat gaaattaagt ataggaattg aaaatgtgaa aaattatgta gaaaataatg
     2281 acgttggaga ataagcaagt atcaaatcaa ctttgtatga catcagagag gggagaattt
     2341 atatgaaaag tgtagtagtg atttataaga gtaagtatgg ttcaacaaaa aaatatgcta
     2401 aatggctttc agaattattg tcttgtgata tttttgaaac taagaatatt aatatagaaa
     2461 aggttatgaa gtatgatacg attattttag gaggaggtct ttatgcttgt aatatagcgg
     2521 gaatttcttt cttaaaaaaa aattataaag aattgaagaa aaaaaattta gtagtatttg
     2581 gcgtaggagc tgctccatat gatgatgaag taataaagaa attaagagaa gtaaacttta
     2641 aggatgaatt aaacaaaatt ccttgctttt attgtcgtgg ggcatgggat gagacaaaaa
     2701 tgtcttttat agattatact ctttgtagtt tttttaaaaa atctatagct aaaaaagaac
     2761 gtcaaggtct taaaccagca gaagcacctt tattgtctgg agaagccttt gattggtgta
     2821 ataaagaaaa tttaactcca atacttgatt atataagaga actttaagag gtatatattt
     2881 gtaattattt attatctaaa gttagatttc atagaaattt actagacatt atttataaaa
     2941 taatattatt aaagatggat aatttaattg tttcaataag gttataattt taaaaaatgt
     3001 ttattttaaa ataaattatt ttataagctt acttatactt aataaggggc tttttttatt
     3061 ggaagattta tgttatattg agatgaattt attatgatat aaaaaataat gttaggataa
     3121 atttaaatct ttttctaaaa atgtattaat ataattctta aagaaaggat ttttaataat
     3181 ggatataaaa gagttagtta aaatgcaaag aaaatattat aatacaggta aaacaagaga
     3241 tatatcgttt cgtatagaac agttgaagaa acttaagtta gttgtatcac aaaatgaaga
     3301 aaaaatactt ttagcactaa agaaagattt aaataaatcg gattttgaag gttttatgac
     3361 agaagtaggc atgttttata gtgaattaaa ctttgctata aagaatataa gaaaatggag
     3421 caaaataaaa agagttaaat caagtatggt taattttcca tctatatcca aagttgttcc
     3481 acaaccttat ggtgttactc tcataatgtc accttggaat tatccatttc aattagcact
     3541 tataccatta gtttggtcat tagcagcagg gaattgtgtt atattaaaac cttctgaata
     3601 ttctgtgtca acatctagtg tagttaaaga catagtggaa gatacttttt caaaagaata
     3661 tgttgcagtt gttcaaggaa gtcaagaaga aagtgaaaag ttactattgg aaagatttga
     3721 ttatatattt tttacaggaa gtactaatgt tggtaaaata atcatgaaat cagcatcaga
     3781 gcatttaact cctattactt tagaacttgg aggaaaaagt ccttgtatca ttttaaaaga
     3841 tgctaatata gaccttactg ccaaaagact tacttgggga aaactaataa atgcaggaca
     3901 aacctgcgtg gctccagatt atgttttagt gcatgaagat agaaaaaatg agttaataga
     3961 gaaaataaaa tattatacta ataagtattt tggagataat ccatgtaata atgagcaatt
     4021 tcctaaaatc ataaatcaga gacattttaa tcgaatatta tctcttattg ataaagataa
     4081 gatagtctat ggtggaaatt ataataagga gacattaaag atagagccaa ctatagtaga
     4141 caatgttaat tgggatgata atataatgaa ggaagaaata tttgggccta tatttcccat
     4201 tttaacatat aaagatttgg atgaagtaat acaaaaaatt atacaaatgc caaatccatt
     4261 ggcactttat atttttacaa aaaataagta cctagaaaat aaacttttag aaatgatttc
     4321 agcaggagga tgttgtatca atgatacagt tactcatata gctacgaatt acttaccttt
     4381 tggtggtatt ggtgaaagtg gtatgggctc atatcatgga aaagctggat tcgatacatt
     4441 tactcactat aagagtgtgt taaaaaaatt aaatttggat gtccctatta gatatgctcc
     4501 atacgataat aaattaatta aggttcttaa aaagataatg taggttatat tgtagaataa
     4561 taaatataaa taaaattgag tatttgtatt ctgaatatat tttattttta atttggtata
     4621 tttgttataa aagtggtgat tttgtgataa aatttaatta tatagaaata aggaggaaaa
     4681 aatgaaaatt aattggaata caaaatacac aacaatagca atttatacat ttataatagc
     4741 tgctagtagt attatatttt atctagtatc atcacaaatt gatgtatttt ctaataattt
     4801 agatgctata tttacaacat tacaaccttt tataatagga tttgctattg catatcttct
     4861 taattttatt ttaaagtttt atgaagacag aatttttata aaaagtgaga aattaaaaaa
     4921 actaaaacaa agttcaaaaa gaggcttggg tcttttatta acatatgcaa cagctacatt
     4981 gatactttac ttatttatgc atttcgtatt gccacaagta attgagagta ttgttggact
     5041 agcaaatgat atacctatgt atgtaaacaa tgcaactaag cttattgata aattaatgac
     5101 tgatttaaat cttgatgagc aatactttaa tttagcagtt gataagtgga atgagtttgt
     5161 tacatatatt ataaagtttg taacagattt aatcccaata ttaggaagta tgttaaagaa
     5221 tgtagcctct agtatatgga atattgtact aggattaatt gtttcagtat acttattaat
     5281 tgataaagaa aaattctatg gattaagcaa aaaaataact tatgcagtat ttacagaaaa
     5341 acaagctgct agaattttag aattaactca tagaagtaac tatacatttg gaagattttt
     5401 aggtggcaaa atattagatt cattcattat aggtattcta acatttgtaa tacttacatt
     5461 agttaaaatg ccatatacat tattaatatc agttataatt ggtattacaa atattatccc
     5521 tttctttgga cctttatttg gagctatacc atccacgcta atagtgatgt ttgtatctcc
     5581 tataaaagct ttctggttat tgttaattat attaataata caacagatag atggaaacat
     5641 tataggacct aaaatacttg gagattcaat tggtatatct gcattttgga ttttgttctc
     5701 cttattggtt gcaggaaaat tattaggttt tattggaatg gttataggag ttccaatgtt
     5761 tgcagtaatt tattctataa ttaaggatat tgttgaaagt aaattggaca aaaagggatt
     5821 accgacagat acttccgatt atatgtagct aaaaaatatt atgtataatt aaaaatatat
     5881 aaattaagca atatttaaag cactgagaaa gttaaactct tggtgctttt tagatataaa
     5941 attattatag aagaggtgtt ttttgtggca tttatagaat gtaaatttaa atctaaatat
     6001 actggaggag aaactgatat aattgtaatt ttgcctgtag caaatggaaa agaacttttt
     6061 agtggtaaag agatatatga ttttgaaggt aaatttaaaa cattatactt atttcatggt
     6121 ttagaagatg accaaagctc atggattaga tatactaatg tagagcatta tgctaaaaat
     6181 aaaaatatag ccctagtaat accaagagta gaaactagtt tttataccga tatggcgtat
     6241 ggacaccaat attttacttt tgtaagcgag gaattaccta aatttgttag agctatattt
     6301 cctttatcag ataaaaggga agataacttt gtagctggta tgtctatggg gggatatgga
     6361 gctttaaaat tagcgctttc aaaaccaaaa gagttttcgg cagttgcaag tttttctggt
     6421 tcgcctgata tgattcatga gttagaaaat caacaaatag aaaccaatgc agacattcta
     6481 tttcacgatt ttggtagacc agaagacgct agaaatagtg agaatgattt actttacata
     6541 cttaagaacc ttaaagaaag aaatgaagat attcctaaaa tttatcaatt ttgtggtgat
     6601 agagattttt tatataaaaa taatcagatg tttaaaaaat atgcagattc tctgggtgta
     6661 gatgttgaat atgaagagtg tgtagggggg catgaatggc gtctttggaa tttatggata
     6721 aagaaattta tagatataat tggatagtac acttatggta ttaacaggta tactataaaa
     6781 tatctttaaa tatgataaag actgaaatcc taaaatcaaa ttatgatttt aaaatttcag
     6841 tctctaagaa tttaataaaa ttttattaag ttcttacacg agttattatt ggagtaaaat
     6901 tgtcaactat atctatatag tatttactca attcctctaa aatctcttcg cataaatccg
     6961 tactatgacc aagattaata agaaactgtt ttgtaaaatg ctttattaca gcttgagaag
     7021 atatatcgta cttgtgtgaa gtataaactc taattatttc aggtttcata gcaagtatac
     7081 caatacaaga aagtattaat tcatcatgtt ctatagattc tttatcatta acatatcttt
     7141 tcatgaccat ttcggttaca cttctttgat agcttaaaat agcttcttca taagctatat
     7201 ccaaataaaa atttctatat gcttcgtttt ttagaaggaa acaaaggtca gcattcatag
     7261 caagaaagaa catcatcata gtaccttctt catggtagtt atagattaaa gactgcattt
     7321 catttcttat atcttcatat attatagctc ctatttcgct tttacttgag aagtaatagc
     7381 ttattagacc taaatttata ttagctcttt ctgcaatttg cctagttgtt gtcttatgat
     7441 aaccttgctc aaaaaataat tctctagcag cacttataat actagctttt gtttctttgc
     7501 ccttttctga ttttgacata tttactgtgt atacctctct tttcaatctt tttttgaaaa
     7561 tttgctaact ataaatattg taatagaacc acctattata ggaactaaaa ttctgtcaaa
     7621 tacagtaaga ataccaatca tatttaataa tgccaatata acacttacta taacagcata
     7681 gatagctcct ttttttgtag cacctttcca gcaaagacca attacaaatg gtgcaaatat
     7741 tacacctgta cataatggag ctggccaaaa caataattct aataaactat caaatttaag
     7801 tgctatgatt gcacctatta tagctgtcaa agctgatgca atttgagaat actttagagt
     7861 attttttaaa tcattaaatt ctatattagg atgtaataat ttgttataaa tatctcttga
     7921 tataatagca ctcattgagg tcattaatga atcggcagta gacattatgg cagccaatat
     7981 agcagctaag aataatacag atattaaagg tggcaaagta gtcgatatca tttgaggtaa
     8041 aacctgaaca gatgatatat ttggaaataa actaccacca atagctccaa ttattcctat
     8101 agggaaagca agaaataata gtataaatcc tgcaattaca ctacttttaa ctgcattttt
     8161 agcattatca gcacattgat atcttaaaaa actttcataa gaaaatattg agcctaaaac
     8221 taatggtaaa actgtataca taaaatcact aatcgattta tttcctggaa agaatggttc
     8281 ttttaccatt gattgtaaca taagtaaagg gttgtcgcca actaatttta agcttatata
     8341 agctactatt ggcaaaaaca ctatacaaat agcaagttga ataaatgctg atactgcaac
     8401 tccccacatt cctgatgtat aggtatatat aattataact ataactccta taattacagc
     8461 tatatcataa ggaataccaa atgcagtaga tacagaacca aaagaaatta attgactacc
     8521 cataatagct agtatggata ttggtgttac aagactttga taagctctta aaaatacact
     8581 atgaccatat ctagtttcaa tataatcagc aggtgttata tcacaagata agcttcttaa
     8641 ttttcctgcg aaaaatgcat ttataaagca agctaaagct gcacctatag tagaatacat
     8701 tccaacccaa agtcctcttt cagctcccca ttgaactcca ccaactaagc accctcctcc
     8761 aaaagatgta gcagcaatgg ttgcagctag tataggcaaa ggcagatttc tacctgcgat
     8821 taggaaatcg gatgctgttt taactttttt tgaaaaataa aaaccaatcc atatgtatat
     8881 tgcacacgta acaattaaaa gtaacatagt cttttctcct ttataaaata ttttaataaa
     8941 atatacaaaa tatatttaaa atatatttta tataaaagta gtacgatatt tgttttattg
     9001 gttttagatt aatatagcta taataattta tgatattaga tggaaattac gtaaaaatag
     9061 aaaattgaaa attctgaaat ttttgcatat tgatatttat ctcatagatt cttttttgta
     9121 attgtaacac gcttttattt ttaaatcaat agtacatgta taaaaataaa aggaatttaa
     9181 ataagaaaaa gatattttta atatctggat gtagtataga aatatcttga ataaattatt
     9241 cttgaataaa attataaaaa attaaaatca ctagaaatat gataaaataa tttaaaatac
     9301 gcatttcaat gacatttcaa aacaagaaaa taataaaaaa caaacctaaa ttaagtctaa
     9361 atagcttttt agttaatttt agtagtaaaa aataaaactt aaaaagtatt tgacaattat
     9421 gaattttgag aatataatta aattaaaatt atacacatat aaaaatatat tcctgaatca
     9481 agaatgagat atttaagatt caaaatatat attattatac gtgaataata aaaagtaaga
     9541 aaattttata agggaggggt agatgtgagt agtcaagaaa gcaaaccaaa aggaaatctt
     9601 atatcaaatt ttagagatga tatgagagac cctaagaaaa gagcaatata cacatattca
     9661 agttctataa acttagcgta caattttata ggttactttg tatcaactgt tacaaatatt
     9721 tttttaactg atgtggcaaa acttggtgta attatggcag gtggtatgca aattatacaa
     9781 tctttcataa aaattgctgt agctcctata acaggtacag tatttgacaa acaaccattc
     9841 aaaaaaggaa agtattatcc atggcttaga tatgcaccag cagcgttagc attaacatat
     9901 ggaatatttt tcatagttcc attaatgaaa ataagtccag cattactttt acctttgatg
     9961 acagctttat tattaatagc atcttgtgct cagcaagtag ttttcactat aatttatgct
    10021 atttaccctg tagttgctaa gacacctaga gaccgagtta taggctcaac tactacgaat
    10081 atatttaaag aagttggtaa attcttagta ggtttttcat atccgttatt attagtttta
    10141 tttgcagatg tattaggtgg agaaggaatg ggttatttag gtacctactt attctttgca
    10201 gcaggatgcc ttttagtatt ttggttttct tcaacagaga taataaaatc tggagcagaa
    10261 gaagaagttc ttcaaaaaga agagaagcca aagattaaag caagtgaaat ggcaaaagct
    10321 ttattcacta atgtaccact tatgatggca ttttgtttag aatttcttat atgtataaga
    10381 tctataggat taggaccttt ggctccatat tattttaaat atgtaataga agatgaacgt
    10441 ggattagcag tatttttatc aatcatgcct ttggtaagtg tagcattcat gtttttcgca
    10501 ccagtgttta taaaaatctg tagagagcaa aaactagctt caataatttc tttttctata
    10561 tgtgcactat gccacttatt ggttgcatgg actccttggg ggaaaactac tttaggagta
    10621 actatgttgc tggcaattgg tggaggtttt tcaaatgtag tatcaataat aaatcttaat
    10681 ttctttgccg gttcttgtga ttatgggcat tggaaatcag gaaaagattt gcctggttta
    10741 agtatgtcac tatatccagt tgcaatacaa gtaggagtat tacttgcaac tactataaga
    10801 acagttttaa tgaactcaat gggatatcaa gctgatatgg tagtcacaga agcagttaaa
    10861 tcaggtttta taaatatgat ttcttattct atggcaatac ctttaataat agctgttgtt
    10921 atagcaatac tatatccagt aagtgacaag aaattaaacc aaataagaga agagttaaat
    10981 caaagaaatg cttagttaaa agaaagttaa gtagatggtt aatttaagct attaaagtaa
    11041 gtagacgcaa tagcgtttat ataaatgaaa atacatatac agagggggct tttaaaaatg
    11101 atagaaaaat tattgagaaa taccgtaaaa gaattacatc aatatgttcc aggtgaacca
    11161 atagaaaaag ttaaggaaaa atatggtgta aaagaaataa taaaattagc ttcaaatgaa
    11221 aatcctctag gaccatcacc aaaagcaata gaagctatga ttgaaatgct aaaacaaggt
    11281 caactttatc cagagccaga agctaacgaa cttagaagaa aattagctga aaagctagat
    11341 ttaaaaccag aaaattttat tgttgctaat ggtgcggata acgttatcac tctaataggt
    11401 gaggctttta taaatagagg agatgaagtt atatattgta acccaacatt tccatcatat
    11461 agaactgcaa ctataaaaaa tgaagggata ccagtagaag tacctttaac agaagattat
    11521 aagtatgatt tacaaggtat attagataag attacagata aaacaaaatt aatatgtgta
    11581 tgtaacccta ataatccaac aggaacaatt gtggatgata aagagttaga agaattttta
    11641 aagaaagtcc ctgaaaatat tataactata ttggatgaag catatataga atttttaaca
    11701 gttcctaatt atgtggatgg acttaagtat gtaagggaaa attataacgt tatagtaaca
    11761 agaactttct ctaaaatata tggtcttgca gggcttagag taggatatgg tattgctaaa
    11821 gatgagataa taagaacttt atttacagta aaagagcctt tctctgcaaa tcgtgttgct
    11881 ataagtggag caacagcagc acttgatgat gaagagttta taaaagaaac atatgaatta
    11941 aatagagttg gaatggctta ctttaaagaa gagtttacaa aaatgggatt tgatgttgta
    12001 gattcacaat caaatttcct ttatgtagat atgaaaacag atatacctaa gttatttgaa
    12061 gacttgaaaa aaagagggtt tgtaataaga ccaagtgcta cacatgcacg tgtaagtatt
    12121 ggaactatgg aagaaaatag gaaatttgta gcagttttaa aggaaatatt aaatattaaa
    12181 ggagagccaa gtattggata atagatagaa atattatgaa acggggtgta gatatgaact
    12241 taaaaataaa cgcagagaga tgtaaaagtt gtgaatactg cgttatatct tgtaaaaaag
    12301 gagcattaaa aatatcaagt aagataaata aagaaggtta tgctcatgta gaagttgatg
    12361 agagtaaatg catactttgt ggaatttgct atcaggtgtg tccagataat gtttttgaaa
    12421 taattaaaga agaagcatgt caagaggctt agaaggagtt gggataatat gaaaaagatg
    12481 tggaagggga accacgccat tgcagaagca gccctaagag gaggttgtga attttatgca
    12541 ggatatccaa ttacaccaca aacagaggta atggaatttt tatcacatag aatgtctgaa
    12601 cttggaagaa cttttataca gtccgaaaat gagatggctg ctatatatat ggtatatgga
    12661 gcatatgcaa gtggaatgag gtctatgacg agttcttcag gaccaggaat atctttaaaa
    12721 caagaaggga tttcttactt atgtgcaaat cattaccctt gtgtaatcgt aaatgtacag
    12781 agatgggggc ctggtcttgg ctcattggac tcagcacaga cagactatct aagagatact
    12841 agagggggag gaaatggaga ttatcatttg atagtttatg caccaaacag tattcaagag
    12901 actgtagatt tgatgtataa ctcatttgat gtagcggaga agtacagagt gcctgtcgaa
    12961 attttgacag aagcagcttt aggtcaaatg atggaaccag tagaatttcc agagtttaag
    13021 aagagagaag gagatttagg ttggacttat gatggaagta atagagacca tgcaaaggtt
    13081 gcagataacc aaaagccaac tttttgtatg gagaaacgta tgagaataac tgaaaatgaa
    13141 caacaatggg aagattatca agtagaagat gcagaatatg tgtttgtagc gtttggtata
    13201 ccatcaagaa caactatgaa tgctgttaga agacttagag aacaaggtga aaaagttgga
    13261 ataataagac caataacagt atggcctttc ccatataaag catttgaaaa ggtaagtaaa
    13321 gatgtaaaag gatttatctc agtagaatca acagacacag gtcaattagt agaagatgtt
    13381 gctttagcct caaagaaagt atgtaaagaa aatgtacctg tgtatggttt atttagtgga
    13441 aatcatatac caaaaacatt gcaagtaatg gacacttata gcaaaataaa atctggcgaa
    13501 atcaaggagg tgttctaata tggctacaga aaaattaaca cctagcgttg tttcaatacc
    13561 aaacaagttt tgcccaggtt gtggtcatgg aatagtaaat cgtataatag cagaggtaat
    13621 agaagaacat ggatatgaaa aaaatcatgt attaacatta ggagttggtt gtgtctgcaa
    13681 tatgaatttt agctggaatg gtgataagat gcaaactgca catggtagag cttcatctac
    13741 agctatagga gttaaagtag cacttccaga tacattagta atgacttacc aaggtgatgg
    13801 agatgcttat gttataggtc tttctgaaac tttaaataca gcatatagaa atcataatgt
    13861 gactgtattt gtaataaaca ataataattt tgcaatgact ggtggacaaa tgtcatggac
    13921 cactatgccg ggtcaagtca caacaacaag tgtaaatgga agagatataa agactactgg
    13981 tagtccactg aaagttcctg agatggtggc aaacttcttt gatgtagcat atgtagcaag
    14041 aggttcagtt catagcccaa aggaaataat taatctaaaa aaatatataa aaaatgcaat
    14101 agaagctcaa ttaaatggag agggatattc cttagttgaa atattagcac cttgcccaac
    14161 taactggggt gtatcactag agaaatctat caaatggatg gaagaagaaa tagtgccata
    14221 ttatgctctt ggcgaattta agcaaaggga tggtgaatag ttatggaaaa agagctagta
    14281 tttgcagggt ttggtggtca aggagtttta actcttggtc tgattgtagc tgagtcagca
    14341 cttgaattgg ggaaacaagt aacttggatg cctgcatatg gtccaactat gagaggtgga
    14401 aaagcctata gtgtagtaaa gttttctgat gagagtatag gtgggcctga tatggaagaa
    14461 atagatgttt tagtagcaat gaataaacca tctttagatt atataaattt agttaaagaa
    14521 ggtggaacag tagttattaa tacatctgca atagatgaga atgtaacatt aagagaagat
    14581 ataagtgtag ttaaaataaa ttgtcaggaa ttagctcaaa aagtaaacaa tccaaaagca
    14641 gcaaatatag tagtacttgg agcattaatt gctaaaactg ggttatttga aaaagaatta
    14701 gctttaaaaa ctatgtgtga tttctttgag gaaaaaggaa aaggaaagtt taatgttcaa
    14761 aatgaagcag cattcatgga aggctataat aacgccattt gataaattac ccttatctta
    14821 agtgatttat ctcaagattt aataatcttt agtgccaaga gaaacttcat cttgagataa
    14881 aattcactta aaatcacaac tataaacata taggagcgtg aatttatgag tttggaaaaa
    14941 cttattagac caaaaagtat tgctatagta ggagtgactg ataaacttgg ttttggaaga
    15001 agtgcagcac ttagtatagt aaaaagtaag gaaacagata gagtatatta tgttaatccc
    15061 aaaagagaag aattgtttgg gagaaaatgt tataagacga tacaagaagt tccagaagta
    15121 gtagactgtg tagtagtatg tacgcctaga aatgtagttc catctgtatt aaaagattct
    15181 ggagagttag gaacaaaggc agcagtggta tatgctagtg gatttgcaga ggaaggtaca
    15241 gaggaaggta cagatttaga aaatcaactt atagaaatat caaatacata cgatatgaaa
    15301 atattgggtc caaactgcat ggggttgcta aattgtatag ataaggttaa tctatgggca
    15361 ggaggttcta aatgggattt atatactaaa aaacctggta taggaattgt aggtcaaagt
    15421 ggatttataa ctgctgaaat tgtttcaagt gattatttta atatatctta tggtttttca
    15481 acaggaaatg gaaatatagt tacactagaa gatgcagtag atttccttgt agatgatgat
    15541 tatgcatcag taatagcaat ttaccttgaa ggtttaaaaa atcctcaaaa atttatagat
    15601 gctttaaaaa gggcagcaca aaaaagaaag ccagtaataa tattgaaatc aggaaggtca
    15661 gaaaaaggtg ctatttctgc tgcttctcat acaggaaatt tagctggttc gagtaaagct
    15721 tttgaaagta tttttgaaaa atatggagta atttctgtgg aaaatttaga acagtttatg
    15781 tgtttagcac aagcttttag tgttttagat ggtaatttac ctgcaaattc taattttgca
    15841 gcaataaact tctcaggagg agaaaatact atttgtgcag atttagcaga agaaaatggt
    15901 gtagaacttg cagaaatatc ttctgaaact aaagaagaaa tgaaaaaata tcttccagga
    15961 tttgcaacac ctaaaaatcc actagatgct acaacagcat tattccatga aaaggatatg
    16021 atagtaggtt tattacatac ctttgaaaag gatgatagtg ttggatttac tatggtaggt
    16081 gcaaatataa gagatgaaga aaatgaaatg catgaaaccc tttgtaaagc tgtaagtgaa
    16141 gctagagaac aaggattgaa aaaacctgtg tttgcagttc ctacacttga aggaaataga
    16201 tatttagatt ataggactag attagaagat aatcaagtgc ctataatgtc atcagttgga
    16261 actacattta cttgttttaa taaaatggct aagtttatag attatgatta ttcaaaaaga
    16321 actttagaat ttaaagctgt taagaaaaga gagtcaaata atgtagtagc attatcagaa
    16381 ttagatagta agattgagat gaaaaaatat ggagtaccag ttccaggaca aggtaatgca
    16441 aaaagtattg atgaattaga tgaaatctta aaatatatta agtatcctgt tgttttaaaa
    16501 ataaattctt ctgaaatatt gcacaaatct gatgttggag gagttaaaat aggaattaag
    16561 aatagagatg aggcagtaga tgcatataat gagattttaa ctaatgtaaa aaaagcaaaa
    16621 ccagatgcta atattgatgg tatattagtt caagaaatgg tagaaagtgg tatagaaatt
    16681 attattggta taactaatga tgaccaattt ggaccactgt tattagtcgg tttaggagga
    16741 gtatttgtag aggtatttaa agatactaca ttatatccat tacctataaa tcatgatgaa
    16801 gctattatga tgcttaaaaa actaaaatca tttaagcttt taaatggcta tagaggaagt
    16861 gagccttgcg atattgatgc tcttgcagat atgatggtca aattaggaaa atatgcttat
    16921 gaaaataagg atgaagtcaa ggaaatagac ttaaatccag tgtttgtata tcctaaagga
    16981 aaaggcgtat gtgcagtaga tgccttaata gttaaatata aatagtttat aagttttggt
    17041 attcaaccat aattaaagca ccgactgaaa atcacatttt gtaagttaga tagtgtgatt
    17101 ttcagtcacc ccaaatttaa tttaaaaata ttttaaaatg aaagtatagt tttaagtttc
    17161 attgtgaaat agcactgtat aaacaataaa atactacgta taaaacgaat aataaaaggt
    17221 gttttaatga taagaatcaa tcttgatttt cattaaaaca ccttctttat tatattaaaa
    17281 atttttaaac gttatattgt cacaggtggg tttgttggag ctgcatatgt acgattagca
    17341 aattcttggt caacaaagaa tagaccaccc tctccagcaa gtttaacacg ttttatattg
    17401 tcttcacaat ttgtctcttc ttctgcttgt tcagatataa accaaagtaa gaattgagaa
    17461 gttctaaagt ctgattcaga gtttgctaca gctgctaagt tgtttattaa agctgtaacc
    17521 tttttttcat gagctaacgt acgctcaaga atatccattg cagaagtaaa gtctgaatct
    17581 ggcattggga tagcatcaag ctgaaccttt cctcctacat tatgtaagta tttgtaaaaa
    17641 aacatagcgt ggtctgtctc ttctttatat tgaacataaa accaattaga aaatccttta
    17701 agtccttctg cttcaaggta agaagacata gaaagataaa gatacgcaga atataattca
    17761 tggttaatct gctcattaag taatttttcc attttagctg aaatcatttt tatacctcca
    17821 aattttaaat gctcttataa aatataataa tattaaatgg aaaaatattc aataaaagtg
    17881 tttaaatatt ttacatattt aataaaaatt tatactacca ttaaaaaaat tataacttac
    17941 aatggctata gagccaatta atggtgcatt tgctccaaaa tttgaatgcc ttacacttat
    18001 ttttttatat ttagaaaaac ttgctgaagc agtcaatttt tttaataatg tattttctat
    18061 aaatgtacca ggtatattaa agtcatagcc tattattata gaactacaat caatcaatgt
    18121 aagtgtatta actaatgcat atgatacgta tgtacaaaat tcatcaagca aaaacatggc
    18181 aagactatct ttattatttg cctcatctat taacttgact aaagaaaaat ctttacagtt
    18241 aattaatggg gagttaggat aaatatggct caatgattca attcttttaa ttagattact
    18301 gacacttgta taataatcta aacatccatt gttaccacaa ctgcacaatg gtccactaaa
    18361 attaattgat gtatgtccta tttctccact ttgtcctagg ttgccagtat gaagtttatt
    18421 ttctagaact agaccagctc caataccatt cattatgtgt aggtatatat aatttgatat
    18481 atttttacct aaaccataca ttttttctgc taatgcaccc gaattagcat catttatcaa
    18541 aaatattggc aaatcagaca tttcttttat aaaatctact atatttaggt ttgatatatt
    18601 tccaaaatct gggggattta gtatggtacc atttatatca tctactggac ctattgaaga
    18661 aataccaatt ccaattatat ctctcttgtt gattttcatt attttagtaa acattctttt
    18721 tattatatct tttaaaacat catttgatag acatttaggg taagtttcag aaagttgttt
    18781 tacaatatta ccttttaaat ctgaaataat taccttacat atatttcttc ttattaggat
    18841 tccacaaata caaggcgata tattagaaat atctaataaa atgggtttac gacctgatga
    18901 atgtgcattt aaagttgatg actctatttc cctaatcata ttttcattaa taagttcagt
    18961 aactagattt gataaagtca ttttagtaag tcctgtagac ttagctaaat caactctgga
    19021 cataggtgta tttgtagaaa gtaatttcaa tattattaac ttatttttaa tttttacatc
    19081 tttgatgtta gaaccttgtt tgttactcat cataaatctc cttaaataaa gttaagtgtt
    19141 ttatttattt tcaagtatac tatcacctta taatagagta acattttttt acttgaaaat
    19201 atcattaatt agaatatatc acattatata tcataaaaca tataaaaaaa tattagaatt
    19261 aaattaaaag tgaaaagtag attgatatat aaatagtaaa tacttaatta aaaaaagata
    19321 atgatagcaa taattattgt taccaagaat ctactacttc aagtgttacc ttaggtattt
    19381 aagttgatag tggtttgcac gtaataaact tgatgtaata tatattctta ataatattga
    19441 taaaagattt acttaaaaat aatatagatc atgtaaacat ataatctatt tattgtatac
    19501 aataaaattt cattttgtaa aacagtgaat taaatatgta atatagatat caatttttat
    19561 tacaaattgt tactaaatat aggtacatta gaacaaaaat ctagtaaatt gtaactaaaa
    19621 tgtaaatttt tcctttaatc tatacaatat tatggaaact ttttgtaatt tatgatataa
    19681 taacaaatat ataattatta aattataata aatgactata gcgtagatgt aatactatgt
    19741 tatagtcatt tttgaattaa acttgatata tcaaggggga agaatatgag aacaattaga
    19801 agagttttag cattaggttt aacattagct atatttctaa taaatgtacc taatgtagat
    19861 gcattaacat cagatacaat taaaggtaac aatatatatg agacggctgg attaatagca
    19921 gataaaaaga gttatgatac agcaattatg gtaaatatgg ataattctat agcagatggt
    19981 ctttcagcaa gtggtcttgc aggtgctgtt gatgctccaa ttttgcttgc acaaaaaaat
    20041 aagataccaa atgaaacaaa acaaagatta aaaaatgtta aaaagatata cataataggt
    20101 aaagaattat caataagtaa gtcagtagaa actgaactaa aaaacacagg ggcacaggta
    20161 actagattag gtggagatga cagaataaag actagttata gtgttgctaa agaggtaaat
    20221 ggtatcaaaa aagttgatga agtgatatta actaatgcat ataaaggaga agcagataca
    20281 ataagtgctg cacctgtatc agtaagagat atagctccta tagtacttac agatggaaag
    20341 agtgtgcctt tttcaacaag caatgtaaaa acatatgcag taggtgggag tatatcaatg
    20401 agcactagtt tagttaataa aactaatgct aaaagacttg gtggttcaga tagatatgat
    20461 acaaataaga aagttataaa agagttttat ccagatgcat cagaatttta tttgagtgat
    20521 ggatatgatt tagtaaatgc acttacaggt tctacaattg ctaaggaaaa tccaattgta
    20581 ttggtgtcag aaagtagtga taagtctata ttagcaggag cagataagat tactagatta
    20641 ggttcaataa gtgacagtgt gtataataag tgtgtttctg ctgcacaaaa taatggcgat
    20701 tcgtctacaa aaggtgagtc acctatgaaa aatgagacaa gcatattagg tcagccaaca
    20761 gctagtttag aagcgtgctt aaaatgggca aaatctaaaa aagctaatga tttatttata
    20821 gagttaatac caatattata tgatactgct gttcaggaag gtgttaatcc tgttttggca
    20881 gtagctcaat ctgcaaaaga aactggtttt tgtaattttg gtggagtatt agatgcatca
    20941 tttaagaatc cttgtggact taaaacttct gtaggtggtt ctgatactga taagaatgcc
    21001 cattcaagat ttgatacttg ggaagaagga atattagctc aaattcaaca tttatgctta
    21061 tatgcaggac aagatggtta cccactttca aatccagtag accctagaca tgaaaaatct
    21121 ttatttggta aggctaaaac agttgaaagt ttatctaata attgggctgg aggtcaatat
    21181 ggacaagatt tagtaagaat gatgggagaa attgaggcaa caaaataatt gaagattatc
    21241 aaatatccaa taaataagga ttgattatta tgaaaaagag taatattttt agtatcatat
    21301 ttcctacagt cataatggtg ctaatgtttt taacttttgc tacagatata tttaatattc
    21361 cagatattca atctaaaagt atttttgttg tgggaatggt tttgattttt ccaatctctt
    21421 ttttgataca agggataatt tgtgtattaa ataagactaa ttggatttta tctcttattg
    21481 tgtctttagt aacttatata gtattaatgt atatattttt aaatgattct gcatatatat
    21541 atgttttact ttatacagct ttttatatga ttggacatat aacagctaaa ctctattaca
    21601 aaattaagac ttttaaaaat taaattgaag tatataaaag taacattaag agaagtatcc
    21661 ttaatgattt tctaaaatca gaaataggtg cttctctttt ttgtaaaaat aaaagtatgt
    21721 aaataaaatt taaccattat aattttcttt taacaaatgt atacaataaa cttgttgtat
    21781 aattaagata gataaaataa agggagggat aatatgaatt taatagataa tcatattcat
    21841 actaattttt caagtgatgg aaaggattcc atggaagata caataaaaaa agctataagt
    21901 attggtgtta gatatttgac ttttacagac catttagaac atgatgaaga tagaggattt
    21961 tgcataaatt ataatgacta tgttccagta tttaataagt ttaaagaaaa atataaaaag
    22021 gacatagagt tattactagg tgttgaagtg ggttacagaa aacatctaaa aaatgaaata
    22081 gaagaaataa taaattctaa tccttttgat tttgtattgt gctcaactca tacaattgac
    22141 aatgtacctg ttccatcaaa ggagtatttt aaaggtctta gcaaagaaga tgcgtattat
    22201 aaatatttta atagcatact tgaaactaat cgtgaatttg gagattacaa tatatatggt
    22261 catttggatt atatatctag gtatggaata tattcagata atagagttat atacaatgac
    22321 tttaaagatg ttattgatga ggtcttaaag tcaataatca ataatgggag tggtatagag
    22381 ctaaatactt ctggttatag atatggacta aatgctatac atccaaatga agatattcta
    22441 aaaagatata aagaacttgg aggatttata gttactgtag gttctgattc tcatagggta
    22501 gaagatatat gcaaagattt tgatgtggcc tatgatatgc ttaagtatct tgactttaaa
    22561 tatgtatctt tatttaaaga aagagaaact tattttgtaa atatagaaaa agttaaatct
    22621 aacaatatag cttagagtgt gttttgaagt aaattaatgg atagttaaaa agttaatagt
    22681 tataatattg tatcctctag aaaaatacta gaggttttta ttttgctaaa ataactaaat
    22741 agaattaaat ttaaatagta tagtttattt taaattgaat
//
LOCUS       DAEQCW010000060        22383 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.060, whole genome shotgun sequence.
ACCESSION   DAEQCW010000060 DAEQCW010000000
VERSION     DAEQCW010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22383)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22383)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22383
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.060"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            176..1780
                     /locus_tag="KRO40_002270"
     CDS             176..1780
                     /locus_tag="KRO40_002270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093087.1"
                     /translation="MKEKIYYNGNIITMEDSICGDAILIKDKIIKKIGTKEEVFALKN
                     KDTEIIDLQGKTLMPSFIDSHSHLIAFATTLKLVPLEDATSFKDIVKKIQDFKESNNI
                     KKGDWIIGFSYDNNFLEENKHPDKSVLDSASSENPILISHASGHMGVANTLGLKQLGV
                     TNETRDPEGGHIGRVEGSEEPNGYLEENAFFNVASKIKQPSSNEIFNSIEKAQNIYLS
                     YGITTAQEGLMEENQFNILKAMANQNKLKMDVVGYVNLKKSKSVADNNREFIKKYINR
                     FKIGGYKIFLDGSPQGKTAWLSRPYENSDDGYCGYPIYKDEEVEKFIDISLKEKMQLL
                     THCNGDAAADQLIDAFEKVLNLKEQSSENHIRPVMIHAQTVREDQIDDMKVINMIPSY
                     FVAHTYYWGDIHIKNLGEDRAFKISPLKTTIEKGLIYTLHQDTPVIAPNMLETVWCAV
                     NRITKKGIQIGENEKISPLDALKGVTINAAYQYFEEDKKGSIKEGKLANLIILDENPL
                     TIDPMKIKDIKVLQTIREGEVLYSLK"
     gene            2596..3867
                     /gene="serS"
                     /locus_tag="KRO40_002271"
     CDS             2596..3867
                     /gene="serS"
                     /locus_tag="KRO40_002271"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBH2093088.1"
                     /translation="MLDIKRIRENLDCIKKAMERRGEKDFNLDEVVKLDDERRKILQE
                     VEVMKNELNTASKNIPNLIKEGKDVENEKIKLKELSDKIKVIDQNLKEVEDKMEYLLM
                     RIPNVPHPEVPQGETDEDNVEVRTWGKTTTFDFESKAHWEIGTELGILDFETASKITG
                     SRFTLYKGLGARLERALLNFYLDTNTKVNGYTEVIPPFMANRNSFLGTGQLPKFEEDM
                     FKIEGLDYFMIPTSEVPLTNIHANEILKFEQLPINYTAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVEMVKIVAPEESYNELEKLTNNAETMLQLLNLPYRVVKICTGDLGFTASFK
                     YDVEVWMPSYNRYVEISSCSNCEDFQARRAGIRFKRDKDSKAEYVHTLNGSGLAIGRS
                     VAAILENYQQEDGSVVVPEVLRPYMGVSVIK"
     gene            4147..5652
                     /locus_tag="KRO40_002272"
     CDS             4147..5652
                     /locus_tag="KRO40_002272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH2093089.1"
                     /translation="MKIQNTEWGYIEWKHTYDENNPKQAMNIYIAVTMPGKKHFNHVH
                     YGQEQMIYILEGEGLYIINGVWKPFYQGMIFYIESGSTHETINTGDREIKELIVSNNV
                     DDVGESEVIDINPNNYLKKTLINYSESTLNLYAAVESIRGQFIDPFKIPLIIYDDSWN
                     IVLKNPYFPLFCFEKCNPMKFPQNCDCMNQKSSNQFVCEYGITIYNIPILYKSNSIGV
                     IRGGYVLLSDLNLDTEHNNLYDIPEGAARSIKRLLKQISKNIINFCSFNDIRKDLQEK
                     EKTIARTYHYGEQLEMNLKVAQDMVTNLRINHHFLFNTLNSMASIALDDGSYDLYSAI
                     IDLSRMFRYTMRSDLRFVELESEILYIKNYLNLQKLRYGDALKVKYLIPEKLYNLSVP
                     FNFIQPIVENAFTHGFRDIDTEKRIEIIARLDSQYAIIEIHNNGTILDGNNIDKIKAG
                     IRSNNGHGLSLIYTKFTSAYGNNFDMDIKSSDNEGTYIMIKIPIENYKEYV"
     gene            5766..6464
                     /locus_tag="KRO40_002273"
     CDS             5766..6464
                     /locus_tag="KRO40_002273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH2093090.1"
                     /translation="MRRALIIDDEEAVLKIITHFIEMKDMPIKIVGKATSGDEAVDKI
                     IGLEPDIVFIDIQMPIYNGLEVIEKTSHLSKKINFVVITAFNYFEYAQKALRLNVKDI
                     LLKPLDMKEFTKSVEKIIGYQYTNNDLLNEILEYINLNYSNDLKLNDCARLFLTNPSN
                     ISRIFKSNLNTTFISYLNHIRIEKSIELLENTTKSINEIAEIVGYNSLNNFYKNFKIE
                     KGMTPKVYKLNTKN"
     gene            6749..7837
                     /locus_tag="KRO40_002274"
     CDS             6749..7837
                     /locus_tag="KRO40_002274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093091.1"
                     /translation="MSDKVNMKNIICIAGAYLATAIGSGFATGQEILQFFASQGYMGL
                     IGALISMVLFSFLGAEVITRGRELKLKEPTRIYTFYCGKILGKFYEWFSPIFLFGILI
                     VMISGAGSTLTEYYGINPYLGRVLMAVATLITVSMGLEKLVSILGRIGPVIAVFTIAV
                     GLISLFKHFDGLSMVGEAMKNIEVTKASESPIVSGVIYNTLNIIVMIVFLTGMGASIE
                     SKKDAFWGGLLGGIVFMTAGIVMYLAMISDIGNLYMKEIPSLYLADNISPIVGVCFSV
                     ALILGIYTTAVPLLWSVTNRIVEDEHPKFKLVTTVIAILACIGGFLPFGKLVNILYPY
                     TGYMGLLILVCMVYKAITCRKKSTQSQE"
     gene            8076..9266
                     /locus_tag="KRO40_002275"
     CDS             8076..9266
                     /locus_tag="KRO40_002275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093092.1"
                     /translation="MHELILISEKYKEDILDFFTDIHMHPELSFKEFRTTKAIKDLLV
                     SLDIEILDLGMETGVVGLLKGKYDGPTVALRGDIDALPIYEEVDIKYKSRYDGIMHAC
                     GHDIHTSCLVGCAYVLSHIRDSLHGNVKFIFQPAEEVNKGAKMLVERGVMENPKVDAI
                     FGLHNHPDIPCGKIGVKLGGLMAAVDTIKIEVNGFGGHGGIPNRTIDPIVASSAIIMG
                     IQTIVSRNISPLESAVISIGTINGGTANNVISEKVDMTGTCRSFSNEVRKKISENLEN
                     IVCEIARGYQATAKLDYLFDLPAVINSKEMYAIACKSVCDLYSEDAIVDPIPSTGGED
                     FSIFMEKAPGFFYWLGVGNKEQDCIYQWHNPKFKADKNSILVGTNVLCQSVINYMDKL
                     KNKI"
     gene            9357..10859
                     /locus_tag="KRO40_002276"
     CDS             9357..10859
                     /locus_tag="KRO40_002276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBH2093093.1"
                     /translation="MRALNVVERAGNKLPDPVTIFLLLCIIVVILSAVISNLGVEEIH
                     PSTKEVVKVVNLLEKEQIQSYLGSIVTNFQSFAPLGLVLVTMLGAGVAEKSGFMEVLM
                     KKGISKVPQKLVTVAIVFAGMLSHTAADVGFIILPPLAALVFLGIGRHPLVGMFAAFA
                     GVAGGFAANVMLSTTDVLLAGFTIPAAQMMDPSYQGNPAMNLYFAFISAIVLTFAGAF
                     VTEKFIAPRFTKYNDSTNDKDIQELSELENKGIKYALLSLLVVVVVIVALCIGDNAFM
                     KDPETGSILSSNAPLMKGIVPIITIIFLTPGLVYGKVSKKIKSDKDLVSMMGSSMSDM
                     GGYIVLAFIASQFINLFNLSNLGTILSITGAKLLAESGIPSYGLIIGFILLSGFINLF
                     VGSASAKWAILAPIFVPMFMLLDFNPALTQIAYRIGDASTNPISPLFPYFPVILAFAR
                     RYDKDIGIGTVISNMIPYSVVFTLIEIIILLLFMGIGIPLGPGGGISYVL"
     gene            10931..12187
                     /locus_tag="KRO40_002277"
     CDS             10931..12187
                     /locus_tag="KRO40_002277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBH2093094.1"
                     /translation="MLKTTKISDPELYKIVADELVRQEHNIEMIASESTAPTEVLELS
                     GCVFTNKTEEGYPGARFQAGSEEADKLETLAIKRAKEVFGAEHVNVQPYSGSTANYCV
                     YSSILKPNDTVLSMRLDQGGHLTHGSAVNFLHDIYKYEFYGVDPNTGRIDYDALEAKA
                     KECRPKLIIAGASSYPRLIDYERISKVAKEVGAYFMVDMAHVAGLVAAKVIPSPVPYA
                     DFVSSSTTKTFCGPRSGIVLCKAEHAKKLDKGVFPGTLGSIHLNTVAAKAFSLLYLST
                     DKFKKIMEQVVVNAQTLASELISHGFSIVSGGTDNHIVMVDLRSKNLTGKQFEKALEY
                     VGITVNKNVIPDDPQSPFVTSGVRIGLTSISQRGLKEKEVIQIAGIMNKVAENIDNKE
                     VLDECKAEAQELISKFPLYPEGYFED"
     gene            12359..15133
                     /locus_tag="KRO40_002278"
     CDS             12359..15133
                     /locus_tag="KRO40_002278"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBH2093095.1"
                     /translation="MRYYNKPTKEVLKYLKTNPEIGLDDNEVEERKLRYGLNEFTIKE
                     GRTFWDELGESLTEPMILILIGAAVISSFVGELHDALGILGAIFIGISIGIITEGKSK
                     KAAHALSKLTENIEVKVLRNGKIIKISKNDLVPGDIVYIETGDMIPADGRLIQSINLK
                     LREDMLTGESDDVAKNADAVLDMEVVYSKTEIIEQDAIPAKQVNMVFGGTLVAYGRGI
                     MVVTHTGDKTEMGKIAQNLSNEDQQTPLQIKLGKLGAKIAGISGVIATLLCMFMIIQM
                     QRKGMLILDTSSVLSFLQSLEPAKNAYMVCIALIVATVPEGLPTMINITLAITMQKMA
                     KINALVTKKEACETIGSVSVICSDKTGTLTQNKMMVEVAYVDGKYISGGEYQSNSYFE
                     QNCIVNSTADIEKEDNSFKYIGSATECALLLYHNDKNYNEMRKQTYLISQIPFSSEEK
                     KMSTLIRQEDSDILLSKGAPEVLLKKCSYVQQGKNIVPITPKVEKSILDEIKKLQIKS
                     MRTLGFAYKKMSNSKTEVAVTSEGELNLIGNSRSYMKEDNLVFSGFVGIVDPLREGVK
                     DSIDKAFNAGVDVKMLTGDNINTATAIGNELGLLNDGKKAVEATYIDVLTDKELREEI
                     KGISIVARSKPDTKMRIVSALQKSGEVVAVTGDGINDAPALSQADVGIAMGISGTEVS
                     KNAADIILTDDSFSTIVEGIKWGRGIYENFQRFIQFQLTVNIVAFIIAIISQLTGKDM
                     PFTTIQLLWVNIIMDGPPALALGLEPVRDYVLKRKPINRHSGIIARSMFVNIIINAIL
                     IITIVFTQSAFNILGATSEEQGTVIFSLFAFSALFNALNCREFGLNSTIPNFFKNKLA
                     LQIIVVTGIIQIIFTQVFQSFFNSVSLDFDMWIKIILFASTILLSNEFVKLILRTMKN
                     SRTMNFNSKN"
     gene            complement(15234..15383)
                     /locus_tag="KRO40_002279"
     CDS             complement(15234..15383)
                     /locus_tag="KRO40_002279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBH2093096.1"
                     /translation="MFFISYIYTKSPIEFDTPLQKEAYKILQKLDIDFECVDTDEAIT
                     MEDCV"
     gene            15758..16936
                     /locus_tag="KRO40_002280"
     CDS             15758..16936
                     /locus_tag="KRO40_002280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH2093097.1"
                     /translation="MFSKILVKTFIRDSENVQNTDVRNKYGYVAGVVGILSNLLLFVI
                     KVFIGMLTSSIAIMADAFNNLSDMASSAITMIGFKLASKPADKEHPFGHGRIEYLSAL
                     IVAFMVMLVGLQFVKSSIERIVNPIPVKFEVIPLILLIASIMIKIWLSRFNKFMGNKI
                     DSSALKAVSLDALGDVFTSSCVVISFIVARFTNFPIDGYVGIVVSLVILYAGFSLVKD
                     TINPLLGEAPDEEMVNSIIELLLSYKYIIGTHDLIIHNYGVGRCIASIHAEIPSNIDI
                     MEIHEIIDTAEREISEKLDIYLVIHMDPICLEDKEVMSAKKELEEILKKNSLVKSMHD
                     FRIVGKGSKKNLIFDIVVNPSEFSKNMSEDDLKEDITKLVKEINPEYNCVIVVDKDFI
                     "
     regulatory      17063..17148
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            17266..20184
                     /locus_tag="KRO40_002281"
     CDS             17266..20184
                     /locus_tag="KRO40_002281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021362860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH2093098.1"
                     /translation="MKKGNRKALLISLIMILSMVVSTIYPTVSYASELGENSQIQSGS
                     TNSSTGEEKESDNKKPEQTPEKDKATDNKKPEQTPEEEKPTDNKKPEQTPEEDKSTDN
                     KKPEQTPEGEKPIDNKKPEQIQEEDKSTDNKKSEQALEDEKPLDNKNTEKTPEEDNLL
                     EDENLLKVLEEELNEENEDYGFVVKINNNTIETESMKKISFNLTYTPTSKGIQAGDSI
                     TFKVPDVFNKVNLDYTSECFDKTESNGEYTLTFRELPNGQSVMQGKIGLEAYVKKVDE
                     DTNAKIHIETTGKIESGSGDIDVEIKPGDKTDVPDAKGTLKKLVEGKKSTTVFMPVKN
                     KDINYSIQVNEKQEELKDIILYDELPEGLTLINGSVSVVTSDGKEVSDFNIEQSKNSI
                     SVNFGNIDKSYTVKYKARISDKNAKHGNKYKNVARIESDGKKIQEDDATVSIFDRGDD
                     YLLTKGHSGATNITQVGQVINYQISINDDKSPISNVVITDNIPEGMRLTTSGEAGHDF
                     RVVEIPMNGSWTPWSKEKIANNISYKVEEKRNESGQVDKVITGFTINLSKEEVESKFF
                     IAYTLKVISIEDSYINRAVLDANNSEIDKNDEINFKKNSGLISAKKEVDKKVLNSSDN
                     QIVKYKINMSTYGVYDAGQVNLLDEVNSVLEISNIKYSDNLELKKEAGDGKNTIRLVN
                     KYEFKQIKEGEPVQSWVTFDANFTNVKVGETIRNVAQINGSSPPGVETTKQGYAFEAK
                     KVDALDKNVLSGAKFNLEDAFGNIVVKDLVSDEDGIIQSSVKNPGTYYLVEIMAPRGY
                     EKLKDKVKVEIGNEDIGKIVDIGNIENLKQENPPVNPPIPPDTDEPIVNPPVPPSTDK
                     PRKPSSSSDTENTIVINPPVPPSEDIINPPIPEVLNPPVPPSEEMIETPVKQIIPIPE
                     VVKPSVSEEKNNKVKDDTLVNPPVPPKTGDSTTIIGEILLVIGAIVGLIVLRRNKNTN
                     "
     regulatory      20369..20454
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            20554..21216
                     /gene="zmp1"
                     /locus_tag="KRO40_002282"
     CDS             20554..21216
                     /gene="zmp1"
                     /locus_tag="KRO40_002282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease Zmp1"
                     /protein_id="HBH2093099.1"
                     /translation="MRPSKKLLIAIISIFLISSVPVSAHADSTTIQQNKDTLSQIVVF
                     PTGNYDKNEANAMVNRLANIDGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKG
                     WEGTGKTWDDVPGLGGSTVALRIGFSNKGKGHDSINLELHETAHAIDHIVLNDISKSA
                     QFKQIFAKEGRSLGNVNYLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNL
                     AK"
     gene            complement(21338..22300)
                     /locus_tag="KRO40_002283"
     CDS             complement(21338..22300)
                     /locus_tag="KRO40_002283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH2093100.1"
                     /translation="MKKGYVYIILTTLFFSSMEISLKTVTNDFNPLQITLSRFFVGGL
                     VLLPFAVKRLRALSLSITKSDLKYFAFLGFMCVVVSMSLYQLAVLNTKASVVAVLFSC
                     NPVFVMLLAYLILKEKIYRHNVISLILEVLGIIVIINPLHTKLTLSGIFLTLSSAIIF
                     SMYTVFGKRKTLKFGGIVVTCFSFIFGSLEMLILVLLTKINFIADILNKNKLHVFANI
                     PIFSGYTLHNMPIMIYVFVFVTGVGYALYFMAMEATSTSLTSLVFFFKPVISPILALL
                     ILKEIIPINMVIGILLIVIGSIISIIPTIITQMHNKHVEALYKE"
BASE COUNT         8963 a         2519 c         3874 g         7027 t
ORIGIN      
        1 gcctattaat ttgtcttatt tacaatgaat agtatttact tcttggcaaa caataattaa
       61 aaataaaact tttatatgat taaactctaa agaaaaagtt tataaagaag ataatataat
      121 taagcagaaa ataatgaaaa aaatttatta aagtagacaa cgtaaggaga attttatgaa
      181 agaaaaaatt tattacaatg gaaatatcat cacaatggaa gattcaatat gtggagatgc
      241 tattcttata aaagacaaaa taataaaaaa gataggaaca aaagaagaag tatttgcttt
      301 gaaaaataaa gatacagaaa ttatagattt acaaggtaag acattgatgc catcttttat
      361 agattcacat agtcacttga tagcttttgc tactactcta aagctagttc ctttagaaga
      421 tgcaaccagt tttaaagaca tagtaaaaaa aatacaggat ttcaaagagt cgaataatat
      481 aaaaaaagga gactggataa ttggattttc atatgataat aattttttag aagaaaataa
      541 gcatccagat aagagtgtac tcgatagtgc atcttcagaa aatccaatac taatttcaca
      601 tgcttctggt catatgggag ttgcaaatac attggggtta aaacagcttg gtgttaccaa
      661 tgaaacacgt gacccagaag gtggacatat aggtagagta gaaggcagtg aagaaccaaa
      721 tggatattta gaagaaaatg cattttttaa tgtagcatct aaaataaaac aaccatcatc
      781 aaatgagatt tttaattcaa ttgaaaaagc acagaacata tatctaagtt atggtattac
      841 aacagctcaa gaaggtttaa tggaagaaaa tcaatttaac attttaaaag caatggcaaa
      901 tcaaaataaa ttaaaaatgg atgttgtagg atatgtaaat ttgaaaaaaa gtaagtctgt
      961 agcagataat aatagggagt ttataaaaaa atatataaat agatttaaaa taggaggtta
     1021 taagattttc ttagatggtt ctccacaagg taagacagca tggttgagta gaccatatga
     1081 aaattcagat gatggttatt gtggatatcc tatatacaaa gatgaagaag tagaaaagtt
     1141 tatagatatt tcactaaaag aaaagatgca actcttaact cattgtaatg gagatgcagc
     1201 agcagaccag ttgatagatg cgtttgagaa agttttaaac ttaaaagagc aaagtagtga
     1261 aaatcatata agaccagtta tgatacatgc tcaaacagta agagaagacc agattgatga
     1321 tatgaaagta ataaatatga taccttcata ctttgtagct cacacatatt attggggtga
     1381 tattcatatc aaaaaccttg gagaagatag agcgtttaag attagcccac ttaaaacaac
     1441 tatagaaaag ggattaattt acactcttca tcaggataca ccagtaatag cacctaatat
     1501 gctggaaaca gtatggtgtg ctgtcaatag aattacaaaa aaaggtatac aaataggaga
     1561 aaatgaaaag ataagcccat tagatgcttt aaagggtgtt actataaatg cagcatatca
     1621 atattttgaa gaagataaaa aaggttcaat taaagaaggg aaattagcta atttgataat
     1681 attagatgaa aacccactta caatcgaccc tatgaaaata aaagatatta aagtattgca
     1741 gactataaga gaaggagaag tattgtattc tttgaagtag atgaaagtta gatattttat
     1801 aatctataaa aaatagtttt atataataag ttaggtagaa ttaaataaga ttacagttaa
     1861 atcaacaatt atatttttat taaattttaa ttattgtatt gaagatttat aagtataatt
     1921 ttattgattc taccttttta aataactgta gatttattaa agttatctat gtactatatt
     1981 aaacaattaa gtagttatta attgcactta ttagtttatt aaaaaactat gtatattact
     2041 ttgcagtaag actttggaac taaatctata atagcaaatt taaatttatt aaatagatta
     2101 ccttataaca tttcatataa aatatattgt gaatctgaga aaattactat ttttctttga
     2161 gtattttttg taagcagttc taaaagattc aatttcatac ctattacttg aatcattcat
     2221 taaaataatt ctaatttaaa aaataattct atccaaataa tagatatata ggactatgtt
     2281 ataatataaa aaaatttata taaaagttaa taactatata agattgataa agaaaaagtc
     2341 aaaatagata attgattagc aaaatagata taattataat gaagttaaat ctagcaatat
     2401 tctcctaaaa ttaaatttca tttatttaat taaatataat ttgacaatgg gcaaaaaagt
     2461 gagtaaaata taaataaaat aaaaataaca ggttcggata aagaaaaagg tttcttaacc
     2521 tcaagcataa agtatattat ctaagttatt tgagattaag agataaatcc aatcttaagt
     2581 actgaggagg aaaaaatgct tgatataaaa agaataagag aaaatttaga ttgtataaaa
     2641 aaagcaatgg aaagaagggg cgaaaaagac tttaaccttg atgaagtagt taagttagat
     2701 gatgaaagaa gaaagattct tcaagaagtt gaagttatga aaaatgaatt aaatacagca
     2761 tctaaaaata taccaaatct tataaaagaa ggtaaagatg tagaaaatga aaagattaaa
     2821 ctaaaagagt tatctgataa aattaaggta atagaccaaa atcttaaaga agtagaagat
     2881 aagatggaat acctattaat gagaatacca aatgtaccac atccagaagt accacaaggt
     2941 gaaactgatg aagataatgt tgaagtaaga acttggggaa agactactac ctttgatttt
     3001 gaatctaagg ctcattggga aattggaaca gaattaggta tacttgattt tgaaacagct
     3061 agtaaaataa ctggttcaag atttactctt tacaaaggtt taggtgctag attagagaga
     3121 gcattattaa atttttactt agacacgaat acaaaagtaa atggatatac agaagttatt
     3181 ccaccattta tggcaaatag aaatagtttt ttaggtacag gacagttacc taagtttgaa
     3241 gaagatatgt ttaaaataga aggtctggac tattttatga ttccaacatc agaagttcct
     3301 ttaactaata tacatgctaa tgaaatactt aaatttgaac aattaccgat aaattataca
     3361 gcttatactc catgttttag gtcagaagct ggttctgctg gaagagatac aagaggttta
     3421 gtaagacagc atcagtttaa caaagtagaa atggttaaaa tagttgcacc agaagaatct
     3481 tacaatgagt tagaaaagct tactaacaat gcggaaacta tgctacaatt attgaatctg
     3541 ccttataggg tagtaaagat atgtacaggt gatttaggat ttacggcttc ttttaaatat
     3601 gatgtagaag tttggatgcc aagttacaat aggtatgttg agatttcatc ttgttcaaac
     3661 tgcgaagatt tccaagctag aagagcagga ataagattta aaagagataa agattctaaa
     3721 gctgaatatg tacacacatt aaatggctct gggttagcta ttggaagaag tgttgcagct
     3781 atattagaaa attatcaaca agaagatggt tctgtggttg ttcctgaagt tttaagacca
     3841 tatatgggag tttctgttat taaataagag ttaaattatg tatttttaag caatacaata
     3901 atatagaggt aataaaaaat aattaatata aaagtgatac ttctaatata gaagtaataa
     3961 aaaaatagtt aatataaaag tgatacaata ataatagaag taataaaaaa aaataattaa
     4021 tataaaaatg tgtacaaact aatgaatatt gatatagtaa gctatcatat gaaagagtat
     4081 gtacacattt tttttactaa tttttcacaa tatgaacata aataatttac aggaaaggaa
     4141 tcttttatga aaattcaaaa tactgagtgg ggatatattg aatggaaaca tacttatgat
     4201 gaaaataatc caaaacaagc tatgaatata tacattgcag taactatgcc tggtaagaaa
     4261 cattttaatc atgttcatta tggtcaagag cagatgatat atattttaga gggagagggt
     4321 ttgtatatta taaatggagt ttggaagcca ttttatcaag gtatgatttt ttatatagaa
     4381 tctggtagca cacatgaaac tataaataca ggtgatagag aaataaaaga acttattgtt
     4441 tcaaataatg tagatgatgt aggagagagt gaagttatag atattaatcc taataattat
     4501 ttaaagaaga ccttgataaa ttatagtgaa agtacattaa atttgtatgc agcagtagaa
     4561 tcaattcgtg gtcaatttat agacccgttt aaaattccat taattatata tgatgattca
     4621 tggaatatag ttttaaaaaa tccttatttt ccactttttt gttttgaaaa atgtaatcct
     4681 atgaaatttc ctcaaaattg tgattgtatg aatcaaaaaa gtagcaatca atttgtatgt
     4741 gaatatggga taactatata taatatacca atactgtaca aaagcaatag cataggtgtt
     4801 ataagaggag ggtatgtact attatctgat ttgaatttag atacagagca taataattta
     4861 tatgatattc cagagggagc tgctagaagt ataaaacgcc tcctgaaaca aatatctaaa
     4921 aatataataa atttttgctc ttttaatgat ataagaaagg atttacaaga aaaagagaag
     4981 actatagcaa gaacatatca ttatggagag caacttgaaa tgaatttaaa agtagctcaa
     5041 gatatggtta ctaatttaag aataaatcat cactttttat ttaatacatt aaattcaatg
     5101 gcaagcatag cgctagatga tggtagttat gatttgtata gtgcaataat agatttatca
     5161 agaatgttta gatatacaat gaggtctgat ttaagatttg tagaattaga atctgaaata
     5221 ttatacatta aaaattattt gaatttacag aaattacgtt atggagatgc acttaaagta
     5281 aaatatctta ttccagagaa gttatataac ctttctgtgc cttttaactt tattcaacct
     5341 attgtagaga atgcatttac acatggattt agagatattg acacagaaaa gcgaattgaa
     5401 ataattgcaa gattagattc tcagtatgct attatagaga ttcataataa tggaactatc
     5461 ttagatggaa ataatataga caaaataaag gcaggtattc gtagtaataa tggtcatggt
     5521 ttgtctttaa tatatacaaa attcacatct gcttatggaa ataattttga tatggatata
     5581 aagtcgagtg ataatgaagg aacttacata atgattaaaa ttcctattga aaattataag
     5641 gaatatgtat agaacttgtg aaaaattaat aagttttata aatgttaaga aatatattag
     5701 atgtttttat gttgttttat atatcttact tttttatatt attaagctaa aagggaggta
     5761 ttctcatgag aagagcacta ataatagatg atgaagaagc tgttctaaaa ataataacac
     5821 attttataga aatgaaagat atgccaataa aaattgttgg taaagcaaca tctggtgatg
     5881 aagcagtaga taaaatcatt ggtttagagc cagacatagt ttttatagat attcaaatgc
     5941 caatatacaa cgggttagaa gtaatagaaa aaacatctca tttatctaaa aaaataaact
     6001 ttgtagtaat aactgcattt aactattttg aatatgctca aaaagctttg agattaaatg
     6061 taaaagatat actccttaaa ccattggata tgaaagaatt tactaagtct gtagaaaaaa
     6121 ttattggata tcaatatacc aataatgatt tattaaatga gatactggaa tatataaatc
     6181 taaactatag caatgactta aagttaaatg attgtgctag attattttta accaatccat
     6241 ctaatatatc taggattttt aaaagtaatt taaatacaac ttttatatca tatctaaatc
     6301 atataagaat agaaaaatct attgagttac ttgaaaatac tacaaaaagt ataaatgaga
     6361 ttgcagaaat agttggatat aatagcctaa ataactttta taaaaacttt aagatagaaa
     6421 aaggaatgac tccaaaagtt tataaactga acactaaaaa ttgaaattga taaataaaaa
     6481 gtcaatatag ataattgttt gagtgtgtct gaataagtat actttaatta tgataaaaat
     6541 taaagcgctt taaacatatt taataatatt aaaccttata aaagctgtac ctatttatat
     6601 aaaaaaatat atataaataa aaagaaaaag atatacaaaa taaaaaaagt gaattaaata
     6661 ctgttttaaa aatacagaat tttcatttaa ttcactgaga gtttatattt cttaaaggaa
     6721 ggtaacttta taatggaggt aatttaatat gtcagacaaa gtgaatatga aaaatattat
     6781 ctgtattgca ggcgcttatc tagcaacagc aattggttct gggtttgcta ctggtcaaga
     6841 aattctacaa ttttttgcct cacaagggta tatgggttta attggagcat taatatcaat
     6901 ggtattgttt tcatttcttg gtgctgaagt tataactaga ggtagagaat taaaacttaa
     6961 agaaccaaca agaatttaca ctttttattg tgggaagatt ttaggaaaat tttacgaatg
     7021 gtttagtcca atatttttat ttgggattct tatagtaatg atttcaggtg caggctcaac
     7081 tttaactgaa tactatggta taaatcctta cttaggaaga gtattgatgg ctgttgctac
     7141 tttaattaca gtgtctatgg gtttagaaaa attagtaagc atacttggac gtattggacc
     7201 agtgatagca gtatttacaa ttgctgttgg attaataagc ttgtttaagc attttgacgg
     7261 tttatctatg gttggagaag ctatgaaaaa tattgaagtt acaaaagcat cagaaagtcc
     7321 aatcgtttct ggtgtaatat ataatacatt aaatattatt gtaatgattg tttttttaac
     7381 aggaatggga gcttctattg aaagtaaaaa ggatgctttt tggggaggtt tattaggtgg
     7441 aatagtgttt atgactgctg gtatagttat gtatttggct atgatttcag atataggaaa
     7501 tttgtatatg aaagaaatac catcacttta tttagcagat aatatatctc cgattgtagg
     7561 tgtatgtttt tcagttgcat taatattagg tatctataca acagctgttc cacttttatg
     7621 gtctgtaacc aatagaattg ttgaagatga acatcctaaa tttaaattgg taacaacagt
     7681 aatagctatt ttggcttgta taggaggttt tttaccgttt ggtaaattag taaacatttt
     7741 atatccatat acaggttata tggggctttt aattttagtc tgtatggtgt ataaagcaat
     7801 tacatgtaga aaaaaatcaa cacaaagtca ggaatagagc cacttattaa tagtttttat
     7861 ttaaagaaat tttttatata atccgaattt aaaaagtcaa aatagttaaa taaattgcaa
     7921 aacatgataa tatatttaat taaaataata tagtaaaatg taaatataaa ctaaaattaa
     7981 atttataaaa aatatcttta taaagattat taacttatat aatttgtagt taaattataa
     8041 aaaataaaaa aataaaattt tggagaggtg ttagtatgca tgaacttatt ttaatctcag
     8101 aaaagtataa agaagatatt ttagattttt ttacagatat tcatatgcac cccgaattaa
     8161 gttttaaaga atttaggact acaaaagcta taaaagattt attagtaagt ttagacatag
     8221 aaatattaga tttaggaatg gaaacaggag ttgttggatt attaaaaggg aagtatgatg
     8281 gtcccacagt agcactaaga ggagatattg atgcattgcc aatatatgaa gaggttgata
     8341 ttaagtataa atccagatat gatggtataa tgcatgcatg tgggcatgat atacacacgt
     8401 cttgccttgt aggatgtgca tatgtattgt ctcatattag agatagtctt catggaaatg
     8461 taaagtttat atttcaacca gccgaagaag tcaataaagg tgcgaagatg ctagtggaac
     8521 gaggagtaat ggaaaatcca aaagttgatg ctatatttgg acttcataat catccagata
     8581 taccttgtgg aaaaataggt gttaagttag gtgggttaat ggcagcagta gacactatta
     8641 agatagaagt aaatggattt ggaggtcacg gaggtatacc aaacagaaca atagacccta
     8701 tagtagcatc aagtgcaatt ataatgggta ttcaaaccat agtaagcaga aacataagtc
     8761 cattagaatc agctgttata tcaataggta ctataaatgg agggactgca aataatgtaa
     8821 tttcagaaaa ggtagatatg acaggcacat gtagaagctt tagtaatgaa gtacgaaaga
     8881 aaatatcaga aaatttagaa aatatagttt gtgagatagc tcgtggatat caagcaactg
     8941 caaagctaga ttatttattt gatttaccag ctgttataaa tagtaaagag atgtacgcaa
     9001 tagcttgtaa gtctgtgtgt gatttgtatt cagaagatgc tatagttgat ccaatacctt
     9061 ctacaggagg agaagatttt tctatattca tggaaaaagc cccaggattt ttttactggt
     9121 taggggtagg caacaaagaa caagattgta tatatcagtg gcataatcct aaatttaaag
     9181 ctgataaaaa ttctatattg gtaggtacaa atgtactatg tcagtctgtt ataaattata
     9241 tggataaatt aaaaaataaa atttaagata aagcattctg gagataaagt ttatgagggg
     9301 gtattagttt gaggaaaatt aattcacagg aaaaaaacaa agatagtgga ttattgatga
     9361 gggcactaaa tgttgtagag agagcaggaa ataaacttcc agacccagta accatatttt
     9421 tattactatg tataattgtt gtaatattgt cagcagttat atctaattta ggagtagaag
     9481 aaatacatcc ttctacaaaa gaagttgtaa aggtagtaaa tctactagag aaagagcaga
     9541 ttcaatcata tttaggtagc atagttacaa acttccagtc atttgctcct ttaggattag
     9601 tactggttac aatgcttgga gcaggtgttg ctgagaaatc tggatttatg gaagtgttaa
     9661 tgaaaaaggg tataagtaaa gttccacaaa aacttgtaac tgtagcaatc gtatttgcag
     9721 gtatgttatc acatacagca gcagatgtag gatttataat attaccacca cttgcagcac
     9781 ttgtgttttt aggaattgga agacatcctc ttgtaggtat gtttgcagct tttgcaggtg
     9841 ttgcaggggg atttgcagca aatgttatgc ttagtactac agatgtattg ttagctggat
     9901 ttacaatacc agcagctcaa atgatggacc catcttacca aggcaatcca gcaatgaatc
     9961 tttattttgc ttttatatca gcgatagttt taacttttgc aggagcattt gtaactgaaa
    10021 aatttatagc tcctcgtttt acaaaatata atgattcaac aaatgataag gatatacagg
    10081 aattgagtga acttgaaaat aagggtataa aatacgcttt attatcattg ttagttgtag
    10141 tagtagtgat agttgcctta tgtataggtg acaatgcatt tatgaaagat ccagagactg
    10201 gttctatact atctagtaat gcacctttaa tgaaaggtat agttcctata atcactatta
    10261 tatttttaac tccaggatta gtgtatggaa aagtaagtaa gaagataaaa agtgacaaag
    10321 atttagtatc tatgatgggt agtagtatga gtgatatggg tggatatata gtcctagcat
    10381 ttatagcatc ccagtttatt aatttattta atcttagtaa cttaggaaca attttatcaa
    10441 taacaggagc aaaattacta gcagagtcgg gaatacctag ctatggattg ataataggat
    10501 ttatattgct atctggattt atcaatttat ttgtaggaag tgcttctgca aaatgggcga
    10561 ttttagcacc tatatttgtt cccatgttta tgctactaga ctttaatcca gcattaactc
    10621 aaatagctta tcgtattgga gatgcttcaa caaatccaat aagtccactt tttccgtatt
    10681 ttccagttat attggccttt gccagaagat atgataaaga tataggtata ggtactgtca
    10741 tatcgaatat gattccatac tcagtggtat ttacattaat agaaataata atattgttac
    10801 tattcatggg tattggcata ccattaggac ctggtggagg aatatcttac gttttataga
    10861 ccattataat aaatttatca atgaagatta aactaataaa atatattctt taattaagag
    10921 gaggattatt atgttaaaaa caacaaaaat ttcagaccca gagttataca agattgtagc
    10981 tgatgagttg gttagacaag aacacaatat tgagatgata gcttctgaaa gtacagcacc
    11041 aacagaagta cttgaattaa gtggatgtgt atttacaaat aaaacagaag aaggctatcc
    11101 aggggctcgt tttcaagcag gttctgaaga agcagataaa cttgaaaccc tagcaataaa
    11161 acgtgcaaaa gaagtatttg gagcagaaca tgtaaacgta caaccgtatt caggttctac
    11221 agctaactat tgtgtatatt catcaatatt aaaaccaaat gacactgttt taagtatgcg
    11281 tcttgaccaa ggtggacact tgacacatgg tagcgcagtt aattttttac atgacattta
    11341 taaatatgaa ttttatgggg tagacccaaa tactggacgt atagattatg atgctcttga
    11401 agcaaaggca aaagaatgta gaccaaaact tataattgca ggggcaagtt catatccaag
    11461 attaatagat tatgaaagaa tatcaaaggt tgcaaaagaa gtaggagctt actttatggt
    11521 agatatggca catgttgcag gattagtcgc agcgaaagta atacctagtc ctgtacctta
    11581 tgcagatttt gtttcttcat ctacgacaaa gactttctgt ggaccaagaa gtggtattgt
    11641 actttgtaaa gcagaacatg caaagaaact cgataaaggt gtttttccag gaacattagg
    11701 gtctatacat cttaatacag ttgcagcaaa agccttttca ctattatatt taagtacaga
    11761 taaatttaaa aagataatgg agcaagttgt agtaaatgct cagactctag cttctgaact
    11821 gatttcacat ggttttagta ttgtaagtgg aggtactgat aatcatatag taatggttga
    11881 cttaagaagt aagaatctta caggaaaaca atttgaaaaa gctcttgaat atgtaggaat
    11941 aacagttaat aaaaatgtta tacctgacga cccacaatca ccatttgtaa ctagtggtgt
    12001 tcgtataggt cttacatcaa tatctcaaag aggtctgaaa gaaaaagaag ttatacagat
    12061 agcagggata atgaataagg tagcagaaaa tattgataat aaagaagtat tagatgaatg
    12121 taaagcagag gcacaagaac ttatatctaa gtttccatta tatccagaag ggtattttga
    12181 agattaaata ttttgatttg tatagctcac aatttataaa gcctgtaaca taaaatttaa
    12241 taatatataa ccactataag gtgttgatta atcaacacct tatttttttt gaaaagtaat
    12301 atacaagcta tcataagcat ataattcctt atagataatt aacaaggggg ataaagttat
    12361 gaggtattat aataaaccta ccaaagaagt attaaaatac ttaaaaacaa atccagaaat
    12421 tggacttgat gataatgagg tagaagaaag gaagcttaga tatggattaa atgaatttac
    12481 tataaaagaa ggtagaacat tttgggacga gttgggagaa agtttgacag aacctatgat
    12541 attaattctc ataggagcag cagtaataag ttcttttgtg ggagaattac atgacgcatt
    12601 aggtatttta ggggctattt ttattggaat ttctataggc ataataactg aaggaaaatc
    12661 taaaaaagca gctcatgccc tgtcaaaatt aacagaaaat atagaagtaa aggtgcttag
    12721 aaatgggaag ataattaaaa tatcaaaaaa tgatttagta ccaggagata ttgtatatat
    12781 agaaactggg gatatgatac cagcagatgg aagacttata cagtctataa atttgaaact
    12841 tagagaagat atgctaacag gagaatctga tgatgtagct aagaatgctg atgctgtatt
    12901 agatatggaa gtagtttatt ctaaaacaga aataatcgaa caggatgcaa tacctgcaaa
    12961 gcaagtcaat atggtatttg gagggactct tgtagcatat ggtaggggca taatggttgt
    13021 cactcatact ggtgataaga cagagatggg taagatagca cagaatttat caaatgaaga
    13081 ccagcaaact ccacttcaaa ttaaattagg gaagttgggt gctaaaatag caggaatatc
    13141 aggcgtaata gctactttat tatgtatgtt tatgattata cagatgcaga gaaaaggtat
    13201 gttaatttta gatacaagca gtgtattatc tttcttacaa tcattagaac ctgctaaaaa
    13261 tgcatatatg gtttgtattg cattaatagt tgcaactgtt ccagaaggtt tgccaactat
    13321 gataaatatt accttagcta taacaatgca aaagatggca aagataaatg cattagtaac
    13381 aaagaaagaa gcctgtgaaa ctataggttc tgtttctgta atatgttccg acaaaacagg
    13441 gactttaaca caaaacaaaa tgatggtaga ggtagcatat gttgatggta aatatataag
    13501 tggaggagag tatcaaagta atagctattt tgaacaaaac tgtatagtaa attcaactgc
    13561 agatatagaa aaagaagata attcatttaa atatatagga agcgcaacag agtgtgcatt
    13621 acttttatat cataatgata agaactataa tgaaatgaga aaacaaacgt atttgatatc
    13681 acaaatacca tttagttcag aagaaaagaa gatgtcaaca ttaattcgtc aagaggattc
    13741 agatatatta ctttcaaaag gtgctccaga agtattatta aaaaaatgtt cttatgtaca
    13801 acaaggaaaa aatattgttc caataactcc aaaagtagaa aaaagtattt tagatgagat
    13861 taagaagtta caaattaaat ctatgagaac attaggattt gcttataaaa aaatgagtaa
    13921 ttctaaaaca gaagttgcag tgacttcaga aggtgaattg aatttaatag gaaattcaag
    13981 aagttatatg aaggaagata atttagtttt tagtggattt gtaggaatag tggacccatt
    14041 gagagaaggg gtcaaagatt ccattgataa agcatttaat gcaggcgtag atgtaaaaat
    14101 gcttacagga gataatataa atacagcaac agctattgga aatgaattag gattattaaa
    14161 tgatgggaaa aaggcagttg aagcaacata tatagatgta ttgacagata aagaattgag
    14221 agaagaaatc aaaggaatat ctattgttgc aagaagtaaa ccagatacaa aaatgagaat
    14281 agtttcagcg cttcaaaaaa gtggcgaagt tgtagctgta acaggtgatg gtataaatga
    14341 tgccccagca cttagtcaag cagatgttgg aattgcaatg ggtatttcag gaacagaagt
    14401 atctaaaaat gcagcagata taatattgac tgatgatagc tttagtacta tagtagaggg
    14461 aataaaatgg ggaagaggta tatatgagaa ctttcaaaga tttatacagt ttcagcttac
    14521 tgtaaatata gtagcattta taattgctat aatatctcaa cttactggta aggatatgcc
    14581 atttactaca atacaattat tatgggtaaa tataataatg gatggtcctc cagccctagc
    14641 attaggatta gaacctgtta gagattatgt attgaaaaga aaaccaataa atagacattc
    14701 tggaataata gctaggtcta tgtttgtaaa tattattata aatgctattc ttataattac
    14761 aattgtattt actcaatcag cttttaatat attgggagct acatcagaag aacaaggtac
    14821 tgttatattt tctttatttg cattcagtgc cctttttaat gcattaaatt gtagagagtt
    14881 tggtttaaat agtacaatac caaatttctt taaaaataaa ctggcattgc aaataatagt
    14941 agttacaggg ataattcaaa taatatttac acaagtgttc cagagtttct ttaattctgt
    15001 ttctttggac tttgatatgt ggataaagat aatactattt gcatccacta tcctattgtc
    15061 aaatgaattt gtaaagctaa ttcttagaac aatgaaaaat agtagaacta tgaactttaa
    15121 tagtaaaaat taattcctat gaaaccgcaa agtactatat attgtaactt tgcggttttt
    15181 gtttgtttaa tgttgtttta tattaccatt ttcatattta attttttatt aatctaaaca
    15241 caatcttcca ttgtaattgc ttcatctgtg tcaacacatt caaagtcaat atctaatttt
    15301 tgtaatattt tgtatgcctc tttttgcaaa ggagtatcaa attcaatagg tgattttgtg
    15361 taaatataac tgataaaaaa catgatttat ttcattcctt tccatttaaa aacttatagt
    15421 tatagtgtat cataaggtta taaaatatag ataaatatag tataaattta aaatatgtac
    15481 agacaaaaca aaaaaatcat attctaagta atacttggga aaaatgatat tatcataata
    15541 aataatcttt gtaaaaactt atatagaatc tattaaacag acactaagcc ataaaaactt
    15601 tactaaatat aaaattcgta tctaaataga tatatagaat aatattttac tgaagtagag
    15661 tgatttttaa gaattttata tataaattat gttatcataa ataaagatat agattataaa
    15721 atttgttaat aaaataaagg gcagggaggt aagtttcatg ttttccaaaa tcttagtcaa
    15781 aacatttatc agagatagcg aaaacgttca aaatacagat gttagaaata agtatggtta
    15841 tgtagctggt gtagtaggta tattatccaa tttactttta tttgtgataa aggtattcat
    15901 aggaatgctc acatctagta tagctataat ggctgatgca tttaataatc tttctgatat
    15961 ggcatcttca gcaataacta tgataggttt taaattagca agtaagccag ctgataaaga
    16021 acaccctttt ggtcatggaa gaatagagta tttatcagca ttaatagtag catttatggt
    16081 gatgttggtt ggacttcaat ttgtaaagtc atctatagaa aggatagtaa atccaattcc
    16141 tgtaaaattt gaagtaatac cacttatact tttaattgca tctataatga ttaaaatctg
    16201 gttgagtcgt tttaataaat ttatgggaaa taaaattgat tcttcagcct taaaagcagt
    16261 ttcacttgat gctttaggag atgtatttac ttcaagttgt gtagttatat catttattgt
    16321 agctagattt actaattttc ccatagatgg atatgttggt atcgtagtat cattagtgat
    16381 actttatgct ggtttctctc ttgtaaaaga tactataaat cctcttttag gggaagcacc
    16441 ggatgaagaa atggtaaatt ctattataga gctattgtta tcttataaat atataatagg
    16501 tacacatgat ttaattattc ataactatgg agttggtaga tgtattgcat ctatacatgc
    16561 agaaattcca tccaacatag atataatgga aatacatgaa attatagata ctgcagagag
    16621 agaaatatct gaaaaattag atatatatct agtaattcac atggacccaa tatgtcttga
    16681 agataaagaa gttatgtcag ccaaaaaaga acttgaagaa atacttaaga aaaatagtct
    16741 tgtaaaatct atgcatgatt ttagaatagt tggaaaagga agcaagaaga atttaatatt
    16801 tgatatagta gttaatcctt ccgaattttc caaaaacatg tcagaagatg acttaaaaga
    16861 agatataaca aaattagtta aggagataaa tcctgaatat aattgtgtaa ttgttgtaga
    16921 taaggatttt atttaattat taattaatct catcataagg taaaaaatgt aaaaaggata
    16981 gacaatagta tagaggcata atataataga agtatataat tgtattttta atataaataa
    17041 agcaatttta attgttttta tgaaatatta tagagatgtt gaagtatatt ctattattgg
    17101 gcaccttatg gatatactga gtcagtggtg caaccggcta tgaatataaa tttatttatt
    17161 ttcatagctt tttttgtata attttttagt aaaaattact ttatatacaa tattaatgga
    17221 agattagatt ataaattata ggtaacctaa aggggtgaga tttacatgaa gaaaggaaat
    17281 agaaaggcat tattaattag tttaattatg attttaagta tggtggtgtc tacaatatat
    17341 ccaactgtat cttatgcttc agaattagga gagaatagtc agattcaaag tggttcaact
    17401 aattcatcaa ctggagagga gaaggaaagc gacaataaaa agccagaaca gactccagag
    17461 aaagataagg caacagataa taaaaaacca gaacagaccc cagaggaaga aaaaccaaca
    17521 gataataaaa aaccagaaca gaccccagaa gaagataagt caacagataa taaaaagcca
    17581 gagcaaactc cagaaggaga aaagccaata gataataaaa agccagagca gatacaagaa
    17641 gaagataagt caacagataa taaaaagtca gaacaagctt tagaagatga aaaaccacta
    17701 gacaataaaa atacagaaaa aactccagag gaagataatc tattagaaga tgaaaattta
    17761 ttgaaagttt tagaagaaga acttaatgaa gaaaatgaag actatggatt tgttgtaaaa
    17821 attaataaca atacaataga aacggagtca atgaaaaaaa tatcatttaa tttaacttat
    17881 actccaacat caaaaggaat acaagcagga gattcaataa cttttaaggt gccagatgta
    17941 ttcaataaag ttaatttaga ttatacaagt gaatgctttg ataaaacaga aagtaatgga
    18001 gagtatacac ttacatttag agaattacct aatggccaaa gtgtaatgca aggtaaaata
    18061 ggtttggaag catatgttaa aaaggttgat gaagatacta atgcaaaaat acatattgaa
    18121 actactggaa aaatagaaag tggaagtgga gatatagatg tagaaataaa acctggagat
    18181 aaaacggatg ttccagatgc taaaggaaca cttaaaaagc ttgttgaagg aaaaaaatca
    18241 actactgtat ttatgccagt taaaaataaa gatataaatt acagtataca agtaaatgaa
    18301 aagcaggaag agttaaaaga cattattttg tatgatgagc ttcctgaagg attgacattg
    18361 ataaatggtt ctgtaagtgt agtaacaagt gatggaaaag aagttagtga ttttaatatt
    18421 gaacagagta aaaattctat ttcagttaat tttggaaata tagataaatc gtatactgtt
    18481 aagtataagg ctagaatcag tgacaaaaat gcaaaacatg gtaataaata taagaatgta
    18541 gctaggattg aatctgatgg taagaagata caagaagatg atgctactgt aagtatattt
    18601 gatagaggag atgattatct tcttactaaa ggacattcag gagcaacaaa tattactcaa
    18661 gttggtcaag taataaacta tcagatttca ataaatgatg ataaatcacc aataagtaat
    18721 gttgttataa cagataatat accagaaggc atgagattaa ctacttcagg agaagctggg
    18781 catgatttta gagttgtaga aattccaatg aatgggagct ggactccttg gagtaaagaa
    18841 aaaattgcca ataatatttc atataaagta gaagaaaaaa gaaatgaaag tgggcaagta
    18901 gataaagtta taactggatt tacaattaat ctcagtaaag aagaagtgga atcaaagttt
    18961 tttatagctt atacattaaa ggtaattagt attgaagata gctatataaa tagagctgtt
    19021 cttgatgcaa ataatagtga aattgataaa aatgatgaga taaactttaa gaaaaattct
    19081 ggattaataa gcgcaaaaaa agaagttgat aaaaaagttt taaacagtag tgataaccag
    19141 attgttaaat acaaaatcaa tatgtcaact tatggagttt atgatgcagg acaagtaaat
    19201 cttttagatg aagtaaactc agttctagaa atatctaata taaaatattc tgataatctt
    19261 gaacttaaaa aagaagctgg agatggaaaa aatacaataa gattagtaaa taaatacgaa
    19321 tttaaacaga taaaagaagg ggaacctgtg caaagttggg ttacatttga tgcaaacttc
    19381 acaaatgtaa aagttgggga gactatacga aatgtggctc agattaatgg ttcaagtcct
    19441 ccaggagtag agactactaa gcaaggttat gcttttgaag ctaaaaaagt ggatgcttta
    19501 gataaaaatg tactttcagg tgctaagttc aatttagaag atgcatttgg aaatatagta
    19561 gttaaggatt tagttagtga tgaagatggt ataattcaat ctagtgtaaa aaacccagga
    19621 acatattatt tagtggagat aatggctcca cgtggatatg aaaaactgaa ggataaagtt
    19681 aaggttgaaa ttggtaatga agatattggt aagatagtag atattgggaa tatagaaaat
    19741 ctaaaacaag aaaatccacc agtaaatcca ccaatacctc cagatacaga tgaaccaata
    19801 gtaaatccac cagtaccacc aagcacagat aaaccaagga aaccatcaag ttcatctgat
    19861 acagagaata ctatagttat aaatccacca gtaccaccat cagaagatat aataaatccg
    19921 ccaataccag aggtattgaa tccgccagta ccaccatcag aagagatgat agaaactcct
    19981 gttaaacaga ttattccaat accagaagta gtaaagccat cagtgtcaga agaaaaaaat
    20041 aataaagtta aagatgatac tttggtaaat ccaccagtac caccaaaaac aggggatagt
    20101 actacaatta ttggagaaat acttttggtt ataggagcta ttgtaggact tatcgtatta
    20161 agaagaaata aaaatacaaa ttagacccta acattataaa aatataagtt atattaaaaa
    20221 atatcttcta aaacaatatt taataatgaa aatattgtta gaagatattt ttttttgaag
    20281 atttatgtaa aaaaataata actttttaga aaaaagttcc aaagggatat agacaattaa
    20341 aaagatataa gctataatat aaatataaaa ttaaatgagg caaaactagg gaaacctagt
    20401 cacgcaaagc tataggggct aaagtttagt aaaccatgcc agccagttgc cgaaaagagt
    20461 aaaaatttct ttttgtatat acaaagatac tcttgggtat cttttttatt ttgaaattta
    20521 ttactcccgg cctaactcaa aggagggaat aatatgagac caagtaaaaa attattaata
    20581 gctataatat caatattctt aataagttca gttccagtaa gtgcacatgc agatagtact
    20641 actatacaac aaaataaaga cacacttagt caaatagtag tttttccaac tggaaattac
    20701 gataaaaacg aagctaatgc tatggtaaat agattagcta atatagatgg aaagtattta
    20761 aatgcattaa aacaaaataa cttaaaaata aaattattaa gtggaaagtt aacagatgaa
    20821 aaagaatatg cttatttaaa aggtgtagtt cctaagggat gggaaggtac tggaaaaact
    20881 tgggatgatg ttccaggttt aggtggaagt acagtagctc ttagaatagg atttagtaac
    20941 aaaggtaaag ggcatgattc aataaattta gaattacatg aaacagcaca tgcaatagac
    21001 catatagtat taaatgatat atctaaatca gcacaattca aacaaatatt tgctaaagaa
    21061 ggtcgttctt taggtaatgt aaactactta ggtgtatatc cagaagaatt ttttgcagaa
    21121 tcatttgcat attactattt aaatcaagat acaaatagta agttaaaatc agcttgtcca
    21181 caaacttata gctttttgca aaatttagct aaatagagtt ttaataaatt taaaataaat
    21241 ataaataaag agatgctatt ataatagcat ctcttttata ttgcgtttaa atctaataaa
    21301 ttttgtctta tgtataacta tgatagatta tcaattacta ctccttatac aaggcttcaa
    21361 cgtgtttatt atgcatttga gtaattatcg taggtataat agaaattatt gaaccaatta
    21421 ctatcaataa aattcctata accatgttta tagggataat ttctttaagt attaataatg
    21481 ctagtattgg agatattact ggtttaaaga agaatactaa agatgtaaga ctagtagatg
    21541 tagcttccat tgccataaag taaagcgcat aaccaacacc tgtaacaaat acgaatacat
    21601 aaatcataat gggcatattg tgtaaggtat atccactaaa aatagggata tttgcaaata
    21661 catgaagctt atttttattt aatatatctg cgataaaatt aattttagtg agtaaaacca
    21721 atatcaacat ttccaaacta ccaaatataa agctaaagca ggttacaact attccaccaa
    21781 attttaaggt ttttctttta ccaaatacag tatacattga aaaaataata gcagaagata
    21841 atgttaagaa tattccacta agagttagtt ttgtatgcaa tggatttatt ataactataa
    21901 ttccaagaac ttctaatata agtgaaatta cattgtgcct atatattttt tccttcaaaa
    21961 ttaagtaagc taaaagcatt acaaagactg gattacaact gaacaaaaca gcaactacag
    22021 atgcctttgt gtttagaaca gcaagttgat acaatgacat acttactact acacacataa
    22081 aacctaaaaa tgcaaagtat tttaagtctg attttgtaat agaaagacta agagctctta
    22141 atctttttac agcaaaaggt agtaagacta aaccgccaac aaaaaatctt gataaagtta
    22201 tttgtaaggg attaaagtca ttagtgacag tttttagact aatttccatt gaactaaaaa
    22261 ataaggtagt cagtattata taaacataac cttttttcaa gtcaaacacc tccttgtaat
    22321 ttatattagt actatagata agaatattca agcatattgg aataatatgg tatgtataaa
    22381 ata
//
LOCUS       DAEQCW010000061        22143 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.061, whole genome shotgun sequence.
ACCESSION   DAEQCW010000061 DAEQCW010000000
VERSION     DAEQCW010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22143)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22143)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22143
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.061"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            444..1514
                     /locus_tag="KRO40_002284"
     CDS             444..1514
                     /locus_tag="KRO40_002284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093101.1"
                     /translation="MADIRLENVTKSYNKKNTVIENLNLTIEDGSFTVLVGPSGCGKS
                     TTLRMIAGLEDITSGRLKIEENDVTKTDASKRDIAMVFQNYALYPHMTVRENIEFGLK
                     NKKVEKEKREKLITEVIDVVGLREYLNVKPGNLSGGQRQRVALARAMVKNPKVFLMDE
                     PLSNLDAKLRNQMRTELIQLHQKLKSTFVYVTHDQVEAMSMADKIVIMNKGKIMQIGS
                     PKKIYQNPKNLFVAQFIGSPCMNILDIKNDIKFGFRPEKATLESINIDGKNDDVFSLF
                     GKVVTKEVLGNETIYCLSVLNREIRVKTENDIFDIGRTLRISVLEKDLYYFDKNGERI
                     EDVKVCKSMYSKIKGDIYEKAI"
     gene            1498..2367
                     /locus_tag="KRO40_002285"
     CDS             1498..2367
                     /locus_tag="KRO40_002285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBH2093102.1"
                     /translation="MKKQFNKAYLYITPAIIGTLLFIVYPIIKTISLSFKSGSLLSST
                     FENVGLNNYTELLKNPEFIQTITNTAIYTFFMVTISISLAIVLAVWLNKNSIIHNLTQ
                     SIIFTPHVISLVSVAVLWLWIMEPQYGFLNWILSTLHLPTSKWLSSESSALMSLILIG
                     IWKTLGYNILIVLSGLKSIPNYIYEASKLDNANKITNFFKVTLPLLSPTIFFLMITTT
                     TASFQVFDEISIMTQGGPVGSTNMLSYYIYESGFIYYDIGQASAASMFLLAIVMIATY
                     ANFRLLSKKVHYQ"
     gene            2411..3271
                     /locus_tag="KRO40_002286"
     CDS             2411..3271
                     /locus_tag="KRO40_002286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBH2093103.1"
                     /translation="MDIIQPIKKDKVDIKKIASKSIEILILLLLSAIFIFPFIWMLST
                     SFKNPQEMMQLPPTIIPNDIVLENYSTAWHSGPFFRYLLNSVFVTGSVLIVQFLVMVP
                     AAYAFSKIKFKGEKMLFGLLLVGLMIPPQVTFLPVYMMMSKFGFINTYVPLIIPFMTS
                     SFGIFLLRQNFMQISDEIIEAAKLDNASDLKIMFRIMVPMAKPAVITFILFNFIYHWN
                     NYFWPLVMTNTDAIRTLPIGVALLKSSEGITAWNVIMAGNIILILPIILVYIFANKKV
                     KEAFMYSGIK"
     gene            3302..4606
                     /locus_tag="KRO40_002287"
     CDS             3302..4606
                     /locus_tag="KRO40_002287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2093104.1"
                     /translation="MKLKRKLATGLAITLLLGSLVGCSNSNDANASKGEKTDSNITKI
                     DFWAPLGGTNGETAQKMVDQFNSEHKDVQVNMLKQKDYYENATKLQAALTSKDQPDVT
                     LLEITQTGTFASAGALVDMSKYFDKTYQERFFSGLLTNSYYEDKFVGMPFNRSTPILY
                     INKDMATKAGLDPSGPKSWEELKDYASKMTNKSEDTYGFETPIDIWFYEAMVMQSGGE
                     ITNGKKVAFNNEAGQAPVKFWQDMMKAGIMKMPPGEDYNAWDVAKQDFVNGKVGMIFT
                     STADLAGLMQQTEGKFEISTAFLPKNQKYATPTGGANLVMLEGGTDKEKEASAEFIEW
                     MTQTDKIVQFSSSTGYLPTTEDATNSEKLQTLYKEKPQYKVATDQLQYAVALPMLNGY
                     KEATDKLMDEIKKGLTDLNANPKDVVSKGTSAMQAVIDKTNK"
     gene            4669..5931
                     /locus_tag="KRO40_002288"
     CDS             4669..5931
                     /locus_tag="KRO40_002288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline phosphatase family protein"
                     /protein_id="HBH2093105.1"
                     /translation="MTKVIVLSVDSLFEKDLEFVKNLPNFKSILENCSIVKNINCVYP
                     TLTYPCHTSMVTGVYPKKHGIYHNEKFDPNKENKDWYWYSKDIKAKTIIDVAKENNLT
                     TSSVLWPVMGANPNIDYNIAEIWAPSREDDPRETFERSSSKVIMDGIYNRHCHYIDWK
                     LEPNMDLFGVNCSVDIIKEYKPDLMLIHLATLDHTRHNYGLFNDEVDKALKMNDKWLG
                     DIIQATKDAGTYKDTNFIILGDHGHLRVDKVINPNVLLKSNGFIKVENGEVKDFDAYV
                     NSSGISAQIIVNNLDRLTELRELLEEFKEELFIENIFTKEEASNLGLEGDFEIVIEGL
                     EGISFGNDFEGSIIKDSDIKDYKFAVATHGHLPTKGNRPPFIAFGPNIKGGVVIEEGD
                     LRAHAATILKMFNLKLDGVEKEAFDFIM"
     gene            6118..8088
                     /gene="uvrB"
                     /locus_tag="KRO40_002289"
     CDS             6118..8088
                     /gene="uvrB"
                     /locus_tag="KRO40_002289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="HBH2093106.1"
                     /translation="MDFKIKSDFKPTGDQPEAIKSIVDSINRNEKFSTLLGVTGSGKT
                     FTMANIIQQVKKPTLIMAHNKTLAAQLYSEFKEFFPDNAVEYFVSYYDYYQPEAYVAH
                     SDTYIEKDASINDEIDKLRHSATASILERRDTIIISSVSCIYGLGDPKDYKELMLSIR
                     PGMQRDRDDVIKRLIEIQYERNDINFTRGTFRVRGDILEIFPASNDEKAIRIEFFGDE
                     VDRITEIDYVTGKIVGTRNHVVIFPASHYVTTPERIEKAIVEIENELQEQIKFFKEND
                     RLLEAQRIEQRTKYDIEMLKEIGFCQGIENYSRHITGRSEGERPYTLMDFFPDDYLII
                     IDEAHVTIPQVRGMYAGDRSRKTSLIENGFRLPSALDNRPLNFQEFEGNINQMLFVSA
                     TPGPYEIQHSETIAEQIIRPTGLLDPIVEVRPINNQIDDLVGEITKTIEKNERVLITT
                     LTKKMSEDLTNYLKEIGIKVKYLHSDIVTLERTEIIRDLRLGKFDVLVGINLLREGLD
                     IPEVSLIAILDADKEGFLRSETALIQTIGRAARNENGRVIMYADRITDSMQNAIDETK
                     RRRDIQNLYNEEHNIIPKTIQKNIRDSIEATKVAEEEVVYGISDTDDKDEIRANIDKL
                     KSEMMEAAQNLQFERAAELRDKVKQLEEKLEK"
     gene            8107..10932
                     /gene="uvrA"
                     /locus_tag="KRO40_002290"
     CDS             8107..10932
                     /gene="uvrA"
                     /locus_tag="KRO40_002290"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH2093107.1"
                     /translation="MEDKIIIRGAKEHNLKNIDLELPRDKFIVFTGLSGSGKSSLAFD
                     TIYAEGQRRYVESLSAYARQFLGQMEKPNVEYIEGLSPAISIDQKTTSKNPRSTVGTV
                     TEIYDYLRLLFARVGDVYCPTCGEKISQMTIQEIVDKMLDFPDRTKLQILSPIVRGQK
                     GTHKKVFDNIKKEGFVRVRVNGENYEVSDDIILNKNQKHNIEVVVDRIVIKDGIESRL
                     ADSIETAVKLSDGLVIAQIIDGEEILFSTKFACPEHGIGIEELSPRMFSFNAPFGACD
                     VCNGLGESKEVDPELVVPNKDLSIKQGAVAAWGSTGVNDDTYYSKMIKSLAEHFNVSL
                     TTPFKDLPDDFVEELLYGKDNIIVEFTYESKFGGTRNYKSYFEGVIVNLERRYRETNS
                     DYMRDKIEEYMAERPCPKCKGMRLKKEVLSVLVDGKNIMEVTNLSVNELIDFMENINL
                     TEKQRFIAHEIIKEIKGRAMFLRDVGLDYLNLSRKAGTLSGGEAQRIRLATQIGSALV
                     GVLYVLDEPSIGLHQRDNDRLITTLRHLTDLGNTLIVVEHDEDTMREADYVIDIGPGA
                     GIHGGEIVAQGTLDEIIENENSITGQYLSGKKQILLPETTREGNGSFIEIVKASENNL
                     KNIDVKFPLGKFTCITGVSGSGKSTLINDILYKGVASKVNRLKQRAGKHKEIKGIESI
                     DKVINIDQSPIGRTPRSNPATYTGVFDFIRDIFASTNEAKARGYKKGRFSFNVKGGRC
                     EACKGDGIIKIEMHFLPDVYVPCEICKGERYNRETLQVKYKDKTISDILDMNVEEAVE
                     FFENIPNIKRKLETLMDVGLSYIKLGQPSTQLSGGEAQRIKLAAELSKRPTGKTLYIL
                     DEPTTGLHMADVDKLIQVLQRLADTGNTIIVIEHNLDVIKTCDYVIDLGPEGGDKGGT
                     IVATGTPKEVSKVDGSYTGQFLKKYFS"
     gene            11191..13008
                     /gene="uvrC"
                     /locus_tag="KRO40_002291"
     CDS             11191..13008
                     /gene="uvrC"
                     /locus_tag="KRO40_002291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HBH2093108.1"
                     /translation="MFDIQEHLKKLPSEPGVYLMKDKYDHIIYVGKAISLKNRVRQYF
                     QSSKNHTSKVKSMVKNIYKFEYIITDSELEALILECNLIKRYRPKYNVVLRDDKTYPY
                     IKVTTNEDYPRILKVRRVLKDKAKYFGPYTNITAVNDTLELISSTYPIRSCKIDIDKA
                     IKNKTRPCLNLHINKCLGPCTGNVSKEEYGKMIEEIIMCLSGKEEKLMELLKEKMNES
                     SMNFRFEEAAVYRDKIKSLEEMIQKQKIDATVSDLNQDVVAMARAHNEACVQVFFIRN
                     GKIVGREHFILEGVMDSPRASILSSFVKQFYNEQEYIPKELIIEDEIEDSSILEEWLS
                     SKKGQKVTIRVPQKGEKKSLVEMVRKNAVEYLEKFSDMNKRKYEKSIGALEELKQILN
                     LEKLPIRIEAYDISNIQGVDSIGSMVVYTNAKKDKKEYRRYKIKTVIGPNDYDSMAEI
                     VDRRLKHGNLPDLILLDGGKGQVSAVKKVLELNDVDIPLWGMYKDDKHRTKGLICKEK
                     EIELDKTTNLYRFIASIQEEVHNYAITYHRSLRNKALTKSILDDIQGIGEKRKKSLLN
                     HFKDVDAIKKATMEELLEVDGMNKSIADNVYNFFRKEEN"
     gene            13008..13937
                     /locus_tag="KRO40_002292"
     CDS             13008..13937
                     /locus_tag="KRO40_002292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HBH2093109.1"
                     /translation="METSNKVSIREIIKELKLKVVYMPDDVDYYVYSQDINRPGLQFA
                     GYFDYFAYERIQIVGKTEYNFFGLMDSHIREEVLDRFFSYEIPALIISRDLEIKPDVI
                     EKAKKYKRILLSTNRNTTRLINRLSNYLDNKLAPHTTIHGVLVDIYGIGVLIKGESSI
                     GKSETALELIQRGNRLVADDAVEIRKLDESMLVGQSPELIRHFLEIRGIGIIDVRSLY
                     GVGAIKNSKMIDLVVHLEAWDETKYYDRLGLDKEYEEILGVNVEKLVVPVKPGRNTAM
                     ILEVAAMNFRQRGMGYDAAQEFTKKLSKLIDTK"
     gene            14151..15947
                     /locus_tag="KRO40_002293"
     CDS             14151..15947
                     /locus_tag="KRO40_002293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannonate oxidoreductase"
                     /protein_id="HBH2093110.1"
                     /translation="MGIEYFSKLLESSTEKELLLSKKSNNISTARLISFLIVIAGLAI
                     GFYNKNIVGIFVGVLSIIIFIALLVIHSKVKEEETYFKSKSEVLNKYIKRFGDGWKEF
                     KIDGKEYLKDENLQAKDLDLFGRASLYQYICVANTSYGKNFLAKYLWNENPDENVILE
                     RQRAIKELLSKDDFSIHIQTLSNIIGKEQKNNSDSSIESFIEYGENKNVYIPKWMHIF
                     TWGLPTATILSFIFCMLGFLPVLPVFLLFIIQLGFSGFGYPRLMQTLAPLFSFSRSIQ
                     VYEKMFEVLEKETFESAYLKELQDKLSKGSGVSRGVKQLNSIGNAVNLRYNQILYIIA
                     CGVLMWNYHCAEALERWKGIYGNQIRDWFESIGEFEALISLTVISHVKENTCFPVIKY
                     EDTPRLKVEEVYHPLIAEKSVIANSIQLNSQTCIITGSNMSGKTTFLRSIGVNLVLAY
                     AGAPVCAKSFDATCMAIFTSMRIQDDVSQGISTFYAEILRIKSMIQYSLKELPMLVLV
                     DEIFKGTNSADRIIGASEAVKKLSKPWVISMVTTHDFELCDLSGSGDVEVVNYHFSEY
                     YVDDKIHFDYKIKDGRCKTTNAKQLMRMAGIL"
     gene            complement(16087..17868)
                     /locus_tag="KRO40_002294"
     CDS             complement(16087..17868)
                     /locus_tag="KRO40_002294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBH2093111.1"
                     /translation="MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEID
                     KLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTNSAKALNARRTIVELLLSDHPQD
                     CFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETV
                     CNDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKL
                     WDVLNKKEKTIVVQVAPAVRVAIGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGA
                     DFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLNLASSCKSPQGMFGS
                     IAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKM
                     IKEAAIDLPNLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNF
                     TNVRGLKGIREASIDVDGTTVNVCIVNTLKNARKIMDKVRSGECKYHIIEVMACPGGC
                     VGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEPNSDVAH
                     KYLHTHYFDKSCVYGECPQECACEEAK"
     gene            complement(17891..19777)
                     /locus_tag="KRO40_002295"
     CDS             complement(17891..19777)
                     /locus_tag="KRO40_002295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-quinone oxidoreductase subunit NuoF"
                     /protein_id="HBH2093112.1"
                     /translation="MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTG
                     CTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGFCAQGPIVKVYPDNVFYVKVEPS
                     DAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
                     EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPT
                     DKKFVVCNADEGDPGAFMDRSVLEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSI
                     ERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGTALMHSIEGRRGEPR
                     MKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKV
                     ENVGLVEVPMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSL
                     SSIGSMMGSGGMLVLDESDCMVDIAKFFLEFTVEESCGKCTPCRIGTTRLLEILTKIT
                     EGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVDKKCPAG
                     KCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNA
                     IIKK"
     gene            complement(19794..20291)
                     /locus_tag="KRO40_002296"
     CDS             complement(19794..20291)
                     /locus_tag="KRO40_002296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase subunit E"
                     /protein_id="HBH2093113.1"
                     /translation="MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLP
                     KEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKYKISVCLGTVCFVKGADKILSAF
                     EKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
                     LELNC"
     gene            complement(20609..22090)
                     /gene="cls"
                     /locus_tag="KRO40_002297"
     CDS             complement(20609..22090)
                     /gene="cls"
                     /locus_tag="KRO40_002297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBH2093114.1"
                     /translation="MFDISFFEMSIYEIAVTTIYIINFMVILNLIFREKRNINTTLTW
                     LLILVLIPALGFILYIAFGRNISKNNMFRLKEKDDKIIKSNILDTQVKLQSTSEIDSD
                     IHQHKDMIYALANSNNAHYTNNNDVWIYAESSQFFNSLLEELKKAKKYINIQFYIFKD
                     DKIGTEIIDILIDKAKEGVEVRLLFDAVGGRTLKNSTLSRLKESGVKVGSFFPSFLKI
                     VNFNLNYRNHRKIVVIDGKVGFVGGYNVGDEYLGRNPKFGLWRDTHTKLTGDCVIDLN
                     MRFILDWRYTTKEDLDLEKYFIEEDTNSNHPSENIGIQIVSSGPDISELDEIKYGYLK
                     MIQKARKYIYIQSPYLILDSTFIDTLKIACLSGVDVRVMIPSKPDHPFVYWASYSYAG
                     ELLKFGAKIYTYGQNAFLHAKTIVIDDSICSIGTANMDIRSFELNFEVNAFMYSSKKA
                     LEQRIIFENDILNSKEITLDIYNSRSTYIKIKESISRLLSAVL"
BASE COUNT         8523 a         2963 c         3696 g         6961 t
ORIGIN      
        1 ggtaaattta taaaaattaa aaaagtttta ttttttatgt ttaaaccttg taaatttggg
       61 acataatata attgtaaaac ttaatatagc aaaaataaat tactcaatct cccccactta
      121 aagacctcta tcccccatag aggtcttttt tattttcaaa ccaaattata taaaaaataa
      181 atagttttat atgactcttc ataaattaaa atcacattgt gatagcaaac catgaatatg
      241 aaaaatatag aaaattatag ctaacataag ctgtatatca tcttaacttc agtatattta
      301 acaaaaaatg tttataattt aacctttatt ttaataagtt tactatatat tcactttgtc
      361 ttaatatatc ctttacaaat taagagtatt attaatctat aagtaaatcg tagaattaaa
      421 ttaaatattt tgggaggata aaaatggcag atataagact agaaaatgta acaaaatctt
      481 ataataaaaa aaatacagtt atagaaaatt taaatcttac tatagaagat ggttctttta
      541 cagtattggt aggcccaagt ggatgtggta aatctactac gttaagaatg attgcaggtc
      601 ttgaagatat aacttcaggt aggttgaaga ttgaagaaaa tgatgttaca aaaacggatg
      661 ctagtaaaag ggatatagct atggtatttc aaaattatgc attatatcca catatgactg
      721 ttagagaaaa catagaattt ggtcttaaaa acaaaaaagt agaaaaagaa aaaagagaaa
      781 aacttataac agaagttatt gatgtagtag gattgagaga atatttaaat gtgaaaccag
      841 gcaacttatc tggaggtcaa agacaaagag tggcacttgc tagagctatg gttaaaaatc
      901 caaaggtatt tttaatggat gaaccattgt caaatttaga tgctaaatta agaaatcaaa
      961 tgagaacaga attaatacaa ttacatcaaa aactaaagtc tacatttgtt tatgtaactc
     1021 atgaccaggt tgaggcaatg tcgatggcag ataagatagt tataatgaac aaaggaaaga
     1081 taatgcaaat aggttctcca aagaagatat atcaaaatcc taaaaattta tttgtagctc
     1141 aatttatagg gagtccttgt atgaacatac tagatataaa aaatgatatt aaatttggat
     1201 tcagaccaga aaaagcaaca ctagagagta taaacataga tgggaaaaat gatgatgtat
     1261 ttagtctatt tggaaaagtt gtaactaaag aagtgttggg aaatgaaact atatattgtt
     1321 tatctgttct taatagagag ataagagtca aaacggaaaa tgatatattt gatattggaa
     1381 gaactttaag aataagtgta ttagaaaaag atttatatta ttttgataaa aatggagaaa
     1441 gaatagaaga tgtaaaagta tgtaaaagta tgtattctaa aattaaagga gatatttatg
     1501 aaaaagcaat ttaataaagc atatttatat ataacacctg ctattatagg aactttattg
     1561 tttatagtct atccaataat taagacgata tctctaagct tcaaatctgg tagtcttctt
     1621 agttcaacct ttgaaaatgt aggcttaaac aattatacag aacttttaaa gaatccagag
     1681 tttatacaaa ctataacgaa cactgcaatt tatacttttt ttatggtgac tatatctata
     1741 tcactagcca tagtacttgc tgtttggcta aataaaaatt ctataataca caatttaacg
     1801 caaagtataa tctttacacc acatgtaatt tcactagtat ctgtagctgt attgtggctt
     1861 tggattatgg agccacaata tggcttttta aactggatac tatcgacatt acatttacca
     1921 acatcaaagt ggctttcaag tgaaagttca gctttaatgt cactaattct aataggaata
     1981 tggaagactc ttggatataa tatcttaata gtgttatcag gtcttaaatc cataccaaac
     2041 tatatatatg aagcatctaa attagataat gcaaacaaaa taacgaattt ctttaaagtg
     2101 acattgccac tattatcacc aacaatattt tttcttatga taacaacaac aactgcatct
     2161 tttcaagtat ttgatgagat aagtataatg acacaaggtg ggccagtggg ttcaactaac
     2221 atgttatctt attatatata tgagtctgga tttatatact atgacatagg acaagcgagt
     2281 gcagcgagta tgtttttgtt agctatagtt atgattgcta catatgctaa ctttagactc
     2341 ttatcaaaga aagttcatta tcaataaaga aaaagtagat attataaggt ttatccaaaa
     2401 ggaggagaca atggatatta tacaacctat caaaaaagac aaagttgata taaaaaaaat
     2461 agcatcaaaa tcaatagaaa tattaattct attactttta tctgcaatat ttatattccc
     2521 ttttatatgg atgctatcta catcctttaa aaatccacaa gaaatgatgc aattaccgcc
     2581 cactattata ccaaatgata tagtgttaga aaattatagt acagcatggc attcaggtcc
     2641 attttttaga tatttgctaa acagtgtatt tgtaacagga agtgttttaa ttgtacaatt
     2701 tttagttatg gttccagcag catatgcatt ttctaagatt aaatttaaag gtgaaaaaat
     2761 gctatttggg cttttgcttg taggacttat gattccacca caagtaactt ttctaccagt
     2821 ctatatgatg atgagtaagt ttggatttat aaatacttat gttccactta taattccatt
     2881 tatgacatct tcatttggga tatttctgct tagacagaat tttatgcaga tttcagatga
     2941 aattattgaa gcagctaaac tagataatgc ttctgactta aaaataatgt ttagaataat
     3001 ggttcctatg gcaaaaccag cagtaataac atttatatta tttaatttta tataccattg
     3061 gaataattat ttctggccct tagtaatgac aaatacagat gcaataagaa ctttaccaat
     3121 aggagttgcg ctccttaaat cttcagaagg aattactgca tggaatgtaa taatggcagg
     3181 aaatataatt ctaattttac caataattct tgtttatata tttgcgaata aaaaagtaaa
     3241 agaagctttt atgtattcag gaataaaata aaaaattaaa gactaaattt ggaggatgaa
     3301 aatgaagctt aaaagaaaat tagcaacagg attagcaata acattattat taggttcttt
     3361 agttgggtgt tcaaattcta atgatgcaaa tgcatctaaa ggagaaaaga ctgatagcaa
     3421 tattacgaag atagatttct gggctccttt aggtggaact aatggagaaa ctgctcaaaa
     3481 aatggttgac caatttaata gtgaacataa ggatgtacaa gtaaatatgt taaaacagaa
     3541 agattactat gaaaatgcaa caaaactaca ggcagcctta acatctaaag accaaccaga
     3601 tgtaacatta ttagaaataa ctcaaacagg tacattcgca tcagcaggtg ctttagtaga
     3661 tatgagtaaa tattttgata aaacatatca agaaagattc ttttctggtc ttttaacaaa
     3721 ttcatattat gaggataagt ttgttggtat gccatttaat agaagtacac caatattata
     3781 cataaataaa gatatggcaa ctaaagcagg tcttgaccct tcaggtccaa aatcatggga
     3841 agagcttaag gattatgcta gtaaaatgac aaataaatca gaagatactt atggttttga
     3901 aacgccaata gatatttggt tctatgaagc tatggtaatg caaagtggag gagaaataac
     3961 taatggtaaa aaagtagcat ttaataatga ggcaggacaa gcaccagtta agttttggca
     4021 agatatgatg aaagctggaa taatgaaaat gcctcctgga gaagattata atgcctggga
     4081 cgtagcaaaa caagattttg taaatggtaa agtaggtatg atatttacat caacagcaga
     4141 tttagcagga cttatgcaac aaacagaagg taagtttgaa atatcaacag cattcttacc
     4201 aaaaaatcaa aaatacgcaa ctcctacagg tggagctaat ctagttatgc ttgaaggtgg
     4261 aacagataaa gaaaaagaag caagtgcaga atttatagaa tggatgacac aaacagataa
     4321 aatcgttcag tttagttcat caacaggata cttaccaaca actgaagatg caacaaactc
     4381 agaaaagtta caaacattat ataaagaaaa acctcaatat aaggttgcaa ctgaccaatt
     4441 acaatatgct gttgcacttc caatgttaaa tggatacaag gaagcaactg ataagctaat
     4501 ggatgagatt aaaaaggggc ttactgattt aaatgcaaat ccaaaagatg tagtaagcaa
     4561 aggaacttct gcaatgcaag cagtaataga taaaacaaat aaataattat atagacttgt
     4621 aagttgatta aaagtattca ataatatata aatgaagagg taatgtaaat gacaaaggtt
     4681 atagtattat cagtagattc tttatttgaa aaagacttgg aatttgtaaa aaatctacca
     4741 aactttaaat ctatactaga aaattgctcc atagtaaaaa atataaattg tgtttatccc
     4801 actctgacat atccgtgtca tactagtatg gttacaggag tatatcctaa aaaacatggt
     4861 atatatcata atgaaaaatt tgacccaaat aaagaaaata aagactggta ctggtactca
     4921 aaggacataa aagcaaaaac tattatagat gtagcaaaag aaaataatct aactacctct
     4981 agtgtattat ggcctgtaat gggagcaaat ccaaatatag attataatat tgcagaaata
     5041 tgggctccta gtagagaaga tgacccaaga gaaacttttg aacgaagttc cagtaaggtt
     5101 ataatggacg gtatttacaa tagacattgt cattatatcg attggaaatt agaacccaac
     5161 atggatttat ttggagtaaa ctgttcagta gatataataa aggaatataa accagattta
     5221 atgctaatac atttagctac attggaccat acacgacata attatggatt atttaatgac
     5281 gaagtagata aagcattaaa aatgaatgat aaatggctag gagatattat tcaggctaca
     5341 aaggatgcag gtacatacaa agatacaaat tttataatac ttggggacca tggtcatctt
     5401 agagttgata aagttataaa tccaaatgtc ttgcttaaat caaatggatt tataaaagtt
     5461 gaaaatggag aagttaagga ttttgatgcc tatgtaaatt cttctggaat atcagctcaa
     5521 ataatagtaa ataacttaga taggttaaca gaattaagag aactgcttga agaatttaaa
     5581 gaagaattat tcatagagaa tatttttacc aaagaggaag catctaacct tggtcttgaa
     5641 ggtgattttg aaatagtgat tgaaggtctt gaaggaattt catttggaaa tgatttcgaa
     5701 ggaagtatta taaaagattc agatataaaa gattacaagt ttgctgttgc gacacatggt
     5761 catttaccta ctaaaggtaa tagacctcca tttatagctt ttggaccaaa tattaaaggt
     5821 ggtgtggtta tagaagaagg agacctgaga gcacatgcag caactatatt aaaaatgttt
     5881 aatttaaaat tagatggagt tgaaaaagaa gcatttgatt ttattatgta agttgaataa
     5941 agtatttatt ttccatgaat tatagacttc tattgcaaag atagaagtct ttttttatgt
     6001 tttagattta agtaaaattt aaatgggtaa aatatttaaa ataacttaaa caattttata
     6061 aaggtatgat ataataatac atgtcaggaa ctaatgttcg aaaaaaggag tgatactatg
     6121 gattttaaaa taaaatcaga cttcaaacct acaggtgacc aaccagaagc tattaaatca
     6181 atagtggatt ctataaatag aaatgagaaa ttttcgacat tattaggtgt aacgggttca
     6241 ggaaaaacat tcacaatggc aaatatcatt caacaagtta agaaacctac cctaataatg
     6301 gctcataata aaactctagc agcacaactt tacagtgagt ttaaagaatt tttcccagac
     6361 aatgcagttg aatactttgt aagttactat gattattatc aaccagaagc atatgtagct
     6421 cacagtgaca cttatataga aaaagatgca agcataaatg atgaaataga taaacttcga
     6481 cattctgcta cagcatctat tttagagaga agagatacta taataatatc atctgtatct
     6541 tgtatatatg gacttggtga cccaaaagac tataaagaac ttatgttatc tataagacca
     6601 ggtatgcaaa gagacagaga tgatgtaata aaaaggttaa tagagataca atacgaaaga
     6661 aatgacataa actttacacg aggtaccttt agagttagag gagatatact agaaatattc
     6721 ccagctagta atgatgaaaa agcaataaga atagaatttt ttggtgatga ggtagataga
     6781 ataacagaaa ttgattatgt aacagggaag attgttggta ctagaaatca tgttgttata
     6841 ttcccagcat ctcactatgt aacaacgcca gaaagaattg aaaaggcaat tgtagaaata
     6901 gaaaacgagc ttcaagaaca aattaaattt ttcaaggaaa atgataggct attagaagca
     6961 caaagaattg aacaaagaac taagtatgat atagaaatgt taaaggaaat aggattttgt
     7021 caggggatag agaactattc tagacatatt acaggaaggt cagaaggaga aagaccatat
     7081 actttaatgg atttcttccc agatgattat ttgataatta tagatgaggc acatgtcact
     7141 ataccacaag taagaggtat gtatgcagga gacaggtcta gaaaaacatc acttatagag
     7201 aatggtttta gattaccttc tgcacttgac aatagaccat taaattttca agaatttgaa
     7261 ggaaatataa atcaaatgtt gtttgtaagt gctacaccag gaccttatga aattcaacac
     7321 tcagagacaa tagcagaaca gataataaga ccaactggcc ttttagaccc aattgtagaa
     7381 gtaagaccta taaataatca aatagatgat ttggtaggag aaataactaa aactatagaa
     7441 aaaaatgaaa gagtgcttat aaccacttta actaaaaaaa tgagtgagga cttgactaac
     7501 tatcttaaag aaatagggat aaaagttaaa tatttacact cagatatagt tacattagaa
     7561 agaacagaaa taataagaga tttaagatta gggaagtttg atgtccttgt aggaataaac
     7621 ttacttagag aaggattgga tataccagaa gtttcactta tagcaatttt agatgcagac
     7681 aaagaaggtt tcttacgttc cgaaacagct ttaatacaga ctattggacg tgcagctaga
     7741 aatgaaaatg gaagagtaat tatgtatgca gacaggataa ctgactcaat gcaaaatgct
     7801 attgatgaaa caaagagaag aagagatata caaaatttat ataatgaaga gcacaatatc
     7861 attcctaaaa ctatacagaa aaatataaga gatagtatag aagctactaa ggttgcagag
     7921 gaagaagttg tatatggaat atctgataca gatgataaag acgaaataag agctaatata
     7981 gataaattaa aatcagagat gatggaagct gctcaaaact tacaatttga aagagcagca
     8041 gaacttagag ataaagtgaa acaattagaa gaaaaattgg aaaaatagaa aggtaaaaac
     8101 aacattatgg aagataaaat tataataaga ggagcaaaag aacataattt aaaaaatata
     8161 gatttagaat taccaagaga taaatttatt gtttttacag gtttgtcagg gtctgggaag
     8221 tcttctttgg catttgatac aatatatgca gaaggacaga gaagatatgt agaaagtcta
     8281 tctgcttatg caagacaatt tttaggtcag atggaaaagc caaatgtaga atatatagag
     8341 ggtttatcac cagctatctc aattgaccag aagactacct caaaaaaccc acgttctacg
     8401 gttggaacag taacagaaat atatgattat ttgagactat tatttgcaag agtaggagat
     8461 gtgtattgcc ctacatgtgg tgaaaaaata agtcagatga ctattcaaga aatagttgat
     8521 aaaatgctag attttccaga tagaacgaaa ttacaaattc tttcaccaat tgttagagga
     8581 caaaaaggta cacataaaaa agtctttgat aatatcaaaa aggaaggatt tgtaagagtt
     8641 agagttaatg gtgaaaacta tgaagttagt gatgatataa tcttaaataa aaatcaaaaa
     8701 cataatatag aagttgtagt ggacagaata gtaattaaag atggaataga atcaagacta
     8761 gcagattcaa ttgaaactgc agttaagcta tctgatggtc ttgtaatagc ccaaataata
     8821 gatggagaag aaattctttt ttcaactaaa tttgcatgcc cagaacatgg aattggcata
     8881 gaagaattat ctccaagaat gttttcattt aatgctccct ttggtgcttg tgatgtttgt
     8941 aatggtcttg gggaaagtaa agaagttgac ccagaattag tagtaccaaa caaagattta
     9001 tcaataaaac aaggtgcagt ggcagcatgg ggttcaacag gtgttaatga tgacacttat
     9061 tacagcaaaa tgataaaaag tttagcagag cattttaatg tatctttgac aacaccgttt
     9121 aaagatttac cagatgattt tgtggaggaa ttactttatg gtaaagataa tataattgta
     9181 gagtttactt atgagtcaaa atttggagga actagaaatt ataaatcata ctttgaaggt
     9241 gtaatagtaa acttagagag aagatataga gaaactaatt cagattacat gagagataag
     9301 attgaagaat acatggcaga gagaccatgt ccaaagtgta aagggatgag acttaaaaag
     9361 gaagttttat ctgttttagt tgatggaaaa aatataatgg aagttacaaa cttatctgta
     9421 aatgaattga ttgactttat ggaaaatata aatcttacag aaaaacagag atttatagct
     9481 catgagatta taaaagagat aaaaggaaga gctatgttct taagagatgt aggtcttgat
     9541 tatttaaatt tatcaagaaa agctggaact ttatcaggag gagaagcgca acgtataaga
     9601 ttagctactc aaataggttc tgcattggtt ggagttttat atgtacttga tgagccaagt
     9661 atagggcttc accaaagaga taatgatagg cttataacta ctcttagaca tctaacagat
     9721 ttaggaaata ccttaatcgt tgtagagcat gatgaagaca caatgagaga agctgattat
     9781 gttatagaca ttggtccagg tgcaggtata catggtggtg aaatagttgc acagggtact
     9841 ttagatgaaa taattgaaaa tgagaactca ataacgggtc aatatttaag tggtaaaaaa
     9901 caaatattgc ttcctgagac tactagagaa ggaaatggaa gttttataga aatagttaaa
     9961 gcatcagaaa ataatctgaa aaatattgat gtaaagttcc cattaggtaa gtttacatgt
    10021 ataacaggtg tttcaggttc cggaaaaagt acattaataa acgatatact ttacaaaggt
    10081 gttgcaagta aagtgaatag acttaagcaa agagctggta agcataagga gataaaagga
    10141 attgaaagta tagataaagt tataaatata gaccaaagtc ctattggaag aacacctcgt
    10201 tcaaatcctg ctacttatac aggtgtattt gattttataa gagatatttt tgcatctact
    10261 aatgaagcta aagcaagagg ttataaaaaa ggtagattta gctttaatgt aaaaggtggt
    10321 agatgtgaag cttgtaaggg tgatggaata ataaaaatag aaatgcattt cttaccagat
    10381 gtatatgttc cttgtgaaat ttgtaaaggt gaaagataca atagagaaac attgcaagta
    10441 aaatacaaag ataaaactat atctgatata ttagatatga atgtggaaga agctgttgag
    10501 tttttcgaaa atataccaaa tataaaaaga aaattagaaa ctttaatgga tgtaggactt
    10561 tcatatatta aattaggaca gccttcaact caattatcag gaggagaagc acaacgtata
    10621 aaattagctg ctgaacttag taaaagacca acaggaaaga ctttgtatat attagatgaa
    10681 cctactactg gacttcatat ggcagatgta gacaagctaa tccaagtatt acaaagacta
    10741 gcagatacag gaaatacaat tatagtcata gaacataatt tagatgttat aaagacttgt
    10801 gattatgtaa tagacttagg accagaaggc ggagataagg gtggaactat agttgcaact
    10861 ggaacaccaa aagaagtatc taaagttgat ggttcttata caggtcaatt cttaaagaaa
    10921 tatttttctt aagttatata aattgtgaaa aattttagag cagatatacg ataaactgtt
    10981 ttgttataag taaattagtc aaatataagt tgtaaatagt aatacaaagt aaagtccata
    11041 ttactcttca tggttaaaat tgttttcaaa tcaattatag aagggaatat gggctttaac
    11101 ttgtttaaag cactggaaat tgtataactt tttaaaattc atattttagg gtataatttt
    11161 agtataaaat ttaatgtttt ggagggcgag atgtttgata tacaagagca tttaaaaaaa
    11221 ttaccttctg agcccggagt atatttaatg aaagacaaat acgaccatat aatatatgtg
    11281 ggaaaagcca tatctctaaa aaatagggta aggcagtatt ttcaatcttc aaaaaaccat
    11341 acatctaaag taaaatctat ggttaagaat atatataagt ttgagtatat tataacggat
    11401 tcagagttag aggcattaat acttgaatgt aatttaataa aaagatacag accaaagtat
    11461 aatgtagtgc ttagagatga taaaacttat ccatatataa aagtaactac gaatgaagat
    11521 tatccaagaa tcttaaaagt tagaagagtt cttaaagata aggcaaagta ttttgggccc
    11581 tataccaata taactgctgt gaatgatacc ttggagctta taagtagtac gtatccaata
    11641 agaagctgta aaatagatat agataaagca ataaagaata agacaagacc ttgtttaaat
    11701 ctacacataa ataaatgttt aggaccttgt acaggaaatg tttctaaaga agagtatgga
    11761 aaaatgatag aagagattat aatgtgttta tctggtaaag aagaaaaatt gatggaactt
    11821 ttaaaggaaa aaatgaatga gagttctatg aactttagat ttgaagaggc tgctgtatat
    11881 agggataaga taaagagcct tgaagagatg atacagaaac aaaaaataga tgctactgta
    11941 agtgacttaa accaagatgt ggttgcaatg gcaagagctc ataatgaagc ttgtgtccag
    12001 gtatttttta taagaaatgg taagattgta ggtagggaac attttatatt agaaggggta
    12061 atggatagtc caagagcttc tatattaagt tcatttgtaa aacaatttta taatgaacaa
    12121 gagtatatac ctaaagaatt aattatagaa gatgagatag aagatagttc tatattagaa
    12181 gaatggctgt catctaaaaa ggggcaaaaa gtaacaataa gagttcctca aaagggagag
    12241 aagaaaagct tagttgaaat ggttaggaaa aatgctgtag aatatcttga aaaattttct
    12301 gatatgaata aaagaaaata tgaaaaaagt attggagcat tggaagaatt aaagcaaata
    12361 ttaaatctag aaaagttgcc aataagaata gaggcttatg atatatcaaa tatacaaggt
    12421 gtagattcga ttggttctat ggtagtgtat acgaatgcta aaaaagataa gaaggaatat
    12481 aggagatata aaataaagac agttattgga cctaatgatt atgattctat ggctgaaatt
    12541 gtagatagaa gattaaaaca tggaaattta cctgacttga tattgttgga tggtggaaaa
    12601 ggacaagtta gtgcagtaaa aaaagtacta gaactcaatg atgtagatat acctctttgg
    12661 ggaatgtaca aagatgataa gcatagaact aaaggattga tatgcaaaga aaaagaaata
    12721 gaactagata aaacaactaa tttatataga tttattgcta gtatacaaga agaagttcat
    12781 aattatgcaa taacatatca tagaagtcta agaaataaag ctttgacaaa atctatctta
    12841 gatgatatac aaggaatagg tgaaaaaaga aagaaatcat tattaaatca ctttaaagat
    12901 gtagatgcta taaaaaaagc tactatggaa gaacttttag aagtagatgg aatgaataaa
    12961 agcattgcag ataatgttta taattttttt agaaaggaag aaaattaatg gaaactagca
    13021 ataaagtatc aataagagag ataataaaag agttgaagtt aaaagtagta tacatgcctg
    13081 atgatgtaga ttattatgtc tactctcaag atataaatag accaggatta cagtttgcag
    13141 gatattttga ttattttgca tatgaaagaa tacaaatagt tggaaagaca gaatataatt
    13201 tttttggatt aatggatagt catattcgag aagaagtact agatagattt ttctcatatg
    13261 aaataccagc gttaataatt tctagagact tggaaatcaa gccagatgta attgaaaagg
    13321 ctaaaaaata taaaagaata cttttgagca caaatagaaa taccactaga cttataaata
    13381 gactgtcaaa ctatttggat aataagttag caccacacac aacaattcac ggggtgctag
    13441 tagatattta tggtataggt gtactgataa aaggtgaaag tagtatagga aagtcggaaa
    13501 cagcattaga actgattcaa aggggtaata gattagttgc agatgatgct gtagaaataa
    13561 gaaaattaga tgaaagtatg cttgtgggtc agtcacctga actaataaga cattttcttg
    13621 agataagagg aataggaata atagatgtta gaagtttata tggagtaggg gcaatcaaaa
    13681 attctaaaat gatagattta gtagttcatt tagaagcttg ggatgaaact aagtattatg
    13741 atagactagg actggataaa gaatatgaag aaatacttgg tgttaatgta gagaaattag
    13801 ttgtacctgt taaacctgga agaaatactg ctatgatatt agaagtagca gcaatgaatt
    13861 ttagacaaag aggaatggga tacgatgcag ctcaagaatt tactaaaaaa ttatcaaaat
    13921 taatcgatac taagtagtac tgaataatag tgaactacac atcatttaat taaatattga
    13981 ttaggattat atcctacacc ttataaatta aaatcaagtt gtatatatat aatgtttatt
    14041 aataagatat attatataag gataatttaa agtacagtgt tagattataa taatactaga
    14101 ttaattttat atttgagttt cattatataa caagaaagtt ggaatttttt atgggaatag
    14161 aatattttag taaactttta gaaagtagta ctgaaaaaga attgctctta agtaaaaagt
    14221 caaataatat aagtacagca agattaatat cttttttgat agtgatagca gggcttgcta
    14281 ttggatttta caataaaaat atagtaggta tttttgttgg agttttatca ataataatat
    14341 ttatagcact cttagttatt catagtaaag taaaagaaga agaaacatat tttaaaagca
    14401 agagcgaagt attaaataag tatattaaga gatttggaga tggttggaag gaatttaaaa
    14461 tagatggaaa agaatactta aaagatgaaa acttgcaagc aaaagattta gacttatttg
    14521 gaagagcatc attgtatcaa tatatctgtg tagctaatac atcttatggg aaaaattttt
    14581 tagccaaata tttgtggaat gaaaatccag atgagaatgt aattttagaa agacagagag
    14641 ctataaaaga acttttatca aaagatgatt tttctattca tattcaaaca ctcagtaata
    14701 taattggtaa agagcaaaaa aataattcag atagtagtat agaatcgttt atagagtatg
    14761 gagaaaataa gaatgtgtat ataccaaaat ggatgcatat ttttacttgg ggtttaccaa
    14821 ctgcaacaat tttatctttt atattttgta tgttaggatt tttacctgtt ttacctgttt
    14881 ttttactttt tataatccag ttagggttta gtggttttgg atatccaaga cttatgcaaa
    14941 ctcttgctcc attattttca tttagtagaa gtatacaagt atatgaaaaa atgtttgagg
    15001 ttttagaaaa agagacgttt gagagtgcat atttgaaaga attacaagat aaactttcta
    15061 agggaagtgg agtttcaaga ggtgttaaac aattaaattc aataggaaat gctgtaaacc
    15121 taaggtataa tcagatacta tatataattg cctgtggtgt tttgatgtgg aactatcatt
    15181 gtgcagaagc tttggagcga tggaaaggta tatatggaaa tcaaattaga gattggtttg
    15241 aatctattgg agaatttgaa gctctaataa gtttaacagt tatttctcat gtaaaggaaa
    15301 atacatgttt tccagtaata aaatatgaag atactccaag attgaaagtt gaagaggtat
    15361 accacccatt aatagcagaa aaaagtgtca tagcaaattc gatacaatta aattctcaga
    15421 cttgtattat cacaggttca aatatgtctg gaaagacaac atttttaaga agtatcggtg
    15481 taaacttagt gctggcatat gcaggtgctc cagtatgcgc taagagtttt gatgcgacct
    15541 gtatggctat atttacttct atgagaatac aagatgatgt aagtcaagga atatcaactt
    15601 tctatgctga gattcttaga ataaaatcaa tgattcaata tagtttaaaa gaactgccaa
    15661 tgttggttct agtagatgaa atttttaagg gaactaactc tgctgataga attattggag
    15721 caagtgaggc agtaaagaaa ttatcaaaac cctgggttat aagtatggtg acaacacatg
    15781 actttgagct atgtgacctt tcaggtagtg gagatgttga agttgtaaac tatcatttct
    15841 cagagtacta tgtagacgat aaaattcatt ttgactataa gataaaagat ggaagatgta
    15901 aaactacaaa tgcaaaacaa cttatgagaa tggcaggtat tctttaatta atagataggt
    15961 taattaaaga ataagtctat ttagaaatat aatttaattt gtgaaattaa taaggattgt
    16021 cttaaattac gtaaaagtat tttaagacaa tcctttttta agaataaatt ttatattttg
    16081 ttatgactac ttagcttctt cacaagcaca ttcttgtgga cactctccat agacacaact
    16141 cttatcaaag taatgagtat gaaggtattt atgggctaca tcactatttg gttctccaaa
    16201 gaagtcttta taaatagctt gtaaatcagg attctcatga gatttacgaa tagccttatt
    16261 tctatctatt tcatataacg catttgcacg tctatcaact atttcagtat taccatggtg
    16321 ataaggttga ccagcacctc caacacatcc accaggacat gccataactt ctatgatatg
    16381 gtatttacat tctccacttc tgaccttatc cataatcttt ctagcgtttt taagtgtatt
    16441 tacaatacac acattaactg tagttccatc aacatctata cttgcttccc taattccttt
    16501 aagacctcta acattagtga agtttacatt atctaaagtc ttattagtta tcttctcata
    16561 tgaagtacgt agggcagctt ctaaaactcc accacttgct ccaaatatag atgcagcacc
    16621 tgtagatttt cctagaggat tatcaaaatc ttggtcttga agattaggta aatcgattgc
    16681 agcttctttt atcatcttag ctaactctct agtagttata gaaaggtcaa catctagtat
    16741 tccagattca cttaattctt ctcttgaagc ttcatatttt ttagctacac aaggcattac
    16801 agatacaaca taaagttctt caggattgat tcctaatatt ttaggtgcat agtagttttt
    16861 agctatagaa ccaaacatac cttgaggaga cttacagcta gatgctaagt ttaacttgtc
    16921 tggataattg tgctctaaga agtttaccca tgcaggacaa caacttgtta atataggaag
    16981 attttcacct ttttggattc tttctataaa ttcagtagct tcttccatta tagtaaaatc
    17041 tgcaccaaag tttgtatcaa atacatgttc aaatccaagt gcttttaaag cagctaccat
    17101 tttccctgta gagattgacc ctggttctaa tccaaactct tcaccaatag caactcttac
    17161 agcaggagca acttgcacta ctatagtctt ttctttttta tttaaaacat cccaaagttt
    17221 aggtacatta tctacttctg ttaatgctcc agttggacag acagatatac attgaccaca
    17281 gaatgtacac tctgtttcaa ccatatcaga gttaaagaat gtactaacta aagtattaaa
    17341 tccacgatta actccagata atgctcctac tgtttgtatg tcattacata cagtctcaca
    17401 tcttctacat aatatacact tagaatggtc tttaactaaa gatttagtag aagtatcttt
    17461 acctgcaaaa gatttagaac cttgatatct tatttttctt actcctaaat cagcagctat
    17521 agtctgtaat tcacaatctc catttttttc acagacaaaa caatcttgtg gatggtctga
    17581 taacaataat tcaacaatag ttctacgagc atttaatgct ttagcactat tagtctgaac
    17641 tttcatacct tcctttataa ctgttccaca agctggaact aatcctctct ctgtctcaac
    17701 catacaaaca cgacaagaag cacaagtgtc aagcttatct atttcattca tatgtaaatg
    17761 acaaaggttg tgtattttta tatttattaa tttcgcagca tctaagatag aagttccact
    17821 aggtgctgaa acgtgtttgc cattaatagt taaattaact aaactcattg ttattcctcc
    17881 tccaaataag ttatttcttg attatagcgt taaatgtaca attatctata caagcaccac
    17941 attttagaca cttagaagta tctattgtat gttgttcctt aacagaacct gttatacaac
    18001 cagcaggaca cactctagaa cattttgtac aacccttaca gtcatctgtt ataaagtaag
    18061 aaagtaagtt ctgacattta ccagcaggac atttcttatc tacaacatga gctatatact
    18121 catctttaaa atattgaaga gtacttaaaa cagggtttgg agcagcttta ccaagaccac
    18181 ataatgaagc agtttgtata gtttcagcaa ggttttctag gtcatctaaa tcttgtagag
    18241 taccattacc ttctgtaatt ttagttaata tttctaataa tcttgtagta cctatacgac
    18301 aaggtgtaca tttaccacaa gattcttcaa cagtaaactc aaggaagaac ttggctatat
    18361 ctaccataca gtcagattca tcaagaacaa gcataccacc agagcccatc attgaaccga
    18421 tagaacttaa tgaaccaaag tctataggag tgtctaaatg ttcagttggt atacatccac
    18481 cagatggtcc acctgtttga acagccttaa atttcttacc ttcagggatt cccccaccaa
    18541 tttcaaatac aatatctctt aaagtagtac ccattggaac ttcaacaagt cctacatttt
    18601 ctacttttcc accaagagca aagactttag taccactaga atcttcagta cctaagttgg
    18661 caaaccaatc tccaccctta agtataattg caggtatgtt agcaaaagtc tcaacgttat
    18721 ttaagcaagt aggagatttc catagaccac tcttagaaga actataagtt ttcattctag
    18781 gttcaccacg tctaccttca attgaatgca ttagcgctgt accttcacca caaacgaaag
    18841 cacctgcacc atattttaat tctaatttaa agttaaatcc agtgcctaag atattttcgc
    18901 caagtaaacc gtatttttca gcttgagcta tggctacttt taatctttct atagattttg
    18961 gatattctgc tcttatgtat atgtatcctg tatcagaacc tatagcgtat ccacatattg
    19021 ccatagcttc tagtacacta tgagggtcac cttcaagtac agatctatcc ataaatgcac
    19081 ctgggtcacc ttcatcagca ttacatacaa caaacttttt atctgttgga ccagctggat
    19141 tttttgaagc agcttcccat ttagagccag tagggaaacc tgcaccacct ctaccacgaa
    19201 ggccagaagt ttttacctct gcaataactt cttgaggagt aagagaagtt aaacatttgc
    19261 ctagagctaa ataaccatca ttggcaatat attcttctat actatctggg tctataagac
    19321 cacaattttt taaagctata cgtaactgtt ttttgtagaa agacatttct tcttgttctt
    19381 caactttttt acttaaagat tcttcctcat ataataattc ctcgacaact gtatttctaa
    19441 ttaagtggct ttgaactatc ttttcagcat cagatggctc aacttttacg tagaaaacgt
    19501 tatcaggata aacttttaca ataggacctt gagcacagaa accaaaacaa cctgtcaaac
    19561 gaacactaac tttatcttgg attcctgatt tctttatttc attttctaat tcactaacta
    19621 tttctagact gtttgaagat gtacatccag tatcacaaca aacaagtaat tctcttctta
    19681 atacattttc cttagaataa ttttttctta agctaagatt aggtttcagc tcatcagcta
    19741 aaacttttaa ttcatcaaat gaatttactt tacgcattat ttattcaccc ctcttaacaa
    19801 ttcaattcta attctctata agtatctaat atttcgctta cttggtcagg tttcacttta
    19861 ccataaactt taccatttac agtaacaact ggagctaaac cacatgcccc caaacatctt
    19921 aaaccttcta aagaaaattt aaaatcacta gtagtttctc caacttttat gccaagctgt
    19981 ttttcaaaag cacttaagat tttgtcagca ccttttacaa aacatacagt tcctagacag
    20041 acactgattt tatacttacc tacaggttct gtagtaaaat aagaatagaa tgtaacaacc
    20101 ccatatacct ttgcaggagc tactccaagt tttctagcaa catgaagttg aacttctttt
    20161 ggaagatatc caaatatacc ttgggcttca tgtagaactt gtattaacgc accttccttt
    20221 gttgcaagag agtcaataaa tatatctagt tcgtcaaata attgcttgtt gtgtgaaata
    20281 aaatcgcaca taacaaatcc cccttttctt tttaaagtta ttatttttca taaaataatt
    20341 aaccatgagt tgaccccaac attatgtggg tgaacaaaac caaaacaata aagaaagaat
    20401 aatatacaac aatttcttta tttataaaaa caatgcaaaa aagttaccta ttaaaaataa
    20461 aaactatact agtctattat aatataaaat aattcagaat agttaaaaaa aataaaaaaa
    20521 atgagctaaa ttcaataaaa aaaaaataat acatataaaa aactttaaaa aataaaccaa
    20581 aatgtaaaat ttttataaaa taaaagattt ataaaactgc tgataatagt cttgaaattg
    20641 attccttgat ttttatataa gtagacctag aattatatat atctaatgtt atttccttag
    20701 aatttaaaat atcattttca aatataattc tttgttccaa tgcttttttt gaagagtaca
    20761 taaatgcatt aacttcgaaa ttaagctcaa aacttctgat atccatatta gctgttccta
    20821 tagagcatat agagtcatct ataactattg tcttagcatg taaaaatgca ttttgaccat
    20881 aagtatagat tttagctcca aactttaaaa gttctccagc atatgaatat gatgcccagt
    20941 atacaaaggg atggtcaggt ttagaaggaa tcatcactct cacatcaaca ccagataaac
    21001 aagctatttt taaagtatct ataaaagttg agtcaagtat taaataagga ctctgtatgt
    21061 atatatactt tctagctttc tgaatcattt taaggtaacc atatttaatc tcatcaagtt
    21121 ctgatatatc tggaccactt gatactatct gaatcccaat attttcagaa ggatgattag
    21181 aatttgtatc ttcttctata aagtattttt ctaaatctaa gtcttcttta gttgtatatc
    21241 tccaatcaag gatgaatctc atatttaggt caattacgca atcaccagta agcttagtat
    21301 gtgtatctct ccatagacca aattttggat ttctacctaa atattcatca ccaacattat
    21361 atccacctac aaatcctacc ttaccatcaa tgacaacaat ttttcggtga tttctatagt
    21421 ttaagttaaa gtttacaatt ttcaagaatg atgggaagaa gcttccaact ttaacaccac
    21481 tttctttaag tctggaaagt gtactatttt ttagtgttct accaccaact gcatcaaata
    21541 aaagtcttac ttcaacacct tctttagctt tgtctataag aatgtctatt atttcagttc
    21601 cgattttgtc atctttgaaa atgtaaaatt gtatgtttat atatttttta gcttttttaa
    21661 gttcttcaag aagactgtta aaaaattgac tagattcagc ataaatccac acatcgttat
    21721 tattggtata atgagcatta tttgaattag ccaatgcata aatcatatcc ttatgttgat
    21781 gtatatctga atcaatttca gatgtagatt ggagtttaac ctgagtatct agtatattac
    21841 ttttgattat cttatcatcc ttttctttca atctaaacat attgtttttt gaaatatttc
    21901 tgccaaaagc tatataaagt atgaatccaa gagcaggaat caatactaat ataagaagcc
    21961 atgttaaagt tgtatttatg tttctttttt ctctaaagat aaggtttagt ataaccatga
    22021 aattaattat atatattgta gtaactgcta tttcatatat tgacatttcg aaaaatgata
    22081 tatcaaacat aaaattccct ccttcaaata tttattaaaa taagtaatta tatataataa
    22141 cac
//
LOCUS       DAEQCW010000062        21746 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.062, whole genome shotgun sequence.
ACCESSION   DAEQCW010000062 DAEQCW010000000
VERSION     DAEQCW010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21746)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21746)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21746
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.062"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            103..1317
                     /locus_tag="KRO40_002298"
     CDS             103..1317
                     /locus_tag="KRO40_002298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBH2093115.1"
                     /translation="MNQEYVKGNPIFTNINKVPRQFPYLTDDIDTDVIIVGGGVTGCI
                     CAYYLAKNNIKSVILEKGRIAHGSTSVTTSLLQYELDDNLIDLTEVMTLKDALKAYNL
                     CTSALEELDTFIELYGNKCDYAKRDTLLYTANKLEVKAIKEEYNLRKENGFDVEYIDE
                     STNPFSFDLKSGLIAKNGGRELDPYKYSHHLIDVSLKNGLQVYENTEVKKVDLSNDKV
                     TAEVSYGYKVHGKKLIVATGYNTSLFTKRNFATKSNTFNIATKPLKNIASWKNNILIR
                     DNCDPYNYLRTTKDNRLIIGGEDVSFDDIENETLANEKYDILEQRLKSMFKDIKDIEV
                     EYKYCGCFASTLDNLGFIGPDNKNNNLWYCLGYGANGILFAILGGIMLSELYLGKQNK
                     NMKLFKVDRFDK"
     gene            1494..3407
                     /locus_tag="KRO40_002299"
     CDS             1494..3407
                     /locus_tag="KRO40_002299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093116.1"
                     /translation="MKYGGIIMKEILVIAPTKGTYEKSIHIVKKNKYTNIDVVFGNLK
                     EGIPLAEKSINHGTRIIISRGGTYNMLKATYNIPIVEIKVDAYDIIKSYKEVKNSNEP
                     FGIIGFNNVIYGFDIIEEILNKKITMIEIEKEEEIYDAIEKYRKKGINTYIGDTTVAH
                     IVKRLNCKGILIESREENILRAIQQAEQILEATKDEQKRRLQIEAMTDFVHDGIITVD
                     KNFKITLFNKSAEKIFGIKKENALYHNVVDVIPNTVLPQVVETMEPQIGEIQNIGSTK
                     IITNRVPIIVDGQIQGAVSTFQDSKEISSFEHTIRRSLLSKGLSAKYTFDDIIHASEK
                     TKDCIELAKKYACYDTPMIITGESGVGKELFCQSIHNYSKRKNAPFVAVNCAAIPPSL
                     IESEFFGYEEGSFTGARKKGKAGVFELAHEGTIFLDEISEIPLELQGRLLRVLQEKQV
                     MRIGGDKVIPIDVKIICASNKDLKNMMRNGLFRQDLYFRINILTLYLPSLKERKEDII
                     KLSEFFIHKYSSKYNKTPLIITPNIKKALLEREYEGNIRELEGMMERAVIVESFDSIL
                     LEKLSNEYTNNIVDKDNSDFECSNLDLKTLEKKYIYKIYNENNRNTTKTCEILKITRS
                     TLWRKLKEIEDDV"
     gene            3678..4652
                     /locus_tag="KRO40_002300"
     CDS             3678..4652
                     /locus_tag="KRO40_002300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBH2093117.1"
                     /translation="MHILKSVKKIPGGLMVCPLLFGALFNTVCPQALEIGGFTTSLFK
                     TGAMSILALFCLCNGAQINIRQAGKPLTKGIVLTATKFIIGAVLGIIVSKFIGPKGII
                     GITPLAIVATMTNSNGGLFAALAGEYGDSTDVGAISILSLNDGPFFTMLAFGVTGLAN
                     VPIVALFAALIPILLGFILGNLDEDIREFLAPGTTLLIPFFAFPLGAALNFNQIITAG
                     LPGVVLGLGVTIITGMGGYFVMKLIRAEHPAVGAATGTTAGNAAGTPEALAAIDPTLA
                     TIAAVSTVQVAAAIIVTAICCPMLVSYLDKREKKKKSIFKTNKNIEVN"
     gene            4673..4948
                     /locus_tag="KRO40_002301"
     CDS             4673..4948
                     /locus_tag="KRO40_002301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH2093118.1"
                     /translation="MNAIIHANEKDNLVTCVRPLIKGEKVSIDGKSYIVNDNIPVFHK
                     MATEDVKKGDVVYKYGEIIGIATVDIKTGDYVHVHNIESTRGRGDKK"
     gene            4961..6124
                     /locus_tag="KRO40_002302"
     CDS             4961..6124
                     /locus_tag="KRO40_002302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBH2093119.1"
                     /translation="MKLMGYLRENGQFGIRNHVLIIPTSVCSSETATRIASLVPGAIA
                     IPHQHGCCQIGSDIELTAKTLIGFGKNPNVAAVLVVGLGCDGIQAKELASEIATTGKK
                     VDYVVIQECGGTLKTVSKGAEIVSKMAREVSKEVRVEFGMSEITLALECGGSDPTSGI
                     ASNPSIGVASNLLVDEGGSSILSETTEVIGAEHLLATRFEDEEMKDKFLKFVSDVEKR
                     AIAMGEDLRSGQPTPGNKAGGLSTIEEKSLGCMYKAGNKPFKGALEYADIVPPDKKGL
                     YFMDTPGQDIDSITGMVAGGAQIVIFSTGRGTPTGSPISPVIKITGNSDTYNKMPDNI
                     DINAGRIITDGAKIADIGQEIFNEIIEVCNGKHTKAESLGHREFGIYRISSTF"
     gene            6461..8740
                     /locus_tag="KRO40_002303"
     CDS             6461..8740
                     /locus_tag="KRO40_002303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2093120.1"
                     /translation="MNFENTKNKKIIATLLLTLLLIVSLTCVTFIMNLNKVTHNETER
                     YLVEVSQSISTTINVKCKSIFRTLYSTGDTYFEINDSEKEVNKYLSKKLQLFEFDWLG
                     IIDSNGNFISALKDTGNVKGQDFYRKALQGKETITPVKSQSGTYGILYSVPLYKGDKI
                     VGAVAAWNTIDTMRNLLSVESFHGEGFSQIIDQDGNFIVSSANKNAPKNVVNFFDMIK
                     HQGKQVDKNKLEEMKINLKKNKTGSIYYTLNDGISKAMHYLPLQEENLYLLSVVPTKT
                     ASAQFDLLLKKAIFINILIVILFLLLIILIMFINQKNRAQLIKIAYVDSVTKGYSKAR
                     FDMEAKKIIQSSSSESYSLVSINIQKFKLINDSFGSEAGDKTLKYIHDVISNYLEPGE
                     LLCRVSNDQFNVLIKTIPQKEILKYIENITNDINSFNKNEECKYFIALSIGVYKIDDP
                     NLPLVSIQDRANVARKNNKGNIGNHPLYTCVFYSDLERLKMIKEKEMENRMEEALNNN
                     EFIVYLQPKISLKDNTIVGAEALVRWQDPNKGLIPPDEFIPFFEKNGFITKLDHYVFE
                     KVCSMIRKWIDNGETPIPVSVNFSRANLNNIDFLEKYRMLRNKYNIPAKLLEIELTET
                     LVFENLQKLINIIDQIHEEGFQCSLDDFGSGYSSLNMLKEIKVDTLKLDRAFFSSPNA
                     DNIAENHVIESIVNLAKKLNMNSISEGVETILQMDYLKKINCDMIQGYVFSKPLPQEI
                     FEKMTFGKKLEETSMDSSV"
     gene            complement(8835..10175)
                     /locus_tag="KRO40_002304"
     CDS             complement(8835..10175)
                     /locus_tag="KRO40_002304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093121.1"
                     /translation="MENQEALRHEKIWILLFRYSIPAIIAMMVTSLYNVVDRAFIGSM
                     EGIGSIAIAGLGVTMPVFTLIIAFGMLVSVGASTRLSIKLGERNREEAEKILGNALTL
                     SIIISLIITILGLVFLEEILFILGASKDSIFYAKDYMSVILVGSIFNLVAFSLNNAIR
                     AEGNPKLAARTMIVGCVLNLILDPIFIFVFNLGIKGAAIATVLCQIVVFFWVIHYFIR
                     GKSNLKLKKCNLKLNKDIVKKVFAIGMTPFAMEVAISITHMFTNNSLKVYGGDLAIGA
                     MTALTSILLMFMMPVFGLNQGMQTIISYNYGAKQYERAKKTLILSIIVSVVILSFGFL
                     VVQVFPEVFVGIFNKDSDLMDIAVRGISLNLITLPIMGISIVGPVYFQCISKVKHSMF
                     LTLLRQFILFIPLIIVLPIQFNLDGVWLAQPVADFIAMIIVLLFLKREFKTSRV"
     gene            complement(10187..10969)
                     /locus_tag="KRO40_002305"
     CDS             complement(10187..10969)
                     /locus_tag="KRO40_002305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004460318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093122.1"
                     /translation="MNCINTKNLNVSYGNTDIIKNLNLNIPKGKITTIIGANGCGKST
                     ILKTIGRIISPNSGKIYINGEDIYKKKSKEIAKDMAVLPQSPQAPSGLTVSELISYGR
                     FPHKSGFGNSSKEDREIVNWSLEVTGIAEFKDRNMEDLSGGQRQRAWIAMALAQETDI
                     LLLDEPTTYLDLAHQLEILKLLDELNKKQGRTIVMVIHELNNAARFADHMIGIKKGKI
                     VCEGDAYDVMTKDNLKELFNIDAEIATDPRTNKPICITYDMV"
     gene            complement(10984..12006)
                     /locus_tag="KRO40_002306"
     CDS             complement(10984..12006)
                     /locus_tag="KRO40_002306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH2093123.1"
                     /translation="MKNIIKINSKTLLVISILMVLIFITFLLSLNMGSFSIEPMDVIK
                     TFLGQGQRNHEIAIFKLRLPRIVIALLVGSALSTAGVILQGVTKNDLADSGILGINSG
                     AALFVVVYIYLMNGNVYEGMSNLTVFTMPIVALIGALFGAFLIYSLAWKGGINSSRLL
                     LIGIGVNIAFTSILTIFQLKFTTQEFNRVMAWTSGSIWGTSWKYVIAVLPFIVIFMGI
                     TIYKSKYIDVLNLGDEVSISLGVDVEKQRRRLIIYAVILSGVSTAVAGSISFLGLIAP
                     HIGRKIIGPKHKRLIPVSALIGTLLLLIADTISRNLLAPIEIPVGIVVSIIGVPYFIY
                     LMLVND"
     gene            complement(12012..13025)
                     /locus_tag="KRO40_002307"
     CDS             complement(12012..13025)
                     /locus_tag="KRO40_002307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBH2093124.1"
                     /translation="MTKLSKKNITYLLILVSIVVLVFGIVLSITIGAKDMNLSTVIDS
                     LIKMEDGINMRIVKDVRLPRAIAAALVGGFLAVSGAIMQGITRNPIAEPSVIGITQGA
                     TFAISISLVLQKKLPQLIHGSFSVMMFAFIGASISGLFIYFISSKSRGRVNNVKLALA
                     GVALGTLLISLASAISMYFNLSQQLSFWISGGLVGVKWEGIKLLFIAGGIGFILAIIM
                     APRITILSLGEEVAIGLGQKTNFVRFICIVLVILMTGASVSVSGNIIFIGLIVPQIAK
                     GIVGSDYKYIIPSSLVLGAVLLVYTDILSRMINPPYETPVGSITALIGVPIFIYLVRK
                     GEK"
     gene            complement(13153..14091)
                     /locus_tag="KRO40_002308"
     CDS             complement(13153..14091)
                     /locus_tag="KRO40_002308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2093125.1"
                     /translation="MKKIKSLAIFISIITTLVLVTACSDKNTEDKDKSETRVVQSVKG
                     EVKIPSNPKKIVDISGSSEELLLAGYKPVATANVDSYETDKLPSYIREELKGVKIVGH
                     SMMDTMDMEAILEVNPDLIIMSQRQEKIYDQLKEIAPVVMMKDYANDWRSKLTDVSKL
                     FDKEEEAKSWLQKYDEKATKLGKEVIEKNGEKTYLPVLASSGQFMVFSDGGIGTLIND
                     DMKLARPKNMPKQDGITLPMVSMEGLTDIDADHIVVIATESDKKDLENSAIWAQIRAV
                     KDGNVTILDAAPFFSQSYNPIGKELLLESVKNELTK"
     gene            14361..14825
                     /locus_tag="KRO40_002309"
     CDS             14361..14825
                     /locus_tag="KRO40_002309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016208838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093126.1"
                     /translation="MVHLVYCDNAGKKGEKVLDKILAGTKTMVIRGAAGRKIPHSRVF
                     EDELLYFMEKGTAKISAKATVKKVENYVKLTEDEISKILNENQPKLNLSEKQKVRWHK
                     KCLCLVEFENVEEITPLDFDHQGNMDDWLIVEKIEDVVVGTSIPYNYEKSKF"
     gene            complement(14937..15254)
                     /locus_tag="KRO40_002310"
     CDS             complement(14937..15254)
                     /locus_tag="KRO40_002310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBH2093127.1"
                     /translation="MDEKMIEISFGIIGFAGDAKGLAFEAIKEAKSGNIDKARECIEK
                     SKESIHKAHKFQTELIQNEANGNKTEISVILIHAQDHLMTAMNFQQLAEEFIDVYERL
                     ESK"
     gene            complement(15267..15998)
                     /gene="chbG"
                     /locus_tag="KRO40_002311"
     CDS             complement(15267..15998)
                     /gene="chbG"
                     /locus_tag="KRO40_002311"
                     /EC_number="3.5.1.105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chitin disaccharide deacetylase"
                     /protein_id="HBH2093128.1"
                     /translation="MTKIIINADDFGYCEAVNYGIISAHNNGIVRSTSMMANMPGVEH
                     GVGLLKENKTLNCGVHMTLSCGRPLLSNLKTIVDKDGFFIRRITDEIIEKMDCDEIYR
                     ELCAQIDRVKGLGIDISHLDSHHHIHTLVSLKPVIEKIVTKYNLPIRGGFEYNLEYSK
                     VVPLIDSFYKENVSEEYFIKNIDEIMKYDVVDIMSHPAFLDDYILNSTSYAIDRTKEH
                     KILTSKKVKEFLEKNGLVISSYRDI"
     gene            complement(16024..17334)
                     /locus_tag="KRO40_002312"
     CDS             complement(16024..17334)
                     /locus_tag="KRO40_002312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBH2093129.1"
                     /translation="MKKGLKIVTIGGGSSYTPELVEGFINRYEELPVKELWLVDIEAG
                     KEKLEIVGNLAKRMVKKAGVDMKINLTLDRREALRDADFVTTQLRVGLLDARIKDETI
                     PLSHGVMGQETNGAGGLFKALRTIPVIFDIIKDVEELCPNAWMVNFTNPTGIITEAVF
                     KYTNFRRYIGLCNVPIHLKNDVAKLFNVESDRISMDFAGLNHMVYGLNVSLDGEDVTK
                     EAIDKFVKADISMQNIKAIDFNAEFVKSLGAIPCPYHRYYYKTKEMLEDELREFKEGK
                     ARGQVVKELEEQLFELYKDEKLDVKPPQLEKRGGAYYSDAACNLISSIYNDKKDIQVV
                     NTLNKGSIRDFKDEQAVEVSSVITKNGPKPISIGYLPDSVHGLVSQIKSFEVLAAKAA
                     VYGDYESALLALCINPLIPSDDLAKTILDEMLEAHKDYLPRFNR"
     gene            complement(17431..18744)
                     /locus_tag="KRO40_002313"
     CDS             complement(17431..18744)
                     /locus_tag="KRO40_002313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2093130.1"
                     /translation="MEKFMSFMDKYIVPVAAKIGAQRHLVAVRDAFIVMIPITMVGAL
                     GTLINNLPLEAYKNLMASIFGENWTTFGGDLWWGAIGTMAVFLVIGVAYFLAKSYESD
                     GLQSGLIALSIFFIMAPQIGKIVPEGGTTVVEGWGMIQQTYLGTAALFSSILIGLLST
                     EIFVRLSKVKKLTIKMPDGVPPAVSRSFAKLIPGMLTIMIFTVIGIFIKMLSNGSFLT
                     DILNTYLGAPLSNVADSLGSTMLIAFIIHILWTVGLHGANIALPFTETILMKLGGENA
                     ALAQAGATEGYHVLAGAFFDAFVYLGGSGMVLGLIVALLIAGRRRKEMIVLGGPPAIF
                     NIGEPLIFGLPIVLNPIFMIPFVLAPVICSAVSYLAIDFGLVAPVILPKIPWVTPPIL
                     GGAMATGDWTGGALALFNLILSILIYIPFVIASEKMEANKLKINN"
     gene            complement(18766..19077)
                     /locus_tag="KRO40_002314"
     CDS             complement(18766..19077)
                     /locus_tag="KRO40_002314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2093131.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMEDAAKENGIEAKIWAISEVNLKN
                     EIENCDVLLLGPQVRYVLGKATEMAKPYNIPVEVINMMDYGRCNGKAVLDRAVELNSS
                     K"
     gene            complement(19277..19981)
                     /locus_tag="KRO40_002315"
     CDS             complement(19277..19981)
                     /locus_tag="KRO40_002315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093132.1"
                     /translation="MKEPIYKVIENHVRELINSDSLKEGDLIPSEKQLSEEFNVTRMT
                     VRSALNNLVKEGYITRQRGVGSIVIANNIYDNISSVSGFTKEMESKGYKVSNILVSLE
                     IVQADENLSSKLNISLEENVWEIKRVRLANDARVSYMITYMPVKLFPNLNKTHCENSL
                     YNFVEEVCGYKIAMSEREVQAVISNEECMDNLKLEEPEPLLYISQICKLQNSEIFEYS
                     HTYHYGYTLTLNAVVE"
     gene            complement(20072..21433)
                     /locus_tag="KRO40_002316"
     CDS             complement(20072..21433)
                     /locus_tag="KRO40_002316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093133.1"
                     /translation="MKDRLNLTEGRITEKLLKLSLPIMGTSFIQMGYNMIDMIWVGKA
                     GSKAVAAVGTAGFFPWLAMAFIMISKVGGEIKVAQSIGANNISTTKSYMKSAIEINII
                     LAIIYTISLIVLNKQLIGFFRLGDLEVITMSRQYLIIVALGMVFYFINPVFTAIFNGL
                     GNSKTPFRINTVGLITNIILDPILIFGWGFAPKLGVAGAAIATVFAQIVVTTCFIYII
                     VKSKEEYFKLRLFKEIETKYYKVLYKLGLPIAIQSGMFTVFSMLLGVIVASWGPVAVA
                     VQKVGSQIEAISWMTAEGLSVALGSFVGQNYGAKKYSRINKGCKIAITVSSVLGIITT
                     LVLVFAGESIFSIFIDESEAIEKGAVYLKILGYSQFFMCLEIITTGAFKGLGRTYIPS
                     IIITILTGARVPLAYFISRPEMLGLNGVWWSITLSSILKGILMISLFISLLKLGKLYK
                     ISE"
BASE COUNT         7735 a         3516 c         2886 g         7609 t
ORIGIN      
        1 tttatctata catacccata taactagata attaaaatgt ataatattat ttgctataga
       61 aaataataca ctcatacata ataaatttta ggagtgaagt atatgaatca agaatatgta
      121 aaaggaaatc ctatttttac taatattaat aaagttccaa gacaatttcc ataccttact
      181 gatgatattg atactgatgt tataattgtt ggtggtggcg taactggatg tatctgtgct
      241 tactatctag ctaaaaacaa tataaagtct gtcattcttg aaaaaggaag gattgcacat
      301 ggaagcacta gcgtgacaac ttctctatta cagtatgaat tagatgacaa tttgatagat
      361 ttaacagagg ttatgactct aaaagatgct ctaaaagcat ataacctttg tacttcagca
      421 cttgaagaat tagatacatt tatagagcta tatggaaata agtgtgatta tgccaaaaga
      481 gatactctac tttatactgc caacaaactt gaagttaagg ctatcaaaga agaatataac
      541 ttaagaaaag aaaatggatt tgatgttgaa tatattgatg aatccacaaa cccttttagc
      601 tttgatttaa aatcaggatt gatagcaaag aatggaggac gagaattaga cccatataaa
      661 tatagtcacc atttgattga tgtaagttta aaaaatggtc ttcaagtata tgaaaataca
      721 gaagtaaaaa aagtagattt atcaaatgat aaggttactg ctgaagtatc gtatggatac
      781 aaagttcatg gtaaaaaatt aattgtagct acagggtaca atacaagttt atttacaaaa
      841 agaaattttg caactaagtc aaatactttt aatatcgcaa cgaaaccact taaaaacata
      901 gcttcttgga aaaacaacat tttaattaga gataactgtg acccatataa ttatctaaga
      961 actactaaag acaatcgatt aattataggt ggtgaagatg taagttttga tgatatagaa
     1021 aatgaaactt tagccaatga aaagtacgat attttagaac aaagattgaa aagtatgttt
     1081 aaggatataa aagacattga agttgaatat aaatattgtg gttgttttgc ttcaacttta
     1141 gataatttag gttttattgg tccagataat aaaaataaca atctatggta ttgcttaggt
     1201 tatggagcaa atggtatact ctttgcaata ttaggaggta taatgttaag tgaattatat
     1261 cttggcaaac aaaataaaaa tatgaaatta tttaaagtag atagatttga taaatagata
     1321 ttatatatta aaagactgta aaaagatgaa actttataat tctaaaagtt aactttgata
     1381 cagtctttta taatgttcct tttaaaaata ctttatttat aattaaatat aaagtaaaat
     1441 gttaaaatat aactaataaa atttagtcat aagataatat ttaagtttat ttgatgaaat
     1501 atggaggaat tattatgaag gaaatactcg ttattgctcc cactaaagga acctatgaaa
     1561 aatcaattca catagttaaa aaaaacaaat atacaaatat tgatgttgta tttggcaatc
     1621 taaaagaagg tatacctctt gctgaaaaaa gtattaatca tggtactaga attatcataa
     1681 gccgaggtgg aacttacaat atgttaaaag ctacttacaa tatacctata gttgaaatta
     1741 aggtagatgc ttatgatatt ataaaaagct acaaagaggt aaaaaattcc aacgaaccat
     1801 ttggaataat tggatttaat aatgtcatct acggtttcga tattatagaa gaaatattga
     1861 ataagaaaat aactatgatt gaaattgaaa aagaagaaga aatttatgat gctatagaaa
     1921 agtacagaaa gaaaggtata aacacatata taggagatac cactgttgca catattgtta
     1981 agagacttaa ttgtaaggga atattaatcg aatctagaga agaaaacata cttagagcca
     2041 ttcaacaagc agagcaaata ctcgaagcaa ccaaggatga acaaaaaaga agattacaga
     2101 tagaagctat gacagatttt gtacatgatg gaataataac agttgataaa aattttaaaa
     2161 taacattatt taataagagt gctgaaaaaa tatttggtat aaaaaaagaa aatgcacttt
     2221 atcataatgt tgtagatgtt atcccaaaca cagttcttcc acaagtagtt gagactatgg
     2281 aacctcaaat tggtgaaata caaaatatag ggagtacaaa aattattaca aatagagttc
     2341 caatcattgt tgatggtcag attcaaggag ctgtttcaac atttcaagat agcaaggaga
     2401 taagttcttt tgaacataca ataagaagga gcttattaag caaaggtcta tctgctaaat
     2461 acacttttga tgatataatt catgctagtg aaaagacaaa agattgtata gaacttgcaa
     2521 aaaaatatgc ttgttatgat actcctatga ttattactgg agaatctgga gttggtaaag
     2581 aactattttg tcaaagtata cataactata gtaagcgtaa aaatgcacct tttgttgctg
     2641 taaattgtgc tgccatacct ccatctctaa tagagagtga gttttttggt tatgaggaag
     2701 gttcatttac aggtgctaga aaaaaaggta aagcaggtgt attcgaacta gcacatgaag
     2761 gcacaatctt cctagatgaa ataagtgaaa tccctcttga acttcaaggt cgattattga
     2821 gggtattgca ggaaaaacaa gttatgagaa ttggtggtga taaagttatt cctatagatg
     2881 taaaaattat ctgtgcttca aataaagact taaaaaatat gatgcgcaat ggtttattta
     2941 gacaagacct ttattttaga ataaatatac taacattata tcttccttca ttaaaagaaa
     3001 gaaaagaaga tattataaaa ttatcagaat tttttataca taaatattca agcaaataca
     3061 ataaaacgcc tttaattatc actccaaata ttaaaaaggc acttcttgaa cgagaatatg
     3121 aaggtaatat aagggaattg gaaggtatga tggaaagggc tgttattgtg gaatcatttg
     3181 actcgatttt attagaaaag cttagcaatg aatatacaaa taatatagtt gataaagata
     3241 atagtgattt tgaatgcagt aatttagatt taaaaacttt agaaaaaaaa tatatctata
     3301 aaatttataa cgaaaataat agaaatacta caaaaacctg tgaaattcta aagataactc
     3361 gctccactct atggcgtaag ttaaaagaaa tagaagatga tgtttaaaaa taatacatat
     3421 ctatatatat caaaacgttt tatgtttaat tttaatacat aagacgttta tttgttttca
     3481 ataaaaaata caattatatg ataaaaagaa tctttgtaag tgaaattctc gtcaatcata
     3541 cttttaatta taagtaatct acagcatttc aatcgattat taaaaataat cataataact
     3601 aaagatacaa actctatata ttggcatagt aattgctttt ataataccta tataaaaatg
     3661 aaagggagtg atactagatg cacatcttaa aatcagtgaa aaagatacca ggaggactta
     3721 tggtctgtcc cttgttattt ggagcactat ttaatacagt atgtccacaa gctcttgaaa
     3781 ttggaggatt cacaacatcc ttatttaaaa ctggtgcaat gagtatactt gctctatttt
     3841 gtctatgcaa tggagctcaa atcaatatca gacaagctgg taaaccattg actaaaggta
     3901 tagtacttac agcaacaaaa tttataattg gtgcagtatt aggtattatt gttagtaaat
     3961 ttattggacc taaaggtata attggtatta cacctcttgc catagttgct accatgacta
     4021 attcaaatgg aggtctattt gctgctcttg caggtgaata tggagactcc acagatgttg
     4081 gagcaatatc tatcttatct ctaaatgatg gtcctttttt tacaatgctt gcttttggag
     4141 taactggact tgcaaatgta cctatagtag cactatttgc agcacttata ccaatactac
     4201 ttggatttat acttggtaac cttgatgaag atatacgaga atttcttgca cctggtacaa
     4261 cattattaat tcctttcttc gcttttcctt taggagcagc attaaacttt aatcaaatta
     4321 taactgctgg actacctgga gttgtacttg gtttaggagt tactataata acaggtatgg
     4381 gtgggtactt tgtaatgaaa cttatacgtg cagaacatcc agcagtaggt gcagctacag
     4441 gtacaacagc cggaaatgca gctggtactc ctgaagcttt agcagctata gaccctactc
     4501 tagctacaat agcagctgtt tcaacagtac aagttgctgc tgctattatt gttacagcaa
     4561 tatgttgtcc aatgttagtt tcctatctag ataaaagaga aaaaaagaaa aaatctattt
     4621 ttaaaacaaa taaaaatatt gaagtaaatt aatacttaag gaggtaaaat taatgaatgc
     4681 aattattcat gcaaatgaaa aagataatct agttacatgt gtcagacctt taattaaagg
     4741 tgaaaaagtt tcaattgatg gaaagtctta catagtaaat gataatatac ctgtctttca
     4801 taagatggct acagaagatg taaaaaaagg tgatgttgta tacaaatacg gtgaaattat
     4861 aggaattgca acagttgaca taaaaactgg tgactatgtt catgtacata acattgaaag
     4921 tacacgtggt cgtggagata aaaaatagga ggaagttaaa atgaaattaa tgggttattt
     4981 aagagaaaat ggtcagtttg gtattcgtaa tcatgtttta attattccaa catctgtatg
     5041 ttcaagtgag acagctacaa gaatagcatc acttgtgcct ggagcaatag caatccctca
     5101 tcaacatgga tgttgtcaaa ttggttctga tatagaactt acagcaaaga cattaatagg
     5161 atttggaaaa aatcctaatg ttgccgcagt tttagtagtt ggtcttggat gtgatggtat
     5221 tcaagcaaaa gaattagcat ctgaaatagc tacaacagga aaaaaggtag attacgttgt
     5281 tatacaagaa tgtggtggaa cattaaaaac agtttctaag ggagctgaaa tagtaagtaa
     5341 aatggctcgt gaagtatcaa aagaagtaag agttgaattt ggtatgagtg aaattacatt
     5401 agcacttgaa tgtggtggtt ctgacccaac aagtggaata gcttcaaacc cttcaatagg
     5461 cgttgcatca aaccttcttg tagatgaagg tggaagtagc atactaagtg aaactacaga
     5521 agtaattggt gcagaacatt tgttggctac ccgttttgaa gatgaagaaa tgaaagataa
     5581 gtttcttaaa tttgtaagtg atgtagaaaa aagagcaatt gctatgggag aagatttacg
     5641 tagtggtcaa cctactccag gcaataaagc tggtggactt tcaacaattg aagaaaagtc
     5701 acttgggtgt atgtataagg caggcaataa gccattcaaa ggtgctcttg aatatgctga
     5761 tattgtacct cctgataaaa aaggattata ttttatggat actccaggtc aagatataga
     5821 ttctatcact ggtatggtag caggtggtgc acaaattgta atcttttcaa ctggtagagg
     5881 tactccaaca ggaagcccta tttcaccagt tattaaaatc actgggaata gtgatacata
     5941 caacaaaatg ccagacaata tcgatataaa tgcaggtaga attataacag atggtgctaa
     6001 aatagcagat ataggtcaag aaatatttaa tgaaataata gaagtctgta atggtaaaca
     6061 taccaaagct gaaagtcttg gtcatagaga atttggcatt tacagaattt catctacatt
     6121 ttagattgta acaaaatatc ttttataaat ataatactta tgtagataca taagctaaaa
     6181 gttctttcta atcctataaa aattttctat actgaaaagg aactgtatca aaattatttt
     6241 gaaaatagtt ccttttttca cctcttttac tcaaaatatt ataaaataag atttaaacaa
     6301 taaacgtatc ttgattaatc tctaagaaga cataaataaa gctaaatgta aagtgagata
     6361 aataaaattt aatatctttg tatgaaaaga tatttggtat aatatgtctg agagaattct
     6421 tatttgtaaa caaataaagg atggaggatg aaacaaaaga atgaactttg aaaacacaaa
     6481 aaataaaaaa ataatagcta ctttactatt gacactcctt ttaatcgtgt cattaacatg
     6541 tgtcactttt attatgaatc taaataaagt aacacataat gaaacagaac gatatcttgt
     6601 agaagtttca caaagtattt ccactacaat taatgtgaaa tgtaaaagta tatttaggac
     6661 actatattct acgggagata cttattttga gattaatgat agtgaaaaag aagtcaataa
     6721 atacttatca aaaaaattac aattatttga atttgattgg ttaggtatta tagattcaaa
     6781 tggaaatttt ataagtgccc ttaaagatac aggtaatgtt aaaggacaag acttttatag
     6841 aaaagccctt caaggtaaag aaacaattac tcctgttaaa tcacaatctg gtacatatgg
     6901 aattttatat tctgtaccac tatacaaagg tgataaaatt gttggagctg ttgctgcttg
     6961 gaatactatt gatactatga gaaatttatt aagtgtagaa agctttcatg gtgaaggatt
     7021 ttcccaaatt atcgaccaag atggaaattt tattgtaagt tcagcaaaca aaaatgctcc
     7081 aaaaaatgtg gtgaattttt ttgacatgat taaacaccaa ggaaaacagg ttgataaaaa
     7141 taaacttgaa gaaatgaaaa taaacttaaa aaagaacaaa actggttcta tatattacac
     7201 attaaatgat ggtatttcta aggcaatgca ctatcttcca ttacaagaag aaaatttata
     7261 cctcctttca gttgttccaa caaaaacagc aagtgcacag tttgatttac ttctaaaaaa
     7321 agcaatcttc atcaatattt taattgttat actattttta ttgcttatta tattgattat
     7381 gtttataaat caaaaaaaca gggcacaact tataaaaatc gcctatgtag actctgtaac
     7441 taaaggttac agtaaagcac gttttgatat ggaagctaaa aaaattatac agtcatcttc
     7501 atcagaaagc tattcattag tatctataaa tattcagaaa ttcaaactta ttaatgattc
     7561 ttttggtagt gaagcaggag ataaaacatt aaagtacata catgatgtca ttagtaatta
     7621 tctagaacca ggagaattac tttgtcgagt ttctaatgac cagtttaatg tacttattaa
     7681 aactattcct caaaaagaaa ttcttaagta catagaaaat atcaccaatg atattaatag
     7741 tttcaataaa aatgaagaat gtaaatactt tatagctcta tctataggtg tatataaaat
     7801 tgatgaccca aatctacctt tagtttcaat tcaagaccgt gcaaatgttg cacgaaaaaa
     7861 taataaagga aacattggaa atcatccact ttatacatgt gttttttata gtgatttaga
     7921 gcgtttaaaa atgattaaag aaaaagaaat ggaaaataga atggaggaag cattaaataa
     7981 taacgaattt atagtatatc ttcagcctaa aataagcctc aaagataata ctattgtagg
     8041 tgcagaagca ttagtaagat ggcaagaccc aaataaaggt cttataccac cagacgagtt
     8101 tattcctttc tttgaaaaaa atggttttat tacaaaactc gaccactatg tttttgaaaa
     8161 agtatgcagt atgataagaa aatggataga taatggagaa actccaatac ctgtttcagt
     8221 taatttttca cgtgctaatt taaataatat agatttttta gaaaaataca gaatgcttcg
     8281 taataaatac aacattcctg ctaagctctt agaaattgaa ttaactgaaa cacttgtatt
     8341 tgaaaatctc caaaaattaa ttaatataat agaccaaatc catgaagaag gttttcaatg
     8401 ttcactagat gactttggaa gtggatactc ttcactcaat atgttaaaag aaataaaagt
     8461 tgacacatta aaacttgacc gtgctttttt tagctcacct aatgcagata atattgctga
     8521 aaatcatgta atagaatcta tagttaattt ggcaaaaaaa ttaaatatga atagtatatc
     8581 agaaggtgtt gaaacaatct tgcaaatgga ttatcttaaa aaaattaatt gtgatatgat
     8641 acaaggatat gttttttcaa aacctctacc tcaagaaata tttgagaaaa tgacttttgg
     8701 aaaaaaacta gaagaaacca gtatggatag ttccgtttaa ataaaataaa aaacttgtct
     8761 ctataaaata attttaatca ttttataaag acaagtcttt ttattttcca atttaatttt
     8821 attttctaaa tttcttacac tcggcttgtt ttaaattccc tttttaagaa taataatacg
     8881 attatcatag caataaaatc tgcaactggc tgtgccaacc aaacaccatc taaattaaat
     8941 tgaattggaa gtacaatgat taatggtata aataaaataa attgtcttaa aagagttaaa
     9001 aacattgaat gtttaacttt acttatacac tgaaaataca caggtcctac aatagaaatc
     9061 cccattatag gcaatgtaat tagatttagg cttatacctc ttactgctat atccatcaaa
     9121 tctgaatctt tattaaatat acctacaaat acttctggga aaacttgtac tactaaaaat
     9181 ccaaatgaca atatgacaac tgacactatg atagataata ttaaggtttt ctttgcacgc
     9241 tcatattgtt ttgcaccata attgtatgat attatagttt gcataccttg attcaatcca
     9301 aacacaggca tcataaacat caataaaata gatgtaagtg ctgtcatagc tccaatagct
     9361 aaatctccac cataaacctt tagagaatta tttgtaaaca tgtgagttat acttatagct
     9421 acttccatag caaaaggtgt cattcctatt gcaaatacct tctttactat atctttattc
     9481 aattttaagt tacatttttt tagttttaaa ttggacttcc ctcttataaa ataatgtatt
     9541 acccaaaaaa atactactat ttgacagagt actgttgcta tagctgctcc ttttatacct
     9601 aaattaaata caaatataaa tatagggtcc aatatcaggt ttaatacaca tcctacaatc
     9661 attgtccttg ctgctaattt tggattacct tctgccctaa ttgcattatt aagagaaaat
     9721 gcaactaaat taaatatact tccaaccaat atgacactca tatagtcttt tgcataaaat
     9781 attgaatctt tacttgcacc caaaataaaa agtatctctt ctaagaaaac taatcctaat
     9841 atagttataa ttaaagagat aattatagat aatgtcaagg cattacctaa tatcttctct
     9901 gcttcttctc tatttctttc ccctaacttt atagacaatc ttgtgctagc acctactgat
     9961 accaacattc caaaagctat tattagagta aatactggca tagttacacc aagacctgca
    10021 atagctatag agccaatacc ttccatagaa ccaataaaag ctctatctac tacattataa
    10081 agtgaagtta ccatcattgc tattattgca ggtatcgaat acctaaataa taaaatccat
    10141 attttttcat gtcttaatgc ttcttgattc tccatgttgt caccatttac accatgtcat
    10201 aagttataca aattggttta tttgttcttg ggtctgttgc tatttctgca tcaatattaa
    10261 ataattcttt tagattatcc ttcgtcataa catcatatgc atcaccttca caaactattt
    10321 tacctttctt aatacctatc atgtggtcag caaatcttgc tgcattatta agttcatgta
    10381 ttaccatgac aatagttctt ccttgttttt tatttagttc atctaataat tttagtatct
    10441 ccaattgatg tgccaaatct aaatatgttg taggctcatc cagtaataat atatcagttt
    10501 cttgtgccaa agccatagct atccatgccc tttgtctttg tcctcctgat aaatcttcca
    10561 tatttctatc cttaaattct gcaattccag taacttctaa actccaattt acaatctctc
    10621 tgtcttcttt actagaatta ccaaatccac ttttatgagg aaatcttcca taagaaatta
    10681 attctgaaac ggtaagacca ctaggagctt gagggctttg tggaagtaca gccatatctt
    10741 ttgctatttc tttagacttc tttttgtaga tgtcctctcc atttatatat attttcccac
    10801 tattagggct aataattcta cctatagttt taagtattgt cgattttcca caaccattag
    10861 cccctatgat ggtagttatt tttccttttg gtatatttaa atttaaattt tttataatat
    10921 ctgtgtttcc atatgataca tttagattct tagtatttat acagttcata acaacaccct
    10981 ttcctaatca tttaccaaca ttaaataaat aaagtacggc actcctatta tagaaactac
    11041 tatgcctact ggtatttcta taggtgctag aagatttctt gatatagtat ctgctattaa
    11101 aagtaataat gttcctatca atgctgatac tggtattaat cttttatgct ttggtcctat
    11161 tatttttcta cctatatgtg gagctattaa acctaaaaat gaaatactac ctgctactgc
    11221 tgtcgataca ccagataaaa ttactgcata tattataagt cttcttcttt gtttttctac
    11281 atctacacca agacttatag atacttcatc acccaaattt aaaacatcta tatatttaga
    11341 tttataaata gttataccca taaaaatcac tataaatgga agcacagcta ttacatattt
    11401 ccaactggtt ccccaaatgc ttcctgatgt ccatgccata accctattaa attcttgtgt
    11461 tgtaaatttc aattggaata tcgtcaaaat tgaagtaaaa gctatgttta cacctatacc
    11521 aataagtagt aatcttgacg aatttatacc acctttccat gcaagagaat atataagaaa
    11581 tgctccaaat aaagctccta taagtgcaac aataggcatt gtaaatacag tcaagttact
    11641 cataccttca tatacattac cattcataag gtatatataa actactacaa acaatgcagc
    11701 acctgaattt attcccaaaa ttccagaatc agctaaatca ttctttgtaa ctccttgaag
    11761 tattacacct gctgttgata atgcagaacc aaccaaaagt gctattacta ttcttggtaa
    11821 tcttaattta aatattgcaa tttcatgatt acgctgaccc tgccctaaaa aagtctttat
    11881 aacatccatt ggttctatag aaaatgagcc catatttaaa ctcaataaaa aagtgataaa
    11941 aataagcacc attaaaattg atataacaag taatgtttta gaatttattt ttataatatt
    12001 tttcatagta cctatttctc cccctttcta acaaggtata taaatattgg cactcctata
    12061 agtgctgtta tagaacctac tggtgtctca tatggaggat ttatcatcct acttaatata
    12121 tctgtatata caagcaatac agctcctaat actaaagagc tcggtattat atacttataa
    12181 tctgaaccta ctattccttt agctatttga ggaactataa gacctataaa aataatatta
    12241 ccagacactg acacagatgc tccagtcatt aatattacaa gtactataca tataaatcta
    12301 acaaagttag ttttttgtcc taatcctatt gccacttctt ctccaagact taatatagtt
    12361 attcttggag ccataataat agctaaaata aatccaatac ctccagctat aaatagcaat
    12421 tttatacctt cccacttcac tcctacaagc cctcctgata tccagaaact caactgttga
    12481 gataggttaa aatacataga tattgctgat gccaaagaaa ttaacaatgt accaagagct
    12541 actcctgcaa gtgctagttt tacattatta actcttcctc ttgatttaga acttataaaa
    12601 tatataaata atccacttat acttgcccca ataaatgcaa acatcattac actaaaactt
    12661 ccatgtataa gttgaggaag ttttttttga agtaccagtg atatcgaaat tgcaaatgta
    12721 gccccttgtg taattcctat aacagatggt tcagctatag gatttctcgt tattccttgc
    12781 attattgccc cggaaactgc taaaaaacct ccaacaagtg cagctgctat tgcccttgga
    12841 agtctaacat cctttactat tctcatattt attccatctt ccatttttat caagctatct
    12901 ataacagttg atagattcat atcttttgcc ccaatagtta tggataatac aattccaaat
    12961 acaagtacaa ctatacttac taatatcaac aaataagtta tatttttttt acttaactta
    13021 gtcaattatc ctacctcctt ttccctttta atcgtcagta taatatcatc tattaagtat
    13081 tttaatttta agctttatta aaaataggtg tgaaaaatga atatcattat ctcacaccta
    13141 ctaagttaag aattactttg ttaattcatt tttaactgat tctaataata actcttttcc
    13201 aattggattg tatgattgac tgaaaaatgg agcagcgtca agtattgtta cattgccatc
    13261 ttttactgct cttatttgag cccagatagc actattttct aaatcttttt tatctgattc
    13321 tgtagcaatt acaactatat ggtctgcatc tatatctgtt aaaccttcca tacttaccat
    13381 tggtagtgtt attccatcct gttttggcat attcttaggt ctagctaatt tcatatcatc
    13441 attgattaga gtacctattc caccatcgct aaataccata aattgacctg aacttgccaa
    13501 cactggtaaa taagtttttt ctccattctt ttctataact tccttaccta actttgtagc
    13561 tttttcatca tacttctgta gccaactttt agcttcttct tctttgtcaa ataactttga
    13621 aacatcagtt aacttgcttc tccagtcatt tgcataatct ttcatcataa ctacaggagc
    13681 tatttctttt aattggtcat atattttttc ttgtctttga ctcattatta ttaaatcagg
    13741 atttacttct aatatagctt ccatatccat agtatccatc attgagtgcc caactatctt
    13801 tacaccttta agctcttctc ttatgtaact tggtaattta tcagtttcat atgagtctac
    13861 atttgctgtt gcaacaggct tataacctgc taataatagt tcttcactac ttcctgatat
    13921 atcaactatt tttttaggat ttgatggtat cttaacctct cctttaacag attgtacaac
    13981 tcttgtctct gatttatctt tatcctctgt attcttatct gaacatgctg taacaagtac
    14041 taatgtagtt ataatagata taaatattgc aagtgatttt atttttttca tgattacttc
    14101 tcctacttgt ttattatact tacatgatat tgattatcat aagcacatat ttattatagc
    14161 atttttctat ttttagtcaa tattattttg taaaaggata aaaattccta attaatctta
    14221 attatatata gcttagataa ggttttctta tattaaacag tattttttta aagaattgga
    14281 cacaaataca atgactttta ggttaaacaa tgataaaatg caatttatag ataatgaatt
    14341 tagtaaggag gattcaaaac atggtacatt tagtatattg tgataatgca ggaaaaaaag
    14401 gagaaaaggt cttagataaa atcttggctg gaacaaaaac aatggttatt agaggtgctg
    14461 ctggtagaaa aataccacat agtagagtat ttgaagatga gttactttat tttatggaaa
    14521 aaggaactgc aaaaatatct gcaaaagcca ctgttaaaaa ggtagaaaac tatgttaaat
    14581 taacagaaga tgaaatttct aaaattttaa atgaaaatca accaaaatta aatttatctg
    14641 aaaagcaaaa agttcgttgg cataaaaaat gtttatgctt agttgaattt gaaaatgttg
    14701 aagaaataac acctcttgat tttgaccatc aaggaaatat ggatgattgg cttattgttg
    14761 aaaaaattga agatgtagtt gttggtacta gtatacctta caattatgag aagtctaaat
    14821 tttaaagtat caataacata atactatatt gctaaactct acttaaataa aaaaagagtg
    14881 catttaataa ttataaaaat tatttttata cactcttttt taataataat tttaaattac
    14941 ttactttcta atctttcata tacatctata aattcttctg ctaattgttg aaaattcata
    15001 gctgtcatta aatggtcttg tgcatgaata agtataacac ttatttcagt tttattacca
    15061 ttagcttcat tttgtatcaa ttctgtttgg aatttatgag ctttatgaat tgattctttc
    15121 gacttttcaa tacattctct agctttatct atattcccgc tctttgcttc ttttattgct
    15181 tcaaatgcta gccctttcgc atcacctgca aatccaatta ttccaaaaga tatctctatc
    15241 atcttctcat ccatttattc gacctcctaa atatctctat agcttgatat gactaatcca
    15301 ttcttttcta aaaattcttt gactttttta gatgtaagta tcttgtgctc tttcgttcta
    15361 tcaatagcat aagatgtaga atttaaaata taatcatcta aaaaagctgg gtgagacata
    15421 atatccacta catcatactt cattatttcg tctatatttt ttataaaata ttcttcactt
    15481 acattttcct tataaaaact atctattaaa ggaactactt tagaatactc taaattatat
    15541 tcaaatccac ctcttattgg aagattatac ttggttacaa tcttctctat tactggcttt
    15601 aaacttacta aagtatggat atgatggtga ctatctaaat gagatatatc tattccaagc
    15661 ccttttaccc tatctatttg agcacaaagt tctctataaa tctcatcaca atccattttt
    15721 tcaataattt cgtctgtaat cctcctaata aaaaaaccgt ctttatcaac aatagttttt
    15781 aagttagata ataatggtct accacaactt aaagtcatat gaactccaca atttaaagtt
    15841 ttattttctt taagtaagcc tactccatgt tctaccccag gcatatttgc catcatagaa
    15901 gtagacctaa ctataccatt attatgagct gaaattattc catagttcac agcttcacaa
    15961 tatccaaaat catctgcatt tattataatt ttagtcatac cataacctac tttctataga
    16021 caactatcta ttaaatctag gaagataatc tttatgagct tccaacattt cgtctaatat
    16081 agtttttgct aagtcatcag atggaatcaa tgggtttata caaagtgcca aaagagcaga
    16141 ttcataatcg ccatatacag ctgctttagc tgccaatact tcaaatgatt taatttgact
    16201 tactaatcca tgcacagaat ctggtaaata tcctatactt attggttttg gaccattttt
    16261 tgttattaca ctacttactt ctaccgcttg ttcatcttta aaatctctta tagaaccctt
    16321 atttaatgta ttaactactt ggatatcttt tttgtcgttg tatatagaac ttattaaatt
    16381 acaagcagca tcactatagt aagcccctcc tcttttttca agttgaggtg gttttacatc
    16441 taatttttca tccttatata attcaaataa ttgttcttcc aattctttaa ctacttgacc
    16501 tctagctttt ccctctttaa actctctcaa ctcatcctca agcatttctt tagttttata
    16561 gtagtatcta tgatatggac aaggtattgc acccaaagat tttacaaatt cagcattaaa
    16621 atcaattgcc tttatatttt gcatacttat atctgctttg acaaatttat caattgcttc
    16681 ttttgtaaca tcttctccat ctaaagatac atttagacca taaaccatat gattaagacc
    16741 tgcaaaatcc atacttattc tgtcactttc tacattaaat agtttggcaa catcattttt
    16801 taaatgaatt ggcacgttgc atagacctat atatcttcta aaattagtat atttgaatac
    16861 agcctctgtt attattcctg ttggatttgt aaaattcacc atccatgcat ttggacataa
    16921 ttcttccaca tcttttatta tatcaaatat aactggtatt gtgcgaaggg ctttaaataa
    16981 acctccagca ccattagttt cctgccccat aactccatga gataaaggaa tagtttcatc
    17041 ttttattctc gcatctaaaa gacctactct aagttgtgtt gtcacaaagt ctgcatctct
    17101 tagagcttct cttctatcta aagtaagatt tattttcata tctactccag ctttttttac
    17161 catcctctta gctagatttc caactatctc taatttttct tttccagctt ctatatctac
    17221 aagccataat tcctttacag gtaactcttc atatctattt ataaaaccct ctacaagctc
    17281 aggagtataa cttgaacctc ctccaattgt aactattttt agtccctttt tcatctcatt
    17341 ataccatcct tacctataat ttaatatact ctacaaaacc ccatacattt atttaaaact
    17401 ctatacattt atttaccgaa ataaaactac ctagttgtta attttcaatt tattagcttc
    17461 cattttttca gacgctatga caaatggaat atatattaat attgataata ttaaattaaa
    17521 tagtgctaaa gctccaccag tccagtcacc tgtagccatt gctccaccta atataggagg
    17581 tgttacccaa ggtattttag gtaaaattac tggtgctact aatccaaaat ctattgctaa
    17641 gtatgataca gcactacata ttactggtgc aagtacaaat ggaatcataa atataggatt
    17701 taaaactatt ggaagtccaa atatcaatgg ttctcctatg ttaaatattg caggtggacc
    17761 acctaatact atcatctctt tacgtcttct tccagctatt aataaagcta ctattaatcc
    17821 caataccatt ccagaaccac ctaaatatac aaatgcatca aagaatgcac ctgcaagtac
    17881 atggtatcct tccgttgctc ctgcttgagc caaggcagca ttttctccac ctaatttcat
    17941 aagtatagtt tctgtaaaag gaagtgctat atttgcacca tgaagtccaa cagtccaaag
    18001 tatatgaatt ataaatgcaa taagcattgt agaacctaaa ctatcagcta catttgatag
    18061 tggtgctcct aaataagtat ttaaaatatc tgttaagaaa cttccattag aaagcatttt
    18121 tataaatatt cctattacag taaatatcat tatagttaac attcctggta ttaactttgc
    18181 aaatgatctt gaaactgctg gtggaactcc atctggcatt tttatagtta atttctttac
    18241 cttagataat cttacaaata tctcagttga taataatcct attaatatag aagagaataa
    18301 agctgctgta cctaagtaag tttgttgtat cattccccat ccttcaacta ctgtagttcc
    18361 tccctcagga actattttac caatttgtgg agccattata aaaaagatag ataaagctat
    18421 aagcccagat tgtaacccat cactctcata agattttgct agaaaataag caacacctat
    18481 tactaagaat actgccattg tacctattgc tccccaccaa aggtcgcctc caaatgtggt
    18541 ccagttttct ccaaatatac ttgccatcaa gtttttgtat gcttccaatg gtaagttatt
    18601 tatcaatgtt cccaatgcac ctaccatagt tataggtatc attactataa atgcatctct
    18661 tactgctact aagtgccttt gagctcctat tttagcagct acaggcacta tatatttatc
    18721 cataaatgac atgaattttt ccattttaca tcctccagta caactttatt ttgaactatt
    18781 taactctaca gctctatcta acacagcttt tccattacat cttccataat ccatcatatt
    18841 tataacttct actggaatat tatatggttt tgccatttca gttgcttttc ctaatacata
    18901 tctaacttga ggccctaaaa gtaagacatc acaattttct atttcatttt ttaagttcac
    18961 ttctgatata gcccatattt ttgcttctat accgttttcc tttgctgcat cctccatttt
    19021 tgtaactaat aaactagttg acattcctgc tgaacaagct aacattattt ttatcatttt
    19081 ttcccctcca aattagattc attaaatatt ttttaagtca taagtttttt aaactataca
    19141 tttaaaatat gcttttctat taattttttc ttaatgtata tatcttattt ttaaatgtat
    19201 atacatttaa ttcttgatat tattatatac caaatgtata tacatttcaa gaaaactttt
    19261 tcattttatt taaattttat tcgacaacag cattcaaagt taatgtatat ccatagtgat
    19321 atgtgtgtga gtactcaaaa atctcactat tttgtaactt acaaatttgg cttatatata
    19381 aaagtggctc tggttcttct aattttagat tatccataca ttcttcattc gatattacag
    19441 cttgtacttc tctctctgac atggctatct tgtatccaca cacttcttca acaaaattat
    19501 aaagagaatt ttcacaatga gtcttattta aatttggaaa taacttaact ggcatataag
    19561 taatcatata tgaaactctt gcatcattag ctaatcttac tctttttatt tcccaaacat
    19621 tttcttctaa acttatattc aacttacttg ataaattttc atctgcctga actatttcaa
    19681 gagataccaa tatattagat actttatagc ctttactttc catctcttta gtaaatccac
    19741 ttacagacga tatattatca tatatattat ttgcaataac tatactacct acacctcttt
    19801 gtctagttat atagccttct ttaactagat tattaagtgc agaccttaca gtcattctag
    19861 ttacattaaa ttcttcactc agctgttttt cagaagggat taaatcccct tctttcaaac
    19921 tgtctgaatt tattaactct ctaacatgat tttctataac tttataaatt ggctctttca
    19981 tttaattcac tccttattaa atcttttata taataagata attttatata caaacaaaga
    20041 aaatgtctat acatttaaga taatttaaat tttattcaga aatcttgtac aactttccga
    20101 gttttaataa agatataaat agacttatca ttaatatacc ttttaatata cttgataagg
    20161 ttatactcca ccatacacca tttagaccca acatttctgg tctagatata aagtaagcca
    20221 atggtactct tgcaccagtc agtatagtaa ttataataga aggtatatag gttctcccta
    20281 atcctttgaa agctcctgtt gttattattt ctaaacacat aaaaaattga gaatagccta
    20341 atattttaag ataaactgct cctttttcta ttgcctcact ttcatctata aaaatagaaa
    20401 atatactctc tcctgcaaac actaatacta aagtagttat tataccaagt acagaagata
    20461 cagttatagc tattttgcaa cctttattta ttctagaata cttcttggca ccataatttt
    20521 gtccaacaaa actgcctaat gcaactgata gcccttcagc cgtcatccag gaaattgctt
    20581 ctatttgtga gcctactttt tgtactgcaa cagccacagg cccccatgat gctactatta
    20641 ctcctaatag cattgagaat actgtaaaca taccactttg tattgctata ggtaatccca
    20701 atttatacag aactttataa tatttagtct ctatttcttt aaatagtctt aatttaaaat
    20761 attcttcttt acttttaact attatatata taaaacatgt agtaactact atctgagcaa
    20821 atacagttgc aatagcagct cctgcaacac caagttttgg agcaaatccc catccaaaaa
    20881 ttaatatagg gtcaagtata atattagtta ttaatcctac tgtattaata cgaaaaggag
    20941 ttttactatt tccaagacca ttgaaaattg cagtaaatac tggattaata aaataaaata
    21001 ccatacctag agctactatt atcaaatact gtctagacat ggttataact tctaagtctc
    21061 ctaatctaaa aaaacctatc aattgtttat taagtactat taaagaaatt gtatatatta
    21121 ttgctagtat aatatttatt tctattgctg acttcatata tgatttagta gtgcttatat
    21181 tatttgcacc aatactttgt gctactttta tctctccacc tacttttgaa atcataataa
    21241 atgccattgc aagccatgga aaaaaaccag ctgttccaac tgcagctact gctttacttc
    21301 cggctttacc aacccatatc atatctatca tgttataccc catctgtata aatgaagtcc
    21361 ccattattgg aagtgatagc ttaagtaatt tttctgtaat tcttccttct gttaaattaa
    21421 gtctgtcttt cattttccac ctcttttata ttaaatttat ttgcttatat agctagatta
    21481 atcattttat ttgattgagt tcactatcct tcaatttata ttatcatatc tcaggattgc
    21541 atctcaatca tacttatgtt taagatacag tattttacct atctatgata aaattaatac
    21601 ttatgaatat aaatctagcc atttcatcaa tacatattct aacctttaac ttaacttcaa
    21661 ttaagtatac atatcgtaac caattagaat attttatacg gtatcttcca ttaataaaca
    21721 accaatatca atgatttata tataat
//
LOCUS       DAEQCW010000063        21221 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.063, whole genome shotgun sequence.
ACCESSION   DAEQCW010000063 DAEQCW010000000
VERSION     DAEQCW010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21221)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21221)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21221
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.063"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            304..1728
                     /locus_tag="KRO40_002317"
     CDS             304..1728
                     /locus_tag="KRO40_002317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol transporter subunit IICB"
                     /protein_id="HBH2093134.1"
                     /translation="MSSSNQSTIKTSIQRVGKFLSGMVMPNIGAFIAWGLITALFIPT
                     GWMPNEKLSTIGDPMIKYLLPLLIAYTGGKAIAGQRGGVIGAAAAMGVIVGADIPMFI
                     GAMIMGPFAGWVIKKFDKFVDGKIPTGFEMLVNNFSIGIIGMLLAILGFYAIGPAIVA
                     GTALIESGVQFIVSKSLLPLVSVFIEPGKVLFLNNAINHGILGPIGIAEAKEAGKSIM
                     FLLESNPGPGLGVLLAYWMFSRGSVKQSAPGAVIIHFFGGIHEIYFPYILMNPVLILA
                     TMAGGAAGILTFSILGAGLVAAPSPGSIFALMALAPKGGLLPVLAGVAVATVVSFLVA
                     APFVKRASANQSEEDSTSLEEAKAKMSDMKSASKNSEKNIEEKQLEVNEIKKIVFACD
                     AGMGSSAMGASRFKNRIKNLDLNIEITNSSVDNLPDDTQIVVTHNTLVERVAKNNSSV
                     EIVSINNFLNDPNLDTLFKRLESK"
     gene            1763..3892
                     /locus_tag="KRO40_002318"
     CDS             1763..3892
                     /locus_tag="KRO40_002318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH2093135.1"
                     /translation="MKKKKITSRQKKIILMIVENSKKNIPITISEIAGTLELSSRTVL
                     RDMSGIEKWFDENDFNFVKKPGVGLILEENIENQNFIIELLEEEKIEKEYSKEERNLI
                     ILSKLLVSNEPVKSYYFAKILKVSEGVLNNDFALASKWLERFDIELVRKPGLGVYLKG
                     QEKSFREAYVNLIYDSFNEKEILDMVRNISENIQTDKAIEILSENRLLNLMDRCIIRK
                     VEATLTKKLSDLDVNLADSAYIGLVVHISLALQRIKNGENITMDKEFLKELSITEEFK
                     LAKEIVKGMETDFNMDIPVDEVGYITMHIRGAKQRSSSNHKALNLDDIEIMEITNKMI
                     DLAEDEFKISLKNDERLFKDLANHLGPSINRLNMGLEIRNPLLDEIKSKYSYAYDGVE
                     KISRIIKDKLNINSIPESEIGYIAMHFASAIEKNLMMNTNINIVVACPTGIGTSRFLS
                     TKIENKFPNLNILETISAINIDEEYLKEKDVDLIVSTVELNTSLNYICVGPFMSLDDE
                     QIIKEKIKSIAQNKLINLNAKNDTKSKNKVYEQITESMNIGKDILQFLEEIRFEKFES
                     KDLSELIEDSSKIFAKSSEDIISIKESLKERLKISIPYIEESKILLLHCMSERIDIMK
                     LSIIKLENRIVLDSNEEIDNVVFMLLPKNSPSYQRQIMSEISGSLIDNIIFTNKINKF
                     SIEEMALEVKDIVFNFYTNRLKAFIDK"
     gene            3922..4344
                     /locus_tag="KRO40_002319"
     CDS             3922..4344
                     /locus_tag="KRO40_002319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093136.1"
                     /translation="MSKVLNENNIFLGLDSVSKEEAITLAGRKLVENGYVKEEYIPAM
                     LEREKVMTTYMGMGVAIPHGVNEAKKEILSSGIVILQFPNGIDFDGEKAYLLIGIAGV
                     GDEHLEILSNIAVVLDDDLTERLKNSNDKQAFMEAFAN"
     gene            4363..5514
                     /locus_tag="KRO40_002320"
     CDS             4363..5514
                     /locus_tag="KRO40_002320"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH2093137.1"
                     /translation="MKKAIQFGAGNIGRGFIGGLLVKSGYHVVFADVNEGILNSINKD
                     KKYTIHIRDVECIDEVIDNISAVSSIKEEIIDEIVQAEIITTAVGPLVLTKIASTIAK
                     GIKARKEKGLTSNLNIIACENAIYASSSLKEEVLKYLNKEEVEYLEMYVGFPNCSVDR
                     IVPPGKNENPLDVTVENFYEWNVEKQGFKGEIPTIVGMNLADNLMAYIERKLFTLNTG
                     HAITAYIGYLKGYKTIEESIKDKFICDIVKSAMVESGEGLIKKYNFDSEVHYKYIDKI
                     LNRFKNPYLNDDVLRVGREPLRKLSDKDRLIKPLMTAKSYGLSVDNLILGIGAALHYN
                     NSEDTQSVELQELIKSIGVKKAVAKIANISNDEELLNNIEKSYIFMKNL"
     regulatory      5620..5721
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            5904..6476
                     /locus_tag="KRO40_002321"
     CDS             5904..6476
                     /locus_tag="KRO40_002321"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HBH2093138.1"
                     /translation="MKALQEKILREGSVSGNDILKVDSFLNHQIDVAFLNEIGREFKE
                     RFKGEKVDKIFTIEASGIAIASIVSQYFDNAPVVFAKKSESKNLDKDVYETNVYSFTK
                     AREYSVKVSKKYINKGENILIVDDFLANGRAALGLKDLIEQAEANLVGVGIVIEKGFQ
                     AGGALLKANDVRLESLAVVESIDNGTVKFR"
     gene            6540..7190
                     /gene="fsa"
                     /locus_tag="KRO40_002322"
     CDS             6540..7190
                     /gene="fsa"
                     /locus_tag="KRO40_002322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBH2093139.1"
                     /translation="MRFFIDTANIEEIKEANDLGVICGVTTNPSLIAKEGRDFIEVVK
                     EISEIVDGPISAEVISLEHKGMIEEAEKLSKIHKNIVIKIPMTAEGLKAVKVLSSKGI
                     KTNVTLIFSAGQALLAARAGATYVSPFVGRLDDISQNGLDLIEEIVDIFSVNSIEAQI
                     IVASVRNPIHVLQAARMGADIATVPLKVINQMIKHPLTDKGIDSFMKDWEGASLKL"
     gene            7342..10266
                     /locus_tag="KRO40_002323"
     CDS             7342..10266
                     /locus_tag="KRO40_002323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093140.1"
                     /translation="MDKILREIQREDKKNPYTDQELAEMLNVARSEVISVRKKNNILD
                     SRERRKKILIKDISKIVSENPQMSERKITEILIENGYNISRSAVSKLLKEENLNQSKI
                     GIKDKDPASSGKYVKVSKVVEEDGFEELIGIKGSLKEKVNLAKSAIMYPPNGLHTIIY
                     GETGVGKSELATCMYKYAIKNNIKEENSPFIVFNCADYAENPNLLIAQLFGVVKGAYT
                     GADANREGLVEQANNGILFLDEIHRLPAAGQEILFSLIDRGEFRRLGESSSNRKANVL
                     IISATTENPDSNLLQTFRRRIPMVINLPNMSERPKSERYEIIIKFFEREAKRVNKNFI
                     ITKEVMCALMNYKCTGNIGQLKSDIQVTCARAFSKSIFSSDKVIIDLDSLRDYIKSGY
                     YDCNCKNEKYSEFSVEDIYIDISELVSGKNRILSDNEISEIYNYAEKELKVLESKCFS
                     EEELKNAFIEKLDKKFNAIKNNKNLSDRRSRIDWGGQLKESTLEIMDKVIVFIKEQFK
                     HVNQGLYLALAIHIEHAIGRIKDGKTIINPSLDKIKASMPMEYELSRYIMGIVEDLTQ
                     VTFPEDELGYLAYYINKFCYNEESIKDKVKVVIVTHGKVGIEMSKVVNHILGIECTLG
                     IEIALTDSPSEGIEHVLEELQKIEARKGILVLIDMGSLVILGDEVEKRLGIRCKTVNR
                     VDTLLAMEAGKLATIEGKSLDGIIADLKKNKNYAMINTNKFSYRKNEYGKKNVIITLC
                     LSGVGTALNLKEHIEKQIKEYDTLIEVKPVAFLNNNLEEELNDIEAEYNIIAICGTID
                     IDYKNVPFISYNEVLGKNGINKVLEHLNSKQPALNIENQLNNLIHEDLILYNFEGISK
                     EYIIDTLVSKLEEGGYVDSKYILSVYKREAMGSVVMASKVAVPHGLPENVIKPAIAIA
                     RLNKPIVWDNKFMVDLVVLLALKENNKKEIRSLFSKINDQHTLEVLLNTEDKNEIKEL
                     LS"
     gene            10858..11316
                     /locus_tag="KRO40_002324"
     CDS             10858..11316
                     /locus_tag="KRO40_002324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093141.1"
                     /translation="MEFINFVSDKVIDLKMDCKTKEDFFKEIHNKVFDLGFVKEEFGE
                     KILARENVFPTGLNLGDYGVAIPHTDAEYIKEQFISVCTFNEPVVFSSMEDQDEKVPV
                     NLAFVLGLNQPHSQLSVLTELMGIMQNKELVDKLMSSTDKEEVLKTLKSL"
     gene            11377..11652
                     /locus_tag="KRO40_002325"
     CDS             11377..11652
                     /locus_tag="KRO40_002325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBH2093142.1"
                     /translation="MKKILVACGAGIATSTVVCDKVERLVKENNIQAEVIQCKIAECA
                     TKQEGADLIVSTTILPTTYNIPAIKATAYITGVNTAALDKKILDALK"
     gene            11711..12985
                     /locus_tag="KRO40_002326"
     CDS             11711..12985
                     /locus_tag="KRO40_002326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012951111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBH2093143.1"
                     /translation="MDKLLAVVQYILNMGPTVILPITIVVLGMIFRIKFTKALKSGLT
                     IGIGFVGINLVVNLLTSTLGPAAQGMVERFGLNLTVIDVGWPTTASATWASPVAPILI
                     PVCLLVNLLLLYFNKTKILNVDIWNYWHFIVAGAVGYIVTGSYVWAIFCAILMELLVL
                     FIAEKTAKNVQEFYDLEGIALPTGSTASFAPLGYLVGKFVEKIPGINKIQADPDSIQK
                     RFGIFGEPMMMGIILGIILGALAGYDVAGIFNVGISMGAVMLLMPRMVRILMEGLIPI
                     SESIRDFLQAKYGDRELYIGLDAAVATGHPAVISTALILVPITLFLAVILPGNKVLPF
                     GDLATIPFYMAFIVCFRKGNIVQSVITGTIVIAISLYMATNFADVHTQLLQQANMMPE
                     GTTMVTSIDTGGNLLKWGILKLSQLVSSFGIF"
     gene            13115..14167
                     /locus_tag="KRO40_002327"
     CDS             13115..14167
                     /locus_tag="KRO40_002327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBH2093144.1"
                     /translation="MKAAVLHGTNDMRFEDIEIKPCESDEVKIKVMAAGICGSDPPRV
                     LKHWKYPVPAIPGHEFSGVIAEVGKDVKNVKVGDRVVAIPFIPCNECEYCKRGLFSLC
                     DDHGMLGAKSFGAFAEYVNIKATNVLPIGDMDFEDAAMIEPLAVAMHGVLNIGVQVGD
                     TVAVMGSGTMGQLVIQGLKIAGAGTIIAVDISDNKLRESKELGADIIINAKDINPVEK
                     IKELTGGKGVDIALECAGSKITQEQCLLITKKKSKIGFLGIAYSDITLSEEAFENIFR
                     KELELKGFWNSYSAPFPGQEWTKGINLVNEGKIKLKEMVSHRFSLEDTYKAFEMIRDR
                     KEEFNKILILPQGVEK"
     gene            14167..15198
                     /locus_tag="KRO40_002328"
     CDS             14167..15198
                     /locus_tag="KRO40_002328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012986518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
                     /protein_id="HBH2093145.1"
                     /translation="MKAVVKTKPGYDNVEVLEVEEPKATGDKVKIKVEYSGICGSDIH
                     SFKGEYANIKAPVTLGHEFSGIVVEVGEDVKNIKVGDRVTSETTFATCEKCIYCETKD
                     YNLCPTRKGIGTQVNGSFAEYVLSREESIHVLPENVSLLSAALTEPLACCVHAALEKT
                     TIESSDTVLIIGPGPIGLLLAQVVKSQGATVIMSGVTKDKERLEIAKNLGVDRTVNVM
                     EESLADVVNEMTDGNGVNKGFDCSGFMPAVNEALRLLRKKGTFVQVGIFAKKLNEMDQ
                     EAIIQRELQYIGSRSQKPSSWITALDLMASGKVNTEALVTRTVGLDEFKEGITALMNG
                     EEIKVAVKS"
     gene            15290..16102
                     /locus_tag="KRO40_002329"
     CDS             15290..16102
                     /locus_tag="KRO40_002329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBH2093146.1"
                     /translation="MSTLRDHSNNIRKNIIKMVAEAKSGHPGGSLSIADMLTVLYFDK
                     MNVCAENPKMADRDRFVLSKGHAAPALYATLAEKGFFPEEELITLRKFGSKLQGHPDM
                     KKVAGIDMSTGSLGQGLSAANGMALAGKLDNKDYTVYTILGDGEIQEGQIWEAAMTAS
                     HYKLDNLIAFVDLNGLQIDGSNEEVMNVNPVDDKFKSFGWNVIVINGHSFEEIGNAVD
                     EAKKVTGKPTVIIAKTVKGKGVSFMENNAAWHGTAPNAEQAEQALKDLEGGL"
     gene            16105..17025
                     /locus_tag="KRO40_002330"
     CDS             16105..17025
                     /locus_tag="KRO40_002330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBH2093147.1"
                     /translation="MGIATREAYGQVLKELAENKDIVVLDADLGKATKSISFKEVAPD
                     RFFDMGIAEGDMIGTAAGLATCGKIPFASTFAIFAAGRGYEQIRNSVAYPNLNVKIAA
                     THAGVTVGEDGGSHQAIEDISLMRGIPNMVVLNPADALEARQAILASIDYNGPVYIRL
                     GRAATPDVNSENYKFEIGKGTVLREGSDITVIATGIMVAKALEAAEELAKEGINVEVV
                     NISTIKPLDEALIKETAKKTGKVVTAEEHSIIGGLGSAVCEALAETKDVVVRRIGVKD
                     VFGQSGTPADLLKHYGLTTEDIVKNIKELL"
     gene            17200..17646
                     /gene="rpiB"
                     /locus_tag="KRO40_002331"
     CDS             17200..17646
                     /gene="rpiB"
                     /locus_tag="KRO40_002331"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBH2093148.1"
                     /translation="MKISIGCDHGGYELKEYIKENLINKGIEVEDVGTNSKESVDFPI
                     YAKKVSQNVQSKKSDLGILCCGTGIGMSIAANKFKGIRAAVVSDCFSAKATREHNNTN
                     VLCLGERVIGKGLAMRIVEEWLNSSYNGERHARRLQMIDDIEKENL"
     gene            17676..18341
                     /locus_tag="KRO40_002332"
     CDS             17676..18341
                     /locus_tag="KRO40_002332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBH2093149.1"
                     /translation="MSIICASIMCADQMKLKEELEALEEAGVKLLHCDVMDGIFVKNL
                     AMGPELLKSISENTTIPLDIHLATETPDKYIDMMSYIKPKYISFHVESSTNVKADIQK
                     LRNYGIGPVLAISPQTSVDKIEEYISLVEGILVMTVNPGFAGQKFNLSVLDKLDKLTE
                     ILKDYDNPPFIEVDGNINKDTIKLMNGKKVDIYVVGTSALFNDKPPISYKDKIEELKE
                     SIK"
     gene            18451..19953
                     /locus_tag="KRO40_002333"
     CDS             18451..19953
                     /locus_tag="KRO40_002333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase/phosphoglucomutase"
                     /protein_id="HBH2093150.1"
                     /translation="MGDLYKLQNGTDIRGIAYENDSKEVNLTVEEVKKIAKAFHIWLK
                     EKTKKDKVTVAIGTDSRITGSQFRSTVIETLTNDDCNVIDCEIATTPAMFMTTIMDGY
                     NSDGAIMITASHLPYYYNGLKFFTESGGLEKTDIKEMLDIAVKNDSVDYEEVNKKGEV
                     IVKNLIEDYSNLLIDKIRKGVNSSKNYEKPFSGLKILVDAGNGAGGFFAEKVLHILGA
                     DTTGSQFLNPDGMFPNHIPNPENKEAMESICKAVLDNKSDLGIIFDTDVDRAAIVGKN
                     GKPINKNALIAVISSIVLEEHPKTAIVTDSITSEGLAKFINELQGRHHRFKRGYKNVI
                     NEAIRLNSEGEECHLAIETSGHAALKENYFLDDGAYLIAKILIKVAKLSLEGKTIEEL
                     IENLEEAQEEKEVRIGINKEDFRPYAEDILKDLDSHVKSIDGWSVAPNNFEGIRVNCD
                     ESNGDGWFLLRISLHEPLLALNIESNKIGGAEQIYSKLKLFLEKYDLKGL"
     gene            complement(20265..>21221)
                     /locus_tag="KRO40_002334"
     CDS             complement(20265..>21221)
                     /locus_tag="KRO40_002334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2093151.1"
                     /translation="LVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIYNFLSVKFNYIN
                     NISKNIKNIENGNLKYKLKVIGDDEISTLAKSINNITGGLETAVDANIKNERMKAELI
                     TNVSHDLKTPLTSILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKL
                     SSGDVEFNITKTDIRELLIQSIVEFEDKIQNSSLDFIIETPEYAVFTMIDGKKTWRVF
                     ENLICNILKYSMPNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGDISR
                     KTDGSGLGLSIAQNIIELENAHMEIIIDADLFKVMLTFRRVN"
BASE COUNT         8589 a         2225 c         3929 g         6478 t
ORIGIN      
        1 agataaatta aatctatatt agtatatcca aaagtacatt taataaattt atttaactga
       61 attattattt tcatttctat taaatttaaa tattttataa aaatagtatt atttacaaaa
      121 tcatatactc caaaatacta cataaataaa attaaacaaa aactaaaatg acaaatgtca
      181 ttatctaaag tgacatagaa acggtttctt aaagttgtta ctataaaata taaactctat
      241 aataaaagta taacaaaagg gaatcatatc gatatagaat ataattcaag aggaggtaaa
      301 attatgagta gttctaatca atcgacaata aagacatcta tacagcgagt agggaaattt
      361 ttaagtggta tggtaatgcc aaatatagga gcttttatag catggggtct tataacagca
      421 ttatttatac caacaggatg gatgcctaat gaaaaattga gtactatagg tgacccaatg
      481 ataaaatacc ttttaccact attgatagct tatactggtg gtaaagcaat agcaggacaa
      541 agaggtggcg taataggtgc agcagcagct atgggagtaa ttgttggtgc agatatacca
      601 atgtttatcg gagcaatgat aatgggacca tttgcaggat gggtaattaa gaagtttgat
      661 aaatttgtag atggaaagat accaacagga tttgaaatgt tagtaaataa cttttcaata
      721 ggtataatag gtatgcttct tgcaatacta ggattttatg caattggacc agcaatagta
      781 gcaggaacag ctcttataga atctggagtt caatttatag ttagcaaaag tttattgcct
      841 ctagtttcag tatttataga acctggaaaa gtattattct taaacaatgc aataaatcat
      901 ggtatattag ggcctatagg tatagctgag gcaaaagaag caggtaaatc tataatgttc
      961 ttactagaaa gtaaccctgg accaggttta ggagttctat tagcatattg gatgtttagt
     1021 agaggaagtg taaaacaatc agcaccagga gctgtaataa tacatttctt tggtggtatc
     1081 catgaaattt acttcccata tattttaatg aatccagttt taatattagc tacaatggca
     1141 ggtggagcag caggaatatt gactttttca atattaggag ctgggcttgt agcagcacca
     1201 tcaccaggaa gtatatttgc acttatggca ctagctccaa agggaggatt acttccagta
     1261 ttagcaggag ttgcagtggc aacagttgta tcattcttag tggcagcacc atttgttaag
     1321 agagcttcag caaatcaaag tgaagaagac agtacttctt tagaagaagc taaagcaaaa
     1381 atgagtgata tgaaatctgc aagtaagaac tctgagaaaa atattgagga aaaacagctt
     1441 gaagtaaatg agattaagaa gattgtattt gcatgtgatg caggaatggg ttcgagtgca
     1501 atgggagctt ccagatttaa aaatagaata aaaaacttag acttaaatat agaaattaca
     1561 aattcatctg ttgataatct tccagatgat acacaaatag tagtaactca caatacatta
     1621 gttgaaagag ttgctaagaa taattcaagt gttgagatag tttcaataaa caatttttta
     1681 aatgacccaa atttagatac attgtttaaa agattagaat ctaaataaaa ataaaaagta
     1741 ccactaatta ggagtggata atttgaaaaa aaagaagatt acatctaggc aaaaaaagat
     1801 aatactaatg atagtagaaa attcaaagaa aaacattcca ataactattt ctgagattgc
     1861 agggacttta gagttaagtt caagaactgt acttagagat atgtctggaa ttgaaaaatg
     1921 gtttgatgaa aatgatttta actttgtaaa aaaaccagga gtgggattga ttttagagga
     1981 aaatatagaa aatcaaaact ttataattga gttgttagaa gaagaaaaaa tagaaaaaga
     2041 atacagcaag gaagaaagaa atttaattat attatcaaag ctactagttt ctaacgagcc
     2101 agtaaaatcc tattattttg caaaaatatt aaaggtatct gaaggggtac tgaataatga
     2161 ttttgcctta gcaagtaaat ggttggaaag atttgatatt gagcttgtta gaaaaccagg
     2221 gcttggtgtc tatttaaaag gtcaagaaaa aagctttaga gaggcatatg taaatcttat
     2281 atacgattca ttcaatgaaa aagaaatact agatatggtc agaaatataa gtgaaaatat
     2341 acaaacagat aaagcaatag aaattttaag tgaaaataga cttttaaatt taatggacag
     2401 gtgcataata agaaaggttg aagctacatt aacaaagaag ctttcagatt tagatgtaaa
     2461 tttagctgat agtgcatata tagggcttgt agttcatatt tcattagcct tacagaggat
     2521 aaaaaatggt gaaaatataa ctatggataa agagtttcta aaagaattat ctataacaga
     2581 agagtttaaa ttagctaaag aaatcgtaaa aggtatggaa acagatttta acatggatat
     2641 accagtagat gaggttggat atataactat gcatataaga ggtgcaaagc aaaggtcatc
     2701 ttcaaaccat aaggctttaa acttagatga tatagaaata atggaaatta caaataagat
     2761 gatagatttg gcggaagatg aatttaaaat aagtttaaaa aatgacgaga ggttatttaa
     2821 agacctagca aatcacttag ggccttctat aaatagattg aatatgggat tagaaataag
     2881 aaatcctctt ttagatgaaa taaaaagcaa gtattcatat gcctatgatg gagttgaaaa
     2941 gatttctaga attataaaag ataaactaaa tataaattca atacctgaat cagaaatagg
     3001 atatattgca atgcactttg catcagccat agaaaaaaat cttatgatga atactaatat
     3061 aaatattgtt gtggcatgtc ccactggaat aggtacttca agattcttat caactaagat
     3121 tgaaaataaa tttcctaatt taaatatact tgaaaccata tcagctataa acatagatga
     3181 agagtattta aaggaaaaag atgttgattt aatagtgtct acagttgagt taaatacaag
     3241 tttaaattat atatgtgtag gtccatttat gagtttagat gatgaacaga taatcaagga
     3301 aaaaataaaa tctatagctc aaaataaatt aatcaattta aatgcgaaaa atgatactaa
     3361 gagtaagaat aaagtatatg aacagataac agaaagtatg aatataggaa aagatattct
     3421 tcaattttta gaggaaatta gatttgaaaa atttgaaagt aaagatttaa gtgagcttat
     3481 tgaagactca tcaaaaatat ttgcaaaatc tagtgaagat ataatctcta taaaagaatc
     3541 gttaaaagaa agattaaaaa tttcaattcc atatatagaa gaatcaaaaa ttctattgtt
     3601 acattgtatg agtgaaagaa tagatattat gaagttatca ataataaaac tagagaatag
     3661 aatcgtgcta gattcaaatg aagaaatcga caatgtagtt tttatgttac ttcctaaaaa
     3721 ttcaccaagt tatcaaagac aaataatgag tgaaataagt ggttcattaa tagacaatat
     3781 aatttttact aataagataa ataaattctc tatagaagag atggcattag aggtaaaaga
     3841 tatagttttt aatttttata caaacagatt aaaagcattt atagataaat aaaattaata
     3901 ttaaaaagga aggttgatac tatgagtaaa gtattgaatg agaataatat atttttagga
     3961 ttagatagtg tttcaaagga agaagctata actttagcag gaagaaaatt agttgaaaat
     4021 ggatatgtaa aagaagaata tataccagca atgttagaaa gagaaaaagt aatgactaca
     4081 tatatgggaa tgggagttgc tattccacat ggtgtaaatg aagcaaaaaa agaaatatta
     4141 tcttctggaa tagttatatt acaattccct aatggtatag attttgatgg agaaaaagca
     4201 tatttattaa taggaatagc tggtgttgga gatgaacatt tagaaatact atctaatata
     4261 gcagtagttt tagatgatga cttaacagaa agactaaaaa attcaaatga caaacaagct
     4321 tttatggaag cttttgccaa ctaatcttag gagggattta aaatgaaaaa ggcaattcag
     4381 tttggagcag gaaatattgg aagaggtttt attggaggct tgttagttaa gtcgggttat
     4441 catgtagtat ttgctgatgt aaatgagggg atattaaact caataaacaa agataaaaag
     4501 tatactatac acataagaga tgtagaatgt atagatgaag taattgataa tataagtgcg
     4561 gtttcatcta taaaagaaga aataatagat gagattgtac aggctgaaat aataactaca
     4621 gcagttggac ctttagtttt gactaaaata gcctctacaa ttgcaaaagg tataaaggct
     4681 agaaaagaaa agggattaac aagtaatcta aatataatag catgtgaaaa tgcaatatac
     4741 gcaagttctt ctttaaaaga agaggtactt aagtatttaa ataaggaaga agtagaatat
     4801 ttagagatgt atgttggttt tccaaactgt tcagttgata gaatagttcc tcctggtaaa
     4861 aacgaaaatc ctcttgatgt aacagttgaa aatttttatg agtggaatgt tgaaaaacaa
     4921 ggatttaaag gggaaatacc aactatagtt ggaatgaatt tagctgataa tcttatggct
     4981 tatatagaac gtaaattgtt tacactgaat acaggtcatg ctataacagc ttatatagga
     5041 tatttaaaag gatataagac tatagaagag agtataaaag ataaatttat ctgtgatata
     5101 gtcaaaagtg caatggtaga aagtggagaa ggattgatta aaaaatacaa ttttgactca
     5161 gaagtgcact ataaatatat tgataaaatt ttaaatagat ttaaaaatcc atatcttaat
     5221 gatgatgtat taagagtcgg aagggaacca ttaagaaaac taagtgataa agatagattg
     5281 attaaacctt taatgacagc aaaatcatat ggattatcag ttgataattt gattcttgga
     5341 ataggtgcag cgcttcatta taataatagt gaagatactc aaagtgtaga attacaagag
     5401 ttgataaagt ctattggggt aaaaaaagcc gttgctaaaa tagctaatat aagcaatgac
     5461 gaagaacttt taaataatat cgaaaaaagt tatatattta tgaaaaattt ataaatttac
     5521 ttgaaaaaaa gtagttctga taaagtaact ataatatatt attctacaca gtttgaatta
     5581 tttgttgaat aatagagaat tataatatat aattaaaagg aataaattaa tatatttacc
     5641 tgtatatgtt tgataatatg gttcaaatgt ttctactaag ctaccattaa tagcttgact
     5701 acaggagtga agaagatata gtttatactt attttaaatt atatattaag ttaattactt
     5761 tgaattttaa gctcctgtct atgatataga caggagcttt tttagtattt taatataaaa
     5821 tacttacaag aatagatagc aaaattagaa caaatataat ttttttatta atataatttt
     5881 agaaagggct aggtggaagt tcaatgaagg ctttacaaga aaagatattg agagaaggta
     5941 gtgtttcagg aaatgatata ctaaaagttg atagtttttt aaaccatcaa attgatgtag
     6001 cttttttaaa tgaaatagga agagaattta aagagagatt taaaggagaa aaggtggata
     6061 agatatttac aatagaggct tcaggaatag ctatagcatc aattgtttca cagtattttg
     6121 ataatgcacc tgtagtattt gcaaaaaaat cagaatctaa aaatttggat aaagatgtat
     6181 atgaaactaa tgtatattca tttactaagg caagagagta ttcagttaaa gtttctaaaa
     6241 agtacataaa caaaggcgaa aatatattga tagtggatga ttttttggca aatggaagag
     6301 ctgctcttgg acttaaagat ttaattgagc aagcagaagc taacttagtt ggagtaggaa
     6361 ttgtcattga aaaaggattt caagctggag gagcactttt aaaggctaat gatgtaagat
     6421 tagagtcttt ggcagtagtt gaatctatag ataatggaac tgtaaaattt aggtaattta
     6481 tgatattata tatttgtgtt tagcacatat tttaactatg taattatgga ggatttttta
     6541 tgagattttt tatagacaca gccaatattg aagaaataaa agaagcaaat gatttaggtg
     6601 taatctgtgg tgtaactact aatccgtctc taatagctaa agaaggtaga gattttatag
     6661 aggtagttaa agaaataagt gaaatagtag atggaccaat aagtgcagaa gtaataagtt
     6721 tagaacataa aggtatgata gaggaagcag aaaaattatc taagatacat aaaaatatag
     6781 ttataaagat acctatgaca gcagaaggtc taaaagcggt gaaagtacta tcaagtaaag
     6841 gtataaagac taatgtaacg cttatattct ctgctggaca agctctttta gctgctagag
     6901 ctggagctac atatgtaagt ccttttgttg gtagattgga tgatatatca caaaatggtc
     6961 ttgatttaat tgaagaaatc gttgatatat ttagtgtaaa tagtattgag gctcaaataa
     7021 tagttgctag tgttagaaat ccaatacatg ttttacaagc tgctagaatg ggagcagata
     7081 tagcaacagt tcctcttaaa gttataaacc aaatgattaa gcatcctttg acagacaaag
     7141 gaatagatag ctttatgaag gattgggaag gtgcttcttt aaaattataa ttataaacta
     7201 cgctttataa gtatattaaa gaggttatta tggaaattct aagtaataag gctaggctat
     7261 tttgcctagt cttattttgg tgtataatat attgaaacat attattgaaa tagattaatt
     7321 ttttaagtga ggaggcgaaa aatggataaa atattaagag agatacaaag agaagataaa
     7381 aaaaatccat atactgacca agaacttgct gaaatgttaa atgtagctag gtctgaagtg
     7441 atatcagtta ggaaaaaaaa taatatttta gattcgagag aaagaagaaa aaaaatatta
     7501 ataaaagata tatcaaaaat tgtaagtgaa aatcctcaaa tgtctgaaag aaaaataact
     7561 gaaatattaa tagaaaatgg atataatata tcgagaagtg cagtttcaaa attattaaaa
     7621 gaggaaaatt taaatcagtc aaagattggg attaaggata aagacccagc atcatcagga
     7681 aagtatgtga aggtgagtaa agttgtagaa gaagatggat ttgaagaatt gataggtata
     7741 aagggaagtt tgaaagaaaa ggtaaattta gctaagtcag caataatgta tcctcctaat
     7801 ggccttcata ctataatata tggagaaaca ggagtaggta aaagtgaatt agctacatgt
     7861 atgtataaat atgctataaa aaacaacatt aaagaagaga acagcccatt tatagtgttt
     7921 aactgtgcag actatgcaga aaatcctaat ctattgatag ctcaactctt tggggtagta
     7981 aaaggtgcat atacaggagc agatgcaaat agagaaggtc ttgtagaaca agctaataat
     8041 ggaatattgt ttttagatga aattcataga ttgcctgctg ctgggcaaga aatcttattt
     8101 tcattaatag atagaggaga atttagaagg ttaggagaaa gtagttctaa tagaaaggca
     8161 aatgttctca taataagtgc tacaacagaa aatccagatt ctaatttact tcaaacattt
     8221 agaagacgta taccaatggt aataaattta cctaatatga gtgaaagacc aaaatctgaa
     8281 agatatgaaa taataataaa gttttttgaa agagaagcaa agcgagtaaa caagaatttt
     8341 ataataacta aagaagttat gtgtgcactt atgaattata agtgtactgg aaatataggt
     8401 cagttaaaga gtgatataca agtaacttgt gctagagctt ttagtaaatc gatattttct
     8461 agtgataaag taattataga tttagatagt ttaagggatt atataaaaag tggatattat
     8521 gattgtaatt gtaaaaatga aaagtattct gagttttcag ttgaggatat atatatagat
     8581 attagtgaat tggtgagtgg aaaaaataga attttatctg ataatgagat aagcgagata
     8641 tataattatg cagaaaaaga gcttaaggtt ttggaaagta agtgcttttc agaagaagag
     8701 ttaaaaaatg catttataga aaagttagat aagaagttta atgctattaa aaacaataaa
     8761 aatttatctg atagaagaag tcgaatagac tggggaggac aattaaaaga gtctacactg
     8821 gagataatgg ataaggtaat tgtatttatt aaggagcagt ttaagcatgt aaatcaaggg
     8881 ctgtacttgg ctctagcaat tcatattgag catgctatag gtaggataaa agatggaaaa
     8941 actataataa atccgagttt agataaaata aaagcatcaa tgccaatgga atatgagttg
     9001 tcaagatata taatgggtat agtagaagat ttgacacaag taacatttcc agaagatgag
     9061 cttggatatt tggcttatta tataaataaa ttttgttata atgaggaaag tataaaagat
     9121 aaagttaaag tagtaatagt tacgcatggt aaagttggaa ttgaaatgtc taaagttgta
     9181 aatcatattt taggtataga atgtacacta ggtatagaaa tagcacttac agattcacca
     9241 tcagagggga tagagcatgt attagaagag cttcaaaaga tagaagctag aaaaggtatt
     9301 ctagttctaa ttgatatggg ttctttggta attcttggtg atgaggttga aaaaaggctt
     9361 ggaattagat gtaaaactgt aaatagagta gatacattat tggcaatgga agcaggaaaa
     9421 cttgcaacca ttgaagggaa aagtttagat ggtataatag ctgatttaaa gaaaaataag
     9481 aattatgcta tgataaatac aaataaattt agttacagaa aaaacgagta tggaaagaaa
     9541 aatgtaatca ttactttatg tttgagtggt gtaggtacag ctttaaattt aaaagagcat
     9601 atagaaaaac aaattaagga atatgacact ttaattgaag taaagccagt tgctttttta
     9661 aataataatt tagaagaaga gttaaatgat attgaagctg aatataatat tattgctatc
     9721 tgtggaacta ttgatataga ttataaaaac gtgcctttta tttcttataa tgaggtactt
     9781 ggtaaaaatg gtattaataa agtattagag catttaaata gtaaacaacc agctttaaat
     9841 attgaaaacc agttgaataa tttaatacat gaagatttga ttttatacaa ttttgaagga
     9901 atttcaaagg agtatataat tgatactctt gtttcaaaac ttgaagaagg tggatatgtc
     9961 gactcaaagt atatattaag tgtatataaa agagaagcaa tgggaagtgt tgtaatggcc
    10021 tctaaggtag ccgtgccaca tggacttcca gaaaacgtta taaagcctgc aatagcaatt
    10081 gcgaggttga ataaacctat agtatgggac aataaattta tggtggattt ggtggtacta
    10141 ctggcactta aagaaaataa taagaaagaa atacgaagct tattttcaaa gattaatgac
    10201 cagcatactt tagaagtttt attaaatact gaagataaaa atgaaataaa agaactttta
    10261 agctaattgt tagtaccgag aagaaagaca aaaaaatttg ctttagtagt ataaaattta
    10321 aaactactca attgctaagt agttaattac tctatataag gctagttcta tgaaatttat
    10381 ttatatgatt ttatagaatt agcttttttc ttggtaaata aaatatatga atttatttat
    10441 gtaaaaagta aattttattg gacaattcta taaaaatttt tcctatattt cttataaaat
    10501 atagaatata taaaaaatat ataaaaataa attaaattca taataaataa ttttataaaa
    10561 tagttgttaa acataaaaaa ccatttgtaa aaaacaaaaa aatcatttct ctaacaaaaa
    10621 aaaccacaaa aaatataaaa aagtatggct agttaagtga ttaacaagta aaaattaaaa
    10681 taaaaatcaa aaaaaattta tcaatgaaag tcagctaaaa tcctggaaga gagcattatt
    10741 tttgggaaaa cattttcttt tgtttcacaa aaaaagccac tttttggcac acaacatgct
    10801 ttatataaag tcaagaaaaa ctaaggtata agacaaaggc aattaggagg tgtaaatatg
    10861 gagtttataa attttgtaag tgataaagtt atagacctta aaatggattg taaaacgaaa
    10921 gaagatttct ttaaagaaat acataataaa gtttttgatt taggctttgt aaaagaagaa
    10981 tttggagaaa aaatattagc aagagaaaat gtatttccaa caggtttaaa tttaggtgat
    11041 tatggagtag caataccaca tacagatgcg gaatatatta aagagcaatt tatatcagtc
    11101 tgtactttta atgaaccagt agtatttagt tctatggaag accaagatga aaaagtacct
    11161 gtaaatttgg ctttcgtatt aggacttaat caaccacaca gtcaattatc tgtattaaca
    11221 gaattaatgg gaattatgca aaataaagag ttagttgata agttgatgag ttctactgat
    11281 aaagaagaag ttttaaagac actaaagtct ttataaaaat aaaaaagtac taaaaataaa
    11341 aaatataaaa ataaaaatta ttaggaggaa ataaaaatga aaaaaatatt agtagcatgt
    11401 ggagcaggaa tagcaacatc aacagtagtt tgtgacaagg tagagagatt agttaaggaa
    11461 aataatatac aagcagaagt tatacaatgc aaaatagctg aatgtgcaac aaagcaagaa
    11521 ggagcagatt taatagtatc aacaactata ctaccaacaa cttataatat accagcaata
    11581 aaagcaacag catatataac tggagtaaat acagcagcat tagataaaaa aatattagat
    11641 gctttaaaat aatcctatca tagatacatt gaaataatat tttataaaac agaaaaagga
    11701 ggatttataa atggataaat tattagcagt agtacaatac attttaaata tgggaccgac
    11761 agtaatacta ccaataacaa ttgtagtact aggaatgata tttagaatta agtttacaaa
    11821 agctttaaag tcaggtctta caattggtat aggatttgtg ggtataaact tagttgtaaa
    11881 cctattaaca tcaacactag ggccagcggc tcaaggaatg gttgaaagat tcggacttaa
    11941 tttaacagta atagatgttg gttggccaac aacagcatca gcaacatggg cttcaccagt
    12001 tgcaccaata ttaataccag tttgtttatt agtaaactta ctattattat acttcaataa
    12061 aacaaagata ttaaacgttg atatatggaa ttattggcac tttatagtag caggtgcagt
    12121 tggatatata gtaacaggaa gttatgtttg ggctatattc tgtgcaatac taatggagtt
    12181 attagtactg tttattgcag aaaagacagc aaaaaatgtt caggagtttt atgatttaga
    12241 aggtatagca ttaccaactg gttcaacagc ttcatttgct ccacttggat atttagtagg
    12301 taaatttgtt gaaaaaatac caggaataaa taaaatacaa gcagacccag actctataca
    12361 aaaaagattt ggtatatttg gagaaccaat gatgatgggg attatactag gtataatact
    12421 tggagcactt gcgggatatg atgtagcagg aatattcaat gtaggtatat caatgggtgc
    12481 agtaatgtta cttatgccta gaatggttag aatattaatg gaaggtttaa ttccaatttc
    12541 agaatcaata agagatttct tacaagcaaa atatggagac agagaacttt atataggtct
    12601 ggatgcagca gtagcaactg gacatccagc agttatatca acagctctta tacttgttcc
    12661 tataactttg ttcttagcag ttatactacc aggaaacaaa gttttaccat ttggagactt
    12721 agcgacaata ccattttata tggcatttat agtgtgtttt agaaaaggta atatagttca
    12781 atcagttata acaggaacaa tagtaatagc tatatcactt tatatggcta caaactttgc
    12841 agatgttcat acacaattat tacaacaagc aaatatgatg ccagaaggaa caacaatggt
    12901 tacaagtata gatacaggtg gaaacttgct aaaatgggga atattgaaat tatctcaatt
    12961 agtttcttca tttggaatat tctagtatgt agttaataga gattactctt ttttagtaaa
    13021 gtatgcgaaa atttaacatt tagcagctac taaaaaagag taatattttt tataaatttt
    13081 taaaaataca aaatacaaga ggaggagatt tatcgtgaaa gcagcagtat tacatggcac
    13141 aaatgatatg agatttgaag atatagaaat aaaaccatgt gaaagtgatg aagtaaaaat
    13201 aaaagttatg gcagcaggaa tatgtgggtc agatcctcca agagtattaa aacattggaa
    13261 atatccagtt ccagctatac caggacatga gttttctgga gtaattgctg aagttggtaa
    13321 ggatgtaaaa aatgtaaaag ttggagatag agtagttgca attcctttta taccttgtaa
    13381 tgaatgtgaa tattgtaaaa gaggattatt ttcattgtgt gatgaccatg gaatgttagg
    13441 agctaaaagt tttggagctt ttgcagagta tgtaaatata aaagctacaa atgtacttcc
    13501 aataggagat atggactttg aagatgctgc aatgatagag ccactagcag ttgctatgca
    13561 tggagtactt aatataggtg ttcaagttgg agacactgta gccgtaatgg gtagtggaac
    13621 aatggggcag ttggtaatac aaggacttaa aatagcaggg gcaggaacaa ttatagcagt
    13681 tgatatatct gataataaat taagagaatc aaaggaatta ggggctgata taataattaa
    13741 tgctaaagat attaacccag tagaaaaaat aaaagaactt actggtggaa aaggtgttga
    13801 catagctctt gaatgtgcag gttcaaaaat aactcaagaa caatgtttac ttataactaa
    13861 aaagaaaagt aagataggat ttttagggat agcatattca gatataactt tatcagaaga
    13921 agcatttgaa aatatattta gaaaagaact agaattaaaa ggtttttgga actcttattc
    13981 tgcaccattt ccaggacaag aatggactaa gggaatcaat ctagttaatg aaggaaagat
    14041 aaaattaaaa gaaatggtat ctcatagatt ctcacttgaa gatacttaca aagcatttga
    14101 aatgataaga gatagaaaag aagaatttaa caaaatatta attttaccac aaggggttga
    14161 aaaataatga aagcagtagt taaaactaaa ccaggctatg ataatgtaga agttttagaa
    14221 gtagaagaac cgaaagctac aggagacaag gttaaaataa aagtagaata tagtggtata
    14281 tgtggttcag atatacattc atttaaaggt gaatatgcaa atataaaagc cccagtaaca
    14341 ttaggtcatg aattttctgg aattgttgta gaagtaggag aagatgttaa aaatataaaa
    14401 gtaggagata gagttacatc agagactact tttgcaactt gtgagaaatg tatatattgt
    14461 gaaactaaag attataactt atgcccaact agaaaaggta ttggtactca agtaaatgga
    14521 agttttgctg agtatgtatt atcaagagaa gaaagcatac atgtacttcc tgaaaatgta
    14581 tctttattat cagcagccct tacagagcca ctagcttgtt gtgttcatgc agctcttgaa
    14641 aagactacta tagaaagttc tgatacagtt ttaataatag gaccaggacc aattggttta
    14701 ttattagctc aagttgttaa atctcaaggt gctacagtta taatgtctgg tgttacaaaa
    14761 gataaggaaa gattagaaat agctaaaaat cttggagtag atagaactgt aaatgtaatg
    14821 gaagaaagtt tggcagatgt agtgaatgaa atgactgatg gaaatggagt aaacaaagga
    14881 tttgattgtt ctgggtttat gccagcagtt aacgaagcct taagactgct tagaaaaaaa
    14941 ggtactttcg tacaagttgg aatctttgct aaaaaattaa atgaaatgga ccaagaagca
    15001 ataatccaaa gagagttaca atatatagga agtagatctc aaaagccaag ttcttggatt
    15061 acagcattag atttaatggc aagtgggaaa gtaaatacag aagctttagt tactagaact
    15121 gttggtttag acgaatttaa agaaggtatt acagctttaa tgaacgggga agaaataaaa
    15181 gtagcagtaa aatcttaaaa aaacatttgt attattttaa aaaaaattgt aaaatctact
    15241 gtaggataaa aaaatgtaag gtcttaaaaa ataacaggag gaagaaagta tgagcactct
    15301 tagagatcat tctaataata ttagaaaaaa cataataaaa atggttgcag aagctaaaag
    15361 cggacatcca ggtggttcat tatcaatagc tgatatgttg acagtattat attttgataa
    15421 gatgaacgta tgtgcagaaa atccaaaaat ggctgataga gatagatttg ttctatcaaa
    15481 aggtcatgca gcaccagctt tatatgctac attagcagaa aaaggatttt tcccagaaga
    15541 agaattaata acactaagaa aatttggttc taagttacaa ggtcacccag acatgaaaaa
    15601 agtagcagga atcgatatgt ctactggttc tcttggtcaa gggctatctg cagcaaatgg
    15661 tatggcactt gcaggaaaat tagataacaa agactataca gtatatacta tattaggtga
    15721 tggagaaatc caagaaggtc aaatatggga agctgcaatg acagcatcac attacaaatt
    15781 agataattta attgcatttg ttgacttaaa tggattacaa atagatggtt ctaatgaaga
    15841 agtaatgaat gtaaatccag tagatgacaa attcaaatct tttggatgga atgtaatagt
    15901 aataaatgga cattcttttg aagaaatagg aaatgcagtt gatgaagcta aaaaagttac
    15961 aggaaaacca actgtaataa tagctaaaac agtaaaaggt aaaggtgttt catttatgga
    16021 aaataatgct gcatggcatg gaacagctcc aaatgcagaa caagcagagc aagcattgaa
    16081 agatttagaa ggaggtctat aggaatggga atagcaacta gagaagctta cggacaagtg
    16141 ttaaaagaac ttgcagaaaa taaagatata gtagtattag atgcagattt aggaaaagct
    16201 acaaaaagta tatcatttaa agaagttgcc ccagatagat tttttgacat ggggatagca
    16261 gaaggtgaca tgattggtac agcagcaggt cttgctactt gtggaaaaat accttttgcg
    16321 agtacttttg caatatttgc agcaggaaga ggctatgagc aaataagaaa ctctgtagca
    16381 tatccaaatt taaatgtaaa aatagcagct actcatgcag gtgtaacagt aggtgaagat
    16441 ggtggtagcc atcaagctat agaggatata tctctaatga gaggtatacc aaatatggtt
    16501 gtattaaatc cagcagatgc tttagaagca agacaagcta ttcttgcatc tattgattat
    16561 aatggacctg tttatataag attaggtaga gctgcaactc ctgatgtaaa cagtgaaaat
    16621 tataaatttg aaataggaaa aggaactgtt ttaagagaag gttctgacat aacagtaata
    16681 gctacaggaa taatggtagc aaaagcctta gaagcagcag aagaacttgc taaagaaggt
    16741 ataaatgtag aagttgttaa tatatctaca ataaaaccat tagatgaagc actaataaaa
    16801 gaaactgcta agaaaactgg aaaagtagtt acagcagagg agcacagtat aataggtggt
    16861 ttaggttcag ctgtatgtga agctttagca gaaactaaag atgtagtagt tagaagaatt
    16921 ggtgttaaag atgtatttgg tcaatcaggt acaccagctg atttattaaa acactatggt
    16981 ttaactacag aagatatagt aaaaaatata aaagagttgt tatagatata aatatatcta
    17041 aataacaaat tgatttgaca taagtcaatt aaagctgtct taaaaataga aagaaatttc
    17101 tacaatggga cagctttatt tttacaatac tttattttta tgataattat aaaatagtct
    17161 gaaagtaatc aaaaaaatta taaaaagagg tgctatttaa tgaaaatatc tattggatgt
    17221 gaccatggtg gttatgaatt aaaggaatat ataaaggaaa atttaataaa taaaggtata
    17281 gaagttgaag atgtgggtac aaattcaaaa gaaagtgtag attttccaat atatgcaaaa
    17341 aaggtaagtc aaaatgttca aagtaaaaaa tctgatttag gcatactttg ttgtggaaca
    17401 ggaataggta tgtctattgc agcaaataag tttaaaggaa tcagagcagc tgttgtttct
    17461 gactgttttt cagctaaggc aactagagaa cacaataata caaatgtact ttgtttaggg
    17521 gaaagagtta ttgggaaagg attagcaatg agaattgttg aagaatggtt aaattcaagt
    17581 tataatggag aaagacatgc aagaagatta caaatgattg atgatataga aaaagaaaat
    17641 ttataaatat ataatttata acaaggggga gcgttatgtc tattatttgt gcttcaataa
    17701 tgtgtgcaga ccaaatgaag ttaaaagagg aattagaagc tcttgaagaa gcaggtgtaa
    17761 aattacttca ttgtgatgtt atggatggaa tatttgttaa aaacttggct atgggaccag
    17821 agttattaaa atcaataagt gaaaatacaa caataccttt agacatacac ttagccacag
    17881 aaactccaga taaatatatt gatatgatgt cttatataaa gccaaaatat atttcttttc
    17941 atgtagaatc aagtacaaat gtaaaagctg atatacaaaa gttaagaaat tatggtatag
    18001 ggccagtgtt agcaataagc cctcaaacaa gtgtggataa aatagaagaa tatataagtt
    18061 tagttgaggg tatcttagta atgacagtaa atccagggtt tgcaggtcaa aagtttaatc
    18121 tttctgtatt ggataagttg gataaactta cagagatact aaaagattat gataatcctc
    18181 catttataga ggttgatggg aatataaata aggatactat taaacttatg aatggtaaaa
    18241 aagtagatat atatgttgtt ggtacttcag ctttatttaa tgataagcct ccaatttcat
    18301 ataaagataa aatagaagaa ctaaaagaaa gtataaagta accatgtaat aaaattataa
    18361 tatgtttctg tttaatagta aaaatttagg tggaaacaag aaattttata atatttaata
    18421 aaaattttgg ttgagtaagg agaatttttt atgggagacc tatataaact acaaaatggt
    18481 actgatatta gaggaatagc gtatgaaaat gattctaaag aagttaacct aactgtagaa
    18541 gaagtaaaaa aaatagctaa agcgtttcat atttggttaa aagaaaagac taagaaagat
    18601 aaagtaactg ttgccatagg aactgattct aggataacag gaagccaatt tagaagtact
    18661 gttattgaaa ctttaactaa tgacgattgt aatgtaattg attgtgagat tgccacaact
    18721 ccagctatgt ttatgacaac tattatggat ggatacaatt ctgatggggc gattatgatt
    18781 acagcaagtc acttacctta ttactataat ggtttaaagt ttttcacaga aagtggaggt
    18841 ttagaaaaaa ctgatataaa agagatgttg gatatagctg ttaaaaatga tagtgtagac
    18901 tatgaggaag taaataaaaa aggtgaagtt atagtaaaaa atttaataga agattattct
    18961 aatttattga tagataaaat tagaaaaggt gtaaattcaa gtaaaaatta tgaaaagcct
    19021 ttttctgggc ttaagatatt ggttgatgca ggaaatgggg ctggtggatt ctttgctgaa
    19081 aaagttttac acatactggg agcagatacg acaggtagtc agtttttgaa cccagatggt
    19141 atgttcccaa atcatatacc taatcccgaa aacaaagaag caatggaaag catatgtaaa
    19201 gctgtgttgg ataataagag cgatctagga ataatctttg atacagatgt agacagagct
    19261 gctattgtag gtaaaaatgg caaaccaata aataaaaatg ctcttatagc tgttatatca
    19321 tcaatagtat tagaagaaca tccaaaaaca gctatagtaa cagattcaat tacttctgaa
    19381 ggacttgcta aatttataaa tgaattacaa ggaagacatc atagatttaa aagaggatat
    19441 aaaaatgtaa taaatgaagc tataagattg aatagtgaag gtgaagagtg ccatttagct
    19501 atagaaacgt ctggacatgc tgctttaaaa gaaaattatt tcttagatga tggggcatat
    19561 ttaatagcta aaattttgat aaaagtagca aagctatcct tggaaggaaa gactatagaa
    19621 gaattgatag aaaaccttga agaagctcaa gaagagaaag aagttagaat aggcattaat
    19681 aaagaagatt ttagaccata tgcagaggat atattaaaag atttagattc tcatgttaag
    19741 agtattgatg gatggtctgt agcaccaaat aattttgaag gcataagagt taattgtgat
    19801 gaatcaaatg gagatggatg gtttttactt agaatatcac tacatgaacc attattagct
    19861 ttaaatattg aatcaaataa aattggtgga gcagaacaaa tttattctaa gttaaaactt
    19921 ttcttagaaa aatatgattt aaaaggtctt tagggtaaat agaaagaata tatttatatt
    19981 gaagaataaa tgtaaatttg tacctaagat tacaaatatt acaaaattgt aatcttaggt
    20041 aacagagatg taactgatta tggaaacact atgtgatatt atagatacag agagatgaaa
    20101 tatatgatga attatagaga aatataattt aaaatgtatt aatatcacac caaaaaggta
    20161 taatcaaaaa atatgtaaat ataaacccca acatttagaa aaagacctct aaggaggttt
    20221 ttttcttgtt taaataactt aaaatatatt tttatattaa tatatcaatt aactcttcta
    20281 aaagtaagca ttaccttaaa taaatcagca tctataatta tttccatgtg tgcattttct
    20341 aattcaatta tattttgagc aattgataaa ccaagaccag agccatctgt ttttctagat
    20401 atatcacccc ttctaaatct ttctattaac tcttctggct ttagatttag tttatcattt
    20461 gaaatatttt taaacgttaa tattatattt tcttccttta taaacatatc tatgtagacc
    20521 ctagtgttag gcatagagta ttttagtata ttgcaaatta gattctcaaa aactctccaa
    20581 gtttttttac catctatcat ggtaaaaaca gcatattcag gtgtttctat tataaaatct
    20641 aaactgctat tttgaatttt gtcttcaaac tctacaatac tttgaattaa aagttctctt
    20701 atatcggttt ttgttatatt aaattctaca tctccactac ttagcttaga tgcttcaaat
    20761 atgtcatcta ttaataattt taatctttgt gattttttat ctaaaatatt tatatagtca
    20821 tttatagtct ctctgtcaaa gtcattattt tttaacatat caacatagct taatatagat
    20881 gtaagtggag tttttaagtc atgagatacg tttgtgataa gctctgcctt catcctttca
    20941 ttttttatat tagcatctac agcagtttca agaccgcctg ttatattatt tatacttttg
    21001 gctaaagtag atatttcatc atctcctata acttttaatt tatactttaa attgccattt
    21061 tctatatttt ttatattttt tgatatgtta tttatgtaat taaacttaac agataaaaag
    21121 ttgtatatat aaaaatgaaa aactgtgttt acaagtgtaa ataaaattac tatagctatt
    21181 gcctcagcat aatatatata cataaagaat atcaaaacaa g
//
LOCUS       DAEQCW010000064        21140 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.064, whole genome shotgun sequence.
ACCESSION   DAEQCW010000064 DAEQCW010000000
VERSION     DAEQCW010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21140)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21140)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21140
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.064"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            69..1424
                     /locus_tag="KRO40_002335"
     CDS             69..1424
                     /locus_tag="KRO40_002335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093152.1"
                     /translation="MDTKISINENMSLGKRFFKYLAPSVVAMWVFSLYTMVDGIFVSK
                     GVGELALAAVNISMPFINFIFAVSLLFSTGASTIIAIYLGKKDIKSANEVFSFNLVSI
                     IILSIIILAITFFNLDRLALFLGATESTIGMVKDYLGIIIFFNGFFIVSYSLEVIIKT
                     DGFPILATVGVIISALTNIILDYLFVIEFGWGVKGAGIATGLSQVFSTIFFLIHFLRK
                     NSTLNFSKFRIDFKTLRKIVFIGFPDSTTELSCGIVVLLFNLSLTKYIGENALIYYSV
                     INYINTLVLMTMMGITQGMQPLTSFYYGAGNIDNVKKLLKMGIKATIIASVAVFAICM
                     AFSGPIVSLFIHPEETMLFNEGVRVFKIFSISFLLVGINVIISGFFVSVEKPSISTVI
                     SLGRGLVIVVLSLISMILIFGGQGIWMTTIVSEFICLILSLVFLKKNFSTLDSNLNKV
                     A"
     gene            complement(1542..2210)
                     /locus_tag="KRO40_002336"
     CDS             complement(1542..2210)
                     /locus_tag="KRO40_002336"
                     /EC_number="6.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphthine--ammonia ligase"
                     /protein_id="HBH2093153.1"
                     /translation="MKEVLKLADEKFVMSFSGGKDSILALNRMLKKGYKPVALLTTIS
                     EEHGKSWTHNLEYNMLKQVSSNIGLPLLVAECGVEGYEESFERALIKAKNMGATICAY
                     GDIDIESHRKWDTDRCEAVGMKVDLPLWQESREDLVYEFIDSGFCSVVTKVNLKHLGE
                     EFLGKKLTRELVEKIKNAGADPCGEHGEYHTFVVDGPIFKKPVEYEVKGTLIKDGYGY
                     LEIK"
     gene            complement(2277..2705)
                     /locus_tag="KRO40_002337"
     CDS             complement(2277..2705)
                     /locus_tag="KRO40_002337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH2093154.1"
                     /translation="MTKLWAIIFALLAGGSTALEAFINGELGKSTTALVATFISLTVG
                     AIFFLASIIVTGDLKCLVSINGFNYKLLLGGVFGGLIIYFTVKAIPNLGVSNTLILTL
                     VSQVLVGFFIDSVILGQETMHLYKYIGVILLILGTFFIVN"
     gene            2812..3405
                     /locus_tag="KRO40_002338"
     CDS             2812..3405
                     /locus_tag="KRO40_002338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF308 domain-containing protein"
                     /protein_id="HBH2093155.1"
                     /translation="MNFCYNCSIDFGGDFMYTNFNIDFNNFNKKENAIKFMLMGVLLI
                     ILGLLCLTFKTLGIKLISWTFGIALLFFAYLNLKNINELKRYATKEEIKPSINIQWVL
                     IIACILLFVFPQKIQSIFSLFLGFYLIFNQLVALVNSKNNPYSKFTTWNIVKILFGIC
                     LILSPLFLSRFIVSIMSFFIILFGLVLFFSGNTARKY"
     gene            3524..4459
                     /locus_tag="KRO40_002339"
     CDS             3524..4459
                     /locus_tag="KRO40_002339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893027.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
                     /protein_id="HBH2093156.1"
                     /translation="MDKFKYAFDNKRYHTWNYYLRNTFGEKVFKVSINAGFTCPNIDG
                     SLGYGGCTYCSKEGSGDFAGNPKDNLISQFYNIKEMMLKKWPHAKYIGYFQAYTNTYA
                     PLEVLKEKYETILELEDVIGLSISTRPDCLPDDVVEYLSELNKRTNLWVELGLQTIHD
                     STSKIINRGHDYKTFVEGVEKLKSKNIKVVVHIINGLPGEDYNMMMETAKAVGKMGVD
                     GIKIHLLHVIKDTPMEKMLQNGMLTLMEQDEYINLVCDQLEILPETMIIHRLTGDGKR
                     DELVGPIWSLKKWEILNQIDDTLKARNSYQGCKFV"
     gene            complement(4731..5675)
                     /locus_tag="KRO40_002340"
     CDS             complement(4731..5675)
                     /locus_tag="KRO40_002340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBH2093157.1"
                     /translation="MGEKSKGYVFIAIAGLLWATLGLFGKFLMGNGLTSEQVAFTRLF
                     FGFIVLGVYSSIRTPQILKISKKGIIYSVIIGIICQAMFNLCYFKAIDIAGVSIAAVL
                     LYTSPLFLAIFSKICYKENITRSKLFSLILCFIGAIMAVTGGRLDFQGLNAFGLLLGV
                     LSAIAYALMPTISKNALKEFSSSTILVYSFLFGAIFMIPSSRPWEILNYAKDLDVLSC
                     MLMLGIVPAALAYIFYAAGISKGVELSVAGVVASVELVGSVIIGCTILGESFSLGKLF
                     GVMLMLISAVVALNLSYDEIRIFYKSNKLKQIEKTESI"
     gene            5993..7423
                     /locus_tag="KRO40_002341"
     CDS             5993..7423
                     /locus_tag="KRO40_002341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093158.1"
                     /translation="MNLDLEFYQKILEASHDEICVSDDKGIIIYCNKAFEENYGLKKE
                     DILGKNVSFLEDSGYSTKSPIPIVLKTKTKFSLEQDTQTGKKLIITATPIFDENGNLE
                     FTVENCRDITELNNIKNKLEDTKKQVKKYKSEVETLYRTALRIEDTVIMDGIVMRPII
                     NTVNHVSKTDVSVLLLGESGTGKSSLARYIHHNSNRSNGPFITINCATISPQLLESEL
                     FGYTSGAFTGASTKGKVGLVELANGGTLFLDEIGDIPQNLQAKFLQLIQDRTFTPVGS
                     LKNKKVDIRIISATNVDLVSKVKEKKFREDLYYRLNVIEIKLPPLRERRDNLVEIIKY
                     YFNRYSSDFNLNKTISKEAMDAIANYRFPGNIRELQNIIQKILLTCTDNHITIDDLPN
                     ILTKNIHITNNGNKTHISQINKVIISDSKSTNYKNKNFDTLIKEYEKNIILDAYEKFG
                     SSYKVAKHLEISQSKANRLIRKYTNT"
     gene            7623..8207
                     /locus_tag="KRO40_002342"
     CDS             7623..8207
                     /locus_tag="KRO40_002342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc dependent phospholipase C family protein"
                     /protein_id="HBH2093159.1"
                     /translation="MLMNTHFIMAKSILDNIDENKTFFISEKNFIYGNIKPDAFSKYK
                     LKKHYLDESFNMIVSKINYLCSLNIDSLSKYFSVSRLSQELGVICHFLCDFFCVAHSE
                     RWEFKHSLNKHVTYERELGAFAKDVDLSKIKCGTINSSFEKFFTKLYSDYKKKTDYMN
                     DLKFSAYTCNSVINYILDSILSNTIKSYHIANCG"
     gene            complement(8311..9090)
                     /locus_tag="KRO40_002343"
     CDS             complement(8311..9090)
                     /locus_tag="KRO40_002343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH2093160.1"
                     /translation="MIKHIFCDLDGTLYENGTITKEDIVAIEEIEKKGVQFNVATGRI
                     FKQAHNIIKDSLDMNGYYVCENGSFIYDKDYNVIFKRTIDDNLVKKVIDRFESSDAQL
                     YFKYKGDVIVGSDTTAFRHYSSDFIVDPDFEKRSSFDNLIGNIGVCSENLEELSRIEL
                     YLKSEFSEVLEIYFSGTYTLNIVPKSVSKRGSIEHVIKTLNVSPDEVATIGDSPNDIC
                     MLEGFKYSFAMSKAREDVKQSANYVVDSVKSAIDVIMEINS"
     gene            complement(9148..10404)
                     /locus_tag="KRO40_002344"
     CDS             complement(9148..10404)
                     /locus_tag="KRO40_002344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HBH2093161.1"
                     /translation="MKAEIISVGTEILLGDIVNTNSQFLAKELASLGIEVYHQSTVGD
                     NKQRLLECFDESLKRSDFVITTGGLGPTGDDMTKETAAEYFGQKLELHKPSLEVLESF
                     FVKTGKKMAENNMKQVYFPKDAIVLKNNNGTAPGAILKKDGKFIIVLPGPPREMKAMF
                     NESVKPYLQQFTNEMLVSKTLRLYGIGESNLELEILDIINEQTNPTVALYAKELEVTI
                     RITAKAENEREAFKLIKPVEEKIKSRVGKYVYTEGDISISEGETALEDAVSKLLVEKN
                     LTIAVAESCTGGLVSSSLINYPGISSVFLEGCVTYSNDSKMKRLGVKRETLEEFGAVS
                     EQTAIEMAEGVAKGLKANIGISTTGVAGPGGGTKEKPVGLVYTAIYINGKTIVKKNIF
                     NGDRRKIRLRATRDLLNELRIQLEKL"
     gene            10662..11561
                     /locus_tag="KRO40_002345"
     CDS             10662..11561
                     /locus_tag="KRO40_002345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HBH2093162.1"
                     /translation="MKIAVIMGGISSEREVSLNSGKEIYNNLDKNKYEVVKVIIDDKK
                     DIFTKIPEDIDFAILALHGKFGEDGCIQSILETMDIPYSGCGPLCSGMCMDKNITKKM
                     LRDSNLPTAPWVLVKSVDEIDYDEIDNIGYPVFIKPNSGGSSVATFFIHSKDEVEEAV
                     RKGLEVDEFVMIEKYIPGGEYTSFILNGEVFPTISIKSDSGFFDYEAKYSVEKGAKEE
                     VVYLDEELQKRVNEISETCWKIFNCKAYVRVDMIISEGIPYVLELNTLPGMTQTSLIP
                     RSAAARGIKYSELLDKLIEYSLN"
     gene            11585..13033
                     /gene="ddlR"
                     /locus_tag="KRO40_002346"
     CDS             11585..13033
                     /gene="ddlR"
                     /locus_tag="KRO40_002346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator DdlR"
                     /protein_id="HBH2093163.1"
                     /translation="MIFSNLKLNDNEPIYIQLKNYISDMISKGLIPDNSKLPSTRELS
                     QLLQVSRNSVVLTYEELKSEGLIYSISGKGTFVKSKNKSSNTTWSLNWDCLENTYSKK
                     ANELDIIKSEIPWSSDLISFKSISPDGDLFDIEELKKSFLNRISLEGHKLLNYGYAQG
                     YKPLIDYLLEYMTNKGADISNKDILITNGFTEGFDIIMSSFTQEKDYIICENPTHNTA
                     IKIMKSHNLNILGVDINEDGLDFNMLEDNLVKYKNKIKFAYITPSYHNPTGIVMTPEN
                     RYKFYNLMKKYNIAIIEDGFNEELLYNSSHIFPICSLDNMNNGVVYIGSFSKILFPGM
                     RIGWIFADKKVINKLESVKRCRNIHVSFLDQGILFDYLSNGGFEKYIKKIRKFYGDKF
                     NFAYKCIKKYIKTEYILGDGGLHIFIKLKNIDTRVLLEKCYEKNVIFMPGDLFFTDNS
                     GFDTLRLGFSRLSFEDIEIGIKIIGETINEMF"
     gene            13092..13898
                     /locus_tag="KRO40_002347"
     CDS             13092..13898
                     /locus_tag="KRO40_002347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH2093164.1"
                     /translation="MNLILGDNMSKKSKRRKINKLKLTIVITVLFLALLSIYEILFSN
                     PNKKGNIKSQETMQNKNNTTDDSKNNQSSTKKQEDNNIKPTFSYSSIPDNIKNKMIGK
                     SMPTDEPISFDSLSYLKLTYYGFDEKTHQGEMIVNSELAPEVVDIFKELYEKKYPIEK
                     IKLIDDYDAVDEKSMSDNNTSSFCYRTIAGTNVVSNHGKGRAIDINPLQNPQVSGNDV
                     TPKVSTVYADRSSTKFGMIKKGDDCYNAFVSRGWSWGGYWKNPDYQHFEK"
     gene            13924..15843
                     /locus_tag="KRO40_002348"
     CDS             13924..15843
                     /locus_tag="KRO40_002348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_071223118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBH2093165.1"
                     /translation="MNLMTLENISKSYSEKKLLENISLGINEGEKIGLIGVNGTGKST
                     LLKIIAGVEESETGNITKTNGIRIEYLPQNPTYNENSTVLEQVFNGTSEELKLLGEYQ
                     EILEKLNSNFTEELNKKLLSVHEKIDALNLWDLESEAKSVLTKLGINDFNQKIAELSG
                     GQRKRVSLASALITPCEFLILDEPTNHLDNDTIDWLEEYLNSRKGSLLMITHDRYFLD
                     RVTNRIIELDKGRLFSYDGNYSIFLEKKMERLSLEASIEDKRQNLIRTELAWVRRGAQ
                     ARSTKQKARLQRFDELINRDSFKPDENLDISVASSRLGNKIIEIHNISKSFEENTVID
                     NLEYTLTRTDRIGIIGKNGMGKSTLINILNGEIEPDSGYISIGETVKIGCFSQDDSHM
                     NIDMRAIDYVKEASDYIETSDGTRITASQMCERFLFNGTMQYTLIGKLSGGERRRLHL
                     LKILMTAPNVLLLDEPTNDLDIETLKILEEYLDEFKGVVVTVSHDRYFLDRICNKIFA
                     YEGNGKIHIYTGNYSDYLIYREIQGIEFEESKRESVKKDDSTTPKKEKPKNDKKLKFS
                     YNEQREFENIDSDIEKLESKIATLDESTAKFSTDFTKLQEILDEKSKLEKELEYKYER
                     WEYLNNLADEIANNK"
     gene            complement(16085..16432)
                     /locus_tag="KRO40_002349"
     CDS             complement(16085..16432)
                     /locus_tag="KRO40_002349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PqqD family protein"
                     /protein_id="HBH2093166.1"
                     /translation="MSKSNDVLDIVFKITDGLEYEVAENRVVTILEKQDHKIQKFFRK
                     LKARIPKYKKIELDEYSSFVFLQIDGQRTVREIGKNLEAKYGEESHPLYERLLVFLNH
                     IEVNCHYIERLDI"
     gene            complement(16419..18347)
                     /locus_tag="KRO40_002350"
     CDS             complement(16419..18347)
                     /locus_tag="KRO40_002350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide transporter, OPT family"
                     /protein_id="HBH2093167.1"
                     /translation="MNKKLPKGAYGEVSGKDYVPYITDKSRTGGNVAVLIIGIILAAI
                     FAASTTYSGMKAGLTVAAGIPGAIIGSAFVGAFARSKGILGKNLIQGMSSGGESVASG
                     FIFVLPAVILIGSQITFLEGLAVGVGGVLFGIGIAAIVHNYLIVEEHGKLMYPESMAI
                     SETLVASEAGGDSIKYMGIGFVISGFITVLTGSFLNVANNVMSLVGSKFYKWKFDIEV
                     NPLLLGIGFIVGLEVSLTMFAGSILSNFGIAPLIGYFTDMAKDGAMVWNNPAMPLNQM
                     DVGAISSSYVKYIGAGMMLCGGIIGAIKLIPTIIASIKETLKAKSSAGEGEEGSSIQM
                     ILLLGGVVIGFLAAFLISGNIVMAIIGAIISLLLSLLFVIVAGRLTGTIGTSNLPVSG
                     MTIASLVIVTLVFVIMGWTDLEANKSLLLFGSFIVVAIAIAGGYTQSQKVTYIIGGSK
                     NEMQRYFTIASIVGVIVVVGVILLLSDQLRATGDNVQFALPQANLMSTLTSGIMSGSL
                     PWVMIIVGVFMAIVLYALNLPIMTIAIGFYLPIATTSIILVGALIRLFVELVSKTEKE
                     KEVKVSNGISLSSGLVAGGSIIGLIGIILQVTGVVTPKVPSGFAATNSMAIALLVVLV
                     VLTALPIVLSKVKNNEQE"
     gene            complement(18759..20948)
                     /locus_tag="KRO40_002351"
     CDS             complement(18759..20948)
                     /locus_tag="KRO40_002351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid adenylation domain-containing
                     protein"
                     /protein_id="HBH2093168.1"
                     /translation="MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVF
                     KMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKYIYEDDVVFGKTMNIIPIRVRVR
                     QSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
                     EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDL
                     EFVCKEEEKVLLEDFNNNQYEVPYDKSYVDLFREQVKVTPSNIAARDENRKLTYKELD
                     EVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGAFFPIDTSNPEERLN
                     YLLEDSNAKVVITTDELKSKVVNENTIVLDINDEEMFKFGYELTEKITSSNCAYTIST
                     SGSTGRPKTIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVG
                     ASIDIMPEEAKFDEYTVNEYCEENDITILALPTAFARLFIQNCNNNSLRVVQTGGERL
                     KGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKKNKLCPI
                     GAPGELCLSGIQISRGYLNKKGLTEQVFVENPYKTCEHNKLMYRTGDLVRWLDDGNLD
                     YIGRMDNQVKIDEFRIELYEIENIINNITEIKSVVCISRTNDDGDIYICAYYVIDEED
                     SGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIGKVNKRALPE"
BASE COUNT         7706 a         3157 c         2720 g         7557 t
ORIGIN      
        1 atattagaat aaaattatta attaatagtt tcgtaatttt ataatagatt tacagggagt
       61 gataataaat ggatacaaaa atatctataa acgaaaacat gagtctaggt aaaagatttt
      121 ttaaatacct agcaccatct gtagttgcaa tgtgggtttt ctcactatat acaatggttg
      181 atggaatatt tgtaagtaaa ggagttggag aattagcttt agctgctgtc aatatatcaa
      241 tgccttttat taattttata tttgcagttt ctctattatt ttcaactggt gcatctacca
      301 taattgcaat ctatctgggg aaaaaagata ttaaatctgc taacgaagtc ttttcattta
      361 acttagtatc aataattata ttatcaataa ttatattagc tataactttt tttaatttag
      421 atagattagc actattttta ggagctacag aatctacaat tggtatggtt aaagattatt
      481 taggaataat aatatttttt aacggattct ttatagtgtc ttattcttta gaagttataa
      541 taaaaactga tggctttcca atattagcta ctgttggtgt aataatatct gctcttacaa
      601 acatcatact tgattacttg tttgtaattg aatttggatg gggtgtaaaa ggtgctggta
      661 ttgcaactgg tttgtctcaa gtcttttcta ctattttctt cttaatacat tttttaagaa
      721 aaaactctac tttgaatttt tcaaaattta gaattgattt taagacactt agaaaaattg
      781 tatttatagg ttttcctgat tcaactactg aattaagttg tggtatagtt gttttacttt
      841 ttaacttaag tcttactaaa tatattggag aaaatgctct tatttattat agtgtcataa
      901 attatataaa tacattagta cttatgacta tgatgggtat aactcaaggt atgcaaccac
      961 ttactagctt ttattatggt gcaggaaata tagataatgt aaaaaaatta ttaaaaatgg
     1021 ggataaaagc cacaataata gcatcagttg ctgtatttgc aatttgtatg gctttttcag
     1081 gaccaatagt ctctttattt atacatccag aagaaacaat gctattcaat gaaggagttc
     1141 gtgtatttaa aatattctct atatctttct tattggtagg aattaatgta ataatttctg
     1201 gattctttgt atcagtagaa aaaccatcaa tttctactgt tatatctctt ggtagagggc
     1261 ttgtaatagt tgttttaagt ctaatttcaa tgatactaat atttggtgga caaggaatat
     1321 ggatgactac tattgtttct gagtttatat gtcttatttt atcattagtt tttctaaaaa
     1381 agaatttttc tacattagac tctaatctaa ataaggttgc ttagatgata agagtgacaa
     1441 tatatgaaaa tatctaaata aaaaatacct attatacaat cttgcaaata ttaaaccttt
     1501 gcaaaaatta ggattatata ataggtattt tatttatgta attattttat ttctaaatat
     1561 ccatagccat cttttattaa agttcctttt acttcatatt ctacaggttt tttaaatatt
     1621 ggaccatcta cgacaaatgt atgatactct ccatgttctc cacatgggtc tgcaccagca
     1681 ttttttatct tctccacaag ttctctagtt aatttttttc ctaaaaattc ctctcctaag
     1741 tgctttaagt ttacttttgt tacaacacta caaaatccac tgtctataaa ttcatatact
     1801 aaatcctctc tactctcttg ccataatggt aaatctactt tcataccaac tgcttcacat
     1861 ctatcagtat cccattttct atgactttct atatctatat ctccatatgc acatatcgtt
     1921 gctcccatgt ttttagcttt tattaaagcc ctctcaaagc tctcttcata tccttctacg
     1981 ccacactcag caactaataa aggtaatcct atgttgctac ttacttgctt aagcatatta
     2041 tattctaaat tatgtgtcca tgactttcca tgttcttcac ttatagttgt caagagtgcc
     2101 acaggcttat atcctttttt caacattcga tttaatgcta atatactatc cttaccacca
     2161 ctaaatgaca ttacaaattt ttcatcagcc aattttaaca cctctttcat ctaactttgt
     2221 tttattaaca taattatacc aaatttttga gttgcatagc aaattatatt aaattgttaa
     2281 ttcactataa agaatgtccc taatattaaa agtataaccc ctatgtattt gtataaatgc
     2341 attgtttctt gtcccaaaat tacgctatca ataaaaaatc caactaaaac ttgggataca
     2401 agagttaata taagtgtatt tgatactcct aaatttggaa ttgcctttac tgtaaaatat
     2461 attattagac ctccaaatac tcctcctaat aacaacttat aattaaaacc atttatagat
     2521 actagacact ttaagtcacc tgtaactatt atacttgcca aaaaaaatat tgctcctaca
     2581 gttaagctta taaaggtggc cactaatgct gttgtacttt ttcctagctc tccatttata
     2641 aaagcttcaa gagctgtaga accacctgct aataatgcaa atattattgc ccataatttt
     2701 gtcatggaca aacctccttc tatataattc tattaataga agtttatgat acaacctatt
     2761 aattaattac taagtatagt ttaattttta tacactaggc tttatttgga tatgaatttc
     2821 tgttataatt gttctatcga ttttggaggt gattttatgt acacaaattt taatatcgat
     2881 tttaataact ttaataaaaa agaaaatgct attaaattta tgttaatggg agtattactc
     2941 attatattag gattattatg ccttacattt aagacattag gtataaaatt aatttcttgg
     3001 acttttggta ttgcactttt attctttgca tatttaaatt taaaaaatat taatgagtta
     3061 aaaagatatg ctactaaaga agaaattaaa ccctctatta atatccaatg ggttctaata
     3121 attgcatgta tattactttt tgtatttcct caaaaaatac aaagcatatt ttcattattt
     3181 ttaggatttt atttaatctt taatcaacta gtagcacttg taaatagtaa gaataatcct
     3241 tattctaaat ttacaacttg gaatatagtt aagattctat ttggtatatg ccttatatta
     3301 tctccacttt ttttatctag atttatagta tcgataatgt cttttttcat aatattattt
     3361 ggactagttc tatttttctc tggaaataca gcgagaaaat attaattatt ttctcgctgt
     3421 atttttatat tacttaaaat agaatttgtt taagttatct atttgtggta atatgttttt
     3481 tgtacaagct cagcgtacaa ttttattaga aataggtgat tttttggata aatttaaata
     3541 tgcttttgat aataaaagat atcatacttg gaattactat cttagaaata cttttggaga
     3601 aaaagttttt aaggtatcta taaatgcagg atttacttgc ccaaacattg atggaagtct
     3661 tggttatggc ggatgtacct attgtagcaa agaaggctca ggtgattttg ctggaaaccc
     3721 taaagataat cttatcagtc aattttataa tataaaagaa atgatgttaa aaaaatggcc
     3781 tcatgcaaag tatattggct actttcaagc ctatacaaat acgtatgctc ctcttgaagt
     3841 tttaaaagaa aaatatgaga ctatattaga acttgaagat gtcataggtc tttcaatatc
     3901 cacaagacct gactgtttgc cagatgatgt tgtagaatac ttatctgaac taaataaaag
     3961 aaccaattta tgggttgaac ttggacttca aacaattcat gattctacat ctaaaattat
     4021 aaatagaggt catgattata aaacatttgt tgaaggtgtt gaaaaactaa agtctaaaaa
     4081 tataaaggtt gtcgtacaca ttataaatgg tcttcctggt gaagattata atatgatgat
     4141 ggaaacagca aaggcagttg gtaaaatggg tgtagacggt ataaaaatcc atctattgca
     4201 tgttataaaa gatactccta tggaaaagat gttacaaaat ggtatgttaa ctcttatgga
     4261 acaagatgaa tatatcaatc ttgtctgtga ccaattagaa atacttcctg aaactatgat
     4321 aatccataga ctcactggtg atggtaagag ggatgaacta gtaggtccta tatggagcct
     4381 aaaaaaatgg gaaattttaa atcaaattga tgatacttta aaggctagaa attcttatca
     4441 gggctgtaag tttgtttaat acaaaataat aactatagaa atggttatat aaatatagtc
     4501 ctttctatag ttatttagta tttacaaaaa caaaatatta atttgtacat ttatacaata
     4561 tataataaaa aatagatagt ctaaactgta tctacttata ttttatttgt actgtccact
     4621 ttattctata aaatttataa atagttattt tttaatacca aatataattt ggtataattt
     4681 ttgttggact ctaaaatgta taccaataaa tcctttttaa gtatataatt ctaaatactt
     4741 tcagtttttt caatctgctt taacttgttg gacttataaa atattcttat ttcatcataa
     4801 gaaagattaa gtgctactac tgcagatatt aacatcaaca tcactccaaa taacttccct
     4861 aaggaaaaac tttctcctaa tatagtgcaa ccaattatta ctgaaccaac taattctact
     4921 gatgccacaa cacctgcaac tgacaactct acacctttag atatacctgc tgcataaaaa
     4981 atatatgcaa gtgcagctgg aacaatgcct aacattagca tacaagataa aacatctaaa
     5041 tccttagcat aatttaagat ttcccaaggt cttgaagaag gaatcataaa tatagctcca
     5101 aataagaaac tgtatactaa tattgttgaa cttgaaaatt cctttaaagc atttttacta
     5161 atagttggca taagtgcata tgctattgct gataataccc caagtaaaag tccaaaagcg
     5221 tttaaacctt gaaaatccaa acgtccacca gtcactgcca taattgcacc aataaaacaa
     5281 agaataagtg aaaataattt gcttctagta atattttctt tataacatat ttttgaaaat
     5341 attgctaaaa acagtggtga tgtatatagt aaaactgctg caattgatac acccgcaatg
     5401 tcaattgctt taaaataaca taaattaaac attgcctgac atataatacc tattattact
     5461 gaatatataa ttcctttttt gcttatcttt aagatttgtg gtgtccttat agatgaatat
     5521 acgcctaaaa ctataaatcc aaaaaacaat cttgtaaatg ctacttgttc tgatgtcagt
     5581 ccatttccca ttaaaaactt tccaaataat ccaagtgtag cccataataa ccctgctatt
     5641 gctataaata catacccttt acttttttct cccattttaa attcccttct atttttattt
     5701 agtcaattta cactcttctt tttaagcaaa aactatgcca tcttaaatca atatatatcg
     5761 actctaaaac cctagtcttt ccaataatac taataaattt tcaatttttt tatatttatt
     5821 tttcacttac tttaagttga tttagactta ttttaattgt aaaatgagtt atatataact
     5881 tatttaaagt taaaatagac tgaaacttat atataaatat caaattttaa gtatattaat
     5941 caattaaacc tattttaata tatcattaaa aatttaggag gaaaatataa aaatgaattt
     6001 agatttggaa ttttatcaaa aaatattaga agcttcccat gatgaaatat gtgtttctga
     6061 tgataaagga ataataatat attgtaataa agcatttgaa gaaaattatg gtctaaaaaa
     6121 agaagatatt ttaggaaaaa atgtttcttt tttagaagac tctggatatt caacaaaaag
     6181 ccccatacca attgtattaa aaacaaagac taaattttca ctggaacaag atactcaaac
     6241 agggaaaaag cttatcataa ctgctacccc tatatttgat gaaaatggaa acttagaatt
     6301 tactgttgaa aattgtagag atataactga acttaataat ataaaaaata aacttgaaga
     6361 cacaaaaaag caagtaaaaa aatataaatc tgaagtagaa acactataca gaactgcact
     6421 tagaattgag gatactgtaa ttatggacgg aatagttatg agaccaatca taaacacagt
     6481 aaatcatgtt tctaaaacgg atgtaagtgt acttttattg ggtgaatctg gaacaggaaa
     6541 aagctcactt gctagatata tacaccacaa cagcaataga tctaatggcc catttataac
     6601 aataaattgt gcaactatat ctccacaact tcttgaatct gaactttttg gatatacttc
     6661 aggtgctttt acaggtgcaa gtactaaagg taaagttggg ctcgtagaat tagctaatgg
     6721 aggaactctt tttttagatg aaataggaga tataccacaa aatctacagg caaaattttt
     6781 gcaattaata caggatagaa cttttactcc agttgggagc ttaaaaaata aaaaggtcga
     6841 tataagaatt atatctgcta caaatgttga tttagtttca aaagtaaaag aaaaaaagtt
     6901 tagagaagat ttatactata gattaaatgt tatagaaata aaattgcctc ctcttagaga
     6961 aagaagggat aatctagtgg aaattataaa atattatttt aataggtact caagtgactt
     7021 caatctaaat aaaactattt ctaaagaagc tatggatgct attgcaaatt atagattccc
     7081 aggcaatata agagaattac aaaatataat tcaaaaaatc ttgcttactt gtacagataa
     7141 tcatataaca atagatgact taccaaacat tcttacaaaa aatatacata ttaccaataa
     7201 tggaaataaa acacatatat cccaaattaa taaggttatt atatctgact caaaatctac
     7261 taattataaa aataaaaatt ttgacacttt aattaaagag tatgaaaaaa atataatttt
     7321 ggatgcttat gaaaaatttg gtagttctta taaagtagcc aaacaccttg aaatctcaca
     7381 gtctaaagcc aataggttaa ttagaaagta tactaatact taattttaaa tttgataaat
     7441 aaaaacttaa cactatttac atattgtaaa tttggccatt tactgttatt atgaatatgg
     7501 ttgaaattat ttaaataaat actgttgact tagtttcata tatttaccat taaactttta
     7561 tcataaatat catatcataa taatatattt aataagtcta ataaactata cgaggtgtaa
     7621 atatgttaat gaatacccat tttattatgg caaaatcaat acttgataat atagatgaaa
     7681 ataaaacatt ctttataagc gaaaaaaatt ttatatatgg caatataaag cctgatgctt
     7741 tttctaaata taaattaaaa aaacattatt tagatgagtc atttaatatg attgtttcta
     7801 aaataaacta tctatgcagt cttaatatag atagtctttc taaatacttt tcagtaagta
     7861 gacttagtca ggaactagga gtcatatgtc attttttatg tgattttttc tgtgtagctc
     7921 acagtgaacg ttgggagttt aagcatagct taaataaaca tgttacttat gaaagagaac
     7981 ttggagcatt tgcaaaagat gttgatttat ctaaaattaa atgtggtact ataaatagta
     8041 gttttgagaa gttttttact aaactttata gcgattacaa aaagaaaact gattatatga
     8101 atgatttaaa attttcagct tatacttgta atagtgtcat aaattatata cttgactcta
     8161 ttttatctaa tacaataaaa tcatatcata tagcaaattg cggttaactt aagaattttt
     8221 aaacttatat aaacttataa ttgaatataa ttaaaatgac tgctctatag aatataattt
     8281 tatacttctc taggacagtc attttttata ctaactattt atctccatta taacatctat
     8341 ggcacttttt acactatcta ctacataatt tgcactttgc tttacatctt cccttgcctt
     8401 agacattgca aaactatatt taaatccttc taacatgcaa atatcatttg gagaatcccc
     8461 aatagtagca acttcatctg gacttacatt taacgttttt attacatgct ctatacttcc
     8521 tctttttgac acacttttag gaactatatt taaagtatat gttccagaaa aatatatttc
     8581 taagacttca ctaaactcac tttttagata aagttctatt ctggataact cttccaaatt
     8641 ttcagaacat acgcctatat ttcctataag attatcaaaa ctacttcttt tttcaaagtc
     8701 tgggtcaact ataaagtcac tagaataatg tctaaaagca gtggtatcac tacccacaat
     8761 tacatcaccc ttatatttaa aataaagttg tgcatcactt gactcaaatc tatcaatgac
     8821 tttttttact aaattatcat ctatcgttct tttaaaaatt acattataat ctttatcata
     8881 tataaatgaa ccattttcac atacatagta tccattcata tctaaactat ctttgataat
     8941 attatgtgct tgtttaaaaa ttctacctgt agcaacatta aactgtactc cctttttttc
     9001 tatttcttca attgctacta tatcttcttt tgttatggtt ccattttcat atagagttcc
     9061 atctaaatca caaaatatat gttttatcat aaattaaaag cctccaaaaa caattttata
     9121 ttttactaat actttaatca aaataactta aagcttttct aattgtattc tcaactcatt
     9181 aagcaaatct ctagtagctc ttaatcttat ctttcttcta tccccattaa atatattttt
     9241 ctttactatt gtttttccat ttatatatat tgcagtataa accagtccca caggcttctc
     9301 tttggttcct ccaccaggtc cagctactcc agttgtagat atacctatat tagctttaag
     9361 tcctttagca acgccctcag ccatttctat agctgtttgc tcacttactg ctccaaactc
     9421 ttccaaagtt tctcttttta ctcctaatct tttcatttta gaatcattag aatatgttac
     9481 acaaccttca agaaatacag aggatatacc tggatagttt ataagagatg aagaaaccaa
     9541 acctccagta caagattcag ccactgctat tgttagattt ttttctacaa gtagcttaga
     9601 aacagcatct tctaaagcag tctccccttc agatatggaa atatctcctt cagtatatac
     9661 atatttacca actctacttt ttattttttc ttctactggt tttattaatt taaaagcttc
     9721 tctttcattt tcagcctttg cagttattct tattgtaact tctaattctt ttgcatataa
     9781 agcaactgtt ggattagtct gctcattaat tatatcgaga atttctaatt ctagatttga
     9841 ctcacctatt ccatataatc ttaaagtctt agatactagc atttcatttg tgaattgttg
     9901 taagtaaggt ttgacactct cattaaacat agctttcatt tctcttggag gtccaggcaa
     9961 tactattata aatttaccat ctttttttaa aattgcccct ggagctgtac cattattatt
    10021 ttttagtact atagcatctt ttggaaagta cacttgtttc atattatttt cggccatttt
    10081 tttccctgtt ttaacaaaga aagattccaa aacctctagt gaaggtttat gtagttctaa
    10141 tttctgacca aagtattctg cagcagtttc ttttgtcata tcatcaccag ttggcccaag
    10201 accacctgta gtaattacaa aatcacttct ctttaagctt tcatcaaaac attctaaaag
    10261 tctttgtttg ttatctccaa cagtactctg atggtatact tctattccca atgatgcaag
    10321 ttctttagct aaaaattgag aatttgtatt tactatatct cccaataata tttctgttcc
    10381 tacacttatt atttcagctt tcaaaattta tcactccttg atttatagcc attaagacta
    10441 gtcttaagtt cataacaata attttagcaa aaataataac ataaataaag ttaaaaaatc
    10501 atttaaacat atctttaaac tagattatta ttctaaaacc acacataata taaacttcgt
    10561 atatagtggt actttcatcc tcaactgtta attcatataa ttaagtatgt aaataaaaag
    10621 tttactttaa aataataaaa attaaaatag gagtgtataa tatgaaaata gcagttataa
    10681 tgggtggaat atcatcagag agagaagttt ctttaaattc aggaaaagag atatataata
    10741 accttgataa aaataaatat gaagttgtaa aagtaataat agatgataaa aaagatatat
    10801 ttacaaagat accagaagat atagattttg caatacttgc tttacatgga aaatttggtg
    10861 aagatggatg tatacaatca atacttgaga ctatggatat accatactct ggatgtggac
    10921 ctctttgcag tgggatgtgt atggataaaa atataactaa aaaaatgctt agagattcaa
    10981 acctacctac tgctccatgg gttttagtaa aatcagttga tgaaatagac tatgatgaaa
    11041 tagataatat aggttatcca gtatttataa aaccaaactc aggaggttca agtgtagcca
    11101 cattctttat tcattctaag gatgaagttg aagaagcagt tagaaaaggt ctggaagttg
    11161 atgaatttgt aatgattgaa aaatatatac caggtggaga atatacttca ttcatattaa
    11221 atggagaagt gttccctaca atatctataa aatctgattc aggattcttt gattatgaag
    11281 ctaagtactc agttgaaaaa ggtgcaaagg aagaagttgt ttacttagat gaagaacttc
    11341 aaaaaagagt aaacgaaatt tctgagactt gttggaaaat ttttaattgc aaagcatatg
    11401 taagagttga tatgattata agtgaaggta ttccatatgt tcttgaacta aatactcttc
    11461 ctggaatgac tcaaactagt ttaattccta gaagtgctgc tgctagaggt attaagtaca
    11521 gtgaactatt agataaactt atagaatact ctttaaatta gatgaaataa tttgaggtgg
    11581 taatttgata ttttcaaatc taaaactaaa tgataatgaa ccaatttata tacaacttaa
    11641 aaattatata agtgatatga tatcaaaagg actaattcca gacaatagta agctcccttc
    11701 tacaagggag cttagtcagc ttttacaagt tagccgaaat tctgtagttt taacttatga
    11761 agaattaaaa tcagaaggat taatctactc tatttcagga aaaggtacat ttgttaaatc
    11821 aaagaataag tcttcaaata ctacatggtc attaaactgg gattgtttag agaatacata
    11881 ctctaaaaaa gccaatgaat tggacattat aaaaagtgaa attccttgga gctctgacct
    11941 gatttccttt aaaagtattt ctccagatgg agatttattc gacatagaag aattaaaaaa
    12001 atccttttta aatagaattt cactagaagg acataaatta ctcaactatg gatatgcaca
    12061 aggttataag cctcttattg actatttact agaatatatg acaaataagg gtgctgatat
    12121 aagtaataaa gatatactaa taacaaatgg attcacagaa ggctttgata ttattatgtc
    12181 atcttttacc caagaaaaag actacataat atgtgaaaat cctactcata atactgctat
    12241 aaaaattatg aaatctcata acctcaatat cttaggtgta gatataaatg aagatggttt
    12301 ggacttcaat atgctagaag acaatttagt taagtataaa aataaaataa agtttgcata
    12361 cattacaccc tcttatcaca atcctacagg aattgtaatg actcctgaaa ataggtacaa
    12421 attctataat cttatgaaaa aatacaatat agcaattata gaagatggat ttaatgaaga
    12481 attactctac aatagttctc atatatttcc tatctgttcc ctagataata tgaataatgg
    12541 ggtcgtatat attggtagtt tttcaaaaat tttatttcct ggaatgagaa ttggatggat
    12601 atttgcagat aaaaaagtaa tcaataagct agaaagtgta aaaaggtgca gaaacataca
    12661 tgtatccttt ttggaccaag gaattttatt tgattattta agtaatggag gttttgaaaa
    12721 atacattaaa aaaatacgta aattctatgg ggacaaattt aactttgcat ataagtgtat
    12781 aaaaaaatat ataaaaacag aatatatctt gggtgatggt ggtttgcata tatttataaa
    12841 actaaaaaat atagatacta gagttttatt agaaaaatgt tatgaaaaaa atgttatatt
    12901 tatgcctgga gatttatttt ttacagataa ctctggtttt gatactttaa gactcggatt
    12961 ttctaggttg tcttttgaag acattgaaat tggaataaaa ataattggag aaactataaa
    13021 tgaaatgttc taggttaact aaatattgtt agcctagttt atttttatga ggtataatat
    13081 atatagttta tatgaatcta atactggggg ataatatgag taaaaagtca aaacgaagaa
    13141 aaattaataa attaaaatta acgattgtaa taactgtatt atttcttgct ttattatcta
    13201 tatatgagat actgttctct aatcccaaca aaaaaggtaa tataaagagt caagaaacta
    13261 tgcaaaataa aaataataca acagatgatt ctaaaaataa tcaaagctct accaaaaagc
    13321 aggaagataa taatatcaag cctacttttt catattcttc aataccagat aatataaaaa
    13381 ataaaatgat tggtaaatct atgcctactg atgaacctat aagctttgat agtctatctt
    13441 atttaaaact tacatattat ggatttgatg aaaaaactca tcaaggagaa atgatagtaa
    13501 acagtgaact agctccagaa gtagtggata tttttaagga attatacgaa aaaaaatatc
    13561 caattgaaaa aattaagtta atagatgact atgatgctgt agatgaaaaa tctatgtctg
    13621 ataataatac ctcatcattt tgttatagaa ctatagctgg tacaaatgta gtttcaaatc
    13681 atggtaaagg acgtgctata gatataaacc cattacagaa tcctcaagtt tctggaaatg
    13741 atgttacacc taaagtaagt acagtttatg ctgataggtc tagcacaaaa tttggaatga
    13801 taaaaaaagg tgatgattgt tataatgctt ttgtaagcag aggttggagt tggggtggct
    13861 attggaaaaa cccagattat caacattttg aaaaataata gattagaaat aaaggtgaat
    13921 tatatgaatt taatgacatt ggaaaatata agtaaaagct attctgaaaa aaaattacta
    13981 gaaaatatat ctcttggaat aaatgaaggg gaaaaaatag gacttattgg tgtaaatggt
    14041 actggtaaat ctaccttact caaaattatt gcaggagttg aagaaagtga gactggtaat
    14101 ataacaaaaa ctaatggtat taggatagaa tatctacctc aaaatccaac ttacaatgaa
    14161 aattcaactg tacttgaaca agtatttaat ggaacttctg aagaattaaa gctacttggt
    14221 gaatatcaag aaatcctaga aaaacttaat tcaaacttta cagaggaatt aaataaaaaa
    14281 ttattatcag tacacgaaaa aatagatgcc ttaaatcttt gggatttaga aagtgaagct
    14341 aagtcagtac ttacaaagct tggtataaat gactttaatc aaaaaatagc agaactttct
    14401 ggtgggcaaa gaaagagagt ctctctggca tcagccctta ttacaccttg tgagtttttg
    14461 atactagatg agcctacaaa ccatctagac aatgatacta tagattggct tgaggaatat
    14521 cttaattcca gaaaaggctc attgcttatg ataactcatg atagatactt tttagaccgt
    14581 gttacaaata gaattattga actggacaaa ggtagattat tcagttatga tgggaattat
    14641 tcaatatttt tggaaaagaa aatggaaaga ctttcgctag aagcaagtat tgaagataaa
    14701 agacaaaatt taataagaac agagcttgcg tgggtaagac gaggagctca ggctcgtagc
    14761 actaaacaaa aagctcgttt acaaagattt gatgaactta taaatagaga ttcttttaaa
    14821 cctgatgaaa atcttgatat atctgttgca tcaagtagac ttggaaataa aataatagaa
    14881 atacacaata tatctaaatc atttgaagaa aatactgtta tagataattt agaatacact
    14941 ttaactcgta cagatagaat tggtataata ggcaaaaatg gtatgggtaa atctaccctt
    15001 ataaatatac ttaatggaga aatagagcct gatagtggat atatttcaat tggagaaacg
    15061 gttaaaatag gttgtttttc tcaagacgac tctcatatga atattgatat gagggctata
    15121 gactatgtaa aagaagctag tgactatata gaaacttcag atggtactag gattacagct
    15181 tctcaaatgt gtgaaagatt cctttttaat ggtactatgc aatatacttt gataggtaaa
    15241 ttatctggtg gtgaaagaag aagactacat cttcttaaaa tccttatgac agctcctaat
    15301 gtgcttcttt tagatgaacc tacaaatgat ttagatattg aaacgcttaa aatattagaa
    15361 gaatacctag acgaatttaa aggtgtagta gttacagtat cacatgatag atatttctta
    15421 gatagaattt gtaataaaat atttgcatat gaaggtaatg gaaaaattca tatctataca
    15481 ggtaattaca gtgattatct tatttataga gagattcaag gaattgaatt tgaagaatct
    15541 aaaagggaat cagttaaaaa agatgactct actaccccaa aaaaagaaaa acctaaaaat
    15601 gataaaaagc ttaagttctc atataatgaa caaagggagt ttgaaaatat tgactctgat
    15661 atagaaaaac tcgaatctaa aattgcaaca cttgatgaaa gtactgcaaa attttcaact
    15721 gattttacta aactccaaga aattttagat gagaaatcta aactagaaaa agaacttgaa
    15781 tacaaatatg aaagatggga atatttaaat aatctagctg atgaaatagc taataataag
    15841 taatattaaa ataatcttaa gtttaataag ttttgcttta aatctgtaat ttataaatat
    15901 tttaaaggaa gtgtctcaaa atgaactttt tagttttatg agacactctt ttttatgaga
    15961 aatcaaatat attttcatca tttcaacaat acaaaagagg cttatctcta ttttgagaca
    16021 gcctctttca taattacctt ctaatttata tgctctaata tatctataat aattcttatt
    16081 atatctatat atccagtctt tcaatatagt gacaattaac ttcaatatga tttaaaaata
    16141 ctaacaacct ttcataaagt ggatgagatt cttctccata tttagcttct aggttcttgc
    16201 ctatttctct aacagtcctt tgaccatcaa tttgtaaaaa aacaaaactg gaatattcat
    16261 ctagttctat ttttttgtat ttaggtattc tagcttttaa ctttctaaaa aacttttgaa
    16321 ttttatggtc ctgtttttca agtatagtaa caacacgatt ttcagctact tcatattcaa
    16381 gtccatcagt aattttaaat acaatatcta aaacatcatt actcttgctc attatttttt
    16441 actttagata aaacaatagg taatgctgta agcacaacta aaactactaa taaagcaatt
    16501 gccattgaat ttgttgcagc aaatccactt ggtacctttg gagttacaac tccagttact
    16561 tgtaatatta tacctattaa accaatgata gaaccaccag caacaagacc agaagataaa
    16621 cttataccat tagaaacttt aacttctttt tctttttcag ttttagatac taattcaaca
    16681 aataaacgaa ttaatgctcc aactaatatt atagaagtag ttgcaattgg taaatagaat
    16741 cctatagcta tagtcattat tggtaaattt aatgcatata gaactattgc cataaatact
    16801 ccaacaataa tcataaccca aggtaaacta cctgacataa taccagaagt taatgttgac
    16861 attaagtttg cttgtggtaa tgcaaattgt acattatcac cagttgctct aagttggtca
    16921 gaaagtaata aaattactcc tacaacaact ataacaccaa ctatacttgc aattgtaaag
    16981 taacgttgca tttcgttttt gctaccacca ataatataag ttactttttg agattgagta
    17041 taacctccag ctatagcaat agcaacaact ataaatgaac caaataaaag taatgattta
    17101 ttagcttcta aatcagtcca tcccattata acaaacacta atgttacaat aactagagaa
    17161 gctatagtca taccagaaac tggaagattt gatgttccga ttgttcctgt taaacgacca
    17221 gctactatga caaataataa agataataaa agagatatga tagctccaat aattgccata
    17281 acaatgttac cagaaattaa gaatgctgct aaaaatccaa taactactcc acctaataaa
    17341 agtatcattt gtatagatga accttcttct ccttctccag cacttgattt agctttaagt
    17401 gtttctttta tagaagcgat tatagttggt ataagtttta ttgcaccaat aatacctcca
    17461 caaagcatca taccagcacc tatatatttt acataactac tagatattgc tccaacatcc
    17521 atttggttaa gaggcattgc aggattattc cataccatag ctccatcttt agccatatct
    17581 gtaaagtatc ctattaaagg tgctatacca aagtttgata aaatacttcc tgcaaacatt
    17641 gttaaagaaa cttcaagccc tactataaat ccaattccta aaagtagagg atttacttca
    17701 atatcaaatt tccatttgta gaatttgctt cctacaagac tcattacatt gtttgctaca
    17761 tttaagaatg aaccagttaa tacagtaata aatccactta ttacaaatcc aattcccatg
    17821 tacttaattg aatctccacc agcctctgaa gcaacaagtg tctcagatat agccattgat
    17881 tctgggtaca taagtttacc atgttcttca actattagat agttgtgaac tatagcagca
    17941 atccctatac caaataaaac tccaccaact ccaacagcta agccttctaa gaatgtaatt
    18001 tggcttccaa ttaatataac tgctggtaat acgaaaataa atccacttgc aacagattct
    18061 ccaccacttg acataccttg gattaagttt ttaccaagaa taccctttga acgagcaaat
    18121 gctccaacaa aagcagaacc tattatagct cctggaatac ctgcggcaac tgtaagaccg
    18181 gctttcattc cagagtaagt tgtagatgcg gcaaaaatgg cagctaaaat aataccgata
    18241 atcagtacag ctacatttcc accggttctg gacttatctg tgatatatgg aacgtaatct
    18301 tttccactaa cctcaccata agcaccctta ggtaattttt tgttcataaa attttcaccc
    18361 cttttcaatt tgtatatatt ataacatata tacatataaa acttaacttt ttattatttt
    18421 acaaatagcg agtcaaaact actaaaattt aaccctatat tattaatttc tacttttaga
    18481 tatttttatg ctaattttct ttttattttt caattctact aaaaactatt aagatataaa
    18541 ataaaaaaat tttttaatgt aaaattaatt ttgtaaaaaa aatgctttaa aacacggaaa
    18601 agtataaaaa atacaataat cattcttata aataaatttt caccatagta aatatataca
    18661 gaaaattctt gtttttatgc aaattgatta ttttataaaa ataagtgtca taaagaaatg
    18721 tctgaaatca ctttatgaca cctatcataa taaaaaaatt attctggtaa tgctctttta
    18781 tttacttttc cgattggtgt aactggtatc ttatctatcc tcattattat tgttggaatc
    18841 atatatggag gtagatgctc atttaaatat tctctaatag ttctttcatt tatcttacca
    18901 ctatcttcct catcaattac ataatatgca catatataaa tatctccatc atcatttgtt
    18961 ctcgatatac aaacaacact tttaatttct gtaatattat ttattatatt ttcaatctca
    19021 tatagctcta tcctaaactc atcaattttt acttgattgt ccatccttcc aatataatct
    19081 aaatttccat catctaacca tcttactaaa tcaccagttc tatacattaa cttattatgt
    19141 tcacaagttt tgtaaggatt ctctacaaat acttgctctg ttagcccttt tttatttaaa
    19201 tatcctcttg atatttgaat gcctgataga catagctctc ctggtgctcc aattggacat
    19261 agtttgttct ttttatctaa tacatatgca taagtattaa atataggttt tcctattggt
    19321 atttttccat attctctgtc cacatgaaaa gaagtcgata caacagtaaa ttcggttggt
    19381 ccatactcat tatatagttc ataattacgc tttctatatc cttttaatct ttctcctcca
    19441 gtctgtacaa ctctaagtga attattattg caattttgta taaataacct tgcaaatgct
    19501 gttggcaatg ctagtatagt tatgtcattt tcctcacagt attcatttac tgtatattca
    19561 tcaaatttag cttcttcagg cataatatct attgatgcac ctacaagcaa ataagggaat
    19621 agttgtttca ttacagcatc aaaactgaaa cttaagtata taccacatat atcattttct
    19681 gtagcgctta tagattttac gctataataa cacatattta ctaaactctt atgttctata
    19741 gctatggtct ttggcctacc agttgaccct gaagtagata tcgtatatgc acaatttgat
    19801 gatgttattt tttcagttaa ttcatatcca aacttaaaca tttcttcatc atttatatcg
    19861 agtactatgg tattctcatt tacaacctta cttttgagtt catctgtagt tatcactact
    19921 ttcgcattac tatcttcaag aaggtaattc aatctttctt ctggattact tgtgtctatt
    19981 ggaaaaaatg ctccccctga tttcataatc cctattgctg taataattat gttaatatct
    20041 cttggtaaca ttacagctac tatgtcttca ctttccactc ctatatgatt taaataacct
    20101 gcaagtttat cagttacttc atccaattct ttatatgtta actttctatt ttcatcccta
    20161 gcagctatat tactaggtgt taccttaact tgctccctaa ataaatcaac ataactttta
    20221 tcatagggta cttcatattg attattatta aagtcttcca ataatacttt ttcttcttcc
    20281 ttacatacaa attctaaatc ttctattaaa atatcattat cttctattat ttgctctatt
    20341 atataatcaa attgatttaa aattcttcta atagtttctc ttttatatat agatggttta
    20401 tactttattt ttattttaag tgccctctta gtatatacta ttacagataa atcatatcct
    20461 tttttttcta tgtcataatc atatgataaa tcaaaacttt tagctataaa tattgtgttt
    20521 ataagcttag tatttagatg atttttattc tctatatctg ataacaaata gtatccatac
    20581 tctaaagacc tgctccactg cctttttagc ttccttacaa catctataaa tttttcactt
    20641 tgtctaactc ttactcttat tggaattata ttcattgttt taccaaaaac tacatcatct
    20701 tcatatatat acttttgaag tataaggcca tatatagttt ctatgataga gtctatgcta
    20761 atattgttca ctttagaata ttgaattaac ctttcatgtt tctcaatatt catcttaaaa
    20821 acctcatcta ctacttcatc agaacaatct ttataaaaaa aatcatttgg aatttttgct
    20881 atattcgtat aatcatctaa caaatccatc caataattca tagctcgttc taaattaact
    20941 tcatacatat caaaattccc ccttactact aagtctatag aaaaaattct tttggaattt
    21001 tattttcaca atatataaat atattaataa tacatatgca agctctaaaa acatgagctt
    21061 gcataaaatt acacttatta tgactactaa attcgtaata tttacaatgt ttaaaatata
    21121 ttataacaca tatatgattt
//
LOCUS       DAEQCW010000065        20861 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.065, whole genome shotgun sequence.
ACCESSION   DAEQCW010000065 DAEQCW010000000
VERSION     DAEQCW010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20861)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20861)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20861
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.065"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            278..667
                     /locus_tag="KRO40_002352"
     CDS             278..667
                     /locus_tag="KRO40_002352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093169.1"
                     /translation="MKINKLPHAELKLMKYIWGVDDVLASRDIIEDMKLKYDWKKSTT
                     LTFLKNLVDKGFLTTDKVDRCTHYTIAIKEKDYLKVETKSFFSFMHNNSFKSFISALH
                     DDEVLDSKSLDKLEEYFKNLKEEDIDD"
     gene            987..1496
                     /gene="vanZ1"
                     /locus_tag="KRO40_002353"
     CDS             987..1496
                     /gene="vanZ1"
                     /locus_tag="KRO40_002353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycopeptide resistance protein VanZ1"
                     /protein_id="HBH2093170.1"
                     /translation="MKSRKHNITKGLFIVYIIILTWIILFKLQFDISSLETMNLRSIN
                     LIPFAGSLIINNRVDISEIILNVAIFVPFGIYVCMLKEEWSFIKKVIPIFITSLVFET
                     LQYIFALGASDITDLIGNTLGGIIGIAVFMLLSKIFKNNTIKIINVLALIVTIIVVLF
                     LGLVIFANL"
     gene            complement(1598..1792)
                     /locus_tag="KRO40_002354"
     CDS             complement(1598..1792)
                     /locus_tag="KRO40_002354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase"
                     /protein_id="HBH2093171.1"
                     /translation="MSVIVMCSRCGKEIDKYRNKYITYYEKNTNAEIKVCINCALDLL
                     EKTRENQELNIQEFQDTIIL"
     gene            complement(2308..2700)
                     /locus_tag="KRO40_002355"
     CDS             complement(2308..2700)
                     /locus_tag="KRO40_002355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2093172.1"
                     /translation="MAALKSFEKPLTPEEEIEYLTKFKIENDKSAKDTLIERNMRLVA
                     YIAKKYNNSTEDQDDLISIGTIGLIKAIETYNIDKGTRLATYASRCIENEILMNIRSN
                     KKNKTQVSLQDPIGTDKEGNEINTTLYM"
     gene            3267..3629
                     /locus_tag="KRO40_002356"
     CDS             3267..3629
                     /locus_tag="KRO40_002356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093173.1"
                     /translation="MKIRKSGFISIECIISIAILYVAVYLVSTSLYNCYSFISRNISD
                     REMLSTAKKYIEDEKYRIQNSKYELIEDKIEKNYINGYEINSKIEQILDYYQCYEINI
                     EIKNEFKKLRFNSYVTRK"
     gene            3613..4338
                     /locus_tag="KRO40_002357"
     CDS             3613..4338
                     /locus_tag="KRO40_002357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093174.1"
                     /translation="MLLENKGSILIITLIIFSIISTVCIMCIGLIYTHNNMFELGYKD
                     IQLKEISLSGIEISVSNVLSCVEEAIDVSNNEDEFREYFLGNNMIECIKKIKDTSYSS
                     LEELSLKVENNTIYDRGDFFEFDIESNVREKEFLKAIKVRVKIKNPWIGIDIEDYMDK
                     SNNNKIDDKTFNNYKASENNEILNQFKNESENIRNQEVGGFTEEDEEDEEYEEELKQN
                     IIENIKKNFDEKNLVQVYKYRGV"
     gene            4358..4777
                     /locus_tag="KRO40_002358"
     CDS             4358..4777
                     /locus_tag="KRO40_002358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093175.1"
                     /translation="MTVIELIVSISIILLIVTLSFPKDNLENHKINLFARQLCSDIRY
                     VRRINMFSNYNTYIYYINQGKHEGYVLRKDGKNIKSIMLPKNAKIARSIEIIKFKSDG
                     SPQKASTIEIYNNRLRKTITITPVSGRVLLKEGKYET"
     gene            4767..5291
                     /locus_tag="KRO40_002359"
     CDS             4767..5291
                     /locus_tag="KRO40_002359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093176.1"
                     /translation="MKHKYGYLLLESVVSLSSMVIIILVLYSIFLSTINLKLKVEDKI
                     ELQQQSLEIIKSMEGIISNSMGIMNVSNYEETFKKTTSIKCRYLDENNNEEGISNKEI
                     ILNERRNKLFVNSLNGESSQAGGYEIGDYVDEMYVSITNNGQYVNIKLKLSKRSQKYE
                     TDFKIKVWNFSESI"
     gene            5603..6160
                     /gene="efp"
                     /locus_tag="KRO40_002360"
     CDS             5603..6160
                     /gene="efp"
                     /locus_tag="KRO40_002360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HBH2093177.1"
                     /translation="MVSAGDFRKGVTFEKDGQPCLVVDFQHVKPGKGAAFVRTKYKNL
                     KTGAIREESFNPSEKFPKAVIDTRQMQYLYNDGELYYFMDQENFEQIPLNYEQVEDAI
                     KFLKENEVATIRFYQGQPFQVEAPNFAELEVTDTEPGIKGDTASNVTKAATVETGAVV
                     QVPLFINTGDKVKIDTRTGEYLSRV"
     gene            6252..6707
                     /locus_tag="KRO40_002361"
     CDS             6252..6707
                     /locus_tag="KRO40_002361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH2093178.1"
                     /translation="MKHLYEEVAYLKGLAEGLEISAESKEGKMIHKIVDALEVFADAI
                     VTLDEEQEELQDFVESIDEDLADLEEDIADMEEDLYEEDDDEDDEDFSYIEMECPNCG
                     ELVEIDEDLLYDDEVDVVCPDCKAVILSSEDDCDDDCTCGGCSSCDDRE"
     gene            6870..7580
                     /locus_tag="KRO40_002362"
     CDS             6870..7580
                     /locus_tag="KRO40_002362"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HBH2093179.1"
                     /translation="MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKY
                     NFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTKLRANIVCEDSLSEVANDINLGI
                     HMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
                     NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKK
                     EAEQLAAKIALKKKLWEK"
     gene            7634..8704
                     /locus_tag="KRO40_002363"
     CDS             7634..8704
                     /locus_tag="KRO40_002363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2093180.1"
                     /translation="MKKRIIPIFVPHKGCPHDCIFCNQKKITGVSTDVTSEDARNIIE
                     ECLETIDKDADVEIAFFGGSFTAIDIDIQKSLLSVAKEYVEKGLVKDIRMSTRPDCID
                     EDILSMLKEYKTSIIELGVQSLDEKVLLDSIRGHQSEIVYKSSKMIKNSGIKLGLQMM
                     IGLPADTEEKCIFTAKKFVELKPDCVRVYPTLVVKDTGLEKLMEQNKYNPFTLEESVN
                     IVKKVLVLFYVNNINVIRVGLQATDDIQIGKAVLAGPYHPAFRELVEADMIKDYLEFV
                     ILQNKNIKQMLVKSNKKNISKIIGNKKTNVKYMEEKFGVLLKTQESDLDINQLEIVLD
                     GKSLISANMRDIHRKLYDIYDL"
     gene            8732..12286
                     /gene="smc"
                     /locus_tag="KRO40_002364"
     CDS             8732..12286
                     /gene="smc"
                     /locus_tag="KRO40_002364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HBH2093181.1"
                     /translation="MYLKRLELKGFKSFPVKTDIIFKEGITAIVGPNGSGKSNISDAV
                     RWVLGEQSIKSLRGDKLEDVIFAGTDTKKPMNYCEVALTIDNSENQLELDFTEVTIRR
                     RAYRNGESEFFLNNKSCRLKDIKEVFLDTGIGKDGYSIIEQGKVDEILSNNPLSRRKV
                     FDEACGISKYRYKKQEAERNLSNTKENLERIDDVYIEIENQLKPLFNQQTKAKKYLEI
                     SEKLKTLEVNSFIREIEGIEKELSEVNEHRKVIEKELNEKEEQKNVVEKKQEDINKEV
                     EVLQDVIEKSVDYINSIKGVISKKESQINLIKERIRNFTNEISRKNLEIKDIKEKLNE
                     NKQYIKELESNKLSGSEELSTLQENIKVLEGSKDKQKIKLESLNNEIELLKESIIDIL
                     NKKQEFSNKLSTLNANKENMNIRDENINSEITELNKNIEIKSSELDTINKEFNMQNEN
                     LKNVNNRHKELSINLQDSISEHNKLEDEIQKSKYNLNGYNSKLNVYIDMENHYEGFNR
                     GVKEVLKNKNLKGVHGALGQIINVPEKYEKSIEAALGAYMQNIITDNEFSAKFAINYL
                     KQNNLGRVTFLPLNIIKSNKISLGNLKANTKFIGIASDLITFDEKYRNIIENILGRTI
                     LINNIDEGIKFAKETGHRFKIVTLDGEILNPGGSLTGGSLKTNGNILSRKRYINEYTE
                     KISNIKNEISHLELKRESLDKDVKNIKNEIDSHESKIKDLEKSIIIKSTSIKNVESEI
                     ESLKGSITKLENEKNDLNSNLNYTLEKSDDVRKDMEELDDLYNKNKEKIDALNEEIKR
                     YNDLYDKEKSEFDELNLSLVKKTEVYNSIVRDIKRISGENCELEEKNKQLEESLNYEE
                     HEIIKLQDSILTEEKEKENLTKQLGDSNRNLETRKIAKDDLKNSFDEINKELKTIDRQ
                     HIELKESLFKVGGRLERLKTSQDTYINKLFEQYDMTLVQALEIKDEDLDIDRKFLESL
                     KREIRSLGNINIDSIKEYEEIKERYDFYSEQKQDLEESMEEIEKLIHTLEENMKSEFE
                     IKFEEISKNFKYVYKRLFGGGCGELTILDKENLLESDILITAQPPGKKMKNLNLLSGG
                     EKALTAISILFAILITKPTPFCILDEIEAPLDDANIFRFGEFLKDLSKETQFISVTHR
                     RGTMEAADYIYGVTMQEKAISKVISLKLKEAQEITDII"
     gene            12313..13593
                     /gene="ftsY"
                     /locus_tag="KRO40_002365"
     CDS             12313..13593
                     /gene="ftsY"
                     /locus_tag="KRO40_002365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HBH2093182.1"
                     /translation="MLKKLFGFGKDKEKEIEKKDAEEEIEVEDSVDNLENLEETIFSG
                     LEEEVIDKVEDIEEKNEESVNNEGTEEIENFEKIEVEMDSNGKEVENISNNDSQEEII
                     EELENYDEIESKEIEDKEDKKVNLFERLKQGLTKAKQGITDRIDEVLKSYTKIDEELL
                     EDLEEILITADVGVNTTMDIIERLRDKIKQKGITEPIKVREELKSIVEDILTNENSTL
                     DIEPAPCIILMVGVNGVGKTTTIGKLANRYKKDGKKVLLAAADTFRAAATEQLEIWAN
                     RTNVDIIKHQEGADPGAVVFDAIKAAKARKTDVLICDTAGRLHNKANLMNELGKVFKI
                     VDREFPEAKREVLLVVDATTGQNAVVQAKTFKEVADITGIVLTKLDGTAKGGVVLAVK
                     SEVDVPVKLIGVGESVEDLQDFNAKSFSDALFGN"
     gene            13696..14064
                     /locus_tag="KRO40_002366"
     CDS             13696..14064
                     /locus_tag="KRO40_002366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HBH2093183.1"
                     /translation="MNIEKMVEIGLLFEQYKELLTDKQKEIVALYYEEDYSLGEISEN
                     LNVSRQGVYDTLKRSEKILRDYEEKLHLVSKIQEQEKNIKIIKDKIIDIKEDLLHNRD
                     CANLIPKLENIEDVCREMIK"
     gene            14061..15413
                     /gene="ffh"
                     /locus_tag="KRO40_002367"
     CDS             14061..15413
                     /gene="ffh"
                     /locus_tag="KRO40_002367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HBH2093184.1"
                     /translation="MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADV
                     NFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVNEELTSLMGDVQSKVMISSKPPT
                     ILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
                     NMGDKENPINIAKAGLSHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEIL
                     LVVDSMTGQDAVNVAESFNEALGVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMG
                     EKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELEQKIKKQELDFEDFL
                     QQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPG
                     VLNASRKKRIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
                     "
     gene            15451..15723
                     /gene="rpsP"
                     /locus_tag="KRO40_002368"
     CDS             15451..15723
                     /gene="rpsP"
                     /locus_tag="KRO40_002368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HBH2093185.1"
                     /translation="MAVKIRLKRMGANKKPFYRIVVADSRAPRDGKFIEEIGYYNPIS
                     EPKQVRINDEKAIKWLATGAQPTEVVKKLLVKNGVIEKFEASKQAK"
     gene            15788..16015
                     /locus_tag="KRO40_002369"
     CDS             15788..16015
                     /locus_tag="KRO40_002369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HBH2093186.1"
                     /translation="MKELVVDIAKALVDNPDSVVVEEFEDNDGIVLKLTVAQEDMGKV
                     IGKQGRIAKAIRTVVRSVANRENIKVSLEIV"
     gene            16123..16638
                     /gene="rimM"
                     /locus_tag="KRO40_002370"
     CDS             16123..16638
                     /gene="rimM"
                     /locus_tag="KRO40_002370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA processing protein RimM"
                     /protein_id="HBH2093187.1"
                     /translation="MKEKLTHFKVGQIVNTQGLKGEVRVYPLTDDIERFDELKDFYLG
                     KDLNNKLAVEKVRYKGSMVIMKIKGIDSIEKAEKLKNKFMYVAREDSRELEEGEFFIA
                     DMIGMEVLTVDGKYVGILEDVLQYSANDVYVVKGEEDKEFMIPAIKKFVPTIDIDERK
                     MIIDPIKGMID"
     gene            16647..17342
                     /gene="trmD"
                     /locus_tag="KRO40_002371"
     CDS             16647..17342
                     /gene="trmD"
                     /locus_tag="KRO40_002371"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HBH2093188.1"
                     /translation="MRFHIMTLFPEIFNSYMDESIMKRAVEKGIIEVHIYNIRDFSNN
                     KHKKVDDYPFGGGAGMVMTPQPIYDTYKHIITTHNINNPSVIYLTPKGKVYNQSMAKQ
                     MSLKEDIILLCGHYEGIDERIIDLIVTDEISIGDYVLTGGELPALIMIDSISRLIPGV
                     LNQEESFEEESFKDNLLEYPHYTRPRDFEGLKVPEVLLSGNHKKIDEWRREESIRITK
                     ERRFDLYKKSNEK"
     gene            17527..17877
                     /gene="rplS"
                     /locus_tag="KRO40_002372"
     CDS             17527..17877
                     /gene="rplS"
                     /locus_tag="KRO40_002372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HBH2093189.1"
                     /translation="MNEMLRAIEQEQLKNEVPNFGPGDTVKVHVRIIEGKRERIQVFE
                     GVVLKRQGGGARETFTVRKMSFNVGVERTFPVHSPKIEKIEVTRKGKVRRAKLNYLRG
                     RVGKAAKIKEARNK"
     gene            18198..19094
                     /gene="ylqF"
                     /locus_tag="KRO40_002373"
     CDS             18198..19094
                     /gene="ylqF"
                     /locus_tag="KRO40_002373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HBH2093190.1"
                     /translation="MSNEYEEYLMNDNLHINWYPGHMKKTKELVKNNLKLIDVVIELL
                     DARIPFSSKNPDIDRLVGDKPRVVVLNKSDMADRDKLNQWIEYYKKINIKAIPVDTIK
                     GVGINKIIEECKNVTREKMSSLKDKGRKERAIRIMIVGVPNVGKSSLINKLTGRKSTQ
                     TGDKPGVTKGKQWVRLKGNLELLDTPGILWPKFEDQEVALNLAFSRAIKDEILDTETL
                     ALRLIEKLMKIEPEKLKARYKLDCLGETPIETMDMIGHKRGFITGKKELDYTRIATTV
                     LNEFRDGKIGNITLEVPENVKR"
     gene            19483..20775
                     /gene="brnQ"
                     /locus_tag="KRO40_002374"
     CDS             19483..20775
                     /gene="brnQ"
                     /locus_tag="KRO40_002374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH2093191.1"
                     /translation="MGKTKDVIVFGFALFAMFFGAGNLIFPPYLGIITGPEWLIAFLG
                     FTFADAGLALLAVMATAKFDGNVVEMFKRCGMKLGILIGCADILCIGPFLAIPRTGAT
                     TYEMGIMPLFGTSIPVLLFCILFFAISYVLTIRPSKVVDIVGQFLTPALLIALAFIII
                     KGIISPLGDIVDKPMIPNVFAEGIGQGYQTMDAFAAIALASVLIVSLNDKGYSTISDK
                     LKMIGKAGVLACGGLALVYGGLCFLGATVSTMYGTDAVQSQVIVNITEGLLGNVGKAI
                     LAVVVSLACLTTSIGLTSATGQYFSRLTKGKLSYEKIVLAVSVFSAVVASFGVGTIIK
                     IASPILSIVYPPSIVLIILAFFNEKIKNDNVYKGAVYMSLLVSILTVISSYGVAVPVV
                     NSLPLNSLGFNWVVPVIIAGIIGNFIPSKSQSNTLGTN"
BASE COUNT         8763 a         1951 c         3751 g         6396 t
ORIGIN      
        1 tgtatttaag cttatagatt ataatgaaat ataatacatg ttgcaataat aaaacgaact
       61 aaaattatca cactaaagca taaaacatac tctaatcatg ttagataaat ttttgaatat
      121 ataatccaaa agtactctct aaagtagagt acttcttttt tattaattat ttttatatag
      181 aataaattgg aatttatatt tattccaatc taattgatta catacactta ttgttataaa
      241 gtttagttat acataaattg gtaagaggtg taaactaatg aagattaata aattaccaca
      301 tgcagaacta aaactaatga agtatatttg gggagtagat gatgtattag cctcaagaga
      361 tatcatagaa gacatgaagt tgaaatacga ttggaaaaag agcacaacat tgacattttt
      421 aaaaaattta gtagataagg gctttttaac tactgataag gtagatagat gtacgcatta
      481 tactatagct ataaaagaga aagattactt aaaagttgag acaaagagtt tttttagttt
      541 tatgcataac aattcattta agagttttat ttcagcacta catgatgatg aagttttaga
      601 tagtaagagc ttggacaaat tagaagaata ctttaaaaat ttgaaagaag aagatattga
      661 tgactaataa agctatcagt atctttttag tttgagacaa ttgagagtag cgtttggatt
      721 taatgttagt tttatgtgat ggtagaacat tatataaaga aaagtgatta tttccttagt
      781 gtttgatagt aaaaaatata gagaataata ccaattaaaa tttaaagata tatgaaatac
      841 tacaatagct taaatcatgt aaatatgata aagatattga aattataaaa ggaatataat
      901 tttagaagaa atagttgaca gataaattac cttactatat tattgtatta ataaaataat
      961 acaataatat agtaaggagg taataaatga aatctagaaa acataatatt acaaaaggat
     1021 tatttatagt ttacataatt attttaacat ggataatact atttaagttg caatttgata
     1081 tctcatctct tgaaaccatg aatcttagaa gcataaactt aatacctttt gctgggtcac
     1141 ttataattaa taatagagta gatatatcag agattatatt aaatgtggct atatttgtac
     1201 catttgggat atatgtgtgt atgctaaaag aagaatggag ctttataaaa aaagttatac
     1261 ctatttttat aactagtttg gtatttgaaa cacttcaata tatatttgca ctaggtgcaa
     1321 gtgatataac ggatttgata ggaaacacac taggaggaat cataggaata gctgttttta
     1381 tgctattatc gaaaatattt aagaataata ccataaaaat tatcaatgta ttggcattga
     1441 ttgtgacaat tattgttgta ttatttttag gattagttat ttttgcaaac ttatagaaat
     1501 aagtatatat gtttagctta aaatagaacg taagatacag ttacatataa aattatttac
     1561 acataaaaag cacctataca ggtgctttcc taaattatta aagaattatt gtatcttgaa
     1621 actcttgtat gttcaattct tgattttctc ttgttttttc taataaatct aacgcacaat
     1681 ttatacaaac tttaatttct gcattggtat ttttctcata ataagttata tatttatttc
     1741 tatatttatc tatttctttt ccacaacgac tacacattac aattacgctc atatcttagt
     1801 tcctccatct ctaattattc ttaatatatt caatagtatc acttttctga aaataatgat
     1861 tgttaaaact gtatcaaatt tagatttact ttttattata atgcatttta ataaaaaaat
     1921 aaaggttatg ggtaaaatat ttatagaaaa aagtatatta ttgaatagat tataaaattt
     1981 tattattttt tagcagtgtt aaatacacat taatatctat aaagtgacaa aataaaaaat
     2041 actatttaaa tagatattaa aaaattgata ccaagtattt atttgctata tgaataacaa
     2101 tttatttagg aactttactt taacactgta taataataaa gtaattgcta aaaacgtttg
     2161 atgatttgga tgtattttta gaaattagaa aaatatatac ttactgacta atgataatct
     2221 tatatgtatt ttagtttgag tgatttaaga aaagtgtttt gaatggggat tattttatag
     2281 agtaaataaa tatataatag tagaaaatta catataaaga gtagtgttta tttcattacc
     2341 ttctttatct gttccgatag ggtcttgtag agatacttga gttttatttt ttttgttaga
     2401 tctaatattc attaaaatct cattttcaat acatctagaa gcatatgttg ctaatcgagt
     2461 tcctttatct atgttataag tttctatagc tttaattaat cctattgtac ctatggatat
     2521 taaatcatcc tgatcttccg ttgaattatt atatttcttt gctatataag ctactaatct
     2581 catgtttctt tcaattaatg tatcttttgc acttttatcg ttttctattt taaatttagt
     2641 taaatactca atctcttctt caggggttaa gggtttttca aaagatttaa gagctgccaa
     2701 taggtcaccc ccttttcaac ggtcacttta aattatatga aggagactta tccaagttga
     2761 ctgttatcta ataaaataat atgcatattt ttagaattta aaacatatat ttgcaaactt
     2821 ttgaatggaa tatgacataa agagtgggaa tttaaattta agtttttgtt gtatatatat
     2881 gaaataaggc gaagaaatta ttgatttata aagtataaat tggaattgag gtgtcaataa
     2941 atataaaagg aaatagtatt tatatatgtt ttggtgttga agtaaaagat taatgcaaag
     3001 cattagagtc tataaaaata tgaatatagg aggtgtaatt ttacaatact taaaaaagta
     3061 aatgtaatta attgtttgta taaagttgat tacaagcaaa agtatcagtc atagttaata
     3121 ctgttaaggg tgaaggtggt gtgttaattt atatatgtat gggaagaaat tttgattaca
     3181 atgaaaaaac ttacaaaaga tatttatgaa aaaacttata gttaaatgtt tatatataaa
     3241 atattattta ggggttgttt ttattattga aaataagaaa gagtggtttt atatcaattg
     3301 aatgtataat aagtattgct atattatatg tggctgttta tttagtttct acatcattgt
     3361 ataattgtta tagttttatc agtagaaata tatctgacag agaaatgtta agtacagcaa
     3421 aaaaatatat agaagatgag aagtatagaa tacaaaatag taagtatgag ttaattgaag
     3481 ataagataga aaaaaattac ataaatggat atgaaattaa cagtaaaata gagcaaattt
     3541 tagattatta tcaatgctat gaaataaata tagagataaa aaatgaattt aaaaaactga
     3601 ggtttaatag ctatgttact agaaaataaa ggctctatat taataataac attgataata
     3661 ttttctatta taagtactgt gtgcattatg tgtataggtt taatttatac acataataat
     3721 atgtttgagt taggatacaa ggacattcaa ctaaaagaaa tttctttaag tggaatagaa
     3781 atatcagtaa gtaatgtact ttcttgtgtt gaggaagcta ttgatgtatc taataatgaa
     3841 gacgaattta gagaatattt cttaggaaat aatatgattg aatgtataaa aaaaataaaa
     3901 gatacatctt atagtagttt agaagaactt tctttaaaag tagaaaataa tactatttat
     3961 gacagaggag atttttttga atttgatata gaaagtaatg ttagagaaaa agaattttta
     4021 aaagcaataa aagtaagagt gaaaatcaaa aatccatgga taggaattga cattgaagat
     4081 tatatggata aatctaataa caataaaatt gatgacaaaa cattcaataa ttataaagca
     4141 tctgaaaata atgaaattct aaatcaattt aaaaatgaaa gtgaaaatat aaggaatcaa
     4201 gaggttggtg gatttacaga agaagatgaa gaagatgaag aatatgaaga agaacttaaa
     4261 caaaacataa ttgaaaatat aaagaagaat tttgatgaaa aaaacctagt acaggtatat
     4321 aagtataggg gtgtataact ttgaaaaaag aaggaatgtg actgtaatag aattaatagt
     4381 atctatcagt ataatactct tgatagttac attatctttt ccaaaagata atcttgaaaa
     4441 tcataaaata aatttatttg cacgtcaact ttgttcagat ataaggtatg ttaggcgaat
     4501 taatatgttt agcaactaca atacatatat atattatata aatcaaggta aacacgaagg
     4561 ttatgtattg agaaaagatg gtaaaaacat taaatcaata atgctaccta aaaatgcaaa
     4621 aatagctagg agtattgaaa taataaagtt taaatctgat gggtcgcctc aaaaggcgtc
     4681 tacaatagag atatataata atagattaag aaaaactata acaataacac ctgtaagtgg
     4741 aagagtactt ctgaaagagg gaaaatatga aacataaata tggttacttg cttttggaaa
     4801 gtgtcgtatc attgtcttca atggtgataa ttatactagt tttatattct atatttttgt
     4861 ctacaataaa cttaaagtta aaagtagaag ataagataga actacaacaa caaagtcttg
     4921 aaatcataaa atctatggaa ggaattatta gcaattctat gggaataatg aatgtatcta
     4981 attatgaaga aacatttaaa aagacaacat ctataaaatg tagatattta gatgaaaata
     5041 ataatgaaga aggcataagt aataaagaaa ttatattgaa tgaaagacga aataagttat
     5101 ttgtaaattc tttaaatggc gaaagtagtc aagcaggtgg ttatgaaatt ggagattatg
     5161 tagatgagat gtatgtatca attactaata atggtcaata tgttaatatt aaattgaaat
     5221 tatcaaaacg tagtcaaaaa tatgagactg atttcaaaat aaaagtatgg aattttagtg
     5281 aaagtatata gaaatacata aatttaagag aaagaagtga catcaataag tcatataaaa
     5341 tataattatt gagaactata taactaaata atatcaatat gtaaagtgta tagattaaga
     5401 atatagagga taataataaa aatatagaat aagtaatttg ccaaatactt gtttatattg
     5461 tataacttat gatattatga tattagtaaa aatttgtaat cctgacttga cagaattcaa
     5521 gtaagagata taattttaaa ggcatagtaa tgtaaaattt actaaaaaat aagaaattta
     5581 ttttaatatg gaggaacaaa aaatggtatc agcaggtgat tttagaaaag gtgttacatt
     5641 tgaaaaagat ggacaaccat gtttagtagt tgattttcaa cacgttaagc caggtaaagg
     5701 agctgctttc gttagaacta aatacaaaaa cttaaaaaca ggagctataa gagaagaaag
     5761 tttcaatcca agtgaaaaat tccctaaagc tgttatagat acaagacaaa tgcaatatct
     5821 atacaatgat ggtgagttat attattttat ggatcaagaa aattttgaac aaataccatt
     5881 aaactatgag caagttgaag atgcaattaa gttcttaaaa gaaaatgaag ttgctacaat
     5941 aagattttac caaggacaac cattccaagt ggaagcgcca aactttgcag agctagaagt
     6001 tacagataca gagccaggta taaaaggtga tacagcaagt aatgtaacta aagcagctac
     6061 agttgaaact ggagcagttg ttcaagttcc attatttata aatactggag ataaagtaaa
     6121 gatagatact agaacaggtg aatatttatc aagagtataa aaatttatgt atataaaagc
     6181 ttatatgtct taataatata agatatatga gcttttagtt tatatataaa aaagaaagcg
     6241 aggggtgtta catgaaacat ttatatgaag aagttgcata cttaaaaggc ctagcagaag
     6301 gactagaaat aagtgctgaa agtaaagaag ggaaaatgat acataaaata gttgatgcat
     6361 tagaagtatt tgcagatgct attgtaacat tggatgaaga acaagaagaa cttcaagatt
     6421 ttgttgaatc tatagatgaa gatttagcag atttagaaga agatattgct gacatggaag
     6481 aagatcttta tgaagaagat gacgatgagg atgatgagga cttcagctat atagaaatgg
     6541 aatgcccaaa ttgtggagag ttagtagaaa tagacgaaga tttgttatat gatgatgaag
     6601 tagatgttgt ttgtcctgat tgtaaggctg tgatattatc atcagaagat gattgtgatg
     6661 atgattgtac atgtggtggt tgttcaagtt gtgatgatag agagtaaaaa ttcataagaa
     6721 ttaaaactgc ctatgatgcc tatgagatat tttgcttcat aggtagtttt atttttatga
     6781 ggaagggtat tatgtatttt ggttttgcaa tacttggaca aaaatagtac actagaattt
     6841 atagaatagg attttggagg gatgtaaata tgaaaataag taaaaaatta ctagataata
     6901 tacaaagatt tgaaaatgtt ataaattata aatttaaaaa taaagaatat atactagaag
     6961 ctcttactca tagttcatat tctaatgaaa ataaaaaata taattttaac gaaagattgg
     7021 aatttttagg ggattcggtt ttaggcatag tgataagtga ttatttattt aatgaagaag
     7081 ctaatctgcc cgaaggggaa ctaactaaac ttagagcaaa tatagtttgt gaagattcat
     7141 taagtgaagt agctaatgat ataaatttag gtattcacat gttattaggt agaggagaag
     7201 aagcaacagg aggaagacat aggacttcaa tattagcaga cgcatttgaa gctgtaatag
     7261 ctgctatata tcttgatgga ggttttgaaa gtgcaagaca gtttatactt catcatatgg
     7321 aaaatataat ttatgattca agaaaaggaa atatatttag agactacaaa acgcatcttc
     7381 aagaggtgtt acaagggaat ggagaaaata atatctggta caggcttata gaagaaaaag
     7441 gaccagacca taataaaaga tttgtaatgg aagttggaat taatgacgat gtacttggta
     7501 taggagaagg caagagtaaa aaagaagctg aacagttagc tgctaaaata gctttaaaga
     7561 aaaaattatg ggaaaaataa atataatatg taaaaatata aaaagaaata tttatattag
     7621 aaggatgttg tagatgaaaa agagaattat acctatattt gttcctcaca aaggatgtcc
     7681 tcatgattgc atattttgta atcaaaaaaa aataacaggt gtgagtactg atgttactag
     7741 tgaagatgca agaaatataa ttgaggaatg tttagagact atagataaag atgcagatgt
     7801 agaaatagca ttttttggtg gtagctttac tgctatagat attgatatac aaaaaagttt
     7861 attatcagtt gctaaagaat atgtagaaaa aggtcttgta aaagatatta gaatgtctac
     7921 aagaccagat tgtattgatg aagatatatt aagtatgtta aaagaatata agacaagtat
     7981 aattgaacta ggagtacaat ccttagatga aaaagtatta ttagatagta taagaggtca
     8041 tcaatctgaa attgtataca agagttcaaa gatgataaaa aatagtggaa tcaaacttgg
     8101 attacagatg atgattggtc ttccagctga cacagaagaa aagtgtatat ttacagcaaa
     8161 aaaatttgta gagctaaaac cagattgtgt tagagtctat ccaactttgg tagtaaaaga
     8221 tacaggtctt gaaaagttaa tggaacaaaa taaatataat ccatttactc ttgaagagag
     8281 tgtaaatata gtaaaaaaag ttcttgtact gttttatgtt aataatatca atgtaataag
     8341 agttgggctt caagctactg atgatataca aattggaaaa gctgttttag caggaccata
     8401 tcatcctgca tttagagagt tggtagaagc agatatgata aaagattatt tagaatttgt
     8461 tattttgcaa aataaaaata taaagcaaat gttggtcaaa tctaataaaa agaatatttc
     8521 taaaatcata ggaaataaaa aaacaaatgt taaatatatg gaagaaaaat ttggtgtgct
     8581 tttaaaaaca caagaatcag atttagatat aaatcaatta gaaattgtgt tagatgggaa
     8641 aagtttaatt agtgctaata tgagagacat tcatagaaaa ttgtatgaca tttatgacct
     8701 ttagttttaa taatgaaggg agagaaaaga tttgtattta aaaagactag agttaaaggg
     8761 atttaaatcc tttccagtaa aaacagatat tatttttaaa gaaggaataa cagccatagt
     8821 aggaccaaat gggagtggaa aaagtaatat atctgatgct gtaagatggg tattaggaga
     8881 acagagtatt aagagtctta gaggtgataa actcgaagat gtaatatttg caggtacaga
     8941 tacaaaaaaa cctatgaatt attgtgaagt ggctcttact attgataatt ctgaaaatca
     9001 attggaatta gattttacag aagtaactat aagaagaagg gcttatagaa atggtgaaag
     9061 tgaatttttt ctaaataata aaagttgtag attaaaagat ataaaagaag tctttttaga
     9121 tactggtatt ggaaaagatg gttattcaat catagaacaa ggaaaagtag atgaaatatt
     9181 aagtaataat cctttaagca gaagaaaagt ttttgatgaa gcttgtggca tatcaaaata
     9241 tagatataaa aaacaggaag cagaaaggaa tttaagtaat acaaaggaaa atttagaaag
     9301 aatagatgat gtatatatag aaattgaaaa tcaattaaag cctcttttta atcaacagac
     9361 aaaggcaaaa aagtacttgg aaataagtga aaaattaaag acacttgaag taaatagctt
     9421 tataagagaa attgaaggaa tagaaaaaga attaagtgag gttaatgaac atcgtaaggt
     9481 tattgaaaag gagctcaatg aaaaagaaga acaaaaaaat gttgtagaga aaaagcaaga
     9541 agatattaat aaagaggtag aggtattaca agatgtaatt gaaaaatctg tagattatat
     9601 aaattcaatt aaaggagtta tatcaaaaaa agagtcccaa ataaatttaa ttaaggaaag
     9661 aataagaaat tttacgaatg aaattagtag aaaaaattta gaaataaagg atataaaaga
     9721 gaagctaaat gaaaataagc aatacataaa agaattagaa agcaataaat tatcaggtag
     9781 tgaagaacta tctaccttgc aggaaaatat aaaagtattg gaaggaagta aagataaaca
     9841 aaaaattaag ttagaatccc taaataatga gatagaatta ttgaaagaaa gtataattga
     9901 tatattaaat aagaaacaag agtttagtaa taagctgtct actttaaacg caaataaaga
     9961 aaatatgaat atcagagatg aaaatataaa ttcagagata acagagttaa acaaaaatat
    10021 tgaaataaaa tcatctgaat tagatactat aaataaagaa tttaatatgc aaaatgaaaa
    10081 tttaaagaat gtaaataata gacataaaga attatcaatt aatttgcagg attcaattag
    10141 tgaacacaat aaactagaag atgaaataca gaaaagtaaa tataatttaa atggatataa
    10201 ttcaaagtta aatgtctata tagatatgga aaatcattat gaaggattta atagaggagt
    10261 aaaagaagta ctaaaaaata aaaatttaaa aggagttcat ggagcattag gacagattat
    10321 aaatgtacct gaaaagtatg agaaatctat agaagcagct cttggtgctt atatgcaaaa
    10381 tataataact gataatgagt ttagtgctaa gtttgcaata aactatctaa aacagaataa
    10441 tttaggtaga gtaacatttc ttccattaaa tataattaaa tcaaataaaa taagtctagg
    10501 aaatttaaaa gcaaatacta agttcatagg aatagcaagt gatttaatta catttgatga
    10561 aaagtataga aatataattg aaaatatact tggaagaaca atacttataa ataatataga
    10621 tgagggcata aaatttgcaa aagaaactgg tcataggttt aaaatagtaa ctttagatgg
    10681 tgaaatctta aatccaggag gttctttgac tgggggaagt ctaaaaacta atgggaatat
    10741 actatcgaga aaaagataca ttaatgaata tacagaaaag ataagtaata tcaagaatga
    10801 aatttcacat ctagaattaa aaagagaatc tttagacaaa gatgtgaaaa atatcaaaaa
    10861 tgaaattgat tcacatgaaa gtaaaataaa agatttagaa aaaagtataa taataaaaag
    10921 tacaagtata aagaatgttg agtctgaaat tgaatcgtta aaaggtagta ttactaaatt
    10981 agaaaatgag aagaatgatt taaattctaa cctaaattat acacttgaaa aaagtgatga
    11041 tgttagaaaa gatatggaag agttagatga tttatacaat aaaaataaag aaaaaattga
    11101 tgcattgaat gaggaaataa aaagatacaa tgatttatat gataaagaaa aatctgaatt
    11161 tgatgaattg aacttaagtt tagtgaagaa aacagaagtt tacaatagta tagttagaga
    11221 tataaaaaga atatctggtg aaaattgtga gctagaagaa aaaaataaac aattagaaga
    11281 gtcattaaat tatgaagaac atgaaataat taaattacaa gattctatac tcactgaaga
    11341 aaaagaaaaa gaaaatttaa caaaacaact aggggatagt aatagaaatc ttgaaactag
    11401 aaaaatagca aaagatgatt taaaaaatag ttttgatgaa attaataaag aattaaaaac
    11461 tatagataga cagcatatag aacttaaaga aagtttattt aaagttggtg gaagattaga
    11521 aagattaaaa actagtcaag acacatatat aaataagttg tttgagcaat atgatatgac
    11581 cttagtacaa gcattggaaa ttaaagatga agatttggat atagatagaa aattcttaga
    11641 aagtctaaag agagaaataa gaagtcttgg aaatataaat atagactcta taaaggaata
    11701 tgaggaaata aaagaaagat acgattttta tagcgaacaa aagcaagatt tagaagagtc
    11761 tatggaagag atagaaaaac ttatacatac tttagaagaa aatatgaaat ctgaatttga
    11821 aattaagttt gaagaaataa gtaaaaattt taaatatgta tataagagat tatttggtgg
    11881 aggttgtgga gaattaacta ttttagataa agaaaattta ttagaaagtg atatactaat
    11941 aacagctcaa cccccaggta aaaaaatgaa aaatttaaac ctattatctg gtggagagaa
    12001 agctttaacg gcaataagta tattatttgc tatattgatt acaaagccaa caccattttg
    12061 tatattagat gagattgaag cgccacttga tgacgcaaat atatttagat ttggagaatt
    12121 tttgaaggat ttatctaaag agactcaatt tatatcagta actcatagga gaggaacaat
    12181 ggaagctgct gattatatct acggagttac aatgcaagaa aaagccattt caaaagttat
    12241 tagtttaaaa ttaaaagaag ctcaggaaat aacagatatt atataactta gattgacata
    12301 ggaggaataa cagtgttaaa aaaattattt ggttttggaa aagacaagga aaaggaaata
    12361 gaaaaaaaag atgctgaaga agaaatagaa gttgaagaca gtgttgataa tttagaaaac
    12421 ttggaagaaa ctattttttc aggacttgaa gaagaagtga tagataaagt ggaagatatt
    12481 gaagaaaaaa atgaggaaag tgtcaataat gaaggcactg aagaaatcga aaactttgaa
    12541 aaaatagaag ttgagatgga tagtaatgga aaagaagtag aaaatatttc aaataatgat
    12601 tctcaagaag agataatcga agaattagaa aattatgatg aaattgagtc taaagagata
    12661 gaagataaag aagataagaa agttaacttg tttgaaagac taaaacaagg attgacaaaa
    12721 gcaaagcaag gaataactga tagaatagat gaagttttaa aatcatatac aaaaatagat
    12781 gaagaattac ttgaagattt agaggaaatt ttaataacag cagatgttgg tgtaaataca
    12841 actatggata taattgaaag actaagagat aaaataaagc aaaaaggtat tactgaacca
    12901 ataaaggtaa gagaagaact taaatctata gttgaagata ttcttacaaa tgaaaactct
    12961 acactagata tagaaccagc accatgtata atattaatgg tgggtgtaaa tggggtcggt
    13021 aagactacta caataggtaa actagcaaat agatacaaaa aagatggtaa aaaagtttta
    13081 ttagcagcag cagatacatt tagagcagca gcgacagagc aattagaaat ttgggcaaat
    13141 agaaccaatg tagacataat aaaacatcaa gagggagcag accctggagc tgtagtattt
    13201 gatgctataa aagctgcaaa agctagaaaa acagatgtat taatatgtga tacagcagga
    13261 agattacaca ataaggctaa tcttatgaat gaacttggaa aagtatttaa aatagtagat
    13321 agagaatttc cagaagcaaa acgtgaagta cttcttgtgg tggatgctac aacaggtcaa
    13381 aatgcagttg ttcaagcaaa gacatttaaa gaagttgcag atataacagg tatagtactt
    13441 acaaaacttg atggaactgc aaaaggtgga gtagtccttg cagtaaaatc agaagtagat
    13501 gtacctgtaa aacttattgg agttggagaa agtgtagaag acctacaaga tttcaatgca
    13561 aaatcatttt cagatgcatt atttggtaac taatgttctt ttaaaaataa tggttgacaa
    13621 gagtgttgtt atgatataaa atacaatagt gtaaagtaaa taacctttac agtatactgc
    13681 taggaagtgt aagatatgaa tatagaaaaa atggtcgaaa ttggattgtt atttgaacag
    13741 tataaagaat tattaactga caagcagaaa gaaatagttg ctctatacta tgaagaagat
    13801 tattctttag gtgaaattag tgaaaatctg aatgtatcaa gacaaggtgt ttatgatacc
    13861 ttaaagcgtt cagaaaaaat actaagagat tatgaagaaa agttacactt agtatcaaag
    13921 attcaagagc aggaaaaaaa tattaagatt ataaaagata aaattattga cattaaagaa
    13981 gatttattgc acaatagaga ttgtgctaat ttaatcccta agctagaaaa tatagaagat
    14041 gtatgtaggg agatgataaa atgatatttg aaggattgtc tgataaacta caaggggcat
    14101 ttagtaagtt aaaatctaaa ggaaaactta cagaagtaga tgtaaaaaat gctatgagag
    14161 aagttaaact tgctcttctt gaggcagatg ttaactttaa agtagttaaa gatttcataa
    14221 aaaaagttca agagagatgt gttgggcaag aagttatgca aagcttaact ccagctcagc
    14281 atgtaatcaa aattgtaaat gaagagctta caagtttaat gggagatgta caaagtaaag
    14341 taatgatttc ctcaaagcct cctacaattt taatgatggt tggattgcaa ggtgcaggta
    14401 agactactac agcaggaaaa cttggaggat attttaaaaa gcaaggtaaa aaacctctat
    14461 tagtagcttg tgatatttat agaccagcag ctataaagca acttcaagtt gttggagaaa
    14521 aattggatat acctgtattc aatatgggag ataaagaaaa tccaataaat attgcgaaag
    14581 caggtttaag ccatgcgatt aaaaatgcta atgatttagt tattatagat acagctggta
    14641 gacttcatat agatgaagta cttatggatg agttaaagtc tattaaatca gaagttaagc
    14701 cacatgagat acttttggtt gtagattcta tgacaggtca agatgctgta aatgttgcag
    14761 aaagcttcaa tgaggcactt ggtgttgatg gagtagtatt aactaaattg gatggagata
    14821 ctagaggtgg tgctgcactt tcaataagag cagttacaca aaagcctata aaatttatgg
    14881 ggatgggaga aaagctagat gatatagaac ctttccaccc agatagaatg gcatcaagaa
    14941 tattaggtat gggagatgtc ttaagtttaa tagaaaaagc acaagaaaat atagacttag
    15001 agaaagctaa agaattagag caaaaaatta aaaaacaaga gcttgatttt gaagatttct
    15061 tacaacaaat ggaacaaata caaaatatgg gacctcttga caagatactt ggtatgatac
    15121 ctggtatggg aaatgtaaaa gaccaacttg gagatgtaga tttgaatggc aaagaaatga
    15181 agagaacaaa agccataatt cagtcaatga ctacatatga gagaagaaac ccaggagtat
    15241 taaatgcttc aagaaagaaa agaatagcta aaggcagtgg aactagtgta caagatgtaa
    15301 atagacttat aaaacaactt aatgaaatga aaaaaatgat gaagatgttt gctggttcac
    15361 aaaagagtat gaagaaaagg ggcggcttag gcggtttacc tttttttaaa taaaatataa
    15421 aaaagtaaaa attattcgga ggtgactgta atggcagtta aaataagatt aaaaagaatg
    15481 ggagctaaca aaaaaccttt ctacagaata gtagtagctg attcaagagc tccaagagat
    15541 ggaaaattta tagaagaaat aggatactat aatccaattt ctgaacctaa acaagtaaga
    15601 ataaatgatg aaaaagctat aaaatggtta gctactggtg ctcagccaac agaagtagtt
    15661 aaaaaattac ttgtaaaaaa cggagtaata gaaaaattcg aagcttctaa acaagcaaaa
    15721 taattttttc ttggcaatta gtttaagtaa gggctcattg ctaaggttac tttaggagat
    15781 gaaatatatg aaagagctag ttgtagatat agctaaggct ctagttgata atcctgactc
    15841 agttgttgtt gaggaatttg aagataatga tggtatcgtc ttaaagctta cagttgctca
    15901 agaggatatg ggtaaggtta ttgggaagca gggaagaata gctaaagcta taagaactgt
    15961 cgtaagatct gttgcaaata gagaaaatat aaaagtttct cttgagatag tataaaatag
    16021 gaggattagg tataatgcct agtccttttt atataaatgc gtagtttaag attttatgat
    16081 gatatgacca cataagatta aattttttaa gaaggtgata acatgaaaga aaaattaact
    16141 cattttaagg taggtcaaat agtaaataca caaggtttaa aaggtgaagt aagagtttat
    16201 ccgcttactg atgatataga gaggtttgat gaattaaaag atttctatct gggaaaagat
    16261 ttaaataata aattggctgt tgaaaaagta agatacaaag gttctatggt tataatgaag
    16321 ataaaaggca tagacagcat agagaaagca gaaaaactaa aaaataaatt tatgtatgta
    16381 gctagagaag atagcagaga gcttgaagaa ggcgaatttt ttatagcaga tatgattgga
    16441 atggaagttt taactgtaga tggaaaatat gtaggaatac tagaagatgt tcttcaatac
    16501 tcagcaaatg atgtctatgt agtaaaaggt gaggaagata aagaatttat gataccagct
    16561 ataaaaaaat ttgtacctac aatagatatt gatgaaagaa aaatgattat agaccctatt
    16621 aagggaatga tagattaggt ggtaatatga gatttcatat aatgacactt tttccagaaa
    16681 tatttaattc gtacatggat gaaagtataa tgaagagagc agttgaaaaa ggtataattg
    16741 aggttcatat atataatata agggattttt ctaataataa acataaaaaa gtagatgatt
    16801 atccatttgg aggaggagcg gggatggtaa tgactcctca acctatatat gacacatata
    16861 agcatataat aacaactcat aatataaata acccaagtgt aatttatctt actccaaaag
    16921 gtaaggtata caatcaatct atggcaaagc agatgtcttt aaaagaagat ataatactac
    16981 tatgtggtca ttatgaagga atagatgaga gaatcattga tttaatagtt actgatgaaa
    17041 tttcaattgg agattatgta ttaactgggg gagagctccc agcacttata atgatagatt
    17101 ctatatcgag attaatacca ggtgtattaa accaagagga atcatttgaa gaagaatcat
    17161 ttaaagataa cttattggaa tatcctcatt acactagacc tagagatttt gaaggattaa
    17221 aagtaccaga agtgctttta tcagggaatc ataagaagat agatgagtgg agaagagaag
    17281 aatctataag gataactaaa gaaagacgat ttgatttata taaaaagtct aatgaaaaat
    17341 aaaaatataa tgaaaaatta atatatatgt atacaataaa gtacctataa atggaattaa
    17401 aaacataaaa gtgcttgtaa taactattga agtatagtat aatataaaat gttgaaaata
    17461 cgggcgttcc tctgtttaca ctggtcgggt agttaagaac gtctatgata tctaggagga
    17521 agaaagatga atgaaatgct aagagcaatt gagcaagaac aattaaaaaa tgaagttcct
    17581 aattttggac ctggggacac agttaaagta cacgttagaa ttatagaagg aaaaagagaa
    17641 agaatacaag tattcgaagg tgtagtatta aagagacaag gtggaggagc aagagaaact
    17701 ttcacagtta gaaaaatgtc tttcaatgtt ggtgtagaaa gaactttccc agttcactct
    17761 ccaaaaatag aaaaaataga agttactaga aaaggtaaag taagaagagc taaactaaac
    17821 tacttaagag gtagagtagg taaagctgct aagataaaag aagctagaaa taaataatta
    17881 aaaactttac ttataaatgg ggggctgatt tatcagtcct ctttctattt taatgaaaat
    17941 tacagcaaat aattatacta gaaataaata gaaatatttg ttgaaaatat acattattta
    18001 tctatgaatt tatagccttt aaaatgaaaa ataaaattgg taaatattgc attatatttt
    18061 gtaacaatat taaaaataag agaacagtat tatgtaaagt atgacgttaa aaagatgaca
    18121 atattatagt ttgttaagat agatttttta agtggaatta ggatataata atataatatt
    18181 aataaggagt gatacatgtg tcaaatgaat acgaagagta tcttatgaat gacaatctac
    18241 atataaactg gtatccaggt catatgaaaa aaactaagga gttagtaaaa aataacttaa
    18301 aattgattga tgtagtaatt gaacttttgg atgctagaat cccgtttagt agtaaaaatc
    18361 cagacataga caggcttgta ggagataagc caagagttgt cgtacttaat aagagtgata
    18421 tggcagatag ggataaattg aatcaatgga ttgaatacta taagaaaatt aatatcaaag
    18481 ctataccagt agatacaata aaaggcgttg gtataaataa gataatcgaa gaatgtaaaa
    18541 atgtaactag agaaaaaatg agttctttaa aagacaaagg gagaaaagaa agagctatac
    18601 gaataatgat agttggagtt ccaaacgttg gtaaatcgtc tcttataaac aaattaacag
    18661 gtagaaaaag cactcaaact ggagataagc caggagtaac gaaagggaaa caatgggtta
    18721 gattaaaggg aaatcttgaa cttttagata cacctggaat actttggcct aagtttgaag
    18781 accaagaagt tgcattaaat ttagcattta gtagagctat aaaggatgag attttagata
    18841 ctgaaacttt ggctttaaga cttatagaga aacttatgaa aatagaacct gagaagttga
    18901 aagccagata taagttagat tgtttaggag aaactccaat tgaaactatg gatatgattg
    18961 gccataaaag agggtttata acaggtaaaa aagaactaga ttatacacgc atagccacaa
    19021 ctgtattaaa tgaatttaga gatggaaaaa taggaaatat aacattggaa gttccagaaa
    19081 acgttaaaag atagatttta aaacaaaatc aaaaatttaa tgttaaaaat ttaaaaaagc
    19141 cttttagcaa aggctttttt atttttttga aatatagaca aatatctcca tataaaagta
    19201 taaattaggt tagaaaacct ttaaaaatat taatttaaga caaatatacc taatattttg
    19261 aaaattaaaa tgagtgtgat tatttaaaat tttagcatat tgacttgctt gtttcgtata
    19321 atatataata agcacaaata aatacaatat attaaaaatt taatttattt aattttatta
    19381 atttaataat aagttcttat tgtttaattc aacttactta tgcaagcgta aacaatcgag
    19441 acattttatt aatttaataa ggttaaaaag ggggatttta taatgggtaa gaccaaggat
    19501 gttatagtat ttggatttgc gttatttgca atgttctttg gagcaggtaa cttaatattt
    19561 ccaccttact tgggaataat tacaggtcca gaatggttaa ttgccttctt aggatttacg
    19621 tttgctgatg ctggattggc acttctagca gtaatggcta cagctaaatt cgatggaaac
    19681 gtagttgaaa tgtttaaaag atgtggtatg aagttaggga ttcttatagg ttgtgcagat
    19741 attttatgta taggcccatt cttagctata ccaagaacag gtgcaacaac ttatgaaatg
    19801 ggtataatgc ctttgtttgg aacttcaatt ccagtgttat tattctgtat actttttttt
    19861 gcgatttcat atgtactaac aataagacct tctaaggtcg tagatatagt tggacagttt
    19921 ttaactccag ctcttctaat agctttagca tttataatta taaaaggtat tatatcacct
    19981 cttggagata tagtagataa acctatgata cctaatgtat ttgcagaagg tataggtcaa
    20041 ggatatcaga caatggatgc ttttgcagca atagcacttg catcagtgct aatagtatct
    20101 ttaaatgata aaggatattc tactattagt gacaagttga aaatgattgg taaggcgggt
    20161 gttcttgctt gtggaggatt agctctagtt tatggaggat tatgtttcct tggggcaact
    20221 gtatcaacaa tgtatggaac agatgcagta caatcacaag taatagtaaa tataactgaa
    20281 ggattgcttg gaaatgttgg gaaagcgatt ttagcagtag tagtatcatt agcatgttta
    20341 actacatcta taggtcttac atctgctaca ggtcaatatt tctctagact tacaaaaggt
    20401 aaattgagtt atgaaaaaat agtattagct gtatctgtat tcagtgcagt agtagcatct
    20461 tttggtgttg gaactataat aaagatagca tctcctatac taagtatagt ttatccacca
    20521 tcaattgttt taataatttt agctttcttc aatgaaaaaa ttaagaatga taatgtatac
    20581 aaaggagcag tatatatgtc attgcttgta agtatactaa cagttatatc tagttatgga
    20641 gtagctgttc cagtagtaaa ttctttacct cttaattcat taggatttaa ctgggtggtg
    20701 ccagttataa tagctggaat aattggtaat tttataccat caaagagtca atctaataca
    20761 cttggaacaa actaagtttt gtttaattaa aatataatca attgtaaata aatgagttaa
    20821 ctaaaagtaa aaggagttat ttgtacaaat aactcctttt a
//
LOCUS       DAEQCW010000066        20850 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.066, whole genome shotgun sequence.
ACCESSION   DAEQCW010000066 DAEQCW010000000
VERSION     DAEQCW010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20850)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20850)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20850
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.066"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..842)
                     /locus_tag="KRO40_002375"
     CDS             complement(<1..842)
                     /locus_tag="KRO40_002375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2093192.1"
                     /translation="MIIQQIYNNNVVLVLDENIKKELILTGCGIGFQKKKGQEIDKSK
                     IERTFVIQDESFLDKISKLASQVDEKFFEVSTEIIAYAEENLNTKLYEYIYVALTDHI
                     AFAIKRYHENITIKNDLLHEIKRIHKKEYEIGKWAVDYINKEFDVKFPVDEAGFIAMH
                     IVNSNYKGSSKESLLITKIVKDILNIIRYYYRVEFKEDDINYDRLLTHLKFFAKRLVK
                     KEKINDTNNEIIDIIKVKYEKDYDCAYKIKTHVEKNYDYYVSQDELLYLTLHIKRVIS
                     VLNL"
     gene            complement(1103..3145)
                     /locus_tag="KRO40_002376"
     CDS             complement(1103..3145)
                     /locus_tag="KRO40_002376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:proton antiporter"
                     /protein_id="HBH2093193.1"
                     /translation="MSILVTLLGLLVCTTISTVFSKKWSNIPLAIYQIVLGIILSILP
                     FKFSFSFNPEIFVICIIAPLLFSEGQNVSRKELLELRKPILLLAFGLVLITVFAGGIF
                     IHFLIPGMPLSVSFALAAVISPTDLVAVKSITQGLNFPKNMMSILEGESLLNDAAGVV
                     AFKVAVLATVTGVFSIEEAGIQFMITAFGGIIVGSILGYIIIKIRLSLHKWNLEEIPM
                     VIVIQIMTPLFVYFVAEEIGVSGILAVVMAGIAHGIEKEHLQNTTTKLRIISDNTWYV
                     LEYVLNGFVFTLLGFLLPSIYTGLSSKNENMALELTFISTLIVLILFVIRFIWVYLWH
                     NSFIKPKKNPLNNFFVGFLGFKDEEVVKESISKCKYSLIVATCGVHGTFTLATALSIP
                     FYLADKDVFPMRDTVLFISSEVILISLVLATVLLPRLLKNNVQESEPLLSDKEAYKLI
                     LKEAILKLSNEKAQEVQPVIHDLNEQLVDSEKGILNTPDNKLISMMIAEADQQGLLAV
                     LKLLEDGKISDRAFKLYRFYITKSRKSVQKSIFKIVKLKISMWIINRKVKKEVKEKIT
                     KIVSENKEIIKEFHHAYALSTKTAISFINKNTDEDNRHEALIAIRFYNRYLNWITRKI
                     QNDDKFEARVEYYRVMAIQSQRDSVQQLVETKQISREVAKELLENILYDEMMMIES"
     gene            complement(3297..4268)
                     /locus_tag="KRO40_002377"
     CDS             complement(3297..4268)
                     /locus_tag="KRO40_002377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="HBH2093194.1"
                     /translation="MKKEESLLKVEGLKKYFEVKSGLFDKEIKCVKAVDGISFDLKKG
                     ETLAIVGESGCGKSTAGRTILRLIEKTEGKVEFNGVDIYKLEKEELRKLRPKMQMIFQ
                     DPYSSLNPRLNVEQIISEAVIEHNLVPKNEIKDNILNVVESCGLSKYHLNRKPGEFSG
                     GQRQRIGIARALALNPEFIVCDEPVSALDVSIQSQIINLLMDLQDKYKLSYLFISHDL
                     SVVNHIAHRVCVMYLGSIIEIATKGELYLHSQHPYTKALMSAVPIQDPTIKKNRIILK
                     GDIPSPTNPPSGCKFHTRCPYCKEICKKEIPVLKEISRNHFVACHLV"
     gene            complement(4269..5246)
                     /locus_tag="KRO40_002378"
     CDS             complement(4269..5246)
                     /locus_tag="KRO40_002378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093195.1"
                     /translation="MSKALIEVKDLKVYFHTDKGIVKSVNEVSFNINEGETIGIVGES
                     GCGKSVTAMSLMKLLPTSKIEGGEIIFRGKDILKMNEDELMGIRGNEISMIFQEPMTS
                     LNPAFTVGSQIIEGIMIHQDLSKEEAKKKVIDMIKLVEIPRAEEIYNSYPHELSGGMR
                     QRIMIAMALSCNPKLLIADEPTTALDVTIQAQILDIMKNIKEKLNTSIMMITHDLGVV
                     AEMCDKVLVMYAGKIIEVAEVVELFKNPKHPYTIGLLKSKPALGKNKDKRLYSIPGQV
                     PNPIGMPDSCYFSDRCEKVCDKCRTQIPPLIELNSGHSIACWLYKKEEI"
     gene            5465..7024
                     /locus_tag="KRO40_002379"
     CDS             5465..7024
                     /locus_tag="KRO40_002379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2093196.1"
                     /translation="MKFKKLASLILVSSLMLTFTACASNDKDKSSGSKSGGTVVIPMA
                     SDPDIINGAFANVKEDSLASNIVYAPLYTYEKGNLVNYLAEKVDFKDSKELTIKLKSN
                     LKWHDGKPITAEDVLFTFNTVLDEKQNSPSRQYLLVGEKPVKVEKIDDLTVKITLPTA
                     SESFLYGISKISPIPKHVFEGESNIAKSEKNNNPVGSGAFKFKEWKKGESIVFEKNAD
                     YFGGEPKADSIALKIIPNEASQEAALNNGEISLMKTSAEGYEKAKSNSNLQTYTYSEE
                     RLNYIVFNQNISNMANKEVRQALSYALNRNEMIESAYGKEGSVPAKSILVPEADFYTE
                     EGVEGYDQDTNKAKDLLDKSGVKIDKLKIGYNTGRFGHKNYALVAQQELKKIGIEAEI
                     VPYESKAFFNILFSNSTECDMYVNGYAWGLEPNPYRGMFETGQYCNQTKYSNAEIDAL
                     WEKGFTELNKEKREEIYKQIQQDISKDAPIYTIDYEQNLMAAQKNLKGIKDAKPSPAI
                     LFEDWSKLYVE"
     gene            7130..8089
                     /locus_tag="KRO40_002380"
     CDS             7130..8089
                     /locus_tag="KRO40_002380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093197.1"
                     /translation="MLKLILNRVKVLIPMLILISILSFGLLELAPGDPADAYINPLMS
                     SQDIENIRVNMGLDKPVYIRYLNWLKNTLSGNLGISYINHMPVTEQIMEKMGNTFILM
                     GTSLIFSILVAIPLGIFLAVNKNSITSKVSSVFNYIGVSIPSFWIGMILISIFSVKLN
                     IFPSGGMHTIGNDSIGDLVKHLVLPVITLGLYNTAIFTNYVEASVNEQLKKQYVITAR
                     AKGLSEKVILFKHVLKNSLTSLVTILGMSIQKLVTGAFVTEVVFSWPGMGRLMIDSIF
                     SRDYTVIMAITMLSALFLILGNLVADILYLLIDPKIKSSKGGF"
     gene            8092..8904
                     /locus_tag="KRO40_002381"
     CDS             8092..8904
                     /locus_tag="KRO40_002381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093198.1"
                     /translation="MFTSILKKLKKDKSFAFACITLSIIIILIITSFILNIDSNAIDT
                     TSKLQEPSLKHIFGTDELGRDYFSRALYGGRISLSVGILSMLISVVFGTAVGVISGYI
                     GGKLDQFLMRLVDMLMSIPSFLVLIVLNTYLTPKVSTIILIIGFLSWMEVSRIVRGET
                     LKIKENEYCLAAKATGIKTRNILLRHIVLNLKETIVVAGSLNIANAILTESALSFLGL
                     GIQLPLASWGNMLQDAQRHIFDKLYLAVFPGLLIFLTVMSLTIISKKFSSNT"
     gene            complement(9120..10022)
                     /locus_tag="KRO40_002382"
     CDS             complement(9120..10022)
                     /locus_tag="KRO40_002382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2093199.1"
                     /translation="MDIKQLKYFVEIVKSGFNLSIASKTLHISQPALSQIIKNFEESE
                     DVYLFERYKGRLNGLTPAGERFYVNAEHIINEYKNMMEDLREDSVQFKGKVRIGIPPL
                     ILGIAFSDVVAQLVANNPDIEFDIVEKGAYDLNRMLILQELDYAVLLHPHKIDKSVVT
                     EHVLQEDELTAFLNINHPLAKKDKIDWNDLNEQLLAIFNPTFMIHHKLMQKFTDENVK
                     LKRYIMSGSWDFLLLSTTNSDFITILPSPVHDFFENSKIIEKPFNHPITWKVILCRPK
                     KERYSHVDQHVFKFIIDFFSKKNS"
     gene            10377..11555
                     /locus_tag="KRO40_002383"
     CDS             10377..11555
                     /locus_tag="KRO40_002383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBH2093200.1"
                     /translation="MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVRLN
                     LSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSI
                     TSGENDVVIAGGTENMSQAPYIVPTARFGSKMGDITMVDSMLTDGLIDAFNQYHMGIT
                     AENIATKFEFTREMQDKLALESQNKAENAIKNNRFKEEIVPVDILIRRGKIETIDKDE
                     YPKLGMTFEGLAKLKPAFKKDGTVTAGNASGINDGAAMLILMSQQKADELGIRPLAKI
                     KSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAFAAQALAVKNELQID
                     SSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR
                     "
     gene            11564..12220
                     /locus_tag="KRO40_002384"
     CDS             11564..12220
                     /locus_tag="KRO40_002384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase subunit A"
                     /protein_id="HBH2093201.1"
                     /translation="MNKIVSIDEALSHVKDGDTIMVGGFMANGSPENLIDYLCSKNIK
                     DLTLICNDTGFIDKGVGKMVVNKQFKKIIASHVGLNKETGRQMNNNETDVELVPQGTL
                     AEQIRAAGYGLGGILTPTGIGTLVEEGKQKIVVDSKEYLLEKPIYADVALLFASKVDK
                     AGNLVYKGSMNNFNNLMASAAKITIVEADEIVEIGDIDPNEVNTPGIFVNYIVEGGNL
                     "
     gene            12220..12885
                     /locus_tag="KRO40_002385"
     CDS             12220..12885
                     /locus_tag="KRO40_002385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="HBH2093202.1"
                     /translation="MDKLEMQEYIANRVSKELKDGAVVNLGIGLPTKVANYIPDNVNV
                     ILQSENGFLGLGSAEDGNSSDETIVNAGGQPVTILPGGCFFDSATSFGIIRGGHVDIT
                     VLGALQVDKYGNIANYMIPGKMVPGMGGAMDLVTGAKKVIVAMEHTSKGSAKILNNCT
                     LPLTATNAVDLIVTEMGVMEVTSDGILLKKINPAFTLDDVISATEAPLILSDSLNGKI
                     SVV"
     gene            12990..13766
                     /locus_tag="KRO40_002386"
     CDS             12990..13766
                     /locus_tag="KRO40_002386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="HBH2093203.1"
                     /translation="MVKDKVVFVTGAASGIGKQIAESFLKNGAKVMFSDINQESLNNT
                     ITELQKKGYDCMSVKCDVTKEEEINHAIDKTVEKYGRLDILINNAGLQHVSMIEDFPT
                     DKFEFMIKIMLTAPFIATKKAFPIMKKQGFGRIINMASINGVIGFAGKAAYNSAKHGL
                     IGLTKVAALEAADSGITVNALCPGYVDTPLVRGQFNDLSKTRNIPLENVLEEVLYPLV
                     PQKRLLDVQEIADYAMFLASDNAKGITGQACLLDGGYTAQ"
     gene            13828..15162
                     /locus_tag="KRO40_002387"
     CDS             13828..15162
                     /locus_tag="KRO40_002387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBH2093204.1"
                     /translation="MSIIAPIGIIIGIIAIIYFSVKEIHITIAAPIATLIVVILNKMD
                     VVTSMLGADKNNYMGALGNYIMSYFAIFLLGSILAKFMEESGATVSIADFILNKFGSN
                     HPYRVLVAIFIVSFILTYGGISLFVVMFAVIPLARTLFKKLDISWNLIQIPLWLGIAT
                     ITMTIIPGTPAIQNVIPIQYLNTSLTAATIPSIVGSIGCATFGLVYMKYALNKSIRKG
                     ETYATYTSELEEESLDRELPGFFASIFPLLALVIIAITGSTFGSEFMKKNVIYIALIV
                     AILLSAFLFHKFLSSKIQTLSIGASGSIGPIFATSSAVAFGAVIMAAPGFDVFSKLIM
                     SIPGSPLISLTVLTSTMSAITGSSSGALGIVMPNFADYYLSTGLNPELIHRVATIASN
                     ILTIVPQSGVFLTFLSLSKLTHKTGFKETFIVVAVGSLIAEIIVITLGLLMY"
     gene            15659..16585
                     /locus_tag="KRO40_002388"
     CDS             15659..16585
                     /locus_tag="KRO40_002388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein"
                     /protein_id="HBH2093205.1"
                     /translation="MMRRNIPTKLKTILALGVLTLATASSAVTASASSLENNVNISNK
                     SLVYSNTKYKFSAKPNCSVKPELKPDKDNSCKDKNHNDKNCNNTNKPEDNNNSDSTNK
                     PDNNKPESNKPEDNNNSGSTNKPDNNKPESNKPEDNNNSGSTDKPDNNKPESNKPEDN
                     NNSDSTNKPDDNNNSGSTSESFSAYQKEVVDLVNIERAKAGLNPLTLDSSISNVATKK
                     SQDMIDNNYFSHNSPTYGSPFDMLKKFGISYKTAGENIAMGQKTPKEVVNAWMNSEGH
                     RKNIMNPNFSKIGVGVAQKSGGSIYWTQIFVG"
     gene            complement(16978..20517)
                     /gene="nifJ"
                     /locus_tag="KRO40_002389"
     CDS             complement(16978..20517)
                     /gene="nifJ"
                     /locus_tag="KRO40_002389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate:ferredoxin (flavodoxin) oxidoreductase"
                     /protein_id="HBH2093206.1"
                     /translation="MAKFMKTLDGNTAAAHVAYAFTDVAAIYPITPSSTMAEVVDEWA
                     SQGRKNIFGQTVNVVEMQSEAGASGTFHGSLQGGALTSTFTASQGLLLMIPNMYKVAG
                     ELLPGVFHVSARALASQALSIFGDHQDVMAARQTGCVLLASGSVQEVADIAPVAHLAA
                     IEGRLPFIHFFDGFRTSHEIQKVELLENEDYASLLNFEAVQAFRDNALSPNHPVARGT
                     AQNPDIYFQTREASNKYYQNIVGIVEKYMEKMSNLTGRKHSLFDYYGAEDAKYVLIAM
                     GSVTETIEETIDYLNAKGEKYGLVKVHLYRPFSMKHFLDAMPSTVERICVLDRTKEPG
                     STGEPLYLDVRDVFYGKENAPMIIGGRYGLGSKDTTPSDIKTVFDNLVSEQPKNGFTV
                     GIVDDVTNTSLTPSEPIKIASKGTIRCKFWGLGSDGTVGANKQAIKIIGDHTEKYAQA
                     YFDYDSKKSGGITMSHLRFGDTPIRATYLIDEADYIACHKQSYVYQYDLLKGLKKGGT
                     FVLNTIWDQAGLEEHLPAHMKQYIAKNDIKFYTVNAVKLGQEIGLGNRINMIMQSAFF
                     KLAEIIPEEDAVKYLKDSIVKAYGKKGEKIVNMNYAAVDAGINALVKVEVPASWENAV
                     DADKGEVKEPEFIKNILRPMTAQEGNNLPVSTFNGIEDGTFPCGTAAYEKRGIAVDVP
                     EWIIDNCIQCNQCSFICPHACIRPVLVTEEELANAPEGFEAKKALGKGLEGLKYRIQV
                     SPLDCTGCGNCADICPAKEKALVMKPIDTQLDTELDNWAFAVNPDEVAPKVDVMPANT
                     VKGSQFRQPLMEFSGACAGCGETAYIKVVTQLYGDRMMIANATGCSSIWGASAPSIPY
                     TCNHEGKGPSWANSLFEDNAEYGFGMYTAVKQIRNKIVDAMTELVSMDICEDAKAVFT
                     EWLDSRNDGEASKVASAKVVELLEKPACDCTDEKAKELVKAIKDRKDYLVKRSQWILG
                     GDGWAYDIGYGGLDHVLASGEDVNVLVFDTEVYSNTGGQASKATPAAAMAKFAASGKK
                     SRKKDLGMMAMTYGNVYVAQVAMGADKNQFIKAVLEAEKHDGPSLIIAYAPCINHGLK
                     EGMGRTVANEAQAVACGYWHLYRFNPEVKAEGKNPFTLDSKEPTASFKDFILAQVRYS
                     AIAKQFPEEADGLFAKAEADAKERYEGYKKLAE"
BASE COUNT         7217 a         3266 c         2919 g         7448 t
ORIGIN      
        1 tataaattca gtacagatat aactcttttg atatgtaatg ttaaataaag tagttcatct
       61 tgacttacat agtaatcata attcttttct acatgagttt ttattttata tgcacaatca
      121 taatcctttt catactttac tttaattata tctataattt cattatttgt atcattgatt
      181 ttttcttttt ttactaatcg ttttgcaaag aattttaaat gagtcagaag cctatcataa
      241 tttatatcat cttctttaaa ttcaactcta taataatatc ttataatatt tagtatgtct
      301 tttacaattt tagtaattaa tagtgattcc tttgaacttc ccttatagtt tgaatttact
      361 atatgcattg ctataaaacc agcttcatct actggaaatt tcacatcaaa ttctttattt
      421 atataatcta cagcccattt cccaatctca tattcttttt tatgtattct ttttatctca
      481 tgtagtaaat cattctttat agttatgttt tcatgatatc ttttaattgc aaatgcaata
      541 tggtcagtaa gtgctacata aatatattca taaagcttag tattcaaatt ctcctctgca
      601 taagcaatta tttcagtact aacctcaaaa aatttctcat caacctggct tgctagttta
      661 ctaattttat ctaaaaagct ttcatcttgt attacaaaag ttctttcaat tttactttta
      721 tctatttctt gacctttctt tttttgaaac ccaattccac atcctgttaa tattaattct
      781 ttttttatat tttcatctaa aactaataca acattattat tataaatttg ttgaataatc
      841 ataatcaata tctctcccaa aatacaattt cccttattca taaaaaaata cctaaattaa
      901 gatacaattc acctgtatac cttaacctag gtattgcctg cttaccagta acaatccagc
      961 ttgttaacgc ttatatattg tattcaattt atggttttat tctattataa ataaatatat
     1021 atgtcaagta aattattgaa aactatttcc tattttttag tattaatttt aacatcaaaa
     1081 atcaaatttt attccattat atttatgatt ctatcatcat catttcatca tagagaatat
     1141 tttccaataa ctctttagcc acttctcttg atatttgctt agtttcaact aattgttgaa
     1201 cactgtctct ttgactttgt atcgccatta ctctgtagta ttctactctt gcctcaaact
     1261 tatcatcatt ttgaatcttt ctagtaatcc aattcaaata acgattatag aatctgattg
     1321 ctattaaggc ctcatgtctg ttatcttcat cagtattttt atttataaat gatatagcag
     1381 ttttagtaga aagtgcatat gcatggtgaa actctttgat tatttcttta ttctcagata
     1441 ctatttttgt aattttttct tttacttctt tctttacttt tctatttata atccacatgc
     1501 ttatttttaa ttttacaatt ttaaatatag atttttgaac agattttctt gattttgtaa
     1561 tataaaatct atacaattta aaggctctat cagaaatttt accatcttct aatagtttca
     1621 aaacagctaa taatccctgt tggtctgctt ctgcaatcat catacttata agtttattat
     1681 ctggagtatt tagtattcct ttttctgagt ctaccaactg ttcatttaaa tcatgtataa
     1741 ctggttgtac ttcttgtgct ttttcattac taagttttaa aatggcttct ttcaaaatta
     1801 gtttatatgc ctctttatca gataataaag gttctgactc ttgtacgtta ttttttaata
     1861 atcttggcag taaaactgtt gccaatacta aacttataag aataacttct gatgatataa
     1921 ataaaacagt atctctcatt ggaaatacat ctttatcagc caaataaaaa ggtatagata
     1981 aggcagttgc tagtgtaaat gtaccatgaa caccacaagt agcaactatt agtgagtatt
     2041 tacatttaga aatactctct tttacaactt cttcatcctt aaaacctaaa aaacctacaa
     2101 aaaaattatt taaaggattc tttttaggtt ttataaaaga attatgccat aaatataccc
     2161 atataaatct tataacaaat aaaataagta caattaaagt agaaataaaa gtcaattcca
     2221 atgccatatt ttcattttta ctactaagtc ctgtatatat acttggtaac aaaaaaccaa
     2281 gcagtgtaaa gacaaatcca ttcaatacat actccaaaac ataccaagta ttgtctgata
     2341 ttatccttaa tttagtagtt gtattttgta aatgctcttt ttcaattcca tgagctatcc
     2401 ctgccattac aacagctagg attccagata ctcctatttc ttctgctaca aaatatacaa
     2461 aaagtggagt cattatttgt ataactatta ccattggaat ttcttccaaa ttccacttgt
     2521 gtaaactaag tcttattttt ataattatgt atcctaaaat acttcctact attattcctc
     2581 caaaagctgt aatcataaat tgaatccctg cctcttctat tgaaaaaact cctgtaactg
     2641 tggcaagtac tgcaacctta aatgctacta ctccagcagc atcatttaat aaagattcac
     2701 cttcaagtat actcatcata tttttaggaa aatttaatcc ttgtgtaatt gattttactg
     2761 ctactaaatc agttggagat attactgctg ccaaagcaaa tgaaacagat aatggcatcc
     2821 caggaataag aaaatgtata aagattccac ctgcaaacac ggttattaaa actaaaccaa
     2881 atgcaagaag caaaattggt tttctgagct ctaatagctc ttttctcgat acattttgtc
     2941 cttcactgaa tagtaatgga gctatgatac atattacaaa tatttctgga ttaaatgaaa
     3001 atgagaattt aaatggcaaa atagacaata taatccctag tacaatttga tatattgcaa
     3061 gaggaatatt actccacttt ttgctaaata cagttgaaat cgttgtacaa accaataatc
     3121 ccaacaatgt tactaaaatt gacataacta cctctctttt caataataat attatagatt
     3181 aaacttatat atcaactaac ttaatattaa cagcatgaaa tcccatctta atcaaaaaaa
     3241 ttttcagttt attctattat tcttattata tacatcaaat ttaatttttg aaatatctat
     3301 actagatgac atgcaacaaa atgatttctt gatatttctt ttaaaactgg aatctctttt
     3361 ttgcatattt ccttacaata agggcatctt gtatgaaact tacatccact tggtggattt
     3421 gttggagatg gtatgtctcc ttttaatata attctatttt tcttaattgt agggtcttgt
     3481 attggtactg cgctcataag cgcttttgta tatggatgtt gagaatgtaa gtaaagttct
     3541 cctttagttg caatttctat tatagaacct agatacataa cacaaactct atgtgcaata
     3601 tgatttacta cactcaaatc atgagatata aataaatatg aaagtttata tttatcctgt
     3661 aaatccataa gtaaatttat aatttgagat tgaatagaaa catctagtgc agaaacaggt
     3721 tcatcacaaa ctataaattc tggatttaat gctaatgctc ttgctatacc tattctctgt
     3781 ctttgacctc cagaaaactc acctggtttt ctatttaaat ggtacttaga aagaccacaa
     3841 ctttctacaa catttaatat attatctttt atttcattct ttggcactaa attatgttct
     3901 ataactgcct cggatattat ttgttccaca tttaatcttg gatttaatga actatatggg
     3961 tcttgaaata tcatttgcat tttgggtctt aactttctaa gttcttcctt ctctaactta
     4021 tatatatcta caccattaaa ttcaacttta ccttcagttt tttcaattaa tctaagaatg
     4081 gttcttcctg cagttgattt tccacatccc gattctccaa ctatagccaa agtttctcct
     4141 ttttttaaat caaaagaaat tccatctact gcctttacac atttaatttc cttatcaaat
     4201 aatccagatt taacttcaaa gtacttttta agaccttcta cttttaataa actctcttct
     4261 tttttcaatt atatctcctc ctttttatat aaccaacatg caatactatg accactattc
     4321 aattctatta aaggaggtat ctgagttcta catttatcac atactttttc acatctatca
     4381 ctaaaataac atgaatctgg catcccaatt ggatttggta cttgtcctgg aatcgaatac
     4441 aatcttttat ctttgttttt tccaagagca ggctttgatt ttagaagtcc aatagtataa
     4501 ggatgttttg gatttttaaa taattcaaca acctctgcca cttctataat tttaccagca
     4561 tacatcacta atactttgtc acacatttct gcaactactc ccaaatcatg tgtaatcatc
     4621 attatagatg tgtttaattt ttcttttata tttttcatta tatctaaaat ctgagcttga
     4681 atagtaacat ctaaagctgt tgttggttca tcagctataa gtaattttgg attacatgat
     4741 aaagccatag ctatcattat tcgttgtctc ataccacctg ataattcatg tggatatgaa
     4801 ttatatattt cttcagctct tggtatttct accagtttta tcatatcgat tacctttttc
     4861 ttagcttctt cctttgataa atcttgatgt atcataatac cttcaatgat ttgacttcca
     4921 acagtaaacg ctgggtttaa agatgtcatt ggttcttgaa aaatcattga tatctcattc
     4981 cctcttattc ccataagttc atcttcattc atctttaaaa tgtctttgcc tcgaaagatt
     5041 atttctccac cttctatttt tgatgttgga agtaacttca tcaaagacat ggctgttaca
     5101 gacttaccac atcctgattc tccaactatt ccaatagttt caccttcatt tatattaaaa
     5161 cttacttcat ttacactctt tacaatccct ttatctgtat gaaaataaac ttttaaatct
     5221 ttaacctcaa ttagtgcttt actcattatt ttctcctctc agcaaaatta cttaagataa
     5281 catacacctt ttgattgtat tttataaaaa tttaaattac aacattttct tacattttat
     5341 tatttttttc tattaattat aataatataa tagttaattt ctatatatat tgatttaata
     5401 atgattacta ttatacaata aaaaatatgt gttaaatatt attttatgga ggttttataa
     5461 gaatatgaaa tttaaaaaat tggcatcatt aatcttagtt tcatcattaa tgcttacatt
     5521 tacagcctgt gcttccaatg ataaagacaa gtctagtgga agcaaatctg gtggaactgt
     5581 tgtaatacct atggcaagtg acccagatat aatcaatgga gcttttgcaa acgttaaaga
     5641 agactctctt gcatcaaata tagtttatgc tcctctttat acttatgaaa aaggaaattt
     5701 agtaaattat ttagcagaaa aagtagattt taaagatagt aaggaattaa ctataaaatt
     5761 aaaatccaat ttaaaatggc atgatggaaa gccaataact gctgaagatg tcttatttac
     5821 atttaataca gttttagacg aaaaacaaaa ttcaccatca agacaatact tattggtggg
     5881 tgagaaacca gttaaagtag aaaaaattga tgatttaaca gttaagatta ctttaccaac
     5941 tgcaagtgaa tctttcttat atggtatatc taaaatttct ccaataccaa aacatgtgtt
     6001 tgaaggagaa tcaaatatag ctaagtcaga aaaaaataat aatccagttg gttctggtgc
     6061 attcaagttt aaggaatgga aaaaaggtga aagcatagta tttgaaaaga atgcagatta
     6121 ttttggtgga gaacctaagg cagattctat agcgctaaaa ataattccta atgaagcatc
     6181 tcaagaagca gctttaaata atggcgaaat ttcacttatg aagacatctg ctgaaggata
     6241 tgaaaaggca aaatcaaact caaacttaca aacttatact tatagtgaag aaagattaaa
     6301 ctacattgta tttaaccaaa atatatcaaa catggctaac aaagaagtaa gacaagcctt
     6361 atcatatgcc ttaaatagaa atgaaatgat agaatcagca tatggaaaag aaggttctgt
     6421 acctgctaaa tctatattag ttccagaagc agacttctat acagaagaag gtgttgaagg
     6481 atatgaccaa gatacaaata aggctaaaga tttattggat aaaagtggtg ttaaaattga
     6541 taaattaaaa ataggttata acacaggtag atttgggcat aaaaactatg ccttagtagc
     6601 tcaacaagag ttgaaaaaaa ttggtataga agctgaaata gttccttatg aaagtaaggc
     6661 attcttcaat atactattta gtaatagcac tgaatgtgat atgtatgtaa atggttatgc
     6721 ttggggatta gaaccaaacc catatagagg tatgtttgaa actggtcaat attgcaacca
     6781 aactaaatat tctaatgctg aaatagatgc tttatgggaa aaaggattta ctgagttaaa
     6841 caaggaaaaa cgtgaagaaa tatataagca aatacaacag gatatatcta aggatgcgcc
     6901 tatttacact atagattatg aacaaaattt aatggcagct caaaaaaatc taaaaggaat
     6961 aaaagatgct aaaccatctc ctgcaatatt atttgaagat tggtctaaac tgtatgtaga
     7021 ataattgatg taaaatttta tattattaat tagaaaagga gatgtctaaa aataatattg
     7081 ttttattatt ttaaaacgag acatctcttt taattaggag aatttactta tgttaaaatt
     7141 aatattgaat agagtaaaag ttttaatacc tatgttaatc ttaatatcta tattatcatt
     7201 tggactttta gaattagctc ctggtgaccc agcagatgca tatataaatc ctttaatgtc
     7261 ttcacaggat attgaaaata taagggttaa tatggggctt gataaaccag tatatataag
     7321 atatttaaac tggttgaaaa acactttaag tggaaactta ggtatttctt atataaacca
     7381 tatgcccgtt acagaacaaa ttatggaaaa aatgggaaat acatttattc ttatgggtac
     7441 ttctttgata ttttcaatat tggtagctat acctcttgga atatttttag ctgtaaataa
     7501 aaattcaata actagtaaag tatcatctgt ttttaattat ataggtgttt ctataccttc
     7561 tttttggata ggtatgatac tcatttcaat tttttcagtt aaacttaaca ttttcccatc
     7621 aggaggtatg catactattg gaaatgatag tattggagat ttagtaaaac atttagtttt
     7681 gcctgtaata actttaggtc tatataatac tgctattttt acaaattatg tagaagctag
     7741 tgtaaatgaa caattaaaaa aacaatatgt tattacagca agagcaaaag gattatcaga
     7801 aaaagtcata ctatttaaac atgtcttgaa aaattcactg acatcattgg ttacaatcct
     7861 aggcatgagt atacaaaaat tagtcactgg tgcatttgtt acagaagtag ttttctcttg
     7921 gccaggtatg ggaagattaa tgattgattc aattttttca agagattata ctgtaattat
     7981 ggcaataact atgttatcag cactattttt aattttaggt aatttagttg ctgatatact
     8041 atacttatta attgacccta aaataaaatc tagcaaagga ggattctagt tgtgtttaca
     8101 agtatcttaa aaaaattaaa aaaagataaa tcctttgctt ttgcatgtat tactcttagc
     8161 ataataatca tattaattat aacttctttt atattaaata tagactctaa tgcaattgat
     8221 actacttcta aacttcaaga acctagctta aagcatatct ttggtacaga cgaacttggt
     8281 agagattact tctctagagc tctttatggt ggaaggattt cacttagtgt tggtatttta
     8341 tcaatgctta tttctgtagt atttggtact gctgtaggtg ttattagtgg atatattgga
     8401 ggtaagctag accaattctt gatgagatta gtggatatgc ttatgagtat accaagtttc
     8461 ttagttttga ttgtattaaa tacttatcta acacctaaag tttccactat tatactaatt
     8521 attggattct taagttggat ggaagtttca agaattgtac gtggcgaaac attaaaaata
     8581 aaggaaaatg aatactgtct agctgctaaa gctactggta tcaaaactag aaatatacta
     8641 ttaagacata tagttttaaa cttaaaagag actattgtag ttgctggttc gttaaatatt
     8701 gctaatgcta tcttaactga atctgctctt agttttttag gtcttggaat ccaattgcct
     8761 cttgcatcat ggggtaatat gcttcaagat gctcaaagac atatttttga caagttatat
     8821 ttagctgtat ttccaggatt acttatattt ttaacagtca tgagtttgac tataataagc
     8881 aaaaaatttt ctagtaatac ttaacaaatt ttatatagaa aataaaaaca gtgattatct
     8941 aaagatatac actgttttta tttttcgttt aaaaaaatac atattttgta tattataact
     9001 ttaaatacta ctctaccatg ttatgtaaag cctattattg ctctcaaaca tatagatgaa
     9061 aaactaatag tttattataa taaaaattga tttatttatt tgttatttta ataacatttt
     9121 taagagttct ttttactaaa gaaatctata ataaatttaa atacatgttg gtctacatgg
     9181 ctataacgtt cttttttagg tctacatagt ataactttcc atgtaatagg atgattaaaa
     9241 ggcttttcta taattttgct attttcaaaa aaatcatgaa ctggtgatgg tagaattgtt
     9301 ataaaatcag aatttgtggt tgatagcaac aaaaaatccc atgaaccaga cattatatat
     9361 ctttttaact taacgttttc atcagtaaat ttttgcatta gcttatgatg tatcataaaa
     9421 gtaggattaa atattgcaag taactgctca ttcaaatcgt tccaatctat cttatccttc
     9481 ttagcaagtg gatgatttat atttaaaaat gctgtaagtt catcttcttg aagcacatgt
     9541 tcagttacta cacttttatc aattttatgt ggatgtaaca atactgcata atctaattcc
     9601 tgtaagataa gcattctatt taagtcatat gcacccttct ctactatatc aaattctata
     9661 tctggattat ttgcaactaa ctgtgcaact acatctgaaa atgctattcc aagtataagt
     9721 ggaggtattc ctattctaac ttttccttta aattgaactg aatcttctct taaatcttcc
     9781 atcatatttt tgtattcatt tatgatatgt tctgcattta cataaaatct ttctcctgct
     9841 ggtgttaacc catttaacct gcctttatac ctttcaaata aatatacatc ttcactttct
     9901 tcaaaatttt ttataatttg acttaatgct ggttgagata tgtgaagtgt cttagatgct
     9961 attgataaat taaaaccaga tttcactatt tcaacaaaat atttcaactg ttttatatcc
    10021 attttaaacc cccttcccca aaagtataat ttagattata ttttttcttc taatgatatt
    10081 ttataggaaa atcaacataa tttcattaat attttaacaa aatatttttc taaatctact
    10141 ataaattttt atcctataaa tttttcttat acactatata aaaaattaga cttagacaaa
    10201 acgctttttt cgccgtaatc tataattaga aacaggaaaa cctaaagcat taggaataaa
    10261 agtaattgaa atacttaaaa acaagcttgt attaaaaaag tactttatta tagtgttccc
    10321 taatttcttt attcagaaaa tttttaatta tcattcaaga aaggtaacta ttagatatga
    10381 aagatgtagt aatcgtatca gcagtcagaa cacctatagg aagttttgga ggtgtattta
    10441 aaaatacttc agctgttcaa cttggaacta tcgctgttaa agaagcgata tcacgtgtaa
    10501 gacttaattt atctgaaata gatgaagtaa taattggaaa tgttcttcaa acagggcttg
    10561 gacagaatgt tgctagacaa attgctataa atgcaggtat accaaattct gttccaagct
    10621 acacagtaaa taaattatgt ggttcagggc ttaaaagtgt ccagctagct gcccaatcaa
    10681 tcacatctgg tgaaaatgat gtggtaattg caggtggtac tgaaaatatg agccaagctc
    10741 cttatatcgt tccaactgct cgctttggta gtaaaatggg tgacataacc atggtagata
    10801 gtatgctaac agatggcctt attgatgctt tcaatcagta tcatatggga ataactgcag
    10861 aaaatattgc aactaaattt gaatttacta gagaaatgca agataaattg gcattagaaa
    10921 gtcaaaataa ggctgagaat gctataaaaa acaaccgctt taaagaagaa atcgttccag
    10981 tagatatttt aatacgtcga ggaaaaatag aaactattga taaagatgaa tatcctaaat
    11041 taggtatgac atttgaaggt ttagctaaac ttaaacctgc attcaaaaaa gatggtactg
    11101 taacagctgg aaatgcctca ggtattaatg atggtgcggc tatgttaata ctaatgagcc
    11161 aacaaaaagc agacgaacta ggtattagac cacttgctaa aataaaatcc tatgcttcag
    11221 ctggtgttga acctgaagtc atgggtactg gtccaatccc tgcaactaga aaagcactga
    11281 aaaaagctgg acttagcatc aatgatatag acttaataga agcaaacgaa gcgtttgctg
    11341 cccaagcatt agctgttaaa aatgaacttc aaatagattc atcaaagtta aatgttaatg
    11401 gtggtgcaat agcattagga catccaatag gagcaagtgg agctagaata cttgttacct
    11461 taatttatga aatgcaaaaa cgtaaagttg aaactggact tgcaacactt tgtattggtg
    11521 gtggtcaagg aatatcaatg gtggtttcac gataggagga aatatgaata aaatagttag
    11581 cattgatgaa gctctatctc atgtaaaaga tggagataca ataatggttg gtggattcat
    11641 ggccaatggt tcaccagaaa atttaattga ttatttatgt agtaaaaata taaaagattt
    11701 gacactaatt tgcaatgata ctggctttat tgacaaagga gttggcaaaa tggttgtaaa
    11761 taagcaattt aaaaagataa ttgcttctca tgtaggatta aataaagaaa ctggaagaca
    11821 aatgaacaac aatgaaacag atgttgagtt agttcctcag ggaactcttg ctgaacaaat
    11881 acgtgcagct ggttatggtc taggaggtat actcacaccg actggtattg gtactcttgt
    11941 tgaggaggga aagcaaaaaa ttgttgtcga tagcaaagaa taccttcttg aaaaaccaat
    12001 ttatgcagat gttgctcttc tatttgcatc aaaggtcgat aaagcaggta atctagttta
    12061 taaaggctct atgaacaatt ttaataattt aatggcatct gctgccaaaa ttacaatagt
    12121 tgaagcagat gaaatcgttg aaattggtga tattgaccca aatgaagtta atacaccagg
    12181 tatttttgtg aattacatcg ttgaaggagg taatttataa tggataaatt agaaatgcaa
    12241 gaatatattg caaatagagt atctaaagaa ttaaaagacg gagccgttgt aaaccttgga
    12301 ataggtctac caaccaaagt agcaaattat attccggata atgtaaacgt tatcttacaa
    12361 tctgaaaatg gatttttagg tttaggttca gccgaagatg gaaattcaag tgatgaaact
    12421 attgtaaatg caggtggtca accagttact atacttcctg gaggatgttt ctttgatagt
    12481 gctacttctt ttggaataat cagaggaggt catgttgata taactgttct tggcgcactt
    12541 caggttgaca aatatggcaa tatagcaaac tatatgattc caggtaagat ggttccaggt
    12601 atgggtggag ctatggacct agtaactgga gctaaaaaag ttattgtagc aatggaacat
    12661 acttcaaaag gttctgcaaa aatattaaat aattgtactc ttccacttac tgcaacaaat
    12721 gctgtagatt tgatagttac tgaaatggga gttatggaag taacatcaga tggaatttta
    12781 cttaaaaaaa taaatccagc tttcacatta gatgatgtta tttctgctac tgaagctcct
    12841 ttaatattgt cagattcatt aaatggaaaa atatctgttg tttaaaataa ttaaaactag
    12901 aaaataaaaa tctcttagac gtattacata taaatttgta ttgcttaaaa tattaatata
    12961 aaaataaaat aaaattggag gaaatgaaaa tggttaaaga taaagttgta ttcgtaacag
    13021 gagctgcaag tggaataggt aaacaaatag ctgaatcgtt cttaaaaaat ggtgctaaag
    13081 taatgttctc tgatataaat caagaatctt taaataatac cataacagag ttacaaaaaa
    13141 aaggttatga ttgcatgagt gtaaagtgtg atgtaactaa ggaagaagaa attaatcacg
    13201 ctatagacaa aactgttgaa aagtatggca gattagatat attaataaac aatgctggac
    13261 ttcaacatgt ttctatgata gaagatttcc caactgataa atttgaattt atgataaaaa
    13321 taatgctgac agcacctttt atagctacta aaaaagcatt tcctataatg aaaaaacaag
    13381 gctttggtcg tataataaat atggcctcaa tcaatggtgt aataggattt gctggaaagg
    13441 ctgcttataa ctcagcaaaa catggactta ttggactaac aaaagttgct gctcttgaag
    13501 ctgccgattc tggtataaca gttaatgctt tatgccctgg atatgtagat actccacttg
    13561 tcagaggtca gttcaatgac ctttcaaaaa ctcgtaatat accattggaa aatgtcttag
    13621 aggaagtttt atacccactt gtaccacaaa aacgcctatt agatgttcaa gaaattgccg
    13681 actatgctat gttcttagca agtgataatg ctaagggtat tacaggacaa gcttgcttac
    13741 tagatggagg atatactgca caatagttat tatatttagg gcttgaagaa agtattcttc
    13801 aggtccttct actaaggagg gatatttatg agtattatcg caccaattgg tataattatt
    13861 ggtatcatag ctattatata tttttcagtt aaagaaattc atataactat agctgctcca
    13921 atagcaactt taatagttgt tattttaaat aaaatggatg ttgtaacgtc aatgctaggt
    13981 gctgacaaaa acaattatat gggtgcactt ggaaactata taatgagtta ttttgcaata
    14041 ttcttattag gctcaatact tgctaaattt atggaagaaa gtggagctac tgtatcaata
    14101 gctgatttta ttttaaataa atttggctct aatcatcctt atagagtttt agttgctata
    14161 tttatagtaa gttttatatt aacgtatggt ggtataagcc tatttgtagt tatgtttgcg
    14221 gtcattccac ttgcaagaac tctatttaaa aaacttgata tttcttggaa ccttattcag
    14281 ataccacttt ggcttggtat tgcaacaatt actatgacta taattcctgg aacaccagcc
    14341 attcaaaatg ttatacctat tcaatatcta aatacgtctc ttactgcagc tactatacca
    14401 agtattgtag gtagtatagg ttgtgctaca tttggacttg tctatatgaa atatgctcta
    14461 aacaaaagta ttagaaaagg tgaaacttat gcaacttaca cttcagaatt agaagaagaa
    14521 tctttagata gagaattacc aggatttttt gcaagtattt ttcctctatt agcactcgta
    14581 attatagcta taactggaag tacttttggt tcagaattta tgaaaaaaaa tgtaatttac
    14641 atagctttaa tagttgcaat tcttttatct gcttttttat tccataaatt tctatcatct
    14701 aagatacaga cattgagcat aggtgctagt ggttctatag gtcctatatt tgctacatct
    14761 tctgcagttg catttggagc agtaataatg gctgcacctg gttttgatgt atttagcaaa
    14821 cttataatgt caataccagg tagtccactt ataagtctta ctgttttgac ttcaacaatg
    14881 tcagcaataa cagggtcctc ttctggtgca ttaggaatag taatgccaaa ctttgcagat
    14941 tattatttaa gtactggtct aaatccagaa ttaattcacc gtgttgctac aatagcctca
    15001 aatatactaa ctatagttcc acaaagtggt gtttttctta cattcttaag cttatctaag
    15061 ttaacacata aaactggatt taaagaaact ttcattgtag ttgcagttgg ttcactaata
    15121 gcagaaatta ttgtaattac attaggatta ctaatgtatt aatataaaac aaattaaaat
    15181 tcataatatg aaaggtggtg tctcaaagtg aactttttac ttaatgagac actcttttta
    15241 tatgaaataa cataagccta tcatttcaac aataaaaaag aaccttatct ctattttgag
    15301 acagaccctt tttatttctt aaagatttaa ataattataa tttgttgcta atacgaaagc
    15361 atctactgaa taaatttaac caaataaaaa aaaatttatc ataactataa atttacgtta
    15421 tggaattatt ataaaaatat tattttctct aactaagtaa ttccatacta tacaggcttt
    15481 taatacaaat tgtcaaacac actgaaatat acctatttat tccatatata tcttttttac
    15541 atatctttac agtaaaaaaa gtcttaatct tatgttagta tagattcacg ggtaaccccc
    15601 tacactaaag gttacaaatc agtaacattt ttagaatttt tagattaaga ggtgtttaat
    15661 gatgagaaga aatataccaa caaaattaaa aactatatta gctttaggag tgttaacttt
    15721 agcaacagct tcaagtgctg ttactgcaag tgcttcatca cttgaaaata atgtaaatat
    15781 aagtaacaaa agtttagtat atagtaatac taaatacaag ttttctgcaa aaccaaattg
    15841 ttctgtaaaa ccagaactta agcctgataa agataactct tgtaaggata agaatcataa
    15901 tgacaagaat tgcaacaaca ctaataaacc tgaggacaac aataattcag actctactaa
    15961 taagcctgat aacaataaac ctgagtctaa taaacctgaa gacaacaata attcaggctc
    16021 tactaataaa cctgataata ataaacctga gtctaataaa cctgaagaca acaataattc
    16081 aggctctact gataaacctg ataacaataa acctgagtct aataaacctg aagacaacaa
    16141 taattcagac tctactaaca aacctgatga taataacaac tcaggctcta caagtgaaag
    16201 tttttcagct taccaaaaag aagttgttga cttagtaaat atagaaagag ctaaagctgg
    16261 attaaatcct cttactcttg attcttctat atcaaatgtt gctacaaaaa aatctcaaga
    16321 tatgattgat aacaactatt tttcacacaa ttctccaact tatggttctc catttgacat
    16381 gttgaaaaaa tttggaataa gctataagac agcaggtgaa aatatagcta tgggtcaaaa
    16441 aactcctaaa gaagttgtaa acgcatggat gaattctgaa ggtcacagaa aaaatataat
    16501 gaatccaaat ttcagtaaaa taggtgttgg agtagcacaa aaaagtggtg gttcaattta
    16561 ttggacacaa atctttgtag gataaaatac tctttttcca tacatatcaa aagagtatct
    16621 ctaagtgata aaaaacacaa atgagatact cttttgtatc tattttaaaa ttatcaaatc
    16681 caaatataca tactataaat attatttgtt ctcttaattt tagtgtgtag agcaatatat
    16741 aaaaagtatt ggcaagatga aaatggaaaa cttaaaaaag atatttaata ggtaaaaaca
    16801 aaatcttaat atcttcataa aaaaaggctg tctcaaaata gagataaggc ctttttcatt
    16861 gttgaaatga ttaaaatata tttgatttca tacaaaaaga gtgcctcatg aactaaaaag
    16921 ctcactttga gacactctct tttatcaatt ctatataagc attataatac tttaatatta
    16981 ttcagctaat tttttgtatc cttcatatct ttctttagca tcagcttcag ctttagcaaa
    17041 taatccatca gcttcctctg ggaattgttt agctatagca gaatatctta cttgtgcaag
    17101 tatgaaatct ttgaagcttg cagttggttc ttttgaatct aaagtgaatg ggtttttacc
    17161 ttcagctttt acttctggat tgaatctgta taaatgccag tatccgcaag caacagcttg
    17221 tgcttcatta gctacagttc ttcccatacc ttcttttaat ccatggttta tacatggagc
    17281 ataagctatt attagagatg gcccatcatg tttttcagct tctaaaacgg ctttgataaa
    17341 ttgattttta tcagcaccca tagcaacttg agctacatat acgtttccat atgtcatagc
    17401 catcattcct aaatctttct ttctagattt tttacctgaa gcagcaaact tagccatagc
    17461 agcagctgga gtagctttag aagcttgacc tcctgtattt gaatatactt ctgtatcaaa
    17521 tacaagtacg tttacatctt caccagatgc aagaacatgg tctaatccac cataaccgat
    17581 atcatatgcc caaccgtctc cacctagtat ccattgagat ctcttaacta gataatcttt
    17641 tctatctttt atagctttta ctaattcttt agctttttca tctgtacaat cacaagctgg
    17701 tttttctaat aattcaacaa ccttagcact tgctacttta gaagcttctc catcatttct
    17761 agaatctaac cactctgtaa atactgcttt agcatcttca cagatatcca tagaaactaa
    17821 ctctgtcata gcatctacta ttttatttct tatttgctta acagctgtgt acataccaaa
    17881 tccatattca gcattatcct cgaataaaga atttgcccaa gatggacctt taccttcatg
    17941 gttacaagta taaggaattg atggtgcaga agctccccat atagaagaac atccagtagc
    18001 attagctatc atcattctat ctccatataa ttgtgtaact actttaatgt acgcagtttc
    18061 tccacatcca gcacatgctc ctgaaaactc cattaatggt tgtctaaatt gacttccttt
    18121 aacagtattt gcaggcataa catcaacttt tggagctact tcatcaggat ttactgcaaa
    18181 tgcccaatta tctaactctg tatcaagttg agtatctatt ggcttcataa ctaaagcttt
    18241 ttctttagct ggacatatgt cagcacagtt tccacatcct gtacagtcaa gtggactaac
    18301 ttgaattcta tattttaatc cttctaatcc tttacctaat gcttttttag cttcaaatcc
    18361 ttctggagca ttagctaatt cttcttcagt aactaatact ggtcttatac atgcatgagg
    18421 acatataaaa gaacattggt tacattgaat acagttatct attatccatt caggaacatc
    18481 aacagctata ccacgttttt cataagctgc agtaccacaa gggaatgttc catcttctat
    18541 accattgaat gtacttactg gtaagttgtt tccttcttgt gcagtcattg gtcttagtat
    18601 attttttata aattctggtt ctttaacttc tcctttatct gcatcaacag cattttccca
    18661 agaagctgga acttcaactt taactaaagc atttattcct gcatcaacag cagcatagtt
    18721 catattaact attttttcac cttttttacc ataagcttta actatagaat cttttaagta
    18781 tttaacagca tcttcttctg gtattatttc agctaattta aagaatgcag attgcattat
    18841 catgtttatt ctgtttccaa gacctatttc ttgtcctagt ttaacagcgt taactgtata
    18901 gaattttata tcatttttag ctatatattg tttcatatga gctggtaaat gttcttcaag
    18961 tcctgcttgg tcccatatag tgttaagtac aaatgtacca ccttttttaa gaccttttaa
    19021 taaatcatat tgataaacat atgattgttt atgacaggca atataatcag cttcatctat
    19081 taaataagta gctcttattg gagtatcacc aaatcttaag tgagacatag ttataccacc
    19141 agatttttta gagtcataat caaagtaagc ttgagcatat ttttcagtat ggtcaccgat
    19201 tattttgata gcttgtttat tagctccaac agtaccgtca gaacctaatc cccagaactt
    19261 acatcttata gttcctttag aagctatttt tattggctca gatggagtta aagaagtatt
    19321 agttacatca tcaactatac ctactgtaaa tccattttta ggttgttctg aaactaagtt
    19381 atcaaaaaca gtttttatat ctgaaggagt agtatctttt gaacctaatc cgtatcttcc
    19441 acctattatc ataggagcat tttcttttcc atagaataca tcacgtacat ctaagtataa
    19501 tggttcacca gttgaacctg gctctttagt tctatcaagt acacatattc tttcaacagt
    19561 agatggcata gcatctaaga aatgtttcat tgagaatggt ctatataaat gaactttaac
    19621 taaaccatat ttttctccct tagcatttaa gtaatctata gtttcttcta ttgtttctgt
    19681 tactgaaccc atagctatta atacgtattt agcatcttct gctccatagt aatcaaataa
    19741 actatgtttt ctacctgtta aattactcat tttttccatg tatttttcaa ctatacctac
    19801 tatattttga tagtatttat tagaagcttc tctagtttgg aaatatatat ctgggttttg
    19861 agcagtacca cgagcaactg gatgatttgg agataaagca ttatctctaa atgcttgaac
    19921 tgcttcaaag tttaataaac ttgcataatc ttcattttct agtaattcaa ctttttggat
    19981 ttcatgtgaa gttctgaatc catcaaagaa atgtataaat ggtaatctac cttctattgc
    20041 agctaaatgt gcaacaggtg ctatatcagc tacttcttga actgaaccag aagctaataa
    20101 tacacatcca gtttgtctag cagccataac gtcttggtga tccccaaata ttgataacgc
    20161 ttgagatgct aaagcacgag cacttacatg gaatactcct ggtaataact ctcctgcaac
    20221 tttatacatg ttaggtatca ttaataataa accttgagat gctgtaaaag tagaagttaa
    20281 agctcctcct tgtaaagaac cgtggaatgt tcctgatgca cctgcttctg actgcatttc
    20341 aacaacatta actgtttgtc caaatatatt ttttcttcct tgtgatgccc actcatcaac
    20401 tacttcagcc atagttgaag atggtgtgat tggatatata gctgctacat ctgtaaacgc
    20461 ataggcaaca tgagctgcag ctgtatttcc atcaagtgtt ttcataaact tagccataat
    20521 atgtatcctc cttgatagct acaattgtac ttgtttataa caagtctatt tttttatatt
    20581 tacatataat ttacacaaca aaaatataaa cacacatata gtcgcgcaaa tactctatct
    20641 tctaatataa tactacagat tagataaaat tcctttgaaa attgtaaatt aattacatat
    20701 ttaagtagat tttttttaaa attaaatatg ttaagttttt ttcataattt tgtatacaat
    20761 atataataaa ttaagttaga cttttcaaac ttttttatct atttgtttat attagtacaa
    20821 aaagtaaaat aattatcttt attatatgta
//
LOCUS       DAEQCW010000067        20772 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.067, whole genome shotgun sequence.
ACCESSION   DAEQCW010000067 DAEQCW010000000
VERSION     DAEQCW010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20772)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20772)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20772
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.067"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            525..1781
                     /locus_tag="KRO40_002390"
     CDS             525..1781
                     /locus_tag="KRO40_002390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBH2093207.1"
                     /translation="MIEKFKTLIWIKMIIKIKSVYKTYGGLFLLGLIGIPIGAIIGLI
                     DTIFGTVLLKVTDIRETYPMYLIPFLAVVGVVIAYCYFKFGGKSSKGMNLIFEVGHGE
                     EEIIPLRLVPFIILGTWLTHLFGGSAGREGVAVQIGATFSHWVGKRLPIKNASSIFLV
                     TGMAAGFAGLFETPIAAILFAMEVLVAGSLEYQSLFPAFTASFTASAVSKALGLEKFS
                     FALSSKVVFDLSIFWKLIVLGIIFGMVGGAFAWCLKLSKRKIGNRLKNPMIRIAIIGV
                     CLSVLFLLFYKGRYSGLGTNLIQNSFYGGEIYSFDWLLKFILTILTLSAGFQGGEVTP
                     LFSIGASLGVLLAGFFNLPIELVAALGYASVFGSATNTFFAPVFIGAEVFGYSYLPYF
                     FVVCAISYIFNMDKSIYSLQKISTKQ"
     gene            1844..3037
                     /locus_tag="KRO40_002391"
     CDS             1844..3037
                     /locus_tag="KRO40_002391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBH2093208.1"
                     /translation="MLTSLALIFLLGMASGGIFKRIKLPNLLGMLLTGIILGPYVLNL
                     IDNSILDISSDLRKIALIIILTRAGLSLDINDLKKVGRPAVLMCFIPATFEIVGMIVL
                     APKLLGVSILEAAVMGAVVGAVSPAIIVPKMLKLMEEGYGTEKSIPQMLLAGTSIDDI
                     FVIVMFTVFTGLAQGNSISAISFLQIPVSIILGVIVGAVIGICLAVFFKKIHMRDSAK
                     GVLLLSISFLMISLETALEGIVPFSGLLAVMSIGIFLQIKYRVVARRLSIKYSKLWVG
                     AEILLFVLVGATVDISYAFKAGIGAVILIFGVLLFRMVGVFFCLIKTNLTIKERLFCM
                     IGYIPKATVQAAIGGVPLAMGMASGQLILTLAVLAILITAPLGAFGIDVTYKKLLTSV
                     KGENK"
     gene            3238..3618
                     /locus_tag="KRO40_002392"
     CDS             3238..3618
                     /locus_tag="KRO40_002392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093209.1"
                     /translation="MCLKKLSKLELVIMKFIWNLDIKTNSYEIIDYMKEEHNLPEKVA
                     LKTLSKLSKKRFLYVQETGKCMYYTVAIKEKAYLEFISRNVQNLLKNNFIRNLLVSFH
                     EEELTEEKIKSLENWVVNWEEAYV"
     gene            4525..5079
                     /gene="tcdR"
                     /locus_tag="KRO40_002393"
     CDS             4525..5079
                     /gene="tcdR"
                     /locus_tag="KRO40_002393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin sigma factor TcdR"
                     /protein_id="HBH2093210.1"
                     /translation="MQKSFYELIVLARNNSVDDLQEILFMFKPLVKKLSRVLHYEEGE
                     TDLIIFFIELIKNIKLSSFSEKSDAIIVKYIHKSLLNKTFELSRRYSKMKFNFVEFDE
                     NILNMKNNYQSKSVFEEDICFFEYILKELSGIQRKVIFYKYLKGYSDREISVKLKISR
                     QAVNKAKNRAFKKIKKDYENYFNL"
     gene            5397..12497
                     /gene="tcdB"
                     /locus_tag="KRO40_002394"
                     /gene_synonym="toxB"
     CDS             5397..12497
                     /gene="tcdB"
                     /locus_tag="KRO40_002394"
                     /gene_synonym="toxB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_074049122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdB"
                     /protein_id="HBH2093211.1"
                     /translation="MSLVNRKQLEKMANVRFRTQEDEYVAILDALEEYHNMSENTVVE
                     KYLKLKDINSLTDIYIDTYKKSGRNKALKKFKEYLVTEVLELKNNNLTPVEKNLHFVW
                     IGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTVVESAINDTLESFREN
                     LNDPRFDYNKFFRKRMEIIYDKQKNFINYYKAQREENPELIIDDIVKTYLSNEYSKEI
                     DELNTYIEESLNKITQNSGNDVRNFEEFKNGESFNLYEQELVERWNLAAASDILRISA
                     LKEIGGMYLDVDMLPGIQPDLFESIEKPSSVTVDFWEMTKLEAIMKYKEYIPEYTSEH
                     FDMLDEEVQSSFESVLASKSDKSEIFSSLGDMEASPLEVKIAFNSKGIINQGLISVKD
                     SYCSNLIVKQIENRYKILNNSLNPAISEDNDFNTTTNTFIDSIMAEANADNGRFMMEL
                     GKYLRVGFFPDVKTTINLSGPEAYAAAYQDLLMFKEGSMNIHLIEADLRNFEISKTNI
                     SQSTEQEMASLWSFDDARAKAQFEEYKRNYFEGSLGEDDNLDFSQNIVVDKEYLLEKI
                     SSLARSSERGYIHYIVQLQGDKISYEAACNLFAKTPYDSVLFQKNIEDSEIAYYYNPG
                     DGEIQEIDKYKIPSIISDRPKIKLTFIGHGKDEFNTDIFAGFDVDSLSTEIEAAIDLA
                     KEDISPKSIEINLLGCNMFSYSINVEETYPGKLLLKVKDKISELMPSISQDSIIVSAN
                     QYEVRINSEGRRELLDHSGEWINKEESIIKDISSKEYISFNPKENKITVKSKNLPELS
                     TLLQEIRNNSNSSDIELEEKVMLTECEINVISNIDTQIVEERIEEAKNLTSDSINYIK
                     DEFKLIESISDALCDLKQQNELEDSHFISFEDISETDEGFSIRFINKETGESIFVETE
                     KTIFSEYANHITEEISKIKGTIFDTVNGKLVKKVNLDTTHEVNTLNAAFFIQSLIEYN
                     SSKESLSNLSVAMKVQVYAQLFSTGLNTITDAAKVVELVSTALDETIDLLPTLSEGLP
                     IIATIIDGVSLGAAIKELSETSDPLLRQEIEAKIGIMAVNLTTATTAIITSSLGIASG
                     FSILLVPLAGISAGIPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDKIMMP
                     QDDLVISEIDFNNNSIVLGKCEIWRMEGGSGHTVTDDIDHFFSAPSITYREPHLSIYD
                     VLEVQKEELDLSKDLMVLPNAPNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEF
                     YWRYFAFIADALITTLKPRYEDTNIRINLDSNTRSFIVPIITTEYIREKLSYSFYGSG
                     GTYALSLSQYNMGINIELSESDVWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIE
                     ENKIILNSHEINFSGEVNGSNGFVSLTFSILEGINAIIEVDLLSKSYKLLISGELKIL
                     MLNSNHIQQKIDYIGFNSELQKNIPYSFVDSEGKENGFINGSTKEGLFVSELPDVVLI
                     SKVYMDDSKPSFGYYSNNLKDVKVITKDNVNILTGYYLKDDIKISLSLTLQDEKTIKL
                     NSVHLDESGVAEILKFMNRKGNTNTSDSLMSFLESMNIKSIFVNFLQSNIKFILDANF
                     IISGTTSIGQFEFICDENDNIQPYFIKFNTLETNYTLYVGNRQNMIVEPNYDLDDSGD
                     ISSTVINFSQKYLYGIDSCVNKVVISPNIYTDEINITPVYETNNTYPEVIVLDANYIN
                     EKINVNINDLSIRYVWSNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKLSFNF
                     SDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEKFYINNFGMMLSGLIYINDSL
                     YYFKPPVNNLITGFVTVGDDKYYFNPINGGAASIGETIIDDKNYYFNQSGVLQTGVFS
                     TEDGFKYFAPANTLDENLEGEAIDFTGKLIIDENIYYFDDNYRGAVEWKELDGEMHYF
                     SPETGKAFKGLNQIGDDKYYFNSDGVMQKGFVSINDNKHYFDDSGVMKVGYTEIDGKH
                     FYFAENGEMQIGVFNTEDGFKYFAHHNEDLGNEEGEEISYSGILNFNNKIYYFDDSFT
                     AVVGWKDLEDGSKYYFDEDTAEAYIGLSLINDGQYYFNDDGIMQVGFVTINDKVFYFS
                     DSGIIESGVQNIDDNYFYIDDNGIVQIGVFDTSDGYKYFAPANTVNDNIYGQAVEYSG
                     LVRVGEDVYYFGETYTIETGWIYDMENESDKYYFNPETKKACKGINLIDDIKYYFDEK
                     GIMRTGLISFENNNYYFNENGEMQFGYINIEDKMFYFGEDGVMQIGVFNTPDGFKYFA
                     HQNTLDENFEGESINYTGWLDLDEKRYYFTDEYIAATGSVIIDGEEYYFDPDTAQLVI
                     SE"
     gene            12619..13119
                     /gene="tcdE"
                     /locus_tag="KRO40_002395"
     CDS             12619..13119
                     /gene="tcdE"
                     /locus_tag="KRO40_002395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holin-like glycosylating toxin export protein
                     TcdE"
                     /protein_id="HBH2093212.1"
                     /translation="MHSSSPFYISNGNKIFFYINLGGVMNMTISFLSEHIFIKLVILT
                     ISFDTLLGCLSAIKSRKFNSSFGIDGGIRKVAMIACIFFLSVVDILTKFNFLFMLPQD
                     CINFLRLKHLGISEFFSILFILYESVSILKNMCLCGLPVPKRLKEKIAILLDAMTDEM
                     NAKDEK"
     gene            13448..13630
                     /locus_tag="KRO40_002396"
     CDS             13448..13630
                     /locus_tag="KRO40_002396"
                     /inference="COORDINATES: protein motif:HMM:NF022413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093213.1"
                     /translation="MRDEGQNDIENKYQTLINDLIDSLKVIGKIYKEIKTLKKYKICL
                     QITIRQSPYLIEESIN"
     gene            13847..>20772
                     /gene="tcdA"
                     /locus_tag="KRO40_002397"
                     /gene_synonym="toxA"
     CDS             13847..>20772
                     /gene="tcdA"
                     /locus_tag="KRO40_002397"
                     /gene_synonym="toxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_105161403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdA"
                     /protein_id="HBH2093214.1"
                     /translation="MSLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENK
                     YLQLKKLNESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFVWI
                     GGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTTEALQLLEEEI
                     QNPQFDNMKFYKKRMEFIYDRQKRFINYYKSQINKPTVPTIDDIIKSHLVSEYNRDET
                     VLESYRTNSLRKINSNHGIDIRANSLFTEQELLNIYSQELLNRGNLAAASDIVRLLAL
                     KNFGGVYLDVDMLPGIHSDLFKTISRPSSIGLDRWEMIKLEAIMKYKKYINNYTSENF
                     DKLDQQLKDNFKLIIESKSEKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGS
                     YLTNLVIEQVKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIA
                     PYLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEFKFPENNLS
                     QLTEQEINSLWSFDQASAKYQFEKYVRDYTGGSLSEDNGVDFNKNTALDKNYLLNNKI
                     PSNNVEEAGSKNYVHYIIQLQGDDISYEATCNLFSKNPKNSIIIQRNMNESAKSYFLS
                     DDGESILELNKYRIPERLKNKEKVKVTFIGHGKDEFNTSEFARLSVDSLSNEISSFLD
                     TIKLDISPKNVEVNLLGCNMFSYDFNVEETYPGKLLLSIMDKITSTLPDVNKNSITIG
                     ANQYEVRINSEGRKELLAHSGKWINKEEAIMSDLSSKEYIFFDSIDNKLKAKSKNIPG
                     LASISEDIKTLLLDASVSPDTKFILNNLKLNIESSIGDYIYYEKLEPVKNIIHNSIDD
                     LIDEFNLLENVSDELYELKKLNNLDEKYLISFEDISKNNSTYSVRFINKSNGESVYVE
                     TEKEIFSKYSEHITKEISTIKNSIITDVNGNLLDNIQLDHTSQVNTLNAAFFIQSLID
                     YSSNKDVLNDLSTSVKVQLYAQLFSTGLNTIYDSIQLVNLISNAVNDTINVLPTITEG
                     IPIVSTILDGINLGAAIKELLDEHDPLLKKELEAKVGVLAINMSLSIAATVASIVGIG
                     AEVTIFLLPIAGISAGIPSLVNNELILHDKATSVVNYFNHLSESKKYGPLKTEDDKIL
                     VPIDDLVISEIDFNNNSIKLGTCNILAMEGGSGHTVTGNIDHFFSSPSISSHIPSLSI
                     YSAIGIETENLDFSKKIMMLPNAPSRVFWWETGAVPGLRSLENDGTRLLDSIRDLYPG
                     KFYWRFYAFFDYAITTLKPVYEDTNIKIKLDKDTRNFIMPTITTNEIRNKLSYSFDGA
                     GGTYSLLLSSYPISTNINLSKDDLWIFNIDNEVREISIENGTIKKGKLIKDVLSKIDI
                     NKNKLIIGNQTIDFSGDIDNKDRYIFLTCELDDKISLIIEINLVAKSYSLLLSGDKNY
                     LISNLSNTIEKINTLGLDSKNIAYNYTDESNNKYFGAISKTSQKSIIHYKKDSKNILE
                     FYNDSTLEFNSKDFIAEDINVFMKDDINTITGKYYVDNNTDKSIDFSISLVSKNQVKV
                     NGLYLNESVYSSYLDFVKNSDGHHNTSNFMNLFLDNISFWKLFGFENINFVIDKYFTL
                     VGKTNLGYVEFICDNNKNIDIYFGEWKTSSSKSTIFSGNGRNVVVEPIYNPDTGEDIS
                     TSLDFSYEPLYGIDRYINKVLIAPDLYTSLININTNYYSNEYYPEIIVLNPNTFHKKV
                     NINLDSSSFEYKWSTEGSDFILVRYLEESNKKILQKIRIKGILSNTQSFNKMSIDFKD
                     IKKLSLGYIMSNFKSFNSENELDRDHLGFKIIDNKTYYYDEDSKLVKGLININNSLFY
                     FDPIEFNLVTGWQTINGKKYYFDINTGAALTSYKIINGKHFYFNNDGVMQLGVFKGPD
                     GFEYFAPANTQNNNIEGQAIVYQSKFLTLNGKKYYFDNDSKAVTGWRIINNEKYYFNP
                     NNAIAAVGLQVIDNNKYYFNPDTAIISKGWQTVNGSRYYFDTDTAIAFNGYKTIDGKH
                     FYFDSDCVVKIGVFSTSNGFEYFAPANTYNNNIEGQAIVYQSKFLTLNGKKYYFDNNS
                     KAVTGWQTIDSKKYYFNTNTAEAATGWQTIDGKKYYFNTNTAIASTGYTIINGKHFYF
                     NTDGIMQIGVFKGPNGFEYFAPANTDANNIEGQAILYQNEFLTLNGKKYYFGSDSKAV
                     TGWRIINNKKYYFNPNNAIAAIHLCTINNDKYYFSYDGILQNGYITIERNNFYFDANN
                     ESKMVTGVFKGPNGFEYFAPANTHNNNIEGQAIVYQNKFLTLNGKKYYFDNDSKAVTG
                     WQT"
BASE COUNT         8177 a         2161 c         3328 g         7106 t
ORIGIN      
        1 taaatcatgt atcataatga aaagtaaaga aaatcattta aattatatat cataaaaata
       61 atatgaaata ttgaacactc ataatattag agactttaat attttaattg ataggttata
      121 ttatttataa cattaaaaat acaatttaca taaaatagac atatgaaaaa taaaaaatta
      181 tataataatt atgggaatga ggttctccct tggatgataa tatcctaaac tgccaatgag
      241 ctgatgactt ctatgatatc atagatgcca ccagcttttt ttgttgttta aatcgataaa
      301 atggaggtga attacttact aaatttttat tttttaaatt tgaagaaata tttaatcaat
      361 aaaaaaaata gtagattata tgttaattat tttattaaga atgggttaag agtgtaccta
      421 tatcctatca attaaaaaaa caattacgat agtcattaca ttgactacag ttgatgcaat
      481 aaaactttca aaaaatctta tgatgcaaat agaaaggaat taaaatgata gaaaaattta
      541 aaactttaat atggattaaa atgataataa aaattaaaag cgtttataaa acatatggtg
      601 gactattttt gttaggactc ataggtatac caattggtgc aattataggt cttatagaca
      661 ccatatttgg aacggttctt ctaaaagtta cagatattcg agaaacatat ccaatgtatc
      721 tgataccatt tttagcagta gtaggagttg ttattgctta ttgctatttt aaatttggag
      781 gaaaaagtag taaaggaatg aatctaatat ttgaggtagg gcatggagaa gaagaaatta
      841 ttcctttaag attggttcca tttataatat taggtacatg gttaacccat ttatttggtg
      901 gtagtgcagg acgagaagga gttgctgttc agattggtgc aactttttca cattgggtag
      961 gtaaaaggtt gcctataaaa aatgcttcta gtatttttct agtaactggt atggcagctg
     1021 gttttgcagg attatttgag acaccaatag cagcaatact atttgctatg gaggttttgg
     1081 tagctggttc actggagtat caatcgcttt ttcctgcgtt tactgcttct tttacagcaa
     1141 gtgcagtatc aaaagcttta gggttagaga aattttcttt tgcactttct tctaaagttg
     1201 tatttgactt gtcaatattt tggaagctta ttgttttagg aattattttt ggaatggttg
     1261 gtggagcatt tgcatggtgt ctgaaattgt caaaaagaaa aatagggaat agattaaaaa
     1321 atcctatgat aagaattgct attattggag tatgtcttag tgtattattc cttttatttt
     1381 ataaaggaag atattcaggt ttagggacaa atttaattca aaatagtttc tatggtggag
     1441 aaatttattc atttgactgg ctgttaaagt ttatacttac aatactgact ttgtcagcag
     1501 gttttcaagg aggagaggtt acacctttgt tttccattgg agctagtctt ggtgtattgt
     1561 tagcaggatt ttttaatttg ccaattgaat tagttgcagc gcttggctat gctagtgtct
     1621 ttggtagtgc tacaaatact ttttttgcac ctgtatttat aggggcagaa gtttttggat
     1681 acagctattt accttatttc tttgtagtat gcgctatttc atatatattt aatatggata
     1741 aatctattta ttcactacaa aaaatttcaa caaaacaata aataaaacaa cataatgtat
     1801 gattagaaga gaaagaatat tagagaaagg atagggtagg aatatgttga caagtttagc
     1861 tttgattttt ttattaggaa tggcctcggg aggtattttt aagaggataa agttacctaa
     1921 cttattggga atgttactta caggaattat attaggtcca tatgttttaa atttgattga
     1981 taattcaata ctagatattt cttctgacct tagaaagatt gcattgatta ttatattaac
     2041 aagggctgga ttatctttag atataaacga tttgaagaaa gtgggaagac ctgctgtact
     2101 tatgtgcttt attccagcta cttttgaaat tgtcggaatg atagttttag caccaaagtt
     2161 actaggcgtt tctatattgg aagcagcagt catgggtgca gtagtaggag cagtttctcc
     2221 cgcaattatt gtacctaaaa tgcttaaatt aatggaagaa ggttatggta cagaaaaaag
     2281 tattccacag atgcttttag caggaacttc tatagacgat attttcgtaa ttgtgatgtt
     2341 tacagtattc acaggattgg cacaaggaaa tagtatatca gctattagtt ttttacaaat
     2401 tccagtatca attatattag gtgtaatagt tggagcagtg attggaatct gtttagcagt
     2461 attttttaag aagattcata tgagagattc tgctaaagga gtgttgcttt taagtatctc
     2521 atttttaatg ataagtttag agactgcttt agagggtatt gtgccatttt ctggattatt
     2581 agcagttatg agtattggga ttttccttca gataaaatat cgtgtagttg caagaagatt
     2641 gtctataaag tattcgaaac tatgggttgg tgctgaaatt ctcttgtttg ttttggtagg
     2701 ggcaacagta gatataagtt atgcatttaa agcaggaatt ggagctgtaa ttttaatatt
     2761 tggagttctt ttattccgta tggtaggagt attcttctgc cttattaaga caaatttgac
     2821 aataaaggaa agattgttct gtatgattgg ctatattcca aaggctacag tacaggcagc
     2881 aataggaggt gtaccacttg caatggggat ggcatctgga caacttattt tgacgttagc
     2941 agttctagct atacttataa ctgcacctct tggagctttt ggaattgatg taacttataa
     3001 aaaattatta acttctgtaa aaggcgagaa taagtaaaaa taaagattat tttaactggt
     3061 aagttatatt ttggaaaagg attatactat tgaatacaat ataaaaaaat catttgggag
     3121 attaagaagg tagaagttaa gaacagattt taaggtatgt tatgattatt agaattgatt
     3181 ttgtgaaatt attattgtaa tatttaatta tatagataaa gaagcggagt gataactatg
     3241 tgtttaaaaa aattatcaaa attagagtta gttattatga aatttatttg gaatttagat
     3301 ataaaaacca attcatatga gattattgat tatatgaaag aagaacataa tttaccagaa
     3361 aaagtagctt taaaaacttt atcaaaacta tcaaagaaaa gattcttata tgttcaagaa
     3421 acaggcaagt gtatgtatta tacagttgca ataaaagaaa aggcatattt agagtttata
     3481 tcaagaaatg tgcaaaatct tttgaagaat aattttataa ggaatttatt agtatcattt
     3541 cacgaagagg agctaacaga ggaaaagata aagtcgttag aaaactgggt agtaaattgg
     3601 gaagaagctt atgtataaat gttattattt ttattacaat ttagataatt ttggttttgt
     3661 aagctctgca actattttta gatggttgca gagtttattt ttatttttta ttcccttaag
     3721 caatacttaa aagtaaacgc atttatattt actaacttca attacttata atacttaaat
     3781 tactttttaa aaatattttg atatgtcatc tctatagtaa tctagaactt gtttctattc
     3841 tttatataaa gtttttatga atgatatata taatattcgt tcatttgatt aaaaataaca
     3901 aaatattaaa taattctact ctgatagttt gttaaaaaaa taataaaaaa tattaataaa
     3961 caaaaaaaaa ttatcttaag agaggagaat gttctaaaat ataaaaaggt ttctagattt
     4021 cataaaagat actattttag tcttgaaaat atttagtttg aaaagatttt aatttaatga
     4081 ttgattaagt taaaaatgtg tatgtaataa attttatttt atttattgac taaattataa
     4141 agtttacata attatttaat aattatgtaa ttgttacttg aaaattgatc tattttaaaa
     4201 tctagttata acttcaaaaa agactgaaaa ttaagaaaaa agaaatataa atataaaaat
     4261 atgtcatata gatttttttt attttacttt aataaaatga tttgttttta caatacttta
     4321 ttaatataaa gtttattgct aaaatacttt atttattaga aaaagattac taattaatta
     4381 ttaaaattaa tgtattcata atgcatattt tcatataaaa tttaatttat ttgccgatta
     4441 tataattata atgactgatt taattccaat gttgtcaaaa ttttcgaata aatcatcatt
     4501 ataaatataa gagaggatga ttttatgcaa aagtcttttt atgaattaat tgttttagca
     4561 agaaataact cagtagatga tttgcaagaa attttattta tgtttaagcc attagtaaaa
     4621 aaacttagta gagttttaca ttatgaagag ggagaaacag atttaataat attttttatt
     4681 gaattaataa aaaatattaa attaagtagc ttttcagaaa aaagcgatgc tattatagtc
     4741 aaatatattc ataaatcatt actgaataag acttttgagt tgtctagaag atattctaaa
     4801 atgaagttta attttgtaga atttgatgaa aatatcttaa atatgaaaaa taattatcaa
     4861 agtaagtctg tttttgagga agatatttgt tttttcgaat atattttgaa agaattatct
     4921 ggtattcaaa gaaaagttat tttttataaa tatttaaaag gatattctga tagagaaata
     4981 tcagtgaaat taaaaatatc tagacaagct gttaataagg ctaaaaatag agcatttaaa
     5041 aaaataaaaa aagactatga aaattatttt aacttgtaat taatgagctt aaagaaatat
     5101 ttacaataga aatcaaattt tagaattaac tttattgtaa aatcaataac ttaatctaag
     5161 aatatcttaa tttttatatt ttatatagaa caaagtttac atatttattt cagacaacgt
     5221 ctttattcaa tcgaagagca aattaatcaa ctgagtgtct tcaatttaaa atgttaggaa
     5281 gtgaatgtat atgaaaacct aagtagatat tagtatattt tataaataga aaggaggata
     5341 tataaaagag ttttatcatt tagatgtaaa aatattatag taaaggagaa aattttatga
     5401 gtttagttaa tagaaaacag ttagaaaaaa tggcaaatgt aagatttcgt actcaagaag
     5461 atgaatatgt tgcaatattg gatgctttag aagaatatca taatatgtca gagaatactg
     5521 tagtcgaaaa atatttaaaa ttaaaagata taaatagttt aacagatatt tatatagata
     5581 catataaaaa atctggtaga aataaagcct taaaaaaatt taaggaatat ctagttacag
     5641 aagtattaga gctaaagaat aataatttaa ctccagttga gaaaaattta cattttgttt
     5701 ggattggagg tcaaataaat gacactgcta ttaattatat aaatcaatgg aaagatgtaa
     5761 atagtgatta taatgttaat gttttttatg atagtaatgc atttttgata aacacattga
     5821 aaaaaactgt agtagaatca gcaataaatg atacacttga atcatttaga gaaaacttaa
     5881 atgaccctag atttgactat aataaattct tcagaaaacg tatggaaata atttatgata
     5941 aacagaaaaa tttcataaac tactataaag ctcaaagaga agaaaatcct gaacttataa
     6001 ttgatgatat tgtaaagaca tatctttcaa atgagtattc aaaggagata gatgaactta
     6061 atacctatat tgaagaatcc ttaaataaaa ttacacagaa tagtggaaat gatgttagaa
     6121 actttgaaga atttaaaaat ggagagtcat tcaacttata tgaacaagag ttggtagaaa
     6181 ggtggaattt agctgctgct tctgacatat taagaatatc tgcattaaaa gaaattggtg
     6241 gtatgtattt agatgttgat atgttaccag gaatacaacc agacttattt gagtctatag
     6301 agaaacctag ttcagtaaca gtggattttt gggaaatgac aaagttagaa gctataatga
     6361 aatacaaaga atatatacca gaatatacct cagaacattt tgacatgtta gacgaagaag
     6421 ttcaaagtag ttttgaatct gttctagctt ctaagtcaga taaatcagaa atattctcat
     6481 cacttggtga tatggaggca tcaccactag aagttaaaat tgcatttaat agtaagggta
     6541 ttataaatca agggctaatt tctgtgaaag actcatattg tagcaattta atagtaaaac
     6601 aaatcgagaa tagatataaa atattgaata atagtttaaa tccagctatt agcgaggata
     6661 atgattttaa tactacaacg aataccttta ttgatagtat aatggctgaa gctaatgcag
     6721 ataatggtag atttatgatg gaactaggaa agtatttaag agttggtttc ttcccagatg
     6781 ttaaaactac tattaactta agtggccctg aagcatatgc ggcagcttat caagatttat
     6841 taatgtttaa agaaggcagt atgaatatcc atttgataga agctgattta agaaactttg
     6901 aaatctctaa aactaatatt tctcaatcaa ctgaacaaga aatggctagc ttatggtcat
     6961 ttgacgatgc aagagctaaa gctcaatttg aagaatataa aaggaattat tttgaaggtt
     7021 ctcttggtga agatgataat cttgattttt ctcaaaatat agtagttgac aaggagtatc
     7081 ttttagaaaa aatatcttca ttagcaagaa gttcagagag aggatatata cactatattg
     7141 ttcagttaca aggagataaa attagttatg aagcagcatg taacttattt gcaaagactc
     7201 cttatgatag tgtactgttt cagaaaaata tagaagattc agaaattgca tattattata
     7261 atcctggaga tggtgaaata caagaaatag acaagtataa aattccaagt ataatttctg
     7321 atagacctaa gattaaatta acatttattg gtcatggtaa agatgaattt aatactgata
     7381 tatttgcagg ttttgatgta gattcattat ccacagaaat agaagcagca atagatttag
     7441 ctaaagagga tatttctcct aagtcaatag aaataaattt attaggatgt aatatgttta
     7501 gctactctat caacgtagag gagacttatc ctggaaaatt attacttaaa gttaaagata
     7561 aaatatcaga attaatgcca tctataagtc aagactctat tatagtaagt gcaaatcaat
     7621 atgaagttag aataaatagt gaaggaagaa gagaattatt agaccattct ggtgaatgga
     7681 taaacaaaga agaaagtatt ataaaggata tttcatcaaa agaatatata tcatttaatc
     7741 ctaaagaaaa taaaattaca gtaaaatcta aaaatttacc tgagctatct acattattac
     7801 aagaaattag aaataattct aattcaagtg atattgaact agaagaaaaa gtaatgttaa
     7861 cagaatgtga gataaatgtt atttcaaata tagatacgca aattgttgag gaaaggattg
     7921 aagaagctaa gaatttaact tctgactcta ttaattatat aaaagatgaa tttaaactaa
     7981 tagaatctat ttctgatgca ctatgtgact taaaacaaca gaatgaatta gaagattctc
     8041 attttatatc ttttgaggac atatcagaga ctgatgaggg atttagtata agatttatta
     8101 ataaagaaac tggagaatct atatttgtag aaactgaaaa aacaatattc tctgaatatg
     8161 ctaatcatat aactgaagag atttctaaga taaaaggtac tatatttgat actgtaaatg
     8221 gtaagttagt aaaaaaagta aatttagata ctacacacga agtaaatact ttaaatgctg
     8281 cattttttat acaatcatta atagaatata atagttctaa agaatctctt agtaatttaa
     8341 gtgtagcaat gaaagtccaa gtttacgctc aattatttag tactggttta aatactatta
     8401 cagatgcagc caaagttgtt gaattagtat caactgcatt agatgaaact atagacttac
     8461 ttcctacatt atctgaagga ttacctataa ttgcaactat tatagatggt gtaagtttag
     8521 gtgcagcaat caaagagcta agtgaaacga gtgacccatt attaagacaa gaaatagaag
     8581 ctaagatagg tataatggca gtaaatttaa caacagctac aactgcaatc attacttcat
     8641 ctttggggat agctagtgga tttagtatac ttttagttcc tttagcagga atttcagcag
     8701 gtataccaag cttagtaaac aatgaacttg tacttcgaga taaggcaaca aaggttgtag
     8761 attattttaa acatgtttca ttagttgaaa ctgaaggagt atttacttta ttagatgata
     8821 aaataatgat gccacaagat gatttagtga tatcagaaat agattttaat aataattcaa
     8881 tagttttagg taaatgtgaa atctggagaa tggaaggtgg ttcaggtcat actgtaactg
     8941 atgatataga tcacttcttt tcagcaccat caataacata tagagagcca cacttatcta
     9001 tatatgacgt attggaagta caaaaagaag aacttgattt gtcaaaagat ttaatggtat
     9061 tacctaatgc tccaaataga gtatttgctt gggaaacagg atggacacca ggtttaagaa
     9121 gcttagaaaa tgatggcaca aaactgttag accgtataag agataactat gaaggtgagt
     9181 tttattggag atattttgct tttatagctg atgctttaat aacaacatta aaaccaagat
     9241 atgaagatac taatataaga ataaatttag atagtaatac tagaagtttt atagttccaa
     9301 taataactac agaatatata agagaaaaat tatcatattc tttctatggt tcaggaggaa
     9361 cttatgcatt gtctctttct caatataata tgggtataaa tatagaatta agtgaaagtg
     9421 atgtttggat tatagatgtt gataatgttg tgagagatgt aactatagaa tctgataaaa
     9481 ttaaaaaagg tgatttaata gaaggtattt tatctacact aagtattgaa gagaataaaa
     9541 ttatcttaaa tagccatgag attaattttt ctggtgaggt aaatggaagt aatggatttg
     9601 tttctttaac attttcaatt ttagaaggaa taaatgcaat tatagaagtt gatttattat
     9661 ctaaatcata taaattactt atttctggcg aattaaaaat attgatgtta aattcaaatc
     9721 atattcaaca gaaaatagat tatataggat tcaatagcga attacagaaa aatataccat
     9781 atagctttgt agatagtgaa ggaaaagaga atggttttat taatggttca acaaaagaag
     9841 gtttatttgt atctgaatta cctgatgtag ttcttataag taaggtttat atggatgata
     9901 gtaagccttc atttggatat tatagtaata atttgaaaga tgtcaaagtt ataactaaag
     9961 ataatgttaa tatattaaca ggttattatc ttaaggatga tataaaaatc tctctttctt
    10021 tgactctaca agatgaaaaa actataaagt taaatagtgt gcatttagat gaaagtggag
    10081 tagctgagat tttgaagttc atgaatagaa aaggtaatac aaatacttca gattctttaa
    10141 tgagcttttt agaaagtatg aatataaaaa gtattttcgt taatttctta caatctaata
    10201 ttaagtttat attagatgct aattttataa taagtggtac tacttctatt ggccaatttg
    10261 agtttatttg tgatgaaaat gataatatac aaccatattt cattaagttt aatacactag
    10321 aaactaatta tactttatat gtaggaaata gacaaaatat gatagtggaa ccaaattatg
    10381 atttagatga ttctggagat atatcttcaa ctgttatcaa tttctctcaa aagtatcttt
    10441 atggaataga cagttgtgtt aataaagttg taatttcacc aaatatttat acagatgaaa
    10501 taaatataac gcctgtatat gaaacaaata atacttatcc agaagttatt gtattagatg
    10561 caaattatat aaatgaaaaa ataaatgtta atatcaatga tctatctata cgatatgtat
    10621 ggagtaatga tggtaatgat tttattctta tgtcaactag tgaagaaaat aaggtgtcac
    10681 aagttaaaat aagattcgtt aatgttttta aagataagac tttggcaaat aagctatctt
    10741 ttaactttag tgataaacaa gatgtacctg taagtgaaat aatcttatca tttacacctt
    10801 catattatga ggatggattg attggctatg atttgggtct agtttcttta tataatgaga
    10861 aattttatat taataacttt ggaatgatgc tatctggatt aatatatatt aatgattcat
    10921 tatattattt taaaccacca gtaaataatt tgataactgg atttgtgact gtaggcgatg
    10981 ataaatacta ctttaatcca attaatggtg gagctgcttc aattggagag acaataattg
    11041 atgacaaaaa ttattatttc aaccaaagtg gagtgttaca aacaggtgta tttagtacag
    11101 aagatggatt taaatatttt gccccagcta atacacttga tgaaaaccta gaaggagaag
    11161 caattgattt tactggaaaa ttaattattg acgaaaatat ttattatttt gatgataatt
    11221 atagaggagc tgtagaatgg aaagaattag atggtgaaat gcactatttt agcccagaaa
    11281 caggtaaagc ttttaaaggt ctaaatcaaa taggtgatga taaatactat ttcaattctg
    11341 atggagttat gcaaaaagga tttgttagta taaatgataa taaacactat tttgatgatt
    11401 ctggtgttat gaaagtaggt tacactgaaa tagatggcaa gcatttctac tttgctgaaa
    11461 acggagaaat gcaaatagga gtatttaata cagaagatgg atttaaatat tttgctcatc
    11521 ataatgaaga tttaggaaat gaagaaggtg aagaaatctc atattctggt atattaaatt
    11581 tcaataataa aatttactat tttgatgatt catttacagc tgtagttgga tggaaagatt
    11641 tagaggatgg ttcaaagtat tattttgatg aagatacagc agaagcatat ataggtttgt
    11701 cattaataaa tgatggtcaa tattatttta atgatgatgg aattatgcaa gttggatttg
    11761 tcactataaa tgataaagtc ttctacttct ctgactctgg aattatagaa tctggagtac
    11821 aaaacataga tgacaattat ttctatatag atgataatgg tatagttcaa attggtgtat
    11881 ttgatacttc agatggatat aaatattttg cacctgctaa tactgtaaat gataatattt
    11941 acggacaagc agttgaatat agtggtttag ttagagttgg ggaagatgta tattattttg
    12001 gagaaacata tacaattgag actggatgga tatatgatat ggaaaatgaa agtgataaat
    12061 attatttcaa tccagaaact aaaaaagcat gcaaaggtat taatttaatt gatgatataa
    12121 aatattattt tgatgagaag ggcataatga gaacgggtct tatatcattt gaaaataata
    12181 attattactt taatgagaat ggtgaaatgc aatttggtta tataaatata gaagataaga
    12241 tgttctattt tggtgaagat ggtgtcatgc agattggagt atttaataca ccagatggat
    12301 ttaaatactt tgcacatcaa aatactttgg atgagaattt tgagggagaa tcaataaact
    12361 atactggttg gttagattta gatgaaaaga gatattattt tacagatgaa tatattgcag
    12421 caactggttc agttattatt gatggtgagg agtattattt tgatcctgat acagctcaat
    12481 tagtgattag tgaatagata aaaatatgtt aaatatatcc tcttatactt aaatatataa
    12541 aaataaacaa aatgatacac tacataaagt gttctatcta atatgaagat ttaccaataa
    12601 aaaggtggac tatgatgaat gcacagtagt tcaccttttt atatttctaa tggtaacaaa
    12661 atattttttt atataaacct aggaggcgtt atgaatatga caatatcttt tttatcagag
    12721 catatattta taaagttagt aattttaact atatcatttg atacattatt aggatgttta
    12781 agtgcaataa aaagtcgtaa atttaattct agttttggaa tagatggagg aatcagaaaa
    12841 gtagcaatga tagcatgtat atttttttta tcagtagttg acattcttac aaagtttaac
    12901 tttttattta tgttaccaca agattgtatc aattttttaa gactaaaaca tcttggaata
    12961 tctgaatttt tctctatttt atttatttta tatgaaagtg taagtatatt aaaaaatatg
    13021 tgcttatgtg gattaccagt acctaagaga ttaaaggaaa aaatagcaat tttactagat
    13081 gcaatgacag atgaaatgaa tgctaaggat gaaaagtaag taatggtaga tataataaag
    13141 atattaacaa ataaaaagtg ttatccaaat aagaatagct gaaagttatc ataattcatg
    13201 aaactaataa tgaaaacgag ggagcagatg ccaagagaca cacaagtatt aaatacatat
    13261 aatttcgaag caagtgttca ttactatata gatgacaagg tagtatatca aacattggtt
    13321 cacaaagatg gtgcatggtc agttggtaaa atctattaag ctacattagt tacagatatc
    13381 acaaactata atagttaaac atagaaatat gtgtaaattg tgatggaaat tattcaaaaa
    13441 cacaaaaata cgtgatgaag gacaaaatga tatagaaaat aagtatcaaa ccttaataaa
    13501 tgatttaatt gatagtttaa aagttatagg aaaaatatat aaagaaataa aaacattaaa
    13561 aaaatataag atatgtttac aaattactat cagacaatct ccttatctaa tagaagagtc
    13621 aattaactaa ttgagtatct ttaaattgaa atgttaggaa gtgatttaaa tatgaaaact
    13681 taaattataa aaaatcaata ttaatttatt tttaaaaaat agaaaggagt gtataagatt
    13741 tattttcaaa gtttaaaaac aagaaaatca atttaaattt cagaaggaat aaatgtggtt
    13801 atagaagtgg atttattatc aaaaataata atactaggag gtttttatgt ctttaatatc
    13861 taaagaagag ttaataaaac tcgcatatag cattagacca agagaaaatg agtataaaac
    13921 tatactaact aatttagacg aatataataa gttaactaca aacaataatg aaaataaata
    13981 tttacaatta aaaaaactaa atgaatcaat tgatgttttt atgaataaat ataaaacttc
    14041 aagcagaaat agagcactct ctaatctaaa aaaagatata ttaaaagaag taattcttat
    14101 taaaaattcc aatacaagcc ctgtagaaaa aaatttacat tttgtatgga taggtggaga
    14161 agtcagtgat attgctcttg aatacataaa acaatgggct gatattaatg cagaatataa
    14221 tattaaactg tggtatgata gtgaagcatt cttagtaaat acactaaaaa aggctatagt
    14281 tgaatcttct accactgaag cattacagct actagaggaa gagattcaaa atcctcaatt
    14341 tgataatatg aaattttaca aaaaaaggat ggaatttata tatgatagac aaaaaaggtt
    14401 tataaattat tataaatctc aaatcaataa acctacagta cctacaatag atgatattat
    14461 aaagtctcat ctagtatctg aatataatag agatgaaact gtattagaat catatagaac
    14521 aaattctttg agaaaaataa atagtaatca tgggatagat atcagggcta atagtttgtt
    14581 tacagaacaa gagttattaa atatttatag tcaggagttg ttaaatcgtg gaaatttagc
    14641 tgcagcatct gacatagtaa gattattagc cctaaaaaat tttggcggag tatatttaga
    14701 tgttgatatg cttccaggta ttcactctga tttatttaaa acaatatcta gacctagctc
    14761 tattggacta gaccgttggg aaatgataaa attagaggct attatgaagt ataaaaaata
    14821 tataaataat tatacatcag aaaactttga taaacttgat caacaattaa aagataattt
    14881 taaactcatt atagaaagta aaagtgaaaa atctgagata ttttctaaat tagaaaattt
    14941 aaatgtatct gatcttgaaa ttaaaatagc tttcgcttta ggcagtgtta taaatcaagc
    15001 cttgatatca aaacaaggtt catatcttac taacctagta atagaacaag taaaaaatag
    15061 atatcaattt ttaaaccaac accttaaccc agccatagag tctgataata acttcacaga
    15121 tactactaaa atttttcatg attcattatt taattcagct accgcagaaa actctatgtt
    15181 tttaacaaaa atagcaccat acttacaagt aggttttatg ccagaagctc gctccacaat
    15241 aagtttaagt ggtccaggag cttatgcgtc agcttactat gatttcataa atttacaaga
    15301 aaatactata gaaaaaactt taaaagcatc agatttaata gaatttaaat tcccagaaaa
    15361 taatctatct caattgacag aacaagaaat aaatagtcta tggagctttg atcaagcaag
    15421 tgcaaaatat caatttgaga aatatgtaag agattatact ggtggatctc tttctgaaga
    15481 caatggggta gactttaata aaaatactgc cctcgacaaa aactatttat taaataataa
    15541 aattccatca aacaatgtag aagaagctgg aagtaaaaat tatgttcatt atatcataca
    15601 gttacaagga gatgatataa gttatgaagc aacatgcaat ttattttcta aaaatcctaa
    15661 aaatagtatt attatacaac gaaatatgaa tgaaagtgca aaaagctact ttttaagtga
    15721 tgatggagaa tctattttag aattaaataa atataggata cctgaaagat taaaaaataa
    15781 ggaaaaagta aaagtaacct ttattggaca tggtaaagat gaattcaaca caagcgaatt
    15841 tgctagatta agtgtagatt cactttccaa tgagataagt tcatttttag ataccataaa
    15901 attagatata tcacctaaaa atgtagaagt aaacttactt ggatgtaata tgtttagtta
    15961 tgattttaat gttgaagaaa cttatcctgg gaagttgcta ttaagtatta tggacaaaat
    16021 tacttccact ttacctgatg taaataaaaa ttctattact ataggagcaa atcaatatga
    16081 agtaagaatt aatagtgagg gaagaaaaga acttctggct cactcaggta aatggataaa
    16141 taaagaagaa gctattatga gcgatttatc tagtaaagaa tacatttttt ttgattctat
    16201 agataataag ctaaaagcaa agtccaagaa tattccagga ttagcatcaa tatcagaaga
    16261 tataaaaaca ttattacttg atgcaagtgt tagtcctgat acaaaattta ttttaaataa
    16321 tcttaagctt aatattgaat cttctattgg tgattacatt tattatgaaa aattagagcc
    16381 tgttaaaaat ataattcaca attctataga tgatttaata gatgagttca atctacttga
    16441 aaatgtatct gatgaattat atgaattaaa aaaattaaat aatctagatg agaagtattt
    16501 aatatctttt gaagatatct caaaaaataa ttcaacttac tctgtaagat ttattaacaa
    16561 aagtaatggt gagtcagttt atgtagaaac agaaaaagaa attttttcaa aatatagcga
    16621 acatattaca aaagaaataa gtactataaa gaatagtata attacagatg ttaatggtaa
    16681 tttattggat aatatacagt tagatcatac ttctcaagtt aatacattaa acgcagcatt
    16741 ctttattcaa tcattaatag attatagtag caataaagat gtactgaatg atttaagtac
    16801 ctcagttaag gttcaacttt atgctcaact atttagtaca ggtttaaata ctatatatga
    16861 ctctatccaa ttagtaaatt taatatcaaa tgcagtaaat gatactataa atgtactacc
    16921 tacaataaca gaggggatac ctattgtatc tactatatta gacggaataa acttaggtgc
    16981 agcaattaag gaattactag acgaacatga cccattacta aaaaaagaat tagaagctaa
    17041 ggtgggtgtt ttagcaataa atatgtcatt atctatagct gcaactgtag cttcaattgt
    17101 tggaataggt gctgaagtta ctattttctt attacctata gctggtatat ctgcaggaat
    17161 accttcatta gttaataatg aattaatatt gcatgataag gcaacttcag tggtaaacta
    17221 ttttaatcat ttgtctgaat ctaaaaaata tggccctctt aaaacagaag atgataaaat
    17281 tttagttcct attgatgatt tagtaatatc agaaatagat tttaataata attcgataaa
    17341 actaggaaca tgtaatatat tagcaatgga ggggggatca ggacacacag tgactggtaa
    17401 tatagatcac tttttctcat ctccatctat aagttctcat attccttcat tatcaattta
    17461 ttctgcaata ggtatagaaa cagaaaatct agatttttca aaaaaaataa tgatgttacc
    17521 taatgctcct tcaagagtgt tttggtggga aactggagca gttccaggtt taagatcatt
    17581 ggaaaatgac ggaactagat tacttgattc aataagagat ttatacccag gtaaatttta
    17641 ctggagattc tatgcttttt tcgattatgc aataactaca ttaaaaccag tttatgaaga
    17701 cactaatatt aaaattaaac tagataaaga tactagaaac ttcataatgc caactataac
    17761 tactaacgaa attagaaaca aattatctta ttcatttgat ggagcaggag gaacttactc
    17821 tttattatta tcttcatatc caatatcaac gaatataaat ttatctaaag atgatttatg
    17881 gatatttaat attgataatg aagtaagaga aatatctata gaaaatggta ctattaaaaa
    17941 aggaaagtta ataaaagatg ttttaagtaa aattgatata aataaaaata aacttattat
    18001 aggcaatcaa acaatagatt tttcaggcga tatagataat aaagatagat atatattctt
    18061 gacttgtgag ttagatgata aaattagttt aataatagaa ataaatcttg ttgcaaaatc
    18121 ttatagtttg ttattgtctg gggataaaaa ttatttgata tccaatttat ctaatactat
    18181 tgagaaaatc aatactttag gcctagatag taaaaatata gcgtacaatt acactgatga
    18241 atctaataat aaatattttg gagctatatc taaaacaagt caaaaaagca taatacatta
    18301 taaaaaagac agtaaaaata tattagaatt ttataatgac agtacattag aatttaacag
    18361 taaagatttt attgctgaag atataaatgt atttatgaaa gatgatatta atactataac
    18421 aggaaaatac tatgttgata ataatactga taaaagtata gatttctcta tttctttagt
    18481 tagtaaaaat caagtaaaag taaatggatt atatttaaat gaatccgtat actcatctta
    18541 ccttgatttt gtgaaaaatt cagatggaca ccataatact tctaatttta tgaatttatt
    18601 tttggacaat ataagtttct ggaaattgtt tgggtttgaa aatataaatt ttgtaatcga
    18661 taaatacttt acccttgttg gtaaaactaa tcttggatat gtagaattta tttgtgacaa
    18721 taataaaaat atagatatat attttggtga atggaaaaca tcgtcatcta aaagcactat
    18781 atttagcgga aatggtagaa atgttgtagt agagcctata tataatcctg atacgggtga
    18841 agatatatct acttcactag atttttccta tgaacctctc tatggaatag atagatatat
    18901 caataaagta ttgatagcac ctgatttata tacaagttta ataaatatta ataccaatta
    18961 ttattcaaat gagtactacc ctgagattat agttcttaac ccaaatacat tccacaaaaa
    19021 agtaaatata aatttagata gttcttcttt tgagtataaa tggtctacag aaggaagtga
    19081 ctttatttta gttagatact tagaagaaag taataaaaaa atattacaaa aaataagaat
    19141 caaaggtatc ttatctaata ctcaatcatt taataaaatg agtatagatt ttaaagatat
    19201 taaaaaacta tcattaggat atataatgag taattttaaa tcatttaatt ctgaaaatga
    19261 attagataga gatcatttag gatttaaaat aatagataat aaaacttatt actatgatga
    19321 agatagtaaa ttagttaaag gattaatcaa tataaataat tcattattct attttgatcc
    19381 tatagaattt aacttagtaa ctggatggca aactatcaat ggtaaaaaat attattttga
    19441 tataaatact ggagcagctt taactagtta taaaattatt aatggtaaac acttttattt
    19501 taataatgat ggtgtgatgc agttgggagt atttaaagga cctgatggat ttgaatattt
    19561 tgcacctgcc aatactcaaa ataataacat agaaggtcag gctatagttt atcaaagtaa
    19621 attcttaact ttgaatggca aaaaatatta ttttgataat gactcaaaag cagtcactgg
    19681 atggagaatt attaacaatg agaaatatta ctttaatcct aataatgcta ttgctgcagt
    19741 cggattgcaa gtaattgaca ataataagta ttatttcaat cctgacactg ctatcatctc
    19801 aaaaggttgg cagactgtta atggtagtag atactacttt gatactgata ccgctattgc
    19861 ctttaatggt tataaaacta ttgatggtaa acacttttat tttgatagtg attgtgtagt
    19921 gaaaataggt gtgtttagta cctctaatgg atttgaatat tttgcacctg ctaatactta
    19981 taataataac atagaaggtc aggctatagt ttatcaaagt aaattcttaa ctttgaatgg
    20041 taaaaaatat tactttgata ataactcaaa agcagttacc ggatggcaaa ctattgatag
    20101 taaaaaatat tactttaata ctaacactgc tgaagcagct actggatggc aaactattga
    20161 tggtaaaaaa tattacttta atactaacac tgctatagct tcaactggtt atacaattat
    20221 taatggtaaa catttttatt ttaatactga tggtattatg cagataggag tgtttaaagg
    20281 acctaatgga tttgaatatt ttgcacctgc taatacggat gctaacaaca tagaaggtca
    20341 agctatactt taccaaaatg aattcttaac tttgaatggt aaaaaatatt actttggtag
    20401 tgactcaaaa gcagttactg gatggagaat tattaacaat aagaaatatt actttaatcc
    20461 taataatgct attgctgcaa ttcatctatg cactataaat aatgacaagt attactttag
    20521 ttatgatgga attcttcaaa atggatatat tactattgaa agaaataatt tctattttga
    20581 tgctaataat gaatctaaaa tggtaacagg agtatttaaa ggacctaatg gatttgagta
    20641 ttttgcacct gctaatactc acaataataa catagaaggt caggctatag tttaccagaa
    20701 caaattctta actttgaatg gcaaaaaata ttattttgat aatgactcaa aagcagttac
    20761 tggatggcaa ac
//
LOCUS       DAEQCW010000068        20716 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.068, whole genome shotgun sequence.
ACCESSION   DAEQCW010000068 DAEQCW010000000
VERSION     DAEQCW010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20716)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20716)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20716
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.068"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            370..681
                     /gene="rpsJ"
                     /locus_tag="KRO40_002398"
     CDS             370..681
                     /gene="rpsJ"
                     /locus_tag="KRO40_002398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HBH2093215.1"
                     /translation="MAKNEKIRIRLKSYDHKLLDFSAGKIVETAKKAGSQVSGPVPLP
                     TEKQVVTILRAVHKYKDSREQFEIRTHKRLIDIANPTPKTVDSLMRLDLPAGVDIEIK
                     L"
     gene            773..1402
                     /gene="rplC"
                     /locus_tag="KRO40_002399"
     CDS             773..1402
                     /gene="rplC"
                     /locus_tag="KRO40_002399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HBH2093216.1"
                     /translation="MKGILGKKVGMTQIFTDKGVVIPVTAVEAGPMVVTQIKTVDKDG
                     YNAIQIGFEDAKEKALNKPKKGHLAAANVLKKHLKEFRVDSVEGYTVGQEIKADVFEA
                     GAKIDVTGISKGKGFQGPIKRHGQSRGPETHGSRYHRRPGSMGACSYPGRVFKNKKLA
                     GHMGSVKVTVQNLEVVKVDADKNLILVKGAIPGAKGSVVTIKEAIKVSK"
     gene            1432..2055
                     /gene="rplD"
                     /locus_tag="KRO40_002400"
     CDS             1432..2055
                     /gene="rplD"
                     /locus_tag="KRO40_002400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001127258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HBH2093217.1"
                     /translation="MPKLNVLNVSGQNVGEIELSDSIFGVEVNGHVLYEVVKNQLANK
                     RQGTQSAKTRAEVRGGGRKPWKQKGTGRARQGSTRSVQWVGGGVAFAPKPRSYKYTLP
                     KKVRRLAMKSALSSKVQNSEVIVLDALNMDAPKTKEFAQILNNINAAKKALVVIADKN
                     DNVIKSARNIEGVQTALVNTMNVYDILKYDSFIITTDAVKKVEEVYA"
     gene            2055..2345
                     /gene="rplW"
                     /locus_tag="KRO40_002401"
     CDS             2055..2345
                     /gene="rplW"
                     /locus_tag="KRO40_002401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HBH2093218.1"
                     /translation="MTNPHDVIIRPVVTEHSMAEMGEKKYTFVVAKDANKTEIKKAVE
                     KVFGVSVDKVNTLNYDGKVKRMGRTQGRTSSFKKAVVKLTADSKEIEFFQGM"
     gene            2375..3205
                     /gene="rplB"
                     /locus_tag="KRO40_002402"
     CDS             2375..3205
                     /gene="rplB"
                     /locus_tag="KRO40_002402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HBH2093219.1"
                     /translation="MAIKKFRPTSPALRQMTVLVSDEITCNQPEKSLLVNLKKNAGRN
                     VHGRITVRHRGGGQKRKYRIIDFKRDKDGIPAKVATIEYDPNRTANIALLNYADGEKR
                     YILAPVGINVGDTILSGLGADIKPGNCLALKDMPVGTIIHNIELKPGKGAQLVRSAGV
                     SAQLMAKEGKNALLRLPSGEMRLVSINCKATIGQVGNIEHGNVVIGKAGRKRHMGIRP
                     TVRGSVMNPNDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKKNKASNKLIVSRRTK
                     "
     gene            3240..3521
                     /gene="rpsS"
                     /locus_tag="KRO40_002403"
     CDS             3240..3521
                     /gene="rpsS"
                     /locus_tag="KRO40_002403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HBH2093220.1"
                     /translation="MSRSTKKGPFVHARLLKKIEAMNASGNKEVIKTWSRSSTVFPQM
                     VENTIAVHDGRKHVPVYITEDMVGHKLGEFVPTRTFKGHKDDEKSNKRK"
     gene            3553..3888
                     /gene="rplV"
                     /locus_tag="KRO40_002404"
     CDS             3553..3888
                     /gene="rplV"
                     /locus_tag="KRO40_002404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HBH2093221.1"
                     /translation="MEAKATAKYVRVSPRKAGQICDLVRGKNVDEALAILKFTPRGAA
                     SIIAKVVKSAKANAENNHEMDTEKLYIASIVANQGPTMKRFMPRAMGRATTIRKRTSH
                     IEVVVKEKK"
     gene            3911..4726
                     /gene="rpsC"
                     /locus_tag="KRO40_002405"
     CDS             3911..4726
                     /gene="rpsC"
                     /locus_tag="KRO40_002405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HBH2093222.1"
                     /translation="MGQKVNPHGLRVGVIKDWDSRWFATDKKEFGNLLLEDHNIRKFL
                     KKRLYSAGVAKIEIERSANKIKMDLHVAKPGVVIGRAGAGIEALKAELEKMTKKTIIV
                     NIVEVRSTDKNAQLVAENIALAIERRVAFRRAMKQAIQRAMKSGAKGIKVSASGRLGG
                     AEMARTEGYSEGNVPLQTLRADIDYGFAEADTTYGKIGIKVWICNGEVLPTRDGVNPR
                     EESRKSDRRDNKRDNRRNDRRGNDRRGNDNRGNYRGQRPQGGSRPQRTENKGN"
     gene            4762..5193
                     /gene="rplP"
                     /locus_tag="KRO40_002406"
     CDS             4762..5193
                     /gene="rplP"
                     /locus_tag="KRO40_002406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HBH2093223.1"
                     /translation="MLMPKRVKRRRVHRGSMAGQAHKGNKVTYGEFGLVALEASWITS
                     NQIEAARIAMTRYIKRGGKVWIKIFPHKPVTRKPAETRMGAGKGSPEYWVAVVKPGRV
                     MFELAGVSEDKAREAMRLAAHKLPIKCKFVKKEDLEVKGGE"
     gene            5195..5398
                     /gene="rpmC"
                     /locus_tag="KRO40_002407"
     CDS             5195..5398
                     /gene="rpmC"
                     /locus_tag="KRO40_002407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HBH2093224.1"
                     /translation="MKAKELRDLTSEELMNKLNDFKSELFSLRFQLATGQLENTARIK
                     FVKKDIAKVKTVLAERKLYETRA"
     gene            5422..5676
                     /gene="rpsQ"
                     /locus_tag="KRO40_002408"
     CDS             5422..5676
                     /gene="rpsQ"
                     /locus_tag="KRO40_002408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HBH2093225.1"
                     /translation="MERGRRKVRIGRVVSDKMDKTIVVAVEEFVRHPLYNKRVKRTKK
                     FKAHDEKNICNIGDRVKIMETRPLSKDKRFRLVEVVEKVK"
     gene            5702..6070
                     /gene="rplN"
                     /locus_tag="KRO40_002409"
     CDS             5702..6070
                     /gene="rplN"
                     /locus_tag="KRO40_002409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007885948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HBH2093226.1"
                     /translation="MIQQESRLRVADNSGAKELLCIRVLGGSKRRYGNIGDVIVATVK
                     SATPGGVVKKGKVVKAVIVRSKQGVRRNDGSYISFDENAAVIIKDDKTPVGTRIFGPV
                     ARELRDNEFMKIVSLAPEVL"
     gene            6094..6399
                     /gene="rplX"
                     /locus_tag="KRO40_002410"
     CDS             6094..6399
                     /gene="rplX"
                     /locus_tag="KRO40_002410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HBH2093227.1"
                     /translation="MRVKKGDTVVVIAGKDKGKKGSVLKVYPKTSKVLVEGVNVITKH
                     QKPSAMNQQGGIINKEAPIHISNVMPFDPETGKGVRVRYEVKDGNKVRVSAKSGKEL"
     gene            6429..6971
                     /gene="rplE"
                     /locus_tag="KRO40_002411"
     CDS             6429..6971
                     /gene="rplE"
                     /locus_tag="KRO40_002411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HBH2093228.1"
                     /translation="MASRLQEKYMKEVAPALMEKFGYKNVMEIPKLNKIVINMGIGDA
                     RENPKGLEKGVEELEMISGQKPVITKARKSVANFKLREGMPIGTKVTLRADKMFYFMD
                     KLVSVSLPRVRDFRGVNPNAFDGRGNYALGVKEQLIFPEIEYDKIDKVRGMDIIFVTT
                     AKTDEEARELLKLLGMPFSK"
     gene            6989..7174
                     /locus_tag="KRO40_002412"
     CDS             6989..7174
                     /locus_tag="KRO40_002412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type Z 30S ribosomal protein S14"
                     /protein_id="HBH2093229.1"
                     /translation="MARKAMVVKQQRKQKYATREYTRCTICGRPHSVLKKFGICRICF
                     RELAYKGQIPGVRKASW"
     gene            7207..7605
                     /gene="rpsH"
                     /locus_tag="KRO40_002413"
     CDS             7207..7605
                     /gene="rpsH"
                     /locus_tag="KRO40_002413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HBH2093230.1"
                     /translation="MTMTDPIADMLTRIRNANVVKHETVDVPASNMKKELARILLEEG
                     FIRGYDVIEDGKQGIIRIQLKYGQEGERVITGLKKISKPGMRVYAANHEIPKVLNGLG
                     ISVISTSKGILTDKQARKENVGGEVICYVW"
     gene            7636..8178
                     /gene="rplF"
                     /locus_tag="KRO40_002414"
     CDS             7636..8178
                     /gene="rplF"
                     /locus_tag="KRO40_002414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HBH2093231.1"
                     /translation="MSRIGVKPIIIPAGVEVTIAEGNLVTVKGPKGTLTKQLSAELNI
                     KKEENTIMVERPTDNKKHRSLHGLTRTLLDNMVVGVNTGFEKKLELKGVGYRAQKQGK
                     KLVMNLGFSHPVEMEDPEGITVEAPNQTELIVKGIDKQLVGNYAAKIRAWRKPEPYKG
                     KGIKYVDEVIRRKEGKTGKK"
     gene            8214..8582
                     /gene="rplR"
                     /locus_tag="KRO40_002415"
     CDS             8214..8582
                     /gene="rplR"
                     /locus_tag="KRO40_002415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HBH2093232.1"
                     /translation="MLKKADKNANRLQRHKRVRRKISGTSQRPRLCVFRSANNIYAQI
                     IDDTKRVTLVAASSLEAEVKSAVNHTGNKEAAKKVGELVAKKAVEKGITEVVFDRGGY
                     LYHGRIQELAEGAREAGLKF"
     gene            8603..9112
                     /gene="rpsE"
                     /locus_tag="KRO40_002416"
     CDS             8603..9112
                     /gene="rpsE"
                     /locus_tag="KRO40_002416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HBH2093233.1"
                     /translation="MLRRKPIDAGQLDLQEKVVEVRRVTKVVKGGRNFRFAALVVVGD
                     ENGHVGIGAGKAMEVPDAIKKAVEDAKKNLIVVPIVGTTIPHEVRGHFGAGNILIMPA
                     VEGTGVIAGGPARAVLELAGLKDVRAKSLGSNNPRNMVNATIEGLNSLKTVEDIAKLR
                     GKKVEELLG"
     gene            9127..9312
                     /gene="rpmD"
                     /locus_tag="KRO40_002417"
     CDS             9127..9312
                     /gene="rpmD"
                     /locus_tag="KRO40_002417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HBH2093234.1"
                     /translation="MAKLQIKLVRSVIGTTPNQKKNVEALGLRKREQVVVKEDNAQTR
                     GMINKVSHLLEVTEIAE"
     gene            9345..9788
                     /gene="rplO"
                     /locus_tag="KRO40_002418"
     CDS             9345..9788
                     /gene="rplO"
                     /locus_tag="KRO40_002418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HBH2093235.1"
                     /translation="MKLHELKPAEGAVRAKRRLGRGTATGQGKTAGRGQKGQWSRSGG
                     GVRVGFEGGQMPLARRLPKRGFNNIFKKVYTEVNVEVLNRFENGTEITAELLKSTKTI
                     SKIGKDGIKILGEGNLEKALTVKAAKFTASAQEKIEKAGGKAELV"
     gene            9832..11100
                     /gene="secY"
                     /locus_tag="KRO40_002419"
     CDS             9832..11100
                     /gene="secY"
                     /locus_tag="KRO40_002419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HBH2093236.1"
                     /translation="MLSKLKQAWKIKAVRKKVMYTLMMIVIFRIGTTIPVPGIDTSII
                     QKMVGGNSLLSLYNMFTGGAFSNFSLFALGISPYITASIIIQLLTVGFESLAELQKSG
                     EEGKKKINKYTKYTALALAVVQALGITLGIVRSALISNSVFFITTVVITLVSASMLVM
                     WIGDKITEKGIGNGSSVIIFAGIISRIPTDVIKISQQVKSGEVAPWVIVILAVVILLT
                     VTGVTFIQEATRKIPVQYAKRVVGRKMYGGQSSHIPMKVNQSGVMPIIFASSLLAFPQ
                     TIAMFMGPNAQAFVQKYLSMATEQGFWTYRSIEILLIIFFSYFYTTVSFNTEDISKNM
                     KNNGGFIPGIRPGEPTMDYLNRILTRLTLAGATFLAIIAMVPALTTHYMKVNMSLAGT
                     SLLIVVGVALELKRQLESNLVMRSYQGFLK"
     gene            11117..11767
                     /locus_tag="KRO40_002420"
     CDS             11117..11767
                     /locus_tag="KRO40_002420"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HBH2093237.1"
                     /translation="MRIILLGPPGAGKGTQAAGIVEKYNIPHISTGDIFRKNIKEGTE
                     LGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNGFMLDGFPRNVAQGEHLDIFLKN
                     AGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
                     ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK"
     gene            11768..12514
                     /gene="map"
                     /locus_tag="KRO40_002421"
     CDS             11768..12514
                     /gene="map"
                     /locus_tag="KRO40_002421"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I methionyl aminopeptidase"
                     /protein_id="HBH2093238.1"
                     /translation="MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIA
                     EENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGETILQEGDIVSLDIGAYYKGY
                     HGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
                     VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGW
                     TTVTIDGKKSAHYEHTIAITEHEPLILTKL"
     gene            12536..12805
                     /locus_tag="KRO40_002422"
     CDS             12536..12805
                     /locus_tag="KRO40_002422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KOW domain-containing protein"
                     /protein_id="HBH2093239.1"
                     /translation="MLSDNLSIGQVVKVSLGRDKGNLFFVVKIINNEYVLIADGKKRK
                     LDKPKLKKVKHLKKYNFINDEVRKRVVSGQEITDSFLRAELTKLN"
     gene            12843..13061
                     /gene="infA"
                     /locus_tag="KRO40_002423"
     CDS             12843..13061
                     /gene="infA"
                     /locus_tag="KRO40_002423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001029884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HBH2093240.1"
                     /translation="MAKKDVIELEGTVSEALPNAMFKVKLENGHEILCHISGKLRMNF
                     IRILEGDKVNVELSPYDLTRGRITWRKK"
     gene            13097..13210
                     /gene="rpmJ"
                     /locus_tag="KRO40_002424"
     CDS             13097..13210
                     /gene="rpmJ"
                     /locus_tag="KRO40_002424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003720928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HBH2093241.1"
                     /translation="MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQKQG"
     gene            13363..13734
                     /gene="rpsM"
                     /locus_tag="KRO40_002425"
     CDS             13363..13734
                     /gene="rpsM"
                     /locus_tag="KRO40_002425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HBH2093242.1"
                     /translation="MARIAGVDLPREKRAEIGLTYIYGIGKATANEILAKAEINPDTR
                     IKDLSEDQVNELRKVIDDDFLVEGDLRREIALNIKRLRDIKCYRGIRHAKGLPLRGQR
                     TKTNARTRKGPRKTVSRKKKK"
     gene            13770..14168
                     /gene="rpsK"
                     /locus_tag="KRO40_002426"
     CDS             13770..14168
                     /gene="rpsK"
                     /locus_tag="KRO40_002426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HBH2093243.1"
                     /translation="MAKPKKKVTRIRRRERKNIERGHAHIQSTFNNTIITLTDVHGNA
                     ISWASSGQLGFKGSRKSTPFASQMAAETAAKAAMEHGLKSVEVFVKGPGSGREAAIRA
                     LQATGLEVTMIKDVTPIPHNGCRPPKRRRV"
     gene            14200..14823
                     /gene="rpsD"
                     /locus_tag="KRO40_002427"
     CDS             14200..14823
                     /gene="rpsD"
                     /locus_tag="KRO40_002427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HBH2093244.1"
                     /translation="MARYTGASCRQCRREGMKLFLKGDRCYTDKCAIVKRNYAPGQHG
                     QGRKKVSNYGLQLREKQKVKRIYGVLETQFRNLYERAENMPGKAGENLLSLLERRLDN
                     VVYRMGLASSRKEARQLVTHGHFTLNGNKVDIPSLIVKVGDVIEVKEKSRSSAKFKNL
                     VEVNSRIAPKWLEANVEGMTAKVVGVPTREDIDLEIAEHLIIELYSK"
     gene            14901..15848
                     /locus_tag="KRO40_002428"
     CDS             14901..15848
                     /locus_tag="KRO40_002428"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HBH2093245.1"
                     /translation="MIEIEKPKVDIVELSEDYRYGKFVIEPLERGYGITIGNALRRIL
                     LSSLPGVAVNAIKIDGVLHEFSTIPGVKEDVTEIILTLKELSATIDGEGSRTLKIEAQ
                     GPCSITGADIICPPDVEILSKDLAIATLDDNAKLNMEIFVDKGRGYVSAEENKTENVP
                     IGVLPVDSIYTPVEKVSYHVENTRVGQKTDYDKLVLEVWTNGSINPQEGISLAAKVLV
                     EHLNLFIDLTEHVSSVEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVEE
                     LANKSEDDMMKVRNLGKKSLEEVIQKLEELGLGLKPSEE"
     gene            15869..16210
                     /gene="rplQ"
                     /locus_tag="KRO40_002429"
     CDS             15869..16210
                     /gene="rplQ"
                     /locus_tag="KRO40_002429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003357477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HBH2093246.1"
                     /translation="MAKYRKLGRETAHRNLMLRNLVTCLLRSGRIETTVTRAKETRRM
                     AEKMITLAKRGDLHARRQVLAYVMDETVVNNLFTDLAPKYAERNGGYTRIIKIGPRKG
                     DAAEMAFIELV"
     gene            16330..17163
                     /locus_tag="KRO40_002430"
     CDS             16330..17163
                     /locus_tag="KRO40_002430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBH2093247.1"
                     /translation="MDNIVKVNNISFEYITDEAKLKAIDNLSLDVKKGEFVAIIGHNG
                     SGKSTLSKNLNAILMPTEGNILIDDMDTKEEERLWDIRQTAGMVFQNPDNQIVATIVE
                     EDVAFGPENLGIEPKEIRRIVEESLKSVGMYDLRDRQPHLLSGGQKQRVAIAGIIAMR
                     PKCIIFDEATAMLDPSGRKEVMKTIKRLNKEENITVIHITHFMEEAVEADRVVVMEKG
                     KKILEGTPREVFSKIKMLKEIGLDVPCMTELSSLLIEEGINISSDILTVDEMVMELCQ
                     L"
     gene            17151..18017
                     /locus_tag="KRO40_002431"
     CDS             17151..18017
                     /locus_tag="KRO40_002431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBH2093248.1"
                     /translation="MSIIVKNLTHIYNEGMPFASKALDDVSFEIKDRDFVGLIGHTGS
                     GKSTLIQHLNGLLKPSSGEIFINDFNITDKNLNLTEIRKRVGVVFQYPEYQLFEETID
                     KDIAFGPSNLGLEESEIHNRVKASMEAVGLDYEGFKDKSPFELSGGQKRRVAIAGVIA
                     MNPEVLILDEPTAGLDPGGRDEIFNLIKDLHEKKNMTIILSSHSMDDMAKLAKTLIVM
                     NHGSVEFMGTPREVFKSNASKLKDIGLDIPQVLELALKLREKGFDISEDILTLEEAKQ
                     EILKVVRGRGLC"
     gene            18011..18814
                     /locus_tag="KRO40_002432"
     CDS             18011..18814
                     /locus_tag="KRO40_002432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HBH2093249.1"
                     /translation="MLKDITIGQYYPTSSAIHKLDPRIKLVATIVFMVSIFVVNKFWP
                     YIVVLLCLLAMIKLANIPVKYIVKGVKPLKWIILFTFLINIFFLPGDEIWSFGFLAIT
                     KQGLRQAIFMAIRLIFLVVGTSLLTLTTSPIELTDGIERLLNPFKKIGLPVHELAMMM
                     TIALRFIPTLLDETDKIMKAQMSRGADFESKNLINRAKNLVPLLVPLFVSAFRRADEL
                     AMAMEARCYRGGHNRTKMRESVISRRDYMACVFQVVYLGAIIATRFIAI"
     gene            18846..19577
                     /gene="truA"
                     /locus_tag="KRO40_002433"
     CDS             18846..19577
                     /gene="truA"
                     /locus_tag="KRO40_002433"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBH2093250.1"
                     /translation="MRNIKIKIQYNGKNYCGWQKQPDSLGIQGTIERAIYDITKEETS
                     LIGSGRTDSGVHAIGQIANFKINSGISIESIPMALNAKLPKDISVIEACEVNDDFHSR
                     YSAKGKTYKYLVYNSKFRNPILSEISYQVKYELDFDKMCSEAKSLLGTHDFKGFMSSG
                     SSVKDTVRTIYDIDISKKDDLITFEISGNGFLYNMVRIIVGTLVDMGRGRINEPFLDI
                     IQSKTRSRCGHTAPAQGLFLKKVHY"
     gene            19697..20128
                     /gene="rplM"
                     /locus_tag="KRO40_002434"
     CDS             19697..20128
                     /gene="rplM"
                     /locus_tag="KRO40_002434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HBH2093251.1"
                     /translation="MKSYIAKPADVQRKWYLVDAEGKTLGRLATEIATVLRGKHKPTF
                     TPHVDGGDFVIVVNAEKIVLSGKKLDQKYYRYHTGYVGGLKEISYRDMMDKKPEEVIS
                     HAVSGMLPKNKLRSRMMTRLRVFAGAEHTHAAQNPEVLNFK"
     gene            20157..20549
                     /gene="rpsI"
                     /locus_tag="KRO40_002435"
     CDS             20157..20549
                     /gene="rpsI"
                     /locus_tag="KRO40_002435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003515879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HBH2093252.1"
                     /translation="MANVQYYGTGRRKSSVARVRLVAGEGNILVNGRALENYFNYETL
                     IRDVKQPLVLTGNENKYDVIVKVEGGGFTGQAGAIRHGISRALLKADLDLRPALKKEG
                     FLTRDARMKERKKYGLKAARRAPQFSKR"
BASE COUNT         8271 a         2448 c         4319 g         5678 t
ORIGIN      
        1 ctttactaaa ctaatggatt taatataaaa aaagaggggg gtaactcctc tcttttttgt
       61 tttttgttga caagtagcgc taaagcatat atactaaact agtgccttga gacagattaa
      121 caatcaagtt taaggttatg atgttgtaat agaaaataaa attgaaaaaa acagaaaaaa
      181 aacttgaaaa aatgtaacag atgatataaa atataatagt gtgcttgaga gattaagaaa
      241 ataataatta aatcctagtg aaatacgaac tgatatcgat ttaaaagtta caacacaccc
      301 ggagcagtgt atcggtattg gttgtacgca acttgaaaat taaacacgtg ataaaggagg
      361 gaaaacaaaa tggctaagaa tgaaaaaata agaataagat taaaatcata tgatcacaaa
      421 ttattagatt tttcagcagg taaaatagtt gaaactgcta aaaaggctgg atcacaagtt
      481 tcaggacctg tgcctctacc aacagaaaaa caagttgtaa ctatattaag agctgtacat
      541 aagtacaaag actctagaga acaatttgaa ataagaactc ataaaagact aatcgacata
      601 gctaatccaa cacctaagac agttgactca ttaatgagat tagacttacc agcaggtgta
      661 gatatagaaa taaaattata agaaccccta agatattatc ctatagatga ttatcttaga
      721 atgattactc taaaagatgt aatccgctgt aagaattata ggaggtgcta atatgaaagg
      781 aatattaggc aaaaaagttg gtatgactca aatattcact gataaaggtg tagttatacc
      841 tgtaacagct gttgaagcag ggcctatggt cgttactcaa ataaaaacag ttgataaaga
      901 tggatacaat gctatacaaa taggttttga agatgctaaa gaaaaagctt taaacaaacc
      961 taaaaaagga catttagctg ctgctaatgt tttaaagaaa catttaaaag aatttagagt
     1021 agattctgta gaaggataca cagtaggaca agaaataaaa gctgatgtat ttgaagcagg
     1081 tgcaaaaata gatgttactg gaataagtaa aggtaaggga ttccaaggtc caataaaaag
     1141 acatggacaa agtagaggtc ctgaaactca cggttctaga taccacagaa gaccaggttc
     1201 aatgggagct tgttcttacc caggtagagt atttaaaaac aaaaaattag ctggacatat
     1261 gggaagcgta aaggtaacag ttcaaaactt agaggttgtt aaagtagatg ctgacaagaa
     1321 ccttatatta gttaaaggag ctataccagg agctaaaggt tcagtagtaa ctataaaaga
     1381 agctataaag gtttctaaat aatgactaac ctagagaaag gaggaataac aatgccaaaa
     1441 ttaaatgtac taaatgttag tggacaaaac gttggagaaa tagaattatc agattctata
     1501 tttggcgtag aagttaatgg acatgtttta tacgaagttg taaaaaatca attagcaaat
     1561 aagagacaag gaactcaatc tgctaaaact agagcagaag ttagaggtgg cggaagaaaa
     1621 ccttggaaac aaaaaggaac aggtagagca agacaaggtt ctacaagatc tgtacaatgg
     1681 gtaggtggag gagttgcttt tgcacctaaa ccaagaagct acaaatatac attacctaag
     1741 aaggtaagaa gattagctat gaagagtgct ttatcttcaa aagttcaaaa tagtgaagtt
     1801 atagtattag atgcattaaa catggatgct cctaagacta aagaatttgc tcaaatatta
     1861 aacaatataa atgctgctaa aaaagcttta gtagttatag ctgacaaaaa cgataacgta
     1921 ataaaatcag ctagaaatat agaaggtgtt caaactgcat tagttaatac tatgaatgta
     1981 tatgatatat taaaatacga ttcatttata ataactacag atgctgttaa aaaagtggag
     2041 gaggtgtacg cataatgact aatccacatg atgtaataat aagaccagtt gtaactgagc
     2101 acagtatggc tgaaatgggt gaaaaaaaat acacttttgt tgtggctaaa gatgcgaaca
     2161 aaactgaaat aaaaaaagca gtagaaaaag tattcggagt tagtgttgat aaagtaaata
     2221 ctttaaacta cgatggaaaa gttaaaagaa tgggtagaac tcaaggaaga acatcaagct
     2281 ttaagaaagc agtagttaaa ttaactgctg atagtaaaga aatagaattc ttccaaggaa
     2341 tgtagtatta taacaaacga aggagggaaa acagatggct ataaaaaagt ttagaccaac
     2401 ttctcctgcc ttaagacaaa tgacagtttt agtttctgat gaaataacat gtaatcaacc
     2461 agaaaaatct cttttagtta acttaaagaa aaatgctggt agaaacgtac atggtagaat
     2521 aactgttcgt catagaggtg gaggacaaaa aagaaaatat agaataatag attttaaaag
     2581 agataaagat ggtatacctg ctaaggttgc tactatagaa tatgatccaa acagaactgc
     2641 aaatatcgca ttattaaact atgctgatgg agaaaaaaga tatatattag ctccagttgg
     2701 aattaacgtt ggagatacta tattatcagg attaggtgct gatataaaac caggaaactg
     2761 tttagcatta aaagatatgc cagttggtac tatcattcat aatatagaat taaagccagg
     2821 aaaaggagct caattagtta gatctgctgg agtttctgca caattaatgg ctaaagaagg
     2881 aaaaaatgct ttattaagat taccatcagg tgagatgaga ttagtaagca taaactgtaa
     2941 agctactata ggtcaagttg gaaatataga gcatggtaac gtagttatcg gtaaagcagg
     3001 tagaaaaaga catatgggaa taagacctac tgtaagaggt tctgtaatga accctaatga
     3061 ccatccacac ggtggagggg aaggtagatc tccaataggt agaccatctc ctgttactcc
     3121 atggggtaaa ccagctcttg gatacaaaac tagaaagaaa aataaagctt caaataaact
     3181 aatagtatca agaagaacta agtagtaaat ttatttttgc tcggaaagga ggaatataaa
     3241 tgtcaagatc aactaaaaaa gggccttttg tccatgcaag acttttaaag aagatagaag
     3301 ctatgaatgc tagtggaaat aaagaagtta taaaaacttg gtcaagatct tcaactgtat
     3361 ttccacaaat ggtagaaaac actatagctg ttcatgatgg aagaaaacat gttccagtat
     3421 atataacaga agatatggtt ggacataaat taggtgagtt cgttcctact agaactttca
     3481 aaggacataa ggatgacgaa aaatctaata agagaaaata attaaattat gactaagaaa
     3541 ggaggaataa caatggaagc aaaagctact gctaaatacg tacgtgtatc accaagaaaa
     3601 gcaggccaaa tatgtgacct tgttagagga aagaatgttg atgaagcatt agcaatatta
     3661 aagtttactc caagaggagc agcttcaata atagctaagg ttgtaaaatc agctaaagct
     3721 aacgcagaaa acaatcacga aatggatact gaaaaattat atatagcatc aatagttgct
     3781 aatcaaggac caacaatgaa gagattcatg cctagagcta tgggtcgtgc aactacaata
     3841 agaaaaagaa cttctcatat agaggttgtt gttaaagaaa aaaaataatt aatagatagg
     3901 agggaaagta atgggtcaaa aggttaatcc acacggctta agggtcggtg ttataaaaga
     3961 ttgggactca agatggttcg ctactgataa aaaagagttc ggaaacttat tattagaaga
     4021 ccataatata cgtaaattct taaagaaaag attatactca gctggagttg ctaagataga
     4081 aatagaaaga tcagctaaca aaataaaaat ggacttacac gttgctaagc ctggtgtagt
     4141 tataggaaga gctggtgcag gaatcgaagc attaaaagct gaattagaaa aaatgacaaa
     4201 gaaaactata atagttaata tagtagaagt aagaagtaca gataaaaatg ctcaattagt
     4261 agctgaaaat atagctttag ctatagagag aagggttgct ttcagaagag caatgaaaca
     4321 agctatacaa agagcaatga aatctggtgc taaagggata aaagtttctg cttcaggaag
     4381 attaggtgga gctgaaatgg ctagaactga aggttatagt gaaggaaatg tgccactaca
     4441 aactttaaga gcagatatag attatggttt cgctgaagct gatacaactt atggaaaaat
     4501 cggtataaaa gtttggatat gtaatggtga agttttacca actagagacg gtgtaaatcc
     4561 aagagaagaa agcagaaaga gcgatagaag agacaacaag agagataata gaagaaacga
     4621 tagaagagga aatgacagaa gaggaaatga taacagagga aactacagag gacaaagacc
     4681 tcaaggtgga tcaagacctc aaagaactga aaacaaagga aattaataat agttaggttc
     4741 aaggaaggag gaaaaatact catgttaatg ccaaaaagag taaagcgtcg tagagttcat
     4801 agaggaagca tggctgggca agctcataag ggtaataaag ttacttatgg tgagtttgga
     4861 ttagtagcat tagaagcttc ttggataact tctaatcaaa tagaagctgc cagaattgcg
     4921 atgactagat atataaaaag agggggaaag gtttggataa aaatattccc tcataaacca
     4981 gtaacaagaa aaccagcaga gactcgtatg ggtgcaggga aaggttctcc agaatattgg
     5041 gtagctgtag ttaagccagg aagagttatg tttgaattag caggtgtttc tgaagataaa
     5101 gcaagagaag ctatgagact tgctgcacat aaattaccaa tcaaatgtaa atttgttaaa
     5161 aaagaagatt tagaagtaaa gggtggtgaa taggatgaaa gctaaagaat taagagattt
     5221 aacaagcgaa gagctaatga acaaattaaa cgacttcaaa agtgaattat ttagcttaag
     5281 attccaatta gctactggtc aattagaaaa tacagctaga ataaagtttg ttaagaagga
     5341 tatagcaaaa gttaaaactg ttcttgctga aagaaagtta tacgaaacta gagcttaatt
     5401 tggaaaggag gctttttaaa catggaaaga ggaagaagaa aagttagaat aggccgtgtt
     5461 gttagtgata agatggataa aacaatagta gtagctgttg aagaattcgt acgtcatcca
     5521 ctatataata aacgtgttaa gagaactaag aaattcaagg ctcatgatga aaagaatata
     5581 tgtaacatcg gagatagagt taaaataatg gaaactagac cattatctaa agataagaga
     5641 ttcagactag ttgaagttgt tgagaaagtt aagtagtttt tgaagaagga gggattacga
     5701 tatgatacaa caagaatcac gtctaagagt tgctgataac tcaggagcta aagaactttt
     5761 atgtatacgt gttctaggcg gaagtaaaag aagatatggt aacataggcg acgttatagt
     5821 tgctactgtt aaaagtgcaa cacctggtgg agttgtaaaa aaaggtaagg ttgttaaagc
     5881 tgttatagta agaagcaaac aaggcgtaag acgtaatgac ggaagctata tatcttttga
     5941 tgaaaatgct gctgttataa taaaggacga taaaactcca gtaggaactc gtatattcgg
     6001 gcctgttgct agagagttaa gagacaatga attcatgaaa atagtttctc ttgctccaga
     6061 agtactataa ttaaggaggt gcaataggac atgatgcgtg ttaaaaaagg tgacactgtt
     6121 gtagttatag caggtaaaga taaaggtaaa aaaggttcag ttttaaaggt atatcctaaa
     6181 actagcaaag tgttagttga aggtgtaaat gtaataacta aacatcaaaa accaagtgct
     6241 atgaaccaac aaggtggaat aataaataaa gaagccccaa tacacatatc taatgtaatg
     6301 ccatttgatc ctgaaacagg aaaaggcgtt agagtaagat atgaagtaaa agatgggaac
     6361 aaagtaagag tatcagcaaa gagcggaaaa gaattataat aaatattgct tgaaaggagg
     6421 gaccttaaat ggcttctaga ttacaagaaa aatacatgaa agaagttgct cctgctttaa
     6481 tggagaaatt tggatacaaa aacgtaatgg agatacctaa gttaaataaa atagttatta
     6541 acatgggtat aggtgacgct agagaaaatc caaaaggatt agaaaaaggc gttgaagaat
     6601 tagaaatgat atcaggacaa aagcctgtta taactaaagc tagaaaatct gttgctaact
     6661 tcaaattaag agaaggaatg ccaataggaa caaaagttac attaagagct gacaaaatgt
     6721 tctactttat ggacaaatta gtttcagttt ctttaccaag agttagagac tttagaggag
     6781 ttaaccctaa tgcttttgat ggtagaggaa attatgcttt aggagttaaa gaacaattaa
     6841 tattccctga aatagaatat gataaaatag ataaagtaag aggaatggat ataatatttg
     6901 ttactacagc aaaaactgac gaagaagctc gtgaattatt aaaattatta ggaatgccat
     6961 tttctaagta agcaaaggag ggattcccgt ggctagaaaa gcgatggttg ttaagcaaca
     7021 aagaaagcaa aagtacgcta ctagagaata cactagatgt actatatgcg gaagaccgca
     7081 ttcagttttg aaaaaatttg gtatatgccg tatatgcttt agagaattag cttataaagg
     7141 tcaaatacct ggtgttagaa aagcaagctg gtagaagctt gattagaatg gaaggagggc
     7201 aacaaaatga caatgacaga tccaattgca gatatgctta ctcgtataag aaatgctaat
     7261 gttgttaagc atgaaactgt agatgttcca gcttctaata tgaagaaaga attagctaga
     7321 atcttattag aagaaggttt cataagaggt tatgatgtta tagaagatgg aaaacaaggt
     7381 atcataagaa tacaattaaa gtacggacaa gaaggcgaaa gagttataac aggtcttaag
     7441 aaaatatcta agcctggaat gagagtttac gctgctaacc atgagatacc aaaagtatta
     7501 aacggattag gaatatcagt tatatctact tcaaaaggaa tattaactga caagcaagct
     7561 agaaaagaaa atgttggtgg agaagtaatc tgctacgttt ggtaattaat atgaacaatg
     7621 taaggaggtg cgaccatgtc aagaataggt gttaagccaa taataatacc agcaggtgtt
     7681 gaagttacta tagctgaagg aaatttagtt acagtaaaag gtccaaaagg aactttaact
     7741 aaacaattaa gtgctgagtt aaacataaaa aaagaagaaa atacaataat ggttgaaaga
     7801 ccaactgata ataaaaaaca tagatcttta cacggactaa ctagaacttt attagataat
     7861 atggttgtag gtgtaaatac tggtttcgaa aagaaattag aattaaaagg tgttggatat
     7921 agagctcaaa aacaaggaaa gaaattagtt atgaacttag gtttctctca tccagttgag
     7981 atggaagatc cagaaggaat aactgttgaa gctccaaacc aaacagagtt aatagtaaaa
     8041 ggtatagaca agcaattagt agggaattat gctgctaaga taagagcttg gagaaagcca
     8101 gagccataca aaggtaaagg tataaaatac gttgatgaag taatcagacg taaagaagga
     8161 aaaactggta aaaaataata ccaaaactta aacgctagaa aggagtgagc taggtgttaa
     8221 aaaaggctga taaaaatgct aatagacttc aaagacataa gagagttcgt agaaaaataa
     8281 gcggtacttc tcaaagacca agattatgtg tatttagaag tgctaacaat atatatgctc
     8341 aaataataga tgacacaaaa agagtaactc tagttgctgc atcttcttta gaagcagaag
     8401 ttaagagtgc tgtcaatcat acaggaaaca aggaagcagc taagaaagtt ggagaattag
     8461 ttgctaaaaa agctgttgaa aaaggaatca ctgaagttgt atttgacaga ggtggatact
     8521 tatatcatgg aagaattcaa gaattagctg aaggtgctag agaagctggt cttaagttct
     8581 aatacgaagg agggaaaaat acatgctacg tcgtaagccg atagatgcag gacaacttga
     8641 cttacaagaa aaagttgttg aagtaagacg tgttactaag gttgtaaaag gtggtagaaa
     8701 tttcagattt gcagcattag tagttgttgg agatgaaaac ggacacgttg gtataggtgc
     8761 tgggaaagca atggaagtac cagacgctat aaaaaaagca gttgaagatg ctaagaaaaa
     8821 tctaatagta gtgccaatag ttgggactac aattcctcac gaagtacgcg gacactttgg
     8881 tgctggaaat atattaataa tgcctgctgt agaaggtaca ggagtaatag ctgggggacc
     8941 tgctagagcc gtacttgagc tagctggact aaaagacgtt agagctaaat ctttagggtc
     9001 taacaatcca agaaatatgg taaatgctac aatagaagga cttaattctc taaaaacagt
     9061 tgaagatata gctaaactta gaggtaaaaa agttgaagaa cttctagggt aaggaggtag
     9121 tgtaaaatgg ctaaattaca aataaagtta gttagaagtg ttataggaac tactcctaac
     9181 caaaaaaaga atgttgaagc gttaggatta agaaaaagag aacaagttgt tgtaaaagaa
     9241 gacaatgctc aaacaagagg tatgataaat aaagtaagtc acttattaga agtaactgaa
     9301 atagctgaat aatttttata aagtagtgca aggaggtgca atccatgaag ttacatgagt
     9361 taaaacctgc tgaaggtgca gtaagagcta agagaagatt aggtagaggt actgcaactg
     9421 gacaaggtaa aactgcagga cgtggacaaa aaggtcaatg gtctcgttct ggtggtggag
     9481 taagagtagg atttgaaggt ggacaaatgc cactagctag aagacttcct aagagaggtt
     9541 tcaataacat atttaagaaa gtttacacag aagttaatgt tgaagtttta aacagatttg
     9601 aaaatggaac agaaataact gcagaattat taaaatctac taaaactata agcaaaatag
     9661 gtaaagacgg aattaaaatc ttaggtgaag gtaatttaga gaaagcttta actgttaaag
     9721 ctgctaaatt tacagcttca gctcaagaaa aaatagaaaa agctggtgga aaagcagagt
     9781 tagtataata acctgctaat ctcctagcca gtacaggcgg ggtgaattag cgtgctgtca
     9841 aaattaaaac aagcttggaa gattaaagca gtaagaaaaa aagtaatgta tacacttatg
     9901 atgatcgtga tattcagaat aggtactact ataccagttc caggcataga cactagtatt
     9961 atacaaaaga tggtaggcgg caatagtcta ctttctctgt ataatatgtt tactggtgga
    10021 gcatttagta acttttcact atttgcttta ggtataagtc catatatcac tgcatcaatc
    10081 ataatacaac ttctaacagt aggttttgaa agtttagcag aacttcaaaa atctggtgaa
    10141 gaaggaaaga aaaaaatcaa taagtacact aaatatacag cactagctct agcagttgta
    10201 caagctttgg gaattacatt aggaattgta agaagtgctt taatatcaaa tagtgtgttt
    10261 tttatcacaa ctgttgtaat aacattagtt tcagcaagta tgttagtaat gtggattggg
    10321 gacaaaatta ctgaaaaagg aatcggtaat ggtagttcag taataatatt tgcaggtata
    10381 atatcaagaa tacctacaga tgttattaaa atatcgcaac aagttaaatc tggcgaagtt
    10441 gcaccttggg ttatagtgat tctagctgta gttatattac ttacagtaac aggagttaca
    10501 tttatacaag aagcaactag aaagatacct gtacaatatg ctaaaagagt tgttggaaga
    10561 aaaatgtatg gaggacaaag ttctcatata ccaatgaaag ttaaccagtc aggagttatg
    10621 cctataattt ttgctagttc acttttagct ttccctcaaa caatagctat gtttatgggt
    10681 ccaaatgctc aggcttttgt tcaaaaatac ttaagtatgg caacagaaca aggattttgg
    10741 acatatagat caattgagat tctacttata attttcttct catattttta tacaactgta
    10801 tcatttaata cagaagacat atctaaaaat atgaaaaata atggtggatt tataccaggt
    10861 ataagaccag gtgagcctac tatggattat ttaaatagaa ttttaactag attaacttta
    10921 gctggagcta ctttcttagc aataattgct atggtgccag ctcttacaac acattatatg
    10981 aaagtaaata tgagtctagc tgggacttca ttgctaatcg ttgttggagt tgctttggag
    11041 cttaagagac agttagagtc aaacttagtt atgagaagct atcaaggttt cttaaaataa
    11101 aatggagatg gataatatga gaataatatt acttggacct ccaggtgctg gtaaaggtac
    11161 tcaggcggca ggaatagtag aaaaatacaa tatacctcat atatcaacag gagatatatt
    11221 cagaaagaat ataaaagagg gaacagaact tggaaaaaaa gctaaagaat acatggacca
    11281 aggtttatta gtaccagatg agttaactgt aggtttagtt actgatagaa tatctcaaga
    11341 agattgtaaa aatggattta tgttagatgg atttccaaga aatgtagcac aaggagaaca
    11401 tttagatatc ttcttaaaaa atgctggtat atcactagat aaagttgtca atattgaagt
    11461 tgataagagt atattagtgt ctagagcagt tggtagaaga atatgtaagt cttgtggagc
    11521 tacttaccat gttgagttta atcctcctaa agtagaaggt gtatgtgatg tatgccaagg
    11581 agaattatat caaagagctg atgataatga agaaactgta tctaagagaa tacaagttta
    11641 tctagatgaa actaagcctt tagtagatta ttatagcaaa caaggtataa tagcagatat
    11701 aaaaggtgat caagcaatag ataaagtatt tgaagatatt gtcgcagcct taggaagtgg
    11761 aaaataaatg attatcttga aatcaaaaaa agaaatagaa cttttaagag aagcaggtaa
    11821 aatagttgct gacactcatg aagttttaag aaaagctatt tctccgggaa tatctacttt
    11881 agaattagat aaaatagctg aagagaatat aagaaaatac aatgcagaac cttcttttaa
    11941 aggatatgga ggttttccag gaagtatatg tgcttctatc aatagagagg tagtacatgg
    12001 tattccagga gaaactatat tacaagaagg tgacattgta agtttggata taggagccta
    12061 ttataaagga tatcatggtg attctgcgaa aactcacgga gtaggcatga tatctgaaga
    12121 agataggaaa ttgatagaag taactagaga aagcttctat gaaggaataa aatttgctaa
    12181 attaggatat agactttcag atatctcaca cgcagtacaa acacacgttg agaaacatgg
    12241 tttctcggta gttagagatt tagtgggtca tggagttgga gcaaatcttc atgaagaccc
    12301 acaagtacct aattatggac tcccaggaaa aggaccaaga cttagagaag gaatggttat
    12361 tgctatagag ccaatggtta atgcaggtcg ttatcatgta aagactctat cagatgggtg
    12421 gacgactgtt acaatagatg gaaaaaaatc agctcattat gagcatacga tagcaattac
    12481 tgaacatgaa cctttgatat tgacaaagtt gtaatttaaa aagtaggtga aaaaagtgct
    12541 atcagataat ttaagtatag gtcaagttgt taaagtttca ttaggacgag ataaaggaaa
    12601 tttattcttt gtagtcaaaa taattaataa tgaatatgta ttaatagctg atggaaaaaa
    12661 gagaaaactt gacaaaccta agttaaagaa agtgaagcac ttaaaaaaat ataattttat
    12721 taatgatgaa gttagaaaaa gagtagtatc tggacaagag attacagatt cttttttaag
    12781 agctgaactt actaagttaa attagataat ttaacttatt gaaatggagg gctggttagt
    12841 taatggccaa aaaagatgtt atagaattag aaggtacagt ttcagaagct ttacctaatg
    12901 ctatgttcaa agttaaacta gaaaatggac atgagatatt atgccacatt tctggaaagc
    12961 taagaatgaa cttcataaga attcttgaag gtgacaaggt gaatgttgaa ctttctccat
    13021 atgaccttac aagaggaaga attacttggc gtaagaagta gactatatta atatttagtc
    13081 taaggaggga ttaataatga aggttagacc atcagtaaaa ccaatatgtg aaaaatgtaa
    13141 agtaataaaa agaaaaggaa aagtaatggt tatctgtgaa aatccaaagc ataagcaaaa
    13201 gcaaggataa gaaattatta ctagcatttt gttaaatttt atagtataat actatattgt
    13261 gatgttaaca aaagaacgtt aaaatcgttg aacaatctgg cgtaggattg gcatatgatg
    13321 tgaagtttta aacactaaaa actatgtgta ggaggtgcga tcatggcaag aatagctggg
    13381 gtagatttac ctagagaaaa aagagcggag ataggcttaa cttatatata tggtataggt
    13441 aaagcaactg ctaacgaaat attagctaag gctgagataa atccagatac tagaataaaa
    13501 gatttatcag aagatcaagt taatgagtta agaaaagtta tagatgacga tttcttagtt
    13561 gaaggtgact taagaagaga aattgcttta aacataaaga gattaagaga tataaaatgt
    13621 tatagaggaa taagacacgc taaaggtctt ccattaagag gacaaagaac taagactaat
    13681 gctagaacta gaaaaggtcc tagaaaaaca gtatctcgta aaaagaaaaa ataaataaat
    13741 aataactaga tgaaggaggg aaaaggaaaa tggctaaacc aaaaaagaaa gttacacgta
    13801 ttagaagaag agaacgtaaa aatatagaac gtggtcatgc tcatatacaa tcaactttca
    13861 ataatacaat aataacttta actgacgttc acggaaatgc tatatcttgg gcaagttctg
    13921 gacaattagg attcaaagga tcaagaaaat caactccatt tgcatctcaa atggctgctg
    13981 aaacagctgc aaaagctgcg atggaacacg gactaaaaag tgttgaggta ttcgtaaagg
    14041 ggccaggttc aggaagagaa gctgcaataa gagctttaca agcaactgga ctagaagtaa
    14101 ctatgataaa agacgttact ccaatcccac ataacggatg cagaccacca aagagaagaa
    14161 gagtgtaatt aataagagta caataggagg tgtagataaa tggcaagata tacaggtgca
    14221 tcatgtagac aatgccgtag agagggaatg aaattattcc ttaaaggtga tagatgttat
    14281 acagacaaat gtgctatagt aaaaagaaac tatgctccag gtcaacatgg ccaaggaaga
    14341 aagaaagttt ctaactatgg attacaatta agagaaaaac aaaaagttaa aagaatatat
    14401 ggagttttag agactcaatt tagaaattta tatgaacgtg ctgaaaatat gcctggtaaa
    14461 gcaggtgaga acttattaag tttattagag agaagattag ataatgtagt ttacagaatg
    14521 ggactagcat cttctagaaa agaagctaga caattagtga ctcatggtca tttcacttta
    14581 aatggaaata aagtagacat accttcatta atagttaaag ttggagatgt tatagaagtt
    14641 aaagagaaat caagatcttc tgcaaaattc aaaaatttag tagaagttaa ctcaagaata
    14701 gctcctaagt ggttagaagc taatgtagaa ggaatgacag caaaagtagt tggtgttcca
    14761 acaagagaag atatagatct tgagatagca gagcacttaa tcatagaact ttactctaaa
    14821 taataagcac acttttaaaa attattttaa aattttgttt accctcagtg gattactgaa
    14881 ttttaaggag ggttttgtcc atgatagaaa tagaaaagcc aaaagtagat atagttgagc
    14941 ttagtgaaga ctatagatat ggtaagtttg ttatagaacc tctagaaaga ggatatggaa
    15001 taactatagg taacgcatta agaagaatat tattatcatc attaccaggt gtagcagtga
    15061 atgctataaa aatagatgga gttcttcatg aattttcaac aatacctggt gttaaagaag
    15121 atgttactga gataatatta actttaaaag agctttcagc aactatagat ggtgaaggaa
    15181 gtagaacact taaaatagaa gctcaaggac catgctctat cacaggtgca gatataatct
    15241 gtcctccaga tgttgaaata ttaagtaaag atttagcaat agctacatta gatgataatg
    15301 ctaaacttaa tatggagata tttgtagata aaggtagagg ttatgtttct gctgaagaaa
    15361 ataaaacaga gaatgttcca ataggtgttt tacctgtgga ttcaatatat actcctgttg
    15421 agaaggttag ttatcatgtg gaaaacacaa gagttggtca aaaaacagat tatgataaat
    15481 tagtactaga agtttggact aatggtagta taaatcctca agagggaata tcattagctg
    15541 caaaggtatt agttgagcat ttaaacttat ttatagactt aactgaacat gtaagtagtg
    15601 ttgaaatcat ggtagaaaaa gaagaagatc aaaaagaaaa agttcttgaa atgactatag
    15661 aagaattaga tttatcagtt agatcatata actgtttaaa gagagcggga attaatacag
    15721 ttgaagaatt agctaataaa tctgaggatg atatgatgaa ggttagaaac ctaggtaaga
    15781 agtcattaga agaggtaata caaaaactag aagaacttgg attgggatta aaaccaagtg
    15841 aagaatagcg agcaaaggag ggataagaat ggctaagtac cgtaaattag gacgtgaaac
    15901 agctcacaga aaccttatgt taagaaactt agtaacttgc ttactaagaa gtggaagaat
    15961 agaaactaca gtgactagag cgaaagaaac tcgtagaatg gctgaaaaga tgataactct
    16021 tgctaagaga ggagatcttc atgctagaag acaagtttta gcttatgtta tggatgaaac
    16081 agtagttaat aacttattca cagatttagc tccaaaatat gctgagagaa atggtggata
    16141 cactagaata ataaaaatag ggccaagaaa aggcgatgct gctgaaatgg cttttataga
    16201 attagtatag taaggaaagg attaggcttg atggcttaat ctttttttta tttttttgac
    16261 taaggtatga tataataatg tgtaaaatga tttttataag ttattgctta ctaaaaggag
    16321 tatgagttaa tggataatat agtaaaggta aataatattt cgtttgagta tattacagat
    16381 gaagcaaaac ttaaagcaat agataattta agcctagatg ttaaaaaagg agaatttgtt
    16441 gcgataatag gacataatgg ttctggtaag tctactttat ctaaaaactt aaatgctatt
    16501 cttatgccca ctgaaggaaa tattcttatt gatgatatgg atactaaaga agaagaaaga
    16561 ttatgggata taagacaaac tgcaggcatg gtatttcaaa atccagataa tcaaatagtt
    16621 gctactatag tagaagaaga cgttgcattt ggacctgaga acttaggtat agaaccaaaa
    16681 gaaataagac gaattgtaga ggagtcttta aaaagtgtag gtatgtatga tttaagagat
    16741 agacagcctc atttgttatc aggaggtcaa aagcaaagag ttgcaatagc aggaattatt
    16801 gctatgaggc ctaaatgtat aatctttgat gaagcaacag caatgttaga tccatctgga
    16861 agaaaagaag ttatgaaaac aataaaaaga cttaataagg aagaaaatat aactgttata
    16921 catataacgc actttatgga agaagcagta gaagctgata gagttgtagt tatggaaaaa
    16981 ggaaagaaaa tcttagaggg aactcctaga gaagtattca gtaaaataaa gatgttaaag
    17041 gaaatcggtt tagatgtacc ttgtatgaca gagttatcta gtttattaat agaagaaggt
    17101 ataaatatta gtagtgatat attaactgtg gatgagatgg tgatggaatt atgtcaatta
    17161 tagtaaagaa tttaacacat atatataatg aagggatgcc ttttgcaagt aaggcacttg
    17221 atgatgtttc ttttgagatt aaagatagag attttgttgg tcttataggt catacaggct
    17281 caggaaaatc tacattaata caacatttaa atggattact aaagccttcc tcaggagaaa
    17341 tatttataaa tgattttaat ataacagata aaaacttgaa tttaactgag attagaaaaa
    17401 gagtaggggt tgtatttcaa tatccagaat accaattgtt tgaagaaacg attgataaag
    17461 acatagcttt tggaccctct aatttaggct tagaggagtc tgagatacat aacagggtaa
    17521 aagcatcaat ggaagctgta ggacttgatt atgagggatt taaagacaaa tctccttttg
    17581 aattatctgg gggacaaaag cgtagagtag caattgctgg agttatagcc atgaacccag
    17641 aagttctcat attggatgaa ccaactgctg gtcttgaccc tggtggaaga gatgaaattt
    17701 ttaacttaat aaaagactta catgaaaaaa agaatatgac tataatacta tcatcacata
    17761 gtatggatga tatggcaaag ttagcaaaaa ctttaattgt tatgaatcat ggtagcgtag
    17821 aatttatggg aactcctaga gaagtattta aatcaaatgc tagtaaatta aaagatatag
    17881 gattagatat tccacaagtt ttagagcttg cattgaaatt gagagaaaaa ggctttgaca
    17941 tcagtgagga tatattgact ttagaagaag caaaacagga aatattaaaa gttgtgagag
    18001 gacgaggatt atgttaaaag atataactat agggcaatac tacccaacaa gttctgctat
    18061 tcataaatta gatccaagga taaagcttgt agcgacaatt gtatttatgg tatctatatt
    18121 tgtagtaaat aaattttggc cttatatagt agttttatta tgtttattag ctatgataaa
    18181 attggctaat ataccagtca aatatattgt taagggtgtt aaacctctta aatggattat
    18241 tttgtttaca tttcttataa atattttttt cttaccaggt gatgaaatat ggtcatttgg
    18301 atttttagct attacaaaac agggtctaag acaagcaatt tttatggcaa taagattaat
    18361 atttttagta gttggtacat cattgcttac tttaacaact tcaccaatag aattaactga
    18421 tggaatagag agattgttga atccatttaa gaaaattggt ttgccagttc atgaacttgc
    18481 aatgatgatg acaattgctt tacgttttat tcctacattg ttagatgaga cagacaaaat
    18541 aatgaaggct cagatgtcta gaggtgcaga ttttgaaagt aagaatctta taaatagagc
    18601 aaagaattta gtaccacttt tggtaccttt atttgtaagt gcatttagaa gagctgatga
    18661 attggctatg gccatggagg ccagatgtta cagaggtgga cataatagga ctaagatgag
    18721 agagtctgtt atatcaagaa gggattatat ggcatgtgta tttcaggttg tttatctggg
    18781 agcaattata gctactagat ttatagcaat ttaattaata agttatagat ataatgaggt
    18841 aaagtatgag aaatataaaa attaaaatcc aatacaatgg taagaattat tgtggatggc
    18901 aaaagcaacc tgattcttta gggatacaag gtacaattga aagggctata tatgatataa
    18961 caaaagaaga aaccagtctt atagggtctg gtagaactga ttcaggagtt catgctattg
    19021 gtcagattgc aaattttaaa attaattcag gtataagtat agaaagtata ccaatggcac
    19081 taaatgccaa gttgccaaaa gacatatcag ttatagaagc atgtgaagta aatgatgatt
    19141 ttcactccag atacagtgca aaaggtaaaa catataaata tttagtatat aatagcaagt
    19201 ttagaaatcc aatacttagt gagatatcat atcaagtaaa atatgaactt gattttgata
    19261 aaatgtgttc agaagcaaaa agtttattag gaacacatga ttttaaaggt tttatgagtt
    19321 ctggttcatc tgtaaaagat acagttagaa cgatatatga tattgatata agtaaaaaag
    19381 atgacttgat tacttttgag attagtggta atggtttttt atataacatg gtgaggatta
    19441 ttgttggaac acttgttgat atgggtcgtg gcagaattaa cgaaccattt ttagatataa
    19501 tacaatcaaa aactaggtca agatgtggac atacagctcc agcacaagga ttatttctca
    19561 aaaaagttca ttattaactt gacacaccag gctacatgta ttaaaatata tgagaatgtg
    19621 ttaataagtc cacttgcccc ggacttgaca taaacggtaa aaaaatttta tgaaaagtag
    19681 ttaaggaggg acagttatga aaagttatat agctaagcca gctgatgtac aaagaaaatg
    19741 gtacttagtt gatgctgaag gaaaaacatt aggtcgttta gcaacagaaa ttgcgacagt
    19801 attgagaggt aaacataaac caacatttac tcctcacgtt gatggtggag attttgttat
    19861 tgtagtaaat gcagaaaaaa tagttttaag tggtaagaaa ttagatcaaa aatattacag
    19921 ataccatact ggttatgtag gtggattaaa agaaatatct tacagagata tgatggataa
    19981 gaaaccagaa gaagttatat cacatgctgt aagcggtatg ttacctaaaa ataaattaag
    20041 aagcagaatg atgactagat taagagtatt tgcaggtgct gagcacactc atgcagctca
    20101 aaatccagaa gttttaaact ttaaataaga ttaataggtg aaaggaggag tttataatgg
    20161 ctaacgttca atattatgga actggaagaa gaaaaagttc tgttgctaga gtaagactag
    20221 ttgcaggtga aggaaatata ttagtaaatg gaagagcatt agaaaattat tttaattatg
    20281 agacattaat aagagatgtt aaacaaccat tagttttaac tggtaatgaa aataaatatg
    20341 atgttatagt aaaagttgaa ggtggaggat tcactggaca agctggagct ataagacatg
    20401 gaatatctag agctttatta aaagctgatt tagatttaag acctgcttta aagaaagaag
    20461 gtttcttaac tagagatgca agaatgaagg aaagaaagaa atacggatta aaagcagcaa
    20521 gaagagctcc acaattctca aaaagataat tacttatttt tttggaaaag caaaatcctt
    20581 tatttactgt tattcagaaa gtattggtat tttaaaaatg ttgggttaag ttaattattg
    20641 atatataata aaataataag atatcttatt aggatgtttt tcattaagaa gaacatcctt
    20701 tttattttga ctattt
//
LOCUS       DAEQCW010000069        20566 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.069, whole genome shotgun sequence.
ACCESSION   DAEQCW010000069 DAEQCW010000000
VERSION     DAEQCW010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20566)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20566)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20566
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.069"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            64..987
                     /locus_tag="KRO40_002436"
     CDS             64..987
                     /locus_tag="KRO40_002436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2093253.1"
                     /translation="MEIRVLRYFLAIAREESISGAATFLHITQPTLSRQIMELEEELG
                     VKLLVRGNRKITLTNEGRLLHKRAEEIISLVDKVELEFDNPNEIISGDIYIGSGETEA
                     MRLIARTAHHFHQKYPNVRYHLFSGNADDVTEKLDKGLLDFGILIEPANIQKYDYAQI
                     PATDVWGLLMRKDSALASQSTINPKDLCNIPLIISRQTLVDKAISKWLQDSNEKLNII
                     ATYNLVYNASLLVEEGLGYALCLDRLVNTTENSNLCFRPLSPPLEAKLNIIWKKHQIF
                     SKAAEKFLLQIQKDFSSIMLDTSKLDTPKEK"
     gene            complement(1159..2301)
                     /locus_tag="KRO40_002437"
     CDS             complement(1159..2301)
                     /locus_tag="KRO40_002437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBH2093254.1"
                     /translation="MDFKIEKYLLKKTEELAFITIKHGGEFKLKSYEVPKGGLDVPIK
                     NEVLVKGIKEKTAQDKLNSMSIADAMIYIIGIDSKFKNNAEYEKFLNALSKDIDLDLK
                     SYMGYMSRKYFEIGEHTDSLIYIKAFITMYPDDLDAMYNYAIVCQEIAKQYQKDMDDK
                     AMNAFLLEAMAKLEKVIDVDENFALGYYHLGYHYYNQGQYLKTKLTWEEALRLGLDAD
                     LVAEVQENLGKMDFKVQYEEGYTLVFQGKFKEGLEKLLPLEEEHMDWWNLLFMIALGY
                     KGMGEIEQAKMYLEKILIIKPNQVDTIVELGLCEAYKNNLDKAIEYFEQAAKIKEDPE
                     ILCNLGMAYLNNGDIDDATYYIERAYELNPQDEITIACLRELGINK"
     gene            complement(2319..4073)
                     /locus_tag="KRO40_002438"
     CDS             complement(2319..4073)
                     /locus_tag="KRO40_002438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B12-binding domain-containing radical SAM
                     protein"
                     /protein_id="HBH2093255.1"
                     /translation="MKILLTTLNSKFIHTNLAIRYLKEFVRDLIEVNMKEYTINNDLD
                     YILKDIYKNEYDIILFSTYIWNVGDIVKLCDNLKKIRPNTKIALGGPEVSYDSYEAMK
                     KYDFVDYILYGEGELIFRDLVLHLQGKMEINDVNGLVYRQGNEIIVNKPMELLQNLDE
                     IPSPYENLNPKEYENRIVYYESSRGCPFNCQYCLSSTIPGLRYFSLDRIKSDLKALID
                     ARVSQIKFIDRTFNANRKVAMEIMDFLMKNDNGYTTYHFEVTAYLIDDKMLEFLADCK
                     EGLFQFEIGVQSTNEKTLDAVGRRDDFKKLSHVVQTVASYRNIHQHLDLIAGLPYEDY
                     KSFENSFNDVFNLGIEHLQLGFLKMIKGTGMRKVADEHGFKYKDYAPYEFLYNNYISY
                     EETLKLKDIEDILERYYNSKNFVLSMRYIIGRFYKKSPFKFFEVFAKYFDENGYFDLA
                     QGKNQLYKILMDFYNEKINIDNDVFNDILKYDYISLGKTSNIPQFFNKLDVDDFKNRC
                     HVFLQDNDNLSTYLPSFVDKPAKHIIKYVHFEPFRFNVVDLKNDINTEIREVENVVLF
                     EYDDKKIFEKSKTHKVEI"
     gene            4209..4415
                     /locus_tag="KRO40_002439"
     CDS             4209..4415
                     /locus_tag="KRO40_002439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093256.1"
                     /translation="MELIEKVSINSLSKRDLLLIIKSLEYTNENTQISDFIDLRNNIV
                     KELCFLTDTKEKDFLDYLEKNSTL"
     gene            complement(4420..5343)
                     /locus_tag="KRO40_002440"
     CDS             complement(4420..5343)
                     /locus_tag="KRO40_002440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093257.1"
                     /translation="MNDELLKKVYTSSFSSASRALKDLTIINTKSLIDDKTQRCVYID
                     ENRLRDELIYYRFYGEKIGNINFLNILLPLILSNTNIQKSEDEVIKLIKKYVIYFKKE
                     ELLFDYLLGSVVYNSIMHNLINNSKIEYVELLQSIKDKIIGFSIELDKSDVVKFQMAR
                     IKAIQLIDKYIDLKSEDYDEESILLNVLNVLYDVYMEDRIVENEGINSIKKSILSILG
                     EDSKLNEDNIDFIFSMSEYVVKLRKYKIGVKAYNKSIDPRSLIRLEEGNTIIDPIFNQ
                     ITVMSKTFNDNILSIKINSKSGIYILKFKKV"
     gene            complement(5598..7298)
                     /locus_tag="KRO40_002441"
     CDS             complement(5598..7298)
                     /locus_tag="KRO40_002441"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HBH2093258.1"
                     /translation="MQDFKVAISNCLKEKIEDLSKEEIEALIEVPPNKDMGDYAFPCF
                     KLAKVFRKAPNMIASELAESIEPSGEITKVIQLGGYVNFFVNKSQLAETVIKKVLDEK
                     ENYGHSDFGKDKTVIVEYSSPNIAKPFHIGHIRTTVIGNALYKIYDSQGYKTIRINHL
                     GDYGTQFGKLIVAFKKWGEKEVVESNPIPELLKLYVRFHDEAEQHPEMEDEARAWFNK
                     LENGDEEAQELWQWFRNESLKEFNRVYKLLDIEFDSLAGESFYSDKMNRVIELLEEKN
                     LLKESKGARIVDLEEYKMPPALITKNDGSTLYMTRDLAAAIYRKETYDFDKCIYVVGS
                     QQNLHFQQWFKVIELMGYDWAKDLIHVGFGMVALEEGTMSTRKGRVVFLEDALNQAID
                     KTKEIILAKNPNAKNVDEISKQVGVGAVVFQELSNSRIKDYTFSWERTLSFDGETGPY
                     VQYTHARCCAVLRKAEVEVTSDIDYSLLADEDSAEVLRVIESFNKNILLALKKNEPHI
                     VTRFMLDLAQAFNKFYHDNPILVENLEIRKARLALVLATKQTLENSLKLLGMHAPERM
                     "
     gene            complement(7761..8174)
                     /locus_tag="KRO40_002442"
     CDS             complement(7761..8174)
                     /locus_tag="KRO40_002442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBH2093259.1"
                     /translation="MILVSACLIGINCKYSGDNNDNEKVKEYLKGKEFTLVCPEQLGG
                     LSTPRPPAEIVDGKVITKDNKDVTENFVRGANETLKIANLYVCSEAILKEGSPSCGCN
                     LIYDGSFSGKKIPGKGITARLLEEEGIKVKSEKDL"
     gene            complement(8240..10618)
                     /locus_tag="KRO40_002443"
     CDS             complement(8240..10618)
                     /locus_tag="KRO40_002443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBH2093260.1"
                     /translation="MNEKSLRVLEYNKIIDLLKKKASSSLGLKYIENLVPNTDFVEVK
                     SMLEETSEAQSIIIKRGSVGLEGIHDIEDKVKRAYIGASLDPGSLIMIADTLRVARRL
                     RNSLSSSDEEDFNYPIIQSLSNSLYVYKDIEDQIYNAIISEVEISDNASSTLRDIRRR
                     IAQKNQSIRSKLNSIISSTTYQKYLQDAIISLRGDRFVVPVKSEYRSQVAGIVHDQSS
                     SGATLFIEPMTIVEMNNELRQLKLGEQEEIERILSELSAMVGEVSEDLISNQEILGRL
                     DFAFSKGKLSIQMRGIEPTLNEDKYLNIKNGRHPLLDKKKVVANTIYLGRDFHTLVIT
                     GPNTGGKTVTIKTVGLFALMTQSGLHIPADYGSSMCVYDNVFADIGDEQSIEQSLSTF
                     SSHMTNIVSILQNVTADSLVIFDELGAGTDPVEGAALAIAVLEDINSVGAKCIATTHY
                     SELKNYALTKSGVENAAVEFDIETLSPTYKLLIGVPGKSNAFEISRKLGLSDYVISRA
                     KEYINTENIALEDVLQNVEKNRIKAVEDREEAERLKEEIEKLKVEYDEKLEKLVSQRD
                     KMIEKAKSEAFSIIRQAKEEVDIIIKELRSLEQERASKEKNRKIEELRKELTSSMGSL
                     QPTVKSMIVPKVSNKEIKDLKPGEEVKVITLNQNGSVVSVDKKRKEAVVQIGIMKMTL
                     PFKSLQKTRKDVSTNVTKSTRNIIRSKSGSVKNEVDLRGLNLEEAIMEVEKYLDDAYV
                     AGLESVTVIHGIGTGVLKAGLQDILRRNRHVKSQRGGQYGEGGAGVTIVKLK"
     gene            10937..12388
                     /locus_tag="KRO40_002444"
     CDS             10937..12388
                     /locus_tag="KRO40_002444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-histidine dipeptidase"
                     /protein_id="HBH2093261.1"
                     /translation="MGNVLEGLKPESVFKNFEKISQIPRGSGNEKGISDFLLSFGKNL
                     GLETIQDESLNIIIRKPATKGYENCPGVVLQGHMDMVCEKEKNVEHDFLKDPIKLRID
                     GDMIYATGTTLGADNGIAVAMGMAILEDNTLEHPALEVLVTVNEEDGMNGADALDPSL
                     IKGQYILNMDSEEEGYLLVSCAGGKTCVVSLPVEYKEVKGDKQGLLVEVTGLLGGHSG
                     MEIVLQRANANKAIARVLSVLNVDYELASVDGGTKHNAIPREAKCVIAVNKADVESAK
                     KQINDILTAFKHEFTTSDPGMTYSVAETSVDKVLTKDCKEKVVQMSCLTPHGVQSVSL
                     DIEGLVESSTNFAIIETKESTIEFLTSVRSSVMSIRDEIADRIRLLAQALGANYDLIA
                     QYPAWEFKKGSKLEKICSETYEKLTGKVPTVMALHAGLECGLLLDKLPHAEAISIGPD
                     MFDVHTPNEHVSIPSVANVWDYVIEILKSMNQY"
     gene            complement(12592..15105)
                     /locus_tag="KRO40_002445"
     CDS             complement(12592..15105)
                     /locus_tag="KRO40_002445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH2093262.1"
                     /translation="MEDCVVNLKKLLLLIIVITSIFTSCIFSFGINAIGNDNRTIRVA
                     YPIQKGLTEIDEQGNYFGYTYEYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENG
                     EIDIMGGMLYNEPMQKIYNYAGNNYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVI
                     ENSDTRLKELDEYCKMNLMSPELVYCKTNDEQLEALKSGKADVLLNVSMNPIEGVRTV
                     AKFSSKPFYFITPKGSTNLTQKLNSAINNIEQKDPYFSTTLYEKYFTPENNQMFLSDE
                     ETNYIKETEKLKVGVLLNKPPFQNIDKDTGELRGISIDLLNHICDKTGLEFELVPVKS
                     QEDLENMTKKREIDIVAGMIYDYEYSREHNIAMSRPFLSTQYTMMINNKLNENSLDGK
                     RVALAKGINYYGQFEENIVWYDNLEECIEAVNKGYADYTYGEGYSMQYYMNQPKYKNV
                     RLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISISSEKMQSIVYQNTTYRQDFSLLY
                     IMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEKISLELKKHTQLYEMTSEYFFE
                     YDYKQDKLIISMPEKGIETYYGLDKNDKESENGNIENERDKIRKEYNKKFFDVIKSQE
                     NGTTEMYSIMLDDTFHWIRVTSKIIYNDRKIPMYVIGKICNIDSEKEEKNRLLDKAQR
                     DSLTNIYNAAYIRKLTAQNLLNLSTEKNGALLIIDIDYFKSINDTYGHLLGDKVLIDV
                     AKVLDESFAKNDIVGRLGGDEFSVYINDIINKEELINKCNDVYNHIHLIKLPNGESLS
                     ISMGVVIAKPGQEYDELYQIADTALYDSKRQGRNRFKIV"
     gene            complement(15328..16149)
                     /locus_tag="KRO40_002446"
     CDS             complement(15328..16149)
                     /locus_tag="KRO40_002446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2093263.1"
                     /translation="MIDINLEKCVGCGMCESDCLVNAIKVKDDKAKVKNILCINCGHC
                     MAICPTDAIEMQGFDKNEVIEYNRESFELEPEKLLNFIKFRRSIRQYKDIEVEEEKIK
                     NIVEAGRYTPTGGNRQPIRYILVKEKLKEVKELAIQGLYNLALDTDDNDPVRSMYKNT
                     FKKMYKRYKENGNDSLFYDAPLLMVVVGDMSLGGSAYVDGGLAASNMELMAYSQGLGI
                     CYNGFFVMASNVEPKIKELLGMSENEAVITSFILGYPDVKYKRTVNRNTAKFEVR"
     gene            complement(16668..17144)
                     /locus_tag="KRO40_002447"
     CDS             complement(16668..17144)
                     /locus_tag="KRO40_002447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HBH2093264.1"
                     /translation="MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGET
                     PEECVIREVKEETGLTLKSLSYKGLITFPKFKDEEDWYMFLYFSDEFEGELSEKDLND
                     CKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD"
     gene            complement(17179..17757)
                     /locus_tag="KRO40_002448"
     CDS             complement(17179..17757)
                     /locus_tag="KRO40_002448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBH2093265.1"
                     /translation="MREEALEILFKYLETDRMRKHCYAVEAVMRELAKRLEPEKEEEW
                     AVAGLLHDLDSDIVGRKPGEICEGHATTTVELLKKENFGDEEMYRAILGHHDGMGVTR
                     TSLMEKAIYAADPITGFITAIALVYPDKKLTSVKTKSVIKRMKETRFASNVNRDAMRS
                     IEDIGIPFDEFAELSLNAMKNISDVLESAENN"
     gene            complement(17861..20461)
                     /locus_tag="KRO40_002449"
     CDS             complement(17861..20461)
                     /locus_tag="KRO40_002449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBH2093266.1"
                     /translation="MKKIELLAPVGSFDSLKAAVQNGANAVYLGGKDFSARASANNFD
                     RNELIEAVKYSHIRGVQVFVTVNTLIKQYEIEDFVEYVKFLYDIDIDALIVQDIGMAR
                     LIKKLLPDFELHASTQMVAHSLEDVKYLQSVGFDRVVLARELNVDEIKWICENTTVDI
                     EVFVHGALCVCYSGQCLMSSMIGNRSGNRGRCAQPCRQKYELIDINTGEVVKSNGDYL
                     LSPRDLSTIEDLDKIIEAGVLSLKIEGRMKKPEYVATVVSGYREAINEFVDKKKISIS
                     EEIINNLYTIFNRKFTKGYILGEVGKDIMNSNRPNNQGLYIGKVLDYNRKNKRLRVML
                     ENTLKKGDGINLGGGTIGRIIKDGEITTIAHKGDLIELDFVGEAKRNQLIYKTSDSEL
                     MDRVQATFQQDKEFIKTNIRAKVSIKLGKKPELFISDFCGNKSVVEGDKIVEKAIKVA
                     LSKEKIETQIQKLGNTPYKLKEIEIDLDEGVSMPISVLNQMRRDCIELLDEERIKIKD
                     RKFKKNRLKYQPNRVNKQKKLDTAPKIRVKVKNLEQLEAVLNYNVDLIYYEDINTLSK
                     ALQMVSSISIDSNISIDSSISMDLDTSSSLGTPKELMGSNTNNIDTLSNTSKIDTLNK
                     NHYNTAVTDKKLIYSAPRIVRNKEYKQFEILDNIKGINKVQIGNWGSMEYFKKKDLNI
                     DCYLNAFNSESINHFKEEGASTVCLSQELNLNEIKQTLKYTDVEIEAVIYGYAPMMVT
                     EYCPMGVVVRDCKKDKRVAKCKESSYALRDFTDASYRITQDIFCRSTIYNSKVTCMLD
                     NLYELEEIGIDVFRIDFTVEDSEMVKKVIEAHIEVLSNNYKLGKKATDLYKKLDEIGT
                     VAGHYYKGVE"
BASE COUNT         6483 a         3677 c         2286 g         8120 t
ORIGIN      
        1 ttaaaaagca tataaattga tataattata taatagataa gttaatattg aggagggata
       61 attatggaaa taagagtatt aagatatttt ttagcaattg caagagaaga aagtatatct
      121 ggtgcggcaa cctttttaca tataacacaa ccaactcttt ctagacaaat tatggaactt
      181 gaagaagagt tgggagttaa attattggtt cgaggaaata gaaaaatcac cttaacaaat
      241 gaaggtaggc ttttacataa aagagcagaa gaaattatat cattagttga taaggttgaa
      301 ttagaatttg acaatcccaa tgagattatt agcggtgata tatatatagg aagtggtgaa
      361 actgaagcta tgcgacttat agctagaact gcccatcatt ttcatcaaaa ataccccaat
      421 gtaagatatc acctttttag tgggaatgct gatgatgtga ctgaaaaatt agacaaggga
      481 ctgcttgatt ttggtatttt aattgaacct gcaaatatac agaagtatga ttatgcacaa
      541 attcctgcta ctgatgtatg ggggttacta atgcgtaaag atagtgccct tgcatcacaa
      601 agcacaataa atccaaaaga tttatgcaat atacctctta ttatttcaag acagacactt
      661 gttgataaag caatttctaa atggcttcaa gacagtaatg aaaaactaaa cattattgca
      721 acatacaatt tagtttataa cgcttctctt ttggtagaag aaggtctggg ctacgctctg
      781 tgtttagata gactcgtcaa tactacagaa aacagtaatc tttgttttag acctctatct
      841 cctcctttag aagctaaatt aaatattata tggaaaaaac atcaaatatt ttcaaaggca
      901 gcagaaaaat ttttacttca aatacaaaaa gatttttctt ctatcatgtt ggatacatct
      961 aagttggata cacctaaaga aaaataaatc ataataaaaa gtgagagtgt ctcaaaatga
     1021 actttgcact gtataaggca ctctttttta tacaaagtaa aatatatgtt catcatttca
     1081 gcactaaaaa agaggcttat ctctattttg agatagcccc acttaaccaa taaaattaaa
     1141 tacaacttaa caatatcctt acttatttat tccaagttct cttagacaag caatagtaat
     1201 ttcatcttgt ggatttaatt cataagctct ttctatatag taagttgcat catcaatatc
     1261 accattattt aaataagcca ttcctaaatt gcaaagtatt tctgggtctt cctttatctt
     1321 agccgcttgt tcaaaatact ctattgcttt atctaaatta ttcttataag cctcacaaag
     1381 ccccaattcc actatagtat ccacttgatt aggctttatt atcaatatct tctcaagata
     1441 catcttagcc tgctctattt cgcccatacc cttatatcca agtgctatca taaacagcaa
     1501 gttccaccaa tccatatgtt cttcttctaa tggaagtaac ttctctaatc cttccttaaa
     1561 cttaccttgg aatacaagtg tatatccttc ttcatattga actttaaagt ccatcttgcc
     1621 cagattctct tgtacctcag ctactaaatc agcatctaac cctagcctta acgcttcttc
     1681 ccaagtcagc ttagtcttta aatattgacc ttgattataa taatggtagc ctaagtgata
     1741 ataacctaat gcaaaattct catcaacatc aattaccttt tcaagcttag ccatggcttc
     1801 aagtaagaat gcattcattg ccttatcatc catatctttt tgatactgtt tagctatctc
     1861 ttggcaaaca atcgcatagt tatacattgc atctaaatca tctggataca ttgttataaa
     1921 tgcttttata tatattaaag aatctgtatg ttcaccaatc tcaaagtatt ttctcgacat
     1981 atatcccata tacgatttca aatccaaatc aatatctttt gataaagcat ttaaaaactt
     2041 ctcatactct gcattgtttt taaacttact atctattcca attatatata tcattgcatc
     2101 tgctatagac attgaattta acttatcttg agcagtcttt tcttttatcc cttttactaa
     2161 tacctcattt tttataggta catctaatcc accttttggc acttcatagc tttttaattt
     2221 aaactctcca ccatgtttta tagttataaa agctaattct tctgtttttt ttagcaaata
     2281 tttttctatc ttaaaatcca ttttatcctc ctaaatactt aaatctctac tttatgagtt
     2341 ttagatttct caaatatttt tttatcatca tactcaaata agactacatt ttctacttct
     2401 cttatttctg tatttatatc attttttaaa tccacaacat taaatctaaa tggctcaaaa
     2461 tgaacatatt ttattatatg tttagctggt ttatcaacaa aactaggtaa atatgttgat
     2521 aagttatcat tatcttgtaa aaatacatgg catctattct taaaatcatc cacatctagc
     2581 ttattaaaaa actgtggtat atttgatgtt ttacccagtg atatatagtc atattttaat
     2641 atatcgttga atacatcatt atctatgttg attttttcat tatagaaatc catcaatatt
     2701 ttatataact gattctttcc ttgtgccaaa tcaaagtagc cattttcatc aaaatacttg
     2761 gcaaaaacct caaagaattt aaaagggctt tttttataaa atctgcctat aatatatctc
     2821 atagataaca caaagttttt agaattgtag tatctctcca gtatatcttc tatatccttt
     2881 agcttcaaag tttcttcata gcttatataa ttattgtata aaaactcata tggagcataa
     2941 tccttatatt taaaaccatg ctcatctgca acttttctca tacctgtccc tttaatcatc
     3001 tttaaaaagc ctaattgcaa atgctctata cctagattaa atacatcatt aaaagaattt
     3061 tcaaagctct tataatcttc ataaggcagt cctgcaatta agtctaagtg ctgatgtata
     3121 tttctataag atgctacagt ttgtacaaca tgagacaact ttttaaaatc atcccttcta
     3181 cctactgcat caagtgtttt ttcattcgtt gactgaacac ctatttcaaa ttgaaaaaga
     3241 ccttctttac aatcagccaa aaactcaagc atcttatcat ctatcaaata cgctgtaact
     3301 tcaaaatgat aagttgtata tccattatca tttttcataa ggaaatccat gatttccata
     3361 gccacttttc tatttgcatt gaatgtccta tctataaact ttatttgtga tactcttgca
     3421 tctattaaag cttttaaatc actctttatc ctgtctaaac taaaatacct tagacctgga
     3481 atagtagatg ataaacagta ttggcagtta aaagggcaac ctcttgatga ttcataatac
     3541 actattctat tttcatattc ttttggattc aagttttcat aaggactagg aatctcatcc
     3601 aaattttgaa gtaattccat aggcttattc actattatct cattgccttg tctatataca
     3661 agtccattta catcatttat ttccatcttt ccttgcaagt gaagtactaa gtctctaaaa
     3721 attaattctc cctctccata aagtatataa tccacaaaat catacttttt cattgcctca
     3781 taactatcat aactcacttc cggtccgccc aaagctattt tagtattagg tctaattttt
     3841 tttagattat cacaaagttt aactatatct cccacattcc agatatatgt tgagaataat
     3901 attatatcat attcattttt atatatatcc tttaaaatat agtccaaatc gttgtttatc
     3961 gtgtattctt tcatattaac ttctatcaaa tctcttacaa attcttttag atatcttata
     4021 gccaaatttg tatgaataaa cttggaattt aatgttgtta ataaaatttt caaatatttc
     4081 tcacctcttt ttaagattat actgtctttt tgtacccctt ataggttaaa atagtatatg
     4141 taaagtctaa ataatatcta tataattaat ttattaattt caagtaatgt gaggaaagga
     4201 agttttttat ggaattaatt gaaaaagtat ctatcaactc tttatcaaaa agagatttac
     4261 tacttattat aaagtctctt gaatacacta atgaaaatac tcaaattagt gatttcattg
     4321 accttaggaa taatatagta aaggaattat gttttttaac tgacactaag gaaaaagatt
     4381 ttttagatta tctagaaaaa aatagcacac tctaataacc taaacctttt taaactttaa
     4441 tatataaata cctgatttag aatttatttt tatgcttaat atattatcat taaaggtttt
     4501 cgacataact gttatttgat taaatatagg gtctattata gtattacctt cttcaagtct
     4561 tataagactt cttgggtcta tgcttttatt atatgcctta actccaattt tatattttct
     4621 caatttaaca acatattcgg acatagaaaa aataaaatct atattatctt catttaattt
     4681 actatcttca cccaaaatgg ataatataga tttttttatg ctattaattc cttcattttc
     4741 tacaattcta tcttccatat atacatcata tagaacattt aaaacattta ataaaatact
     4801 ttcttcatca taatcttcag atttcaaatc aatgtactta tcaattaatt gtattgcttt
     4861 aatccttgcc atctgaaact ttacaacatc tgatttgtct aattctatag aaaatcctat
     4921 tatcttgtct ttaatactct gtagtaattc gacatactct attttactat tatttataag
     4981 attgtgcata atggaattat acaccacaga acctaataaa taatcaaata aaagttcttc
     5041 ttttttaaaa taaataacat acttttttat tagtttaata acctcatctt cacttttttg
     5101 aatattagta tttgataaaa ttagtggtaa taaaatattt aaaaaattga tatttcctat
     5161 tttttctcca taaaatctat agtaaataag ttcatctctc agtctatttt cgtctatata
     5221 cacacatctt tgtgttttat catctattaa ggattttgta tttattatag ttaaatcttt
     5281 aagagcccta cttgcactac taaaagaaga tgtgtagact ttttttagta attcgtcatt
     5341 cataaatata tcctttctga aaaattgaat gtaaataaat tgttattaaa aaaaaaagag
     5401 acagcccgtt taagaagctg tcatatatag ggggatagta gtgtacaaaa atcattgtaa
     5461 tctactatct atatattatt atacgatact acttttttat atgtaaagca tcagttttcg
     5521 acatccctat attttacagt tatacaaatt gcgtactaag ttcaatttta ttctttttat
     5581 ttcaacattt tatcatgcta cattctttca ggagcgtgca ttcccaacaa tttcagagaa
     5641 ttttctaaag tttgttttgt tgctaaaact aatgcaagtc ttgcttttct tatttccaaa
     5701 ttttctacta aaattggatt gtcatgataa aatttattaa acgcttgagc taaatctagc
     5761 ataaatctag tcactatatg tggctcattt ttctttagag caagtaaaat attcttattg
     5821 aatgattcta taactctaag aacttctgca ctatcttcat cagctaatag actataatct
     5881 atatcagaag tcacttctac ttctgctttt cttaaaactg cacagcatct agcatgtgta
     5941 tactgaacat atggtccagt ctcaccatca aaactaagcg ttctttccca agagaaggta
     6001 tagtctttaa ttctactatt agataactct tggaatacta ctgccccaac acctacttgc
     6061 ttagatattt catccacatt tttagcattt gggtttttag ctagtataat ttccttagtt
     6121 ttatctatag cttgatttaa agcatcttct aaaaatacta ctcttccttt tctagtcgac
     6181 atagtacctt cttcaagtgc aaccatacca aatccaacat gaattaaatc ttttgcccaa
     6241 tcatatccca taagctcaat taccttaaac cattgttgga aatgtaagtt ttgttgagaa
     6301 ccaactacat atatacactt gtcaaaatca taagtttctt ttctatatat tgcagcagct
     6361 aaatctcttg tcatatataa cgttgaacca tcattcttag taataagtgc tggtggcatt
     6421 ttatactctt ctaaatcaac aattcttgct cctttagact cttttaaaag atttttctct
     6481 tctaatagtt cgataaccct gttcatttta tcagaataaa aactctctcc tgctaaagaa
     6541 tcaaattcta tatctaaaag tttataaact ctgttaaact cttttaaact ctcatttcta
     6601 aaccattgcc ataattcttg tgcttcttcg tcaccatttt ctaatttatt aaaccatgct
     6661 cttgcttcat cttccatttc tgggtgttgt tcagcttcat catggaatct tacgtataat
     6721 tttagcaatt ctggaattgg attagactct actacttctt tttctcccca ctttttaaag
     6781 gccactatta acttaccaaa ctgagttcca tagtcaccta aatgatttat tcttatagtc
     6841 ttgtatcctt gcgaatcata tatcttatat aaagcattac ctataactgt agttcttatg
     6901 tgccctatat ggaaaggttt tgctatattt ggagaagaat attcaactat tacagtttta
     6961 tcttttccaa aatcactatg tccgtaattt tctttttcat ctaaaacttt tttaattaca
     7021 gtttctgcta attgagattt atttacaaag aaatttacat atccgcctaa ttgtattact
     7081 tttgttatct ctccacttgg ttctatactt tccgccaatt cacttgctat catgtttgga
     7141 gcttttctaa acactttggc taatttaaag catggaaaag catagtcccc catatcctta
     7201 tttggtggaa cttctataag tgcctctatc tcttctttcg ataaatcttc tattttttct
     7261 ttaaggcaat ttgatattgc caccttaaaa tcttgcattc tgttgctcct ctctacattg
     7321 ttcctggttt atattgtgct tatctcttta tgttaaatca aatttcgtgt tttttcaagt
     7381 atttcattac agtgtaaaac actttagtaa ttatgttttc tgtatatatt aaaaatacta
     7441 taattgcagt ttttaatcac actattattg attttttata agactttttt ctattttatt
     7501 gtttcttgta ctatccagtt gactttatat acttttttta atcttttatc tattttcata
     7561 cgtcaatgct aattttatat acttttcttt taatctttta ttaattttca tacatcaatg
     7621 ttaactttat atacgttttt ttaatctttt atctattttc atacatcaat gtcagcttta
     7681 tatacttttt ttactctttt atctattttc tataaatcaa tattagcttt atatactttt
     7741 tttactcttt tatctatttt ctataaatct ttttcactct taacttttat tccttcttct
     7801 tctaatagcc ttgctgttat acctttccct ggtatctttt tacctgaaaa actaccatca
     7861 tatattagat tacatccaca agaggggcta ccctctttta gtattgcttc gctacataca
     7921 tataaatttg ctatttttag agtttcatta gcccctctta caaagttttc tgttacatcc
     7981 ttattatctt tagtaattac ttttccatca actatctcag caggtggtct tggtgtagat
     8041 agaccaccta actgctctgg gcatacaagt gtaaattctt tgccttttaa atattccttg
     8101 actttttcat tatcattatt atcgccacta tatttacaat ttattcctat taaacatgca
     8161 gataccaata tcataaaaat gtgctcctat acaaattata tatattctca tacaaattac
     8221 taatgtattc ttatacaaat tattttaatt taacaattgt tactcctgct ccaccttctc
     8281 catattgacc acctctttgt gattttacat gtctatttct tcttaaaatg tcttgtagcc
     8341 ctgcttttaa tactcctgta cctattccat gtattactgt tacagactct aaacctgcca
     8401 catatgcatc atcaagatac ttttctactt ccattatagc ttcttctagg tttaaccctc
     8461 taaggtcaac ttcatttttt acactaccag attttgacct tataatgttt ctcgttgatt
     8521 tagttacatt tgttgaaaca tctttgcgtg ttttttgtaa agatttaaaa ggtagagtca
     8581 tcttcattat accaatttgc actactgctt cttttctctt tttatctact gaaactacac
     8641 taccattttg atttaaagtt attaccttaa cttcttcacc tggctttaag tcttttatct
     8701 ccttatttga tacctttgga actatcatac tttttactgt tggctgaaga cttcccatag
     8761 agctagtcaa ttcttttcta agttcttcta tcttacgatt cttttctttt gaagctcttt
     8821 cttgttcaag acttctaagt tcttttatta taatatctac ttcttcttta gcttgtctta
     8881 taattgaaaa tgcttctgat ttagcttttt caatcatctt atctctttga ctgaccaatt
     8941 tttcaagttt ttcgtcatac tctactttca gtttttcaat ctcttctttt aatctttcag
     9001 cttcttctct atcttctact gctttgattc tattcttttc aacattctgt aacacatctt
     9061 ctaaagctat gttttctgta tttatatatt ctttagcacg tgaaatcaca taatcactta
     9121 gcccaagttt tctagaaatc tcaaacgcat ttgattttcc gggaacacct ataagtaact
     9181 tatatgttgg gcttaaagtt tctatatcaa attcaactgc tgcattttct acacctgatt
     9241 tagtaagagc ataattttta agctcactat agtgagtggt agctatacat ttagctccta
     9301 cagaatttat atcttctaat actgctattg caagggcagc tccttcaaca gggtctgttc
     9361 ccgctcctaa ctcgtcaaat ataactaaag agtctgctgt tacgttttgt aatatagata
     9421 ctatattcgt catatgagat gaaaatgttg atagactctg ttcaatactc tgctcatctc
     9481 ctatatctgc aaatacatta tcatatacac acatactact tccataatca gcaggtatat
     9541 gaagtccact ttgtgtcata agtgcaaata gacctacagt ttttattgta acagtcttac
     9601 cacctgtgtt tggacctgtt atcaccaatg tatggaagtc tcttcctaaa taaattgtat
     9661 ttgctactac cttcttttta tccagcagtg gatgtcttcc attttttatg tttaaatatt
     9721 tatcctcatt taaagttggt tctattcctc tcatctgtat agaaagtttt ccctttgaaa
     9781 atgcaaagtc caatcttcca agtatctctt gattagaaat taagtcttca ctaacttctc
     9841 caaccatagc agaaagctct gataaaattc tttctatttc ctcttgctct cctagtttca
     9901 actgcctcaa ttcattgttc atctctacta tagtcattgg ctctataaaa agtgtcgcac
     9961 cagaagatga ctggtcatgc actataccag ctacttgcga cctatattca gattttacag
    10021 gtactacaaa tctatcacct cttagagaaa ttattgcatc ttgtaagtac ttttgataag
    10081 tagttgaact tattattgaa tttaattttg acctaatgga ttgatttttt tgggctattc
    10141 ttcttctgat atctctaagt gtacttgaag cattgtcaga tatttctact tcactaatta
    10201 tagcattgta tatctggtct tctatgtcct tgtatacata cagagaattt gatagagatt
    10261 gtattattgg ataattaaaa tcttcttcat cactactaga taagctattt cttaatcttc
    10321 tagccactct taaggtatct gctatcataa tcagacttcc tgggtcaaga gaagcaccta
    10381 tataagctct ctttacctta tcttctatat catgaatacc ttccaaccct actgaacctc
    10441 tctttataat aattgattga gcttcactag tttcttctag catagatttc acttctacaa
    10501 aatcagtatt tggtactaaa ttttctatat attttagacc taaagaagat gaggctttct
    10561 tctttaacaa atctattatt ttattgtatt ctagaactct taacgatttc tcattcattt
    10621 tctatattca ccatcctcga tattttaact tttttattta attttaaaaa tgtatgtttt
    10681 caagcatttc caataaaaac tgcaagtttt atttcttttt catttctaaa attattatat
    10741 tttttctctt ttagatatat tttacacata ttttgtatta tactatgtat gtagctatct
    10801 atatattata cataaacatg ctttatttgt aatataatct gttaaaaaat cttctttaat
    10861 atttttaaag gagtttattt tagcttataa aaaaaaatag ctacttatat agataaatta
    10921 aggaggaaca tgagtcatgg gaaacgtatt agaaggatta aaaccagaaa gtgtttttaa
    10981 aaactttgag aaaatatctc aaattcctag aggttctgga aatgaaaaag gcataagtga
    11041 ttttttactt agctttggta aaaatttagg tcttgaaact attcaggatg aaagcttaaa
    11101 cataataata agaaagcctg ctacaaaagg atatgaaaat tgtccaggtg tagttcttca
    11161 aggacatatg gatatggttt gcgaaaaaga aaagaatgtt gaacatgatt ttcttaaaga
    11221 ccctataaaa ttaagaattg atggtgacat gatatatgct actggaacta ctctaggagc
    11281 tgacaatggt atagctgttg ctatgggtat ggctatatta gaagataata ctttagagca
    11341 tcctgcacta gaagttttag ttactgttaa tgaagaagat ggtatgaatg gtgcagatgc
    11401 actagaccct agcttaatta aaggtcaata tatcctaaat atggactccg aggaggaagg
    11461 atacttatta gttagctgtg ctggtggtaa aacttgtgtt gttagtttac ctgttgaata
    11521 caaggaagtt aaaggtgaca aacaaggatt attagttgag gttactggac tattaggtgg
    11581 acactctggt atggaaattg ttttacaaag agcaaatgct aacaaagcaa tagctagagt
    11641 attaagtgta ttgaatgttg attatgaatt agcttctgtt gatggtggta ctaagcacaa
    11701 tgctatacct cgtgaagcta aatgtgtaat agctgttaat aaagctgatg ttgaatctgc
    11761 taaaaaacaa ataaatgaca ttttaactgc atttaaacat gagtttacta cttctgaccc
    11821 tggcatgact tactcagtag ctgaaacttc tgtagacaaa gttcttacta aagattgtaa
    11881 agaaaaagtt gttcaaatgt cttgcttaac tcctcatgga gttcaatcag taagtcttga
    11941 tatagaagga ttagttgaaa gttctactaa cttcgctata attgaaacta aagaatctac
    12001 tattgaattt ttaacttctg ttagaagttc tgttatgtct attagagatg aaatcgctga
    12061 tagaataaga cttttggctc aagctttagg tgctaattac gaccttatag ctcaataccc
    12121 agcttgggaa tttaaaaaag gctcaaaatt agaaaaaata tgcagtgaaa cttatgagaa
    12181 attaactggt aaagttccta ctgttatggc tctacatgct ggtcttgagt gtggattatt
    12241 acttgataaa cttcctcatg ctgaagctat ctctatagga ccagatatgt ttgatgttca
    12301 tactccaaat gaacatgtta gtatcccttc tgtagctaat gtttgggatt atgttattga
    12361 aatattaaaa tctatgaacc aatattaaat ttaagttttg attctaagta gattttaatt
    12421 ttaagtaatc tatataaaat taactctgta aattaatact actgttagta taatatttac
    12481 tttcaatatt aacttataga aataaagcct aatgatagat aataacatgt atcattaggc
    12541 tttattgtaa tttaaatatt attaagcttt attctgtttt aaaattaatt cttatactat
    12601 tttaaatcta tttcttcctt gtctcttaga atcataaaga gcagtatctg ctatttgata
    12661 cagttcatca tactcttgac caggctttgc tataactacc cccatactaa tagataaact
    12721 ttctccattt ggcaacttaa tgagatgaat atgattgtat acatcattac atttattaat
    12781 aagttcttcc ttatttatta tatcattgat ataaacacta aattcatctc cacccaaacg
    12841 acctactata tcattttttg caaaactttc atcaagtacc tttgcaacat caataagtac
    12901 tttatctcct aacaagtgac cataagtatc attaatcgac ttaaaataat caatatctat
    12961 aatcaataaa gcaccatttt tttcagttga taaattcaac aaattttgtg cagttaattt
    13021 tctaatatat gctgcattat aaatattggt taaactatcc ctttgagcct tatctaacaa
    13081 tctattcttt tcctcttttt cagaatcaat attacatatt ttcccgatta catacattgg
    13141 tatttttcta tcattataaa ttatttttga agtaactcta atccaatgaa aagtatcatc
    13201 aagcataata gaatacattt cagttgttcc attttcttgt gattttatta catcaaaaaa
    13261 ctttttatta tattctttcc ttattttatc tctttcattt tctatattgc cattttcact
    13321 ttccttatca tttttatcca aaccataata agtctcaata cccttttctg gcatagaaat
    13381 tatcaattta tcttgcttat aatcatactc aaaaaagtat tcacttgtca tttcatacaa
    13441 ctgagtatgt tttttgagtt ccaaagatat cttctcgttc atacttgtac gagtatgtaa
    13501 accaaatgcc ataaatccaa taatacaaat taataaactg gctacaataa aaatagtctc
    13561 aattggattc tgttgcataa tataaagcaa cgagaaatct tgtctatatg tagtattttg
    13621 gtagacaatt gattgcattt tttctgatga aatacttata atagctttat taaatatatt
    13681 caataattct tgtttatctt ttttaattat accaaaacaa atactctttg ctttataggt
    13741 ttgaggaact agacgcacat ttttatactt aggttgattc atatagtact gcatagaata
    13801 accttcgcca taagtgtaat ctgcatagcc tttattaaca gcttctatac actcttctaa
    13861 attatcatac caaactatat tctcttcaaa ctgaccataa taattaatac ctttggctag
    13921 agctacacgt tttccatcta aactattctc atttaattta ttattaatca tcatagtata
    13981 ttgagtagaa agaaaaggcc gagacatagc tatattatgt tcacgagagt attcataatc
    14041 ataaatcatt cctgctacaa tatcaatttc acgcttttta gtcatgtttt ctaaatcttc
    14101 ttgagatttt acaggcacaa gttcaaattc taagcctgtt ttatcacata tatgatttaa
    14161 caaatcaatt gatatacctc ttaattcacc tgtatcttta tctatatttt gaaatggtgg
    14221 tttgtttaaa agtactccta cttttaattt ttctgtctct ttaatgtaat tagtttcttc
    14281 atcagataaa aacatttgat tattctctgg tgtaaagtat ttttcatata aagtagttga
    14341 aaaatatggg tctttctgtt caatattatt aattgctgag ttaagctttt gagttaaatt
    14401 tgtactacct ttaggagtaa tgaaataaaa tggttttgat gaaaattttg ctacagtacg
    14461 tacaccttct attgggttca tactcacatt aagaagtaca tctgctttac cactctttag
    14521 tgcttctagt tgctcatcat ttgttttaca atataccaat tcaggtgaca taagattcat
    14581 tttacaatac tcatctaatt ctttaagtct agtatcagaa ttttctatta cagcaatacg
    14641 gatttttttc acatcttgtg aactcattat gttatcaata tctgtatttt catataatgc
    14701 ttgtagtact gtatttgcta ctccataatt attccctgca taattatata ttttttgcat
    14761 tggttcattg tataacatac ctcccattat atcaatttca ccattttcta acatcttcat
    14821 taattttgta atagattcat ttatctctcc aggaacttga acaaattcat aattccatcc
    14881 agtatactgt gcaatttcta gtaaatattc atatgtatac ccaaaatagt taccttgctc
    14941 atctatttca gttaaacctt tttgaatagg ataagcaaca cgaatggtac gattatcatt
    15001 acctatagcg ttgataccaa aagaaaatat gcaagaagtg aatatagatg taattacaat
    15061 aattaataaa agtaattttt ttaaattcac tacacaatcc tccatatagt taagatttac
    15121 agtataaatt actgcataaa cttgtagaca tgtaaaaata gattagtata taaaaggata
    15181 tataaatcta cttagaaatt taaatatcct taatatatac aatatattta aattataact
    15241 catttatatg tctattacaa caaatttacc ctgctaaata cctactctat atcccataat
    15301 tttacaagtt gtagtgaagt ttaagttcta tctcacctca aatttagcag tgtttctatt
    15361 tacagttctt ttatatttca catctggata acccaatata aatgaagtga taacagcttc
    15421 gttctcgctc attcctaaca gttcttttat ctttggctct acatttgatg ccataacaaa
    15481 aaatccatta taacaaattc ctaatccttg agaataggcc ataagttcca tattagatgc
    15541 agccaatcct ccatctacat aagcacttcc acctagagac atatcaccta caactaccat
    15601 aagtagtggg gcatcataaa ataaagaatc atttccgttc tctttgtatc ttttgtacat
    15661 tttcttaaat gtatttttat acatagaacg tacagggtca ttgtcatcag tatctaatgc
    15721 caaattataa agaccttgta ttgccagttc tttcacttct tttagctttt cttttactaa
    15781 tatgtatctt ataggctgtc tattaccacc tgttggtgtg tatctaccag cttccactat
    15841 gttttttatt ttttcttctt ctacctctat atctttatat tgtcttatac ttcttctaaa
    15901 tttaataaaa ttcaataact tttcgggttc taattcaaaa ctttcacgat tgtattctat
    15961 tacttcattt ttatcaaatc cttgcatttc tattgcatct gttgggcaaa ttgccataca
    16021 gtgaccacag ttaatacaga gaatattttt aacctttgct ttatcatcct taacttttat
    16081 tgcatttaca agacagtctg attcacacat accacagcct acacattttt ctaaatttat
    16141 gtctatcatt ccaaattatt cctcctttta aaaaatttac tttagtataa aacaaatagt
    16201 tgtctaagtc aatttttatt tttttaacaa tatactagcc ttaactacac tttaatggag
    16261 aaaaatatac ataaattgga acttaaatta gaacttattc aaagtaaaag ataaaagaag
    16321 tagatgtcta aaagtgaact ttttagttaa ttagatattc tttattgtat gaaatcaagt
    16381 ggatatttat catttcaaca ataaaaaagg cttacctcta ttttggatat gtccctgtca
    16441 agtagacaga ctaaaaaaag gctatcttta tgcactgaga tagccccttt tcccaactac
    16501 tattgtttat tttaatatta tatcaataaa tttaatttgc tataacctgt aagttacatt
    16561 ttaatttgat gtaactttaa attacatttt taagtagtat ctttaaatta tattcttaaa
    16621 atatatcatt aaactacatt ttaattaatc taaaaactat atcttaatta atctaagaaa
    16681 cttacattat aatcttttag tttcccatta tcatatacaa tctttgcact aaagatattt
    16741 ccagtcttag cccaatttaa gaacagcctg tcaccttccc acatatttaa atcgaatatt
    16801 ttatcattat caacccaaat taaatttcct tctttacaat catttaaatc tttttcagat
    16861 aattcacctt caaactcatc tgagaaatac aaaaacatat accaatcttc ttcatcttta
    16921 aattttggaa aagttatcaa ccctttatat gacaatgatt taagagtaag accagtctct
    16981 tcttttactt ctctaattac acattcttct ggagtctctc cttgctcaaa ctttcctcca
    17041 actcctacat acttaccttc atgtatatca tctttctttt tatttctgta cagcatcaaa
    17101 gtcttgtcat ctttttctat ataacaaata gttgtaagtt tcatgtatct cgccttgctt
    17161 tctcttttat attctcaact aattattttc agcactttca agcacatcac ttatattctt
    17221 cattgcatta agagaaagct ctgcaaattc atcaaatgga atccctatat cttctatact
    17281 tctcattgca tctctattta catttgaagc aaatctcgtt tctttcattc ttttaataac
    17341 agacttagtc tttacactgg taagtttttt atctggataa actaaagcta tagcagttat
    17401 aaacccagtt atagggtctg ctgcatatat tgctttttcc attaggctag ttcttgtaac
    17461 tcccattcca tcatgatgac caagtattgc tctatacatt tcttcgtcac cgaagttttc
    17521 ttttttaagc agttctactg ttgttgtagc atgtccttca catatttctc ctggctttct
    17581 tccaactata tctgaatcca aatcatgtaa aagacctgcc actgcccact cttcttcttt
    17641 ttctggctct agtcttttgg ctaattctct cataacagct tcaacagcat aacaatgttt
    17701 tctcattcta tcagtttcta aatacttaaa taaaatttct aaagcttctt ctctcatttt
    17761 caccaatccc cctgtttttt cacatatatg atatttttat atattaatac acataaattc
    17821 aagtttttat atatattcat gtatattttt catgttatat ctattctaca cctttatagt
    17881 agtgtcctgc aactgttcca atttcatcta atttcttata caagtctgta gccttttttc
    17941 caagtttata attattactc aatacctcaa tgtgagcttc aataaccttt ttaaccatct
    18001 cactatcttc aactgtaaaa tctatcctaa atacatctat tccaatttcc tctaactcat
    18061 atagattgtc caacatacaa gtaaccttcg aattgtaaat tgtacttcta cagaatatat
    18121 cttgtgttat cctataactt gcatccgtaa agtctcttaa agcataacta ctttccttac
    18181 atttagcaac tctcttgtcc tttttacaat ctctaacaac tactcccata ggacagtatt
    18241 ctgtaaccat cataggagca tatccatata ttactgcttc aatttctaca tctgtatatt
    18301 ttaaagtttg tttaatttca tttaagttta gttcttgtga caaacaaact gtacttgctc
    18361 cctcttcttt gaagtgattt atactttcac tattgaatgc atttaagtag caatctatat
    18421 ttaagtcttt tttcttaaag tattccatag agccccagtt accaatttga accttattaa
    18481 ttccttttat attatccaat atctcaaatt gcttgtactc tttatttcta acaatccttg
    18541 gtgctgaata gattaatttt ttgtcagtga ctgctgtatt atagtggttc ttattcaaag
    18601 tatctatttt acttgtattt gacaaagtat ctatgttatt tgtatttgaa cccattagtt
    18661 ctttaggagt acctaaagac gaagaagtat ctaaatccat agaaatactt gaatctatag
    18721 aaatatttga atctatagaa atacttgaga ccatttgtaa agcttttgat aatgtattta
    18781 tatcttcata atagattaaa tctacattat aatttaatac tgcttctaat tgctccaagt
    18841 tcttaacttt aactctaatc ttaggagctg tatcaagttt tttctgttta tttactctat
    18901 ttggctggta ttttaatcta ttcttcttaa attttctatc ttttatcttt attctttctt
    18961 catctaaaag ctcaatacaa tcccttctca tctgatttaa cacacttata ggcatactta
    19021 caccttcatc caggtcaatt tctatctctt ttaacttata tggtgtattt ccaagctttt
    19081 gaatttgtgt ttctattttt tctttactta aagccacctt tatagctttt tcaactattt
    19141 tgtctccttc taccaccgat ttatttccac aaaaatcact tataaaaagc tctggctttt
    19201 tacctagttt aatactcact tttgcacgta tattagtttt tatgaactct ttatcttgct
    19261 gaaatgtagc ttgtactcta tccattaatt cgctgtcaga agtcttatat ataagctgat
    19321 ttctctttgc ttctccaaca aaatctaatt ctatcaaatc ccctttatgt gctattgtag
    19381 ttatctctcc atcctttatt attcttccaa tagtacctcc acctaagtta attccatcac
    19441 ctttcttaag cgtattttct agcattactc taagtctttt gttctttcta ttataatcta
    19501 aaacttttcc aatatatagc ccttgattat taggtctatt agagttcatt atatccttac
    19561 caacttcacc taatatatat ccttttgtaa actttctatt aaatatggta tacaaattat
    19621 ttattatttc ctcagaaata cttatttttt tcttatctac aaattcatta atcgcttctc
    19681 tatatcctga aaccacagta gctacatact ctggcttttt cattctacct tcaattttta
    19741 aagataatac acctgcttca attattttat ccaaatcttc tatagtactt aaatctctag
    19801 gactcaacaa ataatctcca ttacttttta ctacttctcc tgtatttata tctatcaact
    19861 catacttttg tctacatggc tgtgcacacc tacctctatt tcccgaccta ttgcctatca
    19921 tactactcat aaggcattga cccgagtaac atacacataa agctccatgt acaaaaactt
    19981 ctatatctac agttgtattt tcacaaatcc attttatctc atcaacattt aattctcttg
    20041 ctaaaacaac tctatcaaac cctacactct gaaggtattt tacatcttct aaggaatgtg
    20101 ctaccatttg agtgcttgca tgtagttcaa agtcaggtaa tagttttttt ataagtcttg
    20161 ccattcctat atcctgtact attaaagcat caatatctat atcgtataaa aattttacat
    20221 actctacaaa atcttctatt tcatactgtt ttatcaatgt atttacagta acaaagactt
    20281 gcactcccct tatatgagag tatttaacag cctcaatcag ctcatttcta tcaaagttat
    20341 ttgcagatgc tctagcacta aagtctttac cacctaaata cacagcattt gctccgtttt
    20401 gaactgctgc ttttaatgaa tcaaaagagc ctactggtgc aagtaattct atttttttca
    20461 tatttttctc ctctatttat acttgttagg ttaatataat tatatctata acttaaatat
    20521 ttgtattaaa tttatatatt tcttactata ttttaaattc ttcaat
//
LOCUS       DAEQCW010000070        19945 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.070, whole genome shotgun sequence.
ACCESSION   DAEQCW010000070 DAEQCW010000000
VERSION     DAEQCW010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19945)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19945)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19945
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.070"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            407..1198
                     /locus_tag="KRO40_002450"
     CDS             407..1198
                     /locus_tag="KRO40_002450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LamB/YcsF family protein"
                     /protein_id="HBH2093267.1"
                     /translation="MYKVDLNSDLGESFGTYKIGLDEEVLKYISSANIACGFHAGDPS
                     HMEKTVQLAKKNGVKIGAHPGFLDLIGFGRREMKITKQEAKDYTKYQLGALMAFASSN
                     GCNIQHVKPHGALYNMAAKDKELAMGICEAIYEVDKDIILLGLYNSEMINSAKEIGLR
                     FANEVFADRAYDNNGFLVPRNVEGAVIHDTKHAIDRVVRMVKEGTVETLTGEVIHIKA
                     DSICVHGDNPKAIEFVKEIRKRFELEGIEVCPLENIEVCSSENIV"
     gene            1227..2447
                     /locus_tag="KRO40_002451"
     CDS             1227..2447
                     /locus_tag="KRO40_002451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HBH2093268.1"
                     /translation="MSTKNITDKTKNKKDVGALIGAAFIMATSAIGPGFLTQTAQFTQ
                     DFGPNFSFVILITTILFIGAQVNVWRVIGVSGLRGQDIANKIIPGLGYLVAFLVALGG
                     LAFNIGNVGGAALGMNVMFNMNMTLGTVLSGLIAIFVFMSKNSNSLVDKITKFLALGM
                     IIIVGYVAISNHPPVGEAVSRMVKPENPKGLIFPIITLLGGSVGGYITFAGGHRLIDG
                     GITGEENIKEITKSSLLGILVATMMRVLLFLAILAVVSKGLQLDPENPAASAFKFSAG
                     AIGYKFFGLVLWSAAITSVIGAAYTSVSFLKTLNPFIDKYEKYFIIAFIAISTLIMAF
                     IGKPATLLILAGALNGLILPITLGIMLIASKRKDIVGDYKHPTWLLIFGLIVVLISAY
                     TGITSLSSLGALFA"
     gene            2467..3162
                     /gene="pxpB"
                     /locus_tag="KRO40_002452"
     CDS             2467..3162
                     /gene="pxpB"
                     /locus_tag="KRO40_002452"
                     /EC_number="3.5.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-oxoprolinase subunit PxpB"
                     /protein_id="HBH2093269.1"
                     /translation="METRYLISGDKAVVAEFGNEISEDINKKVISFMRAIEISNLKGI
                     VTEMVPTYRSLMISYNPLEIDFDSLIENLKKIEDNLESIVLPKPKIHEIPVCYDEVFG
                     IDIKNVASYNNLTVDEVIKIHTSREYLIYMLGFTPGFPYLGGMDERIATPRLEVPRTK
                     IYGGSVGIAGSQTGVYPIDSPGGWQIIGRTPLKLYDENREEQILLRAGDFIKFVPITL
                     DEFIEIEKNNLSI"
     gene            3192..4178
                     /locus_tag="KRO40_002453"
     CDS             3192..4178
                     /locus_tag="KRO40_002453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin-dependent carboxyltransferase"
                     /protein_id="HBH2093270.1"
                     /translation="MGFKVELGGFQTLIQDRGRVGYGQYGVSGCGAMDEYAHRVGNIL
                     VGNSEDEASLEVLMLGPTITFDEYTQIAVTGGDLGAKINGKEIQNWRSYQINPGDVLS
                     FRGVKSGARAYVSIAGGIDVPLAMGSKSTYTRAKIGGFEGRALKKGDYINTFIQEKDF
                     TINKKLSSKYIPTYSSEIVLRIVKGPQFDAFSNGEVEKFLSNKYKVTNEIDRMGCRLD
                     GESIKHLNGADIISDGISYGAIQVPGHGKPIIMLSDRQTSGGYTKIGNVISVDLYKLA
                     QAKPNDVVKFELVDIYEAHRLLREQEDKIQDIYKSMKNIRVVKAKVLNDIAV"
     gene            complement(4373..4939)
                     /locus_tag="KRO40_002454"
     CDS             complement(4373..4939)
                     /locus_tag="KRO40_002454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093271.1"
                     /translation="MLGEKMRNIRKSKKKTLSDVSKLTDLSISYISQIERDAIEPSLS
                     SLRKIAEVLDTPLYMFMDDNNTDDLVIRKEDRVMMKFPKSEMFYEIVSPMPTTEFTPS
                     ILFVEFELKPESEDAKDYIYHASEEIMVVTSGVVDICMGEKVVRLNPGDSTFIKANVP
                     HKIINPSKDTIARGYGVISPPIWPIKSK"
     gene            5291..6358
                     /locus_tag="KRO40_002455"
     CDS             5291..6358
                     /locus_tag="KRO40_002455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide epimerase"
                     /protein_id="HBH2093272.1"
                     /translation="MKITDIKFEKLRIKLKKPVVVSFGVIEYGESIILKIETDEGYCG
                     FGEAAPLAAVTGEVLDNVLSVLLMFKKELIGKDPLDIETIHTIMDGIIIGNTSAKAAI
                     DIALYDIKGKIMNAPLYKVLGGFDSKVQTDITISIDKPEKMAVEALERVKEGFRILKL
                     KAGINPEDDIEAVKLIREAVGESIRIRIDANQGWNVNSSINTIKKLEEFNVDAIEQAL
                     PHWDLDGTAYIRNKSNTKIMIDESLHSPIDAIKAIKKNAVDTFNIKLMKSSGIYPAIK
                     INNIAEASGVNCMLGCMLETRIGITAAANLIASKKNITEADLDSFMFCEELEGISGGF
                     VMDGDIMNLVNKPGLGIEVNL"
     gene            6377..7537
                     /locus_tag="KRO40_002456"
     CDS             6377..7537
                     /locus_tag="KRO40_002456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBH2093273.1"
                     /translation="MNTLFSNPGSILAVMTSMIALGFYLQRYKAIKSLGPALTIIIMG
                     IILSNLKVVPVSTELYGTISTYAIPISMTIMLMSVDLKEMTKLSREPLIAIFVAVLTV
                     SIMAFLFGLVFAEKISEGWKVAGMFVGTYTGGSANLTAIGTGLNVSRQTLAAANAADY
                     VIGVPTLIFMFALPAILKNSKKFKKLWPYHVEESELEDCQNEEFMESKEWSIKDIAWM
                     LAIGFVVTEVSTILAGYFNSSFSSAARILLVTTISIIIAQLKPVKKLKGNLDLGLFVA
                     LFFLCTIGFSVDIKEFLGSTFTITLYCFSIIFASFVFHLGITRLLKIKYQYVILSIVG
                     AIADGPTSALVAASAKWNSLVSVAVVMGVIGGVLGNYAGISVAYAIKMSLGL"
     gene            7550..9646
                     /locus_tag="KRO40_002457"
     CDS             7550..9646
                     /locus_tag="KRO40_002457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CocE/NonD family hydrolase"
                     /protein_id="HBH2093274.1"
                     /translation="MIKFKLYISGLYSGNVIFDGDLLIEKLNPFTNKIESLKPISKEE
                     NTYYLNLTKIDLKSLFNNFDVYTKSLVNTDKDTVINNLGETHSKLNEYIWVQRNKKFP
                     LDIIIVDNKIVGFICLSRETCTILIMDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMI
                     DMKDGIKLSTDVYLPDFVDSAKKAPTILMRTPYGKENDKEIYYKYVQRGYAVVIQDVR
                     GRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKH
                     LKALVSIVTSGSPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRP
                     IENIPVEALGYRIEFLEEWLKRVEKDEYWDLMDWHLQKDKINVPALVVSGWYDDNSMG
                     TTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWFDKY
                     LKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLV
                     FDNDLEEKYDSYIYNPKDPSVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEF
                     TVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGILSARFRNSFYKSEFMEE
                     GEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNTIY
                     HGGKYPSKLILPIENK"
     gene            complement(9805..10149)
                     /locus_tag="KRO40_002458"
     CDS             complement(9805..10149)
                     /locus_tag="KRO40_002458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH2093275.1"
                     /translation="MEIKRYEGTGRMSRAVVHNNTVYLCGQTHAEGGVIEQTTEVLAK
                     IEDLLNKYGSDKQHLLSVTIYLRDMKDFEAMNSVWDAWVEKGFEPARACVEARLAREH
                     LLVEMSVVAATK"
     gene            10441..11331
                     /locus_tag="KRO40_002459"
     CDS             10441..11331
                     /locus_tag="KRO40_002459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH2093276.1"
                     /translation="MSSTIKSNRIKGIMFIIASALGFAMMSAFVKLAGDLPSFQKVFF
                     RNLVSAIIAFWLIIKHKGSLTGKKENLKVLLYRSIFGTLGVIFNYYAIDKLMLSDANM
                     LNKMSPFLVVIFCAIALKEKINVKQIGAIIIAFIGALFIIKPTFSVEVIPYLGGIAGA
                     VFAAMAYTCLRVLGDREDYYTIVFFFSVFSLVTVGPIAFAVYEPMTLMQLIYLLLGGV
                     FASLGQFGITLAYKYAPAKEISIFDYSNIIFSAILSIFLFNVYPDMLSVVGYLIVFSA
                     AFYMFLYNKKLDKLDKEKKK"
     gene            11549..12835
                     /locus_tag="KRO40_002460"
     CDS             11549..12835
                     /locus_tag="KRO40_002460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH2093277.1"
                     /translation="MEKVKVAVIGAGNRGTYAYAPYIYENSDVCEIVAVAEPKKGRRE
                     LFTQKYNLDSKNVFETLEDFFKHDKMADAVIIATNDDRHYDVAKLALEKGYHVLLEKP
                     MSNSLDGLVHIDDLCDKYKDKIFMICHVLRYSPFYNKLKEIVESKKLGELVSIQYNEN
                     IGYWHFAHSFTRGNWRNSNETSPLILAKSCHDMDILLYLVGSRCKKISAFGSLKHLNN
                     QNASGEMAQNCLQCLVEKKCPYSAKRIYLEKDRSINRAVHINPTEENLLNILKTSPYG
                     RCVYRCDNNVVDNMVNILQFENGVTATFNLCAFTKENGRTIKLMFSHGEVGGDLNKNE
                     IRIKEFGKNEEIVMNPSNQQNMVEEYDRNLIAEFIKLVSNKELEKGRVAAKEAIQSHV
                     MAFAAEYSRVSDEVVYIEEFFDSAKQMTKEIEETIF"
     gene            complement(12924..13367)
                     /locus_tag="KRO40_002461"
     CDS             complement(12924..13367)
                     /locus_tag="KRO40_002461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory YrvL family protein"
                     /protein_id="HBH2093278.1"
                     /translation="MIKISNKRRIPLGEFISVFLFFAVFFGITFCIFTVIGIGFLSFL
                     GFEYKSLGAVLIFFLIYFCITTPIDFLCTTILDIFRYVNKLPYSIYKLCEFIIDFILT
                     FLAMNIIDTFMDSVTIPLSTEILFALLSYLLSECMDFFDRDKKKP"
     gene            complement(13391..14185)
                     /locus_tag="KRO40_002462"
     CDS             complement(13391..14185)
                     /locus_tag="KRO40_002462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M55 family metallopeptidase"
                     /protein_id="HBH2093279.1"
                     /translation="MKLYLSADIEGTCGIVNWDETKLECEFSQHYRTQMSKEITAACD
                     GATQSGVHEILVKDAHDSGRNINPNILPENVKILRGWTKDPLVMMAGIDESFDACIFT
                     GYHSGATCNGNPLSHTMDIDYDYFKINDEIASEFTINAYIAAYYNVPVAFLSGDEMLC
                     ESAKKLNPNIVTVPVSKGIGNGSISIHPNLALKKIEKGVKKALSGDLSRHLIKLPDKF
                     KIEIKFREHYKAFKASFYPNMKKIDSQTVLFETEDYYEFLRMLLFI"
     gene            complement(14751..15227)
                     /locus_tag="KRO40_002463"
     CDS             complement(14751..15227)
                     /locus_tag="KRO40_002463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBH2093280.1"
                     /translation="MKEILINPIGKICIQGEEVFIKLDKKYVPALNELDDFSHLNVFW
                     WADGFDNPELRSILETPKPYKSGPDVIGIFATRSPIRPNPIALTAVQIINIDHENGII
                     KIPYIDANDNSPVIDLKPYTPSVDRVENPSVPKWCSHWPKSVEKSGEFNWEDEIEF"
     gene            complement(15328..16497)
                     /locus_tag="KRO40_002464"
     CDS             complement(15328..16497)
                     /locus_tag="KRO40_002464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093281.1"
                     /translation="MLNIKTLCHEINDWVINIRRDLHKTPELGLEEFQTKKKIIKYLN
                     EIGINYIEYKNHTGITAYINVSPNFETVAIRADIDALPITEELNYSYKSINIGKMHAC
                     GHDAHTAILLGTCNILFKLKDYLNVNVKFFFQPAEETIGGAQLMIEDGCLEKPNVKYI
                     FGLHVNPNINKNLIELKYNTLNASTNTLQLTVHGSKCHGAYPHQGIDAIVISAHIITA
                     LQTIVSRNTNPTDSVVISLGKIEGGIKENIVCDKVVIRGTLRTLTPETREFSKKRIRE
                     ICDFTCKTFGGSISVEIEEGYPALINSNHLVDYVKQNAVELFGEENIILKDSPTLGAE
                     DFSYFLRHCEGAFYHLGCANREKNITSPLHTSTFDIDEDCLITGVMLHVKNVLSF"
     gene            16660..17523
                     /locus_tag="KRO40_002465"
     CDS             16660..17523
                     /locus_tag="KRO40_002465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HBH2093282.1"
                     /translation="MLGIIAPSGPLRNTSLEEIKFNLESYGYEVKFSESCSLNYKGYL
                     AGNDDIRARDIEDMFLDKDVDIIMCLRGGYGTTRILDKINYDIIKQNPKPFIGFSDIT
                     GLNLAFYKNCGLLPYHGIMAANVGKWGKFTYKSLVNALEFKDELYLENPKEEKIYTVC
                     EGKAEGIIMGGNLSLIIATMGTKYEIDAKDKILFIEEIGEPQYKLDRMLTQLYSSGKL
                     EECNGIIFGDFKDCIEENDLMELLIEFANKVNKPSIYNLQSGHCIPMITIPLGRMCEL
                     DATEKIVKLKK"
     gene            17594..18187
                     /locus_tag="KRO40_002466"
     CDS             17594..18187
                     /locus_tag="KRO40_002466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3867 domain-containing protein"
                     /protein_id="HBH2093283.1"
                     /translation="MSDDRIIDFNELKNKVKDSDVDKFEQYIYNLYFSVMDGKMSMAE
                     FSRKIFDYMRDNNISQEKFMKIQKQFMERYGMDTEEVEKQLRNFGIDPSTAGFMSNNT
                     SSKVSTEDLESFKKSAGFYEKYGEKIQPKSCITTFIKNDLNDINVIIDQEKIMLCSDR
                     KINLMDSELNEFLLEYKNMFNKKIKVVMCETTNKYDY"
     gene            complement(18438..19073)
                     /locus_tag="KRO40_002467"
     CDS             complement(18438..19073)
                     /locus_tag="KRO40_002467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBH2093284.1"
                     /translation="MDNLLNELEALKSNLDNLPIEKIENYDLSKTALFIIDVNNGFAR
                     QGALYSPRVESLIKPIEMFTKKISNKLNRVIAFTDSHTPKSIELLSYPVHCLENDVES
                     ELVDELKSIENLQILPKNSTNGFFALENLDFDNIDNIIIVGDCTDICIYQFAITLKSY
                     FNQHNIEKNIVVPMNLVDTYDIPNVHPAEILNLVFFNSMIQNGVNVLKEIR"
     gene            complement(19153..19884)
                     /locus_tag="KRO40_002468"
     CDS             complement(19153..19884)
                     /locus_tag="KRO40_002468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBH2093285.1"
                     /translation="MNIYAHRGFSGKYPENTILAFKKCLDMDIYGIELDVHRTKDGKI
                     VVIHDEKVDRTFNGHGFVKDFTLRKLKTLNSSFEGYQSNKECKIPTLEEVLILISPTD
                     LTLNIELKTDKINYPNIEKGVLELILKYNMKNRVLISSFNSNSLKNFHKLDPSVKTGL
                     LCYLPINNVVNFAKFLGNSYLHPPLVLVNESLIELCHKNLLGVNVYTVNEEDDILHCL
                     KLNVDGIFTNYPDIASNLLHSKQYS"
BASE COUNT         7593 a         2332 c         3327 g         6693 t
ORIGIN      
        1 ttataaaaat ataaagatat tttacttaca aagaatgata attatataga tgaaagaaac
       61 aaatgaatga agaaaaatga ttctgtcttg catataaagt gattaaaaat gaaaaatact
      121 ttaaaaatga aggttaaagc ccttatttta agtgaaaata attaattatt aactaaaaaa
      181 tggtaaaaag attttttgaa aaagaaatac aaatgaatgt tcaattaaaa taattgcaaa
      241 aatattcctt aaatggtaaa attatattaa ttaaatgcaa tagaatagtt gcaaaaataa
      301 aattgaatac aagtgataaa atatttcatg caatatataa aataaacaaa atttaaaaat
      361 taaaactact tattctatca aaatgttagc gaggaggggt cataaattgt ataaagtaga
      421 tttaaatagt gatttaggag aaagttttgg aacgtataag attggtttag atgaagaagt
      481 tttaaaatat atttcatcag ccaatatagc ttgtgggttt catgcaggtg accctagtca
      541 tatggaaaaa acagtacagc tagctaaaaa aaatggagtg aaaataggcg cacatccagg
      601 tttcctagat ttaataggat ttggaagacg tgagatgaaa ataacaaagc aggaagctaa
      661 agattataca aaatatcaac tgggtgcttt aatggcattt gcaagttcaa atggatgtaa
      721 tatacaacat gtaaaaccac atggagcatt atacaatatg gcagctaaag ataaagagtt
      781 agctatgggg atttgtgaag ctatatatga agtcgataaa gatattatac tgttggggct
      841 atataatagt gaaatgataa attctgctaa agaaattgga cttaggtttg caaatgaagt
      901 atttgcagat agagcttatg ataataatgg ttttttggtt ccaagaaatg tagaaggagc
      961 agttatacat gatacaaaac atgcaataga tagggttgtt aggatggtaa aagaaggaac
     1021 tgtagaaact ttaacaggtg aagttataca tatcaaagca gattctatat gtgtacatgg
     1081 ggacaatcca aaagcaatag agtttgtcaa agaaataaga aagcgttttg aattagaagg
     1141 tatagaagtt tgtccattag aaaacataga agtttgttcg tcagagaaca tagtataaga
     1201 ctgataacat gagggggaga taaaatatga gtacaaaaaa tattacagat aaaactaaaa
     1261 ataaaaaaga tgtcggagca cttatagggg ctgcatttat aatggcaaca tcagcaattg
     1321 gaccagggtt tttaactcag actgcacaat ttacccaaga ttttggaccg aatttttcat
     1381 ttgtaatttt aattacaaca atccttttta taggggctca agtaaatgta tggagagtaa
     1441 ttggtgtatc aggacttaga ggtcaggata tagcaaataa aataatacct ggattaggct
     1501 atttagtagc ttttttagta gctcttggag gattagcttt taatatagga aatgttggtg
     1561 gagctgcact tggtatgaat gtaatgttta atatgaatat gacattagga actgtattaa
     1621 gtggattaat agctatattt gtatttatgt caaaaaattc aaattctcta gtcgataaga
     1681 taactaaatt tttagcatta ggaatgataa ttatagttgg atatgtagca atatcaaatc
     1741 atcctcctgt tggagaggca gtatcaagaa tggtaaaacc agaaaatcca aaaggactga
     1801 tattcccaat aataacttta cttggaggaa gtgttggagg ttatataact tttgctggag
     1861 gacatagatt aatagacggt ggaataacag gagaagaaaa tataaaagaa ataactaaat
     1921 cttctctttt gggtatatta gttgccacaa tgatgagagt tcttttattt ttagcaatac
     1981 tggcagtggt ttcaaaaggt cttcaacttg acccagaaaa tccagcagct tcagctttta
     2041 aatttagtgc aggagcaata ggatataaat tctttggact tgtattatgg tctgctgcaa
     2101 ttacatcagt tataggagct gcttatacat cagtttcttt cttaaagaca ctaaatcctt
     2161 ttatagataa atatgaaaaa tattttataa tagcatttat agcaatatca acacttataa
     2221 tggcatttat aggaaaacca gctactttat taattttagc aggagcttta aatggattga
     2281 tacttccaat cacattagga attatgctta tagcatctaa aagaaaagat attgttggag
     2341 attacaagca tcctacatgg cttttaatat ttggattaat agtagtttta atatctgcat
     2401 atacaggaat aacttctctt agcagcctag gtgctttatt tgcttaattt agaagaggtg
     2461 acatttatgg aaactagata cttgatatca ggggataagg cagtggttgc tgaatttgga
     2521 aatgagatat cagaagatat aaacaaaaaa gtaatttcat ttatgagagc aatagaaata
     2581 tcgaatctta aaggtattgt aacagaaatg gtaccaacat ataggtcact tatgataagt
     2641 tataatccat tagaaataga ttttgatagt ttgattgaga atttaaaaaa aatagaagat
     2701 aatttggaaa gtatagtatt accaaaacct aaaatacatg agattccagt atgttatgat
     2761 gaggtttttg gtatagatat taaaaacgtt gcaagctaca ataatctcac tgtagatgaa
     2821 gttataaaaa tacacacaag cagagagtac ttgatatata tgctaggttt tactcctgga
     2881 tttccatatc taggtggtat ggatgaaaga atagctacac ctagattaga agtgccaagg
     2941 actaaaattt atggtgggag tgttggaata gcaggttccc agactggtgt atatcctatt
     3001 gatagtcctg gtggatggca aataattggt aggacacctt taaaattata tgatgaaaat
     3061 agagaagaac agattttgct tagagctgga gattttataa aatttgttcc aataacatta
     3121 gatgaattta tagaaatcga aaaaaataac ttaagtattt aaatatcgtt atagtacagg
     3181 gagtggtata tatgggattc aaagttgaat taggaggttt ccaaacatta atacaagaca
     3241 gaggtagagt tggctatggt caatatggtg tatctggatg tggagcaatg gatgagtatg
     3301 cacatagagt aggaaatata ttagtaggaa attctgaaga tgaggcttct ttagaagttt
     3361 taatgttagg tcctacaatt acctttgatg aatatacgca aatagcagta actgggggag
     3421 atttaggggc taaaataaat ggaaaagaaa ttcaaaactg gaggtcatat caaataaatc
     3481 caggtgatgt attatcattt agaggtgtga aatcaggtgc tagagcctat gtgtcaatag
     3541 ctggtggaat agatgttcca cttgcaatgg gaagtaagtc aacttataca agagctaaaa
     3601 ttggtggatt tgaaggtaga gcacttaaaa aaggagatta tataaatact tttattcagg
     3661 aaaaagattt tacaataaat aaaaaattaa gttcaaaata tattccaact tatagttcag
     3721 aaatcgtact aagaattgta aaaggtcctc aatttgatgc tttttctaac ggtgaagtag
     3781 agaaattttt atcaaataaa tacaaagtta cgaatgaaat agatagaatg ggttgtagac
     3841 tagatggaga gagtataaag caccttaatg gagcagatat tatatctgat ggtatttctt
     3901 atggagctat acaagtacct ggtcatggaa aaccgattat aatgttatca gatagacaga
     3961 ctagtggtgg ctatactaag atagggaacg ttataagtgt agatttgtat aagttagcac
     4021 aagcaaagcc aaatgatgta gtaaaatttg aacttgtaga tatatatgaa gcacatagac
     4081 tattgagaga gcaagaagat aagattcaag atatctacaa gagtatgaaa aatataagag
     4141 ttgtaaaggc aaaagtatta aatgatatag cagtttaatt ttaacaaata caatttttat
     4201 tataatttat aatataactt acaaatagct atttactatt taccataatt aagatggttt
     4261 agattagtca aatagctatt tttttagttt gagtaaatat tttaaattta aaataaaagc
     4321 aatatttaaa tctattatat tatctacaaa aagtaggtgt gtcatattga gtttatttag
     4381 attttattgg ccaaattgga ggtgatataa ctccatatcc acgagctatt gtatctttac
     4441 ttggattgat gattttatgt ggtacattag cttttataaa tgttgagtca cctggattta
     4501 atctaactac cttttcaccc atacaaatat caaccacacc actcgttacc accataattt
     4561 cttctgatgc atgatatata taatctttgg catcctcact ttctggttta agttcaaact
     4621 ctacaaataa aattgaaggt gtaaactcag ttgtaggcat tggagatact atctcgtaaa
     4681 acatttcact ctttggaaat ttcatcataa ctctatcttc ttttctaatg actaaatcat
     4741 cagtattatt gtcatccata aacatatata aaggagtgtc taaaacttca gcgatttttc
     4801 tcaatgaaga caaggatggt tcaatagcat ctctttctat ttgagagata taacttatag
     4861 ataaatctgt caatttggaa acatcactta atgttttttt cttgcttttt cttatatttc
     4921 tcatcttttc acctagcata agaacctcca aataataaaa ttaatataaa atattcgctt
     4981 aaaacaaagt aattatagca caacatagaa gtagtggcaa taagaataca tagtagattt
     5041 tgacaattaa aatttaatta aatccaaata aaagtctatg aaaatgaatt attgttaaat
     5101 taatacaaag aaaataataa taaaaaaatt taatagaaga gtattaattg aattaagatt
     5161 atcacattat attttggaaa agagtaaatt ttcagtaaat tatcttgaca tatatattga
     5221 agtaataata taatttaaag tataaaattt taaaaattga attataactt caaaaaataa
     5281 ggagggtaat atgaagataa cagatatcaa atttgaaaag cttagaatta aattaaaaaa
     5341 acctgtagta gtttcatttg gagtaattga gtatggagaa agtataattt taaaaattga
     5401 aactgatgaa gggtattgtg gatttggcga agcagcacct cttgcagcag ttacaggtga
     5461 agttttggat aatgttcttt cagtattgct tatgtttaaa aaagagttaa taggcaaaga
     5521 cccactagat attgaaacca tacataccat catggatgga attattatag gtaatacttc
     5581 tgcaaaagca gctattgaca tagctttata tgatattaaa ggaaaaatta tgaatgcacc
     5641 tctttataaa gttcttggag gatttgatag taaagtccaa acggatatta ctataagtat
     5701 agataagcca gaaaaaatgg cagtagaagc tttagaaaga gtaaaagaag gttttaggat
     5761 attgaagctt aaagcaggta taaatcctga agacgatatt gaagctgtaa agttaattag
     5821 agaagccgtt ggagagagta taagaattag aattgatgca aatcaaggat ggaacgtaaa
     5881 tagcagtata aatactatca aaaagttaga agaatttaat gttgatgcaa ttgaacaagc
     5941 acttccacat tgggatttag atggtactgc ttacataaga aataaaagta acacaaaaat
     6001 tatgatagat gaatcattac attcaccaat agatgcaatt aaggctataa aaaagaatgc
     6061 agttgataca tttaatatta agctgatgaa atcaagtgga atatatcctg ctataaaaat
     6121 caacaacata gctgaggcaa gtggagtaaa ttgtatgtta ggatgtatgc tggaaacgag
     6181 aattggtata acagcagcag caaatttaat agcatctaaa aagaacataa cagaagctga
     6241 ccttgatagt tttatgtttt gtgaagaatt agaaggtata tctggaggat ttgtaatgga
     6301 tggagatatt atgaatcttg tcaataaacc aggtttagga atagaagtaa acttatgata
     6361 aatttggagg ttaaatatga atacactttt ttcaaatcca ggtagtatac ttgctgtaat
     6421 gacatcaatg attgcattgg gtttttactt acaaagatac aaagccatta aaagcttagg
     6481 accagcactt acaataatca taatgggaat aatactttca aacttaaaag tagttccagt
     6541 aagtactgag ttatatggaa ctatttcaac atatgctatt ccaatttcta tgactataat
     6601 gttgatgagt gttgacttaa aagaaatgac aaaattatca agagaacctt taattgcaat
     6661 ttttgtagct gtattaactg taagtatcat ggcattttta tttggattag tatttgcaga
     6721 aaaaatatca gaaggttgga aggttgctgg aatgtttgta ggtacatata ctggtggaag
     6781 tgctaatctt acagctattg gaacaggtct taatgtaagt agacaaactc ttgcagcagc
     6841 aaatgcagca gactatgtaa ttggagtacc aacattgata tttatgtttg ctctaccagc
     6901 aatattaaaa aattcaaaga agtttaaaaa actttggcca tatcatgtag aagaatcaga
     6961 attagaagat tgtcaaaatg aagaatttat ggagtcaaaa gaatggagta ttaaagatat
     7021 agcttggatg ttggctatag gttttgttgt tacagaagtt tcaacaatac ttgctggata
     7081 tttcaattca agttttagta gtgcagcaag aatactttta gttacaacaa tttcaattat
     7141 aattgctcaa ttaaagccag taaagaaact aaagggaaat ttagatttag gattatttgt
     7201 tgcattattc tttttatgta caataggttt ttcagtagat ataaaagagt ttttaggttc
     7261 aacttttact ataacacttt actgttttag tataattttt gcttcatttg ttttccattt
     7321 aggcataact agacttttaa agataaagta tcaatatgta atactttcta tagtaggagc
     7381 aattgctgat ggtcctactt cagctttagt agctgcttct gcaaagtgga attcgcttgt
     7441 aagtgtagca gtcgtaatgg gagtaattgg tggagtatta ggaaattatg caggtatatc
     7501 agtggcatat gcaataaaga tgtctctagg attatagggg ggagtttaat tgataaaatt
     7561 taaattatac atatctggac tatacagtgg aaatgtaatc tttgatggag atttattaat
     7621 tgaaaagttg aatcctttta caaataaaat agaaagttta aaaccaataa gcaaagaaga
     7681 aaatacatat tatttaaatc ttacaaaaat agatttaaag tctttattta ataattttga
     7741 tgtatatact aaaagcttag taaacacaga taaagacaca gttataaata acttaggaga
     7801 aacgcattct aaacttaatg aatatatatg ggttcaaaga aacaaaaagt tcccactaga
     7861 tataattatt gtagataata aaatagtagg ttttatctgt ttatctagag aaacttgtac
     7921 tatattaatt atggatggat atgaagagta tactgtatta aaagaatggg aaaaaactca
     7981 taaaaatgaa gagatatatt ctataagatt tggtggaaat tatatgattg atatgaaaga
     8041 tggtataaaa ctttctacag atgtatatct ccctgatttt gtagattctg ccaaaaaagc
     8101 accgacaatt cttatgagaa ctccatatgg aaaagaaaat gataaagaaa tatattataa
     8161 atatgtacaa agaggatatg ctgttgtaat acaagatgtt aggggaagaa atgaatcaga
     8221 aggtaagtgg gaacctatga ttcatgagag ggaagatgga gatagtacca taaattggat
     8281 agtatcacag gaatggtcaa gtggaatagt tggaatgctt ggagcatcat atcttggtta
     8341 tgtccaatgg gcagctgcat cttcaggcaa taagcatctt aaagctttag ttagtatagt
     8401 aacatcagga agccctttta ttgatatacc aagaaaagga ggagcttttg tatctggtat
     8461 gcttgcatgg gcatttatgg tatcaagaaa taaagttgat agaagcaaaa tggtaagaga
     8521 tgattgggat gatgttttaa acatacgacc aatagaaaat atacctgttg aagctcttgg
     8581 atatagaatt gaatttctgg aagaatggtt aaagagagta gaaaaagatg agtattggga
     8641 tttgatggac tggcatttac aaaaagataa aataaatgta cctgcattgg ttgtatctgg
     8701 gtggtatgat gataatagta tgggaactac agaggcctta gatgttataa aggactatga
     8761 aaaaggaaag agaaaggcta ttctaggtcc atggatgcat aattcaaata ctttaagaga
     8821 tataaatggt atttctttag gaaatagttc attaagatat gatttggatt ataattatct
     8881 attatggttt gataaatact taaaaggtat agaaaataac atagatacga ctgctccagt
     8941 agagtattac tctgtaggtt ctaataagtg gaagacagaa gaaaattggc caataataaa
     9001 taagatagat aaaagtatgt atctaataag tgatggaaat gctaacacat ctttaggaaa
     9061 tggtagatta gtatttgata atgatttaga agaaaagtat gatagttata tatataatcc
     9121 aaaagaccca tcagtacaac taattgatat gtcagagaat gaagttggag ttccaaataa
     9181 ctacaaagat ttagaaaaaa gaagtgatat gttgtgttat acatcagatg cttttagtga
     9241 agaatttact gtaacaggtg atataaagtt agagtttttt gcatcaagtt ctgccaaaga
     9301 tactgactgg gttataaaaa ttatggacgt ggatttagat ggaaattcaa ttaaattagc
     9361 tgatggtata cttagtgcta gatttagaaa tagtttttat aagtcagagt ttatggaaga
     9421 aggagagatt tataagttta cgattataac ttcaaaaata tcaaacacgt ttaaagttgg
     9481 tcataaaatt agactagata taacgtctag tgctaaaaac tttattttcc aaaatagcaa
     9541 cacgacagag ggatataata gtattgaata tatagaagca aagaatacga tttaccatgg
     9601 aggtaaatat ccatctaaat tgatattgcc aatagagaat aagtaaattt atatagatta
     9661 aatagtgagg aggtgtctca aaatgaattt tttagttcgt gagacacttt cttttatacg
     9721 aaatcaaata tattttcatc atttcaacaa tgaaaaagag gcttatctct ctgttttgag
     9781 atagcctcct ataagctaaa ttgattattt tgtagctgca acaacgctca tttcaactaa
     9841 caaatgctct ctagcaagtc tagcttcaac acaagctcta gcaggttcaa atcctttttc
     9901 aacccaagca tcccaaacag agttcatagc ttcaaagtct ttcatatctc ttaaataaat
     9961 agtaacagat agcaaatgtt gcttatctga accatatttg tttaataaat cttctatttt
    10021 agctaaaact tcagttgttt gttcaattac tcctccttca gcatgagttt gtccacataa
    10081 ataaactgta ttgttatgaa ctacagctct actcattctt ccagttcctt catatctctt
    10141 tatttccata ttttaaatac ctccatagtt aaaaaatcta ttaaaaatct aaataataaa
    10201 ttaaaaaaag tctatactat ataaaattat attatatatt ctgataataa tccataaaaa
    10261 catataactt tttagctata attattattg ttattaattg aaaagattta ttagttactt
    10321 gacatagttt acacttttaa ttatagtata aattggaata tttagataat tattatttaa
    10381 tgtataagct aagtttttaa ttaatatggc tttatacatt tatatagaaa agaggtacgt
    10441 atgagtagca caatcaaatc aaatcgaata aaaggtataa tgtttataat agcatcagcg
    10501 cttggctttg caatgatgtc tgcattcgta aagctagctg gagatttacc aagttttcaa
    10561 aaagtgttct ttagaaatct ggtatcagct ataatagctt tttggcttat cataaaacat
    10621 aaaggaagtc taactggtaa aaaagaaaat ttaaaagtac ttttatatag gtcaatattt
    10681 ggaactctag gagttatatt taactactat gcaattgaca agttgatgct ttcagatgct
    10741 aatatgctaa ataaaatgag tcccttcctt gtagtaatat tttgtgcaat tgctctaaaa
    10801 gaaaaaataa atgtaaagca gataggagct attataattg catttatagg agctttattc
    10861 ataataaaac caacatttag tgtagaagta attccatatc ttggaggaat tgcaggagct
    10921 gtatttgcag caatggcata tacttgttta agagttcttg gagatagaga agattactat
    10981 acaattgtat ttttcttttc agttttttca ttagttactg tagggccaat tgcttttgca
    11041 gtatatgaac caatgaccct tatgcaactt atatatctat tactaggtgg agtatttgca
    11101 agtctaggtc aatttggaat aactctagca tataaatatg cacctgctaa ggaaatctct
    11161 atatttgact atagtaatat aatcttttca gcaattttaa gtatattctt attcaatgtc
    11221 tatccagata tgttaagtgt tgttggatat ttaatagtat tttcggcagc attttatatg
    11281 tttttataca ataagaagtt agataaatta gacaaagaaa agaagaagta aactagataa
    11341 aagtgttttt ataatttgta tttaatattt aagtctttgt attaaaatta aagaaaattt
    11401 aattaaaaat gtttggtata ttaacttata acagcagtta aaattgaaaa attataactg
    11461 ctgtttcttt tattaaaaat atccaaatgt ctgtaaaaat agactataat agagtagtat
    11521 aaataatata aaggggataa attaaagtat ggaaaaagtg aaagttgctg tgattggagc
    11581 aggtaataga ggaacgtatg catatgctcc atatatttat gaaaattctg atgtatgtga
    11641 aatagttgct gtagcagaac ctaaaaaagg aagacgagaa ctatttacac aaaaatataa
    11701 cctagatagt aaaaatgtat ttgaaacttt agaagacttt tttaaacatg acaagatggc
    11761 agatgcagta ataatagcta caaatgatga tagacattat gatgtagcaa aactagctct
    11821 tgaaaaaggt tatcatgtac tattagaaaa gccaatgtct aatagtttag atggtctggt
    11881 acatatagat gacttgtgtg ataagtataa agataagatt tttatgattt gccatgtact
    11941 gagatattct ccattttata ataaattaaa agaaattgta gaaagcaaaa aattaggaga
    12001 gctagttagt atacaatata atgaaaatat aggatattgg cattttgcac atagctttac
    12061 tagagggaat tggagaaata gcaatgaaac cagcccttta attttagcaa agagttgtca
    12121 tgacatggat attttgttat atttagtagg aagtagatgc aaaaaaatat ctgcatttgg
    12181 aagcttaaag catcttaata accaaaatgc tagtggagag atggcacaaa attgtcttca
    12241 gtgtttagtt gaaaaaaaat gtccatattc agcaaagaga atttatttag aaaaagatag
    12301 aagtataaat agagctgttc acataaatcc aactgaagag aatctattga atatacttaa
    12361 gacaagtcca tatggaagat gtgtttacag atgtgataat aatgttgtag acaatatggt
    12421 aaatatacta cagtttgaaa atggagtgac ggctactttt aatttatgtg catttactaa
    12481 agaaaatgga agaactataa agttaatgtt tagccatggt gaagttggtg gggatttaaa
    12541 taaaaatgag ataagaatta aagaatttgg aaaaaacgaa gaaatagtta tgaatccatc
    12601 aaatcaacag aatatggtag aggaatatga tagaaatctt atagctgaat ttattaaatt
    12661 agtttcaaat aaagaactag aaaagggtag agtagcagca aaagaagcta tacaaagtca
    12721 tgtaatggca tttgcagcag aatattctag ggtcagtgat gaagtagtgt atatagaaga
    12781 attttttgat agtgctaagc aaatgactaa ggagatagaa gaaactatat tttaattaat
    12841 aaaaatttat taaataaaat aaagatagat taaataatag aaatacgaaa atatgtgttc
    12901 tattaaggaa tctatctttt ttattaaggt tttttcttat ccctatcaaa aaaatccata
    12961 cattctgata aaagataaga aagtaaagcg aataagattt ctgtacttaa aggaatcgtt
    13021 actgaatcca taaaggtatc aattatgttc atagctagaa aagttagtat aaaatcaatt
    13081 ataaattcgc aaagtttata tattgagtat ggtaatttgt ttacatatct gaatatatct
    13141 aaaatagtag tgcatagaaa atcaattgga gtggttatac aaaaatatat taaaaagaaa
    13201 attaatacag ctccaagaga tttatattca aatcctaaga atgataagaa gccaattcct
    13261 ataaccgtga aaatacaaaa agttatacca aaaaaaacag caaaaaataa aaatacagaa
    13321 ataaattcgc ctaaaggaat ccttctttta ttacttatct taatcaactc cttaatttat
    13381 gatatgaaat ttatataaat aataacattc ttaaaaattc ataatagtcc tctgtttcaa
    13441 atagtactgt ttgagaatct atttttttca tatttggata aaaagaggcc ttaaaagctt
    13501 tataatgttc tctaaatttt atttctatct taaatttatc tggcaatttt attaagtgcc
    13561 tagataaatc tccagataaa gcttttttga cacctttttc aatttttttt agtgcaaggt
    13621 ttggatggat tgaaattgaa ccatttccaa ttccttttga cacaggaaca gtgactatat
    13681 ttggatttag tttttttgca ctctcacaaa gcatttcatc tccacttaaa aatgctacag
    13741 gaacattata atatgcagca atataagcat ttatagtaaa ttcagatgct atttcatcat
    13801 ttattttaaa atagtcataa tcaatatcca tagtatgaga aagtggatta ccattacaag
    13861 tagctccaga gtgatagccg gtgaatatac atgcatcaaa gctttcatca attcctgcca
    13921 tcataactag tgggtctttg gtccatcctc taagtatttt gacgttttca ggtaaaatat
    13981 ttggattaat atttctacca ctgtcatgtg catctttaac aagtatttca tgtacaccag
    14041 attgagtagc tccatcacat gctgctgtta tctctttact catttgcgtt ctatagtgtt
    14101 gcgaaaattc acattcaagt tttgtttcat cccaatttac aataccacaa gtaccttcta
    14161 tatcagcact taaatacaat ttcataatat ataccccctt atgtttatta ttgatgataa
    14221 taacagataa cagaaaatac ataatcaata aagggcataa aaatattatg tcttactatt
    14281 aactattatt aaatctgtaa ctgaaaaata actaaattgg tataaaaaaa tataacacta
    14341 tgtgtcattt atttatatag ttttttatat ttgatgttta tataaaattg taacatataa
    14401 gtggttacat ttactagttt aacatagtta aaatagttag gtattatttt taagttaaat
    14461 tgattattat aaaatcgcag aataaaagaa aaatttaatt tattaaaatg catgaaatgt
    14521 tttttcctca acataatgct aaattaaact caaaaagaaa taatagaaaa atcttatgta
    14581 gcttagaaag aatgtgaatg atttaaggga aaaatagaaa tttattatat aatattaggt
    14641 tgtattatat aatacagcct aatattatat gtatatgtga cataaaatct tggtaagtgt
    14701 aaataaaata aatgtggaaa acaagttaat gaaatcaaga aaaaagtaat ttaaaattca
    14761 atttcatctt cccaattaaa ttctcctgat ttttctacac tcttaggcca gtgactacac
    14821 catttaggaa cggacggatt ttcaacccta tcaacgcttg gagtatatgg ctttaagtca
    14881 ataacaggac tattatcatt agcatcaata tatggtattt ttattatgcc attttcatgg
    14941 tcgatattga taatttgtac agcagtcaat gctattggat tgggtcttat aggtgacctt
    15001 gttgcaaata ttcctataac gtctggtcca cttttataag gttttggggt ttctaaaata
    15061 cttcttagtt caggattatc aaacccatca gcccaccaaa atacatttaa atgactgaaa
    15121 tcgtcgagtt catttaatgc aggtacatac tttttgtcta atttaataaa gacctcttcg
    15181 ccttgaatac atattttacc tataggattt attaatattt ctttcataat attacctcca
    15241 actatttaat ttatcatttg taattttagg gtataacatg acatcatgtg agggtcaata
    15301 taaaataata aataaaaata ttaatagtta gaatgataat acatttttta catggagcat
    15361 gacaccagta ataaggcaat cttcgtcaat atcaaaagta gaggtatgca aaggggaagt
    15421 aatgtttttt tcacgatttg cacaaccaag gtggtaaaaa gctccttcac agtgtcttag
    15481 aaaatacgaa aagtcttcag caccaagagt gggcgagtct ttaaggataa tattttcttc
    15541 accaaacaat tctacagcat tttgtttgac gtaatctact agatggtttg aattgataag
    15601 agctggataa ccttcctcaa tttcaacaga aatacttcct ccaaatgttt tacaagtaaa
    15661 atcgcaaatt tctctaattc gtttttttga aaactctcta gtttcaggag tcaaggttct
    15721 caaagtaccc cttataacca ctttgtcaca aactatattt tctttgattc caccttcaat
    15781 ctttcctaga gaaataacca cagaatcagt tggatttgtg tttcgactaa cgattgtctg
    15841 tagagctgta ataatatgag cagatataac aatagcatca ataccttgat gtggataagc
    15901 tccatgacat tttgaaccat gtacagttaa ttgaagtgta ttggtggaag catttagagt
    15961 gttgtatttt aattcaatta gatttttgtt gatattggga tttacatgga gtccaaatat
    16021 atattttaca tttggttttt caagacatcc atcttctatc ataagttgag ccccaccaat
    16081 agtttcctca gcaggttgaa aaaagaattt tacatttaca tttaagtaat cctttaattt
    16141 aaatagtata ttacaagtac ccagtaaaat agcagtgtgt gcatcatgac cacatgcatg
    16201 cattttgcca atattaatag atttataaga ataattaagt tcttctgtta taggtaaggc
    16261 atctatatca gctcttatag caactgtttc aaagtttgga ctcacgttaa tgtatgcagt
    16321 tatccctgta tgattcttat attcaatata atttatacct atttcattta agtatttaat
    16381 aatttttttc ttagtttgaa attcttctaa tccaagttct ggagtcttat gtaaatctct
    16441 tcttatattt ataacccaat catttatctc atgacaaaga gtttttatat taagcataaa
    16501 acacatccta actatattaa aaatttattt ttcttcatta attatattat tttatgtaaa
    16561 tcattattat gtatcaagta caaataaaat atcttataat tatattagag atatttagta
    16621 tggagaagaa tatatcattt tataagaaga ggtgtttaaa tgttaggaat aattgcgcca
    16681 tctgggccat taagaaatac aagtttggag gaaataaagt ttaatttaga aagttatggt
    16741 tacgaagtta agttttctga aagttgtagt ttaaattata aaggttattt agctggtaat
    16801 gatgatatta gagcaaggga tatagaagat atgtttttag ataaagatgt agatataatt
    16861 atgtgcttaa gaggaggtta tggaacaaca agaatattgg ataaaataaa ttatgatata
    16921 ataaagcaaa atccaaaacc atttataggt ttttctgata taacaggttt aaatttagct
    16981 ttctataaaa attgtggtct tttaccatat catggaataa tggcagcaaa tgtaggtaaa
    17041 tggggtaaat ttacctataa atcattggta aatgctttag aatttaaaga tgaattatat
    17101 ttagaaaatc caaaagaaga aaagatttat actgtatgtg aaggtaaagc agagggaata
    17161 ataatgggag gaaatttatc cttaataatt gccacaatgg gaacaaaata tgaaatagat
    17221 gcaaaagata aaattttgtt tattgaggaa attggagaac ctcaatataa actggataga
    17281 atgttaacac aactatattc ttcaggaaaa cttgaggaat gtaatggtat aatttttgga
    17341 gattttaagg attgtattga agaaaatgat ttgatggaat tactaataga atttgcaaat
    17401 aaggtcaata aaccttctat atataatctt cagtcaggac attgtatccc aatgataact
    17461 attcctttgg gcagaatgtg cgaattagat gctacagaaa aaatcgttaa attaaaaaaa
    17521 tagtgtgtat ataaatataa tagaaatatg gtataatctt atacaagtaa aaatttagct
    17581 aggaggatga aaaatgtctg atgatagaat aatagacttt aacgaactaa agaacaaagt
    17641 taaagattct gatgtagata aatttgagca atacatatat aacttatatt tttctgttat
    17701 ggatggaaag atgtctatgg ctgagttttc aagaaaaata ttcgattata tgagagataa
    17761 caacatatct caagaaaaat ttatgaaaat acaaaagcaa tttatggaga gatatggtat
    17821 ggacactgaa gaagtagaaa aacaacttag aaactttgga atcgaccctt ctacagcagg
    17881 ttttatgagt aataatactt ccagcaaagt atctacagaa gatttagagt catttaagaa
    17941 gagtgcagga ttttatgaga aatatggaga aaaaatccaa ccaaagagtt gtataacaac
    18001 atttataaaa aatgacttaa atgatattaa tgtaataatc gaccaagaaa agataatgct
    18061 ttgtagtgat agaaaaataa atcttatgga ttcagaacta aatgagtttt tattagaata
    18121 taagaatatg tttaataaaa aaataaaggt agtaatgtgc gaaactacga ataagtatga
    18181 ttattaaaaa atgaatttaa atactgaagt agtataaatt aattgtacta cttaaaaata
    18241 aaaatcgcaa tttattattc cttataaatt tgtataagga atatctaaac tgcgattttt
    18301 tatattgtga agattagtaa taatagatag tgttttaaat tgtaatcttc tcactaaaac
    18361 tgtgtttttc tattagaaat tttattaaaa ataaatatct gataattgta ttatatggga
    18421 tgtaaagtat tagaagctta acgaatctct tttaatacat taactccatt ttgaatcata
    18481 ctgttgaaaa atactaagtt taaaatctca gcagggtgaa cgttaggaat atcataagta
    18541 tctactaaat tcataggtac aactatattt ttttcaatat tatgttgatt aaaatatgat
    18601 tttagagtta ttgcaaattg atatatacat atatctgtgc aatcgccaac tataattata
    18661 ttatctatat tatcaaaatc caaattttct aatgcaaaaa atccattagt agaattttta
    18721 ggaagaattt gtaggttttc tatcgactta agttcatcaa ccaattcact ttctacatca
    18781 ttttccaaac agtgaacagg ataactcaaa agttctattg atttaggagt atgagaatca
    18841 gtaaatgcta ttactctatt taatttgttt gatatttttt ttgtaaacat ttcaattggc
    18901 tttattaaag actctactct aggagagtat aatgcacctt gtcttgcaaa gccattatta
    18961 acatcaatta taaataaagc agttttactc aaatcataat tttctatttt ttctattggt
    19021 agattatcta aattactctt taaagcttca agttcattta ataagttatc catagttata
    19081 cctccaagat aaatttaata aaattgtaca tattaattat ataaaagtca aggagtacaa
    19141 actattgtat aattagctgt attgttttga gtgtaaaaga tttgaagcaa tatctggata
    19201 gttagtaaaa ataccatcta cattgagttt tagacagtgt agtatatcat cctcttcatt
    19261 tacagtatat acattgacac caagtagatt tttgtgacaa agttcaatta gagattcatt
    19321 tactaaaact agaggtggat gaagataact attacccaga aatttagcaa aattgactac
    19381 attgtttata ggtaaataac acaataatcc tgtttttaca ctagggtcta atttatgaaa
    19441 gttttttaag ctattgctgt tgaaactaga tataagaact ctatttttca tattatactt
    19501 taaaataagc tctaaaacgc ctttttctat attgggatag tttattttgt cagtttttag
    19561 ttcgatattt aaagtaaggt ctgtaggtga gattagaatt aatacttctt ctaaagttgg
    19621 aattttacat tctttattgc tttgatatcc ttcaaaagat gagtttagag tttttaattt
    19681 tcttaaagta aagtctttta caaaaccatg tccattaaaa gttctatcaa ccttttcatc
    19741 atgaataact acaatttttc catccttagt tctgtggaca tcaagttcta ttccatatat
    19801 atccatatcc aaacattttt taaaagctag aatagtattt tctggatact ttccactaaa
    19861 ccccctatga gcataaatat tcatttatat ggttccctcc tataagtata acttatctta
    19921 taaaaattta attaatataa tatat
//
LOCUS       DAEQCW010000071        19720 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.071, whole genome shotgun sequence.
ACCESSION   DAEQCW010000071 DAEQCW010000000
VERSION     DAEQCW010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19720)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19720)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19720
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.071"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(488..1489)
                     /gene="trpS"
                     /locus_tag="KRO40_002469"
     CDS             complement(488..1489)
                     /gene="trpS"
                     /locus_tag="KRO40_002469"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HBH2093286.1"
                     /translation="MSEKKVIFSGAQPSGKMTLGNYLGAIKNWTELQDNYDCYYSIVD
                     LHAITVPQDPKVLRANTIELLAQYIACGLDPEKNTIFIQSHVKEHVELMWVLNTMTYM
                     GELSRMTQFKDKSQKSEANLNAGLFTYPVLMAADILLYQTDLVPVGDDQKQHLELARD
                     LANRFNNRFSPTFVVPEGYYPKGGARVMSLQEPTKKMSKSDSNENAFILLADDSDSIK
                     RKIKRSVTDSLGVVKYNDEQPGIKNLIDIYSNLSKKSVEEIVNMYEGKGYGIFKEDVA
                     EVVSEALRPIREKYVDLLNNKDYLEKIYSMGAEKAEKQARKTLRKVYKKVGFIERRY"
     gene            complement(1512..2210)
                     /locus_tag="KRO40_002470"
     CDS             complement(1512..2210)
                     /locus_tag="KRO40_002470"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HBH2093287.1"
                     /translation="MNVIGIIGAMDEEVSILVDLMDIRETIKKASLEFYKGILEGKNV
                     VLVKCGIGKVNSALCAQILISEFKVDAIVNTGVAGALNEKLDVNDIVISTDAIQYDVD
                     TTAFGDPKGVIPRMKTSVFKADERLIDAAYKSSVEEVKTHKVLKGRVVTGDKFINSKE
                     LKEELVNDFGGYCGEMEGGAIAHVCYLNNTPFVIIRAMSDKADGSADVTYDVFVHDAA
                     NNSKDIVLNMLKSI"
     misc_binding    complement(2253..2493)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(2584..3987)
                     /locus_tag="KRO40_002471"
     CDS             complement(2584..3987)
                     /locus_tag="KRO40_002471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2093288.1"
                     /translation="MEKKKIGLWSLVFMNVSALYGIRWIAKSTASSFGLGLGAIPMWL
                     LFSFIYFVPGALICAELASTYQKGDGGLYDWVKEAFGEKYGFLVSWLNWTAKIFWYSS
                     FLTFLAVNVSYTIGNPALADNKMFVLILSLIIFWALSLIATKGISFTKIFTNTGALGS
                     TIPSAILIIFSFVAVFVLKKHDIASTYTIASMTPKLNMDAFVAISAIMFGLAGAETAA
                     NFITEIDKPEKNFPKAILISAGIVASLYVLGSIAITMIIPPDQITASKGVLDALSAVC
                     ASLGIGSWLVQLIAFGIAFSVLGAIVLYIASPIKMLFGSVKKGIFPDSLVEVNEHKIP
                     SKAVILQAIIVTIILLVTTLMPSVDAIYNVLVTMTALTALFPYVLLYASYIKLRKERP
                     DEIRPYTMAKSTSTCLGLAKMVLVVTVVGILLSAAPVMPTFAENVIYEIEMIGGGLLV
                     ILSGLWLWNRYEKKTAK"
     gene            4484..5560
                     /locus_tag="KRO40_002472"
     CDS             4484..5560
                     /locus_tag="KRO40_002472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2093289.1"
                     /translation="MKAQRLNAVLEQMKKDDISQMLVSDPTSIFYLTGVLIHPGERLL
                     ALYLNLNGNNKLFINELFPVSEDLGVEMVWFNDTQNPVEIITEHIDKNATMGVDKNWP
                     ARFLLNLIELGGGSKFVNSSYIIDTLRMCKDEEEKELMRIASKLNDKAMEQLKATVSG
                     ELTEKQLVGKLSKIYEDLGTDGFSFDPIIGFGPNGANPHGEPGNALVKPGDAIILDIG
                     CIKDNYCADMTRTVFYKEIPEKGREIFEIVLEANKRAEAIVKPGVRFCDIDAAARDYI
                     TEKGYGQYFTHRTGHSIGLEVHDKGDVSSINTDTVQPGMIFSIEPGIYLPGEFGVRIE
                     DLVLVTEDGCEILNKHDKEICVVG"
     gene            complement(5677..6519)
                     /locus_tag="KRO40_002473"
     CDS             complement(5677..6519)
                     /locus_tag="KRO40_002473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH2093290.1"
                     /translation="MDKIKLIVDSACDLPDDIIEKYNIEVVGLNVSFGEESYISGKEI
                     DNETFYRKMSESKVLPKTSCPSPDKFLEAYHCQEESVLVINISSGLSGTYNSALLAKD
                     MFEKEGNNKKVEVIDSLSGSIGIGQLVLKAAILIKEGKEIEEIVSIINKYKDNPPFFG
                     TLETLENAIKGGRINPIAGKIINTLNFKAIIQVADGVVTPIDKARGEGNSLKKLITLV
                     ESKIKDKEEKVLFIGHANCPEKAQKVREVMEKNVKYKDVVICEIGSVMGTYTSKGAIL
                     ITAI"
     gene            6703..7275
                     /locus_tag="KRO40_002474"
     CDS             6703..7275
                     /locus_tag="KRO40_002474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093291.1"
                     /translation="MKTNNMKQAILSSATNLIAKNGVQNTSLADIAKDVNISKGTLYY
                     HYASKDDIIYDIADTHLEVITSAILNCVKNVKSKNSQIEMVNLILEKISTIESRGRVH
                     MYLICEAITSNNDLKERIRLKYIEWRTTLKSEIVESLEKYNSSENEQDAESFSFLLMS
                     IVDGLVVQSLLKTEKIPYENIASFLVNHWI"
     gene            complement(7438..7710)
                     /locus_tag="KRO40_002475"
     CDS             complement(7438..7710)
                     /locus_tag="KRO40_002475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093292.1"
                     /translation="MLRERFVVRNHHNPHTSGCCGTGGEGCCGGDNHEHSHQHSHSHG
                     HEHEHVNGVGHDHNHDDGFSGTHEHSHEHTHTHGHEHSDVHTHEHK"
     gene            complement(7837..8709)
                     /locus_tag="KRO40_002476"
     CDS             complement(7837..8709)
                     /locus_tag="KRO40_002476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2093293.1"
                     /translation="MYGESKKLSIDNNIFLQYCLIILGMILSTLGINLYLAPAKLLSG
                     GVAGICVILYKLFGINQGISSFLMNIPIFIIARKYFDNKFLLISFVNMLLFSLALGLT
                     QDIAKYFPIDDTMLQCIYGGALTGIGMGLTFKARATAGGLDIIAAIMKRKYDIPMKNT
                     FLFINFFVVCAGAFLFGAKLVMYTLITMYIISFTMDIGKDCFDRKKSILLISNKYDEI
                     SKVIMNKMGRGVTFLEAEGAYTQNKKKMIYCIISANEIGKFKDLIYDMDSEAFISVNN
                     VEEVKGGGFKDKFL"
     gene            complement(9005..12112)
                     /locus_tag="KRO40_002477"
     CDS             complement(9005..12112)
                     /locus_tag="KRO40_002477"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HBH2093294.1"
                     /translation="MAKFKPLVDSSVKQAEAQVFDYWKDINILEKTLEKGKDDPSFVF
                     YEGPPTANGNPGVHHVLSRTLKDSVCRYKTMSGYQVKRKAGWDTHGLPVEIQVEKELG
                     LTSKQQIEEYGIAEFNQKCRESVFSFEKQWRIMTERMAYEVDLDNPYITLDNNYIESV
                     WWILNKFNKEGYIYEGHKILPYCPRCGTGLASHEVAQGYKEVKTNTVIAKFKKKDADE
                     YFLAWTTTPWTLPSNVSLTVNADVDYLKVKKGDEVYYVSKPLADKVLGEDYEVLEEMK
                     GKDLEGLEYEQLMPFVEVDKKAFFITVGDYVTTEDGTGIVHTAPAFGEDDYNTGKRYD
                     LPVIQPVDETGKFTSTPWEGRFVMEDGLDVEIIKWLASENKLYSKEKVVHNYPHCWRC
                     QTPLVYYAKPSWYIEMTKLKDKLIENNNGVKWFPSFVGEKRFGNWLENLNDWAISRTR
                     YWGTPLPIWRCECGHTDSVGSRAELAEKAIEDVNPETVELHRPYVDDIHLKCEKCGKP
                     MTRVTEVIDCWFDSGAMPFAQHHYPFENKENFDQLFPADYISEGIDQTRGWFYSLLAV
                     STFVLGKAPYKSVLVPDLVLDKDGKKMSKSRGNTVNPMELFDQYGADALRWYLLYVSP
                     PWTPTKFDMDGLKEIQSKFIGTMKNVYNFFTLYANTDDINPTEFFVEYKDRPELDRWI
                     LSKFNNLMKDVEENLAIFELNKTLRMIQDFINDDLSNWYIRRSRRRFWATELTEDKKA
                     VYNTTYELLHGLCRAIAPFAPYMSEEMYRNLTGEVSVHLAEYPKCNEELVDTKLEEKM
                     DLAKNLVTLGRASREVERIKVRQPLQKVLVDGKFEDTISDVVDLIKEELNVKEVIFAK
                     DLDEYMNFSLKPNFKEAGPLLGSKMNLFVGALSKLNAHETANKLEKGETLTVDLDGEA
                     FEFNKDLVLIGITAKEGFNVSVENNLFVILDTKLTEELINEGYAREFISKVQQLRKSN
                     NFEVLDNIVIEYCGDDEIAKAVDHFNEYIKSETLALEINRVDDKSLEEQNLNDHMTGI
                     KVIKK"
     misc_binding    complement(12205..12437)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(12612..13139)
                     /locus_tag="KRO40_002478"
     CDS             complement(12612..13139)
                     /locus_tag="KRO40_002478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DivIVA domain-containing protein"
                     /protein_id="HBH2093295.1"
                     /translation="MLTPIEIENKEFKKGLRGYRDEEVDEFLDIIKEDYESLCRENTA
                     LKEKLGLYQDQVNKYENIEETLKATLITAQSAAEDTCSAANKKAKIIVEEADLKARQI
                     IEQANNRVIEIRKEYDALVKEFKIFRNKFKSLLEDEIRSVDEIFYDVDEKCVNAFEGT
                     TVYNYSNDEAATTLE"
     gene            complement(13174..13959)
                     /locus_tag="KRO40_002479"
     CDS             complement(13174..13959)
                     /locus_tag="KRO40_002479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HBH2093296.1"
                     /translation="MDKLKLTNHIKDIDLKNKMFKVIDKANSCIKNYDVKSTEFLNPY
                     EVKNAVAILNSTNEIKYSVDGGYEQAERSTVFIYPFYMEYEDIEDTLRFLQIEGNFKF
                     KNISHKDYLGSILGLGIKREKIGDIIIHDSFCQVVVSSDICDFIIVNLEKVSRNNVIV
                     KEISRENIVNSSSKYKEVSFTVSSDRLDCVISGIYNISRQDSAKYINGEKVHVNYEKI
                     TSTSKIVKNDDLISIRGKGRAKVTQIGDITKKGKIKVQARLIV"
     gene            complement(13969..14226)
                     /locus_tag="KRO40_002480"
     CDS             complement(13969..14226)
                     /locus_tag="KRO40_002480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HBH2093297.1"
                     /translation="MGTIRIALYYLLDIIAWMIVIKSLMTWFPNGRQSKIFDILENLT
                     EPIEGPIRSIMYKYTNGPIDFSPLIAIVLLMFLRQLVLVIF"
     gene            complement(14245..14703)
                     /locus_tag="KRO40_002481"
     CDS             complement(14245..14703)
                     /locus_tag="KRO40_002481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HBH2093298.1"
                     /translation="MSNGIISKFKNWIVDEEEDYIEDEYESGMDDIVQEEEMNSGFST
                     AKANKIVNLHTTSQMKVVIVEPKVYDEAATIADHLKQRRAVIVNLEGLTNSEVRKSIF
                     NFMNGAVYVLDGSIQKVSKSIFILAPNNVDIDANMKKELESKAFFPWQNK"
     gene            complement(14743..15447)
                     /locus_tag="KRO40_002482"
     CDS             complement(14743..15447)
                     /locus_tag="KRO40_002482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HBH2093299.1"
                     /translation="MGSIKDNLSEIRNKIDKAAKKVDRDSKEITLLAVTKTVDVDLVN
                     EAMREGITSVGENKPQELARKYDIIGDKLNWHLIGTLQTNKVKYIIDKVCMIHSLDRI
                     ALCEEIQKRAEQINREIDCLVQVNISKEESKHGLDREEVVDFVKEVSEKYKNIKIKGL
                     MTMAPFIEDEDEIRGVFKGLKDLSKQIKELNIPNVGMDVLSMGMSHDYEIAIEEGATI
                     VRVGTSIFGERNYNKK"
     gene            complement(15457..16092)
                     /locus_tag="KRO40_002483"
     CDS             complement(15457..16092)
                     /locus_tag="KRO40_002483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093300.1"
                     /translation="MKKVKYTRLVILGILIYLVFNILVMIISKNVDTLVLKNEKVDAK
                     IHVKGSIEKDANDQSNYLSTYISKEDSNNFEKNQNVIIEYHEQKLDAKVYKIYENNNK
                     IMVKLKISNQIVANQDTSVEEFDIIYNQMECLKIPKTSIKTKDNKRGVYVIDEQSQSV
                     KFVILEGITYENESSVFVDYYKNDINGVTSVNLYDKIILRPNSINTNIRIK"
     gene            16473..17513
                     /locus_tag="KRO40_002484"
     CDS             16473..17513
                     /locus_tag="KRO40_002484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2093301.1"
                     /translation="MSEILLGTGLLLLVLCCFTIFSYKAPYGMKAMGALANAACATFL
                     VEAFNLSLLGDVLGMEFFRSVGAANGSLGGVAAAILVPLALGVSPVYAVLIGLSCLDF
                     SILSGFVAGYFVSFLIKFIEKKVPPGVDLVVVILLCAPLSRLIASNVDPLVNSTLLQI
                     GQVLIEATNISPIIMGIILGGLITVVGTSPLSSMALTSIIGLTGLPMAIGALGAFGSA
                     FMNSTLFAKLKLGSKKDIISVAIEPLTQSDIISANPIPIYSTNFFGGAFSGIIVALMG
                     LVNMTPGTATPVAGFAIMFAYNPVQQVLITAGLCALFNVIAGFLGSKIFSTFKVLTAG
                     EIRGTDVEEEIA"
     gene            complement(17976..19331)
                     /locus_tag="KRO40_002485"
     CDS             complement(17976..19331)
                     /locus_tag="KRO40_002485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009170073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HBH2093302.1"
                     /translation="MNVGNILETIKMIDEEQLDIRTITMGISLLDCIDPDGDKAREKI
                     YNKIMSSAKDLVKVGKDIEREFGIPIVNKRVSVTPISIIAGATDENDYVKFAQTLDKA
                     AEDLGIDFIGGFSALVQKGYTKGDKILIKSIPKALASTNKVCASVNVGSTRCGINMDA
                     VKEMGEIIKETAELTKDAKGFGCAKLVVFCNAVEDNPFMAGAFHGVGEADRIINVGVS
                     GPGVVKRALEKVKGEPFDVVSETVKKTAFKITRVGQLVAKEASSRLDVPFGIIDLSLA
                     PTPAIGDSVANILEEMGLEVVGTHGTTAALALLNDAVKKGGVMACSHVGGLSGAFIPV
                     SEDAGMIDAVIKGALSIDKLEAMTAICSVGLDMIAVPGNTTAGTLGAMIADEAAIGMI
                     NNKTTAVRIIPAPGCDVGDMVEFGGLLGRAPVMPINTNSSELFTQRGGRIPAPIHSFK
                     N"
     gene            complement(19357..19626)
                     /locus_tag="KRO40_002486"
     CDS             complement(19357..19626)
                     /locus_tag="KRO40_002486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBH2093303.1"
                     /translation="MKAILTVIGKDKPGIVAGISDELYKQNINIVDISQKILQDYFTM
                     IMIVDLEKSLNSFEKTVEDLVERGKKLSVDVKIQREEIFNSMHNL"
BASE COUNT         6351 a         3436 c         2260 g         7673 t
ORIGIN      
        1 acctatatat aaacataaat tcatttaatt atataaattt aaaaaatatt tttttgatat
       61 attattgaca attttcatta taagagttaa aattaactca taaattacat attgggtata
      121 aaatacaatg tatgttagaa gttgtttcag aaggctatgg ttttctgatt tttttatgct
      181 cagtagtgat atgcaaaaaa gacaaagttg acatcagtta acttttacct ttattctact
      241 ttccccaaag taagaataat ctaacccctt tgagatgagc aaaagctcat ctttttttat
      301 tatcaaaaga tgctgtctca aaatagagat aatcctcttt ttcattgttg aaatgattaa
      361 aatatatttt atttcataca aaaaagagtg cctcatgaac aaaagttcac tttgagactc
      421 tctctttcat atcatatacc tttttaataa ctttaaaatt tatttatcaa gtaaagatag
      481 ctaataatta gtatcttctc tctataaatc caactttttt ataaactttt ctaagagttt
      541 ttctagcttg tttttcggct ttttctgctc ccatactata tattttttct aaataatctt
      601 tattattaag aaggtcaaca tatttttctc ttataggtct taaagcttct gatactactt
      661 cagccacatc ttctttaaat atgccataac cctttccttc atacatgttt acaatctctt
      721 ctacactctt tttacttaaa ttagaatata tatcaattag atttttaata cctggttgtt
      781 catcattgta ttttacaaca cctaaagaat cagtaacact tctttttatc tttctcttta
      841 tagaatctga atcatctgct aatagtataa atgcattttc atttgaatcg gatttactca
      901 tttttttagt tggctcttgc aaactcatca ctcttgctcc accttttggg tagtatcctt
      961 ctggaactac aaaagtaggt gaaaatctat tattaaatct atttgctaaa tcacgagcta
     1021 attctaaatg ttgtttttgg tcatctccaa ctggaactag gtcagtttga tacaacaata
     1081 tgtcagcagc cataagaact ggatatgtga ataaacctgc atttagattt gcttcactct
     1141 tttgtgattt atctttgaat tgagtcattc tacttaattc acccatataa gtcatagtat
     1201 tcaataccca cataagttca acatgctctt tgacatgtga ttgtataaat atagtatttt
     1261 tttctgggtc taatccacaa gctatatatt gagcaagtaa ttctatagta ttggctctta
     1321 aaactttagg gtcttgaggt actgttattg catgcaaatc aactatacta taataacaat
     1381 cataattgtc ttgaagttca gtccagtttt ttatagctcc taaataattt cctaaagtca
     1441 ttttgcctga tggctgtgca ccactaaata taactttttt ttcactcatt tttttgtacc
     1501 tccttatata tttatattga ttttaacata tttaaaacta tgtctttaga gttattggca
     1561 gcatcatgta caaatacatc ataagtaaca tcagcacttc catctgcctt atcagacatt
     1621 gctcttatta ttacaaatgg agtattattt aaatagcata catgagctat agctccacct
     1681 tccatttctc cacaatatcc accaaaatca tttactaatt cttcttttaa ttctttagaa
     1741 tttataaatt tatctcctgt aactactctt ccttttaata ctttatgagt ctttacttct
     1801 tccacagaag atttgtaagc agcatctata agtctttcat ctgctttaaa tacagaagtc
     1861 ttcattcttg gtataactcc cttagggtct ccaaatgctg tagtgtctac atcatactgt
     1921 atagcatcag ttgatattac tatatcatta acatcaagtt tttcgtttaa agctcctgca
     1981 acacctgtat taacaatagc atcaacctta aattcgctta ttagtatctg ggcacaaaga
     2041 gcagagttaa ccttacctat gccacacttt actaacacta cattcttacc ttccaaaatt
     2101 cccttataaa attctaagct agcttttttt atagtctctc taatatccat taaatcaact
     2161 aaaatactaa cttcttcatc cattgcacct ataattccta ttacgttcat ttttcctcct
     2221 aaattttcta tattaaaaaa tccgtcctaa atcaatagga cggatatatt ttccgtggta
     2281 ccacctaaat ttatatacac tcaaaattga atatatatat cttaatatat gctataacgt
     2341 gcatacacga tatcaaatac tctgtaatat taaattacat ttcattttac tcctcaaaga
     2401 cccattcaat aaatactttt tattaagttc tcagcatcct taattctctg tgcaaaaata
     2461 tatttattta ctatttctta tctcaggatt taatttatta atttctttat tttataatat
     2521 tccttacact ataaattgtc aactatatat tataatatcc aaaagaaatt tttaaaatac
     2581 attttattta gctgttttct tttcatatct attccataac catagaccag ataatataac
     2641 tagaagacct ccaccaatca tctctatctc atatataaca ttttcagcaa atgtaggcat
     2701 aactggtgct gcagataata atatacccac tacagttaca actaaaacca tttttgctaa
     2761 acctaggcaa gtacttgttg attttgccat agtataaggt ctaatttcat ctggtctctc
     2821 ttttcttagt ttaatataag aagcatataa caatacatat gggaataatg cagttaatgc
     2881 tgtcatagtt acaagaacat tgtatatagc atcaacagaa ggcattaatg tagtcaccaa
     2941 tagtattata gtaactatta ttgcttgaag tataactgct ttagaaggta tcttgtgttc
     3001 atttacctct actaaactat ctggaaatat tcctttttta acactaccaa ataacatttt
     3061 tattggtgat gctatgtaaa gaactattgc tcctaatact gaaaaagcta taccaaaagc
     3121 tattaattga accaaccaag aaccaattcc taaagacgca caaacagcag aaagtgcatc
     3181 taatacacct ttagaagcag taatttggtc tggtggtatt atcattgtta ttgcaattga
     3241 gcctaataca tataatgaag ctactattcc agctgatatt aatattgcct tagggaagtt
     3301 cttttcaggc ttatctattt ctgttatgaa gttagcagca gtctctgctc ctgctaaacc
     3361 aaacattata gctgatatag caacaaatgc atccatatta agttttggag tcattgaagc
     3421 tattgtgtat gtagaagcta tatcatgttt tttcaacaca aatactgcta caaatgaaaa
     3481 tattataagt atagcacttg gtattgttga acctaatgca cctgtattag taaatatttt
     3541 tgtaaaactt attcctttag ttgctataag agataatgcc cagaatatta ttaaagataa
     3601 tataagtaca aacatcttat tatcagcaag ggctggattt cctattgtat aagaaacatt
     3661 tactgctaag aaagttaaaa atgaagaata ccaaaatatt ttagctgtcc agtttaacca
     3721 agaaactaaa aatccatact tttctccaaa ggcttcctta acccaatcgt aaagacctcc
     3781 atcacctttt tgatatgtag aagctaattc agcacaaatt aaagctcctg gtacaaagta
     3841 tataaatgag aataataacc acataggtat tgcacctaat cctaaaccaa agcttgatgc
     3901 tgtagattta gctatccatc ttataccata taaagctgat acattcataa ataccaaact
     3961 ccataggcct atttttttct tttccatcct aatttaattt cccctctcta ttaattattt
     4021 taaatttaat ttcaaaatta ataaaataga ttcattatta ttaaactgat atttttcaaa
     4081 atatttgcat attcaaaaac agttttaata ataaacctta aatactttga aatcaaatct
     4141 tattaaaaat gataaattta aaagttttac cactttaatt ctaatgatac taaattttta
     4201 aaattgtttc aatattattt tattataaaa ttttatttat tatttttcat tagtatataa
     4261 aaagataaaa tacataactt tatagactta atttattact tttatagaat tttcacaata
     4321 aaaagtcatt ttacttccgt atttaatgca aaagtagaga ttaaacttaa tataaaaaat
     4381 atataacaaa ttttttttat atttctagaa gaaaagtata ctcttttttg tttaataatg
     4441 ctaaaattga tttgtattga attttgatta ggaggaaatt attatgaaag ctcaaagatt
     4501 aaatgctgta cttgaacaaa tgaaaaaaga tgatatttct caaatgttag taagtgaccc
     4561 tacttctata ttttatctta caggagtact aatccatcca ggcgaaagac tattagcatt
     4621 atacttaaat ttaaatggca ataataaatt atttataaat gaattattcc cagtttcaga
     4681 agatttaggt gttgaaatgg tttggtttaa tgatactcaa aatccagtag aaataataac
     4741 tgaacatata gacaaaaatg ctactatggg tgttgataaa aactggccag ctagattctt
     4801 attaaactta atagaattag gtggaggaag taagtttgta aattcatctt atataataga
     4861 tactttaaga atgtgtaaag atgaagaaga aaaagagtta atgagaatag cttcaaaatt
     4921 aaatgacaag gctatggaac aacttaaagc tactgtttct ggtgaactta cagaaaaaca
     4981 acttgttggt aaattatcta aaatatatga agacctaggt actgatggat tttcatttga
     5041 ccctattata ggttttggac ctaatggagc taatccacat ggtgaacctg gaaatgcact
     5101 tgtgaaacca ggagatgcaa taatcttaga tataggttgt ataaaagata actattgtgc
     5161 tgatatgaca agaactgtat tctataaaga aatacctgaa aaaggtagag aaatatttga
     5221 aatagttctt gaagctaata agagagctga agctattgta aaaccaggtg ttagattctg
     5281 tgatatagat gctgctgctc gtgactacat aactgaaaag ggatatggac agtacttcac
     5341 tcatagaact ggtcactcta taggacttga agttcatgat aaaggagatg tatcttctat
     5401 aaatacagat actgtacaac caggaatgat attctctata gagccaggta tatatttacc
     5461 aggtgagttc ggagttagaa tagaagattt agtacttgtt actgaagatg gttgtgagat
     5521 attaaacaag catgacaaag aaatatgtgt agttggttaa ttctaaaatc aatttgataa
     5581 aattaaaaag ccatataaaa atgttttaaa catttttata tggctttaat ttctcaatct
     5641 attatttatt tcaatccatt atttatattg cagtatttat attgcagtta ttaagattgc
     5701 accctttgaa gtatatgtcc ccatcactga accaatttca cagattacaa catctttgta
     5761 ttttacattc ttttccataa cttcccttac cttttgagcc ttttctgggc aattagcatg
     5821 tcctataaat aaaacctttt cttctttatc tttaattttt gactctacta aagtaatcag
     5881 ctttttcaaa ctgtttcctt cacctcttgc cttatctata ggagttacaa cgccatctgc
     5941 aacttgtatt atcgccttaa aatttaaggt atttataatt tttcctgcta ttggatttat
     6001 tctaccaccc ttaatagcat tttctaaagt ttcaagtgtt ccaaaaaatg gaggattatc
     6061 tttatattta tttattattg aaacaatctc ttcaatttct tttccttctt ttattaatat
     6121 tgctgctttt aacactaatt gtcctattcc aattgaccca ctaagtgaat ctataacctc
     6181 aactttcttg ttatttcctt ccttttcaaa catatctttt gctaaaagtg cactattata
     6241 agtcccagat aatcctgaac ttatattaat cactaataca ctttcttcct gacaatggta
     6301 tgcttctaaa aatttatcag gagaaggaca tgatgttttt ggtagtactt tactctcact
     6361 catttttcta tagaaagttt cattatctat ttcctttcca gatatataac tttcttctcc
     6421 aaaagataca tttaaaccaa caacttctat gttgtatttt tctattatat catcaggtaa
     6481 gtcacatgca ctgtccacta tcaattttat tttatccata ttaacctcac tataagatat
     6541 tattttattt attcagtcgg tcgtacgacc gatttaatta ttattttata tattgaatga
     6601 aaaaaagtca atagatatag attctcgctt tattgacaat aaatatccat aagcttataa
     6661 tgttattaat ttgttataaa tatacatgga aaggtaggtt ttatgaaaac aaataatatg
     6721 aaacaggcta ttttatcatc tgcaaccaat ttaatagcca aaaatggagt tcaaaatact
     6781 agccttgctg atattgcaaa agatgtaaat ataagtaaag gtactttgta ttatcactac
     6841 gcatctaaag atgatattat atatgatatt gcggatactc atttagaagt tataactagt
     6901 gctatactaa actgtgtaaa aaatgtcaaa tcaaaaaatt ctcaaataga aatggttaac
     6961 ttaatcttag agaaaatatc tactatagaa agtcgtggta gggtacatat gtatcttatt
     7021 tgtgaggcaa ttacttcaaa taatgattta aaggaaagaa taagattaaa atatattgaa
     7081 tggagaacta ctcttaaatc tgaaattgtt gaatcactag aaaaatataa tagtagcgaa
     7141 aatgaacagg atgctgaatc attttctttt ttactcatgt caatagttga tggtttagtt
     7201 gtccaaagtt tattaaaaac agaaaaaata ccttatgaaa atatagcttc ttttttagtt
     7261 aatcattgga tttaaactta atacttagat aattaataaa agtgaactat ttaagttatc
     7321 tactttaaca gttcactttc ttatttattc tcaataattt ttacttaaaa cattcaattt
     7381 ttatttaaac cttcatggaa tcacaaaata aaaatctctt ataaatttaa aatgttttta
     7441 tttatgttca tgtgtatgca catctgaatg ttcatgacca tgtgtatgtg tatgctcatg
     7501 gctatgctca tgagtacctg aaaaaccatc atcatgatta tggtcgtgac ctacaccatt
     7561 tacatgctca tgttcatgcc catgactgtg agaatgttga tgtgaatgtt catggttatc
     7621 tcctccacag catccttctc ctccagtccc acaacaccca cttgtatgtg gattatgatg
     7681 atttcttact acaaatctct ctcttaacat aattcttata cctcctagta tattattgag
     7741 tacttcatgt accccattaa ctacagtata catctaacta ggtataatct caatacatat
     7801 ggcatttttt aacatatata attaacatat ataatcttaa agaaatttat ccttaaaacc
     7861 tccacctttt acttcttcaa cgttattgac agaaataaaa gcttcactat ccatatcata
     7921 aattaaatct ttaaatttac ctatttcatt tgcagatatt atgcaataaa tcatcttttt
     7981 cttattttgt gtatatgcac cttctgcctc caaaaaagtg actcctctac ccattttatt
     8041 cattatcact ttggatattt catcatattt atttgatatt aaaagtatag atttttttct
     8101 atcaaagcaa tcttttccta tatccatagt aaaagaaatt atatacattg taattaaagt
     8161 gtacatcacc aatttagctc caaataaaaa agctcctgca catactacaa aaaaattaat
     8221 aaataaaaat gtatttttca taggtatatc atactttctt ttcattatgg ctgctattat
     8281 atcaagtcct ccagcagtag ctcttgcttt aaaagttaac cccataccta taccagttaa
     8341 tgcaccacca taaatacact gtagcatagt atcatctatt gggaaatatt tagcaatatc
     8401 ttgtgttagc cccagtgcta gagaaaatag taacatattg acaaaactta ttagcaaaaa
     8461 tttattatca aaatactttc tagctataat aaatattggt atgttcatca agaaacttga
     8521 tattccctga ttaataccaa ataatttgta taatataaca caaattccag ctactcctcc
     8581 acttaataac ttggctggtg ctagatataa atttattcct aaggttgata gaatcatacc
     8641 caatataata agacaatatt gtaaaaatat attattatca atacttagct ttttactttc
     8701 accatacatc aaaacgcacc cctttgcata ataaataaac caccctgcat aacacacgat
     8761 aaatttacaa ataaatttat cagaagtagt ttcctaaaaa tattattcat cctcacttaa
     8821 acgtttattc attaatattc tatcacatga cataaataat ttatatgatt tatatagatt
     8881 tatttattgt aaattttgga atattaaaac attttattga atagataatt atattacata
     8941 aaaaatccct atagaaatct ataaactaat ttctataggg attttggtta actaactatt
     9001 atttttattt ttttataact tttatacctg tcatatggtc atttaagttt tgttcctcta
     9061 aagatttatc atctactctg tttatttcta aagctaaagt ttcagacttg atatattcat
     9121 taaaatggtc aacagcctta gcaatttcat catcaccaca gtattctatt actatattat
     9181 ctaatacttc aaagttatta gattttctta attgctgtac tttagatata aattctctag
     9241 cataaccttc attaatcaac tcttcagtta gcttagtatc tagtataaca aaaagattgt
     9301 tttcaacaga tacattaaat ccttccttag cagttatacc tattaatact aaatccttat
     9361 taaattcaaa agcttcacca tctaaatcaa ctgttaaagt ctcacctttt tcaagtttat
     9421 tagcagtttc atgagcattt aatttactta atgctccaac gaataaattc atcttagaac
     9481 ctaataatgg ccctgcttcc ttaaagtttg gttttaaact aaagttcata tactcatcta
     9541 aatccttagc aaatattacc tctttaacat taagctcttc ttttattaaa tcaactacat
     9601 cacttattgt atcttcaaac ttaccatcta ctaacacttt ttgtaatggt tgacgaactt
     9661 ttattctttc tacttctctt gaagctctac ctaaagtaac taagttttta gctaaatcca
     9721 ttttttcttc taatttagta tctactaact cttcattaca tttaggatat tcagctaaat
     9781 gaacagatac ttctcctgtt aagtttctat acatttcttc tgacatatat ggtgcaaatg
     9841 gagctatagc tctacaaaga ccatgtaaca attcataagt tgtattgtac actgcttttt
     9901 tatcttctgt taattcagtt gcccagaatc ttcttcttga acgtcttata taccagttag
     9961 ataaatcatc atttataaaa tcttgtatca ttcttaaagt tttatttaac tcaaatatag
    10021 ctaaattttc ttctacatct ttcattaaat tattgaactt agataatatc catctatcaa
    10081 gttctggtct atctttatat tctacaaaaa attcagttgg atttatatca tctgtgtttg
    10141 catataaagt aaagaagtta tatacattct tcatagtacc tataaattta ctttggattt
    10201 cttttaatcc atccatatca aatttagttg gagtccatgg tggagaaaca tatagtaaat
    10261 accatcttaa tgcatctgct ccatattggt caaataattc cattggattt actgtatttc
    10321 ctcttgattt actcattttc ttaccatctt tatcaagtac aaggtctgga actaaaacac
    10381 tcttatatgg tgcttttcct aatacaaatg ttgatactgc aagtaatgag tagaaccaac
    10441 ctctagtctg gtctatacct tctgatatat agtcagctgg gaacaattgg tcaaagtttt
    10501 ccttattttc aaatggatag tggtgttgag caaatggcat agccccacta tcaaaccaac
    10561 agtctataac ctctgttact cttgtcattg gttttccaca tttttcacat tttaagtgta
    10621 tatcatctac atatggtcta tgaagttcaa ctgtttctgg atttacatct tctatagctt
    10681 tttcagctaa ttcagctctt gaaccaactg aatctgtatg accacattca catctccata
    10741 taggaagtgg agttccccaa tatctagttc ttgatattgc ccagtcattt agattttcta
    10801 accagtttcc aaatctcttc tctcctacaa aacttgggaa ccattttaca ccattattat
    10861 tttctattaa tttatcttta agtttagtca tctctatata ccagcttggt tttgcatagt
    10921 atactaatgg agtttgacat ctccagcagt gtggataatt atgaactact ttttctttgc
    10981 tatataattt attttcagaa gctagccatt ttattatttc aacatctagc ccatcttcca
    11041 ttacaaatct accttcccaa ggagtagatg taaatttacc agtttcatct actggttgaa
    11101 taactggtaa atcatatctt ttacctgtgt tgtagtcatc ttcaccaaat gctggtgctg
    11161 tatgaactat accagttcca tcttcagtag ttacataatc tcctactgta ataaaaaatg
    11221 cttttttgtc aacttctaca aaaggcatta attgttcata ttctaaacct tctaggtctt
    11281 tacctttcat ttcttctaaa acttcataat cttcacctag tactttatca gctaaaggtt
    11341 tagatacata atatacctca tcaccttttt taacttttaa ataatctaca tcagcattta
    11401 ctgttaatga aacatttgat ggtaaagtcc atggagttgt tgtccatgct aagaagtatt
    11461 catcagcatc ttttttctta aatttagcta taactgtatt agtttttact tctttatatc
    11521 cttgtgcaac ctcatgacta gcaagaccag ttccacatct tgggcaataa ggaagtattt
    11581 tatgcccttc atatatatat ccttctttgt tgaatttgtt tagtatccac catacagact
    11641 ctatatagtt attatctaaa gttatatatg gattatctaa atcaacttca taagccattc
    11701 tctcagtcat tattctccat tgtttttcaa atgagaaaac tgactctcta catttttggt
    11761 taaattcagc tattccatat tcttctattt gttgcttact agtaagtcct aactctttct
    11821 ctacttgtat ttcaactggt aatccatgtg tatcccaacc agcttttctc tttacttgat
    11881 aaccagacat tgttttatat ctacaaactg aatctttaag cgttctagat aaaacatggt
    11941 gtactccagg atttccatta gctgttggag gtccttcata gaatacgaaa cttgggtcat
    12001 ctttcccttt ttctaaagtt ttttcaagta tatttatgtc tttccaataa tcaaaaactt
    12061 gtgcttctgc ttgttttaca gaactgtcta ccaatggctt aaatttcgcc atgtaaatca
    12121 ccctttccta ctaaatatta taattccaaa attttttatt ctttcacata aatttaaata
    12181 ctaaaaaact cgcccccttt aaaccaaagg gacgagttat aaatcgcgtt accaccctaa
    12241 ttctatatgt aaactaaata ctagctacat ataacactct aatagtataa cggtactaac
    12301 cggcacagct tagtagaatt taatcgttca gcctgcagct caagagtgat ttttatcttt
    12361 ataaattcat tggttctcag catacccaat tctctgtaaa attatctaaa gataaatgtc
    12421 tctatcaacg cttttaaaaa tttatctgtg tttatatgaa attctataac aaataatttg
    12481 aatagtcaat atatttttga aaaatataat aatttctatt tttcttacat ttttatccta
    12541 tttttaattt ttgttataga tttctcaaac tcacacaatt attctacata aaaaataaac
    12601 aaattacaag cttattctaa agttgtagca gcttcatcat tactataatt atacactgtt
    12661 gttccttcaa atgcgtttac acatttttca tctacatcat aaaaaatctc atcaacactt
    12721 cttatttcat cttctaacag tgatttaaat ttatttctaa atatcttaaa ttctttgact
    12781 aaagcatcat actcttttct tatctctata acacggttat tagcttgttc tataatttgt
    12841 ctagctttta aatcagcttc ttcaacaatt atcttagcct ttttattagc cgcgctacaa
    12901 gtgtcttctg ctgcactttg agcagttatt aaagtagctt ttagtgtttc ttcaatattt
    12961 tcatacttgt ttacttggtc ttgatataac cctaattttt ctttaagagc tgtattttcc
    13021 ctacatagag attcataatc ttccttgatg atatctaaaa attcatcaac ctcttcatct
    13081 ctataccctc ttaaaccttt tttaaactct ttattttcta tctcaattgg agttagcatt
    13141 acatttcctc ccagctataa tttaaattag tccttataca attaatcttg cttgaacttt
    13201 tatttttcct tttttagtaa tatctcctat ttgtgttacc ttagctcttc ctttgcctct
    13261 aatagaaatc aaatcatcgt tttttactat tttagaagtt gaagttatct tttcataatt
    13321 gacatggact ttttctccat ttatgtattt tgcactatct tgtctagata tattgtaaat
    13381 accacttatc acacaatcta acctatctga agatactgta aatgatactt ctttatattt
    13441 tgaagaacta ttaacaatat tttctctgga aatttccttt acaattacat tatttcttga
    13501 aaccttttct aagtttacaa ttataaaatc gcaaatatca ctacttacaa ctacttgaca
    13561 aaagctatca tgtataatta tatctccaat tttttctctt tttataccta gacccagtat
    13621 tgaccctaag taatctttat gagatatatt tttaaatttg aaattccctt ctatttgtaa
    13681 aaatctaaga gtatcttcta tatcttcata ttccatgtaa aatggataaa taaatacagt
    13741 gcttctttca gcttgttcat aacctccatc cacactgtat tttatttcat ttgtagaatt
    13801 taatattgct acagcatttt tcacttcata tggattaaga aactccgtag acttaacatc
    13861 atagtttttt atacaactat tagccttgtc tatcacttta aacattttat ttttcaagtc
    13921 tatatccttt atgtgatttg ttagttttaa tttatccatc ctatcacctt agaatataac
    13981 caatactaat tgtcttagga acatcaataa tactattgca attaaaggag aaaaatctat
    14041 aggtccattt gtatatttat acattataga ccttattggc ccttctattg gctctgtaag
    14101 attttccaaa atatcaaaaa ttttactttg tcttccattt ggaaaccaag tcatcaagct
    14161 ttttataact atcatccatg ctattatatc taaaagataa taaagtgcaa ttcttattgt
    14221 tcccatatat taaccgcctt tttactattt attttgccaa gggaagaatg ctttactttc
    14281 taattctttt ttcatatttg catctatatc cacattatta ggagctagta taaatattga
    14341 tttagaaacc ttttgtatac ttccatctaa gacataaact gccccattca taaagttaaa
    14401 tatagatttg cgaacttcag aattagtcaa tccttccaaa ttcactataa ctgcccttct
    14461 ttgttttaga tggtctgcta tagttgcagc ttcatcataa accttaggtt caactattac
    14521 aactttcatt tggctagttg tatgtaaatt tacaatttta tttgcttttg cagtactaaa
    14581 gccactgttc atttcttctt cttgaactat atcgtccatg ccactttcat attcatcttc
    14641 aatgtaatct tcttcttcat caactatcca attcttaaat ttagatatta ttccatttga
    14701 cattattaac ttcctcctta aaatttattc aaatttgagt aattattttt tattgtagtt
    14761 tctttctcca aagattgatg ttccaactct aacaatggta gccccttcct ctatagcaat
    14821 ttcataatcg tgactcattc ccattgacaa aacatccatc cctacattag ggatgtttag
    14881 ttcttttatt tgttttgata aatctttaag acctttaaat acacctctta tctcatcttc
    14941 atcttctata aaaggtgcca ttgtcattag accctttatt tttatatttt tatatttttc
    15001 tgacacttct ttgacaaagt ctacaacttc ttctctatca agtccatgct tagactcttc
    15061 tttagatata ttcacttgta ctaagcaatc tatttctctg tttatttgtt ctgcacgttt
    15121 ttgaatttct tcgcataatg caattctatc taaagagtgt atcatacaaa ctttatcgat
    15181 tatgtactta actttattgg tttgcaaagt tcctatcagg tgccagttta atttatcacc
    15241 tataatatca tactttctag ctaattcttg gggtttattt tcaccaacag aagtgattcc
    15301 ttccctcatt gcctcattaa ctaagtctac atcaacagtc tttgtgactg ccaaaagggt
    15361 aatctctttg ctgtctctat ctactttttt tgcagcttta tcaattttgt ttcttatctc
    15421 agacaaatta tctttaatag aacccattat tatcacctac tttatcctta tatttgtgtt
    15481 tatactgtta ggtcttaaaa ttattttgtc atatagatta acacttgtaa ctccatttat
    15541 gtcattttta taataatcca caaatacaga agattcattc tcataagtta ttccttctaa
    15601 tatgacaaat tttacacttt gtgattgttc atcaattaca tatacaccac gtttattgtc
    15661 ttttgttttt atagaagttt taggtatttt taaacattcc atctgattat atattatatc
    15721 aaattcttcg acacttgtat cctgatttgc aacaatttgg ttacttattt ttaattttac
    15781 cattatttta ttattatttt catatatttt gtaaactttt gcatctaatt tttgctcatg
    15841 atattcaatt attacatttt gatttttttc aaagttatta gaatcttctt tactgatgta
    15901 tgtagataga taattactct ggtcattggc atctttttct atacttcctt ttacatgaat
    15961 ctttgcatca actttttcat tttttaacac caacgtatct acatttttgc taattatcat
    16021 tactaatata ttaaatacta aatatataag aataccaagt atcactaatc tggtatattt
    16081 tacctttttc aaagactctc cccctataaa attactttca ttataagtac ttcttctaaa
    16141 aaatgtttat tcctttttta taagctaata ttttacgttc taataattat tttttccata
    16201 ttaaatttat tttttatcaa tcttcctata caagactgca ttatttatat ataattgtat
    16261 tataaagtat aagtttaatt tacattttat acgttaagct tactttatat gtttttatag
    16321 ttatttttat ttttagatgc aatataaaac caattaagat ttaaaataac ttttgttatg
    16381 ttgacattta tttaggtaat catttatgaa ttaggataac gttatcataa caaaagttta
    16441 tgtcctaaaa aaaatacaag gaggattttc ttatgtcaga aattttatta ggaacaggtt
    16501 tacttttatt ggttctatgt tgtttcacaa tttttagtta caaggcccca tatggtatga
    16561 aggctatggg agctctagca aacgctgcat gtgctacttt cttagtagag gcattcaacc
    16621 tttctttact tggtgatgtt ttaggtatgg aattttttag aagtgttgga gctgctaatg
    16681 gtagtcttgg tggagttgct gctgctatac ttgtgccttt agccttaggt gtatctccag
    16741 tttatgcagt tttaatagga ttatcttgtt tagatttttc tatattatct ggattcgttg
    16801 ctggatactt tgtttctttc ttaattaagt ttatagagaa aaaagtgcca cctggagtgg
    16861 atttagtggt tgtaattctt ctatgtgcac cgctatctcg tcttatagca tcaaatgtag
    16921 acccattagt taatagtaca ctactacaaa ttggacaagt tttgatagaa gctaccaaca
    16981 ttagccctat aataatggga attatactag gaggtctaat aacagtagtt ggaacgtctc
    17041 cacttagttc aatggctctt acatctataa ttggtcttac tggtcttcct atggcaatag
    17101 gagcattagg tgcttttggt tcagctttta tgaactcaac actatttgca aaattgaaat
    17161 taggttctaa aaaagatatt atatctgttg ctattgaacc attaacccaa tcagacataa
    17221 tttcagctaa tccaatacct atatattcta ctaatttctt tggaggagcc ttttctggta
    17281 tcattgtagc cttgatgggt cttgtaaaca tgacaccagg tacagctaca cctgtggctg
    17341 gttttgctat aatgtttgct tataatccag ttcaacaagt tcttataaca gctggtttat
    17401 gtgctttatt caatgtaatt gcaggatttt taggttcaaa aatattcagt acctttaaag
    17461 ttcttactgc tggtgaaata cgtggtactg atgtagaaga agaaattgct taaaaaacaa
    17521 taagatttat aaatttatat ctcaagtagt agagttttat attgtaggca attttattaa
    17581 ttgcaaacgt tttatttttt atttatgttt atgattatta tgtgtgttga atatttagat
    17641 aaatttttat ttattatttt tatttagatt tttgtttagt tttttatttg gttgatatat
    17701 taggaataaa aattagtata gtttattact agttaagtag cataactttt tagatacata
    17761 aaaaatttta tattaattag atattattaa aataaaagcg atacatgaat ttttaaatgt
    17821 ccatgtatcg ctttattttt gccataatct taacaactga tttttaaagt ttattatctt
    17881 aacaaagttc attatcttat ataatattta aatgcatagg cttctttaat ttaaccatct
    17941 aaatatttaa ttaaatatta ttatatgtaa tataactaat ttttaaatga atgtatagga
    18001 gctggaatcc ttcctcctct ttgagtaaat aattcagatg aatttgtatt tataggcatt
    18061 actggtgctc gtcctaaaag tcctccaaat tctaccatat cacctacatc acatcctggg
    18121 gctggtataa ttctaacggc tgtagtctta ttattaatca tacctattgc tgcctcatca
    18181 gctatcatgg ctccaagcgt acctgctgta gtatttcctg gcacagctat catatcaaga
    18241 cctacagaac aaatagcagt cattgcttca agcttatcta tacttaaagc acctttaata
    18301 acagcatcaa tcatacctgc atcttcagat actggtataa acgctccact aagtcctcca
    18361 acatgtgaac atgccattac tccacctttt ttaacagcat catttaaaag tgctaatgct
    18421 gctgtagtcc catgagtacc aacaacttca agacccattt cctctaatat atttgctacc
    18481 gaatcaccaa tagcaggtgt aggagctagt gataagtcta ttatcccaaa tggaacatcc
    18541 aatctactag aagcttcctt tgccacaagt tgtccaactc ttgtaatttt aaatgcagtc
    18601 tttttaactg tttctgaaac aacatcaaaa ggctctccct ttactttctc taaagctctc
    18661 ttaacaacac cagggccact tacaccaaca tttataattc tatcagcctc accaacacca
    18721 tggaaagctc ctgccataaa tggattatct tctactgcat tacaaaatac tactaatttt
    18781 gcacaaccaa aaccttttgc atcttttgtt aattctgcag tttcttttat gatttctccc
    18841 atttctttca ctgcatccat atttatacca catcttgtag aacctacatt tactgaagca
    18901 catactttat tagtacttgc tagagctttt ggaattgact taattagtat cttatcacct
    18961 tttgtatatc ccttttgaac taatgctgag aatccaccaa taaaatctat acctaaatcc
    19021 tctgcagcct tatccaatgt ctgtgcaaac tttacatagt cattttcatc tgttgcacct
    19081 gcaataatgg aaattggagt tactgatacc cttttattta caattgggat accaaattca
    19141 cgctctatat cttttccaac cttcaccaaa tctttagcag aactcataat cttattgtat
    19201 attttttctc tagctttatc tccatcaggg tctatacaat ctaataaaga aatccccata
    19261 gttatagttc ttatatccaa ctgttcttca tctatcatct ttattgtttc aagtatattt
    19321 cctacattca ctattatcac ctccccttac tgtctactac agattatgca ttgaattaaa
    19381 tatttcttct cgctgaattt ttacatccac tgataatttc ttacctcttt caaccaagtc
    19441 ctcaaccgtt ttctcaaaag aatttaatga tttctctaaa tcaactatca taatcatagt
    19501 aaaataatcc tgtaatattt tttgtgatat atctactatg ttgatatttt gcttgtataa
    19561 ttcatcacta attcctgcca ctatacctgg tttatccttt ccaattactg ttaaaattgc
    19621 tttcataata atatcctccc ttattttttt ataaatctta tatttttaca aattgaacta
    19681 tgtgttaaca tatatttcat ttatttgtta gtaaaccact
//
LOCUS       DAEQCW010000072        19085 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.072, whole genome shotgun sequence.
ACCESSION   DAEQCW010000072 DAEQCW010000000
VERSION     DAEQCW010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19085)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19085)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19085
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.072"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(176..2146)
                     /gene="ftsH"
                     /locus_tag="KRO40_002487"
     CDS             complement(176..2146)
                     /gene="ftsH"
                     /locus_tag="KRO40_002487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBH2093304.1"
                     /translation="MNKLLKGAGFYLLVFIIIVGIVQFSGKPTEKIKDLKFSEVYREL
                     TDENISRLYFVNQTSVEGTIKDTNTKFKSYVPTEVMGNKLADEVLDQAKAGKLTFGGE
                     AKPSTPWFVEMLPTLLLIFFMVIIWFVFMNQSQGGGGKVMSFGKSKAKVHKDDEKTRV
                     TFKDVAGLDEEKEDLQEVVDFLKNPKKYIELGARIPKGMLMVGPPGTGKTYLSRAVAG
                     EAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKSAPAIIFIDEIDAVGRKRGAGLG
                     GGHDEREQTLNQLLVEMDGFGVNQGIIIMAATNRPDILDPALLRPGRFDRQVVVGTPD
                     VKGREAIFKVHSRNKPLSDDVKMDVLARRTPGFTPADIENLMNEAAILTARKREKKIK
                     METIEEAITKVIAGVAKKSKVISEKERRLTAYHEGGHAVCAHVLEEVSPVHQVTIVPR
                     GRAGGFTMQLPVEDKFYATKNEMKENIVVLLGGRVAEELVLKDVSTGASNDLERVTAT
                     ARSMVTKYGMSSKLGPMSFDSDDEVFLGNSFSSKRNYSEEVAFEIDQETKRIVDGAYD
                     KTRSILQENMDRLEYVAQALLIYETLDAEQFVKAFNKELPLNEIENAVTEENSSKEVE
                     EQLTIKLEKDEEERNNVIDINKNLEDKSDKDK"
     gene            complement(2180..3568)
                     /gene="tilS"
                     /locus_tag="KRO40_002488"
     CDS             complement(2180..3568)
                     /gene="tilS"
                     /locus_tag="KRO40_002488"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HBH2093305.1"
                     /translation="MIFDKVLSTINKHNLIQKGDKIVLGLSGGPDSVCLLHVLNRLKK
                     DFNIEIYAAHLNHQIRGIEAQKDALYVSKLCEDMGIIFFVKSINVPKYCENEGLSLEE
                     GARKLRYEMFYEIKDKIKANKIAIGHNLNDQAETVMMRIMRGTGLKGLKGIDYIRDNC
                     IIRPILDVERNEIEEYCEAYNLNPRIDKTNLENIYTRNKIRLDLLPYMKDNFNSNVIE
                     SIVRMSNSLKSDNDYIEKEAEAKFREVSNIKEKGFVEINLDDFVCLHDAIKVRVLRNS
                     IKHILGDTNFVDQRHIEDIMSLEDNSKVNKMLTLPRNIFVYRKKDSIILTNEEIVNEE
                     IEFYYNVPSNGFIKIKELKQIIETQVMSIDRYKSMKLDNSSKGFDFNKVKGGIVIRSR
                     RQGDKIKLAMGSKKVKDLFIDLKIPREERCKIPIITDSEGIICVGDYKISENYKIDEN
                     TKEVLKINFNKL"
     gene            complement(3751..4179)
                     /locus_tag="KRO40_002489"
     CDS             complement(3751..4179)
                     /locus_tag="KRO40_002489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HBH2093306.1"
                     /translation="MEEKSLSVKISINTRQYDEKGNMDTIEMTAFGKIFYKNDGIYVI
                     YKEKEEDIEITNTIKILKNQVSIKKFGAINSTMLFKCGESSTTKYVTPQGTLLIDIDT
                     RELDINIQEGEHIKLKIDYNIKVQDLFLGRNKIDIYIGTK"
     gene            complement(4196..5002)
                     /locus_tag="KRO40_002490"
     CDS             complement(4196..5002)
                     /locus_tag="KRO40_002490"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HBH2093307.1"
                     /translation="MNNKPIGVFDSGLGGLTVLKEIMKILPNEDIIYFGDTARIPYGS
                     RSKETIIKYTFQAINFLKTKGVKAIVIACNTATARSLKEAQEKYDIPIIGVIEAGART
                     AVSSTKNKIVGIIGTEGTISSKAYNLEISKIDESIEIVNKACPLFVPIVEEGWANTEV
                     AKLTAKIYLQELKEKNIDSLVLGCTHYPILKRTIGEEVGEHIKLVNPAKETAKDLKKI
                     LEVQNIINNTEIHGTYQYYVSDIPEKFSDIAREFLKKKIDKIQKVEIQKY"
     gene            complement(5204..5689)
                     /locus_tag="KRO40_002491"
     CDS             complement(5204..5689)
                     /locus_tag="KRO40_002491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase"
                     /protein_id="HBH2093308.1"
                     /translation="MATLLALTFIFMPIKEVFAYEPTENIKKVNKQEKNIAKKEVINL
                     SDNDLMLLSKLVAGEARGESYEGQVAVAAVVINRVLDPRFPDTIEEVIYQKNAFSVVL
                     DGSIKMAPTDSARKAAQEALYGTDPTNKAVYFWNPEIATCKWINRLNPYMRIGNHVFA
                     K"
     gene            complement(5740..6399)
                     /gene="spoIIR"
                     /locus_tag="KRO40_002492"
     CDS             complement(5740..6399)
                     /gene="spoIIR"
                     /locus_tag="KRO40_002492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein R"
                     /protein_id="HBH2093309.1"
                     /translation="MRKIKIRLGLLILSLISVISIMTIVINGEVKKVDNISKDYKDKL
                     IRFHVIANSNTDEDQELKLKVRDEVIKYLQPKLQNSKSIKESEAIIKKEYSSLEEISK
                     NIILKNGYNYSVKVGIQYSNFPTKQYSNIVLPAGEYKALKIIIGKGEGKNWWCVMFPP
                     LCFVDESNGVIDKSTDDKLKEVLTDKEYKLIKQDTPKKTSRVKIKFKVLEVVKDLEKK
                     F"
     gene            complement(6544..7224)
                     /locus_tag="KRO40_002493"
     CDS             complement(6544..7224)
                     /locus_tag="KRO40_002493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093310.1"
                     /translation="MENLTKLNLDNYKPLRDVVFENLREAILEGKLKPGQRLMEVQLA
                     EQLGVSRTPVREAIRKLELEGLVVMLPRKGAYVANMSLKDIMDVLEVRASLEGLAAYL
                     AAERISDEDIKKLKDISEEFKKSTLESDVDALLKLDVEFHECIFKATNNKKLIQLINS
                     LWEQVYRFRVTYMSAYDTSHNIVEEHKYLLDAIIKGDSELSKKYATEHIEKAEQFMID
                     KAMISKDL"
     gene            complement(7208..8098)
                     /locus_tag="KRO40_002494"
     CDS             complement(7208..8098)
                     /locus_tag="KRO40_002494"
                     /EC_number="2.7.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-(cytidine
                     5'-diphospho)-2-C-methyl-D-erythritol kinase"
                     /protein_id="HBH2093311.1"
                     /translation="MDFIRLKSRAKINLSIDVLGKRQDGYHFVEMIMQTIDLYDIVKI
                     KELDEDEIKVKSTSLDIPLDEDNIVYKAAKILKNKFYIKKGVEIFIEKNIPVAAGMAG
                     GSSNAAAVLVGLNHLWELRLSEDELKEIGLNLGADVPFCISGRPALAQGIGEKLTKIK
                     GLPCDTNILICKPDLFVSTKEVYQGLDLNNIKKRPNNKYLIECLKSEDIKAVSESMVN
                     ILENVTIGKHKEISDIKQVMMKNNALGSMMSGSGPTVFGLFKNKEDALIGKKELLKKY
                     KQVYVVNSSQKGVEICGEFN"
     gene            complement(8216..9766)
                     /locus_tag="KRO40_002495"
     CDS             complement(8216..9766)
                     /locus_tag="KRO40_002495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3794 domain-containing protein"
                     /protein_id="HBH2093312.1"
                     /translation="MELIKDVIKVDNRIDFGKFQTFIEAEAVVPDKKLDVYEIVKTEG
                     YISLKKIEMADGKILCRGSFNYNVIYIADDKNTISNVDGKVDINEVIEKDNVVQDMEY
                     MLFSEVEHMDCTIMNERKIKVGALMNIRGSLFEKQRLDIVKDVAQVEGIQKHRKEICF
                     QDIVGIEKAESSIRDTITINTEEIQSIISLNPCVKVKESRVTDNKVIIGGVLEINPLA
                     CTYEGELVELDRVGIEFTQFVEVPGVSDGMTEEVLLSMSDFNHIFKQNSESNTGLLEI
                     DCMACCKVKVTDEVTREVLQDAYSPQKIIKFDHKPIQLNKTLRRSEETFMVREGIRND
                     NDDIQIKDIVSVCPTMSIENSYIEGNKSIIQGIIKVEILFVPVEGLKLVYKISEEIPF
                     EHDIEMDNLTDTASVFNTACIDKVEVDLNRDQIDLIIKIKRFTEALDKKAENFIIKGE
                     DQGVYDLSKAPSIIVYICKEGDTFWNIAKKYNTTENEIAELNDIKLDEPIKPGKCLIL
                     EKKVVLVD"
     gene            complement(9860..10126)
                     /locus_tag="KRO40_002496"
     CDS             complement(9860..10126)
                     /locus_tag="KRO40_002496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HBH2093313.1"
                     /translation="MATVQTLDKIRVSLERHIGKKILLKANKGRKQIITKEGILEKVY
                     PSVFVIKLDDESNGYPRVSYSYSDLLTSNVKLQVFRDQDKLQIS"
     gene            complement(10274..11134)
                     /gene="yabG"
                     /locus_tag="KRO40_002497"
     CDS             complement(10274..11134)
                     /gene="yabG"
                     /locus_tag="KRO40_002497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation peptidase YabG"
                     /protein_id="HBH2093314.1"
                     /translation="MKVGDIVARKSHNKDIVFKIVSFGVDENNEKIAILKGIAFRVIA
                     DAYIDDLELVKAPDIKDILIDKNVENLLYKSVRKAKERQKRMTRAVPKLQLNPNTYGM
                     PGKVLQIDGDKEYLKICLDVYAQLGIPAVGVAVSEQNQYKEVRALLEKYNPDILVITG
                     HDAMTIKRGDIEDMSNYRNSSNFVKTVKEARKWQPNLDNLVIFAGACQSNYEKIISAG
                     ANYASSPGRIMIHALDPVFIVEKIACSRIDVVVPIDEVIEQTITGVKGIGGSETRGKF
                     RWAMPKTILH"
     gene            complement(11218..12156)
                     /locus_tag="KRO40_002498"
     CDS             complement(11218..12156)
                     /locus_tag="KRO40_002498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HBH2093315.1"
                     /translation="MKFIDLHCDTIAKLMENVETSELKSNKYSVDIDRLKKGDSLAQT
                     FALFVDTEEVKHPFDYCMSMANKFHEEMKKNSDEIALATNYEEIMKNQSEGKLTALLS
                     IEEGAVLEGKLENLKKFYDLGVRMMTISWNHVNELSFPHNKVEYREKGLTDFGREVVH
                     KMNELGMLVDVSHISDGGFYEIAKISSKPIIATHSNSRAMMNHSRNLTDDMIKVLANK
                     GGVTGINFFHLFLSDKSESKLEDMVRHIKHIVNVGGIDVVSLGSDFDGIDSKVEIEDI
                     SQMGKLYEPLKKEGFSEDDIEKIYYKNALRVIKEVL"
     gene            complement(12266..12427)
                     /locus_tag="KRO40_002499"
     CDS             complement(12266..12427)
                     /locus_tag="KRO40_002499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093316.1"
                     /translation="MFILRFADDDDNLSVKDFTSLTDLKKYISENNIDKTWHQIEEVK
                     KVIPNLKEE"
     gene            complement(12437..12934)
                     /locus_tag="KRO40_002500"
     CDS             complement(12437..12934)
                     /locus_tag="KRO40_002500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBH2093317.1"
                     /translation="MSLYTEWRNLSDNHESQEAEVKFWEEYLKVEAGIYNEILNNKMD
                     VVEGKVSELAEKFGTTNEFFMGFIDGISESLKEDIVLEEVEADKEVSIKIDWEKLYNN
                     MVTVEAHWLYNLQGWEDILPADQRKEIIKAYKKSKTIVKEAKIGRNDSCPCGSGKKYK
                     KCCGK"
     gene            complement(13049..13759)
                     /locus_tag="KRO40_002501"
     CDS             complement(13049..13759)
                     /locus_tag="KRO40_002501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0489 family protein"
                     /protein_id="HBH2093318.1"
                     /translation="MENYEYSGFYIEKPVGNNVFSYDKRENKSIYVPKLINGTLNDVR
                     LGNEVVFNEVDENKEIKAKGLENMVEYVLGNKKIYVFDNHNHAFYFWAKSLLKGEFTK
                     GCKLVHVDQHKDTREPENYDVDVNNLKDVFRYTNEVLNVGSFIKPALKYNIFSELIII
                     DSLYGFDLEVESEFVLDIDLDIFSSDMDYIPFELKFYKIKNLIKKAKVITIATSPYFI
                     NQEYAIKVLKELFNYDII"
     gene            complement(13935..14465)
                     /locus_tag="KRO40_002502"
     CDS             complement(13935..14465)
                     /locus_tag="KRO40_002502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093319.1"
                     /translation="MDIRALPIRITKEEAIEIAKSGKNSLFSKLILKNKYAHEVRLHY
                     IEFKIITLKIHKTKSIFKNRRYSNYINELKILVNGSTGSGSIVQDFPTYEVVKNVDCN
                     IVQYSDKDERRVKAKANKMAMRLTHRFMGGIPEIEIVKIESIFRPYWVVFFGKVELNR
                     RVSYLPIEADGFVIGM"
     gene            complement(14482..14712)
                     /locus_tag="KRO40_002503"
     CDS             complement(14482..14712)
                     /locus_tag="KRO40_002503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093320.1"
                     /translation="MSKLVSKVKKDLEIKWLGIDGFLVLLYFLITGFIFYGILTRNDI
                     IVGKIIPYGVMSVVIVIFFDYIYRVLKMTRKK"
     gene            complement(14727..16121)
                     /locus_tag="KRO40_002504"
     CDS             complement(14727..16121)
                     /locus_tag="KRO40_002504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBH2093321.1"
                     /translation="MLTFWENGIIVIFAFILLGIGYYFSRNVKDMESYYLGNRSLPWS
                     LIVGTLVASWYGGVGTVGSVEYAAIYGISAWAVWSIAAHIGRMPLALWVGPRIHIRTN
                     ITVPDLLESFYGKHVAIIGAILMFIYCAQLGEITAMGTIGNVAWKIDKELIGLIMVGV
                     VVVLTVLGGLMGVAITDMVLFFCMVFGLTMVMPGQFEQIGGFQGLTEALKDAPQLMHP
                     TKGMSAMKALMLIVYSFGAYSDPTFYQRFSAADSPKVGRRALLTCFSLWICFDMVLTM
                     TGLIVRATYPEMAPAAGYITLVLDTLPQGIRVIFIIGILGSIISTLDSYYLAAGATLA
                     NDIYGRITKKELSQKQLVKFTRIGVCLAAVMGLSVAFRFENVYDACIFVGSIWMGSAF
                     VPIVGGLLGNGRRTSMGGILGMIVGGVTFGYFKIFPVQSFELEPLVIAIPFSFIAWMI
                     GNRIGENLNTQNNL"
     gene            complement(16247..17500)
                     /locus_tag="KRO40_002505"
     CDS             complement(16247..17500)
                     /locus_tag="KRO40_002505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093322.1"
                     /translation="MESKNNVKRFLIIFILAFGTTAMYSLPYMKSSFYDPMQQALALS
                     HTQIGNLLSLYGLVGMVSYFIGGWFADRFSVRKLITFSLIASGILGFYFSTFPSYSMI
                     LLIFVLWGFTTILTFFSASVKVVRMQGSESEQGRIFGFYEGLSGVSGTLISFIGLYFF
                     GKFAEITVGFKYVVWLYSAASIICGILLFFLVEEKKDSGASDEGLSIKSLLKVVTMPK
                     AWLIGLIIFSTYLVFSSLTYLSPYLSEVYVMPMTLVSALSIIRTYVIKMGASPVAGVI
                     TDKVGSSIRVMFVGFILMTVSTAAYLVIPKSTGFIWIAVINMIILSVILFGFRGIYFA
                     SVSESNISLETTGAVVGFASFIGFSPDAFYYTIAGNWLDKYGQTGYTYIFILSVVCAV
                     IGIFATYALNKINKRENKGLNNKIA"
     gene            complement(17551..18705)
                     /locus_tag="KRO40_002506"
     CDS             complement(17551..18705)
                     /locus_tag="KRO40_002506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2093323.1"
                     /translation="MSNNINQDLETKIIHWGHSADPTTGALATPICQTATFAAKTVEH
                     FEELCMTWGYVYTRECNPTLTELEAKLAMLENAESAISSTSGMGAITSTILALVKSGD
                     HIVSSDGIFSHTKLFMSELLSKFGVEVTFVDAVNPQNVKEAMRPNTKIVYIESPLNPS
                     LDLVDIKTIAEIAHENKSLAIVDSTFGTPIVQRPIDLGADLVIHSLTKFINGHGDTLG
                     GAVAGSKELIDLVRWPSLCCFTGASLPPMSAWMILRGMKTLDMRMKKHCENGLAVAEF
                     LEEEENVELVKYPALKSHPQYELCKTQMNGLGGGVVSFKLKDGINGLTRDQASRRLMN
                     SLELATIATSLGEEHTLVQMNGENLIRIAVGLESSNDIINDFKQAIEKLK"
BASE COUNT         5922 a         3625 c         1866 g         7672 t
ORIGIN      
        1 tgatttatat aattttacat tttatttaaa taattttaaa ataataaaaa aactgaaagt
       61 atcaattaaa ttaatacatg caaatataat ttgcttatta atttaatatt atactttcag
      121 ttttagtatt taatccacat cagataataa tcttaaaatg accaaggtct taaaactatt
      181 tatctttatc agatttatct tctaaatttt tatttatatc aataacattg tttctttctt
      241 cttcatcttt ttctaatttt atagttaatt gttcttcaac ttctttagaa gaattttcct
      301 ctgtaactgc attttcaatt tcattcagag gtaactcttt attaaatgct tttacaaatt
      361 gttctgcatc taaagtttca tatataagta aagcttgtgc tacatactct aatctatcca
      421 tattttcttg taatatactt cttgtcttat catatgcacc atcaactata cgctttgttt
      481 cttggtctat ctcaaaagca acttcttcag aataatttct cttacttgaa aaactattac
      541 ctaggaatac ttcatcatca ctgtcaaatg acattggacc aagtttagaa ctcattccat
      601 actttgttac catacttctt gcagtagctg taactctttc taagtcattt gaagcacctg
      661 tagatacatc cttaagtact agctcttctg ctactctacc accaagtaaa actacaatat
      721 tttctttcat ttcatttttt gtagcataga acttatcttc aacaggaagt tgcattgtaa
      781 accctccagc tcttcctctt ggaactattg taacttgatg aacaggactt acttcttcaa
      841 gtacatgggc acaaactgca tgccctcctt catggtatgc tgtaagtctt ctttctttct
      901 cacttattac tttcgatttt ttagccacac ctgctataac ctttgttata gcttcttcta
      961 tagtttccat cttaattttc ttttctcttt ttctagctgt taatattgca gcctcattca
     1021 ttaagttctc tatatcagca ggagtaaatc ctggtgttct tctagccaag acatccattt
     1081 ttacatcatc acttaatggt ttatttcttg agtgaacttt aaatatagcc tctctacctt
     1141 ttacatctgg tgtaccaaca acaacttgtc tgtcaaatct tcctggtcta agtaaagctg
     1201 ggtcaagtat atctggtcta tttgtagctg ccatgattat tataccttga tttaccccaa
     1261 atccatccat ttcaactaga agttgattaa gagtttgctc tctttcatca tgacctccac
     1321 caagacctgc acctcttttt ctaccaactg catcaatttc atctatgaat atgatagctg
     1381 gagcactttt cttagcctgt tcaaataaat ctcttactct tgaagcacca accccaacaa
     1441 acatctcaac gaaatcagaa ccacttatac tgaaaaaggg aactcctgct tctcctgcaa
     1501 ctgctcttga tagatatgtt ttaccagttc caggaggtcc taccataagc attccttttg
     1561 gtattcttgc acccaattca atatatttct taggattctt taagaaatct actacctcct
     1621 gcaaatcttc tttttcctca tctagtccag ctacatcttt aaatgtaact ctagtttttt
     1681 catcatcttt atgaacctta gcttttgatt tgccaaaact cataaccttt ccgcctccac
     1741 cttgagactg attcataaac acgaaccaaa taatcaccat gaagaatatt aacagtaatg
     1801 taggcaacat ttcgacaaac caaggtgtag atggcttagc ttcaccacca aaagttagtt
     1861 tcccagcctt agcttggtct aacacctcat ctgcaagttt atttcccatc acttctgttg
     1921 gaacatatga cttaaacttt gtatttgtat cttttatagt accttctaca gaagtttgat
     1981 ttacaaagta taatcttgat atattctcat ctgttaattc tctatatact tcagagaatt
     2041 ttaaatcttt tattttttct gtaggcttac ctgagaattg aactatacct actataatta
     2101 taaaaacaag tagataaaaa cctgcccctt ttagcaactt attcaatata gaagccctcc
     2161 tttcatacat tgctttgccc tataatttgt taaaattaat ttttaatact tcttttgtgt
     2221 tttcatcaat tttataattt tcactgattt tataatctcc aacacatatt attccttcac
     2281 tatctgtgat tataggaatt ttacatcttt cttctcttgg gatttttaaa tctatgaata
     2341 aatctttcac ttttttactt cccatagcaa gctttatctt atcaccttgc cttctgcttc
     2401 ttattactat accccctttt accttattaa aatcaaaccc tttagatgaa ttgtctaatt
     2461 tcatactctt atacctatct atgctcatta cttgggtctc aataatttgt tttaattctt
     2521 ttattttaat aaacccatta ctaggtacat tgtaataaaa ttcaatttcc tcattaacaa
     2581 tttcctcatt cgttaatatt atactgtctt tttttctata aacaaatata tttcttggaa
     2641 gagttaacat tttatttact tttgaattat cttctaaaga cattatatct tctatatgtc
     2701 tttggtcaac aaaattagta tctcctagta tatgttttat ggaatttcta agaactctaa
     2761 ctttgatagc atcatgtaag caaacaaaat cgtctaaatt tatctctaca aagccttttt
     2821 cttttatatt tgaaacttct ctaaatttag cttctgcctc tttctcaata taatcgttat
     2881 cactttttaa actattgctc atcctcacta tagattctat tacatttgaa ttaaaattat
     2941 ccttcatata tggtaaaagg tctaacctta tcttatttct agtgtatata ttttctaaat
     3001 ttgttttatc tatcctcgga tttaaattat aagcttcaca atactcctct atctcatttc
     3061 tttccacgtc taatatgggt ctaattatgc aattatctct aatataatca attcccttta
     3121 aaccttttaa acctgttcct ctcatgatac gcatcataac cgtttcggct tggtcattga
     3181 gattatgacc tattgctatt ttattggctt taatcttatc cttaatttca taaaacattt
     3241 catatcttag cttccttgct ccttcttcta atgataatcc ctcattttca caatattttg
     3301 gtacattaat agactttaca aagaatataa ttcccatatc ctcacaaagt ttagatacat
     3361 ataatgcatc tttttgagct tctatccctc ttatttgatg gtttaaatgt gctgcatata
     3421 tttctatatt aaaatctttt tttaatctat ttagtacatg caataaacaa actgaatcag
     3481 gtcctccaga aagacctaaa actattttat cgcctttttg tattaaatta tgtttattta
     3541 tagtacttag taccttatca aatatcatat ttatccctct tacacttagt tttattcact
     3601 tttaagtata ctttctataa aaaaacgcta aacccttgta tcaattttaa gaaattaaag
     3661 tttaatataa atataataat accaaataaa ttaaataaaa ggtagttttt tcactacctt
     3721 tataaaattt ctggaaaata gccatagtta ttatttagta cctatgtata tatctatttt
     3781 attcctacct aaaaataaat cttgtacctt tatattatag tctattttca attttatgtg
     3841 ttccccttct tgtatattta tatctaattc tcttgtatca atatcaatta ataaagtacc
     3901 ttgtggggtc acatactttg tagtactact ttctccacat ttaaacagca ttgttgagtt
     3961 aatagcacca aactttttga tactaacttg atttttgagt atctttatag tattagttat
     4021 ttctatatct tcttcttttt ccttgtaaat aacatatatt ccatcatttt tataaaaaat
     4081 tttaccaaag gcagtcatct ctatggtgtc catatttcct ttttcatcat attgtctagt
     4141 atttatactt atttttacac tcaacgattt ttcctccata gattcttcat ataaactagt
     4201 atttttgtat ttctactttt tgaatcttat caattttttt ctttaagaac tctcttgcta
     4261 tatctgaaaa tttttcaggt atatctgata cataatattg ataagttcca tgaatttctg
     4321 tattgtttat aatattttgc acctctaaaa tcttttttaa atcctttgca gtctctttag
     4381 ctggattaac aagttttata tgctctccaa cttcttcacc tattgttctc tttaaaatag
     4441 gataatgagt acatcctaac actaaagaat ctatattttt ttctttcaat tcttgtaaat
     4501 atatctttgc tgtcaattta gccacttctg tatttgccca tccttcttca acaataggca
     4561 caaataaagg acatgcttta ttaacaattt ctatactctc atctatttta gatatttcca
     4621 agttgtatgc ttttgaactt atagttcctt cagttcctat tattcctaca attttgtttt
     4681 ttgtagaact tacagctgtt ctagctcctg cttctataac tccaattatc ggtatatcat
     4741 atttttcttg agcttctttt aagcttcttg cagtagcagt gttacatgct ataactatag
     4801 cttttacacc ttttgttttt aaaaagttta tagcttgaaa agtatattta attatagttt
     4861 ctttggatct tgaaccatat ggtattctgg cagtatctcc aaagtatatt atatcctcat
     4921 ttggtaatat cttcattatc tcttttagaa ctgttaatcc acctaatccc gaatcaaaaa
     4981 ctcctattgg tttattgttc atctttatac aacacctact ttacattttt gtgtttaaca
     5041 acaacttatt tatcgctaaa atttatattt atattcataa ttaatatatt attacctaaa
     5101 tgattattat agtttatttt acacaaaaaa taaaggagct atcttaaatt agaaaataat
     5161 ttctacaaaa agacaactcc tttcactact taaaaattta aatttatttt gcaaacacat
     5221 gatttcctat tctcatataa ggattcaatc tatttatcca tttgcaagtg gctatttctg
     5281 gattccaaaa atatactgct ttattagttg ggtcagttcc ataaagagct tcctgagctg
     5341 ctttacgtgc tgagtctgtt ggtgccatct ttattgaacc atcaagcaca actgagaaag
     5401 catttttttg atatatgact tcttctattg tgtctggaaa tctagggtcc aatactctat
     5461 ttattactac agctgctaca gcaacctgtc cctcatagct ttctcctcta gcttctcctg
     5521 caaccaactt agataataac atcaagtcat tatcagataa atttattact tctttctttg
     5581 ctatattttt ttcttgtttg tttactttct taatattttc tgttggttca tatgcaaata
     5641 cctctttaat aggcataaat ataaaagtca aagctaatag tgtagccatc agtttactcc
     5701 acctgtccat gattaaaacc actccttaca ttcttatttt taaaattttt tctctaaatc
     5761 cttgactact tcaagtactt taaacttaat ttttactcta cttgtttttt ttggtgtatc
     5821 ttgttttatt aacttatatt ctttatcagt taaaacttcc ttcaacttat catctgtaga
     5881 tttatctatc actccattag attcatcaac aaaacatagt ggagggaaca taacacacca
     5941 ccagtttttt ccttcacctt tcccaatgat aatctttaat gctttatatt caccagctgg
     6001 aagaactata ttagaatatt gtttagtagg gaaattgcta tattgtatac ctacctttac
     6061 actgtaatta tatccatttt taagaataat atttttactt atttcttcca gactactata
     6121 ttcctttttt ataatagctt cactttcttt tatacttttt gaattttgaa gctttggctg
     6181 taaatatttt attacttcat ctctaacttt tagtttaagt tcttggtctt catctgtatt
     6241 gctgtttgct ataacatgaa atcttattaa tttatcttta taatcttttg atatattgtc
     6301 tacttttttt acctcaccat ttattactat tgtcattatt gatatgactg atataagact
     6361 taatattaat agtcccaatc taatcttaat ttttctcatt gaaaattccc cctcaagata
     6421 aatttatatc atcaattatg tccaattaaa tttaatttat tcataatatt ttttaatact
     6481 aataaaaaaa gctatcttaa aatgattaca atcattttaa aatagctttt taaaccttat
     6541 attttataag tctttactaa tcatagcctt atctatcata aactgctctg ctttttctat
     6601 atgctctgta gcatacttct tggatagctc actatcacct ttaattatag catcaagtaa
     6661 gtatttatgc tcttcaacaa tattatgtga tgtatcataa gcagacatat aggtaactct
     6721 aaatctatat acttgttccc acaatgagtt tattaattgg attaattttt tattattagt
     6781 tgctttaaat atacattcat gaaattctac atcaagtttt aataacgcat ctacatcgga
     6841 ttccaaagtg ctttttttaa attcttctga tatatcttta agctttttaa tatcttcatc
     6901 actaattctt tcagcggcaa gatatgctgc taagccttct aggcttgctc ttacttctaa
     6961 tacatccata atatccttta atgacatatt tgccacatac gcaccttttc taggcaacat
     7021 aacgactaaa ccttctaatt caagctttct tattgcctct ctcactggag tcctacttac
     7081 tcctaattgt tctgctagtt gcacttccat tagcctttga ccaggcttta attttccttc
     7141 taagattgct tctcttaaat tctcaaagac tacatctctt aatggcttgt aattatccaa
     7201 gttcagttta gttaaattct ccacaaattt caaccccttt ttgactgcta ttaacaacat
     7261 acacctgttt atattttttt aataattctt tttttccaat tagagcatct tctttatttt
     7321 taaatagtcc aaaaactgta ggaccacttc cactcatcat agaacctaaa gcattatttt
     7381 tcatcattac ttgttttata tcacttattt ctttgtgttt acctatagta acattttcaa
     7441 gaatatttac catgctttct gatacagctt ttatatcttc agattttaaa cactctatca
     7501 aatatttatt atttggtctt tttttaatat tattcaaatc taatccttga taaacttctt
     7561 tagtagaaac gaataagtct ggtttgcata tcaatatatt tgtatcacat ggtaaacctt
     7621 tgatttttgt tagcttttct ccaatacctt gagctaaggc aggtcttcct gatatacaaa
     7681 aaggaacatc tgcgcccaaa ttaagtccta tttcttttaa ttcatcttca gataatctaa
     7741 gttcccatag gtgatttaaa cctactaata ctgcggctgc attagaactt cctccagcca
     7801 tccctgctgc tacaggaata tttttttcta tgaatatttc tacacctttt tttatataaa
     7861 atttattttt aagtattttg gcagctttat aaacaatatt atcttcatct aaaggaatat
     7921 ctaaactagt gctttttacc tttatttcat cttcgtctaa ttcttttatc tttactatat
     7981 cgtataaatc tatcgtttgc attatcattt caacaaaatg ataaccgtct tgcctttttc
     8041 ccaagacatc aatggataaa tttatttttg ctctactctt tagtcttata aaatccattc
     8101 tatcctcctt gtttaaagaa taatgcatca ctaacaataa tattatacta caaaaaataa
     8161 aataataggg tattataata ccctattata cttaattact ttaaattttt taatattaat
     8221 ctactaatac gacttttttt tctaaaataa gacacttacc aggcttaatt ggttcatcaa
     8281 gttttatatc attaagttct gcaatttcat tttctgttgt attgtatttt tttgctatat
     8341 tccagaaagt atctccttct ttgcatatat atacgattat gctaggagct ttagataaat
     8401 catatacacc ttggtcttct cccttgataa taaaattttc tgctttctta tctaatgctt
     8461 cagtaaatct cttaattttg ataatcaagt ctatctggtc cctattcaaa tcaacttcga
     8521 ctttatcaat acatgctgta ttaaacacag atgctgtatc agttagatta tccatttcta
     8581 tatcatgttc aaatggaatt tcctcactaa ttttataaac caattttaaa ccttcaactg
     8641 ggacaaataa aatttcaact tttatgattc cttgtataat gcttttattt ccttcaatat
     8701 aactattttc tatagacatg gttggacaaa cgcttacaat atcttttatt tgtatatcat
     8761 cattatcatt tcttatgcct tctctaacca taaatgtttc ttcactacgt cttaaagtct
     8821 tatttaattg aataggtttg tggtcaaatt ttattatctt ttgaggcgaa tatgcatctt
     8881 gtaatacttc tcttgtaact tcatctgtaa cttttacctt acaacaagcc atacaatcta
     8941 tttctaaaag acctgtgttg ctttcactat tttgcttgaa aatatgatta aaatctgaca
     9001 tagacaacaa tacttcttca gtcataccat cactaactcc agggacttct acaaattgag
     9061 taaactcaat acctactcta tccaactcta caagttcacc ctcatatgta caagctaacg
     9121 gatttatttc taatactcca ccaataataa ctttattgtc agtcactcta ctttctttta
     9181 ctttaacaca tggatttaaa cttattatag attgaatttc ctctgtgttt attgttatag
     9241 tatctcttat agaactttct gctttttcta ttccaactat atcttgaaaa caaatttcct
     9301 ttctgtgctt ttgtatgcct tccacttgcg ccacatcttt tacaatgtct aacctttgct
     9361 tttcaaacaa acttcccctt atattcataa gagctcctac tttaatcttt ctctcattca
     9421 ttatagtaca atccatatgc tctacttctg aaaataacat gtattccata tcttgaacaa
     9481 cattgtcttt ttctattact tcgtttatat ctacttttcc gtctacatta gaaatagtat
     9541 ttttatcatc tgcaatatag attacattat aattaaaact acctctgcaa agtatcttcc
     9601 catctgccat ttcaattttt ttaagtgata tgtatccttc tgtttttaca atttcatata
     9661 catctaattt tttgtctggt acaactgcct ccgcttcaat gaatgtttga aattttccaa
     9721 agtctattct attgtcaact ttaattacat ctttaattaa ttccatagtc tacctcctta
     9781 agtattataa aaatatcaca ctatatttat atttaaggag caaaaaaaaa attacaccta
     9841 tttttaaata ggtataattt taacttattt gtaatttatc ttgatctcta aaaacttgca
     9901 actttacatt agatgttaat aaatctgagt aactataaga tactctagga tatccattac
     9961 tttcatcatc taactttata acaaacacgc ttggataaac tttttctagt ataccctctt
    10021 ttgtaataat ctgctttctt cctttattag ctttcaacaa tattttcttt cctatatgtc
    10081 tctctaagct tactcttatc ttatctagag tttgaacagt agccacaata tcaccttctt
    10141 taacgtttat atgtttacat aatatcacat ataaacattt ttgtcaaatg tttaaactaa
    10201 ttattttata tattttttgc aaaaatgtca atactatttt tgaagatata cagtataatt
    10261 atgttaattt ttgctaatgt aatattgttt ttggcattgc ccatctaaat tttcctctgg
    10321 tttcagaacc accaattccc ttaacacctg taatagtctg ctctataacc tcatcaatag
    10381 gaactactac atcaattctt gaacaagcaa ttttctccac tataaaaaca gggtctaatg
    10441 catgtatcat tatccttcca ggcgaacttg catagtttgc tcctgcactt attatttttt
    10501 cataatttga ttggcatgct cctgcgaata tgacaagatt atccaaattt ggttgccatt
    10561 tacgtgcttc ttttactgtt ttaacaaaat ttgaagagtt tctatagtta ctcatatctt
    10621 ctatatctcc tctttttatt gtcattgcat catgacctgt tattactagt atatccggat
    10681 tatatttttc tagtagtgct cttacttctt tatactgatt ttgctctgaa acagctacac
    10741 ctactgcagg tattccaagt tgagcatata catccaagca aatttttaaa tattctttat
    10801 ctccatctat ctgtagtact tttccaggca ttccatatgt gttaggattt aattgaagtt
    10861 ttggaactgc tctagtcatt cttttttgtc tttctttagc ttttcttact gacttatata
    10921 ataaattttc tacattttta tctattaata tatcttttat atcaggtgct tttactaatt
    10981 ctaggtcatc aatataagca tctgctatta ctctaaatgc aattcccttt agtatagcta
    11041 ttttctcatt attttcatct acaccaaaag agactatttt aaatactata tctttgttat
    11101 gtgactttct agctacaatg tctcctacct tcatagttaa acctccaata aatttttatc
    11161 ttagtttata ctatgttcga tataaaactt tgtttcctaa tgtcaaaaaa acatttctta
    11221 taatacttct tttatcactc ttaaagcatt tttatagtat atcttttcta tatcatcttc
    11281 actaaaccct tcttttttta gaggttcata cagtttaccc atctgagata tatcttcaat
    11341 ctcaactttt gaatctattc catcaaaatc tgaccctaga gatacaacat ctattcctcc
    11401 aacatttaca atatgtttta tgtgtctaac catatcttca agtttacttt cacttttatc
    11461 acttaaaaat aagtggaaga agtttatacc tgtaactcca cctttatttg ctaatacttt
    11521 aatcatatca tcagttaaat ttctagaatg attcatcatt gctcttgaat tagaatgtgt
    11581 agcaattatt ggtttagaag aaatctttgc aatttcataa aatccaccat ctgaaatatg
    11641 agaaacatca accaacattc ccaattcatt catcttatgt accacttctc ttccaaaatc
    11701 agtaagccct ttttctctat attctacttt attatgagga aagctcaatt cattcacatg
    11761 attccaactt attgtcatca ttctaacccc taagtcgtaa aatttcttta aattttctaa
    11821 tttaccttca agtactgcac cttcctcaat agataaaaga gctgtaagtt taccttctga
    11881 ttggtttttc ataatttctt catagttagt agctaaagct atttcatcac tatttttttt
    11941 catttcctca tgaaatttat ttgccatact catgcaataa tcaaaaggat gttttacttc
    12001 ttcagtatca acaaaaagag caaatgtttg agctaatgaa tccccctttt tcaatctgtc
    12061 tatatcaaca gaatatttat tagacttaag ttcacttgtt tctacatttt ccattaattt
    12121 tgctatagta tcacaatgta aatcaataaa tttcatattt ataccccctg tatattttat
    12181 atttatatct aaaaatagaa atagttgtcc ttatagacaa ctattgacaa ctatttttta
    12241 atattctttt taatattact taatcttatt cttcttttaa gttaggtatt acttttttaa
    12301 cttcttcaat ttgatgccat gttttatcta tattattttc actaatatat ttttttaaat
    12361 cagttaaaga tgtaaaatct ttaactgata aattgtcatc atcatctgca aatcttaaaa
    12421 taaacatgag actcccttac tttccacaac atttcttata tttttttccg cttccacatg
    12481 ggcatgaatc atttcttcct atttttgctt ctttaactat tgttttagac ttcttataag
    12541 cctttattat ttcttttctt tggtctgctg gtagtatatc ttcccaacct tgtaaattat
    12601 atagccaatg agcctcaaca gttaccatat tgttatataa tttttcccaa tctattttta
    12661 tagaaacttc tttatcagct tctacttctt ctaaaactat atcttctttt aagctttcac
    12721 ttattccatc tatgaatccc atgaaaaatt cattagtagt tccaaatttt tcagccaatt
    12781 cacttacttt accttcaaca acatccattt tattatttaa tatttcattg tatattccag
    12841 cttcaacttt caaatattct tcccagaatt ttacttctgc ttcttgactt tcatgattat
    12901 cacttaaatt tctccattca gtatataaac tcatactttt tcctcctaag tatacctata
    12961 tttttatagt ttttatagta taaaatcttt tagttagatt ggaagtttct tctttttgat
    13021 tataccatat tctatttaaa gttaactctt atattatatc ataattaaac aattctttta
    13081 atacttttat agcatactct tggtttataa aataagggct tgtcgcaatt gttattactt
    13141 tggctttttt aattaagttt tttatcttgt aaaatttgag ttcaaatggt atatagtcca
    13201 tatcacttga aaatatatcc aaatctatgt caagaacaaa ctctgattct acttctaaat
    13261 caaatccata tagactatct attattatta attctgaaaa tatgttatat tttaaagcag
    13321 gttttataaa acttcccaca tttaaaactt catttgtata tctaaataca tcttttagat
    13381 tatttacatc tacatcatag ttctcaggtt ctctagtatc cttatgttgg tctacatgca
    13441 ctaacttgca tccttttgta aactcaccct ttaacaaaga ctttgcccaa aaataaaatg
    13501 catggttatg attgtcaaac acatatatct ttttatttcc caggacatat tcgaccatat
    13561 tctccaatcc ttttgctttt atttccttat tttcatctac ttcattaaat actacctcat
    13621 tgcctaacct tacatcattt aatgtaccat ttataagttt tggaacgtat atgctcttat
    13681 tttctctttt atcatatgaa aatacattat ttcctactgg tttttctata taaaatccac
    13741 tatattcata attttccata aaactttatt tcctccattg ttatataaat atataagtta
    13801 taattttaaa aattaaaatg cacttattgt aaatcatatc atctattata gaaaacatct
    13861 tatataacta aatataatat cttctctcaa tatgtattat acaataagtg taaaatatat
    13921 ttatataaaa tatactacat tcctataaca aaaccatcag cttcaattgg aagataacta
    13981 actcttctat tcaactccac ctttccaaaa aatactaccc aatatggtct aaaaatactt
    14041 tcaattttaa ctatttcaat ctctgggatt cctcccataa acctatgagt taatctcata
    14101 gccattttat ttgcctttgc ttttactctt cgttcgtcct tatcactata ctgcacaata
    14161 ttacaatcca cattttttac aacttcatat gtaggaaaat cttgtactat actaccagaa
    14221 cctgtagaac cattcactaa aatttttaat tcatttatat aattagaata tctcctattc
    14281 ttgaaaatgg atttcgtttt gtgaatttta agtgtgataa ttttaaactc tatataatga
    14341 agtctaactt catgagcata tttgttcttt aatattagct tactaaataa agaatttttt
    14401 ccacttttag ctatctctat agcttcttct tttgtaattc ttataggtaa cgctcttata
    14461 tccataaaat cattctcttt cttatttttt tcttgtcatt tttaaaactc tatatatata
    14521 atcaaaaaat attacaatta caactgacat aactccatat ggaattattt ttccaactat
    14581 aatatcattt ctagtcaata taccataaaa tataaatcct gttattaaaa agtacaataa
    14641 tactagaaaa ccgtctattc caagccattt tatttctaaa tcttttttta ccttagacac
    14701 taatttagac atagcagttt ctccttttat agattatttt gtgtatttaa attttcacct
    14761 attctattac caatcatcca tgcaataaat gaaaaaggta tagctatcac aagaggctct
    14821 aactcaaagc tctgaactgg aaatatttta aaataaccaa aagtcactcc accaacaatc
    14881 attcctaaaa taccacccat agatgttctt cttccatttc caagaagccc acctactata
    14941 ggtacaaatg ccgaacccat ccaaatactt cctacaaata tacatgcatc atatacattt
    15001 tcaaatctaa atgctacgct aagccccata actgctgcta aacatacacc tattctagta
    15061 aactttacta attgtttctg agataactct ttttttgtaa ttcttccata tatatcattt
    15121 gctaatgtag ccccagctgc tagataatag ctatccaatg ttgatattat agaacctaaa
    15181 attcctatta taaatattac tcttattcct tgtggtaatg tatctaaaac taaagttata
    15241 tatccagcag ctggagccat ttctggataa gtagctctta ctataagtcc tgtcatagtt
    15301 aacaccatgt caaaacatat ccatagtgaa aaacaggtta ataaggctct tcttccaacc
    15361 ttaggagaat ctgctgctga aaatctttga taaaaagttg ggtctgaata agctccaaaa
    15421 gaatatacaa ttaacatcaa tgctttcata gctgacatac cctttgtagg gtgcataagc
    15481 tgtggtgcat ctttgagtgc ttctgtaaga ccttgaaacc ctcctatttg ttcaaattga
    15541 cctggcataa ccatagttaa accaaatacc atacaaaaaa acaataccat atctgtaatg
    15601 gcaactccca taagcccacc aagtactgta agtacaacga ctactcctac cattattaat
    15661 cctattaatt ctttatctat tttccatgct acgttaccta tagttcccat agcagttatt
    15721 tctccaagtt gtgcacaata tataaacatc aaaattgccc caattatagc aacatgcttg
    15781 ccataaaaac tttccagtaa atcaggaact gttatattgg ttcttatatg aatccttgga
    15841 ccaacccaca atgctaaagg cattctccca atatgtgcag ctattgacca aactgcccat
    15901 gcagatattc catatatagc cgcatactct acactaccta ctgtaccaac tcctccatac
    15961 catgatgcaa ccaaagttcc tactattaag gaccatggta aacttcgatt tcctaggtaa
    16021 taactttcca tatcttttac atttctagaa aaataataac ctattcctaa taatataaat
    16081 gcaaatataa ctataatccc attttcccaa aatgttaaca tatctaatct ccacattctt
    16141 atattttaat ttttaacttt aatatctaaa tatgaacaac tctacccatt tccataaaaa
    16201 taggtagagt tatataataa ttataagtat ttaagtaatc ttgttattaa gcaattttat
    16261 tgtttaaacc tttattttct cttttattta ttttatttaa agcataagta gcaaatatcc
    16321 ctataactgc acatactaca gataaaataa atatatatgt atatcctgtt tgtccatatt
    16381 tatctaacca attacctgca atagtgtaat aaaacgcatc tggagaaaat cctataaatg
    16441 aagcaaatcc aactactgct cctgtagttt ctaaagatat attagactct gaaacagatg
    16501 caaagtatat acctctaaat ccaaataaaa ttacacttag tattatcatg tttattacag
    16561 ctatccatat aaatcctgta ctcttaggaa taaccaagta agcagctgta cttactgtca
    16621 ttaatataaa tcctacaaac attactctta tagatgaacc aactttatct gttataacac
    16681 cagcaactgg agatgctccc atttttataa cataagttct tattattgat aaagcagaaa
    16741 ctagagtcat tggcattaca taaacttctg ataagtatgg acttaaataa gttaaacttg
    16801 agaatactaa ataagttgaa aatattataa gaccaattag ccaagccttt ggcattgtaa
    16861 ctacttttaa caatgactta atacttaatc cttcatctga tgctccacta tcttttttct
    16921 cttccactaa gaaaaataga agtataccac atattataga tgctgcagaa tataaccata
    16981 ctacatattt gaatcctact gttatttcag caaatttacc aaagaagtaa agacctataa
    17041 aagaaattaa tgtacctgat acacctgata acccttcata aaaaccaaat attcttcctt
    17101 gctctgactc acttccttgc attctaacaa ccttaacaga ggctgagaag aaagttaata
    17161 ttgttgtaaa tccccataat acaaatatta aaagtatcat actatatgat gggaatgtag
    17221 agaaataaaa tccaagtatt cctgaagcaa ttaaagaaaa agttattaat tttctaactg
    17281 agaatctatc tgcaaaccat cctcctataa aataagatac cattcctact aatccatata
    17341 aactcaataa gttccctatt tgtgtatgac ttaatgctaa agcttgttgc attgggtcat
    17401 aaaatgatga tttcatatat ggtaaactat acatagctgt tgttccaaat gccaatatga
    17461 atattatcaa aaatctttta acattatttt tgctttccat tgattctctc tccttaaaat
    17521 tttattgttt ataatctcat tcatataatt ttattttaat ttttctattg cttgtttaaa
    17581 atcatttatt atatcatttg aagattctaa tcctacagct attcttatta gattttcccc
    17641 attcatttga actaatgtat gctcttcccc taagcttgtt gctattgttg caagctctaa
    17701 agaattcatt aatcttctac tagcttggtc tcttgtcaat ccattgatac catccttaag
    17761 tttaaatgaa actacacctc cacctaaacc attcatttga gttttacaaa gctcatattg
    17821 aggatgagat tttaatgctg gatactttac caattccaca ttctcttctt cctctaaaaa
    17881 ttctgctact gctaatccat tttcacaatg ctttttcatc ctcatatcta acgttttcat
    17941 accccttaaa atcatccatg cactcattgg tggtaaagat gctcctgtaa aacaacataa
    18001 acttggccat ctaactaaat ctattaattc ttttgaacct gctactgctc cccctaaagt
    18061 atccccatgt ccatttataa acttagtaag actatgtatt actaaatctg cacctaaatc
    18121 tattggtctt tgtacaattg gtgtcccaaa agtactatca actatagcta agcttttatt
    18181 ttcatgagca atttctgcta ttgtttttat atctactaag tctaatgatg gatttaaagg
    18241 actttctata taaactattt tagtatttgg tctcattgct tcttttacat tttgtggatt
    18301 tactgcatct acaaatgtaa cttcaactcc aaatttagat aacaactcag acatgaataa
    18361 tttagtgtgt gaaaatattc catctgaact aactatatgg tcaccacttt ttaccaatgc
    18421 taatatagta gatgttattg cccccatccc tgatgtacta gatatggcac tttctgcatt
    18481 ttcaagcata gccaacttag cttctaactc tgtaagagta ggattacact ctcttgtata
    18541 cacatatccc catgtcatac acaactcttc aaaatgctct actgtctttg cagcaaatgt
    18601 tgctgtttga catattggtg tagccaatgc acctgttgtt gggtctgcac tatgtcccca
    18661 atgtattatt tttgtctcta aatcttgatt aatattgtta ctcattttga tttcctccca
    18721 ttttgactta tttatacaac gttttcccta ccaaatttca tcaatttagc ttagtcttaa
    18781 tacatttttt caagtatact tttttatttg ttataatttc taaaaatatg acacttattt
    18841 tgttttttta cagttctaat tataaactct atagtaacta tagagtcaat atgtttttga
    18901 tatttttttt acaatgttta aaatagtcag tacaaaaata ggtatatctt agaataacta
    18961 aagtcatcct aagatatacc tatttttata tcacaatata aataattaca tataagcatt
    19021 agttttttta tcataaatag atttttcaag atttatcatc ttttcataaa tatattatag
    19081 ttaaa
//
LOCUS       DAEQCW010000073        18619 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.073, whole genome shotgun sequence.
ACCESSION   DAEQCW010000073 DAEQCW010000000
VERSION     DAEQCW010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18619)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18619)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18619
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.073"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..321
                     /locus_tag="KRO40_002507"
     CDS             <1..321
                     /locus_tag="KRO40_002507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2093324.1"
                     /translation="VEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDS
                     EITQYSFCTNGSHYAGEAGIRTIGFGPSKENLAHTIDEYIELDQLFKGTEGYYGILKS
                     VYKK"
     gene            337..1920
                     /locus_tag="KRO40_002508"
     CDS             337..1920
                     /locus_tag="KRO40_002508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacylase"
                     /protein_id="HBH2093325.1"
                     /translation="MRTLIKHGLIVDGNKTPAYEGDILIENEKILKISQDLNEEADKV
                     IDAKGRVICPGFIDTHSHSDLVILVNPYNEVKIRQGITTEVLGQDGISMAPLPQEHIS
                     SWRKNLAGLDGESDEIDWKYETTENYLKMMDYNGVGLNETYLVPHGNVRMEAMGLEDR
                     PATKEEIQKMCEITERELKAGAIGLSTGLIYIPCAYSLTEEIIEMCKVVAKYDGVFVV
                     HQRSEADTILTSMEEIIEIGKQSGVKVHFSHFKVCGKANWKYIPQVIELLEKAEKEGI
                     RVSFDQYPYAAGSTMLGVVLPPWAHSGGTDKLIERLSDENERAKMKKDIANGIEGWDN
                     FIEFAGIDQIFVTSVKTEKNKDTIGKSLLEIGKMRGKDPLDATFDLLKEEENAVGMVD
                     FYGLEEHIIGFMKRDEQNVCTDGLLAGKPHPRAYGSFPKILGRYVRELNVLTIEEAVY
                     KMTKKAARSFSIKDRGELKEGYFADIVIFDKDTVSGCDDFINSMQYPTGIDYVIINGN
                     CVVEEGKYNKIKAGKVLKN"
     gene            1948..3276
                     /gene="ssnA"
                     /locus_tag="KRO40_002509"
     CDS             1948..3276
                     /gene="ssnA"
                     /locus_tag="KRO40_002509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminohydrolase SsnA"
                     /protein_id="HBH2093326.1"
                     /translation="MILVGNGRLISQDSLNPYMEDGCVVINDNLIEDIGTTEEMKVKY
                     PVHEFIDAGKKIIMPGLINSHMHIYSSFARGMAVPGKPSENFLEILNNLWWRLDKQLT
                     LEDTKYSAYATYIECIKNGVTTVYDHHASPNAIEGSLFTISDVAKDLGIRTCLCYEVS
                     DRDGGNTIQQGINENVNFIKYAQKDDTDMIKGMFGLHAAFTLSDDTLNKCASEMAGLD
                     TGYHVHVAEGLADLQYNVDKYGKRVLERFNDFGVLKEKTIAVHCIYISAEEISLLNKT
                     NTFVVHNPESNMGNAVGCSPAIELLKRGVTVGLGTDGYTSDMFESLKVANIIHKHHLK
                     DPRVGFEESQTMLFDNNRKIAKAYYKNDLGVLKKGAYADVIVVDYIPHTPLTENTIGG
                     HTIFGMSGRSVDTTIINGKVLMKDRKLINIDEESILAKSRELSQNLWNRI"
     gene            3421..4773
                     /locus_tag="KRO40_002510"
     CDS             3421..4773
                     /locus_tag="KRO40_002510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBH2093327.1"
                     /translation="MSRDKSPKIAPVDERLPVSKSWVFSLQHVLAMCAGAVAVPMMIG
                     SAARLDHASIVFLINACLFMAGIGTLIQSVGIGNIVGAKIPVIEGTSFAAVAGMTAIA
                     SSYSDSQVAIQTVFGSVIVAGLFCILLAPVFEKLIRFFPSVVTGTVVMVIGISLFPVG
                     IKWITDNKLEAVEPNSLALALAVLAITLLSFKFLKGIWNSTAILVGIVLGTLLSMAVG
                     MADFSAVNGVGWLNLNVPLKFGMPRFEPSAILSLCLIMLVLMTESVGNMIAIHEMVDK
                     EVTGKNIKRGLFGDGISTALSGIFNSFPITPFGQNTGIVGLTGIKSRFIAVYAGVILL
                     VLGFLPKFAAIIGAIPKPVLGGVGFAMFGMVMVGGVKTLSKVKFDGTKNGVIVAVSVG
                     LSMIPLTNPDFYHNFPTWVQTIFHSGITTGSLSAVLLNIFFNELGSKKEKNNKVEEAK
                     "
     gene            4965..6074
                     /locus_tag="KRO40_002511"
     CDS             4965..6074
                     /locus_tag="KRO40_002511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2093328.1"
                     /translation="MANLKVNLYGMEFLNPIMTAAGPGAKDGALCQEAAKGGAGAICT
                     KTISVLPADVPRPCMAKTNSGFLNTELWSELPKEQWIEEEYKKVKETGLPVIVSMGYS
                     AEQIAEVAPLVKPYADAVELSTHYVGTDVAPIVNALKAAKAVLDVPVFMKMSPHTDIQ
                     TIAKAVEEAGADGLVMINSFGPCMAIDVNTGYPIMGSKAGYGWLSGAPIRPLAIRCIY
                     EASQVVNIPIIGVGGITCGKDVAEMLMAGASAVQVCTEAILKGPSIYGKIAKELNEFL
                     DENGYADVNEIKGLTHKKMAARGFRTHSVAPVVDDNKCIKCKQCVTSCVYEALEVTDK
                     LNIDADKCFGCGLCVTRCPKGALSICYNQVEAMNE"
     gene            6357..7748
                     /gene="hydA"
                     /locus_tag="KRO40_002512"
     CDS             6357..7748
                     /gene="hydA"
                     /locus_tag="KRO40_002512"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBH2093329.1"
                     /translation="MGIVLKGGKVVTSEKTYCADVRIEDEKIVDIGLDISKENDEIVD
                     VSDSYVIPGGIDTHTHFDLDTGVTKTADNFETGTKAAIVGGTTTILDFATQAKGCSLK
                     DGLEEWHEKAKDKSYSDYGFHMAITDWNDSVCNEMEDMVKEGVSSFKLYMAYKGSLQV
                     DDGVIFEALRKAEEIGGIIGFHCENGDIICELVDKAKSENNLSPKYHQLTRPAIMEAE
                     ATSRLMKIAEVANSKVYVVHLSCKESLEEVLKAKQRGVDVIVETCPQYLLLNDELYDL
                     DGFESAKYVMSPPLRNKENNEILWNAILDNQIDTIGTDHCSFNYKGQKELGINDFSKI
                     PNGSPGVEHRMSLLYTYGVCKNKISINKMVEVTSTNPAKLFGMYPNKGTIEIGSDADI
                     LVLNPNKKSKIEAKKQLQNVDYTPYEGYEVDCQIEHVYLRGKEVVRDGELICNTPSGR
                     YINRRLTKGAREW"
     gene            7742..10303
                     /gene="xdh"
                     /locus_tag="KRO40_002513"
     CDS             7742..10303
                     /gene="xdh"
                     /locus_tag="KRO40_002513"
                     /EC_number="1.17.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenium-dependent xanthine dehydrogenase"
                     /protein_id="HBH2093330.1"
                     /translation="MVEFILNGEKVVAKEGKKLLDFLREDMNITSVKNGCSEGACGTC
                     MVIIDGKATKACVFKTDKLAGKNITTIEGLSERERDVFAYSFASQGAVQCGFCIPGMV
                     ISSKALIDVNNNPTEDDIKKALKGNICRCTGYVKIIKAVDLAAKIFRENIDVPKVNCK
                     GLVGENLPRVDAVGKALGYSEYVDDMRIEGMIYGSAVRSKYPRALVKKIDIEEAKAYP
                     GVVAVLTAKDIPGTIKVGHLKKDWDTLIPEGEITRYLGDGIVLVAAETREALEEAKKL
                     VKIDYEELTPLSTTADALREDAPKIHETGNILVKEHLVRGNAKEKIENSKYVVTKRYT
                     TPATEHAFLEPECAVAGPYEDDGVIIYSTDQGVFATQHECADMLGLPYEKVRVINKMV
                     GGGFGGKEDMSVQHHAALLAYHTKRFVKVQLTRKESIIVHPKRHATEMEFTTACDENG
                     YLTGMKATIISDTGAYASLGGPVLQRLCTHAAGPYNYQDIDITGTAVYTNNPPGGAFR
                     GFGVTQSCFATECNLNLLAEMVGISPWEIRYKNAIRPGQVLPNGQFADEGTAMAETLE
                     AVKEEYEKHPRAGIACAMKNSGVGVGIPDVGRCRLVIKDGKVHIRTSASCIGQGLGTV
                     MTQVVCETANLLPENIVHEVPDTHLTPDSGNTTASRQTVFTGEATKVASNKLKEALDS
                     GKTLLDLEGEEFYGEYESITDKMGCDKENPVSHVAYGYATQVVILDENGKLEKVVAAH
                     DVGRAINPISLEGQIEGGVVMGLGYALTEDYPVVNSVPTAKFGTLGLFKSTDIPEIQA
                     LIVEKNKDLLAYGAKGVGEICTVPTAPAVQNAYYVFDKEFRTELPLQNTPYSKKK"
     gene            10455..11801
                     /gene="rpoN"
                     /locus_tag="KRO40_002514"
     CDS             10455..11801
                     /gene="rpoN"
                     /locus_tag="KRO40_002514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase factor sigma-54"
                     /protein_id="HBH2093331.1"
                     /translation="MNFNNSLELTQSQKLIMTTQLKQSLSILNMSKLELEEEIKREAE
                     NNPLVEVEKSGEINWEEYIKDMDRSRRLDRTEISYNPDNEVNLENLVKYSSNLYEDLK
                     FQISLYKLTDKELEVCEYIIDSLDEDGYLRTEEKVIVDTLKIDEELFEKCLISVQQLE
                     PSGVGARSLSECLMIQMASLGIYNEILEEIVTKDLNLIANNKYKEISKKYNMSLQKCV
                     ELINIIKTLDPKPGRTCSVEKSVYIQPDVTVEKIDDEFIVYLNEKDSYQIRINSYYKD
                     ILKNSQSDESAKEFIKERLNSATGLMKNIESRKTTVLKIAEEIVKAQDEFLRKGTKYI
                     KPLKMKDIAEKLEFHESTISRGVNGKYMLTPFGVYEFRYFFSSAIETENNEMASSTSI
                     KKIIKETIKDENKKKPLSDDHISKLLKEKGINVARRTVAKYREELGIPSSSKRKEY"
     gene            12599..13621
                     /locus_tag="KRO40_002515"
     CDS             12599..13621
                     /locus_tag="KRO40_002515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH2093332.1"
                     /translation="MKNLLEIQKKLIPQAIELMERRYSILRQISLSEPIGRRTLSNVL
                     EISERIIRSETEFLKEQGLIDVAVSGMTITKEGSDLLDKLKDIMSDIMGLSKLQDRVR
                     EKLGIKRVILVPGSCDENGSLLKDVTRYGCEYFLGILKDGDIVSITGGSTMLEFSNVI
                     KTDKRYPNSTIVPARGSMGTDVEMQSNNIVASISKKLHSNCKLLHIPDELDESAMKTL
                     SQVPEIKTTLEYIKRTDILVFSIGRADVMAKRRKLPEDKVDEILSKNAVGEAFGYYFN
                     KDGEIVYKLNTVGIDLETVKQVKETIAIFAGTEKVEALLAISNMHKNMVLVTDEESAY
                     KILSLL"
     gene            13681..14688
                     /gene="gap"
                     /locus_tag="KRO40_002516"
     CDS             13681..14688
                     /gene="gap"
                     /locus_tag="KRO40_002516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBH2093333.1"
                     /translation="MVKVAINGFGRIGRLALRKMMEQQDKFEVVAINDLTDAKMLAHL
                     FKYDTAQGRFNGEIEVKEGAFVVNGKEIKVTAERNPADLPWAELGVDIVLECTGFFTS
                     KDKAEAHIQAGAKKVVISAPATGDLKTIVFNTNSDILDGSETVISGASCTTNCLAPMA
                     KVLNDKYGIEKGLMTTIHAYTNDQNTLDGPHPKGDLRRARAAAGNIVPNTTGAAKAIG
                     LVIPSLKGKLDGAAQRVPVVTGSITELVCTLGKNVTVEEINAAMKEASNESFGYTEEM
                     LVSSDIIGISYGSLFDATQTKVMEVDGKQLVKVVSWYDNEMSYTSQLIRTLGYFAQLA
                     K"
     gene            14910..16112
                     /locus_tag="KRO40_002517"
     CDS             14910..16112
                     /locus_tag="KRO40_002517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HBH2093334.1"
                     /translation="MSMLNKKTIEDIDVCGKKVLVRCDFNVPLQDGVITDENRLNGAL
                     PTIQYLISKGAKVILCSHLGKPKGEAKPELSLAPVAKRLSEMLGKEVVFAADDNVVGE
                     NAKKATEKMENGDVVLLENTRYRKEETKNEENFSKELASLAEIFVNDAFGTAHRAHCS
                     TVGAGEFLQERVCGYLIQKELKFLGEAVANPVRPFTAILGGAKVSDKLAVINELLEKV
                     DNLIIGGGMAYTFLKAQGYEVGTSLLEIDKVEYAKEMMEKAKNKGVNLLLPVDVVMAD
                     HFAPDATPIVTEDANVKEDYMGLDMGPKTIANFVKTIKESKTVVWNGPMGVFEFENFA
                     NGTLSVARAMAELTDATTVIGGGDSAAAVNQLGFGDKMTHVSTGGGASLEFLEGKELP
                     GIAALDNK"
     gene            16138..16881
                     /locus_tag="KRO40_002518"
     CDS             16138..16881
                     /locus_tag="KRO40_002518"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HBH2093335.1"
                     /translation="MRKPIIAGNWKMHKTIKEALEFVNEVKDKVNSDKVEAVICAPFT
                     LLKDLKEATKGTNIKIGAQNMHFEEKGAFTGEVSPLMLKEIDMDYVVIGHSERRQYFN
                     ETDETVNKKVLKALEVGIDPILCVGETLEQREAGKTKDVCKVQVEKALENVLKDDLAK
                     VVVAYEPIWAIGTGKTATAEDANDVISYIREVIKGLYGELANEVRIQYGGSVKPSNVA
                     EIMGQSDIDGALVGGASLASNDYLDLVNF"
     gene            16890..18422
                     /locus_tag="KRO40_002519"
     CDS             16890..18422
                     /locus_tag="KRO40_002519"
                     /EC_number="5.4.2.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003228330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-independent
                     phosphoglycerate mutase"
                     /protein_id="HBH2093336.1"
                     /translation="MMKKPVALIIMDGFGYNKDVKGNAIAESKTPNLDRIKKEYPNTL
                     INASGLDVGLPDGQMGNSEVGHTNIGAGRIVYQDLTRITKSIKDGDFFTNKVLCEAMD
                     NAKENSLHVMGLLSDGGVHSHIDHLKAIIKMAKDKGVQKVYVHAFTDGRDTDPQSALE
                     YAKEVQASMDEIGVGEFATVSGRYYAMDRDKRWERVELAYNAMVRGIGEKANSIEEAI
                     QNSYDDGKNDEFIMPTVIMKDDKPAGSIKENDSIIFFNFRPDRARQITRALVCEEFDG
                     FKREDIKNFFVCLTEYDITIENVHIAFGPQSLANTLGEYLAKNGKTQLRAAETEKYAH
                     VTFFFNGGVEEPNKGEERLLIPSPKVATYDLKPEMSAYELTDKALDKLGEDKFDFIVL
                     NFANPDMVGHTGSIEAAIKAVETVDTCVGKLIDKIVELGGSAIITADHGNAEYMLDPE
                     TGKTVTAHSINPVPFIVVGQEYESAKLLDGGRLSDIAPTVLDMMKLEKPEEMTGHSLI
                     SK"
BASE COUNT         7466 a         2149 c         3742 g         5262 t
ORIGIN      
        1 gttgaaaaag ctgattgcta tacaggaaat actatagaaa gtgaaagatt cttcccaggt
       61 tggttatatg atgaagaaga tgaatttgtt caagcagcgt ataagggatt aaaagaagct
      121 ggaatagatt cagaaataac tcaatactca ttctgtacga atggaagtca ctacgcaggt
      181 gaggctggaa taagaactat aggatttggt ccttctaagg aaaatcttgc tcatacaata
      241 gatgagtata tagaattaga ccaattattc aaaggtacag aaggatatta tggtatatta
      301 aaatcagttt ataaaaaata attaggagat ggttttgtga gaactttaat aaaacatgga
      361 cttatagtag atggaaataa aacaccagca tatgaaggag atattttaat agaaaacgag
      421 aaaatattaa aaatatcaca agatttaaac gaagaagctg acaaagttat agatgcaaaa
      481 ggtagagtta tatgtccagg tttcatagat actcatagcc attcagacct agttatttta
      541 gttaatccat ataatgaggt aaagattaga cagggaatta caacagaagt gttgggccaa
      601 gatggtatat ctatggcccc tctacctcaa gagcatatat cttcttggag aaaaaattta
      661 gcaggtttag atggtgaaag tgatgaaatt gattggaaat atgaaacaac agagaattat
      721 ttaaaaatga tggattacaa tggggtaggt ttaaatgaaa cttatttagt acctcatgga
      781 aacgttagaa tggaagctat gggacttgaa gatagacctg ctactaaaga agaaattcaa
      841 aaaatgtgtg aaatcacaga gagagaatta aaagcaggag ctataggatt gtctactgga
      901 cttatatata taccttgtgc atactcattg actgaagaaa ttatagagat gtgtaaggta
      961 gtagcaaaat atgacggagt atttgtagtt caccaaagaa gtgaagcaga tacaatttta
     1021 acttcaatgg aagaaatcat agaaattgga aaacaatcag gagtaaaagt tcatttttca
     1081 cattttaagg tttgtggtaa agcaaactgg aagtatatac cacaagttat agagctttta
     1141 gaaaaagcag aaaaggaagg aataagagta tcttttgacc aatatccata tgcagcagga
     1201 agtacaatgc ttggagtagt tttacctcct tgggcacatt ctggaggaac tgataagtta
     1261 atagaaagat taagtgatga aaacgaaaga gcaaaaatga aaaaagatat agcaaatgga
     1321 atagaaggct gggataattt tatagaattt gctggaatag accaaatatt tgtaacaagc
     1381 gtaaaaacag aaaagaataa agatacaatt ggtaagagct tattagaaat tggaaaaatg
     1441 agaggaaaag acccattaga tgcaacgttt gatttattaa aagaagaaga aaatgcagtt
     1501 gggatggtag atttctatgg attagaagaa catataatag gattcatgaa aagagacgag
     1561 caaaatgtgt gtacagatgg tcttttagca ggtaaaccac atccaagagc ttatggttct
     1621 ttccctaaaa tactaggaag atatgttaga gagttgaatg tgttaacaat cgaagaagct
     1681 gtttataaaa tgactaaaaa ggcagctaga agctttagta taaaagatag aggcgaatta
     1741 aaagaaggat attttgcaga tatagttata tttgacaagg atacagttag tggttgtgat
     1801 gattttatca actctatgca gtaccctaca ggtatagatt acgtaattat aaatggaaat
     1861 tgtgttgttg aggaaggaaa atacaataaa attaaagcag gaaaagtact taaaaattaa
     1921 atcttagctt taaggaggaa taaatttatg attttagtgg ggaatgggag gctaataagc
     1981 caagattctt taaatcccta tatggaagat ggatgtgtag taataaatga taatctaatt
     2041 gaagatatag gtactacaga agaaatgaaa gttaaatatc cagtacatga atttatagat
     2101 gcaggcaaga aaataatcat gccaggtcta ataaattcac atatgcatat atacagctca
     2161 tttgctagag gaatggcagt tccaggaaaa ccttctgaga actttttaga gatactaaac
     2221 aatttatggt ggagacttga caaacagctt acactggaag atacaaaata cagtgcatat
     2281 gcaacgtata tagaatgtat aaaaaatggt gtaacaacag tttatgacca tcatgcaagt
     2341 ccaaatgcaa ttgaaggcag tttgtttaca atatcagatg ttgcaaagga tttgggaatt
     2401 agaacgtgtc tttgttatga agtgtctgat agagatggtg gaaatacaat ccaacaaggt
     2461 atcaatgaaa acgtaaactt tataaaatac gctcaaaaag atgatacaga catgataaaa
     2521 ggaatgtttg ggcttcatgc tgcatttaca ctatctgatg atacattaaa taaatgtgct
     2581 tcagagatgg ctggtcttga tacaggttac catgtacatg ttgctgaagg actagcagac
     2641 ttacaatata atgtagataa atatggaaaa agggttttag aaagattcaa tgattttgga
     2701 gtactaaaag aaaaaacaat agcagttcat tgtatatata taagtgcaga agaaatcagt
     2761 cttttaaata aaacaaatac atttgtagtt cataatccag aatctaatat gggaaatgca
     2821 gttggatgtt ctcctgcaat agagttatta aaaaggggag ttacagtagg attaggaact
     2881 gatggatata ctagcgatat gtttgaatca ttaaaagttg ccaatataat tcacaaacat
     2941 cacttaaaag acccaagagt tggatttgaa gaatcacaaa caatgttatt tgataacaat
     3001 agaaaaatag ctaaagctta ttataaaaat gacctaggag tacttaaaaa aggtgcttat
     3061 gcagatgtta tagtagttga ttatatacca catactccat tgacagaaaa tacaataggg
     3121 ggacacacta tttttggaat gagtggaaga agcgtagata caactattat aaatggaaaa
     3181 gtacttatga aagatagaaa gttaataaac atagatgaag aaagtattct agcaaaaagt
     3241 agagaattaa gtcaaaatct atggaataga atttaaataa ttgatattaa tatacaagta
     3301 agaaacaaga atttagatgt taaaaacaga gcttaaacaa aaataggaat ttaaatgaag
     3361 tatataaata aaaaatatac ggaatagaat attaaattaa atatagaagg gagacccaaa
     3421 atgtctcgag ataaaagccc taaaatagct ccagtagatg aaaggttacc tgtatccaaa
     3481 tcttgggtat tttcactaca gcacgtttta gcaatgtgtg caggagcagt agcagttcct
     3541 atgatgatag gaagtgctgc acgactagat catgctagta ttgttttttt aataaatgct
     3601 tgcttgttta tggcaggtat aggaacactc atacaaagtg ttggtatagg aaatattgta
     3661 ggtgctaaaa taccagtaat agaaggaact agttttgccg ctgtggcagg tatgacagca
     3721 atagcctcat catatagtga ttcacaagtt gcaatacaga cagtatttgg ctctgtaata
     3781 gtagctggat tgttttgtat attacttgct ccagtatttg aaaaattaat aagatttttc
     3841 cctagtgtag ttactggaac agttgttatg gtaataggta tttcactatt tccagttggg
     3901 ataaaatgga taactgacaa caaattagaa gcggttgaac caaactcatt agcattagct
     3961 ttagcagtat tggcaataac tttactttca tttaaattct taaaaggaat ttggaatagc
     4021 acagctatat tggtaggtat agtacttggt acactacttt ccatggcagt tggaatggca
     4081 gattttagtg cagtaaatgg agttggttgg cttaacttaa atgtaccttt aaaatttgga
     4141 atgcctagat ttgaaccatc tgcaatacta tcattgtgtt tgattatgtt ggtacttatg
     4201 acggaatcag ttggtaatat gatagctatt catgaaatgg tagacaaaga agtaacaggt
     4261 aaaaatatta aaagaggtct atttggagat ggaatatcta cagcattatc tggaatattc
     4321 aattcatttc caataactcc atttggtcaa aatacaggaa tagtaggtct tacaggtata
     4381 aaatcaagat ttatagcagt ttacgcaggg gttatattgc tagtacttgg attcttacca
     4441 aaatttgcag caataatagg agcaatacct aagcctgttc ttggaggcgt aggattcgca
     4501 atgtttggaa tggtaatggt tggaggagta aaaactttaa gcaaagtaaa atttgatgga
     4561 actaaaaatg gggttatagt agcagttagt gttggtttgt ctatgatacc actaacaaat
     4621 cctgatttct atcataattt cccaacttgg gtacaaacaa tattccatag tggaataaca
     4681 acaggtagtt tatcagcagt gcttttaaac atattcttca atgaactagg ttctaaaaaa
     4741 gaaaaaaata ataaagttga agaagcaaaa taaaaataaa acaagtaaaa atctatattg
     4801 acttaaagtc attaagtatt aataaaaata attcagagat attaataatt caacaaaact
     4861 atcttatatt ttaaataata taaaaaagta aataaataac gaatacaaat aaaagaatac
     4921 aatctaaata ttaaaaatat ttaatttaag ggagagataa taatatggct aatttaaaag
     4981 ttaatttata tggaatggaa tttttaaacc caattatgac agcggcagga cctggagcaa
     5041 aagatggtgc tctctgtcaa gaggcagcaa aaggtggagc aggagctata tgtacaaaaa
     5101 ctatatctgt attaccagct gatgtaccaa gaccatgtat ggcaaaaact aatagtggtt
     5161 ttttaaacac agaattatgg tcagagcttc caaaagagca atggatagag gaagaataca
     5221 aaaaggtaaa agaaacaggg cttccagtaa tagtaagtat gggatattca gcagagcaaa
     5281 tagctgaggt tgctccttta gtaaagcctt atgcagatgc agttgaatta tctactcatt
     5341 atgtaggtac agacgttgca ccaatagtaa atgctttaaa agctgcaaaa gctgttttag
     5401 atgtaccagt atttatgaaa atgagtcctc atactgacat tcaaactatt gcaaaagctg
     5461 ttgaagaagc aggtgcagat ggacttgtaa tgataaactc atttggacca tgtatggcaa
     5521 tagatgtaaa tacaggatac cctataatgg gaagtaaagc tggatacgga tggttatcag
     5581 gtgcaccaat aagacctcta gcaataagat gtatatatga agcttctcaa gttgtaaata
     5641 taccaataat cggtgttggt ggaatcactt gtggaaaaga cgtggctgaa atgttgatgg
     5701 ctggagcaag tgctgttcaa gtatgtacag aagcaatcct taaagggcct tctatctatg
     5761 gaaaaattgc taaagaatta aatgaatttt tagatgagaa tggatatgct gatgttaatg
     5821 aaataaaagg attaactcat aagaaaatgg cagctagagg gtttagaact cattcagtag
     5881 ctccagtagt ggatgataac aagtgtatca aatgtaagca atgtgtaaca agctgtgtat
     5941 acgaagcttt agaagttaca gataagttga acatagatgc agacaagtgt tttggatgtg
     6001 gattatgtgt aactagatgt ccaaaaggag ctttaagcat ctgctacaat caagtagaag
     6061 ctatgaatga gtaataatta tatagaattt tggtaattaa cttagagtaa taggtattag
     6121 gataataaaa tatatcagat aaacaaacac atattatgca ttaataatac agtctaaagt
     6181 taataatttt attatattga tttaactaaa tattagttta gctgaatatt aatttaatta
     6241 ggtattggtt taatcttaat atagatttac tacgtataag tgaactaact agattacttt
     6301 aagttaattt tttcatataa aataaattga tacattacaa gtaaggtgga gtctatatgg
     6361 gaattgtttt aaaaggtggg aaagtagtaa caagtgaaaa aacttactgt gcagatgtaa
     6421 gaatagaaga tgaaaaaata gtcgatatag gtcttgatat atcaaaagaa aatgatgaaa
     6481 tagttgatgt tagtgattct tatgttatac caggaggtat agatacacac acacactttg
     6541 acttagatac aggcgttact aagacagcag ataactttga gacaggaaca aaagctgcta
     6601 tagtaggagg aactactact atattggatt ttgctacaca agctaaagga tgttctttga
     6661 aagacggatt agaagaatgg catgaaaaag ctaaggataa atcctattca gattatggct
     6721 ttcatatggc tataacagat tggaatgact cggtttgtaa tgaaatggag gatatggtga
     6781 aagagggagt atcttcattt aaactgtata tggcgtataa aggaagcctt caagttgatg
     6841 atggtgtaat ctttgaagca ttgagaaaag cagaagagat aggaggaatt attggtttcc
     6901 attgtgaaaa tggggacata atatgtgaac ttgtggataa agcaaagtca gaaaataatt
     6961 tatctccaaa atatcatcaa ttaactagac cagctataat ggaggcagaa gctacatcaa
     7021 gacttatgaa gatagctgaa gttgcaaatt ctaaagtata tgtagttcac ttaagctgta
     7081 aagaatcctt agaggaggtt ttaaaagcta agcaaagagg tgtggatgta atagttgaaa
     7141 cttgtcctca ataccttcta ttaaatgatg aattatatga tttagatgga tttgaaagtg
     7201 ctaagtatgt aatgtcacca cctttaagaa ataaagaaaa taatgaaata ttatggaatg
     7261 ctattttaga taatcaaata gacactatag gaacagacca ttgttctttt aattataagg
     7321 gacagaagga acttgggata aacgatttca gcaagatacc aaatggttct ccaggtgtag
     7381 aacataggat gagtctttta tacacatatg gagtctgtaa aaataaaata tctatcaaca
     7441 agatggtaga agtaacatca actaatccag caaagttgtt tggaatgtat cctaataaag
     7501 gaactataga aataggcagt gatgcagata tattagtctt aaatccaaac aaaaaatcca
     7561 aaatagaagc aaaaaaacaa ttacaaaatg tagattatac accttatgaa gggtatgaag
     7621 tggattgtca aatagaacat gtttatttaa gaggaaaaga agtagttaga gatggagaat
     7681 taatttgtaa tactccaagt gggagatata taaataggcg tctaacaaag ggggctagag
     7741 aatggtagaa tttatattaa atggagagaa agttgttgca aaagaaggca aaaaactttt
     7801 agacttcctt agagaagata tgaatataac ttcagttaaa aatggatgtt cagaaggtgc
     7861 ttgtggaaca tgtatggtta taatagatgg taaagctact aaagcatgtg tatttaaaac
     7921 tgataaatta gctgggaaaa acataacaac tatagaggga ttatcagaga gagaaagaga
     7981 tgtttttgca tattcttttg ctagtcaagg agctgtacaa tgtggatttt gtattccagg
     8041 tatggtaatt agttcaaaag cacttataga cgttaataat aatcctactg aagatgatat
     8101 aaagaaagct ttaaaaggca atatatgtag atgtacaggg tatgtaaaaa taattaaagc
     8161 tgtcgattta gcggcaaaga tttttagaga aaatatagat gtgccaaaag taaactgtaa
     8221 gggtttagta ggtgaaaatc ttcctagagt tgatgcagtt ggcaaagcac ttggatattc
     8281 tgaatatgta gatgatatga gaattgaggg tatgatttat ggttcagcag ttagatctaa
     8341 gtatcctaga gctttagtta aaaaaataga tatagaagaa gcaaaagctt atccaggagt
     8401 tgttgcagtt ctaacagcta aagatattcc aggaactata aaggtaggac acttaaagaa
     8461 ggattgggat actttaatac cagaaggtga aataactaga tacttaggag atggaatagt
     8521 tttagtagca gcagaaacta gagaagcgtt agaagaggcc aaaaagctag ttaagataga
     8581 ttatgaggaa ttaacaccat taagtactac agcagatgca cttagagaag atgctccaaa
     8641 gatacatgag acagggaata tacttgttaa ggaacattta gtaagaggaa acgctaaaga
     8701 aaagatagaa aattcaaaat atgttgtaac taaaagatat actacacctg ctacagaaca
     8761 cgcattttta gagcctgaat gtgcagtagc tggtccttat gaagatgatg gagtaataat
     8821 ctattcaaca gaccaagggg tgtttgccac tcaacatgaa tgtgcagata tgttaggatt
     8881 accatatgag aaggtaagag ttataaacaa aatggtagga ggagggtttg gtggaaaaga
     8941 agacatgagt gttcaacacc atgcagcctt acttgcatac catacaaaga gatttgtaaa
     9001 agtacagtta acaagaaaag aaagtattat tgttcatcca aaacgacatg ccacagaaat
     9061 ggaatttacg acagcatgtg atgaaaatgg atacttaacg ggtatgaagg caacgataat
     9121 atctgacaca ggtgcatatg cctctcttgg aggaccagtg ctacaaagac tgtgtactca
     9181 tgcagcagga ccatacaatt atcaagatat tgatataaca ggaacagcag tatatactaa
     9241 taaccctcct ggaggagcat ttagaggatt tggagttaca cagagttgtt ttgcaactga
     9301 atgtaatcta aatttacttg ctgaaatggt tggaatatct ccttgggaga taagatataa
     9361 aaatgcaata agacctgggc aagttttacc aaatggtcaa tttgcagatg aaggaacagc
     9421 aatggcagag acactagaag ctgtaaaaga agagtatgaa aagcatccac gtgcaggtat
     9481 agcttgtgct atgaaaaata gtggggttgg agttggtata cctgatgttg gaagatgtag
     9541 attggtgata aaagatggca aagttcacat aagaacaagt gcttcttgta taggtcaagg
     9601 gcttggtact gttatgactc aagtagtttg tgaaactgct aacctacttc ctgaaaatat
     9661 agttcatgaa gttccagata ctcatttaac accagactct ggtaatacta cggcttcaag
     9721 acagacagta tttacgggag aagctactaa ggttgcatca aataagttaa aagaagcttt
     9781 agactctggc aaaactttac ttgatttaga gggagaagag ttttatggag aatatgaaag
     9841 tattacagat aaaatgggtt gtgacaaaga aaatccagta agtcatgttg cttatggata
     9901 tgcaacacaa gttgtaattc tggatgaaaa tggaaaacta gaaaaagtag tagcagcaca
     9961 tgatgttgga agagctataa atccaatcag tttagaaggt caaatagaag gtggagtagt
    10021 tatgggtctt ggatatgctc taaccgaaga ttacccagta gtcaactctg ttcctacagc
    10081 taagtttggt acattaggtt tatttaaatc tacagatata ccagaaatac aagctttaat
    10141 agttgaaaag aacaaagatt tattggctta tggggcaaaa ggtgtaggag aaatttgtac
    10201 agttcctact gcaccagcag tacaaaatgc ctattatgta tttgataaag aatttagaac
    10261 tgagttacca ctacaaaata ctccatatag taaaaaaaag taacaaaaaa aagaaatatt
    10321 aaataaaaaa atagatgaaa ttgtaaataa aaaaaaccct tttgcataag gtatatttta
    10381 aatgatagaa tatacatata caggagggtt tttcttttat aaaataagtt taataaaatt
    10441 gagaggtgag cagaatgaat tttaataata gtctagaatt aactcagtct cagaagctaa
    10501 taatgactac acaacttaag caatcattat caatattaaa tatgagtaag ttagagttag
    10561 aagaagagat aaaaagagaa gcagagaata acccattagt tgaagtcgag aaaagtgggg
    10621 agataaattg ggaagagtat ataaaagaca tggataggtc aagacgttta gatagaacag
    10681 agataagcta taatcctgat aatgaagtta atctagaaaa tttagttaaa tattcgtcaa
    10741 atttatatga agatttaaaa tttcagataa gcctgtataa acttacagac aaagaattgg
    10801 aagtctgtga gtatataatt gatagtttag atgaggatgg atatttaaga actgaggaaa
    10861 aagtaattgt tgatacctta aagatagatg aagaactttt tgaaaaatgt ttaattagtg
    10921 ttcagcagtt ggaacctagt ggagtagggg caagaagtct ttcagaatgt ctgatgatac
    10981 aaatggctag tttaggaata tataatgaaa ttttagagga aatcgttaca aaagacttaa
    11041 atttaattgc aaataataaa tataaagaga taagtaaaaa gtacaatatg tcattacaaa
    11101 aatgtgttga actaataaac ataattaaga cattagaccc caaaccagga agaacttgtt
    11161 cagtagagaa aagtgtatac attcaacctg atgtaacagt agaaaaaatt gatgatgaat
    11221 ttattgtata tttaaatgag aaagattctt atcaaataag aatcaatagt tattataaag
    11281 acatattaaa aaattcacag tctgatgaaa gtgcaaaaga atttataaaa gaaagactaa
    11341 attcagcaac aggacttatg aaaaatatag agagtaggaa aactacagta cttaagattg
    11401 cagaagagat agtaaaagct caagatgaat ttttgagaaa agggacaaaa tatataaaac
    11461 ctttgaaaat gaaagacata gcagaaaaat tagaatttca tgaatctact ataagtagag
    11521 gtgtaaatgg taaatatatg ctaacacctt ttggcgtata tgaatttagg tactttttca
    11581 gtagcgccat tgagactgag aataatgaaa tggcatctag tacaagcata aaaaaaatta
    11641 taaaggaaac aataaaagac gaaaataaaa agaaaccttt aagtgatgac catatatcta
    11701 agttactaaa agaaaaagga atcaatgttg caagaaggac agttgccaaa tatcgtgaag
    11761 aattaggaat cccatcttca agtaagagaa aagaatacta ataagtaaaa gacaaatatc
    11821 agtatggtaa ggggaaaagg ctaattaaga gatgaatgta gattgggcta aaaattttat
    11881 aaagtaaaat aatataatat gaaaaagtat taaaatgcta taaggtatta aaaaactggg
    11941 gaacattaaa acattaagat agcaaagaac ataaaaaact aaagaagatt aaaacattaa
    12001 agaacattag agctttgagg aatattagaa ctttaaagaa tattaaaatt tataaaatat
    12061 aaaaatacta aaaagaattg aaaaactggg gaacattaaa atattgtaaa atgctaaaaa
    12121 actagaaaac ataattaaat aagtgcttat aaagaatgat taaattaaat aagtgtttgt
    12181 aaagaataat tagatattag aaaaagaaga atacctagat aaataaacta ttattaaatt
    12241 taataatcac aaaaggaaaa cacgtagggt ataaataaaa atcttaacta gataaaagta
    12301 aacttagttg tagataaaaa taactagaaa taaaagtaac tagaaataaa attatttata
    12361 gtaataaata ttagaatgaa aatataaaaa aatatatata aaaagcctta tataaaaaga
    12421 aaaaatactg tgatttgaaa atggtggaga aatattttat aaaataaaaa aataaaaaag
    12481 tttttgaaaa actattgaaa tctatacgca aatcctataa aataaaaata tcttgtggga
    12541 cttaaataaa cactagggac aaaaaaagtc ccgaaaggaa agcaataagg agtatgttat
    12601 gaagaactta ttagaaattc aaaagaaatt gattccacag gcaattgaac ttatggaaag
    12661 aagatactct attttaagac aaatatcttt aagtgaacca ataggtagga gaacattatc
    12721 aaatgtatta gagattagtg aaagaataat caggtcagaa actgagtttt taaaagaaca
    12781 aggacttata gacgtagctg tatctgggat gactatcact aaagaaggtt ctgatttgtt
    12841 agataaactt aaggacatca tgagtgacat catgggattg tctaagttac aagatagagt
    12901 cagagaaaag cttggaataa aaagggtaat attagttcct ggaagctgtg atgaaaatgg
    12961 aagtttacta aaagatgtaa ctagatatgg atgcgaatat ttcttaggca ttttaaaaga
    13021 tggagatatc gtttcaataa caggaggaag cactatgttg gagttttcaa acgttattaa
    13081 aactgataag agatatccaa actctacaat agttccagct agaggaagta tgggaactga
    13141 tgtagagatg caatctaaca atatagttgc ttcaataagt aagaaattac attctaattg
    13201 caaactttta catataccag atgagttgga tgaaagtgca atgaaaactc ttagccaagt
    13261 gccagagatt aagacaactt tggagtatat taaaagaaca gacattttag tttttagtat
    13321 aggtagagca gatgtcatgg caaagagaag aaaacttcca gaagacaagg ttgatgagat
    13381 attatctaaa aatgcagttg gagaagcatt tggatattat ttcaacaaag atggagaaat
    13441 agtttacaaa ctgaacactg ttggaattga tttagaaaca gttaaacaag taaaagaaac
    13501 tattgcaatc tttgcaggga ctgaaaaagt agaagcctta ttagctatat caaatatgca
    13561 taaaaacatg gttcttgtaa cagatgaaga aagtgcttat aagatattgt cattattata
    13621 aaagtcaaga cctagcacag agctagaaaa catacattta ctttatagga ggtagcgaaa
    13681 atggttaaag tagctataaa tggatttgga agaataggaa gattagcatt aagaaaaatg
    13741 atggagcaac aagataagtt cgaagttgtt gcaataaacg acttaacaga cgctaaaatg
    13801 ttagctcatt tatttaaata tgatacagct caaggaagat ttaacggaga aatagaagtt
    13861 aaagaaggtg cttttgtagt aaacggaaaa gaaataaaag taacagcaga aagaaatcct
    13921 gctgacctac catgggctga attaggagta gatatagtat tagaatgtac aggattcttt
    13981 acatctaaag ataaagctga agctcatata caagcagggg ctaagaaagt tgttatatct
    14041 gcaccagcta ctggagattt aaaaacaata gtattcaaca caaacagtga catattagat
    14101 ggttctgaaa cagttatatc aggagcttct tgtactacta actgtttagc tccaatggct
    14161 aaagtattaa atgataaata cggtatagaa aaaggattaa tgactactat acatgcatac
    14221 actaatgacc aaaatacttt agatggtcct catccaaaag gtgatttaag aagagctaga
    14281 gctgctgctg gaaacatagt tccaaacact acaggagctg caaaagcaat aggcttagta
    14341 ataccttcat taaaaggaaa attagatggg gcagcacaaa gagtaccagt tgtaactggt
    14401 tcaataactg aattagtttg tacattagga aaaaatgtta cagttgaaga aataaatgca
    14461 gctatgaaag aagcttcaaa cgaatctttc ggatatactg aagaaatgtt agtatcttct
    14521 gacataatcg gaataagcta cggttcatta tttgacgcta ctcaaacaaa agttatggaa
    14581 gtagatggaa aacaattagt taaagttgtt tcttggtatg ataatgaaat gtcttatact
    14641 tctcaattaa taagaacttt aggatacttt gcacaattag caaaatagtc agttttgaga
    14701 aaatagaaaa gtagattgac aaagtccgag tttgtagttt aatactacgg actcaggact
    14761 ttttttaaga aaaaatatat aaaatacacc taaataatgt tacatactat atataaaaat
    14821 atgataatat gatatattta atagggtaaa agtatgtact atattatact tggcaataaa
    14881 aaattacttt attaaaagga gagatattta tgtcaatgct taacaaaaaa actatagaag
    14941 atattgatgt gtgcggaaaa aaagtattag taagatgtga ctttaatgtg ccattacaag
    15001 atggtgtaat tactgatgaa aatagattga acggagcttt accaactatt caatatttaa
    15061 tttctaaagg ggcaaaagtt atattatgct ctcacttagg aaagccaaaa ggagaagcta
    15121 aaccagaatt atctttagca ccagtagcaa agagattatc tgagatgtta ggaaaagaag
    15181 ttgtatttgc agcagacgat aatgttgtag gagaaaatgc aaagaaagca actgaaaaaa
    15241 tggaaaacgg agatgtagta ttattagaaa atactagata tagaaaagaa gaaactaaaa
    15301 acgaagagaa tttctctaaa gaactagcat cacttgctga aatatttgta aatgatgcat
    15361 ttggaactgc tcatagagca cattgctcaa cagttggtgc aggcgagttt ttacaagaga
    15421 gagtttgtgg atacttaatt caaaaagaat taaaattctt aggagaagct gttgcaaacc
    15481 ctgtaagacc atttacagct atacttggag gagctaaagt ttctgataaa ttagctgtta
    15541 taaacgaatt attagaaaaa gttgataatc taataatagg tggaggaatg gcttatacat
    15601 tcttaaaagc tcagggttat gaagtaggaa cttctttact tgaaatagat aaagttgaat
    15661 atgctaaaga aatgatggaa aaagctaaga ataagggtgt taacttatta ttaccagtag
    15721 acgttgttat ggcagaccac tttgcaccag atgctactcc aatagtaaca gaagatgcta
    15781 atgtaaaaga agattacatg ggactagata tgggacctaa gactatagca aactttgtaa
    15841 aaactataaa agaatcaaaa actgtagtat ggaatgggcc aatgggagta tttgaatttg
    15901 aaaactttgc aaatggtaca ttatcagtag ctagagctat ggcagagttg actgatgcaa
    15961 ctactgtaat tggcggtgga gatagtgcag cagcagttaa tcaattagga tttggtgaca
    16021 agatgactca cgtatcaaca ggtggaggag catcactaga atttttagaa ggtaaagaat
    16081 taccaggtat tgcagcatta gataataaat aaactaatat atagaggaga ttgtaaaatg
    16141 agaaaaccta taattgcagg aaactggaaa atgcataaaa caataaaaga agctttagaa
    16201 tttgtaaatg aagttaaaga taaagtaaat tctgataaag tagaagctgt tatatgtgca
    16261 ccatttactt tattaaagga tttaaaagaa gctactaagg gtacaaatat aaagataggt
    16321 gctcaaaata tgcactttga agaaaaagga gcatttacag gagaagtttc acctcttatg
    16381 ttaaaagaaa tagatatgga ctatgttgta ataggacatt cagaaagaag acaatacttc
    16441 aatgaaactg atgaaactgt aaacaagaaa gttttaaaag cattagaagt aggaatagac
    16501 ccaatattat gtgttggaga aactttagaa caaagagaag ctggaaaaac taaagatgtt
    16561 tgtaaagttc aagttgaaaa agctttagaa aatgttctta aagatgattt agcaaaagta
    16621 gttgttgcat atgagccaat ctgggctatt ggaactggta aaactgcaac tgctgaagat
    16681 gctaatgacg ttatatctta tataagagaa gttataaaag gattatatgg agaattagct
    16741 aatgaagtta gaatacaata cggtggaagt gttaaacctt caaatgtagc cgaaataatg
    16801 ggtcaaagtg atatagatgg agctttagta ggtggagcta gtttagctag taatgattac
    16861 ctagaccttg ttaatttcta aggagtgaaa tgatgaaaaa accagttgct ttaattatta
    16921 tggacgggtt tggatacaat aaggatgtta agggaaatgc aattgctgag tccaaaactc
    16981 ctaatttaga tagaataaaa aaagagtatc caaacacatt gataaatgct agtggtcttg
    17041 atgttggtct acctgatggt caaatgggaa attcagaagt tggacacact aacataggtg
    17101 caggtagaat agtatatcaa gatttaacta gaataacaaa atctataaaa gatggtgact
    17161 tttttactaa taaagtttta tgtgaagcaa tggataatgc aaaagaaaat tctcttcatg
    17221 taatgggact tttgtctgat ggaggagtac attcacatat agaccatctt aaggctataa
    17281 tcaaaatggc aaaagataaa ggcgtacaaa aggtgtatgt tcacgcattt actgatggta
    17341 gagatactga ccctcaaagt gcattagaat atgccaaaga agtacaagct agtatggatg
    17401 aaattggagt aggtgaattt gctacagttt ctggtagata ctacgctatg gatagagata
    17461 agagatggga aagagtagaa cttgcataca atgccatggt tagaggtatt ggtgaaaaag
    17521 caaattctat tgaggaagct attcaaaact cttatgatga tggaaaaaat gatgagttta
    17581 taatgccaac agttattatg aaagatgata aaccagctgg aagtataaag gaaaatgatt
    17641 caattatatt cttcaacttt agaccagata gagctagaca aataactaga gctttagttt
    17701 gtgaagagtt tgatggattt aaaagagaag atattaaaaa cttctttgta tgcttaacag
    17761 agtacgatat aactatagag aatgtgcata tagcatttgg acctcaatct ttagccaaca
    17821 ctctaggtga gtatctagct aaaaatggaa aaactcaact tagagctgct gaaactgaaa
    17881 agtatgcaca tgtaactttc ttcttcaatg gtggagtaga agagccaaat aaaggtgaag
    17941 aaagactatt gataccttct ccaaaggttg caacttatga tttaaaacca gaaatgtcag
    18001 catatgaatt gacagataaa gctttagata aattaggaga agataagttt gactttatag
    18061 tattaaactt tgcaaatcct gatatggtag gtcatacagg aagtatagaa gcggctataa
    18121 aggctgttga aactgtagat acttgtgtag gaaaattgat agataaaata gtagagttgg
    18181 gtggaagtgc aataataact gctgaccacg gaaatgctga atatatgtta gacccagaaa
    18241 caggaaaaac tgtaacggct cactctatta atccagtacc atttattgta gttggtcaag
    18301 aatatgaaag tgcaaaatta ttggatggag gaagattatc tgatatagca ccgactgttt
    18361 tagatatgat gaagttagaa aagccagaag aaatgactgg tcattcactt atttcaaaat
    18421 agtcgatttt gataagtaga gaataatata taaactacaa tataaattta aaaataatgc
    18481 agtttaggtt tattttgtaa agtttagact ttatgacata agatttaaat tttgtaagtt
    18541 ctggatattg taaggtgtag atgaagatat attttataaa atttacaaga tagacaattt
    18601 ataaaataaa aaattacaa
//
LOCUS       DAEQCW010000074        18548 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.074, whole genome shotgun sequence.
ACCESSION   DAEQCW010000074 DAEQCW010000000
VERSION     DAEQCW010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18548)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18548)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18548
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.074"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            197..1357
                     /locus_tag="KRO40_002520"
     CDS             197..1357
                     /locus_tag="KRO40_002520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBH2093337.1"
                     /translation="MIETGFVYCSFLVVFVGVIFFMVDKLKWKVFDVINPMLLIYLGS
                     AILGSFGLFAQNEDVGTYQNIITVNFLPLMLVFLLIQCDLRKILKMGPKMLLSFFCAT
                     FTFMLGFVIAFIIFKNSMGADSWKILGAASGSWIGGSSNMIAAANALGVAEEGLSYAI
                     LMGSIGYTVWMSVCLMSVKFGPKFNKWTKCDTSFIDEVTSKLEKENKDNTAPTFVELM
                     ILLSVGFGVASFAQIVSKILPTSGILNETMWVVLVASTVSILLGMTKISKLKGSTLVG
                     NVFMYLLLAATGSKANFFGLSEAPVYIMFGLVVVLVHAISFIGLAKLFKLDLFTCEVG
                     SIANIGGVTTAPMIAGVHNPVLIPVGVLMGLLGNIIGTYCALMVTQILHMLA"
     gene            1699..1860
                     /locus_tag="KRO40_002521"
     CDS             1699..1860
                     /locus_tag="KRO40_002521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093338.1"
                     /translation="MIIPSRRIQDITLTNLKNGEVTLIELDEIYKKMGFLFVVSEGKL
                     KKIKKENHH"
     gene            2053..2682
                     /locus_tag="KRO40_002522"
     CDS             2053..2682
                     /locus_tag="KRO40_002522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HBH2093339.1"
                     /translation="MKIVTYNIHKGMDSNNRLTLTKMGLYLKQLDCDVICLQEVLYPQ
                     FLALKAVLNMDGVFATNVKKVNMIYGICTFTTSKMLNSNHFFLTSKKEQRGALCITID
                     AYGRIINVINTHLGLDRQERAKQLDEIIDYRNRLVGIVILCGDFNEKNVFLSMFNDMA
                     ISLNKSYLPTFEKSNSRIDYIFVNKNTELKGYTVEKIYLSDHYPVIGYI"
     gene            2921..4180
                     /locus_tag="KRO40_002523"
     CDS             2921..4180
                     /locus_tag="KRO40_002523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBH2093340.1"
                     /translation="MGRRTTRVSRLGKEKKRSVLIVLAALVLIMGGFTYFFNSKFLYN
                     GKIAKNVYIEGVNVSDMTKAEALKAITDKYTPEDLNLAYDGKKYTISPKDIDLKYDTE
                     DVVKDAYESTKKGSYFQNLKKYIDIRVNKANMKIKAEYDEAKLSSKVSSIADSINVKM
                     KNASISVGSGGLSYTDSVVGREFDLAANKESIYNMIKNKEHKTLELKVNLQKPDITTE
                     QVKTVNSVIGQYSTTYSQAVEGRSYNVGLSARKTSDVLLMPGEEFSYNKLTGPSNKAN
                     GYKDAPVIVYGKLEQSAGGGVCQTSSTVYNAALLSGMEITQVTNHSSASTYVPKGRDA
                     TVSDGGLNLKFKNPYKHPVYIKNYAGGGSVSSVIYGNSGDKPNISIEVKQTGQNKYST
                     YRIFKDSSGKVIKKEHISNSSYKELKK"
     gene            4439..5434
                     /locus_tag="KRO40_002524"
     CDS             4439..5434
                     /locus_tag="KRO40_002524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase"
                     /protein_id="HBH2093341.1"
                     /translation="MYEEVTWLNFIGNRYEVVNSDDVLEINKIYKARDVFYRKNVLIK
                     VIKHNNYICEDFVSNLIDESTALDEINSPYILKIIDVGIHCTEETTLYYVVSEDFNGI
                     GLDELILGNYLHLEAIVNIMIQVLKALEMIHRNHSYHGSLKSSSIIVDTEYNIKICDF
                     GITKANNGVNTRSYGNRRYLCPHQLCINYTDKESDFFATGLILFESIFKKLPFGESNS
                     EEKMLQSIDKGLDWNSIKAINGNTELINVIKRLLGRNNKYTRANDIIIDLSKVMYEKA
                     YIEVEDEKEEEQKQDKVIQVKKEYKSKMRKKLHKKLVVAGLAIVMISMIIISSII"
     gene            5680..6747
                     /locus_tag="KRO40_002525"
     CDS             5680..6747
                     /locus_tag="KRO40_002525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA ligase RtcB family protein"
                     /protein_id="HBH2093342.1"
                     /translation="MSNIKIIASNKCWIEDIARKQLEDISKLNGILRVVGLPDLHAGK
                     IPVGLAVETKNIIYPHIIGNDIGCGMTLFKTGVLKKKFKKDKWIKSLSKIKDLSDIEI
                     KNTYKEECPILNLGTIGSGNHFVEIQCISEIYNKEQFEQLKFSSDDIMMLVHCGSRNY
                     GEDILKKFYDKDGLEVESEKAIDYIKKHDNALMWAERNREAISKKIMQSIGTSGDVET
                     IFSINHNFVEKREDKFIHRKGAVSSERGAVIIPGSRGSLSYIVMPTENTEISLYSLSH
                     GAGRKWSRSVCKSRLKSKYSKDTIKQTKFKSQIICNDVNLLFQEAPEAYKNIEQIIES
                     LIEYELIQVVATMKPLITYKG"
     gene            7281..9191
                     /locus_tag="KRO40_002526"
     CDS             7281..9191
                     /locus_tag="KRO40_002526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBH2093343.1"
                     /translation="MNSNTFERLQLNEVKELIKIHCVSSLGKNLIDKLTPSGNIGVVR
                     RKLAENKEARKIIENSNHIPLEGLFNAGSTIDKIEKGMIIEPVELVNIEDFLRGCRKM
                     KAFMLEKEFYSPTLSSYALNITECKSIEDEINYCIKSNKVDSNASKELKKIRRNIEIT
                     EGKIKDRLNKFITSTVNKKYIQEFIISKRNDRYVIPIKSSYKNEVNGTILDTSSKGNT
                     VFIEPISVSNLSTELTMLKADETIEEYKILSYLTELIFEKISQIKLNIEILSEYDMLF
                     AKAKYSQKIKGITPKINNNGYIKIIKGKHPLLTGDAVPLDFEIGKNYRSLIITGPNAG
                     GKTVTLKTVGLLTLMVQCGFDISAKEGSEFSVFEKVFVDIGDNQSIENALSTFSSHIK
                     NIAEIMSLSNNSTLVLFDEIGSGTEPNEGAGLAISLLEEFYKMGCITIASTHYGEIKK
                     FATLHPEFENAGMMFDKETLEPLYKLTIGKSEDSNALFISKKMGIKNRVLDRAKEYVI
                     DRNYNLDLVKRSKLQSNIEDKNSSEVILNYTDYNVGDKVKLLDEDDFGIVYKPMDKFN
                     NVEVLFNDNFVSVNIKRLQLSIKASELYPEGYDLDVLFTSFKERKLEKDIQRGSKKAL
                     KKIQKEIRENRK"
     gene            complement(9254..9877)
                     /gene="ytaF"
                     /locus_tag="KRO40_002527"
     CDS             complement(9254..9877)
                     /gene="ytaF"
                     /locus_tag="KRO40_002527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation membrane protein YtaF"
                     /protein_id="HBH2093344.1"
                     /translation="MIESILLVTSLCIDAFVTSFGYGVNKVKVPLYSNIIISVVCSAI
                     LAISLFAGTIVRDFLPQNITMLICFFILFLLGSARLIESFFKSYFKKKSIHSKNYNFN
                     MLDLKLNFNVSIEPDVLDTSKSKVLKSAEAFTLALALSLDGLAIGFGSGLVGVNYIQV
                     ILFSLISNIIAVLLGCLLGNMFVKNVNLNLSWLSGLILLVIGFMKIC"
     gene            10065..10709
                     /locus_tag="KRO40_002528"
     CDS             10065..10709
                     /locus_tag="KRO40_002528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093345.1"
                     /translation="MEQNNKVGNFGDLLKILLDEKELSMGELSKKSGIDKSTISRIAN
                     NKQKPNINHLEKMAIHLNINLEELLKASGYEFRNSNNQIFNADSDFSNFDDILGFANL
                     INDKNFNGNIEKELSKCKLYVQTDEGKKLLFDNFNKKIDSIEKQGQFTDRLRQMYADF
                     CTDGLTIKKYLLIGSMLLYFVISTDVIPDFVFPIGFMDDLVALNIVTKLLKNDK"
     gene            10923..11981
                     /locus_tag="KRO40_002529"
     CDS             10923..11981
                     /locus_tag="KRO40_002529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HBH2093346.1"
                     /translation="MNCKWISKIDERKKCHREADSSGYCIFHKENKSDEEIQLMMDTL
                     HKEEISEFNGFVFENEFNAEEILTYNYKILDFSESIFKQKANFKKYIFKKNIIFNYTE
                     FRDKVLFNGCVFLENCDFNRTIFSKHYINDRIFEKVKFKGPDLVVNKVENFPRMDGII
                     FSMCTKFVLKNVEYGKSEYEHGKINYRIARNQATKIGEYEMIGFYYYKERIYSSKIMK
                     RSNYPTFSDYLVEKFFDQIARYTTGYGEKPWNILLVIIAIISVFALLYLFVGIESSNS
                     TLVALDINNIGDYSLSEIFKMYMDLWYFSMATFSTVGYGDMVATSLIGKALAGIEVFF
                     GVTIGAIWASVIIKRMIR"
     gene            12085..13269
                     /locus_tag="KRO40_002530"
     CDS             12085..13269
                     /locus_tag="KRO40_002530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBH2093347.1"
                     /translation="MKNALKKIISLAMILVFIIPNYSYADDKSVDKYSKTSILIDQET
                     GRVLYSKEPDMKVPLASLSKMMTFLLAIEAIENKEVKETDKVKIDKSIASVKGSSYKL
                     KDGEEVPLIELMRGLMIVSGNDAAIAIAKHVCKTKEAFVDRMNKKAKEIGMSNTHFLN
                     PNGLPIYDLSNPKKPAKENISTAKDIAILGKYMFDHYEKQVTAITDMETYTNSDRSFE
                     KSNTNALLRIIPEVDGIKTGYTGNAGYCLSFSMVVNKNDKNEKKRRVIGVVLGTNHKN
                     KRTSASLALLKYGKENFNMKKVIDKDSFIGKKYIKGTKELEVTLKAKDELYTILKDDE
                     SIKSEVKIKNIEYPVKKGDTMGIIKYYTNSGDLLGSVDIVSNNSIDNVSLKTKLKMKF
                     AN"
     gene            13476..14189
                     /gene="rpsB"
                     /locus_tag="KRO40_002531"
     CDS             13476..14189
                     /gene="rpsB"
                     /locus_tag="KRO40_002531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HBH2093348.1"
                     /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIYIIDLQ
                     KTVKKVEEAYKFTKEVAETGKPILFVGTKKQAQDAIKDEAERCGMYFVNERWLGGMLT
                     NHKTIKTRINKLRELEKMEEEGVFNVLPKKEVIKLRAEKEKLEKYLGGIKDMPELPGA
                     MFVVDPRKENIAIQEAHRLGIPVVGIVDTNCDPEQLDFAIPGNDDAIRAVKLITGAMA
                     TAVIEGRQGAEEEVAEDQE"
     gene            14268..15179
                     /locus_tag="KRO40_002532"
     CDS             14268..15179
                     /locus_tag="KRO40_002532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HBH2093349.1"
                     /translation="MANITAQMVKELRESTGAGMMDCKKALQEAEGNMEKAVDLLREK
                     GLSKAAKKAGRVAAEGLVAIEMNDDNTVASMVEVNSETDFVAKNEDFKVFVKDAACMA
                     LATDKEDIASLLGETHKEGITLQEVLNNRVAKIGEKLDFRRFAKVVTNGQVAGYIHGG
                     GKIGVLVEMETEARDAKVLELGKDVAMQVAAMNPKYVSRDEVDAEYIAHETEVLTQQA
                     LNEGKPANIVEKMVKGRLEKELKEVCLLEQTFVKNPDITVKQLVADVAKAVGSDIKVV
                     KVVRFEVGEGIQKREENFAEEVAKQLK"
     gene            15264..15968
                     /locus_tag="KRO40_002533"
     CDS             15264..15968
                     /locus_tag="KRO40_002533"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HBH2093350.1"
                     /translation="MDKPMYKRVLLKLSGEALAGERGFGINNDVVNDIAIAIKKIQEI
                     GVEVAVVVGGGNFWRGRTSEGMDRTTADYIGMLATVMNAMALQDALENIDVATRVQTA
                     IDMRQIAEPYIRRRAVRHLEKERVVIFGAGTGNPYFTTDTTAALRAAEMEAEVILLAK
                     NVDAVYDKDPKVHADAKKFTELSYMEVIQKELKVMDSTATSLCMDNKIPIKVFELTTE
                     NIIRAVKGENIGTTVK"
     gene            15994..16551
                     /gene="frr"
                     /locus_tag="KRO40_002534"
     CDS             15994..16551
                     /gene="frr"
                     /locus_tag="KRO40_002534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HBH2093351.1"
                     /translation="MKLEIHKQLEEKMNGTIDALKFEFGTIRAGRANAQMLDKIRVDY
                     YGTPTPINQIGAISVPEPRILMISPWDKSAMHEIEKAIANSDLGLNPSNDGEVIRLSV
                     PALTEERRKELAKKASKAAEEFKVRIRNERRDANEKIKKMEKGGELTEDELKKAQDEV
                     QKMTDKFIKEIDTLLSKKEKDIMEV"
     gene            16554..16757
                     /locus_tag="KRO40_002535"
     CDS             16554..16757
                     /locus_tag="KRO40_002535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093352.1"
                     /translation="MKKYYNLLGLHVDEVKQYFDEQNINYTVKSIEGKKDKEKLVVPR
                     VIKISEIGDSVELIITYFSDSLV"
     gene            16786..17520
                     /locus_tag="KRO40_002536"
     CDS             16786..17520
                     /locus_tag="KRO40_002536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HBH2093353.1"
                     /translation="MNNNIIYDIDLNNIPTHIAIIMDGNGRWAKARFLPRTAGHKAGV
                     ETIRDIVKECSKLGVKHLTLYAFSTENWKRPKLEVDTLMNLLSTYLRNEIAELHQNNV
                     KVTAIGDISALPKTCIRELNSAKELTKNNTGVNLNLALNYGSRADIKNALIDIVKNCE
                     SGKIDINNIDEDIIKNYLSTKSIPDPDLVIRTSGEQRLSNFLLWEVAYSEFYFTDIHW
                     PDFKKEELQKAIYVYQRRDRRFGGLK"
     gene            17533..18312
                     /locus_tag="KRO40_002537"
     CDS             17533..18312
                     /locus_tag="KRO40_002537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HBH2093354.1"
                     /translation="MLTRIIASLALVPLFLFVVYGGIPLYIAETAIVYIALHEFYKAF
                     KIKDVHPIFIIGYLFSIYLAVKNIFNLPLEYTYAVIFILFLASIIYMLMGKNNVIDVS
                     ITFLGVFYIGVFLDFIIITINGFEKGSIYVWLIFVISFMTDIFAYFSGYLLGKHKLIP
                     KVSPKKTIEGAIGGIIGSTLCCILFGYLFGIDLLQLAIIGSIGSVIAQLGDLFASSIK
                     RYVGIKDYGKIIPGHGGILDRFDSVILVAPFVYSAIKFFIR"
BASE COUNT         7618 a         1856 c         3227 g         5847 t
ORIGIN      
        1 ttaaattcag attattcatt tctaaagtaa ttaatgtgca aatctttatt aatatatgtc
       61 aatagttagg tatatatgta tttaattagt atgatataga taaaagtatt tattttaatt
      121 gtctattatc tgaaaaagtc tttacttaga aatcataaaa atcaaattaa ttaggaaaag
      181 aaagggtgtg tataatgtga ttgagactgg atttgtatat tgtagtttct tggttgtatt
      241 cgtaggtgta atttttttta tggttgataa attgaaatgg aaggtatttg atgttattaa
      301 tccaatgctt ttaatatact taggttcagc tatacttgga tcatttggtt tatttgcaca
      361 gaatgaagat gttggaacgt atcaaaacat aataacagtg aacttccttc cattaatgtt
      421 agtgtttttg ttaattcaat gtgatttaag aaaaatatta aagatggggc ctaaaatgtt
      481 attatcattt ttctgtgcta catttacatt tatgcttgga tttgttatag cattcataat
      541 ttttaaaaat tcaatgggtg cagattcatg gaaaattctt ggggcagcat ctggttcatg
      601 gataggtggc tcatcaaata tgattgcagc agctaatgct ctaggagttg cagaagaagg
      661 acttagttat gcaatactta tgggttctat aggatataca gtatggatgt ctgtttgtct
      721 aatgtctgtg aaatttggac ctaaatttaa caaatggaca aagtgcgata caagttttat
      781 agatgaggtt acatcaaaac ttgaaaaaga aaataaagat aatacggcac ctacgtttgt
      841 agaacttatg attttacttt ctgttgggtt tggagttgcg tcttttgcac aaattgtatc
      901 caagatactt ccaacttcag gtatacttaa tgaaactatg tgggtagtac ttgttgcatc
      961 tacagtatca atattattgg gtatgacaaa aatatcaaag cttaaaggga gtacactggt
     1021 aggaaatgtg tttatgtatt tactccttgc agctacaggt agtaaagcaa atttctttgg
     1081 attgtcagaa gcacctgttt acataatgtt tggattggta gtagtccttg tacatgctat
     1141 ttcatttata gggcttgcta aactatttaa acttgattta tttacttgtg aagtaggaag
     1201 tatagctaat ataggaggag taactacagc tccaatgatt gctggggttc acaatcctgt
     1261 attaatacca gtaggtgtac ttatggggct tctaggaaat attataggga cttattgtgc
     1321 tcttatggta actcaaatat tacatatgtt agcttaataa aaatatggta taaaattaat
     1381 aatttaaata agaaaagtca tttcaattta agcagaagct tttactgaaa tggctttttt
     1441 gtttgacaag ataatctatt tcaagaagat gttttgacat atttagtgta taatattgta
     1501 aaatttacta aaaacgagat atatttaatt tttatattga atcgaacgtc tgtatgatgt
     1561 ataataaata tacagaacga atgtttgtag aacgggtgtt ttttgaattt attttaataa
     1621 tttatgaata tatatcagaa tgcataaata tatttaaata taaagattaa aaagaattta
     1681 aaggagtgtt gataacttat gataattcca tcaagaagaa tacaagatat aacattaaca
     1741 aatttaaaaa atggtgaagt aactttaatt gaattggatg aaatatacaa gaagatggga
     1801 tttttatttg ttgttagtga aggcaaattg aaaaagataa aaaaggagaa tcatcattag
     1861 aaatgaatga aataataaat attataatag tttataaaac ctaacttatg tagaatataa
     1921 atacttaagt taggtttttt tgtgataaag tttataagta ctcaatttta taagataaat
     1981 aatggtctta agtgaaaagt aaataagttt aaattttagt aagtattata ttgcataaga
     2041 ggtgatatta ttatgaaaat agtaacctac aatattcata aaggtatgga ttcaaataat
     2101 agattaactc taactaaaat ggggttatat ttaaaacaat tggattgtga tgtaatttgt
     2161 ttgcaagaag tattatatcc tcaattttta gctttaaaag ctgttttaaa tatggatggt
     2221 gtctttgcga caaatgtaaa aaaagtaaat atgatatatg gtatttgtac atttacaaca
     2281 tctaaaatgt taaacagtaa tcattttttc ttaactagca aaaaagaaca acggggagct
     2341 ctttgtataa ctatagatgc atatggaaga attataaatg taataaatac tcacttggga
     2401 cttgataggc aggagagagc aaaacaatta gacgaaataa tagactatag gaacagatta
     2461 gtggggatag ttattttatg tggtgatttt aatgagaaaa atgtcttttt aagtatgttt
     2521 aatgatatgg ctatttcact aaacaagtct tacttaccaa catttgaaaa atcaaactct
     2581 agaatagatt acatttttgt taataaaaat actgaactaa aaggatacac agtagaaaaa
     2641 atttacctgt cagaccatta tcctgtaata ggttacattt aaatttcaat ataaatgaaa
     2701 ttagttgtta taaaataaac aattttttgt taagaaatag taaaagaaat ataataaaaa
     2761 atatcaaaaa taaaactaat tataagacat aaatttacaa taaagttaca tttgattaaa
     2821 ttccttgttt aacaaaagct attcaaatat aatctaaggt agttttgaaa tgggaactct
     2881 attatgcaaa tttaagctag tgttaaaatg aggtgaagtt atgggcagaa gaacaacaag
     2941 agtttcaaga ttaggtaaag aaaaaaaacg aagtgtttta attgtattgg cagctttagt
     3001 tctaataatg ggtggattta cttatttttt taacagtaaa tttctgtaca atgggaaaat
     3061 cgctaaaaat gtatatatag aaggagtaaa tgtatctgat atgactaaag cagaggcatt
     3121 aaaagctata acagataagt atactccaga agatttaaat cttgcttatg atgggaaaaa
     3181 atatacaata tcaccaaaag atattgattt aaaatatgat acagaagatg ttgtaaaaga
     3241 tgcttatgaa agtacaaaaa aagggtccta ttttcaaaac ttaaaaaaat atattgatat
     3301 aagagtgaat aaggcaaata tgaagataaa agctgaatat gatgaggcaa aacttagttc
     3361 caaagtgtct tctatagcag atagtataaa tgttaagatg aaaaatgctt ctattagtgt
     3421 tggaagtggt ggactaagtt atacagactc tgttgtaggt agagaatttg atttggcagc
     3481 aaataaagag tctatatata atatgataaa aaataaagag cataaaactt tagaacttaa
     3541 agtaaatctt caaaaaccag atataacaac tgaacaagta aaaactgtaa attctgttat
     3601 aggtcaatat tcaactactt attcacaagc tgtagagggt aggtcatata atgtaggatt
     3661 atcagcaaga aaaactagtg atgtattatt aatgccaggt gaagaatttt catacaataa
     3721 acttacagga cctagtaata aagcaaatgg ttacaaagat gcacctgtta tagtttatgg
     3781 taagctagaa caatcagcag gaggaggtgt ttgtcaaaca tcttcaacag tttataatgc
     3841 ggctcttctt tcgggtatgg agataactca agttacaaat cattcatctg catctactta
     3901 tgtgcctaaa gggagagatg ctactgtgag cgatggagga ttaaacttaa agtttaaaaa
     3961 tccatataag catcctgtat atattaaaaa ttatgcaggt ggaggaagtg tatcatcagt
     4021 aatctatggt aattctggtg acaaaccaaa tatatctata gaggtaaaac aaactggtca
     4081 gaataaatat tctacatatc gaatatttaa agattcaagt ggaaaggtca taaaaaaaga
     4141 acatatatca aatagttctt ataaagaatt aaaaaaatag ataatttttt agagaaatat
     4201 ttgtaatata aaagggagtg tctcaaaatg aactttttag tttatgaggc actctttttc
     4261 tgtgaaatca aatatatttt catcatttca acaatacaaa agaagcgtat ctctattttg
     4321 agacagcctt ttttgtaaaa attaacacta ttagttcttg ttttaatatt acaatcatta
     4381 atatatagaa aatattccta tatattggta taattgtaaa tagatttagt tatataaaat
     4441 gtatgaggag gtgacatggt tgaattttat aggcaataga tatgaggtag taaattctga
     4501 cgacgtttta gaaattaaca aaatctataa agctagagat gttttttaca ggaaaaatgt
     4561 gttaataaaa gttataaagc acaataatta tatctgtgaa gattttgttt caaatttaat
     4621 tgatgaaagt actgctttag atgagataaa ctctccttat atactaaaaa taatagatgt
     4681 tgggattcac tgtacagaag aaacaacatt atattatgtt gtaagtgaag actttaatgg
     4741 tatcggacta gatgaattaa ttctaggtaa ttatcttcat ttagaagcaa ttgtaaacat
     4801 aatgatacaa gttttaaaag ctttagaaat gatacatagg aatcattcat atcatggtag
     4861 tttaaaatcg agtagtataa tagtagatac agaatacaat ataaaaattt gtgattttgg
     4921 aattacaaaa gcaaataatg gggttaatac aagaagctat ggaaacagga gatatttatg
     4981 cccacatcaa ctatgtataa attatactga taaagaaagt gatttttttg caacaggtct
     5041 tattctattt gaatctatat ttaaaaaatt gccttttgga gaatcaaatt cagaagaaaa
     5101 aatgctacaa tctattgata agggattaga ttggaatagt ataaaagcaa ttaatggaaa
     5161 tactgaactt ataaatgtta taaaaaggct tcttggaaga aataataagt ataccagagc
     5221 caatgatatt attattgatt taagtaaagt aatgtatgaa aaagcatata tagaagttga
     5281 agatgagaaa gaagaagagc agaaacaaga caaagttata caagttaaaa aagaatataa
     5341 aagtaaaatg agaaaaaaat tacataaaaa acttgttgtt gccggtctag ctatagtcat
     5401 gatttcaatg attattatta gttccataat ataaaaattg tatattaagt attttaaaat
     5461 caatgtctat aaaggatata catagaaatt ttagtgtagt cttaaattat gaaaggaagt
     5521 ggttattatg ttaacaaaaa ataatgaggt attaaacgtc taggagtatt ttaacaaata
     5581 gccacctgct tttacagttt agaataaaaa agctgtggct aaaggtcaca gctttttgct
     5641 actttttaaa ggcaggagaa tattaaaaag gagcaaatta tgagcaatat aaaaataata
     5701 gcaagtaata aatgttggat tgaagatata gcaaggaaac aacttgaaga tatttcaaag
     5761 ttaaatggaa ttttaagagt agtaggatta cctgacttac atgcaggtaa aatacctgta
     5821 ggtttagcag ttgagactaa aaatattatt tatccacata taattggaaa tgatatagga
     5881 tgcggaatga ctttatttaa aactggagtt ctaaaaaaga aatttaaaaa agacaaatgg
     5941 attaagtcac ttagtaagat taaagatttg tctgatatag aaataaaaaa cacatataaa
     6001 gaagaatgtc caattttaaa tttaggaact atagggagtg gaaatcattt tgtagaaatt
     6061 caatgtataa gtgaaattta taataaagaa caatttgaac aattaaaatt ttcatctgat
     6121 gatattatga tgttagttca ctgtgggtca agaaattatg gagaagatat tttaaaaaaa
     6181 ttttatgata aagatggact tgaagttgaa agtgagaaag ctatagatta tattaaaaaa
     6241 catgataatg ctttaatgtg ggcagagcgt aatcgtgaag ctatcagtaa aaaaattatg
     6301 cagtcaatag gtacatctgg agatgttgaa acaatattct ctataaatca taactttgta
     6361 gagaaaaggg aagataaatt tatacataga aaaggtgctg tttcaagtga aagaggagct
     6421 gtgattatac caggttcaag aggcagtcta tcatatatag ttatgcctac tgaaaataca
     6481 gagatatctt tatattctct atcacatgga gcaggtagga aatggtctcg ttcagtttgt
     6541 aaatctcgcc ttaaaagtaa gtatagtaaa gatactataa aacaaactaa atttaaaagt
     6601 cagattatat gtaatgatgt aaatttatta tttcaagaag ctccagaggc atataagaat
     6661 atagagcaga ttattgaaag tttgatagaa tatgaactta ttcaagtagt ggcaactatg
     6721 aagccattga ttacttataa aggataattt ttaaagttaa aaaagattaa aattatatta
     6781 taaatagcta attttatgga acatttaaaa gtgttttatt attagctatt tttttatttt
     6841 gtagagacga taatttatag agctaaattc tttgatatat aatgattaca aagttagact
     6901 gtattggaaa ctgcacatac atgaattgat gacaatataa gtgattccaa aatataaatg
     6961 aaagtataag cttattttca ctataaaaat tttcactgta caaaaacatt aatgacatta
     7021 tttttattga cataaatata taatttatgg aataatatta gaagcactga tataagtgtt
     7081 taaataagga tagaaaagga gaagtgtttt atgaaaaaaa atactaacat taatgagtcc
     7141 ggagttaaac ttcttaataa ataaggagtt tgatatataa taactcctta tttattaagt
     7201 tgttcgcaaa ataactatta tcaaagtaaa tgatagggtg atttaaaaga cgataactta
     7261 taaataaagg agaaaaaata atgaatagta atacatttga aagattacaa ctaaatgaag
     7321 ttaaagaatt aataaaaata cattgtgtaa gttcactagg aaaaaattta atagataaat
     7381 taactcctag tgggaatatt ggagtagtaa gaaggaaatt agcagaaaat aaagaagcta
     7441 gaaagataat tgaaaatagt aatcacatac cacttgaagg attgtttaat gcaggttcta
     7501 caatagataa aattgaaaaa ggaatgataa tagaacctgt tgaacttgta aatattgaag
     7561 attttttaag aggttgtagg aagatgaaag cttttatgtt agaaaaagaa ttttattcac
     7621 ctacattaag ttcttatgcc ttaaatataa cagaatgtaa aagtatagaa gatgagataa
     7681 attactgtat aaaatctaat aaagttgatt ctaatgctag taaagaatta aaaaagataa
     7741 gacgaaatat agaaattaca gaaggaaaga taaaagatag attaaataaa tttataacat
     7801 caactgtaaa taaaaagtat atacaagagt ttataataag taaaagaaat gatagatatg
     7861 taataccaat taaatcttct tataaaaatg aagttaatgg tactatatta gatacatcat
     7921 caaaaggaaa tactgtattt attgaaccta ttagtgtttc aaatttaagt acagagttaa
     7981 ctatgctaaa agctgatgaa actattgaag aatacaaaat attatcttat ttaacagaac
     8041 ttatatttga gaagataagt cagataaaat taaatataga gatactttca gaatacgata
     8101 tgttatttgc aaaagctaag tatagtcaaa aaataaaagg aattactcca aaaataaata
     8161 ataatggcta tataaaaata attaaaggta aacatccact tctaacagga gatgcagtac
     8221 ctttagattt tgaaataggc aaaaattata gaagtcttat aataacaggt cctaatgcag
     8281 gaggaaaaac tgtaaccctt aagactgttg gtttactaac tttaatggtt caatgtggat
     8341 ttgatatttc tgcaaaagaa ggtagtgaat ttagtgtatt tgaaaaagtt tttgtagata
     8401 taggggataa tcaaagtatt gaaaatgcct taagtacttt ttcatcacat ataaaaaata
     8461 ttgcagagat tatgagttta tcaaataatt ctactcttgt tctgtttgat gaaataggaa
     8521 gtggaactga acctaatgaa ggagctggtt tagcaatatc attattagaa gagttttaca
     8581 aaatgggatg tataactata gcatcaactc attatggaga gataaaaaag tttgctacat
     8641 tgcatccaga atttgaaaat gctggtatga tgtttgataa agaaacgtta gaaccattgt
     8701 ataagttaac tattggaaaa tctgaagata gtaatgctct ttttatttct aaaaaaatgg
     8761 gaataaaaaa tagagtttta gatagagcta aagaatatgt aattgataga aactacaatt
     8821 tagatttagt taaaagaagt aagctacaat ctaatattga agataaaaat agttctgaag
     8881 tcattttaaa ctatacagat tataatgtag gggataaggt aaaattacta gatgaagatg
     8941 attttggaat tgtatataag cctatggaca agtttaataa tgtagaagta ttgtttaatg
     9001 ataattttgt ttcagtaaat ataaaaagat tacaacttag cataaaagca tcagaattgt
     9061 atccagaagg gtatgattta gatgtattat ttactagttt taaagaaaga aaattagaaa
     9121 aagatattca aagaggttca aaaaaagctc ttaaaaagat tcagaaagaa attagagaga
     9181 atagaaaata aatataaaaa gcacaaaaga aagcaatcta aagagaaaag tttatcttta
     9241 gattgctttc ttattaacat atcttcataa atccaatgac taacaagatt aaaccactta
     9301 accaagataa gtttaaattt acgtttttaa caaacatatt tcctagtaaa caaccaagta
     9361 atactgcaat tatatttgat attaaagaaa atagaataac ttgtatataa ttcacaccta
     9421 caaggccact accaaaaccg atagctaatc catctaaact taaagcaagt gcaagtgtaa
     9481 atgcttcagc agatttaagc actttagatt tacttgtatc taagacatca ggttcgatac
     9541 ttacattaaa atttaattta aggtctaaca tattaaaatt ataattcttt gagtgtatag
     9601 attttttctt aaaataagat ttaaaaaaac tttcaattag tctagcactt cctaataaaa
     9661 ataaaataaa gaaacatatt aacattgtta tattttgagg taaaaaatct ctaactattg
     9721 tacctgcaaa aagcgatatt gctaaaatag ctgaacaaac tacgctgata attatatttg
     9781 aatataaggg aactttaact ttatttacac catatccaaa gcttgtcaca aaggcatcta
     9841 tacaaagaga agtaactaat aaaattgatt caatcacagt agattaacat cctttctctt
     9901 aaattttgta cttatattag ttatagtatt gtaaaaatgg ataaattgtt acagataatc
     9961 caataaattg ttgataaaat tccaacatca tacaacacct aaataacaaa agaatcatat
    10021 catataataa tataaaacca atcataataa agcgggtgaa aataatggaa caaaataata
    10081 aggttgggaa tttcggtgat ttgttgaaga ttttattaga tgaaaaagaa ttatcaatgg
    10141 gagaactaag taaaaaaagt ggaattgata aatctactat atctcgtata gctaataata
    10201 aacaaaagcc aaatataaat catttagaaa agatggcaat acatttaaat attaacctag
    10261 aagaactgtt gaaagcttca ggatatgaat ttagaaacag caataatcaa atatttaatg
    10321 cagatagtga ttttagtaac tttgatgata ttcttggatt tgcaaattta atcaatgata
    10381 agaactttaa tggaaatatt gaaaaagagt taagtaagtg taagttatat gtccaaacag
    10441 atgaaggtaa aaaattactt tttgataatt ttaataaaaa aatagattct attgaaaaac
    10501 aaggtcaatt tacagataga ttaagacaaa tgtatgctga tttttgtaca gatggactta
    10561 caataaagaa atatttattg attggaagta tgctacttta ctttgttata tcaacagatg
    10621 tgattccaga cttcgtgttc ccaataggat ttatggatga tttagtagca ttaaatatag
    10681 ttacaaaatt acttaaaaat gataagtaag ttttagaatc atatttaata tataaataaa
    10741 tcaaagtata taaaatttat tattttttat atgaaacaaa ttaaaagcac aatgaagtag
    10801 attaaaaatt taaaactaag aatctaatat atattttgta actatttaag tatataaaat
    10861 aaaataatat ccaaactaat acaaaatagt aataattgtt ttgtactgga ggatatatat
    10921 ttatgaattg taaatggata tctaaaatag atgagagaaa aaaatgtcat agagaagcag
    10981 attcttctgg atattgtatc tttcataaag aaaataagtc tgatgaagag atacagttga
    11041 tgatggatac tcttcataaa gaagagataa gtgaatttaa tggatttgtt tttgaaaatg
    11101 aatttaatgc ggaagaaata ttaacttaca attataaaat actggatttt tctgaatcca
    11161 tatttaaaca aaaagcaaat tttaaaaaat atatttttaa aaagaatatt atttttaact
    11221 atacagaatt tagagataaa gttttattta atggttgtgt attcttagaa aactgtgatt
    11281 ttaatagaac catatttagt aaacactata taaatgaccg tatatttgaa aaagtgaaat
    11341 ttaaaggacc tgatttggta gttaataaag tagaaaattt tccacgaatg gatggaataa
    11401 tttttagcat gtgtacaaaa tttgtgttaa agaatgttga atatggaaaa agtgagtatg
    11461 agcatggcaa gataaattat agaatagcta gaaatcaagc aacaaaaatt ggagaatatg
    11521 agatgatagg attttactat tataaggaaa gaatttatag tagtaaaata atgaaacgtt
    11581 ctaattatcc taccttcagt gattatttag ttgaaaaatt ttttgaccaa atagcacgtt
    11641 acacaacagg ttatggagaa aagccatgga atatattatt agttattata gcaataataa
    11701 gtgtttttgc tttattatac ttatttgtag gcatagaaag ttcaaatagc acacttgtag
    11761 ctttagatat aaataatata ggtgattact cactaagtga gattttcaaa atgtatatgg
    11821 atttatggta ttttagcatg gctacattta gtacagtagg atatggagat atggttgcta
    11881 caagtttgat tgggaaagca ttggcaggta tagaagtatt ttttggagtt acaataggag
    11941 caatttgggc atctgtgatt attaaaagaa tgataaggta atatttgtgt aaatatggat
    12001 aggtattaat tactagatat aaattggact aaatagggaa aatttaaata taaatatact
    12061 taataatcca agaaggtgaa aaatttgaaa aatgcactaa aaaaaattat atcattagcc
    12121 atgattctag tttttataat accaaattat tcatatgcag atgataaatc tgtagacaag
    12181 tattcaaaaa catctatact tatagaccaa gaaacaggta gagttttata tagtaaagaa
    12241 cctgatatga aggtaccatt agctagttta agtaagatga tgactttttt acttgcaata
    12301 gaagctattg aaaataaaga agtaaaagaa actgataagg taaaaataga caaatctatt
    12361 gcatcagtaa aagggtcaag ttataaactt aaagatggtg aagaagtgcc acttatagag
    12421 cttatgagag gtcttatgat tgtatcagga aatgatgcgg caattgctat agcaaaacat
    12481 gtttgtaaaa cgaaagaagc atttgtagat agaatgaata aaaaagcaaa agaaatagga
    12541 atgagtaata cacattttct aaatccaaat ggtcttccaa tatacgattt aagcaacccc
    12601 aaaaaaccag caaaagaaaa tatctctact gcaaaagata tagctattct tggaaaatac
    12661 atgtttgacc attatgaaaa acaagtaaca gctataactg atatggagac atatacaaat
    12721 tcagatagaa gttttgaaaa aagcaataca aatgcattat taagaattat accagaagta
    12781 gatggtataa aaactggata tactggcaat gctggatatt gcttatcatt ttctatggtt
    12841 gtaaataaaa atgataaaaa tgagaaaaaa cgtagagtaa taggggttgt attaggtact
    12901 aaccataaaa ataaaagaac ctctgcttca ttagctctac tgaaatatgg aaaagaaaat
    12961 ttcaatatga aaaaagtaat tgataaagat agctttattg gtaagaaata tataaaagga
    13021 acgaaagagt tagaggttac attaaaagca aaagatgaac tttatacaat attaaaagat
    13081 gatgaaagta taaagtcaga agttaagatt aaaaatatag agtaccctgt taaaaaaggt
    13141 gatactatgg gtattataaa atattatact aattcaggtg acttacttgg aagtgtagat
    13201 atagtaagta ataatagtat agataacgta tcattaaaaa caaaattaaa aatgaaattt
    13261 gcaaattaaa ttcaaaaaat ggtataaaat acacaaaaaa atataaaaat agaaaatatg
    13321 gaaaaaatat tgttatttct tcacctctgt gatatactac tagaggtgaa aaaataaaat
    13381 aaatcacaca cagcattggg atccttaaaa ggtgcctatt acatggtttt ttagggagaa
    13441 gatcaagctg gaggtataaa accaggaggt aagatatgtc agtaatatca atgaaacaat
    13501 tattagaagc aggtgttcac tttggtcacc aaacaagaag atggaaccct aaaatggcta
    13561 agtatatatt cacagagaga aatggaatat atataatcga cttacaaaaa acagttaaaa
    13621 aagttgaaga agcttacaag ttcactaaag aagtagctga aacaggaaag ccaatcttat
    13681 tcgtaggaac taaaaaacaa gctcaagatg cgataaaaga tgaagctgaa agatgtggaa
    13741 tgtactttgt taatgaaaga tggttaggtg gaatgttaac aaaccacaaa actataaaaa
    13801 caagaataaa taaattaaga gaattagaaa aaatggaaga agaaggcgta tttaatgttc
    13861 ttcctaaaaa agaagttata aaattaagag ctgaaaaaga aaaactagaa aaatacttag
    13921 gtggaataaa agacatgcct gaattaccag gtgcaatgtt cgtagttgac ccaagaaaag
    13981 aaaacatagc tattcaagaa gctcatagat taggtatacc agtagttggt atagttgata
    14041 ctaactgtga cccagaacaa ttagactttg ctataccagg aaatgatgac gctataagag
    14101 ccgtaaaatt aataactggt gctatggcaa cagctgtaat tgaaggtaga caaggtgctg
    14161 aggaagaagt agctgaagac caagaataat aatttgacaa ttaaatggta agggtcgccc
    14221 ttaccattta taatatggaa tagaataagt aggaggaaac ttaaaaaatg gctaatataa
    14281 ctgctcaaat ggtaaaagag ttaagagaaa gtacaggcgc aggaatgatg gactgcaaga
    14341 aagctttaca agaagctgaa ggaaacatgg aaaaagcagt agatttatta agagaaaaag
    14401 gattatcaaa agctgctaaa aaagctggta gagttgctgc tgaaggtcta gttgcaatag
    14461 aaatgaatga tgataataca gttgcttcta tggtagaagt taactcagag acagatttcg
    14521 ttgctaaaaa cgaagacttc aaagtgttcg ttaaagatgc tgcttgtatg gcattagcta
    14581 ctgataaaga agatatagct tctttattag gtgaaactca taaagaagga ataactttac
    14641 aagaagtttt aaataataga gttgcaaaaa taggtgagaa attagacttt agaagatttg
    14701 ctaaagttgt aactaatgga caagttgctg gatacattca cggtggtgga aaaataggtg
    14761 ttcttgttga aatggaaaca gaagctagag atgctaaagt tttagaatta ggtaaagatg
    14821 tagctatgca agttgctgct atgaatccta agtatgtttc aagagatgaa gtagatgctg
    14881 aatacatagc acatgaaaca gaagtattaa ctcaacaagc tttaaatgaa ggaaaaccag
    14941 ctaatatagt tgaaaaaatg gttaaaggaa gattagaaaa agaattaaaa gaggtttgtt
    15001 tattagagca aactttcgtt aaaaatccag atataactgt taaacaatta gttgctgatg
    15061 ttgctaaggc agtaggttct gatataaaag ttgttaaagt tgtgagattc gaagttggtg
    15121 aaggtataca aaagagagaa gaaaactttg cagaagaagt tgctaagcaa cttaagtaat
    15181 aaccaaagag agaacacgca ggtgttctct tttttaaaaa atagaaaaaa ttggatatga
    15241 aggattgaaa taggaggttt ctgatggata aaccaatgta caaaagggta ttgttaaaat
    15301 taagtggaga agcattagca ggagaaagag gttttggtat aaataatgat gtagttaatg
    15361 atattgctat tgctataaaa aaaatacaag aaataggtgt tgaagtagct gtagtagtag
    15421 gtggaggaaa cttctggaga ggcagaacca gtgaaggaat ggacagaact actgctgact
    15481 atataggaat gttagctaca gttatgaatg caatggcgct acaggatgca ctagaaaata
    15541 tagatgttgc tacaagagtt caaactgcta tagacatgag acaaattgca gaaccatata
    15601 taagaagaag agcagttaga cacttagaaa aggaaagagt tgttatattt ggtgcaggaa
    15661 caggaaaccc ttactttaca acagatacaa ctgctgcttt acgtgctgct gagatggaag
    15721 cagaagttat attgttagct aaaaatgttg atgcagtata tgacaaggat ccaaaagtac
    15781 atgcagatgc taagaaattt acagaattaa gttacatgga agttatacag aaagaattaa
    15841 aagtaatgga ttctacagct acatctttat gtatggataa taaaattcca ataaaggtat
    15901 ttgagcttac aacagagaat ataataagag cagtaaaagg cgaaaatata ggaactactg
    15961 taaaataatg aagaatgaag gaggagtaaa attatgaaac tggaaataca taagcaatta
    16021 gaagagaaaa tgaatgggac aattgatgct ttaaagtttg aatttggaac tataagagca
    16081 ggaagagcta atgcacaaat gctagacaaa ataagagttg attattatgg aactccaact
    16141 ccaataaatc aaataggtgc tatatctgta ccagaaccaa gaatattaat gatatctcct
    16201 tgggataaat ctgctatgca tgaaatagaa aaagcgatag ctaactcaga cttaggatta
    16261 aatccatcaa atgatggtga ggttataaga ctttctgtac ctgctttaac agaagaaaga
    16321 agaaaagaat tagctaaaaa agctagtaaa gctgcagaag aatttaaagt tagaataaga
    16381 aatgaaagaa gagacgccaa tgagaaaatt aaaaagatgg aaaaaggcgg agaattaact
    16441 gaagatgaat taaaaaaagc acaagatgaa gttcaaaaaa tgactgataa atttataaaa
    16501 gaaatagata cattattatc taaaaaagaa aaggacataa tggaggtata atattgaaaa
    16561 aatattataa ccttttaggt cttcatgtag atgaggtaaa acaatatttt gatgagcaaa
    16621 atataaatta taccgtaaaa tctattgaag gtaaaaagga taaagaaaaa cttgtagttc
    16681 ctagagttat aaaaatatct gagataggtg atagtgtaga actgataatc acatactttt
    16741 ctgactcctt agtttaagga gtcagaacaa tattggaggc aaaatatgaa taacaacatt
    16801 atatatgata tagacttaaa taacatacct actcatattg ctattataat ggatggaaat
    16861 ggaagatggg caaaagctag atttcttcca agaactgcag gacataaggc tggagtagaa
    16921 actataagag atatagtaaa agaatgctca aaattaggtg ttaagcactt aacattatat
    16981 gcattttcaa cagaaaactg gaaaagaccg aaacttgaag ttgacacact tatgaactta
    17041 ttatctacat acttaagaaa tgaaatagct gaacttcacc aaaacaatgt aaaagtaact
    17101 gctataggag atataagtgc tttaccaaaa acttgtataa gagaattaaa ctcagctaag
    17161 gaactgacaa aaaacaatac aggagttaac ttaaatttag cattaaacta cggaagtaga
    17221 gcagatataa aaaatgctct tatagatata gtaaaaaatt gtgaaagtgg taaaatagat
    17281 ataaacaata ttgatgaaga tattataaaa aactatttaa gcacaaagtc tataccagat
    17341 ccagacttgg taataagaac aagtggtgaa caaagattga gtaacttttt actttgggaa
    17401 gttgcttatt ctgagtttta ctttactgat atacattggc ctgattttaa aaaagaagaa
    17461 ctacagaagg ctatatacgt atatcaaaga agggatagaa gatttggagg acttaagtaa
    17521 ggagattatt ttatgcttac aagaattatt gcttcactag ctctggttcc attatttcta
    17581 tttgttgtat atggaggtat tcctctatat atagctgaga cagcaatagt ttatattgca
    17641 ttgcatgagt tttataaggc atttaaaata aaagatgtac atccaatatt cattatagga
    17701 tatttatttt ctatttattt agctgtaaaa aatattttta atttaccatt agaatatact
    17761 tatgcagtaa tttttatttt atttttagca agtataattt atatgttgat gggcaaaaac
    17821 aatgttatag atgtttcgat tacgttttta ggagtttttt atataggagt atttttagat
    17881 tttataatta taactataaa tggatttgaa aaaggtagta tatatgtatg gcttatattt
    17941 gtgatatctt ttatgacaga tatatttgca tattttagtg gttatttact tggaaaacat
    18001 aagctaattc ctaaagttag tcctaaaaag actatagaag gagctattgg aggaataata
    18061 ggaagtacac tttgttgtat tttatttgga tatttatttg gcattgattt gcttcaatta
    18121 gcgataatag gaagtatagg aagtgtaata gctcaattag gagatttatt tgcatcttct
    18181 ataaagagat atgtagggat aaaggattat ggaaagataa tacctggtca tgggggtata
    18241 ttagatagat ttgatagtgt tatattagtt gcaccttttg tatatagtgc gattaaattt
    18301 tttattagat aaagattggt tggatttaaa agagcaatct ataattgcta gtaatgaaaa
    18361 tagctatgta acttttaaat gcagagatat tctgcagtta ttagttacat ggctattttc
    18421 attgttcaaa aatttagaag accttgggga attgtataag aataggtatt actttataat
    18481 agtatactat atttgtagtg agtatatttt ttatactata actatcatta aaaaatattt
    18541 ttttgttt
//
LOCUS       DAEQCW010000075        18472 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.075, whole genome shotgun sequence.
ACCESSION   DAEQCW010000075 DAEQCW010000000
VERSION     DAEQCW010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18472)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18472)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18472
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.075"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            206..1399
                     /locus_tag="KRO40_002538"
     CDS             206..1399
                     /locus_tag="KRO40_002538"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase"
                     /protein_id="HBH2093355.1"
                     /translation="MDTLKELFKIGSGPSSSHTMGPQRAAERFKNENPDAESFRAILY
                     GSLAATGKGHLTDYIIEKTIAPKKVEIVWEEDIIKDFHPNGMKFEALDKDKNVTAEWT
                     VYSVGGGTIAEEGQRNSKSNSIYHLDTMDEIVKWCKENNKTLVDFVLECEPKDIKDYI
                     KTIKDAMRKSIDDGLSTDEIIPGKLLLKRRASTFYNAYKKDKSFSTLVYAYALAASEQ
                     NASGNIIVTAPTCGSAGVIPGIFFAMQDFYNYDDEKIIEALLVAGIIGNIIKTNASIS
                     GAEVGCQGEVGAACSMAAAAVAYLKGGTIDHIEYAAEIALEHHLGMTCDPVYGYVQIP
                     CIERNAMAAQRAYDAANYALLTDGSHSVSLDQVVETMKETGIDMMDKYKETAKGGLAK
                     HFFSC"
     gene            1605..2723
                     /locus_tag="KRO40_002539"
     CDS             1605..2723
                     /locus_tag="KRO40_002539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HBH2093356.1"
                     /translation="MREASYLQEQLYKHRKSLNPIAEIGRKEYKTSKYIRDYLDKLGI
                     EYEVYLETGIVGVIEGKRPKKDIAFRADIDGLHSEEGVKHLCGHDGHATILLGLIEYL
                     NDNKEDLNDNIVFIFQPAEEGPGGAKALIDEGVLRKYNIDEIYGLHIYPELPEGYVGT
                     REGYFMAQIGDIDIEIVSKSGHGAMPQNGIDGIVIASNFVSSLQTIVSRNISPIDNAV
                     LTIGRIEGGARRNIIAENIKMEGTMRCFSPEVYEKMKLRVRELARGFELAYNCKVNIN
                     IIDDYIAVKNDKDLYQEFVEAIGSDIVVELEPLMISEDFSYYQKEVPGLFFMLGSRNE
                     EKGFVNGLHNINFNFDEKICVNALNVYSKLLKYKEAID"
     gene            2854..3099
                     /locus_tag="KRO40_002540"
     CDS             2854..3099
                     /locus_tag="KRO40_002540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small, acid-soluble spore protein, alpha/beta
                     type"
                     /protein_id="HBH2093357.1"
                     /translation="MKEKVQREKKITNGKNTKILTNDDIMKYEIASELGLMDKVGERG
                     WAGLTAKEAGRIGGMLTSRKKRLKKIVEEQNKKDESI"
     gene            3086..3832
                     /locus_tag="KRO40_002541"
     CDS             3086..3832
                     /locus_tag="KRO40_002541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH2093358.1"
                     /translation="MSQYSDFAFVYDELMNEVDYNGWVKYIEDIIDSEGVKVKNILEL
                     ACGTGNLTIPLTKKNYDIAGIDISDEMLSVAREKAEKEGVELVLLQQDISELDFEISD
                     LDCVLCACDGFNYITYDDDLENIFSKTYELLKKDGIFIFDISSFYKLANILGNNMYGE
                     NREDIAYMWQNYFDEEENLIEMELTFFIKDECGKFERFEEIHQQRAYTEDEIVDMLEK
                     SGFKDIKYYGDFTFDKPSEESQRIFFVCKK"
     gene            4115..4990
                     /gene="hslO"
                     /locus_tag="KRO40_002542"
     CDS             4115..4990
                     /gene="hslO"
                     /locus_tag="KRO40_002542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HBH2093359.1"
                     /translation="MRDYVLRATSGNGQVRAFVATTRNTVEEARRLHETTKVATAALG
                     RTLTATSIMGLMMKNDSDKLTVIIKGGGPIGTIIATSDSKGMVKGYVGNPQVEVEDYP
                     NGKLNVAAAVGTEGVVKVIKDLGLREPYNGTYPLVSGEIAEDFTYYFAVSEQTPSVVA
                     LGVLTKEDEVEFAGGFIVQLMPDAEEETIAKLEENVAKLPSITNMLKEGKSPEDILNI
                     VLDGLEPKILDTCEVGFICECSKERVKTALVAIGKKSLAQIIEEDKKAEVGCQFCNKK
                     YMYSEEELLEILKEM"
     gene            5381..6181
                     /locus_tag="KRO40_002543"
     CDS             5381..6181
                     /locus_tag="KRO40_002543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH2093360.1"
                     /translation="MESKTKYIGISILILLMIFLIAKNFNGKLEIPIPESNSRKFKSA
                     AVFYPQHQDDEVLWGGSAIVDAIKQCGVDNVYVVLVSDGSGVNVFKANTKFRNLTRKQ
                     KEELRNNEFKSALRELGVKPQNVIILADIDKKEGTHYELMEKTILDFEHKFKGNVTHI
                     AHHYKYDDHIMHRKNGEVLKKLKREGKIKDDLYFVKPKYVKYIPRNERAIYKAMDFDD
                     YNKVKSACYEYKVVNSKRKMYGIGYISAHSYFEHLLNDPELTSVLSED"
     gene            6708..8948
                     /locus_tag="KRO40_002544"
     CDS             6708..8948
                     /locus_tag="KRO40_002544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBH2093361.1"
                     /translation="MNNEFIILKGCKENNLNNISLKIPKRKITIFTGVSGSGKSSIVF
                     ETIAKESQRQLNERFSTFVRSFLPKYGEVKADCIENLSTPIIIDQSRLGGNSRSTLGT
                     ITDVNSFLRALYSRFGSEYIGNANMFSFNNIDGMCPHCHGLGKKLVPNMNQILDMNKS
                     LNEGAILLSGFGVGSWHWNIFAESGFFDINKRICDYSEVELEKFLHGKAEKIKIENAG
                     QTNMTYEGLMVKFNRLYLSREGEISEATKKKLSKLLIEDRCPICDGRRLNERVYRSLI
                     NGYNIADLTSMQIDELAEVIKSIDEPEAQPLIKGIIEKLNSIIDIGLGYLTLDRETSS
                     LSGGESQRIKMVKYLNSNLVDLMYIFDEPSVGLHPKDVYKLNNLLKKLRDKGNTIIVV
                     EHDPDVIKIADHIVDVGPKAGKYGGEVVYEGSYENLLTSGTLTGNALSKFLPIKESVR
                     EHSGYLEVKNCNKNNLKNVSIKIPKGVLTLVTGVAGAGKSTLIKDEFLKQNPSAVLID
                     QSPVSANSRSSLATYSGIMNNIRSIFSKTNGVNASLFSSNSEGACDNCKGSGIVEMNL
                     AFMESIKSTCNVCEGKKFKKEVLEYRFQGKNIIEVLEMSVLEAIEFFNLKQIKTKLQC
                     IEKMGIGYLTLGQTLDTLSGGECQRLKLASELNKESSVYILDEPTTGLHMADIENFIS
                     IIEEIVDNGNTVIIIEHNIDVIKRADWIIELGPEGGTKGGRVIFEGIPKQLCNNKISL
                     TAKYIV"
     gene            9362..10897
                     /locus_tag="KRO40_002545"
     CDS             9362..10897
                     /locus_tag="KRO40_002545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH2093362.1"
                     /translation="MINDILTLLSERSDFFIKLSIEHLMISIISIIIAIVLGGIIGII
                     VSEFHNSSKPILGTINFLYTIPSISMLGFLIPFSGIGNTTAVIALTIYALLPMVRNTY
                     TGITNVDKNILEAARGMGSTDFQILYKIKLPLALPVIMSGIRNMVIMTIALAGIASFI
                     GAGGLGVAIYRGITTNNTIMTITGSILIALLALIFDFILGLVEKFFQRKRKKKNRKKV
                     FAILGSLILIATIFTSYLFNPSKTQTIHIATKPMTEQYILGEMLDILIEKNTGLNVEI
                     TQGVGGGTSNIQPAMENGEFDIYPEYTGTGWNMVLKKNELYTESMFSKLQSEYKTKLK
                     MQWTGMYGFSNSYALAVRKEVADKYNLKNITDLKDVSSKLTFGAEYDFYEREDGYTPL
                     CNTYGLNFKDTVDLDIGLKYQAINEGKIDVMPIFTTDGQYSVSDVVVLKDDKNFYPSY
                     QCGNVVRLEVLEENPELSKVFKMVGDILTDKEMAKMNYDVENNNLEPREVAREFLNKK
                     GLL"
     gene            10913..11674
                     /locus_tag="KRO40_002546"
     CDS             10913..11674
                     /locus_tag="KRO40_002546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093363.1"
                     /translation="MTPIIQFKNIKKQYNDKTIIDNLNLDIEKGEFLTVIGSSGSGKT
                     TLLKMINGLILPDGGNILINQTDIKNEDLIKLRRRIGYCVQGSVLFPHMTVEENISYV
                     PNLLSKKNKLEVKSAVNKWMEIVGLPNDMKVRYPSELSGGQQQRVGIARALASSPEIL
                     LMDEPFGAVDEITRKQLQKEIKEIHKKTGVTIIFITHDIYEALILGTKTLVLNHGVVQ
                     QYDTPENILNTPANQFVDQLLNIRKSIIDDDNLKE"
     gene            12012..12881
                     /locus_tag="KRO40_002547"
     CDS             12012..12881
                     /locus_tag="KRO40_002547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2093364.1"
                     /translation="MDNNLITIEKTLDYIEKHLLDEMLDLNVISKEIGYSKYHLHRMF
                     TSVVGFSVHNYIQRRRLTEAARMLIFTEKPIIEIALISGYDTQRSFSRGFKKMFKRSP
                     NFFRRHQDFLPLQLKFDIHNRKKLRGDMVLDVKKVNCADINIVGYSGKVRKGFHIIGK
                     CWRDLHKNKEMIENKVDLGFLIGVSDYSNFKEIENTPTFTYIAGAQVATFGKLPNGME
                     KFVLPKSNYIVFTFIGKNEDSMQNVVEYIYQEWFPNSSCQFNENNLYDFVKYGEKTDE
                     NGLSEIQFWVPII"
     gene            13210..13461
                     /locus_tag="KRO40_002548"
     CDS             13210..13461
                     /locus_tag="KRO40_002548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3781 domain-containing protein"
                     /protein_id="HBH2093365.1"
                     /translation="MNVENELLKNLDRLHTTELGVVRIKKNLSLETNDVVNWCKTKIE
                     SPNAIINRKGKNWYISVYDCIITVNAHSYTIITAHKEKK"
     gene            13573..14352
                     /locus_tag="KRO40_002549"
     CDS             13573..14352
                     /locus_tag="KRO40_002549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2093366.1"
                     /translation="MNDTVKEKLAESLTSDTTDILPYLPYLLQDFWELGSSPEQMLQL
                     FRKHIPFNEDTKVLDLACGKGAVSVKLAKELNIHIKGIDLIPEFIDYARRKAIEYKVD
                     ALCDFEMNDANSSVKIEHDYDCVIFGAVGDILGNYKETISKLLPTIKSKGFILIDDAY
                     VVDKSTNEQLNFERVYPTYNEWCILFKELGLKLIECIPCLELENDVEEEMNWIITRAN
                     ELIKKYPSQKDMFEQYVISQKNEYTDLQQDLVGATWILQKE"
     gene            complement(14487..15137)
                     /locus_tag="KRO40_002550"
     CDS             complement(14487..15137)
                     /locus_tag="KRO40_002550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093367.1"
                     /translation="MNIVMINGSPKVNKNNSQYFLSELKQLIQNDNKVFTFKVDNTSK
                     YPDALNAILNCDRLIIASPLYVDGIPSHLLHFLEKCEKFLKTQNKKPIPVYAIVNCGF
                     NEGEHNHLAIQMIEHWCKKINFTWVQGIGIGAGEMFGSLESVPLGKGPKKDLGIALKE
                     LSKNILSDNIHIDDSNKSTIFISPNFPRFLYKLMGNHQWNTQAKSNGLTKSDILKK"
     gene            complement(15134..15637)
                     /locus_tag="KRO40_002551"
     CDS             complement(15134..15637)
                     /locus_tag="KRO40_002551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2093368.1"
                     /translation="MRLLIHDLTDKELEKLLPKLDDNIKILPNTKEIHKCIGCFGCWI
                     KTPSECVVKDYYSNMGKLINDSDGIIIISRCCYGGFSPFVKNVLDKSINYILPYFVIK
                     DNMMRHKSRYDKQINLKAIFYGDCITEAEKETATKLVNGNAINFNIKEHSVCFYENIQ
                     DIRGESI"
     gene            complement(15686..16201)
                     /locus_tag="KRO40_002552"
     CDS             complement(15686..16201)
                     /locus_tag="KRO40_002552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH2093369.1"
                     /translation="MLEYIILGFLMEKELSGYDLKQIMSESTSYFFDASFGSIYPALK
                     RLETKGYIHYHEVIDGNKLKKLYSITNTGKEVFLEWLKKPINFSKTKQDHLVNIFFYK
                     YLPKEIIETNLKMLITEVELLLNKLSKQKNDAEENHCVDQYTYMYATMIYGVDYYNFV
                     INWCKDLLKNL"
     gene            16481..17005
                     /locus_tag="KRO40_002553"
     CDS             16481..17005
                     /locus_tag="KRO40_002553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2093370.1"
                     /translation="MHEQIDCCERKKRTIDIKGENMRELLKWVSIINRYNTNYIDRKL
                     ADIGINNSQYFYVLHICNNPGITQDTIFEKILVNPSNITRALANLEKEGFITREPGVK
                     DKRTWHLYPTEKSLGCYDEILKITNGYVEELLSSFEKEEQELFMSMLKKVAFLAIDMN
                     EEAKLEAKENGRKI"
     gene            16989..18392
                     /locus_tag="KRO40_002554"
     CDS             16989..18392
                     /locus_tag="KRO40_002554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093371.1"
                     /translation="MEEKYKEPLEYEKVSKLLTKYAIPSIIAMLVSALYNIVDQIFIG
                     QGVGVLGNAATNVTFPLTTICTAIALLLGIGGASKCSLELGAKNSEKATKAAGNSICL
                     MAVFGISLFIVVSIFLTPLLKFFGSTSEILPYAHTYTKITSIGLPFLIMSTGMSKLIL
                     ADGRPKASMFCMLIGAVINTILNPLFIFVFNMGIAGSALATVIGQLISFGISVHYIKN
                     FQHIKLHKKSFKLDSIIYKHIFALGSSSCFNQLAMTVTQIVMNNTLAYYGARSVYGSE
                     IPLACVGIIIKVNMIFISIIIGISQGMQPIIGYNYGAEKYNRVKEAYKFAVGSATIIS
                     VIAFLCFQLFPRQITSIFGNGNETYFIFAEHYFRTFLFLTFINGVQIVSSTFFTSIGK
                     SVLGLFTSLTRQILFLIPLIVILPMFMGIDGVMFAGPIADAAAAMVCIYFAVHEMKSL
                     TIKQNNLMSNHNKIAEV"
BASE COUNT         7059 a         1960 c         3349 g         6104 t
ORIGIN      
        1 tatattatat taatattaga aaaattttaa ataaatgttt tattctcaaa atatgcatat
       61 taatttaata aaatatacca aaatggaaat aaaaaataaa ttttatgaga atttaataac
      121 taataattaa tatatttagg ttataataaa tatgtgcgta aaatctaaca ataagcaata
      181 ataccgtaaa tttaggagga ataatatgga tactttaaag gaacttttta aaataggaag
      241 tggaccttca agttctcata ctatgggacc acaaagagca gcagagagat ttaagaatga
      301 aaacccagat gcagaaagtt ttagagcaat attatatggt agtttggcag ccacagggaa
      361 aggtcattta actgactata taattgaaaa aactatagca cctaaaaaag tcgaaattgt
      421 ttgggaagaa gatattataa aagattttca cccaaatggg atgaagtttg aagctttaga
      481 taaagataaa aatgtaacag ctgaatggac tgtatattct gtaggtggag ggactatagc
      541 agaagaaggc caaagaaaca gtaaaagcaa tagtatatat cacttagata ctatggatga
      601 gatagtaaaa tggtgcaaag aaaataataa gactttggta gattttgtgt tggaatgtga
      661 accaaaagac ataaaagatt atataaaaac tataaaagat gctatgagaa aatctattga
      721 tgatggacta agtacagatg aaataatacc aggcaagtta ttattaaaaa gaagagcaag
      781 tacattttat aatgcatata aaaaagataa gagcttctca acacttgtat atgcatatgc
      841 attagcagct tcagagcaaa acgcttctgg taatataata gttacagcac caacttgtgg
      901 ttctgctgga gtaataccag gaatattctt tgcaatgcag gatttctata attatgatga
      961 cgaaaaaata attgaagcac tacttgtagc tggaataata ggtaatataa taaaaactaa
     1021 cgcttcaata tctggagcag aggtagggtg tcaaggtgaa gttggagccg cttgttctat
     1081 ggcagcagca gcagtagcat acttaaaagg tggaactata gaccatattg aatatgcggc
     1141 agaaatagca cttgaacatc atttaggaat gacttgtgac cctgtatatg gatatgttca
     1201 aattccatgt atagaaagaa atgcaatggc agctcaaaga gcttatgatg cagctaatta
     1261 tgcattatta actgatggct cacattctgt ctccttagac caagttgttg aaacaatgaa
     1321 agaaactggt atagatatga tggataagta caaagaaaca gctaagggtg gacttgctaa
     1381 acatttcttc tcttgctaaa aataaaattt tccaataata attcctctgt tttgatttat
     1441 gaaacagggg aattattatt aatggtgaat tatttaataa tgcaaaatat ttttatattc
     1501 aatttagctt tttattttta attagtataa catgctatat aatattttaa ttataaagaa
     1561 atatagaaat attttttaat aaattagaaa ttggaggaga ttacatgaga gaggcatcat
     1621 atttacaaga acaactttat aaacatagga agtcattaaa tcctattgca gagattggga
     1681 gaaaagagta taagacttca aaatatataa gagattatct tgataaatta ggaattgagt
     1741 atgaagttta tttagaaaca ggtatagtag gtgtaataga aggtaaaaga cctaaaaaag
     1801 atattgcttt tagagctgac atagatggtc ttcatagtga agaaggggta aaacatttat
     1861 gtggtcatga tggacatgct actatattac ttggattaat tgagtattta aatgataata
     1921 aagaagactt aaatgataat atagtattta tattccaacc agcagaagaa ggtcctgggg
     1981 gagcaaaagc tttaatagat gaaggagtgc ttagaaaata caatattgat gaaatatatg
     2041 ggcttcatat atatccagag ttaccagaag gttatgtagg tacaagagag ggctatttta
     2101 tggctcaaat aggagatatt gacatagaaa tagtgtctaa aagtggacat ggggctatgc
     2161 cacaaaatgg tattgatggt atagtgatag cttcaaactt tgtaagctca cttcaaacta
     2221 tagtgtctag aaatataagc ccaatagaca atgcagtgtt gactattggt agaattgaag
     2281 ggggagctag aagaaatata atagctgaaa atataaagat ggaaggtact atgagatgtt
     2341 tcagcccaga agtgtatgag aaaatgaagc ttagagttag agaacttgct agagggtttg
     2401 aattggctta taactgtaag gttaatataa atattataga tgattatatt gctgttaaaa
     2461 atgacaagga tttgtatcaa gagtttgtag aggctattgg aagtgatatt gttgtagagt
     2521 tagagccact tatgatatca gaagattttt cttattatca aaaagaagtt ccaggattat
     2581 tttttatgtt gggttcaaga aacgaagaaa aaggatttgt aaatggtctt cataatataa
     2641 actttaattt tgatgaaaag atatgtgtaa atgcattgaa tgtttattca aaattattaa
     2701 aatacaaaga agcaatagat taggaagata agttataaag attaaaaagc ataaatacct
     2761 aaatttaaaa aaagtgtatt aataaatacc ccttacatat ttgtataaat ttattttaat
     2821 tgacaaaaat acaaataaga aggggtgatt tttttgaaag aaaaagtaca aagagaaaag
     2881 aagataacta atggcaagaa tactaaaata ttgacaaatg atgatataat gaaatatgag
     2941 atagcctcag aactaggtct tatggataaa gttggtgaac gtggatgggc aggacttaca
     3001 gctaaggaag caggaagaat tggaggtatg cttacatcac gcaaaaagag gcttaaaaag
     3061 attgtggagg agcagaataa aaaggatgag tcaatatagt gattttgcgt ttgtatatga
     3121 tgaacttatg aatgaagttg attataatgg ttgggttaaa tatatagaag atataataga
     3181 tagtgaaggt gtaaaagtaa aaaatatatt ggaattggca tgtggcacgg gtaatcttac
     3241 aattccattg actaaaaaaa attacgatat agctggtata gatatatctg atgagatgct
     3301 tagtgtagca agagaaaagg cagaaaaaga aggagtagaa ttagttttac ttcaacaaga
     3361 tatatcagag cttgattttg aaatatctga tttggactgt gtactttgtg cttgtgatgg
     3421 atttaattat ataacttatg atgatgattt ggaaaatata ttttcaaaga catatgaatt
     3481 attaaagaaa gatggaatat tcatatttga tataagttct ttttataaat tagccaacat
     3541 attgggaaat aacatgtatg gagaaaatag agaagatata gcgtatatgt ggcaaaatta
     3601 ctttgatgaa gaagagaatc taattgaaat ggaacttaca ttctttatta aagatgaatg
     3661 tggaaagttt gaaagatttg aagagataca ccaacaaaga gcatatactg aagatgagat
     3721 agttgatatg cttgaaaaat ctggatttaa ggatataaaa tattatgggg attttacatt
     3781 tgacaaacct agtgaagaaa gtcaaagaat cttctttgta tgtaaaaaat aagatattct
     3841 tgactatata agataattat taaaaataac catgatataa aaatatagaa aatgcagttt
     3901 tatagattaa aagtaaagtg atgatacttt atgactttta ttttttaata attataaagt
     3961 tctatagata aaaattaaaa tatagtaact attacttagt aaaattaaaa taaaatgggt
     4021 tttgcccaag gttaagatag ataagtattt atagataaat taaggtagta atataataaa
     4081 aataagacaa ttaacgggac atggaggaat attaatgaga gattatgtac taagagcgac
     4141 atcaggaaat ggtcaagtta gagcatttgt cgcaactact agaaatacag tagaagaagc
     4201 tagaagatta catgaaacta caaaagtagc aacagcagca cttggaagaa cattaacagc
     4261 cacatctata atgggattaa tgatgaaaaa tgatagtgat aaattgactg taataataaa
     4321 aggtggaggt ccaattggaa ctattatcgc cacatcagat tctaagggaa tggtaaaagg
     4381 atatgtagga aatccacaag tagaggttga agactatcca aatggaaagt taaatgtagc
     4441 agcagcagta ggtacagaag gtgttgtaaa agttataaaa gatttaggtc ttagagaacc
     4501 atataatggg acttatccat tggtaagtgg agaaattgca gaagacttta cttattattt
     4561 tgctgtatca gagcagactc catcagtagt agctttaggt gttcttacaa aagaagatga
     4621 agtagagttt gctggaggat ttatagttca attaatgcca gatgcagaag aagagactat
     4681 tgctaagtta gaggaaaatg tagctaaatt accttctata actaacatgt taaaagaagg
     4741 aaaatcacca gaggatatat taaatattgt tttggatggt ttggaaccta aaatacttga
     4801 tacctgtgaa gttgggttta tatgtgaatg ttcaaaagaa agagtaaaaa ctgctttggt
     4861 tgcaattggt aaaaaatcat tggctcaaat aatagaagaa gataaaaaag cagaagttgg
     4921 ttgccagttc tgtaataaga agtatatgta tagtgaagaa gagttgcttg aaattttaaa
     4981 ggaaatgtag actataaaaa tagttgtatt gatataagta atgttatagt gatatagtaa
     5041 agtcgtattg atatagtaat taaagtataa tttattaata atagacgtat ttatattaaa
     5101 aaataagttt aataaatttt taagcttaat aaattttaag aattaagaag ctttctggct
     5161 gtaatgtttg caatgttgca gttagaaggc ttttttattt tattatagtt cgtgtcaaag
     5221 attgtatgaa acaataaaat attgtaaaat aatttgtata tttagacctg attggcacaa
     5281 aggtttataa ggtatttgag ttgattatgc gaaattctat gaagtagtaa ccctgtgact
     5341 ttaatcatgg gaggttcaga agaaggagaa aattttaaat atggaaagta aaacgaagta
     5401 cataggaata agtatattaa tattattgat gatattttta attgcaaaga attttaacgg
     5461 aaaacttgaa atacctattc ctgagagtaa tagtagaaaa tttaaatcag cagcagtgtt
     5521 ttatcctcaa catcaagatg atgaggtttt atggggagga agtgccattg tagatgctat
     5581 aaaacagtgt ggtgttgata atgtatatgt ggtattagta tcagatggtt ctggagttaa
     5641 cgttttcaaa gctaacacaa aatttagaaa tttaactagg aagcaaaagg aagagcttag
     5701 aaataacgag tttaaatcag ctttgagaga gcttggagtg aaacctcaaa atgtgattat
     5761 acttgcagat atagataaaa aggaaggcac acattatgaa ttaatggaaa agactatatt
     5821 ggattttgaa cataagttta aaggcaatgt gacccatata gcccatcact ataagtatga
     5881 tgaccatata atgcatagaa agaatgggga agttttaaag aaacttaaac gtgaaggtaa
     5941 gataaaagat gacttgtatt ttgttaagcc aaaatatgta aagtatatac caagaaatga
     6001 aagagctatc tataaagcaa tggattttga tgactacaat aaggttaaga gtgcttgtta
     6061 tgaatataag gttgtaaatt caaagcgtaa aatgtatggt ataggatata tttcggcaca
     6121 tagttatttt gaacatcttc taaatgaccc tgaacttacg tctgtattaa gtgaagatta
     6181 atttcttata agtagtaagt tatgtttgat aagttgattg gaattttcta tagttttgaa
     6241 ggtattggaa atttagtttt atttaaagat ttaaagatag aggtttttag tgtttaaaat
     6301 tttaaagtta agttgaataa ttgtatagaa ttatttgtga aagaagaaac agtgtaaaac
     6361 atagtatctt atttatggtt ttaaaatcat aggcaagata ctttttttat gtaactaata
     6421 ccattttgag attattaact taagaatttt atataattta acactcatat ataatgatga
     6481 tatttaggta gaatagatgc aattacgctt aaataaaata actgtatttt ttataaaaat
     6541 caaaccctac actatactac cagataaaat ctacatgcta taatttgacc tgtgtttata
     6601 aaaaaaggag taatctaata aaatagtatt tcacttatgt ataactaaca actattatta
     6661 cgattttctc taaataattt aaagaaaaat aatgcaggag gtaaaatatg aacaatgaat
     6721 ttataatttt aaaaggttgc aaagagaaca atttgaacaa tatttcctta aaaataccaa
     6781 aaagaaaaat aaccatattc acaggggtgt cgggttctgg aaagtcatct attgtatttg
     6841 agacaattgc aaaagaatca caacgccaac taaatgaaag gtttagtaca tttgtaagaa
     6901 gttttttacc taagtatgga gaggttaaag ctgattgtat agaaaatttg tcaacaccaa
     6961 ttatcataga ccaaagtaga cttggtggaa attcaaggtc aaccctaggt actattacag
     7021 atgtaaattc ctttttaaga gctttatatt caaggtttgg tagtgagtat ataggtaatg
     7081 ctaatatgtt ttcttttaat aatattgatg gtatgtgccc acactgtcat gggcttggaa
     7141 aaaagctagt tcctaatatg aaccaaattc ttgatatgaa taaatcatta aatgaaggtg
     7201 ctatattgct ttcagggttt ggagtgggtt cttggcattg gaatatattc gctgaatcag
     7261 gattttttga tattaataag aggatatgtg attattcaga agtagaattg gaaaagtttt
     7321 tgcatggtaa agcagaaaag attaagatag aaaatgctgg tcaaactaac atgacatatg
     7381 agggattaat ggttaaattt aatcgcctat acttaagtag agagggagaa atatctgaag
     7441 ctactaagaa aaaattgagt aaacttctta tagaagatag atgtcctata tgtgatggaa
     7501 gaagacttaa tgaaagagta tataggtctt taattaatgg ttataatata gcagatttaa
     7561 ctagtatgca aattgatgaa ttggctgaag ttattaaaag tatagatgag ccagaagcac
     7621 aacctttaat taaaggaata atagaaaagt taaacagtat catagatata ggtcttggat
     7681 atttaacact ggatagagag acatcttctc tatcaggagg ggaatctcag cgtataaaga
     7741 tggttaagta tttaaatagt aatcttgttg atttaatgta tatttttgat gaaccaagtg
     7801 taggacttca tccaaaagat gtgtataaat taaataatct tttaaaaaaa ttgcgtgata
     7861 aagggaatac aattatagtt gttgaacatg acccagatgt tattaagatt gcagaccata
     7921 ttgtagatgt aggaccaaag gcaggtaagt atggtggaga agttgtgtat gaaggcagtt
     7981 atgaaaatct acttacaagt ggtactttga cagggaatgc tttaagtaaa tttcttccta
     8041 ttaaagaaag tgtaagagaa catagtggat atttagaagt taaaaattgt aataaaaaca
     8101 atttaaaaaa tgtatcgatt aagataccta aaggtgtatt gactctagtt actggagtag
     8161 caggagcagg taaaagtacg ttgattaagg atgaattttt aaagcaaaat cctagtgctg
     8221 tacttataga ccaaagccct gtttcagcaa attcaaggtc gagtttggca acatatagtg
     8281 gaattatgaa caacataaga agcatatttt caaaaacaaa tggcgtaaat gcttctttat
     8341 tcagttcaaa ttcagaagga gcttgtgata actgtaaggg ttctggaata gtagaaatga
     8401 atcttgcttt tatggagagt ataaagagta cctgcaatgt ttgtgaaggt aaaaaattta
     8461 aaaaagaagt tttagaatat aggtttcaag ggaagaatat aattgaagtt cttgaaatgt
     8521 ctgttttaga ggcaattgag ttttttaatt taaaacagat taaaacgaaa ttacaatgta
     8581 ttgaaaaaat gggtattgga taccttactt taggacaaac tcttgatact ttgtctggag
     8641 gagagtgtca aagattaaag cttgctagtg aattaaataa ggaaagttca gtgtatatat
     8701 tagatgaacc aacaacaggt cttcatatgg ctgatattga gaattttata agtataattg
     8761 aagagattgt agataatgga aatacggtca taataattga acacaatata gatgtaatta
     8821 aaagagctga ttggattatt gagctgggac ctgaaggagg aacaaaaggc gggagagtaa
     8881 tatttgaagg tattccaaaa caattatgta acaataaaat atcattaaca gcaaaatata
     8941 tagtataata aataaaatat aataaaatta taatgatatt ttaataaata taatgggtat
     9001 ataaaatgat aattaaactt aacagtaata aataatgtga gaaatattca aatttaatta
     9061 aataaagtgt cagaaatttg tttaaatttt agtattttaa cggttctgac cttttttctt
     9121 atttttatgg agaatatcga ggatggagtc tctaatagtt acttttttgt gtctacttgc
     9181 aagtttgatt aaaaaatggc tatacacact tgtgacttca gtcatgggag gttcagatta
     9241 taatcttaat atataatttg tgaaataatt tgatgacgat ttgctgatgt ataaacaata
     9301 aagattaact acattaaaat ttaaatcttg ttaagtaaaa cttataaaag gagagagatg
     9361 gatgataaat gatattctaa ccttattatc tgaaagaagt gattttttta taaagctatc
     9421 catagaacat ttgatgattt ctattatttc tataataatt gcgattgttt tgggtggtat
     9481 aattggtatt attgtaagtg aatttcataa ttcttctaaa cctatattgg gaactatcaa
     9541 ttttctatac accattccat ctatttctat gctaggattt ctgataccat tttccggaat
     9601 tggaaatact actgctgtta ttgcacttac catttatgca ttattgccaa tggttagaaa
     9661 tacatatact ggaattacta atgtggataa aaatattctt gaagcagcta ggggaatggg
     9721 aagtacagat tttcagatat tgtataaaat aaaacttccg ttagccctac ctgttattat
     9781 gtctggtatt agaaatatgg tgattatgac aattgcatta gctggtatcg cttcatttat
     9841 aggtgctgga ggtctaggtg tagccatata tagaggaatc acgacaaata acacaataat
     9901 gacaattact ggaagtatac ttattgctct attagcttta atatttgatt ttattttagg
     9961 gctggtagaa aaattttttc aacgaaaaag aaaaaagaaa aataggaaaa aagtttttgc
    10021 cattctagga agccttattc ttatagcaac tatctttacg tcttatttat ttaatccttc
    10081 aaagactcaa actattcata ttgctactaa acctatgact gaacaatata ttcttggtga
    10141 gatgttggat attttaattg aaaaaaacac aggtctaaac gtggaaatta cacaaggtgt
    10201 aggaggggga acatctaata tccagccagc tatggagaat ggagaatttg acatttatcc
    10261 agagtataca ggtacaggct ggaatatggt acttaagaaa aatgaattat atactgaaag
    10321 tatgtttagt aaactacagt cggaatacaa aactaaactt aaaatgcaat ggactggtat
    10381 gtatggtttt tctaatagct atgcattagc agttagaaaa gaagttgcag ataaatacaa
    10441 tttaaaaaat ataacggact taaaagatgt atcttctaaa ttgacatttg gagctgaata
    10501 tgacttttat gagagagagg atggatatac tccattgtgt aatacatatg gactgaactt
    10561 taaagataca gttgatttag atattggatt aaaataccaa gctatcaatg aaggtaagat
    10621 tgacgtaatg cctatattta caactgatgg tcagtatagt gtttcagatg ttgtagttct
    10681 aaaagatgat aaaaatttct acccatctta tcaatgtgga aatgttgttc gtttggaagt
    10741 attagaggaa aatccagaac tatcaaaggt atttaagatg gttggagata ttttgactga
    10801 taaagaaatg gctaaaatga attatgacgt agaaaacaac aatttagaac ctagagaagt
    10861 tgctcgtgag tttctgaata agaaaggtct tttataaatt ggaggaaata taatgacacc
    10921 tattatacaa tttaaaaata ttaaaaaaca atataatgat aaaactataa tagataatct
    10981 taatttagat atagaaaaag gagagttttt gactgtaatt ggttcgtctg gttctggtaa
    11041 gacaacactc ttaaaaatga ttaatggtct gattttgcca gatggaggaa atattttgat
    11101 aaaccaaaca gatatcaaaa acgaggactt aattaaatta agaagaagaa taggatattg
    11161 tgtacaggga agtgttcttt ttcctcatat gactgttgaa gaaaatattt catatgtacc
    11221 aaatctccta agtaaaaaga ataaattaga agtaaaaagt gctgtaaaca agtggatgga
    11281 aatagtggga ttgccaaatg atatgaaagt gcgttaccca tcagaattgt caggtggtca
    11341 gcaacaacgt gtagggattg caagagcttt agcttcttct ccagaaattt tattaatgga
    11401 tgaacctttt ggtgcagttg atgagattac acgaaagcaa ttacaaaaag agataaaaga
    11461 aattcataaa aaaacaggag ttacaattat ctttattacg catgatattt atgaagcttt
    11521 gattttggga acaaagactt tggtattaaa tcatggagtt gttcaacagt atgatactcc
    11581 tgagaatatt ttaaatactc ctgctaacca atttgtagac cagttattga atataagaaa
    11641 atctataata gatgatgata atttaaaaga ataaatttaa atttaaaatc aaattgttgt
    11701 gataaaaact attgatttag agctaacttc aagttgtata cttgaagtgg aaaagttaga
    11761 ttaaggtata gaagggcatt tagcagttgg ctgtagacga ggtaactgct gaaggtgctt
    11821 tcaataaatg gctagaacct gtatctgttg aagattataa taaattgaaa taagaagctc
    11881 aatatacaga gtagataggc acttcaaata gaagtgtctt ttgtgtgcca taaaataaat
    11941 caaaatatta gcaaagaatg tgaaaaacaa aataaaataa tatgctatct ttaaaatagg
    12001 agggatgcta tatggataac aatttgatta ccattgaaaa aactttagat tatatagaaa
    12061 aacatctttt agatgagatg ttagatttaa atgtaatttc taaagagata ggctattcaa
    12121 aataccattt acatagaatg tttacatcag ttgtcggatt tagtgtacat aattatatac
    12181 aaagacgtag acttactgaa gcagcgagaa tgctaatttt tacagaaaaa ccaattattg
    12241 agattgcttt aatctcgggg tatgatacac aacgctcttt ttcaagaggg tttaaaaaaa
    12301 tgtttaaacg tagtcctaat ttttttagaa gacatcaaga ttttttacca ctacaattaa
    12361 aatttgatat tcataataga aaaaaattac gtggagatat ggttttagat gttaaaaaag
    12421 ttaattgtgc agatataaat attgttggct attctggtaa agtaagaaaa ggatttcata
    12481 ttattggaaa atgctggagg gatttgcata aaaataaaga gatgatagaa aataaggtag
    12541 atttaggttt tttaattgga gttagtgatt atagcaattt taaagagatt gagaatactc
    12601 ctacatttac atacattgca ggtgctcaag tagctacttt tggcaaatta cctaatggaa
    12661 tggaaaaatt cgtattaccg aaaagtaatt atattgtttt tacttttatt gggaaaaatg
    12721 aggatagtat gcaaaatgtt gtagaatata tctatcaaga atggttccct aattcaagtt
    12781 gccagtttaa tgaaaataat ttatatgact ttgtaaaata tggagaaaaa actgatgaga
    12841 atggtttgag tgaaattcag ttttgggttc caatcattta aaagaaggta ttatgtataa
    12901 agtagatgga tttatatagg caaagtttta cagcagtatg tatttataaa taatttatag
    12961 tttgtaggaa agaaataatt ttactataag attatgataa aatacacaat actatgacaa
    13021 aatagtgtta aataatagat ttaattttgc ataggaaaag ttctataatg gtgtgtattc
    13081 ataaataatt tataatctgt aggaaagaaa tagttttact ataagattat gataaaatac
    13141 acaatactat gataaaatag tactaaataa tagatttaat tttgcaaagg ataaagtgtt
    13201 ttaataaaaa tgaatgtaga aaacgaatta cttaaaaacc tagatagatt gcatacaaca
    13261 gagttaggcg ttgtaagaat taagaaaaat ctttctttgg agacaaatga tgtagtgaac
    13321 tggtgtaaaa ctaaaataga atctccaaat gccattatta atagaaaggg aaaaaactgg
    13381 tatataagtg tatatgattg tattataaca gtaaacgctc acagttatac aattattaca
    13441 gctcataaag aaaagaaatg aattgcaaaa tacaaaggtc aaaagcattt tccactgttt
    13501 gtagtaccta tgaagaagta tataaaataa tattactttt gaataataat ttaaattttg
    13561 gaggttgaaa aaatgaatga tactgtaaaa gaaaaattgg cagagtcact aacttctgat
    13621 actactgata ttttacctta tttgccttat ttattacaag atttttggga attaggaagt
    13681 tcaccagaac aaatgttaca attatttaga aagcatatac cttttaatga ggatacaaaa
    13741 gttttggatt tagcttgtgg aaaaggtgct gtatctgtga agcttgcaaa agagttgaat
    13801 atacatatca aaggtattga tttgatacct gaatttattg attatgctag aagaaaggct
    13861 attgaatata aggttgatgc tttgtgtgat tttgaaatga atgatgctaa tagttctgta
    13921 aaaattgagc atgattatga ttgtgtgatt tttggagctg taggggatat tttaggtaat
    13981 tataaagaaa ctataagtaa gctattacct acaataaaaa gtaaggggtt cattttaatt
    14041 gatgatgcat atgtagtaga taaatctaca aatgaacagc ttaattttga gagggtgtat
    14101 cccacttaca atgagtggtg tatattgttc aaagaattag gtctgaagct aattgaatgt
    14161 ataccatgtt tagaacttga aaatgatgtt gaagaggaaa tgaattggat tataactcgt
    14221 gcaaatgagc taattaaaaa atatccttct caaaaagata tgtttgaaca atatgttatt
    14281 agccaaaaaa atgaatatac tgatttacag caggaccttg ttggagcaac ttggatttta
    14341 caaaaagaat aagataaata ttagactaga taatcaatgt tatagtgaat tatcccatgt
    14401 ctagtgaata taaataacat aaaaaaccgt caagatgaat agtttattcg tgcttgacgg
    14461 tttttagtat ttgttgaagt aaaattttat ttctttagta tatcactttt agtcaatcca
    14521 tttgatttag cttgagtatt ccattgatga ttccccataa gtttatatag gaatctaggg
    14581 aagttaggtg aaataaaaat agtacttttg ttggaatcat ctatatgtat attatcacta
    14641 agtatatttt ttgaaagttc ttttaatgca attcctaaat cttttttagg tcctttaccc
    14701 aaaggtacgg attctagtga accaaacatc tccccagctc caattccaat accttgaacc
    14761 catgtaaagt tgattttttt acaccaatgc tctatcattt gaattgccaa atgattatgt
    14821 tcaccttcat tgaatccaca gttaactatt gcatacactg gaataggttt tttattttgt
    14881 gtttttaaaa atttttcaca tttctctaaa aaatgaagta aatgagatgg aataccatct
    14941 acataaagag gagatgcgat tattaatcta tcacaattaa gtatggcatt aagagcgtca
    15001 ggatacttag atgtgttatc tactttaaat gtaaaaactt tattatcatt ttgaataagt
    15061 tgttttaatt cagataaaaa atactgtgaa ttatttttat ttacttttgg actaccattt
    15121 atcattacta tattcatatg gattcacctc ttatatcttg tatattttca tagaaacaaa
    15181 cagagtgttc ttttatattg aaatttatag catttccatt tactaatttc gtagcagttt
    15241 ctttttcagc ttctgtaata caatctccat agaatatagc ttttaaattt atctgtttat
    15301 catatctgct tttatgacgc atcatattat cttttattac aaagtatgga agaatataat
    15361 taatgctttt atcaagtacg tttttgacaa aagggctaaa ccctccgtaa cagcatctgc
    15421 ttattataat aattccatca gagtcattta taagtttacc catgttgctg taataatctt
    15481 ttacaacaca ttcagaagga gttttaatcc agcaaccaaa acaaccaata catttgtgga
    15541 tttcttttgt gtttggaagt atttttatat tgtcatcaag tttgggtaat aacttttcta
    15601 attctttgtc agttaaatca tgtattaaaa gcctcataaa gtccatctcc ttttattatg
    15661 tatgtttact tctaaaaatt atatcttata gatttttcag taaatcttta caccaattaa
    15721 taacaaaatt ataatagtca actccataaa tcattgttgc atacatatat gtatattggt
    15781 caacacaatg attttcttct gcatcatttt tttgtttact taatttattt agaagtaatt
    15841 ctacttcagt tattaacatt tttaagtttg tttcaattat ttctttgggt agatacttgt
    15901 aaaagaatat attaacaagg tggtcttgct ttgttttaga aaaatttata ggtttcttta
    15961 accattcaag aaatacttct ttaccagtat tagttatgga atatagtttt tttaatttgt
    16021 taccatctat aacttcgtga tagtgtatat atccttttgt ttctaatctt ttaagtgcag
    16081 gatagatact tccaaagctg gcgtcaaaaa agtacgaggt actttctgac attatttgtt
    16141 ttaagtcgta tccacttaat tctttttcca ttaaaaatcc taaaataatg tattctaaca
    16201 tattacctcc tggtatcaat tagatatata tcgattcgat atatttatta ttacagataa
    16261 taaatcttac gtcaagatgc tttttaagat aagctaaaaa gaattaggag ttattgataa
    16321 atatgcaaaa aaattaatat aaaaggtaat taaatatcaa taaagattta aaaatagtta
    16381 aatcaaagta agagtctaat atataaaatt tatagtaact ttatggttta aatataaact
    16441 tgtgtgctat tgacaaagta taaaattagc agtagaataa ttgcatgagc aaatagattg
    16501 ttgcgaacgc aaaaaaagga caatagatat taaaggagag aatatgagag agctattaaa
    16561 atgggtttcc attataaata gatacaatac aaattatatt gacaggaaat tggcggatat
    16621 tggaatcaat aatagccaat atttttatgt attacacata tgtaataatc caggtattac
    16681 acaggacact atatttgaga aaattcttgt gaatcctagt aatataacaa gagctttggc
    16741 aaatttagaa aaagaaggct ttataacaag agaaccaggt gtaaaggata aaagaacatg
    16801 gcatttatat cctacagaaa aatctttagg atgttatgat gaaatactaa aaataacaaa
    16861 tgggtatgtt gaggagttgt tgagttcatt tgagaaagaa gagcaagagt tgtttatgtc
    16921 aatgttaaag aaagttgcat ttttggctat tgatatgaat gaagaagcaa aattggaggc
    16981 gaaggaaaat ggaagaaaaa tataaggagc cattggaata tgaaaaggtt tcaaagttat
    17041 taactaagta cgcaattcct agtattatag caatgttagt aagtgcttta tataacattg
    17101 ttgaccaaat atttattggg caaggtgttg gtgtattggg caatgctgct acaaatgtca
    17161 cttttccact aacaacaata tgtactgcaa ttgcattatt gttaggaatt ggaggagcgt
    17221 ctaagtgttc attggaatta ggtgctaaaa attcagaaaa agctacaaaa gcagcaggaa
    17281 attctatatg cttgatggct gtttttggaa taagtttatt tatagtagta tcaatatttt
    17341 taacaccact attaaaattc tttggctcta catcagaaat actaccttat gcacacacat
    17401 atacaaaaat tacatcaatt ggattaccat ttcttataat gtccactgga atgagtaagt
    17461 tgatacttgc agatgggaga ccgaaagctt ctatgttttg tatgttaata ggagcagtta
    17521 ttaatacaat tttgaatcca ttattcattt ttgtttttaa tatgggaatt gctgggtctg
    17581 ctttagcaac tgttattggg caacttatat cttttggaat aagtgttcat tatataaaga
    17641 attttcaaca tattaaatta cataagaaaa gttttaaatt agatagtata atttataaac
    17701 atatatttgc gctaggttca agctcatgtt ttaatcaatt agcaatgact gtaacacaga
    17761 tagttatgaa taatacattg gcatattatg gggctaggtc agtttatgga agtgagattc
    17821 cacttgcttg tgtcggtatc attattaaag taaatatgat ttttatatct ataattattg
    17881 gtatatcaca aggtatgcaa ccaattatag ggtataatta tggggctgaa aagtataatc
    17941 gtgtaaaaga agcatataag tttgcagtgg gaagtgcaac tattatatct gttattgcat
    18001 tcttatgttt ccaattattc ccaagacaaa ttacgtctat atttggtaac ggaaatgaga
    18061 cttattttat atttgcagaa cattatttta gaactttctt gttcttaaca tttataaatg
    18121 gtgttcaaat agtatcatca actttcttta catcaattgg gaaatcagtg ttgggacttt
    18181 ttacttcttt gactcgtcaa attttatttt taattccatt gatagtaatt ttaccaatgt
    18241 ttatgggaat tgatggagta atgtttgcag gaccaatagc agatgcagca gcggcaatgg
    18301 tatgtatata ctttgcagtt catgaaatga aatcattgac tataaagcaa aataatttga
    18361 tgagtaacca taataagatt gcagaggtat aagacaatat ttaagaagta tagaaaatta
    18421 atttaaagaa gtataataaa ctaatttagg aagtatagaa aattaatcta aa
//
LOCUS       DAEQCW010000076        18348 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.076, whole genome shotgun sequence.
ACCESSION   DAEQCW010000076 DAEQCW010000000
VERSION     DAEQCW010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18348)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18348)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18348
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.076"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            326..1363
                     /locus_tag="KRO40_002555"
     CDS             326..1363
                     /locus_tag="KRO40_002555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093372.1"
                     /translation="MLKKWFGIVKKRQKSESVKEEGEVILKNEKILSEEKLIDEEGVV
                     VNIDNQILTKVVNDDNEIEEKIIEEDLLISENTIKLDDKEAIINDKNIELCKKEVQVE
                     SEKIGLNKFEGLDQNENYNLEKNVIEEKKVSECLTEEDLEYIKEIKIKRGKSIKAINL
                     YTKEEWVFDTHIQCSKKLKVPLGYIRENLKYGYMDYFGDAINYLSEVLNIDEYCKSEW
                     SYLDNSKSPSEIFNILNNKIFSIRLSNEKRNEILTNDKIEALKMNYRFECIDEEYDEY
                     FKKYKSIIKRGGKKKVELVNKKGDILEIFKSLEECAIYLQKEKNEVIQMLKYGDTKVG
                     RNFIRYSLRSI"
     gene            1474..2616
                     /locus_tag="KRO40_002556"
     CDS             1474..2616
                     /locus_tag="KRO40_002556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH2093373.1"
                     /translation="MSEEKNPKENTLDESKNSDNVNSKKDDVSDEKNTDNKVKKREIK
                     LNNKTLKAIVAIVAVGAICLGGGYVFGKEAGRKLPATSKHYNSSEVVATIGDKKITGE
                     MLRKRMEPLFYLNAKTTMTDDEIRSYESNMIETMITSDILSSEAAKEKISITNDQLDA
                     QYNNLMSSIESAMGMTKEEFLKQFDLTEKYIKDDMKKELVASKYLNEKSKVTDKEAEN
                     YYNKNKSNYLQVRASHILIKTVDDKGKQVSSSKKAELKKEAEEILKKAQAGEDFATLA
                     KKYSEDSSAESGGDLGFFGKGQMVESFEKAAFALKKGEVSNKLVESDYGYHIIKKTDE
                     KYQPFEEVKSDLVSSLTSEKQNLLIQNLKEKYNVKITDKYQMKAKE"
     gene            3070..4461
                     /locus_tag="KRO40_002557"
     CDS             3070..4461
                     /locus_tag="KRO40_002557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH2093374.1"
                     /translation="MSSTESVSKKSGHPKSFWLICMTILWERFSYYGLTALLVLFFTA
                     SVAQGGLGLSTQEATSMFGLFTGLIYLTPLVGGWLADKVLGQQKCISIGALLIAIGDF
                     VLFASSTSIAMVWVGLSIIILGNGFFKSSCSNIVGDIYPKTDVSRKDAAYSLFYMAVN
                     VGAFIAPIICGLLSDNVFAVRGASGDIVSYGYKMAFLICGIGMMLGMIIFTLLAPKLL
                     NEVGKYPVTKGNKGEKIEYGPLTKLEKNRIIAMVILFLFVVLFWTAYYQTQSSFMIYV
                     RDNVNRTLFGFEMPVAWLTSLNAILCVALCPVLATLWVKLSHTKRGDFSIPVKMGLGM
                     IIMGVGFIVMVFATLANGPDGMVKASILFIVLTYIFTTVGELFLSPIGLAMFNKLAPA
                     KYATLSMGAWYLTSFFASLLSGKIAGFTATLGFLQIFGGIATVLIIFGLILLGIRNVL
                     TRLMAMDLLTKEK"
     gene            4714..6507
                     /locus_tag="KRO40_002558"
     CDS             4714..6507
                     /locus_tag="KRO40_002558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBH2093375.1"
                     /translation="MNIKDRLSGLRKFMEEKNIDAYMIPSSDNHQSEYVGDYFKSREF
                     ISGFNGSAGTVIVTKDEAGLWTDGRYFIQAESQLEGSTIKLFKMGQEGCPTTDEYLYK
                     NIPEGGTLGFDGRVISAREGATLAEKLSKKGIKIEYQYDLIDGIWPDRPALSDSKAFL
                     LDVKYCGESFSSKLARLREKMSEKGTSTHVITTLDDIAWLFNIRGGDVKYNPVVLSYA
                     VITLKEVYLFVDESKLNEEILNELAKENVQIKPYNDVYEFVKNIDKTEKVLLDGTKLS
                     YTIYNNIPCEVEKVDEFNPVMFFKAQKNEVELENIRNSHVKDGVAFTKFMYWLKKNVG
                     KMEITEISATQKLEDLRREQEGFFEPSFNTIAAYKEHAAMMHYSATPESNYKLEAEGL
                     FLVDSGGQYYDGTTDITRTTVLGPISDELKLHFTSVARGMINLSKAKFLHGCRGYNLD
                     ILSRSCMWNMGIDYQCGTGHGIGFVLNVHEAPNGFRWRVVPERFDSAVLEEGMVTTNE
                     PGIYIEGSHGIRTENEIVVRKAEKNFYGQFMEFEVVTLAPIDLDGIVPELMNKDEKDY
                     LNWYHKLVYDKISPFLTDEEREWLKVYTRAI"
     gene            complement(6588..7970)
                     /locus_tag="KRO40_002559"
     CDS             complement(6588..7970)
                     /locus_tag="KRO40_002559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH2093376.1"
                     /translation="MSVLKTQEKLKQPRDLYFCCSIFTFVGLAYYGMKLVLLLFLAEQ
                     VSKGGLGLTPAESASMLASFLAWTYFSPVIGGWVSDRFLGPKNCIILGMLMVSIGYFL
                     GYIANSKMDINIMIFLSGLGIGFYKGNLHTMVGNLYTNDDPRKDGAFSITYMATNLGT
                     LFGPLICGLVANEWFAMKSGLSISMYGYRYVFLFSSITVLIGLFFFIFGNRKFYKPLN
                     NDPINGRESIRKSLEYKKMLASRPLTLIEKKRIIVILVLAFFTVFFWIAYNQASMSIA
                     LYTKEHINLTVGNFQIPTSWIDSYNGLLCVILGPISALVWVKLSQTKKGDLSVPKKMS
                     LGFILLAIAFLFMIVAVIQTGTDPNSIHKASVFWVVGFLTFQSIGEICFSPVGYGMVN
                     KLSPEKYISFLMGVWFLGKFAANKLSGYTQAIIDQLGMLQVFIVIPSFLLIFGIILLI
                     MNKKLVELSN"
     gene            8228..8575
                     /locus_tag="KRO40_002560"
     CDS             8228..8575
                     /locus_tag="KRO40_002560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH2093377.1"
                     /translation="MIRKKSELQVEVKENLNGGIGKVKLENIIQNEELKGKGRLFKRV
                     ALPVGSSIGVHDHTTDFEVYYILKGKGKVFDNGEFVEVNEGDVVYTADGEKHSIENIG
                     EEDLEFVALVLYM"
     gene            8593..9627
                     /locus_tag="KRO40_002561"
     CDS             8593..9627
                     /locus_tag="KRO40_002561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093378.1"
                     /translation="MTGKIEEIKDKINRFCNSNLNQEYKDISFKILQNLLDNNKEIIH
                     SSRADIWSSAILNIVLEQNLLYNKKHPLHITKKEFSKQIGVSLNTINNKSSLIKDVCS
                     IDFLNQDTIAISNVEFWVKETNSKSKSVDLDLEKKKILYKRYIKLSQDANSDIESIRY
                     MEEAVNIGKSMITKEDKELGFWKGLSTRAYMIALESLARKLESINNLKESKKVLEYLI
                     EINPSDEQGIRYKLLNVLIRLNDRTSINKLFELYKEEKSATWMYSKALYYFKNKSMFL
                     ANDSIKVARSKNKYVGLYLLDWRNAFGREFVTEEEKAEAVYYYDENIVIWNEVKGSMD
                     WLLKKMLEFS"
     gene            complement(9676..10725)
                     /locus_tag="KRO40_002562"
     CDS             complement(9676..10725)
                     /locus_tag="KRO40_002562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBH2093379.1"
                     /translation="MEINYKKRNFKSFAKRKNIEISVQRYLIDALSYMALGLFSSLLI
                     GTIFNTLGDNFNISLFTEVISPLAKQVTGPAIAVAIAYGLQAPPLVLFSCALVGACGN
                     ELGGPVGAFVATLFAVEVGKLVSKETKIDILVTPAVTILIGVLVAELIGPAVSAFMTS
                     FGNIIMQATTMQPIIMGALVSALVGIALTLPISSAAICMMLSLGGLAGGAATVGCCCQ
                     MVGFAVMSFRENGVGGLVAQGLGTSMLQVPNIIKNWKIWIPPTVASILLGPLSTTIFK
                     MENIPIGSGMGTCGLVGQFGTVTAMQSAGKGGISMWVGILLLNFILPAIVTLLISEFM
                     RKKGLIKPEDLKLDV"
     gene            11000..12535
                     /locus_tag="KRO40_002563"
     CDS             11000..12535
                     /locus_tag="KRO40_002563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093380.1"
                     /translation="MIFVKNKKYRKIAIIISIPILLVAQYYLFKFGILRPMVKGVEIE
                     IVDGEYVKDIDKYVVKLNETVTLSTGEYIKVPSYAKNPNIWFNVLDNSGTLKIDGNKM
                     TALKVGYSSVGIMKNSRVLKKATIKVVDPEVESLDMEINGDLKHVGDSATIESTIEVD
                     YDKFKKSYKPVYKSSNENILKIKGNKVSAVGVGKATIYAKCGNKEIERTFRIQARVAE
                     INMDDIKIEVDQNEKLKPDIITSPPGLEPPKIYYELVDSKLPVERAISLSSNGNVVGL
                     REGKDRVRITCGDKSKVITVTVVKETITNDYIQNLVGSHKIVNNKVIIKLEWDYMKDV
                     FDYDIYLKDKLSGESFKKIKSITINESDLGKSNKVYATIEVDMKGNQNIDFDIYVIGK
                     KDSDTTKPSNVINITNGNGNSNNDNNIKDMRVENISANVDRDNNVIRVNWSSISHKDC
                     TYSIYVKNNTNGDGEFTLYQSDIQGNEHTISIPEGDLNLDIYVVANYNGNSSQNSDVI
                     NVR"
     gene            complement(12720..13406)
                     /locus_tag="KRO40_002564"
     CDS             complement(12720..13406)
                     /locus_tag="KRO40_002564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="HBH2093381.1"
                     /translation="MKTIGLIGGMSWESTITYYQVINTVIKERLGGLHSSKCILYSVD
                     FQEIEECQSSGNWEKSAKILADAAIKLQEAGADFIVICTNTMHKVSDKIQESIHIPLL
                     HIADVTATVLREKEIKKVALLGTKYTMEQDFYKNVIINNGIEVLIPNEEDRIIVNDTI
                     FNELCLGIISESSKKAFLSIIDKLGKQGAEAVILGCTEIGLLIKQNDTSIPLFDTTVI
                     HAIEAALSSI"
     gene            13531..14913
                     /locus_tag="KRO40_002565"
     CDS             13531..14913
                     /locus_tag="KRO40_002565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2093382.1"
                     /translation="MPINSFENYPMTWKPKLDNRKPPIYKTLAMLLEEDIKRGNLNPG
                     DKLPPQRELADFLDLNLSTITRAFKLCEEKGLICAKVGKGTFISSDVNVSNTLLYQTE
                     SKDIIELGTVHPPYEQNTYIIDFIKNVLKQPEMDRFLQYMSPSGTYMQKKSIAKWIER
                     NNVYTSEENILLSTGGQNAICATLLGLFKAGDRIATDSLSFSGIKSIAKMIGIQLVPI
                     PQENNEISIEYLESYCKNENIKGIYLIPDYHNPTTHTMSDLSRKKIAKIAKQYNIIII
                     EDAINSIFRDGIQTPIFSLASDNTIYIFSTSKFLCAGLRVAFVVAPKRYIENLENALY
                     NMNLMVSPFTAEIVHRLLYSPIIDKIIEEKRDAIIERNEVADKVLSDYNLIGDKNCSF
                     RWLLLPDELDGKSFEISAKNLGVQVYCAERFSVGNSTVPKAVRICVTAPKDVEELEKG
                     LNIIKSLLKS"
     gene            15315..16583
                     /gene="eam"
                     /locus_tag="KRO40_002566"
     CDS             15315..16583
                     /gene="eam"
                     /locus_tag="KRO40_002566"
                     /EC_number="5.4.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 2,3-aminomutase"
                     /protein_id="HBH2093383.1"
                     /translation="MNEQTRISLERAAELKSKIDDYIQARKTINRGLEKEEEINKRKQ
                     KILSILNGTEEDWNNYKWQLSNRITDVDTLSKIITLTKKEKEYIKEVGTQFRWAISPY
                     YLSLIDPEDICDPIKLLSIPTHIELEDEQEDLDPMGEEYTNPAGCITRRYPDRLIINV
                     TNECAMYCRHCQRRRNIGQQDSHKSKAIIQESIDYIRENEEIRDVLVTGGDALTLKDD
                     YLEWILSQLKEIPHVDYVRLGTRTLVTMPQRITDEFCNMLKKYHPIYINTHFNHPMEI
                     TKESKEACEKLANAGVPLGNQAVLLNGINNDKFVMRCLNQELLKIRVKPYYIFQSKHV
                     KGTKHFNTSVDDGLEIMEYLRGYTSGMAIPTYIVNAPKGGGKTPLLPQYLVSKGTDYV
                     MLRTWEGKVIKMEDEPAVDIKKLIKEQAQD"
     gene            complement(16676..17032)
                     /locus_tag="KRO40_002567"
     CDS             complement(16676..17032)
                     /locus_tag="KRO40_002567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093384.1"
                     /translation="MKKALISLLVLSCLLLTAPVNESSYADSQKNVPVSQNTKLTQEQ
                     AKELLVKYNNEVDYIYQGNASDFEALKAKNLNGYVFLPDADGDIGYFVNENTSEIYYF
                     HPSGYLELVNQQQNNK"
     gene            complement(17183..18277)
                     /locus_tag="KRO40_002568"
     CDS             complement(17183..18277)
                     /locus_tag="KRO40_002568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH2093385.1"
                     /translation="MQDKKIYLNIVLTVVVSYILIKVIDNYKYFFGVISLLMSLLTPF
                     IIAFVLAYIFNPLVKFLESKLNFKRIYSLLLTYGVLIVILISFILFTVPSIVNSLADL
                     VAQIPTYIDKTEQFLFDLGKSLQSVDPNTLKEYGDKIMSVMPKFSNLLIGSLGGIFST
                     TFSVGKFIVQFLLGFIICFYILLEKEKFLLFTKKVVYISLGKKYGDFIIELCQSLNLN
                     IGKYFTGKILDSFIVGVLSGIGLYFLKSEYALLFGTLMGVMNMVPYFGPVIGMAPVVI
                     INLFSNPTIALTSLIYLIIIQQVEVTFIEPKIVGGQLGLSPFFTILAVTVGGGFFGIP
                     GMILSAPVMGVIKIYFCEFVNRRHDKIQME"
BASE COUNT         7297 a         2147 c         2986 g         5918 t
ORIGIN      
        1 acaaatcaaa tgataatata gtctatttat gtaaatgtta tattgtatcc taagtataat
       61 agtaagtttt ttgatagtgg tgtagaaagt aaaaatctac tagcctaaat tgatgtatgg
      121 attagtttag gaacagtaat tgcatatctt aagtttgatg tcatgttggg ctactagaaa
      181 taggtcatct ttttcacttg aatatctttt ctttaaacat ggggagtatc atatcaaaaa
      241 catatgaaaa ttaagtgatt tatgagaaca gtaatatttt atatgatagt atagaatagt
      301 aataaagtat taggaggaac attgagtgtt aaaaaagtgg tttggtattg tgaaaaaaag
      361 acaaaaaagt gagtcagtaa aagaagaagg tgaagtaata ttaaaaaacg aaaaaatatt
      421 atctgaagaa aagttgatag atgaagaagg agttgtagtt aatattgata atcaaatatt
      481 aactaaagta gtaaatgatg acaatgaaat agaagaaaaa ataatagaag aagatttgtt
      541 aattagtgaa aataccataa aattagatga taaagaagca attattaatg ataaaaacat
      601 agaattatgt aaaaaagaag ttcaagttga aagtgaaaaa ataggtttaa ataagtttga
      661 aggactggac caaaatgaaa attataatct agaaaaaaat gttattgaag aaaaaaaagt
      721 aagtgaatgt ttgacagaag aagatttaga gtacataaaa gaaattaaaa taaaaagagg
      781 aaaaagtata aaagctataa acttgtatac taaagaagag tgggtttttg acactcatat
      841 acagtgtagt aaaaaactca aagttccatt agggtacata agagaaaatt taaaatatgg
      901 atatatggat tactttggag atgcaataaa ttatttaagt gaagtattaa atatagatga
      961 atactgcaaa agtgaatgga gctatctcga taatagcaaa tctccatctg agatatttaa
     1021 tattctaaac aataaaatat ttagtataag gctttctaat gaaaaaagaa atgaaatttt
     1081 gacaaatgat aaaattgaag cattaaaaat gaattataga tttgaatgta ttgatgaaga
     1141 atatgatgaa tattttaaaa aatataagtc tataatcaaa agaggtggaa agaaaaaagt
     1201 tgaattagta aataaaaaag gtgacatttt agaaatattt aagtctttag aagaatgtgc
     1261 catttatttg caaaaggaaa agaatgaagt tatacaaatg ttaaaatatg gagatacaaa
     1321 agtaggaaga aactttataa ggtatagttt gagaagtatt taatttcatt ttaaattcat
     1381 aagagtttca tttctgattc acacatttaa tattatttta atgtaaaata ataaaggtga
     1441 agtattgcac aattaaaatt aaggagggta ttaatgtctg aagaaaaaaa tccaaaagaa
     1501 aatacattag atgaatctaa aaattcagat aatgtaaatt ctaaaaaaga tgatgtgtca
     1561 gatgaaaaaa atactgataa caaagttaaa aaaagggaaa taaagctaaa caacaaaaca
     1621 cttaaagcta ttgtagcaat tgttgcagta ggagctatat gtttaggtgg aggctatgtt
     1681 tttggcaaag aagctggaag aaaattgcct gctacttcaa aacactataa tagcagtgag
     1741 gtagtagcta ctattgggga taaaaaaata acaggtgaaa tgttaagaaa gagaatggag
     1801 ccattatttt atttaaatgc aaaaactact atgactgatg acgaaatacg ttcatatgaa
     1861 tcaaatatga ttgaaactat gattacatct gatatattat cctctgaagc agcaaaagag
     1921 aaaataagta taactaatga ccaactagat gctcagtata ataatttaat gagtagtata
     1981 gaatcagcaa tgggaatgac taaagaagag tttttaaaac agtttgattt gactgaaaaa
     2041 tatataaaag atgatatgaa aaaagagcta gtagcatcaa aatatttaaa tgaaaaatca
     2101 aaagttactg ataaagaagc agagaactat tacaataaaa acaagagcaa ttatttacaa
     2161 gttagagctt cacatatttt aataaaaact gttgatgata aaggtaagca agttagtagt
     2221 agcaaaaaag ctgaacttaa gaaagaagct gaagaaatac ttaaaaaagc ccaagctggg
     2281 gaagattttg ctactctagc taaaaaatac tctgaagata gtagtgcaga atcaggtgga
     2341 gatttaggtt tctttggtaa aggtcagatg gtggaatctt ttgaaaaagc agcctttgca
     2401 ttgaagaagg gagaggtatc taacaaactt gtagaaagtg attatggata tcatataatt
     2461 aagaaaactg atgaaaaata tcagccattt gaagaggtaa aatcagattt agtaagcagt
     2521 ttaacatcag aaaaacaaaa cctacttata caaaatctaa aagaaaaata taatgttaaa
     2581 attacagata aatatcaaat gaaagctaaa gaatagataa agtcaattta ttaaaaaaaa
     2641 gaaaaattaa ctgtatggat aaaagctatt tttactctca atatagagag tataaaatag
     2701 cttttattat tttgtaataa aatctattta tatatatgaa gtgataaaga aataacatgc
     2761 aaaaaggtat taaaaagaaa tatttttaat ttgaattttt tcaataaaaa tttacaaaaa
     2821 tgaaaaaata aacaaaaaag aattgaagat ttaagttgtt atttaaatat atatatatta
     2881 agattttctg ctgaagatac taaaaaaata atatttttca taattttaaa aataataata
     2941 aaaaaatgaa aatacaggct ataatctatt gagtaaacat agaaaagatg atattataag
     3001 tatgtgctaa aatggttaaa gcaatattaa tattaaattt aactataaaa caaaaggggg
     3061 cgttttttta tgtcaagtac agaaagcgta tctaaaaaaa gtggtcatcc gaagagtttt
     3121 tggcttattt gcatgacaat tttgtgggaa agatttagtt attatggttt aacagcttta
     3181 ttggtattat tttttacagc aagtgtagct caaggtggtt taggtctttc tactcaagaa
     3241 gcaacatcta tgtttggctt atttacaggt cttatatatc ttacaccatt agtcggtggc
     3301 tggttagcag ataaagtttt aggtcaacaa aaatgtattt ctataggtgc acttttaata
     3361 gcaataggag atttcgtact atttgcttca tctacatcta ttgcaatggt ttgggtaggt
     3421 ctatcaataa ttattttagg aaatggtttt tttaaatcaa gttgctcaaa tatagttggg
     3481 gatatatatc ctaaaactga tgtgtcaaga aaagatgcag catacagttt attctatatg
     3541 gcagtaaatg taggagcatt tatagctcca ataatatgtg gattgctttc tgataatgta
     3601 tttgcagtaa gaggagcaag tggagatata gtatcttatg gatataagat ggcattttta
     3661 atttgtggta taggcatgat gttaggtatg attatattta cacttcttgc accaaaatta
     3721 ttaaatgaag tcggaaaata tcctgtgact aaaggtaata aaggtgaaaa aattgagtat
     3781 ggaccactta ctaagttgga gaaaaatagg ataatagcaa tggttatttt atttttattt
     3841 gtggtcttat tctggacagc atactatcaa acacaaagtt cttttatgat ttatgtaagg
     3901 gataatgtaa atagaactct atttggattt gaaatgccag tagcatggct tacatcacta
     3961 aatgctatat tatgtgtggc tttatgccca gtattagcta ccctatgggt taaattatct
     4021 cataccaaaa gaggtgattt ctctattcca gttaaaatgg gattaggaat gataataatg
     4081 ggtgttgggt ttatagttat ggtatttgct acattagcta atggtccaga tggaatggta
     4141 aaggctagta tattgtttat agtattgact tatatattta caacagtagg tgaattattc
     4201 ttatctccta taggacttgc aatgttcaat aaattagctc cagctaagta tgctacgttg
     4261 tctatgggag cctggtatct aacaagtttt tttgcaagtt tattatcagg aaagattgct
     4321 ggttttacag ccacacttgg ttttttacag atatttggag gaatagcaac agttttaata
     4381 atatttggtt taatattatt gggaataaga aatgtattaa caagattaat ggctatggat
     4441 ttactaacaa aagaaaaata attcatgacg aattattgta aataaatgaa ttactttaaa
     4501 taaaggaagt tacatttaaa tataaaatta aatgtaattt cctctttgat tatgaaaaaa
     4561 agctttacac aaatagatat tataattaaa attataattg tgataattag agtgtataag
     4621 atttatataa attatacaaa aaatatttat gtaataaact ttacatactt atatatttag
     4681 ttattcaaac tattatttcg aggaggtctt gttgtgaata taaaagatag attaagtgga
     4741 ttaagaaaat ttatggaaga aaaaaatata gatgcctata tgattccatc ttctgataat
     4801 caccaaagtg aatatgtagg agattacttc aaatcaagag aatttatatc agggtttaat
     4861 ggttcagcag ggacggttat tgtgactaaa gacgaagctg ggttatggac agatggaaga
     4921 tattttatac aggcagaatc tcaattagaa ggaagtacaa taaaattatt caaaatggga
     4981 caagaaggtt gcccaactac agatgaatat ttatataaaa atattcctga aggaggaact
     5041 ttaggatttg atggtagagt tatatctgct agagaaggag ctacattagc tgaaaaatta
     5101 tctaaaaaag gtataaagat agaatatcag tatgatttaa tagatggtat atggccagat
     5161 agacctgctt tatcagatag taaagcattt ttattagatg ttaaatattg tggagaaagt
     5221 tttagctcaa aattagctag attaagagaa aaaatgagtg aaaaaggtac ttctactcat
     5281 gtaataacta ctcttgatga tatagcatgg ttattcaata taagaggtgg agatgttaaa
     5341 tataatccag ttgtactttc ttatgcagta ataactttaa aagaagttta tctatttgtt
     5401 gatgaaagta agttaaatga agaaatacta aatgaactag ctaaggaaaa tgttcaaata
     5461 aagccatata atgatgtgta tgaatttgta aaaaatatag acaaaactga aaaagtttta
     5521 ttagatggaa ctaagcttag ttatacaatt tacaataata taccttgtga agttgagaaa
     5581 gttgatgagt tcaatccagt aatgtttttt aaagctcaaa aaaatgaggt agaattagaa
     5641 aatataagaa attcacatgt aaaagatggt gtagctttca ctaaatttat gtactggtta
     5701 aagaaaaatg taggtaagat ggaaatcact gaaataagtg ctactcaaaa attagaggac
     5761 ttaagaagag agcaagaagg tttctttgag ccaagtttca atacaattgc tgcatataaa
     5821 gagcatgctg caatgatgca ctatagtgca actccagagt caaattataa attagaggca
     5881 gaaggattat ttttagtaga ttcaggtgga caatattatg atggaactac tgatataact
     5941 aggactacag ttttaggacc tataagtgat gaattaaaac tacactttac ttctgtagca
     6001 agaggaatga taaatctttc taaggctaag ttcttgcatg gttgtagagg atataactta
     6061 gacatactat ctagaagttg catgtggaat atgggaattg attatcaatg tggaactgga
     6121 catggtatag gatttgtgct aaatgttcac gaagctccaa atggatttag atggagagta
     6181 gtacctgaaa gatttgatag tgcagttctt gaagaaggaa tggtaactac taatgaacca
     6241 ggtatatata tagaaggttc tcatggtata agaacagaga atgaaattgt agttagaaaa
     6301 gctgaaaaga atttctatgg tcaatttatg gaatttgaag ttgttacgtt agctcctatt
     6361 gacttagatg gtatagtacc agaattaatg aataaggatg aaaaagatta tttaaactgg
     6421 tatcataagt tagtttatga taaaatatca cctttcttaa ctgatgaaga aagagaatgg
     6481 ttaaaagttt acactagagc tatatagttt gtactagata caataaaaat cgaggtatta
     6541 taatgcctcg attttttatt gtatatttta ttaactttaa aaaattttta atttgataat
     6601 tctactaatt ttttattcat tataagtagt ataattccaa atatcaataa aaatgatggt
     6661 atcactatga agacttgtaa cataccaagt tggtctataa tagcttgcgt atagccagat
     6721 aatttatttg ctgcaaattt gcctaaaaac caaacaccca ttaggaatga aatatacttt
     6781 tcaggcgaaa gtttatttac cataccatac ccgactggag aaaagcaaat ttctcctata
     6841 ctttggaatg ttaaaaatcc aactacccaa aatacacttg ctttgtgaat tgaattaggg
     6901 tctgttcctg tttgtataac tgctactatc ataaacaaaa atgctatggc taatagtata
     6961 aaacctaagc tcattttttt tggcacactt aaatcgcctt ttttagtttg agataatttt
     7021 acccatacta aagcagagat aggtccaaga ataacacaaa ggagaccatt gtatgaatct
     7081 atccatgaag taggaatttg aaaattgcca acagtaagat ttatgtgttc ctttgtatag
     7141 agtgcaatag acatagaggc ttggttatat gctatccaaa aaaatactgt gaaaaaagct
     7201 aacaccaata ttactattat tctttttttc tcaatcaaag ttaaaggtct tgaagcgagc
     7261 attttcttat attctagtga ttttcttata gactctctcc cgttaatagg gtcattattc
     7321 aaaggtttat aaaactttct gtttccaaat ataaagaaga ataaacctat tagaaccgta
     7381 attgatgaaa ataaaaatac atatctatat ccatacatac ttatagataa tccgcttttc
     7441 atagcaaacc attcattagc aactaaaccg catattaaag ggccaaataa agtacctaga
     7501 ttagtagcca tatacgtaat agagaaagct ccatcttttc ttgggtcatc attggtatat
     7561 aagtttccaa ccatagtatg taagtttcct ttataaaaac ctattcctaa tccagataaa
     7621 aatatcatga tgtttatatc catcttacta tttgctatgt atcctagaaa ataaccaatt
     7681 gaaaccatta gcattccaag tataatacag tttttgggac ctaaaaatct atcactgacc
     7741 catccaccaa taactggaga gaaataagtc catgctaaaa aagatgcaag cattgatgcg
     7801 gattctgctg gtgttaaccc taaaccacct ttggagactt gttcagctaa aaacaataat
     7861 aataccaatt tcataccata gtatgcaagt cctacaaagg taaatattga acagcagaaa
     7921 tataaatctc taggttgttt aagtttttct tgcgttttta aaactgacat atgtcgagaa
     7981 cctccagata aatagtttaa caaaatttta ccatactata tgagtatatg tttttttcat
     8041 atagacgtca acttgtaaga taatttaatt aagtcgaaat atatgtaaaa atagtatcat
     8101 ttttgtgtat tcagtaatat ttttttatga taatatatgt tattattata ttaaaataca
     8161 aacatattta tggaaaggat atgccaattt agtagttaga ttgattgttt ggcaggtggg
     8221 atgagctatg ataagaaaga aatctgaatt acaagtagaa gtaaaagaaa atttaaatgg
     8281 tggtatagga aaggttaagc ttgaaaacat aatacaaaat gaagagctta aaggaaaagg
     8341 aagactattt aaaagagtag ctttaccagt aggaagttca attggtgtgc atgaccatac
     8401 aacagatttt gaagtatatt atatactaaa gggaaaaggt aaagtatttg ataatgggga
     8461 atttgtagaa gtaaatgagg gtgatgtagt gtatacagct gatggcgaaa aacattctat
     8521 agaaaatata ggagaagaag atcttgagtt tgtagcacta gttttatata tgtaaaatat
     8581 ggaggaggag tcatgacagg caagatagaa gaaattaagg acaagataaa tagattttgc
     8641 aactccaatt taaatcaaga atacaaagat ataagcttta aaattttgca aaacctttta
     8701 gataataata aagagataat tcattcttct agagctgata tatggtcttc agctatacta
     8761 aatatagttt tagaacaaaa tcttttatac aataagaagc atccactaca tataacaaaa
     8821 aaagagtttt caaaacaaat aggtgtttct ttaaatacta taaataataa atcgtcttta
     8881 ataaaagatg tttgtagtat tgacttttta aatcaagata ctatagctat ttctaatgta
     8941 gaattttggg taaaagagac taattccaaa tcaaagtctg tagatttaga tttagaaaag
     9001 aagaaaatac tatataaaag atatattaag ctatcacaag atgcgaatag tgatattgaa
     9061 tcaattagat atatggagga agctgtaaat ataggtaaaa gtatgattac taaagaagat
     9121 aaagaacttg gattttggaa aggtttatct accagagcct atatgatagc acttgaatcc
     9181 cttgctagaa agttagaaag tattaataat ctaaaggagt ccaaaaaagt attagaatat
     9241 ttaatagaaa ttaatcctag tgatgagcag ggaataagat acaaattatt aaatgtatta
     9301 attagattaa atgatagaac ttcaataaat aaattatttg aactttataa agaagaaaaa
     9361 tctgctacat ggatgtacag taaagctctt tattacttta aaaataaaag tatgtttttg
     9421 gcaaatgatt ctattaaggt tgctagaagt aaaaataagt acgttggatt atatttgtta
     9481 gattggcgaa atgcttttgg tagagaattt gttacagagg aagaaaaggc agaagctgtc
     9541 tattactatg atgaaaacat agtgatttgg aatgaagtta aaggttctat ggattggcta
     9601 ttaaaaaaaa tgttggaatt ttcataaaaa aaactactcc ttacttttat ataagtaaaa
     9661 ggagtagttt ttaatttata catctagttt taaatcttca ggttttatta gacctttttt
     9721 tctcataaat tctgaaatca acaaagttac aatagcagga agtataaaat taagtaaaag
     9781 tataccaacc cacatagata tacctccttt tccagcactt tgcatagcag ttactgttcc
     9841 aaattgtcca accaatccac aagtacccat accagaacca ataggaatat tctccatttt
     9901 gaatattgtt gtagataatg gtccaagtaa tattgaagct acagtaggtg gtatccaaat
     9961 tttccaattt tttattatat taggtacttg caacatagat gtcccaagac cttgtgccac
    10021 aaggccacca actccatttt ctctaaagct cataacagca aagcctacca tttggcaaca
    10081 acaacctaca gttgctgcac caccagcaag accacctaaa cttaacatca tacaaatagc
    10141 tgcactactt ataggtaatg taagagctat tccaacaagt gcagagacta aagctcccat
    10201 tattataggt tgcatagttg tagcttgcat tattatattt ccaaatgaag tcataaaagc
    10261 agaaacagct ggaccaataa gttcagctac aagtactcca attagtattg tcacagcagg
    10321 tgtaaccaat atatctattt ttgtttcttt tgaaactaat tttccaacct ctacagcaaa
    10381 aagtgtagcg acaaatgctc caacaggtcc tcctaattca ttaccacaag ctccaacaag
    10441 tgcacaagaa aatagtacaa gtggaggtgc ttgaagtcca tacgcaatag ccactgctat
    10501 agctggacca gtaacctgtt tagcaagagg gcttataact tcagtaaaaa gagaaatatt
    10561 gaaattatct cctaatgtat tgaaaattgt tccaattaaa agggacgaaa aaagaccgag
    10621 tgccatataa cttagtgcgt caataagata cctttgaaca gaaatttcaa tattttttct
    10681 tttagcaaat gatttgaaat ttcttttttt ataattgatt tccaatttaa aatcctcctc
    10741 atataatata agtataattt ctttttaatt aattatataa cttttcagct gacaagacaa
    10801 atgttatttc actaaaatta gactattgta atagtaagaa attaacatta attttagttt
    10861 taaattttaa atttatggtt tataattagt atagggatat tctgaaatat aataattttc
    10921 cagtttatcc caatatttaa cttaggtaga ttgcttacaa aacaaatgat tatatattag
    10981 gctaaaagga agtggataga tgatatttgt aaaaaataag aaatacagaa aaattgccat
    11041 aattatatct attcctatat tgcttgttgc gcagtactac ctttttaaat ttggaatact
    11101 tagaccaatg gtaaagggag tagaaattga aattgtagat ggggaatatg ttaaagatat
    11161 agataaatat gtagtaaaat taaatgaaac agttactttg tctacaggtg aatatattaa
    11221 ggttccttcg tatgctaaaa atccaaatat ttggtttaat gtattggata actcagggac
    11281 tttaaaaata gatggaaata aaatgacagc attaaaggtt gggtattctt ctgtgggtat
    11341 catgaaaaat tcaagagtat taaaaaaggc tactataaaa gtagtagacc cagaggtaga
    11401 atcactagat atggagatta atggggattt aaaacatgtt ggtgatagtg ctactataga
    11461 aagtacaata gaagttgatt atgataagtt taaaaaatca tataagccag tttataagag
    11521 tagcaatgaa aatattttaa aaatcaaagg aaataaagta agtgcagttg gagttggtaa
    11581 agctacaata tatgctaagt gtggaaataa agaaattgag agaacattta ggattcaagc
    11641 tagagttgct gaaataaata tggatgatat aaaaatagaa gttgaccaga atgaaaaatt
    11701 gaaaccagat ataataactt ctccacctgg tttagaacca ccaaaaatat attatgagtt
    11761 agtagattca aaattacctg tagaaagagc aataagttta agtagtaatg gaaatgttgt
    11821 agggcttaga gaaggtaaag atagggtgag aataacttgt ggagataaat ctaaagtaat
    11881 aacagtaaca gtagtcaaag aaactataac gaatgactat atacaaaact tggttggttc
    11941 gcataaaata gtaaacaata aagttattat taaacttgaa tgggattata tgaaagatgt
    12001 ctttgattat gatatatatc ttaaagataa gttgtcagga gaatcattta agaaaattaa
    12061 atctataact ataaatgaaa gtgatttagg taagtctaac aaggtatatg cgactataga
    12121 agtagatatg aagggtaatc aaaatataga ttttgatatt tatgtcatag gtaaaaagga
    12181 ttcagataca actaagccaa gtaatgtaat aaatattacc aatggaaatg gaaattcaaa
    12241 taatgataat aatattaaag atatgagggt agaaaatata tcagctaatg ttgatagaga
    12301 taataatgtc attagagtta actggagtag tatatctcat aaggactgta cttacagtat
    12361 atatgtaaaa aataatacta atggagatgg agaatttact ctatatcaaa gtgatataca
    12421 gggaaatgag catactataa gtattcctga aggagattta aatctagata tttatgttgt
    12481 tgcaaattat aatggaaata gctctcaaaa tagtgatgtt ataaatgtaa gatagatttg
    12541 tatacaaatt gaaagtgttg agtttattta aatattaaat taagaaaaag gatagtatag
    12601 ggtaattata ctatcctttt ttgttacaat atataggttt aaaatctcta gtaatataaa
    12661 ttataaaaag tcttatttac acaaatctat agatattttt tttattaatc aatattgtct
    12721 taaattgaac ttagtgcagc ttctattgca tgtattactg tcgtatcaaa tagtggaata
    12781 gaagtgtcat tttgtttaat taaaagacct atttctgtac atcctaatat aacagcctct
    12841 gcaccttgtt tgccaagctt atctataata gataagaaag ctttttttga agattcagat
    12901 ataattccta agcaaagttc attaaatatt gtgtcattta ctattatacg gtcttcttca
    12961 tttggaatta agacttcaat tccattatta ataattacat ttttataaaa atcttgttcc
    13021 attgtatatt tagtacctaa taaggccact ttttttattt ctttttccct taataccgta
    13081 gcagttacat ctgctatgtg aagtaatgga atatgtatac tttcttgtat tttatctgat
    13141 accttatgca tagtattagt acagataaca ataaaatctg cccctgcctc ttgtaattta
    13201 attgcagcat cagctaaaat tttggcgctt ttttcccaat ttccactaga ttggcattct
    13261 tcaatttctt gaaaatctac actgtaaagt atacatttag aagagtgtag tccacctaat
    13321 ctttctttta ttactgtatt aataacttga taatatgtaa tggtactttc ccaactcata
    13381 ccaccaatta agcctatagt cttcatatta tacctctctt atttatttat tttgaaatag
    13441 ctatttacaa atacaagtat agcatctaaa atagaagcat acaataataa aattgtatgg
    13501 agtacaatta taattaagag gagtaattat atgccaataa attcttttga aaactatcct
    13561 atgacatgga aaccaaagtt agataaccga aaaccaccaa tatataaaac tttagcaatg
    13621 ttattagaag aagatattaa aagaggaaat ttaaatcctg gagataaact gcctccacaa
    13681 cgggaattag cagattttct agatttaaac ttaagtacaa taacacgagc atttaaactt
    13741 tgcgaagaaa agggactaat atgtgcaaaa gtgggaaagg gaacattcat ttcttctgat
    13801 gtaaatgtaa gtaatacatt attatatcaa acggaatcaa aagacataat tgagttgggg
    13861 acagttcatc ctccgtatga gcaaaataca tatattattg actttattaa aaatgtacta
    13921 aaacaaccag aaatggatag gtttttacaa tacatgtctc catctggcac atatatgcaa
    13981 aaaaagtcaa ttgcaaaatg gatagaaaga aataatgtat acaccagtga agaaaatata
    14041 ttattatcta caggagggca aaatgctata tgtgcaactt tactaggatt atttaaagct
    14101 ggtgatagaa ttgctacaga ttctttaagt ttttctggaa ttaagtcaat agctaaaatg
    14161 ataggtattc aattagtccc aattcctcaa gaaaataatg aaatatcgat tgaatatctt
    14221 gaaagttatt gtaaaaatga aaatataaaa ggcatatatc ttataccaga ttatcataat
    14281 ccaacgacac atactatgtc tgatttatct cgtaaaaaga tagccaagat agcaaagcaa
    14341 tacaatataa taattattga agatgctata aatagcattt ttagagacgg tatacaaact
    14401 cccatatttt ctttagctag tgataatact atatatattt ttagtacatc taaattttta
    14461 tgtgctggtc ttagagtagc atttgtagtt gctccaaaac gatatataga aaatttagaa
    14521 aatgcactat ataatatgaa tctaatggtt tctccattta cagcagaaat agtacaccgt
    14581 ttattatatt ctcctattat agataaaatt atagaagaga aaagagatgc aattatagaa
    14641 agaaatgaag ttgctgataa agttttgtca gattataatt tgattggtga taagaattgc
    14701 agttttcgtt ggttacttct tcctgatgaa ttggatggaa aatcatttga aatttctgca
    14761 aaaaatctag gagttcaagt atattgtgct gaacgatttt cagtaggaaa ctctacagtt
    14821 ccaaaagcag ttcgtatttg tgtaacagct ccaaaagatg tagaagaatt agaaaaaggg
    14881 cttaatataa taaagtcact tcttaagagt taaatttatt ttactattat ttaattaaat
    14941 aaataaaaag gcggagaaat ttattataat aaacctccgc ttttattatt taatgaaata
    15001 ctttactttt tattaaaaaa tttaatttta ataatcttga aaatataatc gttttatggt
    15061 aaaataattc ttaaaaatag aaaaaattaa tcatttgtta aaaaaaatgc ataatttatt
    15121 gtaatttatt gacgaaggtt gaaaaatatt cataaatgtg cgaaataaca gaaaaaatgc
    15181 aaaaattaat tcaatttcat ttgttataaa atctatatgg caaaattaaa tctgcctatc
    15241 agaatgatat aaacacatca gaaaggagga cgctatcaaa taatacaagt agttaacttt
    15301 gatagcaaaa aattatgaat gaacaaacta gaatatcctt agagagagct gctgaattaa
    15361 aatcaaaaat tgatgattat attcaggcta gaaaaacgat taacagaggt cttgaaaaag
    15421 aagaagagat aaataaacga aaacagaaaa tattaagtat cttaaatgga actgaagagg
    15481 attggaataa ctacaaatgg caattatcaa atagaataac agatgtagat actttatcaa
    15541 aaattataac tctaactaaa aaagaaaaag aatatataaa agaggttggt actcaattta
    15601 gatgggcaat atctccatat tatttgagtc ttatagaccc agaagatata tgtgacccaa
    15661 taaaattact gtctatacca acacatatag agttggaaga tgagcaagaa gatttggacc
    15721 caatgggaga agagtataca aacccagcag gatgtataac tagaagatac ccggatagat
    15781 taataataaa tgtaacaaat gagtgtgcta tgtattgtag acactgtcag agaagaagaa
    15841 atattggaca acaagattct cataagtcaa aagctattat ccaagaatct atagactata
    15901 tcagagaaaa tgaagaaata agagatgtac tagtaactgg tggagatgct cttacattaa
    15961 aagatgatta tttagagtgg attcttagcc aacttaaaga gataccacat gttgattatg
    16021 ttagattagg tactaggact cttgttacaa tgccacaaag aattacagat gaattttgca
    16081 atatgctaaa aaaatatcac cctatatata taaatactca ttttaatcat ccaatggaaa
    16141 taactaagga atctaaagaa gcttgtgaaa agttagcaaa tgcaggcgtt ccattaggaa
    16201 atcaggcagt attattaaat ggaataaata atgataaatt tgtaatgaga tgtttaaatc
    16261 aagaattact gaaaataaga gtaaaacctt attatatatt ccaaagtaaa catgtaaagg
    16321 gaacaaaaca tttcaataca tcagtagatg atggtcttga aatcatggag tatttaagag
    16381 gatatacatc aggaatggct ataccaacat atatagtaaa tgctccaaaa ggaggaggaa
    16441 agactccttt gcttcctcaa taccttgtat caaaaggaac agattacgtt atgcttagaa
    16501 catgggaagg aaaagttata aaaatggaag atgaacctgc tgtagatata aagaaactta
    16561 taaaagaaca agcacaggat taaaaaaata tttaaagttt ataaaaagaa acaactttaa
    16621 aataaaaaga aaatggatgt caaatttata tcaatttgca tccatttttt attagttatt
    16681 tattattttg ttgttgatta actaattcaa gatatccact tgggtggaag taatatatct
    16741 cagaagtatt ttcatttaca aagtaaccaa tatcaccatc tgcatctggt aaaaatacat
    16801 aaccattaag atttttagct tttaatgctt caaaatcact agcatttcct tgatatatgt
    16861 aatcaacttc attgttgtat tttactaaaa gttctttagc ttgttcttga gtcaatttag
    16921 tattttggct tacaggaaca ttcttttgag aatctgcata agaagattca tttactggtg
    16981 cagttaataa caaacaagat aaaactaata aagatataag tgcttttttc atactaaaac
    17041 cctctttcat gtttaattat ataagattca ttacttaata atattgtatg tttcctataa
    17101 ttaaatatta ccattaaaga gaataatatt acagttacac agctgtaact tttgattaca
    17161 aaatcgtaat taaattgtat ttttattcca tttgtatttt atcatgtcta cgatttacaa
    17221 actcacagaa gtatatcttt ataacgccca tcacaggagc agatagaatc ataccaggta
    17281 taccaaagaa tcctccacca acagtaactg ctaggattgt aaagaatggg ctaagaccta
    17341 gttgtccacc tacgattttt ggctctataa atgtaacttc aacttgttga attattatta
    17401 agtaaattaa agaagttaaa gcaattgttg gattggagaa taaattaatt attacaactg
    17461 gtgccatacc tattactgga ccaaaatatg gaaccatatt catgacaccc ataagtgtac
    17521 caaataatag tgcatattca gattttaaaa agtaaagacc aattccagaa agtactccaa
    17581 ctataaaaga atctaaaatc ttacctgtaa agtatttacc aatatttaaa tttaagcttt
    17641 gacatagttc tattataaag tctccatatt ttttacctaa ggaaatataa actacttttt
    17701 ttgtaaacag taagaatttt tctttttcta ataatatata gaaacaaatt ataaaaccta
    17761 aaagaaattg tactataaat tttccaactg aaaatgtagt gctaaatatc ccaccaagtg
    17821 aaccaataag caagttacta aatttaggca ttacactcat aattttgtca ccatactctt
    17881 ttaatgtatt agggtcaact gattgtaaac tcttgcctaa gtcgaataaa aactgctctg
    17941 ttttatctat gtatgtagga atttgagcaa ctaaatcagc taaactattt actatggatg
    18001 gaactgtaaa taatataaac gaaattagta taactatgag tacaccataa gtaagaagta
    18061 acgaatatat tctcttaaaa tttaatttac tttctaagaa ctttactagt gggttgaata
    18121 tatatgctaa tacaaatgct attataaatg gtgttagtag tgacattaat aaacttatca
    18181 ctccaaaaaa atatttgtaa ttatcaataa ctttaatcaa gatatatgaa acaactacag
    18241 tgagtacaat atttagataa atttttttat cttgcaaaat aacacaacct ttcttatatt
    18301 tattaaattt agatatactt aaatctaagt taaagttaat atttatag
//
LOCUS       DAEQCW010000077        17451 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.077, whole genome shotgun sequence.
ACCESSION   DAEQCW010000077 DAEQCW010000000
VERSION     DAEQCW010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17451)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17451)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17451
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.077"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            218..1102
                     /locus_tag="KRO40_002569"
     CDS             218..1102
                     /locus_tag="KRO40_002569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBH2093386.1"
                     /translation="MDTTKIDDISKLDLNNLDINKMDMGGIMESLLEWATTSGVKLII
                     GILILSIGFKIIKKFVNHVMLVLSKRDIDLTLRRFLKSLLLSVLKVAVIIIVLEYWGM
                     SLSSFAAVIASAGVAIGLALQGSLSNFAGGFIILLIRPFKVGDYVEAAGHGGTVEQIG
                     LFYTQLVTPDNKQILIPNGSVSNDSLINYSAKNTRRVDLTFSVGYEDDILHVRRVLKD
                     IVNNHKLIINEPEPFIGVVEHGDNAIKFATRVWCKTEDYWTIYLDLLEEVKVRFDEEG
                     ITIPYPKMDLTVKELNKI"
     gene            1463..2080
                     /locus_tag="KRO40_002570"
     CDS             1463..2080
                     /locus_tag="KRO40_002570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HBH2093387.1"
                     /translation="MCKKTYLLVVSILIAGLLTACSGSPTTDSGQAQDNTKKEANASN
                     NALKDEKNNENLMEQDFKVPYTDAINIFKDKYKDADIVDLSLERDLNKFVYTVEGVDD
                     NNEYKMKIDANTKDVLEDKTEKLDSEDLNGVARKEKLDLNDIMTPQQAMEIALKEQNG
                     IVKEWSLDKDLDVTFYKIRIDKDKNEYDIKVDSKKGTVLKVEKED"
     gene            2188..4719
                     /locus_tag="KRO40_002571"
     CDS             2188..4719
                     /locus_tag="KRO40_002571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH2093388.1"
                     /translation="MSLKSLKIKENLYWVGSLDPDLRVFDIIMYTPYGTTYNSYVLKG
                     TEKTVLFETVKDKHFDNYIERLNDLNIDFEKIDYIVVSHTEPDHAGSVEKLLDLAKNA
                     KVVASETAIKYLKEIVNKDFEYVAVTDGDTLSIGDKTLEFFSVPMLHWPDTIYTYIKE
                     DKTLVTCDSFGSHYSNDKIVNTLDENEEKDYLDALRYYYDCIMGPFKPSMVTAIEKIK
                     DLDIDTVCPGHGPVLTENPRKIIDLYYNWSVNEQIKLEKEVTICYVSAHGYTKIMAEA
                     IKAYIEKNSNYKVNLFDVIEHKQEDILAKIAVSQGVLFGTPTILGDALKPIWDILISL
                     NPVLHGGKVASVFGSYGWSGEGIENAMERISQLRMTAVKPFAVNFKPSNEEIDKLHSY
                     TGKFLDKLNSTFGSKKKTKKFKCVICNEVFEGDSAPSVCPVCGAKEDQFIEVEEDEVT
                     FRKDTDEYFVIVGNGAAGFYAADAIRKRNKTCKITMISNEDELTYYRPALSDGINEEL
                     GSDFYMEDKDWYDKNNIVVILGTNVDKLDEVNKTIIVNDGAIKFDKLVIATGSRNFIP
                     PIKGHDLENVFTLRNIKDLYSVKEALEKSKKVVVIGGGLLGLEAAWEFRLKGLEVVVV
                     EAMDSILSKQLDKEGSKILEQCVRDTGIDVRLGVAVDGIEGDGKAQKVVFKDGDSVDC
                     DMVVFSIGVRANTQMVQDTSVKIDRGIVVDKTLQTNVKDIYACGDVAQVGNISLAIWP
                     SSVEMGKIAGANASGDNLTFESEVYPVSLDAMNVKVFSIGNIQNFDKEISSKDEGQRI
                     YKKLFMKDGSLVGAILINDLSCTVKLIRLISEKGDFEDIMKADIL"
     gene            5153..5854
                     /locus_tag="KRO40_002572"
     CDS             5153..5854
                     /locus_tag="KRO40_002572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBH2093389.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
     gene            5904..6986
                     /locus_tag="KRO40_002573"
     CDS             5904..6986
                     /locus_tag="KRO40_002573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2093390.1"
                     /translation="MRTALMAFIAIIFIWILYSFILYGKFSIWIVSFFENAFRMEYKA
                     ALNLYQQIFRNSMELFMILAMVIVFFIIFRVYLNWFTKYFSEINQGIDSLIKEDVGEV
                     ALSPELLAIEKKINSIKHILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTL
                     LRDESQISEELRKKYLSISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLE
                     QLTYEFKPTLMSKNLKYTLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEIT
                     AVQEDDYIKLKFMNHSNTIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVEL
                     HNGTITAHSENNIITFKVIIPIVGNL"
     gene            7247..8347
                     /gene="vanG"
                     /locus_tag="KRO40_002574"
     CDS             7247..8347
                     /gene="vanG"
                     /locus_tag="KRO40_002574"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBH2093391.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNDDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            8344..9150
                     /locus_tag="KRO40_002575"
     CDS             8344..9150
                     /locus_tag="KRO40_002575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH2093392.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            9168..11306
                     /gene="vanT"
                     /locus_tag="KRO40_002576"
     CDS             9168..11306
                     /gene="vanT"
                     /locus_tag="KRO40_002576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBH2093393.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKHLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVNMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINDCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLAE
                     LSASEVANNSCSISNELLSRVGRRLNVIKK"
     gene            11620..12240
                     /locus_tag="KRO40_002577"
     CDS             11620..12240
                     /locus_tag="KRO40_002577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBH2093394.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
     gene            complement(12406..12942)
                     /locus_tag="KRO40_002578"
     CDS             complement(12406..12942)
                     /locus_tag="KRO40_002578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBH2093395.1"
                     /translation="MIKETHERGGYIFALLILPFINNLYLVKYDIAYKIVLIIIYIYF
                     AYLGSLFPDIDMRGSYISKKFMLIYKLFGSRFRHRGFTHSLIALLLIYSFFKSLTIFT
                     NNNIVFSCLSSGFIIGYLSHLCLDLITKEGIELFYPITINISLLPIKTNSKTEKFISK
                     LLNFIVIFLIGYQFYILL"
     gene            complement(13055..13729)
                     /locus_tag="KRO40_002579"
     CDS             complement(13055..13729)
                     /locus_tag="KRO40_002579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HBH2093396.1"
                     /translation="MSLFIISQCITSFAFTPENNKFKVKPLPYAYDALEPYIDKETMK
                     LHHDKHYQAYVDKLNAALEKYPELYNYSLCELLQNLDSLPKDIATTVRNNAGGAYNHK
                     FFFDIMTPEKTIPSESLKEAIDRDFGSFEKFKQEFQKSALDVFGSGWAWLIATKDGKL
                     SIMTTPNQDSPVSKNLTPIIGLDVWEHAYYLKYQNRRNEYIDNWFNVVNWNGALENYK
                     NLKSQD"
     gene            13932..15806
                     /gene="asnB"
                     /locus_tag="KRO40_002580"
     CDS             13932..15806
                     /gene="asnB"
                     /locus_tag="KRO40_002580"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBH2093397.1"
                     /translation="MDGNISIYYKGDISKKEDIKFKIKESVNNTRLSSRIEYKDEEKT
                     FDFERFNVIDAIYGNKPFEKDGKVIVFNGNIYNYHEIKEELIKKGHNFTTNDDIEVLL
                     ASYIEFGKNCVHKIKGMFNFIIYDRENESIFGARDLFGIKPLYYINKENAIIFSSEYK
                     FLLEYMKNLNINERSLQSYFSFQYVLPEDTMIQGIRLIPAGHYFRVENGILSLKRYNK
                     LEFRSSTKFFYTKNHLGNRDVNEDDIRNIVVDSIVTHMEEEKEIGTFLSGGIDSSIIT
                     TVASQINPNIKSFSAGFSVKGYSELEVAKKTADKLGIENIQINITQDEYIKSLPNVIY
                     SLDDPIADPSEVGLYFLIKEAGKHVKVALSGEGADELFGGYNIYKEYSTMKSVVNSPT
                     YIKSILGRVSELMPNIKGRNYLYRATTPLEKRYIGNAKVFENSEVKRFFFKYKEKNIY
                     EYLLSNLYRDAQKNNYDYISKMQHIDVNTWLQGDILQKISKLSTAEQVELRVPFLYKD
                     VFDVAKNLRMEQKINKNNTKVLLREAFREIVPEHVVQRKKLGFPTPIRVWLKDSLGDI
                     VKETIYNSNVDEFIDKKYAIKLLDTHLKGHRDNSRKIWTIFTFCLWHQLFIEHKNVEY
                     "
     gene            complement(15898..17334)
                     /locus_tag="KRO40_002581"
     CDS             complement(15898..17334)
                     /locus_tag="KRO40_002581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBH2093398.1"
                     /translation="MICTIKPLKISIKKSTEPLIEFISDTTYKNKSSSYIKEVYFTRY
                     IGVDDSIDKYIEKIKNIDTYFFNNPTIPYIRLNNLKINFDKEQTDKMLKIFNIYNSSK
                     FNSWDLYNIDFPCKIENDTLNWTKKIAFKNTLDLFSTSMPNCTSSIIKNFAVKLLCWI
                     DYFLPKLFYNKVKTTISPKIVYFGNIKRQELFFLYFLSQLGCDILYINPNKDILDLYP
                     ECSKFSTLFELSRKTPNILEIPFERHITNINYSENTNKTSPTTNKPNSKNTLNNTNLT
                     SKKIVQDEEVELSYEDLAKLSASVVMIVVCNNENKPFKSGSGVVINNEGYILTNLHVV
                     NDGYSFLVRFENDDKVYTSYQIIKYHSDYDLAVIKVDRKCKPIPVKVSKKPVRGQKIV
                     AIGSPLGLFNTVSDGIISAFRDFETVQMIQFTAPISSGSSGGALLDMFGNLLGLISAG
                     YDDGQNLNLAVESSLVKIFANNFIEIVN"
BASE COUNT         6658 a         1876 c         2931 g         5986 t
ORIGIN      
        1 aaaaatgatg attttaaggc tatatagtgt tttattaata gtttaattta gtattatatt
       61 ttgcatatat ataacaaata gtttgcattt tcctaagatg tataattgga atataaatct
      121 tgtttactat gtacaaatgg tattgtatta tattaaatag aaaataagaa ctttaaacta
      181 taatattggt tctaaaatat aaggtaagga gttttttatg gatacgacga aaatagatga
      241 tataagcaag ttagatttaa ataatttaga cattaataag atggatatgg gaggtataat
      301 ggaaagtctg ctagaatggg ctactacaag cggagtaaaa cttataatag gtatacttat
      361 actttctatt ggatttaaaa taataaaaaa atttgtaaac catgttatgt tagtacttag
      421 taaaagagat attgatttaa ctttaagaag gtttttgaag tctcttcttt tgagtgtact
      481 taaagttgcc gttataatca ttgttctgga atattgggga atgagtttgt ccagttttgc
      541 tgctgtgata gcatcagcag gggtagcaat aggtttggct ttacaaggta gtctatcaaa
      601 ttttgctgga ggatttatta tactattgat tagacctttt aaagtaggag attacgtaga
      661 agcagcaggc catggaggaa cggttgaaca aataggactt ttttatacac aattggttac
      721 tccagataat aaacagatac ttatacctaa tggttctgta tcaaatgata gtctaataaa
      781 ctattcagca aagaatacta gacgagttga tttgactttt agtgtagggt atgaagatga
      841 tatactacat gttagaagag tacttaaaga tattgttaat aatcataaat taataataaa
      901 tgaaccagaa ccatttatag gagtagtaga acatggagat aatgctatta aatttgcaac
      961 tagagtttgg tgcaagacag aagattattg gacaatttat cttgatttac tagaagaggt
     1021 taaagttagg tttgacgaag aaggaattac gattccatat cctaaaatgg atttaacagt
     1081 aaaagaatta aacaaaattt aattttttaa tatagtgttt aaatttaaga atatcatata
     1141 gatatactta taaggtttgt aaaaaattaa taagtactgt tattttgtaa gtaaaaatat
     1201 aaaaaatggg cgtgtctcaa aatgaacttt ttagttcatg aggcactctt tttgtacgaa
     1261 ataaaatata tttttattat ttcaacaatg aaaaagatgc ttgtttctat tttgagacag
     1321 tataattttt atgtaacttt aattttagta aatataaagt tttaaaattg ataaaatagg
     1381 agaaattttt aatataaaag ggtaaataaa gggttcagag ggcataatat agaataaatt
     1441 aatatattta aggaggattt ttatgtgtaa aaaaacgtat ttattagtgg taagtatact
     1501 tatagcaggt ttattaactg catgtagtgg gagtccaact acggattcag gacaagcaca
     1561 agataataca aaaaaggagg caaatgcatc aaataacgct ttaaaagatg aaaaaaataa
     1621 tgaaaattta atggaacaag attttaaagt gccatacaca gatgcaataa acatatttaa
     1681 agataaatat aaggatgctg atatagtaga tttaagtctt gagagagatt taaataaatt
     1741 tgtttatact gtggaaggtg tagatgataa taatgaatat aagatgaaaa ttgatgctaa
     1801 tacaaaagat gtattagaag ataaaacaga aaagttggat tcagaagatt taaatggagt
     1861 tgctagaaaa gaaaaattag atttaaatga cataatgaca cctcaacaag ctatggaaat
     1921 tgcattaaaa gaacaaaatg gaatagttaa agaatggagt ttagacaaag atttagatgt
     1981 tactttttat aaaataagaa tagataaaga taaaaatgaa tatgacataa aagtagattc
     2041 taaaaaggga actgtattga aggtagaaaa agaagattag aagatttaaa ctatctttaa
     2101 aataatttct tttttgaata aattttgttt aaaatataac aagcagggta taaagagact
     2161 aaataactat tttaggagga gtacggtatg tcattgaaat cactaaaaat aaaagaaaat
     2221 ttatattggg taggttcact tgaccctgat ttaagagtat ttgacataat tatgtataca
     2281 ccttatggga ctacttataa ttcatatgta ttaaaaggaa cagaaaaaac agttttattt
     2341 gagacagtta aagataagca ttttgacaat tatattgaaa gattaaatga tttaaatata
     2401 gattttgaaa aaatagacta tattgttgta agtcatactg aaccagacca tgcaggaagt
     2461 gttgaaaagc ttttggattt agctaaaaat gcaaaagtag tagcttcaga aacagcaatt
     2521 aaatatctta aggaaatcgt aaacaaagac tttgaatatg ttgcagttac agatggagat
     2581 acattatcaa ttggggacaa aactttagaa tttttctctg tacctatgct tcattggcca
     2641 gataccatat acacatatat aaaagaggat aaaactcttg taacatgtga ttcatttggt
     2701 agtcactata gtaatgataa gatagtaaat acacttgatg aaaatgaaga aaaggattac
     2761 ttggatgctt taagatacta ttatgattgt ataatgggtc catttaaacc atctatggta
     2821 actgctatag aaaagataaa agatttagat atagatactg tatgtccagg tcatggtcca
     2881 gtattaactg aaaatcctag aaaaattata gacctttatt acaactggag tgtaaatgaa
     2941 caaataaagt tagaaaaaga agttacaatt tgttatgttt ctgcacatgg atatacaaag
     3001 attatggcag aagctataaa agcatatatt gaaaaaaata gcaactataa agtaaattta
     3061 tttgatgtaa tagagcataa gcaagaagat attttggcaa aaatagcagt atcacaaggt
     3121 gtattatttg gaacaccaac aatattagga gatgcgttaa agcctatatg ggatatatta
     3181 atatcgttaa acccagttct tcatggtgga aaagttgctt cagtatttgg ttcatatgga
     3241 tggagtggag aaggtataga aaatgctatg gagagaataa gtcagcttag aatgacagca
     3301 gtaaaacctt ttgctgttaa ctttaaacca tcaaatgaag agattgataa attacattct
     3361 tatacaggta aattcctaga taagttaaat tctacttttg gaagtaaaaa gaaaactaag
     3421 aaatttaaat gtgtaatttg taatgaagtt tttgaaggtg atagtgctcc tagtgtatgc
     3481 cctgtatgtg gagctaagga agaccaattt atagaagttg aagaagatga agttactttt
     3541 agaaaagata ctgatgaata tttcgtaata gtaggtaatg gagcagctgg tttttatgca
     3601 gcagatgcta taagaaaaag aaataaaact tgtaagataa ctatgatttc taatgaagat
     3661 gagttgactt actatagacc tgcactttct gatggtataa atgaagaact tggttcagat
     3721 ttctacatgg aagataaaga ttggtatgat aaaaataata tagtagtaat attaggaacg
     3781 aatgtagata aattagatga agtgaataaa actattatag tgaatgatgg agctattaaa
     3841 tttgataagc ttgtaatagc tacaggaagt agaaacttta taccaccaat taagggccat
     3901 gatttagaaa atgtgtttac tcttagaaat ataaaagatt tatatagtgt aaaagaagca
     3961 ctagaaaaat ctaagaaagt tgtagtgatt ggtggcggtt tattgggact tgaagctgca
     4021 tgggaattta gactaaaagg attagaagta gtagtagttg aagccatgga tagcatacta
     4081 tcaaaacaac ttgataaaga aggtagtaaa atattagaac aatgtgtaag agatacagga
     4141 atagatgtaa gattgggtgt agcagttgat ggtattgaag gtgatggaaa agctcaaaaa
     4201 gttgtattta aagatggaga tagtgtcgac tgtgatatgg tagtattttc aattggtgta
     4261 agagcaaaca ctcaaatggt tcaggataca tctgtaaaaa ttgatagagg tattgttgta
     4321 gataagacat tacagacaaa tgttaaagat atatatgctt gtggagatgt tgcacaagtg
     4381 ggaaatatta gtttagcaat atggccatct tcagtagaaa tgggaaaaat agcaggggca
     4441 aatgcaagtg gagataattt gacatttgaa agtgaagtat atccagtttc attagatgca
     4501 atgaatgtaa aagtatttag tattggtaat atacaaaatt ttgataaaga aatttcatca
     4561 aaagatgaag gtcaaagaat atataaaaaa ttatttatga aagatggttc attagttgga
     4621 gctatactta taaatgattt aagctgtact gttaaattga taagattaat atctgaaaaa
     4681 ggtgattttg aggatattat gaaggctgat atactataat ttaaatacat taaaataaaa
     4741 aggagttgtc ttaaaattga tttttttcta atcaaatttt aaattcaact ccttttttga
     4801 atttttatat aaaataacat ggaaatttta gtaatgtctg tggttacata cataggttta
     4861 attgtttttt atatggattg tctctggtat aataaattga attgtgtttg actgatagat
     4921 atttttattg aaagttaata cctgttatgc gataataagg acgtgttagg ggagttttta
     4981 taataacaat taatctcagt ttttgtgttc caatagtagc atcaacacat tctgatgtag
     5041 tagttctttt cttataaaaa ttagttacaa atatgcttgt aattatttga tatgtaaatt
     5101 taccaatatt ataaatgatg acctcgataa taaggagagt gaaaaataat ctatgaacga
     5161 aaatattttg attgtggatg atgaaaaaga aatagcagat ttaattgaag tatatttaaa
     5221 aaatgaaggt tttacagtat acaagtttta tacaggtaag gaagctctag aatgtattga
     5281 atctaaaaat ttggatatgg ctattttaga tattatgctt cctgatattg atggatttca
     5341 tatttgccag aaaattcgag aaaaatacta ttatcctatc attatgttaa cagctaaaat
     5401 tgaagatata gacaagataa tgggtttaac cataggtgct gatgattata taacaaagcc
     5461 atttaaccct ttggaagttg ttgcaagagt aaagacacaa ttaagaagat atatgcgata
     5521 taataattct tatgaacaac agtcgataat tgttaatgag tatgatatta aaggattgat
     5581 tatcaataaa gaaacacata aatgtagttt atttgggaaa gaagtagcat taacaccgat
     5641 tgaattttct attctttggt atttatgtga acatcaagga aaagtggttc cttctgaaga
     5701 attgtttgaa gctgtatggg gagaaaaata tcttgataat aataacacag ttatggctca
     5761 tatagggcga ttacgtgaaa aaattcatga accttctaaa aacccgaaat ttataaaaac
     5821 tgtatgggga gtaggttata caattgaaaa gtaaaaatat taaagtcaat cctgacttta
     5881 ctcaagtgag aaataaaatt tttatgagaa cagctttaat ggcatttata gccattattt
     5941 tcatatggat tttatattct tttatattgt atggtaagtt ttctatctgg atagtatcat
     6001 tctttgaaaa tgcttttcgt atggaatata aagctgcatt gaatttatat cagcagattt
     6061 tccgtaatag catggagctc ttcatgatac tagctatggt gattgtgttt tttataatat
     6121 tccgtgttta tttaaattgg tttacaaaat attttagtga aataaatcaa ggtattgact
     6181 ctcttatcaa agaagatgtt ggagaagtgg ctttatctcc agagttattg gcaatagaaa
     6241 agaaaataaa ctcaattaaa catatacttg aacaacgtaa atttgagaca caaatggcag
     6301 aacaacgtaa gaatgaactt attgtttatc ttgcacatga tttaaaaaca ccacttacat
     6361 cagttatagg gtatctgaca ctacttcgag atgaaagtca gatttctgaa gaactgcgaa
     6421 aaaaatattt atctatttcg ttggataagg cagagcgtct tgaagattta attaatgaat
     6481 tctttgaaat tacaaggttt aatttatcaa atatatcact tgaatacagt acagtaagct
     6541 taactcgtat gcttgaacaa ctaacatatg agtttaaacc tactttgatg agtaagaatt
     6601 taaaatatac actgaatgtt acaccaaata tgatgataag gtgtgatgtt aataaaatgc
     6661 aacgtgtatt tgataactta ttacgaaatg ctgtttatta tagttttgaa gatactacta
     6721 ttgaaataac agctgtacag gaggatgatt atataaagct taaatttatg aatcatagca
     6781 atacgattcc agaggaaaaa cttgagcgta tttttgaaca attttacagg ttggatacat
     6841 ctcgtaattc aaacagtggt agagctgggt tgggacttgc tatagctaaa gaaatagtgg
     6901 agcttcataa cgggacaata acagctcata gcgagaacaa tataattacc tttaaggtta
     6961 ttattccgat tgtaggaaat ttgtaagaat ttaagtataa aaaaatagga aattctttag
     7021 gataaataaa taaagagcac tcttgttatt gatataatta ctgtatcaaa acaagagtgc
     7081 ttttattttg atacagtaat tatatcaata gaaaaatgtg aaaatatatt atgtggaaca
     7141 gatgcaattg taagtgaagg ttgattggat ttgaaataga aaaagtattt taacatgttt
     7201 ctgtagattg tataaaaata aataaatcaa caaaggagaa tcaaagatga ataataaaaa
     7261 aattgcagtt atatttggtg gaaactcaac agaatatgat gtatcattac aatcagcttt
     7321 tgcagtactt gagaatttga atacggaaaa atatgatatt ataccaattg gaattacaag
     7381 ggagggtaat tggtatcatt atattggaga ttataataat atccagaata acacttggtt
     7441 tgaaagggat actgatataa ttccagttat tgtttcgcag aaccgtgtca aaaatggtat
     7501 tattgaattt ttaattcctg atgctgtttc tcagaatcat attccaaata gtgctattga
     7561 atcatgtgaa aatgatatta aatacactaa acttgatttt gtgtttcctg tactgcatgg
     7621 aaaaaatgga gaagatggaa cagtgcaggg gttatttgaa ttggcaggta tacaggttat
     7681 tggatgtggt actctttctt cagcattatg tatggacaaa gacaaatcac ataaacttgt
     7741 tcattcagaa ggtattaaag taccaaaatc aatattacta aaatactcag ataaatttaa
     7801 tgtggctgaa ctgtcaaaag acttaactta tccattattt ataaaacctg tgcgtgcagg
     7861 ttcatcattt ggtattagta aaatttataa aaaagaagag ttacaagtag cagtagactt
     7921 ggcttttgaa catgataatg aagtaataat tgaggaaaat attgatggtt ttgaggtagg
     7981 gtgtgcagtt ttaggaaacg atgacttact tgttggaaga gtagatgaaa tagaattgtc
     8041 aaaaggattt tttgattata cagaaaaata tacattgaaa agttcaaaaa ttcatatgcc
     8101 agctagaatt gatttggatt gtgagaaaag aatacaagag acagcaaaaa ttatttatag
     8161 aactcttgga tgttctggat ttgctagagt agatatgttt ttaactccat ctggtgaaat
     8221 tatttttaat gaagtcaata caattcctgg ctttacttct catagtcgtt atccaaatat
     8281 gatgaaaggt attggactgt cttttgaaga aatattggac aagataattg aggtgtacat
     8341 aaaatgatga ataatatttt attagataaa aataaagaag ataaaatgac aaatactatc
     8401 ttattgacta aagataaagt ttatgatggg aatctaattc tagtaaatgc ttttttacca
     8461 gttaaaacat cagaagatat agatttaatt cctgtagata caaggtttcc aagtattctt
     8521 atgaaacgtg aagctacaaa cattttacaa aatattttaa aaagtatatg tggaataaat
     8581 gaaatagtac ctgtaagtgg atatcgtact gcagaggaac aacaagatat atattcaagt
     8641 tctctgcgtg acaatggaaa agactttact aaaaagtttg tagcacttcc aaatcacagt
     8701 gaacatcaga cagggcttgc tattgattta gggttaaaga aagaagttat agattttatc
     8761 tgccctgaat ttccttataa tggtatttgt aatgagtttc gtaaggcagc actacattat
     8821 ggttttatag agcgttatca gtgtaaaaaa gaagaaataa caggaatatc tcaagaacca
     8881 tggcattttc gttatgtggg atatccgcat tctgagatta tcaataaaat gaatctcgct
     8941 cttgaagaat atatagaata tattaagaga ttttcgtata caaattgttt aaaaatagaa
     9001 gataaagaaa aaattataga aatcttttat gtgcctatcc atactaaaga agaagtgaga
     9061 atctctatac ctgaacaatg tgtatatcaa atatcgggta acaataagga tggttttatt
     9121 gtgacatttt ggagaaatag aaaggactaa gaaatggagg aacaagaatg attaggaata
     9181 aatcttatgc agggcttgat tattttagga ttatagctgc attacttata attgcaattc
     9241 atacatctcc attattatca tatagtaaaa tggctgactt tgtgttaact agtataattg
     9301 ctcgtattgc tgtgccattc ttttttatgc tatcaggctt ttttctaatt tcaacatata
     9361 attataattg taataaactg aaatcttttc taaaaaatgt attatttatt tacgggatag
     9421 ctattgtaat ttatattccc ttaaatattt acactggata tttttccatg aataatttag
     9481 tgcccaatat tattaaggac attgtatttg atgggacttt atatcattta tggtatctac
     9541 ccgcatcaat tattggtgca agtattgcat actttcttgt aaaaaaacta ggtttaaagt
     9601 actcactagt aatcactatt gttatttatg taattggtat gtttggtgat agttattatg
     9661 gttttttaga aaaaatacca ctattaaaga atttatatgg gtatattttt gaagtatcag
     9721 attatacacg aaatggtata ttttttgcac ctgtattttt catacttggt ggaataatat
     9781 ctaataaatc taattatatg tcaactaaaa atagcttgat tggatttctt atatcattct
     9841 tacttatgtt atgtgaggga atgtttttac ataaactagg ggtacagcgt catgatagca
     9901 tgtatattat gttattgcca tgtatgtatt tcttatttac agccttaaca tttttgaaag
     9961 gttctcgagc taggttattg cgaacatcat cattaattat ttatattata catcctatga
    10021 tgattgttgt tattcgtatg ttttctaaaa tattcggaat acaaactgtc ttggttgaca
    10081 atagccttat tcattatata gtggtaagta tagcatcttt tatagcttct ataattatta
    10141 tattgattct taaacatcta aaaaaagact tgaaaggaga acataaggta aataccaata
    10201 gagcttggat tgaaattgat ttaaataatt tggaacataa tgtaaatatg atacaaaaag
    10261 ctatgccaga agattgtgaa ttgatggcag ttgtaaaagc taatgcctat ggtcatagtg
    10321 cttttgaagt agcgacttgt gcaaaccaaa taggtgtaaa agcatttgca gtagcaacaa
    10381 tagatgaggg gattgattta cgtcgatatg gaatactagg agaaatattg attcttggat
    10441 atactaaccc aataagggca aaggaacttc ataaatacaa tcttacacag agtgttattg
    10501 accttaatca tgctatctct ttaaacaaac agaaatacaa cataaaatca cacattaaaa
    10561 ttgatacagg tatgcacaga ctgggttttg atgttaatga tgtgaggtca attttaaagg
    10621 catttaaatt aaaatactta gatatatgtg gcatatttac acacttgtgt gtttcagata
    10681 gtctgaaaga tgaagatgta gactttacaa ataaacaaat tgaatgtttt tataagttaa
    10741 ttgattttct gttaaaaaaa ggtataaaaa ttcctaaagt acatattcaa agtagttatg
    10801 gtttttttaa ttatcccaat cttaagtgta attatgtaag aattggaatt gcattatacg
    10861 ggatattaag ttctccaaat gatacgacta aattgcaact tgatttacga cctgttttat
    10921 ccttaaaatc acaagtaatt cttattagaa aaatacaaaa agatgatagt tttggatatg
    10981 gaagagtctt tattgcaagc agagatagcg taattgctat attatctatt ggctatgccg
    11041 atggtatacc tagaaattta tcctgtggaa aaagttacgt aataataaat gattgtagag
    11101 cagcaatagt gggtcgaatt tgcatggacc aacttgctgt tgatattaca gatataccta
    11161 atgtagaagt tggtaatacg gcaataataa taggaagaga taatttagct gaattatctg
    11221 cttctgaagt tgcaaataac tcatgtagta tatcaaatga attattgagc agagtaggaa
    11281 gaaggttaaa tgttataaag aagtaactca attaaatagt aatatttgtt atactgtgta
    11341 atttatttta ctctgactag acatttttag taatattatg tctaatatat attttttata
    11401 acttacatga caatttaagt tataaaaagg tgatgtttca gatttttatt ttgaaacatc
    11461 accttttttg ttataatata taataaaata attatacctt aactgtaaac ttatatagat
    11521 tatttacttt ttaatattag attcattttt tgagattggt atataataaa catatagagt
    11581 atataataat agttaaagtt aaaaaagggg aaaagcaata tgcagtatat acaagaacta
    11641 cttgatttga ctcaaaatta ttgggtgtta gccacaataa tcggcttatt aagtgcattt
    11701 atagaaagct ttataccagc cttaccactt gttgctatag ttacagcaaa tgctgcaata
    11761 caaggattat ttattggatg tttgttatca tggattggct caggacttgg gacaacttca
    11821 ttattcttat taataagcag atttaatgat agtaagcttt ttaataagtt gagaaatagt
    11881 aaaactgaaa aagcaataag ttggatggat aaacagggat ttaagttatt atttatagcg
    11941 tatgcctgtc catttatgcc tggttgttta gttactatcg catcagcttt tggtaaaaaa
    12001 gatttaaaag attttgtgcc agcaatgttg gcaggaaaat ttgtaatgtt tatagttata
    12061 agttacgtgg caagtgatat agaaggtttt ataacaagtc ctttaaagat agcatcattt
    12121 atattattgg tgtttttgtc atggaagatt ggaaatagag taaataaaaa tcttgaaaat
    12181 cataattatg atttccatca taaaaaacat cacaatgata aagatgataa aatgatttag
    12241 cttgtacgaa ataaaacgta tcttaaaatg atttagtact aaattatttt aagatacgtt
    12301 ttattttttg tattaaggta caaaattttt agttcttttg taaactaaaa tatataaaac
    12361 ttatttatac ttagttcaaa atattgttat ttattttttc tacaactata ataaaatata
    12421 aaattgatat ccaatcaaaa aaataactat gaaatttaat agcttagata tgaatttttc
    12481 tgtttttgag ttagttttta taggtagtaa agaaatgttt atggtaatgg gataaaacaa
    12541 ttcaatacct tctttagtaa taaggtcaag acacaagtga gatagatatc ctattataaa
    12601 cccactggac aaacatgaga aaactatatt attgttagtg aagattgtca gagatttaaa
    12661 aaaactataa ataagtaata aggcaattag actgtgagta aaccctctat gtctaaacct
    12721 acttccaaat aatttgtata ttaacataaa ttttttactt atgtaagaac ctctcatatc
    12781 tatatctgga aataaagaac ctaaatatgc aaaataaata taaattataa ttaatactat
    12841 tttatatgca atatcgtatt taactaggta cagattgttt ataaagggga gtatcaaaag
    12901 tgcgaatata taacctcccc tttcatgtgt ttcttttatc atataaaaat cctcctgaat
    12961 cgtcactata aacattatat tggtaaattt agactatctt ttattatatt atatagcaaa
    13021 cataagtttt tttcaaaagg attttaatat ttaattaatc ttgagatttt aaatttttgt
    13081 aattttctaa agcaccattc caatttacta cattaaacca gttgtcaatg tattcatttc
    13141 ttctattttg atattttaaa tagtaagcat gctcccaaac atcaagtcct attataggag
    13201 ttaggttttt acttacaggg ctatcctgat ttggagtagt cataatagat aatttgccat
    13261 ctttagtagc tataagccaa gcccaaccag aaccaaagac atctaaagca gatttttgga
    13321 actcttgctt aaatttttca aaagaaccaa agtctctatc aatagcttct tttaaagatt
    13381 cagaaggtat ggttttttct ggtgtcatta tatcaaaaaa gaatttatga ttataagctc
    13441 cacctgcatt atttcttaca gttgtagcaa tatctttagg taaagaatct aaattttgca
    13501 ataattcaca taaagaataa ttataaagct caggatattt ttcaagagca gcatttaatt
    13561 tatcaacata agcttgataa tgcttatcat gatgcagttt cattgtttct ttatctatat
    13621 aaggttcaag tgcatcatat gcataaggta atggtttaac cttaaatttg ttattttcag
    13681 gtgtaaaagc aaatgaagtt atgcactgtg agattataaa taaagacata ataactggta
    13741 ttaatatttt tttcttcata aaaatcacct cctaatatag tatttctaga aataaaaaaa
    13801 atatgaaata ttaacagata atttataaga atttaatagc aatttcattt taaattgaat
    13861 aagttttaaa gccaaagaca aaactatgaa atatagaata agactaaagg acagaaagga
    13921 attttgatta tatggacggc aatatttcaa tttattataa aggtgatata tctaaaaaag
    13981 aagatattaa atttaaaata aaagaatctg taaataatac aagactttct agtagaatag
    14041 agtataagga tgaggaaaaa acttttgatt ttgaaagatt taatgtaatt gatgctattt
    14101 atggaaataa accatttgaa aaagatggaa aagttattgt ttttaatgga aatatatata
    14161 actatcatga aataaaagaa gaattaatta aaaaaggaca caattttact acaaatgatg
    14221 atattgaagt cttattagca tcttatatag aatttggtaa gaattgtgta cataagatta
    14281 aaggaatgtt caactttata atctatgata gagaaaatga aagtatattt ggagcaagag
    14341 atttatttgg gataaaacca ctttattata taaataagga aaatgcaata attttttcct
    14401 cagagtataa gtttttactt gaatatatga aaaatttaaa tataaatgaa agaagcttac
    14461 aaagttattt ttcatttcaa tatgtacttc ctgaagatac tatgatacaa ggaataaggc
    14521 tgataccagc aggtcactat tttagggtag aaaatggtat actatcttta aagagatata
    14581 ataaacttga gtttagaagt agtacaaaat ttttttatac taaaaatcac ttaggcaata
    14641 gagatgtgaa tgaggatgat ataagaaata tagtagtaga ttcaatagta actcatatgg
    14701 aagaggagaa agaaattgga acatttttgt ctggtggaat agattcatct attataacta
    14761 ctgtggcttc acaaattaat ccaaatataa aatctttttc tgcaggcttt agtgtcaaag
    14821 gatatagtga attagaagta gcaaagaaaa cagctgataa gttaggtata gaaaatatcc
    14881 agattaatat aacacaagat gaatatataa aatcattacc gaatgtaatt tattctttgg
    14941 atgaccctat agcagaccct tcagaagtag gtctttattt cttaattaaa gaggcaggta
    15001 aacatgttaa agtagcattg tctggagaag gagcagatga attatttgga ggatataata
    15061 tatataaaga gtatagtact atgaaatcag ttgtcaattc acctacttat attaaaagta
    15121 tattaggaag agtttcagaa cttatgccaa acataaaagg aagaaattat ctttatagag
    15181 ctacaacacc attagaaaaa agatatatag gaaatgcaaa agtttttgaa aacagcgaag
    15241 taaaaagatt cttttttaag tataaggaaa agaatatata tgaatacctg ttgtctaatt
    15301 tgtatagaga tgcacaaaaa aataattacg attatataag taaaatgcaa catatagatg
    15361 tgaatacatg gcttcaaggc gatatacttc aaaaaattag caaactttct acagctgagc
    15421 aggttgaact tagagtacca tttttatata aagatgtatt tgatgtcgca aaaaatttaa
    15481 gaatggagca aaaaataaat aagaataata caaaagtttt acttagagag gcgtttagag
    15541 aaatagtccc agaacatgtt gttcaaagga aaaaattagg atttccaact ccaataagag
    15601 tttggttaaa agattctcta ggggatattg taaaggaaac tatttataat tcaaatgtag
    15661 atgaatttat agataaaaaa tatgcaataa aacttttaga tacgcatctt aaaggtcata
    15721 gagataattc gagaaaaata tggactatat ttacattttg tctatggcat caattattta
    15781 ttgagcataa aaatgtcgag tattaatact tttttcaata ttaatcagag ggcaaaagca
    15841 tgcaatgttt tcaccctctt gattattatg gaataggata agtagaattt tgattgatta
    15901 gtttactatc tcaataaaat tattggcaaa tattttgaca agactacttt caacagctaa
    15961 atttaagttt tgtccatcat catatccagc ggaaatcaat cctagtaagt ttccaaacat
    16021 atctaaaaga gctcctcctg aactaccact agagattgga gctgtaaatt gtatcatttg
    16081 aaccgtttca aaatcacgaa aagctgaaat aattccatct gaaactgtat taaaaagacc
    16141 tagagggctt ccaattgcaa ctattttttg acctctcaca ggttttttac tgactttaac
    16201 aggtattggc ttgcattttc tatcaacctt tatcacagct aaatcataat ctgaatggta
    16261 ttttataatt tggtaagatg tataaacttt atcatcattt tcaaatctaa ctaaaaatga
    16321 atacccatca ttgactacat gaagattcgt aagtatataa ccttcattat ttattactac
    16381 tccagaaccg ctcttaaacg gtttattttc gttattgcac acaacaatca taacaacaga
    16441 agctgataac tttgcaaggt cttcataaga aagttctact tcctcatctt gtacaatttt
    16501 tttagatgtt agatttgtgt tattaagtgt atttttagag ttaggtttat tcgtagtagg
    16561 agaagtctta ttggtatttt cactgtaatt tatatttgta atatgccttt caaaaggtat
    16621 ttctaatata tttggagtct tcctagaaag ttcaaataga gtagaaaatt ttgaacattc
    16681 aggatataaa tcaagaatat ctttatttgg atttatatat aaaatatcac acccaagttg
    16741 tgataaaaaa tataagaaaa aaagttcttg ccttttaata tttccaaagt atactatctt
    16801 tggtgaaata gtagtcttca ccttgttata aaataattta ggtagaaaat agtctatcca
    16861 acacaaaagt ttaactgcaa agtttttgat gatagaggat gtacaatttg gcatacttgt
    16921 ggaaaataaa tctaaagtat ttttaaatgc aatcttttta gtccaattta aggtgtcatt
    16981 ttctatttta catggaaagt cgatattata taaatcccaa ctgttaaact tagaactatt
    17041 ataaatatta aaaattttaa gcatcttatc tgtttgttct ttgtcaaaat ttatttttag
    17101 attgtttaat ctaatatagg gaattgtagg attattaaaa aaataagtat ctatattttt
    17161 aattttttct atgtatttat caattgaatc atcaacacct atatatcttg taaagtagac
    17221 ttctttaata tatgaagaac tcttattttt ataggtagta tcagatataa attcaattag
    17281 aggttcagta gactttttta ttgaaatctt taatggttta atagtacaaa tcatattttt
    17341 tctcctataa taagatgata taatctatta taaaacaact taaaacaata tagtacaata
    17401 attttgtagt ttcaaaataa aatatgtact tgtttatata aatgatatat a
//
LOCUS       DAEQCW010000078        17145 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.078, whole genome shotgun sequence.
ACCESSION   DAEQCW010000078 DAEQCW010000000
VERSION     DAEQCW010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17145)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17145)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17145
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.078"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            140..1045
                     /locus_tag="KRO40_002582"
     CDS             140..1045
                     /locus_tag="KRO40_002582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH2093399.1"
                     /translation="MKNSNFNILAFDGGGLKGALSISILERIVKEYPNLLNNINMFGG
                     TSTGSLIALGLAYGVSPKEIKELYSIENSKYIFNKSYAEILRPKYENKNLKEVLLSIF
                     PEELELKDLNKLVMIPSFYIGNEENAWKPVFYNNMPNSFTKTSKVVDVAMASSAAPVF
                     FPTYNRHVDGGIIATDPSLACIIHAIDSGFKLKNTRLFSIGTGYVYNSIKADTTEWGA
                     IDWIINKEPDLPIISITLEGNSQMSQLFSQKLLGDNYYRLNPKMEKDVAMDDCDALEY
                     LMSLGENCDIKDAFGWIKKKSFYRN"
     gene            1169..2122
                     /gene="msrA"
                     /locus_tag="KRO40_002583"
     CDS             1169..2122
                     /gene="msrA"
                     /locus_tag="KRO40_002583"
                     /EC_number="1.8.4.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="HBH2093400.1"
                     /translation="MIKLATFAGGCFWCMVKPFDKYDGVIKVVSGYTGGHVENPTYQE
                     VCSGTTGHLEAIQITYDDDIISYDELLNIFWKQINPTDDGGQFGDRGTQYKTAIFYHD
                     EEQKNIALESREHLENSKIFDSKIVTDIIPATKFYEAEENHQDYYKKRPLNYNMYYKG
                     SGRYNFVKSHWDGNNINREELKKTLTPIQFEVTQNDMTEVPFENEYYDNNKEGIYVDI
                     VSGEVLFSSKDKFDSGCGWPSFSKPVIDKSIIERSDFSQGMYRVEVRSAKGNSHLGHV
                     FDDGPKELGGLRYCINSASLKFIPRENMEALGYGEYLKLFE"
     gene            2275..3405
                     /locus_tag="KRO40_002584"
     CDS             2275..3405
                     /locus_tag="KRO40_002584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093401.1"
                     /translation="MNLKDFNGKRLKSARIFRAKTIEQLSKETKINKKDLKAFEENKY
                     VPNIENTLKLSNILNFPKEYFYKNENINIVVEDSHFNPQSKLPRVEEISYREKIIIIH
                     KIYSFMENYIKFPKENLPNRKVMSDININDIESLAYKTREFWDLNSTPIVNMVSLLES
                     KGIIISGMNVDRKGATIFTQKQRISKESKYLISLGNDKKSASIRNYTLACELGYIISS
                     ELRIPSKQFSEDEYACAFLLPKESFLKDLTHPEDLDYYVELKKKWIVPISAMIFRAYN
                     LEKINYKKYNYLMNEMDKKGWLIEEPLDKMKGSSPTYLKRAVELLIENKIMSVNSIVS
                     SLEEFRINLYPEDLELLMGLKKGLLSQEVNKKSKVIKFDGKK"
     gene            complement(3522..4490)
                     /locus_tag="KRO40_002585"
     CDS             complement(3522..4490)
                     /locus_tag="KRO40_002585"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HBH2093402.1"
                     /translation="MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSK
                     AQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRP
                     TIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL
                     RRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSTYSNLDLP
                     SIVEKNKKTGISIINGKDCTEFGIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNV
                     FAGVPCVIGKDGIEEIIEINMTEYEQNEFNKSCSVLREYIALSKTL"
     gene            4824..5012
                     /locus_tag="KRO40_002586"
     CDS             4824..5012
                     /locus_tag="KRO40_002586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093403.1"
                     /translation="MNYHTKEELVEALRVVSSSIINCGKGQKKFSEETSHHTRFKNII
                     EVMYISKSLIMDEISKRD"
     gene            5272..6471
                     /locus_tag="KRO40_002587"
     CDS             5272..6471
                     /locus_tag="KRO40_002587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanyl-tRNA editing protein AlaX-L"
                     /protein_id="HBH2093404.1"
                     /translation="MEKLYYTNQYIRDFTAEIIEIKEVENKYHVLLDKTAFFPGGGGQ
                     FGDLGKIENDDVINVYEDGKKIYHVLDKKPIKIHKVKCSIDWDRREDGMHQHFGQHVL
                     SGCFFKTFNANTTGFHLGNEYSTVDIEGNLEEDKIREIELFANEIIRQNIQVETLLPT
                     KKELKKIWLRRDLPNTDEEIRVIKIGDLDTNACCGVHPKSTGELRMIKIKKWEKHKSS
                     TRIEFLAGKRAVDEVLKRDIYLTKICRYLSCSEEDAINGIVNLNSKVEEALIKKRRLE
                     EVVSTYQVKEMIEKANKVGNISVIKKIYDDEDLKYVNKIANKIAEYENSIALLAVKFN
                     DKINLVFACSKNLKDINMGVLLKDAISLIDGKGGGSKVLAQGGGKNNGNLEATLDYAF
                     MKIEKTL"
     gene            6523..7026
                     /locus_tag="KRO40_002588"
     CDS             6523..7026
                     /locus_tag="KRO40_002588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093405.1"
                     /translation="MEQQKDYIELYENEELIEIREARMDDLDTIAKFNYNLAKETEGK
                     ELDMDVLTKGVKALLLDERKGKYHVYTVFDKVVAQIMYTYEWSDWRNGNFLWIQSVYV
                     DKEYRRKGIFNYLFNYIKNICDKDENIVGMRLYVEKENINAKATYESLNMYECDYNMY
                     EYEVVHS"
     gene            7133..7450
                     /locus_tag="KRO40_002589"
     CDS             7133..7450
                     /locus_tag="KRO40_002589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093406.1"
                     /translation="MGVLKGMFYVFLFLDLVSIFCFFFNKGKIASNKIVFNAIGVLTF
                     VLCFMLFSYYPNNNLIGKFIASLFFIFGVAGVMLKEKNFLYARLLLTVVIVFSTLRLF
                     VIQ"
     gene            7608..8567
                     /locus_tag="KRO40_002590"
     CDS             7608..8567
                     /locus_tag="KRO40_002590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH2093407.1"
                     /translation="MIESKKSEKLLLSIIYIIFLVYILMIIRIILFRDVPIYAIFKGT
                     FRNVNLIPFYTIYQFIVDSNLDFMKATVNIIENIGIFIPMGIFLPIVCKNLNKKTIII
                     VIILVSLAFELTQYIFALGSSDIDDVILNSLGGIIGINIYINMNKLFPSDINRFKAII
                     GTSLVLGVIGLGVISKNYHNLLTFKFRPDRKISKILIEENREIIKDINKDTVDIVGTF
                     ESFKKGIITIKAGSNNKVKRPENLIDSDGNIRIYLNENTKLVSYIITKESKMDIVKYE
                     EFDVKNLDLLRRYDTINVWIDKENQPKDKHGIMASKLLIGLYE"
     gene            8682..9467
                     /locus_tag="KRO40_002591"
     CDS             8682..9467
                     /locus_tag="KRO40_002591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093408.1"
                     /translation="MEIIKYILYFFIYSFLGWTVESIGCSIASKRIINRGFLNGPICP
                     VYGFGAVIVISLLGRFNNVVIVFLLGMILTTILEYFTGFILETLFHAKWWDYSDRKFN
                     IKGRVCLKNAIYFGVMSVLIIRFIHPFIKYFVSIIPYRILISMAIITTLWTILDLIVT
                     IITLKKLDIKLNLLDDIITDLNDINVKLDKFDRGEIQALFKTINNDELEVREKINKIN
                     SKLDRIESNIILQKRVIKAFPHIKHKKQQEQLEHFKKIINEKR"
     gene            9759..11078
                     /locus_tag="KRO40_002592"
     CDS             9759..11078
                     /locus_tag="KRO40_002592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBH2093409.1"
                     /translation="MSEITSQMISTEEKKYVAKTQKIPYYPVAFKSGDGAMLYDYEGN
                     EYVDFLASAGSANVGHGNKEISQAVKEQMDDITQYTLAYFHSDPPVKLAEKLVEIAPG
                     DNDKKVLYSATGSACIDAAIKLARGYTGRTKIISMCESYHGSTYGAISISALSTNMRR
                     KMGPLLPEVYHFHYPDKNRTAKECLDEIEYAFAHYLPAEEVAAIFIEPIAGDAGIIVP
                     PVEWVQGLSKICKENGILLVSDEIQQGMGRTGKWFGIENFGVEADLIVLGKSVGGGLP
                     LGAVVGRTEIMQSLDAPAHLFTLAGNTTVCVAALKSIEIIEKENLLQKSIEMGDYIKA
                     GFEKLKEKYDIIGEIRGIGLSIGVDIVKGKGSNEKHPDATAKICYRCIQTGLIMIFLG
                     QSTLRVQPPLVITKEQVDKAMNIIDSAIDDYLNGRIGDEVYEVTQGW"
     gene            complement(11153..11581)
                     /locus_tag="KRO40_002593"
     CDS             complement(11153..11581)
                     /locus_tag="KRO40_002593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093410.1"
                     /translation="MKDNNNTNKTIQFGEKKASLENNIQKNKNIKLDNTHKVIPYPKN
                     RKKDDKKKGNKKKNTNTSKVNKNNYGHSFFNNKYKYKRKPYVIALYTVILILLAILII
                     TKLTDSTNKGNYSRNTVSDTHKNDIRNIVFNESNNFLICG"
     gene            complement(11672..13048)
                     /gene="hydG"
                     /locus_tag="KRO40_002594"
     CDS             complement(11672..13048)
                     /gene="hydG"
                     /locus_tag="KRO40_002594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydG"
                     /protein_id="HBH2093411.1"
                     /translation="MFINHELINSLLEDAKNSTSDDIEKVLDKADRREKLSYKDIATL
                     LEVEDKKQLDRLFSIAGQIKNEIYGNRVVLFAPLYVSNYCVNECVYCGFSKCNKFKRK
                     KLTMEEIKEEVKILEKMGHKRLALEAGEDPKNCDINYILDCLDAIYSTYNENGNIRRV
                     NVNIAATSVDEYKLLKEKGIGTYILFQETYHKPTFIKMHGQSIKNDYYYHLTAFDRAM
                     EAGVDDVGAGVLFGLSDPKFEVLGLMMHNEHLEEKFGVGFHTISFPRLKKAEGMSLED
                     FPHLVSDDMFKKIVAITRLAVPFTGIIMSTRETAEMRNELLKYGVSQISAGSLTGVGG
                     YKAYEDGDNTEQFEVGDHRSPVEVLKELITDGYIPSYCTACYRKGRTGDRFMSLAKSR
                     QIHNVCTPNALTTLNEFLIDYGDEELKIMGKKLIAEEIGKIEREDIRNIVSNNMTALE
                     RGERDLYL"
     gene            complement(13049..14134)
                     /gene="hydE"
                     /locus_tag="KRO40_002595"
     CDS             complement(13049..14134)
                     /gene="hydE"
                     /locus_tag="KRO40_002595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydE"
                     /protein_id="HBH2093412.1"
                     /translation="MTKNKIKYFIDKLYSINSLSFDELLYLIENIDNEEYNFEQNLRN
                     YLYKQASDMRNKHYGNRVYLRGLIELTNYCKNNCYYCGIQSSNKNIIRYRLSLDEILE
                     CCDIGYKIGYRTFVLQGGEDAYFTDDKICEIVSSIKNKYEDCAITLSLGEKSYDSYKK
                     YFLCGADRYLLRHETATDSHYKKLHPPNIELRTRKECLKNLKEIGYQVGAGFMVESPF
                     QNNEDLVRDLLYLKELNPHMVGIGPFIPHHDTIFKDYKHGDLEKTLLMLSITRLLLPK
                     VLLPATTALASINPSGRNAGLLAGCNVIMPNLSPQEFRKQYSLYDNKAFTGQEACEYH
                     QSLEENIKSLGLEVDYSRGDNIEWRRL"
     gene            complement(14170..15378)
                     /gene="hydF"
                     /locus_tag="KRO40_002596"
     CDS             complement(14170..15378)
                     /gene="hydF"
                     /locus_tag="KRO40_002596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster maturation GTPase
                     HydF"
                     /protein_id="HBH2093413.1"
                     /translation="MSLNSTPQSVRVHIGLFGKRNAGKSSIINAITNQSAAIVSDIAG
                     TTTDPVFRPMEILPIGPCVLIDTAGLDDVGELGELRIGKSLDVLEKTDIALLVVDCQI
                     GISQEDLSLIEKFNDKNIPHILILNKIDTIKNQSEILNLTKNKVKCPVVSVSSTDKIG
                     IENLKNEIIKVLPKDSTEFKLVSDLIEPNDLVVLVVPIDKAAPKGRLILPQQQVIRDI
                     LDNGAISIVTKEDSLKETLSNLGKKPKLVITDSQVFPQVDKDTPKDIPLTSFSILFAR
                     QKGDLKELINGAYALENLKDGDKILMAEGCTHHRQTDDIGTVKIPNMIRKKTGKNITF
                     EFSSGVSFTEDINKYALVVHCGACMMNRAGMLSRIEKAKSFNVPIVNYGVLIAYVKGI
                     LERSLELFNY"
     gene            complement(15393..15644)
                     /locus_tag="KRO40_002597"
     CDS             complement(15393..15644)
                     /locus_tag="KRO40_002597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-only hydrogenase system regulator"
                     /protein_id="HBH2093414.1"
                     /translation="MKKVAVISAILEEPKECQFKFNEVVSGFKGIIKGRMGIPCEEEG
                     VSIVCIAVVGEMDTINSLTGKLGNIPHVSVKTSISKKEV"
     gene            complement(16025..17065)
                     /locus_tag="KRO40_002598"
     CDS             complement(16025..17065)
                     /locus_tag="KRO40_002598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HBH2093415.1"
                     /translation="MNLNLTNTINLMKKYLDIPSPAGYTENAVLEIKKDFENLGLDTI
                     LTKKGALIATLPGEDDSNQITISAHMDTLGAIVKEISSDGTLKYHKVGGGCWAAIEGE
                     NCTVITRKGKKIRGSVVFKYASTHIYGQTKAATERNEETMIIRLDEKVFTKQDVLDLG
                     ISVGDFVCLDHRFEATESGFIKSRYIDNKSAVAMVLEICRYFKENNLTPKHTTNFYIS
                     NYEEIGHGVSKCLPEKTKEFVAIDIAPTGPSQTSSEHGVTIVAKDNLSLYDFNLRNKL
                     VDVAEDNNLDYAVDVFTFYGSDASEAIRWGEDVQIACVGPGTNNSHHYERTHIEAIEN
                     TLKLLINYMLKE"
BASE COUNT         6409 a         2060 c         2655 g         6021 t
ORIGIN      
        1 gtattaaagg tttgaatgta acttaaatat taaaagagga acattgtaat atgtaacttg
       61 cataaaatat atatactata gtgaaattat tttgattaaa atttaaaata taaggtgttt
      121 tatgtggggg tatatgtata tgaaaaattc taattttaat atattggcat ttgatggtgg
      181 tggattaaaa ggggcattga gtatatccat acttgagagg atagtaaaag agtatccaaa
      241 tctattaaac aatataaata tgtttggagg tacatctaca gggagtctaa ttgcactagg
      301 gcttgcgtat ggtgtaagcc ctaaagagat aaaagaactt tactcaattg aaaattcaaa
      361 gtatattttt aataaaagtt atgcagaaat actcagacca aagtatgaaa acaaaaactt
      421 aaaagaagtt ttattaagta tatttccaga ggaactagaa ttaaaagatt taaataaatt
      481 agtaatgata ccaagttttt atataggaaa tgaggaaaat gcatggaaac cagtgtttta
      541 taacaatatg ccaaattctt ttacaaagac tagcaaagtt gtagatgtag caatggcaag
      601 tagtgctgct ccggtatttt ttccaacata taatcgtcat gttgatggag gaataatagc
      661 aactgacccg agtttagcgt gtataattca tgccattgac agtggattta aacttaagaa
      721 tacaagactt ttttcaatag ggactggata tgtatataac agtataaagg cagatactac
      781 tgaatgggga gctattgact ggataattaa taaagaaccc gatttaccaa ttatatctat
      841 taccttagaa ggaaattctc aaatgagtca gttattttct caaaaacttc ttggagataa
      901 ttactataga ttaaatccta agatggaaaa agatgtagct atggatgatt gtgatgcatt
      961 agaatatcta atgtctttag gagaaaattg tgatataaaa gatgcttttg gatggataaa
     1021 gaaaaagagc ttttatagaa attagattca atttgcaatt gtatttttac acatgatttc
     1081 attgagtagg taaaaataat aaaatgcaga ttattaagtt acttcttagg gaataaataa
     1141 agtataattt atttaaggag tgatgaaaat gataaaactt gctacttttg caggtggatg
     1201 tttttggtgt atggtaaaac cttttgataa gtatgatgga gttattaaag tagtttctgg
     1261 atatacaggt ggtcatgttg aaaaccctac atatcaagag gtatgctcag gaactactgg
     1321 tcatttagaa gcaattcaaa taacatatga tgatgatata ataagttatg atgaacttct
     1381 aaatatcttc tggaaacaga ttaatcctac agatgatggt ggacaatttg gtgatagggg
     1441 aactcaatat aagactgcta tattttatca tgatgaagaa caaaaaaata tagctttaga
     1501 gtcaagagaa catctggaaa atagtaaaat atttgatagt aaaatagtga ctgatataat
     1561 tccagcaact aaattctacg aagcagaaga aaatcatcag gattattata agaaaagacc
     1621 attaaactac aatatgtatt ataaagggtc cggaagatat aattttgtaa aaagtcattg
     1681 ggatggaaac aatataaata gggaagagtt aaaaaagact ttaactccta tacaatttga
     1741 agttactcaa aatgatatga cagaagtacc ttttgaaaat gaatattatg acaataacaa
     1801 agagggaatt tatgttgata ttgtaagtgg agaagtgtta ttttcttcaa aagataaatt
     1861 tgattctgga tgtgggtggc caagtttttc aaagccagtt atagataaat ctatcattga
     1921 gagaagtgat ttctcacaag gtatgtacag agttgaagta agaagtgcta aaggaaattc
     1981 tcatttaggt catgtatttg atgatggtcc aaaagaactt ggaggtttaa gatattgtat
     2041 aaattctgct tctcttaaat ttataccaag agaaaatatg gaagctttag gatatggaga
     2101 atatttaaaa ctttttgagt aattaggaat atttattata aacttatcta aaaggtgaaa
     2161 atctaaaaaa atattttcac cttttgtttt tttgtcaata gtatgataaa ttattaattg
     2221 taatcttatt tataccaata gattaagaat ttaattttga aagagagaaa acaaatgaat
     2281 ttaaaagact ttaatggaaa gagattaaaa tcagctagaa tttttagagc aaagacgata
     2341 gaacagttgt ctaaagaaac taaaataaat aaaaaagatt taaaagcttt tgaggaaaat
     2401 aagtatgtac caaatataga aaatacatta aaattatcta atatattaaa ttttccaaaa
     2461 gagtattttt ataaaaatga aaatataaat atcgttgtag aggatagcca ctttaaccct
     2521 caatctaaac tacctagagt agaagagatt tcttatagag aaaaaataat tataatacat
     2581 aaaatatatt catttatgga gaattatatt aagtttccaa aagaaaactt gccaaataga
     2641 aaagtaatgt cagatattaa tataaatgat atagaatctc ttgcatataa gactagagag
     2701 ttttgggatt taaatagtac tccaatagta aatatggtaa gtttgttaga gtctaaaggg
     2761 attataatat caggtatgaa tgtagataga aaaggggcaa ctatctttac tcaaaaacag
     2821 agaattagta aagaatctaa atatctaata tctctgggta atgacaaaaa gtcagcatca
     2881 attagaaatt atactttggc atgtgaactt ggatatataa tatcaagtga attaagaata
     2941 ccaagtaagc aattttcaga agatgagtat gcctgtgcat ttttattgcc aaaagagagt
     3001 tttttaaaag atttgactca tccagaagat ttagattatt atgtagaact aaagaaaaaa
     3061 tggattgtac ctatatctgc tatgattttt agagcatata atctagaaaa gataaattac
     3121 aaaaaataca attatcttat gaatgaaatg gataaaaaag gctggttgat agaagaacca
     3181 ctagacaaaa tgaaaggttc aagcccaacg tatttaaaaa gagcagttga attattgata
     3241 gaaaataaaa taatgagtgt aaatagtata gtatcaagtt tagaggaatt tcgaataaat
     3301 ctttatccag aagacttaga attattgatg ggattgaaaa aaggattgtt atctcaagag
     3361 gtaaataaaa aaagtaaagt tataaaattt gatggtaaaa aataggttta tattttagta
     3421 ttaaaattaa aagcaggtac aaatgattta aacattaact tagttaaaag ttttttcaat
     3481 aagtcattta cctgctttta gtgtaagaaa gaatattgaa tctaaagtgt ttttgaaagt
     3541 gcaatatatt cccttaaaac agaacaagat ttattaaatt cgttttgctc atattcagtc
     3601 atattgattt caataatttc ttcaatacca tcttttccta taacacatgg aacacctgca
     3661 aatacatttc tttcgttata ttgaccttct agtaatgtag aaactggaag aacttttttc
     3721 tcattgtgta gtatagcttt tacaatttct actaaagcag tacctatacc aaattctgta
     3781 caatctttac catttattat acttattcct gtttttttat ttttttcaac tattgatggt
     3841 aagtctaaat tgctataagt acttgggttg tcttttatca tgtctaagat tggtttacca
     3901 ccaattgaaa catgagacca aggaaccatt tgagaatctc catgttcacc catagaataa
     3961 gcttgaattg attgttgagc gattccagtt tcttcagata aaatccttct aagtcttgtt
     4021 gaatctaaag ctgttccagt tccaatgact ttgtttttag gaaagccaga tttttcccaa
     4081 atataatttg taactacatc aacaggatta gatatgacta caaatatacc atcaaagcca
     4141 gaatcaacta tgggttttac tatagatttt atcattccaa tagttggtct tagtaaatct
     4201 aatctagttg tgttttgtct acgtaaaggc ccttctgaag agtctgcaac acttatcact
     4261 actatgtcag aatctttaca gtcagaaaaa gttccttttt ctatatgtac tttatgtggc
     4321 agatatgaaa ctgcatcagc taaatctaaa gcttgagctt ttgatttaga ttcatctata
     4381 tcaatcataa agagttcatc acaaactcct tgagttatta aactaaatcc acaatgagaa
     4441 ccaacatgcc ctgaacctac aatagatatt tttcttggct ttattgccat tttaaatcac
     4501 tccccctaaa ataacgatac attgaaaatt atagatgtta ttaaaagctg tttttggata
     4561 ttttaatatt ctattatttc agaaaattta tttaatatga ttttatacta aaatttttaa
     4621 aaaagcaatg ttaatatact ctctattagt gaatattaaa gtattatatg tatattaata
     4681 attattaaaa tatgtaatgt cactgatagt tagaatattt aagtgctaaa agatgtgtat
     4741 aaataataat gatgtcagtt tataatgata ttaaattgag atatactgtt tctctaaatt
     4801 aaaaaataaa ggagtaaatg gttatgaatt atcatacaaa agaagaattg gtggaagcac
     4861 tgagagtagt atcttcaagt attattaatt gtggaaaagg acagaagaaa ttttctgagg
     4921 agacatctca tcatacacgt tttaagaata ttatagaagt aatgtatatt tcaaaatcat
     4981 taataatgga tgaaattagt aaaagagatt gaagcttatt ttgcaattta acatgtttta
     5041 atatacattt tattatataa gaaaataagt aaacatacat gttataaaat attgaaataa
     5101 tatacaatta taaatttgtt aacattaata tctatatgtt aaaatatagt agaagatgtt
     5161 agtaaataat aggatgagtt ctattttaat acaattaaat taagcttagt ttgaaatttg
     5221 tatctaaaaa gtaaagtaat ctagaattaa gaaaatggag atagaattat aatggaaaaa
     5281 ttatattata caaatcagta tataagagat tttacagcag aaataattga aataaaagaa
     5341 gtagaaaata agtatcatgt tttattagat aagacagctt tttttcctgg tggaggaggt
     5401 cagtttggag acctgggaaa aatagagaat gatgatgtaa taaatgtgta tgaagatgga
     5461 aaaaaaatat accatgtatt agataaaaaa cctataaaga tacataaggt aaagtgtagt
     5521 attgattggg atagaagaga agatggaatg catcaacatt ttggacaaca tgtattgtct
     5581 ggatgttttt ttaaaacttt taatgcaaat acgacaggtt ttcatttggg aaatgagtat
     5641 agtacagtag atatagaagg taatttagaa gaggataaaa ttagagagat agagttgttt
     5701 gccaatgaaa ttattcgtca aaatatacaa gtagagacat tacttccaac gaaaaaagaa
     5761 ctaaaaaaga tttggttaag acgtgatttg ccaaatactg atgaagagat aagagtaata
     5821 aaaataggtg atttagatac gaatgcatgt tgtggagtgc atccaaaatc aactggtgaa
     5881 ttgagaatga taaaaataaa gaaatgggaa aaacataagt caagtacaag aatagagttt
     5941 ctagcaggta aaagggcagt ggatgaagta ttgaagaggg atatatattt gactaaaata
     6001 tgtagatatt taagctgtag tgaggaagat gctataaatg gtattgtaaa tctaaatagt
     6061 aaagtggaag aggctttaat taaaaaaaga aggcttgaag aagtagtatc tacatatcag
     6121 gtcaaagaaa tgattgaaaa agcaaataag gttggcaata tttcggtcat taaaaaaatt
     6181 tatgatgatg aagatttgaa atatgtaaat aagatagcaa ataaaattgc agaatatgaa
     6241 aatagtattg cattattagc tgttaaattt aatgataaaa taaatttagt ttttgcatgt
     6301 tctaaaaatt taaaagatat taatatggga gttttattaa aggatgcaat aagtcttata
     6361 gatggcaagg gtggtggaag taaagtatta gctcaaggag gaggtaagaa taatggaaat
     6421 ttagaggcta cacttgatta tgcatttatg aagatagaaa aaactctata aatatattat
     6481 ataaaaaacc ttagtagata aaatagatat ggaggaataa gtatggagca acaaaaggac
     6541 tacatagagt tatatgaaaa tgaagaacta atagagataa gagaagcacg tatggatgat
     6601 ttggatacaa tagcaaaatt taattataat ttggctaaag aaactgaagg aaaagaactt
     6661 gatatggatg ttttaactaa aggtgtaaaa gcattgttat tagatgagag aaaaggaaaa
     6721 tatcatgtat atacagtatt tgataaagtt gttgcacaga ttatgtatac atatgagtgg
     6781 agtgattgga gaaatggaaa tttcctttgg attcagagtg tatatgtaga taaggaatat
     6841 agaagaaaag gtatctttaa ttatttattt aattatataa aaaatatatg tgataaagat
     6901 gaaaatatag ttggaatgag attatatgta gaaaaagaaa acataaatgc aaaagcaaca
     6961 tatgagtctt taaatatgta tgagtgtgat tataatatgt atgaatacga agtagtacat
     7021 tcgtaatata aatttgtaat actgttatac ttatgttata aagtattgat tatattgacg
     7081 attatatgaa ataaactgga tattataatt agaattttta gggggtataa aaatgggcgt
     7141 tttaaaagga atgttttatg tatttttatt tttagattta gtgtcaatat tctgtttctt
     7201 tttcaataaa ggaaaaatag catctaataa aattgtgttt aatgcaatag gagtacttac
     7261 atttgtactt tgttttatgc tttttagtta ttatcccaat aataatctta ttggaaaatt
     7321 tattgcttct ctatttttta tatttggagt tgcaggagtt atgttgaaag aaaaaaattt
     7381 tttatatgct agacttcttt taactgtagt tatagttttt tctacattaa gattgttcgt
     7441 tattcaataa aatgtatttg tatgaaaatt tattaaagtc tacacattta agtgtaggct
     7501 tttttgattt tttgtttgaa aattaaggaa attttaagga aattttaaaa tcgtcttaaa
     7561 tatttattga tatacttaaa atattaatag cgaaaggaga cttatcagtg atagaaagta
     7621 aaaagtcaga aaaattgtta ctgtcaatta tatacataat atttttggta tatattttaa
     7681 tgattataag aataatttta tttagagatg taccaattta cgctattttc aagggaacgt
     7741 ttaggaatgt aaatttaatt ccattttata caatatatca atttatagta gatagtaatc
     7801 ttgactttat gaaagctact gtaaatatta tagaaaatat aggtatattt attcctatgg
     7861 gaattttttt acctatagta tgtaaaaatc taaataaaaa aactataatt atagtaatta
     7921 tacttgttag cctagcattt gaattaacac aatatatttt tgctcttgga agtagtgata
     7981 tagatgatgt tattttaaat tcattaggtg gcataattgg aattaatatt tacataaaca
     8041 tgaataaatt atttcccagt gatattaaca gatttaaggc tataataggt actagtttag
     8101 ttttaggagt tataggatta ggagttattt ctaaaaatta tcataactta ctaactttta
     8161 aatttagacc tgatagaaaa atatcaaaaa tattaattga agaaaatagg gaaataatta
     8221 aagatataaa taaagataca gtagatatag ttgggacatt tgagagcttt aaaaaaggaa
     8281 taataactat taaagcaggt tctaacaaca aagtaaagag accagagaat ttaattgatt
     8341 ctgatggaaa tataagaatt tatttaaatg aaaatacaaa attagtatct tatataatta
     8401 ccaaagaatc aaaaatggat atagttaaat atgaggaatt tgatgtgaag aatttagatt
     8461 tattaaggag atatgatact attaatgttt ggattgataa agaaaatcag ccaaaggata
     8521 aacatggtat tatggctagt aaattattaa ttggattgta tgaataaaat attaaacaag
     8581 aataaaagaa taacaaatat aaaaaacgaa aaaactattt ctataattat ttttacgttg
     8641 tgcataaaat aagaacatta gtgaaggagt agagataaat tatggagata ataaaatata
     8701 ttttgtactt ttttatatat tcatttttag gatggacagt agaaagtata ggatgttcta
     8761 tagcaagcaa aagaataatc aacagaggtt ttttaaatgg tccaatatgc cctgtttatg
     8821 gttttggagc ggtaattgtg atatcactat tgggaagatt taataatgta gtaatagtat
     8881 ttctattagg aatgatttta actacgatac tagaatattt tacaggattt attttagaaa
     8941 ccttatttca tgctaaatgg tgggattatt ctgacagaaa attcaatata aagggtagag
     9001 tatgtttaaa aaatgcaata tactttggtg taatgtctgt tttaataata agatttatac
     9061 atccatttat aaaatatttt gtaagtataa ttccatatag aatattaatt tcaatggcta
     9121 taattacaac actttggact atacttgatt tgattgttac tattataaca cttaaaaaat
     9181 tagatataaa gttaaactta ttagacgata taattacaga ccttaatgat ataaatgtga
     9241 aattggataa atttgataga ggagaaatac aagctttatt taaaacaata aataacgacg
     9301 aattagaagt tagagaaaaa ataaacaaaa taaatagtaa gttggaccgt atagagtcta
     9361 atattatttt acaaaaaaga gttataaaag cttttccaca tataaaacat aaaaaacaac
     9421 aagagcaact agaacatttt aaaaaaatta ttaatgagaa aaggtaatta tacaatttaa
     9481 tgaagacgaa tagaataatg gtatttataa gatgattttc agaggactct ataaaaatag
     9541 aatagagtcc tttatttttt gaaaaataat gtttatttga taaaaataaa atatattgtt
     9601 tctgaataac aaatattttg aaaattataa aaacatatat tgacaatttg tgtcaaaaat
     9661 actaacatta agtatataaa gaattttata tgagaatatc tttataaatc gcaataattt
     9721 taaaacataa atttatttaa agaggggatg atttgccaat gagcgagata actagtcaaa
     9781 tgataagtac agaagaaaaa aaatatgttg ctaaaactca aaagatacct tattatccag
     9841 tagcatttaa atcaggtgat ggtgcaatgc tatatgatta tgaaggtaat gaatatgtag
     9901 attttttagc aagtgcaggc tctgcaaatg taggtcatgg taataaggaa atctcacaag
     9961 cagttaaaga acaaatggat gatataacac aatatacact tgcatatttc catagtgatc
    10021 ctcctgtaaa attagctgag aagcttgtgg aaatagcccc tggagataat gataaaaaag
    10081 tactatacag tgcaactggt tctgcttgta tagatgctgc tataaaatta gcaagagggt
    10141 atactggaag aacaaagata atatctatgt gtgaatctta tcatggaagt acttatggag
    10201 ctatatctat atctgcttta agtacaaata tgagaagaaa aatgggtcca ttgttaccag
    10261 aagtttatca cttccattat cctgataaaa atagaacagc taaagaatgt ttagatgaga
    10321 tagaatatgc ttttgcacac tatctaccag cagaagaggt agctgcaata tttatagagc
    10381 caattgcagg agatgcagga ataatagtgc ctccagtaga gtgggtacaa ggtttaagta
    10441 aaatatgtaa agaaaatgga atattacttg taagtgatga aatacaacaa ggtatgggaa
    10501 gaacaggtaa gtggtttggt atagaaaatt ttggtgttga agcagacctt atagttcttg
    10561 gaaaatctgt tggaggtgga ttacctctag gagcagttgt tggaagaaca gaaataatgc
    10621 aaagtcttga tgcaccagca catttattta ctttagctgg aaacacaaca gtatgtgtgg
    10681 ctgctttaaa atctatagag ataattgaaa aagaaaactt acttcaaaag agtatagaaa
    10741 tgggagatta tattaaagca ggatttgaaa aactaaaaga aaaatacgat ataattggag
    10801 aaataagagg cataggatta tctataggag ttgatatagt taaaggaaaa ggttctaatg
    10861 aaaaacatcc agatgctaca gctaagatat gttatagatg tatacaaact ggattaataa
    10921 tgatattctt aggacaatct actttaagag tgcaaccacc tctagtaata actaaggagc
    10981 aagtagataa agcaatgaac atcatagatt ctgcaataga tgattattta aatggtagaa
    11041 ttggtgatga agtatatgaa gtaactcaag gttggtaaaa taaatattaa atgaaaatag
    11101 gagttatctc aattttagaa aattatttct gaaatgagat aactctttta agttacccac
    11161 aaataagaaa attgtttgat tcattaaaga ctatatttcg gatgtcgttt ttgtgagtat
    11221 cagagacagt attacgagaa taattacctt tattcgtact atctgttaat ttagttataa
    11281 ttaagatagc taaaagaata agaattactg tgtataaagc aataacatat ggttttcttt
    11341 tatatttgta tttgttattg aaaaaagaat ggccataatt atttttattt actttagatg
    11401 tatttgtatt ctttttcttg ttacctttct ttttatcatc cttttttcta tttttagggt
    11461 aaggaatgac tttgtgtgta ttatcaagtt tgatattttt atttttttga atattgtttt
    11521 ccaggctagc ctttttttct ccaaattgaa tagttttatt ggtattgttg ttatctttca
    11581 atgttaatct ccctccctta aactttccct ttagataata ttactactaa cctatggaat
    11641 atacaataaa taatatataa gtaataaaat tttataggta taaatctctt tctccacgct
    11701 ctaaggcagt catattgtta gatactatgt ttcttatatc ttctctttct atcttaccta
    11761 tttcttctgc gataagtttt ttacccataa ttttaagttc ttcatctcca taatcgatta
    11821 aaaattcatt taatgtagta agagcatttg gtgtacatac attatggatt tgtcgacttt
    11881 tagctaagct catgaatcta tcgccagttc tacctttacg ataacaagct gtacaataac
    11941 taggtatata tccatcagta atcagttctt taagcacctc aacagggctt ctatggtctc
    12001 caacttcgaa ttgttctgta ttgtcaccat cttcatatgc tttatatcct ccaacacctg
    12061 ttagagaacc tgcactaatt tgtgatacac catattttag taactcattt ctcatttcag
    12121 cagtttctct agtggacatt atgattccag taaaaggaac agctaatcta gttatagcta
    12181 ctattttttt gaacatatcg tcagaaacta agtgaggaaa atcttctaag ctcatacctt
    12241 cagctttttt caatctaggg aaagatatag tatggaaacc tacaccaaat ttttcctcta
    12301 agtgttcgtt gtgcatcata agtcctagaa cttcaaattt agggtcagat aaaccaaata
    12361 aaactcctgc accaacatca tcaacaccag cttccatagc tctatcaaaa gctgttaaat
    12421 ggtaataata gtcatttttt atagattgac catgcatttt tataaatgtt ggtttgtgat
    12481 aagtttcttg gaataatata taagttccta ttcctttttc ttttagtaat ttatactcat
    12541 ctacacttgt agctgctatg ttaacgttta cccttcttat atttccgttt tcattatatg
    12601 ttgaataaat tgcatctaag caatctaaga tgtaatttat atcacaattt ttagggtctt
    12661 caccagcttc tagagcaagt cttttatgac ccattttttc taatatttta acctcttctt
    12721 ttatctcttc catggtaagt ttttttcttt taaatttgtt gcatttacta aaaccgcaat
    12781 aaacacattc atttacacag tagtttgata cataaagagg ggcaaataaa accactctat
    12841 taccatatat ttcatttttt atttgcccag ctatactaaa taatctatct agttgttttt
    12901 tatcttccac ttcaagaagt gtagctatat ctttataact aagtttttcc cttctatcag
    12961 ccttatcaag taccttttca atatcatcag aagttgaatt ttttgcatct tctaataaag
    13021 aattaataag ttcatggttt atgaacattt acaaacgcct ccattcaata ttatcaccgc
    13081 gagaatagtc aacttcaagt cctaatgact tgatgttttc ttctaaactt tggtgatatt
    13141 cacaagcttc ttgaccagta aaggctttgt tatcgtaaag agaatattgt tttctaaatt
    13201 cttgaggaga aaggtttggc ataattacat tgcaaccagc taaaagacct gcatttctac
    13261 cactagggtt tatagatgcc aaggctgttg tagcgggtaa taaaactttt ggaagtagaa
    13321 gtcttgtaat tgaaagcata agtaatgtct tctctaaatc tccatgttta taatccttaa
    13381 aaattgtatc atggtgtgga atgaaaggtc ctattccaac catatgagga tttaactctt
    13441 ttaggtataa taaatcacga acaaggtctt cgttgttctg aaatggtgat tcaaccataa
    13501 atccagcacc tacttgataa ccaatttctt taaggttttt taggcattct tttctagttc
    13561 taagctcaat gtttggcgga tgtaattttt tataatgact gtctgtagca gtttcatgtc
    13621 ttaaaagata tctatctgca ccacataaaa agtatttttt atacgaatca taactctttt
    13681 ctcctagtga tagagttatg gcacaatcct catatttatt ttttatactt gaaacaattt
    13741 cacatatttt atcatcagta aaatatgcat cttcaccacc ttgcaaaacg aatgttctgt
    13801 atcctatttt ataacctata tcacaacatt caagtatttc atcaagtgaa agcctgtatc
    13861 ttatgatatt tttattagaa gattgtattc cacaatagta gcaattattt ttacaatagt
    13921 ttgtaagctc tataagtcct ctcaagtaga ctctatttcc ataatgttta tttctcatgt
    13981 cgctagcttg tttataaaga tagtttctta aattttgttc gaagttatat tcctcattgt
    14041 cgatattttc tattaaatat agtagttcat caaaacttaa tgaattaatg ctgtaaagtt
    14101 tatctataaa gtatttaatc ttatttttag tcatattcaa atatgtaatt attaagtata
    14161 gttaaatttt taataattga aaagttcaag tgatctttcc aaaatacctt ttacatatgc
    14221 tattaagaca ccatagttta caataggtac attgaaagat tttgcctttt ctattctaga
    14281 taacattcca gctctattca tcatacaagc tccacagtga actacaaggg catatttatt
    14341 tatatcttca gtgaaggata ctccagaact aaattcaaaa gtaatgtttt tgccagtttt
    14401 ctttctaatc atattaggaa tttttactgt tccaatatca tcagtttgtc tatgatgggt
    14461 acatccttcg gccatcaaga ttttatcacc atcttttaaa ttttctaaag cataagctcc
    14521 attaatcaat tctttaaggt ctcccttttg tctagcaaac aatatagaaa aagatgtaag
    14581 aggaatatct tttggtgtat ctttatctac ttgtggaaat acttgagagt cagtaataac
    14641 aagttttggt tttttgccta aattagatag agtttctttt aaactatctt cttttgtaac
    14701 tatagaaatt gcaccattat ccaaaatatc tcttataact tgctgttgag gaagtataag
    14761 tctacctttt ggagctgctt tatctattgg aacaactaaa acaactaaat catttggttc
    14821 aattaaatct gataccaatt tgaactcagt gctatcctta ggcaaaactt ttattatttc
    14881 attttttaaa ttttcaattc caattttatc tgttgatgag acagaaacaa ctggacattt
    14941 aactttattt ttagttaagt ttaaaatttc tgattgattc ttaatagtat caattttgtt
    15001 aagaattaga atatgaggga tattcttatc attaaatttt tcaattagtg acaaatcttc
    15061 ttgtgatata ccaatttggc aatccactac tagtaaagct atatctgtct tttctaaaac
    15121 atctagtgat ttacctattc taagttcacc aagttcacca acatcatcaa gaccagcagt
    15181 atctataaga acacaaggtc ctataggaag gatttccatt ggtctaaata ctgggtctgt
    15241 agtagttcca gcaatatctg agactattgc agcactttga tttgttatag catttattat
    15301 gctagattta cctgcatttc ttttaccaaa gagacctata tgtactctta ccgattgtgg
    15361 agtagaattt agactcattt gtactcacca ccttaaactt ctttttttga tatactagtt
    15421 tttacagata catgaggtat gttgcctaat ttaccagtca aactattaat agtatccatt
    15481 tcgccaacaa ctgctataca tacgattgag acaccttctt cttcgcaagg aatgcccatt
    15541 cttcctttaa taataccttt aaaacctgat acaacctcat tgaatttaaa ttgacattct
    15601 tttggctctt ccaaaatagc acttataact gcaacctttt tcataaatat cctcctaact
    15661 cagaaaatat gtcttaaaca aatccaaaat caaaaaactt ttctttgtaa agaaaagttt
    15721 ctacaaaaga aaagttatta attacacaag tataatgtgc tatattaaac tatttcctta
    15781 cagattagat aactcttttc tggtagggtt agcttgtaaa aatttaattt aacaacaagt
    15841 aactgaagaa aatttttata caatttatat aaattataat aaaaattaac taaagaaaat
    15901 tgaagttact tatataatag tagtaaattg aaattaagtc tatagaaaaa ccaatttttg
    15961 tataaaaata aaaattaaag ttaattattt gttaagaatt gactttggta aaatatataa
    16021 ttaattattc tttaagcata taatttataa gtaattttag tgtattttca atagcttcta
    16081 tatgtgttct ttcataatgg tgactattgt ttgttccagg accaacacat gctatttgaa
    16141 catcttctcc ccaacgaata gcttctgaag catctgaacc atagaaagta aatacatcga
    16201 cagcgtagtc taaattattg tcttctgcaa catcgacaag cttgtttctt aaattaaaat
    16261 catataatga taaattatct tttgcaacta tagttacacc atgttcacta gatgtttgac
    16321 ttggtccagt aggtgctata tctattgcta caaattcttt tgttttttca ggtaaacatt
    16381 tagaaacacc atgtccaatt tcttcataat tacttatata aaagttagta gtatgcttag
    16441 gtgttaaatt gttttcttta aaatatctac atatttcaag aaccattgct acagctgatt
    16501 tattatctat atatctagat tttataaaac cagattctgt agcctcaaat ctatggtcta
    16561 ggcatacaaa atccccaaca cttattccta aatctaatac atcttgcttt gtaaatactt
    16621 tttcatcaag tctaataatc attgtttctt catttctttc agtggcagct tttgtttgac
    16681 catatatatg agtagaagca tacttaaata caacacttcc tctgattttt ttaccttttc
    16741 tagttataac agtacagttt tctccctcta tagccgccca acatccacca ccaactttat
    16801 ggtatttaag agtaccatca gatgatattt cttttactat agctccaagt gtatccatat
    16861 gtgcagatat tgttatttga tttgaatcat cttcaccagg aagagtagct ataagtgcac
    16921 ctttttttgt aagaatagtg tcaagaccta aattttcaaa atcttttttg atttctaaaa
    16981 ctgcattttc agtatatcca gctgggcttg gaatgtccaa atattttttc attaaattta
    17041 tagtattagt taaatttaaa ttcatattgt ttcctcctaa ataaatatat ttatacaaat
    17101 tataacataa atacaaatgt tctgaaaact aaaattaaaa gaata
//
LOCUS       DAEQCW010000079        16831 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.079, whole genome shotgun sequence.
ACCESSION   DAEQCW010000079 DAEQCW010000000
VERSION     DAEQCW010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16831)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16831)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16831
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.079"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            427..1830
                     /locus_tag="KRO40_002599"
     CDS             427..1830
                     /locus_tag="KRO40_002599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2093416.1"
                     /translation="MKMLNNFFKKINNPAPVFAQTKMERDNQTDDSLSTKPKTTFRDV
                     AGLDEVKEELFEIVDFMKSPQKYQKMGAKIPKGVLFYGPPGTGKTLLASAVAGETNSS
                     FFNVTGSEFVEKYVGVGAKRVRTLFEKARKEAPSIIFIDEIDAVGAKRHLESNNEKDQ
                     TLNQLLVEMDGFNKDSNVLIIGATNRLDLLDEALLRPGRFDRHIHIGAPNYHTRFEIL
                     KVHTDDKPIDKSVNLELLAKKTHGFNGAHLSNIANEAAIFAVRDDSECITSEHFDKAL
                     ERVIAGLESKNSALVEKEKKIVAYHEAGHALVSDIVGICPIQKISIVPRGQALGYVLQ
                     LPDEDRYIYTKDELIGKIKILLAGKASEELIFNHKSTGAKDDLKKVTEIANQMVCEYG
                     MSNLGFMTIDGNDKTFLCDKVQKEANRIVEICYKETLEMLKDNLEDLHSVSKFLFEKE
                     TMTHEELKDLIGKEAVN"
     gene            complement(2307..3329)
                     /locus_tag="KRO40_002600"
     CDS             complement(2307..3329)
                     /locus_tag="KRO40_002600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH2093417.1"
                     /translation="MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEV
                     RERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGDSLGPFYNRIINLFVEKIQEIGK
                     QCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
                     GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGI
                     HNLKEESANYDYDSGYEAGKRMLALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPED
                     LSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEENPESVVEMLKPELI
                     ERGSTL"
     gene            complement(3364..4962)
                     /locus_tag="KRO40_002601"
     CDS             complement(3364..4962)
                     /locus_tag="KRO40_002601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBH2093418.1"
                     /translation="MISSIDVCIIIGYLLLMLVIGYYSGKDNKNQEDYFLAGRSMPWI
                     PIALSVAATMISANGFIGGPGWAYVDGMYPVMVNITVPLAIFFALSITTPVIYKLKIT
                     SIYEYMGLRLGNYSRGLTIIQFFINSLIQASSMVYIPVLIIQMITGWSLYALVPIVVL
                     VSIIYTLLGGIKAVIWTDSIQMIVVISAVFIVIIVALKGMNLSFFDTLQIAQQSGKLN
                     TFDFSRDISVTNTFWATLIGGTVMWIRYFCFDQSQVQRVLTSKSLKCAKNSFVVSAFV
                     MNLVYYFMLLVGVILFVFYGGRTFETSNEIMITFILNELPVGAIGIIIAGVFAAAMSS
                     IDSILNSMTTVFTKDIYEFYFKKDNKESSLKVTMIITVVIGVVMTGFIIMGFGGSIKS
                     ILDLVGNYISYFAGPATGAFVLAMFTYKANDKGVSIGFIVGLVLGFFISNKYNVSWLW
                     NPAIGATITLIFGYIFSVILKKNHNADDIKKYTAFGMRNHLISQGMDKVDGVSIVPFS
                     LGKQELIVLAFFIIQYIILFLIQF"
     gene            complement(5004..6269)
                     /locus_tag="KRO40_002602"
     CDS             complement(5004..6269)
                     /locus_tag="KRO40_002602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093419.1"
                     /translation="MKTTVEIENDIILGKDYSNLKRGIAFFSIALIYFFYCYNFMVGT
                     FIKPTMIYALADGGFGFSLKQTEEIFAVMSFGTIPGTFIFGVISTKIGKKRTLISVAL
                     LIGLTTFIPMLSPTNIMLWKIARLCTGVVLGGVFGTAMPLVADMFPSKYRGKLAAILT
                     ALFSLAMIFGGKVYGVLGDANWQILMYTAIIPPIVGAILAIFFVPDDLEYTKELVKKG
                     KETGEKISYISMYKGKYLWIGLGTILLSGANFTAYSAFSNNATTYLVTGIGMSAAVAG
                     SIYSLQGIGQLVGYLFWGSIADKFGRKIPFIGMALAAVFVFIYTKLGGDNTTTFYMIS
                     VLLGVAVGYSGAWGAYYTELFPSKYRSLSSGMSFNGGRIISTFAIPAIAGTASGTLGM
                     MTIFYISIAVFVAGAIVWLFLPETLNNKK"
     gene            complement(6413..7825)
                     /locus_tag="KRO40_002603"
     CDS             complement(6413..7825)
                     /locus_tag="KRO40_002603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ester cyclase"
                     /protein_id="HBH2093420.1"
                     /translation="MASTNKNNATSKEEEKEVSTSVLESCTVKEKKAKMNQTNFSNIN
                     ENQTNENKTNTYKGNIDKGNIDKTNTNKSDINKVNIDTVDTDKLNTNTLTEKNKKVIF
                     KGEDNMSSTKIYYGDSLEVTPVGVMDYNDFSKQTKREQEIPGFDSKYRDFVDYIMKIT
                     HNIWEEKGIGVIYDTYHNNVTMHCGSSNLVGIKDVISNTLQTLHAFPDRRLIGQNVIW
                     SNFGADGFLSSHRVLSTATNLGDSNFGPATGRKINFRTVIDCATTNNRIHEEWLVRDN
                     LWIVTQLGLNPQEVAKSMAKASESKVLSLQSTYGICESMDGQFMPTKYQAKDDSVGEM
                     MLEMTSRIYNYKYINEVKKYYHDNAVVHFICDKDLNGYDEIQGMIVSLLASIPNGSYE
                     VERVTCNQREKNEGYDVSVRWRLRGINEGIGFFGQPSGKHIEVMGINHYHILQGKVKE
                     EWITFDGMDVLKQMYMGVEE"
     gene            complement(7863..8870)
                     /locus_tag="KRO40_002604"
     CDS             complement(7863..8870)
                     /locus_tag="KRO40_002604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBH2093421.1"
                     /translation="MGKYQYSKKVVRNYFEALENATGDEVENVLKQHMKSDYNWKGVY
                     PFREQEGTENVADVFWKPLKKSLSNMQRRQDIFIAGTNEIDNSEWVMSMGHFMGLFDN
                     DWLGIKHTRKMISLRYAEFNCVQDGKIAKTGLFVDIIGFMIQAGVNPLPPQTGSYFVY
                     PGPIDHNGLLFEDADEVEGVKTLALVNKMVDDLSELNESGAMGCPPEILEKSWAKDMI
                     WYGPGGIGASYTIPRYQEQHQLPFRNNLKGKTFNGHVCRFAEGNFACFFGWPNLTNVP
                     CGGFLGLPGGEVKADMQVVDVYYRKGDKLQENWVLIDIPYWLKQQGLDILERTKSIFN
                     A"
     gene            complement(9067..10389)
                     /locus_tag="KRO40_002605"
     CDS             complement(9067..10389)
                     /locus_tag="KRO40_002605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093422.1"
                     /translation="MKILYVGPGMVIDKILAVSKKNFPNIEADFLRYDRYIEVPDLLE
                     KYRGRVDAVLFTGKSPFKFFEKRQKDFVLSDYIPRHETTLYRVLLEITYLLKLDISRL
                     SIDTYDKAMMKRLYKEIGVEFKDEHMFFAEQKYLEEDYIKFVLEFHKYNYQNNDVCCC
                     ITGLEEAYHIMKKDNIPVVLALPSEDVMVQSIKNIQMRYIAKKNNENQIVVLAIKLNM
                     PSEYSLMKEDEYAYLSQRIKILDKLYHFNSRIDGVLVEQSRSEFMIFTTKKILELETK
                     KYRDIYLLDMIREVSVINTYIGIGYGKTANEAKFNAYESIKMAQSQKNDAAYVVFENG
                     EIMGPLKPNPTVKEKNSFDERFYQIATETGLSANTVYKVFNKIINSGKTEFTSKELAT
                     ICGVSIRTMDRIILRLCDSGYCEVVSEQLMSKYGRPSRILRFKPFLLF"
     gene            complement(10747..12387)
                     /locus_tag="KRO40_002606"
     CDS             complement(10747..12387)
                     /locus_tag="KRO40_002606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacylase"
                     /protein_id="HBH2093423.1"
                     /translation="MFDVKIVNGIIVDGTGNSRYKSDVGIVGDKIMAIGDLSQKEAKE
                     TIDATGKFVSPGFIDFHTHSDLSLVYDKYTRSRIHTGVTTDVIANCGIGVAPIREEKK
                     QELIDYLGTRIIGTIPTKLELHWNTMQEYFDYLTENSPAVNVVAYVAQGPVRINEMGF
                     SKEPATLEQLKNMKLEVRKAMEAGCVALSSGLVYLPGAYTKKEEMAELCKELIPYNGY
                     YISHIRDEGDEEMEALDEAIYIAKTAGVPLHVSHLKVMGHKNFGTIDEVFKKLDEAEA
                     DGLEVTFDCYPYTAGMTSLGALLPPWAFEGGVENMVKRLEVQENRDRIIKELEEGIPG
                     WQCFYQLAGGWNGVVLASVMTEANKYVEGKTLMEVAKINGENPFDTFFRLLIEEKSKI
                     QVVVHTQGQEDTDKVVCHPKSCIGSDSMDLSTEGLLSLGKPHPRAFGTFGRIFSYYVR
                     EKGMLTFEEAVKKITYLSAKRLGIYKERGLLKENYFADIVVFDPDTIEDKATYSNPKQ
                     YTVGVEYVLVNGKIALAGGKQTDVCAGRVIKNPLSIAK"
     gene            complement(12492..13148)
                     /locus_tag="KRO40_002607"
     CDS             complement(12492..13148)
                     /locus_tag="KRO40_002607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093424.1"
                     /translation="MYDKKMIKIGRISIGLAIIANFIPAIYVGIRFGQMPMLSVIFQI
                     WGLVAATYGVSWIVQPIAYYPTLGAPGSYIGWLAGSVGDIRMPAASMAQKIAGVEAGT
                     HEGEVVGTIGTCCSIFVSASMITIFTIVGYKVIPLLPEFVTNSFNYILPALFGAIYVD
                     IARKDIRAGGCTIAVALAIMYFGEKIGIPGGLLTLFIVLGGILITRVFFVIDNNKTKE
                     "
     gene            complement(13174..13875)
                     /locus_tag="KRO40_002608"
     CDS             complement(13174..13875)
                     /locus_tag="KRO40_002608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5058 family protein"
                     /protein_id="HBH2093425.1"
                     /translation="MKFQEMINSPGLWIVSSFLVIISVVQAIVFMKEALKEASNLGIE
                     RKGIKAAIRSASVTAIGPSLSPVITLLSLVAVIGAPTTWMRLCDVGAARTELGVISLT
                     SNLSGVEVGSAAFGAEAFSYALWGMALNNLGWLFVVFILGHRMRGIVEKMNMKYNPTW
                     VKKLLAGATVGLFAYLLSNQIKTFEIPKLTPAIISAIVMLVLTTLFKKNQRLQELSLG
                     IAMLIGMFGTQIILL"
     gene            14683..15162
                     /locus_tag="KRO40_002609"
     CDS             14683..15162
                     /locus_tag="KRO40_002609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2093426.1"
                     /translation="MDKTTFTNNILESEQTLYRVSKSILGNDQDCEDAVNNAILKAYE
                     KLDSLKEEQYFKTWLIRIVINECNSLRRKRLKSLSFEDVFKNKKIDEKDDYSDLYTAI
                     QSLPKKIKIPIVLYYIEGYSVDEVKEILDIPQGTVKSRLSRGRRLLKTKLENTEVII"
     gene            15159..15938
                     /locus_tag="KRO40_002610"
     CDS             15159..15938
                     /locus_tag="KRO40_002610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093427.1"
                     /translation="MNKNILNNSFPEVPESFHNSLSKTLNSLPEREENYKMINNKTHK
                     LPFRKGLVATLAITLILSTTALAVGHIYSLVGKSSTKATYTSIPTTEQVKKDFNFTPN
                     IVSEFSNGYKFKGAYTVNKKAFDKENNVLGKSKALSFEYKNGNDEISLDTANNVLGKS
                     SDNLKVVDTYKDINISYEAFAQKFVPEGYKMTEQDKIDEKSGKYTFSVGPNNESDKVE
                     VNKFKFLTWKQDEVYYSFTVQDSNLSMNDLVKMAHEVIDAK"
     gene            complement(16188..16688)
                     /locus_tag="KRO40_002611"
     CDS             complement(16188..16688)
                     /locus_tag="KRO40_002611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093428.1"
                     /translation="MIEGIKFIKAEEKYIYSYWQTFDKIAKERKYLAMDEAFPFEETV
                     EFIKNIINKNLPQLFIIDLESDNCIGWCDVLPKTEKVGYLGMGILKEYREKGIGSNLL
                     KQIIDLSKEYGYEKIELDVFKSNSRAIHVYKSLGFVEVNTISSGFTWNDRPVKEEVIQ
                     MELTLI"
BASE COUNT         5864 a         3021 c         1994 g         5952 t
ORIGIN      
        1 attctaatat gctactatac tacacaacaa atcctataat tatattctaa tatactacct
       61 actactttgc gctacaacaa tttctctatt tatatgattt gtaaaatata gtacaacatt
      121 ttttatcatt ttcatttcaa ctaaatttgt aatattttat tcaatactta ataaatactt
      181 aatcaataca tgctttataa tactttactc aatatataat caatacataa tttataattt
      241 gtaatacttt attcaataca taagtagaaa tctctatata cataaattca ttttttcata
      301 catcttacaa atttattttt atttagataa catgtatatt ttttccatga aaaataaata
      361 ataaaaaata gtaaatatgg aaaatataaa attgattaac aataattaat tacctgaggt
      421 gtgaatatga aaatgctaaa caactttttt aagaaaatca acaatccagc tcctgtcttt
      481 gcacagacaa aaatggaaag agataatcaa acagatgatt cactttctac aaaaccaaag
      541 actacattta gagacgttgc tggattagac gaagtaaaag aagaactatt tgaaatagtc
      601 gattttatga agtcaccaca aaaatatcaa aaaatgggtg caaaaatacc taaaggagta
      661 ttattttatg gtcctccagg aacaggtaaa accctacttg catctgctgt agctggtgaa
      721 acaaactcat catttttcaa tgttactggt tcagagttcg ttgaaaaata tgtaggtgtg
      781 ggagcaaaaa gagttagaac tctatttgaa aaagctagaa aagaagctcc aagtataata
      841 tttatagacg aaatagatgc tgtaggagca aagagacatc ttgaaagtaa caacgaaaaa
      901 gaccaaacac taaaccaact tttagttgaa atggatggat ttaataaaga ttccaatgta
      961 ttaataatag gtgctaccaa tagacttgac ttattagatg aagctttact tagaccagga
     1021 agatttgaca gacacattca tataggtgca ccaaactatc acactagatt tgaaattcta
     1081 aaggtacata cagatgacaa acctatagac aaatctgtaa atctagaact tttagctaaa
     1141 aaaactcatg gtttcaatgg ggctcatctt tcaaatatag caaatgaagc agctatattt
     1201 gcagttagag atgacagtga gtgtattaca tcagaacatt ttgacaaggc acttgaaaga
     1261 gttattgcag ggctagaatc taaaaactct gcattggttg aaaaagagaa aaaaatagta
     1321 gcatatcatg aagctggaca tgctcttgta agtgatatag taggaatttg tcctatacaa
     1381 aaaatatcta tagttcctag aggacaagca ttaggttatg ttcttcaatt acctgatgaa
     1441 gatagatata tttatactaa ggatgagttg attggaaaaa taaaaatatt acttgctgga
     1501 aaggcttcag aagaattaat atttaatcat aaatctactg gtgcaaagga cgacttaaag
     1561 aaagtcactg aaatagctaa ccaaatggtt tgtgaatatg gtatgagtaa cttaggattt
     1621 atgactattg atggaaatga taagactttc ttatgtgata aggttcaaaa ggaagcaaat
     1681 cgtatagttg aaatttgtta taaagagact ttagagatgt taaaggataa tcttgaagat
     1741 ttacattctg tttctaaatt cttatttgaa aaagaaacta tgactcatga agagttaaaa
     1801 gatttgatag gaaaagaagc tgtaaactaa tatagtttta aaaatttgag gctgtctcaa
     1861 aatagagata agcctctttt tattgttaaa gttataaaaa tacatttgat tttatacaaa
     1921 aaagtgcctc ataaactaaa aatttcattt tgagacactt acatatttta attacatatt
     1981 ttaattttgt ctatttacag aatattatat ctacataaaa ctaaactgct gtaaacttaa
     2041 ctacctccag taatgtttga agtggtataa aagctagtag cctagtttct acacttataa
     2101 tttatatttt acataactaa atttagtaga tttttatact cacaatttag aacgattgaa
     2161 aacttaaaaa tttcttatca gatatctaca acttaattag gtatctatca cttgattaaa
     2221 tatctatcac ttaattaggt atctatcact tgattaaata tctgccattt aattaaatat
     2281 ctaccactta attaaatatc taccacttaa agtgtagaac ctctttcaat caattcaggt
     2341 tttaacattt caacgactga ctctggattt tcttcattta ataaggactt aagtatgtta
     2401 attgtttttt caatcaacaa atctagtggc tgtctaatcg tcgttaaatt ataactcttc
     2461 catgaagcca tttgaatatc atcatatcct atcactgata aatcctctgg caccctcaac
     2521 ttgtactcaa accttgcagc atccattaca ccaatagcta tcaagtcact tgtgcaaaaa
     2581 attgctgttg gaggatttga taatgctaac attctcttac ctgcttcata tccagaatca
     2641 taatcatagt ttgcagattc ttctttaagg ttatgaatcc cactttgtct taacttagag
     2701 taaaatccaa ttttcttttc catttcttca cttgtttctc tcgtaaattg aatatatcct
     2761 atattcttat gacctttctt aagcagatat tcagcagcca ttcccccacc ttcaattggg
     2821 tctacataga ctgtacttat ttttatacca ggtataaaac gattaaaaag aatcacagga
     2881 atattgtttt cttcacaagt ctcagccatc accttattca tggccgaagc tgtaataatc
     2941 acagcttcta cttgaaactg aattactttt gaaattatac tatctatact ttgttgtcta
     3001 ggaactttaa aaacgagaca ctgtttacct atctcttgaa ttttttctac aaataaattg
     3061 ataattctat tgtaaaatgg acctagacta tcaccaacta tcaatcctat aacattagtt
     3121 tttccactaa tcattccccg tgctaccaaa ttaggaacat atcctatttc atttgctaca
     3181 cgaaaaattc tttctcttac ttcaggtttt acgccctttc catttgcact accaaatgct
     3241 cttgaaacag atgattgaga tactcctgcc aatcttgcaa catcttttga ggtagccgat
     3301 ttattataat gaactttctt ttgattcatt tagtatttct ccttaaatat ctagtatttc
     3361 ttcttaaaat tgtatcaaaa ataatataat atattggata ataaaaaaag ctaatacaat
     3421 taattcttgt ttacctaaag aaaatggcac tatagatact ccatctactt tatccattcc
     3481 ttgagaaata aggtgatttc tcataccaaa tgcagtgtat tttttaatat catctgcatt
     3541 atgatttttc tttaaaatga cactaaaaat atatccaaat atcaatgtta ttgtagcacc
     3601 tattgctgga ttccacaacc aactcacatt atatttatta gaaataaaaa atcctaaaac
     3661 taaccctaca ataaaaccaa tagatactcc tttatcatta gctttatatg taaacattgc
     3721 tagtacaaat gcacctgtag ctggtccagc aaagtatgag atatagttac caacaaggtc
     3781 aagaattgat ttgatgcttc ctccaaatcc cataataata aaacctgtca taacaactcc
     3841 tataactaca gttataatca ttgtaacttt taatgatgat tctttgttat cttttttgaa
     3901 ataaaactca taaatatcct tcgtaaaaac agttgtcata ctgtttaata tagagtcgat
     3961 actagacatt gctgctgcaa acacacctgc aataataatt ccaatggctc ctactggaag
     4021 ttcatttaaa ataaaagtaa tcattatttc atttgaagtt tcaaatgtcc ttcccccata
     4081 aaaaacaaat aaaattactc ctaccaatag cataaagtag taaactaaat tcataacaaa
     4141 tgcactaact acaaaagaat tttttgcaca ttttaaagat ttagatgtta aaactctttg
     4201 tacttgagat tggtcaaaac aaaagtatct tatccacatt acagttccac caattaaagt
     4261 agcccaaaaa gtatttgtca ctgaaatatc cctactgaaa tcaaatgtat ttaattttcc
     4321 actctgttgt gcaatttgta atgtatcaaa gaaacttaga ttcattcctt ttaaggctac
     4381 aataattact ataaatacag cacttattac tactatcatt tgaatactat cagtccatat
     4441 aactgcctta atcccaccta atagagtgta tataattgat acaagtacaa ctattgggac
     4501 taaagcataa agtgaccagc cagtaatcat ttgaataata agcactggaa tatataccat
     4561 agaactagct tgaatcaatg aattaataaa aaattgaata atagttaatc ctcttgaata
     4621 atttcctaaa cgaagtccca tatattcata tatagaggtt atttttaatt tatagataac
     4681 tggggtggta atgctcagtg caaaaaatat tgctaaaggt actgtaatat taaccattac
     4741 tggatacatt ccatctacat atgcccatcc aggaccacct ataaagccat ttgcactaat
     4801 catagtagct gcaactgata aagcaattgg aatccatggc attgacctac ctgccaagaa
     4861 ataatcttct tgatttttat tatcttttcc tgaataataa ccaataacta acattaatag
     4921 caaatatcct attataatac atacatcaat tgatgaaatc ataagccacc cctttctaag
     4981 taacaaaata aattcctagt attttatttt ttattattta acgtctccgg taagaataac
     5041 catacaatag cacctgctac aaagactgcg attgatatgt aaaagatagt catcatacct
     5101 aaagtaccag aagctgtacc agctatagca ggtattgcaa acgtagatat aatccttcct
     5161 ccattaaatg acataccaga tgacaacgaa cgatatttac ttgggaacaa ctctgtgtag
     5221 tatgctcccc atgctccaga atatccaaca gcaacaccta gtaatactga tatcatatag
     5281 aatgttgttg tattatctcc acctaatttt gtatatataa aaacaaatac tgctgctaat
     5341 gccataccta taaaaggtat ttttcttcca aatttatctg caattgaacc ccagaataaa
     5401 tatcctacta attgaccaat tccttgtaaa ctatatatag acccagccac tgctgctgac
     5461 attcctattc ctgtcactag gtatgtagtt gcattatttg aaaatgctga atatgctgta
     5521 aaatttgcac ctgataaaag aatcgttccc aatccaatcc ataagtattt tcccttatac
     5581 atacttatat agctaatctt ttcaccagtt tcttttccct ttttaactaa ttcctttgta
     5641 tactccaaat catctggcac aaagaagatt gctaagatag ctccaactat aggtggtata
     5701 atcgcagtat acatcaatat ttgccaattt gcatcaccta aaacgccata tactttccca
     5761 ccaaaaatca ttgctaatga aaataaagca gttaatatag cagctaactt accacgatat
     5821 ttacttggaa acatatctgc aactaaaggc atagctgttc caaatacgcc tcccaacact
     5881 actcctgtac acaaacgtgc tattttccat aacataatat tggtaggaga taacattggt
     5941 ataaatgttg tcaatccaat cagtaaagca acgctaatta aagtcctctt cttcccaatt
     6001 tttgtagaaa tcaccccaaa aataaatgta cctggaattg taccaaaaga cataactgca
     6061 aatatttctt ctgtttgttt taatgaaaaa ccaaatcccc catctgctaa agcataaatc
     6121 attgttggtt taataaaagt acccaccata aaattgtagc aataaaaaaa gtatattaaa
     6181 gcaattgaaa aaaatgcaat tcctcttttt aggtttgaat agtcttttcc taatatgata
     6241 tcattttcta tttcaaccgt tgttttcata tttttataat tccccctttt aaatttagtc
     6301 ataattttgc taaaagttta aacatctatt tttcatatac attccccact taaattttat
     6361 aaagcaatac ttccctatat acatttcaaa actatttata ctctaaacag ctttattctt
     6421 ctactcccat atacatttgt tttaatacat ccataccatc aaaagttatc cactcctcct
     6481 ttactttacc ttgtagtata tgataatgat tgattcccat tacttctata tgctttccag
     6541 aaggctgtcc aaaaaatcct ataccttcat ttattccacg taatctccat cttacagata
     6601 catcataacc ttcatttttt tctctttgat tacaagttac tctttccact tcataacttc
     6661 catttggaat tgatgcaagt aaacttacaa tcattccttg aatctcatca tagccattta
     6721 aatctttatc acatataaaa tgtactactg cattatcatg atagtatttt ttaacttcat
     6781 ttatatattt ataattataa atacggcttg tcatttcaag catcatttcg ccaacagaat
     6841 catcttttgc ttgatactta gttggcataa attgaccatc catagattca cagataccat
     6901 aagttgattg taaactaagc actttagatt cacttgcctt tgccatactc tttgctactt
     6961 cctgagggtt taatcctaat tgagtaacaa tccataaatt atctctaacc aaccattctt
     7021 cgtggattct attgttagtt gtggcacaat caattacagt tctaaagttt atttttctac
     7081 ctgttgctgg tccaaaatta ctatcaccta agttagttgc tgtagacaaa acacggtgag
     7141 aagataaaaa accatcagca ccaaagttag accatattac attttgacca attaatcttc
     7201 tatcaggaaa cgcatgtaat gtttgaagag tattggaaat aacatcttta ataccaacta
     7261 aatttgaaga gccacaatgc attgtaacat tattgtgata tgtatcataa ataacaccta
     7321 tacctttttc ttcccagata ttatgtgtaa tcttcataat ataatctaca aaatctctat
     7381 acttagaatc aaatccaggt atttcctgtt ccctttttgt ctgttttgaa aaatcattgt
     7441 aatccattac tccaacaggc gttacttcta atgaatctcc atagtaaatt tttgtagatg
     7501 acatattatc ttccccctta aatataactt ttttattttt ttcagtaaga gtatttgtat
     7561 ttaatttatc tgtatccact gtatctatgt taactttatt tatgtcggat ttatttgtgt
     7621 ttgttttatc tatatttcct ttatctatat ttcctttata tgtgttcgtt ttattctcat
     7681 ttgtttgatt ttcatttata ttactaaaat tagtttgatt cattttagct tttttttctt
     7741 taaccgtaca tgattcaagc acacttgtag aaacttcttt ttcttcctct ttacttgttg
     7801 cattattttt gttggtagat gccactttat atcccccttt gttttagaat acgtatgcat
     7861 aactaagcat taaaaatact tttagttctc tcaagaatat caagcccttg ttgtttcaac
     7921 caataaggaa tatcaattaa cacccagttt tcttgaagtt tatcgccctt acgataataa
     7981 acatcaacaa cttgcatatc tgctttaacc tctccacctg gtaatcctaa aaaacctcca
     8041 catggtacat tagtcagatt aggccatcca aagaaacaag caaaattacc ttctgcaaat
     8101 ctacatacat gcccattgaa agtctttcct tttaaattat ttctaaatgg tagctggtgt
     8161 tgctcttgat atctaggtat agtataagaa gcaccaattc cacctggacc ataccaaatc
     8221 atatctttag cccaagattt ttcaagtatt tctggtgggc atcccatagc accactttca
     8281 tttaattcag ataaatcatc taccatttta tttactaatg ctaaagtttt tactccttca
     8341 acttcatctg catcttcaaa aagtaatcca ttatggtcaa ttggccctgg atatacaaaa
     8401 tatgaacctg tttgtggtgg caatggatta actcctgctt gaatcataaa cccaattata
     8461 tctacaaata atccagtttt agcaatttta ccatcttgaa cacagttaaa ttctgcatat
     8521 cttaaactaa tcattttacg agtatgttta atgccaagcc aatcgttatc aaaaagtccc
     8581 ataaaatgcc ccatactcat tacccattca ctattgtcaa tctcatttgt tcctgcaatg
     8641 aaaatatctt gtcgtctttg catattactc aatgattttt ttaaaggctt ccaaaataca
     8701 tctgctacat tttcagtgcc ttcttgttca cgaaatggat acacaccttt ccagttataa
     8761 tctgatttca tatgttgctt taagacattt tcaacctcat ccccagtagc attttctaat
     8821 gcttcaaaat aatttcttac aacttttttt gaatactgat attttcccat aattatctcc
     8881 tcccagattt atttaagtta taaattaact ttctcatttc atgcatacga tttccttttt
     8941 aatgattttt cagctgtttt aagtttattt tatgaataca tatgcatttt tctaaatatt
     9001 aacatatatc taaaaaattg taaagaaaat gttatcataa aaatttaatt tttgacttat
     9061 atctatttaa aacaacagaa aaggtttaaa acgtaatatt ctactgggtc taccatactt
     9121 gctcataagc tgttcactca ctacctcaca ataaccagaa tcacacaatc taagtataat
     9181 cctgtccata gttctaatac ttacaccaca tatagtagct aattcctttg atgtaaattc
     9241 agtttttcca ctatttatta ttttattgaa tactttatat acagtattag cacttagccc
     9301 tgtctctgta gcaatttgat aaaaacgttc atcaaaacta tttttctctt tgacagtagg
     9361 atttggcttt agtggtccca taatttctcc attttcaaaa actacatatg ctgcatcatt
     9421 tttttgactt tgagccatct taatactctc ataagcgtta aatttagctt catttgctgt
     9481 ttttccataa ccaattccta tataagtgtt tataactgaa acttcacgaa tcatatccaa
     9541 caaataaata tctctgtatt tctttgtttc taactcaagt atttttttag ttgtaaaaat
     9601 cataaattca cttctactct gctctaccaa aacaccatct atacggctat tgaaatggta
     9661 tagtttatca agaatcttaa tcctttgtga aagataagcg tactcatctt ccttcattag
     9721 tgaatattct gaaggcatgt tcagtttaat agcaagaaca acaatctgat tctcattgtt
     9781 tttctttgca atataacgca tctgaatgtt ttttatactt tgcaccatta cgtcctcaga
     9841 aggcaaggct aaaactactg gaatattatc ttttttcatt atatgatagg cctcttcaag
     9901 acctgtaata caacaacata catcattatt ttgataatta tatttatgaa attcaagcac
     9961 aaactttata tagtcctctt ctaaatactt ttgctctgca aaaaacatat gttcatcctt
    10021 aaattcaact ccaatttctt tatacaatct cttcatcata gccttatcat aagtatctat
    10081 actaagtcta ctaatatcta atttaagcaa atatgtaatt tcaagcaaca ctctgtacaa
    10141 tgttgtttca tgtctaggaa tataatcaga caatacaaaa tctttttgtc ttttttcaaa
    10201 aaatttaaat ggcgacttac ctgtaaaaag aactgcatcc actctacctc tatatttttc
    10261 caataaatca ggtacttcaa tatatctatc atatctaaga aaatctgctt caatattagg
    10321 aaaattcttt ttacttactg ctagtatttt atcgattacc atacctggtc ctacataaag
    10381 tattttcatt tcgtctctcc tttcctaatg atactattat ctcttaaaac attttctaaa
    10441 cctaccatga ctaaagccac aggactcctg attcatagaa ttttgaataa tcaattatac
    10501 ctaatataaa aagttacttt aagtttttta attacgacta tctgttgaaa catttttgta
    10561 tttaaatttt tgtatttaaa tcttattcat taatattaat tacattttac aattaatata
    10621 ttgttttttc tacttaaagt taaattcttt agaaaacaca agtagagtaa tctttattaa
    10681 tttaacaaaa atagccttcc ttaatattca aagaaagact atttttataa aagttcttaa
    10741 tgtattctat tttgctatgc taagaggatt tttaattaca cgtccagcac atacatcagt
    10801 ttgctttcct cctgccaatg caattttacc attcaccaac acatattcca ctcccactgt
    10861 atactgttta ggattactat aagtcgcttt atcttctatt gtatctgggt caaataccac
    10921 aatgtcagca aaataatttt ctttaagtag acccctttct ttataaatgc ctaagcgttt
    10981 tgctgaaaga taagttatct ttttaactgc ttcctcaaaa gtcaacatac ctttttctct
    11041 aacatagtaa gagaaaattc gtccaaaagt accaaatgca cgaggatgag gctttccaag
    11101 agaaagtaaa ccttctgtag aaaggtccat actatcagaa cctatacatg actttggatg
    11161 gcaaacaacc ttatctgtat cctcttgacc ttgtgtatga acaactactt gaattttact
    11221 tttttcttca atcaaaagcc taaagaacgt atcaaatgga ttttcaccat tgattttggc
    11281 tacctccatt aaagttttac cctctacata tttatttgct tcagtcatta cagaggctag
    11341 tacaacaccg ttccacccac ctgctaattg gtagaaacat tgccatccag gaatcccttc
    11401 ctccaactct tttataattc tgtctctatt ttcttgtact tctaatcgtt ttaccatatt
    11461 ttctacaccg ccttcaaaag cccaaggagg taaaagtgca cccaaagatg tcattccagc
    11521 tgtatatggg taacaatcaa aagttacttc caaaccatct gcctcagctt catctagctt
    11581 tttaaatacc tcatcaatag ttccaaaatt cttatgaccc ataactttta aatgagaaac
    11641 atgtagagga actcctgcag tcttagctat ataaattgct tcatcaagag cttccatttc
    11701 ttcatcacct tcatctctaa tatgagatat atagtatcca ttgtatggta tcaattcctt
    11761 acataattca gccatttctt ctttctttgt gtatgctcct ggtaaataaa ctaatcctga
    11821 tgaaagagct acacatccag cttccatagc ttttctaact tccaacttca tatttttaag
    11881 ttgctctaaa gtagctggtt cctttgaaaa tcccatttca ttgatacgta caggtccttg
    11941 tgctacataa gctacaacat tgactgctgg agaattttca gttaagtaat caaagtattc
    12001 ttgcattgta ttccaatgaa gctctaattt tgttggaatt gtaccaatta tcctagttcc
    12061 aagataatca attaactctt gcttcttctc ttctcttatc ggagcaactc ctataccaca
    12121 gtttgcaata acatctgttg ttacacctgt atggatacgg cttcttgtgt atttatcata
    12181 cacaagagat aaatcagaat gagtatggaa atctataaaa ccaggtgata caaattttcc
    12241 agttgcgtct atagtctctt tagcctcttt ttgacttaaa tctccaatag ccatgatttt
    12301 gtctcctaca atccctacat cacttttata tcttgaattt cctgtaccat caacgattat
    12361 tccattgaca attttaacat caaacatgct ttttctcctt tcaagactta tttatattca
    12421 tatttcttaa taaacaatcc tattcttttt tctcaacaaa taattctagt ctttctcctt
    12481 aataagcaat cctattcttt tgttttattg ttatcaatta caaagaagac ccttgtgata
    12541 agtatcccac ctaacacaat aaacaatgtt aataatccac ctggtatacc aattttttca
    12601 ccaaagtaca taattgctaa cgctacagca atcgtacatc caccagctcg aatatcctta
    12661 cgtgcaatat caacataaat tgctccaaat aatgctggaa gtatataatt aaatgaatta
    12721 gtaacaaatt caggtaacaa aggaattact ttatagccta caatggtaaa aatggtaatc
    12781 atagaagctg atacaaagat tgaacaacat gtaccaattg ttccaacaac ttcaccctca
    12841 tgagttcctg cttctacacc tgcaattttc tgtgccattg atgctgcagg catacgtata
    12901 tctccaacag aacctgcaag ccaacctata taagaacctg gagctcctag tgtaggataa
    12961 taagctatag gttgaacaat ccaactaacc ccataagtcg cagcgactaa cccccaaatt
    13021 tgaaatataa cagaaagcat tggcatctga ccaaagcgaa tacctacata gatagcggga
    13081 ataaagtttg caataattgc aagacctata gaaattctcc ctatttttat catcttttta
    13141 tcatacataa ttatcacctc ttatccgttt taatcacaat aatataatct gtgtaccaaa
    13201 cataccaatt aacatggcaa tacctaagga taattcttgt aatcgttgat tctttttaaa
    13261 taaagttgtc aatactagca taactatagc tgaaataatt gctggtgtaa gttttggtat
    13321 ttcaaatgtt tttatttgat ttgaaagaag gtaagcaaat aatccaactg tagctcctgc
    13381 aagtagtttt ttaacccaag taggattata cttcatgttc atcttttcaa caattccacg
    13441 cattctatga cccaaaataa atacaacaaa tagccaacct aagttattta aagccatccc
    13501 ccatagtgca tacgaaaaag cttctgctcc aaatgcagca ctacctactt ctaccccaga
    13561 taaattggat gtaagagata ttactccaag ctctgttcta gctgctccga catcacagag
    13621 cctcatccaa gtcgtaggag cgccaatcac agctaccagt gataataatg taataacagg
    13681 agatagagaa ggtccaatgg ctgtaacact agctgagcga attgctgctt taattccttt
    13741 cctttcaata ccaagatttg aagcctcttt tagtgcctct ttcataaata cgattgcttg
    13801 aacaactgaa ataattacta aaaaactaga aacaatccaa agacctgggc tattaatcat
    13861 ttcttgaaac ttcatacttt attcctcctt aaaataaatt tttcagcatt ttattgtgag
    13921 ctttctttct gtaatcttgt tatgttttta tattgtttta atttatttta tctaagatat
    13981 agtatcttta ataggagatt atctgtctta aagtctcact aaaaacatta atacttaaat
    14041 attttattca taattagtaa atatcagaaa attcacatat tattttttta acctgtaatt
    14101 aacttataag gtcttttatt attttgacat ttcaatataa aaattttaat caaaaaactt
    14161 tattatttta aaaaaaatta ttatttttat aatttatatt ttttaagttt atttatgttc
    14221 atctctatct aaaataatga catttctaac tcttaattct catttaagtt tcattgtttt
    14281 ttcttaaaag cctactttta gtcaagatac tgttatcttt actcattatt taaagaactt
    14341 attttaaatc tgtacatgaa gtaaataatc caaaagcatt gttattctaa ctactcaaca
    14401 ttaaatactt actattttct aattactcaa tataaacact tactataaaa ctaaatatat
    14461 aaatggcttc taaagtttaa tatatctaca tggctttata tatgatggga aaatactaga
    14521 aaaaaatata ttatagaata tttgtataga ataggcaaaa ctttcaaact taaatttatc
    14581 aaataatcat aaaaaaagtg aaccatctat agtaaaattt tatctaataa gtgaaaggca
    14641 aaaaagtagc gctacgattt gcatagaagg gaaggaactt agttggataa aactacattt
    14701 acaaacaata tacttgaatc agaacagact ttgtatcgag tatctaagtc tattctagga
    14761 aacgaccaag actgtgaaga tgccgtcaac aatgctattt taaaagcata tgaaaagttg
    14821 gattctctta aggaagaaca atactttaaa acatggctga ttagaatagt cataaatgaa
    14881 tgtaattcat taagacgcaa acgattaaaa tctctatcat ttgaagatgt cttcaaaaac
    14941 aaaaaaattg atgaaaaaga tgactatagc gatttgtata ctgctattca aagtctacct
    15001 aaaaaaatta aaattccaat agtcctttac tatattgaag gttattcagt agatgaagtt
    15061 aaggaaatat tagatatacc tcaaggaact gtaaaaagta gattatcaag aggaagaaga
    15121 ttattaaaaa ctaaattaga aaacacggag gtaatcatat gaataaaaat atattaaata
    15181 attcgtttcc agaagttcca gaaagttttc ataatagttt aagcaaaaca ctaaatagtt
    15241 taccagaaag agaggaaaat tataaaatga ttaataataa aacacacaaa ttaccattta
    15301 gaaaaggctt agttgcaact ttagccatta ctttgatatt gagcacaaca gcccttgcag
    15361 taggacatat atatagtttg gttggaaaat caagtactaa ggctacctat acatctatcc
    15421 caactacaga acaagtaaaa aaagacttta actttacccc taatatagtt tctgaattta
    15481 gtaatggata taaatttaaa ggagcatata ctgtaaataa aaaagcattt gacaaagaaa
    15541 ataatgtttt aggaaaatca aaagcactta gttttgaata taaaaatggc aatgatgaaa
    15601 tatctcttga cacagcaaat aatgtacttg ggaagagttc tgacaatcta aaagttgtag
    15661 atacttacaa agatattaat atttcttatg aagcattcgc acaaaagttt gtaccagaag
    15721 gttataaaat gacagaacag gataaaattg atgaaaaatc aggcaaatac acatttagtg
    15781 tagggccaaa taatgaatca gacaaagttg aagttaataa atttaagttt ttgacatgga
    15841 aacaagatga agtttactat tcttttacag ttcaagactc aaatttatct atgaatgact
    15901 tagttaaaat ggctcatgaa gtaatagatg caaaataaac ataagtaata ataagttgtt
    15961 tatgagttta ttatttatga ctttaatttt tttattagta aacatggttg tatcttccat
    16021 ctttatattt tctttaaatt taatatataa aattttagat atttagctac cttcaaaaga
    16081 accattatta aaaagccctt aaaaatattt cttttatatg gaattttaag ggctttaact
    16141 ttattttata caagtgtata tggaatttta aagactttaa ctttatttta tataagtgta
    16201 agctccattt gaattacttc ttcttttaca ggtctatcat tccatgtaaa accactagat
    16261 attgtattta cctctacaaa ccctaaagat ttataaacat gaatagctct actattactt
    16321 ttaaatacat caagctcaat tttttcatac ccatattctt ttgataaatc aataatttgt
    16381 tttaaaagat tacttccgat acctttttcc ctatactctt taagaatacc catgcctaaa
    16441 taaccaactt tttcagtttt aggtaaaacg tcacaccaac caatacagtt atctgattct
    16501 aaatcaatta taaacagttg tggtaagttt ttatttataa tattttttat aaattcaact
    16561 gtttcttcaa aaggaaaggc ttcatccata gctagatatt tcctctcttt tgctatttta
    16621 tcaaaagttt gccaatacga ataaatatac ttttcttctg cctttataaa ttttatgcct
    16681 tctatcaact taacatttcc cctttttaat ttgtgattgt agttaactta ttttatatga
    16741 ttctagttta taatgctata taaattacta tatattagct taaaatatct ttgtatattt
    16801 ctataaaatt aaaaccaata tatctatctc t
//
LOCUS       DAEQCW010000080        16800 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.080, whole genome shotgun sequence.
ACCESSION   DAEQCW010000080 DAEQCW010000000
VERSION     DAEQCW010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16800)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16800)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16800
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.080"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(16..1047)
                     /locus_tag="KRO40_002612"
     CDS             complement(16..1047)
                     /locus_tag="KRO40_002612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sulfate exporter family transporter"
                     /protein_id="HBH2093429.1"
                     /translation="MLKKKSSLTLKTIREILPGLFVSVLVGYISIFISILIPKVGAAS
                     ISIFLGMFVGNLFLNQKVFQKGYKFSETDLLSYSIVLLGATLSVSTLIDLKVSGILFI
                     ILQMTITIIAALYIGKKLGFEENFRFLMASGNAVCGSSAIGATVPVVNATDKEKGIAV
                     TIVNVTGIFLMFLLPIISQFLYSHELVKTSAMIGGTLQSIGQVVASGAIVGENVKDLA
                     TIFKIVRVIFLVVVVLVFGHMKNQSNREILEEEKDEIKKKKVTIPWYVIGFFITCALF
                     SMNIIPQEVSVLCKEISNKLEIIALAAIGLKVNVKDLVKQGKEVSLYGLFVGTVQVVS
                     AVVLIKIFI"
     gene            1235..2125
                     /locus_tag="KRO40_002613"
     CDS             1235..2125
                     /locus_tag="KRO40_002613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2093430.1"
                     /translation="MFEELKTFVAVVEYKNFTKAGEYLNLSQPSVSKHIKNLENYFKV
                     VLINRSIKQKTIFITESGQILYKRAKEILNLLNITYHDVSQVSDAITGHLKIGASLTI
                     GEYILPNFLALFSKKYPDIDVEVFIKNTSIVSSHVKDYILDIGLIEGTCSSPSFIQEY
                     FFEDKMVLALPYKSHLLKDFSFDKLQNQKWIVREDGSGTRDYLDMFLSVKEIIPKSMM
                     VFGSNYAVKESVRNNLGITIVSNLVTSLPVLNNELSVIELGSSYNRHFSYIFPKDITL
                     SKAATIFIEELKIFSNLNSI"
     gene            complement(2177..3103)
                     /locus_tag="KRO40_002614"
     CDS             complement(2177..3103)
                     /locus_tag="KRO40_002614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketopantoate reductase family protein"
                     /protein_id="HBH2093431.1"
                     /translation="MKNQLNENHKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERK
                     KRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGLKYNNLKENIKELDGLVGKNTVI
                     MSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
                     KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRE
                     LAKSAMREVVAIAQAKNISLTEDDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMF
                     SKNICKLGKKYNIPTPINQTFFYMIKVIESRF"
     gene            complement(3446..4636)
                     /locus_tag="KRO40_002615"
     CDS             complement(3446..4636)
                     /locus_tag="KRO40_002615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009271880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH2093432.1"
                     /translation="MSNVKRKDSKNRNLRNGESQRKDGRYVYKYTDIYGKPQFIYSWK
                     LVPTDKTPAGKRDDISLREKEAQIKKDLNDGIDTVGGKMTVCQLYDKKNSQRKNIKRA
                     TEKGRQYLMNALKNDPLGMRAIDTVKQSDAKEWAIRMSEKGYAYKTIDNYKRSLKASF
                     YMAIQDDCIRKNPFEFKLSDVLEDDTEQKVILTPEQEERLLAFMEKDKIYSKYYDEVV
                     LLLETGLRISEFCGLTTHIDMQNRILNIDHQLLKDSEMGYYIETPKTKNGKRELPLTE
                     RAYQAIQRILKNRGKAQPLIVGGYSNFLFLNREGLPKVAGNYEGMVRGLIKKYNKYHT
                     DKLPNITPHSFRHTYCTNMANRGMNPNTLQYLMGHANITMTLGYYAHGTFQSAKAELE
                     RLAC"
     gene            complement(4715..4918)
                     /locus_tag="KRO40_002616"
     CDS             complement(4715..4918)
                     /locus_tag="KRO40_002616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBH2093433.1"
                     /translation="MNNTDVPIWEKYTLTVEEASKYFRIGEKKLRKLAEENLDAGWVI
                     VNGNRIQIKRKQFEKIIDTLDEI"
     gene            complement(5292..5546)
                     /locus_tag="KRO40_002617"
     CDS             complement(5292..5546)
                     /locus_tag="KRO40_002617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009264382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093434.1"
                     /translation="MKQLFKKPSYYLISSAMDGNEKAIEKLLAFYDPYISKCCLRSLY
                     DEYGNVYIVVDMELKGRIREALIKMILGFDIEDMDLEPEE"
     gene            complement(5550..5969)
                     /locus_tag="KRO40_002618"
     CDS             complement(5550..5969)
                     /locus_tag="KRO40_002618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009269712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2093435.1"
                     /translation="MKPSDFQKTVQCRFESCLKKVVRSVVKDYYKELNRRKNKEISFS
                     ELPDVIVDKMTVWDDYETDYTIFSVCGIDIRVLDDELAEALKKLPERKRNTLLMYYFL
                     EMTESEIANLQKITQSGVFRNRHHALEIMKKILKEEH"
     gene            complement(6261..6635)
                     /locus_tag="KRO40_002619"
     CDS             complement(6261..6635)
                     /locus_tag="KRO40_002619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093436.1"
                     /translation="MELYLNDVYPYAQQISNYIEREIFQQKLKAGQKLLSITNLSKEL
                     NVSKHTIQLSYKILRKKELIVKKGNDFFVTKDNCCIITKMKEETDLQIIKCLHELAEM
                     GYSREQTKSLILRKLETLKFPQ"
     gene            complement(6683..7684)
                     /locus_tag="KRO40_002620"
     CDS             complement(6683..7684)
                     /locus_tag="KRO40_002620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2093437.1"
                     /translation="MSFFTFLEEKITEILFQLFFLALVAFLLIFYGVDTLFVVLLVIL
                     FISIQGLFQWCLYRKKRKASQHIIDLVDGLEETYYIADVLPKPKEFQNEAYYYALKKA
                     CKSMNDEIGKITEEKQDYQEYVESFAHEIKIPIGALSLTFDNTKNYTLKKETDKIFQL
                     VEQMLYYARSENTEKDYFVKQLQLDEVIHNVILKFRHSLMERKVIINIHDIENVVYTD
                     EKWLTFILSQIVQNAIKYFDKQENKLTIYSQDNGTNILLVIEDNGCGIKTSDLSRVFE
                     KGFTGSNRNKANATGMGLYLSKKLSDRLGLKLDITSKETEYTRLTITFPKGTVHNLH"
     gene            complement(7681..8340)
                     /locus_tag="KRO40_002621"
     CDS             complement(7681..8340)
                     /locus_tag="KRO40_002621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009269714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding response regulator"
                     /protein_id="HBH2093438.1"
                     /translation="MRIAIIEDDEITRLELSKLLNTQGYETVLLTNFENLTEELKQYC
                     VELVLLDINLPYENGYEVCRKIKQAMPVPIIFVTSRDTNADELKSIQVGGIDFITKPY
                     DTLILLEKIKRALQLSNPNNFRELVKKDCTLDLHLSILKYQEKSIELTRNEFRILYYF
                     FMNEDKVISKEELLEKLWNDKYYLDENVLLVNMTRLKKKMKEIGIVHLLENIRGKGWK
                     L"
     gene            complement(8399..10378)
                     /locus_tag="KRO40_002622"
     CDS             complement(8399..10378)
                     /locus_tag="KRO40_002622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009269715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093439.1"
                     /translation="MLGKLAVRNTKRSIKDYLIYLITVTIAFSLIFAFNLVASSEEVI
                     ELSTGMDTFKYILAFVNVVIIFVICFLINYTTKFMFEKRSKELGTYMLLGIRKKEIAR
                     LLVIENVLLAICALVLAIPLGFIFSQFVSLVIVNLLGIPEVIFISINFVSIGLLAIYF
                     LAIYVLVLLNLLRRIRKMTVHDFLYFDKQNEKKMFRSNKKRNIIFIVSVILGITAILL
                     WASRWTMENSGKQETLTYLMISMMMLIISIYGVSATCADMLLSVLLKNKKLKYQKDNL
                     FVTRTFASKARTMSFTFGTLSMLILLSLLCLNFSSINKGVYKASIEMTAPFDVHVFEE
                     KQPFKDFKEYVNVVDEDYTINKAIEFDVYKEPKHQMQNYFDVQFYDYDPVMKLSDYNE
                     ILKLKNMDTIELSNDEYFLVTSKDLLYKVENNKDIEKIQLTSGKELKLKGIDTKTYWY
                     QINNTGRFAVIVPDEYVQGLEVSEQHLIIDTIEETDTKLREKIKQDLKHRLVIVNDDG
                     ETVVQYYRLSVRGSAIEEQNTMTAMIASICLYIAFILISAVGTVLAIQSLSDSTKYKY
                     RYQTLKRLGVNDKSLFKTIRKQLLILFGVPVIYSILASFFMLVSVNNVYKIYLESEYS
                     YLIYFVVGLAIFFFIYGIYWIATYIGFKRNINEES"
     gene            complement(10368..11138)
                     /locus_tag="KRO40_002623"
     CDS             complement(10368..11138)
                     /locus_tag="KRO40_002623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093440.1"
                     /translation="MEHILNLEQVKKYYGGNSGNITKAVDGISMYVDKGEFVAIMGAS
                     GSGKTTLLNCISTIDTVTSGHITVNNQDITKIKDKDFADFRRENLGFIFQDFNLLDTL
                     TIEENISLSLVINKQNPADIDKRVHAIADKLGIRDILSKFPYEVSGGQKQRCACARAL
                     INEPKLILADEPTGALDSKSSRLLLETMSDINKKMQATILMVTHDPFSASFCKRILFL
                     KDGKIFNEIFRGEKSRKDFFNEILDILTLLGGEVGNVR"
     gene            complement(11338..11856)
                     /locus_tag="KRO40_002624"
     CDS             complement(11338..11856)
                     /locus_tag="KRO40_002624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018595824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2093441.1"
                     /translation="MNVLDIAKKRYSVRTYEDKPVEKEKLDKILASAHVAPTAANLQP
                     VKLLVVQDKERLKSIAKAGNIYNAPLAIIVCADHSKAWKRPFDNKQTTDIDATILTDH
                     MMLQATELGLGTVWVCFFKPNVIKREFQLPDNLEPVNILVIGYGKETPADPERHFATR
                     IPMEELVSYDYL"
     gene            11982..12305
                     /locus_tag="KRO40_002625"
     CDS             11982..12305
                     /locus_tag="KRO40_002625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007488174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2093442.1"
                     /translation="MENNCCGFSCPVEATIQLIGGKYKAVILWHLMNKTLRYSEIHKL
                     IPKATDKMLAQQLRELEKDGLINRKVYPVVPPKTEYSLTEFGKTLTPILDELCNWGEN
                     YLLQN"
     gene            complement(12363..12593)
                     /locus_tag="KRO40_002626"
     CDS             complement(12363..12593)
                     /locus_tag="KRO40_002626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004612099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093443.1"
                     /translation="MIGLKKRDIKKALKAGANASGVSLADIRADIEATIDEAMNSTDP
                     EVQANFKKYFGNKRPTPEEYIYKITKKTKVKL"
     gene            complement(12696..13598)
                     /locus_tag="KRO40_002627"
     CDS             complement(12696..13598)
                     /locus_tag="KRO40_002627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2093444.1"
                     /translation="MFKKNKKQTENVKEKMVRTVKVGTHKKTVIALWVVLIASVSFGV
                     YKNFTAIDQHTTHEKEIIELRLQDTNGIENFVKNFAKSYYTWSNSKEVIEARTQAISG
                     YLTKELQDLNVDTIRMDIPTSSTVTDVIVWSIEQSGTDTFSATYEVDQQIKDGEQTSN
                     VKATYTVKVHVDADGDMVIVQNPTLAPAIEKSDYEPKTPETDASVDADTVNDAAAFLE
                     TFFKLYPTATEKELAYYVSGNVLEPIGRDYLYSELVNPIFTKDGGNVKVKVSVKFLDN
                     QTKATQVSQYELVLHKDSNWKIVG"
     gene            complement(13614..14621)
                     /locus_tag="KRO40_002628"
     CDS             complement(13614..14621)
                     /locus_tag="KRO40_002628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009243519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HBH2093445.1"
                     /translation="MKLKHIALIGSLFPLLFSLVLFFGVLISADSDDENSNFSSGITG
                     MNLSAEVLKHQPMVEKYAKEYGISEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPNS
                     LDTESSIKQGCKYFASLLSSCKNQGIDDLNVAIQSYNYGGGYVGYVAGKGKKHTYNLA
                     EIFAREKSGGKKVTYTNPIAVAKNGGWRYGYGNMFYVELVNQYLTVPQVSGELAQKVM
                     NEALKYQGWKYVYGGSNPNTSFDCSGLVQWCYGKAGISLPRTAQAQYDATQHLPLSQA
                     KAGDLVFFHSTYNAGTYVTHVAIYVGNNQIYHAGDPIGYADLSSSYWQQHLIGAGRVK
                     Q"
     gene            complement(14618..>16800)
                     /locus_tag="KRO40_002629"
     CDS             complement(14618..>16800)
                     /locus_tag="KRO40_002629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBH2093446.1"
                     /translation="GAFTKKKILHVLKMALFVVALSLILLSLLGTVAHATGLVDDTIN
                     AENLYSKYPLSNYQLDFYVDNSWSWLPWNWLDGIGKSVQYGLYCITNFVWTISLYLSN
                     ATGYVVQEAYKLDFINDMADSIGKSIQTLAGVTQNGFSSTGFYVGFLLLIILVVGLYV
                     AYTGLIKRETSKALHAVINFVVVFVLSASFIAYAPDYIKKINEFSSDISTASLDLGTK
                     IMLPNSDSEGKDSVDLIRDSLFSIQVEQPWLLLQFGNSNAEEIGTDRVEALVSASPED
                     EDGKTREEVVKTEIEDNDNNNLTIPQVVNRLGMVFFLLFFNLGITIFVFLLTGMMLFS
                     QILFIIFAMFLPISFLLSMIPSYESMAKQAIVRVFNTIMTRAGITLIVTVAFSISSMF
                     YNISTDYPFFMVAFLQIVCFAGIYMKLGDLMSMFSLNAGDSQNMGRRIFRRPYLFMRH
                     RARRMERRLAGAVTAGGVAGAVAGSTISNRKPTRNTATKDSRGNTSTSSMGQRAGSKV
                     GAVLDTKNKVKDKANAVKENIKDMPTQTAYAVYSAKEKAKSSVSDFKRGMVQEQLSRQ
                     TGRLERQEQHRQNIADKRMELQKAQEARQAQRKADGSATTGATRPHERPATASTIPKP
                     SAEKMQEVKRPATATTSKASEPVKTTVIKERPLSSGASDRKATQSAQIAHRQNVEKVV
                     SQETRQNYTKDRRTKVQQTQSVQKNQQTTEKTRNLVTKKGQKKK"
BASE COUNT         4956 a         3352 c         2618 g         5874 t
ORIGIN      
        1 aatactattt ttatgctata taaatatttt tattaaaact acagctgata caacttgtac
       61 tgtacctaca aataaaccat ataaagaaac ttctttccct tgtttcacta aatcttttac
      121 attaaccttt aatccaattg ctgctaaagc tattatttct agtttgttac ttatttcttt
      181 gcacaacaca gatacttctt gtggtataat gttcattgaa aaaagtgcac aagttataaa
      241 gaatccaatt acataccatg gtatagtcac ttttttcttt tttatctcat ccttttcttc
      301 ttcaagaatt tccctattag attgattttt catatgtcca aatactaata caacaacaac
      361 tagaaatatt actcttacta tcttaaaaat agtagctaaa tcttttacat tttctccaac
      421 aattgctcca cttgctacaa cctgaccaat tgattgcaaa gttccaccta tcattgctga
      481 agtttttaca agttcatggc tatataaaaa ttgagatatt attggaagta aaaacataag
      541 aaatatacca gtaacattta caatagttac tgcaattccc ttttctttat ctgtcgcatt
      601 aaccactgga actgttgctc ctattgcaga agaaccacat actgcatttc cacttgccat
      661 tagaaatcta aagttttctt caaatcctag ttttttacct atataaagtg cagctattat
      721 tgttattgtc atttgcaata ttataaataa aattcctgaa acttttaagt ctattaaggt
      781 agatacactg agtgttgctc ctaatagtac tattgaatat gataacaaat ctgtctctga
      841 aaatttataa cctttttgaa ataccttttg atttaaaaat aggtttccta caaacatacc
      901 taaaaatata gaaattgatg ctgcccctac cttaggaatt aaaatagaaa taaatatact
      961 aatataacct actaatactg atacaaacag ccctggtaat atttccctta tagtttttaa
     1021 tgtcaaactg ctttttttct ttaacataat atacctacct tataattaat atagttttct
     1081 tcatagcaat agtatataat tgtaataacc ataagtaaaa taaatatata atatcgtaat
     1141 gattaatgtt tttaatggtt attatatata gtataattat ctgtagaaag tatataaaaa
     1201 atgtaaaatt tcattaggta aaggagacaa aaaattgttt gaagaattaa aaacatttgt
     1261 agctgttgtt gaatacaaaa actttactaa agctggggaa tatttaaatc tatcacaacc
     1321 aagtgtaagt aaacacataa aaaatctaga aaattatttt aaagttgttc ttataaacag
     1381 gtccattaaa caaaaaacca tttttataac agaaagtgga caaatcttgt acaaaagagc
     1441 taaagaaata ttaaatcttt taaatattac ttatcatgat gtaagccaag tttcagatgc
     1501 tataactggt cacttaaaga ttggtgcaag tttaactatt ggagagtata ttttaccaaa
     1561 ttttctagca ttattttcta aaaagtatcc tgacatagat gtagaagttt ttataaaaaa
     1621 tacatcaatc gtatcttctc atgttaagga ttatatttta gacattggtc ttattgaagg
     1681 cacttgctct tccccttcat ttattcaaga atattttttt gaagataaga tggttttagc
     1741 acttccatac aagagtcatt tattaaaaga ttttagtttt gataaacttc aaaaccaaaa
     1801 atggatagtc agggaggatg gttctggaac cagagattat ttagatatgt ttttaagtgt
     1861 taaagaaatt attccaaaaa gtatgatggt ttttggaagt aattatgctg tcaaagaatc
     1921 tgttagaaat aatttaggaa ttacaatagt ctctaatcta gtgacaagct tacctgttct
     1981 aaacaatgag ctgtctgtca tagagcttgg aagcagctac aacagacatt tctcatatat
     2041 atttccaaaa gatataactt tatcaaaagc agcaactatt ttcattgaag agttaaaaat
     2101 atttagtaac ttaaatagta tataacatta ataaaattta aaatcaataa ttatcaatat
     2161 ttcttacaaa gaccctttaa aatctacttt caattacttt tatcatataa aagaaagtct
     2221 gatttatagg agtaggtatg ttatattttt ttccaagttt gcagatattc ttagaaaaca
     2281 tatctacttc tgtaagtcta tgagcttcca catcttgaag cattgatgtt cttccttctt
     2341 ttgaatgttc tagtattcta tgtaatgaat gttccacatc atcttctgta agagatatgt
     2401 tttttgcttg tgctatagca acaacttccc tcattgcaga ttttgctaat tctcttaaat
     2461 gctcagaact ctgaaaaact ccataaggtg caccaagtat agctgaagtt tgatttacac
     2521 caatattaac catgtacttc caccacatat ctcgttgaat atcttttgat aaagtatatt
     2581 ctatatttac atcatcaaag acttcggtta ttatattagt ttttctatct tcactattat
     2641 ctttgttacc aaatacaatt atcccattag tagtgtgtat aatattatta ttgattttct
     2701 ttgcatctat attggtaaca tatgaatata ccattttttc aattccaaat ctttctccta
     2761 ttatctcttc gctatcaact ccatttagca gagacattat aactgtattt tttccaacta
     2821 atccatctaa ttcttttata ttttctttta aattattata ttttagacct ataattataa
     2881 aatcagcctc ttgtttatac tcatctttag ttacataatc aaaatcatac ctttttccat
     2941 ttattataaa tccttcttct aaatatcttt tctttctttc attatcacaa agaattttaa
     3001 aatcatattt agagttaaaa aattgttctg caaaagtagc tcctacagca cctactccaa
     3061 aaaatacaac ctttttatga ttttcattta attgattttt catacttacc cctccctaat
     3121 atataatact tttaccttat acttatattg tactgctact atctcttatt ttgtaaatat
     3181 atttttaaca aaaaaaacag ctaaccttca tttataaggc taactgcttt ttatttttaa
     3241 gttatatgtt atattacaaa tttttaaaat aaaaacttac taaatttctg attatctttt
     3301 cataagttgg taaatgccga tatatcccgt attttagagc tttatcggta ttttcttttt
     3361 ggaagatacc ttgcataagc tggcatttac cagcatgaaa atgcaaccaa aagtagtaaa
     3421 tgagtagtaa atataagctc cgatattaac aagccagtct ttccagctct gcttttgcag
     3481 attgaaatgt accgtgtgcg taatagccaa gtgtcatggt tatgttagcg tgtcccatga
     3541 gatattgcag ggtgtttggg ttcattcctc tgtttgccat attcgtacaa taagtatgtc
     3601 ggaatgaatg tggtgtgatg ttcggtaact tgtctgtgtg atacttgtta tacttcttaa
     3661 tcagtcctcg caccatgccc tcatagtttc ctgcaacttt aggtaagccc tcacggttca
     3721 agaataggaa attgctgtaa ccacctacaa tcagcggttg tgcttttcct ctgttcttta
     3781 gtattctttg gattgcttga taagcacgtt ctgtcaatgg aagttcccgt tttccatttt
     3841 tggtctttgg cgtttcaata tagtagccca tttcgctatc tttcaataac tggtggtcta
     3901 tattgagtat tctattctgc atatcaatat gcgtcgtcaa tccgcaaaat tcagaaatac
     3961 gaagtcccgt ttccagcaga agcacaacct catcataata cttgctgtaa atcttgtcct
     4021 tttccataaa ggcaagcagg cgttcttcct gctctggtgt aaggataact ttctgctccg
     4081 tatcatcttc cagaacatca cttagcttaa attcaaacgg gttctttctg atacagtcgt
     4141 cttgtatcgc catgtaaaat gacgctttca aggaacgctt gtagttatca atcgttttat
     4201 aggcatatcc tttttcgctc attctgatag cccattcttt agcgtccgac tgcttaacag
     4261 tatcaatcgc cctcataccc aacgggtcat ttttcagagc gttcataaga tactgtcgtc
     4321 ctttttcagt agccctcttg atgttctttc tttggctgtt cttcttgtca taaagctggc
     4381 agactgtcat tttaccaccg actgtgtcga taccgtcgtt aaggtctttt tttatctgtg
     4441 cttctttttc cctcaacgat atatcatcac gctttccagc aggtgtcttg tctgtcggta
     4501 caagtttcca agaatagata aattgtggct ttccgtatat atcggtatat ttataaacgt
     4561 atcttccgtc ttttcgctgg ctctctccat tacgcaaatt gcgattttta ctgtcttttc
     4621 gtttcacatt agacatagtg taaagctcct ttccgtcatg gaatgagccg tgatacgcta
     4681 tatcttatta taccatatct acggctcaat gacattagat ttcgtccaat gtatctatga
     4741 ttttttcaaa ttgttttcgc ttaatctgaa tacggttgcc gttcacgata acccagccag
     4801 cgtcaagatt ttcttcggct aatttacgca atttcttttc gccaatgcgg aagtatttgg
     4861 acgcttcttc aaccgtcagc gtatattttt cccaaatagg cacatcagta ttgttcataa
     4921 tctatgcacc ccctttactg tgtgtcgttt tttacaagca ggcagacggc tttggaaagc
     4981 tccattagta tctcaactat tcccattctt gtgggcagaa ccgcaccatg cggacgtatc
     5041 attattctgt gaggataggt cgtggcaaaa caacttttcc aacagtcgct ctcggatcac
     5101 tgcgtgggtc gctcgctttc ttttgaaaag gtcgtggcgt acagtccccg tggctcgcca
     5161 tctcacaaac gtatctgtct gctttattca gttgtcaaag agctgtggcg aaagcgtgtt
     5221 gctttcatat aaaagcaggt ggcagagcag gaaagagggg ggatattaaa tcatgctccg
     5281 ctaaaaactg cttattcttc tggttctaag tccatatctt caatatcaaa acctaaaatc
     5341 attttgataa gtgcttctct gatacgtcct tttaattcca tgtctacaac aatataaaca
     5401 ttgccatatt cgtcataaag tgaacgtaaa cagcactttg atatgtacgg gtcataaaat
     5461 gccagcaatt tctcaatcgc tttttcgttt ccgtccatag ctgatgaaat caagtaatag
     5521 gacggctttt taaataactg tttcattttc taatgttcct ccttgagtat ttttttcata
     5581 atttccaaag cgtgatgtcg atttctaaat acaccgcttt gcgtgatttt ctgcaagttg
     5641 gcaatttcac tttctgtcat ttccaaaaag taatacatca acagagtatt gcgttttctt
     5701 tctggaagtt tcttcaatgc ttctgccaat tcatcatcaa ggacacgaat atcaatgcca
     5761 catactgaaa agattgtata atctgtttcg tagtcgtccc aaacagtcat tttatcaaca
     5821 atgacatctg gcaattcgct gaaagatatt tctttatttt tacgacggtt taattccttg
     5881 taataatctt tcacgacact acgaacaact ttctttaaac aactttcaaa acgacattga
     5941 actgttttct ggaagtcaga cggtttcatc aatctcacct cctttccttt atgatttgaa
     6001 aagtgtttat ccctctttcc gcaccatata aggacagcta ggtgtgattt aatgacctct
     6061 tttgaaaaat ttttaagttt ttttcgggta tgaaaaaagc ccgcacaaaa catatagtct
     6121 gtacgagctt ttaaagctaa ataatattta ttttttaata gtgtactgtt aggtggaatt
     6181 aaattgtaaa gaattgcact taaaacattc cataactcaa gcccccttac agcaaaatac
     6241 tatgcaatgc ctaatcgaac ttattgagga aattttaaag tttctaattt tcttaaaatc
     6301 aaggattttg tttgttctct tgaatatccc atttctgcta attcatgcag acatttgatt
     6361 atctgtaaat ctgtttcttc tttcattttt gttattatac agcagttatc ttttgtaaca
     6421 aaaaaatcat ttcctttttt tacgattaac tctttctttc tcagtatttt ataagataat
     6481 tgaattgtat gtttactaac atttaattct ttacttaaat ttgttattga aagtagcttt
     6541 tgacctgctt ttaatttctg ttgaaaaatt tctcgttcta tataatttga tatttgttgt
     6601 gcataagggt aaacatcatt aagatataac tccatgtgta tcacttcctt tgttttatca
     6661 tcaataagca actattcaat gcttaatgta aattatggac tgttcctttt gggaatgtaa
     6721 ttgtcagtct tgtatattcc gtttctttag aagtaatatc caatttcaaa cctagtctat
     6781 cagataattt tttcgataaa tacagtccca tgcccgttgc atttgccttg tttctgttag
     6841 aaccagtaaa gcctttttca aatacacggg ataaatcaga cgtttttatt ccacagccat
     6901 tatcttctat cacaagcagt atatttgttc cgttgtcttg actgtatatc gtcagtttgt
     6961 tttcctgctt gtcaaaatac ttaatcgcat tttgcacgat ttgagataga atgaatgtca
     7021 gccatttttc atcagtatat acaacattct ctatgtcatg gatattgata attactttcc
     7081 tttccataag tgaatgacga aatttcagaa tgacattatg tatcacttcg tctaactgca
     7141 actgttttac aaaatagtcc ttttccgtat tttcactcct tgcatagtag agcatttgtt
     7201 ccaccaactg aaatatcttg tctgtttctt tttttaacgt gtaatttttc gtattatcga
     7261 acgtcaaaga caatgctcct atcggtattt taatttcatg ggcgaaactt tccacatatt
     7321 cttgataatc ctgcttttcc tctgtgattt taccgatttc atcattcata gatttgcagg
     7381 ctttttttag tgcgtagtaa taggcttcat tttgaaattc ttttggcttt ggtaaaacat
     7441 ctgcaatata gtaggtttct tccaatccgt ctactaaatc aataatatgt tgcgaagcct
     7501 tacgtttctt ccgatacaaa caccattgaa aaagcccttg tatgctgatg aacagaatta
     7561 ccagcaatac aacaaatagc gtatctacac cgtagaaaat caagagaaat gctactaagg
     7621 caagaaagaa aagctgaaac aatatctctg ttattttttc ttctaagaat gtaaaaaagc
     7681 tcacagtttc caaccctttc ctcgtatatt ttccaataaa tgaacaatac cgatttcttt
     7741 cattttcttt tttagacggg tcatattaac cagtaataca ttttcgtcta aataatattt
     7801 gtcgttccac agcttttcca atagttcttc cttactgata actttatctt cgttcataaa
     7861 gaagtagtat aaaatacgaa attcatttct tgtcaattca atgcttttct cttgatactt
     7921 caaaatagat aaatgtaaat caagggtaca atctttttta acaagctcac ggaaattatt
     7981 cgggtttgat aactgcaatg cacgcttgat cttctcaaga agaataagcg tgtcatacgg
     8041 ctttgtgata aagtcaattc cacccacttg aatacttttc aattcgtcag catttgtatc
     8101 tctgcttgtt acaaagataa taggtactgg catagcttgt tttattttcc tgcatacttc
     8161 atagccattt tcatacggca ggttaatatc aagcaaaacc agctctacgc aatattgctt
     8221 taattcctct gtcagatttt caaagttagt caacaagact gtttcatatc cttgtgtgtt
     8281 caatagttta gaaagctcca gacgagtgat ttcatcatct tcgataattg ctattctcat
     8341 ttccacaccc ccttgattta ccaatataat aattccacag caggagagca agaaaaatct
     8401 aactctcctc attgatattt cgtttgaaac cgatatacgt tgctatccaa taaattccat
     8461 agataaagaa gaaaatcgcc aaacctacta cgaagtaaat taaataacta tactcacttt
     8521 ctaaataaat tttataaaca ttattgactg ataccagcat aaagaaactt gcaagaattg
     8581 aataaataac tggaacacca aataatatta gtaattgctt tctgattgtt ttaaataatg
     8641 atttatcatt cactcccaat ctttttaatg tttgatagcg atatttgtac tttgtagagt
     8701 cacttagtga ttgaatagca agaactgttc caactgccga aatcaaaata aaggcaatat
     8761 aaagacaaat gcttgcaatc atagcggtca tcgtattttg ttcttcaata gcagaacctc
     8821 ttacagaaag tctataatat tgtacgactg tttcaccatc atcatttact attactaatc
     8881 gatgtttcaa atcttgtttg attttttctc taagttttgt atctgtttct tctatggtat
     8941 ctataatcag atgttgctca gatacttcca agccttgaac atattcatca ggcacaataa
     9001 cagcaaatct tccagtatta tttatttgat accaatacgt ttttgtatca atgcccttta
     9061 gttttaattc ttttccactt gtcaactgaa ttttttcaat atccttgttg ttttcaactt
     9121 tatataacaa atctttgcta gttacaagaa aatactcgtc attacttaat tctatggtgt
     9181 ccatattctt taatttcagt atttcgttat aatcacttaa tttcattact gggtcataat
     9241 cataaaattg cacgtcaaaa taattctgca tttgatgttt cggttcttta taaacatcaa
     9301 attcgattgc tttatttatt gtataatctt catcaacaac attcacatat tctttaaaat
     9361 ctttaaatgg ttgtttttct tcaaacacat gaacatcaaa cggagctgtc atttctatgc
     9421 ttgctttata cactccttta ttgatacttg aaaaatttaa acataacaaa gaaagtaata
     9481 tcaacatgga aagtgtcccg aacgtaaaac tcattgttct tgcttttgac gcaaaagttc
     9541 ttgttacaaa aaggttatct ttttgatatt taagtttttt atttttcaat aaaaccgaca
     9601 acaacatatc tgcacaagta gctgatacac cataaatact gataatcaac atcatcatgc
     9661 taatcatcaa atacgtaaga gtttcttgtt taccgctgtt ttccattgtc caacgtgaag
     9721 cccaaagcaa aatagcagta attcctaata taacactaac aatgaaaata atatttctct
     9781 ttttattgct acggaacatt ttcttttcat tctgcttatc aaaataaaga aaatcatgta
     9841 ccgtcatttt tctaattctt cgtaaaagat taagcagaac caatacgtat attgccaaaa
     9901 agtaaatagc aagcaatcct atggaaacaa aatttattga aataaagatt acttctggaa
     9961 tacctaataa gtttacaatt accaatgata caaattgact aaatatgaac ccaagaggaa
    10021 tagccaaaac caaagcacat atcgctaata acacattttc aattacaagc aatcgagcaa
    10081 tttctttttt tctaattcca agaagcatat atgttccaag ctctttgctt cgcttttcaa
    10141 acataaattt tgtggtgtag ttaatcaaaa aacagataac aaatataata acaacattca
    10201 caaaagctag aatatactta aacgtatcca tgcctgtcga taattctatt acttcttcag
    10261 aacttgccac taagttaaaa gcaaatataa gagaaaatgc gatagtaaca gttatcaaat
    10321 aaatcaaata atctttaatg cttctttttg tatttctaac cgctaattta cctaacattt
    10381 cccacttcac ctccgagcaa ggttaatata tccagtattt cattgaagaa atcttttctg
    10441 cttttttccc ctctgaaaat ttcattgaat attttaccgt ctttcaagaa caaaatacgt
    10501 ttacaaaaag acgcactaaa cgggtcatgt gttaccatta aaatagtagc ctgcattttc
    10561 ttgttgatgt cagacattgt ttccagtaac aatctggaag attttgagtc caaagctccc
    10621 gtcggttcat cagctaatat cagtttcggt tcattgatta aggctcttgc acaagcacaa
    10681 cgctgttttt gtccgccaga aacttcataa ggaaatttcg ataaaatatc acgaataccc
    10741 aatttatcag cgatagcatg aactcgtttg tcaatatcag cagggttctg tttgttgatt
    10801 accaatgaca aagaaatgtt ttcttcaatc gttaaggtat ctaaaaggtt gaaatcttga
    10861 aaaatgaacc ctagattttc acgtctgaaa tcagcaaaat ctttatcttt gattttggta
    10921 atatcttgat tgttgactgt aatgtgtccg ctggttacgg tatcaatcgt agagatacag
    10981 tttaataggg tagtctttcc agaaccacta gctcccatta ttgcgacaaa ttcgcccttg
    11041 tctacataca tagaaatacc gtctactgcc tttgtgatat ttccagagtt acccccgtag
    11101 tattttttta cttgttctaa atttaaaatg tgttccatta aaatcgctcc tttcttcctg
    11161 ccacatttat ttgttttgga atacgattaa attatagcaa gggcagtatt caattacact
    11221 tacagttttg aaagtaaaca gagagtaaaa gagccgtgat aatgcagatc acaattctgt
    11281 gaagcatttt cacgacccgt tactttcatt gtctaaaaaa ttacaattac aaacctttta
    11341 taaatagtcg taagaaacca attcttccat aggaatacgt gtagcaaaat gacgttctgg
    11401 gtctgctggt gtttctttcc cataaccaat gactaatata ttgactggtt ctaaattatc
    11461 tggtaattga aattctcgtt tgattacatt tggtttaaaa aagcataccc aaactgtacc
    11521 taatcccaac tctgttgcct gcaacatcat gtggtctgtc aaaatagtag cgtcaatatc
    11581 tgttgtctgt ttgttatcaa aaggtcgttt ccacgctttt gaatggtctg cacaaacaat
    11641 aattgccaat ggagcattat atatatttcc agcttttgca atgcttttca atcgttcttt
    11701 gtcctgcacc accaacaatt taactggctg taagttcgcc gcagttggtg caacatgagc
    11761 agaagcaagt attttatcca gcttttcttt ttctacgggc ttatcttcgt atgttctaac
    11821 ggaatatctc ttttttgcaa tatctaatac attcattttt ttaatctcct ttgttcttgt
    11881 gaattaggtc aacctatact ataattatat ccgtaatagt ctattggaca agaacgcact
    11941 attttgtaat atactaccta aaaagaaagt gagagaacat catggaaaat aattgttgtg
    12001 gttttagttg tcccgttgaa gcaaccattc aactaatcgg cggaaaatat aaagcggtca
    12061 ttttatggca cttaatgaat aaaacattac ggtatagtga aattcataag ctcattccaa
    12121 aagcaacaga caaaatgtta gcacaacagc ttcgtgaact ggaaaaagac ggattgatta
    12181 accgtaaggt ttatcctgtc gtcccaccaa aaacagagta ttccttaact gaatttggaa
    12241 aaaccttaac accaattctt gatgaacttt gtaactgggg cgaaaattat ttactccaaa
    12301 actgattgta agccgtgata atcagatttc tcgctgtgag ttgtttacca cggcgttttt
    12361 atttacagct taacttttgt ttttttcgta atcttgtaaa tatattcttc tggcgtagga
    12421 cgtttattcc caaaatactt tttgaaattt gcctgcacct ctgggtctgt actgttcata
    12481 gcttcatcaa tcgtcgcttc aatatcagcc cgtatatcag ctaaagacac accgctagca
    12541 tttgcacctg ctttcaatgc tttttttata tctcgttttt taagtcctat caaaatatca
    12601 ctcctaaatt aaattttctg ttacaccaaa tgcggtatat ttcctttcaa atataccgca
    12661 taagaaaaaa taaatcaata aatgaactct cttgattatc ctacaatctt ccagttacta
    12721 tccttatgta gcacaagctc atactgtgat acctgcgttg cctttgtctg attatcgagg
    12781 aatttcacgg atactttgac tttcacattg cccccgtcct ttgtaaagat agggtttacc
    12841 agttcagaat aaaggtagtc cctgccgata ggttcaagca catttcccga tacatagtag
    12901 gcaagttctt tttctgtggc tgtcgggtac agcttaaaga atgtttccag aaatgcggca
    12961 gcgtcattga cagtatcagc gtccacgctt gcgtcggttt ctggtgtttt aggctcatag
    13021 tctgattttt cgattgctgg tgcaagggta gggttctgca cgattaccat atccccgtca
    13081 gcgtctacat ggactttcac ggtataagtt gccttgacat tgcttgtctg ttctccgtct
    13141 tttatctgct gatctacttc gtaggtggca gaaaaagtgt ccgttcccga ctgttcgata
    13201 ctccacacaa tcacatctgt aaccgtggag ctggtcggta tatccattct gattgtatcc
    13261 acattcaagt cctgcaattc ctttgtcaga taaccgctga ttgcctgcgt ccttgcttca
    13321 atcacttctt tgctgttact ccatgtgtaa taggacttcg caaagttctt tacgaaattt
    13381 tctatcccgt tggtgtcctg caagcgaagc tcaatgattt ctttttcatg ggtggtgtgc
    13441 tggtcgatag cggtaaaatt cttatacacc ccaaagctca cgcttgcgat aagcaccacc
    13501 cacaacgcaa tcacggtttt cttatgtgtg cctactttga cagtacgcac cattttttct
    13561 ttgacatttt ctgtctgttt cttattcttc ttaaacatat tttcaagtcc tttctattgt
    13621 tttactcgtc ctgcaccgat taagtgctgt tgccagtaac tactgcttag gtctgcatat
    13681 cctatcgggt cgcctgcatg atatatctgg ttattcccta cataaattgc aacgtgcgtt
    13741 acataagtac cagcgttata ggtagaatgg aaaaacacca agtccccagc ctttgcctgc
    13801 gaaagaggaa gatgttgggt agcgtcatac tgtgcttgtg ctgttctcgg taaagagata
    13861 ccagcttttc catagcacca ttgaacaagt ccgctacagt caaaagaagt gttgggattg
    13921 ctaccgccat acacatattt ccagccttga tattttaacg cttcattcat taccttttgt
    13981 gccagctctc ccgatacctg cggaacagtt aaatactgat tgactaattc gacgtagaac
    14041 atatttccat agccataccg ccagcccccg ttcttcgcaa cggctatcgg gttggtgtag
    14101 gttactttct ttccacccga tttctcacgg gcgaaaatct ctgcaagatt gtatgtatgt
    14161 ttctttcctt tacctgccac atagcccaca tagccaccgc catagttata ggactgtatc
    14221 gctacattca aatcgtcgat accttgattt ttgcaggaag aaagcaggga cgcaaaatac
    14281 ttacacccct gcttgattga actttctgta tctaaggaat taggcggtaa accaagactt
    14341 tccgaactct gcataacatc ttctgccgta ccgccacttt ctacttgaat gatagccagc
    14401 aatacattga catactcgga aataccgtat tctttggcat atttttccac cataggctga
    14461 tgtttcaaga cttctgctga taagttcata cccgtaatgc cagaagaaaa attgctgttc
    14521 tcgtcgtcgc tgtccgcact aatgaggaca ccaaagaaaa gcaccagaga aaagaggaga
    14581 ggaaacagac tgccgataag agcgatatgt ttcagtttca ttttttcttc tgtcctttct
    14641 tcgttacaag gttacgggtt ttctctgtgg tctgctggtt cttctggacg ctctgggtct
    14701 gctgaacctt tgtcctgcgg tctttggtgt aattctggcg tgtttcctgc gataccactt
    14761 tttctacatt ctgcctatgt gctatctgtg ccgactgggt cgctttccta tcagaagcac
    14821 cagaagataa cggacgctct ttgataacag ttgtcttgac tggctcactt gctttagaag
    14881 tggttgctgt ggcaggacgt ttgacttcct gcattttttc tgcactcggc tttggaatgg
    14941 ttgaagctgt ggctggtcgc tcatggggac gggtagctcc cgttgtcgct gatccgtcag
    15001 cctttcgctg tgcctgcctt gcttcttgtg ccttttgaag ctccatacgc ttgtcagcga
    15061 tattctgcct atgctgttct tgcctttcca agcgtcccgt ttgtctggac agctgttcct
    15121 gcaccatgcc acgcttaaag tcggacacgc tggactttgc cttttccttt gcggaataca
    15181 ccgcataagc ggtctgtgtc ggcatatcct tgatattctc tttgacagca tttgccttgt
    15241 ctttcacttt atttttcgta tctaagacag cccccacctt tgagcctgca cgctgtccca
    15301 tgctggaagt agatgtattg ccccgactgt cttttgtggc tgtgttcctt gtcggttttc
    15361 tgtttgaaat cgtgctacct gccaccgcac cagcaacacc gccagcagta accgcaccag
    15421 caagccgtct ttccatacgc ctagctctat gtcgcataaa cagatatggt ctgcggaata
    15481 tcctgcgtcc catgttttga ctgtcgccag cgttcaaaga gaacatactc attaagtcgc
    15541 ccagcttcat gtagatacca gcgaaacaca ctatctgtaa gaaagctacc atgaaaaacg
    15601 gatagtccgt ggatatgtta taaaacatac tggaaatgct gaacgccacc gttacaatga
    15661 gcgttattcc ggcccttgtc attatggtat taaacaccct tacgattgcc tgctttgcca
    15721 tgctttcata gctcggtatc atagaaagta gaaaactgat aggtaaaaac attgcaaaga
    15781 taataaaaag tatctggcta aacaacatca tgcccgtaag caagaataca aatatcgtta
    15841 tccctaaatt gaagaacagt aggaagaaca ccatacctaa acggttcacg acctgcggta
    15901 ttgttagatt gttgttgtca ttgtcctcga tttctgtttt cacgacttcc tctctggttt
    15961 tcccgtcctc gtcctctggg cttgccgata caagagcttc gacacggtct gttccgattt
    16021 cctctgcgtt gctgttaccg aattgcagaa gtagccacgg ctgttccact tgaatagaaa
    16081 ataggctgtc ccgtatcaag tccacgctgt ctttgccctc gctgtcagag ttggggagca
    16141 tgatttttgt tcccaagtcc aaagaagcgg tactgatgtc gcttgaaaac tcatttatct
    16201 ttttgatgta gtcgggagcg taggcaataa atgaagcgga cagcacgaac accaccacaa
    16261 agttgataac agcgtgaagt gccttgcttg tttcccgttt tatcagtccc gtataagcaa
    16321 cataaagtcc caccaccaag ataataagaa gcaggaaacc gacataaaag cccgtggaag
    16381 aaaagccgtt ctgtgttacg cctgcaaggg tctgtatgct ctttccgata ctgtctgcca
    16441 tatcgttaat aaaatcaagt ttataggctt cctgcaccac atagcccgtt gcattactca
    16501 aatataaact gatagtccag acaaagttgg taatgcaata aagcccgtac tgtactgatt
    16561 ttccaatccc gtccagccag ttccacggaa gccatgacca gctattatct acataaaaat
    16621 caagctggta gttggaaagg ggatattttg agtaaagatt ttctgcgttt atggtatcgt
    16681 ccacaagccc cgtcgcatga gccaccgtcc ccagaagtga aagcaggata agggagagtg
    16741 ccacgacaaa cagagccatt ttgagaacgt gaagtatctt cttttttgtg aacgcacctt
//
LOCUS       DAEQCW010000081        16652 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.081, whole genome shotgun sequence.
ACCESSION   DAEQCW010000081 DAEQCW010000000
VERSION     DAEQCW010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16652)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16652)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16652
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.081"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            63..761
                     /locus_tag="KRO40_002630"
     CDS             63..761
                     /locus_tag="KRO40_002630"
                     /EC_number="5.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid racemase"
                     /protein_id="HBH2093447.1"
                     /translation="MNEKLIGILAGMGPRSTAPFVDLIIDECQSQYGAKYDDEFPKMM
                     IYSLPTPFYIDRPINHELMKETIIDGLQKLESTGVNFIAMPCNSAHIYFKELKESINI
                     PILNIVEETVKKLPTISQKVTLFSTSSTFESTIYQNGIIHNGHEFIFKDEWQIKLNNL
                     IQNIKMDKENPHNIDIWNKLIEDVKNESIENIVIACTDLNVVLEKSYPSINIVDSSKC
                     LAESVVNKYLKLVK"
     gene            complement(981..1598)
                     /locus_tag="KRO40_002631"
     CDS             complement(981..1598)
                     /locus_tag="KRO40_002631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4878 domain-containing protein"
                     /protein_id="HBH2093448.1"
                     /translation="MKKIILALTTFLLAISLTACSSAKPEDTIESFFNSAKKFDFEGM
                     NKVMENNDEKYKDILKELDTKDPNAQYVLDYLKQNASKITYTIKDSEVKGDKATIKVE
                     CKFIDSTPLLQEIVAEAFTKMIGMSFSGQDLTDEKTTEMLVSIMKEKQKSVKETYVTK
                     NVEFECSKKDNKWIISSVNDAVADVLLSNLVTAGQEFSNSMNTLE"
     gene            complement(1725..2747)
                     /gene="argF"
                     /locus_tag="KRO40_002632"
     CDS             complement(1725..2747)
                     /gene="argF"
                     /locus_tag="KRO40_002632"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HBH2093449.1"
                     /translation="MNNISLKGKSFLTLKDFTKEEIRYLLTLSSYLKTKKKVGIKGDL
                     LQGKNIALLFEKTSTRTRCSFEVAAHDEGAHVTYLGPNDCHMGKKESVSDTAKVLGRF
                     YDGIEFRGFKQETVESLAKYSGVPVWNGLTDEYHPTQILADFLTVIENVDKDLNKVKF
                     VYVGDARNNMGNSLMIGCAKMGIHFVALAPKELWPNEELVKEMKEIAKKSKGDIMLTE
                     NIDDVKGADVIYTDVWVSMGEEEQYEARINQLKDYQVNMDMIKKTENENVIFLHCLPA
                     FHDLETKVAQEIYEKFGLSELEVTNEVFNSKYSKVFEEAENRMHTIKAVMVSTMTDVN
                     MNNNLV"
     gene            complement(2851..4038)
                     /locus_tag="KRO40_002633"
     CDS             complement(2851..4038)
                     /locus_tag="KRO40_002633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase family protein"
                     /protein_id="HBH2093450.1"
                     /translation="MNNDNTISKWNEYFIDTYNQPNFVIDYGEGSCFFDTNGNKYIDF
                     TSGYGVSSLGYSNSNLKNALKEQVDKLLHTSNLYFNEPVLCSGEKIINSSGMAKVYFC
                     NSGTEANETAFKIARKYSSDKYGNGRGTIISLKDSFHGRTMMSLMATGMDKYHKYFYP
                     LPEGFKYIERNNIEDLKNNLDSTVCAIILEAIQGEGGVNVLEKDYVLEIVKICQEKDI
                     VVIFDEVQCGIGRTGKLFGYEYFDVKPDIVTVAKGLGAGIPVGGVLVNKKLSKVLGKG
                     DQGTTFGGNLLAMVAASVVLDEISKDGFYNEVLEKGNYIRKSIESFNNKVVLKTKGIG
                     LMIGIETNIESSIIEEKARKKGLLILTAGKNVLRFLPPLTISYKEIDEALEILKDILL
                     EIN"
     gene            complement(4068..4928)
                     /gene="argB"
                     /locus_tag="KRO40_002634"
     CDS             complement(4068..4928)
                     /gene="argB"
                     /locus_tag="KRO40_002634"
                     /EC_number="2.7.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylglutamate kinase"
                     /protein_id="HBH2093451.1"
                     /translation="MINIEKANTLIEALPYIEKHQGKTIVVKYGGSAMKKDGLKESVM
                     EDLVLMSYVGINIVLVHGGGAEINKMLAKVDIESKFVNGLRYTDEETMEIVKMVLAGK
                     VNKDLVNKIHTKGGKAVGLCGIDNNMILCDPYKNYELGFVGEIKKVNVELIESCLKSG
                     YISVIATIGVGDDGETYNINGDTAASAIAKELNADKLILLTDVPGLLREPDEEKSLIT
                     EVILEDVDKLFEEGIITGGMIPKIEGCVDALNNGVNRVHILDGRVPHSIITELFTDSG
                     IGTLIRKENE"
     gene            complement(4943..6160)
                     /gene="argJ"
                     /locus_tag="KRO40_002635"
     CDS             complement(4943..6160)
                     /gene="argJ"
                     /locus_tag="KRO40_002635"
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="HBH2093452.1"
                     /translation="MEIIKGGVTVSEGFFASGIHCGLRKNKEKRDLALVYSDVLCDAA
                     AVVTQNKVKGNPVYVTQEHIKNGKAQAIIVNSANANTFNGKEGLINAYKMAKFTSDKL
                     NIKESDVLVASTGVIGKPLNIDLIEENMDELVNNLSKQGHIGAREAIMTTDIIKKEIA
                     VAIMYGDKKITIGGMAKGSGMIHPNMATTLGFITTDANIDGVLLKEALKIAVDKSFNR
                     VSVDGDTSTNDMVMILANGKAKNDRINKKDEHYQVFLSALTYVCIELAKLVAKDGEGC
                     TKLIECYINGALSEEHAVKLAKTVISSSLVKTAVFGADANWGRILCALGYAGEEIDME
                     KVDIIFESMKGYIEVCKNGNGLDFNEEKAKKILEDDEISILVDLNMGNARGNAWGCDL
                     SYDYVRINGSYRN"
     gene            complement(6201..7235)
                     /locus_tag="KRO40_002636"
     CDS             complement(6201..7235)
                     /locus_tag="KRO40_002636"
                     /EC_number="1.2.1.38"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="HBH2093453.1"
                     /translation="MNKIKVGIIGATGYVGAELIRLLMNHDKVEVTAIGSNSYVGKDI
                     VDIYPSIGYKNNMICIENEKVIDMCDVVFTALPHGVSEKFVIKAIKSKKKVIDLGADF
                     RIKDEEVYSKWYGVSFIDKILHKKAVYGLSEIYKEDIKDADIIANPGCYPTSISLPLM
                     PLLSSKLIKNNNIIIDSKSGLTGAGRELSISSHFTEVNENITAYKIGKHRHTPEIEQN
                     LSESCKEKVSVVFTPNLIPVNRGILSTIYCTKEDNISINDIHRKLTDYYEFKEFIEIL
                     PLDKVASLKNVRFSNKCVISLHENGDTLIICSAIDNMIKGSAGQAIQNMNIIFGIEEN
                     TGLKNIAPSF"
     misc_binding    complement(7489..7702)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(8005..9096)
                     /gene="ytvI"
                     /locus_tag="KRO40_002637"
     CDS             complement(8005..9096)
                     /gene="ytvI"
                     /locus_tag="KRO40_002637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBH2093454.1"
                     /translation="MNEQDHTSYQNKQRFLINFCYLVVILGLLMLLGKYAFSVLLPFV
                     FAFLIASLLNKPVLYISEKLLIKRGIVATISVFLFFLIAGIIVSVIGTYLIYGIKEIF
                     HFLPTMFEELVIPLTETVIKEVELFSGSFNFSFIELIEANMPVLMNEMSVFIVSLSNN
                     IVSGITDIVSSVPLLFMKTIITIVASIFIAIDYPTIKRFIVLQIPKNKSYLLAEAKAF
                     TIDTIIKCGFSYLLIFAITFSELYVGFVIINISYAGIIALFIALLDILPVLGTGSILI
                     PWCIISLFLGDYSMALGIALLYIVITIIRNIIEPKLVGKHMELHPVLALASMLTGLHF
                     FGFIGLFGIPLLIAFLKKLNDKEIIHILH"
     gene            complement(9111..10502)
                     /locus_tag="KRO40_002638"
     CDS             complement(9111..10502)
                     /locus_tag="KRO40_002638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase family protein"
                     /protein_id="HBH2093455.1"
                     /translation="MKRRLAGEWEPIKGVMLAWPPFLPHKYIVDLTQNYSVYMCVPNK
                     EEIEIAKYYLSKWGGNLKNLIFCIAPQGFDTPWVRDWGMHPIFDENGKLFLAGAEYKM
                     STPFVSINKPEIMFDCEHNLLTTNSYEQKEDQSQELIAKQIGLPFMKLPYALTGGNLM
                     SDGFNKLMSMHILQTENRAKGISDEEFFSMVARDTGMNEYYIFSNFANYGLQHIDCYL
                     KIIDEETLLVSRTPKEHYLYERYEKILEEVKKVESRYGRPFKIFRIDIVPFQKDSDEL
                     TAYVNSVILNSRVYVPMYGIEQDKIAIKQWQNALPGYEIKGYEFDFEKEPDIIKNRTG
                     YVRTGWGNEDVIHCRTRAIWDENMLYISVKRLEEIVSENDALEVTIQIVDYSKAGLDY
                     ENCRLFYRYYGFQTWESIRLEETTEAEIFFANMIGKSGDMIEYFVQAKSCSGMCETMP
                     PVAPKGTYKVTIK"
     gene            complement(10521..11060)
                     /locus_tag="KRO40_002639"
     CDS             complement(10521..11060)
                     /locus_tag="KRO40_002639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093456.1"
                     /translation="MSLTIQKVTSYFKDLEKFEELNNEAFPDEERMSIQEMLNLVQSK
                     KIEVSALYDKQQFIGFYVLMIENHIGYILFLAISPEQRSKGYGGKALSLMKKQYPNCQ
                     IVLDMETIEDSAPNLQQRILRKQFYLQNGFYETEYLMEYKGLEMEVLCNQKTFQKNEF
                     ETLLKNLKIREIPFHLWKK"
     gene            complement(11081..12406)
                     /locus_tag="KRO40_002640"
     CDS             complement(11081..12406)
                     /locus_tag="KRO40_002640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009295908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2093457.1"
                     /translation="MIQLSDNFNYKRLLKFTFPTIIMLVISSIYGVVDGYFVSNFVGK
                     TAFTAVNFIMPFLLILGCVGFLFGTGGGALIAKTMGEGKKEEANEQFSLLIVTSAGCG
                     IILAVLGIVTMPWIASAMGADGQLLTDSILYGCVVIIAIPAYILQCEFQCLFATAEKP
                     KLGLYVAIMAGITNIVLDALFITVFKWGLVGAALATAIGQYVGGIIPLLYFSRQNNSL
                     LKFKKPKFDCDVLKKTVANGSSELMTNVSTSVVSMLYNAQLLKYAGEDGVASYGVLLY
                     VALLFQAVFIGYSVGTAPIISYHYGAKNYDELKNLRKRSLIVIICFAVFMFIIGEFLS
                     KPIAFIFVGYDNNLMEMTLRAFMIYSFSFLFSGFGVFGSSFFTALNDGLTSALIAFMR
                     ILVFQVVSVLIFPIFWGVNGIWFSIVGAEILATIMTAFFIIRKQKKYHY"
     gene            complement(12403..13026)
                     /locus_tag="KRO40_002641"
     CDS             complement(12403..13026)
                     /locus_tag="KRO40_002641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidylate kinase-like family protein"
                     /protein_id="HBH2093458.1"
                     /translation="MKIITISREFGSGGRELGKQLADILNFDYYDKEIITAIARKKKI
                     DENYVSYILENHGWRNVPLTMCTSFTNILSMQSMKTDLLIEQSNVINQIASTGKDCVI
                     VGRNADILLKKYQPFNVFVCANMNFKIQRCIEKKLNNEHISKKELERKIREIDKNRAR
                     SREFFTSSLWGNQTSYHIIVNTSEWNIKHLSYAIANFSEYWFRRYEQ"
     gene            13118..13927
                     /locus_tag="KRO40_002642"
     CDS             13118..13927
                     /locus_tag="KRO40_002642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2093459.1"
                     /translation="MIKKLYKTSEFAELCGVKKHTLYHYDEIELLKPSITHENGYRYY
                     TIDQFEKFNIISVLKKAGTPLEEIKQYLNDLDTNTFLNVLHRKLMDLQEEVKKIEKMC
                     SMLRNVISTMEIHLNVNTEKIEIVNCEEEYLIATKIPEAVLTDEKTMLQGIGNHLQYC
                     LLHDYNFHVGEIVLEKNIKQGIFRESYYYSLIKNKVDDERLFIKPKGNYAVMYHQGSY
                     DSLYKTYQNMKNQLEEQGYHIVGNIYEEDLIDYLSEHNAENYIQKISMQVI"
     gene            14361..14723
                     /locus_tag="KRO40_002643"
     CDS             14361..14723
                     /locus_tag="KRO40_002643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093460.1"
                     /translation="MEIDYKAIGQRIKIARIKKGITQESVANIINMTPSHMSNVETGK
                     TKVSLPTLIAIANALSVSVDTLLCDNVLSSKVIFEKEAKDIFSDCDEYEIRSLVELLK
                     SAKTVIRKDREIRKQFEK"
     gene            complement(15073..15630)
                     /locus_tag="KRO40_002644"
     CDS             complement(15073..15630)
                     /locus_tag="KRO40_002644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093461.1"
                     /translation="MRVSREIVIQATSDIVNKDGLNKVSLKVIAEKLGIRTPSLYNHI
                     ESLDDLLLEVAHKGMREMNSQMIKAAIGNFGDTAIKCISIAYFNFIISNPGVYETIQW
                     ATWHGNNETLEIFDEYKSLLEKLILSCNLNTKNTGEVLNLIMSVLHGYSTLQLGKSLL
                     SKEEAIKGLVDSIDTVLLGIHKKYD"
     gene            15888..16586
                     /locus_tag="KRO40_002645"
     CDS             15888..16586
                     /locus_tag="KRO40_002645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2093462.1"
                     /translation="MEKKYFEIHGVPSILWGNPSSKLYIYIHGQCGNKEEAEAFANIA
                     VPHECQVLSVDLPEHGERKREKNSFNPWHVVPELVSIMEYAKCHWNQISLYANSIGAW
                     FSMLSFEKENLRECIFVSPILDMQQLISNMMLWANVSEEQLKHELIIPTSFGHTLSWE
                     YLQYVKQHPITQWNVPTKILYGKHDELTEIGVVEKFVEKFNCNLTIIENGKHWFNTPQ
                     ELNSLYEWLNTLVK"
BASE COUNT         5686 a         2896 c         1883 g         6187 t
ORIGIN      
        1 tatgctttta tagattttta ttttatacat aaatatattt atatataaag gagataattt
       61 ttatgaatga aaaattaatt ggtattttgg ctggaatggg tccaaggtca acagcccctt
      121 ttgttgattt aattattgat gagtgtcaat ctcaatatgg agcaaaatat gatgatgaat
      181 ttccaaagat gatgatatat tcattaccta ccccatttta tattgaccgt ccaataaatc
      241 atgaacttat gaaagaaact ataattgatg gattacaaaa gcttgaatca actggtgtaa
      301 attttattgc aatgccatgc aattcagcac atatatactt taaagaatta aaagagtcta
      361 ttaatatacc aatattaaat attgtagaag aaacagttaa aaaattacct actatctcac
      421 aaaaagtaac tcttttttcg actagttcaa cttttgagtc tacaatttac cagaatggta
      481 taatacataa tggacatgaa tttatattta aagatgaatg gcaaataaaa ttaaacaatc
      541 ttattcaaaa tataaaaatg gataaagaaa atccacacaa tattgatatt tggaataaac
      601 ttatcgaaga tgttaaaaat gaatctatag aaaatatagt aattgcttgt actgatttaa
      661 atgtagtttt agaaaaatca tatccttcaa taaatattgt tgattcatca aaatgcttgg
      721 ctgaatcagt tgtcaataaa tatctaaaat tagttaaata aatttttcat gcactatatt
      781 ataaaaaata tatgttataa gtttatctta aatagtatag gcttataaca tatatcatag
      841 tttcttgaca atatagaaat taaccatgta tttcattata ttaataaaaa ggataccaaa
      901 aatggtatcc ttcataaata tttatatgtt tatttataaa aataatcata tatttattac
      961 tttactacac ctaaacaata ttattcaagt gtattcatag agttagaaaa ttcttgtcct
     1021 gctgtaacaa gattagataa caatacatca gctactgcat catttactga acttattatc
     1081 catttattat cctttttaga acattcaaac tctacatttt ttgtaacata agtctcttta
     1141 acgctttttt gtttttcttt cataattgat actaacattt cagttgtttt ctcatcagtt
     1201 aagtcttgtc ctgaaaaact cataccaatc atctttgtaa atgcctcagc tactatttct
     1261 tgaagtaatg gtgttgaatc tataaattta cattctactt tgattgtagc cttatcacct
     1321 ttaacctcgc tgtcttttat tgtatatgtg attttagatg cattctgttt tagataatct
     1381 aaaacatatt gggcatttgg gtcttttgta tctaattcct ttaatatatc cttatatttt
     1441 tcgtcattat tttccattac cttattcatg ccttcaaagt caaacttttt cgcactgtta
     1501 aaaaaactct caattgtatc ttctggtttt gcacttgaac atgctgttaa agatattgct
     1561 aataaaaaag ttgttaaagc taatatgatt tttttcatat ctcaaatcct ccctcttaat
     1621 ttgttgatac ataagttatt ttaacatata atgagagttt ttgaataata tatttaaaat
     1681 attttataaa ttttcattaa agtaaagtct atattaaaac atatctatac taaattattg
     1741 ttcatattta catcggtcat agtagaaacc ataacagctt ttattgtatg cattctattt
     1801 tcagcttctt caaatacctt tgaatatttt gaattaaata cctcgtttgt aacctctaat
     1861 tctgataatc cgaacttttc ataaatctcc tgagcaacct tagtttctaa atcatgaaat
     1921 gctggaagac agtgtaaaaa tataacattt tcattttcag ttttctttat catatccata
     1981 tttacttgat aatctttaag ttgatttatt cttgcttcat attgctcctc ttctcccata
     2041 gaaacccata catctgtata tataacatct gcacctttaa catcatcaat attttcagtc
     2101 aacattatat ctcctttgga tttcttggct atttccttca tttccttaac caattcttca
     2161 tttggccaaa gttccttagg tgctagtgct acgaaatgta ttcccatttt agcacatcct
     2221 atcatcagtg agtttcccat attatttcta gcatcaccaa catatacaaa tttaacttta
     2281 ttcaaatctt tatctacatt ttcaattact gttaaaaaat ctgccagtat ttgtgttgga
     2341 tgatattcat ctgtaagtcc attccaaaca ggtacaccag aatattttgc tagactttca
     2401 actgtttctt gtttaaagcc tctaaattct attccatcat agaatcttcc tagaactttt
     2461 gctgtatctg atacagactc ttttttaccc atatgacaat catttggacc tagataagtt
     2521 acatgtgctc cttcatcatg agctgctact tcaaatgaac atctagttct tgttgatgtt
     2581 ttctcaaata ataaagctat attttttcct tgtagcaaat cgccttttat accaactttt
     2641 ttcttagttt ttaaataact tgataaagtt aataaatatc taatctcttc ttttgtaaaa
     2701 tcctttaatg tcaaaaaact cttacctttt aaacttatat tattcatatt aattcgcccc
     2761 ttcttataaa ctttttaaat tcaattaaac ttgttagcac tttacttttt tatttacttc
     2821 taatttttta attaactatt ttttgaatat ttagttaatt tctagtaata tatcttttag
     2881 gatttcaaga gcctcatcta tttccttata actgattgtt aatggtggta aaaatctcaa
     2941 tacatttttt ccagcagtca aaataagcaa tccttttttt ctagctttct cttctataat
     3001 actagattca atattagttt caattcctat cattagacca ataccttttg tctttaatac
     3061 aactttgtta ttaaaacttt caatagattt tcttatataa tttccttttt ctaatacttc
     3121 attataaaaa ccatctttag atatctcatc taatacaact gaagctgcca ccatagctaa
     3181 taaattacct ccaaaagttg taccttggtc tccttttcct agtacttttg aaagtttttt
     3241 atttaccaat actcctccta ctggtattcc tgctcccaac ccttttgcta cggtaactat
     3301 atctggtttt acatcaaaat attcatagcc aaaaagttta ccagttcttc ctataccgca
     3361 ttggacttca tcaaaaatca ctacaatatc cttttcttga catattttta ctatttccaa
     3421 aacataatct ttttcaagaa cattaactcc accttcgcct tgaatcgctt caagaattat
     3481 tgcacaaact gtggaatcaa gattattttt taaatcttca atattatttc tttctatata
     3541 tttaaaacct tcgggaagag gataaaaata cttatggtat ttgtccatac cagttgccat
     3601 taaagacatc attgttctac catgaaaaga gtcttttaaa cttatgatag ttcctctacc
     3661 attaccatat ttgtcactac tatactttct tgctattttg aatgctgttt catttgcttc
     3721 tgttccagaa ttacaaaaat atactttagc cattccactt gaattaatta ttttctctcc
     3781 tgaacacaac actggctcat taaaatataa atttgaagta tgtaataatt tatctacttg
     3841 ctcttttaga gcattcttta aattactatt actataccca agagaagata ctccatatcc
     3901 acttgtaaaa tctatgtatt tattgccatt agtatcaaaa aaacaacttc cttcaccata
     3961 atctatgaca aaattgggtt ggttatatgt atctataaaa tattcattcc attttgaaat
     4021 tgtattgtcg ttattcattc ttattctccc ctcttaaact tataatttta ttcattttct
     4081 tttcttatta atgtacctat tccactatca gtaaatagct ctgttattat agaatgtgga
     4141 actcttccat ccaaaatatg taccctattt actccgttat ttaaggcatc tacgcatccc
     4201 tctattttag gtatcatacc tccagtaatt ataccttctt caaataattt atcaacatcc
     4261 tctaatataa cttctgttat taatgatttt tcttcatctg gctctcttaa caaaccaggg
     4321 acatctgtaa gaagtatcaa tttatctgca tttaactctt tagctatagc agaagctgct
     4381 gtgtcaccat ttatattata agtctctcca tcatctccaa cacctatagt tgcaattact
     4441 gaaatataac ctgactttag acaagattct ataagctcaa catttacttt tttgatttct
     4501 cctacaaatc caagttcata atttttatat gggtcacata aaatcatatt attatctatt
     4561 ccacaaagcc ctactgcttt tccacctttt gtatgtattt tatttactag gtctttatta
     4621 acctttccag caagtaccat ttttacaatt tccatggtct cttcatctgt atatctaaga
     4681 ccatttacaa atttactttc tatatccact tttgctagca tcttattgat ttctgcccct
     4741 ccaccatgta ctaaaactat attgattcca acataactca ttaacacaag gtcttccata
     4801 acagattctt ttagaccatc ttttttcatt gcacttccac catacttaac tacaatagtc
     4861 tttccctgat gtttttctat atatggtaaa gcttctataa gtgtatttgc tttttctata
     4921 ttaatcatta aagtatatcc tcctaatttc tataacttcc atttattctt acataatcat
     4981 agcttaaatc acatccccat gcatttcctc tggcattgcc catatttaaa tctactaata
     5041 tacttatttc gtcatcttca aggatttttt ttgctttttc ctcattaaaa tctaatccat
     5101 ttccattttt acatacttca atatatcctt tcatactctc aaaaataata tcaacttttt
     5161 ccatatctat ttcttcacct gcataaccta aagcacacag tattctaccc caatttgcgt
     5221 cagctccaaa tacagctgtc tttactaatg aagaagatat aactgttttt gctaatttta
     5281 ctgcatgttc ttcacttaat gctccattta tatagcattc aattagtttt gtacatcctt
     5341 ctccatcttt tgcaacaagt ttagcaagtt ctatacagac atatgtaagt gcactcaaaa
     5401 atacttgata atgttcatct tttttgttta ttctatcatt ttttgctttt ccatttgcta
     5461 gaatcattac catatcatta gtacttgtat ctccatctac actaactcta ttaaaacttt
     5521 tgtcaacagc aatttttaaa gcttctttta gcaaaactcc atcaatattt gcatctgtag
     5581 ttataaatcc taacgttgtt gccatattag gatgtatcat gccagaacct tttgccatac
     5641 ctccaatagt tattttttta tctccataca ttattgctac tgctatttct ttttttataa
     5701 tatcagttgt cataatagct tctcttgctc caatatgacc ttgtttactt agattattca
     5761 ctaattcatc catattttct tctattaaat ctatatttaa tggctttcct ataacacctg
     5821 tagatgcaac caaaacatca ctttctttaa tatttaattt atcactggtg aatttagcca
     5881 ttttataagc atttataagt ccttcttttc cattaaaggt attagcatta gcactattta
     5941 ctatgatagc ttgtgccttt ccatttttaa tgtgttcctg tgtaacataa acaggattgc
     6001 cctttacttt attttgagtt actactgctg ctgcatcaca taaaacatct gaataaacca
     6061 aagctaaatc tcttttttct ttattttttc tcaagccaca gtgaatccct gaagcaaaaa
     6121 atccttctga aactgtaact ccacccttta taatctccat atttatcctc ctaattatat
     6181 gagtttagta ttttttattt ctaaaatgat ggtgcaatat tttttaaacc tgtattttct
     6241 tcaataccaa atattatatt catgttttgt atagcttgac ctgctgatcc cttaatcata
     6301 ttatctatag ctgaacagat tatcaatgta tctccatttt catgtaatga tattacacat
     6361 ttatttgaga atctaacatt ctttaaagaa gctaccttat ctaatggaag aatttctata
     6421 aactctttaa attcataata atcagttaat ttcctatgta tatcatttat agaaatatta
     6481 tcttcttttg tacaatatat agttgataag attcccctat ttactgggat taagtttggt
     6541 gtaaaaacta cacttacttt ttctttgcag gattcactta aattttgttc tatttctgga
     6601 gtatgtctgt gtttccctat tttatatgca gtgatatttt cattaacctc cgtaaagtga
     6661 ctactaatcg ataattctct accagcacct gtaagacctg atttagaatc aattattata
     6721 ttattatttt ttatcaattt agaacttagt aatggcatca atggtaaaga aatactagtt
     6781 ggataacatc caggatttgc aattatatct gcatctttta tatcttcttt gtatatttca
     6841 cttaatccat atacagcttt tttatgtaag attttatcta taaaagatac tccataccat
     6901 ttactatata cttcttcatc ttttattcta aagtcagcac ctaaatctat aactttcttt
     6961 ttcgatttaa ttgcctttat tacaaacttt tcactaactc catgtggaag ggctgtaaac
     7021 acaacatcac acatatctat aactttttca ttttctatac atatcatgtt atttttatat
     7081 cctatacttg gatatatatc aactatatct tttccaacat acgaatttga acctatcgct
     7141 gtcacttcga ctttatcatg attcattaat aatctaatca actctgcccc gacatatcca
     7201 gttgcaccaa taataccaac ttttatttta ttcattttgt tccctccatt tttatattca
     7261 aatagtctta aaatcctatc tttccacttt actatatgat aatcatttga taatacgtag
     7321 attaaaatac tctaattaaa acaaaaaacc ccttagcatt ataaatacta agaggcgatt
     7381 ttccgcggta ccactcttat tggtaaaatt acaataatca ttaaaactca aattaaaaag
     7441 tatctacaaa atgtacattt aaaattaaaa aagcctcttg gtcaaagacc aagagacgaa
     7501 tatacacccg cgttaccact ctaattgata agataatctt acccactcta atctcttaag
     7561 gcgagattca ccaattacca tactattact tctggtaatc tcctccaaag ctctattcac
     7621 aataaaattc gttactaggc ttccaccatt cccagctctc tatcaactag ctttatgcta
     7681 ctctcttttt cacaggattt caatttattt tcttattgtt ttatatgata gtttattttt
     7741 ttaactttgt caatataatt tttaagtttt tggaaatatt ttctatataa ttaatttcca
     7801 gcattttgta tctaaattga gttataaata tctacagtaa taggacacca tgaatttcct
     7861 gctgtaatat attttaaaaa agttctccct cttgaatcaa gtcattcaaa agctatacct
     7921 ttgtcaaaat tatttttcat ccagcgtttt ttagaaaaaa cacaattttc tccataaaag
     7981 agacatacat acaactattc tttcctaatg taatatatgt atgatttctt tgtcatttaa
     8041 ctttttcaaa aacgcaatta acaatggaat accgaacaac ccaataaatc caaagaaatg
     8101 taatcctgtt agcatactgg ctaaggccaa tacaggatgt aactccatat gtttaccaac
     8161 taattttggt tcaataatat tcctgataat agtaatcaca atatatagta gtgcaattcc
     8221 taatgccatt gaataatccc ctaaaaataa actgataata caccaaggta ttagaatact
     8281 tccagttcct aaaacaggta gtatatctaa aagagcaatg aataaagcaa ttattccagc
     8341 ataagaaata ttaataataa caaaaccgac atataattca gaaaaagtga tagcaaaaat
     8401 taaaagataa gaaaaaccac atttaataat ggtatcaata gtaaacgctt ttgcttctgc
     8461 taaaagataa cttttatttt taggtatctg tagcactata aatctcttta tcgttggata
     8521 atcaattgct ataaaaatag aagcaacgat tgtaataatt gttttcataa atagtaatgg
     8581 aacagacgaa acaatatcag taataccaga tacgatatta tttgaaagag aaactatgaa
     8641 aacactcatt tcattcatca atacaggcat atttgcttct attaattcaa taaacgaaaa
     8701 attgaatgaa ccagaaaata gttcgacttc ttttataact gtttcagtca aaggtattac
     8761 caattcctca aacatggttg gtaggaaatg aaaaatttcc tttattccat atattagata
     8821 tgtacctatt acacttacta ttattcctgc aattaaaaag aataaaaaaa cagatatggt
     8881 tgctacaata cctcgcttta ttagtaattt ttcacttatg tataagactg gtttattcaa
     8941 taaacttgct attaaaaatg caaaaacaaa aggaagtaat acagaaaacg catatttccc
     9001 taataacatt agtaagccta atatcactac caaataacag aaatttatta aaaatctctg
     9061 cttattttgg tatgatgtat gatcttgttc attcaaataa aatgcacctc ctactttata
     9121 gtaactttat atgtgccttt tggagcaaca gggggcattg tttcacacat tccagaacaa
     9181 ctttttgctt gcacaaaata ttcaatcata tcacctgact ttcctatcat attggcaaaa
     9241 aatatttctg cttctgtagt ttcttctaac ctaatacttt cccatgtttg aaaaccatag
     9301 tatcgataaa acagtctaca attttcataa tctaagccag ctttactata atcaactatt
     9361 tgaatagtaa cttctaaagc atcattctct gaaacgattt cttctaatct tttcacggaa
     9421 atatagagca tattctcatc ccaaattgct cttgtcctgc aatgaataac atcttcattt
     9481 ccccagccag ttctcacata tcctgtacga ttttttataa tatctggctc tttttcaaaa
     9541 tcaaactcat atcctttaat ttcatatcca ggcaaagcgt tctgccattg ttttattgca
     9601 attttatcct gttcaattcc atacattgga acatagacac gactatttaa aatcacagaa
     9661 ttaacataag cagtaagttc atcactgtcc ttttgaaacg gaacaatatc tatacgaaag
     9721 attttgaatg gacgtccata tctgctttct acctttttta cttcttctaa aattttttca
     9781 tatctttcat acaaatagtg ttcttttggc gttctgctca caagtaatgt ttcttcatca
     9841 attattttta aataacagtc aatatgttgt aaaccataat tagcaaaatt agaaaatata
     9901 taatactcat tcattccagt atctcttgcc accatagaaa aaaattcttc gtcagaaatt
     9961 cctttcgcac gattttctgt ctgtaaaatg tgcatagaca tcaatttatt gaaaccatct
    10021 gacataagat ttccgcctgt tagtgcataa ggtaatttca taaatggcaa accaatctgt
    10081 ttcgcaatca actcttgtga ttgatcttct ttttgttcat aagagttagt agttaatagg
    10141 ttatgttcgc aatcaaacat gatttctggt ttatttatgg atacaaatgg tgttgacatc
    10201 ttatattctg caccagccaa aaagagtttt ccgttttcat caaaaatagg gtgcataccc
    10261 caatcacgaa cccatggtgt atcaaatccc tgtggagcaa tgcagaaaat caaatttttt
    10321 aaatttccac cccacttact taaataatat tttgcaattt caatttcctc tttatttggt
    10381 acacacatgt atacagaata attttgcgtt aaatctacaa tatacttatg gggaagaaaa
    10441 ggtggccatg caagcatgac acctttaatc ggttcccatt ccccagctaa acgtcttttc
    10501 atttctaata cctcactttc ttactttttc cacaaatgaa atggaatttc tctaatttta
    10561 agatttttca acaatgtttc aaattcattt ttttgaaagg ttttctgatt acataaaact
    10621 tccatttcta gtcccttata ctccatgaga tattctgttt cataaaaccc attctgaaga
    10681 taaaattgct tccttaaaat tctttgctgt aaattaggag cactgtcctc tatagtttcc
    10741 atatcaagaa caatttgaca attgggatat tgttttttca taagtgacag tgcttttcca
    10801 ccatatcctt tagagcgttg ttctggggaa attgcaagaa ataatatata tcctatatga
    10861 ttttcaatca tcaaaacata aaaaccaata aattgttgct tatcatataa agcagatact
    10921 tctatttttt tactttgaac taaattaagc atttcttgta tagacatacg ttcttcatct
    10981 ggaaatgcct cgttattaag ttcttcaaat ttttctaaat ctttaaaata tgaagttact
    11041 ttttgtattg ttaagctcat atagatacct ccaaattgat ttaataatga tattttttct
    11101 gttttcttat tataaagaaa gccgtcataa tagttgccaa tatttcagca ccaacaatag
    11161 aaaaccatat cccatttact ccccagaata tagggaatat aagtactgat acaacttgaa
    11221 atactaaaat acgcataaaa gcaataagcg cagaagttaa accgtcattt aatgcagtaa
    11281 agaaactaga accaaaaaca ccaaaaccag aaaataaaaa ggaaaaagag taaatcataa
    11341 atgctcttaa tgtcatttcc attaaattat tatcgtaacc cacaaaaata aaagcaatcg
    11401 gttttgataa aaattcgcct attataaaca taaatacagc aaaacaaata attacaatca
    11461 aacttctttt tcttaaattt tttaattcgt cataattttt tgctccataa tgataactga
    11521 ttataggggc agtaccaaca gaatacccaa taaaaacagc ttgaaatagt aacgctacat
    11581 aaagaagaac accataggat gcaacgccat cttcgccagc atattttagt aattgagcat
    11641 tatacagcat actcacaaca gatgtggaaa cattagtcat tagttctgaa gaaccatttg
    11701 caacagtctt tttcaaaaca tcacaatcaa atttaggttt cttaaattta agcaaactgt
    11761 tgttttgtcg gctaaaataa agtaatggaa tgataccacc aacatattga ccgattgcag
    11821 ttgccagtgc tgcacctacc aatccccatt taaaaacagt gataaataat gcgtctaaaa
    11881 caatatttgt aattccagcc ataattgcaa catataatcc aagttttggc ttttctgctg
    11941 ttgcaaataa acactgaaat tcgcactgca aaatataggc aggaatagcg ataattacca
    12001 cacatccata aagaatacta tctgtcaata attgaccatc tgctcccata gcagaagcaa
    12061 tccatggcat agttactata cctaaaacag ctagaataat accacaacca gcagaagtaa
    12121 caatgagtaa cgaaaactgt tcgtttgctt cttctttttt tccttcaccc attgttttag
    12181 caattaaagc tccaccacct gttccaaaaa gaaagccaac acaccctaag attagcaaaa
    12241 atggcataat aaaattgaca gcagtaaaag cagttttccc tacaaaattt gaaacaaaat
    12301 atccatcaac aaccccataa atagaactta ttaccagcat aataattgta ggaaatgtaa
    12361 attttaataa gcgtttataa ttaaaattat ctgacaactg tatcattgtt catacctcct
    12421 aaaccaatac tctgaaaagt tagcaattgc ataagaaaga tgttttatat tccattcaga
    12481 tgtattaact ataatatgat aggaagtttg atttccccat aaggagctcg taaaaaattc
    12541 tcttgatctt gctcgatttt tatcaatctc tcttatcttt ctttctaatt ctttttttga
    12601 aatatgttca ttgtttaact ttttttcaat acagcgttgt attttaaagt tcatatttgc
    12661 acaaacaaaa acgttaaatg gctggtactt ctttaataat atatctgcat ttctaccaac
    12721 aataacacaa tccttacctg tactggcaat ctgattgata acatttgatt gttctattaa
    12781 caaatctgtc ttcatggatt gcatagacaa aatattagta aaagaagtac acattgttaa
    12841 aggaacgttt ctccaaccat gattttctaa tatgtaggaa acatagtttt cgtcaatttt
    12901 tttctttcta gctatagcag tgataatttc tttatcgtag tagtcaaaat ttaaaatatc
    12961 agcaagttgt tttccaagtt ctcgtccacc acttccaaac tctcggctaa ttgtaataat
    13021 tttcataata tcttttcctc acatttcatt gaatataaaa gctttctatg ttatcctaaa
    13081 gtatctggta accctaaagt caataggaga tttaaaaatg attaaaaaat tatataagac
    13141 aagtgaattt gcagaattgt gtggggtaaa aaaacataca ctttaccatt atgatgaaat
    13201 tgaattatta aaaccgagta ttacccatga aaatggctat cggtattata caattgacca
    13261 atttgaaaaa tttaatatta tttctgtgct aaaaaaagca ggtacacctt tagaagaaat
    13321 aaaacaatat ctcaatgatt tagataccaa tacctttctt aatgtacttc acagaaagct
    13381 aatggatctt caagaagaag tgaagaagat tgaaaaaatg tgttctatgt tgagaaatgt
    13441 catttcaaca atggaaatac atctcaatgt aaacacagaa aaaatcgaaa ttgtaaattg
    13501 tgaggaagaa tatctgattg caactaaaat tcctgaagct gtactaacag atgaaaaaac
    13561 aatgttacaa ggtattggaa atcacttaca atattgttta ttacatgatt ataattttca
    13621 tgtaggagaa attgttcttg aaaaaaatat aaaacaggga atttttagag agagctatta
    13681 ttatagcctt attaaaaata aagtagatga tgaacgcctt tttattaaac caaagggaaa
    13741 ttatgcagtt atgtatcacc aggggagtta tgacagttta tataaaactt atcaaaatat
    13801 gaaaaatcag ttagaagaac aagggtatca tattgttgga aatatttatg aagaagattt
    13861 aattgattat ttatcagaac ataacgccga aaactacatt caaaaaattt ctatgcaggt
    13921 tatttgaaaa tataaaaagc gtgtatatct caaatcacat gagaaataca cgcctttttt
    13981 aatatctcgt attgtctata ataatttgct taaaatgtcc ttttttatct tctaaagttg
    14041 gtatgttatt tccaaatttt tgtagaaatt caggttcatt gctattattt gtttcctcaa
    14101 tgcaaactgc atttcctcat gaatttcaga tacagaaata gctttttatt ttcgttaacc
    14161 atttaatcag ttttttacta tctttttata aaatcttaac atggaggctt tatgcctcca
    14221 tttcttttgt agttgtctta aaagtagtgc aaattttttt cttaaatata tattatataa
    14281 attattcatt tatatagagt attatattat gctctgtaaa tagttacaat atttaaaaga
    14341 atgaaaggag aacaaaaact atggaaattg attataaagc aatcggacag cgaattaaaa
    14401 ttgcaagaat taaaaaaggt ataacacaag aatccgttgc aaacattatc aacatgacac
    14461 catcccatat gagcaacgtg gaaacaggaa aaacgaaagt cagcctgcca accttgattg
    14521 cgattgccaa tgcactttct gtatcagtcg atactctctt atgtgataat gtactttctt
    14581 ccaaagtaat ttttgaaaag gaagccaaag atattttctc agattgtgat gaatatgaaa
    14641 tccgttcttt agttgaactg ctaaaatcag caaaaactgt aatccgtaaa gacagagaaa
    14701 tccgcaaaca atttgaaaaa taaaaccaca gcttcaaggt ataaattgat atgtgttgtt
    14761 agctaaggtc ttttcttttt ttatataatc atttttatat aatcaaataa cctatccaat
    14821 aattttccaa ttactgtcct tatgaaatat caatttatac tatgatacct gtgtcgcttt
    14881 tgtctgatta tcaaggaatt ttacagctac cttttcatta tcaacgacaa cagtaaaaat
    14941 agggtttacc aattcagaaa gtaaatattc ttgaaatata ctattttcct ttcataaaaa
    15001 tgataaaatt ttattttaca tcccacgtaa tgaagtgttc aataaataag ttaaaataat
    15061 ttatttacct ccttaatcat attttttatg aatacctaat aacacagtat caatagaatc
    15121 gactagacct tttatagctt cttctttact caaaagtgat ttcccaagtt gcaaagtcga
    15181 ataaccatga agtacactca ttattaagtt taatacttca cctgtattct ttgtatttag
    15241 attacaagaa agaataagtt tttctaataa ggatttatat tcatcaaaga tttctaatgt
    15301 ttcattattt ccatgccaag tagcccactg aattgtttca taaacaccag gattagaaat
    15361 tataaaatta aagtatgcta tacttataca ctttatagct gtatctccaa aatttccaat
    15421 agccgccttt atcatttgac tattcatctc tctcattcct ttatgagcta cttcaagtaa
    15481 taaatcatct agactttcta tatgattgta caaagatggt gtacgtattc ctagcttttc
    15541 tgcaataact tttaaagaaa ctttgttaag cccatcttta ttaactatat ctgatgtagc
    15601 ttgtataact atttctctac taacacgcat gattttccct ctttcattta aaattaatta
    15661 ctttattagt ttaactaatc taattagttt cgtcaattat tgtaatttat aaaattcttt
    15721 atactattat aaaatcttga cagtttaatt ataatttaat ataatactaa ttgaattagt
    15781 tttaatacta atataattag tattatatta aattctatat tacaacatta ttttatagtt
    15841 tgattaattt aacaatcact aatatatcaa actgaaagga gatttttatg gaaaaaaaat
    15901 atttcgaaat tcatggagtt ccttcaatcc tttggggaaa tccttcaagt aaattatata
    15961 tttacataca tggacaatgt ggcaataaag aggaggctga agcttttgct aatattgcag
    16021 ttccacatga gtgtcaagtt ttaagtgttg atttgcctga acatggagaa cgtaaaagag
    16081 aaaaaaattc atttaaccca tggcatgttg ttccagaatt agtatctatt atggaatatg
    16141 caaagtgcca ctggaatcaa atttcgttat atgcaaatag cattggagca tggtttagta
    16201 tgttaagctt tgaaaaagag aacttaagag agtgtatttt tgtatctcca attctagata
    16261 tgcaacagct catttcaaat atgatgcttt gggcaaatgt atcagaagaa cagcttaaac
    16321 atgaactaat tatcccaact tcatttgggc atactctttc atgggaatat ctacaatatg
    16381 taaaacaaca tcctatcact caatggaatg taccaacaaa aatattatat ggtaaacatg
    16441 atgaacttac tgaaatcggt gttgtagaga aatttgtaga aaagtttaat tgcaacctta
    16501 ctattataga aaatggcaaa cattggttta acacaccaca agaattaaat tcattatatg
    16561 aatggttaaa tactttagtt aaataaaaaa taattatatt attaatatga ttaaattatt
    16621 tataaatgtt atttaattaa ttttatttta gc
//
LOCUS       DAEQCW010000082        16453 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.082, whole genome shotgun sequence.
ACCESSION   DAEQCW010000082 DAEQCW010000000
VERSION     DAEQCW010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16453)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16453)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16453
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.082"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            160..1221
                     /locus_tag="KRO40_002646"
     CDS             160..1221
                     /locus_tag="KRO40_002646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium/sodium antiporter"
                     /protein_id="HBH2093463.1"
                     /translation="MEKRKSIHLHKLNIYLIGGGDRLFITVVLFLVGFLLITKGADIF
                     INCTVEIGKKTNISEIILGATIVSFATTLPEFTVSLLASIDGHTTMSLGNAVGSIICN
                     TGLALGLVVFISPFNVDKKMFFSKSLLLIVSVIVLILLSLDGVITRGDSLLLIIILIF
                     YMVNNYRSVVGKSDTKNRNIKNNTIKDISTKKGKNYRGFSVLEIVKILLLFATGLIMM
                     IIGSQILIESGVIIASFLNIPQGIVSLTIIALGTSLPEIVSSITAIRKNHHEISVGNI
                     LGANILNIVSVIAVSAIPNNIPILSQNRQLDIPFMILLLLIVIIPTLKSNKLSRIQGI
                     LMLFTYFLYISILYFMYII"
     gene            1312..2925
                     /locus_tag="KRO40_002647"
     CDS             1312..2925
                     /locus_tag="KRO40_002647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH2093464.1"
                     /translation="MNITKFEDLPISEGIKKAIAEMGFEEPSPIQAQSIPAILSGKDV
                     IGQAQTGTGKTAAFSIPILETIDPNNRSLQAVVLCPTRELAIQVSTEIRKLAKYSHGI
                     KTLPIYGGQPIDRQIKSLKSGVQVVIGTPGRTIDHINRKTLKMDNVKMIILDEADEML
                     DMGFREDIEMILSKIPEERQTTFFSATMPRGILELTKRYQKDPEHIKVVRKELTVSNT
                     KQYYIETRSSNKLEVLCRLVDVYDPKLSVVFCNTKRKADELVGDLQARGYFADALHGD
                     LKQTQRDIVMDKFRNGTIDILVATDVAARGIDVDDVECVFNYDLPQDEEYYVHRIGRT
                     GRAGREGMSFTFVFGKEMRKMKDIERYTKSKLIKHNIPTITDVEEKKVGTFFAQVKQT
                     IEEGHLTKQLQWLEGFCNDEDYAMVDIAAALVKLSLGEEMKEEIIEEKPRRERGDRKG
                     GTGAKDGMIRLFINIGRNQRVQAKDIVGAIAGEVGIPGKVVGTIDIYDKYTFVEIPKK
                     DAKTVIEKMKDIKIKGNKINIEKANKKKK"
     gene            3200..5185
                     /locus_tag="KRO40_002648"
     CDS             3200..5185
                     /locus_tag="KRO40_002648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBH2093465.1"
                     /translation="MSMTYMDPRVFLILEMVLEEDTNTLEQFSNVLGVSTRTIRNYIN
                     QINRELKGGIAKIVKNEKGTYSIRIEDESKLIEIVNFNRGKLSNFINLNSPDERINYV
                     LDILTMTNNPITIDDLAEEICIGRTTLIKDLKKADRILAEYDLELKRKPNIGMILVGE
                     EMDIRLLILDRLYENYIDVLENVNQINLVKDYDIECLRDELKKLFKKEELYITEQVLR
                     DVERYIIMSVLRNLNGYKFEKIDKRFEVIRCSDEYTLGLKLKALLEKIFNIVLNEKET
                     IFLTMPLIGRKAPSTKLALSSIKINDSVKEVVDEVTSFLLETSGIDFKEDKKLIENLE
                     YHLYFALNRMRFNIRVKNPLLQEIKERYTFPYSVAKIAAMIIEEKFDLKICDHEIGYI
                     ALHFGSYFEKNSRKVLNVNRVAVVCGTGLGTAQLIRIKIGKILGESVEVNTFSDIEAK
                     ANLDLLKYYDLVFTTVDFKTDLDVPIFRVNALFNEESIKKEIENAILLKNSINLKSIK
                     KIEKNIPFIGKLIEEDKFFILNKSTFMENLEDMLEKLVHKGIIDIEFKKKVLKREKKS
                     STALDNYIALPHSVNTNGENLYLAFGILEKPVIWDTKEIRIIILMIIPDKNVDSTDLI
                     IKSYEEVLEVGRDKKMVEELAKVKSFDEFYKIITKRR"
     gene            5190..5624
                     /locus_tag="KRO40_002649"
     CDS             5190..5624
                     /locus_tag="KRO40_002649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator GutM"
                     /protein_id="HBH2093466.1"
                     /translation="MDPVIFIIASLITVYLLNIFLGYLQLKDFNKNYIELKRKGRVAI
                     GRKKGRISSGTIVLILINDDGVIVETRKMQGVTVLARVKSFEGLVGKSLEYIEKSDLT
                     VYNKLLKKAILDAVKQYITFEKNKCEDTNNLSTDEECRMEVV"
     gene            5653..6213
                     /gene="srlA"
                     /locus_tag="KRO40_002650"
     CDS             5653..6213
                     /gene="srlA"
                     /locus_tag="KRO40_002650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418408.1"
                     /note="catalyzes the phosphorylation of incoming sugar
                     substrates along with their translocation across the cell
                     membrane; the IIC domain forms the PTS system
                     translocation channel and contains the specific
                     substrate-binding site; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBH2093467.1"
                     /translation="MTQFFQVLASGADSFMNLFRAGGQQFVGFVTDIVPLLVALLVTM
                     NAIINFIGTDRVERLAKKCSANIFTRYLILPVLGTFVFANPMTLSLGRFLPEKFKPSY
                     FAAASFSCHTMNGLFPHINPGELFIYLGIANGITTLGFSTADLAVRYLLVGIVANFIK
                     GVVTDYTTKFVEKQQGIALNSDIKIG"
     gene            6277..6645
                     /locus_tag="KRO40_002651"
     CDS             6277..6645
                     /locus_tag="KRO40_002651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sorbose transporter subunit IIB"
                     /protein_id="HBH2093468.1"
                     /translation="MAFNKVKIVKGSGGWGGPLIIEPTEKKNKVVYVTGGAKPETAVK
                     IAELTGCELIDGFSQGVKDDEIACVIINCGGTLRCGIYPQKKIPTINIMKTGKSGPLA
                     MFIKEDIYVSGVKPTNVEQL"
     gene            6670..7236
                     /locus_tag="KRO40_002652"
     CDS             6670..7236
                     /locus_tag="KRO40_002652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBH2093469.1"
                     /translation="MAYDTKKKISEQSQGIVAKIGIALGNVTSTLFQAGRDTIDTLIH
                     TILPFMAFVAVLIGIINQSGIGNWVANLLTPLIGNVGGLVVLSIICSFPLLSPFLGPG
                     AVIAQIVGVLVGTEIGKGNIPPSLALPALFAINSQAACDFIPVGLGLAEAEPDTVQVG
                     VPSVLYSRFLTGAPTVLLAWLASFGLYK"
     gene            7277..7642
                     /locus_tag="KRO40_002653"
     CDS             7277..7642
                     /locus_tag="KRO40_002653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBH2093470.1"
                     /translation="MELIYSTQINKIGDNANEFLQHNMFVTFKDNAPQELENYCYIHS
                     ENNLVKEILTDDVLSINNVDYKITSVGELVNQNLSELGHITFKFTGEKDGAIGGTLYL
                     EEKEIAPIGVGTILKIIRK"
     gene            7743..8516
                     /gene="srlD"
                     /locus_tag="KRO40_002654"
     CDS             7743..8516
                     /gene="srlD"
                     /locus_tag="KRO40_002654"
                     /EC_number="1.1.1.140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sorbitol-6-phosphate dehydrogenase"
                     /protein_id="HBH2093471.1"
                     /translation="MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAE
                     EIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDRIDLLVYNAGVAVSKKITDFGYK
                     DFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
                     VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKV
                     PLKRGCRFIDVANMLTFYASKEAEYCTGQSINITGGQVM"
     gene            8864..11134
                     /locus_tag="KRO40_002655"
     CDS             8864..11134
                     /locus_tag="KRO40_002655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2093472.1"
                     /translation="MDIIKKLSHGCTLDCHDCCKFNVYTKGNNVVKIEGDKNHPYTKG
                     FICKKGMAHLDRLNHKDRIKTPMLKVDGVWKEISFDKAIEIMAEKLTYYKEKYTSKSV
                     MHYDQYGSGSVLKYIGDIFFNFYGGVSRHKGGPCWSAGMHAQKYDFGVAKSHAIEDML
                     NSKSIFVWGKNPAYTTIHTMQIIKKAKEKGIKIVVIDPIYTKTAQIADKYVQVNPGTD
                     GALAIAMAKIIVEDKLYDEEYINSYVIGFEEYKKYLSSLELSFLIDECGVKENDIREL
                     VDLYTNKYSSINVGYGLQKYKNGGNTIRAIDALGAITGQIGFSGGGVNYANKVYPSVI
                     NSDPYNSQSYGEDREFYVSNISKFIEESLKNTSNKVNYASDELDMALHKVNYISDELD
                     TTSNKVNYVSDELDITSNKVNYVSDELDMTSNKVNYVLDELDITSNKIDYISNELYNL
                     SNKSIKDNIPIKMAVITKSNMLNQLPDLVELERVFSKIEFKVCFDMFITDTATLCDMF
                     IPCTNTLESEDIIYSSMTNPYITYNERAVKPAHKLMDEYYFFMELAKKMGLNDYPFVE
                     KRTYLEKVIEPLKRFDKNLDIEKLKNNYFTIHNPVAWEDKKFETPSGKYELYSESIKN
                     LGISPTPVYISNKYKEIEDKNISFRLLTNHHADTLFSQHFMDKKSIAQAYINRRMAKK
                     VGIEDKDIVILRSKKAKINVQINIDDGVGNYIVKMYVGWWKKHGNPNSLTDTGISDFG
                     GQVTYNESMVEIIRQN"
     gene            11222..11557
                     /gene="spoIIAA"
                     /locus_tag="KRO40_002656"
     CDS             11222..11557
                     /gene="spoIIAA"
                     /locus_tag="KRO40_002656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor antagonist"
                     /protein_id="HBH2093473.1"
                     /translation="MVNYSLEHKNLYIEFMCSELDHHVANEIREEIDNLLSVNQVKNV
                     VFNFENINFMDSSGIGVIIGRYKKISNEGGRVSVINISSRVKKIFDLSGLNKIIGIYD
                     TYEEALSSL"
     gene            11571..11999
                     /locus_tag="KRO40_002657"
     CDS             11571..11999
                     /locus_tag="KRO40_002657"
                     /EC_number="2.7.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor"
                     /protein_id="HBH2093474.1"
                     /translation="MNNIMEVKFSAISENESLARVIVASFAAKLDPTVDELVDIKTAV
                     SEAVTNAIIHGYEEDSSKFVFLRCEIEGNTIKIIVEDEGYGIENVEKAMEPLYTSKPE
                     LDRSGMGFTVMKSFMDDVEVSSVKDNGTRIEMTKKINVPK"
     gene            12022..12786
                     /gene="sigF"
                     /locus_tag="KRO40_002658"
     CDS             12022..12786
                     /gene="sigF"
                     /locus_tag="KRO40_002658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigF"
                     /protein_id="HBH2093475.1"
                     /translation="MEVTVAREEKKPLLSHEETLELIEKVQNGDEEAKEILISSNLGL
                     VRSVVSRFLNIGYDREDLFQLGSIGLIKSIYKFDPKFNVKFSTYAVPMILGEIKRYLR
                     DDGMIKVSRSLKQIAVKAKMESEALTKKLGREPSIEELAKAIDVEKEDLVMAMEANFN
                     VEYLQGVIHEEEGSPICLIDKISMKGESEEEKVVDNILLKDILGRLDKRERQIIVLRY
                     FEDMTQSEIGEMLNISQVQVSRIEKKVLSKLKEYIS"
     gene            13066..13503
                     /gene="spoVAC"
                     /locus_tag="KRO40_002659"
     CDS             13066..13503
                     /gene="spoVAC"
                     /locus_tag="KRO40_002659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AC"
                     /protein_id="HBH2093476.1"
                     /translation="MDKNYKKYVDQISPKPTYLKNYTLAFIVGGIICMIGQAINDLYM
                     KVGGLDKLGASSATSITLIFIGAFLTGLGVYDLIGKRAGAGSIIPITGFANSIVSPAM
                     EYKREGYVLGVGANLFKIAGPVLVYGIGSSILCGIIYYIFKMF"
     gene            13657..14670
                     /gene="spoVAD"
                     /locus_tag="KRO40_002660"
     CDS             13657..14670
                     /gene="spoVAD"
                     /locus_tag="KRO40_002660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AD"
                     /protein_id="HBH2093477.1"
                     /translation="MKNKRIGKRTVKLENKPTIISTGTIVGPKEGEGPLKDYFDMIMT
                     DDLYGEKTWELAESKMVETASQQAIQKAGKKLSDVNYMLGGDLINQIVPASFAARELA
                     IPFLGIYGACSTMAEGLCIGSMLIDGGFADLVLSGTSSHYCTAERQFRFPLELGNQKP
                     MTAQWTVTGAGSVLLAPNGDGPKVKYVTVGKVIDEGIDDGNNMGPAMAPAAIDTIYSY
                     FEDTNDDPNSFDIIATGDLGTLGKQIAEDFLKEKGVDISKVYTDCGIEMFNLKEQDVH
                     CGGSGCGCSATVFAGYIYDKLRKKEFNKVMLVSTGALLSPTSTLQKQTIPCVAHAVVI
                     VNE"
     gene            14684..15046
                     /gene="spoVAE"
                     /locus_tag="KRO40_002661"
     CDS             14684..15046
                     /gene="spoVAE"
                     /locus_tag="KRO40_002661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AE"
                     /protein_id="HBH2093478.1"
                     /translation="MLMDYVRVFIVGGIICLIAQVMMDYFKMQTPYVMVTYVTTGVVL
                     TFLGLYEPLVKFAAAGATVPIIGFGYSLATGVIKSIQSDGFLGIFLGGTTATAGGIAA
                     AIFFGYIMSVVFTPKAKP"
     gene            15229..16245
                     /locus_tag="KRO40_002662"
     CDS             15229..16245
                     /locus_tag="KRO40_002662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH2093479.1"
                     /translation="MVTIKDIARNLGISYSTVSRCLNNNPNVSEKTKKKVVEEANRLG
                     FHFNVNARNLAKKETNRIGVIFSNNFNHQDTRKFFSDIMDSSINSIETNKYDFIIQPN
                     NNISGDSNVYKMVNGQMVDGLVIVSQSIKKEEYDFLKDNNFPHVFIYFKPSFIGEVDN
                     FFWDDNVYGGYIATKHLIDHGHKDIITVTSDDKSSKMHEDRTKGYLNAMEEANLKTEV
                     IKSKMDFESQVEFLEKYIDKIKKASAIFVQQDVPAISIIQELKTTYGINVPEDISIIG
                     YNNIELISYFRSHLSTIDDPREQVIKNGVDSLVNIINKKSTEHIPRKLYPRLIIRNSV
                     KRIK"
BASE COUNT         6595 a         1660 c         3041 g         5157 t
ORIGIN      
        1 tacataaaaa ataaaaaatt gtcgctttaa agtataaaac agattatatg ttaataatgt
       61 ggtgaaatta tacccatata taaataaaat aaaacaaata aatagctaat taaggagaaa
      121 atatttttta ttttttgttt aggataaata aattttatta tggaaaaaag aaaaagcata
      181 catcttcaca aactgaatat ttatttaata gggggaggtg atagattgtt tatcacagtg
      241 gtattatttt tagtaggttt cctattaatt actaaaggcg cagatatctt tataaattgt
      301 actgtagaga taggtaaaaa aacgaatata tcagaaatta tacttggagc tactatagtt
      361 agttttgcaa caacattacc tgaatttaca gtgtctctac ttgcttctat tgatggtcat
      421 actactatga gtttaggaaa tgcagttggt tctataatat gtaatacagg gttagcatta
      481 gggttggttg tttttataag tccatttaat gtagataaaa aaatgttttt ttctaagtct
      541 ttactattaa tagtatccgt tatagtttta attttattga gtttagatgg agttataaca
      601 agaggtgatt cattattact tataataata ttaatctttt atatggttaa taattataga
      661 agtgtcgttg gaaaatctga tactaaaaat agaaatatta aaaataacac tattaaagac
      721 atatctacta aaaaagggaa aaattataga ggtttttccg tattagaaat tgtaaaaata
      781 ctattacttt ttgctacagg attgataatg atgataatag gttcacaaat ccttatagag
      841 agtggagtaa taatagctag ttttttaaat atacctcaag gtatagtaag tttaactata
      901 atagcacttg gaacttctct gccagagata gtttcgtcga ttactgctat aagaaaaaat
      961 catcatgaaa tatcagtagg aaatattttg ggtgcaaaca tattgaatat agtatcagta
     1021 atagctgtat cagcaatacc aaataacata ccaatactat ctcaaaatag acaattggat
     1081 ataccattca tgatattatt attattaata gtaataatac caacacttaa atctaataaa
     1141 cttagtagaa tacaaggtat attgatgtta ttcacatatt ttctgtacat atcaattttg
     1201 tatttcatgt atattattta actatactgt ttaaaatatt aattgcagaa tatcctaaaa
     1261 aagtatataa tggataggtt aagattaatt gataacggag aggaataata tatgaatata
     1321 acaaagtttg aagatttacc aataagtgag ggaataaaaa aagctatagc tgaaatgggg
     1381 tttgaagaac catctcctat acaagcacag tctatacctg cgattttgtc aggtaaagac
     1441 gttataggac aagctcaaac tggtacggga aaaacagctg cttttagtat ccctatacta
     1501 gaaacaatag acccaaataa tagaagttta caagctgtag tgctttgtcc aacaagagaa
     1561 ctggcaatac aagtatcaac agaaataaga aagttagcta agtattcgca cggaataaag
     1621 acattaccta tatatggtgg tcagccaata gatagacaaa taaaatctct aaagagtggt
     1681 gtgcaagttg taataggtac accaggacgt acaatagacc atatcaatcg taaaacatta
     1741 aagatggata atgtaaaaat gattatatta gatgaagcag atgaaatgct agatatggga
     1801 tttagagaag atatagaaat gattttaagt aagattccag aagaaagaca aacaactttc
     1861 ttttcagcta ctatgccaag aggaattttg gaattaacta agagatatca aaaagaccca
     1921 gagcatataa aagttgttag aaaagaactt acagtttcaa atacaaagca atactatata
     1981 gaaactaggt catcaaataa attagaagta ttatgtagat tagtagatgt atatgaccct
     2041 aaactatctg ttgttttctg taatactaag agaaaagcag acgaattggt aggagattta
     2101 caagcaagag gatattttgc agatgcatta catggtgact taaaacagac tcaaagagat
     2161 atagtaatgg ataagtttag aaatggtaca atagatatac ttgttgctac tgatgttgca
     2221 gctagaggta tagatgttga tgatgttgaa tgtgtattca actatgactt accacaagat
     2281 gaagagtatt acgttcatag aattggtaga actggtcgtg ctggtagaga aggtatgtca
     2341 tttacttttg tatttggaaa agaaatgaga aagatgaaag atatagaaag atatactaaa
     2401 tctaaactaa taaagcataa tataccaaca ataactgatg ttgaagagaa aaaagtaggt
     2461 actttctttg cacaagttaa acaaactata gaagaaggtc acttaactaa acaattacaa
     2521 tggttagaag gtttctgtaa tgatgaagat tatgcaatgg ttgatatagc tgctgcactt
     2581 gtaaaactat ctctaggtga agaaatgaaa gaagaaataa tagaagaaaa acctagaaga
     2641 gagcgtggag atagaaaagg tggtactgga gctaaagatg gtatgattag attatttatc
     2701 aatattggta gaaatcaaag agtacaagca aaagatatag ttggtgccat agctggagaa
     2761 gttggaatac caggtaaagt agtaggtact atagatatat atgataagta tacttttgtt
     2821 gaaataccta aaaaagatgc aaaaacagta attgaaaaga tgaaagatat taagataaaa
     2881 ggtaataaga ttaatataga aaaagcaaat aagaagaaaa aataacgtat agtatacaaa
     2941 actataatta gaaaatatat aaaataatat attggatatt taaaaagcct gatgtgtttt
     3001 caaaacagat agtagataat ctgtaagagt taacagcata aggcttttct tgttttatat
     3061 gatgttataa ttttccagat tgttgtgaaa aatgtatatt agttcctttt tttcaaatct
     3121 gatttgaaaa agagaatatt aattatctat atagtttaga ttataataaa aaatgtaaga
     3181 taacaaaggg gagaaaaaga tgtcaatgac ttatatggac cctagggttt ttttgatttt
     3241 agaaatggtg ttagaagaag acacaaatac tctagaacaa ttttcaaatg ttttgggtgt
     3301 tagtactagg actatcagaa actatataaa ccagattaat cgagaattaa aaggtggtat
     3361 tgctaaaata gttaaaaatg aaaaaggtac atatagtata agaattgagg atgaaagtaa
     3421 attaattgag attgtaaatt ttaatagagg aaagctatca aattttataa atttaaattc
     3481 acctgatgaa agaataaatt atgttcttga tattttaact atgaccaaca atccaattac
     3541 catagatgat ttggctgaag agatatgtat aggaagaaca acattaataa aggatttaaa
     3601 aaaagcagac agaattttag ctgaatatga tttagaatta aaaaggaagc caaatatagg
     3661 tatgatttta gttggtgaag aaatggatat aagattatta atccttgata gattgtatga
     3721 aaattatatt gatgtcttgg aaaacgttaa tcagataaat ttagttaaag attatgatat
     3781 tgaatgtctt agagatgaat taaaaaagtt atttaaaaaa gaagaactct acataacaga
     3841 acaggtcttg agagatgttg aaagatatat aatcatgtct gttttaagaa atctaaatgg
     3901 gtacaaattt gaaaagatag ataagagatt tgaagtgata agatgttcag atgaatatac
     3961 tttaggatta aagctcaaag ctttattgga aaagatattt aatatagttt taaatgaaaa
     4021 agaaaccata tttttgacaa tgccattaat aggtagaaaa gctcctagta caaaattagc
     4081 acttagcagt ataaagataa atgatagcgt aaaggaagtt gtagatgaag taactagttt
     4141 tttattagag acctcaggga ttgattttaa agaagataaa aagcttatag aaaatttgga
     4201 atatcacttg tattttgcac ttaatagaat gagattcaac ataagggtaa aaaatcctct
     4261 tttacaagaa ataaaggaaa gatatacatt tccatatagc gttgcaaaga tagctgcaat
     4321 gataattgag gaaaagtttg acttgaaaat atgtgaccac gaaataggat atatagcatt
     4381 acattttgga agttattttg aaaaaaattc aagaaaagtt ctaaatgtaa atagggtagc
     4441 tgttgtttgt ggaacaggtc ttgggactgc acaacttatt agaataaaga taggaaaaat
     4501 acttggagaa agtgtagaag taaatacttt ttctgatata gaagctaaag ctaatttaga
     4561 tttattaaag tattatgatt tagtatttac aacagtagat ttcaaaacag acttagatgt
     4621 tccaattttt agagtaaatg cgttatttaa tgaagaaagt ataaagaaag agatagaaaa
     4681 tgcaatactt ttgaaaaata gtataaatct taagtctata aaaaagattg aaaaaaatat
     4741 cccttttata ggtaaattaa ttgaagagga taagttcttt atattgaata agagtacgtt
     4801 tatggaaaat ttagaagata tgttagaaaa attagttcat aaaggaatta ttgatataga
     4861 gttcaaaaaa aaggtattaa aaagagaaaa gaaatcttca acagcattag ataattatat
     4921 agcattgcct cactcagtta atactaatgg ggaaaatctt tatctggcat ttggaatatt
     4981 agaaaaacca gtgatttggg atacaaagga aattagaata ataatattga tgataattcc
     5041 agataagaat gtagatagta cagacctgat aataaaaagt tatgaagaag tacttgaagt
     5101 agggagagat aaaaagatgg tagaagaact tgctaaggta aaatcatttg atgaatttta
     5161 taaaataatt accaagagga ggtaataata tggacccagt aatttttatt atagcatcac
     5221 ttattacagt gtatttatta aatatttttc ttggatactt acagcttaaa gattttaata
     5281 aaaattatat tgaactaaaa agaaaaggaa gagtggcaat tggcagaaaa aaaggaagaa
     5341 tttcatcggg tacaattgtg ttgatactta taaatgatga tggtgtgatt gtcgagacta
     5401 gaaaaatgca aggtgttaca gtattggcaa gagtaaagtc atttgaaggt ttggtaggaa
     5461 agagcttaga gtatatagaa aaatcagatt taactgttta caataaacta cttaaaaaag
     5521 caatactaga tgcagtcaaa cagtacataa catttgagaa aaataaatgt gaagatacaa
     5581 ataatctgag tactgatgaa gagtgtagga tggaagtagt ttaaaaaaat atatttataa
     5641 ggaggagtta atatgacgca attttttcaa gtattagcaa gtggtgcaga tagttttatg
     5701 aatttattta gggcaggtgg gcaacaattt gtaggttttg taacagatat agtaccactt
     5761 ttagtagcat tattagttac aatgaatgca attatcaact ttattggtac agatagagtc
     5821 gagagacttg caaaaaaatg ttctgcaaat atatttacta gatatttgat attaccagtc
     5881 cttggtacat ttgtatttgc aaacccaatg acactatcat taggaagatt cttgccagaa
     5941 aagtttaaac ctagttactt tgcagcagca agcttttcat gccatacaat gaatggatta
     6001 ttcccacata tcaatccagg tgaactattt atatatctag gaattgcaaa tggtataaca
     6061 actttgggat tctcaacagc agatttagca gttagatatt tgttagtggg tatagttgca
     6121 aactttatta aaggtgtagt tactgactat acaacaaaat ttgtagagaa acaacaagga
     6181 atagcattaa attcagatat aaagattgga taattacttt aaggtataaa taaatttttc
     6241 aaataaaaag atagtgtata gaggaggata aattatatgg catttaacaa agttaaaata
     6301 gtaaaaggtt ctggaggatg gggtggacca ttgataatag aaccaacaga aaagaagaat
     6361 aaggtagtat atgtgactgg gggagcaaag ccagaaactg cagtaaaaat agctgaactt
     6421 acaggatgtg agttaataga tggattttca cagggtgtta aagatgatga aatcgcatgt
     6481 gtaataataa attgtggtgg aacattgaga tgtggtatat atcctcaaaa gaaaataccg
     6541 actataaata taatgaaaac aggaaaaagt ggaccattag caatgtttat aaaagaagat
     6601 atatatgttt caggggtaaa accaacaaat gtagagcagt tataattgag gtagtaggag
     6661 ggaagaaata tggcttatga tactaaaaag aagataagtg agcagagtca aggaattgtt
     6721 gcaaaaatag gtatagcact aggaaatgtg acaagtactc tttttcaagc tggtagggat
     6781 actatagata cattaataca tactatactg ccttttatgg ctttcgttgc agtcctaata
     6841 ggtataataa atcaatcggg tataggaaat tgggtagcca atttacttac tccattaatc
     6901 ggaaatgttg gaggtttagt tgtcttatca ataatatgtt catttccgtt gttgtctccg
     6961 tttcttggac caggagctgt tatagctcag atagtgggag tattggttgg tacagaaata
     7021 ggaaaaggaa atattccacc aagtttagca ttaccagcat tgtttgcaat aaactcacaa
     7081 gcagcttgtg actttatacc agtaggtctt ggtcttgcag aagctgaacc tgatacagtt
     7141 caagtaggag ttccgtcagt tttatattct agatttttaa caggtgcacc aactgttcta
     7201 ttagcatggt tagcaagctt tgggttatat aaatagaaga atactttata aataattaga
     7261 gagaggttca gttgatatgg aattaatata cagtactcaa ataaataaaa taggagataa
     7321 tgcaaatgaa tttttacaac ataatatgtt tgtaactttc aaagataatg ctcctcaaga
     7381 gttagaaaat tactgttata tacattctga aaataattta gtaaaagaaa tacttacgga
     7441 tgatgtgcta tcaataaata atgttgatta caaaattact tctgttggtg agttagtaaa
     7501 ccaaaatctt tcagaattag gtcatataac atttaagttt acaggtgaaa aagatggagc
     7561 aattggagga accttatatc ttgaagaaaa agaaatagca cctattggcg taggtactat
     7621 actaaaaata attagaaaat aaaatttaaa acgaatctaa tcatattata agtaaattat
     7681 agataaaagt caatttaact aatcaagtta acttttaatg tgataaaaaa ggggaaatga
     7741 aaatgagaaa agtggcttta gtcgttggag gaggaagaag tttaggtgaa tatttatcta
     7801 aacatttagc taaagtaggt tatgatgttg ctattgcaga tttaaatgaa gacaacgcaa
     7861 aaaaagtagc tgaagaaata aaaactgaat ttggttgtaa atctgtagga tatagttgta
     7921 atgccataga tgaaagacag gttataagta ctgtcaaagc tattgaaaat gattttgata
     7981 gaatagattt attagtgtac aatgcaggag tggctgtaag taaaaaaata actgattttg
     8041 gatacaaaga ttttaaattt attgtagacg taaatttaaa tgggtacttt ctatttgcaa
     8101 gagaagtatc taaagtcatg atagcaaaag gtattgaggg tagaataata cagataaatt
     8161 caaaatcagg tagagtggga agtaagcata attcaggata ttcagcaggt aaatttgctg
     8221 gagtaggact tactcaaagt ttagcgctag atttggcaga acataagata actgtaaatg
     8281 cactgatgct cggtaattta cttgattctg atatgtttga aagtttaatt cctcaatatg
     8341 cagtaaaatt gggaatacct gaatcagaag tcaagcaagt ttatatagat aaagtacctt
     8401 taaaaagagg gtgtagattt atagatgttg caaatatgct tacattttat gcttcaaagg
     8461 aagctgaata ctgcactggt caatctataa atattactgg tggacaagtt atgtaaggtt
     8521 ttatggagtg tctcaagatg aactctttag ttcatgaggc acttttttgt ataaaattaa
     8581 atatattttc agcatttaaa caatgaaaaa gaggtttatc tttattttga gatagcctca
     8641 tttttgtaat taaaaaacat agtgtttaag taaacatata agattgttag ttttttaaaa
     8701 gagaattttt taataatatt atatttatga agtattttta aacttaattt gataaaatat
     8761 agctatgttt tatatactgt agttttgagc atagaaagtt taataaatta tagtatatat
     8821 gttaattttt aataaggtaa gaaagtagaa agaaggatat tttatggata taataaaaaa
     8881 attaagtcat gggtgtacat tagattgtca tgactgttgt aaattcaatg tttatactaa
     8941 aggaaataat gtagtaaaaa ttgaaggaga taaaaatcat ccttatacaa aaggttttat
     9001 atgcaaaaaa gggatggccc atttagatag attaaatcat aaagatagaa taaagactcc
     9061 tatgcttaaa gttgatggag tatggaaaga gatttctttt gataaagcta tagaaataat
     9121 ggcagaaaag cttacatact ataaagaaaa gtatacatca aagtctgtca tgcattatga
     9181 ccaatatgga agtgggtctg tgctaaaata cataggagat atatttttta atttttatgg
     9241 aggtgttagt agacataagg ggggtccctg ttggagtgca gggatgcatg ctcaaaaata
     9301 tgattttgga gtagctaaga gtcatgctat agaagatatg ttaaatagta aaagtatatt
     9361 tgtgtgggga aaaaatccag catatactac aattcatact atgcaaataa ttaaaaaagc
     9421 taaagaaaaa gggataaaga tagtagtgat tgaccccata tatacaaaaa cagctcaaat
     9481 agcagataag tatgtacaag taaatcctgg aacagatgga gctttagcta tagctatggc
     9541 aaaaattata gtagaagata aattatatga tgaagaatat ataaactcgt atgttattgg
     9601 ttttgaagaa tataaaaaat atttatcttc attggaatta agttttttaa ttgatgaatg
     9661 tggtgttaaa gagaatgata taagagagtt agtggattta tatactaaca aatattcaag
     9721 tataaatgtt ggatatgggc ttcaaaaata taaaaatggt ggaaacacaa taagagcaat
     9781 agatgcttta ggtgctataa ctggtcaaat aggatttagt ggtggagggg taaactatgc
     9841 taataaagtt tatccgagtg ttataaattc tgacccttac aatagccaat catatggtga
     9901 agatagggag ttttatgtaa gtaatatcag taaatttata gaagaatctt taaaaaatac
     9961 atcaaataaa gtaaattatg catcagatga acttgatatg gcattacata aagtaaatta
    10021 catatcagat gaacttgata caacatcaaa taaagtaaat tatgtatcag atgaacttga
    10081 tataacatca aataaagtaa attatgtatc agatgaactt gatatgacat caaataaagt
    10141 aaattatgta ttagatgaac ttgatataac atcaaataaa atagattata tatcaaatga
    10201 attgtataat ttatctaata agtcaatcaa agataatatt cctataaaga tggctgtgat
    10261 aactaaaagt aatatgctga atcaactgcc agatttagta gaattggaga gggtgttttc
    10321 aaaaattgaa tttaaagtat gttttgatat gtttataact gatacagcta ctttatgtga
    10381 catgtttata ccatgtacaa atacactaga gagtgaagat ataatttata gttcaatgac
    10441 caatccatat ataacctata atgaaagagc tgtaaagcca gcacataaat tgatggatga
    10501 atattacttc tttatggagc tagctaaaaa gatgggatta aatgattatc cttttgtaga
    10561 aaagagaact tatttagaaa aagtgattga accacttaag cgttttgaca aaaatctgga
    10621 tatagaaaaa cttaaaaaca attactttac tatacataac cctgttgctt gggaagataa
    10681 gaagtttgag actccatctg gaaaatacga gctttattca gaaagtataa aaaacttggg
    10741 aataagtcca acacctgtat atataagcaa taaatataaa gaaatagaag ataaaaatat
    10801 ttcttttaga ttattaacta atcatcatgc agatacttta tttagtcagc attttatgga
    10861 caaaaaatct atagctcaag catatataaa tcggagaatg gctaaaaaag taggtattga
    10921 ggacaaagat attgtgatat tgaggtcaaa aaaagcaaaa ataaatgtac aaataaatat
    10981 agatgatgga gtaggtaatt atatagtaaa aatgtatgtt ggttggtgga agaaacatgg
    11041 aaatcctaat agtttaacag acactggtat atcagatttt gggggtcagg taacatataa
    11101 tgaaagtatg gtagaaataa tacgacaaaa ctagttaaat ttcattgaag gaataaaaat
    11161 ataattatag aattgattaa aagttactat ttttacaaaa ctattgaagg agggattttt
    11221 gatggtaaat tattccttag aacataagaa tctatacata gaatttatgt gctcagaact
    11281 agaccaccat gtagccaatg aaataaggga agaaatagat aacttattaa gtgtaaatca
    11341 agtaaaaaat gttgtattta attttgaaaa tattaatttt atggattctt caggtatagg
    11401 cgtcatcata ggtagatata aaaagatttc taatgaaggg ggacgagttt cagtaattaa
    11461 tataagttca cgagttaaga agatttttga tttatctggg ttaaataaaa ttattggcat
    11521 ttatgatacg tatgaagaag ctctaagttc tttgtaggga ggagtatgtg atgaataata
    11581 ttatggaagt taaattttcg gcaatatctg aaaatgaaag tttagcaaga gttatagtag
    11641 catcctttgc agctaagtta gacccaacag tagatgagtt agtagatata aaaactgctg
    11701 tctctgaggc tgttacgaat gctataatac atggatatga agaagacagt tctaagtttg
    11761 ttttcttaag atgtgagata gaaggaaata ctataaagat tatagttgaa gatgaagggt
    11821 atggaataga aaatgtggag aaggcaatgg aaccacttta tacatcaaaa ccagaacttg
    11881 atagatcagg aatgggattc acagtaatga aaagctttat ggacgatgta gaggtaagtt
    11941 ctgtaaaaga taatgggact agaattgaaa tgactaaaaa aataaatgtg cctaaataaa
    12001 gtccaaaagt gaggttttat tatggaagta actgttgcca gagaagaaaa aaaacctctt
    12061 cttagtcatg aagagactct agaacttatt gaaaaagttc aaaatggaga tgaagaggca
    12121 aaagaaatat taatatcaag caatttaggt ctagttagga gcgttgtatc tagattttta
    12181 aatataggat atgatagaga agatttattt cagttaggtt ctataggctt aataaaatca
    12241 atatataaat ttgacccaaa atttaatgta aaattctcta cttatgcagt accaatgatt
    12301 ttaggtgaaa taaagagata cttaagagat gatggtatga taaaagtatc aaggtcatta
    12361 aagcaaatag ctgtaaaggc aaagatggaa agtgaagctt taactaaaaa attaggtaga
    12421 gagccgagta tagaagaatt agctaaagca atagatgtag aaaaagaaga tttagtaatg
    12481 gctatggaag ctaatttcaa tgttgagtat ttgcaaggag ttattcatga agaggaaggt
    12541 tctccaatat gccttattga taaaataagc atgaaaggag aaagtgaaga agaaaaagta
    12601 gtggataata tattgttaaa agacatactt ggaagactgg ataagagaga gcgtcaaata
    12661 atagttctca gatactttga agacatgact caaagtgaaa taggagagat gctcaatata
    12721 tcacaagttc aagtatctag gatagagaag aaagtattgt ctaagttaaa agaatatata
    12781 tcgtgataat acttatgata tgtagaataa caaaatataa taaatatatt actaaaataa
    12841 aatgtaataa ctttttattt taagttttta aattattaaa agatattaaa ataataaaaa
    12901 gcattaaaaa agtaaaaata taaaaacaag gtgtctttat ggaaaaatag attttttctt
    12961 tattaggcat cttttttatt ttttgaccaa actttagata gtcaaaataa ataataggtt
    13021 tattttttta aaattaacaa ataatacttt agagaggtgt ttagtatgga taaaaattat
    13081 aaaaaatatg tagaccaaat aagcccaaaa cctacatatt taaaaaacta tacacttgca
    13141 tttattgtag gtggaattat ttgtatgata gggcaagcaa taaatgattt gtatatgaaa
    13201 gttggaggtc ttgataaact aggtgctagt tctgcaacat caataacatt aatatttata
    13261 ggggcatttt taactggatt aggagtctac gacctaatag gaaaaagagc tggagctggt
    13321 tctataattc caataacagg ttttgctaac tcaatagtat ctccagcaat ggagtataaa
    13381 agagaaggct atgtattagg tgtaggtgca aacttattta aaattgcagg accagtttta
    13441 gtttatggta taggttcttc tattttatgt ggaattattt attatatttt taagatgttt
    13501 tagatgattt ttatttaatt taaattttat taattatgaa gaaggtataa aatctgaaaa
    13561 tagctactaa agtaactaat tgaaaaataa ttgtgcagat ttaattaata ttaaaaattt
    13621 gaatagtaaa atgcaaaatt aaaaaggtgt gaaaatatga aaaataaaag aattggaaaa
    13681 agaacagtca agttagaaaa taaaccaacc ataatatcaa ctggaactat agtaggtcct
    13741 aaggaaggtg aaggaccact aaaggactat tttgatatga ttatgactga cgatttatat
    13801 ggtgaaaaga cttgggaatt agctgaaagt aaaatggtag agactgcatc tcaacaagct
    13861 atccaaaagg caggtaaaaa attgtcagat gtaaattata tgctaggtgg cgatttaata
    13921 aatcaaatag ttccagcatc atttgcagca agagaactgg ctattccatt tttaggtata
    13981 tatggagctt gttctacaat ggcagaaggt ctttgtatag gttctatgct tatagatggt
    14041 ggttttgctg atttagtact gtcaggtaca tcaagtcact attgtacagc agaaagacaa
    14101 tttagattcc cacttgaact tggaaatcaa aaaccaatga cagctcagtg gacagttaca
    14161 ggagcaggaa gtgtattatt agctcctaat ggagacggtc caaaagtaaa gtatgttact
    14221 gttggtaaag taatagatga gggtattgat gatggtaata atatgggacc agctatggct
    14281 ccagcagcaa tagatactat ctactcttac tttgaagata ctaatgatga cccaaatagc
    14341 tttgatataa ttgctactgg agatttaggt actcttggaa aacagatagc agaagacttt
    14401 ctaaaagaaa agggtgtaga tatatcaaaa gtttatactg actgtggtat agagatgttt
    14461 aaccttaaag aacaagatgt ccactgtggt ggaagtggat gtgggtgttc agctacagtg
    14521 tttgcaggat atatatatga taagttgaga aaaaaagaat ttaacaaagt aatgcttgta
    14581 tcaacaggag cactactttc accgacaagt acactacaaa agcagacaat accatgtgtt
    14641 gcacatgcag tagtaatagt aaatgagtag gaagtgatat aatatgttaa tggactatgt
    14701 aagagtattt attgtaggtg gaattatatg tttaatagcc caagtaatga tggattattt
    14761 caaaatgcaa actccatatg ttatggtaac gtatgtaaca actggtgtag ttttaacttt
    14821 tctaggactt tatgagccat tagttaagtt tgcagcagca ggtgcaacag ttcctataat
    14881 aggatttgga tattcacttg ctacaggagt aataaaatca attcaaagtg atggtttttt
    14941 aggtattttt ttaggaggta caactgctac agctggtgga atagcagcag ctatattctt
    15001 tggatatatt atgtcagtag tatttactcc aaaagcaaaa ccataaatct ttattaaaag
    15061 aataataagt ttttgaaata ataacttttt ataaagcagg tggatatctt ttagattcca
    15121 cctatttttt atataaagaa gcgtttacat aattgaagtt gacaattatt tacaacatag
    15181 tgtagtatta tattatcaaa ataaaatgaa gtgaagtagg ggataaagat ggtaactatt
    15241 aaagatattg caaggaatct aggtatcagt tattcaactg tttctaggtg cttaaacaat
    15301 aatcctaatg tatctgaaaa aacaaaaaag aaagtggtag aagaggcaaa tagactaggg
    15361 ttccatttta atgtaaatgc aagaaattta gcaaaaaaag aaactaacag gataggggta
    15421 atcttttcaa ataattttaa tcatcaagat actagaaagt tttttagtga tataatggat
    15481 agttctataa attctattga gactaataaa tacgatttta taatacagcc taataataac
    15541 attagtggtg atagtaatgt atataaaatg gtaaatggac aaatggttga cggattagta
    15601 attgtgtctc aatcaataaa aaaagaagag tatgattttt taaaagacaa taattttcca
    15661 catgtattta tatattttaa accatctttt ataggagaag tagataattt cttttgggac
    15721 gataacgtgt atggaggtta tatagctacc aagcatttaa ttgaccatgg tcataaagat
    15781 ataataacag taacttcaga tgataagagt tcaaaaatgc atgaagatag aaccaaggga
    15841 tatttgaatg ctatggaaga agcaaattta aagacagaag tcattaaatc taaaatggat
    15901 tttgaatctc aagttgaatt tttagaaaaa tacattgata aaataaaaaa agcttcagct
    15961 atatttgtac aacaagatgt accagcgatt tctataatac aagagttaaa aactacttat
    16021 ggtataaatg taccagaaga tatttccata atagggtata ataatattga attaatatca
    16081 tattttaggt cgcatttatc aacaatagat gacccaagag agcaagttat aaaaaatgga
    16141 gtagatagtt tagtaaatat aataaataaa aagagtacag aacacattcc gagaaaatta
    16201 tatccaaggt taataatacg aaatagcgtt aaaagaataa agtagtaagc ttttaagtat
    16261 caaacgttta ttaaaaatat tatagattat gtgaagtttt ttaacaaata atataaataa
    16321 aaattaaaag gagtaggtgt atataagtac attgtactcc tttatttatt gagatagttt
    16381 ttataatatg aatgaataat tttattcaat tatttgaaaa tccgttattt taacaatata
    16441 aattaataaa tta
//
LOCUS       DAEQCW010000083        16224 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.084, whole genome shotgun sequence.
ACCESSION   DAEQCW010000083 DAEQCW010000000
VERSION     DAEQCW010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16224
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.084"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            49..225
                     /locus_tag="KRO40_002663"
     CDS             49..225
                     /locus_tag="KRO40_002663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093480.1"
                     /translation="MFRDKMDRCTHMLTAYIGSSYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     gene            635..1273
                     /locus_tag="KRO40_002664"
     CDS             635..1273
                     /locus_tag="KRO40_002664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093481.1"
                     /translation="MSNQRKDFDITNDMFQESIPITTKIILEDMPSNDELNHVFSKGC
                     ERKMKKRKIVLITLLLIGVLLLGSILYNLFLGKTANISMLKESWNFDIPIPNKEIEVF
                     DTQDSINGDGQSYFIQGFSEKNFKKVFNLKGGIVVSKDNINEIEKYIDKFKRDSVNIN
                     KSNKNKIEEDFKKYKLEVKKDDKYIYKRNYENYVVLIIKKDEQKLYSLIWNQ"
     gene            complement(1751..3109)
                     /gene="rlmD"
                     /locus_tag="KRO40_002665"
     CDS             complement(1751..3109)
                     /gene="rlmD"
                     /locus_tag="KRO40_002665"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBH2093482.1"
                     /translation="MLSKNEMYIVDIVDIGQGGVGVGKYNGITVFVEGGLIHDKVKVR
                     INKVKKNYAVGDIVEIIEKSPFRVKRVCSDNLRDCGGCQIQDLDYNKQLEMKTNEVKQ
                     VLSRIGKLEDVEVHDTIGMDNPYRYRNKAQFPIQKNNGIPIIGFYKKKTHDVISTEKC
                     VIQHEINDKIVKIIKTYIRAYKVSIYDEKTHTGLIRHLVTKIGFTTKEVMVVLVANGN
                     KLPYLKELASVLKENIPGFKTLVVNVNQKDTNAILGRENIVIYGDGKINDYIGDLVFE
                     ISPLSFFQVNPVQTKVLYDKALEYANLNDTDTVFDIYCGIGTISLFLAQKAKKVYGIE
                     IIDDAIKDAKINAKLNNIHNAEFYVGKAEEIVPKMYREGKTANVVVVDPPRKGCDEKV
                     LETIVSMNPERIVYVSCNPSTLARDLDYLNVHGFKCVEAQPVDMFPHSTHVETVAKII
                     KQ"
     gene            complement(3284..5044)
                     /gene="pyk"
                     /locus_tag="KRO40_002666"
     CDS             complement(3284..5044)
                     /gene="pyk"
                     /locus_tag="KRO40_002666"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HBH2093483.1"
                     /translation="MLNNVKKTKIVCTLGPASQSEEVLTQLMQNGLNVCRFNFSHGSH
                     EEHKERIDMAKKVREKLNKPVAILLDTKGPEIRTGNFEDPEVFLEEGQKFTITMKDIM
                     GTKEMCTVSYKGLAEDVKSGDSILIDDGLVGLRVKEINGEDIVCVVENSGIVKNHKGV
                     NVPGVKINLPAITPKDISDIEFGISQGIDYIAASFVRKASDVLAIREVLENNNATDIQ
                     IISKIENQEGVENLDEILKVSDGIMVARGDLGVEIPTEEMPIVQKMMIKKCNELAKPV
                     VTATQMLDSMIRNPRPTRAEVTDVANAIYDGTDAIMLSGETAAGKYPVEAVKMMATIA
                     KRTEETLDYDRLLKENGTNNVTVTDAISHATCTTAVDLNASAIITSTSSGYTARMVSK
                     FRPKSPIIATTNNEKTMNKLALTWGVYPVKSSVAGNTDEVIEKAIEAARQADYIDNGE
                     LVVITAGVPVGVSGTTNLIKVHVISEEIVQGIGVGTQTVEGKVRIIKNGNACVDFNEG
                     DILVSTATDAEMNNYIEKAGAVVTENGGMTSHTAIVGINLDIPVIVSAADITNLVKDG
                     EVVTVDASRGVVYRGSTRVL"
     gene            complement(5096..6055)
                     /gene="pfkA"
                     /locus_tag="KRO40_002667"
     CDS             complement(5096..6055)
                     /gene="pfkA"
                     /locus_tag="KRO40_002667"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBH2093484.1"
                     /translation="MKTIGLLTSGGDAPGMNAAIRAVVRSAIYYGCKVYGINRGYKGL
                     LEEDLTEMNLSSVGDIIHRGGTILKSSRCEEFKTEEGRLKAVKILKKYKIDCLVVIGG
                     DGSFAGAQKLSDLGFPAIGIPGTIDNDLAYTDYTIGFDTAMNTIIDAIGKIRDTSSSH
                     ERVNIVEVMGRHCGDLALYAGLAGGAETIIVPEVEITVDEVALRLKTTQKRGKRHSII
                     VLAEGVGSASDLEKELKKESGADLRVTVLGHVQRGGSPTVSDRILASRLGVRAVELLL
                     DGKSARVVGIKENKIIDLEISEALAQKKVFDKEAYEMAKILSI"
     gene            complement(6264..9833)
                     /locus_tag="KRO40_002668"
     CDS             complement(6264..9833)
                     /locus_tag="KRO40_002668"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HBH2093485.1"
                     /translation="MNKDFAHLHVHTEYSLLDGFSRVKKLIKRAKELNMSSIAITDHG
                     CMFGVIDFYKTAIKEGIKPIIGCEVYTAARGLRDKDPNYDKYQGHLVLLAKNMEGYKN
                     LIKIVSTSYVEGFYYKPRVDMEELKKHNKGIIALSACLAGDVARALMNRNYEKAKQFA
                     LDYRDIFGEENFFLEIQDHNLPEQKEVNSGLVKLSKETGIPLVATNDVHYVNKEDSKI
                     HDVLMCIQMGKTLNDPNRMRFGSDEFYLKSREEMEELFPYALEAIDNTVKIADMCNVE
                     FDFNTIHLPKYDVPEGYTPETYLRELCFNGLKERYDNPSNEILERLNYELDVIEKMGY
                     VEYFLIVWDFINFSKENNIIVGPGRGSAAGSIVAYTLKITDIDPIKYSLLFERFLNPE
                     RISMPDIDIDFCYERREEVIDYVKRKYGDDHVAQIITFGTMGAKAAIRDVGRVLDIGY
                     NKVDKVAKEIPFALGMTIDKALDTNPNLKELYDQDPETKEIINISKQIEGMLRHASTH
                     AAGVVISKNPVDEYVPLYKHQDAITTQFTMTTLEELGLLKMDFLGLRTLTVIRDTLDL
                     IEKNRVIKNYTEKIDFSKMDYDDPKVYEMLSSGNTLGVFQLESAGMRSFMKQLKPDNF
                     EDIVAGISLFRPGPMDSIPAYIKNKSNPKDVTYLHEKLKPIMEVTYGCLVYQEQVMQV
                     VRDLGGYSYGRSDLVRRAMSKKKMDVMEEERQYFIHGKFDEDGNIEIAGCIRNGVEEE
                     IANKIFDDMIDFARYAFNKSHAAAYGVLAYETAYLKTYYPVEFMAALITSVMGNTDKV
                     VEYIRECKALEIDVLPPDINKSFSKFSVEGDNIRFGLAAVKNVGVNIINNIIAERESN
                     GLFVDLVDLVKRLDQKDTNKRVIESLIKCGAFDNISENRASLMAGYESLLESVSMDRK
                     KNVQGQISLFDAFGDSEEDSDFQQIYSLPKRQEYEERERLNLEKEVLGMYVSGHPLSQ
                     FEKELQEKTSMDNGKLNSLKEEEESYLQMNETDVIMGGMIVTKTIKTTKRNEIMAFIE
                     LEDLYGAIEIIVFPQLLQKYNVILNEDNIIYVKGTLSIKEGENAKLIAREIKDINDDT
                     DFADRNYNSGRTRNVENIKPESGKKLYLKIDSMSDTDTTNNIVEIAKQYPGNDSIYLY
                     PMDENINGKRKAYKMTGALTCICDEFINNLEELLPKDNIKVKA"
     gene            complement(9990..10937)
                     /gene="whiA"
                     /locus_tag="KRO40_002669"
     CDS             complement(9990..10937)
                     /gene="whiA"
                     /locus_tag="KRO40_002669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HBH2093486.1"
                     /translation="MSFSTETKNELARVISGNECCNIAELSALVKSGGSIQIVGYKKL
                     NLKITTELNSIARKVFKLLKKNFNINTTISVNKNQMLKRNNSYVLMVTSEMGSEMLLK
                     KLGILEDKEGFFTINKISENLIKHEGCKRAFIRGAFLGGGSISDPEKNYHMEFVTNNE
                     EFADSLKELINSLGFNSKIVARKNNHVVYIKESEQISDLLSIIGGHHALLSLQNTKIV
                     KEMRNNVNRIVNCETANLSKTVNAAVRQVENIKLIQETIGISSLPENLQEIAKIRIEY
                     EDMTLKELGEMLEPPIGKSGVNHRLRKIEEIATDLKKKS"
     gene            complement(10954..11379)
                     /locus_tag="KRO40_002670"
     CDS             complement(10954..11379)
                     /locus_tag="KRO40_002670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBH2093487.1"
                     /translation="MREEVSAGGVVLFGNTILLLRKFNGDWVLPKGKVEEGENNQEAA
                     LREVSEETGVKADILKYLGEIHYTFKENWDENRAVHKTVFWYLMQAKNMDTIPQKEEG
                     FIDAKFIHLDRVVDLARYDDEKEIIKVALQEIKKRLKKN"
     gene            complement(11448..12554)
                     /locus_tag="KRO40_002671"
     CDS             complement(11448..12554)
                     /locus_tag="KRO40_002671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HBH2093488.1"
                     /translation="MAKLLIIVGILGWIALIVSLFIYKKAKNEKVKLFQRSIVENREP
                     NVVVIGGGTGQSVFLRGLKHTTQNITAIVTVADDGGGSGVLREDLGMLPPGDIRNCLL
                     ALANIEPTMNEVMQYRFTEGLLKGQSFGNLFLAAMNGLYGNFEKAVYKLSEIFAITGR
                     VLPVTLEDVNLVAKLENGNIINGESSIPEESKIQKSSIDKIFLNPKDVKPLKDVIASI
                     YDADIIIMGPGSLYTSIIPNLLVEGIVDAIKSSVAPKVYIANIMTQPGETEGYNVLEH
                     VNAIVKHTDENLIDYVIANNEILPEEMLDLYKQDGAEQVLLDKKQKDKLKEMGIKTVE
                     KNLIEIKNNYIRHDAKYISNIVIELALNHNYNKS"
     gene            complement(12566..13423)
                     /gene="rapZ"
                     /locus_tag="KRO40_002672"
     CDS             complement(12566..13423)
                     /gene="rapZ"
                     /locus_tag="KRO40_002672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HBH2093489.1"
                     /translation="MKFVIVTGLSGSGKSETMRALEDMGFYCVDNLPPALITKFAELC
                     YQPNSSIDKVALGIDIRGRKFFEALHESLNYLEKENYEYEMVYLDCNDDVLLKRYKMT
                     RRNHPLAKDMQIPEGIKMERKIMEPLKELSTCIIDTTNMKPKDLKEEIKKIYSSGEDN
                     PNLTISVVSFGFKHGILADADLVFDVRFLPNPYYVEELRAKTGDDKEVRDYVMNSKIS
                     EEFYVKLLDMIHFLVPQYIEEGKQHLVIGVGCTGGRHRSVTITNLIAEDLSNKGYRVV
                     KKHRDSMLR"
     gene            complement(13454..14167)
                     /locus_tag="KRO40_002673"
     CDS             complement(13454..14167)
                     /locus_tag="KRO40_002673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBH2093490.1"
                     /translation="MKILADYHTHTLYSHGKGTIEDNVKVAISKGIKTIGISDHSYKH
                     IAYGVKKKDILKMREEVDYLNDKYTDINILLGMECNILDDKGNIDMDDKFIRDFDYIM
                     AGYHFGSTPTSLRSLLNHCNNYIFKTEKAKEYNTKAVINAISNNDIFIITHPGDKGDV
                     YIEEVAKTAKKTNTRLEINSSHSFLNVNQLNKIKGLENKFIIGSDAHCPERVGDFELA
                     MKTISDSNLDISLVENIII"
     gene            complement(14171..15085)
                     /gene="murB"
                     /locus_tag="KRO40_002674"
     CDS             complement(14171..15085)
                     /gene="murB"
                     /locus_tag="KRO40_002674"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HBH2093491.1"
                     /translation="MNNQDIYINLLNILSKEDIKVDEPMKKHISFRVGGPADILVRPR
                     TEEQLKNVLKLVKEESIPYLIIGNGSNILIKDGGIRGVVIELADNFNSYEINDTRMTA
                     QSGALLSVLGKALQKQELKGFEFASGIPGTLGGALAMNAGAYGGEMKDIVKSVRLMDM
                     EGNIFELSNEQMEFGYRKSIISKNGYIALSAELELQEGNYDEIKSLMDDLATRRITKQ
                     PLNFASAGSTFKRPTGYFAGKLIEETGLRGLTLRGAQVSEKHCGFVVNQGEASAKDIL
                     DLIYVIKSAVYAKFGVMLEEEVKILGED"
     gene            complement(15358..16128)
                     /locus_tag="KRO40_002675"
     CDS             complement(15358..16128)
                     /locus_tag="KRO40_002675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBH2093492.1"
                     /translation="MSKGFLTPGETAQATISAGIKKANISTQNAILLGLFGGAFIGFG
                     ALGSMIVSQTFGKIDPGVASFLSAMVFPVGLMLVVVAGAELFTGNTLMAIALMDKKIT
                     LGKMLRNWGLVYFANLVGSILLVALVFYSSTLTGDAATKAIAVAEAKVNSTIASMFLK
                     AILCNILVVLAVWMATASQDIMSKLASCWTVIMLFVLCGFQHSVANMFFIPMGMALGA
                     NITMVQFITNLVFVTLGNIVGGSIVVGGIYYLCYVKNS"
BASE COUNT         5030 a         3030 c         1785 g         6379 t
ORIGIN      
        1 atattctttt tgtttttatg aaagtttttt agggggataa taatatatat gtttagagat
       61 aaaatggata gatgtacaca tatgttgact gcttatattg gtagttcata tgattattgt
      121 gattttatag atacacaact agatgatttt atactagagt acggagaaaa tgtggtagaa
      181 tcttgtttgc atcaagtgat ggtattagta agtaagtata attaaataga tttggttttc
      241 tagagaaccc tttttagttt tatctacttt aaatagcctt atgttagaaa gctaattaag
      301 atagatttct agtattcata attttatttt ttatttaaaa tacatataat aaagatgtaa
      361 atttgtatca aataataaat atgagaactt aaattctctt atctatgtga aaataaacat
      421 ctcttaaaat gaaattctgt aaacataaat gattttttag tttgaaggat tagattaaca
      481 aaattataaa tttgcaaata agctatatta aaaaatataa taatttttta tataacttat
      541 tcttttataa cttttaattt taaaagagga gaatgtatat aagagtattc aatgtactag
      601 aaaaaatcaa aagaaatatt agaagaaatg gatattgagt aatcaaagaa aagattttga
      661 tattacaaat gatatgtttc aagaaagcat tcctatcaca acaaaaatta ttcttgaaga
      721 catgccttca aatgatgaat taaatcatgt tttttcaaaa ggttgtgaac gaaaaatgaa
      781 aaagagaaaa attgtattaa tcacactact attaataggt gttttgttat taggaagtat
      841 cctatataat ctttttttag gaaaaacagc taatatttca atgctaaagg aatcttggaa
      901 ttttgatata ccaataccta acaaagaaat tgaagtattt gatactcaag atagtattaa
      961 tggagatgga caaagttatt ttattcaagg attttctgaa aaaaatttca aaaaagtttt
     1021 taatttaaaa ggtggtatag ttgtaagcaa agataatatt aatgaaatag aaaaatatat
     1081 tgataaattt aaaagagatt ctgttaacat taataaaagt aataaaaata aaattgaaga
     1141 agattttaaa aaatataagt tagaagttaa aaaagatgat aagtatatat ataagagaaa
     1201 ttatgagaac tacgtagttt taattataaa aaaagatgaa caaaaattat acagtttaat
     1261 atggaatcag taggtacata tgtattatta agaattataa ataataaaaa taaattttag
     1321 tcaatataca aaaacctttt aaattgtctg gaaatcacct cttcatttgt tataaaaaca
     1381 tacaacaaat gaagaggtga ttttatggtt ttaaaaaaaa taattataag tggatatgtg
     1441 ctttcacatg tttatcaaca tttgtaatgc ctatatttgc taatgaatta taatataaaa
     1501 atattaaata atattcaact atagattatg taaattactc tatgaaaaaa ataagttgta
     1561 taaaatctgg ctactgtaga ttgacgattt cttttaaaat tacaattata ataagtttta
     1621 tagaattaaa aataaaactt tagagatttt tgataacatt gtagactaaa tttgccacca
     1681 aaatcgcttt acagtggcaa atcggtggca aatacaatat attattagta tataatctat
     1741 ataaacatta ctattgtttg attatcttag ctacagtttc cacatgtgta gaatgaggga
     1801 acatatctac aggttgtgcc tcaacacatt taaatccgtg aacatttaga taatctaaat
     1861 cccttgctaa agtagaagga ttacaagaaa catagacaat tctttccgga ttcattgaaa
     1921 caatagtctc taataccttt tcgtcacatc cctttctagg tgggtctaca actactacat
     1981 tggcagtctt accctctcta tacatcttag gtacaatttc ctctgccttt ccaacataaa
     2041 attcagcatt atgtatattg tttaatttag catttatttt agcatctttt atggcatcat
     2101 ctataatttc tattccataa acctttttag ccttttgtgc caaaaataaa gatattgtac
     2161 ctatcccaca gtaaatatca aaaacagtat cagtatcatt taaatttgca tattcaagag
     2221 ccttatcata caatacttta gtttggacag ggtttacttg gaaaaatgat aatggtgaaa
     2281 tctcaaacac taagtcacct atataatcgt ttatttttcc atctccatat ataactatat
     2341 tttctcttcc tagaatagca ttcgtatctt tttgatttac atttacaacc aaagtcttaa
     2401 atccaggtat attttcctta agcactgaag ctaattcttt aagatatgga agtttgtttc
     2461 catttgctac taatacaacc attacttctt tagttgtaaa acctattttt gttactaaat
     2521 gcctaatcaa ccccgtgtga gtcttttcat catatatact taccttatag gcccttatat
     2581 atgtttttat tattttaaca attttatcat ttatctcatg ttgtattacg catttttctg
     2641 tcgatattac atcatgagtc ttctttttat agaagccaat aattggaata ccattattct
     2701 tttgtattgg aaattgtgct ttatttctat atctatatgg attatccatt cctatagtgt
     2761 catgaacttc tacatcctct aacttaccta ttctcgaaag tacttgttta acttcatttg
     2821 ttttcatttc aagttgttta ttataatcta agtcttgtat ctgacaccct ccacaatccc
     2881 taagattgtc actacacact cttttcaccc tgaatggaga cttttctatt atctcaacaa
     2941 tatctcccac agcataattt ttctttactt tattaatcct aactttaact ttatcatgta
     3001 ttaatccgcc ctctacaaaa actgtaatac cattgtactt tcctactcct actccgcctt
     3061 gaccaatgtc tactatatct acaatataca tctcgttttt cgaaagcata aatcaccctc
     3121 caatcaatct attatattta aatctttaca aacttttttc tttaaattta tattaaaata
     3181 ttgctattaa ttaaactata ttttttacta agctacaata ttttatttta ccaaaaaaaa
     3241 aggagcttat aaagcccctt agtaaataaa tttattattt ttcttataaa actctagttg
     3301 aacctctata taccacgcct cttgatgcat ccacagttac aacttctcca tcttttacta
     3361 gatttgttat atcagctgca gacacaataa ctggtatatc taaatttata cctacaatag
     3421 ctgtatgtga tgtcattcca ccattctcag ttactacagc tcctgctttt tctatataat
     3481 tgttcatttc agcatcagta gcagtagaaa caagtatgtc gccttcatta aagtctacac
     3541 aagcatttcc attctttatt atacgaactt taccttctac cgtttgagta cctacaccta
     3601 taccttgcac gatttcttcg cttattacat gaacctttat taaattagta gttccactta
     3661 ctcctactgg tactccagca gttataacta ctaattcccc attatctata taatcagctt
     3721 gtctagctgc ctcaattgcc ttttctataa cttcatctgt atttcctgca acagaagact
     3781 taactggata tactccccat gtaagagcta atttattcat agtcttttca ttatttgtag
     3841 tagctattat tggagatttt ggtctaaatt tagataccat tctagcagta tatcctgaag
     3901 aagtagatgt tattatagct gatgcattta aatctactgc tgttgtacaa gttgcatggc
     3961 ttattgcatc tgttacagta acattgttag taccattttc ctttagtaat ctatcataat
     4021 ctaaagtctc ttctgttctt tttgctattg tagccatcat ttttactgcc tctacaggat
     4081 attttccagc agcagtttct ccagataaca ttatcgcatc tgttccatca tatatagcat
     4141 tggcaacgtc tgtaacttct gctcttgttg gtcttggatt tcttatcata gaatcaagca
     4201 tttgagtggc agtaacaact ggctttgcta attcattaca tttttttatc atcatttttt
     4261 gaactattgg catctcttca gttggtatct caacacctaa gtcacctcta gccaccatta
     4321 taccatcaga aacttttaat atttcatcta ggttctctac accttcttgg ttttctattt
     4381 tagatattat ttgtatatca gttgcattat tgttctctaa tacttctctt attgctagta
     4441 catcagatgc ctttcttaca aaagaagcag ctatataatc tattccttga cttattccaa
     4501 actctatatc acttatatct ttaggagtta ttgctggtaa atttatctta acaccaggta
     4561 catttactcc tttatgattt ttaactattc ctgaattttc aacaacacaa actatatctt
     4621 ctccatttat ttcttttact cttaagccaa ctaaaccatc atctattagt atagaatctc
     4681 ctgatttaac gtcttcagca agacctttat agcttactgt acacatttct ttagtcccca
     4741 taatatcttt catagttata gtgaactttt gcccttcttc taaaaatacc tctgggtctt
     4801 caaagttacc tgttctaatt tctggacctt tagtatctaa taatatagca actggcttat
     4861 ttaatttttc tctaactttc tttgccatat caattctttc tttatgttct tcatgcgaac
     4921 cgtgagaaaa gttaaatcta cacacattta gaccattttg cataagttga gttaaaactt
     4981 cctcactttg tgatgctgga cctagtgtac aaacaatttt tgtcttcttt acattattta
     5041 acatatttgc tcctcctgag atattattcc acagatttat ttttaatact aaaacttata
     5101 tagataatat ttttgccatc tcataagctt ctttatcaaa tactttcttt tgagctaaag
     5161 cttcacttat ttctaaatca attattttgt tttcttttat tcctacaact ctagctgatt
     5221 ttccatctaa taataattct actgctctta ctccaagtct acttgctagt attctatcag
     5281 atacagttgg gcttcctcct ctttggacat gccccaatac agtgactctt aaatctgctc
     5341 ctgactcttt tttaagttcc ttttctaaat cactagcact tccgactcct tctgctaaaa
     5401 cgattatact atgtctctta cctctttttt gagtagtctt taatcttaga gcaacttcat
     5461 ctactgtaat ttctacttct ggtactatta tagtttccgc tcctcctgca agacctgcat
     5521 ataaggctaa atctccacag tgtcttccca taacttctac tatgttaact ctttcatgag
     5581 atgatgatgt atctcttatc ttacctatag catctataat agtattcatt gcagtatcaa
     5641 atcctatagt ataatctgta tatgctaaat cgttatctat agttcctggt atgcctatag
     5701 ctgggaatcc taagtcacta agtttttggg ctcctgcaaa tgaaccatct ccaccaatta
     5761 caactaagca atcaatttta tactttttaa gaatttttac tgcttttaat ctaccttctt
     5821 ctgttttaaa ttcttcacat ctggaagatt ttaatatagt tcctcccctg tgtataatat
     5881 ctccaacaga agataagttc atttcagtta aatcttcttc tagtaatccc ttatatcctc
     5941 tattgattcc atatactttg catccataat atattgctga tcttacaacc gctctaatcg
     6001 cagcattcat tcctggagca tctcctccac ttgttagtaa tcctatagtt ttcatttttt
     6061 acctccttgg attttatgtc aattttttat tataatcatt gttattgtat tctaatggac
     6121 tttttttgtc cctatatcac tttttaatcc catcaagact aaaaaaatta aatgtcctta
     6181 aatgtccatt ttgtgatatt atatcacaaa acggacaata tttttcatat tattataata
     6241 tatttagatt tttatataaa aaatcaagct tttactttta tgttatcttt aggaagtaac
     6301 tcttctaagt tatttataaa ttcatcacat atacaagtca atgccccggt cattttatat
     6361 gctttacgtt taccatttat attttcatcc atagggtaca agtatatact gtcattacct
     6421 ggatattgtt tggctatttc tacaatatta ttagttgtat cagtatcaga catactatct
     6481 attttcaaat acaatttttt accactttct ggcttaatat tttctacatt tctagttctt
     6541 cctgaattgt agtttctatc tgcaaagtca gtatcatcat ttatatcttt tatctctcta
     6601 gctataagtt ttgcattttc gccttctttt atacttaatg ttccttttac atatattata
     6661 ttatcttcat tcaaaatgac attatacttt tgtaataatt gaggaaaaac tattatttct
     6721 atagcaccat acaaatcttc taattcaata aatgccataa tttcatttcg ttttgttgtt
     6781 ttaatagttt tagttacaat cattccaccc attataacat ctgtttcatt catttgtagg
     6841 tatgactctt cttcctcttt taatgaattt aattttccat tatccataga tgttttttct
     6901 tgtagttctt tttcaaattg tgataaagga tgtccactta catacattcc caagacttct
     6961 ttttcaaggt taagtctctc tctttcttcg tactcttgcc ttttaggcaa actgtatatt
     7021 tgttgaaaat cactatcttc ctcactatct ccaaaagcat caaataaaga aatttgacct
     7081 tgaacatttt tctttctatc catagataca ctttctaata aactttcata accagccatc
     7141 agactagctc tattttcact tatattatca aaagctccac attttattag actttctatt
     7201 actctcttat ttgtatcttt ttggtctaat cttttgacta aatctactaa atctacaaat
     7261 aatccattag attctctttc agcgattata ttgtttatta tatttacgcc aacatttttt
     7321 acggctgcta gaccaaatct tatattgtcg ccttcaactg aaaactttga aaaacttttg
     7381 tttatatctg gaggtaatac atctatttct agtgctttac attctcttat atactcaact
     7441 accttatcag tatttcccat tacactggtt atcaatgctg ccataaattc aactggataa
     7501 tatgttttta gataagctgt ctcatatgct aaaaccccat atgcagctgc atgtgattta
     7561 ttaaatgcat atctagcgaa gtctatcata tcatcaaata ttttattagc tatttcctct
     7621 tctacaccat ttctgataca ccctgcaatt tctatattac catcttcatc aaatttacca
     7681 tgaataaaat attgtctttc ttcttccatc acgtccatct ttttcttact catggctctt
     7741 ctaactaggt cacttcgtcc gtaactataa ccacctaaat ctctaacgac ctgcataacc
     7801 tgctcttgat ataccaaaca accatatgta acttccatta taggctttaa tttttcatgt
     7861 agatatgtta catcttttgg gttgctttta ttttttatat atgcaggtat agaatccatt
     7921 ggacctggtc taaataggga tattcccgct acaatatctt caaaattgtc tggttttagc
     7981 tgtttcataa aacttctcat gccagcactc tccaattgaa acacccctag tgtatttcct
     8041 gatgaaagca tttcatatac tttagggtcg tcataatcca tctttgaaaa gtctattttt
     8101 tctgtgtagt tttttataac tctatttttt tctattaaat caagagtatc tcttataact
     8161 gtaagagttc ttagcccaag aaaatccatc tttaaaagcc caagttcttc aagtgttgtc
     8221 atagtaaact gtgttgtgat tgcatcttga tgtttgtaca aaggtacata ttcatctacg
     8281 ggattttttg atataacaac tcctgctgca tgagtagaag catgtcttag cattccctct
     8341 atctgttttg atatatttat tatttctttt gtttccgggt cttggtcata caattcttta
     8401 agattaggat ttgtatctag ggccttatct attgtcattc ctaaagcaaa tggtatttcc
     8461 ttggctacct tgtcaacttt attgtagcct atatccaata cccttccaac atctcttatt
     8521 gcagcttttg cacccattgt tccaaaagtt attatctggg ctacatggtc atcaccatat
     8581 tttctcttta cataatctat aacttcttct cttctctcat aacaaaaatc tatatctata
     8641 tctggcatgg atatacgttc tggatttaaa aaacgctcaa ataatagaga gtactttatt
     8701 gggtctatat cagttatttt aagtgtatat gctactatcg aaccagccgc actacctcta
     8761 cctggtccta ctataatatt attttcttta gaaaaattta taaaatccca aacaattaaa
     8821 aaatattcta cataacccat tttttcaatt acatctaatt cataatttaa tctctctagt
     8881 atctcattgc taggattatc atatctctct tttaatccat taaaacacaa ctcccttaaa
     8941 taagtttctg gtgtatatcc ttctggaaca tcatacttag gaagatgtat agtgttaaaa
     9001 tcaaactcca cattacacat atcagctatt ttcacagtat tatcaatagc ctctaatgca
     9061 tatggaaata attcttccat ttcttctctt gattttaaat aaaactcatc actaccaaat
     9121 ctcattctat ttgggtcatt taatgttttt cccatttgaa tacacataag tacatcatgt
     9181 attttcgaat cttctttatt tacatagtga acatcattag tagcaactag tggtatacca
     9241 gtctcttttg ataattttac taaaccagag tttacttctt tttgctcagg taaattgtga
     9301 tcttgaatct ccaaaaagaa attttcttct ccaaatatgt ctctatagtc aagagcaaat
     9361 tgttttgctt tttcataatt tctattcatt aaagcacgtg ctacatctcc tgcaaggcat
     9421 gcagaaagtg ctataatccc tttgttatgc tttttaagtt cttccatgtc aactctaggc
     9481 ttatagtaaa aaccttctac gtatgaagtt gaaactattt ttattaaatt tttatatcct
     9541 tccatattct tagctaacag aactaaatgt ccttgatatt tgtcatagtt tgggtcttta
     9601 tctctcaatc cacgtgcagc tgtatagact tcgcacccta taattggctt tattccttct
     9661 tttatagctg ttttgtagaa atctataaca ccaaacatac aaccatggtc agttatagct
     9721 attgagctca tgtttagttc cttagccctt tttataagtt ttttcaccct cgaaaaccca
     9781 tcaagtaaac tatactcagt atgtacatga agatgagcaa aatctttgtt cattaaatca
     9841 cctcctgctt tataatttta attttaccac aaatatatgt actaaaacaa aaacagagac
     9901 ttttatctca aaataggaat taacttcaac gtataccatt atatgttata aattaatgct
     9961 tattctgaga ttgtcccctc aatttattgc tatgattttt ttttcaaatc tgttgcaatt
    10021 tcttctattt ttctaagtct atgattgact ccagattttc ctattggtgg ttctaacatc
    10081 tctccaagtt ctttgagagt catatcctca tactcgattc taatcttagc tatctcttgt
    10141 aaattttctg gcaaactgct aattcctata gtctcttgta tgagcttaat attttctact
    10201 tgtcttactg ctgcatttac tgttttagaa aggttagctg tctcacaatt tactatcctg
    10261 tttacattat ttctcatttc ttttactatt ttagtatttt gaagacttaa aagagcatgg
    10321 tgtcctccta taatactcaa caaatctgat atttgttcac tctctttgat ataaacaacg
    10381 tgattatttt ttctagccac aattttacta ttaaaaccta aagagtttat aagttctttt
    10441 agagaatctg caaactcctc attattagtt acaaattcca tatgatagtt cttttctggg
    10501 tcacttatag aacctccacc aagaaaagct cctcttatga aagctctctt acatccttca
    10561 tgcttaatta agttctctga aattttgttt atagtaaaaa atccttcttt atcttcaagt
    10621 atacctaact tttttaataa catttctgaa cccatttcgc ttgttaccat taatacataa
    10681 ctgttatttc tctttagcat ttgattctta tttactgaga ttgtagtatt gatattaaaa
    10741 ttctttttta ataatttaaa tactttacgg gctattgaat ttaactctgt tgttatcttt
    10801 agatttagct tcttatatcc aacaatttgt atacttcccc ctgatttaac tagagctgac
    10861 aattcagcta tattacaaca ttcattccca gatataactc ttgctagttc atttttggtt
    10921 tcagttgaaa aagacatatc tatcacctat taactaattt ttctttaacc ttttttttat
    10981 ttcttgtaag gcaaccttta ttatctcctt ttcatcatca tacctagcta agtctactac
    11041 tctatctagg tggataaatt tagcatcaat aaagccttcc tctttttgtg gaatagtatc
    11101 catattcttt gcttgcatca aataccaaaa aactgtttta tgaactgctc tattttcatc
    11161 ccagttttct ttgaatgtat agtgtatttc acctaaatat ttcaatatat ctgcttttac
    11221 tccagtttct tcacttactt cacgtaatgc tgcctcttgg ttattttccc cttcttctac
    11281 ttttcccttg ggtaacaccc aatctccatt gaacttcctt agtaaaagaa tcgtattgcc
    11341 aaacaggact acaccaccag cactaacctc ttctctcatc gatgttcact ccttaaaact
    11401 aacataatga taaggatttc tacacaattt tttaaaatcc ttttttacta acttttgttg
    11461 taattatgat ttagggctaa ctcaataact atgttagata tatactttgc atcatgtctt
    11521 atataattat tttttatttc aattaaattc ttctctacag tttttatacc catctctttt
    11581 aatttatctt tttgcttttt atctaacaag acttgctctg ctccatcttg tttatataag
    11641 tcaagcattt cttctggcaa tatctcatta tttgcgatta cataatctat taaattctca
    11701 tcagtgtgtt ttactatagc attaacatgc tctaatacat tatacccttc tgtctcacct
    11761 ggttgagtca ttatatttgc tatatatact tttggagcta cagacgattt aatagcgtct
    11821 acaatcccct ctacaagtaa attgggtatt atacttgtat ataaacttcc aggacccata
    11881 attataatgt cagcatcata aatagatgca ataacatcct ttaatggttt tacatctttt
    11941 ggatttaaaa aaattttatc aatagagctt ttttgaattt ttgactcttc aggtatacta
    12001 gattctccat ttattatatt gccattttct aatttggcaa ctaaatttac atcttccaaa
    12061 gttactggta aaactcttcc tgttatagca aaaatttcac ttaatttata tacagctttt
    12121 tcaaagtttc catacaaccc attcatagca gccaaaaaca aatttccaaa actctgacct
    12181 tttaaaagcc cttctgtaaa cctatattgc ataacttcat tcattgttgg ctctatattt
    12241 gcaagtgcta ataaacagtt tcttatgtct cctggtggga gcattcctaa gtcttctctc
    12301 aatacacctg aacctccacc atcatcagca acagttacaa ttgcagttat attttgcgta
    12361 gtgtgtttaa gacctcttaa aaataccgat tgaccagtac ctccacctat cacaaccaca
    12421 tttggttctc tattttcaac aatagacctt tgaaatagtt ttactttttc attttttgct
    12481 tttttatata taaataacga tacaattaat gcaatccaac ctaaaattcc tacaataata
    12541 agtaatttag ccatgtttgc ctccattatc gcaacataga gtctctatgt ttctttacaa
    12601 ctctatatcc cttattagat aaatcctccg ctataagatt tgttatagta actgacctat
    12661 gtcttccacc tgtgcatcca acaccaatta ctagatgttg ttttccttcc tctatatatt
    12721 gaggtactaa aaaatgaatc atatctaaaa gtttcacata aaattcttca ctgattttag
    12781 aattcataac ataatctcta acttctttat catcaccagt tttagctctt aactcttcaa
    12841 cataataggg atttggaaga aatcttacat caaatactaa atctgcatca gcaagtatac
    12901 catgtttaaa tccaaaagat actacagaaa tagttaggtt tggattatct tcaccagaag
    12961 aatatatttt ctttatttct tccttaaggt ctttaggttt catgttagtt gtatcaatta
    13021 tacatgtaga taactccttt aaaggttcca ttatctttct ttccattttt ataccttctg
    13081 gaatctgcat atcttttgcc aatggatgat ttcttcttgt cattttatat ctctttaaca
    13141 atacatcatc attacaatcc aaatatacca tttcatattc ataattttct ttttctaaat
    13201 aatttaagct ttcatgaagc gcttcaaaaa actttctccc tcttatatct atccctagag
    13261 caactttatc aatacttgaa tttggttgat aacataattc tgcaaattta gttatcaaag
    13321 caggaggtag attatctaca caataaaatc ccatatcctc taaagctctc attgtctcac
    13381 tttttccaga tcctgaaaga cctgtaacta taacaaattt cattgctaac tcctcccttt
    13441 tatcttatgt ttattatatt ataatgtttt ctactaacga tatatccaga ttagagtcag
    13501 atatagtctt catagctagt tcaaaatcac caactctttc tggacaatgt gcatctgagc
    13561 ctattataaa tttattttct agccctttta ttttatttaa ttgatttaca ttcaaaaaag
    13621 aatggctact atttatctca agtctagtat ttgtcttttt tgctgtcttt gctacttctt
    13681 ctatatacac atcgccttta tctcctggat gagtaattat aaaaatatca ttattactta
    13741 tcgcatttat tacagctttt gtattatatt cttttgcttt ttcagtttta aaaatatagt
    13801 tattacaatg atttaataag cttcttaatg atgttggagt agaaccaaaa tgatatccag
    13861 ccataatata atcaaaatct ctaataaatt tatcatccat atctatattt cctttatcat
    13921 ctaatatgtt acactccata cctaaaagta tatttatatc agtgtactta tcatttaaat
    13981 aatctacttc ttctctcatt ttgagaatat cttttttctt tacaccatat gcaatatgtt
    14041 tataactatg gtcagatatt cctattgttt ttattccttt agaaatggct acctttacat
    14101 tatcctcaat agtccctttg ccatgactat ataatgtatg tgtatgataa tcagccagta
    14161 ttttcatttg ttaatcctct ccaagtattt tgacttcttc ttccaacata accccaaact
    14221 tggcatatac agcacttttt ataacatata ttaaatccaa aatatcttta gcacttgctt
    14281 ctccttgatt gactacaaat ccacaatgct tctcagatac ttgtgctcct cttaaagtaa
    14341 gacctctcaa tccagtttct tctattaatt tacctgcaaa atatcctgtt ggtctcttaa
    14401 atgtacttcc tgcactagca aaatttaatg gttgtttagt tattcttctc gtcgctaaat
    14461 catccattaa actttttatt tcatcataat ttccttcttg taattctaat tctgctgata
    14521 aagctatata tccgtttttc gatattatac tttttctata cccaaattcc atctgttcat
    14581 ttgataattc aaatatattg ccttccatat ccatcagtct tactgacttc actatgtcct
    14641 tcatttcacc accatatgct ccagcattca tggctaatgc tcctcccaat gtgccaggta
    14701 ttcctgatgc aaactcaaac ccttttaatt cttgcttttg gagagctttc cctaaaactg
    14761 ataataaagc tcctgactga gcagtcatcc tagtatcatt tatctcataa gaattgaaat
    14821 tatcagctag ttctattacc actcctctta ttccaccatc tttaattaaa atgtttgaac
    14881 catttccaat tattaaatac ggaatagatt cttcttttac caacttaagt acatttttta
    14941 attgttcttc agttctaggt ctaactaata tatctgctgg tcctcctacc ctaaatgaaa
    15001 tatgtttttt cataggttca tcgactttta tatcctcttt acttaatata tttaataaat
    15061 ttatatatat atcttgatta ttcattgtat ttcctcccaa attatactga actttagctg
    15121 tcattattat ttaaattaca ttagtatata gtattaacta tattcaataa tatatgattt
    15181 tgcttatcat atggatttta tattttaagc ttcttaatta caaactatat tcaataaata
    15241 tataataaag taaaaaaaaa aaaataacaa catataaaag aatataaata atttaaaaaa
    15301 agcatcaata tcactgatat caatgcttta aaaggcaatt taattcgtat tatttatcta
    15361 actatttttg acatagcaaa gataataaat ccctccaact actatggaac ctccaacgat
    15421 atttccaagt gttacaaata ccaaattagt tataaattga accatagtta tatttgctcc
    15481 taatgccatt cccattggta taaaaaacat gtttgcaaca ctatgttgga atccacataa
    15541 tacaaatagc attattactg tccaacatga agccaatttt gacattatat cttgagatgc
    15601 tgtagccatc catacagcta aaacgactag aatattacaa agtattgctt ttaaaaacat
    15661 tgatgctata gttgaattaa ccttagcttc tgccacagct atagcttttg tagctgcatc
    15721 tcctgtcaat gtagaagaat aaaacacaag tgcaactagc aaaattgaac ctactaaatt
    15781 tgcaaaataa accagtcccc agtttcttaa catttttcct aatgttattt ttttgtccat
    15841 aagtgcaata gccattaagg tgtttccagt gaataattct gctcctgcca ctactacaag
    15901 cataagacct actggaaaga ccatagcact taaaaagcta gctacccctg ggtctatctt
    15961 gccaaaagtt tgactaacta tcatactccc caatgcccca aaacctataa atgctcctcc
    16021 aaataaacct aatagaattg cgttttgtgt cgaaatattt gcttttttaa tgcctgcact
    16081 tatagttgct tgtgcagttt ccccaggtgt caagaatcct ttactcataa atccttcccc
    16141 cttaaaaatt atactttccc ttgtcttttt atggcaataa ttatataata acaatatgat
    16201 atataataaa ttttattaac ataa
//
LOCUS       DAEQCW010000084        15916 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.085, whole genome shotgun sequence.
ACCESSION   DAEQCW010000084 DAEQCW010000000
VERSION     DAEQCW010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15916)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15916)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15916
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.085"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(99..833)
                     /locus_tag="KRO40_002676"
     CDS             complement(99..833)
                     /locus_tag="KRO40_002676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBH2093493.1"
                     /translation="MSIQKLLSKARKAIQDFDMIQENDKIAVGLSGGKDSLTLLHILK
                     SYQRFSPQNFELIAITLNTGGVDNSPLDKLCKEINVPFYEFQTDIKEIVFDIRQEKNP
                     CALCANLRRGALNDNAKKLGCNKVALGHHKDDAIETFLMSMFYEGRVNCFSPKTYLDR
                     QDLTVIRPMVYIEEYMTKKISKDSNYPIITNPCPANGHTRREYIKNLIANLNKEMPDF
                     KRNVFGALNNSEKLFIWDKEKIKNFK"
     gene            958..1674
                     /locus_tag="KRO40_002677"
     CDS             958..1674
                     /locus_tag="KRO40_002677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH2093494.1"
                     /translation="MKKFKLIGAIILVVFISVFISKDRLLKKDKDPIVAAQHDSEQDV
                     EANSQNKNHSNSISNILLVNKTNGISKNYTPENITKVNIPFVEEATEEEKQMAGEPAK
                     AVEDLVKQANSEGIQFLGSSAYRSYDTQLDTYTRRVKSQGREKADAYVAKPGYSEHQT
                     GLCIDLTNPERWFVGSTKEAKWLAENAHKFGFIIRYPEGKEDITGTAYEPWHIRYVGK
                     DAAEEIYSKGLTLEEYLQNK"
     gene            1808..2500
                     /locus_tag="KRO40_002678"
     CDS             1808..2500
                     /locus_tag="KRO40_002678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093495.1"
                     /translation="MNNTVLVVDDEKEIRDLIEIYLLNSGYNVIKAEDGKEALDILKK
                     ENIHLMILDIMMPKMDGIEVCRKVRESLNIPILMLSAKSEDMDKIQGIMTGADDYLTK
                     PFNPLELTVRVKSLIRRAYYFSGANNEDKDVIKVGVVIIDKEKHSVTVAGNEIILTSR
                     EFDILYLLANNKGRVYSTEEIFEKVWKEKYYQSNNTVMVHMSRIRDKIEKYTDGEKII
                     HTVWGVGYKIEK"
     gene            2490..3671
                     /locus_tag="KRO40_002679"
     CDS             2490..3671
                     /locus_tag="KRO40_002679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2093496.1"
                     /translation="MKNKSLLNHMFRPILDLIISCALTSMLILTSMYIIKSLYVNSDM
                     SVVNQLVYQARDFRSLIGYDLFYPFLFTITSLAIYSMISYKRNKQIVDFIRKTNRKNQ
                     KLEIIKSAVNLMDEGNLEKSIDIEYDLDILKDKEKDDIDELAHKINNIVHQLRNITIE
                     ERQAQQTKTDLITNVSHDLRTPLTSIMGYLGVIEEGKYKDEVQMMYYVDIAYEKSKNL
                     NVLINDLFELTKMQNNTIKLNKIEINLVELLSQVVSQFEIYFKQEFMVSRINFNEEKL
                     IVKADPNKLVRAFENLITNAVKYGKDGHYVDIVTEKKEDMAVVKVINYGEPIPVLDLP
                     NIFDRFYRVEKSRNRNVGGSGLGLAITKNIVNLHDGEITVSSDKYQTVFEVQLPIIQS
                     A"
     gene            3953..4408
                     /locus_tag="KRO40_002680"
     CDS             3953..4408
                     /locus_tag="KRO40_002680"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HBH2093497.1"
                     /translation="MEKVESFKLDHTKVKAPFVRKCSVLDGVKGDKVTKFDLRFLQPN
                     VESFGTAAMHGLEHLLATYLRDTLDGVIDLSPMGCRTGFYLILWGDVDAKTVKIGLEE
                     ALKKVLESDKMPAATAIECGNYRDLSLFGAKEYAKDVLDKGFSLNIYGE"
     gene            4398..5123
                     /locus_tag="KRO40_002681"
     CDS             4398..5123
                     /locus_tag="KRO40_002681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Vitamin B12 dependent methionine synthase,
                     activation domain protein"
                     /protein_id="HBH2093498.1"
                     /translation="MENNLIGREDISINQSEVLRYLQYRGQEIDKDLKYTIDECVAIT
                     KNKINPRYLSRIYPIKINKDNVVELEGTNLTLESKDVYELLKECNECVIMAATIGIDI
                     EKEIRRHSYSNLTKGLIIDSCGTTAIEEVCDIVQNNLEKVFLKQDKFITMRYSPGYGD
                     LPIEKNIDILNVLNAQKQIGLTITSNGIMIPRKSVVAIIGISNTRINKSKKEKSCENC
                     KNYRNCTYRKGANSCGNKTISEK"
     gene            5095..7476
                     /locus_tag="KRO40_002682"
     CDS             5095..7476
                     /locus_tag="KRO40_002682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocysteine S-methyltransferase family protein"
                     /protein_id="HBH2093499.1"
                     /translation="MEIRQYLKNNILIFDGAMGTMLQQKGLKLGENPEVFGLQNPDKL
                     IEIHTAYLEAGSNVILTNTFGCNELKLDSKYTVEEVIDNAVLVARKAIENVDNTKPRY
                     VALDIGPIGEMLEPMGTLSFDKAYEIFKRQVLQGVKSGVDVIVIETMMDLYEAKVAVL
                     AAKENSDLPIFCTMTFDEGGRSFTGCMPECMVATIEGLGVDAIGVNCSLGPKQLLPIV
                     EKIASRATVPVMVQANAGLPNIVDGEAIYDVDAKEFFEGVKKFVEVGATIIGGCCGTN
                     PSFIKEISENINSVTKGCIEKIDKCVVCSPSKFVEVQSPTVVGERLNPTGRKSLQEAL
                     KNENVDYAINLGLEQVNAGAQILGVNVGLPEIDEKKLMPKLIREIQAVVDTPLQVDSS
                     NVEALEQGLRYYNGRTIVNSVNGKEESLESILPIVKKYGSCVVGLTLDEKGIPKKAEE
                     RFEIAKRIVNRAVSYGIKPKDIFIDCLSLTVSAQQEEAIETIKAITMVKTLGVKTILG
                     VSNISFGLPNRKALNASFLTLALGAGLDLAIINPNEYSMMEAINSFKILNNTDKGCIN
                     YINQYSNINNSKKSDSSTKIDKDLPLDILVERGLKDEAKNVTLNLLKEKDENYILDEI
                     LIPALDKVGKRYDSGDIFLPQLIQSAETVKVSLNTIKETLLSKSSNNVSKGKIIVATV
                     KGDIHDIGKNIVKIMLENYGYEVIDLGKDVPIEEVVEVAKKRNIKLVGLSALMTTTVQ
                     SMKDTIQALRDNEINAKVFVGGAVLTEEYAEEMGADYYSKDAKSAVEIAKLNF"
     gene            complement(7681..8910)
                     /locus_tag="KRO40_002683"
     CDS             complement(7681..8910)
                     /locus_tag="KRO40_002683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBH2093500.1"
                     /translation="MNLNRNLEKYAELAIKVGVNIQPGQILLIKSPIECADFARNALK
                     EAYKCGAKNVYIEWSDEESTLIKYLYAPDEAFHEFPKWTAEQYVDIAKEGGAFLSVYA
                     QNPDLLKDVDPERVANFQKASGKALKEWRSYTLTDKCKWSIVSVPTKDWAKKVFPNLS
                     EDKAIEKLWDAIFKCSRVDGQDPIKAWEEHNENLKSKMDFLNKNNFKTLKYKSSKTDL
                     TLDLPKGHVWLSGASKDPNGISFNPNIPTEEIFGMPHKFKVNGTVYSTKPLVYGGNII
                     DNFFLTFKDGKIIDFSAEKGLDTLEKLIETDEGSHYLGEVALVPYNSPISNTDIIFYN
                     TLYDENASCHFAIGSAYKTCLEGGNNLKDEELDEHGVNDSLTHVDFMIGSADMDIIGE
                     TYDGKQIQIFKNGNWAF"
     gene            9511..10425
                     /locus_tag="KRO40_002684"
     CDS             9511..10425
                     /locus_tag="KRO40_002684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093501.1"
                     /translation="MELYEAIFYRKSVRNFSSKKIKKPLMEEIKRSCKNLEYLNEDLN
                     IKAHVVDRGHIIHFLMGKECKVKAPHYIVVTSDKGEDYLQNIGFATEGVVLRLTTLGI
                     ATCWLEGNLKREDILEFVDIGNKNFEEDEEDDLDYLAGIKTEEDDENKIENPYIIIAF
                     GYPAKNEELFRTRYARPDRKPVKDMINKINRNRKWKDILELTRRAPSVKNSQPWYFHK
                     DERGLHLFEKRPKKHCEDMNKVSLGVALRHFDIACIKNKIDVSYEKLPIRNKIGKSYF
                     ITVVEHVKPEEETQEENVTLEKEESQDE"
     gene            10449..11084
                     /locus_tag="KRO40_002685"
     CDS             10449..11084
                     /locus_tag="KRO40_002685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1847 domain-containing protein"
                     /protein_id="HBH2093502.1"
                     /translation="MYKCGKCNLRGCSNGNMDKLMKICPTREIELQQKAKQLYEEEEN
                     RKIAYNAGLVEAEGYCQYTRLKEIIEFAKKCGYKKIGIAFCIGLKREMQTVQKIFEHH
                     GFEVFSVICKNGAMPKSTIGLEASQTISKCSDEVMCNPIGQALFLNEAKVDLNVILGL
                     CVGHDTLAMKYMEAPITTLVVKDRVTGHNPVAAIYNAESYFEKKLFDKDEE"
     gene            11460..12176
                     /gene="pyrF"
                     /locus_tag="KRO40_002686"
     CDS             11460..12176
                     /gene="pyrF"
                     /locus_tag="KRO40_002686"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HBH2093503.1"
                     /translation="MINGKEKLIVAIDTDEFDKAKELIDRLEDSVDIFKVGLEQYVAT
                     KGKTIDYLKEKGKKIFLDLKFHDIPNTMKSAVKAAVRDNVWLMTIHVSDMEGMRQCAL
                     IAREEAERLNIEKPLVVGVTVLTSLSNQDLQDIGCNMTTEELAIKRAKLAKESGIDGV
                     VCSAQEVDKIVEACGTDFITVCPGIRPKSAEVGDQKRVVTPSDAIKKGAHYLVVGRPI
                     TKAENPRESAINIVREIENA"
     gene            12202..13245
                     /gene="carA"
                     /locus_tag="KRO40_002687"
     CDS             12202..13245
                     /gene="carA"
                     /locus_tag="KRO40_002687"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBH2093504.1"
                     /translation="MKGKLILEDGTVFEGKAFGYLKEAIGEVVFNTSMAGYGELLTDA
                     TYYGQIVTMTYPLIGNYGINLEDVESNKVQVKGLIVREKSDNPNNFRCEMDIDTYLKQ
                     NKVIGLEGIDTRALTKIIRNNGTKRGIITLENVSLQDVQSKLEEHCNKDSVKNVTRKE
                     IENIKGTGAKVVVIDFGVKNSVLESLKACNCDITIVPAMTTVEEILNINPDLILLSNG
                     PGNPEDINDIVENIKKLIGKKPLTGIGLGHQILALALGGKTSKLVFGHRGGNHPVKCL
                     ETGKVFITSQNHGYNVSEMPENTEVTHINLNDNTIEGMRHKELPIYSVQYIPEYTTKE
                     DLDCIFNKFLALI"
     gene            13298..>15916
                     /gene="carB"
                     /locus_tag="KRO40_002688"
     CDS             13298..>15916
                     /gene="carB"
                     /locus_tag="KRO40_002688"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBH2093505.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQSLKEEGIEV
                     VLINSNPATIMTDKEVADKIYIEPLTIEFIEKIIEKERPDSLLAGMGGQTGLNLAVEL
                     YEKGILDKYGVKIIGTSVESIKKGEDRDIFREVMKEINQPVIVSDIVTDLQAGLDYAL
                     TIGYPVVVRPAYTLGGTGGGIADNEEELREILSHGLQLSPVGQVLIEKSIKGWKEIEY
                     EVIRDSKGNCIVVCNMENIDPVGVHTGDSIVVAPTQTLSNKECAMLKKASLDILNAVE
                     VQGGCNVQFALNPHSFEYAVIEINPRVSRSSALASKATGYPIAKVSSKIALGYTLDEI
                     ENAVTKKTYACFEPTIDYVVAKIPKWPFDKFKKANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHTPSEERSIEELKKRVVVPDDERLFDLAEMIRRGYKVEMIEQ
                     ITGIDKWFINKFKWIVEQEEKLKVMKIEDLTKDYLLELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIKPAYKMVDTCAGEIDAISPYYYSTYEQYDEVVVSDKKKVIVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMDIETIIINNNPETVSTDFDTSDKLYFEPLTEEEVLSI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFDDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWSLNEGIEVANELGYPVLVRPSYVLGGQGMEITYNEEKLSQYLQDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGY"
BASE COUNT         6412 a         1756 c         2866 g         4882 t
ORIGIN      
        1 aataacatat aataaataaa aaagtaagat tgtgtagatt atataaagat tatttacaat
       61 taatacaatc ttgctttttt atttaaaaat tttaattatt atttaaaatt ttttatcttc
      121 tctttatccc atataaacaa tttctcagaa ttatttaaag caccaaatac atttctttta
      181 aaatcaggca tctctttatt taaattagca ataagatttt ttatgtactc tctcctagta
      241 tgaccatttg cagggcaggg atttgtgata ataggatagt tagaatcttt tgaaattttc
      301 ttagtcatat actcttctat gtaaaccata ggtcttataa ctgttaaatc ctgtctgtct
      361 aggtatgtct ttggggaaaa acaatttact ctaccctcat aaaacataga cattaaaaat
      421 gtctcaattg catcatcttt atgatgacca agagctactt tattacatcc aagtttttta
      481 gcattatcgt tcaaagcacc tcttcttaaa ttagcacata atgcacaagg attcttttct
      541 tgtcttatat caaatacaat ttcttttatg tcagtttgaa attcataaaa aggaacattt
      601 atttctttac acaatttatc tagtggagaa ttatcaacac ctccagtatt taatgttatg
      661 gctatcaatt caaagttttg tggagaaaat ctttgataac ttttaagtat atgaagtaaa
      721 gttaaactat cttttccacc agaaagtcca accgcaattt tatcattttc ttgtatcata
      781 tcaaaatctt gtatagcctt acgagcttta cttagaagtt tttgtataga cattttatca
      841 ccatccttta aaaatattaa atttaagatt tatttaagat ttacttataa aatacttaag
      901 tcttatactc taaaattaac attatagcaa acataacaaa aaggagaaga tttaattatg
      961 aaaaaattta aattaatagg agccattatt ttagtagtat ttataagtgt atttatatct
     1021 aaagatagat tacttaagaa agataaagat ccaatagtag ctgctcaaca tgattcagaa
     1081 caagatgttg aggcaaattc tcaaaataaa aatcactcaa atagtatatc aaatatatta
     1141 ttggtaaaca agacaaatgg aattagcaaa aactatactc ctgaaaatat tactaaggta
     1201 aacatacctt ttgttgaaga agcaacagag gaagaaaaac aaatggcagg agaacctgca
     1261 aaggcagttg aagatttagt taagcaagct aattcagaag gaatacagtt tttagggtct
     1321 tcagcataca gatcttatga tactcaactg gatacttata caagaagggt aaaatctcag
     1381 ggacgagaaa aggcagatgc atatgtagca aagcctggtt acagtgagca ccaaactgga
     1441 ctttgtattg atttaacaaa tccagaaaga tggtttgttg gaagtacaaa agaagctaaa
     1501 tggttggcag aaaatgctca caagtttgga tttataataa gatatcctga aggtaaagaa
     1561 gatataacag gtacagcata tgaaccatgg catattagat atgttggtaa ggatgctgcc
     1621 gaggaaattt attcaaaagg attaacttta gaagaatatt tacaaaataa ataatataaa
     1681 tgtgtaaata atttgtatta tattggaaat ttagaaatta ataaatttat agattacact
     1741 aactaaaata tagtataatt ttatatgaat aaagctatat acaaagatta agttaggatg
     1801 tgtaaaaatg aataatacag ttcttgttgt ggatgatgaa aaggaaataa gagaccttat
     1861 agagatatat cttttaaata gtggatataa tgtaattaaa gctgaagatg gaaaagaggc
     1921 tctagatatt ttaaaaaagg aaaatattca tttaatgata ttggatataa tgatgcctaa
     1981 aatggatggg atagaagttt gtagaaaagt tagagaaagt ttgaatatac caatacttat
     2041 gttaagtgca aaatcagaag acatggataa aatacaaggg ataatgactg gtgcagatga
     2101 ctatttgaca aaaccattta acccacttga acttactgtg agagtgaagt cgctgattag
     2161 aagagcatat tattttagtg gtgctaataa tgaagataaa gatgtcataa aggttggagt
     2221 agtaattata gataaggaaa aacatagtgt aacagtggct ggaaatgaaa taattttgac
     2281 atcaagagaa tttgatatat tatatttatt agcaaataat aaaggcagag tatatagtac
     2341 agaagaaata tttgaaaagg tatggaaaga gaaatattac caatctaata atactgtaat
     2401 ggttcatatg agcagaataa gggataaaat tgaaaaatat acagatggag aaaaaataat
     2461 tcatactgta tggggagtag gatataaaat tgaaaaataa aagtttatta aatcatatgt
     2521 ttcgacccat attagatctt ataataagct gtgctttaac ttcaatgctt attttaacaa
     2581 gtatgtatat aataaaatca ttatatgtca atagtgatat gtctgtagtt aatcaacttg
     2641 tatatcaagc aagagatttc agaagtctta tagggtatga tttattttat ccatttttat
     2701 ttacaatcac atcattagca atttattcca tgatatcgta caagagaaat aagcaaattg
     2761 tagattttat aagaaagact aatagaaaaa atcaaaaatt agaaatcatt aaaagtgctg
     2821 taaatttaat ggatgaaggt aacttagaaa aaagtataga tattgagtat gacttagata
     2881 tattaaagga taaagaaaag gatgatattg atgaactagc acataaaatc aataatatag
     2941 tccatcaact tagaaatata actattgaag agagacaagc tcagcagaca aaaacagatt
     3001 taataacaaa tgtgtcacat gacttaagaa cacctttgac atccataatg ggttatttag
     3061 gagtgataga agaaggtaag tataaagatg aagttcagat gatgtattat gttgatattg
     3121 catatgaaaa atcgaaaaat ttaaatgttc ttataaatga tttgtttgaa ttgactaaaa
     3181 tgcaaaataa tacaataaaa ttaaacaaaa tagaaataaa tttagtagag ttattaagtc
     3241 aagtagtatc tcaatttgaa atttatttta aacaagaatt tatggttagt agaattaatt
     3301 ttaatgaaga aaaattaatt gtaaaagctg atccaaataa attggtaaga gcatttgaaa
     3361 atcttataac taatgctgtg aaatatggaa aagatgggca ttatgtagat atagtcacag
     3421 agaaaaagga agatatggcg gttgtaaaag tgataaatta tggggaacca attccagtgt
     3481 tagatttacc aaatatattt gatagatttt atagagttga aaaatcgaga aatagaaatg
     3541 ttggaggttc tggattgggt cttgcgatta caaaaaatat tgtaaattta catgatggag
     3601 aaattactgt ttcaagcgat aaatatcaaa ctgtgtttga agtacaactg ccaataatac
     3661 aatcagctta gttataaaat aaaagtacga ttatgtgata taaatattat aacaataaag
     3721 tgtttacaaa aataaaaaag taatatataa tttaagtcag tttaataaga tacttatcaa
     3781 gagttagggg agagagttag ctcagtgatc ctataccaac cttttatcag gtggtcctgc
     3841 taacaacgat gagatgactt gaaataatat actcttctta tcaataatag ataggaagag
     3901 ttttttttag aattaatgta acaaatttta aagtataatg gaggattaaa taatggaaaa
     3961 agtagaaagt tttaagctag accatacaaa agtaaaagct ccttttgtaa gaaagtgtag
     4021 tgtacttgat ggagtaaagg gagataaagt aactaaattt gacttgagat ttttacagcc
     4081 aaatgtagaa agttttggaa ctgctgctat gcacggttta gagcatcttt tagctactta
     4141 tttaagagat acattagatg gtgtaataga cttatctcca atgggatgta gaacaggatt
     4201 ttatttaata ctatggggag atgtagatgc caaaacagtt aagattggtt tagaagaagc
     4261 attaaaaaaa gttcttgaat cagataaaat gccagcagct acagctatag aatgtggaaa
     4321 ctacagagac ttatctttat ttggggcaaa ggaatatgca aaagatgttt tagataaagg
     4381 attttcttta aatatatatg gagaataatt taattggaag agaagatata agcataaatc
     4441 aaagtgaagt tttaagatat ttacaataca gaggtcaaga gatagataaa gaccttaaat
     4501 atactattga tgaatgtgta gctataacta aaaataaaat aaatcctaga tatttatcta
     4561 ggatttatcc tattaaaata aataaagata atgttgtaga attagaggga acaaatttaa
     4621 cattagagag taaagatgta tatgaacttt taaaagaatg taatgagtgt gtaattatgg
     4681 cagctactat agggatagat atagaaaaag aaataagacg acactcttat tcaaatttaa
     4741 caaaaggact aataattgat tcatgtggaa caacagcaat agaagaagtg tgtgacattg
     4801 ttcaaaataa tttagaaaag gtttttttaa agcaagataa atttataact atgcgatata
     4861 gcccaggata tggagattta ccaatagaaa aaaatataga tatattaaac gttttgaatg
     4921 ctcaaaaaca aataggtcta acaattactt ctaatggaat tatgataccg agaaagtcag
     4981 tagtggctat tataggtatt tctaatacaa gaataaataa atctaagaaa gaaaagtcgt
     5041 gtgaaaattg taaaaactat agaaactgta catatagaaa aggagcgaac tcttgtggaa
     5101 ataagacaat atctgaaaaa taatatatta atatttgatg gtgcaatggg aacaatgctt
     5161 caacaaaaag ggttaaagtt aggtgaaaat ccagaagtat ttggtcttca aaatccagat
     5221 aaacttatag aaatacatac agcatactta gaggcaggtt cgaatgtaat tcttacaaat
     5281 acttttggat gtaatgaact aaaattagat agtaagtata ctgtagaaga agtgattgac
     5341 aatgctgttt tggtggctag aaaagctata gaaaatgtag ataatactaa accaagatat
     5401 gtagctttag atattggtcc tataggagaa atgctagagc ctatgggtac tttaagtttt
     5461 gataaagcat atgaaatatt taaaagacaa gtactacaag gcgttaaatc tggagttgat
     5521 gtaatagtaa tagagactat gatggattta tatgaagcta aagtagctgt attagcagca
     5581 aaagaaaact ctgatttacc tattttctgt actatgacat ttgatgaagg tggaagaagt
     5641 tttactggat gtatgccaga atgtatggtg gctactatag aaggtctagg tgtagatgca
     5701 ataggagtta attgttcatt aggacctaaa caacttttac caatagttga aaaaatagca
     5761 tcaagagcta cagtccctgt tatggttcaa gcaaatgcag gtcttccaaa tatagttgat
     5821 ggagaggcta tatatgatgt tgatgcaaaa gaattttttg aaggggttaa aaagttcgtt
     5881 gaagttggtg ctactataat aggtggatgt tgtggtacga atccaagttt tataaaagaa
     5941 atatctgaga atataaattc tgttacaaag ggatgtatcg agaaaattga taaatgtgta
     6001 gtctgttcac catcaaaatt tgtggaagta caatcgccta cagttgttgg agaaagattg
     6061 aatcccacag gtagaaaatc tctacaagaa gcattaaaaa atgaaaatgt tgattatgct
     6121 ataaatttag gtttagaaca agtaaatgct ggagcacaaa tacttggagt aaatgttggt
     6181 cttccagaga ttgatgaaaa aaaactaatg ccaaaattaa taagagagat tcaagcagta
     6241 gtagatacac ctttacaagt tgattcttcc aatgtagagg ccttagagca aggacttaga
     6301 tattataatg gtagaacaat agtaaactct gtaaatggca aagaggagtc tttagaaagt
     6361 atattaccaa tagttaaaaa gtatggttca tgtgtggttg gacttacact tgatgaaaag
     6421 gggataccta aaaaggctga agaaagattt gaaatagcaa aaaggatagt taatagagca
     6481 gtttcttatg ggataaaacc aaaagatata tttatagact gtttatcatt aactgtttca
     6541 gcacaacaag aagaagcaat agaaactata aaagctataa caatggtaaa gacactagga
     6601 gtaaaaacta tattaggtgt ttcaaatatt tcatttggtc ttccaaatag gaaagcactt
     6661 aatgcttctt ttctaacatt agctttaggg gcagggcttg atttagcaat tataaatcca
     6721 aatgaatata gtatgatgga agctatcaat tcttttaaaa tattaaataa cacagataaa
     6781 ggatgtataa actatataaa tcaatatagc aatataaata attcaaaaaa atcggattca
     6841 tctacaaaga ttgataaaga tttgcccttg gatattttag ttgaaagagg attaaaagat
     6901 gaagcaaaaa atgtaacact gaatctttta aaagagaagg atgaaaatta tatattagat
     6961 gagattttaa ttcctgctct tgataaagta ggaaaaagat atgatagtgg agatatattt
     7021 ttaccacaat tgattcaatc agcagaaacg gtaaaagttt cattaaatac aataaaggaa
     7081 actttattaa gtaaaagtag caataatgta tccaaaggaa aaataatagt tgctacagta
     7141 aaaggtgata tccatgatat tgggaaaaat atagtaaaaa taatgctaga aaattatgga
     7201 tatgaagtta tagatttagg taaagatgtc cctattgaag aagtagtgga agttgctaaa
     7261 aagagaaata taaaattagt aggattaagt gcacttatga ctacgactgt tcaaagtatg
     7321 aaagatacaa ttcaggcact gagagataat gagataaatg caaaggtatt tgtaggaggt
     7381 gcagttttga cagaagaata cgctgaagaa atgggtgctg attattattc aaaggatgca
     7441 aagtctgctg ttgaaatagc aaagttaaat ttttagcata taaattaaaa taaaggtttt
     7501 actaaatagg atattttata tataatataa atataagttt tagatactta tgtttaaaac
     7561 aataggaatt aatctataat aatgagatta attaatataa aaaatattta tcatcaacat
     7621 taaaaagggc tgggaagtct ggtataactt ccatcagccc tttttagtta aaatcatatg
     7681 ttaaaaagcc caattaccat ttttaaaaat ctgtatttgc tttccatcat aagtctcacc
     7741 aataatatcc atatcagcag aaccaatcat aaaatctaca tgtgttaaac tgtcatttac
     7801 accatgttca tctaattctt catcttttaa attatttcca ccttccagac aagtcttata
     7861 agcagaacca attgcaaagt ggcaagaagc attttcatca tatagagtat tataaaaaat
     7921 tatatccgta ttggatattg gtgagttgta tggaacaaga gcgacttctc ctaaataatg
     7981 agagccttca tccgtttcaa taagtttttc tagtgtatcg agtccctttt cagcagagaa
     8041 atctattatt ttaccatctt taaatgttaa gaagaaattg tcaattatgt ttccaccata
     8101 aacaagaggt tttgtactat aaacagttcc atttacttta aacttatgtg gcattccaaa
     8161 aatctcttca gttggaatat tcggattaaa acttattcca ttagggtctt tggatgctcc
     8221 acttagccaa acatgaccct ttggcaagtc tagagtcaaa tcagtttttg aggatttata
     8281 ttttaaagtt ttaaagttat ttttatttag aaagtccatt ttagatttaa gattttcatt
     8341 atgttcttcc catgctttta tagggtcctg accatctact cttgaacatt taaatatagc
     8401 atcccacagt ttttctattg ctttatcttc tgataaattt ggaaacactt tttttgccca
     8461 atcttttgtt ggcacagaga ctatactcca tttacattta tcagttagag tgtaagaacg
     8521 ccattctttt aaagcttttc cagatgcctt ctgaaaattt gcaactcttt cagggtcaac
     8581 atcttttaat aaatctggat tttgggcata gactgataaa aatgccccac cttcttttgc
     8641 tatatctaca tattgttctg ctgtccattt ggggaactca tgaaatgctt catctggagc
     8701 atataagtat ttaataagag tactttcttc atcagaccac tctatataaa catttttagc
     8761 accacattta tatgcttctt taagtgcatt tcttgcaaaa tcagcacatt ctattggtga
     8821 ctttataagt agaatttgac ctggctgtat gttaactcca acttttattg ctaattcagc
     8881 gtatttttct aaatttctat ttaaattcat atttatcctc ctatattttt aatattgaat
     8941 aacttataaa gtattataac attacttatg tttttaatat tgaacaactt ataaaatatt
     9001 ataactttac ttagattttg ggtcatattc aaaatattta tactttatag attgagaaat
     9061 aaaaaaaata ttttaattaa aacagattat gaggataaca aacttattta agcagtatgt
     9121 tttttgttga taataatatt aaagtagaaa taaaaatact tttttagtga aaagctatac
     9181 aagaataccg aaaaaaactt ataatataat aatgagatag atatttataa atgaaaaaaa
     9241 atttttctgg caaagcttaa ttaaaaagtt aatagctagt gttgttattt aaattagcat
     9301 agaaaatcaa ataaaaaaat tatgctaatg tatagacatt gataaggtag aatttaagcc
     9361 ttttgaatgc tatattaaac tagagtagat attcttatga atttcaaaat agggcaggag
     9421 gaaaaaggaa ataaaactat aaaaaatata aagtatttat ataaatttat agagtttata
     9481 cgtcagaaga tttcagttag gagggcataa atggagcttt atgaagccat tttttataga
     9541 aaatctgtaa gaaatttttc cagtaaaaag ataaaaaagc cattgatgga agaaataaaa
     9601 agaagttgta aaaatttaga atacttaaat gaagatttaa atattaaagc acatgttgtt
     9661 gatagaggtc atataataca ttttttgatg ggtaaggaat gtaaagtaaa ggcacctcat
     9721 tatatagtag ttacatcaga caaaggtgag gactatttac agaatatagg atttgctaca
     9781 gaaggtgtag ttttgcgcct tacaacattg ggaatagcta cttgctggtt ggaaggaaac
     9841 ttaaagagag aagatatctt ggaatttgta gatattggga ataagaattt tgaagaagat
     9901 gaggaagatg atttagatta tctagctgga ataaaaacag aagaagatga tgaaaacaaa
     9961 atagaaaatc cttatataat aatagcattt ggatatccag caaaaaatga agagttgttt
    10021 aggacgagat atgctagacc tgatagaaag ccagtaaaag atatgataaa taagataaat
    10081 aggaatagaa agtggaaaga tatcttagaa ttgacaagaa gagctccatc tgtaaaaaat
    10141 tctcaaccgt ggtatttcca taaggatgaa cgaggtcttc atttatttga aaagagacct
    10201 aagaaacact gtgaagatat gaataaggtt agcttaggtg tagccttaag acattttgat
    10261 atagcttgta taaaaaataa aatagatgtt tcatatgaaa aacttcctat aaggaataaa
    10321 ataggaaaat catattttat aactgtagtc gagcatgtga aaccagaaga agaaacccaa
    10381 gaagaaaatg taactctaga aaaagaagaa tcgcaagatg aataaaattt tggaagggga
    10441 tattggatat gtataagtgt ggaaaatgta atcttagagg ctgttctaat ggaaatatgg
    10501 ataaattaat gaagatatgt ccaactagag aaattgaact acaacaaaaa gcaaagcaac
    10561 tttatgaaga agaagagaat agaaaaatag cttataatgc tggattagtt gaagcagagg
    10621 ggtattgtca atatactaga ctaaaagaga ttatagagtt tgctaaaaag tgtggttata
    10681 aaaagattgg catagcattt tgtattggac taaaaagaga aatgcaaaca gtgcaaaaaa
    10741 tatttgaaca tcatgggttt gaagtatttt ctgttatatg taaaaatggg gcaatgccta
    10801 agagtacaat tggactagaa gcatctcaaa caatatcaaa gtgttcagat gaggtaatgt
    10861 gcaatccaat aggacaagct ttatttttaa atgaagctaa ggttgacctt aatgtaattc
    10921 ttggattatg tgttggtcac gatactttag ccatgaaata tatggaagct cctataacaa
    10981 ctttagttgt caaagataga gtaactgggc ataatccagt tgctgcaata tataatgcag
    11041 aatcatattt tgagaaaaaa ttgtttgata aagatgaaga ataattcaaa gacttattga
    11101 cataaaaagc aattagtggt ttaattataa aaaagataaa actttaaatt atcctataga
    11161 tacataaagt tatataaata aagaaaaata ttacagctaa attccttaaa gtagtccaga
    11221 gagactaaag ggttatagat aatgttagta tataacctct agtaaatctt ctagaggttt
    11281 ttgatgagta taaaataaaa atttaaatat aataaagtct tttaaactag tccagagaga
    11341 ctgggaaaga tatctcatag ctaatgaata gagttatgta tagataaaat ccttatgcct
    11401 cttttggtgt gaggattttt ttatgattat ttaggcttta ttaaaaagga gatgtaaaaa
    11461 tgataaatgg taaagaaaaa ttgatagttg caattgatac tgacgaattt gataaagcta
    11521 aagaactaat agacagatta gaagatagtg tagacatatt taaggtaggg ctagagcaat
    11581 acgttgccac aaaaggtaaa acaatagatt atcttaaaga aaaaggtaaa aaaatatttt
    11641 tagaccttaa attccatgat ataccaaata ctatgaaaag tgcagtgaaa gctgcagtga
    11701 gagataatgt ttggttaatg acaatacatg tatcagatat ggaaggaatg agacaatgtg
    11761 cactaattgc tagggaagaa gcagaaagat taaatataga aaagccatta gtagttggag
    11821 taacagtttt aacttcatta agcaaccaag atttacagga cataggatgt aatatgacaa
    11881 cagaagagtt agctataaag agagctaaac tggcaaaaga atcaggaata gatggggttg
    11941 tttgttcagc gcaagaagta gataaaatag tagaagcatg tggaactgat tttataacag
    12001 tttgcccagg aataagacct aaatcagcag aggttggaga ccaaaaaaga gttgtaactc
    12061 catcagatgc aataaaaaaa ggtgctcatt atttagttgt tggaagacct ataacaaaag
    12121 cagaaaatcc aagagaatca gctattaata ttgtaagaga aatagaaaat gcttagataa
    12181 aatatttggg aggtagctta catgaagggg aaattaattt tagaagatgg aacagtattt
    12241 gaaggaaaag catttggata tctaaaggaa gctattggag aagttgtatt taatacttca
    12301 atggctgggt atggagaact attgacagat gcaacttatt atggacaaat agttactatg
    12361 acttatccac ttataggaaa ctatggaata aatttagaag atgttgaatc aaataaggtg
    12421 caagtaaaag gacttattgt aagagaaaaa agtgataacc caaataattt tagatgtgaa
    12481 atggatatag acacatatct aaagcaaaat aaggtaatag gacttgaagg aatagataca
    12541 agagcattaa ctaaaattat tagaaacaat ggaactaaga gaggaattat aactttagaa
    12601 aatgtatcat tacaagatgt tcagtctaaa ttagaagagc attgtaacaa agattcagta
    12661 aaaaatgtta caagaaaaga aattgaaaat ataaaaggta ctggagctaa agttgtagtt
    12721 atagactttg gtgttaaaaa tagtgtacta gagtctctta aggcttgtaa ctgtgatata
    12781 actatagtac cagcaatgac tacagtagaa gaaattttaa atataaatcc tgacttaatc
    12841 ttattatcta atggcccagg aaatccagag gatataaatg atatagttga aaatataaaa
    12901 aaattaatag gcaaaaagcc attgacagga ataggtttag gacatcaaat tttagcattg
    12961 gcattaggag gaaagacttc aaagcttgta tttggacata gaggaggtaa tcacccagtt
    13021 aaatgtttag aaactggaaa ggtatttata acttctcaaa atcatggata taatgtttca
    13081 gaaatgccag aaaatacaga agtaactcac ataaatttaa atgacaatac tatagaagga
    13141 atgagacata aggaattacc aatatatagt gttcagtaca ttccagaata cacaacaaaa
    13201 gaagatttag attgtatatt taataaattc ttagcattaa tatagattta gtattattta
    13261 cagatagtaa aaaccattta gataaggaga aaaatttatg cctaaattag atagtataaa
    13321 gaaaacttta gtattagggt caggaccaat aataataggt caagctgcag agtttgacta
    13381 ttcaggaaca caagcttgcc agtctttgaa agaggaaggg attgaagttg tattaataaa
    13441 tagtaatcca gccactataa tgactgataa agaagtggca gataaaatat atatagaacc
    13501 attaacaata gaatttatag aaaaaataat agaaaaagaa agaccagaca gtttacttgc
    13561 aggtatgggt ggacaaacag ggctaaacct agcagttgaa ctttatgaaa aaggcatact
    13621 agataaatat ggagtaaaaa taataggtac ttcagtagaa tctatcaaaa aaggtgaaga
    13681 tagagatata tttagagaag taatgaaaga aataaatcag cctgtaatag ttagtgatat
    13741 agttacagat ttacaagcag gtcttgatta tgcacttaca attggttatc cagtagttgt
    13801 aagaccagca tacacactag gtggaactgg tgggggtata gctgataatg aggaagaatt
    13861 aagagaaata ctttcacatg gtctacaatt aagtcctgtt ggacaagtat taattgaaaa
    13921 gagtataaaa ggttggaaag aaatagaata tgaggtaata agagattcaa agggaaattg
    13981 tatagttgta tgtaacatgg aaaatataga cccagtcgga gttcatacag gagacagtat
    14041 agttgttgct ccaactcaaa ctttaagtaa caaagaatgt gcaatgctta aaaaagcatc
    14101 tttagatata ttaaatgcag tagaagttca aggtggttgt aacgttcaat ttgcacttaa
    14161 tccacatagt tttgaatatg cagttataga gataaatcca agagttagta ggtcatcagc
    14221 tttagcatca aaagctacag gatatccaat agctaaagtt tcatcaaaaa tagctttagg
    14281 ttatacttta gatgagatag aaaatgcagt aactaaaaaa acttatgctt gttttgaacc
    14341 aactatagat tatgtggtgg caaaaatacc aaaatggcct tttgataaat ttaaaaaagc
    14401 aaatagaaaa ttaggaacta agatgatggc aactggtgaa attatgagta taggaagtaa
    14461 ttttgaggct gctattctta aagggataag atcacttgaa acaggaaaat attcattagt
    14521 tcacacacca tctgaggaga gaagcattga ggaattaaag aaaagagttg tagtacctga
    14581 tgatgagaga ctatttgatt tagctgaaat gataagaaga ggctataaag tagaaatgat
    14641 agaacaaatt acaggtatag ataaatggtt tataaataaa tttaaatgga tagtagagca
    14701 agaagaaaaa ttaaaagtta tgaaaattga agatttaact aaagactatc ttcttgaatt
    14761 aaagaaaaag ggattctctg ataaaggtat atctgaccta atgaagataa gtccagaaaa
    14821 attatatgaa ttgagaagtc tatacaatat caaaccagca tataaaatgg ttgatacttg
    14881 tgcaggtgag atagatgcta tatctcctta ctattattca acttatgagc aatatgatga
    14941 ggtagttgtt agtgataaga aaaaggtgat agtattaggt tctggtccaa taagaatagg
    15001 tcaaggtata gaatttgact attgttcagt tcactgtgta aaatctttaa gaaaaatgga
    15061 catagaaact ataatcataa acaataaccc tgaaactgta agtacagact ttgatacatc
    15121 agataagctg tattttgaac cattaacaga agaagaagtt ttaagtataa tagaaaaaga
    15181 aaaaccagaa ggtgtaatac tacagtttgg tggacaaaca gctataaaat tggctaaatt
    15241 tttacatgaa aaaaatatac ctatactggg aactgatttt gatgatatag atgcagcaga
    15301 agatagagaa aaatttgatg atttactaga gagactagat ataaatagac caaaaggaaa
    15361 gggtgtatgg tcacttaacg aaggtattga agttgctaat gagttaggtt atccagtatt
    15421 agttagacca tcttatgtac ttggtggtca aggtatggaa ataacttata acgaagaaaa
    15481 attatctcaa tacctacaag atgcatttga tagagaccat aaaaatccag tacttataga
    15541 taaatatcta actggtagag aaatagaagt agatgctata tgtgataagg aagatatatt
    15601 gatacctggt ataatggaac atttagaaag agctggagtt cactctggag atagtacaac
    15661 aatgtatcca agtcaaaata tatctgatga aataaaagaa aagatagtag aatacactaa
    15721 aaaaatagct ttagacctta atgtgcttgg tatggttaat atacagttta tagaatttca
    15781 aaatgaatta tatataattg aggttaaccc tagagctagt agaacagttc cgtatataag
    15841 taaagtaagt ggagtaccaa tagttgactt ggctactaag tgtatgttag gagctaaatt
    15901 aaaggattta ggatat
//
LOCUS       DAEQCW010000085        15754 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.086, whole genome shotgun sequence.
ACCESSION   DAEQCW010000085 DAEQCW010000000
VERSION     DAEQCW010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15754)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15754)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15754
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.086"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            202..1419
                     /locus_tag="KRO40_002689"
     CDS             202..1419
                     /locus_tag="KRO40_002689"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase"
                     /protein_id="HBH2093506.1"
                     /translation="MMNVTLTDVKEARETIKNIVKRTDLLESVKLSEKTGANVFYKCE
                     NLQKTGSFKLRGACNKIASLTDEEKANGVIASSAGNHAQGVALGAKMTGIKSTIVMPA
                     TAPLAKVSATKGYGAEVVLNGAVYDDAYAKAVEIQKETRATFLHPFNDKYVIAGQGTI
                     SLEIFEQLDNKVDTILCPVGGGGIISGVAVAAKALNPNVKIVGVQTANIPSMKESIKN
                     GKVTTAFNDTTIADGIAVKTPGDLTFEIINELVDEIVVVEETEIAESILFMMESQKIV
                     SEGAGAVCTAAILSGKYVPAKDENVVCIISGGNIDINTLYRIIGVALAKEGRRYSFST
                     IMEDKPGNFAELTRIISENGGNILSANQGKLSAGEALGKQSAEFILETIDYDHIARIK
                     KAIEEKGFKIIEL"
     gene            1514..1894
                     /locus_tag="KRO40_002690"
     CDS             1514..1894
                     /locus_tag="KRO40_002690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBH2093507.1"
                     /translation="MKHEVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVV
                     EGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYFGENKP
                     ARACVEVARLPKDVKVEIEVIAVL"
     gene            2178..2660
                     /locus_tag="KRO40_002691"
     CDS             2178..2660
                     /locus_tag="KRO40_002691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBH2093508.1"
                     /translation="MLNFFKKNKSYKLHAVVSGNSINIEKVNDSVFSKKLMGDGVAII
                     PNSNVVVAPCNGKVTVLTESKHAFGMVSDEGVEILVHIGIDTVSLQGEGFKNEVSQGD
                     TVKKGSPIISFEREKINSQGIDCTTIIIVLNHSEFSEINCMVENEVVAGQDTVIEIMK
                     "
     gene            2681..3496
                     /locus_tag="KRO40_002692"
     CDS             2681..3496
                     /locus_tag="KRO40_002692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBH2093509.1"
                     /translation="MRVVKIFNNNALSTVTNDRKEAILLGLGIGFNKRPGDKVNEDKI
                     EKIYYVQDHMQTKFLELLKNVSPEVMDASQQIISLIPGNEGKFNNKGILSLVEHISFA
                     IDRMKNNVFLPNLMLLDIKMMYSKEFELGVKALEIIYRVCHIHLPEDEAGYIALHFVN
                     LQSNDNLAYDTLKFVKGSIDLIKECYGLELDESSLSTLRFRTHLKFLAQRIFKNEICQ
                     DDKMIEMYDYLINNHPKNKEYLEKLNVYIEKEFRYKLDKPEKIYLLLHLTKIL"
     gene            3547..5097
                     /locus_tag="KRO40_002693"
     CDS             3547..5097
                     /locus_tag="KRO40_002693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2093510.1"
                     /translation="MKEKLLGGLETFAKAMVQPLMYLSSAGILMVVGVLLTNDMLLGV
                     LPFFKWEPIQIFGSLIYNCIMAIINNLAVIFAIGIPAALAKKEKHKAALIGFMSYIIY
                     LTASNTMLTSLGQLAKESKMLGLIGTGQATILGIQVVDTSVFGGIILGCIAGYVFNRT
                     SNKTFKGALQIYSGANFSFICMFFVSILIGVVSNFIWPLAQQGIASLANVIKDTGTFG
                     LFLYGFLERILVPTGLHHLIYTPFQFSDLGGVLKVGADTVSGAYAIVMTEMNLPVERF
                     SDSIYYMATGFTKMFGYIGIGAAFIYTAYKQNKKKVKATIIPLIITAVLASVTEPLDF
                     MFVFCAPFLFFVHAVIAGLFIALLKIFDVTALCGGNLLVSIIMNTTVGVEKTHWPVMM
                     ILGLAQIIVYFVVFSFLIKKFNYKTPGREDESTATGEEQSKQLNLDAGIENIIDGLGG
                     KENINTVENCITRLRVNVKDESKINEDIINLTPNSGIVRKGKDIQIIFGLHVHEVRRA
                     VEDFLEAY"
     gene            5194..6546
                     /locus_tag="KRO40_002694"
     CDS             5194..6546
                     /locus_tag="KRO40_002694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBH2093511.1"
                     /translation="MIITIVGGGSTFTPGIVKSIALREKELELEEIRLFDIDKERQDK
                     VAVVVNWILKEDVKTDVKLTVTNCEKEAYTDATFIFAQMRVGKYEMREQDEKIPLKYG
                     CVGQETCGCGGMAYGLRTIQPMIKVIDDVEKYAKKDYWILNYSNPAAIVSEACRKLRP
                     NARIINICDMPIAIIDMIAGSLNINDVHNIRYDYFGLNHFGWFTSIDYKHRDLMEEIK
                     EYIKENKILLPKSYIENLNKSRSTGNRHAVSSWIHVWESVYTMLESFPKYLPNTYLTY
                     YLLSKETVEHSNINRTRANEVMESREKDLFEGVRHYLETGEISEKAFYAGSHGDWISD
                     LAVSIKNDTRSRFLVITENRGAIPNMPYDAMVEIPAYIGKDGPEVIARGPIPLFQQGL
                     MMQQLNSEKLIVEAYIENSYEKALQAFTLNKTIPSMNVAKEILDEMIEVNKEYWPELR
                     "
     gene            6677..7435
                     /locus_tag="KRO40_002695"
     CDS             6677..7435
                     /locus_tag="KRO40_002695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093512.1"
                     /translation="MNIINKIFWEEDRIGMITNNLEADTHSHCMLQLFLGIEDSIEIT
                     VNEKLVKCNCIIVDKNISHSFSARKKVYYSAIIEPTSIYAEQLTSKMNDFGYWICDND
                     GLEKLRQQGTFLIDNSSKEQYLRFMEMLNNYLNIPITLKHYDDRITELLNLLRTCNCD
                     NHTISSFADKVSLSASRLSHLFKEQIGIPLKSYILFHQMECAFRELLSGKNVTEASMT
                     AGFDTPSHFAGTVKRMMGMPVSLSLKDSEFLKVY"
     gene            7482..8201
                     /locus_tag="KRO40_002696"
     CDS             7482..8201
                     /locus_tag="KRO40_002696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBH2093513.1"
                     /translation="MNKEYLEETKMLNYNEPQLKLLVSSKNWLELDDFHKIKSIYEFV
                     QNDILFGYNASDMLSATQVLNDGMGQCNTKATLLMALLRAVNIPCRLHAFDVTKDFQR
                     GATSKLISLLAPKYILHTWVEVFYQDRWIALEGVITDKKYLEAIQKKFFNHGGTFKKY
                     AIATNDLKNTSIDWDGKDTFIQKEAIVYDYGIFPSPDVFFSTHSQHMSKLKNFIYVHL
                     IRKIMTKNVCKARNNYIDKNE"
     gene            complement(8325..9725)
                     /locus_tag="KRO40_002697"
     CDS             complement(8325..9725)
                     /locus_tag="KRO40_002697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HBH2093514.1"
                     /translation="METQSNNKKGNLIIAIVMTGAFISSLSQTLLSTALPNIMSDFKI
                     TADIGQWLTTIYLLIAGIIVPTTAYLINRFSTRKLFITSMSIFSIGCIIALFSNNFST
                     MLIARVLQAMGSGSLMPLLQVIILYLCPEEKRGAAMSLVGITVGFAPAIGPTLSGWLV
                     DSFGWHSLFLFLSPIAILDVILSFILLRNVGETQKLKLDIPSIVLSSLGFGGLLIGFT
                     NQGNYGWTNIATYLPILIGIMSLILFTLRQLKSKEPFLELRVFKNKPFLISTILIMIV
                     YASMMSATLMIPLYVQSVRGFSALSSGSLMLPGAILMVVLNPIAGRHLDKYGPHALSI
                     LGTGCLFLGTLSFAFLGRDTSLIHVSLMYCIRMIGISMVLMPLTTWGIKTLDRELISH
                     ATAINNTLRQISGAIGSAILITIMTSATKKAHMSSNMLSNIHGIDVAFSIAATLAFTG
                     LIVSICFIKRHQIIRS"
     gene            complement(9729..10637)
                     /locus_tag="KRO40_002698"
     CDS             complement(9729..10637)
                     /locus_tag="KRO40_002698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093515.1"
                     /translation="MKGDNKVTEKQRLIITIAQKIFDQKGFQNTSISDVVKECKMSKA
                     TFYKHFETKESFICEIINYYDEKFLEIIHSINENNDIPSSEKLNRKIIAVWKNIFSRT
                     TINTYIRENFSEEQRKATSKLQTKSRANLLNEYKLSLFDNYGDKIEKIIFDLVFLLDA
                     LIHQFIYIIHVQKREINVYFIAKFTIQILDLVVENMDNLNPLIEKSMFLHKQEDEVYF
                     SLHNKSLFFKTIQDIEELIKTDTSLLENPKLLEAIKKLYVEGKNQQYDSLIMDAMIAY
                     LEKEDTLRPKVLLLNSIKNQLKKETL"
     gene            10898..11545
                     /locus_tag="KRO40_002699"
     CDS             10898..11545
                     /locus_tag="KRO40_002699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH2093516.1"
                     /translation="MKKKICVAIIFALFIVFVEMFIDSSSEGSKIMTAELSKYRKGVN
                     VLSINNIIVANKKYSLPKDYSPQESSEARDAFYKMNKDAQKSGLNLKAFSTYRSYEYQ
                     DRLFKSYVKEHGEKEANRFSAKPGESEHQTGLAFDIGGDDQSCWANKKFNNTKEAKWL
                     YENAYKYGFILRYPEGKENITGYMYESWHYRYVGTEHSKNFAMNNLTLEEYLHIN"
     gene            11870..14509
                     /locus_tag="KRO40_002700"
     CDS             11870..14509
                     /locus_tag="KRO40_002700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBH2093517.1"
                     /translation="MSYKSTYQEVIKNLDSSLSGLSKERAEELLEKNGANELKEADKV
                     PTYKLFLESFKDPLVIILLIAALVQIFLGETVESIIIFAVIIINSVLGVVQTKKAESS
                     LESLKNLSAPNAKVIRDNKKMTIPAKNLVVGDIVFLEAGDYIPADGRLIEAQSLKVVE
                     GMLTGESEPVLKHIEKISEDVSLGDQKNMVFSGAVVVYGRGSFVVTGTGMNTEMGKIA
                     GLLESAENKLTPLQQKIEDFSKKLGVGIVILALLIFIIQVARNYFMAGNGEMTQIILD
                     SFMFSVAVAVAAIPEALSSIVTIVLAVGTNSMAKKQAIIRKLPAVETLGSTSVICTDK
                     TGTLTQNKMTVVDYYMYGTNNDELDKEKVNYSYHAKLLTMVSTLCNDSHITSDGKEVG
                     DPTEVALINYSSKNDLDYDKLRSKYIRINEIPFDSDRKLMSTVNSIYGDYIMFTKGAP
                     DIVFSRCKYALKNGSKVDITDEIIEEYKHKNEEFSNRALRVLAFAIKDVPEEDFIPSI
                     DDEHDMTLVGIMAMIDPPREEVMDAVKEAKSAGIKTVMITGDHKTTAAAIAKEIGIME
                     EGDLALTGKELDALSEEQLYEKLENISVYARVSPENKIRIVKAWQHKNNITAMTGDGV
                     NDAPALKQADIGIGMGSGTDVAKDASAMVLVDDNFASIVNAVEVGRTVYSNIIKSITY
                     LFAGNLGAIVSIVFAVFAGWSNPFTALQLLFINLVNDSLPAIALGFEKSEKNIMNKPP
                     RHPDESILAGGTLKAVAIRGCIIGVVTIIAQYIGLQVSPELGVAMAFSTLILARIMQT
                     LPARSNNQTVIKLGFFSNKYVIGAVLVCLGLYSLTLIPVLRGIFSIPTTFGLYQLGIC
                     LGLALISSILMELNKLINRSEVK"
     gene            complement(14567..15670)
                     /locus_tag="KRO40_002701"
     CDS             complement(14567..15670)
                     /locus_tag="KRO40_002701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate aminotransferase family
                     protein"
                     /protein_id="HBH2093518.1"
                     /translation="MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNK
                     AVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIALDTDRICLADGSIHVIYLLNRLF
                     IEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
                     IDNPNNPTGQIIPLSSIENIVKEAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVI
                     ALKTFSKGFGLAGLRAGYAVLPEQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEE
                     LKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQEFAKLKIRVISGSD
                     FTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE"
BASE COUNT         5933 a         1897 c         2749 g         5175 t
ORIGIN      
        1 aaatattttt aaattatcat ttaatgtaat ttaaatgaat tgaagatata tgtttattgt
       61 atgcaattgt tgtattttta ggttttttgt gattaattaa aaaattataa aaatcgttta
      121 catgttgatt tttaaaaaaa aaagatatag aattatatag aaagtaataa acaaaaattg
      181 gatttacggg agtggaatga aatgatgaat gttaccttaa cagatgtgaa agaggctaga
      241 gagaccatta agaacatagt aaaaagaact gacttacttg aaagtgttaa acttagcgaa
      301 aaaacaggag caaatgtgtt ctataaatgt gagaatcttc aaaaaacagg ttcttttaaa
      361 ttaagaggag cttgtaacaa aatagcgagt ttaacagatg aagaaaaggc aaatggagtt
      421 atagcttcaa gtgcagggaa tcatgctcaa ggagttgcat tgggagcaaa aatgactggt
      481 ataaaatcta caatagtaat gccagcaact gcgcctttag caaaagttag tgcaactaaa
      541 ggttatggag cagaagtagt tttaaatggt gcggtttatg atgatgcata tgcaaaagct
      601 gttgaaatac aaaaagaaac aagagcaact ttcttacatc cattcaatga taagtatgtt
      661 atagcaggac aaggaactat atctcttgaa attttcgaac aattagacaa taaagttgat
      721 actatactat gcccagttgg tggaggagga atcatctctg gtgttgctgt tgcagcaaaa
      781 gcattaaatc ctaatgtaaa aatagtcggt gttcaaactg caaatatacc ttcaatgaaa
      841 gagtcaataa aaaatggaaa agtaacaaca gcatttaatg atactacaat agctgatggt
      901 atagctgtta aaactccagg agatttaact tttgaaataa taaatgaatt ggttgatgaa
      961 atagtagtgg ttgaagagac agaaattgca gaatcaatat tatttatgat ggaaagtcaa
     1021 aaaatagttt cagaaggtgc tggtgctgta tgtacagctg ctatattaag tggtaagtat
     1081 gtaccagcaa aagatgaaaa tgtagtttgt ataatatctg gtggtaatat agacataaat
     1141 acgttatata gaataatagg tgttgcttta gctaaagaag gaagaagata ttcatttagt
     1201 acaattatgg aagataagcc aggaaacttt gctgagttaa ctagaataat aagtgagaat
     1261 ggtggaaaca ttttaagtgc taatcaaggt aaattatcag caggggaagc tctaggaaaa
     1321 caaagtgcgg aatttatatt agagacaata gattatgacc atatagctag aataaagaaa
     1381 gctatagaag aaaaaggttt taaaattata gaattataat aaaaagtgta tataatatac
     1441 aagaaaaata gtataatagt gtatgaagat acattttatg tgtattagat taacgaatta
     1501 ggaggatttt aaaatgaaac atgaagtaat acatactaat gatgcaccag cagctttagg
     1561 accatattct caagctataa aagctggaaa cttgttattt gtatctggac aagttcctct
     1621 tgtaccagag actatggaag tagttgaagg agatgtacaa gctcaaactg ctcaatcttt
     1681 aaaaaatctt aaagctatat tagctgaaag tggagctgat ttttcaaatg tagttaagac
     1741 tacagtattt ataaaagata tgaatgaatt tggggctata aacgaagttt atgctgaata
     1801 ttttggagaa aataaaccag caagagcttg tgtagaagtt gctagattac caaaagacgt
     1861 taaagttgaa atagaagtaa tagctgtatt ataaaaatac aatattttta atttgaaaag
     1921 gctgaaaaac tatattctag tgattcagcc tttttataaa aaaataaatc acaataaaga
     1981 acatgataaa tattgtcgaa ttaaaaaata aaattaaaat aaatattgca atatttttga
     2041 gaaggtttta taatgagtat ataatttgaa acgtgtaact attaaattag gcatgagttc
     2101 ttggatattt ttatcctgag gattcatgcc ttttttgtat tgaaattcaa aaatctattt
     2161 aataaggagg aagtactgtg ttaaattttt tcaagaaaaa taaaagctat aagttacatg
     2221 cagtagtgag tggtaacagc attaatattg agaaagtaaa cgattctgtg ttttcaaaaa
     2281 agttaatggg agatggagtt gcaattattc ctaatagtaa tgttgttgta gccccttgta
     2341 atggtaaagt aactgtgctt acagaatcaa agcatgcctt tggtatggtc tcagatgagg
     2401 gtgttgaaat attagtccac ataggaattg atacagttag tttacagggt gaggggttta
     2461 aaaatgaagt gtctcaagga gatactgtta aaaaaggtag tccaataata agttttgaaa
     2521 gagaaaaaat aaattctcag ggaattgatt gtacaacaat aataattgta ttaaatcata
     2581 gcgaattttc agaaataaat tgcatggtag aaaatgaagt tgttgcaggg caagatactg
     2641 ttattgaaat tatgaaataa taggaaggga ttaattcaat atgagagtag taaaaatctt
     2701 taataataat gcattatcta cagtaactaa tgataggaaa gaagctattt tactaggtct
     2761 tggtataggt tttaataaac gtccaggaga taaagttaat gaagataaaa tagaaaagat
     2821 ttattatgtt caagaccaca tgcaaacaaa atttttagaa ttattaaaaa atgttagtcc
     2881 agaagtgatg gatgcttcac aacaaattat aagtcttata ccaggaaatg agggaaaatt
     2941 taataataaa gggatattat ctttagtgga acatattagt tttgcaatag atagaatgaa
     3001 aaataatgtt tttttaccta atttaatgct tttggatata aagatgatgt attcaaaaga
     3061 gtttgaatta ggagtaaaag ctttagaaat tatatataga gtatgtcata tccatttgcc
     3121 tgaagatgaa gcaggttaca tagctttaca ttttgtcaat ttacaatcaa atgataattt
     3181 ggcatatgat actttaaaat ttgtaaaagg tagtattgat ttgattaaag aatgttatgg
     3241 attagaatta gacgaatcga gtttaagtac attacgtttt agaactcatc ttaaatttct
     3301 tgctcaaaga atttttaaga atgaaatttg tcaggatgat aaaatgattg aaatgtatga
     3361 ttatttaatt aacaatcatc ctaaaaataa agaatattta gaaaagttaa atgtatatat
     3421 tgaaaaggag tttaggtata aattagataa acctgaaaaa atttatctac tactacacct
     3481 aacaaaaatc ttataagaat gagatgaatt agtaatagaa atatataatt ttaggggggg
     3541 ataagattga aagaaaaact acttggagga ctggaaacat ttgcaaaggc aatggttcag
     3601 ccattaatgt atttatcgag tgcaggaata ttaatggtgg taggtgtact acttacaaat
     3661 gatatgttat taggagtact tccatttttt aaatgggagc caattcaaat atttggaagc
     3721 ctaatttata actgtataat ggctattatt aataatcttg ctgttatatt tgctataggt
     3781 attcctgctg cactagcaaa aaaagagaag cacaaagcag cgttaatagg atttatgagt
     3841 tatataatat accttacagc ttccaacact atgttaacat cactaggtca actagcaaaa
     3901 gaaagcaaga tgcttggact gatagggact ggacaagcta ctattttagg tattcaagtt
     3961 gtagatacaa gtgtatttgg tggaattatt ttagggtgta tagctggata tgtatttaat
     4021 cgtacaagca acaaaacatt taaaggagct ttacagatat actcgggagc aaattttagt
     4081 tttatatgca tgttctttgt atccatttta attggagttg tgagtaactt tatatggcca
     4141 ttagctcaac aaggaatagc ttctcttgca aatgtcatca aagatacagg tacatttggt
     4201 ttattcttat atggtttttt agagagaata ttagtaccaa ctggacttca tcatttaatc
     4261 tatacaccat ttcagttttc tgatttagga ggagtgctta aagttggtgc agatacagtt
     4321 tcaggagcct atgctatagt tatgacagaa atgaatttac cagttgagcg tttctcagat
     4381 agtatatact acatggcaac tggatttaca aagatgtttg gttatatagg tataggagct
     4441 gcctttattt atactgcata taagcaaaat aagaagaaag ttaaggcaac gattattcca
     4501 ctaataatta cggcagtatt agcctctgta acagaaccat tagactttat gtttgtattc
     4561 tgtgcaccat ttttattctt tgtacatgca gttatagctg gtctttttat agctttatta
     4621 aaaatatttg atgttactgc attatgtgga gggaacttat tagtatcaat tataatgaat
     4681 actacagtag gcgtagaaaa aacacactgg ccagtaatga tgatattagg acttgcacaa
     4741 attattgtat attttgtagt atttagtttt ttaattaaga aatttaatta taaaactcca
     4801 ggtcgtgaag atgagagtac agctacaggc gaagaacaat caaaacaact taatttagat
     4861 gcagggatag aaaatataat tgatgggtta ggcggaaaag aaaatattaa tacagtagaa
     4921 aattgcatca ctagattacg tgttaatgta aaagatgaaa gtaagattaa tgaagatata
     4981 attaatttaa cgccaaatag cgggattgta aggaaaggaa aagatataca aataattttt
     5041 ggacttcatg tgcatgaggt aagacgtgca gtagaagatt ttttagaagc ttattaaaga
     5101 tatatattta tatagcaagg gtaaataaca gctttaagtg ctgtttacta tttattaaag
     5161 atacatataa tttatagagg aggaataatt attatgatta ttactattgt tggtggagga
     5221 agcacattta ctccaggtat tgttaagtca attgcattaa gagaaaaaga gttagagctt
     5281 gaggaaattc gcttatttga cattgataaa gaacgccaag ataaagtagc tgtagttgtc
     5341 aactggatac taaaagaaga tgttaaaaca gatgttaaac taactgtaac taattgtgaa
     5401 aaagaagcgt atacagatgc tacatttata tttgcacaaa tgcgtgttgg taaatatgaa
     5461 atgcgtgagc aggatgaaaa aattccattg aaatatggtt gtgtaggtca agaaacttgt
     5521 ggttgtggag ggatggcata cggactgcgt acaatacaac caatgataaa ggttattgat
     5581 gatgtagaga aatatgctaa aaaagattat tggatattaa attactctaa tcctgctgca
     5641 atcgtttctg aagcttgtcg taagttaaga ccaaatgcaa ggattataaa tatctgtgat
     5701 atgccaatag ctattataga tatgatagcg gggtcattaa atatcaatga cgttcataat
     5761 atacgctatg attattttgg tctaaatcat tttggctggt ttacttcaat agattataaa
     5821 catagagact taatggaaga gattaaggaa tacataaaag aaaataaaat attattacca
     5881 aaatcttata tagaaaactt aaataaaagt cgtagtacag gaaatcgcca tgctgtaagt
     5941 agctggatac atgtttggga atctgtttat acaatgttag aaagcttccc aaaatatctg
     6001 ccaaacactt atttaacata ctatctttta agtaaagaaa cagtggaaca ttcaaacata
     6061 aatcgtactc gtgcaaatga ggttatggaa agccgtgaaa aagacttatt tgaaggtgtg
     6121 agacattact tagaaactgg agaaatttct gaaaaagcat tttatgcagg ttcacatgga
     6181 gattggatta gtgatttggc agtttcaatt aaaaatgata cacgtagtcg ttttttagtt
     6241 ataactgaaa atcgtggagc tataccaaac atgccatatg atgcaatggt agaaattcca
     6301 gcatatattg gtaaagatgg tccagaagtt attgctcgag gtccaatacc tctatttcaa
     6361 caaggattaa tgatgcaaca acttaacagt gaaaaattga tagtagaagc ttatatagaa
     6421 aatagttatg aaaaagcttt acaagcattc acattaaata aaactattcc aagtatgaat
     6481 gttgctaaag aaattttgga tgaaatgata gaagttaata aggaatactg gccagaatta
     6541 agatagtagg ataaaggaaa gggtttttat ttaataatta gatatgtttt cagagtcttt
     6601 tatcaaaatg tattcacaaa catatggcaa tatattaaaa taaagagtga tatttttaga
     6661 agaatggggt gatgcaatga acattataaa taaaattttt tgggaagaag ataggattgg
     6721 catgattaca aataatttag aggcagatac acatagccac tgtatgttac aactgttctt
     6781 agggatagaa gacagcattg aaataacagt caatgaaaaa ttagttaaat gtaattgtat
     6841 catagtagat aaaaatatct ctcattcatt ttcagcaaga aaaaaagttt attactctgc
     6901 tattattgaa cctacatcta tatatgcaga acagcttacc tcaaaaatga atgattttgg
     6961 ctactggata tgtgacaatg atggattaga gaaattacgt caacaaggaa cttttttgat
     7021 agataactct agtaaagaac aatatttaag atttatggaa atgcttaata actatttgaa
     7081 tatacctata actctcaaac attatgatga cagaattact gaattgctca atttattacg
     7141 tacttgtaat tgtgataatc atactatttc aagttttgca gataaagtgt ccctatcagc
     7201 aagtagatta tcacatctgt ttaaagaaca aatagggata cctttaaaaa gctatatctt
     7261 atttcatcaa atggagtgtg cttttagaga attactttct gggaaaaatg ttaccgaagc
     7321 ttctatgact gctggattcg atactccatc acactttgca gggacagtta agcgaatgat
     7381 gggaatgcct gtttctttat ctttgaaaga tagcgaattt ttgaaagtat attaaatatt
     7441 ctcgttatat aatgaagttg tactaagaaa ggggctttgt tatgaataaa gaatatttag
     7501 aggaaacaaa aatgttaaat tataatgaac cacaacttaa gcttttggta tcatcaaaga
     7561 attggttgga attagatgat tttcataaaa taaaatctat ttatgagttt gtacagaatg
     7621 atattttatt tggatataat gcttctgata tgttaagcgc aacacaggta ttaaatgatg
     7681 gtatgggaca atgcaataca aaagctactc ttttaatggc attattacgt gcagtgaata
     7741 tcccttgtag gcttcatgct tttgatgtaa caaaagattt tcaacgagga gctacatcca
     7801 aattgatttc actattagca ccaaaatata ttcttcatac ttgggtagag gtattttatc
     7861 aagataggtg gattgctctt gagggtgtca taactgataa aaaatattta gaagcaattc
     7921 agaagaaatt ttttaatcat ggtggaacat ttaaaaagta tgcaatagct acaaatgatt
     7981 tgaaaaatac atctattgat tgggatggta aagatacttt tatccaaaaa gaagctatcg
     8041 tgtatgatta tggtattttt ccatcaccag acgtattttt ttctactcat tcacaacata
     8101 tgtcaaaatt aaaaaatttc atatatgtac atcttatcag aaaaataatg acaaaaaatg
     8161 tatgtaaggc tagaaacaat tatattgata aaaacgaatg agtgtttaag aggtaactat
     8221 ataggaaata tatagaataa ttaaaactgt actggttaaa atgaataaaa aggagttatc
     8281 acagagcaaa cttaaattgt tcataggata actccttttc tgtattaact tctaataatt
     8341 tgatgtcttt ttataaaaca tatagataca attaaaccag taaatgcaag agtagctgct
     8401 attgaaaatg caacatctat tccatgaatg ttagacagca tgtttgaact catatgagct
     8461 ttcttagtag cacttgtcat tatagtaata agtatagcag aacctatagc tccagatatc
     8521 tgacggagtg tgttattaat tgctgtggca tgagatataa gttctctatc taatgtttta
     8581 attccccatg tagttaatgg cattaaaacc attgaaatac caatcatacg aatacaatac
     8641 atcaatgaca catgaattaa agatgtatct ctgcctaaaa aagcgaagga taaagttcct
     8701 aaaaacaaac atcctgttcc taatattgat agagcatgag gtccatattt atctaaatga
     8761 cgtcctgcaa ttggattgag tacaaccatc aatatagcac caggtaacat taatgaacct
     8821 gaagataatg cagaaaatcc tcttacagat tgaacgtaca gaggaatcat taatgtagca
     8881 gacatcattg aggcatatac aatcataatt aatattgtag aaataagaaa tggtttattt
     8941 ttaaaaaccc tcaattctaa aaaaggttct ttagatttta attgacgcaa tgtaaataaa
     9001 attaatgaca taattcctat taatattggt aaatatgtgg caatattagt ccacccataa
     9061 ttaccttgat tagtaaatcc aattaataaa ccaccaaaac ctagagatga tagtactatt
     9121 gaaggtatat ctaattttag tttttgagtt tccccaacat ttcttaatag aataaatgat
     9181 agtataacat ctaatatagc aataggggaa agaaacagaa ataaactatg ccaaccaaat
     9241 gaatctacta accatcctga taaagttgga cctattgctg gagcaaatcc tactgtaata
     9301 ccaactaaac tcatagctgc accacgtttt tcctcagggc ataaatagag tataataact
     9361 tgtaaaagtg gcattagaga accagaaccc attgcctgca acacacgagc aatcaacata
     9421 gttgaaaaat tattagaaaa aagtgcaata atacatccta tagaaaagat agacattgat
     9481 gtaataaata actttctagt actaaatcga tttattaaat aagctgttgt gggtacaata
     9541 atacctgcaa taagtagata aattgttgtt aaccactgac caatatcagc agtaatttta
     9601 aaatctgaca ttatattagg taatgctgtt gacaatagtg tttgactgag agaacttata
     9661 aaagcaccag tcattacaat tgctattatt aaatttcctt ttttattgtt actttgggtt
     9721 tccataattt ataacgtctc cttttttaat tgatttttaa tgctgttcaa taaaagtact
     9781 tttggtctta aagtgtcttc tttttctaaa tatgcaatca ttgcatccat aattaaagaa
     9841 tcatattgtt gattttttcc ttcgacgtat aattttttta ttgcttctag taatttagga
     9901 ttttcaagga gagaagtatc agttttgatt agttcttcta tatcttgtat cgttttaaaa
     9961 aatagcgatt tattatgaag ggaaaagtaa acttcatctt cttgtttatg taaaaacatt
    10021 gatttttcaa ttaaaggatt tagattatcc atattttcta caactaaatc tagaatttgt
    10081 atagtaaatt tggcaataaa gtatacattt atttctcttt tttgtacatg aataatgtat
    10141 ataaactgat gaattagagc atccaataag aaaactaaat caaatataat tttttctatt
    10201 ttatcaccat agttatcaaa taagcttagt ttgtattcat tcaataagtt agctcttgat
    10261 tttgtttgca atttacttgt agccttacgt tgctcttcag aaaagttttc tcttatatag
    10321 gtatttatgg tagttctaga aaaaatattt ttccatacag caattatctt tctgtttaac
    10381 ttttctgatg atggaatgtc attattttca tttatggaat gtataatttc taaaaacttt
    10441 tcatcataat aattgattat ttcgcagata aaactttcct tagtttcaaa atgcttgtaa
    10501 aaagtagctt tagacatttt acactctttt acaacatccg atattgaagt attttgaaaa
    10561 cctttttggt caaaaatttt ttgtgcaata gttataatga gcctttgttt ttctgtcact
    10621 ttattatctc ctttcacgca aaaacgttta gtactatata gtacctacaa gttttgataa
    10681 atatattata catcatttgg aaaaaaaatc aatatataga ctgtaatatg aaatttttga
    10741 aaaatttgtt gttattttta gtcgtataaa aaagaaactt aagagtttct taagaattgt
    10801 ttaaagaagt tgcaataaat tagtggtatg attatagtat gaaagagaat gtcttgaaat
    10861 ttttctgtat caaattccaa ttatggaggt gtagtatatg aaaaagaaaa tttgtgtagc
    10921 aataattttt gctctattta tagtttttgt agaaatgttt attgatagct ctagcgaagg
    10981 aagtaaaatt atgacagctg aattaagtaa atacaggaaa ggcgtaaatg tattatcaat
    11041 aaacaatatt atagtagcga ataaaaaata tagtttgccc aaagattatt ctcctcagga
    11101 aagcagtgaa gcgagagatg ctttttataa aatgaataaa gatgctcaaa agtcaggatt
    11161 aaatttaaaa gcttttagta catatagaag ttatgaatat caagatagat tatttaagtc
    11221 atatgtaaaa gaacatggag aaaaagaagc aaatagattt tcagctaaac ctggagagag
    11281 tgagcatcaa actggacttg cttttgatat tggaggagat gaccagtctt gttgggcaaa
    11341 taaaaagttc aacaatacaa aagaagctaa gtggttgtat gaaaatgcat ataaatatgg
    11401 ttttatactt agatatccag aaggtaaaga gaatataaca ggatatatgt atgaatcttg
    11461 gcactataga tatgttggaa ctgaacatag caaaaacttt gcaatgaata atttgacttt
    11521 agaagaatat ttacatataa attaagagat ggtttgttaa aattaggtta aaataaaaaa
    11581 taacctagac tattagctgt gtaaagtgat ataatgtaaa tacaatttaa gataactact
    11641 cgaaggggag tagcttacac gaaagtggta attaatcgtc aagacagtag aaatactcgg
    11701 ttaattagca agggattcct tgatagcaag accttcaaaa taagcattag gtatgtttgt
    11761 tttggggtct ttttttattc aaggaatttt tatttaaaaa aatttaaatt tcaagtatac
    11821 ataagagccc ccaaacataa aataaattta ttgaagagga gggcaacaaa tgtcttacaa
    11881 aagtacttat caagaagtaa ttaaaaattt agactcaagt ttatctggtt tgagtaaaga
    11941 aagagcagaa gagttgttag aaaaaaatgg agctaatgaa ttaaaagaag cagataaggt
    12001 tcctacttat aagcttttcc tagaaagttt taaagaccca ttagtaataa ttctattgat
    12061 agctgcttta gtacaaatat ttttaggtga aacagtggag tctataataa tttttgcagt
    12121 tattattata aactctgttc tgggtgttgt acaaacaaaa aaagcagaaa gttcattaga
    12181 aagtttgaaa aatttatctg caccaaacgc aaaggtaata agagacaata aaaaaatgac
    12241 aattccagca aaaaatctag tagttggaga tattgtattc ttagaagctg gcgattacat
    12301 accagcagat ggaaggctta tagaagcaca atctctcaag gttgtagaag ggatgttaac
    12361 tggagaatca gaaccagttt taaagcatat agaaaaaata agtgaagatg taagtttagg
    12421 tgaccagaaa aatatggtat ttagtggtgc tgtagttgtt tatggtagag gttcttttgt
    12481 agtgactgga acaggtatga atactgagat gggtaaaata gctgggcttt tagaaagtgc
    12541 tgaaaataaa cttacaccat tgcaacaaaa aatagaggat tttagtaaaa aacttggtgt
    12601 aggtattgta atacttgctc ttttaatatt tataattcaa gtagcaagaa attactttat
    12661 ggctggaaat ggagaaatga cacaaattat tttagattca ttcatgttct ctgtagcagt
    12721 agcagtagca gctataccag aagctctatc atcaatagtc actatagtat tggctgttgg
    12781 aacaaatagt atggcaaaaa aacaagccat aataagaaaa ttaccagcag tagaaacttt
    12841 aggttcaaca agtgtaatat gtactgataa aacaggtact cttacacaaa ataaaatgac
    12901 agtagttgat tattatatgt atggaactaa taatgatgag ttagataaag aaaaagtaaa
    12961 ctattcttat catgctaaat tattgactat ggtttctaca ttgtgtaatg actctcatat
    13021 aactagtgat ggtaaagaag ttggtgaccc aacagaagtg gctttaataa attattcaag
    13081 taaaaatgat ttagattatg ataaattaag aagtaagtat atcagaataa atgaaatacc
    13141 atttgactca gacagaaagc ttatgtctac tgtaaatagt atatatggag attatataat
    13201 gtttacaaaa ggtgctccag atattgtgtt tagtagatgt aaatatgctt tgaaaaatgg
    13261 ttcaaaagta gatataacag atgagataat agaagaatat aaacataaaa atgaagagtt
    13321 ctcaaataga gcacttagag tattagcttt tgcaataaaa gatgtcccag aagaagattt
    13381 tataccttca attgatgacg aacatgacat gacattggtt ggaataatgg caatgataga
    13441 cccaccaaga gaagaagtaa tggatgcagt aaaagaggca aagagtgctg gtataaaaac
    13501 tgttatgata actggtgacc ataaaacaac agcagcagca attgcaaaag agattggtat
    13561 aatggaagaa ggagacttgg ctcttactgg aaaagagctt gatgctttga gtgaagaaca
    13621 actatatgaa aaactagaaa atataagtgt atatgccaga gtctcgccag aaaataaaat
    13681 tcgtatagta aaagcatggc aacataagaa taatataaca gcaatgactg gtgatggtgt
    13741 taatgatgca cctgcattaa aacaagcaga tataggaatc ggtatgggaa gtggtactga
    13801 tgtagcaaaa gatgcttctg ctatggtatt ggttgatgat aactttgcaa gtatagtaaa
    13861 tgctgttgaa gttggtagaa cagtatacag taatataata aaatcaatta cttatctatt
    13921 tgcaggaaac ttaggagcta tagtatccat agtatttgca gtgtttgcag gttggtcaaa
    13981 tccatttaca gctttacaac ttttgtttat aaacttagta aatgactctt taccagcaat
    14041 tgcattaggg tttgaaaagt cagaaaaaaa tataatgaat aaacctccta gacacccgga
    14101 tgaaagtata ctagcaggag gaacattgaa ggcagttgct ataagaggtt gtataatagg
    14161 tgtagttaca ataattgcac aatatatagg attacaagta tctccagaac ttggagtagc
    14221 aatggcattt tcaacattga tattagctag aataatgcaa acattacctg cacgttctaa
    14281 taatcaaaca gtaataaaat taggtttttt cagcaataaa tacgttatag gagcagtttt
    14341 agtctgtctt gggctttact ctttaacact aataccagtg ctaagaggaa tattctctat
    14401 accaacaacg tttggattgt accagttggg gatttgccta gggttagcat taatttcatc
    14461 aatattaatg gaacttaaca aattaataaa tagaagtgaa gtaaaataat caaaaaatta
    14521 aagggcatat tgattttaac aatatgcctt ttataaatag tctaatttat tctatattat
    14581 cgattatttg gaatgctttt ataacttcag gtaattcttt ttcttcaggc attctaaatc
    14641 ttatgaaatt tttatcaagt ccagtaaaat cacttccaga tataactctt atttttaatt
    14701 tagcaaactc ttgttgtaaa tctatgtcct tgtttttatg ttcaactgtc ataattgata
    14761 cagtatcact agtttcagct atattaaggt ttttccatgg aattaataat tgatttttta
    14821 tatcttttgt tttttctttt aattcttcta taaattgaac atcatctaat aaatttgctg
    14881 caatactacg agatatttca gacacttcgt aaggagtaga aatcttttta atagggctaa
    14941 caagttgttc tggaagaact gcatatcctg ctcttagtcc tgctaaacca aatccttttg
    15001 aaaatgtttt taaagcaatt acattatcat aattatttag aagcttgaca gctgaatttt
    15061 cttttggcat gtattcacca taagcttcat ctaccataac tgctatatca tatttagctg
    15121 cttcctttac tatattttca attgatgata aaggtataat ttgtccagta ggattgtttg
    15181 gattgtctat gtaaattact ttatattctg gatttatttt ttcaataaat tctttttcat
    15241 taaacttgaa attatcctct ttctttaaaa gaacataatc ataagttgca ccatgcattt
    15301 ttatatctgt ctcatattct gagaactgag gtgaatatcc taaaacttta tctccctttt
    15361 caataaatag tctatttaaa aggtaaataa catgtataga accatctgcc aaacaaattc
    15421 tgtcagtatc taatgctata aaatctttcc aataatcaac tatattatct tttaaagcaa
    15481 ttgaatgagg atatcctctt atcatatcaa attttaaagc attaaaagct tctacagctt
    15541 tgtttgagta agacacggta tttatacctt caccacagtc tatctcgaat acatcttctg
    15601 aatgtccaga ttctattgcg taactttttt tcaactgcat ttcaatagct ttgttaattt
    15661 ttagtttcat actttatcac tccttattta gtcaataata aatgttataa aagttgctag
    15721 atttaaaata ttatgaaaat atataatagt aaaa
//
LOCUS       DAEQCW010000086        15428 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.087, whole genome shotgun sequence.
ACCESSION   DAEQCW010000086 DAEQCW010000000
VERSION     DAEQCW010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15428)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15428)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15428
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.087"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            185..1813
                     /gene="aspD"
                     /locus_tag="KRO40_002702"
     CDS             185..1813
                     /gene="aspD"
                     /locus_tag="KRO40_002702"
                     /EC_number="4.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate 4-decarboxylase"
                     /protein_id="HBH2093519.1"
                     /translation="MKNHTYKEIKNIYGKISPFEFKDKLIDIAKYTAKENNRELLDAG
                     RGNPNWTCSTAREAFFTFGHFAITETRSNWDLGHLAGMPQKKGIKERFFKFINENIDM
                     PGAYLARDIINFGINELGFDGDEFVHELADGIIGDNYPLPDRMLPHMEKIVHDYLVQE
                     MKYDISGKYGDVEIFAVEGATAAMCYIFDSLMANELLKKGDTIALMTPIFTPYLEIPN
                     LPRYDFKVVNINANEVDEKGAHTWQYTKKELEKLRDKSIKALFVVNPNNPASIAMDET
                     SCNNLIDVIENYNKDLMIISDDVYGTFVEDFSSLMSKLPYNTVGVYSYSKYFGVTGWR
                     LGTFALHKKNVFDKKINDLTGELKKSVDKRYSDMSLNPSSLSFMERVVADSRLVALNH
                     TAGLSTPQQVQMAFFSAFALIDKVDAYKKLNMSICHRRQKLLFEALELPINENKNNAA
                     YYTQFDIEEWAKLNYGEDLFKFISKTASPVDVLYKLANDYSVVLLSGNGFYGPEWSIR
                     ISLANLYDEAYTKIGKAIREILNGYIVEWQKIKK"
     gene            1934..2929
                     /locus_tag="KRO40_002703"
     CDS             1934..2929
                     /locus_tag="KRO40_002703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HBH2093520.1"
                     /translation="MSIKKKVAIVFTGGTISMTVDDKVGAAIPTLSGEQILSMVTNID
                     KVADVEVFNFDEIPGPHITPYRMMELKNYVNDLLARKDITGVVITHGTDSLEETAYFL
                     DLTIDNIKPVIVTGAMRSSSELGYDGSSNLSASVCTAVSKDAMGKGVLVVLNNEVLLA
                     SEATKTNTLSLNTFKSLTSGPLGIIDCNELVLTRDIVNRTIIDTDKVESKVALFKAYV
                     GENADFIRFAVDSGYKGIVIEAMGRGNIPPQMLSGVEYAREKGLPVVIVSRCHSGRVF
                     DSYGYFGSGRDLKNLGCIFGGDLPGQKARIKLILALGKTDNLDEIKDFFEKGIYC"
     gene            complement(3107..3490)
                     /locus_tag="KRO40_002704"
                     /pseudo
     CDS             complement(3107..3490)
                     /locus_tag="KRO40_002704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     regulatory      3717..3814
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     repeat_region   3955..4513
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=3955..3984
                     /rpt_unit_seq="aatttacattccatatagttaatataaaac"
     gene            complement(4799..4957)
                     /locus_tag="KRO40_002705"
     CDS             complement(4799..4957)
                     /locus_tag="KRO40_002705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093521.1"
                     /translation="MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDL
                     KIRFHKTK"
     gene            complement(5251..6621)
                     /locus_tag="KRO40_002706"
     CDS             complement(5251..6621)
                     /locus_tag="KRO40_002706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp29"
                     /protein_id="HBH2093522.1"
                     /translation="MKLKKLLSLGLVSMFVAGFPISANALDKIDKIQGADKYETAGII
                     ADKQSYTTAILINADSTMADGLSASGLAGATNAPILLTKKNNIPNATLKRVEKAKKVY
                     IIGGESSIDKATETFLKDKGIETRRLQGNDRIKTSYNVAKEINSINKVNKVILTNAFK
                     GEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGIESYAIGGTSSMSDSLVNDTNSTRL
                     GGVDRYDTNKKIVNKFYNGAKEFYIASGTDLVYALVASPMAKNNPIVLVDIGSNKDIL
                     KNAAKVTGIGNLSDKIMLECENTINNISLPSSNKNIICGLKIDFDSNHIIWQDKGSYL
                     ECYDDNLEYYTEKYKDPTVPINIENTSTQNLDVTKLKVYGEANSTLYMGQYAKIKMDF
                     NSFGVLKPGEKCTIYLDIISLDPSRSMTLTFSYVGDKENYKYEQGLASRILFYNPDGE
                     DFFEYK"
     gene            6837..7954
                     /locus_tag="KRO40_002707"
                     /pseudo
     CDS             6837..7954
                     /locus_tag="KRO40_002707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861579.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            complement(8317..8397)
                     /locus_tag="KRO40_002708"
                     /pseudo
     CDS             complement(8317..8397)
                     /locus_tag="KRO40_002708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005541856.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
     gene            complement(8437..9105)
                     /locus_tag="KRO40_002709"
     CDS             complement(8437..9105)
                     /locus_tag="KRO40_002709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH2093523.1"
                     /translation="METVTNNQSGVEIQLSLFEAIKDLLLINPIFLLGIILIGIFLVV
                     IFKKNSDIPKVKTSILSLAMYYYLCLTLSHIVGIPTFSEYIRLSQLGETFFNPNINLI
                     PFSDGFSLSFILNILLFVPLGFLCPLISKTFERLRNTFLIGFGLSLFIETIQLFTLHR
                     ATDIDDLLTNVIGTIIGYFCFKLIAKLRIVKLHSDDDSMEQDYTVCIPIAIIIVALIL
                     GFFS"
     gene            complement(9958..12378)
                     /locus_tag="KRO40_002710"
     CDS             complement(9958..12378)
                     /locus_tag="KRO40_002710"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HBH2093524.1"
                     /translation="MSVYNFKEVESKWQKIWKDNNQYKMDTAQTEKPNYYTLEMFPYP
                     SGKIHMGHVRNYSIGDVVARFKKMEGYNVLHPMGWDSFGLPAENAAIKHGIHPHKWTM
                     ENIEEMKEQLNLLGISYDWDKEVATSTPEYYRFTQEIFLKFLEHGLAYKKKSYVNWCP
                     SCETVLANEQVVQGACERCKATVLKKDLEQWYFKTTEFAEELLNDLDILDGWPEKVKT
                     MQKNWIGKSTGADLVFDIDGTDKSMTVFTTRPDTTYGVTYMVLAPEHELVKELVAGTE
                     YEADVEAFVQKMHTMTEIERTAADVEKEGMFIGRYVINPLNGKKVPLWIANYVLVEYG
                     TGAIMAVPAHDERDRDFAEKYNLDIIDVITEDNKMINSEEFNGLDASEGFEGIIDKLE
                     KEGRGKRTINYRLRDWLVSRQRYWGCPIPVVYCDECGIVPVKKEDLPVLLPTDVEFTG
                     KGESPLTTSKQFMSTTCPHCGKPARREVDTMDTFVDSSWYFLRYVDSNNENEPFSKEL
                     VNRWHPVDQYIGGVEHAIMHLLYARWFVKAFKSMGMVDFNEPFKNLLTQGMVLMDGSK
                     MSKSKGNTVSPMDIIDEYGADTARLFVLFAAPPERDLDWSEQGVDGCFRFLNRVYRLV
                     DELADVVKKDVEFGELNSQDKDMRYTIHSTLKKVTADLSEKFGFNTAISALMELINDM
                     YKYKELDNINEAVIKEGVQTIVTIIAPFAPHLGEELWTMIGKEGSVFDIDWPKYDEKA
                     LVKDEIEVVVQVNGKVRGKLTVNSNISKDEMEKVALEDEKIKGLVEGKTIVKVVAVPK
                     KLVNIVVK"
     gene            complement(12732..13082)
                     /gene="rsfS"
                     /locus_tag="KRO40_002711"
     CDS             complement(12732..13082)
                     /gene="rsfS"
                     /locus_tag="KRO40_002711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HBH2093525.1"
                     /translation="MTVEQMTKIAYDAIEDKLGQDTVIINIGKVSSLCDYFIITTASS
                     QRQVKAIADNVEDELAKLGLEPRGKEGQGTQTWVLLDYGDIMVHVFNEENRGFYNLEK
                     LWKDAPYIDIDTLA"
     gene            complement(13199..13771)
                     /gene="yqeK"
                     /locus_tag="KRO40_002712"
     CDS             complement(13199..13771)
                     /gene="yqeK"
                     /locus_tag="KRO40_002712"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HBH2093526.1"
                     /translation="MNLENINQRLNQMLPVGRLSHSKNVAKCAEKLCEIYGCDKEKAY
                     LAGMIHDCAKYLSDKEIEDYVNKYEIYLDPIEDGNRSLSHSVIGAYICEYEFEVEDED
                     IINAIKYHTTGREDMSLLEKIIYIADLIEEGRKFPVVDTLRELAYGGKLDEALLTSFN
                     NTLMFVINKKEEIHPRTVMARNYLIKEKLL"
     gene            complement(13772..14461)
                     /locus_tag="KRO40_002713"
     CDS             complement(13772..14461)
                     /locus_tag="KRO40_002713"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HBH2093527.1"
                     /translation="MRSENLVKMAELKNTEKLEKFNRHKGKIKIGILGGTFDPIHYAH
                     LATAEFIRDKYDIDKIIFIPSGNPPHKLCITTDKYDRYNMTLLATESNEDFLVSKVEI
                     ERKKRTYTIDTLKYLKKKYKNADIYFITGADAICSVEEWKDVKKNFELATFIAATRPG
                     ISLLRSQETIEKLTKKYNADIITVYVPSLDISSTYIREQLNEGKSIRYLVPENVENYL
                     YENKLYQYGDD"
     gene            14737..15375
                     /gene="recX"
                     /locus_tag="KRO40_002714"
     CDS             14737..15375
                     /gene="recX"
                     /locus_tag="KRO40_002714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HBH2093528.1"
                     /translation="MGIITKIEQQKRNDDRVNIYVDDKFFIAIFKELVYTFNLKKGNE
                     INEEELKPILDDEMYIKAKNKALNILSHADQSEKKLKEKLSSEFDENIIERVIDFLKS
                     YNLVNDSVLAQKIVNTNVNLNKCGKNRIKQNLYNKGINRSTINEAVSELDKDTEFENA
                     MYLAKKRYERVKKEDKKKIYQKISQHLSYKGFDYDIIKRVLNKLLNFDEYDI"
BASE COUNT         5298 a         2449 c         1959 g         5722 t
ORIGIN      
        1 atcatttttt attaaaaggt attttttatt ttaacatata tttaataagg ctaaatagag
       61 ttattatttt aatttcatac tttacttttt ctataaacct attataatta aagtataatc
      121 atttttgcaa cttgtttatt ttattataaa aatgtgaaac ttattacata aggaggaatt
      181 taacatgaaa aatcatactt ataaagaaat caaaaacata tatggaaaaa taagcccttt
      241 tgaatttaag gacaaattaa tagatattgc aaaatacact gcaaaagaaa ataacagaga
      301 attacttgat gcaggtcgtg gaaatccaaa ctggacttgt tcaactgcta gagaagcctt
      361 ttttactttt ggtcatttcg ctattactga aactcgttct aattgggatt taggtcattt
      421 ggctggaatg cctcaaaaaa agggtattaa agaaagattt tttaaattta taaatgaaaa
      481 tatagatatg cctggagcat atttagctag agatattata aactttggta taaatgaact
      541 tggatttgat ggagatgaat ttgttcatga actagctgat ggaattattg gtgataacta
      601 tccacttcca gatagaatgt tacctcatat ggaaaaaata gtacacgatt acctagttca
      661 agaaatgaaa tatgatatat caggtaaata tggtgatgta gaaatttttg ctgttgaagg
      721 tgctacagct gctatgtgct atatatttga ttcattaatg gcaaatgaac ttctaaaaaa
      781 aggagatacc atagccttaa tgactccaat atttacacct tatcttgaaa tacctaacct
      841 tcctcgttac gactttaaag tggtaaatat aaatgctaat gaagttgatg aaaaaggtgc
      901 tcatacatgg caatatacaa aaaaagaatt agagaaactt cgtgacaaat ctattaaagc
      961 tttattcgtt gttaatccta ataatcctgc ttctatagct atggatgaaa catcttgtaa
     1021 taatctaata gatgtaattg aaaattataa taaagattta atgataatat cagatgatgt
     1081 atatggaact tttgtagaag atttttcatc cttaatgtca aaactacctt acaacactgt
     1141 tggagtatat tcttattcaa aatattttgg agttacagga tggagacttg gtacatttgc
     1201 ccttcataag aaaaatgttt ttgataagaa aataaatgat ttaactggag aattaaaaaa
     1261 atcagtagat aagcgttaca gtgatatgag tcttaaccct tctagccttt catttatgga
     1321 aagagttgtt gctgatagca gacttgttgc tctcaaccat actgctggtc tttctactcc
     1381 acagcaagta caaatggcgt ttttctctgc ttttgcattg attgacaaag tagatgccta
     1441 caaaaaactc aatatgagta tctgccatag acgtcaaaaa ctattatttg aagctttaga
     1501 gcttccaatt aatgaaaaca aaaacaatgc tgcatattac actcaatttg atattgaaga
     1561 atgggctaaa ttaaactacg gagaagactt atttaaattt ataagtaaaa ctgcatctcc
     1621 agtagatgtt ctttataaat tagctaatga ctattcagta gttttactta gtggaaatgg
     1681 attctatggt cctgaatggt caattagaat atctctagca aatctatatg atgaagctta
     1741 tactaagata ggaaaagcca taagagagat attaaatggt tatatcgttg aatggcaaaa
     1801 aattaagaaa taattatatt acactgaaat atctaaatta tatgaataaa agagtttatg
     1861 tagaccttaa ctactttttt tgatataatc ctatcggaat tataaatttt atttatgaaa
     1921 ggcagagaat agtatgagta ttaagaaaaa agttgccata gtttttactg gtggaactat
     1981 atctatgaca gtagatgata aagtcggagc agctatacca actttatcag gtgaacaaat
     2041 actatcaatg gttaccaaca ttgataaagt tgcagatgtt gaagttttta attttgatga
     2101 aattccagga cctcacataa caccttatag aatgatggaa ttgaaaaatt atgtaaatga
     2161 tttattagca agaaaagata ttacaggtgt tgtaataaca catggtacag atagtttaga
     2221 ggaaacagct tattttctag accttacaat tgacaacatc aaacctgtaa tagtcacagg
     2281 tgctatgaga agtagttctg aacttggata tgatggttca agtaatttat ctgcatcagt
     2341 ttgtactgca gtatccaaag atgctatggg aaaaggagtc cttgtagttt taaacaatga
     2401 agtattatta gcttctgaag ctactaaaac aaatactctt tctctaaata catttaaatc
     2461 tctaactagt ggcccattag gaataattga ctgcaacgaa cttgtcctta caagagatat
     2521 tgtaaataga acaattatag atactgataa ggtagaatct aaagttgcct tatttaaagc
     2581 atatgtagga gaaaatgctg actttataag atttgctgtt gatagtggtt ataaaggtat
     2641 agttattgag gcaatgggta gaggtaatat tcctcctcaa atgctttctg gagttgaata
     2701 tgctagagaa aaaggacttc ctgtagttat agtttctaga tgtcattcag gtagagtatt
     2761 cgatagttat ggttactttg gttctggtag agatttaaaa aatcttggtt gtatatttgg
     2821 tggggactta ccaggtcaaa aagctagaat aaaacttatc ttagcacttg gaaaaactga
     2881 taaccttgat gaaatcaaag atttctttga aaaaggaatc tattgttaat tctaataact
     2941 tctatttaat tatttattga tatttcaaca tttttaaatc aaaatctaat acttatgtca
     3001 gttaaatgtc agcaaaatat tttatccaca agttttccac aacttatccc caatattatc
     3061 cacaagaaaa aaggtagcac ttatattagt agctaccttt tatttattaa tcttcatctt
     3121 tccagctttt tatccaattt cctatttcta ttattttttc ttcagttatt tcttctccat
     3181 catgcaattt tgaaattaat tctgataatg gattgttatg tagacctcca aaaattcttt
     3241 ttccctctat tttgagatat tctttctctt ttattaatac tctatagtgt acatgtttcc
     3301 caattctctg cgatatgaaa aaaccttttt tagttaatct agctaaaagt gtaattgtag
     3361 ttgtatgctt ccaagcatat gttttttcta tttcatctgc aacatctttt gatattacag
     3421 ttttataacc agtattctat atgtatttca taatttttaa ttctgcatct ggtaattttt
     3481 tattcaacat aatatattcc ttctttcaat ttatgtcact tcctcaaact tatctagctt
     3541 aaattaataa taggagcttt ttatcacaaa aactacaggt aaatttttct atatattcta
     3601 cgtatttagt ctgtttttta agtgtgaaat tacgttcata cctataaatt tattcaattt
     3661 tcaaacaatc ttattgaata ataactaatt ctattgtatt atttagttat agaataaaac
     3721 taaatcggca aaactagaga aatctagtga cgcaaagcta tagagactaa gacttatata
     3781 aatatcttat gagttatgtc agccagttgc caaagagata ttgttctttt tgtttttatg
     3841 aaagtttttt agggggataa taatttatat atttagagat aaaatagata aatgtacaca
     3901 tatattgact gcttatatta gcagttcgta tgattattgt aattttttgg atacaattta
     3961 cattccatat agttaatata aaacaagtgt ttcgaatttc ttttctgaaa ctataccaac
     4021 aatttacatt ccatatagtt aatataaaac gttatatact gaaagcggtg aaactggtta
     4081 cgtagcaatt tacattccat atagttaata taaaacctgt gcgtgtagga gatggtaaca
     4141 caactgttga agaatttaca ttccatatag ttaatataaa acacacatct acatgttttt
     4201 ctatctgagt tcatctctaa tttacattcc atatagttaa tataaaactt tttaatcctt
     4261 cttctgaact cccaaagttt atatcattta cattccatat agttaatata aaacccacga
     4321 aatttaaggt cgatatatca gatttgaaaa aatttacatt ccatatagtt aatataaaac
     4381 aagctaaatg gagcaaccga ccaagtcgct agaaataatt tacattccat atagttaata
     4441 taaaactttt ctattaagtg taagcagaat gcatggaata tgaaatttac attccatata
     4501 gttaatataa aaccccaaaa taaattgagt atttccaatg cctacacata tacaaatctc
     4561 tcaaatttgc agtgaaccat gagtagtgca attgataaca cttatcacaa gtcctcaatg
     4621 ccttatattt caactgttaa gccttaattt cttcaaaaaa tcgaacactg caaaatttct
     4681 atgactttat tatatcataa aaatattatt tttgaatatc tgtaccaatt tgtgatataa
     4741 taaaagcaag aagaactaca atctattttg ctgtagagtg gagttcataa tttagaaatt
     4801 acttagtttt atggaatctg atttttaaat caaattccca accactctta gttgccgctt
     4861 tgagtggttt tttacgcttt ctaaatagtt tgctagctat ataaactatt aagctagcag
     4921 atagacttgc tagtatgcct tgtaaaaaat tatccatgta tattcacctc ccttcttaac
     4981 gtcgggagga taattttttg atacatgaac tccactctat aaattgtaga ttacatcttc
     5041 ttgctaaaaa tattataaca tataattctt acatatttta cctatttatt actttttaca
     5101 ttataataat attcttttaa tcaaaaaaac acctactatt aaagtaaatg tttttaagta
     5161 tttttaattt taaaatccat atagttcata tgaaactaaa tataataact caacatatga
     5221 gcaatatcga gacatttaca tacccactag ttatttatat tcaaaaaaat cttctccatc
     5281 cgggttataa aataatattc tacttgccaa tccttgttca tatttataat tttctttatc
     5341 acctacataa gaaaatgtta atgtcatgct tcttgatgga tctaatgaaa ttatatctaa
     5401 ataaatagta catttttctc ctggctttaa tacaccgaaa ctattaaaat ccatttttat
     5461 tttagcgtat tgccccatat ataatgttga attagcttct ccataaactt ttaattttgt
     5521 tacatctaaa ttttgtgtac ttgtattttc tatatttata ggaactgttg ggtctttata
     5581 tttttcagta taatattcaa ggttatcatc ataacattca agataacttc ctttatcttg
     5641 ccaaattatg tgatttgaat caaaatcaat ctttaatcca catattatat ttttatttga
     5701 agatggaaga ctaatattat tgatggtatt ttcacactct agcataattt tatcacttag
     5761 atttcctatc ccggttactt ttgcagcatt tttaagtata tctttattac ttccaatatc
     5821 aactagtaca ataggattat ttttagccat tggtgaagca actaaagcat aaactaaatc
     5881 agtaccacta gctatataaa attcttttgc gccattatag aacttattta ctattttttt
     5941 attagtatca tatctatcta ctccacccaa tcgagttgaa ttagtatcat ttactaaact
     6001 atcactcatt gatgaagtgc cacctattgc ataactttct ataccagttg tattaaatgg
     6061 aacacttttt ccatcagtta atactatagc tgctttatct ctaactgcta caggtgcagc
     6121 actcatagca tctggctcac ctttgaaagc gttagttaat attactttat ttactttatt
     6181 aatggaattt atttcttttg ctacattata acttgtctta atcctatcat taccttgaag
     6241 ccttctagtc tctattcctt tatcttttag aaaagtttct gttgctttat caatggaact
     6301 ttctcctcct attatgtata cctttttagc tttttctact cttttaagag ttgcattagg
     6361 tatattattc tttttagtca aaaggattgg tgcatttgtt gctcctgcaa gtccactcgc
     6421 acttagccca tcagccattg tactatctgc atttataagt attgcagtag tataactttg
     6481 tttgtcagct atgataccag cagtttcgta tttatctgct ccttgaattt tatcaatttt
     6541 atcaagtgca ttagctgata taggaaaacc agcaacaaac attgacacta accctagtga
     6601 taataatttc tttaatttca caatatctcc cccttttata tatgaaatac tatatatctt
     6661 aataattcta cattaaattt tcttttcctc ctttaacgat atttatcttc ctgttaattt
     6721 aagtgtatac aaatacgtgt tataatgtaa ctgtaaagaa ttaaaaagat aatgacataa
     6781 ttagagtagt acaactgttc ttttataaaa ctaacttata aagggagcgt acatatatga
     6841 atatcaaatc agcttttata agaaaaagag gggaaaaatt ctatgtatat gtggagtaca
     6901 tagaggaaac aactggcaag ataaaacaga aaagttatgg aagttatgaa aagaaaaagg
     6961 atgctgaaaa acatttaatt gaaataaaat ctactataaa caataataag tttgttgctc
     7021 caaaagatat gacatttgta gaaagatgtt ataaatacat ggacatgaat aaaaataatt
     7081 ggtctccata tactgttaca aatacaaaat cttgggttaa aaattacata gaacctcttt
     7141 ttaagaatct aaaactcaca gaagtaaatc ctagttcagt acaagctttt gtaaattata
     7201 actttaataa ttctaccttt actagtgcta aagtaaggta tagctttcta agttctgtaa
     7261 taagggaagc atatagatta agagaaatac aagaaaattc atgtgatttt ataaaacttc
     7321 cttctaaaga aaaatattct acaaatgaaa tatacaatag aaaagaagta ttattgctaa
     7381 tagaaaagtt acttagtaat aatatagaaa tacctattct tttaatgtta cttctaggtt
     7441 taagaatggg agaagctact gggcttaggt ggtcagatgt tgacttagat aacaatctga
     7501 taaatgttaa tcaaattctt gtctattcta atggcaaaat atcttttaaa gagccaaaaa
     7561 caccaaaatc aaaaagagct ttatcagctc caaaagaatt aattgaaaaa ttgaaaatta
     7621 aaaaactaag acaaagcaaa ttaaaattgt aaggtatcct ggaaaacaga aataatttag
     7681 tttgtctaaa caccaattta aatccgtttc taccttcttc actaagaaaa acgtttcaca
     7741 attttacaaa aaaaataatt taaaaaagat tagaatacat gatttaagat atacaagtgc
     7801 cactctgctg cttttagggg gaactaatat gaaagttgtt tctgaaagat tgggtcatac
     7861 agatataaaa ataactatga atagatattc tcatgtactt aaagaaatgg acaaagaagc
     7921 ttccgacaat ctaagcgaac ttctatttaa atagtaaaaa ctgactgtca gttaaatgtc
     7981 agttaaacct aaaaaaatag gttttgtcag ttgattatca gtcaattatt ttataatagt
     8041 ttcacttaaa aacgtctata tctacacatt ttactatttg tttatgctta ttaatatcta
     8101 tctgttatta ttaattctaa tagcttctat ttaattattt agttcagttt acaggaaact
     8161 acacacaaac cataaaatag gatgttgaca atataacaga tagtatgctc ctgtaaaagg
     8221 taacgtacta tctgttatgt tgtctggatt tccaaatggt taccctttgg cacacaactt
     8281 tgctatctcc ttggtaaact aaaagtttgt aatctaaaat cctaatccat ctctataaaa
     8341 tttaattgac ttctccatac tttttacacc taaacatata aaagtaattt tattcactta
     8401 atgacctcca taattcccaa attagctatt tggaacttaa ctaaaaaatc ctaatataag
     8461 ggcaactatt ataatggcaa tcggaataca tactgtgtaa tcctgttcca tagagtcatc
     8521 atctgaatgt agttttacaa ttcgcaattt agcaatcagt ttgaagcaga aatagcctat
     8581 tattgttcca attacattcg tgagtaagtc gtctatatcg gttgctctgt gtaacgtaaa
     8641 aagctgaata gtttcgataa aaagagataa tccaaaacca atcaagaatg tatttctcaa
     8701 acgttcaaag gttttgctga taagcggaca taaaaaacct aatgggacaa aaagtaaaat
     8761 attcaaaata aaactcaaac taaatccatc actaaaagga ataagattta tgtttggatt
     8821 aaagaacgtt tcccctaact gtgacagtct tatatattca ctgaatgtag ggataccaac
     8881 aatatgcgat agtgttaaac ataagtagta atacattgcc agtgataaaa tagatgtttt
     8941 tacctttgga atatcactat ttttcttgaa tattacaact aagaaaatac caatcaagat
     9001 aattcccaac aagaaaatag gattaattaa caataaatct ttgatagctt caaacagact
     9061 gagttgaatt tctacacctg attgattatt tgttacagtc tccatttgta catacctcct
     9121 cataacattt caattatttc taaaacacaa aatagaagat aaatcttaaa atcatcctat
     9181 caaaattttt aaatttgcct ttatcagttt ataccaccag ttaattcctg tcttacttct
     9241 gtatggtatt cttgggattc tttcatcaaa ttagacaaaa aatggttacc atatcaataa
     9301 actggttacg ctccatatct cccgaagcaa ccatcccctg agaataaatc cgtatcagga
     9361 atctccacat ctactgcacc tatcacaagt tatttgataa catcctcaga caatcccaac
     9421 ttggatatat cgacaacacc cattagaata ccactgctga ccatacttgt tttcctgctg
     9481 ataattttaa tcaactggga agttgaaacg ctatcttttt tacaagttcc tttttagaaa
     9541 catggtagct attatatgaa tctgaatttc gttgtctggg tgtttcatat aaagcataga
     9601 tacgcacctt ttttgcctgt tttcattata tagaaaaaaa tttcaaaata caataattat
     9661 atttttttcg tttaagctta gagcagttcc ttgatgaaca acactttgga aactgaatga
     9721 tttacatacc acttaataca ttaactcgat ttaacattaa ttataataat atttaaaaca
     9781 acaactaggg tatataagaa tgaacttttt agttctttaa tcattttttt gtataaaatc
     9841 aaatctattt ttataatttc aacaaattta taatttcaac aatgaaaaaa ggcttatctc
     9901 tattttgaga cagcctcgtt tattttataa atttatattt ttgttcatat ttttgagtta
     9961 tttaacaact atatttacta gttttttagg tacagctaca actttaacta tagttttacc
    10021 ttcaactaat ccttttattt tttcatcttc taaagctacc ttttccatct catctttaga
    10081 tatatttgag ttaacagtta attttcctct aacttttcca ttaacttgta caacaacttc
    10141 tatttcatct tttactaaag ctttttcgtc atatttaggc cagtctatgt caaatacact
    10201 tccttcttta cctatcatag tccatagttc ttcacctaaa tgaggggcaa atggtgcaat
    10261 tatagttact atagtttgta caccttcttt tataactgct tcgtttatat tatctaactc
    10321 tttatattta tacatatcat ttattaattc cataagagct gatatagcag tattaaatcc
    10381 gaatttttca cttaaatcag cagtaacttt tttaagtgta gagtgtatag tatatctcat
    10441 atccttatct tgggaattta attctccaaa ctctacatcc tttttaacca catctgctaa
    10501 ctcgtcaacc aatctataaa ccctatttaa gaatctaaag catccatcaa caccttgctc
    10561 tgaccagtcc aaatctcttt ctggtggtgc tgcaaataat acgaaaagtc ttgcagtatc
    10621 tgctccatac tcatctatta tatccatagg agatactgta ttccctttag acttactcat
    10681 tttagaacca tccataagta ccattccttg agtaagtaag tttttaaatg gctcattgaa
    10741 gtctaccatt cccatactct taaatgcctt tacaaaccat cttgcataaa gtaaatgcat
    10801 tatagcatgt tctactccac ctatatattg gtctactgga tgccatctat taactaattc
    10861 cttactaaat ggttcatttt cattattgct atccacatat cttaagaaat accaagaaga
    10921 atcaacgaat gtatccatag tatcaacttc ccttctagct ggttttccac agtgaggaca
    10981 agttgttgac ataaattgct ttgaagtcgt aagtggagat tccccttttc cagtaaattc
    11041 aacatctgtt ggtaaaagaa ctggtaaatc ttccttttta actggaacta ttccacattc
    11101 atcacaataa accacaggta taggacaacc ccagtatctt tgtcttgaaa ctaaccagtc
    11161 tctaagtcta taattaattg ttctctttcc tctaccttct ttttctaact tatcgattat
    11221 tccttcaaat ccttctgaag catctaatcc attaaattct tctgaattta tcattttgtt
    11281 atcttctgtt attacatcaa ttatgtctaa attatatttt tcagcaaaat ctctatctct
    11341 ttcatcatgt gctggaactg ccattatagc acctgttcca tactcaacta atacatagtt
    11401 agctatccat agaggaactt tcttgccatt taaaggattt ataacatatc tacctataaa
    11461 cattccttct ttttctacat cagctgctgt tctttctatt tctgtcatag tatgcatttt
    11521 ttgaacaaaa gcttcaacat ctgcttcata ttcagtccct gcaaccaatt ctttaactaa
    11581 ttcatgctct ggagcaagta ccatataagt aactccataa gttgtgtctg gtctagttgt
    11641 aaatactgtc atagatttat cagttccatc tatatcaaaa actaaatctg ctcctgtact
    11701 tttacctatc caattttttt gcattgtttt aactttttct ggccatccat ctaatatatc
    11761 taagtcatta agtaattctt ctgcaaattc agtagtctta aaataccatt gttctaaatc
    11821 tttctttaat actgttgctt tacatctctc acatgctcct tgaacaactt gctcatttgc
    11881 aagaacagtc tcacaagaag gacaccagtt aacatatgat tttttcttat atgcaagccc
    11941 atgctctaaa aacttcaaaa atatttcttg tgtaaatcta tagtattctg gcgttgaagt
    12001 tgcaacttct ttatcccaat cataactaat acctaataaa tttaattgct ctttcatttc
    12061 ttctatattt tccattgtcc atttatgtgg atgtattcca tgttttatag ctgcattttc
    12121 agctggtaat ccaaaagaat cccatcccat tggatgaagt acattatatc cttccatttt
    12181 tttgaatctt gcgacaacat cacctataga ataatttcta acatgtccca tgtgtatttt
    12241 tccagatgga taagggaaca tttctaatgt gtaataatta ggtttttcag tttgtgcagt
    12301 atccatttta tactgattat tatctttcca gattttttgc catttcgatt ctacttcttt
    12361 aaaattatat acgctcatat tttgcctcct atttttaatt gtgtataact accttattta
    12421 gtattattta cttataattt ccaaataatt ctttgaaaat aaaaaatcct cgtcactaaa
    12481 cttacgttta gggacgagga taaatcttcg cggtaccacc ctaattagcc tactacatat
    12541 atagactctc ttagatagct tttaatccag ccatggagaa tagattttaa tctagtaagt
    12601 tcaaagttat ataatattag ttctcacctt ccactaactc tctgaaaaaa tataatcttt
    12661 tactgctcta gtctattcaa tttaatataa tttttgaaat tttctaatta taataacata
    12721 tattatcatg tttatgctaa tgtgtcaata tctatataag gtgcatcttt ccataatttt
    12781 tctaaattat aaaaccctct attttcctca ttaaatacat gaaccattat gtctccataa
    12841 tcaaggagta cccaagtttg agttccttgt ccttctttac ctcttggctc taatcctagt
    12901 tttgctaatt catcttccac attgtcagca atagctttta cctgtctctg agaagatgct
    12961 gtagtaataa taaaataatc acacaaacta gaaacttttc ctatatttat tataactgta
    13021 tcttgaccca gtttatcttc tatggcatca tatgctattt ttgtcatttg ttccactgtc
    13081 atataaaaat tcctcacttt cctaattaaa atacacttag ttattgtaac atattaatac
    13141 gattttgtaa catagtcaaa tttaaattta ttaatatgtt tgcctttata tagctttttt
    13201 ataataactt ttctttaatt agatagtttc ttgccataac tgttcttgga tgtatctctt
    13261 cttttttatt gatgacaaac attaaagtat tattaaaaga agttaaaagt gcttcatcaa
    13321 gcttccctcc atatgctaat tctcttaatg tatctacaac tgggaatttt cttccttctt
    13381 caattaaatc agctatgtaa attatttttt ctaaaagaga catgtcctct ctccctgttg
    13441 tatgatattt gattgcattt ataatatctt catcttccac ttcaaattca tactcgcata
    13501 tgtacgcccc aattacacta tgagacaagg aacgatttcc atcctctatt gggtctaaat
    13561 atatttcata cttatttaca taatcctcta tttccttgtc acttaaatac tttgcacaat
    13621 catgaatcat tcctgctaag taagcttttt ctttgtcaca tccataaatc tcacataatt
    13681 tttcagcaca ttttgcaaca ttttttgaat ggctaagcct ccccactggt agcatttgat
    13741 ttagtctttg gttaatattt tctaagttca tttaatcatc tccatattga tatagtttat
    13801 tttcatataa ataattttct acattttcgg gtactaagta acgtattgac ttgccttcat
    13861 ttagctgttc ccttatatat gtggacgata tatccagtga tggaacataa actgttataa
    13921 tgtcagcatt atacttctta gttagttttt ctatagtctc ttgtgacctt aacaaactaa
    13981 ttcctggtct agttgcggct ataaaagtag ctaactcaaa gtttttcttt acatctttcc
    14041 actcttcaac actacaaatt gcatctgcac ctgttataaa ataaatgtct gcatttttgt
    14101 attttttctt taagtatttt aatgtatcta ttgtataagt ccttttcttt ctttcgattt
    14161 ctacttttga aactaaaaaa tcttcgttgc tttcagttgc tagaagtgtc atattatatc
    14221 tatcatactt atctgtagtg atacataatt tatgtggtgg atttcctgat ggtataaaga
    14281 ttattttgtc aatgtcatac ttgtctctaa taaattctgc tgttgctaaa tgagcatagt
    14341 gtatagggtc aaaagtacct cccaatatac ctattttgat tttgccttta tggcgattaa
    14401 atttctctag tttttcagta tttttcaact ctgccatctt aactagattt tcacttctca
    14461 tattttgtct ccttttaatg ttataatact attgtaccat tattttttat ttcttaaagc
    14521 ttataatttg tttttttggg tatataatta tatttatatg ctaaaaaaca ctttaaaaaa
    14581 taattattta acatgattct gctttacttt ttaataaaaa taacttttta ctattttgtc
    14641 ttaattttga taaaatataa catacaaata taagtttttt gttaaatttt attagttgct
    14701 tttgttaata taattacata taaaaaagga ggacttatgg gtataattac aaaaatagaa
    14761 caacaaaaaa gaaatgatga tagagttaat atttatgtag atgataaatt ttttattgct
    14821 atatttaaag aactggttta tacatttaat ttaaaaaaag ggaatgaaat aaatgaagaa
    14881 gaattaaaac ctattttaga tgatgaaatg tatataaaag ctaaaaataa agcattaaat
    14941 attttatctc atgctgacca atctgaaaaa aaattaaaag aaaaactatc atcagaattt
    15001 gatgaaaata taattgagag ggtcatagat tttcttaaaa gttataatct cgtaaatgac
    15061 agtgtattag ctcaaaaaat tgttaacaca aatgttaacc taaataaatg tggcaaaaac
    15121 agaattaagc agaatttata taataaaggt atcaatagaa gtacaatcaa tgaagcagta
    15181 tctgaattag acaaggacac tgaatttgaa aatgctatgt atctagcaaa aaaaaggtat
    15241 gaaagagtaa agaaagaaga taaaaagaaa atatatcaaa aaatttctca acatctttcc
    15301 tataaaggct ttgattatga tattattaaa agagttttaa acaaactttt aaattttgat
    15361 gaatacgata tataagtata aatactaggg aggtaaatta tgaaattaat cattggtggc
    15421 ttaagctt
//
LOCUS       DAEQCW010000087        15299 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.088, whole genome shotgun sequence.
ACCESSION   DAEQCW010000087 DAEQCW010000000
VERSION     DAEQCW010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15299)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15299)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15299
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.088"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..191)
                     /locus_tag="KRO40_002715"
     CDS             complement(<1..191)
                     /locus_tag="KRO40_002715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009274602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2093529.1"
                     /translation="MKKIKSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFII
                     ILFGDMPPLSMIEGAFLKY"
     gene            complement(312..815)
                     /locus_tag="KRO40_002716"
     CDS             complement(312..815)
                     /locus_tag="KRO40_002716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH2093530.1"
                     /translation="MIDDMAVYIANLGKYNEGYLVGAWFSFPIDEEDVKEKIGLNEQY
                     EEYAVHDTDNFPIDIGEYVSIEELNEMYEMIEELPDYIVECLDEFISHYGTLEEVVEH
                     KDDIYYYPDCETMTDVAYYYIDELQALGDIPPSLQNYIDYEAYGRDLDMGGCFIETSR
                     GMCEIPY"
     gene            complement(833..1336)
                     /locus_tag="KRO40_002717"
     CDS             complement(833..1336)
                     /locus_tag="KRO40_002717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004843359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBH2093531.1"
                     /translation="MQETRVLVETKRTTDEETTSYWFDLPIEVAEFEEKLGVGAESGE
                     YRIIEKVLPYADEVHEHTSVYQLNKLDFMYRQLSSDMQEEYVSLLMVFENLEALYICR
                     NVITVYPDCKSMIDVARQKLMNDPTFKHLSEDCQEYYFNFEAYASHLQEHGKFLVTEH
                     GIFELPE"
     gene            complement(1255..1551)
                     /locus_tag="KRO40_002718"
     CDS             complement(1255..1551)
                     /locus_tag="KRO40_002718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005339688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HBH2093532.1"
                     /translation="MNDIFKNMQAKIGCEYLSDLPSYKRKVWHEMKQLNLADYEEKQL
                     EDFSKYVFGMSYQTLKDVMKQQIGREEQCRKQGYWWKRKEQLTKKQHHTGSTCR"
     gene            complement(1658..2035)
                     /locus_tag="KRO40_002719"
     CDS             complement(1658..2035)
                     /locus_tag="KRO40_002719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093533.1"
                     /translation="MDYKVDDKNLDASMFISFVNQVWQGDYDMEQTRQALSKTLNITA
                     YDNKKLVGCLRILSDGYYFGTITELLVLPQYQKQGIGSKLLQLAKDNTPTMLYFGSQP
                     EAEKFYEKNGCQKSLQSYMINKG"
     gene            complement(2116..2277)
                     /locus_tag="KRO40_002720"
     CDS             complement(2116..2277)
                     /locus_tag="KRO40_002720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093534.1"
                     /translation="MAIVVIGIYLGFKREFSKLIGFLVVALVAVGLVFNAGGVKDVLL
                     ELFNKIIGA"
     gene            complement(2444..4354)
                     /gene="ltrA"
                     /locus_tag="KRO40_002721"
     CDS             complement(2444..4354)
                     /gene="ltrA"
                     /locus_tag="KRO40_002721"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HBH2093535.1"
                     /translation="MPKNKNETLCVEDLRHAEYYEMQNTFDDLYAKSKNGDIFTHLMD
                     IILSRENILLAYRNIKANAGSKTAGTDGTIIKDIGKLPAETVVKKVRYIVAGTPHGYR
                     PKPVRRKEIPKPNGKTRPLGIPCMWDRLIQQCIKQVLEPICEAKFSENSYGFRPNRSV
                     ENAIKATYNRLQISQLHYVIEFDIKGFFDNVNHSKLIKQIWAMGIRDKHLIFILKRIL
                     KAPIKMPDGTITYPEKGTPQGGIISPLLANIVLNELDHWVESQWHENPVTKNYVVHIN
                     KSGSPCKSNAYKEMKKTKLKEMYMVRYADDFRVFCRYKESAEKTKIAITQWIEQRLKL
                     EVSQEKTRIVNVRKRYSDFLGFKIKMIPRRKKLVVKSHISDKQFKTQKDKLVSQAKKI
                     ASPSKGKTELEEIRLYNSMVLGMQNYYQIATNVNLDCMKLNRAVMAIFTNRLGASKKG
                     RLRKTGRQLTTKEATRYGKSKMLRYVAGEGEPIFPVGYIQHRKPMAKVYSANCYTPEG
                     RKFIHTNLSVDKLLMYQLMKLSLENRTIEYADNRISLFSAQHGKCAITLEEFQQANEI
                     HCHHIVPTRAGGNDDYKNLILVKEAVHRLIHAKTEETIQKYIALLKLNKVQLIRLNKY
                     RVLAGNQELNLI"
     gene            complement(5096..5230)
                     /locus_tag="KRO40_002722"
     CDS             complement(5096..5230)
                     /locus_tag="KRO40_002722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017143882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3789 domain-containing protein"
                     /protein_id="HBH2093536.1"
                     /translation="MWELLKDFLLVSLGMGIGVVLMCILTVGKEADRCMEEIKEREEH
                     "
     gene            complement(5237..6436)
                     /locus_tag="KRO40_002723"
     CDS             complement(5237..6436)
                     /locus_tag="KRO40_002723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002319753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBH2093537.1"
                     /translation="MNETDFLTALKAKRCAYSVSQTRLAIMANISREHLSRIEAGKVT
                     LTEDMKHTLLEAVEKFNPDNPMFLLFDYVRIRFPTMDIKHIIKNILKLNIDYMLHEDY
                     GHYKYTEHYHIGDVFVYVSQDEEKGVLLELKGKGCRQFESYLLAQERNWYDFFTDALV
                     EGGVMKRLDLAINDRTGLLDIPELIQKCENEECISKFRSFKSYGSGELVKHNETDKYG
                     MGHTLYIGSFSSEVYFCCYEKNYEQYAKLGIPIEEVPIKNRFEIRLKNERAYYAVVEL
                     LTHYDAEQTAFSIINQYIRFADKEPDKRKSDWKTNVRWAWFIGEGRPPVKLTTKPKPY
                     TLERTLNWLQRQVAPTLKMLKQIDKDNQTEYLETIEKQAKLTERHHQIIKQQTATVEE
                     MVAKVKE"
     gene            complement(6638..8032)
                     /locus_tag="KRO40_002724"
     CDS             complement(6638..8032)
                     /locus_tag="KRO40_002724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008787614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2093538.1"
                     /translation="MRIIWNKGHRIRASDKNLVYRFSLGTLLIVFVVVLLLLNMKQLM
                     RTDWEHFSLLDNSFTLSLYNFITLLIATGVCALVAFLYYRFCYDNFKKLLHRQKLARM
                     ILENKWYEADTVQDSGFFTDLQSRSREKIVWFPKIYYQMEKGLLHIRCEITLGKYQDQ
                     LLRLEDKLESGLYCELTDKTLHDGYIKYILLYDMIANRITIDEVRAENGCLRLMKNLV
                     WEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNADLADLGTVMGNVY
                     HTKEEMIDCVNAFYEGMVQRSEEMKQHPNYKTGENYAYLSLPPCFLIFDEYVAFFEML
                     GTKESVSLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISEL
                     GYGMLFGSDVKKQFFQKRIKGRGYCDVGTSIISEFYTPLVPKGYDFLQTIGSLAYARQ
                     DGTATCEAKGDGTD"
     gene            complement(8143..8454)
                     /locus_tag="KRO40_002725"
                     /pseudo
     CDS             complement(8143..8454)
                     /locus_tag="KRO40_002725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896960.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YcxB family protein"
     gene            complement(8482..9024)
                     /locus_tag="KRO40_002726"
     CDS             complement(8482..9024)
                     /locus_tag="KRO40_002726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH2093539.1"
                     /translation="MKGFERKNQLFSLCGLNCGLCPMLLGNYCGGCGNGNQSCRIAKC
                     SLEHGQIEYCYECKQYPCEKYQHIDDYDSFITHKQRKADLERAKNIGIEQYNLEQQEK
                     TQILSYLLSNYNDGRRKTFFCVAVNLLELSELQEAMKQIQSNDELTLLPFKAQCLYVV
                     EVFQKIAERRNIKLKLFKKK"
     gene            complement(9085..9687)
                     /locus_tag="KRO40_002727"
     CDS             complement(9085..9687)
                     /locus_tag="KRO40_002727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2093540.1"
                     /translation="MDKVVIYIHGKGGNAEESSHYKPLFSDCDVVGLNYTAQYPWEAK
                     EEFPSLFDLICKHYKSVQIVANSIGAYFAMNALSDKQIEKAYFISPIVNMEKLIADMM
                     YWANVTEDELRDKKEIKTTFGETLSWEYLCYVKENPTTWKIPTNILFGEKDNLTSYAT
                     ISEFTKQTNATLTVMRNGEHWFHTEEQMKFLDEWINKSAR"
     gene            complement(9742..10155)
                     /locus_tag="KRO40_002728"
     CDS             complement(9742..10155)
                     /locus_tag="KRO40_002728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH2093541.1"
                     /translation="MLDKIPNAEEMTALVGQSLYAIWNKLCALIDEKYDMECLWNKGG
                     KAWTYEYKYRRGGKTLCALYARENCVGFMIILGKDERLKFDTDRNSYSKEVQKIYDET
                     KTYHDGKWLMFEPTDTILFNDFVKLLGIKRKPNRK"
     gene            complement(10219..10677)
                     /locus_tag="KRO40_002729"
     CDS             complement(10219..10677)
                     /locus_tag="KRO40_002729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2093542.1"
                     /translation="MKFKNPMLVVTDIDKSVEFYKKVFGLRVIMDFGANKTLTGGLAL
                     QTSETYKEFIGTSDISFGGKNFEVYFEEDDFDKFADRLKEYDIEYVHPIIEHSWGQRV
                     VRFYDPDKHIIEVGENMKIVCKRFLNSGMTPEQVAERMDVPMKFINACMR"
     gene            complement(10758..11171)
                     /locus_tag="KRO40_002730"
     CDS             complement(10758..11171)
                     /locus_tag="KRO40_002730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH2093543.1"
                     /translation="MRLANGIVLDNEKTFGVLKFSALRHEVRVENEDGTTSDEIKRRT
                     YDLKCSVQERMIQVSIPADVPVKDFPYNAEVELINPVADTVANANFRGADVDWYIKAD
                     DIILKNKGNQPAGNPQNNNPQNLAPQGQQKNKLAN"
     gene            complement(11186..11509)
                     /locus_tag="KRO40_002731"
     CDS             complement(11186..11509)
                     /locus_tag="KRO40_002731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HBH2093544.1"
                     /translation="MELKYIVPNVAQTFGNLEFAGENKVDQQHINGRYTPVSRSYNLY
                     SDIQRADDIIVVLPAKAGEKHFKPEQKVKLINPRITAEGYNVKGRGFTNYILMADDML
                     PAESK"
     gene            complement(11731..14778)
                     /locus_tag="KRO40_002732"
     CDS             complement(11731..14778)
                     /locus_tag="KRO40_002732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBH2093545.1"
                     /translation="MKKILKRLCTGFLAFATVVTALPSSTVHASNTQYWTESKERVGI
                     VEQVMNDGSISSTFNEGHLTVEGKDAYCIDINTAFKNGYKTRTDASSRMSADRISDVA
                     LSIEYVKQYTDSHSGISSKHAYLLKQLVVWQRLSVQLDWQCDNVRASYDEIPKAVQDE
                     VFAGAKAFVKENKGRYDCGGYIYSGEGQELGQFWAKLAVGNAKLQKTSTNANITDGNG
                     IYSIAGATYGVYSDKDCTKQLATLTTDTSGNTEAVEVRATTVYIKELSAPAGFKIDKT
                     VYSLSVEAGKTATLKVSDTPKVTDTLIELFKIDMETQKSNSQGNASLEGAEFTWNFYA
                     GYYNKNNLPAQPTRTWVTKTIAEKDSDGAIHYITRLANAYKVSGDSFYMQDGKNVLPL
                     GTLTVEETKSPSGYLLEGAYMQADGSEEQIKEMYLTQITEDGDLAVLSGSNQYHVSDK
                     VIRGGVKIQKRDLETKDTKAQGGATLKNTAFEIISLNENAVLVESKLYKKNEVLKTIH
                     TDIEGIASTSADLLPYGKYRLSEQKPPEGYLTDGAKPIDFEITENGKIVDLTDEAHSI
                     YNQIKRGDIEGVKIGAGSHKRLADVPFRITSKTTGESHVVVTDDNGQFSTASDWASHK
                     HNTNAGKTSEDGVWFGTSEPDDSKGALIYDTYIIEELRCESNKGFKLIPPFEIVISRN
                     KVVVDLGTLTDEYEKEITIHTTATSKDGEKTILAGNDVTIIDTVKLDGLVKGTKYQLK
                     GWQMLKKENAELLVGDKRVESDYTFVADDEAMKVEIAYTFNASALGGKNLVTFEELYD
                     LSNPEEPVKVAEHKDIEDDGQTVLITERIIKIHTTATDKDGKKEIEAGKDVTIVDTVK
                     LEGLEVGTKYQLVGWQMLKEENAELIINDKKVENDYTFTSDSETMEVKIAFTFDASSL
                     GGKQFVTFEELYDLSNPDKPIKVTEHKDIEDDGQTVTIKEVPETPTPEEPEKPTTPDT
                     PTKTDSPKTGDNTNILAFAIMMFVSAGGLAGTYFFKRRKMKKS"
BASE COUNT         4096 a         3238 c         2598 g         5367 t
ORIGIN      
        1 aagtatttga gaaatgctcc ctcaatcatg gaaagtgggg gcatatcccc aaacagaatg
       61 atgataaatt ctgtaattac aaaccatgta atctgtgtaa aggtaacggg aaagggtaag
      121 ttaaagtcat tgattgcata caagactttt tccacgttcc agatacccgt gtagctttta
      181 atctttttca agttctttca gctcctttcg taagttctta aaaagagaaa aggacagcca
      241 tgtttcagac tgtcccttaa aagagaaata cgctgtcagt agcaacaatg cttgtcgctg
      301 atcttccagc gttaataagg tatctcgcac atacctcggc ttgtttcaat aaagcaaccg
      361 cccatatcca aatctcgacc gtaggcttca tagtcaatgt agttctgtaa gctgggtgga
      421 atgtcgccaa gtgcctgcaa ttcgtctatg tagtagtagg caacgtctgt catggtttca
      481 cagtctggat aataataaat atcgtccttg tgttccacga cttcttccag cgtcccgtag
      541 tggctgataa attcgtccag acactctacg atatagtcgg gaagttcctc tatcatttca
      601 tacatctcat tgagttcttc aatggaaaca tattccccta tgtcgatagg gaagttgtca
      661 gtatcatgga cagcgtattc ctcatattgt tcattcaaac cgattttttc tttcacatct
      721 tcctcgtcaa tagggaaaga gaaccacgca ccgactaaat atccctcatt gtatttgcca
      781 agattagcaa tataaaccgc catatcatca atcataagcc ccacctcact tcctactctg
      841 gcagttcaaa gataccgtgt tctgttacta aaaatttccc gtgttcctgc aagtgagaag
      901 cgtaggcttc aaaattgaaa tagtattctt gacagtcctc agataaatgt ttgaacgtcg
      961 ggtcgttcat cagcttttgc cttgcaacat ctatcatact tttacagtcg ggataaacgg
     1021 taattacatt tctgcaaata taaagtgctt ctaaattctc aaacaccata agtagtgata
     1081 catattcttc ctgcatatcg cttgaaagct ggcggtacat aaaatctaat ttgttgagct
     1141 ggtacacgct tgtatgttcg tggacttcat cagcataagg caataccttt tcgataatac
     1201 ggtattcccc actttctgca ccgacaccta atttttcctc aaattcggca acctctatcg
     1261 gcaggtcgaa ccagtatgat gttgtttctt cgtcagttgt tcttttcgtt tccaccagta
     1321 cccttgtttc ctgcattgtt cctcacgtcc tatctgttgt ttcatcacat cttttaaggt
     1381 ctggtatgac ataccaaaca catactttga aaaatcttct aactgtttct cttcataatc
     1441 ggcaaggttc agttgtttca tttcatgcca caccttacgt ttgtaagagg gcaggtcaga
     1501 aagatattca cagccgattt ttgcctgcat attcttaaaa atatcgttca ttacatcact
     1561 ccaatctaat ttttaggtaa gaaaaaagca gtcaatccta agactaactg ctttgtgtat
     1621 atggatataa aattgtcaag ctggaagtta tctcttatta tcccttattt atcatgtaag
     1681 attgtaagct tttttgacag ccgttctttt cataaaactt ctctgcttct ggttgagaac
     1741 cgaaatataa cattgtaggt gtattgtctt ttgcaagttg aagaagttta cttccaatac
     1801 cctgtttttg atattgagga agaacaagta gctctgtaat tgttccaaaa tagtaaccat
     1861 cggaaagaat acgcaaacac cctactaact ttttattgtc ataggctgtt atgtttagtg
     1921 ttttagataa tgcttgcctt gtttgttcca tatcataatc gccctgccat acttgattga
     1981 caaaagaaat aaacattgat gcatcaaggt ttttatcatc tactttgtag tccattattg
     2041 ttcctccaac ttctaatttg ttgctttctt catatccata tcataccatt tctacactca
     2101 cactacaata aaattttatg caccgataat cttattgaac agttctaaca atacgtcttt
     2161 cacaccacca gcgttgaata ccaagccaac ggcaacaaga gcaactacca agaagccgat
     2221 aagttttgaa aactcacgct taaaacctaa gtagatacca attaccacaa tcgccataag
     2281 cactaaactc tgtgcgttgc ttaaaaacca agtgtatatg gataggtaag ttcctgatat
     2341 tataaatatc tcaaactttt ccccccattc acacggagcg tgcgactttc accgcactcc
     2401 gcgttccatc gtgtttatat tgaaaagtat ttatgtagta gacctatatc aagtttaatt
     2461 cttgattgcc agctaatact ctatatttat ttagtcttat gagctggact ttatttagtt
     2521 tcaatagagc tatatatttt tgtattgttt cttctgtttt tgcgtgtatt agacgatgta
     2581 ccgcctcttt taccaaaata agatttttat aatcgtcatt accaccagcc ctagttggta
     2641 caatatgatg acagtgtatt tcattagctt gttgaaattc ttccagagtt atagcacatt
     2701 ttccatgttg ggcagaaaat agcgaaattc gattgtctgc gtattctatt gtgcgatttt
     2761 ccaaagataa tttcatcaac tgatacatca gtaatttatc aacacttaga ttggtatgga
     2821 taaattttct tccctctgga gtatagcagt ttgctgaata cacttttgcc attggttttc
     2881 tgtgttggat atatccaaca gggaatatag gttcgccctc gccagcaaca tatcgaagca
     2941 ttttagattt accatatctt gttgcttctt ttgttgtaag ttgtctgcct gtttttctca
     3001 atctgccctt tttgcttgca cctaatctgt tagtgaagat agccattaca gctctattaa
     3061 gtttcataca atccagattt acatttgttg caatctgata ataattttgc atacctaata
     3121 ccattgaatt ataaagtctt atttcctcta attctgtttt tccctttgag ggagaagcaa
     3181 ttttctttgc ctgtgatacc agcttgtctt tttgggtctt gaattgttta tcacttatat
     3241 gtgatttaac aactaacttc tttcttctcg gtatcatttt aatcttgaaa ccaagaaagt
     3301 cggagtatct ttttctaaca tttacaattc ttgttttttc ttgtgatact tccaatttta
     3361 gtcgttgctc gatccattga gtaattgcta ttttggtttt ttcagcactt tctttgtagc
     3421 gacagaaaac tctaaaatca tctgcataac gaaccatata catttccttt aactttgttt
     3481 tcttcatttc tttgtaagcg ttgcttttac atgggctacc gcttttattg atatgaacca
     3541 catagttttt tgtaacagga ttttcatgcc attgactttc tacccaatgg tctaactcat
     3601 taagaacaat gttggctagt agtggggata taattccccc ctgtggagtt cctttctctg
     3661 gatatgttat tgtgccgtca ggcattttaa ttggagcttt taatatcctt tttaaaatga
     3721 atatcaagtg cttgtcccgt attcccatag cccatatctg ttttatcagt ttggaatggt
     3781 tcacgttgtc aaagaaaccc ttaatatcaa attcaatcac ataatgtagc tggctgattt
     3841 gtaggcggtt ataggttgct tttattgcat tttcaaccga cctattaggt ctgaaaccgt
     3901 agctgttttc actaaattta gcttcgcaga ttggttctaa tacttgtttg atacattgtt
     3961 gtataagcct gtcccacata caaggaatgc ctagaggtct ggttttccca tttggttttg
     4021 gtatttcttt tcgccttact ggcttaggtc gatacccgtg tggagtgcct gcgacaatat
     4081 atcttacctt tttgacaact gtttctgctg gcaatttgcc aatatcttta attattgtac
     4141 cgtctgttcc tgctgtctta ctgcctgcat ttgctttgat atttcgatat gccagtaata
     4201 tattttctct cgataggata atatccataa gatgagtgaa aatatctcca ttcttacttt
     4261 tggcatataa atcatcaaag gtgttttgca tttcgtaata ttcagcgtgt cttaaatctt
     4321 ctacacacaa tgtttcattt ttatttttag gcataaggct tcactccttt gcttgaaatt
     4381 gagtgagctt ttttatctta ctcgtaatcc ttattaaaac aacataatac ttttctaata
     4441 tatacacgac ttgagggtat tcctccattc tcattacaag aatttcttag gttcgccctc
     4501 tgcttttcag cattggttca actgcttatt gttcttcgtc agcttattct cttgatgaga
     4561 acccaatacc tttcctcgtt ccgataatct tatctataca tatatatcct taggtcacta
     4621 gctataagcc tgctggcttg ataccgcctg taacggtata tggcatttca taacctatat
     4681 tcttactttg ccacaccagc tacgatttct cgtacctttg catttctaca aagtacaaat
     4741 ttagacccgt acattcgctg tttcgtcagt cccttgtgga acattctaac catagatatt
     4801 ttatagaccc ccgacctgtt ggatacgcta cccacctctg gatagttttc gatagaagat
     4861 atatgttcat caactattac ggtatctttc agccgtcttt accgagcttc aaacattctg
     4921 agtttcctca ttcaatgctt gtcggaggct cagggcaggc gtttcagagc gttacttcat
     4981 cattccacct gtcagattat cagttctcct aataatcaaa ctttttcgtt cttttattag
     5041 tgccttagct tttcactaag gaacgagtcg cacataaatt ttgtccaaaa ttcatttaat
     5101 gttcctctct ttctttgatt tcttccatac atctgtcagc ttctttgccg acagttaaaa
     5161 tgcacatcaa gactacgccg atacccattc ccagagatac cagcaggaag tctttcaata
     5221 attcccacat ttttcatcac tcctttactt tggcaaccat ttcttcaacc gtggctgtct
     5281 gttgcttgat tatctggtgg tgtcgctcgg tcagttttgc ctgcttctca atcgtttcca
     5341 gatactccgt ctgattgtcc ttgtctatct gtttcaacat cttcaaggtc ggtgcaacct
     5401 gcctttgtag ccagttgagt gtacgttcta acgtgtacgg ttttggcttt gttgtcagct
     5461 ttacgggtgg tcgcccctcg ccaatgaacc aagcccagcg tacatttgtt ttccagtcgc
     5521 tttttcgctt gtctggttct ttatcagcaa agcggatata ctggttgata atagaaaatg
     5581 ctgtctgttc tgcgtcataa tgtgtcagca gttccacaac agcataatag gcacgttcat
     5641 ttttcaaacg tatctcaaat ctatttttta tggggacttc ttcaatcggt atgccaagtt
     5701 ttgcgtactg ttcgtaattc ttttcataac agcagaagta tacttcactt gaaaatgaac
     5761 cgatatacaa cgtgtgtccc ataccgtatt tatccgtttc gttatgcttt accagttccc
     5821 cagaaccata gcttttgaaa gaacggaatt tagaaataca ttcctcattc tcgcattttt
     5881 gtatcagctc tggaatatca agtaaacccg ttcggtcatt gattgccaaa tcaagacgtt
     5941 tcatcacacc gccctcaacc aatgcgtccg tgaagaagtc ataccaattt cgctcttgtg
     6001 ccagcagata actttcaaac tgacgacagc ctttgccttt gagttctagc aggacacctt
     6061 tttcctcgtc ctgcgataca tacacaaaca catctccgat atgataatgc tcggtgtatt
     6121 tataatgtcc gtaatcttcg tgaagcatat agtcgatatt gagctttaat atattcttga
     6181 tgatatgctt tatatccatt gtgggaaaac ggatacgcac ataatcaaac agcaggaaca
     6241 tgggattgtc gggattgaat ttttccaccg cttctaaaag cgtatgtttc atgtcctcag
     6301 tcagcgttac ctttcctgct tcgatacggc tcaaatgttc acggctgata tttgccatga
     6361 ttgcaagcct tgtctgcgat acgctgtatg cacagcgttt cgctttcaag gcggttaaaa
     6421 aatcagtttc attcagttgt cataccccca atcgtgataa ttttgtgata ttgtgataat
     6481 ttcaaggttt tatcacaaaa ggcgagatgt acgaaaaacc ctcattccat gcggtcttgc
     6541 aaaggttttt gtggaagttt ccgccgtaat tgtgcccctc tgttagataa tgaggggctt
     6601 gtttctgctg gtgtggcgtt agccacacca gcaacggcta gtccgtgccg tcgcctttcg
     6661 cttcgcacgt cgccgtcccg tcctgccttg catatgcaag agaacctatg gtctgcaaaa
     6721 aatcatatcc tttcgggact aaaggcgtgt aaaattcact tatgatgctt gttcccacat
     6781 cacaatagcc acgccctttg atacgcttct ggaaaaactg ttttttcaca tcagaaccaa
     6841 acagcatacc gtaacctaat tcgctgatac gtcccaaccc tacacggaaa ttgaagttat
     6901 ctctgatacc gtccgagaaa tattttgcgt ctggtcgctg gcaggcaacg ataaggaaat
     6961 accctgcttg tctccccagc atgacgattt tctttaactg gctaagtaaa ctcacgcttt
     7021 cctttgtccc cagcatttca aaaaacgcca catattcatc aaagattaaa aagcagggcg
     7081 gtaagctaag ataggcgtag ttttctcctg ttttatagtt cgggtgttgc ttcatttctt
     7141 cgcttcgttg taccatgccc tcataaaagg cattgacgca atcaatcatt tcttctttag
     7201 tgtgatacac gtttcccatg actgttccca aatctgcaag gtcagcgttc tttgggtcta
     7261 agatgtaaag gacagcgttg gtatgcagta gggcttcaat gagcgtcaga agaaaatagg
     7321 ttttaccgcc accagtccca ccagcaatca gagcgtgagg gagtgcgtca tattcccaga
     7381 caagattttt catcagtcta agacagccgt tttctgcccg tacttcatca atagtaatgc
     7441 ggtttgctat catgtcataa agcaggatat atttaatata gccgtcatgt aaggtcttgt
     7501 cggtcagctc gcaatacaag ccactttcca atttatcctc taaccgtaaa agttggtctt
     7561 gatattttcc taatgtgatt tcacagcgga tatgaagcag tcccttttcc atttgataat
     7621 aaatctttgg aaaccagacg attttttccc ttgatctgct ttgcaggtca gtaaaaaaac
     7681 cgctgtcttg tacggtatcg gcttcatacc acttattttc cagtatcatt cgtgccagct
     7741 tttgacggtg cagtagcttt ttaaaattgt cataacaaaa gcggtaatac agaaaagcga
     7801 ccaatgcaca aacaccagtc gctatcagta aggttatgaa gttgtataag gaaagcgtaa
     7861 agctgttgtc taataagctg aaatgttccc agtcggtacg catgagctgt ttcatattca
     7921 gtagcagaag aaccaccacg aatacaatta gaagcgttcc caatgaaaag cgatagacga
     7981 ggttcttatc gctggctctg atacggtgtc ctttattcca aattattcgc ataaatcaat
     8041 cactccaatc ttaaatttaa gtatgaaaaa agcagtcaat cttaaaagac taaccgcttt
     8101 gtgtgtatga atatgaagtt gttacattgt agggtatgtt cattatatat gctttgttgt
     8161 tttaactctt gattgtgcaa tttcttcaaa tagctgtttt tcgtttaggt ctttaaaaac
     8221 tcttttggga attaacgtat ataatcgtgg tgcttgaatt aagtaataaa aatcatggct
     8281 ttcccatagt gcagagtaaa tgtcccactt cacttctgag tcaatgcttt gtgttttaaa
     8341 tttaatgttt tccttagaaa ataccagcgt atattcctca tgatattttg cagtttgttt
     8401 gaatttcagt ataggcatta ggatatataa atagcttccc aatgcagtta caactctttg
     8461 ctacaatttc aaatttgaaa atcacttttt cttgaaaagt ttcagtttta tatttctcct
     8521 ttcagcaatc ttctgaaaca cctccaccac atacaagcat tgtgccttaa atggtagtaa
     8581 ggtcaattcg tcattggatt gtatttgttt cattgcttct tgtaattctg aaagttctaa
     8641 taaattgact gccacacaaa agaaagtctt tctacgcccg tcattatagt tagaaagtaa
     8701 gtaagaaaga atttgtgttt tttcctgctg ttcaagatta tattgctcaa tgcctatgtt
     8761 ttttgctctt tctaaatctg cttttcgctg tttatgcgtg atgaaagaat cataatcatc
     8821 aatgtgttga tatttttcgc atggatattg tttgcattca tagcaatatt caatctgtcc
     8881 atgttcaaga ctacattttg caattctgca tgattgatta ccattgccac aaccgccaca
     8941 gtaatttccc aaaagcatag ggcatagtcc gcaattcaat ccgcaaagag aaaataattg
     9001 gttttttcgt tcaaatcctt tcatagtacc agtctcctaa cttcaaattt atctttgtat
     9061 ttattgactt ttacaaactg ggatttatct ggcagacttg tttatccact catcaagaaa
     9121 tttcatttgt tcttccgtgt gaaaccaatg ctctccgttt ctcataacag taagtgttgc
     9181 attagtttgt tttgtaaatt cagatatagt tgcataagaa gtcaagttat ctttctcacc
     9241 aaataaaata tttgttggaa ttttccatgt agttggattt tcttttacat aacagagata
     9301 ttcccatgag agtgtttctc caaaagttgt tttaatttct tttttatctc gaagttcatc
     9361 ttctgtaaca tttgcccaat acatcatatc tgcaatcagt ttttccatat tcacaatagg
     9421 tgaaataaaa tatgcttttt ctatttgctt atctgataag gcgttcatgg cgaaataggc
     9481 acctatgcta tttgcaacta tttgaacaga tttgtaatgt ttgcaaatca aatcaaaaag
     9541 tgatggaaat tcttcttttg cttcccatgg atattgtgca gtatagttga gtccaaccac
     9601 atcacaatca ctaaaaagag gtttgtaatg tgaagactcc tctgcatttc cacctttacc
     9661 atgtatataa ataactactt tatccataat agttgtcctc ctcaacttcc gatttgtata
     9721 ctaaattgaa gtataaaatc atcatttcct gttgggcttt ctttttattc ccaataattt
     9781 aacaaaatca ttaaataaga ttgtatctgt tggctcaaac atcaaccatt ttccgtcatg
     9841 ataggttttt gtttcatcat aaattttttg cacttctttt gaataactat ttctatctgt
     9901 atcaaatttt aatcgttcat ctttccctaa gataatcata aatcctacac agttttccct
     9961 tgcgtacaat gcacaaagcg tttttccgcc acgacgatat ttatactcat aagtccacgc
    10021 tttaccacct ttgttccata aacattccat gtcatacttt tcatcaatta aggcacacag
    10081 tttattccat atagcatata atgattgccc gactaaagca gtcatttctt ctgcattagg
    10141 tattttatcc agcatactca tttctccttt ataacttctt atttatcttt gtatttattg
    10201 acttctacaa acaagaattt atctcataca ggcatttata aatttcatag gcacgtccat
    10261 gcgttctgca acttgttctg gtgtcattcc gctatttaag aaacgcttgc atactatttt
    10321 catgttttct ccaacttcga taatatgttt atctgggtca taaaagcgga ctacacgttg
    10381 tccccatgaa tgttctataa tagggtggac atattcaata tcatattctt tcagcctatc
    10441 agcaaattta tcaaaatcat cttcttcaaa atagacttca aaatttttac cgccaaaaga
    10501 aatatcactt gtaccgataa actctttgta tgtttcactt gtctgtaagg ctaagccacc
    10561 tgttaaagtt ttatttgctc caaaatccat aattacacga agtccaaaaa cttttttata
    10621 aaactcaact gatttatcta tatcagtcac taccaacata ggatttttaa atttcatttt
    10681 cgctacctcc gcaagttcaa attatctgtt tccataccca tattataaca gtcacttata
    10741 tttgctacaa tgaaaatcta gtttgccagt ttattttttt gttgtccttg tggtgcaagg
    10801 ttctgtggat tgttgttctg tggatttcct gctggctggt tgcctttgtt cttcaagata
    10861 atatcgtcag ccttgatgta ccagtccaca tcagcccctc taaagttggc atttgccacc
    10921 gtatcagcta cgggattgat taactccact tccgcattat aaggaaagtc ctttacggga
    10981 acatcagcgg ggattgacac ttgtatcatg cgttcctgca cactacattt caaatcataa
    11041 gtacgacgct taatttcatc acttgtcgtt ccgtcctcat tttctacacg cacctcatgt
    11101 cgaagtgcag agaatttcaa tactccaaaa gttttttcgt tatctaatac aattccattt
    11161 gctaatctca taatcaaata cccccttatt tgctttctgc tggtaacata tcatcagcca
    11221 ttaaaatgta gtttgtaaat ccacgtcctt tgacgttgta accctctgcg gtaatgcgtg
    11281 ggttaatcag ttttactttc tgctctggct taaaatgctt ctcgccagct tttgcaggca
    11341 atacaacgat aatgtcgtcg gctctctgaa tatccgaata caagttgtaa cttcttgata
    11401 cgggagtgta acgcccattg atatgttgct ggtctacttt gttttcccct gcaaattcca
    11461 agtttccaaa agtctgtgcc acattcggca cgatatattt taattccata ttgttttacc
    11521 tcgtttcttt ctattagttt gattgttttg tattctggca gttaatgaga taccagcaag
    11581 cccagacagt aaagggtaaa ctgtatgctg acgcactctt gacgatctgg gttcttgcag
    11641 gtaatcggca gacaagccag aatagaagta gtctgcctat ttaagttacg gcggagagcg
    11701 tgatttttct tttctcatgc agttaccgcc ttatgatttc ttcatcttac ggcgtttgaa
    11761 gaagtatgta ccagccagac cgccagcaga aacaaacatc ataatcgcaa aggcaagaat
    11821 atttgtattg tcgcccgttt ttggactgtc tgttttcgtt ggtgtatctg gtgtagttgg
    11881 cttctctggt tcttctggcg taggtgtttc tggtacttcc ttaatagtaa ccgtctgccc
    11941 gtcgtcctca atgtccttat gctccgtaac ttttatcggt ttgtctggat tgcttaaatc
    12001 gtataattcc tcaaaagtta caaactgttt accgccaaga gaagaagcgt caaaagtaaa
    12061 tgcaatcttt acttccatag tttcactgtc agacgtaaat gtgtagtcat tttcaacttt
    12121 tttatcattg atgataagct ctgcattttc ttcttttaac atctgccagc ccacaagctg
    12181 atactttgta ccgacttcta agccctctaa cttgaccgta tcaacaatcg ttacgtcctt
    12241 gccagcttca atctctttct tgccgtcctt gtccgtagct gtggtatgga ttttgatgat
    12301 acgttctgtg ataagtaccg tttgtccgtc gtcctcaata tctttatgtt ccgcaacttt
    12361 cacgggttct tctggattgc ttaaatcata caattcttca aaagttacaa ggttcttacc
    12421 gccaagagca gacgcattga atgtataagc gatttccact ttcatagctt catcatcagc
    12481 gacaaaggta taatcacttt ccactcgttt atcacctaca agaagctcgg cattttcttt
    12541 tttcaacatc tgccagcctt ttaactgata ctttgtacct tttacaagac cgtctaattt
    12601 gaccgtatca atgatagtaa cgtcattccc tgcaaggata gtcttttcgc cgtccttgct
    12661 ggtagcagta gtatggatag tgatttcttt ttcgtattca tcagtcagcg tacctaaatc
    12721 aaccacaacc ttatttctgg aaatgacaat ctcaaacggt ggaataagtt tgaagccttt
    12781 gttgctttca caacgtaatt cttcaatgat gtaggtatca taaatcaaag cacctttgct
    12841 gtcgtctggt tcagaagtac caaaccacac accgtcctcg cttgtttttc ctgcattggt
    12901 attgtgcttg tgggaagccc aatcagaagc agtagagaat tgtccgttat catcagttac
    12961 aacaacatga ctttcgcccg tcgtcttgct tgtgatccta aacggaacat ctgcaagacg
    13021 cttgtgcgaa cctgcaccaa tttttacgcc ctcaatatcg ccacgtttaa tctggttata
    13081 gatagagtgg gcttcgtcag tcaaatcaac gatttttcca ttctctgtga tttcaaaatc
    13141 aatcggcttt gcaccgtcag tcaaatatcc ctctggcggt ttttgttcag acaatctgta
    13201 ttttccgtaa ggtaataggt cagcagaagt agaagcgata ccctcaatgt cggtatggat
    13261 tgtctttaac acttcatttt tcttgtataa cttgctctca actaagacgg cattctcatt
    13321 taaggaaatg atttcaaagg cggtattttt caaagtcgca ccgccttgag ctttcgtgtc
    13381 tttggtttct aaatctcgtt tctggatttt tacaccgcca cgaatgactt tatcagaaac
    13441 atggtattga ttgcttccag acaatacggc aaggtcgccg tcctctgtaa tctgtgtcag
    13501 atacatttct tttatctgtt cttcgctacc gtctgcctgc atatatgcac cctctaataa
    13561 gtaaccagac ggactttttg tttcttcgac ggttagtgtt cctaaaggaa gcacgttttt
    13621 accgtcctgc atatagaagc tgtctccaga tactttataa gcgttagcta aacgggtaat
    13681 gtaatggata gctccgtcgc tgtctttttc agcgatagtc tttgttaccc atgttcttgt
    13741 aggctgtgct ggaagattgt tcttgttgta atatccagcg tagaagttcc atgtaaactc
    13801 tgctccctct aaagaagcgt ttccctgcga attggatttc tgtgtttcca tgtcaatctt
    13861 gaatagctca atcaaggtat ctgttacttt tggtgtatca gatactttta aagtcgctgt
    13921 ttttccagct tccacagata aagagtaaac tgttttatca attttaaatc ctgctggtgc
    13981 agaaagttcc ttgatatata ctgtagtggc tcttacttca acggcttctg tatttccgct
    14041 ggtatcagtc gtaagggtgg caagctgttt cgtgcagtct ttatcagaat acacaccgta
    14101 tgttgcacca gcgattgaat aaatcccgtt gccgtctgta atattggcat tggtggaagt
    14161 cttttgaagt ttggcatttc cgacagctaa cttcgcccag aattgcccta actcttgacc
    14221 ctcgccagaa tagatatatc cgccacagtc ataacgtcct ttgttttctt tcacaaaggc
    14281 ttttgctcct gcgaatactt catcttgtac ggcttttggg atttcatcat aggaagctcg
    14341 cacattatcg cattgccagt caagctgaac acttaatctc tgccagacaa caagctgttt
    14401 taataggtag gcgtgtttac tgcttattcc gctgtggctg tctgtgtact gtttcacata
    14461 ctcaatagat aaggcaacgt cgcttatccg gtcggcactc atgcgtgagc ttgcgtctgt
    14521 tctggtctta tagccgtttt taaacgctgt gttgatgtca atacaataag cgtccttgcc
    14581 ctcaacggtt aaatgtccct cattaaaggt agaactgata gaaccgtcat tcattacttg
    14641 ttctacgata ccgacacgct ctttactttc cgtccaatac tgtgtattag acgcatgaac
    14701 cgttgaactc ggtaaagcgg taacgacagt tgcaaaggca agaaagcctg tacacaatcg
    14761 ttttaatatc tttttcataa ttctaaatgc tcctttcatt ttggtagtaa aatagccgtc
    14821 cactaggaac ggctggaaat agaaaaggaa cgctgatatt gtgcgttccg tagtctatga
    14881 agtattcaat ttttcttgtt tcaatactga tgtgctgtac cgtatctttg catatctggg
    14941 aaataggacg tatcaaggct cattcaatcg tagtaaatta gtagtatttt gatgtgttta
    15001 gctccttgat aatgccgata gatacagcgt tttagcggat aatcaaattt ttagtgtgtt
    15061 tttgatataa aaataataat acaatacatt tgtatagtat tattctaaaa ttctatatct
    15121 aaataaaatc acctctaaaa tatttaattt ttatctttat ttgtcataat taaatgaaat
    15181 atatatttta aagaataata aaagatagct tattgtacaa aatttaaatt ataaaaactt
    15241 agtttaatca aaggcaccac tttttttcat tttagattat atataaacac aatataaat
//
LOCUS       DAEQCW010000088        15110 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.089, whole genome shotgun sequence.
ACCESSION   DAEQCW010000088 DAEQCW010000000
VERSION     DAEQCW010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15110)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15110)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15110
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.089"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(159..323)
                     /locus_tag="KRO40_002733"
     CDS             complement(159..323)
                     /locus_tag="KRO40_002733"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093546.1"
                     /translation="MKSLLNSTLISSGLIATMFISSSIKSIVPIKSATPRANLNLNNS
                     SLVKYSYFQF"
     gene            533..1600
                     /locus_tag="KRO40_002734"
     CDS             533..1600
                     /locus_tag="KRO40_002734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2093547.1"
                     /translation="MKFKKLVSLGILSTLLLSVITGCSNVSSGSNLKSNNKTKGELTV
                     YTAIEEDSIDTYLATFKEKYPDIKLNVLRLSVGGITARLLAEKDNPKADVLWGVAATS
                     LIILDDKEMLEPYAPKGFDKVNSAFKDDKKVPSWVGIDAWMTGITVNTKELKAKNISA
                     PSSYEDLIKPEYKDLISMPSPASSGTGYLTVSELIQIMGEEKAWQYMDKLHKNIGVYT
                     QSGSAPAILAASGEYPIGISFGNRGIKLKGEGYPVEVVFPKEGSGWEIESNALVKKDN
                     IKEASKVFLDWAISKDAMNEYSKNFAVTTIDTGNPVPEGFPKNPLEQMIDNDLKSAAR
                     NREAILNKWIEKYDGKTEKES"
     gene            1792..2322
                     /gene="rnmV"
                     /locus_tag="KRO40_002735"
     CDS             1792..2322
                     /gene="rnmV"
                     /locus_tag="KRO40_002735"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HBH2093548.1"
                     /translation="MIKEIIVVEGRDDVTAVKRAIDAELITTGGFGFPKGVMERIKAA
                     NERRGVIIFTDPDFAGEKIRKKIASEVPGCKHAFLPREEAKKDGDIGIENATPQSIIA
                     ALNKVRTENTEKRDEFKQVDLIRNGLIGNEEASLRRDALGKILGIGYGNAKQFLNRLN
                     NYGVEREEFIDALKQI"
     gene            2493..3362
                     /gene="rsmA"
                     /locus_tag="KRO40_002736"
     CDS             2493..3362
                     /gene="rsmA"
                     /locus_tag="KRO40_002736"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HBH2093549.1"
                     /translation="MDRLSSHNATKEVVQKYNFKFSKSLGQNFLIDSNIIDKILSGAR
                     ITRGDNIIEVGPGIGTLTREMGKIAEKVVAIEIDRNLIPILKDTLSDLDNTEVVNQDI
                     LKVDIQELVKDKLNGGPVKLVANLPYYITTPIVMKFLEEDIPVTDIVVMVQKEVADRM
                     NAIPGTKDYGALSIAVQYYCDTEIVAKAPRHMFIPQPNVDSTVIGLHVRDKRKYDVHN
                     EDIFFKTVKASFGQRRKTLLNSLGGLGFLNKDEIREVLKEANIDEKRRGETLSIEEFS
                     VLSNIINTKVSSK"
     gene            3428..4690
                     /locus_tag="KRO40_002737"
     CDS             3428..4690
                     /locus_tag="KRO40_002737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093550.1"
                     /translation="MGSKRKFKRDYIILEAKDINFRYKERVLPKAFAKVEVNDEKAII
                     ALYVENLKYVKDGYKAVAIKDDHGLIDLGNIILNEQGRGEFVLDLEDYDDEIKGIALL
                     YERNIPLIGFKGNKLENYEDILFQEVEEEEYEEYEELEEEDEEIEENEESDRDEDSEE
                     EYIIEEYDEDEYEDYWEDDEDIEEGELKARTEVEDSDDEEIEEFNNYKEIENYNRVKV
                     QEEYIDIEYDEEEEEEEVFEVNREEDRFVSSKPTKSKKVQKDQNNIEKIKRANGVSQG
                     ESGNKQTSTLLMPRQIKKGLKLFKEVKPFVTDYIDKTRWWKIEINPTTLCGYTMPYLG
                     YLNVLNYTMYSDAVLHSYKYRHYLFGVQYDEYNKRKHYIYAIPGNRNEQPDNGSTGFL
                     RYQACDNRTNSLGYWLCFIDSRQRNIVR"
     gene            4841..5956
                     /locus_tag="KRO40_002738"
     CDS             4841..5956
                     /locus_tag="KRO40_002738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2093551.1"
                     /translation="MINEQRILNEFLELVQIDSLSLKEGNVAKVLVKKLEEIGCSVVI
                     DNAGEKANGETGNIIATLKGNKEGKKILFSSHMDTVTPGIGVKPIVDEANGIIKSDGT
                     TILGSDDKAGIAAILEGLRYINENNIEHTDIQVVFSICEECGLVGAKNLDYGKIDSEY
                     AFILDSGGSPGEIIVKAPAQDVINVKILGKTAHAGLEPEAGISAIMVAARAIENMNLL
                     RIDEETTANIGIINGGTATNIVTGEVNIVAEARSLKENKLDVQTKHMVETFEKAAKDF
                     GAQIEIDVNRAYTPIDVSEDSEIIKLAKKAFSNLGIEGHTESTGGGSDTNILSKNGIE
                     AITLGIGMKNAHTLSEHIAIKDLYDSAKMVVEIIKEA"
     gene            6142..7038
                     /locus_tag="KRO40_002739"
     CDS             6142..7038
                     /locus_tag="KRO40_002739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBH2093552.1"
                     /translation="METRYEEANKITIQSILWNIVLTIIKVIAGVIGNSSAMIADGLH
                     SASDIISSIGVLIGNYVSSRPGDREHNYGHEKAETLVSFVLSILLIFVSITIGIEAIK
                     SLFNLDALSVPSILPLVVSVISILIKEYQYRITIKVAKKINSPALKADAWHHRSDALS
                     SVAAFIGIGGSILGFKPLDPIASVVVAIFVAKVGISILISSVNELMDVSVDEEEIKEL
                     KFIVADTEGVKNLGDIKTRKHGAMAYVDLTICVDENLTVKQGHDIATKLEKHIIKHME
                     FVKGITVHVEPCTNCQGNKCNN"
     gene            7108..7905
                     /locus_tag="KRO40_002740"
     CDS             7108..7905
                     /locus_tag="KRO40_002740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093553.1"
                     /translation="MSKKRKLKKKAAILIGVVVFFIIYFISFRIGINMEKDKSEVPKK
                     VEKEEEDNRSLRTQIKEKKKVYISDKNIENIKIEEDMWDEIKLFFSDFKKVRNTTSSY
                     EAVYEGYSDDGVKFSTDLNFFRVYTVNKEEYYKVPVSSKDAFKKLLDESIYTSFDLLS
                     HYKDWKEVTITHGKEIKKVHRWKFDDLAHKMISKRVVGKVQPEKSKERSDYNFTINIK
                     GDNFDVKVDTMGKDYVKVTSKKNVSYYEVHTSLFDYLKNEIFEIGKK"
     gene            complement(7960..9312)
                     /locus_tag="KRO40_002741"
     CDS             complement(7960..9312)
                     /locus_tag="KRO40_002741"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HBH2093554.1"
                     /translation="MNIHFIGIGGISMSALAEICINKGYQVSGSDSNESYLLDKLRDQ
                     GATIYIGQKKDNISDDVNMVVYTAAVHPDNEELVAAKEKNKLVMNRATFLGQIMREYK
                     NSIAVSGTHGKTSTTSMLSTIFEYADLDPTILVGGNLSMIGGNVKIGNSNHFITEACE
                     YVDSFLNFNPKISIVLNVEEDHLDYFSGIDEIKASFNKFGKLLPPEGYFIINGDDENI
                     DDILYDVKATIIKYGRDSDNDAVIKDIHFDNSGHGIFRIEYEGRDLGEFELSVYGLHN
                     IYNASSAIMAALVSGIDLETIRKNIKIYKGVGRRFETKGYYKNALVVDDYAHHPTELK
                     ATLAAAKKLKKSTLWCIFQPHTYTRTKSLLGEFSEAFYAADKVIITDIYAAREKDPGD
                     IHSKDLVEKLYQNNVDAIYIKEFEDIVKYLRENVKDNDLVITAGAGPIYKVADLLVEK
                     "
     gene            9531..10409
                     /gene="purR"
                     /locus_tag="KRO40_002742"
     CDS             9531..10409
                     /gene="purR"
                     /locus_tag="KRO40_002742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HBH2093555.1"
                     /translation="MKFKRTERIGAIVKILSDNPNKIYTLSYFTNQFNAAKSTISEDL
                     LVVKNVFEKLHLGKVITISGAAGGVKYIPKTSIAENAEFLMELCERICDKSRILSGGF
                     LYLIDLIYDPTIAAKIGKIFASNIEYVDADYVVTMETKGIPMALMTAKAMNLPLVIIR
                     KDIKVSEGPTLSMTYVSGNSSKVESMSLPRKALKPDSKVIIIDDFMRGGGTIKGMVDL
                     MNEFGAEVIGTGVFISTTNPSEKMVKDYISLIQLDVNGDKIVVEPNLKTFKDEYRNED
                     LDEEEDSEFEFEIDED"
     gene            10565..10843
                     /gene="spoVG"
                     /locus_tag="KRO40_002743"
     CDS             10565..10843
                     /gene="spoVG"
                     /locus_tag="KRO40_002743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation regulator SpoVG"
                     /protein_id="HBH2093556.1"
                     /translation="MKITDVRVRKLTEEGKMKCIVSITFDNLFVVHDIKVIEGHNGLF
                     IAMPSRKVGEGNFRDIAHPINAEMRQVLEDAVLQAYHEALVQWEVAAE"
     gene            11056..12435
                     /gene="glmU"
                     /locus_tag="KRO40_002744"
     CDS             11056..12435
                     /gene="glmU"
                     /locus_tag="KRO40_002744"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HBH2093557.1"
                     /translation="MNFKAIILAAGKGTRMKSKYPKVIHKVCGKEMVNHIIDVSKKSG
                     VKDTVVILGHEADVVKEKLAEEIIIAMQTEQLGTGHAVKMAKEYINDEDTIVVLCGDT
                     PLIKEETLKRLFEYHIENKYHATVLTTRVGNPTGYGRIIRDKKGDLLKIVEQKDANSE
                     EKMISEINSGIYCFNGKSLREALDLLNNNNSQGEYYLTDTAKIMRDKGLKVGAFAGST
                     IEELMGVNSRVELSKAEEIMRRRINESHMVNGVTIIDTNSTYIESDVMIGNDTIIYPG
                     VMLQGKTRIGSDCIIGMNSSITNSEIGDGTEIKNSTIIDSKVGENSTVGPYAYLRPKS
                     DLGNNVKIGDFVEVKNAIIEDGSKASHLSYIGDAHVGKNVNIGCGVVFVNYDGKNKFK
                     SIVKDNAFIGSNSNLVAPVVVEEKGYIATGSTITHDVPDGALAIARERQVIKEGWVEK
                     KNQKDDQSK"
     gene            12530..13480
                     /locus_tag="KRO40_002745"
     CDS             12530..13480
                     /locus_tag="KRO40_002745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="HBH2093558.1"
                     /translation="MNTSGSEIKIIAGNSSKELAQKIADYIGVSVLDCEVGTFSDGEI
                     CVNMNETVRGCDVFVVQSTNSPVNDNLMELLILIDALKRASAGRITAVIPYYGYARQD
                     RKAKARDPITAKLVANLITAAGADRVLTMDLHAAQIQGYFDIPLDHLLGGTILANYFN
                     EKKIEDLVVVSPDLGSVTRSRKFANTLNGEVPIAIIDKRRPKANVCEVMNLIGDVKGK
                     NVILLDDMIDTAGTIVNAANALKEFGAKDVYACCTHGVLSGPAIERIANSEISELIVL
                     DTIQLPEEKRIDKIKIKTVAPLFGDAIRMIFSNESVSKLF"
     regulatory      14318..14403
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            14565..15086
                     /locus_tag="KRO40_002746"
     CDS             14565..15086
                     /locus_tag="KRO40_002746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH2093559.1"
                     /translation="MKLKKNKKGFTLVELLVVIAIIGILAVVAVPALFSNINKAKVAS
                     VESDYSSVKSAALSYYSDTNKIPVTPDGQTGLSVLETYMESLPDKADIGGKYKLIKVG
                     NKLVLQIGTNTEGVTLTEAQSAKLLSDIGENKIYTSTTTNSLGNPLTSNTKIDNNVLY
                     IVLIDNTVMDTTK"
BASE COUNT         6099 a         1569 c         2753 g         4689 t
ORIGIN      
        1 tgttatatat aaagtaaata agatattaaa taattataaa ctaaagtaaa taaaatattg
       61 agcgattatt aaaaagatat atatataatt taatttgagc agtttgttat atattataaa
      121 aaaagagaaa aataaaaggt aaattgtttc tggataactt aaaattggaa gtaagaatat
      181 ttaactagag aagaattatt taagtttagg ttagctctag gagtagctga ttttatagga
      241 acaatagatt ttatggatga tgatataaac atggtagcaa ttagaccaga agatataagg
      301 gtagaattta atagagattt caaagaaatt atagacctca aactcagacc gtatcgatat
      361 aaaaactaaa gttagatgat atagtgttgt agataggacc atcagctgtt atggcagtat
      421 tagtgctttt aacaaatata atagtaaaac ttttgtatga attgataata aaaaaattaa
      481 aaaccaagac ataaaaatgg caacaaaaag aagttgaata agggaggtaa aaatgaaatt
      541 taagaagtta gtctctttgg gaatattatc aacactttta ttgagtgtaa taactggatg
      601 tagtaatgtt tcatcaggtt caaacttaaa gtctaataat aagacaaaag gagagttaac
      661 agtttataca gcaattgagg aagatagtat agatacatac ttagctacat ttaaagagaa
      721 atatccagat attaaattga atgtacttag attatcagta ggaggtataa cagcaagatt
      781 attagcagaa aaagataatc ctaaagcaga tgtgttatgg ggtgttgcag ctacaagttt
      841 gataatttta gatgacaaag aaatgctaga gccatacgct ccgaaaggct ttgataaggt
      901 aaattctgca tttaaagatg ataagaaagt tccttcttgg gttggaatag atgcttggat
      961 gactggtata acagtaaata ctaaagaatt aaaagctaaa aatatatcag ctcctagttc
     1021 ttatgaagat ttaataaagc cagaatataa agatcttata tctatgccta gtccagcttc
     1081 ttcaggaaca ggatatttaa cagtatcaga actcatacaa attatgggtg aagaaaaagc
     1141 atggcagtat atggataaat tgcataaaaa tattggtgta tacactcagt ctggttcagc
     1201 tccagctata ttagcagctt caggagaata tcccattggt atatcttttg gaaatagagg
     1261 tataaagtta aaaggtgaag gttatccagt agaagtagta tttccaaaag aaggttctgg
     1321 atgggagata gaatcaaatg cacttgtgaa aaaagataat ataaaagaag catcaaaagt
     1381 atttttagat tgggctataa gtaaagatgc aatgaatgag tattctaaga attttgcagt
     1441 tactacaatt gacacgggaa atccggtgcc agaaggattt ccaaagaatc cattagaaca
     1501 gatgatagat aatgatttaa aatcagcagc aagaaataga gaggctatac taaataaatg
     1561 gatagaaaaa tatgatggaa agacagaaaa agagagctaa gccttgcaat aaaatttagt
     1621 acaaaaagcg cctagaatat aagttttata tctaggctct tttgatatat ttatttaaaa
     1681 tgcatatttc tatataaaaa taaatagttt agtaccttga ttaaattaaa taaaaacctt
     1741 aaaataaaga gatgtaaaga aaaactaaaa acgaataaaa ggtgaattta tatgataaaa
     1801 gaaataatag tagtagaggg tagagatgac gttacagcag ttaagagagc aatagatgca
     1861 gaacttataa ctacaggtgg atttggattt ccaaaaggtg taatggagcg tataaaagct
     1921 gctaatgaaa gacgtggtgt tataatattt acagacccag attttgcagg tgaaaaaata
     1981 agaaaaaaaa tagcatcaga agttccagga tgtaaacatg catttctacc gagagaggaa
     2041 gctaaaaagg atggagatat aggtattgag aatgctactc ctcaaagtat aatagcagct
     2101 ctgaataaag ttagaactga aaatacagaa aaaagagatg aatttaagca agttgactta
     2161 attagaaatg gtcttatagg taatgaagaa gcatcactta gaagagatgc acttggaaaa
     2221 atacttggaa ttggatatgg aaatgcaaaa caatttttaa atagattgaa taattatgga
     2281 gttgaaagag aagaatttat agatgcatta aaacaaatct aaacgtaatg tttaatgtat
     2341 gaaaaatatg tatataaaat aaattgtgga attacggtta atttaagatg aattatttat
     2401 aatatacacc ttattttaaa tcaatgtaaa tacatataaa taagtataat taataaaatt
     2461 aaatatcaaa ataagttaaa aaggagtaaa taatggatag actatcttca cataatgcaa
     2521 caaaggaagt agtacaaaaa tataatttta aattttcaaa gtctttaggt caaaatttct
     2581 tgatagatag taatataatt gataaaatct tatctggagc tagaatcaca agaggagata
     2641 atatcataga agtaggacct ggtataggaa ctcttactcg tgagatgggt aaaatagcag
     2701 aaaaagtagt ggctatagaa atcgatagaa atttaattcc tatattgaaa gataccttgt
     2761 cagatttaga taatacagag gttgtaaatc aagatatact aaaagtagac atacaggaat
     2821 tagtaaaaga taaattaaat ggtgggccag ttaagcttgt agcaaatctt ccatattata
     2881 taactactcc aatagttatg aaatttttag aggaagacat acctgtaaca gacatagtag
     2941 tcatggttca aaaagaagtt gcagatagaa tgaatgctat tccgggtact aaagattatg
     3001 gggcattatc tatagctgtt caatactatt gtgatacaga gattgtggca aaagctccaa
     3061 gacatatgtt tataccacaa ccaaatgtag attccacagt tataggtcta catgtaagag
     3121 ataaaagaaa atatgatgtt cataatgaag acatattttt taaaacagta aaagcatcct
     3181 ttggacaaag aagaaaaact cttcttaatt cgttgggagg tcttggtttt cttaataaag
     3241 atgaaataag agaagtatta aaagaagcta atatagacga aaaaagaagg ggtgaaactc
     3301 ttagtataga agagttttca gttctttcaa atataataaa tacaaaagta tcttctaaat
     3361 agaaggtact ttttttaatt ttgttaacat atattgttta gagaaactgt gttaaggggg
     3421 gattgcagtg ggttctaaaa gaaagtttaa aagagactat ataatactag aagctaaaga
     3481 cataaacttt agatacaaag aacgagtact gccaaaagct tttgcaaaag ttgaagtaaa
     3541 tgatgaaaaa gcaattattg cattatatgt agaaaatcta aaatatgtta aagatgggta
     3601 taaagcagta gcaataaaag atgaccatgg attaatagac ttaggaaata taattttaaa
     3661 tgaacaagga agaggtgaat ttgttttaga tttagaagat tatgatgatg agataaaagg
     3721 tattgcatta ttgtatgaaa gaaatatacc tttaattgga tttaaaggaa ataagcttga
     3781 aaattatgag gacatattat ttcaagaggt agaggaagaa gaatatgaag aatatgaaga
     3841 gttggaagaa gaagacgaag agatagagga gaatgaggaa agtgatagag acgaagatag
     3901 tgaagaagaa tatattatag aagaatatga tgaagatgag tatgaagact attgggaaga
     3961 tgatgaagat attgaagaag gagagttaaa agcaagaacg gaagtagaag attctgatga
     4021 tgaggaaata gaagagttca ataattataa ggaaatagaa aattataata gggttaaagt
     4081 acaggaagaa tatatagaca tagaatatga tgaagaagaa gaggaagaag aagtttttga
     4141 agtaaataga gaagaagata ggtttgtttc ctcaaaacct actaaatcaa agaaagttca
     4201 aaaagatcag aataatattg aaaaaataaa aagagctaat ggagtaagtc aaggagagag
     4261 tggaaataaa caaaccagta cattacttat gccaagacaa ataaaaaaag gtttgaaatt
     4321 atttaaagaa gtaaaacctt ttgtaacaga ttatatagat aagacaagat ggtggaaaat
     4381 agagataaat cctacaacac tgtgtggata tacaatgcct tatttaggat atttaaacgt
     4441 attgaattac actatgtata gtgatgcagt tttacattca tataaataca gacactattt
     4501 atttggagtt cagtatgatg aatataataa gagaaaacat tatatttatg ctatcccagg
     4561 aaatagaaat gaacagccag acaatggaag cacaggattt ttaagatatc aagcttgtga
     4621 taatagaaca aatagtttag gatattggct atgttttata gattctagac aaagaaatat
     4681 agttaggtaa aaataataaa aatgaaaaaa tttagactca attcttattt tactgaaaaa
     4741 attaatgaaa tgtagtacaa aactttaaaa actattgata atatttaaat attacactac
     4801 aatatatctt gaaataccta ttatattatg gaggaaaatt atgataaacg agcaaagaat
     4861 tttaaatgag tttcttgaat tagtacagat agatagttta tctttaaaag aggggaatgt
     4921 tgctaaagta ttagttaaaa aattagaaga aataggttgt tcagtagtaa tagacaatgc
     4981 tggtgaaaaa gcaaatggag aaactggtaa tataatagct acattaaaag gaaataaaga
     5041 aggaaagaaa atattattta gttcacatat ggatacagta actccaggta taggggtaaa
     5101 acctatagtg gatgaagcaa atggaataat aaaaagtgat ggtactacaa tattaggttc
     5161 tgatgataaa gcaggtatag cagctatatt agaaggctta agatatataa atgaaaataa
     5221 catagaacat actgatatac aagttgtatt ctctatatgt gaggaatgtg gattagttgg
     5281 agctaaaaat ttagactatg gaaaaataga ttctgaatat gcatttatat tagatagtgg
     5341 tggttctcca ggtgaaataa tagtaaaagc tcctgcacaa gatgtaataa atgttaagat
     5401 attaggaaag actgctcatg caggtcttga acctgaagct ggaataagtg ctataatggt
     5461 agctgccaga gcaatagaaa atatgaattt acttagaata gacgaagaaa caactgctaa
     5521 cataggaatt ataaacggtg gaacagctac aaatatagta acaggagaag ttaatatagt
     5581 tgcagaagcc agaagtctaa aagaaaataa attagatgtt caaactaaac acatggtaga
     5641 gacttttgaa aaagctgcga aagattttgg agctcaaatt gagatagatg ttaatagagc
     5701 atacacacca atagatgtta gtgaggattc tgaaataata aaacttgcaa agaaggcttt
     5761 ttcaaactta ggtatagaag gtcatactga atctacagga ggaggtagtg atacaaatat
     5821 attaagtaag aatggtatcg aagctataac tttaggaatt ggtatgaaaa atgctcatac
     5881 actaagtgaa catatagcta taaaagactt atatgattct gctaaaatgg tagtggagat
     5941 aataaaggaa gcataaattt aaataatagt gtataatata tatatcgcct agcttaagct
     6001 aggtgatttt tcattttata gaagattgat aatctctatt gaaagcaaag agtatacatt
     6061 tgcatataag agagtgttta atttatgttc aaatgtaggt tcttaataat atttagattg
     6121 tttcataagg gaggaataaa tatggaaaca aggtatgaag aagcaaataa aataacaata
     6181 caatcaatac tttggaatat agtattaaca ataattaagg ttatagctgg tgttattggt
     6241 aattctagcg ctatgattgc ggatggatta cattcagcat cagatattat aagttctata
     6301 ggagtactaa taggcaatta tgtatcttct agacctggag atagagagca taattatggt
     6361 catgagaaag cagagacatt agtatcattt gtgttatcaa tattgcttat tttcgtttct
     6421 ataacaatag gtatagaggc aattaaatct ttatttaact tagatgcatt aagtgttcca
     6481 tcaatattac cattagtagt atcagttatt tcaatcctga taaaagagta tcaatataga
     6541 ataacaataa aagttgctaa aaagataaat tcaccagccc taaaagctga tgcttggcat
     6601 cacaggtcag atgctttatc ttcagtagct gcttttatag gtataggtgg ttctatttta
     6661 gggtttaaac cattagaccc aattgcgtca gttgtagtgg ctatatttgt agctaaagta
     6721 ggaattagta tacttataag ttctgttaat gaattgatgg atgtttcagt tgatgaagaa
     6781 gagataaaag aattaaaatt tattgtagca gatacagaag gtgttaaaaa tcttggtgat
     6841 ataaagacta gaaaacatgg agctatggca tatgtagatt tgactatatg tgtggatgaa
     6901 aatttgacag ttaagcaagg tcatgatatt gctaccaagc ttgaaaaaca tataataaaa
     6961 catatggaat ttgtaaaagg tataacagtt cacgttgaac catgtactaa ttgccaagga
     7021 aataagtgta ataattaatt aaaacttaaa aaaaagtgta aaaagttata taattgtttt
     7081 atgattataa actctagggg tggttaaatg agcaagaaaa gaaaactaaa gaaaaaagct
     7141 gcaatattaa taggagtagt tgttttcttt ataatatact ttatatcctt tagaatagga
     7201 ataaatatgg aaaaggataa aagtgaagtg ccaaagaagg tagaaaaaga agaagaagat
     7261 aataggtctt taaggactca aataaaagag aagaagaagg tttatatatc agataaaaat
     7321 atagaaaaca taaaaattga agaagatatg tgggatgaaa taaagttatt tttctcagat
     7381 tttaagaaag taagaaatac tacttcttct tacgaagcag tttatgaagg ttattctgat
     7441 gatggagtta aattttctac tgaccttaac ttttttagag tatatactgt aaataaagaa
     7501 gaatattata aagtaccagt tagttctaag gatgctttta agaaactttt agatgagagt
     7561 atatatactt cgtttgacct tttaagtcat tataaagatt ggaaagaggt tactataact
     7621 catggaaaag aaattaaaaa agttcataga tggaaatttg atgatttagc acataagatg
     7681 atttcaaaga gggttgtagg aaaagttcaa cctgagaaaa gtaaggaaag aagtgactat
     7741 aattttacta taaatataaa aggtgataat tttgatgtaa aagttgatac aatgggaaaa
     7801 gattatgtaa aagttacttc taagaaaaat gtatcttact atgaggttca tacaagttta
     7861 tttgattacc ttaaaaatga gatatttgaa attggaaaga aataagactt taagaaggct
     7921 atcaaattag atatttgata gcctaaatta ttttatatat tatttttcaa ccaacaagtc
     7981 tgcaacctta taaattggac cagcaccagc agttattact aaatcattat ccttaacatt
     8041 ttcacgtaag tattttacta tatcttcaaa ttcttttata tagatggcat ctacattgtt
     8101 ttgatataat ttctcaacca agtccttaga atgtatatct cctgggtctt tttccctagc
     8161 agcatatata tctgttatga taactttatc agcagcatag aatgcctctg aaaattcacc
     8221 taaaagagat tttgttctag tataagtatg tggctggaag atacaccata aagttgattt
     8281 ttttaatttt ttggcagcag ctaaagttgc ttttaactca gttggatgat gtgcataatc
     8341 atctactact aaagcattct tatagtaccc tttagtttca aatcttcttc cgacaccttt
     8401 ataaattttt atattttttc ttatagtctc taagtcaata ccagaaacaa gagctgccat
     8461 tatggcagaa gaagcattgt atatgttatg aagaccatat acagaaagtt caaattctcc
     8521 taaatctctt ccttcatatt ctattctaaa tattccatga ccactattgt caaagtgaat
     8581 atcttttatt acagcatcat tgtcagaatc tctgccgtat tttataatag tagctttaac
     8641 atcatacaat atgtcatcaa tattttcatc atcgccattt attatgaaat agccttctgg
     8701 gggtaataat tttccaaatt tgttaaaaga agccttgatt tcatctattc cagagaaata
     8761 atcaagatgg tcttcttcaa catttaaaac tatagatatc tttgggttaa aattaaggaa
     8821 actatctaca tattcacatg cttcagttat aaagtggttg gaattaccta tcttaacatt
     8881 accacctatc atacttaagt taccaccaac tagtatagtt gggtctaagt ctgcatattc
     8941 aaagattgta gataacatag atgttgtaga agtttttcca tgtgttccag aaactgctat
     9001 agaattttta tattccctca tgatttggcc taaaaaagtt gctctgttca ttaccaattt
     9061 atttttttct ttagcagcca caagttcttc attgtctgga tgaactgctg ctgtataaac
     9121 aaccatattt acatcatctg atatattatc ttttttctga ccaatataaa tagttgcccc
     9181 ttggtcccta agtttgtcta ataggtatga ttcgtttgaa tccgaacctg aaacttgata
     9241 acctttattg atacatattt cagctaatgc actcatgctg ataccgccaa ttcctataaa
     9301 gtgtatattc ataataaaac cacctttctt tttaattaag tcctacaata tgaactattt
     9361 ctgtggtata ataatataat gttcaatatt ttataattaa tatgcatata atattatatg
     9421 tattttattt ttgaatataa taaaacataa gtaatattat accacaataa gaattgttat
     9481 gcattagtta gtttaacgtt atataaaggt acttgtagga ggaaataata atgaaattta
     9541 aaagaacaga gagaattgga gcaatagtta aaatactgtc tgataatcca aataaaatat
     9601 atactttaag ttattttaca aatcaattta atgcagcaaa atcaacaata agtgaagatt
     9661 tattagttgt aaaaaatgta tttgagaagc tacatttagg taaagttata actatttcag
     9721 gagcagcagg aggagtaaaa tatataccta aaacttctat agcagaaaat gcagagttct
     9781 taatggaatt atgcgagaga atatgtgaca agtctagaat actatctggt ggttttttat
     9841 acttgattga cctaatttac gaccctacaa tagctgctaa gataggaaag atattcgcat
     9901 caaatattga gtatgtagat gcagattatg ttgtgacaat ggaaacaaaa ggtataccta
     9961 tggcacttat gactgcaaaa gctatgaatt tacctctagt tataataaga aaagatataa
    10021 aggtatcaga aggtcctaca cttagcatga catatgtgag tggaaacagt tctaaagttg
    10081 aaagtatgag tttgccaaga aaagctctta aaccagatag taaagttata attatagatg
    10141 atttcatgag gggtggaggt actataaaag gaatggtaga ccttatgaat gaatttggtg
    10201 cagaggttat aggtactgga gtattcatat ctacaacgaa tccttcagaa aaaatggtaa
    10261 aagattatat ttcattgatt caattggatg ttaatggaga taaaatagta gtagaaccaa
    10321 acttaaagac ttttaaagat gaatatagaa atgaagattt agacgaagaa gaagattcag
    10381 aatttgaatt tgagatagat gaagattaat aaaaaaaata tttagaaaaa tatgtaaaaa
    10441 taaaaagagg atatccctag ttgttcatag aattatttaa aaaacagttt atattaattt
    10501 attccagcga taataatttt aatataaatt aatttctgtc aaaatcaaag ggggatattt
    10561 tggtatgaag ataactgacg taagagtaag aaaattaaca gaagaaggta agatgaaatg
    10621 tatagtttca ataactttcg ataatttgtt tgtagtgcat gatataaaag ttatagaagg
    10681 ccataatggg ctatttatag caatgcctag cagaaaagta ggcgaaggaa atttcagaga
    10741 tatagctcat ccaataaatg cagaaatgag acaagtttta gaagatgcag ttttacaagc
    10801 gtatcatgaa gcattagttc aatgggaagt agctgctgaa taataataaa tatataaaat
    10861 ggagagagcc cgaacattta ggctcttttt aaatgtagaa tttctattaa aatatgtact
    10921 ttttagtaaa aaagtgctat attattagtg ataatgtata tgttgtatac aaattgttag
    10981 ataaatgtat tataatgtat attgattaag agaataatac gaataaaatt aaattagatt
    11041 gaatggagtg tatcaatgaa ctttaaagct ataatccttg ctgctggcaa aggaacaaga
    11101 atgaagtcta aatacccaaa agttatacat aaagtatgtg gaaaagaaat ggttaaccat
    11161 attatagatg tttcaaaaaa atcaggggta aaagatactg tcgtgatttt aggacatgaa
    11221 gctgatgtag ttaaagaaaa gcttgcagaa gaaattataa tagccatgca aacagaacaa
    11281 cttgggacag gacatgctgt aaagatggct aaagaatata ttaatgatga agatacaata
    11341 gttgtacttt gtggagatac tccacttata aaagaagaga cactaaagag actatttgaa
    11401 tatcatatag aaaataaata tcatgctaca gttcttacaa caagagttgg aaatccaaca
    11461 ggttatggta gaataataag agataagaag ggtgaccttc ttaaaatagt ggaacaaaaa
    11521 gatgcaaatt cagaagaaaa gatgataagt gagataaact ctggaattta ttgttttaat
    11581 ggaaagagtc ttagagaagc actagatttg ctaaataata acaattcaca aggtgaatat
    11641 tatttaactg atactgctaa aataatgaga gataaaggat taaaagttgg tgcatttgca
    11701 ggttcaacta ttgaagaact tatgggcgtt aattcaagag tagaattatc aaaggcagaa
    11761 gaaattatga gacgaagaat aaatgaatct catatggtaa atggagtaac tataatagac
    11821 actaactcta cctatataga atctgatgtt atgataggca atgatactat aatatatcca
    11881 ggtgttatgt tacaaggaaa aacaaggata ggttcagatt gtataattgg aatgaattca
    11941 tctataacaa attcagaaat aggtgatggt acagaaataa aaaattcaac tataattgat
    12001 agtaaggttg gagaaaattc tactgttggg ccatatgcat acttaagacc aaagagtgac
    12061 ttaggaaata atgtaaaaat aggcgatttt gtagaagtaa aaaatgctat tatagaagat
    12121 ggctcaaaag catctcacct ttcttatata ggagatgcac atgtcggtaa aaatgtaaat
    12181 attggatgtg gagtagtatt tgtaaactat gatggtaaaa ataaatttaa atcaatagta
    12241 aaagacaatg cgtttatagg ttcaaattct aatttagttg caccagtagt tgtagaagaa
    12301 aaaggatata tagcaacagg ttcaacaata acacatgatg tcccagatgg tgctttggca
    12361 atagcaagag aaagacaagt tatcaaagaa ggatgggtag aaaaaaagaa tcaaaaagac
    12421 gaccaaagta agtaattatg tagtttatta ttttggctaa aaaatttagc tcgaaattat
    12481 tataaattat attcattagt attttaaaat tttcaggagg gttacataaa tgaatactag
    12541 cggaagcgag attaaaatta ttgcaggtaa ttcatcgaaa gagttagcac aaaaaatagc
    12601 tgactatata ggtgtatcag tactagattg tgaagtaggt acatttagtg atggtgaaat
    12661 atgtgtaaac atgaatgaga cagtaagagg ttgtgatgtg tttgtagtgc aatctactaa
    12721 cagcccagta aatgataact taatggagtt attaatctta attgatgcgt taaagagagc
    12781 atcagcaggt agaataacag cagttattcc ttactatgga tatgcaagac aagacagaaa
    12841 ggctaaggca agagatccaa tcactgctaa attagttgca aatttaataa ctgctgctgg
    12901 agcagataga gtattaacaa tggatttaca tgcagctcaa atacaaggat attttgatat
    12961 accattagac cacttactag gtggaacaat attagcaaat tattttaatg aaaagaaaat
    13021 agaagattta gtagtagtat ctcctgactt aggaagtgtt actagatcaa gaaaatttgc
    13081 taatacttta aatggagaag ttccaatagc tataatagat aaaagaagac cgaaagctaa
    13141 tgtatgtgaa gttatgaact taataggtga tgttaaaggt aaaaatgtta tactattaga
    13201 cgatatgata gatacagcag gaacaatagt taatgctgca aatgcactta aagagtttgg
    13261 agcaaaagat gtttatgctt gttgtactca tggtgtgtta tcaggtccag ctattgaaag
    13321 aattgctaat tcagaaataa gtgagttaat agttcttgat actatacaac ttcctgaaga
    13381 gaaaagaata gataagataa agataaaaac agtagctcct ttatttggag atgctataag
    13441 aatgatattc tctaatgaat cagtaagtaa attattctaa tttattgtat ttatgagagt
    13501 tgtttaaaag gatataaacc ttttgagcaa ctcttttttg attttatact tatggaatgt
    13561 tatttttttc ttgttagaaa ggtatatatt attgtaaaaa gagattatag tttaaaatta
    13621 tgtatattta agtaaaataa acctaataaa gggtatatta ttcaaaatat tatgaatata
    13681 aaaaatatta caaaaaagta ttgaaaaaat tcagattatg tagtattatg taaatataaa
    13741 taaagaaaga ggtgtttcca atgggaaggt tagaagatga acccctaata attaaatgat
    13801 tcagtcacaa tctaaagtga atataaaaat ctattgaaag tttatttata agaattgaaa
    13861 atagtatcta ttctatcttt agtgtttgtg agagggttct ggattatata agattactgt
    13921 aaagagtaat tttgcacaat aagcatatct gtaaatgaag agtttcgttt atataatgat
    13981 tgtggctgaa tcataactat aatagataga atgtttataa tagatgattt tataaaatac
    14041 tatattgtaa tagcttttag ctttcaaata aatattagca aaggatggaa atgacaatga
    14101 taaaactaaa tgataattta taaatatctc cttacgatat ataataattg tagggagatg
    14161 tttctttttt tgtatagcat aatttttcta gaaattctgt ttcaatatgt aaaaagttgg
    14221 tatatataaa tagtataaac agtgttgcta aaatatggta gatattatat aatataagtg
    14281 gatatgtata tacattatga gttatataat ttgaatttaa taaaatagaa acgttgattt
    14341 atgttctgta atgtgggcac cttggagcat attgagttag tggtgcaacc ggctatgaaa
    14401 ttgtatttat ttataaatac tattattttc atagcttttt ttatttaaaa aatggttata
    14461 tgttagaaat aaatttggtt agtacgttta aataatttta cttagatttt taaccagata
    14521 tattgtaagt aagtattaat taaaaaattt aagggggaat aaaaatgaag ttaaaaaaga
    14581 ataaaaaagg tttcacttta gtggaattat tggtagtaat tgcaattata ggtatattag
    14641 cagtagtggc agttccagct ttatttagta atataaacaa ggctaaggta gcaagtgttg
    14701 agtctgatta tagttcagtt aagagtgcag cattatctta ttattcagat actaataaga
    14761 taccagttac accagatggt caaactggtt taagtgtttt agagacttat atggagtctc
    14821 tgcctgataa agctgatata ggtggaaaat ataaattgat taaagttggt aataaattgg
    14881 tattacagat aggtacaaat actgaaggag ttacattaac agaggcacaa tcagcaaagt
    14941 tattgagtga tataggtgaa aataaaatat atacaagcac tacaacaaat agtttgggaa
    15001 atccattaac aagtaataca aaaatagata ataacgttct atatatagta cttatagata
    15061 atactgtgat ggacacaaca aaatagttaa aacaatattt ttataaaaat
//
LOCUS       DAEQCW010000089        15087 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.090, whole genome shotgun sequence.
ACCESSION   DAEQCW010000089 DAEQCW010000000
VERSION     DAEQCW010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15087
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.090"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            206..784
                     /locus_tag="KRO40_002747"
     CDS             206..784
                     /locus_tag="KRO40_002747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2093560.1"
                     /translation="MGITLSKGQKVDLTKGNPGLKNILVGLGWDTNKYDGGFDFDLDT
                     AAFLTGASGSVTNDGDFVFYNNLKHTSGAVEHLGDNRTGEGDGDDEQIVVDLSKIPGE
                     ISKISFTVTIHDATERRQNFGQVSNSYIRIVDKDTNEELIKYELGEDFSIETAIVVAE
                     IYKHNGEWKFNALGSGFEGGLAALCGNFGINL"
     gene            823..1401
                     /locus_tag="KRO40_002748"
     CDS             823..1401
                     /locus_tag="KRO40_002748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2093561.1"
                     /translation="MAIVLKKGQKIDLTKGNPGLKNIKLGLGWDTNSFDSGYDYDLDV
                     SVFMVGESQRVEKDEDFIFYNNLKHPSGAVEHLGDNRTGEGDGDDEEILVNLETMPKH
                     IQKIAVTVTIYEAAERRQNFGQVSNSYIRVLNSENDEEILRYDLGEEFSIETAITVCE
                     IYKYNGEWKFSAVGAGFEGGLEALCRNYGLNV"
     gene            1487..2116
                     /locus_tag="KRO40_002749"
     CDS             1487..2116
                     /locus_tag="KRO40_002749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2093562.1"
                     /translation="MSINLSKGDKIDLKKSNPGLSNILVGLGWDPVQQSGGGFFKSLF
                     GGGQADIDCDASVFMLNQEGKLSGIKDLIYFGNLKSACKSVLHTGDNLTGEGTGDDEQ
                     ILVNLDKVPSNIHKLLFVVNIYNCVDRKQHFGMIENAYIRVEDQGNKKEIAKYNLSDN
                     YSEKTTLIVGAIYRKDGSWQFKAIGEGTKDAGLKEVMQNLDRIECAYGI"
     gene            2106..4865
                     /locus_tag="KRO40_002750"
     CDS             2106..4865
                     /locus_tag="KRO40_002750"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBH2093563.1"
                     /translation="MEFNNDIKYYNVDKEEVTKDLSVNPEKGLSESEVKTRREKYGLN
                     EFTPKEEGSFWDDLKESLSEPMIVILIIAAVVSAVIGETHDAIGIVGAIAIGIAIGMI
                     TEGRSKKAAEALSKLTENIEVKVLRDGEVHQISKSELVPGDIVYIETGDMVPADGRLI
                     ESINLKIREDMLTGESDDVSKKCDVVVSMEEIESKGAVVVQEPIPAKQINMVFGGTLV
                     AYGRGALVVTSIGDNSEMGKIAQNLSETDEQTPLQIKLGNLGGLIAKVSSAVAGLLFI
                     FMVFQMISKNVLNVDMSGILPFLESIDPVKTAFTVCVALIVAAVPEGLPTMINMTLAI
                     TMQKMAKINALVTKKEACETIGSVSVICSDKTGTLTENRMTVEVAYVDGRYIESSEEE
                     INSYFEENCMINSTADVEHNDGDIKYLGSATECALLLYYKNVDYRQVRKNSNIVAQNP
                     FTSDSKRMTSVIGQDNHHVLLSKGAPEVLLELCSHIQRGKDIVPLTENIKHEILEEIK
                     KLQIKSMRTLGFAYKEISQAEEEAAVTAESDAMNVSAMENNLVFSGFVGIRDPLRKDV
                     IESVNTANKAGVSVKMLTGDNINTARAIGEELGLLKNNMRVVEASYIDTLDDEELKQE
                     IQSISIVARSKPDSKMRIVSALQKSGDVVAVTGDGINDAPALSKADVGIAMGISGTEV
                     SKNAADIILTDDSFSTIVKGIKWGRGIYDNFQRFVQFQLTVNVIAFLVAIISQVMGQE
                     MPFTTIQLLWVNIIMDGPPALALGLEPVRDHVLNRKPVDRKANIISKSMVYTIVLNAF
                     YITAILMLQSTFNFLGVDEAHKGTVMFALFAFSALFNAFNCREFNADSIFPNFTHNKL
                     ALQIIVLTGIAQVIFTQLFQDFFNSVAMDFMTWVKVLCVAASVIVVNEVVKCIIRLVK
                     LKKTA"
     gene            4952..6514
                     /locus_tag="KRO40_002751"
     CDS             4952..6514
                     /locus_tag="KRO40_002751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YceG family protein"
                     /protein_id="HBH2093564.1"
                     /translation="MGDSKVFEKIFSSQSDRGNYTPSKGYLSYFISYIGLEDEVLYNL
                     EIFKTKQNIDSKKDIALFTDVIANPSDFDIINYFKSGLQKYRTSMEDVDINILGFEEI
                     DYKIKQAMDRVLKEEEKEFTNDRVKQNFIVKIMAWIKIYIGALDINKNEAPKVIFYGD
                     IKKHEVYLLLILYLAGFDVLYLNPNSKSNIDILKSERYNIEFEEANIIEEKISFEERV
                     ILGEKIDKSSVKKAFTVGAEASKRISEELLNDAGFIKPWQLQDRKIKNLLLSSTVDEI
                     SIYWNQPLKLRPGFKFNDAIVEAPNFLSKINGIYNDKNEYIKFLDLLRDSESSTFIEF
                     NGDVDRFSKAFTREAFSLSFLLDSKGAIDKNSVLNNKDYSISTLALNQQIMILEKVEE
                     LLEGSMFLNGLSGEDKIKGLFTVLHMDKKFVHMMNNFDYSLINPKLIIYMYKSIVFDK
                     EIVFLMLLLSKIGFDIIILCPGGENNIENVINNQLIDVHRLDKMVYDLKLNSLENDIP
                     LLKKIFGKRRRF"
     gene            6515..7651
                     /locus_tag="KRO40_002752"
     CDS             6515..7651
                     /locus_tag="KRO40_002752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBH2093565.1"
                     /translation="MGININSFSKDKNSVEVTENLPTAVQEENFDIMEYTNNKKNELR
                     KSKEVEALTSLIEVENPDTILQFGRKASEGVARVSDSLLNTIKLNRNEENSKMLVHLT
                     KIMDKFDLDDFQETKEPNFVQKLFKKANNAIEMMFQKYETLGGEVEKIQIELEQYERD
                     IALSNKQIGAMLNENFEFYNELQKYIVAGEMAIEEMDNEILPFFKQKSETSGDQMDVV
                     NYQELLKVYDMLNQRVYDLRIAENIAIQTIPMLRGMQHNNYGLIRKINSAFVVTLPVF
                     KQCLSQAILLKKQELQAKSLKALDDKTNELLLRNAQNVSTQSAQIARMAGTSSVQIET
                     LEKMYNTIKSGIDETMRIEENNRALIKDNTKRLEELNTTIIYNK"
     gene            7715..8791
                     /locus_tag="KRO40_002753"
     CDS             7715..8791
                     /locus_tag="KRO40_002753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HpcH/HpaI aldolase/citrate lyase family protein"
                     /protein_id="HBH2093566.1"
                     /translation="MKYFDYICKDDLERIFLKEPEDFSAKTEKDVLKYALGAFLYVPA
                     TQYNMIYKSIIGDVKGVRPLAICLEDAVGVNGELEAIENLRLILKNISNESITNKDGI
                     PLIFVRIKDVEQLLRIKEIIIKNSHFITGILIPKANSELIENCIEALDFMNLQDMYVI
                     PIVETKEFIYNEKKELSFTNLYNAILRHKSRILSIRVGITDILGMYGIRRDKNFSIYN
                     NLICSSFILDIITYLQRPELDIPISGGVSEFFDMTNKDIRNKYIEEILLDKYHGLIGK
                     TVIHPMQIQIVQALSTVSYEDFTDALDILDSTDSKYGVSKGVLGERMNETNPHFLWAK
                     KTLILSKIYGVLNKGVDYEELLKF"
     gene            8769..10007
                     /locus_tag="KRO40_002754"
     CDS             8769..10007
                     /locus_tag="KRO40_002754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="HBH2093567.1"
                     /translation="MKNCLNFNCEIDIIDNPLNLELNDFLDVGIRNNSKRRFLFISKK
                     LGKHLACKPSEMDNLGKLMATIYNEKNKEESNGTVIAFAETGTAVGHSFFDYLCGDYE
                     FIHTTREQFDELENLEFLEEHSHATDQNLYFGMLNNFKFGDEIILVDDEITTANTCMN
                     IIRKIQSIYPKKKYTICSILNWVSDENLSKVTRLERELDCKIDFVYLFKGNFKFYIDE
                     DIISNYNDNYSITKLETISSDKVNLVVNHIYVDLEDYIGNKKYVKYTGRFGINRREQF
                     RLKEIVKRESKKITMASKESLKNEKEKILFLGTEEFMYIPMLFAKEKENQYDIYYHST
                     TRSPIINIDKNNYPIKSKFMLKSFYNIDIQNYIYNIDKHNFSKCYLFVELNKSENSYL
                     EFIDIIKKTSIKELTIVCCS"
     gene            10061..11149
                     /locus_tag="KRO40_002755"
     CDS             10061..11149
                     /locus_tag="KRO40_002755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine protease StiP family protein"
                     /protein_id="HBH2093568.1"
                     /translation="MRDFSTYSKDDVIFLLKDISNLIEEEGNKERELKIQNGRHYSEM
                     IPIEYEVSEDYLNLYHEKLRENKDKLAFSIGVMCEKIIKKNGNDVVLVSLARAGTPIG
                     ILAKRYIRSKYNISLPHYTISIIRDKGIDMNAIEYIVKNHPSSKIQFLDGWTGKGTIS
                     KELEKACDELNVKFKKYFDSTLAVLADPAGYSGLYGIREDFLIPSACLNSTVSGLVSR
                     TVLREDLIGKNDFHGAKFYRHLKDKDESMNYIETIEECFKNQFKNISDEVENWESDII
                     TRDGYFDVLNIKEKYNITDINFIKPGVGETTRVLLRRVPYKILVKDLNDKSLDHIFIL
                     AKEKNVEVEQMDLKAYKCCGIIKNMKDI"
     gene            11177..11968
                     /locus_tag="KRO40_002756"
     CDS             11177..11968
                     /locus_tag="KRO40_002756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HBH2093569.1"
                     /translation="MIVFSDLDRSIIYSNKFLNADSKYTNIEIYREKEISYISLDTIN
                     LIKQIQYYGMFIPTTTRTVEQFKRIEFNKYGIYFPWSITSNGGVILKDNEILKSWSEK
                     IDKLKCDYEPIESMIHKFKDYLNVDGITNFKVAEDTFFYIVVDLSRFNLDSIKEYTNI
                     LESKNWKFYVSGRKIYFIPKEISKENAIKYLTKELGIEYFYAVGDSIMDYGMLNISNK
                     SYVLKHGDINKNEIENSFISSSFNGMSGTEEILSNILDENCLLNI"
     gene            complement(12083..12637)
                     /locus_tag="KRO40_002757"
     CDS             complement(12083..12637)
                     /locus_tag="KRO40_002757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH2093570.1"
                     /translation="MNIDVGSKIRSLRKSKNISISTLAKNSDLSTGLISQIERNMVVP
                     SIVAMWKISKALDINIGYFFEEIGREDSDIVVKKNNRKKIVTNDSTKFYELLVPNLSG
                     KKIEFILVTLDGHTQKNSEFVTHEGEECGYIIKGKMKITLGNKEYLLEEGDSFYFNST
                     IPHVYENYDDEVCISVWAMTPPSF"
     gene            12833..14035
                     /locus_tag="KRO40_002758"
     CDS             12833..14035
                     /locus_tag="KRO40_002758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 domain-containing protein"
                     /protein_id="HBH2093571.1"
                     /translation="MKSFVSPDNIWVLWAVVTGWAAFSIYLEQKYNWASKVSGAIIAL
                     VGAMLLSNLNIIPVESVVYDQVWGYVVPLAIALLLYQCNIKKIWKESGRLLIIFLVGS
                     VGTVLGAMIGFLALKNVVPDLNIVAAMMTGSYIGGNVNFAAMSGAFDAPGELVSATVV
                     ADNLLMALYFFVLIAIPSIGFFRKHFKHPHVDEMESIGITEGETVAANYWGRKEISLK
                     DIAIAIGSAFIIVAVSVELSTWFKAIIPLSNPFLAMLNTLFGNQYLIITTLTMLFATF
                     MPNFFGDIKGAQELGTFLIYIFFVVVGVPASITLIIQKSPLLLLYCGIMVLINMLVTF
                     IVAKIFKFSLEEAILASNANIGGPTTAAAMAISKGWSKLVGPILIVGTFGYIVGNYFG
                     LLVGNILI"
     gene            14092..15072
                     /locus_tag="KRO40_002759"
     CDS             14092..15072
                     /locus_tag="KRO40_002759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane dipeptidase"
                     /protein_id="HBH2093572.1"
                     /translation="MIFDGHSDTWADVTIRRLNGEKDVFRRIHLDNFKRANIEGAIFV
                     IWIDPPYDKEPEKRVKQIISSIKDEIEDMKDVVNIVKKYSDIDKGISENKINILIGLE
                     GLSHIGRNIDLLDYFYKEVGARHASLTWNEQNELATGCLGDENRGLSEIGKKAVNKME
                     KLGMIVDVSHLNEKSFWDLMSVASKPVIASHSNARSLCDAKRNLTDNQLKEISNTGGL
                     VGINSFRGFTNSNPKKQDLIHLVDHIDYMVNLIGIEHVSFGFDFSDYLGKETIGSFTG
                     NASVPSVDGLESTHTAQNIVVELENRGYKKKDIELISSGNFYRLFKDILK"
BASE COUNT         5945 a         1555 c         2743 g         4844 t
ORIGIN      
        1 tattaaacat agcttttata catttaataa ggtatgtaaa atctatgtaa aaagtaagaa
       61 atataaacat ttttttaatt atattttaaa aatatcaagc aagttttctt cacaaatgaa
      121 taaaaaatgt tataatatga ttaaagaaaa agataaataa ttagcaagat ttgtttagct
      181 aaaattaaca agggagcgat aaattatggg tataacatta tcaaaaggcc aaaaggttga
      241 tttaactaaa ggaaatccag gtcttaaaaa tattttagta ggtttaggat gggatactaa
      301 caagtatgat ggtggatttg actttgattt agatacagca gcatttttaa caggagcaag
      361 tggaagtgtt actaatgatg gagattttgt attttacaac aatttaaaac atacatctgg
      421 agcagttgag catctaggag ataacagaac tggcgaaggt gatggagatg atgaacaaat
      481 agttgttgat ttatctaaga ttcctggaga aataagcaag atttctttta ctgttacaat
      541 tcatgatgca acagaaagaa gacaaaattt tggacaagta agtaattctt atataagaat
      601 agtagataaa gacacaaatg aagagttaat aaagtatgaa ttaggagaag attttagtat
      661 agaaacagct atagtagtag ctgaaatata taagcacaat ggagaatgga agtttaatgc
      721 actaggttct ggctttgaag gtggtcttgc tgcattatgt ggaaactttg gaataaactt
      781 ataatttcaa ctataacaat aaactaaagg gggatatttt ccatggctat agtattaaaa
      841 aaaggacaaa aaatcgattt aactaaggga aatccaggtc ttaaaaatat aaaacttgga
      901 ctaggatggg atacaaattc atttgatagt ggctatgatt atgatttaga tgtaagtgtt
      961 ttcatggttg gagaatctca aagagttgaa aaagatgaag attttatatt ctacaataac
     1021 ttaaaacatc catctggagc agttgaacac ttaggtgata atagaactgg tgaaggtgat
     1081 ggagatgatg aggaaatatt agtgaattta gagacaatgc caaagcatat acaaaagata
     1141 gctgtaacag ttacaatata tgaggctgct gaaagaagac aaaattttgg acaagtaagt
     1201 aactcatata taagagtatt aaattctgaa aatgatgaag aaatattaag atatgactta
     1261 ggtgaagaat ttagtataga aactgcaatt acagtatgtg agatatataa gtataatgga
     1321 gaatggaagt ttagtgcagt tggagcagga tttgaaggtg gcttagaagc actttgtaga
     1381 aactatggct taaatgttta atttaagcaa tataatatat taaatataaa taacctatac
     1441 aaataatgta taggttatat tatataaaat tttgtggagg tttagtatgt cgattaattt
     1501 atcaaaaggt gataaaatag atttaaaaaa atctaaccca ggactgagta acatacttgt
     1561 aggtctagga tgggaccctg tgcaacaatc tggtggaggt ttttttaaat cgttatttgg
     1621 tggaggacaa gctgatatag attgtgatgc atctgtattt atgcttaatc aagaaggtaa
     1681 attaagtgga ataaaagatt taatttattt tggaaatcta aaaagtgcct gtaaatcagt
     1741 tttgcataca ggagacaatc taactggtga gggtacaggt gatgatgaac aaatcctagt
     1801 taatttggat aaagttccat caaatattca taaattattg tttgtagtaa atatatacaa
     1861 ttgtgtagat agaaaacaac actttggaat gatagaaaat gcctatataa gagttgaaga
     1921 ccaaggtaat aagaaagaga tagcaaaata caatctatct gataattatt ctgaaaaaac
     1981 tactcttata gtaggagcta tatatagaaa agatggaagt tggcaattta aagcaattgg
     2041 tgaaggaaca aaagatgcgg gtcttaaaga agtaatgcaa aatttagaca ggattgagtg
     2101 tgcatatgga atttaataat gatatcaaat attataatgt agataaagaa gaagttacaa
     2161 aagacttatc tgttaatcct gaaaaaggtt tatcagaatc agaagtcaag actagaagag
     2221 aaaaatatgg tttgaatgaa tttactccaa aagaagaggg tagtttttgg gatgatttaa
     2281 aggaaagttt aagtgaacca atgatagtta tcttgattat tgcagcagta gtaagtgcag
     2341 taattgggga aactcatgat gcaataggga ttgtaggtgc tatagcaata ggtatagcaa
     2401 taggtatgat tacagaaggt cgttctaaga aagcagcaga ggctctttct aagttgactg
     2461 aaaacataga agtaaaagta ttgagagatg gggaagtaca tcaaatttct aagagtgaat
     2521 tggtaccagg tgatatagta tatattgaaa ctggtgacat ggtacctgct gatggtagac
     2581 ttatagaaag tataaacctt aaaattagag aagatatgtt aacaggagaa tctgatgacg
     2641 tatctaaaaa gtgtgatgta gtagtttcta tggaagagat agaatctaaa ggagcagtag
     2701 tagtacagga gccaatacct gcaaaacaga taaatatggt gtttggtggc acacttgtag
     2761 cttatggtag aggagctcta gttgtaactt caattggaga taatagtgaa atgggtaaaa
     2821 ttgctcaaaa cttatcagaa acagatgagc aaactccact tcagataaaa cttggaaatt
     2881 taggtggttt gatagccaaa gtttctagtg cagtagcagg attactattt atatttatgg
     2941 ttttccaaat gataagtaag aatgtattaa atgtagatat gtctggaata ttaccgtttt
     3001 tagaatcaat agacccagtt aaaacagcat ttacagtatg tgttgcgttg atagttgcag
     3061 cagtgccaga aggtcttcca actatgataa atatgacact tgcaataaca atgcaaaaaa
     3121 tggctaaaat aaatgcattg gttactaaaa aagaagcttg tgaaacgata ggttctgttt
     3181 ctgtaatatg ttcagataaa actggtacat taactgaaaa tagaatgact gtagaagttg
     3241 catatgttga tggcagatat attgaaagtt cagaagagga aataaatagt tattttgaag
     3301 aaaactgtat gataaactct acagctgatg tagagcacaa tgatggtgat attaagtatt
     3361 taggaagtgc tactgaatgt gcattgcttt tatattacaa aaacgtagat tatagacaag
     3421 ttagaaaaaa ttctaatata gtagctcaaa atccttttac ttcagattca aagagaatga
     3481 cttctgttat aggtcaagat aatcatcatg tactattatc aaaaggagca ccagaagtct
     3541 tacttgaatt atgttcacat attcaaagag gaaaagacat agttccatta actgaaaata
     3601 taaaacatga gattttagaa gaaataaaga aattgcaaat aaaatcaatg agaactttag
     3661 ggtttgcata taaagaaatc tcacaagctg aagaagaagc agcagtaact gctgaaagtg
     3721 atgctatgaa tgtaagtgca atggaaaaca atttagtatt tagtggtttt gttggtataa
     3781 gagacccact tagaaaagat gttatagagt ctgtaaatac agcaaataaa gctggtgttt
     3841 ctgtaaaaat gcttacagga gataatataa atacggcaag agctataggt gaagagttag
     3901 gcctattaaa aaataatatg agagtggttg aagcttcata tatagatact ttagatgatg
     3961 aagaattaaa acaagagata caaagtattt caatcgtggc aagaagtaaa ccagatagta
     4021 aaatgagaat agtttcagct ctgcaaaaga gcggagatgt tgttgcagta acaggtgatg
     4081 gtataaatga tgctccagca ctttcaaaag cagatgttgg tatagcaatg ggtatatctg
     4141 gtacagaggt atctaaaaac gcagcagaca taattttaac tgatgatagt tttagtacca
     4201 ttgtaaaagg tattaaatgg ggtagaggaa tttatgataa cttccaaaga ttcgttcaat
     4261 tccaattaac tgtaaatgta attgcatttt tagtggctat aatatctcaa gttatgggac
     4321 aagagatgcc atttactaca atacaattat tatgggtaaa catcattatg gatggaccac
     4381 cagcactagc attaggttta gagccagtta gggaccatgt gttaaataga aaacctgttg
     4441 atagaaaagc caatataatt tctaagtcaa tggtgtatac aatagtatta aatgcatttt
     4501 atataacagc aatactaatg ttacaatcta catttaattt cttaggagtt gatgaagcgc
     4561 ataagggaac agtaatgttt gcgttatttg cttttagtgc actgtttaat gcatttaact
     4621 gtagagagtt taatgcagat agtatcttcc ctaattttac acataacaaa ttagcactac
     4681 aaataatagt gttgacagga attgcacaag taatatttac tcagctattc caagatttct
     4741 ttaactctgt agcaatggat tttatgacat gggtaaaagt tttatgtgta gcagcaagtg
     4801 taattgtggt taatgaagtt gtaaaatgta taataagact ggtaaaacta aaaaagactg
     4861 cttaaaacaa attttttaga agaaaacaga ctgactcaaa atatgaattt tgggtcagtt
     4921 ctgaataaac atttaaattg ggaggatagt tatgggtgac tcaaaggtat ttgaaaaaat
     4981 attctccagc caatcagata gaggaaatta cactccttca aagggatatc taagttattt
     5041 tatttcgtat attggtttag aagatgaagt tttgtacaat ctcgagatat ttaagacaaa
     5101 acaaaatatt gatagcaaaa aagatattgc tttatttact gatgttatag caaatcctag
     5161 tgattttgat attataaatt attttaaaag tggacttcaa aaatatagaa ctagcatgga
     5221 agatgtagat ataaatattt tgggatttga agagattgat tataaaataa agcaagcaat
     5281 ggatagagtg ttaaaagaag aggaaaaaga atttactaat gatagagtta aacaaaattt
     5341 tatagtgaaa ataatggcat ggataaaaat ttatatcggt gctttagata taaataaaaa
     5401 tgaagctcca aaagtaatat tttatggaga tataaaaaaa catgaagttt atttactctt
     5461 aatattatac ttggcaggtt ttgatgtttt atatcttaat ccaaattcaa agagtaatat
     5521 agatatttta aaatcagaaa gatacaatat agagtttgaa gaagccaaca taatagaaga
     5581 aaaaatttct tttgaagaaa gggttatttt aggggaaaaa atagataaaa gttctgtaaa
     5641 aaaagctttt actgttgggg cagaagcatc aaagcgtata agtgaggaat tgttaaatga
     5701 tgcaggattt ataaaacctt ggcaactcca agatagaaaa ataaaaaatc tacttctaag
     5761 ttcaactgtt gatgaaatat caatatactg gaatcaacca cttaaattaa gaccaggatt
     5821 taagtttaat gatgctattg tagaagctcc aaattttctt tctaagatta atggaatata
     5881 taacgataag aatgaatata ttaagttttt agatttatta agagattcgg aaagttcaac
     5941 atttattgaa tttaatggag atgtagatag attttcaaaa gcttttacaa gagaagcttt
     6001 tagtttatcc tttttattgg attcaaaagg tgcaatagat aaaaactctg ttttaaataa
     6061 taaagattat tccatatcaa cactagcatt gaatcaacaa attatgattt tagagaaagt
     6121 ggaagagttg ttagaaggaa gtatgttttt gaatggttta agtggagaag acaagataaa
     6181 aggtctattt acagtacttc acatggataa gaaatttgtt catatgatga acaatttcga
     6241 ttactcactt ataaacccaa aattgattat atacatgtac aagagtattg tatttgataa
     6301 agaaatagtt tttcttatgc ttttacttag taagattgga tttgatatta tcatattatg
     6361 tccaggagga gaaaacaata tagagaatgt tataaataac caattgattg atgtacacag
     6421 attggataaa atggtatatg accttaaatt aaattcgctt gaaaatgata tacctttact
     6481 taaaaaaatt tttggaaaga ggagacgatt ttagatgggg ataaatataa atagtttttc
     6541 aaaagataag aactctgtag aggttactga aaatttgcct acagcagttc aagaagaaaa
     6601 cttcgatata atggaatata caaataataa aaaaaatgaa ctgagaaagt ctaaggaagt
     6661 tgaggcattg acatctctta tagaagtaga aaatccagat acgattttac agtttggtag
     6721 gaaagcatct gaaggagtag caagagtttc tgatagcctt ttaaatacaa taaaattaaa
     6781 tagaaatgaa gaaaattcta aaatgttggt tcatttaact aaaataatgg acaagtttga
     6841 tttagacgat tttcaagaaa ctaaggaacc aaatttcgtt caaaaacttt tcaaaaaagc
     6901 taataatgcc attgaaatga tgtttcaaaa gtatgaaaca ttgggaggag aagttgagaa
     6961 aattcaaatt gagcttgaac aatacgaaag agatatagca ctttctaata agcaaatagg
     7021 tgctatgtta aatgaaaact ttgagtttta caatgaactt caaaaatata ttgttgctgg
     7081 agaaatggca atagaagaaa tggataatga aatactacct ttctttaaac aaaaatcaga
     7141 gactagtgga gaccaaatgg atgttgtcaa ttatcaagaa ctattaaaag tttatgatat
     7201 gttaaatcaa agagtctatg atttaaggat agcagaaaat atagctatcc aaacaatacc
     7261 tatgcttaga ggtatgcaac ataataatta tggtttaatt agaaaaataa atagtgcatt
     7321 tgtcgtaact ttaccagtat ttaaacaatg tttatctcaa gctatattac ttaaaaagca
     7381 agaattacaa gcaaaatctc taaaagcact tgatgacaaa actaatgaat tattgcttag
     7441 aaatgcacaa aatgtaagta ctcaaagtgc acaaatagct agaatggctg gaacaagttc
     7501 tgttcaaata gaaacattgg aaaaaatgta caatactatc aagtctggta tagatgaaac
     7561 tatgagaata gaagaaaaca atagagcttt aattaaggat aatacaaaga gattggaaga
     7621 attaaatacg actataattt ataataagta gtattatatt aagggctaat ttgtataaag
     7681 ttggcccttt ctatgtatat gaggaggcta gacattgaaa tatttcgatt atatctgcaa
     7741 agatgatttg gagagaattt ttttgaagga gccagaagat tttagtgcta agactgaaaa
     7801 agatgtgttg aaatatgcac tgggcgcttt tttatacgtt ccagctactc aatataatat
     7861 gatttataag agtattatag gggatgttaa gggagttaga ccattagcta tttgtttaga
     7921 agatgctgtt ggagtaaatg gagagttgga ggctatagaa aatcttagat taattttaaa
     7981 aaatattagc aatgaaagta taactaataa agatggaata ccactaattt ttgtaagaat
     8041 aaaagatgtg gagcaactgt tgagaattaa agagattata attaaaaata gtcattttat
     8101 aacaggaata ttaattccta aagcaaattc ggagttaatt gaaaattgta tagaagcttt
     8161 agattttatg aatcttcaag atatgtatgt tattccgata gtagagacaa aagaatttat
     8221 atataatgaa aaaaaagaac ttagttttac taatttgtac aatgctattt taagacataa
     8281 gtcaagaata ttaagcatta gagtaggcat aactgatata ttagggatgt atggtataag
     8341 gagagataaa aacttttcta tatataataa tttgatttgt tcttcattta tattagatat
     8401 aatcacatat cttcaaagac cagagttaga tatacctata agtggtggag tatcagaatt
     8461 ttttgatatg acgaataagg atataagaaa taagtatata gaagaaatat tattggataa
     8521 atatcatgga ttaattggaa agaccgtaat tcatccaatg caaattcaaa ttgtacaagc
     8581 gctatctaca gtatcatatg aagattttac tgatgctttg gatatactgg atagtacaga
     8641 cagtaagtat ggtgtgagca agggtgtatt aggagagaga atgaatgaaa caaatccaca
     8701 ttttttatgg gctaaaaaaa cattgattct atctaaaata tatggtgtat taaataaagg
     8761 agtagactat gaagaattgc ttaaatttta attgtgagat tgacattatt gataatccat
     8821 tgaatttaga actaaatgat tttttagacg taggaataag aaataatagc aaaagacgtt
     8881 ttttgtttat ctcaaagaaa ctcggtaaac atttagcatg taagccaagt gagatggata
     8941 atttgggaaa attaatggct acaatttata atgaaaaaaa taaggaagaa tcaaatggta
     9001 ctgttatagc ttttgctgaa actggtacag ctgttgggca tagttttttt gattacttat
     9061 gtggagatta tgaatttatt catactacta gagagcagtt tgacgagtta gaaaatctgg
     9121 aatttttaga ggaacattcc catgcaacag accagaattt atactttggt atgcttaaca
     9181 actttaaatt tggagatgag ataatattgg ttgatgatga gattaccaca gccaatacat
     9241 gcatgaatat aattaggaaa attcaaagca tttatcctaa aaagaaatac actatatgct
     9301 caatactcaa ttgggtaagt gatgaaaatt taagtaaagt tactcgttta gaaagagagc
     9361 tagattgtaa gatagatttt gtatacttat ttaaaggaaa ctttaaattt tatatagatg
     9421 aagatattat ttcaaattac aacgataatt atagtattac taaattagag actatttcaa
     9481 gtgataaagt aaatttagta gtaaatcata tttatgttga tttagaagat tatattggaa
     9541 ataagaaata tgtaaaatat acaggaagat ttggaattaa tagaagagaa caatttagat
     9601 taaaagaaat cgttaagaga gaaagtaaaa aaataactat ggccagtaaa gaatctttaa
     9661 aaaatgaaaa agaaaagatt ctatttttag gtactgaaga atttatgtat atacctatgc
     9721 tgtttgcaaa agaaaaagaa aatcaatatg atatatacta tcattcaaca acaagaagtc
     9781 caattattaa tattgataag aataattatc ctattaaaag taaatttatg ctaaagagtt
     9841 tttataatat agatattcaa aattatattt acaatataga taaacataat ttttctaagt
     9901 gttatttatt tgtagagctg aataaaagtg aaaattctta tctagaattt attgatataa
     9961 ttaaaaaaac aagtataaaa gaattaacta tagtatgttg tagctaaagt gttttaacag
    10021 gataaaatat atcacgattt taagatagga gttgagtcat atgagagatt ttagcacgta
    10081 ttctaaagat gatgttattt ttttattaaa agatatatca aatttaattg aagaagaagg
    10141 aaataaagaa agagaattaa aaatacaaaa tggtagacat tattcagaaa tgataccaat
    10201 agagtatgaa gttagtgaag attatctgaa tttatatcat gagaaactaa gagaaaataa
    10261 agataaactt gcattttcta taggagttat gtgtgaaaaa ataattaaaa aaaatggaaa
    10321 tgatgtagta ctagtttcac ttgctagagc aggaacacct attggtattt tggcaaaaag
    10381 atatataaga agcaagtata atataagttt acctcactat acaatctcta taataagaga
    10441 taagggaata gatatgaatg caattgaata tatagtaaag aatcatccga gctcaaaaat
    10501 tcaattttta gatggatgga ctggtaaggg aactatatca aaagaacttg aaaaagcatg
    10561 tgatgaactt aatgttaaat ttaaaaaata ttttgactca acacttgctg tattagctga
    10621 ccctgctgga tattcaggac tttatggaat tagagaagat ttcttaatac caagtgcatg
    10681 tttaaattca acagtttctg gtttagtaag tagaactgta ctaagagagg atttaattgg
    10741 taaaaatgac ttccatggag ctaagtttta tagacattta aaagataaag atgaatctat
    10801 gaactatatc gaaactatag aagaatgttt taaaaatcaa tttaagaata tatctgatga
    10861 agttgaaaac tgggaaagtg acattataac aagagatgga tactttgatg ttttaaatat
    10921 aaaagaaaag tataacataa cagatattaa ctttatcaaa ccaggtgtag gggaaacgac
    10981 aagggtttta cttagaagag ttccgtataa gattcttgtt aaagacttaa atgataaatc
    11041 tttagaccat atattcatat tagctaagga gaaaaatgtt gaagttgaac aaatggattt
    11101 aaaagcctat aaatgttgtg gaataataaa aaatatgaaa gatatttagg aaatatatta
    11161 gacaggagaa tattgaatga ttgttttttc agatttagac aggagtatca tttactccaa
    11221 taaattttta aatgctgata gtaaatatac taatatagaa atttataggg aaaaagaaat
    11281 atcttatata tctttagata ctataaattt aataaagcaa atacaatatt atggtatgtt
    11341 tatacctaca actactagaa cagtggagca atttaagcgt atagaattta ataaatatgg
    11401 gatttatttt ccttggagta taacttcaaa tggaggagtt atacttaaag ataatgaaat
    11461 attgaaatca tggagtgaaa aaatagataa actaaaatgt gattatgagc ccattgaaag
    11521 tatgattcat aaatttaaag actatttgaa tgtagatgga ataactaatt ttaaagttgc
    11581 agaagataca tttttttata tagttgttga tttatcaaga tttaatttgg attcaatcaa
    11641 agaatataca aatatattgg aatcaaaaaa ttggaagttt tatgtgagtg gcagaaaaat
    11701 atattttata ccaaaagaaa tttcaaaaga aaatgctata aaatacttga ctaaagaatt
    11761 aggaatagaa tatttttatg cagttggaga ttctattatg gactatggta tgcttaatat
    11821 ctcaaataaa tcctatgtat tgaagcatgg tgatataaat aaaaatgaaa tagaaaattc
    11881 atttatatca agttctttca atggaatgag tggaactgaa gagatactat ctaacatttt
    11941 agacgagaac tgcctactta atatataatg actgatatat aaataataaa ctagaaaaat
    12001 ctgaaataaa ttatagtaaa gtttatcata ctaatttatt tcagattttt atcaatttat
    12061 atttaagtaa gaactcaata tgttaaaatg aaggtggagt cattgcccag actgagatac
    12121 atacctcatc atcataattt tcatacacat gtggtatagt actgttaaaa taaaaactat
    12181 ctccttcctc caatagatat tccttatttc caagtgttat cttcatttta ccttttatta
    12241 tatagccaca ttcttctcct tcgtgtgtca caaattcact gtttttttgt gtatgaccat
    12301 ctagtgtaac aagtataaat tctatttttt tcccagataa attaggaaca agaagttcat
    12361 aaaattttgt agaatcatta gttactattt tttttcgatt atttttcttt actactatat
    12421 cagagtcttc tcttccaatc tcttcaaaaa aataacctat atttatatca agagcttttg
    12481 atattttcca cattgctaca atagatggaa caaccatatt acgctcaatt tgacttatta
    12541 agcctgtact taaatctgaa ttttttgcta aagtagagat acttatattt ttagattttc
    12601 taagagatct aattttgctt ccaacatcta tattcattag atacaaaccc cctcagacat
    12661 gattataaca tataatttat aaagattaat aaaataaaaa aaaagtttta caatacaagt
    12721 attttttatg ctatattgaa ttttctgaaa agatgcatta taatagtatt aatattcaat
    12781 atattgaata ttgataacga tattttaatt taatgaaatg gaggtaatta agatgaagag
    12841 ttttgtaagt cctgataata tttgggtatt atgggcagtt gtaactggat gggcagcatt
    12901 tagtatttat ttggaacaaa agtacaattg ggcatcaaaa gtgtcgggag caataatagc
    12961 tcttgtagga gcaatgttat tatcaaatct aaatattata ccagtagagt ctgttgtata
    13021 tgaccaagta tggggatatg ttgttccttt agccatagct ttattgttat atcaatgtaa
    13081 cattaaaaag atatggaaag aaagtggaag attgctcatt atatttcttg taggttctgt
    13141 aggaactgta cttggagcta tgattggatt tttagcatta aaaaatgtag taccagattt
    13201 aaatattgtt gcagctatga tgacaggttc ttatataggt ggaaatgtaa actttgctgc
    13261 tatgtcaggg gcgtttgatg cgccaggaga attagtatca gcaacagttg tagcagataa
    13321 tcttttaatg gcattatatt tctttgtctt aatagctata ccatcaattg gattttttag
    13381 aaaacatttt aaacatccac atgtagatga aatggaaagt ataggtataa ctgaaggaga
    13441 aacagtagca gcaaattatt ggggaagaaa agaaatatct ttaaaagata tagcaatagc
    13501 cattggtagc gcctttataa ttgttgcagt atctgtagaa ctatcaactt ggtttaaagc
    13561 tataatacca ttatcaaatc cttttttagc aatgttaaat actttatttg gaaatcaata
    13621 tctaataata actactttga ctatgttgtt tgccacattt atgcctaatt tctttggtga
    13681 tataaaagga gcacaggaat tgggtacatt tttaatatat atattctttg ttgtagtagg
    13741 tgttcctgct tcaataacat taataattca aaaatcacca ttactacttt tatactgcgg
    13801 aataatggta ctaataaaca tgctagttac atttatagtt gcaaaaatat ttaagtttag
    13861 tttagaagaa gctattcttg catctaatgc aaatattggt ggtcctacaa cagcagcagc
    13921 tatggcaata tcaaaaggat ggtctaagct agtagggcca atacttatag ttggaacatt
    13981 tggatacata gtcggtaatt attttggtct tttagtagga aatattttga tataatttta
    14041 cgtgaaaaaa agttgtttat tagaaagatt tttatttaat tggaggttgt tatgattttc
    14101 gatggacatt cagatacttg ggcagatgta acaataagaa ggcttaacgg ggaaaaagat
    14161 gtatttagaa gaatccatct tgataatttt aaaagagcaa atatagaagg agctattttt
    14221 gtaatatgga tagacccacc atatgataaa gagcctgaaa aaagagttaa acaaattata
    14281 agttctataa aagatgaaat tgaagatatg aaagatgttg taaacatagt aaaaaaatat
    14341 tcagatatag ataaaggtat aagtgaaaac aaaataaata ttttaattgg tcttgaagga
    14401 ttaagccata ttggaagaaa tatagattta ctagattatt tttataaaga agttggtgca
    14461 agacatgcat cattaacttg gaatgaacag aatgaacttg ctacaggatg tttaggggat
    14521 gaaaatcgtg gtttaagtga aataggcaaa aaagcagtca ataaaatgga aaaattgggc
    14581 atgatagtag atgtgtcaca tttaaatgaa aaatcatttt gggatttaat gtctgttgca
    14641 agtaagccag ttatagcttc tcattctaat gctaggagtt tatgtgatgc taaaagaaat
    14701 cttacagata atcaattaaa agaaatttca aatacaggtg gattagttgg aataaatagt
    14761 tttagaggat ttactaatag taatcctaag aagcaagatt taatacattt ggttgaccat
    14821 atagactata tggtaaatct tataggtata gaacatgtat cttttggttt tgattttagt
    14881 gattacttag ggaaagagac tataggttct tttactggaa atgctagtgt gccaagtgta
    14941 gatggtcttg aaagcacaca tacagcacag aacatagtag tagagcttga aaatagaggt
    15001 tataaaaaga aagatataga gttaatctct agtggtaatt tttataggct ctttaaagat
    15061 atactaaaat aatataataa agaactt
//
LOCUS       DAEQCW010000090        15080 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.091, whole genome shotgun sequence.
ACCESSION   DAEQCW010000090 DAEQCW010000000
VERSION     DAEQCW010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15080)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15080)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15080
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.091"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            8..910
                     /locus_tag="KRO40_002760"
     CDS             8..910
                     /locus_tag="KRO40_002760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBH2093573.1"
                     /translation="MLPQDYYGLIVILGVILGVMGAFYNWFTLYVQSLYKKIPKIGTF
                     GKLLIPFIMAGILGLVMPDVLGSGHNLVEELTSHKYIFGMVVLIFVIRFIFSAVSFGS
                     GAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMAGYFTAIVRAPLTG
                     IILIFEMTGSVSQMLSLSVISIVAYIVATLMKSKPIYESLLERLLEKNGEPVHKERGE
                     KILDQFSVMFGSPVANKAIQDVQWPENCLLVAIQRGGEEIIPRGKTILRPSDVIVTMT
                     DERDSGAVYDKMENLCKEHTAHIF"
     gene            complement(1589..2161)
                     /locus_tag="KRO40_002761"
     CDS             complement(1589..2161)
                     /locus_tag="KRO40_002761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="urea carboxylase-associated family protein"
                     /protein_id="HBH2093574.1"
                     /translation="MEYIINPCSGIKIKITRGQKIKIVDIEGGQVVDFFAEMKDDSTE
                     FISPGVTIDCNESLRLQVGNLIYSNKYRPMFKILYDDVREHDLLHPCCRPEMYDFFYH
                     NGENHPNCFDNINRTLGTSHQIIHPINFFMYTKVNTDGSIEVCEPLSKASDKIILEAL
                     ENMTLGIAACSVSESSCNSRKCTSIKILVD"
     gene            2564..3133
                     /locus_tag="KRO40_002762"
     CDS             2564..3133
                     /locus_tag="KRO40_002762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBH2093575.1"
                     /translation="MKKKLEDMTLEELWNLFPIFLTTHKECWKNWFKEEQYRLTGILP
                     MQKIVRISHIGSTSVSTIYAKPIVDILIEIIPDYNMKDIKDLIESNGYICMSESSSRL
                     SLNKGYTVDGFEERVFHLHIRYVGDNDELFFRDYLIDHPDVAKEYEKLKLDLWKKYEH
                     NRDAYTDSKLDFVREFTEKAKVLYSNRYN"
     gene            complement(3469..4806)
                     /locus_tag="KRO40_002763"
     CDS             complement(3469..4806)
                     /locus_tag="KRO40_002763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2093576.1"
                     /translation="MGTYSLISTSINFILILINIFIAFFLYTLTSYFIDFRNHWIFKI
                     ILILGYSIISQMIIWLSEPVNILFTLFGYFILLIICSKSKLIPIISVVMILYPIIIGL
                     NFLFINNPIYEELIHSKEYILILSIVQIISALIKLLFWFLIHIFLKNRLVNIKQYLSN
                     KIWIFIDMVCISSFLSILIAIILPPTNLIPMGSNKNIILGNLPYGTYLIILSAILANI
                     GVILLLQPLIENVKMKIEKQANHLKEKYYNLLENQQIQIRKMRHDMNNHFQMIESYLE
                     IEDIAGAKKYFNQLKIGIGTLSGKQFCKNQALNSILNLRHTSLEENGVDVHFNIDIDN
                     HLGIEPIDLCTIFSNSLDNAIEASLKIPDLSNRKVVLKARCEKEYFSYLLTNNKVNPI
                     NRKQELFISDKKDSNSHGYGIENIREIVNKYNGKLDISYTESEFSLFLYIRLF"
     gene            complement(5416..6126)
                     /locus_tag="KRO40_002764"
     CDS             complement(5416..6126)
                     /locus_tag="KRO40_002764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093577.1"
                     /translation="MTSICICDDEKQQRNMLNKIITREMDLWGYPYQIKEYSNGESLV
                     YNLEHENYYIDIIFLDIELGKSNGVDIAKTIRKHSKDTIIIFVTGFSDYVFHGYDVGA
                     LNYILKPYKTEKICKVLKEALKKLEQWKENFITVQIGTNLCKINTKDILYFKSELRKL
                     TVVTFDKTLEYYGKLNDMETVLPSNFIRTHQRYIVNLNHVDSITQTYAKVQNEKIPIS
                     RKKYQEVVGKFTRYMLES"
     gene            complement(6510..8621)
                     /locus_tag="KRO40_002765"
     CDS             complement(6510..8621)
                     /locus_tag="KRO40_002765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093578.1"
                     /translation="MTINKLYSKLRAYNWKNYTTLFFCIILSVVLVTSYALIYFSPTI
                     QNILPTGGDSRKQATMIFSVAILGCAVFTTYASSLFLKFKSKEIGIFMALGTDKKKLK
                     KLLFSEILLISIVCCFLGLILSIPVSFGIWKIFQLVIIDTREMTYHFGTQGFIYGFIF
                     SVFVTLCIFILSVKFINRTNIIDILNDQRISEPIQDVKDWYGILGIIFIILGIFLGYL
                     VPSLTINKLNYRLPSVWSFTYLLSLIGIYMIMTYIVVHAKRGKHPEKYYKNIISTSMM
                     RFMGRQTVKNMCVISFLIAGALFAVFYVPNMVTGIYDTLKNNPIDYTFTYNQRDKQVS
                     KKDIEQLADKHNIKIQNYMEIPSIELIVDGVESIYHKDGTIEKVYMKKSSYDMFFNSK
                     DFSKLIGKPITIKNGEYLAVVNKGNENQDYKYTKFISSPVTEKEIPFRYAGKIIFNGS
                     FFQNRSMNAYVLNDEDYKSFTKDLSIKNYNNSILFNVDKDTYAFANDLKKEIIKRTSK
                     EMGMFSGYDEYVKKRYESTGRKYFMDEEYPSGEGHLKLDPNNNQLYLNWKYYPNFKIL
                     QSQDMIKNMAVFLMLFIYVAIICFTAVGIIAYTRGVTIAINHKQVFMDLNRLGANNDY
                     IKFCIRNQLKKVFSYPLIAGSFLIYLFNFMIMLNNDGRIVNSEVNALLINLGFIGICG
                     VYMYLIYLLTYKKFKKIIGIL"
     gene            complement(8611..9363)
                     /locus_tag="KRO40_002766"
     CDS             complement(8611..9363)
                     /locus_tag="KRO40_002766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093579.1"
                     /translation="MLKVNQLCKSYKTGSKTYPVLKNISFEINKGEFVAIMGSSGSGK
                     TTLLNCISCFIPIDNGEIILGNNNIRNLKEKELSEVRNQQLGFVFQDFMLFDGLSVFE
                     NICVPQIIKGSQVLQMENRAINLCELFGIEHIRKKYPAEISGGEKQRTAVARALMNNP
                     DLILADEPTGNLDSKSCRTVIESFLKAKQELDATILMVTHDSFAASFCDRVIVLKDGI
                     IYKEVVKSNSRHKFLDELLEVLKEMGGAQDDN"
     gene            complement(10471..10647)
                     /locus_tag="KRO40_002767"
     CDS             complement(10471..10647)
                     /locus_tag="KRO40_002767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093580.1"
                     /translation="MFFTFIGVISAILLLCTIICGLWIKLNNRNNDSNSHFTFSILSI
                     AFSLLIVVAFLVRN"
     gene            complement(10751..11359)
                     /locus_tag="KRO40_002768"
     CDS             complement(10751..11359)
                     /locus_tag="KRO40_002768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093581.1"
                     /translation="MGKLLRGKIMKSDSTKEQLINATIQLLSSHRDVSSITAREIVAK
                     ANVNLAMINYYFKSKEELINISIKKFLKRHMDEYKATHDTKNLAPKQQLREILIAFFD
                     FIGEHSQFIKISVPYILIQEEIVYPFEILPLIKAHYENQNNKKTEAEYRTIAYQITSF
                     IQLLFLRSNAFFKYSGIDILNIEQRNGLIDFQLDLLLVDITK"
     gene            complement(11458..12282)
                     /locus_tag="KRO40_002769"
     CDS             complement(11458..12282)
                     /locus_tag="KRO40_002769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2093582.1"
                     /translation="MFKIGEVSKLTQISIRMLRYYDELGILKPAEIDKYTGHRLYSVE
                     QISILQRIVLLRDSKFSVAEIANIVHNWNDEFVIKELNRKKNEIQKEINQEQQRINKI
                     DKFIEAINCDKDEIHYNVVFKKIPSYKIISLREIIPDYQSEGILWEKLSKFIKEEHIE
                     VSRQSNNNIAFYHDEEVKDNGVDIEVGMVVKKIGKNKSGFIYRETEEIDMMACTMVYG
                     PYENIAGAYESFCYWLDKNSDYQISGINRQIGHKGEHNEINPENYLTEIQIPLIKV"
     gene            complement(12460..13353)
                     /locus_tag="KRO40_002770"
     CDS             complement(12460..13353)
                     /locus_tag="KRO40_002770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2093583.1"
                     /translation="MQLYNTPFNTNKHLIYFFTFTLVLNWIFSLTPALLGITNTILGE
                     IIFYLAYTSPAIVGLFFISTIYPQSAKQDFIYRYLSFKEIRIKWILLTILFFALTFIT
                     SLIIGNYFNVKTSDIDWIHIAVFRPSKIAYMLLASFILSILSQEAGWRGYAIDKLLVR
                     FGFIGSSIILGLVCGIWYLGSYFTPNQIPYNLAQYSLFDAFLFIPNIVLLNFIINFVY
                     INTSRSILSAGLVHMMYYFFNIQLLLHYPIKLCVIAQYVQIIFGLIFLVYMISSNKFK
                     QKVNSEIEQIKSDDFEFELDW"
     gene            complement(13610..14047)
                     /locus_tag="KRO40_002771"
     CDS             complement(13610..14047)
                     /locus_tag="KRO40_002771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="HBH2093584.1"
                     /translation="MKIHVEQGINCDDIEITIKCSALDNNIEKIISLLSTPLLDIKGK
                     KSGEIYKLNVCDILYFETVGNKTFAYYEDDVFEIDLKIYKLSKLLANTSFSRISKSMI
                     LNMDYIKSIKVISHNRMQATLKNNEKVIINRRYIKNIKEKLNI"
     gene            complement(14304..14453)
                     /locus_tag="KRO40_002772"
     CDS             complement(14304..14453)
                     /locus_tag="KRO40_002772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvrJ family protein"
                     /protein_id="HBH2093585.1"
                     /translation="MDDSLQLLITNVGFPIALSMYLLVRIEGKLNTLSNSIDTLSKNI
                     LIFKK"
     gene            complement(14466..14696)
                     /locus_tag="KRO40_002773"
     CDS             complement(14466..14696)
                     /locus_tag="KRO40_002773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2922 domain-containing protein"
                     /protein_id="HBH2093586.1"
                     /translation="MEIKKKLVMSFKNVKDKQVSFSIENPKDDLTEENIKSVMDLIVS
                     KNIFSVGGFDLASVVEAKVVETNTTPYDLVIE"
BASE COUNT         5431 a         1895 c         2065 g         5689 t
ORIGIN      
        1 tggaaatgtg ttgccacaag attattatgg attaatagtg attttaggtg ttattcttgg
       61 agttatgggg gcattttaca actggtttac tctatatgtg cagtctttat acaagaagat
      121 tcctaaaatt ggtacgtttg gaaaactgtt gattccattt ataatggctg gtattcttgg
      181 gcttgttatg cctgatgttc tggggagtgg acacaattta gttgaagaac ttacaagtca
      241 taaatatatt tttggaatgg ttgttttgat ttttgttata cgttttatat tttcggctgt
      301 tagttttggg tcaggtgcac cagggggaat attttttcca ttgcttgttt taggagcatt
      361 tataggtgga atatttggta tggtaggtgt taaagttttt ggaatgaatc ccgattatgt
      421 aaataacttt gtgcttttgg ctatggcagg atattttaca gctattgtgc gtgccccttt
      481 gactggtatc atattaattt ttgaaatgac aggttctgtt agtcaaatgc tttcactatc
      541 agtaatttca attgtggcat atattgtggc tacacttatg aagtctaaac ctatttatga
      601 aagtcttctt gagaggttac ttgaaaagaa tggagaacct gtacataaag agaggggcga
      661 aaagatacta gaccagttct ctgttatgtt tggctctcct gttgcgaaca aggcaattca
      721 ggatgtacag tggcctgaaa attgtctttt ggtagcaatt caaagaggtg gagaagaaat
      781 tattcctaga ggtaagacaa ttcttagacc aagtgatgta attgtgacta tgacagatga
      841 gagagatagt ggtgctgtgt atgataagat ggaaaatttg tgtaaagaac atacggcaca
      901 tattttttag ggataatgat gaatgtttaa taatgataga atatttaatg aagatttgat
      961 taaaaaattg gtaatttgaa agagagttaa ggaattaata taagaaaatg aaaatgtgat
     1021 atcttagata taaaagagtt tgaagaaaat aattgtatat atttgttaat gagattatat
     1081 ggactaatgg tatatttata ctgtgctaaa agttgcacta ttgtatgagg aatgggaata
     1141 aaaggtttga aaaaataggt agaagatttt tcagatattc ttattgggat attttaatta
     1201 atatatttta attacgatat tttgggaaga atagaattta tttataaatg aaaataatta
     1261 aaaggggtta agattagatg aataccagta agggtattat gagataatta acagttaaca
     1321 gctagagtgg ctatgaatac agtgtgtatt gcaagaaaaa ggtacacact gttttttcgt
     1381 tctgttacgc aataaaatgc tattttttag agtatgagta taaaatcctt actcatttgt
     1441 aattgtgtct gaaaaacatc atagaatcaa gggattttta cccataaata cgtaacaaac
     1501 cataatgaat tgagagcgca agtggttacc cttttgcgcc tttgacgtca ttttttaatt
     1561 ttgatatttt ttcgataaat gaaatttgtc aatcaaccaa aatcttaata gaagtacatt
     1621 ttctgctatt acaagaactt tctgaaacac tgcatgcagc aatccctaaa gtcatgtttt
     1681 ccaatgcttc aagaataatt ttgtcactgg cttttgataa aggttcacat acttcaatac
     1741 tcccatctgt attgactttt gtgtacataa aaaaattaat ggggtgaata atttgatggg
     1801 aagttccaag tgtgcgatta atattatcaa aacagtttgg atgattttct ccattgtgat
     1861 aaaagaaatc gtacatctca ggtctacaac atggatgtag caagtcatgt tcccttacat
     1921 catcatataa aattttaaac ataggtctat acttattaga atatattaaa ttcccaactt
     1981 gtaatcttaa tgactcatta caatcaattg taacacctgg agatataaat tcagttgaat
     2041 catctttcat ttctgcaaaa aaatcaacga cctgtcctcc ttcaatatcc acaattttaa
     2101 ttttctgccc tctagttatt ttaattttta taccactaca aggattgatt atatactcca
     2161 tatttaatgt cctccataaa ttccaatttg tcattctgtt ctatgttccc attttagcac
     2221 atactctgtt tcttttctat ctgtttctta atgttgataa catagtctat cattttttaa
     2281 ttctcataaa gatgttgtag tttttttaag attacagagt ttttttgctc ctatttggta
     2341 tttaagcaat cttactgtat ttagaagtaa gaaaaaatgt tctaatattt aaatagatac
     2401 aaaagtgtaa gaagggtaaa aatctgttat aatacattaa aaactaaatt tagaaaaatt
     2461 tacataatta gaaaaatgat ttgataaaaa ataaagttaa atattaacta agtaaatttg
     2521 aaaaagaaaa aatataaagt acaaatttaa agggaggtaa ctaatgaaaa agaagttgga
     2581 agatatgact ttagaggagt tatggaactt gtttcctata tttttgacta ctcacaaaga
     2641 atgttggaaa aattggttta aagaagaaca atatagacta actggaatat tgccaatgca
     2701 aaaaattgtt agaataagtc atattggaag tacttctgtg agtacgattt atgccaagcc
     2761 cattgttgac atactgattg agataattcc tgattataat atgaaagata ttaaagattt
     2821 gattgagtcg aatggatata tttgtatgtc tgagagcagt agtaggcttt cacttaataa
     2881 agggtataca gtagatgggt ttgaagaacg agtttttcat ttgcatataa ggtatgtagg
     2941 tgataatgat gagttgtttt ttagagatta cttaattgac cacccagatg ttgcaaagga
     3001 gtatgaaaaa cttaagttgg acctttggaa gaagtatgag cataatcgtg atgcttatac
     3061 agatagtaaa ctagattttg ttagggagtt tactgaaaag gcaaaggtgt tgtattctaa
     3121 tagatataat tagaaatagg tacaattaga tatttatctt atatatcgta ttatattttt
     3181 taagaaagta attaatagaa aaagggcttg tttcaaaatg gagagataaa tccctttttc
     3241 attgttgaaa ggataaaaat atatttgatt tcatgtaaaa aagagtgcct catcaactaa
     3301 aaagtttatt ttgagacaca cacattttta ctaaggtaaa taaaatatca catttgatta
     3361 aattttaagt taatgaatat atgtgtaaat atttaattat aagttattat aattttacat
     3421 agtatcaaac aatctaattt gtattatata agataatcta attttagact aaaataatct
     3481 aatataaaga aataaagaaa attcactctc agtataagaa atatccaatt ttccattgta
     3541 cttattaaca atttctctaa tattctcaat accatatccg tgagaattac tatctttttt
     3601 atctgaaata aatagttctt gttttctatt gataggattt actttgttgt ttgtcaataa
     3661 atagctaaaa tactccttct cacaacgtgc ctttaatacc acttttctat ttgacaaatc
     3721 aggaattttc aaagatgctt ctatagcgtt atctaaagaa tttgaaaaaa tagtacataa
     3781 atctataggt tctataccca agtgattgtc tatatctata ttaaagtgca catcaacacc
     3841 attttcttcc aaacttgtat gacgaagatt taaaattgag ttaagagctt ggtttttgca
     3901 aaattgtttg ccactaagag tacctatacc tatttttaac tgattaaaat actttttagc
     3961 tccagcaata tcttcaattt ctaaatacga ttcaatcatt tgaaagtgat tattcatatc
     4021 atgtcgcatt ttgcgtattt gaatttgttg attttctagt aagttatagt atttttcttt
     4081 taggtgattt gcttgttttt ctatcttcat ctttacattt tcaatcaatg gctgtaaaag
     4141 aagtatcaca ccgatatttg ccagaattgc tgacaagatg attagataag tgccataagg
     4201 taagttgcct aagataatat tcttattact acccataggg attaaattag taggtggcag
     4261 aataatagca attaatattg ataaaaatga agatatacat accatatcaa taaaaatcca
     4321 tattttattt gataagtatt gttttatatt gaccaatcta ttctttagga aaatatgtat
     4381 taaaaaccaa aataataatt taattagagc agaaattatc tggactattg aaagtattaa
     4441 aatatactct tttgagtgta taagttcctc atatataggg ttgtttataa aaagaaaatt
     4501 aagcccaatt ataataggat aaagtatcat gacaactgat attataggaa ttaatttgct
     4561 tttgctacat attataagta gtataaaata tccgaatagt gtaaacaaaa tatttacggg
     4621 ttcggaaagc catattatca tttgactaat aatagagtag cccaaaatca atatgatttt
     4681 gaaaatccaa tgattcctaa agtctataaa ataggaagtc aacgtataaa gaaaaaaggc
     4741 tatgaaaata ttgattaata ttagaataaa atttatgctt gtagagatta aagaataagt
     4801 gcccatttaa tatacctttc tattaattaa gattctggaa actaagtttt aaaaaattaa
     4861 atcttaaaaa ttaaaattct ggaaattaga tttcaaagaa ttgattttga aaaataaaat
     4921 tctagaaatt aagcttcaaa aaattgagtt ttaaaagatt gaaattttaa aaattaagtt
     4981 tcaaaaaatt aaatttgaaa aaaactctaa aaactaagct tcaaaaaatt gaattttgaa
     5041 agattgaaat tttaaaaatt aagtttcaaa aaattaaatt tgaaaaaaaa ctctaaaaac
     5101 taagcttcaa aaaattgaat tttgaaagat tgaaattcta gaaactaagc tttaaaaaat
     5161 taagtttgaa aaaaactcta aaaactaagc ttcaaaaaat taaattttga aagattgaaa
     5221 ttctagaaac tgagctttaa aaaattaagt ttgaaaaaaa ctctaaaaac taagcttcaa
     5281 aaaattaaat tttgaaagat tgaaattcta gaaattaatc ttcaaaaaat taaatttgaa
     5341 aaaacaaaac tctaaaaact aagctttaaa aaattaagtt tcaaaaataa aattctagag
     5401 attgaacttc aaaaattaag attctaacat ataccttgta aattttccta caacctcttg
     5461 atatttttta cggcttatag gaattttttc attctgaact ttggcataag tttgagttat
     5521 actatctaca tggtttagat tgacaatata cctttgatgc gtacgtataa aattagaggg
     5581 aagaacagtt tccatatcat ttaattttcc gtagtattct aatgttttat caaaggtaac
     5641 tacagttaat tttcttagct cacttttaaa gtagaggata tcttttgtat taattttaca
     5701 aagattagtt ccaatctgaa ctgtaataaa gttttctttc cattgttcta atttttttag
     5761 tgcttctttt aatactttac atattttttc agttttataa ggttttaaga tgtagttcaa
     5821 tgctcctaca tcatatccat gaaatacata gtcagaaaaa cctgtgacaa agatgattat
     5881 agtatccttt gaatgttttc gtatagtttt tgctatgtca acgccattac tttttccaag
     5941 ttcaatatct aaaaaaataa tatctatgta ataattttcg tgttctagat tgtatactag
     6001 actttctcca tttgaatatt cttttatttg gtaggggtag ccccacaaat ccatttctct
     6061 tgtaatgatt ttattcagca tgtttctttg ttgtttttca tcatcacaaa tacaaatcga
     6121 agtcaatttt ttatctcctt tcaaatttta tatttatata gttaagtata taatatattt
     6181 tgctacctag atatataaaa tgaaataaca attatatcca gatagcaaaa taaaattttt
     6241 tatattagta tacttacact taaaactatt ctattaaact tattctgaag tgctaatgat
     6301 tttcttatta aaaaatctaa caatctttct tattataaaa tacaaatgct tttattatta
     6361 taaaaagtaa tgattttatt actttaaaaa tctaataacc tttcttatta taaaacacca
     6421 atgattttat tactttaaaa atctaataac cttttttatt ataaaacacc aatgatttta
     6481 ttactttaaa aatctaataa ccttttttat tataaaatac caataatttt tttgaatttc
     6541 ttataagtta atagatatat aaggtacata taaaccccac aaatccctat aaaacctaag
     6601 tttatcaaaa gagcattgac ctcactattg acgattctac catcattatt taacataatc
     6661 ataaaattaa acagataaat taaaaaactt cctgcaataa gagggtatga aaatactttc
     6721 tttaattgat ttctaataca gaactttata taatcattgt ttgctcctaa tcgatttaaa
     6781 tccataaaga cctgcttgtg atttatagct atagtaacac cccttgtata tgcaatgatt
     6841 cctactgctg taaaacatat gattgccaca tatatgaata acattaagaa gactgccatg
     6901 ttttttatca tatcttggct ttgtaaaatt ttaaagttag gatagtattt ccaattaaga
     6961 tacaactgat tgttgtttgg gtctagtttt aaatgacctt caccacttgg atattcttca
     7021 tccataaaat attttcttcc agttgattca taacgttttt ttacgtattc atcataacca
     7081 ctgaacatgc ccatttcctt agatgttctt tttataattt ctttctttaa gtcattggca
     7141 aaagcatagg tatctttatc tacattaaat agtatagaat tattgtaatt ttttatggat
     7201 aaatctttag taaatgattt ataatcctca tcattaagga cataggcgtt catacttcta
     7261 ttttgaaaaa aagaaccatt aaatattatt tttccagcat atctaaaggg gatttctttt
     7321 tctgtgactg ggcttgatat aaatttggta tatttataat cttgattttc atttccttta
     7381 tttacaacag caagatattc accatttttt atagttattg gtttgccaat tagcttggaa
     7441 aaatctttag aattaaagaa catatcatag gagctttttt tcatatatac cttttcgata
     7501 gttccatctt tatgatatat tgattctaca ccatcaacaa ttaattctat agaaggaatt
     7561 tccatatagt tttgaatttt tatattgtgt ttatctgcta attgttcaat atcttttttt
     7621 gatacctgtt tatctctttg attgtaggta aaagtataat ctatagggtt atttttaaga
     7681 gtatcataga tacctgtaac catattagga acatagaata cagcaaataa tgctcctgca
     7741 atcaaaaatg aaataacaca catgtttttt actgtttgtc ttcccataaa tctcatcatg
     7801 ctagttgata tgatgttttt atagtatttc tctggatgtt ttcctctttt agcatgtaca
     7861 actatgtatg tcataatcat atatattcca ataagagaga gtagataagt aaagctccat
     7921 acagatggta gtctataatt taatttgttt atagttagtg aaggtacgag atatcctaga
     7981 aaaataccga gtataataaa aattatacct aatataccat accagtcctt tacatcctgt
     8041 attggttcag atattctctg gtcatttaat atatcaatta tatttgtacg attaataaat
     8101 tttacagaaa gtataaatat gcataatgtc acaaatacac taaatataaa tccatatatg
     8161 aatccttgag ttccaaaatg atatgtcatt tctctggtat caataatcac taattgaaat
     8221 attttccata taccaaaaga tacaggaata cttaatataa gacctaaaaa acagcatact
     8281 attgaaatta acaatatctc tgaaaataga agttttttta atttcttctt atctgttcct
     8341 agagccatga aaataccaat ttccttgctt ttaaatttta aaaagaggga agaagcgtat
     8401 gtagtaaaga cagcgcatcc taatatagca actgagaata tcattgtagc ctgttttctg
     8461 ctatctccac cagttggaag tatgttttgt attgttgggc taaaataaat tagagcatat
     8521 gaagttacta ataccacaga aagtattata caaaagaata aagttgtata gttcttccaa
     8581 ttataggctc gaagtttact gtataattta ttaattgtca tcttgagcgc ctcccatttc
     8641 ttttaaaact tctagtaatt catctaggaa tttatgtctt gaatttgatt ttacaacttc
     8701 tttataaatt attccatctt taagcacaat aactcggtca cagaagcttg ctgcaaagct
     8761 atcgtgtgta accatgagta tagtagcatc taattcttgc tttgctttta aaaatgattc
     8821 aatgactgta cgacaagact tactatcaag gttaccagtt ggttcatctg ctaatattaa
     8881 atctgggttg ttcatgagtg ctcttgctac tgctgtacgc tgtttttctc caccagatat
     8941 ttcggcaggg tatttttttc tgatatgttc aataccaaat agctcacata gattaattgc
     9001 acggttttcc atttgtaaga cttgactacc tttgataatt tgtggaacac atatattttc
     9061 aaagacacta agaccatcaa atagcatgaa atcttggaat acaaatccta gttgttggtt
     9121 tctaacttct gaaagttcct tttcttttaa atttcttata ttattatttc caagaattat
     9181 ttccccatta tcaattggga taaaacatga aatacaattt aaaagagtag tttttccact
     9241 tcctgatgaa cccatgattg cgacaaattc tcctttgttg atttcaaaag aaatattttt
     9301 taatacagga tatgttttac tacctgtttt atatgattta cataattggt ttactttaag
     9361 catatatatc atcctcactt tcatttatct tgtaagtcaa tgatagcatt tgaaagggga
     9421 ggagggatat gagctatatt gtaatagttg gatgtttttt tgtaatgttt gaaaatatat
     9481 tgtttggata gtgtgagagg ttattattat agttaaattg attatattat tggaggattt
     9541 agagggttat ttttaggtat taattgttgt ggtaaagtaa tatgatgtgg aacattgaag
     9601 gtgtagttag aaaaaaggta tatagtaaaa gtaaaaaggt tatagaataa cgaatgttgt
     9661 attgaaaaaa atgatgtaaa taatgtatag tagggttaaa aagaaaaaaa gaattataga
     9721 gcagtaagat tatttaatgg aatgtattgt aaataatttg aaaggattta ggggttatta
     9781 acacaatgta attgagaaaa tatattggag ttttggaaat aaataggttg ttaaaaacaa
     9841 ttgaaattta taataaaaag gttgaaaagt attattagta taggtatgat agataatttt
     9901 agaaagtgga agtattttag actatgctga aaagtgattg atattatttt gagatattaa
     9961 aatattacta tattatagta aagaagttaa aataataaaa tgttgtaata ataaaggttt
    10021 gtagtataat aaagaactgt aataaataag actttgcaat gtaacagaaa tgctgtaata
    10081 ataaaagtct gtagtataat aaagaactgt aataaataag agattgtaat aataaaagtc
    10141 tgtagtgtaa taaagaactg taataaataa gactttacaa tataatagaa atgttgcaat
    10201 aacaaaacac cataataaat aagagtttgc aatataatag aaacactgca ataaataaga
    10261 gattgtaata taacaaaatc ctataataaa taagatttta caatataata aaaatcctat
    10321 aataaatagg actctgtaat ataataaaat gctgtaacaa caaaacacta taataaataa
    10381 gaccctgtaa tataataaaa atactataat atagtaaaaa tcatgcaata ataaaaatct
    10441 ataataataa acctcagcat aacaaagaca ttaatttctt actaaaaagg ccaccacaat
    10501 taacagtgaa aaagcaattg aaagtattga aaaagtaaaa tgagaattag agtcattatt
    10561 acgattatta agttttatcc ataaaccaca tataattgta cacaacaata aaattgctga
    10621 tattactcct ataaatgtaa aaaacattaa aattcctccc ccttatttaa tgcaagtatt
    10681 tttagtcaat gagaatattt tcaaacgtta ccataaaata aaaaaatgta cataaaaaat
    10741 taatatagta ttattttgta atatctacca ataataaatc taattgaaaa tctattaaac
    10801 catttctctg ttcaatatta agaatatcaa taccactata cttgaaaaaa gcattagaac
    10861 gaagaaaaag caactgaata aatgaagtta tttgatacgc aatagttctg tattcagctt
    10921 cagttttttt gttattctga ttttcatagt gagccttaat taaaggtagt atctcaaatg
    10981 gataaacaat ttcttcctgt atcaatatat agggtacaga aatctttata aattgactat
    11041 gttcacctat aaaatcaaaa aatgcaatta gtatttccct taattgctgt ttaggtgcta
    11101 aatttttagt atcatgtgta gccttatatt catccatatg acgctttaaa aattttttaa
    11161 tagaaatatt aattaactcc tctttagatt taaaataata attaatcata gctaaattga
    11221 catttgcttt agctacaatt tctctagccg taatgcttga aacatctcta tgtgaagata
    11281 gtaactggat tgtggcatta attaattgtt cctttgttga atctgatttc ataatttttc
    11341 cccttaaaag tttccccata aaaaaattaa acatgtttaa cacacgttta gatactatca
    11401 tgaaaatttt gggatgtcaa tgggtgatta gtacttaagt atttaagtac taatctatta
    11461 gacttttata agggggattt gaatttctgt aagataattt tcaggattta tttcattatg
    11521 ttcaccttta tgtccgattt gtctatttat acctgatatt tgataatcac tatttttatc
    11581 taaccaataa cagaacgatt catatgcacc agctatattt tcatatggac cataaaccat
    11641 agtacatgcc atcatatcaa tttcttctgt ctcacgatat ataaatccag atttgttctt
    11701 tccaatcttc tttacaacca ttccaacttc aatatctaca ccattatctt tgacttcttc
    11761 atcatggtaa aaagctatgt tattgttgga ttgacgtgat acttctatat gttcttcttt
    11821 gataaattta gatagctttt cccagagtat accttcagat tggtagtctg gaattatctc
    11881 tctaagtgat atgattttat aacttggaat ctttttaaag acaacattgt aatgaatttc
    11941 atctttatca cagtttatag cttctataaa tttatcaatt ttatttattc tttgttgttc
    12001 ctgatttatt tccttttgta tttcattctt ttttctattc aattctttaa ttacaaattc
    12061 atcattccaa ttatgtacga tatttgctat ttctgcaacg ctaaattttg aatctctcaa
    12121 taatacaatt ctttgtagta ttgaaatctg ttcaactgag tataatctat gacctgtata
    12181 tttgtctatt tctgcaggtt ttaaaatacc aagttcatca taataacgca acatacgaat
    12241 agaaatttgt gttagttttg aaacctctcc tattttaaac atgaaaatat gacctccttt
    12301 tcacttataa tcagtatata ttttgttttt atatacttca agcgtttgtg gaaatacaat
    12361 tattttccag atgttgcaat aaattataga gagtaaatta tatttaagta gtaatcgtat
    12421 caaatcatag attatcttaa tttataattc atattaaaat taccagtcta actcaaattc
    12481 aaaatcatcc gactttatct gttcaatttc agaatttacc ttctgtttaa atttattaga
    12541 agaaatcata tatacaagaa atattaaacc aaatattatt tgtacatatt gagctattac
    12601 acataattta atagggtagt gtagaagtaa ttgaatgttg aaaaaatagt acatcatatg
    12661 aactaaccca gctgataaaa tgcttctact tgtattgata tatacaaaat taattataaa
    12721 gtttaaaagt acaatgtttg gtataaataa aaaagcatca aatagggagt attgtgccaa
    12781 attatatggt atttgattag gtgtaaaata cgaccctaga taccagattc cacaaacaag
    12841 ccctaaaata attgaagagc ctataaatcc aaatctaact aataatttgt caatggcata
    12901 tcctctccat ccagcttctt gactaagtat actcaatata aaacttgcta atagcatata
    12961 agctatttta gaaggtctaa acactgctat gtgtatccaa tctatatcag aagtttttac
    13021 attaaagtaa tttccgatta ttaacgaagt aataaaagtt aaagcaaaaa ataatattgt
    13081 taatagtatc cattttattc taatttcttt aaagcttagg tatctataaa taaaatcttg
    13141 ttttgcactt tgtggataga ttgtagaaat aaaaaataga cctacaatag ctggtgatgt
    13201 atatgcaaga taaaaaatga tttctccaag tattgtattt gtaattccga gcaacgcagg
    13261 tgtaagactg aatatccagt tcaatactag cgtaaatgta aagaaataga ttaagtgttt
    13321 gtttgtatta aagggggtgt tatatagttg cattttttca ctatccttcc gttttataat
    13381 gaagttttaa tttttattaa ttgtttattt atttttatat gtattaagtt atcgcttgat
    13441 gttagttatt gcctataata atatcctatt ttttatattt tgattaatta tttttacact
    13501 aaatataatt aattagtatt taatattgaa tatattatat tattattaat tattaaatag
    13561 gtcaataaat ttgcaattag tgatattaat aaattacttt agatttttat taaatgttta
    13621 gcttttcttt aatatttttt atataacgac gatttataat aactttttcg ttgtttttta
    13681 aagtagcttg catgcgatta tgtgatatta cttttatact ttttatgtag tccatattta
    13741 aaatcatgga tttagatatt cgtgagaagg atgtattagc taataatttt gataatttat
    13801 atatttttaa atcaatttca aatacatcat cttcataata agcaaatgtt ttatttccaa
    13861 ctgtctcaaa gtataaaata tcacagacat tgagtttata aatctctcct gattttttac
    13921 cttttatatc aagtaacggt gtactcaata atgaaattat tttttcaatg ttattatcta
    13981 gagcagaaca ttttatggtt atttcaatat catcacaatt aataccttgt tcgacatgta
    14041 ttttcattaa tcatcacctc attttattac tgtcattaga atagcattat atcttattga
    14101 gtccaactag atgcgttcta aatttcaaat taagcatagt gaaattcaaa aataaaacag
    14161 tgaaattcaa atttgaggtg gtaaaattca aaaaaatact atggatattt ggataaatta
    14221 tccaaatatc ctagtatttc acatagaata tgtctaatta ttttacaaat agacctattt
    14281 tatgacttac atatattgtc aaattacttc ttaaatatca aaatattttt ggataatgta
    14341 tcaatactgt ttgataaagt atttaattta ccctcaattc taaccaataa gtacatggat
    14401 agagctatag gaaaaccaac attggttatt aacagttgta aactatcatc cataaaatta
    14461 gccccctatt ctataactaa gtcataagga gtggtatttg tttccacaac cttggcttca
    14521 acaacagaag ctaggtcaaa tcctccaacc gaaaaaatat ttttagatac tatcaaatcc
    14581 atgacagatt ttatattttc ttcagttaaa tcatcctttg gattttctat agaaaaagaa
    14641 acttgtttat cctttacatt tttaaagctc atgactaatt ttttcttaat ttccatataa
    14701 ttacctccga tataataatt tatattttaa ttgtttgctt gttaatattg gtattttaat
    14761 tgtcaatatt aatgttttgc ttgttagtat taatatttca attgtcaata ttaatgtttt
    14821 gcttgttagt attaatattt caattgtcaa tattagtgtc ttgcttgtta gtattaatat
    14881 ttcaattgtc aatattaatg ttttgcttgt tagtatcagt gtttcaattg tcaatattag
    14941 tgttttgctt gttagtatta atatttcaat tgtcaatatt agtgtcttgc ttgttagtat
    15001 tagtatttca attgtcaata ttagtgtttt gcttgttagt attagtattt caattgtcaa
    15061 tattagtgtt ttgcttgtta
//
LOCUS       DAEQCW010000091        15079 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.092, whole genome shotgun sequence.
ACCESSION   DAEQCW010000091 DAEQCW010000000
VERSION     DAEQCW010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15079)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15079)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15079
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.092"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..247
                     /locus_tag="KRO40_002774"
     CDS             <1..247
                     /locus_tag="KRO40_002774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093587.1"
                     /translation="DTMALIYLLMNIQRQSEYKYVCSNFVADMLEKSEIDILNKQAFE
                     VTPNDFYNLSGLTLEYEGLLSEYNSRQHSYVSKIANI"
     gene            644..2344
                     /locus_tag="KRO40_002775"
     CDS             644..2344
                     /locus_tag="KRO40_002775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093588.1"
                     /translation="MKRYLKTYGVALIIVIIYAFIKLPVLRLDFTSLFSVGIIFFVVA
                     GILDMMLDRNERASKMAKYNFSIAIALLVYIVVVPFITSTPVLHAKSYRELLGKVTES
                     KFTDDISPVSVNDIRLVDEDMAMKLGDKKLGEVPAIGSVSKLGKFHIQNVDGELYWVA
                     PLVHRDIIKWITSLSGTSGYVKVSASNPQDVQLVQEIDGKPIKIVYQPEAYLHQDLQR
                     HLYIHGIVNVGMTDFTLEINDEGRPYWVVSLYEHKIGYGGANATGIATVDAETGKINV
                     YDVKNTPKWVDRIQPQSFVTDQIKDWGVYVNGFLNSVISEKGVLVPTEGTSLVYGNDN
                     RSYWYTGITSSGGDESTIGFMLVDSRTKEARLYKQPGATETAAMKSAEGNVQEKNYEA
                     TFPVMYNILGQPTYVSSLKDKAGLVKRVAFVSVEDYNVLGIGEDKNEALRNYKDALES
                     KGNDLKLDNDLKDEVLEGTVTRISPDVRGGNTNYYVTLDSNKDIIFRATSKVSSELPL
                     TQVGDKVKISYSKEESGVIEMSEFDNLNIANFEDKKAKEKTGTDENTDSKDSENQGNV
                     "
     gene            2514..3131
                     /locus_tag="KRO40_002776"
     CDS             2514..3131
                     /locus_tag="KRO40_002776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093589.1"
                     /translation="MTNMEKEILLLISRVRCVTESQFRKIYGDQKRYNKKNFKKTLRK
                     MCSEYTLKKYPCDVDYYNYKDLSYVYYLNGSKLFKGDDLIKALVGSELVVRINTAGCD
                     VKRFYRNVSVDDVKYDLFIEYTDQFGNIKQVLVDVDLNNEIDISKYENLSKKIDKSTI
                     PFFKVPNVLVVTPDNLSELNDLERYDNEYSINFIDLGLNKLFNCI"
     gene            3492..4685
                     /locus_tag="KRO40_002777"
     CDS             3492..4685
                     /locus_tag="KRO40_002777"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBH2093590.1"
                     /translation="MSIIVQKYGGSSVADTEKIKSIAENIIERRKENPQMVIVVSAMG
                     KSTDEYITLAKELSNEPSKRELDALMSTGEMISASLLSIALNALGCKAISYNAYQLNI
                     KTSGLHGKSQIDDINVNRIKNSLDEGNVVIVTGFQGINEDGDVTTLGRGGSDTSAVAL
                     AVKLNGKCEIYTDVDGIYFTDPRKYSKASKLDEIEYEEMLELASLGAQVMHSRSIELA
                     QKYGVEIYVGRTCGTEKGTYIRGGKDMKLEDKVITGLATSDDDSSITIKDFKAENISS
                     LFEDIATIGISVDMISQTAPILDKISVSFTVPKEELGECKKIVSKYTDEEHVVIDNNI
                     TKFSLVGLGMKNTSGVAAKVFKIFNENGIMIKLITTSEIRITCAINSDDKQVAIEKIA
                     EVFNI"
     gene            4703..5995
                     /gene="lysA"
                     /locus_tag="KRO40_002778"
     CDS             4703..5995
                     /gene="lysA"
                     /locus_tag="KRO40_002778"
                     /EC_number="4.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HBH2093591.1"
                     /translation="MKLHGTMTVNNDELYIGGVSCLELSKKYQTPLYVFDEALVRQNC
                     REYVEYFKAREGKNKVAYAGKAFLPLYMCNLINEEQMCLDVVSGGELYTAYKSNFPME
                     KVFFHGNNKTKEEINMGLDLGVGKFVVDNFYELDLLEALCEDKGKTQEIYFRITPGIE
                     AHTHDYIKTGQIDSKFGFALVNGDLFRAIEKLSEYKNIKLVGLHAHIGSQIFDVEPYI
                     DTVDIMMNLVKEIKEKFNIQLTEIDLGGGVGVYYSEGDKPKTIKEFCETIITKAETSC
                     KELGIEVPTLVIEPGRSIVANAGSTLYTVGSIKDIKDVRVYVSVDGGMTDNVRPSLYQ
                     ASYECSIVNKINHEAMNHVTIAGKCCESGDILIGDINIMDIKSGDILITTSTGAYGYS
                     MSSNYNKIPRAAVVSVFDGNDKIICKRQSYEDLLALEI"
     gene            6212..6871
                     /locus_tag="KRO40_002779"
     CDS             6212..6871
                     /locus_tag="KRO40_002779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2093592.1"
                     /translation="MRGRVILLISILSIFLVGCSFNKKDEINLVEQGKTYLEKHNYKK
                     AMESLSSALEEDSTNENARAMYMQAMRMSNMTEFEELKNYEGAIKELKLIEKIKNGSS
                     VIKEEATKKKEELTKLEKEQNEAEEQRKKKAKDTAGEDRYRVESDARKSSYSGSSKNN
                     KSSSKNNDKKSDSNKSDNNNSSSQNQEKPNNSNPTPAPTPQDTTGGSDSGGNSQNSNN
                     Q"
     gene            complement(7026..8111)
                     /locus_tag="KRO40_002780"
     CDS             complement(7026..8111)
                     /locus_tag="KRO40_002780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBH2093593.1"
                     /translation="MIIISKENIKYYLIVVFIGILFFKFINTPSDFISSIEGFLKFFS
                     PFLLAILLALLLNPLVMLFEVKFKAHRLLAIFLSYIFIGFILAFAIRLLIPSIANTLN
                     RLINEMPMYTDYIDSFIEKNMSNIDFLKTLIPHIQHSLDNLLKEASNFVGKIPKNFLI
                     YTLSISSMLFNMTMGFILSIYIIYDKEKIALGFKRFLYSSTARNKADNIIEFFRTTHD
                     IFYDYLLGRILDSLIIGIIAFLGFQFVIRIENALFLASIIFLGNIIPYFGPFIGAIPP
                     IAMTILYSPQKTIWVIAFLFILQQLDGNFIEPKVMGNQVGIGAIWVISAILVGQSLFG
                     FIGVFLSVPIAAVVKTYVDKYIDNRLQ"
     gene            8302..9018
                     /locus_tag="KRO40_002781"
     CDS             8302..9018
                     /locus_tag="KRO40_002781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBH2093594.1"
                     /translation="MRINKYIASCGIASRRKAEEIILGGRIKVNGSVVKELSFNIDEE
                     KDIVEFDNKKVKPSENYIYIVLNKPEGYITTVKDQFNRPSVIDILKDVRERVYPIGRL
                     DYETSGLLILTNDGDLTYKLTHPKHEIDKTYVASVKGIISDDEIRQFETGLKIEDYTT
                     APAKIRVTKENKEKNYSVCEITIHEGRNRQVRKMCKAINHPVLNLRRISVGKIVLKDT
                     KVGEYRYLTEDEIKYLKSIK"
     gene            9076..9654
                     /locus_tag="KRO40_002782"
     CDS             9076..9654
                     /locus_tag="KRO40_002782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH2093595.1"
                     /translation="MAYAKYLTKITDINKFYLENIINEGDIVIDATMGNGYDTRYLAE
                     KVGEKGFVYAFDIQEEAIKSTRKKLEKEGYTDRVKLIFDGHEKMNQYIKEEVSCVLFN
                     LGYLPRAKHSIITKPDTTLKAIKLSLEMLKENGVISIAIYTGHDGGQEEKDCIYNLVN
                     NLNQDEFNVLESKFLNQVNNPPQLILIEKKKA"
     gene            10048..10920
                     /locus_tag="KRO40_002783"
     CDS             10048..10920
                     /locus_tag="KRO40_002783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBH2093596.1"
                     /translation="MEETNEMKDSKHLISNIQSQYTRLSKGQKLIAQYILNNYDKVAF
                     MTACKLGETVGVSESTVVRFANALGYSGYPKLQAALQELIKNKLTTVQRVEMAHDYSD
                     DFAILNKVLKSDIDNIRSTLEEIDERAFKEASNKLLRARKIYILGMRSSFVVAQYLGF
                     YLDIILDNVHIIRMDMGDAFEQIVRINEEDVIVAISFPRYSKKSYQIVNYAKEKGAHV
                     ISLTDSLFAPVASLADNTLLVKSNMASFVDSLVPALSISNALAISVGMKEKEDIKQHF
                     DDLEQIWKRYSVYE"
     repeat_region   11751..13215
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=11751..11779
                     /rpt_unit_seq="gttttatattaactatatggaatgtaaat"
     gene            13326..13610
                     /locus_tag="KRO40_002784"
     CDS             13326..13610
                     /locus_tag="KRO40_002784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093597.1"
                     /translation="MLVYNKSFYPNDIFPRLDFSKIKKQLKLIDNDLSDFGSICIIEK
                     EHYTISVNSIGEINVYYDLEYENKVYRIVYEIEKLFKSQVGRFSISTYRN"
     gene            complement(14381..14596)
                     /locus_tag="KRO40_002785"
     CDS             complement(14381..14596)
                     /locus_tag="KRO40_002785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093598.1"
                     /translation="MAIVVNLDVMMAKRKISLKDLAEKIDITNANLSILKTGKAKAIR
                     FTTLNEICKALDCQPGDILEYVEDEND"
     gene            complement(14607..15074)
                     /locus_tag="KRO40_002786"
     CDS             complement(14607..15074)
                     /locus_tag="KRO40_002786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2975 domain-containing protein"
                     /protein_id="HBH2093599.1"
                     /translation="MITKFFSNILSVFLYFLLSLLGVAGIIFLCMIPMFLYDFSSDKV
                     IALIARILYFSDYFIVILFLIFIINSTKYSPFVLENVKRFKVMGCCLLINTIIECING
                     YNLNTNNIRIFGTDSGGISPLMVISFIFALMCFVIAETFDKAIKIKEDNDLTI"
BASE COUNT         6090 a         1555 c         2462 g         4972 t
ORIGIN      
        1 cgatacaatg gcattaatat atttactaat gaatattcag agacaatctg aatataaata
       61 tgtatgttca aattttgttg ctgacatgtt agaaaaaagt gagatagaca ttttaaataa
      121 acaagcattt gaagtaacgc caaatgattt ttataattta tctggcttaa ccttagagta
      181 tgaaggttta ttatcagaat ataattctag acaacattct tatgtatcaa aaatcgcaaa
      241 catttaaaaa cttgatttag agtttttcat ataaaaaaat attgctagat aattaggctg
      301 aagatagtag tttaacttcg ataggattaa gaatttgtaa atcttagtta gaatactttc
      361 ttcagttttt aaatttctgc taatatttgt atttttataa tatttttgga tatatataat
      421 acagaatagt gcaaaaatcc cactccttta ggtgcgggat ggatagtaca aacagtgtat
      481 aaaaagtatt tatacataca cgtataatgt taaatatagt tgaataagca gaactataaa
      541 tatataaaga tatcttaata tataataaat atgataaata tttatttttt gtaaatatat
      601 ggatataata gtaataataa cattttttag agaggagtat taaatgaaac gatatcttaa
      661 aacatatgga gttgcattaa taattgtaat aatttatgca tttattaaat tacctgtact
      721 aagattagat tttacatctt tattttcagt aggaataatt ttctttgttg tagcaggaat
      781 actagatatg atgttagata gaaatgaaag agcatctaaa atggctaaat ataatttttc
      841 aatagcaata gctttgcttg tgtatattgt agtagttccc tttataactt ctacacctgt
      901 acttcatgca aaatcatata gagaactatt gggaaaagta actgaaagta aatttactga
      961 tgacattagc cctgtcagtg taaatgacat tcgtcttgta gatgaagata tggcaatgaa
     1021 attaggtgac aaaaagcttg gagaagttcc tgcaataggg agtgtatcca aattaggaaa
     1081 atttcatata caaaatgtag atggagagtt gtactgggta gcgcctcttg ttcacagaga
     1141 cataattaaa tggataacat ctctaagtgg tacaagtggt tatgtaaaag tatcagctag
     1201 taatcctcaa gacgtccaat tagttcaaga aatagatgga aagccaataa agatagttta
     1261 ccaaccagaa gcctacttac atcaggattt acaaagacat ttatacatac atggtattgt
     1321 aaatgttggt atgacagatt tcactcttga aataaatgat gaaggaagac cttattgggt
     1381 tgtaagttta tatgaacata aaattggcta tggaggagca aatgcaacag gaatagccac
     1441 tgttgatgca gaaactggaa aaataaatgt ttatgatgtt aaaaacacgc ctaaatgggt
     1501 ggatagaata caaccacaaa gctttgtaac agaccagatt aaagactggg gtgtttatgt
     1561 taatggattt ttaaactctg ttatatcaga aaagggagtt ttagtaccaa cagaaggtac
     1621 atcattagtt tatggcaatg ataacaggtc ttattggtat acaggtataa catcttcagg
     1681 tggagatgaa tctacaattg gatttatgtt agttgattct agaacaaaag aagctagatt
     1741 atataaacaa ccaggagcta ctgaaacggc tgcaatgaaa tcagctgaag gtaatgttca
     1801 agaaaaaaat tatgaagcga cgttccctgt aatgtataat atattgggtc agccaacata
     1861 tgtatcatca ttaaaagata aggctggtct tgttaagaga gttgcatttg tatctgttga
     1921 agattataat gtacttggaa taggtgaaga taagaatgaa gcattaagaa actataagga
     1981 tgcattagaa tctaagggta atgatttaaa acttgataat gatttaaaag atgaggtatt
     2041 agaaggcaca gtgacaagaa taagcccaga tgtgcgaggt ggtaacacta attattatgt
     2101 aactttagat tcaaataaag atataatatt tagggctact tcaaaagtat ctagcgaatt
     2161 gccattgact caggttggtg ataaagtcaa aatatcgtat tcaaaagaag aatctggtgt
     2221 aatagaaatg tcagaatttg ataacctaaa tattgcaaac tttgaagata aaaaagcaaa
     2281 agaaaaaaca ggaactgatg aaaatacaga ttccaaagat tctgaaaatc aaggtaatgt
     2341 ataatttaaa taaaaagatt gataatagta tttaacatag tgatagctaa tttttataga
     2401 atttaattct ataaaaatta gctattttat tttaattctt tgtaaattta atgtcataaa
     2461 attaatataa tattagtaca actttgcaaa taatacttca aggagaatgt actatgacga
     2521 atatggaaaa agagatatta cttttaatta gcagggttag atgtgttaca gagtctcaat
     2581 ttagaaaaat ttatggagac caaaaaagat acaataaaaa aaattttaaa aaaactttga
     2641 gaaaaatgtg tagtgaatat acactaaaaa aatatccttg tgatgtggat tattataatt
     2701 ataaagacct ctcttatgta tactatttaa acggtagtaa actttttaag ggagatgatt
     2761 taataaaggc tctagtagga tcagaattag ttgttagaat caatactgca ggttgtgatg
     2821 taaaaagatt ttaccgaaat gttagtgtag atgatgtgaa atacgattta tttattgaat
     2881 atacagacca atttggtaat ataaagcaag ttttagttga tgttgactta aataatgaaa
     2941 tagacatttc taaatacgaa aatctttcta aaaaaataga taaatctaca attccatttt
     3001 ttaaagtacc aaacgttttg gtagttacac cagataatct atccgaatta aatgatttag
     3061 agagatatga taatgagtat agcataaatt ttatagattt aggattaaat aaactattta
     3121 attgtatata agctaacttt agaaaagaaa actatcgatt tgccacattt tgtaaaataa
     3181 ttgttgcaat attatataga atatgataaa actatattaa taaattaatt aaaaataatg
     3241 agcctagggt agaggtagct gtattcaata gtattcaata ggagctggta agcgttgata
     3301 attgatgaaa gggtatatag ccgaagaaat tttgttgacg gacaaatttt ctggacttat
     3361 gcagaatatg cataaggctg tcacttttaa agtggtgagc tacaaggtta cttggtctat
     3421 gaaatttaca cgtccaaagt atacctttgg gcgtttttat ttatcaaaat ttagcttgag
     3481 ggggagaaag catgagtata attgttcaaa aatatggtgg aagttcagta gcagatactg
     3541 aaaaaataaa atcaatagca gaaaatataa tagaacgaag aaaagaaaat ccacaaatgg
     3601 taatagttgt gtctgccatg ggaaaatcca ctgatgaata tataacttta gcaaaggaat
     3661 tgagtaatga acctagtaag agggaattag atgctttaat gtctactggt gaaatgattt
     3721 cagcatcttt attatcaata gcattaaatg cacttggatg taaagctata agttataatg
     3781 cttaccagtt aaatataaaa acgagtggtc ttcatggaaa gtctcaaatt gatgatataa
     3841 acgtaaacag aattaaaaat agtttagatg aaggaaatgt cgtgatagta actggatttc
     3901 agggaatcaa cgaagatggt gatgtaacca ctcttggaag aggtggttca gatacatctg
     3961 ctgtagctct tgcggttaaa ttaaatggaa aatgtgagat atatacagat gttgatggaa
     4021 tttattttac agacccaaga aaatattcaa aggctagtaa acttgatgag attgaatatg
     4081 aagaaatgct tgagttagcg agtttaggag cacaagtaat gcattcaaga agtatagagc
     4141 ttgcacaaaa atatggtgtt gaaatctatg tcggacgtac atgtggtaca gaaaaaggaa
     4201 catatataag agggggaaaa gacatgaaat tagaggataa agtaataaca ggattagcta
     4261 ctagtgatga tgacagttct ataacaataa aagattttaa agctgaaaat atatctagct
     4321 tatttgaaga tatagcaact ataggtataa gtgtagatat gataagccaa actgcaccta
     4381 ttttagataa gataagtgta tcatttacag ttccaaaaga agagttggga gaatgtaaaa
     4441 agatagtatc taaatataca gatgaagaac atgtagtgat tgataataat atcactaaat
     4501 tttctttagt aggtcttggt atgaaaaata cttctggagt tgctgctaaa gtatttaaga
     4561 tattcaatga aaatggtata atgataaaac ttataactac atcagagatt cgtataactt
     4621 gtgctataaa ttctgatgat aagcaagtag ctatagaaaa aatagcagaa gtatttaata
     4681 tataaaattt ggggaggcta ttatgaaact tcatggaact atgactgtaa ataatgatga
     4741 attatatatt ggaggagtga gttgtttaga acttagtaaa aaatatcaaa ctccacttta
     4801 tgtatttgat gaagctttag ttagacaaaa ttgtagagaa tatgtagaat attttaaggc
     4861 tagagaggga aaaaataagg ttgcttatgc agggaaagct tttttacctc tttacatgtg
     4921 taatcttata aatgaagaac aaatgtgttt agatgtagtt tcaggaggcg agttatatac
     4981 agcttataaa tcaaattttc ctatggaaaa agttttcttt catggaaaca ataagactaa
     5041 agaagaaata aacatgggat tagatttagg tgtaggtaaa tttgtggtgg ataattttta
     5101 tgaattagat ttgcttgaag cattatgtga agataaaggt aaaactcaag agatatactt
     5161 tagaataact cctggtatag aagctcatac acatgattat ataaaaactg gacagataga
     5221 ttctaaattt ggatttgctt tagtaaatgg agatttattt agagcaatag aaaaattaag
     5281 tgaatataaa aatattaaac ttgtgggtct tcacgctcat ataggttcac aaatatttga
     5341 tgtagaacca tacatagata cagtggatat aatgatgaac ttggtaaaag aaataaaaga
     5401 aaaattcaac atacaactaa cagaaattga cctaggtgga ggagttggcg tttattatag
     5461 cgaaggagat aaacctaaaa ctataaaaga gttttgtgaa actataatca ctaaagcaga
     5521 aacttcatgt aaagagcttg gaatagaagt acccacattg gtaatagaac caggaagatc
     5581 aatagttgca aatgcaggaa gtacattgta tacagtaggt tctataaaag atataaaaga
     5641 tgttagggtt tatgtaagtg tagatggagg tatgacagat aatgtaagac cttcgttgta
     5701 ccaagctagt tatgagtgta gtattgtgaa taaaattaat catgaggcta tgaatcatgt
     5761 aacaatagct ggaaaatgtt gtgagagtgg agatatatta attggagata taaacataat
     5821 ggatattaaa agtggagata tacttataac aacatcaact ggtgcatatg gatattcaat
     5881 gtcttcaaat tataataaaa taccaagagc agcagtagta tcagtatttg atggaaatga
     5941 taagataatt tgtaagagac aaagctatga ggacttatta gctttagaga tataaaatgg
     6001 agaagtatat aataaaaatt aaatattaaa gtttattatg agcagatttg ctaggatatg
     6061 tatctctaaa ttaatttttg gtttattgta tcgttcgtag catatctgct tattttttgt
     6121 tttactaaca aatttcttgt aataaatata aaatatttta aaaactttat aattatgata
     6181 aaatttaaag tatatgacaa ggagggattt aatgagagga agagtaattt tattaatatc
     6241 gatattatct atatttcttg taggatgttc atttaataaa aaagatgaaa taaatttagt
     6301 agagcaagga aaaacatatt tagaaaaaca taactataaa aaagctatgg aatcattatc
     6361 ctctgcactg gaagaagata gtactaatga gaatgcaaga gctatgtata tgcaagctat
     6421 gagaatgtca aatatgacgg agtttgaaga attaaaaaat tatgagggtg caatcaagga
     6481 acttaaactt atagagaaaa tcaaaaatgg ttcctctgtt attaaagaag aggcaactaa
     6541 aaagaaagaa gagttaacta aattagaaaa agaacaaaac gaagcagagg aacaaagaaa
     6601 gaaaaaggca aaagatacgg ctggagaaga taggtataga gttgaatcag atgcaaggaa
     6661 atcttcttat agtggaagta gtaaaaataa taaatctagt tctaaaaata atgataaaaa
     6721 atcagatagt aataagtctg acaataataa cagttcttct caaaatcaag aaaagccaaa
     6781 taatagtaat ccaacaccag caccaactcc acaagatact actggtggtt cagatagtgg
     6841 tggaaattct caaaactcaa ataatcaata agtataaaat atatgcataa atttaatgaa
     6901 caaattatat attataaaaa atatctctta gcaatttttt cttactaaga gatatttttt
     6961 gagaaataat ttaataaata acagttaaat tttaaactaa aaattaaagt cacagtagag
     7021 ataagctatt gtaaacgatt atctatatat ttatcaacat aagtttttac aacagcagct
     7081 attggtactg aaagaaaaac tcctatgaaa ccaaatagag attgtcccac caaaatagca
     7141 gatattaccc atatagctcc tataccaact tgattaccca taacttttgg ttctataaaa
     7201 tttccatcta attgttgcaa tataaataga aatgcaatga cccatatagt tttttgtgga
     7261 ctatataata tagtcatggc tattggaggg attgcaccaa taaaaggacc aaaataggga
     7321 attatattac ctaagaatat tattgaagct aaaaataaag cattttctat tctgataaca
     7381 aattgaaatc ctaaaaatgc aattatacca ataataagag agtctaatat tctaccaagt
     7441 aaataatcat agaaaatatc atgagtagtc ctaaaaaatt ctataatatt atctgccttg
     7501 tttctagcag tagaagaata tagaaatctc ttaaatccca atgcaatttt ttctttatca
     7561 tatataatgt atatagatag tataaatccc attgtcatat taaatagcat agaagatata
     7621 ctaagtgtat agattaagaa atttttagga attttaccaa caaaattact tgcttctttt
     7681 aataaattat ctaaactatg ttgtatatga ggaattaaag tttttagaaa atctatgttt
     7741 gacatatttt tttctataaa actatctata taatcagtat acataggcat ttcatttatc
     7801 aatctattta atgtattagc tattgatgga attaataacc taatggcaaa ggctaaaata
     7861 aaacctataa atatataaga taaaaaaatg gctaaaagtc tatgtgcttt gaattttacc
     7921 tcaaaaagca tcacaagtgg atttaaaagt aaagcaagta aaatagctaa taaaaatggg
     7981 ctaaaaaact ttaagaatcc ttcaatacta gatataaagt ctgatggagt attaataaat
     8041 ttaaaaaata aaattccaat aaacacgact attaaataat attttatatt ttcctttgaa
     8101 ataataatca cttccttaaa atagtgttta gtcagctatt acatattaat agtatgtgaa
     8161 aagaaattac aattatttag gaaaattaaa taattttttt gcttgttttt aattaaggtc
     8221 tagtatagta taataatgta gcaaaattaa cattgataaa aatattaaac acacataatt
     8281 taagataagg aaggattaag tatgagaatt aataagtata tagcttcttg tggaatagca
     8341 tcaagaagaa aagcagaaga aataattctt ggaggaagaa taaaggtaaa tggaagtgta
     8401 gtaaaagagt tatcttttaa tattgatgaa gaaaaagaca tagtagaatt tgataataaa
     8461 aaagtaaaac caagtgaaaa ttatatatat atagtattaa ataaaccaga gggatatata
     8521 actacagtaa aagaccaatt caatagaccc agtgtaatag acatacttaa agatgtaagg
     8581 gaaagagtat atccaatagg gagattagat tatgaaacta gtggattatt aatacttact
     8641 aatgatggcg atttaacata taagcttacc catccaaaac atgaaattga taaaacgtat
     8701 gtggcaagtg tgaagggaat tataagtgat gatgagataa gacaattcga aacaggacta
     8761 aaaatagaag attacacaac ggcacctgct aaaataaggg taactaaaga aaataaagaa
     8821 aaaaattatt cagtgtgtga aataactata catgagggta gaaatagaca agtaagaaaa
     8881 atgtgcaaag ctataaatca tccagtttta aatttaagaa ggatttctgt ggggaaaata
     8941 gtattaaaag acaccaaagt tggagaatat agatacctaa cagaagatga aataaaatat
     9001 ttaaaatcaa taaaataaga taaaaataaa ttgagaaaaa atgaaataaa gttaatagta
     9061 gggagaaata gtattatggc atatgcaaag tatttaacta aaattacaga tataaataaa
     9121 ttttatttag aaaatattat aaatgaaggt gacatagtaa ttgatgctac tatgggaaat
     9181 gggtatgata caaggtatct agctgagaag gttggagaaa agggctttgt atatgctttt
     9241 gatatacaag aagaagcaat aaagtctaca agaaagaaac tagagaaaga aggatataca
     9301 gatagagtaa aattgatatt tgatgggcat gaaaaaatga atcaatatat aaaagaagaa
     9361 gtttcatgtg ttttatttaa tttgggttat cttccaagag cgaaacattc aattataacc
     9421 aaaccagata caactttaaa ggctataaag ttaagtttag aaatgttaaa agaaaatgga
     9481 gtaataagca ttgccatata tacagggcat gatggaggtc aagaagaaaa agattgcata
     9541 tataaccttg tcaataattt aaatcaagat gaatttaatg ttttagaatc taagttttta
     9601 aatcaagtca ataacccacc acaattgatt ttaattgaaa agaaaaaagc ataataaata
     9661 ctaaaaaact tgacaagatt gtattaagag ttaatatata tagtgtgacc tattaaaaat
     9721 actttaaata ataagtatac aacagcttat tctcaaaaca aaatatacat ctaaatatgc
     9781 aaaataagat agataacttt taaatgagta aaaattgaaa aatttaaaag aaatattgga
     9841 taaatattaa aaaatgcaag gaaagatggt ataataaatt taatcgaaaa tactatgtga
     9901 aatataaggt acagaaaagt tagaatttta tgagtttaag aagctatgat aaaaactaag
     9961 atgaaattga gataaaaaat aaaattttta gagaaaaaga cagtgttaat aaaacaaaat
    10021 agtttatata actaaaagga gaaaaaaatg gaagaaacaa atgaaatgaa ggacagtaaa
    10081 catttgatat caaatataca atctcaatat acgagattga gtaagggtca aaaacttata
    10141 gcacaataca ttttaaataa ttatgataaa gttgcattta tgactgcatg taaattgggt
    10201 gaaactgtag gagtaagtga gtctacagtt gtaagatttg caaatgcatt aggttatagt
    10261 ggatatccta aattacaagc tgcacttcaa gaactcataa aaaataaact aactacagta
    10321 caaagagttg aaatggcaca tgattattcc gatgattttg caatactaaa caaagtttta
    10381 aaaagtgata tagataatat aaggtctaca ctagaagaaa ttgacgagag agcgtttaaa
    10441 gaagcttcta acaaactttt aagagcgaga aaaatatata tacttggaat gaggagttct
    10501 tttgtagtag ctcaatattt aggtttttac ttagatataa tacttgacaa tgttcatata
    10561 attagaatgg atatgggaga tgcttttgag cagattgtaa gaataaatga agaagatgta
    10621 atagttgcta ttagtttccc tcgttattct aagaaatctt atcaaattgt caattatgct
    10681 aaggaaaaag gagcccatgt aatatcatta acagatagct tatttgcgcc agtagcatca
    10741 cttgcagata acactcttct agttaagagt aatatggctt catttgtaga ttctctagtt
    10801 ccagctctta gtatttcaaa tgcccttgct atatctgttg ggatgaagga aaaagaagat
    10861 attaaacagc attttgatga tttagagcaa atttggaaaa gatattctgt gtatgagtaa
    10921 agtttgtata ttaataagta ttattaatta ttaaaatgtt caaatatagt gatgtttgga
    10981 taaaatatat aaaatagctg actggcattt aactgacagt cagttttttt atttaaacaa
    11041 tattttgctt aaattttaag gaatatcttt gtctatttct tctaaatgag agtatttatt
    11101 catagttatt ttcatttatt atatttcttg ttgattatat atttttttat agaaaagaaa
    11161 atagttatgg ttttgtatct gttatttttg cacttattca atttattttt gtgaaacctg
    11221 gaaagataaa actttaatag cagataataa ccttgagatt gtaaagtaac aaagtgaaaa
    11281 tgtataaaga ggaaaagaaa tggaaggaag aaaagtatat agataaagag atataacacg
    11341 tattttgatt taactgtata agatgaaaaa tttgatgatt ttgaataatt taaaaaattg
    11401 ttaatgaaaa taaaagactt attgagctaa ggtgcgatta cataggaagg atgcaataaa
    11461 aagaaaaagg aatcattgga atagagaata taataaatac ttataagaat gtagatgctt
    11521 ttagtttgta aaattatccc atttttattt tatagtatga gttttatgat ataataaaaa
    11581 tataaaagtt ttgcagtgag cgatttttgt gataaagtag ggtttaatag ttgaaatata
    11641 aagcgttgag agtgtatgat aactgttatc aattgcacta ttgctcgctc actgcaagtt
    11701 taggagaatt gtatatgtat aagtattgga aatacttaat ttattttggg gttttatatt
    11761 aactatatgg aatgtaaatt ttctttttga agttgttgac gctctttttc atcagcgttt
    11821 tatattaact atatggaatg taaatacatc aagactatct atattattaa gagtaacttt
    11881 agttttatat taactatatg gaatgtaaat ctaacttgtt tccctctaaa gcgtgtttag
    11941 tagggtttta tattaactat atggaatgta aatctctttt gcgcagagtg gttttttact
    12001 tgtctaaata gttttatatt aactatatgg aatgtaaatt aaagaccttt tttcatgttg
    12061 cactctaaaa atctaagttt tatattaact atatggaatg taaatgataa ggaatctgaa
    12121 tattaataac accagaatct ccgttttata ttaactatat ggaatgtaaa tctactagca
    12181 ggaacatcaa aaggaggttt aaaatccgtt ttatattaac tatatggaat gtaaatacca
    12241 aaaggaatgt ttatttttga ctttgcttat caattgtttt atattaacta tatggaatgt
    12301 aaatatactt ggtcaataca tttcaaaagt tgcaacagaa cgttttatat taactatatg
    12361 gaatgtaaat aacttatcag catctttttt ataagttcca accacgtttt atattaacta
    12421 tatggaatgt aaatttatca ttttttccgc ttctgcttgt aatttagact cgttttatat
    12481 taactatatg gaatgtaaat ttccctaatg ctccattttc attataatct ggtgtagttt
    12541 tatattaact atatggaatg taaatgtagg tgtcggagag ctaggaaact atagcataat
    12601 ggttttatat taactatatg gaatgtaaat cgttcttgga atgctaaaac tcgtccttct
    12661 tggaataagt tttatattaa ctatatggaa tgtaaatctc ccaggagtac cgctataaaa
    12721 ataaatcata caatgtttta tattaactat atggaatgta aataattttt gaaatgcact
    12781 gaatactcat ttattacatc gttttatatt aactatatgg aatgtaaata ggaacaaatt
    12841 gctaaaaaat taggggttgg ttattcgttt tatattaact atatggaatg taaatctgag
    12901 aaagttttat tcttttttaa tgttacaaat cgttttatat taactatatg gaatgtaaat
    12961 aaattattcc ctaaaaaaag tttatttctt tctactagtt ttatattaac tatatggaat
    13021 gtaaatatta cagtttcttt attttttatt attgtacttg gcgttttata ttaactatat
    13081 ggaatgtaaa tacaataccc ccctattgca atgcttcatt aactattagt tttatattaa
    13141 ctatatgtaa tataaatgtt ttttcttatt aaataaagat tgagtcactt tatatttaat
    13201 aatacatatt ctaaattgat tttgttttta tataagagaa tttgaataat atggaaaaag
    13261 atgattaata aattattaat tagggtataa aatgatataa atagaataaa taaggggtgg
    13321 atgaaatgct tgtatataat aaaagttttt atcctaatga catatttcca agattagatt
    13381 tttcaaaaat aaaaaaacag ttaaaattga tagataatga cctgtcagat tttggaagca
    13441 tatgtataat agaaaaagaa cattatacaa taagtgtaaa cagtataggt gaaataaatg
    13501 tgtattatga tttagagtac gaaaataagg tgtatagaat agtttatgag attgaaaagt
    13561 tatttaaatc tcaagttgga aggtttagta tatctacata cagaaattga taattaaaaa
    13621 agtagaaatt aaaaaactta atactaaaga tatagataaa tatatgaggt aacagctaga
    13681 gagagttgtt acccttttta aatactaagt atatattatt cttattaatt ttttgtaaat
    13741 tcactaaaag acctttttat agaatattat tttctttttt tattaaatag gtaaatcagt
    13801 aaaaatgcaa ttccagttcc aattattatt ccaatgatat tttctataat taattttttt
    13861 aatataaaag taaataataa aaatgctata cataaaccta aaatatatcc tttaaaatag
    13921 gttgaaagtt ttcttttcat ataatcacca acttgtatca gatttagttt acttaattag
    13981 agtataacag tgttgtaact tcaaagagta tctaaaagat tacaaatgtt agataaaatc
    14041 atcaataatg taatttataa cacgtagcta taaactatgc aataatataa atggaggtat
    14101 aagtaaatga aaaagttcca tgttttgcta acagtttaaa caaatattag gtagaaaaga
    14161 atgtatatag gaatctgtgg taaaattatc aatttaaaag tatgatttag tgtgatacag
    14221 ttcttatagg taatggataa caaatagata aaggaacagt ttctttctta gaacatattt
    14281 tgttatgact ttaaacaaag ttaatattaa tgtcaataat atagtaaaag aataaaaatc
    14341 atatagtata ataaaaaaga gtgtttctaa acactctttt ttaatcattt tcatcttcta
    14401 catattcaag tatatcacct ggctgacagt ctaaagcttt gcaaatttcg tttagagtgg
    14461 taaatctaat agcttttgct tttccagttt ttaaaattga taaatttgca tttgtaatat
    14521 ctattttttc tgccaaatct ttaagtgata ttttcctttt tgccatcatt acatctaggt
    14581 taactactat tgccataaca tcacctctat attgttaaat cattatcttc ttttattttt
    14641 atagctttat caaatgtttc tgcaattaca aagcacatta gtgcaaatat aaaagagata
    14701 accataagtg gtgagatacc gccactatca gttccaaaaa ttcttatatt attagtattt
    14761 aaattataac catttataca ttcaattata gtgtttatca ataaacaaca tcccattacc
    14821 ttaaaccttt ttacattttc aagtacgaat ggggaatact tagtactatt aattataaat
    14881 atcaagaata agatgactat aaagtagtca gaaaaatata gtattcttgc aattaaagcg
    14941 attactttgt cagaactaaa atcatataaa aacataggta tcatacataa gaatattata
    15001 ccagcaactc ctaaaagtga taatagaaaa tatagaaata ctgataatat attactaaaa
    15061 aattttgtaa tcataaaat
//
LOCUS       DAEQCW010000092        14772 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.093, whole genome shotgun sequence.
ACCESSION   DAEQCW010000092 DAEQCW010000000
VERSION     DAEQCW010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14772)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14772)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14772
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.093"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            162..557
                     /locus_tag="KRO40_002787"
     CDS             162..557
                     /locus_tag="KRO40_002787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093600.1"
                     /translation="MNILKMKKTGIFLGGVLFGTVGVKILSSDCVKKTCTRATAGALK
                     VKDSVLETTTKIQENVEDILAEAKEINEQEDLSTSKVNVVQDTLKCEQEVLKTETIKT
                     VEDTNSNSIKCEEIKDNVIEEKNSTCTTE"
     gene            600..2699
                     /locus_tag="KRO40_002788"
     CDS             600..2699
                     /locus_tag="KRO40_002788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HBH2093601.1"
                     /translation="MNFYIKHEIRGRIRFDLQLGKLNNKQSDTLLYYLTSINGITKAK
                     VYDRTGDAVIYYTGEREYIIREITKFSFNNSKIENLVPEHTSRELNNYYRDKLANKLL
                     VKSISKIFFPKSLRFFLIGLHSIKYFKKGLSSLLNKKIEVSVLDATAIGISIFRKDIN
                     TAGSVMFLLGIGELLEEWTRKKSIDDLAQSMSLNIEKVWLRKGDTEILIPISEIKEGD
                     LVSVTMGNMIPLDGVIVSGETMVNQASLTGESLAVNKKEGSYIYAGTVIEQGNIVMCV
                     KEKAGTTRFQKIVTMIEESEKLKSSVESKFEHLADTLVPYSFLGSILTYAITRNPIKS
                     LSILMVDFSCALKLSIPISVLSAMRECNNNNITVKGGKFLEGVACADTIVFDKTGTLT
                     KAQPTVSDIITFQNYNKEDMLRLAACLEEHFPHSIANAVVYEAEKQGLSHKEMHTEVE
                     YIIAHGISTKVDDKKVVIGSKHFVFEDEKCTIPDGEEDKYNNLSDEYSHLFMAISGKL
                     SAVICINDPLRKEAKYVISNLRECGIKKIVMMTGDSEKTAKSIASKVGVDEYYSEVLP
                     EDKANFVKSEKLKGRKVIMIGDGINDSPAISESDVGIAMSEGAEIAREISDITISADN
                     LNNLIVLKQISNKLMKRVDLSSKFIIGFNLGLILLGVGGFVRPSTSAFLHNASTVGIS
                     LNSMTNLLENTNTYNYH"
     gene            complement(2924..8134)
                     /locus_tag="KRO40_002789"
     CDS             complement(2924..8134)
                     /locus_tag="KRO40_002789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosome-binding GTPase"
                     /protein_id="HBH2093602.1"
                     /translation="MANKLYSEIVNLLEEGRDELRKYDLKEKSILLFLGASGVGKSTC
                     INYLKGCVMEEKTDEETGQIYITAKDSAVEIGNGVYSKTLCPEVVDIANRDFSLCDCP
                     GFFDNRGAEYMIAGAMLVRETISTSSKVKGMVVILDYQSLLDSRHTLLIETGKNLKDM
                     LGDYAKYKENFFFLINKIPKALIGNVTEEKIRNILKKAKEDLDSQEKDYDGYKELVYL
                     LNVALSDGVSIKLCNPLDKQPEKLLNEMKNLPETFEKTDLGLMLTASCKIEIQKAVDV
                     TYKDLEKLLVPYIESVKKGMEDSISILSSINSLKDKKIQLDKMYTDLCSRTNNMKELM
                     EFVQELSYGDGVQKVNILEETRLLLELNSYCSETHIVGLSELLKSLLKNTLEDTLKDI
                     KYWIAEEEYREEEAKKLEDAEYRIEKIQSCTYIKSYEKENVLSIYIPIPKVNLSDLTK
                     IISGYQLNILSSIYMYGDCELKIDCNMEKEVFSGKNIVLLTEKLHIPEGTYSINVSGK
                     DAEKLVGESSIYDGMNGRNGNNAGTSGDIILSFKEIEKRGELKLYVDGGRGGNGQDGK
                     KGDTGITGEAGANAKIGSKKESKEFANVKGTKYYVVKAEKGKQGGTGGTGGNGGNAGL
                     GSKSGQVYLLGKAPLLKSAISKKDGNHGLAGKGGSGGAGGAGGLGGIRGIYEETIRYI
                     GTSPPMDNSDRNYYYFDRYVFNHALNQKQAADDGEKLNTLYEEHKDWTISKREDSGSA
                     GAEGKAGHSGDALKEKELLKQEYSLSIDTFFYEFFERFGFSGIKGYRNLRLLCAVGIL
                     EADILELSHIYEIFHAVEKIEMQLNREILQKYYSFEKKNKAVLSLDDMNTKKEFYKEA
                     KEIYEYLINKLMQSDRIESFVGKNQNFSEWSMILFALEQKTAFYVQMIEESEIGGNRV
                     TDIRSLTDYLDKTLRELEQGKKDELKEGYFNTYKESILTQIESGNQQIEVLKNELENK
                     MLSVNAKMNLLIQEIIKMKEDEQEDIEELKKKQAKLEEQMKTQLILSGIQSALSLLTA
                     FSGVGQACLGAFDSAKSLKENLSSKEEEYKWTNRMVNFSDFKLDSDGMRFVLGEQLSE
                     DRKNALDKMTYNLAGVDEERRTKFDQIKEIIVKSIDDDNYADKADDIQRAKEGLSESE
                     YKEIYTKIQKKEIGMLEANYNNKQQKDKLAALEKSKQAIERQQKTSKIKNALSIGSSA
                     CSLINTAISGVNNCLNVKSSFESKIEVVKEAIKDKENNIKKLDELNTQMVEFKDKTLK
                     ESVIPFVEKFDSTVKNQDIFENEISKLKMKEVLTELSTKFGSLKMENSEEISIIFKKV
                     QDMMETQIIITDKIDKKKDNLAMGELIYQMSDSGNQMNEYQKKLIHQIELNQVRYLCQ
                     VEAAAFQLWTFPFGSNIVNILNRCHVGITEDENEVINQAKEQNRQIREFLDQDAYQWQ
                     KTDNHILKVALTGSLDGKSRVGFENTYSLYDCNEEEVKKLLTGDEISFEVPLNKNFDA
                     IKYVTMYANIPNLRRNILEDSLKVKVHIHLYDSGYFSLYDDKKDVYYQYVFPQNYINI
                     THGLDVKYNDSDSINSIWSSVEDKGIEKFKNAGLNSGRSPYSMAKISLKAHFNRKLSY
                     DSLTNEQKKKLESYFDKPSKYAWSDSIDILRSLGYIDLKGILSKSWYEIKKDIDSDGE
                     IMKHFSILQVDLLERIIYEQTSILKENIPNLTIELVGCGIYVESEFNYLKQNDLKCYE
                     ERLVENTIIG"
     gene            complement(8149..10644)
                     /locus_tag="KRO40_002790"
     CDS             complement(8149..10644)
                     /locus_tag="KRO40_002790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2093603.1"
                     /translation="MPENNNQLLEEITLLLNEGKVAINKAENQNLILILGGTGCGKST
                     AINYLAGCVMMEVEDEDTGISYIDCLDPVAEIGSGAVSQTLYPNIVNMRKPIEGMDAK
                     LCDTAGFSDNRGVAHDISAAVSLGEVFKNSASICAVIVLIPEADILDSRLTKVLDLFQ
                     QLNMCLHKENFKGSITFFISKSFLGRTEKQIYNVIKRKYEQLCENLDSNIEEKAWLFE
                     ELLKDNGKNIHLCKPLASDERDGLLKQVLELDEVKDKTSAFQYPISADARLVLDTLIK
                     EIQNNIVSSLEDYVKAYTEDFISIIGSITMIQEIAKYDEVVKVFKNWLESTTSLTIDR
                     FINVLAKQSGLFLQDSCMKLQNKIKGNLDIIDALSKYTEHGTGEILLPSVHMEFIIEK
                     ASKKIMEQNFIIIRKNLEKVLVSYEVQKQVFTLPNREKLMEVANKKDYVYSVSDFNSI
                     LTNVTVTQNEELEDSITRLSAYGEEGNEIIREFIGKYILNPFIVKTININDKKGIEIR
                     ALIPNLVISSVLEYFKNRKVDDNVSTFMFFAKDTIYMDDNLGMDFASEKNIILACNNL
                     DVGSNVKINVSGKSGELVDSSMYGKNGEDGRDSGNIYLYIKEEIRNYRLTLIANGGNG
                     SKGIDGKNGETGASGSNGADAGYTSYFHGQMFKGYFAKGTSGKKGEKGGAGGNAGRGG
                     NAGKKGNIYFISDSEEQKNRIINHCDITVKDGEAGPNGRPGSGGYGGSGGYHGYNTLS
                     FSPSGIDKTVYYTGYFTSWDYKLDSIIKYHIEFSGGSWNEGKTGPAREYAEYGDRGDN
                     GGFNAPNTKLSTAVSKVEENLIKEKYQGYCSEI"
     gene            complement(11281..11568)
                     /locus_tag="KRO40_002791"
     CDS             complement(11281..11568)
                     /locus_tag="KRO40_002791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093604.1"
                     /translation="MRLNVTKQNTIEVENSRKEDVYFVIVDNVFFERQGDVFNSITNN
                     NLNNYDVKILPTDNVFLELKITSTKDLEPVFIVVEDRQYNHGSIMFKPVLV"
     gene            complement(11588..11863)
                     /locus_tag="KRO40_002792"
     CDS             complement(11588..11863)
                     /locus_tag="KRO40_002792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093605.1"
                     /translation="MSLFVGGWSKFRAVEEEDLKVFNEAVGMLEGVGYEPLIVSTQVV
                     AGTNFKFICNATSVTNPPQNYLAEIVVFKPLPCDEHNATITSINIIK"
     gene            complement(12496..12675)
                     /locus_tag="KRO40_002793"
     CDS             complement(12496..12675)
                     /locus_tag="KRO40_002793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093606.1"
                     /translation="MGKDRFEKVYSQGKINATEIWVDKETGVNYVFHYYGNAAGFTPL
                     LDREGKPVISPIVSK"
     gene            complement(12960..14426)
                     /locus_tag="KRO40_002794"
     CDS             complement(12960..14426)
                     /locus_tag="KRO40_002794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093607.1"
                     /translation="MKRKPQYLIIFEHIIQQIYTGKITIGDRLDSIKSMSEEYMVSKN
                     TIKTVIKMLSEKGFIETKAGSRPVLIQSTSKQSIESDLLYEKILQISEIYKIFSLIFP
                     SIAMYNIKRFTSKDFEELNEIIDCMEKNSSNYLVFKEQRLKYINKLISKTNNFLIHHF
                     CEIIQHDVIISQLAYNFDNLDNCCIDFFRNKYIEQVRKTYLYGLDGNLIEFKKLLTYM
                     YKACRESILKIVENRAPQSIDTSSFNSVTLEKCYLYDLIVSDVICQIFEGNIKIGDCL
                     PSITSIINRYNVSLPTVRSAYNELNELGIAKTINGKGTYVTLFSEYDDDYINTEEGAK
                     RLSLLLDAMEFVTITLEDVVLLLGNKMDLIAVDKIETHLRYLQNNCEECKVYPDFVLL
                     CKIVDYTQIYVLQETFLHLKQYMIFGIYLERFFHEEYNEILKTRFDVCFEILRYLKKG
                     DVERFAESFSNIFKESLQYLKKVISSLNVDMRVKLDIL"
BASE COUNT         4821 a         2619 c         1673 g         5659 t
ORIGIN      
        1 tataaactac gcatgtaaaa ttcatgtaaa tttactaata taaatcaaat aaaattacta
       61 aactctctaa actaattttg taaaacatac tctattttta acatttgtta ccttatacat
      121 aagtacaaac aaaatctaac taaatgaaag gataatgtaa aatgaatatt ttaaaaatga
      181 aaaaaacagg gatattttta ggaggagtac tttttggtac tgtaggtgtt aagatacttt
      241 caagtgattg tgttaaaaaa acttgcactc gtgcaacagc aggagcattg aaagttaaag
      301 attctgttct tgaaacaact acgaaaattc aagaaaatgt agaagatatt ttagctgaag
      361 caaaagaaat caacgagcaa gaagacttat ctacatctaa ggtaaacgtt gtacaagata
      421 ctcttaaatg cgaacaagaa gttcttaaaa ctgaaactat aaaaactgta gaagatacta
      481 attctaatag cattaaatgt gaagaaatca aagataacgt aattgaagaa aaaaatagta
      541 cttgtacaac agaataaatt taatgattat tatgattaat aatatcagga ggaagtaaat
      601 tgaattttta tataaaacac gaaataagag gtcgtatacg ctttgactta caacttggca
      661 aattaaacaa caagcagtcc gatactctct tatattattt aacttctata aatggtatta
      721 ccaaagcaaa agtttacgat agaactggtg atgcagtcat ttattacact ggtgaaagag
      781 aatacataat aagagaaatc actaaattca gttttaacaa tagcaaaata gaaaacctag
      841 ttcctgaaca taccagcagg gaattaaaca attattatag agacaaatta gcaaataaac
      901 tgctagtcaa aagtatctcc aaaatatttt ttccaaagtc cttaagattt tttttaattg
      961 gacttcattc tataaaatat tttaaaaaag gtctctcttc cctgctaaat aaaaaaatag
     1021 aagtttctgt tttagatgcc actgctatag gtatttctat ttttagaaaa gatatcaata
     1081 cggctggttc agttatgttt cttcttggta tcggtgaact attagaagaa tggactagaa
     1141 aaaaatctat agacgacttg gctcaaagta tgtcactaaa cattgaaaaa gtatggttaa
     1201 gaaaaggtga cactgaaatc ttaattccaa tttcagagat aaaggaagga gatttagtaa
     1261 gtgtaactat gggaaatatg attccattgg atggagttat agtatcagga gaaacaatgg
     1321 tcaatcaggc atcacttaca ggtgaatccc ttgcagttaa caaaaaagaa ggctcttaca
     1381 tatatgctgg aactgtaata gagcaaggca atattgttat gtgcgtcaag gaaaaagctg
     1441 gtactactag attccagaaa atagtaacta tgattgagga atctgaaaaa ctaaaatctt
     1501 ctgtagagag taaatttgaa catctagcag atacattagt tccatacagc tttttaggaa
     1561 gtatattaac ctatgcaatt actagaaacc ctataaaatc actctctata ttaatggtag
     1621 atttctcttg tgcattaaaa ctctctatcc ctatttcagt actatcagcc atgagagaat
     1681 gtaacaataa caacattact gtaaaaggtg gaaaatttct tgaaggtgtt gcatgtgcag
     1741 atactattgt atttgataag acaggcacat taacaaaagc tcaaccaact gtttcagata
     1801 taattacatt ccaaaattat aataaggagg atatgttaag acttgcagct tgcttagaag
     1861 aacacttccc acactccata gcaaatgcag tagtttatga agctgaaaaa caagggctta
     1921 gtcacaaaga aatgcataca gaagtagaat atattattgc tcatggcatt tcaacaaaag
     1981 ttgatgataa aaaggttgta ataggtagca aacattttgt atttgaagat gagaagtgta
     2041 ctatcccaga cggtgaggag gataagtaca ataatctatc agatgagtat tcacacctat
     2101 ttatggcaat atcaggtaaa ttatcagcag ttatttgcat aaatgaccct ttacgaaaag
     2161 aagcaaaata tgtaatttca aatttaagag aatgcggaat aaaaaagatt gtgatgatga
     2221 ctggagatag cgaaaaaaca gctaaatcta tagcaagtaa agttggtgtt gatgaatatt
     2281 attcagaagt cttaccagaa gacaaagcca attttgttaa aagtgaaaaa ctcaaaggtc
     2341 gcaaagtaat tatgattggt gatggaatca atgattctcc tgctatttca gaatcagatg
     2401 tcggaattgc aatgagtgaa ggtgctgaaa tagcaagaga gatttcagat attaccatat
     2461 cagcagataa tttgaataat ttaatcgttt taaagcagat tagtaataag cttatgaaaa
     2521 gagttgattt aagttctaag tttattatcg gctttaattt aggtttgatt ttacttggtg
     2581 taggtggatt tgttagacca agtacatctg cctttttaca caacgcatct actgtcggaa
     2641 taagtttaaa cagtatgaca aatttattgg aaaacaccaa tacttataac taccattaat
     2701 ctccattaca taaaacatat gatataaaaa atttataatt catcttttta aaaaaatatg
     2761 tcttaaaatt agcttttttc taatcaaaat tatataaagc atactttaca aattttaaac
     2821 tcaacttatt tctatttttt acaaaaaagg agatgattca aattttcatt ttgaaacatc
     2881 cccttttgta aatttcttta aaatttatat attaattata ttttcaacca ataattgtat
     2941 tttcaaccaa tctttcttca tagcatttta aatcattttg ctttagataa ttaaattcag
     3001 actctacata aataccacag cctaccaatt caattgtcaa attaggtata ttttccttta
     3061 gtatactagt ctgctcataa ataattcttt ccaataaatc aacttgtaat atagaaaaat
     3121 gcttcataat ctccccatca ctatctatat ctttcttgat ttcataccaa ctctttgaca
     3181 aaattccctt caaatcaata taccctagac tcctcaatat atctatacta tcgctccatg
     3241 catacttact aggtttatca aagtatgact ctagtttctt cttctgctca tttgtaagtg
     3301 aatcataaga aagcttccta ttaaaatgtg ccttcaaaga aatcttagcc atagaatatg
     3361 gacttctacc agagtttaat cctgcatttt tgaacttttc aattccttta tcttctactg
     3421 aagaccatat tgagtttatt gaatctgaat cattgtattt aacatcaaga ccatgtgtaa
     3481 tatttatata gttttgtgga aatacatatt gataatagac atctttttta tcatcatata
     3541 gagagaagta tccactatca tataaatgaa tatgcacctt tacttttaaa ctatcctcta
     3601 aaatatttcg tctaaggttc gggatatttg catacatggt tacatatttt atggcatcaa
     3661 agtttttatt taatggaact tcaaaactaa tttcatctcc tgtcaaaagc tttttcactt
     3721 cttcttcatt acaatcatat agagaatatg tattttcaaa tcccacacgt gatttcccat
     3781 ctaaactgcc tgttaatgct accttcaaaa tatggttatc tgttttttgc cattggtaag
     3841 catcttggtc aagaaactct ctaatctgtc tattttgctc tttcgcctga tttataacct
     3901 cgttttcatc ttctgtaatc cctacatggc atctatttaa tatatttact atattgcttc
     3961 caaatgggaa tgtccatagt tgaaaagctg ctgcctcaac ctgacacaag tatctaacct
     4021 gatttaattc aatttgatgg ataagttttt tctgatattc attcatctga ttaccactat
     4081 ctgacatttg ataaatcaat tctcccattg caagattatc ttttttctta tcaatcttat
     4141 cagtaatgat aatttgagtt tccatcatat cctgtacttt tttaaatatt atagaaatct
     4201 cctctgaatt ttccattttt aagcttccaa acttcgtgct taattcagtt aaaacttcct
     4261 tcatctttaa tttacttatc tcattttcaa aaatatcttg atttttaact gtactatcga
     4321 atttttctac aaatggtata acagattctt tcaaagtttt atctttaaat tccaccattt
     4381 gagtattcaa ttcatctaat ttcttaatat tattttcttt atctttaatt gcctctttaa
     4441 ctacctctat tttactctca aaactagatt ttacattaag acaattatta acaccactaa
     4501 tcgcagtatt tataagagaa caagcagaac ttccaatact caatgcattt ttaattttag
     4561 atgtcttttg ctgtctttca atagcttgtt tacttttctc tagtgcagct aacttatctt
     4621 tttgctgttt attattgtaa tttgcctcca acatacctat ttcttttttc tggatttttg
     4681 tgtaaatttc cttatactcg ctttcactta acccctcttt tgctctttga atatcgtcag
     4741 ctttgtctgc atagttatca tcatctatag acttaactat aatctcctta atttggtcaa
     4801 atttagttct tctttcttca tcaacacctg ccaaattata agtcatttta tctaaagcat
     4861 tttttctatc ttcacttagc tgttctccaa gtacaaatct cataccatca gaatccaatt
     4921 taaaatctga aaaattaacc atcctgttag tccatttgta ttcctcttct ttagatgaaa
     4981 gattttcctt caaagatttt gcactgtcaa atgcccctag acaagcttga ccaacaccac
     5041 taaatgcagt cagtaaactc aatgcgcttt gtattccaga aagaattaac tgtgttttca
     5101 tttgttcctc aagttttgcc tgtttctttt ttagttcctc tatgtcttct tgttcatctt
     5161 ctttcatctt tataatttct tgaatcaaca ggttcatttt tgcattaaca gaaagcattt
     5221 tattctcaag ttcatttttt aaaacctcta tttgttgatt tccagattca atttgagtta
     5281 ggatactttc cttatatgta ttgaaatatc cttcttttaa ctcatctttc ttcccttgtt
     5341 ccaattctct taaggtctta tccagataat ctgtcaaaga acgaatatct gtaacacgat
     5401 ttcctccaat ttcactttct tcaatcatct gcacataaaa tgctgtcttc tgctcaagtg
     5461 caaataaaat catactccat tcgctaaaat tctgattttt tcctacaaaa gattctattc
     5521 tatcagactg catcaattta tttataaggt attcatagat ttcctttgct tctttataaa
     5581 attctttctt tgtattcata tcatccagag aaagtactgc tttatttttc ttctcaaaac
     5641 tatagtactt ctgaagtatt tctctattta attgcatctc tattttctca actgcatgaa
     5701 aaatttcata aatatgtgaa agttctaaaa tatcagcttc taaaattcct actgcacaca
     5761 acagtctaag atttctataa cctttaattc cagaaaaacc aaatctctcg aaaaattcat
     5821 agaagaatgt atctattgac aaagaatact cctgctttaa caattccttt tcttttagtg
     5881 catctccaga gtgaccagct tttccctctg ctccggctga acctgaatct tcacgtttgc
     5941 taattgtcca gtccttatgt tcttcataaa gagtatttaa tttctctcca tcatctgctg
     6001 cttgcttctg atttaaagca tgattaaaca catatctatc aaaataatag tagtttctat
     6061 cactattatc cattggagga gaggtaccta tatatcttat tgtttcttca tatatacctc
     6121 taattccacc aagacctcct gcaccaccag ctcctccaga gcctcctttt cctgctaaac
     6181 catgatttcc atctttttta cttatagcac tttttaataa aggagctttt ccaaggagat
     6241 aaacctgtcc agacttgctt ccaagacctg catttccacc attacctcct gtgcctccag
     6301 ttccaccttg ttttcctttt tctgctttta caacatagta ttttgtacct ttaacattag
     6361 caaattcttt tgactctttt ttagaaccta ttttagcatt tgccccagct tctccagtta
     6421 tccctgtatc tccttttttt ccatcttgtc catttccacc acgtccacca tctacgtaaa
     6481 gtttaagttc tcctcttttt tctatttctt taaaagataa tatgatatca cctgaagtac
     6541 ctgcattatt gccatttctt ccattcattc cgtcgtaaat agaactttct ccaaccaatt
     6601 tttctgcatc cttaccagat acgttgattg aataagtccc ttctggtata tgtaattttt
     6661 ctgtaagtag tacaatattc ttacctgaga agacttcttt ctccatatta cagtcaattt
     6721 tcaactcaca atctccatac atatatatag atgacaaaat attaagttga taaccagata
     6781 ttattttagt caaatccgat aaattcactt taggtatagg aatatatata gaaagtacat
     6841 tttctttctc atatgatttt atatatgtac aactttgaat cttctctatc ctatactctg
     6901 catcttcaag ctttttggct tcttcttccc tatattcttc ttctgctatc caatatttga
     6961 tatcttttaa tgtatcttct aaagtatttt ttagcaatga ttttaacaac tcacttagac
     7021 caacaatatg agtctcacta cagtaactat ttaactctaa aagaagacgt gtttcttcta
     7081 atatattcac tttctgtacg ccatcaccat atgaaagttc ttgtacaaac tccataagct
     7141 ctttcatatt attagtccta ctacataaat ctgtatacat cttatctaat tgaatctttt
     7201 tatcttttag actatttata gaagatagaa tggaaataga atcttccata ccttttttaa
     7261 cactttctat ataaggaact aaaagttttt ctaggtcttt ataggttaca tcaacagctt
     7321 tttgtatttc tattttacaa gaagcagtaa gcatcaatcc caaatctgtt ttttcaaatg
     7381 tttcaggtag atttttcatt tcattcaaca acttttctgg ctgtttatct agtggattac
     7441 ataatttaat agatacacca tctgataatg ctacatttaa taagtacact aattccttat
     7501 aaccgtcgta atctttctct tgactatcta ggtcttcttt tgcttttttc aatatatttc
     7561 ttattttttc ttctgttaca ttaccgatta gtgctttagg tattttattg ataagaaaga
     7621 agaaattttc tttatacttt gcataatcac caagcatatc tttcaaattt ttgcctgttt
     7681 ctattaataa tgtatgtcta gagtccagta aggattgata gtctaaaata actaccatcc
     7741 ctttcacctt tgaagatgta gaaatagttt cccttacaag catagcacca gcaatcatat
     7801 actctgctcc acggttatca aaaaaacctg ggcaatcaca taatgaaaaa tctctatttg
     7861 caatatctac aacttctgga cataaagtct tagaatatac accatttcca atttcgacag
     7921 ctgaatcttt tgcagttata tatatttgtc cagtctcttc atccgttttt tcttccatca
     7981 cacagccttt taaataattt atacaagtac tctttccaac gcctgaagca cctaggaata
     8041 acaaaattga cttttctttt aagtcatatt ttctaagctc gtctcttcct tcttccaaaa
     8101 ggtttacgat ttcactataa agtttatttg ccatacatcc atccctttct atatttcgga
     8161 acaatagcct tgatattttt ctttaataag attctcttct acctttgaaa cagctgttga
     8221 taacttagtg tttggagcat taaatcctcc attgtctcct ctatctccat attcagcgta
     8281 ttctcttgct ggtcctgttt taccttcatt ccaacttcca ccactaaatt ctatatgata
     8341 tttaattata ctatccaact tataatccca acttgtaaaa tatcctgtat agtacacagt
     8401 cttatctata ccacttggag aaaatgaaag tgtattgtat ccgtgatagc caccacttcc
     8461 tccatatcca cctgaacctg gtctaccatt tggacctgct tctccatctt tcactgttat
     8521 atcacaatga ttaattattc tatttttttg ttcctctgaa tctgaaatga agtaaatatt
     8581 acctttctta ccagcatttc cacctcttcc agcatttcca ccagctccac ctttttcacc
     8641 ttttttgcca cttgtacctt ttgcaaaata ccctttaaac atctgtccgt ggaaataact
     8701 tgtataccct gcatcagctc cattacttcc agaagctcct gtttcaccat ttttcccatc
     8761 tattccttta gaaccatttc ctccatttgc aatcagtgtt aaacgataat ttctaatttc
     8821 ttctttaata tataagtaaa tattacctga atctctacca tcttcaccat ttttaccata
     8881 catagaacta tctacaagtt ctccgctctt tccacttaca ttaattttta cattactacc
     8941 tacatcaaga ttgttacaag caagaataat atttttctct gatgcaaagt ccattccaag
     9001 gttatcatcc atataaatag tatctttagc aaagaacata aatgtagaaa cattgtcatc
     9061 tacttttcta tttttgaaat attccaatac actgctaatt actaagtttg gaattaatgc
     9121 tcttatttca atacctttct tatcattaat attaattgtt tttactataa atggatttaa
     9181 aatgtattta ccaataaatt ctctaattat ctcattacct tcttctccat atgcacttaa
     9241 tcttgttata ctgtcttcta actcttcatt ttgtgtaact gtaacatttg tcaaaattga
     9301 attaaaatca cttacactat atacataatc ctttttattt gcaacttcca ttaatttttc
     9361 tctatttggt aatgtaaata cctgtttttg cacttcataa gaaactaaaa ctttttctaa
     9421 attctttctt attataatga agttttgttc cattatcttc ttacttgcct tttctataat
     9481 aaattccata tgcacagaag gtaataaaat ttccccagtt ccatgttctg tatatttact
     9541 taaagcatca attatatcta agtttccttt tatcttattt tgtaatttca tgcaactatc
     9601 ttgtaagaat aagccacttt gtttggctaa tacgttgata aatctgtcta tagtaagact
     9661 tgttgtactt tccaaccagt ttttaaatac ttttacaacc tcatcatatt ttgctatttc
     9721 ttgaatcatt gttatacttc caataatact gataaaatct tctgtatacg ccttaacata
     9781 atcttctagg ctagatacga tattgttttg aatttctttt atcaacgtat ctaaaactaa
     9841 tcttgcatct gcactaattg gatactggaa tgctgatgtc ttatctttaa cttcatctaa
     9901 ttctagtact tgctttaata aaccgtccct ctcatctgat gcaagtggct tacaaagatg
     9961 aatatttttt ccattatctt ttagcaattc ttcaaataac caagcttttt cctctatatt
    10021 actgtctaaa ttttcgcata attgttcata ttttcttttt ataacattat atatttgttt
    10081 ttctgttctt cctaagaaac tttttgaaat aaaaaaagtt atactaccct taaaattttc
    10141 tttatgaaga cacatattta actgttggaa caggtctagt acttttgtaa gtctagaatc
    10201 taatatatct gcttctggta tcaatacaat tactgcacat atagatgcag aatttttaaa
    10261 tacttcacct aatgaaactg ctgcgctaat atcatgggct actcccctat tgtcgctaaa
    10321 acctgcagta tcacataatt ttgcatccat tccttctatt ggttttctca tatttacaat
    10381 gttcgggtat aaagtttgag aaacagctcc tgaaccaatc tctgccacag ggtctaagca
    10441 atcaatatat gatataccag tatcttcatc ttcgacttcc atcattacac atcctgcaag
    10501 atagttaatt gcagtacttt tgccacatcc tgtcccacca agaattagaa ttaaattttg
    10561 attttcagcc ttatttattg ctacttttcc ttcatttaat aagagtgtta tttcttctaa
    10621 aagttgattg ttattttctg gcatttattt tcccccttgg ttatatattt tatttaaata
    10681 aagtttaatc ccttaagtag attacaaagt ttttagacta tatttaaatt tgttttttat
    10741 tttttatttt taataaattt gcattttcac taaatttgta ttttcactca ataattattc
    10801 ttctttgttt attaaaataa ctgtgttgta taatataatc tttaccaaca cagttattct
    10861 atttaatgcg cttattttat tgtattttat gtaatacagt tgttttttat attatatgtc
    10921 cattattttc ctatggttat tacatataga tttttaatta tatttgtacc attaatttaa
    10981 acattcctat actactgctt aagttttaca cctataccag cttgaatatt ttatttttat
    11041 ttgcttaaat agttcaacta tactggttta aataggttat ctttatttgc ttaaatagtt
    11101 caactatact ggtttaaata ggttatcttt atttgcttaa attagttcaa ctatactggt
    11161 ttaaataggt tatctttatt tgcttaaatt agttcaacta tactggttta aataggtttc
    11221 ctttagttta aataattcac ctatacctac ttgaatagtt cacttttatt tgcttaaatt
    11281 ctataccaat actggcttaa acattatact accatgattg tattgtctat cttcaactac
    11341 aataaaaaca ggttctaaat ctttagtaga tgttattttt aattctaaaa aaacattatc
    11401 agttggtaat atttttacat cataattatt taaattatta ttagtgatac tattaaatac
    11461 atcaccttga cgttcaaaaa aaacattatc aactattaca aaataaacat cttcttttct
    11521 actattttca acctctatag tattttgttt agttacattt agtctcatct tccacctcct
    11581 attaatatta cttaattata ttaatacttg taattgttgc attatgttca tcacaaggaa
    11641 gaggtttaaa aacaactatc tctgctaaat aattctgtgg aggatttgta actgaagtag
    11701 cattgcaaat aaatttaaaa tttgttcctg ctacaacttg agtagaaaca ataagtggtt
    11761 cataaccaac cccttctaac attcctacag cttcattaaa tacttttaaa tcttcttctt
    11821 cgacagctct gaattttgac catccaccaa caaaaagact catataaaaa cctcctttat
    11881 atatatattt atttatatat agtagtacca attttctcaa tattcaatat tttctgtgta
    11941 actggtcaat gaaaatgcat aactggataa aaatacttat aaaataactt aactttacat
    12001 ataaatagct tactttacat gtaataagat tattctacaa tatgaaatac atcttgtttt
    12061 gaatatattc taaatacaat aatggatatt ttcaattatt atccttagaa aatatccatt
    12121 acttaacttg ttttatttaa aatcacatag agactttatt atttttttta ttgcatgaat
    12181 agctatttca ggtatcataa ggtgatatac cccctccttg aaaccacaaa aaacatgaca
    12241 aactttacga atcttggctt aaaaaactac aggtacattc cttatttgtg gattggagta
    12301 gccataacaa gcaaatttta caatttttat gatgacaaaa tcaataaaat cgcttagtat
    12361 ataacacgaa acactacttg ttgctattaa gaatagttag ataggaagta tgcattatac
    12421 caataaagga atcaataaag aaagttaaaa catccctaca aatcaaaaat ctgttacatt
    12481 ttctatattt aaacgttatt tacttacaat tggagaaata acaggttttc cttctcggtc
    12541 aagtaaaggc gtaaatccgg ctgcatttcc ataatagtgg aatacatagt tcacacctgt
    12601 ttctttatcc acccaaatct ccgttgcatt tatttttcct tgtgaatata ctttttcaaa
    12661 tctatctttt cccattttat aatcccccat atttttgatt ggtctatacc ttcttcactt
    12721 aagtcgaaaa aatacataac ttattttttt aattctaata tgaacacgta aaaatgtcaa
    12781 acagcttatt taatttcata acttcatgtt actgttcgta accttgtttg tttacttaca
    12841 ctacattaca gcaccatttt accctttaca tgattgtatt gcacacagca aaaatgctta
    12901 ctttattgga tttttcaact aaaaaaaggt ttttttctcc acagaacatt tactattttt
    12961 tataatatat ctaattttac tctcatatca acatttaatg aagatataac ctttttcaaa
    13021 tattgtaaag actccttaaa aatattagaa aaagattctg caaatctctc aacatctcct
    13081 ttttttaaat acctaagtat ctcaaaacat acatcaaaac gtgttttcaa aatttcatta
    13141 tattcttcat gaaaaaatct ctctaaatag attccaaata tcatatattg ttttaaatgc
    13201 aaaaatgttt cctgtaatac ataaatttgt gtataatcta ctatcttaca aagtaaaaca
    13261 aaatctggat aaaccttaca ctcttcacaa ttattttgta agtaccttaa atgagtttct
    13321 attttatcta cagctatcaa atccatttta tttcctagta aaagtactac atcctcaaga
    13381 gtaatcgtaa caaactccat agcatccaaa agcaaactca accttttagc tccttcttct
    13441 gtatttatat aatcatcatc atattcagaa aaaagtgtta catatgttcc cttgccatta
    13501 attgttttag caattcccaa ttcatttagc tcattatagg cacttctaac tgttggaagt
    13561 gatacattat atctattaat tatcgaagta attgatggta gacaatctcc tattttaata
    13621 ttgccttcaa aaatttgaca aattacatct gaaacaatta agtcatataa ataacatttt
    13681 tccaacgtta cagaattaaa actacttgta tctatacttt gtggagcacg attttctact
    13741 attttaagta tggattctct acaagcttta tacatatatg ttaatagttt tttaaattca
    13801 attagattcc cgtccaatcc atataagtaa gtttttctta cctgctctat gtatttatta
    13861 cgaaaaaagt ctatacaaca attatccaag ttatcgaaat tataggccaa ttgtgaaata
    13921 atgacatcat gctgaataat ctcacaaaaa tggtgaatca ggaaattatt tgttttactt
    13981 attagtttat ttatatattt tagcctttgt tctttaaaga ctaaataatt agaactattt
    14041 ttttccatac aatcgataat ctcgtttaat tcttcaaagt ctttagatgt aaatctttta
    14101 atattgtaca tagcaataga aggaaatatt aaactaaaaa tcttatatat ttctgatatt
    14161 tgtaaaatct tctcatataa taagtcagat tctattgatt gtttactcgt actctggatt
    14221 aaaactggtc tagaaccagc ttttgtctct ataaagccct tttctgagag catttttatt
    14281 acagttttta tagtattttt tgataccata tattcttctg acatgctttt tatagaatca
    14341 agcctatctc caatagtaat tttaccagta taaatttgtt gaattatatg ctcaaaaata
    14401 attaaatatt gtggttttct cttcatattt ttcctcttcg ataaattaga tttattgttt
    14461 tttgtaaggt atatttactt ttatttaata gggcaaaata gttgcttatt ttttcctcat
    14521 aatctataat taatataaac catttatata tatggtctaa gttttataat actgtaatgc
    14581 agtaaaatag catattgtag ctatactaca gcaaattaac ataccattgt agtatattaa
    14641 ttggaataat tttaagtact tcaaaattcc agcaaaacat atatgtgttt ttgatattat
    14701 gtatattcgt taatagaata gctatacttg ttttacataa taaattatat gatacttgct
    14761 atatgtaatt ac
//
LOCUS       DAEQCW010000093        14542 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.094, whole genome shotgun sequence.
ACCESSION   DAEQCW010000093 DAEQCW010000000
VERSION     DAEQCW010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14542)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14542)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14542
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.094"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            202..1113
                     /locus_tag="KRO40_002795"
     CDS             202..1113
                     /locus_tag="KRO40_002795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBH2093608.1"
                     /translation="MKINRLTEIIVILLNKKLVTAKELADRFEVSTRTIYRDIETLSM
                     SGVPVYMTKGKGGGISLIEEYSIDKAILSKKDKESLIVALKTLQATKYPEINSVVNKI
                     GSIFGEQNFSNWIEIDFTEWGSNFNEDDKFTKIKEAILRRNTINFNYVNSLSSQTNRT
                     VEPLKLMYKSKTWYLYGFCKLKDDFRIFRISRIRNLSIKDEVFSRKIIEEVCLNDSKV
                     IKENTITLKLRFKEKMLFRVFDDFNKDLITKNEDDTYDVITEFPIGEWIYGYILSFGD
                     NVEVLEPKDVRDNVITRLRELSKIYSL"
     gene            1288..1785
                     /locus_tag="KRO40_002796"
     CDS             1288..1785
                     /locus_tag="KRO40_002796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="effector binding domain-containing protein"
                     /protein_id="HBH2093609.1"
                     /translation="MNYEIVEINEKIVIGISKETTNKDGQAVNDIGELWKKFMGKGIY
                     NAIKGKKNDKTIGLYTDYQGDFTSPYSFVACCEVNSNSDKEKNLEELNTNNTVGESII
                     SKVIPAGKYAKFVIVGGQKEVGDFWFEFWQMDFDRTYISDFEEYQCNTFDTKKQEIHI
                     YIGIK"
     gene            2529..2891
                     /locus_tag="KRO40_002797"
     CDS             2529..2891
                     /locus_tag="KRO40_002797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBH2093610.1"
                     /translation="MENKILIVDDAIFMRMIIKEALSKSGYNNLIEANDGEEACNIFK
                     YEKPDLMLLDITMPKKDGLEVLREIKKLDSSAKVVMCSAIGQENMIVEAIKLGALDFI
                     VKPFKTETLVKVVDNALK"
     gene            2956..3573
                     /locus_tag="KRO40_002798"
     CDS             2956..3573
                     /locus_tag="KRO40_002798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheC"
                     /protein_id="HBH2093611.1"
                     /translation="MINYLELDDVHIDALREIGNIGSGNAITALASMINSNVEVLIPM
                     VKILEYNEATNLLGGPENKVVCILLDMKGDINGMFMFLLDESITQLMLSSLFNKEEAF
                     LDEIEAIEISAIKEIGNIMASSYVNAIASMLNMTISVSIPDICIDMVGAVLNVPMIRF
                     SDVGDKVLFIENKFKMSDNYFTSHILMIPEMSSLKEILVRLGLEV"
     gene            3570..4055
                     /locus_tag="KRO40_002799"
     CDS             3570..4055
                     /locus_tag="KRO40_002799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheD"
                     /protein_id="HBH2093612.1"
                     /translation="MNREIVVNIADMKIAYRPNVLVTYALGSCVGVCLIDKVAGIGGM
                     LHVMLPYSKDAINIENKCKFADTGINELIKSMENIGANRIYIKAKIAGGAQMFLGSSN
                     SVIASIGHRNVEAVKKTLLGLNIPILAEDTGMNYGRTIRFYTETGELLVDSINKGKKK
                     L"
     gene            4098..4616
                     /locus_tag="KRO40_002800"
     CDS             4098..4616
                     /locus_tag="KRO40_002800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-binding chemotaxis protein CheW"
                     /protein_id="HBH2093613.1"
                     /translation="MRFPDDPYLDYGLIDEGIKYLKFKVDEQDFGVELEKIIEITGNQ
                     EIIFIPELPTYSKGIINLRGKIIPIIDMRLRLKKDELMTTNCMYIVVTEIKDLVVGFV
                     VDRVDDIVSLEKSKISPPPRVTIEYSDYFVSGVGELEGKIITLLDLEKLLTDKDEVLI
                     DELINGFDCTIM"
     gene            4752..5711
                     /locus_tag="KRO40_002801"
     CDS             4752..5711
                     /locus_tag="KRO40_002801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2093614.1"
                     /translation="MKNKQQGTILVVDDSVLMCDLIDKTLTKDNFKVKKAFNAIEAKE
                     FIEEFIPDIILLDIILPDNSGFEFCKEVKSNARTADIPIIFITSKNTDTDIVKGFGVG
                     AIDYMVKPFSMTELKARVIAHLEVKKSQDKLKKINNELESSLEKLNRLVVRDYLTGLY
                     NRRHIINQLMEQRRINKYSETSISLILGDIDDFKVINDTYGHEAGDFVLTVISSIIKK
                     NCRQIDTVSRWGGEEFLIMLTNTPIEGAKILSERIRKEIKEFDFNYKEHKIKCTITLG
                     VVEVNSNISLEENISLADKAMYEGKNLGKDCSVVSTMKGLKKI"
     gene            5737..7440
                     /locus_tag="KRO40_002802"
     CDS             5737..7440
                     /locus_tag="KRO40_002802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing protein"
                     /protein_id="HBH2093615.1"
                     /translation="MKREVKLSKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSIN
                     DMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKELYGKTRESALNKLEKIG
                     LTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLI
                     NEFQEDIVTRSNSKIVEVKKELQSLILRTIFILSLLIILTIIEYTVIKLKIVIPINKV
                     EKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDSTLTSIAKGDL
                     RVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGA
                     TEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMGE
                     ISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSA
                     KAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVA
                     ITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHLKESEVRESSW
                     V"
     gene            7653..9755
                     /locus_tag="KRO40_002803"
     CDS             7653..9755
                     /locus_tag="KRO40_002803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheA"
                     /protein_id="HBH2093616.1"
                     /translation="MRQMLDMFIFETSLLLEQLDEIMIQIEKEKVFTHNNINETFRIM
                     HTIKGSASMMGLDNISALAHSVEDLFYAIREGKIEVLDNDLLFDLVFQSLDFIRRDID
                     ELQSRGCISSDYSNFIEGIEEYVSTLELSSSMKSKDNANLESTDEKEVIDSNFEYKEG
                     SDVVKIIFEQGCMMENVRAFMLVFELRDYCEFIDFYPKDVETNAESTEYIKSYGFYIQ
                     FVAKEDKAIVYKTIEDNLYVKEYINISKKEIEMKNTSNNDAVENKLKDNNKVSKSYQN
                     NYTEDEIQEDVLNEKTDMEKDSLSEENEHLPISKQSIMSVNLEKLDLLQNIVGEIVIM
                     ESMVVNSVNSTGVDIDNFNKATRQLHKLTDELQDIVMSMRMIQIAGVFQKMHRIVRDM
                     NKKLDKNVELITIGAETEVDKSVIDNLAEPFMHLIRNAMDHAIEPIEERIAKGKEEVG
                     KIVLSAENLGGEAVISISDDGRGIMRDKILAKAKEQGLLKHQSNEYTDDEVNSLIMTP
                     GFSTKESITEFSGRGVGMDIVRKSIEKVGGSIEVKSKQDEGTTFTIKIPLTLSIVEGM
                     KFKVGDSLFTLPISSIRRTFKLTDLNQIITEGNKTELITIYGACIPIIRLHKIYNIQT
                     KVTNLMNGNMIIIENEHKAVCIFVDEIIGNQQVVVKPFPVYFNRFNIKNKGLSGCTIL
                     GDGSISLIIDADSIIEIY"
     gene            9768..10208
                     /locus_tag="KRO40_002804"
     CDS             9768..10208
                     /locus_tag="KRO40_002804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheW"
                     /protein_id="HBH2093617.1"
                     /translation="MAKDEIIKQVLTFYVNDVIYGIELENVIETIRFQSITYVPCLPT
                     YISGVINLRGRIIPVINMHIKYNLPKADYNERTCIIITKVDEYQVGIIVDKVVDVIHI
                     ENLNLLETTNSNNTNINKDIKEIAKVEDNSILILDIRKFLINSI"
     gene            10244..11047
                     /locus_tag="KRO40_002805"
     CDS             10244..11047
                     /locus_tag="KRO40_002805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-glutamate O-methyltransferase CheR"
                     /protein_id="HBH2093618.1"
                     /translation="MIKLTDEEFIVLVNHVKKEYGIDLSKKRALIEGRLYNTMIEKKL
                     SSFSQYMNLLFKDKTGNEAINLINRLSTNHTFFMREPQHFEFIQNSILPFWEENNKIR
                     NINIWSAGCSSGEEAYSIAMTLDDYFGYNKELWNIKIIATDISTNSLEKAKRGIYIES
                     NVNNVPELWKKKYFIDNKDGTFKICDKIRKSVIFKPFNLMNDFSYQHFDLIFCRNVMI
                     YFDLKTREELINKFYNATKKDSFLFVGHAEVINRSSTKYKYVKPAIYKR"
     gene            11087..11683
                     /locus_tag="KRO40_002806"
     CDS             11087..11683
                     /locus_tag="KRO40_002806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheB"
                     /protein_id="HBH2093619.1"
                     /translation="MERFNNMVIAIGASVGGTEAILEIIKDLPKSTPGIVVVQHMPAI
                     FTYMYAQRLDKQCIMNVREAKNNDRVEQGNVLIAPGGYQMKLCTDKQGYYVTCEKGER
                     ISGHCPSVDVLFDSVAEVAGKNSIGIILTGMGYDGASGLLKMKENGSFTIGQDENSCI
                     VYGMPMVAFDRGSVMLQLPLGEISNCLIRHINILKQKD"
     gene            11789..12652
                     /locus_tag="KRO40_002807"
     CDS             11789..12652
                     /locus_tag="KRO40_002807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 and DUF4163 domain-containing protein"
                     /protein_id="HBH2093620.1"
                     /translation="MKFFKVDTKAKVLRYVFVLTLTIMAVLAIKHDYKYNNLRKDASI
                     NLNSNKEAVTVMSNQSLPKGNTNSKQTLSVSTIGSKTIVKNDEYLESTINMPVITNSN
                     KIVERSTNDKIKNDIFEFYNKSYKEAKQYLKDNPDEKNKFVANVDFELKKNTDSALSI
                     KVRYYTYSGGAHGFYQDIAYNVDMRTGKFLELMDLFKDNTKYKEVIDEEIKRQIAELE
                     KKDEENIGIYNFKGIKENQNFYLQDENLVVYFDLYDITPYAAGIPEFSINKALISSML
                     KPEYVDLFDLK"
     gene            12719..13708
                     /locus_tag="KRO40_002808"
     CDS             12719..13708
                     /locus_tag="KRO40_002808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="HBH2093621.1"
                     /translation="MLLLKKDDIKKVFTMRDAIEADKEAFRIYCEGKSVNPLRTNISV
                     PSQDASMLFMPGYVEELGCGGIKIVSVFPKNAQKGKPVIPATVLLLDGETGEVSAVLD
                     GTYVTQIRTGAASGAAIDVLAKKDSKIGALIGLGGQGEPQLEAMIEARNLDEVRVFSR
                     NKESREKFAEEMNLKLSKYNTKIVAVESSDEAIDNADVIVLATPSKQPVLNGNLVKKG
                     ALISAVGSYMPDMQELCPNCLTRASKIFFESTDAVLSESGDILIPLKEGKISKDDFSG
                     DLGNVINGTIPGREDDDEIIVFKTVGIGVQDVVTAKRIYDKAKENGIGIDWKW"
     gene            13800..14411
                     /locus_tag="KRO40_002809"
     CDS             13800..14411
                     /locus_tag="KRO40_002809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2093622.1"
                     /translation="MKMVKKLILSTIMALVLVLTIGCSNAEEKVKSNFEANLAALEMY
                     KYDEKGISDALTEAEYKQIQTYNSKDKVSMIAQLTPLYGKENAEKIYETIVKLIQGVE
                     KTVTVESSSKDKITLKVVSKALDTSKVMSEANTLVKSYVTDEKNYDKKEKEVQDDMTK
                     MIIDLYNKKPTKEVTTMITYTKKDGKWQPPSNIQKLCEGIYTI"
BASE COUNT         5929 a         1366 c         2686 g         4561 t
ORIGIN      
        1 ataacaaatg agatgataat aagtaaattg atatagtaat aaataaatta agatgataat
       61 atccaaagtg agaaagataa tagaaagtaa ataaaatcat gtaaaaataa tttagataag
      121 attctaagat tttatttatt taaaaattag tatgattaat ttagattaaa taaatttaat
      181 aattttagta ggtggtaatg aatgaaaata aatagattaa cagaaataat agtaattcta
      241 ttaaataaaa aattagtaac agctaaagag ttggcagata gatttgaagt ttctacaaga
      301 accatatata gagatataga aactctgtct atgtcgggag taccagtata tatgacgaaa
      361 ggcaaaggag gagggatatc tttaatagaa gaatattcta tagacaaggc tatattgtca
      421 aaaaaagata aagagagttt aatagttgca ctgaaaacat tacaggcgac taagtatcca
      481 gaaataaatt cagtagtaaa taaaattggc tcaatatttg gagagcagaa tttttcaaac
      541 tggattgaaa tagactttac tgaatgggga agtaatttta atgaagatga taaatttaca
      601 aaaataaaag aagctatttt aaggcgtaat actataaatt ttaattatgt aaatagtttg
      661 tcaagtcaga caaacagaac tgtcgaacca ctgaagctta tgtataagag taagacttgg
      721 tacttgtatg gattttgtaa actaaaagat gattttagga tatttagaat tagtaggata
      781 aggaatttat ctataaagga tgaagtattt tcaagaaaga taatagaaga agtatgtttg
      841 aatgattcta aagtaattaa ggaaaatact ataacgttga aattgaggtt taaagaaaag
      901 atgcttttta gagtatttga tgattttaat aaggatttaa taactaaaaa tgaagatgat
      961 acatatgatg taattacaga atttcctatt ggtgaatgga tttatggata tattttatca
     1021 tttggtgaca atgttgaagt acttgaacct aaagatgtta gggataatgt aataactaga
     1081 ctaagggagt tgtctaaaat ttattcatta taatataatg ctagattaaa gattttatta
     1141 aatatataat atcttgcatt tagtatataa tatctcactg agtttaatta tattaaaaat
     1201 atgacataaa ggtgtcgtat attataaatt ataattgaat tagttcaaaa taaaatagat
     1261 taataaaaac aaagtgaggt ataaagtatg aattatgaaa tagtagagat aaatgagaaa
     1321 atagttatag gaatatcgaa ggagactaca aataaagatg gacaagcggt aaatgatata
     1381 ggtgaattgt ggaaaaaatt tatgggcaaa gggatatata atgctataaa gggtaaaaag
     1441 aatgacaaga caataggtct atatacagat taccagggtg attttacaag tccgtatagc
     1501 tttgttgcat gttgtgaagt aaatagtaat tctgataaag agaagaattt agaagaatta
     1561 aacactaata atactgttgg agaaagtatt attagtaaag ttataccagc aggtaagtat
     1621 gcaaagtttg ttatagtagg aggtcaaaaa gaagtaggag atttttggtt tgagttttgg
     1681 caaatggatt ttgataggac ttatataagt gattttgaag agtatcaatg taatactttt
     1741 gatacaaaga aacaagaaat tcatatttac ataggaataa agtagatttg ttattactat
     1801 attgaatgaa atattgagta tagtacattt attatagata gttttattat ttataactat
     1861 aagcagtaaa tctgtaaaag atttactgct tttttagtaa ttaatagtat cagtatcact
     1921 ttgaatcttc agacatattc ttcatttaat attgtttatt gataaatgat acttgtaaat
     1981 ataatgattt gttatttaat ttaaaatatg aaaaaaagta ttataaacac attagaatac
     2041 ttctggattt atgagtatac aatttgaaaa atataaaaaa taatttataa agctaaatct
     2101 aatttaatcg ataatacata tagagaaata taattaagta aataaacaac tatctattag
     2161 atattgagaa agtcaaatcc tatatgaatc tacagaaatg attttaatga atctgaaaat
     2221 tttttttata caaacataaa aaaggtataa agttgtttta ttataattta attacttttg
     2281 ataacttttt atgttttata caattatatt tttaataact cgtcaaaacg ccaaacatat
     2341 attacaatag atatataagt ttttttgttg acaaattatg ttaagagaat taagtataat
     2401 atggcataaa taattacttt tatttatcaa tgaaatgtat ttattgtgta gcgaaaaata
     2461 gtcagatagt atagacaata actgaagata aaagcgttta ttgttgtaca tatggaggag
     2521 ttagttttat ggaaaataaa attttgatag tagatgatgc tatttttatg agaatgataa
     2581 ttaaagaagc tctgagtaaa agtggctata ataatttaat agaagcaaat gatggagaag
     2641 aagcgtgtaa tatatttaaa tatgaaaagc ctgatttgat gttgcttgat attacaatgc
     2701 caaaaaaaga tggtttagag gtgctaagag aaataaaaaa gttggattca agtgctaagg
     2761 ttgtaatgtg ctctgcaata ggacaagaga atatgattgt agaagccata aaacttggag
     2821 cgttagattt tatagtgaag cccttcaaaa cagaaacatt agttaaagtt gtagataatg
     2881 ctttaaaata aaagtgtaaa tatacactaa tacaatgaaa agcaaataaa tgcaataata
     2941 aagggagggg tttatattat aaattattta gaacttgatg atgttcatat agatgctctt
     3001 agagaaattg gtaatatagg ctctgggaat gcaattactg cacttgcatc catgataaat
     3061 agcaatgtag aagtattaat acctatggtc aagatacttg aatataatga agcgacaaat
     3121 ttgcttggtg gtccagaaaa caaagtagta tgtattttac tcgatatgaa aggtgatatc
     3181 aatggaatgt ttatgttttt gttggatgaa tcaataactc aacttatgct aagttctctt
     3241 tttaataaag aagaagcttt tttagatgag attgaggcaa ttgaaatttc agcaattaag
     3301 gaaataggaa atattatggc aagttcatat gtaaatgcta ttgcatctat gttaaacatg
     3361 actataagtg tttcaattcc agatatatgt attgatatgg ttggagctgt tctaaatgta
     3421 cctatgataa gattttcaga tgttggtgac aaagtcttat ttatagaaaa taaatttaaa
     3481 atgagtgata attattttac tagtcacatt ttgatgattc cagaaatgag ctcacttaaa
     3541 gagatactcg tgaggttggg attagaggta tgaatagaga gatagtagtg aacattgcag
     3601 atatgaagat agcctataga ccaaatgttt tagttactta tgcacttggt tcttgtgtag
     3661 gagtatgttt gatagataaa gtagctggaa ttggtggaat gttacacgtt atgttgccat
     3721 atagtaaaga tgctattaac attgaaaata agtgtaaatt tgctgacaca ggaataaatg
     3781 agctcattaa atctatggag aatataggtg caaatagaat atatataaaa gcaaaaattg
     3841 ctggaggtgc tcagatgttt ttaggaagta gcaattcagt aattgcaagt ataggacata
     3901 ggaatgttga ggcagtaaaa aaaactcttt taggattaaa tattccaata ttagctgagg
     3961 atacaggtat gaattatggt agaacaatac gtttttacac tgagacgggt gaattacttg
     4021 tagattcaat aaataaaggt aagaagaaat tataatatat atttcataga aagtgtattt
     4081 taggagggag gtattaaatg agatttccag atgacccata tttagattat ggactaattg
     4141 atgaaggaat taagtatcta aagtttaaag tagatgagca agattttggg gttgaacttg
     4201 aaaagataat agaaattact ggaaatcaag aaattatatt tattccagaa ctacctacat
     4261 attctaaagg cataataaat ctaagaggaa aaatcattcc gataatagat atgcgtttga
     4321 gacttaaaaa agatgaatta atgactacaa attgcatgta tatagtagta actgaaataa
     4381 aggacttggt agttggattt gtggttgata gagttgatga tatagtaagc ttagaaaaaa
     4441 gtaaaatatc acctccacca agagttacta tagaatattc ggattatttt gtaagtggag
     4501 ttggagaatt agaaggtaaa ataattactt tactagattt agagaaactt ttgacagata
     4561 aagatgaagt tttaatagat gaattaatca atgggtttga ttgcactatc atgtaatata
     4621 gggatgtagt tggagtgtta ttataaaaag attgtgatga gaacatttaa gaatatagtg
     4681 gtataattat taagtataaa aattttaaat cattaaaatt tgaatatatt atgtttaaga
     4741 gaggtttgta tatgaaaaat aagcaacagg gaacaatttt agtcgttgat gatagtgttc
     4801 tgatgtgtga cttaatagat aaaacactta caaaagataa ttttaaggtt aaaaaagcat
     4861 ttaatgcaat agaggcaaaa gaatttattg aagaatttat accagacatt attttgcttg
     4921 atataatttt accagataat tctggttttg agttttgtaa ggaagtaaaa tctaatgctc
     4981 gtacagcaga tatacctata atttttataa cttcaaaaaa tacagataca gacatagtaa
     5041 aaggatttgg tgtaggagca attgactata tggtgaaacc ttttagtatg acagaattaa
     5101 aagctcgtgt tatagctcat cttgaagtaa agaaatctca agataaacta aaaaagataa
     5161 ataatgaact ggaatcttct cttgaaaaat tgaatagact cgttgtaaga gattatctta
     5221 caggtcttta caataggcga catataatta atcagcttat ggagcaaaga agaattaata
     5281 aatatagtga aacatcaata tcccttatcc ttggtgatat tgatgacttt aaggttatca
     5341 atgatactta tgggcatgaa gcaggggatt tcgtgttaac agtaatatca agtataataa
     5401 aaaagaattg tagacaaatt gatactgtat caagatgggg tggagaagag tttttgataa
     5461 tgctcacaaa tactccaata gaaggtgcta agatactttc agaaagaatc cgtaaagaga
     5521 taaaggagtt tgatttcaac tataaagaac ataaaataaa gtgcactatt acattaggag
     5581 tagtagaagt aaactcaaat atatcattag aagaaaacat atccttagca gataaagcaa
     5641 tgtatgaggg taaaaactta ggaaaagatt gtagcgtagt gagtacaatg aaaggattaa
     5701 aaaagatata aacttacttt atgaaggagt acagatatga aaagagaagt aaagctttct
     5761 aaattagcaa ttgtattgct gattattata gtattggctg ttctagcagg gattttttct
     5821 tctatttcat cttataaagc atttgaaaaa gtagaaaaaa gtattaatga tatgaataat
     5881 ttgaggactc aaagtcagta tataaaagat acaactagag agataagtga tgtattaaga
     5941 agatatgtat ttacaggaga aaaaaagaat aaagatattt atgaaaaaga attatacgga
     6001 aaaacaagag aatcagcttt aaacaaatta gaaaaaattg gtcttacaaa gagcgagtca
     6061 aataaaatct tagaagcaaa agaaatatca gattctttag taccaacaga acaaagtgca
     6121 ataaaggcag tcgaaagtaa tgataagagt aaagctcaaa gtataatttt tggtagtgac
     6181 tatataaact cccaagagaa aatggattct ttaataaatg aatttcaaga ggatatagtt
     6241 acccgttcaa attccaaaat tgtagaagta aaaaaagaat tacaaagtct aatattaaga
     6301 acaatattta tactttccct tttaataata ttgacaataa tagaatatac agtaataaaa
     6361 ttaaaaatag tgattcctat taataaagta gaaaaacact tttcaagaat tgcatctggg
     6421 gacttaagaa caagtataga cgttgaagaa agtaaatctg aaataggact attagtgagt
     6481 tctgtcaaaa agatgcaaag tatgctttta aattacatag accttataga cagtacatta
     6541 actagtattg caaaaggaga tttaagagta gagatagacc aagaatttat aggtgatttt
     6601 aaatcaatta aaatatcttt agaaagtata ataaactctt ttaatggtga tttttctgaa
     6661 ataaatttat cagcagagca agttgcaagt gcttcagaac aagttgcagc aggtgcacaa
     6721 gctctttcac agggtgctac tgaacaagct agttcagtag aagaattagc ttccacgatt
     6781 aatgagatat cagatggaat taagaagtgt gcagatagtg ctagtcttgc atgtgaggta
     6841 tctgaccaat ctgcatcaca agttggtttc ggaagtagat gtatggatga tatgatgaca
     6901 tcaatgggtg aaataagtga aaaatcgagt gaaatatcaa aaataatcaa aacaatagat
     6961 gagatagcat tccaaactaa tattcttgca ttaaatgcag ctgttgaagc agcaagagca
     7021 ggtcaatatg gtagaggatt tgcagttgta gcagatgaag ttaggtcttt ggctggtaaa
     7081 agtgcaaaag cagctcaaaa tacagctatt ctcatagaag aagctattaa aacagtagaa
     7141 aatggtgtca gaattgctaa agagactgca aatgcattgg acttggtagt aaatggtgta
     7201 gaaaaaacta ctaattatat taatggtatt tcttcggctg tacatagtca agaagtagca
     7261 attacacaga ttttatctgg aatagagcaa atttccatag tagtccaaat gaactcagca
     7321 acagcagagg aaagtgcagc agcctcagaa gagatgtctg ctcaagctca aattttaaaa
     7381 gaattagtag aaaaatttca tctaaaggaa agtgaagtaa gagaatcatc atgggtttaa
     7441 attatgaggt gaatattgaa gtaagagaat tatcatgtat ttaaattatg agatgtatat
     7501 atattgaagt aagagaataa ttgtgtattt aaattatgag gtacatatag tgagataaga
     7561 gaatcatcaa ggatttaaat tatgagatgc atatataata gaaaattatt tgtaggtcgt
     7621 aggtgataaa tgtgaattat attgaaccga gtatgagaca aatgttagat atgtttatat
     7681 ttgagacaag tttattactc gaacaattag atgaaattat gattcaaata gaaaaagaga
     7741 aagtatttac tcataacaac attaatgaaa cttttagaat aatgcatacg ataaaaggtt
     7801 cagcatctat gatggggtta gacaatatat ctgctttagc acatagtgta gaagacttgt
     7861 tttatgctat acgtgaaggt aaaatagaag ttttagacaa tgacctatta tttgatttag
     7921 tctttcaatc attagatttt ataagaagag atatagatga gttacaatca agaggttgta
     7981 tatcttctga ttactctaat tttattgaag gaattgaaga gtatgtgagt actttggaat
     8041 tatcaagttc tatgaaatca aaggataatg caaatttaga aagtacagac gaaaaagaag
     8101 taatagattc aaattttgaa tacaaagaag gctctgatgt agtaaaaata atctttgaac
     8161 aaggttgcat gatggaaaat gtgagagctt tcatgcttgt atttgaactt agagattact
     8221 gtgaatttat agatttttat ccaaaagatg tagaaacaaa tgcagagtct acagagtata
     8281 ttaaaagtta tgggttttat atacaatttg tagctaaaga ggataaggca atagtttata
     8341 aaactataga agataatctc tatgtaaaag aatacataaa tattagtaaa aaagaaatag
     8401 aaatgaaaaa tacatcaaac aatgatgcag tagaaaataa attaaaagat aataataaag
     8461 taagtaaaag ttatcaaaat aactatacag aagatgagat acaagaagat gttttaaatg
     8521 aaaaaactga tatggaaaaa gatagtctaa gtgaagaaaa tgaacattta ccaataagta
     8581 agcagagtat tatgagtgta aatttagaaa aattggactt acttcaaaat atagttggag
     8641 aaattgtaat tatggaatca atggttgtaa atagcgtaaa ttctacaggt gttgatatag
     8701 ataatttcaa taaggcaaca agacaattac acaagcttac agatgaattg caagatatag
     8761 taatgtctat gcgtatgatt caaattgctg gtgtatttca aaaaatgcat agaattgtac
     8821 gagatatgaa taaaaaatta gataaaaatg tagagttaat aactatagga gcagagacag
     8881 aggtagataa gagtgtaatt gataatttag cagaaccttt tatgcacctt ataagaaatg
     8941 ctatggacca tgcaatagag cctattgagg agcgtatagc gaaaggtaaa gaagaagtgg
     9001 gaaaaatagt tttatctgct gaaaatctag gcggagaagc tgtgataagt atttcagatg
     9061 atggtagagg cattatgaga gataagattt tggcaaaagc taaggaacaa ggtcttctta
     9121 aacatcaaag taatgagtat actgatgacg aggtcaattc tttgattatg actccaggct
     9181 tttctacaaa agaatctata actgaatttt ctggaagagg agtaggcatg gacattgttc
     9241 gtaaaagtat tgaaaaagtt ggaggttcaa ttgaagtaaa aagtaaacag gatgaaggga
     9301 caacctttac tataaaaata ccattaactc tttctatagt agagggtatg aagtttaaag
     9361 ttggagattc actatttact ttaccaatat catccataag aagaacattt aaacttacag
     9421 acttaaatca aataattaca gaaggaaata agacagagtt aattacaata tatggagcat
     9481 gtattcccat tataaggtta cataaaatat ataatattca aacaaaagta accaatctga
     9541 tgaatggtaa tatgataatt attgaaaatg agcataaagc agtatgcatt tttgttgatg
     9601 aaataatagg taatcagcaa gttgttgtga aaccatttcc agtttatttt aaccgattta
     9661 atataaaaaa taagggttta tcgggatgta caatacttgg ggatggaagt ataagtttaa
     9721 ttatagatgc agatagcatt atagaaatat attaggggat ttaaagtatg gctaaagatg
     9781 aaattattaa acaagtatta acattttatg tcaatgatgt tatttatgga atagaattag
     9841 aaaatgtgat tgaaaccata agatttcaat caataacgta tgtaccatgt cttccaacat
     9901 atataagtgg agttattaat ttgagaggaa gaataatacc agttattaat atgcatataa
     9961 agtacaatct tcctaaagct gattataatg agagaacttg tataataatt acaaaggttg
    10021 atgagtatca agttggaatt attgtagata aagttgttga tgttattcat atagaaaatc
    10081 taaatttact agagacgact aattctaaca acactaatat taataaagat ataaaagaga
    10141 ttgcgaaagt tgaagataat tctatattaa ttttagatat tcgaaagttt ttgattaata
    10201 gcatatagtt agttctgata aattagcagg aggaagtttt tgcatgataa aactcacaga
    10261 tgaagaattt atagttcttg taaaccatgt aaaaaaagaa tatggtattg atttaagtaa
    10321 aaaaagagcg ttaattgaag gtcgcttata caatacaatg atagagaaaa aacttagttc
    10381 ttttagtcaa tatatgaatc tattatttaa agataagaca ggaaatgaag ctataaacct
    10441 aataaataga ttgagtacta accacacatt ttttatgaga gaacctcaac attttgagtt
    10501 tatacagaat agtatacttc ctttttggga agaaaataat aaaataagaa acataaatat
    10561 atggagtgca ggatgttcta gtggagaaga agcgtattca atagctatga ctttggatga
    10621 ttattttgga tataataaag agttgtggaa cattaaaatc atagccacag atatttcaac
    10681 taactcactt gaaaaagcta aaagaggtat atacatagaa tcaaatgtta acaatgttcc
    10741 tgagttatgg aagaagaagt attttataga caacaaggat ggtacattta aaatttgtga
    10801 taagattaga aaaagtgtaa tttttaagcc gtttaattta atgaatgatt tctcatatca
    10861 acattttgat ttgatttttt gtagaaatgt tatgatttat tttgatttaa aaacaagaga
    10921 agaacttata aataaatttt ataatgctac caaaaaagat agttttttgt ttgtaggaca
    10981 tgcagaagta atcaacagaa gtagtactaa atacaaatat gtaaaacctg ctatatataa
    11041 acgataaaaa ggtatttttg atatatgatt ttttggaggc ggtaatgtgg aacgttttaa
    11101 taatatggtt attgctatag gcgcatctgt aggtggtaca gaggcaatac ttgaaattat
    11161 aaaagaccta ccaaaatcaa caccagggat tgttgtagtt caacatatgc cagctatatt
    11221 tacttatatg tatgcacaac ggcttgacaa gcagtgtatt atgaatgtaa gagaagctaa
    11281 gaataatgat agagtagaac aaggaaatgt gttaattgca cctgggggtt accagatgaa
    11341 attgtgtacg gataaacaag gatattatgt aacttgtgaa aaaggagaaa gaataagtgg
    11401 tcactgtcca tcagtagacg ttttgtttga ttcagtagca gaagtagcag gtaaaaattc
    11461 aataggaata atacttacag gtatgggtta tgatggagca agtggacttt taaaaatgaa
    11521 agaaaatggt tcatttacaa ttggacagga tgaaaattct tgtatagtat atggaatgcc
    11581 aatggtagct tttgatagag gttctgttat gttacaatta cctcttggtg aaatttcaaa
    11641 ctgtttgata agacatatta atattttaaa acaaaaagat taatttttta taaataaaaa
    11701 ttaatctttt attaaattat atggataaaa aaccctagaa actccaaata taataagaga
    11761 gatttatatt taggaggaaa atgataatat gaaatttttt aaagtcgata caaaagctaa
    11821 agttttaaga tatgtatttg ttttaacatt gactataatg gctgttttgg caattaaaca
    11881 tgactataaa tataataatt taaggaaaga tgcttcaatt aatttaaata gtaataagga
    11941 agcagtgact gttatgagta accagtcatt accaaagggt aatacaaata gtaaacaaac
    12001 tttatcagta agtacaatag gaagtaaaac aatagtgaaa aatgatgagt atttagaaag
    12061 tactataaac atgcctgtaa taacaaattc aaataaaatt gttgaaaggt ctacaaatga
    12121 taagataaaa aatgacatat ttgaatttta taataaatca tataaagaag caaagcagta
    12181 tcttaaggat aatcctgacg agaaaaataa gtttgttgca aatgtagact ttgaacttaa
    12241 aaagaatact gattctgctc ttagtataaa agtgagatat tatacttata gtggtggagc
    12301 acatggattt tatcaagata tagcatataa tgtggatatg agaactggaa aatttttaga
    12361 attaatggac ttgtttaagg ataatactaa atataaagaa gttatagatg aagaaattaa
    12421 aagacaaata gctgaacttg aaaaaaagga tgaagaaaat atcggaatat ataattttaa
    12481 aggtataaaa gagaatcaaa acttttactt gcaagatgag aatctagttg tatattttga
    12541 tttatatgat ataactccat atgcagcagg aataccagaa ttttcaataa ataaagcgtt
    12601 gataagttct atgctaaaac cagagtatgt agatttattt gatttgaaat agaagattaa
    12661 attaaatgtt atgctataat atttagcata gagacttatt aaaattgggg gtataaaaat
    12721 gctactttta aaaaaagacg acataaaaaa agtatttaca atgagagatg caattgaagc
    12781 tgataaggaa gcttttagaa tttattgtga aggaaagagt gtaaatcctt tgagaaccaa
    12841 tatatctgtt ccaagtcaag atgctagtat gttatttatg ccaggatatg tagaagaatt
    12901 aggctgtggg ggaataaaaa ttgtatctgt atttcctaaa aatgctcaaa aaggcaaacc
    12961 agtaattcca gcaacagtac tattattaga tggagaaact ggagaagtta gtgcagtatt
    13021 ggatggtact tatgtaactc agattcgtac tggagcagcc tctggagcag ctatagatgt
    13081 attggctaaa aaagattcta agattggagc tttgataggt ctaggaggac aaggtgagcc
    13141 acaacttgaa gccatgatag aagctagaaa tttggatgag gtaagagttt ttagtagaaa
    13201 caaggaaagt agagaaaaat ttgcagaaga aatgaactta aaattaagta aatataatac
    13261 taaaatagtt gcagttgaat catctgatga agccatagat aacgcagatg tgatagtttt
    13321 agctactcca tcaaaacaac cagtacttaa tggaaactta gtgaaaaaag gagctttaat
    13381 aagtgcagta ggttcatata tgccagatat gcaagagttg tgcccaaact gtttaactag
    13441 agcgtctaag atattttttg aatcaacaga tgcagtttta tctgagtcag gagatatatt
    13501 aattccatta aaagaaggta agataagtaa agatgatttt agtggtgatt taggaaatgt
    13561 tataaacgga actattcctg gaagagaaga tgatgatgag ataattgtat ttaaaactgt
    13621 tgggataggt gtacaagatg tcgtaacagc aaaaagaata tacgataaag caaaagaaaa
    13681 cggtattgga atagactgga agtggtaaaa tattcaaaat aattctatag ttagacaaat
    13741 ttatgttata atgttgataa ataaattttt tattatttta attgagggag gatgtttgta
    13801 tgaaaatggt aaaaaagtta atattatcta cgattatggc tctagtttta gttctaacta
    13861 tagggtgttc taatgcagaa gaaaaagtaa agtcgaattt tgaagctaat ttagctgcat
    13921 tagaaatgta taagtatgat gaaaaaggaa tttctgatgc attaacagaa gctgaatata
    13981 aacagattca aacttataac agcaaggaca aggtttcaat gattgctcaa ttgacacctc
    14041 tttatggtaa agaaaatgct gaaaagatat acgaaacaat tgttaaatta attcaaggtg
    14101 ttgaaaagac agtaacagtg gaatcttcta gtaaggataa gataactttg aaagttgtaa
    14161 gtaaagcttt agatactagt aaagtaatga gtgaagcgaa cactttagta aaatcttatg
    14221 taactgatga aaagaattac gataaaaaag aaaaagaagt tcaagatgat atgacaaaaa
    14281 tgattataga cctttacaat aagaaaccaa ctaaggaagt tacaactatg attacatata
    14341 ctaaaaaaga tggtaaatgg caaccaccta gtaatataca aaagttatgt gaaggaatat
    14401 atacaattta atttatttta aagacacaaa actatctttt aagcatataa taaaatgttt
    14461 ggaagatagt ttattttatt ttcaaagtat aaattatatt ttataaatga tttattttat
    14521 aaataattta tcttgataaa ta
//
LOCUS       DAEQCW010000094        14328 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.095, whole genome shotgun sequence.
ACCESSION   DAEQCW010000094 DAEQCW010000000
VERSION     DAEQCW010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14328)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14328)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14328
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.095"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            70..1671
                     /locus_tag="KRO40_002810"
     CDS             70..1671
                     /locus_tag="KRO40_002810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp11"
                     /protein_id="HBH2093623.1"
                     /translation="MKMNKKILSLGLAVSLILVNFKSVNASSVVEKIYGKDRYETAAK
                     IADKQTYETVILVNTEKSLADGLSASGLSGATKAPILFTQQNKIPADTNRCLKNIKKA
                     YIIGTEDTISKSVEKELDSKNIEVKRIGGEDRLKTSYLIAKEIATIKKVDKVLLTNAY
                     SGEADAMSVSSVATRDGAPIILTDGKSVPFDVKNIQSYCIGSEEIMSNPLVKNTNSVR
                     IEGTDRFETNKNVIDYFFNSADGFYVSDGYQLVDAIAAAPLTKNSPMVLVNDGSDKTV
                     LEGAKNITSVGEINEKVIQQCINASNSNGQPPTITVGSTEVYKGEKFDTGKLNIVAKD
                     NTGKVLPIEVDGFIDTNRVGTYILTLKATDEWGKSTGKRVEIKVLDDKSHDYNSPEFK
                     KMVSTEMYNLINSYRKEKGKEPLLVSSRLEGMANAWSKYMMDKKVFAHYIDGKNAPQV
                     FSEFGMRSEENIAYIYIDSKNVQTTQDAKDLAKAIFEVWKKSPEYNANMLSNEFYSTG
                     FGLYILSDGQVHATQEFLNGNEGSL"
     gene            1890..3488
                     /locus_tag="KRO40_002811"
     CDS             1890..3488
                     /locus_tag="KRO40_002811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2093624.1"
                     /translation="MKVNKRVLSIGLTISLIMAGAPNINALSSIEKIQGKDRYETSAL
                     IADKQIYDTIILVNTDNSIVDGLSASGLSGVAKAPIMLVQRDKIPTDVEKRLKDVKNA
                     YVIGTEDTIGKSVENQLKNKGIEVKRIGGEDRIKTSYLIAKEISAIKPVNDGDKVFLV
                     NGYTGEADAMSVSSVAARDGVPVILTDGKSIPFKVDGVQCYSLGSEEIMSNELVSKTN
                     SVRIAGKDRFETNKKVIQRFYKGTKKFYVSQGYKLVDAVAGSPLAKDKPIVLVNDGSD
                     KSVLRGADEVTSLGGMDKKVVDQCISSASDKNTMPTITANDVEISVGDKFDNSMLNIV
                     ATDYYGNDLKANIKGNVDINKAGTYVLNISVVDNLGQKSEISVNVKVVVNASTKDSNS
                     YEFKAMVSNEMYDLVNSYRKEKGKKSLRELDSLAGMANAWSKYMEDKKVFAHEIDGKN
                     AAEVFFGFGARSGENIAYLPMNVKSVYTSKDAKEMAESIFDLWKKSSKYNENMLKEEF
                     YSFGFGMHVSSKGEVNATMEFLNS"
     gene            3778..5976
                     /gene="slpA"
                     /locus_tag="KRO40_002812"
     CDS             3778..5976
                     /gene="slpA"
                     /locus_tag="KRO40_002812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-layer protein SlpA"
                     /protein_id="HBH2093625.1"
                     /translation="MNKKNLAMAMAAVTVVGSAAPIFADTTVKEEGYTVVQDKYEKLL
                     KELKAKIKDGTITSVGVEFDGKPITTLAPKADGSDKDAIAEQLETLTKNQLKGLGDGK
                     YVDFKITYGAKAEVPAASLSADDIQKYADQINASEKILVEVAAGSEAGIAKFDSVNNK
                     VIAGDAPLKVKDAVKATVTTNGSNKKVLTISAAAGLSGFSYGTLKDTGASLSDVDAIT
                     LDTTNATITEGDTKVLDFDNSFKFNESTKKVGSLVTPNTTNTPADPGTKTTVRVIKAV
                     EKTIDVSSNSTTKAKDLAKQYVFTDVSDTDPESLSYMLKNINDGKVAVKNSDGDYEVT
                     IFPEGKRLNTLSASSAKTILGDKDTPAKIVLKASTTKKLADYIDDLITYNNSYSNVQT
                     VAGSDRIETAIELSRKYYNSTDKNALYGDPVNNVVLVGSQAIVDGLVASPLAAEKDAP
                     LLLSSKDKLDSSTRAEIKRVMDLNSSTGIKNNKEVFIAGGVNSISKDVENELKDMGLK
                     VTRLSGDDRYETSLAIADEIDINDKAYVVGGTGLADAMSIAPVASQIKDGEATPIVVV
                     DGKSDKLSKEAEDFLDDAQVDIIGGENSVSAKMEDYIDDATGKSPERISGADRQATNA
                     EVIKEYFDKDGVSNYFLAKDGSTKEDQLVDALAAAAVAGNYGSKHNEDGDITTDASPA
                     PIILATDNLSAEQHVAVSKTATTNGAKNLVQVGQGIADSVVSKLKDLLDM"
     gene            6222..8564
                     /gene="secA"
                     /locus_tag="KRO40_002813"
     CDS             6222..8564
                     /gene="secA"
                     /locus_tag="KRO40_002813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBH2093626.1"
                     /translation="MSVLDVILDKTDELEIKKLNNIVDKIDALEDKIQILDDEALKNM
                     TNVFKDKLSKGETLDDILPEAFAVVREVSKRILGMRQYRVQLIGGIVLHQGKIAEMRT
                     GEGKTLVGVAPVYLNALTGKGVHVITVNDYLAQRDKELMQPVYEFLGLTVGVIINGQQ
                     PVERKLQYQCDITYGTNNEYGFDYLRDNMVTQKSEKVQRELNFAIVDEVDSILIDEAR
                     TPLIIAGGGDEGTKLYELANAFIKNIRDEDFEMDRKDKTIALTASGLSKAEKFFGIEN
                     ITHIDNIEIFHHVNQSLRAHKLMNIDVEYVVRDNEILIVDEFTGRIMDGRRFTDGLHQ
                     AIEAKEGVKINDESKTMATVTFQNFFRLYSKLSGMTGTAKTEESEFEATYKINVVQIP
                     TNKPVIRADLHDKVFKTERAKYNAVVEEIIRINKTKQPVLVGTVSIEKSEKLSKLLKK
                     KGVKHEVLNAKQHDKEAEIISKAGKLGSVTIATNMAGRGTDISLGAGDKEEEEKVKEL
                     GGLYVIGTERHETRRIDNQLRGRSGRQGDPGTSRFFVSLEDEVIKLYGGKSIEKILKR
                     MNANEDDALESKALNRAIERAQKGIEGKNFEQRKNVLKYDDTINEQRKVIYDERNKVL
                     DGSDIEEEIQKMVMDIITEAAEKYLKKFRDYHGYFKYLYNTFMPADTLLIPDLDKKNV
                     EEIVNQTYQISKRVYDLKKMMIGIEELAQLEKRVLLQVVDTYWVDHIDAMDQLRQYIG
                     LKSYAQKDPFKEYAIEGYEMFEALNRNIRITTVQYLYKFN"
     gene            8978..10849
                     /locus_tag="KRO40_002814"
     CDS             8978..10849
                     /locus_tag="KRO40_002814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2093627.1"
                     /translation="MNRKNLYVIMAAAMVSTSVAPSFAAEATQVKKQTITKKEATELV
                     SKVRELMAQRYTGGSQVGQPIYEIKVGETSSQLKIITNIDELEKLVNALGENKELLVT
                     IADKGHTTNSANEVVAEAIEKYENSADLSAEANSITEKAKTEATGIYGVATVEASYDS
                     TKDKLVITLKDKTDVVTSKTLQIGIGDEKVDLTANPVDIAGTNLDPSAEGFRVSKINK
                     LGVEGAKNIADIQLAEITIKNSDLNTVSPQDLYDGYRLTIRGNTIANSVGKSISDISS
                     KDSETGKYKFTVKYTDTSGKAIELTVESTNDKELKDVKDALNGNTKVNLIAGEDRYAT
                     AVAIAKETEYTDNIVIVNSNKLVDGLAATPLAQSKKAPILLASDNEIPKVTLDYIKEI
                     IKKSPSAKIYIVGGESAVSNTARKQLESVTKNVERLAGDDRHTTSVAVAKAMGSFKEA
                     FVVGAKGEADAMSIAAKAAELKAPIIVNGWNDLTADAIKLMDGKEIGIVGGSNNVPSQ
                     IENQLADIDKDRKVQRVEGETRHDTNAKVIETYYGKLDKLYIAKDGYGNNGMLVDALA
                     AGPLAAGKGPILLAKNDITNSQKNTLDKKLNLGAEVTQIGNGVELTVVQKIGKILGW"
     gene            10958..11665
                     /locus_tag="KRO40_002815"
     CDS             10958..11665
                     /locus_tag="KRO40_002815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH2093628.1"
                     /translation="MIEATLFFSPHQDDETLSMGSAIIEHVERSDTHVILCTDGSKSI
                     IRKVLDDGGSCSYHIKDVHKYSLSESDFSKNRDEEFKNSCKAMGVKENNIHIENNRAH
                     DGELSKEKARDIMLKYLEKYPDAKVKTVTPYKALGIHEDHRALGEAALELYREGKIKD
                     LRFYVEPYDYNDFKKVNPNVRVWKVLSSQEEKLLNAMDAYKKWNPENGNYAIGYHSVK
                     SHFDELKSNKIQYVHAP"
     gene            11698..13830
                     /locus_tag="KRO40_002816"
     CDS             11698..13830
                     /locus_tag="KRO40_002816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2093629.1"
                     /translation="MKISKRIMSLLTATFFIFALSINIADASSKESLVGSGRWETAIK
                     ISQNGWKDATNAILVNDNSIADALSATPFAKLKDAPILLTQSDKLDSRTKAELKRLGV
                     KNVYLIGGMNTLSTNIEKQLKSENMTFERISGNSRYETSLKLAERLDKEKSISDIVVV
                     NGEKGLADAVSVGSAAAQENMPIILSDPNNGIKVANSFISSKNIKKSYIIGGTYSVSS
                     SIEQSLPNVKRLSGNNRNETNAKVLEEFYKNTDLKNAYITKDGMKKQGDLIDSLAVGV
                     LAAKNSSPVVLVGNSLDSSQYDVLNTKSFDNIVQVGGNGNEDAVKDILDLQEETIYRV
                     KTADELDVALRKADANDIITFKPDDNKKITSSFSIETKKAITVELEGLYTQTITVNMP
                     NGELTNKGTLDGTVKIMDIKNGTFINEGDINDIDIYDPNGCKIENKSGGDIWVLTISS
                     SAKDVNIENKGDISKVTNNSTSVIIRNSGNIDTLSGINAPAISGNKPRVDDTDKDEKR
                     ASGIYPTSEPLSPARAGYISVKIFTKPEDTNYKIYYRVVSSRPSALYIGDRIDTSDWT
                     AVPSSVLPFTIKAENGYYIEAVEINSDTKKVSRWGKSDYIDDGFYLKSETAKGLSADI
                     DFDGDYVKLTATGADSGCTVYYRIVSKKPVSMNVGDKVTISDWDEITTNRVRIEANDV
                     KDKYIELVELDDSTNKVTRWGASDKVVE"
     gene            complement(13883..14278)
                     /locus_tag="KRO40_002817"
     CDS             complement(13883..14278)
                     /locus_tag="KRO40_002817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HBH2093630.1"
                     /translation="MILKKHRETILYLFFGAFTTLVNIVSYLFFTRVILFNFMVANAL
                     AWILAVLFAYVTNKFFVFESKRIELIFLFKEFLFFVSFRLLSGIIEMIIMYIMIDLFF
                     VNDITVKVFTNIIVIVLNYLFSKMIIFRK"
BASE COUNT         5843 a         1569 c         2732 g         4184 t
ORIGIN      
        1 aaaataaaga gaaaataaat ggaaaataat cacaatataa atataaaata taaaaatcat
       61 cagggggata tgaaaatgaa caaaaaaata ttatcattag gtctagcagt atcattaatc
      121 ttagtaaact tcaaaagtgt aaatgcatca tcagtagtag aaaaaatata cggtaaagat
      181 agatatgaaa cagcagcaaa gatagctgat aaacagactt atgaaacagt aattttagta
      241 aatacagaaa aatcacttgc agatggatta agtgcaagtg gattatcggg agctacaaaa
      301 gctccaatac tatttacaca acaaaataag ataccagcag acacaaatag atgtctaaaa
      361 aatatcaaaa aagcatatat aataggtaca gaagatacta taagtaaatc agtagaaaaa
      421 gaactagatt ctaaaaatat agaagtcaaa agaattggtg gagaagatag actaaaaaca
      481 agctatttaa tagctaaaga aatagcaact ataaaaaaag tggataaagt actattaact
      541 aatgcatata gtggagaagc agatgcaatg agtgtatcat cagtagctac tagagatgga
      601 gctccaatca tacttacaga tggaaagagt gtgccttttg atgtaaaaaa tattcaatca
      661 tattgtatag gttcagagga gataatgagt aatcctctag ttaaaaatac aaactcagta
      721 agaatagaag gaactgaccg atttgaaact aacaaaaacg taatagacta cttttttaat
      781 agtgcagatg gattctatgt atcagatgga taccaattag tagatgcaat agcagctgca
      841 ccacttacta aaaactctcc aatggtacta gtaaatgatg gaagcgataa aactgtatta
      901 gaaggagcta agaatataac ctctgtaggt gaaataaatg agaaggtaat acaacagtgt
      961 ataaatgctt caaattcaaa tgggcaaccc ccaacaatta cagttggaag tacagaggta
     1021 tataagggtg aaaagtttga cactggcaag ttaaatatag tagctaaaga taacacaggg
     1081 aaggtattac caatagaagt tgatgggttt atagatacaa atagagtagg tacatacata
     1141 ttgacattaa aagctacaga cgaatgggga aaaagcacag gaaaaagagt agaaataaaa
     1201 gtgttggatg acaaatctca tgattacaac agcccagaat ttaaaaaaat ggtatctact
     1261 gaaatgtata acttaatcaa ttcctataga aaagaaaaag gcaaagagcc tttgctagtg
     1321 tctagtaggc tagaaggtat ggcaaatgca tggtctaagt atatgatgga taaaaaagta
     1381 tttgcacatt atatagatgg aaaaaatgct ccacaagtat tttctgaatt tggaatgaga
     1441 agtgaggaaa atatagcata tatttatata gattctaaga acgttcaaac gacacaagat
     1501 gcaaaagact tggcaaaggc tatatttgag gtgtggaaga agtctccaga gtacaatgca
     1561 aacatgctta gtaatgagtt ttatagtact ggatttgggc tttatatatt atctgatggt
     1621 caagtgcatg ctactcagga gtttttaaat ggaaatgaag gtagcttgta aaaaattcca
     1681 taaatcttgt ttttttgtta atttactgat attataaaat gaaaatcaca tctaaagtac
     1741 tttttgtaat ctgttttgtt attgctttac aggctatggt attttaggtg ttttttgttt
     1801 tagtagttta tagattttga gggaatcact actgaggatg taatttatga ttagctgaat
     1861 tatataaaaa aattagtagg aggagtttga tgaaggtaaa taagagagta ttatcaatag
     1921 gattgacaat atcattaata atggcaggag caccaaatat caatgcactt tcgagcatag
     1981 aaaagataca ggggaaagat agatatgaga cttctgcatt gatagcagat aaacaaatat
     2041 atgatacaat catattagta aatactgata attctatagt agatggatta agtgcaagtg
     2101 gattatctgg agttgcaaaa gctcctataa tgttggtgca aagagataag ataccaacag
     2161 atgttgaaaa aagactaaag gatgttaaga atgcttatgt tataggtaca gaggatacaa
     2221 taggtaaatc tgtagaaaat caacttaaga ataaagggat tgaagttaaa agaattggtg
     2281 gggaagatag aataaagact agctatctta tagctaagga gatttcagct attaaaccag
     2341 taaatgatgg tgataaggtt tttcttgtaa atggatacac aggtgaggct gatgcaatga
     2401 gtgtatcttc tgtagctgct agagatggag ttcctgtgat acttactgat ggaaagagta
     2461 taccatttaa agttgatggc gttcagtgct attctcttgg gtcagaggag ataatgagta
     2521 atgaacttgt gagtaagact aattcagtta ggattgctgg taaggatagg tttgaaacta
     2581 ataagaaggt tatacaacgc ttttataaag gaacaaagaa gttttatgtt tctcaagggt
     2641 ataagttagt tgatgctgtg gctggttctc cgttggctaa ggacaaacct atagtacttg
     2701 ttaatgatgg aagtgataag agtgtgctta gaggtgctga tgaagttact tctttaggtg
     2761 gaatggataa gaaggttgtt gaccaatgta ttagttctgc atctgataaa aatacaatgc
     2821 ctacaattac tgctaatgat gtagagattt ctgtagggga taagtttgat aatagtatgt
     2881 tgaatatagt tgctactgat tattatggaa atgatttaaa ggcaaatatt aaaggaaatg
     2941 ttgatattaa caaggctgga acatatgttt taaatataag tgtagtggat aatttaggtc
     3001 agaagagtga gattagtgta aatgttaagg tagttgtaaa tgcgagtaca aaagactcta
     3061 atagttatga gtttaaggct atggtatcta atgagatgta tgatttagtt aattcatata
     3121 gaaaagaaaa aggcaagaag agtttaagag agttagactc tttagctgga atggcaaatg
     3181 catggtctaa atatatggaa gataagaagg tatttgccca tgagattgat ggtaaaaatg
     3241 cagctgaagt attttttggc tttggagcaa gaagtggtga aaatattgca tatctaccaa
     3301 tgaatgttaa atctgtttat acttctaaag atgcaaaaga aatggctgag tctatttttg
     3361 atttatggaa gaagtcttct aagtataatg aaaatatgtt aaaagaagaa ttttatagct
     3421 ttggatttgg tatgcatgtt tctagtaaag gagaagtgaa tgcgacaatg gaatttttaa
     3481 atagttagat tttatattaa tttacattgg aaaagatata gtaaatttgt aaaaataaat
     3541 atataaaatt aaaataactt ataaaattat aaaaaataat ttaaaaataa taaaaatgat
     3601 gaaaaaacaa ttaatttgtt ggaaaaaact tcaattaatt ttgcataaat tattgaattt
     3661 atattttata tagtctatca taagagtgtg agaaatattt ggattatatg aacatggaaa
     3721 tttaatgtac ataattaaag agatgtaatt aatataatgt tgggaggaat ttaagaaatg
     3781 aataagaaaa atttagcaat ggcaatggca gctgttactg ttgtaggttc tgctgctccg
     3841 atatttgctg atactactgt taaagaagaa ggatatacgg tagtacaaga caaatatgaa
     3901 aaattactta aagaattaaa ggcaaagata aaagatggaa ctattacatc agttggtgtt
     3961 gaatttgatg gaaaaccaat tactacatta gcaccaaagg cagatggtag tgataaagat
     4021 gcaatagcag aacagttaga aactcttact aaaaaccaac ttaaaggttt aggtgatgga
     4081 aaatatgtag attttaaaat tacttatggt gctaaagcag aagttccagc tgcttcatta
     4141 agtgcagatg atatacaaaa atatgcagat caaataaatg cttctgagaa aatattagtt
     4201 gaagtagcag caggatctga agcaggtata gcaaaatttg attctgttaa caataaagtt
     4261 atagcaggag atgctcctct taaagttaaa gatgcagtga aagcgactgt tactactaat
     4321 ggtagtaata aaaaagttct tacaatatca gctgcagctg gattatcagg attttcatat
     4381 ggaacactta aagacacagg tgcaagttta tctgatgttg atgcaataac tcttgacact
     4441 acaaatgcaa caataacaga aggtgatact aaagtattag attttgataa ttcatttaag
     4501 tttaacgaaa gtactaaaaa agttggtagt ttagttacac caaatacaac aaacactcca
     4561 gcagatcctg gtactaaaac tactgttaga gtgataaaag ctgttgaaaa aacaatagat
     4621 gtaagttcaa attcaactac aaaagctaaa gatttagcta aacaatatgt attcacagat
     4681 gttagtgata ctgatccaga aagtttaagt tatatgctta aaaacataaa tgatggaaaa
     4741 gttgctgtta aaaattctga tggagattat gaagtaacta tattcccaga aggaaaaaga
     4801 ttaaatactt tatctgcttc ttcagctaaa actattttag gagataaaga tactccagca
     4861 aaaatagttt taaaggcttc aacaacaaag aaattagcag actatataga tgatttaata
     4921 acttataaca atagttattc aaatgtacaa actgtagcag gtagtgatag aatagagact
     4981 gctatagagc taagccgtaa gtactataac tctactgaca aaaatgcttt atatggagat
     5041 cctgtaaata acgttgtatt agtaggttct caagctatag ttgatggatt agtagcatct
     5101 cctttagcag cagaaaaaga tgctccttta ttgttaagtt ctaaagataa attagattca
     5161 tcaacaagag ctgagataaa aagagttatg gacttaaatt cttcaacagg aataaaaaat
     5221 aataaagaag ttttcatagc aggtggagta aattctatat ctaaagacgt tgaaaatgaa
     5281 ctaaaagata tgggacttaa agtaactaga ttatcaggtg atgatagata tgaaacttca
     5341 ttagcgatag ctgatgaaat agatataaat gataaagctt atgtggtagg tggaacagga
     5401 ttagcagatg ctatgagtat tgctccagtt gcatctcaaa taaaagatgg tgaagctact
     5461 ccaatagtag ttgtagatgg aaaatctgac aagttatcta aagaagctga agatttctta
     5521 gatgatgcac aagtagatat aatcggtgga gaaaatagtg tttctgctaa aatggaagat
     5581 tatatagatg atgctactgg aaaatctcca gaaagaatta gtggtgctga tagacaagca
     5641 actaatgctg aagttataaa agaatacttt gataaagatg gagtttcaaa ttacttctta
     5701 gcaaaagatg gttcaactaa agaggatcag ttagttgatg cattagcagc agcagcagta
     5761 gctggaaact acggttctaa gcataatgaa gatggagata taactacaga tgcttctcct
     5821 gctccaatta ttttagcaac tgataattta tcagctgaac aacatgtagc tgtaagtaaa
     5881 actgctacta ctaatggtgc taagaactta gtacaagtag gtcaaggaat agctgattca
     5941 gttgttagca aattaaaaga tttattagat atgtaatata aattttatat attgaataaa
     6001 aaaggtttct cttttgagaa acctttttta ttttaaacat aaatttttat aaataaaaag
     6061 aggctaatta gcctcttttt aatgtgagaa acacttaaaa aataagatgt aattatttat
     6121 ttaagtatca ttattatact ataccttaaa ataaatgtct actattctat aattttaagg
     6181 tataatagta agtggaaaat aaataaggag gtaaattaaa tatgtcagtt ttagatgtaa
     6241 tattagacaa aacagatgaa ttagaaatta aaaaattaaa taatatagta gataaaatag
     6301 atgctttaga agataaaata caaatactag atgatgaagc attaaaaaat atgacgaatg
     6361 tatttaagga taagttaagt aaaggagaaa ccttagatga catattgcca gaagcatttg
     6421 ctgttgtaag agaagtatca aaaagaatat taggtatgcg tcaatataga gttcaattaa
     6481 ttggtgggat tgtattacat caagggaaaa tagcagagat gagaactgga gaaggaaaga
     6541 ctctagtagg agtagctcca gtttacttga atgcattgac tggtaagggg gtacatgtca
     6601 tcacggttaa tgattacttg gctcaacgtg ataaagaact tatgcaacca gtatatgaat
     6661 ttttaggttt aacagtagga gtaattatta atgggcaaca gccagtagaa cgaaaattac
     6721 aatatcaatg tgatattact tatggtacaa acaatgagta tggattcgat tatttaagag
     6781 ataatatggt aacgcaaaaa tcagagaaag ttcaaagaga actaaacttt gctatagttg
     6841 atgaggttga ttcaatactt atagatgaag ctagaacacc acttataatt gctggtggag
     6901 gagatgaagg tactaagctg tatgaacttg caaatgcttt tataaagaat ataagagatg
     6961 aagattttga aatggataga aaagataaaa ccatagcact tactgcaagt ggtcttagta
     7021 aagctgagaa attttttgga atagaaaata taactcatat agataatata gaaatttttc
     7081 accatgtaaa tcaatctcta agagcacata aattaatgaa catagatgtt gaatatgttg
     7141 ttagagataa tgagatacta attgtagatg aatttacagg aagaataatg gatggaagaa
     7201 ggtttactga tgggcttcat caagcaattg aagctaaaga gggagtaaaa ataaatgatg
     7261 aatcaaagac catggcaaca gtaacatttc aaaatttctt tagattatac tctaaattat
     7321 caggaatgac aggtacagca aagacagagg aaagtgagtt tgaagctaca tataagatta
     7381 atgttgttca gataccaact aataaaccag ttataagagc tgatttacat gataaagtat
     7441 tcaaaacaga acgtgcaaag tacaatgctg ttgtagaaga aataataagg ataaataaaa
     7501 ctaagcaacc agtgcttgta ggaactgttt caattgaaaa atctgagaaa ttatctaagc
     7561 tacttaaaaa gaaaggtgta aagcacgagg tcttaaatgc taaacaacat gataaggaag
     7621 ctgaaataat atctaaagct ggtaaattag gttctgttac aattgctact aatatggcag
     7681 gtagaggaac tgatatatca cttggagctg gagataaaga agaagaagaa aaggtgaaag
     7741 agttaggtgg cttgtatgtt ataggtactg aaagacatga gacaagaaga attgataatc
     7801 agcttagagg gcgttcggga agacaaggtg accctggaac ttctagattc tttgtaagtt
     7861 tagaggatga agtaataaaa ttgtatggtg gaaaaagtat agaaaaaata ttaaagagaa
     7921 tgaatgctaa tgaagatgac gcgttagaaa gtaaggcttt gaatagagca atagaaagag
     7981 cacagaaagg cattgaaggt aaaaattttg aacaaagaaa gaatgttctt aagtacgatg
     8041 atactattaa tgagcaaaga aaagtaatat atgatgaaag aaataaggta ttggatggtt
     8101 ctgatattga agaagagata caaaaaatgg ttatggatat tattacggag gctgctgaaa
     8161 agtacttaaa aaaatttaga gactatcatg gatattttaa gtatttatat aatactttta
     8221 tgccagctga tactttatta attccagact tagataaaaa aaatgttgaa gaaatagtaa
     8281 atcaaacata tcagatttca aagcgtgttt atgatcttaa gaagatgatg attggaattg
     8341 aagaattggc tcaattagag aaacgagtat tacttcaagt tgtggatact tattgggttg
     8401 accatataga tgcaatggat caactaagac aatatatagg tcttaaatct tatgcacaaa
     8461 aagatccatt taaagagtat gctatagaag gttatgaaat gtttgaagct ttaaatagga
     8521 atataagaat aacaacagtg caatatctat ataaatttaa ctaaaaaagt gacccattgg
     8581 gtcacttttt atatattaag attaaagtga aatttatttt acagtacaca ctcatataga
     8641 taaatattta taataatgaa aaagaggctg aacgtcagcc tcttttcctg tgtgagaaat
     8701 acggaaaaaa gagatgcttg aaatttcttt cttccattta atattatact ataaagagaa
     8761 taaaaagtcc atgagttatc tttatgatta aaaaaaaaaa ttacaatttt gttacttttt
     8821 agtatacaat aataaattta aattgacttt gttaattttt attaataaaa tatccaaata
     8881 ttacaatatc tacagtttat tgaaataatg tgtaaattat attataattg gtaaataagg
     8941 aaaaatggtg aaaaccaaat tttgtagggg gaaatatatg aatagaaaaa atctttatgt
     9001 aattatggca gctgcaatgg taagtacatc agtagctcca agttttgctg cagaagctac
     9061 acaagtaaag aaacaaacaa taactaaaaa ggaagcaaca gaattagttt ctaaagttag
     9121 agaactaatg gctcagagat atacaggagg ttctcaagtt ggacaaccaa tatatgaaat
     9181 aaaagttggt gaaacttcat cacaattaaa aataataact aatatagacg aattagagaa
     9241 attagtaaat gctttaggag aaaataaaga gcttcttgtg actatagcag ataaaggaca
     9301 tacaacaaat agtgcaaatg aagtggttgc tgaagcaatt gaaaaatatg aaaattcagc
     9361 agacctttca gctgaagcta attcaataac agaaaaagct aaaactgaag ctactgggat
     9421 ttatggagtg gcaactgtag aagcttcata tgacagtaca aaagataagt tagtaataac
     9481 tttaaaagat aagactgatg tagtaacttc taaaacgcta caaataggta ttggtgatga
     9541 aaaggttgat ttaacagcaa atccagttga tatagcagga accaatttag acccttctgc
     9601 agaaggattt agagtaagta aaataaataa attaggtgta gaaggagcta aaaatattgc
     9661 tgatattcaa ttagctgaaa taactataaa aaatagtgat ttaaatacag tttcacctca
     9721 agatttatat gatggatata gattgactat tcgaggtaat acaatagcaa atagtgtagg
     9781 aaaatcaatt agtgatattt catcaaaaga ttcagagaca ggaaagtata aatttactgt
     9841 taaatatact gatacatctg gaaaagcgat agaacttact gtagaaagta ctaatgataa
     9901 agagttaaaa gatgttaaag atgccttaaa tggaaataca aaagtcaatt taatagctgg
     9961 ggaagacagg tatgcaactg ctgtagctat agcaaaagaa acagaatata ctgacaatat
    10021 agttatagtt aattcaaata aattagttga tggattagca gcaacaccac tagctcaatc
    10081 taaaaaagct cctatattgt tggcgtctga taatgaaata ccaaaagtaa ctttagatta
    10141 tataaaggaa ataattaaaa aaagtccatc agctaaaata tatatagtag gtggagaatc
    10201 agcagtatca aatacagcta gaaagcaatt agaatcagta actaagaatg ttgaaagatt
    10261 ggctggagat gatagacata caacttcagt agcagtagca aaagctatgg gttcttttaa
    10321 agaagcattt gtagtaggtg caaaagggga agctgatgct atgagtatag ctgctaaagc
    10381 tgctgaactt aaggctccta taatagtaaa tggttggaat gatcttacag cagatgctat
    10441 caagttgatg gatggaaaag agattggtat agttggtggt tctaataatg tacctagcca
    10501 aattgaaaat caacttgctg atattgataa agatagaaag gttcaaagag ttgaaggtga
    10561 aacaagacac gatactaatg ctaaagttat agaaacatat tatggcaaat tagataaact
    10621 atatatagca aaagatggat atggaaataa tggtatgtta gtagatgcat tggcagcagg
    10681 tcctctagca gcaggaaaag gaccaattct tttagctaaa aatgatataa caaactcaca
    10741 aaagaatact ttagataaaa aactaaatct tggtgcagaa gtaactcaaa taggtaatgg
    10801 ggttgaattg actgtagttc aaaaaatagg caaaatacta ggatggtaat aatcaataat
    10861 atagaaaagg attccttatt atttatagga atctttttct atcgacataa tattcattaa
    10921 agtataacat gctcttgaca gataggagga tatgatagtg atagaagcaa cattgttttt
    10981 ttccccacac caagatgatg aaacattaag tatgggtagt gcaataattg aacatgtaga
    11041 aagaagcgat acacatgtta tattatgtac tgatggcagt aaatcaataa taagaaaagt
    11101 attagatgat ggagggtcat gttcttatca tattaaagat gtacacaagt actctttatc
    11161 agaaagtgat ttttcaaaaa atagagatga agaatttaaa aatagttgta aagcaatggg
    11221 agttaaagaa aataatatac atatagaaaa taatagagct catgatggag aattgagtaa
    11281 ggaaaaagca agagatataa tgctaaaata tttagaaaaa tatcctgatg ctaaagtgaa
    11341 gaccgttaca ccatataaag ctcttggaat acatgaagac catagagcat taggtgaagc
    11401 tgcattagaa ttgtatagag aaggaaaaat aaaagattta agattttatg tagagccata
    11461 cgattataat gattttaaaa aagttaatcc aaatgttaga gtatggaagg ttttgagtag
    11521 tcaagaagag aaattattaa atgctatgga tgcatacaag aaatggaatc ctgaaaatgg
    11581 taactacgca attggatatc attctgtaaa atctcacttt gatgaattaa aatccaataa
    11641 aatccaatat gtacatgctc cataaacatt aatataaaaa ctaggaggat atagttaatg
    11701 aaaatatcta agagaataat gtcgttgttg acagcaactt tttttatctt tgcattatct
    11761 atcaatatag ctgatgcttc atcaaaagag agtctagtgg gctctggtag atgggaaact
    11821 gcaataaaaa ttagtcagaa tggatggaaa gatgctacta atgctatact agtaaatgat
    11881 aattctatag ctgatgcatt atctgcaact ccatttgcta agttaaaaga tgcacctatt
    11941 ttattaactc aaagtgataa attggatagt agaactaaag cagaattaaa aagactaggt
    12001 gtaaaaaatg tatatttaat tggaggtatg aatactctaa gcaccaatat tgaaaaacaa
    12061 ttaaaatcag aaaatatgac ttttgagagg atttcaggta atagtagata tgaaacatct
    12121 ttaaaattag ctgaaagatt agataaagag aagagtattt ctgatatagt tgtagttaat
    12181 ggagagaaag ggctagcaga tgcagtaagt gtgggttctg ctgcagcaca agaaaatatg
    12241 ccaattatac tttcagatcc taacaatgga ataaaagttg caaatagctt tattagtagt
    12301 aaaaatataa agaaatctta tataattggt ggtacatatt ctgtatctag ttctattgaa
    12361 cagagtttac ctaatgtaaa aagattatct ggaaacaata gaaatgaaac taatgcaaag
    12421 gttctagaag aattttataa aaatacagac ttaaaaaatg cttatataac taaagatggt
    12481 atgaaaaaac agggggattt gatagattct ctagctgtag gtgtattggc agctaaaaat
    12541 agctctccag ttgtattagt aggaaattca cttgactcta gccaatatga tgtgttaaat
    12601 actaaaagtt ttgataatat tgtgcaagtt ggtggaaatg gaaatgaaga tgctgtaaag
    12661 gatattcttg atttacaaga agaaactata tatagagtta agacagcaga cgaattggat
    12721 gttgctctaa gaaaagcaga tgctaatgat attataacat ttaaacctga tgataataaa
    12781 aaaattacta gttcatttag tatagaaaca aagaaagcta taactgtaga gcttgaagga
    12841 ttgtatacac aaacaataac tgtaaatatg ccaaatggag aattaactaa taagggtaca
    12901 ttagatggaa ctgtgaaaat aatggatata aaaaatggca catttatcaa tgaaggtgat
    12961 ataaatgata ttgacattta tgatccaaat ggatgtaaaa tagagaataa aagtggtgga
    13021 gatatatggg ttttaactat atctagtagt gctaaagatg taaatataga aaataaaggt
    13081 gatataagta aggttacaaa taattctact agcgttataa taagaaattc aggaaatatt
    13141 gatactttaa gtggaattaa tgcaccagca ataagtggaa ataaacctag agttgatgat
    13201 accgataagg atgaaaaaag agcaagtgga atatatccta cttcagaacc tttatcacct
    13261 gcaagagctg gttatataag tgtaaaaata ttcactaagc ctgaagatac aaattataaa
    13321 atttattata gagtagtaag cagtagacca tctgcattat atatcggaga tagaatagat
    13381 acaagtgact ggactgctgt accatcttct gttttaccat ttactattaa agcagaaaat
    13441 ggatattata tagaagctgt tgaaataaat tctgatacta agaaagtatc tagatggggg
    13501 aaatctgact atatagatga tggattttat ttaaaatcag aaactgcaaa aggattaagt
    13561 gcagatatag attttgatgg agattatgtt aaattaacag caacaggtgc tgattctgga
    13621 tgtacagttt attatagaat agtatcaaaa aagccagtat caatgaatgt tggagataaa
    13681 gtaactatat ctgattggga tgaaattact actaatagag tgaggataga agcaaacgat
    13741 gtaaaggata aatatataga actagttgaa ttggatgatt caactaataa agtaactaga
    13801 tggggagcaa gtgataaggt agtagaatag gtatctaatg tgaaacataa aaacagactg
    13861 attaataatg ggcagtctgt ttttatttcc taaaaattat cattttacta aataaataat
    13921 ttaaaactat aacaattata ttagtaaata cttttacagt aatatcattt acaaaaaata
    13981 aatcaatcat tatatacata ataatcattt ctataatacc agaaagtagc ctaaaactga
    14041 caaaaaacaa aaactcctta aacaaaaata ttagttcaat tcttttactc tcaaacacaa
    14101 aaaacttatt agtaacataa gcaaataaaa cagcaagtat ccatgccaaa gcatttgcaa
    14161 ccataaaatt aaataaaata actctagtaa aaaataaata cgaaactata tttacaagag
    14221 tagtaaatgc tccaaaaaat aaatataata tcgtctctct atgctttttt aaaatcaaat
    14281 ataatcctcc taagctaatt taatataaat atacttaaag atactaac
//
LOCUS       DAEQCW010000095        14118 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.096, whole genome shotgun sequence.
ACCESSION   DAEQCW010000095 DAEQCW010000000
VERSION     DAEQCW010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14118)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14118)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14118
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.096"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..284)
                     /locus_tag="KRO40_002818"
     CDS             complement(<1..284)
                     /locus_tag="KRO40_002818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093631.1"
                     /translation="MNKVYIVTTYTGTILSYLIRNISKKLYTHVSISLNENLKPMYSF
                     GRLNPRNPFIGGFVEENINQGLYAIRKNTVCRVYSLEVDNLQYENLYKNI"
     gene            complement(443..1156)
                     /locus_tag="KRO40_002819"
     CDS             complement(443..1156)
                     /locus_tag="KRO40_002819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2140 domain-containing protein"
                     /protein_id="HBH2093632.1"
                     /translation="MGKVAKILLSLIVIVLVLVGIVVYILTPKERYDVSSQNNKIIDE
                     EYLSKGSYINSMEVVKNPLRMVGKISVSEEEFKNLIYTLMQKHGINELENNFVEMKNG
                     KIKVAGPYKVFGLVNSQYELELRPTLKDGNLVVSLENVKIGKFKLSDKMLEKILSNYN
                     KKVPFEVNGNKITLEKSYLYPITLKNISIKKGNVDLDMEVEIDLKSQINGALGYLKDS
                     GKVQDILNHLINLKKTSVG"
     gene            1448..3112
                     /locus_tag="KRO40_002820"
     CDS             1448..3112
                     /locus_tag="KRO40_002820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--tRNA ligase/YqeY domain fusion
                     protein"
                     /protein_id="HBH2093633.1"
                     /translation="MSNETNSSNFIKNIIINDLETGKHDSIITRFPPEPNGYLHIGHA
                     KSICLNFGLAKEFNGKANLRFDDTNPLKEDVEYVESIKEDVKWLGFDWNELNFASNYF
                     DEMYKRALILIKKGKAYVCDLTQEEMREYRGTLTEPGKESPHRNRTIEENLDLFERMK
                     NGEFKDGEKTLRAKIDMSSPNINLRDPIIYRISHSTHHNTGDKWCIYPMYAFAHPIED
                     AIEGITHSICTLEFEDQRPLYDWFVKECEMENIPRQIEFARLNINNTVMSKRKLKQLV
                     DEGIVDGWDDPRVPTISGIRRKGYTAEALRNFCSEIGVSKVNSTVDSQMLDYFLRENL
                     QPKAPLTMGVLRPLKLIITNYPEDKIEMLEIENNAKDESQGKRLVPFSRELYIEQDDF
                     MEEPVKKYFRFFPGNEVRLKGAYFVKCTDVIKDENGNVVEIHGTYDPETKSGSGFTGR
                     KVKSTIHWVDAKSAIPCEFRLFEPLILDDIPENEGKHFLEQINPNSLEILQGFVEPTQ
                     IKDAKPFDKFQFVRNGFFSIDNKYTTDEKFVFNRIVPLKSSFKPGK"
     gene            complement(3219..4118)
                     /locus_tag="KRO40_002821"
     CDS             complement(3219..4118)
                     /locus_tag="KRO40_002821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YegS/Rv2252/BmrU family lipid kinase"
                     /protein_id="HBH2093634.1"
                     /translation="MKKVKLIYNPNSGEKKILSNLDTIIELYQEKNYLLIPYRLTIKE
                     PVKNAFKEVDSSYEHILIAGGDGTVDLVVNAMKELDIKIPIGILPTGTANDFSNALQI
                     SFDIKEAINEIINSKPKKIDIGKVNNKYFINVASAGMFTDVSQRINTDLKNSFGRISY
                     YIKGIEEALYMRKFKIKVSSEEMYYDGDMYLMLIFNGKTAGNINLAYKAEIDDGYLDV
                     IIFKGMPIPKSIPVLISVLRGDYLDQYNGNEILYFKTKKVHIECEDSLITDIDGEKGP
                     DFPLNIECIKDGIEVMGICSEKS"
     gene            complement(4145..4783)
                     /locus_tag="KRO40_002822"
     CDS             complement(4145..4783)
                     /locus_tag="KRO40_002822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003356606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBH2093635.1"
                     /translation="MDQNLNWLNEKRIEKTIKSLENNNMKGYLVSNKEELLKKIEEIV
                     KAGSLVGCGGSMTLFETGVIDFIREKYNFLDRYAKDIKPEEMKEIYRKSFSADAYFTS
                     TNAITEDGELYNLDGNGNRVAAMIYGPDKVIVIAGVNKIVKDVDEAIKRTKTIAAPAN
                     CKRLSTNTGCKTTGICIDCSSPGRICCSYTLIKRQLTPERIHVIFLNEDFGY"
     gene            complement(5124..6122)
                     /locus_tag="KRO40_002823"
     CDS             complement(5124..6122)
                     /locus_tag="KRO40_002823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4003 domain-containing protein"
                     /protein_id="HBH2093636.1"
                     /translation="MEQSFINGKVNLLIENYKALNEVKGSWQMGLIQHSCALAFTLKN
                     KRISPRLVEERIELIKKNTGLFSNFRGYNMFYMATLLSFESNPESSFKMILDIYKELK
                     SEKFWGDTYLPLTASIVYENREKMDYLTCISKMKIIYDYMRKKHPFLTSSDDYCNIAL
                     IAIHSKNLDEDLEYIEKCYEFLNENGFYKGNDLQALSQILLFSDDRTMLKCKKTIELK
                     KAFKENDCKMNYYGYPIIGAISLLDYREDEIIEEIKNVSNKLKEEKGFGNWSLGKSNR
                     VMISSAIVASIYADLIRNENNIGSITNNIFLNIVVAIQIACVMAATSAAIASSSSN"
     gene            complement(6220..6795)
                     /locus_tag="KRO40_002824"
     CDS             complement(6220..6795)
                     /locus_tag="KRO40_002824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093637.1"
                     /translation="MKLKEALITCVVCSVCLTPLLVNGETKIDADHCKESIVNIDTIV
                     KSGKSFNSKYNQGMEDYKNSDEYKLKVQKEKLQNQLGIKIKKLVPITFEVSYYTSLNQ
                     ENGYGAITATGDDLEDGFVANNHLSFGTKIIVDGKLKTVMDRGSSKYFSNSNAIDVFV
                     PKWSNESESEYYDRVNNMGRHYKKGYIIVEE"
     gene            7111..7374
                     /locus_tag="KRO40_002825"
     CDS             7111..7374
                     /locus_tag="KRO40_002825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093638.1"
                     /translation="MIKNTKQITVEVNEILLQEMSKITNDENNILTDLINESIVNYIL
                     ENKKHNIENKDLEEVIKFYKKENTEKPKSAARAIAEAKTHTLY"
     gene            complement(7811..8188)
                     /locus_tag="KRO40_002826"
     CDS             complement(7811..8188)
                     /locus_tag="KRO40_002826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093639.1"
                     /translation="MTITKIPPAELKVMKFIWSSDFTVASKDVIEAMEKLYNWKQTTT
                     LTLLSRLVNKQFLSARKIDRHTHYTVLIGEEEYLHFETKTFLDNMHGSSIESFMKSLF
                     KKGVNEEELNSVEKWVKDIKKDE"
     gene            8529..9641
                     /locus_tag="KRO40_002827"
     CDS             8529..9641
                     /locus_tag="KRO40_002827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBH2093640.1"
                     /translation="MNAFIRKRNKNYVVYLEFEDEKTGKRKQKNMGTFDKKREASKRL
                     NEVKESLYNDGFLVPSEITVSEFLLDFLNKYSENISLATYNNYVSICKNYINPSIGKY
                     KIQDLHPVHIQNYIDKLSYKLNPQSIKIHINILKLAIKRAYRLKLIKENVMDSIEAPR
                     YKKFKNEIYDREQMIKLLDLAKNTEMELPINLAIGLGLRISEVLGLTWDNIDFEENTI
                     TVNKITSRINGSVILKEPKTESSVRKISSPKELMSLLKEYKIKQNKNLLKSSIRNNNN
                     LLFFNKKCEPIAEDVMSKKFKRFLEKNELPHIRFHDLRHSHVTLLINSKVPIKVISER
                     VGHSNISTTLSVYSHVLKEMDKEASDKISESLFNAN"
     gene            complement(9849..10325)
                     /locus_tag="KRO40_002828"
     CDS             complement(9849..10325)
                     /locus_tag="KRO40_002828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093641.1"
                     /translation="MVKKRLVAVVISLAMISVGNFSYAHSGGHNSSGGHHNKNKSELT
                     RYYCGGHSAHQHNKGFCPYASTKENSGVTISSVHNEKNHKNYFAEKGYNKGYEDGCKG
                     LYNLSVTEAKSDNLYEKEILKSSYEKGYLIGYNEYKAKKVDDVMKKMLDIPMLASI"
     gene            complement(10524..12149)
                     /locus_tag="KRO40_002829"
     CDS             complement(10524..12149)
                     /locus_tag="KRO40_002829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2093642.1"
                     /translation="MLQVTGVGLRFGDKELFKDVNLKFTKGNCYGIIGANGAGKSTFL
                     KILSGEIEPNTGSISITDKERMSVLKQDHFEYEEETVLNVVIRGHERLWNIMKEKDAL
                     YMKEDFNEEDGIKAAELEGEFAELDGWDAETNAEKILMGLGITKDMHYKQMKELVGGE
                     KVKVLLAQSLFGKPEILLMDEPTNHLDFKSINWLNNFIMDLEESIVIIVSHDRHFLNQ
                     ICTNIVDVDFGKIQMYVGNYDFWYESSQLALQLAKDQNKKTEEKIAQLKEFIARFSSN
                     ASKAKQATSRKKQLEKLEVEDIQPSRRRYPYVGFTPAREIGNEVLEVHNLTKTIDGVK
                     VLDNVSFRLDRDDKVVFMGDEIATTALFNIVMGELEPDSGEYKWGVTTSQDYLPKNHN
                     KFFDGVEYSLVDWLRQFSEEKSESFIRGFLGRMLFSGEEALKEAQVISGGEKVRCMLS
                     KLMLSNANVLVLDDPTNHLDLESITSVNKGLEKFPGVLLFTSHDHEFISTIANRIIEI
                     TPNGIMDRKMDFDEYLESKEIQDQLAKMYGKDK"
     gene            complement(12487..13506)
                     /locus_tag="KRO40_002830"
     CDS             complement(12487..13506)
                     /locus_tag="KRO40_002830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-binding protein"
                     /protein_id="HBH2093643.1"
                     /translation="MKLIKTIDAVGQVLCHDITQIIPGEFKGRKFKKGHIVKEEDIPV
                     LLSLGKDNLYVWEKSEGMVHENEGALFLKELTAGENLDFSEIKEGKIDFIAACDGLLK
                     IDVDALFDLNCVGEIMMATLHNNFIVNKGLKVAGTRVIPLVIDEKKLEDAKKVVGNRK
                     IVNVVPFKPKKVGIVTTGNEVFYSRIVDKFGPVIEEKVKGFGCEVIGQTICPDDKEII
                     KSAIKEFISQGAELICCTGGMSVDPDDVTPTAIKETGADLVTYGSPILPGAMFLLAYY
                     GEVPIMGIPGCAMYHKTTVFDIVLSRVLIDEKLDKYDIARYGHGGLCMNCDVCTYPAC
                     NFAKI"
     gene            complement(13503..14072)
                     /gene="mocA"
                     /locus_tag="KRO40_002831"
     CDS             complement(13503..14072)
                     /gene="mocA"
                     /locus_tag="KRO40_002831"
                     /EC_number="2.7.7.76"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor cytidylyltransferase"
                     /protein_id="HBH2093644.1"
                     /translation="MINAVIMASGFARRMGANKLLLNYKGCSIIEHVFREVSKIDFHQ
                     VVVVSQYEEVLLLCNKYGFEYIDNKNANIGQSESIKLGVLNSSKCDGYMFFVGDQPFI
                     DNLYIDKIINTFKLDRDFIVIPRYKDMCGNPVIFPYSKKEELLALKEDEKGKTILKNS
                     SKIKYVEVPKEMLFDIDTKMDYERIGGKL"
BASE COUNT         4906 a         2249 c         1472 g         5491 t
ORIGIN      
        1 tttatatttt tatatagatt ttcatattgt aaattatcta cttctaacga atatacccta
       61 cacacagtgt tttttcttat agcatataat ccttgattta tattttcttc aacaaatcct
      121 ccaataaatg gattccttgg atttagcctt ccaaaagaat acattggttt tagattttca
      181 tttaatgata ttgacacatg tgtatacagc tttttactta tattccttat taagtaagat
      241 aatatagttc ctgtatatgt tgttacaata tagactttat tcatcatttc cccccaatct
      301 agtaactaaa taatattata cacttacaat ttaatatcat aagatattct aacataataa
      361 atgtggtttt acaaattttg attttaaggt actttaatat tatataatat aataaaaata
      421 taaatataag ttttctatat ttttaaccaa cagatgtttt cttcaaatta atcagatgat
      481 ttagtatatc ttgaaccttt ccagagtcct ttaaatatcc taatgcccca tttatttgtg
      541 attttaaatc tatttctact tccatatcca aatcaacatt tccttttttt atagatatat
      601 ttttaagtgt tattggataa agataacttt tttccaaagt aatcttattt ccattaacct
      661 caaatggaac ttttttattg tagttactta atattttttc tagcatttta tcacttagtt
      721 taaattttcc aattttcaca ttctcaagac ttacaactaa gtttccatcc tttaaagtag
      781 gtctcaattc aagttcatat tgactattta ccaaaccaaa taccttatat ggtcctgcta
      841 cctttatttt accatttttc atttcaacaa aattattttc aagttcatta attccatgct
      901 tctgcatcaa tgtatatatt aaatttttaa actcttcctc tgaaacagat atttttccaa
      961 ccattctaag tggatttttt actacctcca tagaatttat atatgagcct tttgataaat
     1021 attcttcatc tatgatttta ttattttgtg aactaacatc atatctttct tttggtgtca
     1081 agatatatac aacaattcct acaagtacta aaacaataac aattaaactt aacaaaatct
     1141 ttgcaacctt tcccataatc gtctccttta caaatctgtc atcagattta aaataaattt
     1201 agataactaa cttcacataa tattcttaac aatatacata ctataataca gtcttttaaa
     1261 aattaattca accaatctaa tgttttgtaa ataaactgta aaaacatgtt tttagtataa
     1321 aagttaatat tttgcataat actcttaatt acacctttat ttttttctaa tcttggatta
     1381 aaattaatat tatgcaatac agtgtagtgt tctgtattat aatcaaatta aataggaggt
     1441 atagaatatg tcaaatgaaa cgaactcatc taactttata aagaatatta ttataaacga
     1501 cttagaaaca ggaaaacatg acagtatcat aactcgtttt ccacctgagc caaacggata
     1561 tttacatatt ggtcatgcaa aaagtatatg tcttaatttt ggattagcta aggagtttaa
     1621 tggaaaagct aatttaagat ttgatgatac aaacccatta aaagaggatg ttgaatatgt
     1681 agagtccata aaagaagatg taaagtggtt aggatttgat tggaacgagt taaattttgc
     1741 atctaactac tttgatgaaa tgtataagag agctttaata ctaataaaaa agggtaaagc
     1801 ttatgtatgt gatttgacac aagaggaaat gagagaatat cgtggtactc taactgaacc
     1861 aggaaaagaa agtcctcata gaaacagaac tattgaagaa aaccttgatt tatttgaaag
     1921 aatgaaaaat ggtgaattta aagatggtga aaaaacatta agagccaaaa tagatatgtc
     1981 ttctccaaat ataaacctta gagacccaat tatatataga atatctcatt caacacacca
     2041 taatacagga gataaatggt gcatatatcc tatgtatgct tttgctcatc caattgaaga
     2101 tgcaattgaa ggaataactc actctatatg tactttagag tttgaagacc aaagacctct
     2161 ttatgattgg tttgttaaag aatgtgagat ggaaaatata cctagacaaa tagaatttgc
     2221 tagacttaat ataaataata ctgtcatgag taaaaggaaa ttaaaacaac ttgtagatga
     2281 gggtattgtt gatggttggg atgaccctcg tgttcctaca atatccggaa tcagacgtaa
     2341 gggatatact gcagaagcat tgcgcaattt ctgtagtgaa ataggggtat caaaagttaa
     2401 ctctacggta gatagtcaaa tgcttgatta tttcctaaga gaaaacttac aaccaaaggc
     2461 tcctcttact atgggagttt taagaccttt aaaacttatt ataactaatt acccagaaga
     2521 taagattgag atgcttgaaa tagagaataa tgctaaagat gaatctcaag gaaagagatt
     2581 agttcctttc tctagagaat tgtatataga acaagatgat tttatggaag aacctgttaa
     2641 gaaatatttt agatttttcc caggaaatga agtccgttta aaaggtgctt attttgtaaa
     2701 atgtactgat gtaattaagg atgaaaatgg aaatgtagtt gaaatacatg gtacttatga
     2761 ccctgaaact aagagtggct ctggctttac aggacgtaag gtaaaatcta caatacattg
     2821 ggttgatgct aaatcagcta tcccatgtga atttagatta tttgaaccat taattcttga
     2881 tgatatacct gaaaatgaag gtaaacattt cttagaacaa ataaatccta attcattgga
     2941 aatattacaa ggttttgttg aacctacaca gataaaagat gctaaacctt ttgataaatt
     3001 ccaatttgtt agaaatggat tctttagtat agataataaa tatacaactg atgaaaaatt
     3061 tgtatttaat agaatagttc ctctaaaaag ttcttttaaa ccaggtaaat aatcttacaa
     3121 tcaaaaaatg aagacttaaa atataaatta cttctactat aaataaactt agttagaagt
     3181 aattttttat ttgagtcttc atcatttact ttaaatgatt aacttttttc actacagatt
     3241 cccatgactt ctattccatc ttttatgcat tctatgttaa gaggaaaatc tggtcctttt
     3301 tctccgtcaa tatctgttat aagtgaatct tcacattcta tatgcacctt tttagtttta
     3361 aagtatagta tttcatttcc attatattga tctaaataat cacctctaag cacacttatc
     3421 aaaactggta ttgattttgg tattggcatt cctttaaaaa taattacatc caaatatcca
     3481 tcatctattt cagccttata tgctagattt atatttcctg ctgttttgcc attaaaaatc
     3541 aacataagat acatatctcc atcataatac atttcctcag aagatacttt tatcttaaat
     3601 ttcctcatat acaatgcttc ttctattccc tttatataat aagaaattct tccaaatgaa
     3661 ttttttaagt ctgtgtttat cctttgtgat acatccgtaa acataccagc acttgcaaca
     3721 tttataaagt acttattatt gactttccct atgtctattt tctttggttt tgaatttatg
     3781 atttcattta tagcttcttt tatatcaaat gaaatttgaa gagcatttga aaaatcattt
     3841 gcagttcctg taggcaaaat tccaattgga atttttatgt ctaattcttt cattgcattt
     3901 actactaaat ctacagtacc atcaccacca gctatcaata tgtgttcata agaactatca
     3961 acttccttaa atgcattctt tacaggttct ttaatagtta atctataggg tatcaataaa
     4021 taattttttt cttgatataa ttctatgata gtgtctaaat ttgataatat ctttttttca
     4081 cctgaattag gattgtatat aagttttact tttttcatta tttctcctta ctcattttat
     4141 tcttttagta tccaaaatct tcatttaaaa aaatcacatg tattctttct ggtgttaatt
     4201 gtctttttat aagtgtataa ctacagcata ttcttcctgg acttgaacag tctatacata
     4261 taccagtagt cttacatcca gtatttgtac ttaatctttt acaattggct ggagcagcta
     4321 ttgtttttgt tctttttata gcttcatcta catctttaac tattttattt actcctgcta
     4381 taactattac tttatcaggt ccatatatca tagcagcaac cctattccca ttcccatcta
     4441 aattgtaaag ttctccatcc tctgttatcg cattagtact tgtaaaataa gcatctgcag
     4501 aaaatgactt tctatatatt tctttcattt cttctggttt gatatctttt gcatatctat
     4561 caagaaaatt atatttttct cttataaaat caatcactcc tgtttcaaat aaggtcatag
     4621 aacctccaca tcctactaga gaacctgctt taactatttc ttcaattttt ttaagaagct
     4681 cttctttgtt acttactaaa taccctttca tattattgtt ttccaaagat tttattgttt
     4741 tttctattct tttttcatta agccaattta aattttgatc cattttaact tcccccttat
     4801 ttttaatatg tacttaatta tttataaact ttattttctt tataagttta ttttagtaca
     4861 tctaaaaaaa aatacaatat aaaacttaaa tagttttaca taattttttc caaaataact
     4921 tactcaatca aaaaaggaaa gtagatgtac tattctactt tccctatatt gtatgtagta
     4981 ttatatattg cctaaaatct atatattaat tatatgtttc atattatatg aatatcacag
     5041 ttaattaaaa tgtaatacta tcttcttttt aaacatataa attgtattat taaatttaat
     5101 atatccaact tcaataaatc ttattaattt gatgaagaag atgctatagc tgcacttgtt
     5161 gctgccatta cacatgcaat ttgaatagca acaacaatat ttaaaaatat attattagtt
     5221 atagagccta tattattctc atttcgtatc aaatctgcat aaattgaagc tacaatagca
     5281 gaactaatca ttactctatt actttttcct aaagaccaat ttccaaagcc tttttcttct
     5341 ttaagtttat ttgaaacatt ttttatctct tctattattt catcttctct ataatctaat
     5401 aatgaaattg ctcctattat tggatatcca taataattca ttttacaatc attttcttta
     5461 aatgcttttt taagttcaat agtcttttta catttgagca tagttctatc atcactaaat
     5521 aaaagaattt gggataatgc ttgtaaatca tttcctttat aaaaaccatt ttcatttaga
     5581 aattcataac atttttctat gtattctaaa tcttcatcta aattttttga atgaattgca
     5641 ataagtgcta tattacaata gtcatcacta gaagttagaa atggatgttt tttcctcatg
     5701 taatcatata ttattttcat ttttgatata catgtaagat aatccatttt ctctctattt
     5761 tcataaacta ttgatgctgt aagtggtaaa tatgtatcgc cccaaaactt ttcactttta
     5821 agttctttgt atatatctaa aatcatctta aaactacttt ctggatttga ttcaaacgaa
     5881 agtagtgttg ccatataaaa catattatat cctctaaaat tagagaataa tccagtattt
     5941 tttttaataa gctctattcg ttcttccact aatctaggac ttattctctt gttcttaagg
     6001 gtaaatgcaa gtgcacaact atgttgtatc aatcccattt gccaagaacc tttaacttca
     6061 tttaatgctt tgtaattttc tattaataag tttacttttc catttataaa cgattgttcc
     6121 atattgccct cctagtaata tatctcattg tactaatagt tttatattta ttatatatat
     6181 attaaatact acaatcaata catattactt caaagaacat cattcttcaa caataatgta
     6241 gccttttttg taatgtcttc ccatattatt gactctatca tagtactctg attcactttc
     6301 attactccat ttgggcacaa atacatctat tgcattagaa ttactaaaat atttactaga
     6361 ccccctatcc ataacagttt ttaattttcc atctacaata atcttagttc caaaacttaa
     6421 gtgattgttt gctacaaaac catcttctaa atcatctcct gtagcagtta tcgctccata
     6481 tccattttct tgattaagac ttgtgtaata actaacttca aaagttatag gtactaactt
     6541 ctttatttta atacctaact gattttgtag tttctccttt tgtactttca acttatactc
     6601 atcactattt ttataatctt ccataccttg attatacttg gaattaaagc ttttacctga
     6661 ctttactata gtatctatat ttactataga ttctttacaa tgatctgcat ctatttttgt
     6721 ttctccattt accaataatg gagttaaaca tacactacat acaacacatg taatcaatgc
     6781 ttctttaagc ttcataaatt ccccccttat tattttgata tattagcata tttaatatta
     6841 tatgtctaca tttagattta aataccacac ccatttgctt taagaagttg tcttatattt
     6901 aattcacctt aaacacttat aaatcctcta tcttagaatc atatagaata aagcttttat
     6961 ctttaaatat tttttattaa tcttttaaaa tctaaaacta ctttatctaa ttttctcttt
     7021 tttagaattt aagaattaaa attctataat tttaaaacat attgaattta tttttttgag
     7081 atgatataat tttcttaaga ggtggttgat atgataaaaa atacaaaaca aattacagta
     7141 gaagttaatg aaattttatt acaagaaatg tctaagataa ctaatgacga aaataatatt
     7201 ttgacagatt tgataaatga atcaattgta aattatattc ttgaaaacaa aaaacataat
     7261 attgaaaata aagatttaga agaagtgatt aaattttaca aaaaagaaaa tactgaaaaa
     7321 cctaaaagtg cagcaagagc tatagctgaa gcaaaaactc atactctgta ttaatcaaat
     7381 aaaaaagttc ctaaaaacta ggaacttttt tatattaata attattaata tatctcaata
     7441 tttatctcaa atctatcaat ataagcatgt ttaatacaat ctattgtata cttatcttac
     7501 cctagaaata atcaaaacaa aaataaaatt atgcccttta tatctaaaac aattaattta
     7561 catgattaat atacaaaaat tctgactttt aaattcgtat acaatatcaa actaaaataa
     7621 tattaatgac aaacccaata taaattaaat tcaaacaggt ttgattttac atcaaactta
     7681 ttgtattaat attaaataac aagacaaaaa tatttataaa aatcacaaat tttacataaa
     7741 actttatatt tgattcattt aactaattat tgtaaaaact atttatttta tgataattaa
     7801 ctacaccaaa ttattcatct tttttaatat ccttaaccca tttttcaaca gagttcaatt
     7861 cttcttcatt tacccccttt ttgaacaagg atttcataaa actctcaata gaacttccat
     7921 gcatattatc taaaaaagtt tttgtttcaa aatgtaaata ctcttcttct ccaataagaa
     7981 ctgtataatg tgtatgtcta tcaatttttc ttgcacttaa gaattgctta tttactaatc
     8041 ttgataaaag tgttagtgtt gtagtttgct tccaattata tagtttttcc atagcttcaa
     8101 tgacatcttt tgatgctact gtaaaatctg aactccaaat aaatttcatg acttttaatt
     8161 ctgctggtgg tatcttagta atagtcatat gattttacac tcctctcaaa cttctacata
     8221 attaaatact atattaatag acttttcgag tcaaaggttt tatttaaaat atctcatcca
     8281 aatttattaa tacaaaaaat ttatattttt attcaaaatt aaacacacaa tctattaata
     8341 taaagataaa tatctattct ataagtataa cagattatca aattaaaatt ctaatatttg
     8401 acataatata tacatttttt aaataaatat atacaatgta ttaaaatgta tgcaactcta
     8461 tttcaaaatt attttgtgat atatatatgt tataataaat gtataaaatt ttgattggtg
     8521 ggttatatat gaatgcattt attagaaaaa gaaataaaaa ctatgttgtt tacctggaat
     8581 ttgaagatga aaagacaggt aaaagaaaac aaaaaaatat gggtactttt gataaaaaaa
     8641 gggaagcaag taaaagacta aatgaggtaa aagaaagctt atataatgat ggttttttag
     8701 taccaagcga aattacagtg tcagaatttc tattagattt tctaaataaa tatagtgaaa
     8761 atatatcttt agctacatat aataattatg ttagtatttg taagaattac attaatccat
     8821 ctattggaaa atataaaata caagacttac atccggttca catacaaaac tacatagata
     8881 aactatctta taaactaaat cctcaatcaa ttaagattca tataaatata ttgaaacttg
     8941 caataaaaag agcttataga ctcaaattaa taaaagaaaa tgttatggat agtatagagg
     9001 ctccaagata taaaaaattt aaaaatgaga tttatgatag agaacaaatg ataaaattat
     9061 tagatttagc aaaaaataca gaaatggaat tacctattaa tttggctatt ggattaggtc
     9121 ttagaatttc agaagtttta ggtctaactt gggataatat tgattttgaa gaaaatacaa
     9181 taacagtaaa taagataact tcccgaatta atggttctgt tattctcaaa gagccaaaga
     9241 cagaaagctc tgttagaaaa atatcttctc ccaaagaatt aatgtcttta ttaaaagaat
     9301 ataaaataaa acagaataaa aatttattaa aatcttccat tagaaataat aataatttgt
     9361 tgtttttcaa taagaaatgt gaacctattg ctgaagatgt tatgagtaaa aaatttaaaa
     9421 gatttttaga aaagaatgaa ttacctcata ttagattcca tgatttaaga cactcacatg
     9481 ttactttact tataaattct aaagtaccta taaaggttat atccgagaga gtaggacact
     9541 caaatataag tactactcta agcgtttatt ctcatgtact taaagaaatg gataaagagg
     9601 cttctgacaa aatttctgaa agtttattta atgctaatta atattaattt atcttagctt
     9661 taaattagct tagcttattg agatagattc attaatatta aatgtatcta tctcaaatta
     9721 ataactactt aaataatctg ttttatttta atttatcgcc tcagttatta tactttttta
     9781 cgaaaaatta tactttacaa taaaaaagat attcccttat agaaaatatc tttttaaata
     9841 ctatattatt atatacttgc taacattgga atatctaaca tcttcttcat tacatcatct
     9901 actttttttg ctttatattc attgtatcca attaaatatc ctttttcata tgaacttttt
     9961 aaaatctctt tttcatataa attatcagat ttggcttctg tgacacttaa attataaagc
    10021 cctttacacc catcttcata acctttatta tacccttttt ctgcaaaata gtttttatga
    10081 tttttttcgt tatgtactga agatattgtt actccagaat tttcttttgt actagcataa
    10141 ggacaaaaac ctttattgtg ttgatgtgct gaatgtcctc cacaataata acgtgttaac
    10201 tctgatttat ttttattatg atgacctcct gatgaattat gccctcctga gtgagcatat
    10261 gaaaaattcc ctacactaat catagctaaa ctaattacta cagctactaa ccttttctta
    10321 accataatct attcccccca aaatgttata tatttttatt atatcatcta ctatattata
    10381 tttaaattct taatatacaa aatattactc tattctgcta ataaacatgt ttaaacaaca
    10441 taaaaaacct cctaatattt gattaaaaat ttacacactc atgcatagca tgtctcaaat
    10501 attaaaaggt tttatactaa taattattta tcttttccat acattttagc taattggtct
    10561 tgtatctctt tactttctaa atactcatca aagtccattt ttctatccat tattccattt
    10621 ggagttatct ctataattct atttgctata gtagatataa attcatggtc atgagaagta
    10681 aataaaagca ctcctgggaa cttttcaagt cctttattta cagaagttat actttctagg
    10741 tctaagtggt tagtagggtc atctaataca agtacatttg catttgaaag cattagctta
    10801 ctaagcatac atctaacctt ttctcctcca gatataactt gagcttcttt taatgcttct
    10861 tcacctgaga ataacattct acctaaaaat cctcttataa aactttcact tttttcttca
    10921 gagaactgtc taagccagtc aaccaaagaa tattctactc cgtcaaaaaa cttattatga
    10981 ttttttggaa gataatcttg agaagtagtt actccccatt tatactctcc actgtctggt
    11041 tcaagttctc ccataactat gttgaaaagt gcagtagtag ctatttcatc tcccataaat
    11101 actactttat catctctatc caatctaaat gacacattat caagaacctt aaccccatct
    11161 atagttttag ttaaattgtg tacttctaaa acttcattcc caatttctct tgcaggtgta
    11221 aatcctacat atggatatct tcttcttgat ggttgtatat cttcaacttc taatttctct
    11281 aactgtttct ttcttgatgt tgcttgttta gcctttgaag cattagaact aaatctagct
    11341 ataaattcct ttaattgagc tatcttttct tcagtctttt tattttggtc cttagccaat
    11401 tgtaaagcca attgacttga ctcataccag aaatcatagt ttccaacgta catttgtatt
    11461 ttaccaaaat ctacgtcaac tatattagta catatttgat ttaggaaatg tctatcatgt
    11521 gatactatta taactataga ttcttctaaa tccattataa aattatttaa ccagtttatt
    11581 gatttaaaat ctaagtggtt tgtaggttcg tccattaata gtatttcagg cttaccaaaa
    11641 agtgattgtg ctaacaatac cttaaccttt tccccaccaa ctagttcctt catttgtttg
    11701 taatgcatat ctttcgttat gccaaggccc ataagtattt tctcagcatt agtttctgca
    11761 tcccatccgt caagctctgc aaactcacct tcaagttcgg cagcttttat cccatcttct
    11821 tcattaaagt cttccttcat atacaatgca tctttttctt tcattatgtt ccaaagtctc
    11881 tcatgacctc ttataacaac atttaaaaca gtttcttctt catattcaaa gtggtcctgt
    11941 tttaaaactg acattctttc tttatcagtt atagatatac tacctgtatt aggctctatt
    12001 tctcctgata atatttttaa aaaagtagat tttcccgcac cattagctcc tattattcca
    12061 tagcaattac ctttagtgaa ttttaagtta acatctttaa atagttcctt atcaccaaat
    12121 ctaagtccaa cacctgtaac ttgtaacatt aatatatttt cctttctttt tgctcataat
    12181 ttattttatc ataaaacttt gataacattt ttattatata ttatcacgta aatagtatat
    12241 tttttatact aaatttgtga aatatttatt aaaataatac taaaaattgt aaatttataa
    12301 aaattaacaa tctcttatat tatacttata aagaaatcaa attgcaactt tattcattct
    12361 tttacacatt gaaaataagt tattataatt tctaaataaa tatgcttttc ttaaaacatc
    12421 attctagctg ttttgtttca tatttaaaaa gagtacttaa tttgtaaata ctctttttta
    12481 ataactttat attttagcaa aattacatgc aggataagta catacatcac agttcataca
    12541 aaggccacca tgaccatatc tagctatatc atacttatca agcttttcat caattaaaac
    12601 cctagataaa actatatcaa atactgtagt tttgtgatac attgcgcatc ctggtatacc
    12661 cataattgga acttctccat aataagcaag taaaaacata gctcctggta atattggtga
    12721 accatatgtc actaaatcag ctccagtttc ttttatagct gttggtgtaa catcatctgg
    12781 gtctacactc atcccaccag tacaacagat aagttctgct ccttgactta taaattcttt
    12841 tattgcactc tttataatct ctttatcatc tgggcatata gtctgtccta taacttcaca
    12901 accaaagcct tttacttttt cttctattac gggtccaaat ttatcaacaa ttctgctata
    12961 aaacacttca tttcctgtag taacaattcc tactttctta ggtttaaaag gtactacatt
    13021 tactattttt ctattaccaa ctactttttt tgcatcttct aattttttct catctataac
    13081 caaaggtatc actcttgttc cagctacttt taaaccttta tttactataa aattattatg
    13141 aagagtagcc atcattattt ctccaacaca attcaaatca aaaagtgcat caacatctat
    13201 ctttaataga ccatcacatg ctgctataaa atctattttc ccttctttta tttcactaaa
    13261 atctaaattt tctccagcag ttagttcttt taaaaacaat gcgccttcat tttcatgaac
    13321 cattccttct gacttttccc atacatacaa attatcttta ccaagagata ataacactgg
    13381 aatatcttct tcttttacta tgtggccttt tttaaatttt cttcctttaa attctccagg
    13441 tattatttga gttatgtcgt gacataaaac ttgtccaaca gcatctatag tttttattag
    13501 cttcataatt tacccccaat tctctcatag tccatttttg tatcgatatc aaataacatt
    13561 tctttaggaa cttctacata ctttattttt gatgaatttt ttaaaatggt tttacctttt
    13621 tcatcttctt taagtgccaa caattcttct ttcttgctat atgggaatat gactggattt
    13681 ccacacatat ctttgtatct tggaattact ataaaatctc tatctaattt aaaagtattt
    13741 ataattttat ctatatataa gttatcaata aatggctggt ctcctacaaa gaacatataa
    13801 ccatcacatt ttgagctatt taaaactcct aattttatag attcactttg acctatattt
    13861 gcatttttat tatctatata ttcaaaacca tatttattac acaataacaa aacctcttca
    13921 tattgactta ctactacaac ttgatgaaaa tcaatcttgc taacttctct aaatacatgt
    13981 tctattatag aacagccttt ataatttaat aaaagtttat ttgctcccat tcttctggca
    14041 aagcctgatg ccattatcac tgcatttatc atatatatca tccttggtat ttataatata
    14101 ttgatagttc tatgattt
//
LOCUS       DAEQCW010000096        13960 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.097, whole genome shotgun sequence.
ACCESSION   DAEQCW010000096 DAEQCW010000000
VERSION     DAEQCW010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13960)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13960)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13960
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.097"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            189..3737
                     /locus_tag="KRO40_002832"
     CDS             189..3737
                     /locus_tag="KRO40_002832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2093645.1"
                     /translation="MMNRLKPRILGISILFIIIIILTCGAVFKFKFKLDNKLKETTHT
                     YLSEFTEHNIINLKTRLSGQFDMLESIANFIGNLNNINDEMVIDLMDSDVKRSSLIRM
                     TISTLDGECYSNDGITHNVQDRDYFKKAKNGEKNISEPLKSIVNNKEIIVLSTPVYKS
                     GKIVGVLSGIYDSKKLNELLGLSAFDEKADVFVAKKNGDIVAQKTNKNRKTLSCIFQL
                     FDKDNCDEDDCLKTIKENMKNDKSGYFNYNLDNEKFMLNYQPLGVNDWYVFSVVPNKI
                     VSIQSENISYDVYIFALEILLVILIFIIYIACIINNNTKIIINEKEKFKVLTDNILGG
                     VKTCLKDEYMTMTYVSQGFLELTGYSCEDLNKIFKNRFKDMIYKDDLDKFNCIILNQL
                     EKQDKIEVEYRIVRKDGSIIWILERSKSINDNKGSECIQGVLTDITELKKIQEELDSK
                     RFEIQAINDSIVGGIVITEINDDFDSIYLNEGYLNMIGYTRKQLEDELNNKLIKLIFK
                     DDRTELINSINKQLKLSDTFASEQRVEKRDGTIIWILLKGRKMIYDNGKSVLCCVIVD
                     ITSAKLLEQELKKSEERHEIILKQTQNIIIEWDIEKDKMNISPNWYNKFKYDPITENA
                     TKNIIKSVDIYHDDMDKFISLIKLTSQGSEYEECEIRLRTRDTIYAWFSIKATTLFDN
                     NGKPYKVVGSLTDIDESKREAEKLKERAEKDPLTDLYNKKASQSLIEEYITLDKKRKG
                     ALMIIDIDDFKGINDNLGHLYGDAVLSEIANDLINLFRATDIVGRIGGDEFIVFIKDI
                     SETRDIINKAEELVKTFERSFLGKGRNYKISLSVGIAKFPQDGMDYMTLFRNADIALY
                     SAKGKGKNCYTLYDKKFDKVQYITNTRNAGDSDNVEMSFKEHITNYIFDILYESSDIE
                     VAVNLILSIVGKHFNVSRMYIFENSDDNRVCKNTFEWCNEGVTSEINNLKNICYKDLG
                     NYLLNFNADGLFYCNDIENLGSDVKKVLKPQGIRSILQCKILEGNEFRGFIGFDECSY
                     NRMWTNDEVNTLTFISKTLSMFLLKMRIQSKLEESLTIQKSVMDNMDIWAYVVDRNTY
                     ELLFINKKMLESAPNTHVGDLCYKAIWNNQDKPCKKCPMIYLKDGDDTYKSFMHNKKF
                     EVQANITTTTLKWFDGKDACLIFGSEITSIEAEENT"
     gene            3922..5856
                     /locus_tag="KRO40_002833"
     CDS             3922..5856
                     /locus_tag="KRO40_002833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgiQ family radical SAM protein"
                     /protein_id="HBH2093646.1"
                     /translation="MENKFLPISKQDMIDRGWEELDFVLVTGDAYVDHHSFGTAIISR
                     VLESAGYKVGIIAQPDWRTTDDFMKLGKPRLAFLVNAGNMDSMVNHYSVSKKHREKDM
                     YSPGGKMGYRPDRATIVYCNKIREAYSDVAIVIGGIEASLRRFAHYDYWSDKVRKSML
                     IDSGADLLVYGMSEKQIVEVANALNDGYDPKYIRHIDGTCYISDTLEEIYDKYILIPS
                     YKEICEDKMKYVEAFKIQYDEQDPFRGNIIVQPHGSKYLVQNKPEKPLSREELDEVYG
                     LPYQKTYHPVYEKFGGIPAIEEVKFSIVSSRGCFGSCSFCAITFHQGRAVQSRSEKSI
                     IDEAIGITNLDDFKGYIHDVGGPTANFRRPACKKQITKGACKNRQCLSPSPCKNLDAD
                     HSEYLHLLRAVRKLPKIKKVFVRSGIRYDYVMADKNNKFLRELIEHHVSGQLKVAPEH
                     ISEEVLKYMQKPAGKTYDKFRQKFFAINEELGKKQYLIPYLMSSHPGSTLNSAIELAE
                     YLRDTHYQPEQVQDFYPTPGTLSTTMFYTGIDPLTMKPVYVPKSKRDKAMQRALLQYR
                     APRNYDLVYSALVEAGREDLIGFGHRCLIKPKNEKPYFNRNNSKKNVSKGTNKNKKTN
                     TNNRSNKNQQKSSTKKKKKH"
     gene            5962..6957
                     /locus_tag="KRO40_002834"
     CDS             5962..6957
                     /locus_tag="KRO40_002834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2093647.1"
                     /translation="MKKYISIILLVVLTMVVLVGCSPGKDNPKNKELSVVKQVKVAVP
                     DGLPAVAIAKLANENPEIKEGYETVYSIEKTPEAISTRVMKKDADIAIVPSNMAAIAY
                     NKTSSYNIVGTVGMGSLYLVSTENIKDYSDLVGKEVGCTGKGLTPDITIKSLLLQKDI
                     NYSDIKFNYVNSASELVPLLATGKVKTGIVPEPALSALMSKNPDIKIIKSLNDSWKEV
                     SGSKDGYPQSTLIVKSEFLRDNKDFVDSFVGQLSNSIDWANKNPEELGAYSEKIKIST
                     ESKIIGKSLERANLKYIPVKDMIKDYKNYYEKLANFDDKTLGGKVPDEAIYFVEK"
     gene            6985..7713
                     /locus_tag="KRO40_002835"
     CDS             6985..7713
                     /locus_tag="KRO40_002835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH2093648.1"
                     /translation="MEVTLSCVILLFLWQIIALKIDNDIFLPTVGQVFNSIKEIMLNS
                     SFYIDILYSMGRCFFSFLLAMIFAIILSIVSYLNRFFRNLLKPINALTRSIPTMILVV
                     LALIWFEKDSTPFIVGFTIVFPILYDNVLGAILNIDKNLLEMANVYKIRFIDKVLKIY
                     LPAIKFQIISILVSTFSLSLKVAIAGEVYSQPTYGIGTMIQTEKINFNTSGIFAWIII
                     VLLISAILQIAQKFLARRAFLWKR"
     gene            7701..8399
                     /locus_tag="KRO40_002836"
     CDS             7701..8399
                     /locus_tag="KRO40_002836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093649.1"
                     /translation="MEKIKLSIENINKRYDSRIIFRDFNIDFYVNEVNCILGKSGCGK
                     TTLLNIISGIIKNDTNNLNIKENLNRVGNKLEASYIFQDDRLIDWLTVEENIKIVVNK
                     YYNKTQLNKICDEYLELVGISDYKKFYPQMLSGGIRQRVNIARAFIYPSKNIIMDEPF
                     KSIDAKNTQLIMDNFRNILRKEKRTVLFVTHNIEEALFLADRIFILGDSPIRIKKILK
                     NSKELEKNEVLKLI"
     gene            8522..8995
                     /gene="ybaK"
                     /locus_tag="KRO40_002837"
     CDS             8522..8995
                     /gene="ybaK"
                     /locus_tag="KRO40_002837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-tRNA(Pro) deacylase"
                     /protein_id="HBH2093650.1"
                     /translation="MVKTNAMRILDSNKIDYKVMSYEVKSEHVDGVEVAHDIGRDVNE
                     VYKTLVTQGVSKNIYVYVIPVHENLDLKKAAKVAKEKSVEMIHVKDINKLTGYIRGGC
                     SPIGMKKLYKTFVNESAKNLDTIIVSAGKIGYQIELSPFDLQRLIKVEFVDVIKK"
     gene            9192..10031
                     /locus_tag="KRO40_002838"
     CDS             9192..10031
                     /locus_tag="KRO40_002838"
                     /EC_number="4.2.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarate hydratase"
                     /protein_id="HBH2093651.1"
                     /translation="MRKIKSEQIVEQVKKLCIEASLYLGEDVLSCIKEKAKSEKSEVG
                     KNILNILVENAEIAKEKNIPICQDTGMAVFFVEIGQEVLIEGDTLTDAINEGVRQGYE
                     EGYLRKSVVSPINRVNTKDNTPAVIHYDMVKGDKIKIEFAAKGFGSENMSKMKMLKPS
                     DGLEGIKKFIIDTVSEAGPNPCPPMVIGVGIGGTVDKCAQIAKKALFRELGEFNKDEN
                     IAKLESELLTAINKLGIGPQGLGGTTTALGLNIETFPTHIAGLPVVVNINCHASRHKK
                     VVI"
     gene            10044..10592
                     /locus_tag="KRO40_002839"
     CDS             10044..10592
                     /locus_tag="KRO40_002839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S-containing hydro-lyase"
                     /protein_id="HBH2093652.1"
                     /translation="MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCIN
                     KGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTSYRMDDLTIPLLERGLRLMIGKG
                     KRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
                     TVAIDSYGNNIYEQGRAIYECK"
     gene            10658..11839
                     /locus_tag="KRO40_002840"
     CDS             10658..11839
                     /locus_tag="KRO40_002840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent malic enzyme"
                     /protein_id="HBH2093653.1"
                     /translation="MSKDYAKLALEMHEINKGKVSVESKVEVKTKDDLSTAYTPGVAE
                     PCLKIHENQDDVYRYTSKGNLVAVVSDGSAVLGLGNIGAEASIPVMEGKAILFKQFAD
                     VDAFPICLKTNDVDEIVKSVELMEPVFGGINLEDISSPRCFEIEERLKKSLSIPVFHD
                     DQHGTAIIVAAAIINSIKLIENKKIEDLEIVINGAGAAGIAIAKILLNMNVKNIILCD
                     RSGALEASIENLNYVQKEMLKVTNIRNEKGPLKDIIKGKDVFIGVSGPGAVTKEMVES
                     MSEKPIILAMANPTPEIMPEEAKLGGAFIMGTGRSDFPNQVNNVLAFPGIFRGALDVK
                     AKEINEEMKIAAAYAIANTISDEEICPEYILPDVFNKNVVKNVAKAVKEAAIKTKVNR
                     I"
     gene            12134..12520
                     /locus_tag="KRO40_002841"
     CDS             12134..12520
                     /locus_tag="KRO40_002841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093654.1"
                     /translation="MEYKVNDQELNASMFIPFVNRIWPGDYDMDKTQTALSKTLNITA
                     YDDKVLVGCLRVLSDGYYFGTITELLVLPEYQKQGIGSKLFQLAKENTPTMLYFGAQP
                     GVEEFYEKNGCQRSLQSYIIKKKDSY"
     gene            12670..12933
                     /locus_tag="KRO40_002842"
     CDS             12670..12933
                     /locus_tag="KRO40_002842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBH2093655.1"
                     /translation="MEETKFCQCCAMPMGQTDELYGTNKDGSKSTDYCSYCFKDGEFT
                     ADISMEEMIEVCIPHMLQSNKDMTEDEARTMMNNFFPTLKRWK"
     gene            complement(13062..13904)
                     /locus_tag="KRO40_002843"
     CDS             complement(13062..13904)
                     /locus_tag="KRO40_002843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBH2093656.1"
                     /translation="MINIGDFNKLTVKRKTEFGYFLDGQTNNTKDDILLHNRLIGKNE
                     INIGDEVNAFIFKDSDDRTAATLIPPLAKVGDVAHLKVVDNTDIGTFIDMGLPKDILV
                     PFKAKTYPLFRDEKYLFYIYLDKSKRIAATTDIDSYLLTDHTYNVGDIVTGVVYGFQT
                     NNSAMICVDNKYAGVILHNEYFTELKTGDVLENLHVIKIYEDGKLGLSPRGNRKDELD
                     TLENKILSYLEGSDGYMRFNDKSDPKDISILFNSSKKNFKRALGVLMKKGLIYQDEEG
                     TYLK"
BASE COUNT         5546 a         1475 c         2496 g         4443 t
ORIGIN      
        1 tattaattaa gaatgatgaa atatgaataa agattttaca aataaatctt aagctatctt
       61 atttaattct aatacaggaa gaaggtaaat gtatattgaa aaaatcatag aaatagaagt
      121 aaacaattta aataaataca aaggtttgca aaagaagtaa tataattata tacaatgagg
      181 atgtgagtat gatgaacaga ctaaagccaa gaattttagg tattagtatc ttgtttatta
      241 ttataattat tttaacatgt ggagctgttt tcaagtttaa atttaaatta gataataaat
      301 taaaagaaac cacacataca tatttgtctg agtttacaga acacaatata attaatctca
      361 agacaagact tagtggtcaa tttgacatgc ttgaatctat tgctaacttc ataggaaact
      421 tgaataatat aaatgatgaa atggtgattg atttaatgga ttctgatgta aagcgaagtt
      481 ctttaattag aatgactatc tctacattag atggggaatg ttattctaat gatggaatta
      541 cccataatgt tcaagataga gattatttta aaaaagctaa aaatggagaa aagaatatat
      601 cagagccttt aaaatctatt gttaataata aagaaataat agttttatct accccagttt
      661 ataaaagtgg gaaaatagtt ggtgttttaa gtggaattta tgattcaaaa aagttaaatg
      721 agttattagg attatctgca tttgatgaaa aagcagatgt ttttgttgca aagaaaaatg
      781 gagatatagt tgctcaaaaa acaaataaaa atagaaagac gctatcatgt atatttcagc
      841 tttttgacaa agataattgt gatgaagatg attgtctaaa aactataaaa gaaaatatga
      901 aaaatgataa gtctggatat tttaattata acttagataa tgaaaaattt atgttaaact
      961 atcagccact tggagttaat gattggtatg ttttttctgt tgtgccaaat aaaatagtat
     1021 ctattcagtc agagaatata tcttatgatg tatatatttt tgcattagaa atactactag
     1081 ttatattgat ttttataata tatatagcat gtattataaa taataacacc aaaattatta
     1141 taaatgaaaa agaaaaattt aaagtactca ctgataatat attaggaggg gttaaaacct
     1201 gtttaaaaga tgaatatatg actatgacat atgtaagtca ggggttttta gagcttacag
     1261 gttactcttg tgaagattta aataaaatat ttaaaaatag atttaaagac atgatttata
     1321 aagatgattt agacaagttt aattgtatta ttctaaatca attagaaaaa caagataaaa
     1381 ttgaagttga atatagaatt gtaagaaaag atggaagtat aatttggatt ttggagagaa
     1441 gtaagtctat aaatgataat aaaggaagtg agtgtattca gggagtttta actgatataa
     1501 cagaacttaa gaaaatacaa gaagaattag attcaaaaag atttgaaata caggctatca
     1561 atgatagtat tgttggtgga atagtgataa ctgagataaa tgatgatttt gatagtatat
     1621 atttaaatga aggttattta aatatgattg gatatacacg caaacaactg gaagatgagc
     1681 taaataataa attaatcaaa cttattttta aagatgatag aacagaatta attaatagta
     1741 taaacaaaca actcaaatta agtgatacat ttgcatctga acaaagagtt gaaaaaaggg
     1801 atggcactat tatatggatt ttattaaaag gaagaaagat gatttatgat aatggaaaat
     1861 ctgtactttg ttgtgttatt gtagatatta cttctgctaa attattagag caagaactta
     1921 aaaagagtga agaacgtcat gaaatcattc taaagcagac gcaaaatatt ataatagaat
     1981 gggatataga aaaagataaa atgaatatat cacctaattg gtataataag tttaaatatg
     2041 accctataac tgaaaacgca acaaaaaata taattaaatc agtagatata tatcatgatg
     2101 atatggataa gtttatttca ttaattaaac ttacttcaca aggtagtgag tatgaagagt
     2161 gtgaaattag acttagaact agagatacta tttacgcttg gtttagtata aaggcaacaa
     2221 ctttatttga taataatggt aaaccttata aagtagtagg aagtttgact gatattgatg
     2281 aatcaaaacg agaagctgaa aagttgaaag aaagggcaga aaaagaccct cttacagatc
     2341 tgtataataa aaaagcatca caatcactta tagaggagta cataacattg gataaaaaaa
     2401 gaaaaggtgc tttaatgatt attgatattg atgactttaa aggaataaat gataatttag
     2461 gacatttata tggggatgct gtattaagtg aaattgcaaa tgacctaata aatctattta
     2521 gagcaaccga tatagtaggc agaattggtg gagatgagtt tattgtattt ataaaagata
     2581 tttctgaaac aagagatatt ataaataaag cagaagaatt ggtaaaaaca tttgaaaggt
     2641 cttttttagg taaaggacga aattataaaa tatcattaag tgtaggaatt gctaagtttc
     2701 cacaagatgg tatggactat atgacactat ttagaaatgc ggatatagct ctttactcag
     2761 ccaaagggaa gggcaagaat tgttatacat tgtatgataa aaaatttgat aaagtccaat
     2821 atataactaa tacaagaaat gcaggagata gtgataatgt agagatgtct tttaaagaac
     2881 atatcacaaa ttatatattt gatatactat atgaatcaag tgatatagaa gtggcagtaa
     2941 atttaattct aagtattgta ggtaaacact ttaatgtgag tcgcatgtat atatttgaaa
     3001 attcagatga taatcgagta tgtaaaaata catttgaatg gtgtaacgaa ggtgtaacct
     3061 cggaaattaa taatcttaaa aatatttgtt acaaggattt aggcaactat cttttaaatt
     3121 ttaatgcaga tgggttattt tattgtaatg atattgaaaa tttaggtagt gatgtgaaaa
     3181 aagtacttaa gccacaaggc atacgttcaa tattacaatg taaaatttta gagggtaatg
     3241 aatttagagg gttcatagga tttgatgaat gttcatataa tcgtatgtgg actaatgatg
     3301 aagtgaacac tttgacattt atatctaaaa cgctcagtat gtttttatta aaaatgcgta
     3361 ttcagagtaa gctagaagag tctttaacaa ttcaaaaatc tgtgatggat aatatggata
     3421 tatgggcata tgttgttgac aggaatacct atgaattact atttatcaat aaaaaaatgc
     3481 ttgagtcagc accaaacact catgtaggtg atttatgtta taaagcgata tggaataatc
     3541 aagataaacc ttgtaaaaaa tgccctatga tatatttaaa agatggtgat gatacttata
     3601 aatcattcat gcataataaa aagtttgagg tacaggcaaa tataactaca actactttga
     3661 aatggtttga tggtaaagat gcatgtttaa tatttggaag tgaaataact agtattgaag
     3721 ctgaagaaaa tacttaaaat actgtgttat atatatactt aaaatcgcaa tttgaattta
     3781 ttagacttaa aatgtctata taaatcattt aagttgtggt tttaagtatt ttttatgata
     3841 taattaagcg ttaagaacaa aattaaaaga tacttttgta taaaaaaata tttgttaaat
     3901 atatattgag caggtgataa tatggaaaat aagtttttac caataagcaa acaagatatg
     3961 atagatagag gatgggaaga attagatttt gttctagtta caggagatgc ttatgtggac
     4021 catcatagtt ttggaacagc aataatatct agagttttag aaagtgctgg gtataaagtt
     4081 ggaataatag ctcaaccaga ctggagaact acagatgatt ttatgaagct aggaaaacct
     4141 agacttgcat ttctagttaa tgcaggaaat atggattcaa tggtcaatca ttattctgta
     4201 agtaaaaagc atagagaaaa ggatatgtat tctccaggtg ggaaaatggg ttatagacca
     4261 gatagagcta ctatagtata ttgcaataaa ataagagaag catacagtga tgttgcaata
     4321 gtaataggtg gaattgaagc gagcttaaga agatttgcac actatgatta ttggagtgat
     4381 aaggttagaa agtctatgtt aatagatagt ggagcagatt tattagttta tggtatgagt
     4441 gaaaagcaga ttgtagaagt agccaatgca cttaatgatg gatatgaccc aaaatacatt
     4501 agacatattg atgggacatg ctatatttca gatacattgg aagaaatata tgataaatat
     4561 atattaattc catcatataa agaaatttgt gaagataaaa tgaagtatgt agaagctttt
     4621 aaaattcaat atgatgagca agacccattt agaggtaata taattgttca acctcatgga
     4681 agtaagtatc tggttcaaaa taagccagaa aaaccactta gtagagaaga actagatgaa
     4741 gtatatggat taccatatca gaagacatac catcctgtgt atgaaaaatt tggaggaata
     4801 ccagctatag aagaagtaaa atttagtata gtaagttcaa gaggctgttt tggtagttgt
     4861 tcattttgtg caataacatt tcatcaaggt agagcagtgc aaagtagaag tgaaaaatca
     4921 attattgatg aagcaatagg aataacaaat ttagatgatt ttaaagggta tatacatgat
     4981 gttggaggtc caacagctaa ttttagaaga ccagcatgta aaaaacaaat tactaaaggt
     5041 gcttgtaaaa atagacaatg cttatctcca tcaccatgta aaaatttaga tgcagaccac
     5101 agtgaatact tacatttact tagagctgta agaaaattac ctaaaataaa aaaggtgttt
     5161 gtgcgttctg gaattagata cgattatgta atggcagata agaacaataa atttcttaga
     5221 gagttgatag agcatcatgt aagtggtcag ttaaaggtag ccccagaaca tatatcagaa
     5281 gaagttttaa agtatatgca aaaaccagca ggaaaaactt atgataaatt tagacagaag
     5341 ttttttgcta taaatgaaga attaggtaaa aagcaatatt tgatacccta tttaatgtct
     5401 agtcaccctg gttctacctt aaatagcgct atagagttag cagagtattt aagagatact
     5461 cactaccaac cagagcaggt tcaggatttt tatccaactc cagggactct atctacaacc
     5521 atgttttata caggtattga cccgcttaca atgaagccag tttatgttcc taaatcaaaa
     5581 cgtgacaagg cgatgcaaag ggctttatta caatatagag cacctagaaa ttatgatttg
     5641 gtatactctg cgttagttga agcaggaaga gaagacttaa ttggttttgg acatagatgt
     5701 cttataaagc caaaaaatga aaagccttat tttaatagaa ataattctaa aaaaaatgta
     5761 tctaaaggaa caaataaaaa caaaaaaact aatacaaata acagaagtaa taaaaatcaa
     5821 caaaaaagtt caactaaaaa aaagaaaaaa cattaaagta taaataaaaa tacttaaaaa
     5881 agaaggatta ttcgataaat taacagaaat tagtataaat aaatataatt attttaatga
     5941 cgttaccttt gggaggaaga gatgaaaaag tatatttcta taatattatt agtggtgttg
     6001 actatggttg ttttggtagg atgttcacca ggaaaagata accctaaaaa taaggagcta
     6061 tcagttgtca aacaagtaaa agtagctgtt ccagatggac taccagcagt ggcaatagct
     6121 aaacttgcaa atgaaaatcc agagattaaa gaaggatatg aaacagtgta tagcattgaa
     6181 aagacacctg aagcgatttc cactagagtg atgaaaaaag atgcagatat agctatagtt
     6241 ccttcaaaca tggctgcaat agcgtataat aaaacttcat catataatat tgttggaact
     6301 gtaggaatgg gttcacttta tttggtgtca acagaaaata taaaagatta ttctgattta
     6361 gttggtaaag aagttggatg tactggaaaa ggacttactc cagacataac tataaaaagt
     6421 cttttgttac aaaaggatat aaattattca gatataaaat ttaattatgt aaattcagca
     6481 agtgaactgg taccattatt ggctactggt aaagttaaaa caggtattgt tccagaacct
     6541 gcacttagtg ctttgatgtc taaaaatcca gacataaaaa ttataaaaag tttaaatgac
     6601 tcatggaagg aagtaagtgg ttcaaaagat ggttatcctc aatctacttt aattgtaaag
     6661 tctgaatttt taagagataa taaagatttt gttgattctt ttgtaggtca attatcaaat
     6721 agtatagatt gggcaaacaa aaatcctgaa gaattaggtg catattctga aaaaataaaa
     6781 atatctactg aatcaaagat aataggaaaa tctcttgaaa gagctaattt aaaatatatt
     6841 ccagttaagg acatgattaa agattataaa aattactatg agaaattagc taattttgat
     6901 gataagacat taggaggcaa agtaccagat gaagcaatat actttgttga gaaataaaaa
     6961 aataaagaac aatttataga taaaatggag gtaacacttt cttgtgttat cctcttattt
     7021 ttatggcaaa ttattgcttt aaaaattgat aatgatattt ttttaccaac agtaggtcaa
     7081 gtatttaata gtataaaaga gattatgcta aattctagtt tctatataga tatactttac
     7141 tctatgggga gatgtttttt tagtttttta ctggctatga tttttgctat tatactttca
     7201 atagtgtctt atttaaatag attttttaga aacttattaa agccaatcaa tgctttgaca
     7261 cgttcaatac caactatgat attggtagta cttgcactta tttggtttga aaaggatagt
     7321 acccctttta tagttggatt tactatagtt tttcctatat tgtatgataa cgttttgggc
     7381 gctatattga atatagacaa gaacttatta gaaatggcta atgtgtataa aataaggttt
     7441 atagataagg tgttaaaaat ttatttacca gccataaaat ttcaaattat atctatacta
     7501 gtatcaacat tctctttaag tttgaaagtt gctatagcag gagaggtata tagtcaacct
     7561 acatatggta ttggaactat gatacagact gaaaaaatta actttaacac atctggaata
     7621 tttgcatgga taattattgt tcttttaata tctgctattt tacaaatagc tcaaaagttt
     7681 ttagcaagga gagctttttt atggaaaaga taaagttgag tattgaaaat ataaataaaa
     7741 gatatgatag tcgtattata tttagagatt ttaatattga tttttatgta aatgaggtaa
     7801 attgtatcct tggaaaatct ggttgtggaa aaactacact cttgaacata ataagtggga
     7861 ttattaaaaa tgacaccaac aatctaaata tcaaagaaaa tttaaataga gtaggaaata
     7921 agcttgaagc tagttacata tttcaagatg atagacttat agactggtta acagtagaag
     7981 aaaatataaa gatagttgta aataaatact ataataaaac tcaattaaat aaaatttgtg
     8041 atgaatactt ggaattggtt ggaattagtg attataaaaa attctatcct cagatgctta
     8101 gtggaggtat tagacaaaga gtaaatattg ctagagcttt tatatatcca tcaaaaaata
     8161 ttataatgga tgaacctttt aaatctattg atgcaaagaa tacacagctt ataatggata
     8221 atttcagaaa tatattaaga aaagaaaaaa gaactgtgtt atttgtaact cataatattg
     8281 aggaagcatt gtttttagca gataggatat ttattttagg agactctcca attagaataa
     8341 aaaaaatatt aaaaaattct aaggaattgg aaaaaaatga agttttgaag ttgatataga
     8401 gttataataa tactgtcgtt ttaaaatata tttggttaaa atctataaga ctatattaaa
     8461 atagtacaga atattcaaaa ctgtgtataa tgttcgtatt ttataaaaag gaagtgaatg
     8521 tatggttaag actaatgcta tgagaatatt agattcaaat aagattgatt ataaagtaat
     8581 gtcttatgaa gtgaaaagtg aacatgtgga tggtgttgag gtggcacatg atataggaag
     8641 agatgtaaat gaagtgtata agacattagt aactcaagga gttagtaaga atatatatgt
     8701 atatgtaata ccagtacatg aaaacttaga cttaaaaaag gctgcaaaag tagctaaaga
     8761 gaaaagtgta gagatgattc atgtaaaaga tataaataag cttacaggtt atattagagg
     8821 cggatgttct cctataggta tgaaaaagct ttataaaact tttgtaaatg aaagtgcaaa
     8881 gaatttagat acaattattg tgagtgcagg aaaaatagga tatcaaatag aactatctcc
     8941 atttgattta caaagactta taaaagtaga atttgtagat gtaataaaaa aataagaatt
     9001 acatataaaa tatagagctt atattcttaa taataggtgt tgtagtatta ataaaatgaa
     9061 taataatttt aaaataaata ttcagttact tatgtgtaat tggtataaaa atattgagaa
     9121 attttaaaaa caatggtaaa gtgtaagtat aatcacgaat attttttata aagtaatgga
     9181 gggatgttcg cttgagaaaa ataaaatctg aacaaatcgt cgagcaggta aaaaaacttt
     9241 gtatagaagc gagcctatat ttaggagaag atgttttaag ctgtataaaa gaaaaagcga
     9301 aaagtgaaaa gagtgaagtt ggaaaaaata tattgaatat attagttgaa aatgctgaaa
     9361 tagctaaaga aaaaaatata ccaatatgcc aagatactgg tatggctgta ttttttgttg
     9421 aaataggaca agaagtttta attgaaggag acacacttac tgatgctata aatgagggag
     9481 taagacaagg gtatgaagaa ggctacttaa gaaaatctgt tgtaagtcca attaacagag
     9541 taaatacaaa agataataca cctgctgtta ttcattatga tatggtaaaa ggtgataaaa
     9601 ttaaaataga atttgcagct aagggatttg gaagcgaaaa tatgagtaag atgaaaatgt
     9661 taaagccatc agatggattg gaaggaatta aaaaattcat aatagataca gtttcagaag
     9721 ctggacctaa cccatgccct cctatggtaa ttggagttgg tataggtggg actgtggaca
     9781 aatgtgctca aatagctaaa aaggcacttt ttagagaact aggtgaattt aataaggacg
     9841 aaaatatagc aaaacttgaa agtgaactat taacagctat taataaactt ggtataggac
     9901 ctcaaggctt aggtggtact acaacagctt tgggattaaa catagagact tttcctacac
     9961 acatagcagg tttacctgtt gttgtaaata taaactgcca tgcatcaaga cataagaagg
    10021 tagtaattta ggaggaaaat aaaatgataa aaataactac acctgtaaat gaaattgata
    10081 tagcaaaatt aaattgtgga gatacaatta gtttgagtgg tatactttat acagcaagag
    10141 atgctgctca taaaagattg atagattgta taaataaagg tgaagaatta ccatttgacg
    10201 tatatggtca aggaatatat tatgtaggac ctactcctac aaagccagga gaagttatag
    10261 gtgctgcagg tccaacgacg agttatagaa tggatgattt gactatacct cttttagaaa
    10321 gaggtcttag attgatgata ggcaagggaa aaagaagtga tgaagttata gaaggtatgc
    10381 aaaaatacgg agcagtttat cttgctgcaa taggaggagc tggagcatat atttcaaatt
    10441 caataaaatc atgtgaaatt attgcatatg aagatttagg agctgaagct ataagaaaga
    10501 ttgtagtaga agaccttaag cttacagtag caatagatag ctatggaaat aatatatatg
    10561 agcaaggtcg agcaatttat gaatgtaaat aatgtttaga aataaatatg aatatcaaaa
    10621 ttaaaaatag ttgtgtatat tttaaggagg aaaattgatg tctaaggatt atgcaaaatt
    10681 ggcattagaa atgcatgaaa tcaacaaagg gaaagtaagt gtagaaagca aggtagaagt
    10741 taaaactaag gatgatttat caacagcata tacaccaggg gttgctgaac cttgtttaaa
    10801 aatacatgaa aatcaagatg atgtttatag atacacttct aaagggaatc tagtagcagt
    10861 agttagtgat ggaagtgctg tacttggatt aggtaacatt ggtgctgaag catctatacc
    10921 tgttatggaa ggtaaagcta tattatttaa acaatttgca gatgtagacg cttttccaat
    10981 atgtttaaag actaatgatg tagatgagat agttaaatct gtagagttga tggagcctgt
    11041 atttggaggt ataaatttgg aagacatatc ttctccaaga tgttttgaga tagaagagag
    11101 attaaaaaaa tctttaagta tacctgtttt tcatgatgac caacatggga cagcaataat
    11161 agttgcggca gccataataa actcaataaa gttaattgaa aataaaaaaa tagaagattt
    11221 agaaatagtt ataaacggag caggagctgc tggtatagcc atagcaaaga tactacttaa
    11281 tatgaatgtt aaaaatataa tcttatgtga tagaagtgga gcattggaag ctagtataga
    11341 aaatctaaac tatgttcaaa aagaaatgtt aaaagtaaca aatataagaa atgaaaaagg
    11401 acctttaaaa gatattataa aaggaaaaga tgtatttatt ggtgtttcag gtccaggagc
    11461 tgttacaaag gaaatggttg aaagtatgtc tgagaagcca ataatattgg caatggcaaa
    11521 tcctactcca gagataatgc cagaagaagc aaaattaggt ggagcattta taatgggaac
    11581 aggtcgttca gacttcccta atcaagtcaa taatgtactg gcttttcctg gaatatttag
    11641 aggtgcactt gatgttaagg ctaaagagat aaatgaagaa atgaagatag ctgctgcata
    11701 tgcaattgct aatacaataa gtgatgaaga aatatgccca gagtatatat taccagatgt
    11761 atttaataag aatgtagtaa aaaatgttgc taaggcagtt aaagaagcag cgataaaaac
    11821 caaagtaaat agaatataaa tttttatatg ttcatatatc cttatattat cgggtatatg
    11881 ggcattttta ttataggttt atactcatat atccttactt ttatatacat atctttatga
    11941 ttaaaggtgt tagaaaatgt agtaaatttt atactatcag actctatctt tattacttta
    12001 gtagatacat ggttgtaaag gtttatagaa aaaaatatag gaaggcagat ttttattgtt
    12061 gcgtatatat gagaatgata taatatgaat attataaatt aataaattta aatttatgga
    12121 ggtacaagag atgatggaat ataaagttaa tgaccaagaa cttaatgctt caatgtttat
    12181 cccattcgtc aacaggatat ggccaggaga ttatgatatg gataaaacac agactgcatt
    12241 atcaaaaact ttgaatataa ctgcttatga tgataaagtg cttgtaggat gtctgcgagt
    12301 tctttcagat ggttattatt ttggaacaat tacagaattg cttgttcttc cagagtatca
    12361 gaaacaaggc attggtagta agcttttcca gcttgctaaa gagaacaccc caactatgct
    12421 atattttggt gcacagccag gagtagaaga gttctatgaa aaaaatgggt gccaaagaag
    12481 tctgcaatcc tacataataa aaaagaaaga tagttattaa agttccagct ttcaataatc
    12541 ttaaaagtac aatattttag tggaagcatt tcatttttta ttactaatat gacataaaca
    12601 tgtcatatta gcattgatat acttttaata tggttaagag ccaaagaaaa atataaggag
    12661 tgatttaaaa tggaagaaac taaattttgc caatgctgtg caatgccaat gggacaaact
    12721 gatgaattat atgggacaaa taaagatgga agtaaaagta ctgattattg tagttattgt
    12781 tttaaagatg gtgagtttac agctgatata agtatggaag agatgataga agtttgtatc
    12841 cctcatatgc ttcaaagtaa taaggatatg actgaagatg aagcaagaac aatgatgaac
    12901 aatttctttc caacattaaa acgctggaaa taattttatg caaaattagt tatatgcaaa
    12961 acatgaaata tggtgttgag aataaggggt ggtgtgcttt atagcatacc acctgttttg
    13021 ttacttggag ttcagttatt ttcctaaata ttttaaatat actattttag ataagttccc
    13081 tcttcatctt gataaattaa tccttttttc ataagcactc caagagctcg tttaaaattt
    13141 ttcttacttg aattaaataa tatagaaata tctttaggat cagatttatc attaaatctc
    13201 atatatccat cagaaccttc taaataactt aaaatcttat tttctaaagt atcaagttca
    13261 tcctttctat ttcctctagg agaaagacca agttttccat cttcatatat ttttatgaca
    13321 tgtaaatttt caagaacatc accagttttt agttcagtaa agtactcatt atgaagtatt
    13381 acaccagcat atttattgtc tacacatatc attgcagaat tattagtttg gaatccatat
    13441 acaactccag ttacaatatc tcctacattg taagtatggt ctgttaataa atatgaatct
    13501 atatctgtag tagcagcaat tcttttgctt ttgtctaaat atatataaaa taaatatttt
    13561 tcgtctctaa atagtggata agtcttagct ttaaaaggaa ctaatatgtc tttaggaagt
    13621 cccatatcta taaaagtacc aatgtctgta ttatcaacta cttttaaatg tgctacatcc
    13681 ccaaccttag ctaaaggcgg tattaaagtt gcagcagttc tgtcatcaga atctttaaat
    13741 atgaaagcat ttacttcatc acctatgttt atttcatttt ttccgattaa tctattatga
    13801 agaagtatat cgtcttttgt gttattagtt tgtccatcca aaaaatatcc aaattcagtt
    13861 tttcttttta ctgtaagttt attaaaatca cctatgttta tcaaattaaa atcatcctct
    13921 cattttatat ttataattta gccataatat acttatgtag
//
LOCUS       DAEQCW010000097        13883 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.098, whole genome shotgun sequence.
ACCESSION   DAEQCW010000097 DAEQCW010000000
VERSION     DAEQCW010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13883)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13883)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13883
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.098"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            17..2194
                     /locus_tag="KRO40_002844"
     CDS             17..2194
                     /locus_tag="KRO40_002844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2093657.1"
                     /translation="MYNKYNNLYLLLGKENVNMDSYRQLKAKIPCKETGIEIKRTLCD
                     ICSPGVHCGIDAYVKDGKVIKIEGTKEHPMNKGLLCTKGLCNREYIYREDRIKTPLKR
                     IGKRGEGKFKPISWDEAYREIAEKLNRVKSEYGAKHVAFFTGYGKWYRPFLQRFASSF
                     GSPNYGTESSSCSTSAQMAGNVATGRNFTMQDMENAKTYLGWGFNPYYSKFLNSVNLI
                     KLKEKGLKFIIVDPRITPTTQKLADLHLRIKPGTDGALALGMANLFIQKNLIDREYIE
                     KYVHGFNEYKEYVKLFDLDTVSRITGVSKDNIVKAVEMLSQGPFCINESAAPIVHHQN
                     GFQNYRAMMSLSAITGNYDRIGGNIPKQDYFAGKIGGFQTLEKEFVKEVLPKNINERI
                     GGERFPLWNEMVTQFQAMDLPRQIEEKTPYEIRALFCHGINARMFPNSGRLFKALNSV
                     DFFVNIDLFMTDTSKYADILLPACTSFEREECKSYPGGYITYTKKVIDKLYDSKSDVE
                     ILSDLANAMNIDDDLLKAGYEASIRHMFKNTCVDVDKLKESDLPLKCKDFKPYIVGSY
                     TREGYDTSTSRFELKSTIIEKYKDFGLDALPTYRGFNDNIDDEYTHLLTSGARISNAL
                     HSRLHDIKLSRILKNEASCDISSLDAKELGVISGDYIKITTKIGSLDVKVNVTDRVLY
                     KNIHMYHGYREADINSIICDNFDPYSGFPAYRSCKCKIEKMNR"
     gene            2208..2630
                     /locus_tag="KRO40_002845"
     CDS             2208..2630
                     /locus_tag="KRO40_002845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2093658.1"
                     /translation="MKSLFKFNKELCTACGACLLACIDQNDNNIDNGELFRHVFTIEE
                     GENIEYFSLACIHCNEPKCLGVCPKNCFKKEEGFVVLDNQNCIGCKLCEKACEYGALI
                     YGNDGKANKCNGCIERYKCGMDSPCVMVCPTGALKFNK"
     gene            3038..3841
                     /locus_tag="KRO40_002846"
     CDS             3038..3841
                     /locus_tag="KRO40_002846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH2093659.1"
                     /translation="MKKLKLIIMFALVSALLVTGCSSGNNKNKEEQKVIRVATSGTYY
                     PFAFKDKDKLKGFEVDFWDEFAKRTNCKVEWVLTDFSGLFGLLEADKADVVSAQLTAT
                     PEREKKYAFSDAYNYSGTNIIVREDDTSIKSIDDLVGKKVGVGTGAVANEILKEKYPN
                     DEIKIVNYSSATLKGNYQDLEMGRLDAVVAQDVEALIAIKEQKLNLKMIEPPIQFGAC
                     SFALQKNEKGEKWTKEINEVIEEMYKDGTLTKISENWLGKDITKEPINE"
     gene            3834..4502
                     /locus_tag="KRO40_002847"
     CDS             3834..4502
                     /locus_tag="KRO40_002847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH2093660.1"
                     /translation="MSNFNFEFCLSIFPFLIKALGITILISIVSFFLSILLGVILAFF
                     TQTKSKVLQYITRVYVSFFRGTPLLIQIFFFYFGFPMIFSFMKDCSPYLAIVICLGVN
                     SSAYMAEIIRASIESVDKGQQEACYAFGLSKYQSMVKIILPQAATSAVPPIVSCTLDI
                     IKGSSLGLTIGIQDLMGVAQVEAASSFKYFEIYMITILIYWAVSIILSNIQSKVEKRI
                     RRAY"
     gene            4738..5400
                     /locus_tag="KRO40_002848"
     CDS             4738..5400
                     /locus_tag="KRO40_002848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH2093661.1"
                     /translation="MAFNMKYFLELFPTIMKSFNVTVILAISSLVFSLIIGTIVALSS
                     YYKVKVLNQICKVYVSIFRGTPLMPQLFFLYFGLAYMSDFVKNMDPVFATSIVLSLNM
                     GAYMSETIRASILSIDTGQIEAAYAMGLTNLQTMKRIVIPQAVRVALPSLFNNFIDLI
                     KGSSVAFVVGVNDIMGAAKSQGALSFKFFEVYGAVMVIYWCIITPLGWGQKKLEKKIS
                     NY"
     gene            5460..6257
                     /locus_tag="KRO40_002849"
     CDS             5460..6257
                     /locus_tag="KRO40_002849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2093662.1"
                     /translation="MIKRNIIKCLVAVLSLTFVITGCSKKEEVKNEKVITVASSNSAD
                     PYSYVDNGEHKGFEVDMWKEIGKRSGYKIKMEPTGFSSIFGMLDSGKVDVAANFFGMS
                     KERLEKYDASIPYGSDSVCIAVKDGNNEINKLEDLKGKVVAVSEGSQGQQVATSVNKD
                     NLFQEKVYGDGTSGLQDLDLGRVSAWIDAELTIVGDAKKANMKVRVLDKKLSATNIAY
                     FFKKNDDKSKTIKEDVNKAIEEMLADGTVKKISEKWFGMDVSADIQK"
     gene            6375..7565
                     /locus_tag="KRO40_002850"
     CDS             6375..7565
                     /locus_tag="KRO40_002850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093663.1"
                     /translation="MEVLQMIETKIKSIALKNREKIIKIRRQIHSNPELAFKEYKTSK
                     LIKEELNKLNIEYINIAGTGVLATIKGKNNGGKTILLRADMDALPIKEENDLEFKSIN
                     DNMHACGHDAHVSWLLGTAMILNDIKEELNGNVKLLFQPGEEKGGSDIVIKENVLEGV
                     DALATGHCWPTIESGKIGIARNCAMAATNTFEITIIGKGGHGAEPHNCIDPIAVGNAV
                     YSSIQQIVSRKIDPVVPVVVSVCSFNSGVSKNIIPDVCTLQGTIRAISKEQVIEVSKI
                     LEYIVKNVCKAHGADCKFEKSTGGDAVINDKNMIEIGRESACKILGAENVEIIDFPAM
                     TGEDFAIYMKEKPGLFMYIGVGDKEKNINYRLHSNKFNIDEKCLSIAPSLFSQLTVDY
                     LCQL"
     gene            7674..8423
                     /locus_tag="KRO40_002851"
     CDS             7674..8423
                     /locus_tag="KRO40_002851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH2093664.1"
                     /translation="MIKVENLHKSFKGTEVLKGINLEISQSEVVAILGSSGTGKSTLL
                     RCLNYLVEPTKGKIMIGDVKVDVEKATKKDITNLRKHTSMVFQNYNLFKNKTALENVM
                     EALIVVHKKSKKEAREISLKLIDKVGMLDRKDFYPSKLSGGQQQRIGIARAMAVNPNV
                     ILFDEPTSALDPELVGEVLSVIKSLAKEGITMLIVTHEINFAKEVADKIIFMDNGVIA
                     EEGTPDEIFNNPKNERTAKFLNIIRKEEVFS"
     gene            9014..10075
                     /locus_tag="KRO40_002852"
     CDS             9014..10075
                     /locus_tag="KRO40_002852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="HBH2093665.1"
                     /translation="MRDFLKNYKSSIILLACTIVGAIVGLVLGPKASILKPFGDLFIN
                     ALLMIVVPLVFLSVSSGVASIKNMERFGKIMKGTAIVFMGTTLVIAFLGITSALLFNP
                     SKGLDVSSVKNLMVAQDAETLESKGTLLDQVVSSITVKNFGDLFSSSNLLQLVIFAVL
                     IGTAIAMMGDRGNTIRKLLSEGTEAILKVVSIFMLYAPIGLGCYTATIIGELGSKIIQ
                     GYVRVFVIYSLTAAMYFLLFYSLYAFLSAGKQGFRQFWRNAIKPIATALATSSSSACI
                     PSNLEASKNIGVPDDISETVIPLGINIHKDGAVLAVIIKVAFLSGILGSGMANPATIG
                     QLFITVFVVGVFMAPVAGG"
     gene            10088..10285
                     /locus_tag="KRO40_002853"
     CDS             10088..10285
                     /locus_tag="KRO40_002853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="HBH2093666.1"
                     /translation="MLVVSIFGFPVEAIPLLTVITTITDIPNTILNTTGNTVSSMLVS
                     RLVEGKDWLIDKTAITTKKIS"
     gene            complement(10449..11177)
                     /locus_tag="KRO40_002854"
     CDS             complement(10449..11177)
                     /locus_tag="KRO40_002854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH2093667.1"
                     /translation="MKTNYRLHMQQGSDYLKKFLEKHIDLLKKIPLFEGIKSDELEEM
                     LECLGVVDKTYPKDSIIFSVGSEVTSIGIMLKGSAHIIKEDIEGNRNIVAELLPGDLF
                     GEVFACTRLHKSNVTVTTTSSCEVLFIKFKSVTGICSSACVFHNRLVENMLQLIAEKN
                     ILLHNKIELLSRKTTREKLLMYFSKQIEQTGSHQFTIPFSRNEMADFLCVDRSSMSRE
                     LGKMRDEGLLSFNKNKFEIFYFQK"
     gene            11318..12043
                     /locus_tag="KRO40_002855"
     CDS             11318..12043
                     /locus_tag="KRO40_002855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2093668.1"
                     /translation="MMRKIIKIDEEKCNGCGLCVEACHEEAIGMVNGKAKLLRDDYCD
                     GLGDCLPTCPTNAISFEYREAAEYDEAAVKANMEAKKAQKKTLACGCPGSQSKSINRE
                     VSNSTSISNDIVEIKGSQLNQWPVQIKLVPTNASYLKNASLLIAADCTAYAYGNFHNK
                     FMKNKVTLIGCPKLDEVDYAEKLTEILKENDIKNIVVTRMEVPCCGGIVNAVKTALQN
                     SGKMIPWQIVTISVDGKIVDGEI"
     gene            12103..13695
                     /gene="hcp"
                     /locus_tag="KRO40_002856"
                     /gene_synonym="priS"
     CDS             12103..13695
                     /gene="hcp"
                     /locus_tag="KRO40_002856"
                     /gene_synonym="priS"
                     /EC_number="1.7.99.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxylamine reductase"
                     /protein_id="HBH2093669.1"
                     /translation="MEKMFCFQCEQTAGGKGCTINGVCGKKGGTANLQDELTGVLIGL
                     SRATIGNKNRPTSETDKIMIEGLFTTITNVSFDDEAIKRQIEKTEVEKSKLVPRCSDC
                     STTCNRNDNYDMKDLWNDNEDIRSLKSLILFGLRGMAAYAYHAMVLGYTDKDVNEFFY
                     EGLIAVGGDLSIDELLGLVMKTGEINLKCMELLDRANTETYGTPEPTQVSMKIEKGPF
                     IVVTGHDLYDLHKLLEQTKDKGINIYTHGELLPAHAYPKLKEYKHLKGNFGTAWQNQQ
                     KEFDNIPAPILFTTNCLMPVKDSYRDRVFTTEVVAYPGMVHIDEDKDFSSVIEKALEL
                     GGYREDVHMTGINGGDTLTTGFARGTVSSVQDKVVDAVKSGAIRHFLLVGGCDGAKPG
                     RNYYTEFVKQAPKDTVILTLACGKYRFNDLDLGDIGGLPRLMDMGQCNDAYSAIKVAV
                     SLANAFECGVNDLPLSMVLSWYEQKAVCILLTLLHLGIKNIYIGPSLPAFLSKNVLDI
                     LVDKFALTPISTPEEDMKKILG"
BASE COUNT         5406 a         1486 c         2503 g         4488 t
ORIGIN      
        1 tatttgaata aaaagaatgt ataataagta taataatttg tatttattat tgggaaagga
       61 aaatgttaat atggatagtt atagacaact taaagctaaa ataccctgta aggaaacagg
      121 tatagaaata aagaggactt tatgtgatat ttgttctcca ggagtacatt gtggaattga
      181 tgcatatgtt aaagatggta aagtaataaa aatagaaggt acaaaagaac atccaatgaa
      241 taaagggttg ttatgtacca aaggtctttg caatagagaa tatatctata gagaagatag
      301 aataaaaaca cctctaaaaa gaattggaaa aagaggtgaa ggaaaattta aaccaatatc
      361 atgggatgaa gcttatagag aaatagcaga aaaattaaat agagtaaaat ctgagtatgg
      421 agcaaagcat gtagcttttt ttacgggtta tggaaagtgg tatagacctt ttttacaaag
      481 gtttgcatct tcatttggtt cacctaatta tggtacagaa tctagttcat gttcaacatc
      541 agcacagatg gctggaaatg ttgctactgg aagaaacttt acaatgcaag atatggagaa
      601 tgcaaaaact tatttagggt ggggatttaa tccatactac tctaaatttt taaatagtgt
      661 gaatctaata aaattaaaag aaaaaggtct aaaatttata attgtagacc ctagaataac
      721 accgacaact caaaaactag cagatttaca tttaagaatt aaacctggaa ctgatggagc
      781 tttagctctt ggaatggcga atctatttat acaaaagaat ttaatagata gagaatacat
      841 agaaaagtat gtacatggat ttaatgaata taaagaatat gtaaaattat ttgatttaga
      901 tactgtaagt agaattacag gagtttctaa agataatata gtaaaagctg ttgagatgtt
      961 gtcacaaggt ccattttgta taaatgaaag tgcagctcca atagttcacc atcaaaatgg
     1021 atttcaaaat tatagagcaa tgatgtcttt atctgctata acaggtaatt atgatagaat
     1081 aggtggaaac ataccaaaac aagattactt tgctggtaag ataggtggat tccaaacact
     1141 agaaaaagag tttgtaaaag aagttctacc taaaaatata aatgaaagaa ttggtggaga
     1201 aagatttcct ctatggaatg aaatggtgac tcaatttcaa gctatggatt tacctaggca
     1261 aatagaagaa aagacaccat atgaaataag agctttgttt tgtcatggga taaatgctag
     1321 aatgtttcct aattcaggga gactttttaa agcgttgaat agtgtagatt tttttgtgaa
     1381 tatagattta tttatgacag atacatcaaa atatgcagat atacttttac ctgcatgtac
     1441 atcatttgag agagaagaat gtaagagtta tccaggaggg tatattacat ataccaaaaa
     1501 agttattgat aaattatacg attcaaaatc agatgtagaa atactttcag atttagcaaa
     1561 tgctatgaat atagatgatg atttattaaa agcaggttat gaagcaagta taagacatat
     1621 gtttaaaaat acatgtgtag atgtagataa acttaaagaa agtgatttac cattaaaatg
     1681 taaagatttt aagccatata tagtaggttc atatacaaga gaagggtatg atactagcac
     1741 ttctaggttt gaattaaaat ctacgattat tgaaaaatat aaagattttg gactggatgc
     1801 actaccaaca tatagaggat ttaatgataa tatagatgat gaatatactc atttattgac
     1861 atcaggagca agaatttcaa atgcactaca ttcaagactt catgacatca aactttcaag
     1921 aatattaaaa aatgaagcta gttgtgatat ttctagctta gatgcaaaag aattgggtgt
     1981 tatcagtgga gattatataa aaataactac taagatagga agtttggatg taaaagtcaa
     2041 tgttactgat agagtcttat ataagaatat acatatgtat catggatata gagaagctga
     2101 tataaatagt attatttgtg ataattttga cccttatagt ggattccctg cgtatagaag
     2161 ttgtaagtgt aagattgaaa aaatgaatag ataaatggag agatataatg aaaagtttat
     2221 ttaaatttaa taaagaatta tgtacagcat gtggagcatg tttgcttgca tgtatagacc
     2281 aaaatgataa taatatagac aatggtgaac tttttagaca tgtatttaca atagaggaag
     2341 gtgaaaatat agaatatttt tcattagcat gtatacattg taatgagcca aaatgtttag
     2401 gtgtatgtcc taaaaattgt tttaaaaaag aagaaggatt cgttgtatta gacaatcaaa
     2461 actgtatagg gtgtaaactt tgtgaaaaag cttgtgaata tggagcctta atttatggaa
     2521 atgatggtaa ggcaaataag tgtaatggtt gtattgagag atataagtgt ggtatggatt
     2581 caccttgtgt aatggtatgt cctacaggag cattaaaatt taataaataa attaaatata
     2641 gagaatgact tatacttagg tataagatat ttttacaaaa agctgtattg agtttgttat
     2701 aatgaaaact caatatagct tttttatgga tatagttgga tactataatg tgattcttag
     2761 taatagtttt ttgctattgg acaaagactg taaaacatat taaacttatg ttgttcaaag
     2821 tcgaagtata atataataac tagaaaattg gtttatagtg ctataaaagc aaatttagta
     2881 aggtataaaa tcagaggcaa tcctttacta taatatcaat atttgggagt tctgttattg
     2941 cagagctatt aaacaattat aatggtacaa gtgattcaac ctttgaaaat gtattatata
     3001 aaaaattaaa ataagattaa aaaggagaga ataaattatg aaaaaactta aattaattat
     3061 tatgtttgcc ttggtatcag cactgttagt tacaggatgt tcatcaggaa ataataaaaa
     3121 taaagaagaa caaaaagtta taagagttgc aacatcagga acatattacc cttttgcttt
     3181 taaagataaa gataaactta aagggtttga agtagatttt tgggatgaat ttgctaaacg
     3241 aactaattgt aaagttgaat gggtattaac tgattttagt ggattatttg gattattaga
     3301 agctgataaa gcagatgttg tatctgctca acttactgca acacctgaaa gagagaaaaa
     3361 atatgctttt tcagatgctt ataattatag tggaacaaac attattgtta gagaagatga
     3421 tactagtata aaatcaatag atgatttagt tggcaagaaa gtaggtgtgg gtactggagc
     3481 agtagcaaat gaaatattaa aagaaaaata cccaaatgat gaaataaaaa tagtaaatta
     3541 ttcaagtgcg actcttaaag ggaattatca agacctagaa atgggaagat tagatgcagt
     3601 agttgcgcag gatgttgagg ctttaatagc tataaaagaa caaaaattaa atcttaaaat
     3661 gatagaacct ccaattcaat ttggtgcctg ttcttttgcg cttcaaaaaa atgaaaaagg
     3721 tgaaaaatgg acaaaagaaa ttaacgaagt aattgaagag atgtataaag atgggacttt
     3781 gactaaaata tctgaaaact ggctaggaaa agacattact aaggagccta ttaatgagta
     3841 attttaattt tgaattttgt ctaagtatat ttccattttt gattaaagca ttgggaataa
     3901 caatactaat atctattgtt tcattttttt tatcaatatt attaggtgta atacttgcct
     3961 ttttcacaca gacaaaatca aaagttttac aatacataac aagagtgtat gtttcattct
     4021 ttagaggaac accactttta attcaaatat ttttctttta ttttggattt ccaatgatat
     4081 tttcttttat gaaagattgt tcaccttatt tagcaatagt aatttgttta ggtgtaaatt
     4141 catctgcata tatggctgaa attatacgag catctattga gagtgttgat aaaggacaac
     4201 aggaagcatg ttatgctttt gggttaagta aatatcagtc aatggttaaa ataattctac
     4261 ctcaagcagc tacatctgca gtacctccta ttgtaagctg tacactggac ataattaaag
     4321 gttcttcttt aggtttaact ataggaatac aagatttaat gggagtagct caagtagagg
     4381 ctgcttcaag ttttaaatat tttgagatat atatgataac gatattaatt tactgggcag
     4441 tatctataat attgagtaat atacaaagca aagttgaaaa aagaataaga agagcatatt
     4501 agatttcaat atttaaaaat gggatgatat agatatatta ttacttgtaa ataaattttt
     4561 aattttagaa aaataaactt agtaatctaa attattgaga aaatatagta tcaaaatgga
     4621 ctgtataatc aagttaaaaa atagtttttc tattgaaaaa ataaataaaa ttctattgta
     4681 atttaatatg cgataaagtt ttataaaaaa caacattaag ctagggggac ttattttatg
     4741 gcttttaata tgaaatattt tttagaatta tttccaacaa taatgaaatc gttcaatgta
     4801 actgtgattt tggcaataag ttcattagta ttttcattaa ttataggtac aatagtagcg
     4861 ttatcatctt attacaaagt gaaagtattg aatcaaatat gtaaagtata tgtatctatt
     4921 tttagaggta cacctcttat gccacagtta ttctttttat attttggact agcatatatg
     4981 agtgattttg ttaaaaatat ggacccagta tttgcaacat ctatagtact tagtttaaat
     5041 atgggagctt atatgtctga aacgataagg gcatctatac tttcaattga tacaggtcag
     5101 atagaagcag catatgcaat gggattaaca aatttacaaa caatgaaaag gatagtgata
     5161 ccacaggccg taagagttgc actgccatca ttattcaata attttataga tttaattaaa
     5221 gggtcttctg tagcttttgt tgttggagta aatgatataa tgggtgctgc caaatcacaa
     5281 ggagcgttga gttttaagtt ttttgaagtg tatggagcag ttatggtaat ttactggtgt
     5341 ataataactc ctttaggttg ggggcaaaaa aaattagaaa agaaaataag caattattaa
     5401 gttattaaga aaatacataa aagtattttt atataaaaaa tggtgtgagg agaagagata
     5461 tgataaaaag aaatattata aaatgtttag tggcagtttt atcgttaacg tttgtaatta
     5521 ctggttgttc aaaaaaagag gaagtaaaga atgaaaaagt tataactgta gcttcatcta
     5581 attcagctga cccatattct tatgttgata atggtgagca taagggtttt gaagttgaca
     5641 tgtggaaaga gattggtaaa agaagtggat ataagataaa aatggaacca acaggtttta
     5701 gttctatatt tggtatgtta gattctggta aagttgatgt ggcagccaac ttctttggaa
     5761 tgtctaaaga aagattagaa aaatacgatg cttctatacc ttatggttct gattctgtgt
     5821 gtatagctgt aaaagatgga aataacgaaa ttaataagct tgaagattta aagggaaaag
     5881 ttgtagcagt ttcagaaggt tctcaaggtc aacaggttgc aactagtgtt aataaagata
     5941 atttgtttca agaaaaggtt tacggtgatg gaactagtgg tcttcaagat ttagatttgg
     6001 gaagagttag tgcatggatt gatgcagagc ttactattgt gggagacgct aaaaaagcta
     6061 atatgaaagt aagagtatta gataaaaaat tatcagctac taatatagca tacttcttta
     6121 agaaaaacga tgataaatct aaaacgataa aagaagatgt aaacaaagca atagaagaaa
     6181 tgcttgcaga tggaacagtg aaaaaaatat ctgaaaaatg gtttggaatg gatgtaagtg
     6241 ctgatataca aaaataaata ctttaaaatt aaaatgtaaa actgtgataa ctatagataa
     6301 gtatactaaa tttatctata gttatctgtg tattacaatg tatttagatt agtctttata
     6361 aatcaaaatg agttatggag gtattgcaaa tgattgaaac taaaataaaa tccattgcac
     6421 taaaaaatag agaaaaaatt ataaaaataa gacgacagat acacagtaat ccagagttag
     6481 catttaaaga atataaaaca tctaaactta taaaagaaga gctaaataaa cttaatatag
     6541 aatacataaa tattgctggt acaggagtat tagctactat aaaaggaaaa aataatggtg
     6601 gaaaaactat attactcaga gcggatatgg atgctcttcc aatcaaagag gaaaatgatt
     6661 tagaatttaa atcaataaat gataatatgc atgcttgtgg gcatgatgca catgtttcat
     6721 ggttgttagg aacagcaatg attttaaatg acataaaaga agaattgaat ggaaatgtaa
     6781 aattactatt tcaacctggc gaagaaaaag gtggttctga tattgtaatt aaagaaaatg
     6841 tacttgaagg tgtggatgca ttagcgactg gtcattgttg gccaactatt gagtcaggaa
     6901 aaattggaat cgctagaaat tgtgctatgg cagcgactaa tacttttgaa ataacaataa
     6961 ttggcaaggg tgggcatgga gcagagcctc ataattgtat agacccaatt gcagttggaa
     7021 atgcagtata ttcatccatt caacagatag tttcaagaaa aattgaccca gttgtacctg
     7081 tagtagtgtc tgtttgttct tttaattctg gtgtttctaa aaatataata ccagatgtat
     7141 gtacacttca agggactatt agagcgataa gcaaggaaca agtaattgaa gtaagtaaaa
     7201 ttctagaata tatagtaaaa aatgtatgta aagcacatgg agcagattgc aaatttgaaa
     7261 agagtacagg aggagatgct gttataaatg acaaaaacat gatagagata ggaagagaaa
     7321 gtgcttgcaa aatacttgga gctgaaaatg ttgaaataat tgattttcct gcaatgacag
     7381 gtgaggattt tgctatttat atgaaagaaa aacctggttt atttatgtat ataggtgtag
     7441 gagataaaga aaaaaatata aattacagat tgcatagtaa caagtttaat atagatgaaa
     7501 aatgtcttag tatagcacct tcattatttt cacaacttac agtagattat ttatgtcaac
     7561 tatagagtac attcataaaa atatatttag cctattttta aatttaatgc tagtatatta
     7621 attttgatgt agaacatatt atttattata tttatttaaa aaggtggata acaatgataa
     7681 aagtagaaaa tttacataaa agttttaaag ggacagaagt tcttaaaggt ataaatttag
     7741 agataagtca aagtgaagta gtagctatac ttggatcatc tggaacaggt aaatctacgt
     7801 tacttagatg tttaaattat ttagttgagc ctacaaaagg aaagataatg attggtgatg
     7861 taaaagtaga tgtagaaaaa gcaacaaaaa aagatataac caatttaaga aaacatacat
     7921 ctatggtgtt tcaaaattat aacttattta aaaataaaac agcattagaa aatgtaatgg
     7981 aggcattgat agtagttcat aaaaagagta agaaagaagc tagagaaata tctttaaaat
     8041 taatagataa agtaggtatg ttggatagga aagattttta tccatcaaag ttgtctgggg
     8101 gacagcaaca aaggataggt atagcgagag cgatggcagt aaatccaaat gtaatattat
     8161 ttgatgagcc tacatctgca cttgacccag aacttgttgg agaagtttta agcgttataa
     8221 aatctcttgc aaaagaaggt ataacgatgc ttattgtaac tcacgaaata aattttgcaa
     8281 aagaagttgc tgataaaatt atatttatgg ataatggtgt aatagctgaa gaaggaactc
     8341 ctgatgaaat atttaataat cctaaaaatg aaagaacagc aaaattttta aatatcatta
     8401 ggaaagaaga agtatttagt taaaagtgta taaattaagc attagaagat atgtaagata
     8461 cccccattaa atttataagt tagataataa atttaatggg agtatatttt tattattaga
     8521 tttattattt aatttaaaat tagaaatgta actatttgaa aattcttttt aaaagtatat
     8581 caaaatatca aatacataaa aaaataatat ttgacaaagt atcatatgtg tttacaaaat
     8641 caactttatg gagttatata gtataggaat tacaatgaat atactaaaat tttatattaa
     8701 agtacaaagt attaaatttg aaaataatta agtaatatta tatatatttt tttatattgt
     8761 ttgttttatt aaaattaatc tagaaaaaaa gttttaaaag cagaatttta ttaatattta
     8821 tatatagata tgaactatta ataaaacgtt aaaaatacaa aaaaactata gaaattgaca
     8881 tatattccag tatttgctaa agtagctgtt ggggaaaatt acaaaaatta ttaatgcgca
     8941 ttagataatt tgctttaatt tttttagcat ttggggtaat ttataatata aagcattaga
     9001 aaggaaaata taaatgaggg actttttaaa aaattataag tcatcaatta tacttttagc
     9061 atgtactata gtaggggcga tagtaggatt agtacttggt ccaaaagctt caatactaaa
     9121 accatttgga gatttattca taaatgctct attaatgata gtagtaccat tagtttttct
     9181 tagtgtttct tcaggtgttg ctagtataaa aaatatggaa cgatttggaa aaataatgaa
     9241 gggtacagct atagtattta tgggaacaac acttgtaatt gcatttttag gtattacatc
     9301 tgcattatta tttaatccgt ctaaaggatt agatgtatca agtgtaaaaa atttaatggt
     9361 ggctcaagat gcagaaactt tagaatcaaa aggaacgtta ttagaccaag tagtatcaag
     9421 tattacagtt aaaaattttg gagatttatt ttccagtagt aatttactac aattagttat
     9481 atttgcagtt ttaattggaa cagcaatagc tatgatggga gataggggaa atacaataag
     9541 aaagctttta tcagaaggaa cggaagcaat attaaaagta gtaagtatat tcatgcttta
     9601 tgctcctata gggctaggct gttatacagc tacaataatt ggggaacttg gaagtaaaat
     9661 aattcaagga tatgtaaggg tgtttgtaat ttattcacta acagcagcca tgtatttctt
     9721 attattttac agtctgtatg cttttttatc tgcaggaaaa caagggttta gacaattctg
     9781 gagaaatgct ataaaaccaa tagcaacggc actagctact tcttcaagtt cagcatgtat
     9841 accatcaaat ttagaagcta gtaaaaatat aggagttcct gatgatatat cagaaacagt
     9901 tatacctctt ggaataaata tacataaaga tggggcagtt ttagcagtaa taataaaagt
     9961 ggcattttta tcaggtattt taggtagtgg aatggcaaat ccagcaacga taggtcaatt
    10021 atttataact gtatttgttg ttggagtatt tatggctcct gtagcaggtg gctgacttat
    10081 tggtgagatg ctcgtggtta gcatcttcgg ttttccagtg gaggcaattc cactgttaac
    10141 agttataact actataactg atattcctaa tactatatta aatacaactg gaaatacagt
    10201 atcatcaatg ttagtttcaa gattagtaga aggaaaagat tggcttatag ataaaacagc
    10261 aattactaca aagaaaataa gctaattgta cacttaatta ataaagttaa taggtatctt
    10321 aattttaata aattagatac ctattaactt tttaagtaaa aatataaatt taagattcaa
    10381 atatgatatt tataatttga atcaactaat atagtatata ttgaaataaa tatgtttaaa
    10441 tatctatttt atttttgaaa ataaaagatt tcaaatttat ttttgttaaa agataacaag
    10501 ccttcatctc gcatcttgcc aagctctctt gacatagaac ttctgtcaac acataaaaaa
    10561 tcagccattt catttcttga aaagggaatt gtaaactggt ggctacctgt ttgttctatt
    10621 tgttttgaaa aatacataag caatttctcg cgagttgttt tacgagaaag taattctatt
    10681 ttattgtgaa gtaaaatgtt tttttcagct attaattgta gcatattttc aacaagccta
    10741 ttatgaaata cacatgcaga tgaacaaata ccagttacac ttttaaactt tataaataaa
    10801 acttcgcaag aagatgttgt ggttactgta acattacttt tatgtagtct agtacatgcg
    10861 aatacctctc caaataaatc tccaggcaag agttcagcta caatattcct attcccttcg
    10921 atatcttcct ttattatatg agcacttcct ttaagcataa ttccaataga agtaacttca
    10981 cttccaacag agaatattat actatctttt gggtaagtct tatctacaac acctaaacat
    11041 tccaacattt cttcaagttc atcactttta attccttcaa atagaggaat ttttttaagt
    11101 aggtctatat gcttttctaa aaattttttc aaataatcac ttccttgttg catatgcaac
    11161 cgataatttg ttttcattgt actatactaa gtttataaaa gcaaggggat ataaaaatcc
    11221 tactacaaga aatttgaaat aaagaaatat aggtattaaa aataaatata taagaaatca
    11281 atactttaaa ttaaaaaaat tttatgaggt gatataaatg atgagaaaaa taattaaaat
    11341 tgatgaggaa aagtgtaatg gttgtggact atgtgttgaa gcttgtcatg aagaagctat
    11401 aggaatggta aatggaaaag caaaactttt aagagatgac tattgtgatg ggctgggaga
    11461 ttgtctgcca acttgtccaa caaatgcgat ttcatttgag tatagagaag cagcagaata
    11521 tgatgaagct gcagtaaaag caaatatgga agcaaagaaa gcacaaaaga aaactttagc
    11581 atgtggatgt ccaggttctc agtctaaatc aataaataga gaggtttcaa atagtacgtc
    11641 tataagcaat gatatagtag agataaaagg ttctcaactt aatcaatggc cagtacaaat
    11701 aaaattagta ccaactaatg catcatattt aaagaatgca agtcttttaa tagcagcaga
    11761 ctgtacagcg tatgcatatg gaaattttca taataaattt atgaaaaata aggttacatt
    11821 aatcggatgc cctaaacttg atgaagttga ctatgctgaa aaacttacag agattttaaa
    11881 agaaaatgat attaaaaata tagtagtaac acgtatggaa gttccttgct gtggtggtat
    11941 agtaaatgct gttaagacag ctctacaaaa tagtggaaaa atgataccat ggcaaatagt
    12001 tactatatct gtagatggaa aaattgtaga tggagaaatt taattaagtg aattatagaa
    12061 aaatataata aattttaata aataaaaagg gaggaataaa aaatggaaaa aatgttttgt
    12121 tttcaatgtg aacaaacagc aggaggtaaa ggttgtacta taaatggtgt ctgtggtaaa
    12181 aaggggggta cagctaactt acaagacgaa cttacaggag tgttgattgg tctttcaaga
    12241 gcaactattg gaaataagaa tagaccaaca agtgaaacag ataaaattat gatagagggg
    12301 ctattcacta ctataacgaa tgtaagtttt gatgatgaag ctataaaaag acaaattgaa
    12361 aaaactgagg tagaaaaaag taaacttgta cctagatgtt cagattgttc aacaacttgt
    12421 aatagaaatg ataactatga tatgaaggat ttatggaatg ataatgagga catacgttca
    12481 ttaaaatcat taatcttatt tggattaaga ggtatggctg cctatgcata tcatgcaatg
    12541 gtacttggtt atacagacaa agacgtaaat gaatttttct atgaaggatt aatagcagtt
    12601 ggaggagact tgtctattga cgaactttta ggtctagtta tgaaaactgg agaaataaac
    12661 ttaaaatgta tggaattgct tgatagagca aatactgaaa cttatggaac accagaaccg
    12721 actcaggtat ctatgaaaat cgagaaaggg ccatttattg tagttacagg acatgacctt
    12781 tatgatttac acaaattatt agaacaaacg aaagataagg gtataaatat atatactcat
    12841 ggtgagttat taccagcaca tgcatatcca aaactaaaag aatataaaca tctaaaaggc
    12901 aattttggta cagcatggca aaaccagcaa aaagaatttg ataatattcc tgctccaata
    12961 ttatttacaa caaactgttt aatgcctgtt aaagatagtt atagagatag agtatttact
    13021 acagaagtag ttgcttatcc aggtatggtt catattgatg aagataaaga tttttctagt
    13081 gtaatagaaa aagctcttga acttggagga tatagagaag atgttcatat gactggtatt
    13141 aatggaggag atacattaac tactggtttt gcaagaggta cagtttcatc tgtacaagat
    13201 aaagtagtag atgctgtaaa gagtggagct ataagacact ttttattggt tggaggttgt
    13261 gatggtgcaa aacctggaag aaattattac actgaatttg taaaacaagc tcctaaagac
    13321 actgttatat tgacacttgc atgtggaaaa tatagattta atgatttaga ccttggggat
    13381 ataggtggct tacctcgttt aatggatatg ggacaatgta atgatgctta tagtgcaatt
    13441 aaagtggcag tttcattggc aaatgctttt gaatgtggag taaatgattt gcctcttagc
    13501 atggtactgt catggtatga gcagaaagct gtttgtatac ttcttacact acttcattta
    13561 ggtatcaaaa atatctatat agggccttct ttaccagcat tcttatctaa gaatgtatta
    13621 gatatattgg ttgataaatt tgcattgaca cctatatcta ctcctgaaga agatatgaag
    13681 aagattttag gataaataaa tatatctata cttaaagata tttatagtta aaatattttt
    13741 aagtatgcca caattaagat aaggggttaa acttaaaatt tgattaaaaa atcaattttg
    13801 agatgaccct ttatttattt tttgtaataa ttgaaaaata aacctgcttt cagtatattc
    13861 ttttaagaat ttttgtatta aat
//
LOCUS       DAEQCW010000098        13830 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.099, whole genome shotgun sequence.
ACCESSION   DAEQCW010000098 DAEQCW010000000
VERSION     DAEQCW010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13830)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13830)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13830
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.099"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(5..883)
                     /gene="speB"
                     /locus_tag="KRO40_002857"
     CDS             complement(5..883)
                     /gene="speB"
                     /locus_tag="KRO40_002857"
                     /EC_number="3.5.3.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatinase"
                     /protein_id="HBH2093670.1"
                     /translation="MKNNFYHRNTFMSMNKNYEESNLIVFGVGFDGTTSNRPGARFAS
                     SSMRKEFYGLETYSPFLDLDLEDYNICDYGDLEISVGSTEQVLKEIYQETYKIVRDSK
                     VPFMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNNSKNSHATVIKRIWDI
                     VGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGIDTFENIVNMLNGKNIYLTIDLDV
                     LDAAVFPGTGTPEPGGVNYREFQEIFKIIKNSNINIVGCDIVELSPDYDTTGVSTVIA
                     CKILRELCLIISDKIK"
     gene            complement(873..1724)
                     /gene="speE"
                     /locus_tag="KRO40_002858"
     CDS             complement(873..1724)
                     /gene="speE"
                     /locus_tag="KRO40_002858"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HBH2093671.1"
                     /translation="MELWYTEEWTENVRFSIKVNKHLFEGKSQFQRIDVFDSDEFGKF
                     LTIDGLMMVTYKDEFIYHEMITHVPMATNLNIKKVLVIGGGDGGTVRELSCYPQIEKI
                     DMVEIDKMVVDVSKEYMDICSCKLDDKRVSLYFEDGVNFVKCAHDKSYDLIIVDSTDP
                     IGPGEGLFSTDFYKDCYRILTDDGILVNQSESPYFDFNAKEMKRANKKLKQIFPISEV
                     YQAHIPTYPSGHWLFGFASKKLNPVKNQDRNGWEKLSLKTKYYNSDIHLGSFMLPQYV
                     KEMLDEE"
     gene            complement(1754..2167)
                     /gene="speD"
                     /locus_tag="KRO40_002859"
     CDS             complement(1754..2167)
                     /gene="speD"
                     /locus_tag="KRO40_002859"
                     /EC_number="4.1.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylmethionine decarboxylase"
                     /protein_id="HBH2093672.1"
                     /translation="MKFETLGRHILVEYYNCDENVLKDPRLIENFMNDSALNAKATIV
                     DSVFHHFNPWGVSGAVIIAESHLTIHTWPEYGYAAADFFTCGDIDPWKSFELLEQLLK
                     SERSESTEIPRGLTTKIKKYSKKDLGKITHKPEAV"
     gene            complement(2254..3729)
                     /locus_tag="KRO40_002860"
     CDS             complement(2254..3729)
                     /locus_tag="KRO40_002860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH2093673.1"
                     /translation="MDSEFANAVELSYECAPLLESLKEYSEKDIACFDVPGHVKNRGV
                     AILNKYLGESLMKMDINSSPTMDNVSAPNGIIKNAQDLLAQAYMADEAFFITNGTTQA
                     IHAMILSVIKPGEKVLLPRNIHKSVINALILCGGIPIFIQPEFDEKLGISLNITLEKV
                     RTEIEKDCNIKALFFLNPTYYGVCADLESIIELCHKNNVLVLVDEAHGAHFPFHLDLP
                     PSAISLGADMVAVSIHKTGGALTQSSALLLNRDNVSFEKVLQSINMLQSTSASYLLMA
                     SIDGARVNLVENGEKQLSKALNLSRYAKSKLNKIDGIKVLSTEILKQKGVKFIDETKL
                     CINVKELNLTGFEVYDLLYKNFSIQVELGDSYNILALVSIGTNKSDIDRLVKALSIIA
                     KIYRKESTLNEFNMVQINPIIKLNPREAFYAPKESVEINSCIDRICGESIMAYPPGIP
                     IIAPGELITEEIMEYIIFLKNSNAYLTDVQDKNLDRILVIK"
     gene            complement(4367..5020)
                     /locus_tag="KRO40_002861"
     CDS             complement(4367..5020)
                     /locus_tag="KRO40_002861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093674.1"
                     /translation="MKVDPLTTQVYDYISKKIQNGEYEANQRITESEICKSIGVSRTP
                     AREALTRLAGENLLEKIPNKGFVVKEFQEKEKLDTYSVIGVLDALAGSSALQNLTESD
                     LVKMEELTEMMAVSIKYKNYNSYLKLSNEFHDIYITKSDNQVLVNLLNSLRYNFMSKS
                     YTSDNEDELYKMLTYSNNQHIEVVKSMRENDLENVERVLREHWKTIPIAEMKKEKLL"
     gene            complement(5265..7130)
                     /locus_tag="KRO40_002862"
     CDS             complement(5265..7130)
                     /locus_tag="KRO40_002862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="HBH2093675.1"
                     /translation="MQSVIEYNSWDKNFKAPFGALKFDEELTICVKVNEGYNIKSISL
                     EINREEEMRTITLNEELDNDKLGKCFCGKIEKFDGTGVYFYYFKVDVEMDGQIKTLFY
                     GKNRDNGYSCEYNYSDINKYQITVYKDFKVPTWYKEGILYHIFVDRFNNGNRSGKVDN
                     PKKNSFIYGNWEDTPMYIKDSQGDVIRWDFHGGNLRGIINKLGYLKKLGVSILYLSPI
                     FEASSNHKYDTGDYKKIDPMFGDEDTFKELIDKAKEKGISIVLDGVFSHTGADSKYFN
                     MYGNYNSLGAYQSKESPYYSWYMFEEFPQKYKSWWDVKTLPNINELEHSYMDYIIYDN
                     DSVINKWVNMGIKGWRLDVADELPTKFIRELKKELKKADDDSILIGEVWEDASNKISY
                     GQRRSYLLGEELDSVMGYPFRNNMFSFLKGEINSYELCNRYMQIKENYPKESFRSNLN
                     LIGTHDVTRAKTELNDDVDLVKLAVAIQMTFEGVPYIYYGDEAGLCGGVDPDNRRTYP
                     WKNEDEDMLNFYRDVIKIRNKNKLLSSGNTEFIYTNNDSVFSFIRVNENNDRMLILVN
                     RSENVESISLCIESSFIEEIPIKYSLKNANSTIQIENNELKVDLDSKSFRIFRVN"
     gene            complement(7135..9555)
                     /locus_tag="KRO40_002863"
     CDS             complement(7135..9555)
                     /locus_tag="KRO40_002863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HBH2093676.1"
                     /translation="MVTISKKKFKQKFEVKMYSLYAQSIKEATDEQLLNVLCSLLKDE
                     IAKKWVATKLDKKKEVYYFSLEFLIGRQLKSNLLNLNIEEEVREGLSELGINLDDLIE
                     AEVDPALGNGGLGRLAACFLDSMASLNISGQGYGIRYKYGLFEQKFVNGYQVEVPDNW
                     LTEGRYAWETVRPNEATMVKFGGEVELIKEGSHLKVIHKNYLPVMAMPYDIPIIGYQN
                     QCINTLRLFKSEIPKRDFGELTSNALNYSGSYEEALKHKYYTEEISQVLYPDDSNYAG
                     KLLRLKQEYFFVSAGIQDIIRKYKKNKLNINNLFDKVAIHINDTHPTLCIPELMRILL
                     DEENLSWDEAWEITKKTVSYTNHTIMSEAMEKWPVSMMKELLPRIYMIIEEINRRYVE
                     ELNNKGYDQDRIKRMSIIDCDNINMANLCIVTSHSVNGVAKLHTHILETEVLKDFYQD
                     EPNKFNNKTNGIAHRRWLISSNPQLSNLITDLIGDSWKKDTLQLKNIEKFKNDSSVLQ
                     RLDDIKYNNKANLAKFIKDKYDLNVDPSSIFDVQVKRLHAYKRQLLNIFNVLHMYHEL
                     LDNPNLNLDPRTFIFGAKAAPGYYLAKCIIKFINSVASTINNDVRVKDKLKVVFLENY
                     GVSLAEIIIPAANVSEQISTTTKEASGTSNMKFMMNGAITLATLDGANVEICEQVGKE
                     NMFLFGLSAEQVLNYNKYGGYSSLDLYHSNMDIKRVVDDLINGFIPNLGEEGRSIYNS
                     LTTYNDEYFVLRDFENYGQAQADINRLYRDKEKWNKMSLVNIANSGFFSSDRTISEYA
                     KDIWFKRV"
     gene            complement(9569..11011)
                     /gene="glgA"
                     /locus_tag="KRO40_002864"
     CDS             complement(9569..11011)
                     /gene="glgA"
                     /locus_tag="KRO40_002864"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011053260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HBH2093677.1"
                     /translation="MKVFYVTAECWPFAKTGGLGDVSYALPKELKKEGVDVRVIMPKY
                     STIPSYLKDQLKEIAVFSVRVGWRNQYCGLLEMELDGVKFYFIDNEFYFRREDERKSI
                     YGYGDDAERYTFFTDAVLEAISRIDFYPDVIHINDWHTGMLPLILKERYATLEGYKNI
                     KTMYTIHNLQYQGVFDKHVLYDILDLPQKYFDNGDIEYYGSINFMKAGINFADKIITV
                     SPTYANEIQTSFYGEQLDGLLRKESGKLKGILNGIDYDLNDPAKDKDIFVHYDVDSID
                     KKVENKLRLQDILGLKKDSSIPLIGIVSRLVSQKGFDLIAYMMPELMREDLQIVVLGT
                     GEHQYQSMFNYYDSNFSDKVSARITFNASLAQQIYAASDMFLMPSLFEPCGIGQMLAM
                     RYGSLPIVRETGGLRDTVTPYNKFTGEGNGFSFKNYNAHEMFFCLKNAIKVFKDKEKW
                     IKLVENAMKTDNSWKKSAKEYIETYRDICD"
     gene            complement(11040..12170)
                     /gene="glgD"
                     /locus_tag="KRO40_002865"
     CDS             complement(11040..12170)
                     /gene="glgD"
                     /locus_tag="KRO40_002865"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HBH2093678.1"
                     /translation="MRNECLGIINLNKKGDPAINKLNYGRPIASTPIAGRYRIIDFAL
                     SNMINSGITKVGIFAKEKYRSLTDHIGSGKDWDLSRKKGGLSIFSPENTKYRNTYSHR
                     EGDIYTILANLDYIEKSEEEYILIAPSYMLCNLNYSQALEYHKKSHNDITIIYKNVNN
                     ANKDFAGNLTLNLDSNNRVINVGNNLGKFPRANICMETYIMKREDFVECIYNIVNKGN
                     YCYLEEFIIEEAENMKIGAYEYTGYLKCVNSVESYFEMSKDLLNLEVADELLYSERKI
                     FTKEKNESPTIYTDSAKVENSFIASGCLIEGTVKDSIIFRKVNVEKGTVIENSIVMQN
                     CVIKSNAKLYNAILDKNTSVSNGKELRGDEKYPLVVEKNTNI"
     gene            complement(12172..13332)
                     /locus_tag="KRO40_002866"
     CDS             complement(12172..13332)
                     /locus_tag="KRO40_002866"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HBH2093679.1"
                     /translation="MKKEMLAMILAGGQGSRLGVFTKRIAKPAVSFGGKYRIIDFVLS
                     NCSNSGIDTVGVLTQYRPLILNSHIGMGSHWDLDRINGGVYVLQPFMNEKEGNWYNGT
                     AHAIYQNMDFVDTYNPEYVLILSGDHIYKMDYSKMLKFHKEKGSKATIAVIEVPWDEA
                     SRFGIMNTNEDSSIYEFEEKPSEPKSNLASMGVYIFDWKMLRNYFKEAEKNPEINYDD
                     FGKNLIPKMLEDNVGMYAYPFKGYWRDVGTIQSLWDANMDIIKSPETLDLADPKWKIY
                     TNTMAMPPQYIGKNANVHRSMIADGCRILGEVGNSVLSHGVVVGKGSKVIDSVIMPNV
                     VIGENVTIEKAMIGECATINDNVQIKNVNNEINVVSEYENIEPRCVLIEGGL"
BASE COUNT         4369 a         2471 c         1377 g         5613 t
ORIGIN      
        1 tactctattt aattttatca gatattatta agcataactc tcttaagatt ttacaagcta
       61 taactgtcga tacacctgtt gtatcgtaat cagggcttaa ctctacaatg tcacaaccaa
      121 ctatatttat attagagttt tttataatct taaaaatctc ttgaaactct ctataattta
      181 caccaccagg ttctggtgta cctgttcctg gaaacacagc tgcatccaat acatctaaat
      241 ctatagttag ataaatattc tttccattta gcatattaac tatattttca aacgtatcta
      301 ttcctcctat ttccatgtat gtgtgttttt cttctgtagc aaatttaaat tcttcttttg
      361 tcccagacct tataccaaat tgaaatattt tattatcacc tacaatatcc catattcttt
      421 taattactgt tgcatgagaa tttttactat tattatattc ttccctcaag tcagtatggg
      481 catcaaaatg aattacatat atatcattgt acttttcatg tactgcttta aaggctggta
      541 atgtaactaa atgctctcct ccaatcataa agggtacctt tgaatctcta acaatcttat
      601 atgtctcttg atagatttct tttaagactt gttctgtact tccaacacta atttctaaat
      661 ctccataatc acatatatta taatcctcta aatccaaatc taaaaaagga ctatatgtct
      721 caagaccgta aaattctttt ctcatagagc tacttgcaaa tctagcccca ggtctgttag
      781 aagtagttcc atcaaatcca acaccaaata ctataagatt agattcttca taatttttgt
      841 tcatactcat aaaagtgttc ctatgataga aattattctt catctagcat ctccttcacg
      901 tattgaggta acataaacga acctaaatgt atatcactat tataatattt agtttttaaa
      961 cttaatttct cccatccatt tctatcttga ttttttactg gattaagttt ttttgaagca
     1021 aatccaaaca accagtgacc agatggatat gttggtatat gtgcttgata aacttctgat
     1081 attggaaata tctgttttaa ctttttatta gctcttttca tctctttagc attaaagtca
     1141 aaatacggac tttcactttg atttactaaa attccatcat cagtcagtat tctataacaa
     1201 tccttataaa aatcagttga gaaaagccct tcgcctggtc ctattgggtc agttgaatct
     1261 actattatca ggtcatatga tttatcatgt gcacacttaa caaaattaac accatcttca
     1321 aaatataaac tcactctttt atcatctaat ttacatgagc atatatccat atactcctta
     1381 gatacatcta caaccatttt atctatttca accatgtcaa tcttttctat ttgaggataa
     1441 cagcttaatt ctcttactgt acctccatca cctccaccta tgactaatac tttctttatg
     1501 tttaaatttg tagccatagg aacatgagtt atcatctcat ggtatataaa ttcatcttta
     1561 tatgttacca tcattaatcc atctattgtt agaaattttc caaattcatc actatcaaat
     1621 acatctatcc tttgaaattg agactttcct tcaaatagat gtttatttac ttttatagaa
     1681 aatcttacat tttctgtcca ttcttctgta taccaaagtt ccatataata atcctcactt
     1741 tctcttgtat gttttatact gcttctggtt tatgagtaat cttacctaaa tctttttttg
     1801 aatatttttt aatttttgta gttaagcctc ttggaatttc tgtagactcg cttctttcag
     1861 actttaaaag ttgctctaat aattcaaaac ttttccatgg gtctatatca ccacaagtaa
     1921 aaaaatccgc tgctgcataa ccatattcag gccatgtatg tattgtcaaa tgagattcag
     1981 caattataac agctcctgaa accccccaag gattaaaatg gtggaataca gaatccacaa
     2041 ttgtcgcttt tgcatttaat gctgaatcat tcataaaatt ttctataaga cgtgggtctt
     2101 taagtacgtt ttcatcacaa ttatagtatt ctactagtat atgtcttcct agtgtttcaa
     2161 atttcatttc aaccccaact cctttatact tttaataagt tctatttgat aaactctact
     2221 taacaaatac ttgcccttgc aaaataaagt aatttatttt attactaata ttctatctaa
     2281 gtttttatct tgtacatctg taagatatgc attgctattt tttaagaaaa taatatactc
     2341 cataatttct tctgttatca attctcctgg agcaataatc ggtatacctg gtggatatgc
     2401 cattattgat tctccacaaa ttctatctat acatgaattg atttctacac tttcctttgg
     2461 tgcataaaaa gcttctcttg gattaagttt aataattgga tttatttgaa ccatattaaa
     2521 ttcatttaat gttgattctt ttctataaat ctttgcaatt atagaaagtg cttttactaa
     2581 tctatctata tctgatttat ttgttccaat ggacacaagt gccagtatat tatatgaatc
     2641 tcccaattct acttgaattg aaaaattttt atataataaa tcgtatactt caaatccagt
     2701 caaatttaat tcttttacat ttatacacaa ttttgtttca tctataaatt taacaccttt
     2761 ttgtttcaat atttctgtag ataaaacttt tattccatca attttgttta atttagattt
     2821 tgcataccta gatagattta atgcttttga cagttgcttt tcaccattct caactagatt
     2881 aactctagca ccatctatac ttgccataag caaataagat gctgatgttg attgtagcat
     2941 attgattgat tgaagaacct tttcaaaact tacattatct ctattcaata agagtgctga
     3001 agattgtgtc aatgctcctc cagttttatg tatacttaca gctaccatat cagctcccaa
     3061 acttattgca gaaggaggta aatctaaatg aaatggaaaa tgtgcaccat gagcttcatc
     3121 aactaacact aaaacattat ttttatggca tagttctata atactctcaa ggtctgcaca
     3181 aactccatag taagttggat taaggaaaaa taatgctttt atattacaat ctttttctat
     3241 ctctgttcta actttttcaa gagtaatatt taaacttata cctagttttt catcaaattc
     3301 tggttgtata aatattggta ttcctccaca aagtattaac gcatttatta ctgatttatg
     3361 tatatttctt ggaagtaata ctttttcacc tggttttata acactcaaaa tcattgcatg
     3421 tattgcttga gttgtgccat tcgttataaa gaatgcctca tcagccatat atgcttgtgc
     3481 tagcaaatct tgtgcatttt ttataatccc atttggcgca gatacattat ccatagttgg
     3541 tgatgaattt atatccattt tcatgagact ttcacctaga tatttattta atatagctac
     3601 acctctattt tttacatgtc caggcacatc aaaacaagct atatctttct ctgagtattc
     3661 ctttaacgac tctaataatg gagcacactc atagcttaat tcaactgcat ttgcaaactc
     3721 gctatccatg atttcaaatt catctcctct ctatattcaa atatttttaa tatttattat
     3781 ttattatttc tattttttat ttttactttt attaaactca tgatatttat tatattaaca
     3841 tctcagcatt tttacaagtg tttttttgaa gttactcaaa aacatataca ttagctatat
     3901 caatatttat aaacttttta attttttgtt gtttatatta atttttttaa aacttagtat
     3961 ttataaactt tcttattttt tattattttg gtttttttac ttttttgagt tttagtaagc
     4021 ttttgagttt actattttta atttataagt attttattac taaactttta tattattctt
     4081 atttcacata ttaaaattct tggtttagtt ggactaaata attttcctat ttttgtattt
     4141 taattttaat ataaaattta ttaaattttt taattgataa aataaattct atatttatga
     4201 tattaaaatt ctataagttc attgatttat atatgttaat ttaaatacat tattctatcg
     4261 tagtgcctta gagtttttat ttgtatttaa agttaaattt attcttgttt ttcctttaat
     4321 atttaatagt aaaacaacaa aattataaaa aaaataaaga gaaactttat aaaagcttct
     4381 cttttttcat ctctgctata ggtatcgttt tccaatgttc tctcaaaact ctttcaacat
     4441 tttctaaatc attctccctc atagatttta ctacttcaat atgttgatta ttgctgtatg
     4501 tcaacatttt atataactca tcttcattat cactagtata tgactttgac ataaaattat
     4561 atcttaaaga gttcaataga tttactaaca cctgattatc tgatttagtt atgtatatat
     4621 cgtgaaattc attacttaat tttaaatagc tattgtaatt tttatacttt atagagaccg
     4681 ccatcatttc cgttaattct tccattttta ctaggtctga ttcagttaaa ttttgtaatg
     4741 ctgaagaacc ggctaacgca tccaatactc caattacgga ataggtgtct aatttctcct
     4801 tttcctgaaa ttcttttact acaaatccct tattaggtat tttttctagt aaattttcac
     4861 ctgctaacct agttaatgct tctctcgctg gtgttctact aactccgata gatttacaaa
     4921 tctcagattc agtaattctc tgattagctt catactctcc attttggatt ttctttgata
     4981 tatagtcata tacttgagtt gtaagtggat ctaccttcat aagacgttcc tccatattaa
     5041 gattataaaa gttaaatctc cctacaactt tggtagagag ttcagtttta tcttactaat
     5101 ttatataata tcacaattat gatatttttt atacttcttt gtaatatttt gaaatactaa
     5161 aattcttatg ataatttata caaaaaaagt agaaaaagtt ttgataaaac aaaactcttt
     5221 ccacattcac cttattttct atttattttt ctaaaaaaag atatttaatt tactctaaaa
     5281 attctaaatg atttagagtc taaatctact ttcaactcat tattttcaat ttgtatagta
     5341 ctatttgcat ttttaagact atactttata ggtatttcct caataaaact actctctata
     5401 cataatgata tactttccac attttcactt ctatttacta aaattaacat tctatcatta
     5461 ttttcattaa ctctaataaa agaaaataca gaatcattat tagtatatat aaattctgta
     5521 tttccagaac ttaaaagttt attcttattt ctaattttta taacatctct ataaaaatta
     5581 agcatatctt cgtcttcatt tttccatgga taagttcttc tattatctgg gtcaacacct
     5641 ccacaaagac ctgcttcatc tccataatat atatatggta ctccttcaaa tgtcatctgt
     5701 atagctacag caagcttcac taaatctaca tcatcattta attccgtttt agctcttgta
     5761 acatcatgtg ttccaattaa atttaaatta gacctaaatg attcttttgg ataattttct
     5821 ttaatctgca tatatctatt acaaagttca tatgaattaa tttctccttt taagaaagaa
     5881 aacatgttat ttctaaaagg ataacccata acagaatcta attcttcacc taataaataa
     5941 cttcttctct gaccatagct aatcttattt gatgcatctt cccatacttc acctataaga
     6001 attgagtcat catctgcctt ttttaattcc ttttttaact ctcttataaa cttagttggt
     6061 aattcgtctg caacatctag tctccagccc ttaataccca tatttaccca tttatttata
     6121 acgctatcat tgtcatatat tatataatcc atatagctat gttctaattc atttatattt
     6181 ggcaatgtct taacatccca ccaactttta tatttttgag gaaattcttc aaacatatac
     6241 catgaataat atggagattc tttagattga tatgccccta aactattata gtttccatac
     6301 atattaaaat atttactatc tgctccagta tgactaaaaa ctccatctaa tactattgat
     6361 ataccttttt cttttgcttt atcaataagt tctttaaatg tatcttcatc tccaaacatt
     6421 gggtcaattt ttttatagtc acctgtatca tacttatgat tactagaggc ttcaaatata
     6481 gggcttagat atagtatact tacacctaat ttttttaaat atccaagttt attgattatc
     6541 cctcttaaat ttccaccatg gaaatcccat cttataacat ccccttgact atcctttatg
     6601 tacataggtg tatcttccca atttccatat atgaaactat tttttttagg attatcaacc
     6661 ttaccactac gatttccatt attgaatcta tctacaaata tatgataaag tattccttct
     6721 ttgtaccatg ttggtacttt aaaatctttg taaacagtga tttgatattt attaatatca
     6781 ctataattat attcacaaga atatccatta tctctgtttt ttccataaaa taaagtcttt
     6841 atctgaccat ccatttcaac atcaacttta aagtaataaa aataaacacc tgtaccatca
     6901 aacttttcaa tcttaccaca aaagcacttt ccaagtttat cattatctaa ttcttcattt
     6961 aaagttattg ttctcatttc ttcttctcta tttatttcta gggaaataga cttgatattg
     7021 tatccctcat ttactttaac acaaatggtc aattcctcat caaattttaa agctccaaac
     7081 ggagccttaa aatttttatc ccaagagtta tattctatta cactttgcat ttaatcacac
     7141 ccttttaaac caaatgtctt ttgcatactc agaaattgtt ctatcagaag aaaaaaatcc
     7201 agagttagct atattaacta aagacatttt attccatttt tctttatctc tatataacct
     7261 gtttatatct gcttgagctt gaccataatt ttcaaaatct ctcaatacaa aatactcatc
     7321 attgtaagta gtgagtgaat tataaatact tcttccttct tcgccaagat taggaataaa
     7381 tccatttatt aaatcatcta ctaccctttt tatatccata ttagaatggt ataggtcaag
     7441 tgaagaatat ccaccatatt tattataatt tagtacttgt tctgcactaa gtccaaataa
     7501 aaacatattt tctttaccaa cctgttcaca tatctctaca tttgcaccgt caagtgtagc
     7561 caaagttata gcaccattca tcataaactt catattactt gttccagatg cttccttagt
     7621 tgtagttgaa atttgctcac taacatttgc tgctggtatt attatttctg ctaatgatac
     7681 tccataattc tctaaaaata ctacttttaa cttgtccttt actctaacat cattatttat
     7741 agtacttgca acagaattta taaatttaat tatacattta gccaaataat atcctggtgc
     7801 tgcttttgcg ccaaatataa aagttcttgg gtcaagattc aaattaggat tatcaagtaa
     7861 ttcatgatac atatgaagta cattaaatat attcagtaac tgtcttttat acgcatgcaa
     7921 tctcttaact tgaacatcaa atatcgaact tgggtctaca tttaaatcgt atttatcttt
     7981 tataaacttt gctagatttg ctttattatt gtattttata tcatcaagtc tttgtaaaac
     8041 agaggaatca tttttaaatt tttcaatatt ttttaattgt aatgtatctt tcttccatga
     8101 atcaccaatt aaatctgtaa ttaaattgct aagttgagga tttgaactta taagccatcg
     8161 cctatgtgca attccattag tcttattatt aaatttattt ggttcatctt gatagaaatc
     8221 ttttaatacc tctgtttcaa gaatatgagt atgaagctta gcaactccat ttacactatg
     8281 acttgtgaca atacataagt ttgccatatt gatattgtca cagtctatta tactcattct
     8341 ttttattcta tcttggtcat atcctttatt atttaattcc tctacatatc ttctatttat
     8401 ttcttctatt atcatataaa ttcttggtaa tagttctttc atcatactta caggccattt
     8461 ttccattgct tctgacatta tagtatgatt agtataggac actgtttttt tagttatttc
     8521 ccatgcttca tcccaagata aattttcttc atcaagcaaa attctcataa gttctggtat
     8581 gcataaggta ggatgtgtat catttatatg aattgctacc ttatcgaata aattattaat
     8641 atttaatttg ttctttttat attttcttat tatatcttgt atccctgcac ttacaaaaaa
     8701 gtattcttgt ttcaacctca acaacttacc tgcatagttt gaatcatcag gatataatac
     8761 ctgtgatatt tcctcagtat aatacttatg ttttaaagcc tcttcatagc taccagaata
     8821 atttagagca tttgaggtaa gttcaccaaa atctctcttt ggtatttcac tcttaaacaa
     8881 tcttaaagta tttatacatt ggttttggta tccgattatt ggtatatcat aaggcattgc
     8941 cattacagga aggtagtttt tatgaattac ttttaaatga ctaccttcct tgattaattc
     9001 tacctcacca ccaaacttca ccattgttgc ttcatttggt cttacagttt cccatgcata
     9061 tcgtccttct gtaagccagt tatcaggcac ttctacctga taaccattta caaatttttg
     9121 ttcaaacaga ccatatttat accttattcc atatccttga ccacttatgt tcaaagatgc
     9181 catagaatct aaaaagcaag ctgctaatct accaagtcca ccatttccta aggctgggtc
     9241 tacttcagct tcaattaaat catccaagtt gattcctaat tcagataaac cttctctaac
     9301 ttcttcttca atatttaaat ttaataaatt agattttaac tgtctcccta ttaaaaattc
     9361 taaactaaaa taataaactt cttttttctt atctaacttt gtagcaaccc atttttttgc
     9421 tatctcatct ttcaatagac tacataatac atttaacaat tgttcatcag tagcttcctt
     9481 gatagattgt gcatataagc tatacatttt tacttcaaat ttttgcttga atttcttttt
     9541 gcttattgtt accaaaaaaa ccactccttt aatcacatat gtctctatat gtttctatat
     9601 actccttagc tgattttttc caactattat ctgttttcat tgcattttca actaatttaa
     9661 tccatttttc tttgtcctta aatactttga ttgcattttt caaacagaaa aacatctcat
     9721 gagcattgta atttttaaaa ctaaatccat tgccttctcc agtaaattta ttataaggtg
     9781 ttactgtatc tctaagccct ccagtctctc taactattgg taaagaacca tatctcatag
     9841 ctaacatttg acctatacca caaggctcaa ataatgatgg cattaagaac atatcacttg
     9901 cagcatatat ctgttgagcc aatgatgcat taaaagtaat tctagctgat actttatctg
     9961 aaaaattaga atcgtaatag ttgaacattg attgatattg atgttctcca gttcctaaaa
    10021 cgacaatctg taaatcttct ctcataagtt ctggcatcat gtatgctatt aaatcaaatc
    10081 ctttttgaga aactaatctc gaaactatac ctatcaacgg aatagatgaa tcttttttaa
    10141 gtcccaatat atcttgtaat ctcaatttat tttctacttt tttgtcaatt gagtctacat
    10201 cataatgaac aaatatatct ttatcttttg cagggtcatt taaatcataa tctataccat
    10261 ttaatatacc ttttaatttt cctgactctt ttctaagtaa tccatctaat tgttcaccat
    10321 aaaaagatgt ttgtatttca tttgcataag taggactaac agttataatt ttatctgcaa
    10381 aatttatacc agctttcata aaatttattg agccataata ctctatatct ccattatcaa
    10441 agtatttttg tggtaaatcc aatatatcat ataaaacatg cttatcaaat acaccttgat
    10501 attggagatt atgtatagta tacatagttt ttatattttt atacccctca agggttgcat
    10561 atctttcttt tagaattaat ggtaacatcc ctgtatgcca atcatttata tgtattacat
    10621 ctggataaaa atcaattcta cttatagctt ctaaaactgc atctgtaaag aaagtatatc
    10681 tttctgcatc atctccatat ccatagatac tctttctttc atcttctctt ctaaaataaa
    10741 attcattatc tataaagtaa aattttacac catccaattc catttctaaa agaccacagt
    10801 attgatttct ccatccaaca cgtacactaa acacagctat ttcttttagt tgatctttta
    10861 aataacttgg tatagttgaa tatttgggca ttattaccct tacatctaca ccttcttttt
    10921 ttaattcttt aggcaatgca taagaaacat ctcctaatcc tccagttttt gcaaagggcc
    10981 aacactctgc tgttacataa aaaaccttca ttagtcattc ccccttctaa aaaatttatt
    11041 tatatatttg tattcttttc cactacaaga ggatattttt catctcctct taattctttc
    11101 ccatttgata cactcgtatt tttatctaat attgcattat atagttttgc atttgacttt
    11161 attacacaat tttgcattac tattgagttc tctataactg ttcctttttc aacatttacc
    11221 tttctaaata tgatactatc ttttacagta ccttctatta aacaaccaga tgctataaag
    11281 ctattttcta ctttagcact atctgtataa attgtaggtg attcattctt ttcttttgta
    11341 aatatctttc tttcagaata taataattca tctgcaactt ctaaatttaa taaatctttg
    11401 ctcatttcaa aatatgattc aacagaattt acacatttta gatatcctgt atattcatag
    11461 gctcctattt tcatgttttc tgcttcttca ataataaatt cttctaaata acaataattg
    11521 cctttattta caatgttata tatacattca acaaaatctt cacgcttcat aatatatgtc
    11581 tccatacata tgtttgctct agggaactta cctaaattat ttcctacatt tattacccta
    11641 ttgttactat ctaaatttag agttaagtta ccagcaaaat ctttatttgc attatttaca
    11701 tttttatata ttatagttat atcattatga gattttttat ggtattccaa tgcttgagaa
    11761 taatttaaat tgcatagcat atagcttgga gctattaaaa tatattcttc ttcactcttt
    11821 tctatataat ctagattagc taagatagta tatatatcac cttctctatg tgagtaagta
    11881 tttctatact tagtgttttc tggactaaaa attgataggc cacctttttt tctacttaaa
    11941 tcccaatctt taccactacc tatatggtct gttaatgatc tgtatttttc ttttgcgaat
    12001 attccaactt tagtgattcc tgaatttatc atattagata aagcaaagtc tattattcta
    12061 tatcttccag ctattggtgt agatgctatt ggtcttccat agttaagttt gtttattgct
    12121 gggtctcctt ttttgtttaa atttattatc cctaaacatt catttctcat cttaaagacc
    12181 tccttctatt aatacgcatc taggttcgat attttcatac tcagaaacta catttatttc
    12241 attatttaca ttctttatct gaacattatc atttatagtt gcacactcac ctatcatagc
    12301 tttttctata gttacatttt cacctattac aacatttggc attattactg aatcaattac
    12361 tttacttcct ttaccaacaa caactccatg tgataataca gagttaccta cttcacctaa
    12421 aattctacaa ccatcagcta tcattgatct atgaacattt gcatttttac ctatatattg
    12481 tggaggcatt gccatagtat ttgtatatat cttccactta gggtctgcta aatcaagtgt
    12541 ttctggagat tttattatat ccatattagc atcccataga ctttgtatag ttcctacatc
    12601 tctccagtat cctttaaatg gataagcata cattccaaca ttatcttcta acattttagg
    12661 tattaaattt tttccaaaat catcataatt tatttctgga tttttttctg cttccttaaa
    12721 ataatttctc aacattttcc aatcaaatat gtatactccc atagatgcca aattgctctt
    12781 aggttcactt ggtttttctt caaattcata gatacttgaa tcttcatttg tattcattat
    12841 cccaaatctt gaagcttcat cccaaggaac ttcaatcact gctattgtag ctttagagcc
    12901 tttttcctta tgaaatttta acattttgct ataatccatc ttgtatatat ggtcaccaga
    12961 taatatcaat acatattctg gattataggt atctacaaag tccatatttt gatatatcgc
    13021 atgtgctgta ccattatacc aatttccttc tttttcattc ataaatggtt gtaaaacata
    13081 gacaccacca tttattctgt ccaaatccca atgacttccc atgcctatat gtgaatttaa
    13141 tatcaacggt ctatattgag ttaaaacacc tacagtatca ataccagagt ttgaacaatt
    13201 gcttaacaca aaatctataa ttctatactt acctccaaat gatacagctg gtttggcaat
    13261 tctttttgta aaaacaccta atcttgaacc ttgccctcct gccaaaatca tagctaacat
    13321 ctcttttttc atttaatgac actcccctca tctagtaatt aatatttata attgcatttt
    13381 tacttttata aactttatca gtcaataaat gtcgtgtata aatgttgctt aaataatacc
    13441 ttaataaaaa taaaataata tcaactatac aattgatata atgtataccc cataatggac
    13501 ttaccgacgt atacattatt ttccataagc actatagtat ttattaatat tcaattatcg
    13561 gttaaaaaat aatacaaatt ttattttata aatataaaaa cattttttat aaatcttttg
    13621 tgtcatataa acatgcttat tttttaattt gttaaattcg taatagcaaa atataatcta
    13681 atatttgtta aataattatc caaagaaaat caagtaatta ttaatcaact ttatttttta
    13741 attgatactt ctttgtctat aatttaaaca aaaggatata aacttttaaa ttatttatta
    13801 gttttcttag tattaatgtt tatattttta
//
LOCUS       DAEQCW010000099        13208 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.100, whole genome shotgun sequence.
ACCESSION   DAEQCW010000099 DAEQCW010000000
VERSION     DAEQCW010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13208)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13208)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13208
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.100"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            134..1993
                     /locus_tag="KRO40_002867"
     CDS             134..1993
                     /locus_tag="KRO40_002867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093680.1"
                     /translation="MKRFLRRIILVLFILLIFISFISIKLIHNVGDYGKLINYVGIVR
                     GASQRLTKLEMNHQPNDELIEYIDEILQELITGHGDYGLVITDCNEYNEDLLLLEKKW
                     EDLNIEIKKVRMKEQNNQLLSISEEFFSLANDTVFKIENFSKEKSNYLMTLIIIISII
                     GILACIILILQYSKKMVRLEKLNVDLKNIAYKDELTGVNTIEKFKLDANQNICIHKDK
                     KFAVFYIDFENFKYINDIFGYDYGDMILKRYANLMMNDIGKYEIFAREIADRFVALRC
                     YVDKEDLVVRQRDVDNELINITNEIKNKHSITVVSGICCIEDVNEKLSIDGLINRANF
                     AQKTVKNKPGTNYAFYNDSIRKKMIEENTIKSRIHEAIEKREFIVYLQPKVNLHSQKI
                     NCAEALVRWLTPDKGIISPAIFIPVLEKNFFIALVDKYVFEEVCKWIRKRLDENKPFV
                     QISVNVSRIQFYNTKFVETYSNIQNKYRIPKNTIEIEFTESVAFENQKHLLEIIHDLH
                     ENGFTCSLDDFGKGYSSLSVLKDLPFDVLKLDSMFFKASLDKDKEKIVIKNIVHMLKE
                     LNITTVAEGIECKEQVEFLRDIGCDLVQGFVFYKPMPILEFEKILDKEFVYNS"
     gene            complement(2285..2884)
                     /locus_tag="KRO40_002868"
     CDS             complement(2285..2884)
                     /locus_tag="KRO40_002868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2093681.1"
                     /translation="MAIELKKGQKINLTKKENSDLGEILVNLNWNQKVQKKGFFGSLR
                     SSNIDLDLGCLFEMKNGVKGAVQALGNAFGSLDNPPFAQLDGDDRTGSNTQGENLRIN
                     GNKIKDIKRILIYAFIYEGVANWSEADGIVTIKQKQDSDLVVKLDEHKNGYNMCSIAL
                     IENVNDETFSVEKVVKYFKGHREMDTEFHWGLKWVAGRK"
     gene            complement(2987..3784)
                     /locus_tag="KRO40_002869"
     CDS             complement(2987..3784)
                     /locus_tag="KRO40_002869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2093682.1"
                     /translation="MKFKKLLCLLLCLVLTLAVVGCSKAKDDKKIVVGATLVPGGELL
                     EELKPLIKEKGYTLEVKNFDDYILPNEALNNGEIDANLFQHEPYLKEAVKAKGYKIMA
                     GKKLYVCPAILYSYKIKSVDEFKKGDTIAISNNPSSCSKNLRYLESIGLLTLPKGDGL
                     VSPKDIIENPKGIQFKELDIAQIPSSLPDVTAAFIDTTYAVPAGLDAKKNGIYTAPIN
                     DEYANLLAFRTEDKDSEKIKVLQDVLTSDKARSLIEEKYKGIVIPTF"
     regulatory      complement(3897..4003)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            complement(4095..5081)
                     /locus_tag="KRO40_002870"
     CDS             complement(4095..5081)
                     /locus_tag="KRO40_002870"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBH2093683.1"
                     /translation="MLLIYNEKTNPYFNLAMEEYLLKNFDEDLFILWRNEPSIIVGKN
                     QNTLSEINLEYIKEYSIPVVRRQSGGGAVFHDLGNINFTFIACNNNNFSDFRRFTQPI
                     IDLLKTLDVNAEFSGRNDLLIDGKKFSGNAQYNYKNKVMHHGTLLFSSEINDLSKALK
                     VKPIKFEGKGIKSVKSRVTNISEHLHSKMDILEFKDAIMDYLSKTNTDNTNYCLSEHD
                     IKQIEKLTKSKYETWDWNFGNSPKYTLSNELKYSGGNVEFNLNVDKGIITSIKFFGDF
                     FGKCDVAFVENKLIGIRHEENALRNTLDSIEINDYFLGADTDILVSGILGVK"
     gene            5565..7295
                     /locus_tag="KRO40_002871"
     CDS             5565..7295
                     /locus_tag="KRO40_002871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC family protein"
                     /protein_id="HBH2093684.1"
                     /translation="MRNKKINIIFLTTIMFIMSTVMVFAEEDIDTIALANAEKFGILT
                     LIPPLVAIILAFITKNVIISLLIGILSGSFIIKASGINVFATFIQAFLDLVDRALVSL
                     ADPWNAGIILQVLAIGGVINLVAKMGGAKAIAEALAKRAKSAKGTQLITWFLGLLVFF
                     DDYANSLIVGPMMRPVADKMKISREKLAFIIDATAAPVAGLAIISTWIGLEVGLIHDA
                     FESISIDVDAFGIFLNTIPFRFYNILILAFIVISALLLKEFGPMRKAEIKSRSRKISI
                     DLDEGVEELDDLAPKNGVKLSVWNAIIPIGTLIIVALASFYYSGYTSIMGGDDKALIQ
                     LFTNSPYSFEAIKEAFSASDASRALFQSALVASLVAIIMAVVKKIFTISEAIDVWIDG
                     MKSLVITGVILILAWSLSSVIKELGTAKFLIHLLSGSLPPFLLPSLIFGLGAIISFAT
                     GTAYGTMGILMPLAIPLAYSLNPDMSYVIVSTSAVLTGAIFGDHCSPISDTTILSSMG
                     AGCNHIDHVNTQMPYAIFTAVITIVFGYIPAGLGLPIYIVLPVAIAAIFVGIQIIGKK
                     VDEAEIELVE"
     gene            7405..7485
                     /locus_tag="KRO40_002872"
     tRNA            7405..7485
                     /locus_tag="KRO40_002872"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:7439..7441,aa:Leu,seq:tag)
     gene            7820..8335
                     /locus_tag="KRO40_002873"
     CDS             7820..8335
                     /locus_tag="KRO40_002873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HXXEE domain-containing protein"
                     /protein_id="HBH2093685.1"
                     /translation="MEKYIWLFPLLFIFHDMEEIIGFGIWLKKNKSMLDKKYPFISKV
                     YENYSTEGMAFAVFEEFILCIIFCILTVITENQYVYLLWLGSFIAYTLHLVIHIGQSI
                     IIRKYIPSLITSIICLPISIWCISKSIYIVDCEMSTTILYSIIGIIIVALNLKFAQSL
                     IGKFTKWMSNI"
     regulatory      8827..8931
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            9141..11615
                     /gene="gcvPA"
                     /locus_tag="KRO40_002874"
     CDS             9141..11615
                     /gene="gcvPA"
                     /locus_tag="KRO40_002874"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPA"
                     /protein_id="HBH2093686.1"
                     /translation="MNELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRK
                     SAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKINDIIYTPMCYENGGVVDDLLI
                     YKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQK
                     ITDIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVG
                     GEDICPAGLGCRDTLRFEAALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSK
                     EKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSE
                     YAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKKDNIILNKENKFSYIPATSEDKSKML
                     KVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLG
                     AGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANA
                     SMYDGATAAIEACIMAMNQTRKSKIVVSKTIHPETLSVLRTYLQYKDCEIVEIDFCNE
                     YGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSVDPISLG
                     VLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGK
                     IAYVLTLQTREQHVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAH
                     YTYNKLVQTGKYKPIFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELK
                     NSTLLCVTEKRSKEEIDKLVGIMEGL"
     gene            11615..13072
                     /gene="gcvPB"
                     /locus_tag="KRO40_002875"
     CDS             11615..13072
                     /gene="gcvPB"
                     /locus_tag="KRO40_002875"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPB"
                     /protein_id="HBH2093687.1"
                     /translation="MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDPDMARQSE
                     LNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHP
                     YQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
                     KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNP
                     STLGLFEKNIKEIATLVHEAGGLLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFST
                     PHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLV
                     RAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEA
                     NIKTIDIAKRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEA
                     KEEPELLKTAPHNTLVKRVDDARAVKKPILTWSQR"
BASE COUNT         4954 a         1574 c         2177 g         4503 t
ORIGIN      
        1 aactatgtaa aacaaggttt atatattcta attgtataga aaaatttatt gtaaacgcat
       61 gtatattatt agaaaaaata gtttggaggt attcaataaa cataaaaaac aatatagggg
      121 ataaaggtgt tttatgaaga gatttttgag gagaattatc ttagttttat ttattttgtt
      181 gatttttata agttttattt ctattaaatt aattcataat gttggagatt atggaaaatt
      241 gattaattat gttgggattg ttcgtggagc tagccaacgt ctaactaaac tagagatgaa
      301 tcatcaacca aatgatgaat taatagaata tattgatgaa atcctacagg agttgattac
      361 agggcatgga gattatggtt tagtaatcac tgattgtaat gaatacaatg aggacttact
      421 tttattagaa aaaaagtggg aagatttaaa tattgaaatt aaaaaagtaa gaatgaaaga
      481 acagaataac cagttattaa gtataagtga agagtttttt tctcttgcaa atgatacagt
      541 gtttaaaata gaaaactttt ctaaagaaaa aagtaattac ttaatgactt taataataat
      601 tatatctatt ataggtatat tagcatgtat catattgatt ttacaatata gtaaaaaaat
      661 ggttagactg gaaaaattaa atgtagattt aaaaaatatt gcatataaag atgaactaac
      721 aggagtaaat actatagaaa aatttaaatt ggatgcaaat caaaatattt gtatacataa
      781 ggataagaaa tttgctgtat tctatattga ttttgaaaac tttaaataca ttaatgatat
      841 atttggatat gattatggtg acatgatact gaaaagatat gctaatctta tgatgaatga
      901 catagggaaa tatgaaatat ttgcaagaga aattgcagat agatttgttg cgttaagatg
      961 ctatgtagat aaggaagatt tagtggtaag acaacgagat gtagacaatg aactaattaa
     1021 tataacaaat gaaattaaaa ataaacatag tattactgtt gttagtggaa tttgttgtat
     1081 tgaagatgta aatgaaaaat taagtataga tggtttaata aatagagcaa attttgcaca
     1141 aaaaactgtt aagaataaac caggtactaa ttatgctttt tataatgaca gtattcgtaa
     1201 aaaaatgatt gaagaaaata ctatcaaaag tagaatacat gaagctattg aaaaaagaga
     1261 atttatagtt tatttacagc ctaaagttaa tttacatagt caaaaaataa attgtgcaga
     1321 agctttagtt cgttggctta ctccggataa aggtattata tctccagcaa tatttattcc
     1381 agtacttgag aagaattttt ttattgcctt agtagataag tatgtttttg aggaggtttg
     1441 taaatggatt agaaagaggt tagatgaaaa taaacctttt gttcagatat cagttaatgt
     1501 ttcaagaata caattttata acactaaatt tgtagaaact tattccaata tacaaaataa
     1561 atacaggata cctaaaaata ctatagaaat tgaatttaca gagagtgttg cttttgagaa
     1621 tcaaaaacat cttttggaaa ttatacatga tttgcatgaa aatggattta cttgttcttt
     1681 agatgatttt ggaaaaggtt attcgtcttt aagtgtttta aaagatttac catttgatgt
     1741 tttaaagctt gattctatgt ttttcaaggc tagtttagat aaagataaag agaaaatagt
     1801 aataaaaaat attgtacata tgttaaaaga acttaatatc acaactgttg ctgaaggcat
     1861 tgaatgcaag gaacaagttg aatttcttag ggatattggg tgtgatttag ttcagggatt
     1921 tgtattttat aaaccaatgc caatattaga atttgaaaaa atattggata aagagtttgt
     1981 ttataatagc taaaatgtac tttataaaat atgaactaat taagtaaaat tattttgtac
     2041 tgaataaatt tttactttat ttacagaata atgattattt acagaaaagc gcgaaaagtg
     2101 tattccttta agtgtgggat ggatagcaca aataggggag aaaaaatatt ggccatataa
     2161 gaatgcataa taatataaat atttgaaagg tcagcattat ataaaaatta aaaagaaaat
     2221 aaataatttt tctataaaaa agagactatg agaaaattta ctcatagtct cctaaataat
     2281 gtatttattt tcttcctgca acccatttta atccccaatg aaattcagta tccatttctc
     2341 tatgaccttt gaagtattta actacttttt caacactgaa tgtctcatca tttacatttt
     2401 ctatcaatgc tattgaacac atattatagc catttttatg ttcatcaagt ttgacaacta
     2461 agtctgaatc ttgtttttgt ttgattgtta caattccatc agcttcagac cagttagcta
     2521 caccttcgta tataaaagca taaataagta ttctttttat atcttttatt ttattaccat
     2581 ttattcttaa attttctcct tgtgtattac ttcctgttct gtcatctcca tctaattgag
     2641 caaaaggtgg attgtctaaa ctaccaaagg catttcctaa tgcttgaaca gcacctttta
     2701 caccattttt catctcaaat aggcaaccca aatctaaatc tatattactg cttcttaaag
     2761 agccaaaaaa accctttttt tgtacttttt gattccaatt taaattaact aagatttcac
     2821 ctaaatcgct attttccttt tttgtaaggt ttattttttg tccctttttt aattctatag
     2881 ccatagtaat cttcctccac aaacatagat ttatttaaat ggtagcactt aataagtcaa
     2941 tattcaacaa gattagaata ataatattaa aattatatta aatatactaa aaagtaggaa
     3001 tcacaatacc tttgtatttt tcttcaatta agcttcttgc tttatctgat gtaagaacat
     3061 cttgtagaac tttaatcttt tcactgtctt tatcttcagt tctaaatgct aaaagatttg
     3121 catactcgtc atttatagga gctgtataaa ttccgttttt cttggcatca agaccagcag
     3181 gtacagcata agtagtatct ataaatgcag cagtcacatc tggaagagaa gatggaattt
     3241 gagcaatatc taactctttg aattgtattc cctttggatt ttctattatg tccttaggac
     3301 taactaatcc atccccttta ggtaacgtta aaagtccaat actttcaagg tatctaaggt
     3361 tcttagaaca agaagatggg ttattgctta ttgcaattgt atctcctttt ttaaattcat
     3421 caacagattt tatcttataa gagtaaagta ttgctggaca tacatatagt tttttaccag
     3481 ccattatttt gtaacctttg gccttaacag cttcttttag ataaggttca tgttgaaata
     3541 gatttgcatc aatttcacca ttatttaaag cttcatttgg aagtatgtaa tcatcaaagt
     3601 ttttaacttc taaagtatat cctttttctt taataagtgg ttttaattct tctaataact
     3661 ctcctcctgg aactaaagta gcaccaacaa caattttttt atcatcttta gctttagaac
     3721 atccaaccac agctaaagtt aatactagac ataataacaa acataataat tttttgaatt
     3781 tcatataaat tccctcctga atataattga ttagttaaaa ataaaatacc attctttatc
     3841 acactgcaaa ataaaaataa gcctgagttt aaactcaggc tttaaaagct aatttagact
     3901 catctttcag tataatactg caggatttag caccaatgta tatagaaaat atactggttg
     3961 ctgggtttca tagggccagt cccttcacca ctctggataa gaagtatcaa tttttaatta
     4021 tgttataaat attatcatga ttttttacgt ctgtaaacat aattttataa atattttaaa
     4081 atctttaatg tattttattt aacacctaaa attccagaaa ctagaatatc agtatcagca
     4141 cctaagaaat agtcatttat ttcaatagaa tccagagtat ttctcaaagc attttcttca
     4201 tgccttatac caataagttt attttctaca aatgcaacat cacattttcc aaaaaaatct
     4261 ccaaaaaatt ttatactagt tattatgcct ttatcaacat ttaaattaaa ctcaacattt
     4321 ccaccagaat attttaattc atttgaaaga gtatattttg gtgaattacc aaaattccaa
     4381 tcccaagttt cgtattttga tttagtaagc ttttctattt gttttatatc atgctcactc
     4441 aaacaataat tagtattatc agtatttgtt ttagaaagat aatccattat agcatcttta
     4501 aattctaata tatccatttt tgaatgtaaa tgttcactta tattggttac acgagatttt
     4561 acagatttta ttccttttcc ttcaaatttt ataggtttaa cctttaatgc ttttgagagg
     4621 tcatttattt cagatgaaaa taaaagagtc ccatgatgca ttactttgtt tttgtagttg
     4681 tattgagcat ttccagaaaa tttcttgcca tctataagaa ggtcatttct tccagaaaat
     4741 tcggcattga catctagtgt tttaagtaaa tctattatgg gctgagtgaa tcttctgaaa
     4801 tcactaaaat tattattgtt acaagctata aatgtaaaat ttatatttcc caaatcatga
     4861 aatacagctc caccaccaga ctgtctccta acgacaggta tagaatattc ttttatatat
     4921 tctaaattta tttcagaaag tgtgttttgg ttttttccaa caattataga aggttcattc
     4981 ctccataaaa taaataagtc ttcatcaaaa ttttttagaa gatattcttc cattgctaaa
     5041 ttaaaataag ggtttgtttt ttcattataa attaataaca ttaaagtagt tcctccatag
     5101 aattgataaa atttttatta tgaatacaat taattttata attcgacaat aatataaaaa
     5161 ctcctttaaa ttagaaattt taaaaactac cttgcaaagt ttaaataaat aatatatact
     5221 caaaatatgt ttaataaaag tgaatagaag ggtagaggcg caataatcta tcagtactaa
     5281 taaggagtta agcacagaga tttattagga aaggagatat tgccgaagtt ttataatcga
     5341 tgctttaaga ttatattgct gggggtacat agaaaatatg tacaactgtc acaggtttat
     5401 ttgtggtgag ctatcattta aggaattata ttatatttat ttttactatt gttgatatat
     5461 tgtaatgttt aagccttgag tgtttaccac tcaaggcttt tttagtttta ttgtaacata
     5521 ataccctgta cagttcacaa aattaaaagg agagggagat ttatatgagg aacaaaaaaa
     5581 ttaatattat ttttctgacg acaatcatgt tcataatgtc aacagtaatg gtttttgcag
     5641 aagaagatat agacactatt gcactagcca atgcagaaaa atttgggatt ttaactttaa
     5701 taccaccatt agttgctata atacttgcat ttataactaa aaacgtaata atttctttac
     5761 ttataggtat tctttctggt agttttataa ttaaagctag tggtattaat gtttttgcga
     5821 catttataca ggcattttta gatttagtag acagagcttt agtatcttta gcagaccctt
     5881 ggaatgcagg gataatacta caggttttgg caattggagg agtaataaat cttgttgcta
     5941 aaatgggagg agctaaagct atagctgaag cacttgctaa aagagcaaag tcagcaaaag
     6001 ggacacagct tataacatgg tttttggggc ttttagtatt ctttgatgat tatgccaatt
     6061 cactaatagt aggtcctatg atgagacctg ttgcagataa aatgaaaata tcgagagaaa
     6121 agctggcatt tataatagat gccacagcag caccagttgc tggtttagct ataatatcta
     6181 catggatagg tcttgaggtt ggtttaatac atgatgcttt tgaaagtata agtatagatg
     6241 tagatgcatt tggtatattt ttaaatacaa taccatttag attttacaat atattaatat
     6301 tagctttcat tgtaatatca gcattattat taaaagaatt tggtccaatg agaaaagctg
     6361 agataaaatc tagaagtaga aaaattagta tagaccttga tgaaggcgta gaagagttgg
     6421 atgatttagc tccaaaaaat ggagtgaaat tgagtgtatg gaatgctata atcccaatag
     6481 gaacattgat aatagttgca ttagcatcat tttattatag tggatataca tctataatgg
     6541 gaggagacga taaggctctg atacaactat ttacaaattc tccatattct tttgaagcaa
     6601 taaaagaagc atttagtgca tctgatgcat ctagagcatt attccagtct gcacttgttg
     6661 caagtttagt tgctattata atggctgtag taaaaaagat ttttacaata tcagaagcaa
     6721 ttgatgtttg gatagatgga atgaaaagtt tagtaatcac tggtgtaata ttaatacttg
     6781 catggtcatt aagttcagta ataaaagagt taggtacagc taaattttta atacacctat
     6841 tatcaggttc actaccacca ttcttattac caagtttaat atttggttta ggagcaataa
     6901 tatcttttgc tactggaaca gcttatggaa caatgggtat acttatgcca cttgcaattc
     6961 cattagcata ctcattaaat cctgatatgt cttatgtaat agtaagtact agtgcagttt
     7021 taacaggtgc aatatttgga gaccattgtt ctccaatttc agatacaaca atactttctt
     7081 caatgggagc tggctgtaat catatagacc atgttaacac tcaaatgcca tatgctatat
     7141 ttacagcagt aatcactatt gtatttgggt atataccagc tggacttgga ttgccaatat
     7201 atatagtatt accagtggca atagctgcta tatttgtagg tattcaaata attggtaaga
     7261 aagttgatga agcggaaata gaacttgtag aataaagata taaataagtt tcacctttta
     7321 ttatcactat tttgttagtt tttagataat tttaaaaagt tattgaaaat aatggcgaaa
     7381 tatagtaaaa taaaagagtg ataagcggat gtggcggaat tggcagacgc actagactta
     7441 ggatctagcg ccattggcgt gggggttcga ctcccttcat ccgcacttta cagtacttaa
     7501 ttgtactgaa aaaaactggg gttgctggct ttcggagtgg gctatcccgt ttttattttt
     7561 ttgtatatat aatagattgg cactttagta taaggtgctt tttttatagg caaaaacagt
     7621 acatttattt ctgttttatt atcattcatc tattagaata tactttagtt aagaatgtgt
     7681 taataagcag tgttcacatt cttgataaaa tgtggaataa tatgtatttt tactaagacg
     7741 gaaatgaaat aattaaacca ttaaataata ttataagatg atgaataagt agataaatca
     7801 aattttgtag gaggatatta tggaaaaata tatatggttg tttccattac tttttatttt
     7861 tcatgatatg gaagagataa taggttttgg aatatggctt aaaaaaaata aatcaatgct
     7921 tgataagaag tatccattta tcagtaaagt ttatgaaaat tatagtactg aaggcatggc
     7981 atttgctgtg tttgaagaat ttattttatg cattattttc tgtatactta cagttataac
     8041 agagaatcag tatgtatatc tactatggtt aggtagtttt atagcatata ccttacattt
     8101 ggtaattcat atagggcagt caatcataat aagaaaatat ataccttcac ttattaccag
     8161 tatcatatgc ttaccaataa gcatttggtg tataagtaag agtatttata tagttgattg
     8221 tgaaatgagt acaacaattc tgtacagtat aattggcatt ataattgtag cattgaattt
     8281 aaagtttgca cagtcgctga ttggaaaatt tacaaagtgg atgtcaaaca tataaatttt
     8341 agtttattgg acagttcaag gaatcagaaa ttggaatttt atagtattaa tattttatag
     8401 tattaatata atgtataaaa ttttatagca atgtatttca taagtataaa gtgactagaa
     8461 ttttaagaaa tatacaaatt ctataaaaac taaataattt caagtatatt ttaaaaatct
     8521 tatttttcac aagtttaaaa ttgtaaacga tttcatcaag tctatgaata tacttttaac
     8581 atgttatagt aaatctcaat ataaatttac atttggttct ttgtgtgtta ttttaataat
     8641 aaattaagtg aaaatgttat tttacattaa tatataatat ctttgcataa gagtgaataa
     8701 tataaaagag aaataattga taataaaaac ttaacaaaaa aattaataca taaaaaaaaa
     8761 taaatataat gtgttgacat ttaattgaaa tattcataca ataaaattga aaataaatat
     8821 ttccaaatga gattagcgag agagtccttt atacgaaaag gcgccgaaga agaaatttaa
     8881 gaaatgccaa tttttagaga agctttcagg caaaaatatc gctaattgat gggactctgg
     8941 agagacttaa gttaagatac tataagtcac cgaagaagca aaataatatt aaattattaa
     9001 atctttcagg tatacaaaca gggatatata ggctaggatt attttccatg ctgatatatc
     9061 ttttttttat gaaaaagtac aggaaataat atcaaagtta cttaaataca gtaggtctaa
     9121 ttttctaggg agggttatat atgaatgaat tgaaaagagt atctttgtac aatatacaca
     9181 aagagcttgg agcaaaactt gttgaatttg ctggttggga aatgccttta gaatatgagg
     9241 gtataaataa agagcatgag aaggtcagaa aaagtgcagg tatatttgat gtatctcata
     9301 tgggagaggt acagataaag ggagcagagt cagaaaaatt tatacaaaac ctagttacaa
     9361 atgatataag cacattaaag ataaatgaca ttatatatac acctatgtgt tatgaaaatg
     9421 gtggagtagt tgatgattta ttaatatata aatttggtga agaagattat ttattagtaa
     9481 taaatgcagg taatatagat aaagatgtag catggataat aaaacaaagt gaaggataca
     9541 atgtagatat aaaaaatata tctagtgaag tgagtcaatt agcaattcaa ggacctaaag
     9601 cagaagaaat tcttcaaaaa atcacagata tagacttaaa ctcaataaaa ttttataagt
     9661 caattccatc aacaaaagta tgtggttgtc cttgtttagt ttcaagaaca ggatatactg
     9721 gggaagatgg gtttgagata tactgtaaaa ataaatatgt agaaataatt tggaatgaag
     9781 ttctaaaggt tggaggagaa gatatatgtc cagctggtct aggttgtagg gatactttga
     9841 gatttgaagc agctctacct ctatatggac atgaaataaa tgaacacata tctccaattg
     9901 aaggtggttt atctatcttt gtgaaaacaa ataaagaatc atttattggc aaatcaattt
     9961 tatcaaaaga aaaagaaagt ggagctaaaa gaaagttagt aggatttgaa atgcaaggta
    10021 aaggaatgcc tagaaatgga tatgatataa ggattggtga taaaacagtt ggatttgtaa
    10081 caacaggatg tgcatctcca acgacaggaa aaattttagg tatgggaatt atagattctg
    10141 aatatgcaaa agtaggaaat gaaataggta tagcaatcag aaaaaaagtt gttcctgctg
    10201 tgatagttaa gaaacctttt tataaaaaac aatataaaaa agataatatt atattaaaca
    10261 aagaaaataa attttcatat atacctgcta caagtgaaga taaatcaaaa atgttaaaag
    10321 tagttggatt aaattcagtt gatgaattat tttcagatat accagaagaa gtaaaattaa
    10381 aaagagattt aaatttggaa attggaaaat ctgaattaga ggtaagcaaa atagtaaaaa
    10441 gattgtcaga agaaaattta agtttagaag acttgacttg ttttcttggt gctggtgcat
    10501 atgaccatta tataccatca attataaaac atataacttc aagatctgaa ttttatacag
    10561 catatactcc atatcaagct gaaataagtc agggaacttt acaagtagtt tttgaatttc
    10621 aatctatgat tgcagaaatt acaggtatgg aaattgcaaa tgcatcaatg tatgatggag
    10681 caactgctgc aatagaagca tgtataatgg caatgaatca gactagaaaa agtaaaatag
    10741 tagtgtcaaa aactattcat cctgaaactc tgtcagtatt aagaacttac ttacaatata
    10801 aagattgtga gatagtagaa attgactttt gtaatgaata tgggactaca gatatagaaa
    10861 aattaaaagc ttctgtagac aaagatacag catgtgttct tatacaaact cctaatttct
    10921 ttggaattat tgaagaaatg gaagaaatag aaaagataac tcatgaaaat aaggctatgt
    10981 taattatgag tgtagaccca atatcattag gagttttaaa aacaccaggt gagataggtg
    11041 cagatattgt tgttggagaa gctcaatcac ttggaaaccc tcttaatttt ggaggtcctt
    11101 atgtaggatt tttagctagc aaatctaaat atactagaaa aatgccagga agaatagttg
    11161 ggcaaagttt agatgtagaa ggtaaaattg catatgtatt aactttacaa actagagaac
    11221 agcatgtaag aagagaaaaa gcaacttcta atatatgttc aaatcaagct ttaaatgctc
    11281 ttgtagcttc aatatatatg gctactatgg gtaaagaagg atttaaagag gttggtatgc
    11341 agtctatgaa aaaagcacat tatacctaca ataaacttgt acaaactgga aaatataagc
    11401 caatatttaa aggtaagttt ttcaaagaat ttgctgtaca aggaaatctt aatatagaaa
    11461 ctataaatga taaactctta gaagaaaata tattaggtgg ttataattta gaatacaatt
    11521 atccagaatt aaaaaattca actttgcttt gtgtgactga gaaaagaagc aaagaggaaa
    11581 tagataagtt agttggaata atggagggat tataatgaaa gaatacaata gtttgttgat
    11641 agatatatct aaaaaaggta ggaaagcata ctcacttcca aagttagata tagatgatat
    11701 aaaaatagaa gatatgattg acccagatat ggcaagacaa agtgagttga atttgccaga
    11761 agttggtgaa ttagaattag ttagacatta tacattatta tcaaataaaa actttggagt
    11821 tgatacaggt ttttatcctt tgggttcttg tactatgaaa tataatccta aaataaatga
    11881 agatatggca gcacttccaa actttactgg aatgcatcca taccaatctt cggatacagc
    11941 tcaaggttct ctttctttga tgtatgattt atcaagaaga cttgcagaaa ttacaggtat
    12001 ggatgaagtt acactacaac cttcagcagg ttctcatggt gagtttacag ggcttatgat
    12061 tataaaagca tatcatgaaa atagaggtga ccataagaga accaaagtga taattccaga
    12121 ttctgcacat ggaacaaatc cagcaagtgc agctatggca aactttgatg tgattcaaat
    12181 agcatctgat aaaaatggag ctgtagacat aaatgtatta aaagaggttt tgaatgatga
    12241 agtagcagct cttatgctta ctaatccaag tactcttggt ttatttgaaa aaaatataaa
    12301 agaaatagct actcttgtac atgaagcagg aggacttttg tactatgatg gtgcaaacat
    12361 gaacgctatt atggggataa caagacctgg agatatgggg tttgatgtgg ttcatcttaa
    12421 tcttcataag actttttcaa ctcctcatgg aggtggaggt ccaggagctg gtcctgttgg
    12481 agttaaaaaa gaattagtac cttttttacc aataccagta attgaaagaa aagaagataa
    12541 gtatgtacta aattatgata gagaaaaatc tattgggaaa attaaaaatt tctatggtaa
    12601 ttttggagtt cttgtaagag cttacacata tatactaact atgggaaggg atggacttaa
    12661 agaggctagt gaaatggcag ttttaaatgc taattatata aaggaaagta taaaagatga
    12721 ttatattttg ccaatagata ccttgtgtaa gcatgagttt gtattaggtg gattgccaag
    12781 aggagaggcc aatataaaaa ctatcgatat tgcaaaaaga ctactagatt atggatacca
    12841 tcctccaaca atgtactttc ctcttattat aaatgaggca cttatgatag aacctacaga
    12901 aagtgagagt atagagacat tagatagttt tatagaagct atgaaaagtg ttgctaaaga
    12961 ggcaaaggaa gaaccagaac tattgaaaac tgctccacat aatactttgg tcaaaagagt
    13021 agatgatgca agggcagtaa agaaacctat actaacatgg tcacaaagat aaatagttaa
    13081 aaagtagaga tttaaagtat aaagagaatt aaatttataa gaaaaagcta tctaacttaa
    13141 tctagtttag atagcttttt tgtatattag tatatatggt atttcctata taaagtttta
    13201 aattatat
//
LOCUS       DAEQCW010000100        13127 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.101, whole genome shotgun sequence.
ACCESSION   DAEQCW010000100 DAEQCW010000000
VERSION     DAEQCW010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13127)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13127)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13127
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.101"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(73..282)
                     /locus_tag="KRO40_002876"
                     /pseudo
     CDS             complement(73..282)
                     /locus_tag="KRO40_002876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861712.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4004 family protein"
     gene            complement(384..932)
                     /locus_tag="KRO40_002877"
                     /pseudo
     CDS             complement(384..932)
                     /locus_tag="KRO40_002877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426706.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(1291..3201)
                     /gene="phnW"
                     /locus_tag="KRO40_002878"
     CDS             complement(1291..3201)
                     /gene="phnW"
                     /locus_tag="KRO40_002878"
                     /EC_number="2.6.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-aminoethylphosphonate--pyruvate transaminase"
                     /protein_id="HBH2093688.1"
                     /translation="MKKIYGEKIKAVVFDWAGTTVDYGCFAPLNVFIEIFKRRGIDVT
                     MEEARKPMGKLKIDHIREMCEMDRIKNIWSDKFGKVPTEDDVNELYAEFEPMLFETLE
                     EYTTPIPHVVETIEKLRKNGLKIGSTTGYTREMMNIVEPNAAKKGYSPDFLVTPSEVS
                     QGRPYPWMCYKNAEALGVSPMSSMVKVGDTISDVKEGVNAGMWSVAVIKGSSELGLTQ
                     EEVENMDKEELKAKMSIVSKKFKEAGAHFVIETMAELEDILIKIENETIKSDFVPEND
                     YILLTPGPLSTTKSVRASMLKDWCTWDVEYNNLVQDVRRRLVSLATQNTDKYTSVLMQ
                     GSGTFSVEAIIGSTISKDGKLLVIANGAYGKRMKDICNYLNIQFVDCTFKDIEAVDLN
                     VVENLLKENKDITHISMVHCETTTGRLNPIQEVGKLAKEYNKIYIVDAMSSFGGIEID
                     VEDFNIDFLVSSSNKCIQGVPGFGFIIANKEKLSKCKGIAKSLSLDVYAQWETMEKNN
                     GKWRFTSPTHVVRAFYQALLELEEEGSVEKRYARYKENQFTIASRLKSLGFDTLVNDN
                     AQSPVITTFLYPKNAKFEFMEFYTYLKDNGFVIYPGKLTDIDTFRIGSIGEVYPTDME
                     RLADVIEKFINR"
     gene            complement(3480..4265)
                     /locus_tag="KRO40_002879"
     CDS             complement(3480..4265)
                     /locus_tag="KRO40_002879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH2093689.1"
                     /translation="MSLNSIDRKKEILKLLDSKGKVNTKELVKRLEVSSETIRRYLEE
                     LENENKLKKVYGGAIKINYGVIEPEHIKRNNTNLDKKQSIAKYAAKFVNDNESIIIDE
                     GTTNLQIVDYIISVNNLKIITNSYPVLSKLISYENQGLFDGEVIFIGGKVNLKHQRTA
                     CPMSIDTMKNLYVDKAFISSEGILDSFGISSIDQNKALLSKEYIKNSKESFVLCDSSK
                     IGIASMYKIADLEELDFVICDVEPPNEWKDKLNEINITWIEAK"
     gene            complement(4482..4712)
                     /gene="dltC"
                     /locus_tag="KRO40_002880"
     CDS             complement(4482..4712)
                     /gene="dltC"
                     /locus_tag="KRO40_002880"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HBH2093690.1"
                     /translation="MQETVIEIFEDVLGTDEIREDLDLNLFETELLDSLAIIEVLLEI
                     ENRLGIELQPTDLERKDMSTVNNLVKFLETRK"
     gene            complement(4731..5879)
                     /gene="dltB"
                     /locus_tag="KRO40_002881"
     CDS             complement(4731..5879)
                     /gene="dltB"
                     /locus_tag="KRO40_002881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HBH2093691.1"
                     /translation="MIFSQYGDYFYLYILLLTSIPAVILGLMGKNIKYYGMLASLFMI
                     FLIVGIDVQLKYLVIFIILEVIIVKGYEYVRRKTKNKYIYWGFLFASMLPIIINKISP
                     VTSFGIIGFIGISYLNFRTIQMVIEIYDGAIKEVKISKMLYFMLFFPTLSSGPIDRSR
                     RFEQDLEKQISRKEYIEEYLLPGIKNIVMGVGYKFVIAFLINTYWVSRIPKDMSFINI
                     LSYMYAYSLYLFFDFAGYSLFAIGTGYIFGIQVPINFDKPFISKDMKEFWTRWHISLS
                     RWFGDYIFSRFVMSSMRKKRFKKRTTAAHVAQMITMITMGFWHGLTWCYVAYGVYQGL
                     ALVLTDIYQRKSKFYKKHKKDKWFERVQIFITFHIVCFGLLIFSGYLA"
     gene            complement(5879..7393)
                     /locus_tag="KRO40_002882"
     CDS             complement(5879..7393)
                     /locus_tag="KRO40_002882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase"
                     /protein_id="HBH2093692.1"
                     /translation="MKIIEGIKKYSNTDRTALMCNGDKLSYKDLNEYSDAISVFLKDV
                     YKEEDTPIVIYGNKENMIMACMIGALKSGRAYVPLDISFPIDRVFEVTKEIKPKVLFN
                     FSDERNFGDINVIDMDKLNDIINEYQGKSLDKENWVKDDENAYILFTSGSTGKPKGVQ
                     ISSNNLDSFSDWISPYLNIDGSEKVIMNQPAYSFDLSVTTIYPGLIHGATLFSISKDV
                     LADYRELFRQFSISDIAVWVSTPSFAGVCITEKEFNSKMLPNLESMIFIGEALSKNLT
                     KELMSRFPNTRIINGYGPTEATVGVSVNDMTQKAIDDEKSLPVGYPMSNCKIKILDED
                     GNELKENEKGEIIIIGPSVSKGYFNNKEKTDEVFFYDEIDGVKWRAYKTGDMGYLLDG
                     NIYYCGRKDFQIKLNGFRIEIEDIENNLRKVHNVKNAVVLPVYKDEKIAYLKGIVELN
                     EKNDLSNIKNGMIIKKELGKYIPSYMIPRNISIISEFPTNINGKIDRKKLMEEI"
     gene            complement(7514..8704)
                     /gene="dltD"
                     /locus_tag="KRO40_002883"
     CDS             complement(7514..8704)
                     /gene="dltD"
                     /locus_tag="KRO40_002883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HBH2093693.1"
                     /translation="MRKLIYFITPFIIGVVFLFGLDKFLDSKTDELLREKNLLPIMDD
                     TLSDIKDKGVTANNHFLREKDIMILGSSELSNSTKQHPKYYFNTNRSKNKVFAIGRAY
                     TQTLQDAAILGSMNPNIDNKKVVLLISMQWFMEKDGVTSHHYQSRFSPIQFYRFLDNP
                     KISKQNKIEYAKKSSKLLWGSDEYKAEALYAKLYEPKTFPEKAEKVLLEPYFQGRKYC
                     IALKEKGILYKRLIKLDKKRATKRKRPINWSYERKKAIEDAKKRVGKNPLNIDKYYYK
                     EHFKDGIEQYKGRDKDVNLLTSKEFENYKLMLNVCTDLGIKPVVVLIPSMDKFYNLTG
                     ISEKERNQYYDKAQKIAESKGFEVLNLKDKGSDKYYLRDVMHLGTKGWVDVCERLFKI
                     FKEQ"
     gene            complement(8992..10011)
                     /locus_tag="KRO40_002884"
     CDS             complement(8992..10011)
                     /locus_tag="KRO40_002884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBH2093694.1"
                     /translation="MMGKIRFGIVGTSNIANIFLRAASRVKDFELVAVYSRNLEKARE
                     FGTLYGASIFFDDLEQMAKSKDIDAVYIASPNALHSKQTITCLKHKKHVLCEKSLASN
                     LKEVKSMIKTAKDNNVLLMEAMRITCVPNFKAVKENLYKIGKIRRFFGSYCQYSSRYD
                     KYKNGIIENAFKKELSNGALMDIGVYCIHPMVNLFGAPKTVKAVSHILQTGVDGEGSA
                     VFQYDDMDAIIQYSKVADSYIPSEIQGEEGSIIIEKLNLFEKAIIKYRDGREEDISIP
                     KEKAEEKPREIEGMYYELVEFISLINNNKIESNINSHENSIIVMEIMDEIRRQSSIVY
                     PADSI"
     gene            complement(10187..10726)
                     /locus_tag="KRO40_002885"
     CDS             complement(10187..10726)
                     /locus_tag="KRO40_002885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transporter permease"
                     /protein_id="HBH2093695.1"
                     /translation="MDNVGSLLYFLFNFFLYGFIGWIIENLYSYYKQGHFQEDGFLNG
                     PFKPMYAIAMSIIIEVSRFIDPNNIFALLLLCLVVPTVVEYITGILMKVYFNKVYWDY
                     SDYKYNSRGIVCLKFSVYWTILTFIGVRYFQVYIVDSLYSLIIPYWPIVVTILLVTLF
                     VDEILTIKFLRGNKDIVER"
     gene            complement(10827..11507)
                     /locus_tag="KRO40_002886"
     CDS             complement(10827..11507)
                     /locus_tag="KRO40_002886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family phosphatase"
                     /protein_id="HBH2093696.1"
                     /translation="MQNVEGIIFDMDGVLFDSERISLEFWMETFEKYGYTMTKEIYTS
                     VMGRNRKGIIEGLTDIYDSSVPIIDLYDEKTKNMIEFMERKGAPIKLGVNELISFLKE
                     NGYKMAVATSTKRERAVKRLAKANLKDYFDAIVCGDDVVNSKPNPEIFLKAAKKINVN
                     PKNCIVIEDSPMGVEAAYNGGIRCINVPDLKEPDEQIKSQSHKILENLLEVREYLKSL
                     NSKECHNL"
     gene            complement(11536..12825)
                     /locus_tag="KRO40_002887"
     CDS             complement(11536..12825)
                     /locus_tag="KRO40_002887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HBH2093697.1"
                     /translation="MRELLKVTLIVMLVLINAFFVACEFAMVKLRSSRIDTMITEGNN
                     NAKRCKIIKDNLNSYLSACQLGITLCSLALGWMGESTVKELILPIVSVFNLSESIIYT
                     ISISISFLIITMMEVVIGELVPKALALYNTEKIMLSTSFLLVGFYKLTYPIIYFFNLS
                     TDLFLKPFGYSQADEVDEPHTGDEIRLLVEESYKSGLIDESEQRLVDNIFEFEEKKIR
                     EIMVPRTDMVCIYESDSEEKILAILKEEGVTRYPVCRKNKDDILGFVHIRDLYNQKIN
                     ENKIELEEILRDIIYISENLTIDKALERIRKEKLQLAIVVDEYGGTSGVVTIEDILEE
                     IVGEIQDEFDKEETHIKKIGAGSYLVDGTESINYINKYFGLDIEHDGFDSIGGWISYM
                     LGSNIKVNQSVTFENYNFTILELDKLRVVKLIIKSVI"
BASE COUNT         4235 a         2353 c         1256 g         5283 t
ORIGIN      
        1 gtttccctat atgctgacta ttttagctac taactcatga ctaaagtcac aagtgtgcat
       61 agctattttt taatcaagag aagtctcttc tttcatagac aatattaact ctattctttc
      121 tagtatttta tctcttggaa agaaagtctc ttgacctgta aaagctgatt tttttataaa
      181 ccattcctct ggtattatgt tttttctttt ccatctatat aattgtccat aagatatatt
      241 agttttgctc aataaatctt tcttagatat taattcttcc atagctcttc tagcccacct
      301 ttatactgtt ttttacagta gaattatctg aaactgataa attatcactg tattcaatat
      361 ttccaacatc ataattatct actagagata tgcttttttt ctagcatacg aaattttttg
      421 caataatctc catgcccctt ttttatattt atactacttg ctccaacttc attaaaatta
      481 gaagttccat ttaaactaat attaacttct tcacaattca aaaatccatt acactccaag
      541 attccactta aattgatatt ttcacaatct atattctcat ttgcttttaa atatccttct
      601 ccatgaataa tatccgattt tatacttcct tctacattaa taattccact agtatcaatt
      661 tcaacagaat taatatttcc tgtacatcta agaagtcccg atatctcaac ttttgatgcc
      721 agtatgtttc cttctacttt acttaaacca gatgtaaaaa attcattaca ttctgttgtc
      781 ccaaaaactt ttgctgaacc agaagaatca aatttactac attttacact tccttctatt
      841 ttgcctgttc ctgatatatt aacattatca aaaattccac ctttacattt tccaacacca
      901 tcaaatctta gtgaacttaa ttcttcattc ataatgatat cctttcttta ccgtatttta
      961 tctttaaacc taatataaca aaacattgtt acgttgtcaa gtatgataat aatacttaat
     1021 aaagcaacta tcatttattt tctataaata ggcataaaaa taatagggaa atgctttatt
     1081 taaactataa atctaatttc ttagattgtg gtttaaataa aatatatccc tattactcaa
     1141 tgtttatata ttcattgtat aaacttctaa aatataagtc tttaaattct actgtcaata
     1201 ctttttatac actgtttgtg ctatcatctc acacacctaa aggagtaggc tttgcgcact
     1261 attctgtaac ctacaagaca ctatcttctt ctatctattg ataaattttt ctattacatc
     1321 agctagtctc tccatatcag ttggatagac ttcacctatg ctacctattc taaatgtatc
     1381 tatatcagtc aatttacctg gatagataac aaatccatta tcttttaaat aagtataaaa
     1441 ttccataaat tcaaactttg catttttagg atataagaaa gttgttatta caggtgattg
     1501 agcattatca ttcaccaaag tatcaaagcc taaagatttt aatcttgaag ctattgtaaa
     1561 ctgattttct ttatatctag catatctttt ttcaacagaa ccttcttctt ccaattctaa
     1621 taaagcttga taaaaagctc ttacaacatg tgtaggtgaa gtaaatctcc atttaccatt
     1681 atttttctcc atagtctccc attgcgcata cacatcaaga gataatgatt tagctatacc
     1741 tttacattta gataatttct ctttattagc tattataaaa ccaaatccag gtactccttg
     1801 tatacatttg ttagaactac taactaaaaa atctatatta aaatcttcaa catcaatctc
     1861 aattccccca aaactactca tagcatcaac tatataaatt ttgttatatt cttttgcaag
     1921 tttccctacc tcttgtatag gatttaatct acctgtagta gtttcacagt gaaccattga
     1981 tatatgtgtt atatccttgt tttcttttaa taaattttct actacattta aatccactgc
     2041 ttctatatct ttaaatgtgc agtcaacaaa ttgtatgtta agataattac atatatcttt
     2101 cattctcttt ccatatgctc catttgcaat tacaagaagt ttaccatctt ttgaaatagt
     2161 acttcctatt atagcttcta ctgaaaaagt cccacttcct tgcattaata cacttgtgta
     2221 tttatctgta ttttgggttg ctagagatac taatcttctt ctaacatctt gtactaggtt
     2281 attatattca acatcccaag tacaccaatc ttttaacata gatgctctta ctgatttagt
     2341 agtagatagt ggtcctggtg taagtaatat gtaatcattt tctggtacaa aatctgattt
     2401 aatagtttca ttctctattt ttattagtat atcttctaac tcagccatag tttctattac
     2461 aaaatgtgca cctgcctctt taaatttctt tgaaactata ctcatcttag cttttaattc
     2521 ttccttatcc atgttctcta cttcttcttg tgtaagccct aactcacttg aaccttttat
     2581 tacagcaaca ctccacattc ctgcatttac gccttctttt acatcactta ttgtatctcc
     2641 tacttttacc atagaactca taggagacac ccctaaagct tcagcatttt tatagcacat
     2701 ccaaggatac ggtcttcctt gagatacttc tgatggtgtt acaagaaaat cgggtgagta
     2761 tcccttcttt gctgcatttg gttcaactat gttcatcatc tctcttgtat aacccgttgt
     2821 agaacctatt tttaatccat tttttctcaa cttttcaata gtttcaacaa catgaggaat
     2881 tggagtcgta tactcttcta atgtctcaaa taacattggc tcaaattcag cataaagttc
     2941 atttacatca tcttcagttg gcactttacc aaacttatct gaccaaatat tctttattct
     3001 atccatttca cacatttctc ttatatggtc tatttttaat tttcccatag gttttcttgc
     3061 ttcttccatt gttacatcta tacctcttct tttaaatatc tctataaata cattaagagg
     3121 tgcaaaacat ccataatcta ctgttgttcc agcccaatcg aatactactg cttttatttt
     3181 ttctccatat atctttttca tatttatagc ctccatagat tctttttaga atttttgtgt
     3241 ttttaattgt ttttactttt aaagtataac tttcatatgt taattataca tcatatttag
     3301 gttaaatata tattaaattt ctgtttttag ttgtatttag ttgtttttat tttgtatcat
     3361 attcccataa aatcctaagt tacaatctaa aatttacttt ctaatcttaa tctatgaact
     3421 gactatattt tatgaattta gttgtattga gcatagttgt attatataaa actaagggtt
     3481 tattttgctt ctatccatgt tatatttatc tcatttaact tatccttcca ttcattcgga
     3541 ggttctacat cacaaataac aaaatctaat tcctctaaat ctgctatctt atacatacta
     3601 gcaattccta ttttagaact atcacataat acaaaacttt cctttgaatt ttttatatat
     3661 tcttttgaca acaatgcctt attttggtct atactactaa ttccaaaact atcaagtata
     3721 ccttcactag atataaaagc tttatctacg tataagtttt tcatagtatc tattgacatt
     3781 ggacatgctg tcctttggtg ttttaaattt acttttccac caataaatat aacttctcca
     3841 tcaaacaaac cttgattctc ataagaaatc aattttgata gaactggata agagtttgta
     3901 ataattttta aattgtttac agatattata taatctacaa tctgcaaatt ggtagtacct
     3961 tcatctatga taattgactc attgtcattt acaaacttag ctgcatattt agcaatactt
     4021 tgctttttat ctaggttagt attgtttctc tttatatgtt ctggttcaat cactccataa
     4081 tttattttta tagcaccacc atataccttt tttaatttat tttcattttc taattcttcc
     4141 aaatatcttc ttattgtttc tgatgatact tctaatcttt ttactaattc tttagtgttt
     4201 accttccctt ttgaatctaa taatttaagt atttcttttt ttctatctat cgaatttaaa
     4261 gacattcatt ttcctcctaa atataatata tttttctcct ataatattac aatgatacct
     4321 aagatttatg aaatcatatt tatgtattaa attttttact taattaaagt tattttcaaa
     4381 agactttgta ttatcattaa aaaagtccat caaatattag tatcagatgg actttgtaaa
     4441 attttatttt ataaattaat atttaaagtc taactactaa tttattttct tgtctccaag
     4501 aattttacta aattatttac agtagacata tcttttctct ctaaatcagt tggttgaagc
     4561 tctatcccta atctattttc aatttcaagt aaaacttcaa ttatagctaa tgagtctaaa
     4621 agttccgtct caaataaatt aaggtctaaa tcttctctta tctcatcagt ccctaataca
     4681 tcttcaaata tttctataac tgtttcttgc ataaattttc ctccttaaaa ttaagctaaa
     4741 taacctgaga atatcagcaa tccaaaacac acaatatgga atgtaatgaa aatctgcact
     4801 ctctcgaacc atttatcttt tttatgtttt ttataaaatt tagattttcg ctgatatata
     4861 tcagttaaca caagtgccaa tccttggtat acaccataag caacataaca ccaagttaga
     4921 ccatgccaaa atcccattgt tatcatggtt atcatctgag ccacatgagc agcagtagtc
     4981 cttttcttaa atcttttctt tctcattgat gacataacaa atctagaaaa aatataatct
     5041 ccaaaccatc ttgaaagact tatatgccat cttgtccaga actctttcat atctttgctg
     5101 ataaatggct tgtcaaagtt tataggtact tgtattccaa atatgtaccc tgtacctata
     5161 gcaaataaac tatatcccgc aaaatcaaag aacaggtata aactatatgc gtacatataa
     5221 cttaaaatat ttataaaact catatcttta ggtattcttg atacccaata tgtatttatc
     5281 aaaaatgcta taacaaactt ataacctact cccatgacaa tattttttat tcctggcagt
     5341 aagtattctt ctatatactc ttttctagag atttgttttt ccaagtcctg ttcaaatctt
     5401 cttgacctat caataggtcc agaacttaaa gttggaaaaa ataacataaa ataaagcatc
     5461 tttgaaattt taacttcttt tatagctcca tcataaattt caataaccat ttgtatagtt
     5521 ctgaaattta agtatgatat tccaataaat ccaattattc caaaagaagt aactggagat
     5581 attttattta ttattattgg gagcattgat gcaaacaaga atccccaata tatgtattta
     5641 tttttagttt ttcttcttac atattcatat cctttaacta ttattacttc aagaataata
     5701 aatattacca agtactttag ttggacatca attcctacta ttaagaatat cataaacaaa
     5761 cttgccaaca taccataata ctttatattc ttgcccatta gacctaaaat tactgctggt
     5821 attgatgtta ataataatat ataaagataa aaataatctc catattgtga aaaaatcatt
     5881 aaatttcctc cataagtttc tttctgtcta ttttaccatt gatatttgtt ggaaactcag
     5941 agattattga aatatttctt ggaatcatat atgaaggtat atactttcca agttcctttt
     6001 ttattatcat cccattttta atattactta aatcattctt ttcatttaac tcaacaatac
     6061 cttttaagta agcaattttt tcgtccttat atactggtaa aactactgca ttttttacat
     6121 tatgtacttt tctcaaatta ttttctatat cttctatttc aattctaaat ccatttaatt
     6181 taatctgaaa atcttttctt ccacaataat atatatttcc atctaaaaga tatcccatat
     6241 ctccagtttt ataagctctc cactttacac catctatttc atcatagaaa aatacttcat
     6301 cagtcttttc tttattattg aagtaacctt tagaaactga tggtccaatt attataattt
     6361 cacccttttc attttcttta agctcatttc catcttcatc aagtattttt attttacaat
     6421 ttgacatagg gtatccaact ggaagacttt tttcatcatc tatagccttt tgagtcatat
     6481 catttacact tacaccaaca gtagcctcgg ttggtccata tccattgata attcttgtgt
     6541 ttggaaatct actcataagt tctttagtaa gattttttga aagtgcttct cctatgaata
     6601 tcattgactc aaggttagga agcattttac tattaaactc tttttcagtt atacatactc
     6661 ctgcaaaaga aggagttgag acccatacag ctatatctga gatactaaat tgtctaaata
     6721 gttctctata gtctgctaat acatcttttg atattgaaaa taatgtagct ccatggataa
     6781 gaccagggta tattgttgta actgaaaggt caaaagaata tgctggttgg ttcattatta
     6841 ctttttcact tccatctatg tttagatatg ggcttatcca atctgaaaag ctatctaaat
     6901 tgtttgaact tatttgaacc ccttttggct ttcctgtact tcctgaagta aatagtatat
     6961 atgcattttc atcatctttt acccagtttt ctttatctaa tgattttccc tgatattcat
     7021 ttattatatc atttaattta tccatatcaa ttacattgat atctccaaaa tttctttcat
     7081 cactaaagtt aaataatacc tttggtttta tctctttagt gacttcaaaa actctatcaa
     7141 ttggaaaact aatatcaaga ggcacatacg ctctacctga ttttaaagct cctatcatac
     7201 atgccattat catgttttct ttatttccat aaattactat aggagtatct tcttctttgt
     7261 atacatcctt tagaaatact gatatagcat ctgaatattc atttaaatct ttataagaaa
     7321 gtttatctcc attacacatt agtgctgttc tatctgtatt tgaatatttt tttattcctt
     7381 caataatttt catataagaa tgctccttta aaatccgtta taaataaatg gcaattcttt
     7441 aaatggagta aatgttagaa ctcctatcgc caatattata accatagtta aacaaatact
     7501 agttaacaaa tctttattgt tctttaaata ttttaaataa tctctcacag acatctaccc
     7561 atcctttcgt accaagatgc attacatccc ttaaataata cttatctgac cctttatctt
     7621 taaggtttag aacttcaaag cctttgcttt ctgctatttt ttgcgcttta tcgtagtact
     7681 gatttctttc tttttcagaa ataccagtca aattatagaa tttatccata cttgggatta
     7741 atacaacaac tggcttaata cctaagtcag tacatacatt tagcatcagt ttataatttt
     7801 caaactcctt agatgttaat aaatttacat ctttgtctct tcctttgtat tgctctatac
     7861 catctttaaa atgctcttta taatagtact tatcaatatt tagtggattt ttaccaactc
     7921 tttttttagc atcttcaatg gctttctttc tctcatatga ccaatttatt ggtctttttc
     7981 tttttgttgc tctcttttta tctagcttaa ttaatcgttt ataaagaata cccttttctt
     8041 taagagctat acaatacttt cttccttgaa aataaggctc taaaagcacc ttttcagctt
     8101 tttcaggaaa tgtcttaggc tcatatagct tagcatataa tgcttctgct ttatactcgt
     8161 cacttcccca taataactta cttgattttt ttgcatattc aatcttattt tgtttagata
     8221 tttttggatt atctaaaaat cgataaaatt gtattggtga aaatctagac tgataatggt
     8281 gacttgtgac tccgtctttt tccataaacc attgcataga aattaacaag acaactttct
     8341 tattatcaat attaggattc atacttccta atattgcagc atcttgtaat gtctgagtat
     8401 aggctctccc aattgcaaac accttatttt tactcctatt tgtattaaaa tagtactttg
     8461 gatgttgttt tgttgaatta ctaagttctg atgaccccaa aatcataata tccttttctc
     8521 ttaaaaaatg attatttgct gtaacccctt tatcttttat atcacttaaa gtatcatcca
     8581 taattggaag tagatttttc tccctcaaaa gttcatcagt tttagaatca agaaatttgt
     8641 ctaacccaaa taaaaatact acgcctatta taaaaggtgt aataaagtat atcaattttc
     8701 tcatattttc tctcctctaa aaatattcaa atttatgtta ttattaatca tattagtttt
     8761 gatatgtata ttcaactaca aaattgtaat aaaatcgtca aaactttttt tgatactgtt
     8821 acaaaattgt aaaaaaaaag aaaaaaacgc caaaaataaa tttcttttta gcactttttc
     8881 atacttataa tttgacattt taacacttgg ttaagtatac accttacctt aacttaaaat
     8941 taaatttatt taagaatata tattataaat tcttatattt tctaatataa actatatact
     9001 atcagctgga taaacaatac tactttgtct tcttatctca tccataattt ccattactat
     9061 tattgaattt tcatgagaat ttatatttga ttctatttta ttgttattta taagacttat
     9121 aaactctaca agttcataat acattccttc tatttctcta ggcttttcct ctgctttttc
     9181 ttttggaata gatatatctt cttctcttcc atctctgtat ttaataatag ctttttcaaa
     9241 tagattaagc ttttcaatta ttatacttcc ctcttctcct tgtatttcag atggtatata
     9301 agaatcagct actttagaat actgaattat cgcatccata tcatcatatt gaaatacagc
     9361 tgaaccttct ccatccactc cagtttgaag tatatgagaa actgccttta cagtttttgg
     9421 agcaccaaat aaattcacca taggatgtat acaatacact cctatatcca ttaaagctcc
     9481 atttgacaac tcttttttaa aggcattttc tataattcca tttttatatt tatcatatct
     9541 tgaagaatac tgacaatagc ttccaaaaaa tcttcttatt ttccctattt tatataagtt
     9601 ttctttaact gctttaaagt ttggaacaca tgtaattctc atagcttcca taagcaatac
     9661 attattatct ttggctgttt ttatcattga tttgacttct tttaaattag atgctaacga
     9721 cttttcacaa agcacatgtt ttttgtgttt taaacaagta atggtttgct ttgaatgtaa
     9781 tgcatttgga gaagctatgt atacagcatc tatatccttc gatttagcca tttgttctaa
     9841 atcatcaaaa aaaatacttg ctccatatag agttccaaat tctctagctt tttctaaatt
     9901 tctagaatat acagcaacca attcaaagtc tttaacccta gatgcagctc ttagaaatat
     9961 atttgctata ttgcttgtcc caacaatacc aaatcttatt ttacccatca taaatcactc
    10021 cccattttct acactttatt ttaattttaa taaaaaactt tacaacttat agatatatta
    10081 taaaataatt ttatcaaata aaaaagaaag ctaattttaa atgatttcac cattttaaca
    10141 tagctttctt ttaactacaa tctaaattca acttatattt ttaaagttat ctttctacta
    10201 tatctttatt tcccctcaaa aattttatag taagaatttc atccacaaac aatgttacta
    10261 aaagtatagt tacaacaatt ggccaataag gtattataag actatataaa ctatcaacta
    10321 tatacacttg aaaatatcta actccaataa atgtcaatat agtccaatat acagaaaact
    10381 ttagacatac tattcctcta ctattgtact tataatctga ataatcccaa tagaccttat
    10441 taaaatatac tttcataagt attcctgtaa tatattctac tactgtcggc actactagac
    10501 ataataaaag caatgcaaat atattattgg ggtcaataaa tcttgagacc tctattataa
    10561 tcgacattgc aattgcatac attggtttaa atggaccatt taaaaatcca tcttcttgaa
    10621 aatgcccttg tttataataa ctatataagt tttcaattat ccaacctata aaaccataca
    10681 agaaaaaatt aaataaaaaa tataatagag aacctacatt atccatgaat attcctccta
    10741 gctgtttata cttatttttt ctcatattca tggatttatt ctaaatcaaa gaaattatat
    10801 ttaatttatt taattaatac tttatattat agattgtgac attctttaga gttcaaactt
    10861 tttaggtatt ctctaacttc cagtaaattt tcaagtatct tatgtgattg tgatttaatt
    10921 tgctcatctg gctcttttaa atctggtaca tttatacatc ttataccacc attgtatgca
    10981 gcttcaactc ccataggcga atcctctatg acaatacaat ttttgggatt aacatttatc
    11041 tttttagctg cttttaagaa tatctcaggg tttggtttag agtttacaac atcatctcca
    11101 caaactatag catcaaagta atcttttaaa tttgccttag ctaatctctt tactgctctt
    11161 tctctctttg ttgatgttgc aacagccatt ttgtatccat tttcctttaa aaaagagatt
    11221 agttcattga ctcctaattt gataggagct cccttcctct ccataaattc aatcatattt
    11281 ttagtttttt cgtcatataa atctattatt ggtacagaac tatcgtatat atctgtaaga
    11341 ccttctatta ttcctttacg atttcttccc ataactgatg tataaatttc cttagtcata
    11401 gtatatccat acttttcaaa cgtctccatc caaaattcaa gagaaattct ctctgagtca
    11461 aacaaaactc catccatgtc aaaaataatt ccttctacat tttgcataca attcctccaa
    11521 tattttttga tataattata ttacactttt tatgattaat tttacaaccc tcaatttatc
    11581 caattctaat attgtaaaat tgtaattttc aaaagttaca ctttggttta ctttaatatt
    11641 tgaaccaagc atataggata tccatccacc tatactgtca aatccatcat gctctatatc
    11701 aagtccaaaa tacttattaa tatagttgat agattcagtt ccatcaacta agtaagaacc
    11761 tgctcctatt ttcttaatat gagtctcttc tttgtcaaat tcatcttgaa tttctccaac
    11821 tatctcttct agtatatctt ctattgttac cacaccagat gtaccaccat attcatccac
    11881 aactatagca agttgaagtt tttcctttct tattctctca agagctttat ctatagttaa
    11941 attttcagat atatatataa tatctctcaa tatttcttct agttcaattt tattttcatt
    12001 tatcttttga ttgtataaat ctcttatatg tacaaaacct aatatatcat ctttattttt
    12061 tctgcatact ggatatcttg taacaccttc ctcttttaaa atagctaata tcttttcttc
    12121 agaatcactt tcatatatac ataccatatc agttctagga accattatct ctctaatttt
    12181 cttttcttca aattcaaaaa tattatcaac taatctttgc tctgattcat ctataagtcc
    12241 acttttataa ctttcttcta ctaatagtct tatttcgtca cctgtatggg gttcatcaac
    12301 ctcatcagct tgtgaatatc caaatggttt aagaaataaa tcagtactta agttgaaaaa
    12361 atatattatt ggatatgtta acttataaaa tcctactaat aaaaaagatg tactcaacat
    12421 tattttttct gtattataaa gtgctaaagc tttaggaacc aactctccta ttacaacctc
    12481 catcattgtt ataattaaaa aagaaatgga aattgatata gtatatataa tactttcact
    12541 aagattaaat acacttacta ttggtaaaat taactcttta actgtagatt ctcccatcca
    12601 acctaatgca agtgaacaaa gtgttatacc aagttgacat gcagaaagat aggaatttaa
    12661 gttgtctttt attattttac atctttttgc attattatta ccttcagtta tcatggtatc
    12721 aatcctagaa ctacgaagtt ttaccatagc aaattcacaa gctacaaaaa aagcatttat
    12781 caaaacaagc attactataa gtgttacttt taataactcc cgcataaagt attggttctt
    12841 ataatgtaag aaatctataa gaactcaaag ttcccccctt atattaataa atttaattta
    12901 taatatatat tctatcatat ttattaatat atcctacttt attacaaata atttttataa
    12961 actaaataac cccttttaat atttatgact ggctatttga taaatattaa aggggttatt
    13021 tagttatcat tttttatttc taaaaatctt ttctcaaatg atttagttat ctatttatcc
    13081 aattttttac ataatttaat gattaaaaat attaattttt tcactat
//
LOCUS       DAEQCW010000101        13085 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.102, whole genome shotgun sequence.
ACCESSION   DAEQCW010000101 DAEQCW010000000
VERSION     DAEQCW010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13085)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13085)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13085
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.102"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            179..3076
                     /locus_tag="KRO40_002888"
     CDS             179..3076
                     /locus_tag="KRO40_002888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093698.1"
                     /translation="MKAFKKHFLILSLIFLLIISCFNNILCFADESENSKKIRVGYCD
                     DYGIISSSKEHSYTGYGYDYLREISKYTRWEYEFVKGSWEECLDRLEKGEIDLLGPLQ
                     KNDERNKLFNFPKLSSGYEYSALYTKDSNNNMFYEDISSFKGMRVAVLRGNFHNTAFE
                     KYREENNFSVEYIYCNSIDELIESVNEKKADAFVCGSIINAKGMKIVSKFSVEPFYFA
                     TAKDKPNLVKELDYALKELKINDMYYELELYKKYFKREVNNSIAFTRQEMNFIKANPK
                     LTMVYDSEWSPVEYYDKESNSFKGISSDLMSIISKKCGIKFEYIKTKNYNESLDYIKS
                     GKATMLCGSINENDKAKRFNMKLTNPYINIPMIMVGKLDTNLNNDLNIALTSSYKSID
                     SYIEKSFENAKTTSYKSVESCLNAINEGKANLMILSSYQFDELLREGKSENLSVISVL
                     DTSYGMRIGVSNKTDPILVSILNKSIDKITEEELSDCIYSNTIDKPYKVPFGVIFKEY
                     SIQIISFVCILFLIAIKYIIYNKKKKEDYLRKIAYTDPLTGADSIDKFKINSNKLFAK
                     NNPEEYALFYIDVDKFKYINDMFGYDMGNDTLIHISNTIASELKEDEIFARVSADHFV
                     LLIKYKTDDDIKTRLNNIYNKVQILSNPKINYYKLILDCGIYKISKSDNDINTIMDRA
                     NTARKTIKGGHKNSFAFYDKEMHKKILKEKEIENSMVDALNNGEFIVYFQPKYSLSDY
                     QIIGAEALVRWDNPQKGLIPPIEFIPVFERNGFIVNIDFYVFEEVCKKIREWMDEGQK
                     VVPISVNLSRMHFVNSNFIEKFKLIVDKYKIPTRLIELELTETAVLDNIEGLLDTMNN
                     LKEKGFVISMDDFGTGYSSLNLLKELPVDILKLDRAFFTEKDESNNEKIVISNVIKMA
                     KELKMKVISEGVETISQVEFLKQIGCDMVQGYLFSKPMPVKEFEKIAFKKE"
     gene            3397..3609
                     /locus_tag="KRO40_002889"
     CDS             3397..3609
                     /locus_tag="KRO40_002889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH2093699.1"
                     /translation="MMPLILSNTGEEVVIKKISGSDKTRTFLNSIGFVVGTNVKIVSK
                     IDGNLIIDVKDTRVALDKKMASRIII"
     gene            3622..3843
                     /locus_tag="KRO40_002890"
     CDS             3622..3843
                     /locus_tag="KRO40_002890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH2093700.1"
                     /translation="MNRLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKV
                     APLGDPIEVTVRDYELSIRKSDAEKIIVE"
     gene            3943..6099
                     /gene="feoB"
                     /locus_tag="KRO40_002891"
     CDS             3943..6099
                     /gene="feoB"
                     /locus_tag="KRO40_002891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH2093701.1"
                     /translation="MSIKIGLIGNPNCGKTTMFNGLTGSSQYVGNWPGVTVEKKGGKL
                     KGNKDVEIVDLPGIYSLSPYTLEEVVTRNFMLDDKPDAVINIVDASNIERNLYLTTQV
                     LELGIPTVIALNMMDIVNKNGDKINIKELSEVIGCPVVEVTAVKGQGIMEAAEKAVEL
                     ASSNNKLNFKLPFVDESKDAIEKIEKIIEEKTPYIDVETRWLAIKLFERDENVIQKLD
                     ISKTILNSIEEITRNCEDELDDDSESIITANRYEFISSIISSIIKKNRKGKETVSDKI
                     DKIVTNRILALPIFALIMWGVYYIAVSSLGTIATDWTNDVLFGEIIQGNVSNFLASLN
                     VAEWLQGLVVDGLIGGVGAVLGFVPQIMLLFLLLSILEDCGYMSRVAFIMDRIFRKFG
                     LSGKSFIPMLISSGCGVPGVMSTRTIENDRDRKMTIMLTTFIPCGAKIPIIALFAGAL
                     FGGASWVAPSMYFLGIAMIIICGIILKKTSLFAGEPSPFVMELPQYHIPSAKGVLIHM
                     WDRGKAFIIKAGTIIFVACGVIWFLQSFNWSLQMVDAGDSILASLGNIVAPIFAPLGF
                     GNWQSSVATVTGLVAKENVVGTFGVLFGISDATEQDPTLLASVASMFTVASAFAFMAF
                     NMLCAPCFAAIGAIKREMGSWKWTWITLGFQTLTAYIIALLINQVGSLVLGTGGSIAG
                     AIISIFIAVAVVFVVLTYSNKNMKKEKMGKLSYMKN"
     gene            6125..6277
                     /locus_tag="KRO40_002892"
     CDS             6125..6277
                     /locus_tag="KRO40_002892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FeoB-associated Cys-rich membrane protein"
                     /protein_id="HBH2093702.1"
                     /translation="MATFIIAAIVVVLMALAVMYMVKNSKKNGSSCGCGCSGCSSSKS
                     CHSAKR"
     gene            6457..7167
                     /locus_tag="KRO40_002893"
     CDS             6457..7167
                     /locus_tag="KRO40_002893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBH2093703.1"
                     /translation="MFKFDVTNELMCIARGSGKFFAKKGAMVAFKGNFNFEKLLLGPS
                     NGGGLGRALLGHVQRSLTGEQMPIMVVEGEGEIYLAQNAYHVDVISIDPGDSIYVESE
                     NLLAFSEQLNYSVKLIGSGVISQKGLFTTHLVNKTGQNQDVAIITDGNPLILEGPCCV
                     DPDALVAWTGREPYPKVSKLSWKTFIGQTSGESYHMEFVEPGQIVIIQPSERLSGLKT
                     DSTPSDRMSSGGLRLGID"
     gene            7252..8022
                     /locus_tag="KRO40_002894"
     CDS             7252..8022
                     /locus_tag="KRO40_002894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093704.1"
                     /translation="MFEKIHKRLKGYYIFLIILILWKIVCVLGIWSSYILPPPEIVLD
                     TFIKMIYDGSIFLNVYASVRRILIGFLISSLMAIPLGVLFGANKKMYEYFKPLFEFMR
                     STPPLALVPMLILWFGIGEESKIIIIILASFFPIFLNTLKGIKNCDNKLIEVGKSFNL
                     SKKRIFYKIIIPNSMLDIVVGLSLGLGYSFRAIIGAELIAASSGLGYLISDGKDMSRT
                     DVVLVGIFVIGFLGILSDYLFSKIITKFSKGKQVDLNG"
     gene            8015..8746
                     /locus_tag="KRO40_002895"
     CDS             8015..8746
                     /locus_tag="KRO40_002895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093705.1"
                     /translation="MVRSGFLLENIYKKYLVDNKEHLVLDNISLNISSEEITVILGES
                     GCGKTTLLRILAGLENATSGNVYFFNNDKKCTPKVGMVFQESRLMPWLNVSENILLHT
                     EKDNRNKVDLDKYLKMMKLEKFKNSYPNELSGGMAHRVSIARALSFNPDILLMDEPFA
                     ALDYFTRRKMQKEVVNIHKNTKKGVVFVTHNIEEAMEIAKKIIVFSKNKRIKQFSVED
                     EYNRDLTKNYYINLKKEILRELGEF"
     gene            8780..9739
                     /locus_tag="KRO40_002896"
     CDS             8780..9739
                     /locus_tag="KRO40_002896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2093706.1"
                     /translation="MTSLIMVLVGTVGCSTTNDKKDEPAKKEASLPKEINLTYVKSPL
                     NVPSILEKKDDLFGKEFKKDNIKVNFHELTTGPEQTQALAAGELDFLHALGGTSAIIA
                     ASNGVGLKITNIYSRSPKGYMLITNNDNIKSIKDLKGKKIVGPKGTILHQLLIAALAK
                     EGYTIDDVEYVNMDIPSAASALESKSADVAMLAGPVALKTINSGAKMIVNGEGLVSGI
                     IVTAVSDDFAEKYPELVKRFMKVHEETLKYMNENKDEVMDVVSKEVGLSLDETKEMYS
                     WYDFSSKITDKDIKELEDTQEFLMSNGMQQKKINIKDMLYNQN"
     gene            complement(9837..10433)
                     /locus_tag="KRO40_002897"
     CDS             complement(9837..10433)
                     /locus_tag="KRO40_002897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3793 family protein"
                     /protein_id="HBH2093707.1"
                     /translation="MSCCNSQFCCKNKIESSYIKWLLEVLGPVFLGSKPAEIINISFT
                     DVNREEKINDIYKYLYKCKKIDFIVIDKEKKGLKILFVNKKALSEKLKCKKTVNFLKF
                     LGYKQNTNVNAYLEHLVDKLKSDVFPDEIGIFLGYPLKDVIGFMGYSNYEVSMIKYWK
                     VYGDTKQSEDTYSKFLLHRKKMRKLLDYISVDKIVSCF"
     gene            10679..11278
                     /locus_tag="KRO40_002898"
     CDS             10679..11278
                     /locus_tag="KRO40_002898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093708.1"
                     /translation="MKLKRTLFVGLALVLAIGITACTKNNEKPSENTGKNPNESVNNN
                     EGYMNYYSTSYNDYIAGLNRYSIYDTPESINNQFKDKEYPGNEKYLSDVKAAYKDSRD
                     KIQSFVTSLKKDGKTEDTELKKMNDDLIAEGERLVKDIDKRIEKLDKVSDEDMKKGQN
                     DFIKLVHGTEDVGNDIGSGFRKMIKDMNDRLGITGNNKK"
     gene            complement(11448..11915)
                     /locus_tag="KRO40_002899"
     CDS             complement(11448..11915)
                     /locus_tag="KRO40_002899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093709.1"
                     /translation="MENDTIKADDILNYCLSNLDDVVLMDSWGERAIYYNPNGVLKRG
                     VYVLTIKEKDSNNDKGSLVSRPNVYRVNIGLKKETFIEMFGYIPKRPGVGQIVDMDFD
                     FTKLDTIMPHPIYSWMGWICVLSPTEKTFENFKTLIGESYNFAKQKFKKRKNK"
     gene            12026..12970
                     /locus_tag="KRO40_002900"
     CDS             12026..12970
                     /locus_tag="KRO40_002900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBH2093710.1"
                     /translation="MSRAERLIELMITINAKRSFTAGELAEEFSVSKRTILRDLQVLE
                     SIGFPLYSKVGAAGGYHVLKERILPPIAFSESEVKSIFFAYQSLEYYNDLPFEQETIS
                     VLKKFLNCIPNDIQYNIENIRRKFVFWTPDRHCSTPLLKELFNIVMNEFTIKIEYSSK
                     QKNSVRTIVPIGLYAMNGLWYCPAYCIKSESIKEFRVDRIVKILSIENLSSKKYKVLS
                     SIHDYLKNMEVGTDYHIKINLTDEGVKRCETEFLLARGLKILSKGGYIDMYIPKSTLN
                     WVAEYFLTFGKNATIIEPIELKHLIKSKVLELYNHHCI"
BASE COUNT         5047 a         1384 c         2288 g         4366 t
ORIGIN      
        1 ttataagaaa ctaatattag atagtgtatt taaatagata ataataaatt cattatagtt
       61 gaataagaat attatatgag aatattgcaa tttgatatat ttaccattac aataaaagta
      121 gttacaacta gaaaaccaaa taagttaaag taagttggca aattggaggt ttttaaatat
      181 gaaagcattt aaaaagcact tcttgatact ttctttgata tttttactta ttatatcatg
      241 ttttaacaat atactatgct ttgctgatga gtctgaaaat tcaaaaaaaa taagagttgg
      301 atattgtgat gactacggaa taatatcctc atcaaaagag cattcttata caggatatgg
      361 ttatgattat ctaagagaaa tctcaaaata tacaagatgg gaatatgaat ttgtaaaagg
      421 gtcttgggaa gaatgtttag acagactaga aaagggtgaa atagacttac tcggaccttt
      481 acagaagaat gatgaaagaa ataaactatt taattttcct aaactaagtt caggatatga
      541 atatagtgca ctatatacaa aggatagtaa caataatatg ttttatgaag atataagttc
      601 ctttaaggga atgagagtag ctgtacttag aggaaacttt cataatactg catttgagaa
      661 gtatagagaa gaaaataatt tttcagttga atatatatac tgtaattcta ttgatgaatt
      721 aattgagtcc gtcaatgaaa aaaaggcaga tgcatttgtt tgtggaagta ttataaatgc
      781 taaaggaatg aaaatagtta gcaaattttc agtagaacct ttttattttg ctactgcaaa
      841 agataaacct aatttagtaa aagaattaga ttatgcttta aaagaattaa aaataaatga
      901 tatgtattat gagttggaat tatataaaaa atatttcaaa agagaggtca ataattccat
      961 agcatttact cggcaagaaa tgaattttat taaagcaaac ccaaaactta ctatggtata
     1021 tgattcagag tggtctcctg tagagtatta tgataaagaa agcaattcat ttaaaggtat
     1081 aagttccgat ttaatgtcaa ttatatcaaa aaaatgtggt ataaaatttg aatatattaa
     1141 aacaaaaaat tataatgaga gtcttgatta cataaaaagt ggtaaggcaa ctatgctatg
     1201 tggctcaatc aatgaaaatg ataaggcaaa acgatttaat atgaaattga caaatccata
     1261 cataaatatt ccaatgatta tggtaggaaa attggatacc aatctcaata atgatttaaa
     1321 tattgcttta actagtagtt ataagtctat tgattcttat atagaaaaga gttttgaaaa
     1381 tgctaagaca acatcttata agagtgtaga aagttgtcta aacgctataa atgaaggtaa
     1441 agcaaactta atgatactta gctcttatca gtttgatgaa cttttaagag aaggaaagag
     1501 tgagaattta tctgttatat ctgttttaga tacaagctat gggatgcgta taggggtatc
     1561 aaataaaact gaccctatat tagtgtctat tttaaataaa tcaatagaca aaattactga
     1621 agaagaatta agtgattgta tatattctaa tactattgac aaaccttata aagtaccatt
     1681 tggtgtgatt tttaaagaat attcaataca aattatttct tttgtatgta ttttattctt
     1741 aattgctatt aaatatataa tttataataa aaagaagaaa gaggattatc taaggaagat
     1801 agcatataca gacccattga caggagcaga tagtatagat aaatttaaaa taaattctaa
     1861 taaactgttt gctaaaaata atccagaaga atatgcgttg ttttatatag atgttgacaa
     1921 atttaaatat ataaatgata tgtttggata tgatatggga aatgatactt tgatacatat
     1981 atcaaatact attgcaagtg aattaaagga agatgaaatt tttgcaagag tttctgctga
     2041 ccattttgtt cttcttatta agtataagac agatgatgat attaaaacaa ggttaaacaa
     2101 tatttacaat aaggttcaaa tacttagtaa tcctaaaata aactattata aattgatttt
     2161 agattgtggt atatataaaa taagtaaaag tgataatgac ataaatacta ttatggatag
     2221 agctaatact gcaagaaaaa ctataaaagg tggtcataaa aattcatttg ctttttacga
     2281 taaggaaatg cacaaaaaaa tattaaaaga gaaagaaatt gaaaattcaa tggtagatgc
     2341 tcttaataat ggagaattta ttgtttattt tcaacctaaa tatagtcttt cagattatca
     2401 aattataggg gcagaggctc ttgttcgttg ggataatcca caaaaaggtc taataccacc
     2461 aatagaattt attcctgtat ttgagaggaa tggttttatt gtaaatattg atttctatgt
     2521 atttgaggaa gtgtgtaaaa agattagaga atggatggat gaaggacaaa aagtagtacc
     2581 tatatctgta aacttgtctc gaatgcattt tgtaaatagt aattttatag agaagtttaa
     2641 attaattgta gataaataca aaattccgac aagacttata gaattagagc taacagaaac
     2701 agcagtatta gataatatag aaggattact tgatacaatg aacaatttga aagaaaaggg
     2761 gtttgtaatc tctatggacg attttggtac aggatattcc tctcttaatc ttttaaaaga
     2821 attgcctgtt gatatattaa aactagatag agcatttttt acagaaaaag atgagagtaa
     2881 taatgaaaaa attgttatat ctaatgtcat taaaatggca aaggaactga aaatgaaagt
     2941 aatatcagaa ggtgtagaga ctatttcgca agtagaattt ctaaagcaga ttgggtgtga
     3001 tatggtacaa ggatatttgt tttctaagcc aatgcctgta aaagagtttg aaaaaatcgc
     3061 ttttaaaaaa gaataaagca atgtgtaaat aatgacatat ataataaagg tgctttaata
     3121 ttagttgagt atactatttt agagcatctt tatttttgta ttaattttta cgattttatt
     3181 aataaaataa atcaaatgag aaaaaaaatc aaaagaatac aataatcact tgcaaaaaat
     3241 atactattgt gatagactta aatcaaaatt aggaattgta aaaagaagga aaaaatagga
     3301 tattatttta atagattaag atttaaggta ttgtaattta tatataagat aacgattgct
     3361 tgtaaattta aattacttta agaggaggga tattatatga tgccattgat attatcaaat
     3421 acaggtgaag aagtagttat aaagaaaatt tcgggaagtg ataagacgag gactttttta
     3481 aatagtatag gttttgtagt gggtacaaat gttaaaatag tttctaagat agatggtaac
     3541 ttaataatag acgtaaaaga tactagagtt gcattagata aaaaaatggc aagtagaata
     3601 ataatatagg gaggtaatga catgaacaga ctgaaggata ttaagtgtgg agagactgta
     3661 aaagtcaaaa agttagaagg agaaggagct acacgaagac gtataatgga tatggggatt
     3721 acaagaggtg ttaatatatt tataagaaaa gtagctcctc ttggtgaccc aattgaggta
     3781 acagtcagag attatgaact atcaattcgt aagtcagatg cagaaaaaat tattgtggaa
     3841 taataaagat taattagagt agggttaatg taatcatata atgagaatga ttttctgtat
     3901 cacaaacagt gatgtattta aataataatg gagggaatgg aaatgtcaat aaaaataggt
     3961 ctcataggaa atcctaactg tggtaagaca acaatgttca atgggcttac aggctcatca
     4021 caatatgttg gtaactggcc aggagtaaca gttgaaaaaa aaggtggaaa attaaaagga
     4081 aataaagatg tggaaatagt agatttacca ggtatttatt ctttatctcc atatacatta
     4141 gaagaagtag ttacacgtaa ttttatgcta gatgataagc cggatgcagt aataaatatt
     4201 gtagatgcat caaatataga gagaaattta tatcttacaa ctcaagtttt agagctaggt
     4261 ataccgaccg ttatagctct taatatgatg gatattgtaa ataagaatgg tgataagata
     4321 aatattaaag aactatctga agttataggt tgcccagtgg tagaagtaac agcagttaaa
     4381 ggtcaaggaa ttatggaagc tgctgaaaag gcagttgaac ttgcaagtag taacaataaa
     4441 ttaaatttca aattaccctt tgttgatgaa agtaaggatg caatagaaaa aattgaaaaa
     4501 ataatagaag aaaagactcc atatatagat gtagaaacac gctggttagc tataaagcta
     4561 tttgagagag atgaaaatgt tatacaaaaa cttgatattt ctaaaacaat attgaatagt
     4621 attgaagaaa taactagaaa ttgtgaagat gaattggatg atgatagtga aagtataata
     4681 acagccaatc gttatgaatt tattagttca ataatttcaa gtataataaa gaagaatcga
     4741 aaaggtaagg aaactgtatc agataagata gataagattg taacaaatcg tatactagca
     4801 ttacctattt ttgcacttat aatgtgggga gtttactata tagcagtaag ttcattgggt
     4861 actatagcaa ctgattggac aaatgatgta ctgtttggag aaattattca aggcaatgta
     4921 agtaattttc tagcttcttt aaatgtagca gagtggttac aaggacttgt agttgatggt
     4981 ctaattggtg gagttggagc agtactagga tttgtaccac aaatcatgct tttattctta
     5041 ttattatcaa tattagaaga ttgtgggtac atgtcacgtg tagcttttat aatggataga
     5101 attttccgta agtttggtct ttcaggaaaa tcatttatac caatgcttat aagttcaggt
     5161 tgtggagttc caggagttat gtcaactcgt actatagaga atgatagaga tagaaaaatg
     5221 actattatgt taactacatt cattccatgt ggagctaaga ttccaataat agcattattt
     5281 gcaggggcat tatttggagg tgcttcatgg gtagctccat caatgtattt cttaggtatt
     5341 gcaatgataa tcatttgtgg aattatatta aagaaaacta gtttatttgc aggagaacca
     5401 tctccatttg ttatggaatt acctcaatat catattccaa gtgcaaaagg tgttttaata
     5461 catatgtggg atagaggaaa agcatttata atcaaagcag gaacaattat atttgttgct
     5521 tgtggagtaa tctggttctt acaatcattt aattggtcat tacaaatggt agatgctgga
     5581 gatagtatat tagctagctt aggaaatata gttgcaccaa tatttgctcc tcttggattt
     5641 ggaaattggc aatcatcagt agcaacagtt acaggtctag tagctaagga aaatgtagtt
     5701 ggaacatttg gagttttatt tggtatatca gatgcaacag agcaagaccc aacacttctt
     5761 gcttcagttg caagtatgtt tacagtagct agtgcgtttg catttatggc atttaatatg
     5821 ctttgtgcac cttgttttgc agctattgga gccataaaaa gagaaatggg ttcatggaaa
     5881 tggacatgga ttacattagg attccaaact ttaacagcgt atataattgc tcttcttata
     5941 aatcaagttg gaagtttagt tttaggtact ggaggaagta ttgctggggc aataatatct
     6001 atatttatag cagtagcagt agtctttgta gttttaactt attcaaataa aaatatgaaa
     6061 aaagaaaaaa tgggtaaatt aagttatatg aaaaattaat tcatataaat aaggagtgat
     6121 gaatatggct acatttatta tagcagctat tgtagtagta ttaatggcac tagctgtaat
     6181 gtatatggtt aaaaattcaa aaaagaatgg tagcagttgt ggatgtggtt gttctggatg
     6241 ctcaagtagt aagagttgtc atagcgctaa gagataaata ggataagagc ctgataaaaa
     6301 gttaaattgc tttattatca ggttcttatt ttttgtataa ataacaaatt tcatatttga
     6361 agtaggttag actatgctgt aattttactg tataattata tataaatata tgattaggag
     6421 ggattattgc taaattaagc aatataagtg aatattatgt ttaaatttga tgttacaaac
     6481 gagcttatgt gtatagcaag gggaagtggt aaattttttg caaaaaaagg tgctatggta
     6541 gcctttaaag gaaattttaa ttttgaaaaa ttgctgttag gtccaagtaa tggcggtgga
     6601 ttgggaagag cattattagg tcatgttcag aggtcattga caggagaaca aatgccaata
     6661 atggtggttg aaggtgaagg tgaaatttac ctagctcaaa atgcttacca tgtagatgta
     6721 atatcaattg acccaggtga ttccatttat gttgagagtg aaaacttatt ggcattttct
     6781 gaacaattaa attacagtgt aaaattgatt ggttcagggg taatatctca aaaaggtctt
     6841 tttactacac atttagtaaa taaaacaggt caaaatcaag atgttgctat aataacagat
     6901 ggtaatcctc taattcttga aggaccttgt tgtgttgacc cagatgcatt agtagcttgg
     6961 actggaagag aaccatatcc taaagtatca aaactatcat ggaagacttt tattggtcag
     7021 acttcaggag aatcttatca tatggaattt gttgaacctg gacaaatagt cattatacaa
     7081 ccatctgaaa gattgtctgg cttaaaaaca gattctacac cttctgatag aatgagttca
     7141 ggtggattaa gacttggcat agattaaatc ttatgatata gcttaattat tatttaagat
     7201 attaaaaaat aaaaagggta gcagggatag atatgttaaa aggagtttta tatgtttgag
     7261 aaaattcata aaaggcttaa aggatattat atttttttaa taattttaat tttatggaag
     7321 atagtatgtg ttttgggtat atggagtagc tatattctgc ctcctcctga aatagtctta
     7381 gatactttta taaaaatgat atatgacggt tctattttct taaatgttta tgccagtgta
     7441 agaaggatat taataggttt tttaataagt tcattgatgg ctataccact tggagtttta
     7501 tttggagcaa ataaaaaaat gtatgaatat ttcaaaccac tatttgaatt tatgcgaagt
     7561 acacctccac tagctttggt gccaatgctt attttatggt ttggtatagg tgaagaatct
     7621 aaaattataa ttattatttt ggcatccttt tttccaatat ttttaaatac attgaaaggt
     7681 ataaaaaatt gtgacaataa attaatagaa gtaggtaaat cttttaattt atctaaaaag
     7741 agaatttttt ataaaataat aatccctaat tctatgctgg atattgttgt tggacttagt
     7801 ttagggcttg ggtatagttt tagggctata attggagcag agcttattgc agcttcttca
     7861 ggactaggat atttgatttc tgatggaaaa gatatgtcta gaactgatgt tgtattggta
     7921 ggaatttttg ttattggatt tttaggtata ctttcagatt atctattttc aaagataata
     7981 acaaaattta gcaaagggaa gcaggttgat ttaaatggtt agaagtggat ttttgctaga
     8041 gaatatatat aagaaatatt tagttgataa taaagagcat ttagttcttg ataatatatc
     8101 tttaaatata tctagtgaag agataactgt tatattaggt gaaagtggat gtgggaaaac
     8161 aacgctactt agaattttag cagggcttga aaatgctact agtggaaacg tatatttttt
     8221 taataatgat aaaaagtgta ctccaaaagt aggaatggta tttcaagaaa gtagacttat
     8281 gccatggctg aatgtaagtg aaaatatact tttacatact gaaaaagata atagaaataa
     8341 agttgattta gacaagtatt taaaaatgat gaagcttgaa aagtttaaaa actcatatcc
     8401 aaatgaatta tcaggaggaa tggctcacag agtaagtata gcaagagcac tttccttcaa
     8461 tcccgatatt ttgctgatgg acgaaccatt tgcagcacta gattacttca caagaagaaa
     8521 aatgcaaaaa gaagttgtaa atatccataa aaatactaaa aaaggtgtag tatttgtaac
     8581 tcacaatatt gaagaagcta tggaaatagc aaagaaaata attgttttta gtaaaaataa
     8641 aaggattaaa caatttagtg tcgaagatga atataataga gatttaacta aaaactatta
     8701 tataaacttg aaaaaagaaa tattaaggga attgggggag ttttaattga ttaaaagaaa
     8761 caaaaagatt ttagcagtaa tgacatcttt aataatggtg ttggttggga ctgtaggatg
     8821 ttcaacaaca aatgataaga aagatgaacc tgcaaaaaaa gaggctagtt tacctaagga
     8881 aataaattta acttatgtaa aatcaccact taatgttcct agtatattag aaaaaaagga
     8941 tgatttattt ggaaaggaat ttaaaaagga caatataaaa gtcaatttcc atgaattgac
     9001 aacaggacca gagcaaactc aagcattagc agcaggtgag ctagactttt tacatgcatt
     9061 aggaggaacg tctgcaataa tagctgcatc aaatggtgtt ggtcttaaaa ttacgaatat
     9121 ttatagccgt tcaccaaaag gatatatgct tataactaat aatgataata ttaaatctat
     9181 aaaagactta aaaggtaaaa aaattgtagg tccaaaaggg actatacttc atcaactgtt
     9241 gattgctgca cttgctaaag aaggctatac tatagatgat gttgaatatg taaatatgga
     9301 tattcctagt gctgcttctg cattagaaag taaaagtgct gatgtagcaa tgcttgcagg
     9361 tccagtggca ttgaaaacga taaattcagg tgccaaaatg attgtaaatg gagaaggatt
     9421 agtaagtgga ataatagtta ctgctgtaag tgatgacttt gctgaaaaat atcctgaatt
     9481 agtaaaaaga tttatgaagg ttcatgaaga aactttaaaa tatatgaatg aaaacaagga
     9541 tgaagtgatg gatgttgtat ctaaagaagt tggtttatct ttagatgaaa caaaagaaat
     9601 gtattcttgg tatgacttta gttctaaaat aacggacaag gatataaaag aattagaaga
     9661 tacacaggaa tttttgatgt ctaatggaat gcaacaaaag aaaataaata ttaaagatat
     9721 gttgtacaat caaaattaga atactttaaa atattaaagt ggaaaataca cccttattta
     9781 ttatggaaac tgtatggtaa aagagggtgt atttttatta ttatacaaaa acacaattaa
     9841 aaacagctta ctattttatc tacacttatg tagtctagta attttctcat tttcttacgg
     9901 tgaagtaaaa acttcgaata tgtgtcctcg gattgttttg tgtcaccata aactttccaa
     9961 tatttaatca tagaaacttc ataattacta tatcccataa atccaatcac atctttaaga
    10021 ggatatccta aaaaaatacc tatttcatca ggaaaaacat cactcttaag tttatctact
    10081 aaatgctcta aataagcatt aacattcgta ttttgtttgt atcctaaaaa ctttaaaaag
    10141 tttactgttt ttttacattt taatttttct gataatgctt ttttatttac aaataagatt
    10201 tttaatccct ttttttcttt atcaataact ataaaatcta ttttcttaca cttatataga
    10261 tatttataaa tatcattaat tttttcctct ctatttacat cagtaaacga aatatttatt
    10321 atttcagcag gtttagagcc taaaaagact ggacctaaaa cttctaaaag ccattttata
    10381 tatgatgatt caattttatt tttacaacaa aattgtgaat tacaacaaga cataaaagat
    10441 aacctccttc aaatgaaaat taatatcaag taattagatt atactatgaa tgataatcaa
    10501 tatcaatgat aaaattataa tttttttatt taattattta ttcattatga tttccaaaaa
    10561 aataaattat aacttgttta attttagtaa ataaaatata aaaatataga aatactaaat
    10621 taagaaagaa aattattaaa attttttata gtataaaaca tctaggaggg taataaaaat
    10681 gaaattaaaa agaactttat ttgtaggatt agcactagta ttagctatag gtataactgc
    10741 atgtactaaa aataatgaaa aaccaagtga aaatacagga aaaaatccta atgaatctgt
    10801 aaataataat gaaggatata tgaattatta ttcaacaagc tataatgatt atatagcagg
    10861 tctaaataga tattctattt atgatactcc agaaagtata aataatcagt ttaaagataa
    10921 agaatatcca ggaaatgaaa aatatctaag tgatgtaaag gctgcatata aagatagtag
    10981 agataaaata caatcatttg taacatctct taaaaaagat ggtaaaacag aagatacaga
    11041 gttaaagaaa atgaatgatg acctaatcgc tgaaggggaa agattagtaa aagatataga
    11101 taagagaata gaaaaattag ataaggtatc tgatgaagat atgaaaaaag gtcaaaatga
    11161 ctttataaaa ttagttcatg gaactgaaga tgttggaaat gatataggta gtggttttag
    11221 aaaaatgata aaagatatga atgatagatt aggaataaca ggaaataata agaaataata
    11281 gaataaatag ttttgaaatt tgaaataaat tatttgagat atagcgaagc cttataaata
    11341 atacattttt tggcttcgct tttttgcatg ttattaagat attaattttt atcttgtaac
    11401 cttaatattt ttattataat ttatttagag gttattttca cacgttttta cttgtttttt
    11461 ctctttttaa atttttgttt tgcaaaattg taagattctc ctattaaagt tttaaagttc
    11521 tcaaatgtct tttcagtagg gcttaggaca catatccatc ccatccatga gtagatagga
    11581 tgtggcatga ttgtgtccaa ttttgtaaaa tcaaaatcca tatcaactat ttgacctaca
    11641 cctggacgct ttggaatata tccaaacatt tcaataaaag tttctttttt taatcctata
    11701 ttcacacggt atacatttgg acgactaact aacgaacctt tatcattatt actgtctttt
    11761 tccttaatgg taagaacata tacccctcgc tttaaaacac cattaggatt gtagtaaatt
    11821 gctcgttccc cccaactatc cattagtaca acatcatcta agtttgatag acaataattg
    11881 agaatatcat cagccttaat agtatcattt tccataaagt atcaatccct tctttcttta
    11941 ctattattat tgctttagat gcaagaatat cttatcatat aatagtgaca attattgtca
    12001 ctatatttaa attaggagta taaatatgtc aagagctgag cgtttaattg aactgatgat
    12061 aacaataaat gcaaaaagaa gttttacagc aggagaatta gcagaagaat tttctgtatc
    12121 aaaacgtact atactaagag atttacaggt gctggagagt attggatttc cattatattc
    12181 aaaagttgga gcggctggtg gatatcatgt acttaaagag cgtatacttc caccgattgc
    12241 attttcagaa agtgaggtaa aatctatatt ctttgcatat cagtcactag aatattataa
    12301 tgatttgcca tttgagcaag aaactatttc tgttttaaaa aaatttttaa attgtatacc
    12361 aaatgatatt caatataata ttgagaatat aaggcgtaaa tttgtttttt ggacaccaga
    12421 taggcactgt tcaacaccat tattgaaaga attgtttaat atagtaatga atgaatttac
    12481 aattaaaatt gaatattcat caaagcaaaa aaatagtgta cgtaccattg ttcctattgg
    12541 tttgtatgcc atgaatggac tttggtattg tccagcttac tgtataaaat cagaatctat
    12601 taaggaattt cgtgtagaca gaattgtgaa gattttgagt atagaaaact tatcaagtaa
    12661 gaaatataag gttttatctt ctatacatga ttatcttaag aatatggaag taggtacaga
    12721 ttatcatatt aaaattaatt tgacagatga gggagtaaaa cgttgtgaaa cagaattttt
    12781 gttggcaaga gggttgaaaa tcttgtctaa aggtggatac atagatatgt atataccaaa
    12841 atctacactt aactgggtgg ctgaatattt tttaactttt gggaaaaatg ctacaataat
    12901 agaacctata gaacttaaac atttgataaa gtctaaagta ctagagctat ataatcatca
    12961 ttgtatttaa attattttat ttaatagtag gatagagttt ggataaaatg ttaattttct
    13021 taatttactt tacagatgat ttagatagat tgatgttatt taatttattt cttataatga
    13081 tgttc
//
LOCUS       DAEQCW010000102        12811 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.103, whole genome shotgun sequence.
ACCESSION   DAEQCW010000102 DAEQCW010000000
VERSION     DAEQCW010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12811)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12811)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12811
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.103"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            106..294
                     /locus_tag="KRO40_002901"
     CDS             106..294
                     /locus_tag="KRO40_002901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HBH2093711.1"
                     /translation="MAKVCSVCGKGKVSGNQVSHSNKHNKRTWSANLRSVRAIIDGAP
                     KRVKVCTRCLRSGKIERA"
     gene            complement(454..606)
                     /locus_tag="KRO40_002902"
     CDS             complement(454..606)
                     /locus_tag="KRO40_002902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate translocator"
                     /protein_id="HBH2093712.1"
                     /translation="MRNNKSKVLLGILCLATGMAVILSMLLPGWIWSALTALILIGCG
                     ALLFFC"
     gene            complement(704..1180)
                     /locus_tag="KRO40_002903"
     CDS             complement(704..1180)
                     /locus_tag="KRO40_002903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBH2093713.1"
                     /translation="MNLKRSNEKREEYRRMYSDKESFLSLIQNFTSVSIAKELTLKNI
                     ELETSFICEYKGKEVDIIYKVFSKSGKVSHYIVLEFQTEMDTEIVPRLKSYREQIWKS
                     FIMKKSLEEIEDKNFKLPKVIPVVLYSGPERLSRKKGILDIVESISEFSNNSSMKN"
     gene            1399..2160
                     /locus_tag="KRO40_002904"
     CDS             1399..2160
                     /locus_tag="KRO40_002904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2093714.1"
                     /translation="MEYTVQKLSKLAGISTRTLRYYDEIGLLKPLKINSSGYRIYGQN
                     EVNKLQQILFYRELGINLENIKNIINSPNFDSLSALKEHHNKLLAKRKQIDLLIENVT
                     KTIALKEGKYTMTDIEKFEGFKEKMIDENEKNYGTEIREKYGKDIIDTSNKKLKNMSK
                     QDYENWQNLNIEIISKLKKAFKTGDASSELAQEVAKLHHKWLCYTWNTYSKEAHSSLA
                     QMYVYDERFTSYYDREQPGLAKFLRDAIVIYTRDK"
     gene            complement(2420..4348)
                     /locus_tag="KRO40_002905"
     CDS             complement(2420..4348)
                     /locus_tag="KRO40_002905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBH2093715.1"
                     /translation="MHKRLLTLFKLLNESDDKITCKTLSNHLKVSERTIRNDITSING
                     TLEKNGAIIKIKKGEGYYIDILNLALYQQYLALISDDIMDSSEIPDSPIERNQYILKY
                     ILYNNTYIKLEDLANSLYVSKFTILNDIKRIKPILSKYNLILVSKPYYGVKVEGKEID
                     IRRCISNNMINRNFENYIIGITDREIELFNNVDLIELQRVVLSEINKFNINFLDFNLK
                     NFIIHLAITVSRILDGYCLDNVLDVVLTDFQSNTTVENIFNYIESKYTIIISKADRVY
                     LYNHFITKSSLLDNVSNRVDTKIIEYVEEILEVINNQYTFDLRNDSVLFDDLVLHFKS
                     ILNSKSYNLNKVNPLINTIKSNYPLAFEITLNAIEKVFKNSIYSLTEDEIGYVSLHIG
                     AGIERFFQSNIKCKNVVLVCGSGYGSSRLLEVQLNKVFHDKINILQCLSFNQFLASEL
                     SDVDIIISTIPLNHDSIPIVLVDLKLLKKDIENISKSITNNSHIYSNLLDNFFDKNLF
                     IVNPKIKDKDELIKLMCNKLTQSEIVFPSFAESVFYRESLSSTNIDDFLAIPHPMELS
                     SIRTKICISILNEPIYWSENSTVKLIMMLAINKDDYIKINSIYDILLKIIHDNDIRDS
                     ISNCNDFDNFLSIIKSIV"
     gene            4582..5034
                     /locus_tag="KRO40_002906"
     CDS             4582..5034
                     /locus_tag="KRO40_002906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBH2093716.1"
                     /translation="MVLQEKYIFIDKDLKSKEEVLNFIADSAYILGITTNKEALLKDL
                     LKRENEFPTGIKDGFAIPHTKSVNVKEASILYIKTTNELEWKTLDDSKVRYVFSLLAP
                     HKNEGNIHLKTLSKLATCLMEDDFTSEVKNASDASHLVKYITNKMKEE"
     gene            5037..5345
                     /locus_tag="KRO40_002907"
     CDS             5037..5345
                     /locus_tag="KRO40_002907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBH2093717.1"
                     /translation="MKIVAITSCIAGLAHTPMAAKALEQAASKMGHEIKVEQQGAMGR
                     VNTITKEEAQDADFILIASDQTISGMERFDGKKVIKVKIGIALKKPEAVLTKCIEAIS
                     "
     gene            5459..6565
                     /locus_tag="KRO40_002908"
     CDS             5459..6565
                     /locus_tag="KRO40_002908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBH2093718.1"
                     /translation="MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAV
                     GITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVLAGFIAFSIGEKPAMGAGFIGGL
                     IASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMS
                     VVLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNAL
                     LLEGIYLPAILVNCAIVIPPLGYGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAI
                     PFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFISIGSGWAYLVGAIF
                     GALVIAILSTTLVDFNEDETTENTEFDEIELDIM"
     gene            6640..9318
                     /gene="mngB"
                     /locus_tag="KRO40_002909"
     CDS             6640..9318
                     /gene="mngB"
                     /locus_tag="KRO40_002909"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBH2093719.1"
                     /translation="MKKTKVHVVPHSHWDREWYFTTSRSKIYLMKDFQDILDILEEKE
                     DFKYFTMDAQASLLDDYLKWRPQDKYRIRDLVQRRRLVIGPWYTQTDQLVISGESIIR
                     NLYYGIDRCNEFGEPMRVGYVPDSFGQSAQMPQIYRGFGIDSSLFWRGVSDDMVDTTE
                     FIWKGSDGSKVLAVQIPFGYYYGGNIPEDDSDLKEYLKDIIVKLKVKASTNNVYFPNG
                     FDQAPIRKNLPDILKKANEIDNENEYEISDIENYIDSVRNERNEFTELKGEFLNAKHM
                     RIHKSIFSSRSDLKIMNNKLENYITNVLEPLLTLSYSLGNEYPHLVIKDIWKLMFENA
                     AHDSIGSCNSDTTNEDVYTRYKQARDLSINLLDLHMRLISTQIKNNNEEITLTVFNGF
                     PEVRNEVVEFDTYIPGQDFVIKNKNGKILNYIIKEKEDITNYILTQTIRLNPSKKIYI
                     PKTVYRAKIALSVKDIPPMGYTQLVFELDTKNKCEIETSNCKEIENKYYKITANKNGS
                     LEILDKESNKTYKNQAVIEDNGDDGDSYNYSPPRKDIYVSSLDSVSSVEVLKSNIQEE
                     MILKYSLTIPASLEERAIGKVSVKMPVTMKITLEPKEQIIKFNVNIKNNQALSHRVRV
                     LFNTEIASKFSIADQQFGIIQRPTVLEKDLALWKRDNYSWQEKPITIEPMQSFVTLED
                     GQRGIALITGCVREYQIVGDNLDTIALTLFRSFGYMGRENLLYRPGRASGEKIIATPD
                     AQLLKELNFDFGLYIYNNKFDEANVANTAKRFLTPIQIYEYADFLNGRLIFAFNDEKQ
                     IYENEFSLMNVNNSNFTVSAIKKEEKGDGIVVRIFNGMKNEDAKGSLNINKNVNDAYS
                     AMLDEIYDNTSKLKVNTKTVEVNSLSHCKVQTIVIK"
     gene            complement(9635..11968)
                     /locus_tag="KRO40_002910"
     CDS             complement(9635..11968)
                     /locus_tag="KRO40_002910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2093720.1"
                     /translation="MDTKLKKFKDKYIVTIIVFILMLSASLGMISQYSTIQASAKGGA
                     ENPFEQESFVDSIYKGSYVLYHNMKEEQEGKMIQPSKLFINEETMNYIKNVSKEKDTY
                     DGSETYYTDDSINADFNENFENWEHFIKASGKNLKYYLVDKESNFEFFNDNKELGVLD
                     TTKNDASKENSDENQSKNTEMNDEERQKQITDIKENYRFYVVMNFDKDGKVNIVDSYG
                     VNQKIINQMLLSKAREDLMDTSLGGNSISYKLSPIKNITLVYAVPKVISKGDSVEYGY
                     GNTYFDDGIISYISNVENNSYYKISGMILKIILAIVVIVALAFPYRKSKELLGFDTLS
                     RIPLEILFIALDIIQGLVDLYPTVIISNTLSGNYVEYLINNDISAKMASILVSLMNLT
                     YWFVIFSIIFVFIILLKHILNVGIREYFTKHTVTGMFFVWLKKAGKTVINQIRTINLK
                     EKPNKTIVTILGINLLIIVIMCSMWFFGIILALIYSVVLFKILSDYSKKTIYEYNQLL
                     DVTKKISDGNLDVNMEKDLGFFNPIKDELGNIQTGFKKAVDEEVKSQKMKTELISNVS
                     HDLKTPLTSIITYIDLLKDESITDENRKLYIDTLDRKSQRLQHLIEDLFEVSKANSGD
                     VYLNIVNVDIVSLMKQTLLELDDKLADSSLIVKNNFSNEKIILPLDSQRTFRVFENLI
                     INISKYAMPNSRVYIDILETDNKVNIMLKNMSASEIDFSVDDIMERFVRGDKSRNTEG
                     SGLGLAIAKSFIELQGGKMNISVDGDLFKVTITFNKN"
     gene            complement(11943..12659)
                     /locus_tag="KRO40_002911"
     CDS             complement(11943..12659)
                     /locus_tag="KRO40_002911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093721.1"
                     /translation="MNSYNILVVEDEKEIADAIEIYLLNQGYNVFKGYNGLEGLKVIE
                     NQEIHLAIVDIMMPKMDGITLTMKLRENYNFPVIMLSAKSEEVDKIMGLNIGADDYVT
                     KPFKPLELLARVNSQLRRYTKYLNMVGNKEQKVESDDSVFAIGGLELNENTKEVSIDG
                     KYIKTTPIEFKILSLLMRNAGRVFSADEIYERVWNENAVNTDTVMVHVRNIREKIEID
                     PKNPKYLKVVWGVGYKIEKI"
BASE COUNT         4771 a         1789 c         1670 g         4581 t
ORIGIN      
        1 tgtgtaaggc aaatatatat ttctattgca aatttttgtt atttatgata atataaatat
       61 gtttttagtc tttaaatagt tatcatttta aggaggtgtg cgtagatggc aaaagtatgt
      121 agcgtatgtg gtaaaggtaa ggtttctgga aaccaagtat cacactcaaa taaacataat
      181 aaaagaacat ggtcagctaa cttaagaagc gtaagagcga ttatagatgg agctcctaag
      241 agagtaaaag tttgtactag atgtttacgt tctggtaaaa ttgaaagagc ttagtaacca
      301 cgtttaaaag cctacttccg taagtaggct ttttaattta atcattttta ctctttctca
      361 taaattttag gattatactt gaaatccatt ttggtaattt tattgttact actttcatca
      421 atactcaccc cacactttat agttaaaact attttaacaa aaaaataata atgctccaca
      481 tccaataagt attaatgcgg taagtgctga ccaaatccag ccaggaagca acattgacag
      541 aattacagcc attcctgttg ctagacaaag tattcctagc aataccttag acttgttatt
      601 tctcatggaa cacctccaca tagaacctgt atctataaat attttcatat tcaagtttat
      661 gcgacagttt tccattttag accaataaac acattatgta attttaattt ttcatactag
      721 aattattact gaactccgat atagattcta caatatccaa aattcctttt tttctactta
      781 acctttcagg tccactatat aaaacaactg gtataacttt aggaagttta aaatttttat
      841 cttctatttc ttcaaggctt tttttcataa taaaactttt ccaaatttgt tctctatacg
      901 atttcaatct tgggacaatt tcagtatcca tttctgtttg aaattctaac actatataat
      961 gtgatacttt gccgctttta gaaaatacct tataaattat atcaacttct tttcctttat
     1021 attcacatat aaaagatgtt tctaactcta tatttttaag agttaattct tttgctattg
     1081 agacacttgt aaaattttga atcaaactta aaaaactttc tttatctgaa tacattcttc
     1141 tgtactcttc tcgtttttca ttgcttcttt ttaaattcat acagttcctc ctagactata
     1201 gaccttctat tttttagtaa agatagtcta taaattttat tttttaattt tcactagtga
     1261 gtattgacag ttgtgtgtaa aatatccagt aaagatattt ttttatattt ttattaaaag
     1321 atataaattt ttatatttta atgtattgac atttacgttg cgtaaaagtg tatatttaat
     1381 ttataggagg tactacttat ggaatataca gttcaaaaat taagtaaact agctggtata
     1441 agtactagaa cacttagata ttatgatgaa ataggtcttc ttaagccact taaaataaat
     1501 tcttcaggtt atcgtatata tggtcaaaat gaagttaata aacttcaaca aatacttttt
     1561 tatagagaat taggaattaa cttagaaaat ataaaaaaca ttataaattc accaaacttc
     1621 gatagtttaa gtgcgttaaa agaacaccat aataaattac tagccaaaag aaagcaaatt
     1681 gatttactaa tagaaaatgt aactaaaact atagctctga aggagggaaa atacactatg
     1741 acagatatag aaaaatttga aggttttaaa gaaaagatga ttgatgaaaa tgaaaaaaat
     1801 tatggaactg aaattagaga gaaatatggt aaagatatta tagatacatc aaataaaaaa
     1861 cttaaaaata tgtctaagca agattatgaa aattggcaaa acctaaatat cgaaataatt
     1921 agtaaactta aaaaagcttt taaaactggt gatgcctcta gtgaactggc tcaggaagtt
     1981 gcaaaattac atcataaatg gttgtgttac acttggaaca catactctaa agaagctcat
     2041 tcctctctag cacagatgta tgtatatgat gaacgtttta catcatatta tgatagagaa
     2101 caacctggat tagctaagtt tttaagggat gctatagtaa tatatacaag agataaataa
     2161 tataaaataa taaaggtggt gtctcaaaat gaacttttta gttcatgaga cactcttttt
     2221 tgtatgaaat cagatatatt tttatcattt tatcaatgaa aaacaggttt ctctctctat
     2281 tttgagacag aatctttatt gtataataat tataatcaat acaaaataat aacaaattat
     2341 acaaaactta cttatactat ttatgctaaa aacaaaaaat attttattaa agtttttaaa
     2401 acttatgtaa tataaaaatc tatactatag acttgattat ggaaagaaaa ttatcaaaat
     2461 cattacaatt agatatacta tctctaatat cattgtcatg aattatcttt aaaaggatat
     2521 cataaatgga gtttattttt atataatcat ctttatttat agccaacatc atgattaatt
     2581 taacagtaga attttcactc caatatattg gttcattcaa tatggaaata caaatcttag
     2641 ttcttataga gcttaattcc ataggatgag gtatagctaa aaaatcatct atattggtag
     2701 aagataaact ttctctgtaa aatacagatt cagcaaatga tggaaataca atttcacttt
     2761 gagttaattt gttgcacatc aactttataa gctcatcttt atctttgatt ttaggattaa
     2821 caataaataa atttttatca aagaaattgt ccaaaagatt actataaata tgggaattat
     2881 tagtgattga cttagatata ttctctatat ctttttttaa tagttttaaa tccactaata
     2941 caataggaat actatcatga tttaaaggaa ttgtcgatat tattatatct acatctgaca
     3001 attcactagc taaaaattga ttaaatgata gacattgaag tatatttatt ttatcatgaa
     3061 aaactttgtt taattgaacc tctaataacc tacttgaacc ataccctgaa ccacatacta
     3121 atactacgtt tttacactta atattacttt gaaaaaatct ctctattcca gcacctatat
     3181 gcagggatac atatccaatt tcatcttctg ttaaagagta aatactattt ttaaaaactt
     3241 tttctatagc atttaaagtt atttcaaatg ctaaaggata attactcttt attgtattta
     3301 taaggggatt caccttattt aaattataag atttagaatt gagaattgat ttaaagtgca
     3361 gtactaaatc atcaaataat acactatcat ttctaaggtc aaaagtatat tgattgttga
     3421 ttacttctaa aatttcttca acatactcta taattttagt atctacccta ttggaaacgt
     3481 tatccaaaag agaactttta gttataaaat gattatatag ataaactctg tctgcctttg
     3541 aaataattat agtatattta ctctcaatat aattaaatat attttcaaca gttgtattcg
     3601 attgaaaatc tgttaaaaca acatctaaaa cattatctaa gcagtaacca tcaagtattc
     3661 tacttacagt aatagctaaa tggataataa agttttttag attaaaatct aggaaattga
     3721 tattaaattt attaatttca cttaacacta ccctttgaag ctctattaaa tctacattat
     3781 taaataattc tatttctcta tctgtaattc caattatata gttttcaaaa ttcctattta
     3841 tcatattatt agaaatacat cttcgaatat ctatttcctt accttcaact ttaactccat
     3901 aatatggctt agaaactaat attaaattat actttgacaa aataggcttt attcttttta
     3961 tgtcatttag tattgtaaat ttactcacat acaagctatt agctaaatct tctagtttta
     4021 tatatgtatt gttatagaga atatatttta aaatatattg atttctttct ataggagaat
     4081 ctggtatttc acttgaatcc ataatatcat cagatattaa tgctagatac tgttggtata
     4141 atgctaaatt aagaatatct atataatatc cttctccttt ttttatttta ataatagcac
     4201 catttttctc taaagttcca tttatagaag taatatcatt tcttatagtt ctctcactca
     4261 cttttaaatg attacttaaa gttttacaag taattttatc atcactttca tttaataatt
     4321 taaacaacgt gagcaatctc ttgtgcataa atatcccccc ttatagaatt tcttctaaat
     4381 tatactattt acactcatat aatacaatta ctctaataaa attgtattat aataatttat
     4441 ttccacttct atatggaaat tagttattat cataatataa atttccatgt cgaagtggaa
     4501 attagttata tttaatttaa ttaggataat gattacaata taaatataag ttaagacatt
     4561 atgaatggag tggaaaaata tatggtacta caagaaaaat atatatttat agataaagac
     4621 ttaaaaagca aagaagaagt attaaatttt attgcagata gtgcttatat actaggtatt
     4681 acaactaata aagaggctct tttaaaagac cttctaaaaa gagaaaatga atttccaaca
     4741 ggaataaaag atggatttgc gatacctcat acaaagagtg taaatgtaaa ggaagcttcc
     4801 atactctata ttaaaacaac taacgagtta gagtggaaaa ctttagatga tagtaaggtt
     4861 agatatgtat ttagtttgtt agccccacat aaaaatgaag gaaatataca tttgaaaact
     4921 ctatctaaat tagccacatg tttaatggag gatgatttta caagtgaagt taaaaatgct
     4981 agtgatgcaa gtcatttagt aaaatatata actaataaaa tgaaggagga ataattatga
     5041 aaatagtagc tataacatca tgtatagcag gattagcaca cacacctatg gcagcaaaag
     5101 ctttagaaca agctgcatca aaaatgggtc atgaaatcaa agtagaacaa caaggtgcta
     5161 tgggacgagt aaatactata acaaaagaag aagcacaaga tgcggacttt atacttatag
     5221 catctgacca aactatatct ggaatggaaa gatttgatgg taaaaaagtg ataaaagtca
     5281 aaataggtat agcgttaaaa aaaccagaag ctgtcttaac aaagtgtata gaagctattt
     5341 cttaataaaa aaatctcact ctaatataga atgagaaaaa tcaaaaatta aaaaattgtc
     5401 taatgtaatt ataacatatt atcaaaaaat ataacaaact tatataggag gattaaaaat
     5461 gagtaaaaaa aataaatctc ttttaagtga acttaaggga cacttaatga caggtatctc
     5521 atatatgttg ccacttgtaa taggctcatc tttagttgta gctatcccaa agcttacagc
     5581 tttagcagtg ggtataacaa gtttagatgc ttataaaaat gtatctggtt tttatcatat
     5641 tctttactta atggaacaag ttggttggac tggcataggt ctattaaata cggtattagc
     5701 aggatttata gcattttcaa taggtgagaa accagctatg ggtgcaggtt ttattggtgg
     5761 gctcatagca agtaatacta atgcaggatt cttaggagca gtaatagcag gtttctttgc
     5821 tgggtatgtt tgtaagtttt taaagaaaaa aattaaaata tctgggtcag catcaggaat
     5881 gatgccactt ataataatgc cacttataac agttggatta actggttttt taatgagtgt
     5941 tgtattagca ggacctttag gaaacataaa tacttcatta aatgcttggg tagctgaaat
     6001 gtgtcaaaat ggaacaaatt cggtggtatt ggctttaatt ttaggcgcaa tgataggatt
     6061 cgatttaggt ggaccagtaa ataaagcagc ttggatggca ggaaatgcat tattgttaga
     6121 gggaatctat ctaccagcga tattggtaaa ctgcgcaata gttatacctc cactaggata
     6181 tggtttagct acattcataa gaaaatcaaa attttccaat gcattagctg aaacaggaaa
     6241 aggcaatata gttatgggta taattggaat aacagaaggt gcaattcctt tcactttaac
     6301 aaatccatta aaattagttc ctgttaatat gataggatgc gctttgggtg taggattatc
     6361 agctttgtta ggtgtacatg ctataatgcc tccagttggt ggattatatg gatttatatc
     6421 aataggttct ggatgggctt acttagtagg tgcaatattt ggagctttag taatagcaat
     6481 attatcaaca actttagtag acttcaatga agatgaaact acggaaaata cagaatttga
     6541 tgaaatagag ttagatataa tgtaaattaa aaacttaatt ttagataatt gagaattgag
     6601 tgtactctca attctcaatt aaattttggg aggattttta tgaaaaagac aaaagtacat
     6661 gtagttccac acagtcattg ggatagagaa tggtatttta caacatcaag gtcaaaaata
     6721 tatttaatga aagattttca agatatatta gacatattgg aagaaaaaga agactttaaa
     6781 tactttacta tggatgcaca agcttctctc ttagatgatt atttaaaatg gagacctcag
     6841 gataaatata gaataagaga tttagttcaa agaagaagat tagttattgg accttggtat
     6901 actcaaacag accaattggt tatatcagga gaatctataa ttagaaacct ttactatgga
     6961 atagatagat gcaatgaatt tggtgaacct atgagggttg gatatgtacc agattctttt
     7021 gggcaatcag ctcaaatgcc acaaatatac agaggttttg gaatagatag ttcattattt
     7081 tggcgtggag tttctgatga tatggtagat acaacagagt ttatatggaa aggttctgat
     7141 ggttcaaaag tattagcagt tcaaatacca tttggttatt actatggagg taatatacca
     7201 gaagatgatt cagatttaaa agaatattta aaagatataa tcgtaaaact taaggttaaa
     7261 gcttctacta ataacgtata ttttccaaat ggatttgacc aagcaccaat aagaaaaaac
     7321 cttcctgata tattaaaaaa agctaatgaa atagataatg aaaatgaata cgaaataagt
     7381 gatatagaaa actatataga ttcagtaaga aatgaaagaa atgaatttac agagcttaaa
     7441 ggtgaatttt taaatgctaa acatatgaga atacacaaat ccatattctc ctcaaggtca
     7501 gaccttaaaa taatgaataa caaattagaa aattatatta caaatgtact tgaaccgtta
     7561 ttaacattaa gttattcact tggaaatgaa taccctcacc tagttataaa agatatatgg
     7621 aaacttatgt ttgaaaatgc agctcatgac agcataggtt cttgtaatag tgacacaaca
     7681 aatgaggatg tatacacaag atacaaacaa gccagagatt tgagtataaa tttattagat
     7741 ttgcatatga gacttataag tactcaaatc aaaaataata atgaagaaat aacattaaca
     7801 gtattcaatg gattcccaga agtcagaaat gaagttgtag aatttgatac ttatattcca
     7861 ggtcaagatt ttgtgataaa gaataaaaat ggaaaaattc ttaattatat aataaaagaa
     7921 aaagaagata ttacaaatta tatattaact caaacaataa gattaaaccc aagtaaaaaa
     7981 atatatatac ccaaaactgt atatagagca aaaattgcac tttcagtaaa agatatacca
     8041 ccaatgggat atactcaact agtttttgaa ttggatacta aaaataaatg tgaaatagaa
     8101 acaagtaatt gcaaggaaat agaaaacaaa tactacaaaa taacagccaa taaaaatggt
     8161 tcattagaaa tattagataa agaatctaat aagacttata aaaaccaagc tgtaattgaa
     8221 gacaatggag atgatggaga ttcatacaac tattctcctc caagaaaaga tatttatgtt
     8281 tcatctttag attctgtatc ttcagtagaa gtgctaaaat caaacattca agaagaaatg
     8341 atacttaaat attcattgac cataccagct tcactggaag aaagggctat aggtaaagtt
     8401 tctgtgaaaa tgccagtaac aatgaaaatc accttagaac ctaaagaaca aataattaag
     8461 tttaatgtta atataaaaaa taaccaagca ctatctcata gagtaagagt tttatttaat
     8521 acagaaatag catctaagtt ttctatagca gatcaacaat ttggaataat acaaagacca
     8581 acagtattag aaaaagacct tgcattgtgg aaaagagaca attactcatg gcaagaaaaa
     8641 cctataacta tcgaaccaat gcaaagtttt gttactttag aggatggaca aagaggaata
     8701 gcattaataa ctggttgtgt aagagaatat caaatagttg gtgataattt agatacaata
     8761 gcattaacac tattcaggtc atttggatat atgggaagag aaaatttact ttatagacca
     8821 ggaagagctt ctggagaaaa aataatagca acaccagatg cacaattact taaagagtta
     8881 aactttgact ttggtcttta catatataac aataaatttg atgaagcaaa tgtagctaat
     8941 acagctaaga gattcttaac acctatacaa atatatgaat atgctgattt tttaaatggt
     9001 agacttatat ttgcattcaa tgacgaaaaa caaatatatg aaaatgaatt tagtttgatg
     9061 aatgtaaata attcaaattt cacagtaagt gcaataaaga aagaagaaaa aggagatgga
     9121 attgtagtta gaatcttcaa tggtatgaaa aatgaggatg ctaagggaag tcttaacatc
     9181 aataaaaatg tcaatgatgc ttatagtgca atgctcgacg aaatctatga taatactagc
     9241 aagcttaaag taaatactaa aactgtagag gtaaattctt tatcacattg taaagtacaa
     9301 acaatagtaa ttaaataata taaaatagct tatacaagat ttcaaaataa attgctagta
     9361 ccatgttaat agtaaagcca gatattatgc tatttataag ctctgtaaca ctaaataaca
     9421 ttttgtaaaa taaaaaggtg aaccttgtat attaggattc acctttttta aataaatcaa
     9481 cattctgttt taaaataaca tttataagct gttttgaaat aatgcttaca aattatttta
     9541 aaacaatacc tataaatttt tatttaaaga atacacataa atatttccag actcttttat
     9601 cctatagact ttataattat taaagaagtc taatctaatt tttgttaaaa gtaattgtaa
     9661 ctttaaataa atcaccatcc acacttatat tcatcttacc accctgtaat tctataaaac
     9721 tttttgctat cgctaaacca agaccagaac cttctgtgtt acgtgattta tctcctctta
     9781 caaatctctc cattatatca tctacactaa aatcaatctc agatgcagac atatttttaa
     9841 gcataatatt tactttatta tctgtttcta aaatatcaat atacactctt gaatttggca
     9901 ttgcatattt gcttatattt attataagat tttcaaatac tctaaatgta cgctgactat
     9961 ctaatggtaa tattattttt tcattagaaa agttattctt tactattaga gatgaatctg
    10021 caagtttgtc atctaattct aaaagtgtct gcttcattag agatacaata tccacattta
    10081 ctatattcaa ataaacatct ccactatttg ccttgcttac ttcaaacaaa tcttctatta
    10141 gatgttgcaa tctttgtgac tttctgtcta atgtatcaat atacaactta cgattttcat
    10201 ctgttatact ttcatctttt aataaatcta tataagtgat tatagatgtt agaggtgttt
    10261 ttaagtcatg tgatacattt gatataagct ctgttttcat cttttgactc ttaacctctt
    10321 cgtcaacagc ttttttaaat ccagtttgaa tatttcctaa ttcgtctttt ataggattaa
    10381 aaaatcctaa atctttttcc atatttacat ctaagtttcc atctgaaatt ttctttgtaa
    10441 catctaaaag ttgattatat tcatatattg tctttttaga gtaatctgac agtattttaa
    10501 ataatactac tgaatatatt aatgcgagta ttattccaaa gaaccacata ctacacatta
    10561 taactataat caataaattt attcccaaaa ttgtaactat agttttattt ggcttttctt
    10621 ttagatttat tgttctaatt tgattaataa ctgtttttcc tgcttttttt agccatacaa
    10681 aaaacattcc tgtcacagta tgttttgtaa aatactctct tattccaaca tttaaaatat
    10741 gttttaaaag tattataaat acaaatatta ttgagaatat tacaaaccaa taagttaaat
    10801 tcattaaact taccaatata ctagccattt tagcacttat gtcattgttt ataaggtact
    10861 ctacataatt cccactcaag gtattactta ttataacagt aggatataaa tctacaagcc
    10921 cctgtataat atcaagagca ataaagagta tctctaacgg tattcttgat aatgtatcaa
    10981 atcctagcaa ctctttagat tttctatatg ggaatgctaa agctacaata acaactatag
    11041 ctaatataat ttttaaaatc attccagaaa tcttataata agaattattt tctacattgc
    11101 ttatatatga aattatacca tcatcaaaat aagtatttcc ataaccatac tctacactat
    11161 cacctttact tattacttta ggtacagcat atactaatgt tatatttttt attggagata
    11221 acttatatga aattgaattt cctcctaaac ttgtatccat taaatcttct cttgctttag
    11281 ataacaacat ttgattaata attttttgat ttactccata agaatccaca atatttactt
    11341 ttccatcttt atcaaaattc attacaacgt agaatctata gttttctttt atatctgtaa
    11401 tctgcttttg tctttcctca tcattcattt ctgtattttt tgactgattt tcatcagaat
    11461 tttcttttga agcatcattt tttgttgtat caagtactcc taattcttta ttatcattaa
    11521 aaaattcaaa attgctttct ttatcaacta aatagtactt taaattcttt cctgacgctt
    11581 taatgaaatg ctcccaattt tcaaagtttt cattaaaatc tgcattaata ctatcatctg
    11641 tatagtaagt ttctgaacca tcataagtat ctttttcttt acttacattt tttatatagt
    11701 tcatagtttc ttcattgata aatagttttg atggttgtat catcttacct tcttgttctt
    11761 ccttcatatt atgatataaa acataacttc ctttatatat actatctaca aagctttcct
    11821 gttcaaatgg attctctgct ccacctttag cacttgcttg tatagtagaa tattgactaa
    11881 tcatacctaa tgatgctgat aacataagta taaaaactat aatagtaact atatatttat
    11941 ctttaaattt tttcaatttt gtatccaaca ccccacacca cctttaaata tttaggattt
    12001 tttgggtcaa tttctatctt ttcccttata ttcctcacat gtaccataac tgtatctgta
    12061 tttacagcat tctcattcca aactctttca tatatttcat cagcagaaaa aactcttcct
    12121 gcatttctca taagtaaact tagtatttta aattctatag gagttgtttt tatatacttt
    12181 ccatcaatac taacttcttt tgtattttca tttaattcta atccgcctat tgcaaacaca
    12241 ctatcgtcac tttctacctt ttgctcttta tttccaacca tgtttagata cttagtgtac
    12301 cttctaagtt gtgaattaac tctagccaat agttctaatg gcttaaaagg ttttgttaca
    12361 taatcgtctg ctcctatatt aagccccatt attttgtcaa cttcctctga ttttgcagat
    12421 agcattatta ctggaaaatt atagttttct ctaagcttca ttgtaagtgt tataccatcc
    12481 attttaggca tcattatatc aactatagct aaatgtattt cttggttttc tataacctta
    12541 agaccttcta atccattgta tcccttaaaa acattatatc cttgatttaa tagatatatt
    12601 tctatagcat ctgctatctc cttttcatct tctaccacca aaatattata tgaattcatt
    12661 ctaatctcct ttatattaat ttataaattt tctttacata tatgattata caatatgata
    12721 gaagtttttc catttatata tatatttata tcttttgttc tggttatttg tatttaatgt
    12781 ccatcttaga aacctccttc tagtttaaat t
//
LOCUS       DAEQCW010000103        12716 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.104, whole genome shotgun sequence.
ACCESSION   DAEQCW010000103 DAEQCW010000000
VERSION     DAEQCW010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12716)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12716)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12716
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.104"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..392)
                     /locus_tag="KRO40_002912"
     CDS             complement(<1..392)
                     /locus_tag="KRO40_002912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093722.1"
                     /translation="MSKVAKATFYLMIVTIISKILGMGRELVLSSIYGTGLYTESYLT
                     AMNIPNIIFAAIGTAIVTTFIPMYQDISSKQGEKQALKFLNNVLNIIVGICIVVAILG
                     VIFSKQLVSIFAIGFEGERFLLTVKFTK"
     gene            complement(866..1750)
                     /locus_tag="KRO40_002913"
     CDS             complement(866..1750)
                     /locus_tag="KRO40_002913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2093723.1"
                     /translation="MDTKKENNYENYICVGSSNVSNAMKMYLKEIEEYKMLSAGEEVE
                     LAKEIINSSSVAKEKFINSNYRLVVSIAKRYKRDSIDMLDLIQAGNIGLIKAVEKYDY
                     KKGYKFSTYATWWIKQSITRYIDDCENTIRIPIHLHQRINFVKKKKQELLNVLLREPT
                     IDEIADACGLEVDKVLELLRRDKNVVSLDTPLKEDEDSSLVEFIPSDADFKDVVIHEV
                     EQHNLKEKIEELLTGLGEQEQQVLRMRFGIDDDDPKTLEQIGKVFGVTRERIRQIEAK
                     AIRKLRHPSKLKQLKHFY"
     gene            complement(2041..2517)
                     /locus_tag="KRO40_002914"
     CDS             complement(2041..2517)
                     /locus_tag="KRO40_002914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction enzyme HsdR N-terminal
                     domain-containing protein"
                     /protein_id="HBH2093724.1"
                     /translation="MSKELVKDRVIKYLIEDLLVPQDMIDTNVELAEFEEGAEGILDI
                     VVNVKDEEDYYAPVMIVQCLDEDVELEGEVLQKQIEFLEEVDNITMSGRLVLTNGDAM
                     MYADWRGEEYDTEAALPTYDIMVKEFHEMEQQVKDLEEHHHHDENCGCGCNHHHEN"
     gene            2783..3958
                     /locus_tag="KRO40_002915"
     CDS             2783..3958
                     /locus_tag="KRO40_002915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HBH2093725.1"
                     /translation="MKFKKQISSIVVSTMLVLGSMNLSYADGTNVVTLGANLSESQKQ
                     QMLNYFGVKKDQVLVLDVTNAEERQYLQGVATEGQLGKVTISCSYVEPTKKGNGINVK
                     TANLTWVTSSMIASTLTTAGLEDANVIAAAPYPVSGTGALTGIMKAFEDASGKKLDET
                     KKEIASEELVVTGDLGDDIGQEKATGVMNDIKTEIVKNGTKDTNQIANTINNVVNNYN
                     ITITPEQKEQIKGVMKKIADQNYDYNSMKNTLDNVSDNVNEQLKKLGESVKGSGILDT
                     IGGWFSGIGDWFSGLFSGGDKKDLGILNNTNDESLGSDAVINSTEGVQINPQNNTNSN
                     NDSDTNSSKNDTSSNNENNDSSQTNENNTTNNSENQSNNNDSVGFFEKIKNWLSGLF"
     gene            complement(4039..4842)
                     /gene="proC"
                     /locus_tag="KRO40_002916"
     CDS             complement(4039..4842)
                     /gene="proC"
                     /locus_tag="KRO40_002916"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBH2093726.1"
                     /translation="MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRI
                     DANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILEEIKDFIDDNKIIVTIAAGKSIK
                     DIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
                     EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPGGTTIEAVKVLEEEGFRASVIKAICACIEKSKKMSE"
     gene            complement(4882..5466)
                     /locus_tag="KRO40_002917"
     CDS             complement(4882..5466)
                     /locus_tag="KRO40_002917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093727.1"
                     /translation="MNKDIGAKIKQLRTQKQMTLKDMSEKTNLSIGFLSQLERGLTSV
                     ATDSLGKIASVLDVELTYFFMKPKEHKRAVLRSYEKEVFDVENSTFIHYHLSSSLKEK
                     TMLPRLIEILPSKSSEEICCYVHEGEEFVYVLEGTLTVFLGDEQIEMYPGDTIHYNSE
                     KNNHNWVNYTNKVVKILVVSIPNPFEKSDAVKEA"
     gene            complement(6351..6959)
                     /locus_tag="KRO40_002918"
     CDS             complement(6351..6959)
                     /locus_tag="KRO40_002918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="HBH2093728.1"
                     /translation="MEKDFFRKNGIDLAKSILGKYLIRKYENKVIVTKIIETEAYMGV
                     NDKGAHVYGNKKTDRTKPLYLDGGHIYVYLIYGMYNCLNLSANIENVPECVLIRGVEP
                     ITSLDEISMNRYNKAYTELSKYQVKNITNGPGKLCKALKIDRSLNSKSIMGEELYISD
                     FYYDDKGKKVFSKDELDIKTSKRINIDYAEEAKDFLWRFYIE"
     gene            complement(7068..9806)
                     /locus_tag="KRO40_002919"
     CDS             complement(7068..9806)
                     /locus_tag="KRO40_002919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing sensor histidine kinase"
                     /protein_id="HBH2093729.1"
                     /translation="MESKGTLSKNKVYILANGLFLVIALLNINLYTVSINMYRIILLW
                     IFGYSIVYISSFKTDEFINILKVGCLVLVFVSILGVVNLKIQKFQIVLLNLSIINMST
                     FIYLTISKVKKLRISPILIFYSAFVILDYFIRNIFSDINWNMIIILINICISMFNLLY
                     LLNKLDSNIEHYKLIKDLTYFVFFTTIICFVAISKINIVDSDRLIGVIYLLLCNHTYY
                     VYVYSLNNRVVYPYYELDSINKKLSKKSEQLGKINLAIEKDMIIQRTLKNYIDQRKEL
                     LRQALDTIPNVWIVTDYDFNISYTNNKFKDEFSKDMNNYYKILTFIKEDEKVAEKLKK
                     FDNDISIIDKLVELNDKIYLLSLSNNKDESNYLISLNDITNEIKIDEEIRNINKDYEN
                     IILNIPSPILVRSAEGGIKKNKVISINKKYEKSFKCVSSDLVDMTLEQYFETFNIDFF
                     DNREFKRLNLTQEKKAEIVSYNDTANCIVNFVMSDSEGEEHVEEVRVGDYWSDNKLFK
                     LLTFRDITKEINILRTVNEQKIIYEKLLDVIPEAIFLEDLSTSRVLYTNRAFRELFGI
                     SSDVLGVTTQKYRNILVKKYINNLNIGEREKSIHIVNENNHIKEVKMISRTLYFGQKR
                     SRVRIIKDLSVQRESERLKKALIKQRQYDQMKMEFYANISHELKTPLNNIYSSVQLIE
                     NLYKKGKIIDFQDILKEHIKITKQNMFRLLRLIDNIINISQVKSDIYKIKAVNFDIID
                     ITERIVTSISSYAKSKGIDLIFDTDEETVMVGLDPESIERIILNILSNAIKFTLEGGE
                     ILVGIYKKDETVEIIIKDTGVGIDKEKLKDIFNRFKQIENSGISNEFGSGIGLCLTKS
                     LIEIQNGKIYIDSKVGEGTNVKVIFPIKEVVEEVYDNSNYNDNIEKFEIEFFDIYK"
     gene            complement(9954..10745)
                     /locus_tag="KRO40_002920"
     CDS             complement(9954..10745)
                     /locus_tag="KRO40_002920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2093730.1"
                     /translation="MKLKKLLSVALVSAIAISAVGCSNKEDKKILVGASSNPHAKILE
                     VAKPLLKEKGYDLEVKIFDDYVLPNTALDEGSLDANFFQHIPFLEETVKEKGYKLTYT
                     SKVHIEPMGFYSEKVKSLDELKDGAVIAVPNDATNGARALKLLAKNKLIEVKDGELIT
                     KKDITKNPKNIVIKEMNAEQLPTVLKDVDGAVINSNYALTANLNPTKDAIVIESSDSP
                     YVNIIACRENNKDSDKIKALSEAMNSKEVKKFIQDEYKGSIVPAF"
     gene            complement(10781..11437)
                     /locus_tag="KRO40_002921"
     CDS             complement(10781..11437)
                     /locus_tag="KRO40_002921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093731.1"
                     /translation="MNSLIDFLTTLFPNALLQTLYMVIVPTIVATILGFILAIILVVT
                     KPDGLKPNSTINSALGFIVNIFRSFPFMILIVAMIPITRLIVGTSIGETAAIVPITIG
                     AAPFIARIIESSLNEVDKGLIEAAKSFGATKRQIVFKVMIKEAMPSIVSGITLSIISI
                     LGYTAMAGAVGAGGLGNIALIYGYQRFDTAVMVYTVIALIILVQIIQGVGNLAYKKLK
                     "
     gene            complement(11430..12395)
                     /locus_tag="KRO40_002922"
     CDS             complement(11430..12395)
                     /locus_tag="KRO40_002922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HBH2093732.1"
                     /translation="MISIKNVNKYYGKIQVLKDVSIEIESGEIFGIIGHSGAGKSTLL
                     RCINGLEEYQEGSVLVSDKEVKSLNEKQMRDLRKELGMIFQHFSLLERKTVFDNVALP
                     LECFGYSKAEIKKRVLELLEVVGISEKKNDKPRNLSGGQKQRVAIARALALNPQVLLC
                     DEATSALDPNTTKSILSLLEDINKKLGITIIVVTHQMEVIKQICGRVAIMENGEVLEV
                     GDTEEIFLRNTKGLRKLIGEESIILPKGTNIKILFPKDISNEAIITTMARELNIDVSI
                     IFGKLEQFKDDILGSLIINISDKSGEQVKQYLTSKGIRWEEMINE"
     regulatory      complement(12501..12607)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
BASE COUNT         4149 a         2127 c         1263 g         5177 t
ORIGIN      
        1 attttagtaa attttacggt aagtaaaaac ctctctcctt caaatcctat agcaaatata
       61 cttacaagtt gctttgagaa aataactcct aatatagcta caactatgca tataccaact
      121 attatattta aaacattgtt taaaaacttt agtgcttgct tttcaccttg tttactactt
      181 atatcttgat acattggaat aaaagtagta actatagcag tacctattgc tgcaaatata
      241 atatttggta tattcatagc tgttaaataa ctctctgtat ataagcctgt accataaatt
      301 gatgataata ctaattctct acccattcca agaatcttag agattatagt aactatcatc
      361 aaataaaaag ttgctttagc taccttgctc attttatcac tccacttcta acatacctct
      421 ttttaatcaa gtaaaattta gctcattaga tataattcta tcaactaatt tgccttgctt
      481 agccctatca aaatataatt aacacctatt tcttaatata tcacaaacta cattattctt
      541 catatttttt tatttctcca ataagtttta catttttcct atataaattg tatagcttca
      601 attatattca aagaaatgga gttgctaccc gataacttta aaagtaaaaa acagatttta
      661 ttatcttttt aaactatatt ctaacatatt ttgtccatat tgagaaattt tactaaacta
      721 ttatgtactt tattaaataa ataaaataac agcacaccta taaaatacaa gtgtgctgtt
      781 cataaacaga ttttataaaa aaataattcc taagtagaga ttaacatgct ttctcatact
      841 ctcatatata atgtgtctaa aaatattaat aaaaatgctt taattgtttt aacttacttg
      901 gatgtcttaa ttttcttatt gctttagctt ctatctgtct tattcgttct ctggtaactc
      961 caaatacctt tccaatctgt tctagtgttt tagggtcatc atcatcaatt ccaaatctca
     1021 ttcttaaaac ttgctgttct tgctctccaa gacctgtaag tagttcttct atcttttctt
     1081 ttaaattatg ctgttcaact tcgtgtatta caacatcttt aaaatcagca tctgatggta
     1141 taaattcaac taaactacta tcctcatctt cttttaatgg agtatccaaa gatacaacat
     1201 ttttatctct tcttaataat tccaacactt tgtcaacttc taagccacat gcatctgcaa
     1261 tctcatctat agttggctct cttaataata catttaaaag ttcttgtttc tttttcttta
     1321 caaaatttat tctctgatga agatgtatag gtatcctaat agtattttcg caatcgtcga
     1381 tatatcttgt tatactttgt tttatccacc aagttgcata agtgctaaat ttgtatcctt
     1441 ttttataatc gtacttttct acagctttta taagtcctat atttcctgct tgaattaaat
     1501 ccaacatatc aatactatct cttttatatc tctttgctat gctcactacc aacctataat
     1561 ttgaatttat aaatttttct tttgctactg aagatgagtt gattatttcc ttagccagct
     1621 ctacctcttc tcctgctgac aacattttgt attcctctat ttcctttaaa tacattttca
     1681 tcgcattcga tacatttgat gaacccacac aaatataatt ttcataatta ttttcttttt
     1741 tagtatccat aatcaaaccc cttctattca tagaatttgc taaaacaaaa ataaataatt
     1801 taaacctaca taatctacaa ttacataata tcccattctt taaatgaatt gttttgtata
     1861 ttatgtatac aaatttataa aaactatacc tataatatta ttctacttct aacagcaata
     1921 tcctccttat atatataatt tattttatta tatgttgtta tattcttagt tttttgaatg
     1981 atatatgtct aaaaaaagac tgtttactaa acagtctttt tttatatata tgctcaatat
     2041 ttaattttca tgatgatgat tacatccaca tccacaattt tcatcatggt gatgatgttc
     2101 ttctaaatct tttacctgtt gttccatttc atgaaactct tttaccatta tatcataagt
     2161 tggaagagct gcctcagtat cgtattcttc ccctctccaa tcagcgtaca tcatagcatc
     2221 tccattagtt aaaaccaatc tacctgacat agttatatta tccacttctt ctaaaaattc
     2281 tatttgtttt tgtaaaactt ctccttctaa ctccacatct tcatctaaac attgcactat
     2341 cattacaggt gcataataat cttcttcatc tttaacattt acaacaatat ctaaaattcc
     2401 ttctgcacct tcttcaaatt ctgccaactc aacatttgta tcaatcatat cttgaggtac
     2461 taataaatct tctattaaat attttattac tctatctttt actaattctt ttgacattta
     2521 tttttctcct tccgattcta taacattatc ataatcattt ctatattata gtatactaca
     2581 ttaattgttt tttcaatctc ttacaaaaat tattttttat tatcttcctt atattccctt
     2641 ttttattaca aagttgtaat cgcattgatt taaaaaatag tttatattta gtataataga
     2701 aatgtagcac atatttttat tcaatatatt aataaaaaaa tatattgaaa atgtaatgta
     2761 tgttaaatct aggaggaata ttatgaagtt taaaaaacaa attagttcta ttgttgtgtc
     2821 tactatgctt gtacttggga gtatgaacct ttcttatgca gacggtacaa atgtagttac
     2881 acttggagct aacttatcag agtctcaaaa gcagcaaatg cttaattact ttggagtaaa
     2941 aaaagaccaa gtcttagttt tagatgtaac aaatgcagaa gaaagacagt atttacaagg
     3001 tgttgcaaca gagggtcaac ttggaaaagt tactatctct tgctcatacg ttgaacctac
     3061 taaaaaagga aatggaatta atgttaaaac agcaaactta acttgggtaa ctagttcaat
     3121 gattgcttca acccttacaa cagctggtct tgaagatgca aatgttattg ctgctgctcc
     3181 atatcctgta agtggtactg gagcattgac aggaatcatg aaagcatttg aggatgcttc
     3241 aggaaagaaa cttgatgaaa ctaagaaaga aattgcttct gaagaattgg tagttacagg
     3301 tgacttagga gatgatatag ggcaagaaaa agcaacaggt gtaatgaatg atataaaaac
     3361 agaaattgta aagaatggta caaaagatac caatcaaata gcaaatacaa taaataatgt
     3421 tgtaaataat tacaatatta ctattacacc agaacaaaaa gaacaaatta aaggtgtaat
     3481 gaaaaaaata gctgaccaaa attacgatta caatagcatg aaaaatacac tagataatgt
     3541 atcagataat gtaaatgaac aattaaagaa attaggtgaa agtgttaagg gttctggtat
     3601 actagatact attggtggat ggtttagtgg aataggagac tggttctctg gtttattctc
     3661 aggcggagat aaaaaagatt tgggaatctt aaataatact aatgatgagt ctcttggctc
     3721 tgatgctgta ataaattcta cagaaggtgt tcaaataaat ccacaaaata atactaattc
     3781 taacaatgat agtgatacaa atagctcaaa aaatgatact tcaagtaata atgaaaataa
     3841 cgatagttct caaacaaatg aaaacaacac aacaaataat tcagaaaatc aatcaaataa
     3901 taatgactca gttggtttct ttgaaaaaat aaaaaattgg ctttcaggct tattttagaa
     3961 attaaacaaa taaaaagaat tgcctaaaat ggaaattttc tataaaaggc aattctcttt
     4021 atttacaata aatttttatt actcactcat ttttttagat ttttctatac atgcacatat
     4081 tgcttttatc acagaagctc taaaaccttc ttcttcaagt actttaactg cttctatagt
     4141 agttccacca ggtgaacata ccatatcttt taattcacca ggatgttttc ctgtctcaag
     4201 taccattttt gcagaaccca taacagcctg tgatgcaaac ttatatgctt gtggtcttgg
     4261 cattcctgca attactgctg catctgctat agcttctata aataaaaata catatgctgg
     4321 tgcagaacca cttgcaccaa ttacagcttc tataagatac tctggtacta cctcagtatt
     4381 tccaaaagaa ttaaatactt ctgtaactgc ttctaagtct tctttgttta tatttttatt
     4441 tatcgaaaga gaagacatgg cttcatttac aagagctgga gtatttggca tagttctaac
     4501 tattttttta tcttctccta taatagactc tatatctttt atagattttc ctgctgctat
     4561 tgtaactata attttattgt catctataaa gtcttttatc tcttccaaaa tatcatcata
     4621 tatatctggt ttaacagcta caattactat atcagaggtt ctagttactt ccttcgagtc
     4681 ttttgtagta tttattccaa aatttgcatc tattctatcg agagttcctt gactatatgc
     4741 tgatgctata accatattag gttcaactaa ttttgaattt actattcccc ctatcatagc
     4801 gcttgccata tttcctgcac ctatgaatcc aatttttttc actttagtac ctccttattg
     4861 actaatagta atcgttaaaa tttaagcttc tttaactgca tcagattttt caaatggatt
     4921 tggtatactt actaccaaaa ttttcactac cttattagta tagttgaccc aattatgatt
     4981 gttcttttca ctattatagt gtattgtgtc tcctggatac atttctattt gttcatctcc
     5041 caaaaacact gtaagagtac cctctaatac atacacaaat tcctcacctt catgtacgta
     5101 acaacaaatt tcctcactac tcttacttgg aagaatttca attaatcttg gtagcattgt
     5161 tttttccttt aaactagatg ataaatgata atgtataaat gttgagtttt ctacatcaaa
     5221 tacttctttt tcataacttc ttaatacagc tcttttatgc tcttttggct tcataaaaaa
     5281 gtaagttaat tctacatcta gtacacttgc tatttttcct aaggaatctg ttgccacact
     5341 tgttaatcct ctttcaagtt gtgataaaaa accaattgac aagtttgttt tttcactcat
     5401 atccttcagc gtcatttgct tttgagttct gagttgcttt atttttgctc ctatgtcctt
     5461 attcaaaacc atcaccccta aataatttta attttttcat aatataaata caaaaatata
     5521 aatataggta ctgaacccat ctttatttca tttaaaaaaa tttttataag tattactata
     5581 atttatcaat ctttttttgt ctacattttt acgattattt acgatttatt tttcacatat
     5641 gtatatttaa tcttgccaac taaagataca ttttttataa gcatttactc tttatataat
     5701 aaaacttaag ttgttcatgt agtcttcttc tggtttaatt attaaaattt caaattatat
     5761 tattatttct acacattatt acatccttta gtacaattat aacataattt tacaatttaa
     5821 tgatatctat tcaatgtctt tttttactct acaacatatt ttattttaga gtttaatact
     5881 atatatattt tttatataca gccttgtcat tttttagatt gtcaagagtt attgaagtat
     5941 tttatgtaga tttagatttt atttcctaat ttctcattta acaagaattg cttatgataa
     6001 aaaataatat catctcaata agattcttgt aaatatatct atattctaaa tataatttct
     6061 ttttttgtca aaatttcttc attctttaat aattaattta ttacttataa aataaactaa
     6121 ttatctatac aaattttata atttttaata aaatacacaa aaaaattaat ttttatagct
     6181 catttcgcca aaatatatct ttctttatat cattaaaata attataaatt tattaaatat
     6241 gtttgtaatt ctataaagtt atttttatca aactaaaaat tctataaaaa aataagatac
     6301 atacctataa aataccttcc tatagataca tatcttacct atataaaaac ttattctata
     6361 taaaaacgcc ataaaaaatc ttttgcttct tctgcataat ctatatttat acgtttacta
     6421 gtttttatat ctaactcatc tttactaaat actttttttc ctttatcatc ataataaaaa
     6481 tcacttatat ataattcttc acccattata ctcttactat ttagacttct atctattttt
     6541 aaagctttgc aaagttttcc tggtccgtta gtaatatttt ttacttgata tttactcaac
     6601 tcagtgtaag ctttgttgta tctattcata gatatctcat ctaaagaagt tataggctct
     6661 acccctctta ttaatacaca ctctggcaca ttttctatat ttgcagataa attcaagcaa
     6721 ttatacatac cataaattaa ataaacatat atatgtccac catctaaata taatggctta
     6781 gttctatctg tctttttatt gccatataca tgtgctcctt tatcatttac acccatgtat
     6841 gcttctgtct ctatgatttt ggtaacaatt actttatttt catatttcct tattagatat
     6901 ttacctaata ttgatttggc taaatcaatt ccattttttc taaaaaaatc cttttccaaa
     6961 atttcacctc ataaaattta tttaaaacgc atcaaataca actaaagtaa taaataaaat
     7021 taactcttat taatgtgata tatataaaca ataaatttag acatttatta tttatatata
     7081 tcaaaaaatt ctatctcaaa cttttcaata ttatcattgt aatttgaatt atcatatact
     7141 tcttcaacaa cctctttaat tgggaatata acttttacat tagttccttc tcctacctta
     7201 ctatctatgt aaatcttccc attttgaatt tcaatcaatg attttgtaag gcataaacct
     7261 ataccacttc caaattcatt tgatatacca ctgttttcaa tttgtttaaa tcgattaaat
     7321 atatccttta atttttcttt gtctatgccc actccagtat cttttataat tatctctact
     7381 gtttcgtctt ttttatatat acctacaagg atttctcctc cttctaaagt aaattttata
     7441 gcatttgata atatatttag tattattctt tctatcgatt ctgggtcaag ccctaccata
     7501 acagtttctt catctgtatc aaaaattaaa tctattcctt tagacttagc ataactacta
     7561 atagatgtaa ctattctttc tgttatgtca ataatatcaa aattaactgc tttaatctta
     7621 tatatgtctg acttaacttg agaaatattt attatattat ctattaatct caataatcta
     7681 aacatatttt gtttagttat ttttatatgt tcttttagta tatcctgaaa atcaattatt
     7741 tttccttttt tataaaggtt ttcaataagt tgaactgaac tatatatatt atttaaaggt
     7801 gtcttaagtt catgagatat attagcataa aactccatct tcatttggtc atactgtctt
     7861 tgttttatta atgctttttt aagtctttca gactctcttt gcacacttaa atctttaata
     7921 attctcactc tacttctttt ctgtccaaag tataatgttc ttgatatcat ttttacttct
     7981 ttaatgtgat tattttcatt tactatatgg atactcttct ctctttctcc tatatttaaa
     8041 ttgtttatgt atttttttac taatatattt ctatattttt gtgttgtaac tcctaataca
     8101 tcactagaaa ttccgaacaa ctctctaaag gctctatttg tatatagtac tcttgatgta
     8161 cttaaatcct caagaaaaat agcctctggt ataacatcca gtaatttttc atatattatt
     8221 ttttgttcat ttactgttct aagaatattt atctctttag ttatatctct aaatgtaagc
     8281 aatttaaaga gtttattatc tgaccaatag tctccaactc taacttcttc aacatgttct
     8341 tcaccttctg agtcagacat cacaaaatta actatacagt ttgctgtgtc attgtaactt
     8401 actatttcag ctttcttttc ttgtgttaga tttaatcttt taaattccct attgtcaaag
     8461 aaatctatgt taaaagtttc aaaatattgt tctaatgtca tatcgactaa atcacttgaa
     8521 acacatttaa aactcttttc atatttttta tttatactta ttaccttatt cttctttatg
     8581 ccaccttcag cacttcttac aagtatagga gatggaatat ttagtataat gttttcatag
     8641 tctttattta tatttcttat ttcttcatct attttgattt catttgtaat atcatttaaa
     8701 cttattaagt aattgctttc gtctttatta ttacttaaac ttaacaaata aattttatca
     8761 tttaactcta ccagtttatc aattatactt atatcgttat caaatttctt caatttttca
     8821 gcaacttttt catcttcctt tataaaagtt aatattttat aataattatt catatccttt
     8881 gaaaattcat ctttaaattt attatttgtg taacttatat taaaatcata gtctgttact
     8941 atccatacat ttggtattgt atccagagct tgtctaagta attcttttct ctggtctatg
     9001 tagtttttta atgttctttg tataatcata tccttttcta ttgctaaatt tatctttcct
     9061 aattgctctg actttttact taatttttta ttgattgaat caagttcata atatggatac
     9121 actactctat tattaagact gtatacatat acataataag tatggttaca taatagtaaa
     9181 tatattactc ctattaatct atctgaatct actatattaa tcttagaaat tgctacaaaa
     9241 catataatag ttgtaaaaaa aacaaaatat gttaaatctt ttattaactt atagtgctca
     9301 atgttactat caagtttatt caacaaatat agtaaattaa acatagatat acaaatatta
     9361 attaatataa taatcatatt ccagttaata tcactaaaaa tatttcttat aaagtaatct
     9421 aatatcacaa aagcactata aaaaattagt attgggctta ttcttagttt ttttacttta
     9481 gaaatggtta agtatataaa agtagacata ttaattatgc ttaagttaag caatacaatt
     9541 tggaattttt gaatttttaa atttactact cctaaaatac ttacaaaaac taatacaaga
     9601 caccctactt tcaatatatt tataaattca tctgttttaa agctacttat ataaactata
     9661 gaatatccaa atatccaaag taaaattatt ctatacatat ttatagaaac tgtatacaaa
     9721 tttatattta aaagtgcaat aaccaaaaat aacccattag ctagtatata gaccttattc
     9781 ttacttaaag ttcctttaga ttccatattc cccaccactt cttcattttt atatagtttt
     9841 acctataaat atgttaccac aattcttcca aaaaatttgt cactttctag ttataaaaaa
     9901 aaatgagtaa atatttttaa ttttactcat tttgtagatt ttgtatattc agtttaaaaa
     9961 gctggaacta tacttccttt atattcatct tgtataaatt ttttaacttc tttactattc
    10021 atagcctctg ataaagcctt aatcttatca ctatctttat tattttctct acaagctatt
    10081 atatttacat atggagaatc acttgattct attactattg catccttagt aggatttaag
    10141 ttagctgtta aagcataatt agaatttatt actgctccgt caacatcttt taatactgtt
    10201 ggtaattgct ctgcattcat ttcttttatt actatatttt taggattttt agttatatct
    10261 tttttagtta taagctctcc atcttttact tctatcaatt tattttttgc taataattta
    10321 agtgctctag ctccattagt tgcatcattt ggcacagcta taacagctcc atcttttaat
    10381 tcatctaatg acttaacttt ttctgaatag aatcccattg gctctatatg aactttagat
    10441 gtataagtaa gtttatatcc tttctccttc acagtttcct ctaaaaatgg aatatgttga
    10501 aagaagttag catccaaaga cccttcatct aaagctgtat ttggaagtac ataatcatca
    10561 aatattttta cttctaaatc atatcctttt tcttttaaca aaggttttgc aacttccaat
    10621 atctttgcat gtggatttga tgaagctcct actagtattt ttttatcctc tttgtttgaa
    10681 caacctactg ctgatattgc tattgctgac accaatgcta ctgataataa tttctttaat
    10741 ttcattttta ctccccctct ttaaaatgtt tataattaat ttattttagt ttcttataag
    10801 ccagatttcc tactccctgg attatctgaa ctaatattat aagtgctatt acagtatata
    10861 ccattactgc tgtatcaaat ctttgatatc cataaataag tgctatatta cctaatcctc
    10921 cagctcctac tgcacctgcc atagctgtat aaccaagtat agatattatt gataatgtaa
    10981 ttccagatac tattgaaggc atagcttcct ttatcataac tttaaatact atttgtcttt
    11041 ttgtagctcc aaaagatttt gctgcttcta tcaatccttt atcaacttca tttaatgagc
    11101 tttctataat tctagcgata aacggtgctg ccccaatagt tattggcact attgcagcag
    11161 tttcccctat acttgttcca acgattaatc tagttattgg aatcattgca actataagta
    11221 tcataaatgg gaaacttcta aatatattta ctataaatcc taatgcacta tttattgtgc
    11281 tatttggttt taatccatct ggttttgtaa ctactaatat gattgctaat ataaatccta
    11341 atattgttgc cactatagtt ggtactataa ccatatacaa agtttgtaac aatgcatttg
    11401 gaaatagtgt tgttaaaaag tcaattaaac tattcattta tcatttcctc ccatcttatg
    11461 cccttactag ttagatattg ttttacttgc tctccacttt tatctgaaat gtttataata
    11521 agtgaaccta aaatatcatc tttaaattgt tctaatttcc caaatattat agacacatct
    11581 atatttagtt ctcttgccat agtcgtaata atagcttcat tagaaatatc tttagggaat
    11641 agtatcttta tatttgttcc ttttggcaat attatacttt cttcacctat taattttcta
    11701 agtcctttag tatttcttaa gaatatttct tctgtatctc ctacctctaa tacttctcca
    11761 ttttccatta ttgctactct tccacaaatc tgctttataa cttccatttg atgagttaca
    11821 actattattg ttattcccaa ttttttattt atatcttcaa gcaatgaaag aattgacttt
    11881 gtagtatttg ggtctaatgc tgaagtcgct tcatcacaaa gaagtacttg tggatttagt
    11941 gctaaagctc tagcaattgc aaccctttgt ttttgtccgc cacttagatt tctgggttta
    12001 tcatttttct tttcagatat tccaactact tctaataact ctaaaactct ttttttaatt
    12061 tctgcctttg agtatccaaa acattctaat ggcaatgcta cattatcaaa tacagttttt
    12121 ctttcaagca atgaaaagtg ttgaaaaatc attcctaact cttttcttaa atctctcatt
    12181 tgcttttcat tcaatgactt tacttcttta tcagaaacaa gtacactgcc ttcttggtat
    12241 tcttctaatc cgtttataca tctcagtagt gttgatttcc ctgcaccact atgacctatt
    12301 attccaaaaa tttctccaga ttctatttca atacttacat ctttaagcac ttgaatcttt
    12361 ccataatact tattaacatt ttttatgcta atcataaaat ttcctcccat atattctgct
    12421 cagtttttat gtttatcctc tcttatgtat tacaacaaaa taaaagcccg agtataaact
    12481 caggcttaga aagctattta tactcatcta tcaactatat tagttgcagg atttagcacc
    12541 aatgtatata aaatatactg gttgccgggt ttcaaagggc cagtccctcc accactcttg
    12601 ataagacgtt atttaattta attctattat catttgttgc tatgttatat atgatatatt
    12661 cattaatagt atttgtcaat aaatttattt aaatttttta ttttttatta tcgtta
//
LOCUS       DAEQCW010000104        12626 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.105, whole genome shotgun sequence.
ACCESSION   DAEQCW010000104 DAEQCW010000000
VERSION     DAEQCW010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12626)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12626)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12626
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.105"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(117..1997)
                     /locus_tag="KRO40_002923"
     CDS             complement(117..1997)
                     /locus_tag="KRO40_002923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp10"
                     /protein_id="HBH2093733.1"
                     /translation="MSKRKSFIRTIAVSTMAVAVTGSATCAYAAPVLQGTKTYEKVNT
                     IDISVDSVENIVYSFQASIKVQGEVEVVDNEQKEKITWSDNIKSQIKSGNANATCRVE
                     YNKSSNTTTLDIYVTSNEDLLDGNRLNIGRISVKKSGSNSNADYKVLGKGTNDKPALK
                     IVTYNNKTVDYENISSDEGLIFTLINESEVKPIGGTGSSKNDPEKYKVEKSEALEYLL
                     NNIRINYSIVSKETQESGSNVILKLGLAQKTTKGRKATINKYVEVTLPKSLEYIVENE
                     LSKPDELPPDNGNGGNNGGGSNSGGSSSGGSSGGGSSSDSTSNVTVKKLKGADRFETA
                     IKISQSGWTKSDTVVIVNGEDKSMVDGLTATPLASVKNSPILLSSNEKLPQKTVEELK
                     RLNPSKVIVIGGNNSMPNSVVEAIKAVNSKISVQRIGGDTRYQTSINIAKEIDKTNNV
                     SKLYIGAGNGEADSLSIASLAGKEKTPIVLTQKDGVDNEAEQFIKSNKVSNIYFIGGV
                     EKISNKAIEQVGKIANKDISNNRVAGQTRQETNAKVIDKFYSQSKLDGVVVANQDKLI
                     DALAVGPLAAKNNSPVILATNTLDKSQESSLKGKNSSKLFEVGGGIASSVIDKIKSLI
                     EK"
     gene            complement(2201..8164)
                     /locus_tag="KRO40_002924"
     CDS             complement(2201..8164)
                     /locus_tag="KRO40_002924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-binding adhesion protein"
                     /protein_id="HBH2093734.1"
                     /translation="MKKAISCVLAVSMCSAPLNVFAEPILEGKLRAVEKSVTEKLRGS
                     LEVDLNFSLPIKNSESESMTNMQLRLKDDSNNSGIIKLGEKDSGTVNVGTDNIEYTIK
                     KLSASRSEIKNKDENISYYNIVFNNLPVGKYNVEVSGDGFKNKEIKDIDISSYSQRVL
                     LSNRASVDNKNKPLNYELFLMGDVNGDGKVDKSDYNKVLENIDSNKREFDLNRDGKVD
                     IVDLDYVQKNLGQSEDAKSLESIVSTNPIVDTSKVELKGNSDVDINGNVENLFSGENN
                     GVTISSKNDEISEEKPAVMDIALSEALNMEVINIKAPEGTAPAKGIVEVTDKDGNVQQ
                     IPYENKEYMKNLKDEEQQEEVNNEQEEVNQEEVNNKDENINQTDNNSNNKDENNDKQQ
                     ENSDKQEANSNTNQDKNNDKENSSMDKPNSDEDTPKEEGNISKDDNSTTSTYSRSALE
                     TYADVQNSDIVINLGKQVAVKKITIKITATTANDRNLAEISKVEFLNNVYKEIPKPEM
                     NIPKINKISTSTAVGNEKVSFYWNNEVNVSAYELILDKIDSKGKVLSTKKLQTSKNTI
                     EVRDIEAYGLYRVSIQSLNGDWSSGYKDATPENLDGVPENVDSNYKPIQFSPDSILEF
                     QVVPDTKPEPPEGINVKGKFKSLDVSWKNHKQAKDFDLYYKEKGSNGSWIKYNDKLIR
                     GTSSKIEGLKDNTTYEVRMTATNHLGTSGMSKTYIGTTESMDAPTTPNYRLINTPKEN
                     GGFGIPTNHIVDVVYPDGYDKSEYSDKNPFDKFNVVDGDFTTHWTFPTYNAAEGTNRG
                     PIITFDKSYTMDTFMATPRFDVSDKTINDFEVRYWDENGQLHNLGDVPFETKTDPVNN
                     NKYVMVRLKEPITATKIQVSVCSSYSYKSNISELKFYEYDSIEDDVRNLFMDGLQVEL
                     KEDVTQEKITELKDRLNTPDKASGEYHPYKTVIERELKLAQDLYNDRATLTDVTTVNQ
                     EINKLGKYKDKNGQYTVNSNNLGMQNDWQALGVAARAGDEITVYVGSKSGKTPKLIYT
                     QYYGESGAYKSGEINLNTGKNVIQLSKLHSLDIECGGSLYIRYAEDTPSGGDIKVRVA
                     GATKIPHLNLNGTINDKSPAGVSESKKKIKAYIEELAKYKDAVKGEPYYPGTNVGNSY
                     GYSEKTGVLNTTDIESDKVTLNVPATAVYQEISKGNSDLNTQVDRLYNSMLAWEQIMD
                     LVYSERGVFKTQDLDGNGTVDDNEFNLTKNDMAPKSRMNIKYQRMFIGAFMYASGLHV
                     GVEYGSVPGLMNGVPFQIDDSGKATGGNLFGWGIGHEIGHVTDIGKMTYSETSNNVLA
                     LLAQTFDDKTHSRLEGSTMDKIYEHVTSNSLGIPSNVFERLGMLWQLHLAYDDDFTGS
                     MLKNNSDADLSNDTFYAKISRKYRALSSSDPINSLPKDQMLVAMASSVVEKDLRDYFK
                     AWGVEITPELNSIMDSKNYEKESRKIQYVNDEARRKILNENIASMAKDTKVSASFSDG
                     IQSGSLVKSNKISIDLDVDKDKDKILGYEIIRSDGNYLDGENGTQVKYRTVGFVDAKG
                     NSKTKFTDNISPLNNRAFTYKVVAYDYHLNPTEEFEVGTVKLSDEGKINKSAWSFITN
                     TVSDGDVRTENDSHGPLQNPEIDNIKDNDASTTYKGKIISKAEWNKDPQKDPDINVEE
                     NPYIIVDMKETLPIVGLKYTKPETEARKFSLKGLFNFRKNTSTTYNPLTNYKIQVSND
                     KKNWEDVSQGTFEYGQDLVGGGKDQDNEARVTFNKDGKLWTYQARYVKLISNNKSNIE
                     VAELDIIGPPGDNIEIGIINNADETRTNGIGKLAEDYVYQSDDSSTSEDETGKIPAGS
                     IVITGEYSGNPAFNLPLLIDKNNKTISGEALLFAEVPEKGELGEISKGTWVYYMPKEN
                     FDSLSDKVKAELYRYNDLQGDTPVGQRFVSDTMYVPVGAKNYDELKTISLTDSNSKAR
                     KATRNSIDISNKKVITVSNKVKGNIVRDK"
     regulatory      complement(8288..8373)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            complement(8545..9948)
                     /locus_tag="KRO40_002925"
     CDS             complement(8545..9948)
                     /locus_tag="KRO40_002925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp9"
                     /protein_id="HBH2093735.1"
                     /translation="MKNSKKILAIGLTLFLVMVNTPMVNALTSVEQIKGNDRYETAAK
                     IADKQNYNTAILINSDNSLADGLSASGLAGALNAPILMTKQNQIPNTTMERLNKAKTV
                     YIIGSESTISKNVENQLLSKKKVVQRIFGENRFDTSIKIAEKIKEIKPIDKVIIANGF
                     TGEADAISASPVAARDGVPIILTDGNSVGFDTTGLKSYALGSSEIISDELVKSTNSIR
                     LGGTDRFETNKIVIQEFYKNSKEFYLSKGLQLTDALAASTIAKNAPVVLVENGSNKSI
                     LSGADKLTVLGGINQNVIKQCINQASPNQQGLYYNPNDRAFKERIKGKVYALTKQYRK
                     ENGVRALSVASRLEGLANDWSNLMANKKTLSHTINGKNSYSTFLKYLDWSEIKPGYIA
                     VQGENIIKYKIPDKPVYTNRDADDIGNFIFNEWKTNPEEGTNMLHKGYEIMGFGIAIT
                     GDKNLYATHEFYGRYKE"
     gene            complement(10410..12305)
                     /locus_tag="KRO40_002926"
     CDS             complement(10410..12305)
                     /locus_tag="KRO40_002926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp8"
                     /protein_id="HBH2093736.1"
                     /translation="MLSNKKRSMAIVMAGATVMSAAAPIFADNTVTENVDKNYTVSAK
                     DSAKLIEEVRKALEVKFEDTKAGANVNDRVYDIKVDNVNLTNATQLQNKINSLTEGQS
                     LKVTIQDKGHQVLGGKVVDYKIENYKTAQEIVDAVNAYNATLAEDSDNKLTATIKSTN
                     TVEVKRAKDSANVITLNVGDQHLDFSKVITSEEGTFEGYEKSYSDIDSKELHTITVKN
                     ADLQDISAEELFDGIRLTTLGREIVNKVKNGYALTFENEAILTQEQEDSDDKDKPEKS
                     SFDIVLSKANEKPETISVSSKNHKLVRDLHKVLTDVKDGKELKVEVLSGDSRFTTAVE
                     VSKERFKDGEAEAIILVGEDAIVDGLASAPLASQKNAPILLSKKDSLPSEIEAEILRV
                     LGSNLSSKKIYIVGGESKVSKETEEKLSKLGVSKVERVSGEDRFETSLEIAKQLKDTF
                     KTAFVVGGNGEADAMSISARAAQFGAPIIVTGNELDANAEKLLKGKELEIVGGENSVS
                     KEVEDKLVDIDLNNKVERLAGENRKDTNAKVINKYYAGATKAYVAKDGYVGGNGQLVD
                     ALTAAPLAASSKAPIVLTTEELSKSQEEVVELRLKNATKLVQIGEGIAKNAIEKIAEK
                     INLFTKN"
BASE COUNT         3483 a         2328 c         1403 g         5412 t
ORIGIN      
        1 tatacatttt aacctcaata ttattagatt gttaagataa tgaaaataaa ataagaatgc
       61 atttaaatat ataactttat atctaaatac attcttattt tctatttact taatatttat
      121 ttttcaatta aactcttaat cttgtctatt acagatgagg ctattcctcc acctacttca
      181 aacaactttg atgaattttt accttttaat gacgattctt gtgatttatc taacgtattt
      241 gtagcaagta taactggtga attgttttta gctgctaatg gtccaactgc taaagcatct
      301 ataagtttat cttgatttgc aactacaact ccatctagct tagattgaga gtagaattta
      361 tctattactt tggcattcgt ctcttgtcta gtttgacctg ccaccctatt gtttgatata
      421 tctttgtttg ctatttttcc aacttgttca atagccttgt tagatatttt ttctactcca
      481 ccaataaaat atatatttga caccttattt gatttaataa attgttcagc ttcattatct
      541 acaccatctt tttgtgtaag tactattgga gttttttctt taccagccag tgatgctatt
      601 gataatgaat cagcttctcc atttcctgct cctatataca acttgcttac attattcgtc
      661 ttatctattt cttttgctat attaatagaa gtttgatatc ttgtatctcc acctattctt
      721 tgtactgata tttttgaatt tacagctttg atagcttcaa caactgaatt tggcattgag
      781 ttgtttccac ctatcacaat tacttttgat ggatttagcc ttttcaattc ttctacagtt
      841 ttttgaggaa gcttttcatt tgatgataaa agaattggtg agttttttac actagcaagt
      901 ggtgtagctg taagcccatc caccatactt ttatcttctc catttactat tacaactgta
      961 tctgattttg tccaaccact ttgagatatt ttgatagctg tctcaaatct atcagcacct
     1021 tttaattttt tgactgtgac attagatgta gaatcacttg aacttcctcc tccagagctt
     1081 ccaccactag atgagccgcc tgaattactt cctccaccat tatttccacc attgccatta
     1141 tctggtggta attcatccgg ttttgataat tcattttcaa ctatgtattc taaacttttt
     1201 ggaagtgtaa cttcaacata tttgtttatt gtagcttttc ttcccttagt tgttttttgt
     1261 gctaatccaa gttttaatat tacatttgaa ccactttctt gtgtttcttt actaacaata
     1321 gaatagttta tcctaatatt gtttaataaa tattcaagtg cttcactttt ctctacctta
     1381 tacttttcag ggtcattttt actagaacca gttccaccaa ttggttttac ttcactctca
     1441 ttaataaggg taaatattaa tccttcatca gagcttatat tttcataatc cactgttttg
     1501 ttgttatatg ttacaatttt taaagctggt ttatcatttg ttccttttcc taaaacttta
     1561 tagtcagcat ttgagttact gccagatttt tttacagata ttcttcctat attcaatcta
     1621 tttccgtcta gtaaatcttc atttgatgta acatatatat ctaatgtagt tgtattactt
     1681 gatttgttgt attctactct acaagtagca tttgcatttc cactttttat ctgagatttt
     1741 atattatcag accaagtaat cttttctttc tgctcattat ctactacttc aacctcacct
     1801 tgtactttta tactggcttg aaatgaatat actatgtttt ctactgagtc cacagatata
     1861 tctatagtat ttactttctc atacgttttt gttccttgta aaactggagc tgcatatgca
     1921 catgtagcac taccagttac agctactgcc atagttgata ctgctatagt tcttataaaa
     1981 gattttcttt tactcattaa cacccgtcct tatctatcat taactaagtg gataaattta
     2041 cttatccacc tagcttttat atttaattta taaattaccc taaatttatg gttacattta
     2101 tatactttac ttttaatatc tactatttta aaactattct agtacctaat cttattagat
     2161 atacaatgtt agtattttta cgtttttaga gttccaccta ctatttatct ctaacaatat
     2221 taccctttac tttattgctt acagttataa ccttcttatt actgatatca atagaatttc
     2281 ttgtagcttt tctagcttta ctattactat cagtaagact tattgtcttt aactcatcat
     2341 aattcttagc tcctacaggt acatacattg tatcacttac aaatctttga cctactggag
     2401 tatctccttg aaggtcattg tatctatata gttcagcctt aaccttatca cttaaagaat
     2461 caaagttttc ttttggcata tagtaaaccc atgtaccttt actgatttca cctagttcac
     2521 ctttttctgg aacttctgca aataaaagtg cttctccaga tatagtctta ttgtttttat
     2581 ctataagtag tggtaaatta aatgctggat ttccactgta ttcacctgta ataactattg
     2641 aacccgctgg aatcttacct gtttcatctt cacttgtgct agagtcatca ctttgatata
     2701 cataatcttc tgctaatttt ccaattccat tagtacgagt ttcgtctgca ttatttatta
     2761 tgccaatttc tatattatca cctggaggtc ctattatatc taattctgca acttctatat
     2821 tagacttatt atttgagatt agttttacat atctagcttg gtatgtccaa agtttaccat
     2881 ctttattaaa tgtaactcta gcttcattat cttggtcttt tcctccacca actaaatctt
     2941 gtccatattc aaaagttcct tgacttacat cttcccagtt ctttttatca ttacttactt
     3001 gtatcttgta attagttaaa ggattgtatg ttgtgctagt attctttcta aagttaaata
     3061 atccttttaa tgagaacttt ctagcttctg tctctggttt tgtatatttt agtcctacta
     3121 taggtaatgt ttctttcatg tctactatta tatatggatt ttcttctaca tttatatcag
     3181 ggtctttttg agggtctttg ttccactctg ctttacttat tatctttcct ttatatgtag
     3241 tacttgcatc attatctttt atattatcaa tttcaggatt ttgtaatggt ccatgtgagt
     3301 cattttcagt tctaacatca ccgtcagaaa cagtatttgt tatgaatgac catgctgatt
     3361 tatttatttt cccttcatct gataatttta cagtaccaac ttcaaattct tctgttggat
     3421 ttaggtgata atcatatgca actaccttat atgtaaatgc tctgttatta agaggagata
     3481 tattatcagt aaatttagtc ttgctatttc cttttgcatc cacaaatcca actgttctgt
     3541 attttacctg tgttccattt tcaccatcta aataatttcc atcacttctt attatttcgt
     3601 atcctagtat cttatcttta tccttatcta catctaggtc tatagatatt ttattagatt
     3661 taactagaga accactttgt attccatcag aaaaactagc acttacttta gtatcttttg
     3721 ccatactagc tatattttca tttaaaatct ttcttctagc ttcatcattt acatattgta
     3781 tctttcttga ttctttttcg tagttcttgc tatccattat actgtttaat tctggtgtaa
     3841 tttctactcc ccatgcctta aagtaatctc ttaaatcttt ttcaacaaca cttgatgcca
     3901 ttgctactag catttggtct tttggtaaac tattaattgg gtcactactt gaaagtgctc
     3961 tgtattttct tgaaatcttt gcatagaatg tatcattact taaatcagca tctgagttat
     4021 tctttaacat tgaacccgta aaatcatcat cataagctag atgtaattgc cataacattc
     4081 caagcctttc aaatacattg cttggtatac ctaagctatt tgaagttaca tgctcatata
     4141 tcttatccat tgttgaacct tcaagtcttg aatgtgtctt atcatcaaag gtctgagcaa
     4201 gtaaagcaag tacattgtta ctagtttcgc tatatgtcat ctttccaata tctgtaacat
     4261 gtcctatctc atgacctatt ccccatccaa ataagtttcc tcctgtagct tttccactat
     4321 catctatttg gaaaggtact ccattcataa gccctggaac tgaaccatat tctactccta
     4381 catgtaatcc agaagcatac ataaatgctc caataaacat tctttggtat tttatgttca
     4441 tacgagattt tggagccata tcatttttag ttaagttaaa ttcattatca tctacagttc
     4501 cattaccatc taaatcttgt gttttaaata ctcctctttc tgagtaaact aaatccatta
     4561 tttgttccca tgcaagcata ctattatata atctatctac ttgtgtattt aaatcagaat
     4621 ttccttttga tatctcttga tatactgctg ttgcaggaac atttaatgtt actttatcac
     4681 tttcaatatc tgtagtgttt aacacaccag ttttttctga atatccatat gaattaccaa
     4741 catttgttcc tggataatat ggttctcctt ttacagcatc tttatattta gctaattctt
     4801 ctatatatgc ttttatcttt ttcttagatt cagaaactcc cgcaggactc ttatcattta
     4861 ttgttccatt tagattaaga tgtggtatct tagtagctcc tgctacacgt acttttatat
     4921 ctcctccact tggagtatct tcagcgtatc ttatgtataa acttcctcca cattctatat
     4981 ctaaactatg aagtttgctt aattgaatta cattttttcc agtgttaaga tttatttctc
     5041 cactcttata tgcaccagat tctccatagt actgtgtata tatcaactta ggagtttttc
     5101 cacttttact tccaacatat actgtgattt catctcctgc tctagcagct actcctaatg
     5161 cctgccagtc attttgcata cctaaattat tggaatttac agtatactgt ccgtttttat
     5221 ctttatattt tcctaattta tttatttctt gatttacagt agttacatca gtaagtgtgg
     5281 ctctatcatt atataagtct tgagctaatt ttaattctct ctcaataact gtcttatatg
     5341 gatgatattc tccactagct ttatctggag tatttaatct atcttttaat tcagttattt
     5401 tttcttgagt tacatcttct tttaattcaa cttgtaggcc atccataaat agatttctta
     5461 catcatcttc tatactgtca tactcataaa acttaagttc tgatatatta gacttatatg
     5521 aataggatga acaaacactt acttgtatct tggtagcagt tattggttct tttaatctaa
     5581 ccattacata cttattatta tttacagggt ctgtctttgt ttcaaaagga acatccccca
     5641 gattgtgtaa ttgaccattt tcatcccaat atcgtacctc aaagtcattt attgtcttat
     5701 cagaaacatc aaaacgaggt gtagccataa aagtatccat agtataagat ttatcaaaag
     5761 ttattattgg tcctctattc gttccctcag ctgcattata tgttgggaat gtccaatgtg
     5821 ttgtaaagtc cccatctact acattgaatt tatcaaatgg atttttatca ctatattcac
     5881 ttttgtcata tccatctgga taaacaacat ctacaatgtg atttgttggt attccaaatc
     5941 caccattttc tttaggagta ttaattaatc tatagttagg tgttgttggt gcatccatgc
     6001 tttcagttgt acctatatat gttttagaca ttccactagt tcccaagtgg ttagtagctg
     6061 tcattctgac ttcatatgtt gtattatcct taagaccttc tatctttgaa cttgtcccac
     6121 gaataagctt atcattgtat tttatccaag acccattaga gcctttttct ttatagtaca
     6181 agtcaaaatc tttagcttgt ttatgatttt tccagcttac atcaagagat ttaaatttac
     6241 ctttaacatt tataccttct ggtggttctg gttttgtgtc tggaacaact tgaaattcta
     6301 atatactatc tgggctaaat tgtataggtt tatagtttga atctacattt tctggtactc
     6361 cgtctaagtt ttctggtgtt gcatctttat aaccactaga ccaatctcca tttaaagatt
     6421 gtatgctaac tctatatagt ccatatgctt ctatatctct aacttctatt gtatttttac
     6481 tagtttgtaa ttttttagta gataatactt ttcccttact atcaattttg tctagtataa
     6541 gttcgtatgc tgatacattt acttcattat tccaataaaa agatactttt tcatttccaa
     6601 cagcagtgct agtcgatatt ttatttattt taggtatgtt catctctggc tttggtattt
     6661 ctttatatac attgtttaaa aattcaactt ttgatatttc tgcaagattt ctatcgtttg
     6721 ctgttgtagc tgttattttt atagttatct tttttactgc tacttgttta ccaagattta
     6781 ttactatatc actattttga acatctgcat atgtttctaa tgctgaccta ctatatgtag
     6841 atgttgtaga gttatcatct ttactgatat taccctcttc ttttggagta tcttcatctg
     6901 aattaggttt atccattgat gaattttctt tatcattatt tttatcttga ttggtattag
     6961 agtttgcttc ttgtttatcg ctattttcct gttgtttatc attattttca tctttattat
     7021 ttgagttatt atcagtctgg tttatatttt catctttatt atttacttct tcttgattta
     7081 cttcttcttg ttcgttattt acttcctctt gttgctcctc atcttttaag tttttcatat
     7141 attctttgtt ttcataagga atctgttgaa cattaccatc tttgtcagta acctcaacta
     7201 ttccttttgc tggagcagta ccttctggag cttttatatt gatgacttcc atattaagtg
     7261 cttctgataa agctatatcc attactgctg gtttttcctc agatatttca tcattttttg
     7321 aagatattgt aactccatta ttttctccac taaataaatt ttctacatta ccattaatat
     7381 ctacatcact atttcctttt aattcaacct tacttgtatc tactatagga ttggtagata
     7441 ctatactttc taggcttttt gcatcttcac tttgtcctaa atttttctgt acataatcta
     7501 agtcaacaat atctaccttt ccatctctat ttaaatcaaa ttctctttta tttgaatcta
     7561 tattctctaa aaccttatta taatcactct tatctacttt accgtctcca tttacatcac
     7621 ccattaagaa caattcataa tttaaaggtt tatttttatt atctacactt gctctattgc
     7681 ttaataagac tctttgtgaa taacttgata tatcaatgtc tttaatttct ttgttcttaa
     7741 atccatctcc agagacttct acattgtatt ttccaacagg taaattatta aatacaatat
     7801 tataatatga tatattctca tctttatttt ttatttcact tctacttgca gataattttt
     7861 ttatagtata ttctatatta tctgtcccaa catttactgt tcctgaatct ttttctccaa
     7921 gctttattat tccactattg ttactatcat cttttaatcg taactgcata ttagtcatac
     7981 tttctgactc gctatttttt attggcagtg aaaaatttaa atctacttca agactccccc
     8041 ttaacttttc tgtaactgat ttttcaactg cccttagctt cccctctaat ataggttctg
     8101 caaaaacgtt tagtggtgca ctacacatag atactgctag tacacaagat attgcctttt
     8161 tcatgaaata acaatcctcc cttaataaat atctaatttt tcatgaattt aaatactata
     8221 agtttcagac aataaaaaaa gacactcaaa gagaatctta attataaaat aaaaagactt
     8281 tactcttttt agcaactggc tgatatggct ttaaaagctt taatccctat agttttgcgt
     8341 cattagattt ccctaatttt gccatttaat tttcactact ttcttaccca ttttatacta
     8401 tatttaaact ttttaatata atttttttag attaaattat aaaaaaataa catttatatt
     8461 aatttattaa tataaatgct attttccatt ataatttaat tatttatata gcttccttac
     8521 aagcataatt ttgtgtatat tttcttattc tttatatctt ccataaaatt catgtgtagc
     8581 atatagattc ttatctcctg ttatagctat accaaatccc attatttcat accctttatg
     8641 caacatatta gttccttctt ctggatttgt cttccactca ttaaaaataa agtttcctat
     8701 atcatctgca tctctatttg tatatacagg tttatctgga attttatatt taattatatt
     8761 ttcaccttga actgctatat atccaggttt aatctcactc caatctaagt atttcaaaaa
     8821 agtagaatat gaattttttc catttatcgt atgagataaa gtcttcttat ttgccattaa
     8881 attagaccaa tcatttgcta gaccctctaa tctgcttgct acagataacg ctcttactcc
     8941 attctctttt ctatactgct ttgtaagagc atatacttta ccctttattc tctctttaaa
     9001 tgctctatca tttggattgt aatataaacc ttgttgattt ggtgaagctt gatttataca
     9061 ttgcttgata acattctgat ttatgcctcc tagtacagtc aatttgtctg caccacttaa
     9121 aatactcttg ttactgccat tttcaactaa aactacagga gcattttttg ctattgtaga
     9181 ggcagccaaa gcgtctgtta attgtaagcc tttacttaga taaaattctt tactattttt
     9241 ataaaactct tgtataacta tcttattagt ttcaaatcta tctgtgccac ccaatctaat
     9301 agaatttgtg ctcttaacta attcgtcgct tattatttca ctagaaccaa gcgcataact
     9361 ctttaagcct gtcgtgtcaa atcccacact atttccatct gtaagtatta taggtactcc
     9421 atctctagca gctactggtg atgcacttat cgcatctgct tctcctgtaa atccattggc
     9481 tataattact ttatctattg gcttaatttc tttgattttt tcagctattt ttatacttgt
     9541 atcaaatcta ttttcaccaa atattctttg tacaaccttc tttttggata gtaactgatt
     9601 ctcaacattt ttacttattg ttgattctga acctattata tacacagtct ttgctttgtt
     9661 taatctttcc atagttgtgt ttggaatctg gttttgtttt gtcatcaaaa taggcgcatt
     9721 taaggctcca gctaaaccac ttgcacttag accatctgct aagctattat ctgagttgat
     9781 tagtattgct gtattgtagt tttgcttatc tgctattttt gctgctgtct catatctgtc
     9841 attccctttt atttgctcaa ctgatgtcaa cgcatttacc ataggagtat ttaccattac
     9901 taaaaatagt gtaagtccta tagctaatat ctttttacta ttcttcatat tattttctac
     9961 ccccaatgta cttttcatat tttttattag tactcatact tatttttaat caaaagttac
    10021 aattttgtta ccatatttta tatatgatac catagttatc catacaactc aaacaatata
    10081 cctaaagttt ttattctcta taaattcaaa acattataat ttattttatt taattacgtt
    10141 ataagttcaa aataatttat gttagtaata tgtttaatca ttataagaag tatcttttta
    10201 taataatttt tgcaatatga atttctcaac attataatca aaaaataaaa taaggtatct
    10261 caatctaatt ctaaatgaga caccttattt ttattatttt atcttgttat ttgtatattt
    10321 tataatatct acactatgtc ttacatatta acgcattgta taatcatata ttatctaaat
    10381 aaacttttaa tattaattcc tatatcttat tagttcttag taaataagtt tattttttct
    10441 gctatttttt caatagcgtt tttagctatt ccttcaccta tttgtactaa cttagtagca
    10501 ttcttaagtc ttaactcaac tacttcttct tgtgatttag aaagttcttc tgtagttaat
    10561 actattggag cctttgaact agctgcaagt ggtgctgctg taagtgcatc aactaattgt
    10621 ccatttccac ctacataacc atcttttgct acatatgctt tagttgcacc tgcatagtat
    10681 ttattgatta ctttagcatt agtatctttt ctattttctc cagctaatct ttcaacttta
    10741 ttatttaaat ctatatcaac taatttgtct tcaacttctt ttgatacaga attttctcca
    10801 cccactattt ctaattcttt tccttttaat aatttttcag catttgcatc taattcgtta
    10861 cctgtaacta ttattggagc accaaattga gcagctctag ctgatatact catagcatca
    10921 gcttctccat ttccacctac tacaaaagca gtcttaaatg tatcttttaa ttgttttgct
    10981 atttctaaag aagtttcaaa tctatcttct ccagaaactc tctcaacttt acttacacct
    11041 aatttagaaa gtttttcttc agtttctttt gatactttag attctccacc tactatatat
    11101 attttcttag aagatagatt acttccaagt actcttaata tttcagcttc tatttctgat
    11161 ggtagtgaat cttttttaga taataatatt ggtgcatttt tttgagaggc aagtggtgct
    11221 gatgctaatc catcaactat agcatcttct ccaactaaaa ttatagcttc tgcttctcca
    11281 tctttaaatc tctctttact aacttctact gctgttgtaa atcttgaatc accagataaa
    11341 acttctactt ttaattcttt tccatctttt acatcagtta atactttgtg taagtctcta
    11401 actaacttat ggtttttact tgaaacactt attgtttctg gcttttcatt tgccttgctt
    11461 aaaactatat caaagcttga tttttctggt ttatctttat catcactatc ttcttgttct
    11521 tgagtaagga ttgcttcatt ttcaaatgtt aaagcatatc catttttaac tttattaact
    11581 atttctcttc ctaatgtagt taatctaatt ccatcaaata attcttctgc tgatatgtct
    11641 tgtaaatctg cgtttttaac tgttatcgta tgtaattctt ttgaatctat gtcactataa
    11701 ctcttttcat aaccttcaaa agtaccttct tctgatgtta tcacttttga gaaatctaaa
    11761 tgttggtctc ctacatttaa tgtaataaca tttgctgaat cttttgctct ttttacttca
    11821 actgtatttg tagattttat agttgctgtt aacttgttat cagaatcttc tgctaaagtt
    11881 gcattgtaag cattaactgc atctactatt tcttgagcag ttttgtagtt ttcaatttta
    11941 tagtcaacta cttttccacc taacacttga tgccctttat cttgaatagt aacttttaaa
    12001 ctttgccctt ctgttaaaga gtttatttta ttttgtaatt gagttgcatt agttaagttt
    12061 acattgtcta cttttatatc gtaaactcta tcatttacat ttgctcctgc ttttgtatct
    12121 tcaaacttaa cttctaatgc ttttctaacc tcttcgatta gtttagcaga atctttcgca
    12181 cttactgtgt aatttttatc aacattttct gtcacggtat tgtctgcgaa tattggtgct
    12241 gctgcactca taactgtagc acctgccatt actattgcca tacttctctt tttgttgctt
    12301 aacatattta tgtcctccga atattatttt ttatttttta tattcgtatt tcccacacat
    12361 aaataatatt atatataata ttatttttca atatatttta tgtgtttaca taatttacta
    12421 acacaaacac taataatatc ttcttgaaac ccttccccct acttaggctc tctataatta
    12481 tgctcaaaga tagaaatcct attttatagt gattttctac taaacaatca tatactaaca
    12541 aaagtattca aactccattt ttatatacta ctatgcacta atttttgctt tactcttatt
    12601 acttaaatat atatcactaa attaat
//
LOCUS       DAEQCW010000105        12595 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.106, whole genome shotgun sequence.
ACCESSION   DAEQCW010000105 DAEQCW010000000
VERSION     DAEQCW010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12595)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12595)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12595
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.106"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            69..1535
                     /gene="dndC"
                     /locus_tag="KRO40_002927"
     CDS             69..1535
                     /gene="dndC"
                     /locus_tag="KRO40_002927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA phosphorothioation system sulfurtransferase
                     DndC"
                     /protein_id="HBH2093737.1"
                     /translation="MAVNYLDNNNLENLYDEMQAVYLNDDRPWIIGYSSGKDSSCVVE
                     LTFRMLKRLPKEKRHKEIYVISSDTLIENPIILDYLKNNIDKINESATEHDLPISAQI
                     VYPELNDSFWANIIGRGYPTPKSIKYRWCTERLKIKPSNKFIKEKLEQKDVIVLLGVR
                     KEESSARKSRIEKREIEGYLLTPHETLRGKNKLAYVYTPIVNFSTADVWDVLYHQNDN
                     FIDFGGEFGPSPSTSWGTDAMELFQMYMKGSGDSDECPFIADEASAKSSCGNSRFGCW
                     ICTVVKEDKSLNGFIESGHDELKPLLEFRSWLISERDKPKNRKKHKRNGSVIKKDGRI
                     MFGPFTFEARQTILRKLLETQLEMQKFYPDLQLIQLGELKAIDDIWDNEEDLTGNILS
                     KIYKEVVGKNLPWSEYKKPVFDDLTLNIISEKCSEYDINIDLFNKLMIDTNKYKYFSN
                     NTKLKTSIERILNQQWLHQDIIEKIEEESNKELKYENK"
     gene            1522..3681
                     /locus_tag="KRO40_002928"
     CDS             1522..3681
                     /locus_tag="KRO40_002928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2093738.1"
                     /translation="MKINKLVLKNFRSYEEETTFNLNTTSEKNIILIGGKNGAGKSTI
                     FEAIKLCIYGPIAYKYQGFNSSYISRVKSNINNNSLRNSKVDTLVSVDIEISEGTEKN
                     TYTLIRQWTFKDKKLNETFSVYKNFSFTPLNADELNYFENYITSIISPKIFDFFFFDG
                     EHLYDFFIGKNSNIHLKESLLSLCNFDTFDILKKMLISTNRSNKNVSDEINIIKDDYL
                     NLEVEINNLNSQEKNLSYELEKISSEIEKLQQEQLKIKKEFRKKGGILAEEREMLNSR
                     IAELEGNRFIINQNIKDFCNDILPFLIVKKQILNLEKQLKVENDSILYSHLKDKLNIE
                     YIKNLLSDKIMSSSLDEIALTVSEALIEDIKPDSYEDNFESIHKLSNDESSKLLSLIN
                     TILNFDNNSIINSFGEHRSISNELADIRHKLNTSFKDETLNTYINDISSLSDKIDSLL
                     KSKNLLVTSLDKLRLEIAETITKRDKSKAKYIYLLQHNNIVDISSNLILMLDEIITTL
                     TETKIKLVQDNFMYIFKRIIQKDNFISSIDIDANFNISLYINKIYNSLELENLVENIG
                     SEEMEKKLGKLFFEDLFNLYRVKDKDDLFNAIKNNTQSTFLNLRTKVDIDEFSSGEKQ
                     IYILCLYWALLKSSEIEIPFIIDTPYARIDDTHRNNITSEYFSTISDQAIILSTNTEI
                     DEKSYKIIKPKLSNEYLIEYDNKNKKTIQNKGYFFEV"
     gene            3684..4067
                     /locus_tag="KRO40_002929"
     CDS             3684..4067
                     /locus_tag="KRO40_002929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DndE family protein"
                     /protein_id="HBH2093739.1"
                     /translation="MGFRLKTSIQTKEIFEELGSRMNLKPFALCKLAISISLSNSEPI
                     ENYESIDNNGLELNRQTITNQYDTLFKTLLEQHAGRHLSDDEYFPNQVKLHIDRGALM
                     LKNRYNYSSNLEHFITQIVQENNNL"
     gene            complement(4177..5319)
                     /locus_tag="KRO40_002930"
     CDS             complement(4177..5319)
                     /locus_tag="KRO40_002930"
                     /inference="COORDINATES: protein motif:HMM:NF014044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2093740.1"
                     /translation="MKIIFGNIKNNNKELIWDPTNSIKVPHPNTGIIGTMGTGKTQFT
                     KSLVTQIHREQKHNINGKPIGILIFDYKGDYIKDDFVDATSAKVYEIYHLPYNPLTLI
                     IPERIKPLLPVHTANSLKETIAKAFGLGPKQEVILRELIMKAYEKKGIKKDDENTWVK
                     SCPTMQDVLSIYLDDREIKKDDKLYAALSSFNDFEIFEPNSEKTKNLFDLINGVTVIN
                     LSYYDSGIQNLVVAITLDLFYSQMKALGSSDITGNGEYRQLNKMILVDEADNFLSRNF
                     TSIKNILKEGREFGVGTILSTQLLSHFSTSENEYQNYISTWIIHNVSDINNKDIRYIF
                     NSKNKSEEDNIYNKIKNLAKHESLVKMPSENSPIYIRDKAFWELNK"
     gene            complement(5329..9300)
                     /gene="dptH"
                     /locus_tag="KRO40_002931"
     CDS             complement(5329..9300)
                     /gene="dptH"
                     /locus_tag="KRO40_002931"
                     /inference="COORDINATES: protein motif:HMM:TIGR03237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA phosphorothioation-dependent restriction
                     protein DptH"
                     /protein_id="HBH2093741.1"
                     /translation="MSDQFYRYLAKNLVKYFESREIKSGDKFNIQFEREEQVKIMYDV
                     LEKESNSRPFTYNIMNGSKYQTFSMNVSGIQLIVASNNNTTNDFLIRLRNLIGNVASD
                     EFKDSAILFIHNMTLDSLIRGTESLQKEGMPFHTKTLVKDIQNKLENDKLKEDIKHIL
                     YFVLDRMNKSILEDNSSIFQYENILDILNKGRIEKSEYSKFGLFYDDNMLDNKSSKAI
                     KERLLDNEKLFSIVNSIHQYGDPKLELEKHFDSKGIDLLKDENWKYSTYKDIKSSQER
                     MKNKKVELLCIECVENLKLWSKPDIENKSKRKNILLFNKDKLDIINLCIKFDKKIEKT
                     SFSIDKMSKTYTEVKASGNKAYISININISETTFTKVKYNDGIIKYEFRICIVSCDEN
                     ILNDIKSNYGIVINSKRSMLVTNTDDDTIVINPKGIIERKIQIDEFENEINLEEGERL
                     DLELNVELEEDVEFIKIDVVYDQSVITIVKQEEKEQPISISGMKTWKLKRERKESFKY
                     LGNSKIVQGTSEYFPKENFKENLQIEKYIIENNIMHCTILEEKYKIIELDVDSRIKEA
                     YKNLISYYKVNDCIPSLAYYDVDLVNISKNYINTILEVFEDIKNGKVLSKERLNIAKV
                     GTIHRIDKEEELFLTPLHPVNVAYQLMINNVIGDEEVKEGILKLLGSKYLMPYIYKGK
                     NSLYKVVDQRHSPEWTYYVDHDMSRYKGSRDYVSKLTKEKINEFIEHFTYLFRDISKS
                     VMKIKLINLGDCKEVLLGIFDYYIKKLGKGEEINNLISIDIYIYGDKSIINSFEEIAF
                     YNSINDIKKHFNVNLSVDNYSEEDVLNLFRDKVKFYKKDKMSDLYEYSHLTLYQMDKD
                     VNITSSSMDDIKTGVALNGLIAGVPSIYLEDTYRTGFGSKFMATTKNELLNISMKFNS
                     LTKSIGTGDPFNDNLSVTTSISENNSSFLNKIYKTSHWVTFIDPKVDLNFFKDDENSN
                     DLLIIHYSDQYTTSSGYDAITVTRKSEQYKFIIEEFLNSKDIKVEEDTIPNLINYFNA
                     INGDWLLRLISSKSQFPREKLSILSAIKISLAYFYHPNIIWIPISLEEILRVSGGAGL
                     KQAGGLFTVKKLTGDTGSYSDDLLLVGIENKNNKIKVYFYPVEVKIGDNNESVIKKAI
                     IQANKTRDLIEEYLTESENDSQKFTKLMYRNFMIQLAIVSAQKMKLYHIWDEQNWDDI
                     INSDIRTNLLNDNYEISNDLDEFIGRGAVISFKKGTYYNGNLGKEGNITILNLSEQEG
                     YNNIVMDLEEMKEKYIRGESDFVIQEMLINKYLDNTIGIQNMDKNVILDTNVMLNKTK
                     DYD"
     gene            complement(9281..10702)
                     /gene="dptG"
                     /locus_tag="KRO40_002932"
     CDS             complement(9281..10702)
                     /gene="dptG"
                     /locus_tag="KRO40_002932"
                     /inference="COORDINATES: protein motif:HMM:TIGR03236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA phosphorothioation-dependent restriction
                     protein DptG"
                     /protein_id="HBH2093742.1"
                     /translation="MQLIINKEYFKQNYMIDKGIARHNSVKNIVILPYTTTTKEKSKL
                     KEKVERFESCVGEFCRLVYNKKMNIKERQLKDIKLLIKDINVNSSDDSVQLESIIREL
                     FLDEEENMYIFHPKLLNYIHMPSDSYYKKLSKFLYDVLLNSTDNITIKNKINKCFEYE
                     PDNIMELIILKNLPELENEETSKSIYKCICKNVSKLFQEDLEFMLNYPELIINEFERL
                     LKYYYFFYVSQLSIKLSHFFDGDRDRTEKVYFILSWEKASKTRISYNMGWKMLESHIR
                     ILFSHVHTLEILNTNNDISKYDYVDLNKIIKNLSENERLRLYENIIDIKNTYVKSITD
                     VQWDDYDEQTKVYKNDNIKEEICDLHKRIDYQFKKSSREANYKRYKNLFEEYCKLNFL
                     KKAGPLGNVLKINQEELLFMTKLCMKNKTKIKLKELFEEYEKRGIYFDRDSQSKVVEL
                     FEKLNIIEKKSDSGDAQYVRSIL"
     gene            complement(10690..12498)
                     /gene="dptF"
                     /locus_tag="KRO40_002933"
     CDS             complement(10690..12498)
                     /gene="dptF"
                     /locus_tag="KRO40_002933"
                     /inference="COORDINATES: protein motif:HMM:TIGR03238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA phosphorothioation-dependent restriction
                     protein DptF"
                     /protein_id="HBH2093743.1"
                     /translation="MSNGCLIDELKKLKESSKEAVENISDFSSFKKYMHVKRQVENEL
                     LDIIKYTADSNKAELILVCGGVGDGKSHLISYLNNKYPEIMSKFIIHNDATESFEPNK
                     TSIDTLNDVLDDFSDKKMDNSDKKLVLAINLGALSNFLESEYVNKFTKLREFVENKGI
                     LDISISDDDDKNSNFHFVNFSDYHIYTLNADKPKSRYIESIINKIIAEDNQNIFINSY
                     KTNCTHCIVNYKCPIKNNYEMLMRDSVRETLVDILIESTVKYKIIISTRSLLNFIYDF
                     IVNVDLDNKNNKDLIKFVEELSYEAFIKYIFVSNLYNHSELSQILNAVNKIDPINITS
                     ENLDNIIIKLSNTKDMTILFNQYLNLSKNSYLESSMTNREIIESALNSSKNELSRKIL
                     KYNIINTFIRLHIFIPKNNLQLRDNIYISYMRNLYYFNKGEKTYLSNLYDDIKEALYS
                     WNGRIQDDRINMSIGKNQMRYKISQRLNIIPDLSKLRKCTEEELHKFKPSLEIGYKND
                     EKENQDTCTVDIDFNLYKLLMRVKYGYTPNNNDKYTYINFVVFMNKIHKLGNQNRELY
                     IEDRLEDTVPKYKLTYDKEFDKFKFIRVNGVKVCNL"
BASE COUNT         4390 a         1807 c         1308 g         5090 t
ORIGIN      
        1 atataaatta aaataggagt attatgtaaa gatcttcgct atactcttat agaaaggata
       61 cttaatatat ggctgttaat tacctagata acaacaattt agaaaattta tatgatgaaa
      121 tgcaggccgt atatcttaat gatgatagac cttggataat cggatatagt tctggaaaag
      181 atagttcttg tgtagttgaa cttacattta gaatgcttaa aagactaccc aaagaaaaaa
      241 gacataaaga gatttatgta atctcatctg atacacttat agaaaatcca ataatacttg
      301 attatctaaa aaataatata gacaagataa atgaaagtgc tactgaacat gatttaccta
      361 taagtgcaca gattgtatac ccagaactta atgatagttt ttgggccaat ataattggta
      421 gaggttaccc tactccaaag tctattaaat atcgttggtg tactgaaagg cttaagataa
      481 aaccatcaaa taaatttata aaagaaaaac ttgaacaaaa agatgttatt gtactgcttg
      541 gcgttcgtaa agaagaaagt tctgctagaa aatcgagaat cgaaaaaaga gagatagagg
      601 gttaccttct taccccacat gaaaccttaa gaggtaaaaa taagttagct tatgtgtata
      661 cccctatagt caattttagt acagcagatg tttgggatgt actctatcat caaaatgata
      721 atttcataga ttttggtggt gaatttggac catctccatc tacctcatgg ggaactgacg
      781 ctatggaatt atttcagatg tatatgaaag gttctggtga ctcagatgaa tgcccattta
      841 tagcagatga agctagtgct aaaagtagct gtggaaatag taggtttgga tgttggattt
      901 gtactgttgt aaaagaagac aaatcattaa atggatttat tgaatctggt catgacgaat
      961 taaagccact tttggaattc agaagttggc taatttctga gagagataaa cctaaaaatc
     1021 gtaaaaaaca taaaagaaat ggctctgtca tcaaaaaaga tggtagaatc atgtttggac
     1081 catttacatt tgaagcaaga caaactattt taagaaaact tttagaaact caacttgaaa
     1141 tgcaaaaatt ttatcctgat ttacaactta ttcaattagg agaacttaaa gctatagatg
     1201 atatttggga taacgaagaa gacttaactg gtaatatatt atcaaaaata tataaggaag
     1261 ttgtaggcaa aaacctacca tggtctgaat ataaaaaacc agtatttgat gaccttactt
     1321 taaatattat atctgaaaaa tgtagtgagt atgatataaa tattgattta tttaataaat
     1381 taatgataga tacaaataaa tacaaatatt ttagtaataa tactaaatta aaaacttcca
     1441 tagaaagaat attaaatcaa cagtggcttc atcaagatat tattgaaaag attgaagaag
     1501 aaagcaacaa ggagttaaaa tatgaaaata aataaacttg tattgaaaaa tttcagatct
     1561 tatgaggaag aaaccacctt caatctaaat actactagtg aaaaaaatat tatattgata
     1621 ggtggtaaaa atggtgctgg taaatccaca atatttgagg ctataaagct atgtatatat
     1681 ggacctatag cttataaata tcaaggtttc aactcttcat atatatctcg agttaaatct
     1741 aatataaata ataattctct aagaaatagt aaggttgaca ccttagtatc agtagatata
     1801 gaaatcagtg aaggtactga aaaaaatacc tataccttaa ttagacaatg gacttttaaa
     1861 gataaaaaat taaatgaaac attttcagtt tataaaaatt tttcatttac accattaaat
     1921 gctgatgaac ttaattattt tgagaattat attacatcta ttatttctcc taaaatattt
     1981 gactttttct tttttgatgg agaacatttg tatgattttt ttataggtaa aaattcaaat
     2041 atacatctaa aagaatcttt attatctctt tgtaattttg atacatttga tattttaaaa
     2101 aaaatgttaa tttcaactaa cagatccaat aagaatgttt cagatgagat taatattata
     2161 aaagatgact atttaaattt agaagttgaa atcaacaact taaactctca agaaaaaaat
     2221 ctatcttatg aattagaaaa aatttcaagt gaaattgaga agttacaaca agaacaatta
     2281 aaaataaaga aagaattcag gaaaaaaggt ggaattttag cagaagaaag agaaatgctt
     2341 aattctagaa ttgctgaatt agaaggaaat agatttataa ttaatcaaaa tataaaagat
     2401 ttttgtaatg acatacttcc ctttttaatt gtaaaaaaac aaatattaaa cttagaaaaa
     2461 caacttaaag tagagaatga tagtatatta tattctcatc ttaaagataa attaaatatt
     2521 gagtatataa aaaatctact ttcagataag atcatgtctt cctcattaga tgaaatagct
     2581 ctaactgttt ctgaggcttt aatagaagat ataaaaccag atagttatga agataacttt
     2641 gaatctatcc ataagctttc taatgatgaa agtagtaaat tattatcttt gataaatacc
     2701 attttaaatt ttgataataa ttctatcatt aattcctttg gagaacatcg aagtatttca
     2761 aatgaattgg cagacataag acataagtta aatactagct ttaaagatga aactttgaat
     2821 acatatataa atgatatatc tagtttatca gataaaattg attctttatt aaaatcaaag
     2881 aatttgctag ttacttcttt agataaatta agacttgaaa tagctgaaac tatcactaaa
     2941 agagacaaat ctaaggctaa atatatatat ttacttcaac ataataatat tgttgatata
     3001 tcttctaatc ttatacttat gttagatgaa ataataacaa cattaacaga aactaaaatt
     3061 aaactagttc aagataattt tatgtatata tttaaaagga ttattcaaaa agacaatttt
     3121 attagttcta tagatattga tgccaacttt aatatttctt tatatataaa taaaatatat
     3181 aactctttag aacttgaaaa tttagtagaa aatataggat ctgaagaaat ggagaagaag
     3241 ttgggaaaat tattttttga ggatttattt aacttatatc gtgtaaaaga taaagatgat
     3301 ctattcaatg ctataaaaaa taatactcaa tctacatttt taaatctaag aactaaagtt
     3361 gacatagacg aattctctag tggtgaaaaa caaatataca ttctttgttt atattgggct
     3421 ttacttaaat cttcagagat agaaatacca tttattatag atacacctta tgctagaata
     3481 gatgatactc atagaaataa tattactagt gaatattttt ctacaataag tgatcaagct
     3541 ataatactat ctactaatac tgaaatagat gagaaatcat ataagataat aaagcctaag
     3601 ttaagtaatg aatacttgat tgaatatgat aataaaaata aaaaaactat acaaaataaa
     3661 ggatactttt tcgaggtgta attatgggat ttagacttaa aacatccata caaacaaaag
     3721 aaatatttga agaattagga tctagaatga atttgaaacc atttgctctt tgcaaactag
     3781 ctatctcaat ctcactaagt aatagtgagc caattgaaaa ctatgaaagc atcgataata
     3841 atggtcttga acttaataga caaactataa ccaatcaata tgatactcta tttaaaactt
     3901 tacttgaaca gcatgcaggt agacatttaa gtgatgatga atactttcct aaccaagtta
     3961 agcttcatat agatagaggt gctcttatgc ttaaaaacag atataattat tcaagcaact
     4021 tagaacactt tatcactcaa atagtacagg aaaataataa tctataaatt aattaatatt
     4081 tattaaacat aaataaatta aaacatggga tagacaataa ataaaattgc ctatcccatg
     4141 ttttaattat aagtattttt tctaaattca tttattttat ttattaagtt cccaaaatgc
     4201 tttatctcta atatatatag gtgagttctc actaggcatt ttgactaagc tttcatgttt
     4261 agctagattc tttatcttat tatatatgtt atcttcttca cttttattct tagaattgaa
     4321 tatgtatctt atgtctttat tatttatgtc tgatacatta tgtattatcc aagttgaaat
     4381 ataattctga tactcatttt ctgaagttga aaaatgactt agaagttgtg ttgatagaat
     4441 agttcctact ccaaactctc taccttcctt caatatattt tttatagatg taaagtttct
     4501 actcaagaaa ttatcagctt cgtctactaa tatcatttta tttaattgtc tatactctcc
     4561 atttccagtt atatcacttg atccaagtgc cttcatttga ctatagaata aatcaagagt
     4621 tatcgcaact actaaatttt gtattcctga atcataatat gataaattta taactgtaac
     4681 tccatttatt aaatcaaata aatttttagt cttctcacta tttggctcaa atatttcaaa
     4741 atcattaaaa cttgaaagag cagcatacaa tttatcgtct ttttttattt ctcgatcatc
     4801 aaggtatatc gataatacat cttgcattgt agggcatgat tttacccatg tattttcatc
     4861 atcttttttt attccttttt tttcataagc tttcataatt aattctctca aaataacttc
     4921 ttgcttaggg cctaagccaa atgcttttgc tattgtctct tttaaagaat tcgctgtgtg
     4981 aacaggtagt agtggcttta ttctttcagg tattattaaa gttaatggat tataaggtaa
     5041 atgatatatt tcatatacct tagcacttgt cgcatctaca aaatcatctt ttatgtagtc
     5101 gcctttataa tcaaaaatca gtattcctat tggtttacca tttatgttat gtttttgttc
     5161 tctatgaatt tgcgttacta aagatttagt aaactgtgtt ttcccagttc ccattgttcc
     5221 tattatacca gtattaggat gaggcacttt aatcgaattt gttggatccc aaataagttc
     5281 tttattatta ttttttatat ttccaaatat aattttcatt aaaccacttc aatcataatc
     5341 ttttgtttta tttagcataa cattagtatc taaaataaca ttcttatcca tattttgtat
     5401 acctattgta ttatctaaat acttatttat aagcatttct tgtataacaa aatcactctc
     5461 tcctctaata tacttctcct tcatttcctc taaatccatc actatattat tatatccttc
     5521 ttgttctgaa agatttagta tagttatatt gccttctttg cctaaattcc cattataata
     5581 agttcccttt ttaaatgata ttacagctcc tcttcctata aattcatcta aatcattact
     5641 tatttcataa ttatcattca acaagtttgt tcttatatca ctatttatta tatcatccca
     5701 attttgttca tcccatatat gatataactt cattttttgt gcacttacta tagcgagttg
     5761 tatcataaaa ttcctgtaca taagctttgt aaacttttgg gaatcatttt cgctttcagt
     5821 caagtactct tctattaaat ctcttgtctt attagcctga attattgcct tttttatgac
     5881 actttcatta ttatctccaa ttttcacttc aacaggataa aaatatactt ttattttatt
     5941 atttttattt tctatcccaa caagtaataa atcatctgaa taagatccag tatctcctgt
     6001 tagtttctta acagtaaaca aaccacctgc ttgttttaat ccagctccac cagatactct
     6061 aagtatttct tcaagagata ttggtatcca tattatattt ggatgataaa aataagctaa
     6121 gcttattttt atagctgata atatgcttaa tttttctcta ggaaactgag atttactaga
     6181 tataagcctt aataaccaat ctccatttat agcattgaaa taattaatca aattagggat
     6241 tgtgtcttct tccactttaa tatctttact atttagaaat tcttcaatta taaatttata
     6301 ttgttcagat tttctagtaa ctgttatagc atcatatcca ctagatgttg tatattgatc
     6361 actataatgt attattaata agtcatttga attctcatca tccttaaaaa aatttaaatc
     6421 cacttttgga tctataaaag taacccaatg agatgtctta taaattttat ttaaaaatga
     6481 actattgttt tcacttattg atgttgtcac actaagatta tcattaaatg gatctccagt
     6541 tcctattgat tttgtaagtg aattaaactt cattgaaata tttaacagtt catttttagt
     6601 tgtagccata aacttagatc caaatccagt cctataagta tcctctaaat atattgatgg
     6661 aactcctgct atcaatccat ttaatgctac acctgttttt atatcatcca tagagctact
     6721 tgttatattt acatccttat ccatttgata taaagtcaaa tgggaatact catataaatc
     6781 tgacatttta tcttttttat aaaatttaac tttatctcta aataaattta atacatcttc
     6841 ttcagagtaa ttgtctacac ttaaatttac attaaaatgt ttttttatat catttattga
     6901 attataaaat gctatttctt caaatgaatt tataatactt ttatctccat atatataaat
     6961 atctattgat attaagttat ttatttcctc acctttacct aatttcttta tgtaataatc
     7021 aaatatacca agtaatactt ctttacaatc acctaaattt attagcttta tcttcattac
     7081 tgatttactt atatccctaa ataaatatgt aaaatgttct ataaattcat ttattttttc
     7141 ctttgtcaat ttagagacat aatctctaga tcccttatat ctactcatgt catgatcaac
     7201 atagtatgtc cactctggtg aatgtctttg atctactacc ttatataaac tattcttacc
     7261 tttatatata tagggcatta gatacttcga acccaatagt tttaagattc cttctttaac
     7321 ttcttcatca cctataacat tatttatcat taattggtaa gccacattta ctggatgtaa
     7381 tggtgttaaa aataattctt cttctttatc tattctatgt atagtcccta ccttagctat
     7441 attaagtctc tctttagata atacttttcc attttttata tcttcaaaca cttctaatat
     7501 agtatttata taattttttg atatgttaac taaatccaca tcataatatg ccaagcttgg
     7561 aatacaatca tttactttat agtaacttat aaggtttttg tatgcttctt ttattctgga
     7621 atctacatcc aattctatta ttttatattt ttcttctaaa atagtacaat gcattatatt
     7681 attttctatg atatattttt ctatttgcaa attttcttta aaattttctt ttggaaaata
     7741 ttcactagta ccttgtacaa ttttactatt acctaaatat ttaaaactct cctttcgttc
     7801 tctctttaat ttccaggttt tcattccact tatagaaatt ggttgttctt tttcttcttg
     7861 tttaactatg gtaattacag attgatcata tactacatca atttttataa attcaacatc
     7921 ttcttccaat tcaacattaa gttctaaatc tagcctttct ccttcttcaa gattaatttc
     7981 attttcaaac tcatctattt gtatttttct ctcaattata ccttttgggt ttattactat
     8041 tgtatcatca tctgtgttag taactaacat acttcttttt gaattaataa caattccata
     8101 attacttttt atatcattta atatattctc atcacaagat actatacaaa ttctaaattc
     8161 atattttatt ataccatcat tatatttaac tttagtaaat gtagtttctg aaatatttat
     8221 atttatactt atataagctt tatttccact tgcttttact tctgtatatg ttttagacat
     8281 cttatctata gaaaaacttg ttttttcaat tttcttatca aattttatgc ataaatttat
     8341 aatatcaagt ttgtctttat taaataataa tatgtttttt cgttttgact tattttcaat
     8401 atctggttta ctccagagct ttaggttttc aacacattct atacataata actctacctt
     8461 tttgtttttc attctttctt gagatgactt tatatcttta taggtagaat acttccaatt
     8521 ctcatctttt aaaagatcta taccttttga atcaaaatgt ttctctaatt ccagcttagg
     8581 gtctccatac tgatgtatag agtttacaat agaaaacagc ttttcattat ctaatagtct
     8641 ttcttttatt gccttgctac ttttgttgtc taacatatta tcatcataaa ataatccaaa
     8701 tttactatat tcactctttt caattcttcc tttatttaat atatctaata tattttcata
     8761 ttgaaatatt gatgaattat cttctaatat acttttattc attctatcaa gtacaaaata
     8821 aagtatatgt ttaatatctt cttttaattt atcattttct aatttatttt gtatgtcctt
     8881 tactaaagtt tttgtatgaa atggcatacc ttctttttgc aaactttctg ttcctcttat
     8941 taaactatct aatgtcatat tatgtataaa taatatggct gaatccttaa attcatcact
     9001 agctacattt cctataagat ttctaagtct aattaaaaaa tcattggttg tattattatt
     9061 tgaagcaact attaattgaa taccactgac attcatacta aaagtctgat attttgatcc
     9121 attcattata ttatatgtaa atggtctact attactttct ttctctaaaa catcatacat
     9181 aattttaact tgttcttctc tttcaaactg tatattaaat ttatcgccac tttttatttc
     9241 tctagattcg aaatatttaa ctagattttt agctagatat ctataaaatt gatctgacat
     9301 attgtgcatc cccactatca ctcttttttt ctattatatt taatttttca aataactcta
     9361 ctactttgct ttgagaatct ctatcaaaat aaattcctct tttttcatat tcttcaaata
     9421 attcctttaa ttttatcttt gtcttatttt tcatacataa ttttgtcata aataacagtt
     9481 cttcttgatt aattttcaat acatttccca atggccctgc tttttttaaa aaatttaatt
     9541 tacaatactc ttcaaataaa tttttatacc tcttatagtt agcctctctt gaagatttct
     9601 tgaactgata atctattctt ttatgtaaat cacatatttc ttcttttatg ttatcattct
     9661 tatacacttt agtttgttca tcataatcat cccattgtac atcagtaatt gacttgacat
     9721 aagtattttt tatatctatt atattttcat ataacctaag tctttcattt tctgataaat
     9781 tttttataat tttatttaaa tctacataat catacttact aatgtcatta ttagtattta
     9841 atatctctaa tgtatgaaca tgactaaata atattctaat atgactctcc aacattttcc
     9901 aacccatgtt ataacttatt cttgttttag atgctttttc ccaacttaaa ataaaatata
     9961 ctttttcagt tctatctcta tctccatcaa aaaagtgaga taattttatt gataattgtg
    10021 atacatagaa aaaataatag tactttaata atctttcaaa ctcgtttata attaattctg
    10081 gataattaag cataaattct aaatcttctt ggaataattt agacacattt ttacatatac
    10141 atttataaat tgatttagac gtctcttcat tttcaagttc aggaagattt tttaatataa
    10201 taagttccat aatattatca ggttcatatt caaaacattt atttatttta ttttttatag
    10261 ttatattatc tgtactattt agtaaaacat catataaaaa tttagacaat tttttataat
    10321 aactatcaga tggcatatgt atataattta aaagctttgg atgaaatata tacatatttt
    10381 cttcttcatc caaaaataat tctcttatta tactctcaag ttgtacacta tcatcagaag
    10441 aattcacatt tatgtctttt ataagtaact ttatatcttt tagctgtctt tcttttatgt
    10501 tcattttctt gttatatacc aacctacaga attctccaac acaagactca aatctttcta
    10561 ccttttcttt aagtttcgat ttttctttag ttgtagttgt atatgggagt ataactatgt
    10621 ttttgacact attatgtctc gcgatacctt tatctatcat ataattttgt ttaaagtatt
    10681 ctttatttat tataagttgc ataccttcac cccatttact cttataaatt tgaatttatc
    10741 aaattcttta tcatatgtta atttatattt aggcacagta tcttctaatc tatcctctat
    10801 atatagttct ctgttttgat ttcctaattt atgtatctta ttcataaata ctacaaaatt
    10861 tatgtaagta tatttatcat tattgtttgg tgtatatcca tattttactc tcattagtaa
    10921 cttatataaa ttaaaatcta tatccactgt acaagtatct tgattttctt tttcatcatt
    10981 tttataccct atctctaaac taggcttaaa cttgtgcaat tcttcctcag tacattttct
    11041 taatttgctt aaatctggaa ttatatttag cctttgactt attttatatc tcatctgatt
    11101 ttttccaatg gacatattta ttctgtcatc ttgaatacgt ccattccaac tatacaaagc
    11161 ttctttaata tcatcatata aattacttaa ataagttttt tctcctttgt taaaatagta
    11221 taaatttctc atgtaactta tatatatatt atctcttaac tgtaaattat ttttaggtat
    11281 aaatatatgt agtcttataa atgtatttat tatattgtat tttaatattt tcctactcag
    11341 ttcgttcttt gaagaattca aagccgactc tattatttct ctatttgtca tagaactttc
    11401 tagataactg tttttactta aattcaggta ttgattaaat agtattgtca tatcttttgt
    11461 attactaagc ttaatgatta tattatctag gttttctgat gtgatattta tagggtcaat
    11521 tttatttact gcatttaaaa tctgagataa ttcactatga ttatataaat tagatacaaa
    11581 tatatatttt atgaatgctt cataacttag ttcttctaca aacttaatta agtctttatt
    11641 atttttattg tctaaatcaa cattaacaat aaaatcatat ataaaattca aaagagacct
    11701 tgttgaaatt ataattttat atttaactgt agattctatc aatatatcca ccaaggtttc
    11761 tctcactgag tctctcatta acatttcata attattttta atcggacatt tataattgac
    11821 aatacaatgt gtacaatttg ttttataact atttataaat atattttgat tatcttctgc
    11881 tattatttta ttaattatag attctatata tctagattta ggtttatctg cattcaaagt
    11941 atatatatga taatcactaa aattaacaaa atgaaaattc gaatttttat catcatcatc
    12001 tgatatagat atatcaagta ttcctttatt ttcaacaaac tctcttaatt tagtaaattt
    12061 attaacatat tctgattcaa gaaaattact aagtgcccct aaatttattg ctaatactaa
    12121 ctttttatct gaattatcca ttttcttatc tgaaaaatca tcaagtacat cattaagtgt
    12181 atctattgat gttttatttg gttcaaaact ttctgtagca tcattatgaa ttataaattt
    12241 tgacataatt tctggatatt tgttatttaa atatgatatt aaatgcgatt ttccatctcc
    12301 tactccacca cataccaata tcaactcagc tttattagaa tcagctgtat attttataat
    12361 atcaagtaat tcgttttcta cttgtctttt aacatgcata tattttttaa aactactaaa
    12421 atctgaaata ttttctactg cttcctttga tgattctttt aatttcttta attcatctat
    12481 caaacaacca tttgacataa ttttaaaact ccttctaata tactctttta tactacactt
    12541 atattataaa tgctatttat ttctttgaga tccctttatg taaaaaaaac catta
//
LOCUS       DAEQCW010000106        12552 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.107, whole genome shotgun sequence.
ACCESSION   DAEQCW010000106 DAEQCW010000000
VERSION     DAEQCW010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12552)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12552)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12552
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.107"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(55..915)
                     /locus_tag="KRO40_002934"
     CDS             complement(55..915)
                     /locus_tag="KRO40_002934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBH2093744.1"
                     /translation="MLLKKDRITFSEILILIVGCILMAISLNLFFNPHAIAAGGITGL
                     GVVLNSLFGVELWIVNLLLNVPLFIFAYKILSKKDCFKTVLGIIFLTIALKLTANMAT
                     LDITNDMYLAIISGSILMGVGQGLIFRINGSTGGTDLMALLLNKYFPTFSIPVLMGIV
                     DCVVVVLSGIVNRQVEIALYSTVALYILVKVSDLLIEGFNYSKSFTIISDLSKDISKK
                     IMEDLDRGATILKGEGAYTGENKNVLLVVVEKKEVVELKKLVKNVDPNAFIIITDIHE
                     ALGNGFKKIE"
     gene            1064..1954
                     /locus_tag="KRO40_002935"
     CDS             1064..1954
                     /locus_tag="KRO40_002935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2093745.1"
                     /translation="MAKLTLEHIKGNTYYIPLPTIVGVYVDGKDAILIDSGNNKDTAR
                     QVLRLLEEHNLNPKLIINTHSNADHIGGNAYLKNQTKCKIATTKIEGYFTENPILESA
                     FLYGGYPSKALKNKFLLAKESEVDYIIPSNGKIVDTELEAISLPGHYFEMIGVRTPDN
                     VLFVADSLTPENIITKYHFFFLLDIDSQFKTLEKLRMLEADFFVPSHSVKTTDIKSLI
                     NINKKKMEEIIDNIKKVCYEPVMIDEVIEKMCDLYNVKLDANQYVLVGSTIRSYITYL
                     YENNMVEYIFDGGKMMIKAA"
     gene            2172..3926
                     /locus_tag="KRO40_002936"
     CDS             2172..3926
                     /locus_tag="KRO40_002936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp23"
                     /protein_id="HBH2093746.1"
                     /translation="MYIMNKKFKKFSKKLSILILVLTMFLFNNLTANAQIKEDSIIGI
                     DRYETAGLIADRQTYDTVILVNGDKNLSDGLSSSGLAGAINAPILLTKKSEIPKATLN
                     RLDNKSLNVVKKVYIIGGYNTIENSVEKDIKRKGIQVERINGNNRIETSYNVAKKINE
                     VSSVKEVMLTNGFVGEADAMSIAPVVAKNKGAIILTDGKSVPFKTEGLNVYAIGGKSA
                     INEDLVNETKAIRIGGNDRFETNKKVMEKFYNGATDFYITNGYQLVDALTLSPLAKEK
                     PIVLVADGSNKGILKGAKSITKVGGIDANIYKQCLDMIKYNNMDMTPNILKHLTSVEG
                     NEVSEILIESDNLGVVVEKTNTNKFEFDYVSVTNEKNCTFSVYKENSSNNIKNGKLVV
                     SAKKKIDKKDSDLQDMNGDNMINANKDRMVNVIKIGVPDKMYSNFKVDVESGSVELYN
                     IKGGATVDVNDGIANIVDNNVTNPFNINTNSGISGVTAETISSEIKFRANNGIVNVTA
                     TNINGNISLFGSDNKDTFDGIFKLNLKKEPSNLHLKLIGNGINKLPEGWSKDYILGNG
                     QPIIEVKNNGINNISIGE"
     gene            4310..5296
                     /locus_tag="KRO40_002937"
     CDS             4310..5296
                     /locus_tag="KRO40_002937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBH2093747.1"
                     /translation="MKKITINDIANLAGVSKSTVSRYLNNKDISDSTKEKIKTIIDEY
                     GYEPNAFAQSLRAKKTYFIGIITPCLDSFVKSKIMMAIDEELKKLKYTSLIINTNRKI
                     RSEIDSISKLASLKVDGIILIGTEITKEHKNEIEKLDIPIVVVGQKVDGINSIVNDDY
                     GAGYKMGQYIANKGYKNIVYLGVDESDISVGLNRKNGVLNGLKDKGYDAKVFYTDFDQ
                     EMSIQRSGEMLESENPDIIICATDNIAIATMKEINKRGKSIPQDISVAGFGGYDVLSI
                     ISPKLTTIKFENKNAGKVAANTIVNLIQERKEPLLKEIKFELIEGESTINKN"
     gene            5465..5613
                     /locus_tag="KRO40_002938"
                     /pseudo
     CDS             5465..5613
                     /locus_tag="KRO40_002938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423822.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIB"
     gene            5632..7113
                     /locus_tag="KRO40_002939"
     CDS             5632..7113
                     /locus_tag="KRO40_002939"
                     /EC_number="3.2.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="HBH2093748.1"
                     /translation="MYKEPKYRTILESTKEELNKLRNISLNDKYKPLFHIHPQHGLLN
                     DPNGLAYYNGKYHVFYQWYPYDATHGMKHWAYVSSDDFVNWNREDVALIPIESYESHG
                     AYSGNAIEVDGKLHMYYTGNIKYSAEDRYAYQNLAIMNKDGKITKYENNPIVSEIPKG
                     YTGHVRDPKVFKRKDKYFMLLGAQTSDKKGVIIVYESKNSIDWNFKGELNVKNIDEDF
                     GYMWECPDYINIDEKDILIFSPQGVEPKGFDYQNIYNVVYAIGNMDLDNLTFEIDTMK
                     ELEKGFDFYAPQTFIKDSQIILFAWAGMGEVLYPTDKNKWAHCLTVPRKLNIKNNKLL
                     QMPVDELIKLRYDETSGQNTIKNNINIIENDENVYELNINIKNIDSNKFGLELFSSQD
                     EGVKLEFNKLGNIVTLDRSNFKKVFGVEYGTNRKEYINIDENTNIKVLADRSILEIFI
                     NEGEVVFTSRIFAKENSNQIRVYSDKIVEYEYTKFKLKQGIEL"
     gene            7139..8110
                     /locus_tag="KRO40_002940"
     CDS             7139..8110
                     /locus_tag="KRO40_002940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate kinase"
                     /protein_id="HBH2093749.1"
                     /translation="MKKVISIGEALIDFIPNQNGGKLKNVSEFRRVAGGAPANVSAVV
                     AKLGGKSSFISKLGKDAFGDYIIDVLNEVNVNTDYVLRTSKANTGLAFVSLKEDGNRD
                     FSFYRNPSADMLLEADEVKKEWFNNCHILHFCSVDLIDSPMKLAHKKAIEYALESNSI
                     ISFDPNIRLPLWDSEQSCKKAISEFLPFAHIVKISDEELEFITGENDIEKSLHKLFVG
                     NVELVLYTKGKDGVDAYTKKVKGMCKGVKVNAIDTTGAGDSYIGSFLYTLLYKQITLN
                     DIKEMKQETLNEYLEFSNYYAARSTTIKGAISSYATKEEITEFIKNL"
     gene            complement(8366..8968)
                     /locus_tag="KRO40_002941"
     CDS             complement(8366..8968)
                     /locus_tag="KRO40_002941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2093750.1"
                     /translation="MEVCILMGSPKKKGNTAAILKPFIEELENYNSNIEVIWLYDCKI
                     EPCIACKKCQDNLFDFGCYCKDDVQKIFKKILMCDLIVFATPIYSWYCTSPMKALLDR
                     LVYGMNKYYGNEKGPALWAGKSVALITTCGYRPEKGADIWENGMKRYCKHSQLKYIGM
                     LVERDLGKPNFMNKEKEEHSRQFAKQIYYILSNSIELDNC"
     gene            9249..10460
                     /locus_tag="KRO40_002942"
     CDS             9249..10460
                     /locus_tag="KRO40_002942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HBH2093751.1"
                     /translation="MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSI
                     KTNPYNKIVKSIAEQGFGADASSTNEVMISSKCGVSKDDIYYSSPGKTEIDIETVLDK
                     CIIIADSITEIELINKISKKHNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
                     KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSG
                     LGVAYDNLRENPLNLKELSKLTQKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVD
                     IKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLYTSNHAFSLSVLNNL
                     KEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPK
                     QYYKRKDGYIE"
     gene            10528..10725
                     /locus_tag="KRO40_002943"
     CDS             10528..10725
                     /locus_tag="KRO40_002943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug transporter"
                     /protein_id="HBH2093752.1"
                     /translation="MELWKRNLFVCWIGMFFSSIGMSQIAPILPLYIKQLGVTDVSLI
                     QQYSGIIFGCTFVVAAFFSPI"
     gene            10759..11730
                     /locus_tag="KRO40_002944"
     CDS             10759..11730
                     /locus_tag="KRO40_002944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093753.1"
                     /translation="MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTT
                     LIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFI
                     ISILFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI
                     YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIF
                     IPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGC
                     SSGAFLGGQISAHLGIRTVFFSTSLLLFRNALWMYKFTGLFIKDKTK"
     gene            11917..12294
                     /locus_tag="KRO40_002945"
     CDS             11917..12294
                     /locus_tag="KRO40_002945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093754.1"
                     /translation="MTISKIPQAELKVMKFIWEKNDTVTSKETIEAMERKYGWKQTTT
                     LTLLSRLVKKHFLSAEKIDRYTHYTIVVGHKEYLSVETKDFLSNIHDNSLQSLISALH
                     DDEVVDKDMLDLFESHFKNLEEE"
BASE COUNT         5109 a         1311 c         1996 g         4136 t
ORIGIN      
        1 catataaaaa gttgaatttg tatatgttaa ttatacttgc tatttatttg ttagttattc
       61 tattttttta aatccattac ctaaagcttc atgtatatct gtaattataa taaaagcatt
      121 agggtcgaca ttttttacta attttttcaa ttcgacaact tctttctttt caactactac
      181 taaaagtaca tttttatttt ctccagtata tgcaccttct ccttttagaa tagttgcacc
      241 tctatctaaa tcttccatta tttttttact tatatctttt gaaaggtcag atataatagt
      301 gaatgatttg gaataattaa atccttcaat aagcaagtca ctaactttta ctaaaatgta
      361 taaagccaca gttgaataaa gtgcaatttc aacctgtcta tttactatac ctgataaaac
      421 aactacaacg cagtctacaa tacccattaa aacaggtata ctaaatgtag gaaaatattt
      481 atttagtagg agtgccatta aatcagttcc acctgtagag ccatttattc taaaaataag
      541 tccttgacca actcccatta aaatagaacc agatataatt gcaagataca tatcatttgt
      601 tatatctaat gtagccatat ttgcagtaag cttaagtgct atggtaagaa aaattattcc
      661 taaaaccgtt ttaaaacaat ctttttttga aagtattttg taagcaaata tgaataatgg
      721 aacatttaaa agtaaattga caatccaaag ttctacaccg aataatgaat ttaaaacaac
      781 tccaagtcct gttataccac cagcagcgat tgcatgtgga ttaaaaaata agttaagaga
      841 aatggccatt aatatacagc ctacaattaa tattaaaatt tctgaaaaag ttattctatc
      901 ttttttcaat aacatcactc cttatatata gattataata tatattatat agtttttcca
      961 atttttaata aaagaaataa aaatatatta taaaaacaat ttgattggaa ttttcagaaa
     1021 attaatgcta taattaaaag taaatttaaa gggaggttat aaaatggcta aattaactct
     1081 agaacatata aaaggaaata catattatat tccactccct acaatagtag gtgtatacgt
     1141 agatggtaag gatgcaattt taattgacag tggaaataat aaggatacag ctagacaagt
     1201 tttaagatta ttagaagaac ataatttaaa tcctaaatta ataataaaca ctcattcaaa
     1261 tgcagaccat ataggaggaa atgcatattt gaagaatcaa acaaaatgca agattgctac
     1321 gactaaaatt gaaggatatt ttacagaaaa tccaatatta gaatcagcat ttttatatgg
     1381 tggctatcca agtaaagcac tgaagaataa atttttatta gcaaaggaaa gtgaagttga
     1441 ttatattata ccttcaaatg gcaaaattgt agatacagaa cttgaagcga tttctcttcc
     1501 aggtcattat tttgaaatga ttggtgttag aactccagat aatgttttgt ttgttgcaga
     1561 tagtcttaca ccagagaata taattactaa atatcatttt ttcttcctac tggatataga
     1621 ttcacagttt aagacactag aaaaattgag aatgttagag gctgatttct ttgttccaag
     1681 tcactctgtc aaaactacag atataaaaag tttaattaat attaataaga agaagatgga
     1741 agaaataata gataatatta aaaaggtttg ttatgagcca gttatgattg atgaagttat
     1801 tgaaaaaatg tgtgatttgt acaatgtcaa gcttgatgct aatcaatatg tgttggttgg
     1861 aagtacaata cgttcttata taacttattt atatgagaat aatatggttg aatatatatt
     1921 tgatggtggt aagatgatga taaaagctgc gtaaatagta ataattttca aattatatga
     1981 tgaaattgtt ttagtatgac tgttatttga aaagtaatat aaaaaaattt atataaataa
     2041 gctaagatga ttgatataaa gttactgata attttaaggt aatatatacg ttactataat
     2101 attatgttat tatttgtaaa taaggggata atttataagc aaattaaaga ccttaattta
     2161 caggaggaat agtgtatatt atgaataaaa aattcaaaaa attcagtaaa aaactaagta
     2221 tattaatttt agttttgact atgtttcttt ttaataattt aactgcaaat gcacagatta
     2281 aagaagattc aataatagga attgatagat atgaaacagc aggacttata gcggatagac
     2341 aaacttatga tactgtaata ttagttaatg gagataaaaa tttatctgat gggctttcat
     2401 caagtggatt agctggagct attaacgcac caatactttt gactaaaaaa agtgaaatac
     2461 caaaagctac tttaaataga ctagataata agagtttaaa tgttgtaaaa aaagtatata
     2521 taattggtgg ttataatact attgaaaatt cagtagaaaa agatataaaa agaaaaggta
     2581 ttcaagtgga aagaataaat ggtaacaata gaattgaaac tagttataat gtagctaaaa
     2641 aaataaatga agtaagtagt gtaaaagagg taatgcttac aaatggattt gtaggagagg
     2701 ctgatgctat gagtatagca cctgtagttg caaaaaataa aggagctata atacttacag
     2761 atgggaaatc agttccattt aagactgaag gtttaaatgt ttacgctata ggtggcaaat
     2821 ctgcgataaa tgaggattta gtaaatgaaa ctaaagcaat tagaatcgga ggaaatgata
     2881 gatttgagac caataaaaag gtaatggaaa agttttataa tggagctaca gatttttata
     2941 taacaaatgg atatcaatta gtagatgcac taacattatc tcctttagcc aaagaaaaac
     3001 caatcgtttt agttgctgat ggaagtaata aaggtatttt aaaaggagct aaaagtataa
     3061 caaaagttgg aggtattgat gccaatatat ataaacagtg tttagatatg attaaatata
     3121 ataatatgga tatgactcca aatattttaa aacacttaac ttcagttgaa ggaaatgaag
     3181 tttctgaaat acttatagaa tcagataatt taggtgtggt tgttgaaaag acgaatacca
     3241 ataaatttga gtttgattac gtaagtgtaa ctaatgaaaa aaattgtact ttttctgtat
     3301 ataaagaaaa ttcttctaat aatataaaaa atggaaagct agttgtaagt gctaagaaaa
     3361 aaatagataa gaaagatagt gatttgcaag atatgaatgg cgacaatatg ataaatgcaa
     3421 ataaagatag gatggtaaat gtgataaaaa ttggagttcc cgataaaatg tattctaatt
     3481 ttaaagtaga tgttgaaagt ggttcagtag aactttataa tattaaagga ggagctactg
     3541 ttgatgtcaa tgacggaatt gctaacattg ttgataacaa tgtaacaaat cctttcaata
     3601 taaatactaa tagtgggatt tcaggtgtaa cagctgaaac tatatcatct gaaataaaat
     3661 ttagagcaaa caatggaatt gtaaatgtaa cagctacaaa tataaatggc aatataagtt
     3721 tatttggaag cgataataaa gatacttttg atggaatatt taaattaaat ctgaaaaaag
     3781 aaccatcaaa tttacacttg aagttaattg gaaatgggat aaataaattg ccagaaggtt
     3841 ggtctaaaga ttatatttta ggaaatggac aaccaattat tgaagttaaa aataatggca
     3901 taaataatat atcaattgga gaataaaaac atatgaaaat aaagtttata tagttttaaa
     3961 aattatagaa ttttaaaata tttatatata ttctttaaat aaaaaattat tttttaagtg
     4021 ataattaagt gtttatcgat aaggctatgg ttgtaaaaat catagcctta tttttatatt
     4081 ataaataaat tagagtattt atcaattcat agtagataaa attgaaatta aatataacaa
     4141 caaaaaatga aaattacaat taatttaatg ttaaagactc aattatttgg atgtggaatg
     4201 gatagtacaa gtagtatata aaaagtattg actggacaaa taactatatt ttattttaaa
     4261 tatataatat aatgtaataa aatatatcaa atgtagaagg tgataaccta tgaaaaaaat
     4321 aacaataaat gatattgcta acttggcagg agtatctaaa agtactgtat caagatatct
     4381 aaacaataaa gatatcagtg attctactaa agagaaaata aagacaataa tagatgaata
     4441 tggatatgag ccgaatgcat ttgctcaaag tttgagagct aaaaaaacat attttattgg
     4501 tattataaca ccgtgtttag attcttttgt aaaatctaaa attatgatgg caatagatga
     4561 agaactcaaa aaattaaaat atacatcact aattattaat actaatagaa aaataaggtc
     4621 agaaatagat agtatatcaa agttagctag tctaaaagtt gatggaataa tactaattgg
     4681 taccgaaata actaaagaac ataagaatga aattgaaaag ttagatatac cgatagttgt
     4741 agttggacaa aaagttgatg gtatcaatag catagtgaat gatgattatg gagcaggcta
     4801 taaaatgggt caatatattg ctaataaagg ttacaaaaac attgtatatt taggtgttga
     4861 tgaaagtgat atatcagttg gtttaaatag aaaaaatgga gtacttaatg ggttaaaaga
     4921 taaagggtat gatgcaaaag tattttatac tgactttgac caagaaatgt ctatacaaag
     4981 aagtggagaa atgctagaaa gtgaaaatcc agatataata atatgtgcaa ctgataatat
     5041 agcaatagca acaatgaaag aaatcaataa gagaggtaaa agtataccac aagatatatc
     5101 tgtagctgga tttgggggat atgatgtatt gtctattata agccctaaac ttacaacaat
     5161 aaagtttgaa aataaaaatg caggtaaagt agcagcaaat acgatagtaa atttaataca
     5221 agaaagaaaa gaaccactat taaaggagat taaatttgaa ttaatagaag gtgaaagtac
     5281 aataaataaa aattaagata cacattacat atattagtaa tgtgtatttt tttactaaaa
     5341 aaactataat tctaaaaatt aggaaaactt ttttgaaaga aatattgcat ctgaaataaa
     5401 tttatgctaa tctttaatta aaccggtttc gaaaccggtt taattaaacc gatagaatag
     5461 caaaatgagt gcaaaaataa ctgattgtaa caaagtatca aagtaattat tggagtacat
     5521 aggaataaac aaaatataaa agatgtagca cattgtgtaa taagactaag aattgtttta
     5581 gatagcaata ataaagcaaa tataaaatta taaaagaaaa ggaataaaaa tatgtacaaa
     5641 gagcctaaat atagaaccat attagaatcg acaaaagaag aattaaataa attaagaaat
     5701 atatctttaa atgataaata taaaccacta tttcatatac atccacaaca tggactactt
     5761 aatgacccaa atggattagc atattataat ggtaagtacc atgtatttta tcaatggtat
     5821 ccatatgatg caactcatgg aatgaagcat tgggcttatg taagttctga tgattttgta
     5881 aactggaata gagaagatgt agcattaata ccaatcgaaa gttatgaatc tcatggagca
     5941 tattcaggta atgcgataga ggtagatgga aaattgcata tgtattatac agggaatata
     6001 aaatatagtg cagaagatag atatgcatat caaaacttag ctataatgaa caaggatggt
     6061 aaaataacta aatatgaaaa taatccaata gtaagtgaaa taccaaaagg atatacagga
     6121 catgtaagag acccaaaagt atttaaaaga aaggataaat actttatgtt acttggagca
     6181 caaacaagtg ataaaaaagg agttataata gtatatgaat ctaaaaactc tatagattgg
     6241 aattttaaag gagaattaaa tgtaaaaaac atagatgaag attttggtta catgtgggaa
     6301 tgtccagatt atattaatat agatgaaaaa gatatattaa tattttcacc acaaggagta
     6361 gaacctaaag gatttgatta tcaaaatata tataatgtag tatatgctat tggtaatatg
     6421 gatttagata atttaacatt tgaaatagat acaatgaaag aactggaaaa aggatttgat
     6481 ttctatgctc cacaaacatt tataaaggac tcacaaataa tactatttgc atgggctgga
     6541 atgggagaag ttttataccc tacagataaa aacaaatggg cacattgtct aactgttcca
     6601 agaaaattaa atataaaaaa taataagcta ttgcaaatgc cagtagatga attaattaaa
     6661 ttaagatatg atgaaacaag tgggcaaaat actataaaga ataatattaa tattatagaa
     6721 aatgatgaaa atgtatatga gcttaatatt aatataaaaa atattgacag caataaattt
     6781 gggctggaat tattttcatc acaagatgaa ggtgtaaaat tagaatttaa caaattagga
     6841 aacattgtaa ctttagacag aagcaacttt aaaaaagttt tcggtgttga atatggaaca
     6901 aatagaaaag aatatataaa tattgatgaa aatactaata tcaaagtact agcggataga
     6961 agtattttag aaatttttat aaatgaagga gaagtagtat ttactagtag aatatttgct
     7021 aaagaaaatt ctaatcaaat aagggtttat agtgataaaa tagtagagta tgagtatact
     7081 aaatttaaat taaagcaagg tattgaatta taaaaacaca ttataagggg tagaaaagat
     7141 gaaaaaagta attagtatag gagaagcttt aatagacttt atacctaatc aaaatggtgg
     7201 taaattaaaa aatgtatcag aatttagaag agtagcagga ggagctccag caaatgttag
     7261 tgctgttgta gcaaagcttg gaggaaaatc gagttttata tctaagttag gaaaagatgc
     7321 atttggtgat tatataatag atgtattaaa tgaagtaaat gtaaatactg attatgtatt
     7381 gagaacaagt aaagcaaata caggacttgc ttttgtatca ttaaaagaag atggtaatcg
     7441 tgatttctca ttttatagaa atccaagtgc agatatgctt ttagaagctg atgaagttaa
     7501 aaaagagtgg tttaataatt gtcatatcct acatttttgt tcagtagatt taatagatag
     7561 tccaatgaaa ttagcacata aaaaagcaat agaatacgca cttgaaagta atagtataat
     7621 aagctttgac cctaatataa gattaccttt atgggatagt gagcaatctt gtaaaaaggc
     7681 aatatcagaa tttttacctt ttgctcatat tgttaagata tctgatgaag aattagaatt
     7741 tataacagga gaaaatgata tagaaaaatc attacataaa ctctttgtgg ggaatgttga
     7801 actagtatta tatacaaaag gaaaagatgg agtagatgca tacactaaaa aagtaaaagg
     7861 tatgtgtaaa ggggttaaag taaatgcaat agatacaacc ggagcaggag attcttatat
     7921 aggttcattt ttatacacct tattgtataa acaaataaca ttgaatgata taaaagaaat
     7981 gaaacaagaa acgttaaatg agtatttaga attttctaat tattatgcag ctcgtagtac
     8041 aactattaaa ggtgcgataa gttcatatgc aacaaaggaa gaaataactg aatttataaa
     8101 aaatttatag taggaatgag taataggttt tgaaggaagt aacatgtaaa gagtttttaa
     8161 ggatgtttac tatgaaaata attaacatat aaaaagcaat aaggaggctg tctcaaaata
     8221 gagataagcc tctttatcat tgttgaaatg ataaaaaata ttttaattat tgttactttt
     8281 tagaagaata tatatcttat tttaaataag caaattatgt aagatttatt tatattatca
     8341 atactttact tggagtatta tgtctttagc agttatctaa ttcaattgaa ttagataaaa
     8401 tataataaat ttgttttgca aattgacgag aatgttcttc tttttcttta ttcataaaat
     8461 taggtttacc taaatcacgt tcaacaagca ttcctatata ttttaactgt gaatgcttac
     8521 agtagcgctt cataccattt tcccaaatat cagcaccctt ttcaggtcta tatccacatg
     8581 ttgtaataag tgctactgat tttcctgccc atagagcggg gcctttctca ttaccatagt
     8641 atttattcat tccatacacc aatctgtcaa gtagtgcttt cattggagaa gtgcagtacc
     8701 aagaataaat tggagtagca aaaacaatta aatcacacat aagaattttc ttgaaaattt
     8761 tctgaacatc atctttacaa taacatccaa aatcaaataa gttatcctga cactttttac
     8821 aagcaataca tggctctatt ttacaatcat ataaccatat tacttcaata tttgaattat
     8881 aattttctaa ttcctcaata aaaggtttta aaatagcagc agtattacct tttttcttag
     8941 gacttcccat aagaatgcat acttccatat tgatacctcc acagtatttt aaaatagttt
     9001 ttagtgctta atatagtttt aggatactat gagaatacgt taacaacaat acactttgta
     9061 tatttgtaat aaaattgaaa caaattgttt tatcaataaa agttggaatg tatctataat
     9121 taaaaatatt ttaggtatgt ttttacatat atgtgtgtag ttaactatgg taatttattg
     9181 taaaattatc ttataggatt ataattgctt aatttatgat tatatttaaa atcttggagg
     9241 taaaaaatat gtactcaaat gaagactata aatttataga agaaaatgca ccatgttata
     9301 tatatgatga gactaatata attgaaaaat gtaaggaatt gaaaaataat attttaggtt
     9361 ttgatttttt atattctata aaaacaaatc catataacaa aattgtaaaa agcattgcag
     9421 agcaaggttt tggagcagat gcttcttcaa ctaatgaagt tatgatttca tcaaaatgtg
     9481 gagtttctaa agatgatatt tattattcat caccaggcaa aacagagatt gatatagaaa
     9541 ctgttttaga taaatgcata attattgcag atagtattac agaaatagaa cttataaata
     9601 agatatctaa aaagcataat cagaaagtta aaataggaat aagaataaat cctgatttta
     9661 ctatggatga tgatagtgct aaatcaagca aatttggtat agatatagaa gatatgagca
     9721 gtgtttttaa gatgttaagt atgtgtgatt atgtatctgt agttgggatt catatacata
     9781 ttaaatctca ggtattggat tttgaaaagt taggacatta ttatgaaaaa tgttttttta
     9841 tagctttaaa tttaaataaa agtaagtata ttaatattga atttataaat tttggtagtg
     9901 gacttggagt agcttatgat aatcttagag aaaatccact taatcttaaa gagctttcaa
     9961 aattaactca aaagattgct tttactaatt caaacacact aaaatcaaga cttcttattg
    10021 aatcaggacg tttcatagtt tgtaaatcag gtaattatta tgttaaaatt gtagatatta
    10081 aagtatcaag agggaaaaaa tatcttattg taaaaaatgg acttaatgga tttatgagac
    10141 ctattatttc taatttaatt gaaaatatta cttgtggagt agaattagaa ggtcaagagc
    10201 cattatatac atcaaatcat gccttttctc tttcagtatt aaataattta aaagaagaag
    10261 agtatgtaaa tgttgttggg aatctctgta catcattaga tgtaattgca aataatgtta
    10321 aattgaaaaa agcaaacata ggagatttga tttcaattag taatgctgga agttactcct
    10381 attctttatc accgctatta ttttcaagtt atgaatttcc taaacaatat tataaaagaa
    10441 aagatggata tattgagtaa acaatagcat aaattaataa acttagtatt attgaaaaaa
    10501 tttaaaatgc agggggtgta attctatatg gaattgtgga aaagaaattt atttgtatgt
    10561 tggataggta tgttttttag ttctataggg atgagccaaa tagcacctat acttccatta
    10621 tatattaaac agttgggggt aactgatgtt agtttaatac aacagtattc aggtataatt
    10681 tttggatgta cctttgtagt agcagcattc ttttcgccaa tttgagggaa agctgctgat
    10741 aaatatggaa gaaaatcaat gcttttacgt gcaagtattg ggatgggaat agttatattt
    10801 accatggcgt ttgttcaaaa tgtttatcag ttattaggat taagaatact tcaaggagtt
    10861 tttacgggtt atgctactgc atgtactact cttattgcaa cacagacaga taaaaatcat
    10921 tcaggatggg ctttgggtac tcttgcaact gcatcaacta ctggctcatt aattggtcca
    10981 acagtaggag gatatataga atcaatctta ggtcttaaaa gtacatttat tataacagga
    11041 ggattgttgt ttgtatcatt tatcatctct attttatttg tagtagataa ttttaaacct
    11101 aaagaaataa aagaatcaat ttctatacct aaagaacaat taaatatatt gccaaataaa
    11161 tttttaattg catctatttt tgtaaccaca ttcattactc aactagcttt atactctata
    11221 gaaccaattg taaccatata tatatcacaa cttacaaatt ttgcatcaaa tgtagcttta
    11281 atagctggat tgacattttc tgcatcagga ttagcaaatt tattagcagc tcaaaaactt
    11341 ggaaaaatgt cggataaaat aggtcctcaa aaagtattgt taatttcact tttatgggct
    11401 gggattatat ttataccaca agcttttgta aaaactgcat ggcaactgat gttgttgaga
    11461 tttttattag ggttgtcagt tgcagggctt aatccttctg ttaacagctt gcttaaaaaa
    11521 attgcaccag aagaatatgt gggaaaaata tttggatata atgcatctgc ccagtatata
    11581 ggctgttcat caggagcatt tttaggggga caaatatcag cacatttagg tattagaaca
    11641 gtattttttt caacaagttt attgttgttt aggaatgcac tttggatgta taaatttact
    11701 ggattgttta ttaaagataa gactaaataa tcatactatt tacatttcta attttatgat
    11761 gtaaaataaa tattttttat gtaatttatc atagaattat ataaaaaata accctatggt
    11821 aaaaattgga aaatattatt atcgacaaaa tctttgactt aaaaactata ttgcgatagt
    11881 attaatttaa taaaagtttg agaggggcgt aaggttatga caatttcaaa aataccacaa
    11941 gcagaattaa aagttatgaa gtttatttgg gaaaaaaatg atacagtaac atcaaaagaa
    12001 actattgaag ctatggaacg aaaatatggt tggaaacaaa caactacatt gacactttta
    12061 tcaagacttg ttaaaaaaca ttttttaagt gcagaaaaaa tagatagata cactcattat
    12121 acaatagttg ttggacataa ggagtattta agtgttgaga caaaagattt tttaagcaat
    12181 atacacgaca attctttaca gagtttaatt tcagcactac atgatgatga agttgttgat
    12241 aaagatatgt tggatttatt tgaaagtcat tttaaaaatt tagaagaaga gtaattatat
    12301 caggatagaa ctctaagaat ttaattaatc tatggctgaa aaccataaat ggtattattt
    12361 aatcagctac tcactattca taaagtaata ttaaataggt tctctaatta gtaaaatgcc
    12421 taaaataatt ggaataggga gtatcaagtt aaatgatacc acttatttaa ataagaaatg
    12481 atttttaaaa tttaaaataa ttttataact tgtcaatatt cattaatcta aagtattatt
    12541 tctatttaac ca
//
LOCUS       DAEQCW010000107        12549 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.108, whole genome shotgun sequence.
ACCESSION   DAEQCW010000107 DAEQCW010000000
VERSION     DAEQCW010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12549)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12549)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12549
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.108"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(95..1051)
                     /locus_tag="KRO40_002946"
     CDS             complement(95..1051)
                     /locus_tag="KRO40_002946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBH2093755.1"
                     /translation="MSGLKKFVIFLALLVIAFPVSIYGYVFTKLKTIQDDSINTEALS
                     SNDYKNEENITNILLLGTDARPGEEVSRSDAMMILTIDNKNKSLKLTSLNRDTYVNIP
                     GRGEQKLTHAYVYGQANLLIETIEENFQLDIQNYAVVDFFSFMDIVDALGGVTVTVDK
                     SEIRELNKFIPETYKWNKNDNKGSLKYIRNSGEQKLNGYQTLAFSRIRKNDSTDERDR
                     RQRSVIQSLINGVKDLPVTKYPNLVNTILPYVKTNMNPNEIISLGKELLSIGNLNLKS
                     MEFPLSTENGRKIGNAGYVIPFEEYELDAMHDFIFKDIMVED"
     gene            1419..2207
                     /locus_tag="KRO40_002947"
     CDS             1419..2207
                     /locus_tag="KRO40_002947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBH2093756.1"
                     /translation="MIKLIATDLDGTLLDEKSEINPEFYKVFKKLRERGIMFSAASGR
                     QYQNLIKKFEDIKDDMMFISENGTLVVYKGKEILSNPLNKELVNEIIETTRSIKGKKI
                     VMSGKKYAYIESKDEAFIQEVSTYYAKFKIVEDLTKVEGDILKIAVFDFKGAEHNNNI
                     YFEKFSDRAQVCISGVEWLDLTAKGANKGSAIKKVQKMLDIKYEETMVFGDQLNDVEM
                     MKSAYHSYAMENANEHLKQIARFRAKRNTENGVVDKIKEVIKIG"
     gene            complement(2330..2800)
                     /locus_tag="KRO40_002948"
     CDS             complement(2330..2800)
                     /locus_tag="KRO40_002948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4358 domain-containing protein"
                     /protein_id="HBH2093757.1"
                     /translation="MKKILILFFSIILSLGMVSCSSSGDYKNVSTSKIKKALKSSDLL
                     IKESKIFDAKDFNYFNDVEEDIIQGFVINSSEKLSLEDIIVIKTDEVDKIYKTLENYK
                     KDMIQAPFGEGHGEKINSEIANNTIIEKAGRYVYLISAENATQIENKILNIIKK"
     gene            2939..3583
                     /gene="uppS"
                     /locus_tag="KRO40_002949"
     CDS             2939..3583
                     /gene="uppS"
                     /locus_tag="KRO40_002949"
                     /EC_number="2.5.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="di-trans,poly-cis-decaprenylcistransferase"
                     /protein_id="HBH2093758.1"
                     /translation="MRIPKHVGIIPDGNRRWASQNGMTKDKGYESGIDPGLESYRLCR
                     DLGCEEVTFYGFTTDNTRRPSVQTKAFTKACIDAANILIDEGAALLVVGNTKSPMFPE
                     ELLPYTNRIKAKEGQIKANLLVNYGWYWDLNNISGVENVNKNNIQDYIQSFDVSRLDL
                     IIRWGGRRRLSGFLPVQSIYADFYVIDNYWPDFKSDDIKDAFSWYDTQDVTLGG"
     gene            3626..4531
                     /locus_tag="KRO40_002950"
     CDS             3626..4531
                     /locus_tag="KRO40_002950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2093759.1"
                     /translation="MKKKLLDGKITLIICKSVKIYTKKGEEMSKGNNNNNSRNKSKKT
                     SHLNRKKRKLNKKKLAVLICFTVLFLFIAFKATQGVVALVKSMDKSNKTNQQQNVNSE
                     QFDLGNEEENKKKKYTVFIDPGHGGNDKGTESKTSNRYEKDLNLQIAKKLANKLSKQK
                     DIQVVVSRTDDTYISLKDRAILANNSSADVLVSIHLNAEKNGNTATGIETWYRNKATD
                     GSKELAQTVQSTIVSYVKVRDRGIVENNFEVLRESNMPAILIECGFLTTPSEEQKIIN
                     EKYQDQLAEGIVQGVLSYLDSKGNK"
     gene            4846..6393
                     /locus_tag="KRO40_002951"
     CDS             4846..6393
                     /locus_tag="KRO40_002951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093760.1"
                     /translation="MNKNSMTRIYSLNKIIFIIIGILGIVLLTRHIEVDIKVLILILL
                     TLFSINVFISYLKIKLYEDKINLGLINNSDKFINITKDENFLKHVQNYIISNEKENCV
                     MACFDLCRLKLINDIYGYELGDEVLNNILSNLKNYFGKEAIYGKLKSDVFVLIIKLEN
                     REQKIPYLVNLIKNKIVILSQIDSFKMDINIEASIGIYKFNNNEIDIKKAIDNADMAR
                     LKSKGLKHIEYVEFDNAMEEEIQSIMKIERDLFLAIKNKEFVIHYQPKVDSSTGNIIG
                     SEALIRWLHPSLGMVGPNKFIPIAEKNGLINNIGRWLIQEVFITINKWISEGINVLPV
                     SINLSRVELYKNDLVDFFKLMFNTYNIPKELIELEITETTALRDVKFISERLYEIKSL
                     GMNISLDDFGVGNSNFINLKGIPLDIIKIDRSLILDIVTNTKTKFMVKAIVNLSHDLN
                     VTVICEGVEDMHQVKVLSELGCNFIQGYVFFKPLDEMNYKKLLTDGSYINLKDTLLDK
                     CMTVEEE"
     gene            6396..6794
                     /locus_tag="KRO40_002952"
     CDS             6396..6794
                     /locus_tag="KRO40_002952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBH2093761.1"
                     /translation="MISEDVDYSIRIIRAIFNNGEDKPIDAKMILKSEDIPILTLYRL
                     LRKLCANNILTFNKEDGKTYMLNVSLDTISLRTIVEVIDGKIYINKCTRYVSNCSNCL
                     KGCKVNRELLEIEKEIYKLLSRKSIRQILE"
     gene            6834..8567
                     /locus_tag="KRO40_002953"
     CDS             6834..8567
                     /locus_tag="KRO40_002953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HBH2093762.1"
                     /translation="MDDISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKT
                     LKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIH
                     RHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLKKKWRYKFD
                     YIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVIT
                     PRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYID
                     VFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKC
                     KYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEY
                     RLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKK
                     IMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKI
                     TAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIK
                     MDNLIMDSLGI"
     gene            8799..10010
                     /locus_tag="KRO40_002954"
     CDS             8799..10010
                     /locus_tag="KRO40_002954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH2093763.1"
                     /translation="MKGLVLEGGGTKGAYQIGAYKALRELGIEFQGVTGTSIGALNGA
                     YIVQNDIEVMEDIWLNYDYTHFMNIDRETYERFKNVDFTTKNLNAVFELINKARKNEG
                     IDISPLRQLMETTLNEDIIRKSKKDFGLVTVWWDKKINPYPLYIEDIPKGRLIDYLIA
                     SSSLPIFQTNMMDDKLYLDGMFCDNMPIGLLEDKGYEDVVVIRLIDDFIGKMNLNRHQ
                     NINIKTIIPSEYLGGSLNKDRDNVEKNIRLGYLDTMKAYERCTGIKYYFDVEYKYNEE
                     YCFDKFRSMSNETIQYICNLLNIKRDASLRTVMESVIPKLGEVLGLPKDFSYKDLFYC
                     IYEKKLEENNINRIKLYDFNKVIDVVNTNIDSNRNLASNFEVRPKISIKKNKNTKLLT
                     NCIIKDIKNQS"
     gene            10203..10463
                     /locus_tag="KRO40_002955"
     CDS             10203..10463
                     /locus_tag="KRO40_002955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr family phosphocarrier protein"
                     /protein_id="HBH2093764.1"
                     /translation="MEKVVSIKNASGLHARPAGMFVKKAAEFKSTVEVVAKDKTVNAK
                     SIMGIMSLGLAQGEELKLVVNGEDEEVALAAMVELVESGFGE"
     gene            10817..12529
                     /gene="ptsP"
                     /locus_tag="KRO40_002956"
     CDS             10817..12529
                     /gene="ptsP"
                     /locus_tag="KRO40_002956"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HBH2093765.1"
                     /translation="MAYKGIGASPGVALGKALVVEHSELVIEKKSIDNVEAEIAKLED
                     AVAVSKEELVKVKEKASEELGAEEAEIFEAHLLVLEDPELIGSAIDKIKTESVNAEYA
                     LNEIKEMFVSMFESMDNEYMKERAADIKDVTNRILRHILGIKVVDLSALSEEVVLIAH
                     DLTPSDTATMNKKMVLGFLTDIGGRTSHTAIMSRTLEIAAIVGLNDITSKVKDGDFVV
                     FNGDTGEVIVNPDEETINKYTELKAKYEDERKALQLLKGKPSVTLDGKHVELAGNIGT
                     PNDIEGLIKNDAEGVGLYRTEFLYMDRDSFPTEEIQYEAYKAVLEGMDGKPIVIRTLD
                     IGGDKELSYLSMEPEMNPFLGYRAIRLCLDRKDIFKTQLRALYRASVHGRLRIMFPMI
                     SSLEELLQAKEVVKEVLAELDSEGVAYAKDVEIGMMIEVPSAAVISDVLAKHVDFFSI
                     GTNDLIQYTCAVDRMNQKISYLYNQFNPAVLRLIKTVIDNAHKEGKWAGMCGESAGDQ
                     KMIPILLGMGLDEFSMSPISILPARKLITSVKESDMKKLADDVFNMGTAEEIKSYIEK
                     TFNI"
BASE COUNT         5081 a         1222 c         2099 g         4147 t
ORIGIN      
        1 tattttaaaa taaaaacaca ccccataaat acaaagtaat ttgcatttaa gaggtatgta
       61 tttatcatca aattattggt ttgttttgga atttctaatc ttcaaccata atatctttaa
      121 atatgaaatc atgcattgca tctagttcat attcctcaaa aggtattaca tagcctgcat
      181 tacctatttt tctaccattt tcagtagaaa gaggaaactc catagatttc aaatttaaat
      241 ttcctatact taaaagttct tttcctaaag atattatttc attaggattc atattagttt
      301 ttacatacgg aagtattgtg ttaactagat taggatattt agtgactggt aaatccttaa
      361 caccatttat taaactctgt ataacacttc tttgtcttct atctctttca tctgtactat
      421 cattttttct tatacgagaa aatgcaagtg tctgatatcc atttaatttt tgctcaccag
      481 aatttcttat atatttaaga gaacctttat tgtcattttt attccattta taagtttcag
      541 gaataaattt atttaattct cttatttcac tcttatcaac agtaacagta actccaccta
      601 aagcatcaac tatatccata aaagagaaaa agtcaactac ggcgtagttt tgtatatcaa
      661 gttggaagtt ttcttctata gtttctatta ataagttagc ttgtccatat acgtaggcat
      721 gtgttaattt ttgttctcca cgtcctggta tattaacata agtatctcta tttaatgaag
      781 ttagcttaag acttttattt ttattatcaa tagtaagtat catcatggca tcagaacgag
      841 aaacttcttc tcctggtctt gcatctgtac ctaacaataa tatgtttgtg atattttctt
      901 cgtttttata gtcattacta ctaagcgcct ctgtatttat actatcatct tgtatagttt
      961 ttaatttagt aaaaacatat ccatatatac taacaggaaa tgctataact aaaagggcta
     1021 gaaatataac gaactttttg agtcctgaca ataatatccc ctactttcta aattttttaa
     1081 ttacacatag ttaattatat taaaaatttg ttacataagc aataaaaaac acaataaatt
     1141 agcataagtt tgtcataata taattatttt tatagcattt tatagaagaa agtgtgtagt
     1201 tattattgat tttattggaa tataattgta tgaagactta aatttttata aactgatgtg
     1261 tatattgaaa aaaatatttt cctgaatgta gttatagcat cttatgaaag gtgcaaattg
     1321 taatttaaaa tttttagtgt ataataagaa ttgaaaattc aaaccgataa aaattaataa
     1381 aaaataatta taaattaata atttggggga ggaaatgtat gataaaatta atagcaacag
     1441 atttagatgg aactttgtta gatgaaaaga gcgaaataaa tccagagttt tataaagtat
     1501 ttaaaaaatt aagagagaga gggataatgt tttctgctgc tagtggcagg cagtatcaaa
     1561 atcttataaa aaaatttgaa gatataaaag atgatatgat gtttatatca gaaaatggaa
     1621 cactagtagt atataaagga aaagaaatat tatcaaatcc tttaaataaa gaattagtaa
     1681 atgaaatcat agagacaaca agaagtataa aagggaaaaa aattgtaatg agtgggaaaa
     1741 aatacgctta tatagaaagc aaagatgaag cgtttataca agaggtcagt acttattatg
     1801 caaagtttaa aattgtagaa gatttgacga aagtagaagg agacatattg aagatagctg
     1861 tatttgactt caaaggtgca gaacataata ataatatcta ctttgaaaag ttttctgata
     1921 gagctcaagt atgtatttct ggagtggagt ggcttgattt aactgcaaaa ggtgcaaata
     1981 aagggagtgc cataaaaaaa gtacaaaaaa tgttagatat aaaatatgaa gaaactatgg
     2041 tatttggtga ccagttaaat gatgtggaaa tgatgaaaag tgcctatcat agttatgcca
     2101 tggaaaatgc aaatgaacat ttgaaacaaa ttgctagatt tagagcaaaa agaaatactg
     2161 aaaatggcgt tgtagataag ataaaagagg ttataaaaat tggatagtca tatgtataga
     2221 tgaaaaagat tattttgaag aaatcaaaaa aatatcaatg taattttgat aaataagttt
     2281 atttatgcga aaattacatt gatatttaat aaacatcaat aatagatatt tattttttta
     2341 tgatattcag tattttgttt tctatttgag ttgcattttc agcagaaatt aaataaacat
     2401 atctacctgc cttctcaatt atagtattat ttgctatttc agaattgatt ttttctccat
     2461 gtccttctcc aaaaggtgct tgtatcatat cttttttata attttctaga gttttataga
     2521 ttttatctac ctcgtcagtt tttataacga taatatcttc tagagataat ttttcagaag
     2581 aattaattac aaaaccttga attatgtctt cctctacatc attaaaatag ttaaaatcct
     2641 ttgcatcaaa gatttttgat tcctttataa gtaaatcaga agattttaat gcttttttta
     2701 tttttgatgt agaaacgttt ttgtaatcac cacttgaaga acaactaacc attcctaatg
     2761 ataagattat cgaaaaaaac aatattaaaa tttttttcat gataaacctc caagtttttt
     2821 aaactctgtc ttaaattagt ttactacata attatataaa aataaatgta tttaatgtta
     2881 cagttttgat taataatgta atattttgat aataatacct attgagaggt gattagaaat
     2941 gagaatacca aaacatgtag gaattatacc ggatggaaat agaaggtggg caagtcaaaa
     3001 tggtatgaca aaagataaag gatatgaaag tggaatagac cctggactag agtcttatag
     3061 attatgtaga gatttaggct gtgaagaggt gactttttat ggatttacaa ctgataatac
     3121 aagacgtcca tcagtgcaga caaaagcttt tacaaaagca tgtattgatg ctgcaaatat
     3181 attaatagat gaaggtgctg ctttattagt tgtaggaaat acaaaatctc caatgtttcc
     3241 agaagaatta ttaccatata ctaatagaat taaagccaaa gaaggtcaaa taaaagcaaa
     3301 tcttctggta aattatggtt ggtattggga cttaaataat atatcaggag tagaaaatgt
     3361 aaataaaaat aatatacagg attacataca gtcatttgat gtatccagac tagacttgat
     3421 aatcagatgg ggtggaagaa ggagattaag tggtttcctt cctgtacaat caatttatgc
     3481 agatttttat gttatagata attattggcc agattttaag agtgacgata taaaggacgc
     3541 atttagttgg tatgatacac aagatgtcac tttaggtgga taattaaaaa tattctgatt
     3601 taaggttgta gagtgtttta aattattgaa aaaaaaactt cttgatggta aaataacact
     3661 aataatatgt aaaagtgtaa aaatttatac caagaagggt gaagaaatgt caaaaggcaa
     3721 taataacaat aattcaagaa acaaatctaa aaagaccagt catctgaata gaaaaaagcg
     3781 aaaattaaat aagaaaaagt tagcagtgtt gatttgcttt acagttttat ttttatttat
     3841 tgcatttaag gctactcaag gtgtagtagc tttggtaaaa agtatggata aaagtaataa
     3901 aactaatcaa caacaaaatg ttaactcaga acaatttgac cttggtaatg aagaggaaaa
     3961 taaaaagaaa aaatatactg tatttataga cccaggtcat ggaggcaatg ataaaggaac
     4021 tgaaagcaag accagtaata gatatgaaaa agacctaaat ctacaaattg caaaaaaatt
     4081 agcaaataaa ttatctaaac aaaaggatat tcaagtagta gtatccagaa ctgatgatac
     4141 atatatatca ttaaaggata gagctatctt agcaaataat agttctgctg atgtgcttgt
     4201 ttctattcat ttaaatgcag agaaaaatgg taatacagca acaggtatag aaacttggta
     4261 taggaataaa gctacagatg gttcaaaaga acttgcacag acagtacaaa gtactatagt
     4321 atcctatgtt aaagttagag ataggggaat agttgaaaat aactttgaag tacttagaga
     4381 atcaaatatg cctgctatat taatagagtg tggtttttta acaacacctt cagaggaaca
     4441 aaaaataata aatgaaaaat atcaagacca acttgcggaa ggaattgttc aaggtgtact
     4501 ttcataccta gattctaaag ggaataagta agttaacttt actttaatgt gaggataaat
     4561 ttaaaagttt aactgtgtaa attgtattaa ctttatttcg taatgttgca aacattgttt
     4621 gaatttagaa actatgaaat tagaaattat tttatctata tctaatttca tagttttttt
     4681 tgcaaaaaat ttatagttat aaaattttaa aaaataaatt tagtataatg taatgtagtt
     4741 atttatatgt gattttaact tgcattgatt tgctatcaat tgtgctttat aattagtata
     4801 tataaagttt aactgtaaga taatttaaaa aataggggaa tttatatgaa taaaaatagc
     4861 atgacaagaa tttacagttt aaataaaata atttttatta taattggaat tttaggaata
     4921 gttttactca caagacatat tgaggtagat attaaagttt taattttaat tttattaacc
     4981 ttgtttagta taaatgtatt tatttcatat cttaaaatta agttgtatga ggataaaatt
     5041 aatttaggat tgataaataa ttcagataag tttataaata ttactaaaga tgagaacttc
     5101 ctaaaacatg ttcaaaatta tattatcagt aatgaaaaag aaaactgtgt aatggcttgt
     5161 tttgatttat gtagactcaa acttataaat gatatatatg gttatgagct aggggatgaa
     5221 gtgttaaata atattttaag taacttaaaa aattattttg gaaaagaagc tatttatgga
     5281 aagttaaaaa gtgatgtttt tgtattaata ataaagcttg aaaataggga acagaagatt
     5341 ccttatttag taaatcttat taagaataaa attgtgatac taagtcagat tgacagtttt
     5401 aaaatggata taaatattga ggcttctatt ggaatttata aatttaacaa taatgaaatt
     5461 gatataaaaa aagctataga taatgctgat atggcaagac ttaaatcaaa aggactaaag
     5521 cacatagagt atgtagaatt tgataatgct atggaagaag aaatacaatc aattatgaaa
     5581 atagagagag atttattctt ggctattaaa aataaagagt ttgtaattca ctatcaacct
     5641 aaagttgatt caagtacagg taacattata ggttcagagg cattgataag atggttgcac
     5701 ccatcattag gcatggttgg accaaataag tttataccta tagctgaaaa aaatggtctg
     5761 ataaacaata ttggtagatg gctaattcaa gaagttttta ttaccattaa caagtggatt
     5821 tcagaaggta taaatgtctt accagtctca ataaatcttt ctagagtaga actatataaa
     5881 aatgatttag ttgatttttt taaactgatg tttaatacat ataatattcc aaaagaactt
     5941 atagaattag aaattacaga aacgacagca ctaagagatg taaaatttat aagtgaaagg
     6001 ctttatgaga ttaaatcttt aggtatgaat atatcattag atgattttgg agtaggtaat
     6061 tcaaatttta tcaaccttaa ggggatacca ctagatatta taaaaattga taggtcactt
     6121 atattggata tagttacaaa tacaaaaaca aagtttatgg tgaaagcaat tgttaacctt
     6181 tcacatgatt taaacgtaac tgttatatgt gaaggggtag aggatatgca tcaggtcaaa
     6241 gtcttaagtg aactgggatg taatttcata caaggttatg tattttttaa acctttggat
     6301 gagatgaatt ataaaaaact tcttactgac ggaagttata taaatctgaa agatactctt
     6361 ttagataaat gcatgacagt tgaggaggag taaggatgat ttcagaagat gtagattatt
     6421 caataagaat cataagagct atatttaata atggagaaga taaaccaata gatgctaaaa
     6481 tgatattaaa aagtgaagat ataccaatac taacactata cagactgctt agaaagcttt
     6541 gtgcaaacaa tattcttact tttaacaaag aagatggcaa gacatacatg ttaaatgtgt
     6601 cattggatac aataagtcta agaactattg tagaagtaat tgatggaaaa atatatataa
     6661 ataaatgtac gagatatgta tctaattgca gtaattgctt aaaaggttgt aaagtaaatc
     6721 gtgaattgct agaaatagaa aaagaaattt ataaactttt atcgagaaaa tctataagac
     6781 aaatactaga ataaaaaatt ttcagctatg ataataattg gaggttttcg gttatggatg
     6841 atatatctca agacaatttt ctactgtcta aagagtatga gaatagctta gatgtagata
     6901 ctaaaaaagc aagtggaata tattatactc ctaaaataat tgtagattat attgtaaaaa
     6961 aaactttaaa aaatcacgat ataattaaaa atccatatcc acgaatactt gatatttcct
     7021 gtgggtgtgg aaattttctt ttagaagtat atgatatttt atatgactta tttgaggaaa
     7081 atatatatga attgaaaaag aagtatgatg aaaattattg gactgttgat aacatacacc
     7141 gtcatatatt aaactattgt atatatggtg ctgatattga tgaaaaagct ataagtatat
     7201 taaaagatag cttaacaaat aaaaaggtag taaatgattt agatgaatct gatataaaga
     7261 ttaatctatt ttgttgtgat agtcttaaaa agaaatggcg atataagttt gattacatag
     7321 tgggtaatcc accctatatt ggtcataaaa aacttgaaaa gaaatataaa aaatttctcc
     7381 tagaaaaata tagtgaagtt tataaggata aagctgactt atatttttgt ttttataaaa
     7441 agattataga tattttaaag caaggaggga ttggcagtgt tataactcca agatattttt
     7501 tagaaagtct atcaggtaaa gatttaagag aatatattaa atcaaatgtc aatgttcaag
     7561 aaatagtgga ttttttaggt gcaaatatat ttaaaaatat aggggtatct agttgtattc
     7621 taacttttga taagaaaaaa acaaaagaga catatataga tgtatttaaa atcaaaaatg
     7681 aggatatatg tataaataaa tttgaaacat tggaagaact tctaaagagt agcaaatttg
     7741 aacattttaa tataaatcag agattgctat ctgacgaatg gatacttgta aataaagatg
     7801 atgaaacttt ttataataag atacaagaaa aatgtaaata tagcttggaa gatatagcaa
     7861 taagttttca aggaataatt acagggtgtg ataaagcgtt tattttaagt aaagatgatg
     7921 taaagttgaa ccttgtagat gataaatttt taaaatgttg gataaaaagt aagaatataa
     7981 ataaatatat agtagataaa agtgaatata ggctaatata ctcaaatgat atagataatg
     8041 agaatacaaa taaaaggata ctagatgaaa ttatagggct atataaaaca aaattagaaa
     8101 acagaagaga atgtaaaagt ggaataagga aatggtatga acttcaatgg ggtagagaaa
     8161 agcttttctt tgaaagaaaa aagataatgt atccttataa atcaaatgaa aatagatttg
     8221 ctatagatta tgataataat ttttcaagtg cagatgtata ttcttttttt ataaaagaag
     8281 agtatttaga taaattttca tatgaatatc tagttggaat tttaaattcc agtgtttatg
     8341 ataaatactt taaaataact gctaaaaaaa tgagtaaaaa tatatatgat tactatccta
     8401 ataaggttat gaagataagg atttttagag ataataatta tgaagagata gagaatttat
     8461 caaagcaaat aatatcaatt ttattaaata agtctataga taaaggaaaa gtagaaaaat
     8521 tgcagataaa aatggataac ttgataatgg attctttagg tatataagca gttgtaagta
     8581 ttaaaaaatt ataatctttt aattgtttat ttaaatttag aaataaaaag ttagccatat
     8641 aaaaaatatt aaaaatatat acttttcaat atttttttga taaaataaga atgaatttgt
     8701 gcaattttat ttttctccaa taactaaaaa tagttttttg aattaatatt tgcttaagaa
     8761 taaaaatcag aaacgttttt gatatagtag gtgataatat gaaaggatta gttttagaag
     8821 gtggaggaac aaaaggagcc taccaaatag gtgcatataa agctttaaga gagcttggta
     8881 tagagtttca aggagtaact ggcacatcaa ttggtgcttt aaatggagca tatatagttc
     8941 aaaatgatat tgaagtaatg gaagatattt ggttaaatta tgactatact cattttatga
     9001 atattgatag agaaacctat gagaggttta aaaatgtaga tttcactact aaaaatctca
     9061 atgcagtgtt tgagcttata aataaagcta gaaaaaatga aggtatagat ataagcccat
     9121 taagacaact aatggagaca acattaaatg aagacataat aaggaaatca aaaaaagact
     9181 ttggacttgt tacggtctgg tgggataaaa aaattaatcc atatccattg tatatcgaag
     9241 atatacctaa aggaagattg attgattatt taattgctag ttccagtttg cctatttttc
     9301 aaacgaacat gatggatgat aagttgtatc ttgatggaat gttttgtgat aacatgccaa
     9361 taggactctt ggaagacaaa ggttatgaag atgttgttgt aattaggttg attgatgatt
     9421 ttattgggaa aatgaatcta aatcgacatc aaaatataaa tataaaaact ataataccat
     9481 cagaatatct aggaggttct cttaataaag atagagataa tgtagaaaaa aacatccgac
     9541 taggttactt agatactatg aaagcatatg aaagatgcac tggaattaag tattattttg
     9601 atgtagagta taaatataat gaagaatatt gttttgataa atttagaagt atgagtaatg
     9661 aaacaataca atatatctgt aatttattga atataaaaag agatgcttca cttagaaccg
     9721 ttatggaaag tgtaatacca aagcttggtg aggtgcttgg attgccaaag gatttttcat
     9781 ataaagattt gttttactgt atatatgaaa agaaacttga agaaaataat ataaacagga
     9841 taaaattata tgattttaac aaggttatag atgttgtaaa tacaaatatt gattctaata
     9901 gaaatttagc ttctaatttt gaagttagac ctaaaattag tattaaaaag aacaaaaaca
     9961 caaaattatt gacaaattgt attataaaag acataaaaaa tcaaagttaa ataaaaaaca
    10021 aaaaaaaatt tgtaattata ctcgaaaaaa gtgtatatta gtagtataat atttttgtag
    10081 cactagtggg aacaaaaaat gaccatagga caaaaaagta ccacttagta ccattaaagt
    10141 aaaaaacagg aaaacaattt taaaaaatat aaaatgtaaa gtttatagga ggatttaaaa
    10201 aaatggaaaa agtagttagt atcaaaaatg caagtggatt acatgctaga ccagcaggaa
    10261 tgtttgttaa gaaggcagct gaatttaaat caacagtaga ggttgtagca aaagacaaaa
    10321 ctgtaaatgc aaaatcaata atgggaataa tgagtttagg tttagctcaa ggagaagaat
    10381 taaagttagt tgtaaatgga gaagatgaag aagtagcttt agctgcaatg gttgaattag
    10441 ttgaaagtgg atttggagaa tagatataat aattttttaa aaatttgata tttagaatct
    10501 aatattactt aaagtaaagt aacagagaag tattaaacat atacagacca acatttgtag
    10561 atatttaatt tctttgttac tttcatgttt atttaatcag aagattaaga ctattgttaa
    10621 ttgggtataa aaatataaat attttagaaa atgaaataag atatttttaa tcataaattc
    10681 agagtaaaaa tacagtaaca aatagtttat aaaattttat aaaaaattat aagtaaataa
    10741 aactataaaa atgtaaatta tttatataaa tttataaagt ttatgtgcta gatgatattt
    10801 tttaggaggt agggttatgg cttacaaagg aataggtgct tctcctggtg ttgctttagg
    10861 gaaagcgtta gtagttgaac atagtgaatt agtaattgaa aaaaaatcta tagataatgt
    10921 tgaagctgaa attgctaaat tagaagatgc agttgcagtt tctaaagaag aattagtaaa
    10981 agttaaggaa aaggcttctg aagaattagg agcagaggaa gcagaaatat ttgaagcaca
    11041 tttattagtt ttagaagacc cagagttaat tggttctgca atagataaaa ttaaaactga
    11101 aagtgtaaat gcagagtatg ctttaaatga aataaaagag atgtttgtta gcatgtttga
    11161 gtctatggac aatgagtaca tgaaagaaag agcggcagat ataaaagatg ttacaaatag
    11221 aatacttaga catatattag gaattaaagt tgttgattta tctgctttaa gcgaagaagt
    11281 tgtattaata gcacatgatt taactccatc agacacagca actatgaata aaaaaatggt
    11341 tttaggattt ttaactgata taggtggaag aacttctcat actgctatca tgtctagaac
    11401 tttagaaata gctgcaatcg ttggattaaa tgatataact tcaaaagtta aggatggaga
    11461 ttttgtggtt ttcaatggag acacaggtga agtaatcgtg aatcctgatg aagagactat
    11521 aaataaatat actgaattaa aagctaagta tgaagatgag agaaaagcat tacagctatt
    11581 aaaaggaaaa ccatctgtaa ctttagatgg aaaacatgtg gaattagctg gtaacatagg
    11641 aacacctaac gatatagaag gtctaataaa gaatgatgct gaaggtgttg gtctttatag
    11701 aacagaattt ttatacatgg atagagattc tttcccaaca gaagaaatac aatatgaagc
    11761 atacaaagct gtattagaag gaatggatgg aaagcctata gttataagaa cattggatat
    11821 aggtggagat aaagaattaa gttatttaag tatggaacct gaaatgaatc cattcttagg
    11881 ttacagagca ataagacttt gcctagatag aaaagatata tttaagactc aattgagagc
    11941 tttatataga gctagtgttc atggaagatt aagaatcatg ttcccaatga tttcatcttt
    12001 agaagagttg ttacaagcta aagaagttgt aaaagaagtt ttagcagaac ttgattctga
    12061 aggtgtggct tatgctaaag atgtagaaat tggtatgatg atagaagttc catctgctgc
    12121 tgtgatatct gatgtattgg ctaaacacgt agatttcttc tctataggaa ctaatgattt
    12181 aattcaatac acttgtgcag ttgatagaat gaatcaaaag ataagttatc tttacaatca
    12241 atttaatcca gctgttttaa gacttataaa gactgttata gacaatgcac ataaagaagg
    12301 aaaatgggca ggtatgtgtg gagaatctgc tggagaccaa aaaatgatac caatactttt
    12361 aggtatggga ttagacgagt tctctatgtc tccaatatca atacttcctg ctagaaagtt
    12421 aataacttca gttaaagagt cagatatgaa aaaattagct gatgatgtat ttaatatggg
    12481 tactgctgaa gaaataaaaa gctatataga aaagactttt aatatataat taatgttata
    12541 tagttacta
//
LOCUS       DAEQCW010000108        12503 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.109, whole genome shotgun sequence.
ACCESSION   DAEQCW010000108 DAEQCW010000000
VERSION     DAEQCW010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12503)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12503)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12503
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.109"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            277..558
                     /locus_tag="KRO40_002957"
     CDS             277..558
                     /locus_tag="KRO40_002957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093766.1"
                     /translation="MKEKYKWRKSTTEILLGRLVKMRILKKKRVGFQLNYEVLVTKKE
                     YLDVIKEEKDVSKYDNFFTQVFTTIHKKEEKTEKQIKVFIESMQKLGKK"
     gene            598..984
                     /locus_tag="KRO40_002958"
     CDS             598..984
                     /locus_tag="KRO40_002958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2093767.1"
                     /translation="MLNKKLPDSEFKIMKYIWNTGYKTVISKDVADEMEKIYKWKQTT
                     TLTLLLRLTKRGFLASQKIGKHTHYTILIKEKEYLKSETKKLFGGLHNNPLSQLISKL
                     HDKEEVSIDKIDALEEWLRSLQEDEE"
     gene            1708..2154
                     /locus_tag="KRO40_002959"
     CDS             1708..2154
                     /locus_tag="KRO40_002959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093768.1"
                     /translation="MAISDLAFGTECLKTSFQMLFSVISLVNINLLQAQILIAIGGLI
                     SILAMVSLTLFLSAKCKDSLTSMQIAFSICLIPMGIGVSWIGYLLPPGGIGFKISLLY
                     QMTSFNFLHLGGMSFWTPHIILFFSVIEIPIFIFLAIRTYCKHQVS"
     gene            2535..3452
                     /gene="pstC"
                     /locus_tag="KRO40_002960"
     CDS             2535..3452
                     /gene="pstC"
                     /locus_tag="KRO40_002960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HBH2093769.1"
                     /translation="MIVKSRLVGLEKNDNNGNKTKYVIEKVAKNIFLLSALVAVASLL
                     LIIGFVFYKGLRPFIFEGYSFIDFLTGADWVPSANKFGISSMIVASIFATLGALVIGV
                     PVGILTSVFIAEVAPKRLAKIMSPAVELLAGIPSVLYGVFGLAVIVPTIQSIFNLPKG
                     QSLLAIVIVLAVMMLPTIISVSETAIRAVPKAYKEGSLALGASKIETIFKVVLPAAKS
                     GVLAAVVLGVGRALGETMAVILVAGNSPVMPTAITDSVRPLTTNIALEMGYAFGTHQE
                     MLFATGVVLFTFILILNLVLNKLSNKAVN"
     gene            3454..4278
                     /gene="pstA"
                     /locus_tag="KRO40_002961"
     CDS             3454..4278
                     /gene="pstA"
                     /locus_tag="KRO40_002961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003460575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HBH2093770.1"
                     /translation="MRKFKENLLKSLVYLSALFTIVSLVVIVGFIFIKGIGNMNFNFL
                     FSNYSASGDGGILPMIITTLYTVVVSIVVATPIGILAAIYLQEYAKKGKAVTAIRFAT
                     ESLSGIPSIVYGLFGGIFFVVTLKMGYSIVAGSLTVAIIILPVIIRTTEEALKTVPQA
                     YRESSLALGATKFQTLYKVVLPSAIPGILSGVILSVGRIIGESAAILLTAGTVAKMPG
                     GIFDSARTLTVHSYLLTKESGDIATAASIGIVLIVIVLALNMLARFVAKKLNKANY"
     gene            4297..5061
                     /gene="pstB"
                     /locus_tag="KRO40_002962"
     CDS             4297..5061
                     /gene="pstB"
                     /locus_tag="KRO40_002962"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HBH2093771.1"
                     /translation="MELIDKIKMSVKDLDLFYGDKQALKKINMDIKENKVTALIGPSG
                     CGKSTFIRTLNRMNDLIEDVTIKGNISVDGEDIYTSDDVINLRTKVGMVFQKPNPFPM
                     SIYDNVAYGPRTHGLRDKKQLDKIVEESLKGAAIWDEVKDRLKSSALGLSGGQQQRIC
                     IARAIAMRPEVILMDEPTSALDPISTLKVEELIEDLKKDYTIVIVTHNMQQAARISDE
                     TAFFLNGEVIEFSDTKTMFTTPVDKRTEDYITGRFG"
     gene            5089..5742
                     /gene="phoU"
                     /locus_tag="KRO40_002963"
     CDS             5089..5742
                     /gene="phoU"
                     /locus_tag="KRO40_002963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HBH2093772.1"
                     /translation="MVNNSLDISIDTLKEQTVLMMEKCEEAIEKSVTCMIEKDLEGAR
                     KVVEDDEEINKLREEIRDKSIELIVLKQPMARDLRFIYSLGNISIELERIGDYAANIA
                     REMLKIGGEAYIKELIDIPKMAKECKSMMSQTREALILFDASIAYDVGTKDDIVDGLY
                     EQVQIDCLKIMHENSNTIDQGVKLLLIGRYLERIGDHITNVCEKIIFAIEGKMVEIG"
     gene            5900..6769
                     /locus_tag="KRO40_002964"
     CDS             5900..6769
                     /locus_tag="KRO40_002964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBH2093773.1"
                     /translation="MKLQKMGMRTIKTGISVTLCMILGDYLVENMFYSLVACIISVQD
                     TVKGSLKTGINRVEGTILGGIIGFIFAIIKAGDPFLCGLGVMCSIYLCNLFKIKSVVV
                     ACVTFLAIHLGVGNSDPVYYSLHRVLDTSVGVLFGVLVNYYVARPNYLNSVIDEFKKI
                     EELSMLLIEDKILRKENLNVEKFEEEVEKLEEIYSKLIDELDYSLSETNIEKIENALR
                     ICREIHFHMQSIELLENKLYLKEHTYKYLKKTYNVDKLDWNIDEEKSPVFNYHLMKIM
                     IEIELLRKLNKSY"
     gene            6856..8292
                     /locus_tag="KRO40_002965"
     CDS             6856..8292
                     /locus_tag="KRO40_002965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase"
                     /protein_id="HBH2093774.1"
                     /translation="MNTRNDNSKILEIYKMKLFGELVKAVWNDDIEDIENLPNKILNE
                     DLKDNLNNYFSGKFDKDTMVNLIRVTMGLDVTEDTDKNLKESLHEAVNLDEVKRPIIS
                     VISDACKYCDENNKEDESCKIRSKHINCNEEDVCSACGDCVSRCKLGAISDKIEFIPM
                     IKLLKDIKSPVYAIVAPAFVGQFGKDVSPGKLRTALKKIGFEDMIEVALAADMLTAKE
                     AYDYYEHMKKDEEGCFITSCCCPIWVSLIQNSFPQILENVSPSVSPMIACGRAVKILN
                     PDAKVVFIGPCMAKKKEAMLEDIKDAVDFVLTFKELQEIFDALELNPAIMDESNRVEA
                     SLSGRVYARTGGVSKAVKLSVRRIDKNIKFEEKAFEGTKECMDGLKKVLNKEIEATFI
                     EGMGCVGGCVGGPKRILSVEEGTKNVDEYSESTNMETPFDNLNVLQFLTSLGIKRVES
                     LGEKEEEKVKKIFSRDIKSNKKENKYKK"
     gene            8340..9167
                     /locus_tag="KRO40_002966"
     CDS             8340..9167
                     /locus_tag="KRO40_002966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBH2093775.1"
                     /translation="MKIKDNKAVFHVFIRIFLIAVLILTGTLLEEKINNVPVENISSK
                     GENTLELLSQSNTLGEIIYKASQEETKGPGATSEKVAYITIDDGPSKYTNALLDILKE
                     NDVKATFFMLNQNMKNHKEEVRRVLEEENSIGFHSVSHDIHKLYKSPEVTVGEFNTCN
                     NTLQEITGQSSKLIRLPYGSKPYMPEGSYNKLMANDYLIWDWNLDTQDWKSSTSQIVS
                     NILYYGRKRDELVVLIHEKEQSLNALNNIIRILKERGYTILPITENITPKNFWQENL"
     misc_binding    9458..9720
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            9796..12462
                     /locus_tag="KRO40_002967"
     CDS             9796..12462
                     /locus_tag="KRO40_002967"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HBH2093776.1"
                     /translation="MENTNLSKTYNPKDFEARLYKKWMDEGYFKSKPNPDKKPFTIMM
                     PPPNITGQLHMGHALDHTLQDILIRWKRMDGYEAFWLPGTDHASIATEVKVVERIKKQ
                     EGKTKYEIGREEFLKRAWEWKDEFGGKISNQLKQLGDSCDWDKERFTMDEGCNEAVIE
                     FFVSLYEKGHIYRGNRIINWCPDCKTTLSDAEVEHEEHDGNFYHIKYPLKDSEDFLEI
                     ATTRPETMIGDTGIAVNPEDDRYKHLIGKTAILPLVGRELPIVADSYVDLEFGTGAVK
                     MTPAHDPNDFEVGLRHNLEQLNTMNEDGTMNEVCGKYEGMDRFECRKAIVADLKEQGY
                     LIKIKEHNHNVGTCYRCHTVVEPRLSEQWFVKMEELAKPAIDILKKGELEFVPDKFDK
                     TYLQWLENIRDWCISRQLWWGHQIPAYYCQECGEIVVARKMPDKCPKCGSTHFKQDED
                     ALDTWFSSALWPFSTLGWPNKTEALDYYYPTSVLVTGYDIIFFWVVRMAFAGMFCMNE
                     KPFDHVLVHGLVRDSQGRKMSKSLGNGIDPLEIIEQYGADALRFTLTTGNSPGNDMRF
                     YMERVEFARNFANKLWNASRFVFMNIDEDIIKNMTRESVKEDLTLADKWIISRANNIV
                     KEATNNMDKFDLGIALQKIYDFTWSEYCDWYIEMVKPRLYGEDANAKSAALYTLTYVL
                     EKILKLLHPYMPFITEEIYTHLPTVEGCIIVSEWPKYNEEDNMAEEEDMMNLLMEGIR
                     SIRNVRAEMNVPPSKKAKLIIIPSEEKIEAIELGKDYFITLASASNVEIAKDKSNVPE
                     DAVGVVIDGVEIFIPLNELVDFEKEIERLSKEKKKLEGEIKRVNGKLANQGFLAKAPE
                     SLIEEEKAKKEKFEEMIKSVEERLTNLESKIK"
BASE COUNT         5038 a         1308 c         2292 g         3865 t
ORIGIN      
        1 ttcaacaaga ttgtttgaaa attaaataaa tttgtagatg tgaataatat tttttatata
       61 taaaaacaaa ctaaaacagt agaatatatg gtaaaaatta cctatagttt ttgttctaaa
      121 aagctcctat tattaattta agttagacga attaaggaag tgacataaat ggagcgacaa
      181 gaggtagaaa gtaaattacg caggggcgaa ttaatgttga tggagtacat gtgaagggaa
      241 aagtctactc tatctaaaaa agaaatagaa gtagcaatga aagaaaagta taagtggaga
      301 aaaagcacta cagagatttt acttggaaga ttagtaaaaa tgagaatatt aaaaaagaag
      361 agagttggtt ttcaattaaa ctatgaagta ttagtaacta aaaaagaata tttagatgta
      421 ataaaagaag aaaaagatgt aagtaaatat gataattttt ttacacaagt atttacaact
      481 atacataaaa aagaagaaaa gacagagaaa caaataaaag tatttataga aagtatgcag
      541 aaactaggaa aaaaataatt ttatattttt atatgttaat agaaagaagg ggatattatg
      601 ctaaataaaa aattaccaga ttcagagttc aagattatga aatacatatg gaatactggt
      661 tataaaactg taatatcaaa agatgtggca gatgaaatgg aaaaaatata taaatggaaa
      721 caaactacaa cactaacact tttattaagg ttaactaaaa gaggtttttt agcttctcaa
      781 aaaataggta aacacacaca ttatacaata ttaataaaag aaaaagaata cttaaaatca
      841 gaaactaaaa aactatttgg aggtttacat aataatcctt tatcacagtt aatatcaaaa
      901 ttacatgata aagaagaggt aagtattgat aaaatagatg cgcttgaaga atggttaaga
      961 agtttgcaag aagatgaaga ataagaatat gccaaaaggt agcactcaat agtagctacc
     1021 tttttgtgga taaagctggg gataaactgt ggaaaagtta tataaaaatt gtggataaaa
     1081 tgttttgctg acatttaact gacataaata ttaaaacttg attttaaagt attgaaattt
     1141 caattattaa tcatataaaa atagaaaagt tattatttta ataaggaata ataaatatat
     1201 taatatcatt aataattgtt ataaatgtga aatgctaacg atatctaaac taaattatta
     1261 taaaatagct gactgtaatt taattgataa agcctattct tctagacttt gccagttaaa
     1321 ttacagtcag ttttattata taaaaaaatg cgtaacggaa ctattatttt atagattata
     1381 tttgaaaaga taaataaatt gtatatctaa atttatatat tattttttac ctttaatata
     1441 tattaaataa taaaatagtt aaataataag attaagaatt tcttaataaa tccagaagat
     1501 gctttcgatt atataatatt ttatattttt atattattaa ttatatatgt tgcaattgct
     1561 gcacctactt tttctggtga gtatcagaca caatcagata gcatccttcg ttgtacgaaa
     1621 catggacata ttcgtctagc gtttactaaa atattagctc tattttctat atttataata
     1681 atgtttgtta tatgtatttc tatccatttg gcaatttctg atttagcttt tggtactgaa
     1741 tgtttgaaaa cctcatttca aatgttgttt tctgtcatta gtctagtaaa tataaattta
     1801 ctacaagcac agattcttat agctattggt ggtctaattt caatacttgc aatggttagt
     1861 ttaacattat ttttatctgc aaaatgtaag gattctctta cttctatgca gattgctttt
     1921 tctatttgct taattcctat gggaataggt gttagttgga ttggatacct attaccacca
     1981 gggggaattg gttttaagat tagtttatta tatcaaatga catcatttaa tttcttacac
     2041 ttaggaggta tgagtttttg gacaccacac attatactgt ttttctcagt gatagaaata
     2101 cctattttta tatttttggc tattcgtacc tattgcaaac atcaagtatc gtaacaattt
     2161 gatggaaata atagtgatat aaactagagg atacaataat tatatatgta gtataaaagt
     2221 taaatttagt taacaaatct taatagcaga tataggtaat aaattataca taaactgtat
     2281 tattatctat atctgctatt ttaatataga gaaacaacag tatattgtaa agtaaatgtc
     2341 aaatatagtt ttaaaagtaa aattaatgtt aaaaagtaaa tataatttta cacttgctta
     2401 acttaatcct aatatagatt taacttaaaa aaagtagaat aaaagtatag gaaatttgat
     2461 gaagacgaat tataaaaaat taaattttga atacagaacg aaaatcgata agtatatttt
     2521 aatgggaggg tattatgata gtaaaatcta gattagtagg tttagaaaaa aatgacaata
     2581 atggaaataa gacaaaatac gtaattgaaa aagtagcaaa aaatattttt ctacttagtg
     2641 ctttagtagc agttgcaagt ttacttttga taataggatt cgtattttat aaaggattaa
     2701 gaccatttat atttgaagga tattcattta tagacttttt aactggtgca gattgggttc
     2761 cttctgccaa taaatttgga atatcatcta tgatagtagc atcaatattt gcaacacttg
     2821 gagcacttgt tataggagta cctgttggta tattaacctc tgtatttata gcagaagtag
     2881 cacctaaaag attagcaaaa ataatgtcac cagcagttga acttttagca ggtatacctt
     2941 cagtattata tggtgtattt ggtcttgcag tgatagttcc aactatacaa agtatattta
     3001 atcttccaaa aggtcaaagt ttgttagcaa tagtaatagt attagcagta atgatgttac
     3061 caacaataat atctgtatca gaaacagcaa taagagcagt accaaaagca tacaaagaag
     3121 gttcattagc acttggtgca tcaaaaatag aaacaatatt caaagttgta ttacctgctg
     3181 caaaatctgg agtattagcc gcagtagtgt taggagtagg aagagcttta ggtgaaacaa
     3241 tggcagtaat acttgttgca ggcaactcac cagttatgcc aactgcaata acagatagtg
     3301 taagaccact tacaactaat atagcacttg aaatgggata cgcatttggt acacatcaag
     3361 aaatgctatt tgcaactgga gtagtattgt ttacatttat attaatttta aacttagttt
     3421 taaataaact ttcaaataag gcggtaaatt aagatgagaa agttcaaaga gaatctattg
     3481 aagtcattag tatatctatc agcactattt acaatagtat cattagtagt tatagtggga
     3541 tttatattta taaagggaat tggcaacatg aattttaatt tcttatttag caattattca
     3601 gcatcaggtg atggtggtat acttccaatg ataattacaa cattatatac agtagtagtt
     3661 tctatagttg tagcaactcc tataggaata ttggctgcta tatatttaca agaatatgct
     3721 aaaaaaggaa aagcagttac agctataaga tttgcaactg aaagtttatc agggatacca
     3781 tctatagtat atggattatt tggaggaatt ttctttgtag ttacattaaa aatgggatat
     3841 tccatagttg caggttcact tacagttgca ataataatat taccagtaat aattcgtaca
     3901 acagaagaag ctttaaaaac agttcctcaa gcttatagag aatcatcatt ggcattagga
     3961 gctacaaaat ttcaaacttt atataaggta gtacttccaa gtgcaatacc aggaatttta
     4021 tctggagtaa tcttatcagt tggtcgtata attggagaat cagctgcaat attacttaca
     4081 gcaggtactg tagccaagat gccaggtgga atatttgata gtgcaagaac attaactgta
     4141 cactcatact tactgactaa agagagtgga gatatagcaa cagcagccag tataggaatt
     4201 gttttaatag taattgtgtt agcactaaac atgctagcaa gatttgttgc taagaaatta
     4261 aataaagcta attattaaat ttaagaggtg tgaataatgg aattaatcga taagataaaa
     4321 atgagtgtaa aagatttgga tttattttat ggtgataagc aagcattaaa gaaaataaat
     4381 atggatataa aagagaataa ggttactgct ttaataggtc catctggatg cggaaaatca
     4441 acttttataa gaacgttaaa tagaatgaat gacttaatcg aagatgtaac aattaaagga
     4501 aacatttctg ttgatggaga ggacatatat acctcagatg atgttataaa tcttcgtact
     4561 aaagtaggaa tggtatttca aaagccaaat ccatttccta tgagtatata tgataatgtg
     4621 gcatatggtc ctcgtacaca tggactaaga gataagaagc aattagataa aattgtagaa
     4681 gaaagcttaa aaggtgcagc tatttgggat gaggttaaag acaggcttaa atcatctgca
     4741 ctaggacttt ctggtggtca acaacagcgt atatgtatag caagagcaat tgctatgaga
     4801 ccagaagtta ttcttatgga tgaacctaca tctgctttag acccaatttc aacattaaaa
     4861 gtagaggaac ttatagagga tttaaaaaaa gactacacaa tagtcatagt tacacataat
     4921 atgcaacaag ctgctcgtat atcagatgaa acagcttttt tcttaaatgg agaggttata
     4981 gaatttagcg atacaaaaac tatgtttacc actcctgtag ataaaagaac agaagactat
     5041 ataacaggta gatttggtta aaatatataa ctataaagga gttagacaat ggtcaataat
     5101 agcttagata taagtattga tactttaaaa gaacaaacag tgcttatgat ggaaaaatgt
     5161 gaagaagcaa tagaaaagtc tgtgacttgt atgatagaga aggatttaga gggtgcaaga
     5221 aaagtagtag aagatgatga agaaataaat aaattaagag aagaaataag agataagagt
     5281 atagagctaa tagtattaaa gcaaccaatg gcaagggact taagatttat ttattcatta
     5341 ggtaatatat ctatagagct ggaaagaata ggagattatg cagcaaatat agctagagaa
     5401 atgttgaaga taggtggaga ggcttatata aaagagctaa tagatattcc taagatggca
     5461 aaagaatgta agtctatgat gtctcagact agagaagctt taatcttatt tgatgcaagt
     5521 atagcttatg atgttggaac taaagatgat attgtagatg gattgtatga acaagtacaa
     5581 attgattgtt taaaaataat gcatgaaaac tcaaatacca tagaccaagg ggtaaaactt
     5641 ctacttatag gaagatacct tgaaagaatt ggagaccata taacaaatgt atgtgagaag
     5701 ataatttttg caattgaggg taaaatggtt gagataggat aaaaaactgc tttaaagcag
     5761 tttttttatt gtctaaatta agaaagaatt gataaaaaaa tatgattaat gggtaaattt
     5821 aaaaaattgt gatatactag gaacatatta aatatgagga tgcgtatttt atataaggtg
     5881 ctttttagga ggtggaactt tgaaacttca aaagatgggt atgaggacta taaaaacagg
     5941 aattagtgtc actttatgta tgattcttgg tgactattta gtagagaata tgttttattc
     6001 tctggtagca tgtataattt ctgttcaaga tacagtaaaa ggttctttaa agacgggaat
     6061 caatagagtg gaaggtacta ttttaggtgg tataatagga ttcatatttg ccatcattaa
     6121 agctggagac ccatttttat gtggtctagg agtaatgtgc tcaatatatt tatgcaatct
     6181 gtttaaaata aagtcagtag tagttgcctg tgtaaccttt ctggctatac atctaggtgt
     6241 aggaaatagt gaccctgtat attattcttt acatagggtg ttagatacat ctgtgggtgt
     6301 tttgtttgga gtacttgtta attattatgt tgctagacca aattatctaa atagtgttat
     6361 agatgagttt aaaaagatag aagaactttc aatgttgctt attgaagata aaattcttag
     6421 aaaagaaaat ttaaatgtag agaaatttga agaagaagta gaaaaattag aagaaatata
     6481 ttcaaagctt attgatgagt tggattatag tttgagtgaa actaatatag aaaaaattga
     6541 gaatgcctta aggatatgta gagaaataca ttttcatatg cagtctatag agttacttga
     6601 aaataaactt tatttgaaag agcatacata taaatacctt aagaaaacat ataatgtgga
     6661 taagctagac tggaatatag atgaagaaaa aagccctgta ttcaactatc atctaatgaa
     6721 aataatgatt gaaatagagt tgttgagaaa gctaaataaa tcatattaat aatagtagtt
     6781 aaataataaa taaaaaatag tatctttgta aatattaaac atatataagt ttaatttatg
     6841 gaggtactat tttttatgaa tactagaaat gacaattcta aaatactaga aatatataaa
     6901 atgaagcttt ttggcgaact tgtaaaagca gtgtggaatg atgatataga ggatattgaa
     6961 aacttaccta ataaaatttt aaatgaagat ttaaaggata atttaaataa ttattttagt
     7021 ggaaaatttg ataaagatac tatggtaaat ttaattaggg taactatggg attggatgtg
     7081 acagaagata cagataaaaa tttaaaagag tcactacatg aagctgtaaa tttagatgaa
     7141 gtcaaaagac caataatatc tgtaatatca gatgcttgca aatattgtga tgaaaataat
     7201 aaggaagatg agtcatgtaa gataagaagt aagcatatta attgtaatga ggaagatgta
     7261 tgtagtgctt gtggtgattg tgtatcaaga tgtaagttgg gtgcaatttc agataaaata
     7321 gaatttatac caatgataaa attgttaaaa gatataaaga gccctgtata tgcaatagtt
     7381 gcaccagctt ttgtaggaca atttgggaaa gatgtaagcc ctggtaaatt aagaactgca
     7441 ttaaaaaaga taggatttga agatatgata gaagttgctt tggcagcaga tatgcttact
     7501 gcaaaagaag catatgatta ttatgagcat atgaaaaagg acgaagaagg atgctttata
     7561 actagttgtt gctgtcctat ttgggttagt ttgatacaaa atagttttcc tcagatattg
     7621 gaaaatgtat caccatccgt ttctcctatg attgcttgtg ggagagctgt aaaaatttta
     7681 aatccagatg ctaaagttgt attcataggt ccttgtatgg caaaaaagaa agaggcaatg
     7741 ttagaagata taaaagatgc agttgatttt gtgcttacat ttaaagagtt gcaagaaata
     7801 tttgatgcat tagagttaaa tccagcaata atggatgaga gtaatagagt agaggcgtcc
     7861 ctttcaggta gagtttatgc tagaacagga ggtgtaagta aagcagttaa gttatcagtt
     7921 agaagaattg acaaaaatat aaaatttgaa gaaaaggcat ttgaaggaac aaaagagtgc
     7981 atggacggtc taaagaaagt tctaaataaa gaaatagaag ctacatttat agaaggaatg
     8041 gggtgtgtag gaggctgtgt aggaggtccg aagcgtattt taagtgtgga agaaggtact
     8101 aagaatgttg atgaatatag tgaaagtacg aatatggaaa ctccatttga taatttaaat
     8161 gtattacaat ttttaacttc tttgggaatc aaaagagtag aatctttagg agaaaaagaa
     8221 gaagaaaagg ttaaaaaaat atttagtaga gatataaaaa gtaataagaa agagaataaa
     8281 tataaaaaat aactttttaa gtcttaaact tatgctttta taaaagggag atatggggga
     8341 tgaaaattaa agataataag gctgtttttc atgtatttat aaggatattt cttatagctg
     8401 ttttaatttt aactggaaca ttattggagg aaaaaattaa taatgttcca gttgaaaata
     8461 taagttcaaa aggtgaaaat acactggaac tgctttctca aagtaatact ttaggagaaa
     8521 tcatatacaa agcatctcaa gaagaaacaa aaggtccagg ggctacttct gaaaaagtag
     8581 catacataac aatagatgat ggtccatcaa aatatacaaa tgcactactt gatattttaa
     8641 aagaaaatga tgtcaaagcg acatttttca tgcttaatca gaatatgaaa aaccacaagg
     8701 aagaagtaag gagagtcttg gaagaagaaa actcaatagg ttttcatagt gtaagtcatg
     8761 atatacataa gttatataaa agcccagaag taacagttgg ggaatttaat acatgcaata
     8821 atactctaca agaaataact ggtcagagtt caaaattaat aagattacca tacggaagta
     8881 aaccatatat gccagaaggt tcatataata aacttatggc aaatgattat ttaatttggg
     8941 actggaattt ggatacacag gattggaagt cttctacaag tcagatagta agtaatatat
     9001 tatattatgg aagaaaaaga gatgaattag tagtattaat tcatgagaaa gagcaaagtt
     9061 taaatgcttt aaataatatt ataagaatct taaaagagag aggatataca atattgccaa
     9121 ttacagaaaa tataacacct aaaaatttct ggcaagaaaa cttataataa atttaaatat
     9181 agtaaaagat aaagtaaatt atttataaaa taaaacatat aatataaaaa atacgaataa
     9241 gaggtatact gtaaggataa tataaaatta atgagaaagc attaaaatta aaataatctt
     9301 gcaattattg acattataag acagaataac tgtaaaaaca tattttaaaa tataacaact
     9361 atataaaaga gaatagacat aattaagaaa attcagaaaa aataaaataa aaataattga
     9421 caaagagaat aatatttgta tataataata tgtaatatta aagactgaga agaagaggag
     9481 taagtaaata ctactaaaag agaggaaaat tcactggctg taagattttc taagtataag
     9541 atttactgaa tgtagctttg gagtttctaa actgaactat aagtaagttt agacggttag
     9601 aaccgttaaa ttctttgaga gtcaaagttg ataaaataac attaaccaat aatttaatta
     9661 tatgttaatg tattttaagc tttggaatta aggtggtaac gcgagctttt cgtccttttt
     9721 aaagaggatg aagagctctt ttttatttct aaagatattt aaaaaattta tttataaaat
     9781 acaggaggca ggacaatgga aaatacgaat ttatcaaaaa cttataaccc aaaagatttt
     9841 gaggctaggc tatataaaaa atggatggat gaagggtatt ttaaatctaa accaaatcca
     9901 gataaaaaac catttacaat aatgatgcca ccaccaaata taacagggca attgcatatg
     9961 ggacacgctc ttgaccatac acttcaagat atattaatca gatggaaacg tatggatgga
    10021 tatgaagctt tttggcttcc aggaactgac catgcttcta tagcaacaga agttaaagtt
    10081 gttgaaagaa taaaaaaaca agaaggcaag acaaagtatg aaataggtag agaagaattt
    10141 ttaaagagag cctgggaatg gaaagatgaa tttggaggaa aaatatctaa tcagcttaaa
    10201 caactaggtg attcttgtga ttgggataaa gaaagattta ctatggatga agggtgtaat
    10261 gaagcagtta tagaattttt tgtaagccta tatgaaaaag gtcacatata cagaggaaat
    10321 agaataataa actggtgccc agattgcaaa actactttat cagatgcaga agttgaacat
    10381 gaagaacacg acggaaactt ttatcatata aagtacccac taaaagatag tgaagacttt
    10441 ttagaaatag ctacaactag acctgagaca atgataggag atactggtat agcagtaaat
    10501 ccagaagatg atagatataa acatttaata ggaaaaacag caatacttcc attagtagga
    10561 agagaacttc caatagttgc agatagttat gttgatttag agtttggaac tggtgcagtt
    10621 aagatgactc cagcacatga ccctaatgat tttgaagtag gattaagaca taatcttgag
    10681 cagttaaata ctatgaatga agatggaact atgaatgaag tttgtggaaa atatgaaggt
    10741 atggatagat ttgagtgtag aaaagctatc gtagcagact taaaagaaca aggttaccta
    10801 attaagataa aagagcataa tcataatgta ggaacttgtt atagatgcca tacagtagtt
    10861 gagcctagat tatcagagca atggtttgtt aagatggaag aacttgcaaa accagctata
    10921 gatattctta aaaaaggaga attagaattt gttccagata aatttgataa aacttattta
    10981 caatggctag aaaatataag agattggtgt atatcaagac aattatggtg gggtcatcaa
    11041 ataccagctt attattgtca agagtgtgga gaaatagtag ttgctagaaa aatgccagat
    11101 aagtgtccta aatgtggaag cactcatttt aaacaagatg aagatgcctt agatacttgg
    11161 ttcagttctg cattatggcc tttctctact ctaggatggc caaataagac tgaagcttta
    11221 gattattatt atccaacaag tgtacttgtt acaggatacg atataatatt cttctgggta
    11281 gttagaatgg catttgcagg tatgttctgt atgaatgaaa agccatttga ccatgttttg
    11341 gttcatggat tagtaagaga ttctcaaggt agaaaaatga gtaaatcttt aggaaatggt
    11401 atcgacccat tggagataat cgagcaatat ggagctgatg ccctaagatt tacattaaca
    11461 actggaaatt ccccaggaaa tgatatgaga ttctatatgg aaagagtaga atttgctaga
    11521 aactttgcaa ataaattgtg gaatgcatca agatttgtat ttatgaatat tgatgaagat
    11581 ataattaaaa acatgactag agaaagtgtt aaagaggact taactctagc tgataaatgg
    11641 ataatatcaa gagcaaataa tattgtaaaa gaagcaacta ataacatgga taagtttgat
    11701 ttaggaatag cacttcaaaa gatatacgat tttacttggt cagaatactg tgactggtat
    11761 attgaaatgg ttaaacctag attatatggg gaagatgcaa atgctaaatc tgcagcatta
    11821 tatacattaa cttatgttct tgaaaaaata ttaaaattat tacatccata catgccattt
    11881 ataacagagg aaatatatac tcatcttcct actgttgaag gatgtataat agtatctgaa
    11941 tggccaaaat ataatgaaga agataacatg gctgaagaag aagatatgat gaacttattg
    12001 atggaaggta taagaagtat aagaaatgtg agagcagaaa tgaatgtacc accttctaag
    12061 aaagctaaat tgataataat cccaagtgaa gaaaaaatag aagctattga gcttggtaaa
    12121 gactatttta taactttagc atctgcttca aatgtagaga tagcaaaaga taaatctaat
    12181 gttccagaag atgcagttgg agtagttatt gatggtgttg aaatatttat acctcttaat
    12241 gaattagttg attttgaaaa agaaattgag agattatcta aagaaaagaa aaagttagaa
    12301 ggcgaaataa agagagttaa tggaaagctt gcaaatcaag gtttcttagc aaaagctcct
    12361 gaaagtttaa ttgaagaaga aaaagcaaaa aaagaaaaat ttgaagagat gattaaatct
    12421 gttgaggaaa gattaacaaa tttagaatct aaaataaaat aaatataaga attagtaaaa
    12481 acatacaaaa agtatatatt cta
//
LOCUS       DAEQCW010000109        12147 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.110, whole genome shotgun sequence.
ACCESSION   DAEQCW010000109 DAEQCW010000000
VERSION     DAEQCW010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12147)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12147)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12147
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.110"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            151..939
                     /locus_tag="KRO40_002968"
     CDS             151..939
                     /locus_tag="KRO40_002968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH2093777.1"
                     /translation="MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAN
                     EVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKKEGKIDILVNNFGSTNPSLDKDL
                     VTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV
                     SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIG
                     EPDDIAKAVLFYASDDSSFITGDLLEVAGGFGLPTPQFADNILG"
     gene            1410..5126
                     /gene="rpoB"
                     /locus_tag="KRO40_002969"
     CDS             1410..5126
                     /gene="rpoB"
                     /locus_tag="KRO40_002969"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HBH2093778.1"
                     /translation="MPHPVTIGKRTRMSFSKIKEIADVPNLIEIQVDSYEWFLKEGLK
                     EVFDDISPIEDYTGNLILEFVDYSLDDKPKYDIEECKERDATYCAPLKVKVRLINKET
                     GEIKEQEVFMGDFPLMTERGTFVINGAERVIVSQLVRSPGVYYAEERDKTGKRLISST
                     VIPNRGAWLEYETDSNDVISVRVDRTRKQPVTVLLRALGIGTDAEIIDLLGEDERLSA
                     TLEKDNTKTVEEGLVEIYKKLRPGEPPTVESASSLLNALFFDPKRYDLAKVGRYKFNK
                     KLALCYRIMNKISAEDIINPETGEVFVKAGEKISYDLAKAIQNAGINVVNLLMDDDKK
                     VRVIGNNFVDIKSHIDFDIDDLNIKEKVHYPTLKEILDGYSDEEEIKEAIKSRIKELI
                     PKHILLDDIIASISYEFNIFYNIGNIDDIDHLGNRRIRSVGELLQNQVRIGLSRMERV
                     IKERMTVQDMEAITPQALVNIRPVSAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSA
                     LGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLGTYAKINEFGFIESP
                     YRKFDKETSTVTDEIHYLTADEEDLFVRAQANEPLTEDGKFVNHRVVCRTVNGAVEMV
                     PESRVDYMDISPKQVVSVATAMIPFLENDDANRALMGANMQRQAVPLVRREAPIIGTG
                     IEYRAAKDSGAVVVARNSGIAERVTADEIIIKREDGNRDRYNLLKFKRSNSGTCINQT
                     PIINKGDQIIKGDVIADGPATDLGEVALGRNCLIAFMTWEGYNYEDAILINERLVKED
                     RLSTIHIEEYECEARDTKLGPEEITRDIPNVGDSAIKNLDDRGIIRIGAEVDSGDILV
                     GKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDDL
                     SPGVNELVRCYIAKKRKIKVGDKMAGRHGNKGVISRVLPEEDMPFMENGTPLDIILNP
                     QGIPSRMNIGQVLEVHLGLAAKTLGWYVATSVFDGANEYDIMDALEEAGYPRDGKLTL
                     YDGRTGESFDNRITVGYMYYLKLHHLVDEKLHARSTGPYSLVTQQPLGGKAQFGGQRF
                     GEMEVWALEAYGAAHILQEILTVKSDDVVGRVRTYEAIVKGENIPEPGIPESFKVLIK
                     ELQSLCLDVKVLTDEDQEIEVRESVDEDDTIGEFELDVVNHMGEVEESNIIEEIEDDF
                     AENAEDEDIENLEEFTEDDLFEEEIDFDSDDFDM"
     gene            5168..8653
                     /gene="rpoC"
                     /locus_tag="KRO40_002970"
     CDS             5168..8653
                     /gene="rpoC"
                     /locus_tag="KRO40_002970"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HBH2093779.1"
                     /translation="MFELNNFESIKIALASPEKIRQWSRGEVKKPETINYRTLKPEKD
                     GLFCERIFGPQKDWECHCGKYRRVRYKGVVCDRCGVEVTKSKVRRERMGHIELAAPMS
                     HIWYFKGIPSRMGLLLDMSPRSLEKILYFASYVVVDPGETGLNEKQLLTEKEYRTALE
                     KYGYTFTVGMGAEAVKTLLQNIDLEQQSKDLRAELKDSTGQKKVRTIRRLEVVEAFKK
                     SGNKPEWMILDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLELGA
                     PDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGK
                     RVDYSGRSVIVVGPELKFYQCGLPKKMALELFKPFVMDKLVKEGYAHNIKSAKSIVEK
                     VKPEVWDVLEDVIKSHPVLLNRAPTLHRLGIQAFEPILVEGKAIKLHPLVCTAYNADF
                     DGDQMAVHVPLSVEAQAEARFLMLSVNNILAPKDGSPITTPSQDMVLGCYYLTIEAQD
                     GAKGTGMVFKDFNELLLAYYNKSVHLHALVKLKVTLEDGRSSLVESTVGRFIFNENIP
                     QDLGFVDRKENPFALEVDFLADKKSLGKIIDKCFRKHGNTETAELLDYIKALGFKYST
                     LGGITVAVDDMSVPEEKKVFIAEAEAKVDKYEKAYRRGLISDEERYEKVIETWTETTD
                     KVTDALMGGLDRLNNIYIMAHSGARGSKNQIRQLAGMRGLMANASGKTVEIPVKSNFR
                     EGLSVLEYFTSSHGARKGLADTAIRTAESGYLTRRLVDVSQDVIVREIDCGTEDTTEI
                     YAIKEGNEVIEEIYDRIVGRYTIDPILNPETGEVIVEADSMIQEDEAETIVALGIEKI
                     RIRTVLNCKTNHGVCSKCYGRNLATGKEVNIGEAVGIIAAQSIGEPGTQLTMRTFHTG
                     GVAGADITQGLPRVEELFEARKPKGLAVITEVSGRVEIDETGKRKEVNVIPEEGETQT
                     YVIPYGSRLKVKQGQMLEAGDPLTQGFINPHDIVRVNGVKGVQEYIVKEVQRVYRLQG
                     VDVNDKHIEVIVRQMLSKVKVEDPGDTDLLPGGYEDVLTFNECNKDAIDKGLRPAVAK
                     RVLLGITKASLATDSFLSAASFQETTRVLTEAAIKGKEDHLIGLKENVILGKLIPAGT
                     GMKKYRNIAVEKIED"
     gene            8942..9364
                     /gene="rpsL"
                     /locus_tag="KRO40_002971"
     CDS             8942..9364
                     /gene="rpsL"
                     /locus_tag="KRO40_002971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HBH2093780.1"
                     /translation="MPTINQLVRKSRKALEKKSTAPALQKGYNSLNKKVTDASAPQKR
                     GVCTSVKTVTPKKPNSALRKVARVRLTNGIEVSAYIPGEGHNLQEHSVVLIRGGRVKD
                     LPGVRYHILRGTLDTAGVDKRRQSRSKYGAKRPKEAKK"
     gene            9488..9958
                     /gene="rpsG"
                     /locus_tag="KRO40_002972"
     CDS             9488..9958
                     /gene="rpsG"
                     /locus_tag="KRO40_002972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HBH2093781.1"
                     /translation="MPRKGNIPKREVLPDPMYGSKVVTKLINNLMVDGKKGKSQRIVY
                     DAFAIVAEKTGEEALEVFNKAMDNIMPVLEVKARRVGGANYQVPIEVRPERRQTLGLR
                     WLVKYTRARGEKGMVEKLAKEIMDAANNTGASVKKKEDTHKMAEANKAFAHYRW"
     gene            10007..12073
                     /gene="fusA"
                     /locus_tag="KRO40_002973"
     CDS             10007..12073
                     /gene="fusA"
                     /locus_tag="KRO40_002973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBH2093782.1"
                     /translation="MARKFPLERTRNIGIMAHIDAGKTTTTERILFYTGQTHKIGETH
                     EGASQMDWMEQEKERGITITSAATTASWKDHRINIIDTPGHVDFTVEVERSLRVLDGS
                     VAVFCAKGGVEPQSENVWRQAETYGVPRIAFVNKMDILGADFYNVVSMMKSRLNSNAV
                     PMQLPIGKEDSFIGIIDLLKMDAVIYKDDLGVEMEETDIPEDMKELAAEWREKLVESV
                     AETDEELMMKYLEGEELTIDELKVAIRKATIACEMNPVFCGTAYRNKGVQLVIDAVLD
                     YLPAPTDIPAIKGILADGEEAERHSSDEEPFSALAFKIMTDPFVGKLAFFRVYSGTLE
                     SGSYVLNATKNKRERIGRILQMHANTREEITKVYAGDIAAAVGLKDTTTGDTLCDPAN
                     PIILESMEFPEPVISVAIEPSSKAAQEKMGIALQKLAEEDPTFTVKTDQETGQTIISG
                     MGELHLEIIVDRLLREFKVEAKVGAPQVAYRETITQPVDVEYKYSKQSGGRGQYGHVK
                     IRVAPQEPGEGYKFTNKTVGGSVPKEYVGPVDMGIQGAMQSGIVAGYPVVDVAVELYD
                     GSYHEVDSSEMAFKMAGSMAFKDAMKKGNAVLLEPYFKVEVVTPEDYMGDVMGDLNSR
                     RGLIQGMEARSGAQVINAFVPLSEMFGYSTDLRSSTQGRATYTMIFDHYEQVPASVAK
                     KIAEGK"
BASE COUNT         4701 a         1532 c         2499 g         3415 t
ORIGIN      
        1 ttacatttta gtttaaaaaa atacacgagt gttttgtaaa taaaatgtaa taaataatta
       61 attaacaaat ataaatttta aaataagtta gatatttaga aaaatcgaaa tttgtaggat
      121 ttaaaggaca tattcaagga ggagttaata atggaaaaat tacaaggaaa aattgcagta
      181 gttactgcag caacaaaagg tattggatta gcatcagcag agatattagc aaaaaatgga
      241 gcaactgtgt acttagcagc tcgttcagaa gaattagcta atgaagttat aaataaaata
      301 agtgcagaag gtggttgtgc taagtttgtt tactttaatg ctcgtgaaga agagaccttt
      361 acctcaatga tagaagaggt agttaaaaaa gaaggtaaga tagatatact tgtaaacaat
      421 tttggttcaa caaacccttc tcttgacaaa gaccttgtaa ctggggatac agataatttc
      481 tttgacacag taaatactaa tttaaaaagt gtgtatttac catgtaaagc agcaattcct
      541 catatgataa agaatggaaa aggaagtata gtaaatatat caagtatagg ttcagtatta
      601 cctgatttat ctagaatagc ttactgtgta tcaaaagcag caatcaactc attaactcaa
      661 aacatagcta cacaatatgc taaagacaat gttagatgta atgctgtact tccagggctt
      721 attgcaacta aagcagcatt agacaatatg tctccagagt tcataaaaga atttttaaag
      781 catgttcctt taaatcgtat aggggaacca gatgatatag caaaagctgt tctattctat
      841 gctagtgatg actcatcatt tataacaggg gatttacttg aagttgcagg aggatttggt
      901 ttacctactc cacaatttgc agataatata ttaggataat taaattacta atatgcaatg
      961 aaagcttatg cattagttgt agtagaaatg atatttttat aaagaccata gatataattt
     1021 atattggaaa ggtttgaggt tcaaaattcc aagttaaatt tatttatggt ctttattttg
     1081 tatattttaa taaattgtat atatttgtat aaatgtaatt atttacaatc attttaatat
     1141 ggaattataa ttaaataggg gggatggtac ttgtataaaa ttttttatag aaaattagac
     1201 ctataaatga aaaatatgga ttttatattg gaaaattgta cataatacat aatatatgct
     1261 taaaataatt tacaaaaaat caaaaataat gcatagttta catataagat aaaaaatata
     1321 ttgaaaaata cttgacatta tgctaaaatt attagatgcg ttagaatgaa ctattgtttt
     1381 atttttaatt attgagaggt gaaaagtgaa tgccacatcc tgtcacgata ggtaaaagaa
     1441 ctagaatgag cttttctaaa attaaggaaa tagctgatgt gccaaatctt atagaaattc
     1501 aagtagattc ctatgagtgg tttttaaaag aaggtttaaa agaagtgttt gatgatattt
     1561 caccaataga agattatact ggtaatctta tattggaatt tgtcgactat tctctagatg
     1621 ataaaccaaa gtacgatata gaagagtgta aagagagaga tgctacatat tgtgcacctc
     1681 taaaggttaa ggtaagactt ataaataaag aaacaggtga gataaaagaa caagaagtgt
     1741 ttatgggtga cttcccttta atgacagaaa gaggaacttt cgttataaat ggagcagaaa
     1801 gagttatagt aagtcaatta gttagatctc ctggtgttta ctatgcggaa gaaagagata
     1861 aaacaggtaa gagattgatt tcatctactg taattcctaa tagaggagca tggttagaat
     1921 atgaaacaga ttctaatgat gtaatatctg taagagttga tagaacaaga aaacaaccag
     1981 ttacagtttt acttagagct ttaggaatag gaacagatgc agagataatt gaccttttag
     2041 gagaagatga gagattatct gctacattag aaaaagataa tactaagaca gtagaagaag
     2101 gtcttgtaga gatatacaaa aaattaagac caggtgaacc tcctactgta gaaagtgcat
     2161 catctttatt aaatgcttta ttctttgacc caaaaagata tgacctagca aaagttggta
     2221 gatataaatt caataagaaa cttgctttat gttatagaat aatgaataaa atttcagcag
     2281 aagacataat aaatccagaa actggagaag tatttgtaaa agctggagaa aaaataagct
     2341 atgatttggc taaagccata caaaatgcag gtataaatgt agtaaatcta ctaatggatg
     2401 atgataaaaa agttagagtt ataggaaata attttgtgga tattaagtct cacattgatt
     2461 ttgacataga tgatttaaac ataaaagaaa aagtacatta tccaacttta aaagaaattt
     2521 tagatggata tagtgatgaa gaagaaataa aagaggctat aaaatcaaga attaaagaac
     2581 ttataccaaa acatatatta ttagatgata taatagcttc aataagttat gagttcaata
     2641 tattctataa tataggaaat attgatgata tagatcacct aggaaacaga agaataagat
     2701 ctgtaggtga attgttacaa aatcaagtta gaattggtct ttcaagaatg gaaagagtta
     2761 taaaagaaag aatgacggtt caagatatgg aagctataac gcctcaagcg ttagttaaca
     2821 taagaccagt ttcagctgca ataaaagaat tttttggtag ttctcagtta tctcagttca
     2881 tggatcaaac aaatcctcta tctgagttaa cgcataagag aagattatca gcccttgggc
     2941 ctggaggtct ttcaagagaa agagctggat tcgaagtgcg tgacgttcac cattcacact
     3001 atggtagaat gtgtccaata gagactccag agggaccaaa tatcggtctt ataaactctc
     3061 taggaactta tgcaaaaata aatgaatttg gatttataga atcaccatat agaaaatttg
     3121 ataaagaaac atcaacagtt actgatgaaa tacattattt aactgctgac gaagaagatt
     3181 tattcgtaag agctcaggca aatgagccat taacagaaga tggtaaattc gtaaaccata
     3241 gagttgtttg tagaactgta aatggtgctg ttgaaatggt tcctgaaagt agagtagatt
     3301 acatggatat atctcctaag caggttgtat ctgttgccac tgctatgata cctttcttag
     3361 aaaatgatga tgccaaccgt gcccttatgg gagcgaacat gcagcgtcag gcagtgcctc
     3421 tagttagaag agaagcacca attataggaa ctggtataga atacagagca gcaaaagact
     3481 ctggagcagt tgttgttgct agaaattctg gtatagcaga aagagtaaca gcagatgaaa
     3541 taattataaa aagagaagat ggaaacagag atagatataa tctacttaag tttaaacgtt
     3601 caaactcagg tacttgtata aatcaaacac ctataataaa taagggtgac cagataataa
     3661 aaggtgatgt tatagcagat ggtccagcaa ctgatttagg agaagttgca cttggaagaa
     3721 actgtcttat agcattcatg acttgggaag gttataacta cgaggatgct atattaataa
     3781 atgaaagatt agttaaagaa gatagattat caacaattca tatagaagaa tatgaatgtg
     3841 aagctagaga tacaaaacta gggccagagg aaataactag agatatacct aatgttggag
     3901 atagtgcaat taagaattta gatgacagag gtataataag aataggtgca gaagtagact
     3961 caggtgatat attagttggt aaagtaactc caaaaggaga aactgaactt actgctgagg
     4021 aaagattact tcgtgcaata tttggagaaa aggctagaga agttagagat acttcactta
     4081 aagtgcctca tggtgaatct ggtataatag ttgatgtaaa agtatttact agagaaaatg
     4141 gagatgattt atctccagga gtaaatgaat tagtaagatg ctatatagct aaaaagagaa
     4201 aaataaaagt tggagataaa atggctggtc gtcatggtaa taaaggggtt atctcaagag
     4261 tattacctga agaagatatg ccattcatgg aaaatggaac accactagac ataatactta
     4321 acccacaagg tataccatca cgtatgaaca ttggtcaggt tttagaagtt catttaggac
     4381 ttgctgctaa gacattagga tggtatgtag caacatcagt attcgatggt gctaatgagt
     4441 atgacataat ggatgctctt gaagaagctg ggtatcctag agatggtaaa ttaactttat
     4501 atgatggtag aacaggtgag tcttttgaca acagaataac tgttggatat atgtactact
     4561 tgaaactaca tcacttagta gatgaaaaac tacatgcaag aagtactgga ccatactcat
     4621 tagttactca acagccacta ggtggtaaag cacaatttgg tggacaaaga tttggagaga
     4681 tggaggtttg ggctctggaa gcatatggag ctgctcacat acttcaagaa atacttactg
     4741 ttaagtctga tgacgttgta ggtcgtgtta gaacatatga agctatagtt aaaggtgaaa
     4801 atatacctga accaggaatc ccagaatcat ttaaggttct tataaaagaa cttcaaagtt
     4861 tatgcttaga tgtaaaagta ttgacagatg aagaccaaga aatagaagta agagaatctg
     4921 tggatgaaga tgatacaata ggtgaatttg agctagatgt tgtaaatcat atgggagaag
     4981 ttgaagaaag taatataata gaagaaattg aagatgattt tgcagaaaat gcagaagatg
     5041 aggatataga gaatttagaa gaattcactg aagatgattt atttgaagaa gaaatagatt
     5101 ttgatagtga tgactttgat atgtaaattt aattaatgta aatctcaaat agaagggaga
     5161 gaactccttg tttgaattaa acaatttcga gtcgataaaa atagcattgg cttctccaga
     5221 aaaaataaga caatggtcta ggggagaagt taaaaagcca gaaactataa attaccgtac
     5281 tttaaaacca gaaaaagatg gtcttttctg tgaaagaata tttggaccac aaaaagactg
     5341 ggagtgccac tgtggtaaat atagaagagt tagatataaa ggtgtagttt gtgatagatg
     5401 tggagtagaa gtaactaaat caaaagtaag aagagagaga atgggacata tagagctagc
     5461 ggctcctatg tctcacatct ggtacttcaa aggtatacca agtagaatgg gacttttact
     5521 tgatatgtca ccaagatcgt tagaaaaaat attatacttt gcctcatatg tggtagttga
     5581 tccaggagag actggattaa atgaaaaaca attgcttaca gaaaaagaat acagaactgc
     5641 tcttgaaaag tatggatata cttttactgt aggaatgggt gctgaagctg taaagacatt
     5701 actacaaaat atagatttag agcaacaaag taaagaccta agagcggagt taaaagatag
     5761 tacagggcaa aagaaagtta gaacaataag aagattagaa gttgtagagg catttaaaaa
     5821 gtctggaaat aaaccagaat ggatgatttt agatgcaata ccagtaatac caccagattt
     5881 aagaccaatg gtacaacttg atggtggaag atttgcgact tcagacctaa atgatttata
     5941 tagaagagtt ataaatagaa acaatagact taaaagatta ttagagcttg gagctccaga
     6001 tataattgta agaaatgaaa aaagaatgct tcaagaagct gttgatgcat tgatagataa
     6061 tggtagaaga ggtagacctg taacaggacc tggaaataga ccacttaaat ctttatcaga
     6121 tatgttaaaa ggtaagcaag gtcgtttccg tcaaaactta cttggtaagc gtgttgacta
     6181 ctcaggacgt tctgttatag ttgttggacc agaacttaaa ttttatcaat gtggacttcc
     6241 aaagaagatg gcattagaat tattcaagcc atttgttatg gataaattag ttaaagaagg
     6301 ttatgcacat aatataaaaa gtgcgaaatc tatagtagaa aaagttaagc cagaagtttg
     6361 ggatgtttta gaagatgtta taaaaagtca tccagttctt cttaaccgtg caccgactct
     6421 acatagatta ggtatacaag catttgaacc aatcttagtt gaaggtaagg ctataaaact
     6481 acatcctctt gtatgtacag cttataatgc agactttgat ggtgaccaaa tggcagttca
     6541 tgtaccttta tcagtagaag cacaagcaga agcaagattc ttaatgcttt ctgtaaataa
     6601 tatacttgct cctaaagatg gttcacctat aactactcca tctcaggata tggttttagg
     6661 ttgctattat ctaacaatag aagcccaaga tggagctaaa ggaacaggta tggtatttaa
     6721 agactttaat gaactattac ttgcttatta caataaatca gttcatctac atgcattagt
     6781 gaaacttaag gtaacacttg aagatggaag aagttcattg gttgaaagta ctgttggtag
     6841 atttatattt aatgaaaata tacctcaaga cttaggtttt gtagatagaa aagaaaatcc
     6901 atttgcactt gaagttgatt tcttagcaga taaaaaatct cttggtaaaa taatagataa
     6961 atgctttaga aaacacggaa atacagaaac agctgaatta ctagattata taaaagctct
     7021 aggatttaaa tattctacat taggtggcat aacagttgct gttgatgata tgagtgtccc
     7081 agaagaaaag aaagtattta tagctgaggc agaagctaaa gttgataagt atgaaaaagc
     7141 atacagaaga ggtctaatct ctgatgaaga aagatatgaa aaagttatag agacatggac
     7201 agaaacaact gataaagtta ctgatgctct tatgggtgga ctagatagat taaataatat
     7261 atatataatg gcacattcag gagccagagg ttctaaaaac caaattagac agctggcagg
     7321 tatgcgtggt cttatggcaa atgcatctgg taaaacagtt gagataccag ttaaatctaa
     7381 tttccgtgaa ggtttatcag tactagaata ctttacatct tcacatggtg ccagaaaagg
     7441 tcttgccgat acagctatac gtacagctga atctggatat ttaacaagaa gacttgttga
     7501 tgtaagtcaa gatgttattg taagggaaat agattgtgga acagaagata ctacagagat
     7561 ttatgctata aaagaaggaa atgaagttat agaagagata tatgatagaa ttgtaggaag
     7621 atatactata gaccctatat taaatcctga aactggagaa gttatagttg aggctgattc
     7681 aatgatacaa gaagatgaag cagaaactat agtagcttta ggaattgaaa aaattaggat
     7741 aagaacagtt cttaactgta aaactaatca tggagtttgt tctaagtgtt atggtagaaa
     7801 cttggcaaca ggaaaagaag ttaatatagg tgaagcagtt ggtataatag cagctcaatc
     7861 tatcggtgag ccgggtactc agcttacaat gcgtacattc catactggag gagttgcagg
     7921 agctgatata actcaaggtc taccaagggt tgaagaatta tttgaagcta gaaaaccaaa
     7981 aggattagct gtaataactg aagtatctgg tagagttgaa attgatgaaa caggaaagag
     8041 aaaagaagta aatgtaatac cagaagaagg cgagactcaa acatatgtaa ttccatatgg
     8101 ttctagatta aaagttaagc aaggtcaaat gctagaggct ggagaccctc taacacaagg
     8161 atttataaat cctcatgata tagtaagagt aaatggtgtt aagggagttc aagaatatat
     8221 agttaaagaa gttcaaagag tgtatagact tcaaggggtt gatgttaatg ataagcatat
     8281 agaagttata gtaagacaaa tgctatctaa agtaaaagtt gaagacccag gagatacaga
     8341 tttattgcca ggtggatatg aagatgtatt aacattcaat gaatgtaata aagatgctat
     8401 agataaaggt ctaagaccag cagttgctaa aagagtttta cttggtataa ctaaagcatc
     8461 tcttgcaact gattcattct tatcagcagc ttctttccaa gaaacaacaa gagtattaac
     8521 agaggcagca ataaaaggta aagaagacca cttaatagga cttaaagaaa atgttatatt
     8581 aggtaagtta ataccagcag gaacaggaat gaagaaatat agaaatatag ctgttgaaaa
     8641 aattgaagat taatagcata tagagtaaag aaatcttgac aaccattatt tgtggtgtta
     8701 aaatagtaaa gtgtgttgtt taaaagtaca ctaagggctt gaacaagttc ttagtgactt
     8761 ttagatggca ataaatgaga actaaaaagc atcaagctag aaaagtgcta atatcacata
     8821 tttatgtgtt atagacatta aattgtaagt aacgaatgtt acaatcagtc agtatgaata
     8881 ttcatattga tgtagttggc ggtcactgat aagatcgaaa atttggaagg aggtgcagat
     8941 gatgccaaca attaaccaat tagttcgtaa aagtagaaaa gcgctagaga agaaatctac
     9001 tgctccagca ttacaaaaag gttacaactc tttaaataag aaagtaactg acgctagtgc
     9061 cccacaaaaa agaggggttt gtacttcagt aaaaacagtt actcctaaga agcctaactc
     9121 agctttaaga aaagttgcca gagttagatt aactaatggt atagaagttt ctgcttatat
     9181 accaggagaa ggacacaact tacaagagca tagtgttgtt cttataagag gaggaagagt
     9241 aaaagacctt ccaggggtta gataccatat actaagaggt actctagata cagcaggtgt
     9301 tgataagaga agacaatcaa gatctaaata cggtgcgaag agacctaaag aagctaaaaa
     9361 gtaaaaacaa ttaatgattg attatagttc ggtgctttaa atatatatat atttacggca
     9421 tcacggcatt aaatgattta tgtcgagtac ctatgattta agttaaataa ttaaggaggg
     9481 aagcgaaatg ccaagaaaag gtaatattcc aaaaagagaa gttttaccag atcctatgta
     9541 tgggagtaag gtagttacta aattaataaa taatctaatg gtagacggaa aaaaaggaaa
     9601 gtctcaaaga atagtttatg atgctttcgc aattgttgct gaaaagacag gagaagaagc
     9661 tttagaagta tttaataaag caatggataa tataatgcct gttttagaag taaaagcaag
     9721 aagagttggt ggggcaaact accaagtgcc aatcgaagtt agacctgaaa gaagacaaac
     9781 attaggttta agatggctag taaaatatac tagagctcgt ggagaaaaag gaatggttga
     9841 aaagctagct aaagagataa tggacgcagc taacaacact ggagcttcag ttaagaaaaa
     9901 agaagatact cataaaatgg cagaagctaa taaagcattt gctcattaca gatggtagga
     9961 tatatagata tcttataaaa ttgaggatat cataaggagg ataaccatgg ctagaaagtt
    10021 tcctttggaa agaactagga atataggaat catggctcat atagatgcag gaaaaactac
    10081 tactacagaa agaatcctgt tttatactgg gcaaactcat aaaataggag aaactcatga
    10141 aggagcttct caaatggact ggatggagca agaaaaggaa agaggtataa caataacttc
    10201 tgccgctact actgcttcat ggaaagacca tagaataaac ataatagata ctcctggaca
    10261 cgtggacttc acagttgagg ttgaaagatc tctaagagtt cttgacggtt cagttgctgt
    10321 attctgtgca aaaggtgggg ttgagcctca atcagaaaat gtatggagac aagctgaaac
    10381 ttatggagta cctagaatag cttttgtaaa taaaatggat atattaggtg cagatttcta
    10441 caatgttgta agcatgatga aatctagatt aaattctaat gcagttccta tgcaattacc
    10501 aataggtaaa gaagattcat ttataggtat aatagactta ttaaaaatgg atgctgttat
    10561 atacaaagac gacctagggg ttgaaatgga agaaacagat ataccagaag atatgaaaga
    10621 attagctgct gagtggagag aaaaattagt tgaatcagta gctgaaactg atgaagaatt
    10681 aatgatgaaa taccttgaag gtgaagaact tactatagat gaattaaaag ttgctataag
    10741 aaaagctact atagcttgtg aaatgaaccc agttttctgt ggtacagctt atagaaacaa
    10801 aggtgttcag ttagtaatag atgcagtttt agattactta ccagcgccaa ctgatatacc
    10861 agctataaaa ggtatattag cagatggaga agaagctgaa agacattctt ctgatgaaga
    10921 gccattctct gcattagcat tcaaaataat gactgaccca ttcgttggaa aactagcgtt
    10981 cttcagagtt tattctggaa cattagaatc aggttcttat gttttaaatg caactaagaa
    11041 taagagagaa agaattggtc gtatattaca aatgcatgct aatacaagag aagaaataac
    11101 taaagtgtat gctggagata tagcagcagc agtaggatta aaagatacta ctactggaga
    11161 cacattatgt gaccctgcta atccaataat acttgaatct atggaattcc ctgagccagt
    11221 tatatctgtt gctatagaac caagttctaa agcagctcaa gaaaaaatgg gtatagctct
    11281 tcaaaaatta gctgaagaag acccaacttt cacagttaag actgaccaag aaacaggaca
    11341 aactataata tctggtatgg gtgaattaca cttagagata atagtagata gattattaag
    11401 agaatttaaa gtagaagcta aagttggtgc accacaagtt gcatatagag agactataac
    11461 tcaaccagtt gatgttgaat acaagtactc taagcaatca ggtggtagag gacaatacgg
    11521 tcacgttaag attagagttg ctcctcaaga gccaggtgaa ggatacaaat tcacaaacaa
    11581 aactgttggt ggatcagtac caaaagaata tgttggtcca gttgacatgg gtatacaagg
    11641 agctatgcaa tctggtatag ttgctggata tccagttgta gacgttgctg ttgagttata
    11701 tgatggttct taccatgagg ttgactcttc tgagatggcg tttaagatgg ctggttcaat
    11761 ggcattcaaa gatgctatga agaaaggtaa tgcagttctt ttagagcctt acttcaaagt
    11821 agaagttgtt actccagaag attacatggg agatgttatg ggtgacttaa actcaagaag
    11881 aggattaatc caaggtatgg aagctagaag tggtgcacaa gttataaatg cattcgttcc
    11941 actttcagaa atgtttggat actcaacaga cctaagatct tcaactcaag gtcgtgcaac
    12001 ttacacaatg atattcgatc actatgagca agttccagct tcagttgcta agaaaatagc
    12061 tgaaggaaaa taatttaaaa ataattaata atataaatat aaaaaataat cagctagatg
    12121 agagatatct ctcatctagc acaagat
//
LOCUS       DAEQCW010000110        11608 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.111, whole genome shotgun sequence.
ACCESSION   DAEQCW010000110 DAEQCW010000000
VERSION     DAEQCW010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11608)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11608)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11608
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.111"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            178..1356
                     /locus_tag="KRO40_002974"
     CDS             178..1356
                     /locus_tag="KRO40_002974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2093783.1"
                     /translation="MKYHIFLIITTLLIIELCNIYICKIASFGNKNITIHKNYKYIFL
                     IKPLTFLIIIFTKLPLPLYYILFYIVSHKLLLSRKSSTNNHFIPNMAVISFCILHLIT
                     VSTISLVKNTSPDIIFANMTYKLISILIASILDFILWYSMNKIKEHIYIITQNQIEFS
                     LFLKFIWFTLGYILFDSIQITFAPPSSLTSYFILGSNILLILQLIIFINHIYSIEKNI
                     YLEKEHHRLKMIKQEQLLKVNLLKKKANIDELTSAYNRKFAFEKIQHYIDNNLLFSLI
                     YIDLDKLKTINDTYGHLAGDNYIINFSSIVIENLGIDDIFARIGGDEFIVIMPKSNEN
                     TTKEFIEKISKIMDNKISFSYGIVEVSSENKMTVEEIINIADIRMYTNKQNNHKRNNN
                     "
     gene            1706..2587
                     /locus_tag="KRO40_002975"
     CDS             1706..2587
                     /locus_tag="KRO40_002975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2093784.1"
                     /translation="MPAYLFDSNSITNIYRVFSILLSFIVTGLYFSYKNHKNNKINFE
                     AVLEDKKNLIFLLSLMFGMYLYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAE
                     RYSFRITQIKGYDIKNQIEYVESVKTEYEINKLNDIVYTDLLTGFYNRPFVNQKLSEW
                     TSNHYKFTLCFTDLNSLKPVNDKFGHQFGDKYISTTAQIIKKLINVENSLLFRYGGDE
                     FLFLLQNTSCVEAEKIMININYELSKLSNTDEYPYALSISYGLVEWDGISDIETLISK
                     ADSLMYENKLKNKSTLN"
     gene            2796..2945
                     /locus_tag="KRO40_002976"
     CDS             2796..2945
                     /locus_tag="KRO40_002976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008819224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093785.1"
                     /translation="MTTVAEGIETSFQKDFLQEIDCDMLQGYVFSRPLPIKDFEKLMF
                     QNSSN"
     gene            complement(3205..5772)
                     /locus_tag="KRO40_002977"
     CDS             complement(3205..5772)
                     /locus_tag="KRO40_002977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBH2093786.1"
                     /translation="MIYYVLPLEHKQATIEIVGGKGMSLSKLLTAGIPVPDGFHVTTA
                     SYQIFVETNHIQSRINKLLDGIDSNNTSQLEDVSKKIGELFHNGEMPQEVSDAIKTAY
                     AGLGNISVAVRSSATAEDLPDASFAGQQETYLNIQGEDKVIDAVKRCWASLWTARAIA
                     YRVKNNIKHEIVALAVVVQKLAFSDSSGIMFTLNPINGRRSEMIINAAWGLGEAVVSS
                     LVTPDTIVVDKDSERIISYEVANKEIMTVRTSEGTEETMVPERLRKKYALTRNQVMQL
                     IQLGKKIEKYYQMPMDVEWALEKDKLYIVQARPITVLPPEWVLPEQDVVYTKGSLAEH
                     LPNPVTPLFATLGLEIVNRASELLWIDMFGKSAKKLLPKNGAYTVINGYVYLSAKSKP
                     LLIAIKSLSPRSLRRTLMNSVARWETARKGYEDAIKQWEEKPLHTMNAHQIMEGIQTI
                     FYAACIYFTRIQLTLPAASISETLFTKLFQGAVRRAGITDTSVFLLGFDTIVLQSEKA
                     LWGISEWVKQNNSINLYLQNSSAIKIAEDFMSSVVPVGVSQEVWIEWKNRINKYFKEF
                     GRTAYEFDFAHSTPQETLTPTFESVKTFVEGKGESPFLRQTTFEKRRKHAEEEILQHI
                     GGLRKKLFFKLLHWAQETSPMRENAIYLMGMGHPLIRCMFQKISERFIRGGAISHLDD
                     IYWLTKSELEVLIEQLDKNKSLSDMNGIIPVRKAELKKYMGYVSPSKLPEKNKKTISQ
                     EPQKQKDGKIVLTGIGTSTGVVTAPACVLNSPADFESFQPGSVLVAVTTTPAWTPLFS
                     SASAIVTDIGGPLSHSSIVAREYGIPAVMATHIATRTIKSGQMITVDGLAGTVTFDE"
     gene            complement(5775..6380)
                     /locus_tag="KRO40_002978"
     CDS             complement(5775..6380)
                     /locus_tag="KRO40_002978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002591427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093787.1"
                     /translation="MPKGIVLTPEQQAERREKIVAVALSLMAENGFQKTSMREIAVLA
                     NMGKSSLYDFFKTKDEIVVYAVEKEIEKTIQQVHRIIDGEPSPQQCLRKIMLNHLRFP
                     EQYRTVLMWLNTESDYLEEEYRKRLKDARYAYQDIIKSVIDNGVTTGIFRKTDTALVT
                     RLLINSMLSISYTSRPSDSSEKMLDETMNIFLHGIMNDGGE"
     gene            complement(6754..8214)
                     /locus_tag="KRO40_002979"
     CDS             complement(6754..8214)
                     /locus_tag="KRO40_002979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HBH2093788.1"
                     /translation="MFNELKTKENVYKNLINGKWVESNSRKPIEIYSPIDNSLVGKVQ
                     SMTKHEVDEVIKNTKESIKVWAEMPVYKRANIFHKAADLLLENIDEIANVLVLEIAKD
                     IKSARAEVERTADFLRYTADVGKNMEGEAISGDNFPGGTRNKMSYVSRVPLGTVLAIS
                     PFNYPVNLSMSKIAPALIGGNAVVLKPATQGAISALHVVEIMRKAGIPDGVLNTITGR
                     GSEIGDYVVTHKGINFINFTGSTEVGQHISKISGMVPLLLELGGKDAAIVLEDADLDF
                     AAKNIVSGAYSYSGQRCTAVKRILVQESVADKLVGKIKPLVEKLTIGNPMDEVVITPL
                     IDNKATDFVQGLVDDALHKGAKLITGNVRKNNLFYPTLLDNVNVDMKIAWEEPFGPVL
                     PIIRVKDINQAIEIANQSEYGLQSSVFTSDIDKAFYIADKLEVGTVQINNKTERGPDH
                     FPFLGVKASGMGTQGVKYSIEAMTRPKAVVVNVREL"
     gene            8569..9147
                     /locus_tag="KRO40_002980"
     CDS             8569..9147
                     /locus_tag="KRO40_002980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093789.1"
                     /translation="MAKSFTEIEKDNIRKRLISECELNWSKYGYKKTNIDELCSKSGI
                     AKGSFYTFFDSKEKLFFEVLNGIQNRLISSVDEILSNMPPKEGFAKSLKMLYRLYDKN
                     PFLYSPNNPDFISLINKLPQDMFLQLESNNIQSFYDLIERHNLKLKIEKEKVFGVCNA
                     LLSSLLVKENIEYNYIEVFDFMVDNLVEHILE"
     gene            9438..10688
                     /locus_tag="KRO40_002981"
     CDS             9438..10688
                     /locus_tag="KRO40_002981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093790.1"
                     /translation="MVKSSNTFNKNFNLMILGQIISLFGASILKFALSLYILDITGKA
                     EIFATILAVSSIPIIVFSPIGGAIADIFNRRNLMVIFDFSSSLTVLILAVFLFNNNGS
                     ILLVGIIMTILSVISTMYQPTVQSSTPLLVDNEHLMNANGIVAGVASLTNIAGPVLGG
                     VLYGVIGINAIIVISCVSFFLSAIMEIFIQIPFIKQEQNSNIIKTIFTDIKDGIVHIC
                     KENRFILKILFLAIAINLFLSSMLIVGIPYIVKITMGASNFLYGLAEGAISFSSLVAA
                     VSIGIFSKHLKITNLHISFIICAVMFIPMAVSVYPFILNTGFPVPFLIFIVSSMLIFF
                     TTTLISIYVITVTQLKTPNELLGKVMSILFAGTAIAMPLGQVMYGKLFDLLSDRVYII
                     ILVVGFITLLIAFVSKITLRNENL"
     gene            10849..11418
                     /locus_tag="KRO40_002982"
     CDS             10849..11418
                     /locus_tag="KRO40_002982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBH2093791.1"
                     /translation="MSYMPTLEQAWEILRKYNKEEFHIRHAQIVSGVMRYYAKEYDPE
                     RVEFWEIVGLLHDLDFEMYPDEHCVKQRELMTELDLDKSIIDSTISHGYGLTGSDVKP
                     EQFMEKVLFAVDELTGLIGAAAIMRPSKSVSDLELKSVKKKFKDKSFAAGCSRDVIRS
                     GAEMLGWELDKLIQTTIEAMRSLIPEMAI"
BASE COUNT         4003 a         1916 c         1639 g         4050 t
ORIGIN      
        1 tactgtatat taagatataa tactttctaa attttatata acacagacac atgcaataaa
       61 aaagaaggta tccataataa gctctttgca tgtacctaaa taaaaactgt aaaatagaat
      121 atataaaatc taatctattt taagtaaata caatttcact ttaaaagagg atgtactatg
      181 aaataccata tatttttaat cataactact ttattaataa tcgaactatg taacatttac
      241 atatgcaaaa tagcatcttt tggaaacaaa aatataacta tacataagaa ttacaaatat
      301 atttttttaa taaaaccatt aaccttcttg ataataatat tcacaaaatt accattacca
      361 ctatattata tattgtttta catagtaagt cataaattgc tcttaagcag aaaaagttct
      421 actaacaacc attttattcc caatatggca gtaataagtt tttgtatttt acaccttatt
      481 actgtaagta caatatcact tgttaaaaat acaagtccag atataatatt tgcaaatatg
      541 acctataagt taattagtat tttaatagct tctattttag attttatctt atggtactct
      601 atgaataaaa taaaagagca tatttatata ataactcaaa atcaaataga gttcagtcta
      661 tttttaaaat ttatctggtt cactttagga tatatattat ttgatagtat acaaattaca
      721 tttgctccac caagttctct aacttcctac tttatattgg gaagtaacat attattaatc
      781 ttacaactaa ttatattcat caatcatata tattccattg aaaaaaatat ttatttagaa
      841 aaagaacatc atagactaaa aatgataaaa caagaacaat tactaaaagt aaatttatta
      901 aagaaaaaag ctaacattga tgaattaaca tcagcatata atcgaaaatt tgcttttgaa
      961 aaaatacagc attacattga taacaattta ttattttcat tgatatatat cgatttggat
     1021 aaattaaaga cgataaatga tacatatgga catttagctg gggataacta tattattaac
     1081 ttctcaagta tagttattga aaacttagga atagatgaca tatttgctag aataggagga
     1141 gatgagttta tagttattat gcctaaatct aatgaaaaca ccacaaaaga atttatagag
     1201 aaaataagta aaattatgga taataagata tcttttagct atggtattgt agaagtttct
     1261 agcgaaaaca aaatgactgt agaagaaatt attaatattg ctgatattag aatgtacact
     1321 aataaacaaa ataatcataa aaggaacaat aactaaaatg aatatttaca tgagcttact
     1381 tgtagtctca ctatgttttt tatcttatta tctctatcat tataattttt ttaaatatct
     1441 agacataatg attaataact ctaaaaataa atacaaagta tatattgtat actctctttt
     1501 taattattta atttttatta tttgtactta tttaaggtta cacctagtta taaattggac
     1561 aatttttatg ttaattttat ttatgcaaat taaagtaact tacaaacttt ccacaataaa
     1621 aaaccttttt tattcgttaa actgctccat cattggttta gcaataaata tattttttag
     1681 gtctttaatg tcaatagtgt taaatatgcc agcatattta tttgatagta attctattac
     1741 aaatatttac agagtatttt ctatattgct tagttttata gttacaggat tatatttcag
     1801 ttataaaaat cataaaaata ataagattaa ctttgaggca gttttagagg acaaaaaaaa
     1861 cttaattttc ttattgagcc ttatgtttgg aatgtacttg tatctatgtt tgagtttgtc
     1921 aatatactat actgttggaa atgtattgat tttaaaatta tatggaatca agtctgccat
     1981 aatagttttg gtaggtaact atattgcaga aagatatagc tttagaatta ctcaaataaa
     2041 aggttatgat attaaaaatc aaatagaata tgtagaaagt gtaaagacag agtatgaaat
     2101 taataaattg aatgatattg tatatacaga tttactgaca ggcttctaca atagaccttt
     2161 tgtaaatcaa aaactatcag agtggacatc aaatcactac aaatttacct tatgttttac
     2221 tgatttaaat agcttaaaac ctgtaaatga taaatttgga caccaatttg gtgataaata
     2281 catatccact actgctcaaa taataaaaaa acttataaat gtagaaaatt ccttactatt
     2341 tagatatggt ggagatgaat ttttattcct tttacagaat acaagttgtg tagaagcaga
     2401 aaaaataatg attaatataa attatgaatt atcaaaatta agtaatactg acgagtatcc
     2461 ttatgctctt tccataagct atggattagt tgagtgggat ggaatatccg atattgaaac
     2521 tttaatatca aaggcagatt ctttgatgta tgaaaataag cttaaaaata aatctacttt
     2581 aaactagcta gttaagatat tctacaaaat atatgttata agagagtact aagaatgtca
     2641 aaatatatag attttgcaaa tattgaatac agtttactaa tgaatgcact ggatgtaagt
     2701 gttagtaaac acctattaga tgaacacttt actgttgttt gggctaatga ccgttattat
     2761 gaaatgttcg gctataccta gctaaaaagt taaaaatgac cactgtagcc gagggaatag
     2821 agaccagttt tcaaaaagat ttcttgcaag aaatagactg tgatatgtta caaggatacg
     2881 tgttctctag acctttacca ataaaagact ttgaaaaact tatgtttcaa aactcctcca
     2941 attaacaata taaaattgct tattataagt gatattattg tatcaacaaa taaaggaatt
     3001 gtctcaaaat tgattttttc taatcaaatt tttattttga gacattctca tttttttgca
     3061 taagaaaata cccaccaagc tacggttttt cttaccgctg ttcggtgggt attagtagta
     3121 ttatgaaatc tgaaaacttt aagtattact acttccgcta acgcaatcac aaaggtcgaa
     3181 agcttcaaag cgaaaatagg ctttttactc atcaaacgtc accgtacctg ccaacccgtc
     3241 caccgttatc atttgtccgc tcttaatagt tcgtgtggca atgtgtgtag ccataacggc
     3301 tgggatgcca tattcacgtg cgacaatgct tgaatggcta agaggaccac caatgtccgt
     3361 tacaatcgca cttgcagatg aaaataatgg tgtccatgct ggagttgtgg taactgcaac
     3421 caaaacactt ccaggttgaa agctttcaaa atctgctgga ctattcagta cacaagctgg
     3481 agccgtcaca acaccagtac tggtaccaat gcccgtcaac acaattttcc catctttctg
     3541 cttctgtggt tcttgtgata tagttttttt gtttttctct ggcaacttgg atggtgacac
     3601 ataacccatg tattttttaa gttcagcttt tcgaacaggt attatcccgt tcatatcaga
     3661 tagagacttg tttttatcca actgctctat aagtacctcc aattccgatt ttgtgagcca
     3721 ataaatatca tctaaatgtg aaatagctcc tcctcgtatg aatcgttctg agattttctg
     3781 aaacatacaa cgaatcagag gatgtcccat tcccatcaaa taaatagcat tttcacgcat
     3841 aggagaggtt tcctgtgccc aatggagcaa cttaaaaaat agttttttac gcaatccacc
     3901 tatgtgttgt aaaatctctt cttctgcatg ttttctacgc ttttcaaacg tggtctggcg
     3961 taaaaaagga ctttcccctt ttccttccac aaatgttttt acggattcaa aagttggtgt
     4021 aagtgtttcc tgcggtgtgg aatgcgcaaa atcaaactca taagcggtac gaccaaactc
     4081 tttaaagtac ttattgattc gatttttcca ttctatccat acttcctgtg aaactccaac
     4141 aggcacaact gaagacatga aatcttctgc tatctttatt gcagaactgt tttgcagata
     4201 aaggttgatg ctgttatttt gctttaccca ttctgaaata ccccacaacg ccttttccga
     4261 ttgcagaaca atcgtatcaa acccaagcag gaaaacggaa gtatccgtta taccagcacg
     4321 tcgaactgct ccttgaaata attttgtaaa taatgtttca ctgatagaag cagcaggcaa
     4381 tgtaagctga atccttgtga aataaataca tgcggcataa aatattgtct gaataccctc
     4441 cataatttga tgggcgttca tagtatgcag gggcttttct tcccattgtt taatagcatc
     4501 ctcatatcct tttcgtgccg tttcccagcg tgcaacgctg ttcataagtg tcctacgtaa
     4561 agagcgtggg gaaagggatt tgatagcaat caaaagtggc tttgatttag cagaaagata
     4621 aacatatcca ttaataaccg tatatgcccc gttttttggt aataattttt tcgcactttt
     4681 accaaacata tctatccata aaagctctga tgcacggttt acgatttcaa gaccaagcgt
     4741 ggcaaacaaa ggtgtaacag gatttggcaa gtgttctgcc aaacttccct ttgtgtatac
     4801 aacatcctgt tctggcaata cccattctgg tggcagaaca gtaattggac gagcctgaac
     4861 aatgtacaat ttatcttttt ccagtgccca ctctacatcc ataggcattt gataatactt
     4921 ctcaattttc tttccaagct gtatcagttg cattacctga ttacgagtaa gagcatattt
     4981 ttttctcaac ctttcaggaa ccatggtttc ttctgttcct tctgaagtac gaaccgtcat
     5041 aatctcttta tttgccactt catacgatat aattcgttcg gaatccttat ccactacgat
     5101 tgtatcgggt gtaactaagc tagaaaccac cgcttcacca agcccccatg cagcgttaat
     5161 aatcatttcg ctacgtctac cattgattgg gtttaacgta aacataatac cagatgaatc
     5221 ggaaaatgca agcttttgta ctacaacagc aagtgcgaca atctcgtgct ttatattatt
     5281 cttcacacga taagcaatag cacgagctgt ccataaggaa gcccagcatc tctttacagc
     5341 gtcaataact ttatcttcac cttgtatgtt aagataagtt tcctgctgac ctgcaaaaga
     5401 agcgtcaggt aaatcttcag cagtcgcaga cgaacggaca gccaccgata tgttccctaa
     5461 tccggcataa gccgttttaa ttgcatccga cacttcctgt ggcatttctc cattatggaa
     5521 aagctcccct attttcttag atacatcttc aagttggctg gtattattgg aatcaatacc
     5581 atctagcagt ttattaattc gagactgaat atggttcgtc tcaacaaaaa tctggtatga
     5641 agcagtcgta acatgaaaac cgtctggcac agggatacct gctgtcaata gttttgataa
     5701 agacatccct tttccaccaa caatttcaat ggttgcttgt ttatgttcca gtggcaagac
     5761 ataataaatc ataatcattc acctccatca ttcataattc cgtgcagaaa tatattcatt
     5821 gtttcatcca acattttttc cgaactatcc gatggtcgtg acgtgtagct gattgataac
     5881 atggagttaa ttaacaaacg tgtcacaaga gcggtatccg ttttgcgaaa gatgcctgtg
     5941 gtcacaccat tatcaattac cgattttata atatcttgat atgcataacg agcatcttta
     6001 agtctctttc gatactcttc ttctaaataa tcagattctg tatttaacca catcagtaca
     6061 gttctatact gctctggaaa tctaagatga ttaagcatga tttttctaag gcactgttgt
     6121 ggtgaaggtt caccatcaat aatcctatga acttgttgga tagttttttc tatttctttc
     6181 tcaactgcat atacaacaat ctcgtctttc gttttgaaaa aatcgtatag acttgacttt
     6241 cccatgttgg ctaaaactgc aatttctctc attgatgttt tttggaatcc attttcagcc
     6301 atgagactca aagcaacagc aactattttt tctcggcgtt ctgcttgttg ttcgggtgta
     6361 agcacaattc cttttggcat agggcgatac ctccttttag cgaccactgg tcgtttcttt
     6421 tttatttatc atacagcgac caacggtcac ttgtcaaggt taattttttt cattgtatat
     6481 ggtactcgag ataaaaatgt tcattttaga atttgctcta tttaagtaga aataggcttc
     6541 atcattagaa aacaagacta taaatttgag atatttatca tgttcaaatt tcatcaatat
     6601 caaagtttaa gatattaata aaaaaagaat tactaagaaa taacatataa agattcaaaa
     6661 aaggagttga acttaaaatt taattacaaa aaatcaaatt taagacaact cctttattct
     6721 ttatctctac tattctttat ctctatttat ttattacaac tccctaacat ttaccactac
     6781 tgccttaggt ctagtcatag cctcgattga atacttaaca ccttgagttc ccataccaga
     6841 tgcctttaca cctaaaaatg ggaagtggtc tggacctctt tcagtcttat tatttatttg
     6901 aacagtacca acttcaagtt tatcagctat ataaaatgcc ttatcaatat cacttgtaaa
     6961 tactgatgat tgaagcccat actctgattg attagcaatt tcaattgctt gatttatatc
     7021 tttaactctt ataattggaa gtactggacc aaatggttct tcccaagcaa ttttcatatc
     7081 aacatttaca ttatctaaca atgttggata gaataaatta ttttttctaa cattgcctgt
     7141 tattaacttt gctcctttat gtaatgcatc atcaaccaac ccttgaacaa aatcagttgc
     7201 tttattatct ataagaggag tgataactac ttcatccatt ggatttccaa ttgtcaactt
     7261 ctctaccaat ggctttattt ttccgaccaa tttatccgcc acactctctt gtactaaaat
     7321 tctctttact gccgtacatc tttgtcctga atatgaatac gctccagata ctatattctt
     7381 agctgcaaaa tctaagtctg catcttctaa tactatagcc gcatcttttc caccaagctc
     7441 caataataat ggtaccattc cagatatttt agatatatgc tgaccaactt cagtactacc
     7501 agtaaagtta ataaaattaa ttcctttatg cgttacaaca taatctccta tctcactacc
     7561 cctacctgta atagtattaa gtactccatc tggtatccca gcttttctca taatttctac
     7621 cacatgaagt gcgctaatag ccccttgtgt agcaggtttt aatacaactg catttccacc
     7681 aataagtgct ggagcaatct ttgacattga taaatttaca ggataattaa aaggagatat
     7741 agctaaaaca gtacctaatg gaacccttga aacataagac atcttatttc ttgttccacc
     7801 agggaaatta tctccactaa tggcttcacc ctccatattt tttcccacat cagctgtgta
     7861 tcttaaaaaa tctgctgttc tctcaacttc tgcccttgca gattttatgt ctttggctat
     7921 ttcaagtacc agtacattag ctatctcatc tatattttct aacaataaat cagcagcctt
     7981 atgaaatata ttggctctct tgtatacagg catttcagcc catactttta tactctcttt
     8041 tgtgtttttt ataacctcat ctacctcatg ttttgtcata gattgtactt tcccaacaag
     8101 agaattatct attggtgagt aaatttctat tggctttctc gaattagatt ctacccattt
     8161 tccatttatt aaatttttat atacattttc ttttgtttta agttcattaa acatattttt
     8221 attcctctct ctgatataac tttgtgtatt taaattatag ccatttattc gttatgtaaa
     8281 catttctttt tttcataaac gtttacctat aaaaaaaatt ttaagttaac gtttttctac
     8341 attcttctat tttaataaca tactcgctcc aaatctatat aggtcacact ttaatatcaa
     8401 tatactaata taccaatata ccaatatacc aatataccaa tataccaata taaatattat
     8461 aaacataaat cacttgacaa atttataagt agacaatatt atatatctat gactcaaaat
     8521 atttttaaag tcatatatat catatataga tagaaaggat tgataaacat ggctaaaagt
     8581 tttacagaaa tagaaaaaga caatataaga aaaagactaa tttcagaatg tgaactcaac
     8641 tggtctaaat atggatacaa aaaaactaat attgatgaac tttgttcaaa atcaggaatt
     8701 gcaaagggtt ctttctatac attttttgat tcaaaagaaa agttattttt tgaagtatta
     8761 aatggaatcc aaaacagact tatatcatca gtagatgaaa ttttaagtaa catgcctcca
     8821 aaagaaggct ttgcaaaatc cttaaaaatg ttatatcgat tatatgataa aaatccattt
     8881 ttatattcac caaataatcc tgatttcatc agcctaataa ataaactacc tcaagatatg
     8941 tttttacaac ttgagtccaa taacatacaa agtttttacg acttaattga gagacacaat
     9001 ctcaagttga agatagaaaa agaaaaagtt tttggtgttt gtaatgctct actatcaagt
     9061 ctattggtaa aagaaaatat tgaatataac tatattgaag tgtttgactt tatggtggat
     9121 aatcttgtag aacacatact tgaataacaa tttaaaataa tttttctaag tattttttta
     9181 tactaaatag gattaatatg attgaattaa tacaaaaaat aaacaatata atttataaaa
     9241 taaatgataa actaaatatc acacaaaact tatagaccct agagcaaacc cattccactc
     9301 tactctaagc catctataat agtttgtata tttctaataa tattagatat taaagtaaga
     9361 aaaaaattcc ttataataat tgctattata tcaattatta taaatatttt aataatctta
     9421 gataggtagg tacatatatg gtaaaatcct cgaacacttt taataaaaac ttcaacttga
     9481 tgatattagg tcaaataatc tcattgtttg gtgcatcaat acttaaattt gctttatctt
     9541 tatacatact tgatataact ggtaaagcag aaatatttgc tactatacta gcagtatctt
     9601 caatcccaat tatagtattc tcccctattg gtggagctat tgcggatata ttcaacagaa
     9661 gaaacttaat ggttattttt gatttttcaa gtagtcttac agtactaatc ttagcagtat
     9721 tcttattcaa caataatggt tcaatattac ttgtaggaat tattatgacc atattatcag
     9781 tcataagcac aatgtatcaa ccaactgttc agtcaagtac acccctttta gttgataatg
     9841 agcatttaat gaatgcaaat ggtattgtag ctggagttgc atctcttaca aatattgcag
     9901 gacctgtatt aggaggtgtc ttgtatggtg tgattggaat taatgcaatt atagttatca
     9961 gttgtgtaag tttctttcta tctgcaatta tggagatatt tatacagatt ccttttatca
    10021 aacaagagca aaacagcaac attataaaaa ctatatttac tgatataaag gatggtattg
    10081 ttcatatatg taaagaaaat agatttatac taaaaatact ttttttagct atagcaataa
    10141 acttattttt aagctctatg ttaatagttg gtatccccta tatagtaaaa atcactatgg
    10201 gagctagtaa cttcttatat ggtctagcag aaggagcaat ttcttttagt tcactggtag
    10261 ctgctgttag tattggtatt ttctcaaaac atctaaaaat cactaatttg catatttcct
    10321 ttattatatg tgcagttatg ttcataccaa tggcggtttc agtatatcca tttatattaa
    10381 acacaggatt tccagttcca tttttaatct ttatagtatc atctatgcta atatttttta
    10441 caacgactct tatctcaata tatgttataa cagtcacaca attaaaaact ccaaatgaac
    10501 tcttaggaaa agtaatgtca attctttttg caggaacagc aattgcaatg ccccttggtc
    10561 aggttatgta tggtaaactt tttgatttat tatcagatag agtgtacatc attatactag
    10621 tagttggatt tattacatta cttatagcat ttgtatcaaa gataacattg aggaacgaaa
    10681 atctttagat acaaagaatt tagatataaa gatttaattt tcactaattt ctgaatttaa
    10741 atgcaaaatt gtgtatcagt atgttgacgt tttagaaatt gattgatata atcaatggaa
    10801 aataaacttt ataaaaattc aaaatattca gctagaggag tgataaaaat gagttacatg
    10861 ccaactttag aacaagcatg ggaaatatta agaaaataca ataaggaaga atttcatata
    10921 agacatgctc aaattgtatc tggagttatg agatactatg caaaggagta cgaccctgaa
    10981 agagtagaat tttgggaaat agttggactt ttacatgatt tagattttga aatgtatcct
    11041 gatgaacatt gcgttaaaca aagagaatta atgacagagc ttgatttaga taaatcaata
    11101 atcgattcta caataagtca tggatatgga ttaactggtt cagatgttaa accagagcaa
    11161 tttatggaga aagtattatt tgctgtggat gaacttactg gtttaattgg tgctgctgca
    11221 ataatgcgtc cttcaaagag cgtttctgat ttagaattaa aatctgttaa gaagaaattt
    11281 aaagataaat catttgctgc tggctgttct cgagacgtta taagaagtgg tgcagaaatg
    11341 cttggatggg aacttgataa gcttatccaa acaactatag aagctatgag aagcttgatt
    11401 ccagagatgg caatatagct cctccataca tataccatag aagttacatc tttaaagagc
    11461 atttctcttt ttgatgcaac ttctttttat attttgtaga ataaaaagtt taatatttta
    11521 aactcactat ataataaata atataatgta taatagtcat aaactttcta accttaaaag
    11581 tttctaataa tcaataaaca attctaat
//
LOCUS       DAEQCW010000111        11578 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.112, whole genome shotgun sequence.
ACCESSION   DAEQCW010000111 DAEQCW010000000
VERSION     DAEQCW010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11578)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11578)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11578
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.112"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            73..1455
                     /locus_tag="KRO40_002983"
     CDS             73..1455
                     /locus_tag="KRO40_002983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011967718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBH2093792.1"
                     /translation="MLSKNIASKVLEKCLITGGDFAEIFEEDTINNSISLIDNKVENA
                     IGGRNYGIGIRIFKGLKSIYAYTSDNSLNSLLDVAYKAAVALGKLEDGKSVILNDSIK
                     INNIHNIKIYPNSIGNKDKVSVMKVAYKSAKEFSNDISQVSVSYLDKDQKILIANTEG
                     IYVEDRRIRTRLGISSIASKGNENQTGFEGPGGCKGFEIFEEIDPEYYAKESARVAHT
                     MLHAKNCPAGNMMVAIDNGFGGVIFHEACGHSLEATSVAKGNSVFADKLGQQIASTKI
                     TAIDDGTIPNYWGSMNIDDEGNPTQKNILIENGILKSYMIDKLNGRRMGMNPTGSSRR
                     QNYKFAPTSRMTNTYIAAGEDKPEDIIKSIPDGLYAKKMGGGSVNPVTGEFNFAVSEG
                     YLIKNGEIQEPVRGASLIGKGSDILMNIDMIGNNVKQAQGMCGSSSGSIPTNVGQPMI
                     RVKEITVGGR"
     gene            1467..2816
                     /locus_tag="KRO40_002984"
     CDS             1467..2816
                     /locus_tag="KRO40_002984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBH2093793.1"
                     /translation="MELKNFKDILFKKALSEGFEECEIYYYTGENLSINIYEGEVEKY
                     NLDKSFGLSFRGKVNGKIGYSYTEILDDKAVDMLIKNVKDGVNTIENEDVQFIYEGDK
                     HYNDVKTYSKELENLEADKLIDLALEMERETKAYSDKVVNLSKCTISYSVSSNGISNT
                     KGLNLSNKTNMLIGFVVPIIEDNGQKYDGIGYNIANSIEEIKPCEIAKLGVDNALSKV
                     GGKSIPSGKYKTILLNEAMVSLLSTFSGIFNADSAQKGLSLLKNREGDMIASPIVTIV
                     DDPLLENGMASTPFDDEGVATFKKEVVLNGKLITLLHNLKTANKAGVKTTGNGIKSSY
                     SSPISIYPTNFYIEKGDKSLDEIIKDIDEGLMVTSFAGLHSGANSVTGDFSLAAKGFY
                     IKEGKKVFPVEQITVAGNYFDLLKDIEAIGEDLEFPMSSIGSPSVVIKELSVAGKDE"
     gene            2966..3499
                     /locus_tag="KRO40_002985"
     CDS             2966..3499
                     /locus_tag="KRO40_002985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH2093794.1"
                     /translation="MSDAHYDMHKRNGYSSDEPYPEIKVLGPNKYYAELLMDDYAGVS
                     SEFTSVNQYLYHNFDLDETHRELSEMWINISITEMLHMEILAKTIRLLGGNPVYRGST
                     SSCGAYWNGGFVCYGNSICNRLKLDLHLEHVAINNYYKDISLIEDPYIKAILNRIILD
                     EKLHVSLFEKAIEKYCK"
     gene            3583..4392
                     /locus_tag="KRO40_002986"
     CDS             3583..4392
                     /locus_tag="KRO40_002986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2093795.1"
                     /translation="MYYVYVNDINIAVYDLNPSAKKTVLFIHGWPLGHKIFEYQTNIL
                     PKLGYRTVSIDLRGFGKSDATSGGYTYSQLADDIYKVVHAIGLKDFTLVGFSMGGAIV
                     LRYMSLFNGYGVSKLVLAAAAAPSFVQRPPEFPYGMTREDVNKLIAQACTDRPEMVTD
                     FGEKVFASNPPESFRRWFNDIGFSASGIGTIGTAVSLRDEELFNDLKCVRVPTGIFHG
                     KLDEICPYEFAVFMNEKIEDSILYTFEYSGHAIFYDELKLFNQEFLQFLEE"
     gene            4803..6848
                     /locus_tag="KRO40_002987"
     CDS             4803..6848
                     /locus_tag="KRO40_002987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093796.1"
                     /translation="MKKHNILFVSTDDKINIDISKQLENIFGEFCNIDNLVYVNRINI
                     ELSSYELVVCSDNDIKEYIHNNIDKNIPIVIVHRTINIENINQIISIENDSDVMVIDA
                     YKESADETAKIIRKLGLIHINLIPYYPGCDKSKCEIGIITGSRNSIPQNIKQIIDIGD
                     KVIDINTVIEIFTKLNISIDKLHIIKEKYNEDTVSGYRYYTTMNKTMKSFLEIIDEGI
                     ASVDKLGKFIYCNKVFSNLVGIDQNEIISNNFMDLFSDKVVKKIFFQEDEVNDEVVNL
                     NNKKLIINKVNVYENNERIKSIISIKNISAIQVLEDKIQNKLQSKGFVSKYTFESVVG
                     ESKIIKEKINIARKIATTDFSVLILGENGTGKEIFAQAIHNESLRKNKPFVAVNLSSL
                     SDTLIESELFGYDEGSFTGAIKGGKMGIFERAHTGTIFLDEIGDISLDVQQRLLRVLQ
                     EKEVMRMGGSKIIPIDVRIIAATNKDLKKKIKEGSFREDLYYRINVLHIEIPRLRERK
                     EDIPLISKYFLDEINSNKCFTEESMQALTLYEWPGNVRELKNLIYYIDTIVEEDRVDY
                     EHLPEQFRFEKNNTLVNENFDSIILDFKQSNFFEESICILTSIETWNNKNILLGRNKL
                     QEILKEKDIVLSVDQIRKRIDKLKSHGLLLSGVKKQGSFITDEGKNFISYVKIKGVI"
     gene            7109..8308
                     /locus_tag="KRO40_002988"
     CDS             7109..8308
                     /locus_tag="KRO40_002988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane dipeptidase"
                     /protein_id="HBH2093797.1"
                     /translation="MKSAYKGYEAYSYLEKGKDISSIEMCKGDKRVKEYLIELDDIQE
                     AKVKSIVDEKIFISLHEHPVLFPEHLERDIFEYNREGKQRCAYEALSRGYYDAIFDNL
                     MDGVCTITSNSGWKWDDILIDLGMRLCDLAHQDFVIKCEKVEDIYRAKSEGKVALIPT
                     LEGAAPIENELDRIDILYGFGIRLMGITYSESNALGSGLKEEKDGGLTNFGKKAVERM
                     NKIGMAIDCSHVGVQTTLDVIEYSKDPIILSHVGARNLWNTKRLTPDEVLIACAKKGG
                     VIGVEAAPHTTITEKNKEHSIESFMEHFEYIKNLVGIDHVAFGPDTVYGDHVKLHSVL
                     AAKFDIKKITGTKEHPKVEYVKGLENPTETSKNIVRYLVKHGYSDEEIEKVLGGNILR
                     VLKQVWK"
     gene            8360..9055
                     /locus_tag="KRO40_002989"
     CDS             8360..9055
                     /locus_tag="KRO40_002989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5058 family protein"
                     /protein_id="HBH2093798.1"
                     /translation="MDYLKLANHPLLWIASTVAVSIVVVQSLIFAIKSCKVGKTMGIT
                     DKQIKSAVKSSAISAIGPSMTIFAGMVSLIVTMGGPIAWMRLSFIGSVIFESMSAGFG
                     TDALGITLGSPEMTKLAFTNAVWTMILGSLGWIIFTLLFGHKLDKITNVISSGKKSFI
                     PIISLGAMLGSFAYLNADRVLRFDNGTIACISGMAIMVILCMLEKKKNIKWLREWGLT
                     ISMFSGMIIASVI"
     gene            9072..9749
                     /locus_tag="KRO40_002990"
     CDS             9072..9749
                     /locus_tag="KRO40_002990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093799.1"
                     /translation="MSKVKSIYNEEYLPFMIRYGRLTLSLGIIAALVPGIILSFGFGI
                     MPPISALLASTMAIVSMSAPNYIIEPVSYSPILGIPGTYMSFLSGNISNMRLPCSIAA
                     QKAAEVESGTEEGSIISTIGIAVSILVNISILTIGVILGGSVLSKIPAEVVEKLNLIL
                     PALFGSVFGQVFLQDKKLGLVAIVISVLTIILSKQGIIPQSLVVLICVFGTILIARAM
                     YKDKLSD"
     gene            9860..11461
                     /locus_tag="KRO40_002991"
     CDS             9860..11461
                     /locus_tag="KRO40_002991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH2093800.1"
                     /translation="MIYDLILKNGFIIDGTGNPGFYGDIAIKDNLIAKIDSKINSNTN
                     KEIDCCGKVITPGFIDPHVHEEIVAILDGKFEKFLKQGVTTTINGNCGHSITPYSSEN
                     VYEYMYKNGLLLEEEKKYLIDKNKCWNNFTEYCDLISKSGISVNMGFLLGHGTIRWSV
                     MGGSKDRPPTEKEKNEITDIINDGMKSGAFGISTGLAYIPSKYADIDELVDIARQIKE
                     YDGIYTSHIRDYIGRYNAVKEAIEVGQKSGARVQVSHLSPVEIEAFDEILKARYNGVE
                     IMVDTVPRSSGHCMKKKRVIQFIMAISSSLFELGIDGVMDALRNEEGRTLILKEAFIL
                     GDRGSIILLNTKDINMEKKSIREIATQKGIDEDKLLLDLLLDGDEELIFCLGGMYRAD
                     FPDKLHDDKIIDNPFVMVGSDCLFSVGGDMSWFELQRRGAFPIFFNMYRKSGVRLEEI
                     VRRVTSLPARQFKIKNRGILKEGLIADIAVIDMDNYSYPRSEDIDFSKPQLLANGVEY
                     VIVNGKIALENGEITENKCGEVLKR"
BASE COUNT         4548 a         1158 c         2201 g         3671 t
ORIGIN      
        1 tatataatgt ttgttaacaa gtaaaaagat tgaataaaag ttaattaaaa atttaaagta
       61 ggaggtaaat ttatgctttc aaaaaatata gcttctaagg tattagaaaa gtgtctaatt
      121 actggaggag attttgctga gatttttgaa gaagacacta taaataattc tattagttta
      181 atagataata aagtagaaaa tgcaataggt ggaagaaatt atggtatagg aataagaata
      241 tttaaaggat tgaaaagtat atatgcttat acaagtgaca attcattaaa tagtctgttg
      301 gatgtagcat acaaagctgc tgttgcttta ggtaaattgg aagatggaaa aagtgtaata
      361 ttaaatgaca gtattaaaat aaataacata cataatataa aaatttatcc aaattcaata
      421 ggaaataaag ataaagtaag tgttatgaag gttgcatata agagtgcaaa agaatttagt
      481 aatgatatat ctcaagtaag tgttagttat ttggataaag accaaaaaat attaattgca
      541 aacactgaag gtatatatgt tgaggataga agaataagaa ctagactagg gataagttca
      601 attgcatcta agggtaatga aaatcaaact ggatttgaag gtcctggagg ttgtaaaggg
      661 tttgaaatat ttgaagaaat agacccagaa tattatgcaa aagaatcagc tagagtagca
      721 catactatgt tgcatgctaa aaattgtcct gcaggtaata tgatggtagc aatagataat
      781 ggatttggtg gagtaatatt tcatgaagct tgtggacatt ctttggaagc tacatcagtt
      841 gcaaagggga actctgtatt tgcagataaa ttaggtcaac agattgcttc cacaaagatt
      901 acagctatag atgatggtac aataccaaac tactggggtt ctatgaatat agatgatgaa
      961 ggaaatccaa ctcaaaagaa tatactgatt gaaaatggaa ttttgaagtc ttatatgata
     1021 gataaactta atggtagacg aatgggaatg aatcctacag gaagttctcg tagacagaac
     1081 tacaaatttg caccaacttc aaggatgact aacacttata ttgctgctgg agaggataaa
     1141 ccagaagata ttataaagtc aataccagat ggactttatg ctaaaaaaat gggtggtggt
     1201 tctgtaaatc ctgtaacagg agagtttaat tttgcagttt cagaaggtta cttaataaaa
     1261 aatggagaaa tacaagagcc agttagaggt gctagtttaa ttggaaaagg tagcgatata
     1321 cttatgaata tagatatgat tgggaataac gtaaaacaag ctcaggggat gtgtggctca
     1381 tcatcaggaa gtataccaac taatgtaggc caacctatga taagggtaaa agaaattact
     1441 gtaggtggaa gataggaggg ataattgtgg aacttaaaaa ttttaaagat atattattta
     1501 aaaaggctct aagtgaaggt tttgaagagt gtgaaatata ttattataca ggagaaaatt
     1561 taagtataaa tatatatgaa ggagaagttg agaaatacaa tcttgataaa tcttttggtt
     1621 tatcttttag aggtaaggta aatggaaaga taggttattc ttatacagaa attttagatg
     1681 ataaagctgt tgatatgttg ataaaaaatg taaaagatgg agtaaacact attgaaaatg
     1741 aagatgtaca atttatatat gaaggagata agcactataa tgatgtaaag acttattcta
     1801 aagagctaga aaatttagag gcagataagt tgattgattt agctttagaa atggaaagag
     1861 agactaaagc ttattcagat aaggtggtaa atttatctaa atgtactata tcttattctg
     1921 tatcaagtaa tggtatatct aatactaaag gtcttaattt aagcaataaa actaatatgc
     1981 ttatagggtt tgtagttcct atcatagaag acaatggaca aaaatatgat ggaataggat
     2041 ataatatagc aaattctatt gaagaaataa aaccttgtga gatagcaaaa cttggtgttg
     2101 ataatgcttt atctaaagta ggtggtaaga gtattccatc aggtaaatat aaaactatat
     2161 tgcttaatga agctatggta tctttgctta gcacattttc tgggatattt aatgcagatt
     2221 cagctcaaaa aggattatct ttattgaaaa atagagaagg agacatgata gcatctccta
     2281 tagttacaat agttgatgac ccacttttag aaaatggtat ggcatctact ccttttgatg
     2341 atgaaggagt agctacattt aaaaaagaag ttgttttaaa tggaaagctt ataactttac
     2401 ttcataactt aaaaacggct aataaggcag gtgtaaagac tacaggaaat ggaataaaat
     2461 cttcatattc atcacctata agcatatatc caactaattt ttatatagag aaaggagata
     2521 aatctttaga tgaaattata aaggatatag atgaaggatt gatggttact agctttgcag
     2581 gacttcattc aggtgcaaat tcagtaacag gagacttttc tttagctgcc aaaggctttt
     2641 atatcaaaga aggaaaaaaa gtatttccag tggagcaaat tacagtagca ggaaactatt
     2701 ttgacctgtt gaaagatatt gaagctatag gagaagattt agaatttcca atgagtagta
     2761 taggttcacc ttcagttgtt attaaagagc tatcagtagc tggaaaagat gaataattaa
     2821 aaagtaattt tgtggataaa aggtcatgtt aattttaatt aatatggctt tttattattt
     2881 aagtagattt tattatctaa gttatatgaa aaagttgtga tgcatacaat taatatcata
     2941 cattaaattt aaaggaggag atattatgag tgatgcacat tatgacatgc acaagcgaaa
     3001 tggatattca agtgatgagc catatccaga gataaaagtt ttaggtccaa ataagtacta
     3061 tgcagaatta ttgatggatg actatgccgg agtatcaagt gaatttacga gtgtaaatca
     3121 atatctatac cataattttg atttagatga aacgcataga gagttaagtg aaatgtggat
     3181 aaatatatct ataacagaaa tgttacatat ggagatatta gcaaagacta taagattatt
     3241 gggtggaaat cctgtatata gaggttctac aagttcttgt ggtgcatatt ggaatggtgg
     3301 ttttgtatgt tatggaaatt ctatttgtaa cagattaaaa ctagatttgc atttggagca
     3361 tgtggctatt aataattatt ataaagacat aagtcttatt gaagaccctt atataaaagc
     3421 tatattaaat agaataatcc tagatgaaaa acttcatgta agtttatttg aaaaggcaat
     3481 agagaagtat tgtaaataaa tttgaaaatt tagttattca tcattttatt catatatata
     3541 aaataaccat catacatttt cttgaaggga gttgctgttg atatgtatta tgtatatgtg
     3601 aatgatataa acatagcagt atatgatttg aatccgagtg ctaaaaaaac tgtacttttt
     3661 atacatggtt ggcccttagg acataagata tttgaatatc aaacaaatat attgccaaaa
     3721 ctcggatata gaacagtttc aattgattta agaggttttg gtaaatctga tgcaacatca
     3781 ggaggatata cttatagcca attagcagac gatatttata aggtggtaca tgctattgga
     3841 ttaaaagact ttacccttgt tggtttttca atgggaggag caatcgtact taggtatatg
     3901 agtttattta atggatatgg agtgtcaaaa ttggtattag ctgcagctgc tgcaccatca
     3961 tttgtacaaa gacctccaga atttccatat ggtatgacac gtgaagatgt aaataaattg
     4021 atagcacaag catgtactga tagaccagaa atggtaaccg attttggcga aaaagtattt
     4081 gcatcaaatc caccagaaag ctttagaaga tggtttaatg atattggttt tagtgcatca
     4141 ggtattggca ctattggaac tgctgtatct ttaagagatg aagaattatt taatgattta
     4201 aaatgtgtaa gagtgcctac tggtatattt catgggaaat tagatgaaat atgtccgtat
     4261 gaatttgcag tttttatgaa tgaaaaaata gaagattcaa ttttatatac ttttgagtat
     4321 agtggtcatg ctatattcta tgatgagctt aaactattta atcaggaatt tttacagttt
     4381 ttagaggaat agatatattt tattatcact tagaaaaaga gtaatattat gtgaaaagat
     4441 ttaagctaaa ttttatgatg ttttttacac taaacaaata gggttttaga acttgtaact
     4501 aagttctgag accctattat tatatattcc taaaatttgt tataatttat tccttgtcat
     4561 tcttaaaaat gtattaatat attaacgaat ttatattaaa tttttgttta tattccaata
     4621 atgtcaaact aaccgtttta gaaattaaat tatatgtgaa aaaagatagc ttacattatt
     4681 ttattatgga aaataatagt aaatggtaca aaatttgatt tttaagattt aaaacttttt
     4741 taaaaagtgc tacaatagac caaattatta ctttctatac tcgttaaaca ggaggtggga
     4801 ctatgaaaaa acataatatt ttatttgtat caactgatga caaaataaat atagatatat
     4861 caaaacaatt ggaaaatata tttggagaat tttgtaatat agataacttg gtatatgtaa
     4921 ataggataaa tattgaactg tcaagctatg agcttgtagt atgttcagac aatgatataa
     4981 aggaatatat acataataat attgataaaa atatacctat tgtaatagta catcgtacta
     5041 taaatattga aaatataaat cagataataa gtatagaaaa tgattctgat gttatggtta
     5101 tagatgctta taaagagtca gcagatgaaa ctgccaagat aattagaaaa ctaggattaa
     5161 ttcatattaa tctaatacca tattatccag gttgtgataa gtctaaatgt gagattggaa
     5221 ttattacagg aagcagaaac agcataccac aaaacataaa gcaaataatt gacataggtg
     5281 ataaggtaat tgatataaat acagttatag aaatctttac aaaactaaat atatctatag
     5341 ataaattaca tattattaag gaaaaataca atgaagatac agtaagtgga tataggtatt
     5401 atacaactat gaataaaacc atgaagagtt ttttggagat tatagatgaa ggtattgctt
     5461 ctgttgataa attaggaaaa tttatatatt gcaacaaagt attttctaat ctagttggaa
     5521 tagaccaaaa tgaaattata tctaataact ttatggactt atttagtgat aaggttgtca
     5581 aaaaaatatt ttttcaagaa gatgaagtta atgatgaagt agtaaattta aataacaaaa
     5641 aactgataat taataaagta aatgtttatg aaaataatga acgaataaag agtattataa
     5701 gcattaaaaa tataagtgca attcaagtgc ttgaggacaa gattcaaaat aaacttcagt
     5761 caaaaggttt tgtatcaaag tatacatttg agagtgttgt aggtgagagt aaaataataa
     5821 aagaaaaaat taatattgca agaaaaatag caactacaga cttttctgtg ttgatacttg
     5881 gagaaaatgg aacaggaaaa gaaatatttg cccaggcaat acataatgaa tctctaagaa
     5941 aaaacaagcc atttgttgca gttaatctat cttctttgtc agatacactt attgaaagtg
     6001 aactttttgg ctatgatgaa ggaagtttta caggagcaat aaaaggtggg aaaatgggta
     6061 tatttgaaag agcacacaca ggaacaattt ttttagatga gataggtgat atatctttag
     6121 atgtacagca gagattgcta agagtattac aggaaaaaga agttatgaga atgggcggaa
     6181 gtaaaattat accaatagat gttagaatta tagctgcaac aaataaagat ttaaagaaaa
     6241 aaattaaaga aggttccttt agagaagatt tgtattatag gattaatgta ttacatatag
     6301 agatacctag acttagagaa cgtaaggaag atatacctct tataagtaag tattttttag
     6361 atgaaataaa tagcaacaaa tgttttacag aggaatcaat gcaagcttta acattgtatg
     6421 aatggccagg aaatgtaaga gagcttaaaa atttaattta ttatattgat actatagttg
     6481 aggaagatag agtagattac gagcatttgc cagaacaatt tagatttgaa aaaaacaata
     6541 ctttagttaa tgaaaatttc gattcaatta tcttagattt caaacaatct aatttctttg
     6601 aggaaagtat atgtatattg accagtatag aaacttggaa taataaaaat atattattag
     6661 gaagaaataa actgcaagag attttaaaag aaaaagatat agttttaagt gtagaccaaa
     6721 ttagaaaaag aatagataag ttaaagagcc atggtttact tttatctgga gtaaaaaaac
     6781 aaggtagttt tataactgat gaaggaaaga actttatatc atatgtaaaa attaagggag
     6841 tgatataggg gactaaaaag gcaaaacacc ctaaaaaaat ccctataatg gatagaaata
     6901 aataaaatta tctttaagat taagataatt caaaaatatt gaataaataa tctaagaaga
     6961 ttatttttaa taaaacagta gtaaatatca accttactac tgtttttatt ttttgcaaga
     7021 tttattatac aattaaaatt tatattttgg cacatcaatt gctacatagg aaaaatataa
     7081 aaaattgtaa aacttggagg atgttgttat gaagtcagct tacaaaggat atgaagccta
     7141 tagttattta gaaaaaggaa aagatatttc atctattgag atgtgtaaag gagataaaag
     7201 agttaaagaa taccttattg aattagatga tattcaagaa gctaaggtta aaagtatagt
     7261 ggatgaaaaa atatttatat cattacatga acatccagta ttatttccag aacacctaga
     7321 aagagatata tttgaatata atagggaagg taaacaaaga tgtgcttatg aagcattatc
     7381 aagaggatat tatgatgcta tatttgataa tttaatggat ggtgtatgta cgataacatc
     7441 aaattcaggg tggaaatggg atgatatatt aatagattta ggcatgagat tatgtgattt
     7501 agctcatcaa gattttgtca taaagtgtga aaaagtagaa gatatataca gagctaaaag
     7561 tgaaggtaaa gtagcattga taccaacatt agaaggtgca gcaccaatag aaaatgaact
     7621 tgatagaata gatatactgt atggatttgg tataaggtta atgggtataa catacagcga
     7681 atccaatgca ttaggttcag gactaaaaga agagaaagat ggaggtctta caaattttgg
     7741 gaaaaaagct gttgaaagaa tgaataaaat tggaatggca atagattgct ctcacgttgg
     7801 agttcaaact acacttgatg taatagaata tagcaaggac ccaataatat taagccatgt
     7861 tggggcaaga aatttatgga acacaaagag actaactcca gatgaagtat taatagcatg
     7921 tgctaaaaaa ggaggggtta taggtgtaga agcagcacct catactacaa taacagagaa
     7981 gaataaagaa cattcaatag agtcatttat ggaacatttt gagtatatta aaaatttagt
     8041 aggaatagac catgtagctt ttggaccaga tacagtatat ggcgaccatg taaaattaca
     8101 ctcagtacta gctgctaaat ttgatataaa aaaaataaca ggaacaaaag aacatcccaa
     8161 agtagaatat gtaaaaggtc ttgagaaccc aacagaaact tcaaaaaaca ttgttagata
     8221 tttagtaaag catggatata gtgatgagga aatagagaag gtactaggtg gaaatatact
     8281 tagagtacta aaacaggttt ggaaatagat atattagaaa tattaataaa atttgaggat
     8341 ttatagggag gttttataaa tggattattt aaaattagct aatcatccac ttttgtggat
     8401 agcgagtaca gtagcagtat caatagtagt ggtacaatcc cttatatttg ctataaaatc
     8461 ttgcaaagtt ggtaaaacaa tgggaataac agataaacaa ataaagtcag ctgttaagag
     8521 tagtgctatt tcagctattg ggccttcaat gactatattt gctggaatgg tatcgcttat
     8581 agtaactatg ggtgggccta tagcatggat gagattatca tttataggtt ctgtaatttt
     8641 tgaatcaatg tcagccggat ttggaacaga tgcattaggt ataactttag gttctcctga
     8701 aatgacaaaa cttgcattta caaatgcagt ttggactatg atattaggtt ctttaggatg
     8761 gataatattc acattactat ttggacataa actagataag ataaccaatg ttatatctag
     8821 tggcaagaaa tcatttatac caataatatc tctaggagca atgttgggtt catttgcata
     8881 tctaaatgct gatagggtgt tgcgttttga taatggaaca attgcatgta taagtggaat
     8941 ggctataatg gtaatattgt gtatgcttga aaagaagaaa aatataaaat ggttaagaga
     9001 gtgggggctt acaatatcaa tgtttagcgg aatgataata gcttcagtaa tataaggggg
     9061 gagttagttt tatgagtaaa gtaaaatcta tatacaatga agaatattta ccttttatga
     9121 taaggtatgg aagattaaca ctatctttgg gtattatagc agcattagtt cctggaataa
     9181 ttttgagctt tggatttggt attatgcctc caatatcagc attattagca agtacaatgg
     9241 caattgtcag tatgagtgct ccaaattaca taatagaacc agtttcttat tcaccaatct
     9301 taggtatacc aggaacttat atgagttttc tttctggtaa tatatctaat atgaggctac
     9361 catgttcaat agcagctcaa aaggcagcag aagttgaatc aggtacagaa gaaggctcga
     9421 taatatctac aataggaata gctgtatcta ttttagtgaa tataagtata ctaactatag
     9481 gggtaatttt aggaggaagc gtactatcta aaattccagc tgaagtagta gaaaaattaa
     9541 acttaatttt accagctcta tttgggtcag tttttggaca agtattttta caagataaaa
     9601 aattaggtct agtagcaatt gtaatatctg tattgactat tatattatca aagcaaggta
     9661 taataccaca gtctctagta gttcttatat gtgtatttgg tactatatta attgcaagag
     9721 ctatgtataa agataagctt agtgactaat tacaatgaaa taatagtgaa ttttcaaata
     9781 tgaaatttaa taatttgatt ttcaaatata aaaattacat taagattatt taaaaattgg
     9841 tttttaagga gggaatattt tgatatatga tttaatctta aaaaatggat ttataataga
     9901 tggtacaggt aatcctggtt tttatggaga tatagcaatt aaagacaact taatagcaaa
     9961 aatagattct aagataaata gcaatacaaa taaagagatt gattgttgtg gaaaagttat
    10021 aacacctgga tttattgacc ctcatgttca tgaagaaata gtagcaatac tagatggtaa
    10081 atttgaaaag tttctaaaac aaggagttac aacaactata aatggtaatt gtggacattc
    10141 tataacacca tattcttctg aaaatgtgta tgaatatatg tataaaaatg gtctattact
    10201 tgaagaagaa aaaaagtatc ttatagataa aaataaatgt tggaataatt ttacagaata
    10261 ttgtgacctt atatctaaaa gtggtatttc tgtcaatatg ggattcttgt tggggcatgg
    10321 gactataaga tggagtgtta tgggaggttc taaggataga cctcctacag aaaaggaaaa
    10381 aaatgaaatt acagatataa taaatgatgg aatgaaaagt ggtgcttttg gaatatctac
    10441 tggattggca tatataccaa gtaagtatgc tgatattgat gaacttgttg atattgcaag
    10501 gcagattaaa gagtatgatg gtatatatac atctcatatt agagattaca taggaagata
    10561 taatgcagta aaagaagcca tagaggttgg gcaaaaaagt ggtgctaggg ttcaagtatc
    10621 tcacttaagt ccagttgaaa tagaagcatt tgatgagata ttaaaggcta ggtataatgg
    10681 tgttgaaata atggttgaca cagtaccaag aagttctggg cattgtatga agaaaaaaag
    10741 agtaattcaa tttattatgg caatatcatc tagtctattt gaattaggta tagatggggt
    10801 aatggatgct cttagaaatg aagagggaag aacacttata ttaaaagaag catttatact
    10861 tggagatagg gggagtataa tacttctaaa cactaaagat attaatatgg aaaagaaatc
    10921 aatacgtgaa atagctacac aaaaaggaat agatgaagac aagttattac tcgatttact
    10981 tttagatgga gacgaagaac ttatcttttg tttaggagga atgtatagag ctgatttccc
    11041 agataaacta catgatgata aaataattga taatccattt gttatggttg gttcagattg
    11101 tttgtttagt gtgggtgggg atatgtcatg gtttgaacta caaagaagag gagcttttcc
    11161 aattttcttc aatatgtaca gaaagtctgg tgttagattg gaagagattg taagaagagt
    11221 tacttcatta ccagctaggc aatttaaaat aaaaaataga ggtattctta aagaagggtt
    11281 gatagctgat atagcagtta ttgacatgga taactatagt tatcctaggt cagaagatat
    11341 tgatttttca aagccacaat tactagccaa tggtgttgaa tatgtaattg taaatggaaa
    11401 aattgcatta gaaaatggag agattactga gaataaatgt ggtgaagtat tgaaaagata
    11461 aggttctaaa aataatagga tttagaaagt aaataaatat ctaagtaagt aaagacgaag
    11521 tttgagattt atttaaataa aaattatgct tcgtttttat ttatagtatt aatattta
//
LOCUS       DAEQCW010000112        11574 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.113, whole genome shotgun sequence.
ACCESSION   DAEQCW010000112 DAEQCW010000000
VERSION     DAEQCW010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11574)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11574)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11574
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.113"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(123..1946)
                     /locus_tag="KRO40_002992"
     CDS             complement(123..1946)
                     /locus_tag="KRO40_002992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093801.1"
                     /translation="MNLSTGNQKVSRLKKKEKPKDFKKTFKRIFMYFKKDKKITRFIF
                     LLLIIDSIISTVIPYTIGKVVDIIDIDTYSKSIFLKGIIILLSFYIIEFSVKLSKGIC
                     TARLSQSIVKEMRSNLFLKFKNLPITFFDKSSTGDIMSRVTNDVDNISTGISNSLVQL
                     ITGILNILMTFIMMFVLSPILTFCSVILIPIVMFVSNFIAKRTRVFFKQQQVELGKLN
                     AHIEEMISNINVVKSFNYERKSVNDFKEVNDRLLNISLKSQIYTSLLMPIMNVISNIG
                     FATICIIGGILASKDIITIGVIASFLSYVRQFTRPLNELANLFNTLLSAIAGCERVFE
                     IIDEQEEQEVHNMFKSEINDNKDGNLNSHFVKGEIELKDVSFSYDSKKKILDNINLKI
                     KSGTSNAIIGETGSGKTTIINLITNFYHIDEGSIFLDGKDIYSINRNYLRTCFGVVPQ
                     EGYIFNDTVMENIRYGNLEATDEEVIYASKIANAHKFIVKMREGYSTVLSDRGEDLSE
                     GQKQLISIARAVLKNAPILILDEATSNIDIATEAKIQEAINNLTYGKTSIIIAHRLST
                     ISNCDNIIVLENGRIVESGNHKELIKLKGHYYRNILLTQGK"
     gene            complement(1959..3734)
                     /locus_tag="KRO40_002993"
     CDS             complement(1959..3734)
                     /locus_tag="KRO40_002993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093802.1"
                     /translation="MRYFKKYIKKYIVLFLTAVFFLTLEAFCDLAQPTIMAKIIDIGV
                     SNKNLDYILSTGAIMIGITFLGAIFAIIRSVISARVSQNFSYDLRQDVFEKINTYSLK
                     QIDKFGRASLITRITNDINQMQQFVNGMMRVFIKSPIMCIGSLIIAIKLNLKMSIIIL
                     IAVLIIFIIILLNMKIGYRLFKNVQESTDKVNSKLRQFLSGIKVVKLFCRYDYENQSF
                     EELNDELFKNSRKATTMMSFFRPTITIIINVSIIIILLIGRHLIYSGEIKIGIIVAYV
                     NYMTRILTSLIMISHVFNVFVRAKASYERISEVLVDENEEVIEREESLDVGEKDLKFV
                     NCDIIFENVDFSYNKNTDEKILKNVSFKIEEGQNIGVIGQTGSGKTSLVNLIQKLYII
                     DKGDIKIGGRSIYSISEESLRTRIGVVFQNSSVFGKSILENVVMGNRDICKEDVVKSC
                     EIANANQFITKLENTYDEVLFQRGKNLSGGQRQRITIARAIAKKPQILILDDCFSAMD
                     INTETIIRKNIKEYISNLREKESKKCTVITISQKISSIIDCDKILVLDEGEVVGFATH
                     EDLLVSSPIYKKIFALQNLVSEDVN"
     gene            4027..6255
                     /locus_tag="KRO40_002994"
     CDS             4027..6255
                     /locus_tag="KRO40_002994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="HBH2093803.1"
                     /translation="MRHLKKTNSLKEILNWNNIKNLRPSKGLKNILEIFKSDLKDIRG
                     NYAVLVIVLGLAFLPSLYAWFNIKASWDPYGSTANMLVAVTNEDKGNEIAGQKINVGD
                     QLIEQLKDNKSLGWQFVDEKTALEGVKKGTYYASLKIPKNFTKDLTSLITDDVKKGEI
                     IYTVNEKINAVAPKITDKGASTIQLQVNQTIVKTVSEIVLGISNGVGAGIEHSLPKLT
                     KVENSLIDLQKRFDHINKTVDLASDATSKLSDTVKDIKSDLPTIKKTLNDTKLLSSDL
                     KKFLEDTNDNLDELSPLIKSDLNLMVDLSSSASSLTLNLIDAVNSGSEDVPKLIDNLS
                     EKLSNLQSLNDTLVDFLTKLNQLTSNNRLDDVIDNLEDSSNKIDSSISTLNDIKNKVI
                     SGQQPSISALNNVLSLSNGIGRINLNILNNFDSKISKPINSIFANSIKVANDIITVLD
                     KAEAKLPKVEEILTTSLKLSGNAQESISLIRERLPLAKGMLDDLIDTLSKISNGEDMK
                     KLVSLLESDILTKSNFLKEPVEVKTEKLYPIENYGSAMTPFYSVLSTWVGILLISALL
                     STSVHGNYKPYEIYFGRGLTFLSIALVQGFIIGTGDILLLGVTAKHPILLIVLLMFTS
                     MVFNFIVYSLVSVFGNVGKAIAIVLLVVQIGSSGGTFPIQVTPTFFQRINPIMPFTYA
                     IGATREAVGGIYAPNLTKDILVLLLFMILSICLNVLLKGPINRVIKPFNDKFGDSNLT
                     GH"
     gene            complement(6493..6792)
                     /locus_tag="KRO40_002995"
     CDS             complement(6493..6792)
                     /locus_tag="KRO40_002995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HBH2093804.1"
                     /translation="MYKNINKKQLKEMMKNEKDVLLLDVRTKDEFKEYKIENAINISL
                     QELINNIDEIYDYKDKKVVVYCRSGHRSVTACNLLAEEGFEHLYNLNSGIIDYMS"
     gene            6999..10040
                     /locus_tag="KRO40_002996"
     CDS             6999..10040
                     /locus_tag="KRO40_002996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp20"
                     /protein_id="HBH2093805.1"
                     /translation="MFKQRLSKLLSSTLVLSMLFTAAPNITFADNTKDNSEKYQSSDI
                     ELHDYSKNAESYTKTKALAKEKIQTLLSKYGAVSAQYALIDNGKIEISGNGGVYSKQD
                     NKNLNKDNMYSIASISKMFTTTAVMKLVDDGKLNLDTPVVKYIPEFKMADDRYKEITP
                     RMLLNHSSGLMGSSFKNTILLADNDSYGHDNFLKELQKQRLKAKPGAFSVYCNDGFTL
                     AEILVERVSGMSFTNFLDKYINNPLNLQNTKTPENSFDSSKLAKAYVPYWEDAVPQDN
                     LNAIGAGGLYSSAENLCTFAQTFMKNSNGILSPASVKAMENKEYLNGLWPEGEDSILG
                     YGLGWDCVNTYPFNQYNLKALTKGGDSLLFHSNLIVLPDENMAVAVLSSGGSSQLNEI
                     IGQEILLSALKEKGKIKEIKPDKTFSKPQQVKMPSSLKENSGLYASSNMIKVDVNDNG
                     TLTVSSPYIENGPEDKYVYIGQDRFVSEKGNSCLKFVKEKNNITYLNMSSYDDVPGLG
                     QTASLYYVAQKVDDNNISNSVKEVWKKRSGKGYYLVDEKYTSQSYMFGSVKASFSLSD
                     ETPGYIVNTKIMDENNSNAFIEIPGVIGRDLSDIKLHKENGTEYLSFGTLTYVSEDSI
                     TNLPAEKSFTCELESNGYAKWYKIGDDIANKKIEVNLPQNSAFAVYDDKGVPVNYSLV
                     TKNNRVRLPKGGVIVFLGSPNARFEVTYQDEVNASALTGTDRYETSIKISQAGWENAE
                     NAVLINDSAIADALAATPFAYKKNAPILLTGSSQINEKTLAELKRLKVKNVYVVGGET
                     SINEKSLDTIKSNNISVSRISGSDRYQTSMNIAKELNNISNISKISVVNGEKGLADAV
                     SIGAVSAQNDMPIILTNENSNITEINNLFKNKKIDKSYVIGGEYTVSKNIESKLQNPQ
                     RISGSTRNETNAKVIKEFYKDSKIDNLYVAKNGMNKQDDLIDGLSVGVLAGKTKSPVM
                     LVGNSLDYNQKELFKTMRFKSVTQIGGNGNENSFKQIKEIA"
     gene            complement(10201..11475)
                     /locus_tag="KRO40_002997"
     CDS             complement(10201..11475)
                     /locus_tag="KRO40_002997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2093806.1"
                     /translation="MITISHITAKNMYKSLEERINKFPQGAPPSDTLYKILNVLYTEQ
                     EAKLVAQLPIKPFRVKTAAKIWSVSESEAYRVLDKLASKALILDIEDNKGKKYIMPPP
                     MAGFFEFAMMRTRHDIDQKLLAELYYQYMNVEEDFIKDLFYSTETKLGRVYVQEEVLT
                     NDNEVSILDYERATHIIDESTHIGISMCYCRHRMQHVGKACDAPMDICMTFDNVANSL
                     INNKFARRVDKIECKELLHQAYEHNLVQCGENVRKGVTFICNCCGCCCEAMVAAKRFG
                     NLHPVQTTSFIPNINHENCVKCGKCITACPIDAISKVKEDGKEYIKIDEDRCLGCGVC
                     VRNCHKNSIMLLKRDEKIITPANSVHRAVLMAIEKGQLQNLIFDNNALASHRAMGAIL
                     SAILKLEPAKKILASKQLKSVYLDKLLSMNDK"
BASE COUNT         4133 a         1721 c         1436 g         4284 t
ORIGIN      
        1 ttcataatta ctttcctcct aaattttata tatcaaatta aattttttat ttattaagtt
       61 agtctatata tacccgcacc atataccttt aaacaatttt tttaaaagtt ttttctaaat
      121 acttattttc cctgtgtcaa taatatgttt ctataataat gtccctttaa ttttatcaat
      181 tctttatgat ttcctgattc cacaattcta ccattttcta aaactattat attatcacaa
      241 tttgatatgg tacttaatct atgagctata attatacttg tctttccata agttaaatta
      301 tttattgctt cttgaatttt agcttctgtt gctatatcta tgttacttgt agcctcatcc
      361 aaaataagta ttggagcatt ttttaatact gctctagcaa tacttattaa ttgtttttga
      421 ccttcactta aatcttcacc cctatccgat aatacagtac tatatccttc acgcatttta
      481 actataaatt tatgtgcatt tgctatttta ctagcatata taacttcttc atcagtagcc
      541 tccagatttc cataccttat attttccata actgtatcat tgaatatata accttcttgt
      601 ggaactactc caaaacaagt tctcaaatag tttctgttaa tagagtatat atccttacca
      661 tctaaaaata tacttccttc atctatatga taaaaatttg taattagatt tataattgtt
      721 gtttttccac ttcccgtctc tcctatgatg gcatttgatg tgccagattt gatttttagg
      781 tttatattat ctaaaatttt cttttttgaa tcataagaaa aacttacatc tttaagctca
      841 atttctccct ttacaaaatg agagtttaaa ttaccatctt tattatcgtt aatctcactt
      901 ttaaacatgt tatgcacttc ttgctcttct tgttcatcta taatttcaaa aactctttca
      961 catccagcta tggctgaaag taatgtatta aatagatttg ctaattcatt taaaggtctt
     1021 gtaaattgtc ttacataact taaaaaacta gctataaccc ctatggttat aatatcttta
     1081 gatgcaagaa tgcctcctat aatacatata gttgcaaatc ctatattact aatcacattc
     1141 ataataggca ttaaaagaga agtgtaaatt tgcgatttaa gggaaatatt tagaagtcta
     1201 tcattgactt ctttaaaatc atttacagat tttctttcat aattaaaaga ttttactaca
     1261 tttatgtttg atatcatttc ttcaatatgt gcatttagtt ttcccaactc aacttgttgt
     1321 tgcttaaaaa aaactctagt tctctttgca ataaaattac tcacaaacat tactatcggt
     1381 attaatatta cactgcaaaa ggttaaaatt gggcttaata caaacatcat aataaaagtc
     1441 atcaatatgt ttaagattcc tgtaattaac tgtactaatg aatttgatat tcctgtactg
     1501 atattatcaa catcatttgt cactctactc ataatatctc cagtagaact tttatcaaaa
     1561 aaggttattg gtagattttt aaattttaaa aataaattac ttctcatttc tttaactata
     1621 ctttgagata atctagctgt acatatcccc ttagacagtt taactgaaaa ctcaattata
     1681 taaaatgaaa gtaaaataat tattcctttt aagaaaatgg attttgaata agtatcgata
     1741 tctattatgt caactacctt tccaatagta tatggtatta cagttgatat aattgaatca
     1801 attattaata gcaaaaaaat aaatctagta atcttcttat cttttttaaa gtacataaaa
     1861 attcttttaa acgttttttt aaaatcttta ggcttttctt ttttctttaa tctactgacc
     1921 ttctgatttc cagtacttaa attcaatata cttcctcctt aatttacatc ttcacttact
     1981 aaattttgca acgcaaaaat ttttttataa attggagaac taaccagtaa atcttcatgt
     2041 gtagcaaatc caaccacctc accctcatcc aagactaaaa tcttatcaca gtcaattata
     2101 gaactaatct tttgtgaaat agttattaca gtacatttct tactttcctt ttctcttaaa
     2161 ttacttatat actcttttat attctttctt ataattgtct ctgtattaat atccattgca
     2221 ctaaaacaat catcaagaat taatatttgt ggttttttgg ctatagctct agctatagta
     2281 attctttgtc tctgtcctcc tgataaattt ttaccccttt ggaataaaac ttcatcataa
     2341 gtattttcga gttttgttat aaattgattt gcatttgcta tttcacatga ttttacaaca
     2401 tcttctttgc atatatctct atttcccata actacattct ccaatatact ttttccaaac
     2461 acactactat tttgaaatac tacacctatt cttgtcctta aactttcttc agaaatactg
     2521 tatatactac gtcctccaat cttaatatca cctttatcaa ttatatataa tttttgaatt
     2581 aaatttacta aagaagtctt tcctgaacca gtttgaccaa tcacaccaat attttgacct
     2641 tcttctattt taaaggatac gttttttaat attttttcat ctgtattttt gttatacgaa
     2701 aaatctacat tttcaaaaat tatatcacaa tttacaaact ttaaatcttt ttctccaaca
     2761 tctaaacttt cttctctctc aattacttct tcattctcat caaccaaaac ctcacttatt
     2821 ctctcataag atgcttttgc cctaacaaaa acattaaaaa catgtgaaat cattataaga
     2881 gatgttaata ttctagtcat atagtttaca taagcaacta taatcccaat tttaatttct
     2941 cctgaataaa ttaaatgcct tccaattagt aatattatta ttatggaaac attaatgatt
     3001 attgtaattg tcggtctaaa aaatgacatc atagttgtag cttttctact atttttaaaa
     3061 agttcatcat ttaactcttc aaagctttgg ttctcataat cgtatctaca aaatagttta
     3121 actactttta ttccacttaa aaactgtctt aattttgaat ttactttatc tgtactttct
     3181 tgtacatttt taaataatct ataccctatc ttcatattaa gcaatattat aataaatata
     3241 attaaaactg caattagaat aattattgac atctttaaat ttaattttat agctataatt
     3301 aaacttccta tacacattat tggtgacttt ataaaaactc tcatcattcc attaacgaat
     3361 tgttgcattt gattgatatc attagtaatt cttgttatta atgaagctct accaaattta
     3421 tctatttgtt ttaatgagta tgtatttatc ttttcaaata catcctgtct taaatcataa
     3481 gaaaaattct gagaaactct tgccgagatt acacttctta ttattgcaaa tattgcacct
     3541 aaaaaagtta tacctatcat tatagctcct gttgatagta tgtagtctaa gttcttattt
     3601 gaaaccccta tatctattat ttttgccatt atagttggtt gagctaaatc acaaaaagct
     3661 tccaatgtta aaaaaaatac tgctgttaga aataatacta tatatttttt tatgtatttt
     3721 ttaaaatacc tcattcaatc atcccttcat agaattttct cattaccaaa agtatatcat
     3781 aatggctaat ttaattgatt atatcaatta taaatatttg atttattatt aatttttata
     3841 ccatatattt tataaattat ttgtttttat ttcctatatt tatatatatt tatagcatac
     3901 tattatatat aatatatatg tattaaaatt aagacaaaat tttaacttta ctatttgtgt
     3961 aaaaagtaat ataatttaaa attgattata aatctaactt ttttctttat caaaatattt
     4021 taggaggtga gacatttgaa aaaaactaat agtttaaaag aaattttaaa ctggaataat
     4081 atcaagaatt taagaccttc aaagggttta aaaaatatat tagaaatttt taaaagtgac
     4141 ctaaaagata tacgtggcaa ttatgccgta cttgtaatag ttttaggtct tgctttttta
     4201 ccatctctgt atgcttggtt caatataaag gcatcttggg acccttatgg aagcactgcc
     4261 aatatgcttg tagcagtaac aaatgaagat aaaggaaatg aaatagcagg gcaaaagatt
     4321 aatgtaggag accaattaat tgaacaactc aaagataaca agagtttagg ttggcaattt
     4381 gtagatgaaa aaactgctct tgaaggtgtt aaaaaaggta cttattatgc atcacttaag
     4441 attccaaaaa attttacaaa agatttgaca tctttaatta cagatgatgt taaaaaaggc
     4501 gaaattatct atactgttaa tgaaaaaata aatgcagttg caccaaagat tacagataaa
     4561 ggtgcttcta caatacaact acaggttaat cagactatag taaaaacagt tagtgaaatc
     4621 gttcttggta tatcaaacgg agttggtgca ggaattgaac acagtcttcc aaaattgaca
     4681 aaagttgaaa attcccttat tgaccttcaa aagagatttg accatataaa taagactgtt
     4741 gatttagctt ctgatgctac ttcaaaatta tctgatacag ttaaagatat taaatctgat
     4801 ttacctacaa ttaaaaaaac tctgaatgat acaaaactat tatcaagtga cttaaaaaaa
     4861 ttcttagagg atacaaatga taatttagac gaactttctc ctcttattaa gtctgactta
     4921 aatttaatgg ttgacctttc atcttctgct tcttctctta cattaaattt aattgatgca
     4981 gtaaatagtg gcagtgaaga tgtacctaag ttgatagata atttatcaga aaaactttct
     5041 aatttgcaat ctttaaatga tactttggtg gattttttaa ctaaattaaa ccaacttaca
     5101 tcaaataata gattggatga tgtcatagat aatcttgaag actctagcaa taaaatagat
     5161 tcatctatat caacattaaa tgatattaaa aacaaagtta tatctggaca acaaccatct
     5221 ataagtgctt tgaataatgt tttaagtcta tcaaatggta ttggaagaat taatttaaat
     5281 attttaaata attttgactc aaaaatatca aaacctataa atagtatatt tgcaaacagt
     5341 ataaaagtag caaatgatat aattactgtt ttagataagg cagaagcaaa acttccaaag
     5401 gttgaagaaa tacttactac ttctctaaaa ctttcaggaa atgcacagga aagtatatca
     5461 ttgataagag aaagacttcc tttagcaaaa ggaatgttgg atgatttgat tgatacttta
     5521 agcaaaatta gtaatggtga agatatgaaa aaattagtca gcttgcttga aagtgatata
     5581 ttgacaaagt ctaatttctt aaaagaacct gttgaggtga aaacagagaa attatatcca
     5641 attgaaaatt atggttctgc aatgacacca ttttatagtg ttctttctac atgggttggt
     5701 atattactta tttcagcact attgtctaca tctgtacatg gaaactataa accttatgaa
     5761 atttactttg gaagaggcct tactttttta agtatagctc ttgtccaagg ttttataata
     5821 ggaactggag atatattatt gttaggagta acagcaaaac atccaatttt attgatagtt
     5881 ctgcttatgt ttactagtat ggtatttaac tttatagtgt attctttagt ttctgtattt
     5941 ggaaatgtag gaaaagcaat tgcaatagta ctattagtcg ttcagattgg ttcttctggt
     6001 ggtacattcc ctatacaagt tacacctaca ttcttccaaa gaataaaccc tataatgcca
     6061 tttacctatg caataggtgc tacaagggaa gcagttggtg gtatatatgc tccaaatcta
     6121 actaaagata tactagttct attactattt atgattctgt ctatttgttt aaacgtactt
     6181 ctaaaaggac ctataaatag agttataaaa ccatttaatg ataaatttgg cgatagtaat
     6241 ttaactggtc attaaaaaat taattctgtc tttaaatata tttttttaat aatattctaa
     6301 gttaatatta aaaggtagta gctaaaaagc tactaccttt ttccaactta aaaactaata
     6361 tttactacaa aaactgtcat agaaaaaaac gaaaaaattc gttctttcct aaatttatct
     6421 tataaatatt tagatatatt cctacttaat aagcagagct atacatagta tttaatgtat
     6481 aatttacatt atttaactca tataatcaat tattcctgag tttaaattat ataaatgctc
     6541 aaaaccttct tcagctaaca aattacatgc agtaacactt ctatgaccac ttctgcaata
     6601 aactactact ttcttatctt tataatcgta aatttcatct atattattga ttaactcttg
     6661 taaagatata tttatagcat tttctatttt atattcctta aattcatctt tagttcttac
     6721 atctaataat aaaacatcct tttcattttt catcatttct ttaagttgct tcttatttat
     6781 attcttatac atatgtctaa aattcctcca ttttatttat atattaccta taccctttat
     6841 tctttataca acaacaaata ttatttttat atttttctct gttatataaa aagctatact
     6901 tataaaagct ttttttattg ataataatct gttgattaaa ataattaaga atgttatgct
     6961 aattataaat tattaaaaag ggaaagaggt aatgtaatat gtttaagcaa aggctctcta
     7021 aattattatc tagtacatta gtattgagta tgttatttac tgctgctcca aatattactt
     7081 ttgctgataa tacaaaagat aattccgaaa aatatcaaag ttctgatata gaattacatg
     7141 attatagtaa aaacgcggaa tcttacacaa aaactaaagc tcttgctaaa gagaaaatcc
     7201 aaactttgct atcaaagtat ggtgctgtaa gtgctcaata tgctttgatt gataatggca
     7261 aaattgagat ttctggtaat ggtggcgttt acagcaaaca ggataacaaa aacttaaata
     7321 aggataatat gtatagtatc gcatctatca gtaaaatgtt tactacaaca gctgttatga
     7381 agttggttga tgatggaaaa ttaaatttag atactcctgt tgtaaagtat atacctgaat
     7441 ttaaaatggc tgatgataga tacaaggaaa tcactccaag aatgttatta aatcattcat
     7501 cagggttgat gggaagtagt tttaaaaaca ctattttatt agcagacaat gattcttatg
     7561 gtcatgataa tttcttaaaa gaattacaaa aacaaagatt aaaagctaaa ccaggagctt
     7621 tttctgttta ttgtaatgat ggatttactt tagctgaaat tttagtagaa agagtatctg
     7681 gtatgtcatt tactaatttt cttgataaat acataaataa tccacttaac ttacaaaata
     7741 caaaaactcc agaaaatagt tttgatagtt caaaactagc aaaagcatat gtaccttatt
     7801 gggaagatgc agttccacaa gataacctta atgctatagg tgcaggtggt ttatattcaa
     7861 gtgcagaaaa tctatgtaca tttgcacaaa catttatgaa aaattcaaat ggtattcttt
     7921 ctcctgcttc agtaaaagct atggaaaaca aagaatattt aaatggtcta tggcctgaag
     7981 gagaagactc tatacttgga tatggtttag ggtgggattg tgtcaacact tatccattta
     8041 atcagtataa tttaaaagct cttacaaaag gtggagattc tttattattc cacagtaatc
     8101 ttatagttct tccagatgaa aatatggcag ttgcagttct ttcttctggt ggaagtagtc
     8161 aacttaatga aataattgga caagaaatct tactatctgc attaaaagaa aaaggtaaaa
     8221 ttaaagaaat aaaacctgat aaaacattta gtaagccaca acaagttaaa atgcctagct
     8281 ctttaaaaga aaatagtggt ctttatgctt cttcaaatat gataaaagta gatgttaatg
     8341 ataatggtac tttaacagta tcttctcctt atatagaaaa tggacctgaa gataaatacg
     8401 tatacatagg tcaagataga tttgtatctg aaaaaggtaa tagttgttta aaatttgtaa
     8461 aagaaaaaaa taatatcaca tatttaaata tgagctctta tgatgatgtc cctggattag
     8521 gtcagacagc aagtttatac tatgtagctc aaaaagtaga tgacaacaat atatcaaata
     8581 gtgtcaaaga agtgtggaaa aaaagaagtg gcaaaggtta ctatctagtg gatgaaaaat
     8641 atacttctca aagctatatg tttggctctg taaaagcaag ttttagtctt tctgatgaaa
     8701 ctccaggtta tatagttaac actaaaataa tggatgagaa taactcaaat gcttttatag
     8761 aaatacctgg tgtaataggt cgtgatttat ccgacattaa acttcataaa gaaaatggta
     8821 cagagtattt atcttttgga acactaacgt atgttagtga agattctata actaatttgc
     8881 cagcagaaaa atcttttact tgtgaactag aatccaatgg ttatgcaaaa tggtataaga
     8941 ttggtgacga tatcgcaaat aaaaaaatag aagttaatct tcctcaaaat tcagcttttg
     9001 ctgtttatga tgataaaggt gttcctgtaa actattcttt agttacaaag aacaatagag
     9061 ttagattgcc aaaaggaggc gtaattgttt tcttaggaag tccaaatgct agatttgagg
     9121 ttacatatca agatgaagta aatgcaagtg cacttacagg aactgataga tatgaaactt
     9181 ctattaagat aagtcaagca ggttgggaaa atgctgaaaa tgcagtttta ataaacgatt
     9241 cagcaattgc agatgctttg gctgcaacac catttgcata caagaaaaac gctcctatat
     9301 tattgactgg aagctctcaa ataaatgaaa aaactttggc tgaattaaag agattaaaag
     9361 ttaaaaatgt atatgtagtt ggtggagaaa cttctataaa tgaaaaatct ttagatacta
     9421 taaaatcaaa caatatctct gtatctagaa tttcaggaag tgatagatat caaacttcta
     9481 tgaacattgc taaagaattg aacaatatta gcaatatatc aaagatttca gtagttaatg
     9541 gcgaaaaagg attagccgat gcagtaagca ttggagctgt atcagctcaa aatgatatgc
     9601 ctataatact tactaatgaa aatagtaata taactgaaat aaataacttg tttaaaaaca
     9661 aaaagattga taaatcttat gtaatcggtg gagaatatac agtttctaaa aatatagaaa
     9721 gtaaacttca aaatccacag agaatatcag gtagcactag aaatgaaact aatgcaaaag
     9781 taataaaaga attttacaag gattctaaga tagacaattt atatgttgct aaaaatggaa
     9841 tgaataaaca agatgattta atagacggat tatctgttgg agttttggct ggaaaaacta
     9901 aatctcctgt aatgctagta ggaaactcac tagattataa tcaaaaagaa ctatttaaaa
     9961 ctatgagatt taaatctgta acacaaattg gtggaaatgg aaatgaaaac tcatttaagc
    10021 aaataaaaga aatagcttaa cataactaaa aaaggctgta ttcaagtaat attaattgaa
    10081 tatagccttt ttttatttaa gttataagtt ttatatgtgt aaaaattaaa tttaaatatt
    10141 aaatgataag tttattaaga tatagataag tctaaaactt tgcctttttt aagttagttt
    10201 ctatttatca ttcatactta acaatttatc taaatatact gactttaatt gtttactggc
    10261 taaaatcttt ttagctggtt caagctttaa tatagctgac agtatagctc ccatagctct
    10321 atgactagcc agagcattat tatcaaaaat taaattttgt aactgccctt tttcaattgc
    10381 cataagaact gctctatgta ctgaatttgc tggagttatt attttttcat ctctctttaa
    10441 taacataatg ctatttttat ggcaatttct aacacaaact ccacaaccta gacatctatc
    10501 ctcatcaatt tttatatatt ctttaccatc ttccttaacc ttgcttatcg catctattgg
    10561 acatgcagtt atacatttac cacactttac acaattttca tggtttatat ttggtataaa
    10621 acttgttgtc tgtactggat gaagatttcc aaatctttta gctgctacca ttgcttcaca
    10681 gcaacatcca cagcaattac atataaacgt aacccctttc ctaacatttt ctccacattg
    10741 aactaagtta tgttcatatg cttgatgaag tagttcttta cattctattt tatccacacg
    10801 tcttgcaaat ttattattta ttaaagaatt tgctacattg tcaaacgtca tacatatatc
    10861 cataggagca tcacaagctt ttccaacatg ttgcattcta tgtctacagt aacacatact
    10921 tatacctata tgagttgatt catcaattat atgagtagcc ctttcataat ctaaaatact
    10981 aacctcatta tcattagtta aaacttcctc ttgaacgtat actcttccaa gcttcgtttc
    11041 tgttgaataa aataaatctt tgataaaatc ttcttctaca ttcatatatt gatagtaaag
    11101 ctctgccaaa agtttttggt ctatatcgtg tctcgttctc atcatggcaa actcaaaaaa
    11161 accagccatt ggaggaggca ttatatattt cttcccttta ttatcttcta tatctagtat
    11221 cagagcctta ctagcaagtt tatccaatac tctatatgct tcactttcac ttacactcca
    11281 aattttagct gctgttttta ctctgaaagg ctttattgga agctgagcaa ctaacttcgc
    11341 ttcttgttct gtatatagta catttagtat tttgtataat gtatcagatg gtggagcacc
    11401 ttgtggaaac ttgtttattc tttcctctaa acttttatac atattcttcg cagttatatg
    11461 agaaatagta atcaccttct ttttcttttg ttttccaata aaatcaaata ttctttctta
    11521 ttatatattc tcttacttta tataatacca attctttcta aatagttaaa tacc
//
LOCUS       DAEQCW010000113        11156 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.114, whole genome shotgun sequence.
ACCESSION   DAEQCW010000113 DAEQCW010000000
VERSION     DAEQCW010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11156)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11156)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11156
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.114"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(3..635)
                     /locus_tag="KRO40_002998"
     CDS             complement(3..635)
                     /locus_tag="KRO40_002998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBH2093807.1"
                     /translation="MTIPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYND
                     PRDFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEW
                     KLDINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSI
                     VGGVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
     gene            complement(707..1060)
                     /locus_tag="KRO40_002999"
     CDS             complement(707..1060)
                     /locus_tag="KRO40_002999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase DNA-binding domain-containing protein"
                     /protein_id="HBH2093808.1"
                     /translation="MSTEKRRDNKDRILRTGESQRKDGRYAYKYVYSFGKAQFVYSWK
                     LVPTDKPPKGKRDDISLRDKEKAIQNDLDDSIDTIGKKMTVCQLYAKKNVLRKNIRLN
                     TKKGRHYLMKILNKE"
     gene            complement(1138..1341)
                     /locus_tag="KRO40_003000"
                     /pseudo
     CDS             complement(1138..1341)
                     /locus_tag="KRO40_003000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
     gene            complement(1731..1961)
                     /locus_tag="KRO40_003001"
     CDS             complement(1731..1961)
                     /locus_tag="KRO40_003001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093809.1"
                     /translation="MKPTKEVLPFTIILLAVHGDVNAINVILKHFEHYIIRLSQKTLF
                     DEYGNPYIHVEEETKRMLGTKLITAILRFNLS"
     gene            complement(1963..2370)
                     /locus_tag="KRO40_003002"
     CDS             complement(1963..2370)
                     /locus_tag="KRO40_003002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBH2093810.1"
                     /translation="MVDEKTIEHQFDSFCKTVLRNYARDIYDENKRRNDYLVSLESLS
                     LAELSKLSILDDYDSNYICMVSYDYNIRIEDVLMAQAIGKLTKRKQDIILLSFFLNMT
                     NADIATLMDLAENTIHYHKTNALKELKELMQEH"
     gene            complement(2731..3169)
                     /locus_tag="KRO40_003003"
                     /pseudo
     CDS             complement(2731..3169)
                     /locus_tag="KRO40_003003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729090.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(3183..4109)
                     /locus_tag="KRO40_003004"
     CDS             complement(3183..4109)
                     /locus_tag="KRO40_003004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093811.1"
                     /translation="MSDILSRITNKIGDKNIVDKLSALSKSDLNSLLLEVFDRQANTL
                     TATDILKSYQLNRFTIPSGIDPEEIHALESKLLRKAFNMDIKTIMLSPSAPLGSCSVF
                     GSVDQYNVVSALRGTETLADPSNMLAIIIADKLKRKEENNTIPIHMATTARVIRAQNF
                     VGKGLYSHFGLYCMVSSGIDTGSYTCEKMLLEKHLNYYKDILSEIENVRFSIILRKRN
                     GYKDNDGFFDRMVETIKLIFPNIELSIHNDDVDNNYYKGINFKLSVKQGNETVEIVDG
                     GFVDWTYQMLGNKKERCLISGIGLERFLVAVS"
     gene            complement(4234..5016)
                     /locus_tag="KRO40_003005"
     CDS             complement(4234..5016)
                     /locus_tag="KRO40_003005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /protein_id="HBH2093812.1"
                     /translation="MTKTQQEMIQNVLEFSKRDSRIIGLAISGSYITKSLDEYSDLDF
                     LIVADDKSYEEVIEERLLIVEQFGTLVSAFTGEHVGEPRLIISLYDSPVLHVDFKFTT
                     LDGLLDRVEDSAILYEENNCITEIYSKKEAYFPTPDLQWIEDRFWIWVHYTCTKIGRR
                     ELFETIDFLSFLRQSVLASLIQLLLGKLPRGVRKIELDAPQYIEALEKTVANHEYKSC
                     VNALQATINLYLELREELSQSPIVRKVEAERVALQYFQDLIK"
     gene            complement(5172..5792)
                     /locus_tag="KRO40_003006"
     CDS             complement(5172..5792)
                     /locus_tag="KRO40_003006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH2093813.1"
                     /translation="MHLIDFMNEDIKKKLVKKTYKKKETILFAEQENEYVILMIDGIA
                     EAFILNVKGNISTIHLYRSGSFFGEMEQFNDGKKPVEIVAFTDCNVYKLHRDDFLNWL
                     RGDFEATKFLIREISSKLVVNAELIEELSSLSVKERLLRCISLHYYRSELNLLTKKQL
                     ASEVNAPIRSINRAINECVQEHLIAYENKRFSVINQREVLKNLPTT"
     gene            complement(5919..6587)
                     /locus_tag="KRO40_003007"
                     /pseudo
     CDS             complement(5919..6587)
                     /locus_tag="KRO40_003007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331151.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            6679..7494
                     /locus_tag="KRO40_003008"
                     /pseudo
     CDS             6679..7494
                     /locus_tag="KRO40_003008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897377.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            8165..8932
                     /locus_tag="KRO40_003009"
     CDS             8165..8932
                     /locus_tag="KRO40_003009"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HBH2093814.1"
                     /translation="MKRKVQVKNITIGEGRPKICVPIIGKNKKDIIKEAKELKDACLD
                     IIEWRVDFFENVENIKEVKEVLYELRSYIHDIPLLFTFRSVVEGGEKLISRDYYTTLN
                     KEISNTGLVDLIDVELFMGDEVIDEVVNFAHKKEVKVIISNHDFNKTPKKEEIVSRLC
                     RMQELGADLPKIAVMPQNEKDVLVLLEATNEMFKIYADRPIITMSMSGMGVISRLCGE
                     IFGSALTFGAAKSVSAPGQISFKELNSVLNLLHKSIN"
     gene            complement(9265..9942)
                     /locus_tag="KRO40_003010"
     CDS             complement(9265..9942)
                     /locus_tag="KRO40_003010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093815.1"
                     /translation="MIVIEGSDKFKIAKEYIDVEYTLFSKVTFRYEKLKFKDNAELEK
                     IKMFKYKNGYIPNKLNLSFGYGFSSYKKQIIRETVDTLRLTEIFSSENIEDIKFIKDG
                     TKKLEISIEKVVKFKRRKKRNYVCCYCPDMYRDIKLDKESINKIYNRKIKIEREVNIF
                     EDEDVIINKKVLKFPKSWTKNMQKYWLSENKYPIHSTVIDDDRYKCCNVQYTKNRVII
                     LYYIYNH"
     gene            complement(10092..10409)
                     /locus_tag="KRO40_003011"
     CDS             complement(10092..10409)
                     /locus_tag="KRO40_003011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093816.1"
                     /translation="MNYIGKRLKEERKKANLTSKEFANMVGVSPWYITQIESGKKNPS
                     LKTFIKFVNILNISADVLIKDITSTGKTYLENDINEELKDLNSRELNLISQIIDIIKK
                     NKI"
     gene            complement(10431..10769)
                     /locus_tag="KRO40_003012"
     CDS             complement(10431..10769)
                     /locus_tag="KRO40_003012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093817.1"
                     /translation="MANIGKIIGDRIKVYRTKLGYSQEFLAEKAGLHPTYIGQIERAE
                     TNTSINIIMKIATALDIPLELLFANIITTEGVDNSVPLECYEMINKLTEKEQIAMLEL
                     IKCIIKYKEI"
BASE COUNT         3723 a         1736 c         1574 g         4123 t
ORIGIN      
        1 tattaaacta atttatcaat atttcctgat tgaatatgct taatgtttga ttgaattttt
       61 ttatatggcc aatcccacca tttaatttct aataattttg aaattgtatc attattaaat
      121 ctctttttta taatttttgc aggtactcct ccaacaatag aatacggtgg aacgtcatta
      181 gtaactactg ctcttgttcc aataattgca ccatcaccaa tatttacacc tgacataatt
      241 atagaatcat aacctatcca cacatcattt ccaattataa tgttaccctt attgtcccaa
      301 gcgtccgtta tatggttgat atcgagtttc cattcttcat aaaagatggg aaaagtatat
      361 gtggattttg atttcattga gtgatttcca ctagtcatta gaaattttgc attacatgct
      421 attgagcaaa acttaccaat tattaattta tcattgttta tagggtaatg atacaataca
      481 ttgtttttct caaaatctct tgggtcatta taaaagtcat tatatattgt gtaatctcca
      541 acttctatat tttcccttgt tattacattt ttaagatata cagtttgata atcattactt
      601 cttggatata ccttatttga acttggaata gtcatattta aatctctcct ttaatatata
      661 ttatgttttt gactattcca ctactacaat acatctcttc acagaatcac tccttgttaa
      721 gaatcttcat aagataatgg cgtccttttt tagtgttaag tcggatattc tttcttagta
      781 cattcttttt agcgtataac tgacaaactg tcattttctt accaatagtg tcaatgctat
      841 catcaaggtc attttgtatt gctttttcct tatcccttaa tgatatatca tcacgttttc
      901 cctttggggg tttatcagta ggtacaagtt tccaagagta aacaaattgt gctttaccaa
      961 atgaatatac atacttatat gcgtatcttc catcttttct ctggctctct ccagttctta
     1021 aaattctatc tttattatct cgtctttttt cagttgacat gataagaagc tcctctcaat
     1081 aaccgaattg agcttgatac gtcatatgaa tattataaca tataaggctc aatttcatta
     1141 gataacgtca agtgtatcaa cgattttctc aaattgtttt ctctttattt gaatgcgatt
     1201 gctattcata atgacccagc cagaatcaag gttttcatca gcaagtttac gtaatttttt
     1261 ctctccaata cgaaagtatt ttgacgctta ttcaatcgtc aaggtatatt tttcccaaat
     1321 aggtacatca gtattgttca tagaatgtat cactcctttc tatgttcgta gttcagaagt
     1381 agatagatgg ctttggtaag ctccattggt atttcaacca atcccattct tatgggcaga
     1441 accgtgtcat acaggtgtat cattatactg tggtacaggt tacggcaaaa caaccgttcc
     1501 aaaggttatt cacaaatcac tatatagtag ctctcttgat taaggtcatg gcgtatagta
     1561 tttgttggct atctgtatca caaacgtatc tatctacttt attcagttgt caaagaacag
     1621 tcggcattga tttgcctata aaaaatcaca atagcttatg ggcttttata gacaaataat
     1681 tagtgattct ccatgtacca aatagcttga tacatggaga gagggcgaga ttaagacaaa
     1741 ttaaatctca aaatagcagt gattagtttt gttcctagca ttcgctttgt ttcttcttct
     1801 acatgaatat agggatttcc gtattcatca aataaagttt tctgtgaaag acgaatgata
     1861 tagtgttcaa aatgtttaag tattacgttt attgcattta catcgccatg tacagcaagt
     1921 aaaataattg taaaaggtaa tacttcttta gtaggtttca tttcaatgtt cctgcatgag
     1981 ttctttcaac tcttttagtg catttgtttt gtgataatgt atggtatttt ctgctaaatc
     2041 catcaatgtt gctatgtcag catttgtcat gttgagaaag aatgaaagta gaattatatc
     2101 ttgttttctt tttgtaagtt ttccgattgc ttgtgccatt aatacatctt caattcgtat
     2161 gttgtagtcg taagaaacca tacagatgta gttagaatca taatcatcta aaatactcaa
     2221 tttacttaat tctgcaagtg acaaagattc gagagatacc aaataatcat ttctgcgttt
     2281 attttcgtca taaatatctc tagcatagtt acgcaaaact gttttacaga aactgtcgaa
     2341 ttgatgttca attgtctttt catcaaccat aagatttcac cctctttcca tcgcaaggag
     2401 ttaaataacc ttgcttactc ctatcacggt gggagggcgt taaatcttcg ataaatttca
     2461 aaaaaaaaga gaaaaaaata cacactctgc ctatagggca aaaatgtgta ttctttaaaa
     2521 cgtatttaat ttatattggt tgtaagccac caccatattg atgtatggaa atatgcattg
     2581 gctagctttt cataaaaata caaagatgca taagaaatta atagagggga aaaacttatt
     2641 ctgttattaa aaagtaggtt aattctaata aatgctattg cggtcgaatt aaactatata
     2701 catggcaatc aatcatgttt ctattcttta ttatgaattg tgacagtatt cttcaatctt
     2761 aaagccacat tttacttgac tctctattgt aggaatatac attagcatga attttgttaa
     2821 ggttgtattt ttcaaaggca attttgcata tttcttttac tgcatttgtt gctatccctt
     2881 tgccccaata gttcctagca agtcagtaac ctaattcagc atttttatta atagaggtat
     2941 cttcttcaaa tgttaggctg atacttccaa tagccctttc ttgataaaaa atagcatagc
     3001 taagttgttt aacatctgaa gttgtcaaac aaaaactaat aaaatctcta gcgttttgct
     3061 acctataagg gtgggggaag ttgtcacgaa gattgtttgc aatttcttta tcattcgcaa
     3121 actcaactaa atcggtaata taagcataat tccactctat aagttccatt tttcttctcc
     3181 ttttatgaaa cagctacaag aaatctttct aagccaatac cacttatcaa acagcgttct
     3241 tttttatttc caagcatttg ataagtccag tcaacaaatc caccgtcaac tatttcaacg
     3301 gtttcatttc cttgtttgac cgataatttg aaattgatac ctttataata attattatca
     3361 acatcatcat tatgaattga taactctata ttaggaaaaa taagtttgat agtttcaacc
     3421 attctgtcga aaaatccgtc attatctttg tatccgtttc ttttgcgtag aataatagag
     3481 aaacgaacat tttctatttc acttaatata tctttataat agtttaagtg cttttctaac
     3541 aacatttttt cacaagtgta agaccctgta tctataccag atgaaaccat acaatataag
     3601 ccaaaatgtg aatataaacc tttacctaca aaattttgtg ctcttattac cctagcagta
     3661 gtagccatgt ggataggtat ggtattattt tcttcttttc tttttaattt atcagcaata
     3721 attattgcca acatatttga ggggtctgca agtgtttctg tccctcgtag agcacttact
     3781 acattatatt gatctacgga gccaaaaacg ctacagctac ctaatggagc agagggagaa
     3841 agcataatcg tcttgatatc catattgaat gcttttctca ataattttga ctccaaagca
     3901 tgaatttctt ctggatctat accgctaggg atagtaaatc tatttagttg gtatgacttt
     3961 agaatatcag ttgcagttaa agtatttgct tgtctatcaa acacttctaa tagaagtgag
     4021 ttcaaatctg attttgatag agctgataac ttatcaacta tattcttatc cccaatttta
     4081 tttgtaattc tacttaaaat atcactcata gttatcctcc atactgttac tttcaaaata
     4141 attatagaat tgttacaaca actaatctag gtcatttgac caaaaatgaa aaaacactga
     4201 atatttacta ttcaatattt ttttactttg ggtttatttg attaaatctt gaaaatactg
     4261 taatgcaacc ctttcagctt caacctttcg gacaatagga ctttgtgata attcctctct
     4321 taattcaaga tacaggttga tagtagcctg caatgcatta acacagcttt tatattcatg
     4381 gttagcaacc gtcttttcta atgcttcaat atattggggt gcgtccaatt caatttttct
     4441 aactccacga ggtaatttac ctaagagaag ctgtattaac gaggcaagta ctgattgtct
     4501 taaaaaagat aaaaaatcaa ttgtttcaaa tagttctcta cgtccaatct tagtgcaagt
     4561 gtaatgaacc caaatccaaa atctatcttc aatccactgt aagtctggag ttgggaagta
     4621 tgcttctttt ttagaataaa tttctgttat gcagttgttt tcttcataga gaatagctga
     4681 atcttcaacc ctatctagta aaccatctaa ggttgtaaac ttaaaatcaa catgaagaac
     4741 aggggaatca tagagggaaa ttatcaatcg aggttctcca acatgttcgc cagtaaaagc
     4801 agaaactaat gttccaaact gttccacaat aagtaatctc tcttcgataa cttcttcata
     4861 ggatttatca tctgctacaa tcagaaaatc caaatcagaa tattcatcta acgattttgt
     4921 gatataagaa ccgctaattg caagtcctat tatcctacta tctctttttg aaaattctaa
     4981 tacgttttgt atcatttcct gttgtgtttt agtcataata taacacctct cactgtcttt
     5041 tattagctat caatccaaca taattatgca taggagtatt atataatgaa gaaataaaaa
     5101 aaaataggtc acttgacccg aaataaaaaa gtattgaata attattatcc aatacttttt
     5161 tgaaattata cttatgttgt aggaagattc tttaatacct ctcgctgatt aattacactg
     5221 aatcttttgt tttcataagc aattagatgt tcttgtacac attcatttat agcacgatta
     5281 atgcttctaa tcggagcgtt tacttcgcta gcaagctgtt ttttggtaag cagatttaat
     5341 tcacttctat aatagtgtaa ggatatacac ctcagaagtc gttctttaac acttaaagat
     5401 gataattctt caattaattc agcatttaca actaatttac tagatatttc tcgaatcaga
     5461 aattttgtag cttcaaaatc tccccttaac cagtttaaaa aatcatctct atgaagttta
     5521 tatacattac aatctgtgaa agcgacaatt tcaacgggtt ttttcccatc attaaattgt
     5581 tccatttctc caaaaaaact accacttcta taaagatgaa tagttgagat gtttcctttc
     5641 acatttaaga tgaatgcttc tgcaataccg tcaatcataa gaattacata ttcattttct
     5701 tgctcagcaa aaagaatagt ctctttcttt ttatacgttt ttttaacaag cttcttttta
     5761 atatcttcat tcataaaatc aattaaatgc atattcatct ctccttacca aatctttgat
     5821 taaattatat catctttcaa ttagttaggt aagatagtaa aaatatattt acatagaaac
     5881 tattccatta ttattttcca gttgtcattt ttctgcaaaa acttatcact gtcacgactg
     5941 gagataccag taaggaatgt taggatatca atcgctaaac tttcagaatc ctttttacgg
     6001 ctcaaaatga cgtaatggtc aagcaatcct ttgttttcat catcactggt taaattgaca
     6061 atgtttatct catgggctat ttctggtagc gtttctttcc atttgccgcg ttttgcttta
     6121 gggtcaacta tgaccgcttg tccgccgaat agtaccgcat agtaaacaag catattgtta
     6181 ctgaataatt taccaccacc caatgaaccg ataaacgcag acgctaacgc attggtaata
     6241 gaacccttta ccccttgact agcaagggca ggttttagat agacattctt tccagtgtcc
     6301 agattgtagc caagatagat atcctcatgt tcgccaaggg tttgtgtcgc tccaaaacca
     6361 agtccagcca aaaaatccga agtgacatat tgaatataat cattgatgta acgtttgctg
     6421 acaggaataa attcgccatg caatcccaac atatccccaa agggacgcac gagcttgatt
     6481 gataagtcgt cgtaaaagtc tttgacttca tcacaacgcc tttttagctc gtcaagatcc
     6541 tttgtagata cacggacaac atagctaagt ttatacatag attctttaca gttaaaagtc
     6601 tctttttaaa aaaatgtata aattataaat caaaatatag atactatcaa tgacccacta
     6661 ggtgcaaaaa gcattgatat ggttaaatta tcagacgcta aaagctgggc tatccgaatg
     6721 agtgaagatg ggtgtgctta taaatccatt gacaattata agcgctcact gaaagcgtcg
     6781 tttttcatgg caattcaaga cgactgtatt agaaagaatc catttaattt ttagttaagt
     6841 gatgttttgg aagatacaac agaaccaaaa atcgctctaa caccagaaca ggaaatgggc
     6901 ttattatcct ttatggggag cgataagact tattataaat attatgatga tgttgttatc
     6961 ctcttagaaa caggactacg catttctgaa ttatgcggtt tgactttaga attagatatg
     7021 aaaaataaag ccattatggt agaccatcaa ttgttgagtg atactaagat tggctattat
     7081 gtagaagttc caaagaccac acagggtaag cgagaaattc caatgactga aagagcttat
     7141 caatcatttg aacgtatcgt tgaacggcgt aagaacgcta aagcagaacc aatcattgtt
     7201 gatggttacc agaacttcct atttcttaaa caagatggat taccaaaaca agcaactcat
     7261 tatcaaagca tgttaagagc gttagtcaag aagtataaca agacccatga ggacaagcta
     7321 ccaaagatta cgccacatac ctttaggcat acactctgta caaatatggc taacaaagga
     7381 atgagtacta atatattgca atatattatg gggcataaaa acattactat gacgcttggc
     7441 tattatgcac atggttcatt tagttctgcg agagctgaaa tggaacggtt ataatcctag
     7501 tagtatgact agagtttact acttatttac tacttttgat ggcattctta tacggttaaa
     7561 tgccaactta tgcaaagtat cttccaaaaa gaaaatgtcg atactccttg tagatacagg
     7621 atatatcgac atttaccaac ttatgaaaag ataatcaaat ttaatataag tttttcaaat
     7681 aaaaagatac taaattcttt ttagagaatc tatataacat tacttaagct tggttggggt
     7741 ataaacaatt gagtagctac ttttgtatgg tgttcaactt tagtcaaaac tcttaaataa
     7801 tgcaaatgat ttagattcat taatattcaa tctcttcata agtagtgaaa ttcgagttat
     7861 ttctgcataa ttatactatg atttatagat taattctatt agcatccaga ataatattgt
     7921 ttatatgagt aaaatttaaa gaatattgtg aaaattatag aatgttaaaa taaatttagg
     7981 taaaaaaaag tgtttgtata ttatagagta ccttttctaa aatatgtggg attgttttaa
     8041 gaattagaat aaaaattatt tttaaattag tatttttata atgtatagta tttttaatgt
     8101 ataattaaat tgtgcagaaa atagaattta aagtcctata gaatttctga ttatggagga
     8161 gaatatgaaa agaaaagttc aagtaaaaaa tattactatt ggagaaggta gacctaaaat
     8221 ttgtgtacca attattggga aaaataaaaa agatattata aaagaggcta aagagttaaa
     8281 agatgcatgt ttggatatta tagagtggcg agttgatttt tttgagaatg tagaaaatat
     8341 taaagaagtt aaggaagttc tctatgaatt aagaagttat atacatgata tccctttatt
     8401 attcacattt agaagtgtag tagaaggggg agaaaaatta atatcaagag attattatac
     8461 tactttgaat aaagaaattt ctaatacagg tttagtagat ttaatagatg tagagttatt
     8521 tatgggagat gaggtcatag atgaagtagt taattttgct cataaaaaag aagtgaaagt
     8581 aattatatct aatcatgatt ttaataaaac tccaaaaaaa gaagagattg tatctcgttt
     8641 atgtagaatg caggaattgg gcgcagattt acccaaaata gctgttatgc cgcaaaatga
     8701 aaaagatgtg ttagtgctac ttgaagctac aaatgaaatg tttaaaattt atgcagatag
     8761 accaataata acaatgtcaa tgtcaggaat gggtgttata agtagattgt gtggtgaaat
     8821 atttggttct gcattgactt ttggagctgc aaaaagtgtt tcagcaccag gacaaatatc
     8881 atttaaagag ttaaattcag tacttaatct attacataag agtattaatt aaattaatta
     8941 tatagaaata ttagaaggta ttttattttt gaagatataa attaaatata aaaaactttt
     9001 cagatagtaa aatttaaatt gggcaattat atctgaaaag caactattta gtgtgtattt
     9061 tgaaagtgat atagaaaatc ttataaatca actatggcat atttaaaata tgccattaaa
     9121 acctactaga cattagatta tagatggtat actagcattt ctattattta tagatagtaa
     9181 gttttcataa taactgtttt atctaaagta gaagatatat ttgtattatg tatatttgtc
     9241 attatttttt tgtaattatg tatattaatg gttatatatg taatataata ttatcactct
     9301 attttttgta tattgtacat tacaacattt atatctatca tcatcaatta cagtagaatg
     9361 tatgggatac ttattttcac ttaaccaata tttttgcata ttctttgtcc aagactttgg
     9421 aaacttcaat acttttttgt ttattataac atcctcatct tcaaaaatat taacttctct
     9481 ttctattttt atttttctgt tgtatatctt attgatagat tctttgtcga gttttatgtc
     9541 cctatacata tcagggcaat agcaacaaac ataatttctt ttttttcgac gtttaaattt
     9601 cacaactttc tctatgctaa tttctaattt ttttgtacca tcttttataa atttaatatc
     9661 ttctatgttc tcgcttgaaa aaatttctgt caatcttaaa gtatctacag tttctctaat
     9721 tatttgcttt ttataagaag agaatccata tccaaaagaa aggtttaatt tattagggat
     9781 gtagccattt ttatatttaa acatcttaat tttttccaat tcagcattat ctttaaattt
     9841 caacttttca tacctaaaag ttactttgct aaaaagagta tattctacat caatatattc
     9901 ttttgcaatc ttaaatttat cgctaccttc aatcacaatc atagcctatc tccaatcgtt
     9961 ttatattaaa ataaggccat agaacatggt ctaatagtac tcattagcac tataagacaa
    10021 tgttaacaca aaaagacaaa aaaaggttat ttatttcaaa taaccttttt ttttatataa
    10081 aatataaaga attatatttt attctttttt atgatgtcta taatctgtga tatcagattt
    10141 agttctcttg aatttaagtc ttttaactct tcatttatat cattttctaa atatgttttt
    10201 ccagtggaag taatatcttt tataagaaca tctgcagaaa tatttaatat atttacaaat
    10261 tttatgaatg ttttaagact tggattcttt ttaccacttt cgatttgagt tatataccaa
    10321 ggcgatactc caaccatatt tgcaaattct tttgaagtta aatttgcttt tttccgttct
    10381 tctttaagtc ttttacctat ataattcatt attgttacta tttccctcac ttatatttct
    10441 ttgtatttaa tgatgcactt tattaactct agcattgcaa tttgttcttt ttcagttaat
    10501 ttattaatca tttcataaca ttctaaaggt acagagttat caacgccttc tgttgtaata
    10561 atatttgcaa ataacaattc aagtggtatg tctaaagcag tagcaatttt cattataata
    10621 ttgatagatg tatttgtctc agctctttca atctgaccaa tatatgttgg atgtaaacct
    10681 gccttttctg ctagaaactc ttgactatat cccaattttg ttctatagac ttttattcta
    10741 tctcctatta tttttcctat atttgccaat tattatccct ccactttaga ttatattcat
    10801 agtttaagtt gttttatata gactatttat acttttttag tctaaatata gactatatat
    10861 gtttttatac tgaaataagt gctatttatt tttgtatagt ctgtatctac aataaacaaa
    10921 tatggataaa tcatattttt aattagagaa atattttcat aatttcatag ccatactaca
    10981 ataataaaac gaattaataa tatgttaatt atagcatttt ttattgtaat tacatattag
    11041 atatgtagaa tatattttga aaattaaaaa aattttctat tttatatatt gaacaattta
    11101 tgtaaataga aaatttttca ataagacttt tgagtttaat cattatattg gtaagg
//
LOCUS       DAEQCW010000114        11094 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.115, whole genome shotgun sequence.
ACCESSION   DAEQCW010000114 DAEQCW010000000
VERSION     DAEQCW010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11094)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11094)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11094
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.115"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            267..2279
                     /locus_tag="KRO40_003013"
     CDS             267..2279
                     /locus_tag="KRO40_003013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBH2093818.1"
                     /translation="MKKSVALVNDSRKDLIDFLENNLKLVFGDSININRYFINEINDN
                     DIINDDVILVMSVERLDKIINNILDKKKVIVVRRTFREDKIYNLLSLPQGTNVLIVND
                     SDETTLETISLFYKIGVTNIRPIPYMNDNNYKNIKIAITPGVPEKVPSFISDIFDLGH
                     RYIDISTFIEIINLLQIDSKEIQSNLVKYSEEIISLDTGIKDKYKELFLKIEELDTIL
                     NLSKDGILFTSKDGEINTYNSKVKDILDINEDIYGKYIEDIFVDSLKVLLSEKEILDK
                     VVVFNKKYINVNKKNIYNRDEKMGTYYSLQEITYIKKLEQNLTKKLREKGQIAKYTFK
                     DIKTNSPKMFECIDLAKKVSKSDLSILIRGESGTGKELIAQSIHNNSNRKNQPFIAVN
                     CAAVPENLLESQLFGYDKGTFTGGLKDGKQGLFELANNGTIFLDEIGDMPLELQTKLL
                     RVLQEKQIMPVGSHNVINIDVRIISATNKNLEQMIDNSQFREDLYYRLNTIPINIPPL
                     RERKEDILIIMEDLINKKLVITPEAKKLIQNYMWKGNIRELQNVTSYLNIMCEDIVLE
                     KDLPPNLRSSDNKNTSLKLKYSKNDILNILEILILNKESDVGIGRGLILKALLDKNLQ
                     ITEGKIKKIFEYLKKEELIICSSGRYGSKITQKGEDFYNKLKYKGL"
     gene            2648..3868
                     /locus_tag="KRO40_003014"
     CDS             2648..3868
                     /locus_tag="KRO40_003014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093819.1"
                     /translation="MQQALKLKYQTKELGKDFVIESCNSIKPWLINIRRELHKIPELA
                     LEENLTKQKVISYLKEIGIDYMEFTKHNGIMAYILKESADKTICIRADMDALPIEEEN
                     NIPYKSIHSGKMHACGHDAHTTMLLGACKVLHSIKDKLNVNVKFLFQPAEEGFGGAKF
                     LVEDGCLENPKVDYIFGLHVMPHIETGFIETKYDTLNASVDTIKISIKGKRAHGAYPE
                     NGIDAIVTASQIVTSLQTIISRNLEPNNAAVLTIGKIYGGDAHNVICEDVKLEGTLRT
                     LNSKTRNFMIDKIAKIVGDTASAFGCVGTLHVSDENYPAVINEKELVDTVISNTKELL
                     GEEKFILRPNPSLGGEDFSFYTEHCKGAFFHLGCKNEEKGLISPLHTSSFNIDEDCLP
                     IGVMMHVMNTLYFN"
     gene            3905..5254
                     /locus_tag="KRO40_003015"
     CDS             3905..5254
                     /locus_tag="KRO40_003015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBH2093820.1"
                     /translation="MEKAKKLGLFSMILLGINSIIGSGIFLLPGKVYNLAGQNSMFIY
                     IFATLLVLSILLCFAEVGSMFDKNGGAYLYSKKAFGDFIGFEVGTMSWVIRIISWSTL
                     AVGFATALGSFWPESATEYKGYIAAILVTLLSINSLFGIKSTKIMNNVITIAKLVPLI
                     VFIIVGIFFIKFVNIVPSGNVVNSSMGPAIILVFYAFTGFESFIVASGEMENPKKNLP
                     VALITTIFICAIIYILIQIVCMGILGDRLFENSIPIADASSVFLGNYGKVFISVATLI
                     SIFGINIGSSIVTPKCGSSLAEEGSLPAFIGKTNKYGAPYVAIIISLICCIPLVLTGS
                     FEQLAVMSVIARFAQYIPTCLSVIVLRKRTDVKASFKIPFGPVIPMVAILGSLWLLQQ
                     AWAEDISKPITQNRVLIGLGAMLLIAPLYIFMKKNKEIEHKNKSEDSKLYISREKIQ"
     gene            5368..5930
                     /locus_tag="KRO40_003016"
                     /pseudo
     CDS             5368..5930
                     /locus_tag="KRO40_003016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901678.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(6038..8371)
                     /locus_tag="KRO40_003017"
     CDS             complement(6038..8371)
                     /locus_tag="KRO40_003017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2093821.1"
                     /translation="MRSYLELVPQYAKVHKKKNRTTILCIVIAVCLVTAIFGLADMAI
                     QCQKVQFIKDDGNWHIVLKNLNEEAISEISSRVDIAHYGRGQVIDNGEFKSKEILIQG
                     LDEDLAKQLGLEIIKGRYPVVENETLIDVDAVKSFNLKVGDFIKIKLADGRNKNYKIV
                     GEYSSLSSLRASDKHGLMLSILGTQAIKKSETYDYYYITFKDKVNIRKATSDIKNTFN
                     LSDKQIGKNEKLLSIIGQGDSDYSKPLYLTAGGLFILVLIASIIMIYNSFNMGVIERI
                     KFFGLLRCLGASKLQVKKFVVLESLILSVKAIPLGLLLGCIVTIISSIFLKYVNTELF
                     GSMPILKVSFIGIVFGIIVGFLTVILSAIVPAKKASGVSPLSAIRGNLMFKEILTSGK
                     ASKIANAGSSKIDVSMGINHAFSRKKSFILMTSSFAISIVLFLGFSVFIDFMYQALKP
                     IKPEAAHISIVDADFKSVLTKDDINEISNIKGIKKVYSRMMTDVEATYNNKEATSQLI
                     SYEKNQFDWAKKYLVKGEINEDKLESENIGLVEEGHGFNIGDKIYIKNGNSKKEIEVA
                     GILSSISFDVKDKYIGNIITSENTFTSITDIKDYIIIDTQVDEDAPEDLIQNIRNVLD
                     DNLEVRDKRQGNLEAKNSFYTMAVFVYGFVFIIAIISMFNIINSMNISVTSRINYYGI
                     MRAIGMSNKQLRKMVIVESSTYAVSGCLLGSVLGLILHRYIFVSLVTLKFHIDWQIPF
                     DLLFIIVVTMIIITLLAVRKPIKKICELDIIEVVNAQ"
     gene            complement(8368..9051)
                     /locus_tag="KRO40_003018"
     CDS             complement(8368..9051)
                     /locus_tag="KRO40_003018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093822.1"
                     /translation="MDILVVNNLCKTYGNGYTKVEALKDVSFTVSKGEFVTVVGESGS
                     GKSTLLNLLGGLDTPTSGKIFVDGKEICSMKEEKQTIFRRRNIGFIFQSYNLIPELTV
                     EQNIIFPLLLDYKKPDTIYLDEVLTILGLKDRKSHLPNQLSGGQQQRVAIGRALITKP
                     SIILADEPTGNLDSKNSSDVISLLKVTAEKYNQTIIMITHNTNIASTADRILQVSDGM
                     LKDLGVNRE"
     gene            complement(9122..10363)
                     /locus_tag="KRO40_003019"
     CDS             complement(9122..10363)
                     /locus_tag="KRO40_003019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2093823.1"
                     /translation="MKVFSNKDIKIFFLVIISVLLMFIVVGQIVVINITNDYKSALLE
                     HDYNIAGYLNSMGVDKSKIPAVFTTNEDKYTLKGKEILNTARYDFGTDDSFMPSVKLF
                     QGKYIKTMFLYLFVFFTMIIFILYVYFFKQQNKIEEASYKIDSFMNGNINVRLNTYEE
                     GSLSKLFGSIDAMSTSLNTHILKEKQNKEFLKNTISDISHQLKTPLTALMMYNQILQE
                     ESHNSEIVENFVQKSQNELERIESLIQNLLKITKIDSKTIILNKASVNVKKLITKILY
                     SFETRAEKEGKSISIRGLENTNLFCDYEWISEALSNLIKNALDNTKENDKIMIEWVET
                     PITTIISVSDTGNGIHIEDIHHIFKRFYRSKFSKSNQGLGLGLPLVKSIIEQHNGTIT
                     VESNFLQGSTFTLSFLKLTNM"
     gene            complement(10374..11060)
                     /locus_tag="KRO40_003020"
     CDS             complement(10374..11060)
                     /locus_tag="KRO40_003020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093824.1"
                     /translation="MSSILLVEDDLSLIYGLEYSIQKNGFSVDVARTVEEALQIYKEK
                     NYDLLLLDVSLPDGDGFDICKRVREASNVPIIFLTASDEEVNVVMGLDMGGDDYITKP
                     FKLNELISRIKALLRRYNFTSENVTELKSNNITVKLLENRVFKNEIELELTTAEYKLL
                     CLLMKNKNIVLTRKNILDKLWDGNGSFVDDNTLSVYVRRLRNKIEDNPENPKILLTVR
                     RMGYKWNVIK"
BASE COUNT         4101 a         1560 c         1456 g         3977 t
ORIGIN      
        1 gaatttatta aaataaattt ttttgggtgt atattataat ttaatcgaat agaaatgaaa
       61 aatatacata cagtttaagt tttaagcaac aattaggggg atttggtgac aagattttta
      121 attataagaa agaaagtgtc ttaatgcaac ttttataaag tcattataga cactttcttt
      181 tttatttgat aaatttaaat tatcaaaatt atattgcttt atacaactat tttgttggaa
      241 actatttatt atataaggag aaataaatga aaaaatcagt agctctggta aatgatagta
      301 gaaaagattt aatagacttt ttagaaaata atttgaaatt agtttttgga gattctataa
      361 atattaatag atacttcata aatgaaataa atgataatga tattataaat gatgatgtga
      421 tattagtaat gtcagtagaa agattagaca aaattataaa taatatacta gataagaaaa
      481 aagtgattgt ggtaagaaga acttttaggg aagataaaat ttataatcta ctatctttac
      541 cacagggtac aaatgttcta atcgtaaatg attctgatga aactactcta gaaactataa
      601 gtttatttta taaaattgga gtgactaata ttagaccaat tccatatatg aatgataata
      661 actataaaaa tataaaaata gctataactc caggagttcc agaaaaagta cctagcttta
      721 tctcagatat atttgattta ggtcacagat atatagatat ttctacattt atagaaataa
      781 taaatttatt acaaattgat tcaaaggaaa tacaatctaa tctagttaaa tactcagaag
      841 aaataataag tttagatact ggtataaaag ataaatataa ggaattattt ttaaaaatag
      901 aagaattaga tacaatattg aatttatcaa aagatggtat attatttact tcaaaagatg
      961 gtgaaataaa tacatataat agtaaagtaa aagatatttt agacataaat gaggatatat
     1021 atggaaaata cattgaggat atatttgtag atagtttaaa agttttattg agtgagaaag
     1081 agatactaga taaagttgtc gtattcaata agaaatatat aaatgtaaat aaaaaaaaca
     1141 tatacaatag agatgaaaaa atgggcacat attatagttt acaagaaata acatacataa
     1201 aaaaattaga acaaaatctc actaaaaaat taagagaaaa aggacaaata gcaaaatata
     1261 catttaagga tataaaaaca aatagtccta aaatgtttga atgtatagat ttagctaaga
     1321 aagtttctaa atctgattta agcatactta tcagaggtga aagtggaact ggtaaagaac
     1381 tcatagctca gtctatacat aacaactcaa atagaaaaaa tcaacccttt atagcagtaa
     1441 attgtgcagc cgttcctgaa aatttattag aaagccagct attcggatat gacaagggaa
     1501 cttttactgg aggtctaaaa gatggaaaac aaggattatt tgaacttgct aataatggaa
     1561 caatattctt agatgaaata ggcgatatgc ctttagaatt acaaacaaaa ctacttagag
     1621 ttcttcaaga gaaacagata atgcctgttg gttctcacaa tgtgattaat atagatgtta
     1681 gaatcatatc tgctacaaat aagaatttag aacaaatgat tgataatagc caatttagag
     1741 aggatttata ttatcgatta aatacaattc caataaatat acctcctcta agagaaagaa
     1801 aagaagacat attaattatt atggaagatt taattaataa gaaattagta atcacaccag
     1861 aagcaaaaaa acttatacaa aactatatgt ggaaaggtaa tataagagaa ctccaaaatg
     1921 ttacatccta tttaaacatt atgtgtgaag atattgtatt agagaaagat ttacctccaa
     1981 acttaaggtc ttcagataac aaaaatacat cattaaaact aaaatatagt aagaatgata
     2041 tattgaatat attagagata ctaattttaa ataaggaatc agatgttggt attggtagag
     2101 gattaatttt aaaagcacta ctcgataaga accttcaaat tacagaagga aaaattaaaa
     2161 aaatatttga atatctaaaa aaagaagaac ttataatttg tagttcagga agatatggaa
     2221 gtaaaataac tcaaaaagga gaagattttt acaataaatt aaaatataaa ggtctataaa
     2281 attataattt atcaaacaaa gaaatctatt caggattaaa gtactccttc aataggtttt
     2341 tttatttttc aagtacccta aaattataat ttattttgta cataaataat aggaattaat
     2401 aggaatagga taattttttt atttcctatt ttttttatat aaactagcat ataaaatata
     2461 ttttcttcaa aataatattt tttactgaaa attgaaacta tgcaatcatt ttttatacta
     2521 tacatataga taaatgatta tatttattca atattcttat aaaaaacaaa gttctccatc
     2581 gaaaattatg gcataataat tgcttattat attaataaaa caataaaaag caattggagg
     2641 aataaaaatg caacaggctt tgaaattaaa atatcaaacc aaagaattag gaaaagattt
     2701 tgtaatagaa agttgtaatt ctataaaacc atggcttata aacataagaa gagaattaca
     2761 taaaattcca gaattagctc ttgaagaaaa tcttactaaa cagaaggtaa tttcttattt
     2821 aaaagaaatc ggaattgatt atatggaatt tacaaaacac aatggaatta tggcatatat
     2881 tttaaaagaa agtgcagata aaacgatttg tataagagca gatatggatg ctcttcctat
     2941 tgaagaagaa aacaacatac cttataaatc aatacattct ggaaaaatgc atgcttgtgg
     3001 ccatgatgca catacaacca tgctacttgg agcatgtaaa gttttacatt caataaaaga
     3061 taaacttaat gtaaatgtaa aattcttatt tcaaccagca gaagaaggtt ttggaggagc
     3121 aaaattctta gttgaagatg gatgtttaga aaatcctaag gtcgattata tattcggact
     3181 tcatgttatg ccacatatcg aaacaggatt tatcgaaaca aaatatgata cattaaatgc
     3241 tagtgtagac actataaaaa taagtatcaa aggtaaaaga gctcatggtg catatcctga
     3301 aaatggtatt gatgcaatag ttacagcttc acaaattgtt acatcattac aaactataat
     3361 aagtagaaac ttagaaccaa ataatgctgc tgttttgact ataggtaaaa tatatggtgg
     3421 tgatgcacac aatgtaatat gtgaagatgt aaaactagaa ggcactttaa gaaccttaaa
     3481 tagcaaaaca agaaacttta tgattgataa aatagctaaa attgttggag acactgcatc
     3541 tgcatttggt tgtgttggga ctttacatgt aagtgatgaa aactatcctg ctgttataaa
     3601 tgaaaaagaa ttagtagata cagttatatc aaatactaaa gaattacttg gagaggaaaa
     3661 atttatattg agaccaaacc cgtctttagg tggtgaagac ttttcttttt acacagaaca
     3721 ttgtaaagga gcattcttcc atttaggatg taaaaatgag gaaaagggct taatttcacc
     3781 tcttcatacc tctagcttta atatagatga agattgttta ccaataggtg ttatgatgca
     3841 tgtaatgaat actttgtatt ttaattagta cagtaattaa taaaagaata ggagataaat
     3901 taatatggaa aaagctaaga aattaggtct atttagtatg atattattag ggattaatag
     3961 cataataggt tcaggtatat tcttactacc aggtaaagtt tataatctag caggtcaaaa
     4021 cagtatgttt atatacattt ttgctacact cttagttcta tcaatacttt tatgttttgc
     4081 agaagttgga agcatgtttg ataagaatgg aggagcatat ctatactcca aaaaagcttt
     4141 tggagatttt ataggatttg aagttggtac aatgtcttgg gttattagaa ttatatcatg
     4201 gtctactcta gcagtaggat ttgcaacagc tttaggttca ttttggccag aatctgccac
     4261 tgaatacaaa ggttatatag ctgcaatact cgtaacacta ctttcaataa atagcttatt
     4321 tggaattaaa agcacaaaga taatgaataa tgtaataact atagctaaat tagtaccatt
     4381 aatagttttt ataatagttg gaatattctt tataaaattt gtaaatattg ttccttcagg
     4441 aaatgtagtt aactctagta tgggtccagc cattatatta gtattttacg catttaccgg
     4501 ctttgaatca tttattgtgg caagtggaga aatggaaaat cctaaaaaaa atcttccagt
     4561 cgcattaata accacaatat ttatatgtgc aataatttat atattaattc aaattgtctg
     4621 tatgggtata cttggagata gactatttga aaacagtatt ccaattgcag atgcttcaag
     4681 tgtattttta ggcaattatg gtaaagtttt catatctgta gcaacattaa tatctatatt
     4741 tggtataaat ataggttcat caatagtaac tcctaaatgt ggttcttctc tagcagaaga
     4801 aggttctctt cctgcattta taggaaaaac aaataaatat ggtgctccat atgtagcaat
     4861 aataatatct ttaatttgtt gtataccact tgtgctaact ggaagttttg aacaacttgc
     4921 agtaatgagt gtaattgcaa gatttgctca gtacatacca acttgtttat cagtaatagt
     4981 tttaagaaaa agaacagatg ttaaggcctc ttttaagatt ccatttggtc ctgttatacc
     5041 aatggtagct attttaggta gcttatggtt gttacaacaa gcttgggcag aagatatttc
     5101 aaaacctata actcaaaata gagttttaat aggattaggg gcaatgttgt taatagctcc
     5161 tctatatata tttatgaaaa aaaataagga aatcgagcat aaaaataaat cagaagattc
     5221 taaattatat atttcgagag aaaaaattca ataatatttt acaaactatt taaaaattat
     5281 ttttctaata ctatagaaat aattagaaat ggagatgtta cgtatctaaa agtagttgat
     5341 aacacggata ttggtacttt tatagatatg ggacttacaa aagacatact agttcctttt
     5401 aaagctaaga cttatccatt gtttagagat gaaaaatatt tattctatat atacttggat
     5461 aaaagcggaa gaatagctgc tactacagac atagattcat atttagaaac agaccatact
     5521 tacaatgtag gagatgttgt aaatggagtt gtatatggat tccaaaccaa caactctgct
     5581 atgatatgtg ttgacaataa atatgctggt gtaatccttc ataatgaata ctttacagaa
     5641 ttaaaagctg gggatgttct tgaaaattta catgttataa aaatatacga tgatggtaaa
     5701 ttaggacttt ctcctagagg aaacagaaaa gatgaacttg ataccttaga aaataagatt
     5761 ttaagctatt tagaaggttc agatggatat atgagattca atgataaatc tgatcctaaa
     5821 gatatttcta tcttatttaa ttcaagtaag aaaattttaa acgtgctctt ggagtactta
     5881 tgaagaaaga cttaatttat caagatgaag atggaactta tctaaagtaa attatataac
     5941 acaaaaatcg aagtaaatta tgaaagatat tttctatttc atatttactt cgatttttta
     6001 tttaaattac tacctctatt taaattacta cttatattta ttgtgcattt actacctcta
     6061 ttatgtctaa ttcacaaatc tttttaatgg gttttcttac tgcaagcaaa gttattatta
     6121 tcatagttac tacaatgata aacagtaaat caaaaggtat ttgccagtct atatggaatt
     6181 ttaatgttac taaggataca aatatatatc tatgtaatat taatccaagt acactcccca
     6241 ataaacagcc acttacagca tatgtacttg attctactat taccattttt cttaattgct
     6301 tattggacat gcctattgca cgcataatac catagtaatt tattctactt gtaacgctta
     6361 tattcatact gtttatgata ttaaacatac ttataatcgc aattataaat acaaacccat
     6421 atacaaaaac tgccatagtg taaaatgaat ttttagcctc taagttacct tgtcgcttat
     6481 ctcgaacctc taaattatca tctagaacat ttcttatatt ttggattaaa tcttcaggag
     6541 catcttcatc aacttgagta tcaattatta tatagtcttt tatatctgtt atactagtaa
     6601 aagtattttc agatgttata atatttccaa tatatttgtc tttaacatca aatgaaattg
     6661 aagaaagtat acctgctacc tctatctctt tcttagaatt tccattttta atatatatct
     6721 tatctccaat attaaaccca tgaccttctt ctaccaatcc gatattttct gactctaatt
     6781 tatcttcatt gatttcccct tttactagat actttttggc ccagtcaaat tgattttttt
     6841 cataagaaat tagctgagat gttgcctcct tattattgta tgtagcctct acatccgtca
     6901 tcattctact gtatactttt tttattcctt tgatattact tatttcatta atatcgtctt
     6961 tagtaagaac agacttaaag tcagcgtcaa caatagatat atgagcagct tctggtttta
     7021 taggtttaag tgcctgatac ataaagtcta taaatacact aaaacctaaa aacaatacaa
     7081 tactaatagc aaatgaagaa gtcataagta taaaagattt ttttcttgaa aaggcatgat
     7141 ttattcccat agaaacatca attttagaac ttcctgcgtt agcaatttta cttgcttttc
     7201 cactagttaa aatttctttg aacattagat taccacgtat agcacttagt ggagacaccc
     7261 cagaagcttt ttttgctgga acaatagctg ataatattac tgttaaaaat cctactatta
     7321 ttccaaacac aataccaata aagctaacct ttaaaattgg catcgaacca aataactctg
     7381 tattcacata tttgagaaat atagaggata taatggttac aatacatcct aataacaatc
     7441 ctagtggaat agcctttaca cttagaatta aactttctaa aacaacaaat tttttgactt
     7501 ggagttttga tgctcccaag caacgtaata gtccaaaaaa ctttattctc tctattacac
     7561 ccatattaaa gctattatat atcatgataa tacttgctat taacacaagt ataaaaagtc
     7621 ctcctgctgt taagtaaagt ggtttagaat aatcagagtc accttgacct ataatagaaa
     7681 gtaatttttc atttttaccg atttgtttat cacttaaatt gaaggtattc ttaatatcag
     7741 aagtagcttt tctaatatta accttgtctt taaatgtaat ataataataa tcatatgttt
     7801 ctgatttttt gatagcttgt gtacctaata ttgaaagcat taatccatgc ttatctgagg
     7861 ctcttaagct tgataatgat gaatattcac ctactatctt ataattttta tttctaccat
     7921 ctgctaattt tattttgata aaatctccta cttttagatt aaagctttta actgcatcta
     7981 catctattaa agtctcattc tccacaacag gataacgacc ttttattatt tctagaccta
     8041 attgttttgc taaatcttca tctaaacctt gtatcaaaat ctcctttgat ttaaactctc
     8101 cattatcaat gacttgtcct ctaccatagt gagctatatc tactctacta cttatttctg
     8161 atatagcttc ttcattaaga tttttaagta ctatgtgcca atttccatca tcttttataa
     8221 attgtacttt ttgacattgt atagccatgt ctgctagtcc aaaaatagca gtaactaaac
     8281 atactgcaat gacaatacat aaaattgtag ttctattttt tttcttatgt acctttgcat
     8341 attgtggtac tagttctaaa tagcttctca ttctctattc acccctaggt ctttaagcat
     8401 tccatcagaa acctgtagta tcctatctgc tgtagaagct atatttgtat tatgagttat
     8461 cataataata gtttggttat atttttctgc tgtcactttt aaaagtgaaa ttacatcact
     8521 gctattttta ctgtcaagat ttcctgttgg ctcatctgcc aatataattg atggctttgt
     8581 aatcaatgct cttccaattg caaccctttg ttgctgacca ccagataatt gatttggaag
     8641 atgacttttt ctatctttaa gacctaaaat tgtcaatact tcatctagat aaatagtgtc
     8701 tggttttttg taatctagta gtaaaggaaa tattatattt tgttccacag ttaattcggg
     8761 tataagatta tatgattgaa agataaaacc tatattacga cgtcgaaaaa tagtctgttt
     8821 ttcttctttc attgaacata tttctttacc atcaacaaat atttttcctg aggttggagt
     8881 atcaagacct cctaaaagat ttaataatgt actcttacct gagccagatt ctccaactac
     8941 agtaacaaac tctccctttg aaactgtaaa tgatacatct tttaatgcct ctacttttgt
     9001 atatccattt ccatatgttt tacataaatt attaaccaca agaatatcca tttgctctat
     9061 ctcctttctg atgattaata taagaataat tcatacacct tactgtaaga tgtatcctat
     9121 cttacatatt agtaagcttt aaaaaactta gagtaaatgt acttccttgt aaaaaattac
     9181 tttctacagt tatggttcca ttgtgctgtt ctatgataga tttaactagt ggcaacccta
     9241 atccaaggcc ttgattactt tttgaaaact tactcctata aaatctttta aatatatgat
     9301 gtatatcttc aatatgaatt ccatttccgg tatcactcac tgaaataata gttgttatag
     9361 gtgtttcaac ccattctatc attattttat cgttctcttt tgtattatct aatgcatttt
     9421 ttataaggtt gcttaaagct tctgatatcc attcataatc gcaaaacaag tttgtatttt
     9481 ctagacctct tatagagata ctctttcctt ctttttctgc tctagtttca aaactatata
     9541 aaattttagt aatcaacttt tttacgttaa cactagcttt gttaagaatt attgtctttg
     9601 aatctatctt tgtaatcttt aacaagtttt gtatcaatga ttctatacgc tctaattcat
     9661 tttgactctt ctgcacaaaa ttctcaacaa tttcactatt atgactctct tcctgcaata
     9721 tttgattata catcatcaat gctgtaagtg gagtttttag ttgatgtgat atatctgaaa
     9781 ttgtattttt aagaaattct ttattctgct tttctttcaa tatatgtgtg tttagagatg
     9841 ttgacatagc atctattgaa ccaaataact ttgataaact accttcttca taagtattta
     9901 accgtacatt tatatttcca ttcataaatg aatcaatttt ataactagct tcttctatct
     9961 tgttctgttg cttaaaaaaa tacacataca atataaaaat aatcatagta aagaacacaa
    10021 ataaatacaa aaacatagtt tttatatatt taccttgaaa caatttcaca cttggcataa
    10081 aactatcatc tgtaccaaag tcatatctag ctgtatttaa gatttctttt ccttttaaag
    10141 tatatttatc ttcattagta gtaaatactg ctggtatttt tgatttatca acacccatac
    10201 tatttaagta tccagctata ttataatcat gttctaacag tgcactttta taatcattag
    10261 ttatatttat aactactatt tgacctacta ctataaacat caataaaacg gatataatca
    10321 ccaaaaaaaa tatttttatg tctttattag aaaatacctt catattaaca ccctcacttt
    10381 ataacattcc atttgtaacc cattcttcta actgttaata gaatttttgg attttcagga
    10441 ttatcttcaa tcttatttct taaccttctt acatatactg acagagtatt atcatctaca
    10501 aaactaccat ttccatccca taacttatcc aatatatttt ttcttgtaag tacaatattt
    10561 ttatttttca taagtaagca taataattta tattctgctg tagtaagctc aagctcaatt
    10621 tcatttttaa aaacacgatt ttcaagtaat ttaacagtaa tattatttga ttttagttca
    10681 gttacatttt cacttgtaaa attataacgt ctaagtaaag cttttattct tgaaattaac
    10741 tcatttaatt taaaaggttt tgttatgtaa tcatctccac ccatatcaag tcccatcact
    10801 acatttactt cttcatcaga agcagttaaa aatatgattg gtacattaga agcttctctt
    10861 acccttttac aaatatcaaa accatcacca tcaggtaagg atacatccaa aagcagtaaa
    10921 tcataatttt tttctttata aatttgcaat gcttcttcta ctgttcttgc tacatcaaca
    10981 ctaaatccat tcttttgtat agaatattct aatccatata tcaaacttaa atcatcttca
    11041 accaacaata tactactcat ctcaatcact tccatttttt tattttttac ttta
//
LOCUS       DAEQCW010000115        10934 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.116, whole genome shotgun sequence.
ACCESSION   DAEQCW010000115 DAEQCW010000000
VERSION     DAEQCW010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10934)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10934)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10934
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.116"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(795..1529)
                     /locus_tag="KRO40_003021"
     CDS             complement(795..1529)
                     /locus_tag="KRO40_003021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2093825.1"
                     /translation="MNLAKGLDVLKISSNVFGEDKVMYIPVIYTEDDATLIDTGLPGQ
                     GDLIIDALNKSNTSFDRLKNIIITHHDIDHIGNINYLREKSKNNIKVYAYKSEISYIT
                     GEETPFKLYMLEQMVDKIDDKMLSMLNVMGLGFKSSYTKVDVSLDNHEKLNLGEEIEV
                     IHTGGHTRGHICLYLKESKVLIAGDLLQVENGELKPVDVMYSNKQELKDAIKNISNYD
                     IETIVFSHGGLYQRNIIGTLKNLIIE"
     gene            complement(2535..3173)
                     /locus_tag="KRO40_003022"
     CDS             complement(2535..3173)
                     /locus_tag="KRO40_003022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH2093826.1"
                     /translation="MLIHLVKKDILIVKKYVLLILFIAIGIPLFILWRLPPFAQILGF
                     VLSIIFSEFMLCQYLLLKESQYSKASVLLCSTPYPRRGLVQSKYVLFAMVFIYCTLVY
                     WIENLLIPQIGTFDLTYILIVLLISSIIYGVYMPIQYKLGYETTKFFFVVIIMASSFV
                     LPLTIAHSNFEIPFIYQYPSMIVNIVLFLLSLIILLASMFISIKIFSNKELV"
     gene            complement(3176..4033)
                     /locus_tag="KRO40_003023"
     CDS             complement(3176..4033)
                     /locus_tag="KRO40_003023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093827.1"
                     /translation="MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTT
                     TIRSILDVVKRDSGKIKIFGKDFDGNEKELKNRIGVVFDDSYFYEELSMAEMKSIIAP
                     SYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
                     DPLIRSQILDILTEYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLL
                     DEHRKVKGDIQFLNDETKKLFLNLEITGYGFIGITSKINEVQKNMPDILIERPTIEDI
                     MLAYIERRE"
     gene            complement(4035..4409)
                     /locus_tag="KRO40_003024"
     CDS             complement(4035..4409)
                     /locus_tag="KRO40_003024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2093828.1"
                     /translation="MKVLISNTSDKPLYQQIKEQIKEAIFTEELKEGDAMPSIRNFAN
                     DLKVSILTIRRVYEELENEGFLTRQVGIGTFISTGNLEILRDSKRRIVEQKMADMIKD
                     AKALGITQIELQEMMDILYQED"
     gene            complement(5558..6748)
                     /locus_tag="KRO40_003025"
     CDS             complement(5558..6748)
                     /locus_tag="KRO40_003025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBH2093829.1"
                     /translation="MSDMLLWFSVVLVLFAIGDLIASKTKAKVSAVFVTLLLFLILFV
                     TKAIPADIIEKAGMTAAASWSVPMIMFSMGTMLNVKQFIDEWRTVLTAWLGIVAVIVC
                     VSLCIPLFGKSTVLTSIPVINGALPATTIMTQAALEKGLTLAAATATVVFAIQKFIGT
                     PIASRAALQEANRLLVEYHEAKSKGIDLANVDTDKKEAENTGTKVKQAFCEKYDKYYS
                     TNVCIFFIALFSYLGYELSEIIHVNYSIVCLVVGVIVTRIGIVPKDILEKGKIKGFIN
                     MVVFAAVIPSLAKVSLTDLISLFVPIVGMFAASIIGIFLMMKVLPGWKIIGSKPLAFG
                     VGFCQMLGFPTTYLISNEVCNAVGETEEERAYLMSKIMPKLVVGGMACMISIVVAGLM
                     VPML"
     gene            complement(6764..8719)
                     /locus_tag="KRO40_003026"
     CDS             complement(6764..8719)
                     /locus_tag="KRO40_003026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBH2093830.1"
                     /translation="MEKIKIESSDIFEYIFPHDISCSPDGKHIAYIISNINEEKDCYE
                     HDLYVMDIKTEKQIHMTQTKDVTSFSWISNTELLFTSKRNKPKSGTTDFYTISIEGGE
                     AKKAFSIPKACSVPVSLGNKLWLLTTKNPTDSKKSEPDRAVEGVDYWTFTDKPFIRDG
                     ENFSQRRRVTLELYQEGENITKAITPKFCEVAGVDVSSDKNRILYTGQIYEDCATPFS
                     GLWEYHIDSGETKELVPQGKYQISLAKYIGKDKVMLQASTLDRSITQNHDIFILDLST
                     NEINMIASPDGMYATLLDVDAVYGGGRSNKVIGDKFIGARICRTMTEFNEFDTKTGNI
                     RIITKVDAFTSFDIYDNTMYTVMLKDYELAEIYSIDMTTGTMKKMTAFSKPYLDTHKV
                     SLPEKLTFVAKNKEEVDGFVIPPIDAKEGEKYPAVLFIHGGPKWAYGYMFTHLKQCVT
                     SKGMYVIYCNPHGGDGYGEKFLEMVERWGYVDYEHLMEFVDTCIEKYPGIDADRLGVA
                     GGSYGGYMTNWIIGHTDRFKAAASQRGISNLITASLIIDFGDRIMKQTCGDKTPWNHE
                     EVLWNHSPIKYVKNVKTPTLFLHSDRDYRCFMGDTFQMFTALKQLGVDTEMYLFHGDT
                     HGLSRNGRPSNRIARANAIVDWFERYL"
     gene            complement(8736..10802)
                     /locus_tag="KRO40_003027"
     CDS             complement(8736..10802)
                     /locus_tag="KRO40_003027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBH2093831.1"
                     /translation="MKEVVGSLKKITKERTENTMKKLFTSETFLEYQFISDCQISPDG
                     GYTAFIVKKADIKENGYTSQVYILNNKTGELKQITSINSVGAYAWEDENTILFPALRN
                     EKVKEAVKNGKQCMSYYALSLNGGEAEELFRLPIKGGKLNPIGKGLYAVIDSYDNDRP
                     IVEGLPEEEQQKKINAYNKRHYEHFKEIPYAVNGEGYISRKRKRLYIYDSNINELKAI
                     TAPMFNVVGMKISDGKILYIGQEFKDVKGLKNGVYVFDTNTNTNVCILEKDKYIIKGF
                     ELYQNQVILNLTDALSYGNGENGDFYTIDIDTKEMKLLSGHQHHCIGNTVTSDVKMGA
                     GQTTKVDGEYIYYTSTVDMDCIIERIHIPTGKQEKVTQTGSVDFIDVKDGNIVCVGCL
                     GNGLPEVYTVENGTLCKKTHLNDHILEEYKISVPEYIESKGSSKWEIQGYVYKPVDYE
                     VGKKYPAVLAIHGGPRLTYGPYFMHEIQVFTSAGYFVFFCNPRGSEGRGNAFADIRKQ
                     FGDIDYIDFMEFTDTVLEKYTDIDKTKLAVEGGSYGGFMTNWIIGHTNRFAVACAQRS
                     IANWSGMEGTTDIGYYFCKGQTGASHMENHELQWKQSPLAYADKCVTPTLFLHGEKDY
                     RCYMQEAFQMFSALKIHGCPTKLCLFEGENHELSRSGRPKQKLQRLVEMLDWFSVYIK
                     KDNIGQ"
BASE COUNT         3696 a         1901 c         1251 g         4086 t
ORIGIN      
        1 ctgcttatat tataatacat aatttaaaca tttttcttca ctttgcatta tgatacatga
       61 tttaaatttt ttctttactc tacattatga tatattattt aaatattttt cttcactctg
      121 cttatattat gatacataat ttaaacattt ttcttcactt tgcattatga tatatggttt
      181 aaataatctt ctttactttg tattatgata catgatttaa atatttttac tcactttata
      241 ttataataca tgctttaaat aatcttattc gctttgtatt ataacacatg ctttaaataa
      301 tcttattcgc tttgtattat aacacattat ttaaatattt ttactcactc tacattatgg
      361 tacattattt aaatattttt cttcgctttg cattatgata catgatttaa atatttttac
      421 tcactttgta ttatggtaca ttatctaaat atttttcttc actctgcatt atgatatata
      481 acttaaatat tttacctcac tctacaatat tatatataat ttaaatattt ttcttcactt
      541 tgtatgctaa agtttattta aagtattttc tttcctatta tactatgctg ttaaatattt
      601 ttcaactgaa gtattgtaga accttaaaat tactataaaa aattatattc taaaatactt
      661 gtaatactac gtatcatcct taacacttaa gtataatttt aaagcaaaat tcttattact
      721 tatatttaat tttgattcta catctttaga tataatttta agtaatttaa gaaattattg
      781 taaatcatat agtactactc aataattagg tttttcaatg ttccaattat gtttctttga
      841 tataatccac catgactaaa aactatcgtt tctatatcat aattacttat atttttaata
      901 gcatctttta actcttgttt gttgctgtac atcacatcaa caggcttaag ttctccattt
      961 tctacctgta acaaatctcc agcaataagt actttagact cttttaaata aagacatatg
     1021 tgacctctag tgtgacctcc tgtatgtata acttctattt cctcacctag attcaatttt
     1081 tcatggttat ctaatgacac atctacttta gtatatgatg atttaaatcc aagtcccata
     1141 acatttagca tactaagcat cttatcatca attttatcta ccatttgttc caacatataa
     1201 agtttaaaag gagtttcttc tcctgttata tagctgattt cacttttgta tgcatatact
     1261 ttgatattat tcttagattt ttctcttaga taatttatgt ttcctatatg gtctatatca
     1321 tgatgagtaa ttattatatt ttttaaccta tcaaagctcg tgttactttt attaagagca
     1381 tcaattatta aatcaccttg acccggaaga cctgtgtcaa taagtgttgc atcatcttct
     1441 gtgtagatta caggaatata cataacttta tcttcaccga atacatttga tgaaattttt
     1501 aaaacatcta atccctttgc taaattcata atttttctcc ttataattac ttaattagag
     1561 gtcaatttaa ttaaagaaat tgagaaaatg tagattttcc tctagttata ttttattaat
     1621 taaaaattat taatacctag tatatcattt aagttgaagg attactcgac ttgatttttt
     1681 tgttatttta tggtatagta attaatatag aagtaagtaa ttgcaagctt tgcaattact
     1741 tttatttttt tctaataact attttatttt tgataattcg tataaaatta aaagtaaagt
     1801 aatatagaaa atatgaatat agaaaaactt taataagaaa ataaattatg aataaataaa
     1861 agaaacgcaa tactgtatat agatgattat ttagaaaaat aaaatctctt ttaataaaaa
     1921 taagcttcaa aataaacttt tagttcataa agcttaggag taactaaatt gagtgcaagt
     1981 gtatctactg ttcaaaataa atagttcata aagcactctt ttttatatta aatcaattat
     2041 attttcgtca tttcagcaat gaaaaagaag cttatctcta ttttgagaca gcttcttttt
     2101 attaacgtcc tactttttat tagttttcta aaattaaaaa gctttattta taggattcct
     2161 tagatttata ttttgacgat ataatttttt aaaaacacct taaaagatgg tatacaatac
     2221 acacaatcat actcataatt gaaaaataat caatggaaaa caaaattact ggatattccc
     2281 tattaaaaaa tacaaattga ttcacaagaa acatataatc tataatatta tgatgttact
     2341 ctcccacacc aagtaacttt attttcaagt aaccttttca taccatctaa cttcactcaa
     2401 taaaaatggc aatataaata tatactctat tttttacttt taaatatctg acaagcttta
     2461 tatactattg gaagtaagat acaaagtaaa acagcccaat ctggtaaatg tggcatataa
     2521 aagtccccct taccttatac aagctcctta ttactaaaaa ttttaataga aataaacatt
     2581 gaagctaaca gtataattaa acttaaaagg aacaatacaa tattcactat catggatgga
     2641 tactgatata taaatggaat ttcaaaattg ctgtgagcta tagttaatgg taatacaaat
     2701 gatgaagcca tgattatcac cacgaaaaag aattttgttg tttcatatcc taatttatat
     2761 tgaataggca tataaactcc ataaataata gaacttatta ataaaacaat caaaatatat
     2821 gttaagtcaa aagttcctat ttgtggaata agtaaatttt caatccagta aactaatgta
     2881 caatagataa ataccattgc aaataaaaca tacttagatt gaactaagcc acgtctagga
     2941 taaggagttg aacaaagtaa tacagatgct tttgaatatt gactctcctt taataataga
     3001 tactggcaca gcataaattc tgaaaatata atggatagta caaatcccaa tatttgtgca
     3061 aatggaggta aacgccacaa tataaataat gggattccta ttgcaataaa taatatcaac
     3121 aatacatatt tttttacaat cagaatatct tttttaacta aatgaatcaa cataattact
     3181 ctctcctttc aatatatgca agcataatat cttcaattgt aggacgctct attaaaatat
     3241 ctggcatatt tttttgcact tcattaattt ttgaggtaat ccctataaaa ccatagccgg
     3301 taatttctaa atttaaaaat aattttttgg tttcatcatt tagaaattga atatctcctt
     3361 ttacttttct atgttcgtcc aatagagtat ctttttcacg ctctaatata atacgtccat
     3421 tgtcaatcat aacaatcata tctgctattt tgtctaaatc agatgttata tgagtggaaa
     3481 agaaaacacc acgaccacat ttcttcatat attctgttag tatgtcaagt atctgactac
     3541 ggattagtgg gtctaagcca cttgtaggct catccataat taaaaactca gctttatgcg
     3601 ataatgctaa tgctaaagca aatttcattt tcattccttt tgaaagtgta tcaatctttt
     3661 gttttgggtt aagattaaaa cgcttcatat tttgttgata atcttcttca caccaattat
     3721 catatgaagg tgcaataata cttttcattt ctgccattga caactcctca tagaaatatg
     3781 aatcatcaaa tacaactcca attcgatttt ttaattcctt ctcatttcca tcgaaatctt
     3841 taccaaagat ttttattttt ccactatcac gctttacgac atccaatatc gaacggattg
     3901 ttgttgtttt tcctgctcca ttaacaccta taaatccagt tatacaatct tctggtaatg
     3961 caaagcttat attagataat gaaaaatcgg tataagtctt atttaagtta taaacttcta
     4021 aaatattttc catattaatc ctcctgatat agaatatcca tcatttcttg taactctatc
     4081 tgtgtaattc ctagtgcttt tgcatcctta atcatatctg ccattttttg ttcaactata
     4141 cgtctctttg agtctcttag tatttctaaa tttccagttg aaataaatgt tcctattcca
     4201 acttggcgtg taagaaagcc ttcattttca agttcttcat acactcgtct aatagtcaaa
     4261 atactaactt ttaaatcatt agcaaaattt cttatggatg gcattgcatc cccttctttc
     4321 agttcttcag taaatattgc ttctttaatt tgctctttaa tttgttggta taatggctta
     4381 tctgatgtgt tagaaatgag cactttcatt ttttatcacc ccctttttat catcttcagt
     4441 gtgatgttgt tatatacaca ctatacactt agagcacttt tttgtcaata taaaagatgt
     4501 aaaatattac tatgacaaaa taaatatgaa tgaaatatta gagattgtta atagccataa
     4561 acacttttta aaaccacata agatagaatg tattaaatat ttattaaaag taagaattga
     4621 atatctaaaa gaaaaagtaa tcctgtatga atgatttgtt tgatgataaa ttaagttata
     4681 aactatttat aaaaaacata aaggaataaa tccatttcta attacaaaca tactaaaaaa
     4741 tttagatagt aataaataga tagtaataaa tgggatgaat ttataagaat ttggatagag
     4801 gaaagagtta ttcaagagtg tagactagag gtaaactcta tataaaaaaa atttaaattg
     4861 ggatattatt atgtatggaa tatttgcaga aataaccttg ctataagtat agaagatttt
     4921 tttgattaca aaagataata ctctaaaatg tgaggatttc aacattcaat actgtgcttt
     4981 aaataatatc actccaaaat accatccacc ttttactata attgaatacc ctaattattt
     5041 taaaaaggaa aacattagaa acggaaaacc ttgtatatat aaaataaaaa atactaactt
     5101 ctaaaacacg gatactcttt gataaataaa acaaaaaata attttaataa ttaaaattgg
     5161 ctatctcaaa ctagagataa gtctctttct cacttttaaa acgttgaaaa tatattcgat
     5221 ttcgtacaaa aaagagtgcc ttagaactaa aaagttcact ttgtggcact cccttttttc
     5281 tcctcttttt aattttttat aaaaattctt caaaaatatt attaaatacc ctatattata
     5341 cataaatcaa attaaagttg cattttagca aataaaaaca aattataact attagcatag
     5401 caaataaaaa atctgctctc ttataaaatc aaaattataa ttataaaaag aaaatattct
     5461 tataacaaat taactaatat aaaattattt tataaattaa tactactttt tagcttctcc
     5521 tataaattaa caccactttt ttaactatga aacctatcta caacattggt accataagac
     5581 cagctaccac aatagaaatc atacaagcca taccaccaac taccagctta ggcataatct
     5641 tagacatcaa atatgctctt tcttcttccg tttctccaac agcattacac acttcatttg
     5701 aaattaaata tgtagttggg aatcccaaca tctgacaaaa ccctactcca aaagcaagag
     5761 gtttagaacc gataattttc caacctggta acaccttcat cataaggaat ataccaatga
     5821 tagaagctgc aaacataccc acaattggta caaaaagact aattaaatct gtcaaagaaa
     5881 cttttgctaa agaaggaata acagctgcaa acacaaccat gttgataaat cccttgattt
     5941 ttcctttttc caaaatgtct tttggtacaa taccaatacg tgttacaata acaccaacaa
     6001 caagacatac aatagaataa tttacatgaa taatctctga aagttcatac cctagataag
     6061 agaatagtgc tataaaaaat atacaaacat ttgtagaata atatttatcg tatttttcac
     6121 agaaagcttg ttttactttt gtgcctgtat tctctgcttc tttcttatca gtatcaacat
     6181 ttgctaaatc aatgcctttt gattttgctt catgatattc tactaaaaga cggtttgcct
     6241 cttgtaacgc tgctcttgaa gctattggtg taccaataaa cttctgaatt gcaaatacaa
     6301 ctgttgctgt agctgctgca agtgtcagtc ctttttctag tgctgcttgt gtcataatag
     6361 tagtagcagg taaagctcca tttataactg gtatgcttgt caatactgtt gattttccaa
     6421 acaaaggaat acataatgag acacagacta taactgctac aattccaagc catgctgtca
     6481 atactgttct ccattcgtct ataaattgtt taacattcaa cattgttccc atactaaaca
     6541 taatcattgg aacactccaa ctagctgctg cggtcatacc tgctttttca ataatatcag
     6601 ctggtattgc ttttgtgaca aatagaatca aaaataaaag tagtgtaaca aatacagctg
     6661 atacttttgc ttttgttttg cttgcaatta aatccccaat agcaaataaa actaatacga
     6721 cactaaacca taataacata tcactcatag aataaccccc ttattataaa tatctttcaa
     6781 accaatctac aatagcattt gctcttgcaa ttctattaga tggtcttcca tttctagaca
     6841 atccatgtgt atctccgtga aacaaataca tttctgtatc tacaccaagc tgttttaatg
     6901 ctgtaaacat ttggaaagta tcccccataa aacatctata atccctatcg ctatgtaaga
     6961 acaatgttgg tgtcttaaca tttttcacat atttaatagg tgaatgattc caaagaacct
     7021 cctcatgatt ccaaggcgtc ttatctccac aagtctgctt cataattcta tctccaaagt
     7081 caataattaa agaagctgta atcaagttac taatacctct ttgagaagct gctgctttga
     7141 aacggtctgt atgaccaatt atccagtttg tcatataacc accgtaactt ccccctgcaa
     7201 cccctaagcg gtctgcatca atcccaggat atttttcaat acaagtatct acaaattcca
     7261 taagatgctc atagtcaaca tacccccatc tttctaccat ttctaagaac ttttcaccat
     7321 aaccgtcacc accatgaggg ttacaataaa tcacatacat tccctttgat gttacacact
     7381 gcttcaagtg tgtaaacata tagccatatg cccatttagg cccaccatga atgaacaata
     7441 cagcaggata tttttcgcct tctttagcat ctataggtgg tataacaaaa ccatcaactt
     7501 cttctttatt ttttgctaca aacgtcaatt tttcaggtaa tgaaacctta tgagtatcta
     7561 aatatggttt agaaaaagca gtcatttttt tcattgtacc tgtagtcata tcaatgctat
     7621 atatttctgc taactcataa tctttcaaca ttactgtgta catggtgttg tcgtaaatat
     7681 caaaagatgt aaaagcatct acttttgtga tgatacgtat attacctgtc tttgtatcaa
     7741 actcattaaa ttctgtcata gttctgcaaa ttcttgcacc aataaattta tctcctataa
     7801 ctttattact acgtccacca ccatatactg catctacatc cagcaatgta gcatacatac
     7861 catctggact agcaatcata tttatttcat tagtactcaa atcaagtata aaaatatcat
     7921 gattctgtgt gatagaacgg tctaatgttg aagcttgcaa cattacttta tctttgccaa
     7981 tatattttgc caaacttatt tggtactttc cttgtggtac aagttctttg gtttcaccac
     8041 tgtctatatg atactcccaa agtccagaaa aaggagttgc acaatcttca taaatctgac
     8101 cagtatataa aattctgttt ttatcagaag aaacgtctac acctgctact tcacaaaatt
     8161 ttggtgtaat ggcttttgtt atattttcac cttcttgata taattctaat gttacacgtc
     8221 ttctttgaga aaaattttct ccatctctta taaaaggttt atctgtaaat gtccaataat
     8281 ctacaccctc tactgcccta tctggttctg attttttaga atccgttgga ttttttgttg
     8341 tcagtaacca caatttattt ccaagtgata caggtacgct acaagctttt ggaatagaaa
     8401 atgctttttt tgcttctcct ccttctatag aaatagtgta aaaatctgtt gtacctgatt
     8461 ttggcttatt tcttttagat gtaaaaagga gttctgtatt agaaatccaa ctaaatgatg
     8521 ttacatcttt tgtttgagtc atatgtattt gtttttctgt tttgatgtcc atcacatata
     8581 agtcatgttc atagcagtct ttttcctcgt tgatatttga tataatataa gcaatatgct
     8641 ttccatcagg tgaacaagaa atatcatgag ggaatatata ttcaaaaata tctgaacttt
     8701 caatctttat tttttccatt tttatattct cctttctact gtcctatgtt atcttttttt
     8761 atatataccg aaaaccaatc tagcatttca actaatcttt gtagcttttg ttttggtcta
     8821 ccagaacgag acagttcatg gttttctcct tcaaatagac aaagttttgt aggacaccca
     8881 tgaattttca atgctgaaaa catctggaat gcttcttgca tatagcatct atagtctttt
     8941 tcaccatgta aaaataaagt cggtgtaaca catttatcag cataagcaag aggtgactgt
     9001 ttccattgaa gctcgtggtt ttccatatga gaagcacctg tttgtccttt gcagaaataa
     9061 taaccaatgt ctgttgtacc ctccatgcca ctccagtttg caatagaacg ctgagcacaa
     9121 gcaacagcaa aacggtttgt atgaccaatt atccaattcg tcataaatcc accataactt
     9181 ccaccttcaa cagccaattt tgttttatca atgtctgtat atttttcaag tacagtatct
     9241 gtaaattcca taaaatctat ataatcaata tctccaaact gtttcctaat atctgcaaaa
     9301 gcattgccac gaccttcaga cccccttggg ttacagaaga atacaaagta acctgcactt
     9361 gtaaatacct gtatctcatg cataaaatat ggtccatatg tcaatcttgg tcctccatga
     9421 atcgccaata cagctggata ttttttcccc acctcataat ctactggttt atatacgtat
     9481 ccttgtattt cccatttaga acttcctttt gactctatgt attctggcac agaaatttta
     9541 tattcctcta aaatatggtc atttaaatgt gttttcttac acaatgttcc attctctact
     9601 gtataaactt ctggtaatcc atttcctaaa caacccacac atacaatatt gccatctttt
     9661 acatctataa aatcaactga acctgtctgt gttacttttt cctgttttcc tgttggaata
     9721 tgtattcttt caataatgca gtccatatct actgtagaag tgtaataaat atattctcca
     9781 tctacctttg ttgtctgacc agcacccatt ttaacatcag atgttactgt atttccaata
     9841 caatgatgtt gatgccctga aagaagtttc atttctttcg tatcaatatc aatagtataa
     9901 aaatctccat tttctccatt tccataagat aaagcatcag ttaggtttag tatcacttga
     9961 ttttgatata attcaaaacc ttttataata tacttatctt tttctaatat acagacattt
    10021 gtgtttgtgt ttgtatcaaa tacatagacc ccatttttca aaccttttac atctttaaac
    10081 tcttgcccta tatataagat ttttccatca cttattttca tacctacaac attaaacata
    10141 ggtgctgtaa ttgccttcaa ctcatttata ttactgtcgt atatatatag gcgttttctt
    10201 tttctgctaa tatatccctc cccattgaca gcataaggaa tttctttgaa atgttcataa
    10261 tgtcttttgt tataagcatt tatttttttc tgttgttctt cttctggcaa tccctctaca
    10321 ataggtcggt cattgtcata agaatcaata actgcataca aaccttttcc tataggattc
    10381 aatttaccac ctttgatagg gagtctaaaa agttcttctg cttctccacc atttaaagat
    10441 aaagcatagt aactcatgca ttgcttaccg tttttgacag cttcttttac tttttcattt
    10501 ctcaaagcag ggaacaagat agtattttca tcttcccagg catatgctcc aacagagttt
    10561 atagacgtta tttgttttaa ttcgccagtt ttattgttta atatataaac ttggcttgtg
    10621 taaccattct ctttgatatc agcttttttt acaataaatg ctgtatatcc tccatctggt
    10681 gatatttggc aatcacttat aaattgatat tccaaaaatg tttcactcgt aaatagcttt
    10741 ttcatagtat tttctgtcct ttctttagta atttttttca aactccctac cacctctttc
    10801 attttttatt ttaaatttaa aataaaaaat tttaaattta aaataaaaaa ttttataaag
    10861 gttatttttt taggaagcct tctggcttcc ttgtaatatt tgtaatttaa agtatattta
    10921 atccatgctt aatt
//
LOCUS       DAEQCW010000116        10808 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.117, whole genome shotgun sequence.
ACCESSION   DAEQCW010000116 DAEQCW010000000
VERSION     DAEQCW010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10808)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10808)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10808
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.117"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(299..1264)
                     /locus_tag="KRO40_003028"
     CDS             complement(299..1264)
                     /locus_tag="KRO40_003028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093832.1"
                     /translation="MVMQVQEKILELLYTINEDVVSIKNDMSEVKQEINVLKEDMSEV
                     KQEITVMKEDMSEVKQEINVLKGNMSEVKQEMIVMKEDMSEVRQEINIMKEDMSEVRQ
                     EINTMKEDMSEVRQEMTVMKEDMSEVKQEINVLKEDMSEVRQEINIMKEDMSEVRQEM
                     TVMKEDTSEVKQEINVMKKDMSEVRQEITVMKEDVSEVKSEVNFMQNKINNINEDMNG
                     IKDEVSIANEKLYGIEIKIDSLECEDKSMKEIQIEQNNILGSLLHNSEINKATHDNIE
                     HNIAYIKGDTNSIKEDIAEIRRDLNLVELATSKNWSDIVKLKSVK"
     gene            complement(1494..2579)
                     /locus_tag="KRO40_003029"
     CDS             complement(1494..2579)
                     /locus_tag="KRO40_003029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBH2093833.1"
                     /translation="MYNFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIR
                     KERAINPAPHMVRNTANALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCIASIGHTIEE
                     SSELVEKVANAGADFIELVSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAKK
                     LEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRIYEIKKQV
                     NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRLGYN
                     TIENACGIVHNHMGDVNERLSFEFTYDEEKCTKCKMCERVCAYQARKLNDKMELNEEE
                     CRYCGLCISVCKPKALGRKISCSELNV"
     gene            complement(2615..3928)
                     /locus_tag="KRO40_003030"
     CDS             complement(2615..3928)
                     /locus_tag="KRO40_003030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH2093834.1"
                     /translation="MIAIKSKYLISSADEIYANSAVVVENDIIKDILPNEEVEIKYKN
                     IEEIIDKSDAIIMPGFVNGHMHQYGVLSRGIPANVHFTDFEGFLNDYWWPFIENRIGL
                     KEVKATTKASAIELIESGVVAFCDTLEAPNTEEGTLIEQGKILEEIGMKAILSLESCE
                     RISFENGLRCLDENSNLIKWSRENSKLINGIMCTHTSFTCSDRFIKKAKEDAKKLNSP
                     MQFHLCESIYEPNYAEKHFGKKAVDYYNDLDILDETILASQCVKVNDEEIDILKEKGV
                     KVVHMPLSNCEVGGGFSPVPKMIKKGIKVALGTDGYINDFFEVMRGAFLMHKSVEEDA
                     SVMPANLVFRMATEHGAYVLGLQNSGKIAVGNKADIIVMEDEFKTPVTLDNIFDQIVV
                     QGKKEFISNVYIDGRHILKEKQLVDLDKKAIVKEMKEVACEFWKF"
     gene            complement(3929..6220)
                     /locus_tag="KRO40_003031"
     CDS             complement(3929..6220)
                     /locus_tag="KRO40_003031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2093835.1"
                     /translation="MVNKEVRKIDSEAIVTGKPIYTEDLIFHKDVLTIKLLRSPHAFA
                     KIKNIDIKNALKVKGVVNIFTYKDVPNYRYSMVGESYPEASPHDQLILEDVVRYVGDE
                     VAIIAAEDERAAIKAMKLIKVEYEVMTPILDARESEGNKILIHEEDDLFCPFDFGLDA
                     TKNIVSREKMGKGDVEKEFKESDVIVEHSYMTQSQAHCMMETHRAYTYIDTNGRLVVT
                     SANQSAYHMRRQVSKALGIPLSKVRVIKPRIGGGFGGKNIAVTEIYASFVTWMTKRPA
                     KLIYTREETFAMTNTRHQMFFDIKIGADKEGNIKAIDMKALNNTGAYGDNGPSVCSES
                     GHNVLPTYNNVPAIKFDGRTVYTNLVPGGALRGYGATQGTFALDCAIDELAHKLNMDP
                     TEIKLKNIIKKQTEGGIMNFPIRSCALDECIIRGKKLIGWDEKYPVRDIGNNKVRAVG
                     MSVGTHGSGIANIDMAIVNMRMDEDGTYKLFSGSSDLGTGSDTILAQIAAKALNTSID
                     RISVYTGDTDMCPYDTGAYASCTTYVTGNATIKSAESLKQKILKVAQKKLDLPIDDLI
                     LYEDRVCYSEDVEKFVLLSELGKESVGGGNQEVLYSSESYGIQESAKPFLAGFAEIEL
                     DKTTGEFKVINYACSTDCGTVMNPALARIQVEGGVTQGIGLAMYEDPRHGSDGKLQTS
                     NLLQYKVPTKKDIGNIIVDFVDNYEPTGPYGAKSLGEIVIHTPAPAIANAIYNATGVR
                     IRELPITSEKVYMAMKKLNQGGK"
     gene            complement(6210..7004)
                     /locus_tag="KRO40_003032"
     CDS             complement(6210..7004)
                     /locus_tag="KRO40_003032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH2093836.1"
                     /translation="MITIKEYVVPKSLDEAYELLISRKNNIILGGCGFLKLGSKNIGS
                     AIDLKDLALDYINETDDSILIGADTSLRTLELNKVIKNYCNGVISNAVSNIVGVQFRS
                     GARVGASVFAKYGFSDLIPSLLVVDAKVKLYKKGVMNLADFLESELEKDILIEVILPK
                     KDAIGVFDSIRKCTGDFAVLNGAMLKEGSIYKIAIGARPRRAKIAYKASEILSLENDI
                     EKAGEVSSEELSFGSNIRGSKEYRKDMAKALVVRMYNSIGGECDGK"
     gene            complement(7043..7489)
                     /locus_tag="KRO40_003033"
     CDS             complement(7043..7489)
                     /locus_tag="KRO40_003033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBH2093837.1"
                     /translation="MIIKCTINNKEKELSIRPDDFLADTLRENGYVSVKKGCDTGSCG
                     LCTVMVNDKAVLSCNYLTARVDGQHITTLEGVLDEAKKFGDFLADEGADQCGFCAPGF
                     IMMVLAMKRELQNPTEEEVIDYVNGNLCRCTGYKGQLRAIHKYLNT"
     gene            complement(7561..8967)
                     /locus_tag="KRO40_003034"
     CDS             complement(7561..8967)
                     /locus_tag="KRO40_003034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBH2093838.1"
                     /translation="MMDILIKNAIIVTVNKEREVIFDGALVVKDNKIADIGNSKEIES
                     KYTDVKKIIDAKGKVLFPGFINTHNHLFQTLLKGLGDDMVLKDWLETMTFPAANYLEP
                     KDTYDAAMLGCIEGLRSGITTMVDYMYPHSKPGLCDGIIDAYKELGIRGILGRGCMNT
                     GAQFGVHPGIMQDVETVEKDVRRLFEKHHNTENGRIKIGVAPAAIWSNSQEMLEMLWR
                     VVKEYDDALFTVHISETPFDREAAKELHGQYDIDVLEKLGILGPNVLMVHCVYLTEKD
                     MELTKKYDMKVSHNTASNMYLSSGVAPVPEMLKKGITVSLGVDGAASNNSQDMLELMK
                     LTALQHKVNKCDPLAMSAEKVLELATIDGARAIGMEDEIGSLEIGKKADLLIFNPMLS
                     PKAIPMHNPVSTLVYSSSMKNIESVIVDGNIIMEDSKILTANEEKALKDAQDTAERLC
                     VRGTIKNRMEGHKWNSLY"
     gene            complement(8985..10355)
                     /gene="hydA"
                     /locus_tag="KRO40_003035"
     CDS             complement(8985..10355)
                     /gene="hydA"
                     /locus_tag="KRO40_003035"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBH2093839.1"
                     /translation="MGTILRGGTIITSDKTYISDLRIEDEKIVEIGNNLEINGDKVID
                     ATGKIVIPGGIDTHTHFDMNAGSITTADNFETGTRAAIAGGTTTILDFAEANEGEDLL
                     QGVEAYHKKASGNCYCDYGFHMTITCLNKDTFNHMEKLISDGIVSFKMYMAYDGMKVD
                     DGTIYRVLKKARDLGCIVGFHCENGDLLDVLIEENIQNGNLEPKYHPLTRPNIVEKES
                     VSRLADITKLSNSKSYVVHLSCRESLETVKMAREKNIDMIVETCPQYLLLEDNLYNKD
                     KFEGAKYVMSPPLRKKEDINYLWEGLSSGDIQTVGTDHCSFNFKGQKDLGIDDFSKIP
                     NGAPGVEHRLALLYTYGVLENRISVNKFVEVTSTNAAKIFGMYPKKGEIAVGSDADIV
                     ILNINKEETISYKTQKQNVDYTPYEGFKVKCKVEDVFLRGNHVVQSCNVKEHPTGQYI
                     KRKITK"
     gene            complement(10488..>10808)
                     /locus_tag="KRO40_003036"
     CDS             complement(10488..>10808)
                     /locus_tag="KRO40_003036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2093840.1"
                     /translation="VEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDS
                     EITQYSFCTNGSHYAGEAGIKTIGFGPSKENLAHTIDEYIEQEQLFIGTEGYYGILKS
                     VYGK"
BASE COUNT         3149 a         2174 c         1131 g         4354 t
ORIGIN      
        1 tagagcaatt ttagtgccaa tatttgcata catttgtata gtataaaatt tttatgttct
       61 cattgataaa attttactta tttcaagcgt tctattagat tttatcatct aaattttagg
      121 ttttattttt ataaattaat tgtatttaca taaaaaaaaa gacctaaaac aaatttttaa
      181 cggtcttttc tcaatttttt attttcattt ctaaaattta taataaatag taagaacact
      241 ataaattctt ttatataaaa ttcttagttt gtggatgata aattagtgaa ttaaaatact
      301 actttactga ttttagtttg acaatatcac tccaattttt actagtggct aactctacta
      361 aatttaagtc tcttcttatt tcagctatat cctcttttat agaattagtg tcacctttta
      421 tatatgctat gttatgttct atattatcat gagtagcttt atttatttca gaattatgta
      481 ataaacttcc taaaatatta ttctgttcta tctgtatctc tttcattgat ttatcttcac
      541 attctagact atcaatctta atttcaattc catataattt ttcatttgct atggatacct
      601 cgtccttaat tccattcata tcttcattaa tgttatttat tttattttgc ataaagttta
      661 cttctgattt aacttcggaa acatcttctt tcattacagt tatttcttgt ctcacttctg
      721 acatgtcttt tttcattaca tttatctctt gttttacctc tgatgtatct tctttcatta
      781 cggtcatttc ttgtcttact tcggacatat cttctttcat tatatttatc tcttgtctta
      841 cttcggacat atcttctttt aatacattta tctcctgttt tacttccgac atatcttctt
      901 tcattacagt catttcttgt cttacttccg acatatcctc tttcattgta tttatctctt
      961 gtcttacctc ggacatatcc tctttcatta tatttatctc ttgtcttacc tcggacatat
     1021 cttctttcat tacaatcatt tcctgtttta cttctgacat atttcctttt aatacattta
     1081 tttcctgttt tacttccgac atatcttctt tcattacagt tatttcttgt tttacttccg
     1141 acatatcttc ttttaacaca tttatttctt gttttacttc cgacatatca ttttttatgc
     1201 taactacatc ttcatttata gtatataata actctaaaat cttctcttgc acttgcatca
     1261 ccatccctat taattattat aacattttac acaaatgcta tacaatgtta acatatatat
     1321 cagaattatt aaaattttaa ttaaacaaaa ttgattcact ttattacttc aaaactaatt
     1381 aatatctaaa ataactacaa ataaacaaaa ataaggtcaa caacaaaaaa ggcttatctc
     1441 tttgagatag cctttcttat ttttatttaa aactttgttt tttataaaat aatctataca
     1501 ttcagctctg aacatgaaat ttttcttcca agtgcttttg gtttacaaac tgatatacaa
     1561 agtccacaat atctacactc ttcttcattc aattccatct tatcattcaa ttttctcgct
     1621 tgatatgcac aaactctctc gcacatctta catttagtac atttttcttc atcataagta
     1681 aactcaaagc taagtctttc attaacatct cccatatgat tatgtactat accacaagca
     1741 ttttctatag tattatatcc taatctatta agattagatt ttaaatcatc atgtatttta
     1801 gatattactt gtgcgccttt taaaattact actgaacata taccaacaaa gtcagcacct
     1861 gccataatca tttctaaggc atcatctcca cttacacatc cacctaagcc aattattggt
     1921 atattaactt gtttttttat ttcatatatt ctctgtaaag ttattggctt gatagtttct
     1981 ccacttaaat atcctattcc atttccacct aataaaggtt gccctgtttc tatgtctatt
     2041 ctaaatgctg gtcctacaga gtcacaagca gttattgcat ctgctcctgc ttcttctaat
     2101 tttttagcaa aatcgcctat ctcatctatc ataggaggaa gtttaactat tacaggtata
     2161 tttactcttt cctttgcatc tttaagcatt ggtatcaaat ctctatagtc ataagatact
     2221 aattcaataa agtcagctcc tgcatttgca actttctcta ctaattcgct actttcttca
     2281 attgtatgac ctattgaagc tatacagaca gtcccatctc ttttcatttg tggtatttca
     2341 aaatctatcc attgctctgg ctcaaaatct gtccattttt cattatttaa aagagcatta
     2401 gctgtatttc taaccatatg tggtgctgga tttatagctc tttcttttct tatagtctta
     2461 gtcacaactg cccctgctcc tgcatcactt aatatcttgc atccagctgc actatatgtt
     2521 aatggtcctg aacctattat aagtggtgat tttaattctt tacctaaaaa attatacatt
     2581 atctgcttcc ccttttcata tatatttata ttcgttaaaa tttccaaaat tcacaagcaa
     2641 cttctttcat ttctttaaca atagcttttt tatctaaatc aactaactgt ttttctttta
     2701 aaatatgtct accatctatg tatacatttg atataaattc ttttttaccc tgaactacta
     2761 tctggtcaaa tatattatca agagtcacag gagttttaaa ttcatcttcc ataactatta
     2821 tatcagcctt attaccaact gctattttac cagaattttg aagtcctaat acataagcac
     2881 catgctctgt tgccattcta aatactaaat ttgctggcat tactgatgca tcttcttcaa
     2941 ctgatttatg cattaaaaat gcacctctca taacttcaaa aaaatcattt atatatccat
     3001 cagtacccag tgccactttt atgccttttt taatcatttt tggtactgga gaaaaacctc
     3061 cacctacttc acagttgcta agaggcatat gaactacttt tacacctttt tcttttaata
     3121 tatctatttc ttcatcattt acttttacac actgagatgc taatatagtt tcatccaata
     3181 tatctaaatc attatagtag tcaactgctt ttttgccaaa atgtttttca gcatagtttg
     3241 gctcatatat actctcacat aaatgaaatt gcattggtga atttaatttt tttgcatctt
     3301 ctttagcttt cttaataaat ctatcagaac atgtgaagct tgtatgtgta cacattattc
     3361 catttattaa tttactattt tctctactcc actttattaa attagaattt tcatctaaac
     3421 atctaagtcc attttcaaag cttattcttt cacaactttc taaggataaa atcgctttca
     3481 tgcctatttc ttctagtatt tttccttgct caattaaagt tccttcttct gtatttggag
     3541 cttctagggt atcacaaaaa gctaccacac cagattctat aagttctatt gctgatgctt
     3601 tagttgttgc cttcacttct ttcaatccaa ttctattttc tataaatggc caccaatagt
     3661 catttaaaaa accttcaaag tcagtaaaat gtacatttgc cggtattcct ctagaaagaa
     3721 ctccatattg atgcatatga ccattgacga atcctggcat tattatagca tctgatttat
     3781 ctattatttc ttcaatattt ttatatttta tttcaacttc ttcatttggc aatatatctt
     3841 ttataatgtc attttctact acaacagcag aatttgcata tatttcatca gcagaagata
     3901 ttaagtattt acttttaata gcaatcattt atttacctcc ctgatttaat tttttcatgg
     3961 ccatataaac tttctcagaa gttataggaa gttctcttat acgaactcct gtggcattgt
     4021 atattgcatt tgctattgct ggtgcaggtg tatgaataac tatctctcct aaagatttag
     4081 ctccatatgg acctgttggc tcataattat ctacaaaatc aacaattatg tttcctatat
     4141 ctttttttgt tggaactttg tattgtaata gattagaagt ttgaagcttt ccatcagaac
     4201 catgtctagg gtcttcatac attgcaagcc ctataccttg agttacacca ccttcaactt
     4261 gtattctagc aagtgcagga ttcataactg taccacaatc tgtagaacaa gcataattta
     4321 ttactttaaa ctcccctgtt gttttatcta actctatttc agcaaatcct gctaagaatg
     4381 gtttagcact ctcttgtata ccataagatt cagatgaata taaaacttct tgatttccac
     4441 caccaacaga ttcttttcct aattcactta acaaaacaaa cttctctaca tcttcactat
     4501 aacaaactct gtcttcatat agtattaaat catctattgg taaatcgagt ttcttctgtg
     4561 ctacttttaa tatcttttgt tttaaacttt cagcagattt tattgtagca tttccagtta
     4621 cataagtagt acaagaagcg tatgcaccag tatcatatgg acacatatct gtatctcctg
     4681 tataaacgga aattctatca atagatgtat tcaatgcttt tgcagctatt tgtgcaagta
     4741 ttgtgtcaga accagttcct aagtctgaag acccagaaaa caacttataa gttccatctt
     4801 catccatcct catatttact attgccatgt ctatgttggc tataccagaa ccatgagttc
     4861 ccacagacat tccaacagcc ctcaccttat tgttgccaat atccctaaca gggtactttt
     4921 catcccatcc aataagtttt ttacctctaa ttatacattc atcaagtgca caacttctta
     4981 ttggaaaatt cattattccg ccttcagttt gtttttttat aatattcttt aactttattt
     5041 ctgttgggtc catattaagt ttatgcgcta attcatcaat tgcacaatca agtgcaaatg
     5101 taccttgtgt tgctccatat cctcttaatg ctcctcctgg aactaaatta gtatatacag
     5161 ttctcccatc aaattttatt gcaggtacat tattatatgt tggaagtaca ttatgacctg
     5221 attcagagca aactgaaggt ccattatcac cataagcgcc tgtattgttc aatgctttca
     5281 tatctatagc ttttatgttt ccttctttat ctgccccaat ttttatatca aaaaacatct
     5341 gatgtctagt attagtcatt gcaaaagttt cttctctagt ataaattagt tttgctggtc
     5401 tttttgtcat ccaagttaca aatgatgcat atatctctgt tacagctatg ttttttccac
     5461 caaaacctcc acctattctt ggttttatta ctctcacttt tgaaagaggt attcccagtg
     5521 ctttagaaac ctgtcttctc atatgataag ctgattggtt tgcagaagtt actactaatc
     5581 tgccattcgt atctatatac gtataagctc tatgagtttc catcatacaa tgggcttgtg
     5641 attgagtcat ataagaatgt tctactatta catcactttc tttaaactct ttttctacat
     5701 cccctttacc cattttttct ctcgatacaa tattttttgt agcatccaat ccaaaatcaa
     5761 atggacaaaa caaatcatct tcttcatgga ttaaaatttt atttccttcc gattctcttg
     5821 catccaatat aggagtcatt acttcatatt caacttttat aagtttcata gctttaatag
     5881 cagccctttc atcttcagcg gctattatag caacttcatc tcctacatat ctaactacgt
     5941 cttcaagtat taattggtca tgaggtgatg cttctggata tgactctcca accattgaat
     6001 atctataatt tggaacatct ttgtaagtga atatgtttac tacacctttt acctttaatg
     6061 cattttttat atctatgttt tttatcttcg caaaagcatg tggacttcta agaagcttaa
     6121 ttgttaaaac atctttatga aaaattaaat cttctgtata tattggtttt ccagtaacaa
     6181 tggcttcact atctattttt cttacctctt tatttaccat cacactcacc tccaatacta
     6241 ttatacattc tcactactaa ggcttttgcc atatcttttc tgtattcttt acttcctctt
     6301 atattacttc caaatgaaag ttcttcactt gatacttcac cagctttttc tatatcattt
     6361 tctaaactta atatttcact tgctttatag gcaatttttg ctcttcttgg tctagcgcct
     6421 attgcaattt tataaatact tccttctttt aacattgctc catttaatac tgcaaaatca
     6481 cctgtacatt ttcttataga atcaaataca cctatagcat cttttttagg taatataact
     6541 tctattaata tatctttttc aagctcactt tctaaaaaat cagctaagtt cataacccct
     6601 tttttatata acttaacctt tgcatctacc actagtaatg aaggtattaa atctgaaaat
     6661 ccatacttag caaatacgct agctcctact ctagctccac ttctaaattg aactcctact
     6721 atattagaaa cagcgtttga aattacccca ttacagtaat ttttaataac cttatttaat
     6781 tctaaagttc ttaaacttgt gtctgctcca attaatatgc tatcatcagt ttcatttata
     6841 taatctaaag ctaagtcttt taaatctatt gctgatccaa tatttttact acctagtttt
     6901 aaaaatccac atcctccaag tattatgttg ttttttcttg atattagcag ttcataagct
     6961 tcatctaaac tttttggaac tacatattcc tttatagtta tcatactctc tccccatatc
     7021 aacttaattt tcacttaaaa gtctaagtgt ttaaatattt atgtattgct cttaattgac
     7081 ctttatatcc tgtacatcta caaaggttac catttacata atctataact tcttcttctg
     7141 ttggattttg aagctctctt ttcattgcca aaaccatcat tataaatcca ggagcacaaa
     7201 atccacactg gtcagcccct tcgtctgcaa gaaaatctcc aaacttcttt gcttcatcca
     7261 agacaccctc aagtgttgta atatgctgac cgtctactct agcagtaaga taattacatg
     7321 aaagcacggc cttgtcattt accatcactg tacataaccc acatgagcct gtatcacacc
     7381 cttttttaac acttacatat ccattttctc ttaatgtatc tgctaaaaaa tcatctggtc
     7441 ttatacttaa ttctttttct ttattattta tggtacattt gataatcaaa taaatcacct
     7501 caaaactcat atttttaagc taaagtttta ctatactttt ctatgaataa attacattta
     7561 ttaataaagg ctattccatt tatgaccttc cattctattt tttatagttc ctcttacaca
     7621 aagtctctca gctgtatctt gagcatcttt taatgctttc tcttcattag ctgtcaatat
     7681 ttttgaatct tccattatta tatttccatc tactataaca ctctctatat ttttcatact
     7741 agaagaatat actaatgtag atactggatt atgcataggt atcgcttttg gtgaaagcat
     7801 tggattaaat attagtaagt ctgctttttt acctatctcc aatgaaccta tctcatcttc
     7861 cattccaata gctcttgctc catctatagt tgccaactca agaacttttt ctgctgacat
     7921 tgctaatggg tcacacttat taactttatg ttgaagtgct gttaatttca taagttcaag
     7981 catatcttga gagttattac tagcggctcc atctactcct aaactaactg ttattccttt
     8041 tttaagcatt tctggcactg gtgcaacacc tgaagataag tacatattac ttgctgtatt
     8101 atgagacact ttcatatcgt attttttagt aagttccata tctttttcag ttagatacac
     8161 acaatgtacc ataagcacat ttggtccaag tattcctaat ttttctaaaa catctatgtc
     8221 atattgccca tgcaattctt ttgctgcttc tctatcaaaa ggagtctctg atatatgtac
     8281 tgtaaataaa gcatcatcat attcttttac tactctccat agcatttcaa gcatttcttg
     8341 agaatttgac catattgctg caggagctac tcctattttg attcttccat tttctgtatt
     8401 atggtgtttt tcaaacaatc ttcttacatc tttttcaacc gtttctacat cttgcattat
     8461 tccaggatga actccaaatt gagctcctgt attcatacat cctcttccaa gtattcctct
     8521 tattcctaat tctttataag catctattat tccatcacaa agacctggct tactatgagg
     8581 atacatgtag tcaaccattg ttgttatacc acttctaagt ccttcaatac atccaagcat
     8641 tgcagcatca taagtatctt tgggctctaa atagttagct gctggaaatg tcatagtttc
     8701 taaccagtct ttaagtacca tatcatctcc caatcctttt aataaagttt ggaataaatg
     8761 attatgtgta tttataaaac ctgggaataa aactttacct ttagcatcta taattttttt
     8821 aacatcagta tatttacttt ctatctcttt agaatttcca atatcagcaa tcttgttatc
     8881 ttttactact aatgccccat caaaaataac ttctctctct ttattcacag ttactattat
     8941 ggcattctta ataagtatat ccatcattct tatttccccc cgcattattt agtaattttt
     9001 cttttaatat attgacctgt tggatgttct ttaacattac aactttgtac tacatgattt
     9061 cctctcaaaa atacatcttc aactttacat ttaaccttaa atccttcata tggagtataa
     9121 tctacatttt gtttttgagt tttataacta attgtttctt ctttattgat atttaaaatg
     9181 actatatctg catcacttcc tacagctatc tcaccttttt taggatacat tccaaatatt
     9241 tttgcagcat tcgtagaagt aacttccaca aacttattta cacttattct attttctaag
     9301 accccatatg tatataaaag tgctaaccta tgttcaacac caggtgctcc atttggaatc
     9361 ttactaaaat catcaattcc caagtctttt tgccccttaa aattaaatga acagtggtct
     9421 gtgccaactg tttgaatatc tccactagac aatccttccc aaaggtaatt tatgtcttct
     9481 ttttttctta aaggaggaga cattacatac ttagcaccct caaatttatc cttattatat
     9541 aaattgtctt ctaataatag atactgtggg catgtttcta ctatcatatc tatatttttt
     9601 tctctagcca tttttacagt ttcaagtgac tccctacaac ttaagtggac tacataggat
     9661 tttgaattag ataatttagt tatatcagca agtcttgaaa cagactcttt ctcaactatg
     9721 ttaggtcttg taagtggatg atattttggc tctaaattac cattttgtat attttcttct
     9781 atcaatacat ctagtaaatc cccattttca caatgaaatc caactataca acctaaatcc
     9841 cttgctttct ttaaaaccct gtatattgtt ccatcatcta ctttcatgcc atcatatgcc
     9901 atatacatct taaaagatac tatcccatcc gaaataagtt tttccatatg attaaatgta
     9961 tctttattta aacatgtaat tgtcatatga aaaccataat cacaataaca atttccactt
    10021 gcttttttat gatatgcttc tacaccttgc agtaggtctt ccccctcatt ggcttctgca
    10081 aaatctagta ttgtagtagt tcctccagct atagctgctc ttgttcctgt ttcaaaatta
    10141 tctgcagttg taatagaacc tgcattcata tcaaaatgag tatgtgtgtc tattccacca
    10201 ggaattacaa ttttacctgt agcatcaata accttatcac catttatttc taagttattt
    10261 cctatttcaa ctattttttc atcttctatc cttaaatcac ttatataagt cttatcagag
    10321 gtaattatag ttccacctct tagtattgtt cccatatata cctcctaact tttaagcttt
    10381 aaagtatttt ctaagtattg taaaacttta tttaaaattg tattttctaa aggtgctata
    10441 ttcagcacct ctagactata tttaaataat ttattgtgaa ctaaatatta ttttccgtat
    10501 acagatttta atattccata gtaaccttct gttcctataa ataactgttc ttgctctata
    10561 tactcatcta ttgtgtgagc aagattttcc ttagaaggac caaatcctat agtttttatt
    10621 ccagcttcac ctgcatagtg acttccattc gtacaaaatg agtattgagt tatttctgaa
    10681 tctattccag cttcttttaa tcccttatat gctgcttgaa caaattcatc ttcttcgtca
    10741 tataaccaac ctgggaagaa tctttcactt tctatagtat ttcctgtata gcaatcagct
    10801 ttttcaac
//
LOCUS       DAEQCW010000117        10713 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.118, whole genome shotgun sequence.
ACCESSION   DAEQCW010000117 DAEQCW010000000
VERSION     DAEQCW010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10713)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10713)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10713
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.118"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            121..468
                     /locus_tag="KRO40_003037"
     CDS             121..468
                     /locus_tag="KRO40_003037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBH2093841.1"
                     /translation="MHENKKNLLDGSLAQYNDTAVPKIPVFAGNDITSEVYYFKPNQV
                     LNAHRHPNGEQIFVFLKGEGKMKLGEHECDVKNGDTVFVPTGEWHEITNGSNEEMVAV
                     QITKINAGAEYRG"
     gene            complement(618..1118)
                     /locus_tag="KRO40_003038"
                     /pseudo
     CDS             complement(618..1118)
                     /locus_tag="KRO40_003038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897038.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            complement(1145..2650)
                     /locus_tag="KRO40_003039"
     CDS             complement(1145..2650)
                     /locus_tag="KRO40_003039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH2093842.1"
                     /translation="MNVAIYLRKSRADEEAEHRGEFETLSRHKTTLLKLAREQNLNVI
                     EIKEELVSGESIEYRPKMLELLGEIKNNNYDAVLVMDIDRLGRGNMQDQGLILDTFKK
                     SKTKIITPRKTYDLNDEFDEEYSEFEAFMARKELKLISRRMQRGKIKSIEEGKFIAQA
                     PPYGYDIKYLNNKERVLVINEDKATVVKIIFDMYLKGDGACKISNYLNELGYKTTTGR
                     TWYEKGIRDIIKNKVYCGYIVWNKVERKRNSSRTRGIEEQIEVKGKHEPIISEDIWNK
                     AQNIRKKRINSPTPNNKITNPLAGIVKCGYCNHTLIAKSNTTSNGYEKYMVCTNCKNK
                     ATKLYILENKILEVLNKWLVNYRLSLKDEKDNSKPENTLEHTLTNLNKELDTLEKQKE
                     RLHDFLEQGIYDNNTFGERLKILLSRIENVREAINKTNIDIEMQKERNTVKTQIVPQL
                     EKILSEYTEEKEPYLKNILLKSVINYAVYKKEPNQKSDDFSLILYPNIPRD"
     gene            complement(2849..3703)
                     /locus_tag="KRO40_003040"
     CDS             complement(2849..3703)
                     /locus_tag="KRO40_003040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2093843.1"
                     /translation="MEWIERLNKAINYIEENITKEIEYEQVAKIACCSTYHFQRMFAY
                     MADVPLSEYIRRRRMSLAAVELQNDDKKIIDVALKYGYSSPTAFNRAFKSIHGVAPSV
                     IKKREITTLKAFPPISFKISIKGAEEMNYRIEKKEAFRIVGVSQPLHNELEKNFEIVP
                     QMWQKVALDGTLQKLIPMMDSQLQGVLGISICNNSEEWKYFISVSSTKSIDNTLEEYT
                     VPAFTWAIFSGEGQCPQAIQELEKRIVTEWLPTSGYEYDNGPDIELYLNPDPQNAKFE
                     VWIPVVKK"
     gene            4088..4369
                     /locus_tag="KRO40_003041"
     CDS             4088..4369
                     /locus_tag="KRO40_003041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093844.1"
                     /translation="MPNIEKDLDGTTTITYLNDDIGVPTDENGYKISMTILHGKTICH
                     VVSPETILGRKFTLEEKQEKDTIIYGAIEKIMVDRQLQIKNSNKEVASH"
     gene            4519..5367
                     /locus_tag="KRO40_003042"
     CDS             4519..5367
                     /locus_tag="KRO40_003042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003442793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sialate O-acetylesterase"
                     /protein_id="HBH2093845.1"
                     /translation="MIKSFLMLGQSNMAGRGFISEVTPIYNERIQMLRNGRWQMMTEP
                     INYDRPVSGVSLAASFADAWCCENQEDRIGLIPCAEGGSSLDEWNIDGILFKHAISEA
                     KFAIQSSELTGILWHQGENDSNNGNYKFYYKKLLSIIETLRKELNIPDIPIIIGGLGD
                     FLGKVGFGKSCTEYVFINQELQKFAFEQDNCYFVTATGLTSNPDGIHIDAISQRKFGL
                     RYFEAFHKKKHIMEALANESELIIPSNSKTYTKTEKIYINSMDLALGKISYDEFESKL
                     IKLNDN"
     gene            5419..5940
                     /locus_tag="KRO40_003043"
     CDS             5419..5940
                     /locus_tag="KRO40_003043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003442791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093846.1"
                     /translation="MIPLLILGLLKQNPNSYGYELLALMEKKHYKYIVNFTKGSFYYN
                     LQQLEEKKFIEKVENKQSNKNRETHNYIITELGCQEFEKLMYKYGSKTEYINLSFYAT
                     LLFANDYKNEKLIELLETQIKQTQVRISLLNESIENDKTNSHYFNRMLENSRSHHLVN
                     IEWFEKLLNDIRD"
     gene            6291..6824
                     /locus_tag="KRO40_003044"
     CDS             6291..6824
                     /locus_tag="KRO40_003044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor"
                     /protein_id="HBH2093847.1"
                     /translation="MTEVIIVNDARIISQIKAGKKELFDTLIKKYYDSIYCYCYRHVD
                     NKMTAQDLTQDVFVTVINNIENYKHYGKFENYLYVIAKNKCKDFWKKKQPIYLESLDK
                     EISNQELSDIENKMFIKEALTKLPELEFEVIILRYYHDLKFKDIAKIMESSVSVTKYR
                     MSRALKKLELYLEGGKL"
     gene            6821..7582
                     /locus_tag="KRO40_003045"
     CDS             6821..7582
                     /locus_tag="KRO40_003045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093848.1"
                     /translation="MNNKEIKRSLQKYKVPKYDSSALEKTIKTIHELTLSNTYKRMNN
                     KDFFISQIGFIRKRTWIMQFIILCTICIFLFSTSADSNSFYNTLSLISIASPLFVLTN
                     IEELTKVYNSSILEIEFSTKNTLHKIIATRMLIFGISDLLFMIIILVSAKQIIDVNIL
                     YIIIYILVPFNLMCIGCMEIINRNKGKHTNYYCMIYGISLVLLIVTLSNFRDNLYQFE
                     AINQWLIVFLVTAVTLIYEIRKTWRHLCSFENIII"
     gene            7620..8486
                     /locus_tag="KRO40_003046"
     CDS             7620..8486
                     /locus_tag="KRO40_003046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093849.1"
                     /translation="MELSVERLTKQYNNKIIVDKIDFKLNEGIYGFLGENGAGKTTLM
                     RMICGILSPTSGEVKVDGKNNLDMGEDFRDMIGYLPQNFGYYPDFTAKEFMLYIASLK
                     GLMPSYAKRKTQELLEMVGLSEVINKKIRTFSGGMKQRLGFAQTLLNDPKILILDEPT
                     AGLDPKERVKFRNLISEFSKEKIVILSTHIVSDVEYIADKILIMKKGRFVLTGSVEEV
                     TSKIKDKVWKCVVNENEIDYMSDRYCLANIHHSGGVANLRIVSDIKPHDNACNLKPTL
                     EDLYLYCFNEVL"
     gene            8507..9748
                     /locus_tag="KRO40_003047"
     CDS             8507..9748
                     /locus_tag="KRO40_003047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBH2093850.1"
                     /translation="MSTLIKFELKKIIKRKSTIAVILGSLFLSIILFALMPIQEKAND
                     ESGKEYRGLQAIELKKQQSKLNEGYITDKKVKNSIRDYQKMFNNPNNIVTNESGFSDF
                     KPDIYWKFFYPNKTFYNFIIESYSKPNDFNPEVIKSMPLENEINFYKFRNEKVNTILN
                     MEYPEGNYTQKEKDFWLSKNKDIKEPYLNGYYQGWEYFLLARDLLIFTIMAVCISIAS
                     VFSGEYQSGADSVVLTSKYGKTKVITAKIISSFLFGTIIFTINTIVSIGILLLSFGTD
                     GWNLPLQLTTSSIPYPYTFLQAILLSVLTIYMVLIVLISFTLLLSSYMKSPFPVLITN
                     IILLFVPIFFKYSETNKLYNQILNVLPSNAISFSFTNYVDYKFGNLIIALPTMIIFTC
                     LVLTVVFLPFIKNNFKKHQVN"
     gene            complement(9972..10544)
                     /locus_tag="KRO40_003048"
     CDS             complement(9972..10544)
                     /locus_tag="KRO40_003048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2093851.1"
                     /translation="MFKKIVAMASSIIVSTICLTGCDFNSNDKKDESSSSKNLDKVTI
                     AEVTHSVFYAPQYAAITKGFFEDEGIKIDLINTQGADKTMAALISGEANVGLMGPEAS
                     IYVYNQNKNDYAVNFAQLTKRDGSFLVARKKMPNFSYNDLKGTEILGGRKGGVPLMTF
                     EYVLKEKGLTIGENLKAGNVNVRTDVQKSV"
BASE COUNT         3953 a         1375 c         1478 g         3907 t
ORIGIN      
        1 agtattatac ttatatttaa aaataaaaga attttattcc tattgtgtaa agtgagaata
       61 ctattttctt atattggtat aataatagta aatctaatat agaaaagagg tatttctagt
      121 atgcatgaaa ataaaaagaa tctattagac ggaagcttag ctcaatataa tgatacagca
      181 gttccaaaaa taccagtatt tgctggtaac gatataactt cagaagttta ttattttaaa
      241 cctaatcaag ttcttaatgc tcatagacac cctaatggtg aacaaatatt tgtgttccta
      301 aaaggagaag gtaaaatgaa acttggtgag catgaatgtg atgtaaaaaa cggcgatact
      361 gtatttgtac caacaggaga gtggcatgaa attactaatg gaagcaatga agaaatggta
      421 gccgttcaaa ttacaaaaat taatgctgga gcagaataca gaggatagat atataagtac
      481 agttagtact ttaatatcta ttttattata taaactttaa tctcaaatat aaaaagagtc
      541 ttttaaaagg ctctttttat atttttgtta attttcatta taaaaacaag aaaatatcta
      601 gctaaaacta atatatttta tttaatattt tttatagcat tgtttgcaaa ctcagtattt
      661 acgatatctt tataaggtgc ttccttatct agttctttag cttctttcat aacagtcatc
      721 aatttcttca aaccttcctc ttttaataca ggattttgag accatgcatc tattgattta
      781 tatctatcta caactgttgt taaatcttct aaagatatat cttcaaagaa aggttgcata
      841 gccttagcta cttctttgct agatgcttgt tgaatccata attgaccttt ataaacagca
      901 tttgtaaatc tttgaattaa atctttattg tttttcatgt atgatctcgt agtagagtat
      961 gctgtaaaag gtatttctcc agaatctttt cctatagatg tgactatata tccactacct
     1021 tctttttcca ttgctgttgc tgtaggttca aatgctgttg taaagtcacc ctctccacct
     1081 gcaaaagctc cagccattac accaaattgg taatcagtct atttataaca tttaaaacat
     1141 ataattaatc tcttgggata ttagggtaaa gtattaaaga aaaatcatca gatttttgat
     1201 taggttcttt tttatagact gcataattta ttacactttt aagcaatata ttttttagat
     1261 aaggttcttt ttcctctgta tattcactta aaattttttc aagttgagga acaatttgtg
     1321 ttttaactgt atttctttcc ttttgcattt caatatctat atttgtttta ttaatagctt
     1381 ctcttacatt ttctatacga gataagagta tttttaaacg ttccccaaat gtattattgt
     1441 cataaattcc ttgttctaaa aaatcatgta gtcgttcttt ttgtttttct aaagtatcca
     1501 attctttatt taaatttgtc aaggtatgtt ctaaagtatt ttcaggttta gagttatctt
     1561 tttcatcttt taaagatagt ctataattta ctaaccattt atttaagacc tctaatattt
     1621 tattttctaa tatgtatagt ttagtagctt tatttttaca attagtacaa accatatatt
     1681 tctcatatcc atttgatgta gtattagatt tggctattaa agtatgatta cagtatccac
     1741 attttacaat tccagccaat ggatttgtta ttttattgtt tggagtaggg gaattaatac
     1801 gtttttttct tatattttgt gccttattcc atatgtcttc acttattatt ggttcatgct
     1861 ttccttttac ctcaatttgt tcctcaattc ctcttgttct actagaattt cttttcctct
     1921 cgactttatt ccatactata tatccacaat acactttgtt ttttataata tctcttatac
     1981 ccttttcata ccaagttcta cctgttgtgg tcttataacc aagttcgttt aaataattgg
     2041 atattttaca tgcaccatct ccttttaaat acatatcaaa gattatttta acaacagttg
     2101 ctttatcttc atttattaca agtactcttt ctttattatt taaatattta atatcatacc
     2161 cataaggagg agcttgagct ataaatttac cctcttcaat acttttgatt tttcctcttt
     2221 gcatacgtct agatattaat tttaattcct tacgagccat aaaagcttca aattcagaat
     2281 actcctcatc aaactcatca tttaaatcat acgtttttct aggagtaata attttcgttt
     2341 tagatttttt aaatgtatct agtattaacc cttggtcttg catattacca cgacccaaac
     2401 ggtcaatatc catcactaaa acagcatcat agttattatt tttaatttca cctagtaatt
     2461 ctagcatctt aggtctatat tctatacttt ccccagaaac aagttcttct ttaatttcaa
     2521 tgacatttaa attttgttct cttgctagtt ttaaaagagt tgtcttatgt ctacttagag
     2581 tttcaaattc acctctatgt tctgcttctt catcagctct gcttttgcgt aaataaattg
     2641 ccacattcat taaatcacac cccttgaata tattatattc agtaacagat tgattatatt
     2701 taaaacacaa aaataaacct tcaaaataca agatatattt tttaggttta tttttataca
     2761 gtaaatttta tagtatattt aaaagcttgt aatctaagta aatatttata ctattaattt
     2821 tatgctttct tcatttttta attttaaact atttttttac tacaggtatc catacttcaa
     2881 atttagcatt ttgagggtct ggatttaagt acagttcaat atcaggacca ttatcatatt
     2941 cataaccaga agtaggtaac cattctgtta caatacgctt ttctagttct tgtattgctt
     3001 gtggacattg tccttctcca gaaaatattg cccaagtaaa agctggaaca gtgtattctt
     3061 ctaatgtatt atctatagat tttgtacttg aaacagatat aaaatacttc cattcttctg
     3121 aattattaca aatacttata cctaatacac cttgaagttg actatccatc atagggatta
     3181 atttttgaag cgttccatct aaagcaacct tttgccacat ttggggaaca atttcaaaat
     3241 tcttttctag ttcattatga agtggctgag atacaccaac tatacgaaat gcttctttct
     3301 tttcaattct ataattcatt tcttcggctc ctttaatact aattttaaaa ctgattggag
     3361 gaaaggcttt taaagttgtt atttctcttt tttttataac tgatggggca acaccatgaa
     3421 tacttttaaa tgcacggttg aatgctgttg gagaagagta tccatatttt aaagccacat
     3481 caattatctt tttatcatca ttttgtaatt ctacagctgc taaagacatc cgtctacgac
     3541 gaatatattc agaaagtggt acatctgcca tataagcaaa cattctttga aaatgatatg
     3601 tagaacaaca agctattttt gccacttgtt catactcaat ttcttttgtt atgttttctt
     3661 caatatagtt aattgctttg tttaatcttt caatccattc cataaaatca gctccttgta
     3721 atttatataa tatctatttt aaaatagtta atcctctctt tctatgcact aattaactag
     3781 cttaataaag aatgaacatg agaaagtctg taattaacta caaaaatgaa caaatagtat
     3841 tgtttttcac attaaagtat atcacagatt agtatctaat ttttatataa gataacagtt
     3901 ttaatttatt atgaaatttt tataatattt tagcttagac atttaattat atataacatt
     3961 ttattcatag ttaactattt ttgaagttta cccttaatca agcaacactt agttactcaa
     4021 ttataaataa tgattgagaa taggacaatt tttaagatac ataaaatata aagaggaggg
     4081 gatttaaatg ccaaatatag aaaaagactt agatggtaca actactataa catacctcaa
     4141 tgacgatata ggtgttccaa cagacgagaa tggatataaa atatctatga caatactaca
     4201 tggaaagaca atctgccatg tagtatctcc tgaaacaatc ttaggaagaa agttcacatt
     4261 agaagaaaaa caagaaaaag atacaataat atatggagca atagaaaaaa taatggtaga
     4321 cagacaatta caaataaaaa attcaaacaa agaagttgct agtcattagc acttctttaa
     4381 taagtaaagt aggacaagta ttttttataa tattattgac ttatagtcta attagactat
     4441 aatataaaca tagatagtct aattagacta ctattaaaaa taaatacaat aagaatttaa
     4501 gaaaggataa taataataat gattaaatca tttttaatgt taggacagtc caatatggct
     4561 ggaagaggat tcataagtga agtgactcca atttataatg aaagaataca gatgttacgt
     4621 aatggaagat ggcaaatgat gacagaacct attaattatg acagaccagt ttctggggta
     4681 agtcttgctg catcatttgc agatgcatgg tgctgtgaaa atcaagagga tagaattggg
     4741 ctaattcctt gtgctgaggg aggcagttcc ttagatgaat ggaatataga tggtatactt
     4801 tttaaacatg ctataagtga agctaaattt gccatacaaa gcagtgaatt gacaggaatt
     4861 ttatggcatc agggagaaaa tgacagtaat aatggcaact ataaatttta ttataaaaaa
     4921 ttactttcta ttattgaaac tcttagaaaa gaattaaata ttccagatat accaattatt
     4981 attggtggat tgggagactt cttaggaaaa gtaggttttg gaaaaagttg tactgagtat
     5041 gtatttatca atcaagagtt acagaaattt gcttttgaac aagataattg ttactttgtt
     5101 acagcaacag gtcttacatc taatcctgat ggtattcata ttgatgcaat atctcaaaga
     5161 aaatttggat tacgttattt tgaagctttt cataagaaaa agcatattat ggaagcatta
     5221 gctaatgaaa gtgagttgat aataccgagt aattccaaga catatacaaa aacagaaaaa
     5281 atatatataa atagtatgga cttggcacta ggaaagatat catatgatga gtttgaatct
     5341 aaacttatta aacttaatga taattagata aaatattcat taatatacta ataaatatag
     5401 attgaaagag gtgatttttt gataccatta ttaattttag gattattaaa acaaaatcca
     5461 aattcttatg gatatgagtt attagcatta atggaaaaga agcattacaa gtacatagta
     5521 aatttcacta aaggttcttt ttattataat ttacagcaac ttgaagaaaa aaagtttatt
     5581 gaaaaagttg aaaataaaca atctaataaa aacagagaaa ctcataacta cataattact
     5641 gaacttggat gccaggaatt tgaaaaatta atgtataagt atggttctaa aacagagtat
     5701 ataaatctat cattttacgc aacactatta tttgcaaatg attataaaaa tgaaaagtta
     5761 atagaattat tggaaacgca aattaagcaa actcaagtaa gaatttctct attaaatgaa
     5821 tccatagaaa atgacaaaac aaattcacat tattttaata gaatgctaga aaattctcgt
     5881 tctcaccatt tagttaatat tgaatggttt gagaagttgc taaatgatat tagagattga
     5941 ttttaataat aaaaaaacat acatatatac tttatataaa tgtatgatat atagattaaa
     6001 aataaggcag ataattttca attgaatatc tgtctttttg ttatataaga tgttaaaaga
     6061 cacttatact atgtaagtaa aatttataaa tataaagttg ttcattgttg aattacagac
     6121 acttaagatg aaaagtatga catttgatat aataaaattg tttaagtatt aattatgagt
     6181 attaattaat ggtatagata attttaatat aactgtattt ataaataatt ataaaataat
     6241 aaattaattt ttttatactg acttttttat agtataaatc gttatatata atgacggagg
     6301 tgataatagt gaatgatgct cggattatat cacaaataaa agcaggaaaa aaagaattgt
     6361 ttgatactct aataaaaaaa tactatgata gcatctattg ttattgttat cgccatgtag
     6421 acaataaaat gactgcacaa gatttaactc aagatgtatt tgtaacagtt ataaataata
     6481 tagaaaatta taaacattat ggtaagtttg aaaactattt atatgttatt gcaaaaaaca
     6541 agtgtaagga tttttggaag aaaaaacaac cgatatattt agagtcatta gataaggaga
     6601 tatcaaatca agaattgtct gatatagaaa ataaaatgtt tataaaagaa gctttgacta
     6661 aattaccaga attagaattt gaagtgataa ttttacggta ttaccatgat ttaaaattta
     6721 aggatattgc taaaattatg gagtcaagcg tctctgtcac aaagtacagg atgagtaggg
     6781 cattaaaaaa actagaatta tatctggaag gaggtaaatt atgaataata aagaaataaa
     6841 aagaagtcta cagaagtata aggttcccaa atatgattct tcagctcttg aaaagactat
     6901 taaaactata cacgagttaa cgcttagtaa tacttataaa agaatgaata ataaagactt
     6961 ttttatatct caaattggtt ttataagaaa aagaacttgg attatgcaat ttataatact
     7021 atgtacaata tgtatatttt tatttagtac atcagcagat agtaattcat tttataatac
     7081 tttatccttg atttctatag catcaccact ttttgtgctg acaaatatag aagaattaac
     7141 aaaagtatat aatagtagta ttttagagat agaattttca acaaaaaata cattacataa
     7201 aattattgct actagaatgc ttatatttgg aataagtgat ttattgttta tgattattat
     7261 tttggtatct gcaaaacaaa tcattgatgt aaacattctg tatataataa tttatatact
     7321 agttcctttt aacctaatgt gtataggatg tatggaaatt ataaatagaa ataaaggtaa
     7381 gcatacaaat tattattgta tgatatatgg tatatctctt gtattattaa tagttacact
     7441 gagtaacttt agagataatc tatatcaatt tgaagcaata aatcaatggc taattgtttt
     7501 tctagtcaca gcagtaacat taatatatga aataagaaaa acgtggagac atctttgttc
     7561 atttgaaaat attattatct aagtaaaaaa taagaataca cagtatcagg aggaatagta
     7621 tggagttaag tgtagaacgt ttaacaaaac agtataacaa taaaattata gtagataaaa
     7681 ttgactttaa attaaatgag ggtatatatg gatttttagg agaaaatgga gcgggaaaaa
     7741 caactcttat gagaatgatt tgcggaatat taagtcctac atctggagaa gtaaaggtgg
     7801 atggtaaaaa taatttggat atgggagaag attttagaga tatgattgga taccttcctc
     7861 aaaactttgg atactaccca gattttactg ccaaagaatt tatgctatat atagcatcat
     7921 taaaaggatt aatgcctagc tatgcaaaga gaaaaacaca agaattatta gaaatggtag
     7981 gattatcaga ggtaattaat aaaaaaataa gaacattttc tggaggtatg aagcaaaggc
     8041 taggatttgc tcaaacacta cttaatgacc caaaaatttt aatattagat gagccaacag
     8101 cagggctaga ccctaaagaa cgagttaaat ttcgcaacct aatttcagaa ttttctaagg
     8161 aaaagattgt tatattgtct actcatattg tgtctgatgt agagtatatt gcagataaaa
     8221 ttttaataat gaaaaaagga agatttgttt taactggctc agtagaagaa gtaacttcaa
     8281 agataaaaga taaggtatgg aaatgtgtgg tcaatgagaa tgaaatagat tatatgtctg
     8341 atagatattg tttagcaaat atccatcatt ctggtggagt tgcaaatctt agaattgtaa
     8401 gtgatataaa gccacatgac aatgcatgca atttaaaacc aacattagaa gatttatatt
     8461 tatattgttt caacgaagta ctataaatat acataaggag ataggtatgt ctacattaat
     8521 taaatttgag ttaaaaaaaa taataaaaag aaagtctaca atagcagtta ttttaggaag
     8581 tttattctta agcatcattc tttttgcatt aatgccaatt caggaaaaag ctaatgatga
     8641 aagtggaaaa gagtataggg gtttacaggc tattgagcta aaaaagcaac aatctaaatt
     8701 aaatgaggga tacataacag ataaaaaagt aaaaaactca atcagagatt accaaaaaat
     8761 gtttaataat ccaaataaca ttgtaacaaa tgagtctgga ttctcagatt ttaagccaga
     8821 tatttattgg aaattcttct atccaaataa aactttttat aattttataa tagagtcata
     8881 tagtaaacca aatgatttta acccagaagt aattaaatca atgccattag aaaatgaaat
     8941 taatttttat aaatttagaa atgaaaaagt aaatacaata ttaaatatgg aatatccaga
     9001 gggaaattac acacagaaag aaaaggactt ttggttatct aaaaataagg atataaagga
     9061 gccttattta aatggatatt atcaagggtg ggaatatttt ctattggcaa gagatttact
     9121 gatttttact ataatggctg tctgtataag tatagcttct gtattttcag gagaatacca
     9181 atctggtgct gattcagtag tattgacttc taaatatgga aaaacaaaag ttataacagc
     9241 taaaataata agttccttct tatttggtac gattattttt acaataaata caattgtatc
     9301 tattggcata cttcttttat cttttggaac tgatggctgg aatttaccac tacaacttac
     9361 aactagttca attccatacc catatacatt tttacaggca atattactaa gtgtgttaac
     9421 tatctatatg gtattaatag tattaattag ttttacactt ttattatcgt cttatatgaa
     9481 atctcctttt ccagttttaa ttacaaatat aatattgtta tttgtaccaa tatttttcaa
     9541 atacagtgaa acaaataagt tgtataatca aattctcaat gttttaccat caaatgctat
     9601 ttcattttca tttactaatt atgtagatta taaatttggt aatttaataa tagctttacc
     9661 tacaatgatt atttttacat gcttagttct tacagttgtt tttttacctt ttattaaaaa
     9721 taattttaaa aaacatcaag ttaactaaaa tatatattat aaaaagaagg tgtcttaaaa
     9781 tgaacttttt agcttattag gcactcttct ttgtattaat ttaaatatat tttagtatta
     9841 gattaaatat gttttcatca ttttaacaat gaaaaagagc cttatctcta ttttgagata
     9901 gctcttataa agttaaatat taaattgata actataaaat atgtagtttg aatttataat
     9961 ttgtgttata atcatactga tttttgtaca tcagttctta cattaacatt gcctgctttt
    10021 agattttctc caatagtaag acctttttct tttagaacat attcaaaagt cattagtgga
    10081 actccacctt ttctaccacc taatatttcg gttcctttta aatcattgta agagaaatta
    10141 ggcatttttt tcctagcaac tagaaaacta ccatctcttt ttgtcaattg agcaaagttc
    10201 actgcataat cgtttttgtt ttgattatat acatatatag atgcttcagg acccattaaa
    10261 cctacgtttg cttcacctga aatcaaagct gccatagttt tatctgcacc ttgggtattt
    10321 ataaggtcaa tctttatacc ttcatcttca aagaatcctt tcgtaatagc agcatactgt
    10381 ggagcataaa aaacagagtg agtaacttct gctatagtta ctttatccag atttttagac
    10441 gaagaagatt catctttttt gtcattagag ttaaaatcac atccagttag acatattgta
    10501 cttacaatga tagagcttgc cattgcgact atttttttaa acataataaa tacctcccat
    10561 aagacatacg aatagtatat agtattaaaa atttattgta gttgttacaa aaatgtatct
    10621 atgcttataa tatttctaca aaaacttaat aataattttc agttttatgt ttagtttttt
    10681 tagtaatgtg taatattgga taaattatat tga
//
LOCUS       DAEQCW010000118        10538 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.119, whole genome shotgun sequence.
ACCESSION   DAEQCW010000118 DAEQCW010000000
VERSION     DAEQCW010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10538)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10538)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10538
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.119"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(228..1172)
                     /locus_tag="KRO40_003049"
     CDS             complement(228..1172)
                     /locus_tag="KRO40_003049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBH2093852.1"
                     /translation="MQKNKKEGALLKKYFGEIGLIFIAIIWGSGFVATQFALDGGLTP
                     LQIITLRFFLAAIIMNLLFFKQIRANMGKKLLKAGGILGIFLFLAFTVQTIGLMYTTP
                     SKNAFITAANVVIVPFIGFILYRRKLDKIGIISSLVALIGIGILSLEADFSINFGDFL
                     TLICSFGFAFHIFFTSEFAKDNNPMALTAIQFTVAFLMSVVVQTFAGQLKMEAELSGY
                     MGTMYLAVFSTTIGFLFQTICQKRVDGTRTAIILSTEAVFGTIFSIIILKELITAKLV
                     IGSILIFVAIITAETKLSFLKSKKVKLKDSEESSLESI"
     gene            1558..2439
                     /locus_tag="KRO40_003050"
     CDS             1558..2439
                     /locus_tag="KRO40_003050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBH2093853.1"
                     /translation="MVKKRKKKTVALTILVVIVIGIFSMAWADMSRKKEMKETQERLK
                     AERLEKERIEKEKNEPIIGAKKEAVKEYGYDAKIVWDKLNKYDYSNNGEKIVFLTFDD
                     GPSTTNTPQVLDILKRHGVRGTFFIKGDSLERKGANEILKRTFDEGNAIAHHSYTHDY
                     KKLYPNRSLNLDTFVNELNKTDEAMKKVLGKNFSSNVVRCPGGYMSWKNMEPLGNYLK
                     EKNMASIDWNALNADAEGKKKNAQELFEHAKKSSEGKEMVVLLMHDTYGKQETVNALD
                     QIITYFKDNGYQFKILI"
     gene            complement(2500..3708)
                     /locus_tag="KRO40_003051"
     CDS             complement(2500..3708)
                     /locus_tag="KRO40_003051"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HBH2093854.1"
                     /translation="MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGL
                     DPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVL
                     ANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
                     EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIM
                     MPLIEGLDGKEKMSKSLGNYIGIDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVN
                     KIESQLKEGSVNPRDIKMDLAREIVTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQ
                     VKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGK
                     KKFVKIELVK"
     misc_binding    complement(3781..4033)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(4185..5174)
                     /locus_tag="KRO40_003052"
     CDS             complement(4185..5174)
                     /locus_tag="KRO40_003052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2232 domain-containing protein"
                     /protein_id="HBH2093855.1"
                     /translation="MIYGGSVLNTTKKLTEAALLSSLFIVVTIIAVSTGFGYAIYLDF
                     IVPVFFCIICLKCDLKYTILSGITSLLIISLVLGNLGTAIWASQSVLLGIMCGYLINK
                     PTMVMDDLVYGSVFGVIVMVFIDIYASTLIGYSFMKEFQGYSKWIYFNGYTNFIYYLM
                     IALFPFGMVFCIYLLSLILGNKLHILDSNSLKKFLIFKNFRNLNQFLCCSKKAFYICV
                     SYLAIFEVLKLLNVKVDSVYLKTIFISITYISVYFIIRDSCMSLQNFIIAKFRKLLYA
                     RILFLIIILLLFFIFDVTVIGLIIINAFLNKKINIRLSQSNIVNKQINLLIEK"
     gene            5326..5766
                     /locus_tag="KRO40_003053"
     CDS             5326..5766
                     /locus_tag="KRO40_003053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093856.1"
                     /translation="MFKIKHFNDLSLDEFYEIAKSRYEVFACEQKIFSLNDYDDIDKS
                     SYHIFLKENGLICAYARIIPKEYSSYNDVSIGRVLVLSSHRRKGLAKQMMDCAIDFIK
                     VNLHENNITLSAQTYIKNLYLSCGFKEISEVYDEAGIEHIKMRL"
     gene            6093..6320
                     /locus_tag="KRO40_003054"
     CDS             6093..6320
                     /locus_tag="KRO40_003054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBH2093857.1"
                     /translation="MKNLNDIQVKKTVKVEDILSSGNLRERMLALGLTRGAVIDVVRK
                     GPKNNLTVYKIRGSKIALRQEESSLILVSDI"
     gene            6346..8466
                     /gene="feoB"
                     /locus_tag="KRO40_003055"
     CDS             6346..8466
                     /gene="feoB"
                     /locus_tag="KRO40_003055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBH2093858.1"
                     /translation="MGLTHNSTKMSSLKDMFDIDNKEDQFVIALAGNPNTGKSTVFNH
                     LTGLRQHTGNWPGKTVATARGNFKYKNTEYALIDLPGTYSLFALSQEEIVARDFICFG
                     NPDAVIVVCDATCLERNLNLVFQVMELTDKVILCINLIDEARKKGITIDKKLLEDSLG
                     IPVILTAARNGSGMDELLDTLNDVSFDKYKLNNKPVRYNENIENVVKSIQPELDNIIP
                     GINSRWLGLRLIDGDESIFESMSNYIDKDSIDAINEVKKKIPDNINKQKIRDEFTKIN
                     YDYAKKLSDECCSNVAKKSTDREEKVDKILTSKIFGLPIMLLLLGTILWITIEGANYP
                     STLLSNLLLGFEPSISGILNSINCPSWLNDMLVLGLYRTLAWVISVMLPPMAIFFPLF
                     TLLEDFGYLPRVAFNLDHLFKKACAHGKQCLTMCMGFGCNAAGVIGCRIIDSPRERLI
                     AILTNNFVPCNGRFPTLIAISTIFFSSVITNSFVSSVATALCITLLIILGVIITLLVS
                     YTLSKTLLKGVPSTFTLELPPYRVPQIGRTLYTSIIDRTIFVLGRAVMVAIPAGVITW
                     IFANIYIGDLSILSHVANFLDPLAKLIGLDGFILLAFILGFPANEIVVPILLMAYLAT
                     GSMIELDSFSALGQVLREHGWTYLTALNVMLFSLLHWPCATTLLTIKKETGSLKWTAL
                     GFLMPTILAFVVCFLTTTVYNLFI"
     gene            complement(8599..9417)
                     /locus_tag="KRO40_003056"
     CDS             complement(8599..9417)
                     /locus_tag="KRO40_003056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2093859.1"
                     /translation="MEKQYFTTGEFAKLCGISKQTLIFYDKIGIFSPEYKDKNNYRYY
                     SVYQYDTLDILQSLREIGMSLEEIKEYIQNRTPQLCVKMLKEEEKKIREKIKKLRKIS
                     SKMQNRINITVEGISKMNSEEIYISKKFEEYLVLSSDLSNMSNSDFMMELIDFTNYCK
                     SKNLYQGYELGVIVSNENIKNGDYLSISSFYLKIDKKIKDKKLYVKPEGMYACIKHIG
                     KYEDSYKSYEKLKKYIYENEYKIVGNSYEESILDFFCESNEDNYMTEISIQVSR"
BASE COUNT         3792 a         1507 c         1324 g         3915 t
ORIGIN      
        1 ttcataatta atttcctccc aattttatat aattaaattt ttatttttaa gtttaataac
       61 ttgctacaag aatatatata ccccagactt tatagcttaa acactaaaaa taaaatttat
      121 ttcctaatta attttatcac tttgaaacac cagtatcaac caagttttga tgtcaaattt
      181 ctacataata cataatttat ttgattaatt aggaaatagt tgtcatatta aatactttct
      241 aatgaagact cctctgaatc tttaagtttc acttttttgc tctttaaaaa agataattta
      301 gtttctgcag ttatgattgc aacaaatatc aagatactac caataaccaa ttttgctgta
      361 ataagttcct ttagaattat tatagaaaat attgtaccaa atacagcctc tgtggataat
      421 attatagctg ttctagttcc atcaactctt ttttgacata tagtctgaaa taaaaatcca
      481 attgtagtac taaatacagc tagatacata gttcccatgt aaccagataa ttcagcttcc
      541 atctttaatt gacctgcaaa tgtttgaact acaacagaca ttaaaaacgc tactgtaaat
      601 tgaatagctg tcaatgccat tgggttgtta tcttttgcaa actcacttgt aaagaatata
      661 tgaaatgcaa atccgaatga acatataagt gttagaaaat ctccaaaatt aatagagaaa
      721 tcagcttcta aagaaagtat cccaattcct ataagagcta ccaaactact tattattcct
      781 attttatcaa gttttcttct ataaagtata aatcctatga atggaactat tacaacatta
      841 gctgctgtta taaacgcatt tttagatggt gtagtgtaca taagtccaat agtttgtact
      901 gtgaatgcta gaaataaaaa tattcctaaa atccctcctg cttttaataa ttttttaccc
      961 atattggcac gaatctgttt aaaaaacagt aaattcataa ttatagctgc caagaaaaat
     1021 cttaaagtta tgatttgtag aggtgtaagc ccaccgtcta atgcaaattg ggttgctaca
     1081 aagccacttc cccatataat tgctataaat attagtccta tttctccaaa gtattttttc
     1141 aataaagccc cctccttttt atttttttgc aaaattataa accccctaaa cagcaagaga
     1201 gtttttctat aagcattact ataaattaat atagtaaatt ttttcagtat tttaaatcta
     1261 aatttacata cattttgagc tcaaatttat atccactatt taacagtaat atattaatca
     1321 ttttttgtaa acaccttttt aataaatttt tatatttttt atattttttt acctatacta
     1381 aattttttta tagatatttt taatatatat gatactttaa tattatgcaa ataatgtcat
     1441 ataagttaca ctttagttat cttagttaca actttgtcgg tttacttttt ctactttctt
     1501 cgatataatt ataatatatt tttgatacaa ttcgacaaaa gggggaatgc tgtaattatg
     1561 gtaaaaaaaa gaaaaaagaa aactgttgca cttactatac ttgttgtaat agttattggt
     1621 attttttcta tggcatgggc ggacatgtct agaaaaaaag aaatgaaaga aactcaagaa
     1681 agacttaaag ctgaaagatt agaaaaagaa agaattgaaa aagaaaaaaa tgaacctatt
     1741 attggtgcaa aaaaagaagc tgtaaaagaa tatggatatg acgcaaaaat agtttgggac
     1801 aaacttaaca aatacgacta ttcaaacaat ggagaaaaga tagtctttct tacatttgat
     1861 gatggaccat ctactactaa tactccacaa gttctagata tcttgaaaag acatggtgtt
     1921 agaggaactt tctttattaa gggtgattct cttgaaagaa aaggagctaa tgaaatttta
     1981 aaaagaacat ttgacgaagg aaatgcaata gcccatcact cttatactca tgactataaa
     2041 aaactatatc ctaacagaag cctaaatctc gatacattcg taaatgaact taacaaaact
     2101 gatgaagcta tgaaaaaagt cttaggaaag aatttttcct caaatgtagt tagatgccca
     2161 ggcgggtata tgtcatggaa aaatatggaa cctctaggaa actacttaaa agagaaaaac
     2221 atggcatcaa ttgattggaa cgctttaaat gctgatgcag aaggtaaaaa gaaaaatgca
     2281 caagaattat ttgaacatgc aaagaaatct tctgaaggca aagaaatggt tgttctttta
     2341 atgcatgata cttatggaaa acaagaaaca gtaaatgcat tggaccaaat tataacatat
     2401 tttaaagaca atggttatca atttaaaatt ttaatataat aaaaaagcaa gtttattgaa
     2461 tgtacatttt atactcaata gacttgcttt tactttactc tattttacta gctcgatttt
     2521 tacaaatttt ttctttccta tttgaacaac taattcactc tcttttacaa tagtgcttaa
     2581 atcctctact ttttcaccat ttacctttac tccaccttga gaagctaatc ttctaacttc
     2641 actcttactc ttaacaatct cattagaaac tagtacttcg attaagtcaa atccatcttc
     2701 cttaacttga attgtttgta tatcttcagg tatttgacct ttttggaata cagatttaaa
     2761 tctttcttca gcttctttag cagattcttc tccatggtat aatgttacta tttctcttgc
     2821 taagtccatc tttatatctc ttggatttac tgaaccctct ttcaactgag attctatttt
     2881 attaacttca tcaggatgaa catctgtcac taaattgtag tatttaatta taagttcatc
     2941 aggaatttcc atagattttt ggtacattat tcccgcttct tcatctattc caatatagtt
     3001 acctaaactc ttactcattt tttctttacc atctaatcct tctattaaag gcatcattat
     3061 tactatttga gactccatac caaattctct ttgtaatgat cttcccatta gtaaattgaa
     3121 tctttggtca gttccaccaa gttctatatc agcttctaat gctatagagt catatgcttg
     3181 cattaatggg tagaagaact catgtactga tattggcatt tgtccttcat atctcttttt
     3241 aaaatcttct ctttctaaca ttctcgcaac agtaatagtt gctgctaatt ttattacatc
     3301 ttcaaaattt aacttagcta accactcgct attaaatctt acaatagttt tttctttatc
     3361 taaaactttg aaaatttgtt cttcataagt ttttgcattt gcaagaactt gctctgttgt
     3421 taaagctttt ctagctttag attttccagt tgggtctcca atttttcctg taaaatctcc
     3481 aattattatt actatttgat gacctaaatc ttgtaattgt ttcatctttc taagaactac
     3541 tgtatgccct aaatgtatat ctggagcact tgggtctaga cccaatttta ctatcatagg
     3601 ttttccttct ttttctgatt taataagctt ttcccttaac tctttctcat ctattaaatc
     3661 atctacacct ttcataatta ttcgcatttg ctcgtctatc gatttcattt ttcattcctc
     3721 ctaaaatatt tatataatct ataattttta tttttataat aaaaaaagct ttcatcctct
     3781 taaaaggacg aaagcattgc ttacgtgtta ccaccttagt tcatcaatat ctcacgatat
     3841 taatctctta gagtacaatt acatatactc gtgtactata acgtgtacta atccgatatc
     3901 tcttaatggt tgttatcttt cagagatagt gctctgagat gtattcaaac taaatcaatt
     3961 tattccattt caccaaactg gaactctctg ttaaataaaa tctagcccta cttcttctct
     4021 tcatagcatt tatatattca gattatttca tcaattacaa gaaatttttc ttaacttact
     4081 cataatatat tattattttt atattttgtc aacctttttt attattatat acatgttttt
     4141 ttacattata ctactttttt atatttttta ccaataccca aaatttattt ttcaatcaaa
     4201 agatttattt gtttattgac tatattactc tgactcaatc ttatatttat tttcttattt
     4261 aaaaatgcgt ttataattat taaaccaata actgttacat caaatataaa aaacagcaat
     4321 aaaattatta tcaaaaataa aattctagca tataataatt ttctaaactt agctattata
     4381 aagttttgta gtgacataca tgagtctcta atgataaaat agacacttat ataggttatt
     4441 gatataaaga ttgtttttaa ataaacagaa tcaactttaa cattcaacag ttttagaact
     4501 tcaaaaatgg ctagataaga aacacatatg taaaaagctt tttttgagca acataaaaat
     4561 tggtttaaat ttctaaaatt cttaaatatt aaaaattttt ttaaagaatt agaatctaaa
     4621 atatgcaatt tattccctaa aattaaactt aataaatata tgcaaaacac cataccaaaa
     4681 ggaaacaatg ctatcattaa ataataaata aaatttgtat acccattaaa ataaatccat
     4741 ttgctatatc cttgaaattc tttcataaaa ctataaccta ttaatgttga agcatatata
     4801 tcaatgaaaa ccattacaat aaccccaaat actgaaccat atactaaatc atccataacc
     4861 attgtaggct tatttattag atagccacac attataccaa gtaatacact ctgacttgcc
     4921 caaatagcag ttcctaaatt tccaagtacc agagaaatta ttaaaagcga agtaattcca
     4981 gataaaatgg tatactttaa atcacatttc aagcagatta tacaaaaaaa tactggcact
     5041 ataaaatcta agtaaatagc atatccaaat ccagtactca cagctataat tgttactact
     5101 atgaataaag atgacaataa agctgcttca gttaattttt tagtagtatt caaaacactg
     5161 cctccataaa tcataaattt tctaactaaa gttttgtttt taatatagta tatcactttt
     5221 taaaaatatt tttaataaat ataaatttta ataaaggtat ttatgttaaa aatggtataa
     5281 tgtatcttaa tattcagttt tttaagatgc taggaggtaa ttactatgtt taaaattaaa
     5341 cactttaatg atttgagttt agatgaattt tatgaaatag caaaatcaag atatgaggta
     5401 tttgcttgtg aacagaagat attttcatta aacgattatg atgatataga taaaagctct
     5461 tatcacatat ttttaaaaga aaatggattg atttgtgctt acgctagaat aattcctaaa
     5521 gaatacagct cttataatga tgtttccatt ggtagagttt tagttctttc tagtcataga
     5581 agaaaaggat tagcaaaaca aatgatggat tgtgctatag attttataaa agttaactta
     5641 cacgaaaata atataacctt atcagcacaa acttatataa agaaccttta cttatcttgt
     5701 ggttttaaag aaatctcaga agtatacgac gaagcaggta ttgaacatat taaaatgaga
     5761 ttatagtgtt gacaagctaa tattgttaat atataattta agtataaatt aaatattgaa
     5821 ttgatattta ggtatttgaa aataccttac atagagtcag aaggcttttg ctttctgact
     5881 tttttattat caaaattcaa taattatatg gattcaaagt gttaattttt attctatatt
     5941 ctactttccc caaaagtaag aattataccc aactttgtat gataggcatc ttgcctatct
     6001 tttttttgta aaagtaacaa ggtaataata taatgcatag tttaaaataa gaagattagc
     6061 ccaggctaaa tttcaagcat ggaggtgcta ttatgaaaaa ccttaacgat attcaagtga
     6121 aaaaaactgt caaagttgaa gatatattat ctagtggtaa tttaagagaa agaatgttag
     6181 cgcttggtct tactagagga gctgttatag atgtagttag aaaaggtcca aaaaataatt
     6241 taactgtcta taaaatcaga ggtagcaaga tagctctacg acaagaagaa agtagcttaa
     6301 tattagtttc tgacatttaa aaatttctag caggaggata ttaatatggg gttgacacat
     6361 aactcaacta aaatgagttc tttaaaagac atgtttgata tagacaataa ggaagaccag
     6421 tttgtaattg cattggctgg caatccaaat acaggtaaaa gtactgtatt taatcatctt
     6481 acagggctta gacagcatac tggaaactgg ccaggaaaaa ctgtagctac agctcgtggt
     6541 aattttaaat ataaaaatac cgaatatgca ttaatagatt taccaggaac atattcttta
     6601 tttgccttat cacaagaaga aattgtagct cgtgatttta tatgttttgg taatccagat
     6661 gcagtaatag tagtatgtga tgctacatgt cttgaaagaa atttaaattt agtatttcaa
     6721 gtgatggaac ttacagataa agttattttg tgtattaatt taatagatga agctagaaaa
     6781 aaaggcatta ctattgataa aaaactttta gaggattctc ttggtattcc agttatttta
     6841 actgctgcaa gaaatggctc tggtatggat gaactattgg atactttaaa tgatgtatct
     6901 tttgacaaat ataaattaaa taataaacct gttagataca atgaaaatat agagaatgtg
     6961 gtaaaatcaa ttcaaccaga attggataat attataccag gtataaattc tagatggttg
     7021 ggacttagac ttattgatgg cgatgaaagt atatttgaat ctatgagtaa ttatatagac
     7081 aaagattcta tagatgctat taatgaagta aagaaaaaga ttccagacaa tataaataaa
     7141 cagaaaataa gagatgagtt tactaaaatc aactatgatt atgctaaaaa actgagtgat
     7201 gagtgttgtt ctaatgttgc taaaaaatca actgatagag aagaaaaagt agataaaata
     7261 ttaacatcta aaatatttgg gcttccaata atgctcttat tattaggtac tatattgtgg
     7321 attactatag aaggagctaa ctatccatcc actttattat ctaatttatt actcggattt
     7381 gagccaagta tttcgggtat attaaatagt attaattgtc catcatggtt aaatgatatg
     7441 ttggttttag gattatacag aacattagca tgggtaatct ctgtaatgct acctcctatg
     7501 gcaatatttt ttccattatt taccctactt gaggattttg gatatttgcc aagagttgca
     7561 tttaacttag accacctatt taaaaaagct tgtgcacatg gaaaacagtg tttgactatg
     7621 tgtatgggat ttggatgtaa tgcagctgga gttattggtt gtaggataat tgactctcca
     7681 agggaaagac ttatagctat acttacaaac aactttgttc cttgtaatgg tcgttttcct
     7741 actttgatag ctatatctac aatatttttt agctcagtta taaccaactc tttcgtatca
     7801 agtgtagcaa ctgcactttg cataacttta ctgataattc taggtgttat aataacattg
     7861 ttggtttctt atactctttc taaaacgcta ttaaaaggag ttccgtctac atttacatta
     7921 gaacttcctc cttatagagt tcctcaaata ggaagaactt tatatacctc tataatagat
     7981 agaacaatat ttgttttagg aagggctgta atggtagcca tacctgctgg tgtcataact
     8041 tggatatttg caaatatata tataggagat ttaagtatat tatcacatgt tgcaaacttt
     8101 ttagaccctt tagctaaatt aattggtctt gatggtttta tattacttgc ttttattctt
     8161 ggattcccag caaatgagat agttgtacct atacttttaa tggcttacct agcaactggt
     8221 tctatgatag aattagatag ctttagtgct ttaggtcaag ttcttagaga acatggatgg
     8281 acttatttga cagctttaaa tgttatgctg ttcagtttac tgcattggcc ttgtgcaaca
     8341 acacttttaa caataaaaaa agaaactggt agtttaaaat ggactgcctt aggattctta
     8401 atgcctacta tacttgcttt tgttgtttgt tttttaacaa ctacagttta caatttattt
     8461 atataattag tattaactga cagtagacat atattagaga aactatttaa aaatttatat
     8521 actttattat aaagcataga gatatattca atgataagta aaattactta acatttgaat
     8581 atatctctat tttaattctt atctggatac ttggattgaa atttcagtca tataattatc
     8641 ttcattactt tcacaaaaaa agtcaagtat actctcctca tacgaatttc caacaatttt
     8701 atattcattt tcatatatat attttttcaa tttttcgtaa gatttatatg aatcctcata
     8761 ttttccaata tgttttatgc aagcatacat tccttctggc tttacatata gctttttatc
     8821 ctttattttt ttatctatct tcaaataaaa acttgatata cttaaatagt ccccattttt
     8881 tatattttca ttacttacta ttactcccaa ctcatatcct tgatacaaat ttttagattt
     8941 acaataattg gtgaaatcta ttaattccat cataaaatca ctattactca tattactcaa
     9001 atcgcttgat agaactaaat attcttcaaa ctttttggat atataaattt cttcactatt
     9061 cattttagaa attccttcaa ctgttatatt tattctattt tgcatcttag aacttatctt
     9121 tcttagtttt tttatttttt ctcttatctt tttttcttct tctttaagca ttttcacaca
     9181 aagctgggga gttctatttt gtatatactc ttttatttcc tctaaactca ttcctatttc
     9241 tctcaatgat tgtaatatat caagtgtatc atattgataa actgagtaat atctataatt
     9301 atttttatct ttatattcag gagaaaaaat acctattttg tcatagaaaa tcaatgtctg
     9361 cttagatata ccacacaatt tagcaaattc acctgttgta aaatactgtt tttccaaggg
     9421 ttatacactc cttttctttt tgttgtctat atagttacta tattctttat tatttactaa
     9481 atcaagtagt tattatttta gaaaatcaat atgattttga ttttaaagct taaatatcag
     9541 ttagatgtca gttataaata ttttatccat tcccatcata aaaaagatat cccctcttaa
     9601 cttttggatg gaatattata tttatacttg ttagagtgaa aattgtaata ggtgctacaa
     9661 taagatattt aattaaacat aaagttaatt attgtaataa aaaatcttta gataaattag
     9721 agttaaagta tggaaatata gatagagaaa aagctgttaa actagaaata ttttattaat
     9781 atttaataga acttgaatat atagaaatga gtttattaat aagaagatta gatactgcaa
     9841 taacatcatt agcattagta tctattataa caatagcatc atattattta atcagaaaaa
     9901 atgtgtaatt atgtaagcta tttataataa aacactgata aaattaataa taaaaaggta
     9961 ataggatttc tatactacct tttggttttt ataatatagt gtaattttat tatatttttg
    10021 tatgctaata taactagata atcataagat aacacattaa aagaaaatta taaaaactta
    10081 cattctgtat agttaatata aaacataagt aatataaatt tatgtaaagc aacaaaagat
    10141 ggatttacat tccatatagt taatataaaa cgatttcaaa tgattagaat aaaaatatca
    10201 gaattgctat ttatattcca tatagttaat ataaaactca aacatatcta agttgtattt
    10261 ctcaccttgt aggtcattta cattccatat agttaatata aaacaaggat tttgaatgta
    10321 atttatcata agggtggcag atttacattc catatagtta atataaaaca tgaaagataa
    10381 ttggaaaact aaagtgcaat ctaaaaaatt tacattccat atagttaata taaaacggag
    10441 aattattaaa aggagttccc gaagcagata gaataattta cattccatat agttaatata
    10501 aaaccattgt tattattgtg gttctccctt agctcata
//
LOCUS       DAEQCW010000119        10471 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.120, whole genome shotgun sequence.
ACCESSION   DAEQCW010000119 DAEQCW010000000
VERSION     DAEQCW010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10471)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10471)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10471
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.120"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(169..738)
                     /locus_tag="KRO40_003057"
     CDS             complement(169..738)
                     /locus_tag="KRO40_003057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBH2093860.1"
                     /translation="MIIIYGYCRVSTKNQTDNNSLYQQQQEILNKYNDAKIIKETYTG
                     TTTNRPKFEKIISSLKKGDLLVATKLDRLARSTSEGIQLIEGLFAKEVSVHILNIGLL
                     ENTSMGKFFLTTLLAVAELERNMIIERTQLGKEFAKKKKDFKDGRPKKYSNQQIQYAL
                     GLLNSKPYREVVKMTGISKSTLIRAKKSI"
     gene            941..1168
                     /locus_tag="KRO40_003058"
     CDS             941..1168
                     /locus_tag="KRO40_003058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBH2093861.1"
                     /translation="MNSLLKEAIDELKNIHCGEVFLLKELFKGYEWNRLEMNIRLKLG
                     KLFLYEVVTNPNLNVEVINKNSAYQQMYKKK"
     gene            complement(1387..2130)
                     /locus_tag="KRO40_003059"
     CDS             complement(1387..2130)
                     /locus_tag="KRO40_003059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBH2093862.1"
                     /translation="MENYQSTNTCTYNILYVQFNEDFERSKYFSYDVKYPVIYNIRNQ
                     STYVNPVILNNINNAVRMTVNNFKNGLQEEEREYNNATSQNSLPKQSYWVSTSYAVTF
                     NKNYVLSMILNLMGFANNYGPKYNTLNNYNIDLTTGKELLLNDIFRDGVDYINIITDY
                     IKSQINENREMYYSNVELVIPEDQAFYLTDNGIIIYFGVDEIAPESFGIPKFELKFSD
                     FGNFINLRFYCISPDIYVQSRGRAKHFMG"
     gene            2298..3170
                     /locus_tag="KRO40_003060"
     CDS             2298..3170
                     /locus_tag="KRO40_003060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2093863.1"
                     /translation="MLLLADKWKDYELIDMGNGEKLERWGSYVLRRPDPQVVWPMESE
                     WALWKNPHGHYHRSNKGGGQWEHKKRYPEQWTINYKNLKFHIKPTGFKHTGLFPEQAA
                     NWDWMIEKIKKANRPIKVLNLFAYTGGATVACASAGAEVCHVDAAKGMVNWAKENIEL
                     SGLKNQTVRFIVDDVVKFVEREIRRGKKYDAIIMDPPSYGRGPKGEVWQIEEKLYSFV
                     DLCMGVLSDNPLFFLINSYTTGFSPIVLENVLSTTIGKKTNTGDIYGGELGIPASRDG
                     KILPCGIFGRWEKK"
     gene            3170..3835
                     /locus_tag="KRO40_003061"
     CDS             3170..3835
                     /locus_tag="KRO40_003061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBH2093864.1"
                     /translation="MIKVIYEDNHLLVVEKPVNILSQGDNTNDKDMVNLLKDYIKKKY
                     NKPGNVYIGLIHRLDRPVGGVMVFAKTSKAASRLSEQVRSKTFKKTYLAVVHGKIKSN
                     SDILKDFLYKNKKTNMVTVVKKSHKDAKEAELNYNVLDFKENLSLVQVNLKTGRSHQI
                     RVQFASRKHPLYGDQRYGKEINKIGQQISLWSNKIEICHPTTKEKMEFTCHPPDKYPW
                     NIF"
     gene            3856..4713
                     /locus_tag="KRO40_003062"
     CDS             3856..4713
                     /locus_tag="KRO40_003062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2093865.1"
                     /translation="MSKKFSIGEMSKLHKISIQTLRYYDQIDLFKPVHVDQESNYRYY
                     SIDQFSQLDIIKYLKYLGMPLKEIKSKLDENNEEILKLLTNKINIVDEKIKELELIKK
                     VLSTKKETMEKGMKVDEVGKIVRKHIPRRSILSIEYEEGLSSEETMELSRRQIANILE
                     DNISVFYGGVSGLVSIDKFLKEDKVIYDNSFVTVERDLFDIKSQKHITEISSGDFICM
                     TYKGPYKENYTAFKKLVDYVEYKRIPIENYIYEIPIIDPLSTNNEEELLTEIQIQVKK
                     REIDLRCLV"
     gene            complement(4869..7415)
                     /locus_tag="KRO40_003063"
     CDS             complement(4869..7415)
                     /locus_tag="KRO40_003063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2093866.1"
                     /translation="MNIFNKVALQGLKKNRTRTLVTIIGVVLSAAMITAVTTFGVSLM
                     NYMTNGAIIKYGDWHVQFLDVDSSFVQEQRVNDEVANTATFENIGYATLEGNRNPDKP
                     YLFIAGFSKEAFDTLPITLISGRLPENSREILVSSKVATDGGVKFAVGDTISLDVGKR
                     MSENEKLGQSDPYTAGSEVFVPQDKKTYTVVGICRKPVFEESSAPGYTLITKEDKQVK
                     TDSLSLFVTLKNPHQIRSYISSTKDHASIFNDNVLRFIGVSDNNLFNMFLYSVGGIVL
                     AIIMLGSIFLIYNSFNMSLNERTHQFGILSSVGATAKQLRNSVLFEGICIGAIGIPIG
                     VAIGIVSIGLVISVIAKNFANILYVNVPLTLTLSIPAIIVAAVVSMVTILISAYIPAR
                     KAANTPVMECIRQTNEVKIESKSVKTSKLTQRVYGLEGVLAMKNFKRNKKRYRSIVLS
                     LVLSIVLFISTSALVADLKQMSNQRSEVTDQDIIFSTQGMKDNEMLKLYDKLKTANGV
                     YEGLYQKLMTYSCVAKVSELTDDYLNYEGSHSMSEMLELPVDMQFLDDRTYLNIIKSL
                     GLPAEEYTGQNAKLIAVSMVTKDNNIIDIFNSSSMNVSLTPETNGKLEIPERQNVNIS
                     FVKVVPPDSPPGIRSSDVKKASFRVLAPYSAKDKFEIPGVSTGIESLSFQSKNPTQSV
                     AEMEQIIESEGVTNEYNLYNMYGMMDENRNYIFIANVFAYTFIIMISLISIANVFNTI
                     STNIKLRRRELAMLRSVGMSEHDFQKMMNFECAFYGMRALFFGLPIAVISSWLIHKVM
                     VTDDIDFVIPWFSIGISIFSVLFIVFITMLYTINKIKKENIIDALRDDMA"
     gene            complement(7415..8101)
                     /locus_tag="KRO40_003064"
     CDS             complement(7415..8101)
                     /locus_tag="KRO40_003064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093867.1"
                     /translation="MAFLKIEDLCKVYGKNENKVTALDHVSLTIEKGEFTAIIGSSGS
                     GKSTLLHSIAGVDVPTSGKIYLEGQDVYGQSNEKLAIFRRRQVGLIYQFHNLIPTLNV
                     VENITLPILMDKRKVNQERLNDLLELLGLKERKTHLPNQLSGGQQQRVAIGRALMNAP
                     AVMLADEPTGSLDSKNGQEIIQLLKESHSKYHQTLIIVTHDENIALQADRIICISDGK
                     VVRDERKVNR"
     gene            complement(8184..9173)
                     /locus_tag="KRO40_003065"
     CDS             complement(8184..9173)
                     /locus_tag="KRO40_003065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2093868.1"
                     /translation="MFRNREFRKFAILFLLITILTVALGFAISIMTGILSIVSATTFG
                     IAFFVFTKNRYKSIAQISEQINLVLHNANHLYIAESDEGELSILQSEITKMTLRIREQ
                     NYALKKEKEHLADSLADIAHQLRTPLTSVTLILSLLENTSDEDERKELIRETEELLIR
                     MDWLITSLLKLSRLDAGIVVFQKEQIDVNNLISSALHQLLIPMELHNITLHIDIPKGV
                     RILGDLNWLSEAIQNIFKNCMESVGDNGKIDIICEDNFLFTQLTIHDNGAGFKKEDLP
                     CLFNRFYRGKNSSTAGYGIGLALCKTIIMRQGGTITAQNHPQGGAIFVIRFPK"
     gene            complement(9160..9846)
                     /locus_tag="KRO40_003066"
     CDS             complement(9160..9846)
                     /locus_tag="KRO40_003066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093869.1"
                     /translation="MKRIFLVEDDKAIAKNLILLLNSEGFIVTHVSTRSEALVEIAKN
                     KFDLALIDISLPDGNGFTICTEIKEKQDIPVIFLTASGDESSVVTGLNMGADDYITKP
                     FRPRELIARIRTALRKSGRFGSTFEICGLYVDTATGVVKKNGNEVFLSALEYRLLLVF
                     ISNPKSIITRVRLLDELWDAAGEFVNDNTLTVYIKRLREKIEDDPSSPQIILTVRGTG
                     YRLGGSYVSK"
BASE COUNT         3712 a         1727 c         1532 g         3500 t
ORIGIN      
        1 tacctaacat ctacaataaa atatactctt aaaataaaat tatataatta aaaatactct
       61 ataaaagcta aaaagttttt ctattcgcta catctaaaaa taattagata gaggtataaa
      121 tgtatttagt ttatttatac ctctagtctt ttataaatta tatctctact aaattgattt
      181 tttagcacga ataagtgtgc tcttggagat accagtcatc ttcacaacct ctctatatgg
      241 cttagaattt aataacccca atgcatattg tatctgttga ttgctgtatt tctttggcct
      301 accatcttta aagtcctttt tctttttagc aaattctttt cctaattgag tacgttctat
      361 tatcatattt ctctcaagtt ctgcaactgc aagtaatgta gtcaaaaaga atttacccat
      421 tgaagtattt tctaaaaggc ctatatttaa aatatgaaca cttacttctt tagcaaataa
      481 accttctatt agttgtattc cttctgatgt acttctagct agtctatcca gcttagttgc
      541 aacaagtaag tctccctttt ttagagatga tataattttt tcaaatttag gcctgtttgt
      601 agtagtgcct gtataagttt cctttattat tttagcatca ttatatttat tcaaaatttc
      661 ttgctgttgc tgatacaaac tgttgttgtc tgtttgattt tttgtactta cacggcaata
      721 tccatatata ataatcatca cttcctaaca taaagatttt gtacagaagt tacccagaag
      781 cttgttttta cttatcttta tccattttac taaaacgatt tttgggtgtc aatactgtta
      841 acttttgaca ccataataat tcctttataa tttgtttgac tatgtcaaaa attaccaata
      901 taatgaaatt aatgagttta tacaaattgg aggaaataat atgaatagtc tgttaaaaga
      961 agcaatagat gaattaaaaa acatccattg cggggaagtt tttttattaa aagaattgtt
     1021 caaaggctat gaatggaaca ggttggagat gaatatcaga ttgaaattag gaaaactttt
     1081 tttgtatgaa gtggtaacta atcccaattt aaatgtagag gtcatcaata aaaattctgc
     1141 ttatcagcaa atgtataaaa aaaaatagtg acttaaatgt atataatagt ataatcttct
     1201 tattgattca aaagttaaaa cttttaatac aaaacaatca ttctatttta acatttatca
     1261 atatgtctaa atttatataa ttaacacata cgaatagtat tgtttaaatc acattattta
     1321 agatagataa atcttaaccc tactccagca taaatactaa aatagggctt agaattatct
     1381 atatttttat cccataaaat gcttagctct tcctcttgat tgaacatata tatctgggga
     1441 aatacaatag aagcgtaaat ttataaaatt tccaaagtca gaaaacttca gttcaaactt
     1501 aggtatacca aaactttcag gtgctatttc gtcaacgcca aaatagatga taattccatt
     1561 atctgtaaga taaaatgctt ggtcttcagg tataactaac tcaacattag aataatacat
     1621 ttctctattt tcatttattt gagatttaat gtaatcagta attatattaa tataatcaac
     1681 tccatctcta aaaatgtcat taagtaaaag ttcttttcca gttgtcaaat ctatattgta
     1741 attattcaat gtattgtatt taggcccata gttattagca aaccccataa ggtttaatat
     1801 catactcagt acataatttt tattaaaagt aactgcgtaa ctggtagata cccaatagct
     1861 ttgttttgga agtgaatttt gagaagttgc gttattatat tctcgttctt cttcctgtaa
     1921 gccattttta aaattattta cagtcattct tacagcattg tttatgttat ttaaaataac
     1981 tgggtttaca tacgtggatt gatttctaat attgtatata acaggatact ttacatcata
     2041 tgaaaaatac ttacttcttt caaaatcttc attaaattgt acatataata tattatatgt
     2101 acaggtattt gtagattgat aattttccat taaaatcctc ccccttttat aaaaaaatca
     2161 gatacaatat aatatgctta aaacagtaat aatgttaatg gtaaatgtaa agaatagaaa
     2221 gtatctaaaa cagcaaaaaa tgactaattt tgtggtataa tacataggat tgagagttat
     2281 tttataggag gaaaaatatg ttattattag cagataaatg gaaagattat gaacttatag
     2341 atatgggaaa tggagaaaaa ttagaacgtt ggggaagtta tgtacttaga agaccagacc
     2401 cacaggttgt atggccaatg gaatctgaat gggctttatg gaaaaaccct catggacatt
     2461 atcacagaag caataaaggt ggaggtcaat gggaacacaa aaaaagatat ccagaacaat
     2521 ggactataaa ttataaaaac ttaaagtttc acattaaacc aactggcttt aaacatactg
     2581 gattattccc agagcaagca gctaactggg attggatgat agagaaaata aagaaagcta
     2641 acagacctat aaaagtgttg aatctttttg catatacagg tggagctact gtagcatgtg
     2701 catctgctgg tgcagaagta tgtcatgttg atgctgcaaa aggtatggtt aattgggcaa
     2761 aagaaaatat agaattatca ggtcttaaaa atcaaacagt aagatttata gtggatgatg
     2821 ttgtaaagtt tgttgaaaga gaaataagaa gaggtaaaaa atatgatgca ataataatgg
     2881 accctccttc ttatggaaga ggtcctaaag gagaagtatg gcaaatagaa gaaaagttat
     2941 acagttttgt agatttatgt atgggagttt tatcagataa ccctttattt ttcttaatta
     3001 attcttatac aacaggattt tctccaatag ttcttgaaaa tgtattgtct acaacaatag
     3061 gtaaaaagac aaatacagga gatatatacg gtggggaatt aggaatacca gcttccagag
     3121 atggtaagat acttccttgt ggtatatttg gaagatggga gaaaaaataa tgataaaagt
     3181 catatatgaa gataaccatt tattagttgt agaaaaacca gttaacatat tgtctcaagg
     3241 agataatact aatgataaag atatggtaaa tcttttaaaa gactatatta aaaaaaagta
     3301 taacaaacct ggaaatgtat atattggttt aatacataga ttggatagac cagtaggtgg
     3361 agttatggtg tttgcaaaaa catcaaaagc agcatctaga ttgtctgagc aggtaagaag
     3421 taagactttc aaaaaaactt atctagctgt tgttcatggc aagataaaat ctaactcaga
     3481 tatactaaaa gattttttat ataaaaataa aaaaactaat atggtaactg tagtgaaaaa
     3541 aagccataaa gatgccaaag aagctgaact taactataat gtattagatt ttaaagaaaa
     3601 tctaagttta gttcaagtta atttaaagac tggtcgttct catcaaataa gagttcaatt
     3661 tgcaagcaga aaacatccat tatacggaga ccaaagatat ggcaaagaaa taaataagat
     3721 tggacaacaa atatctcttt ggtccaataa gatagaaatt tgccatccta ctacaaaaga
     3781 aaaaatggaa tttacatgtc atccacctga caaatatcca tggaatatat tttaaatctc
     3841 aaatgaggtg attatatgag taaaaaattt tcaataggag aaatgtctaa acttcataaa
     3901 ataagcatac agacactaag gtactatgac caaatagatt tatttaaacc tgttcatgtt
     3961 gaccaagaaa gcaattacag atattactca attgaccaat tttcacaatt agatattata
     4021 aaatatttaa aatatttagg tatgccttta aaagaaatta agtcaaagct tgatgaaaat
     4081 aatgaagaaa ttctaaaatt actaacaaat aaaattaata tagtggatga aaaaattaaa
     4141 gaattagagc ttataaagaa ggtactaagc acaaagaaag aaactatgga aaaaggtatg
     4201 aaagtagatg aagttggtaa aatagtgaga aaacatattc cacgaagaag tatcttatct
     4261 atagagtatg aagaaggatt aagtagtgaa gaaactatgg aactttccag aagacaaata
     4321 gcaaatatat tagaagataa tatatctgtg ttctatggtg gagtaagtgg acttgtatct
     4381 atagataaat ttttaaaaga agataaagtt atttatgaca atagttttgt tactgttgaa
     4441 agagacttat ttgatataaa atcacaaaaa catataacag aaatttcatc tggtgatttt
     4501 atttgtatga catataaagg gccttacaaa gaaaattata ccgcttttaa gaaactggtt
     4561 gattatgttg aatataaaag aatacctatt gaaaattata tatatgaaat acctataata
     4621 gaccctctgt ctacaaacaa cgaagaggaa cttctaacag aaattcaaat acaagttaaa
     4681 aagagagaaa ttgacttaag atgtctagtg tagtaatcta gtttacttac acatcttaat
     4741 atagttgtct attatcaaca tatgattttt ctagatagtg attcctaaca gtgagatttt
     4801 caaaaaatag gaggaaatat ggctaatgct aattccctcc tatttttaat taagccatat
     4861 cattttaatt aagccatgtc atcacgaagt gcatcaataa tattttcttt ttttatctta
     4921 ttaatagtat acaacattgt aataaatact ataaataaaa cactaaatat actaattcca
     4981 atactaaacc atggaatcac aaaatcaata tcatctgtaa ccattacttt atgaattagc
     5041 catgaagaaa ttactgctat aggaagtcca aagaacaatg ctctcatgcc ataaaaggca
     5101 cactcaaaat tcatcatctt ttggaaatca tgctcagaca ttcctacaga gcgaagcatg
     5161 gcaagttctc tacgacgtaa cttaatatta gttgaaattg tattaaacac attggcaatc
     5221 gaaatcagag aaatcataat tatgaaagta taagcaaaaa cattggcaat aaaaatgtaa
     5281 ttacggttct catccatcat tccatacata ttgtacagat tgtactcatt cgtaactccc
     5341 tcactctcaa taatttgctc catttctgca actgactgag taggattttt cgattgaaag
     5401 cttaaacttt caattcctgt agaaacacca ggaatctcaa acttatcttt ggctgaataa
     5461 ggagccaata ctctgaagct tgctttcttc acatctgaac ttctgattcc tggaggagaa
     5521 tcaggtggca ctactttgac aaatgaaata ttcacatttt gtctctcagg tatctccaac
     5581 ttgccattag tttcaggagt gaggctaaca ttcatagaag aactgttgaa aatatcaata
     5641 atattattat cctttgttac catagaaaca gcaatcagtt ttgcattttg tccagtatat
     5701 tcttctgctg gtaatccaag acttttaata atattcagat aagttctatc atcaagaaat
     5761 tgcatatcta ctggtaattc aagcatttca ctcatagaat gtgaaccctc atagttcaaa
     5821 taatcgtctg taagctcact tactttggca acacatgaat aggtcataag tttctgatac
     5881 aaaccttcgt aaacaccatt tgcagttttt agcttatcgt aaagcttcaa catttcgttg
     5941 tctttcatac cttgtgtaga aaaaataata tcctggtcag taacctctga cctctgattt
     6001 gacatctgtt ttaggtctgc tactaaagca cttgtagata taaatagaac tatgcttaaa
     6061 acaagcgaca atacaatact tcgataacgt ttcttgtttc ttttaaagtt tttcatagca
     6121 agaactccct caagaccata aactcgctgt gttagttttg atgtcttcac agatttagat
     6181 tcaattttta cctcatttgt ctgacgaata cactccatca ctggtgtgtt ggcagccttt
     6241 cttgctggta tgtaagcaga aattaagatt gtaaccatac ttaccactgc tgcaacgatg
     6301 attgcaggga tagacaatgt taatgtcaac ggaacgttta catagagaat atttgcaaag
     6361 tttttagcta tgacagaaat cacaagtcca atactgacta taccgattgc aacaccaatt
     6421 ggtataccaa tcgcaccaat gcaaattcct tcaaatagca ccgaatttcg taactgtttt
     6481 gctgtagctc caacagatga aagtattcca aattgatgtg ttcgctcgtt caatgacatg
     6541 ttaaatgaat tatatattag aaaaattgag cctagcatga ttatggcaag cacaatgcca
     6601 ccaaccgagt acaaaaacat attgaacaaa ttgttatcag aaacacctat gaagcgcaac
     6661 acattgtcat tgaaaatgga agcatggtct ttagtgctac ttatgtaaga gcgaatctga
     6721 tgtggatttt tcaatgtgac aaaaaggcta agactgtcag tcttgacttg tttatcttct
     6781 ttggttatca aggtatatcc tggtgcagaa gattcttcaa atacgggctt tctacagata
     6841 cccacaactg tataagtttt cttatcctgt ggcacaaaaa cttcactccc agcagtgtat
     6901 gggtcactct gaccaagctt ttcattttca ctcattcgtt tccctacatc caaagaaata
     6961 gtatcaccta ctgcaaattt gacaccacca tctgtcgcaa ctttacttga aacaagaatc
     7021 tctctactat tttcaggtaa tcttccagaa attaaagtta taggcaaagt atcaaaagct
     7081 tctttgctaa atccagcaat aaaaagatat ggtttatctg gatttctgtt accttcaagt
     7141 gttgcatagc caatattttc aaatgttgca gtatttgcaa cttcatcatt gactctttgt
     7201 tcctgtacaa aagaagaatc cacatccaaa aactggacat gccaatcacc atattttata
     7261 atagctccat ttgtcatata gttcatcaaa gaaactccaa aggtagtaac tgctgtaatc
     7321 atagcagctg acagaacaac tcctataatt gttacaagag ttcgagtgcg attctttttc
     7381 aatccttgca gagcaacttt gttaaaaatg ttcattaacg attcaccttc ctctcatcac
     7441 gcactacttt tccatctgaa atacagataa ttctatctgc ctgtaaagca atgttttcat
     7501 catgtgtgac aataatgaga gtttggtgat atttactatg gctctctttc agtaactgga
     7561 taatctcttg tccattttta ctgtctaagc tacctgtagg ctcatcagca agcataactg
     7621 ctggtgcatt catcaatgca cgaccaatgg caacacgttg ctgttggcca ccagaaagtt
     7681 gatttggtaa atgtgttttt cgttctttta aaccaagcaa ttctaacaag tcatttaacc
     7741 gttcttgatt gaccttacgc ttatccataa gtataggcaa tgtgatattt tctactacat
     7801 ttaatgtggg tatcagattg tgaaactgat aaatcaatcc aacttgtcgc ctacgaaaaa
     7861 tagcaagttt ttcattgctt tggccatata catcttgccc ctccagatat atctttccac
     7921 ttgttggtac gtctactcct gcaatggaat gtagtagtgt agatttacca gaaccagaag
     7981 aaccaatgat tgcagtaaac tctccttttt caatagtaag tgagacatgg tcaagtgcag
     8041 taaccttatt ttcattctta ccataaacct tacataaatc ttcaatcttt aaaaacgcca
     8101 ttatataagt ctcctttcat attttataaa tatatcatag gactttcaac ttacatttaa
     8161 gtgacattta aatgagagat tcgtcacttt ggaaaacgaa taacaaatat tgcaccacct
     8221 tgtgggtgat tttgtgcagt aattgttcct ccttgtctca taataatcgt cttacaaagt
     8281 gccaatccta ttccataacc ggctgtgctt gaatttttcc cacgataaaa tctgttaaat
     8341 agacatggta aatcttcttt tttaaagcct gctccgttgt catgaatagt aagttgagta
     8401 aacaaaaagt tgtcctcaca aatgatatca atttttccat tatcacccac actctccatg
     8461 cagtttttaa atatattttg aattgcttct gaaagccaat ttaaatcacc caaaatcctt
     8521 actccttttg gtatatcaat atgtaaagtg atattgtgca gttccatggg aatcaaaagt
     8581 tgatgaagtg cagaactaat caaattattc acatcaattt gttctttttg aaagactaca
     8641 atacctgcat ctaaacgtga taattttaaa agggaagtaa tcagccagtc cattcgtata
     8701 agtaattcct ctgtttctcg tatcaactct tttctctcat cttcatcaga agtattctct
     8761 aacagtgaca aaataagagt tactgatgta agaggagtgc gaagctggtg ggctatgtca
     8821 gctagtgagt cagcaaggtg ttctttttct tttttcaatg cgtaattttg ctctctaata
     8881 cgtaacgtca ttttagttat ttcactttgc agaatagaaa gttcaccctc atctgattca
     8941 gcaatataca gatggttagc attatgaagc acaagattaa tttgttctga aatctgtgca
     9001 atacttttgt atcgattttt agtaaacaca aaaaatgcta ttccaaaggt agtggcagaa
     9061 acaatagaaa gtattccagt cataatactg attgcaaatc ccagggctac agtgagaata
     9121 gtaattaata agaataaaat agcaaatttt cgaaactctc tatttcgaaa cataacttcc
     9181 ccccaatcta taccctgtcc cacgaacagt caaaattatt tgtggacttg aagggtcatc
     9241 ttctatcttc tctcgcaagc gtttgatgta cacagtcaat gtgttgtcat taacaaactc
     9301 acctgccgca tcccacaatt catcaagtaa tcttaccctc gtaataatac ttttaggatt
     9361 gctaataaac accaataaca aacggtattc taaagctgaa agaaaaacct cattgccatt
     9421 ctttttcaca acaccggttg ccgtatctac ataaagccca caaatttcaa aagttgaccc
     9481 aaaacgccca ctttttcgta gtgctgttct aattcgcgca atcagttcac gtggacgaaa
     9541 aggtttagta atataatcat ctgcacccat attcagtcca gtaacaacac ttgattcatc
     9601 accggaagct gtcaaaaaga taacaggaat gtcttgcttt tctttgattt ctgtgcaaat
     9661 cgtaaaccca tttccatcag gtaaagaaat atcaataagt gccaaatcaa atttattctt
     9721 agcaatctct acaagtgctt cacttcttgt ggatacatgg gttactataa atccttctga
     9781 attaagcaaa agaataagat ttttggcaat tgctttatca tcctcaacta aaaatatccg
     9841 tttcatttac tttcatcctc ctttatttta ttagttttat atattccagc agagcaatag
     9901 tacactacta ttttacttat cattacacaa ttttcagtag tttcttttgt tcttatataa
     9961 tccatgcata atacctccat tgatttatta tatttcttat aacataaata cacaagataa
    10021 gacaaaaaac ataatgtaag tgcaagtttt ttaactcact aacttataaa catacactcc
    10081 tactaacact actttcttga tgacacatct tacaagctta tattcataca tcaatgaaaa
    10141 attaaattta tccatttatt aaaataaaag gcaatagctt ctatagctaa tgccctttat
    10201 cttaaaatga tttaaatact atacaatttt tataaatggc tataaataaa ctcgtataga
    10261 atataaaatt tatctacagt cttttgttat acaaaattta taacctctta tagaacaaat
    10321 ttaccacttt gcaaacttat cacttttact cagctatatt ataaactttt aatttatctt
    10381 tgtttaaatg tttcttctta acttctacta aagcttttag cgtatccaaa gatgtcatta
    10441 tttcagtaga aaattcaatg gctgttcttc t
//
LOCUS       DAEQCW010000120        10234 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.121, whole genome shotgun sequence.
ACCESSION   DAEQCW010000120 DAEQCW010000000
VERSION     DAEQCW010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10234)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10234)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10234
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.121"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            419..907
                     /locus_tag="KRO40_003067"
     CDS             419..907
                     /locus_tag="KRO40_003067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH2093870.1"
                     /translation="MKNKKGFTLVELLVVIAIIGILAIVALPALFKNIEKAKIAKLEA
                     DISAIKSASLSYYADESKYTEGNIIWWTKKDGKITVNSGIGDEDPLAHKIENLGMPYN
                     GSYTLVSSNGSEEYLELNIIIDGEISKSGLDKLEEDYGSSIKIPNDKNMIITFLSNKS
                     DN"
     gene            1296..1466
                     /locus_tag="KRO40_003068"
     CDS             1296..1466
                     /locus_tag="KRO40_003068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093871.1"
                     /translation="MHVYQPKTSEYLLNTSAKSYLSSIVFLFDYITKNESRYAFFIID
                     FPFLSLDIFYKF"
     gene            complement(1943..2131)
                     /locus_tag="KRO40_003069"
     CDS             complement(1943..2131)
                     /locus_tag="KRO40_003069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2093872.1"
                     /translation="MTKYDFNFKLKVAKFYLNREGRDILIVKQYGVYDHSQVERWVNI
                     LGESELKIKKFSILYGSS"
     gene            2293..2643
                     /locus_tag="KRO40_003070"
     CDS             2293..2643
                     /locus_tag="KRO40_003070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3796 domain-containing protein"
                     /protein_id="HBH2093873.1"
                     /translation="MIQKKFFMGFCGFLGFLSLRYFSSGNVADLTYIGFFAFFSNFII
                     AKINGDKADERYVQDEKAAMAFTGQLAIIELFILWCITIVSRNIELMCVLLSITYAIT
                     LNVYAIKLYILEEK"
     gene            2645..2845
                     /locus_tag="KRO40_003071"
     CDS             2645..2845
                     /locus_tag="KRO40_003071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093874.1"
                     /translation="MPKFTCNLKKYRQLKELTQEQLAEKVGVRRETIMRLEAGKYNPS
                     LKLAIDISKIVDTPIDELFIFD"
     regulatory      3025..3114
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            3168..3344
                     /locus_tag="KRO40_003072"
     CDS             3168..3344
                     /locus_tag="KRO40_003072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093875.1"
                     /translation="MFRDKMDKCTHMLTAYIGSSYDYCDFIDTHLDDFILEYGEKVVE
                     SCLHQVMVLVSKYN"
     gene            3569..3769
                     /locus_tag="KRO40_003073"
     CDS             3569..3769
                     /locus_tag="KRO40_003073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH2093876.1"
                     /translation="MNNGIVKWFNNEKGFGFISMESGDDVFAHFSAIQTSGFKSLEEG
                     QKVSFDIVKGARGPQAENITIL"
     gene            4406..5218
                     /gene="modA"
                     /locus_tag="KRO40_003074"
     CDS             4406..5218
                     /gene="modA"
                     /locus_tag="KRO40_003074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2093877.1"
                     /translation="MFKKLSVLALAMIISLSITACNSKENKANDESNTKVTTADDSKE
                     KETLFVYSGAGLKKPMDEIAKKFEKENNVKVEYSYAGSAQLIAQIETSHKGDVFIVGS
                     EPIYSKAFEKELVGEHKTVAHHTPAIVVPKGNPANIQKLEDLNKDGVKLILGDKESNA
                     IGKTTQKILEKNNLKSINDNVVSTAATVNEMIVQLTSSKADATIATKDSVFGNEDVEV
                     IEIAQDKNIDQLISAGIVNYSDKKDLANKFINYIESDEAKQIFKKYGFEPVK"
     gene            5228..6019
                     /locus_tag="KRO40_003075"
     CDS             5228..6019
                     /locus_tag="KRO40_003075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093878.1"
                     /translation="MKNKFFTTLLTGFFAIVFLFIVSPLLMLIIKGISYVPICLKSVE
                     VQYAITLSIKTSLISTIVCLLLAIPVAYFLHITKLPFKKLIIQIINLPMSLPHLVSGI
                     ALLLLFGRMGIGDSIYKIFKLDFIFTKQGIVLAQIFVNLPLTIKILHTSLNESNEKMI
                     FVARTLGCNSWEAFRFIILPNLKTGIISATVMTWSRALGEFGAVAMIAGSTRMKTEII
                     PTSIYLNMSTGDIDIAIGIAVILIFISLTCLMLFEIFFNREVDKN"
     gene            6021..6716
                     /locus_tag="KRO40_003076"
     CDS             6021..6716
                     /locus_tag="KRO40_003076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2093879.1"
                     /translation="MLKIKNLSLDLPNFKLQENSLNINNHEYFVLLGASGSGKTLFLE
                     TLAGRYPSAKGNVSYKENLISNLPPENRNIGFVYQNFELFPNMSVEDNIRFPLKLRKI
                     PIDEQILKANHLSKLMQIEDIKNRYPKNLSGGEKQRVAFARALIAEPDILLLDEPMSS
                     LDYITKKHISKILKDVYIKYKPTVIHVTHDISEAMFFAHKIGIMNNGKINHIFDLNEE
                     IKNKGESFFYEYI"
     gene            6703..7434
                     /locus_tag="KRO40_003077"
     CDS             6703..7434
                     /locus_tag="KRO40_003077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093880.1"
                     /translation="MNIFDILRDYLLVQVDKYNLNMDMISIVSKSLSSKEAIGNTKRK
                     DFPIIVGKEIMLEADFKGAKGQAFTSTPSTFEGSLKDILSLDLHDNPHDRSLFIASLN
                     AVMKYLGKTDRTIHCKNNEPEVCAKKFPEFIKMEFGNPKVAIIGYQPAIIDNIKDFFE
                     TRVLDLNPEFVDTIQYNVKIEDGIRDYEDVISWADLVICTGSTLCNNSIINFLSLNKP
                     VYYYGTTIAGASNILGLERLCFCSK"
     gene            7748..8548
                     /locus_tag="KRO40_003078"
     CDS             7748..8548
                     /locus_tag="KRO40_003078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423139.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBH2093881.1"
                     /translation="MTFKNKKFTINKYKILSIILVLCLILTAFSSYVNYSHKKFKDYV
                     VFYVQHQDDEVLWAGSAIVNAIKERGKNHVFVVLVSTGCGISVFDKYKKYENLTNIQK
                     SEYRNREFLASLNSLGVIRENIILLPETNTNGNTDFNYMEKIALTFEEKFKNVTHIAH
                     TYKLDDHLQHLKNGSVIQNLYNAGKIKDAKYFVKPKFADKITFNNKIVYKAHSTEDYE
                     KVKNACQQYKIVDELEYREGIGYKSDHKSFDKLLNNKDVPAILHTPNL"
     gene            9088..9804
                     /locus_tag="KRO40_003079"
     CDS             9088..9804
                     /locus_tag="KRO40_003079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093882.1"
                     /translation="MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIE
                     NDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLSAKSEDMDKIIGLNMGADDYITK
                     PFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
                     KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPK
                     EPKYLKVVWGIGYKIEKLNY"
BASE COUNT         3919 a         1182 c         1394 g         3739 t
ORIGIN      
        1 catattttga cttattatac tgatagttca tataattatt ttgattttat agatacacgg
       61 ttagatgatt ttatactaga acataaaaaa atgtagtata atcttgttta tatcaagtta
      121 tggtattggt aagtaagtat aattaaatag acattatttt ctgggccctc tttttatttt
      181 catctgcttt taaataatat tattggcgtt gatatgactg tagttttctt tattttaatc
      241 cattgcttat atcttttcta acaagaaatg tcattttaaa tcatttccat aaattgtaaa
      301 ataatagtat atttgtcata gaaagtgatt tttttgtcta tatatggtaa aatatagaaa
      361 gtagaaatca acaaaataaa aatttatata ttattaattt tatatggagg ggaaataaat
      421 gaaaaacaaa aaaggattta ctctagtgga attattagta gtaattgcta taataggaat
      481 attggcaata gtagcacttc cagcattatt taaaaatata gaaaaagcaa agatagctaa
      541 acttgaagct gatataagtg caataaaaag tgcgtctctt agctactatg cagatgaatc
      601 aaaatatact gaaggaaaca taatatggtg gactaaaaaa gatggaaaaa taacagtaaa
      661 ctctggtatt ggtgatgaag accctttggc acataaaata gaaaatttag gcatgcctta
      721 taatggttcg tacactttag tgtcatctaa tggtagtgaa gaatacttag aattaaacat
      781 aattatagat ggagaaataa gtaaaagtgg tctagataaa ttagaagaag attatggtag
      841 ttcaataaaa ataccaaatg ataaaaatat gataataact tttttatcta ataaatcaga
      901 caattaaaaa taaatatata ggtctgataa ttattgttaa agtaaaaaga gttggttata
      961 aaaatgaaaa aagcactcct caagaataga atgcttagtt ataactacag aagtgtattg
     1021 gcatacactt ctatttttta ttatatcaca taatttaaaa atacctattc aagttgtttt
     1081 taaattatgt tgagtaatat tcttgatagt ttatacatta atgaatttca aaaaaataag
     1141 tactctttat agtaaaaagt actttagtgt atgttaatgt cctatctaat aaaattgtaa
     1201 catgccttat gctttagtat gataattttc attttcttta ttgttgcaac ttatactata
     1261 gttttgctaa tttatctgca aacacaactt ctttattgca tgtgtatcaa ccaaaaacat
     1321 cagaatactt acttaataca tctgcaaaat cgtatctttc atctatagta ttcttatttg
     1381 actatataac aaaaaatgaa tcgagatatg ccttttttat aattgatttt ccatttttat
     1441 cattagatat attttataaa ttttagcata tcatttgtta ttttctgata tgctattgat
     1501 gttttaaatc ttctatttgt tttattattt tttacttttc caattataca tttataggag
     1561 ttatatttat gtgatttatg aaaaaatgct atgcatttaa gttctaattt tttgataata
     1621 catctaactt tcttttgatt aataatgata ccactgtttt ttaatgtggc ttccctgagg
     1681 cacacatctt ttttaaaaac tcaagctcat cttttaaaaa tttattttca tattctaatt
     1741 cttgttctct tgttaattta ttttttcttt agtgtttttg tttttattca ttatggtctt
     1801 cctttcattt tggaaaaggc atcaacacca ctatgtaaaa atttttattt tcatgttgct
     1861 ataactgtgc tattgtttat tccaaaatac ttagcgattt attgtacact atatttagtt
     1921 atcatcatat agtttataac atctaacttg aaccatatag tatagaaaat ttttttattt
     1981 ttagttcact ctctcctaat atattaaccc atctttcaac ttgagaatgg tcataaactc
     2041 catattgttt tactattaaa atatctcttc cttctctatt caaataaaat ttagctactt
     2101 ttaatttgaa attaaaatca tatttagtca tacataaaca tctcaagcag tagatttttg
     2161 ctctaacaat tatggtgcag tacaaatatt gtataatact gattttctat tgacaaaaga
     2221 atataaaaga gatatatttg tatcataaag atataaatat atctctttta aaattactaa
     2281 ggaggataaa aaatgattca gaaaaaattt tttatgggtt tttgtggttt ccttggattt
     2341 ttaagtctta gatatttttc atctggcaat gttgctgacc ttacatatat tggatttttt
     2401 gcttttttct caaactttat tatagcaaaa ataaatggtg ataaagcaga tgaaaggtat
     2461 gtacaagatg aaaaagcagc tatggcattt acaggacagc ttgctattat agaattattc
     2521 attttatggt gtattactat agtgtctagg aatatagaat taatgtgtgt tttactatca
     2581 attacatatg caatcacttt aaatgtttat gctataaaac tttatatttt agaggaaaaa
     2641 taatatgcct aaattcactt gtaacctaaa aaaatataga caattaaaag aattaactca
     2701 agaacaatta gcagaaaaag taggagttag aagagaaacc attatgcgtt tagaagcagg
     2761 aaagtataat ccttctttga aattagcaat agatatatca aaaatagtag atacacctat
     2821 tgatgaattg tttatttttg attagttttt gcattattaa aaatgtgttt taaatacaaa
     2881 cttaaattca atttttaagt cactcctgac agaggggctt tttatttttt cagataattt
     2941 aacgttcata tataaattta ttaatttttc agctagatat gttgaataat aactaattct
     3001 attgtattat taatctgtag aataaaacta aatcggcaaa actagagaaa tttagtgacg
     3061 caaagctata gggactaacg cttataaaat aagttatgtc agccagttgc caaaaagata
     3121 ttttcttttt gtttttcatg aaagtttttt agggggataa atacattatg tttagagata
     3181 aaatggataa atgtacacat atgttaactg cttatattgg tagttcatat gattattgtg
     3241 attttataga tacacattta gatgatttta tattagagta cggagaaaaa gttgtggaat
     3301 cttgcttgca tcaagtgatg gtattggtaa gtaagtataa ttagacagat ttttttctag
     3361 aaaacccttt ttagttttat ctacatttac attaatatat tggtaatata aaatgtttaa
     3421 atttattttc atattaagaa taaataaaaa tgttaactaa aaattataat taaatagaca
     3481 tttatgttaa tctatgatac aatagtattt gtggtaatac acaagtaaat caagtatatc
     3541 ttgatatagg ttaataggag tatttttaat gaataatgga atagtaaaat ggtttaataa
     3601 tgaaaaagga tttggattta tatcaatgga aagtggagat gacgtatttg ctcatttctc
     3661 agctatacaa acttcaggat ttaaatcatt agaagaaggt caaaaagtaa gctttgatat
     3721 agttaaaggc gctagaggtc ctcaagcaga aaatataact atattataat atatagattt
     3781 ttcggaaaga ctcttttaag agtctttttt ttatttacgc attttgtaaa aaaggaaaaa
     3841 ataacttcaa caagaaaata cttaaaaata atacttagtc taaatacttt ttataaaata
     3901 aatctgacaa aaatatattt ataaagtatg tacttaaacc tacaagtact cttttaatta
     3961 gaatatatag taatataata attttagttg tggcacatca aaattttcaa ctatctcata
     4021 aatacatact ctttcttttg tattcaattc tgatataaca cttttagtaa tttgttaata
     4081 aaaaacaatt aaaacatatc tatatgtttc aatgttctat tttttcactg aaatataata
     4141 aatataaaat tagttaaaaa gtaaaaaatc tacaataagt taatttgatt taagttttta
     4201 atttttatta atactttaaa gtattaataa aaattaaaaa taaaataact acctatggaa
     4261 atgacattat aaatagattt tttcttaact atacataaca aaacataaca aaacattata
     4321 aaacataaca aaaacttaga catcgttttc ttagtatgat atactaaaaa agaatttaca
     4381 ctaatttact aagggggaat atcttatgtt taaaaaactt tcagtactag ctttagctat
     4441 gattatttca ttaagtatta ctgcatgtaa ttctaaagaa aacaaagcta atgatgaatc
     4501 taatactaaa gtgacaacag ctgatgattc aaaagaaaaa gagactcttt ttgtctattc
     4561 aggggcaggt ttaaagaaac caatggatga aatagcaaaa aaatttgaga aagaaaataa
     4621 tgtcaaagtt gaatatagct atgcaggttc tgcacagcta atagctcaaa ttgagacaag
     4681 tcacaaagga gacgtattta ttgttggttc tgaaccaatt tattcaaagg cctttgaaaa
     4741 agaacttgta ggtgaacata aaacggttgc acatcataca cctgcaatag ttgtacctaa
     4801 aggaaatcca gctaatattc aaaaattgga agacttaaat aaagatggag ttaaacttat
     4861 tttgggagac aaagagtcta atgctatagg taagactaca caaaaaatac ttgaaaaaaa
     4921 taatttaaaa tctataaatg ataatgttgt ctctacagct gcaactgtaa atgaaatgat
     4981 tgtacagtta acatcaagta aagctgatgc tacaatagcc acaaaagatt cggtctttgg
     5041 taatgaagat gtagaagtta tagaaattgc ccaagataaa aatatagacc aacttatatc
     5101 agcaggaatc gtaaactata gtgataaaaa agatttagct aataaattta taaattatat
     5161 agagtcagac gaagctaaac agatatttaa aaaatatggt tttgaacctg ttaagtagtg
     5221 attaaacttg aaaaataaat tttttactac tctacttact ggattttttg ctatagtctt
     5281 tttgtttatt gtatcaccac ttcttatgtt aatcattaaa gggataagtt atgttcctat
     5341 atgcttaaaa tcagtggaag tacagtatgc aataacactt agtattaaaa catctttaat
     5401 atctactata gtatgccttt tattagctat tccagtagca tattttttac atattactaa
     5461 attaccattt aaaaaactga ttatacagat aataaatctc cctatgtctc ttccacactt
     5521 agtatcagga attgctcttt tacttttgtt tggaagaatg gggattggag attccattta
     5581 taagattttt aagcttgatt ttatatttac aaagcaaggt atagttttag cacaaatatt
     5641 tgtaaatctt ccacttacta ttaaaatact tcacacttca ttaaatgaaa gtaatgaaaa
     5701 gatgatattt gttgcacgta cccttggatg taatagttgg gaagcattta gatttataat
     5761 tcttccaaat ctaaaaactg gaatcatatc tgcaactgta atgacttggt caagagcact
     5821 tggtgaattt ggtgcagtag ctatgatagc aggttctaca cgtatgaaaa ctgaaattat
     5881 tcctacatct atatatttaa atatgtctac tggtgatata gacattgcaa tcggaatagc
     5941 tgtaattttg atatttatct cacttacatg cttgatgctt tttgagatat tttttaatag
     6001 agaggttgat aagaattaat atgttaaaaa taaaaaattt atctcttgat ttacctaatt
     6061 ttaaattaca agaaaatagt ttaaatatta ataatcatga atactttgtt ttattaggag
     6121 ctagtgggtc aggtaaaact ctattcctag aaacattagc aggaagatat ccatctgcta
     6181 aaggaaatgt atcatacaaa gaaaatttaa tatcaaactt acctccagaa aatagaaata
     6241 taggatttgt atatcaaaat tttgaattat ttccaaatat gagtgttgaa gataatataa
     6301 ggtttccact taaattaaga aaaataccta tagatgaaca gattcttaag gctaaccact
     6361 tgtctaaatt aatgcagata gaagatataa aaaataggta tcctaaaaat ttaagtggag
     6421 gcgaaaagca acgagttgct tttgcacgtg ccttaatagc tgaacctgat atattacttt
     6481 tagatgaacc tatgagttca ttggattata ttacaaaaaa acatataagc aaaattttga
     6541 aggatgtcta cataaaatac aaaccaacag tgattcatgt tactcatgat atttctgaag
     6601 caatgttttt tgctcataag ataggaataa tgaacaatgg aaaaataaat catatttttg
     6661 atttaaatga agaaataaaa aataaaggag aatctttttt ctatgaatat atttgatatt
     6721 ttgagagatt atctattagt acaagtcgat aaatataatt taaatatgga tatgataagt
     6781 attgtgtcca aatctctatc ttcaaaagaa gcaattggaa atactaagcg taaagatttt
     6841 ccaattatag ttggtaaaga aataatgctt gaagctgact ttaaaggagc taaaggacaa
     6901 gcatttactt ctactccatc tacatttgaa ggttctttaa aagacatatt atcattagat
     6961 ttacatgaca atcctcatga tagaagtctt tttatagcat cattaaatgc agttatgaaa
     7021 tacttaggca agacggatag aaccattcat tgtaaaaata acgagccaga ggtatgtgca
     7081 aaaaaattcc ctgagtttat aaaaatggaa tttggtaatc caaaagtagc aattatagga
     7141 tatcaaccag ccataattga taatattaag gactttttcg aaacaagagt attagattta
     7201 aatcctgaat ttgtggatac tattcaatat aatgttaaga ttgaagatgg tatacgagat
     7261 tatgaagatg taatatcttg ggctgattta gtgatttgca caggaagtac attatgtaat
     7321 aactcaatta taaattttct atcacttaac aaaccagttt actattatgg aactacgata
     7381 gctggtgcat caaatatttt aggtttagaa agactctgtt tttgtagtaa ataagcaatc
     7441 atatcatcaa ggagtacaca aatatatatg tgtactcttt aaatttaaaa agttattact
     7501 tttattctaa gtactaaagt aaaattctat taaaatgaat cccgaataaa tgtacaatcc
     7561 ctttaaatct caattcctat caatcattaa tattttgatt agtcttatac ataaatgttt
     7621 tctttatttt aaactaataa aaaaatttta ttccattaat ctactctata tttttcagca
     7681 tttaagaaat aatttttagt actttgtttg ataatataac taagacaact tttcaggaga
     7741 tgattaaatg acatttaaga ataaaaaatt tactataaat aaatataaaa ttctatctat
     7801 tattctagtt ttatgtttga ttttaaccgc ttttagtagc tatgtgaatt atagtcataa
     7861 aaaatttaaa gattatgttg tcttctatgt tcagcatcaa gatgatgaag tgttgtgggc
     7921 tgggagtgct attgttaatg ctataaaaga aagaggaaaa aatcatgtat ttgtggtttt
     7981 agtatctact ggatgtggta tatccgtctt tgataaatat aaaaaatatg aaaacctaac
     8041 aaatatacaa aaatcagaat atagaaatag agaattttta gcttctctta atagccttgg
     8101 tgtaataagg gaaaatataa tattattacc agaaacaaat acaaatggta atactgactt
     8161 caattacatg gaaaaaattg ctcttacatt tgaagaaaaa tttaaaaatg taactcatat
     8221 agcacatact tataagttag atgaccattt acaacattta aaaaatggtt ctgttatcca
     8281 aaatttatat aatgctggta aaataaaaga tgctaaatat tttgtaaaac ctaaatttgc
     8341 tgataaaata acttttaata ataagatagt ttataaagct cattctactg aagactatga
     8401 aaaggttaaa aatgcctgtc aacaatacaa aattgttgat gaattagaat atagagaagg
     8461 tattggctat aagtctgacc ataaatcatt tgataagtta ttaaataata aagatgttcc
     8521 tgctatactt catacaccta atttataaga aatatttatt cttttaattt aagttataaa
     8581 aaggaaatta tttgagattt tgtgatatag cactttttgt gctatactac tttttctcat
     8641 acaactatta cccatatcta atttcatcat ctcttaaaat atataaagat atcatcatta
     8701 aaacctataa gccttattaa atgctttata catacctaca ttaaactacc tgtttatatt
     8761 aaactacatt aaaataaata tttgttataa attcttaata attatgaaac tcatttgtta
     8821 tttatatttg ttaatatatg tttaaaccta aaaaattaat aaaccaaaat aacataagaa
     8881 gtgtgataga ttaccctaga tattttcata aacttttacc ttcagattaa tatgggcgtc
     8941 tatactttta aatttactat atgcattgac aatatattaa aagtactagt ttttatttca
     9001 taatgaacgg gcttactgtt ttctaatacc tctttttggt ataaaataaa aattggttaa
     9061 aaataaaatt tcaagggggt taataagttg aatcaaaata tattggttgt agatgatgat
     9121 agagagatag ttgatgctat agagttctat ttgagacctg ataactttaa tgttttaaag
     9181 gcatatgatg gacttgaagc attggacata ctaatcgaaa atgatattaa gttaataata
     9241 atggatgtaa tgatgcccaa tttagatggg cttaaaacta cacttaaaat aagagaaaaa
     9301 aggaatatac caataattct cttatctgca aaatcagaag atatggacaa aattataggt
     9361 cttaatatgg gtgctgatga ttatataact aaaccattta atccactaga acttactgct
     9421 cgagtaaaat ctcaacttag aaggtatata aatttaggtg attttagtaa tacaaataac
     9481 tcaaatgata ctaattatat tctaaaaagt ggtggcctag agctaaatac agatacaaaa
     9541 atagtttctt tagatggtga ggaaattaaa atgacaccac ttgaatataa aatacttaca
     9601 cttcttatgt cacgaaaagg taaaattttc tcttctcatg agatttatga aaatgtctgg
     9661 aatgaggatg cttatagttg tgagagaact attgctgttc atattagaag aattagagaa
     9721 aagattgaaa ttaatccaaa agaaccaaaa tatttaaagg tggtgtgggg cattggttac
     9781 aaaattgaaa aacttaatta ttaatgattc taaagcaaaa tttattttat tattattact
     9841 gtttctatta gtttctatat tatttgaagc agtttatgat ttgaataata acttttctta
     9901 taatattaat tgttattata aagagtttgc tctcccttat ttttattttt tcggtactcc
     9961 tgtacatttg tcaaaagtag aattagagtt tgtctgcata ggtattatat tatcaagttt
    10021 tttattgact atactatgtt ttacattgta taaaaaaaat aaacagacta aagtcaaatt
    10081 cttagagaat gttataagcc ttttttctaa ggtaaaaata gaacttacac ttatattaac
    10141 tttgatacta ttaaccttaa ggtttcatgc atttacaagt aataaaatgt tttacaacac
    10201 taatttaata atctacaatt ttataattat atct
//
LOCUS       DAEQCW010000121         9852 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.122, whole genome shotgun sequence.
ACCESSION   DAEQCW010000121 DAEQCW010000000
VERSION     DAEQCW010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9852)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9852)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9852
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.122"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            511..2745
                     /locus_tag="KRO40_003080"
     CDS             511..2745
                     /locus_tag="KRO40_003080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093883.1"
                     /translation="MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNRE
                     FMYQHIDDCISKNIHIGIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKG
                     IVAYLKGEGFLIVLPNVSNKELNNMGATIIESARELKIKLPNEKEIYSNVTFSIGSTI
                     WNGEPNMTTLMLFNQVYSALKKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHV
                     LQTKQIEVFYQPLYNIKNNTIVGCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDL
                     HLFEENCKNIRRWIDNNDVFVPICCNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIE
                     ITENILIENTNTIIQQLAELRSYGFSVSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLS
                     HNLNDFKNTTILYSIINIARALGMLTVCEGVETEQHVEFIKSINCDIAQGYYYAKPME
                     CKEFEKLLSKENNSEKMFIKYSDIGKSLIEKIFDGFFIMQDMKKLRANVTEDIQWFDF
                     YNKTEITSFPKVIEHFEKHIKGKKFSILYKSITPHNTESDSLLISGEAVLSDEASEHQ
                     KYSNFYFSANCIISENKLLLAKLHLDLIKTAGYINEFESYSIPKMTNTHLDESNILSQ
                     FYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKEQFFGEMGGNLRAIVHPDDLDFV
                     YKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLSAIDGRSIAQGMYVDVNKIKN
                     LTKI"
     gene            2776..3609
                     /locus_tag="KRO40_003081"
     CDS             2776..3609
                     /locus_tag="KRO40_003081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2093884.1"
                     /translation="MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLG
                     MTNIEIAKKLPDNIAKFFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYK
                     VDVDEKTYIITMANDITKLYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVL
                     IDLDNFKMINDYEGHNVGDKILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKN
                     YVYSQLEALRENFLKVFSKYKYLSFSYGVDTVKRNLKLTIVELDKKMYKNKKKFDKND
                     Y"
     gene            3849..5582
                     /locus_tag="KRO40_003082"
     CDS             3849..5582
                     /locus_tag="KRO40_003082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2093885.1"
                     /translation="MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQ
                     EFLTSFNEIKNYFYAGQDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENTQMIL
                     EVNQRCTFEIIEDRGKLLVKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTE
                     VIEMITNNINGGLKGSNDDNTYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPD
                     LPKALEDCERCFAKGPTYSSEYRIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDIT
                     QLKNIESELKLERERYRIALQNITDIMFEYDIENDTLIKYQRVEIDKKIELENFETKN
                     YSKLLESGKIIHLDDIGKLLEVLHGNLRETIEIRQVNSLTKNEWRWIRVQCSVIYDSD
                     HNPIKTIGVLKDITEDKSKLESLINQAQRDPLTQLYNQRVSQNLIEEYLCSSDSKNND
                     ALLVIDIDDFKTVNDTFGHLEGNEVLVAVSKILLHNTHDKDIVARIGGDEFTIFIKSL
                     TKDLIIKITNDILNDASKIKVKDNHKITLSIGIAFTDDSTKLYKDLFSKADKALYLSK
                     ADGKNCYSTYE"
     repeat_region   5914..6268
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=6043..6071
                     /rpt_unit_seq="atttacataccacttagttaatataaaac"
     gene            complement(6798..6902)
                     /locus_tag="KRO40_003083"
     CDS             complement(6798..6902)
                     /locus_tag="KRO40_003083"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HBH2093886.1"
                     /translation="MDDYIYYYNNFRYQNRLNSMSPFEFRKYLSTERA"
     gene            7527..7772
                     /locus_tag="KRO40_003084"
     CDS             7527..7772
                     /locus_tag="KRO40_003084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093887.1"
                     /translation="MNQKKIKISIKMVIIGIFAVIIAFVLSRLFVEYIDELLRSNWQY
                     QLFESESSYIVFANCIMFSNILLEIFLIYICRKFRKI"
     gene            8767..9416
                     /locus_tag="KRO40_003085"
                     /pseudo
     CDS             8767..9416
                     /locus_tag="KRO40_003085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429361.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase family
                     protein"
BASE COUNT         3952 a         1183 c         1228 g         3489 t
ORIGIN      
        1 atttctatag attaatattt tataaattta gtaaatgaat atttattata gtctttaaca
       61 aaaaatacaa gaataaactt aattttaata actaaaatta attatgcaaa attattaata
      121 tggtattaaa ttatgtataa aaagttaatt atgaataaaa taattatgcc tttgaaaaat
      181 cattaaactt aaaattaatt ataaaaaaac tctaccttac taactataca gctcacaatc
      241 tatctattta tgaaaaaata tgatataatt gcattcaaaa aggaaatctt tcaatatact
      301 agaatttaag cattaactaa ttttatctaa tattattact aaactaaaaa atatttgtat
      361 ttgtagcatt ggagcaagta acttaatgta tattcatttt aaatacttat ttaaaattta
      421 gcatttaaat tatttacaaa ttaacattta aatacttcta gcataaatac agttgtcatt
      481 aaaatttaaa gtatcttatg gaggaatacc atgcaaaatc ataattatat aaaaatgtta
      541 aataaaaagg tagaagtatt atctaaggaa ttagatagta gaaattttaa attaaaaacc
      601 ttaaatgaaa tagatttttt ttctaaaata ccaaacagag aatttatgta ccaacatatt
      661 gatgactgta tttcgaaaaa tatacatata ggaatcatgt tattaaatat cgataacttt
      721 aaattattta atgatatata tggataccta gtcggagaaa atttattaat tactctaact
      781 caaaacctat tgcactttat tccagaatca aagggaatag tcgcttattt aaaaggagaa
      841 ggttttttaa ttgtacttcc aaatgtatca aataaagagt taaataatat gggtgcaact
      901 attatagaga gcgcccgaga attaaaaata aaacttccta atgaaaaaga aatatactcc
      961 aatgttacat ttagtatcgg cagcactatc tggaatggtg aaccaaacat gactactttg
     1021 atgcttttca accaagtata tagtgcttta aaaaaggcta aaagtgaagg taaaaataga
     1081 tacattctat ttgattttaa agataatagt ttttacaata aattagaaaa tgataaggag
     1141 ttcttatcag aaatatcaca tgttctacaa actaaacaaa ttgaagtatt ttaccaacca
     1201 ctttataata taaaaaataa tactatagtt ggatgtgagg cacttgcaag atggagacac
     1261 cctattaaag gacttcttac tccagataaa tttattcctt tatttgaaca gtttggtctg
     1321 ataacggaat tagatttgca tttatttgaa gagaactgta aaaatataag aagatggatt
     1381 gataacaatg atgtttttgt tccaatttgt tgtaactttt ctcgtcttca tttttttaac
     1441 cctaattttc caagtatgct aaaaggtatt actgaaaagt acagcgtctc tacatcaaat
     1501 tttagcattg aaataacaga aaatatatta atagaaaata caaatacaat tattcaacaa
     1561 ctagctgaac ttcgttctta tggtttttct gtatcaatgg acgattttgg ttctggatat
     1621 tcatcttttg gtatgttgca aaatctacct tttgatataa tcaaaattga taggatattt
     1681 ttatctcata atttaaatga ttttaaaaat acaaccattt tgtactctat aataaacatt
     1741 gcaagagctc ttgggatgct tacagtatgt gaaggtgttg aaacagaaca acatgtagaa
     1801 tttattaaaa gtataaattg tgatatcgcc caaggttatt attatgcaaa acccatggag
     1861 tgcaaagaat ttgaaaaatt actatctaaa gagaataatt cagagaaaat gtttataaaa
     1921 tattctgata taggaaaatc tttaatagag aagatatttg atggattttt tattatgcaa
     1981 gatatgaaaa aactaagagc taatgtcact gaagacattc aatggtttga tttttacaac
     2041 aaaactgaaa ttacatcttt tcctaaagta atagagcatt ttgaaaaaca tattaaaggt
     2101 aaaaaatttt ctattcttta caaaagtata accccacata atactgaatc agattcatta
     2161 ttaattagtg gagaagccgt tttatcagat gaagcttctg aacatcaaaa atatagcaat
     2221 ttctacttta gtgcaaattg tataatttca gaaaataaat tactcttagc aaaattacat
     2281 ttggatttaa ttaaaactgc tggctatata aatgaatttg aatcatattc aatacctaaa
     2341 atgacaaata cacatcttga tgaaagtaat attttatcac aattttattc aatgttgcct
     2401 gtaggtataa ttcgctacga tttatttggt gatatgatta ttacttatat gaatgaagaa
     2461 atgtttgata ttataggtta tacaaaagaa cagttttttg gtgagatggg cggaaattta
     2521 agagcaattg ttcatccaga tgatttagac tttgtttata aaaaaagttt ggatatgatt
     2581 gacacaaata aaattgaacc atttttatat agattcataa aacgagatgg tcaaattgtc
     2641 acagttatgt atacacaatg taacctttct gcaattgatg gaaggtcgat tgcccagggt
     2701 atgtatgtag atgtaaataa aataaaaaat ttaacaaaaa tctagtacaa agtattttat
     2761 tttggagaaa ttaatatgtt taaagaaatt tttttaagaa cttttccagg atttctaatt
     2821 ataagagatt ctaactacag aattatattt ataaatgata atttaaaaaa tttaattaaa
     2881 agttatatgc aagataatcc acttggaatg actaatatag aaatagctaa gaaactccct
     2941 gataatattg ctaaattttt tacggattct cacaatattc aattagattg ggaaaaaaat
     3001 tatccttatg ataaaatttc aaattggatt ttagagttta aaaaagatac tacaagctat
     3061 tggaatgttt tagaatataa agtagatgtt gatgaaaaaa cctacataat tactatggcc
     3121 aatgatataa caaaactcta tgaagaaaat aagagaaatc ttcactactc aattactgac
     3181 ccattaactg gagcatataa tagaaaatat ttaaatgata gatttgacat atttatagga
     3241 gattatattg tactaattga cttagataat ttcaaaatga taaatgacta tgaaggtcat
     3301 aatgtaggag acaagatttt atgtgatttt gtttcacttt taaataaaga attaataaat
     3361 tctacttcta ttataagatt aggaggagat gaatttattg ttatattctc tagtgatgtt
     3421 gacaaaaatt atgtttattc acaactagaa gccttaagag aaaatttttt aaaagtattc
     3481 tctaagtata agtatctttc atttagttat ggtgttgata cagtaaaaag aaatttaaaa
     3541 ttgacaatag ttgaattgga taaaaaaatg tataaaaaca agaaaaaatt tgataaaaat
     3601 gattattaat attgttattt taaaataaat taaaattatc tttctttttt taaacttgta
     3661 cattagttta taaatatgta tctatacaag atattgacat taagtactga agcatatatt
     3721 gtttcagttc ttttttgtta aaattaactt atttaacaaa gatatcatag tttaacaaag
     3781 cttttaattt aaatatattg atgtataata taattaaaat ataatagcaa aaagaaagga
     3841 ggaatatcat gagcatactc ctaaaaaaag cacccaaatt agcaaaacat attataacaa
     3901 gtttttatat aaatcgggat attgatgaag tattaaaata cctttgtgaa aatgttacat
     3961 ggatcggacc aggagaacag gaatttctca cttcttttaa tgaaataaaa aattattttt
     4021 atgcaggtca agatgaaatt ccttcttgtg atataaataa tgatatattt gaaactgtaa
     4081 gtgaagatga gaatagatgt atggtattag gaagatatac tgttcgaact aaagaaaata
     4141 ctcaaatgat tttagaggta aatcaacgtt gtacatttga gataattgag gatagaggaa
     4201 aattattagt aaagcacatg cacatatcaa acccttatgg tgaaatgcaa cttgatgaat
     4261 actttcccac taaaattgga actcaaagtt atgattattt gcaaagatta ctaaaggaaa
     4321 aaacagaagt tattgaaatg attacaaata atatcaatgg tggcttaaaa ggtagcaatg
     4381 atgataatac atactcattt ttctatgtca atgaaggatt gcccaaaata ttaggataca
     4441 catatgatga gttcatggaa atgagtggtg gttcagcagt gggtgctgta tatccaccag
     4501 acttacctaa agcactagaa gattgtgaac gatgttttgc aaaaggacct acatattcat
     4561 ctgaatatag aatccgaaaa aaagatggaa cattaatgtg ggtattagat tctggaatga
     4621 aatcattaaa tagtgatggc atagtaaaaa ttaatagtat tattactgac ataacccaac
     4681 taaaaaacat agaatctgaa ctaaaattag aaagagagcg atatcgtatt gctttgcaaa
     4741 atattacaga tatcatgttt gagtatgata ttgaaaacga tacccttata aaatatcaac
     4801 gtgtagaaat tgacaaaaaa attgaattag aaaattttga aacaaaaaat tactccaaac
     4861 tattagaatc tggtaaaatt attcaccttg atgatattgg aaaactacta gaagtacttc
     4921 atggaaatct tcgtgaaaca attgagataa gacaagtaaa ttcattaact aaaaatgaat
     4981 ggagatggat tcgtgttcaa tgttcagtta tatatgatag tgaccataac cctatcaaaa
     5041 caataggcgt tttaaaagac ataactgaag ataaatctaa attagaaagc ttaattaatc
     5101 aggctcaacg tgacccacta acacaattat ataatcaaag agtatcacaa aatcttattg
     5161 aagagtatct atgtagttct gattccaaaa ataatgatgc tctattagtt attgatattg
     5221 atgattttaa aactgtaaat gatacttttg ggcatttaga gggaaatgaa gttttagttg
     5281 ctgtatcaaa aatactatta cataacacac atgataaaga catagttgct cgaattggtg
     5341 gagatgaatt tacaatattt ataaaatcat taacaaagga tttaataata aaaattacta
     5401 atgatatttt aaatgatgca agtaaaataa aagtaaagga caatcataaa ataacattaa
     5461 gtattggtat tgccttcact gatgattcaa ctaaattata taaagattta ttttctaaag
     5521 ctgataaagc tctttatcta tcaaaagcag atggcaaaaa ttgttatagt acatacgaat
     5581 aataaagcta tttatacgac caagaatgaa cctttaaatt taatttcata gtctaacaat
     5641 caaagagttg aagctaatct tatagctagt caactagttc ctagaaaaaa tttaaacaat
     5701 atatttattg atactgctca tttttctaaa gagcaaattt atataaaaaa ttaaactttt
     5761 atgtacatac agatactaat gataaacagt tatcattagt atcttctatc ttaaaacaaa
     5821 atgataattt atctatataa aaaagtgctt tgttgacaga gttcactttt ttatataggt
     5881 acagaattta agtataaata catgttttat tctatacatt ttagttaatg taaaatttct
     5941 tgattgtact ctctaacttt tcaacattat actatttata taccacttag ttaatataaa
     6001 ccccttagct ggttctagtg ctttttctat gattttagtc atatttacat accacttagt
     6061 taatataaaa ccaatttaga tgatgtatat gtgcaaaagg aagaaataat ttacatacca
     6121 cttagttaat ataaaacggt cactacaact tatacttcca gtctaacgat ttgaatttac
     6181 ataccactta gttaatataa aacatatttt ggatttatta atataaacat aattaaaaaa
     6241 tttacatacc acttagttaa tataaaaccc caaaataaac tgggcatttt caatacttac
     6301 acatatgcaa ctctcttaaa tttgcagtga accatgagta gtgcaaatga taaagcttat
     6361 catataccct caacacctta tatttcaagc gttaagctct actttgtaac aaatatcgct
     6421 cactgcaaaa ctatttacat ttttattata tcataaatat attatttttg aatatctata
     6481 ccaatttgtg gtataataaa agcaagaaga actacaatct atttagacgt agagtgaagt
     6541 tcaaatacta atgtttattc tttttgaact tgatttttag ttcaaaacta aagtcactcc
     6601 tgcctgtgtg aactataccc gctgttttat acagttaaaa catgtaaaaa tagttataaa
     6661 gtactagtgt aactcattag tactcttttt attatattca tataattaat atctatattt
     6721 taaagtttac tatctaaaaa agagcacgtc aaataaaacc ctagatattt aattttttta
     6781 gagatactta aaataaatta tgctctctct gtacttaaat atttcctaaa ttcaaatgga
     6841 gacatagaat ttaatctatt ttgatatcta aaattattat agtagtatat ataatcatct
     6901 attgctttaa ctaattattc atatgtatca aatttcctta aatagtacat ttctaccttt
     6961 aaaattcccc aaaatccttc cataggagca ttgtcaaggc aacgaccaac tcttgtataa
     7021 tatatgtata tctaacacca ttaagaaata tatattttat aatatatatt tcttcattta
     7081 atgcacttag aaaagcaaag aaaatacaga ttagtacact ttttagagaa aaataaaatt
     7141 aatacatcta aaatattaaa aaatacttta gataatctaa agacacatct caaagttttt
     7201 aactaaatta taaaactaat tacaaatgct atgtaacgat aataaataaa aaatttactt
     7261 cgcttaagcg acgtgtcgtt gaaatatttc atgttgccaa ctggttcgta agttgataag
     7321 aaaagaacac taattattta gagttctttt cttagctaca agtggattat aatactttta
     7381 aatctgtgag aaaatcatat ataataatga tatgaacaag taaagaaaat acaaaaatga
     7441 caaaattata aataaaatat tataaaatca taaggtcata attgttatat tgtagaaaca
     7501 aagtaaagag agagggtgga gaataaatga atcaaaaaaa aataaagatt agtattaaaa
     7561 tggtaattat aggtatattt gctgtaatta ttgcttttgt attatccaga ttattcgttg
     7621 agtatattga tgaattatta aggtctaatt ggcaatatca gctatttgaa agtgagagtt
     7681 catatatagt atttgccaat tgtattatgt tctcgaatat attattagaa atatttttaa
     7741 tatatatttg tagaaaattt agaaaaatct aatatggtca acgtatttcg aatcgaatac
     7801 ttcatgatta tttagtctat tgtgctagtt aaagtttaat tcccatataa agtaaattga
     7861 ttttagtaaa acaaatcacc cctaagggtt agtttatgga taagtcatcc aaatattaac
     7921 tctttaattt ttgctataga ttcatctttg ctcataactt tacttataaa aaatgaaata
     7981 ttataagcta gaacttttat tctaattcta gtcataaatc ctagcataga gttacttttt
     8041 ttatattata aataaaacta tacaacaaag ataatattta gtaaaaataa ctttcatttt
     8101 aactaaactt aaaattcaat tactctctaa attgacgttt aggaattagt tcaaaataaa
     8161 aaagagtgta tatattgaaa ttactacatt tcaatatata cactcttttt aaatttctca
     8221 gttttccatg gaactttact ttatttattt ctgtattagt tgtatttttt atgcattttt
     8281 ctttaaaatc atattttctg attcaactct tatattataa aatttcttta ctaaattatt
     8341 ctctttttct atatcttcat atatattttt taatcgcctt ttacctaatc ttttatctaa
     8401 cattactaat gatttaacta atatattata tgattttatc gcatcttcta ttgagatatt
     8461 taaacatata tttactgctt cataaaaatc aaattcatta aaaaatccat ttttatttac
     8521 aatcttatat ccctttgcat ctctttctaa atactcttcc taaatactct tcaaaacttt
     8581 catcatctaa tctaaatcct atatcactat gaaaaatagg ttttgcattt ggatatagtt
     8641 ctattgtttt atcaaaagtt tcgaatacca agttattatt attcgatttt ccaacagtcc
     8701 actataaaca ataataagtt tgttgctcca aataatgtaa cacttgtaga aagatgttac
     8761 agatatataa aagatagaga atgtagtttt tctcctaata ctattagaaa tagaaaaaat
     8821 atgattaaaa atcaaattga agttttcttt aaagatatga aattaataga tataactcct
     8881 tctattttac agtcttatat aaataacata tacaatgagc acatgttaaa ttcaacaaaa
     8941 aaccaagtcg attttataaa atcagtattg aaagaatctt atagattaaa agaaatatca
     9001 gaaaatattt gtgattttgt tacaacccca atcaaaaaaa atagttcaac ttctaagctt
     9061 tatacaaaac aaaaagctca attattatta gaaaaatcaa aaaatattcc tataggtata
     9121 ccaatttttt tgatgctaac tcttggatta cgttttggtg aagctgtatc acttatatgg
     9181 tcagatgtag accttgataa aaaatctcac atgtaaatca aacattagtt tatgtataca
     9241 ataaaataat cttcaaaggc cctaaaaccc ctagattcaa aagaagatta tttgttcctg
     9301 atgaacttat aagtttgttt aaaggggaaa aattaaaaca aaataagtta aaattacagg
     9361 gtatattgaa aaatgaattt gatttgatat gcttaaataa aagattcaac ccgtgagttc
     9421 aaccaacttt tgttgttcat tttaaaaaac tattaagaga taataatcct agagatataa
     9481 aagtacatga attaatacat gcaaatgcga ctttgatatt actttcaggt actaacataa
     9541 aagctattta taaaatatta gtacatgcag atataaaaat agctatgaat atatattcca
     9601 tattctcact tattagatga aatgaataaa gaaacatctg aaaatataag caaaatacta
     9661 ttcaaataat gttcagtttt atgtcaatta aatgtcactc aaagtgcttt ttttccattt
     9721 gtcagttaaa tgtcacttaa agtacctttt tcctatttgt cagttaaatg tcagtaatat
     9781 ataaataaga tatatttata agacccttaa aatcactatt atttaataaa atttataatt
     9841 atatactatt tg
//
LOCUS       DAEQCW010000122         9635 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.123, whole genome shotgun sequence.
ACCESSION   DAEQCW010000122 DAEQCW010000000
VERSION     DAEQCW010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9635)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9635)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9635
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.123"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(228..500)
                     /locus_tag="KRO40_003086"
     CDS             complement(228..500)
                     /locus_tag="KRO40_003086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093888.1"
                     /translation="MYDEIIEIYFDYWINEHMYRDILEKDKYYIESWKEVKKINELLE
                     KVLEDDKKYVLVELNDLFNSLIEFERELSYKLGFKTGAKFIIELMD"
     gene            complement(748..2082)
                     /locus_tag="KRO40_003087"
     CDS             complement(748..2082)
                     /locus_tag="KRO40_003087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2093889.1"
                     /translation="MNNSNNLIKNTEAEQSILGSILLDSTIVQELEQMLNEDMFYHEE
                     HKYIFNAIKEINKRNEVIDIITLTEELKRKGHLNNIGGISYITSLSTIVPTVSNFMSY
                     VSIVIEKYKNRNIIDKFKKFNLGEIDDNTLIYQLENDINKANQKLIKKDSSITAISER
                     AFEYINDEVNEGIKTGIKFLDDTIGGLYGGELTTIAAKSGRGKTALALQILRNVIFQG
                     KKVLFISGEMSDIQILFRNIASLTGISVVKMKNRNLNDEEIVKYIQALSIINQENNLY
                     INDSVNTISGIKREIKSIKPSLVIIDYLQILDYEGKEVGEAKFADLSRQIKKITLDFN
                     IPVIQLAQLNDELKDERPKGDRVMRSSKQIYMDSNSVIYIHRPTEKEALNYCKTMGIE
                     DIRELRRREKGFGANLSEIIVAKNRDGESGFRPYWYIGNLFSFEECKKIQEI"
     gene            complement(2095..2838)
                     /locus_tag="KRO40_003088"
     CDS             complement(2095..2838)
                     /locus_tag="KRO40_003088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093890.1"
                     /translation="MSNKGWIKLYRELLDKSIWKDIKPERKVILITLLLMASHKENHV
                     FIDNKRIKIKSGQFISSYSKIAERCGKGVSYQMVRSCLLVFKNAGFLTYETTNKYIVI
                     TIENWELYQENIENQQPNQQTINNQSTTIKNIKNENNIIYSEIISKFNSTCIELSKVK
                     KLTDTRKRRINSRIKEYDKETVLEVINIVSKTSFLNGNNNTGWKANFDWIMNSSNFTK
                     ILEGNYNSKEIVINKETGIYNPDDSQLKW"
     gene            complement(2860..3174)
                     /locus_tag="KRO40_003089"
     CDS             complement(2860..3174)
                     /locus_tag="KRO40_003089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093891.1"
                     /translation="MKENNNLEVLKTLQATLNIIVKNEEEAQEKKQGYKIIENAKRNK
                     AELITCKEASKLYPIGESKFRQLCHSKNKGFPCIWINNRVYIIKNKLDDWFIENANGI
                     KL"
     gene            complement(3178..3378)
                     /locus_tag="KRO40_003090"
     CDS             complement(3178..3378)
                     /locus_tag="KRO40_003090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093892.1"
                     /translation="MGINLKIFRIKKGLKQQELADRVGISRYYLSNLETGKANNPSND
                     LMIKLSRALDTTVEELFFSKED"
     gene            3525..4289
                     /locus_tag="KRO40_003091"
     CDS             3525..4289
                     /locus_tag="KRO40_003091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093893.1"
                     /translation="MQIGKNLKNIRKQKELTQIQLAEISGISRNALINYENDKRIPSI
                     DTLSKLAKALKIEKTIFYFDIENEVMTNEDVLYLLQSLFPEEYYSFDEFLNAISNLME
                     DDDIRITSSLLLGAWSDKDQYYKLGEKLELNENQVYNWILSDCISNTELDFSLHPDDI
                     KEIIKNDVLTKQSIDELLDIGLSEENIETIYDYFSDSTDNGSNIRLKKLISQKENITI
                     KNNDYFKLLQENNELKEKNEKLENTLKEIKKLLTKI"
     gene            4346..4544
                     /locus_tag="KRO40_003092"
                     /pseudo
     CDS             4346..4544
                     /locus_tag="KRO40_003092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729178.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            4541..5032
                     /locus_tag="KRO40_003093"
     CDS             4541..5032
                     /locus_tag="KRO40_003093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093894.1"
                     /translation="MMNNTIGEKIKQYRKSINMSRDELANKIGCSVHAIAKYEQNQRM
                     PSLDMIRKIATALSIAINKLIVEENDLDTLTNNNINLKVFDKELDLVIHILENYGYDI
                     KTDYKKKFEITDNADTIKPINLNFSDFKDFSKNLNWVINGLVENFIQENSNGLIEDED
                     EEY"
     gene            5124..5876
                     /locus_tag="KRO40_003094"
     CDS             5124..5876
                     /locus_tag="KRO40_003094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH2093895.1"
                     /translation="MNKSYIPKYTHKFPTNLPHGDKKYTLTYIRRMISEFVYDMGNLE
                     NNPFTFPEVQTLLDGITVGGHKLSDQNQILNIKSSWDYVIKLSNKENLSLNKDTICSI
                     HKIVAKDEALIVGDFRNGNIGIAGTTQYECIEATLLNDLFVNDINIINKITNPLEKAI
                     IINLWLSYCQFFYDGNKRTARLTSNLILISNDIGVLSIPAKHKQEYNTLMLNFYETLE
                     ADEVIKFLLEKCITFFDGYNYKSYKELFKNGN"
     gene            5866..7032
                     /locus_tag="KRO40_003095"
     CDS             5866..7032
                     /locus_tag="KRO40_003095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBH2093896.1"
                     /translation="MATKRANGEGSIGKYKDGWRSRIMIGYNEDGKPIRKEFYGKTQK
                     EVKDKLDAYKKQYYLSSDISDDKITLEHWFYNWLFEYRIKDLKPKSFERYESIYRNYI
                     KDTDLGNVKLKDLRVSHIQKYYNRLLDSNKSIPTIRQINTKLKTCLSEAEKQGLIQRN
                     YCTMVNIPVEKKENKLEILTLEQQKSFIKAIDGHKLEVLFLLALGTGLRLGELLGLKW
                     FDIDFKKSNLTVKRTLQRTYFIDKTGNRELKVLEQEPKTSNSYRTVPIPKDVLNKLKE
                     HKVNQNSDILKAGELYRNDNYVFCNELGIPIDDKRPLRNLKSILNSLDIEPIKFHGLR
                     KTYATRLFENDVPPKTVQVLMGHYDISITLNIYTQVMEDKKVEAVEKLDKIFSL"
     gene            complement(7148..7378)
                     /locus_tag="KRO40_003096"
     CDS             complement(7148..7378)
                     /locus_tag="KRO40_003096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093897.1"
                     /translation="MEANKTLLQILYKKIILEFSKQTGKSLEESMDYLYTSETYKLIS
                     EGVADMHCKGHIYLAQELMLENGLMYHKGYPR"
     gene            complement(7384..7863)
                     /locus_tag="KRO40_003097"
     CDS             complement(7384..7863)
                     /locus_tag="KRO40_003097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3990 domain-containing protein"
                     /protein_id="HBH2093898.1"
                     /translation="MIVYHGSYCVVKTPSITFSRDSLDFGKGFYVTSIKTQAINWTER
                     FKKRGKKAYLNSYSLDIDKLKENCKVKIFNSYNLEWLDFIIECRNMSDIYMKYDIIIG
                     GIADDKIYNTIELYQDNLIEKDEALKRLKYYKPNEQICITNQNVIDKYLKFRYEEEV"
     gene            complement(7863..8078)
                     /locus_tag="KRO40_003098"
     CDS             complement(7863..8078)
                     /locus_tag="KRO40_003098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3791 domain-containing protein"
                     /protein_id="HBH2093899.1"
                     /translation="MDERKLEFSIFCIEALAEKLNIDSEGVYKLLKHDTDILDNYIIP
                     CYEALHSQSKGYIVEDLMQVLKEKGVI"
     gene            complement(8394..8743)
                     /gene="ssrA"
                     /locus_tag="KRO40_003099"
     tmRNA           complement(8394..8743)
                     /gene="ssrA"
                     /locus_tag="KRO40_003099"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(8901..9356)
                     /gene="smpB"
                     /locus_tag="KRO40_003100"
     CDS             complement(8901..9356)
                     /gene="smpB"
                     /locus_tag="KRO40_003100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HBH2093900.1"
                     /translation="MAGKKILATNKRARHEYFIEETYECGIELKGTEVKSIRQGKVNL
                     SDGFASVDNSEVFLKQVHISPYEQGNIFNVDSLRVRKLLLHKHEIRKLIGATTIKGYS
                     LIPLSLYLKNGKVKVEIALAKGKKLYDKRQDMAKKDAQRRIEREMTGKY"
BASE COUNT         3443 a         1461 c         1083 g         3648 t
ORIGIN      
        1 tactccaact atacaaaact tatctaatat aattataatt ttgtatagta taaagagttg
       61 ataacatata aatattatag tgactatgat gaattcaaaa aaatcttaaa tttcaaatat
      121 aaaaatatat tgtatatagt atactaatat aatgctaaat taaaaaggac acttttaatg
      181 tcctctttaa tttagcatta tagaattaac ttataagcat aagtaaatta atccattaat
      241 tctattataa attttgctcc tgttttaaat cctaatttat aactaagttc cctttcaaac
      301 tctattaatg aattaaacaa atcatttaat tcaaccaaca catatttctt atcatcctcc
      361 aaaacttttt ctaataactc attaattttt ttaacctctt tccaactttc aatataatat
      421 ttgtcttttt ctaaaatatc tctatacata tgttcattta tccaataatc aaaatatatt
      481 tctataattt catcatacat tttagtacct ccttgacttt cctcaggcac ttaatatata
      541 cttaagttgc taggttagtg tacatcaagt acctaattta taaaggtagt tgttatattt
      601 atatggcaac tacctttttc taataagtgt ttaaatctaa actaaatata ttttaaatct
      661 ttattacatc taattaaaat ttatatttat acttcaacac ttcttgaaac ataatttatc
      721 tattacttaa taaatcatgc ttctttttta tatctcttgt atcttcttac attcttcaaa
      781 agaaaacaaa tttcctatat accaatatgg tctaaatcct gactcgccat ctctattttt
      841 agcaacaata atctcactta aattagcacc aaaacctttt tctcttcgtc tcaactctct
      901 tatatcctca attcccattg tcttacaata attaagagct tctttttctg taggtctatg
      961 aatatatata actgaattag aatccatata tatctgcttt gagcttctca tcactctatc
     1021 acctttaggt ctttcatctt tcaattcatc atttaattga gcaagctgaa taactggtat
     1081 attaaaatct aaagtaatct tttttatttg ccttgataag tcagcaaatt tagcttctcc
     1141 tacttcttta ccttcataat ccaaaatttg caaataatca attatgacta agctaggctt
     1201 aatactcttt atttctctct ttattcctga tattgtattt acagagtcat ttatataaag
     1261 attattttcc tgatttatta tgcttaaagc ttgtatatat ttgactattt cttcatcatt
     1321 tagatttcta tttttcatct ttacaactga tattccagtt agtgatgcta tatttctaaa
     1381 tagaatctgt atatcgctca tttctccact tataaaaagt actttcttac cttgaaatat
     1441 tacatttcta agtatttgta acgccaatgc tgttttacct cttccacttt tagctgctat
     1501 tgtagttagt tcacccccat ataaacctcc tatagtatca tctaagaact ttattccagt
     1561 tttaatacct tcatttactt catcatttat atattcaaag gctctctctg atatggctgt
     1621 tatacttgaa tcctttttta ttaatttctg attagcttta tttatatcat tttctaactg
     1681 atatataaga gtattatcat ctatttctcc aagattgaac tttttgaatt tatcaattat
     1741 atttctattt ttgtattttt caataactat acttacataa ctcatgaaat ttgatactgt
     1801 tggaactatt gttgacaaac tagtgatata gcttatacct ccaatattat tcaaatgacc
     1861 ttttctcttt aattcttctg taagagttat tatatctatt acttcatttc tcttatttat
     1921 ttcttttata gcattaaata tgtatttatg ttcctcatga taaaacatgt cttcatttaa
     1981 catttgctct aactcttgta ctattgttga atctaataaa atacttccta atattgattg
     2041 ctctgcttct gtatttttaa ttaagttgtt tgaattattt ataatataac ctccttacca
     2101 ctttaattgt gagtcatctg gattatatat tcctgtctct ttatttatga caatttcctt
     2161 gctattataa tttccctcta gtatcttagt aaaattactt gaattcatta tccaatcaaa
     2221 atttgctttc catcctgtat tattatttcc attcagaaaa cttgttttac taactatatt
     2281 tataacctct aatacagttt ctttatcata ttcttttatt cttgaattta ttctcctctt
     2341 tcttgtatct gttagtttct tgacctttga aagttcaata caagttgagt taaatttgct
     2401 tatgatttca ctatatataa tattattttc attctttata ttcttgattg ttgttgattg
     2461 attgttaata gtctgttgat taggttgttg attttctatg ttctcttgat aaagctccca
     2521 gttttcaata gttatgacta tatacttgtt tgttgtttcg tatgttagaa aaccagcatt
     2581 tttaaaaacc aacaaacaac ttctaaccat ttgataacta actcctttac cacatctttc
     2641 agctattttg ctataggaag aaataaattg tccagatttt atttttatcc ttttattatc
     2701 tataaaaaca tggttttctt tatgactagc cataagtaat agagttatta atattacttt
     2761 tctttctggt ttaatgtctt tccaaattga tttatccaac aactccctat aaagctttat
     2821 ccacccttta ttgctcaatt acaaacacct actttaaggc tataacttga taccatttgc
     2881 attttcaata aaccaatcat ctaatttatt ttttattatg tatactcgat tatttatcca
     2941 tatacaaggg aatcctttgt ttttagaatg acataactgc ctaaattttg attctcctat
     3001 aggataaagc ttagatgctt ctttacatgt tataagttca gctttatttc ttttcgcatt
     3061 ttcaataatt ttatatcctt gctttttttc ttgtgcttct tcttcattct ttacaataat
     3121 gtttaaagtg gcttgtaatg tctttaaaac ctctaaatta ttattctctt tcatatttta
     3181 atcctcctta ctaaaaaata attcttctac tgttgtatct aaagctctag atagtttaat
     3241 catcaaatca ttgcttggat tattagcctt acctgtttcc aagtttgata aataatatct
     3301 tgatatacca actctatctg ccagttcttg ttgctttaga ccttttttaa tcctaaatat
     3361 ttttaaattg attcccatac tttttcctcc ttttttctag tttacattcg taaactttac
     3421 attttaatta taatgtcgac atatgtgtac tgtaaataaa aatatattat ttttctgttc
     3481 tcatttgtgt acttttgggc tatactttat acgaggtgat aatattgcaa attggaaaaa
     3541 acttaaaaaa tataagaaaa caaaaagaac taacgcagat tcaacttgct gaaattagtg
     3601 gcatctcaag aaatgctcta ataaattatg aaaatgataa gagaatacct agtatagata
     3661 ccttatcaaa actcgctaaa gctttgaaaa ttgaaaagac tatcttttat tttgatattg
     3721 aaaatgaagt aatgactaat gaagatgttt tatacctttt acagtcttta ttcccagaag
     3781 aatactattc ttttgatgaa tttttaaatg ctatttcaaa tcttatggaa gatgatgata
     3841 ttagaattac ctcaagttta ttgctaggtg cctggtctga taaagaccaa tattataaac
     3901 ttggtgaaaa attagaacta aatgaaaatc aagtttataa ttggatactt tcagattgta
     3961 tatctaatac tgaattagat ttttcattac atcctgatga cataaaagaa attattaaaa
     4021 atgatgttct tacaaaacaa tcaattgatg aattattaga tattggtcta tcagaagaaa
     4081 atatagaaac aatctatgat tactttagtg actcaacaga taatggaagt aatattcgac
     4141 taaaaaaatt aatatctcaa aaagaaaata ttactattaa aaataatgat tactttaaat
     4201 tattacaaga aaataacgaa ctaaaggaaa aaaatgaaaa gcttgaaaat acacttaaag
     4261 aaataaaaaa actactaact aaaatataaa ataatatcaa tactatctaa agcaatgata
     4321 aaaaactatg aatggagtta caattatgaa taaatcatat atgctaaaat acacatataa
     4381 atgccctact aatttatttc atggagataa aaaatatact ctaacataca ctaagagagt
     4441 tatgagtaat ttagtatatg atatgggata atctagaaaa taactccttt acatgtttag
     4501 aagtacaatc attgtttgat gatatattta aggtgaaatt atgatgaata atacaattgg
     4561 agaaaagatt aaacaatata gaaaatcgat aaatatgtca agggatgagc tagccaacaa
     4621 gattggttgt tcagttcatg ctatagctaa atatgagcaa aatcaaagaa tgcctagttt
     4681 agatatgata agaaaaatag ctactgcttt atcaattgct ataaataaac tcattgttga
     4741 agaaaatgat ttagatactt taacaaataa taatattaat ttaaaagtat ttgataaaga
     4801 gttggattta gtaattcaca tattagaaaa ttatggttat gatataaaaa cagactataa
     4861 aaaaaagttt gaaattacag ataatgcaga tacaataaaa ccaattaacc taaacttctc
     4921 tgacttcaaa gacttctcca aaaatctaaa ttgggtgata aatggtcttg ttgaaaattt
     4981 tatacaagaa aactctaatg gtcttattga agatgaggat gaagaatatt agtattgcac
     5041 attttcaaaa tatgagttta cctattaact tttatacatt catagttaat aaataaaaat
     5101 tagatatgaa aggagctaaa atcatgaata aatcatatat accaaaatac acacataaat
     5161 tccctactaa tctacctcat ggagataaaa aatatacttt aacatacatt agaagaatga
     5221 taagtgaatt tgtatatgat atgggtaacc tagaaaataa cccctttaca ttcccagaag
     5281 tacaaacatt acttgatggt ataaccgtag gcggacataa attaagtgac caaaatcaaa
     5341 tactaaatat aaaatcatca tgggattatg taataaaatt aagtaacaaa gaaaacttat
     5401 ctttaaataa agatacaatt tgctctatac ataaaatagt tgcaaaagat gaagctctaa
     5461 tcgttggaga tttcagaaat ggtaatatag gtatagctgg tactactcaa tatgaatgca
     5521 tagaagccac tctattaaat gatttatttg taaatgacat aaatatcata aataaaataa
     5581 ctaacccctt agaaaaggct ataataataa atttatggtt atcctattgc caattcttct
     5641 atgatggcaa caaaagaact gctagactta cctcaaacct aatacttata agtaatgata
     5701 taggagttct atcaatacca gctaaacata aacaagaata caacacatta atgctaaact
     5761 tttatgaaac actagaagct gatgaagtta taaaattctt attagagaaa tgtattacat
     5821 tcttcgatgg atataactat aaatcatata aggagttgtt taaaaatggc aactaaaaga
     5881 gctaatggag aaggctctat cggaaaatat aaagatggtt ggcgttctcg tataatgatt
     5941 ggttataatg aagatggaaa accaataaga aaagaatttt atggtaaaac tcaaaaggaa
     6001 gttaaagata aacttgatgc ttataaaaaa caatattatc taagttctga tatttcagat
     6061 gataaaataa ctttagaaca ttggttttac aattggttat ttgaatatag aataaaagat
     6121 ttaaaaccaa agtcatttga aagatatgaa agcatctatc gtaattatat taaagatact
     6181 gatttaggca atgttaagtt aaaggactta agagtatctc acatacaaaa atattacaat
     6241 agattgcttg attccaataa aagtatacct actataaggc aaataaacac taaactgaaa
     6301 acctgcttat cagaagctga aaaacaaggt cttatacaac gtaattattg tactatggta
     6361 aatataccag ttgagaaaaa ggaaaataag cttgaaatat tgactcttga acaacaaaag
     6421 agttttataa aagctataga tggtcataaa ttagaggtat tatttttact tgctcttggt
     6481 actggactta gattaggaga attattagga cttaaatggt ttgatattga ttttaaaaag
     6541 tctaatttaa cagttaaaag aactcttcaa agaacatatt ttatagataa aactggaaat
     6601 agagagctta aagtattaga gcaagagcca aagacatcaa attcttacag aactgtacct
     6661 attccaaaag atgttttaaa taaattgaaa gagcataaag taaatcaaaa ttcggatata
     6721 ttaaaggctg gagaattata tagaaatgat aattatgtat tttgcaatga attaggtatc
     6781 cctatagatg ataaaagacc tttaaggaat ctaaagtcta tattaaacag tttagatata
     6841 gagcctataa agtttcatgg tcttagaaaa acttatgcta ctagactttt tgagaatgat
     6901 gttcctccta aaactgtaca agttttaatg ggccattatg atatatcaat aactttaaat
     6961 atatatactc aagttatgga agataagaag gttgaagctg tagaaaagtt ggataaaata
     7021 ttttcattgt aaaaatcaaa tacatataaa tattgtaatt tcatatagtt aattacaaaa
     7081 tcaaaataag gatacaaatt aattttatat tatcttgtat ccttatttcg tatctagttt
     7141 taattattta tcttggatag cctttatgat acattaatcc attttctaac attaattctt
     7201 gagccaagta tatatgaccc ttacagtgca tatctgccac accttcactt ataagtttat
     7261 atgtttcaga agtatataaa taatccatac tttcttccaa gctcttacct gtttgcttag
     7321 aaaattctaa tatgattttt ttatatagta tttgtaataa tgttttattt gcttccataa
     7381 tcactatacc tcctcttcat acctaaactt taaatattta tctattacat tttgattggt
     7441 tatacatatt tgttcatttg gtttatagta ttttaatctt tttaaagctt catctttttc
     7501 aataagatta tcctgataca gttctattgt attgtaaatc ttatcatcag caataccacc
     7561 tattataatg tcatatttca tatatatatc actcatattt ctacattcta ttataaaatc
     7621 aagccattct aaattataac tattgaagat ttttaccttg cagttttctt ttaatttatc
     7681 aatatctaaa gaataactat ttaaatatgc ttttttacct ctttttttaa aacgctctgt
     7741 ccagttaatt gcttgtgtct ttatactggt tacatagaat ccttttccaa aatctaaaga
     7801 atctcttgaa aaggtaatac taggagtctt taccacacaa tatgaaccat gatatacaat
     7861 cattatatca cacccttttc tttaagtact tgcattaaat cttccactat gtaaccttta
     7921 ctttgagaat gtagtgcttc atagcaaggt attatatagt tatctaaaat atcagtatca
     7981 tgtttaagaa gtttataaac tccttctgaa tctatattca atttttctgc taaagcttca
     8041 atgcaaaaaa tagaaaattc tagttttctt tcatccatta caaacctcaa ctcctatcaa
     8101 gcttatataa tatatatttt tactaattaa caacttaaac tatcttacat ttataaaaat
     8161 attatatcat aaagtagata ttaaaattct atgttaccta ttatcataat aaacaaataa
     8221 aataataaac aaataaaaac tttttataca acctaaatgc accccaatat acccccaaaa
     8281 aaacctcttt tcctgtggtt ggggtacggt tggtggattt tatctccaaa ataaaaaata
     8341 ctagtcaaca aagactagta tttccaagca tttcatcatt ctttttttaa aattggtgga
     8401 gacgagggga gtcgaacccc tgtccgcaaa tcttttcctt gctgcatcta catgcttagc
     8461 caacttcact aatatctcac ctcacatagc gccaagtggc aggctctatg cttagccagt
     8521 cccaattaat ctacttcaag tcgagacacc cctaaagtag ttccctgcat aatgacgtcc
     8581 agtcttagtc ggcaggagga ctaagaggga cgagcagcaa ctaggctgct atcgcgaaat
     8641 tatcgtctgc gtttatttta aagttcccca gtttttacgt gacccagagt aacacgacat
     8701 gcagcctcaa gttccaaacc cacgtcgaaa cctttacgcc cccttgagta gtttatagtc
     8761 cagtagactt ttcgcaaact ttatcaccat ttttattaaa tttttaatgt atatataata
     8821 taatactttt aagaataaaa atcaatgtta tgttctagat aataaagaat tttattctaa
     8881 aaaatacagt tttatctagt ttaatactta cctgtcattt ctctttctat acgtctttgt
     8941 gcatctttct tagccatatc ttgacgttta tcatatagtt ttttaccttt tgctaaggca
     9001 atctctactt taactttacc gttttttaga tacaaactaa gtggtataag tgaatacccc
     9061 tttatagtag ttgctccaat aagttttctt atttcatgct tatgaagtaa taattttcta
     9121 actcttaaag aatcaacatt gaatatattt ccttgctcat atggacttat atgaacttgt
     9181 tttaaaaata cttcgctatt atctacagat gcaaatccat cacttaggtt aactttgcct
     9241 tgtcttattg attttacttc tgttcctttt aattcaattc cacattcata agtttcttct
     9301 ataaaatatt catgtcttgc tcttttgttt gttgctaata tttttttacc agccatataa
     9361 atctcacctt ctttgctaga aatttcttcc ataaatgtta gaaatttact aaatatttaa
     9421 tgttgccaaa ttatttgact aacttgtatg ataacatatt taggcatttt agtcaatatt
     9481 tcactgatat attaagttag ttaggctata tataattaag taatataaat gtatgaaaat
     9541 agctaaaaaa ctacttcgaa tatacttaat actaaactaa ctctaaccag taatactaat
     9601 ttataaattt caaaacaaaa atattacata ttata
//
LOCUS       DAEQCW010000123         9588 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.124, whole genome shotgun sequence.
ACCESSION   DAEQCW010000123 DAEQCW010000000
VERSION     DAEQCW010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9588)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9588)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9588
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.124"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            297..1232
                     /locus_tag="KRO40_003101"
     CDS             297..1232
                     /locus_tag="KRO40_003101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HBH2093901.1"
                     /translation="MIRYYKTIDSKLEKLSFFEDGCWINLVEPNHSEINEISNLLNID
                     VESIESALDEEERSRIDVEDNHTLILIDIPVDESDSNSSHYTTIPLGIILTEEAIVTV
                     CDAQTKILNDFIVGHIKDFFTFKKTRFLLQILHKNAAYYLHYLRKINKMTIIIEREIY
                     KSMKNKELVQLLELEKSLVYFSTSLKSNELVLNKMVRTAGIKKYPDDEDLLEDVIVEN
                     RQALDMAKIYGDILSRIMDAFSAIISNNQNNVMQILTVVTLIFSIPTIISGFFGMNVI
                     NMPFSNNPNGFWIILLITSIICIVITFFMSRNKLL"
     gene            complement(1324..3195)
                     /locus_tag="KRO40_003102"
     CDS             complement(1324..3195)
                     /locus_tag="KRO40_003102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sel1 repeat family protein"
                     /protein_id="HBH2093902.1"
                     /translation="MKNTKFSIKKIKNISNDPKVVHTKGALLEKMGKMESAIELYKSA
                     ALDNYVKSQYTLGNIYESKKQFKEAEKWYSMAYKSGSEDAAFDLGNMYYKLDGYEYAI
                     YWYEKIANLGYLQAQNNLGVCHFKMKDFVRCEKWLKTAADKNLGKACFNLGVLYTFLE
                     KDDEAYEYYKKGSVLLDDDAKYNLAILNGKKKDNKSTVSLYKQLYKSGHMKGCFNLGM
                     IMEINDNLEDAEKYYKKSADRDDVKSEYRLAYVYDRKEELGDAIYYYEKAIEKNHTLS
                     KYRLANLYNRENEIEKAKTYYKMAAEDDITEAKNNLAGIYFEEKDYENAIKYYEDAIA
                     VGCKSSLENLGDLYYQNQDIEKAISYYSRIPNNVSCQIKLGNIYEDLNNIEEAISWYK
                     KASENGDTRSSYRLGCIYESLGNTKNARKYFEMASSKNHMNARIHLGRIYFREGKLEE
                     SKMMFDTPANENNVYAQHMVGLIYDMFYKDYVNSKFWYEKARAQGCVESIYNLGQIYL
                     KLNDDAEAEKYYKEGIKYGSKKCEYMLAGLYYKKSLDMYISLANEEYDNCEEIVEGFP
                     NLNIDFDEVLIPPFKLQEEVIDEEEYVPIYILNIKESLDSMLEGLETEMIIDEEHDS"
     gene            3385..4311
                     /locus_tag="KRO40_003103"
     CDS             3385..4311
                     /locus_tag="KRO40_003103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBH2093903.1"
                     /translation="MNFSNIFIQVAVLFIIILVGYFVRKFNLLDDHCTSKLSTLTMTV
                     FLPSMIISSMQINFDSKMIQKILLLLFTSLIMYIVSIIIAFLLKYILKCNDKKDLGIY
                     QYIVVFSNVAFMGYPVIEAVLGHEAIFYTAIFNLPFNLFSFTLGIYLLSKGSTSRGFS
                     IKSLISPATIAIVIGLFLFVTGLRLPQFINEPLEMLGSITTPISMIIIGSLLANSSAL
                     DCFVNKKLYIVTFIRLLVLPVIVYFILKGWINDKMILAIPVVISSMPAAANTAIMANQ
                     YDSNITLASQCVFFTTLFSVISIPFISILLLS"
     gene            4450..4596
                     /locus_tag="KRO40_003104"
     CDS             4450..4596
                     /locus_tag="KRO40_003104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093904.1"
                     /translation="MDMDLLFKIVFAIVAIGVSVKIIKTVASLAFKIALILLIILFVY
                     RMFL"
     gene            complement(4701..5225)
                     /locus_tag="KRO40_003105"
     CDS             complement(4701..5225)
                     /locus_tag="KRO40_003105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2093905.1"
                     /translation="MSKPIDITIRPIRREDAQAFNEIRRTYSVMRNTLALMSDRVDKT
                     EAMLASLGENDYMFVAETNNNGEKDVIGFAGLHVNSSPRLRHSAEIGISVAENYQGRG
                     VGKKLMEQLLDIADNWIMLTRVGLEVIVDNEKGLNLYKKLGFEIEGTKKYAVIRDGKF
                     EDVYIMGRYNKNLI"
     gene            complement(5278..5502)
                     /locus_tag="KRO40_003106"
     CDS             complement(5278..5502)
                     /locus_tag="KRO40_003106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093906.1"
                     /translation="MIIKLTKDNFNFRFKQYEGMFFHAEVVEGMESIRYKITKDKEGT
                     ELKEFGSTHIKDNMIYVPQVEAYIDLNSIK"
     gene            5699..6823
                     /locus_tag="KRO40_003107"
     CDS             5699..6823
                     /locus_tag="KRO40_003107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3810 domain-containing protein"
                     /protein_id="HBH2093907.1"
                     /translation="MSKKTKYFSLILFPIALLLNFIASKVPNIVEKYYSQFIDKIIVQ
                     ILSKVSGIFPFSLYEITMYIIVISIFLFLCCTLSTIFNKKKKLNIYLKNSILNILSIV
                     SIVYFLFVVLWGINYNRIPLETTLINNYNLKNNTSIQSKQYSVKELTKLYKFLVIKAN
                     ETRKLTLQDKNGIVKSNTDYNGVINRAQLGYDNILDILPGVSGSYSKPKYIISSNLMC
                     YTGITGIYFPFTGEANVNIAIPDLYIPCTVEHEMAHQRGFASEDEANFIAYLTSIKHP
                     NIDFNYSGYILALNYTASALSKVDYNAYVDISAGISDSVRRDLKNESEFWQKYEGKIN
                     EISNEFNNSYLKANSVTEGTQSYGKMVDLLLTYYELYPYN"
     gene            complement(7297..8121)
                     /locus_tag="KRO40_003108"
     CDS             complement(7297..8121)
                     /locus_tag="KRO40_003108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093908.1"
                     /translation="MRYKKISSLPILVVALLITGTTTTFSLSTTNSEKTNVYLANTVS
                     TVTKKVSDIQSSKGLVYNENIPLFINNSKIQYDDTPYHWPSNVISLTNSSEKAIMDYE
                     ITCLAYDKNGKPLELYWDAQNVAADGEVGSVGFSPAGVDYGIVTGISPVSPKSYSHTY
                     RKMQQSPPQDIISMFEKQQGKAWVENWLKEWKQMEKEYAKQNAIAPGKNQNDAFLLFD
                     KWKQSTGEHGVKYIISCVKQVTFNDGSVWKNSAYENWLKSFQGKEVSNSVLENYYK"
     gene            complement(8469..9524)
                     /gene="ispG"
                     /locus_tag="KRO40_003109"
                     /gene_synonym="gcpE"
     CDS             complement(8469..9524)
                     /gene="ispG"
                     /locus_tag="KRO40_003109"
                     /gene_synonym="gcpE"
                     /EC_number="1.17.7.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="HBH2093909.1"
                     /translation="MSYERRKTREVSVGTVKIGGENPISIQSMTNTDTRDADATIAQI
                     KRLEEAGCDIVRVAVPDIKAAKNIAKIKSSVNIPIIADIHFDYKLALEAIEQGVDGIR
                     INPGNIGSIERVKMVVEKCKERNLKIRIGVNGGSLEKELLKKYGSATAEALVESAMGH
                     IKILEDLDFHNIVISLKSSDIYKTVDAYELISKKVDYPLHIGITESGSVHKGTIKSSI
                     GVGALLLKGIGDTVRISLTGDPVEEVIVGKQILRSLGLLNDKIKVISCPTCGRCNIDL
                     ISVVNEVEEKIGSMEKNITVAIMGCAVNGPGEAREADIGIAGGKGEGLLFKKGEIVRM
                     IDGNKLVDELLEEIEKL"
BASE COUNT         3232 a         1564 c         1004 g         3788 t
ORIGIN      
        1 ttatggtaaa aatattattt aatcaaatca aaacttgatt tatatacctg gaaaaggtat
       61 tatattaaag agtgcttaaa atacgcattt cataaatagc tatatataaa ataataaata
      121 aggagagtga tgggcaatgg atactagtcc gttgcggaga gaatttttta cattttcatc
      181 acttaataat atctaaaatc aaaactaata catatattca gttatataaa ttagttaatt
      241 aatagatact attaaatgat gagatttata taaaactgaa taaaggatgt gttgccatga
      301 taagatatta caaaactata gattcaaaat tagagaaact tagttttttt gaagatggct
      361 gttggataaa tcttgttgaa cctaatcata gtgaaatcaa cgaaatttct aatttattaa
      421 atatagatgt agaaagcata gaatctgcac tagatgaaga agaacgctca agaatagatg
      481 ttgaagacaa tcatactctt atacttatag atataccagt agacgaaagt gactctaatt
      541 cttctcatta tactacaata cccttaggta ttatactaac tgaagaagct attgtaacag
      601 tttgtgatgc acaaactaag attttaaatg actttatagt tggtcatatt aaagattttt
      661 ttacatttaa aaagactcgc tttttgcttc aaattcttca caaaaatgca gcttattact
      721 tgcattactt aagaaaaata aataaaatga caataataat agagcgagaa atttacaaat
      781 caatgaaaaa caaagaattg gttcaattat tggaattaga aaaatctttg gtatacttct
      841 ctacctcact aaaatctaat gaacttgttt taaacaaaat ggttagaact gctggtataa
      901 agaagtatcc agatgatgaa gacctattag aagatgttat agttgaaaat agacaggctc
      961 ttgatatggc taaaatatat ggagatatat tgagtagaat tatggatgct ttcagtgcaa
     1021 ttataagtaa taatcagaat aatgttatgc aaattttaac agtagttaca ctaattttct
     1081 caatacctac aataatatca ggattctttg gtatgaatgt catcaacatg ccattttcta
     1141 ataacccaaa cggattttgg ataatacttc ttattacctc tataatatgt atagtgatta
     1201 catttttcat gtcaagaaat aagctattat aaaatattaa taaaaaagcc attagaatta
     1261 attgatttac atttatccta atggctttta tatatttaaa tctatataat cttataatac
     1321 tttttaacta tcatgttctt catctataat catttcagtt tcaagccctt ctagcattga
     1381 atctaaactt tcttttatat ttagtatata aattggtaca tactcttctt catctattac
     1441 ctcttcttgc aacttaaatg gaggaattaa tacttcatca aagtctatat ttaaatttgg
     1501 aaagccttct actatctctt cacaattatc gtactcttca tttgctaaag aaatgtacat
     1561 atctaggctc tttttataat aaagacctgc aagcatatac tcacacttct tacttccata
     1621 tttaatacct tctttataat atttctcagc ttctgcgtca tcatttaatt ttaaataaat
     1681 ttgacctaaa ttatatattg attcaacaca accttgtgct ctagcctttt cataccaaaa
     1741 tttagaattt acataatctt tatagaacat atcataaatt aatcctacca tatgttgagc
     1801 atacacatta ttttcattgg caggtgtatc aaacatcatt ttagactctt ccaatttacc
     1861 ttctctaaaa taaattctac ctagatgtat acgagcattc atatggtttt tgctacttgc
     1921 catttcaaaa tactttctag cattttttgt atttcctaag ctctcatata tacaccccaa
     1981 tctataacta gacctcgtat ctccattttc agatgctttc ttataccaac ttattgcttc
     2041 ttcaatatta tttaaatctt catagatatt tcctaatttg atttgacaag atacattatt
     2101 tggaatcctc gaataatacg aaatcgcttt ttctatatct tgattctgat aatataaatc
     2161 ccctagattt tcaagggaac ttttgcatcc aacagctata gcatcctcat aatatttaat
     2221 agcattttca taatcttttt cttcaaaata tatacctgcc agattatttt ttgcttctgt
     2281 tatatcatct tcagcagcca ttttataata agtttttgcc ttctctatct cattttctct
     2341 attatataaa ttagcaagtc tatacttaga aagtgtatga tttttttcta ttgctttctc
     2401 ataataataa attgcatctc ccagctcttc ttttctatca tatacatatg caagcctata
     2461 ctcagacttc acatcatctc tatcagcact ctttttataa tacttctctg catcttctaa
     2521 attatcattt atttccataa tcatacccaa gttaaagcaa cctttcatat gacctgactt
     2581 gtacaactgt ttatataaac ttactgttga tttattatct ttcttttttc catttaatat
     2641 tgctaaatta tattttgcat catcatctaa aagcacagaa ccttttttat agtattcata
     2701 tgcttcatca tctttctcca aaaaagtata taatacccct aaattaaaac aagctttacc
     2761 taaattcttg tctgctgctg tttttaacca tttttcacac cttacaaaat ctttcatttt
     2821 aaaatggcat acacctaaat tattttgtgc ttgtaaataa cctaaatttg ctatcttttc
     2881 ataccaatat atagcatatt catagccatc taacttatag tacatattac ctaaatcaaa
     2941 agcagcatct tcacttccac ttttatatgc cattgaatac cacttttctg cttctttaaa
     3001 ttgtttttta ctttcatata tatttcctaa agtatattga gattttacgt aattatccaa
     3061 tgcagcactc ttatacaact ctattgcgct ttccatctta cccatctttt caaggagggc
     3121 acccttagta tgtacgactt tcgggtcatt agatatattt tttatttttt ttatagaaaa
     3181 ttttgtattt ttcattattc gctacctacc cattttataa aatatattct ctcaaacatt
     3241 attatacatt ataatctaca attaatgcta taatattgaa tttttacctt ttgtcactat
     3301 attgtaacat taaattttaa attttataat cattagattt tattatgtaa ttggtatata
     3361 atgtatatat aggggggaca ttttatgaat ttcagcaata tttttatcca agttgcagtt
     3421 ttatttataa ttattttagt tggatatttt gtcagaaaat tcaacttatt agatgaccac
     3481 tgcacatcta agctttcaac tttgacaatg acagtttttt taccatcaat gataattagc
     3541 tccatgcaaa ttaactttga tagtaaaatg atacaaaaaa tactattgtt attatttaca
     3601 tctttgatta tgtatatagt ttcaattata attgcatttt tattgaaata cattttaaaa
     3661 tgtaatgata aaaaagattt gggaatatac cagtatatag ttgttttttc aaatgttgct
     3721 tttatgggtt atcctgtaat tgaagcagtt ttaggtcatg aagcaatatt ctatactgca
     3781 atattcaatt tgccttttaa cttattttct ttcactttag gaatttatct tttatctaaa
     3841 ggcagtacaa gtagaggttt ttcaataaaa tcacttataa gccctgctac aatagctatt
     3901 gttattggac tttttttatt tgtaacagga cttaggttac cccaatttat aaacgagcca
     3961 cttgagatgt tgggaagtat aactacacca atatccatga ttatcattgg aagcttactt
     4021 gctaattctt cagctctcga ttgttttgtc aacaaaaaat tatatatagt cacttttata
     4081 agattattgg tacttcctgt gattgtgtat tttattctaa aaggatggat aaatgataag
     4141 atgattttag ctataccagt agtaatttct tcaatgcctg ctgctgcaaa tactgctata
     4201 atggctaatc aatatgactc caatataaca ctagcttcac aatgtgtgtt ttttacaaca
     4261 ctattttcag ttatatctat accttttata agtattttac tcttatcttg atttattttt
     4321 ttatgtatta tataataaca tattcaataa attacaaata taaacatttt attgtagtat
     4381 attgatggaa ttttttccta gatatttgtc aataatatct atatgtatta tagaatagga
     4441 ggcttaaata tggatatgga tttactcttt aaaatagtat ttgctatagt tgctataggt
     4501 gtttctgtaa aaatcattaa aactgttgct agtttagctt ttaaaatagc gttgatattg
     4561 ctaataattt tatttgtata tagaatgttt ttgtaaacat ttaaaaataa gttttttaac
     4621 acaatagaga agtaaaatag attatcttta atgtaaattt tttattaaag acactctatt
     4681 ttacttctct attagcttat ttaaattaaa tttttattat atcttcccat aatataaaca
     4741 tcttcaaatt ttccatctct gattacagca tattttttag ttccctctat ttcaaaacct
     4801 agctttttat ataaatttaa tcccttttca ttatccacaa ttacttctaa tcctactcta
     4861 gttaacataa tccaattatc tgctatatct aaaagttgtt ccataagctt cttacctact
     4921 cctcttccct gataattctc tgcaacactt attcctattt ctgcgctatg tctcaatcgt
     4981 ggagaagaat ttacatgtaa cccagcaaaa cctattacat ctttttctcc attattatta
     5041 gtttcagcta caaacatata atcattttct cccaaagaag ctaacatagc ttcagtttta
     5101 tcgactctgt cactcattaa tgccaaagta tttctcataa cactgtatgt tcttctaatt
     5161 tcattaaaag cttgtgcatc ttctcttctt ataggtctta ttgttatatc tataggctta
     5221 ctcatattgg attccccctc aaacataatc tttattttta attaaaattt tacatcttta
     5281 ttttatactg ttcaaatcta tgtatgcttc tacctgaggt acatatatca tattatcttt
     5341 tatatgtgta cttccaaatt cttttaattc tgtaccttct ttatccttag ttattttata
     5401 tctaatggat tccatacctt caactacttc agcatgaaaa aacatacctt catattgttt
     5461 aaatctaaaa ttaaaattgt ctttagtaag ttttattatc atatttttat ctactcctta
     5521 tataattgat atttttctta ttattagttg tatatatact gcttattcat attaatatat
     5581 tataacttat catttattta gtataaagtt ataaatagat atatttatac ttattttaca
     5641 atctttcttc aattgatata taatatgttt atataaacta atgtatgtga ggtgaaatat
     5701 gagcaaaaaa acaaaatatt tttctttaat tctctttcct attgctttgc ttttaaattt
     5761 tatagccagc aaagttccaa atattgttga aaaatattac tcccaattca tagataaaat
     5821 aattgtacaa atattgagta aagtttctgg aattttccca ttttctctct atgagattac
     5881 aatgtacata atagttatat ctatcttctt atttttatgt tgtactttat ctacaatttt
     5941 taataagaaa aaaaaattaa acatatattt aaaaaattcc attttaaata tattatccat
     6001 tgtatcaata gtctactttc tttttgtagt gctttgggga ataaactata ataggattcc
     6061 actagaaacc acacttataa ataactataa tttaaaaaac aatacctcta tccaatcaaa
     6121 acaatatagt gttaaagagc ttactaaatt atataaattc cttgtaatta aagcaaatga
     6181 aactagaaaa ctcacattac aagataaaaa tggtattgta aaatctaata cagattataa
     6241 tggtgtcata aatagagctc aactaggata cgataatatc ttggatatat tacctggtgt
     6301 tagtggtagt tattctaagc ctaagtatat tatttcatca aatctaatgt gctatacagg
     6361 aataactggt atatactttc cttttacagg tgaggcaaat gtaaatatag caatacctga
     6421 cttatatatt ccttgtacag ttgaacatga aatggcacat caaaggggat ttgctagtga
     6481 agatgaggct aattttatag cgtatcttac ttctataaaa caccccaata ttgattttaa
     6541 ctattctgga tatattttag ctttaaatta tactgcttct gctttaagta aggttgatta
     6601 taatgcatat gttgatattt ctgctggcat ttcagattct gtccgtagag atttaaaaaa
     6661 tgaaagtgaa ttttggcaaa aatatgaagg taaaattaat gaaatttcta atgagtttaa
     6721 caattcttac ttaaaagcta atagcgttac tgaaggtact cagagttatg gtaaaatggt
     6781 tgatttattg ctaacttatt atgaattata tccatataac taaacactac aattcaaaat
     6841 tttattcata tacagctgat attaaatcag ctgttttcta tttaaataaa ttatttaact
     6901 tcaagcaatc ttatataatt tgatagtact tatactatct gtataacatt tcaattctaa
     6961 ctattttagt taaaacattt ctattatctt ttttaataaa tgttttaact aaaattttta
     7021 aaacataaaa cttccacatt atttcactat ctatataaaa atctaaaaat tcacatataa
     7081 aattacataa ctaaaaaatc ataaatttat agaaaacata tattcaaaat aaaaaagcat
     7141 gtatcaaaac ttgacacatg cttataatct tatgtatata tatcattttg tcacaataaa
     7201 aatttacttg taacactgat atttttaaac aaaatagtcc ttatttaatt aaattaacat
     7261 taattaaatt cgtactcatt ttgctatcat taaacattac ttatagtaat tttctaatac
     7321 actatttgaa acttccttcc cttgaaaact tttcaaccaa ttctcatatg ctgagttttt
     7381 ccatacacta ccatcattaa atgttacttg ttttacacaa gatataatgt actttacacc
     7441 atgctctcca gttgattgtt tccatttatc aaacaataga aaggcatcat tttgattctt
     7501 acctggtgct attgcatttt gctttgcata ttctttctcc atttgtttcc attctttcaa
     7561 ccaattttct acccatgcct tgccttgttg tttttcaaac atacttatta tatcctgtgg
     7621 tggtgattgt tgcatttttc tataagtatg tgaatatgat tttggagaca caggagatat
     7681 gcctgtaaca ataccatagt ctacaccagc tgggctaaat ccaacacttc ctacttcgcc
     7741 atctgctgcc acattttgag catcccaata tagctcaagt ggttttccat ttttatcata
     7801 tgctaagcat gtaatttcat aatccataat tgccttttca ctgctatttg ttaagcttat
     7861 aacattgcta ggccaatgat atggagtatc atcatactgt attttgctat tatttataaa
     7921 taatggaata ttctcattat aaacaagacc tttactactt tgaatatctg ataccttctt
     7981 tgtgacagta cttaccgtat ttgctaagta tacatttgtt ttttctgaat tggtcgtact
     8041 aagagaaaat gttgttgtcg ttccagtaat cagcaaagca acaactaaaa taggtaagct
     8101 agatattttt ttatatctca caattcttca cctctttttc tattaactta taataaaaca
     8161 atttaccaaa acattaaaat ctatgttaac ataatttacc aactgttcta gtaactatat
     8221 cctatcatag ttactatcaa gtttcaatac tattgatgga aattttcact atattaaatc
     8281 tttttttaat tttataaatt tacaatatga tttaactcat acatatatag tcaaattaga
     8341 atataagttt cttacattta atgaagttta taaaataaaa aatgactaga taattaaata
     8401 ctgtaaataa aaacttatta caaaagtatt taaaaatcta gtcaattaat atatatatga
     8461 attgtatact ataatttttc aatctcttct agcaactcat caactaattt gttaccatca
     8521 atcattctaa ctatttcacc ctttttaaat aaaagacctt cacctttacc cccagcaata
     8581 cctatatctg cctctctggc ttcaccaggt ccatttacag cacagcccat aattgcaaca
     8641 gtgatatttt tttccatact accaatcttt tcttcaacct catttacaac actaattaag
     8701 tctatattac atctaccaca tgtagggcat gatataactt taatcttatc atttaaaagt
     8761 cccaaacttc ttaaaatctg tttaccaaca ataacctctt caacagggtc gcctgttaaa
     8821 gatattctaa cagtatctcc aattccttta agaagaagtg ctcctacccc tatagaagac
     8881 tttattgttc ctttgtgaac acttccagat tctgtaattc caatatgaag aggataatca
     8941 actttttttg atattaattc atatgcatca acagttttat aaatatcgga tgattttaga
     9001 gatataacta tattatgaaa atctaagtct tcaagaatct taatatgtcc cattgcactt
     9061 tcaactaatg cttcagcagt tgcagagcca tactttttta aaagttcttt ctctaaagaa
     9121 cctccattaa ctccaattct aatttttaaa tttctttcct tgcatttctc aactaccatc
     9181 ttaactctct ctatacttcc aatattacca ggatttattc ttattccatc cacaccttgt
     9241 tctatagctt caagggctag cttataatcg aaatgtatat ctgcaataat tggtatattt
     9301 acactagact ttatctttgc tatattttta gcagctttaa tatcaggaac agcaactcta
     9361 actatatcac aaccagcttc ctctaatctc tttatttgag ctattgtagc atctgcatct
     9421 cttgtatcag tatttgtcat agattgtata cttataggat tttctcctcc tatttttaca
     9481 gttcctacac ttacttctct cgtctttctt ctctcgtaac tcatattcca cctctatata
     9541 ttattttata ttgaatctct ttaaatatta aaatattata acctacat
//
LOCUS       DAEQCW010000124         9485 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.125, whole genome shotgun sequence.
ACCESSION   DAEQCW010000124 DAEQCW010000000
VERSION     DAEQCW010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9485)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9485)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9485
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.125"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            295..699
                     /locus_tag="KRO40_003110"
     CDS             295..699
                     /locus_tag="KRO40_003110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication/maintenance protein RepL"
                     /protein_id="HBH2093910.1"
                     /translation="MDKTLKKDLNQEYTESKSLVMNKSKYMNVCFKNYIKVVEGMYTK
                     RDLIPLKLINSMDKNNKIRKTLYELSCEFEYPKTSLSSLFTELKKMDFLQRVKNGEYM
                     INPHIAYKGSRADKESLLAEYNQIKRPNKVSK"
     gene            716..1312
                     /locus_tag="KRO40_003111"
     CDS             716..1312
                     /locus_tag="KRO40_003111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093911.1"
                     /translation="MSLKLDRNVLQWFDYVFENEKTSLRHYNFNCTLKEISSTSLNKV
                     AFILEKNNSKYWKLYFEIPAEVTLKLKQNIHPLFREYIYEQISLYNNNQIYNFVNSNI
                     LKVFNNIAIYQYNILENLYTIDFKKSFIDKCQYLLIGEKRLIDEDLYLIAKSKEVFDF
                     FNSDGTFNLTLSFDIQKNENLLDSLLELRKSIIINERI"
     gene            1349..3943
                     /gene="clpB"
                     /locus_tag="KRO40_003112"
     CDS             1349..3943
                     /gene="clpB"
                     /locus_tag="KRO40_003112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent chaperone ClpB"
                     /protein_id="HBH2093912.1"
                     /translation="MDVEKMTLRVQKSLNEAYNEAVKNHNQQVDVIHLFSALINQEDG
                     LIPNIIEKMNISIDSLRNTVNFEIDKLPKVYGEGADSQGVSATRKINEVLIKAESISK
                     EFKDSYISVEHVMLAMMETESKSAVGKILKQYNINKNDFLNILSQVRGSQRVETQDPE
                     GTYDALARYGTNLVDLAKKNKLDPVIGRDEEIRRIIRILSRRTKNNPVLIGEPGVGKT
                     AIVEGLAERIVRGDVPEGLKDKIVFSLDMGALIAGAKYRGEFEERLKAVLKEVQSSDG
                     KIILFIDEIHTIVGAGKTEGSMDAGNLIKPMLARGELNCIGATTFDEYRKYIEKDKAL
                     ERRFQPVIAEEPTVEDTISILRGLKERFEIHHGVRIHDNAIVAAAKLSHRYIQDRFLP
                     DKAIDLIDEAGAMIRSEIDSLPTELDVVRRKLFTLETEREALLKENDDKSKSRLDDIQ
                     KEIAELKSKNDEMTAKYEKEKSQILDIKNLKAQLDEAKGKAEKYEREYDFNKAAEVKY
                     GEIPKLEEQIKQYEENMNDGSENSLLKEEVTEEEISSIVSKWTGIPVTKLVEGEREKL
                     LKLEDELHKRVIGQDEAVTAVSNAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKT
                     LARNLFDSEDNIIRIDMSEYMEKHAVSRLVGPPPGYVGYEEGGQLTEAVRRAPYSVIL
                     FDEIEKAHEDVFNMFLQILDDGRLTDNKGKTVDFKNTLIIMTSNIGSNYLLEAGGNIT
                     ETTNNLVMNEMKHRFKPEFLNRVDDIIMFKPLDQENIKKIIDIFMKDLKNRLKEKDIT
                     IEVTNSAKDVMVREGYDPVYGARPLKRYIGNTLETIIAKKLIAGDVYNGCTIVIDGKD
                     ENIEVLVK"
     gene            complement(4139..5566)
                     /locus_tag="KRO40_003113"
     CDS             complement(4139..5566)
                     /locus_tag="KRO40_003113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093913.1"
                     /translation="MTNSFKKDDNRKKITVLFVVIAMTFMATLDSSIINVALPVLASK
                     LNVSLASIEWVIASYSIIICSTLLFFGRLGDIIGKSRVFQVGTILFTSASLLCGLSNS
                     LTLLIVCRFIQGIGASAYMANNHGIITELFPKESRGKALGILVTAVAIGNMVGPSVGG
                     FILSIFDWNVIFFINIPIGLIVIFLNTKFLPNSKKSSENMDKTGAILQFLGTTLFFSA
                     LISAQQTGLLNPYILIALLLSIIFIILFLILEKKHPQPLLDLEIFRNFKFSLNLICAL
                     TSFICIASSSILIPFYLQSTMKLPPIQAGLFMILSPLILAIFSPIFGNISDKIKSEKI
                     ILIGLLVMSFGFFLMSRLKESSALILFVIYISIISIGQAIFQPANNALIMSSCSRSKL
                     GVVGSINSLVRNLGQVIGITISTTLLYNFMSIKAGYRVNDYVINNDKIFVFGMRNVYI
                     IVTLVCLIGAILIGFYLFKYNKNEQ"
     gene            5707..6603
                     /locus_tag="KRO40_003114"
     CDS             5707..6603
                     /locus_tag="KRO40_003114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBH2093914.1"
                     /translation="MKDKNTYFNRKGQENFIDIFLKDDIKKGANFKRHWHEHLQIYYF
                     IDGIAYLECGLDNFKVVPGNIVIANSNELHYLESLSDNLKFYSIRIEPTFLFSNQVDL
                     LQTKYLAPLALNHIVFNNLIQNDSLILKCITTILDEYHNKEVGYELSIKANIYQLIVL
                     LLRSHIDKIYSEDEFIKRKYSLEKFECIFDLIEEKYMDKITLKELASRVNLSAHHFCR
                     TFKQITGKTTIDFINGIRIDKAIYYLKETDLNMTEIAMRCGFDSINYFSRLFKRNYNI
                     SPTKYRNEHREVSNVILKEDMK"
     gene            7268..7408
                     /locus_tag="KRO40_003115"
     CDS             7268..7408
                     /locus_tag="KRO40_003115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093915.1"
                     /translation="MEKSNTTVTKKEKIEDIGMKLEHLLSEDITFYELLLEILYKEKE
                     EN"
     gene            complement(7405..7776)
                     /locus_tag="KRO40_003116"
     CDS             complement(7405..7776)
                     /locus_tag="KRO40_003116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093916.1"
                     /translation="MESLGDRIANLRKELDINQKELATKVGITEASLSRYENNLREPK
                     SEIIVRLAKALETSTDYLLGVNDNTKISKEDKLIIENLSVSEKTKKLLEKIYSLEKED
                     REAIEKMIDNAYLKRFLKEEN"
     gene            8325..8582
                     /locus_tag="KRO40_003117"
     CDS             8325..8582
                     /locus_tag="KRO40_003117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093917.1"
                     /translation="MIIIRSQDKTNLMQINQIKIDGSQVYAVFESKIDTVKIGDYENN
                     TRAIQVLDNIQNFIENGTKYDYITSNKVRYNVNKIFQMPAK"
     gene            complement(8692..9372)
                     /locus_tag="KRO40_003118"
     CDS             complement(8692..9372)
                     /locus_tag="KRO40_003118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBH2093918.1"
                     /translation="MIWTFYSFICVILPCLIYQIVVIKRKNLKVEKNVMIHLVWVYIF
                     LLYIYLALSKAGIGSIWDIGRYSGLFRIDEINLIPFDSVGILTYILNIIMFMPLGFLL
                     PLIWKNFRNIINVSLTGLGFSLAIELCQLFNLRATDIDDLMMDTLGAVLGYLIWVGVN
                     NLFNLIKKKDIFPSIYKNIIQDEIAITIDDDISEKITSLYKNEAIIYLILAVLGEFLL
                     FNWSIIPY"
BASE COUNT         3922 a         1007 c         1389 g         3167 t
ORIGIN      
        1 tttagaaaaa actaattgcc aatattatac atttaataaa tgtaatgtat tttatgaaag
       61 tctgccatat taaatagata taaatttttt taaaaaattt ataaatattg ttcaaaaatc
      121 ctgccaataa attggaaata ctaaattaaa aaaataataa agtttagctt atagctaaat
      181 aaaagtttac ttataaggta aactttttgc atttttagtt ttgacataca tatttttttg
      241 taatatattt atattatcaa ttagagataa ggagagtgag aagagatatt taatttggat
      301 aagacattaa aaaaggattt aaatcaggaa tatacagaga gcaaaagttt agttatgaat
      361 aaaagtaagt atatgaatgt ttgttttaag aattatatta aagtagtaga aggaatgtat
      421 actaagaggg atttaattcc attaaaatta ataaactcta tggataaaaa taataagatt
      481 agaaaaacat tatatgaatt atcttgtgaa tttgaatatc caaaaacttc tttatcttca
      541 ttgtttacgg agctgaaaaa aatggatttt ttacaaagag tgaaaaatgg tgagtatatg
      601 ataaatccac atatagcata taaaggtagt agagctgata aagaaagttt attagcagaa
      661 tataatcaga taaaaagacc taataaggtt agtaaataag gaagaaggtt tttatatgag
      721 tttaaaactt gatagaaatg ttctacagtg gtttgactat gtatttgaga atgaaaaaac
      781 tagtttgaga cactataatt ttaattgtac actaaaggag attagttcta ccagtttgaa
      841 caaagtagct tttattttag aaaaaaataa ctctaagtac tggaagcttt attttgaaat
      901 accagctgaa gttactttaa aacttaagca aaacattcat cctttattta gggaatatat
      961 atacgaacaa atatcactgt ataacaataa tcaaatttac aattttgtaa attcaaacat
     1021 attaaaagtg tttaataata ttgctattta tcaatataat attttagaaa atctatacac
     1081 tattgatttt aaaaagagtt ttatagataa atgtcagtat ttattaatag gtgaaaaaag
     1141 acttatagat gaagacttgt atttaatagc aaaatcaaaa gaagtattcg atttttttaa
     1201 ttcagatgga acatttaatt taacattgag tttcgatata caaaaaaacg agaatttact
     1261 tgatagtctt ttagagctta gaaaatcaat aattataaat gagagaattt aatttatttg
     1321 gatataatat taaaatggag ggatttatat ggacgtagaa aaaatgactt taagagttca
     1381 aaaaagttta aatgaggctt ataacgaagc agtaaaaaat cataaccaac aagtagatgt
     1441 aattcatctt ttctcagcac ttattaatca agaggatgga ttgataccaa atataatcga
     1501 aaaaatgaat atatcaattg attctttgag aaatactgta aactttgaaa ttgataagct
     1561 tccaaaagta tatggagaag gtgctgactc acaaggagta tcagctacta gaaaaataaa
     1621 tgaggtgctt ataaaggcag agagtatttc taaagaattt aaagattcat atataagtgt
     1681 agagcatgtt atgcttgcaa tgatggaaac agaatcaaaa tcagctgttg gtaaaatatt
     1741 aaaacaatat aatataaata agaatgactt tttaaatatt ttatcacaag tgagaggtag
     1801 tcaaagagta gaaacacaag acccagaagg cacatatgat gcacttgcta gatatggaac
     1861 aaacttagta gatttagcca agaaaaataa attagaccct gtaattggga gagatgaaga
     1921 aataagaagg attataagaa ttttatcaag aagaacaaaa aataatcctg tattgattgg
     1981 tgagccaggt gtaggtaaaa ctgcaattgt agaagggtta gcagagagaa tagtaagagg
     2041 agacgtccca gaaggtttaa aagataagat tgtattctca cttgatatgg gagctttaat
     2101 tgctggtgca aaatatagag gtgaatttga agaaagatta aaggcagttt taaaagaagt
     2161 tcaaagttct gatggaaaaa ttatactgtt tatagatgag attcatacta ttgttggagc
     2221 tggtaaaaca gaaggttcaa tggatgcagg taatcttatt aaacctatgc ttgcaagagg
     2281 tgaattgaac tgtattggtg caactacttt tgatgaatat agaaagtata tagaaaaaga
     2341 taaggctctt gaaagacgtt ttcagcctgt aattgcagaa gaacctactg ttgaagatac
     2401 aatatctata cttagaggtt taaaagaaag atttgagata catcatggag taagaataca
     2461 tgataatgct attgtagcag cagcaaaact ttctcataga tatatacaag atagattttt
     2521 accagataaa gcaattgatt taattgatga agctggagct atgattcgta gtgaaataga
     2581 ttcattgcca acagaattag atgttgttag aagaaagtta tttacattag aaactgaaag
     2641 agaagcatta cttaaagaaa atgatgataa aagtaaatca agattggatg atattcaaaa
     2701 agaaatagca gagttaaaat ctaaaaatga tgaaatgaca gcaaaatatg aaaaagaaaa
     2761 gagtcaaata ttagatatta aaaacttaaa ggctcaatta gacgaagcta aaggtaaagc
     2821 tgaaaagtat gaaagagaat atgatttcaa caaagcagca gaggttaaat atggtgaaat
     2881 acctaagtta gaagaacaaa taaagcagta cgaagaaaat atgaatgatg gttctgaaaa
     2941 ttctctttta aaagaagaag ttactgaaga agaaatatct agcattgtat caaaatggac
     3001 aggtatacca gtaactaaac tagttgaagg agaaagagaa aaattactta aactagaaga
     3061 tgaacttcat aaaagagtta ttggacaaga tgaagcagtt acagcagttt caaatgcagt
     3121 aatacgtgca agagcaggat taaaagatga aagaaaacca attggttcat ttattttctt
     3181 aggccctaca ggtgttggta aaactgaact tgcaaaaact cttgctagaa atttattcga
     3241 tagtgaagat aatataataa gaatagatat gtctgaatac atggaaaaac atgctgtatc
     3301 aagactagtt ggacctcctc cagggtacgt gggatatgaa gagggtggtc aacttacaga
     3361 agcagttaga cgtgctcctt attctgtaat actatttgat gagatagaaa aagcacatga
     3421 ggatgtattt aacatgttct tacagatatt agatgatggt agacttactg ataataaagg
     3481 taagacagta gactttaaaa atactcttat aataatgact tctaatatag gaagtaatta
     3541 tctattagaa gcaggaggaa atataacaga gactactaac aatttagtaa tgaatgaaat
     3601 gaagcataga tttaaacctg agtttttaaa cagagtagat gatattataa tgtttaagcc
     3661 tttagaccaa gaaaatatca agaaaatcat agatatattt atgaaagatt taaaaaatag
     3721 attaaaagaa aaagatatta ctattgaagt tacaaattca gcaaaagatg ttatggtgag
     3781 agaaggatat gaccctgtat atggagcaag acctcttaag agatatatag gaaatacatt
     3841 agaaactata attgcaaaga aacttattgc tggagatgtg tataatggat gtactatagt
     3901 tatagatgga aaagatgaaa atattgaagt tttagttaaa taataaaaga atcagttgag
     3961 cataatatac taaatatttt gctcagctga tttttattta taaactatag gaaaagaaat
     4021 attttatcaa attaataaaa catttttaag tcaatatgtc caaattaaat ttaactcaaa
     4081 ggaagtattt tagtaaattt cttataatat aatcataatt tgaatataat tataaaaact
     4141 attgttcatt tttattatat ttaaataaat aaaagccaat taatattgca cctattaagc
     4201 aaacaagtgt aacaataata taaacatttc tcattccaaa tacaaatatt ttatcattat
     4261 taatcacata atcattgacc ctatatccag ctttaatact cataaaatta tataaaagtg
     4321 ttgtagaaat agtaatacct ataacttgtc ctaaatttct tacaagggaa tttatgcttc
     4381 ctacaactcc tagcttactt ctagaacagc ttgacattat caaagcattg ttagcaggtt
     4441 gaaatatagc ttgtcctatt gatattatcg atatataaat tacaaataaa ataagggcag
     4501 aactttcttt caatcttgac attagaaaga atccaaaact cataacgaga agaccaatta
     4561 aaataatttt ttctgactta attttatctg atatattccc aaatataggt gaaaaaatgg
     4621 ctaaaatcaa aggtgatagt atcataaata aacctgcttg aataggggga agtttcatag
     4681 tactttgtaa ataaaatgga attaaaatac ttgatgatgc aatacaaatg aatgatgtaa
     4741 gagcacaaat taaattcaat gaaaatttaa aatttctaaa aatttcaagg tcaagaagcg
     4801 gttgaggatg ttttttttct aatatcaaaa ataatataat aaaaataatt gataataata
     4861 gtgcaattaa tatatatgga tttagtaatc ctgtttgttg agcactaatt agagcactaa
     4921 aaaataatgt tgttcctaaa aattgaagta tagcaccagt tttatccata ttttctgaag
     4981 attttttact attaggaaga aattttgtat ttaaaaagat tacaataaga ccgattggaa
     5041 tatttataaa aaatataaca ttccaatcaa atattgacaa aataaatcct cccacagatg
     5101 gtccaaccat atttccaata gcaactgcag taactagaat ccctagggct tttcctctgc
     5161 tttcttttgg aaatagttct gtgataattc catgattgtt tgccatgtag gcagaagcgc
     5221 ctattccttg aataaagcgg caaactataa gtaaagttaa agaattactt aatccacata
     5281 gtaatgaagc tgatgtaaag agaatagtac ctacttgaaa tactcttgat ttaccaataa
     5341 tatctccaag tcttccaaaa aataatagtg ttgaacaaat aataattgag taacttgcta
     5401 ttacccattc aatagatgct agagatacat ttagtttgct tgcaagaact gggagagcaa
     5461 catttataat actagaatct aatgttgcca taaaagtcat ggcaatgact acaaataaaa
     5521 ctgtgatttt ttttctatta tcatcttttt taaaagagtt tgtcattttt attacctcct
     5581 tattataatg actgcattat gttaatgttt acaatgatag ttacatttta tataatagcg
     5641 atatgaaata atgaatacaa taactatatt gcttataatt agcactattt tgctgagggg
     5701 ggaataatga aggataaaaa tacatatttt aacaggaaag gtcaagaaaa ctttatagat
     5761 atatttttaa aggatgacat taaaaaagga gcaaacttta aaagacattg gcatgagcat
     5821 ctacaaatat attattttat tgatggtata gcatatcttg aatgtggatt ggataatttt
     5881 aaggtagtgc ctggaaatat tgtaatagca aacagtaatg aattacatta tttagaaagc
     5941 ttatcagata atttaaaatt ctatagtatt cgtattgaac ccacattcct ttttagtaat
     6001 caagttgatt tgttacaaac caagtactta gcaccattgg ctttaaatca tattgtattt
     6061 aataatttaa ttcaaaatga ttctctgatt ttaaaatgta ttacaactat acttgatgaa
     6121 tatcacaata aagaagttgg atatgagtta tctataaaag ctaatatcta tcaattaata
     6181 gtactcttat taagaagtca tattgataaa atatattctg aagatgaatt tataaaaaga
     6241 aagtattctt tagaaaaatt tgaatgtatc tttgatttga tagaagaaaa atatatggat
     6301 aaaattacat taaaagaact tgctagtcgt gtgaacttga gtgcacatca cttttgtaga
     6361 acatttaagc aaataacagg taagactaca atcgatttta taaatggaat caggattgat
     6421 aaagctatat attatttaaa ggaaacagat ttaaatatga cagaaattgc tatgagatgt
     6481 ggctttgata gcataaatta ttttagtcgc ttatttaaaa ggaattataa tatatctcca
     6541 actaagtata gaaatgaaca tagagaagtt agtaatgtta ttttaaaaga agatatgaaa
     6601 taatccataa atatacttta tagaaaatat atatttttaa atctttgagt ttttcttaat
     6661 aaatattaat aaagtatagt acataaatga gtaagactac ttgtatagtt aaatgtgaaa
     6721 atgagtatga aagaatgcag tgtctatgaa aagtatattt taatatgaaa ctaaaactgg
     6781 aaaaataaga atagcagaaa aaatgattat attataaatc agtttttttg agacatctgg
     6841 cttagattct gaaagatatt taatcaaaga aataaaacta ttaaataagc aagtaaacag
     6901 ctaaaatagt atgattttta tagaaaattt aaatccatcc taaagaatta aaagaaagtc
     6961 aaataaatat aaaaaaatta tatatttata aaaaatttta taataaaaat catcctgaaa
     7021 aatatataaa aatagaaaaa acatacaaga ttctacaata atagattttt ttgttattat
     7081 tacgagtttt ttattgcaac tgtagaataa aagtattatt atataattaa gataattatc
     7141 tagggaaatt ttggataatc aaaatatatt ttataaaatc aaaatacaat tacataaact
     7201 ttattaaaaa tttgttggga atttctgact aacattaaga acgtaagttt gttgggggat
     7261 ggtatatgtg gaaaagtcaa acactactgt tacaaaaaaa gaaaaaattg aagatatagg
     7321 aatgaaatta gaacatttat tgagtgaaga tattactttt tatgaattat tacttgagat
     7381 tttgtataaa gaaaaagaag agaattaatt ctcttcttta aggaatcttt ttaaataggc
     7441 attatcaatc attttttcta tagcttctct atcttctttt tcaagagaat atattttttc
     7501 taagagcttt tttgtttttt cacttactga taagttctct atgattaatt tatcttcttt
     7561 gcttattttt gtattatcat ttacgcctaa taaataatct gttgatgttt ctaatgcttt
     7621 tgctaatcta actattattt cacttttagg ttctcttaaa ttattttcat aacgtgacaa
     7681 gctagcctca gttataccga ctttagtagc aagttctttt tgatttatat ctaattcttt
     7741 tcgtagattt gctattctat ctcctaaact ttccatatgt acatcactcc ttaccgaaat
     7801 tataagttat tttgataaaa agtaaaataa aattaccaaa aatataaaaa aaaaaggtta
     7861 aaataataaa atatattgaa aattaccatt tgtatatgta taatatgaat tatacaaatg
     7921 gtaatttgat gagaggtggt atgttgaaat aagaaactga attaattaat aaatacatag
     7981 aaagttttga aaacctttaa ttgagatata aacaatatgt acaaaatttt ttgcaagtaa
     8041 aattaccaaa tgtataaaat aaatcagtag catagataat tttatgcttt aatacattag
     8101 attatttaat ttagttataa tggtcaaaaa tgcaatctac aaataaaaca aagtattatc
     8161 caaaaagtat tctttaagaa aattttttat tagagatgta attgatataa ataatcgtat
     8221 taaaaaataa aatactaagt ttaaaaattt aaataatcta taaatcaatt ataaaatatt
     8281 atttcttaga aattaaaatg aattaagtaa atggaggaat tgatatgata ataatcagaa
     8341 gtcaagataa aactaattta atgcagataa accaaattaa aatagatggt agtcaagttt
     8401 atgcagtatt tgaaagtaaa attgatactg taaaaatagg agattatgaa aataatacaa
     8461 gagctataca agtgttggac aatatacaaa acttcattga aaatggaaca aaatatgatt
     8521 atataacatc aaataaagtc agatacaatg ttaataaaat atttcagatg ccagctaaat
     8581 agtgagtgtg cattttaatt taataactaa agcccacttt cttttgtagt atgaaagagg
     8641 gctttacata tttgtaaata tcgaagtaca cttgttttat caataaatta tttaataagg
     8701 tataatggac caattaaaca ataaaaattc tcctaaaaca gcaagtatta aatatataat
     8761 agcttcattt ttgtaaagag aggtaatttt ttcgcttatg tcatcatcaa ttgtaatagc
     8821 aatttcatct tgaataatat ttttatatat agatgggaaa atatcttttt tctttataag
     8881 attaaataaa ttatttacac ctacccatat caaatatcct aaaacagcac ctaatgtgtc
     8941 catcattaaa tcatcaatat ctgtagctct taagttaaac aattgacaaa gttcaattgc
     9001 taatgaaaaa cctaatccag ttaatgaaac attgataata tttctaaaat ttttccaaat
     9061 taaaggtagt aaaaatccta aaggcataaa cataattata tttaaaatat atgttaagat
     9121 gccaactgag tcaaaaggta ttagatttat ttcatcaatt ctaaaaagcc cactatacct
     9181 tcctatatcc catatgctac caattccagc tttactaagt gctagataga tatataataa
     9241 aaaaatatat acccatacta aatgtatcat tacattcttt tcaactttca aattttttcg
     9301 ttttataacg actatttggt atattaagca tggtaatata acgcaaataa atgaataaaa
     9361 tgtccatatc attttatttt gtcccctttc aaatttatgt ttttagtttt ataagtacta
     9421 tctttatatt aaactgtaag ttttaaaaat cttttaataa aatcttaaaa atttattaat
     9481 ttata
//
LOCUS       DAEQCW010000125         9224 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.126, whole genome shotgun sequence.
ACCESSION   DAEQCW010000125 DAEQCW010000000
VERSION     DAEQCW010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9224
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.126"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(262..2328)
                     /locus_tag="KRO40_003119"
     CDS             complement(262..2328)
                     /locus_tag="KRO40_003119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBH2093919.1"
                     /translation="MVELIITTNIDIRKLNENQLEAVEHIDGPCMILAGPGSGKTRVI
                     TYRIANMVVNKNIAPTRILAISFTKASSIEMKNRALNLSDDIRLNKVTYGTFHSVFFK
                     ILRYFERYNLDSIFDEKSKRMTIKAILKSLNIENADDDENIGQVINEISYVKNELMDK
                     NEFNSEVLTKDEFLKVYNLYEEQKSKVNKIDFDDMLIRTYYLLLNNKSALEMVRNVYK
                     YILIDEFQDINKVQFEVLKLICSPLNNIFAVGDEDQSIYGFRGARPDFLLEFEQYFNN
                     TKKIILDINYRSKSEIVHTANRLIDKNKNRYEKIIKCSQGDGGSVTYISPHDSEEEAL
                     YIAREIIDEIQKDYVEYSDFAVIYRTNIQSRALVDVFMDMRIPFVVKDSVITIYDHWA
                     SQDILAYLRIGINPKSNKDWLRIINKPFRYISKDSINMVKDEKDFITALINKCNLHPK
                     QVKTINDLEIDLSYLNTLNPKNAISYIRTSLDYDRYVLDYCSNRKIKTNGLVEILNEL
                     ESSATNFNTVTEFLEHIDRVKTELTENNKNKQTEGVIFTTMHSAKGLEFRNVYIIGVN
                     EGTIPHEKSYDICKEEKKEEQLEEERRLMYVAITRAEEKLCISSTLNKYGKKVDKSLF
                     INDIKSPTKKEIDSIGVGDKVYHKKFHEGEIIKKDGIMFTIKFKDRERILDLKTCLLK
                     NIIYTI"
     gene            complement(2405..5434)
                     /locus_tag="KRO40_003120"
     CDS             complement(2405..5434)
                     /locus_tag="KRO40_003120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2093920.1"
                     /translation="MENNLRKNNSIMKKMIFPLIIVMLIQTSLFCATILWGGTIKKLN
                     DNSFDILNERVINRKNYIQNEMLQRWSNTSETEATINSSVKKVLNEKNALIEDVGNNE
                     EINKDIIKSISNDLIYLLRKNSVTGAFIILSDKNINDKSIDSKGEISRTGLYIRDLDP
                     KFNPNDNSDLLIERGSSDIARSFGISMDSYWEPKFSFKSENEQDGDDFFYKPFRAAID
                     NPNVSSSNLGYWGSKFLLTNAGDRLMTYTVPLIYEDGTVYGVLGIDLSVNYLRELLPY
                     SEINGNKKGNYILGVDRNNDMAFENVISNGYSLKEKFWDGLHSNLEQKESYKNIYKIK
                     NKDNECGNGNIYASVQYLDLYNSNTPFENERWALLGIIEEKSLLSFSKRVEKLVIISI
                     AISLLIGLIGIYIASRLFTKPIVLLANKVRNSNPSKPVNLDKINISEIDELSSAIELL
                     SANVADSSSKLSQIIEMVDMPIGAFELYKNAENVFCTKEFFSVFTTEIKFEEYGYMEK
                     NKFLKKLRGLDKYLQESYETENTYIYKFESKDKKLKWIRMNIFEDELKVLGVVVDVTK
                     EFIEKRKIEYERDFDILTNLLNRRAFHSQIQEKFKNKDELKIAAFIMWDLDNLKYIND
                     TYGHDAGDEYIRCAADILKKFISWNGIVSRLSGDEFYVFIYGYESKDSIRDIINSVKK
                     QMNNTLLKLHDGTEFKIRASAGISWYPDDSTNYDELMRYADFAMYQIKNTIKGEVSEF
                     DINIYNKDSFLLSNREELNKLIDGQLVEYAFQPIVDCKGKVFAYEALMRPKIKTFSSP
                     IDVIRLARSQSKLYQIERITWFKALKSFKKYKEKFGDCKLFLNSIPNNNLSKVDFEEI
                     EDLYGEYLNRVVLEITENDKINEDFIEKKKAYIDHWNIEIALDDFGTGYNGDAVLLYI
                     MPDYVKIDMSIVRGIDKDENRQKILKNLISYSNERNIKVIAEGVETKGEMETLINLGV
                     DYMQGYYISKPSFIPEDISDKIKKELKICHENRNDVV"
     gene            complement(5487..6947)
                     /locus_tag="KRO40_003121"
     CDS             complement(5487..6947)
                     /locus_tag="KRO40_003121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HBH2093921.1"
                     /translation="MNRCKFAKLIITSMIVLLLTGCSLKKEDNYKLDPENPTSIQIWH
                     YYNGQQKMAFDKLVKEFNDTVGAEKGIIVEAFSQGNVVDLSEKVLDSANKKVGSEDVP
                     NIFAAYSDTAYEMDKLGLLVDMDKYISKEELNEYIDEYVEEGRINSKDEFKLFPIAKS
                     TEILMLNKTDWDKFAKATNSNINDIKTIEGLVETSKKYYEWTDSLTKEPNDGKAFFGR
                     DALANYIIIGSKQLGVEIFSVKDGKVTLNIDEKVMKKLWDNFYVPYINGYFASYGKFR
                     SDDAKTGDILALVGSSSGAAYFPDRVMLNDNESYNIETSVFQAPRFKGEGKYAVQQGA
                     GMAVTKSTKEEEYASVEFLKWFTDKEPNIKFSIASGYLPVKKKTNDLDVIKEVMKKDN
                     LSLSDKVEGSIASSIEQINSCNLYTNKAFDGGTKARQILEYSMLDKAKEDSNKINELV
                     KSGTSKKDAVAQFNNDKNFKTWFESFKAELENAIKK"
     gene            complement(7039..7413)
                     /locus_tag="KRO40_003122"
     CDS             complement(7039..7413)
                     /locus_tag="KRO40_003122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093922.1"
                     /translation="MGNKNKNTKYKDKTRERYNKKVENLNKEKLNKVNKQSKKVDKID
                     DIINKSSIVLCVLLVVFSLLYLFKLVQLNIIMILLVITVAIQQGLVSFGAFRNKNYVK
                     ALFSIFVIVCFLIAFKYVVNPV"
     gene            complement(7589..8329)
                     /locus_tag="KRO40_003123"
     CDS             complement(7589..8329)
                     /locus_tag="KRO40_003123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBH2093923.1"
                     /translation="MLYDEDEKEENNERWLLTYSDLITLLMIFFVIMYSMSNVDAEKY
                     KQLSQSLNSAFGGSSGVIEGGNSKIEPVVEPGSNDLDTLQNAKFKKVGEEIQKYLNEN
                     GMANSVSLRVQDRGLVISLKDTILFDTGKAIVKDNSRDKIIQIGKMLNEMNSYMRVEG
                     HTDNMSIKNSEFKSNWDLSVMRATNVVQLLIDNAGIAPDKLSAVGYGEFRPIAENSSE
                     EGRSKNRRVDIVLVDSKYDNVENVSKDK"
     gene            complement(8350..9138)
                     /locus_tag="KRO40_003124"
     CDS             complement(8350..9138)
                     /locus_tag="KRO40_003124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor protein"
                     /protein_id="HBH2093924.1"
                     /translation="MTTLIFFIVGIASLVVAFVIDGGHVGALFVFSSALVVFGGTIGA
                     VGASTPFPVFKKSIKIMLLAFKNKKPNNIENIIYFKEIATKARKEGLLSIDKEISEND
                     ELDPFIRKGLELMVDGVDAVTIRNILESQIQITSKRHKEGIAIFDSAGGYAPTLGIIG
                     TVMGLVHILGNLSSNPDALGPQISVAFLATLYGVGSANLIWLPIASKLKAINQQEISE
                     RLLVIEAILSILEGDNSNLMTEKLKIFLNSKELIELEEIGGRAE"
BASE COUNT         2938 a         1656 c          877 g         3753 t
ORIGIN      
        1 tcttaaatta cactaaataa tatctttcac actgttgctt tttctttaat aatactaaat
       61 agtatctttc acactgtttc tctttcttta ataatactaa ataatatttt ccacattgtt
      121 gctttttcta aacaactata aataatatat taaaccctta tttctttttc taataagtta
      181 aataatacat tttacacata tctatttgtc ttgcacataa taaataatac attatatttc
      241 tatctaaatt tagattctaa attaaatagt ataaattata ttcttcaata aacaagtttt
      301 caaatccaag attcgctctc tatctttaaa ctttattgta aacataattc catctttttt
      361 aattatttct ccttcatgaa attttttatg gtatacctta tcccctacac caatactgtc
      421 aatttctttt ttcgttggag attttatatc attaataaat aatgatttat caactttctt
      481 accatactta tttaaagtag agcttataca taacttttct tcagctcttg taatagcaac
      541 atacataagt cttctttctt cttctaattg ttcttctttt ttctcttcct tacaaatatc
      601 atatgatttt tcatgaggta ttgttccttc atttacacct ataatataaa catttctaaa
      661 ttctaatcct tttgcactat gcatagttgt aaatatgaca ccctcagtct gcttattctt
      721 gttattttcc gttaactcag tctttactct atcaatatgc tctaaaaact ctgtaacagt
      781 attaaaatta gttgctgaac tctcaagttc atttaatatc tctacaagtc cattagtctt
      841 tatctttctg ttgctacaat aatctaaaac atatctatca taatcaagac tagttctaat
      901 ataagatatt gcatttttag gatttaaagt atttaaataa cttaaatcta tttccaaatc
      961 atttattgtt ttaacttgtt taggatgaag attacactta tttattaatg ctgttataaa
     1021 gtctttttca tccttaacca tatttatact gtctttggat atatatctaa aaggcttgtt
     1081 tataattctc aaccaatctt tatttgattt tggattaata cctattctta aataggctag
     1141 tatgtcttga cttgcccaat ggtcatatat tgtaattact gagtctttta ctacaaatgg
     1201 aatcctcata tccataaata catctactaa tgctcttgac tgtatattag ttctataaat
     1261 tactgcaaaa tctgaatact ctacataatc tttttgtatt tcgtcaatta tttccctggc
     1321 aatatataag gcttcttcct ctgaatcatg cggagaaata taggtaacac ttcctccatc
     1381 cccctgacta cacttaatga ttttttcata tctattttta tttttgtcga taagtctatt
     1441 tgcagtatgc actatctcac ttttagacct gtaatttata tctaatatta tttttttagt
     1501 attattaaag tattgttcaa attcaagcaa aaaatctggt ctagcacctc taaatccata
     1561 tatactttgg tcttcatctc caactgcaaa tatattgttt aatgggctac aaattaactt
     1621 taaaacttca aactgtactt tatttatatc ttgaaattca tctatcaata tatatttata
     1681 cacatttcta accatttcta gtgcagactt attgttcaaa agtaaataat aagttcttat
     1741 aagcatatca tcaaaatcta ttttattaac tttagatttt tgttcttcgt ataagttgta
     1801 tacttttaaa aactcatctt ttgttaatac ttctgaatta aattcatttt tatccataag
     1861 ttcatttttt acataggaaa tttcatttat aacttgtcct atattctcat catcatcagc
     1921 attctctata tttaaacttt ttaggattgc cttgattgtc attcgctttg acttttcatc
     1981 aaatatactg tctaagttgt atctttcaaa gtatcttaga attttaaaaa atacagagtg
     2041 aaaagtacca taggttacct tattaagtct tatgtcatca cttaaattca aagctctatt
     2101 tttcatttct attgaagatg ccttggtaaa acttattgcc aagattcttg ttggtgctat
     2161 gtttttgttt acaaccatat tggctattct atatgtaatt actctggtct tacctgaacc
     2221 aggccctgca agtatcatgc aaggcccatc tatatgctca actgcttcta attgattttc
     2281 atttaacttt cttatatcta tatttgttgt gattattagc tccaccacct tgatttataa
     2341 ttatattatt ttctttttaa ttataaacta aaagttcata aaaataaatt taatttttcc
     2401 tctattaaac cacatcattc ctattttcat gacatatctt gagttctttt ttaattttgt
     2461 cgcttatatc ttcaggtata aatgatggtt tactaatata gtagccttgc atataatcta
     2521 ctccaagatt aattagtgtt tccatttcac cttttgtttc tacaccttct gctatcactt
     2581 taatatttct ttcgttagaa tatgagataa gattttttaa tattttctgt ctgttttcat
     2641 ctttatcaat acctcttaca atagacatat caatctttac atagtctggc attatatata
     2701 atagtacagc atctccgttg taacctgtcc caaaatcatc taaagcaatt tctatattcc
     2761 aatggtctat atatgctttc tttttctcaa taaaatcttc attaatctta tcattctctg
     2821 ttatttctag tactactcta tttaaatatt caccatataa atcttcaatt tcctcaaaat
     2881 ctacttttga caaattatta ttaggaatag aatttaagaa cagtttgcaa tcgccaaatt
     2941 tttctttgta ttttttaaat gatttaagtg ctttaaacca tgtaatacgc tcaatttgat
     3001 ataatttaga ctgtgaacga gctaatctaa tgacatctat tggcgaacta aaagttttta
     3061 ttttaggtct cataagtgct tcatatgcaa atactttacc tttacaatct acaataggct
     3121 gaaatgcata ctcaactaat tgaccatcaa ttaacttgtt taattcttct ctattactca
     3181 ataagaatga atccttatta tatatattaa tatcaaattc actaacttca cccttgattg
     3241 tatttttaat ttgatacata gcaaaatctg cgtatctcat taattcatca tagttggttg
     3301 aatcatcagg gtaccaggaa attcctgctg atgcccttat tttaaattct gttccatcat
     3361 gaagttttaa taaggtatta ttcatctgtt tcttaacaga attaataata tctcttatac
     3421 tatctttact ttcatatcca tatataaata cataaaactc atcacctgaa agtctagata
     3481 ctataccatt ccatgatata aacttcttaa gtatgtctgc agcacaccta atatattcat
     3541 caccagcatc atgtccatat gtatcattaa tatattttag attatctaaa tcccacataa
     3601 taaatgctgc tatcttaagt tcatctttat tcttaaattt ttcttgtatc tgtgaatgaa
     3661 aagctctcct atttaaaaga ttcgttaaaa tatcaaaatc tctttcatat tctatcttcc
     3721 ttttctcaat aaattctttt gttacatcaa caacaacacc aagaaccttt agctcatctt
     3781 caaagatatt cattcttatc cacttaagtt ttttatcttt agattcaaac ttatatatat
     3841 atgtattttc tgtttcataa ctttcttgca aatatttatc tagtcccctt aattttttca
     3901 ggaacttatt tttttccata tatccatatt cttcaaattt gatttcagta gtaaacacgc
     3961 taaaaaattc ttttgtacaa aaaacattct ctgcgttttt gtataactca aaagctccaa
     4021 ttggcatatc taccatttca ataatctgtg ataattttga cgaagaatct gcaacatttg
     4081 cactgagcaa ctctatagct gaagataatt catctatttc agatatattt atcttatcaa
     4141 gatttactgg ttttgatgga ttactgtttc taactttgtt ggctaaaaga acaattggtt
     4201 ttgtaaataa tcttgatgca atgtaaatac ctattagacc tattaataaa gaaattgcta
     4261 tagatattat aactaatttc tctacccttt ttgaaaatga caaaagactt ttttcttcaa
     4321 taatacccaa aagagcccaa cgttcatttt caaatggagt attggagtta tataaatcta
     4381 agtattgtac actagcataa atgttgccat taccacattc attatcttta tttttaatct
     4441 tatatatatt tttatacgat tccttctgct ctaaattaga atgtaaacca tcccaaaatt
     4501 tttcttttaa tgagtatcca tttgaaatta cattttcaaa ggccatatca ttatttctat
     4561 ctacacctaa aatataatta ccctttttat tcccatttat ctctgagtat ggaagtaatt
     4621 ctcttaagta atttacactt aaatctattc caagtactcc atatacagtt ccatcttcat
     4681 aaataagggg aactgtatat gtcataagcc tatcacctgc atttgtcaat aaaaacttac
     4741 ttccccagta tcctaaatta gaacttgata catttggatt atcaattgca gctctaaatg
     4801 gtttataaaa aaaatcatct ccatcttgct cattttcact tttaaatgaa aacttaggtt
     4861 cccaataact gtccatagat attccaaaac ttcttgctat atctgatgaa cctctctcaa
     4921 ttaacaaatc agaattatca tttggattaa acttagggtc taaatccctt atatacaatc
     4981 ctgtcctact tatttcacct ttactatcta ttgacttatc gttaatattt ttgtcactta
     5041 ggattataaa agctcctgta acagaatttt ttctcaaaag atatattaaa tcatttgata
     5101 tgctttttat aatatctttg ttaatttctt cattgttgcc tacatcctca attaaggcat
     5161 ttttttcatt taatactttt tttacagagg aattaattgt agcttccgtt tcacttgtat
     5221 ttgaccatct ttgtaacatt tcattttgta tataattttt acgattaatt actctttcat
     5281 ttaagatgtc aaacgaatta tcatttaatt tcttaatagt tcctccccat aaaattgtgg
     5341 cacaaaataa acttgtttga attagcataa caataattag gggaaatatc atctttttca
     5401 ttattgaatt gttttttctt agattgtttt ccatacccat tccacctata cctttgtgct
     5461 cgtcaacaca ctaactgcca attcatctat ttttttatag cattttcaag ctcagcctta
     5521 aaactttcaa accaagtttt aaaattttta tcattattaa attgtgctac tgcatccttc
     5581 ttagaagttc cactttttac taattcattt attttatttg aatcttcttt agctttatca
     5641 agcattgaat attcaagtat ttgtctagct ttagttccac catcaaatgc tttattagta
     5701 tataaattac aactgttaat ctgttcaata gatgaggcta ttgaaccttc aactttatca
     5761 gataaactca aattatcttt cttcataact tcttttataa catccaaatc attcgttttt
     5821 ttctttactg gtaagtatcc agaagcaata gagaatttta tattaggttc tttatctgta
     5881 aaccatttta aaaattctac tgatgcatat tcttcttctt tagtagattt tgttacagcc
     5941 attcctgcac cttgttgtac agcatatttt ccttctcctt taaaacgtgg tgcttgaaaa
     6001 acagatgttt caatattata actctcatta tcatttagca ttactctatc tggaaagtat
     6061 gctgctcctg aactagaacc tacaagagct aatatatcac ctgtttttgc atcatcagaa
     6121 cgaaacttac cataagaagc aaaatatcca tttatatatg gtacatagaa attatcccat
     6181 agttttttca taactttttc atcaatattt agtgtaactt taccatcttt aacagaaaaa
     6241 atttctactc ctagttgttt acttcctata ataatataat ttgctaaagc atctcttcca
     6301 aaaaatgctt taccatcatt aggctctttc gttaaactat ctgtccattc ataatatttt
     6361 tttgatgtct ctactaatcc ttcaattgtt tttatatcat ttatatttga atttgtagct
     6421 tttgcaaatt tatcccaatc agttttattt aacatcaaaa tttcagttga ttttgcaatt
     6481 gggaaaagtt taaactcatc cttagaattt attctgcctt cttctacata ttcgtctatg
     6541 tattcattta attcttcttt acttatgtac ttatccatat ctactagtaa ccctaattta
     6601 tccatttcat atgcagtatc tgagtatgct gcaaatatat ttggtacatc ttcagaacca
     6661 acttttttat ttgcagaatc taaaactttc tctgataaat caactacatt accttgactg
     6721 aatgcttcaa caataattcc tttttcagca cctacagtgt cattaaattc cttaacaagc
     6781 ttatcaaaag ccattttctg ctgtccatta taataatgcc aaatttgtat tgatgtcgga
     6841 ttttctgggt ctaacttata attatcttcc ttctttaaac tacatcctgt aagtaataaa
     6901 acaatcattg atgtgataat taattttgca aacttacacc tattcataaa atctactcct
     6961 tcaaattata aaatttataa tagcattaaa actgtaactt cactatttat attaattata
     7021 gaacgtttat tgatatattt aaacaggatt tacaacatat ttaaaagcaa ttaagaaaca
     7081 tactattaca aatatagaaa ataaagcttt tacataattt ttatttctaa atgcgccaaa
     7141 tgacaccaat ccttgttgaa tagctactgt aattactaaa agtatcatta ttatattaag
     7201 ttgaaccagt ttaaataagt aaagcaatga aaacactact agaagtacac ataatacaat
     7261 actagattta ttaataatat catcaatctt atctaccttc ttagattgct tattaacttt
     7321 atttaatttt tctttattta aattctcaac ttttttatta tacctttctc ttgttttatc
     7381 tttatattta gtatttttat ttttatttcc catttatttt ccatcctcta taaatttttt
     7441 aattgagctt atacattatt taaatattat atatttaaga taccatatat tcctacaaaa
     7501 aggtaactta ctatgtatct atttttgatt ttcgcataaa aaagccatct cctttagaat
     7561 taattctgta ttgagacagc taatttaact atttatcctt tgaaacattt tctacattat
     7621 catatttact atcaactaaa actatatcaa ctcttctatt ttttgaccta ccttcttcag
     7681 atgaattttc tgctattggt ctaaactcac catatcctac agcagataat ttatctggtg
     7741 ctatacctgc attgtcaata agaagttgaa caacattggt tgctctcata actgataaat
     7801 cccaatttga cttaaactct gaatttttta tagacatatt gtctgtatgg ccttctactc
     7861 tcatgtaact attcatttca tttaacatct tacctatttg aataatctta tctctagaat
     7921 tatccttcac aatcgctttc cctgtatcaa atagtattgt atctttaagg cttattacta
     7981 atcctctatc ttgaactctt aatgatactg aattagccat accattttca tttaaatact
     8041 tctggatttc ttcaccaact tttttaaact tagcattttg taaagtatct aaatcattac
     8101 ttcctggttc aactactggt tctatcttgc tattaccacc ttcaataact ccagaagaac
     8161 caccaaaagc agaatttaga gattgagata attgtttata tttctccgca tcaacattac
     8221 tcatagaata cattattaca aagaaaatca taagtaatgt tatgaggtct gaataagtta
     8281 aaagccatcg ctcattgttt tcttcttttt catcttcatc atacaacata aacattccat
     8341 ccttttatat tattcagctc taccaccaat ttcttcaagt tcaattagtt cttttgaatt
     8401 taaaaatatt tttaattttt ctgtcattaa attagaatta tcaccttcaa gtatggataa
     8461 tattgcttct atcaccaaaa gtctttcact tatttcctgt tgatttatag ccttaagttt
     8521 tgatgctatt ggtaaccata ttaaattggc agaaccaaca ccatacaaag tagccaagaa
     8581 tgcaacagaa atttgaggtc ctaatgcatc tggattactt gaaagattac ctaaaatatg
     8641 tactaacccc ataactgtac ctattatccc cagtgtaggt gcatatcccc ctgctgaatc
     8701 aaaaattgct attccttctt tatgtcgttt tgatgttatc tgtatctgtg attccaatat
     8761 atttcttata gtaactgcat ccactccatc taccataagt tcaagccctt ttctaataaa
     8821 agggtctaat tcatcattct cacttatttc tttgtcaata ctaagaagcc cctctttcct
     8881 agcctttgtt gcaatttctt tgaaatagat tatattttct atgttattag gctttttatt
     8941 tttaaaagct aataacatta tctttataga ctttttaaac acagggaatg gagtcgaagc
     9001 tccaacagct cctatagttc caccaaacac aacaagtgct gatgaaaata caaataatgc
     9061 tccaacatgt cccccatcaa taacaaaagc aactaccaaa gatgctatcc ccactatgaa
     9121 aaaaattaaa gttgtcatct attccctcct ttctttagtt atacatatct aatcatttat
     9181 gacattataa aaagactatc tttaataaaa atagccttta ataa
//
LOCUS       DAEQCW010000126         9169 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.127, whole genome shotgun sequence.
ACCESSION   DAEQCW010000126 DAEQCW010000000
VERSION     DAEQCW010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9169)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9169)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9169
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.127"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(75..266)
                     /locus_tag="KRO40_003125"
     CDS             complement(75..266)
                     /locus_tag="KRO40_003125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1450 domain-containing protein"
                     /protein_id="HBH2093925.1"
                     /translation="MIRVCPNCSNVDVNKLKTLVGEENVKTGCIGQCRAFKKEAVGII
                     DNELEIKETEAEFFEACKE"
     gene            complement(414..656)
                     /locus_tag="KRO40_003126"
     CDS             complement(414..656)
                     /locus_tag="KRO40_003126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093926.1"
                     /translation="MLEVTKIIIKYFASESDTFVKEEVCNFEELLKWSHKFIEGKKIE
                     DVLYIKSKENYKVNVIKSLEIKELEIVRKQQIPPYM"
     gene            868..2691
                     /gene="typA"
                     /locus_tag="KRO40_003127"
     CDS             868..2691
                     /gene="typA"
                     /locus_tag="KRO40_003127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HBH2093927.1"
                     /translation="MSQKHKIINIAVIAHVDAGKSTLVDAFLSQSGVFRKNEVVKDCV
                     MDSNDLEKERGITIYSKNCAINYEDYKINIVDTPGHSDFSSEVERVMKTVDTVILLVD
                     ASEGPMPQTRFVLQKSLEFGLKPILFINKIDKKDQRAEEVVNEVFDLFVDLNATDEQC
                     EFPIIYGIAKQGIAKLEMDDDSEDLSPLFKTIVNHVEAYPNYDNEPLQFQISALAYDD
                     YVGRLGIGRIYKGTLKNNTQVAICREDSVVSKGKVSKLSVYEGLKQVEVDEATSGEIV
                     VIAGIPDISIGETICDLDSPLPMEMIKIEEPTLSMNFLVNDSPFVGKSGKFVTTRHLK
                     DRLEKELEVNVGLKVEPLDTTDGYKVSGRGELHLSILLENMRREGYEVGVSKPEVLMH
                     KEDGKLMEPIERVVVNCPEVYSGTIINELNMRKGMMESMSIEGDYVKIEFLAPTRGLL
                     GYRSEFINATRGEGTLVRSFEKFEEFKGEIPSRGNGVLIAQGPGVTMGYSLNALSDRA
                     VMFVDPGVEVYEGMIIGMNSRKDDMVVNPCKNKKMSNVRASGSDDAIKLSPPRIFTLE
                     EALEFIEDDELVEITPDSIRLRKRFLNEHDRLRYNKSRQGK"
     gene            complement(2781..3689)
                     /gene="trxB"
                     /locus_tag="KRO40_003128"
     CDS             complement(2781..3689)
                     /gene="trxB"
                     /locus_tag="KRO40_003128"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBH2093928.1"
                     /translation="MVDIIVIGAGPAGLTSAIYAMRAGLSVTVFEKNIYGGQVASTSE
                     VENYPAVQKISGVEFSNNIYNQAVAQGVDIQFDEVEEINLEGKVKVVKTSSGEHKAKA
                     VILANGVERRKLGCAGEQEFTGRGVSYCATCDGAFFKDKEVAIVGGGNTALEDALFLA
                     NNCTKVYLIHRRDSFRGEEVLEKSVKARENIEILYSHGVEKIEGEKTVSKIEVKNLKT
                     EEKRTIDVSGIFIAIGLKPNNKMFENVLDLDEGGYIISDESCTTSVEGVYVAGDSRTK
                     FLRQIITAASDGAIAAVQAANYINVE"
     misc_binding    4491..4722
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            4830..6311
                     /locus_tag="KRO40_003129"
     CDS             4830..6311
                     /locus_tag="KRO40_003129"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HBH2093929.1"
                     /translation="MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELIN
                     LVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDEKFDCSSIAPLNKVNDTYFLELY
                     HGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
                     IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNN
                     YILSSANSINIGRLLPQVAYYFYSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYA
                     KQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMDILISSNLERLLFEI
                     SNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYL
                     IDTHTAVAYNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIID
                     RLSSISKIDIPKPIKNLKNAEILHKDIYEKDELKLAIKKFLKV"
     gene            6321..7214
                     /locus_tag="KRO40_003130"
     CDS             6321..7214
                     /locus_tag="KRO40_003130"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HBH2093930.1"
                     /translation="MLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGC
                     EDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKIKIQSEVPICRGLGSSASCIVAGVIA
                     ANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPEELK
                     FCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKL
                     HQDYRGTLIENYNDIVEKSEQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKL
                     KSDWEIKELCCDSNGAVLNII"
     gene            7338..8399
                     /locus_tag="KRO40_003131"
     CDS             7338..8399
                     /locus_tag="KRO40_003131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitronate monooxygenase"
                     /protein_id="HBH2093931.1"
                     /translation="MIIKELIIRDLVAKVPIIQGGMGVGISRSSLAGAVAKLGGVGVI
                     SGVQIGYDEEDFETNTINANLRAIKKHISKAKEISNGGIIGINFMVAMKEYETYVKEA
                     VKAGVDLIISGAGLPNKLPSLVKGSNVKIAPIVSTAKAANVILKMWDRKEKTTADLIV
                     VEGPKAGGHLGYSNEELDNIDSIDYDKEFVEILKVANTYGEKFGRNIPVVAAGGITSS
                     SDVKKYIDMGASGVQVGTRFVATYECDAHENFKMAYINASEEDVHIVKSPVGLPGRAI
                     RNKFIEEVKINRPEIKKCYNCLIPCNPKETPYCISQALINAVKGDVENSLLFCGNDAY
                     KIDKLSTVEDVINELISEL"
     gene            complement(8554..9066)
                     /locus_tag="KRO40_003132"
     CDS             complement(8554..9066)
                     /locus_tag="KRO40_003132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
                     /protein_id="HBH2093932.1"
                     /translation="MSDFKEILAEEIKNNPFGLIGKDWTLITAENEGKVNTMTASWGG
                     LGVMWGKDVAFVVIRPQRYTKEFIDNTDKFSLTFFDEDFRKELSYCGKVSGREEDKIS
                     QIGFNIEHLNDTPYFKESKMAIICKKMYSQKLEPQCFIAEGIDGRWYPQKDYHTLYIA
                     EITNVLVKED"
BASE COUNT         3295 a         1284 c         1312 g         3278 t
ORIGIN      
        1 ataaaaatag agcatctaaa ttgtttaatg cttatacaat ttagatgctc tatttattat
       61 attttattta aaatttattc tttacatgct tcaaaaaact ctgcttctgt ttcctttatt
      121 tcaagctcat tgtctattat tccaacagct tcttttttaa atgctctaca ctgacctata
      181 caaccagtct ttacattttc ttctccaacc aaagttttta gcttatttac atccacattt
      241 gaacagtttg gacatactct tatcatattt aagttcctcc taattaatgt ctaattaata
      301 cttttatacc caaatataaa ctttataaaa gtttttttaa tataaattat taccatatat
      361 accatttata tcctattgcg agtattacat attaatttta tatattatta atactacatg
      421 tacggtggta tctgttgttt tctcactatt tccaattcct taatttctaa agacttaatc
      481 acatttactt tatagttttc tttagacttt atatacaaaa catcttctat ctttttacct
      541 tcaataaatt tatgagacca cttaagaagt tcttcaaaat tacaaacttc ttcttttaca
      601 aaagtatcac tttcacttgc aaaatattta attattattt tggttacttc caacatatat
      661 catcctttac tcttttatta atctttttat ctattaaggt tattatttgt ctaaaaaatt
      721 tttttaaaca aaataatttt cagatgcaaa actaacagtt ttattcaatt taaactatat
      781 taatacaatt taatatattc ctccttgtac ctaataatat attgtgctat aattaataag
      841 ttattttaat cgaagggagc aacaaaaatg tcacaaaaac ataaaattat aaatatcgca
      901 gttatagccc acgttgacgc tggaaaatca acattggttg atgctttcct ttctcaaagc
      961 ggtgttttta gaaagaacga agtagttaaa gactgcgtta tggacagtaa cgaccttgaa
     1021 aaagaaagag gcataactat atattcaaaa aactgtgcaa taaactatga agattacaaa
     1081 ataaacatag ttgatactcc aggacacagt gacttttctt ctgaagttga acgtgttatg
     1141 aaaactgttg acacagttat tctattagtt gatgctagtg aaggcccaat gcctcaaact
     1201 agattcgttt tacaaaaatc tttagagttc ggtttaaaac caatattatt tataaacaag
     1261 attgataaaa aagaccagag agcggaagaa gtagttaatg aagttttcga tttatttgta
     1321 gacttaaatg caacagatga gcaatgcgaa tttcctataa tatatggtat tgctaaacaa
     1381 ggtattgcta aacttgaaat ggatgatgat agtgaagacc tttctcctct atttaaaact
     1441 attgtaaatc acgttgaagc ttatcctaat tacgataatg aacctctaca gttccaaata
     1501 tcagctcttg catatgatga ttatgtaggt agacttggta taggtagaat ttacaaaggt
     1561 actcttaaaa acaatacaca agttgctata tgtagagaag attctgttgt atctaaagga
     1621 aaagtatcaa aactttctgt gtatgaaggt ttaaaacaag ttgaagttga tgaagctact
     1681 agtggagaaa tagttgttat agctggtatt cctgatatat ctataggtga aactatatgc
     1741 gatttagata gtccactacc tatggaaatg ataaaaatag aagagcctac tctttctatg
     1801 aacttcttag taaacgactc tccattcgtt ggaaaaagtg gaaaattcgt tacaactaga
     1861 catttgaaag atagacttga aaaggaactt gaagtaaatg ttggtcttaa agttgaacct
     1921 cttgatacta ctgatggata caaagtttct ggacgtggag agcttcactt atctatacta
     1981 cttgaaaata tgagacgtga aggttatgaa gttggtgttt ctaaacctga agttttaatg
     2041 cataaagaag atggaaaact aatggaacca atagaaagag ttgttgtaaa ctgtcctgaa
     2101 gtttactctg gtactattat aaatgaatta aacatgagaa aaggtatgat ggagtctatg
     2161 tcaatagaag gagactatgt aaaaatagag ttcttagcac ctactcgtgg tcttttagga
     2221 tatcgaagtg aatttataaa cgctactcgt ggagaaggta ctttagttcg ttcatttgaa
     2281 aaatttgaag aatttaaagg agaaatacct tcaagaggaa atggtgtttt aatagcacaa
     2341 ggacctggtg ttactatggg gtattctctt aatgccttaa gtgatagagc tgtaatgttt
     2401 gtagaccctg gtgtagaagt ttacgaaggt atgataattg gtatgaattc cagaaaagat
     2461 gatatggtag tcaatccttg taaaaacaag aaaatgagta acgtacgtgc ttctggttca
     2521 gatgatgcta taaaattatc tcctcctaga atatttactc ttgaagaagc actagagttt
     2581 atagaagatg atgaattagt tgaaattaca cctgattcta taagacttag aaaaagattc
     2641 ttaaatgaac atgatagatt aagatataac aaatctagac aaggtaaata aaacgtacat
     2701 ttacctctaa ttaacaaaat agccatatag tactgaaaaa ttatttcagt ttatatggct
     2761 atttttattt gaaatttata ttattcaaca tttatataat tagctgcttg aacggctgca
     2821 atagctccat ctgatgctgc tgttattatt tgacgtaaaa acttagttct actatctcct
     2881 gctacatata caccttctac tgatgttgta caagactcat ctgaaattat atatccacct
     2941 tcatccaaat caagaacatt ttcaaacatt ttattattag gtttaagacc tatagcaata
     3001 aaaataccac taacatctat agttcttttt tcttcagtct ttaagttttt tacttctatt
     3061 ttcgatacag tcttttctcc ttctattttt tctacaccat gactgtaaag tatctcaata
     3121 ttctctcttg ctttcacaga tttctccaac acttcttcac ctctaaaact atctcttctg
     3181 tgaattaaat acacttttgt acaattatta gctaaaaata aagcatcttc tagtgcagta
     3241 tttcctccac ctactatagc aacttcttta tctttaaaaa aggctccatc acatgttgca
     3301 cagtaagata ctcctctacc tgtaaattct tgttcccctg cacaacctaa tttacgtctt
     3361 tcaactccat ttgcaagaat aacagccttt gctttatgtt cacctgaaga agtttttaca
     3421 acctttactt ttccctctaa atttatctct tcaacctcat caaactgaat atcaacacct
     3481 tgagcaactg cttgattgta tatattatta gaaaattcta ccccagaaat cttttgaact
     3541 gctggataat tttctacctc agaggtactt gcaacttgac ctccataaat atttttttca
     3601 aatactgtaa cgcttaaccc tgctctcata gcataaattg ctgaagttaa acctgctggt
     3661 ccagcaccaa ttacaatgat atctaccata acgtttacct ctctttatat tattatttct
     3721 tatatattat tctcatcatt cttatacttt actattatta tccatatata ctataaacaa
     3781 aacattattt tttattaatt aactttattt tacatatata taaaaaaact gcaaataaaa
     3841 attaactttt atttacagtt ctcacttatt tatataattc aaaaccttat tggttatcat
     3901 ttacagtgtc ttctaatata ttgctttctg atatatatga tagaattgaa agtccataca
     3961 taaccaaaac taatgctgct gttataagta ctattcccat atttaatacc tccttttgtt
     4021 tacagtatac tattattatg tgaaatattt atgaatttaa tttgaatata tatgtaattt
     4081 cacactaaca atttcttcaa attaaacatt attaactata tacttttgtt gaaccaatta
     4141 tgattaatag tttaaatatt agcactattt acttatattt atatgatata ccatataatt
     4201 acatttttca aattaaagtt ttgtaaactt tttttgtaat atagtgtagt ataaaattgt
     4261 aatattacag atatttaata gttatctttt aattactttc attaaaaaca gcttcatcac
     4321 tatgaaaatc taggttttta aacttttaaa aaagttaaaa aaatattttt ctaatactca
     4381 atttgattac aattttttta caatttaaaa aatatttttt ccaaattttt atattaatac
     4441 ttgactttgt ctgttttata aactagaata attaataata ttaagaatat tgaaaggcat
     4501 tgattaggaa gagtaaatct gaatcgatta ccagagaagg aaactactag ctgaaatgtt
     4561 tccctaatta gaaggattga aaactaccta ggagcttcta tccgaagtta tcttaatgat
     4621 tttagtagga atagacgttt ttattacttg cgttaaagta tcaagtggat tttttaaaat
     4681 caatttgggt ggaaccgcgg gaaacagatt ctcgtccctt ttttagggat gagggtcttt
     4741 ttttattacc taaattcagt ttttaaaata ttctgtatct aatttaatta gctaattaaa
     4801 aatttaaaat atatggagga ttataaaaaa tgtattattc aagtacgaga ggcaccgaag
     4861 aaaaagtaac tgcatcacaa gcaataataa aaggaatatc aaatgatggt ggtctttatg
     4921 ttccaagtga atttcccaat gtaaaaaatg aacttataaa tttagtaaat ttaacgtatt
     4981 ctcagatagc attttttgta cttagtaaat ttttatgtga ttttactgaa gatgaaatta
     5041 aaaattgtat agaaaatgca tatgatgaaa agtttgattg tagtagtata gctccattaa
     5101 ataaagtaaa tgatacttat ttcttagaac tatatcacgg tccaacttta gcatttaaag
     5161 atatggcact tactataatg cctcatcttc ttaaaacatc tataaagaaa gataatttag
     5221 agaaagatgt tgtgattctt actgctacat ctggagatac aggtaaagct gcacttgagg
     5281 gatttaaaga tatagataaa ataaagataa ttgtattctt cccagaagat ggtgtaagcc
     5341 cagtacaaaa acttcaaatg aaaactcaaa ctggaaaaaa tacatatgta gttggtataa
     5401 aaggaaattt tgatgatgca caatcaggtg taaagaagat tttttctgat aaagaattta
     5461 atcaaaaact attggataat aattatatat tatcttctgc aaattcaatt aatataggaa
     5521 gacttcttcc acaagttgca tactattttt attcatatat gaaattagtt agcaatagtg
     5581 atataaattt aaatgataaa ataaattttg ttgtcccaac tggtaatttt ggtaatattc
     5641 tagctggata ttatgccaaa caaatgggtc ttccaataaa caaattaata tgtgcatcaa
     5701 atgataataa tgttctttat gatttcttta aaactggtgt atatgataaa aatagaacat
     5761 tgaaattaac tacttctcct tctatggata tattaatttc aagtaattta gaacgattac
     5821 tgtttgaaat atcaaataga aatactgata ttgtaaataa gcttttatca gaccttagtg
     5881 ataaaggagt ctacaaaata agtgatgata tggaaaaaaa tttagcctca ttctatggag
     5941 aatattcaaa tgaagaagaa gttaaaagca cgataaacaa tgtgtttaaa aattataatt
     6001 atttgataga tactcatact gctgttgcat acaattgtta tgaaaaatat aaaaaagaaa
     6061 cttctgataa cacaaaaact gttattgtaa gtactgcaag tccattcaag ttttctgaag
     6121 atgttctaaa gtctatagat tgtgatttta aagaccttga tgactttgct ataattgata
     6181 gattatcaag tatttctaaa atagatattc caaaacctat taaaaatctt aaaaatgcag
     6241 aaatactaca taaagatatt tatgaaaaag atgaattaaa actagctata aaaaaattct
     6301 taaaggtata ggtgattatt atgttagaga ttatagttcc tgcaacaagt gctaatatag
     6361 gtccaggatt tgattgtctt ggaattgcgt taaatatata caataaattt tatgttgaag
     6421 aaattgaaag tggtcttgaa atagaaggtt gtgaagatgc ttacaaaaac gaaaacaact
     6481 tagtttatac atctatgaag tacttttttg atagagttaa accagaaaaa atacctgctg
     6541 gtatcaaaat aaaaatccaa agtgaagtac ctatatgtag aggtcttggc agtagtgcct
     6601 cttgtatagt agctggagtt atagctgcaa atgctctatc aggtgctaat ttagataaaa
     6661 atcaattact aaatatagct tcagaaatag aaggtcaccc agataatgtt gctcctgcta
     6721 ttttaggaaa tatgattgta tctgttactg ataatgagaa tatacattat gatattataa
     6781 aaattcctga agaacttaaa ttttgtgcaa tgatacctaa ttttaagtta tcaacagaaa
     6841 aagctagagg tgttttacca aaggaaatac catattctga tggggtattc aatgttagta
     6901 gagttgcttt actaatatct gccttactaa acaaaaactt tgacctactt aaagtagctt
     6961 gtcaagacaa attgcatcaa gattatagag gaactctaat tgagaactac aatgatattg
     7021 ttgaaaaatc tgaacaatta aatagtattg gagtattttt aagtggagct ggacctacta
     7081 taatgtcttt aataaaagaa aatgatgata gttttgtgga taatatgaaa aattacctac
     7141 aaaaactaaa atctgattgg gaaataaaag agttatgttg cgattctaat ggagctgttt
     7201 taaatataat ataattatcg tcttctatac aaaatataac tactctttta ttataatttg
     7261 tagtataata attaggacta ggtaataata ttaagtatta taatctagtt ctttaaacat
     7321 gtttacattg aggagggatt atcataaaag agttaataat tagagattta gttgcaaaag
     7381 ttcctataat tcaaggtgga atgggcgttg gtatatctag gtcatcacta gctggtgcag
     7441 ttgctaagct tggtggtgtt ggtgtaattt ctggagttca aattggatat gatgaggaag
     7501 attttgaaac taatactata aatgcaaatt taagagctat aaaaaaacat atttctaagg
     7561 ccaaagaaat ctcaaatggt ggtattattg gtattaattt tatggtagct atgaaagaat
     7621 atgaaacata cgtaaaggaa gctgttaaag ctggtgtaga ccttataata tctggagctg
     7681 gattacctaa taagctacca tcattagtaa agggaagtaa tgtaaaaata gcacccatag
     7741 tttcaactgc aaaagctgct aatgtaattt taaaaatgtg ggatagaaaa gagaaaacta
     7801 ctgctgactt aatagttgtt gaaggtccaa aagctggtgg tcaccttgga tactctaacg
     7861 aggaacttga taacatagat tctatagact atgataagga atttgttgaa attttaaagg
     7921 ttgcaaatac ttatggagaa aaatttggta gaaacatacc agtagttgct gctggtggta
     7981 taacttctag tagtgatgtt aaaaaatata tagatatggg tgcaagtggt gtacaagttg
     8041 gtacaagatt tgttgctact tacgaatgtg atgcccatga gaactttaaa atggcataca
     8101 taaatgctag tgaagaagat gttcatatag ttaaaagtcc tgtaggtctt cctggacgcg
     8161 ccataagaaa caaatttata gaagaagtta aaataaatcg tccagaaata aagaagtgct
     8221 ataattgttt gattccttgt aatccaaaag aaactcctta ctgtatttct caagctctaa
     8281 tcaatgcagt taaaggagat gttgaaaatt cacttttatt ttgtggaaat gatgcctata
     8341 aaattgataa attaagtact gttgaagatg ttatcaatga attgatttct gaattataat
     8401 ttaaagaaaa ctaaattaag attttatcaa gctaaggagt ttaaatacgt tatttattaa
     8461 tctttataaa catatttatg tccttagctt ttttgtgtca atttcctttt attgaaattt
     8521 taatttaatt agagatagta ttaaccctta taactaatct tcttttacaa gtacattggt
     8581 tatttcagct atatataaag tatgataatc tttttgtgga taccatcttc catctatacc
     8641 ttcagcaata aaacattgag gttcaagttt ctgactatac atttttttgc atataatagc
     8701 cattttagat tctttaaaat aaggtgtatc atttaagtgt tctatattaa atccaatctg
     8761 tgatatctta tcctcttctc taccagatac ctttccacaa tatgaaagct ctttacgaaa
     8821 atcttcatca aaaaatgtaa gagaaaattt atctgtatta tctataaatt ccttagtata
     8881 acgctgtggt cttattacta caaaagcaac atcttttccc cacataactc caagccctcc
     8941 ccagctagca gtcattgtat tcactttacc ttcattttct gctgttataa gtgtccaatc
     9001 tttacctatc aatccaaatg gattattttt aatctcttct gccaaaattt ctttaaaatc
     9061 actcatatct ctaataacct ctcattctct tatatttata ttccttttat tttcgtgata
     9121 aattataaat gaagtctagt tttgaaaata aaatactttt ttaaatata
//
LOCUS       DAEQCW010000127         9128 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.128, whole genome shotgun sequence.
ACCESSION   DAEQCW010000127 DAEQCW010000000
VERSION     DAEQCW010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9128)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9128)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9128
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.128"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            36..1040
                     /locus_tag="KRO40_003133"
     CDS             36..1040
                     /locus_tag="KRO40_003133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2093933.1"
                     /translation="MRFKRILILMLTVAMIAGMLVGCANNPSNNPSSSKDNKSDISDK
                     SNSKKSVSMILDIEGTNNEAMNNSALLALNNAQKKLNIDTNKVESDDSSTFSNSIDIL
                     CNDNYDLIIAVGARFAKPLEMVAKKYPKQQFAIIDYEYDKQPSNITSISYEDNKSGYL
                     AGLIAGKMTESDKVGFIGGTKSSSRDKFESGFREGVKFSNSSIRDISVEYADVFKDSK
                     SVESIAKKMMDNGVDIIFSTTEDDSKAVIDAVRAKNKKVIATNKDQHELAPENVISSV
                     VKDFENPTYNLIQSFVKGNYKGGKVIENTVKSGSTGLAQNSSQNIPPDVLEYVNKNNK
                     "
     gene            1166..2278
                     /locus_tag="KRO40_003134"
     CDS             1166..2278
                     /locus_tag="KRO40_003134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2093934.1"
                     /translation="MKIKRILMACFVVVFTIFILAICNFDFGFDKVNKNNSNIDSAKS
                     KQNESKSLPTSAEKDKSNSKSKNKEDDTEDDSYVRKTIGVLLDTENLNNESYNNNVLS
                     ALKRADEDFDVRIKLEKPKTSKSFKESIEKLHKYEPDLIIAVGARFAEPIKEAATKYP
                     KQQFAIVDYTYKVQPANVISVSFQDNVTGYLAGLIAGKMTDTGKVGFIGGVEGSSRDK
                     YESGFRKGLKTSNKDAELLVKYSNIFENPESARTIAKEMRDSDRDVVFSATEDDSKRA
                     IQVARENGGKVIAINKDQYDMAPDNVISSIIKDVEQPVYELIKNVAKDGFKGSKVMEF
                     KIKDGELGLTSKSSRNIPPDVLEYIKKEYNKVKDTY"
     gene            2634..3395
                     /locus_tag="KRO40_003135"
     CDS             2634..3395
                     /locus_tag="KRO40_003135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093935.1"
                     /translation="MEFTREPFILDDDLCLALVDKRISYLMENELKLRNIEIIKTIEC
                     KELYESIKYHPDICICNLGKGDIIVAPNVYNQYKELLSRYKFNIIKGEANLLNRYPYD
                     IPYNIAIVGDYAIHNFKYTDKAILDYIENNKLKKINIEQGYSKCSICIVDRTSIITSD
                     KGIWKSMKNTEIECLLIEKGHINLFEMNYGFIGGCTGLISKDKLAFCGDVKKHPDYER
                     IKSFVESKNKEIVTLSCENLLDIGSIVPLMTRKER"
     gene            3398..4216
                     /locus_tag="KRO40_003136"
     CDS             3398..4216
                     /locus_tag="KRO40_003136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sporulation protein YtxC"
                     /protein_id="HBH2093936.1"
                     /translation="MVEKDNISSMKFLRNNNVNDRLIYTNDIVEVVIDSAKQEVLNKK
                     ILNGTKTEQRALNIDEISTEITSMIISIMKEKLLKEYILKCYGRTYPEDKNNIYIYSL
                     NIFAKKEIFMRETVFTRVRNYIEENDFINVEGFIRFRMREFMKYISAIGDIAVEEYLI
                     KKDQDEFIRVLKYFIDTQEEKIDLLKVHIMEDNTFVLYDKNGNKIDSIDDEEIINMVI
                     RENLNYEDFLISTLLTLCPKKIEILDLLNNNCSKEIIDTVEAIFENKVSIIMEN"
     gene            4396..4998
                     /locus_tag="KRO40_003137"
     CDS             4396..4998
                     /locus_tag="KRO40_003137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF445 family protein"
                     /protein_id="HBH2093937.1"
                     /translation="MDNLIRILILAVIGGFIGYVTNVVAIRLIFRPIEPIKIPILNIE
                     IVGLIPKRRAEIAANVGEIIQEEFLSMDEILANIITDEDKEEVVRYIKARVKIIIHEK
                     VSFIPSGIKNMIQDYLGEIIESEVKQSIDELSKNIINKANERIDIQKMVEDKINELDL
                     YELEEIIIRIAKKELKHIEFLGLVLGFLIGIAQGLITMFI"
     misc_binding    5559..5796
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            5860..7779
                     /gene="thrS"
                     /locus_tag="KRO40_003138"
     CDS             5860..7779
                     /gene="thrS"
                     /locus_tag="KRO40_003138"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HBH2093938.1"
                     /translation="MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEV
                     VGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILAQAIKRLYPEAKLAIGPSIENGF
                     YYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
                     SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIY
                     GTSFEKNKDLEEYLHLLEEAKKRDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNEL
                     LKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVKIDDEDYAIKPMNCP
                     GGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQI
                     KDEIKGVANLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPY
                     TINEGDGAFYGPKIDFHLKDCLGRTWQCGTIQLDMQLPRQFDNTYIGQDGEKHRPVMI
                     HRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKELFDKGIR
                     VELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIA
                     SISKEIESRESIIQD"
     gene            8547..>9128
                     /locus_tag="KRO40_003139"
     CDS             8547..>9128
                     /locus_tag="KRO40_003139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HBH2093939.1"
                     /translation="MIEKVEEKSKIIKTSKEYKRTIIEEKDKEWTKKLNDILSRSSFS
                     NDELDKIKALIPKEILTNENVGEVVTEDGYAKPEYDEVFKSLFTLNNEYDLLVNFIND
                     ILKDAPYANRNIKPFTQIKRIIRVETDPTINYIGEKRPRLDILAEDEENNHINIEMQR
                     AFENDYLERAEYYLSRVHGRKLEEGKEYKEIGKT"
BASE COUNT         3693 a          896 c         1652 g         2887 t
ORIGIN      
        1 taaaaatatc gtaaatgtat gaggagtgaa atttaatgcg tttcaaaaga atattgatat
       61 tgatgttaac tgtagcaatg atagctggaa tgttggttgg gtgtgctaat aacccaagca
      121 ataatcctag ctctagcaaa gataataaaa gtgatataag cgataaaagt aattcaaaaa
      181 aatctgtatc aatgatacta gatattgaag gaacaaataa tgaagctatg aataattcag
      241 ctttattagc attaaacaat gctcaaaaaa aacttaatat agatacaaac aaagtggaat
      301 cagatgattc ctcaactttt tctaatagta tagatatttt atgtaatgac aattacgatt
      361 taattatagc tgtaggagct agatttgcaa aaccattgga gatggtagcc aagaaatatc
      421 caaagcaaca atttgcaatt atagactatg agtatgacaa gcaaccttct aatataactt
      481 caatttctta tgaagataat aaatctggat acctagctgg attaattgct ggaaaaatga
      541 ctgaaagcga taaggttggt tttataggag gaacaaagag ttctagtagg gataaatttg
      601 aatcaggttt tagagagggt gttaaatttt ctaatagtag tataagggat atttcagttg
      661 agtatgcaga tgtttttaaa gatagcaaat cagtagaatc tatagctaaa aaaatgatgg
      721 ataatggagt ggatattatt ttttctacta ctgaagatga ttcaaaagct gtaatagatg
      781 cagtaagggc aaaaaataaa aaagttatag caacgaataa agatcaacat gagttagctc
      841 cagaaaatgt tataagttct gttgtaaaag attttgagaa tcctacttat aatctgatac
      901 aaagctttgt aaaaggaaat tataaaggcg gaaaagttat agaaaacaca gttaagtctg
      961 gaagtactgg gcttgcccaa aatagttctc aaaatattcc tccagatgtg ttagaatatg
     1021 ttaataagaa caataaataa tctactataa tatccaagaa tacttatgac tttagttatg
     1081 aggtgaaatg gatgttataa tagacatata tagaaagaca tatgcagagg taggttagac
     1141 ctatctaaat cagggagtga attttgtgaa aataaaaagg atattgatgg cttgctttgt
     1201 agtagttttt acaattttta tattagctat atgtaatttt gattttggat ttgataaagt
     1261 aaataagaat aattctaata tagatagtgc taaatcgaaa cagaatgagt ctaaaagttt
     1321 gccaacttca gcagaaaagg ataaatcaaa tagcaaaagt aagaataaag aagatgacac
     1381 agaagatgat tcatatgtaa gaaaaactat tggagtattg ttagataccg aaaacttaaa
     1441 taacgaatca tataataaca atgtactatc agccttaaaa agggctgacg aagattttga
     1501 tgttaggata aaacttgaaa aaccaaagac ttctaaaagt tttaaagaga gtatagaaaa
     1561 actgcataag tatgaaccag atttgataat agcagttgga gccagatttg cagagccaat
     1621 taaagaagct gctactaaat atcccaaaca gcaatttgca atagttgact atacttataa
     1681 agttcagcca gctaatgtaa tttctgtatc atttcaagat aatgttactg gatatttagc
     1741 aggacttatt gcaggtaaaa tgactgatac tgggaaagtc ggttttatag gaggagttga
     1801 gggttctagt agagataagt atgaatctgg atttagaaag gggcttaaaa cttcaaataa
     1861 agatgctgag ttactagtta agtattcaaa tatatttgaa aaccctgaat cagctagaac
     1921 tattgcaaag gaaatgagag attctgatag agatgttgta ttttcagcta cagaggatga
     1981 tagcaaaaga gctattcagg tagcaagaga aaatggtggt aaagttatag ctattaataa
     2041 agaccaatac gatatggctc cagataatgt aataagttca attataaaag atgtagaaca
     2101 acctgtatat gaactgataa agaacgttgc aaaagatggt tttaagggaa gtaaagtaat
     2161 ggaatttaaa ataaaagatg gagaacttgg cttgacttca aagagcagta gaaatatacc
     2221 accagatgtt ttggaataca taaaaaaaga gtataacaaa gtgaaagata catattaatt
     2281 attgatgtag aagattataa aaatatactg cttaagttta gattggtgat aaaaggatat
     2341 atttattaaa tttagtctaa ctgtacaaaa tatattgatt gagtttaggt tagcaataaa
     2401 aagatatatt tattaaattt gtgctaactg tacggaatat actgcttaag tttagattag
     2461 tgataaaaag atatatttat taaatttgaa ccaactgtac aaagctatac taattaagct
     2521 tagattaact atataaaatt ataacaataa gtgtgtgggc agaaaaattc tgctacacac
     2581 tttatttata ttcacataaa aaatttatca aaaaaaagaa aaaggagtaa aaaatggaat
     2641 ttacaagaga accatttata ctagatgacg atttgtgtct agctttggtg gacaaaagaa
     2701 ttagttatct aatggaaaat gaattaaaat taagaaatat agagataata aaaacaatag
     2761 aatgtaaaga attatatgaa agcataaaat atcacccgga tatatgtatt tgtaatttag
     2821 gaaaaggaga tataattgtt gcgccgaatg tatataatca atacaaagag ttattaagta
     2881 gatataaatt taatataatt aagggagaag ctaatttatt aaatagatac ccttatgata
     2941 taccttacaa tattgcgata gttggtgact atgctataca caattttaag tatactgaca
     3001 aagcaatatt agattatatt gaaaataata aacttaaaaa gataaatata gagcagggct
     3061 attctaaatg ctcaatctgt atagtagata gaacgtctat aataacatca gataaaggta
     3121 tttggaaaag tatgaagaat acagaaatag agtgtttatt gatagaaaaa ggtcacataa
     3181 atttatttga gatgaattat ggatttatag gtggatgtac agggttgatt tctaaggata
     3241 aactagcttt ttgtggagat gttaaaaaac atcctgacta tgaacgtata aaaagttttg
     3301 tagaaagtaa aaacaaggag atagttacac ttagctgtga aaatttacta gatataggtt
     3361 ctatagttcc tctcatgaca agaaaggagc gataactttg gttgagaagg ataatatttc
     3421 ttccatgaaa tttttgagga ataataatgt aaacgataga ttaatatata cgaatgacat
     3481 tgtagaagta gtgatagatt ctgcaaagca agaagtgtta aataaaaaaa tacttaatgg
     3541 tactaaaact gaacaaagag ctttaaatat tgatgagata tcaacggaaa taactagtat
     3601 gataataagt ataatgaaag agaaactttt gaaagaatac attctaaaat gctatgggcg
     3661 tacatatcct gaagataaaa ataatatata catatattca ctgaacatat ttgctaaaaa
     3721 agagattttt atgagagaaa cagtatttac tagggtgaga aattatatag aagaaaatga
     3781 ttttataaat gtagaaggtt ttattagatt tagaatgaga gaatttatga aatatatttc
     3841 tgctataggt gatattgcag ttgaggagta tttaataaag aaagaccaag atgaatttat
     3901 aagagtttta aaatacttta tagatactca agaagaaaag attgatttgc ttaaagttca
     3961 tataatggaa gataatacat ttgttttata cgataaaaat ggaaataaga tagacagtat
     4021 agatgatgaa gaaattataa atatggtaat aagagaaaat ttaaattatg aggacttttt
     4081 aataagtacc ttattaactc tatgtcccaa aaaaatagaa atattggatt tgttaaataa
     4141 taattgctca aaggaaatta tagatactgt agaagcaatt tttgaaaata aagttagtat
     4201 aattatggaa aactagaatc taagcatata aaagctatcc atataaaatt aaaaaaattc
     4261 tttttaaatc gacacaaaag acttataatt gtatataaag ctatagtata actagtgtta
     4321 ttaagtataa agaatatcta cttgattaat acaatatagc tggcaaatat acaattgata
     4381 aggagtaatt ttataatgga taatttaatt aggatactga tattagctgt tattggtgga
     4441 tttataggtt atgttacgaa tgtagttgct ataagactga tatttagacc aatagagcct
     4501 attaaaatac ctattttaaa tatagaaata gtaggtctta taccaaagag aagagcagaa
     4561 atagcagcaa atgtaggaga aataattcaa gaagaatttc tttctatgga cgaaatactt
     4621 gcaaatatca ttactgacga agataaggaa gaagttgtaa gatacataaa agcaagggta
     4681 aaaattataa tacatgagaa agtttcattt atcccgagtg gtataaaaaa catgatacaa
     4741 gattatctag gagagataat tgagtctgaa gttaagcaaa gtatagatga attgagtaaa
     4801 aatataataa ataaagcaaa tgaacgtata gatatacaaa aaatggtcga agataagatt
     4861 aatgaactag atttatatga attggaagag ataataataa gaatagctaa gaaagaatta
     4921 aaacatatag agtttttggg gcttgtctta gggtttttaa taggtatagc tcaagggtta
     4981 attactatgt ttatttaaat atatgagaag tagcatttat ttaagtacta attatattta
     5041 cctatttgag tgaattactt attaataaca tttagatatt aattgtattt acctatttga
     5101 gtaaattact tattaatagc atttagatat taattgtatt tacctatttg agtgaattac
     5161 ttattaatag catttagata ttaattgtat ttatttattt gattgtgtta cttattaata
     5221 gtatttaagt atttactgta ctacttatta actatattaa gtattgattg tatttaagta
     5281 tacaaaacct aaaaagagta caaaaattag aagttagttt taataaaaat tagttttagt
     5341 atttatctag tcatatctat catgcatgtg gatacgtttt aaaaatttta aatttatgaa
     5401 aatattataa tatcactata aatcaagaga ttaatttaat ataaaaatat aagaatattg
     5461 gtttacagct gattgagatg aaaaataatg ggtaattaat atattacatt aatgttgatt
     5521 gatgtataac tatctgttat aatgaaaata tattaaaaat catagtgttg aagaggaaga
     5581 gtagagtaga aaccattctc agagaatttg ggtctatggc tgagagccca tgtaataggt
     5641 ctatttgaaa actaccttgg agctgagctt attagcagta tttgttttgt actatacgtg
     5701 aaagtgctcg ggtgacgacc ttatagtcat caagagggtt gtatatactt gtatacgcca
     5761 acttgggtgg aaccgcgaat taatatcgtc ccaaacatat ttggggcgat tttttattac
     5821 aaaaaatcta aaaattattt caataaggag gaaaaaacaa tgattaaagt tgctttaaaa
     5881 gatggctcaa taaaagaatt tgaaaatgct atttctgtta tggatgtagc taaatccatt
     5941 agtgaaggat tagctagaaa tgtggtagca gcgtctgtga acggagaggt tgtaggtctg
     6001 gaccacatta tagatactga ttgtgacttg aatttattta agtttgaaga taaagaaggt
     6061 aaggaagttt ttagacatac atcagcgcat atattagctc aagctataaa aagactttac
     6121 ccagaagcaa agcttgctat aggaccaagt atagaaaatg gattctacta tgatatagat
     6181 ttagaccata gattagttcc agaggaccta gagaaaatag aagctgaaat gaaaaaaata
     6241 gctaaagaag atttaaaaat agaaagattt gaacttccta gaaatgaagc tttagagctt
     6301 atgaaagaac aaggagaaga ctataaggta gaacttatat ctgatttacc tgaaagtgaa
     6361 ataatatctt tctacaagca aggtgatttt actgatttat gtagaggacc acatttacca
     6421 tctactaaaa aggtaaaagc tgttaaatta caaagtgtag caggtgcata ttggcgtggt
     6481 gacgaaaata ataagatgct tcaaagaata tatggaactt cttttgagaa aaacaaagac
     6541 ttagaagagt acttacattt actagaagaa gctaaaaaga gagaccacag aaaattaggt
     6601 aaagaattag gattatttat gatacctgaa gaaggtccag gattccctat gtttttacca
     6661 aaaggtatgg aacttaaaaa tgaattatta aaattctgga gagaaataca cagaaaagct
     6721 ggatatattg agatagaatc tccaatcata ttaaatagaa aattatggga gacttcagga
     6781 cactggtatc attacaaaga aaatatgtat acagttaaaa tagatgatga ggattatgct
     6841 ataaaaccta tgaactgtcc tggtggatta atttactata actctcaact acattcatat
     6901 agagatttcc caatgagagt tgcagagctt ggtagagttc atagacatga gttatctggt
     6961 gcattacaag gattaatgag agttagagca tttactcaag acgattcaca tatattcatg
     7021 ttaccagagc aaattaagga cgaaataaaa ggagtagcta acttaataga tggtatatac
     7081 aaaacttttg gatttgaata taatttagaa ttatctacaa gaccagagaa ctctatggga
     7141 agcgacgaag agtgggaagc agcagaaaat ggattaagag aagctttaga agagttaggt
     7201 ctaccatata ctattaatga gggtgatgga gcattctatg gtcctaagat agacttccat
     7261 ctaaaagatt gtttaggaag aacttggcaa tgtggtacta tccaattaga tatgcaactt
     7321 ccaagacaat ttgataatac ttatattggt caagatggtg aaaagcatag accagttatg
     7381 attcataggg ttgcttttgg tagtatagaa agatttatag gtatattaat agagcattat
     7441 gctggtaaat tcccagtttg gttatctcca actcaagtta agatacttcc tatatctgat
     7501 aaatttatgg attatgcaaa tgaagttaag aaagagttat ttgataaggg tataagagtt
     7561 gaattagatg atagagctga aaaaattgga tttaagataa gagaagctca gcttgaaaaa
     7621 gtgccataca tgttaatagt aggtgaaaaa gaagtagctg ataataatgt ttctgttaga
     7681 tcaagagata aaggtgaaat aggtagtatt aaattagatg aatttatagc tagtatttca
     7741 aaagaaattg aatcaagaga aagtattatt caagactaat atatattatt ttagtagcta
     7801 agatattgtt atataagata agtttaatca atatgttgat atgttgatgc atagtgatta
     7861 aatttatgaa aagatgagta taattagagg tacagttaat catattttta tgattaatgt
     7921 acctctagtt ttttgtatgg tagatttatt aataaatata tcatagaagt gttttgaaca
     7981 tggaaatatt tatgtgcatt ctttaaataa aagtttattt tttgagtgat aattaagtgc
     8041 ttgttggtaa ggttatggtt gtaaaaatca taactttatt ttcatatttg ttccattttc
     8101 ataaaaatta ttatcccttt aagaaaattt cttaatcctc ttgaaatatt tcctttttag
     8161 tctaaagtta aatttctttc ttcaaaatga atatttaaat gaactaaaat ttaagtacat
     8221 tttctaatct tatgagtcta tttttcatag ataattgccc tataatagaa gaatctatgt
     8281 tggagctatg tggtgacaat aacagtattg tcagtgatta attaatgctt tataaatgat
     8341 taattagtgt tttatgttat ttttggactt accctctata catagattaa tttatttaac
     8401 tttagataga gagagaatgt caagtacata cacagacatt agagtttaag aaagtgttta
     8461 tggagcaaga acttttaaaa gaggtagtga cttagtttaa tttcaagaaa tgataaatac
     8521 aaaagaggaa aaagagaggt gttgaaatga tagaaaaagt agaagaaaaa tctaagatta
     8581 ttaaaacatc aaaagaatat aagcgaacta taattgaaga aaaagataaa gaatggacca
     8641 aaaaattaaa tgatatactt agtagaagta gtttttctaa tgatgaatta gataaaatca
     8701 aggcgttaat tccaaaagag attttgacta atgaaaatgt tggagaagtt gtgactgaag
     8761 atggatatgc taagcccgag tatgatgagg tatttaaatc attgttcact ttaaataatg
     8821 aatatgattt acttgtaaat tttataaatg atatcctaaa agatgctcca tatgctaaca
     8881 ggaatatcaa accgttcact caaataaaga gaataattag agttgaaact gacccaacaa
     8941 ttaattacat tggagagaaa agacctagac ttgatatttt ggctgaagat gaagaaaata
     9001 atcatataaa tattgagatg caaagagctt ttgagaacga ttatttggaa agagctgaat
     9061 attatcttag tcgtgtacat ggtagaaagt tagaagaagg taaagagtat aaagaaattg
     9121 gaaaaact
//
LOCUS       DAEQCW010000128         9094 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.129, whole genome shotgun sequence.
ACCESSION   DAEQCW010000128 DAEQCW010000000
VERSION     DAEQCW010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9094)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9094)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9094
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.129"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            77..733
                     /locus_tag="KRO40_003140"
     CDS             77..733
                     /locus_tag="KRO40_003140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093940.1"
                     /translation="MKKGDFIWSGVLICIIAVLAIPSSREVFMEATGAHPYIGGFLKF
                     AVLATMGDLLGARILYKDWKIPVGVFYRAIVWGIIGVVTTYGMSIYSSGVGQAQVDGM
                     LPFEGIAFANALFKSATMNILMSPTVFLFHKIMDCFIDKKYEVGKGIKVKLKDVVNIV
                     DWNAYLGFSVLKTIPFFWIPCHTIVFLFPAEYRVIASAFASIALGLILALANKSKVAV
                     "
     gene            complement(1210..2481)
                     /gene="sleC"
                     /locus_tag="KRO40_003141"
     CDS             complement(1210..2481)
                     /gene="sleC"
                     /locus_tag="KRO40_003141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore cortex-lytic protein SleC"
                     /protein_id="HBH2093941.1"
                     /translation="MQDGFLTVSIIDATNNRPIQNAVVNIYSMSNGSQSSSTLYQNLR
                     SNESGQVTGLVLPAPDVDYSLQPSDVRPYSQYIVEAIADGYETVVIEGTQLLATIEAR
                     QGVPMSPRTRSKRSFSRQSELIFDIGEHTLYGTYPPKIPESNLKPLPPPTGFVVLDNP
                     VVPEFIVVHDGLPEDSSAPNYWIPFKEYIKNIASSEIYSTWPEQTIYANVIAIISFTL
                     NRVFTEWYRNKGYNFTITSTTAYDHKFINNRNLFEPINVVVDAIFNTFIKRPPTSRQP
                     LLAQYCDGQKSQCPDQMTQWGSKDLGDQGYDYESILRYFYGDEIVFERAPIVSGVPVS
                     FPGTTLQVGSSGQYVRTIQNQLNAISNSYPAVPKVIEDGIYGTDTENAVKIFQGIFGL
                     PQSGVVDFKTWYEISRVYVATTRIASLNPLI"
     gene            2726..3442
                     /locus_tag="KRO40_003142"
     CDS             2726..3442
                     /locus_tag="KRO40_003142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HBH2093942.1"
                     /translation="MKLDLFLLAIVPILIGMFWIRSKDRYCREPLIHLIKFFLIGAFL
                     SVIIILLENLLMKFNVFEGYSELIYVSFVVAGLVEEGVKALILIPALIKEKHFTEKLD
                     GIIYSVFLALGFATIENMVYIFSESRNLALQVGINRAVISIPAHVMFAITMGYYISKY
                     KFEGNKNKRREYLFMAVLIPILLHGVFDFILMIEYRWAIILLIVYVIILWKINLDKLE
                     KYMNHSKKVFFGNLRKKKKK"
     gene            3521..4831
                     /locus_tag="KRO40_003143"
     CDS             3521..4831
                     /locus_tag="KRO40_003143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmB/NOP family class I SAM-dependent RNA
                     methyltransferase"
                     /protein_id="HBH2093943.1"
                     /translation="MTELPKEFLEDIEEILKDEYDDFIKSYEESKTTGLRINTLKIDK
                     KKLFDLELFDLNQIPWAEEGFYYDDKIDRPGRNPLHEAGAYYLQEPSAMSVIPKADIK
                     EGEKVLDMCAAPGGKSTYILSKLNDTGLLVSNEINASRIKALGENLERFGARNCIITN
                     TDSNSLRKTFNGYFDKVIIDAPCSGQGMFRKDEVAISDWSYAKVVECQSIQKEIIRDG
                     YKMLKKDGILIYSTCTFSREENEHVINEFISEYPHAELIEMERLWPHKIKGEGHFVAK
                     IKKLEEEECNVKELKIKNLDKEIKDYREFEKKFLKVDFYSNKKNKFYLRGENLYLLPE
                     IYPDTKKLKVLRYGLHLGVLKKNRFEPSHALSHYLKVEDVKNVENFSVQSESILKYLK
                     GDVVNSNDSRGWVLVSVEGIPLGWGKESSGVIKNHYPKGLRKVF"
     gene            4931..5467
                     /gene="lepB"
                     /locus_tag="KRO40_003144"
     CDS             4931..5467
                     /gene="lepB"
                     /locus_tag="KRO40_003144"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH2093944.1"
                     /translation="MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTL
                     VERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGKKKDLVKRVIGVPGDHVKIQDSK
                     VYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTI
                     LGKVLVRLYPFSKIGTID"
     gene            5633..6169
                     /gene="lepB"
                     /locus_tag="KRO40_003145"
     CDS             5633..6169
                     /gene="lepB"
                     /locus_tag="KRO40_003145"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBH2093945.1"
                     /translation="MNETIKEEIVEWIKIIITALFFAFIITRFIKPTLVNGESMYPTL
                     KSHDYLVANRMTYKLSEPKCGDIMIFKTDLLQENGRKKELVKRVIGVPGDHLKIKDSK
                     VYINGKLLNEVSYIHDNYTEGDIDMVIPKGKVFAMGDNREVSLDSRYKEVGLVDEENI
                     KGKVILRVFPFTDIGIFE"
     gene            6179..6934
                     /locus_tag="KRO40_003146"
     CDS             6179..6934
                     /locus_tag="KRO40_003146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIM barrel protein"
                     /protein_id="HBH2093946.1"
                     /translation="MAVGIASLLFNIEEALNICESIKQITHLEIGIDNISECSELCKY
                     KERISKLGLSIGIHLPMELNTCENIEYIRNSWINFIEKIEFELKGFDLRYFNLHLGYV
                     MTNRVRKNRDKYLGNSVDFLDKLNTNSYVCIENTYSKGGDFSNIGNISYDFEYIFKRI
                     KNSKICFCYDTGHCLIDEDAYVKNLKDKIRLIHLSDNDGINDTHVGIGRGILSEEGIK
                     EVLTLDAEYLVLEINYEDIEDTISKLNNIVGEG"
     gene            7008..8675
                     /locus_tag="KRO40_003147"
     CDS             7008..8675
                     /locus_tag="KRO40_003147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside kinase"
                     /protein_id="HBH2093947.1"
                     /translation="MKKINLKIEGKDKEYSLEENSPGIRLGDIAKEFCDEHKGYITLA
                     VVDNKLKELNCRVKKDCEINFLDTTNEDGERVYFRVMSFIFVMACREIFWDSRVTIEH
                     SLSDGLYCEVHIDRKLKEADVENIKNKMKEIVNNDYVIEKIEVTRNEAISIFENNEMY
                     EKAELLKYKEYDSAKVYKCRNYIDHFYGYMLPSTGYIKSFDIKLYNGGVIILGPSEED
                     KTLPMKFVPQPKLSSVYYEAEEWSRLMGIDKVVSLNKIIENNEYGDIIRTFEALHEKK
                     LSQIADMIKDGNKRVVLIAAPSSSGKTSFAHRLSIHLRVNNLNPISISLDDYFIDRKH
                     TPLDEYGNYDFESIYAIDLEKFNLDLKKLLAGEEIDDIRFNFKEGKREYTGKKIKIDS
                     NQPIILEGIHGLNPILTSSIPDEDKFKIYISALTQINLDDHNRIPTADLRMIRRIVRD
                     YNFRGYSADNTILQWASVRRGEKKNIFPYQEEADAIFNSACVYELAVLKRFAKPLLEE
                     IKEDNPAHIEATRLLKFLQYFVELDDTSDIPGISILREFIGGSKIVD"
BASE COUNT         3391 a          930 c         1697 g         3076 t
ORIGIN      
        1 ttgtagatag attgtaaatt aaataaatct ttaatagaaa ggagaactat ttatatatta
       61 aatagtattt ataaatatga aaaaaggcga ttttatatgg agtggagttc ttatttgtat
      121 tattgctgtc ttagcaatac caagtagtag agaagtattt atggaagcaa caggtgcaca
      181 tccatatatt ggaggttttt taaagtttgc tgtattagct acaatgggag atttacttgg
      241 tgctagaatt ttgtataagg attggaaaat accagtagga gtattttata gagcaatagt
      301 ttggggaata ataggtgtag ttaccacata tggaatgtca atctactcat caggtgtagg
      361 tcaagcacaa gtggatggta tgcttccatt tgagggaata gcttttgcaa atgctctatt
      421 taagagtgca actatgaata tactaatgtc accaactgta tttttattcc ataagattat
      481 ggactgtttt atagataaaa aatatgaggt tggaaagggg attaaggtaa aacttaaaga
      541 tgtggtaaat attgtggact ggaatgctta ccttggtttt agtgttttaa aaactatacc
      601 atttttctgg ataccatgtc atacaattgt atttttattc cctgctgagt atagagtaat
      661 tgcttctgca tttgcatcta tagctttagg tctaatattg gctttagcta ataagtctaa
      721 agttgcagtt taggttcact gatgaagata atagtattat ttaaattagg aataactttt
      781 taaattaata ttatttgtat ttataataaa taataattta tataagaagt aatattctaa
      841 gtgatggata gtgttttaaa taataagaag taatactcta agtgatagat agtgttttaa
      901 ataataagga gtaatactct aaatgagaag tatcatttta aataataagt gagattttaa
      961 ataataagta ggtttttcgt tagaatagca ttttattaaa cttaaaaata aatataatat
     1021 tttaaagaaa tctaagttgc taagcactgt ttttaagatt ctaaaaaaac aagttataac
     1081 taaaaaatgg ctgttaagac tacaatactt ataagtaata cttatggtat atattagttc
     1141 ataacagcca tttttatttt aaattaataa ttttattcaa taatttgagt ttatgttcta
     1201 aatcaagctt taaattaaag gatttaaaga agctattcta gttgtagcta cataaactct
     1261 ggatatttca taccatgttt taaaatctac tactccgctt tgaggtaaac caaagattcc
     1321 ttggaatatc ttaacagcgt tttctgtatc tgttccatag ataccatctt ctataacttt
     1381 tggtacagct ggataagaat tagatatagc atttaactga ttttgtatgg ttctaacata
     1441 ctgcccagaa gaaccaactt gtaatgtagt accagggaat gacactggta caccacttac
     1501 tataggcgct ctttcaaata ctatctcatc tccatagaaa tatcttagta tactctcata
     1561 gtcatatcct tggtcaccta agtctttact gccccattga gtcatttggt caggacattg
     1621 ggatttttgt ccatcacaat attgtgctaa tagtggctgt cttgatgtag gaggtctttt
     1681 tataaaagta ttaaaaatag catctacaac tacgttaatt ggttcaaata agtttctatt
     1741 atttataaac ttatggtcgt atgctgttgt tgaagttatt gtaaagttat atcctttatt
     1801 tctataccat tcagtaaaga ctctatttaa agtaaatgat attatagcta ttacatttgc
     1861 ataaattgtc tgttcaggcc aagttgaata tatttcagat gatgctatgt ttttaatgta
     1921 ctctttaaat ggaatccaat agtttggagc tgatgaatct tctggcaaac catcatgaac
     1981 tactataaat tcaggcacta cagggttatc taatacaacg aaaccagtag gaggtggtaa
     2041 tggttttaag ttactttctg gaatcttagg aggataagta ccatatagag tatgttctcc
     2101 tatgtcaaaa atcaactcac tttgtcttga gaaagaacgc ttacttcttg ttctaggaga
     2161 catgggaact ccttgtcttg cttcaattgt agctaacaac tgtgttcctt ctatgacaac
     2221 tgtctcatat ccatctgcta tggcttccac tatatactgg ctataaggtc taacatcaga
     2281 tggttgtaga gagtaatcta catctggtgc tggtaatact aaaccagtca cttgaccaga
     2341 ttcattactt cttaggtttt ggtataaagt tgatgagctt tggctaccat tagacattga
     2401 atatatgttt actactgcat tttgaatagg tctattgtta gtagcatcaa ttatgcttac
     2461 tgttaagaaa ccatcttgca tcaaatcacc ctttctttaa atgaatttag ttcccttata
     2521 tttcaagata tgaatatagc ttaaaatttg ttaaataata tagatataaa tttaaatttt
     2581 tttgagtatt tgagtatatt tgtatttaaa taatttaaaa taatttaatg tatattttag
     2641 tatgtattta aaacacgaat aagttaaaaa taagtagatg atataaatca taaataaatc
     2701 aaaaattttg aaaggaaaat aatctatgaa gctagattta tttttattag caatagttcc
     2761 tatattgata ggaatgtttt ggataaggtc taaagataga tattgtagag aacccctaat
     2821 ccatctaatt aaattttttt taataggtgc ttttctaagt gttataatta tacttttaga
     2881 aaatttactg atgaagttta atgtatttga agggtattca gaactaatat atgtatcatt
     2941 tgtagttgca ggacttgtag aagaaggtgt aaaagctctg atactgattc ctgccctaat
     3001 taaagaaaaa cactttactg aaaagttaga tggtattatt tactctgtat ttttagcttt
     3061 aggatttgca acaattgaaa atatggttta tattttttct gaaagtagaa atctagcact
     3121 gcaagttggt attaataggg cagttatctc tataccagct catgtaatgt ttgcaattac
     3181 tatgggctac tatatttcta agtataaatt tgagggaaat aaaaataaaa gacgtgagta
     3241 tttgtttatg gcagtgttaa ttccaatttt attacatgga gtttttgatt tcatattgat
     3301 gatagaatat agatgggcta ttatattact tatagtttat gtaataattt tgtggaagat
     3361 aaatcttgat aaacttgaga aatatatgaa tcactctaaa aaagtgtttt tcggtaatct
     3421 taggaaaaag aagaagaaat aaaatttaaa ggaaagacat aaataattaa agtataataa
     3481 atgacacaca agtaaagcag attgaagggg gattatagat ttgacagaat taccaaagga
     3541 atttttagaa gatattgaag aaatactaaa agatgaatat gatgatttta taaaaagtta
     3601 tgaggaaagt aagactactg ggcttagaat aaatacttta aaaattgaca agaaaaaatt
     3661 atttgatttg gagttgtttg atttgaatca aataccatgg gcagaagaag gtttttatta
     3721 tgatgataaa attgacagac ctggtagaaa tccactgcat gaggctggag catactattt
     3781 gcaagagcct tctgcaatga gtgtaatacc aaaggcagat attaaagagg gtgaaaaagt
     3841 tctcgatatg tgtgctgctc ctggtggaaa atctacatat atactatcta agctaaacga
     3901 tacaggttta ttggtttcta atgaaattaa tgctagtaga attaaggctc taggggaaaa
     3961 tttagagcga tttggagcga gaaattgtat tataacaaac accgattcta atagcttaag
     4021 aaagacgttt aatgggtatt ttgataaggt tattatagat gcaccttgtt ctgggcaagg
     4081 tatgtttagg aaggatgagg ttgccatatc agattggagt tatgcaaagg tagtagaatg
     4141 tcaatccatc caaaaagaga ttataagaga tggatataaa atgttaaaga aggatggcat
     4201 tttaatttac tcaacttgta ctttttcaag ggaggaaaat gagcatgtta taaatgagtt
     4261 tatcagtgaa tatccacatg cagaacttat tgaaatggaa agattatggc ctcataagat
     4321 aaagggagaa ggtcattttg ttgccaaaat aaaaaaatta gaagaagaag aatgtaatgt
     4381 caaagaatta aaaataaaaa atttagataa agaaataaag gattataggg agtttgaaaa
     4441 gaaattttta aaggttgatt tttatagtaa taaaaaaaat aaattttatt taagaggaga
     4501 aaatttgtac ctacttcctg aaatatatcc agatacgaaa aaactaaaag tattgagata
     4561 tggtttgcat ttaggggttt taaagaagaa tagatttgag ccttctcatg cactatctca
     4621 ttacttaaaa gttgaagatg taaaaaatgt tgaaaacttc agtgtacaga gtgaatcaat
     4681 tcttaaatat ttaaaagggg atgttgtaaa ttctaatgat agtagaggat gggttttggt
     4741 ttcggttgaa ggaatacctt taggttgggg aaaagaatct tctggtgtaa ttaagaatca
     4801 ttatcctaaa ggtcttagaa aagtatttta aactattaga aaaaagaagt ataatattta
     4861 tattgtaggt ttatggtaga ttattttgct gtagattgac ttaatattta acacagagga
     4921 gacgatttta gtgggtgaag cagttaaaaa agaagttgta gaatggataa aagtgattgt
     4981 catagctctt gttttggcat ttgcaataac tcgttttata gtgccaacaa tagtcaaagg
     5041 agaatcaatg tatcctacat tagttgaacg tgattatttg atagttaaca gaattgcgta
     5101 caaggtagga gagccaaaat acaaagatat aatagtattc aaaaccgact taacagagga
     5161 aaatggaaag aaaaaagatt tagtaaaaag agttatcggg gttcctggtg accatgtaaa
     5221 aatacaagac tccaaggtat atgtaaatga taagttgtta gatgagactt cctatataca
     5281 taataatcgt actgatggag atattgatat cgtagttcca gaaggaaaat tatttgcaat
     5341 gggagataat agagaaaaaa gtttagatag tagatacgat gaggttggat tggtcgacga
     5401 gcataccatt ttaggaaagg ttctagtcag attgtatcca ttttctaaga taggaactat
     5461 tgactaaaca tataaaattt ggagcaatcg ctgattagct gaaatcacca gaccatacac
     5521 aatagttgtc tatataaaaa agacaacacc ttatttagta gacttatcta aaagatagtg
     5581 tttaagagac attatcaata aagataatat aactataaag gagaatttgt gaatgaatga
     5641 aactattaaa gaagagattg tagagtggat aaaaataatt attactgcac ttttttttgc
     5701 atttattata actcgtttta taaaaccaac attagtaaat ggagaatcaa tgtacccaac
     5761 acttaaatca catgattatt tggtagcaaa caggatgaca tataagttat cagaaccaaa
     5821 atgtggagat ataatgatat ttaagactga tttattacaa gagaatggaa ggaaaaaaga
     5881 gcttgtaaaa agggttatag gtgttcctgg tgaccatcta aaaattaagg attctaaggt
     5941 ttatataaat ggtaagttat taaatgaagt ttcatatata catgataatt atactgaagg
     6001 cgatattgat atggtgattc ctaagggaaa agtatttgcg atgggagaca atagagaagt
     6061 tagtttagac agtagatata aagaagtggg attagtagat gaagaaaata ttaaaggaaa
     6121 agttatttta agagtatttc cttttacaga tataggtatt tttgagtagg tgatttgtat
     6181 ggcagttggt atagcgtcct tattgtttaa tattgaggag gctttaaaca tttgtgagag
     6241 tataaagcaa ataactcatt tagagattgg aattgacaat atatctgaat gtagtgagtt
     6301 atgtaaatat aaagagagaa tttctaagtt aggattatct atagggatac atttgcctat
     6361 ggaattaaat acttgcgaaa acatagagta tatacgaaat tcatggataa attttattga
     6421 gaagatagaa tttgaactaa aaggatttga tttaaggtat tttaaccttc atttgggata
     6481 tgttatgaca aatagagtta gaaagaatag agacaaatat ttaggaaata gtgtggattt
     6541 tttagataaa ttaaatacaa attcatatgt atgtatagag aatacttatt caaaaggtgg
     6601 ggatttttca aatattggaa atatatctta tgattttgaa tatatattta agaggattaa
     6661 aaattctaag atttgttttt gttacgatac tggacactgt ttaattgatg aggatgctta
     6721 tgtaaagaac ttaaaggata aaataagact gatacactta agtgataatg atggtatcaa
     6781 tgatacacat gttggtatag gaagaggaat tttatctgaa gaggggatta aagaggtctt
     6841 aacattagat gcagaatatt tagtattaga aataaattac gaagacattg aagatactat
     6901 aagtaaattg aataatattg taggagaggg ttaaatacct ctctttatct tgttgatatg
     6961 cctcattaat taaaatttat attcatcaaa aggaaggaga tgttgaagtg aaaaaaataa
     7021 acttaaaaat agaaggaaaa gataaggaat attcattaga agaaaattcc cctggaatca
     7081 gattgggaga tatagcaaaa gaattttgtg atgagcataa gggttatata acacttgcag
     7141 ttgtagacaa taaactaaaa gagctaaatt gtagagttaa gaaggattgt gagataaatt
     7201 ttttagatac tactaatgaa gatggagaga gagtttactt tagagtcatg tcatttatat
     7261 ttgtaatggc atgtagagaa atcttttggg atagcagagt tacaatagaa cattcactat
     7321 cagatgggct atattgtgaa gttcatatag atagaaagct taaagaagca gatgttgaaa
     7381 atataaaaaa caagatgaaa gagatagtaa acaacgatta tgttatagaa aaaattgaag
     7441 ttacaagaaa tgaagctatt tctatctttg aaaataatga aatgtatgaa aaggcagagc
     7501 ttttgaaata caaagagtat gatagtgcta aagtatataa gtgtagaaac tatatagacc
     7561 atttttatgg ttatatgttg ccatcaactg gttatataaa atcatttgat attaagcttt
     7621 ataatggagg cgttataatt ttaggaccta gtgaagaaga taagactctt cctatgaaat
     7681 ttgtacctca acctaagcta tcaagtgtat attatgaagc agaagaatgg tcaagactta
     7741 tgggaattga caaggtagta tctcttaata aaataataga aaacaatgaa tatggagata
     7801 taataaggac atttgaagca ttgcatgaaa agaagttatc ccaaatagcg gatatgataa
     7861 aggatggcaa taagagagta gttttaatag cagccccatc ttcatctgga aaaacaagtt
     7921 ttgctcacag attatcaata catcttagag taaataattt aaatcctatt tcaatttctt
     7981 tagatgatta ttttatagat agaaaacata ctcctttaga tgaatatgga aattatgatt
     8041 ttgaatcaat ttatgcaata gatttagaga agtttaactt agacttaaag aaacttttag
     8101 ctggtgaaga aattgatgat ataagattca attttaaaga aggtaagaga gaatacactg
     8161 gtaaaaagat aaagatagat tcaaatcagc caattatatt agaaggtata catgggctaa
     8221 atcctatttt aacatcatct ataccagatg aagataaatt taagatatac ataagtgccc
     8281 ttactcaaat aaatttggat gaccataatc gaatccctac tgctgatttg agaatgataa
     8341 gaagaattgt tagagactat aattttagag gatatagtgc tgataatact attttacaat
     8401 gggcatcagt tagaagagga gaaaagaaga atatattccc gtatcaagag gaggcagatg
     8461 ctatatttaa ctctgcttgt gtatatgaat tggcagtttt aaaacgattt gcgaaacctt
     8521 tgttggaaga aataaaggaa gataatcctg cacatattga agctactaga ttactaaagt
     8581 ttttgcagta ttttgttgaa ttggacgata cttctgacat accaggcatt tcaattctta
     8641 gggaatttat tggaggaagt aaaatagttg attaatgtgt gtattataga ttgttttatg
     8701 aagattaaat ggcatagcaa gtagtgtgat tggtttatgt taagtatatt aagtgtaaag
     8761 tggagaatta aattgataca gattttaaag tttgagttga tatataaaaa ggcttgtttt
     8821 atacttttgt atgaagcaag ctttttattt taaattttac ttttttgttt aatattttgt
     8881 tagtttatgt gattattttt taaaagagta aaagagtaaa agagtaaaag agtaaaagag
     8941 taaaagagta aaagagtaaa agagtaaaag agtaaaagag taaaaggtgt tgggttagaa
     9001 atttttggtg ttataaaaat ttaaattact ggattattag attgctggat tgctaaatta
     9061 ctaggttgtt aaattattga attattaggt tgtt
//
LOCUS       DAEQCW010000129         8917 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.130, whole genome shotgun sequence.
ACCESSION   DAEQCW010000129 DAEQCW010000000
VERSION     DAEQCW010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8917)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8917)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8917
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.130"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(525..1604)
                     /locus_tag="KRO40_003148"
     CDS             complement(525..1604)
                     /locus_tag="KRO40_003148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2093948.1"
                     /translation="MILITLCILVAVFVLAFAGLRLIAPTIIRTSHKIEAPGIDRMEM
                     VEIGGIQQALYIRGQNADNPIILWVHGGPGNSMMPFLHLYQYEWENDFTVVNWDQRNV
                     GKTYFANDPAAVLQTMSAERVLQDVHEVTAYLKQEFNKEKIILIGHSWGTVLGTMAVQ
                     TYPEDYSAYIGIAQTVNMVDNERVGYEKTLEMVKAAGKQKDIKALEAIAPYPPAKYGP
                     SYLAALMTVRTYQSKYGLSINMDLGNIISILATPYYSLRELKNTAIVNQNAIDNQGDV
                     LRFLVEEADIRNYGVDYQVPVYYIMGENDYNSPYLPAKKFFDEIVAPDKQIFFIPDAD
                     HLPFLSKKAEFDCVLLEEIAPKLAK"
     gene            complement(1688..2344)
                     /locus_tag="KRO40_003149"
     CDS             complement(1688..2344)
                     /locus_tag="KRO40_003149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093949.1"
                     /translation="MTRKNNPKQAIENIITISAKLFAEKGYDKTSMQNIVDASGMSKG
                     GIFHHFSSKEDIFNVVMERRFEQIIETVNQWLGEMHGLTAKEKLRSLVRRHLTDEVIK
                     ESSNMITSAIESPHIILAFTQDNLKKLAPILANVLREGIEDRSIITEFPDECAEVILL
                     LFNFWCDTDVFQGDFPTLRKRFQFLQFLMRQIGVDILEDEIIESINIFYERKPMGQVE
                     "
     gene            2666..2872
                     /locus_tag="KRO40_003150"
     CDS             2666..2872
                     /locus_tag="KRO40_003150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093950.1"
                     /translation="MISHAAEICKKYKMPFIIFPTIEKKSIEEWVNIGANMLCLAQDT
                     TFITYVINQLLSFYNEIVPIQKQH"
     gene            complement(3025..3453)
                     /locus_tag="KRO40_003151"
     CDS             complement(3025..3453)
                     /locus_tag="KRO40_003151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBH2093951.1"
                     /translation="MSKIYIVYWSGTGNTEKMANFVAEGVKLKGKTPEVLDVSLLKPS
                     DLKEEDKFALGCPSMGAEQLEEGYMEPFVSELESMVSGKQIGLFGSYGWGNCEWMRDW
                     EERMQNAGATIIGGEGITAMEDPNEEAKDECIELGKTLAE"
     gene            complement(3929..4867)
                     /locus_tag="KRO40_003152"
     CDS             complement(3929..4867)
                     /locus_tag="KRO40_003152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBH2093952.1"
                     /translation="MNKRMKLIPYEINENLRGAKNKFPYGIKQMNARGMWDEGYTGKN
                     IVVGIIDTGCDISHPLLKGKIIGGANFSDDSNGNKNIYEDFNGHGTHVAGIIAASNYN
                     NEVMGVAPDCKLLIAKALNKDGTGTYQSIINAINFAVNNKVDIISMSLGGNKDDKNLK
                     NAVMQAVKNNISVVCAAGNNGDGDSSTSEYSYPASYAEVIEVGAINENYLVEKFSNSN
                     TTIDLVAPGRNIISTYMDNKLAIMSGTSMSAPYVSGSLALIKEWAREEFERDLDEAEL
                     YAQLIKCTRALGIPRTEQGNGYLYLNLYKYKNNGKR"
     gene            complement(5381..6193)
                     /locus_tag="KRO40_003153"
     CDS             complement(5381..6193)
                     /locus_tag="KRO40_003153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2093953.1"
                     /translation="MFYNAKSCQMMIGSNTVNYIEFGSGKKTLIILPGLGDGLFPLHG
                     KIQAIAFAFRYKQFTKDYKVYVFSRKNQITEKYSTRDMAKDQADIMKKLGIMKAEVMG
                     VSQGGMIAQYLAIDYPELVEKLVLAVTSSKQNDTIQNVICSWINMAKKQNYNDLMIDT
                     AKKSYSERYLKKYQLFIPFLGKVGKPKDFKRFIIQATSCIEHNAFSELNKITCPTLII
                     GGANDKIVGNNASFHLVEKIKKSEIFIYEGLGHATYEEAQDFNERVLEFLNK"
     gene            complement(6216..6848)
                     /locus_tag="KRO40_003154"
     CDS             complement(6216..6848)
                     /locus_tag="KRO40_003154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2093954.1"
                     /translation="MNREEKSKNSKEKIIQSAFSLFSSKGYDSTSTQDIINLSGLSRG
                     AMYHHFKTKEDILRSVTKELYSQMNNFLEHLVADDTLTANEKIIELVVHSANDYTRRK
                     MVHCSWLEKIPFALIEEVRNLNNVVAPNIAKIIKQGVENKEFSCEYPEELAEMLVFSI
                     DILLDPVLFKREYSEVCNRLDFLLFMLKKMDIPLIDEYGIQKFKDLFRQL"
     gene            complement(7192..8847)
                     /gene="ilvD"
                     /locus_tag="KRO40_003155"
     CDS             complement(7192..8847)
                     /gene="ilvD"
                     /locus_tag="KRO40_003155"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020457899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HBH2093955.1"
                     /translation="MRSDIKKGIEGAPKRALMYGMGLTKEEIERPLIGIVNAQNEVIP
                     GHLHLDEIAEAAKNGVRMSGGLPLEFPAIGVCDGIAMGHVGMNYSLASRELIADSIEA
                     MAMAHGFDALVLIPNCDKIVPGMLMAAARLNIPSIVVSGGPMLPGKKNGKVYDFNSAM
                     EGVGACKDGTVSEEELEALAMNSCPGCGSCSGLFTANSMNCLTEALGMGIPYNGTAAS
                     HSGERKRIAKYAGMYVMELLKNDIKPRDILTIDAFKNAIAVDMAMAGSTNTVLHLPAI
                     AYESGIELNLDFFDEISEKTPCLTKLSPSGKHHIEDLHMAGGIPAIMNELSKINGINL
                     DCKTVTGKTIGENIRNCEIENEEVIHTLKNPYSNQGGLAILKGNLALNGAVVKKSAVA
                     EEMLVHEGPARVFNSEEEAVNAIFGKKINKGDVIVIRYEGPKGGPGMKEMLSPTSAVA
                     GMGLDKYVALLTDGRFSGATRGASIGHISPEAMEGGLIGLVEEGDIISINIPDKKLEL
                     KVDEVEIENRKLKFKPLEPKIKHGYLSRYAKLVTSANTGAVLK"
BASE COUNT         2738 a         1740 c         1089 g         3350 t
ORIGIN      
        1 aattcaatag taagtggaat aaaattttat atgaataaga acattataaa aatactttat
       61 acaatagtca ataaaagata ttagcttcaa attatgttaa agttgtatta tttaaagtga
      121 aaaaacaaat aaaaaagaaa taatagtata agtagaaaaa tatacttaaa acaaggcgaa
      181 gcctctcttg tatctaaatc aagtagagaa ttaaatctaa aaaagaaaat aaatataaaa
      241 gatgactcct gtacattaca agaatcatct tatggtttca taatcactcc atggttttta
      301 actgtctgat ataaaggtct cagttcactc atagcatgac caccctttcc gattgctgac
      361 cccgtcactt atggacaaaa tgtccataag tgatagtcct ctcttaaaac cctctaaata
      421 gatatatctc aagcacctca ttgaaaccag ttgctggaaa caaactgaag cgttctggaa
      481 tagtaaaaga aattgccacc atatccacgt tactgtccta gttgttactt tgctaacttc
      541 ggagcaattt cctctaacaa tacgcagtca aattctgcct ttttgctaag aaatggcaga
      601 tggtctgcat ctggtataaa aaaaatctgt ttgtctggcg ccactatttc atcaaaaaat
      661 ttcttcgctg gaagataggg gctattatag tcattttctc ccatgatgta gtatacaggg
      721 acctgatagt caactccata atttcttatg tcagcttctt ccactaaaaa ccgcaataca
      781 tcaccttgat tgtcaatcgc attttgattg acaatggccg tattttttaa ctctctcaat
      841 gaataatacg gggttgccag tatactgatt atattgccca aatccatatt tatagaaagc
      901 ccatacttgc tttggtatgt tcttactgtc ataagagctg ccaaatagct tggaccatat
      961 tttgctggcg gatatggtgc aatagcttcc agcgccttga tatctttttg cttccctgca
     1021 gctttcacca tttcaagtgt cttttcatag cccacgcgct cattgtccac catattaacg
     1081 gtctgcgcaa tcccaatgta cgcgctgtaa tcctccggat aggtttgcac agccatagtt
     1141 cccagcactg ttccccagct atgacctata aggataattt tctccttgtt gaactcttgc
     1201 ttcaaatatg ctgtcacctc atggacgtct tgcagaacac gctccgcgct catggtctgc
     1261 aaaactgctg ccggatcgtt cgcaaagtat gttttgccta cgtttcgctg atcccagttc
     1321 accacagtaa aatcattttc ccactcatac tggtacagat gtaaaaatgg catcattgaa
     1381 ttaccaggac ccccatgaac ccaaaggatg atggggttgt ctgcgttttg tccccggata
     1441 tataacgcct gctgtatgcc gccgatctcc accatttcca tgcggtcgat tccaggagct
     1501 tctattttat ggcttgtacg tataatcgtg ggggctatca gacgcaaacc ggcaaacgcc
     1561 agaacaaaaa cagcaactag tatgcaaagt gtgattaata tcattttaag taccttcttt
     1621 catgaatttt tttagccata gatatctcct ctaacattaa aaaaaatatg ttgctatttt
     1681 agttttgtta ctctacctgt cccattggtt tcctttcata aaaaatatta attgattcta
     1741 taatctcatc ttccaggata tcaactccta tttgtctcat aagaaactgt aagaattgaa
     1801 accgtttacg aagtgtagga aagtccccct gaaatacatc tgtatcacac caaaagttaa
     1861 agagcagcaa aattacctct gcgcattcat ctgggaactc tgtgatgatg cttctatcct
     1921 ctatgccttc tcgtaaaaca tttgctaata ttggtgctag ttttttcaaa ttatcctgtg
     1981 taaatgccag tatgatatgc ggactttcta tagcgcttgt aatcatgtta ctagattctt
     2041 ttatcacctc atccgttaaa tgccgcctaa ctaaacttct aagcttctct tttgctgtaa
     2101 gtccatgcat ttcaccgagc cattgattta ctgtctctat tatctgttca aagcgccttt
     2161 ccatgaccac attaaaaata tcttcttttg aactgaagtg atgaaaaatt ccgccctttg
     2221 acattcccga agcatcaaca atattttgca tacttgtttt gtcatatcct ttttcagcaa
     2281 acaattttgc agaaatggta atgatatttt caatagcttg ctttggattg ttctttctag
     2341 tcattatata actccttctt attaaaaacc gactgttggt ttttattata taagctattc
     2401 ctacttctgt caagcaacat tatgtttatg gcaaaacaat aaggtttggt ggttagacag
     2461 gtattaatta gactaatgcg actttcccct agatggaacc cttggtaaat ttgcaatctt
     2521 taccggcttt gattatatct gtaagcaagg caggtatggc cacacctgcc ctgtttgacc
     2581 ctcggatatt cattcctatc ccttctctcc ttagccatta caccaaaacg ccgctcattg
     2641 tctccaatgg cggcgtttta aagatatgat ttctcatgct gctgaaatat gcaaaaaata
     2701 taagatgccc tttattattt ttcctacaat agaaaagaaa agtattgaag aatgggttaa
     2761 tattggagca aatatgcttt gtttggcaca agatactacc tttatcactt atgttatcaa
     2821 tcaattatta tctttttata atgagattgt accaattcaa aaacaacatt aaattataaa
     2881 tctaatttta tattaaaaga gactaatatt ttatctatct ctgttaagga tattttctta
     2941 tgtatcataa tattagtctc tcttattatt atatactgct atcatcatta gttgctattt
     3001 atactatttt tataatatac aaatttattc agctaacgtt ttgcctaatt ctatacactc
     3061 atcttttgct tcttcatttg ggtcttccat tgctgtaatt ccttctccac caataattgt
     3121 agcaccagca ttttgcatac gttcttccca gtctctcatc cattcacaat ttccccatcc
     3181 atatgaacca aataatccaa tctgtttacc tgataccata gattctaatt ctgaaacaaa
     3241 tggctccata tacccctctt ctagttgctc tgctcccata gatgggcaac ctaatgcaaa
     3301 tttatcttct tcttttaaat cacttggttt cagtaagctc acatctaaaa cttctggtgt
     3361 cttacctttt aacttcacac cttcagccac aaaatttgcc attttttcag tatttcctgt
     3421 tccactccaa taaacaatat atattttact catttttacc tcctgtagta ttttttaatt
     3481 aatcaatagt tagttatagc taactaacat ctaaaaaaca aaagatttct ttatctgaaa
     3541 tctctttatt tttctaaata tagaatatca tagttgattt tgaaattcaa tgcttattga
     3601 taatatttat catttatatt ttatattcat tttataatat caaaacactg catcgtattt
     3661 ctaatctttc atagaaaaat ttctaactta tagtactttt gcatctctta taaatctttt
     3721 atatgtataa gtacatagaa aaacacacct tttccagatg tgctatctat aatatcgtat
     3781 atttattttt caattttaac tagctaatat gtttataaat tttatcactt aataccttta
     3841 tacattgatg taaaatctta cacctaagta atttttatta tttgtctcga ctctatataa
     3901 tatagctatt ttatcatcaa atcaaaaatt atcttttgcc attattcttg tatttataga
     3961 gatttaaata taagtatcca tttccttgtt ccgttctagg tattccaagc gctctcgtac
     4021 attttattaa ttgtgcatac agttcagctt catctaaatc tctttcaaac tcctctcttg
     4081 cccattcttt aattagtgct aatgagcctg atacgtatgg tgcactcata ctggtaccac
     4141 tcataatagc aagtttatta tccatataag tcgatataat atttcttcct ggagctacca
     4201 aatctattgt agtatttgaa ttactaaact tttcaaccaa atagttttca tttattgcac
     4261 ctacttctat tacctcagca taactggctg gataactata ctcacttgta ctagaatcac
     4321 catctccatt attacctgct gcacacacta cagaaatatt attttttact gcttgcatga
     4381 cagcattttt taaattctta tcatctttgt ttccaccaag agacatagat ataatatcaa
     4441 ccttgttatt tacagcaaag ttaatagcat taattatact ttgatatgtt ccagtaccat
     4501 ctttatttaa tgcttttgct attaataatt tacaatctgg agctactccc ataacttcat
     4561 tattatagtt agatgcagct ataatacccg ccacatgagt tccatgacca ttaaaatcct
     4621 catatatatt tttatttcca ttactgtcat cactaaaatt tgcaccacca attatttttc
     4681 cttttaaaag aggatgagat atatcacaac ctgtatctat tataccaact acaatatttt
     4741 taccagtata accttcatcc cacattcccc tagcattcat ttgttttatt ccatatggga
     4801 atttattttt tgcacctctt agattttcat ttatttcata cggaattagt ttcattcttt
     4861 tattcatcat atatcctcct aaaaatttta ttgcttataa aaatcatgaa ttttatttta
     4921 taataggttt ataaatcaaa ttaaaaccta tatctactta tttatattta tgatatattt
     4981 tttattttta ggagtcatat tttattgtat ataaaataat atttagataa ctatattaaa
     5041 aaatacatgt ttgcttatat acaaaactta ctaaaatgtc tttaatattt ttgtatacaa
     5101 acattatatt ttttatataa aaagctcata aaaattttga ttatattttc ataagttaac
     5161 aaatgtgggt ataatatgaa tttacaaaat tcctctgttt gtataagtgc tttaccaata
     5221 caacaatata taatcacatt gaagctatat ttgtatttat agtagataat gtatcaaaaa
     5281 ttggttatga atagtaaaaa taccagttaa gcatattttc atgtttctat ttttaacatt
     5341 aaatttccaa tcttcatatg tatattttta acaaaggtgt ttacttattt aaaaactcta
     5401 aaactctttc attaaaatcc tgtgcttctt catatgtagc gtgtcccaat ccctcataga
     5461 taaatatttc gcttttttta attttttcta ctaaatgaaa agaagcatta tttccaacaa
     5521 ttttatcatt agcacctcct ataattaagg ttggacatgt tattttattt aattcggaaa
     5581 aggcattatg ttctatgcaa gaggtcgctt gaataataaa tcgtttaaaa tcctttggtt
     5641 tacctacttt tcctaaaaaa ggaataaata attggtattt ttttaaatat ctttcagaat
     5701 aggatttctt tgctgtgtca atcattaaat cattgtaatt ctgcttcttc gccatattaa
     5761 tccaactaca aataacattt tggatagtat cattttgctt tgaagaagta actgccaaca
     5821 caagtttctc aactaactca ggataatcaa ttgccagata ttgagctatc attccacctt
     5881 gagaaacacc cattacttct gctttcataa ttccaagttt tttcattata tctgcttggt
     5941 ctttagccat atcccttgtg gaatattttt ctgtaatttg attttttcta ctaaatacat
     6001 aaaccttata atcttttgta aattgcttat atctaaaagc aaaagcaatc gcctgtattt
     6061 ttccatgtaa aggaaataaa ccatctccta atcctggtaa aataattagt gtcttcttac
     6121 cactaccaaa ttcaatataa ttcactgtat tacttcctat catcatttga caactttttg
     6181 cattataaaa catagtctat tcctcgcttt tcctattata attgtctaaa taaatcttta
     6241 aatttttgaa taccatactc atcaattaga ggaatatcca ttttttttaa catgaataat
     6301 aaaaaatcca acctattaca tacttcactg tattcacgtt taaataatac agggtcaagt
     6361 aaaatatcaa tactaaaaac gagcatttca gctaattcct ctggatattc acaagaaaat
     6421 tctttatttt caacaccttg tttaattatc ttagcaatat tgggtgcaac tacattgttg
     6481 agattacgaa cttcctctat taaagcgaat gggatttttt ctaaccagct acaatgtacc
     6541 atttttctac gtgtgtaatc attcgcacta tgaacaacca attctattat tttttcattt
     6601 gctgtaaggg tgtcatcagc aacaagatgc tctaaaaaat tattcatttg tgagtaaagt
     6661 tcttttgtga cacttctcag tatatcttct ttagttttaa agtgatgata cattgcacct
     6721 ctagatagac cagataaatt gataatatct tgtgtagatg ttgaatcata tcctttagac
     6781 gaaaatagtg aaaatgctga ttggataatt ttttctttac tatttttact tttttcttct
     6841 ctattcatat ttccctccta aaaacagact gtctgtttgt ttttcattat acattttaat
     6901 atttattatg tcaagaatta actgactttc aatttcttca tagtttagat ggaacgaaaa
     6961 gcattccaca tcaaactttt aaaaagttgt attccctcaa caaggtctaa aagatacatc
     7021 tctatgctgt actcgtattc cttataatag agatgtattg ttttcaaaga taatcaagat
     7081 tttgctgtgt ttttcataca aaataaaaag gatacctcat tagtgctata acacctaaga
     7141 tatccaatta atattttctt aactttttct aatttacata aatatagtct actattttaa
     7201 aactgctcct gtatttgctg atgttaccag tttagcatat ctacttaagt atccatgctt
     7261 tattttcggt tctaaaggtt taaattttaa ttttctattt tctatttcaa cttcatctac
     7321 ttttaactct aattttttgt ctggtatgtt tatagaaatt atatctcctt cttcaactaa
     7381 cccgattaaa ccaccttcca tagcttctgg agaaatatgg cctatagatg ctcctctagt
     7441 tgctcctgaa aaacgaccat cagtaagaag tgctacatac ttatcaagtc ccattcctgc
     7501 aactgctgat gtaggagata gcatttcttt cattcctgga ccaccctttg gaccttcata
     7561 tcttataact ataacatcac ctttgtttat ttttttacca aaaatagcat ttacagcttc
     7621 ttcttctgaa ttaaaaactc ttgctggtcc ttcatgaact aacatttctt ctgcaactgc
     7681 tgactttttt acaacagctc catttagagc aagatttcct ttcaatattg caagtccacc
     7741 ttggttacta tatggattct ttaatgtatg tattacttct tcattttcta tttcacaatt
     7801 tcttatattt tcccctatag tcttgcctgt tacggttttg caatctaaat ttattccatt
     7861 tatctttgaa agttcgttca ttatagctgg tattcctcct gccatatgta aatcttcaat
     7921 atgatgtttt ccacttggac ttaattttgt taaacaagga gttttttcac ttatttcatc
     7981 aaaaaaatct aagttaagct ctattcctga ttcataagct attgcaggta agtgaagtac
     8041 tgtatttgta gagccagcca ttgccatatc cacagctata gcatttttaa aagcatctat
     8101 tgttaaaata tctctaggtt ttatgtcgtt cttaagtaac tccataacat acatacctgc
     8161 atattttgct atcctttttc tttctccaga atgtgacgca gcagtaccat tatatggtat
     8221 acccatgcct aaagcttctg ttaaacaatt catgctattt gctgtgaaaa gaccagaaca
     8281 tgaaccacat ccaggacaag agttcatggc taacgcttct aattcttctt cacttactgt
     8341 tccatcttta catgctccaa caccctccat tgcagagtta aaatcatata cttttccatt
     8401 ttttttacct ggaagcatag gccctccact cacaacaata cttggtatat taagtcttgc
     8461 agcagccatt aacatacctg gcactatctt gtcacaatta ggtataagta ccaaagcatc
     8521 aaaaccatgt gccatagcca tagcttctat tgaatctgct attaattctc ttgaagccag
     8581 ggaataattc attccgacat gccccatagc tataccatca cataccccta tagcaggaaa
     8641 ttctaatggc aaaccaccac tcattcttac tccatttttt gcagcttctg ctatttcatc
     8701 aagatgcaga tgaccaggaa tcacctcatt ttgtgcattt actataccta ttaatggtct
     8761 ttcaatttct tctttagtaa gacccattcc atacattaac gctctctttg gagctccttc
     8821 tattcctttt tttatatcac ttctcataat attacctctt tcttactttt ttaaattttc
     8881 ataatattat tataatatat ttttctatta attaatt
//
LOCUS       DAEQCW010000130         8882 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.131, whole genome shotgun sequence.
ACCESSION   DAEQCW010000130 DAEQCW010000000
VERSION     DAEQCW010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8882)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8882)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8882
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.131"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            84..1289
                     /locus_tag="KRO40_003156"
     CDS             84..1289
                     /locus_tag="KRO40_003156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBH2093956.1"
                     /translation="MSKKVLIMSASTGGGHNRAALAIKEELTSKTLDGEPIECEIIDS
                     LKLVNNTMDKIISRGYEKSAIYTPKAYGSVYRLSETNLLSKNEFKDNLLITFMAKKFK
                     KLIRSEKPDLIIGTHPFPMIALSTLKKNFNLHNNESNAYTEHFYKHYTNTINVPPLIS
                     VLTDYTTHSTWIQNEIDYYIVGHEYVKELLVFDGVEPSKIRTFGIPVEKSFLSHRDKG
                     IVLSELNLSPDKLTVLLMGGSFGAGNIKETLDELLDTDRDFQILVITGKNESLKEKIE
                     KKLMSRYHDKNVCVLGYTDKMNDILASIDVLVSKPGGLTTTEALLKDVPMIVPYYIPG
                     QEEENLDFLSNCGAALRTTKKYNLSILLKVLIDDPSRLEMLKRNIKSIRKSNSAQNIA
                     NLILNIISG"
     gene            complement(1360..1581)
                     /locus_tag="KRO40_003157"
     CDS             complement(1360..1581)
                     /locus_tag="KRO40_003157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093957.1"
                     /translation="MKPIMNLEEHNAMKEKRVKKMKSKDKPKYDDFEDISFSNKKKTK
                     KNVRNKNAEFRNNYKNYQYDYEEDFYEPI"
     gene            complement(1722..2321)
                     /gene="recR"
                     /locus_tag="KRO40_003158"
     CDS             complement(1722..2321)
                     /gene="recR"
                     /locus_tag="KRO40_003158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012634696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HBH2093958.1"
                     /translation="MQVYTGPITRLIEEFSKLPGVGRKTAQRLAFHIINMNTNDVEAL
                     SKAIIDAKREIRYCSICCNITDTDPCSMCSNKSRDSSVICVVEDPRDVAAMERTREFK
                     GQYHVLNGVISPMDGIGPDMLKIKELIQRLGNQEVKEIIMATNPTIEGEATAMYIARL
                     VKPMGIKVTRIAHGLPVGGDLEYADEVTISKALEGRREI"
     gene            complement(2334..2684)
                     /locus_tag="KRO40_003159"
     CDS             complement(2334..2684)
                     /locus_tag="KRO40_003159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HBH2093959.1"
                     /translation="MAKKGFGGGMMPGGGNMNNLLKQAQKMQENMQKAQQELESKEVE
                     ASVGGGAVTVKVNGKKEVIDITIKPEVVDPDDIEMLQDLVLSAVNQALRNIDDIQASQ
                     MSKVTGGMNIPGLF"
     gene            complement(2743..4380)
                     /gene="dnaX"
                     /locus_tag="KRO40_003160"
     CDS             complement(2743..4380)
                     /gene="dnaX"
                     /locus_tag="KRO40_003160"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HBH2093960.1"
                     /translation="MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCG
                     TRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICESVLKDNTMDVVEIDAASNNSVDD
                     IRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
                     IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALS
                     ILDQCMSFGESKIDYKDVVELMGSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKD
                     IRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKNIDINDLIRILNILS
                     ITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGN
                     NKEKEYEVDREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEV
                     KSFNVYSNMLYVIFDDKFDFAKTRLSSQDTINYLEKTIRDVLNRSFNVKIVLTSEVKD
                     INLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK"
     gene            complement(4457..4721)
                     /gene="ffs"
                     /locus_tag="KRO40_003161"
     ncRNA           complement(4457..4721)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="KRO40_003161"
                     /product="signal recognition particle sRNA large type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01854"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF01854"
     gene            complement(4759..4850)
                     /locus_tag="KRO40_003162"
     tRNA            complement(4759..4850)
                     /locus_tag="KRO40_003162"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(4814..4816),aa:Ser,seq:gga)
     gene            complement(4851..5306)
                     /locus_tag="KRO40_003163"
     CDS             complement(4851..5306)
                     /locus_tag="KRO40_003163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HBH2093961.1"
                     /translation="MESSFYMKEALKEAYKAYNKKETPIGAIIVKDNQIIARAHNLTE
                     TLKDSTAHAEILAIKQASEKLGGWRLTDCDLYVTMEPCIMCSGAIVNSRIKKLIIGTR
                     HVKNSYIEKQHEFKLDYFNNNNVKVAFDVLQEECSIILQEFFKALRKRD"
     gene            complement(5627..6898)
                     /gene="serS"
                     /locus_tag="KRO40_003164"
     CDS             complement(5627..6898)
                     /gene="serS"
                     /locus_tag="KRO40_003164"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBH2093962.1"
                     /translation="MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQE
                     VEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELSDKIKGIDEKVKEVEAKMEYTLM
                     RIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
                     SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDM
                     FKIEGLEYFLIPTAEVPVTNIHANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVVKICTGDLGFTAAFK
                     YDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRC
                     LAAILENYQQADGSVVVPEELRPYMGVDVIK"
     misc_binding    complement(7024..7229)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(7357..8238)
                     /locus_tag="KRO40_003165"
     CDS             complement(7357..8238)
                     /locus_tag="KRO40_003165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBH2093963.1"
                     /translation="MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVI
                     GIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYISMLSIISLISLGIIGIQTTSVVA
                     VLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
                     TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSILNEIFTNEKR
                     ILNDPKPIIGLNSIGNNTMQIVARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVP
                     SSLLFNNTGNLNTMDKR"
     gene            complement(8250..8759)
                     /locus_tag="KRO40_003166"
     CDS             complement(8250..8759)
                     /locus_tag="KRO40_003166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HBH2093964.1"
                     /translation="MNSNERRSKLIDILKESKHPVKGGTLAELLNVSRQVIVQDIALI
                     RARGFEIIATPQGYIIYNQPYFTKQIKCKNHKDSKEIYDELKIIVDLGGIIKDVIVNH
                     PTYGQITAELNIYSKMDIDNFMKKVETNEFKQLSVLTECSHIHTIEAIKEETIEAIVK
                     ELKDNGILS"
BASE COUNT         2843 a         1565 c          958 g         3516 t
ORIGIN      
        1 atcaataacc ttattcacaa agacagtttt tatatatcaa aatataatat aaatactatg
       61 ctacatttta ggaggatttt attatgagca aaaaagtatt aataatgtct gcttccactg
      121 gtggtgggca taatagggct gctctagcta ttaaagaaga acttacttcc aaaacacttg
      181 atggagagcc aattgaatgt gaaataatag atagtttgaa attagttaat aatacaatgg
      241 ataaaataat ttcaagagga tacgaaaaat ctgctatata tactcccaaa gcctatggaa
      301 gtgtatatag attatctgaa acaaatcttt tatcaaaaaa tgaatttaaa gataatctac
      361 taataacatt catggctaaa aaatttaaaa aacttattag aagcgaaaaa ccagacttga
      421 ttataggaac gcatcctttt ccaatgattg ctctaagtac attgaaaaaa aactttaatt
      481 tacataataa tgaatcaaat gcttacacag agcattttta taaacattat acaaatacca
      541 ttaatgttcc tccgcttatt tctgtattaa ccgattatac tactcattct acatggatac
      601 aaaatgaaat tgattactat attgttggtc atgaatatgt aaaagaatta ttggtgtttg
      661 atggagttga accgagtaaa attagaacat ttggaatccc tgttgaaaaa tcttttctct
      721 ctcacagaga taaaggtatt gttctttctg agttgaattt atctcctgat aaattaactg
      781 ttttacttat ggggggtagc tttggggctg gaaatataaa agagacactt gatgaattac
      841 tggatactga tagagacttt caaatacttg taattactgg taagaatgaa agcctaaaag
      901 aaaaaatcga aaaaaaactt atgtctcgtt atcatgataa aaatgtatgt gttcttggat
      961 acactgataa gatgaatgat attttagctt ctatagatgt attagtaagc aaacctggtg
     1021 gacttactac aactgaggct cttttaaaag atgtacctat gatagttcct tattatatac
     1081 caggtcagga agaagagaat cttgatttct tatctaattg tggtgcagca cttagaacta
     1141 caaaaaaata taacttgtca atattactaa aagttttaat agatgaccct agcagattag
     1201 aaatgctaaa aagaaatatt aaatcaataa gaaagtcaaa ttcagcccaa aatatagcta
     1261 atttaatttt aaatataatt tctggttgat aaaataaata aaatccctat agtatatata
     1321 ttatctatta gggatttttt attttctaat tatttaatat taaattggtt cataaaagtc
     1381 ttcttcataa tcatactgat aatttttata attatttcta aattcagcat ttttatttcg
     1441 tacatttttt ttagtttttt tcttattaga aaaacttata tcctcaaaat catcatattt
     1501 aggtttatct tttgatttca tttttttaac tcttttttct ttcattgcat tatgttcttc
     1561 taagttcata attggtttca tgttgcaccc ctatcaaaat ttttaaatga tttatacaac
     1621 aaattataca atacagaaga aatttattca ataaatctaa atcaaaatta atttgaattt
     1681 aactcaaaaa attacaaaaa tcgaggtatt aacctcgatt tttatatttc tcttctgcct
     1741 tctagtgctt ttgatattgt gacctcatct gcatactcta aatcgcctcc aacaggaaga
     1801 ccatgagcta tccgagtgac tttgattccc attggtttta ctaacctagc aatatacatg
     1861 gctgtagctt caccttcaat agtaggattt gttgccatta ttatttcttt gacttcctga
     1921 ttgccaagtc tttggataag ttcctttatt tttaacatat ctggtccaat tccatccatt
     1981 ggagaaatta ctccatttaa tacatggtac tgtcctttaa actctctcgt tctctccata
     2041 gctgctacat ctcttggatc ttccacaaca catataacac ttgaatctct acttttattt
     2101 gaacacatgc tacatgggtc tgtatctgtt atattacaac aaattgagca atatcttatt
     2161 tctctttttg catctataat cgctttagat aaagcttcca catcattagt attcatatta
     2221 ataatatgaa aagccaatct ttgagcagtc tttcttccta ctccaggaag ctttgaaaat
     2281 tcctctataa gtctcgttat gggacctgta taaacttgca taaataccac ctactagaat
     2341 aacccaggta tattcatacc tccagttacc ttactcattt gacttgcttg tatatcatca
     2401 atatttctca atgcttgatt tactgcactt aaaactaaat cttgtagcat ttctatatca
     2461 tctggatcaa ctacttctgg cttgatagtt atatctataa cttctttttt accattaact
     2521 tttacagtaa ctgctcctcc accaactgaa gcttctactt ctttactttc taactcttgt
     2581 tgagcttttt gcatattttc ttgcattttt tgagcctgct ttaacaagtt gttcatattt
     2641 ccaccaccag gcatcattcc gcctccaaaa ccttttttag ccataaacac tattcctcct
     2701 aaacttattt tcattttatt attatatcat aatagtattt tattatttac tctcattttc
     2761 atcaatacta tcttttattt ctaatatctc ttcactcact atgttcttta atatttcctc
     2821 accaatgtcc tttttctctt taacttcaag atttatatct ttaacttctg atgtcagtac
     2881 tatttttaca ttaaaacttc tatttaaaac atctcttatt gttttttcta aataatttat
     2941 tgtatcttga gagctcagtc tagtttttgc aaaatcaaat ttatcatcaa atataacata
     3001 caacatatta gaatatacat taaaactttt tacttcactt aagagtgcgt atattggcat
     3061 ttttttatct tttttaattt gtttaagtat attcttccaa gatgactcta taagtataac
     3121 gtcctcattt tttacatctt cataaactac attttcttgt tttacatcta tttctctatc
     3181 gacctcatac tctttttctt tattattccc aattttttca gacttaaagt tccccagttc
     3241 aatcattttt tctaagttct caactctttt tataagagct tctttacttt catcaaacat
     3301 tggttgagca attttcatta tggttatttc cactaaaacc cttggatttg aagatgactt
     3361 tatatcatcc tgagttattg ataatatatt taaaatcctt attaaatcat ttatatctat
     3421 atttttagac tgaattttaa gttgttctat agtttcttct ggtaatgaaa ttatttcatc
     3481 caattctgat gaaaccttac ataccattaa atttctaaaa tgatcaatta agtcatttat
     3541 aagatttctt atatctttgc cccataagac aaattcattt aatatctcaa gagacttttt
     3601 agtgtcctgc tctactatac attgagacaa ttcaaataat tgttctatat ttacgcttcc
     3661 cattaattca acaacatctt tataatctat cttactttct ccaaaagaca tacattggtc
     3721 taatatacta agtgcatctc taagagctcc ttgagaattt ctagctatta aattaagagc
     3781 tttatcatct atatcaattc cttcatcttc acaaatcttt ttcattctaa gggtcatatc
     3841 tttaactgta actcttttaa aatcgtatct ttggcatctt gataaaatgg ttgcaggtat
     3901 tttgtgaggc tctgtagttg ctaatataaa aattacatat gatggaggtt cctctaaggt
     3961 ctttaataat gcattaaaag ctccttgaga caacatatga acttcatcta ttatatatac
     4021 tttatattta gcattggctg gagaatattt cacactttct ctaagctctc ttatatcatc
     4081 tacactatta tttgaagctg catctatttc tacaacatcc attgtattat cttttaatac
     4141 agattcgcat atctcacact cattacacgg ttcttcattt attttattca aacagtttac
     4201 tgctcttgaa aaaatctttg cagtagatgt tttaccagta cctcttgttc cacaaaacaa
     4261 ataagcatgt cctatattat cactatatat ttgattcttt aaagtcttaa taatatgatc
     4321 ttgaccaata acatcttcaa atttttgtgg tctatatgct ctatataatg ctttatgcat
     4381 ctttttacct ctctttagca aaattaataa aaaaatccct cattatctaa gggattagtc
     4441 ttttatatat taaatgctgt acaccatcta tcgacttaat tccataggcg ttaccaaaac
     4501 agttagctca acttaggcac ccccacggca cacaaaagtg atcacttacc gctgcttcct
     4561 tccggatctg acggggttca tgagctttca ttgcgcagga cctaagcatc aacaccactt
     4621 atttagggcg gccctacaga aaataagcct ttagatggaa ttcaatcctg ctatagcgga
     4681 ttgcaggtta cagggcaccg ctacctcccc atctagtaca gcaaaattac aaccatattt
     4741 aattactttc attgtttctg gcggagagag tgggatttga acccacgata cagttttacc
     4801 catatactcg ctttccaggc gagcgccttc gaccactcga ccatctctcc ttaatctctt
     4861 tttctcaatg ccttaaaaaa ttcttgcaat atgatcgagc attcttcttg caaaacatca
     4921 aaagctactt ttacattatt attattaaaa taatctaatt taaactcatg ctgtttttct
     4981 atatatgaat tttttacatg tcttgtccct attataagct tttttattct agaattaact
     5041 attgcgccac tacacattat gcaaggttcc attgtaacat ataaatcaca atcagtcaac
     5101 ctccaaccac ctaatttttc tgatgcttgt tttatcgcta aaatttctgc atgtgccgta
     5161 gagtctttta acgtttctgt aaggttatga gctctagcta ttatttgatt atctttaact
     5221 ataatagcac ctattggtgt ttctttttta ttatatgctt tatatgcttc ttttaatgct
     5281 tctttcatat aaaatgaact ttccataatt cctcccaaaa cttataacaa acttatctta
     5341 tcataattca ttttataatt caacttaatt ttattttgtt tatttaatta ttactatata
     5401 tagctatatt tttttaaaat tagttctaaa ataattttta gatattcata caagagtgtt
     5461 ttataaaaat atttagtgtt ttatgatgaa aattctgctg tgtaaattaa cataaaaaaa
     5521 ctatgaaatt aatatttata ataatttcat agttttttta tttattgttt actcataata
     5581 tattctcttc atcaaagcat actctatata tacaattaat ataaatttat tttataacat
     5641 caacacccat ataaggtctt aattcttctg gaactactac agaaccatct gcctgctgat
     5701 aattttctaa tatagcagcc aaacatcttc ctattgctaa tccagaacca tttaatgtat
     5761 gaacatattc tgcttttgat tttttatctc ttttaaatct tattcctgct cttcttgctt
     5821 ggaaatcttc aaaatttgaa caagaagata tttctacata tctattgtaa cttggcatcc
     5881 aaacttctaa atcatattta aatgcagctg taaatcccaa atctcctgta catattttta
     5941 caactctata tggaagacct aacatttgta acatagtttc agcatcatga gttaatgatt
     6001 ctaattcatt ataagaatct tctggtttaa caaatttaac taattcaact ttattaaatt
     6061 gatgttgtct aactaaacct cttgtatctc ttcctgctga acctgcttca gatctaaaac
     6121 aaggagtata tgcacagtat ttaattggaa gctctgcaac atctaatatt tcattagcat
     6181 gtatattagt aacaggaact tcagctgttg gtattaagaa atactctaat ccttctattt
     6241 taaacatatc ttcttcaaat ttaggaagtt gaccagtccc tataaaacta tttctattgg
     6301 ccataaatgg aggtaagact tccgtatagc catgcttagc tgtatgagta tttaaaaaga
     6361 aattcattaa agatctttct aatctagctc ctaatcccct atataaagta aaccttgacc
     6421 cagttatttt ccctgctctt tcaaaatcta aaatacctag acctgtacct atatcccaat
     6481 gcgctttatg ctcaaaatca aatttagtag gttctcccca agttcttatt tgaacattgt
     6541 cttcatctgt ttcaccttgt ggtacctctg gatgaggaac atttggtatt ctcattaatg
     6601 tatattccat ttttgcttct acttctttta ctttctcatc aatacctttt atcttatctg
     6661 ataactcttt caatcttgcc ttttcttctg ttacatcttt tccttctttt attaattgag
     6721 gtattttttt agaatttaca tttaactcat ttttcataac ttcaacttct tgaagtattt
     6781 ctcttctttt attatctaat tccactacag catcaaggtc aaattctctt tcacctcttc
     6841 tttccatagc ttttttgata tcatctagat tttctcttat tcttttaata tctaacatat
     6901 taattcctcc taataatttt gataatataa gttataattc caacttaatt tacaaacatt
     6961 atacttgtaa actcttagtt taaacaaatt ttaaaaataa aaaaagacct ccgtttaccc
     7021 tataaaaggg acgaaaatct tttatccgcg ttgccaccct aattgactat actaaaatgt
     7081 ataatcctct cagacctata acgtaggtaa acgtctagct ttaactagaa gctctagagt
     7141 agattcaaaa accattgtaa tgagttttca ccatccactc attctctgaa tacaatctgt
     7201 tttttactat tttccttcac agctttttaa ctaattgttt tatttgataa tcattatatt
     7261 atatatatta acatctttca atactattat tcaaattttt ttagaatttt ctttaatttt
     7321 ttatattaaa ttcatttttt ctatttaatt aaaaccttat cttttatcca ttgtatttag
     7381 attacctgta ttattaaata ataatgaaga aggaacaaat ggaactttta tatcattctc
     7441 atcaaattta ttttttacct tttccattac atcaaaatat acatcccagt aatcatcagt
     7501 ttttacccaa ggtctagcaa ctatttgcat ggtgttattt cctatagagt ttaaacctat
     7561 tataggcttt ggatcattta atattctttt ttcgtttgta aaaatttcat ttaatataga
     7621 cttaactaca tctatatcac tatcatatga aatattatat gaaaaatcta ttcttctttt
     7681 gttttgatgt gtgtaattaa ttatattatt acttgtcagt tgaaaattag gtataattat
     7741 agttttatta tctggcgtct taagaacagt gctaaatatt tgtatgtcag aaactgtacc
     7801 ttctacacct gaaccttgaa tataatcacc tatattaaat ggcttaaaaa ataaaataat
     7861 cataccagag cctaaatttg ataatatttc tttaaaagct aaacctatac taaatccagc
     7921 agctcctaac acagctacaa ctgatgtagt ttgtatccct ataataccta agcttatcaa
     7981 tgatataata gataacatag atatatatat tccatataca ataaaattat ttacaccttt
     8041 actcattcca tatttgatta gaaactttga aaccatcctt cttactattt tagatatata
     8101 aatacctatc acaaatacaa ttattgcata tataatattt ggtatattat cactaaaatt
     8161 atcgagcata ttttctaaag ttctcttagt tatattgcta tttgttgagg cagtcttagc
     8221 caatgataaa aaattcattc aactcctcct tatgataata ttccgttgtc ctttaactct
     8281 tttactatag cttctatagt ttcttctttt attgcctcaa ttgtatgaat atggctacat
     8341 tctgtcagaa ccgataattg tttaaattca tttgtctcaa ctttcttcat aaagttgtct
     8401 atatccattt tagaataaat attaagttct gcagttatct gaccatatgt tggatgattt
     8461 acgatgacat cttttataat accacctaaa tccacaatta tctttaattc atcataaatt
     8521 tctttagaat ccttatgatt tttacacttt atttgttttg taaaatacgg ttgattatat
     8581 attatatatc cttgaggtgt agctattatt tcaaatcctc tagctcttat aagggctata
     8641 tcttgaacta ttacttgcct acttacattt aatagttcag ctagtgttcc accttttaca
     8701 ggatgcttag attcttttaa aatatctatt aatttacttc ttctttcatt agaattcata
     8761 ttacaccttc tttccaaata aaaactttac ctatactata taattttata ttttatctta
     8821 ttataaatca atattgactt tatattctat ttaatcttaa cttttataat aaataaaaaa
     8881 ga
//
LOCUS       DAEQCW010000131         8810 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.132, whole genome shotgun sequence.
ACCESSION   DAEQCW010000131 DAEQCW010000000
VERSION     DAEQCW010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8810)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8810)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8810
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.132"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            199..966
                     /locus_tag="KRO40_003167"
     CDS             199..966
                     /locus_tag="KRO40_003167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBH2093965.1"
                     /translation="MGEIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRT
                     LVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIVKPYTKKLNQEFNEVVN
                     VSILEERAQDSPRSIIIHKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFE
                     KYRKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKA
                     IAAISLSGPTIRMREGDFEYKIKRVIETAKSISELFR"
     gene            1249..1446
                     /locus_tag="KRO40_003168"
     CDS             1249..1446
                     /locus_tag="KRO40_003168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2093966.1"
                     /translation="MEKVKLSVERCKGCYLCIEACKKDAISLSDYTNKKGFVTIKVDE
                     EKCIQCGACYTMCPDLVFEIL"
     gene            1475..2551
                     /gene="vorB"
                     /locus_tag="KRO40_003169"
     CDS             1475..2551
                     /gene="vorB"
                     /locus_tag="KRO40_003169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBH2093967.1"
                     /translation="MQSLLIKGNEALAEGAIRGGCRFYAGYPITPQSEILEMMAWRQK
                     EVGGVFIQGESEIASVNMVMGASALGARAMTSSSGPGFSLKQEGIAYWVSAGLPAVVA
                     CVQRYGIGDGFIGAGQDNYWQAVKGGGNGDYHLIVLAPNSVQENMDMAYESFELAEKY
                     MHPVLILSDATIGQMVEPCIAPPMKEYDMDKAPWAAKGTPVGEKNKVITDITYFEDQD
                     TWQKGYIEKMRKVQEDEQRWEEIEIEDAEVVFVAYGISSRIAEGAVRDARAKGMKLGL
                     IRPKTLWPYPRKAFKKLSDSLKGLVTVEMNMMAQMKEDVIIACDNRFPVYSVATAQYM
                     AEVNQLIDFAQQIIDGKAKQEEVF"
     gene            2554..3273
                     /locus_tag="KRO40_003170"
     CDS             2554..3273
                     /locus_tag="KRO40_003170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBH2093968.1"
                     /translation="MAKKAPAIMMCENMFCGGCGHSIVDRIIGEVLTEMDICQDTIIC
                     SDIGCNHMFQFSMNVDVVVPPHGKMGAAMAAMKRVRPDKYIFTIAGDGGAYAIGLGET
                     MSAATRNDNVIFLVMNNNMFAMTGGQMAPTTIEGQYTASTPAGRNYADHGSTFDVVKV
                     MGNLDIAYLARGTITNPKEINTTKRYIKKALEKQKEKKGFCLIEVLVPCPTNWGLKPV
                     DAMKRIENELVPKYPLGEFID"
     gene            3286..3825
                     /locus_tag="KRO40_003171"
     CDS             3286..3825
                     /locus_tag="KRO40_003171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBH2093969.1"
                     /translation="MLNEIICAGFGGQGVLTAGKIIMYVAYKAEKKITWFPSYGNEMR
                     GGSANCNVVVSDEKIANPCVKNPDILLGMNSVSVDKYESLMKKNGYMFVNESLVSKDR
                     KYREDINVIKVPVTEIAQNLGNEKAANICMLGAMVKSLDLFTKEEFESGMCEYFENQG
                     KGKFNSKNVEAFEAGYDYE"
     gene            3982..5040
                     /gene="buk"
                     /locus_tag="KRO40_003172"
     CDS             3982..5040
                     /gene="buk"
                     /locus_tag="KRO40_003172"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBH2093970.1"
                     /translation="MKVLVINPGGTSTKISVFQDENEILKKNITHTREDLKNFSKVFD
                     EYDYRKQLIVDILSSENHSINSFDAVVGRGGLMKAIKGGTYTVSEEMIEDMRNEINGE
                     HASNLGALLAKTIADEIGVQSFVVDPVSVDEFDDVSRITGISDIEKASWLHALNHKAV
                     SRKIAQKLGGKYEDYNFIVAHLGSGISIVAHKQGKMIDGSGGRSDGPFSPERSGGLLA
                     YPLIELCYSGKYTHDEMVAKVSSIGGMYDYLGTKDMIEIENRIKDGDEKAKLIMDAFI
                     YQVAKEISMYGASLSGNVDRVILTGGISHSEMVVKGVAEKVSYLAPIEIVPGEMEMEA
                     LALGALRVLNGEEIAKTY"
     gene            5058..5951
                     /locus_tag="KRO40_003173"
     CDS             5058..5951
                     /locus_tag="KRO40_003173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBH2093971.1"
                     /translation="MLKDFNNLLEEAKKLEPVIVSVAVAEDKEVLKAVKSATDLNIIK
                     PILVGDKDKIESISREIGLKGHEIIGCQNPDESVKKAVEIVKNKEAKVLMKGLVNTSV
                     YMRAILNKETGLRTGRLLSLLAVYELPQYHKLLYCTDSGINVSPNLNQKKDIMTNALL
                     TMKSIGMENPKTAILTANEMVDPKIQSTVDANLLVEMEKSGEIPKCIVEGPIAFDVAF
                     DAHAAEHKGIKSNIAGDVDLLVFPNIEAGNILGKSWLRFNKAKWAGIVLGATNPIILG
                     SRSDTAEIKINSIALACLASQ"
     gene            5981..7189
                     /locus_tag="KRO40_003174"
     CDS             5981..7189
                     /locus_tag="KRO40_003174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2093972.1"
                     /translation="MKYAKRMDMVKASAIRDSQKKIAQKVASGGTVISFAAGLPDPNL
                     FPIEEISEITQKVLNERGKFALAYGPTKGEDELLDLLVKRMKEEENIDTKAENIIITT
                     GSQQGIALSAMILLEKGDVVVTENPSYLGAINAFRPYECDFLGVDTDEEGMVTDDLDK
                     LLSENSNIKVIYVIPTFQNPTGKTWSLQRRKDFMEVVNKYDVIVIEDNPYGEIRFTPE
                     PLPTLKSLDTKDKVLYLGSFSKVLCPGFRVAWMCGNVDIIDKAELLKQGIDLQSNQFS
                     QVQVIEFLKKYNLNEHIEKIRAEYKKRCLLMLDAMKKHFPEEAKYTEPDGGMFIWVEL
                     PESINVDDLLDKAIDAGVAYVSGESFFANNGPKNTMRLNYTTMSEEQIVKGVEILAEV
                     IKKELNYACE"
     gene            7213..8472
                     /locus_tag="KRO40_003175"
     CDS             7213..8472
                     /locus_tag="KRO40_003175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2093973.1"
                     /translation="MGEKENGIKFGKLMFQLVIIAISWELVYIIPFIQYTLYDPILKA
                     LECTNTQLGFLLTIYGLGNIFGAPIGGWLADRFDYRKIILGSVFLNGVVSFLFAFNMN
                     YPFAVATWVGCAITSLVMNYPSMVKILRVIGKDNQGKVYGFNEAMVGVSGVVMGAIFL
                     YIYTCFATPTLGMRWVMISLGILSIAMCPVLWFVIKDVDIKEEREEAGEKMSAGDFIT
                     VLKSPNTWLVGISIFCVYSFTVTMSYFTPYITSVLGGSVALSGALAIIRQHGLKLFGA
                     PFGGYCADKLKSPTKVLLPIYVFGIAVIVLFLVLPASTPMTIFIALTFVVGILGYMGK
                     GIYYAVQDEVKVPVKYSATTIGIAAALGFSPDVFQFALIGHWIDTYGNKGYTYTFIFQ
                     IAILVIGILSCLYILKVKKRRASKLEA"
BASE COUNT         3428 a          974 c         1743 g         2665 t
ORIGIN      
        1 aatataacag aataattcta ttaaaagtaa gaataataag gacatagtga gtattttgtt
       61 tttattttac aaattaagta taatattttt gttttataaa atataattaa gataaataga
      121 taattttgta attttaatat ataatattta gtagagtgtg ggagtagcac ttaatatttg
      181 caggaggagt ttttgtatat gggagaaata ataaatgcat tagatagagc cctagacata
      241 attttgctgt tatatcatga aaagagagaa atgggaataa ctgaaataag taaggctatg
      301 ggagtatata aaagtactgt acatagaact ttggttactc ttgaaaacaa aggttttgtt
      361 atacaaaatg cagagaatgg taagtattgg ctaggaataa atttatatgc aataggtatg
      421 gttgtgggag aaaaaatgtc attgactgaa atagtaaaac catatacgaa aaaattaaat
      481 caagaattta acgaagtagt taatgtatct atattagaag aaagagctca agattctcca
      541 agaagtatca taatacataa agagtatggt tcaaatcaat tactttcagt aaatccatcc
      601 gttggttcaa gtagtgaatg ttattgttca gcagttggta aatgtcttat ggcatttaat
      661 gattctatag attttgaaaa atatagaaaa acaccaatac acaagtatac agaacataca
      721 attgataatt gggatgatat gatgcttttt ttagcaaaaa taaaagaaca aggatatgct
      781 atagatgatg aagaactaga acatggacta acttgtattg gagcacctat cttagataaa
      841 aataataaag ctattgcagc cataagtttg tcaggtccaa ctataagaat gagagaaggg
      901 gactttgagt ataagattaa aagagttata gaaactgcaa aaagtatatc tgaacttttt
      961 agatgatttt taatctcgat aataaaaata ggctatattt aaattgttat ttgtaaatat
     1021 cagtttaaat gtagcctatt tttctttaat ctaaaattaa atattcttaa aatttaaaat
     1081 gttattgaaa tatataagcg aatgtgttat cttttaatta agcaataaaa atagaacaag
     1141 gttctatact atagaacaaa attgatgcat atatagtatt tatacaaaat ataaatatta
     1201 tatatttaaa attaagtaaa aatattacat aaaggggaga tttgagaaat ggaaaaagtc
     1261 aagttgagtg ttgaaagatg taagggatgc tatctttgta ttgaagcttg taaaaaagat
     1321 gcaataagtc tttctgacta cacaaataaa aaaggctttg taactattaa agtcgacgaa
     1381 gaaaaatgta ttcaatgtgg cgcttgttat acaatgtgcc ctgatttagt atttgagata
     1441 ttataaatta tttttattag aggggagaaa aggtatgcaa agtttattaa ttaaaggaaa
     1501 tgaagcttta gcagaaggtg ctatacgtgg tggctgcaga ttttatgcag gttatccaat
     1561 aacaccacaa tcagaaatat tagaaatgat ggcatggaga caaaaagaag ttggaggagt
     1621 atttatccaa ggtgaatcag aaatagccag tgtaaatatg gttatgggag caagtgcact
     1681 tggagcaaga gctatgactt cttcatctgg tccaggattt tcattaaaac aagaaggtat
     1741 tgcatattgg gtatcagctg gtttgccagc agttgtagca tgtgtgcaaa gatatggtat
     1801 aggtgatgga tttataggag ctggtcaaga taattattgg caagcagtaa aaggcggtgg
     1861 aaatggagat tatcatttaa tcgtgttagc acctaatagt gttcaagaaa atatggatat
     1921 ggcatatgaa tcttttgaat tggctgaaaa atatatgcat ccagtactta tactttctga
     1981 tgctacaata ggtcaaatgg tagaaccttg tatagcacca ccaatgaaag aatacgatat
     2041 ggataaagct ccatgggctg caaaaggaac acctgtagga gaaaaaaata aagtaataac
     2101 tgatataaca tattttgaag accaagatac atggcaaaaa gggtatatag aaaaaatgag
     2161 aaaagttcaa gaagatgaac aaagatggga agagatagaa atagaagatg ctgaagtggt
     2221 atttgtggca tacggtattt catcaagaat agcagaaggt gcagttagag atgctagagc
     2281 aaaaggaatg aaattaggtc taataagacc aaaaacattg tggccttacc caagaaaagc
     2341 atttaagaaa ttaagtgatt cattgaaggg acttgtaaca gttgaaatga acatgatggc
     2401 acagatgaag gaagatgtaa ttatagcatg tgataataga tttccagtat attcagtagc
     2461 aacagctcaa tatatggcag aagtaaatca attaatagat tttgctcaac agattataga
     2521 tggaaaagct aagcaagagg aggtatttta attatggcta aaaaagcacc agcaataatg
     2581 atgtgtgaaa atatgttctg tggaggctgt ggacactcta tagtcgatag aattattgga
     2641 gaagtattaa cagaaatgga tatatgtcaa gatacaatta tatgttcaga tataggttgt
     2701 aatcatatgt ttcaatttag tatgaatgta gatgttgtcg ttccacctca tggtaaaatg
     2761 ggagcagcaa tggcagctat gaaaagagtt agaccagata aatatatatt tacaatagct
     2821 ggagatggtg gagcttatgc aatagggctt ggagaaacta tgtcagctgc tactagaaat
     2881 gataatgtaa tatttcttgt tatgaacaat aatatgtttg caatgacagg agggcaaatg
     2941 gctccaacta ctatagaagg tcaatataca gcttctactc cagcgggtag aaattacgca
     3001 gatcatggtt caacatttga tgttgtaaaa gttatgggaa atttagatat agcatatcta
     3061 gcaagaggaa caataactaa ccctaaagaa ataaatacaa caaaaagata catcaaaaaa
     3121 gctctagaaa aacaaaaaga aaagaaaggt ttttgcttaa tagaagtgct tgtaccatgt
     3181 ccaacaaact ggggattaaa gccagtagat gctatgaaga gaattgaaaa tgaacttgtt
     3241 ccaaagtatc cacttggaga atttattgat tagggaggaa ataatatgtt gaatgaaatt
     3301 atatgtgctg gttttggagg acagggagtt cttacagcag gaaaaattat aatgtatgtt
     3361 gcatataagg cagaaaagaa aattacatgg ttcccatctt atggaaatga gatgagggga
     3421 ggaagtgcaa attgcaatgt tgttgtaagt gatgaaaaaa ttgcaaatcc ttgtgtaaaa
     3481 aatccagata tactattggg aatgaacagc gtatcagtag ataagtatga aagtttaatg
     3541 aaaaaaaatg gttatatgtt tgtcaatgaa tcactagtaa gtaaggatag aaagtacaga
     3601 gaagacatta atgttataaa agtacctgtt actgaaatag cacaaaattt aggcaatgaa
     3661 aaagctgcta acatttgcat gttaggtgct atggtaaaga gtttggattt atttacaaaa
     3721 gaagaatttg aaagtggtat gtgtgaatac tttgaaaatc aaggcaaagg taaattcaat
     3781 tctaaaaatg tagaagcatt tgaagctgga tacgactacg aatgaatatt ttaaatattt
     3841 aaaataatta ttgaaatact tatttttata tgttagtatt taattaataa aatatagaac
     3901 gtcgttctgg acaatgggac aaagtcttta ggtcggaata caagaacgac gttctgcata
     3961 gtagaactag ggggtgttaa attgaaagtt ttagtaataa atcctggtgg tacatccaca
     4021 aaaatttctg ttttccaaga tgaaaatgaa attttgaaaa aaaatataac ccatacaaga
     4081 gaagatttaa aaaatttttc taaagtattt gatgaatatg attatagaaa acaactgata
     4141 gtagatattt taagtagtga gaatcatagt ataaattctt ttgacgcagt agttggtcgt
     4201 ggtggactta tgaaggctat aaaaggtggt acctatactg tgagtgaaga aatgattgag
     4261 gatatgagaa atgaaataaa tggggaacat gcatcaaatt taggtgcatt attagctaaa
     4321 actatagctg atgaaatagg agtacaatca tttgtagtag acccagtttc tgtagatgaa
     4381 tttgatgatg tatcgaggat tacaggaata tcagacatag aaaaagcaag ttggttacat
     4441 gcattaaacc ataaagctgt ttcaagaaaa attgcacaaa aactaggggg aaaatacgag
     4501 gattataact ttattgtagc tcatttaggt tcaggaatat cgattgtagc acataaacaa
     4561 ggcaaaatga ttgatggaag tggtggtagg tctgatggtc cattttctcc agaaaggagt
     4621 ggtggattac ttgcatatcc tcttatagaa ttgtgttact ccggaaaata tactcatgat
     4681 gaaatggtcg caaaagtaag ttcgattggg ggaatgtacg attatttagg aacaaaggac
     4741 atgatagaaa ttgaaaacag aatcaaggat ggtgatgaaa aggcaaaact tataatggat
     4801 gcatttattt atcaagtagc aaaagaaatt tctatgtatg gagcttcact ttcagggaat
     4861 gtagatagag ttatcttgac aggagggata tctcactcag aaatggtagt caaaggagta
     4921 gcagaaaaag tttcatatct agctccaata gagatagtac caggagagat ggaaatggag
     4981 gcacttgctc taggggcact tagagtactt aatggagaag aaatagcaaa aacttattaa
     5041 tatttaggag aaagagtatg ttaaaagatt ttaataattt attagaagag gctaaaaagc
     5101 ttgaacctgt tattgtaagt gttgctgttg cagaagacaa agaagtatta aaggctgtga
     5161 aatcagcaac agatttaaac attataaagc caattcttgt aggagacaag gataaaatag
     5221 aaagtatatc aagagaaatt ggattaaaag gtcatgaaat aataggttgt caaaatcccg
     5281 atgaatcagt taaaaaagct gtagagatag ttaaaaataa ggaagctaaa gttcttatga
     5341 agggattagt aaatacaagt gtctatatga gagctatatt aaataaagaa acgggtctta
     5401 gaacaggaag attattaagt ttgcttgcag tatatgaatt acctcaatat cataaacttc
     5461 tttattgtac tgatagtgga ataaatgtat cgccaaactt aaatcaaaaa aaagatataa
     5521 tgacaaatgc acttcttact atgaaaagta taggcatgga aaatcctaaa actgcgatac
     5581 ttactgcaaa tgaaatggta gaccctaaga tacaatctac agtggatgcc aacctacttg
     5641 tagagatgga aaaatcggga gaaataccaa agtgtatagt ggaaggtcca atagcatttg
     5701 atgtagcatt tgatgcacat gcagcagaac ataaaggtat taaaagtaat attgctggtg
     5761 atgttgattt attagtattt ccaaatatag aagcagggaa tatattagga aagtcatggc
     5821 ttagatttaa taaagctaag tgggcaggta tagttttagg agcaacaaat ccgataattt
     5881 taggttcacg ttctgacaca gctgaaataa aaataaattc aatagcatta gcgtgcctag
     5941 catcacaata agaaattatt attaaggagg aaaaagtatt atgaaatatg caaaaagaat
     6001 ggatatggta aaagcttcag ctataagaga ttctcaaaag aaaatagctc agaaggtagc
     6061 aagtggtgga actgttatat cttttgctgc agggcttcct gacccaaatt tatttccaat
     6121 agaagagata agtgaaataa ctcaaaaagt acttaatgaa aggggaaaat ttgccctagc
     6181 atatggacct actaaaggtg aagatgagtt gttagatcta ttagtaaaaa gaatgaaaga
     6241 agaagaaaat attgatacaa aagcagaaaa tattataata actactgggt cacaacaagg
     6301 gatagcatta agtgctatga ttttattaga aaagggagat gtagtagtta cagaaaatcc
     6361 aagttactta ggtgcaataa atgcatttag accttatgaa tgtgattttt taggagtaga
     6421 tacagatgaa gaaggaatgg taacagatga tttagacaaa ttattatctg aaaattctaa
     6481 cataaaggtg atatatgtaa taccaacatt tcaaaaccct acaggaaaaa catggtcttt
     6541 acaaagaaga aaagatttta tggaagtcgt gaacaaatat gatgtcatag taatagagga
     6601 taatccttat ggagaaataa gatttacacc agaacctcta cctacactta aatctcttga
     6661 tactaaagat aaagtattgt accttgggtc attttcaaag gtattatgtc caggatttag
     6721 agttgcttgg atgtgtggta atgtagacat catagataag gcagaacttt taaaacaagg
     6781 tatagattta cagtcaaatc aattttcgca agtacaagta atagaatttt taaagaaata
     6841 caacttaaat gaacatatag aaaaaataag agcagagtat aagaaaagat gtctgctaat
     6901 gttagatgct atgaagaaac atttcccaga ggaagctaaa tatacagaac cagatggagg
     6961 aatgtttata tgggttgaac ttcctgaaag tataaatgta gatgatttat tagataaagc
     7021 cattgatgct ggagttgctt atgtttctgg agagtccttc tttgcaaata atggtccaaa
     7081 aaatactatg agacttaact atacaacaat gtcagaagaa caaatcgtta aaggtgttga
     7141 gatacttgca gaagttataa aaaaagaact caattatgct tgtgaataaa tataaaaagt
     7201 gagggtttaa atatgggaga aaaagaaaac ggtataaagt ttggaaagtt aatgtttcaa
     7261 cttgttatta tagcaatatc ttgggaatta gtttatatta taccatttat ccaatataca
     7321 ttatatgatc caatcctaaa agcattagaa tgtacaaaca ctcaactagg ttttctactt
     7381 acaatttatg ggttaggtaa tatatttgga gctcctatag gaggctggtt agcagataga
     7441 tttgattata gaaagataat tttaggttct gtatttctta atggagtagt atcattttta
     7501 tttgcattta atatgaacta tccatttgca gttgctactt gggtaggttg tgcaatcaca
     7561 tcattagtta tgaactatcc ttctatggta aaaatactta gagttatagg aaaagataat
     7621 caaggtaagg tttatggatt taatgaagct atggttggag tttctggagt agtaatggga
     7681 gcaatattct tatatattta tacatgcttt gcaactccta cattgggtat gagatgggta
     7741 atgatatctt taggaatatt atcaatagca atgtgtccag tattatggtt tgtaattaaa
     7801 gatgtagata ttaaagaaga aagagaagaa gcaggtgaaa aaatgtctgc tggtgatttt
     7861 ataacagtac taaaatcacc aaatacttgg ctagtaggaa taagtatatt ctgtgtatat
     7921 tcattcacag ttacaatgtc ttattttaca ccatatataa catctgtact tggaggttct
     7981 gtagcattat ctggtgcatt agcaataata agacagcatg gtctaaaatt atttggagca
     8041 ccatttggag gatattgtgc agacaaatta aaatctccta caaaagtact tttaccaata
     8101 tatgtatttg gtatagcagt aatagtttta ttcctagtat tacctgcatc aactccaatg
     8161 actatattca tagctttaac atttgtagta ggtatattag gttacatggg aaaaggtata
     8221 tattatgcag tacaagatga agtaaaagtt ccagttaaat attcagcaac tactataggt
     8281 atagctgcag ctttaggatt ttcaccagat gtattccaat ttgcattaat aggacactgg
     8341 atagatactt atggcaataa aggttacaca tatacattta tattccaaat agcaattcta
     8401 gttattggaa tactatcttg tttatatata ttaaaggtta aaaagagaag agcaagtaaa
     8461 ttagaagctt aaatattcaa tttggtaatt aagtatatat aaatacaata cttattttga
     8521 tgaatgtgat tgtataaata acataaaaaa tatcaataga ttaagtttta taataatgtt
     8581 tagagaataa agtataaaaa tcaaaatgtt atcaagtttt ctaggtttta acataaagtt
     8641 acccctgaag gtgtaaaatt gagtggcaat tattatctat tttcttacct acataaacct
     8701 atttaattta aattctaaga gattttcaaa atagatggta gttgtactca attttaaacc
     8761 tcataataaa tacgaaaatt taaaatctaa ctagatacta tttaattata
//
LOCUS       DAEQCW010000132         8711 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.133, whole genome shotgun sequence.
ACCESSION   DAEQCW010000132 DAEQCW010000000
VERSION     DAEQCW010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8711)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8711)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8711
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.133"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(67..1839)
                     /locus_tag="KRO40_003176"
     CDS             complement(67..1839)
                     /locus_tag="KRO40_003176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitric oxide reductase activation-like protein"
                     /protein_id="HBH2093974.1"
                     /translation="MKWIYDDYEFENRANNLSWTIAGDYNESIDISEKDYSSKEIGLY
                     FAIIAGARRKYVDWDIVKKYLTNRIRKGYNKDIILGLIQVILNTIVEEKVIKDRPGIE
                     DIRRNAYKDIVSRFTKIHNDNIMDKIKYTFVLYSMDKHPALDSMTRRIVNDIRNIDTN
                     QDIMEILKALDVIYLTYFEYILNGEENSLIDENNVESVEVNFDTFADFMYEELYSDEE
                     ENIIESDIDSISSSMLVEGVGDFDDSKCSNSADRVIYVDEDTANKIYSKIEHYYGKTY
                     LSKGEIKKIETQNCRNVHEGCRIHFTDGVLRSECNNVFQLKYVTRQKENNLGKFREHA
                     RMYRQQIKRLKESLSRILIEENAKSRVYSDCGTILANRAWRVGRSNNNKIFYKDIENE
                     KGKYVIDILLDASGSQSRNQGNVAIQAYIIANALTEVGIPNRVMGFSSFLDYTILKRF
                     KDYDDSIKNSENIFEYFCAGNNRDGLAIKSICSGLINRDEENKILIVLSDGRPNDVKI
                     GKSSERTLRGEKAYRGIVGLRDTANEVRKARKQNILVLGVFTGKESELEAERLIYGND
                     FIYSRDITRFSDVVSMYLKKIIRN"
     gene            complement(1853..2782)
                     /locus_tag="KRO40_003177"
     CDS             complement(1853..2782)
                     /locus_tag="KRO40_003177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2093975.1"
                     /translation="MDIIDNLRVQGVDEKLIEDVLYFRNYYGLEKDLEYRVTKSKTYF
                     YGKDILSMCIAAILEEENILLSGPKATGKNLLADNLGEIFNRPQWNTSFHINTDSSTL
                     IGTDTFIDNEVKLRRGSVYECAINGGFGVFDEINMAKNDAIVVVHSALDYRRIIDVPG
                     YERVNLHPATRFIGTMNYEYAGTKELNEALVSRFMVIDIPPIEEDKLMMILKNEFSDA
                     DEEKLIHFAGIFLDLQLKSQNGEISSKAIDLRGLMASLKTIRRGLKPTLAINMGLTGK
                     TFDVYEKEMVGDVIKTRIPNKWESIDVFPISHI"
     gene            3010..3198
                     /locus_tag="KRO40_003178"
     CDS             3010..3198
                     /locus_tag="KRO40_003178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2093976.1"
                     /translation="MEYMSCPEVAKKWGISERRVQKLCEESRIPGVSKLGYMWLIPKN
                     AEKPVDGRTKRRKEVQYE"
     gene            3191..3892
                     /locus_tag="KRO40_003179"
     CDS             3191..3892
                     /locus_tag="KRO40_003179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093977.1"
                     /translation="MNSVLIIDDDKELCALMKKCVEQENLSAIIAHCGAEGLHLVDKN
                     RHTLSLVILDIMMPDIDGFQVLKKIRETSNIPVIMLTAKNDEDDKVSGLRLGADDYLT
                     KPFSINELMARVNSLIRRYTMLNPAFITDTDCIIINGMIIDKTNRIVSVNNIPVQLTS
                     KEFDLLAFLASNKGQVFTKKQIYTQVWEEEYAFDDSNIMSFISKLRKKIEPDPNHPFY
                     ILTVRGVGYRFNKEA"
     gene            3894..4817
                     /locus_tag="KRO40_003180"
     CDS             3894..4817
                     /locus_tag="KRO40_003180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2093978.1"
                     /translation="MNTSVYLLLILVLSLIIIAYLVSVLLRVRIQLTLIKDALEDIKN
                     GNLNRRILTDENDITKQICYDINEIAINSQFQLIQQKQSEQAYKQLMTSLSHDVKTPL
                     ASLVGYLEAVESKIVVGEEKDEYIHVASNKAHYLKNFVENLFEWVKLDSKEQVFHFDI
                     FDLNELSRNIISDWIPVLESSHFEYEFDIPEIEYFLRIDANAYTRIINNLLQNIITHS
                     SGNKMTLRIFENKEQAQIIITDNGKGISSDNLPHIFERLYQCDHSRASKGNGLGLAIA
                     KELINAHKGNITANSTPGMGTEFTILLPKAL"
     gene            4974..5897
                     /locus_tag="KRO40_003181"
     CDS             4974..5897
                     /locus_tag="KRO40_003181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019639192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2093979.1"
                     /translation="MNDFVIETKQLTKIYGNQTVVDKVNLHVKKGRIYGLLGRNGAGK
                     TTIMKMILGLTSITYGEVDVFGENIKEREKQVYPRIGAIIETPGFYPNLTGTENLEIF
                     AKLRGTAAPNSVKRALEIVGLPYKNKKLFSKYSLGMKQRLGIANAILHDPELLVLDEP
                     TNGLDPIGIAEMRKFIRDLSVEHGKTILISSHILSEISLLADDIGIIDHGVLLEESSM
                     SELEKKNSKYILLQVSDIPKTSLILERQFNTKDYSVQDDYTLHLYNTNLDMGEINKAL
                     VMQNVTVISSQLCNDTLEDYFKKITGGEGIA"
     gene            5890..6627
                     /locus_tag="KRO40_003182"
     CDS             5890..6627
                     /locus_tag="KRO40_003182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093980.1"
                     /translation="MLKLIQTEFLKLRRRKLIWLMLLSALIMPFFALLYFNYFGKTGV
                     EPIKFYKWSAFGYTLWIILPVVLGIFCTMLIHEENQYDMLKQLWIVPISKMGYFFSKF
                     FVVLIYSICFMLITAVASVLFSVLSGYVVFSWASILYLLKKCLEIGVITAFVMLPILA
                     IATSQKGYILPICITLVYAFSGFVIMTINMYLHPLSSMGVIIMRNKDIPGLIFSQEIN
                     VPLAFLCICIWSIVSVLFANIALGRRK"
     gene            6638..7411
                     /locus_tag="KRO40_003183"
     CDS             6638..7411
                     /locus_tag="KRO40_003183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2093981.1"
                     /translation="MWKLLWAECQKIRRSKIVWITVFASIMIAVIVFAGGQDVYNDPD
                     LHYGLKSVYDGSRYIDNAGWYMDAVQPWSTFFVLPAVIALLGSYIICREEEEDTIKSL
                     RLIPINETNLTIAKMIITFIFSILLYLLLFTITFLTESVLHFSDLSTKLVLSCMKEYF
                     LDGIGVFFAISPIIALVSRMKKGYWLALVFTEVYSIAGLFAGMSNVLQTFFPIAAIFN
                     ISGYYITTGEKIMGSIISLLLCACLSAFILKGLKHNEKN"
     gene            complement(7938..8546)
                     /locus_tag="KRO40_003184"
     CDS             complement(7938..8546)
                     /locus_tag="KRO40_003184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DedA family protein"
                     /protein_id="HBH2093982.1"
                     /translation="MSVINSFILQYGLISVFVLIMIEYACFPLPSEVVLPLCGAIAAR
                     NHFGFLTILILSIIAGILGSIFCYTVGNWGGKSIINKIIEICPKAKKGIFASQDYFNK
                     YSSISVCVCRLIPLCRTYISFIAGIAGQNIITFVISSIVGITIWNTSLISIGYIFSES
                     WVRIMSHYNDYKFLVLIIPISIIFIGFVIKSFIHKKHHKIRL"
BASE COUNT         2879 a         1434 c         1244 g         3154 t
ORIGIN      
        1 tacatttttt ataaatttta ttcattttta tatttttatg tatataaatt cttttttgta
       61 agtttattaa tttctaatta tcttctttaa atacattgaa actacatcag aaaatctagt
      121 tatatctctt gaatatataa aatcatttcc atatattaat ctttcagctt caagttctga
      181 ttcttttcct gtaaatactc ctaatactaa tatattttgc tttctagctt ttctcacttc
      241 attggctgta tctctcaaac caactatacc cctataagcc ttttctcctc ttaatgttct
      301 ctcactactt tttcctatct ttacatcatt tggtcttcca tcgctgagaa ctatcaggat
      361 tttattttct tcatctctat ttattagacc actacatata gattttattg ccaaaccatc
      421 tctattatta ccagcacaaa aatattcaaa tatattttca ctatttttta tactatcatc
      481 ataatcttta aatcttttta atattgtata gtctaaaaaa ctagaaaatc ccatcactct
      541 atttggtatg ccaacttctg ttagagcatt tgcaattatg taagcttgaa ttgccacatt
      601 tccctgattt ctactttgag agccacttgc atccaataat atatcaataa cgtatttccc
      661 tttttcattt tctatatctt tataaaatat tttattatta ttacttctac caactctcca
      721 agctctattt gctaatatag taccacaatc agaatatact ctacttttag cattttcttc
      781 tattaaaatt cttgatagac tttcttttaa tctctttatt tgctgtctat acattctagc
      841 atgttctcta aattttccta aattattttc tttttgtctt gttacatatt ttagttgaaa
      901 tacattatta cactcacttc taagaactcc atctgtaaag tgtattctac aaccttcatg
      961 aacatttcta caattttgtg tctcaatttt tttaatttca cctttactca aataagtttt
     1021 tccataataa tgttctattt ttgaatatat cttatttgca gtgtcttcat caacatatat
     1081 aactcggtct gctgaattgc tacatttaga atcatcaaaa tcccctacac cttctacaag
     1141 catggatgaa gatattgaat ctatatcact ttcaataata ttttcttctt catcactata
     1201 aagttcttca tacatgaaat cagcaaatgt atcaaaattt acttctacac tttctacatt
     1261 attttcatca ataagactat tttcttctcc atttaatatg tattcaaaat aagttaaata
     1321 tataacatct aatgctttta aaatctccat aatatcttga ttggtatcta tatttcttat
     1381 atcattaact attcttctag tcatactatc taatgctggg tgcttgtcca tactataaag
     1441 tacaaatgtg tatttaattt tatccataat attatcattg tgtattttgg taaaacgtga
     1501 aacaatatct ttataagcat ttcttcttat gtcttctatc cctggcctat ctttaatgac
     1561 cttttcttca actattgtat ttaatataac ttgaattaga cccagtataa tatctttgtt
     1621 gtatcctttt cttattctat ttgtaagata ttttttaact atatcccaat ctacatactt
     1681 tcttctagca cctgcaatta ttgcaaaata tagacctatt tcttttgaag agtaatcttt
     1741 ttctgatata tctatacttt cattgtaatc accagctatt gtccatgata agttattagc
     1801 tctattttca aattcataat catcatatat ccatttcata atctcaccta tattaaatat
     1861 gacttattgg aaacacatct atactctccc atttattagg tattctagtt ttaattacat
     1921 ctccaaccat ttctttctca tatacatcaa aagtctttcc tgtaagtccc atattaattg
     1981 caagagttgg ttttaatcct cttcttatag tcttaagaga tgccataaga ccacgtaaat
     2041 caatagcttt actagatatc tctccatttt gagacttcaa ttgtaaatct aaaaatattc
     2101 ctgcaaagtg tattagtttt tcttcatcag catctgaaaa ttcatttttt aaaatcatca
     2161 ttaacttatc ttcttctata ggaggaatat ctattaccat aaatctagat accagtgctt
     2221 cattaagttc ttttgttcct gcatattcat aattcatagt cccaataaat cttgttgctg
     2281 gatgtagatt gactctctca tacccaggta catcaattat tcttctatag tctaaagctg
     2341 aatgtaccac aactatagca tcattttttg ccatattaat ttcatcaaac accccaaaac
     2401 ctccattaat agcacactca taaactgagc ctcttctaag tttaacttca ttgtctataa
     2461 atgtatctgt acctataagt gttgaactgt ctgtatttat atgaaatgat gtattccact
     2521 gaggtctatt aaatatttcc cctagattat cagcaagtaa gttttttccc gttgcctttg
     2581 gtcccgataa taatatattt tcttcttcta aaatagctgc tatacacata gacaagatat
     2641 ctttaccata aaaataagtt ttagactttg ttactctgta ttctaaatct ttttctaatc
     2701 cataataatt tctaaaatac agtacatctt caataagttt ttcatctacc ccttgcaccc
     2761 ttagattatc tattatatcc atatttttac cccttttata taaatagtat ttgtttcatt
     2821 tcttatcacc attttagcat aaaaggatat aagctaaaat tgatttttta atctccccat
     2881 tttaagtaaa accatgcacc attttatcac tacaaaatta agagtactac ttactgatat
     2941 ttcttgattt tgttcgtcta tacgtatata atatatgctg ataaattatg aggaaaggat
     3001 gattgaaata tggaatatat gtcttgccca gaagtagcaa aaaaatgggg tatttctgaa
     3061 agaagagtac aaaaactatg tgaagaaagt cgcataccag gagtttcaaa actcgggtat
     3121 atgtggctga taccaaagaa cgcagaaaag cctgttgatg gtagaacaaa aagaagaaag
     3181 gaagtacaat atgaatagcg ttttgattat agatgatgac aaagaacttt gtgctcttat
     3241 gaaaaaatgt gttgagcaag aaaatttatc tgctattatt gcacattgtg gtgcagaagg
     3301 tctacatttg gtcgataaaa atagacacac actctctctt gtaattttgg acataatgat
     3361 gccagatata gacggttttc aagttctgaa aaaaattaga gaaacaagta atattccagt
     3421 aattatgctt actgctaaaa atgacgagga tgataaagtt tccggactac gtttaggtgc
     3481 tgacgattac ctaacaaaac cgttcagcat aaacgaactt atggctcgtg tcaattctct
     3541 tattcgtcgg tatactatgt taaaccctgc ttttataaca gacacagatt gcataataat
     3601 aaatggcatg attattgaca agacaaaccg aattgtttct gtcaataata ttcctgttca
     3661 acttacaagc aaagaatttg atttacttgc ttttctggct tctaataagg gacaggtgtt
     3721 taccaaaaaa cagatttata cacaagtatg ggaagaagaa tatgcttttg acgatagtaa
     3781 catcatgtct ttcatcagta aattgagaaa aaagattgaa ccagacccca accatccatt
     3841 ttatattttg acagttcgtg gtgtcggtta tcgttttaat aaggaggctt aacatgaata
     3901 caagtgtcta tctgcttttg atattggttc ttagcctgat tattatagcg taccttgttt
     3961 ctgtcctgct acgtgtccga atacaactta cacttataaa agatgcttta gaggatataa
     4021 aaaatggaaa ccttaatcga cgtattttaa cagatgaaaa cgacattaca aaacaaattt
     4081 gctatgatat taacgaaata gcaatcaata gccaatttca acttattcag caaaaacaat
     4141 cagaacaagc ctacaaacag ctaatgacaa gtctctccca tgatgtaaaa actccacttg
     4201 cttctttggt cggttatttg gaagcagtag aaagtaaaat tgttgtagga gaggaaaaag
     4261 acgagtatat ccatgttgcg tctaataagg ctcattactt aaagaatttt gtagaaaatc
     4321 tatttgaatg ggtaaaattg gattctaagg aacaagtttt tcattttgat atttttgact
     4381 tgaatgaatt atcccgtaat attatatctg attggatacc tgttttagaa agcagtcatt
     4441 ttgaatatga atttgatata ccagaaatag agtacttctt acgtatagac gcaaatgcat
     4501 atacccgtat cattaataac ctattacaaa atattattac ccatagtagt ggcaacaaaa
     4561 tgacattgag aatttttgaa aacaaagagc aagctcaaat tataataaca gataatggga
     4621 aaggtatatc ttcagacaat ctcccacata tttttgaaag gttgtaccaa tgcgaccatt
     4681 cacgagcttc aaagggaaat ggtttaggct tggcgattgc aaaggaactt attaacgctc
     4741 ataagggaaa tattaccgcc aacagcactc ccggtatggg aacagaattt acaatattgc
     4801 ttcctaaagc cctgtaaaag tacgaggctt tcttactcta aaacaagata aaagcaagat
     4861 tatggcaagg ttttggcaag gttcatgttt tataattcta attgtagttg attttgacgt
     4921 tgtatcaact atcttttgta gaaacaaatt tattaaaagt gaggaaatta tatatgaatg
     4981 attttgtgat tgaaacaaag caacttacaa aaatttatgg gaatcaaaca gtagttgaca
     5041 aagtcaatct ccatgtaaaa aaaggccgaa tatatggtct gttaggacgc aacggagctg
     5101 ggaaaaccac aattatgaaa atgattttag gattgacttc aatcacgtat ggcgaggtag
     5161 atgtatttgg agagaatatt aaggaacgtg aaaaacaagt atatccccgt atcggtgcaa
     5221 ttatcgaaac gccaggattt tatcctaatc tgacaggaac ggagaacttg gagatttttg
     5281 caaaactgcg tggtacagcc gcccctaatt ctgtaaaaag agcattggaa attgtaggct
     5341 taccttataa aaataaaaag ctgtttagta aatattcact tggcatgaaa cagcgacttg
     5401 gtattgccaa cgctatcctg catgacccag aactgttagt tttagatgag ccaaccaatg
     5461 gtcttgaccc tattggtatt gcggagatga gaaagtttat tagggacttg agcgttgagc
     5521 atggaaagac aattcttatt tccagtcata ttctttcaga aatctcattg ttggctgatg
     5581 atattggaat tatcgaccac ggtgttcttt tggaagaaag tagtatgagt gaactagaaa
     5641 agaaaaacag taaatatatc ctgctacaag tttcagatat tccgaagaca tcacttattt
     5701 tagagcgtca atttaacacg aaggattatt ccgttcaaga tgactacacg ttacaccttt
     5761 ataacactaa tctggatatg ggtgaaatca ataaagcact tgtaatgcag aatgtaactg
     5821 ttattagttc tcaactttgt aatgatactt tagaggacta ctttaaaaaa atcacaggag
     5881 gagagggcat tgcttaaact tattcaaaca gaatttctta aactgcgtcg taggaaactt
     5941 atttggctga tgttgttgtc tgctctcatt atgccgtttt tcgcactact atacttcaat
     6001 tattttggta aaacaggtgt tgagccaata aagttttata aatggtctgc atttggttat
     6061 acactttgga ttattttgcc tgttgttttg ggtatatttt gcaccatgct tatacacgaa
     6121 gaaaaccagt atgatatgct caaacagctt tggattgtac ctattagtaa aatgggatac
     6181 ttttttagta aatttttcgt tgttttgatt tactctattt gttttatgct gattacagcc
     6241 gttgcttctg tgttatttag tgtactttct ggatatgtcg tatttagctg ggcaagcatt
     6301 ttatatttgt tgaaaaaatg tttagaaatt ggtgtaatca ctgcttttgt aatgttgccg
     6361 attttggcaa tcgctacatc tcaaaaagga tacattctcc caatttgtat cacattggta
     6421 tatgcctttt ccggttttgt tataatgaca ataaatatgt atttacaccc attatccagt
     6481 atgggagtta ttatcatgag aaataaagac attccaggtc ttatattttc acaggaaatt
     6541 aatgtcccat tagcatttct ttgtatttgt atttggagta ttgtatcagt attgtttgca
     6601 aatattgcac taggaagaag aaagtgaggt gtagataatg tggaaattac tttgggctga
     6661 atgtcaaaaa attcgtcgtt caaaaattgt ttggattaca gtttttgcat ccattatgat
     6721 agcagtcata gtttttgcag gggggcagga tgtatataat gacccagatt tacattatgg
     6781 cttaaagagc gtttatgacg gttcacggta tatagacaat gcaggttggt atatggacgc
     6841 agtacaacct tggtcaactt tttttgttct tcctgctgtc attgccctat taggaagcta
     6901 tattatttgt cgtgaagaag aggaggacac tattaaatcc ctgcgtctta ttcccataaa
     6961 tgaaacaaat ttaaccatag caaaaatgat tattactttt atattcagta tacttcttta
     7021 tttgttactc tttactataa catttttgac tgaatccgtt ttacattttt ccgatttatc
     7081 gacaaaattg gttttaagtt gcatgaaaga gtattttctt gatggcatag gtgtattctt
     7141 tgcaatttct cccattattg ccttggtatc gcgcatgaaa aaaggatatt ggcttgcatt
     7201 agtattcaca gaagtttatt ctattgctgg actatttgcg ggtatgtcaa atgtcttaca
     7261 aacctttttt cctattgcgg caatatttaa tatttctgga tactatataa ctactggaga
     7321 aaaaattatg gggagtatca taagtttatt actttgtgcc tgcctttctg catttatact
     7381 taaagggcta aaacacaatg aaaaaaattg aaataggtat atcaaaatga aaaagataaa
     7441 aaaactgatt attctaattg tattcttgtt tctttttggc atgttacact gttatactga
     7501 atggaaattc aacaataacc cacctaaagg ggtaatagaa agaataaatg agtggactgg
     7561 attagtaact tatgttaatt atagtgaatg taatattagc aagttattgt ttcgtatttt
     7621 aatactataa ctttaaatat ttggttttaa tcttccaaac gaatataaaa aaactgtcac
     7681 agaggcaaca tatttttgaa tatttataaa gtggtagttt tgattttcaa agctaccgcc
     7741 ttttcttcta tataagcaaa cttatcctca acaaagtgta aaacatggta cattttaaga
     7801 aaaaagtacc acagacacaa gcaataaaag aaacgccgag aacctacaaa aacgtagtgc
     7861 ttatgcagat ttacgacgcc ttctattttc tcaaccgtct taatgacctt gtacaaaaga
     7921 aatttttcta atatttttta taatcttatc ttgtgatgtt ttttatgtat aaatgactta
     7981 ataacaaatc caataaaaat tatggatatt ggtataatta gaacgaggaa tttataatca
     8041 ttataatgtg acattattct tacccaactc tcagaaaaaa tatatcctat actgattaat
     8101 gaagtattcc atatggttat tcccacgata gatgatatta caaaagttat aatattttgc
     8161 cctgctatac ctgctataaa agatatgtat gttctacata aagggattaa tctacataca
     8221 caaacagaaa tagaagagta tttattaaaa taatcttgag atgcaaatat tcctttcttt
     8281 gcctttggac atatctctat tattttattt atgatagatt tacctcccca atttcccact
     8341 gtataacaaa atatcgaacc aagtatacct gcaattatac ttaaaattaa aattgtcaga
     8401 aatccaaaat gatttcttgc agcaattgct ccacataaag gtaaaacaac ttcgctaggt
     8461 aatggaaaac aagcatactc aatcataatt aatacaaata cagagattaa tccatattgt
     8521 aaaataaaac tattgattac agacacttac ttatctatct cctttcttat ttaaaggttt
     8581 taagggtaca tgttctaagg attctcaccc tatatttaaa gaatcaatct ctttaaacta
     8641 ttatatgtat ttacacaaag catttataac atactttaaa aatagtacct taaaataaga
     8701 aacttaataa a
//
LOCUS       DAEQCW010000133         8300 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.134, whole genome shotgun sequence.
ACCESSION   DAEQCW010000133 DAEQCW010000000
VERSION     DAEQCW010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8300)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8300)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8300
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.134"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(177..701)
                     /locus_tag="KRO40_003185"
     CDS             complement(177..701)
                     /locus_tag="KRO40_003185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBH2093983.1"
                     /translation="MENKNPIVTIEMENGKEIKIELYPNIAPNTVKNFVSLVNEGYYN
                     GIIFHRVIPGFMIQGGCPNGTGMGGPGHSIKGEFSGNGFTNNLKHERGVISMARTMAP
                     NSAGSQFFIMHKNSPHLDGQYAGFGRVIEGMDTVDEIASVRTDSADKPQTPQVMKSVT
                     VETFGIDYSDVEKN"
     gene            complement(766..1518)
                     /locus_tag="KRO40_003186"
     CDS             complement(766..1518)
                     /locus_tag="KRO40_003186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBH2093984.1"
                     /translation="MKLGLCLEGGGAKGAYQAGVVKALYDGGINKFYSISGTSIGAIN
                     GYYLYTGNVDNLEKMWTNIKDIQNGNVKIVNNTVDNSPAIDNLRELDDSNIEEMNFYV
                     NYVEVDNKVVSEKIVDVSKMPRNEAIISISYSGLLPSNPNATLGFKEQFVKDVQEGIY
                     DGFKLDGGLIRSALIEPLIGDNVDKIILISTKYNYELPEDIKKVYDEDKIIVVRPNTQ
                     FAPKDTLNFDDEFCKTIYQEGYEIGKNILDRL"
     gene            complement(1549..2847)
                     /locus_tag="KRO40_003187"
     CDS             complement(1549..2847)
                     /locus_tag="KRO40_003187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M18 family aminopeptidase"
                     /protein_id="HBH2093985.1"
                     /translation="MDSINFAKNLIDFIYDSPSSFHAVESTKEILDKNGFEELVLNQR
                     WNLRVGGKYYVTKNLSAIVAFVVNSEGIERDGFRIIGSHSDSPTFSIKPNAEIEAEKS
                     YLKLNTECYGGAILSTWLDRPLGIAGRVVLKGDSILKPNERLIDFKKPICIIPNLAIH
                     LNRSINDGHSYNKQKDMLPLVGMLNDTLEKDNFLIKQIASNLDVNMEDIIDFDLFLYE
                     FEKGSLIGANDEFISIGRQDNLAMVHASLNALVNTKGQHGVNVMAVFDNEEVGSSTKQ
                     GADSNMLLNILERICISMGKDREGFFESIYSSFMISSDLAHAIHPNIPEKHDPTNKPI
                     MGKGPVIKINASQAYTSDGYSIAIYKNICREANVEYQEFVNRSDERGGSTIGPISSTH
                     IDIPSVDVGSPILAMHSIRELGNVEDHYSIYKTFSKFFEI"
     gene            complement(2864..5128)
                     /locus_tag="KRO40_003188"
     CDS             complement(2864..5128)
                     /locus_tag="KRO40_003188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3553 domain-containing protein"
                     /protein_id="HBH2093986.1"
                     /translation="MNLDTLNPAQREAVEKTEGPVLILAGAGSGKTKVLTTRIAYLIE
                     DKGVQAPNILAITFTNKAANEMRERVEQNIGPETKDMWISTFHSCCVRILRKDINKIG
                     YNRSFVIYDSADQVTLVKDCLKELNLSDKVFEPKAVISAISGAKDKLYTPKQFKDINM
                     ADNRMVKIADIYALYQDRLKRNSALDFDDLILKTVELFKANDEVLAYYRSRFRYIMVD
                     EYQDTSKAQYELIKLLAREHQNICVVGDDDQSIYGWRGADIRNILEFEKDYDNVHVVK
                     LEQNYRSTQVILDAANKVISNNIERKRKKLWSEKKEGELIKIQLTGSEIEEADFIADS
                     IAQIARKENRPYKDFAVLYRANAQARPVEDALNRSQIPYNIYGGTKFYERKEIKDLLA
                     YLRVIQNPQDDISIKRIINVPRRGIGLRTIEKIEDRANLKQESIYSVLIDIETNSDIS
                     TKARASISGFVDIIGTLRTIKEVYPVSKLIEKVLDTTGYMDELVEIRNKNEKDLTGKG
                     EEAQDRIDNLREFISIALEFESSNDDTYENKDLETFLTSIALTSESNDEEDNDRVSLM
                     TIHTSKGLEFPVVFLTGMEEGLFPISRAIKSMSDSQIEEERRLCYVGITRAKEELYMS
                     LTEKRTLYGKTNVAIASRFMEELPEECIERLYKVKKELSYSKASYNMLDKYTKKYMST
                     ISKSKVADKVNATIKDSNKETNPDDIKLGSKVHHPKFGVGTVVSIIGTDVTIAFDQQG
                     IKKINKEYTTLNIL"
     gene            complement(5383..6201)
                     /locus_tag="KRO40_003189"
     CDS             complement(5383..6201)
                     /locus_tag="KRO40_003189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="HBH2093987.1"
                     /translation="MFKINNLTYQYEKNTNALLNINMDFSKGNVIGIIGSNGSGKSTL
                     FMNLMGILKPTSGEILFKEEKLKYDKRSLYNLRKNVGIVFQDPEKQIFYSKVYDDIAF
                     AMRNIGMDEKTIKERINKALVAVNGIDFIDRPVHFLSYGQKKRVAIASVIAMENEIVL
                     LDEPTAGLDPVSTRSIVDIIKGLNKNNIKIVISSHDMNLMYEICDYIYVLDKGILIDE
                     GKAENVFINENNIIQAGLESPWLVKVHRNMNLPLFKKEEDLYKYWKERELNTNK"
     gene            complement(6194..6892)
                     /gene="cbiQ"
                     /locus_tag="KRO40_003190"
     CDS             complement(6194..6892)
                     /gene="cbiQ"
                     /locus_tag="KRO40_003190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ECF transporter T component CbiQ"
                     /protein_id="HBH2093988.1"
                     /translation="MLIIDKYAYTNRLSKVNPNKKVAIGVIFLIASMVIQNIFILSGI
                     MILMSILVVCVAGIDLKNYLKLLRIPMYFLFLSIGITLVNISFNKADLLYSFEFFSFN
                     VGISKASIDMSIHVLFRAMSCLTCVYFCILTTPFNQLIFFFKKLHLPDTFVELSMLIY
                     RFIFIFLEEFSEIYKSQELRFGYINLKTSYKSLGILGSMLYKRLMTRYDDMCISLDIK
                     LYDGKFHIVGDNDV"
     gene            complement(6895..7173)
                     /locus_tag="KRO40_003191"
     CDS             complement(6895..7173)
                     /locus_tag="KRO40_003191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     substrate-binding protein"
                     /protein_id="HBH2093989.1"
                     /translation="MSAKTKTNILLLLLVVALIIFPLLVNSGAEYGGADGQAESEITK
                     INPNYKPWFSSPYEPPSGEIESLLFSAQAALGAGVIGYILGLQKGKRS"
     gene            complement(7163..7915)
                     /locus_tag="KRO40_003192"
     CDS             complement(7163..7915)
                     /locus_tag="KRO40_003192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter permease"
                     /protein_id="HBH2093990.1"
                     /translation="MKQNIKLGVIAALMLIILTPVTSNAMHIMEGYLPVKWSIAWGVI
                     FIPFFLFGLKSIGKIVKQDPKKKVLLALCGAFVFVLSALKIPSVTGSCSHPTGVGLGA
                     IMFGPSVMFVLGTIVLIFQALLLAHGGITTLGANAFSMAIIGPIVSFLIFKALKKKDG
                     NNAIPVFLAAAIGDLATYTITSIQLALAFPDPSGGVMASAIKFLGIFFMTQIPIAIAE
                     GILTVIVYNLITENGEKSILENNDKGVKANEC"
     regulatory      complement(8097..8289)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
BASE COUNT         2608 a         1512 c          897 g         3283 t
ORIGIN      
        1 ataaaacttt attttttagt taaaatcata caatatatag atttccacaa tacaaataaa
       61 ttaaaaagtg aaatgtattt gtctaaaaac ataataacat ttcactttat cctcattttt
      121 aagtaatata tatttttaat ttttatttat aactaaatct agtttttata taaattttag
      181 tttttttcta catctgagta atctattcca aaagtttcta cagtaacaga tttcataact
      241 tgtggagttt gtggcttatc agctgaatct gttctaactg atgctatttc atcaactgta
      301 tccatacctt ctatcactct accaaaacct gcatactgac catctaagtg tggtgagttt
      361 ttatgcatta tgaaaaattg agaaccagct gaattaggtg ccatagttct agccattgat
      421 atgactcctc tttcatgttt taaattgtta gtaaatccat taccactaaa ttcacctttt
      481 attgagtgac ctggaccacc cattcctgta ccatttgggc atcctccttg tatcataaat
      541 cctggtatta ctctatgaaa tattattcca ttgtaatatc cttcatttac taatgataca
      601 aagtttttaa ctgtatttgg agctatattt ggatataact caattttgat ttcttttcca
      661 ttttccattt ctatagttac tataggattt ttattttcca taatttatta ccttcctttt
      721 cattagttaa attacataat tacatttatt atattatact ctaaattaaa gtctatcaag
      781 tatatttttt cctatttcat atccttcttg ataaatagtt ttacaaaact catcatcaaa
      841 gttaagcgtg tctttaggag caaattgagt attaggtcta actactatta ttttatcttc
      901 atcatatact tttttaatat cttctggcaa ctcataatta tattttgtgg atattaaaat
      961 aattttatcc acattatccc caattaatgg ttcaattaat gcactcctaa ttaaacctcc
     1021 atctaatttg aaaccatcat aaattccttc ttgcacatct ttcacaaatt gttctttaaa
     1081 tccaagagtt gcgtttggat ttgatggtaa caacccactg tatgaaatgc tgataatggc
     1141 ttcattacga ggcatttttg atacgtcaac aatcttttct gatactactt tattatcaac
     1201 ttcaacataa ttaacataaa agttcatttc ttctatatta ctatcatcta gttcccttag
     1261 gttgtctata gcaggagaat tatccacagt attatttact atttttacat ttccattctg
     1321 gatatctttt atatttgtcc acattttctc caagttatca acattccctg tgtacaaata
     1381 atatccattt attgctccta ttgatgtccc tgaaatcgaa taaaatttat ttattcctcc
     1441 atcatacaag gctttaacta ctcctgcttg ataagcccct tttgctcctc caccttctaa
     1501 acataatcct aatttcatag tctcatctcc aaattgttta tcttatattt atatttcaaa
     1561 aaacttacta aatgttttat atatactata gtggtcctca acatttccta attctcttat
     1621 agaatgcatt gctaaaattg gacttcccac atccacagat ggtatatcta tatgagtaga
     1681 agatattgga cctatagtac ttcctcctct ttcatctgac ctattaacaa attcttgata
     1741 ctcaacatta gcttctctac atatattttt ataaatagct atagaatatc catcactagt
     1801 atatgcctga ctagcattta tctttataac cggacctttt cccattattg gtttattagt
     1861 tgggtcatgc ttttctggaa tgtttggatg aatagcatga gctaaatctg atgatatcat
     1921 aaaagatgaa taaatagact caaagaatcc ctctctatcc ttacccattg atatgcaaat
     1981 tctctccaat atatttaaca acatgtttga atctgcacct tgtttagtag agctaccaac
     2041 ttcttcattg tcaaatacag ccattacatt tacaccatgt tgacctttag tattaacaag
     2101 agcattcaaa ctagcatgta ccattgcaag attatcttgt ctcccaatag atataaattc
     2161 atcattagcc cctattaaac ttcctttttc aaattcatat aaaaataaat caaaatctat
     2221 aatatcttcc atatttacat ctaagttaga tgctatttgc tttataagaa aattatcttt
     2281 ttctaatgta tcatttaaca tcccaactaa aggtaacata tctttttgct tattatatga
     2341 atgaccatca tttatacttc tatttagatg tattgctaga tttggtatta tacaaattgg
     2401 ctttttaaag tctataagcc tttcatttgg ttttaatata ctatcacctt ttaaaactac
     2461 tctaccagct atcccaagag gtctatccaa ccatgtactt aatattgctc ctccatagca
     2521 ttctgtattt aacttcaaat aagatttttc agcttctatt tctgcatttg gtttaatact
     2581 aaatgtagga gaatctgaat gagagcctat tattctaaat ccatctcttt ctataccttc
     2641 tgaatttact acaaaagcta ctatagctga taaattctta gtaacataat actttccacc
     2701 aactcttaga ttccatcttt gattcaaaac taattcttca aatccatttt tatctaagat
     2761 ttccttagta ctctcgactg catgaaaaga cgacggacta tcatatataa agtctattaa
     2821 gtttttagca aagtttatac tatccattcc tcatttacct ccattataaa atatttagtg
     2881 ttgtatattc tttatttatt tttttaattc cctgttggtc aaaagctata gtaacatctg
     2941 taccaattat agaaaccact gtcccaaccc caaatttagg atgatgtacc ttagaaccaa
     3001 gttttatatc atctggatta gtttctttat tagaatcttt tattgtagca ttaactttat
     3061 ctgcaacttt agatttgctt atagtactca tatacttttt agtatattta tctaacatat
     3121 tataacttgc tttagaatag cttagttctt tttttacttt gtacaatctt tctatacatt
     3181 cttctggcag ttcttccata aatcttgaag ctatcgcaac atttgtttta ccatataatg
     3241 ttctcttctc tgtcaatgac atatatagct cttctttagc tctagttata ccaacataac
     3301 aaagtcttct ctcttcttct atttgtgaat cactcataga ttttatagct cttgatatag
     3361 gaaataaccc ttcttccata cctgttaaaa acacaacagg gaactctaaa cctttggatg
     3421 tatgaattgt cataagcgaa accctatcat tgtcttcttc atcatttgat tcagatgtaa
     3481 gtgctatact tgttaggaat gtctctaagt ctttattttc ataagtatca tcattactac
     3541 tttcaaactc caaagctata gaaataaatt ctctcaaatt atcaattctg tcttgagctt
     3601 cttcaccttt gcctgttaaa tctttttcat ttttatttct tatctctaca agctcgtcca
     3661 tatatcctgt agtatccaag actttttcta taagtttgct aacaggataa acttctttta
     3721 tagttctaag agtccctata atatcaacaa atccacttat acttgccctt gccttagtag
     3781 atatatctga atttgtttct atatcaatta atactgagta tatactttcc tgttttaagt
     3841 tagctctatc ttcaattttt tctatagttc taagccctat acctcttcta ggaacattta
     3901 taatcctttt tatagatata tcatcttgtg gattttgaat aactcttaaa tacgccaaca
     3961 aatcctttat ttcttttctc tcatagaatt ttgtaccacc atatatattg tatggaattt
     4021 gacttctatt taaagcgtcc tctacaggtc ttgcctgtgc atttgctcta taaagtactg
     4081 caaaatcctt ataaggtcta ttttcttttc tagctatttg tgcaattgaa tcagcaatga
     4141 aatcagcctc ttctatttcg ctaccagtta attgtatctt tataagttct ccttcttttt
     4201 tttcactcca aagctttttt ctttttcttt ctatattatt agatataact ttattagctg
     4261 catctaatat cacttgtgta gacctataat tttgttctaa ctttacaaca tgtacattgt
     4321 cataatcttt ctcaaattca agtatgtttc ttatatctgc acctctccat ccataaatac
     4381 tttggtcatc atctccaaca acacaaatat tttgatgttc tcttgctaat aattttatca
     4441 attcatattg agctttactt gtatcttgat actcatctac cattatgtat ctaaatctac
     4501 ttctgtaata tgctaatact tcatcattag ccttgaaaag ttctacagtt ttaagtatta
     4561 aatcatcaaa gtcaagtgca ctatttcttt ttaaacggtc ttgatatagc gcataaatat
     4621 ctgcaatctt aaccattcta ttatctgcca tattgatatc tttaaactgc tttggagtat
     4681 aaagtttgtc ttttgctcct gaaattgcac ttataactgc ttttggttca aacactttat
     4741 cacttaaatt taattctttt agacagtctt taaccaatgt aacttggtct gctgaatcat
     4801 aaattacaaa acttctattg taaccaatct tatttatatc ttttcttagt atacgaacac
     4861 agcaagaatg gaatgtactt atccacatat ccttagtttc aggacctata ttttgttcaa
     4921 ctctctctct catttcattt gcagctttgt ttgtaaatgt tatagctaat atatttggtg
     4981 cttgtacacc tttatcttct ataagatatg ctattcttgt tgttaatacc ttagttttac
     5041 ctgaaccagc accagccagt ataagtactg gaccttcagt cttttctact gcttctcttt
     5101 gagcaggatt taatgtatct aaattcatat ttctcctcct gttaacagcc ataaatatat
     5161 tttaatctaa aatatgaatt acttcaaatt ataattatgt attatattaa tagattattt
     5221 ccaatatatt acaattaaat aacatttttc catataattt atttcattgt ttaataaaaa
     5281 aaataacctt atgatttggg gaatcataag gcacctttaa ggggtctagg ttaagggtta
     5341 ttatatataa atctattttt ttaaaatagg tttagggctt aattatttat ttgtattaag
     5401 ttctctttcc ttccaatact tatacaaatc ttcttctttc ttaaataagg gtaaattcat
     5461 atttctatgt acttttacta accatgggga ttctaggcca gcttgtataa tattattttc
     5521 atttataaac acattttctg cttttccttc atcaatcaaa atccccttat ccaatacata
     5581 tatgtaatca catatttcat acattaaatt catatcatga ctggatatta ctatttttat
     5641 attattttta tttaatccct ttattatatc tacaatagac ctagtactta ctgggtctaa
     5701 accagctgta ggttcatcaa gtaatacaat ttcattttcc attgctataa ctgatgctat
     5761 tgccactctt tttttctgtc catagctaag aaaatgtact ggcctgtcta taaaatctat
     5821 tccattaaca gctactagag ctttgtttat tctctcttta attgtttttt catccatacc
     5881 aatgtttctc attgcaaagg ctatatcatc atatactttt gaataaaaaa tttgtttttc
     5941 tgggtcttgg aagacaatac ctacattttt tctaaggttg tataaacttc tcttatcata
     6001 ttttaacttt tcttctttaa aaagaatttc tccagatgta ggctttaata tacccattaa
     6061 attcataaat aatgttgatt ttcctgaacc atttgaacct attataccta taacatttcc
     6121 ctttgaaaaa tccatattaa tgtttaatag tgcattggta tttttttcat attgatacgt
     6181 taaattattt attttaaaca tcattatccc ctactatgtg aaatttacca tcatacaatt
     6241 ttatgtctaa tgatatacac atatcatcat accttgtcat aagtcttttg tacagcatac
     6301 ttccaagaat acctaaggat ttatatgaag tttttaaatt tatatatcca aatcttagct
     6361 cttgtgactt gtatatttct gaaaattctt ctaaaaatat gaatataaac ctatatatta
     6421 acattgataa ctcgacaaaa gtgtcaggta aatgaagttt tttaaaaaag aatattaatt
     6481 gattaaaagg tgttgtaagt atacaaaaat acacacaagt caaacaagac atcgctctaa
     6541 ataacacatg aatagacatg tcaatagacg cctttgatat tcctacatta aaactaaaaa
     6601 attcaaaact atataataaa tctgctttat taaaagatat atttacaaga gttattccta
     6661 tactaagaaa taaaaagtac attggtattc taagtaattt taaataattt tttaaatcta
     6721 ttccagccac acaaacaacc aaaatactca ttaaaatcat aattccactt aaaataaata
     6781 tattttgtat taccatagaa gcaatcagaa aaattactcc tatggctact tttttgtttg
     6841 gatttacttt actcaatcta tttgtatatg catatttatc aattataagc atgattaact
     6901 tctctttcct ttttgaagac ctaatatgta tcctattaca ccagccccta aagctgcttg
     6961 tgcagagaat aataaacttt ctatttctcc acttggtggc tcatatggac tgctaaacca
     7021 tggtttgtaa tttggattta tcttagtaat ttcactttca gcttgaccat ctgctcctcc
     7081 atattcagca cctgagttga caagtaatgg gaatataata agagctacta ctaataaaag
     7141 taataatatg ttagtttttg ttttagcact cattagcttt aactccttta tcattatttt
     7201 ctagtatgct tttttctccg ttttctgtaa ttaaattata tacaattaca gtaagtatac
     7261 cttctgctat tgctattggt atttgagtca taaagaaaat tcctaaaaat ttaattgctg
     7321 aagccattac cccacctgat gggtctggga aagccagtgc taattgtatt gaagttattg
     7381 tatatgtggc taagtctcct attgctgctg caagaaatac tggaatagca ttatttccat
     7441 cttttttctt taaagcctta aatattagga atgatacgat tggccctatt atcgccattg
     7501 aaaaagcatt agctcctaaa gtagttattc ctccatgtgc taataacaat gcttggaata
     7561 ttaaaactat agttccaaga acaaacatta cgcttggtcc aaacattatt gctccaagac
     7621 ctacaccagt aggatgtgaa caacttcctg ttactgaagg tatttttagt gctgataata
     7681 caaacacaaa tgctccacat aaagctaata atactttctt tttagggtct tgctttacta
     7741 ttttacctat tgattttaat ccgaataaga aaaatggtat aaatataact ccccatgcta
     7801 tagaccattt tactggtaag taaccttcca ttatatgcat tgcatttgat gtaactggag
     7861 ttaaaatgat taacataagt gcagctataa cccctaattt aatattctgt ttcatcttag
     7921 tatccctctc tccctttcta ataattaaaa cataataata catgtctgat ttatttaata
     7981 aaataaaaaa gcctaactcg atggttaggc ttctaatttt ccacaatcta aatacaaaca
     8041 cataaaacaa acatatctgt ataattatta taagaaactt tctccatccc cgaagaaatt
     8101 actttaatat tttaggcagg tctcctgact tagcttcatc ctactcctct tccttcccat
     8161 gagatataaa aaatatcatc atagtggcta acaaaagttt cgtctgcatc acagtagcgg
     8221 gggctgtaaa ggaatttaac ctttttccct attaatcttg cttaaagaac ctataatatt
     8281 atatatttaa tttttaaatt
//
LOCUS       DAEQCW010000134         8070 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.135, whole genome shotgun sequence.
ACCESSION   DAEQCW010000134 DAEQCW010000000
VERSION     DAEQCW010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8070)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8070)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8070
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.135"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(29..241)
                     /locus_tag="KRO40_003193"
     CDS             complement(29..241)
                     /locus_tag="KRO40_003193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2093991.1"
                     /translation="MAILMKTKIKEYREKLLMTQNELAKLVGVRRETIVHLENGKYNP
                     SLKLAMDIAKVFDTTVENLFEFIEEE"
     gene            complement(242..658)
                     /locus_tag="KRO40_003194"
     CDS             complement(242..658)
                     /locus_tag="KRO40_003194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093992.1"
                     /translation="MSKSETGVRSKLILELLVITYFFIAVLATKYIFKGPSTASLPGL
                     SWLIVFGCYSIYNKKYNDLVDESSEFILSKVNKIAIKIMIYSIVIISIFFATPYTSNI
                     NISNLDTGIILIAVLFIQSLSKLVLYIYFDKRGICN"
     gene            complement(726..1139)
                     /locus_tag="KRO40_003195"
     CDS             complement(726..1139)
                     /locus_tag="KRO40_003195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2093993.1"
                     /translation="MSKSELGVKTNLVSELLMISYFFIDSLLKKFIFKEGNLCITFII
                     LFAFWACDFMYNKKYNDLVDEASKLMLLKVDHIASKIMLYSILLIAVFFSANYTRGLD
                     ISNLDIGVILLAILFIQSLSKLILYIHFDRKGICN"
     gene            complement(1972..2601)
                     /locus_tag="KRO40_003196"
     CDS             complement(1972..2601)
                     /locus_tag="KRO40_003196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine amidotransferase"
                     /protein_id="HBH2093994.1"
                     /translation="MKNRKVYMYVFDTMSDWEVAYLTAELNTGRYFKKGLKPLKVITV
                     GIDKNPIITMGGLKVLPEITVDEFNMESKDLLILPGGNTWLSMNHEIILEKVKEALRQ
                     DSIVAAICGATLGLAKKGLLDFRNHTSNDLEFLKMVIPNYSGEKYYKTESVVSDENLV
                     TASGIAPLEFTFQVLKLLDVFESEALNSWLNLYKTHDSKYFFELMNCNK"
     gene            complement(2680..3642)
                     /locus_tag="KRO40_003197"
     CDS             complement(2680..3642)
                     /locus_tag="KRO40_003197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017561613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBH2093995.1"
                     /translation="MAKIDNMMSILWMLNSDKKITAKQIAEKLEINIRTVYRYIDVLS
                     ASGVPIISDTGHNGGYSLLNNFTKAPLFFDIEEQKSLLHAALFAKKEGYFLDEALDKS
                     ILKLKMYSNQKQEDILTNHLRALEVIKPIGKVSIESVLKKLENSILKELSVEINYHAG
                     RKVKSKYRIINPYGIVHWNNNWYVVAFCNMRNEVRSFRVDRISEIIETSNTFNRPTEF
                     SASEFFIKGIIPEIKDEQNIIQLVIEGSIDSLDSLSQHWFLGHYLKERTPNKIIFMLE
                     EEVICKYIPNILLPYRKTIQVIEPLSLRKKIIEDLLELIDYYQI"
     gene            complement(4404..8000)
                     /gene="cbpA"
                     /locus_tag="KRO40_003198"
     CDS             complement(4404..8000)
                     /gene="cbpA"
                     /locus_tag="KRO40_003198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-binding adhesin CbpA"
                     /protein_id="HBH2093996.1"
                     /translation="MQQKCKKKALSMILSISMGLGSVASFNASNTFADTIEESTNAGN
                     AEGDTNAGNAGGDANAGNAEGDANAGNAGGDTNVGNPEGDANAGNAGGDANAGNAEED
                     ANAGNAEEDANAGNAEGDANAGNAEEDSNAGNAEEDSNAGNAEGDMNALVVEEATAED
                     PTSVGDFKISGGEINVDFKFASGVLTILSGKQMTIQNNNPNTPTTHRIVIPKDVKAEL
                     IFDGVNIKTASNSPFTLTPDKDGGAYAHVILQDGSENKLESGDVYYPGMRAGKGTTLI
                     IDDSVVNRDIEGEFIVSEGGKIPRDVTLENGDKLKKGDRLTLLDSNNRGSLKVVGNYY
                     SAGIGGGNTESGGNIIINGGAITAIGQESSRNTGYGAGIGGGGNGSGGDITINGGTIT
                     AKGAYHGAGIGGGYYTTTKNALSPSVVDPSTGSGYSGNITINGGLSYSYGGAHGSAFG
                     DGCVNPGTNRGYRILVTGGTILPYMTGVGDWIFDLSATTGDVIVTGGSLKATTFKSLG
                     GAVAYGDLEKKTKVFMNKISLTYLGQDKVSTTLVDDFKMLIDGKIYPYGAPSYTDAQG
                     ILYLWFSDKFTGSEVSVNLVVIDKITGEVLKPDDFYIKDIGSGSQFLKQYEEFTIDDT
                     PPYLIIKRYDGLPFEEDVEKSFLDWLLKDGGIPITTPKGEKLTDKKFMTISSQRLNEE
                     TMEPDINLGSDDLTKQVDAGKYQLSITSTQFSSIYPFKDAYWGHRAYYKAEIIPADTE
                     TSLVVEESKAKTDVFKPTDTFTLNVTISPDKKEGPDCASPRGYVQFYINGKEYKDPVE
                     LKTHNKGSESHNYSTASIEWRPLDSNHHIFTTEQTITVKYIGDDINYIEGSEDEKKLK
                     LDMTNVDVDGDGIPDINIDTDGDGRPDINIDTSGDWKPDINIDTDNTGEWKPSTEGGN
                     GDGIWKPDKNIDTNGDGNPDTDYNRPAIDTDNDGVDDYWKPDKNVDTGSGGYDTGNPN
                     LNKPDPDNGGNSKPDSGNGGNSKPDSGNGGNSKPDSGNGGNSKPDSGNGGNSKPDPDN
                     GGNSKPDPDNGGNGKPDPDNGGNSKPDPDNGGNSKPDPDNGGNSKPDIDTDGDGKPNI
                     NIDTDGDGKPDINIDTDGDGKPDINIDTDGDGKPDINIDIDGDGKPDINIDTDGNGKP
                     DINIDTDESLDSNVGQNVQTGDQSNIMLDLALMFISLFFLIKNLTNKYLRRK"
BASE COUNT         2558 a         1498 c          863 g         3151 t
ORIGIN      
        1 catcttataa atgtttataa actttccact attcttcttc aataaattca aacaaatttt
       61 ctactgtagt atcgaatact ttagcgatat ccatagctaa cttcaaagaa ggattatatt
      121 tcccattttc taagtgtaca atagtctcac gtcttacccc aaccaattta gcaagttcat
      181 tttgcgtcat aaggagtttt tctctgtatt ctttaatttt tgttttcatc aatattgcca
      241 cttagttaca tatccccctt ttatcaaagt atatatacaa cactaattta gataaagact
      301 gtataaataa aactgcaatg aggattatac ctgtatctag gtttgatata tttatattac
      361 ttgtataagg tgttgcaaag aaaatagata ttattactat agaatatatc attattttta
      421 ttgcaatctt attaaccttt gatagtataa attcagatga ttcatcaact aaatcattat
      481 attttttatt ataaattgaa taacatccaa aaactattaa ccaactcaac cctggaagag
      541 aagcagtgct tggaccttta aaaatatact tagtggctaa tacagctata aaaaaataag
      601 ttattacaag caactccagg ataagctttg atcttacacc agtttctgat ttagacatat
      661 aaaatcactc cttaaaaatt atattctcta tactctttaa ttttcgtttt tatcaatatt
      721 atcacttagt tgcatattcc ctttctatca aaatgtatat acaaaattaa tttagataaa
      781 gattgtataa ataaaatagc taagagaatt acacctatat ccaaatttga tatatccaaa
      841 cctcttgtat aatttgctga aaagaaaaca gctattagca aaatagaata taacattatt
      901 tttgatgcaa tatgatcaac ctttaataac ataagttttg acgcctcgtc aactaaatca
      961 ttatattttt tattatacat gaagtcacat gcccaaaaag cgaataaaat tataaaagta
     1021 atacaaagat ttccctcttt aaaaataaac ttttttaata atgagtctat aaaaaaatag
     1081 gatatcataa gtaactctga aacaagattt gttttaacac caagctctga tttagacata
     1141 taaaatcacc ccttaaaagt tatatattta taacacctta tgttataaat atataacttt
     1201 tccaaataaa ttgcaataga atattgaaaa tattcaataa tatcttcata aatatatttt
     1261 ataaaagatt ttataataaa cattacaata cagtactaaa ttagtttatt tcatctatca
     1321 tctcaatcat atcatttact aactattatt ctaatgagca tataacattg aaacttataa
     1381 ttatacaacc taaatgcctc ccaatgtacc ctcaaaacat catttcctgt aactgaagta
     1441 taattggtat attttatcac tgaaataaaa aaacactagt caataaagac tagtattttc
     1501 aagtatttta tcattctttt tttaattatt ggagacgaat catcagaata atgcccataa
     1561 tttatctata tgcaaattct aaatttaaaa taaagtttca gataaattta ctattctatg
     1621 ctatgataca acagaaaaaa ctgaaatcta tgagtggtag cttcatataa tcctagttcc
     1681 tacagtaatc aaaactgagg tttattctat atgtaactaa tgataaattt tattatagga
     1741 gttattagat ctatttgtgt tactataagt agtaattata tatatgataa ttttttaaca
     1801 cttttctgtt ggctatatag aaagtggttt agaatttaaa tttaaataaa atttaaattc
     1861 accaaaaaga aatctatatt agaaaccact actctattcc accagattgt aattttttgt
     1921 tctttatatc acaatgctat accatattaa attgaaaaat aagttttaaa tttatttgtt
     1981 acaattcatt aattcaaaaa aatattttga gtcatgagtt ttgtaaagat ttagccatga
     2041 atttaatgct tctgattcaa aaacatctaa aagtttcaat acttgaaacg taaattccaa
     2101 cggagcaatt cctgaagccg taactaaatt ttcatcacta actacagatt ccgttttata
     2161 atatttttct ccagagtaat ttggtattac cattttaaga aactctaagt cattacttgt
     2221 atgatttcta aaatctaata gccctttttt agctaggcct aatgtagctc cacatatggc
     2281 tgcaactata gaatcttgtc ttaaagcttc tttaactttt tctaatatta tctcatgatt
     2341 catagataac caagtatttc cccctggcaa aattaataaa tccttacttt ccatattaaa
     2401 ctcatcaact gtaatttcag gtaaaacttt taacccaccc attgttataa taggattttt
     2461 atcaattcct acagtaatta cttttagtgg ctttaatcct tttttaaaat atcttcctgt
     2521 atttaattca gcagttaaat atgccacttc ccaatctgac atagtatcaa atacatacat
     2581 atatactttt ctatttttca tcttttttac tccttatgta attaatttat atatctaatt
     2641 ataaaataac ttaactgaca tattcagtca gttaagctat taaatttgat aataatcaat
     2701 taattctagt aaatcttcaa ttattttctt cctaaggctt agtggttcaa ttacttgtat
     2761 tgtctttcta taaggtaaaa gtatatttgg tatgtacttg catattactt cctcttcaag
     2821 cataaatatt attttattag gtgttctttc tttcaagtag tgccctaaaa accaatgttg
     2881 gcttaaacta tctaaagaat ctatactccc ttctataact aattgaatta tattttgttc
     2941 atcttttatt tcaggtataa ttccttttat aaaaaattca cttgctgaaa attctgtcgg
     3001 tctgttaaat gtatttgatg tttctatgat ttcactaatc ctatccactc tgaaactacg
     3061 aacctcattt ctcatattac aaaatgcaac tacgtaccaa ttattattcc agtgaacaat
     3121 tccatatgga tttataattc tatattttga ttttacttta cgacctgcat gatagttgat
     3181 ttctacagat agctccttta atatactatt ctccaatttt ttaagtactg attctataga
     3241 cactttccca attggtttta ttacttcaag ggctcttaag tggtttgtta aaatatcttc
     3301 ttgtttttga tttgaataca tttttaactt taatatcgat ttatctaatg cttcgtctaa
     3361 gaagtatcct tcttttttag caaatagtgc tgcatgaagt agagattttt gctcttctat
     3421 atcaaaaaaa agaggtgctt tagtaaaatt atttaaaagg ctatacccac cattatgacc
     3481 tgtatctgaa attataggta ctccactcgc agaaagtaca tcaatatatc ggtacactgt
     3541 tcttatattt atttctaatt tttcagctat ctgttttgct gtaatttttt tgtcagagtt
     3601 taacatccac agtatagaca tcatattgtc aattttagcc atgtagtttc acctctttct
     3661 atttgttata taaagttatt atataacttt ttgattgatt ttttacaaaa aaacattagt
     3721 aaactgctaa taatttatac taagatttat ttcaaatatt tatagatagt ctttttctat
     3781 agttaagtta tccattaaat tacatagtag tatatctatt ttagttgata tattttcagc
     3841 tacctccctt gaatattatt acaataagtc taaatcttct ttcttccata aatatattat
     3901 gaggaaagac tatcatcttt aatggtttaa tagtataaaa gatattaatt taaaaaaatc
     3961 tatttttata tcagatgggt attgtttttt ataaaactga aaaaatcacc taatagaatc
     4021 tatgattttt taacataacc tccataaatt agttccaatt atcacttcaa attcaaattt
     4081 ttatctgaag aatatacaat catatttcca tactcaacat aatattgagt gtttggcttg
     4141 tatttacaaa ttattattct aacaaaaaca actatacata gattaaaatc atcttctaaa
     4201 cataactact aaaattgaat taatgatatc aattccatta atctctttta ataaaaaatt
     4261 ctcttttcta tatgaaaatt atttcaaaac ttttaagtta aatacaaaaa tgactataaa
     4321 tagattttta tttacacaaa tctatttata gtcactatag tttatccaat aaaataataa
     4381 aataaatatg tacacaataa atgttattta cgtcttaagt atttatttgt tagattttta
     4441 attaaaaaaa acaagctaat gaacattaat gctaaatcta gcattatatt gctttgatct
     4501 cctgtttgta cattttgacc tacattacta tctaaacttt catctgtatc tatatttata
     4561 tctggttttc cattcccatc tgtatctata tttatatccg gttttccatc tccatctata
     4621 tctatattta tatctggttt tccatctcca tctgtatcta tatttatatc tggttttcca
     4681 tctccatctg tgtctatatt tatatctggt tttccatctc catctgtgtc tatatttata
     4741 ttcggttttc catccccatc tgtatctata tctggtttgc tatttcctcc attatctggg
     4801 tctggtttac tatttccacc gttatctgga tccggtttgc tatttcctcc attatctgga
     4861 tctggtttac cattgccacc gttatctgga tctggtttgc tatttcctcc gttatctgga
     4921 tccggtttgc tatttcctcc attacctgaa tccggtttgc tatttcctcc attacctgaa
     4981 tccggtttgc tatttcctcc attacctgaa tctggtttgc tatttcctcc attacctgaa
     5041 tctggtttgc tatttcctcc attatctgga tctggcttat ttagatttgg attacctgta
     5101 tcataacctc ctgagccagt atctacattt ttatcaggct tccaataatc atctactcca
     5161 tcattatctg tatctattgc tggacgatta taatctgtat cagggtttcc atctccattg
     5221 gtatctatat ttttatcagg tttccaaata ccatctccat ttccaccttc tgtactaggc
     5281 ttccattcac ctgtattatc agtatctatg ttaatatctg gcttccaatc accactcgta
     5341 tctatattga tatctggcct tccatcacca tcagtgtcta tatttatatc cggtattcca
     5401 tccccatcta catctacatt tgtcatatct aactttaact tcttttcatc ctcactacct
     5461 tcaatgtaat ttatatcatc tccaatatat tttacagtaa tagtttgttc agtagtaaaa
     5521 atatgatgat tgctatctaa aggtctccat tcaatagatg cagtactata attatgactc
     5581 tcactaccct tattatgagt ttttaattct actggatctt tatattcctt tccattaata
     5641 tagaattgta cgtaacctct tggagaggca caatctggtc cttctttctt atctggtgaa
     5701 atagtaacat ttaatgtaaa cgtatctgtt ggtttaaaaa catcagtttt agctttagac
     5761 tcttctacaa ctaatgaagt ttctgtatca gcaggaataa tttctgcctt ataatatgct
     5821 ctatgccccc aataagcatc cttaaaagga tatatactcg aaaactgtgt tgatgtaatg
     5881 cttaattgat atttcccagc atcaacttgt tttgtaagat catcacttcc taaatttata
     5941 tctggttcca tcgtttcctc atttaaacgt tgagaactaa tagtcataaa ttttttatct
     6001 gtgagttttt cacctttagg agtagttatt ggaataccac catcttttaa tagccaatct
     6061 aaaaatgatt tttctacgtc ttcttcaaat ggtaatccat catatctttt aataatcaaa
     6121 tatggtggag tatcatcaat agtaaattct tcatattgct ttaaaaattg agaacctgaa
     6181 cctatatctt taatataaaa atcatctggt tttagaactt ctccagtaat tttatctata
     6241 acaactaaat taacagatac ttcagatcca gtaaatttat cagagaacca taagtaaaga
     6301 atcccttgag catctgtata actaggtgct ccataaggat aaatttttcc atcaattagc
     6361 attttaaaat catcaactag tgtagtacta actttatctt gccctaaata cgttagagat
     6421 attttattca taaaaacttt tgttttcttt tctaaatcac cgtatgcaac tgctccacct
     6481 aaacttttga atgttgttgc ttttaatgaa ccacctgtta ctataacatc tcccgttgta
     6541 gcacttaggt caaaaatcca atctcccact cctgtcatat aaggtaaaat cgttcctcca
     6601 gttacaagta tacgatatcc tctatttgtt cctggattaa cacatccatc cccaaatgca
     6661 ctaccatgtg cacctccata tgaataggaa agtccaccat taattgtaat attcccacta
     6721 taaccagaac ctgtgctagg atctactact gagggactta atgcattctt tgttgttgta
     6781 tagtatcctc cacctattcc agctccatgg tatgcacctt tagcagttat agtaccacca
     6841 ttgattgtga tatctccacc actaccatta ccgcctccac ctattccagc tccatatcct
     6901 gtattacgac tcgattcttg acctatagca gttatagcac caccattaat aataatattt
     6961 cctccacttt cagtatttcc accgccaata cctgcagaat aataatttcc aacaactttt
     7021 aaacttcctc tattattact atctagtagt gtaaggcgat ctcctttttt taacttgtct
     7081 ccattttcta gagttacatc tctaggaatt tttccaccct cagaaactat aaactcgcct
     7141 tcaatatctc tatttacaac agaatcatca ataattagag tagtaccttt tcctgctctc
     7201 atacctggat aatatacatc acctgactct agcttgtttt cactaccatc ttgtaatata
     7261 acatgtgcat atgcaccacc atctttatct ggtgttaaag taaatgggct attagatgca
     7321 gttttaatat ttactccatc aaatattaat tcagctttta catctttagg tataacaatc
     7381 ctatgtgttg ttggagtatt tggattatta ttttgaattg tcatttgttt tccactaaga
     7441 atagttaaaa cgccacttgc aaatttaaaa tcgacattta tttctccacc actaatttta
     7501 aagtctccta cagatgtagg atcttctgca gtggcttctt ccacaactaa tgcattcata
     7561 tctccttctg catttcctgc attagaatct tcttctgcat ttcctgcatt agaatcttct
     7621 tctgcatttc ctgcattagc atctccttct gcatttcctg cattagcatc ttcttctgca
     7681 tttcctgcat tagcatcttc ttctgcattt cctgcattag catctcctcc tgcatttcct
     7741 gcattagcat ctccttctgg atttcctaca ttagtatctc ctcctgcatt tcctgcatta
     7801 gcatcccctt ctgcatttcc tgcattagca tcccctcctg catttcctgc attagtatct
     7861 ccttctgcat ttcctgcatt agtactttct tctatagtat ctgcgaaagt atttgacgca
     7921 ttaaatgatg ctactgatcc aagtcccatt gagatactta aaatcattga tagtgctttc
     7981 tttttacatt tttgttgcat aaattccccc tccccttaat aatttttaat atacactgta
     8041 tacatcctta tatacactct aataattctt
//
LOCUS       DAEQCW010000135         8021 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.136, whole genome shotgun sequence.
ACCESSION   DAEQCW010000135 DAEQCW010000000
VERSION     DAEQCW010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8021)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8021)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8021
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.136"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            95..769
                     /locus_tag="KRO40_003199"
     CDS             95..769
                     /locus_tag="KRO40_003199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2093997.1"
                     /translation="MFKIMVVEDDVSLKNIIAKCLTKWGHDVHQIENLENIIEEFKNY
                     NPELVLLDINLPFYDGFHWCNEIRKISKVPIIFISSRNSNMDVIMGVNLGADDYIQKP
                     FSVDVLVAKVNALLRRTYNFVDNNSNQIIHNGVTLDLSTATINYEDNTIELTKNEIKI
                     LHELMKYKGQIVSRNKLMKKLWDNDWFVDDNTLTVNVNRIRSKLNEIGLEDFIETKRG
                     LGYIIS"
     gene            793..1797
                     /locus_tag="KRO40_003200"
     CDS             793..1797
                     /locus_tag="KRO40_003200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2093998.1"
                     /translation="MSFKDFLKDKLGFLVYNFTFLIFTVSVIIFSPVDVFLTDTILYI
                     LVVNVVFLFLYLFISYIKKNKFLDKIKNDTFKINMNDIELARCKNEEKIYLNIIKNHQ
                     YQCNNIINNNIEKFEENKEILNMWVHDVKIPIAIIKLILEQNENLIDEKISDDIDSEI
                     FRIENSVEKILYLSRLEDFHKDFLIQEVNIEKIIRNIIKKYSKYFISKKIILDLNNLN
                     FKVLSDEKWLYFIFEQLLSNSLKYSSLGDNISIYCKRTKNYLQLRVEDTGCGIKKEDL
                     NRIFNKGFTGNNGRNNSKSTGLGLYLVKELCDKLGHKIDVDSEYNQYTKFTITFKCDL
                     "
     gene            1909..3138
                     /locus_tag="KRO40_003201"
     CDS             1909..3138
                     /locus_tag="KRO40_003201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBH2093999.1"
                     /translation="MSFLKKFKNKRFRNNSFKSNNFRNSSFGSSGFKSKNKGFKNNPF
                     KNKRFKIYAGIAVIILLILGVLAYVDSKNTELQANENFIETYTIPENEKIFINGMVVP
                     KQTKDFNISGDYELSDVNVTNGQKVNQGDLLFTAKNPTIIAEIDSLKSQLSQYKKQKI
                     SLSDIAENKDAIASINAQITALNSQIASLDKKAYDRVTAPFDGTVYLNDQTGNPDQPV
                     SFMTIQGLEFYMKGQASEQDLPKMKIDQMVNILVFSTDQKLTGRISFISDKPSTPNTE
                     MGAQQNTLSYYDINIAFDNQEGLVNGFHLQASLEVANSSFKIPASCVLKDNKHSYVFK
                     DLDGILKKQIVDVASQNDDFAVVRGGLEQGDIIIKHPTKEMKEGDPVQGDGVTAGSNN
                     GDTTPNKKVEEVTMDVN"
     gene            3146..3820
                     /locus_tag="KRO40_003202"
     CDS             3146..3820
                     /locus_tag="KRO40_003202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094000.1"
                     /translation="MLIKLENIQKYYKVGKDELHVLKSLNLEIESGEFVMIMGKSGSG
                     KTTLLNILGFLDVFDEGRYIFDGTDVTNLSENERSVFRNINIGFVFQQFNLIETLNVY
                     QNVELPLIYNKALKKSNREEIVKDKLSSVGLLDKLKQKPLQLSGGQQQRVAIARCLAN
                     DPQIIFADEPTGALDSETSREIMELLTRLNKQGKTIIMVTHDQDLTKYATKVIRLKDG
                     VFTSEV"
     gene            3823..5055
                     /locus_tag="KRO40_003203"
     CDS             3823..5055
                     /locus_tag="KRO40_003203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094001.1"
                     /translation="MSLLKNSLANLKGHKLRVFVALLWIIIGITSVILVSSIGNGFQK
                     EIKKSVNNVNPNKTTISFESADNTGLTDDMSIFLKPFNAKDLEELSFVEGVERIAPSR
                     DGFNLDSVYSSQASFDKKTTYVDVGPVKKDSKINLICGRDFSLDDEKRKVILLTLQST
                     SEIFENPEDALGHGININGTIFEIIGVLDDSQQNQAGGFFGGYQDMQFTTSLVPKKAF
                     DTLMSQNSYSNEIYQLDLVSSKGYNVNEVANNVIAKLYEMHPGINGSYTTPDPTEQTA
                     YLESINSNVNKYVSIITVVAMFVGGIGVMNIMYVSVMERQREIGIRRAIGAKPRSILF
                     QFLVEAVFITVCGGILGTIVGFAATNYVSKYIGFEAIPSLNSLFYAIVATILTGVVFG
                     LIPAFKASKLDPIKAIYK"
     gene            complement(5341..6606)
                     /locus_tag="KRO40_003204"
     CDS             complement(5341..6606)
                     /locus_tag="KRO40_003204"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HBH2094002.1"
                     /translation="MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKI
                     IDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKSAARGGFTTVICMANTNPIVDNE
                     DTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
                     IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCM
                     LALKTGAKVDIQHISSGVSVDMVRFAKYLGANVVAEASPHHFTLTEEDVLEFGTNAKM
                     NPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKAPSGIIGLETSLALG
                     ITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVS
                     KADNSPFKGKSLYGKVNYTICNGEIVYNA"
     gene            complement(6659..7807)
                     /locus_tag="KRO40_003205"
     CDS             complement(6659..7807)
                     /locus_tag="KRO40_003205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBH2094003.1"
                     /translation="MKSVSVRSCKTYNYEEVKLSIEKNLEDIGGIDKFVKKGSKVLIK
                     PNLLMKKKPEEATTTHPMVVKVVCEKLLELNCDITIADSPGGPYNQSSLKSIYKASGI
                     EEVANELGIKLNYDVSDVKIHSEKAHVLKYMDIIKPIVDSDYIINLCKLKTHIMATFT
                     GGTKNLYGCIAGLKKAEIHYRFPTEELFCENVLLDICDYIKPTLTIMDGIVGMEGDGP
                     SAGTTREIGVLLASQNPYAIDVVACKIISLLPNRVATIRGAIKRGYIQEDFSDIEILG
                     EDIKDLIIKNYKIPNVSKDLRLFSVKLPKFLNEPISKLITPKPVVRFQDCIKCGKCKE
                     ACPASTIEIGTKGAIIDLSKCIRCYCCHELCPKKAIDVKRNFVFKYVK"
     gene            complement(7907..>8021)
                     /locus_tag="KRO40_003206"
     CDS             complement(7907..>8021)
                     /locus_tag="KRO40_003206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBH2094004.1"
                     /translation="AKELGLDAIHDTVHEMCKDEARHGKAFLGLLNRHFGK"
BASE COUNT         2890 a         1173 c         1117 g         2841 t
ORIGIN      
        1 atataattat tttaggtaat aaggtagaaa tattttaatt tatcaagtag aatatagtta
       61 tgttaatata actattttga attaggaggt aagaatgttt aaaataatgg tagttgaaga
      121 tgatgtctca ttgaaaaata tcatagcaaa gtgtcttact aaatggggac atgatgttca
      181 tcaaatagaa aatcttgaaa atataataga agagttcaaa aactataacc cagaattagt
      241 tttattggac ataaaccttc cattttatga tggttttcat tggtgtaatg aaataagaaa
      301 aatttcaaaa gttcctataa tttttatttc ttcaagaaat tctaatatgg atgtaataat
      361 gggtgtaaat ttaggtgcag atgattatat acaaaaacct ttttctgtag atgtcttagt
      421 agctaaagtt aatgcccttt taagaagaac ttataatttt gttgataata actcaaatca
      481 gattattcac aatggtgtta ctttagattt atcaactgca acaataaact atgaagataa
      541 tactattgag ctaacaaaaa atgaaatcaa aattctccat gagcttatga aatataaggg
      601 gcagatagta agtaggaata aactcatgaa aaaattatgg gataatgatt ggtttgtaga
      661 tgataataca ttaactgtca atgtaaatag aatacgctca aaattaaatg aaattggttt
      721 agaagatttt atagaaacaa aaagaggatt gggttatata atcagttaaa acaattctaa
      781 gtaggtgaat ttatgagctt taaagatttt ctcaaggata aactaggttt tttagtatac
      841 aattttactt tcttaatttt tacagtatca gttattatat tttctcctgt agatgttttt
      901 ctgactgata ctattttata tatattagtt gtaaatgttg tgtttttatt tttatatcta
      961 tttattagct acatcaagaa gaacaaattt ttagataaga taaaaaatga tacattcaaa
     1021 attaatatga atgatataga attagctaga tgtaaaaatg aagaaaaaat atacttgaac
     1081 attattaaaa atcatcaata tcaatgtaat aacataataa ataataatat cgagaaattt
     1141 gaagaaaaca aagagatttt aaatatgtgg gtacatgatg taaagatacc tatagctata
     1201 ataaaactca ttcttgaaca aaatgaaaat ttaattgatg aaaaaatttc agatgacata
     1261 gatagtgaaa tatttagaat tgaaaactcc gttgaaaaaa ttttatattt atcaagactc
     1321 gaagattttc ataaggattt tttaattcaa gaggtaaata ttgaaaaaat cattagaaat
     1381 attataaaaa aatactcaaa atattttatt tcaaaaaaaa ttattttaga cttaaataat
     1441 ttgaatttta aggttttatc tgatgaaaaa tggctatact tcatattcga gcaattattg
     1501 agtaattccc taaaatactc ctcattagga gataatatat ctatctattg caaaagaacc
     1561 aaaaattatt tacaattaag agtggaagat actggttgtg gtataaaaaa ggaagattta
     1621 aatcgaatat tcaataaggg atttacaggt aataatggaa gaaacaattc taaatctaca
     1681 ggtcttgggc tttatttagt aaaagaactt tgtgataagc ttggtcataa aattgatgta
     1741 gattcagagt acaaccaata tacaaaattt actattacat tcaaatgtga tttatagtat
     1801 cttattattg atagtttatt ttcattaact tatattcaac ttcttatagt aattctatat
     1861 gtacatccca gtatataatt aagtagtttt tataaaaagg aggaagacat gtcttttcta
     1921 aaaaaattta aaaataaaag atttagaaat aacagtttta aaagtaacaa ctttagaaat
     1981 agcagttttg gaagtagtgg cttcaagtct aaaaataaag gttttaaaaa caatcccttt
     2041 aaaaataaga gattcaaaat atatgcagga atagcagtaa tcatactttt aattctagga
     2101 gttcttgctt atgttgattc gaaaaacact gaattacaag ctaatgaaaa ttttatcgaa
     2161 acatatacta ttcctgaaaa tgaaaaaata tttataaatg ggatggttgt tcctaagcaa
     2221 actaaggact tcaatatatc tggagattat gagttaagtg atgttaatgt tacaaatggt
     2281 caaaaagtaa atcaaggaga ccttcttttt actgctaaaa atccaactat aatagcagaa
     2341 atagatagtt taaaatcaca acttagtcaa tacaaaaaac aaaaaatatc actttctgat
     2401 attgctgaaa ataaagatgc tattgcttct ataaatgcac agataactgc tttaaactct
     2461 cagatagctt ctctggataa aaaagcttat gacagagtta ctgctccttt tgatggcaca
     2521 gtatacttga atgaccaaac tggaaatcca gaccaaccag tttcatttat gactattcaa
     2581 ggtctagagt tttatatgaa aggacaagca agtgaacaag atttacctaa aatgaagatt
     2641 gaccaaatgg tcaatatact agttttttca actgaccaaa agcttactgg tagaataagt
     2701 tttatatctg ataaaccatc tactccaaat actgaaatgg gagctcagca gaatacacta
     2761 tcttattatg atataaacat agcatttgat aatcaagaag gattagtaaa tggattccat
     2821 cttcaagcat cacttgaagt agctaattca agctttaaaa taccagcatc ttgtgtactt
     2881 aaagacaaca aacactcata tgtatttaag gatttagatg gtatattgaa aaagcaaatt
     2941 gtagatgtag caagtcaaaa tgatgatttt gctgtagtta gaggcggtct tgaacaaggc
     3001 gatataataa taaaacaccc tactaaagaa atgaaagaag gagacccagt tcaaggcgat
     3061 ggcgtaactg ctggttctaa taatggagat actactccaa acaaaaaagt agaagaagtt
     3121 actatggatg tgaattaatt tacatatgtt aattaaatta gaaaatattc aaaaatatta
     3181 caaagtaggg aaagatgaat tacatgtttt aaaatcctta aatttagaaa ttgaatctgg
     3241 agaatttgtc atgataatgg gtaagtctgg tagtggtaaa actactttac ttaatatctt
     3301 aggttttcta gatgtatttg atgaaggaag atatatattt gatggaacag atgtaactaa
     3361 tttgagtgaa aatgaacgtt ctgtttttag aaatattaat attggatttg ttttccaaca
     3421 atttaattta atagaaactc taaatgtata tcaaaatgta gagttgcctc taatttacaa
     3481 taaagcacta aaaaaatcta atagagaaga aattgttaaa gataaattaa gttctgttgg
     3541 gcttttggac aagcttaagc agaaaccact tcaattatct ggtggtcaac aacagcgtgt
     3601 agccattgca cgttgcctag caaatgaccc tcagataatc tttgctgatg aaccgactgg
     3661 ggcattagat agtgaaacta gcagagaaat tatggagctt ttaacaaggc tcaacaaaca
     3721 aggtaagact ataataatgg ttacacatga tcaagattta actaagtatg caactaaggt
     3781 tatacgactt aaagatggtg tgtttacttc ggaggtgtaa tcatgagttt attaaaaaat
     3841 tctttggcca atttaaaagg tcacaagctt cgtgtatttg tagctttact ctggattata
     3901 ataggaataa cttcagtaat acttgttagt tctataggta atggatttca aaaagaaatt
     3961 aagaaatctg taaacaatgt aaaccctaat aaaactacta tttcgtttga atcagccgat
     4021 aacacaggtc ttactgatga tatgagtatt tttttaaaac cctttaatgc aaaagattta
     4081 gaagaattat catttgttga aggagtagaa agaatagctc cttcaagaga tgggtttaac
     4141 cttgattcag tttactcttc acaagcatct tttgataaaa aaactacgta tgttgatgtt
     4201 ggaccagtaa aaaaagattc taaaataaat ttaatttgtg gtagagattt ttctttagat
     4261 gatgaaaaaa gaaaagtaat tttacttaca ttacaaagta caagtgaaat ttttgaaaat
     4321 ccagaagatg ccttaggtca tggtatcaac ataaatggaa ctatatttga aataataggg
     4381 gtattagatg attctcagca aaaccaagct ggaggattct ttggaggtta ccaagatatg
     4441 caatttacta cttccctagt acctaaaaag gcttttgaca ctttaatgag tcaaaattct
     4501 tattcaaatg aaatttacca gttagactta gtttcttcta aaggctataa tgtaaatgaa
     4561 gttgcaaaca atgttatagc taaattatat gagatgcacc ctggtatcaa tggttcttat
     4621 actacaccag acccaactga acagacagct tatcttgaaa gcattaattc caatgtaaac
     4681 aaatatgtat ctataataac tgtagttgca atgtttgttg gtggtattgg tgtaatgaat
     4741 ataatgtatg tatctgttat ggaaagacaa agagaaattg gtataagacg tgctattgga
     4801 gcaaaaccta ggtctatatt atttcaattt ttagttgaag ctgtttttat aacagtatgt
     4861 ggtggaattt taggaactat agttggattt gctgctacta actatgtttc taaatatata
     4921 ggttttgaag ctatacctag cttaaatagc ttattttatg caattgtagc tactatattg
     4981 actggagttg tatttggtct gattccagcc tttaaagcct ctaaactaga ccctataaag
     5041 gcaatttata agtagaaatt gtataaagat tttcgatttt tagattagtt tatataaaac
     5101 atacttaaat atataacgca ctattatata tgatagatta ggaacttaat ctttccaaat
     5161 ataatagtgc gttctttcat aaaaaggatt ctcttcctta ctatatctaa attaccaaga
     5221 tgttatgttc taattgttca aactaatact tccaattttg attaatcaat ctcattctcc
     5281 taatatacaa tcttttactt tcaatcattg tacactccgc cttaaaaaaa taatcttaaa
     5341 ttatgcgtta tatacaatct ccccattaca tattgtataa ttaacctttc catataaaga
     5401 tttaccttta aatggtgaat tatcagcttt agaaacaaag ctttcaactg tccattcttc
     5461 ttctggattg aatataacaa tgtctgctac agccccttct tctataaatc caatatttaa
     5521 attgtacaac tttgcaggat ttatagacat tttttctatt aactgcatca tactaagatg
     5581 atttttatgc accaaatttg ttattccaag agctaaagaa gtttcaagcc caataattcc
     5641 acttggagct tttataaact ctctatcttt ttcttcttta ctatgaggtg catggtccgt
     5701 tgctattatt tcaatagtac catcatttaa tccctctata atcttatctc tgtcccattt
     5761 acttcttaga ggtggattca tttttgcatt tgttccaaac tccaatacat cttcctcagt
     5821 caatgtaaag tgatgtggtg aagcttctgc aactacattt gcacctaagt attttgcaaa
     5881 tctaaccata tcaacagata cacctgaact tatatgttgt atatcaactt tagcaccagt
     5941 ctttagtgcc aacatacaat ctctggctac cataacatct tctgctacac ttgatgcacc
     6001 ttttaatcct agttctgaag ctacctttcc tgcatttaca cctggatttc caactaaaga
     6061 agggtcttct tcatgaaaac taagtggtac atccaactct tttgccttaa tcattgcctc
     6121 cataattaga ttgctatcca ttaaaggtaa tccatcatca gtaaaccctg gtacaccagc
     6181 ttttttaaga gcttccatat caactaactc tttaccttca aaacctttag ttatagctgc
     6241 tgcttgtaaa acatttatac atgcattttt tgacttttct ttaacataat taaaagtatc
     6301 ttcattatct acaataggat tagtatttgc catacatata acagttgtaa atccacctct
     6361 agcagcagat ttagctccac tttctatatc ttctttatat gtaaacccag ggtctctaaa
     6421 gtgtacatgt acatccacta aacctggagc aactacatta ccactagcat ctattatttt
     6481 ttcatattca tcactttcat caaacttgcc tattttataa attttatttt cttttataat
     6541 taagtcaata ttctcatctc tttgactttt agggtctatt actctaccat ttttaattaa
     6601 aatcatatta tttctccttt atatttttaa tttatataga ctcatataat attatacatt
     6661 attttacata cttaaataca aaattacgtt tgacatcaat agccttttta ggacaaagtt
     6721 catggcaaca gtaacatctt atacatttac ttaagtctat aatagcaccc ttagtcccta
     6781 tctctatagt ggatgcagga caagcttcct tgcattttcc acattttatg caatcttgaa
     6841 atcttaccac aggctttggt gttataagct ttgaaatagg ttcatttaaa aattttggta
     6901 gctttacaga aaacaatctt aaatccttac ttacatttgg aatcttgtaa ttttttataa
     6961 ttaaatcttt tatatcttca cctaaaattt caatatctga aaaatcttct tgtatatatc
     7021 ctctcttaat agcacctcta attgtagcaa ctctatttgg aagtaaactt ataatcttac
     7081 atgcaacaac atctatagca tatggatttt gtgatgctaa taaaactcct atttctcgag
     7141 tagtaccagc tgaaggtcca tcaccttcca tacctactat accatccata attgtcaatg
     7201 ttggttttat ataatcacaa atatctaaaa gtacattttc gcaaaacaac tcttctgtag
     7261 gaaatctata atgtatctct gcttttttca atccagctat gcatccatat aagttttttg
     7321 taccaccagt aaaagttgcc attatatgag tctttaattt acaaagattt attatataat
     7381 ctgaatctac tattggttta ataatatcca tatattttag aacatgtgct ttttcactat
     7441 gtatcttaac atctgaaaca tcataattta acttaatgcc cagttcattt gctacttctt
     7501 caattccaga tgccttataa atgctcttaa gagaactttg attatatgga ccaccagggc
     7561 tatctgctat tgtaatatca caatttaact ctaaaagttt ttcacataca acttttacaa
     7621 ccataggatg tgtagttgta gcttcttcag gctttttttt cattaataaa tttggtttta
     7681 taagtacttt gcttcctttt ttaacaaact tatctatacc accaatatcc tctaaatttt
     7741 tttcaataga taactttact tcttcataat tgtaagtttt acaactccta acagataccg
     7801 acttcatatt atctccatcc ttctatcaca acagtttatt tgtataattt aaaaaaggag
     7861 aaaccaaagt ttctcctttt aatctatgtt ttaattgttt taattattat tttccaaaat
     7921 gtctgtttaa taatcctaag aatgctttac catgtctagc ttcgtcttta cacatttcat
     7981 gtactgtatc atgtatagca tctaatccta attctttagc t
//
LOCUS       DAEQCW010000136         7910 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.137, whole genome shotgun sequence.
ACCESSION   DAEQCW010000136 DAEQCW010000000
VERSION     DAEQCW010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7910)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7910)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7910
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.137"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            257..1021
                     /locus_tag="KRO40_003207"
     CDS             257..1021
                     /locus_tag="KRO40_003207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH2094005.1"
                     /translation="MLPQERYEKILSILKSDNIIKINDIVQMFDISIETARRDLAHME
                     SIGLLKRVYGGAIPVIASSVELNYVKRKKINSNDKKQIAIKCSEFINTNDTIFMDTGT
                     TVLEVSKNLKDKKNLTVITNSILVANELMNTNIKVYVLGGYLRETEGSFSGPLTLSAI
                     EQFNVDKAILGAGGITLENGISDYHLEEALVRKKMIERSRKSIVVVEPPKFGINSFAS
                     VAPIEHIDTIITSASIDHNIIIEFSQKGIPLVIADN"
     gene            complement(1302..2417)
                     /locus_tag="KRO40_003208"
     CDS             complement(1302..2417)
                     /locus_tag="KRO40_003208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBH2094006.1"
                     /translation="MPFDKIILYIMAVGVLLGALDRIIGNKFGLGEQFEEGFNSMGPL
                     ALGMVGIVCLAPVISDVLGPIIIPIFNLCGADPSMFATILANDMGGYPLAMELAHNKE
                     AGMLAGLVVSSMLGCTLVFSIPVGLGLIEYEDRPFFAKGLLIGLITIPFGGIIGGLIA
                     GFNLSMVIINMIPVIILAVILAVGLKFNSTLMINGSLIFGKFISILITIGLGAAAFQE
                     ITGIVLIKGMTPIREGIQVIGSIAIVLLGTFPILHLLVKVLNKPLTIVGGKLGMDATS
                     AAGLVFTLANSIPVYKMMKDMSPKGKVVNTAWLVCATAALGDHLGFTAGVVPEMITPV
                     VIGKLVGGVLAIALAILMTKDLTLEEEQSIKMKKDAV"
     gene            complement(2458..3984)
                     /gene="glpK"
                     /locus_tag="KRO40_003209"
     CDS             complement(2458..3984)
                     /gene="glpK"
                     /locus_tag="KRO40_003209"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBH2094007.1"
                     /translation="MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVE
                     HDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGIDNQGETVMLWDKNTGKPLYNAI
                     VWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
                     EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGIPRSILAD
                     IMPTSGDFGTTDKEAFCGVSIKITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMN
                     IGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRDGIGVIKNYSETDDM
                     ANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKD
                     VVDSMNLASGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAG
                     LSCGVWNSIDEIRSEFTISKKYIPNMTNQKREEILLGWNQAVKRAMNWENDTKKVCAN
                     "
     gene            4277..5374
                     /locus_tag="KRO40_003210"
     CDS             4277..5374
                     /locus_tag="KRO40_003210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBH2094008.1"
                     /translation="MKKTYLFSPGPVMVTDKVRNSLLHYDICHRGNEFMNLFKDTQQK
                     INKLYNATSNYYSLIVSGSGTSVNECVLSSIFDKEDAVLLVSNGVFGERLEEILSTYN
                     VKTYKPNFEWAEYPDLDILEKYIIENSDIKVIAMVFHETSSGMINPVPELGKLAKKYN
                     KIFFVDAISASAGEYIDVEEFNIDIITGVGGKALGAFPGSAYLCAKESILQNIKENQC
                     KNVYLNLYKHYKVAKSSSQTPNTPNVTLIFALNEALTEFLEDDSKIERYKECSAILRN
                     GMEELGLTFLLPDKYMSNTVTSVFLPKEINVNEFILGLERESGYVVYPGKGKFLDANI
                     FQVANMGEIYPDDCYKFLDILKSKLEIKKVI"
     gene            complement(5865..6377)
                     /locus_tag="KRO40_003211"
     CDS             complement(5865..6377)
                     /locus_tag="KRO40_003211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094009.1"
                     /translation="MKVKKFKSGIVMALTVMAIGASLTNVSAMELNKSKEFETKYNEM
                     KRDFQEEYGKEDKFNITLDDEFTKEEVNGAKGIIKTTNKMNNEVVVLNYFDEMKSGIE
                     FELKPKAEKNAILRDEFQQGYGKEDKFKVVLDDEFTKEEVNGAKGIIKTTDKETGEVI
                     VYNYFDELEK"
     gene            6930..7811
                     /locus_tag="KRO40_003212"
     CDS             6930..7811
                     /locus_tag="KRO40_003212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HBH2094010.1"
                     /translation="MKKRLIIMILSVVLVLSSILTIFAYSNIKYNNNKLIYSNMIDKK
                     TQNSVKEILKENKINEKDIDTFIKAVNNYNKLQVKILQNNINISKSGYSSINAKQVPY
                     NLEKLQDNWVKKFPDYMDVNCRITAFRLFKDFINSNKKFTGDSIDLNVDLDTIMNNKD
                     AKFSTKDVEKFINFFSAIPAKDTDDTIKIAEQIKNEWKKRKISFKNNKNISIINGFLR
                     YPETKNVFIGHTGICIKTKNGILFLEKYGVTSPYQVTKFKNKEDVKNYMFNRLKMSEG
                     EIELPDPIIMENDKLMK"
BASE COUNT         2771 a         1270 c          921 g         2948 t
ORIGIN      
        1 atctctatac tagtaaatta tataataaaa tcatatttta gtcaattgtt ttataaaatt
       61 tgagttattt tgaattatta aacatctatt tttacttttt tgcttaaatg taagttttaa
      121 atatggtaaa attatcttgc ataacactta taatattatt tgataaatat acatacatta
      181 acaaatatac ctaaactctg acttaattgt aagttatgcc aaaactaaaa taatactagt
      241 ccaaggagga tattttatgt taccacagga aagatatgag aagattttaa gtattctcaa
      301 atcagataat ataattaaaa taaatgacat agttcaaatg tttgatatat caatagaaac
      361 tgcacgaaga gatttagccc atatggagag tatcggtctt ttaaaaagag tttatggtgg
      421 tgctatacca gttatagcaa gtagcgtaga acttaactat gttaaaagaa aaaaaataaa
      481 ctcaaacgat aaaaaacaga ttgctattaa atgtagtgag tttataaata caaatgatac
      541 tatttttatg gatactggaa ctactgtact tgaagtttca aaaaatttga aagataaaaa
      601 gaatctaact gtaataacca actcaatttt agttgcaaac gaacttatga atactaatat
      661 aaaagtatat gtgcttgggg gctatcttag agaaactgaa ggttcttttt ctggtccgct
      721 tacactgtca gctattgaac aatttaatgt tgataaagct attttaggcg ctggaggtat
      781 cactcttgaa aatggaatct ctgactatca cttagaagaa gcacttgtta gaaaaaaaat
      841 gattgaaagg tctagaaaat ctatagtagt tgtcgaacct cctaagtttg gtataaattc
      901 atttgcatca gtagctccta tagaacatat agatactatt attacctctg ctagtataga
      961 ccataatata ataatagagt tttctcaaaa aggaatacct ttagtcatag ctgataatta
     1021 gcttatatga ttgattttta gttccttgat gtaataaatt aaaattaagg agccaaataa
     1081 ttatttattt agctccattt atgtctaaac tatactttat attttaatta tgtaactact
     1141 ttcagttagc ttatcatttt tagttatttg attgccattt tatttaattt ataagtttta
     1201 gttattcgat tattttttaa ttgtctgtct ttttaattta tttttagtta tttaaactcc
     1261 tactttaaaa taatttaaat ttgacttaag tattgtttat tctacactgc atctttcttc
     1321 attttaatac tttgttcttc ttccaaggtt aaatcttttg tcataagtat agcaagtgca
     1381 attgccaata ctcctccaac caattttcca attacaacag gtgtaatcat ctctggaact
     1441 actcctgctg taaatcctaa atggtccccc aaagctgctg tagcacaaac cagccaagca
     1501 gtatttacta ctttcccctt tggactcata tctttcatca ttttatatac tggaatacta
     1561 ttggctaaag taaaaactaa tcctgctgca ctagtggcat ccatacctaa ttttccaccc
     1621 actattgtaa gtggtttatt aagaacttta actaataaat gtaatattgg aaaagtacct
     1681 aataacacga ttgcaatact tccaattact tgaatacctt ctcttatagg tgtcatgcct
     1741 tttataagta ctatacctgt tatttcttga aatgctgctg ctcccaaacc tatcgttatc
     1801 aatatagata taaattttcc aaaaattaat gacccattta tcataagcgt agaattaaat
     1861 tttaaaccta ctgccaatat cactgccaat attatcactg gtatcatatt tataattacc
     1921 attgataagt taaatcctgc tattaatcct cctataatac ctccaaaagg tattgttatc
     1981 aagcctatca gtaacccttt tgcaaagaat ggtctgtctt catattctat aagacctagt
     2041 cctactggaa ttgaaaatac taatgtacat ccaagcatgg atgacacaac caatcctgca
     2101 agcattcctg cctctttatt gtgtgcaagt tccatagcca atggataccc tcccatatca
     2161 ttcgctaaaa tagttgcaaa catagatggg tcagctccac agagattgaa gattggtatt
     2221 attataggac ctagtacatc tgaaattact ggagctaaac aaactatacc aaccattcct
     2281 aaagccaatg gacccattga attaaaccct tcttcaaact gctctccaag tccaaattta
     2341 tttccaatta ttctatctaa cgctcctaaa agcactccca cagccattat gtataatata
     2401 attttatcaa agggcatttt taattcctcc tatacatgta aaatactcta ttgtaactta
     2461 attagcacac acctttttgg tatcgttttc ccaattcata gctcttttta ctgcttgatt
     2521 ccatccaagt aatatttctt ctcttttttg attagtcata tttggaatat attttttgct
     2581 tattgtaaat tcacttctaa tttcatcaat actgttccag acaccacaag aaagacctgc
     2641 catatatcct actccaagta ctgtcgtctc aggattttct gcaatttcaa ttggtatacc
     2701 taatatgtcg gattgaaatt gcattgtaaa gttattttta gtaattccac catctactct
     2761 caacattttt atttttttcc ctgaggctaa gttcatagaa tcaacaacat ctttgacttg
     2821 aagtgcaaca gactcaagag tcgctcttac tatatgctct tttttagtac ttcctgttat
     2881 cccaaccatt gtacctctag catattggtc ccaataaggt gctgctatac ctgcaaatgc
     2941 tggtacaaaa tatacacctc cagtacttga tatggaattt gccatgtcat cagtttctga
     3001 ataatttttt ataactccaa tgccatctct aagccattgt attgcagcac ctgctatata
     3061 cactccacca tcataagcat atgtaacttt atctcctatt ttccaagcaa cagttgtcaa
     3121 aataccatta cctgctatat ttagttcctc acctatattc atatatagga aacatcctgt
     3181 accataagta tttttaacca ttcctggttc aaaacatcca ttgccaaata aagctgctgg
     3241 ttggtctacc attgaagcag taatttttat agaaacccca caaaatgcct ccttatctgt
     3301 agttccaaaa tcaccactcg taggcattat atctgctaaa atacttctag gtattcctat
     3361 aatgtcaagc aactctctat cccaatccat atctcttata ttaaaaagca ttgttcttgc
     3421 tgctgtagat acatcagtta aaaaagattt tcctcctgtc attttccata ttaaccaact
     3481 atctaatgtt cctgcaagta cttctccatt tttaattttt tcttttacac cttttacatt
     3541 atctattacc catttaattt ttgtacctga gaaatatggg tctataatta acccagtctt
     3601 atctattatc ttattttcta aacctggtat attctttaaa ttttccacat aatcataagt
     3661 tctcctgcac tgccacacaa tagcattgta aagtggttta cctgtatttt tatcccataa
     3721 cattactgtt tcaccttgat tatctatacc aattcctttt atatcacttt cattgattcc
     3781 attttcaaaa gcctgttgta atacattatt actcacagtt tttgtattat tccaaatttc
     3841 tatagggtca tgttcaacat atccagattg tggatatatt tgagtatgtt ccatataatc
     3901 gctaaaaaca aactctgatt tttcgtttat caatactgct cttgttcctg ttgttccttg
     3961 gtcaattgct aatacatatt tcactttaaa tgtccccctt tattttcaga attaacaaat
     4021 tcttttttat tttttgaata tataatctat tcaagttatt tatattttat atcatcatgt
     4081 ggatttatgc aatattcatt acaatatttt ttgttatttt taattatagt gattaaaaaa
     4141 gtatttttat tgaaatatta ttgcaatatt tattatttta ttctataatc tagttaaaat
     4201 aacacataac attttaatat ttacacataa tcagtcattc aaaaatttaa atttaacttt
     4261 ttaaggaggc tttacaatga aaaaaacata tctattcagt cctggaccag taatggttac
     4321 agataaagtc agaaattcac ttcttcacta tgatatatgc catagaggaa atgagtttat
     4381 gaatttattc aaagatacac aacaaaaaat caataaacta tataatgcaa cttctaatta
     4441 ctactcatta attgtatctg gctctggaac atctgtaaat gaatgtgtac tatcttctat
     4501 ctttgacaaa gaagatgcag ttctgctagt tagtaatggt gtttttggag aaaggctaga
     4561 agaaatatta tctacttata atgtaaaaac atataaacct aattttgaat gggcagaata
     4621 cccggaccta gatattttag aaaaatacat aattgaaaat tctgatataa aagtaattgc
     4681 tatggtgttc catgaaacta gttcaggaat gataaatccc gtccctgaac taggaaaact
     4741 tgctaagaag tataacaaaa tattttttgt agatgcaata agtgcctcag caggtgaata
     4801 tattgatgtg gaagagttta atatagatat aataacaggt gttggtggca aagctcttgg
     4861 agcatttcca ggttctgcat acctttgtgc taaagagagt attttacaaa atattaaaga
     4921 aaatcaatgt aagaatgtgt atcttaatct ttataaacac tataaagttg ctaaatcatc
     4981 ttctcaaaca ccaaatacac ctaatgttac tttaatattt gcccttaatg aagctttaac
     5041 tgaatttttg gaagatgaca gtaaaataga aagatacaaa gaatgttctg ctattttaag
     5101 gaacggtatg gaagaattgg gtctaacatt tttacttcca gataagtata tgtctaatac
     5161 agtaacatct gtatttctac ctaaagaaat caatgtaaat gagtttatat tagggctaga
     5221 aagggaaagt ggctatgttg tctatccagg aaaaggcaaa ttcctagatg ctaacatatt
     5281 ccaagtagca aatatgggag aaatatatcc agacgattgt tataaattct tagatatctt
     5341 aaaatcaaaa ttggagataa aaaaagttat ataacagttt gtttgtaaaa tcctacaata
     5401 tatcagtata aattaaatag actgattttt ttaaattttc ctataataaa ttatatttta
     5461 tatttttgta taagggtgaa ctataatatg taaagttcac ccctatttca aatctttttc
     5521 cttcaatata atctttttct tttaatttat tttatatttt tgacgcaatc gttttttatt
     5581 caatcatttt atattcttga tacaatcatt cttacactta attatttttt gtttttgaca
     5641 caatcgtttt ttgttgaatc attttatatt cttgatacaa tcattcttac acttaattat
     5701 tttttgtttt tgacacaatc gttttttatt cagtcattta atattttcaa cacaatcatt
     5761 cttacattct attattgttt gtttttgata caactgtttt tattcagtca tttaatattc
     5821 tcaacacaat taccttttca ttcaatcaaa gtaatcttta agcattattt ttcaagctca
     5881 tcaaagtaat tatatacgat aacctcacct gtctctttat ctgtagtctt tataatgccc
     5941 ttagctccat ttacctcttc ttttgtaaat tcatcatcta acacaacttt gaatttatct
     6001 tcctttccat aaccttgttg aaattcatct ctcaaaattg catttttttc tgcttttggc
     6061 ttcaactcaa attcaattcc agatttcatt tcatcaaaat aatttaatac tacaacctca
     6121 ttattcattt tattagttgt ctttataatc cctttagctc catttacttc ttcttttgta
     6181 aattcatcat ccaatgttat attaaatttg tcttcttttc catattcctc ttgaaaatcc
     6241 ctcttcattt cattgtattt agtttcaaac tctttactct tgtttaattc catagctgat
     6301 acatttgtca atgatgctcc aattgccatt actgttaatg ccattactat accactttta
     6361 aattttttta ctttcatatc ttacctccta aattaaatgt tctcaatgaa attatataaa
     6421 gaaaatccta agttttacag tttcattctt gtaactaaaa ttactattat gtaaccaaac
     6481 tttttgcttc aactattcct taaaagttgc ttttttgagg aatagttgaa gttaaataat
     6541 tagattttat ctatatttat agatttaaaa tcaaatttat ccatataaat aaatacttat
     6601 ttttgcaaaa taaaaatttt taattactcc aatccttctt atttacttaa aattctatga
     6661 taagaaattt aaaagtcttt accttcttta acaataattt atttactttt aacatacaaa
     6721 atagagagag tatatcaaaa tcattttact gaatattcta aaaataagta ccccctatta
     6781 gtatatatat ttacatatta aaaaaaagtt ttaaataaag ttatattttt tacaacagtt
     6841 ttgtaattaa aaacatattg aaggtaaatt taaaggtact atatactata aatatgtcga
     6901 cacaataaat ttaaaaagga gaactaaata tgaaaaaaag attaataata atgatattgt
     6961 ctgttgtctt agtactatca agtatactta cgatatttgc atattcaaat attaaatata
     7021 ataataacaa attgatatat tctaatatga tagataaaaa aactcaaaat agtgtaaagg
     7081 aaatcctaaa agaaaataaa attaatgaaa aagacataga tacatttatt aaagcagtca
     7141 acaattataa taaattgcaa gttaaaatac ttcaaaataa tataaatata tctaaatctg
     7201 gatattcttc aatcaatgca aaacaagttc catataacct agaaaaattg caagataatt
     7261 gggtgaaaaa attccctgat tatatggatg taaattgtag aataactgct tttagacttt
     7321 ttaaagattt tataaattca aataagaaat ttactggaga ctctattgat ttgaatgtcg
     7381 acttggacac tataatgaat aataaagatg ctaaatttag caccaaagat gtagaaaaat
     7441 ttattaactt cttttctgca ataccagcta aagacacaga tgatacaatc aaaattgcag
     7501 aacaaataaa aaatgaatgg aaaaaaagaa aaatatcttt taaaaataat aaaaatatat
     7561 ctattataaa tggatttctt cgttatccag aaactaaaaa cgtatttata ggtcatacag
     7621 gcatatgtat taaaactaaa aatggcattc tatttttaga aaaatatggt gttacatcac
     7681 cttatcaagt tactaaattt aaaaataaag aagatgtaaa aaattatatg tttaatagat
     7741 tgaagatgtc agaaggtgaa attgaattac ctgaccctat aataatggaa aacgataaac
     7801 ttatgaaata ataactttaa acgcaaaata gtatttataa ttactaagtc aatataatag
     7861 agaaggtcta tagatttgtg taaatacaag cttatctaca atcttatata
//
LOCUS       DAEQCW010000137         7904 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.138, whole genome shotgun sequence.
ACCESSION   DAEQCW010000137 DAEQCW010000000
VERSION     DAEQCW010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7904)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7904)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7904
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.138"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     misc_binding    150..361
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            524..1813
                     /locus_tag="KRO40_003213"
     CDS             524..1813
                     /locus_tag="KRO40_003213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBH2094011.1"
                     /translation="MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAEL
                     AQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSLSTSMITKYVFGEAGAKIFSLVI
                     GVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
                     SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDI
                     SRWAKSRRDCALSSFLGIQFGNAFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVL
                     TLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAVFGIYEGFIGFLNLL
                     GIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFIT
                     LTTIAPLDGFIAGFVVQSIIGKVLCSTKNKQEIDKAV"
     gene            1867..2946
                     /locus_tag="KRO40_003214"
     CDS             1867..2946
                     /locus_tag="KRO40_003214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF917 domain-containing protein"
                     /protein_id="HBH2094012.1"
                     /translation="MRFLTEESVDKIAVGAAVLGTGGGGDPYVGKLVAKQAIKKYGPV
                     KVISLDELDDDALVVPVSGMGSPVITIEKLLSEVELTTPLEIMEKLLNRKVDVIIPIE
                     IGGINSLMPIAVAAKKGLPILDADSMGRAFPEAQMVTFYLEGYEASPAVMSDEKGNSA
                     ILYPVDGIWSERLARTLTVEMGGSSSISDYNLSGAQVKKAAIGNTLTIAETIGGFLLE
                     NKSDSKGAVENILKELCGYKLFEGKVIDIKRELKGGFTRGHAFFAGINEYDGEYSILF
                     QNENLIAKKGDTPLCITPDLIAVLDLETGFPITTERIKYGSRVMVVAFPCNEKWRTEK
                     GIETVGPGYFGYDVEYKTVEELQGK"
     gene            2967..4511
                     /locus_tag="KRO40_003215"
     CDS             2967..4511
                     /locus_tag="KRO40_003215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020246462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="HBH2094013.1"
                     /translation="MYRVGIDVGGTNTDACILDGELKVIHSVKVATTKDVETGVYNAL
                     KKVIDESKIDHSLIKYAMLGTTHCTNAIVERKRLNNVAMIRIGKPATTAILPFIDWPE
                     DLREKIELDSILVSGGYEFDGRKINELCKDEVVEFCNRIKGKVESVAISGVFAPVNKQ
                     QEEEVAKWVREILGDIPISLSNEIGNIGILERENGAILNSALSQVGKAVSLGFEKALK
                     DLGIDAQIYFSQNDGTLMNLEYTMKYPIFTIGCGITNSIRGASFLSKVKNAIVLDVGG
                     TTSDLGVLYNGFPRESSIPVTIGGVHTNFRMPDVLTIGLAGGTCVKGEKDNIKIGPES
                     VGYRITEDAIIFGGDTLTLSDVVTKLDMAFEDRKSNVENLDKEYCNEVYKKVILKLED
                     AVDQMKTSQDDVELVLTGGGSIIVPEKLKGISNVIRPPHYTAANAIGAALGQISGDVE
                     KVYSLDKMSREDAIEDAKKEAVNKALKAGAKEDTIEVLNIEDVPLAYLPGNALLIKVK
                     VVGDLI"
     gene            complement(4674..5216)
                     /locus_tag="KRO40_003216"
     CDS             complement(4674..5216)
                     /locus_tag="KRO40_003216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HBH2094014.1"
                     /translation="MKSYIALLRGINISGKNKIIMSELKASFVELGYSEVSTYLNSGN
                     VVFLSDVDDSKVISNTIRLMIKKQFELEIPVFIISQEELKDILNNAPNWWGDNNKEIY
                     DNLIFMFPDLSYDEFYDEVGNPKEEYEKVYHYKNAIFWSFSRKDYKKTNWWSKTASSN
                     VSDKITIRTANTVRKIVGMR"
     gene            complement(5364..5648)
                     /locus_tag="KRO40_003217"
     CDS             complement(5364..5648)
                     /locus_tag="KRO40_003217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH2094015.1"
                     /translation="MAKNTKQTTVHIDETLLKEVKRIGINENKSISQIINESIIDYIL
                     VYRENEDKEKNEHDKNLNETINEFKKEEEKRMQAKSAARAIAEAKKRVLY"
     gene            complement(5711..6475)
                     /locus_tag="KRO40_003218"
     CDS             complement(5711..6475)
                     /locus_tag="KRO40_003218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBH2094016.1"
                     /translation="MNNYLKFATYQLIGFTSSIPRLIKIKKNPDKFSLKEKFEFMQKQ
                     AKKSLDIVNIELNIIGKETLPKEPLLFVVNHSSMLDSFILTASVERPIGCVIADEPVW
                     RNIPIFKEWAKLLRCVYVNRKNNREGIKSIAQASQNILTGQSMAVFPEGDLTWIKEPN
                     SLVSEFRSGALKIAYKAKCPIVPLVIKNSKDTYEGYQPIGKINSVPVEVEFLEPIYDH
                     IENPRLKSSVLGENIKNKMINTIENFRKSNKTFKEF"
     gene            complement(6757..7023)
                     /locus_tag="KRO40_003219"
     CDS             complement(6757..7023)
                     /locus_tag="KRO40_003219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH2094017.1"
                     /translation="MIESRCGILCYECGYKEKVNCKGCTEIEKPFWGEQCPVKSCCED
                     KNLTHCGLCDTFPCEMLNQFAYDKEQGDDGKRISQCKKWAVLAL"
     gene            complement(7065..7874)
                     /locus_tag="KRO40_003220"
     CDS             complement(7065..7874)
                     /locus_tag="KRO40_003220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094018.1"
                     /translation="MNKIINNILNTCKQYTYILPHKLLRQYIAHYTISIPDTSIKENL
                     TLIPDASGCMIFKFDKKGIESAFWGATTKTTIVKNDIENVLFRVFVEFRPGGVYYLTG
                     LSQRESTDLKISLEDFNTLFSLEVNSIFERTSTIKELVEQLDMLFLSYLLKSNIVDMT
                     IPILENARKQNSIMSVKNISQISCYSERHLNRIFNNSLGMSVKSYLRLLRINLVLQEI
                     QNNKIPFATLAQDIGYYDQSHFINDFKSICGVNPTTYIKNLSDFYNEKYKF"
BASE COUNT         2765 a         1000 c         1286 g         2853 t
ORIGIN      
        1 gaaatttaaa aaaatacatt atataaatat agtaatagta tgaaaattta catataaaac
       61 taaaaaatgc aagtaattga ctttttaagt tgacaaaata ttgcatatat attatgatat
      121 aaatcataaa ttaactacaa atcaatatta tatattcgta gaagaagaaa gtagcataaa
      181 ggaattttac agagagttag atttggctga gaactaatat tggaatttat gtgaaaagga
      241 ctttggagaa tactattgta attatgttag aatagtggtt taattcgcct taagaaaatg
      301 agtgagtaaa attaattttt actaataaga gtggtaacac ggatttatat tcgtctcttg
      361 gatttttcca agaggcgttt tttattataa acttatttca gaaaatttaa aactatatat
      421 taaatgaaaa ttataaaaat atgatagtta ataaatttat aaattagaaa attgtaaaat
      481 atgctaaggt cagtagtttt acgatttaaa tggagggatg aaaatggaag aagaaaaaat
      541 taactatgct ctggaacaga ttccagagaa tcaaaaacgt ggttgggtag ctatgttttc
      601 agttttagta gcaataggtg tggatttatc atctgttatt ttaggcgctg agttggcaca
      661 gagtatgcca atgaaacaag caatattgtc agtaattgtt ggttcatttt tttctgcaat
      721 tttgtatact acatgctctt tggttggttc atctacaagt ttatctacat ctatgataac
      781 aaagtatgta tttggagaag ctggagcaaa aatattttct ctagttatag gggtttctct
      841 attaggttgg tttggagttc aagtaggttt ctttgctcaa aatgcacaga taataataaa
      901 agatatattt aatttagatg tcagtatgca gattttaagc ctaataggtg gtctcttgat
      961 gatgagtact gcaatttatg gatataaggc aatggagaag ttgagtgtgt attcagtacc
     1021 atttttatta gttcttatga tgctaactat attcttagct tttagagcaa atggaatttc
     1081 agttgatgat aatatgaaat ctactatgac atttgcaggt ggagtttctc tgtcaatgag
     1141 tataataata gttggtgcaa ttgtatctcc tgatataagt cgttgggcta aaagtagaag
     1201 agactgtgct ctttcaagct ttttgggaat acaatttgga aatgctttta tgataatagt
     1261 ttcgatagta ttagtaaaat gtatgggaac ttcagatatt atgagaattt ttattacatt
     1321 aggaattgct ataccaggta taatagtact tacattagca caatggacta caaatacaag
     1381 taatgtatat tcagcatcat taagtatagc tcttgtactt aagaaggctc ctgagaaagt
     1441 attaactata gtccttggta ttatagcaac attattggct gtatttggaa tatatgaagg
     1501 ttttatagga tttttaaatt tacttggaat tgtaattgca cctgttggtg gtgtatatac
     1561 agcagaatat tacatagtaa agcaagaact taaaggcttt gataaaggag tattatataa
     1621 accaatagtt aaacgttcaa tagtgtcttg gataattggt atattaataa cttacctttc
     1681 aacatatgga tttataactc ttactactat agcaccttta gatggtttta tagcagggtt
     1741 tgtagtacaa tctattattg gaaaagtgct ttgttcaaca aaaaataagc aagaaataga
     1801 caaagcagta taaagaaatt tgtttataaa gtataaaata aattagaaat atgaggagaa
     1861 agtaacatga gatttttaac agaagaaagt gtagataaaa tagcagttgg tgcagcagtg
     1921 cttggaactg gaggtggagg tgacccatat gtaggtaaat tggttgcaaa acaagccatt
     1981 aaaaagtatg gtcctgtaaa agtaataagt ttagatgaac ttgatgatga tgctttggta
     2041 gttccagtat ctggtatggg ttctcctgta attacaatag aaaaattact ttcagaagta
     2101 gagttaacta cccctttaga aataatggag aaattattaa atagaaaagt ggatgttata
     2161 attcctatag aaataggagg gataaactca cttatgccta tagcagttgc tgctaaaaaa
     2221 ggacttccta tcttagatgc agattctatg ggtagagctt tccctgaagc tcaaatggta
     2281 actttttatc ttgaaggata tgaggcatct cctgccgtaa tgtctgatga aaaaggtaat
     2341 tctgccatcc tttatcctgt ggatggaatt tggtcagaaa gattagctag aactttaact
     2401 gtagaaatgg gaggaagttc ttctattagt gactataatt taagtggagc tcaagttaaa
     2461 aaagctgcta taggtaatac tcttacaata gctgaaacta taggagggtt tttacttgaa
     2521 aataaatctg attcaaaagg tgctgttgag aatatactaa aagaattgtg tggatacaag
     2581 ttatttgaag gaaaagtaat tgatattaag agagagttga aaggtggatt tactagagga
     2641 catgcctttt ttgctgggat taatgagtat gatggagagt attctatatt attccaaaat
     2701 gagaatttaa ttgccaaaaa aggtgataca ccactttgta ttacaccaga tttaatagca
     2761 gtattagatt tagaaactgg atttccaata actacagaga gaataaaata tggctctcgt
     2821 gttatggtag tagcttttcc ttgtaatgaa aaatggagaa cagaaaaagg aattgagaca
     2881 gttggacctg gatactttgg atatgatgtg gaatataaaa cagtagaaga attacaagga
     2941 aaataaaagt ttaggaggaa attttgatgt atcgtgtagg aattgacgtt ggaggaacaa
     3001 atacagatgc ttgtatactg gatggggaat taaaagtaat tcattcagtt aaggtggcaa
     3061 ctacaaaaga tgttgaaact ggtgtttaca atgccttaaa aaaagttata gatgaaagta
     3121 agattgacca ttcattaata aaatatgcta tgcttggtac aactcattgt acaaatgcta
     3181 ttgtagaaag aaaaagactt aataatgtgg ctatgataag aataggaaag ccggccacta
     3241 ctgccattct tccatttata gattggccag aagacttaag agaaaaaata gaattagatt
     3301 caatattggt atctggtgga tatgagtttg atggcagaaa aataaatgaa ctttgtaaag
     3361 atgaagttgt agagttttgc aatagaataa aaggcaaagt ggaaagtgtt gcaataagtg
     3421 gagtatttgc tccagtaaat aaacaacaag aagaagaagt tgcaaaatgg gttagagaaa
     3481 ttttagggga tattcctata tctttatcaa atgaaatagg taatataggt atattagaaa
     3541 gagaaaatgg agctatttta aattctgcat tgtctcaagt aggtaaagct gtatctttag
     3601 gatttgaaaa agcacttaaa gatttaggta tagatgctca aatatatttc agtcaaaatg
     3661 atggaacatt aatgaattta gagtatacaa tgaaataccc aatttttaca attggatgtg
     3721 gaataacaaa ttctataaga ggagcttcct tcttatcaaa agtaaaaaat gcaatagtat
     3781 tagatgttgg tggaactaca agcgacttgg gtgtactata taatggattc cctagagaat
     3841 catctattcc agttacaatt ggaggagtac atacaaactt tagaatgcca gatgttttaa
     3901 ctattggtct tgctggtggt acatgtgtaa aaggcgaaaa agataatata aagataggtc
     3961 ctgaaagtgt gggatataga ataactgaag atgcaataat atttggtgga gacactctaa
     4021 ctttatcaga tgttgttaca aaattagata tggcgtttga agatagaaaa agcaatgttg
     4081 aaaacttaga taaagagtat tgtaatgagg tatataagaa ggttatttta aaattagaag
     4141 atgctgtaga ccaaatgaag actagtcaag atgatgttga attggtttta actggtggag
     4201 gaagtataat tgttcctgaa aaactaaaag gcataagcaa tgttataaga cctcctcatt
     4261 atactgctgc aaatgctatt ggtgcagctt taggacaaat aagtggagat gtagaaaaag
     4321 tatacagttt agataaaatg tcgagagaag atgccataga agatgcaaaa aaagaggctg
     4381 taaataaagc tctaaaagct ggtgctaaag aagatactat agaagtatta aatatagaag
     4441 atgttccact tgcatacctt cctggtaatg cacttcttat aaaagtaaaa gttgttggtg
     4501 atttaattta aagaataaat ataagtattt ccagaattat ataaatattt ctggactcat
     4561 ttttaaactt attttatcaa taaaaacagc ataacttttg actatattct tataagtttc
     4621 cgaacagccg atatatacct attttttgag gtttatcggc tgtttgttat cttttatcgc
     4681 attccaacta tttttcttac cgtatttgct gtacgaattg taatcttatc acttacattt
     4741 gaactggcag tctttgacca ccaatttgtc tttttataat ctttacgact aaaagaccaa
     4801 aagatagcat ttttataatg atatactttt tcatactctt ctttaggatt tccaacctca
     4861 tcataaaact cgtcataaga taagtcagga aacataaaaa taagattatc atatatttct
     4921 ttgttgttat ctccccacca attaggagca ttatttagta tatcttttaa ctcttcttgt
     4981 gaaataataa aaactggtat ttccaattca aactgttttt ttatcattaa tcttattgta
     5041 tttgagataa ccttgctgtc atctacatca cttaaaaaga caacattacc actattaagg
     5101 tatgtagaaa cttctgaata accaagttct acaaagcttg cttttaattc agacataatt
     5161 atcttgttct taccacttat attgatacct cttaataatg cgatataact tttcatataa
     5221 taatttcacc tctaaacatt cacatttttc tatgtagtac aaacttgaat ttgcatcttt
     5281 tataattctt tcaaaacttc ttcatatgta atttttttaa tataaaaaaa tcggtgctta
     5341 atttgtaccg atttttgttt ttcctagtaa agaactcgtt tttttgcttc tgctatagct
     5401 ctagcagcac tttttgcttg cattcttttt tcttcttctt ttttaaattc atttattgtt
     5461 tcatttagat tcttatcatg ttcatttttt tctttatctt cgttttctct gtatactaat
     5521 atataatcta ttattgattc gtttattatc tgagatatac ttttattttc attaattcct
     5581 attctcttaa cttccttaag tagagtctca tcaatatgaa ccgttgtttg ctttgtattt
     5641 tttgccacct taatcacctc ttaaaaaaaa ttctaacatt aaaatttttt ttagtcaata
     5701 aattttaata ttaaaattct ttaaatgttt tatttgattt tctaaaattt tctattgtat
     5761 ttatcatctt attttttata ttttcaccta gtacagaaga ctttagtcta ggattttcga
     5821 tatggtcata aattggttct aaaaattcaa cttcgacagg aacagagtta attttaccaa
     5881 taggttggta tccttcataa gtatcttttg aattttttat tacgagtgga acaatagggc
     5941 attttgcttt atatgctatc tttaaagctc cacttctaaa ctccgaaacc aatgaatttg
     6001 gttctttaat ccatgttaaa tctccttctg gaaacactgc catactttga cctgtaagta
     6061 tattttgaga ggcttgggct atactcttta taccctcacg attgtttttt ctgtttacat
     6121 atacacatct tagtaatttt gcccattctt taaatatagg tatatttctc caaactggtt
     6181 catctgcaat tacacatcca attggtcttt ctacacttgc tgttagtatg aagctgtcaa
     6241 gcatactaga atgatttaca acaaatagaa gtggttcttt tggcagtgtt tccttaccaa
     6301 ttatattaag ctctatattc actatatcta aagatttttt agcttgtttt tgcataaatt
     6361 caaatttttc ctttaagcta aatttatcag gattcttttt aattttaata agcctaggta
     6421 tagaagatgt aaaacctata agttgatatg tagcaaattt taagtaatta ttcataaaat
     6481 tatctcctta aaataaaatt atttattact gtaaagattt taacataaaa taaaatttaa
     6541 gtctatttta attcaatttt gtaacatata ttttaaatag acagagattg agattttata
     6601 tttccaattt tagtaatcag attttatcaa taaattacta ttctattaat ttaattaaat
     6661 aacctttaaa tttaattata aaaactgttg cagaaatttc tacaacagtt taaaaaattt
     6721 accttacaaa aacttatttt ataacaagag agtatattat aaggctagta cagcccattt
     6781 tttgcactga gaaattcttt tgccatcatc accttgttct ttgtcatatg caaattgatt
     6841 aagcatttca catggaaatg tatcacatag accacaatgt gtaaggtttt tatcttcaca
     6901 acaagatttt acaggacatt gttcacccca aaatggtttc tcaatctctg tacaaccttt
     6961 acaattgact ttttccttgt atccacattc ataacataaa attccacatc ttgattctat
     7021 cattttaagt cactccttaa atataaattt tatatgattg tatatcaaaa tttatacttt
     7081 tcattgtaaa aatcggacaa attttttata taggttgttg gattaacacc acaaatagat
     7141 ttaaaatcat ttataaaatg agattggtcg taataaccaa tatcttgtgc taaagttgca
     7201 aatggtattt tattattttg tatttcttgt aatacaaggt ttatacgaag taatctaagg
     7261 tatgatttaa cactcatacc aagagaatta ttaaaaattc tatttaaatg tcgttcacta
     7321 taacaactaa tttgtgaaat gtttttaaca gacataatag agttttgttt tctagcattt
     7381 tcaagaattg gtatagtcat atctactata tttgatttca ataagtatga taagaataac
     7441 atatctaatt gttctactaa ttcctttata gtacttgttc tttcaaaaat ggaattaacc
     7501 tctaagctaa ataatgtgtt aaaatcttca agtgaaattt ttaaatctgt agattctctt
     7561 tgagaaagac ctgtcaaata atatactcca cctgggcgaa actcaacgaa tactctaaaa
     7621 agtacatttt ctatatcatt ttttacaata gtagtttttg ttgtggctcc ccagaatgcg
     7681 ctttctatac cttttttgtc aaatttaaat atcatacatc cactagcatc aggtattaat
     7741 gtaagatttt ctttaatact tgtatctgga atagatattg tatagtgtgc tatatactgt
     7801 cttaacaatt tatgtggcaa aatatatgta tactgtttgc aggtatttaa aatgttattg
     7861 attattttat tcataagtat atcctcctga tatataaaaa ataa
//
LOCUS       DAEQCW010000138         7812 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.139, whole genome shotgun sequence.
ACCESSION   DAEQCW010000138 DAEQCW010000000
VERSION     DAEQCW010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7812)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7812)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7812
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.139"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            950..2308
                     /locus_tag="KRO40_003221"
     CDS             950..2308
                     /locus_tag="KRO40_003221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBH2094019.1"
                     /translation="MKAKSTSKFELDGIPPLKEAIPLGLQHLMAMVIGSCLPAILIAN
                     AAGLNHKMSTLLIQAALVFAGLSTLLQLYPIPLFKGFKLGGGIPVIMGATAMFIGAGV
                     SVASKYGLPVLFGSQIIAGIVIIIIGFGLKKIRFIFTPAVSGTIVACMGLGLFPIAIK
                     NLAGGMGNETFGNPINFIVGISVSLMILGLNKYGKGLFKDASILVSIIFGYILSLILG
                     IVNFSSIQEFTLVALPKPLAFGLDIRLEVVVMFSIIYLVEIADIMGACTLSAVGGLNR
                     QVTDEELSSAVLGNGVLSTIGALFSATPMGMFGQNSAIVSNTKVVSKFVLAIGGIGLF
                     LAGISPLLANLIRTIPPCVVGGATLVIFSTLTTSGLRLVSMDGFNQENSMILGLSMAS
                     GIGFMVAPQVLEKFPKFIETLLADSSVVSGAMVAIIIQALYMVKFPGNKSDKVEDKNK
                     SL"
     gene            2415..3209
                     /locus_tag="KRO40_003222"
     CDS             2415..3209
                     /locus_tag="KRO40_003222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBH2094020.1"
                     /translation="MVTIKEYSVPQSLEEAYKILISKKNNVILGGCGFIKLSNKNIGT
                     AIDLKDINLNYIKEDKKNILIGADTSLRSLEIDKTIKNYCSGILSSAVSNIVGVQFRQ
                     GARIGASVFSKYGFSDLIPALLVVGAKVRLYNKGILELSEFLDSELSRDILVEVILPK
                     KDAIAVFDSIRKCTGDFSVLNSAMLKENDTYKIAIGARPQKARLALEASNILNKEKDI
                     DKASIVASKELTYGSNMRASKEYRKDMASALVKRMYNAIEEGMYND"
     gene            3202..5508
                     /locus_tag="KRO40_003223"
     CDS             3202..5508
                     /locus_tag="KRO40_003223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBH2094021.1"
                     /translation="MINKGIRKIDSTAIVTGKPLYTEDLIMHKDVLTLKLLRSPHAHA
                     KIKNIDTSKAEKIPGVVGIYTYKDVPQVRYCVPGQTEPEASPYDRVLLEDTVRFIGDE
                     VALVAAEDEKTALKALKMIKVDYEVLKPVFDAREAEGNEVVIHPEKDIVEPYPFGLDA
                     KNNIVSKEFFEFGDVEAKLKESDFVVESSYKTQSQSHCMMETHRSYSYKDINDRIVVV
                     SSLQSPHNVKRILRKVLGIPSSKIRVIKPRIGGGFGGKNIAATDIFTAFVTMKTGRPA
                     KFVFTRSETFVGSNSRHEMFFDVKVGADKEGNLKAIELKSLNNTGAYGGNGVSVSSES
                     GHNTLPIYNDIDAVRFNARTVYTNRLPAGALRGYGATQGIFAIDSAIDELAHKIGMDP
                     LEFRIKNIIDRYTNGKAAEDEILSCELRQCIEKGKKLINWDDKYPCKDIGNNKVRAVG
                     MAVANHGSGIPRVDMATVTIRMDEDGTYKLLSGLADLGQGADTIQAQIAAEALNTTVD
                     RISIYTGDSDLCPYDTGAFASCTTTVTGNATIKTANKLKDILLSVAESKLGFKKEDLE
                     LGKDRVFVKNDNSKFVLLEELGRESVGGIGFASDDVPVVLEATESFGMLKKIKPFIAG
                     FAEIELDKNTGEYKVINFACVPDCGTVINPTLARIQVEGGVMMGIGFAMYEDPIFDKD
                     GRLLTDSFLQYKVPTKKEVGNILVDFAENFDPGGPYGAKSLGEIVIHTPAPAIANAIF
                     NATGVRLRELPMTFEKVYMGMKNNNKQL"
     gene            5647..6924
                     /locus_tag="KRO40_003224"
     CDS             5647..6924
                     /locus_tag="KRO40_003224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2094022.1"
                     /translation="MSNRIKNIHYGTQRQQLKNLTKKEYQALREMCFLAKNLYNVGTY
                     NVRQHYFNQGEHLNYEANYHVCKENENYKLLNSNIAQQILKEVDSSFRSFFGLIKLAK
                     EGKYDFRGIKSPKYLDKEGFFSIIIGQIRIKEDGILNVPMSPAFKKLYGKVSIKVPQN
                     ILEKKIKEIRIIPKHKARFFEIQYCYEIPKSEEVSNQKNALAIDLGLENLCTCVTNLG
                     DSFIIDGKRLKSVNQWANKQNDKIEALKLKKNITAITRKQFKVWNKRNNQVKDYVNKT
                     CFYIIDYCVKNNIGNLIVGYNAKLEKSDNMERKIYRNFIRIPFGEIKGKLEYLCKIKN
                     INFIRQEESYTSKSDFFADDFLPDINVDNVKKYDFKGERITRGQYKSSVGIIINADVN
                     ASLNILKKSQVVNLSNLQNNPQILKQPQRVRIS"
     gene            7107..>7812
                     /gene="yqeC"
                     /locus_tag="KRO40_003225"
     CDS             7107..>7812
                     /gene="yqeC"
                     /locus_tag="KRO40_003225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative selenium-dependent hydroxylase
                     accessory protein YqeC"
                     /protein_id="HBH2094023.1"
                     /translation="MELSNIIEKNEIITVVGAGGKTSLINYFANFYRDKLKVLLTTTT
                     KIYVPNDYDNIIITIDGTVIPSICHGITVCGSYINNENKLVSIDSSILDEIVDQFDLV
                     LIEGDGSKRKKLKGWNAKEPVVYHKTTKTIGILDITSFGMNINEENIHRVEIFKKIAN
                     LDTSSINSSSTVSIENLKNIVLNPNGLFKNYSGKRVLFINKVENEKYKNLAIKLIENI
                     KEYESEIEIFYGSVKQK"
BASE COUNT         3077 a          843 c         1457 g         2435 t
ORIGIN      
        1 gtatatttta tgttgcagat acaaatatag taaaggagag tacattggta caactgagat
       61 acatagctta ttaagttttt ctgtcttatg agaattatat tataaaatat tcataaatat
      121 tttgagttta aattaaataa ttattttatg cttagattaa ttgatattta attaatttaa
      181 taacaaaaac agtgaaagag taaataatat tatttacagg gggtaaagca aagtatgtta
      241 aataaattgt acttttggcc ccgtacatag agaaatctat gtaggacaca actttaaaac
      301 cagtaaatcc taaagccttg caactacaat aaaagataga aagaaacttt tatgaatgtg
      361 gtgaaaacca gaaacaatag tgaggatggt atatggtgag agcctaagta cttaaaaatg
      421 gacatttggt cgccaagcct agaaatagga aggtcaaacg actatctcga gagagagtac
      481 actataagcg attgatagtg gaaacgggtt gctcttagca ggtaatgctg aagatgaaga
      541 aatagtctac gctcatatga aagtatgagg tcactggatt tgaagtgaca tctataaagt
      601 agcgtttata ggtaaatgtt taaaacttga aacatgtaaa tacttatgaa aacttataac
      661 ttataatgat taagattgaa agatttaaat tgaattaaat ttactataaa aaattaaaaa
      721 ttcatagcta taatactctt atatttgtaa agcatggtat ataatgtata caaaattaaa
      781 gaatacgtgt atttgttaat aattaaattt attgcatctg ttttttaaga ctaaaaactt
      841 aaatatatgt tggagtatag ttgatattta tgaacatcat taatttaata tattagattt
      901 ttaagtattt atataattca ataagtttta tgtaacggga gtttttatta tgaaagcaaa
      961 aagtacatca aaatttgaat tagacggaat accaccacta aaggaagcaa tacctttagg
     1021 gttacaacac ttaatggcaa tggtaatagg tagttgttta ccagcgatat tgattgcaaa
     1081 tgcagctgga cttaatcata agatgtcaac attattgatt caagccgcat tagtttttgc
     1141 aggattatca actttattac aattatatcc aatacctttg tttaaaggtt ttaaattagg
     1201 aggaggaata ccagttataa tgggagctac agctatgttt ataggagctg gggtatctgt
     1261 tgcaagtaag tatggactac cagtattatt tggctctcaa ataatagctg gtatagtaat
     1321 aattataatt ggttttggtc ttaaaaaaat acgatttata tttactccag ctgtatcagg
     1381 aacaatagtt gcatgtatgg gtcttggact ttttccaata gctataaaaa acttagctgg
     1441 gggtatgggc aatgagactt ttgggaatcc aattaatttt atagttggaa tatctgtatc
     1501 tcttatgata ttaggattaa ataagtatgg aaaaggatta tttaaagatg catcaatatt
     1561 agttagcata atttttggat acattttatc attaattttg ggtatagtaa atttttcttc
     1621 aattcaggag tttactttgg ttgcacttcc aaaaccactt gcttttgggc tagatataag
     1681 acttgaagtt gttgtaatgt tttcaataat atatttagtt gagatagctg atataatggg
     1741 tgcttgtaca ctttctgcgg taggagggct taatagacaa gtaacagatg aagaactttc
     1801 ttctgctgtt ttaggaaatg gagtactctc tacaataggt gcattatttt ctgcaactcc
     1861 aatggggatg tttggacaaa attctgcaat cgtttccaat acaaaggttg taagtaaatt
     1921 tgtactagct attggaggaa ttggattatt tttggcagga atatcgcctt tattagctaa
     1981 tttaataaga acaattcctc cctgtgtggt tggaggagca acactcgtta tattttcaac
     2041 tcttacaaca tctggtttaa gacttgttag tatggatgga tttaatcaag aaaatagcat
     2101 gatattaggt ctttctatgg cttctggtat tggattcatg gtagctcctc aagttcttga
     2161 aaaatttcca aaatttatag agacattact tgcagattca agtgtagttt caggagcaat
     2221 ggtagccata ataattcaag ctttatatat ggtaaaattt cctggaaata aaagtgataa
     2281 ggttgaggat aaaaataaaa gtttataatg taaaggttta atatatgtga attaaatata
     2341 ctacaattat aaatataaat aaaagattta ttaaaaactt ttgtgtttta ataagttaat
     2401 gatgggggga taagatggtt actataaagg aatattcagt tccacagagt ttagaagaag
     2461 catataaaat tttaatttct aaaaaaaata atgttatttt aggtggatgt ggatttataa
     2521 aattaagtaa taaaaatata ggaacagcga tagatttaaa agatataaat ctaaattata
     2581 taaaagagga taaaaaaaat attttgatag gtgcagatac ttcacttaga agtttagaaa
     2641 ttgataaaac tataaaaaat tactgtagtg gaatactttc aagcgctgtt tctaatatag
     2701 ttggtgttca atttagacaa ggggctagaa ttggtgcaag tgtattttca aagtatggct
     2761 tttctgactt aataccagcg cttttggttg ttggagcgaa ggtgagatta tacaataaag
     2821 gaatactaga gttaagtgag tttttggata gtgaattaag tagggatata ttggtcgaag
     2881 taatactacc aaaaaaagat gcaatagctg tttttgactc aataagaaaa tgcacaggag
     2941 atttttctgt attaaattca gcaatgctaa aagaaaatga tacttacaaa atagcaattg
     3001 gggcaagacc tcaaaaagct agattagcac ttgaagcgag taatatatta aataaagaaa
     3061 aagatataga taaggcatct attgttgcta gtaaggaact tacttatgga agtaatatga
     3121 gagctagtaa agagtacaga aaggatatgg caagtgcatt agttaaaagg atgtataatg
     3181 ctattgagga gggaatgtat aatgattaat aaggggataa gaaagataga tagtacagca
     3241 attgtcacag gaaaacctct atatactgaa gacctcatta tgcataaaga tgttttgaca
     3301 ttaaaactac ttagaagtcc acatgctcat gctaagataa agaatataga tacatcaaaa
     3361 gccgaaaaaa ttccaggggt tgtgggtatt tatacgtata aagatgtacc acaggtcaga
     3421 tattgtgtgc caggtcaaac agaaccagaa gcatcacctt atgatagagt tttacttgaa
     3481 gatacagtta gatttattgg agatgaagta gctttagtgg ctgctgaaga tgagaaaacg
     3541 gcacttaaag ccttaaaaat gataaaggta gattatgagg ttttaaagcc tgtgtttgat
     3601 gcaagagaag cagaaggaaa tgaagttgtt atacatccag aaaaagacat agtagagcca
     3661 tatccttttg gattggatgc aaaaaataat atagtatcaa aagaattttt tgaatttgga
     3721 gatgttgaag ctaagcttaa agaaagtgat tttgtggttg aatcttcata caaaacccaa
     3781 agtcaatcgc attgcatgat ggaaactcat aggtcatatt catataaaga tataaatgat
     3841 agaattgttg tagtttcatc attacaatca ccacacaatg taaagagaat acttagaaaa
     3901 gtattgggta taccatcttc aaaaataaga gtaattaaac ctagaatagg tggtggattt
     3961 ggaggaaaga atatagcagc aacagatata tttactgcat ttgttactat gaaaactggt
     4021 agaccagcaa aatttgtatt tacaagaagt gaaacttttg taggttctaa tagtagacat
     4081 gaaatgtttt ttgatgttaa agttggtgca gataaagaag gaaatttaaa agcaatagag
     4141 ctaaagtcat taaacaatac aggtgcttat ggtgggaatg gtgtctctgt ttcttccgaa
     4201 tctggacaca ataccttacc aatatataat gatattgatg ctgttagatt taatgctaga
     4261 acagtatata ctaataggtt accagcagga gcacttagag ggtatggtgc tacacaggga
     4321 atatttgcaa tagatagtgc tattgatgaa ttggcacata agattggaat ggatccactt
     4381 gaatttagaa ttaaaaatat aatagatagg tataccaatg gaaaagcagc tgaagacgaa
     4441 atattaagtt gtgagctgag acaatgtata gaaaagggca agaaattaat taattgggat
     4501 gataaatatc catgtaaaga tataggaaac aacaaagtaa gagcagtagg tatggcagta
     4561 gcaaatcatg gttctggtat accgcgtgta gatatggcaa cagtcactat aagaatggat
     4621 gaagatggca catataaact attatctggt cttgctgact taggtcaagg ggctgataca
     4681 attcaagctc aaattgctgc ggaagcttta aatactactg tagatagaat ttctatttat
     4741 acaggtgatt cagacttatg tccctatgat acaggagcat ttgcttcttg tacgacaacg
     4801 gttacaggaa atgcaacaat aaagacagca aataaattaa aagatatatt actttcagtt
     4861 gcagagtcaa agctaggatt taaaaaagaa gatttagagt tgggaaaaga cagggttttt
     4921 gttaaaaacg ataatagcaa gtttgttcta ttagaggaat tgggtagaga atctgttgga
     4981 ggaataggat ttgctagtga tgatgtacca gtagttttgg aagcaacaga atcttttggc
     5041 atgttgaaaa aaataaaacc atttatagca ggatttgcag agatagaatt agataaaaat
     5101 acaggcgaat ataaagtcat aaattttgca tgtgtacctg attgtggaac agttataaat
     5161 ccaactttag ctagaataca agtagaaggt ggtgtgatga tgggtatagg gtttgcaatg
     5221 tatgaagacc ctatatttga taaagatggt agattattaa cagatagttt cctacagtat
     5281 aaagttccta caaaaaaaga agttggaaat atattggtag attttgctga gaatttcgac
     5341 ccaggaggtc cttatggtgc taaatcatta ggagaaatag ttatacatac accagcacca
     5401 gctatagcaa atgcaatatt taatgctaca ggagttcgtt taagagagct tcctatgact
     5461 tttgaaaaag tttatatggg tatgaaaaat aataataaac aattataata aataataaga
     5521 tgtataaaag caagtaaatt taaattattt tgtaaaataa agtaattaaa tggacattat
     5581 atatggtgtt ttgtaaaaat accgtatata atgtctagta gagtatattc taaaggaggt
     5641 gagttcatgt caaacagaat aaaaaatata cactatggaa ctcagagaca acaattaaaa
     5701 aacttaacta aaaaagaata tcaagctcta cgagaaatgt gcttcttagc taagaactta
     5761 tataatgttg gtacatataa tgtaagacag cattatttca atcaaggaga acatcttaac
     5821 tatgaagcta attatcatgt atgcaaagaa aatgagaact ataagcttct caatagtaat
     5881 atagcgcaac aaatattaaa agaagtagac agttcgttta ggtcattttt tggattaatt
     5941 aaattagcca aagaaggaaa atatgacttt agagggataa aatcacctaa atatttagat
     6001 aaagaaggat tttttagcat aataataggt caaataagaa tcaaagaaga tgggatttta
     6061 aatgtaccta tgtctccagc atttaaaaaa ctatatggga aagtaagtat aaaagttcca
     6121 caaaatatac tagagaaaaa aattaaagaa ataagaataa tacctaaaca taaagctagg
     6181 ttctttgaaa ttcagtattg ttatgaaata ccaaaatcag aggaagtttc aaatcaaaaa
     6241 aatgcactag ctatagactt gggtttagaa aatttatgta catgtgttac caatttaggt
     6301 gatagtttta tcatagatgg aaaaaggcta aaatctgtga atcagtgggc aaacaaacag
     6361 aatgataaaa tagaagcctt aaaattaaaa aagaatataa ctgcaataac aagaaaacaa
     6421 tttaaagttt ggaataagag aaataatcaa gttaaagact atgtaaataa aacctgtttt
     6481 tatataattg attattgtgt aaaaaataat attggaaatt taattgtagg atataatgct
     6541 aagttagaaa aaagtgataa tatggagaga aaaatatata gaaattttat aagaatccca
     6601 tttggagaga taaaaggaaa attagaatat ctgtgtaaaa taaaaaatat caattttatt
     6661 aggcaagaag aaagctatac tagtaaatca gatttttttg ctgatgattt tctacctgat
     6721 atcaatgtgg acaatgttaa aaaatatgac tttaaagggg aaagaataac gcgtggacag
     6781 tacaaatcca gtgttggaat cattataaat gcagatgtaa atgcgagtct taatatacta
     6841 aaaaaatcac aagtagttaa tttatctaat ttacagaata atcctcaaat attaaagcaa
     6901 ccacagagag taagaatatc ttaattatat ttaaaagata aactgatagc gtaagcttac
     6961 agcttagcgg cgaattggat ccgccttgtt gtttacaaca gaatctattt actttcgagt
     7021 ttatggaatt tcaaaaatca cttttactaa aaaggtctaa ctataataat taagagatta
     7081 gaaaactggt tataagaggt gaaagtgtgg aactatcaaa tataatagaa aagaatgaaa
     7141 taataactgt agttggagca ggaggaaaaa cttcgcttat aaactatttt gcaaattttt
     7201 atagagataa attgaaagtt ctccttacaa caacaactaa aatatatgta ccaaacgatt
     7261 atgacaatat aattattaca atagatggaa ctgttattcc atctatttgt catggaataa
     7321 cagtctgtgg cagttatata aataatgaaa ataaattagt aagtattgat tcctctattt
     7381 tggatgaaat tgtagaccaa tttgatttag ttttaataga gggagatggc tcaaagagaa
     7441 aaaaacttaa aggttggaat gctaaagaac cagtagtata tcataaaact acaaaaacca
     7501 tagggatatt agatataaca tcatttggaa tgaatattaa tgaagagaat atacatagag
     7561 tagaaatatt taaaaaaata gcaaatttag atacaagtag tattaatagt agttctacag
     7621 taagtattga aaacttaaaa aatatagtat taaatccaaa tggattattt aaaaattatt
     7681 ctggaaaaag agtattattt attaataaag ttgaaaatga aaaatataaa aatttagcta
     7741 taaaattaat agaaaatatt aaagaatatg aaagtgaaat agagatattt tatggaagtg
     7801 taaaacaaaa at
//
LOCUS       DAEQCW010000139         7706 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.140, whole genome shotgun sequence.
ACCESSION   DAEQCW010000139 DAEQCW010000000
VERSION     DAEQCW010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7706)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7706)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7706
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.140"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            371..1192
                     /gene="yidA"
                     /locus_tag="KRO40_003226"
     CDS             371..1192
                     /gene="yidA"
                     /locus_tag="KRO40_003226"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HBH2094024.1"
                     /translation="MYKLIALDIDGTILNTQKRITPEVFESIQEAKRAGAKVVITTGR
                     PLPGVKELLNQLNLTDEGDYVICFNGAIIQEVKSEKIIHDVEMSLDDFDFIYNNVCKK
                     YKTKIHINTMTNLITPNETPGKYTLHEAKLNNIEVKYIQKDKIDESIKICKIMIVDEP
                     ERLEEIIQQLPKNLFNKYTIVRSAPFYLEFLGKTTNKGTALKTLCTNLNIPIENAIAV
                     GDEENDQHMIKYAGLGVAMGNARNSIKEIADYVTDTNNENGVAKVINKYILNKAI"
     gene            complement(1329..1478)
                     /locus_tag="KRO40_003227"
     CDS             complement(1329..1478)
                     /locus_tag="KRO40_003227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094025.1"
                     /translation="MNFFWTKSDFDAWTNEAGLSNDEDIYCLDINEAIVESYKIFKLK
                     QKVLS"
     gene            complement(1485..1970)
                     /locus_tag="KRO40_003228"
     CDS             complement(1485..1970)
                     /locus_tag="KRO40_003228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094026.1"
                     /translation="MSQIEKYNSLDNTQQKIRISIMDMIIDKGSSVTLQEVTEYISKK
                     LNIEKEYIERTLQYFIYKNIMVVDGNSINFIYPVSALPTNHKVTLRDNRSFSAMCAID
                     AIGTSCTFNQDIKINSICSATGKEIEVIIKNEKIEYVNNPNLRVLHINLDKHLNWAAS
                     C"
     gene            complement(1983..2735)
                     /locus_tag="KRO40_003229"
     CDS             complement(1983..2735)
                     /locus_tag="KRO40_003229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094027.1"
                     /translation="MKLSVRDINKTFVNNRVHTKVLEDISMDIDDGQFVCLLGPSGCG
                     KTTLLTIIGGFQKSERGDVFINDKRVKKPGIDRAFIFQNYALFPWKTIRGNVLFPMKQ
                     QKIPKEKREEMLEELLVMSDLKGKEKLFPHQLSGGMKQRVAMIRALACNPEVLLMDEP
                     LGAVDFQMRQNLQEELERIWIKKKITALMVTHDVDEAVYMSDRVIVMSRDKGRIIDDI
                     NIDIPRPRIRGSQKYEEYKNKLTDTLSKCYEV"
     gene            complement(2912..3541)
                     /locus_tag="KRO40_003230"
     CDS             complement(2912..3541)
                     /locus_tag="KRO40_003230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094028.1"
                     /translation="MEIKISKDKSDRLTKKKTDGSMDILYKIILLVIIFLVWHFAAKD
                     IGSSLLLPMPVDVIKGFFFCVTDAETVTNLFITLQRVLKGFMYALLFGLPIGFIMGFS
                     KTFERVLSPVVDSVRQVPIMAWVPLTIVWFGIGDGPTIFLIAFSGVFPIILNTIQGVR
                     AISKDYYNAARSMGASPIVIFTNVIVPASLPDILTGSRIAISTGWMSVI"
     gene            complement(3502..4065)
                     /locus_tag="KRO40_003231"
     CDS             complement(3502..4065)
                     /locus_tag="KRO40_003231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094029.1"
                     /translation="MQWALSSEEIDIAIICKDAAKQYVNVNSGFEIVGTVVQNSDIFL
                     LSDNNPEKIGVIQNRDYQSELVKKYYKNVEVAPLLGTALAYGLESNLVDGVVIDCIKS
                     IGLEGKRKSTTKLGDYDTYVLVVSKEFKKSKAYSDFITLYNKSVDALKNKATFKKALK
                     EYRNIRNIDMEEISNWKLKFLKIKAID"
     gene            complement(4075..4299)
                     /locus_tag="KRO40_003232"
     CDS             complement(4075..4299)
                     /locus_tag="KRO40_003232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094030.1"
                     /translation="MENMKNIIILFIIILGSIFIIFFNFEDKEEIKGKLRIGVSDDTS
                     GFVINYMVNRDYFENIKVSDIMDIFTINDC"
     gene            complement(4304..5395)
                     /locus_tag="KRO40_003233"
     CDS             complement(4304..5395)
                     /locus_tag="KRO40_003233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2094031.1"
                     /translation="MKLSKKIQALILFGVMGTSILTGCSSKPKEKEEAKTGKDDYTIT
                     VGYYNCDHMTAGPVAESAGIYKDLGLNVKTVGNGKVPEAMAAGKMDAGYIGTKGLVGA
                     IPKGSPITIAANNHTGGSEYLIVSKDIKEPKDLIGKKIATDMSDFLWTSDYGPETGLP
                     TDPSKYEVVNMDSDKDKYLALKTGKIQAFTSCDPWGSVAENDGAGKIIASTQYKEKAN
                     GKEYNCCSFSLNKNFIKEHPDLAKKLVLAHTKAIEYIYTNPAEAAKIFAKYYNVEEEV
                     ALRTIYKKTVGEGRTLTWKVTGEEYKNNLQMYKDLKALDDIPKYEDTIDTSLLDSCGA
                     DDFDKFIKEKVNPEFPEGMSYEDWKAKVL"
     gene            complement(5430..5888)
                     /locus_tag="KRO40_003234"
     CDS             complement(5430..5888)
                     /locus_tag="KRO40_003234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094032.1"
                     /translation="MLKKIVIISCIVVVLIILSKIVDDNIKEDASIPNVNKETLEYFR
                     KNYKEDIITCAEEDLNNDGKKDLVVIYKKSNNSNEMVVVVSDKNSHYITKPIPAPIEN
                     QTITFKNIDDKAPIEVIVSGSKNGNVGYAIYRVEGKKFVDLFGEDMDKCC"
     gene            complement(5881..6966)
                     /locus_tag="KRO40_003235"
     CDS             complement(5881..6966)
                     /locus_tag="KRO40_003235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBH2094033.1"
                     /translation="MNILEIVLNGVKDTIVASIVTLNGASGWLMISFILAGVLHNVLT
                     PRRFQKQLGNKKFSSLIKSTISGMFLPICSCGVIPLGISMYYSGAYLGPVLAFMTSTP
                     IINPIAVVLCLGLLGPKVTIIYLIAGFLVPFLVGFLGNCFGKEELSLHNDSEEEVIEL
                     EEEKRSFMENMIDGLKWSFGELALTISKYVVMGMVFAGFITTIFPNSIIQKYLGNPGL
                     LSLGSIAILACVMYVCAVGHIPFIAALVASGASPGIAITFLIAGAATNLPELISMFKL
                     IGKRTVIIYSVTLTLSSIIIGYITNLLLVNNNSVNLDATNSSIQLANKLMLNIPDSFE
                     YVCTILIILFAFKSIIPKMKEVIGNHA"
     gene            complement(6993..7178)
                     /locus_tag="KRO40_003236"
     CDS             complement(6993..7178)
                     /locus_tag="KRO40_003236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094034.1"
                     /translation="MSEKYADKLEIKLYQAGKDFSYIKKYGIITKGTLIINQKKKYDR
                     LNKDTIERAIVEAINNN"
     gene            complement(7340..7672)
                     /locus_tag="KRO40_003237"
     CDS             complement(7340..7672)
                     /locus_tag="KRO40_003237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DsrE family protein"
                     /protein_id="HBH2094035.1"
                     /translation="MKVAYIFSSTNTHKILDKMIIPQLEQGTHGVDVLGMFFFMDNTL
                     FLSKGNPVGERLSKLHEKTDMIIMACDQCAIERGIENNLVDGATIGCFPNLYACLGSA
                     GVDQVITL"
BASE COUNT         2536 a         1358 c          855 g         2957 t
ORIGIN      
        1 aataataaca tatgattaat ggaattacaa tattttataa cacaaaacta actaatataa
       61 caaattacca tcagtctatt tattcaaact tctaactata taatatacat ttatttatat
      121 taacaatgca aacgatacca ttatttgtaa ttaagaattt tggaattatt gattacaaag
      181 tttttacatt ctcatctcac ataagtaata tttttatcaa aaaattaata ttattaaact
      241 ttctaaatta cttatctctt gatataatag tatacaaaac aaaccatatt tcccactgaa
      301 actttgttca acactagctg tgtcaacgtt ttcacaggaa atttgagtat ataatttatt
      361 ggaggttgat atgtacaaat taatcgcact agacattgat ggaacaatat taaatacaca
      421 aaaaaggatt actcctgaag tctttgagtc cattcaggag gcaaaaaggg ctggggcaaa
      481 agtagttata acaacaggca gacctcttcc tggtgtaaaa gaacttctaa atcaactaaa
      541 tttaacagat gaaggtgatt atgttatatg ctttaatgga gcaattattc aagaagttaa
      601 aagtgagaaa atcatacatg atgtagaaat gagtttagat gattttgatt ttatatataa
      661 taacgtttgt aaaaaatata agactaaaat acacataaat acaatgacaa atttaattac
      721 accaaatgaa acgcctggca aatatacact tcatgaagcg aaattaaata atatagaagt
      781 caaatatata caaaaagata aaattgatga atctattaaa atctgtaaaa ttatgatagt
      841 tgatgaacca gaaagattgg aagaaatcat acagcaacta cctaaaaatt tattcaataa
      901 atatactata gtaaggtctg ctccttttta tctagaattt ttaggtaaaa ctactaataa
      961 aggaactgct cttaaaacat tatgtacgaa tctaaatata cctatagaaa atgctattgc
     1021 tgttggcgat gaagaaaatg accaacatat gataaagtat gcaggtcttg gtgtggctat
     1081 ggggaatgca cgtaatagta taaaggaaat tgcagattat gttactgata ctaataatga
     1141 aaatggagtt gcaaaggtta taaataaata tatacttaat aaggctatct aatcatctaa
     1201 aaaaaactaa aaatatacct ttagatttaa atacttttca catccctact ctatactaat
     1261 ttatatagta tggatattac ctatcatttt tatctaaagg tcatttttag tttttcatat
     1321 atgtatatct atgatagtac cttttgtttg agtttaaata ttttatatga ttctactatt
     1381 gcctcattaa tatctaaaca atatatatct tcatcattag ataatcccgc ttcgtttgtc
     1441 caagcatcaa aatcactctt cgtccagaag aaattcatta tatttcagca actagcagcc
     1501 caatttagat gcttatcaag atttatatga agcactctta agtttggatt attcacatac
     1561 tcaatctttt cattttttat aattacttct atttccttac ctgtagcact acaaatagag
     1621 tttattttta tatcttggtt gaatgtgcaa gaggttccta tagcatctat agcacacatt
     1681 gcactgaaac ttctattatc tctcaaagtt actttatgat ttgttggcaa tgctgataca
     1741 ggatatataa aatttatact attcccatca acaaccatta tatttttata aataaaatat
     1801 tgtagtgtcc tttctatata ttctttttct atattcaact ttttacttat atattcagtc
     1861 acttcttgaa gtgtaacact agaaccttta tctattatca tatccataat agagattctt
     1921 attttctgtt gtgtattatc caaactattg tatttttcta tttgactcat gtctactcct
     1981 ctttaaactt cataacactt tgataaagta tcagttaatt tgtttttgta ctcttcatat
     2041 ttttggcttc ctctaattct aggtcttgga atatctatat ttatatcatc aataattctt
     2101 cctttatctc tcgacattac tataactcta tcactcatat atacagcttc atcaacatca
     2161 tgagttacca ttaatgcagt tattttcttc tttatccata ttcgttctag ctcttcctgt
     2221 aaattttgtc tcatttgaaa atctacagct cctaatggtt catccattag taatacctct
     2281 ggattacatg ctaaagctct tatcatggcc actctttgtt tcattcctcc agataattga
     2341 tgcggaaaca gtttttcttt tcctttcaag tctgacataa ccaaaagttc ttctagcatt
     2401 tcttctcttt tttcttttgg tattttctgc tgtttcatag gaaatagaac attacctctt
     2461 atagttttcc aaggaaataa agcataattt tgaaatataa aagctctatc tatgcccggt
     2521 tttttaactc ttttatcatt tataaaaaca tctccacgtt ctgatttttg aaacccacct
     2581 attatagtaa gtaaagttgt ttttccacaa cctgatggtc ctaaaagaca gacaaattgt
     2641 ccatcatcta tatccatact tatatcttct aaaacctttg tatgtactct attatttaca
     2701 aatgtcttat ttatatctct tacacttaac ttcattaatc tgcaaacctc catctacaaa
     2761 ggattttatt tataaacttt aataccctat ctattataaa tcctattaaa gctgcaaata
     2821 tcataagccc aattaataca tctgtatgca ttaatgtttg agcttgtacc attgagtaac
     2881 cgagaccggc actcgtagct ataaactcgg ctcagataac agacatccat cctgtactta
     2941 tagcaatcct tgaaccagtt agtatatctg gaagagatgc gggaacaatt acatttgtaa
     3001 atatcacaat tggcgatgct cccatacttc tagctgcatt ataataatcc tttgatattg
     3061 ctcttactcc ttgaatagta tttaaaatta tagggaaaac ccctgaaaaa gctattaaaa
     3121 atattgttgg accatctcct ataccaaacc atactatagt aagaggaacc catgccatta
     3181 ttggaacttg ccttacagaa tctactactg gagataaaac cctttcaaaa gttttagaaa
     3241 atcccataat aaatcctatt ggaagcccaa acaataatgc atacataaaa cctttaagta
     3301 ctctctgcaa tgttataaaa agattagtga ctgtctctgc atctgtcaca cagaaaaaga
     3361 aaccttttat tacatctact ggcattggaa gtaacaaaga actccctata tcttttgctg
     3421 caaaatgcca gactaaaaat ataataacta atagtattat tttatataaa atatccatac
     3481 taccatcagt ttttttctta gttaatctat cgcttttatc tttagaaatt ttaatttcca
     3541 attgcttatt tcctccatat ctatatttct tatattcctg tactctttta atgctttctt
     3601 aaatgtagct ttattcttta aagcatcaac acttttattg taaagtgtta taaaatcact
     3661 atatgcttta ctttttttaa actctttact tacaactaat acataggtat cataatctcc
     3721 taatttagtt gtagattttc ttttgccctc taacccaatt gactttatgc aatctattac
     3781 aacaccatct actaaattac tttctaatcc atatgctagt gcagtcccta ataagggagc
     3841 tacttccaca ttcttgtagt attttttaac caattctgac tggtaatctc tattttgaat
     3901 gactcctatc ttttcaggat tattatcact taatagaaat atatcagaat tttgaactac
     3961 agtaccaaca atttcaaatc cactatttac atttacatat tgttttgcag catctttaca
     4021 tatgattgct atatctattt cctctgaact cagagcccac tgcattgtac ttgctcagca
     4081 atcattaatt gtaaaaatat ccattatatc acttactttt atattttcaa agtagtctct
     4141 atttaccata taatttatta caaaaccaga ggtatcatca gataccccta ttcttaattt
     4201 tccttttatt tcttctttat cttcaaaatt aaaaaatatt ataaatatac ttcccaaaat
     4261 aatgataaaa agtattatta tatttttcat attctccatt tatttataat acctttgctt
     4321 tccagtcttc ataactcata ccttcaggaa actctgggtt aactttttct tttataaatt
     4381 tgtcaaaatc atcagctcca caagagtcca ataagcttgt atcaatcgta tcttcatatt
     4441 taggtatatc atctaaagcc tttaaatctt tatacatttg taaattattt ttatattctt
     4501 cacctgtaac tttccaagta agagttctac cttctccaac agtcttctta tagatagttc
     4561 taagtgcaac ttcttcttct acattataat attttgcaaa tattttagct gcttcagctg
     4621 gatttgtata tatatattct attgcttttg tatgtgctag aaccaatttt tttgctaaat
     4681 ctggatgttc ttttataaag tttttgttta atgagaatga acaacagtta tattctttgc
     4741 cattagcttt ttctttatat tgagtagatg ctattatttt tcctgcaccg tcattttcag
     4801 ctacagaacc ccaagggtca caagatgtaa aagcttgaat tttcccagtt ttaagagcta
     4861 aatatttatc tttgtctgaa tccatattta caacttcata ttttgatggg tcagttggta
     4921 gacctgtttc tggaccataa tcacttgtcc ataagaaatc actcatatct gttgcaattt
     4981 ttttacctat taaatcttta ggttctttta tatcttttga aactattaaa tattcagaac
     5041 caccagtatg gttgttagct gctattgtta ttggtgaacc cttaggtatt gctccaacta
     5101 accccttagt tcctatgtaa cctgcatcca tttttcctgc tgccatagct tcaggaactt
     5161 taccatttcc aacagttttt acattaagac ctaaatcttt atatattcct gccgattctg
     5221 ctactggtcc cgcagtcata tggtcacaat tataataacc tactgttatt gtataatcat
     5281 cttttccagt ttttgcttct tctttttctt ttggtttact actacatcct gttaatatag
     5341 atgtacccat tacaccaaat aagattaatg cttgaatctt cttagataat ttcatataaa
     5401 tttcccacct ttatgtatta tttttatttt tagcaacatt tgtccatatc ttcgccaaat
     5461 aaatcaacaa attttttacc ctctactctg taaatagcat atcctacatt accattttta
     5521 gaccctgata caattacttc tattggtgct ttatcatcaa tatttttaaa ggttatagtt
     5581 tgattctcta taggtgctgg tattggcttt gttatatagt ggctattttt atcagaaact
     5641 acgactacca tttcatttga attattgctt tttttatata taactactaa atcttttttc
     5701 ccatcattat ttaagtcttc ttcagcacaa gttattatgt cttctttata attttttcta
     5761 aaatattcta atgtttcttt attcacattt ggaatagaag catcttcttt gatgttatca
     5821 tcaactattt ttgataaaat gattaacaca actactatgc aggatattat aactatcttt
     5881 ttaagcatga tttcctatga cctctttcat ctttggtatt attgatttaa atgcaaataa
     5941 aataattaaa atagtacata catactcaaa actatcaggt atatttaaca ttagtttatt
     6001 tgccaactgt attgaagaat ttgttgcatc taaatttact gagttattat tcactaaaag
     6061 taaatttgtt atatatccaa ttattattga agacagtgtc aaagttacag aatatataat
     6121 aacagttctt tttccaataa gtttaaacat acttataagt tctggtagat ttgtagctgc
     6181 tccagctatt agaaatgtta tcgctatacc aggagatgct ccacttgcaa caagggctgc
     6241 tataaacggt atatgtccta cagcacatac atacataaca catgcaagta ttgctatact
     6301 tccaagagat agcaaacctg gatttcctaa atatttttga attatactat ttggaaaaat
     6361 agttgttata aatcctgcaa aaaccatacc cattactaca tatttactaa tagtaagggc
     6421 taattcacca aaagaccatt taagaccatc aatcatattt tccataaaac ttcttttttc
     6481 ttcttctaat tctattactt cttcctctga atcattatga agtgataatt cttcttttcc
     6541 aaaacaattt cctaaaaatc ctactaaaaa tggtactaaa aaaccagcta ttagataaat
     6601 gattgtaact ttaggaccta aaagacctag acaaagaact acagctattg gatttattat
     6661 tggagttgat gtcataaaag caagtactgg tcctaaatat gctcctgaat aatacatact
     6721 tattccaagt ggtattactc cacaactaca tattggtaaa aacattcctg agatagtact
     6781 tttaattaaa gaagaaaatt tcttatttcc aagttgtttt tgaaaccttc ttggagttaa
     6841 aacattgtga agtacacctg ccaagataaa acttatcata agccatcctg atgctccatt
     6901 cagtgtaact atagaagcta ctatagtatc tttaactcca tttaaaacaa tttctaatat
     6961 attcattttt gatactccta atttttaaac ttttaattat tgtttatagc ttctactatt
     7021 gccctttcaa ttgtatcttt atttaatcta tcatatttct ttttctgatt tattattaaa
     7081 gttccttttg ttataatccc atattttttt atatacgaaa aatctttccc tgcttgatat
     7141 aattttattt ccaatttatc agcatacttt tctgacattt tttttataaa cactccatgt
     7201 tcatcacaag atggtcaagt gtttataaat tcaactaaaa ttttagacat ttgttcatcc
     7261 cctactttaa acaatttatc ttttacttaa aataatccac agaaaataaa tttttctatg
     7321 gattgtatcc tatactaatt tataacgtta taacttggtc cacacctgca ctgcctaaac
     7381 aagcatatag gtttgggaaa catccaattg tagctccatc aaccaaatta ttctctatac
     7441 ctctttctat agcacattgg tcacaagcca ttattatcat atcagttttt tcatgtaatt
     7501 tacttagtct ctcgcctaca ggattacctt tagataaaaa taaggtatta tccataaaga
     7561 aaaacatccc tagaacgtct actccatgag ttccttgttc aagttgtggt attatcattt
     7621 tgtctagaat tttatgtgta ttagtactac taaaaatata agctactttc atttttattc
     7681 cccctatact ttttatattt tacaaa
//
LOCUS       DAEQCW010000140         7460 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.141, whole genome shotgun sequence.
ACCESSION   DAEQCW010000140 DAEQCW010000000
VERSION     DAEQCW010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7460)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7460)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7460
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.141"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            91..1068
                     /locus_tag="KRO40_003238"
     CDS             91..1068
                     /locus_tag="KRO40_003238"
                     /EC_number="6.3.4.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin--[acetyl-CoA-carboxylase] ligase"
                     /protein_id="HBH2094036.1"
                     /translation="MRDKIIEIILNNKSEFISGEELSKQLGVSRAAIWKHMKALKEEG
                     YNIESVNKKGYRLAENPTDLLSPQNIYYKLDTEFIGKNIEHLDTIDSTNEHAKRIAIN
                     SVDGTVILSEHQDMGKGRLGRRWDSKPHEGIWMSIILKPNMEPFKAPFITLIAGASVT
                     KALNNLGANTLIKWPNDVILNGKKICGILTELSAEIERTNYVVLGIGINVKIMDFEQE
                     IADKATSLYKEGYMLSRVDIVRNVLTEFEKLYLDYTVNNSKEKTLKICRDYSAIIDKN
                     IYVLKGDNRELVKCLDINEEGNLLVQRSDGSIKEIISGEVSIRGEKGYV"
     gene            1061..2029
                     /locus_tag="KRO40_003239"
     CDS             1061..2029
                     /locus_tag="KRO40_003239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P1 family peptidase"
                     /protein_id="HBH2094037.1"
                     /translation="MYNNILDIEGLKVGQVEDRNGLTGCTVVICEEGATCGVDVRGSA
                     PGTRETDLLDPVNMVQKVHAVVLAGGSAYGLESTCGVSRYLEEKGIGFDVGVGKVPIV
                     VGAVLFDLGVGSFKCRPDLKMGYRACEVANTDILNQGNYGAGCGATVGKIRGQEYAMK
                     GGIGSYSIKLDNGLVVSALIAVNALGDVYENGKVIAGALNDKKTETIDTYKLMKQGES
                     KGGFSVDNTTIGIIATNAKLTKAGCKKISQMGHDGYAKSIFPIHTPHDGDTIFTISTG
                     EIEADITLVGSLAVEVVEKSIINAVKKADSVENIMAYKDIVKKREI"
     gene            2212..2802
                     /locus_tag="KRO40_003240"
     CDS             2212..2802
                     /locus_tag="KRO40_003240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBH2094038.1"
                     /translation="MMNTSASVRKVNVRKMTIIGVLSAISIMLSMTPLGFIPVGPTKA
                     TIMHIPVIIGAIMEGPIVGAAIGFIFGISSLLNAITNPTVTSFVFINPLVSILPRVMI
                     GVLAYYVYQLIIKATNKVYISGLITGAIGSLLNTAGVLGMIYVLYADKYLHAMGKSGS
                     AGKVIMALAAANGVPEAIVGALVVAAVATVLKKSKK"
     gene            2821..3591
                     /locus_tag="KRO40_003241"
     CDS             2821..3591
                     /locus_tag="KRO40_003241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III pantothenate kinase"
                     /protein_id="HBH2094039.1"
                     /translation="MLLVFDVGNTNMVLGIYKGDKLVNYWRIKTDREKTSDEYGILIS
                     NLFDYDNVNISDIDDVIISSVVPNVMHSLENFCIKYCKKQPLIVGPGIKTGLNIKYDN
                     PKQVGADRIVNAVAGIEKYGAPSILVDFGTATTFCAISEKGEYLGGTIAPGIKISSEA
                     LFQSASKLPRVELAKPGMTICKSTVSAMQSGIIYGYVGLVDKIISMMKKELNCDDVKV
                     IATGGLAKLIASETKSIDYVDGFLTLEGLRIIYEKNQE"
     gene            3728..4696
                     /gene="dusB"
                     /locus_tag="KRO40_003242"
     CDS             3728..4696
                     /gene="dusB"
                     /locus_tag="KRO40_003242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HBH2094040.1"
                     /translation="MKIGNLELKNKVFLSPMAGVTDLPFRLICKEQGCGLLYTEMING
                     KALCYDDENTKKMLKIEEEEHPVAVQIFGSEPEFMGRAAEIMNDYSNEILDINMGCPA
                     PKVVKNGDGSALMKNPKLAEEVLRAVVKNSKKPVTLKIRKGWDDNSVNAVEIAKIAED
                     CGISALAIHGRTREQFYTGKADWDIIAEIKKNLSIPVIGNGDVFTIEDSINMLDKTGC
                     DAIMIGRGAQGNPWIFKRINHYMNTGEILPEPTLNEKISTAIKHLKLAVEEHGEYVAV
                     REMRKHIAWYLKGLRNSAKLRDEINKIEDYQEVVSKLEYYMEDSLT"
     gene            4805..5284
                     /gene="greA"
                     /locus_tag="KRO40_003243"
     CDS             4805..5284
                     /gene="greA"
                     /locus_tag="KRO40_003243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HBH2094041.1"
                     /translation="MEENKEFLLTQEGYDKLEEELENLKVVKRKEVAERIKVAISFGD
                     LSENAEYDEAKKEQAQVEERILKLENMVRKAVIIDESKIDLNVVTIGSIVKVKDLEFD
                     EEVEYTIVGSTEADPYDGKISNESPVGKALLGRAAKEVVEVQVPDGVAKFEILEIRR"
     gene            5299..6828
                     /gene="lysS"
                     /locus_tag="KRO40_003244"
     CDS             5299..6828
                     /gene="lysS"
                     /locus_tag="KRO40_003244"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HBH2094042.1"
                     /translation="MKNNQQSNEEAQIQEDLSEVLQVRRDKLKKLQESGRDPFKESRY
                     DRTHYSMDIKDNFDSLEGKTTKIAGRIMSKRIQGKAGFIDIQDQEGRIQSYVRLDAIG
                     EEEYSVFSTYDIGDIVGIEGEIFKTKKGEISVKAKSVVLLCKSLQVLPEKYHGLKDQE
                     LRYRQRYVDLIVNPEVKNAFLIRTKALKALRAYLDDRGFLEVETPILNTIAGGANARP
                     FITNHNTLHIPMYLRIANELYLKRLIVGGFDKVYEMGRMFRNEGMDLKHNPEYTAIEL
                     YQAYADYTDMMEITENVIAHMAEVATGSMIVNYQGTEINFTPPWKRMSMEDCVKEYSG
                     VDFSTINTDEEALEVAREKGIEIKPGMRRGEVINAFFEEFGEDKLIQPTFITHHPVEV
                     SPLSKRNVEDPRRTDRFEAFANKWELANAFSELNDPIDQKGRFIDQLRKRELGDDEAF
                     EMDEDFLKALEVGLPPTGGLGIGIDRVIMLLTNSPSIRDVLLFPTMKPIDNNPNKEEE
                     N"
     gene            7137..7331
                     /locus_tag="KRO40_003245"
     CDS             7137..7331
                     /locus_tag="KRO40_003245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094043.1"
                     /translation="MFQVINFLCLFCVGFLVLDVMIYFCKDAMDIFEGTTNVNKVKSI
                     NVWADRVRANSYSYENKIAK"
BASE COUNT         2975 a          753 c         1510 g         2222 t
ORIGIN      
        1 aaattaatag tattaaaagt atattaataa tgtataatta tttattagaa gaaaataagt
       61 catgaaatta tgtcatatta gaggtgaaat atgagagata aaataataga gattatatta
      121 aataataaat ctgaatttat ttcaggagaa gaattatcaa aacaattagg ggtgtcacgt
      181 gcagctatat ggaaacatat gaaagcctta aaagaagagg gatataatat agaatctgta
      241 aataaaaaag ggtatcgatt agcggaaaat ccaactgatt tattaagccc acagaatatt
      301 tactataaat tagatacaga gtttattgga aaaaatattg aacatcttga cactatagat
      361 tcaacaaatg aacatgctaa aaggatagct ataaatagtg tagatgggac tgtgatttta
      421 agtgaacatc aagacatggg gaaaggacga ttgggaagaa gatgggattc aaaacctcat
      481 gaaggaatct ggatgagtat tatattaaaa ccaaatatgg aaccattcaa agctccattt
      541 ataactttaa tagcaggagc aagtgtaacg aaagctttaa acaatctagg agcaaataca
      601 ttaataaaat ggccaaatga tgttatttta aatggaaaaa aaatatgtgg tatattaaca
      661 gagttatctg ctgaaattga aagaacaaat tatgttgttc ttggaattgg aataaatgtt
      721 aaaataatgg attttgaaca agaaatagct gacaaagcca catcattgta taaagaaggg
      781 tatatgttat ccagagtaga tattgttagg aatgtattga ctgaatttga aaaattatat
      841 ttagattata ctgtaaataa ttccaaagaa aaaaccttaa aaatatgtag agattattct
      901 gcaattatag ataaaaatat atatgtatta aaaggagata atagagaact agtgaaatgt
      961 ttagacataa atgaagaggg aaatttatta gttcaaagaa gtgatggaag tataaaagaa
     1021 attatttcag gtgaagtttc tataagagga gaaaaaggat atgtataata atattttgga
     1081 tatagaaggc ttaaaggttg ggcaggttga ggatagaaat ggtcttactg ggtgcacagt
     1141 agtaatatgt gaagaaggag ctacttgcgg tgttgatgta aggggctctg ctccagggac
     1201 tagagaaacc gatttattag accctgtaaa tatggttcaa aaagttcatg cagtagtttt
     1261 ggctggaggt tctgcatatg gtcttgaatc cacttgtggt gtaagtagat acttagaaga
     1321 aaaaggaatt ggttttgatg taggtgtagg taaagtgcct atagttgtag gagcagtttt
     1381 atttgattta ggagtaggga gctttaaatg tagaccagat ttaaagatgg gttatagagc
     1441 ttgtgaagtt gcaaatactg atattttaaa tcaaggaaat tatggagcag gttgtggagc
     1501 cactgttgga aagataagag gtcaggaata tgctatgaaa ggcggaatag gtagctattc
     1561 tataaaatta gataatggtc tagttgtatc tgcattaatt gctgtaaatg ctcttggaga
     1621 tgtttatgaa aatggtaagg ttatagctgg tgctttaaat gataaaaaga cagaaacaat
     1681 tgatacatat aaattaatga aacaaggtga aagtaaaggt ggatttagtg tagataatac
     1741 tacaattggg ataattgcaa caaatgctaa gttaaccaaa gctggatgta aaaagatatc
     1801 tcaaatggga catgatggat atgctaagtc tatttttcct atccatacac ctcatgatgg
     1861 agatacaata ttcacaatat caacaggaga aatagaagca gatataacat tagtaggttc
     1921 attggctgta gaggttgtgg aaaaaagtat aataaatgca gtaaaaaaag cggatagtgt
     1981 agaaaatata atggcatata aagatatagt aaaaaaacga gaaatatgat gaaattagca
     2041 tatttttctt gtcaaattgt tgacaatggc aactcatctt gataaaatta ttcttgttag
     2101 agcgggcatc ctacaatggt agcttgactc ataattataa gaaaaaaacg aaaaaattaa
     2161 aaaattaagt agtccggcat cttaatgagc tggaacggag gtgtattttt tatgatgaac
     2221 acaagtgcat cagtaagaaa agtaaatgta agaaagatga ctataatagg agtactatca
     2281 gctatttcta ttatgctatc tatgactcca ttgggattta ttccagttgg acctacaaaa
     2341 gcaactataa tgcacatacc agttattatt ggagctatta tggaaggacc aatagttggg
     2401 gcagcaatag gatttatatt tgggatatca agtctcttaa atgctataac aaacccaaca
     2461 gtaacatctt ttgtttttat aaatccatta gtttcaatat taccaagagt tatgataggt
     2521 gtattagctt attatgtata tcagttaata attaaggcta caaataaggt atacatatca
     2581 ggtttaatta caggggcaat aggttctctg ttaaatacag ctggagtttt aggaatgata
     2641 tatgtcttat atgctgacaa gtatcttcat gcaatgggta aaagtggttc agcaggaaaa
     2701 gtaataatgg ctcttgccgc agcaaatggg gtgccagaag caatagtagg ggctttagta
     2761 gtagctgctg ttgccactgt acttaagaaa agcaaaaaat agaaagaagg ttaatgacat
     2821 atgcttctag tatttgatgt tggaaatact aatatggttt taggtatata taaaggtgat
     2881 aaattagtta attactggag aattaaaaca gatagggaaa aaacgtctga tgaatatgga
     2941 atcctgataa gtaacctatt tgattatgat aatgtgaata taagtgatat tgatgatgtt
     3001 ataatatcat ctgtagttcc gaatgttatg cattctcttg aaaacttttg tataaagtac
     3061 tgtaaaaaac agccattaat agtaggtcca ggcataaaaa caggtctaaa tataaaatat
     3121 gataatccaa aacaagttgg ggcagataga atagttaatg ctgtagcagg gatagaaaag
     3181 tatggagcac caagtatact tgttgatttt ggaacagcaa ctacattttg tgctatctct
     3241 gaaaaaggtg aatatttggg tggaacaata gcaccaggaa taaaaatatc tagtgaggcg
     3301 ttatttcaaa gtgcgtctaa attacctaga gtagaattag ctaagccagg tatgactatt
     3361 tgtaagagta ctgtatcagc catgcaatct ggaataattt atggatatgt tggtttagtt
     3421 gacaaaataa taagtatgat gaagaaagaa ttgaattgtg atgatgttaa ggttatagct
     3481 acaggtggat tagctaaact gattgcttca gagacgaaaa gtatagatta tgtagatggt
     3541 tttttaacac tagaaggatt gagaataata tatgaaaaaa accaagaata attaatatac
     3601 agggaattgg gttatatatc caattccctt tttatgatag atttctagct atatgtggta
     3661 tattataatg aggaaataag aatttaaagt taaatcacaa aataaaggca aaaataggag
     3721 aaaaacaatg aaaataggaa atttagaatt gaaaaataaa gtttttctat cacctatggc
     3781 aggtgtaaca gaccttccat ttagattaat ttgtaaagaa cagggatgtg ggcttttata
     3841 tacagaaatg ataaatggta aggcactttg ctatgatgat gaaaatacta aaaaaatgct
     3901 taagatagaa gaggaagaac atcctgtagc agttcagata ttcggttcag aaccagagtt
     3961 tatgggaaga gcagcagaga taatgaatga ttattcaaat gagattctcg atataaatat
     4021 ggggtgtcca gctccaaaag tagttaaaaa tggagatggc tcagcactta tgaaaaatcc
     4081 taagcttgca gaagaggtat tgagggcagt agtgaagaac tcaaaaaagc cagtgacttt
     4141 aaagattcga aaaggctggg atgataatag tgtaaatgct gttgaaatag caaagatagc
     4201 agaggattgt ggaataagtg ctttagcaat acatggaaga actagagaac agttttatac
     4261 aggcaaagca gactgggata taattgcaga gattaagaaa aatttgagta tacctgttat
     4321 aggaaatggt gatgtattta caatagaaga ttcaataaat atgttagaca aaactggttg
     4381 tgatgctata atgataggta ggggtgctca aggtaaccct tggatattta aaagaataaa
     4441 ccattatatg aatacaggcg agattttgcc agagccaact cttaacgaaa aaataagtac
     4501 tgccattaag catttaaaac ttgcagtaga agaacatgga gagtatgtag ctgtaaggga
     4561 aatgagaaaa cacatcgctt ggtatttaaa aggacttaga aactctgcaa aattaaggga
     4621 tgaaattaac aaaatagaag actatcaaga agttgtgtcg aaattggagt actatatgga
     4681 agactccttg acataaaaat aatagtgact tataatatag cgcataaatt aaaaaaagat
     4741 tataaaattt ttaaaatata attaggaaaa ttcctaagaa atttgtgaag gagttgtatt
     4801 tataatggaa gaaaataaag agtttttatt gacacaagag ggatatgata aattagaaga
     4861 agaattagaa aacttaaagg ttgtaaagag aaaagaagtt gcagagagaa taaaagttgc
     4921 tatatctttt ggtgatttat ctgaaaatgc tgagtatgat gaagctaaaa aggaacaagc
     4981 acaagttgaa gaaagaattt taaaattaga aaatatggtt agaaaagctg ttatcataga
     5041 tgaaagcaaa atagacctta atgttgttac aataggatca atagttaaag ttaaggattt
     5101 agaatttgat gaagaggttg aatatactat agttggttcg acagaagcag acccatatga
     5161 tggtaaaata tcaaacgaat ctcctgtagg gaaagcactt ttaggtagag ctgcgaaaga
     5221 agttgtggaa gtgcaagttc ctgatggagt tgctaagttt gaaatattag aaataagaag
     5281 ataatttgga ggaaaaaaat gaaaaataat caacaaagca atgaagaagc gcaaattcaa
     5341 gaagacctta gtgaagtact tcaagtaaga agagataaac taaaaaaatt acaagagtca
     5401 ggtagagatc cttttaaaga aagtagatat gatagaactc attattctat ggatataaaa
     5461 gataactttg attctcttga aggtaaaact acaaaaatag caggacgtat aatgagcaag
     5521 agaatacaag gaaaagctgg ctttatagat attcaagacc aagagggaag aatccaatct
     5581 tatgtaagac tagatgctat aggagaggaa gaatatagtg tattttcaac atatgatatt
     5641 ggagatatag ttggaattga aggagaaatc tttaaaacta aaaaaggtga aatatctgta
     5701 aaggctaaat ctgtagtatt actatgtaaa tctttacaag ttttaccaga aaaatatcat
     5761 ggattaaaag accaagaact aagatataga caaagatatg ttgacttaat agtaaatcca
     5821 gaagtaaaaa atgctttttt aattagaaca aaagcattaa aagcattaag agcatactta
     5881 gatgatagag gatttttaga agttgagact ccaatattaa atactatagc aggtggggca
     5941 aatgctagac catttataac taatcataat actttacata taccaatgta tttaagaata
     6001 gcgaatgaat tgtatttaaa aagacttatt gttggtggat ttgataaagt ttatgaaatg
     6061 ggaagaatgt ttagaaatga aggtatggat ttaaaacata atcctgaata tactgcaata
     6121 gaattatatc aagcatatgc agactatact gatatgatgg aaataacaga aaatgttatt
     6181 gcacatatgg ctgaagttgc tacaggaagt atgatagtta actatcaagg aacagaaata
     6241 aactttacac caccttggaa aagaatgagt atggaagatt gtgttaaaga atattctggt
     6301 gtagattttt ctactataaa tacagatgaa gaggcactag aagttgctag agaaaaaggt
     6361 atagagataa aacctggaat gagaagagga gaagtaataa atgctttctt tgaagaattt
     6421 ggagaagata aattaatcca accaacattt ataactcacc atccagttga agtatctcca
     6481 ttatctaaga gaaatgttga agacccaaga agaactgata gatttgaggc atttgctaat
     6541 aagtgggagt tagctaatgc attttctgaa cttaatgacc ctattgacca aaaaggaaga
     6601 tttatagacc aattgagaaa aagagaatta ggtgatgatg aagcttttga aatggatgaa
     6661 gatttcttaa aagcattaga ggtaggtcta cctcctacag gaggactagg aataggtata
     6721 gatagagtaa ttatgttatt aactaactct ccatctataa gagatgtatt attattcccg
     6781 actatgaaac ctattgataa caatccaaat aaagaagaag aaaactaaga aatattagca
     6841 ttctactaag ttttaaataa agtttagcta ttaaattatc aataaatagc taaattttat
     6901 ttaaaatgtc agtgtggaat gctttttata tgcttcaaag attcttttag atatttaatt
     6961 tataaattac caacaaacgt tagaaattga tattagtttt tgttgattga gactttatat
     7021 ttagaaaata tgattgaaag taatttatta tgaaaatatt tagaataatt tatgagaagg
     7081 taaaaagaat aatttatgag aatactatat ataaaaaatt attgggggaa tgtctgatgt
     7141 ttcaagtaat taatttttta tgtttatttt gtgttggatt tttggttctt gatgttatga
     7201 tatatttttg taaggatgca atggatattt ttgagggtac aactaatgtt aataaagtta
     7261 agagtataaa tgtttgggca gatagagtga gagctaattc atattcttat gaaaataaaa
     7321 ttgcaaaata ggtaaaatta tatatgcatg tattgtttgt aatatcaagg gttatatcta
     7381 ttagttttaa ttatatttat taaaaaaacc aaaagttata acctttttta aaataaaaaa
     7441 caaaaaaagt attgacgaaa
//
LOCUS       DAEQCW010000141         7451 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.142, whole genome shotgun sequence.
ACCESSION   DAEQCW010000141 DAEQCW010000000
VERSION     DAEQCW010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7451)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7451)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7451
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.142"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            189..1670
                     /locus_tag="KRO40_003246"
     CDS             189..1670
                     /locus_tag="KRO40_003246"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HBH2094044.1"
                     /translation="MNVRVRFAPSPTGFVHIGSLRTALYNYLFAKKMGGEYILRVEDT
                     DQSRLVEGAIENMLNAMKWAGVNHSEGVILDDSGKVVQKGEYGPYIQSQRLDIYQEYI
                     KQLLDSGKAYYCFCTKERLDEVRDAQRAAGETAKYDGHCKNLSKEEVEANIKAGIPYV
                     IRLRLPENHTIKFTDLVRGDMEFNTNDLDDQVLMKTDGFPTYHFAVVVDDYLMKITHV
                     IRGEEWVSSTPKHVYLYEAFGWEAPVFVHLPNILNKEKKKLSKRQGDVAVEDFKKKGY
                     LPEGLVNYVALVGWSPEDNQELFTMEELEKAFSVERVSKSGGVFDTEKLNWVNQHYIK
                     DGDDAYLTDLAIPFLIEDGFITEEEATNKYDFLKSMISVLKEKLQYVKEVTEHASIFF
                     GDKIEVETEEGREFLRLEHIPTLIDALREKIEKTEVLNAEFVQAMLKEIQKEYKIKGK
                     NLFMGSRIILTGQMHGPDLPKVMEVLGKETCLNRIAYVKNNIL"
     gene            1891..2046
                     /locus_tag="KRO40_003247"
     CDS             1891..2046
                     /locus_tag="KRO40_003247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094045.1"
                     /translation="MYSNIDDVKKELKELCLEYVTILEKLKDEKMITEETFEKCSSQK
                     KIFLEEQ"
     gene            2194..3591
                     /locus_tag="KRO40_003248"
     CDS             2194..3591
                     /locus_tag="KRO40_003248"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HBH2094046.1"
                     /translation="MKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFI
                     IFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRSHEEGISPEEVAAKYIKEYFVDCDGL
                     GIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQKQED
                     LEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGET
                     IDIHAGGQDLTFPHHENEIAQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVR
                     DISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERLYNTKEKLEFTLSNLVES
                     PLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAK
                     KCLDEFNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMG
                     IVLEDTRQGVKWKRI"
     gene            3576..3989
                     /locus_tag="KRO40_003249"
     CDS             3576..3989
                     /locus_tag="KRO40_003249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HBH2094047.1"
                     /translation="MEKDIKMEKTELVTMSPLVLAYLGDTVYETYIREYLIRQNTQRK
                     VNDLHKLAIKYVKAKAQATIIHEIEIELTEEESKIYKRGRNQKSNTSPKNADIIDYKH
                     ATGFEALVGYLYLNNEIERLQYIINKGIKIIERDM"
     gene            4095..4853
                     /locus_tag="KRO40_003250"
     CDS             4095..4853
                     /locus_tag="KRO40_003250"
                     /EC_number="2.1.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent thymidylate synthase"
                     /protein_id="HBH2094048.1"
                     /translation="MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKF
                     LNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRHRIASFSQQSQRYVKLEQFEYII
                     PPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
                     IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPI
                     LFKKTGPSCVNGSCPEGTMTCGDIVQVREKFKAL"
     gene            4866..5603
                     /gene="rlmB"
                     /locus_tag="KRO40_003251"
     CDS             4866..5603
                     /gene="rlmB"
                     /locus_tag="KRO40_003251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HBH2094049.1"
                     /translation="MASIEGRNPVIEAIKSDREIDKILIANSAKEGSIKKIIGMAKDK
                     NIIIQYVDKHKLDEVSTSHSHQGVIAYASEYKYYELDELIDLAKNKDEDPFFIILDEI
                     TDPHNLGSIIRTADAVGAHGVIIPKRRSVHITPVVAKASAGAVEYMPVCKVTNIVNTI
                     KRLKEEGLWIAAADMDGETFYKQNLTGPLGVVIGSEGFGISRLVKQNCDFIVKMPMIG
                     NVTSLNASVAGGILLYEIFRQRLDKSK"
     gene            5606..6133
                     /locus_tag="KRO40_003252"
     CDS             5606..6133
                     /locus_tag="KRO40_003252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NYN domain-containing protein"
                     /protein_id="HBH2094050.1"
                     /translation="MKKNINHYLIIDGYNIINAWDNLKELAKEDLEDSREKLIDDIIE
                     FSEFMGYKTIIVFDAYNVKNSREKVEKRKHITIVYTREHQTADSYIEKFITSLSKYDD
                     VKVATNDYAEQQMILGKGATRMSARELKLELDRSKNKMKEKNIGLRKKIQRNWLEERL
                     DKETLSKLENIRRKR"
     gene            6198..6845
                     /gene="sigH"
                     /locus_tag="KRO40_003253"
     CDS             6198..6845
                     /gene="sigH"
                     /locus_tag="KRO40_003253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigH"
                     /protein_id="HBH2094051.1"
                     /translation="MLVAKEKSYELVDNCQQDEYNIVLRASEGDKIALEYIITKYRNF
                     VKAKAKSYFLIGADKEDIIQEGMIGLYKAVRDFDGSKTNSFKCFAEICITRQIITAIK
                     TATRQKHIPLNSYVSLNKPIYDEESDRTLLDIIATSIVTDPEELIISKEELKNIESKM
                     NELLSDLELEVLELYLNGKSYQFIADKLKRDVKSIDNALQRVKRKLEKHLENRND"
     gene            6919..>7451
                     /locus_tag="KRO40_003254"
     CDS             6919..>7451
                     /locus_tag="KRO40_003254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-binding protein"
                     /protein_id="HBH2094052.1"
                     /translation="MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGE
                     AVDFANIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDG
                     AILVCSATDGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLT
                     EYDFPGDDTPIVRGSAL"
BASE COUNT         3133 a          755 c         1443 g         2120 t
ORIGIN      
        1 ttttagaaaa taaatgactt aaaagaaaga tttatgaaat taaaactagg attttctgat
       61 ataataaaca tgtgtatttt taaataaaaa ggatattatt attagatttg attaaaaata
      121 aacttgcaaa acaatgtact agtttaatat tatagttata ttgaataaaa tatcaggagg
      181 aagtaaaaat gaatgtaaga gtaaggtttg caccaagtcc aacaggattt gtacatatag
      241 gtagtttgag aactgcttta tataactatt tatttgcaaa aaaaatgggc ggagaatata
      301 tattaagagt ggaagataca gaccaaagta gattagtaga aggtgctata gagaatatgc
      361 ttaatgctat gaaatgggct ggggtcaacc atagtgaagg tgttatatta gatgatagtg
      421 gaaaagtagt acaaaaagga gaatatggtc catatattca atctcaaaga ttagatatat
      481 accaagaata tataaagcaa cttttagata gtggaaaagc ttattactgt ttctgtacaa
      541 aagaaagact ggatgaagta agagatgctc aaagagcagc aggagaaaca gctaaatatg
      601 atggtcattg taagaatctt tctaaagaag aagtagaagc gaatataaaa gcaggaatac
      661 catatgttat aagattaaga ttgccagaga atcatacaat taagtttaca gacttagtta
      721 gaggagatat ggaatttaat actaatgact tagatgacca agtattaatg aaaacagatg
      781 gatttccaac ttatcatttt gcagtagttg ttgatgacta tttgatgaaa attacacatg
      841 ttataagagg agaagaatgg gtatcatcta ctccaaaaca tgtttattta tatgaagctt
      901 ttggatggga agcacctgta tttgtgcatt taccaaatat acttaataaa gaaaagaaaa
      961 aattaagtaa aagacaaggt gatgtagctg ttgaagactt taagaaaaaa ggatatttac
     1021 cagagggatt agtaaactat gtagcattag ttggttggtc tcctgaagat aatcaagaat
     1081 tgtttacaat ggaggaatta gaaaaagcct tctctgtaga aagagtatct aaaagtggtg
     1141 gagtatttga tactgaaaaa ttaaattggg ttaatcagca ctatataaaa gatggtgatg
     1201 atgcttatct aacagactta gcaataccat ttttaataga agatggattt ataacagaag
     1261 aagaagctac taataaatat gatttcttaa agagtatgat atcagtactt aaagagaaat
     1321 tacaatatgt aaaagaagtt actgaacatg caagtatatt ttttggagat aaaatagagg
     1381 tagaaactga agagggaaga gagttcttaa gattagaaca tatacctact ttaatagatg
     1441 ctttgagaga aaaaatagaa aaaacagagg tattaaatgc tgagtttgtt caagctatgc
     1501 ttaaagaaat acaaaaagag tacaaaataa aagggaaaaa tttatttatg ggctcaagaa
     1561 taattttgac agggcaaatg catggtccag atttaccaaa agtaatggag gttttaggaa
     1621 aagaaacttg cttaaataga atagcttatg taaaaaataa tatattatag tcataaaagt
     1681 ccgctaattt agaagcggac tttttttgtg ttagtatttg gtgaaaatat ctgcttaaga
     1741 aaatgaaggt atttaaggta ataaatttaa tatataaaaa gcaaagcaaa aatataaata
     1801 aaatatgaat aataaactaa taaaatatta agcatagaag aagggaatct attattttag
     1861 tttgatttaa ttattaaggg ggtaattact atgtatagta atattgatga tgttaaaaag
     1921 gaattaaagg agctatgctt agaatatgtt acaattttag aaaaattaaa agatgaaaaa
     1981 atgattacag aagaaacttt tgaaaagtgc tcttctcaaa aaaaaatatt tttagaagaa
     2041 caatagagga tggtaatagt attattatta ttatgtagtt tgaaagatag tacgaaaaat
     2101 gatagtaata ctattattta ttgcaatttt caactataat ataatatata atgttaagaa
     2161 gataatttat aaaaatacag tgaggtgatg agtgtgaaag tttataatac attgactaga
     2221 acaaaagaag aatttgttcc attagaagaa ggaaaggtaa aaatgtatgt gtgtggtcca
     2281 acagtttata actatataca cataggtaat gcaagaccat ttataatatt tgatactcta
     2341 agaaggtatt tagagtatag aggatatgat gtaacttatg tacaaaactt tacagatgtt
     2401 gatgataaga ttataaatag aagtcatgag gagggaatat ctcctgaaga agttgcggct
     2461 aagtatataa aagaatattt tgtagactgt gatgggctag gaataaaaag agctactgtt
     2521 catcctcagg ttacagataa tatacaacag attatagagt ttataaaaga gttggaagat
     2581 aagggatatg catatgcagt aaatggtgat gtatattttg atacaaataa gtttgaaggt
     2641 tatggaaaac tttcaggtca aaaacaagaa gatttagagg caggggctag aattgaggtt
     2701 aatgaccaaa aaagacatcc tatggacttt gttctttgga aggcaaaaaa agaaggtgag
     2761 ccaggatggg atagcccttg gggagaaggt agaccaggat ggcatataga atgttctgtt
     2821 atgtctaaga gatatttagg tgaaacaatt gatatacatg caggtgggca agatttaaca
     2881 ttcccacatc atgaaaatga aatagctcaa agtgaagcta gaagtggaaa aacattctca
     2941 aaatactgga tgcataatgg atatataaat ataaatgatg aaaagatgag taaatcaaaa
     3001 ggtaatttct ttacagtaag agatatatca aaattatatg atttagagat agtaagattt
     3061 ttcatgttat cagcacatta tagaaatcca gtaaacttta gtgatgagat gttaaatcaa
     3121 gctaaagcag gtcttgaaag actatataat actaaagaaa aattagaatt tacgctaagt
     3181 aatttagtag aatctccttt aacagaaaaa gaagtagagc ttgttaaaga attagatgac
     3241 tttagacaaa aattcataga tgctatggat gatgatgtta atacagcaga cgcagtaagt
     3301 gtaatatttg aattagctaa gttaataaat tctaatgtag atgaaaattc ttctttggag
     3361 tttgctaaaa aatgcttaga tgaatttaat gaacttacag gagtattaaa tattgtaaat
     3421 aagaaaaagg atactgtatt agataaagac attgaagaat tgatacaaaa aagaactgat
     3481 gcaaagaaaa ataaagagtt tcaattagct gatgatatta gacaacaatt actagatatg
     3541 ggaattgtat tagaagacac aagacaaggt gttaagtgga aaaggatata aaaatggaaa
     3601 aaactgaatt agttactatg tcaccattag ttttagcata cttaggtgat acagtgtatg
     3661 agacatatat aagagaatat ttaattagac agaatacaca aagaaaagtt aatgatttgc
     3721 ataaactagc tataaagtat gtaaaagcta aagctcaggc aactataatt catgaaattg
     3781 aaattgagtt aactgaagaa gagagtaaaa tttataaaag gggaagaaat caaaagtcaa
     3841 atacttctcc taagaatgca gatattatag actacaaaca tgcaactggg tttgaggcat
     3901 tagttggata tttgtattta aataatgaaa tagagagact tcaatatatt atcaataaag
     3961 gaatcaaaat tattgaaaga gatatgtaaa tattaaagag tgttgtctta ataataagta
     4021 ataaggcaac acttttttta taactaatgt ataataaata tatagaaatt agtaatgaga
     4081 aaggataaaa agttatgaaa gtaaaattaa tatcacatac acctgaacca gaaaaagtaa
     4141 tagctatggc agctaagcta tgttattcac cagttgggac agacgaaata gaaaaagact
     4201 taacagatga aagtatagag aaatttttaa atatgttatt aagtataggt catgggtcaa
     4261 tattagaaca tgcttcattt acattttcaa tagaaggtat ttcaagggct tgttcacatc
     4321 aaattgttag acatcgtata gctagttttt cacaacaaag tcaaagatat gttaaattag
     4381 aacaatttga gtacataatt cctccagaaa tagaaaaaat agaaaaggca aaagagttat
     4441 ttatagactc catgaaaaaa gaccaagaga attatgataa gttagttgaa atattgtttg
     4501 aaaatcatta taatgaccta ataaaaaacg gtaaaaatga gaaaacagct aaaagacaag
     4561 ctgaaaagaa agcaatagaa gatgctagat acgtatttcc aaatgcatgt gaaacaaaaa
     4621 tggtatttac tataaatgct agaagtttgt ttaatttctt tgaacataga tgctgtgaaa
     4681 gagcacagtg ggaaataaga aatttagctg tggagatgtt aagagaggtt aaaaaggttg
     4741 ctcctatatt atttaaaaag actggtccaa gttgtgtaaa tggaagttgt ccagaaggaa
     4801 ctatgacttg tggagatata gttcaagtta gagaaaaatt taaggccttg taggaggtga
     4861 ataatttggc gagtatagaa ggaagaaatc cggtaataga agcaataaaa agcgacagag
     4921 aaatagataa aatattaatt gcaaattcag ctaaagaagg ttcaattaag aaaataatag
     4981 gaatggctaa agataagaat ataattattc agtatgttga taaacataag ttagatgaag
     5041 taagtacaag tcattcacat caaggtgtaa tagcttatgc aagtgagtat aagtattatg
     5101 aattagatga gctaatagat ttagcaaaga ataaagatga agacccattt ttcattatat
     5161 tagatgagat aacagaccca cataatttgg gttcaataat aaggacagca gatgcagtag
     5221 gagcacatgg agttatcatt ccaaaaagaa ggtctgtaca cataactcct gtagttgcca
     5281 aagcatctgc tggagcagta gaatatatgc cagtttgcaa ggtaaccaat atagttaata
     5341 caataaaaag actcaaagaa gaagggctgt ggattgctgc agctgatatg gatggagaaa
     5401 ctttttataa acaaaatctt actggtcctc ttggtgtagt aattggaagt gaaggttttg
     5461 gaatatctag attggttaaa caaaactgtg actttatagt aaaaatgcca atgataggta
     5521 atgttacatc tttaaatgca tctgtagcag gtggaatact tttatatgag atattcagac
     5581 aaagactgga taaaagtaaa taggcatgaa aaaaaatata aatcattact taataataga
     5641 tggctacaat attataaatg cgtgggacaa tttgaaagaa ctggctaaag aggacttaga
     5701 agattctcga gaaaagctta ttgatgacat tatagaattt tctgagttta tgggttataa
     5761 gactataata gtttttgatg cttataatgt taaaaattct cgagaaaaag ttgaaaaaag
     5821 aaaacacata acaatagttt atacaagaga acaccaaaca gcagatagtt atatagagaa
     5881 atttataact tctttatcaa agtatgatga tgtaaaagta gccactaatg actatgcaga
     5941 acagcaaatg attttaggaa aaggtgctac tagaatgtct gcaagagaat taaagttaga
     6001 gttagatcgt tccaagaata aaatgaagga aaaaaatatc ggtttgagga aaaaaattca
     6061 gcgaaattgg ttggaggaaa ggttagataa agaaacattg tcgaaacttg agaacattcg
     6121 tagaaagcgt tgaaattact aggttcttta gactataata tacctataaa tttgttttat
     6181 atatggggga gatttacatg ttggtagcaa aagaaaaaag ttatgagtta gtggacaatt
     6241 gtcagcagga tgagtataac attgtattaa gagcaagtga aggggataaa atagcactag
     6301 agtacattat tactaaatac agaaattttg taaaggcaaa agcaaagtca tattttttaa
     6361 ttggagcaga taaagaagat ataatacaag aaggaatgat aggcctttat aaggcagtta
     6421 gagattttga tggaagtaag accaattcat ttaaatgttt tgcggagata tgtataacaa
     6481 gacaaataat aactgctata aaaactgcaa caagacaaaa acatatacct ttaaattcat
     6541 atgtttcttt gaataaacca atatatgatg aagagtcaga cagaacactt ttagatatta
     6601 tagctacaag tatagtaaca gatccagaag agcttataat tagtaaagaa gagttaaaaa
     6661 atatagaatc aaaaatgaac gaattgttaa gtgacttgga attagaagta ctagaattat
     6721 atttaaatgg aaagtcatac cagtttatag cggacaagct taaaagagat gtaaagtcaa
     6781 tagataacgc tttacaaagg gttaagagaa aattagaaaa acatcttgaa aacagaaatg
     6841 attaatagta aaatacttac cataagctta ttgtgagcaa aattaattta tatcgaaaga
     6901 taagggagga aattcaaaat ggctaaagct aaatacgaaa gaacaaaacc tcatgttaat
     6961 atagggacaa taggacacgt agaccacggt aaaactacat taacagcagc aataacaaaa
     7021 acattatatg acagatatca attaggagaa gcagtagatt tcgcaaacat agataaagct
     7081 ccagaagaaa gagaaagagg aatcacaata tcaacagcac acgttgagta tgaaacacca
     7141 aatagacact atgcacacgt tgactgccca ggacatgctg actacgttaa gaacatgata
     7201 acaggagcag cacaaatgga cggagcaata ttagtttgtt cagcaacaga tggaccaatg
     7261 ccacaaacaa gagagcatat actattatca agacaagttg gagtaccata tatagtagta
     7321 ttcttaaaca aatgtgacat ggtagatgat gaagagttat tagagttagt agagatggaa
     7381 gtaagagatt tattaacaga atatgatttc ccaggagatg acactccaat agtaagaggt
     7441 tcagcattaa t
//
LOCUS       DAEQCW010000142         7351 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.143, whole genome shotgun sequence.
ACCESSION   DAEQCW010000142 DAEQCW010000000
VERSION     DAEQCW010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7351)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7351)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7351
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.143"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(22..684)
                     /locus_tag="KRO40_003255"
                     /pseudo
     CDS             complement(22..684)
                     /locus_tag="KRO40_003255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440163.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
     gene            complement(844..1380)
                     /locus_tag="KRO40_003256"
     CDS             complement(844..1380)
                     /locus_tag="KRO40_003256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBH2094053.1"
                     /translation="MIGLKCGMVKLLEHQMIWDKSAKDVIILLKSIWDKTAIDIQHIG
                     STSIPSISAKPIIDIVVGVASLEEAKLYLERLEQCGIVFRGQDVPKQLLFAMGDFEKN
                     TRTHHIHVVEWNSVAWNNYINFRDYLNTFTDKAKLYDSHKQKLALQFEDNRKIYTQRK
                     QELINILLEEARLWRINT"
     gene            complement(1453..1866)
                     /locus_tag="KRO40_003257"
     CDS             complement(1453..1866)
                     /locus_tag="KRO40_003257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003507530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH2094054.1"
                     /translation="MKMPKESIDTIMFAPCGMNCMVCYKHCYHKKPCAGCLNGDTGKP
                     EHCRKCKIKDCVCQKGLFYCFECFNFPCKLIKNLEKSYNKRYQASLMENSKFVQQYGL
                     EKFMQKQKERYTCSKCGGIISIHDRECSECQEKVK"
     gene            2359..2997
                     /locus_tag="KRO40_003258"
     CDS             2359..2997
                     /locus_tag="KRO40_003258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="HBH2094055.1"
                     /translation="MDEKILELLQEMQGNISNMQGSISGIEGTISDMQSNINGIEGTI
                     SDMQSNINGIEGTISSMQGNINGIENTISGMQGTIGDMQGSISGMNGTISDMQGSISS
                     MDGTINSMQGSITDMQVEIKEVNSRLDNMEPDIKDLKTGQVETSSRLDTIQSDVTEIK
                     SDVKINRNTLDTVIKHTSSLVKDTSDIKNDLNNIEIVTSKNSNDIAKLKSVK"
     gene            complement(3605..3784)
                     /locus_tag="KRO40_003259"
     CDS             complement(3605..3784)
                     /locus_tag="KRO40_003259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2094056.1"
                     /translation="MLQTGKQGADKKYLDNMFFVKGYVEELLFLDKSYDIVFSCIVFH
                     HCTNVQNIFCIFWKW"
     gene            complement(4010..4543)
                     /locus_tag="KRO40_003260"
     CDS             complement(4010..4543)
                     /locus_tag="KRO40_003260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBH2094057.1"
                     /translation="MQYISYYHSPIGNILLASDNIGLTGLWFENQKYYAYNLDQEHQE
                     KELPIFEQTKKWLDIYFSGKEPNFTPSLHMVGTPFQTTVWKILQQIPYGKTITYGEIA
                     YKVAQQKGISKMSAQAIGGAVGHNGISIIVPCHRVVGTNGSLTGYAGGIDRKIKLLSL
                     EKVSVQHYFIPKKGSAL"
     gene            complement(6086..6658)
                     /locus_tag="KRO40_003261"
     CDS             complement(6086..6658)
                     /locus_tag="KRO40_003261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBH2094058.1"
                     /translation="MWIYQKTLEHPVNIRQADPRMAKYIMTQLGGPNGELAAATRYLQ
                     QRYTMPTGKSRALLTDIGTEEMAHVEIISSVLYQLIGNCTPEELKAAGLGSNYANFGH
                     GLQPVDSNGVNFTTSYINVFGDSVTDLHEDMAAEQKALATYYQLINLTDDPDLKDILR
                     FLGEREVVHYQRFGEALMDVYEFTECKHQF"
     gene            complement(6720..6983)
                     /locus_tag="KRO40_003262"
     CDS             complement(6720..6983)
                     /locus_tag="KRO40_003262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBH2094059.1"
                     /translation="MSLNRRELLERISEYQFACIELNLYLDNNPRDKKALDSYNRYCD
                     KFTQAVCDYESKYGALTNFGYESSEYPWSWISEPWPWDKSFYK"
     gene            complement(6983..7204)
                     /locus_tag="KRO40_003263"
     CDS             complement(6983..7204)
                     /locus_tag="KRO40_003263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBH2094060.1"
                     /translation="MGYLKEDKQDYCCEFARPYINRQIYDDTYNPKTALKRGTLFPEL
                     DLIESNNYNDWLYANPKNRVRAKKGGNMY"
BASE COUNT         2580 a         1248 c          889 g         2634 t
ORIGIN      
        1 agtgttcgta gctatttttt aatcaaactg gaatacagac tccattccta ggaaattggc
       61 tgaaatatag tctgctgtca aagatgctgt catcacagaa attaaaacag atactgaaaa
      121 gtttttatgg acttcttcaa gtgaaaacat aacacccgct agtggtgcat gaaaggctgc
      181 tgataatcca gcacttgccc cacaggttaa caggaatttt tcctctgtct tccctcggtc
      241 aagagctcta gaaatacctt tacctgccat agcaccaagc tgaatggaag gaccttccct
      301 tcccaaagca agaccaccca tgagtgataa gaatcctcca ataaattttg ttggcaacac
      361 tcgccaccat acttgtttta ttttccctgt catttccccc tcaagctgag ggataccact
      421 tccagaaatc attggctccc agtccaccaa ctttgataca atccacgcaa gtactgcaag
      481 tactgcaaac caagctatta tttttattgt agaaccttct acaaatttta aaatttggct
      541 aagccaagta ccagcctgcc ctaaaagtat cctgtataaa agcacaatca aaccagccac
      601 agccccaacc ataagtcctt caccaatcaa aattacctga aagtgctctg cccgtttgat
      661 aatatgagat gtatcctttt tcatactgtt cctccttcat ccaataattc tacacaatct
      721 gaatctccaa tgactaaagt catgagtgtg tacagatatt ttttaatcaa caaaaataga
      781 tttttattta ctaaatataa gaaaataatt gctcaatttc tcaataaatg tgaatttatt
      841 cttttaggta tttattctcc acagtcgtgc ttcttccagc aaaatattta ttagttcttg
      901 ctttctctgt gtatagattt tacgattgtc ctcaaactgt aatgctaatt tttgtttatg
      961 actatcatag agttttgctt tgtctgtaaa agtatttaga taatctcgaa aattgatata
     1021 attattccat gcaacactat tccattcaac aacatgaata tggtgagtac gagtattttt
     1081 ctcaaaatct cccatagcaa aaagtaattg ttttggtaca tcctgacctc gaaaaacgat
     1141 tccacattgc tctaaccttt cgaggtataa tttagcttcc tctaaagaag caacacctac
     1201 aacaatatca ataataggct ttgcgctaat actgggaata gaagtgcttc caatgtgttg
     1261 aatatcaatg gcagtcttat cccatatact tttcaataat ataatgacat cttttgcact
     1321 tttatcccat atcatctgat gttccaataa tttaaccata ccacatttta aacctatcac
     1381 tatataccac ctcaatataa tccaccttta tatatattac aattttttct atcttgataa
     1441 acagtgattt agctatttca ctttttcttg acactcgcta cattccctat catgaataga
     1501 tataattcct ccacatttag aacaagtata tctctccttc tgcttttgca taaacttctc
     1561 taaaccgtac tgctgaacaa atttactatt ttccataagg cttgcttgat atctcttgtt
     1621 ataacttttt tcaagatttt ttatgagttt acaaggaaaa ttgaaacatt caaaacaata
     1681 aaacaaccct ttttgacaga cacaatcctt tattttacac ttacggcagt gttctggctt
     1741 tcctgtatcg ccattcaaac aaccagcaca tggctttttg tgataacaat gcttatagca
     1801 aaccatacaa ttcattccac aaggagcaaa cataatcgta tcaatactct cttttggcat
     1861 tttcataaca ttttactcct ttcaaaaatc caatttgtcg aattgttata tattcatatt
     1921 gtaacataaa aaatagctaa aaaattcatg cactttcatt gccaataaat tttcaaggaa
     1981 atatgaaagt ttaaaactaa gaataaaaag agataaaaag gaagctacta atcaaaatat
     2041 tcaaatacaa gtaatcaata taaataactt aaggtatatt taaaagtata tgatattacc
     2101 agcagtttta aatacaaata taaccacaca tgcctcaaaa acacttatta cagtatctta
     2161 gaaacttaga caatacataa gattcattaa taaaaaagtt ctcaatatag tcattaataa
     2221 aaacgttctc aatatagata tatttaacca tgttttgaat agcagataat tatatgatta
     2281 aaaattaaat atgacatagc gtttgtggaa tataacacct aaattatgtt ataataataa
     2341 aacaggagtg tgatagtgat ggatgaaaaa atattagagt tattacagga aatgcaaggt
     2401 aatattagta atatgcaagg tagtatcagt ggtatcgaag gcactattag cgatatgcaa
     2461 agcaatatca atggtatcga aggcactatt agcgatatgc aaagcaatat caatggtatc
     2521 gaaggcacta ttagtagtat gcaaggcaat atcaatggta tcgaaaacac tattagtggc
     2581 atgcaaggca ctattggcga tatgcaaggt agtatcagtg gtatgaatgg cactattagc
     2641 gatatgcaag gcagtatcag tagtatggat ggcactatta atagtatgca aggcagtatt
     2701 actgatatgc aagttgaaat taaagaagtc aatagtaggt tagacaatat ggaacctgat
     2761 attaaagact taaaaactgg acaagttgaa actagtagta gacttgatac tattcagagt
     2821 gatgttacag aaattaagtc agatgtaaaa attaacagaa atacattaga tacagtgatt
     2881 aaacatacct cttcattagt aaaagataca tcagatatta aaaatgattt aaataatata
     2941 gagatagtca catctaagaa ttcgaatgat attgctaaat taaaatcagt taaataatat
     3001 actatagtaa aaaatacctg aaaatttcac atacttcttt aaagttatac caaattttat
     3061 acagaaatac tgattatccg acaacacact ttacttataa ataatttatt aaaaaaatac
     3121 tcattttatc ctaaaattaa cacgactaaa tgagtcttga tataataata aaaaataagg
     3181 gagattggac actaaaaagt tgtgtatctc ccttatattc tataatatag ttatataatt
     3241 tttcagccta aaataaaagt ccatctttga ttaaaacaca tccccttatc acttataaaa
     3301 ggataaaatc ttgttttcat ttttccattt atatcttctt gcttaagagt aataattttt
     3361 tcttttgata ctttaagtgt ttggttaaat ttaaccaatc gactaagttt tgttcaatat
     3421 ctatttttca tattttccaa tacttaatct attttttata aataattctt tcatttctaa
     3481 ctcacttaca ttttttacat aaaacgaaac atataaattt caaccttatc ttgtatggtt
     3541 cttaatactt aatgagtagc ttaagtatca atcattataa atttttccct tacatttaac
     3601 actcttacca tttccaaaat atacaaaata tattttgaac atttgtacaa tgatgaaata
     3661 caatacatga aaatacaata tcataactct tgtctaaaaa tagaagttct tcaacataac
     3721 ctttcacaaa aaacatatta tctaagtatt ttttgtctgc tccttgtttt cctgtttgta
     3781 gcatataaat tactgcatct aaacatataa ctactcacac gaaaaaagaa aataaacttc
     3841 caaaatacaa gctctaaaaa ctacctctaa agttgtataa tgtttactag gaataaggtt
     3901 gtataacata tagtttaaat aatcattttt taaaattgca agttattgct ttcaaaatta
     3961 gatgttttta tatcaaataa atgattaaga atttctaaat ttaatggctt tataatgcac
     4021 tccctttctt tgggataaaa taatgttgca cagatacttt ttctaaagat aacaatttta
     4081 tttttctatc aattccacca gcatacccag tcaaactccc atttgttcct acaacacgat
     4141 gacatggaac aataatagag attccattat gccctactgc accaccgatt gcttgtgctg
     4201 acattttaga tattcctttt tgttgagcaa ctttatatgc aatttctcca taagtgattg
     4261 ttttaccata tggtatttgt tgtaaaattt tccacactgt agtctgaaaa ggagtaccta
     4321 ccatatggag tgatggtgta aaattgggtt cttttcccga aaaataaata tctaaccatt
     4381 tctttgtctg ctcgaaaatt ggcaattctt tttcttgatg ttcttggtca agattataag
     4441 cataatactt ttgattctca aaccaaagac cagttaaccc aatattatct gatgctaaaa
     4501 gaatatttcc aattggacta tggtaatagc taatatattg catacaattc ctccttatat
     4561 tctgaaaact tcactcaaat cattagacac ttcttttcta tctaccatta tgtaaaaaca
     4621 tactaatata atttccttct aactacactt tcgttataat atctatcctc atatcatatt
     4681 agttttatat ttacctgcat ctgttcatcc ttttttccct ttccctttga tgaatataaa
     4741 attcatacat ttaagcttcc tactgtatta acttttatag aagtgtatat tataatttta
     4801 tcaccaaata gaccaaaaaa atatcgatat aacatcaagt aatatcataa tactttcaaa
     4861 tgggaaaagt aagaataggc tgtaaaaaag aaaagtattt ttatgttaga aatccagtaa
     4921 aatcgttagt agatagaata acagaaaacg aacaatttgc tatttatcat tttacacata
     4981 aatataattg gcgcaataaa gtgttttcta ttctacaacg attaataagg ttagaaaaaa
     5041 gtaaaaatga actgtatatg tatgaagcat tagtttctgt ttctttcctt tggcttatta
     5101 tgataaaaaa tattgttttg ccaccaataa aacacaaaaa tataattaat atccatatgc
     5161 aaaaaatttt acgttatatt gaaaaatact attgttttac attatattga agggtactat
     5221 tgtgaaaact taattttgga gtactatcaa gcagtggtaa tatcaataaa tcagagtgct
     5281 ccagatgatt tgaactaagt ttaaatacta taccttataa atattttact gagttttgtt
     5341 tattaaaagc aactcaattt ctaaaaggca caaatgagct aataagtgac attgctataa
     5401 aagttgtttt tcatcaaata atctatttta gtaaatgttt taaagaaaaa acgggatatt
     5461 ctccaaaagt gtacagaaat ataaaaaaag agatatgatt ttttatttct tttgattatc
     5521 caaagagtaa ataaaaaata ttgtaaaaaa cttactaaca acggcaatgc tttgaactat
     5581 ggtaatactt tgaacttttg attggacttt ttttgctaaa ataatatatt taaatagcaa
     5641 agtaatctgt ttaatcaata aaaaataaga gataaaagaa atcaactaaa acttttacct
     5701 cttattttga tagtttatca gagctaatat ttacactctt tttatttttg atacttcatt
     5761 aaaaatgatg cttattctct tttcattttt aatacttcat tagaacttat gcttattctc
     5821 ttttcacttt taattcttca ttagaactta tgcttactct ccattcactt ttaattcttc
     5881 attaggacta tgcttattct ccattcactt ttaattcttc attaaaaatg atgcttattc
     5941 tccattcact tttaattctt cattaaaaat gatgcttatt ctccattcac ttttgattct
     6001 tcattaaaaa tgatgcttat tctctgttca cttttaattc tttattaaaa ctgatgctta
     6061 ttctccattc actttcaatt cttcattaaa actgatgctt gcactctgta aactcataaa
     6121 catccattaa tgcttcacca aatctttgat agtgaactac ttccctctca cccaaaaatc
     6181 tcaatatatc tttcaaatca gggtcatcag ttaaatttat taattgatag tacgtagcca
     6241 atgctttttg ttcagcagcc atatcctcat gtaaatcagt taccgaatcg ccaaagacat
     6301 taatataact tgtagtaaag tttactccat tagaatctac tggctgaaga ccatgtccaa
     6361 aattagcata attactacca agtccagcag ccttaagttc ttctggagta caattgccta
     6421 ttaattgata taacactgaa gaaattatct caacatgagc catttcctct gtacctatat
     6481 cagttaaaag tgcacgagat tttccagttg gcatagtata tctttgttga agatatctag
     6541 ttgcagctgc caactcacca ttaggtcctc ccaactgagt catgatatat tttgccattc
     6601 tagggtctgc ttgtcttatg ttaactggat gttccagtgt tttttgataa atccacatat
     6661 tatcttactc ctccttaata tatatttaat aataaatcta attttaaagt ttaataattt
     6721 tatttataaa atgatttgtc ccatggccaa ggttcagata tccatgacca aggatattca
     6781 cttgattcat atccaaaatt agttaatgct ccatatttag attcataatc acacacagct
     6841 tgtgtaaatt tatcgcagta tctgttgtat gaatcaagag ctttcttatc ccttggattg
     6901 ttatctaaat ataaatttaa ttctatacag gcaaattgat attctgaaat tctctctaaa
     6961 agttctcttc tatttaatga cattagtaca tgttaccccc ttttttagct ctaactctat
     7021 ttttaggatt tgcatatagc caatcattat agttatttga ctctattaaa tctaattcag
     7081 gaaataaagt acctcttttt aatgctgttt ttggattgta tgtgtcatca taaatttgac
     7141 gattgatgta tggtctagca aattcacaac aatagtcttg tttatcctct tttaaatatc
     7201 ccattaatta tcctccttaa tttttagaat tttaaaatag cattattttt aaaaattgta
     7261 tactggttct atattataac tggtagtttt aataggtctt taataagatt aaatgattaa
     7321 ataagtatct ttttttctta ttttacctct a
//
LOCUS       DAEQCW010000143         7146 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.144, whole genome shotgun sequence.
ACCESSION   DAEQCW010000143 DAEQCW010000000
VERSION     DAEQCW010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7146)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7146)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7146
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.144"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            436..945
                     /locus_tag="KRO40_003264"
     CDS             436..945
                     /locus_tag="KRO40_003264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009528606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HBH2094061.1"
                     /translation="MSKELAINEQIKDKEIRVLSPTGEQLGVMPTKEAQAMANSKNLD
                     LVQISPNANPPVCKIMDYGKFRYEQARKEKEAKKKQKTIVVKEVRLRPGIEQNDLNTK
                     ANNAIKFLKKGDKVKVELRFRGRELGHKDIGKEVMLKFLDIIKEFGEPTKAPAFEGNN
                     MVVIIDPKK"
     gene            973..1167
                     /gene="rpmI"
                     /locus_tag="KRO40_003265"
     CDS             973..1167
                     /gene="rpmI"
                     /locus_tag="KRO40_003265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HBH2094062.1"
                     /translation="MPKMKTHRGAAKRLKKTGTGKLKRAKAFKKHILTKKSAKTKMNL
                     RKSTLVSDGDAKRIAQLLPY"
     gene            1223..1579
                     /gene="rplT"
                     /locus_tag="KRO40_003266"
     CDS             1223..1579
                     /gene="rplT"
                     /locus_tag="KRO40_003266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HBH2094063.1"
                     /translation="MARVKKAMNARKKHKKILKLAKGFRGSRSKLYRPANTFVMKALK
                     NAYIGRKLKKRDFRKLWIQRINAAARMNGISYSRLMNGLKLSGVEVNRKMLSEMAIQD
                     PEGFAKLAEVAKAKLA"
     gene            1889..2434
                     /locus_tag="KRO40_003267"
     CDS             1889..2434
                     /locus_tag="KRO40_003267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094064.1"
                     /translation="MNEKLMDCFVNPIKCKLLIEIFSNNRTTAKQLGEKFQDISKATL
                     YRYLNKMLKDDIIKVVEENKIRGTVEKVYAMKLDIADDVNKIIDENSGEEYAQLFTQY
                     MMGFLREFYEYAERKEKDILKDGSGFSVCPVYASIDEIVEVSKKIASILEPLRNNSHE
                     EGRRMHSIGVIITPPKKDEGK"
     gene            2869..4794
                     /locus_tag="KRO40_003268"
     CDS             2869..4794
                     /locus_tag="KRO40_003268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2094065.1"
                     /translation="MKIKFVIMPLVIFLMVLFVGCQSTKDTEVKAKDTEIKILGTGDL
                     HSILTDSMVSYVNEEREKNKNLLMVDAGDFYGTQSREMWEWSSGKKLINIKRNGRAEY
                     DDIIKSSKDEVPIVKDMAKLKYDAVVLGDNEFVSNDKQSLDKLVSDFKNNNMPLVSAN
                     IYEQSGENYVQPYVMKNIKTDEGNVKVGILGLTIKEVGETLGLEDFEKDKKARELGEQ
                     ADYKGKLYANDLVEDAKKWIKVMEKESPDIIVAVVHSGEEPKTDRNPGNRIKELATTV
                     DGIDAIVAGHTHEKIDEHKYKNKSGDEVIVTQPGWHGDRVSEINFKLNKENGKWDIKE
                     KSSKLKIIDKEVSIVATADLHSHFSDKLTVDLVNERSNPIEPVVVDAGDFLDPQTDEM
                     TQWYKEWKSIRDNNSDKTISRCPMVMDMNQGMYDAVVLGNHEFVSEKDEFWSDERLLD
                     AVIEDFEQVAISVLSANIYRQSGKNYVKPYIIKDVETSEGNVKVGILGLTIKEVGKGL
                     KNVNLQEQFQYKDKLYANDLVEDAKKWVKVMKKKKPDIIVAVVHSGEEPKNPKHPGNR
                     IKELATTVDGIDAIVASHTHEKIDEHEYKNKSGEKVIVTQPGEHGKYYSKITFKVNKE
                     KGSWTINDKFSKTIEVE"
     gene            5195..7099
                     /locus_tag="KRO40_003269"
     CDS             5195..7099
                     /locus_tag="KRO40_003269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2094066.1"
                     /translation="MKIKFIIVASIIFLIVLLVGCQSTKDTEINVLATSDLHSIIPDN
                     LISYVEEERKYDENLLMVDAGDFFDMQSGEMNKWFTGQKLVRFKDGIPEYKKIAEPRE
                     GEVPLAKKMAKLKYDAVTFGNHEFVSNDKQSLDKLVSDFKNNNIPLVSANVYEQSGEN
                     YVKPYVMKNINTDKGTVKVGILGLTIKEVGERSRFKSFEQDKKARELGEQPQYKGKLY
                     ANDLVEDANKWVNVMEKKEKPDIIVAIVHSGEEPKNPKNPGNRIKELATTVEGIDAIV
                     AGHTHEKIEQHTYKNNSGEEVIVTQPGAHGNSISKINFKLDKKNDKWFIKDKYSELKV
                     FGKEVNIITTSGLNPKFSDEMAVNLFNERDRDVQPIFIDTGDFLNTNTKEMTKWAKEW
                     QYNENKGIYKKINEWPIVYLGYDAVVLGSHEFTEDKETFEEKKSTLDYIIENFEEMKI
                     PVLSANIYDESGENYVKPYIIHNVETREGNIKVGVLGLTTTDKDEEDLSNSSLSKDSK
                     TSKIPEETGKLYTNNLVKDASEWVKVMQKESPDVIVAVVHSDNNSTLKNPSSEVKKLA
                     MSVDGIDAIVVGHTKNKVEEHIYKNKSGDEVIVTQSGEDCYSKISLELRKENGKWNII
                     NKYSKAIKMK"
BASE COUNT         3010 a          715 c         1350 g         2071 t
ORIGIN      
        1 atgtagtata gtagtatatt agaatacaat atagaatttg ttgggtagta tagtgttata
       61 ttagaataca atataggatt tgttatgtag aatatataga gtcatgtaga atatacatat
      121 ataaaaggat tttgggtata aatttaaaaa ttaatagcaa aatgagtagt atagacatat
      181 aattagtagt aggaagtaat taaatttttc ctaaacaaaa aaaatagttg caaataattt
      241 gattaagtga tatagtaaat aaggtaagaa taaaacaaag aagaagtccg cttctcacct
      301 tacgccggag gttagtaagg taaatataag ttaaagctta attttaattt aagtttgttt
      361 aaatttggta acttatattg cggatgatta cgtcatccgc tttttatttt ataaaaattt
      421 tggaggtgtc ctacaattag caaagaatta gcaatcaatg aacaaataaa agataaggaa
      481 ataagagtcc tttcaccaac aggtgaacaa cttggagtaa tgcctactaa agaagctcaa
      541 gcaatggcta atagcaaaaa cttagatttg gttcaaatct cgccgaatgc aaatccacca
      601 gtatgtaaga taatggatta tggaaagttt agatatgagc aagcgagaaa agagaaagaa
      661 gctaagaaaa aacaaaaaac tatagttgta aaagaagtaa gacttagacc aggtattgaa
      721 caaaatgatt taaatacgaa agctaataat gctataaagt tccttaaaaa aggggataaa
      781 gtcaaagttg aacttagatt tagaggaaga gaattaggac ataaagacat aggtaaagaa
      841 gttatgctta agtttttaga tataataaaa gagtttggag aaccaacaaa agcccctgca
      901 tttgagggta ataatatggt tgtaattata gatccaaaaa aatagatgat taactgagag
      961 gaggaatttg tcatgcctaa aatgaaaact catagaggtg cagcaaagag attaaagaaa
     1021 acaggaactg gaaagttaaa gagagctaaa gcttttaaaa aacatatatt aactaaaaaa
     1081 tctgcaaaaa ctaaaatgaa cttaagaaaa tcaactttag taagtgatgg agatgctaag
     1141 agaatagcac aattattacc atactaagat acagattgta aataataact atagaagagg
     1201 gatataaaag gaggtcataa cgatggcaag agttaaaaaa gctatgaacg ctcgtaaaaa
     1261 gcataagaaa atattaaaac ttgcaaaagg attcagagga tctagaagca aattatatag
     1321 accagcaaat acattcgtaa tgaaagcatt aaaaaatgct tatataggaa gaaagttaaa
     1381 gaagagagac ttcagaaaac tttggataca aagaataaat gcagctgcta gaatgaatgg
     1441 aatatcttat tcaagattaa tgaatggatt aaaattatct ggtgttgaag ttaacagaaa
     1501 aatgttatct gaaatggcta tacaagaccc agaaggattt gcaaaattag cagaagttgc
     1561 taaagcaaaa ttagcttagt attgaatcat gagatgtaaa gtctttgagt tatataaata
     1621 attcaaggac ttttttattt tttgaaaaat acttattagt gtcatgtaca accaatttta
     1681 taatgataaa taaaataagc aatacaatag aattttatga gatttattat aagaattgtt
     1741 acaattattt atgatagcta taaaaagtca tagtaaaaat gatattgatg tatgttgata
     1801 tatgtataaa gtttccaatc aatcttgaat taatattatc aacatgataa tattatctta
     1861 ttaataatat aaataagggg gacataatat gaatgaaaaa ctaatggatt gttttgtaaa
     1921 cccaattaaa tgcaagttat tgattgaaat tttttcaaat aatcgaacta cagctaaaca
     1981 attaggagaa aaatttcaag atatatcaaa ggcaacactt tatcgttacc ttaataaaat
     2041 gttgaaagat gatattataa aagtggttga agaaaataaa ataaggggaa ctgttgaaaa
     2101 agtatatgct atgaagttag atatagctga tgatgtgaac aaaattatag atgagaactc
     2161 tggagaagaa tatgctcaac tgtttactca atatatgatg ggatttttaa gagaatttta
     2221 tgaatacgct gaaagaaagg aaaaggatat cctaaaagat ggttcaggat tttctgtctg
     2281 tccagtatat gctagtattg atgagatagt tgaagtgagt aaaaaaattg ctagtatact
     2341 agaacctcta agaaataact cacatgaaga aggtagaaga atgcattcta taggagtgat
     2401 aattactcca cctaaaaagg atgaagggaa ataaatctga tttacatggg gtagagccaa
     2461 tttatacagg gaatcgtttt atgatttaca tatgtatcca gagcaaagta tctctgcttg
     2521 gattgtactt cattgtacca tttcatccaa tgacttggag tggtacaatg aagtttttta
     2581 atttttcata ttaatgctaa agaaatgaac tttagaccac atatgcaatt aggttgcatt
     2641 atacaattag accacatata caaaataaaa atcagtattt ttatagcaga taaattgact
     2701 gtcattcttc ttaaaaatca tctattagtt attgttagca tattgaaaga aattatagta
     2761 atctattgaa taaatgaata ttgcctataa tcatataaac tgctatagtt taaaataaag
     2821 caggacgtta aattttatag taatctaaaa atttaagagg gggattttat gaaaataaaa
     2881 tttgttatta tgccattggt gatattttta atggtattat ttgtggggtg tcaaagtaca
     2941 aaagatacag aagttaaagc aaaagataca gaaattaaaa tattagggac aggtgattta
     3001 cattcaattt tgacagactc tatggtttcg tatgtaaatg aggaaaggga aaagaataaa
     3061 aatctgctta tggtagatgc gggagatttc tatggtacac aaagtagaga aatgtgggaa
     3121 tggtcttctg gaaaaaagtt aattaatatt aaaagaaatg gtagagcaga gtatgatgac
     3181 ataattaaga gtagtaaaga tgaagtacct atagttaaag atatggcaaa gttgaaatat
     3241 gatgctgtag ttttgggaga taatgaattt gtttcaaatg ataagcaaag tcttgataaa
     3301 ctggtttctg attttaaaaa taataatatg ccattggtat cagcaaatat atatgaacaa
     3361 tctggagaaa attatgtaca accatatgta atgaaaaata ttaagacaga tgagggcaat
     3421 gtaaaagttg gaatactagg tcttactata aaagaagtag gggaaaccct tggtcttgag
     3481 gattttgaaa aggataaaaa agctagagag cttggagaac aagctgatta caaaggaaaa
     3541 ttatatgcaa atgatttagt agaagatgca aaaaaatgga taaaagttat ggaaaaagaa
     3601 agtccagaca taatagttgc agttgtacac tcaggggaag aacctaaaac agatagaaat
     3661 ccaggaaata gaataaaaga gttagcaact acagtggatg gaatagatgc aattgtagct
     3721 ggtcatactc atgaaaaaat agatgaacac aaatataaaa ataaatctgg agatgaagta
     3781 attgttacac aaccaggttg gcatggagat agagtatcag agattaattt caaactaaat
     3841 aaagagaatg gaaagtggga cataaaggaa aagtctagta aattaaaaat aattgataaa
     3901 gaagtaagta tagttgctac tgcagattta cattcacatt tctctgataa attaacagtt
     3961 gaccttgtta atgaacgaag taacccaatt gaacctgttg tagtagatgc aggcgacttc
     4021 ttagaccctc aaacagatga aatgactcaa tggtataaag agtggaaaag tataagagat
     4081 aataatagtg ataaaacgat tagtagatgc ccaatggtca tggatatgaa tcagggaatg
     4141 tatgatgcag tagtacttgg aaatcatgaa tttgtatctg aaaaagatga attttggtca
     4201 gatgaacgcc ttttagatgc tgttatagag gattttgaac aggtggcaat ttctgtgtta
     4261 tcggcaaata tatataggca atctggtaaa aattatgtta aaccatatat tataaaagat
     4321 gtggagacga gtgaaggtaa tgtaaaagta ggaatattgg gacttactat aaaagaagta
     4381 ggtaaaggtc ttaaaaatgt aaacttacaa gagcaatttc aatataagga taaattgtat
     4441 gcaaatgatt tagtggaaga tgcaaagaaa tgggtaaaag ttatgaaaaa gaaaaaacca
     4501 gatataatag ttgcagttgt acattcagga gaagaaccaa aaaatccaaa acatccagga
     4561 aatagaataa aagaactagc aactacagta gatggtattg atgcaattgt tgctagtcat
     4621 actcatgaaa aaatagatga gcatgaatat aaaaataagt ctggagaaaa agttatagtg
     4681 acacaaccag gtgagcatgg taaatattat tctaaaatta cctttaaagt aaataaagaa
     4741 aagggttcgt ggactattaa tgataaattc agtaaaacaa ttgaggttga ataactttat
     4801 aaaatttata gataaagtaa attatctgat attggcatga tatataagat aaagtttcta
     4861 atattagtat aatgcataat gtgaaatatt ttaataataa gagaataaac aagacaaata
     4921 aaaatatttt aacatgtaag atatagtatg aactattata ctaatgctta ctttataatt
     4981 tgaacatgtt agaataagtc ttatttgaaa attttagtgt actagagtaa gtattatttt
     5041 actagtaaaa aatattgaga actatatgta gatttgctta aaaaggaatt tacatatagt
     5101 tcttttcgta taataaatag tacaatctta tatggtaaag ataaagtgtg atattaaatt
     5161 ttattatcat ccaaaatcta aggaggagtc tcttatgaaa ataaaattta ttatagtagc
     5221 atcaataata tttttaatag tattacttgt ggggtgtcaa agtactaaag acacagaaat
     5281 caatgtactc gccacaagtg atttacattc aattattcca gataatttaa tttcctatgt
     5341 agaagaggag agaaaatatg atgagaatct acttatggta gatgcaggag atttttttga
     5401 catgcaaagt ggtgagatga ataagtggtt tactggtcaa aaattagtaa gatttaaaga
     5461 tgggatacca gagtacaaaa aaatagctga accacgtgaa ggagaagttc cattggctaa
     5521 aaaaatggca aagctgaagt atgatgcagt tacatttggg aatcatgaat ttgtatctaa
     5581 tgacaagcag agccttgata aattggtttc tgattttaaa aataacaata taccattagt
     5641 atcagcaaac gtatatgaac aatctggaga aaactacgta aagccatatg taatgaaaaa
     5701 tataaatact gacaagggaa ctgtaaaggt tggtatactt ggtctgacta taaaagaagt
     5761 aggggaacgt tcaaggttta aaagttttga acaagataaa aaggctagag aacttgggga
     5821 acaacctcaa tacaaaggga aattatatgc aaatgattta gtagaagatg caaataagtg
     5881 ggtaaatgtt atggaaaaaa aagaaaagcc agatataata gttgccattg tacattcagg
     5941 tgaagagcca aaaaatccta aaaatccagg aaatagaata aaagaactag caacaactgt
     6001 agagggaata gatgctattg tagcaggtca tacacatgaa aaaatagaac agcatacata
     6061 taaaaataat tctggtgaag aagtaatagt aacacagcct ggagctcatg gtaatagtat
     6121 atcaaagatt aattttaagt tggataagaa gaatgataag tggtttataa aagacaaata
     6181 tagtgaatta aaggtttttg gaaaggaagt aaatataatt acaacttctg gtctgaatcc
     6241 aaaattttca gatgaaatgg cagttaattt gtttaatgaa agagatagag atgttcaacc
     6301 tatctttata gatactggag attttttaaa tactaataca aaagaaatga ctaagtgggc
     6361 taaagagtgg caatacaatg aaaataaagg catctataaa aaaataaatg aatggccaat
     6421 tgtatatctt ggttatgatg ctgtagtact tggtagccat gaatttacag aggataaaga
     6481 gacttttgag gaaaaaaaat ctacattgga ttatattata gaaaactttg aagaaatgaa
     6541 gataccagta ttatcagcta atatatatga tgaatctgga gaaaattatg taaaacctta
     6601 tataattcat aatgtagaaa ctagggaagg aaatataaag gttggagtat taggtcttac
     6661 tactactgat aaggatgaag aagacttaag taactcaagc ttaagcaaag actcaaagac
     6721 ttcgaaaatt cctgaagaaa caggaaagtt atatactaat aatctagtaa aagatgcaag
     6781 cgaatgggta aaagttatgc aaaaggaaag tcctgatgtg attgttgcag ttgtacattc
     6841 agataataat agtactctaa aaaatccaag tagtgaagtc aaaaaacttg caatgtcagt
     6901 agatggaata gatgctattg ttgtaggtca tacgaaaaat aaggtagaag aacatattta
     6961 caaaaataag tctggggatg aggttatagt aacacaatct ggagaagatt gttattcaaa
     7021 aataagtctt gaactaagaa aagaaaatgg caagtggaat atcataaaca aatatagtaa
     7081 agcaataaaa atgaagtgaa tttattgata tataaaccat tattaacact gatttttata
     7141 atataa
//
LOCUS       DAEQCW010000144         7047 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.145, whole genome shotgun sequence.
ACCESSION   DAEQCW010000144 DAEQCW010000000
VERSION     DAEQCW010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7047)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7047)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7047
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.145"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            48..428
                     /locus_tag="KRO40_003270"
     CDS             48..428
                     /locus_tag="KRO40_003270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2094067.1"
                     /translation="MINKIGKITLYVNNQEDAKLFWTEKLNFVVTYEKEMGPNMKWVE
                     VAPSKNEFTTFVLYDKNLMMKQNKEINVSHPSIILSTRDINGTYEQMANNEVEVGELM
                     EMPYGRMFSFKDQDGNDYLVREDK"
     gene            553..753
                     /locus_tag="KRO40_003271"
     CDS             553..753
                     /locus_tag="KRO40_003271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094068.1"
                     /translation="MFKKMAVLKDIATKIGRKKAYELLEMVEGNDAFVAEVKIKKNGI
                     ESKKEEIMLKDNQKIILEYIEG"
     gene            949..1677
                     /locus_tag="KRO40_003272"
     CDS             949..1677
                     /locus_tag="KRO40_003272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2094069.1"
                     /translation="MLEIKNLSFNVESNNEELGIINDVSLSFERGKLIVITGPNGGGK
                     STIAKLIMGIEKATSGQIILDGEDITNLSITERAKKGIGYAFQQPPRIKGMTVENLLT
                     LAHGKPLSTDVCCQYLTDVGLCSKDYLNREVDNSLSGGEMKRIEIATLFARDLKVSIF
                     DEPEAGIDLWSFGKLNESFKKIHEESNQTIIIISHQERILELADEIIVLQDGSVKSHG
                     TKEAILPEIMCQVNSSCELMKDMN"
     gene            1699..2616
                     /locus_tag="KRO40_003273"
     CDS             1699..2616
                     /locus_tag="KRO40_003273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufD family Fe-S cluster assembly protein"
                     /protein_id="HBH2094070.1"
                     /translation="MNKIDLNLLEKVAELRGTPLGAYNIRKNGQGVERHSTENVTIIP
                     KTDKPGIDIIVKPNTKGENVHIPVIVTEAGVQDMVYNDFEIGENADVVIIAGCGIHNC
                     GCDDSEHNGIHRFFLRKGARLKYVEKHYGEGDGEGKRILNPVTIVNMDEDSYCEMETI
                     QIKGVDSTKREMDANLGKGAKIVVFEKLLTHGNQVAESNMKVILEGENSSAQVVSRTV
                     GQDNSKQKFNPCVIGDSLCSAHVQCDSIIMGNSQISAIPEIAANHPDALLVHEAAIGK
                     IAGDQILKMMTLGLTEEEAEQQILNCFLK"
     gene            2758..3942
                     /locus_tag="KRO40_003274"
     CDS             2758..3942
                     /locus_tag="KRO40_003274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH2094071.1"
                     /translation="MKNLLIRNGTIISPTDGIKFEKRDILVLHGKIYAIGLNLKEKIR
                     KEKLLTNKEFEIINADNMYISPGFIDVHTHCYKRKLPTGMDSDSIGIEKGSTVIFDAG
                     TAGPSNYYDFKKKYMDECKTEVYSFLNVTNEGLNILNESTSLDVINFDKVESIVEKNI
                     EKIKGIKVKASKFQSNESGIDIIKKSKQVAKKINLPLVVYIGEYPSYIDEVMNILGKG
                     DVVTPVYGNSTNGILKESGTLRKSVINAKNRGVLFDVCHGVDQFDFKVFKKAIKQGLE
                     PDLISTDMHIKNMKDVNYSLLNVINKIMELGISLEKCIEKVTEYPTKIFDLHGNKGRI
                     KIGGEGDFTIFTMEECNDIIKDYNNNELVLNKKLRLQYTVKSWMKSSEVYRHGYENTI
                     IN"
     gene            4049..4237
                     /locus_tag="KRO40_003275"
     CDS             4049..4237
                     /locus_tag="KRO40_003275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBH2094072.1"
                     /translation="MKAFVDKDVCVACGACIGTCPDVFSMSDEGHSVAIEGEIPEDLQ
                     DLCKEAEEGCPVSAITVK"
     gene            4386..5036
                     /locus_tag="KRO40_003276"
     CDS             4386..5036
                     /locus_tag="KRO40_003276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBH2094073.1"
                     /translation="MKKNYEIVLFDLDGTLTDPKEGITKSIQYSLNSFGIKEDLENLD
                     QFIGPPLHDTFKEYYKFEDKKAKEAVEKYREYFADKGIFENKIYENMKEILEMLYKNG
                     KILLVATSKPTVFAETILRYFDIDRYFKYIAGSNLDGTRVNKNEVIQYVLDLCNVKDK
                     DKVIMVGDRKYDIIGAKKIGIDSIGVLYGYGSFEEISESEPTYIVENVESIKDILL"
     gene            5139..6077
                     /locus_tag="KRO40_003277"
     CDS             5139..6077
                     /locus_tag="KRO40_003277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBH2094074.1"
                     /translation="MKSILIMGGSDFIGSALAKRLIKCGYQIDILTNGKKEIDYNGFK
                     EHLICDRKVRKDMENIITGRKYDYIYDMTAYTKEDVSNLIDFISMDNLKKYIVLSAGA
                     VYKDSGRNIKEENEKGENENWGKYGLNKKEAEDFIINSPIPYIIIRPTYIYGENNNLY
                     REYYFFEKIEKNEKIPVPKGKQVSNQFIYIGDLVKVLESIMKNPHVREAYNVTNPQLI
                     SWDDLIYTCGEIIGKEPIIKYVDMEKVEFRERTYFPFRNIDFNLDINKLIEHGLYIPN
                     VLLKEGLTATYKWFSANKPKMHDRKMNKVESVMQIV"
     gene            6199..6954
                     /locus_tag="KRO40_003278"
     CDS             6199..6954
                     /locus_tag="KRO40_003278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBH2094075.1"
                     /translation="MKKYNISENGALIKNDTIESKSESVKVVQISDTQIGSFYSTKNL
                     KKVANKINTLNPDIIVFTGDLIDYSNKNPSVDEITTILSSMNARLGKFSVFGNHDYMY
                     KLPRYYRHIMKNSNFNLLVNENKKIKLKDDKYINILGVDEILNGNPNIKYLESQIDNK
                     SFNLLLAHEPDLVDMLSKDTMNLVLSGHSHGGQIRLPIKGALVTPPYGRKYTKGFYDI
                     NGNHLYVSSGLGSTKLPFRFFNIPEIIEFNIII"
BASE COUNT         2910 a          665 c         1269 g         2203 t
ORIGIN      
        1 tataaaaaat attaggtatt tatttaataa taaaggtggg tattgttatg ataaataaaa
       61 taggaaaaat aactctctat gtaaataatc aagaggatgc aaagttattt tggacagaaa
      121 aattgaactt tgtagtaact tatgaaaagg aaatgggtcc aaatatgaaa tgggtggaag
      181 tagcaccaag taaaaatgaa tttacaacat ttgtgttgta tgataaaaat ctaatgatga
      241 agcaaaacaa agagataaat gtatctcatc catcaataat tttaagtaca agagatatta
      301 atggaactta tgaacaaatg gcaaataacg aggttgaggt tggggaatta atggagatgc
      361 catatggaag gatgttttct tttaaagacc aagatggaaa tgattatttg gtcagagagg
      421 ataaataatt ttacaaagta ttaaatttac tcaatatctg atataattag agacaataat
      481 tattataaac tagtctagga ttagaattat ataattaaaa attaagtgta aattttgagt
      541 agaggtgata aaatgtttaa gaaaatggca gtactaaaag atatagcaac taaaataggt
      601 cgtaaaaaag cgtatgaact attagaaatg gttgaaggta atgatgcctt tgtagctgag
      661 gtaaagataa aaaagaatgg aatagaatct aaaaaagaag aaattatgtt gaaagataat
      721 caaaaaataa tattagagta tatagaaggt taaattttaa atacatataa gttgatatac
      781 taaatttctg agatgagttt acataaaact catctttttt acttttcaat aactttgttt
      841 tattatttaa tatacatttt atctccttag agttgctgat atataaaaat tactgatata
      901 ataaaagaat ggatattaat gtaatatttt atagaaaaga ggggtattat gcttgaaata
      961 aaaaatcttt cctttaatgt tgagtctaac aatgaggaac taggaataat aaatgatgtt
     1021 agcctttcat ttgagagggg aaaacttatt gttatcacag gtccaaatgg tggaggaaaa
     1081 tctacaattg ctaagcttat tatgggaatt gaaaaagcta cgagtggtca gataatttta
     1141 gatggagaag atataacaaa tcttagtatt acagaaagag caaaaaaagg aataggatac
     1201 gcatttcaac aaccaccaag aataaaaggt atgacagttg aaaatttact tacacttgct
     1261 catggaaaac cattgtctac tgatgtatgt tgccaatacc ttacagatgt tggattgtgt
     1321 tcaaaagact atttaaatcg tgaagttgat aactctcttt ctggagggga aatgaaaaga
     1381 attgagatag caactctttt tgctagagat ttaaaggttt ctatatttga tgaacctgaa
     1441 gcagggatag acctttggag ctttggaaaa ctcaatgaaa gttttaagaa aatacatgaa
     1501 gagtctaatc agactataat cataatttct caccaagaaa gaatattaga gttagctgat
     1561 gaaataattg ttctacaaga tggttcagta aaaagccatg gaacaaaaga ggctatatta
     1621 cctgaaatca tgtgtcaagt taattcaagt tgtgaattaa tgaaagacat gaattaatta
     1681 gaaaggaagg caaattaaat gaacaaaata gatttaaatc ttttagaaaa agttgctgaa
     1741 cttcgtggaa ctccattagg agcatacaat atacgtaaaa atgggcaagg agtagagaga
     1801 cattcaactg aaaatgtaac tataattcct aaaactgata aacctggaat agatattata
     1861 gtaaagccaa atacaaaagg agaaaatgta catataccag taatagtaac agaggctggt
     1921 gtacaggata tggtatataa tgattttgaa attggagaaa atgcagatgt tgttataatt
     1981 gctgggtgtg gtatacataa ctgtggttgt gatgatagtg aacataatgg tatacataga
     2041 tttttcttac gtaaaggagc tcgcctaaaa tatgtagaaa aacattatgg tgaaggtgat
     2101 ggagaaggaa agagaatttt aaatccagtt actattgtca atatggatga ggattcatat
     2161 tgtgaaatgg aaacaattca aattaagggt gtagattcaa ctaaaagaga aatggatgca
     2221 aacctaggta aaggagctaa aatagttgta tttgagaaat tattaactca tggtaatcaa
     2281 gttgcagaat ctaatatgaa ggttatctta gagggtgaaa actcttctgc tcaagtagtt
     2341 tctcgtacag ttgggcaaga taattctaag caaaagttta atccttgtgt tattggggat
     2401 tccctttgtt ctgcacatgt tcaatgtgat tcaataatta tgggaaattc tcaaattagt
     2461 gctatacctg aaattgctgc aaatcatcca gatgctcttt tagtacatga agcagctatt
     2521 ggaaagattg caggagacca aatactaaag atgatgacat taggtcttac tgaagaagaa
     2581 gccgagcaac aaatacttaa ttgcttctta aagtaaatta aagattttat ttaatttaat
     2641 ataattaata tagtataata tagtgaataa gtctaaaata tttttatttt taggcttatt
     2701 ttctttatgt aagaaaagct attagagaaa ttatattgta attaggatgt ggaataaatg
     2761 aaaaatttac ttataagaaa tgggacaata atatctccaa cagatggtat caaatttgaa
     2821 aaaagagata tcttggtttt acatgggaaa atatatgcta ttggattgaa ccttaaagag
     2881 aaaataagaa aagaaaaatt acttacaaat aaagagttcg agataataaa tgccgataat
     2941 atgtatattt ccccaggatt tatagatgtt cacacccatt gttataagag aaaattacct
     3001 acaggtatgg attctgattc aattggaatt gaaaaaggtt ctacagttat atttgatgca
     3061 ggtacagctg gtccttcaaa ctactatgat tttaaaaaaa agtatatgga tgagtgtaaa
     3121 acagaagtat attctttttt aaatgttaca aatgagggac taaatatatt gaatgaatca
     3181 acttctttag atgttataaa ttttgacaag gttgagtcaa ttgtagaaaa aaatatagaa
     3241 aagataaagg gtataaaagt aaaagcgagt aaatttcaat ctaatgaaag tggtatagat
     3301 ataattaaga aatcaaagca agttgctaaa aaaataaatt tacccttagt ggtatatata
     3361 ggagagtatc catcatatat agatgaagta atgaatattt tgggaaaagg agatgtggtt
     3421 acaccagtat atggaaatag tacaaatgga atccttaaag aatctggcac attaagaaaa
     3481 tcagtaataa atgcaaagaa tagaggagta ttgtttgatg tatgtcatgg agtggaccaa
     3541 tttgatttta aagtttttaa aaaagcaata aagcaaggtt tagagcctga cctaataagt
     3601 actgatatgc atataaaaaa catgaaagac gtaaactatt ctcttttaaa tgttataaat
     3661 aaaattatgg aacttgggat atccctagaa aagtgtatag aaaaagtaac tgaataccca
     3721 acaaagattt tcgatttaca tggaaataaa ggcagaataa agattggtgg agaaggtgat
     3781 tttacaatat ttacaatgga ggagtgtaat gatattataa aagactacaa taataatgaa
     3841 cttgttttaa ataaaaaatt aagattgcaa tatactgtaa aatcatggat gaaaagcagt
     3901 gaagtttata gacatggata cgaaaatact ataataaact aaacaatagt gataaaataa
     3961 taaatatatg tttaaattgg tatatattgg ataaatatct aaggaaacaa caattaaaaa
     4021 ataataattt taggggaggt attttagtat gaaagcattt gttgataagg atgtatgtgt
     4081 agcttgtgga gcatgtatag gaacatgtcc agacgttttt agtatgagcg atgaagggca
     4141 ttcagtagca attgaaggag aaataccaga agatttacaa gatttatgta aagaagccga
     4201 agaaggatgt ccagtttcag ctataacagt taaatagagc tgtttaaatt tatttttaaa
     4261 ataaatatat aagatttaat tggtacttaa gctatagtat tagaaatttc tattactata
     4321 gctttttaaa atagataaac ttaatatata agatattact ttttacaaat atggaggact
     4381 gaaatatgaa aaaaaattat gaaatagtat tattcgattt agatggaaca cttacagacc
     4441 ctaaagaagg aataacaaag tctattcagt attctttaaa tagctttggc ataaaagaag
     4501 atttggaaaa cttagaccaa tttataggac caccattaca tgatactttc aaggagtatt
     4561 ataaatttga agataaaaaa gctaaagaag ctgttgaaaa gtatagagaa tattttgctg
     4621 ataaagggat atttgaaaat aaaatttatg agaatatgaa agagatatta gaaatgctct
     4681 ataaaaatgg taaaatatta ttagtagcaa cttctaagcc aacagttttt gcagaaacta
     4741 tacttagata ttttgatata gatagatatt ttaaatatat agcaggtagc aatcttgatg
     4801 gtacaagagt gaataaaaat gaagttatac aatatgtact agacctatgt aatgtaaaag
     4861 ataaagataa agttattatg gttggagata gaaagtatga cataattgga gctaaaaaaa
     4921 taggtataga ttctattgga gtattgtatg ggtatggttc ttttgaagag attagtgaaa
     4981 gtgaacctac ttatattgtc gaaaatgtag agtctataaa agatattttg ttataaatat
     5041 cttttataga caaaaatatt acaaaatggt gtcgcatatt taaaaatatg atattatagt
     5101 taaggaagtc atttaaaaaa gaggaggatg cacttaaaat gaaatctatt ttaattatgg
     5161 gtggaagcga cttcataggt tctgcacttg ctaagcgctt gattaaatgt gggtatcaaa
     5221 ttgatatact tacaaatggt aaaaaggaaa tagattataa tggttttaaa gaacatctaa
     5281 tttgtgatag aaaagttcga aaagatatgg aaaacattat cacaggaaga aaatatgatt
     5341 acatatatga tatgacagca tatacaaaag aagatgtaag taatctgatt gattttataa
     5401 gcatggataa cttaaaaaag tatatagtat tgtcagcagg agcagtatat aaagatagtg
     5461 gaagaaatat aaaagaagaa aatgagaaag gtgaaaatga aaactgggga aaatatgggt
     5521 taaataaaaa agaggctgaa gattttatta taaatagccc tataccatat ataattatta
     5581 gaccaactta catatatggt gaaaataata atttatatag agagtattat ttctttgaaa
     5641 aaatagaaaa aaatgaaaag ataccagtac caaaaggaaa acaagttagt aatcaattta
     5701 tatatattgg ggatttggta aaggtattgg aaagcataat gaaaaatcct catgtaagag
     5761 aggcctataa tgtgacaaat ccacagttaa tttcttggga tgaccttata tatacatgtg
     5821 gagaaattat tggcaaagaa cctataataa aatatgtaga tatggaaaaa gtagagttta
     5881 gagaaagaac gtatttccca tttagaaata tagactttaa tcttgatata aataagctta
     5941 ttgaacatgg gctttatata ccaaacgtgt tactaaaaga aggtcttaca gcaacatata
     6001 aatggttttc agcaaataag ccaaaaatgc atgacagaaa aatgaacaaa gttgagtctg
     6061 taatgcaaat agtttaaaaa aataaataag taggtagata ttttgaactc aaaaattaag
     6121 tattttttaa aattttttat cttaatattt attttgattt ttatatactc agttgcgata
     6181 gagccgagtc tattaattgt gaaaaaatat aatataagtg aaaatggagc attgataaaa
     6241 aatgatacaa ttgagagtaa atctgaaagt gtaaaagtag ttcaaatttc agatactcaa
     6301 ataggtagtt tttattcaac taagaatctc aaaaaagtag ctaataagat taacactttg
     6361 aatccagata taatagtatt tactggtgat ttaattgatt actccaataa aaatccaagt
     6421 gtagatgaaa ttacaactat tttatcaagt atgaatgcta ggttgggaaa attttcagta
     6481 tttggcaatc atgattatat gtataaactt cctaggtatt ataggcacat tatgaaaaat
     6541 tccaacttca atcttttagt aaatgaaaat aaaaaaataa aattaaaaga tgataaatat
     6601 attaatatat taggtgttga tgaaatatta aatggaaatc ctaatataaa atatctggag
     6661 agtcaaatag ataataaaag ttttaattta ttgttagcac atgaaccaga tttagtagat
     6721 atgcttagta aagatacaat gaatttagtt ctatctgggc atagtcatgg tggtcaaata
     6781 agattaccta ttaagggagc attagttact cctccatatg gaaggaaata tactaaaggg
     6841 ttttatgata taaatggaaa tcatttatat gtgagttcgg gtcttggaag tacaaagtta
     6901 ccatttagat tttttaatat accagagata atagaattta atattataat ctaacataaa
     6961 atatttagaa aatataattt tgctttttat aatatgtaga tgtatatact gtaaaaatgg
     7021 attaaaccag tagattgaat gaattaa
//
LOCUS       DAEQCW010000145         6986 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.146, whole genome shotgun sequence.
ACCESSION   DAEQCW010000145 DAEQCW010000000
VERSION     DAEQCW010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6986)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6986)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6986
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.146"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            240..1067
                     /locus_tag="KRO40_003279"
     CDS             240..1067
                     /locus_tag="KRO40_003279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBH2094076.1"
                     /translation="MDLSKKVKILENASDGKSEFEILEFEKLEGASSPLMAMGLYFAR
                     EAGLKARQIKIKLNNSSIKTEAGALYYYKGNISSETKIGGVGGLFKKGISGALTNESM
                     MKPVYKGTGEVYLEPSFRHYLFMSLDNDSIIVDKGLFYCCSDTIEVKAFTQKNFSSAL
                     LGGEGFFQIELSGTGVIVLECVVPQSEIVEYELKNGEELKVDGNFAIARTSGVNFSVT
                     KSDKSLIGSALNGEGFLNTFTGNGTVWLAPTQVMYEKLSFGAMPTNDNMNNKVSKQK"
     gene            2092..2556
                     /locus_tag="KRO40_003280"
     CDS             2092..2556
                     /locus_tag="KRO40_003280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2094077.1"
                     /translation="MNLNKVKFTEEHAIEVTNWKYEGKYSIYNLPPWEEIKKKNFSLA
                     KEDKRKNFISFINDNKELIGFINLLDEGSSVFFGIGMKPNYCGMGIGKEIIGLGLQEC
                     RNKYSTKPIVLNVRTWNMRAVKCYESQGFKIVETKVQKTHLGDGEFFVMRYQ"
     gene            complement(2823..3467)
                     /locus_tag="KRO40_003281"
     CDS             complement(2823..3467)
                     /locus_tag="KRO40_003281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094078.1"
                     /translation="MFGQSFQNYLVLIKENFKLSTLTNLICSIILLCMIPLIQGVANL
                     DRISTAICLENYVAIIGIVMLVPVFSLEQSKEIDEIVSSKALSQVIVQLIRILMSIIG
                     IVVLIIGFVNVLIYLGCNFPVVEYIIGSFASAMFIGSLGMFFSNLFNNTIIGYMISIG
                     YLILNMMTKGKYVGKFFIMSMSQGSFDEKYWLILGSVVLIIASLLIKPVKRKIR"
     gene            complement(3397..4686)
                     /locus_tag="KRO40_003282"
     CDS             complement(3397..4686)
                     /locus_tag="KRO40_003282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094079.1"
                     /translation="MNLFIKECKNILKSMIYYIFIVVLVFFYISQLGSSVSNDVSKNI
                     PNDGNPLVAPQKVENIEEYYSVHNQYPYGQKESMKTEKVIPNATINLIREYQKNTYTT
                     YPTGVVKYIKLDQNKTKTIEKYIEEITGKSISEINSLWKTDESIKIDYSKVSLERFEE
                     IMQRVDDILGGGSAYAFDKLQRFGVVPVTYDEAMKNYNYTIQKDKVSNGYARIFCDYI
                     GIVLSIFPVFVAVFMSLKDKRSRMREIIYSKQVSSCKIVLSRYFALVFMMILPVLILG
                     MKDLLPLIFFAKDKGISIDNLAFIKYTLWWILPTLMIVTAVGMSITILTDTPVAIIVQ
                     LIWWFYSINSTGLKGDYSTMGLMIRHNSVLNGDIIIQNFNQIMINRIVISLEALVLVL
                     LAIFLYEQKRRGNLDVWAKFSKLFSSNKRKLQIKHFN"
     gene            complement(4683..5555)
                     /locus_tag="KRO40_003283"
     CDS             complement(4683..5555)
                     /locus_tag="KRO40_003283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094080.1"
                     /translation="MEMKIAVSNLSKRFGKKQALDNINLEIDSGMFGLLGRNGAGKTT
                     FMRILATLLSKTEGSIHMCGVPIENTKEIRNMVGYLPQDFSMYPNMTVYKAMDYLAVL
                     SDIPLRKRRKIIAKLLSKVNLTNYQNVKVKSLSGGMNRRLGIAQALIHNPRVLIVDEP
                     TAGLDPEERIRFRNLLCEIANDRIVILSTHIVGDIEATCENVAILNSGKVIYNGSTEA
                     LAKLAEGKVYSIEVDKKDIENIKSRFIVIGMLTHGGKAILRIISDDKPFETAVNCNPT
                     IEDGYMLIMGGDNI"
     gene            complement(6084..6575)
                     /locus_tag="KRO40_003284"
     CDS             complement(6084..6575)
                     /locus_tag="KRO40_003284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfbM family protein"
                     /protein_id="HBH2094081.1"
                     /translation="MGMIGCYTKISEENVFKLQQAEENLQDFVFEDANENSTINIDKA
                     WHAIHFTLTGCPFGGDDDNIFSKLVLSGNILMEIDGEFPVMLITANDVKKLSKAMNSL
                     EEQAFRKRFNINEMLENNIYPVMNDESEDDFFEYVWANLIELKKFIQEASNDGLAVIF
                     FIM"
BASE COUNT         2558 a          947 c          823 g         2658 t
ORIGIN      
        1 ataattttaa catgcccata aaatataata cccacaaatg ataaataata ctcaaaatat
       61 ctattgaaat aactatacat ccttaaataa cttaacttaa atctaaacat ttcaaaaact
      121 tcttaaaaat atgtaaaaat ttgatgataa agtagcgatt ttttcaaaaa aaatgtaata
      181 tagagttata tcttataata ttttagagat aaattttatc atagtgggga gaaatttgta
      241 tggatttaag caaaaaagta aaaattttag aaaatgcatc agatggcaaa agcgaatttg
      301 agatattaga atttgaaaaa cttgagggag cttctagccc attaatggca atgggattat
      361 attttgctag agaagctggt ttgaaagcta gacaaattaa gataaaatta aataattcat
      421 caataaaaac agaagctggt gcattatact attataaagg aaatatatct tctgaaacta
      481 agattggtgg tgttggaggt ctttttaaaa aaggaatatc aggagcactt actaatgaat
      541 caatgatgaa acctgtatac aaaggtactg gagaagttta tttggaacct tcttttagac
      601 attatttatt tatgagtctt gataatgatt ctataattgt tgataaagga ttattctatt
      661 gttgctctga tacaatagaa gtaaaagcat ttacacaaaa gaacttctca tctgctttac
      721 ttggtggtga aggcttcttc caaatagaat taagtggtac tggtgtaatc gttctggaat
      781 gtgttgtacc tcaaagtgaa attgtagagt atgaattgaa aaatggtgaa gaattaaagg
      841 tagatggtaa ctttgcaata gcaagaacat ctggtgttaa tttttctgtt acaaaatcag
      901 ataaatcttt aattggttct gctttaaatg gtgaaggttt cttaaataca tttactggta
      961 atggtacagt ttggctagct ccaactcaag taatgtatga aaaactaagt tttggagcaa
     1021 tgcctactaa tgataatatg aataataaag tttctaagca aaaatagttg ttttataaat
     1081 atttattaaa tcattattga ttttataaag tcactataaa ttttattaga ttattattat
     1141 aaaatcagag tgtggaaatg tttatgtgta ttctttaaat aaaaatttcc acattctgta
     1201 aggttattat acttgatata taaaattcaa tttaggaaca tagtctaaca tttataaaca
     1261 tattaaggta atgatttctc ttagtaatta ttctcatatc ttattctttg attatattta
     1321 tcttattcct agcccttatg tcatattata tttcttatct tattatttat aattagcatt
     1381 aacttatcta aaatcttgta tttttttaat agtaaagttt acatctatat taaaaagttt
     1441 acatctatat taatttcata aaacaatcaa ggtagtcaag agattcaact ttatttgatt
     1501 ttaaaaattt aagtgaattt gttcttatac acaccttttt aaaattatat ctgtagaaaa
     1561 tatcatttag agctataatt aaattaactt attaaatttt agaaaattta ttaaaaaata
     1621 taagttaaat taatgttttt aaagattctt ttttgtaact actagaatac taatttagta
     1681 gttattgtat ctctaaagtt taagcatgga tagatataca tttgataatt tgcctataat
     1741 ttacctacta cttggattat tggagcaaat acaatatatt aataataagt tcctaaaacc
     1801 aataaattaa ctaatacaca taaagatatt gatgttggtt atacaactat aagaaacgga
     1861 tttaacagaa tttaatcaag ctaagaaatt atatatatat cgtgatattt ttgaattaga
     1921 aggtaattca aaattagttt atagtcttct gtgaatccaa taaaaagtac agggtacaag
     1981 aattgttagt aaaattttta aagattttat ggataaatat aaatagtttt actcattgtc
     2041 taaaacttta aaataccatt aattacctta aatattttaa taggaggaca tatgaattta
     2101 aataaagtta aatttactga agaacatgct attgaagtta ctaattggaa atatgaaggt
     2161 aaatattcaa tatacaatct acctccatgg gaggaaatta aaaagaagaa tttttcacta
     2221 gcaaaagaag ataaaagaaa aaattttata agttttataa atgacaataa agaattgata
     2281 ggttttataa acttattaga tgaaggaagc tctgtattct ttggtattgg tatgaaaccg
     2341 aattattgtg gaatgggaat tggtaaagaa ataattggcc taggattaca agaatgtaga
     2401 aataaatata gtactaaacc aattgtatta aatgtaagaa cctggaacat gagagctgta
     2461 aaatgttatg agtctcaagg atttaaaata gttgagacta aggtacagaa aacgcattta
     2521 ggagatggag aattttttgt tatgaggtat caatagttta taacaatagt cttattgtta
     2581 atacaacaat taaaatgaaa aaatacatat gtgtaggcca tagcaataag tgtctttgaa
     2641 atataaattt gagagctttt gataaaattt ggtatacata tatattttat actacggata
     2701 tataaatcta tctacatata taaagagatt gtaagtaggt ttgtgtatat aaaaatagat
     2761 ttatatttca taaatgtact ttttatttgt attaccttta ttttatctaa gctctcattt
     2821 tattatctaa tcttcctttt tactggtttt attaatagag atgcaattat caacacaaca
     2881 cttccaagta tcagccaata tttctcatca aaactacctt gactcataga cattataaaa
     2941 aattttccaa catacttgcc tttagtcatc atatttaaaa ttaaatatcc tatagatatc
     3001 atataaccta tgattgtatt attaaataaa tttgagaaaa acattcctaa acttcctata
     3061 aacatagctg atgcgaaact tccaataata tactcaacta ctggaaaatt acatccaaga
     3121 tatattaaaa catttacaaa acctatgatt aataccacta tacctataat tgacatcagt
     3181 atcctaatta attgtacaat aacttgagat aatgcttttg aagatactat ctcatcaatt
     3241 tcttttgatt gctctagcga aaatacaggt accaacatta ctatccctat tattgcaaca
     3301 taattttcta aacatatagc tgttgaaatt ctgtctaaat tagctactcc ttgtattaga
     3361 ggaatcatac atagcaatat aattgaacat attaaattag ttaaagtgct taatttgaag
     3421 ttttctttta ttagaactaa atagttttga aaactttgcc caaacatcaa gattccccct
     3481 tcttttttgc tcatataaga atatagctaa caaaacaagc accaatgctt ccaagcttat
     3541 cacaattcta ttaatcataa tttgattgaa gttttgtata ataatatctc catttaatac
     3601 actattatgt cttatcatta gtcccattgt tgaataatca cctttgagtc ctgtagaatt
     3661 tatactgtaa aaccaccaaa ttaattgcac aataattgct actggtgtat ctgttaatat
     3721 agtaatactc attcctacag ctgtaactat cataagagtt ggtagtatcc accataatgt
     3781 atattttata aatgctaagt tatcaataga tataccttta tctttagcaa agaaaatcaa
     3841 aggaagtaaa tctttcatac ctaaaattaa tacaggcaat atcatcataa agacaagtgc
     3901 aaaatatctt gataaaacta ttttgcatga agatacttgt tttgaataaa taatctctct
     3961 cattcttgaa cgcttatctt taagtgacat aaaaactgcc acaaatactg gaaatatact
     4021 taaaactata cctatataat cgcaaaaaat tcttgcatac ccattactaa ctttatcttt
     4081 ttgtattgta tagttgtaat tcttcatagc ttcatcatag gtaactggaa ctactccaaa
     4141 tctttgtaac ttgtcaaaag catatgcaga ccctcctcct aaaatgtcgt ctactctttg
     4201 cattatttct tcaaatcttt caagagatac tttagaataa tctattttta tactttcatc
     4261 agttttccaa agtgaattta tttcgctaat acttttacca gttatttctt ctatatattt
     4321 ttctatggtc ttcgttttat tttggtctaa ttttatatac ttaactaccc ctgttggata
     4381 cgttgtatat gtgttttttt gatattctct aattaggttt atagttgcat ttggaatgac
     4441 tttttctgtt ttcatagatt ctttttgacc atatggatat tgattgtgta cagagtaata
     4501 ttcctcaata ttctctactt tttgtggagc aactaatgga tttccatcat taggaatatt
     4561 tttacttaca tcatttgaaa ctgaacttcc aagttgagaa atatagaaaa aaactaaaac
     4621 tacaataaaa atataatata tcatactctt taatatattt ttacattctt ttataaatag
     4681 attcatatat tatctcctcc cattataagc atatagccat cttcaatagt tggattacaa
     4741 tttactgctg tctcaaaagg tttatcatct gatataatcc taagtatagc ctttccacca
     4801 tgagtcaaca ttcctataac tataaatcta ctttttatat tttcaatatc ttttttatct
     4861 acttcaatac tatatacttt cccttcagct agttttgcta atgcttctgt tgagccattg
     4921 tatatgactt ttccactatt caatatagct acgttttcac atgtagcttc tatatctcca
     4981 acaatatgtg tagataaaat aacgattcta tcatttgcaa tttcgcatag taaatttcta
     5041 aatcttatac gttcttctgg gtcaagacct gctgtcggct catctactat taaaactcta
     5101 ggattatgaa ttaatgcttg tgctatccca agccttctat tcatacctcc agataaagat
     5161 tttactttca cattttgata attagtaagg tttactttgc ttaataactt tgctataatt
     5221 tttcttcttt ttcttagtgg tatatccgat aaaactgcta aataatccat tgctttatat
     5281 actgtcatgt taggatacat tgaaaaatct tgtggcaaat aaccaaccat atttctaatt
     5341 tccttagtat tctcaatagg aactccacac atatgtattg aaccttctgt ttttgataat
     5401 aaagtggcta aaattctcat aaatgtggtt tttcctgctc catttcttcc taaaagacca
     5461 aacataccac tgtcgatttc aagatttata ttatcaagtg cttgtttttt cccaaatctt
     5521 ttgctaagat tggatactgc tattttcatt tccatatata aatacacccc cagaaacaat
     5581 tttatagaat tttattttta taaattttta ctgtattttc ataataaatt ctaaaactta
     5641 agatattatt tataaatttc taaatttttt ctaaagattt taatttttct gtttttaatt
     5701 aaattaaagt atctttgttt ctgaaatttt ttaagtttat gaagttataa tttaatatat
     5761 atttatttta tttgtgagtc tatttttata tataatgaaa aatgtgataa gtatccaaaa
     5821 gaattactgg atataataag atagggtatt tagcctttta agataaataa aaatatctgc
     5881 aactatatat tgcaaaaatt taaaactaat ttatatatgc taatataaat atttataaag
     5941 acataagaca aatttaccta cagatttaaa tttaacttat atattttaaa aggctaatat
     6001 aatatgtatt ttcttctata caatcaaaag gcttcatatc taagatatgt gatgacacta
     6061 atattcacaa tttttagtaa ttatcacatt ataaaaaata ttacagctag tccatcatta
     6121 gatgcttctt gtataaactt tttaagctca attagatttg cccatacata ttcaaaaaaa
     6181 tcatcttcac tctcatcatt cataacagga taaatattat tttctaacat ctcattaata
     6241 ttaaatcttt ttctaaatgc ttgttcttcc aaactgttca ttgcttttga tagttttttt
     6301 acatcatttg ctgtaatcaa catgacagga aattctccat caatttccat aagtatgttt
     6361 ccacttagta ctaatttgct aaatatatta tcatcatctc caccaaaagg acaacctgtc
     6421 aaagtaaagt gaatggcatg ccatgcttta tcaatattga tagtactatt ttcgttggca
     6481 tcttcaaaaa caaaatcttg taaattttct tctgcttgct gtaatttaaa aacattctct
     6541 tcacttattt tagtataaca tcctatcatc cccataatta cattcctcct aagtagcgtt
     6601 tttttaattg taacttataa ttaaacttag ttacaataaa atatattgag aaaagtatta
     6661 tttcatctta aatttaaata cctatattat caactaaaat tctgtgttta tagcgtaagt
     6721 attattattt tttcctaaaa atcaaatgaa tcagaagttc tataggcaat attgactata
     6781 aataagaact attactttta aaaaaaattt aagaaattat actgtagaat catgctctac
     6841 ttattagctt caaataaaaa ataaatcatg ttctcaaatt aaataataaa taacaataaa
     6901 tttaaatttt aaactataag agtttctgaa gtgttaataa gcataccaat aattatatgt
     6961 gtaagaattt gatttaatag atatga
//
LOCUS       DAEQCW010000146         6958 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.147, whole genome shotgun sequence.
ACCESSION   DAEQCW010000146 DAEQCW010000000
VERSION     DAEQCW010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6958)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6958)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6958
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.147"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            97..669
                     /locus_tag="KRO40_003285"
     CDS             97..669
                     /locus_tag="KRO40_003285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class B sortase"
                     /protein_id="HBH2094082.1"
                     /translation="MKKLVKILINIICIITLIFSSLSIYIKLSEYKKADEVYTELREN
                     TINNSKYQELYDKNNDYRFWLKINNVNIDYPVVQGYNNDFYLTHDFYKNYLPLGSIFM
                     DYRNNFENDKSLIVYGHYMKNKTMFGQLENYTDEVFFKENNLVEINYKVQTYTYEIFS
                     VYTADLINRDYLSIHFNNNDEFKYSLNYIT"
     gene            complement(1682..2344)
                     /locus_tag="KRO40_003286"
     CDS             complement(1682..2344)
                     /locus_tag="KRO40_003286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094083.1"
                     /translation="MKMLKVIDIKKIYGKGENEIKAVDGITLEIEPHKFSAIIGQSGS
                     GKSTLLHCMAGLDKPTLGNVFMDNLDLYTLSDEKLSNLRSKEFGFIFQNYNLIPVINV
                     YDNIVLPILIAKGKIDNNYINDLITKLGLESQINKFPNELSGGQQQRVAIARSLANKP
                     SIIFADEPTGNLDSKTTNEVMNLLKYCVNEYKQTLVMITHNDEIAKMADCIITISDGK
                     VI"
     gene            complement(2361..4916)
                     /locus_tag="KRO40_003287"
     CDS             complement(2361..4916)
                     /locus_tag="KRO40_003287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBH2094084.1"
                     /translation="MGIYLKMSLAYLKKNKLRTLLLIIGVMLGVMLIFGPSVIKDSQN
                     ENNVVAIHELYSGYHVEFSDLTLDDAKKLETDEKVSKGNSVQNLGRISDKKGNSFILT
                     SSNEEYLKSRYNKIIEGRLPKNNNEIVLEKKALEAMNLSEGVGSTLNLTIKKNYKDTN
                     GSNRLFSINKEFKIVGVMEKPKGYYDVVWQYEAVTYGNDETNNIIPHDAISYNSILSF
                     KSGWRNIEGECDYLMKKYKLGQKSFLPNVPLVRELRYVEDDKNDPNVFKRNVLITTVS
                     IIFIFNIFNITLNQSVKEMGLFRLMGAKKRNVRCMIIYQALIITIIGILLGLVAGVTY
                     SYIGISNYNEVLYSEAGLNPKLYINNEIVIKAILVGIISVFISCIIPTFKIGKISPIE
                     SIINTDKIKNHRSRLGIDRLVSKIFGFYGFMGLKNIGRNKVRAAISMLSIALGGYIFI
                     TTFSSMQEEVNSKIEDMQNRYNITMQFGVNADPQISKYTDSDVENIEKIKGVKSIHKI
                     QITNGMFTFNNKDINKEFTTYNGVEKKEIMEDKLVLKLYDDDYIDEKLNDFVEEGSLD
                     DIKKDTDGYPNVAVYNYFYDIVDDHTIKPIFKELNIGDIITVKIPVEENNTIVYKEMK
                     VRVAVILKDEWIAMGDGDFMPDLEIITSNIHSKNITGEQKYTQLGINLENPYDEIVNN
                     EIQKISRSIPGSLFNSRLSYHEMSESIYKSYIKSQIAIIALVLIIASINIFCTIRTNL
                     LIRKKEISTLRALGVSLKNMKKMLIYEALAYAVFSFIIAMIPSFINLVKFTNWNNDAY
                     INYGIENFMSFTFPIKESLLFFAISVFVCLIAVVVSNRDFESMNIIEGIKENE"
     gene            complement(5149..5343)
                     /locus_tag="KRO40_003288"
     CDS             complement(5149..5343)
                     /locus_tag="KRO40_003288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="HBH2094085.1"
                     /translation="MRKYKAILLTLIISIIAIIGFIIYNNYFRKWNEAEKYIDKYMTY
                     QGVSGDDIERITKEKYTKEN"
     gene            complement(5355..5534)
                     /locus_tag="KRO40_003289"
     CDS             complement(5355..5534)
                     /locus_tag="KRO40_003289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094086.1"
                     /translation="MIHVEISEKEFFRKIEEVFDKGEGNIEVDNLGDIKIQVKKFDDK
                     TKSLELKLIKEFKLK"
     gene            complement(5539..5796)
                     /locus_tag="KRO40_003290"
     CDS             complement(5539..5796)
                     /locus_tag="KRO40_003290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094087.1"
                     /translation="MSKKISESIENSGLRVAENKSDGSFVLSLGNLEYTKEQPSQVLH
                     YSMTKDKKGTKEILSIQCVKDFSYNEKLSEDDKFIMAIYNI"
     gene            complement(6056..6958)
                     /locus_tag="KRO40_003291"
                     /pseudo
     CDS             complement(6056..6958)
                     /locus_tag="KRO40_003291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428529.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="sensor histidine kinase"
BASE COUNT         2364 a         1052 c          701 g         2841 t
ORIGIN      
        1 ttataagtat tcattatttg ctaaataact acaataaaaa ttttaattat ataaaattta
       61 tttaatcttt tatataataa tacaaggggt aattaattga aaaaactagt aaaaatatta
      121 ataaatatta tttgcattat tacgctaatt ttctctagcc tttcgattta cataaaatta
      181 tctgaatata aaaaagctga tgaagtatat acggaactca gagaaaacac tatcaataat
      241 agcaaatatc aagaacttta tgataaaaat aatgattata gattctggct taaaataaac
      301 aacgtaaata tagactatcc tgtagtacaa ggatataaca atgatttcta cctaactcat
      361 gatttttata aaaattatct tcctttaggt agtattttca tggattatag aaataatttt
      421 gaaaatgata agagtttaat agtctatggt cattatatga aaaataaaac tatgtttggt
      481 cagctagaaa actatactga tgaagtattt ttcaaagaaa ataatttagt agaaataaat
      541 tataaagtac aaacttatac ttatgaaatt ttttcagtat atactgctga cttaattaac
      601 agagattatt taagtataca ctttaataat aatgatgagt ttaaatattc tttgaattat
      661 ataacctaaa aatcagtaca caaatctgat ataaaggtag atatttcaga taaaattata
      721 actttgtata cttgtaaata tgaatttaaa gatgctctta ctatagttca tgctaaatta
      781 atttcaaaaa agagacctat aagtaggttt gtgtaaatgc agacttatct acagtctttt
      841 ttgaacgtaa aattggtaag tatagaataa tattcatatt aaacttttgt aggcaaagaa
      901 atgaaaaatc aaagagaaat aattattaca gatttagatt accaagctga attaagaaag
      961 tgtaaaacta tggaggatgt agttagtgaa gataatatat aatagtttaa cttataaatt
     1021 atcttggtga tattaatgaa gtttcaaagt atatattatt tattgatata aataaaatta
     1081 aatctgttgc taatagatgt acctttgttt ggagacaaac tattgaagaa atataactaa
     1141 aatgttgaag tagctacctg actttatttt gaaatgcgaa caagattttg gcattaagat
     1201 aatttagaaa gaatcactgg tacacaagga tgtgaactta gaatgaatag aagtattcag
     1261 gcataaggag ctttcaccca aataaaacat agtatgaact ttaaaagaat tctaatcaga
     1321 ggcaatcaag atattctttc agagtttata cctgtagtgt tagcctatag tatttctaag
     1381 tttcacaaat aagataatca ttaataaatg tagtatgtat attcatcctc tcaaaaatat
     1441 tttttaatct tacactttgt aaattattct attttaaaat ggtattttta tacctttatt
     1501 tcttatgacc gttttcaagc tcaaattttg cataaatata aattaatgaa aagcaagtaa
     1561 aaaaagaact gtcgcacagc aatttaaaat tactcattcg acagtcctta tttcgtggat
     1621 ttaaatagtg gagaagaatc acaagaataa tacccacgat taaaccttta tacaatacat
     1681 tttatatgac tttaccatca ctaatagtta ttatacaatc agccatctta gctatttcat
     1741 cattatgagt tatcataacc aacgtctgct tgtattcatt tacacaatac tttagtaaat
     1801 tcatcacctc attagttgtt ttactgtcta aatttccagt aggttcatct gcaaaaatta
     1861 ttgatggctt attggcaagt gatcttgcta ttgcaactct ttgttgttga ccacctgata
     1921 attcattagg aaatttatta atctgacttt ctaatcctaa cttagttatt aaatcattaa
     1981 tataattatt atctatcttt cctttagcaa ttaaaatagg aagaactata ttatcataaa
     2041 cattgataac aggtattaga ttatagtttt ggaatataaa cccaaattct ttacttctaa
     2101 gattagatag cttttcatca cttaaagtat ataaatctaa attatccata aatacattac
     2161 ctaaagttgg tttatcaagc cctgccatac agtgaagtaa tgtgcttttt ccagaaccac
     2221 tttgtccaat tattgcacta aatttatggg gttctatctc taaagtaatt ccatcaacag
     2281 cctttatttc attttctcct tttccatata tttttttaat atctataact tttaacatct
     2341 tcatacattt acctcccaaa ttattcattc tcttttatac cttcaataat attcatactt
     2401 tcaaaatctc tattacttac aactactgct attaaacata caaatacaga tatagcaaag
     2461 aatagtaaag attccttaat tgggaatgta aaagacataa aattctctat tccatagttt
     2521 atatacgcat cattattcca atttgtaaat ttaactagat ttataaatga tggaatcata
     2581 gctattataa agctaaaaac tgcatatgct aatgcttcat atataagcat ttttttcata
     2641 tttttaagac taacacctaa tgctctaagc gttgaaattt ctttttttct aattagtaga
     2701 tttgttctta tagtacagaa aatattaatt gatgctatta ttaaaactag tgcaattatt
     2761 gctatttgtg atttaatgta acttttatat atactttctg acatttcatg ataacttaat
     2821 ctactattaa atagagaccc tggtatactt cttgaaattt tctgtatctc attattaaca
     2881 atctcatcat atggattttc taaatttatg cctaattgag tgtatttttg ttctcctgtt
     2941 atgtttttag agtgaatatt acttgttata atttctagat ctggcataaa atcgccatct
     3001 cccatagcaa tccattcatc ctttaaaatt acagccactc ttaccttcat ctctttataa
     3061 acaattgtat tattttcttc aacaggaatt tttacagtta ttatgtctcc tatatttaat
     3121 tctttgaata taggctttat agtatgatca tcaactatat cataaaaata attatatact
     3181 gctacatttg gatatccatc agtgtccttt ttaatatcat ctaagctacc ttcttcaaca
     3241 aagtcattta acttttcatc tatataatca tcatcataaa gctttaaaac taatttatct
     3301 tccattatct cttttttttc tactccatta taggttgtaa attctttgtt tatatcctta
     3361 ttattaaaag taaacattcc atttgttatt tgaattttat gtatactttt aacaccctta
     3421 attttttcta tattctctac atcactatcc gtgtattttg atatttgcgg gtctgcattt
     3481 actccaaatt gcattgttat attatatcta ttttgcatat cttcaatttt actgttgacc
     3541 tcttcttgca tacttgagaa tgtagtaatg aatatatatc ctcctaaagc aatagacaac
     3601 atagatatag cagctctaac cttatttctt ccaatatttt taagtcccat aaatccataa
     3661 aatccaaata ttttgcttac tagtctgtct attccaagtc tacttctgtg atttttaatt
     3721 ttgtctgtat ttattattga ttcaataggt gatatcttgc cgattttaaa agttggtata
     3781 atacaagata taaaaacaga aattattcca accaatatag cttttataac tatttcatta
     3841 tttatatata atttagggtt aagaccagct tcactgtata aaacttcgtt ataattacta
     3901 attcctatat atgaatatgt aaccccagct actaacccaa gtagtatacc tattattgtt
     3961 ataattaatg cttgatagat tatcatacac cttacgtttc ttttctttgc acccatcagt
     4021 ctaaacagtc ccatttcttt tactgattga tttagtgtaa tattgaaaat attaaatatg
     4081 aaaattatag atactgtagt tattaaaaca tttcttttaa aaacattcgg atcattctta
     4141 tcatcttcta cataacgaag ttcccttaca agaggtacat ttggtagaaa acttttttgt
     4201 cctaacttat attttttcat aagataatca cattcacctt caatatttct ccatccactt
     4261 ttaaaactta atatactatt ataactaatc gcatcatgag gtataatgtt atttgtttca
     4321 tcattgccat aagttactgc ttcgtattgc caaaccacat catagtaccc ttttggtttt
     4381 tccataactc ctactatttt aaattcttta tttatagaaa ataatcgatt acttccgtta
     4441 gtatctttat agttcttttt tattgttaaa tttaatgtag atcctactcc ttcacttaaa
     4501 ttcattgctt ctagtgcttt tttctctaat actatttcat tgttgttttt aggtagtcta
     4561 ccttctatta ttttgttgta tctacttttt agatactctt cgtttgatga agttaatata
     4621 aatgagtttc cttttttatc tgaaatacgt cctaaatttt gtaccgaatt accctttgat
     4681 actttttcat cagtttctaa ttttttagca tcatcaagtg tcaaatcact aaactctaca
     4741 tggtatccac tgtaaagttc atgtattgct actacattgt tttcattttg tgaatctttt
     4801 ataacactag gtccaaatat caacataaca cctaacataa ctcctattat taaaagtagt
     4861 gttctaagtt tatttttctt taaatatgct agtgacattt ttaagtaaat ccccatataa
     4921 tcctcctatt ttactataaa ttatttatcc aactcatctg ttaagtagat tggtggatat
     4981 tttaaatctt ttaattcttc attatttttt gaagcttact accatcttcc tcatgataaa
     5041 cttgcagtat caccttattt acatgtagtg cataataatc accactataa aaatattggt
     5101 attcataacc tggataattt ttgtaaaatg atttataaag tacccatcct aattctcttt
     5161 tgtatacttt tcttttgtaa tacgctctat atcatcacct gaaactcctt gatatgtcat
     5221 atatttatct atatattttt cagcttcatt ccattttcta aaatagttgt tgtatataat
     5281 aaatcctatt atggctataa tgcttataat taaagttaat aaaatagctt tgtattttct
     5341 catagtgaat cttactactt caatttaaat tctttaataa gttttaattc taaagactta
     5401 gttttatcat caaatttctt aacttgaatt tttatatctc ccaaattatc aacctctata
     5461 tttccttcac ctttatcaaa tacttcttca atttttctaa aaaattcttt ctcacttatt
     5521 tctacatgaa tcaatgatct atatgttata aatagccatt atgaatttat catcttctga
     5581 cagtttttca ttataagaaa aatctttaac acattgaatt gataatattt cctttgtccc
     5641 cttcttgtcc ttagtcattg aataatgtaa aacttggcta ggttgttctt ttgtatactc
     5701 caagtttccc aaagacaaaa caaaacttcc atctgattta ttttcagcta ccctaagacc
     5761 actattttct attgattctg atattttctt tgacaagtct tcttgatact agaaatcggt
     5821 tcaatagtat atattttttc atttgtatct gaaaccttat ttgtgcatcc tgttattaaa
     5881 cctagcgtta agcttatagc tataaccata gttattgtaa tttttttatc ttcatataat
     5941 cccccttata tattgaaaac tcgttatttc tcataaaaaa aagacgctat ctttttctat
     6001 taaaagataa catccctata tgtttagtat caatatatgt tccccaactg gtaggttaat
     6061 cgacccaact atcaaaattt tgatttaatg gtatataaat attcaatata aatttgtctt
     6121 ttttatcttc aaatgataaa tctcctctat atttttttat agaagatttg atgctttaaa
     6181 tccctattcc atgtacaagt ttatcttttt tatctgttaa taataaactt ttattctttc
     6241 taattgaatt tattttacta ttctcacatt taattacgaa ataggacttt gagatagttc
     6301 cttttatttg tatatattta tcaatacttt tatcatgtat cttatcgcaa gcttctattg
     6361 cattatctaa gtatttgcaa atatattaga tacatctatt ggttttataa aattcacttt
     6421 ggaaaaattg atatcacaaa tgaatttaat ttttcttttt tcacttacat cacttttttc
     6481 atttattatt atatccaata taacattacc tgtattgtaa attgatttaa attctttaat
     6541 ttaatctttt aaactattta catacccatc aattttcctt ttttatattt gagattttct
     6601 atacaatata tatgattatt tatatcatga taaagcttct taactttagc gtgtgattct
     6661 tgaatactta gataatgaga atactgcata tctaacttat tttttattac ttcattttgc
     6721 aattttaact tattttcctt aattattttt ataaacacta taataatgac taagctacta
     6781 gatagtatta acctaggtat cacaatatac ccaactatat atatttccta atacccacca
     6841 aattgataca tttttctatt tatataaatt attaatatag taaataaatt tgttattaaa
     6901 gcaacagata agtatatata gtttatttta ttatctttat ctagtcccaa tcttttat
//
LOCUS       DAEQCW010000147         6927 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.148, whole genome shotgun sequence.
ACCESSION   DAEQCW010000147 DAEQCW010000000
VERSION     DAEQCW010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6927)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6927)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6927
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.148"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            121..963
                     /locus_tag="KRO40_003292"
     CDS             121..963
                     /locus_tag="KRO40_003292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBH2094088.1"
                     /translation="MKEKAGIRNAIIAAFIITILAELIGPISFKVMGINVTLLSILWA
                     IFIGMAVSPHLLGRVIPALKKFIGDNEINVSPYLLSLTLYPLGIMFGINAGPKVGILL
                     QAGPALLLQEFGHMGTMLIALPVGVALGLGRSALGGTFSLCRDTALGIIGDKYGLNSP
                     EGIGTLGTYISGSIFGTLLFSFLAPVGVLLGFHPYALAMASGMGSGSMMGAATASLMN
                     TVPQMSEQILAYSATSGLITAVTGIYIELFLSLPVANYYYSKVAPVIERFRGRKTRRT
                     SNKL"
     gene            978..1442
                     /locus_tag="KRO40_003293"
     CDS             978..1442
                     /locus_tag="KRO40_003293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094089.1"
                     /translation="MEKTFKTIMEQIKIVLFIYIIICFGQMIALKTQAQDLLIGSVSG
                     FLLVIIAIIIKNFVKKPNLPGFAWATLVAFVLSLPISPVGDIIATNVGKINFMSTVTP
                     LLAFAGISVGNQLDILKTLSWKLVVISFIVMTSTYFGSAFISQTVLRLNGML"
     gene            1429..2601
                     /locus_tag="KRO40_003294"
     CDS             1429..2601
                     /locus_tag="KRO40_003294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBH2094090.1"
                     /translation="MECFKEVVNMNELKAKIKEEIKLLSEEKKTSFEKVSDYLFSNPE
                     LAFEEYKSQKALCDLLEENEFNVTKGVGGLETSFEAVYSNGTNGKTVAFLAEYDALPG
                     MGHACGHNIIGTSSVGAGIILKEIMKKHNIEGTVKVFGTPAEERVGGKITMIKEGVFN
                     NVDAALILHPSDASMPDDISFAQVNLKFDFTGKASHAAAFPWEGKSALSGVIALFNSV
                     NSMRLHLKDYARVHGIITDGGSIHNIIPEKSTAIFNVRALSIEYLNEICEMLKNCAKG
                     AAISTGTNVEIVQLDEIYKEIKNDSELVNIVRQNFEVLGEDYVERDLSQGIGSTDTGN
                     LTHEIPAIQAYIKLKENTATHTDEFAVAAGGEEGRVALIKAIKVLAMCGVDILYSK"
     gene            2645..3580
                     /locus_tag="KRO40_003295"
     CDS             2645..3580
                     /locus_tag="KRO40_003295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1177 domain-containing protein"
                     /protein_id="HBH2094091.1"
                     /translation="MILKQVIEVYDILDKANANGEEVKTYLQGYGEVDVTVKELSSSK
                     GSTDLVKLTIPGKNGKLKGGDAPTLGILGRLGGIGARPEVIGFVSDGDGALVAIAVAA
                     KLLDMQRKGDILDGDVVISTHICPDAPTKEHYPTPFMDSPIDMMTMNENEVDSSCDAI
                     LSIDTTKGNRVINTRGFAISPTVKEGYILKTSDNLLDIMQTVTGKSPFVFPLSIQDIT
                     PYGNNLYHLNSILQPAVATDAPIVGVAITTEMPVAGCATGATNFSDLDSAGRFAIEVA
                     KLFGRNKCDFYDKEEWEMLIKRYGKLNRFQTFGIQ"
     gene            complement(3951..4676)
                     /locus_tag="KRO40_003296"
     CDS             complement(3951..4676)
                     /locus_tag="KRO40_003296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2094092.1"
                     /translation="MLESKIRTPEEIKRYMLDLKKWLAQERSKPVEEMSDFFSKRIDI
                     YDNVHLANWTEEYAHIADYFDTPLSSLLDIGCGTGLELASIYRKFPNVQITGIDLSKE
                     MMSKLKEKYSDKNIDLILADYFEYPFEQEKYDAALSFETLHHFKYQKKQKIYKKLFQT
                     IKPGGYYVECDYIACCLEEETICLEQYEFKCKENHVPDDVFVHIDIPLTIEHQIHLMK
                     NAGFRAVYVLHENNGTMIIKAEK"
     gene            complement(4694..5260)
                     /locus_tag="KRO40_003297"
     CDS             complement(4694..5260)
                     /locus_tag="KRO40_003297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2094093.1"
                     /translation="MPPKPIITKQDIINAAIQLVRENGISSVNARNLAKTLNCSTKPL
                     FRIYTNMDEIKEDIKIELDNYYNSFMESKINDENRLLSQGLAYIEFAQNEKMIFNTLF
                     MNMTMKGSSLQDIIHAKWNRITIENAKKVTGLSIEKSEMLFINFWLYSHGVATQIISN
                     GIDIPLDMVQQLLENAFERFSLDITKTE"
     gene            complement(6171..6569)
                     /locus_tag="KRO40_003298"
     CDS             complement(6171..6569)
                     /locus_tag="KRO40_003298"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HBH2094094.1"
                     /translation="MKWKELYNKARGKLNPRTISPFIDAGGVAAAILTDSGNVYTGVC
                     IDTACTLGMCAERNAIANMITNGESKITKLVCVMSNGSVGSPCGACREYLMQLDKDSA
                     CIEILVNVETEKTVKLSELLPDWWGSDRFI"
BASE COUNT         2386 a         1021 c         1237 g         2283 t
ORIGIN      
        1 taaaagtata taaaaatgat gaataaatat atattataca ttatcaatga taggttatat
       61 aataaaatca ctaacaatta tattataaga aaattataaa aattacaagg aggtatagaa
      121 atgaaagaaa aagcagggat tagaaatgcc ataatagcag cctttataat cacaatattg
      181 gcagaattaa ttggacctat ttcatttaaa gttatgggaa ttaatgtaac tttacttagt
      241 atactatggg ctatattcat aggaatggct gtttctcctc atttattagg gagagttata
      301 ccagccttaa aaaagtttat aggggataat gaaataaatg tatctccata tttattatct
      361 ttgacactat atccattagg gataatgttt ggaattaatg cagggcctaa agttggtata
      421 ttacttcaag caggaccagc acttttatta caagaatttg gtcatatggg tacaatgttg
      481 atagcattac ctgttggagt agcattaggt cttggaagaa gtgcattagg tggtactttt
      541 tcattatgtc gtgacacagc actaggaatt attggagata agtatggatt aaactcacca
      601 gaaggtatag gaacactagg aacttacata agtggtagta tatttggaac attattattt
      661 tcatttttag caccagtggg tgtactttta ggatttcatc catatgcttt agcaatggca
      721 tcaggaatgg gtagtggttc aatgatggga gctgcaacag catcattaat gaatacggtt
      781 ccacaaatgt cagagcagat tttagcatat tcagctacta gtggattgat tacagctgtt
      841 actggaatat atatagaatt attcttatct ttaccagtag ccaactacta ttatagcaaa
      901 gtagctccag ttattgaaag atttagagga agaaaaacaa gaagaacaag taataaattg
      961 taaaggagga tatatatatg gaaaaaactt ttaagactat tatggagcag ataaaaatag
     1021 tattgtttat atatattatt atttgctttg gacaaatgat agcacttaag actcaggctc
     1081 aagatttgtt gattggaagt gtatctggat ttttgttggt gataattgct attataataa
     1141 agaattttgt taaaaaacct aatttaccag gttttgcatg ggctacatta gttgcattcg
     1201 ttttatcgct tccaatatct ccagtggggg atatcatagc aacaaatgta gggaaaatca
     1261 attttatgtc tacagtaaca ccattattag cttttgcagg aatctctgta ggtaaccaat
     1321 tagatatatt aaagactttg agttggaagt tagtagttat atcatttata gttatgacat
     1381 ctacttactt tggttctgct tttatatctc aaacagtttt aagattaaat ggaatgcttt
     1441 aaggaggtag taaatatgaa tgaattaaaa gcaaaaatta aagaggaaat aaagttatta
     1501 tctgaagaga aaaagacatc atttgaaaaa gtttctgact atttattttc aaatccagaa
     1561 ttagcatttg aggagtataa gtcacaaaaa gcattatgtg atttgttaga agaaaatgaa
     1621 tttaatgtaa ctaaaggtgt aggaggatta gaaacatctt ttgaagctgt gtattcaaat
     1681 ggaactaatg ggaaaacagt tgctttttta gctgaatatg atgcacttcc aggaatggga
     1741 catgcatgtg ggcacaatat catagggaca agttctgttg gtgcaggtat catattaaaa
     1801 gaaatcatga aaaaacataa tatagaaggg actgtaaagg tttttggaac acctgcagaa
     1861 gaaagagtag gtggaaaaat aactatgatt aaagaaggtg tatttaataa tgtagatgct
     1921 gcattaattt tacatccaag tgatgcttca atgcctgatg atatatcatt tgctcaagtt
     1981 aatttaaaat ttgattttac tggtaaggca tcacatgctg ctgcttttcc ttgggaaggg
     2041 aaaagtgcct taagtggagt aatagcacta tttaacagtg taaatagcat gagattacat
     2101 cttaaagatt atgcaagagt acatggaatt ataactgatg gaggtagcat acataatata
     2161 attcctgaaa aatctacagc tatatttaat gtaagagcct taagtataga atatttaaat
     2221 gagatttgtg aaatgcttaa aaattgtgct aaaggagctg caatttctac tggaactaat
     2281 gtagaaatag ttcaattaga tgaaatatac aaagagatta agaatgattc tgaattagtg
     2341 aatatagtta gacaaaattt tgaagttttg ggtgaagact atgttgaaag agatttaagt
     2401 caaggtatag gttcaactga tacaggaaat ttaactcatg agatacctgc aatacaagca
     2461 tatataaaat taaaagaaaa tactgcaact catacagatg aatttgctgt tgcagctggt
     2521 ggtgaagaag gcagagtagc acttataaaa gcaattaagg tgttagcaat gtgtggagta
     2581 gatattttgt atagtaaata atatataatt ttaaaatata ttaagaaagg aaatcggatt
     2641 agacatgata ttaaaacaag taatagaggt ttatgacatt ttagataaag caaatgctaa
     2701 tggggaagaa gtaaaaactt acttacaagg ttatggtgaa gtagatgtaa ctgtaaaaga
     2761 attgtcttca agtaaaggct caacagattt agtaaagctt acaattcctg ggaaaaatgg
     2821 aaaattaaaa ggtggagatg ctcctactct tggcatttta ggtagactag gagggattgg
     2881 agcaagacca gaagttatag gttttgtttc agatggtgat ggagcattgg tagcaattgc
     2941 agtggctgct aaacttttgg atatgcaacg aaaaggggat atattagatg gtgatgttgt
     3001 aatttcaacc catatttgcc cagatgctcc aactaaagaa cactatccta ctccttttat
     3061 ggattctcca attgatatga tgactatgaa tgaaaatgaa gttgatagta gttgtgatgc
     3121 aatactttct atagatacta ctaaaggaaa tagagtaatc aatactagag gatttgcaat
     3181 atcgccaact gttaaagaag gctacatatt aaaaactagt gataaccttt tagatattat
     3241 gcagactgta acagggaaat ctccatttgt attccctttg tctattcaag atataacacc
     3301 atatggaaat aatctgtatc acttaaatag tattttacaa ccagcagtag ctacagatgc
     3361 accaatagta ggagtagcaa ttacaacaga gatgcctgtt gctggatgtg ctacaggtgc
     3421 aactaatttt agtgatttag attcagctgg gagatttgca attgaagttg ccaagctatt
     3481 tggtagaaat aagtgtgatt tctatgataa agaagagtgg gaaatgctta ttaagagata
     3541 tggcaaatta aatagatttc aaacatttgg tatacagtaa ttagaaaaat attaagttta
     3601 tataatttgt gatataaata tctatactat gtaaacaact agaaacaaaa gatatagttt
     3661 aagacttaaa aaataaaata tttatttgat tacataaata aggagtgttc tatttaggta
     3721 agcgccaata agtagtataa cattaaagct aacctaattg ttgatataca agattgaaat
     3781 gaaaacagtg cgtattataa gaaaaggtta cgcactgttt ttttcgtcct gttatatagc
     3841 agaacactag tttttaaggg tatgagtata aaactttttt aaatttcata tctacgaatt
     3901 ttgtagattg tccataagcg atatgcaata attaggaaaa tattttgagt ttatttttca
     3961 gctttaataa tcattgtgcc gttgttttca tgaagtacat acacagctct aaagcctgca
     4021 tttttcatta agtgtatttg atgttcaata gtcaaaggaa tatcaatatg gacaaaaaca
     4081 tcatcaggca catgattttc tttacattta aattcatatt gttcaagaca aattgtttct
     4141 tcctctaaac aacaggcaat ataatcgcac tcaacataat atcctccagg tttaattgtt
     4201 tgaaaaagct ttttatatat cttctgcttt ttctgatatt tgaaatgatg aagcgtttca
     4261 aatgagaggg cagcatcata tttctcttgc tcaaaaggat attcaaaata atctgccaag
     4321 attaaatcaa tatttttatc tgaatatttt tctttaagct tactcatcat ttcttttgat
     4381 aaatcaatgc ctgtaatttg tacattagga aattttcgat aaatcgatgc aagttctaga
     4441 ccagtaccac aaccaatatc aagtaaagaa gatagtggag tatcaaaata atctgctata
     4501 tgtgcatatt cttctgtcca attagcaaga tgaacattat cataaatatc aattcgcttt
     4561 gaaaagaaat ccgacatttc ttcaaccggt ttacttcttt cttgcgctaa ccattttttg
     4621 aggtcaagca tatatctttt gatttcttca ggtgttctta ttttactttc caacatataa
     4681 aacagtcctt tctttattcg gtctttgtta tatccaatga aaatcgctca aaagcatttt
     4741 caagtaactg ttgtaccata tctaatggaa tgtctatgcc attggaaata atttgtgtag
     4801 ctactccatg agaataaagc caaaagttaa taaatagcat ttctgatttt tctatagata
     4861 agcctgtaac ttttttagca ttttctatag taattctgtt ccattttgca tgaataatat
     4921 cttgtaagga tgaacccttc attgtcatat tcataaataa ggtattgaaa atcatttttt
     4981 cattttgagc aaattcaatg tatgcaagtc cttgacttaa cagacgattt tcatcattta
     5041 ttttactttc cataaaagaa ttatagtaat tgtctagttc tattttaata tcttctttta
     5101 tctcatccat atttgtgtaa atacgaaaaa ggggttttgt agagcaatta agggtttttg
     5161 ctaagttacg agcatttacg ctacttattc cattttctct taccaactga attgcagcgt
     5221 taataatatc ttgttttgta ataatcggtt ttggtggcat cttttcatcc tcctttcggt
     5281 aacttaagtt gcgcaactgg tgttgttatt ataacaaagg catataactg tgtcaataga
     5341 cttcaaagaa aagctacaga catcgagtgt aatatgattt atttcaataa ataccataat
     5401 atgtgtactt atatcttaaa aaggagataa acagtaaaat gtagtttagt taaatttgaa
     5461 acttcgtcaa agcttctttg tacgataaga caacgtacaa atcattgtat gggtaacaga
     5521 gaaagaactg cgttgattga ggatgaaatc tcacatgata cgatgtaatt ataaaaaaag
     5581 gagcgtttca aagtgatttt tttaatcatc ttgagacaac tccttatatt ttttatttaa
     5641 attctatttt ttattgcctg tatagctatt ttctccatca taaggtggca tgaccttgaa
     5701 cagcgtggtt ttgtaaagtt gggcaccaca aaacaaaaaa tcaacaagcc cttgtgtggt
     5761 ctgctgacgt gtttactata ctatacttta tccaaaaccg caagcactat gggaggctat
     5821 aaggcggcgg ccattcaggg gcgatcccct cgaaaccggg atagggttcc catgtgggac
     5881 ataataaaga gcgccccgga ggtatcaact agcatctggg gcgctcttta ttatgccccg
     5941 tgggaaccat gcccacgaag cagggcgtac aacggacaga taggtcctac cctcctgaca
     6001 aactggaatc tccgaaaaca atcataacaa tcatggcaag attatataca ctcctgtaaa
     6061 atatttttgt gtgtaccatg aagtactgct tgccactatt gagaacggat aaaagggaag
     6121 tacgtattat accaataagg tgcatgaaac aaaatactca tttgataaag ttaaataaac
     6181 ctgtcggaac cccaccaatc cggcaaaagc tcactcaatt taacagtttt ttctgtttcg
     6241 acattaacta aaatctcaat acaagcacta tccttatcaa gttgcattaa atattcacga
     6301 caagcaccac atggtgagcc aacactccca ttgctcatca cacaaactaa tttagtaatt
     6361 ttactttcgc catttgttat catattggcg atagcatttc tttctgcaca cattcccaat
     6421 gtacaggctg tatcaataca cacaccagta taaacatttc cgctgtcggt aaggattgct
     6481 gcggcaaccc caccagcatc gataaaaggt gaaattgtgc gtggatttaa ttttccccta
     6541 gccttattat aaagttcctt ccatttcatc aggttgatcc tcctgttgta tccatataaa
     6601 taatctttta tacgcctttt ccgcctaagg cacacaacac attactcgct tttttcattc
     6661 taatattcgt gcgtgaaaat gtcaaacggt ttacttcgtt tcattacttc atactgctgt
     6721 tcataaccct gtttgttcac ttgggcacca ttagagcacc aatttacccg tttcagggtt
     6781 gtagcgaaca cagcagaaat gctcatttca tgggcttttc tggctagaaa aaaaatttta
     6841 tcgctgccag atatttacta ttttttatta agttgctgga gttccactac catcaggagg
     6901 agtagtagag ccaccaccat tatttcc
//
LOCUS       DAEQCW010000148         6765 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.149, whole genome shotgun sequence.
ACCESSION   DAEQCW010000148 DAEQCW010000000
VERSION     DAEQCW010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6765)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6765)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6765
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.149"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(441..2828)
                     /gene="cadA"
                     /locus_tag="KRO40_003299"
     CDS             complement(441..2828)
                     /gene="cadA"
                     /locus_tag="KRO40_003299"
                     /EC_number="7.2.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase"
                     /protein_id="HBH2094095.1"
                     /translation="MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFIN
                     KKLTVNIKESFNEDTTIEKIIDIIDSTEPGLDIQISSKENAASKTSIKKELILGGLNC
                     AHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD
                     IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVF
                     IVAYVIVGGDVLLRAIRNISKGRVFDENFLMALATVGALTIGELSEAVGVMLFYKVGE
                     YLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVGDIIVVKPGEKVPLD
                     GVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKIL
                     DLVENSSIKKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIF
                     LVVSCPCALVLSIPLSFFSGIGFASKNGILIKGSNYLEALRSVDIVVFDKTGTLTKGV
                     FNVTKLNPEGISEEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYEEIAAYG
                     IRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKVYRGYIVISDEVKEDSK
                     NAIRSLKEIGVKEVVMLTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRT
                     EKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMTDEPSKISKAIEIA
                     NKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR"
     gene            complement(2851..3216)
                     /locus_tag="KRO40_003300"
     CDS             complement(2851..3216)
                     /locus_tag="KRO40_003300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2094096.1"
                     /translation="MREEINDCNCNIVHEEIVTEAKSTMPDEEMLYDLAELFKVFGDT
                     TRVKILYALFANEMCVCDIASLLNMTHSAISHQLRVLKQARLVKFRREGKTVYYSLDD
                     SHISQIFDCGLNHIRETYK"
     gene            3415..4263
                     /locus_tag="KRO40_003301"
     CDS             3415..4263
                     /locus_tag="KRO40_003301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094097.1"
                     /translation="MSNKKKKDLDTSYMPYLDPANYADYITNEEIPQDELRNDPQISN
                     GYTKIPNNQNINNLYPNNVNHYPKSSNSPNNLPNTNNTSGNMNYNTSATNNMPNNMNN
                     NTGMPNNMSNNMNSNMGMPNNMPNNMNSNMGMPNNMPNNMNSNMGMPNNVPNNMNSNM
                     GMPNNMSNNMNSNMGMPNNMSGNMNNNMYGNTGMPNNMNSNMGYNMNNTMGIPNFSCN
                     QNMPPNVLMMIPGVICHNTMQGMPVVMPSTMPPNIYPTPYGSSNMSVQGIPQATNIEE
                     FDEEEM"
     gene            complement(4700..5788)
                     /locus_tag="KRO40_003302"
     CDS             complement(4700..5788)
                     /locus_tag="KRO40_003302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094098.1"
                     /translation="MNFNFAKATNSRLMGSLGLIINWIDDENNHFCQYFLLDAEGLGL
                     ADYVSLNNPTQEEAYMEEERLMGGFGSDRVELTKDESLFLVSYFGNKNLYYDKLLPGD
                     KCEYIDIIKNYKTDLTIEKLYNKICKRVDEEVEFINYMTMRFIAWDRESLKYFSGSDE
                     IANMHITNINGTLLKNVVSDKGQGRYISEALYEDNDGYYICKIAFCISKCYETGFRIN
                     SLLVTDKEPMYDFEVFDEISKSEFVSVYSVNSPEEFAGVFYRENPFLLKSNMNEGIFF
                     TRFNFNNDHVKENVYIINNDMKAIYYLMGNKFFIGTYNENDCNYINEISQSNYSDYIK
                     FEEKFFFEQNALYDFAESGSLDFDDFLE"
     gene            5913..6641
                     /locus_tag="KRO40_003303"
     CDS             5913..6641
                     /locus_tag="KRO40_003303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBH2094099.1"
                     /translation="MKNIAAFFDIDGTLYRDSLMVEHFKKLIKYDIIDQKNWYKHARD
                     TFMDWDKRQGNYDDYLLEICDLYVDSLKGLDKTCINFTSDQVIKLKADRVYKYTRSRI
                     EWHLNQGHIVIFISGSPGFLVEKMAKKYNVTDFLGSDYVFENNIFTGTVIPMWDSISK
                     NNAINDFVVKYDLDLSNSYAYGDTNGDINMLKRVGNPIAINPTKELLSQISLDEEISK
                     NVEIIVERKDIIYSLSTDVNIVDI"
BASE COUNT         2380 a         1119 c          730 g         2536 t
ORIGIN      
        1 cttaaaaata attcgtcaat actttttaaa attatttttt aaaaatattt actttcttat
       61 attacataat ttattgaatg gcagtcatac tgttggttta gagtatttta acacacacat
      121 tttgttgtaa aaattacaac tattaatata atatatatac aatcataagt attataattt
      181 ttatgaatct aatttaaact taatataaac ttattaataa accttctatg tctaaatttt
      241 aaaattacaa tataaaagct ctacactaaa taaatacatt aaataaacat aatggataat
      301 gaatataaat ttatatatgc aaagcgctcc aataaaaagg taccaataaa gttaaaagaa
      361 acttattgat acctttcatt attacatact tcaatatata attataagtt ttttaaatag
      421 tatggattta catttatccc ttatctcata gctctcatag catttactac tgctataagt
      481 gccacaccta catcagcaaa tatagcttcc cacatagtag ctactcctcc agcacctagt
      541 atcataacta taatttttac tcctagagca aatattatgt tttgccacac tatcttatta
      601 gtcttgtttg ctatttcaat tgctttagat atcttgctag gctcatctgt cataagcact
      661 acatctgcag cttcaatagc agcatctgaa cctaagcctc ccatagctat accaacatca
      721 gcacgagcta atactggagc atcatttatt ccatcaccta caaacgctat tttctctttt
      781 tcagttcttc cttcatataa atcttctaat ctatctacct tttcattagg aagtaaattt
      841 gagtaaactg tatccaattc taattcttga gcaatatttt ttgctacttt ctcattatct
      901 ccagttaaca ttacaacttc ttttacccct atttctttta agcttcttat ggcattttta
      961 ctatcttctt ttacttcatc agagataact atataacctc tatatacttt atcaacagca
     1021 atatagacta ctgtgcctac ttctttagct gatgaataag atatattttc ttttttcata
     1081 agtttctcat tacctgctaa tataaaattg ccattatgct ttactctaat tccataagct
     1141 gctatttcct cataactgtc tattgtatct aaatcaattt ttttattata gtaacttaat
     1201 atggactttg ctattggatg atttgaattt acctccgcaa tagctgcata ttctaataat
     1261 tcttcttctg atataccttc aggatttaac ttagttacat tgaacacacc tttagtaagt
     1321 gttcctgttt tatcaaatac tactatatct acacttctta aagcttctaa atagttactt
     1381 cctttaataa ggataccatt tttagatgca aacccaattc cactaaaaaa actaagtggt
     1441 attgataaaa ctaatgcaca agggcaagaa acgactaaga atatcaatcc tctatataac
     1501 caatcactaa atacctcacc tgagattaca agtggtggca caaatgctat taataaagca
     1561 gctattacta ctattggagt atagtatctt gaaaacttag atataaagtt ttctgtcttt
     1621 gattttttaa tgctagaatt ttcaacaagg tcaagaatct tagaaactgt tgattctcca
     1681 aaactctttg taacttcaat actcaataaa gcatttttat ttataacacc tgataagatt
     1741 tcatctcctt tttcaacttc tctcagcact gactctcctg tgagtgcaga agtatctaac
     1801 atagaaactc catctactac tacaccatct aatggtactt tttcaccagg ttttactact
     1861 attatatcac ctacatttac ctcttctggt gacaccacct taacttcaga attaactttt
     1921 agatttgcat agtctggtct tatttgcata agtgaagtta tagactttct ggatttacca
     1981 actgcaacac cttgtaaata ctctcctact ttatagaaaa gcataacccc tactgcttct
     2041 gataactccc ctattgttaa tgctcctact gttgctagag ccatcaaaaa gttctcatca
     2101 aatactcttc cttttgatat atttcttatt gctcttaaaa gcacatcacc acctactatt
     2161 acataggcaa ctataaatac tatattgcta aactgacttt cataacctgt agctgtttga
     2221 tatataccaa atatatatac aagtgctcca attataagtg gaattaattc tttcttattt
     2281 gtatcattta cagctcctga tttttcagta gttctccctt ttactttgtc agtagaccct
     2341 acttgtatat caagccctgg ctctgttgaa tttattattt cttttatttt atttataaca
     2401 tcatcctctt caaagttatt acttatattt actgtaagtt ttttatttac aaagtttaaa
     2461 ttagaagatt caacttcttt taatttagaa actttgttat taatctcttc tgcacaatga
     2521 gcacagttta atcctcctaa tataagctct tttttaattg atgttttact agctgcattt
     2581 tctttagaac ttatttgtat atcaagacct ggctctgttg aatctattat atctattatc
     2641 ttttctatag tagtatcctc attaaaactt tcctttatat ttactgtaag ttttttattt
     2701 ataaaattta aattggaaga tttaacttct tgtagtttag aaactttatt attaatctcc
     2761 tctgcacagt gagcacaatt taatcctcct agtataaatt cttttttaat tgaattattt
     2821 gcttccatat atattcactc ctctcattta tcatttataa gtctctctaa tatgatttaa
     2881 tccacaatca aatatctgac ttatatgact atcatctaat gagtaataca ctgtttttcc
     2941 ttctcttcta aactttacta atctagcctg ctttaatact ctaagttgat gagatattgc
     3001 agaatgagtc atatttaata aactcgctat atcacataca cacatttcat ttgcaaataa
     3061 tgcatataat atctttactc tagtagtatc cccaaatact ttaaataatt ctgctaaatc
     3121 atataacatt tcttcatctg gcatagttga tttagcctct gttactattt cttcatgtac
     3181 tatattacaa ttacaatcat ttatctcttc tctcattttt aatcctccat tattttaata
     3241 tatgaataac tgttcatatg ttcattatat gttatcattt ctaaatttgc aacaataatt
     3301 tttattaatt taatataaat agaatgcaca tattataaac ttttttaata tatatattat
     3361 tagaataagt ttttgtaaac ttttttatag ttttctagga ggtgcaagtt taatatgagt
     3421 aacaagaaaa aaaaggattt agatactagt tacatgcctt acttagatcc agcgaactat
     3481 gcagattata ttactaatga agaaattccc caagatgaat tgagaaatga ccctcaaatt
     3541 tctaatggtt atacaaaaat acctaataac cagaacataa ataacctata tcctaataat
     3601 gtaaatcatt atcctaaaag tagtaattct ccaaacaact tgcctaacac aaataataca
     3661 tccggaaata tgaattacaa tacatctgct acaaataata tgcctaataa catgaataat
     3721 aatacgggta tgcctaataa tatgtctaac aatatgaata gtaatatggg tatgcctaac
     3781 aatatgccta ataacatgaa tagtaatatg ggtatgccta acaatatgcc taataatatg
     3841 aatagtaaca tgggcatgcc taacaatgtg cctaataaca tgaatagtaa tatgggtatg
     3901 cctaacaata tgtctaataa tatgaatagt aatatgggca tgcctaacaa tatgtctggc
     3961 aatatgaata acaatatgta tggtaataca ggtatgccta ataacatgaa cagtaatatg
     4021 gggtataata tgaacaatac tatgggtatt cctaacttct catgtaatca aaatatgcct
     4081 cctaatgtac ttatgatgat accaggagtt atatgtcata atacaatgca aggtatgcct
     4141 gtagttatgc ctagtactat gcctcctaat atatatccta ctccttatgg ttctagtaat
     4201 atgtctgtac aaggtatacc acaagctact aatattgagg aatttgatga ggaagaaatg
     4261 taatatatat ttttttaagt aagttgtata aaacattaat aattgaccat aataataaat
     4321 gtattcctca taatattccc ccaatattat tataggtata gaaagttgac tgaatatgcg
     4381 cttattcggt caacagatat taacataatc taataagata aacatagaaa aagtcagata
     4441 aaatttaatt ttatctgact ttttcattta aaaatgctct cttgtgttgg tgattcagaa
     4501 tagtatggta ctcgtatttg agactaatat tggcaaacaa cataaagaaa aatataaatt
     4561 ttttataata aactgtataa aattttaata attgaccaca ataataaatg tattcctcat
     4621 aatattcccc caatattata gaaataaatt taagcgagat taaattcagt taatctcgct
     4681 taaataatgt ctaaatttat tattccaaaa aatcatcaaa atctaatgaa cctgattctg
     4741 caaaatcata taatgcattt tgctcaaaga aaaatttctc ttcaaattta atatagtcgc
     4801 tataattaga ttgacttatt tcattgatat aattgcaatc attttcgtta taagtaccaa
     4861 taaaaaactt atttcccatt aagtaatata tagctttcat atcattattt attatatata
     4921 cattttcttt tacatggtca ttattaaaat taaatctagt aaagaatata ccttcattca
     4981 tattactttt taacagaaat ggattttctc tataaaatac tcctgcaaat tcttcaggtg
     5041 aatttacact gtaaacactt acaaattcac ttttagaaat ctcatcaaat acctcaaaat
     5101 catacatagg ttctttatct gtcactaata gagaattaat tctaaaacca gtttcataac
     5161 acttacttat gcaaaaagca attttacata tataatatcc atcattatct tcatataaag
     5221 cttcacttat atatctgcct tgacctttat cacttaccac gtttttaagt aatgttccat
     5281 ttatattagt aatgtgcata tttgcaatct cgtcacttcc agaaaagtac tttaaacttt
     5341 ctctatccca tgctataaat ctcatggtca tatagtttat aaattcaact tcctcgtcaa
     5401 ctcttttaca tattttattg tataattttt ctatagttaa atctgtttta tagtttttta
     5461 taatatcaat atactcacat ttatctcctg gcaatagctt atcataataa agattcttat
     5521 taccaaaata agatactaaa aataaagatt catccttcgt taattcaact ctatctgaac
     5581 caaatcctcc catcaatctt tcttcttcca tataagcttc ttcttgtgtt gggttattta
     5641 aactcacata atccgctaat cctaatccct ctgcatctaa taaaaaatat tgacaaaagt
     5701 gattgttttc atcatctatc caatttatta taagacctaa actgcccata agtctagaat
     5761 ttgtagcctt tgcaaaatta aaattcatat agtcacatcc tttaaactct aaaatacttg
     5821 ttttttaata tataaattat tatacatata ttttaacaac ttagatacaa tttataatat
     5881 aatataagga aatgattaat tgaggtggtc ttatgaaaaa tatagcagct ttttttgata
     5941 tagatggtac tctttataga gactctctta tggttgaaca ttttaaaaaa ttaattaaat
     6001 acgatataat tgaccaaaaa aattggtata aacatgctag agacactttt atggattggg
     6061 ataaaagaca aggtaattat gatgattatc tattagaaat atgtgacctt tatgttgatt
     6121 cactaaaagg attagataaa acctgtatca actttacaag tgaccaagta attaaattaa
     6181 aagcagatag agtttataaa tacacacgtt caaggattga gtggcatcta aatcaaggac
     6241 acatagttat atttatatct ggtagccctg gatttcttgt tgaaaaaatg gcaaaaaaat
     6301 ataatgtaac cgattttcta ggaagtgatt atgtctttga aaacaatata tttacaggca
     6361 cagttattcc aatgtgggat tctataagta agaataatgc tataaacgat tttgttgtaa
     6421 agtatgattt agatttatca aactcgtatg cctatggaga tactaatggt gatataaata
     6481 tgctaaaaag agttggaaat ccaatagcaa taaatccaac aaaggaactt ttatctcaaa
     6541 tatcacttga tgaggaaatt tctaaaaatg ttgagataat agtagaaaga aaagatatta
     6601 tttattctct atctacagat gtaaatatag tggatattta atttatacta tctattttaa
     6661 aaacttatat tatatctaat atttatatct aacatataaa agctttgact aaaaatcaaa
     6721 gcttttatat gttgcactaa gaatatatta aatttagctt tatgc
//
LOCUS       DAEQCW010000149         6757 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.150, whole genome shotgun sequence.
ACCESSION   DAEQCW010000149 DAEQCW010000000
VERSION     DAEQCW010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6757)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6757)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6757
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.150"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..269)
                     /locus_tag="KRO40_003304"
     CDS             complement(<1..269)
                     /locus_tag="KRO40_003304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094100.1"
                     /translation="MSKIECLFTIFPVLILMYATFYFMPYFVGKKHIYGVSIDQEHKN
                     YNYFIKLDKEFKKLLSLGFIIDFILVFILVFTFNKLELSYFIGIIG"
     gene            complement(262..651)
                     /locus_tag="KRO40_003305"
     CDS             complement(262..651)
                     /locus_tag="KRO40_003305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2094101.1"
                     /translation="MVLNLDFNSDKSIYVQIKEEITKAIASGELKINESLPSVRSMAE
                     NIGVNLHTVNKSYNELKEEGFLNIDRRKGAIVAQLPMKIDNTTRQKNKLDLELLVAKS
                     YLSGISKEEFLSLSSSLFDKYEVKYYE"
     gene            843..1289
                     /locus_tag="KRO40_003306"
     CDS             843..1289
                     /locus_tag="KRO40_003306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094102.1"
                     /translation="MLTYLMKRQMHKKDDGMSKPMMITGAVITGVGAYAVYKMVKSHK
                     SNSQMVNTNYYGNSDYDDYKYDEFDYDCDCRDTKQDYEYEELKKKVKEFNSRRINCEN
                     CPHVSQEEMMQYVNSVKDVKEEIDLHEDAKKDNIYKEDEYKKYEEE"
     gene            1553..2278
                     /locus_tag="KRO40_003307"
     CDS             1553..2278
                     /locus_tag="KRO40_003307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094103.1"
                     /translation="MKRKEIVMLKLLIVEDDSTISFGIKYALEQEGFSIDISKDLSSG
                     KEMISSNEYSMILLDVTLPDGTGYELCQYIRGFSQVPIIFLTACDEEVNIVMGLDIGG
                     DDYITKPFRIRELISRIKAVLRRKGNTSEENKKILKFGDLSIYTLEARVYKNDKEIFL
                     TSVEYKLLLILIQNKNTVLSRTQILEKLWDVTYDFVNDNTLTVYIKRLREKIGDDLCE
                     PIYIETVRGIGYKWIGSENSVSI"
     gene            2265..3509
                     /locus_tag="KRO40_003308"
     CDS             2265..3509
                     /locus_tag="KRO40_003308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2094104.1"
                     /translation="MFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRN
                     NQAIIGTLSSKYPNLESQIVDIITQGKSMENIDYGQKILIKYNYDKSIRINSEPIISK
                     LVLETIKINIILVCIIFILIFVLVVRYFKSIYNDLSDMTKYVYYSSEGKPFDMKNKNQ
                     EGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLY
                     NDVPYEVKIDFLNKIKNQLNRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAML
                     SMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNCVEHTPEFGNIIITYKEN
                     PLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIY
                     VNSEKGQGTEFHIIFHKMYDSD"
     gene            3589..4266
                     /locus_tag="KRO40_003309"
     CDS             3589..4266
                     /locus_tag="KRO40_003309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094105.1"
                     /translation="MEILRVENLTKSYGKNETKVDAIKNVSLSVEKGTFIAITGPSGS
                     GKSTLLHLLGGVDRPTSGKVYINDVDIYNLKTKDLAIFRRRNIGLIYQFYNLIPVLNV
                     KENILLPAELDNRDIDREYFDDLMKTLGLIDREKHLPNQLSGGQQQRTSIGRALINRP
                     SIILADEPTGNLDSKNSKEILELLKLSVKKYNQTLIMITHDKNMALQADRIISIEDGI
                     IKSDEVM"
     gene            4267..>6757
                     /locus_tag="KRO40_003310"
     CDS             4267..>6757
                     /locus_tag="KRO40_003310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094106.1"
                     /translation="MNLYTLLTIRYLKQNKRRTIVTIIGIILSTALICGIGNIFESFM
                     DYQMRETIKNDGSFHVTFYDVNRKNVEYVTKSAEIEKHAFTKQLGYSKLENSENAILS
                     IKQYDKNAINGYKVSIKEGRFPAKEGEIVLSESIINLIDDKLKIGDKITLKVGDMFDS
                     SKKKIDSMTFHEGDYIANEKDRTFKVVGIIEKPGFERYNGIATAIAYFNPMNNYNDTI
                     NVSVAVRNPKDVYKISNKISKNIYSNKDKEAVSDMIKYNEHLLRLQGASKYSNINNSI
                     KSIIIAVTILVIICTIATVYNSFSISINERKKQFGILNSIGATSSQIKRLVFIEGIII
                     SLIGIPIGLISGTVAIDLLFKIINKYFTESVVTKMSLQIVYNPIITIVSIIIVLLTIF
                     ISILLPAISASNISHLNVIKNTGEYKVGKIKSSRLIKMIFKTEGVLAYKNIRRNRKKF
                     IITLFSLMVSIIIFISFSGFTLLLLRGEEIRNSQRKYDLYLTAKNTARSVEDTISELE
                     DIDGIKNFELATGQYVSIRVSENKINKSKEDLIRKYYQKYKIGDSYEYDFSNNELIFP
                     GDFAVKNKINNLVQGSFNKERAIEENGVILVRKSAFEENGKKGVVELTNYKVGDTVNC
                     EYLDENALSKKVKVKILAITDEERLGLGYQNMGLQFITYDEVAKNLNLKLSKSLIFID
                     SGGSIKTKKEIEALANKNNFNFYDESASNESEKQDLKVIKIFVYGFIVVISLVSVTNI
                     LNTVSTSINLRKRELAVIQSIGVTPKGFRKMIYLESFIYGILSLLFGIPISIGIILIM
                     NKLISGVIEFSPIIPWTAIVICIVSVFIITFI"
BASE COUNT         2808 a          659 c         1087 g         2203 t
ORIGIN      
        1 cctataatac caataaaata ggaaagttcc aatttattaa atgtaaagac cagaataaaa
       61 actaatataa agtctataat aaaacctaaa gataatagtt ttttaaattc tttatctaac
      121 tttataaagt aattataatt tttatgctct tggtctatag aaactccata gatgtgtttt
      181 ttacctacaa aatagggcat aaaataaaat gtagcataca tcaaaattag aactggaaat
      241 attgtaaata gacattcaat cttactcata atatttcacc tcatacttgt caaataaact
      301 tgaacttagt gacaaaaatt cttctttact aatacctgat aaataagatt ttgccaccaa
      361 taattccaag tcaagtttat ttttttgacg agttgtatta tctattttca ttggtagttg
      421 agctacaata gcaccttttc ttctatcaat atttaagaat ccctcttctt ttaattcatt
      481 gtaggatttg ttcactgtat gtaaatttac accaatattt tcagccatac ttcttacaga
      541 tggaagtgat tcatttattt tcaattctcc tgaagctata gccttagtta tttcttcttt
      601 aatttgtaca taaatagatt tatcactatt aaaatctaaa tttaaaacca taaaaaacct
      661 ccattatgct ttataaatga aaacgattgt tatatacata gtataacata aaaaataata
      721 acaaacacaa aatataagtt tatattttgt aaaaattgta atttaaaaaa taacataatt
      781 tttattaaaa taatacagat actatttata gatagaaata aaaattagaa aggagaaaaa
      841 atatgttaac atatttaatg aaaagacaaa tgcataaaaa agatgatgga atgagtaaac
      901 caatgatgat tacaggagct gtaattacag gtgtaggagc atatgctgta tataaaatgg
      961 taaaaagcca taaatctaat tctcaaatgg tcaatacaaa ttattatgga aatagcgatt
     1021 atgatgatta taaatatgac gaatttgatt atgactgtga ttgtagagac acaaaacaag
     1081 attatgaata tgaagaatta aaaaaaaaag taaaagaatt taattcaaga agaataaatt
     1141 gtgaaaattg tccacatgtt tctcaagaag aaatgatgca atatgtaaat agtgttaaag
     1201 atgtaaagga agagattgat ttacatgaag atgctaaaaa agataatatt tacaaagaag
     1261 atgaatacaa aaaatatgaa gaagaataag taatattttg tataactgaa caaatagtaa
     1321 tgtcaaatta tttaatatct agttttaata tgtaagttgt aacttaactt gaaagaatca
     1381 gtatcattct ttagatagtt aagtaacaac ttacatttta tttttataaa ttttaatagt
     1441 tctttgtgac tattttgtaa ttttagaaat attttagtat ccagggtaat tgtgtataat
     1501 aaaacttgta tagatagata gtatgaaatt aagcagatag tttaaaatta aaatgaaaag
     1561 aaaggaaata gttatgttaa agttgttgat agttgaagat gatagtacta tatcttttgg
     1621 aataaagtat gctttagaac aagaaggatt tagtatagat atatcaaagg atttatctag
     1681 tggaaaagaa atgatttctt ctaatgaata tagcatgata ctgttggatg ttacattgcc
     1741 agatggaact ggttatgagc tttgtcaata tataagagga ttctctcagg ttcctataat
     1801 attcttgact gcttgtgatg aagaagtaaa tattgtaatg ggtctcgata taggtggaga
     1861 tgattatata acaaaacctt ttagaattag agaattaata tccagaataa aagctgtttt
     1921 aagaagaaaa ggtaatactt cagaagaaaa taagaaaata cttaaatttg gagatttaag
     1981 tatatataca ttagaagcta gagtatataa aaatgataaa gaaatatttc tgacatcagt
     2041 tgaatataaa cttcttttaa ttcttataca gaataaaaat actgttttaa gtagaactca
     2101 aatattggaa aaactttggg atgtaactta tgattttgta aacgacaata ctctaactgt
     2161 ttatataaaa aggcttagag aaaaaatagg tgatgattta tgtgaaccaa tctacataga
     2221 aactgtaagg gggattggtt ataaatggat aggaagtgaa aatagtgttt ctatataatc
     2281 cagaagtgaa gaagttttta agtaagtatg ttactttgat gtttattgtt atcataatat
     2341 ctattggatt tagcataatc aacgtgtcct taactaaaga gatggttgta agaaataatc
     2401 aggctataat aggaacttta tcaagcaagt atccaaactt ggaaagtcag atagtagaca
     2461 taataactca agggaagtct atggagaaca tagattatgg tcagaaaata ttaattaagt
     2521 ataattatga taaatctatt aggataaact ctgagcctat tatttctaaa ttagttttag
     2581 agactatcaa aataaatata atattagtat gtataatatt tattttgata tttgtgttgg
     2641 ttgttagata ttttaagtca atttacaatg atttatcaga tatgactaag tatgtttact
     2701 atagttcaga gggtaagcca tttgatatga aaaacaagaa tcaagaaggg cagataggtc
     2761 ttctaaaaac tgaactctta aagatgacaa caattcttaa tgaaaaggtt gaacttttaa
     2821 aaagagaaaa gatattttta aacaatacaa tttccgatat atcacatcaa ttaaaaactc
     2881 ctatgacttc tttaataatg ttgaatgatt tattatataa tgatgtacca tacgaagtaa
     2941 aaatcgattt tttaaataag ataaaaaatc aattaaatag aatggattgg ttgattaaaa
     3001 gcatgcttaa attatcaaag gtagaagcaa aagtgataaa ttttaaaaaa gataaggtaa
     3061 aatttagtga actcatacat agagcaatgc tatctatgaa aatacctatg gagattaaaa
     3121 atcaaaaact gactatagag ggaaatgata atgtatctta tattggtgat attgattggt
     3181 ccgtggaagc attagtgaat ataatcaaaa attgtgtaga acatactcct gaatttggaa
     3241 atataattat aacctataaa gaaaatccat tattttctga actaataata aaagatgagg
     3301 gtgaaggtat agataaaaaa gatataccac atgtatttaa acgattctat agaggaagaa
     3361 gtagttcaaa agaagatagt gtaggaatag gtcttgcaat gtcaaaatct ataatagaaa
     3421 gccaaaatgg cgatatatat gtaaacagcg aaaaaggtca gggtacagaa tttcatataa
     3481 tatttcataa aatgtatgat agtgactaat ctgtaatatt taattcactt tatagtaata
     3541 gccaaaacct aatatatgaa gtatagaata taaatattgg aggtagttat ggaaatttta
     3601 agagtagaaa atctaactaa aagttatggt aaaaatgaaa caaaagttga tgctataaaa
     3661 aatgtaagtt tatcagttga aaaaggaacg tttatagcaa taacaggtcc aagtggaagt
     3721 ggtaaaagta ccttattaca tttattagga ggagttgaca gaccaactag tggtaaggtt
     3781 tatataaatg atgttgatat atataattta aaaactaagg atttggcgat atttagaaga
     3841 agaaatatag gtcttatata tcaattttac aacttaattc cagtcttaaa tgtgaaggaa
     3901 aacatattgc ttccagcaga gcttgacaat agagatattg atagagaata ttttgatgat
     3961 ttaatgaaaa cattaggtct aattgataga gaaaagcacc ttccaaacca attatcagga
     4021 ggtcaacaac agagaacctc tataggacgt gcattaatta atagaccttc tataatatta
     4081 gcagatgagc caacaggtaa tttagatagt aaaaattcaa aggaaatatt agaattgtta
     4141 aaattgtcag taaaaaaata caaccagaca ctaataatga taactcatga caaaaatatg
     4201 gcacttcaag ctgatagaat tataagcata gaagatggaa tcataaaaag tgatgaggtg
     4261 atgtagatga atttatatac attactaacc attagatact taaaacaaaa taaaagaaga
     4321 accattgtaa ccataatcgg tataatactt tcaacagctt taatttgtgg tataggaaat
     4381 atatttgaaa gttttatgga ttatcaaatg agagaaacta taaagaatga tggaagtttc
     4441 catgttacat tttatgatgt aaatagaaaa aatgtggaat atgtaacgaa atcagctgaa
     4501 atagaaaaac atgcatttac caaacaactt ggatattcta aattagaaaa tagtgaaaat
     4561 gctatattaa gtataaagca atatgataaa aatgcaataa atggatataa agtttctata
     4621 aaagaaggta gatttccagc taaggaagga gaaattgttc taagtgaaag tattattaat
     4681 cttatagatg ataagttaaa aataggagat aagataactt taaaagtagg ggatatgttt
     4741 gactcaagca agaaaaagat tgatagtatg acatttcatg aaggtgatta tatagcaaat
     4801 gaaaaagata gaacttttaa agttgttggt ataattgaaa aacctgggtt tgaacgttat
     4861 aatggaattg caacagctat agcctacttt aatcctatga ataattacaa tgatacaatt
     4921 aatgtatcag tagcagtaag aaatcctaaa gatgtgtata agataagtaa taaaataagt
     4981 aaaaatatat attcaaataa agataaagaa gcagtttctg atatgataaa atacaatgaa
     5041 catttattga ggttacaagg tgctagtaag tattcaaata taaataactc tataaagtct
     5101 ataattatag cagtaactat tttagtaatc atatgtacaa ttgctacagt gtacaattcc
     5161 tttagtattt ctataaatga acgaaaaaaa cagtttggga tattaaattc tataggtgct
     5221 acatctagtc aaattaaaag attagttttt atagaaggta ttataattag tttaattggt
     5281 ataccaatag gactaatatc tggaacagta gctatagacc tattgtttaa aattataaat
     5341 aagtatttta ctgaatcggt tgttactaag atgagtttgc agatagtgta taatccaata
     5401 ataactattg ttagtataat aatagttttg cttacaatct ttatatcaat tctactacct
     5461 gcaatatcgg cttctaatat ttctcacctt aatgtgatta aaaatactgg agagtataaa
     5521 gtgggcaaaa tcaaaagctc aagacttatt aaaatgattt ttaaaactga aggagtactt
     5581 gcatataaaa atattaggag aaatagaaaa aaatttataa taactctttt ttctttaatg
     5641 gtaagtataa taatatttat atcttttagt ggctttacat tacttttact aagaggtgaa
     5701 gaaattagaa attctcaaag aaaatatgat ttgtatttaa ctgcaaagaa cacagctagg
     5761 tctgtagagg atactataag tgaactagaa gatattgatg ggataaaaaa ctttgaattg
     5821 gcaacaggac aatatgtgtc tataagagta agtgaaaata aaataaataa atccaaggaa
     5881 gatttaatca ggaaatatta tcaaaaatat aagattggag atagttatga atatgatttc
     5941 agtaataatg aattaatttt tccaggagat tttgcagtaa aaaacaaaat aaataactta
     6001 gtacagggct cttttaataa agagagagca attgaagaaa atggtgttat attagttaga
     6061 aaaagtgcat ttgaagaaaa tgggaagaaa ggtgtagtag aacttaccaa ctataaagta
     6121 ggagatacag taaattgtga atatcttgat gaaaatgcct taagtaaaaa agtaaaggtc
     6181 aagattcttg ctataactga cgaagaacgt ctaggtcttg gttatcaaaa tatggggtta
     6241 caatttataa cttatgatga agttgctaaa aatttaaatt taaaattaag taaaagcctt
     6301 atatttattg attcaggagg aagcattaag actaagaagg aaatagaagc tttggcaaat
     6361 aaaaataatt ttaactttta tgatgaaagt gcaagcaatg aaagtgaaaa acaagattta
     6421 aaggttatta aaatatttgt atatggtttt atagtagtga tatctttagt gagtgttaca
     6481 aatattctaa atacagtaag tacaagtata aatctaagaa aaagagaact tgcagtaata
     6541 caatctatag gggttactcc taaaggattt aggaaaatga tatatttaga aagttttata
     6601 tatggtatac tgtcattgtt gtttggaata ccaattagta ttggtataat tctaattatg
     6661 aataaactta tttcaggtgt aattgaattt tctccgatta taccgtggac agccatagtt
     6721 atctgtatag taagtgtttt tataataact tttatag
//
LOCUS       DAEQCW010000150         6623 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.151, whole genome shotgun sequence.
ACCESSION   DAEQCW010000150 DAEQCW010000000
VERSION     DAEQCW010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6623)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6623)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6623
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.151"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            188..1930
                     /locus_tag="KRO40_003311"
     CDS             188..1930
                     /locus_tag="KRO40_003311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M3"
                     /protein_id="HBH2094107.1"
                     /translation="MVKSKKKIFVFLILIAVFIIFASYIRNYTNDTKKDSVRGTIPFE
                     KMEYKRPNIQSICENINKCNDKLLTAKTAKEQLNLFNEVDKIYQDFYSTLTIAKIRNN
                     IDSSDEFYSKEYKYLMSKSVDVDMSYKDFQDRFVTSKFSKELEKELGNDTFNYLKNIG
                     KLNSKEVEGLLKKEQDLVVKYEDLLAKSTVSIDGIEVDFEEALSRPNLSPEEYVKIYS
                     DYLKKYNPIFGNIFLELIQTRTEIASKQGFKNYIDYAYMNLNKDYSQEEAKKFRQDVK
                     DYIVPLYREISSKPSDSSIYIKVYKNRSFRKFDKVLEDISPKLKESFDYMKKYDLYDY
                     SSGKNKSPGGYTTYINKYKAPFLFNTWDNSFLGVTSFAHEFGHFYNYYNSINLNNKMQ
                     PSIDVCEVHSTSLEILFYKYFDDFFGKQSEAIKKEHLSIVLNTIIDACLYDEFQEIIY
                     KNPYMSLNDINKLFFDLEEEYGVSNNILREKNAPFWILVSHNFQVPFYYLSYGLASDV
                     SLQIWQLSQEDYRKAVDVYMDFLNQNTDAGFKDVVEKVNLQLPFQNGNLEEISSTLYD
                     YFGIDNPLELKNAS"
     gene            complement(2094..2288)
                     /locus_tag="KRO40_003312"
     CDS             complement(2094..2288)
                     /locus_tag="KRO40_003312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094108.1"
                     /translation="MKIITIGSSLITVLLFLSTMVCGFWIKNNKVTDASSIKFHMNSA
                     IFTGIFLLISTILLIIYIKK"
     gene            complement(2285..2866)
                     /locus_tag="KRO40_003313"
     CDS             complement(2285..2866)
                     /locus_tag="KRO40_003313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBH2094109.1"
                     /translation="MKSNDKDARERIIEVTLNLLNEVDDIEEITVRKIAERANVGVGL
                     INYHFKTKDNLLSTAIGDVMSNIIAELYDDSVYTLRPIEDLKNLLKKLCDTGLHYEKV
                     LPFVLNQCITNGDMQAELDIVPMLRKIFGNKKDEMSLRIIALQIILPIQISALSTESF
                     QLYSGINIKNKYERDKFIDILIENIIGEDVDVR"
     gene            3034..3852
                     /locus_tag="KRO40_003314"
     CDS             3034..3852
                     /locus_tag="KRO40_003314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2094110.1"
                     /translation="MFKIGDFSKLSKISIRMLRHYDEIGLLTPSHTNKTNGYRYYSAD
                     QLSTTNRIHALKDMGFGLYSIKEILTEYNDKESLIKYLNIHHSQVKEQLEDTQKKLLK
                     IETTIKRIGGNDIMKNYDVTIKNFAPKYMMTLRRVIPTYQDEGMLWHQAFLETKDQNV
                     QIEPPKYSKTVFYDTGYKEDYVDVEVQVAVSGKYKDTEHVKFKTVPSVTAATAIVNGN
                     FNQVADACEAIGNWISDNNYDVDGPMFNIYHVSPGNDSNPDNWVTEVCFPVKKK"
     gene            4586..5407
                     /locus_tag="KRO40_003315"
     CDS             4586..5407
                     /locus_tag="KRO40_003315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002572585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallohydrolase"
                     /protein_id="HBH2094111.1"
                     /translation="MKLKIVGSGGMSIIPSSFCKCKICEEARQKGGRYERLGPSLYID
                     DIKMLIDTPEDIAVACNRQKISEVKHISISHHDPDHVKGIRIVEKIGCDFITGENNPI
                     GFYALPEVIEDINRTNLDCLKYYGDVINCISINETSHVKINNFDIDLINNNPDRNITF
                     YVIKENEKKVIYACCNPKPFTHSDMYFDADILIISLVSDDGILNDGTKLKDTPFKDEI
                     FTLDEIVEIKNYYRIKKIIVTHIDEMWGKSYGYYSELEKKLDNIYFAYDGMEIIV"
     gene            complement(5717..6496)
                     /locus_tag="KRO40_003316"
     CDS             complement(5717..6496)
                     /locus_tag="KRO40_003316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HBH2094112.1"
                     /translation="MSYKKIAIITGANSGFGKEFLKLLINEEEITEIWAVARNKARLN
                     QLVDEFGSKVKIFSKDLSKIEEVKEIGTFLSKENVCIKYLINNAGFAKFCSYNDLSID
                     ESINMIDLNISAVVALGLICIPYMQKGSHIMNISSQASFQPLPYQNIYSSTKAFIRNY
                     TRALNVELKSKGINAIAVCPGWMSTNLFKRGIVVAEKGTKNFPGIVSPDVVAKKALKD
                     AKKNKDISVYGINTKSSHLLAKLLPQKMMMKVWLMQQHIKE"
BASE COUNT         2480 a          901 c          836 g         2406 t
ORIGIN      
        1 tactattttg tacttaaaat ttatttatca ttttaccagt ataaatttca tatacttttt
       61 tgaagttaaa ttttttatat tatttataat cttatctata tctttatgtt aaattttctt
      121 aacatgcatt ttttatattt aatatagtaa aataattaat aactatatcc atgattggag
      181 gatttttatg gttaaatcca agaagaaaat atttgttttt ctaattttaa ttgcagtttt
      241 tattatattt gcatcataca taagaaatta tactaatgat acaaaaaaag attctgttag
      301 aggaactatt ccttttgaaa aaatggaata taagcgtcct aatatacagt caatttgcga
      361 aaacattaac aaatgtaacg acaaactttt aacagctaaa acagctaagg aacaattaaa
      421 tttatttaat gaagttgata aaatttatca ggatttttac agtacactta ctatagcaaa
      481 aattagaaat aacatagatt catcagacga attttactct aaggaatata agtatcttat
      541 gagtaaatca gtagatgttg acatgtcata caaagacttt caagatagat ttgtaacttc
      601 taaattctct aaagaattag aaaaagaact tggaaatgat acatttaatt atctaaagaa
      661 cattggaaaa cttaattcta aagaagttga aggtttgctt aaaaaagagc aagacctagt
      721 tgtaaaatat gaagacttat tagctaaatc tacagtatca atagatggta tagaggtaga
      781 ctttgaagaa gccttgtcaa gaccaaatct tagccctgaa gaatatgtga aaatttattc
      841 agattactta aaaaaataca atcctatatt tggtaacata ttcttagaac ttatacagac
      901 aagaactgaa atagcaagta agcaaggatt taagaattat atagattatg cctatatgaa
      961 cctaaacaaa gactattctc aagaagaagc taaaaaattt agacaagatg taaaagatta
     1021 catagttcca ttatatagag agatttcatc taaaccatct gattcttcta tttatattaa
     1081 agtatataaa aatcgctcat ttaggaagtt tgataaagta cttgaagata tatctccaaa
     1141 actaaaagag agcttcgact atatgaaaaa atatgacttg tacgattatt cttctggaaa
     1201 aaacaaatca cctggaggat atactactta tataaataaa tataaagcac ctttcttgtt
     1261 taatacatgg gacaattctt ttttaggtgt tactagtttt gctcatgagt ttggtcattt
     1321 ttataattac tacaacagta ttaacttaaa taataagatg caaccaagta tagatgtatg
     1381 tgaagttcat tcaacatctt tagaaattct attttataaa tattttgatg atttttttgg
     1441 taaacaatct gaagctataa aaaaagaaca cttatcgatt gttttaaata ctattattga
     1501 tgcttgtctt tatgatgaat ttcaagaaat tatatacaag aatccatata tgagtctaaa
     1561 tgatatcaat aaattgtttt ttgatttaga ggaagaatat ggagtttcca ataatatact
     1621 tagagaaaaa aatgctcctt tttggatact tgtatctcat aacttccaag ttccttttta
     1681 ttacttgagt tatggtcttg catctgatgt atcacttcag atatggcaat tatcacaaga
     1741 agattacaga aaagctgttg atgtatatat ggatttttta aatcaaaata ctgatgctgg
     1801 atttaaagat gtggtagaaa aggtaaattt acaattacct ttccaaaatg gaaatttaga
     1861 ggaaataagc tctactttat atgattattt tggtatagat aatccacttg aactaaaaaa
     1921 tgcttcttaa tttctaatac tttatactca ctcttaagat ttagtattag attgaaataa
     1981 gtgatatttt ttcacacaca attaatgttt aataaaatta tatggtaaag tatcagaaat
     2041 ttttaagact cttgtcttta taatttctga tactttattt attaataata ttattatttt
     2101 tttatatata taattaaaag gattgtggaa atcaataaaa atatccctgt aaaaatagca
     2161 ctattcatat ggaacttaat agaacttgca tctgttacct tattattctt aatccagaac
     2221 ccacaaacca tagttgaaag aaaaagtaaa acagtgataa gacttgaacc aatagttata
     2281 attttcatct tacatcaaca tcctctccaa taatattttc tattaaaata tcaatgaatt
     2341 tatctcgctc atatttattc tttatattta taccactgta taactgaaat gattctgtag
     2401 ataaagcaga aatctgtatt ggtaaaataa tttgcagggc aatgattctt agactcattt
     2461 catctttttt atttccaaaa attttacgaa gcatagggac aatatcaagt tctgcttgca
     2521 tatctccatt ggttatacat tgattcaata caaaaggaag cactttttca taatgtaatc
     2581 cagtatcaca caattttttt aataaatttt ttaaatcttc aataggtctt agagtatata
     2641 cactatcgtc atatagctct gctattatat ttgacatcac atctcctatg gcagtactca
     2701 acaaattatc ctttgtttta aaatgataat ttattaaacc aactccaaca tttgcacgct
     2761 cagcaatttt tctaactgta atctcctcaa tatcatctac ttcatttaaa agattcaatg
     2821 taacttcaat tatacgttct ctagcatctt tatcattact tttcataata gacctccaaa
     2881 acaattaaca ttttcagttc tgaacatgtt cagtataata tttttttcat catatgtcaa
     2941 tataatttaa ttataatttt agttgactct aacattatga tatggtttat attaatatta
     3001 agctaaaagt acctttataa aggagacaaa aacatgttta agataggcga tttttcaaag
     3061 ctaagtaaaa ttagtattcg tatgttacgt cattatgatg aaataggact tttaactcct
     3121 tctcatacga ataaaactaa tggatataga tactatagtg cagaccaact ttctactaca
     3181 aacagaatcc atgcactaaa agatatgggc tttggcttgt attctataaa agaaattttg
     3241 acagaatata acgataaaga aagtctcata aaatatctaa atatccacca ttctcaagta
     3301 aaagaacaat tagaagatac acagaaaaaa ctattaaaaa tagaaaccac tattaaaaga
     3361 attggaggaa atgatattat gaaaaattat gatgtaacta taaagaattt tgcaccaaaa
     3421 tatatgatga cacttagaag ggttatacca acttatcaag acgaaggaat gttatggcat
     3481 caagcatttt tagagacaaa agaccagaat gttcaaattg aacccccaaa gtattctaaa
     3541 acagtttttt atgatactgg atataaagaa gattatgtag atgttgaagt acaagttgct
     3601 gtatctggaa agtataaaga tactgaacat gttaaattta agactgttcc aagtgtgact
     3661 gctgcaactg caattgttaa tggaaatttc aatcaagttg cagacgcttg tgaggctatt
     3721 ggtaattgga tatcagataa taactatgat gtggatggtc ctatgtttaa tatttatcat
     3781 gtaagtcctg gcaacgatag taatcctgat aattgggtaa cagaggtatg cttcccagtt
     3841 aaaaagaagt aatttttata ttaattggat aatattttaa tttgttagac aaattacttt
     3901 tagtgttatg tataaatacc tacaatttga ttaggatatt atcttaattt gttaaacaaa
     3961 ttacttttag tgttatgtat aaatatctac aatttaatta ggatattatc ttaatttgtc
     4021 agataaatca cttgtgatgt tatgtttaaa tgactagaat ttgattggga tattatctta
     4081 atttgtcaga taaattactt ataagattac atacaaccct catactctag ttaaatattt
     4141 gaatcactaa tataaattag tttttaacaa aacaaagagt aaagtacaaa taattccttt
     4201 gtactctact ctttttaact ttctttgtac aataatacaa tgataaatat aaaaaattat
     4261 atattccatt ctatagaaat atgctcacca ataacatgta tgttgttaat caatatatta
     4321 tatcaaatta tatcaaaatt acataaacct tataggacaa tcatatctta ttacaagaaa
     4381 aatgtcttat ccatattgaa taagtcattc ggttcatata caaagtcaat ttcattgaga
     4441 aatatttaat atatgcttat aaaaatttca tactattctt tcatatttac atgtgatata
     4501 atttattaac tcataatttt gttaatcagt tgtgattgta gattatttat ataatctaat
     4561 atttttagaa ggtggtgtaa taactttgaa attaaaaatt gttggtagtg gcggtatgtc
     4621 aattattcca agttcatttt gcaaatgcaa aatatgtgaa gaagccagac aaaaaggcgg
     4681 aagatatgaa cgattaggac caagtttata tattgatgat ataaaaatgc tgatagacac
     4741 acctgaagac attgcagtag cttgtaacag acaaaaaata tcggaagtaa aacatatttc
     4801 aatttctcac catgacccag accatgttaa gggtattaga attgtcgaaa aaataggatg
     4861 tgactttatc acaggagaaa ataatccaat tggcttttat gcgcttcctg aagtaattga
     4921 agatataaac cgaacgaatc tcgattgtct taaatattat ggtgatgtta taaattgcat
     4981 ttctattaat gaaacttcgc atgtaaagat aaataatttt gatattgatt tgattaacaa
     5041 taacccagac aggaatataa ccttctatgt tatcaaagag aatgaaaaaa aagtcatata
     5101 tgcctgctgt aatcccaagc catttactca tagtgatatg tactttgatg ctgatatttt
     5161 aataataagt ctagtttctg atgatggtat attaaatgat ggtacaaaac ttaaagacac
     5221 accatttaaa gatgaaatat ttactttaga tgagattgtt gaaattaaaa actattatag
     5281 aattaaaaaa attattgtta cacatattga cgaaatgtgg ggaaaatcat atggttatta
     5341 cagtgaatta gaaaagaaac ttgataacat ttattttgca tatgatggta tggaaattat
     5401 agtctaaatc attaagtaat aagcataatg caaaataaga aaacttcaat ttaacagtat
     5461 agtcaaacta tgtgatatca acatatcgca gtttttacaa aatatcatag tatttatctt
     5521 tataaaattt caagtcctac atattttaat acttcaatat ctaaataaag taaaatcaaa
     5581 aatatatttt atatacatta tagacggctt atcgtcacta gataagccgt tttgtcacaa
     5641 ttattatttg ctcaacaaaa cttctcataa tatataacag attgaatctc caactgatac
     5701 ttaattacca aaactcttat tccttaatat gttgttgcat taaccaaacc ttcatcatca
     5761 ttttttgtgg caatagtttt gctaataaat gactggattt tgtatttata ccatacacag
     5821 aaatatcctt atttttcttt gcatccttca atgctttttt ggcaacaacg tctggagaca
     5881 ctatgcctgg gaaatttttt gtcccttttt cagctacaac tatacctctc ttaaatagat
     5941 ttgtactcat ccaacctgga catacagcaa ttgcatttat ccctttactc ttaagttcaa
     6001 catttaatgc tcttgtataa tttcttataa acgctttagt tgaactataa atattttgat
     6061 atggcaatgg ctggaatgat gcttgtgaag aaatattcat gatatggctt cccttttgca
     6121 tatatggaat acatataagt cccaatgcta caacagcact aatatttaaa tcaatcatat
     6181 taatagattc atctatactt aaatcattgt atgaacagaa ttttgcaaaa ccagcattgt
     6241 ttataaggta ttttatacat acattttctt tacttaaaaa tgtaccaatt tcttttactt
     6301 cttctatttt tgataaatct tttgaaaaaa tttttacctt acttccaaat tcatctacta
     6361 attgatttaa tctcgccttg tttcttgcaa ctgcccatat ttctgttatt tcttcttcat
     6421 ttattaataa ctttagaaac tctttaccaa aaccactatt agcacccgtt ataattgcaa
     6481 tcttcttata actcataatt attctccttt accataagtt tatacgctca aactgtaaac
     6541 ttatttttta caaataaaac accctctatt cagatgttat attcatatta tttgagatat
     6601 tatatttata tcattttcaa taa
//
LOCUS       DAEQCW010000151         6542 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.152, whole genome shotgun sequence.
ACCESSION   DAEQCW010000151 DAEQCW010000000
VERSION     DAEQCW010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6542)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6542)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6542
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.152"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..474
                     /locus_tag="KRO40_003317"
     CDS             <1..474
                     /locus_tag="KRO40_003317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094113.1"
                     /translation="TFNISNKFMDNLNKEKNANPKEIGLLSKTKLDYMVKNNKLNLIV
                     TDMSNSITNLVYDINSNEIKLEDYEILDLKVDYNEASSGVRKVKLLDDKIYSISGIKN
                     SISGELKGFKGIVDVVGTKPVKFQVFDMKLKKNIYEAELINGDISLQEKLFFVAN"
     gene            840..2021
                     /locus_tag="KRO40_003318"
     CDS             840..2021
                     /locus_tag="KRO40_003318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBH2094114.1"
                     /translation="MNKKYIKAGNLIDGTGNSIMQNKGIIIDGDTIVEIEDIRDDLNG
                     YDVYDYLDKTVMPGIMNCHVHLTMEPVGNPKIYYDNVSDVELVVNTIKQLDAYLDSGV
                     TYIRSLGCPKYVDVQLKNLIDKGSIDGPGIVTSGPVICMTGGHGYYFGIESDGVDECR
                     KSARTVLKNGVDCVKIMATGGVTTDGVEPGSPQLTLEEMKAAVDEAIKAGKITATHAQ
                     GRTGIKNAVLAGITSIEHGVYLDDEIIDLMLERGTYLVPTVAAPYFILNAGKESGITE
                     ATLRKCEIVAIPHKESFLKAYKKGIKIAVGSDAGTSYNEHGKTYYEMKLMSDYGMDNM
                     DIIVAATKTASELLRIDKNYGTLEKGKKADVIVVNGNPVENIDVLADVLAVFKLGKKV
                     R"
     gene            complement(2163..3080)
                     /locus_tag="KRO40_003319"
     CDS             complement(2163..3080)
                     /locus_tag="KRO40_003319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094115.1"
                     /translation="MENNKCREDFRFTQEYEEDYPNTNERYYENYQVADRYYNYPNKY
                     KEPKIKQCCCKKSMREALELLRYDALRPFVNFNQFAFISDFFIVGANLVGIDLSAPPK
                     DNLSGLDGTFERFSACNCDLIDIAGRVSYPIPVPLTLEGLINTIGTIPGVAELIALID
                     AVIPPTIDLGAILDAILAAIIDFILAASTPLANVDLASLCNLKAVAFDITPADYEDFI
                     ASLGYYLDKKHYKECNCNCDCDDCCCNKGILDNLYMSNINNQVTVVAGSLVLTGVEVL
                     GKKNDVIVLGNSNDSRIYFVCVDSIDYIA"
     gene            3333..4127
                     /locus_tag="KRO40_003320"
     CDS             3333..4127
                     /locus_tag="KRO40_003320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094116.1"
                     /translation="MIEVDKLCKSFTRVVKDDKNKSSIRKLKKVKTKKEEFFAVNNVS
                     FKVMEGEIVGILGPNGAGKTTLLRMLGGILTPTSGSINISGYDYSIDRNSAKKEIGYL
                     SGNTKLYGRLSPRELLTTFASLYEMSKEDIEESIENIVKIMDMSEFIDNRIENLSTGQ
                     TQRTSIARCLIHSPKVYIFDEPTLGLDVLSSASIIDFMKNEKLRGKTVLYSTHYMEEA
                     ETLCDKIFMIHNGKIIASGTPQSLKEESGVNNLRDVFIKLARKEDI"
     gene            4128..6188
                     /locus_tag="KRO40_003321"
     CDS             4128..6188
                     /locus_tag="KRO40_003321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBH2094117.1"
                     /translation="MRSKIVKYIFKKEMLDILRDKKTLFMMIVVPLLLYPLLMLLMIQ
                     VMNMSASSMNSKDINIAFNNKPNKVLVSMIEDDNLEKDTKNTSNDKGKIRVLDVDNYK
                     KSLEENKIDAYIKMEEKKSSINYQIYINSSQENSSNALKRIETVLDKYKRFTIEKTLS
                     EKGLDVQATLEPITYSTVDVAKTEEVAGYFLGQILPFILIIGVLLGSIYPAIDVMAGE
                     KERGTLETLFTLPISNLELVMGKYMAVSLSAIVTAILNILSMGLTMAFILVSGGISSQ
                     FGFGNFNYGDLVLPIITTLICICLFSMVVSAISMCVCSLAKSFKDAQNYITPLMLIIM
                     IPSYVSMIPNIVLDRVTAVIPVVNISLLIKSVLSFKSDLNLIALVLASNVAFVILAII
                     LLSKMFNSEEILFGNSKSFSFLEKRSNIKKGSIPTVSDGVILYAVGLVLLIYVGSLVQ
                     IKFGMAGIIMTQFMIISLPLLFAYYIKADFKEVFSLKVPKLKHVFGSIVLWIGGYILI
                     MIITQLILFLFPQNMEVAESLNKALFIKDSVLLNLLAIALLPALCEEMFFRGFIFSSF
                     SKSKDKNKSIKLAIICSGVLFGIMHMDFIRIIPTSILGIIFAYSVYKSGSIFVSMLLH
                     FLNNSVAVVLNHYTTGNITNLYKFVEVDFSNLNVLKFALILLISLILIMLGLRVLDRK
                     SLRN"
BASE COUNT         2538 a          695 c         1055 g         2254 t
ORIGIN      
        1 acttttaata taagtaataa atttatggat aatctaaaca aagaaaagaa tgcaaatcca
       61 aaggagattg gcttattaag taaaactaag ctagattata tggtaaaaaa taataaattg
      121 aatcttatag ttacggatat gagtaattcc ataactaatc ttgtttatga tattaattct
      181 aatgagatta aattagaaga ttatgagata cttgatttaa aagtagatta taatgaagca
      241 tcatctggag ttaggaaagt taagctactg gatgataaga tatattctat ttcaggtatt
      301 aagaacagta tatcaggaga attaaaagga tttaaaggga ttgttgatgt agtcggaact
      361 aagccagtaa aatttcaagt atttgatatg aaacttaaaa agaatattta tgaagctgag
      421 ctaataaatg gagatataag tttacaagaa aagttatttt ttgttgcaaa ttaagtgtta
      481 gaattaattt tagaacttta aacttttata tgtatcacag ataagtataa gtaagggagt
      541 gtctcaaaat aaacttttta gctcatgaga cacttttttt atatgaaatc aaatatattt
      601 tcattgttta gatttatttt gataatgaaa aaaagattat ctttatttta agaaagacat
      661 ttatttataa ttatatacaa aaatattttt taatgttttt gtgtataatt ataacaattt
      721 aatttatatt aatgcactta aatttgaaat agaatgctta tagtggtaaa attaattatt
      781 agaatattag aaataataaa taaataatac attgtactta aaagggggag aaatttaaga
      841 tgaacaaaaa atatattaaa gcagggaatt taattgatgg aaccggaaat agtattatgc
      901 aaaataaggg tataattatt gatggagata ctatagttga aattgaagat ataagagatg
      961 atttaaatgg atatgatgtg tacgattact tagataaaac tgttatgcca ggcattatga
     1021 attgtcatgt tcacttgaca atggagccag ttggaaatcc aaagatatat tatgataatg
     1081 tatcagatgt agagcttgta gtaaatacga taaaacaact tgatgcttat ttggattcag
     1141 gagtaacata tattagaagc ttaggttgtc ccaaatatgt ggatgtacaa cttaaaaatc
     1201 ttatagacaa agggtctata gatggtcctg gtatagttac ttcaggtcca gttatatgta
     1261 tgacaggagg gcatggatat tattttggta ttgaaagtga tggagtagat gaatgtagaa
     1321 aatcagccag aacagtttta aaaaatggag tagattgtgt aaagataatg gcaactggag
     1381 gtgtaacaac tgatggagtt gagccagggt caccacaatt aactttggag gaaatgaagg
     1441 ctgctgtaga tgaagctata aaagcaggta aaataactgc cacacatgca caaggaagaa
     1501 ctggtataaa aaatgcagtg cttgcaggaa ttacttctat agaacatggt gtttatttag
     1561 atgatgaaat aattgatttg atgcttgaaa gaggaactta cttagttcca actgtggctg
     1621 caccatattt tattctaaat gcaggaaaag aaagtggaat aactgaagct actcttagaa
     1681 agtgtgagat tgttgccatt ccacataaag agtcattcct aaaagcatat aaaaaaggaa
     1741 ttaaaattgc agttggttct gatgcaggaa cttcttataa tgaacatgga aaaacatatt
     1801 atgaaatgaa actaatgtca gattatggta tggataatat ggatataata gttgctgcta
     1861 caaaaacagc atctgaactt ttaagaattg ataaaaatta tggaactcta gaaaaaggaa
     1921 agaaagcaga tgttatagtt gtaaatggaa atccagtaga gaatatagac gtacttgcag
     1981 atgtgttagc agtatttaaa cttggtaaaa aagttagata aatagtataa aaataaaaaa
     2041 gagtgtctaa agaaattttt aaataattat agacactctt ttttattagt aataattaaa
     2101 tcttttatac tttagaaaat agattctatt ttatatttag atataactct ttaaaatcat
     2161 tcttatgcaa tataatctat agaatctaca catacaaagt atattcttga atcattagaa
     2221 tttccaagta ctataacatc atttttctta cctagaactt caacaccagt tagaaccaaa
     2281 ctaccagcta ctacagtaac ttgattattt atatttgaca tataaagatt atctaggata
     2341 cctttattac aacagcaatc atcacaatcg cagttgcaat tacattcttt gtaatgtttt
     2401 ttatcaagat agtaacctaa agatgctatg aaatcttcat aatctgcagg tgtaatatca
     2461 aatgcaacag ctttaagatt acacaatgat gctaaatcta cgtttgctaa tggagtagat
     2521 gcagcaagta taaaatcaat tatagcagca agtattgcat ctaatatagc cccaaggtct
     2581 atcgtaggag gaataactgc atcaataagt gcaattaatt cagctactcc tggtatagtt
     2641 cctatagtat taattaatcc ctcaagagtt aaagggactg gaataggata agatactcta
     2701 ccagctatat ctattaaatc acagttacaa gcagaaaatc tttcaaaagt accatcaagt
     2761 ccagataaat tatcttttgg aggagctgaa agatctatac ctaccaaatt agcacctact
     2821 ataaagaaat ctgagataaa agcaaattga ttaaagttta caaaaggtct tagagcatca
     2881 tatcttagaa gttctaatgc ttctctcata ctttttttac aacaacattg ttttatttta
     2941 ggttctttat atttatttgg ataattatag tatctatcag ctacttgata attttcatag
     3001 tatctttcat ttgtatttgg ataatcttcc tcatattctt gtgtaaatct aaagtcctct
     3061 ctacatttat tattttccac taaatacact ccttttatat tttaatttaa atgtatagat
     3121 aattaagctt atctatatag taatattata tttataatgt aaaaaaatgt tacaaaagat
     3181 attataaacg aataaaaaat aataatttgc cagataaact tgtaaatttt tatgaataat
     3241 ccattctaaa acaaaaaact gtgtataaaa aaggtttata tgttatattt atataaatat
     3301 aacatatgaa cgagaaagga gtggtttgat aaatgattga ggtagataaa ttgtgtaagt
     3361 cttttacaag ggttgtaaaa gatgataaga ataaaagttc aataagaaag ctaaagaaag
     3421 taaaaactaa aaaagaagaa ttttttgctg taaataatgt ttcatttaaa gttatggaag
     3481 gtgaaattgt tggaatatta ggtccaaatg gtgcaggaaa gactacatta cttagaatgt
     3541 taggtggcat attaacacca acatcaggaa gtataaatat ttctggatat gattattcaa
     3601 tagatagaaa ttcagcaaaa aaagaaatag gttatctctc tggaaataca aaactatatg
     3661 gaaggctttc tccgagagaa cttctaacaa cttttgcaag tctatatgag atgtcaaaag
     3721 aagatataga agaatcaatt gaaaatattg taaaaataat ggatatgagt gaatttatag
     3781 ataatagaat tgaaaatcta tcaactggtc agactcaaag aacatctata gctcgttgtt
     3841 taatacattc tccaaaagta tatatttttg atgagccaac actaggtctg gatgttttaa
     3901 gtagtgcatc tattatagat tttatgaaga atgaaaaact aaggggaaaa actgttcttt
     3961 actcaactca ttatatggaa gaagcagaaa ctttatgtga caagattttt atgattcaca
     4021 atgggaaaat aattgcatca ggaacaccac agagtttaaa agaggaatct ggagtaaata
     4081 atttgagaga tgtattcata aaacttgcca gaaaggagga catttaaatg agaagtaaga
     4141 ttgtaaaata catatttaaa aaagaaatgt tagacatatt gagagataaa aagactttat
     4201 ttatgatgat tgttgtgcca cttcttttat atcctttact tatgttatta atgattcaag
     4261 taatgaatat gtctgcaagt agtatgaata gtaaggacat taatatagct tttaataata
     4321 aacctaataa ggttttagta tccatgattg aagatgataa tttagaaaaa gatactaaaa
     4381 atacttcaaa tgataaaggc aaaataagag tgttagatgt agataactat aaaaagtcat
     4441 tagaagaaaa taaaattgat gcttatataa agatggaaga aaaaaaatca tctataaatt
     4501 atcaaatata tataaattct tctcaagaaa attcttctaa tgcactaaaa agaattgaaa
     4561 ctgttttgga taaatataaa agatttacca tagaaaaaac tttatctgaa aaaggattag
     4621 atgtacaagc tactttagaa ccaataacat atagcactgt agatgttgca aagacggaag
     4681 aagtggcagg atacttttta ggtcagatac ttccatttat attaataata ggagttttac
     4741 taggttcaat atatccagca atagatgtta tggctggaga aaaggaaaga ggtacattag
     4801 aaacattatt tacactgcca atatcaaact tagaactggt tatgggaaaa tatatggcag
     4861 tttctcttag tgcaatagta acagcaattt taaacatttt atctatggga ctgactatgg
     4921 catttatttt agttagtgga ggtattagta gccaatttgg ctttggaaac tttaattatg
     4981 gagacttagt cttaccaatt ataactactt taatttgcat atgtcttttt tcaatggtag
     5041 tttcagcaat aagtatgtgt gtatgttcat tagcaaaaag ttttaaagat gctcaaaact
     5101 acataacacc tcttatgtta attattatga taccatcata tgtttctatg ataccaaata
     5161 tagtattaga tagagtgaca gctgtaatac ctgtagtaaa tatatcttta cttataaaaa
     5221 gtgtattatc ttttaaaagc gatttaaatt taatagcctt agttttagca tcaaatgtag
     5281 cctttgttat attggcaatc atactactgt ctaagatgtt caattctgag gaaatacttt
     5341 ttggtaatag taagagtttc tctttcttag agaaaagaag taatataaaa aaagggtcta
     5401 taccaactgt aagtgatggt gttattttat atgcagtagg attagttcta ttgatttatg
     5461 ttggttcttt agttcaaatt aaatttggta tggcaggtat tataatgaca caattcatga
     5521 taatttcttt accgttatta tttgcatact atattaaagc tgattttaaa gaggtattta
     5581 gcttgaaagt tcccaaatta aagcatgtgt ttgggagcat tgttctttgg attggtggat
     5641 acatacttat tatgattata acacagctaa ttttattctt atttcctcaa aatatggaag
     5701 ttgctgaaag tttaaataag gctcttttta tcaaagatag tgttttactg aatttactag
     5761 caatagcttt attaccagct ttatgtgaag aaatgttttt taggggattt atattttctt
     5821 catttagtaa atcaaaagat aaaaataagt ctatcaagct agctataata tgcagtgggg
     5881 tactatttgg tattatgcat atggatttta ttagaataat tccaacatca atattaggta
     5941 ttatatttgc atatagtgtg tataaatctg gttcaatatt tgtatcaatg ttattgcatt
     6001 ttttaaataa tagtgtagca gttgtgttaa atcattatac aactggaaat ataaccaact
     6061 tatataaatt tgttgaagtt gatttttcga acttaaatgt acttaaattt gccttaattc
     6121 ttctaataag tcttatatta attatgttag gattaagagt tttagataga aagtctttaa
     6181 gaaattaagt ataaagttat tatatagatt aaaatattaa taagcactaa agtatatgga
     6241 tatatcttgt atataaaaat actttagtgc tattttatat attttaatta tatgaattat
     6301 ttatcgtttc atttatgtaa tgaaaatgtt atataaatga aacaataaat aatttttatt
     6361 ttagaaattt atatttaaat aatcaagttg aaagtgagat actaaaaaaa ttaatttagg
     6421 aattatttga tttattcatt tataaaaatt aattactgat ttgtcgaaac cattgtaata
     6481 agaaaaaaat gaaaaaataa agtgtgaata tgttgcaaat actgtatttt gataaaaagt
     6541 ag
//
LOCUS       DAEQCW010000152         6469 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.153, whole genome shotgun sequence.
ACCESSION   DAEQCW010000152 DAEQCW010000000
VERSION     DAEQCW010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6469)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6469)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6469
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.153"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            154..2655
                     /locus_tag="KRO40_003322"
     CDS             154..2655
                     /locus_tag="KRO40_003322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="HBH2094118.1"
                     /translation="MSSNKVVESYKITGMTCAACAKAVERVTKKMDGVYDQSVNIATE
                     KLKIEYDNSKVNFDDIKQVVEKAGYGIIKEESNKKIDMKIDGMTCAACAKAVERVVKK
                     LDGVESISVNIATDKANIDYDPSKVKLSQIKAAIEKAGYKPIEEVKNKVDVDEDKLRK
                     EREMKSLFVKFIVAIVFAVPLFYIAMGPMIIKPIGPWPLPEIINPMTNTFNYALIQLI
                     LVIPVMIAGYKFYINGFKSLFSLSPNMDSLVAIGTLAAFLYSLYTTLQIANGQIQGMH
                     HHQLYYESAGIIIALILLGKYLESKSKGKTSEAIKKLMGLQPKTAIVLVDGKEVETPI
                     EEVEIGDILLVKPGTKIPVDGVVIEGYTSVDESMLTGESIPVEKNVGSKVTGASINKN
                     GVIKFKAEKIGGDTALAQIIKLVEDAQGTKAPIAKLADTVSGYFVPIVIAIAVVASLL
                     WFLIGGKDIVFVLTIFISVLVIACPCALGLATPTAIMVGTGKGAENGILIKGGEALES
                     AHKVNTVIFDKTGTITEGKPKVTDIVLNNNVKEEYLIKIASSAEKGSEHPLGEAIVKY
                     GEEKNIKFEKVDNFKAIPGAGIQVTINDESILLGNRKLMNDNNIKLGDLEEKSNILAS
                     QGKTPMYIAVDGNLSGIIAVADVVKESSKKAIEILHDMGIKVAMVTGDNAKTANAIAN
                     QVGIDMVLAEVLPEDKSKEVEKLQNQGKFVAMVGDGINDAPALAKADIGIAIGSGTDV
                     AIESADIVLMKSDLIDVPTAIKLSHETIKNIKQNLFWAFGYNTIGIPVAAGILYVFGG
                     PLLNPMIAAAAMSLSSVSVVSNALRLKNFKAYKRD"
     gene            2815..3483
                     /locus_tag="KRO40_003323"
     CDS             2815..3483
                     /locus_tag="KRO40_003323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094119.1"
                     /translation="MNSSILVIEDDSNIQELISEFLSAEGYQVDTANDGLEGIQKFKQ
                     GSYDLVILDIMMPNLDGYGVCKMIRKSSSVPIIFLTALNDEGDQLKGFDLECDDYITK
                     PFSFNLLIKRVEAILRRSNKTINDKFIVFEKLKLDLNTYIAEIDGEPIELTLKEFNIL
                     KALIEKYPQVITREGLLDSIWGYDYYGDTRIVDAHIKNIRKKISLPYIKTVKGIGYTL
                     EKDI"
     gene            3467..4744
                     /locus_tag="KRO40_003324"
     CDS             3467..4744
                     /locus_tag="KRO40_003324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HBH2094120.1"
                     /translation="MRRIFDKWEKLSIKYKLFSITTSLLIALALIIYLILYFLLPSYY
                     HEYKIESLQESLKSLVDSSIHFDTYTLEERLYYMAKDQNLAILLKDNQGKIVYGKNEV
                     VILRYSKYMINSLEDEYRTSIPIYTKDAKDGPYTLELVMPLQPIDEANEVIRKLMPYI
                     ISIAILIAIIGAYIYSIVITKPLINIIESEREQEYRRKDFVATISHELKTPITIISGQ
                     IEGMIYSVGKYKDRDTYLKKSYECTQELKDLVNEMIEVSKSEILEKDLKLVSINISEL
                     LNRLVKRQVFLIEEKHMKTILKIEENLEIKADQERITKAINNIINNAIKYSPEESELI
                     IRLYDKNKRISKKTSNQRVVLEIENTGVTIEKRYLEEIFNPFYRIEKSRSRKTGGSGL
                     GLYIVSQIFKSHGFDYSIKNKENSVVFTVEFKN"
     gene            5145..5366
                     /locus_tag="KRO40_003325"
     CDS             5145..5366
                     /locus_tag="KRO40_003325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094121.1"
                     /translation="MDRLKRDMKNMKEDLKEGVKKTAYVMKNTAEDLKDDAQGAMVNL
                     EMKKDEMMERYEQKKFSKELEKQMKNEMK"
     gene            complement(5655..6419)
                     /locus_tag="KRO40_003326"
     CDS             complement(5655..6419)
                     /locus_tag="KRO40_003326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBH2094122.1"
                     /translation="MFAEERIQAILNILKKEGRVTVKELSSKFNVTEDCIRKDLKNIE
                     KISSIRRIYGGAVLARETLENQDTKDRKEINIPTKKIIAEKAFNLIEDRETIFLDIST
                     INILLAKLLAESNKKVTLVTNMLDILNVVTSKPNNLNIISTGGLLNLSLDGFVGTPTI
                     EFISKYKFDKTFMGSCGVDVFNSSLTTFEIEDGLTKKAIINSSKKVFIVMEDKKFKFD
                     GNFKFAHLEDISSIITEKTPTPDIVDILSEFNVNVL"
BASE COUNT         2659 a          692 c         1072 g         2046 t
ORIGIN      
        1 acatttattt attaaaaaaa tattgattta atatacctat agggggtata ataaaaatat
       61 agatttctaa ataagtaatt tatcaatatt acatatcaaa ataaaacgtt acaaattagc
      121 tgaaaatata ttgaaagaaa ggaagatttt attatgagtt caaataaagt ggtagaaagt
      181 tataaaatta caggtatgac atgtgcagct tgtgcaaagg cagtagagag agtaactaag
      241 aagatggatg gagtatatga ccaaagtgta aatatagcta ctgaaaaact taaaatagaa
      301 tatgataatt ctaaggttaa ttttgatgat ataaagcagg ttgtagaaaa agcaggatat
      361 ggaattataa aggaagaaag taataaaaaa attgatatga aaattgatgg aatgacatgt
      421 gcagcttgtg caaaagctgt agagagagtg gtaaaaaaat tggatggagt agaaagtatt
      481 agtgtgaata ttgcaacaga taaagctaat atagactatg acccatcaaa agtaaaatta
      541 tctcaaataa aagcagctat tgaaaaagct ggatataaac caatagaaga ggtaaaaaat
      601 aaggttgatg tggatgaaga taaattgaga aaagaaagag aaatgaagtc tttatttgtt
      661 aaatttatag ttgcaatagt atttgcagta cctctgtttt atatagcaat gggacctatg
      721 ataataaagc ctatagggcc atggcctttg ccagaaatta taaatcctat gacaaatact
      781 tttaattatg cattaattca gttaatttta gtaataccag taatgatagc tggttataaa
      841 ttttatataa atgggtttaa atcacttttt tctttaagcc ctaatatgga ttctttagtt
      901 gcaataggaa cattagccgc atttttatat agtctatata cgacactaca aatagccaat
      961 ggacaaattc aaggtatgca ccatcatcag ttgtattatg aaagtgcagg aataataata
     1021 gcacttatct tacttggtaa atatttagaa tcaaaatcaa aaggaaaaac atcagaagca
     1081 attaaaaagc ttatggggct acaacctaaa actgcaatag tgttagttga tggtaaagaa
     1141 gttgaaactc ctatagaaga agtagagata ggagatatac tattagtaaa accaggaact
     1201 aaaatacctg tggatggagt tgtaatagaa ggatatacat cagttgatga atcaatgctt
     1261 acaggtgaaa gtataccagt agaaaagaat gttggaagta aggtgacagg agctagtatt
     1321 aataaaaatg gtgttattaa gtttaaggct gaaaaaattg gtggagatac tgctcttgcc
     1381 caaataataa agttagttga agatgcacaa ggtacaaaag cacctattgc taaacttgcc
     1441 gatactgtat ctggatattt tgtaccaata gtaattgcaa tagctgtagt tgcatcatta
     1501 ttgtggtttt taataggagg aaaagatata gtatttgtac ttactatatt tatatcagta
     1561 cttgtaattg cttgtccttg tgcattagga ttagcaacac caactgctat aatggttggg
     1621 actggaaagg gcgcagaaaa tggaatcttg ataaaaggtg gagaggcatt agaatctgca
     1681 cataaagtaa atacagtgat atttgataaa acaggtacta taacagaagg aaagccaaaa
     1741 gtaacagata tagtattaaa taataatgta aaagaagaat atcttatcaa gattgcttca
     1801 agtgcagaaa aaggttcaga acatcctctt ggagaagcaa tagttaagta tggagaagag
     1861 aagaatataa aatttgaaaa agttgataat tttaaagcca taccaggtgc tggtatacaa
     1921 gttactatta atgatgaaag tatattactt ggaaatagaa agcttatgaa tgacaataat
     1981 ataaagcttg gggatttaga agaaaaatca aatatattgg caagccaagg taaaacacct
     2041 atgtatatag ctgtagatgg aaatttatca ggtataatag cagttgcaga tgtagtcaaa
     2101 gaaagtagta aaaaagcaat agaaatactt catgatatgg gaataaaagt tgcaatggta
     2161 actggagata atgcgaaaac tgcaaatgct atagcaaatc aagtcggtat agatatggtt
     2221 ttggcagagg ttttaccaga agataagtca aaagaagttg aaaaactaca aaatcaagga
     2281 aagtttgttg caatggtagg ggatggaata aatgatgccc cagctcttgc aaaagcagat
     2341 atagggatag caataggaag tggaacggat gtagccattg aatctgcgga tatagtactt
     2401 atgaagagtg atttaattga tgttccaaca gcaattaaac ttagtcatga aactataaaa
     2461 aatataaaac aaaacctatt ttgggcattt ggatataata caattggtat acctgtagca
     2521 gcaggaatat tatatgtatt tggaggacct ttattaaacc caatgattgc agcagcagca
     2581 atgagcttaa gttcagtttc agtcgtatca aatgcactta gacttaaaaa cttcaaggca
     2641 tataagagag attagattaa taaattaaat aaaatgtatc caaaagagct atctttaaat
     2701 taaaaggatt aatttacaaa ttaagatagc tcttttttca tgtaaaattc acaacaataa
     2761 gataaaatat aagtaatata cgaaatttta aataaaatag aaaggattga tagaatgaat
     2821 tcgtcaatac ttgtaattga agatgattca aatatacaag agttaatatc agaattttta
     2881 agtgcagaag gttatcaagt tgatacagca aatgatgggt tggaaggtat acaaaagttt
     2941 aagcaaggaa gttatgattt agtaatatta gatataatga tgccaaactt agatggttat
     3001 ggagtttgta aaatgataag aaagtcatca agcgttccaa ttatattttt aactgcttta
     3061 aatgatgaag gagaccaact taaagggttt gacttagaat gtgatgatta tataacaaaa
     3121 ccattttcat ttaatcttct tataaaaaga gtagaagcaa ttttaaggcg aagtaacaag
     3181 actataaatg acaaatttat agtttttgaa aaattaaaat tagatttaaa cacatatatt
     3241 gcagagatag atggagaacc tatagaactt acactaaaag agtttaatat attaaaagct
     3301 ttgatagaaa agtatccaca agttataact agggaaggtc ttttggatag tatatggggt
     3361 tatgactatt atggagatac taggattgtt gatgcacata taaaaaatat aagaaaaaaa
     3421 atatcattac catatattaa aactgtaaaa ggaataggat atacacttga gaaggatatt
     3481 tgataagtgg gaaaagttaa gtataaagta taagttattt tcaataacga catcattatt
     3541 aatagcatta gctttaataa tatatctaat tttatatttt ttattgccat catattatca
     3601 tgagtataaa attgagtctc ttcaagaaag tttgaaatct ttagtagata gttcaattca
     3661 tttcgataca tatactttag aagaaagact ttattatatg gctaaagacc aaaatttggc
     3721 tattttatta aaagataacc aaggtaaaat tgtatatggt aagaatgaag tagttatttt
     3781 aagatatagt aagtacatga ttaatagtct tgaggatgag tatagaactt ctatacctat
     3841 atatactaaa gatgcaaaag atggtccata tactttagaa ctcgttatgc cattacaacc
     3901 aattgacgaa gcaaacgaag ttataagaaa actaatgcca tacatcatat caatagcaat
     3961 attgatagcg attattggag catatatata ttcaattgta ataacaaagc ctcttataaa
     4021 cataatagag agtgagagag aacaggaata tagaaggaag gattttgttg ctacaatatc
     4081 acatgaacta aaaactccaa taaccataat aagtggtcaa attgaaggta tgatttatag
     4141 tgtaggtaag tataaggata gggatactta tctgaaaaaa tcgtatgagt gtacacaaga
     4201 attaaaagat ttagtaaatg aaatgataga ggtttcaaaa tcagaaatac ttgaaaaaga
     4261 tttgaaattg gtatcaataa atataagtga attattaaat agacttgtaa agagacaagt
     4321 atttttaata gaagaaaaac atatgaaaac tattttaaaa atagaagaaa atttggaaat
     4381 taaagcagac caagagagaa taactaaggc aatcaataat ataataaata atgccataaa
     4441 atattctcct gaagaatcag agcttataat tagactctat gataaaaata aacgaataag
     4501 taaaaagact tctaatcaaa gagtggtttt agaaattgaa aatactggtg taactatcga
     4561 gaaacgttat ttagaagaaa tatttaatcc attttataga atagaaaaat ctcgttcgag
     4621 aaaaactgga ggaagtggac ttggacttta tatagtcagc caaattttta aaagtcatgg
     4681 gtttgattat agcataaaaa acaaagaaaa ctctgtagta ttcacagtag aatttaaaaa
     4741 ttaattactt attataaaga atatataact ttcaataata gttcatttta aaatcacaaa
     4801 aaattcataa tgaaactgta ttatataaat ataaataagc ttaaaaccat aaaatacacc
     4861 aactataatg atgagatttc cttacatcct ccatataagt catcattata gtaacccaac
     4921 aattaagtta ctatgaattt aaaaaataac accgagcata taatctatgc ttagtgttat
     4981 ttttattttg aaataaaaaa tatttaattt attgaaatgt atagatttag atagtttaaa
     5041 ctatatttaa gacttaaaaa ttataattga tattacaaat aaatatatgt actttgggaa
     5101 aaataaatat aggaagtatt atatttacag aggaggtagt tttgatggat agattaaaaa
     5161 gagatatgaa aaatatgaaa gaagatttaa aagaaggtgt taaaaagaca gcttatgtta
     5221 tgaaaaatac agctgaagat ttgaaagatg atgcacaagg tgctatggta aacttagaaa
     5281 tgaaaaaaga tgagatgatg gaaagatatg aacaaaagaa attttctaaa gaattagaga
     5341 agcaaatgaa gaatgaaatg aaataagctt ttatttatga ataacaaatt attgtattca
     5401 tataaaaagt agccagtaat attaaatagt ttatttaagg aaatagactt tctaaaaata
     5461 actgtattag atttagaaag tctatttcaa attagtttta taaatagaca taaggataaa
     5521 gtagatgtta tagaactaga ttttaaaaaa tagatactaa ggataaaata aatattatag
     5581 aaatatgttt ttaagaatat ttatcaaata aaaatttata tttataagaa atcctataaa
     5641 acatataatt aaacttataa aacatttaca ttaaattctg ataaaatatc tactatatca
     5701 ggagtaggcg ttttttctgt aattatagaa ctaatatctt ctaaatgagc aaacttgaaa
     5761 tttccatcaa atttaaactt tttatcttcc ataactataa atactttttt acttgaattt
     5821 attatagcct tcttcgtaag accatcttca atttcaaaag ttgtaagtga agagttgaat
     5881 acatctactc cacaacttcc cataaaagtc ttatcaaact tatatttcga tataaactct
     5941 atagttggag taccgacaaa accgtctaaa ctgagattta ataaacctcc agtggaaatt
     6001 atatttaaat tatttggttt tgaagtaact acatttagta tatccagcat atttgtaaca
     6061 agtgttactt ttttattact ttcagctaac aactttgcaa gcaagatgtt aattgtagag
     6121 atatctaaaa atatagtttc tctatcttca attaaattaa atgctttttc tgctattatt
     6181 ttctttgttg gaatattaat ttcttttctg tcttttgtat cctgattctc tagtgtttct
     6241 ctagctagta cagctcctcc ataaattctt cttattgaag aaatcttttc tatatttttt
     6301 aaatcttttc ttatacaatc ttctgtaaca ttaaatttag aactgagctc tttgacagta
     6361 actctacctt ctttttttag gatatttaat atagcttgga ttctttcttc tgcaaacatt
     6421 ttctacctct tttcgcaata tagtattata gtaaatatta taagataaa
//
LOCUS       DAEQCW010000153         6381 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.154, whole genome shotgun sequence.
ACCESSION   DAEQCW010000153 DAEQCW010000000
VERSION     DAEQCW010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6381)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6381)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6381
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.154"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            143..3322
                     /locus_tag="KRO40_003327"
     CDS             143..3322
                     /locus_tag="KRO40_003327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH2094123.1"
                     /translation="MKIDMIYKLIRRNTEPSRWSRGVKYYTHQLVDYIDIDIDDLQNN
                     LLTFRGGVNSEDNYSFYFNSITIDIKHFKIIENDCSCADCQSKGKSIFICKHIVAIVI
                     KSLKQIKNKKDVPPILIDILGADKDKLSNTNSKTSLDLSKQLLSLLDNTKRERVNLDV
                     LINVDSNKAIAEFKIGIDKMYILKNITEFAYSKLNGYELDFGKKFTYNPNIHYFADED
                     EKLVDIIEEYGTNLSYNFSSSHSKKFMEINASSLKQFLNAIKYKDFTLIFSKEEYHPK
                     ILNDTLPVRFDFKNIEDKIVLYSKDSLPVPLTKKNDVLLYDGNIYLLSHKKAHDYSKI
                     YQILSKTKELKFDKEDSKDVLGLLVPRLKSISQEVHLDDNIKNNITKDFKSEFYFDMI
                     DGNICCDVKYIYDDEDKKFVLPNIQKEATIENKLTSSQFTKENNHYVFKGTDHDLFTF
                     LDLQLESLKEFGDIYYSEKFKLKKIYNASSIQASINQTNQNYLEFNFNISDINPKEYK
                     DILKAFQEKRTFYKLKDGNFIDLSERETKDFFELVENLDIMDKSKNNKIHKNKALYIN
                     DVIRSKNLKFIDGKKELDSICEKFRNFDSINLEIPANLNANLRDYQINGLNWFKVLDY
                     YKFGGILADEMGLGKTIQTIAFLLSLSNKKSLIVTPTSLIYNWKNEFEKFAPDIKVLL
                     IHGNKRDREKCFMELENFDVILTTYGTLRNDLEKYSEIKFDYCILDEAQNIKNPVALV
                     TESVKSINAENKFALTGTPMENNLLELWSIFDFIMPGYLYSKAKFQELFINKEDNVKN
                     LKKLIKPFILRRSKKQVMKELPDKIEKNFFVELNKEQKKIYSVYSKDIQDKMKDKNLK
                     KDKIVIFSYLTKLRQLCLDPSIVVKDYNKKSSKIETCLEILRDSINENHKILLFSQFT
                     SVLKNISKELDKYKIKYHYIDGKTNAKERLELVDEFNNSMDKKVFLISLKAGGTGLNL
                     TSADMVIHFDPWWNPSVENQASDRAHRFGQKNSVQVIKLIAKGTIEEKIIKLQESKKE
                     LINQFINGELSNEGVLKSLSDEEIINLFN"
     gene            complement(3607..4371)
                     /locus_tag="KRO40_003328"
     CDS             complement(3607..4371)
                     /locus_tag="KRO40_003328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2094124.1"
                     /translation="MAYFNYNDKQCYYNEIGDGTPLLFLHGNTASSKMFNDIIDFYKD
                     EYKVILIDFVGHGKSQMVDKFSADLWFDEAMQVICFLEAMNYKKVNIIGSSGGALVAL
                     NVALERPDLVNKVIADSFEGEVPLESFVQNVKIEREASKQDDGAKAFYIYNQGENWEK
                     VVDNDTEAIFEHYKTIGKFFHKPLETMQPEVLLTGSREDEFVSLISSDFFENTFSLLL
                     EKIKNGKMYLFDKGGHPAILSNGLDFSNVAKKFLEE"
     gene            complement(4527..4760)
                     /locus_tag="KRO40_003329"
     CDS             complement(4527..4760)
                     /locus_tag="KRO40_003329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094125.1"
                     /translation="MKAEDMKRKVSPIDLERILVTGGVIKHEDSIWLLDFWGNKDIAG
                     ILLMPPTRHVILHLNDCCKWKEYFRTKKKFYRS"
     gene            complement(4834..6327)
                     /locus_tag="KRO40_003330"
     CDS             complement(4834..6327)
                     /locus_tag="KRO40_003330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH2094126.1"
                     /translation="MKYTFEKFKLNEKILKSLKSLGYNIPSRVQREVIPKLLKGQNLV
                     VRSKTGSGKTASFAIPLCENINVDYNNVQALIVVPTRELALQVKDEISDIGRLKKVRC
                     SAIFGKQSIKDQIAELKQRVHIVVATPGRILDHINRGSIKLENVKYLVIDEADKMFNK
                     GFVEQMEKILLNLPKEKIVSLFSATIDEEIKYICEKYMLDYSVINIEENESDTNQKTR
                     QIDDKIIKANGREKYILLKELIYSENPKSVIIFCNTKEKVSKLYNKMSKEGFLIRELH
                     ADLSQERRIFVIKDFKNQKFNILVSSDVASRGIHIDDISLVINYDVPQDKENYIHRIG
                     RTGRKGNSGKAITIVTEKDEKYIENIETYIGYKINELKDIEQSRITHGKVLFEEYSKG
                     VLKEVSKRKKVDKNSYKSKDIKLNIESEVVKLYLNAGKKKKIRVLDIVGAFSNIKGIT
                     NDDIGVIEVQDLCSYVDILNYKGDLILKKYKEIPIKKKMVKVKRDIR"
BASE COUNT         2368 a          907 c          741 g         2365 t
ORIGIN      
        1 aaatctaata gtaaattgtt atttacacat atattgtgat agataaaagc tattcatatc
       61 tgccttaatt ttagtcttaa atttagagtg taaattgaat gcatttagat tataatatat
      121 acagtgaggt aaggtgaata atatgaaaat agatatgata tataaactaa taagaagaaa
      181 tacagaacca tcaagatggt caagaggtgt aaaatattat actcatcaat tagttgatta
      241 tatagacata gatattgatg acctacaaaa taacctgttg acatttcgtg gtggagtcaa
      301 ttctgaagat aattatagct tttattttaa ttcaataact atagatataa agcactttaa
      361 gataattgaa aatgattgta gttgcgctga ctgtcaatca aagggcaaaa gtatttttat
      421 atgtaagcat atagttgcta ttgtgataaa aagcttaaaa caaataaaaa ataaaaaaga
      481 tgttcctcct attctaatag atatattagg tgcagataag gataagcttt ctaatacaaa
      541 ttctaaaacc agcttagatt taagcaagca attactttct ttgttagaca atactaaaag
      601 agaaagggtt aatttagatg tattgataaa tgtggattca aataaagcaa ttgctgaatt
      661 taaaatagga attgataaaa tgtacatttt aaaaaatatt actgaatttg catattcaaa
      721 acttaatgga tatgaattag attttgggaa gaaatttact tacaacccca acattcatta
      781 ttttgctgat gaagatgaga agttagtaga tattatagaa gaatatggga caaatctttc
      841 atacaacttt tcttcatcac attcaaaaaa atttatggag ataaatgcaa gctctttaaa
      901 acaattttta aatgctatta agtacaagga ttttaccctt attttttcta aagaggaata
      961 tcatccaaag atattaaatg atactctacc tgtaaggttt gattttaaaa atatagaaga
     1021 taaaatagtc ttatattcta aagattcact acctgttcca cttactaaaa aaaatgatgt
     1081 acttttatat gatggcaata tctatttatt atcacataaa aaagctcatg attattcaaa
     1141 aatatatcaa atattatcaa agactaaaga gttaaaattt gataaagagg attctaagga
     1201 tgttttagga ttgctagttc ctagattaaa atctatatct caagaagttc atttagatga
     1261 taacataaaa aataatataa caaaagattt taaatctgag ttctactttg atatgattga
     1321 tggcaacata tgttgtgatg taaagtatat atatgatgat gaagataaaa aatttgtgct
     1381 ccccaacata caaaaggaag ctactattga aaataaactt acttcttcac aatttacaaa
     1441 ggaaaataat cattatgtgt ttaaaggaac tgaccatgac ctatttacat ttttagattt
     1501 acaattagaa tctctaaagg aatttggaga tatatattat tctgagaagt ttaaattgaa
     1561 aaaaatatat aacgcttcat caattcaagc ttcaatcaat cagactaacc agaattacct
     1621 agaatttaat tttaatatat ctgatataaa tccaaaagag tacaaggata ttttgaaagc
     1681 ttttcaagaa aaacgtactt tttataaact taaagatgga aactttatag atttatcaga
     1741 aagagaaaca aaagattttt ttgaattagt tgaaaatcta gatataatgg ataaatcaaa
     1801 aaataataaa attcataaaa ataaagctct atatataaat gatgtaatac gtagtaaaaa
     1861 tttaaagttt atagatggta aaaaagaact agacagtata tgtgaaaaat ttagaaattt
     1921 tgatagcata aatttagaaa ttcccgcaaa tttaaatgca aaccttcgtg actatcaaat
     1981 aaatggcctc aattggttta aagttttaga ttattataaa tttggtggta tattagctga
     2041 tgaaatgggt cttggtaaaa caatacagac tattgcattt ttattatcat tatctaataa
     2101 aaaaagtctt attgttacac cgacatcact catttataat tggaaaaatg aatttgaaaa
     2161 gtttgctcca gatataaaag ttttattgat acatggaaat aaaagagata gagaaaaatg
     2221 ttttatggaa ttagaaaatt ttgatgtaat acttacaaca tatggtactc ttagaaatga
     2281 tttagaaaaa tatagtgaaa taaagtttga ttattgtata ttagacgaag ctcaaaatat
     2341 aaaaaatcca gtagctttag taactgagtc tgtaaaaagt ataaatgcag aaaataaatt
     2401 tgcactcact ggtacaccta tggaaaataa tctactagaa ttatggtcta tatttgattt
     2461 tataatgcct ggctatctat atagtaaagc aaagtttcag gaattgttta taaataaaga
     2521 agataatgtt aaaaacctga aaaaattgat aaaacctttt attcttagaa gaagtaaaaa
     2581 acaagttatg aaagaacttc cagataagat tgaaaaaaac ttttttgttg aattgaataa
     2641 agagcagaaa aagatatata gtgtatattc aaaagatata caagataaaa tgaaggataa
     2701 aaatttaaag aaagataaaa tagttatatt ttcttattta actaaactaa gacaactttg
     2761 tttagaccca agtatagtag taaaagatta caataaaaaa agttcaaaaa ttgaaacatg
     2821 tttagaaata cttagggata gtataaacga aaaccacaaa atattattgt tttcacaatt
     2881 tacttctgtg cttaagaaca taagtaagga acttgataag tataaaatta aataccatta
     2941 tatagatggt aaaactaatg ccaaagaaag acttgaactt gtagatgagt tcaataatag
     3001 tatggataaa aaagtttttt taatatcttt aaaagcaggc ggaactggtt taaatcttac
     3061 atctgctgac atggtaattc actttgaccc atggtggaat ccatcagtag aaaatcaagc
     3121 tagtgataga gctcatagat ttggtcaaaa aaattcagta caagttataa aattgattgc
     3181 taaagggact atagaagaaa aaataataaa attacaagaa agtaaaaaag agcttataaa
     3241 tcaatttata aatggagaac tttctaatga aggtgtatta aaaagtctat ctgatgagga
     3301 gataataaac ttatttaact aaattattta atcctacagc ttaactatat aaatttgttc
     3361 taacatttat atagttaagc taaaatatct gaataaataa aatttaatat tgttatttaa
     3421 tcccaacttt acaatctaat gatatctctt tctatacata ttgcatatac aaatgtaata
     3481 acttgactat tagaatattt tgttttaaca atactatttc atcataataa tgaagtatat
     3541 gtacactcac ttttgtaagt tttgcaatcc attttacagt tttcattatt gtaaattttg
     3601 gttaaattat tcctctaaaa atttctttgc tacatttgaa aaatctaatc cattcgataa
     3661 aattgcagga tgaccacctt tatcaaacaa atacatttta ccatttttaa tcttttcaag
     3721 aagtaatgaa aaagtatttt caaaaaaatc actagatatt agagatacaa actcatcttc
     3781 tctacttcct gttaaaagca cctctggttg catagtttct agaggcttat gaaaaaactt
     3841 tcctatagtt ttataatgtt caaaaatagc ttctgtatca ttatctacaa ctttttccca
     3901 gttttctcct tgattataaa tataaaaagc ttttgcacca tcatcttgct tagatgcttc
     3961 acgctctatt ttcacatttt gtacaaatga ctctagagga acttctcctt caaaactatc
     4021 tgcaattacc ttattcacta aatcaggtct ctcaagtgca acatttaatg caacaagagc
     4081 gcctccacta ctaccaatta tgtttacttt tttatagttc attgcttcta aaaaacatat
     4141 cacttgcata gcctcatcaa accataagtc agcagaaaat ttatcgacca tttgagattt
     4201 tccatgacct acaaaatcaa ttaatattac tttatattca tctttataaa aatcgattat
     4261 atcattaaac atcttggaag aggctgtatt tccatgtaaa aaaagtaatg gtgtaccatc
     4321 cccaatttca ttatagtagc actgtttgtc gttatagtta aaatatgcca tatatttccc
     4381 ccctttaata tccctatagg tatatattta ttacttatat ttaaaatgac tattccctta
     4441 gccacttaaa aatagtataa cttagaatat agataaaatc aacattcctt gctaatttat
     4501 ctattgtttg tctaatttat tataatttaa cttctgtaaa atttcttttt tgtacgaaaa
     4561 tattccttcc atttacaaca atcattcaaa tgaagtataa catgacgagt aggaggcata
     4621 agcaaaattc cagcaatatc tttgttcccc caaaagtcca acaaccaaat agaatcttca
     4681 tgctttatta ctcctccagt caccaaaatc ctttctaagt caattggaga gacctttcgt
     4741 ttcatatctt cagctttcaa atccttaaca acttctattg tgttttttgc aacttcattt
     4801 cgataacaaa gcaattcatc aatattgact aaattatcgt atatctcttt tcactttaac
     4861 catttttttc tttataggta tctccttata tttttttaat atcaaatctc ccttataatt
     4921 taatatatct acatatgaac ataaatcttg aacttcaatt acacctatat catcattagt
     4981 tatacctttt atattactaa atgcaccaac tatatctaaa actcttattt tcttcttctt
     5041 accagcattt aaatataatt taacaacttc actttctata tttagtttta tatctttact
     5101 tttgtaagaa tttttatcaa ctttttttct ctttgatact tcttttagta ctccttttga
     5161 atattcttca aacaaaactt tgccatgtgt aattctactt tgttctatat cttttaattc
     5221 atttatttta tatcctatat acgtttctat attctctata tatttttcat ccttttcagt
     5281 tactatagta attgcctttc cactatttcc ttttctccca gttctaccta ttctatgtat
     5341 atagttttct ttatcttgtg gcacatcata gtttattact aaagaaatat catcaatatg
     5401 tattcctctg gacgctacat cactactaac taatatatta aatttttggt ttttaaaatc
     5461 cttaattaca aaaattcttc tttcttgtga taaatctgca tgtaactctc ttattaaaaa
     5521 accttcttta ctcatcttat tatataattt agatactttc tctttggtat tacaaaatat
     5581 tatcacactc tttggatttt cgctgtatat taattctttt aaaaggatgt acttctctct
     5641 tccatttgcc ttgattattt tgtcatctat ttgtcttgtt ttttgattag tatcgctctc
     5701 attttcttct atatttataa cactgtaatc tagcatatat ttttcacata tatattttat
     5761 ctcttcatct attgtagctg aaaaaagact tactattttc tccttaggta aatttaataa
     5821 tattttttcc atttgttcaa caaaaccttt attaaacatt ttatctgcct catctattac
     5881 taaatacttt acattttcca acttaataga acctctattt atatggtcaa gtattctgcc
     5941 tggagtagct acaacaatat gaaccctttg tttcaattca gctatttggt cttttataga
     6001 ttgtttgcca aatatagcac tacatctcac cttctttagt ctccctatat ctgatatctc
     6061 atcttttact tgcaaggcta attctcttgt tggaaccact ataagagctt gaacattatt
     6121 gtaatctaca tttatattct cgcataaagg tattgcaaaa cttgctgtct ttccacttcc
     6181 tgtttttgac ctaactacta agttttgacc ttttaataat tttggaataa cttctctttg
     6241 tactctagaa ggtatattat atcctaaact cttcaatgac ttaagtatct tttcatttaa
     6301 cttaaatttt tcaaatgtat atttcatata ttaccacctt attatattta tcttatctat
     6361 atatttttct acattatatt a
//
LOCUS       DAEQCW010000154         6332 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.155, whole genome shotgun sequence.
ACCESSION   DAEQCW010000154 DAEQCW010000000
VERSION     DAEQCW010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6332)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6332)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6332
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.155"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(97..654)
                     /locus_tag="KRO40_003331"
     CDS             complement(97..654)
                     /locus_tag="KRO40_003331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBH2094127.1"
                     /translation="MTEKEKMLSGKGYYANDELLVKEREYCKKLTRLFNNTLEDEYEK
                     REDILRQLFGSVGKQINVEQNIRCDYGYNIHVGENFFANYDCIFLDVCKIEIGDNVML
                     APNVQIYTAYHPIDAQLRNSGIEYGSPIKIGDNVWIGGGVIITPGITIGDNVVIGAGS
                     VVTKDIPPNTVAVGNPCRVIKKIEE"
     gene            complement(660..1736)
                     /locus_tag="KRO40_003332"
     CDS             complement(660..1736)
                     /locus_tag="KRO40_003332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfate/molybdate ABC transporter ATP-binding
                     protein"
                     /protein_id="HBH2094128.1"
                     /translation="MSLYVDIEKDLSSFKLKVEIKQEKGTLGFLGESGSGKSMTLKCI
                     AGLEKPTRGKIVLNDRVLFDSEKKINLSTQDRKVGFLFQNYALFPHMTVSQNIELGLL
                     KLSKSEKKEIVARYLDILKLNGFEGRYPWQLSGGQQQRVALARALATSPDILLLDEPF
                     SALDHHLRSNMEKELMNMLKDYKGDILFVTHDIEEAYRVCDDIIVYNKGEGLPKRPKK
                     ELFESPKYLIEAKITGCKNISKLNRLDKNTIYATDWGCELTLNREIGDNIEYVGIREH
                     HIKVLDSNEDLNEKLCFELINIVENPFTYTIYVRKTDLSNECVPIQIELEKSKMRFKK
                     GDRIYLDFPQEYLFCFRYNYNKKE"
     gene            complement(1737..2420)
                     /gene="modB"
                     /locus_tag="KRO40_003333"
     CDS             complement(1737..2420)
                     /gene="modB"
                     /locus_tag="KRO40_003333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="HBH2094129.1"
                     /translation="MGTDWSPLWISLKTSILSTIITFVIGIFVSYIMANYRGKWKGLI
                     DGLFTLPLILPPTVVGFFLLLLCGKNGFIGKFLLNFDRTLIFSWTATVISAVVVSFPM
                     MYRTSRSAFEQIDNNMLSAARTLGLNEWKVFFKIAVPLAWSGIIGGLVLSFARALGEF
                     GATLMIAGNIPGKTQTMPIAIFFAVEGGDMNKAMMWVMIIVAISIAMILLLNYWSEFQ
                     QKIIGKRCG"
     gene            complement(2569..3381)
                     /gene="modA"
                     /locus_tag="KRO40_003334"
     CDS             complement(2569..3381)
                     /gene="modA"
                     /locus_tag="KRO40_003334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2094130.1"
                     /translation="MKKILGILGLVACLTLGTVGCNSNEDKKDDGKQEKTTKSSDSVE
                     LNISAAASLKEAMAKIEEEYKKVDSNVKLTVNYGASGSLQQQIEQGAPCDLFISAGQK
                     QMKALDEEKLLVSDTMKDLVKNDLVLISSADSSVSGMKDLTTDKVKKIAVGEAESVPA
                     GKYADEVLTNLNLKDKLKDKLVFAKDVKEVLAWVQSGNADVGFVYFSDTVNNDKIKVV
                     EKTDEKTHSPITYPVSVIKASKNVDAAKKFEEFLLSESGQKIFEEFGYKKVE"
     gene            3574..4503
                     /locus_tag="KRO40_003335"
     CDS             3574..4503
                     /locus_tag="KRO40_003335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094131.1"
                     /translation="MDSLSSLTPVEVAELLKITKNTVYELIKRGELPSYKVGKKIRVD
                     TKDVEEYINSQKTGKVKDTHFNNKNIDINNNFKIIISGQDVILDILARSVEKKLDGIS
                     TFRSYIGSYNALYELYNGRVSIASSHLWDFETDEYNSTFVKKLLPGIPCVLINLAYRM
                     QGFYVAKGNPKEITTWEDLTKPSITIVNREKGSGTRVLLDGKLRLLNFNGKHIKGYDN
                     EELSHLGVASTVSRGIADVGLGNEKAALQVNNIDFIPLHKERYDLVIKKEDLQNPVYQ
                     TIINIINSPEFKAELQGLGGYDLTDTGKTIAKV"
     gene            complement(4664..5113)
                     /locus_tag="KRO40_003336"
     CDS             complement(4664..5113)
                     /locus_tag="KRO40_003336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094132.1"
                     /translation="MKNKNNKDKNMLNIKVLRVLGVLLILFDYTGDTLNFYNFFAKPL
                     VSGNLYKTTGTDCIVFLLFIVECVYLVGRYILKVKINWSEIIENEKGNFINNLLVEKI
                     QEESNIVYNLLNSYVLPNIYKKARGLMFKTYHMLIYIKEKYYYVNIY"
     gene            complement(5316..6296)
                     /locus_tag="KRO40_003337"
     CDS             complement(5316..6296)
                     /locus_tag="KRO40_003337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2094133.1"
                     /translation="MKNSFKNCISLRNKFIIISIVFLLILLIVSYIFGKLVYNSSVGL
                     EQLIKNEDIVKIFSERKDKPLEKLKNYKTSELMIQSSNNYKLESLFITSNIKTRDTMI
                     LVHGIGSSYYEMLKVAYRYLDKGYNVLVYNQRNTGNSGGDNYTFGLYERYDLDSLVKF
                     VKNKFPEGRLGVHGFSMGAGTAAMHSEINSKDDKVDFYILDSPYSEMKDAIRMGVLEK
                     RIPDILINYVVTCGDLYNKFKSGFWYSDVKPYESVEKSNVPILFIHGTKDTVCNYQNS
                     KKMYDLVKHDKKDLWLIEGIGHVDGFEHDSTVYFNKIFKFIDSNVLSDKS"
BASE COUNT         2118 a         1104 c          670 g         2440 t
ORIGIN      
        1 tttttatttt aatgtattat ctatttaaag attatatgta aatgctctta atttgtttgt
       61 ataaatttta cttgtataaa ctttatacaa tcatatttat tcttctattt tctttattac
      121 tctacatgga tttccaacag ctacagtatt tggtggtata tcttttgtga ctacacttcc
      181 tgcacctatt actacattat cacctatagt aattcctggt gttatgatta ctcccccacc
      241 tatccataca ttatcaccta tttttatagg agaaccatac tctatgcctg aatttctaag
      301 ttgtgcatca attggatgat aggctgtata gatttgaacg tttggagcta acattacatt
      361 gtcacctatt tcaattttac atacatctaa aaaaatacaa tcataatttg caaagaaatt
      421 ttcgcctaca tgtatgttat atccataatc acacctaata ttttgttcta catttatttg
      481 cttgccaact gaaccaaata gttgtcttaa aatatcttct cttttttcat attcatcctc
      541 taaagtatta ttaaacaatc tagttaattt tttacaatac tctctttctt ttactaacaa
      601 ttcatcattt gcatagtatc ctttcccaga caacattttt tctttttcag tcatatagtt
      661 tactcctttt tgttataatt gtatctaaag caaaataaat attcctgtgg aaaatctaaa
      721 tatattctgt cacctttctt aaatctcatt ttactttttt ccaattctat ttgaataggt
      781 acacattcgt tagataaatc agtttttcta acatatatag tatatgtaaa aggattttct
      841 acaatgttaa tcaattcgaa acataacttt tcatttaaat cttcattaga atccaagacc
      901 ttaatatgat gctccctgat tcccacatat tctatattat cacctatttc tctatttaat
      961 gtcaactcgc atccccagtc tgtagcataa atagtatttt tatccagtct atttaatttg
     1021 gatatatttt tacaccctgt tatcttagct tctataaggt actttggaga ttcaaagagc
     1081 tcttttttag gtctctttgg aagaccttct cctttgttgt acactataat atcatcacaa
     1141 actcggtaag cttcttcaat atcatgagta acaaatagta tatctccctt gtaatctttt
     1201 aacatattca taagttcttt ttccatattg cttcttaaat gatggtccaa tgctgagaaa
     1261 ggttcatcta aaagtaatat atctggagat gttgccaatg ctctagctag tgctaccctt
     1321 tgttgttgac caccagataa ttgccaaggg tatctcccct caaacccatt taatttaagt
     1381 atatctaagt accttgctac tatttccttt ttttcactct tacttagttt taaaagccca
     1441 agttctatat tttgacttac agtcatatgt ggaaacaaag catagttttg aaataaaaat
     1501 cctacctttc tatcttgtgt tgataaattt atcttctttt cagaatcaaa tagaactcta
     1561 tcatttaata caattttacc tcttgttggt ttctcaagcc ctgctataca ttttaatgtc
     1621 atactttttc cagaaccaga ttctcccaaa aaccccagag tacctttttc ttgtttaatt
     1681 tctaccttta gtttaaaaga ggataaatct ttttcaatat ccacgtataa gctcaactat
     1741 ccacacctct ttcctataat tttctgctga aattccgacc aataatttag taataaaatc
     1801 attgctatag atattgctac aataatcata acccacatca tagctttatt catatctccg
     1861 ccttcaacag caaaaaatat agctattggc atagtttgag tttttccagg tatatttcca
     1921 gctatcataa gtgtagcacc aaattctcca agagctctgg caaacgacag caccaatcca
     1981 ccaattattc cagaccatgc taatggaact gcaatcttaa aaaatacttt ccattcatta
     2041 agacctaatg ttctagcagc tgacaacata ttattatcaa tctgttcaaa agctgacctt
     2101 gaagttctat acatcatagg aaaagacacc actactgctg aaattacagt tgctgtccaa
     2161 ctaaatatta aagtcctatc gaaatttaat aaaaactttc ctataaatcc attcttccca
     2221 catagtaata ataaaaagaa acctacaact gttggtggca aaattagtgg aagtgtaaat
     2281 agtccatcta taagaccctt ccacttacct ctatagttag ccataatata tgacacaaat
     2341 attcctatta caaaagttat tattgttgac aaaatagatg tcttaagtga tatccataag
     2401 ggtgaccaat ctgttcccat ctttccctcc ttaattttaa atggaaatag tgaaactaat
     2461 aactctatta atttcactat ttccatttta ttataataca caattatttt caattttcat
     2521 ttatttatat ataatttata cttaattaca cataatttat ttctaagttt attctacttt
     2581 tttatatcca aattcttcaa aaatcttttg tcctgactca cttaataaaa attcttcaaa
     2641 tttcttagca gcatctacgt ttttactagc tttaattact gaaactggat atgtaatagg
     2701 cgaatgagtt ttttcgtctg ttttttcaac tacttttatc ttatcattat tgacagtatc
     2761 actgaagtaa acgaatccaa catcagcatt tcctgattgc acccatgcta aaacttcttt
     2821 tacatctttt gcaaatacta gcttatcttt taacttatct tttaaattta aattagttaa
     2881 cacctcatct gcatacttac cagctggaac actttcagct tcaccaacag caattttctt
     2941 cactttatct gtagtcaaat ctttcatacc tgatacacta ctgtcagcag aagaaataag
     3001 aactaaatca ttttttacta aatctttcat agtatcagaa actaataact tctcttcatc
     3061 caaagctttc atttgttttt gacctgctga aataaataaa tcacaaggtg ctccttgttc
     3121 tatttgttgt tgtaatgagc ctgatgctcc atagttaact gtaagtttta catttgaatc
     3181 aactttttta tattcttctt caatctttgc cattgcttct tttaaacttg cagcagccga
     3241 tatatttaac tctactgaat cactactttt agttgttttt tcttgttttc catcatcttt
     3301 tttgtcttca ttactattgc acccaactgt ccccaaagtt aaacatgcaa ctaatcctaa
     3361 tattcccaat atttttttca taacaatctc cctttttgta aatttgatac acattttaac
     3421 atgttttatt atgttttatc atgttttgtt atatatagtt taattatata tacatgataa
     3481 taaattttca agtaatttat ttacactact tttaaatatt ttgctacatt ttcctttttt
     3541 taatgttaaa ataaccttat atggaggtgg attatggact cattatcatc tttgacacct
     3601 gtcgaggtag ctgaattatt aaagataaca aaaaatactg tatatgaatt aatcaaaaga
     3661 ggtgaacttc cttcttataa agtagggaaa aaaataagag ttgatactaa agatgttgaa
     3721 gaatatatca acagccaaaa aactggtaaa gtaaaggata cacatttcaa caataaaaat
     3781 atagatataa ataataattt caaaattatt atttctggtc aagatgtaat attagacatt
     3841 ttagctaggt ctgttgaaaa aaaattggat ggaataagta catttcgctc ttatataggt
     3901 agttataatg ctttgtatga gttatataat ggcagagttt ctatagcatc atcccatcta
     3961 tgggatttcg aaacggatga atataatagc acttttgtta aaaagctatt gccaggaata
     4021 ccatgtgtac ttataaatct agcttataga atgcaaggtt tctatgttgc taaaggaaat
     4081 cctaaagaga taacaacctg ggaggattta acaaaaccaa gtataaccat tgtaaatagg
     4141 gaaaaaggtt ctggaactag ggttttacta gatggtaaac ttagacttct aaactttaat
     4201 ggtaaacata taaaaggtta tgataatgaa gaattatcac atcttggagt tgcaagtact
     4261 gtttctcgtg gaatagcaga tgttggtttg ggaaatgaaa aagctgcttt acaagtaaat
     4321 aatatcgact ttattcctct tcacaaagag cgctatgatt tagttattaa aaaagaagac
     4381 ttacaaaatc cagtttacca aactataatt aacataataa actctcctga gtttaaagct
     4441 gaacttcaag gtcttggcgg atatgattta actgatactg gaaaaactat agcaaaagtt
     4501 taagattaaa atcgcaatct attttataag atttataatt tttcacaaaa tttataactt
     4561 aaacacgaaa taaattgcga ttttagtgtc tcaaaaaatt tatgtctttc attttatcat
     4621 ccaatacaaa atataatata attaattgtg caatcatatt atattaatat atatttacat
     4681 aatagtattt ttctttaatg tagattaaca tatgatatgt tttaaacatc aatccccttg
     4741 ctttcttata tatatttggc aacacatatg agtttaataa attatataca atgttgcttt
     4801 cttcttgtat tttttcaacc aacaagttat ttataaaatt acctttctca ttttcaataa
     4861 tctcactcca atttatctta acttttaata tatatcttcc cactaggtat acacactcta
     4921 caataaataa taaaaataca atgcagtcag tacctgttgt cttatataaa ttacccgata
     4981 ctaatggctt tgcgaagaaa ttataaaaat tcaaagtatc acccgtataa tcaaaaagta
     5041 ttaatagcac tcctagaact ctcaatactt taatattcaa catgttttta tctttattat
     5101 ttttgttttt catatatact acctctcttt tctttagatt tgattgtaat ctaatactaa
     5161 ctcttttatt tgaggtataa atgaatttaa ttggtagtta ttttcatttt tactagaaat
     5221 taattcacat tactaaacaa aacttatatt taaacataaa aatagcctat ctatctttta
     5281 ataaatacaa aaataaataa gctactaata ttcaattaac ttttatcact taaaacatta
     5341 ctatctataa atttaaatat tttattgaag tatactgtac tatcatgttc aaatccatca
     5401 acatgaccaa taccttctat aagccatagg tcttttttat catgtttaac taaatcatac
     5461 attttcttgc tattttgata attacaaaca gtatcttttg ttccatgtat aaacagtatg
     5521 ggtacattag atttctcaac tgactcatat ggttttacat cactgtacca aaatccagat
     5581 ttaaacttat tatataaatc tccacaagtc accacataat tgattaatat atctggtatt
     5641 cgtttttcta gtactcccat tctaattgca tctttcattt cagaataagg agaatccagt
     5701 atataaaaat cgaccttatc atcttttgaa tttatctctg aatgcatagc agctgtccct
     5761 gcccccatgg aaaatccatg cactcctaat ctcccttcag gaaatttatt ttttacaaat
     5821 ttaactagac tatctaaatc atacctttca taaagaccaa atgtgtaatt atctccacca
     5881 ctattaccag tatttctttg attataaact aatacattat aacctttatc taaatatcta
     5941 tatgctacct ttaacatttc atagtaacta cttccaattc catgaacaag tatcatagta
     6001 tctcttgtct ttatatttga agttataaaa agactttcaa gcttgtaatt attagaactt
     6061 tgtatcatta attcagatgt cttgtagttt tttaatttct ccagtggttt atcttttctc
     6121 tcagaaaata tttttactat atcttcgttt tttattaact gctctaaacc aactgaacta
     6181 ttatacacta attttccaaa tatataagat acaattaata ggattaatag aaacacaatt
     6241 gatataatta taaatttatt tcttaaacta atacaatttt taaaactatt tttcatattt
     6301 atttaccata caattttcct atattatatt tt
//
LOCUS       DAEQCW010000155         6136 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.156, whole genome shotgun sequence.
ACCESSION   DAEQCW010000155 DAEQCW010000000
VERSION     DAEQCW010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6136)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6136)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6136
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.156"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(43..447)
                     /locus_tag="KRO40_003338"
     CDS             complement(43..447)
                     /locus_tag="KRO40_003338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBH2094134.1"
                     /translation="MIKITIPGRPISKSNFKLHNINGQAWMPSKGKYSKYLAYENMIA
                     GFINQQYQGETVEENLITVLKLFFPNKRMGDLHNYPKSICDGIEKSGIIKNDKQLKPV
                     LLFDFIDKDNPRVEIELYPVSKYDISYNIFEK"
     gene            1544..2458
                     /gene="queG"
                     /locus_tag="KRO40_003339"
     CDS             1544..2458
                     /gene="queG"
                     /locus_tag="KRO40_003339"
                     /EC_number="1.17.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA epoxyqueuosine(34) reductase QueG"
                     /protein_id="HBH2094135.1"
                     /translation="MDNKELKAFCNLIGLNCVGVAGVDKYDNLEKILKDRQQKGYLTG
                     MEEPIIENRINPRHIMKDANSIIVCAFPYHINRQEKNKNSNLSKYCHGKDYHIVVKDF
                     LQQICDYISKTVTDFKYKLFADNGPLVDRYLAYLSGIGYFGINNNIITDEYGSYVFIG
                     YIVNNYKFEEDKPLEKSCFKCGKCVKYCPGNAILGNYDMNPKKCLSYITQKKGDLSEK
                     EKVVLKNGKKVFGCDICQEVCPHNVEIPTTHILEFKENIIDYLDYDEIQNISNKEFKR
                     RYGDRAFSWRGRNIIKRNMEIILDKYDD"
     gene            2564..4801
                     /locus_tag="KRO40_003340"
     CDS             2564..4801
                     /locus_tag="KRO40_003340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2094136.1"
                     /translation="MKYNNTSEINPLDYILGQERAVEAMELGLKINNPAYNIYIAGEP
                     GTGKSTYALKVLNEYASKKNTHKDWCYIYNFENPREPIIVELEKGFGRELKKDMEKLI
                     ESLLEDFKNAFESENFEIEKNKLLDEYEIEKDMLLKQIKKYGEEKGFKLKQSKMGIVF
                     IPLKEEEDESDESDEEFYKAKRELENMAIQVVYKIRNLEEIAEKAVLELEEEIAKLVV
                     EPHIKRLCEKYENYDKIQTYLENIKKDIIEYMYLFYLDEEELKDKYDKEHFIKYKINL
                     FVDNGSSKNKESAPVVVEINPSPANLFGKAEYDYANGNIKTDFTKLLSGAFHRANGGY
                     LVLYADQLLKYTMSWEILKKTLQTKKVILETQTAIKPENMPLDVKLVLIGSHYIYDIL
                     YRYDEDFEKYFKVFVDFDSEMDKNEDNEEGIARFIAYQCDKNNLRHFTKSAVEEVIKF
                     STRLSGDLEKLSTKFNKIMEVVIEGSAYAEFRNSEYTEQCDVKKAISEKRKRINRVET
                     HMDESIENGFTLIETEGRKVGVINGLSVLSTGEYSFGRASRITATTSPGSKGIVNIER
                     EVNMSGSIHNKGVLILGGYLSENFAQDLLLSLNAYVCFEQNYGGIDGDSASSAELYVL
                     LSSLSGVSIKQNIAVTGSINQKGDIQVVGGISEKIEGFYSICKTKGLNGEQGVIIPRK
                     NQRNLVLSDEVNDAVRDGKFKIYTVERVEEAIEILTDVKFEEIKKLVKEKLISFSKIQ
                     TVSKE"
     gene            4998..6050
                     /gene="nth"
                     /locus_tag="KRO40_003341"
     CDS             4998..6050
                     /gene="nth"
                     /locus_tag="KRO40_003341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HBH2094137.1"
                     /translation="MKNVNLKEINEKDVIVEEDINLKGMDKKDVIEKEEVNKKSIDKK
                     DIIEKEEIDKKNVKKVEVQKGIDKMIGKKDEIIDEKDIENFMDIEEDKKSIKVSKKST
                     KKGETEKKTKKSSSNKATQKTSKETKSKSKIKNESANEKDVNKILDELEKLYPDAKCE
                     LNYGTAFELLIATILSAQCTDVRVNKVTSELFKKYNTARDFANLSIEEISKEIKSCGL
                     YKSKSQKIKDTSEQLCELYDGEVPDSLEKLIKLPGVGRKTAGVVLSNAFNHPAIAVDT
                     HVFRVSNRIGIVDEPNPQKTEFALMETIPKERWSHSHHVLIFHGRRMCKARNPECASC
                     PIKEDCNYYKELNETK"
BASE COUNT         2648 a          527 c         1114 g         1847 t
ORIGIN      
        1 atactggagt atcaatataa tgtcgaataa cacataaaat ctttattttt caaaaatatt
       61 ataggatata tcgtatttag atactggata aagttcaatt tcaaccctag ggttatcttt
      121 atctataaaa tcaaataaaa gtactggctt aagttgttta tcatttttta ttattccact
      181 tttttcaata ccatcacaaa tactttttgg ataattatgt aaatccccca ttctcttatt
      241 tgggaagaat aatttcaaga ctgttattag attttcttca acagtttccc cttgatactg
      301 ttggtttata aaacctgcaa tcatgttttc gtatgcaaga tacttagaat attttccctt
      361 tgaaggcatc catgcttgac catttatgtt atgaagctta aaattagatt tactaatagg
      421 tctacctgga attgttattt taatcaaatt tttcaccatc cttatacagt atttattata
      481 atctgtatat gatttaaaag caaattgtta tttaaagtgt tttacagagc ttttttgtaa
      541 aattttccac tttagatgta gtaatataag ataagtattt tgcttacaaa ttttaaaatt
      601 tgatatatga tggacatatt catattagac tattataaga cctttataat attaataagt
      661 atagtttagt aaagagagta aaaagaaatc catataagtc aagtaaagac ttaataaatg
      721 gcaatgtaaa tgggatatta attataagaa aaaatcaatc tttttgctta actatagaaa
      781 aaatgtcaaa atataactaa tgatatttga agttttagag tttatattaa aaggtaagaa
      841 ggttaagtgg gtaaaaaagg ttgaatagat taaaaaggct aagtatctaa aagagttaag
      901 taggtaaaaa agttaaataa gtaaatgaaa aaggctaagt atctaaaaga gttagtaggt
      961 aaaaaagtta aataagtaaa tgaaaaaggc taagtatata aaggagttag tagataaaaa
     1021 aattaagtat ctaaaagcgt tagtagataa aaaaattaaa taaataaaaa agactaagta
     1081 ttcaaaagag ttagtaggta aaataattaa atagataaaa agactaatta tttaaaggag
     1141 ttaagtagat aaaaaagtta aataagtaaa tgaaaaagac gaagtatcta aaagagttag
     1201 taaataaaaa agatgaagta tctaaaagag ttagtaaata aaaaagatga agtatctaaa
     1261 agagttagta ggtaaaaaac taaataggta aaaagatgaa gtatctaaaa gagttagtag
     1321 gtaaaaaatt aaataggtaa aaagacgaag tacctaaaag agttagtagg taaaaaaatt
     1381 aaatagataa aaagacgaag tatctaaaag agttaagcag gtaagaaaat tgaatagcta
     1441 aaaagattaa gtatttaaaa gagttagtag ctagaaaagg ttaaaaagac taaaaaaatt
     1501 aaataaattt aaaaagtcaa ttagattaaa aaggaataat tttatggata ataaggaatt
     1561 aaaagcattt tgtaatttaa taggattaaa ctgtgtagga gtagcagggg tagataagta
     1621 tgataattta gaaaagatac ttaaggacag acaacaaaaa ggttatttaa ctggtatgga
     1681 agaaccaata attgagaaca gaattaaccc aagacatata atgaaggatg ctaactctat
     1741 aatagtctgt gcatttccat atcatataaa tagacaagaa aagaataaaa attcaaattt
     1801 atcaaaatat tgtcatggaa aggattatca cattgtagta aaggactttt tacaacaaat
     1861 ttgtgattat atttctaaaa cagtaacaga ttttaaatac aagttatttg ctgataatgg
     1921 accattagtt gacaggtatt tagcttattt atcaggaata ggatattttg gaataaataa
     1981 taatatcata actgatgaat atggttctta cgtatttata gggtatatag taaataatta
     2041 taaatttgaa gaagataaac cactagaaaa aagttgtttt aaatgtggta agtgtgtaaa
     2101 atattgtccg ggaaatgcta tattgggaaa ttatgatatg aaccccaaaa aatgtttatc
     2161 atatataact caaaaaaaag gagatttgtc agagaaagaa aaagttgttt taaagaatgg
     2221 caaaaaggta tttggatgcg atatttgtca agaagtatgt ccacataatg ttgaaatacc
     2281 aacaactcat attttggaat ttaaagaaaa tataatagac tatttggatt atgatgagat
     2341 acaaaatatt tcaaataaag aatttaaaag gagatatgga gatagagctt ttagctggag
     2401 agggagaaat ataataaaga gaaatatgga aataatttta gataagtatg atgactaata
     2461 ataagagtct gtttcatata ctttaatgtg tatttacttt aacacttgtt gtgtaaaagt
     2521 catattatat cattaaagtt aaatatgggg aggtggggga atattgaaat ataataatac
     2581 atctgaaata aatccactag attatatatt gggtcaagaa agagctgtag aagctatgga
     2641 attagggttg aaaataaata atccagcgta caacatatat atagctggtg aacctggaac
     2701 tggtaaaagt acttatgcct taaaggtttt aaatgagtat gcatccaaaa aaaatacgca
     2761 taaagattgg tgttatatat ataattttga aaaccctaga gagcctatta tagttgaatt
     2821 agaaaagggg tttggaagag aacttaaaaa agatatggag aaattaattg aaagtctttt
     2881 agaagatttt aaaaatgcgt ttgaaagtga aaattttgaa atagaaaaaa ataaacttct
     2941 ggatgaatat gaaatagaaa aagatatgct tttgaagcaa attaagaaat atggagaaga
     3001 aaaaggattt aaattaaaac agagtaaaat gggaatagtt tttatccctt tgaaagaaga
     3061 ggaagatgaa agtgatgagt ctgatgaaga gttttacaaa gctaaaagag aactagaaaa
     3121 tatggcgata caggtcgtat ataaaattag aaacttagaa gaaatagctg aaaaagcagt
     3181 gttagagctt gaagaagaga tagctaaact tgtagtagaa cctcatatca agagattgtg
     3241 tgaaaaatat gaaaattatg ataagattca aacttatctg gaaaatataa agaaagatat
     3301 aatagaatat atgtatttat tctatttaga tgaagaggag ttaaaagata agtatgataa
     3361 agaacatttt attaaatata aaattaacct atttgtagac aatggaagct caaagaataa
     3421 agaatcagca cctgttgtag tagagataaa cccaagtcca gcaaatctat ttggaaaggc
     3481 agagtatgat tatgcaaatg gaaatataaa gactgatttc acaaaactat tatcaggagc
     3541 atttcatagg gctaatggtg gttatttagt actttatgca gaccaattac taaaatatac
     3601 aatgtcttgg gaaattctta aaaagacttt gcagactaaa aaagtaatat tggaaacaca
     3661 aacagcaatt aaaccagaaa atatgccatt ggatgttaaa ttagtactga ttggaagcca
     3721 ttatatatat gatattttat atagatatga tgaagatttt gaaaaatatt ttaaagtatt
     3781 tgtagacttt gatagtgaaa tggataaaaa tgaagataat gaagaaggaa tagcaagatt
     3841 tatagcatac caatgtgata agaataattt aaggcatttt actaaatcag cagttgaaga
     3901 ggttattaaa tttagcacta gattatctgg tgatttagaa aaactatcaa ctaagtttaa
     3961 taaaataatg gaagttgtaa tagaaggaag tgcttatgca gagtttagaa attcggagta
     4021 tacagagcag tgtgatgtta aaaaagcaat aagtgaaaag agaaaaagaa tcaatagagt
     4081 ggaaacacat atggatgaat caattgaaaa tggatttact ctaatagaaa cagagggaag
     4141 aaaagtaggc gtgataaatg gtctgtcagt cttaagtaca ggagaatact cttttggtag
     4201 agcttcaaga attacagcga ccactagccc aggaagtaaa ggcatagtaa atatagaaag
     4261 agaagtaaat atgagtggct ctatacataa caaaggagta cttatattag gtggctatct
     4321 ttctgagaat tttgcacagg atttactatt gtcactaaat gcatatgttt gttttgaaca
     4381 aaattatggt ggaatagatg gagatagtgc atcttctgca gaattatatg tactattatc
     4441 atctcttagt ggagtatcaa ttaaacaaaa tattgctgtt acaggttcta taaatcaaaa
     4501 gggtgatata caagtagttg gtggtataag tgaaaagata gaaggatttt attctatatg
     4561 taaaactaaa gggttaaatg gtgagcaagg tgtcataatt cctagaaaaa atcaaagaaa
     4621 tctcgtttta tcagatgaag ttaatgatgc agtgcgagat ggaaaattta agatatatac
     4681 tgttgaaaga gtagaagagg ctatagagat attgacagat gttaaatttg aagaaataaa
     4741 gaaattggta aaagaaaaat taatatcttt cagcaagata caaactgtgt caaaagaata
     4801 agtttattat agaatttaat gggtatttat gtataataaa aagcaagaac tttaataggt
     4861 ttttgctttt tttgtaaata tatataaatt aaattcttat tttgtatgtt ttatatattg
     4921 atgtttattt tttgttgata tgattaaact atttataaat agcgttttat aaattagtat
     4981 tttaaagggg gataattatg aaaaatgtaa atctaaaaga gataaatgaa aaagatgtaa
     5041 ttgtggaaga agatataaat ctaaaaggaa tggataagaa agatgtaatt gagaaggaag
     5101 aagtaaataa aaaaagtata gataagaaag atataattga gaaagaagag atagataaaa
     5161 aaaatgtaaa gaaggtcgag gttcaaaaag gaatagataa aatgattggt aaaaaagatg
     5221 agataattga tgagaaagat atagagaatt ttatggatat tgaagaagat aaaaaaagta
     5281 tcaaagtaag taaaaaaagt actaaaaaag gtgaaacgga gaaaaaaaca aagaagagta
     5341 gttctaataa ggctacacaa aaaacaagta aagaaactaa aagtaagtct aaaattaaaa
     5401 atgagtcagc aaatgaaaaa gacgtaaata agattttaga cgagttagaa aaattgtatc
     5461 cagatgctaa atgtgagtta aattatggga cagcctttga acttttaata gcaactattt
     5521 tatcagcaca atgtactgat gtaagagtga ataaagttac ttcagagttg tttaaaaagt
     5581 acaacacagc tagagacttt gctaatttga gcattgaaga aattagtaaa gagataaaga
     5641 gttgtggtct ttacaaaagc aagtctcaaa aaataaagga tacatctgaa cagctatgtg
     5701 aattatatga tggtgaagta cctgatagct tagaaaagct tataaaatta cctggtgttg
     5761 gaagaaaaac ggcaggggtt gtacttagta acgcttttaa tcatccagca atagctgtag
     5821 atactcatgt atttagagtt agcaatagaa taggaatagt ggacgagcca aatcctcaaa
     5881 aaacagaatt tgcacttatg gaaactatac caaaagaaag atggtcacac tcacatcatg
     5941 tattaatttt tcatggaaga agaatgtgta aagctagaaa tccagaatgt gcaagttgcc
     6001 caataaaaga agattgtaat tattataaag aacttaatga aacgaaataa cttttagaaa
     6061 gtaagttgta caagagggat tttctgatat aataatactt gtgaaaatgt tagataaaaa
     6121 actattatat acatga
//
LOCUS       DAEQCW010000156         6088 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.157, whole genome shotgun sequence.
ACCESSION   DAEQCW010000156 DAEQCW010000000
VERSION     DAEQCW010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6088)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6088)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6088
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.157"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(166..1524)
                     /locus_tag="KRO40_003342"
     CDS             complement(166..1524)
                     /locus_tag="KRO40_003342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2094138.1"
                     /translation="MFIRKNVIKLAIPIMIEQTFVMLLGVFNTMMAGHIGEEAVSAVG
                     MVDSINNIFISVFAALSVGATVVVAQQIGKKDSEKVNETIKQALVSGVILSFTITILM
                     WVFRTGVINLFYGSAEELVKSNAKLYIEFTLFTYPFIATQQIANGILRGCGDVKKPMY
                     VTMFMNIVNVTLGYILIYGIDLNPLGINLQTPSYGITGAAISIAIARIIGCIVIIRAL
                     FKGNEFISMGKIFPFKIDVETQKSIFNIGIPAGVEQLLFNAGKLIVQVFIVTMGTSAI
                     ASNAIGMSIASIINVIGNALALSATTLVGQYIGRGDIKGAKSTLLYLTKFATICLFIV
                     GAIFIPIAPWISSMYTQNASVIDISTQLIRSDCLAMVIWPISFVLSAGLKGAGDTRYT
                     MMTAVIGMWIFRIFTGYVLGVVLEFGVLGIWIGMYTDWLVRGALYCLRLRGTKWLKHK
                     VA"
     gene            1972..2424
                     /locus_tag="KRO40_003343"
     CDS             1972..2424
                     /locus_tag="KRO40_003343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="staygreen family protein"
                     /protein_id="HBH2094139.1"
                     /translation="MVNLNANNLNVNMVYPISSTAPIRFRRYTVSYLENMENIYLTIA
                     TYFDTLGLGTMNIDKVYGQWAWFTDNIYDLNLFVFVGNYPYQIAKNRYDTFVDILPVA
                     ITSIVNGDRVFLISNPCLLNSKITVRFISSHPTLNRTVDYGNIRDFIF"
     gene            complement(2581..3198)
                     /locus_tag="KRO40_003344"
     CDS             complement(2581..3198)
                     /locus_tag="KRO40_003344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF488 domain-containing protein"
                     /protein_id="HBH2094140.1"
                     /translation="MEIFAIGHSNYPYDKLINMIKKYDINCVVDIRETPYSKYNIQYN
                     KEAFNESLRNSGFIYIYMGKEFGAKRTNKDVYTQEGYADFEKVAKEDIFLNGIERLKK
                     GCQMGYRIVLLGAMQEPIRCHRSILVGKVLNKEGFDVKYIMHEGNLAYQEDIEESLLD
                     KYFSDRKQLSIDNLLGSALTREEMIQEGYKLANKEIGYRTEKLGK"
     gene            complement(3621..4433)
                     /locus_tag="KRO40_003345"
     CDS             complement(3621..4433)
                     /locus_tag="KRO40_003345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2094141.1"
                     /translation="MFSIGMFSKINKITTKTLRYYEDIGLLKPEYVDEFTKYRYYTTE
                     QLPKLHQIITLKQMGLSLAEIKKAVENPEEVENILMNKEKEMLDVIKSEEYKIIKLRN
                     YLMNLKGEVNMNDVIIKSLPKVKVASMRKVLKGYDELFNLFPNVMAEEMMKTGCTCAV
                     PDYCFNIYHDGEYRETDMDVEMCQAINDLKEDTDILKFKELDAVENAVCILHNGPYST
                     LGKTYADAFKWIEDNKYKVVGNPRESYIDGIWNKESEEDWLTEVQIPVKRML"
     gene            complement(4509..5927)
                     /locus_tag="KRO40_003346"
     CDS             complement(4509..5927)
                     /locus_tag="KRO40_003346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium/proton antiporter"
                     /protein_id="HBH2094142.1"
                     /translation="MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDG
                     MVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMAKPVAIPSILMSSLGVIITAGVT
                     GMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP
                     IAYMLTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFY
                     TIFITAIAILSYAFSEYLGGNGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIM
                     LFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLAKFKFSNKEKLFISWVG
                     LRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDNTP
                     VLKTFNDYDGEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGS
                     TIIKTGDILVLSGDRIEELIQL"
BASE COUNT         2101 a         1062 c          607 g         2318 t
ORIGIN      
        1 aaattatgta attctgctca atatataatt tataatatcc atactattat agcctttatt
       61 tatgtaattt aatcacctta tatatcatac ttataattat gataataact acataaaaaa
      121 tcacttctaa atagagttat ccatctaaaa gtgatttcat atattctatg caactttgtg
      181 ttttagccac tttgttcctc ttaatcttaa acaatataaa gcccctctaa caagccaatc
      241 agtatacata cctatccaaa ttcctaacac tccaaattct aatacaaccc ccaatacgta
      301 acctgtaaaa attctaaaaa tccacatacc tattactgca gtcatcattg tatatctagt
      361 atcaccggct ccctttaacc ctgctgataa tacaaaggat ataggccata ttaccatagc
      421 taaacaatca cttcgaatta attgtgttga gatgtcaatt acactagcat tttgagtata
      481 catacttgaa atccagggtg caattggtat aaatatagct cctactataa ataaacaaat
      541 tgttgcaaat ttagttaaat ataataaagt actcttagct cctttaatat ctccacgtcc
      601 tatatactgt cccaccaagg ttgtagcaga caaagctaaa gcattcccaa ttacatttat
      661 tatggatgca attgacattc ctattgcatt ggatgcaatt gctgatgttc ccatagtaac
      721 tataaatact tgaacaatca atttacctgc attaaaaagt agttgttcaa ctccagctgg
      781 tattcctata ttaaatatag acttttgagt ttcaacatca atcttaaatg gaaatatttt
      841 acccatagat ataaattcgt ttcctttaaa taaagctctt ataattacta tacatccaat
      901 tattctagct atagcaatag atatagctgc acctgttatg ccataggatg gtgtttgcaa
      961 atttattcct agaggattta aatcaatacc atatataagt atatatccca atgttacatt
     1021 tactatattc ataaacatag tcacatacat aggtttcttt acatctccac accctcttaa
     1081 aataccattt gctatttgtt gtgtcgcaat aaatggatac gtaaataatg taaactctat
     1141 gtataatttt gcatttgatt ttaccaattc ttctgctgaa ccataaaata aattaattac
     1201 accagttcta aaaacccaca tcaatattgt tattgtaaag gataatatta ctccagacac
     1261 tagagcctgc ttaatagttt cattcacctt ttcactatct ttttttccta tttgttgagc
     1321 tacaacaaca gtagctccaa cagatagtgc agcaaataca gatataaata tattgtttat
     1381 tgaatcaacc attccaactg cagatacagc ttcttcccca atatgacctg ccatcattgt
     1441 attaaatact cctaaaagca tgacaaacgt ctgctctatc attataggaa ttgctaactt
     1501 tataacattt ttccttataa acatccctat tcctcttttc cctctttata taaatttaat
     1561 ttttaattag tttatcgaac tgtaaattga caatgcaaag tttagaattg tatcgttcgc
     1621 attataatat actgctttca aataatataa atcttgttta atatcatttg aacacagtat
     1681 atctttataa ttatcttatg tttattattt tttatggata ccacatttaa aatatttatt
     1741 aatttaatat aaatattttc cgttattatt aaaagtagct atatttcgtt aatattgtat
     1801 cactatcgtg tagcaataac aataagtaca ttttatatat tttttataat attatttaat
     1861 catccaaact tttaccactt tttcaatata taaaatatta cactttagat gtaacaaaat
     1921 cgcatccatt taaatattgt attttataga ctaattttag gatgtgatac tttggttaat
     1981 ttaaatgcaa ataatctaaa tgtaaatatg gtttatccta tttcttccac agcacccata
     2041 cgtttcagaa gatatactgt ttcatattta gaaaacatgg aaaatattta tttaactata
     2101 gcaacatact ttgatacact tggtttaggc acaatgaata tcgacaaagt ttatggtcaa
     2161 tgggcttggt ttactgataa tatatatgat ttaaatctat ttgtttttgt aggaaattat
     2221 ccttatcaaa ttgctaaaaa cagatatgat acatttgtag atattttgcc agtagctatt
     2281 acttctattg tcaatggaga tagagtattt ttaatttcaa atccttgttt gttaaattca
     2341 aaaattacag ttagatttat atctagtcat cctactctta atagaacagt tgattatggc
     2401 aatattagag attttatttt ttaaaactgc aacatgatgt gctattaaaa aataccctaa
     2461 atttaatgat attattaaat aactagaata tttttaattg gcacatcatg cctagctatt
     2521 ataaattcat aatattattt tacttaagat aagtactgta ttttatctac ttgtatattt
     2581 ttatttacct agtttctcag ttctatatcc tatttcttta ttagctagct tataaccttc
     2641 ttgtatcatt tcttctctcg ttaatgcact ccctaataaa ttgtcaatac tcagttgctt
     2701 tctatcacta aaatacttat ccaataatga ttcctctata tcttcctgat atgccaaatt
     2761 tccttcatgc attatatatt ttacatcaaa accttcttta tttaatactt ttcccaccaa
     2821 gatacttcta tgacatctta taggttcttg catagctcct aataaaacta tcctataacc
     2881 catttgacaa ccctttttta atctttctat tccgtttaaa aaaatatctt cttttgctac
     2941 tttctcaaaa tctgcataac cttcttgcgt atatacatct ttattagttc ttttagctcc
     3001 aaattctttt cccatgtata tatatataaa tccggaattt ctaagagatt cgttaaatgc
     3061 ctctttattg tattgaatat tatatttaga atatggagtt tctctaatgt caactacaca
     3121 atttatgtca tattttttta tcatattaat aagcttatca tatggataat ttgaatgtcc
     3181 tattgcgaat atttccatat aaacaccctc ctattctttg aaattagtat ctatatatgt
     3241 agatacccga tttacttaaa attaaataaa gtattacttt aaatacccaa tatctttttt
     3301 tcttgatatt gtatattttt ttactttata tccttaaaaa aatatacaac tttatatata
     3361 aaacatcaat atttatatat attttgtata ttaaatacaa ttatttataa agtctttaat
     3421 aaaaatttat aaatagagca tctttagaaa actattataa taaaaaaata agaggctgtc
     3481 taaaaatata gataagcctt ttttcataat cgtaattata aaaatatact tgatttcata
     3541 tgaaaaagag tgtctcataa actaaaatgt ttactttgag acaccacctt ttttattctt
     3601 atttatactt tgtagacata ttataacatg cgtttcactg gtatctgaac ttctgtcaac
     3661 cagtcttctt cactctcttt attccatata ccatctatat aagattctct aggatttcca
     3721 accactttat atttattgtc ctctatccat ttaaatgcat ctgcgtaagt ttttcctaat
     3781 gttgaatatg gaccattgtg taatatacaa actgcatttt caactgcatc taattcttta
     3841 aattttaata tatccgtatc ttcctttaaa tcatttatag cttgacacat ttcaacatcc
     3901 atatcagtct ctctatattc accatcatga tatatattaa aacaataatc aggaactgca
     3961 catgtacacc ctgttttcat catttcttca gccattacat ttggaaatag attaaaaagt
     4021 tcatcatacc cctttaacac ttttctcata gaagcaactt taacttttgg taaagactta
     4081 ataattacat cattcatatt gacttctcct ttcaaattca taaggtaatt acgtagttta
     4141 attattttat attcttcact tttaattaca tccaacattt ctttttcttt attcattaaa
     4201 atattttcaa cttcttcagg attttctaca gcttttttta tctcagctaa tgataaaccc
     4261 atttgtttta aagttattat ctgatgtaat ttaggtaatt gctctgttgt ataataccta
     4321 tattttgtaa attcatctac atattctggt tttaacaacc ctatatcttc ataatacctt
     4381 aatgtctttg tagttatttt atttatttta gaaaacattc ctatagaaaa catctcatca
     4441 cctgcgcatt agatttgatt aatttaagtt taaactttcc ccttaggtta aagtcaatac
     4501 aaaataaatt ataattgtat taattcttca attctatctc cactcaatac caaaatatcc
     4561 cctgttttta taatggttga acctttaggt attaaaacct gttcctttct ttttatcata
     4621 actattaata tatcgtctgg tatattagaa tctattatac tcttattagc ccatttatta
     4681 ccctcatcaa catttacttc gataagttta gagctaattt ctccatcata atcattaaat
     4741 gtttttaata caggtgtatt atcatcaact aaatccaact ttctggctac agttggtatc
     4801 aatgaacctt gtattcctac tgaaagcaac gctataaaaa atattatatg gaatatgtca
     4861 ttctctatgg ctactccttg agtaacagca taaattgcaa aaactactga agccgcacct
     4921 ctaagaccta cccacgatat gaataatttt tctttatttg agaatttaaa ttttgctaga
     4981 actataaatg ttgctaatgg tcttgcaata actatcatga atatagatat ggccattgct
     5041 ataccaaata catttggtaa cttagaaggg aaagataaca atcctaacat aaagaataac
     5101 attatttgca taatccatga aattccatca aagaaatgaa ccaaactttt tttaagaggt
     5161 atcctactat ttcctataat aatacctgaa atgtaaacac ttaaatatcc atttcctcca
     5221 agatactcgc taaatgcata agaaagtatt gcaatagctg ttataaatat agtataaaat
     5281 ccttctatct cgaagtttga atgtcttaaa atataaacag ataattttgc tagtataaat
     5341 cctatagcta acccaaaagc tatttgtttt attaccattg gtgcaataag ttctacccca
     5401 gaattattca tcaatgtcaa aagaattagt gtcaacatat acgctattgg gtcattactt
     5461 ccactttcaa cttctaataa tgatgcaagt gaacccttta agtttagttt ttgagaacgc
     5521 aacacagcaa acacagatgc agcatctgtt gaagctgcaa ttgccccaat taataaacct
     5581 tcaagtaaac tagttcctat taccatgtgg caaaacatac ctgtaacgcc agccgtaatt
     5641 attacaccca gtgaagacat taatatagaa ggtatagcaa caggtttagc catattccag
     5701 tttgttccaa accctccaaa aaacattata aatattagtc caatagaaca taattgtttt
     5761 gtcagttcat agttatcaaa atagattcct accatcccat cagacccaaa taacatccct
     5821 agtaagataa aaatcaataa tattggtact ccaaatttat acaatacctt gctagaagtt
     5881 atacaaatca atagtactaa cccacttata atcattaatt ctgtcatagc atcaactcca
     5941 tttcatataa attttgtaga ttaatttaca tctacaattt tattacttat tcaaatataa
     6001 catgacataa attttataag ttatggtaca taaagttcaa caaaaatttc acaatacatt
     6061 aaaatgtgag tgttatactt aaatttat
//
LOCUS       DAEQCW010000157         6059 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.158, whole genome shotgun sequence.
ACCESSION   DAEQCW010000157 DAEQCW010000000
VERSION     DAEQCW010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6059)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6059)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6059
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.158"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(142..342)
                     /locus_tag="KRO40_003347"
     CDS             complement(142..342)
                     /locus_tag="KRO40_003347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000809131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH2094143.1"
                     /translation="MKNGIVKWFNNEKGFGFISVEGEDDVFVHFSAIQNDGYKTLEEG
                     EKVSFDITQGNRGPQAENVNRI"
     gene            809..2299
                     /locus_tag="KRO40_003348"
     CDS             809..2299
                     /locus_tag="KRO40_003348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2094144.1"
                     /translation="MFQFETQIHKLRHDVLTAIARLGKEDNLTREAMDNIQYEIIKGE
                     KPTYRCCVYKERAIISERVNVSMGLQPGQDKIDLDTMDIEEDEQIIYILEAACDSCPI
                     NEFTVTDICRGCLAHRCKEACKFGAITHVGGMAYINHELCKACGMCKKACQYDAISEV
                     VRPCKSVCPTNALGFDRENMKAMIHEDKCLNCGACMSACPFGAISDKSLIAPVARKLV
                     QKEKMYAVVAPAITGQVEANVTYGQIKNAIKSLGFVDVLEAACGADAVTVHESLEFAE
                     RMEKGEAFMTNSCCPGFVGYIEKTYPNHVGKISSTVSPMIASGRFIKSHEPDAKVVFI
                     GPCTAKKSEAAKKELKGAVDYVLTFEEIMALFEAFDIDLAKCSNEDIDDASIFGRGFG
                     AAGGLTKAIENYLAEKGIGVNFEPVKISGSREIKKTMTMANLGKLEGNFIEGMMCEGG
                     CINGSGKFLSGAKVKATFDRKNSQSTKKSVLANTKIKDFSNINLEK"
     gene            2579..4075
                     /locus_tag="KRO40_003349"
     CDS             2579..4075
                     /locus_tag="KRO40_003349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBH2094145.1"
                     /translation="MFEFETQLKRLKHEVLTAVARLSIEENLTKENIEKIPYEIIKGE
                     KARYRCCVYKEREVVLERAQLALSLTPNSKYGDINPDSVSLDTDEQIIYIVEAACDRC
                     PINEFTVTELCRGCLAHRCKEACKFGAISYINGRAYINHDLCKACGMCKSSCQYDAIS
                     EVVRPCKSVCPTGALDFNRNTMKAMIHEDNCINCGACMSACPFGAISDKSLIAPVAKK
                     LAKKENMYAIVAPAITGQIDSNITYGQLKNAIKSLGFVDMIEASCGADAVTVHESNEL
                     IERIKSGDNYMTNSCCPGFFKYIEKMFPDEKDRISSTVSPMVATGRLVKKIDSDAKVV
                     FIGPCTAKKSEATEKSLKDSVDYVLTFEELMALFEAFNIDLSKCSNEDINDGSIFGRG
                     FGASGGLAKSVQNYIAEKGLSFDFEPIKVSGPRQIKKTMTMAKLGRLEGNFIEGMMCE
                     EGCINGAGKFLSGVKAKNTFDRKNGQSTKKSVLSNDKIKEFEDVNLER"
     gene            4220..5146
                     /locus_tag="KRO40_003350"
     CDS             4220..5146
                     /locus_tag="KRO40_003350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBH2094146.1"
                     /translation="MRKIVLKDILFLVTTLSIIVILLLVTNITTNSKIKSTSESYLKS
                     DKNSVRQNGIQRSTKSSTKNTAFKTTILNTGKSDCILVEIGNKVIMIDTGEDKNGKQI
                     VDRLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDS
                     LKKADIEPVLLKDNMNIVINGAEINIHPASKSKYESSNDYSIITNISYGAHKFLFAGD
                     AEEERLSEFINGNTLKYDFVKMPHHGRYDKLTETFLESISPQYAVITCSEKKEPEEGV
                     LKILERLNIKTFLTSNGEVVINSDSKTLSVNQ"
     gene            5264..5455
                     /locus_tag="KRO40_003351"
     CDS             5264..5455
                     /locus_tag="KRO40_003351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094147.1"
                     /translation="MLDRFFGEGGFGGCAWWIIILFFLFLAFQDCWAEMDLCAWIPFL
                     ILLLILCECGDVFDGGCGC"
     gene            5678..6028
                     /locus_tag="KRO40_003352"
     CDS             5678..6028
                     /locus_tag="KRO40_003352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094148.1"
                     /translation="MAIVDKIFNEIKLMVARLLLGKKYSEYEEKDLVYNTEEEVILIT
                     LKRLVFQGNVNEAEEILFDKAKSVNSENMQYIAIEFYTMLMEKTDEELEAMNFSKQEV
                     YQGIEDIRKVLNLE"
BASE COUNT         2431 a          617 c         1088 g         1923 t
ORIGIN      
        1 gttattttaa aaaagttagt ttaagtttga cgcttttcta aagtaacttc ttatttttgt
       61 aattaaaaat aaatataata aacaacaaaa aagagccctc gatagctcct tttctaaaat
      121 atatatattt aaattaaata attatattct atttacgttt tcagcttgag gtcctctatt
      181 accttgagtt atatcaaagc taaccttttc gccttcttct aaagttttgt atccatcatt
      241 ttgtatagct gagaaatgta cgaaaacatc atcttctccc tctacagata tgaacccaaa
      301 tcctttttca ttgttaaacc attttactat tccgtttttc attataagaa aacctccgca
      361 ttattaaaaa atacaaacta aaaaaataag tctgttctat taatataaca taaattttaa
      421 ataaaagcaa ataaaatttt taaaaaaatt aattactttt agaatttaat aaaaattgtt
      481 aaattataca gtgataagta ttgtaaaatt tgacgaaaat gtaaatgtag ataataaatt
      541 taatatcaaa aaatgtaaca aaaaggtatg taagtaaaaa gtaaaattaa aatatataat
      601 aaaaaatatt atatattaga ttgaaaagta aaaataaaaa tagtgaaatt tcagaaatat
      661 caataatatt atataataaa acaaaaaaac actatatata ttcgataaaa taaaatttaa
      721 acatataata ttttatgtat atattaataa aaggacatat tgtgttataa tggtatcgta
      781 taaaatcatt tacgggggtg gtattaaaat gtttcaattt gaaacacaaa tacacaaatt
      841 aagacatgat gttttaactg caatagctag acttggaaaa gaagataacc ttaccagaga
      901 agcaatggat aatattcagt atgaaataat aaaaggtgag aaacctacat acagatgctg
      961 tgtttataaa gaaagagcta taatatctga gagagtaaat gtaagtatgg ggttacaacc
     1021 aggtcaagat aagatagatt tagatacaat ggatatagaa gaagatgaac aaattatata
     1081 tattttggaa gctgcatgtg acagttgtcc aataaatgaa tttacagtaa cagatatttg
     1141 tagaggatgt ctagcacata gatgtaaaga agcttgtaaa tttggagcta taacacatgt
     1201 cggaggaatg gcctatataa atcatgaatt atgtaaggct tgtggaatgt gtaaaaaagc
     1261 ttgtcaatat gatgccatct cagaggttgt tagaccatgt aagagtgttt gtccaactaa
     1321 tgccttagga tttgatagag aaaatatgaa agctatgata catgaggata aatgtttaaa
     1381 ctgtggagca tgtatgtcag catgtccatt tggagcaata tctgataaga gtttgatagc
     1441 tcctgtagct agaaagttag ttcaaaaaga gaaaatgtat gcggtggtag ctccagctat
     1501 aacaggtcaa gttgaagcaa atgttacata tggtcaaata aaaaatgcta taaaatcact
     1561 aggatttgtt gatgtattag aagcagcttg tggagcagat gcagttacag ttcatgaaag
     1621 cttagaattt gctgaaagaa tggaaaaggg agaagctttt atgacaaatt cttgttgtcc
     1681 aggatttgtt ggttatatag aaaaaacata cccaaatcat gtagggaaaa tatcttctac
     1741 agtatctcct atgatagcta gtggtagatt tataaaaagt catgaaccag atgctaaagt
     1801 tgtattcata ggaccatgta cagccaaaaa gagtgaggca gctaagaaag aattaaaagg
     1861 agctgttgat tatgtactta cttttgaaga aataatggca ttatttgagg catttgatat
     1921 agacttggct aagtgttcaa atgaagatat agatgatgca tcaatttttg gaagaggttt
     1981 tggagctgct ggtggtctta caaaagctat agaaaattat cttgctgaaa aaggtattgg
     2041 tgttaatttt gaacctgtaa agatttctgg ttcaagagaa atcaagaaaa ctatgactat
     2101 ggctaattta ggaaagctag aaggtaattt tatagaagga atgatgtgtg aaggtggttg
     2161 tataaatggt tctggtaaat tcttatcagg tgcaaaggtt aaagccactt ttgatagaaa
     2221 aaattctcaa tcaactaaga aaagtgtctt agcaaataca aagataaaag attttagtaa
     2281 tataaattta gaaaaataaa gataatacaa agcaacaaaa atacatattg ttaatagagt
     2341 tgttctaagt tgaggtttaa cttttggaca actctatttt tatttatata tttaattatt
     2401 gaacaactaa aataaaaatt atatacactt aaaataaaaa ttacatatat aatattttgt
     2461 atataactta acaaagtata tgcctatgtt ataataattt atagaaataa ataaaaaata
     2521 caatatacat aatagtagaa atatagcaaa aaggtgtgat ttatagggag gattacttat
     2581 gtttgaattt gaaacgcaac taaaaaggtt aaaacatgaa gttttaacag cagtagcaag
     2641 actatctatt gaagaaaatt taacaaaaga aaatatagaa aaaattccat atgaaataat
     2701 taaaggagaa aaggcgagat atagatgttg tgtttataaa gagagagaag tagttcttga
     2761 aagggcgcaa cttgcattaa gtttaactcc aaatagtaaa tatggagata taaatccaga
     2821 ttcagttagt ttggacacag atgagcaaat tatatatata gttgaagcag catgtgatag
     2881 atgtccaata aatgaattta cagttacaga gctttgtaga gggtgtttgg ctcatagatg
     2941 taaggaagca tgtaaatttg gggcaatttc ttatataaat gggagagcat atataaatca
     3001 tgatttatgt aaggcttgtg gaatgtgcaa aagttcatgt caatatgatg ctatatcaga
     3061 agttgtaaga ccttgtaaaa gcgtttgtcc aacaggggct ttggatttta atagaaacac
     3121 tatgaaagca atgatacatg aagataattg tataaattgt ggagcatgta tgtcagcatg
     3181 tccttttgga gcaatatctg ataagagttt gatagcacct gttgcaaaaa aacttgcaaa
     3241 gaaagaaaat atgtatgcaa tagtagctcc agctataaca ggtcaaatag atagtaatat
     3301 tacatatggt cagttaaaaa atgctataaa atcactggga tttgtagata tgatagaagc
     3361 ttcttgtgga gcagatgcag ttacagttca tgaaagcaat gaacttattg aaagaataaa
     3421 atcaggagat aattacatga caaattcatg ttgtccggga ttttttaagt atatagagaa
     3481 gatgttccca gatgaaaaag atagaatatc atctacagtg tctcctatgg tagcaacagg
     3541 aagattagta aaaaaaatag attctgatgc taaagttgta tttataggtc catgtacagc
     3601 taaaaagagt gaggcaacag agaaaagttt aaaagattca gtagattatg tacttacttt
     3661 tgaagaacta atggcattat ttgaagcatt taatatagat ttatcaaaat gttcaaatga
     3721 agatataaat gatggttcga tttttggaag gggatttgga gcatctggtg gacttgccaa
     3781 atcagtacag aactatattg ctgaaaaggg gcttagtttt gattttgaac ctataaaagt
     3841 atctggtcca agacaaatta aaaagacaat gacaatggct aaattgggaa gattagaagg
     3901 taattttata gaaggaatga tgtgtgaaga aggttgtatt aatggagcag gtaagttttt
     3961 atcaggtgta aaagctaaaa atacttttga tagaaaaaat ggacaatcta ctaaaaagag
     4021 tgttttatct aatgataaga ttaaagaatt tgaagatgta aatttagaaa gataattgtt
     4081 ttggtacagt cattttttta tcatgttttt atcatgccac aaatatgcct aaaatttgcc
     4141 ctttttatat gtgtatttta cagagttaag gttgctatac tataaatatg taataaataa
     4201 aatttatagg agcttttgga tgaggaaaat agtattaaaa gatatcctgt ttttagttac
     4261 tacattatct ataatagtaa tattattgct tgtaacaaat ataactacta atagtaagat
     4321 aaaatcaaca agtgaatctt atttaaaaag tgacaaaaat agtgtgaggc aaaatggtat
     4381 ccagaggagc acaaagagta gcacaaaaaa tactgcattt aagactacta tactaaacac
     4441 tggaaagtct gattgcatat tggttgagat aggtaacaaa gtcataatga ttgatacagg
     4501 agaagataaa aatggaaaac aaatagtgga taggttaaaa gaaaaaggaa taaatacact
     4561 tgactattta attttaactc atttagataa ggaccatata ggtggagtag atagtgtgtt
     4621 atctagtgtt aaagtaaaga atattataca agcaaattat aagaaagata gtaagcaata
     4681 tgatgaatat attgactcac ttaaaaaagc tgatatagaa ccagtgctac taaaagataa
     4741 tatgaatatt gtaatcaatg gtgcagaaat aaacatacat ccggcttcaa aaagcaagta
     4801 cgagagttca aatgattatt caataatcac taatataagc tatggagcac ataagttttt
     4861 atttgcagga gatgcagagg aagaaagatt gtcagagttt ataaatggaa atactttaaa
     4921 atatgatttt gttaaaatgc ctcatcatgg aagatatgac aaattaactg aaacattttt
     4981 agagtctatt tcaccccaat atgctgttat tacatgttca gagaaaaaag aaccagagga
     5041 aggtgtttta aaaatattgg aaagattgaa tataaaaaca tttttgactt ctaatggaga
     5101 ggtagttatc aatagtgata gtaagacatt gagtgtgaat caataatttt tttaaaaata
     5161 tctaaaaaaa tttaaaaaaa tcattagcaa atattacccc ttaaacatag tatattttag
     5221 gagctgaaac tccacataca aaatgactag gaggtaacat attatgttgg atagattttt
     5281 tggtgaaggc ggatttggtg gatgtgcttg gtggataata atattattct tcttattctt
     5341 agcattccaa gattgttggg ctgaaatgga cttatgtgca tggatacctt tcttaatatt
     5401 attattaata ctttgtgaat gtggtgacgt ttttgatgga ggatgtggat gctaaaaaaa
     5461 tcaatttaga tgatttaata aagcttatgg tgggtataaa taaaatacca aaccaatcac
     5521 aatctagtgt ttgaaggtag tcggaaatcc cccgctacct tctttttttt attgttaaaa
     5581 tttatttttg aattatttca tttacatata ataattttta cgataaagtc tgatataatt
     5641 aaaaagaaaa taaaatttat ttataggaga tgtaaaaatg gctatagtgg ataagatttt
     5701 caatgagata aaacttatgg ttgcaagact tttattggga aaaaaataca gtgaatatga
     5761 agaaaaagat ttagtgtata atacagaaga agaagttata cttataactt taaaaagatt
     5821 agtttttcag ggaaatgtaa acgaagcaga agaaatttta tttgataaag ctaagagtgt
     5881 aaatagtgaa aatatgcagt atatagcaat agaattttat actatgctta tggaaaaaac
     5941 tgatgaagaa ttagaagcta tgaatttttc taaacaagaa gtttatcaag gtatagaaga
     6001 tattagaaaa gtattgaatt tagaataaaa gatatatgaa aatattgaaa taaattaat
//
LOCUS       DAEQCW010000158         5984 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.159, whole genome shotgun sequence.
ACCESSION   DAEQCW010000158 DAEQCW010000000
VERSION     DAEQCW010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5984)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5984)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5984
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.159"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            785..1186
                     /locus_tag="KRO40_003353"
     CDS             785..1186
                     /locus_tag="KRO40_003353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNHCP domain-containing protein"
                     /protein_id="HBH2094149.1"
                     /translation="MNYKNRKRAYYQENSCMDNFICKNCGCLVVPEGAGTQHRNHCPH
                     CLHSLHVDIIPGDRAADCDANMEPIGVWVRKNGEWAIIHRCTRCGHLSSNRIAADDNS
                     VKLMSIALKPLAQPPFPLERIIEKLEKEETE"
     gene            1183..2250
                     /gene="rsgA"
                     /locus_tag="KRO40_003354"
     CDS             1183..2250
                     /gene="rsgA"
                     /locus_tag="KRO40_003354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBH2094150.1"
                     /translation="MNGMKQINLQDYGLNRNFITQSMEYYDLYLARIISQEKNFYQAV
                     CVNGVLFAEVSGKLRFEATIQSDFPTVGDFVMLDRCNNKNGNAIIHHVLHRKSLFVRK
                     AAGKVNEEQVVAANIDIVFLCMSLNKDFNIHRLERYLSLTWESGAIPVVVLTKSDLCD
                     NVHRKLQVVNSIALGVDVVVTSSIEPDGYKQISKYIKPGCTVALLGSSGVGKSSLINC
                     LMGGEFLNTKEIRIDDDKGRHATTRRELFLISGGGIVIDTPGMRELGMWDVSEGLDKS
                     FADIEAYFGKCHFRNCTHTSEPGCAIWEAIAHQELSPKRWESYRRLKAEAVFADNKSE
                     YLAKKEKKFKNISKINKTIRR"
     gene            2786..3472
                     /locus_tag="KRO40_003355"
     CDS             2786..3472
                     /locus_tag="KRO40_003355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094151.1"
                     /translation="MKISSQYRSQYSFRYESNINNTRINESMVKKNETVGKDTYLSNI
                     MKQKQELNDRIRDLKYRQEVYTKKINDAIKNLCKSEIRETTNNFSNIEIGIKNSIIED
                     KNKSTMLDENSTYLNTNDEKESLITKESNEKIEEEILNDEKLEELEQKKDSNKKEKVS
                     EDLSLVGKTREELENMLKNFINLTQEEIMKLESRIEKLDKNAEEYKQNSKTNIFDKTD
                     EQKKHINVLI"
     gene            3650..4540
                     /locus_tag="KRO40_003356"
     CDS             3650..4540
                     /locus_tag="KRO40_003356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094152.1"
                     /translation="MKKNILTTVITMIIILMMSMTVMAEPYQEDETSSLKKQSANERN
                     QTNIGTMDGRVQTNAISKGDNYDPKYPLKGMLTQLGLNTTGKEGWDLLYGGNPNGVEL
                     RADGKYYYINKGMEGLGFYAAALSGGSYQRIGFGKLDPIEVIADGNWISYKQAQDTLT
                     VIRNFLNSFDWRNASEMERANRAAKLVTEAKYADSKYCNIVYGNLVDKRGVCGSFASS
                     FHLLTRLMGMDSLSILNPSLNHAWNYIQIDGKWYRFDGSEISAFGGSLDFDYRKLKDA
                     TREMTTYYDAKALSILGFNQ"
     gene            complement(4942..5898)
                     /locus_tag="KRO40_003357"
     CDS             complement(4942..5898)
                     /locus_tag="KRO40_003357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBH2094153.1"
                     /translation="MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALI
                     GTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEWYSCTKVTDEAFIVYGTLWVIEK
                     DYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
                     AMANEFKLKSEKDLMTGLYNRHFFEVHIKKMLKTVSHGYFYIFDLDNFKQVNDIFGHV
                     RGDEILIHFSNILTKVFVNDAIIGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLES
                     NSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF"
BASE COUNT         2241 a          684 c          985 g         2074 t
ORIGIN      
        1 tacaataata caatagaatt gcttattatt caatatactt atttgaaaat taaataaatt
       61 tacaaatatg aacgttattt tatatcaaaa aaatagacta tgcatgtaga atatatggaa
      121 aaacttgatt gtaggttttg tatgaaaaga cagttgttat taatttaagt gagataaatt
      181 gagcaatagg cataaaatga gaaaacaaat aatagcagtt aatttttatt attaatacta
      241 ggtgaacatt aaattttaaa ataccactag attttataga ataagaaaat gagacaaaca
      301 taaatatatg aatatattaa attatacttg aacatactta tattttatga taaaatttca
      361 ataataatta ttagtgaagg agtgtcttgc ctgatgtcag agttatatat aatggtaacc
      421 aacaaataaa tagttggaga cgcatatggg ttctgtttaa tcagaatttt taagtgtatt
      481 tttgatacat ttgattgttg tgtcttactc tgcctttata gataactaac attagacaac
      541 aaataataat attacatatt actttgttaa attgtggtgt agtgggattt aatctgctac
      601 acttttatta attttacaca gtattatttt gaatataatt atgttgaaat agaagatatt
      661 aaattttcta gtccacaggg gttttctgtt tttgtgtagg taaatatgta taccacataa
      721 aaaggcagat ataaatacct gtggactttt tttgtagaaa atacaagata cggaggaaat
      781 aaaaatgaat tataaaaata gaaaacgagc ttattatcag gaaaattcct gtatggataa
      841 ctttatttgc aaaaattgtg gttgccttgt agttcctgaa ggagctggta cacaacatag
      901 aaatcattgc ccacattgtt tacatagtct tcatgtagat atcattcctg gtgaccgtgc
      961 tgcagattgt gatgctaata tggaacctat tggagtgtgg gtgagaaaaa atggtgagtg
     1021 ggcaattatt catcgttgta cacgctgtgg acatcttagt tctaatcgta ttgcagctga
     1081 tgataattca gtgaaattaa tgtcaattgc attaaaacca ctggcacagc cccctttccc
     1141 actagaaaga atcattgaaa agttggaaaa ggaggaaaca gaatgaatgg tatgaaacaa
     1201 atcaatttac aagactatgg tctaaatagg aattttatta ctcaaagtat ggaatattat
     1261 gatttatacc ttgctcggat tatctcgcag gaaaagaact tttatcaagc tgtatgtgta
     1321 aatggtgtac tgtttgcaga ggtttcagga aagctgcgtt ttgaggctac tatacaatct
     1381 gattttccca cagttggtga tttcgttatg ttggatcgtt gcaataataa aaatggtaat
     1441 gctattattc atcatgtgct tcatagaaaa agcttgtttg tgcgtaaggc tgctggaaag
     1501 gtaaatgagg agcaggtagt tgcagctaat attgacattg tttttttgtg catgtcactg
     1561 aataaggatt ttaacattca tagattggag aggtatctgt ctttaacatg ggaaagtgga
     1621 gctatcccag tagtagtact tactaaatca gacttatgtg acaatgtgca tcgtaaatta
     1681 caagtagtta attctatagc cttgggtgta gatgtagttg ttacctcatc tatagagcca
     1741 gatggttata aacagatttc taagtatatt aaaccaggct gtactgttgc cttacttggt
     1801 tcttcaggag ttggaaaatc ttcattaatt aattgtctga tgggtggaga atttttaaat
     1861 acaaaggaaa ttcgcataga tgatgataaa ggaagacatg ccacgactag acgagagcta
     1921 tttttaattt caggtggtgg tattgttatt gacacaccag gtatgagaga gttgggaatg
     1981 tgggatgttt cagaaggttt agataaaagt tttgcagata tagaagctta tttcggaaaa
     2041 tgtcattttc gtaattgtac tcacacctca gaaccaggct gtgctatctg ggaagctatt
     2101 gctcatcaag aactttcgcc taaaagatgg gagtcctatc gtaggcttaa agctgaagca
     2161 gtatttgcag acaataaaag cgaatactta gcaaaaaaag aaaagaaatt taaaaatatc
     2221 tcaaaaataa ataagacgat tagaagataa gtgtagtttt tttgttcatt ctatgagtct
     2281 atatactatt aatatattaa atttgccatc aatttgttac tttaatgtga ttttgatggc
     2341 aaatttggtt tgtggtatta tttaaagcaa tttattaatt tttttaataa agtttgattt
     2401 tttatatgat gatatataca tgtgataatg tatacatatt tgttacgata ggctccttta
     2461 taaagaggtc ttatgtaaga taagaaaagg catatttata ctaatacata atagagtata
     2521 tgcttatgta tgatagagat gtttcttaag agcaaaactg caatattgct aatttataaa
     2581 gtaaaaatat atgaattata aaatacaaat aatatattta taaaaattat tgttttaatt
     2641 tataataaaa attttttgtt gaaaataatg ctcgaaccta taaaactatt aactaatatt
     2701 tgtaaatgta tacttttgat gataaaatat aattaagtta agttggtttt tataaacata
     2761 aatttatttt aaggaggtga aataaatgaa aatatctagt caatatagaa gtcaatattc
     2821 atttagatat gaaagtaata taaataatac aagaataaat gaaagtatgg ttaagaaaaa
     2881 tgaaactgta ggaaaagaca cttatttatc taatattatg aaacaaaagc aagaacttaa
     2941 tgatagaatt agagatttaa aatatagaca agaggtttat actaaaaaaa taaatgacgc
     3001 aattaagaac ttatgtaaat cagaaataag agaaacaact aataactttt ctaatataga
     3061 aataggtatt aaaaatagca ttatagaaga taaaaataaa agtacaatgt tagatgaaaa
     3121 ttcaacttat ctaaatacaa atgatgaaaa agaatcttta atcactaaag agtctaatga
     3181 aaaaattgaa gaagaaatat taaatgatga aaaattagaa gagttagaac aaaaaaagga
     3241 ttctaataaa aaagagaaag tatctgagga cttatcttta gtaggtaaaa ctcgtgaaga
     3301 gcttgaaaat atgcttaaaa attttataaa tttaacacaa gaagaaataa tgaaacttga
     3361 gtcgagaata gaaaagttag ataaaaatgc tgaagaatac aaacaaaatt caaagactaa
     3421 tatatttgat aaaacagatg aacaaaaaaa acatataaat gtactgattt aaacaatatg
     3481 ttttaaaaaa ataagtttat tatataatga aaatataaag gtacaatttc aatacacttc
     3541 tattaaacca ataatttatg aatcagactt aatttcaatt tactaataac catatattta
     3601 tgagttaata attttatgtt ttaaaaagaa ttaaataagg gggagtagta tgaagaagaa
     3661 tatattaact actgtgatta ccatgattat tatattgatg atgagtatga cggtaatggc
     3721 agagccatat caagaagatg aaacatctag cttgaaaaaa cagagtgcaa atgaacgtaa
     3781 tcagactaat ataggcacaa tggatggcag agtgcaaaca aatgcaataa gtaaaggtga
     3841 taattatgac cctaaatatc ctcttaaagg aatgttaaca caacttggtc ttaatacaac
     3901 aggtaaagag ggatgggatt tactctatgg aggaaatccc aatggagttg agcttcgagc
     3961 agatggtaaa tattattata taaataaggg tatggaaggg ctaggatttt atgcggcagc
     4021 attgtcaggt ggctcatatc agagaatagg ctttggaaaa cttgacccta tagaagtaat
     4081 agctgatgga aattggattt cttacaaaca agctcaagat acacttacag taataaggaa
     4141 ttttttaaat agttttgact ggagaaatgc atctgagatg gaaagagcta atagagctgc
     4201 aaaattggta accgaagcaa aatatgcaga ctctaaatat tgtaacatag tctatggtaa
     4261 tctggttgat aaacgtggtg tatgtggaag ttttgcaagt agctttcatt tattaacaag
     4321 gttaatggga atggattcac tatctatatt aaatccatca ttaaatcatg cttggaacta
     4381 tatacaaatt gatgggaaat ggtataggtt tgatgggtct gaaatatcag cttttggtgg
     4441 atcattagac tttgattacc gtaaattaaa ggatgcaaca agagagatga ctacttacta
     4501 tgatgcaaag gcattgtcta tattaggatt taatcaataa aaataggggg aggcttctta
     4561 tagagccttt ttttattgat ttgaaattta ataaggaatt ttatatgaaa atttaatcaa
     4621 taaaagcaaa aaaggctctt tataaagcct ttctaagtgt ttttttaagt aaaatttttt
     4681 atatcaacat cagttttaat caaaacatat aacattttgg acttactttt aaaaataaaa
     4741 ttattaaaat ataatattaa tcatgttaat aatgttttta gtttattata ttctataata
     4801 gtggtcatgt tgactattgt agttttatta agaatagttg gtttatataa atatatgcaa
     4861 agatagcttg ttgtttactt tacttattag tatataggac aagatactct aataaatttg
     4921 cctattttaa tatcttttgt actaaaacca actaaagttt cctttattat ttcgttttga
     4981 ataatacaaa gcataatccg attgtttgta taaagactgg aaagtatcag agttattttc
     5041 taatttagat atacctatag aacaagaatt actctctagg cataattcta aaaccttctt
     5101 tgccttattt tcaacattct cttttgattg attactatat tcaaaaacag caaattcatc
     5161 tccaccaagt cttccaataa tagcatcatt tacgaatact ttagtcaaaa tatttgaaaa
     5221 atgtattagt atttcatctc ctcgaacatg accaaagata tcatttacct gtttaaaatt
     5281 atctaaatca aagatgtaaa agtatccatg tgaaacagtt ttaagcattt tttttatgtg
     5341 tacttcaaaa aaatgtctat tgtatagtcc agtcataagg tctttttctg attttagttt
     5401 aaattcattt gccattgcta gtgcttcttg tgctttttca gttattgttt tagggtaata
     5461 ctcatctttc atttggtcaa agtttggaat agaatggtga acatggataa gtttaatcat
     5521 atcatctgta actctgtata ccatagtaaa tcgagtatcc atttctacat agatatcttt
     5581 ttctaggtaa tctttttcta ttacccaaag agtaccatat actataaaag cttcgtctgt
     5641 gactttggta catgaatacc actcatctat aatctcaaag tctatttgct ctgattctgt
     5701 ttggtctttt tcaagaccta taataaattc ttctaatgtt tcgtaaaatt catgttttcc
     5761 tgttccaatt aatgcaaggt tgtcatctaa taaggaaata ataaatttaa ggttttcttc
     5821 ttctggattt aaaatataaa tatgccaaat tttttttgat aaatctctta attgtttttg
     5881 tattgtatta ttttccatag attaccccct taagatttac agtttatatt ttaatgtatt
     5941 ataagttgaa ctcttattac aatattatta taatatagaa ctaa
//
LOCUS       DAEQCW010000159         5966 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.160, whole genome shotgun sequence.
ACCESSION   DAEQCW010000159 DAEQCW010000000
VERSION     DAEQCW010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5966)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5966)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5966
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.160"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            101..667
                     /locus_tag="KRO40_003358"
     CDS             101..667
                     /locus_tag="KRO40_003358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2094154.1"
                     /translation="MSVSLQKGQRVSLVKDNNPVKNLVVGLGWDMNKLGKKNYDLDAF
                     AIALTNQDKMNVRGDLVYFGNLKHPSKAIIHTGDNLTGKGEGDDEQIIVNLEDIPEYV
                     HKIVFGVSIYKAKKRDQDFGQMNNSFIRLIDSNSKQELFKYNLQEDFSGKVTVLAGEI
                     YRRNEEWKFNALGIGQNEELRELINTYK"
     gene            707..1288
                     /locus_tag="KRO40_003359"
     CDS             707..1288
                     /locus_tag="KRO40_003359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBH2094155.1"
                     /translation="MGITLAKGQKVSLTKSNPGLKKVIVGLGWDINKYDGGFDFDLDA
                     SAFLTGTDGKVTNDGDFIFYNNLKHASGAVEYMGDNRTGVGDGDDEQINVDLSKIPQN
                     IAKISFSVTINEAITRRQNFGQVENSYIRIYNEETNEELIKYELGEDFSIETAIVVAE
                     LYRHNGEWKFNALGSGFEDGLAGLCKNFGVNIG"
     gene            complement(1345..2262)
                     /locus_tag="KRO40_003360"
     CDS             complement(1345..2262)
                     /locus_tag="KRO40_003360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBH2094156.1"
                     /translation="MTIRSLEIFVKVAECGKMSEVARNMYITQSSVSQAISEIEKEYG
                     VKLFDRISKKLYLTEAGKKLLGYGRHLLAVNEEMNDCMKHCAKNIRIRVGATVTVGTC
                     VISPIMLELYKVNPLIEPEVFVEDTRLIAKKLLNSELDIAIVEGKIKHPDIVTKSIIN
                     DNLVLICSHKHEFYKRDSIKVSELSNQPLIMRELGSGTRAQLEKQLKELKIPMNIRWS
                     CYNSEAILRAVVDNFGIAVISELLIEDYLKKHLLWACDIEGINLHRTFDIAYHRSKFF
                     TENISAFFDISVEYGKKQARKKSRSVNSL"
     gene            2392..4023
                     /locus_tag="KRO40_003361"
     CDS             2392..4023
                     /locus_tag="KRO40_003361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH2094157.1"
                     /translation="MKVLIIGGVAAGTKTAAKIKREMGDNCSVTILNKGDDISYAGCG
                     LPYYVGKIIEDKSSLIVNTPESFSKLTGAEVRCGVEVTSIDRNAKQVTLKTLSTGEKE
                     NLSYDKLVIATGADPIKPPIPGIDLPGVFFMRTPNDAIKLRDSIENGIKRAVVIGGGF
                     IGLEIAENLSAMGIRVSVVDMAEHVMPGFDTDFAEYVENHMADKGIMIFTGDQVVGIE
                     GENKVEKLRTKNRAIKTDLVVMSVGIRPNTGFLKDTGLEFAPNNTIIADEYMLTNDKD
                     IYVVGDCAFVKNSLTNKPTWSPMGSSANHEGRICAQNISGKSKTYNGVLGTTVVKLPE
                     LNAGKTGLSKEIAEKEGYNVCSVTIATDDKAHYYPGASNFIIRMVAEKNTRKLLGVQV
                     MGPGAVDKIVDIAATAITLGADLYSLESMDLAYAPPFSTAIHPFVVAVNVLQNKLNGE
                     LDSVLLDEIEDFDSWTKLDVSKAPSIPSLRYIPVGEINGEIEGLAKDEKILLICAKGK
                     NSYMAQNRLRRFGYTNTKVLEGGILFYPNLKVMEE"
     gene            4026..4973
                     /locus_tag="KRO40_003362"
     CDS             4026..4973
                     /locus_tag="KRO40_003362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013378669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="HBH2094158.1"
                     /translation="MSNVTAEQKKEVKGRGFLPSRDGEHFAARIITVNGVINASQAKK
                     IAEAAEKFGNGQLAFTTRLTVELPGVKFEDIEALSEFIASENLITGGTGSRVRPVVAC
                     KGTVCVHGLADTQALAAEIHEEFYKNWYDVKLPHKFKIGVGGCPNNCIKPDLNDLGIV
                     GQRVPDYDSELCVGCKKCAVVEVCPVKAAKLTDKGKLEIDSNLCNNCGKCIESCNFDS
                     IEEKESGYKVYIGGKWGKSVRPGTQIDRLFSKEELMTLIEKAILLFREQGNTGERFGI
                     TIDRIGADKFIEMLLSDEVLERKEEILEALLHLTGGAVC"
     gene            complement(5258..5521)
                     /locus_tag="KRO40_003363"
     CDS             complement(5258..5521)
                     /locus_tag="KRO40_003363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1883 domain-containing protein"
                     /protein_id="HBH2094159.1"
                     /translation="MEYSYSKMNLKKGDIVEVNLEKQANVILLDHINYVKFKNQRNYD
                     YYGGFAKKNPCRMRVPNTGTWYLVVNQDGNSGIVNFSINTIQN"
     gene            complement(5620..5865)
                     /locus_tag="KRO40_003364"
     CDS             complement(5620..5865)
                     /locus_tag="KRO40_003364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094160.1"
                     /translation="MFIDEELEGYILTCKISEDFKNIPEYSDEEFYVTVYKDESSDSG
                     YYALLENKEERVVWDGEVVANNIFNNLWIVINKVKTG"
BASE COUNT         2145 a          818 c          980 g         2023 t
ORIGIN      
        1 atatagccaa cttagcctaa atacgtatat aatatagcta atatggttct tatacttgat
       61 accatcaata aaactaaaaa tataaaaagg agaacttaaa atgagtgtta gtttacaaaa
      121 aggacaaaga gttagcttag taaaagataa taatcctgta aaaaatctag tagtaggctt
      181 aggatgggat atgaataaat tgggtaaaaa aaattatgac ctagatgcat ttgcaatagc
      241 attgactaac caagataaaa tgaatgttag aggtgacttg gtttattttg gaaatcttaa
      301 acacccttct aaagctatta tacacactgg agataactta actggaaaag gtgaaggtga
      361 tgatgaacaa ataattgtta atttagaaga catacctgaa tatgtacata aaatagtttt
      421 tggagtttct atatacaaag ctaaaaaaag agaccaggat tttggtcaaa tgaacaactc
      481 ttttataaga ttaattgatt caaattccaa gcaagaatta tttaaatata atcttcaaga
      541 agacttttct ggtaaagtaa cagttttggc aggagaaatt tatcgtagaa atgaagaatg
      601 gaaatttaat gctttaggaa ttggtcaaaa tgaagagctt cgtgaattaa ttaatacata
      661 taagtaataa ttacaataaa aaatttataa tgaggagttg gtttaaatgg gtataacttt
      721 agcaaaagga caaaaagtaa gtttaacaaa aagtaaccct ggtctaaaaa aagtaatagt
      781 aggactagga tgggatatta ataaatatga tggtggcttt gatttcgatt tagatgcctc
      841 tgcattttta actggaactg atggaaaagt aacgaatgat ggagacttta tattctataa
      901 taatttaaaa cacgcttctg gagctgttga atatatgggt gataatagaa caggtgttgg
      961 tgatggtgat gatgaacaaa taaatgtaga cttatctaaa atacctcaaa atattgctaa
     1021 aatatcattt agtgttacta taaacgaagc aattacaaga agacaaaatt tcggacaagt
     1081 tgaaaattca tatataagaa tatataatga agaaactaat gaggaactta ttaaatatga
     1141 attgggtgaa gattttagca tagaaacagc aatagttgtg gcagaactat atagacataa
     1201 tggagaatgg aaatttaatg ctttaggttc tggatttgag gatggacttg caggattgtg
     1261 taaaaatttt ggcgttaata taggctaata tatctaaata aaaataagag tatattgata
     1321 tactcttatt tttatttaga tatattataa actgtttaca cttctactct tctttctcgc
     1381 ttgttttttc ccatattcta ctgaaatatc aaaaaatgct gaaatatttt ctgtaaaaaa
     1441 cttgcttcta tgatatgcaa tatcaaatgt cctatgtaaa ttaatacctt caatatcaca
     1501 agcccacaaa agatgctttt ttaaataatc ctcaataagt aattcggata taactgcaat
     1561 gccaaaatta tctacaactg ctcttaatat agcttcagag ttataacatg accatctaat
     1621 attcattggg atttttaatt cttttaattg cttttctaat tgtgctcttg taccacttcc
     1681 taattcacgc ataattaatg gttgatttga aagttctgaa acttttatag agtctctttt
     1741 ataaaactca tgcttgtgtg aacatataag tacaagatta tcattaataa tgctttttgt
     1801 aacaatatct gggtgcttaa tttttccttc tacaatcgca atatctaatt cactattaag
     1861 taattttttt gcaatcagtc ttgtatcttc tacaaatact tcaggttcta taagaggatt
     1921 taccttgtat aattctaaca ttattggact tattacacat gtaccaacag ttactgttgc
     1981 cccaactctt atacggatat tttttgcaca atgcttcata caatcattca tttcttcatt
     2041 tacagctaaa agatgcctcc catatccaag aagttttttc cctgcctcag ttaaatataa
     2101 tttttttgaa attctatcaa atagcttaac accatactct ttttctattt ctgaaatagc
     2161 ttggctaact gatgactggg taatatacat atttcttgct acttcactca ttttaccaca
     2221 ttcagcaacc ttaacaaaga tttcaagact acgaattgtc atattatcac aaccttagca
     2281 aacattagta aatgcttatg attttattaa tattttagta ttttacaaat atattgtcaa
     2341 gaagtataat tttattatag agttataaag tagattggag tgtgatatat tgtgaaagta
     2401 ttaattatag gtggagttgc tgctggaaca aaaactgctg caaaaataaa acgtgaaatg
     2461 ggtgataatt gctctgttac aatactaaat aaaggtgatg atatttctta tgcaggttgt
     2521 ggtcttccat attacgttgg taagataatt gaagataaat catctttaat cgtaaataca
     2581 cctgaaagtt tttctaaact aacaggagca gaagttcgtt gtggagttga agttacatct
     2641 attgatagaa atgcaaaaca agtaactttg aaaacgcttt caacaggaga aaaagaaaat
     2701 ctaagctatg acaaacttgt aattgctaca ggggcagacc caataaaacc accaatacct
     2761 ggaatagatt tacctggagt attctttatg cgtactccaa atgatgctat aaaactaaga
     2821 gattctattg aaaacggtat taagagagct gttgttattg gtggaggttt cattggtctt
     2881 gaaattgctg aaaatctttc tgcaatgggt atacgtgtaa gtgttgttga tatggctgaa
     2941 catgttatgc ctggatttga tactgatttt gctgaatacg ttgaaaatca tatggctgat
     3001 aaaggcataa tgatttttac aggtgaccag gttgtaggta tcgaaggtga aaataaagtt
     3061 gaaaaacttc gtactaaaaa tagagctatt aaaacagatt tagtggttat gtcagttgga
     3121 atccgtccta acacaggttt tctaaaagac acaggtttag aatttgcccc taataataca
     3181 attattgcag atgaatatat gcttacaaat gacaaagata tatacgtagt tggagactgt
     3241 gcttttgtaa aaaattcttt aacaaataaa cctacatggt cacctatggg gtcatctgca
     3301 aatcatgagg gtagaatttg cgcacaaaat atatctggaa aatctaaaac ttacaatggt
     3361 gttcttggaa caacagtagt aaaattacct gagctcaatg caggaaaaac aggtctaagt
     3421 aaagaaatag ctgaaaaaga aggttataat gtttgctctg taaccatagc tactgatgat
     3481 aaagctcatt attatccagg tgcatctaat tttattataa gaatggttgc tgaaaaaaat
     3541 actagaaaat tattaggtgt tcaagttatg ggacctggag cggttgataa aatagtagat
     3601 atcgctgcta ctgcaataac tttaggcgct gacctttatt cattagaaag tatggacctt
     3661 gcatatgcac cacctttttc aacagctatt cacccttttg tagtggcagt aaatgtttta
     3721 caaaataaac ttaatggaga acttgatagt gttttacttg acgaaattga ggattttgac
     3781 agttggacta aacttgatgt ttcaaaagct ccttctattc ctagtttacg ttatattcct
     3841 gttggtgaaa ttaatggaga aattgaaggc cttgctaagg atgaaaaaat tcttcttata
     3901 tgtgctaaag gtaaaaatag ctatatggcg caaaatcgct taagacgctt tggctataca
     3961 aatacgaaag ttcttgaagg tggaatacta ttttatccaa atcttaaggt aatggaggag
     4021 taaatatgag taatgttaca gcagaacaaa aaaaggaagt aaaaggtaga ggttttctac
     4081 caagcaggga tggagaacat tttgcagcac gtataataac tgtaaatggt gtaataaatg
     4141 catcacaagc aaaaaaaatt gcagaagctg ctgaaaaatt cggaaacggt cagttagcat
     4201 ttactactag actaacagta gaattacctg gtgtaaaatt tgaagatatt gaagctctaa
     4261 gtgaatttat tgctagcgaa aatctaataa caggtggaac tggatcaagg gttcgtcctg
     4321 ttgtggcttg taaaggtact gtttgtgttc atggtctagc tgatacacag gcacttgctg
     4381 ctgaaataca cgaagaattt tacaaaaatt ggtatgatgt aaaactacct cataagttca
     4441 aaattggtgt tggtggatgc cctaataact gtattaaacc tgacctaaac gatcttggaa
     4501 ttgttggtca acgtgtacct gactatgatt cagagctttg tgttggttgt aaaaaatgtg
     4561 ctgttgtaga ggtctgtcct gttaaagcag ctaaattaac agataaaggt aaacttgaaa
     4621 tagatagtaa tctatgtaat aactgtggta agtgtataga aagttgtaat tttgatagta
     4681 ttgaagaaaa agaatctggt tataaagtct atataggagg gaaatgggga aaatcagttc
     4741 gtcctggaac acagattgat agattatttt caaaagagga acttatgact ttaattgaaa
     4801 aagcaattct tttatttaga gaacagggta acacaggtga acgttttgga ataactatcg
     4861 atagaatcgg tgctgataaa tttatagaaa tgcttttatc agatgaagtt ttggaaagaa
     4921 aagaagagat actagaggct cttttacacc ttacaggtgg agctgtatgc taacaataaa
     4981 tattttaatt gtacagataa cctatggaaa aaattttagt taagaataat taaaattcta
     5041 tatatgatat atgataaatg aggctatctc aaaacacaga tacgcctctt tttcattgtt
     5101 gaaatgataa agtatatttg agttcatata aaaaagagtg tctcgtgaat tataaaattc
     5161 attttgaggc acccacatta ttttataata attgcttatt aattttattt taactatata
     5221 aaaagtacaa aaagtaagaa tatccaatat tctaaaatta attttgaatt gtattgattg
     5281 aaaagtttac tattccacta tttccatctt gatttactac tagataccat gttccagtat
     5341 taggaactct cattctacat ggatttttct ttgcaaatcc accatagtaa tcataatttc
     5401 tttgattttt aaatttcaca taatttatat ggtctaacaa tattacattg gcttgtttct
     5461 ctaaatttac ctctacaata tccccttttt ttaagttcat cttactataa ctatattcca
     5521 ttgaattact cctccagtat cgaataatct ttgttattta ctcatctcaa atatgtaaaa
     5581 attcatttaa aatattacaa atactatata attagactat tatccagttt taaccttatt
     5641 tattacaatc caaaggttat taaaaatatt attggcaaca acttctccat cccatacaac
     5701 tctttcttct ttattttcta ataaagcata gtacccagag tcagaacttt catctttata
     5761 gactgtaaca taaaactctt catcactata ttcaggtata tttttaaagt cttcagatat
     5821 tttacatgtt aatatataac cttctaattc ttcatctata aacaaagcaa ttcctccaat
     5881 ctctatattt ttactaatta taccatatta tgtcataaac tttttatttt attacaaatt
     5941 tctatttttt ctttacttta taaata
//
LOCUS       DAEQCW010000160         5818 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.161, whole genome shotgun sequence.
ACCESSION   DAEQCW010000160 DAEQCW010000000
VERSION     DAEQCW010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5818)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5818)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5818
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.161"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(312..2144)
                     /locus_tag="KRO40_003365"
     CDS             complement(312..2144)
                     /locus_tag="KRO40_003365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094161.1"
                     /translation="MSRMGRGPMGKSMGAGQKANDFKGTMRKLIAYLSKFKISIILVI
                     VFAIGSASFSIVGPKILGKATTKIFEGLVSKVSGGNVGIDFNAIGKILTFLLFLYLIS
                     ALFSFIQGFIMSGISQKVSYNLRKEISAKLDRLPMKYFDTKTHGEILSRITNDIDTLN
                     QSLNQSMTQLITSVTTMIGVLIMMLSISGIMTLVAVLILPISMFVISRIIKKSQKYFR
                     YQQEYLGNVNGQVEETYSGQTIVKAFNREDEVIEEFDKLNDSLYNSAWKSQFLSGIMQ
                     PLMMFIGNLGYVMVSILGGWLAIKKTIEVGDIQSFIQYVRNFTQPMTQIAQVANLLQS
                     TAAASERVFEFLEEEEEVQIVENAVSIDGLEGKIDFENVNFGYNPNKTIINDFSVNVK
                     PGQKVAIVGPTGAGKTTIVKLLMRFYDVNSGSILIDGHNIKDFNRSELREMFGMVLQD
                     TWLFSGSIMENIRYGKLNATDEEVIEAAKSAHVHRFIKTLPDGYKMKLNEEASNVSQG
                     QKQLLTIARAILADPKILILDEATSSVDTRTEVLIQKAMDNLMEGRTSFVIAHRLSTI
                     RDADMILVMNEGDIVEQGNHEELLKKGGFYANLYNSQFEEDEAM"
     gene            complement(2137..4383)
                     /locus_tag="KRO40_003366"
     CDS             complement(2137..4383)
                     /locus_tag="KRO40_003366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011009877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094162.1"
                     /translation="MFKLIKYLKKSALSIVIIVCLLVIQAVCDLSLPEYTSNIVNVGI
                     QQGGVENSVPSVIRESELNKITLFMDKSSKDKVLDNYTLLNKKDYVKYKDKYPGLKDE
                     SLYELNTKDKDTIDDLNVIFGKAILIVSGLEGDSKEVKAMKAQLMSKLPPQATQSGDV
                     DIFKLLSAMPKEQLDTLTKEMSKGFESMPESMITQSSVSYVRSEYEKIGIDTEKTQNN
                     YILFTGAKMLGIAMISMVATITVGFLAARVAASVGRNLRSGVFRKVMSFSNTEMNEFS
                     TASLITRSTNDIQQIQMLMVMLLRIVFYAPIMAIGGVIKVLNTNTSMAWIIAVAVVAI
                     LSLIVVLFSVVMPKFKLVQKLVDKLNLVSREIITGIPVIRAFSTEKHEEERFDKANKN
                     LTKTNLFVNRVMTCMMPAMMLIMNLITVLIVWRGAYSVDSGAMQVGDMMAFIQYTMQI
                     IMSFLMISMVSIMLPRASVSATRIDEVLVSDISIKDPEKSEAQEFKEDKKGLVEFKNV
                     SFMYPDAEEPILTNISFTAKPGETTAFIGSTGSGKSTLINLIPRFFDVTEGEILLGGV
                     NIKNVSQHDLREKIGYVPQKGVLFSGTIESNLKYGRKDATDEEMRTAAEIAQATEFID
                     SKPEAFKTEISQGGTNVSGGQKQRLSIARAIAKNPEVYIFDDSFSALDLKTDAALRKA
                     LKSKTAESTVLIVAQRISTILNAEQIIVLNEGEIVGIGTHKELLKNCEVYEQIALSQL
                     SKEELANE"
     gene            complement(4451..4912)
                     /locus_tag="KRO40_003367"
     CDS             complement(4451..4912)
                     /locus_tag="KRO40_003367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2094163.1"
                     /translation="MNSNSEEKLNDVFLQLMRIYFIRTHFYFDKLGLYHGQPQILFSL
                     KMKDGQSQKELADKRKVKASTTTVMIKRMEKAGLVERKQDEKDQRVSRIFLTDKGLEI
                     CNKVEEFNKELEREFFLGFSEEEKIVLRRLLMQVRDNLKAGCHKHEDEKYF"
     gene            complement(5217..5783)
                     /locus_tag="KRO40_003368"
     CDS             complement(5217..5783)
                     /locus_tag="KRO40_003368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HBH2094164.1"
                     /translation="MRKLEEILEYNKSFVENKEYEQYVTSKHPNKKIVVLSCMDTRLT
                     ELLPKAMNLKNGDVKLIKNAGATIMHPFGSIMRSVLVAIYEFDVDEVMVVGHHGCGMC
                     NVDTDKLLGKILDRGISNDVILTLRSAGIDTKQWLHGFDSAEESVKDSIDLIKGHPLI
                     PDGIIVHGLIISPETGKLDVVVNGYEDK"
BASE COUNT         1860 a         1082 c          632 g         2244 t
ORIGIN      
        1 atataatcat caactattaa aattaaattc tatttataat aaaatttaaa gaataaaatt
       61 aaatatacat tttgataatc acctccaaca ttttccttac tacatattat aataaaataa
      121 acactttgta aagacataaa attatgtggc tatctcaaaa tatagagaat cctctttttc
      181 attgttaaaa tgataaaaat acactttatt tcatacacaa aagagtgcct tatgaattaa
      241 aaagttcatt ttaaggcacc ctcatttatt ttatcttatt aattacatgt ctatgctaag
      301 atagtttttt gttacattgc ttcatcttct tcaaattgag aattgtaaag attggcatag
      361 aatccgcctt tctttagaag ttcctcatga tttccttgtt caactatatc tccttcattc
      421 attacaagaa tcatatcagc atcacgtata gttgataatc tgtgggctat aacaaaactt
      481 gttctacctt ccataagatt atccatagct ttttgaatca atacttctgt tctagtatcg
      541 acagaacttg tagcttcatc taatattaaa attttaggat cagctaaaat agcacgagct
      601 atagtcaata attgtttttg accttgagaa acattacttg cttcttcatt taatttcatc
      661 ttatatccat ctggtaatgt cttaataaat ctatgaacat gtgcagattt agcagcctct
      721 ataacttctt catctgtagc attcaactta ccatatctta tattttccat aattgaacca
      781 ctaaataacc atgtatcttg aagaaccata ccaaacattt ctctaagctc actacgatta
      841 aaatctttaa tattatgacc atcaatcagt attgaaccgc tattaacatc ataaaatctc
      901 attaacagtt taactattgt agttttacct gctcctgtag gtccaacaat agcaactttt
      961 tgaccaggtt taacatttac tgagaaatca tttattatag tcttgtttgg gttatatcca
     1021 aagttgacat tttcaaaatc aattttacct tctaaaccat ctattgaaac tgcattttca
     1081 acaatttgga cttcttcttc ctcttctaaa aactcaaata ctctttcaga agctgctgct
     1141 gttgattgca ataaattggc aacctgtgca atctgagtca ttggctgtgt aaagtttctt
     1201 acatattgta taaatgactg tatgtcacca acctcaattg ttttcttaat tgcaagccaa
     1261 cctcctaaga ttgataccat tacatatccc aagtttccaa taaacatcat aagtggttgc
     1321 attatacctg ataaaaattg agatttccac gctgaattat acaggctatc atttagttta
     1381 tcaaactctt caattacttc atcctcacga ttaaatgctt ttactattgt ttggccactg
     1441 taagtttcct caacttgacc atttacattt cctaaatatt cttgttgata tctaaagtat
     1501 ttttgtgatt tctttattat tcttgaaatt acaaacattg atattggtaa tattaaaact
     1561 gccactaatg tcataattcc acttatagat aacatcatta tcaaaacacc tatcatagtt
     1621 gttactgatg ttataagctg tgtcatactt tgatttaaac tttgatttaa agtatctata
     1681 tcattcgtaa ttctcgataa tatttcacca tgcgtcttag tatcaaaata cttcattggc
     1741 aatctatcca attttgctga aatctctttt cttaaattat aggatacttt ttgagaaatt
     1801 ccactcatta taaatccttg tataaaagag aacagtgcac ttatcaaata aaggaaaagt
     1861 aaaaaggtta agatttttcc aattgcatta aaatctatac ctacgtttcc tccagaaact
     1921 ttactcacta gcccttcaaa tatctttgta gttgcctttc ctaaaatttt tggacctact
     1981 atagaaaacg acgcactacc aatagcaaat acaattacta gaattattga tattttaaat
     2041 ttagataaat atgcaattag ttttcgcata gtccctttaa agtcatttgc tttttgtcct
     2101 gctcccatag attttcccat aggacctctt cccattctac tcattagcta gctcctcctt
     2161 tgaaagttgt gataaagcta tttgctcata aacttcgcaa ttttttagaa gctctttatg
     2221 tgttcctatt ccaactattt cgccctcatt taaaacaatt atctgttctg catttaagat
     2281 agtactaatt ctttgtgcaa ctattagaac tgtactttca gcagtttttg attttaaagc
     2341 cttacgaaga gctgcatcag tttttaagtc aagtgctgaa aaactatcat caaatatata
     2401 aacttctgga ttttttgcta ttgctcttgc aatagaaagt ctttgttttt gacctccaga
     2461 tacatttgtt ccaccttgag aaatttcagt tttaaaagct tccggtttag aatctataaa
     2521 ttctgtagct tgagctattt cagctgctgt tctcatttct tcatctgttg cgtcttttct
     2581 accatatttt aagttggatt ctatagtacc agaaaacaat actccctttt gaggtacata
     2641 tccaattttt tcccttaaat catgttgaga aacatttttt atattaactc caccaagtaa
     2701 tatttctcct tcagtaacat caaagaaacg aggaattaaa tttataagag ttgacttacc
     2761 actaccagta cttcctataa aggcagttgt ttctcctggc tttgctgtaa aagatatatt
     2821 tgttaatata ggttcttctg cgtctggata catgaacgaa acatttttaa attcaacaag
     2881 acccttttta tcttccttaa actcttgtgc ctctgatttt tctgggtctt ttatgcttat
     2941 atctgacact aatacttcat ctatacgtgt agctgaaacg gatgctcttg gaagcataat
     3001 agataccatt gatatcatta agaatgacat tattatttgc attgtatatt gtataaatgc
     3061 catcatatct ccaacttgca ttgctccaga atcaacactg tatgcacctc tccaaactat
     3121 aagaactgtg ataaggttca ttataagcat catagcaggc atcatacatg tcataactct
     3181 atttacaaaa agatttgttt tagttaaatt tttatttgct ttatcaaatc tttcttcttc
     3241 atgtttttca gtactaaaag ctctgataac tggaatacca gtaattattt cacggcttac
     3301 taagtttaac ttatcaacaa gcttttgaac cagtttaaac ttaggcataa ccactgagaa
     3361 taacactaca attaatgata agatagcaac tactgctact gctataatcc aggccattga
     3421 agtatttgtg tttaaaacct ttatcactcc acctatagcc attataggtg catagaatac
     3481 tattctaagc aacataacca tcaacatttg tatctgttga atatcatttg tactacgagt
     3541 aattaatgaa gctgtagaaa attcattcat ttcagtattt gaaaatgaca taacttttct
     3601 aaatactcca cttcttaaat ttctacctac acttgctgct actcttgctg ctaaaaatcc
     3661 tactgttatt gtagctacca tactaatcat tgctatacca agcattttag caccagtaaa
     3721 taatatataa ttattttgag ttttttctgt atcaatacct attttctcat attctgacct
     3781 tacatatgaa acagagcttt gtgttatcat actctctggc atactttcaa agcctttgct
     3841 catctcttta gtcaatgtat ctaactgttc ctttggcatt gctgataaca atttaaatat
     3901 atcaacatct ccactttgag tagcttgtgg tggaagtttg ctcattaact gagctttcat
     3961 agcttttacc tctttactat cgccctcaag ccctgatact attaaaatag ctttaccaaa
     4021 aataacattt aaatcatcta tagtgtcttt gtctttagta tttaactcat aaagagattc
     4081 atcttttaga cctgggtact tatctttata cttaacataa tcctttttat tcagcaaagt
     4141 ataattatct agtactttat ccttactact tttatccata aataaagtaa ttttatttaa
     4201 ttcactctct ctaatcacag atggaacaga gttttctact ccaccttgtt gtatacctac
     4261 atttactata ttggatgtgt attctggtaa agaaaggtca cataccgctt gaattaccaa
     4321 tagacagact attattacta ttgataatgc cgatttcttt aaatatttaa ttaatttaaa
     4381 catacatttc ttcccttctg taatattaat tagtctaata acattaaatt gaaaaacatt
     4441 attttaaact ttaaaaatat ttttcatctt catgcttatg acatcctgct tttaaattat
     4501 ctcgtacttg cattagaagt cttctaagta ctattttttc ttcttcacta aatcctaaaa
     4561 aaaactctct ttccaattcc ttgttaaatt cttcaacttt attacatatt tctaaacctt
     4621 tgtctgtcaa aaaaatccta gatactcttt ggtccttttc atcttgtttt ctttccacaa
     4681 gtccagcttt ttccatcctc tttatcataa ctgtagttgt agatgctttt actttccttt
     4741 tatctgctaa ttctttttga ctttgcccat ctttcatctt taaagaaaaa agtatttggg
     4801 gttgaccatg atataagcct aatttatcaa aataaaaatg agttcttata aaatatattc
     4861 gcattaattg caagaaaaca tcatttaatt tttcttcaga attgctattc atacttgccc
     4921 tccttatttt ttatattact tagtcagcta agtattattt tactatactg catgcatttt
     4981 ttcaatatat ttataaaaaa ttcatataaa tttcatttat taaatatttt tatatcatat
     5041 agttataatt ttaataaata atagtaagat ttttaattag tcagctactt atatttttta
     5101 ttgcaaagct taaaataaac cttttcatat attttcaaat aaaaaagttg tcccaaaata
     5161 aattttgaaa caacatcata ttcaacagta tcttgattat ataacattat gatactctac
     5221 ttatcttcat atccatttac aacaacgtct aacttcccag tttcaggtga tataattaga
     5281 ccatgtacaa taataccatc tggaattaaa ggatgccctt ttattaaatc aatactatct
     5341 tttacagatt cttctgcaga atcgaatcca tgtaaccatt gttttgtatc aattccagca
     5401 ctacgaagtg taagtattac atcattagat attcctctat ctaaaatttt accaagtaac
     5461 ttatccgtat caacattaca cataccacat ccatgatgcc ctacaaccat aacctcatct
     5521 acatcaaatt cgtaaattgc aactaaaaca cttctcataa tacttccaaa aggatgcatt
     5581 atagtagctc ctgcattttt tattagtttc acatctccat ttttcaaatt catagcctta
     5641 ggcaaaagct cagttaatct tgtatccata caagataaga ctactatttt tttatttgga
     5701 tgttttgatg tcacatattg ttcatattct ttgttctcta caaatgattt attatattct
     5761 aatatctctt caagttttct catatgtaat atcaccctct ttaaaaattt ttttatta
//
LOCUS       DAEQCW010000161         5813 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.162, whole genome shotgun sequence.
ACCESSION   DAEQCW010000161 DAEQCW010000000
VERSION     DAEQCW010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5813)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5813)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5813
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.162"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            52..2283
                     /gene="pflB"
                     /locus_tag="KRO40_003369"
     CDS             52..2283
                     /gene="pflB"
                     /locus_tag="KRO40_003369"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HBH2094165.1"
                     /translation="MNAWQGFKTGRWTKEINVREFIQLNYSPYEGNDSFLAGATENTK
                     KLWDEAMVLFKKERENGGTLDVDTKTVSGIAAYAPGYLDKELETIVGLQTDAPLKRAV
                     MPYGGIKMVENSCEAFGYELDPEIKDIFTKYRKTHNQGVFDVYTPEMRAARKSGIITG
                     LPDAYGRGRIIGDYRRVALYGVDALIEDKNEQKKSLEVSCMDEEVIRLREEITEQISA
                     LNELKKMAESYGFDISKPATNSKEAVQWLYFGYLGAVKDQNGAAMSLGRTSTFLDIYF
                     ERDLKAGIVTEEELQEYMDHFVMKLRMVKFLRTPDYNNLFSGDPTWVTECIGGMGIDG
                     RTLVTKNSFRMLNTLYTLGPSPEPNLTVLWSTKLPQGFKDFCSKVSIDTSSVQYENDD
                     LMRAYWGDDYGIACCVSAMRIGKQMQFFGARVNLAKTLLYAINGGVDEKSGVQVGPRF
                     EPITSEYLDYDEVMSKFEPFTDWLATLYVNTLNVIHYMHDKYSYEALEMALHDRDIFR
                     TMACGMAGLSVCADSLSAIKHAKVKTIRNEQGIAVDFEIEGDYPKYGNNDDRVDSIAV
                     ELVESFMNKIRKNKTYRNSYPTQSILTITSNVVYGKKTGNTPDGRRAGAPFAPGANPM
                     HGRDTNGALASLSSVAKLPYEHAQDGISNTFSIVPAALGKDMTERINNLSAMMDGYFA
                     QNAHHLNVNVFDRATLEDAMEHPEEYPQLTIRVSGYAVNFIKLTKEQQLDVINRTFHG
                     KMA"
     gene            2443..3177
                     /gene="pflA"
                     /locus_tag="KRO40_003370"
     CDS             2443..3177
                     /gene="pflA"
                     /locus_tag="KRO40_003370"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HBH2094166.1"
                     /translation="MIKGKIHSIETFGTVDGPGIRYILFFQGCPLRCKYCHNRDTWDI
                     KSGKEYTVDEIITDALKYTSFMKFSGGGITASGGESTLQPEFLSELFKKAKENDIHTC
                     LDTSGFVDIETIDPVLDNTDLVLLDLKHMVEEKSIDLTGVGMDKALKLARHLESRNIP
                     VWIRHVLVPGITDDIDNLEKLGQFVATLKNVERFELLPYHSMGIHKWESLGIDYELKD
                     VPDATKEDVQKASEIISKFGVKVYNS"
     gene            complement(3299..4969)
                     /locus_tag="KRO40_003371"
     CDS             complement(3299..4969)
                     /locus_tag="KRO40_003371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF and EAL domain-containing protein"
                     /protein_id="HBH2094167.1"
                     /translation="MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAI
                     FDEFNLSKEIESDLVNCWSKIVYPDDVQIWKDDIQELLHGKKGEHNLEYRLINKYKEI
                     VWISCRGKVYVSDDPKTIFLVGRIKNIGEKNKFDSITGTWNREQFEHRMNYLIKEKIY
                     KNGAMFIMDIDNFKNINEKYGHSYGDKVLRAIATEVLEYLPKDVRLYRLDGDEFAFFY
                     PMCTKETIEKIYEKIQMYTNTQHEIESNKYYCTVTAGVAMYPEDGDNYLDLFKHADIA
                     LDIAKISGKNRIKFFSQELYENKLKVISMQQKLRECVENNFNDFELFFQPQVNAVTKE
                     VIGAEVLLRWHSSTYGEVSPVEFIPILEQSNLIIPVGKWIIKEAVKQCKEWHKINPDF
                     KISVNVSYIQLKEDFFRDFIVECLVEYQLRPEFLILELTENCWIPDINLLNDKFISLK
                     GIGVYIAIDDFGTGYSSLNYLKELSVNIIKIERSFVKNITYNSYEYTFLEYIIKLAHI
                     INLKVCVEGIESYEEYDIVKSLGVDIIQGFLFGRPVSASEFYKFQLSK"
BASE COUNT         2052 a          826 c          832 g         2103 t
ORIGIN      
        1 attaatttta atagtattat ttatcattta aatctaagga ggaaatactt aatgaatgca
       61 tggcaaggat ttaaaacagg aagatggact aaagaaataa atgttagaga gtttatacaa
      121 ttaaactatt ctccatatga gggaaatgac tctttcttag ctggtgccac tgaaaatact
      181 aaaaaattat gggacgaagc aatggtccta tttaaaaaag aaagagaaaa tggtggtact
      241 ttagatgttg atacaaaaac tgtttctgga atagctgcat atgctccagg atatttagat
      301 aaagaattag aaacaatagt tgggttacaa acggatgccc ctttaaaaag agctgtcatg
      361 ccatatggtg gtataaagat ggttgaaaat tcatgcgaag cttttggata tgaattagac
      421 ccagaaataa aagatatatt tactaaatac agaaaaacac acaaccaagg agtttttgat
      481 gtttatactc cagaaatgag agctgctaga aaatctggta taataacagg tcttccagat
      541 gcttatggta gaggtagaat aattggtgac tacagaagag ttgctctata tggtgttgat
      601 gctttaatag aagataaaaa tgagcaaaag aaatcattag aagtttcttg catggatgag
      661 gaagttatca gattaagaga agaaataact gagcaaatat cagctttaaa tgaacttaaa
      721 aaaatggctg aatcttatgg atttgatata tcaaaaccag caactaactc aaaagaagct
      781 gtacaatggt tatactttgg ttatttaggt gctgttaaag accaaaatgg tgctgcaatg
      841 tctttaggta gaacatctac tttcttagat atatactttg aaagagattt aaaagctgga
      901 atcgtaacag aagaagaatt acaagagtat atggaccatt ttgttatgaa attaagaatg
      961 gttaagttcc taagaactcc tgattacaat aacttattct ctggagaccc aacttgggta
     1021 actgagtgta taggaggtat gggaatagat ggtagaacat tagttactaa aaactcattt
     1081 agaatgttaa atactctata tacattaggg ccttctccag aaccaaactt aacagttcta
     1141 tggtcaacta aattacctca aggattcaaa gatttctgtt ctaaagtatc tatagataca
     1201 agttcagtac agtatgaaaa tgatgattta atgagagcat actggggaga tgactatggt
     1261 atagcttgtt gtgtatctgc aatgagaatt ggtaaacaaa tgcagttctt tggagctaga
     1321 gttaacttag ctaaaacttt attatacgct ataaatggtg gtgtagatga gaaatctggt
     1381 gttcaagttg gaccaagatt tgaacctata acttctgagt acttagatta tgatgaagtt
     1441 atgagtaaat ttgaaccatt cactgattgg ttagcaacat tatatgtaaa tactttaaat
     1501 gtaatacatt atatgcatga taaatattct tatgaagcat tagaaatggc attacatgat
     1561 agagatatat ttagaactat ggcttgtggt atggctggat tatcagtttg tgcagactca
     1621 ttatctgcta taaaacatgc taaggttaaa actattagaa atgaacaagg aatagctgtt
     1681 gattttgaaa tagaaggaga ttatccaaaa tacggaaata atgatgatag agttgatagt
     1741 atagctgtag agttagttga aagctttatg aataaaataa gaaagaataa aacttataga
     1801 aattcttatc ctactcaatc tatacttaca ataacttcaa atgttgtcta tggtaagaaa
     1861 actggtaata caccagatgg tagaagagct ggtgctccat ttgctcctgg tgctaaccca
     1921 atgcatggta gagatactaa tggtgcttta gcttcattat cttcagttgc taaattacca
     1981 tatgaacatg ctcaagatgg tatatctaat actttctcta tagtacctgc tgctttagga
     2041 aaagatatga ctgaaagaat aaacaatctt tctgcaatga tggatggata cttcgctcaa
     2101 aatgctcatc acttaaatgt aaatgtattt gatagagcta ctttagaaga tgctatggaa
     2161 catccagaag aatatccaca attaactata agagtatctg gatatgcagt taacttcata
     2221 aaattaacta aagagcaaca attagatgtt ataaacagaa cattccacgg taaaatggct
     2281 tagtctttaa atttttatac tttaactaag attactactg tgtaaaaaat aaaaataaaa
     2341 ggctatctta tatttgaatt atttctggta taagatggcc ttttttagag aaatattata
     2401 actattgata aggttattaa aatatattgt gaggtgaact ctatgattaa gggaaagata
     2461 cattctatag aaacgtttgg tactgtagat ggaccaggaa taagatatat attatttttt
     2521 caggggtgtc ctcttagatg caaatactgt cataacaggg atacatggga tattaaatca
     2581 ggaaaagaat acacagttga tgaaataata acggatgctc ttaagtatac ttcttttatg
     2641 aagttttctg gtggaggtat aactgcctct ggtggtgaat ccactcttca accagaattt
     2701 ttaagtgaat tatttaaaaa agcaaaagaa aatgatatac acacttgctt ggatacatct
     2761 ggatttgtag atatagaaac tatagaccca gttttagata atactgattt ggttttactt
     2821 gatttaaaac atatggttga ggaaaaatct attgatttga ctggtgttgg tatggataag
     2881 gcattaaaac ttgctagaca cttagaatca agaaatattc ctgtatggat aagacatgtt
     2941 ttagttcctg gcattactga tgatatagat aatttagaaa aactaggtca atttgtagct
     3001 acattgaaaa atgtagaaag atttgaattg ctaccatacc attctatggg aatacacaaa
     3061 tgggaaagtt taggtatcga ttatgaacta aaagatgttc ctgatgccac taaggaagat
     3121 gtccaaaaag ctagtgaaat aatctctaaa tttggagtga aagtatataa tagttagtgt
     3181 agtatattaa tcctttatag aagacataac aaaatagggt aaagtgtaaa tttttaataa
     3241 acttcaaaac ttccactttg ccctattttt atatactata tatctcattt tatatacatc
     3301 actttgatag ttgaaattta taaaattcag aggcacttac aggtcttcca aataaaaaac
     3361 cctgaataat atctacccct aagcttttta ctatatcata ctcttcataa gactctattc
     3421 cctcaacaca aacttttaaa tttataatat gagctaattt aataatatat tcaagaaaag
     3481 tatattcata actattatat gtaatattct taacaaaact tctttcaatt tttattatat
     3541 taacagacag ttctttaagg taatttaaag atgaatatcc tgtaccaaag tcatctattg
     3601 caatatatac tcctataccc tttaaactaa taaatttatc atttagtaaa tttatatctg
     3661 gtatccaaca attctctgtt aattccaaaa ttaaaaattc aggtcttaat tgatactcta
     3721 ctaaacattc tactataaaa tctctaaaaa aatcttcctt taactgaata tacgatacat
     3781 ttacagatat tttaaagtct ggatttattt tatgccattc tttacactgt tttacagctt
     3841 cttttataat ccacttccca actggtataa ttaaattact ctgttctagt attggtataa
     3901 attcaacagg agatacttct ccataagtac tcgaatgcca tcttaaaagt acctctgccc
     3961 ctattacctc ttttgtaaca gcatttacct ggggttgaaa aaacagctca aagtcattaa
     4021 aattattttc aacgcactct cttagttttt gttgcattga aattaccttt agtttatttt
     4081 catagagctc ttgtgaaaaa aacttaattc tatttttacc actaattttt gctatatcca
     4141 atgcaatatc agcatgttta aataaatcta aataattatc tccatcttct ggatacatag
     4201 caacgcctgc agtcactgtg caatagtact tatttgattc aatttcatgc tgagtatttg
     4261 tatacatctg tatcttttca tatattttct ctatagtttc tttagtacac atagggtaaa
     4321 aaaatgcaaa ttcatctcca tctaacctat acaatcttac atcttttgga agatattcta
     4381 atacttcagt agcaattgca cgcaatactt tgtcaccata agaatgtcca tatttttcat
     4441 ttatattttt aaaattatca atatccataa taaacatagc accattttta taaattttct
     4501 cttttataag ataattcatt ctatgttcaa attgttctct attccacgtt cctgtgatag
     4561 aatcaaattt atttttttca ccaatattct ttattctccc gactagaaat atagtttttg
     4621 ggtcatccga cacataaact ttacctctac aagaaatcca tactatttct ttatatttat
     4681 taatcaacct atattctaaa ttgtgctcac ctttttttcc atgtagtaat tcttgtatat
     4741 catctttcca tatttgaaca tcatccggat aaacaatttt actccaacaa ttgaccaaat
     4801 cagattctat ctctttactt aagttaaatt catcaaaaat tgctgaagaa attttaaatt
     4861 tattcctatt tatatcccaa aaaaatatat aatcttctgt actttgagat aaaagttcaa
     4921 agaaaatttc tatatggtct aaacttaaag agttcgattc ttctctcatc ttttccccct
     4981 acaatattac tattagtgta gtttaatcaa caaaatatcc ttatttagat tatactattt
     5041 tactaatttt ttgtctcatc aaacacattt ccccaacttt agttatctta tcaaatctct
     5101 tactcttaac taagtttttt gagattcata aagtaatttt tctataatca ttactggtga
     5161 tttattttta cctgctaaaa caccatgtta aatcatttat taaatcattt tctcttaaaa
     5221 ttctattttt cgttatataa agagttatca gttctttatt ctataaaact tttctattac
     5281 tcttgaattt attttatttt tttcttcgcc tattctcttt ggatttggta ttgcttttct
     5341 atagattttg gcaaagaagt gtctcttcct ataatataag attttgatat ttcttcatca
     5401 tctataaatt ttttaatagg gattatatca ttttttatat ttatttatat aaatattttt
     5461 tgtttttaat tttttctatc ttcttatgta cttacattta atttattctt ttcagttaat
     5521 aaaataggta catttttagt acatgaaaat agagttgctt acagggtata taggattgat
     5581 gtactattta ctaatattac attttcaact gattcaaccc ctcttttact tacataattt
     5641 aagtatattt ttctggattt ttaaatttat gtactttaaa atggatatac ttattttcat
     5701 tgattttgta agaattaata aaaaatacga ttacactaca aaattagaat gtcaatgttt
     5761 ataaatataa aataatattt tttattttaa ttattacatc catagtttcc att
//
LOCUS       DAEQCW010000162         5731 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.163, whole genome shotgun sequence.
ACCESSION   DAEQCW010000162 DAEQCW010000000
VERSION     DAEQCW010000162.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5731)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5731)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5731
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.163"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            235..417
                     /locus_tag="KRO40_003372"
     CDS             235..417
                     /locus_tag="KRO40_003372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094168.1"
                     /translation="MFKDKIDECVHIMTAYIASLKEYYSFIETQIGDFIKKYGEDVVE
                     LCLHRVMILLCECGLA"
     gene            1249..2163
                     /locus_tag="KRO40_003373"
     CDS             1249..2163
                     /locus_tag="KRO40_003373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2935 domain-containing protein"
                     /protein_id="HBH2094169.1"
                     /translation="MIDNQKYVILSLELHLFFSRIMKEHALFLEAGFTNKNYNLAMEA
                     DHYKKQFEDLLSYTVSASNGIIRPDILYSEELVTTLTSVAEQKTEEFTGIEINKNITT
                     RELNLQSGVNPQVGQDLVNYVAQLNSDAIRLLDGLINFKERVLDGVLSCTIFTSNYPL
                     LLEHIIHEANLYRSYVVDLENKIDIESKNAKEIELFWDHIMMEHALFMRGLLDPSEGE
                     LINTSNDFAIKFNELIEKTNEMTDSNIKNITEETLNETVEFKDFKEAGASGIEQCKIK
                     SIILPLLADHVLREANHYIRILESYKNM"
     gene            2553..3200
                     /locus_tag="KRO40_003374"
     CDS             2553..3200
                     /locus_tag="KRO40_003374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBH2094170.1"
                     /translation="MIRQTPLEKRYDKLGPHIVTALKKRYFDAYYCKTRNEALQQILD
                     LIPQNHVVSWGGSETLKEMGVQTAVREKGFKVIDRDLAKTPEERTEIMRQALLCDTFL
                     MSSNAISEDGQLFNIDGNGNRVAAMIFGPKNVIVVAGMNKIVKNIDDAIQRTRTIASP
                     AVVQRFQDVNTPCYINGSCIDCTSPESICAYMVTTRISRPAKKIKVILVGENLGL"
     gene            complement(3367..3936)
                     /locus_tag="KRO40_003375"
     CDS             complement(3367..3936)
                     /locus_tag="KRO40_003375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBH2094171.1"
                     /translation="MKKFIICIIMFAISVLVLAGCTNDNKIKNEVDSMFNSIKTQDAD
                     TVDKYFPKSGLGNLIYEDKEGFKMYSKNMTWEISDIKNNKDKVTVDLKINNTDMVSIL
                     KKNPPKLGEMMPNPTMKDIDSAKKKEFNITLELVKSGDNYVCKVNQESAMKLLNVITG
                     GGIDYLADYNKDYYKQLDEEQKNYENKNS"
     gene            complement(3941..4840)
                     /locus_tag="KRO40_003376"
     CDS             complement(3941..4840)
                     /locus_tag="KRO40_003376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2094172.1"
                     /translation="MKLLSKVNNNIRLITQVAFTALTNGYVNGFLEGTIYGGESKKLC
                     VPGLNCYSCPGALGACPIGSLQAVLSSREYKFSFYVVGFLMAFGAFFGRFVCGWLCPF
                     GLVQDLLHKVPFPVKIKKVYGDKYLKYLKYIVLIMFVIILPVAIVNVAGGGNPWFCKW
                     ICPSGTLLGGIPLILGNENLRESIGFLFSWKLSILLLILLMSIITYRPFCKYICPLGA
                     IYGFFNPISIYRFKIDKDKCTNCTACQTKCKLDIPIYKDVNSPDCIRCGECIKVCPQN
                     AITTTFSKDKKENNICAKKYRGI"
     gene            complement(4851..5000)
                     /locus_tag="KRO40_003377"
     CDS             complement(4851..5000)
                     /locus_tag="KRO40_003377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094173.1"
                     /translation="MSNFIKDNKKSISIIAISIIFIALGTYRGETNTVLTKAIMICLE
                     CIGIG"
     gene            complement(4993..5577)
                     /locus_tag="KRO40_003378"
     CDS             complement(4993..5577)
                     /locus_tag="KRO40_003378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA family protein disulfide reductase"
                     /protein_id="HBH2094174.1"
                     /translation="MKRFFIVVLGCICVLGMISGCSKKESKPVEKNKNNSEWFSNLDT
                     EDVDGNKVTKEIFSNKELTLINVWTTWCGPCVGEMPELEALSKEYESNNSNVAIKGLV
                     VEVDKTDMRTGLSNEEKNLVKDIMKKSDATYQQLTVSEELKKTDFKRVMEFPTTYFVD
                     KKGNFVGEKVVGANSKEDWKKIIDERLKMVKANE"
BASE COUNT         2101 a          861 c          659 g         2110 t
ORIGIN      
        1 tattaattta tattaaatat ctactaactc aaatattcat aattaaactt taaactggat
       61 aaattttctt ttaagaatga aagtttatcc agttttgcga ttataataac cagttttaca
      121 tatccacttg taaaatatat ctaagcaata tatcatacta tatagattta tgagtgaaat
      181 aatatctgct atttactgaa tatttttatt tttcgttttt tagggggatt agttgtgttt
      241 aaagataaga ttgatgaatg tgttcatata atgactgcat atattgctag tttaaaagaa
      301 tactattcat tcatagaaac tcaaattggt gattttatta aaaaatatgg agaagatgtt
      361 gtagagttat gtctccatag agtgatgatt ctactatgcg aatgtggttt ggcataaaat
      421 taaatttatt aaaatgggta agaagaatcc tatataatat tcttcttacc cattttaata
      481 tatcaatttc atagcttatc gtttaaaata ttttacatcc attactagac aactttacat
      541 tctcttttta attctagtat atttaaatca ttttagttgc tccttattta ttcttattac
      601 ttgttttatt ttataaataa aataattctt tttaataatg ttttttgttg atattcctat
      661 cacacatcca attatttatc attgtcttga aattgtttgc atacttaatt taatccaatt
      721 gaaacactcc agcatagaat cccctgtaaa atagaagttg gattaaatcc taacatctat
      781 acagaaaata ctactccaag cacaagcaat ataatggaat atatttatca cttaattttt
      841 tatacttttt aaatcccata cctaaaacat taagtgcagc tattagaatt aataattgtt
      901 gtggtataaa attatgcttg cttcatattt attcattttt tcctataaaa gttcttgttt
      961 tacaaaaaac atttgttttg tatcaaaaca atacttataa attacataat tctcataaaa
     1021 atttctaata ttacttgtac tcttaataaa taatagccaa caagcacctt aaatcattat
     1081 atctatatct aataagaaac acagtaagat aattttttcg cccataactt aataaaaact
     1141 gttgatatta gtagcaattg aatttagtta atttatttat aatatacata aatttaaata
     1201 ttacgaataa agtattataa ataggatact ttctaaaggg aggaaattat gatagataat
     1261 caaaaatatg ttattttatc actagaatta catttatttt tttcaagaat tatgaaagag
     1321 catgctcttt ttttagaagc aggattcaca aataaaaatt ataatcttgc tatggaagct
     1381 gaccattata aaaagcaatt tgaagattta ttatcataca ctgttagtgc tagtaatggt
     1441 ataattagac ctgatatatt atattcagaa gagcttgtaa ctactctcac atcagttgca
     1501 gaacaaaaaa cagaagagtt tacagggata gaaataaaca aaaacatcac tacaagagaa
     1561 ttaaatctac aaagtggtgt aaacccacaa gttggtcaag atttagtgaa ctatgtagct
     1621 caacttaact ctgatgcaat aagattactt gatgggctta ttaattttaa agaaagagtc
     1681 ttagatggtg tactatcatg tactatattt acatcaaact accctctact tcttgaacat
     1741 ataatacatg aagcaaattt atatcgttct tatgtagttg accttgaaaa taaaatagat
     1801 attgagtcaa aaaacgctaa agaaatagaa ttattctggg accatattat gatggaacat
     1861 gctctgttta tgagaggatt actagacccc tcagaaggtg aactaataaa tacttcaaat
     1921 gattttgcta taaaatttaa tgaattaatt gaaaaaacaa acgaaatgac tgattctaat
     1981 atcaagaaca ttacagaaga aactctaaat gaaactgttg agtttaaaga ttttaaagaa
     2041 gcaggagcat caggaataga acagtgtaag ataaaatcta taatattacc acttttagca
     2101 gaccatgttt taagagaggc aaatcattat attagaatat tggagagtta taaaaacatg
     2161 taattaaaaa ttacttttaa aataatcttt gcatatttag ataaaataaa ggtacagtta
     2221 actgtacctt tattttttat aaacttataa aatttaaaca agttattcat aaaataaaat
     2281 aataatcatc tataacccac aactttattt tatattaaat aaaaagtatt agtgattatg
     2341 ttttataggt atttctttat tcagttattt attaaaaact aatagtaaat cttatactaa
     2401 tcgcatattt atgttataac tatattgtaa ctattttcgt aatcttagga aaaggttact
     2461 tataaaatta accttataca ataatatatc gtataatctt aattagcata atagttacaa
     2521 tattaaaatt taaatatggg agtgatttta gtatgataag acaaacacca ttagagaaac
     2581 gatatgacaa gctaggtcct catattgtaa cagcactcaa aaaacgttat tttgatgctt
     2641 attactgtaa aactagaaat gaagctttgc aacaaatttt agatttaatt cctcaaaatc
     2701 atgtagtatc atggggagga tctgaaacac ttaaagaaat gggcgtacaa actgctgtta
     2761 gagagaaagg atttaaagtt attgatagag atttagcaaa aactccagaa gaaagaactg
     2821 aaattatgcg tcaagcactt ctatgcgata cttttttgat gagtagcaat gcaattagtg
     2881 aagatggaca actctttaat attgatggaa atggcaatcg tgtagctgca atgatatttg
     2941 gtccaaaaaa tgttatagtt gtagctggta tgaataaaat tgtaaaaaac attgatgatg
     3001 caatacaaag aactagaaca attgcatctc cagcagttgt tcagcgtttt caagatgtca
     3061 atacaccatg ctatattaat ggaagttgta tagactgcac aagtcctgaa agcatttgtg
     3121 catacatggt tactacaaga atcagtcgtc cagcaaaaaa aataaaggta atattggtag
     3181 gagaaaatct tggtctataa aatatacata catgtaaata gctctataaa taataaaatc
     3241 atatgaaata acttatttct aaaagtggta gaataaaagc ttctacaaga ctttcattct
     3301 accactttta tattctttta atttgtgttt ctatattatt aattgctccg attttcatat
     3361 atattactaa ctatttttat tttcataatt tttttgttct tcatcaagct gtttataata
     3421 atctttatta tagtcagcta gataatctat accacctcct gtaatcacat ttaataattt
     3481 cattgcagat tcttgattaa ctttacaaac ataattatca ccagatttaa caagctctaa
     3541 tgtaatatta aattcttttt tctttgcaga atcaatatct ttcatagttg gatttggcat
     3601 catttctcct agtttaggag gattcttttt taaaatagaa accatatcag tattgttaat
     3661 ttttaaatct acagtcactt tatccttatt attctttata tctgaaattt cccaagtcat
     3721 atttttagaa tacattttaa atccttcttt atcttcatat ataagattac ctaaccctga
     3781 ttttgggaaa tacttatcaa cagtatctgc atcttgtgtt tttattgaat taaacatact
     3841 atccacttca ttttttatct tattatcatt agtacaacca gctaacacta gtactgatat
     3901 tgcaaacatt ataatacata taataaattt cttcattaaa ttatatcccc ctatactttt
     3961 ttgcacaaat attattctct tttttatctt ttgaaaaagt tgtagtaatt gcattttgtg
     4021 gacaaacttt tatacattca ccacacctaa tacagtctgg actatttaca tctttatata
     4081 ttggtatatc aagcttacat tttgtttgac atgctgtaca atttgtacat ttatctttat
     4141 caattttaaa tctatatatt gaaataggat taaaaaaacc atagattgct cctaaagggc
     4201 atatatactt gcaaaatggc ctataagtaa tgattgacat caataatatc aatagcaaaa
     4261 tacttaactt ccagctaaat aaaaatccta ttgattctct taaattctca tttcctaaaa
     4321 taagtggtat tcctcccaaa agtgttcctg aagggcaaat ccatttacaa aaccaaggat
     4381 ttccaccccc tgctacattt acaatagcaa ctggcaaaat aattacaaac attattaaga
     4441 ctatatactt tagatatttt agatatttat caccataaac tttttttatc tttactggaa
     4501 agggtacttt atgtagtaaa tcttgtacaa gtccaaaggg acaaagccaa ccacaaacaa
     4561 atctgccaaa aaaagcacca aatgccatta aaaaaccaac aacataaaat gagaatttat
     4621 actctctgct tgataaaact gcttgtaatg aacctattgg gcatgctcca agtgcacctg
     4681 gacatgaata acaattcaat ccaggtacac ataatttttt actttctcct ccatatatag
     4741 ttccttctaa aaatccattt acatatccat ttgttaatgc tgtaaatgca acttgagtaa
     4801 taagtcttat attattattt actttagata ataacttcat tcctcttctc ctaaccaata
     4861 ccaatacact caagacaaat cataattgct ttagttaata ctgtatttgt ttctccacga
     4921 tatgtaccta atgcaataaa tataatacta attgcaataa tagaaatgct ttttttatta
     4981 tctttaataa aattactcat tggcttttac catttttagt ctttcatcta taattttttt
     5041 ccaatcttcc ttactatttg cacctacaac cttctcaccc acaaagtttc ctttcttgtc
     5101 tacaaaataa gttgttggaa actccataac tcttttaaaa tcagtttttt taagttcttc
     5161 agatacagtc aattgttggt aagttgcatc tgactttttc ataatgtctt taactaaatt
     5221 tttctcttca tttgaaagac cagttctcat atcagtttta tcaacttcta caactaatcc
     5281 ctttatagct acattggaat tattactctc atattctttt gataatgctt caagctctgg
     5341 catttcaccc acacatggtc cacaccaagt agtccagaca ttaataagag taagttcttt
     5401 atttgaaaat atctcttttg ttaccttatt tccatcaaca tcctccgtat ctaaattact
     5461 aaaccattca ctattattct tgtttttttc tactggctta gattcttttt tgctacatcc
     5521 agaaatcata cctaaaacac aaatacatcc taaaactact atgaaaaacc ttttcatatc
     5581 tcacactcct agaatttata tagtatataa aatcgctgct tgaaataaaa ataacttatc
     5641 ttctatatta aagtaattat atttaataaa taagagctaa tttaaaaaaa gatatacagt
     5701 taaaatctat ttcttttcag acaaaatctt a
//
LOCUS       DAEQCW010000163         5686 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.164, whole genome shotgun sequence.
ACCESSION   DAEQCW010000163 DAEQCW010000000
VERSION     DAEQCW010000163.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5686)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.164"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            18..683
                     /locus_tag="KRO40_003379"
     CDS             18..683
                     /locus_tag="KRO40_003379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094175.1"
                     /translation="MKGNIVQYNFADIEEEVYSLDYAIAWNTDEENVNIIPFTNKFCK
                     ESIESFCLGKINNFVEILNEGFVENHHYVHLDKMISVPKKKVNLVYQQDTHGYLLRDD
                     NDNLIPAKITSEQSKSISSKMELFSAGEEKCLINILLKADPSYILDVDSIKDKNILNL
                     GYESIDRYKEYNFDDDKILIFFINKKRYSVIMKKTNNSDNDLVSRNNAIKELFTNKAG
                     NLN"
     gene            complement(1189..3891)
                     /locus_tag="KRO40_003380"
     CDS             complement(1189..3891)
                     /locus_tag="KRO40_003380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2094176.1"
                     /translation="MKNVSKKFFVCTIIVLITFLCFSKFAIYVFDKQEKKETKVVENM
                     LNVYKNNIILNLTEKFNYSKDLTSVLVSNNYSIDKLKPIADEILKNNSCIYISVVEKY
                     NVAAFFSNSVKKDIINTPIQELNYSYSLANSIKGLVVEGPSKDQFSNGDVFLITNPIY
                     KNGEYWGEITVALDAKKVVDSFNLNKLKESGFEYELWRVHLDNGSKSTIEISTKDFNF
                     SKSHEIKFKLPTVWTLSIVYKNGWNNKNIDFIVFVILLIISILIGVMTFIYIEKKSIS
                     KELNQQSLKNLETGILNREGFLIKLQEHLNRKNNEIVLLYICITNYSKFAPVMSFEKR
                     QDYLTHIVKNLDNYIKSSHFIARISEEGFVLALEENCDKNELLNIEKGISLELLRKIK
                     VENKQVFLTIGYGSSRCVDDRKDAESLLLSAIEDYERRFPAMSPIHDFTKKCEDMLDE
                     KKQIVFGEYPDLEINKLSKVIYKYYKKVQRIMYKDYNIDIGNRRGYMRDVEVLIDYNS
                     ERMLYLFLIDICKFGKFNELFSIEIGDVILKEVSNKLKTIFSNYLYRINGDVFLGISI
                     DKESYLDTLHKVNEVFNSSLSVEDVLFDIKCNIGICQYPYHGENPYDLLEKVQIALEY
                     AKKDVKSNVKVYDKELTEEIYHENNIIKDLKKGLEEQTLEVWYQPIFNVSKNCYIKAE
                     ALIRLRNKEGGYYSAYEVITYAEKHGLIKDVGLYVLKKACDVTTKIKDKNIDFEQMQL
                     NLSVQQIVHKQCANDILSCIENCGLDKKYICVEVTETVLMETFEIVNVTLDKLKKEGI
                     SIALDEFGSGFSSINYLANLPIENLKIDKELVEQITYSKKQFELLKTIVQIAKINGMD
                     IVAEGVETKETLDLVVTSGVNLIQGHYFSEPLSEDKFIELMIEE"
     gene            complement(3917..5467)
                     /locus_tag="KRO40_003381"
     CDS             complement(3917..5467)
                     /locus_tag="KRO40_003381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBH2094177.1"
                     /translation="MRYKKRNIDKSSELSFQSLAKYFITFYIVIILIILSMFCINTIW
                     VMKKDNQDLLSTTSNRIEDRVGETIKLLNSLSKDNYIIDNSVNGIDKSKELSMYSDEF
                     GYMMICFVDKNIIVWDEEGGNISLAGRDYMQKLFATKKYQVTDSFAAGADGKTLNYTI
                     ASPIIKNGNVDGCVFAAIYFDEIKDILKQGKGQQQQNFILFGSENQIMNLTSDETAYG
                     EKYMKLSQKTKYLGTNAKKVEKDMFNNKSGDYWAFENGKLYFMSYKPIKNTNWSLFCK
                     VNFLDIFALNLIPMGAILSVITLVFIILICMEKSFMKKRMEVIDMLLGSVQELEKRIY
                     QTERPSEVDFKEIIQLTSKGLTDGLTGVVTRTVFFDQIYNRVEMEENDKLSVISFVDL
                     DDLKCINDLYGHEIGDMVLKNVGYVLREYEIKYNGLIGRYGGDEFVMLLSGFTSREEV
                     EDLLDEIAIRLHTEVLTDDGIIQTHCSVGAVVCSVKDNKDIDNLLKQADEALYYVKRN
                     GKGNYHLV"
BASE COUNT         2039 a          930 c          550 g         2167 t
ORIGIN      
        1 atggaggtcg agtaattttg aaaggaaaca tagtacaata taattttgca gatatagagg
       61 aagaagtata ttcgttggat tatgctatag catggaatac agacgaggaa aacgtaaaca
      121 taataccatt tacaaataaa ttctgtaaag aatctataga atctttttgc ctaggtaaaa
      181 ttaataactt tgttgaaata ttaaatgaag gttttgttga aaatcatcat tatgtacatt
      241 tagataaaat gattagtgtt cctaagaaaa aggttaattt agtatatcaa caagacacac
      301 atggttatct tctaagagat gataatgaca accttattcc tgcaaaaata acttcagagc
      361 aatctaaatc tatatcaagt aagatggagt tattctctgc tggtgaagaa aaatgtttaa
      421 tcaatatatt actaaaggct gacccatcat atattttaga tgtagatagt ataaaagaca
      481 aaaacattct aaatctaggt tatgagtcta ttgacagata taaagaatac aattttgatg
      541 atgataagat tttaatattt tttataaata aaaaacgtta ttcagtgatt atgaaaaaaa
      601 caaacaactc tgataacgat ttagtttcca gaaacaatgc tattaaagaa ttatttacta
      661 ataaagcagg aaatcttaac taataatata attttaaatt atgttattga ttaaattaat
      721 aatagtatac aaagaggctg tctcaaaata gagataagct tctttttcat tgttgaaata
      781 ataaaatata tttaattcta tataaaagag agtgcctcat aaactaaaaa gttcattttg
      841 agacaccctc ctatttataa taaacaaata aatccttaaa cctatcgagt gattataatt
      901 tttagattgg gttatcttgc atttttaaat ttaaggtaac tttctactct aaactttaat
      961 ctctaatcaa tatcatcaac tgtaacaact tacaattaaa tctttaataa tcaaacttta
     1021 gactatctat attaaaactc aaattagatt taggatttat ttggatatca catttatttt
     1081 attaactact aatcaattat ttttacttat aaacttattc ttccctaatt ctattattaa
     1141 atacttttaa ttatttttca ataccttaaa tctttatttt attaaccttt attcttcaat
     1201 cataagttca ataaatttat cttcacttaa aggttctgaa aaataatgac cttgaatcaa
     1261 attcacacct gaagttacaa ctaaatccag agtttctttt gtttcaacac cttctgctac
     1321 aatatccatg ccattaatct tagcaatttg aactatagtt tttaataatt caaattgttt
     1381 tttagaatag gtaatttgtt ctactaattc cttatctatt tttaaatttt caataggtaa
     1441 atttgccaga taatttatac tactaaatcc agaaccaaac tcatctaaag ctatgctaat
     1501 gccttctttt tttagtttat caagagtaac atttacaatt tcaaaagttt ccataagtac
     1561 tgtttctgta acttcaacac aaatatactt tttatctaga ccacaattct caatacatga
     1621 taatatgtca tttgcacact gcttatgtac aatctgctga acagataaat ttaattgcat
     1681 ttgttcaaaa tctatatttt tatcttttat ttttgtagtt acatcacaag ccttttttag
     1741 tacatataga cctacatcct taataagtcc atgcttttct gcataagtaa taacttcata
     1801 ggcagaataa taaccgccct ctttatttct caatctaatt agtgcctcag cttttatata
     1861 acagttttta ctaacattaa aaattggctg ataccaaact tctagtgttt gttcttccag
     1921 accttttttt aaatccttaa taatattatt ttcatggtaa atctcttctg tcaattcctt
     1981 atcataaact ttaacattac ttttgacatc cttttttgca tactccaatg caatttgtac
     2041 cttttccaga aggtcatatg gattttcacc atgatatgga tattgacaaa taccaatatt
     2101 acattttata tcaaaaagta catcttctac acttaaagaa ctattaaata cttcattaac
     2161 cttatgtaaa gtatctaagt aagattcttt atctattgaa atgcctaaaa atacatctcc
     2221 attaatacga tatagataat tagaaaaaat tgtttttaat ttgttactaa cttcttttaa
     2281 aataacatct cctatttcaa tagaaaacag ttcattaaat tttccaaact tgcatatgtc
     2341 tattaaaaat aagtataaca ttctctcaga attataatca attaatactt cgacatcacg
     2401 catataccct cgtctatttc caatatcaat attataatct ttatacataa tacgctgtac
     2461 ttttttataa tatttgtata ttactttaga caacttgttt atttctaaat ctggatattc
     2521 accaaataca atctgtttct tttcatcaag catatcttca cactttttag taaaatcatg
     2581 aataggagac attgctggaa atcttctctc ataatcttca atagctgaaa gtaacagaga
     2641 ttctgcatct tttctatcat caacacacct agatgagcca taaccaatcg ttaaaaatac
     2701 ttgtttattt tctactttaa tttttcgtaa aagctctaag gaaatccctt tttcaatgtt
     2761 aagcaattca tttttatcac aattttcttc taaagctaga acaaaacctt cctcacttat
     2821 acgagcaata aaatgagaac tttttatgta attatctaga ttttttacta tatgtgtaag
     2881 ataatcttgt cttttttcaa agctcataac tggagcaaat ttactataat tagtaataca
     2941 tatatacagc aacactattt cattattttt tctattcaga tgctcttgta acttaattaa
     3001 aaaaccttct ctattcaaaa taccagtttc taaattttta agactctgtt gatttaattc
     3061 cttactaatc gacttctttt caatgtaaat aaatgtcatc acacctatta atatggaaat
     3121 aattaacaat ataacaaata caataaaatc tatattctta ttattccatc catttttgta
     3181 cacaatgcta agagtccaaa cagtcggaag tttaaactta atttcatgtg atttggaaaa
     3241 attaaaatct ttagtagaaa tttctattgt agattttgaa ccattatcta gatgtacacg
     3301 ccaaagttca tactcaaatc cagattcttt taatttattt aagttaaaag aatctacaac
     3361 ttttttggca tctaaagcta ctgtaatttc tccccagtac tctccatttt tataaatagg
     3421 attagtaatt aaaaacacat ctccatttga aaactggtct ttagaaggac cttctacgac
     3481 taatcctttg atagaatttg ctaatgaata agaataattc agttcctgta ttggagtatt
     3541 gataatatct tttttgacag aattagaaaa aaatgcagct acattatatt tttctacaac
     3601 tgaaatatat atgcaagaat tgtttttaag aatttcatct gcaataggtt ttaatttatc
     3661 tatagaataa ttgtttgaaa ctaaaactga tgtcaagtct ttgctataat taaatttttc
     3721 agtcagattt aaaataatgt tattcttgta gacatttaac atgttttcta ctacttttgt
     3781 ttctttcttt tcttgtttgt caaaaacata aatagcaaat ttactaaaac ataaaaatgt
     3841 tattaataca ataatagtac atacaaaaaa ttttttagat acatttttca tatgatataa
     3901 actccttcca catacattaa actaaatgat aattaccttt tccattacgt ttaacatagt
     3961 ataaagcttc atcagcctgt tttaataaat tatctatatc tttattgtct tttacactac
     4021 atactacagc tccaacacta caatgagttt gaatgatacc atcatctgtt agtacttcag
     4081 tatgtaagcg aatagcaatc tcatccaata aatcctccac ctcttctctc gatgtaaaac
     4141 cagataacaa cataacaaat tcatctccac catagcgccc aattaaacca ttatatttta
     4201 tctcatattc acgaagtaca tatccaacat ttttcaaaac catatcccca atttcatgtc
     4261 catataagtc gttaatacat ttcaaatcat ctaaatcaac aaatgaaatt acagataatt
     4321 tatcattttc ctccatttca acacgattat aaatttggtc aaaaaataca gtacgtgtta
     4381 caacaccagt taatccatca gtcagacctt tacttgtgag ctgaataatt tctttaaagt
     4441 ctacttcact aggtctttct gtttgatata tacgtttttc taattcttga acagaaccta
     4501 aaagcatatc aataacttcc attcgttttt tcatgaagct tttctccata caaatcaaaa
     4561 taataaatac taaagttata acagatagaa tagctcccat aggaattaaa tttaatgcaa
     4621 aaatatctaa gaaattaact ttacaaaata aactccaatt tgtgttctta attggtttat
     4681 aggacataaa gtataatttt ccattttcaa aagcccaata atcacctgat ttattattaa
     4741 acatatcctt ttctactttt tttgcattgg ttccaagata ttttgttttc tgcgataact
     4801 tcatatactt ctctccatat gcagtttcat cacttgttaa attcattatt tgattttcac
     4861 ttccaaataa tatgaaattc tgttgctgtt gaccttttcc ttgtttgagt atatccttta
     4921 tctcatcaaa gtaaattgct gcaaatacac aaccatctac atttccattc tttattatag
     4981 gtgatgcaat agtgtagttt aaagtttttc catcagcccc tgctgcaaaa ctatctgtaa
     5041 cttgatattt ttttgttgca aaaagtttct gcatataatc acgaccagct agactaatat
     5101 taccaccttc ttcatcccat acaattatat tcttatcaac aaaacatatc atcatatacc
     5161 caaattcatc actatacatt gaaagttctt tacttttatc tatgccattc acactattat
     5221 ctattatgta attatcttta ctcaaagagt tcaatagctt aattgtttct cctaccctat
     5281 cttcaatacg atttgacgtt gtagataata aatcttgatt atcttttttc ataacccata
     5341 ttgtatttat acaaaacata gaaagaataa ttaatataat tactatatag aaagttataa
     5401 aatattttgc tagagattga aatgaaagtt cacttgactt atctatattt ctttttttgt
     5461 acctcataat tcctaccccc actatagaaa aattgatgaa aatgttccta ttagaacctt
     5521 aataatacat tacaaaacac ataatttcaa gtaaaacgtt aaattttcat tactaaatat
     5581 aaacttttta ttacaatatt attttttata tcctattata gccaatacta tcacatattt
     5641 agtaattata tctattcatt ttacaaattt tgatacgtaa tttata
//
LOCUS       DAEQCW010000164         5666 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.165, whole genome shotgun sequence.
ACCESSION   DAEQCW010000164 DAEQCW010000000
VERSION     DAEQCW010000164.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5666)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5666)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5666
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.165"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            182..1507
                     /gene="cdeA"
                     /locus_tag="KRO40_003382"
     CDS             182..1507
                     /gene="cdeA"
                     /locus_tag="KRO40_003382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MATE transporter CdeA"
                     /protein_id="HBH2094178.1"
                     /translation="MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVG
                     SDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLIV
                     GILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGN
                     SKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKST
                     LKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALKLAGENGLAALTIVLY
                     AHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIIALVFA
                     PFIVRVFVSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSR
                     AFVFIIIGIIILPPMLNMTGLWLTVPFAEVITIFISILFIKKYKCRYKY"
     gene            complement(1602..2396)
                     /locus_tag="KRO40_003383"
     CDS             complement(1602..2396)
                     /locus_tag="KRO40_003383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094179.1"
                     /translation="MNELKPYIKFFNKNTKLYIIIFMIVGIVMNILPVFILKIFGEAS
                     KTNLSTIVNPILTYITILLFVYGVNIANKDFSGALSIRADRKSCIKAIVIDLIILSFV
                     ISILGIVLIFLSKLFIEIITGYSIELSVLLKRDMIWTSISALIDPSTSSMPLTYLNYF
                     VQICINEICIGFIGVLLGAFTYRVRKVTSITILIGLPILMIIYIVNFATKNMHKMLLY
                     LEKIIYSFQNPFILFGTKVGIIVICIIFIILLLRKAPIKEYANDLL"
     gene            complement(2397..3272)
                     /locus_tag="KRO40_003384"
     CDS             complement(2397..3272)
                     /locus_tag="KRO40_003384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094180.1"
                     /translation="MSSSIKIENLSHSFKKQNIFNNMSLNFEKNKIYGLLGKNGAGKT
                     TLLNIMVNQLIQNEGEIEILGKNPKEDIKVLEEVCIVREKEFYSPDFKVGQIFEFSSS
                     FYKSYDKGLEEELCKYFDLNTKKKYKQLSRGMKTILSNIIGICSNSAITIFDEPTIGL
                     DAVNRQEFYNIILDSYIKNPRTIIISTHLIDEIDDLLEHVIILNEGKIIIDEEIDVIK
                     QKAHYITGNKEELEKLECIKNIKPKKAFGNAVAYFYYGDFSENDEKILKNSNIDVGYI
                     GLQDMFVNMTKKEEL"
     gene            complement(3276..3644)
                     /locus_tag="KRO40_003385"
     CDS             complement(3276..3644)
                     /locus_tag="KRO40_003385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2094181.1"
                     /translation="MKLVLNNEEPIFIQIARAIEDEILSNGIKEEEQVPSTTELSKLY
                     KINPATVLKGINILVDKNILYKKRGIGMFVSDGAKTIIKEARKENFKHNFVKNLLQEA
                     NKLEINREELVDIIINFKED"
     gene            complement(3827..4486)
                     /gene="deoC"
                     /locus_tag="KRO40_003386"
     CDS             complement(3827..4486)
                     /gene="deoC"
                     /locus_tag="KRO40_003386"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HBH2094182.1"
                     /translation="MKHILKTVDHTILKATTTWEDIKILCDEAVDMSVASVCIPPSYV
                     KRASEYLKGKIKICTVIGFPLGYQTTATKVFEAKDAIENGADEVDMVVNISDIKNKDY
                     DNIGKEIKEIKKAIGDKVLKVIIETCYLDEDEKIKMCEIVTMSGSDFIKTSTGMGTGG
                     ATLEDIKLMKEHVGKNVKIKAAGGVKSISDAEKFIEAGAERLGTSSICKILKNEDTTD
                     Y"
     gene            complement(4522..>5666)
                     /gene="murJ"
                     /locus_tag="KRO40_003387"
     CDS             complement(4522..>5666)
                     /gene="murJ"
                     /locus_tag="KRO40_003387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBH2094183.1"
                     /translation="GIIFIGITSVMSAFLQIKENFIVVGFGSIPYNIVIIISIMLSTV
                     FGPYILPIGAVVAMVVQLLFYMFFVKKTNYKYLYYLNFKDDSLIKLLALLSPVFIGVA
                     VNQVNSLVDTTLASTLVKGSIPALTYADRLNGFVTGTFTASIVSVMYPMLSKLSAENN
                     QKKFTSSVKSSINMIIISMIPISVASIFFATPVVRIIFERGAFDARATQMTATALIFY
                     AVGMTAFGLRDILGKVFYSLQDTKTPMVNGIISVGVNIVLDLVLIKPMAHGGLALATS
                     SSSIACILLLFLNLKRKVGYFGQDKIIKATLKSVVASLIMGVLSYFTYKFIFGILGVG
                     TFNEFVSLAISVIVGGGIYTLLMTIFKVEEVDMILNIAKRKLHLKK"
BASE COUNT         1895 a          873 c          628 g         2270 t
ORIGIN      
        1 ttttcttaag aaacagttag attttactaa tataagttta ttaattagca ctatactaat
       61 ttatcttaat atgatttttt gttgatttta agctgtttat cgtataaata aaatttttct
      121 tgactatata gttactatat agcttattat atatagagag taataaaagg aggtaaaatt
      181 tatggaaaat ttatttacaa gaaaattcac tacttttgaa tttctaaaat ttgtttctcc
      241 tgcaattata tccatgatat ttatatcttt gtatacaata atagatggca tctttgtatc
      301 gacattagtt ggttctgatg ctcttgctag tataaatatt gtactaccta taattaacct
      361 tgtttgtgga tttggaataa tgatggcaac tggtggaggt gctatcgttt ctatacgtat
      421 gggtgaaaat agacaggatg aagccaactc tacattttct tttatagttt tgttttcatt
      481 gattgttggg attttattca cagtaatctc atatttcttt atcaaagaaa tatctatttt
      541 gcttggtgca acagataagt tattaccata ttgtataact tatggtaaag ttatgatttt
      601 atgtacacca ttttatattt taaaatttat atttgagtac tttgcaagaa ctgatggaaa
      661 ttctaaattt agtttatttc tatcagtcat tggtggtgta acaaatataa tattggatta
      721 tgtatttatt aaatattttg gaatgggtct tttaggagct gcagttgcaa ctgctatagg
      781 tattatttta acttgtgttt taggtattat ttacttctta tctaataaat ctacactaaa
      841 attaagaaaa ccaaaaaccg attttagact tataagagat actatgataa acggttcttc
      901 tgaaatggtt acagaattat ctacaggaat tacaacattc ttatttaatg tagtagcttt
      961 aaaattagca ggagaaaatg gacttgctgc tcttactata gtattgtatg ctcatttttt
     1021 aatgacatca gtctatctag gattcgctgc tggagtgtct ccattaataa gctataattt
     1081 tggtgctgaa aacagtgata aattaaaaga aacatttaaa cattctctaa aatttatatt
     1141 tgtttcttct cttttagtgt ttattattgc tttagtattt gcaccattta ttgttagggt
     1201 ctttgtaagt ccagataaca cagtatttaa actagcctta caaggattaa aaatatttgc
     1261 atttgctttt ttgtttgttg gtataaatat atttgcatca ggatttttta cagcatttca
     1321 caatggaaaa atttcagcta ttatatcttt tagtcgtgcc tttgttttta taatcatagg
     1381 aatcataatt cttcctccta tgttaaacat gactggatta tggcttacag ttccatttgc
     1441 tgaggttata accatattta tatctattct atttataaaa aaatataaat gtagatataa
     1501 gtattaaaaa ttaatactta aaatcaacat ttattaaaac taataaacct gctttaaaat
     1561 acaaatttac aaatttgatt tttaagcagg ttttatttta gttataataa gtcatttgca
     1621 tactctttaa ttggtgcttt tctaagtaat aaaattataa atattatgca aataactata
     1681 attcctacct ttgttccaaa taaaataaaa ggattctgaa atgaataaat aattttttct
     1741 aaatacaata gcattttatg catattttta gttgcaaaat taactatata aattatcatt
     1801 aatatcggta atcctatcaa tatagtaata ctagtaactt ttctaactct atatgtaaaa
     1861 gctccaagta acactcctat aaaacctata catatttcat ttatacatat ttgtacaaaa
     1921 taatttaaat aagttagtgg catacttgat gttgaaggat ctatcagtgc tgatatagat
     1981 gtccaaatca tatctctctt tagtaaaact gatagttcta tactgtaacc tgttataatt
     2041 tctataaata acttcgataa aaaaatcaaa actataccta aaatagaaat cacaaagctt
     2101 aaaataatta aatctatgac aatagctttt atacaacttt ttctatctgc tcttatactt
     2161 aaagctcctg aaaagtcttt atttgctata tttactccat acacaaatag cagtatagtt
     2221 atatatgtta aaataggatt cacaatcgtg gataaattag ttttagatgc ttctccaaaa
     2281 atcttgagaa taaacactgg caaaatattc ataacaattc ccacaatcat aaatataatt
     2341 atatacaatt tagtattttt attaaaaaat tttatatatg gctttaattc attcaattac
     2401 aattcctcct tcttagtcat gttaacaaac atatcttgta gccctatgta tcctacatca
     2461 atatttgaat ttttaagtat tttttcatca ttttcactaa aatcaccata gtaaaaataa
     2521 gcgactgcat ttccaaatgc ctttttaggt tttatatttt ttatacattc taatttttct
     2581 aactcttctt tatttccagt aatataatga gctttttgtt ttatgacatc aatttcttca
     2641 tctataataa tttttccctc atttaatatt attacatgct ccagtaaatc atctatttca
     2701 tcaatcaaat gagttgatat tattattgtc cttggatttt ttatataact atctaaaatt
     2761 atgttataaa actcttgtct atttactgca tccagaccaa ttgttggctc atcaaatatg
     2821 gtgatagctg aattagaaca aatacctatt atatttgaaa gtatagtttt catacctctt
     2881 gacagttgtt tatacttttt tttagtattt aaatcaaaat atttgcataa ttcttcttct
     2941 aagcctttat cataactttt ataaaaacta gaagaaaatt caaatatctg acctacttta
     3001 aaatctggac tataaaattc tttttccctg acgatacaaa cttcttccaa aacttttata
     3061 tcttcttttg ggttctttcc taatatttct atctcacctt cattttgaat taactgattt
     3121 accattatat ttaataatgt tgtttttcca gctccattct tacctaataa accatatatc
     3181 ttattttttt caaagtttag agacatatta ttaaaaatat tttgcttctt aaaactgtga
     3241 gataaatttt ctatcttaat agaactactc atatattaat cctccttgaa attaattata
     3301 atatcaacca attcttctct atttatttct aatttgttag cttcttgaag taggtttttt
     3361 acaaaattat gtttaaaatt ttcttttcta gcttctttta taatagtttt tgcaccatct
     3421 gatacaaaca tccctatccc cctcttctta tataaaatat ttttatcaac caatatattt
     3481 atacctttta atactgtagc tggattaatt ttataaagct ttgaaagctc tgttgttgat
     3541 ggaacctgtt cttcttcttt tattccattt gatagtatct catcttcaat tgctcgtgct
     3601 atctgaataa atataggttc ttcattattt aatactaatt tcataggttc ctcctttctt
     3661 catcagttag ttactcaact aattaactat ataacttata atatcttgaa aaatattttc
     3721 tgtcaatact aaataaaaaa cagagggaaa attccctctg ttttttgttc tttatattta
     3781 taattaaatt ttgatttttg taatcctatc ccataagtta aaaattttaa taatctgttg
     3841 tatcttcatt ttttaatatt ttacatattg agctagttcc taacctttct gctcctgcct
     3901 ctataaattt ttctgcatca gaaattgatt taactccccc tgcagctttt atttttacat
     3961 tttttccaac atgctctttc ataagcttta tatcttctaa agtagctcca cctgttccca
     4021 ttccagtaga tgtttttata aaatctgaac ctgacattgt tactatttca cacattttta
     4081 ttttttcatc ttcatctaaa taacatgtct ctataatgac ttttaatact ttatctccta
     4141 tagctttttt tatttctttt atttcttttc ctatattatc ataatcttta ttttttatat
     4201 ctgaaatgtt tacaaccata tcaacttcat ctgctccatt ttcaatagca tcttttgctt
     4261 caaatacttt tgtagcagta gtttgatatc ccaaagggaa ccctatcact gtacatatct
     4321 ttattttacc ttttagatat tctgatgctc ttttcacata tgatggtggt atgcaaactg
     4381 atgctacact catatctaca gcttcatcac ataaaatttt aatatcttcc catgtagttg
     4441 tagcttttaa aatagtatgg tctactgttt ttaatatatg tttcataaaa tcctcctaaa
     4501 tttataatta atataattag attacttttt taaatgcaat tttctctttg caatattcag
     4561 tatcatatca acctcttcaa ctttaaaaat agtcattagt agtgtataaa ttccacctcc
     4621 aactataact gaaatagcta gtgatacaaa ctcattaaat gttcctactc ccaaaattcc
     4681 aaatataaat ttatacgtaa agtatgataa aacacccata attaaagatg caactaccga
     4741 tttcaaagtt gcttttatta ttttatcttg tccaaaatat ccaacttttc tctttaggtt
     4801 caagaagagt aacaatatac atgcaattga tgatgaacta gttgcaagag caagaccacc
     4861 atgagccatt ggttttatta aaactaagtc caatactata tttaccccta cagatataat
     4921 cccatttacc ataggtgttt ttgtgtcttg taatgaataa aaaacctttc ccaaaatatc
     4981 tcttaagcca aatgcagtca taccaactgc ataaaaaatt aaggcagttg ctgtcatttg
     5041 ggttgccctc gcatcaaaag cacctctctc aaaaatgatt ctaacaacag gagttgcaaa
     5101 aaaaatagaa gcaactgaaa taggaatcat agaaattatt atcatattta tactggattt
     5161 aactgaacta gtaaacttct tttgattatt ttctgcactt aacttagata acataggata
     5221 cataacagat actattgaag ctgtaaatgt ccctgtaaca aaaccattta atctatctgc
     5281 ataagtaagt gctggaatgc ttcctttaac taatgttgag gctaaagttg tatctaccaa
     5341 tgagttcact tgattaacag caacacctat aaatactggt gaaagtaatg ctagtaattt
     5401 aataaggcta tcatctttaa agtttaagta gtataagtat ttgtagttcg tttttttaac
     5461 aaaaaacatg taaaagagca gttgaactac catagcaacc acagcaccaa ttggaagtat
     5521 gtatggtcca aatacggtac ttaacattat tgaaataatt attactatat tatagggtat
     5581 acttccaaat ccaactacaa taaagttctc tttaatttgt aaaaatgctg acataacact
     5641 cgtaatacct atgaatatta ttcctg
//
LOCUS       DAEQCW010000165         5619 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.166, whole genome shotgun sequence.
ACCESSION   DAEQCW010000165 DAEQCW010000000
VERSION     DAEQCW010000165.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5619)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5619)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5619
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.166"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     regulatory      41..143
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            237..1613
                     /locus_tag="KRO40_003388"
     CDS             237..1613
                     /locus_tag="KRO40_003388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBH2094184.1"
                     /translation="MQTTNSSTMQKLFPILTNKNVDMKKEIIAGVTTFLTMAYIIAVN
                     PNILSETGMPAGALVTGTCLAAAFGCILMGVVANLPFALASGMGLNAFFAYTVVLQMG
                     VPWEVALTAVFVEGIIFIVLSVSGVREAVVNAIPKNMKLAVTGGIGIFIALIGLVNSG
                     IVIGDQATLIKMGRFTPAVIITCVGLIIIAVLDKKRVKGSILFGIVVSSLLAWAFAFI
                     NPEYAQKLGIYLPGGLFKFESLAPIAGKIDLGYVLHPTNIGGFLVVVCTFLFVDFFDT
                     VGTLVGVCSKANMLDEKGNVPNVGRALLTDAVATTVGAGLGVSTVTTYVESSTGVIAG
                     GRTGWTAITVGILFLAAMFFSPVFIAIPSCATAPALIYVGYLMLGTVKDIEFDNITEG
                     VPAFVTIACMALTYSIGDGLTLGILTYVFVNIFYNIFGAKKAEDKKHVSVVMIVLAIL
                     FIIKLWLL"
     gene            complement(1727..2872)
                     /locus_tag="KRO40_003389"
     CDS             complement(1727..2872)
                     /locus_tag="KRO40_003389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBH2094185.1"
                     /translation="MNTFEQLKISSTLIDGLKKQDITSPTEVQSLVIGNIIQNKDLLI
                     NSQTGTGKTLAYLLPIFEKIDTSKRETQALILAPTHELVMQITNQVELLAKNAELSVT
                     SLALIGEVNIQKQIKNIKAVKPHIVIGSCGRVLDLIKQKKLKSHNIKTIVLDEVDNLL
                     NGKNITCIEDIIRTTLRDRQIIGCSASLTDSTIKICDKLMKEFEIIKTKEKSQINPNI
                     NHSYLLGEIRDKFTFLRKALAATNPKKAIVFVNNEKNIEVIVSKLNYHNYKAIGIFGN
                     MEKEDRKNAINKFKLGKAKILITTDLSARGLDIVDVSHVFNLDFPKSKNEYLHRCGRT
                     ARGNRSGNTISIITKKELDIIKDLQKEFNIVITPKTLQNGELIDIIK"
     gene            3125..3832
                     /locus_tag="KRO40_003390"
     CDS             3125..3832
                     /locus_tag="KRO40_003390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094186.1"
                     /translation="MLKVINVSKSYKNKKVVSSVSFDVNDGELFGFIGHNGAGKTTTI
                     KAIVGIHDFEEGEVLINSKSIKKQPVECKKEMAYIPDNPDLYESLTGIQYLNFIADIF
                     EVAKDKREELIKYYSNKFELNKALGDLISSYSHGMKQKLAIISALIHSPKILILDEPF
                     VGLDPKASFILKEIMREFCDKGGCIFFSTHVLEVAEKICDKIAIIKDGNIIAYGTTEE
                     VKGSNSLESIFMELIEK"
     gene            3879..5474
                     /locus_tag="KRO40_003391"
     CDS             3879..5474
                     /locus_tag="KRO40_003391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094187.1"
                     /translation="MSNLSILIKNNIINEFKLNALKKADGREKQKIMGMMLSVVIIAG
                     LLIFYVTSLSLSLVDILKQINQLEMLLIFGFGLSTLTTIVTSLYKTSSYLFQAKDLDL
                     LTSLPIKESTVLASKILMLVGANYLFSSICMIIPAVVYFLNSDVSITYFPYLILLFLA
                     LPLLPIVASSIIFLFIGQISSRIKYKNLVLIIGSIILMLLYTLLMSRLNSMSVEMLKN
                     SVSISETIRKVYPPIYYFVDALKTGSIVSFLAFIAISIIPFFMFVTLFAKKFKDINAK
                     MSEGYKSKNYEFKGQKTSRPSKALLKKEFKRYTSSFIYFLNSSAGLLFLIVGTILILL
                     FGADKVGELLKLNIDFNLIKIQLLGVFFFIIVMNCTTYCSISLEGKNLWILKSSPIDE
                     REIFWSKILMNFLLNAPLSILCLILVSIRLDFEIQFIIVSICLIGSFSMFVALMGLLS
                     NLLYPNLDWKNEVAVVKRSASMIVTMLVSLAYVIILGGIYVLLGISFLNIYIILASIL
                     TLILDFMIWRIISTKGVKIFKNL"
BASE COUNT         1911 a          654 c          881 g         2173 t
ORIGIN      
        1 aaattaatta tataaattaa aataatattc gtaaagaaaa attcatgttt tgtactgtat
       61 aacatataat tttgacaata tgggtcataa gtttctaccg gaataccgta aatattctga
      121 ctatgtatac tattatttag ttaattaaat atttaattaa ctgaattatg aaggatacgg
      181 ctcagcttat caactactgt gtcgtttttt tgtaaaattt aataggaggt gttgttatgc
      241 aaacaacaaa cagtagtact atgcagaaac tttttccaat tttgactaat aaaaatgtcg
      301 acatgaagaa ggaaataatt gcaggagtaa ctactttttt aactatggct tatataatag
      361 ctgtaaatcc aaatatttta tctgagacag gcatgcctgc aggtgcactt gttacaggta
      421 cttgtttagc agcagcattt ggatgtattt taatgggtgt agttgctaac cttccttttg
      481 ctttagcatc aggtatgggt cttaatgcat tttttgcata tacagtagtt ttacaaatgg
      541 gtgttccttg ggaagtagct cttacagcag tatttgtaga aggtattatt tttatagtat
      601 tatcagtaag tggagttcgt gaggctgttg taaatgcgat accaaaaaat atgaaattag
      661 ctgttacagg tggtatagga atatttattg cacttatagg tctagttaac agtggaattg
      721 ttattggaga ccaagccact cttatcaaaa tgggtagatt tacaccagca gtaataataa
      781 cttgtgtagg attaataatt attgctgtat tagataaaaa aagagttaaa ggttctatac
      841 tttttggaat agtagtgagt tcattacttg cttgggcatt tgcttttata aatccagagt
      901 atgcacaaaa attaggtata tatttacctg gtggattatt taaattcgaa agtttagcac
      961 caatagcagg taaaatagat ttaggatatg tactacatcc aacaaatata ggtggttttt
     1021 tagtagtagt ttgtacattt ttatttgttg atttttttga tacagtaggt acattagttg
     1081 gtgtttgttc taaagcaaac atgttagatg aaaaagggaa tgttcctaat gtaggtagag
     1141 ccttacttac agatgcggtt gcaactacag ttggtgcagg acttggagta tctacagtta
     1201 caacttatgt tgagagttca acaggagtta tcgcaggtgg aagaactgga tggacagcaa
     1261 taacagttgg aattttattc ttagctgcaa tgtttttctc tcctgtattt atagcaattc
     1321 catcatgtgc tacagcacca gctttaatat atgttggata tttaatgctt ggtacagtta
     1381 aggatataga gtttgataat ataactgaag gtgttccagc ttttgttact attgcttgta
     1441 tggcattaac atatagtata ggtgatggtt taactttagg tatattaact tatgttttcg
     1501 taaatatatt ttataatata tttggagcta aaaaggcaga agacaaaaaa catgtttctg
     1561 tagtaatgat tgttctggca atattattta taataaaact ttggctacta taataggtat
     1621 tatttaaaat tttaatttaa tataaaataa agggctgtaa tttattatca attgtgatga
     1681 taaactacag ctcttttgta tttgttgtat ttttgtattt attgtattat ttaataatgt
     1741 ctattagttc tccattttgt aaagttttag gtgtaattac tatattgaac tctttttgca
     1801 aatcttttat aatatctaat tctttttttg ttattattga gattgtgtta ccacttcgat
     1861 ttcctctagc agttcgacca catctatgca ggtattcatt tttacttttt ggaaaatcca
     1921 agttaaaaac atgacttaca tccacaatat ctagtccacg agcagataaa tcagttgtaa
     1981 ttaaaatctt tgctttacca agtttaaatt tatttattgc attctttcta tcttcttttt
     2041 ccatatttcc aaaaattcct attgctttgt aattatgata atttagtttt gatactatga
     2101 cttctatatt tttttcatta tttacaaata caatagcttt ttttggattt gtagccgcta
     2161 atgcctttct aagaaaagta aatttatccc ttatctcacc taataaatat gagtgattga
     2221 tgttaggatt tatttgtgat ttttcctttg tttttattat ttcaaactcc ttcataagtt
     2281 tatcacaaat ttttatagtg ctatcagtaa gacttgcaga gcatcctata atttgtctat
     2341 ctcttaacgt tgttcttatt atgtcttcta tacaagttat attttttcca ttcaatagat
     2401 tgtccacttc atctaagaca atagttttta tattatgtga ttttagcttc ttttgtttta
     2461 tcaaatctaa aactcttcca caagagccaa ttactatgtg tggttttact gcttttatat
     2521 tttttatttg tttttgtata ttgacctccc caattaaagc taaagaagta acggagagtt
     2581 ctgcattttt agccaataat tcaacctggt ttgtaatctg cattactaat tcatgcgtag
     2641 gtgcaagtat aagagcttgt gtttctcttt ttgatgtatc aattttttca aatataggta
     2701 aaaggtatgc tagtgttttt cctgttccag tctgtgaatt aatcaataaa tccttatttt
     2761 gaattatatt ccctataaca agtgactgaa cttctgttgg agaagttatg tcttgttttt
     2821 tgagtccatc tattagagtg gaacttattt ttaattgttc aaatgtattc atattttact
     2881 ccttatattt taataattat agtcaactat tttttattat acattgttta ttcaaatcga
     2941 actatatatt cttttataat tatgtgtaat ttgaaagtaa atatcaatta tatttatacc
     3001 tttatatttc tgataccttt gcattttata gatttctaaa ataaacaaat aaaagttgta
     3061 attgtttgat atttgttata tattatatat aacaaatatc aaaactataa tatggaggga
     3121 aattatgtta aaagtaatca atgtatctaa atcatataaa aataaaaaag tagtaagtag
     3181 tgtctcattt gatgtaaatg atggagagct ttttgggttt ataggacata atggagcagg
     3241 taaaactact actattaaag caattgttgg aatacacgat tttgaagagg gagaggtact
     3301 aataaattct aaatctataa aaaaacagcc tgttgaatgt aaaaaggaaa tggcatatat
     3361 acctgataat ccagatttat acgagtcatt aactggtata caatacctta attttatagc
     3421 tgacatattt gaagttgcca aagataaaag agaagagtta ataaaatatt attcaaataa
     3481 gtttgaactc aataaagcat taggagattt aatatcttca tattcacatg gtatgaaaca
     3541 aaaattagct ataatttcgg ctttgataca cagcccaaaa atcttaattc ttgatgaacc
     3601 ttttgtaggt cttgacccaa aagcttcctt tatattgaag gaaattatga gggagttttg
     3661 tgacaaaggt ggttgtatat ttttctcaac acacgtttta gaagttgctg aaaaaatttg
     3721 tgataagatt gccataataa aagatggaaa tataattgct tatggaacta cagaagaagt
     3781 taagggaagt aattcacttg aaagtatttt catggaatta atagagaaat aaaatgtttt
     3841 ttatacaata tagtgtctaa agtgaggaat gataaaatat gagcaatcta agtatattaa
     3901 taaaaaataa tataataaat gaatttaaat taaatgcgtt aaaaaaagct gatggtagag
     3961 aaaaacaaaa aataatggga atgatgcttt cagttgttat aatagcgggt ctattaattt
     4021 tttatgtaac gagcttaagt ctctctttag ttgatatctt aaagcaaata aatcaactgg
     4081 aaatgctact gatatttggt tttggattat caacattaac aactattgtt acatcattat
     4141 ataaaacgtc atcatatcta tttcaagcaa aagatttaga ccttttgact agtttaccta
     4201 taaaagaatc tactgtacta gcaagtaaga tattaatgtt ggttggagca aactatttat
     4261 tttcttcaat atgtatgatt atacctgcag tggtttactt tttaaattct gatgtaagta
     4321 taacttattt cccttatttg atattgctat ttttagcttt accattatta ccgatagttg
     4381 cttcatcaat aatttttcta tttatagggc agatatcatc aagaataaaa tacaaaaatt
     4441 tagtattaat cataggtagc attatattga tgttgcttta taccctactt atgtcaagac
     4501 ttaattctat gtcagttgaa atgctaaaga atagtgtgtc tatttcagag acgattagaa
     4561 aagtatatcc tcctatatat tattttgttg atgctcttaa aacaggaagt atagtttcat
     4621 ttttagcatt tatagccatc tcaataatac cattttttat gtttgtaact ctgtttgcaa
     4681 aaaaatttaa agatataaat gctaagatga gtgaaggata taagtcaaaa aattatgaat
     4741 ttaagggtca aaaaacttca agaccttcaa aagctttatt aaaaaaagaa tttaagagat
     4801 atacttcttc gtttatatac tttttaaatt catctgcagg tttgttattt ctaatagtag
     4861 gtacaatttt aatattatta tttggagcag ataaagtggg tgagttactg aaattgaata
     4921 tagattttaa tcttataaaa atacaattat tgggagtatt cttctttata atagtaatga
     4981 attgtacaac atactgttca atttctcttg aaggaaaaaa cttatggata ctgaaatctt
     5041 ctccaataga tgaaagagaa atattctggt caaaaatatt gatgaatttt ttattgaatg
     5101 caccactatc tattttatgt ctaatattag tatctataag attagacttt gaaattcagt
     5161 ttattattgt atcaatctgt ttgattggaa gtttttcaat gtttgtagca ttgatgggat
     5221 tattatcaaa tttattatac ccaaaccttg attggaaaaa tgaggtggct gtagtaaaaa
     5281 gaagtgcaag tatgatagtt acaatgttag tatcattagc ttatgtaatt atacttggag
     5341 gtatatatgt attacttgga atttcgtttt taaatatata tattattttg gcaagtatac
     5401 ttactttgat attagatttt atgatatgga gaattatttc tactaaagga gtaaaaatat
     5461 ttaaaaattt ataagtgtat ttatgtcaaa taaagactta tcttttttag tcttgcaaat
     5521 aataggttaa gtagtatact atgtatagtg atatgaaaaa atttaggaga aaataaatga
     5581 gaaaattatc caaaagagaa aaagatttta ttcaatatg
//
LOCUS       DAEQCW010000166         5481 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.167, whole genome shotgun sequence.
ACCESSION   DAEQCW010000166 DAEQCW010000000
VERSION     DAEQCW010000166.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5481)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5481)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5481
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.167"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     repeat_region   4..953
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=4..32
                     /rpt_unit_seq="gttttagattaactatatggaatgtaaat"
     gene            1144..1296
                     /locus_tag="KRO40_003392"
     CDS             1144..1296
                     /locus_tag="KRO40_003392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094188.1"
                     /translation="MKNRRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDE
                     ELEQKE"
     gene            1417..2230
                     /locus_tag="KRO40_003393"
                     /pseudo
     CDS             1417..2230
                     /locus_tag="KRO40_003393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888845.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="toxin Bro"
     gene            2282..2443
                     /locus_tag="KRO40_003394"
     CDS             2282..2443
                     /locus_tag="KRO40_003394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094189.1"
                     /translation="MCENLLDNMYIEKRKEEYRIKLLKIRETDIDIYNKLESIVYKLS
                     EKKLEKNNK"
     gene            complement(2772..3236)
                     /locus_tag="KRO40_003395"
     CDS             complement(2772..3236)
                     /locus_tag="KRO40_003395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094190.1"
                     /translation="MDFGEVKSELSDKDLKDNEEALNKYKKYYLKVYKYYSEMDSIKS
                     IQDIEIEQSRLKGQLQKNSNPIFALYISIMAVVFSTTINLTFDLSDITNYFIRMIMTL
                     LFIVLLIFLVNKGILPIAIPYRNNIQFYTTALDVLEDMKKKILRERKYKKRR"
     gene            complement(3372..3689)
                     /locus_tag="KRO40_003396"
     CDS             complement(3372..3689)
                     /locus_tag="KRO40_003396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094191.1"
                     /translation="MDFGNINLILIGIIVIIGTTIIYLIKPKTAFCSKKYFNKLESIY
                     GNIDKKKTVKLEVLYRYVTGLEYIAIGLFTRRLDITILAIILVAIITTALYYLIRKKY
                     ITI"
     gene            complement(4067..4267)
                     /locus_tag="KRO40_003397"
     CDS             complement(4067..4267)
                     /locus_tag="KRO40_003397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094192.1"
                     /translation="MYFKTYILKREVNNKQLEITRSFDLDNLICTATEILEDIEIDLI
                     IIDEKNNVVWRNEKNTPAHENA"
     gene            complement(4286..4699)
                     /locus_tag="KRO40_003398"
     CDS             complement(4286..4699)
                     /locus_tag="KRO40_003398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094193.1"
                     /translation="MKVKSKRSFIVGIIVCMLCCASLVIYCILKDKRFLISSFLLIVI
                     AIFNFCNAFSRKGIVEELHDSADERDLYLTMKTSHILVKIMNYTLFTFTFLFIIAYSA
                     WKNQSLLVIAITLCVIEIFLFVAYLLINIFLEKKE"
     gene            complement(4683..4916)
                     /locus_tag="KRO40_003399"
     CDS             complement(4683..4916)
                     /locus_tag="KRO40_003399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094194.1"
                     /translation="MKTKVREFRTNMGLTQQQLADLVHVSNRTIISIEKEQYSPSLML
                     AYRMAQVFGTTIEELCCLKENKEMEDKKHESKE"
     gene            5135..>5481
                     /locus_tag="KRO40_003400"
     CDS             5135..>5481
                     /locus_tag="KRO40_003400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2094195.1"
                     /translation="MKISKLPEAELKVMRYICEANKVLTSRELVAAMEEKYEWNESTT
                     FTVLKRLERREFLSTEKIGKLTHYNILVKEKKYLRFETKEFLKNIHKNSISSLMSALH
                     GEDDEVDEDKLSEL"
BASE COUNT         2157 a          628 c          816 g         1880 t
ORIGIN      
        1 atagttttag attaactata tggaatgtaa atattacatt taatttgcat tgctttgatg
       61 acttctttgt tttagattaa ctatatggaa tgtaaatatt tttcaatatc aatatagaac
      121 tttcatcttt cccgttttag attaactata tggaatgtaa atcaagatat ttttaataaa
      181 atttctgagc gaactgtttg ttttagatta actatatgga atgtaaatga ggagattcag
      241 acagcgacta aaaagactga tataaagttt tagattaact atatggaatg taaataactt
      301 tatatctcca tttgcatatc catctgatga acgttttaga ttaactatat ggaatgtaaa
      361 tgcgtacaag gttgagaagc tccgcaatct caacgtcgtg ttttagatta actatatgga
      421 atgtaaatat ttgaaaggaa taaattttaa atgaatgaaa ggataggttt tagattaact
      481 atatggaatg taaatcagcc aaaaacttcg aatttgaact aaaatgcgtg ggttttagat
      541 taactatatg gaatgtaaat tctcatgact attgaataaa tataataaac aagcatacgt
      601 tttagattaa ctatatggaa tgtaaattta gaatcaaaag cacttaatcc tagttctttc
      661 atagttttag attaactata tggaatgtaa atagcttttt agcttcgtct actactttat
      721 aagcaaagcg ttttagatta actatatgga atgtaaatga tgaacaataa aacaatcatc
      781 taaagacgaa gaaagtttta gattaactat atggaatgta aatgttcctg ttgtgttttt
      841 tactaatccc attttatatg ttttagatta actatatgga atgtaaattg ctgtgatttc
      901 actaataaaa caattaataa ttgtgtttta gattaattat gtggattcaa aattaaataa
      961 acaaagaaag cacttacaaa tatgtaggtg cttttattct gttcaaaatt ggtcggttgg
     1021 gtaaaataat tagaaaaaat tagtaaaaac ctcttttctg taactcgtta caatattatt
     1081 attaatgtaa cgagttacag aaaagaggtg aataaaatag caactaaaag tagggcagag
     1141 tatatgaaaa atcgtcgaaa agataaaaga ggttttagtg tacttttaga caaagaaaag
     1201 ttagataaat ttgatgaagt attagaggaa aagaatctaa ccaagaaaga atggctagaa
     1261 gaaaaaatcg acgaggaact ggaacaaaag gaataaaaaa taagggtcac tcccaccgac
     1321 caaagtttga gtaaccccta tgacgtatac tatcatatat caattatagt atatgtcatt
     1381 ccttaaaaaa aatcaattat taaggagtgt aatattatga aaaatgaatt aatgatgttt
     1441 gaaggaaaag agattgaagt atttgaattt gaaggaagaa ttttattcaa ctcaaaagat
     1501 gtagcaaact gtttagacat aaaaaatgtt aatgagaata taagacttat gaataaaaag
     1561 caagttgtaa agttaagaaa ttcggatatc agtaatactg acatccgaaa acttaataat
     1621 gctggagaaa attttcttac tgaaagtgga gtgtataaat taatctttaa atcaagaaaa
     1681 gaagaagctg agagattcca agactggata agtgatgaag ttttaccaag cataagacaa
     1741 actggtgcat acataactaa taatgcaatc ccgaaaagtt gagagaaaaa gcaagtgaga
     1801 ttgaaaaatt acagttgctt ataacagtac atctatgtta aaagaattgt tagatgatgc
     1861 aggctttgac aataaatcaa aactattaac agctaaaaca ttatataaga aagcaggaat
     1921 tgatttacca atagagataa acgaagaaga acattatttt gatacaaaac aaatagcatc
     1981 taaactgaaa atatattcta agagtaataa accagctcag atggctgttt gtgagattat
     2041 taaaaagatt gatttagaag atggtgaagt taaaggtgtt tggtaaacta atggttcttg
     2101 gactggtact gtaaataaat atacaaagag tgtaatagat aaggtgagaa cttggataga
     2161 ggaaaataat agacctacca agattgcagg tgagaagaag aattatcatg tatcttacaa
     2221 aattgagtaa atttatcagt tgtattaaat aatttagttt agttttgggg ggattaatac
     2281 aatgtgtgag aatttacttg ataatatgta tattgaaaag agaaaagaag aatatagaat
     2341 taaacttttg aaaataagag aaacagatat agatatatat aataagttag aaagtatagt
     2401 atataaactt tctgagaaaa aattagagaa aaataataaa tagacatata aagcacttgg
     2461 atattctact gtttcaagtg ctttgtttgg tataaaatgg tataatggag atagagaatt
     2521 atattaaccc aaaaatggag aaaatagaga agatgattta gttgacgctt tatcagtagg
     2581 agtacttgca ggtaagacag aatctctagt actattagtt ggaaatggaa taagtgatac
     2641 tcaaaaaagt ttaataaata aaagagaatt tagaaatata actcaaattg gtggaaatgg
     2701 aaatgagaaa gcatttagtg aagtagaaaa cttagttaaa tagattagaa ggtagcaact
     2761 agagttggtt gttaccttct ttttttatac tttctctctc taagtatttt ctttttcata
     2821 tcttctaata catctaatgc agtagtataa aattgtatat tatttctata aggtatagct
     2881 attggaagaa tgcccttgtt aactaaaaaa ataagaagta caataaataa aagtgtcata
     2941 atcattctaa taaaataatt agtgatatct gataaatcaa atgttaagtt aattgttgta
     3001 gaaaatacaa cagccataat agatatatac aaagcaaaaa tggggttact atttttttgt
     3061 aactgtcctt taagcctaga ttgctctatt tctatatctt gaatactttt tatggaatcc
     3121 atttcactat aatacttata aacttttaaa taatattttt tatacttgtt taaagcttct
     3181 tcattatctt taaggtcttt gtcacttaac tctgatttaa cttccccaaa atccataaaa
     3241 tctctcctac aatgttatat agtatacttt aatttatagc atatttaaga acttatatca
     3301 gcaatttgtc gaacaatttt agctaaaaat agagtataat gataggctta ttatttataa
     3361 gatattattt tttatatagt tatatatttc tttctaatta gataatataa tgctgttgtt
     3421 ataatggcta ctaatattat tgctagtatt gtaatatcta atcttcttgt aaataagcct
     3481 attgctatat actcaagacc tgttacataa cgataaagta cttctagttt aacagttttt
     3541 ttcttatcta tatttccata tattgattct aatttattaa aatatttttt actacaaaaa
     3601 gcagttttag gtttaattaa atatattatt gtagttccta ttataactat tattccaata
     3661 agtataagat tgatatttcc aaaatccata gcagatacct cctattaaat ttgcttttct
     3721 tagtcaaagt atatcagtaa cacaagtaca aagagtatat aaaatattac aaatattaac
     3781 aggatagata aaactatagt aaaaattgta ataataaagc gaacgaaaat tatcatacta
     3841 aaacataaga catgttataa ttgtattaga tagaagatta acatacacca aagcactcct
     3901 tataataaag agtgcttatt tttttgaaat tcatcaatat ataaactatc aagaatctta
     3961 ttcaacacac cttaaaatcg atttaaatag ctctttttga tagcataatt tatatgatat
     4021 aataaaaaaa tagaagtgta ttcgcagtac acttctatag ttataactaa gcattctcat
     4081 gagcgggagt gtttttttca tttctccaaa caacattatt tttttcatca ataattatca
     4141 aatcaatttc aatatcttct aaaatttctg ttgcagtaca aattagatta tctaagtcaa
     4201 aacttcgagt tatctctagt tgtttgttat ttacttctct ttttagtata taagttttaa
     4261 aatacattta tatcacccct tgtatttact cttttttctc taaaaatata ttgataagta
     4321 aatatgcaac aaataaaaaa atctcaatga cacatagtgt tatagctata actagaagtg
     4381 attgattttt ccatgcacta taagctatga tgaaaagaaa tgtaaaagta aataatgtat
     4441 aattcataat tttaactaag atatgacttg ttttcattgt taagtacaag tctctttcat
     4501 ctgcactatc gtgtaattct tcaacaatgc cttttcttga aaaagcatta caaaaattaa
     4561 agattgctat tacaattaaa agaaatgatg aaattaggaa tcttttatct tttaaaatgc
     4621 aataaataac taaactagca caacataaca tacaaactat aatacccact ataaaacttc
     4681 gtttactctt tactttcatg ttttttatcc tccatttctt tattttcttt taaacaacat
     4741 agttcttcaa tcgttgtacc aaacacttgt gccatacgat aggcaagcat aagagaaggg
     4801 ctatattgct ctttttcaat agaaataatt gttctgtttg atacatggac taaatcagcg
     4861 agttgttgct gtgttagacc catatttgtt cgaaattctc gtacttttgt tttcattcca
     4921 taacctcttt ctatatgaag ctaacttcat gtgaagttaa cttcataata tcctaaaatg
     4981 agtaaaatgt caatctcatt agataagtat tataaaacct aaaagaataa tatggtaaaa
     5041 attggatgga attatttacc ttaattctct tgtttgtaaa actttattga tatagaattt
     5101 aacatataca taaatcggca aaggggtgcg aattatgaaa attagtaaat taccagaagc
     5161 ggaattaaaa gttatgagat atatttgtga agctaacaag gtattaactt ctagggaatt
     5221 agttgctgca atggaagaaa aatatgagtg gaatgaatca actacattta cagttttgaa
     5281 aagattagag cgaagggagt ttttaagtac agagaaaata ggcaaactta cacattataa
     5341 tatactagta aaagagaaaa aatatctaag gtttgaaaca aaggaatttt tgaagaacat
     5401 acataaaaat tcaatttcaa gtttaatgtc agcgttacat ggtgaagacg acgaagtgga
     5461 tgaagataaa ttaagtgaac t
//
LOCUS       DAEQCW010000167         5464 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.168, whole genome shotgun sequence.
ACCESSION   DAEQCW010000167 DAEQCW010000000
VERSION     DAEQCW010000167.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5464)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5464)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5464
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.168"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            420..725
                     /locus_tag="KRO40_003401"
     CDS             420..725
                     /locus_tag="KRO40_003401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094196.1"
                     /translation="MPSMIMEVVGVLFIAIGLILTFIEIKGNFPSFYGFGQNSIGKNA
                     VGIIAAGIALIFFRNGIDSIDSIATYGVFLAIELVVIVAYFLIRKKFTKEDKHLRTN"
     gene            1133..1822
                     /locus_tag="KRO40_003402"
     CDS             1133..1822
                     /locus_tag="KRO40_003402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094197.1"
                     /translation="MDILLVEDDKNIREMVYDFLISENYSVKTAIDGNTAIEIFKNYS
                     FDIILLDLMLPKSSGFEVLKYIRSVSVVPVIITTAKDSDTDKMLGLNLGADDYITKPF
                     SIVELLARIKANIRRATVYSSSRNSQDMVIQYKDLIINISKYVVSKNGIDLNLTHTEF
                     EIVKLLATNQGCAFSKEQLYNAIWKEPYYGNENVLNTHINRLRNKLSDGIEKNNYIKT
                     LWGIGYKMEEE"
     gene            1822..2739
                     /locus_tag="KRO40_003403"
     CDS             1822..2739
                     /locus_tag="KRO40_003403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2094198.1"
                     /translation="MELFLVVISIVLFALYLKERNKSKKMESDYKCINSRLRDITNDD
                     EINYILVPSDISIVKETAVDINKLLEKFYSRQINYNRSEKAILQIFTNISHDLRTPIT
                     VLKGYIEMLYLQSQKEELSSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
                     QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIK
                     YGSDGRFLGISLYEKEKHVFIDIEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAIS
                     QGLANSMGGSIYVNSRPNVKTVFTVKLKS"
     gene            2812..3738
                     /locus_tag="KRO40_003404"
     CDS             2812..3738
                     /locus_tag="KRO40_003404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094199.1"
                     /translation="MNYIIETHQLKKIYKDKAVVNAVNIHVKKGEIYGFVGPNGAGKS
                     TVMKMLLNLVKPNSGEIVMFSKKVEETDFEILKKIGTIIENPYLYENLTAKQNLDLHC
                     EYMGYYNKEHISEVLECVGLSKQSNKKVSKYSLGMKQRLAIARAILTKPELLILDEPI
                     NALDPEGIREMRELFRKLNTDYGITIFISSHILSEVEQIADTIGIIQDGKLIKEISMS
                     DIHKYQTDYVEVDVDNVELAGYLLEKEFGIKDFKITSESCIEIYDLRKDVKEISKIFI
                     QNQIGINSIGRKQSSLEDYFFQTTGTGGKETL"
     gene            3735..4415
                     /locus_tag="KRO40_003405"
     CDS             3735..4415
                     /locus_tag="KRO40_003405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094200.1"
                     /translation="MIHLMKLELKKVGLKRYFLFSMLGIFLCMFFVFTGLNDKSTSIY
                     DYDVTFRTISLFFCFYYIILFAVLNVAYIINEYTNKTILILFSYPLDRKKLILSKLLL
                     ITTLMISSMIVGYICCFTFVVVLDKYFNLVIGDFHISILSYWIPGAIKSIIIFCSLGI
                     WTFVVGMIRKSIPVTLVSSIIFINLRQFILAGTNTTQDSLISVFIIVGITVIGIYYIL
                     NHKVTEID"
     gene            4513..4848
                     /locus_tag="KRO40_003406"
                     /pseudo
     CDS             4513..4848
                     /locus_tag="KRO40_003406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427885.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
BASE COUNT         2124 a          569 c          843 g         1928 t
ORIGIN      
        1 caagcttata gattaaaaaa taaatgattt atagatgaag aactaaactc atagattaaa
       61 aaataaatga cttatagatg aaaaatcaag ctcatagatt aaagaataaa taacttatta
      121 gatgaaaaaa caagcttata gataagaagt ccatgcttat aagccagaaa atgaatactt
      181 taatagatta aaaaatacat atttgtgaat tatagaatga atgactccat aaactagaaa
      241 atttataata atatctatat gaaaattaga attattttat cacaaaaaaa ttaagttaaa
      301 taaatatgaa attacttcca aatatacttc caaaaacatg taatcgcata tataatataa
      361 ttataaaaat aataaatatt tttatagtag tagttaatta ttaataagga ggggtcaaaa
      421 tgcctagcat gattatggaa gttgtaggag tactatttat agctattgga ttaatcttga
      481 cattcattga aataaaagga aatttccctt ctttttatgg ttttggtcaa aattctatag
      541 ggaaaaatgc tgtaggtatt atagcagcag gaattgcttt aattttcttt agaaatggca
      601 tagatagcat agattctata gctacttatg gtgtattttt agcaatagaa cttgttgtaa
      661 tagttgcata tttcttaata agaaaaaaat ttactaaaga agataaacat ttaagaacta
      721 attaactaaa ttatctacta taaaattgga aaattaaaaa caaataaaag tttgttttta
      781 attatttaaa atccaaattt gattattttt aaagaaacta tgttctgtat aaaactagaa
      841 tgtggtttct tttttatgta taaaatattt tttagcaaaa gttaaaaggt gttttataat
      901 ataaaatagt taattgtaga tgttaataaa agaaaattat gtatatttca gataaagata
      961 agagagtata ctatatttta attctttttt caataaagct tattgaaaag aactttaact
     1021 tagaagagta tcaccaaatt gcagatacaa tatcataagc agttatttat tgacaaccct
     1081 ttttaataaa tatatcattt gaagtatact gacgaaaagg agttgaataa taatggacat
     1141 cttattggtt gaagatgata agaatattcg agaaatggta tacgattttc tgattagtga
     1201 gaattactct gttaaaactg ccattgatgg aaatacggct attgaaatat ttaaaaatta
     1261 ttcatttgat attattttac tggacttgat gttaccaaag tctagtggtt ttgaagtatt
     1321 aaaatatata cgaagtgtga gtgttgttcc tgttattatt actactgcga aagatagtga
     1381 cacagataaa atgctagggc ttaatcttgg tgcagatgat tatattacaa agcctttttc
     1441 aatcgtagaa ttgcttgcaa gaattaaagc taatattaga cgtgcaacag tgtacagcag
     1501 ttcaagaaac tctcaagata tggttattca gtataaagat ttgattataa acatatcaaa
     1561 atatgtagtt tcaaagaatg gaattgactt aaacttaaca catacagaat ttgaaattgt
     1621 taaattacta gcgactaatc aaggatgtgc tttttcaaag gaacaattat acaacgctat
     1681 ttggaaagaa ccttattatg gaaatgaaaa tgtgctaaat actcatatta acaggttaag
     1741 aaataaattg tctgatggta tagaaaaaaa taattatatt aaaactcttt ggggaattgg
     1801 ctacaaaatg gaggaagaat aatggagtta tttttagttg taatttcgat tgtactattt
     1861 gctctctact taaaagaacg aaataaatca aagaaaatgg aaagtgatta taagtgtatc
     1921 aattcaagac ttcgtgacat aacaaatgat gatgaaatta attatatttt agtaccatct
     1981 gatatttcga ttgtaaaaga aacagcagta gatataaata aacttcttga aaagttttac
     2041 agcaggcaaa ttaattataa tagaagtgaa aaagcgatat tgcaaatatt tacaaacata
     2101 tcacacgatt tacgaactcc catcacagta ttaaagggtt atattgaaat gctatatctt
     2161 caaagtcaaa aagaagaatt atcttcttca atgagagcaa ctgtggaaaa aatgcaaaca
     2221 aattcaaatg agcttgttaa ttcaataaat aacctgttta atatggcaaa aatccaatct
     2281 ggagatatga tattaaatct tcaaaaatcc aatctaacac aattatgtca tgagattatt
     2341 ttagagtttt atgatttgct agataaagaa aactttaatg ttgaagttaa tattgaagat
     2401 agacctatat atgcaaatgt tgacacagaa gcattacaac gtatactcaa aaatttaatt
     2461 gataatgcta taaaatatgg ttcagatggt agatttttag ggatttcact atatgaaaag
     2521 gaaaaacatg tttttataga tattgaggat aaaggttcag gtatttctga aactgaaaaa
     2581 gagcatattt tcacaagagc ttatactgct gacagaaaaa aaggcaatgg tttaggtttg
     2641 gctatttctc aagggcttgc aaactctatg ggaggttcaa tttatgtaaa tagtagacct
     2701 aatgtaaaaa cagtttttac ggtaaaattg aaaagttaga aaaaagttag atttaaaaga
     2761 gagaaaagac aattttattt tgtatactgt ttttagaaag gagggagtat gatgaactat
     2821 atcatagaga cccatcaatt aaagaaaata tataaagata aagctgttgt taatgctgtt
     2881 aatattcatg tgaaaaaggg agaaatttat ggatttgttg gaccaaacgg ggcaggtaaa
     2941 agtacagtaa tgaaaatgtt gctaaatctt gttaagccaa attctggaga aatagttatg
     3001 ttcagtaaga aagtggaaga aactgatttt gaaatattaa aaaagattgg tactattatt
     3061 gaaaatccgt atttatatga gaatttgact gctaaacaga atcttgattt acactgtgaa
     3121 tatatgggtt attataacaa agaacatata tcagaggtat tggaatgtgt cggattgtca
     3181 aagcaatcaa acaagaaagt ttcaaaatat tctttaggga tgaaacaacg tcttgcaata
     3241 gctagagcaa ttcttactaa accagaatta ttgattcttg atgaacctat aaatgcactc
     3301 gacccagagg ggataagaga aatgcgagaa ttattccgta agttaaatac agattatgga
     3361 ataactatat ttatttctag tcatattctt tcagaggtag aacaaattgc ggacactatt
     3421 ggaattattc aagatggtaa acttattaaa gaaatttcta tgtcagatat acacaaatat
     3481 caaacagatt atgttgaagt agatgtagat aatgtggagc ttgctggata cttgttagaa
     3541 aaagaatttg gaataaaaga ctttaaaatt acttcggaaa gttgtattga aatatatgat
     3601 ttacgaaaag atgtaaaaga aatatccaaa atatttattc aaaatcaaat tggtataaat
     3661 agcattggac gtaaacaaag ttctttagaa gattacttct tccaaactac aggtacagga
     3721 ggtaaagaaa cactatgata catttaatga aactagagct aaaaaaagtt gggctaaaaa
     3781 gatatttttt attttcaatg ctggggattt tcttatgtat gttttttgtc tttactggat
     3841 tgaatgataa atctacttca atatatgatt atgatgttac atttaggaca atcagtttat
     3901 ttttctgttt ttactatatt atattatttg ctgtgttgaa tgtggcatat ataataaatg
     3961 aatatacaaa taaaacaatc ttgattttat tctcttatcc acttgaccgt aaaaaactta
     4021 ttttatcaaa gttacttttg attacgactc ttatgatatc atcaatgata gttggatata
     4081 tctgttgttt tacattcgtt gttgtgttgg ataagtattt taatttagtt attggagatt
     4141 ttcatatttc aattttatct tattggatac caggagcaat taaaagtatt attatatttt
     4201 gctcattagg tatatggaca ttcgttgttg gaatgataag aaaatcaata cctgttaccc
     4261 ttgtcagttc aattattttt atcaatttaa gacaatttat tttagctggt acaaatacaa
     4321 ctcaagacag tttgatttct gtttttatta tagttggtat aactgtgatt ggtatatatt
     4381 atatactaaa tcataaagtt actgaaattg actagatact gtggctagga aggtagttat
     4441 taattgtatc ttcttgggat aataatgatt tgctattata tcagctatta ttaatattat
     4501 tagagtttta ataatattgc acaaccattt gaagttgagc caaagcttga tgaattaatt
     4561 gaatggtact atagtcagag tgaagtatct attaaagtta tagctgaatt tcattataga
     4621 tttgaattga tacatccatt tcaagatggt aatggtcaca taggtagatt tgttatgcta
     4681 aaacagatgt tagaaaataa tcttcctata aaaattgtat cttgggatag tgaggacttg
     4741 tatagaaact ccttaaattc ttgtagttta ggtaattatg tccctttaat tgaatattta
     4801 tcaagtttag aagattttag agaagtatat aaaatgttat ggaaataatt gtttgcagca
     4861 aaaaaaaatt ttatataaat atatttttat ctatgctatt taacgctaat ttcttagtta
     4921 ttcttagctt ggactatatc cactatttta actatataaa atagtggata tagtttaact
     4981 atctctttat aactattctt atgtatctta gttgtttctt aatatgggga cagttcataa
     5041 aactaaaagt gatttttaat tttatcattt ataatttacc attacatcag aaaaatgctt
     5101 atcattagaa ttttcataaa agtcacctat ttttttcaat taactaaatc aattctatta
     5161 gtcttaatct ttcgtatttc aaattgataa tataagaaaa taaaaaataa aaaattttaa
     5221 attttttatt tattgcgaaa aaaataaaaa ggtgctatac tttttgtaac atattattca
     5281 aattattaag agatagtaaa catttatagt ttaatttgta gtacactagc atgatttgca
     5341 gaacaatgaa ttaatctata gtataatagt ttaatttaaa gtacaacgat ttaatctata
     5401 gtacactagc atgatttgaa gtacaacgat ttaatctata gtacaataac ttgatttgca
     5461 atac
//
LOCUS       DAEQCW010000168         5404 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.169, whole genome shotgun sequence.
ACCESSION   DAEQCW010000168 DAEQCW010000000
VERSION     DAEQCW010000168.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5404)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5404)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5404
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.169"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(522..1928)
                     /locus_tag="KRO40_003407"
     CDS             complement(522..1928)
                     /locus_tag="KRO40_003407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBH2094201.1"
                     /translation="MDSVKYILRRFIGSSILISLLFIVLNIAGFLLFSYMLFVSKYSD
                     NLDTSDSREIKSNLIMIEDNLILRNGKFILDDSSKEVLHKNKVWAMLIDNNGDRIWGF
                     DLPKEIPSHYTLTDVAKFSRFFLKDYPVYVWEHPNGILVTGYPKDKYTKFNLTYTVKE
                     IEQFPMLIIGMFLVNAIVTFLIALFIGLKMVKSIKPIITGIKLMSKGEPVLLQEKGIL
                     SDISKSINTVSKELQMKDEKLRKKEEARSNWIAGISHDIRTPLSMIIGYAGELEESSS
                     LSNREQEQVSIICNQGIKIRELVNDLNLVSKLEYNMQTLNCDKIRVSAFLRELISEFI
                     NNNLDNDFYVELDILNEDIIIDADKKLLKRAISNLIQNSITHNQQGCNIRVTSKSDLD
                     FCYIIVEDDGKGMSQERINSLLKGQNGLSEAYAKGQNHGLGILIVSGIINAHRGKLDI
                     TSIDSQGLKTILKLPLIK"
     gene            complement(1973..2680)
                     /locus_tag="KRO40_003408"
     CDS             complement(1973..2680)
                     /locus_tag="KRO40_003408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094202.1"
                     /translation="MESIKDKKILVVDDHKELLKMIDEILRKEGFSRVFLASSYEEAV
                     RVFRNVKPDCAILDVVLPDGDGFSIMRKIRETSKIPVIFLSARGEDEDRLIGLGLGAD
                     DYIVKPFLPKELTLRLVGILNRVYVPIEEEELPVFKLGDSVVVNLNSACVEKDGQEIS
                     LTAKEHSLLLKLYENKGRIVTNDSLCQAIWGDDMYGYENTLMVHVRRVREKIEKTPST
                     PKHLITVRGLGYKLMIN"
     gene            2851..3765
                     /locus_tag="KRO40_003409"
     CDS             2851..3765
                     /locus_tag="KRO40_003409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094203.1"
                     /translation="MEMIIRTQRLSKEYNKIFRVKDIDLRVPQGAVYGFLGPNGAGKS
                     TTLKMLLGLAKPTQGNINILGKELNEKNRISILKDIGSLIESPSYYGHLTGLENMTIM
                     QRLLDLPEKNVNEALKIVRLENQKNKKVSQYSLGMKQRLGIAMAIMKFPKLLILDEPT
                     NGLDPAGIEEIRELIKSLPEKYGMTVLISSHLLSEIDQIATSIGIINHGELVFQDSIK
                     ELHNRGQSQIAIKTKNVVSAQKLLNTKGYMSLIQDGYLTIENLKDSDVAKINGMLVHS
                     NIDVFRIEEHKKSLEDIFLELTGKAVTL"
     gene            3765..4526
                     /locus_tag="KRO40_003410"
     CDS             3765..4526
                     /locus_tag="KRO40_003410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094204.1"
                     /translation="MKYLGLEFYKLKRKKIILMTFLFVAVEIMWCIINSNRAITRNPD
                     MLGGFEYSYMLMSFASLNGLFFPILISIITSRISDIEHKGDTWKLLKSSVTSLNSIYL
                     SKFLCSAILVSIPVLMQVLSIVLFGHFRGVIESISVSLLLKYTLGTILVSIAIIALHL
                     WIATVIPNQMIAITFGMIGSFIGLTSGLFYQGIRRLFIWSYYLELSPLSYAYDNVLGS
                     SVYRIDMNFSITILVFLIGMLIYYIGRNHLLKKEV"
     gene            4538..5275
                     /locus_tag="KRO40_003411"
     CDS             4538..5275
                     /locus_tag="KRO40_003411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094205.1"
                     /translation="MLRKSVLGEILKLKNSFIWYVLLALPLISVLIGSGNFYLNQGIL
                     KKEWYSLWTQVSLFYGEFFFPILIAIFCAYICRLEHMNHNWNNVMTLPVNLKNIFLSK
                     LTVVSILTAITQVFFVIFYIVAGNMFGFSGSVPKELTGWIAKGWIISISIASIQLYMS
                     IKIRSFATPIGISLCLSLFGMGLIVAKPAVGIFFPYSMLGSAMGVIKQSALNVNDTIV
                     TICVAFITTIVFSEIANRNFRKNDVIS"
BASE COUNT         1866 a          834 c          705 g         1999 t
ORIGIN      
        1 atactacaca aaaactctac tttagtagaa cttaatggcg caaaatactt caatttaaaa
       61 catttatcgt actttaaata aataactata ataatatact tacaatagtt acatagaagc
      121 tattataact acacagaaca gcgtataatt aaaacttttt taggatgtca ttatattttt
      181 tcttaaaatt aaaaaacact ataccataat tctattttag tagaattttt ttgtcaataa
      241 taaaattaaa tattaactaa aaaataaaaa aaatggaatt atctaaagaa tttaataacc
      301 ttacaataat tccaaaatat tatttctatg aaaattttga taccatgagt aactcagcca
      361 taagcgcata aagcacaagt tactctttac tttaataaaa cttgacaaga aaagaattta
      421 tccttattct actctaatag agttaatttg tcaataaaga ataaaattat tttcaaaata
      481 ttttcattct tcattcttat ctgttattat tttataaaat atcacttaat tagaggtaat
      541 tttagtattg tttttagtcc ctgactatca atgctcgtaa tatctaattt acctctatgt
      601 gcattaataa tgccagatac tatcaaaata cctagaccat gattttgacc tttggcatat
      661 gcctcactta gtccattttg gccctttaat aaactattaa ttctttcttg actcatacct
      721 tttccatcat cttcaacaat tatatagcaa aaatctaaat cagacttaga ggtaaccctt
      781 atattacatc cttgttggtt atgagttata ctattttgta ttaaattact aatagccctt
      841 tttaataatt ttttatctgc atctataata atatcttcat ttagtatatc aagttcaacg
      901 taaaagtcat tatccaaatt attatttata aactcagaaa taagctctct caaaaacgca
      961 gaaactctaa tcttatcaca attcaatgtt tgcatattat attcaagttt agacactaaa
     1021 ttgaggtcat ttactaattc tctgatttta atcccttgat tgcatataat agacacttgc
     1081 tcttgttctc tatttgaaag gctactgctt tcttcaagtt ctccagcata tccaattatc
     1141 attgaaagtg gagttcttat atcatgagat attcctgcaa tccagttaga cctagcttcc
     1201 tctttcttcc taagtttttc atctttcatt tgcaactctt tagatacagt attaatagat
     1261 tttgaaatat cacttagtat tcctttttct tgtaaaagta ctggttctcc ttttgacata
     1321 agctttatgc cagtaataat tggttttata gatttcacca tttttaaacc tatgaataga
     1381 gctattaaaa aagtaactat tgcattaacc agaaacatac ctattattaa cataggaaat
     1441 tgttctattt ccttaaccgt ataagtaagg ttaaacttag tgtacttgtc ttttggataa
     1501 cctgttacta atattccatt tggatgttcc catacataca caggatagtc ctttaaaaag
     1561 aaccttgaaa actttgctac atctgtcaaa gtataatgac ttggaatttc ttttggtaaa
     1621 tcaaatcccc atattctatc tccattgtta tcaattaaca ttgcccaaac tttattttta
     1681 tgtagtactt ccttactaga atcatctaaa ataaactttc catttcttaa aatcaaatta
     1741 tcttcaatca taatcaagtt tgattttatt tctctgctat cacttgtatc taaattatca
     1801 gagtatttag atacaaatag catatatgaa aacagaagaa aacctgctat atttaataca
     1861 ataaaaagta atgaaatcaa gatacttgaa cctataaatc gcctcaatat gtactttaca
     1921 ctatccaaaa ttaaatcact cctcttgatt tcttttattc taatatctaa aattaattaa
     1981 tcatcaactt atatccaaga cctcttactg taataagatg tttaggtgta gatggagttt
     2041 tttctatctt ctctctaact cttctaacat gaaccataag ggtattttca tatccataca
     2101 tatcatctcc ccaaatggct tgacatagtg aatcattagt aacaattctc cctttatttt
     2161 catacaactt taaaagcaac gaatgctctt tagctgttaa agaaatctct tgcccatctt
     2221 tctcaacaca tgcactattt aaattcacaa caacagaatc tcccagttta aatactggca
     2281 actcctcttc ttctataggc acatatacac gatttaatat acccacaagc cttaaagtaa
     2341 gttcctttgg taaaaatggc tttactatat aatcgtcagc ccctaagccc aaaccaatca
     2401 atctatcttc atcttcacct cttgcagaga gaaaaatcac tggtatttta gatgtctctc
     2461 taatttttct cataatagaa aaaccatctc catctggcaa tacaacatct aaaattgcac
     2521 aatctggctt tacatttcta aataccctaa cagcttcctc ataacttgat gctaaaaata
     2581 ctctactaaa cccctctttt ctcaggattt catctatcat ttttaataat tccttgtggt
     2641 catcaaccac aagtattttt ttatctttta ttgactccat aatcatcacc ctcctttagt
     2701 ataccatata cccattttca caactttgcc taaatagact tttaaggtta ttgtaaggta
     2761 aatttcagct aattgaaatg taaccaagtt attatactga tataagttaa aagaatcaat
     2821 aagcacagat taaaaaaggg gatgaaacat atggaaatga taattagaac acaaagactt
     2881 tcaaaggaat acaataaaat atttagagta aaggatatag acctaagagt tccacaagga
     2941 gctgtatatg gttttttggg tcctaatgga gctggaaaat ctaccactct taaaatgctt
     3001 cttggacttg ctaaacccac acaaggaaat attaatattt taggtaaaga gttaaatgaa
     3061 aaaaatagaa tatcaatttt aaaagatata ggttctttga tagaatctcc atcatactat
     3121 ggtcatctta cagggcttga aaacatgacc ataatgcaaa gactcttaga tttacctgaa
     3181 aaaaatgtaa atgaagcatt aaaaattgta aggttagaaa atcaaaaaaa taaaaaagtt
     3241 agtcaatatt ctttaggtat gaagcaacgt cttggcattg ctatggcaat aatgaagttt
     3301 cccaaattat taatacttga tgaacctaca aatggactcg acccagcagg gattgaggaa
     3361 attagagaat taataaaatc tctaccagaa aaatacggga tgactgttct aatctctagc
     3421 catcttttaa gtgaaattga ccaaattgcc acatcaatag gaataataaa tcatggcgaa
     3481 ctggtttttc aagatagcat aaaagaactt cataatagag gtcaaagtca gattgctatc
     3541 aaaactaaga atgttgtatc tgcacaaaaa ctattaaata ctaaaggata tatgtcactt
     3601 atacaagatg ggtacttgac tattgaaaat ttaaaagact cagatgtggc taaaataaat
     3661 ggtatgcttg tccattcaaa tatagatgta tttagaatag aagaacataa aaaaagcttg
     3721 gaagatatat tcttagaact tactggtaag gcggtgactt tataatgaaa taccttggtc
     3781 tagaatttta taaacttaaa agaaagaaga ttattctgat gaccttttta tttgtagctg
     3841 ttgaaataat gtggtgtatc ataaattcaa atagagctat tacacgtaat ccagatatgt
     3901 taggtggatt tgaatattcc tatatgctta tgagttttgc aagtttaaat ggtctattct
     3961 ttcctatctt aatatcaata attacatcac gtataagcga tatagaacat aaaggagata
     4021 catggaagct tttaaaatct tctgtgacat ctttaaatag tatttattta tctaaatttt
     4081 tatgttctgc tattttggta tctatacctg tattgatgca agtgctatct attgtgttgt
     4141 ttggacattt tagaggggtt attgagtcaa tttctgtatc tttactttta aaatacacat
     4201 taggaacaat tcttgtaagt attgctatca ttgcactaca cctatggatt gcaactgtaa
     4261 ttccaaatca aatgattgca attacatttg gcatgattgg tagttttata ggtttgacat
     4321 caggtttgtt ttatcaaggt attcgtagat tgtttatatg gtcttattac ctagagttat
     4381 cacctttaag ttatgcttat gataatgttt taggttcatc tgtctataga attgatatga
     4441 atttttctat tacgatttta gttttcttaa ttggaatgct aatttattat attggaagaa
     4501 atcatttatt aaaaaaagaa gtataggagg gatttaaatg ttaaggaagt cagttttggg
     4561 agaaattcta aagttaaaaa attcttttat atggtatgta ttattagctt tgccacttat
     4621 aagtgtgttg attggttctg gtaattttta tctaaatcaa ggcatactca aaaaagaatg
     4681 gtacagctta tggactcaag ttagtctttt ttatggggaa tttttctttc ctatcttaat
     4741 cgcaatcttt tgtgcatata tttgtaggct tgaacatatg aatcataatt ggaataatgt
     4801 aatgacactg ccagttaatt taaaaaatat ctttttatct aaacttacag tagtttcaat
     4861 acttacagct attacacaag ttttctttgt tatcttttat atagttgcag gaaatatgtt
     4921 tggtttttct ggtagtgtac ctaaagaatt gactggttgg attgctaaag gttggattat
     4981 ttctatttca atagcttcta tacaattata catgtctata aagattagaa gttttgcaac
     5041 tcctattggt attagtcttt gcctttctct atttggtatg ggattaatag tagcaaaacc
     5101 tgctgttggt atatttttcc cttattctat gttaggtagt gctatggggg ttataaagca
     5161 atctgcttta aatgttaatg acactatagt tacaatatgt gttgcattta ttactactat
     5221 agtattttct gaaattgcca atagaaattt tagaaagaat gatgttattt cttaatggta
     5281 aatgctagat attttggggt ttgaaattta tattcttttt agttgaaatc tatatccatt
     5341 ttatttaaaa atatatatct tttatttgaa ttttatatgt tttatctact cgctatataa
     5401 taga
//
LOCUS       DAEQCW010000169         5352 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.170, whole genome shotgun sequence.
ACCESSION   DAEQCW010000169 DAEQCW010000000
VERSION     DAEQCW010000169.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5352)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5352)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5352
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.170"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(204..1388)
                     /locus_tag="KRO40_003412"
     CDS             complement(204..1388)
                     /locus_tag="KRO40_003412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2094206.1"
                     /translation="MLSKRLNFITPSYTIGISSKVKEMESNGVKVINLSIGEPDFNVP
                     NNAKSYGIDSLNKDYTKYDLVPGLKILREEICKKLIEENNCNYSIDEIVVSSGAKNSI
                     TNTLLALTDEGDEVLLPKPYWVSYPEMVKLVNAVPVFIDTKKENGFKLTKDELEKSIT
                     DKTKILVINNPSNPTGSVYTKDELIEIVDVCIQNKIYILADEIYEKICYTGEFTSIAS
                     LSEEAKDITITINGFSKSAAMTGLRLGYTASNKTIAKAMSSIQGHLISHPSLTAQYIA
                     YGALKDCSIDIDNMVKTYKSRRDLIKSKLDSIDNVGYVNPNGAFYIFIDLSKVSEKFE
                     YKDSFSIEFCNQFLEEYNVAVVPGIAFGMDKYIRISYACSENTFLSGLDKLKEFVYKI
                     MA"
     gene            1761..4112
                     /locus_tag="KRO40_003413"
     CDS             1761..4112
                     /locus_tag="KRO40_003413"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside triphosphate reductase"
                     /protein_id="HBH2094207.1"
                     /translation="MVEFVKKRDGRVIPFNEDRITRAIFLAATNVAEREGIVPDYKLS
                     EQLTQEVIKFLNHKYSESVPSVEDIQDSVVKVLIETGHAKTSEEYIIYRTERSRIRNS
                     KTRLMKAIEEITFEDAEDADIKRENANINGNTAMGTMLQYGSTVSKEFCKTHILKPEH
                     SFAHDNGDIHIHDMDFLNMGTLTCCQIDVKKLFNGGFSTGHGFLREPQDIISYGALAA
                     IAIQSNQNDQHGGQSIPFFDYGLAEGVYKTFKKFYIGNLAKALKLFKGIENNDVIKNI
                     VYNTEKETNQKVGLKRDELYLNLEKEKLIQTFDIDDELVNKMQNFAFEESYRETDKKT
                     YQSMEAFIHNLNTMHSRAGAQVPFSSVNFGTDTSEEGRMVTKNLLLSQERGLGNGETP
                     IFPILIFKVKEGINLNPEDPNYDLFKLSCRVSAKRLFPNFSFLDAPFNAKYYKKGEPD
                     TEATYMGCRTRVLSNVCGSETVSGRGNISFTTVNLPRLGIKHGIINNEKANLDGFFEE
                     LDEKINLIIEQLLERLEVQGNKKMKNFPFLMGQGVWKGSDDLGPEDTLKEVIKQGTLT
                     IGFIGLAECLIALIGKHHGESKEAQELGLKIVSHMRHKMDEATDKYKLNFSLMGTPAE
                     GLSGRFTKIDKKVYGEIKGITDKEYYTNSFHVPVYYNISAYDKIEIEAPYHELTNAGH
                     ITYVELDGDPSDNLEAFETVIKAMKDLGIGYGSINHPVDRDPICGFSGVITSNICPVC
                     GRNEDESDIKFERIRRITGYLVGTVDRFNNAKKAEVRDRVKHR"
     gene            4134..4673
                     /gene="nrdG"
                     /locus_tag="KRO40_003414"
     CDS             4134..4673
                     /gene="nrdG"
                     /locus_tag="KRO40_003414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HBH2094208.1"
                     /translation="MKIRMSSTISYDSIVDGPGLRMVIWTQGCIHNCKECHNPQTHDL
                     CGGFYMDTEEIINKVKSLKLQKGITLSGGEPFLQPEPLEEIAREAKINGLDVWSYTGF
                     TFEQLLDKKNRAYFKNLNLLKQIDILVDGKFIAEKKDISLKFRGSSNQRIIDVQKSLK
                     YKKVFLVEQYMKDDLSIAE"
BASE COUNT         2096 a          598 c          852 g         1806 t
ORIGIN      
        1 ttataataaa tttagaattt aacttatata gtttaatttg ataatttgat gaaaaaaata
       61 aaagacttac tgatttttaa atctataggt cttttatttt ttatctaaca tttaaattaa
      121 gttgttgaat atatcttata ttacttacct tatatattaa ttaccattaa tacattatat
      181 ctaattacta ttcatctaaa ttattatgcc attattttat atacaaattc ttttaattta
      241 tctaatccag ataagaaagt attttcactg caagcatagg atatacgaat atatttatcc
      301 ataccaaatg ctatgccagg aacaactgca acattatatt cttctaaaaa ttgattacaa
      361 aattctatag aaaaactatc tttatattca aatttctcag atactttaga aagatctata
      421 aatatataga atgcgccatt tggattcaca tatcctacat tatcaataga gtctagtttt
      481 gatttaatta aatctcttct tgatttatat gttttaacca tattgtctat gtcaattgag
      541 caatctttca aggctccata ggctatgtat tgtgctgtta gacttgggtg agatataaga
      601 tgtccttgta tagaactcat tgctttagca atcgttttat tagatgcagt atatcctaat
      661 cttaatccag tcattgcagc tgacttagaa aaaccattta tagttattgt tatatcttta
      721 gcttcttcgc ttaatgatgc aattgatgta aattcaccag tgtagcatat tttttcatat
      781 atttcatctg ctaaaatata tattttattt tgtatgcata catctactat ttctattaat
      841 tcatcttttg tataaacact accagtagga tttgaaggat tgtttattac aagaattttt
      901 gttttatctg ttatagattt ttcaagttca tcttttgtta acttaaatcc attttctttt
      961 ttagtatcaa taaaaactgg aacagcatta actaacttaa ccatttcagg ataactaacc
     1021 caataaggct ttggtaataa gacttcatct ccttcgtctg ttaaagctag taaagtattt
     1081 gttattgagt tttttgctcc acttgataca actatttcat ctattgaata gttacagtta
     1141 ttttcttcaa taagtttttt acagatttcc tctctaagta tttttaatcc tggaactaaa
     1201 tcatatttag tgtaatcttt atttaaagaa tcaataccat aagattttgc gttattaggt
     1261 acattaaaat cgggttctcc tatactaaga tttattactt taactccatt actttccatt
     1321 tctttaactt tagaactaat acctattgtg taggatggtg ttataaagtt tagtcttttt
     1381 gataacataa aatgcctcct tttaaattat tatttatatt atacgacaaa tttaaagaat
     1441 ttacataagg aaatttgtag atatatacat taatatatat aatagcctac actttttgcc
     1501 taaaattagt gtaaaaaaaa gagaaaaaaa ttttaacttt caaagttgtt agaaacgcta
     1561 ctgttcaaaa tatccacata gtatttgcaa tgatttgcgc aagtttgact attatgtaca
     1621 aatttggtaa tcttaatata gcaattatta agataatccc tttaacttag ttgaagggga
     1681 tttttttaga cttaacatac tacatatagt ggtatgggga ttaataaaat acaatatata
     1741 gtaacaggag gtttttttaa ttggttgaat tcgtaaaaaa aagagatgga agagtaattc
     1801 catttaatga agatagaata acaagagcta tatttttagc agcaacgaat gttgcagaaa
     1861 gagaaggaat agtacctgat tataaattat ctgagcaatt aactcaagaa gtaataaagt
     1921 ttttaaatca taaatactca gaatcagttc caagtgttga agatatacaa gattctgtag
     1981 ttaaggttct tatagaaact ggccatgcaa aaactagtga agaatatata atatacagaa
     2041 ctgaaagaag tagaataaga aattcaaaaa caagattgat gaaggcaata gaggaaatta
     2101 cctttgaaga tgcagaagat gctgatataa aaagagaaaa tgcaaatatt aatggtaata
     2161 cagcaatggg aactatgtta caatatggaa gcactgtatc taaagaattt tgtaaaacac
     2221 atatattaaa accagagcat tcttttgctc atgataatgg agatatacac atacatgata
     2281 tggatttttt aaatatggga acattaactt gttgtcaaat agatgttaaa aaactattca
     2341 atggtggatt ttcaacagga catggctttt taagagagcc acaagatata ataagttatg
     2401 gtgcattagc tgcaattgct atacaaagca atcaaaacga tcaacatgga ggtcaaagta
     2461 taccattttt cgattatgga ttggctgaag gtgtatataa gacatttaag aaattctaca
     2521 taggaaattt agctaaagca ttgaagttat ttaaaggaat tgaaaataat gatgtgataa
     2581 agaacatagt atataataca gagaaagaaa caaatcaaaa agttggtctt aagagagatg
     2641 aattgtatct aaacttagaa aaagagaaat taatacagac ttttgatata gatgatgaac
     2701 ttgtaaataa gatgcaaaac tttgcatttg aagaatcgta tagagaaact gataaaaaaa
     2761 catatcaatc tatggaagca tttatacaca atctaaatac aatgcactct agagcaggtg
     2821 cacaggtacc attttcaagt gtaaacttcg gaacagatac ttctgaagaa ggaagaatgg
     2881 taactaagaa tcttctatta tctcaagaaa gaggtttagg taatggagag acaccaattt
     2941 ttccaatttt aatatttaag gtcaaagaag gcataaattt aaatcctgaa gaccctaatt
     3001 atgatttatt taaattatca tgcagagtat cagctaaaag actattccct aattttagct
     3061 ttttagatgc gccttttaat gcaaaatatt ataaaaaagg tgaaccagat acagaggcta
     3121 catatatggg ttgtagaaca agagtactta gtaatgtgtg tggttcagaa acagttagtg
     3181 gtagaggaaa catatctttt actacagtaa atttaccaag attgggtata aaacatggta
     3241 ttataaataa tgaaaaggct aatttagatg gtttctttga agaattagat gagaagataa
     3301 acttaattat agaacaatta ttggagcgcc ttgaggtaca aggaaataaa aagatgaaga
     3361 attttccatt cttaatgggg caaggtgtat ggaaaggttc tgatgattta ggaccagaag
     3421 atacactaaa agaagtaata aaacaaggaa cattgacaat tggatttata ggtttagcag
     3481 agtgccttat tgctcttata ggtaaacatc atggagaaag taaagaagct caagaattag
     3541 gattaaaaat agtgtcacat atgagacata aaatggatga agcaacggac aaatataaat
     3601 taaatttctc cttaatgggt actccagcag aaggtctttc aggtaggttt actaaaatag
     3661 ataaaaaagt ttatggagaa attaaaggta tcacagataa agaatattat actaattcat
     3721 tccatgtacc agtttattac aatataagtg catatgataa aattgagata gaagctccat
     3781 accatgaatt gactaatgca ggtcatataa catatgtaga gttagatgga gatccatctg
     3841 ataatttaga agcttttgaa actgttataa aagctatgaa agatttgggt ataggatatg
     3901 gaagtataaa tcatcctgta gatagagacc caatatgcgg tttttcaggt gtaataacaa
     3961 gtaatatatg ccctgtatgt ggaagaaatg aagatgaaag tgacatcaaa ttcgaaagaa
     4021 taagaagaat aacaggatac ttagttggta cagttgatag atttaataat gctaaaaaag
     4081 cagaagtaag agatagagta aaacatagat agttttattt gggggaataa gttatgaaaa
     4141 taagaatgtc atctactata agttatgaca gcatagttga tggaccagga ttaagaatgg
     4201 taatatggac tcaaggatgt attcataatt gtaaagagtg ccataatcct cagacacatg
     4261 atttatgtgg aggattttat atggatacag aagaaattat aaataaagtc aaatcattga
     4321 aattacaaaa aggcattacg ctatcaggag gagaaccatt tttacaacca gaaccattag
     4381 aagaaatagc aagagaagct aaaataaatg ggttagatgt atggtcatat actggattta
     4441 cgtttgaaca actgttagat aaaaaaaata gagcgtattt taaaaattta aatttactaa
     4501 agcaaattga tattttagtg gatggaaaat ttatagctga aaaaaaagat ataagcttaa
     4561 agtttagagg gtcatcaaat caaaggataa ttgatgttca aaaaagtttg aaatataaaa
     4621 aagtgttttt ggttgagcaa tatatgaagg atgatttatc tatagcagaa taaaatataa
     4681 ataaacagga ttaaatatat gcatatattt aatcctgttt attttcatat aatatttcaa
     4741 gcttgtataa tgtaacaatt aaaccaaaag actcattgta tatttgaaat taagtttttt
     4801 atagtttata ggtgttttat gtggattacg aatgatatag tattgataca ttatttaata
     4861 gattcttatg ccaagaaaca attaatttat agaaattctt aattgttaca atataaatat
     4921 ctagataagt tataagatac tgataaataa tttataaagt ttattaatct aatattgtgt
     4981 gtgaatatta agtggtcaag tagtctaaaa aatgaaaaag atttaaaaaa gtgttttaac
     5041 taaacacata ggtgttaaat tcatgtataa gtataggtta gatacataag aaataattat
     5101 gtaatatcta tctttgtaaa aaaatattaa attttgtaat ttgtggataa atatgtttat
     5161 aatgtggata atatttaatg taataagtta aagcaatatg aatcaactgt ttataatgtg
     5221 gataatatta taaatgtatg aataattgca gtatttaaaa acaaaaaaag ttaaaaaagt
     5281 tgttgactct aaaagaaaaa gttggtatag taatacttgt cctcaagaaa agggcaaaca
     5341 aataaagcat aa
//
LOCUS       DAEQCW010000170         5345 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.171, whole genome shotgun sequence.
ACCESSION   DAEQCW010000170 DAEQCW010000000
VERSION     DAEQCW010000170.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5345)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5345)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5345
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.171"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(234..2513)
                     /locus_tag="KRO40_003415"
     CDS             complement(234..2513)
                     /locus_tag="KRO40_003415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2094209.1"
                     /translation="MLSDAKNNRYGLSIIAVISILVITISCLIYGSRLNKTLGEETNQ
                     YLSEIANQSVNVLKKQINGDIKLLESISIFIEGEESFEVDNILSILKRQAINSSFKRM
                     GVILPNGTAYTTDGYIEDFSKRDYFLKSMQGEVVITGKLKDVIEDDKNTNSNINVYSV
                     PIYKDNEVKGVIFATHSTKLYEKILSVPTFNGKGYSYITRSNGDIVLNPSSKNANSTK
                     ENLFSYIGRSDSISKSSINNMKSNIKNFKSGSLSYSMFGKGYYLSYAPIGINDWYLFS
                     EVPKTAISEKSYAIIKLTLSACVVLIIIFTALTIYILFIHKKSKEKLEEFAFKDNVTG
                     IGNSNKFNLEGGKFLSSHEKKNLVLIYFDIDKFKLVNDRFGYEEGDRVLKEIAEIIKN
                     IFKEQSVFSRISNDNFAIIFEKKNNRESIIEICELIRKKLSMIKTSLGVELNLIPSIG
                     VYFVEEGETNISTCLDKAMIAKTTVKRKYLKVYEIYAENLKETLIEERDIEQEMHDAL
                     KNEQFKVYLQPKVDLSTTKIVGAEALVRWQHPKKGLISPGVFIPIFEKNGFITELDMF
                     VFTQVCKNFKRWENENFPTFPISINLSRVHLENPGFISELERITKEYEIEPNLIEIEL
                     TESAIFDNTKILFKIMQTLKSVGFKISMDDFGSGYSSLNMLKDMPIDVLKLDRQFFIT
                     VGNAKKSQIVVSSIVQMAKQLDIKVVSEGVETVEQAEFLRFIGCDMAQGFLFARPMPI
                     EEYEKLILDRYSLNRKETN"
     gene            complement(2784..4238)
                     /locus_tag="KRO40_003416"
     CDS             complement(2784..4238)
                     /locus_tag="KRO40_003416"
                     /EC_number="6.3.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HBH2094210.1"
                     /translation="MKLNDIIQGLDIINVKGELNIDINNVQYDSRKVTKGTLFICIKG
                     FVSDGHKYIKDAIEKGASAFLVEEDVAIKGCTFIKVKDTRKDMAKVADNFYNHPSQKF
                     NVIGVTGTNGKTSITTILNEILTLNKNKVGLIGTIKIFDGEKDIVSNSTTPESIDLQY
                     HFNNMLDNGCDYCAMEVSSHSLALNRVDETDFKLGIFTNLTPDHLDFHKDLEDYRKAK
                     EKLFFKTTMANIINIDDEGGKKIYENIKGINVPCYTYGVDTKADFMARDIKSDSDGVS
                     YRLITPSYEEVIFIPVPGMFTVYNTLAVIAACYVLGIPKPIYKEGLRLSNGVSGRFET
                     VPNDKGISVIVDYAHTPDALENVLKTTQQFAEGKIISVFGCGGDRDTEKRPLMGAIGQ
                     KYSDLCIITSDNPRTEEPEAIIKDILEGIDKKKENYHVVVDREQAIAEAISMAKKDDV
                     VIITGKGHETYQIIGKVKHHFDDKEVANECLSKM"
     gene            4402..5271
                     /locus_tag="KRO40_003417"
     CDS             4402..5271
                     /locus_tag="KRO40_003417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2094211.1"
                     /translation="MDNKIGYLNDNFKIFNIRDKKDIQFEYHNHDFNKIIIFINGNVT
                     YFVDGIPYKLKPWDILFISNNEIHKPVIDSNVFYERIAIWISPEFMKKNSDATSDLEK
                     CFKIATENKCNRLRLNIHDIESIKSFIEQINISESNTEFGNEILRNALFIQLMIFLNR
                     IFLKNENMESTEDVFYDETIKKVLNYINSNIDDKLSIDSISSEFFISKYYLMRKFKSH
                     TGTSIHNYIVQKRLILAKSLITNGHLMSEVCNKCGFNDYSSFVRAFKKNYGVSPKNYI
                     NNKNPLDITLLDE"
BASE COUNT         1824 a          837 c          566 g         2118 t
ORIGIN      
        1 attactatta ttactatcta aagtattttg ctataatccc atatactctt acctcaaaaa
       61 catccaaatg taaaaaatac tacatattaa taaactttgc ccaataattc ctaaaataat
      121 atcctaacaa tgatttatgt ttttataata gtatattttt acataaaaaa gtgaacattg
      181 attaacaaag ttcacttttt tataaatttt tatgttataa ttcacaattt tatttaattt
      241 gtttcttttc tatttaaact atatctatct aatattaatt tttcatattc ttctattggc
      301 attggtctag caaataaaaa tccttgggcc atatcacaac ctataaacct taaaaactct
      361 gcttgctcta cagtttcaac accttctgaa acaactttta tatcaagttg ctttgccatt
      421 tgaacaatac ttgaaactac aatttgactc ttttttgcat ttcccactgt tataaagaat
      481 tgcctatcta atttcaatac atcaattggc atatctttaa gcatatttaa agaagaataa
      541 ccagaaccaa aatcatccat agaaatttta aatccaacag atttcaaagt ttgcattatt
      601 ttaaataata tttttgtatt gtcaaatatt gcactttctg tcaattcaat ctcaattaaa
      661 tttggttcaa tttcatattc ttttgttatt ctttcaagct cagaaataaa gcctggattc
      721 tcaagatgta ctcttgataa gtttattgat ataggaaatg tggggaaatt ttcattttcc
      781 caacgtttaa aatttttaca aacttgggta aatacaaaca tatccaattc tgttataaaa
      841 ccatttttct caaaaatagg aataaataca cctggactta ttagaccttt tttaggatgt
      901 tgccaacgta caagtgcttc agcacctaca attttagtag ttgataaatc aaccttaggc
      961 tgtaaataaa ctttaaattg ttcatttttt aaagcatcat gcatttcttg ttcaatatca
     1021 cgttcttcta tgagagtttc ttttaaattt tcagcataaa tctcataaac ttttaaatat
     1081 tttcttttta ctgtagtttt tgcaatcata gctttgtcaa gacaggtaga aatatttgtt
     1141 tctccctctt caacaaaata tacacctatg gatggaatta aattgagttc tactcccaaa
     1201 cttgttttta tcattgacaa ttttttacgt ataagttcac atatttctat aattgactct
     1261 ctattatttt tcttttcaaa tattatagca aaattgtcat ttgaaattct tgaaaataca
     1321 gattgctctt taaatatatt cttaattatc tctgctattt cctttaatac tctatctcct
     1381 tcttcatacc caaacctatc atttactagc ttaaacttat ctatatcaaa ataaattaaa
     1441 actagattct ttttctcatg agaggataaa aattttcccc cttcaagatt aaatttattt
     1501 gaattgccaa tacctgtaac gttatcttta aaagcaaatt cttccaattt ttccttactc
     1561 tttttatgta taaatagtat ataaattgtt aatgccgtaa agattataat caagactaca
     1621 catgctgata atgtaagttt tataatagca tatgatttct cagatatagc agttttagga
     1681 acttcagaaa aaagatacca atcattgatt cctattgggg cataacttaa ataatatcct
     1741 tttccaaaca tactataact taatgaacct gatttaaagt tttttatatt tgacttcata
     1801 ttgttgatac tagattttga tattgaatca cttctgccaa tgtaagaaaa taaattttct
     1861 ttagtagagt tggcgttttt actgcttgga tttaaaacaa tatcaccatt acttctagtt
     1921 atataagaat atccttttcc attaaatgta ggtacagaaa gtattttttc atacaacttc
     1981 gtactatgtg tggcaaatat aactccttta acctcattat ctttataaat tggtacagaa
     2041 tatacattaa tattactatt ggtattttta tcatcttcta ttacatcttt taatttgcct
     2101 gttataacca cttctccttg cattgatttt aagaaataat ctcttttaga aaagtcttct
     2161 atataaccat ctgtagtgta tgctgtacca tttggtaaaa taactcccat tcttttaaat
     2221 gaactattaa tagcttgcct ttttagtata gaaaggatat tatctacttc aaaagactct
     2281 tctccttcaa taaatattga aattgactct agtaacttta tatctccatt aatttgtttt
     2341 tttaacacat tgacgctttg atttgctatt tctgaaagat attgattcgt ttcttcacct
     2401 aatgtcttat tcaaccttga accataaatc aaacaggaaa ttgtaattac taagatactt
     2461 atgacagcaa ttatggacaa accataccta ttattttttg catcacttaa cattatgctt
     2521 cctgcctttc tcgaatctat gtatgtataa tcattatctt atgacaatta ttgtaaacat
     2581 tttataataa tacttatttt tccatattta ctgtaattat acaaaattat aaactttatt
     2641 acaacaataa attaattaat atagatatta gtgtttatat tattgcatta tctattttac
     2701 aattatttac atataaaaaa atgtaatatc aaagtgaagc ttgatattac atttttgttc
     2761 ttgtattttg tttaattttt atgctacatc ttacttaaac actcatttgc aacttcttta
     2821 tcatcaaaat gatgcttaac tttacctata atttgataag tttcatgtcc cttacctgtt
     2881 ataattacaa catcatcctt ttttgccata cttatagctt ctgctatagc ttgttctcta
     2941 tcaacaacaa catggtaatt ttcttttttc ttgtcaattc cttcaagtat atcttttatt
     3001 attgcctctg gttcttcagt tcttggatta tcagaagtta taatacataa atcagaatat
     3061 ttttgtccaa ttgctcccat caaaggtctc ttttcagtat ctctatctcc accacaccca
     3121 aacacagaaa ttatttttcc ttctgcaaat tgttgagttg tctttagtac attttcaagt
     3181 gcgtcaggag tatgagcata gtctacaatt acgcttatac ctttatcatt tggaactgtt
     3241 tcaaaccttc ctgatactcc attagaaagt ctaaggcctt ctttatatat tggtttaggt
     3301 atgccaagta catagcaagc agctataact gctaaagtat tatatactgt aaacattcct
     3361 ggaactggta taaatattac ttcttcatat gaaggtgtta ttaatctata agatactcca
     3421 tccgaatctg attttatatc tctagccata aaatcagcct tagtatcaac accataagtg
     3481 taacaaggta catttatacc ttttatattt tcatatatct tctttccacc ttcatcatct
     3541 atgtttatta tatttgccat agtagtctta aaaaataatt tttcttttgc ttttctataa
     3601 tcctctaaat ctttatgaaa atctaaatgg tctggtgtta aatttgtaaa tatgcctagt
     3661 ttaaagtctg tttcatcaac tctatttaat gccaatgaat gtgatgaaac ttccattgca
     3721 cagtagtcac atccattatc caacatatta ttaaaatgat attgtaaatc tatactttct
     3781 ggagttgttg aattggaaac aatgtctttt tctccatcaa aaatttttat agttcctata
     3841 agtccaactt tattcttatt taaagttaat atctcattta gtatagtagt tatactagtt
     3901 tttccattag tacctgtaac tcctataacg ttaaattttt gagatggatg attgtaaaaa
     3961 ttatcagcta cttttgccat atcttttctt gtatctttta cctttataaa tgtacatcct
     4021 tttattgcta catcttcttc aacaagaaat gcacttgctc ccttttctat ggcatctttt
     4081 atatacttat gaccatctga cacaaatcct tttatacata taaataatgt accttttgta
     4141 acctttcttg aatcatattg tacattatta atatctatat ttaattcacc cttgacattg
     4201 attatatcca acccctgtat aatatcattt aatttcataa atgctttcct ccctttaaac
     4261 tctttctgct aaaattacac tacatataat attatattaa gaatttttta ctatgtgaat
     4321 ggttaaaaat gcttgaaaca ttgcaaaaaa tgctctataa ttttctataa tataactgag
     4381 gaaaggtctt ctataaaaac tatggataat aaaatcgggt acttaaacga taactttaaa
     4441 atatttaata ttagagataa aaaagatata caatttgaat accataatca tgattttaat
     4501 aagataatta tatttataaa tggaaatgta acttattttg ttgatggtat tccctataaa
     4561 ctaaagcctt gggatatact ctttatcagc aataatgaaa tacataaacc agttatagat
     4621 tcaaatgtct tttatgagag aattgcaata tggattagcc cagaatttat gaaaaaaaat
     4681 agtgatgcta ctagtgactt agaaaaatgt tttaaaatag ctacagagaa taaatgcaat
     4741 agattgcgtt taaatataca tgatattgaa tctattaaga gttttattga gcaaataaat
     4801 atttccgaat ccaatactga atttggaaat gaaatattga gaaatgcatt atttatacaa
     4861 cttatgatat tcttaaacag aattttccta aaaaatgaaa atatggaatc aacagaagac
     4921 gttttttatg atgaaactat taagaaagta ttaaactata taaattcaaa tatagatgat
     4981 aagctttcaa tagatagcat atcgtctgaa ttttttataa gtaagtatta tcttatgaga
     5041 aaatttaaat ctcatactgg aacgtctata cacaattata tagttcaaaa aagattaatt
     5101 ttggcaaagt cactaataac caatggtcac cttatgagtg aagtttgtaa taaatgtgga
     5161 ttcaacgatt attctagttt tgtaagggca tttaaaaaaa actacggtgt atctcctaaa
     5221 aattatataa acaataaaaa tcctttagat attactcttt tagatgaata gataatttat
     5281 gtaaatttta ttttaataaa acttgaagta ttagtgtatt tatcttacta atacctcaag
     5341 ttttt
//
LOCUS       DAEQCW010000171         5336 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.172, whole genome shotgun sequence.
ACCESSION   DAEQCW010000171 DAEQCW010000000
VERSION     DAEQCW010000171.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5336)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.172"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            74..454
                     /locus_tag="KRO40_003418"
     CDS             74..454
                     /locus_tag="KRO40_003418"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HBH2094212.1"
                     /translation="MNIFDIGVDIIEIDRIRKAVDKNNRFLEKIFTDREIEYFNSKNF
                     KAESIAGNFAAKEAISKSIGTGIRLFNFKDIEVLRNEMGKPIVKTYNNLAKMCIDYNV
                     LEIKVSISHSKDYAIANAITIIKD"
     gene            469..930
                     /locus_tag="KRO40_003419"
     CDS             469..930
                     /locus_tag="KRO40_003419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBH2094213.1"
                     /translation="MMDKTAKEIMTTDVIVAKQDDSIADVANMLIAEKIGGLPVVDSE
                     NRVVGIISETDILKKEKYIEAPLYINLLQGLIFLDDLKKVEKDIKQVAAYKVGELMSK
                     DIIKVHEDDKFDDVANVMIKKSINRVPVVDDDNKLKGIICRYDIIKALYNE"
     gene            951..1541
                     /locus_tag="KRO40_003420"
     CDS             951..1541
                     /locus_tag="KRO40_003420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094214.1"
                     /translation="MRKKWTIVCIMFLALVIIVIGCQKRQSTKEEVYKDFQKQISDMN
                     YYSCKAEVEVVGNKSPHNYVLIHTYKKTDNYKLEVISPKHLKGKSIEYQGDKILVKNP
                     KISDVVELPNTGKNNQYLFVGDFIKNYLQNEEMKVKLSKGHLVLETFIPGDNKYFNKQ
                     VLYVNADTKNPEKMEVLDKEGVPRFTVKYKDFEYRN"
     gene            1556..2713
                     /gene="alr"
                     /locus_tag="KRO40_003421"
     CDS             1556..2713
                     /gene="alr"
                     /locus_tag="KRO40_003421"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBH2094215.1"
                     /translation="MQKITVPTWAEINLDNLRFNLNNIKNLLEEDIKICGVIKADAYG
                     HGAVEVAKLLEKEKVDYLAVARTAEGIELRQNGITLPILNLGYTPDEAFEDSIKNKIT
                     MTVYSLETAQKINEIAKSLGEKACVHVKIDSGMTRIGFQPNEESVQEIIELNKLEYID
                     LEGMFTHFATADEVSKEYTYKQANNYKFMSDKLDEAGVKIAIKHVSNSAAIMDCPDLR
                     LNMVRAGIILYGHYPSDDVFKDRLELRPAMKLKSKIGHIKQVEPGVGISYGLKYTTTG
                     KETIATVPIGYADGFTRIQKNPKVLIKGEVFDVVGRICMDQIMVRIDKDIDIKVGDEV
                     ILFGEGEVTAERIAKDLGTINYEVLCMISRRVDRVYMENNELVQINSYLLK"
     gene            2746..3033
                     /locus_tag="KRO40_003422"
     CDS             2746..3033
                     /locus_tag="KRO40_003422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="HBH2094216.1"
                     /translation="MYDKSKEKIEVTLPDSLISEVDSIVQMENSNREDFAKAAFQFYI
                     TQKKKIHIKESMKTGYREMGQINLSLAELGMTVEEVSSDDKNEGKIAQGEY"
     gene            3002..3385
                     /locus_tag="KRO40_003423"
     CDS             3002..3385
                     /locus_tag="KRO40_003423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="HBH2094217.1"
                     /translation="MKGRLPKVSTNCEIKRGDLYYADLSPVVGSEQGGVRPVLIIQND
                     VGNKYSPTVIVSAITSQINKAKLPTHVEISSNEYGLNKDSVILLEQIRTIDKKRLREK
                     IGCLDENMMIKVDDGLQISLGLFTF"
     gene            3556..4383
                     /locus_tag="KRO40_003424"
     CDS             3556..4383
                     /locus_tag="KRO40_003424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBH2094218.1"
                     /translation="MRDHKGLNEIARIIRRDIVSMIHRAKSGHPGGSLSVVEILTALY
                     FDEMNVDSSNPKMEDRDRFVLSKGHAAPALYATLAEKGYFDKEELNGLRKIGRMLQGH
                     PDMKGTPGVEISTGSLGQGFSVACGMAMASKLDNAPWNVYTLLGDGEVQEGIVWEAAM
                     SAAHYKLDNLIAFLDNNGLQIDGDIESVMSLGSIVDKFKAFGWNVIEIDGHDFDQIFA
                     ALDIAKSTVKKPTMIVAKTIKGKGISFMENQAGWHGTAPSDEELEKALLELGGADNE"
     gene            4376..5317
                     /locus_tag="KRO40_003425"
     CDS             4376..5317
                     /locus_tag="KRO40_003425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBH2094219.1"
                     /translation="MSKMATREAYGKALVKLGQINDNVVVLDADLSKSTKTHDFYKSF
                     PDRFFNMGIAEQNLIGAACGLSTAGKIPFASTFAMFATGRAFEIIRNSVCYPKLNVKI
                     CATHAGLTVGEDGASHESVEDIAIMRAIPNMTVLVPADGVETEKIIFEIAKYNGPVYV
                     RLGRSSVPVLFDEDYKFEIGKGTVLREGKDVSIIACGIMVNEALLAQEKLQEEGISAR
                     VINMSSIKPIDKDLILESAKETNAIVTVEEHSIIGGLGSAVSEVVGESCPTIVKKVGI
                     KDTFGESGTPNELLKKYELTCDDIIKTVKEVIIAKRM"
BASE COUNT         2122 a          566 c         1073 g         1575 t
ORIGIN      
        1 gtattatcga tagtaaattt ataaattcat tattaattat tgaaagaagt attataaatt
       61 ttctggagga acaatgaata tatttgatat tggcgtagat ataattgaaa ttgatagaat
      121 aagaaaggct gtagacaaaa ataataggtt tttggagaag atatttacag atagagaaat
      181 agagtatttt aattctaaga attttaaagc agaaagtata gcaggtaatt tcgcagccaa
      241 ggaagctata agtaaatcta taggtacagg aattagattg tttaatttta aagatataga
      301 agttctcaga aatgaaatgg gaaaaccaat agtaaaaact tataataatc tagcaaaaat
      361 gtgcatagat tataatgttt tagaaataaa agtttcaata tcacattcaa aagattatgc
      421 tatagcaaat gcgataacca taattaagga ctaaggagtg attacattat gatggataaa
      481 acagcaaaag aaataatgac aacagatgta atagtagcaa aacaagatga tagtatagca
      541 gatgtagcta atatgctaat tgcagaaaaa ataggaggtc tgccagttgt agattcagag
      601 aatagagttg ttggaataat ttctgaaaca gatattctta aaaaagaaaa atatatagaa
      661 gcacctctct atataaatct attacaagga ttgattttct tagatgactt aaaaaaagtt
      721 gaaaaagata taaaacaagt agctgcttat aaggttggag aacttatgtc taaagatata
      781 ataaaggttc atgaagatga taagtttgat gatgtagcta atgtaatgat taaaaaatca
      841 ataaacagag ttcctgtagt agatgatgac aacaaactta aaggtataat ttgtagatat
      901 gatataataa aagctttata caatgaataa actgaagtag gaggtgtgat gtgagaaaaa
      961 agtggaccat agtatgtatt atgttcttgg cactggttat aattgtaata ggatgccaaa
     1021 aacgacagtc cacaaaagaa gaagtataca aagattttca aaagcagatt tctgatatga
     1081 attattacag ttgtaaagct gaagtagaag tagttggaaa taaaagtcca cacaattatg
     1141 ttttaattca tacttataaa aaaaccgata actataaatt agaagtaatt tccccaaaac
     1201 atttaaaagg gaaaagtata gaatatcaag gtgataaaat attagttaaa aatccaaaga
     1261 ttagtgatgt agtggagtta cctaatacag gaaaaaataa tcaatatctt tttgtaggag
     1321 actttataaa aaactatctt caaaatgagg agatgaaagt aaagttatcc aaaggacatt
     1381 tggttttaga gacttttatt cctggggata ataaatattt taacaagcaa gtattatatg
     1441 taaatgctga cacaaaaaat cctgaaaaaa tggaagtgtt agataaagag ggagtgccaa
     1501 gatttacagt aaaatacaaa gattttgaat acagaaacta agggggacta aagacatgca
     1561 aaaaataaca gtgcctacat gggcagagat aaatctagat aacttaagat ttaacttaaa
     1621 taatattaaa aatttattag aagaagatat taagatttgt ggagtaataa aagctgatgc
     1681 atatggacat ggtgcagtag aagttgcaaa attgctagaa aaagaaaaag tagattactt
     1741 agcagtagca agaactgctg aaggaattga acttagacaa aatggcataa cacttcctat
     1801 tttgaacttg ggatatactc cagacgaagc ttttgaagat tctataaaaa ataaaataac
     1861 tatgacagtt tattctttag aaacagcaca aaagataaat gaaattgcaa aatctttagg
     1921 agaaaaagcc tgtgttcatg ttaaaataga ctcagggatg actagaatag gtttccaacc
     1981 taatgaggag tcagtacagg aaataataga attaaataaa ttagaatata tagatttaga
     2041 aggtatgttt actcattttg ctacagctga tgaagtaagt aaagagtaca cttataaaca
     2101 agctaataat tataaattta tgtctgataa attagatgag gctggtgtaa aaatagctat
     2161 aaaacatgta tcaaacagtg cagctattat ggattgccct gatttaagat taaatatggt
     2221 aagagcagga ataatattat atggtcatta tccatctgat gatgtattta aagatagatt
     2281 agaattaaga ccagccatga aattaaaatc aaaaatcgga catataaaac aagttgaacc
     2341 aggtgtagga ataagttatg gactaaaata cacaactaca ggtaaagaaa caatagctac
     2401 agttccaata ggatacgcag atggatttac tagaatccaa aaaaatccaa aggttcttat
     2461 taagggagaa gtgtttgatg tagttggtag aatatgtatg gatcaaataa tggttagaat
     2521 tgacaaagat atagacataa aagttggaga tgaggttata ctatttggag aaggcgaagt
     2581 tacagctgag cgtatagcta aagacttagg aactataaac tatgaagtgt tatgtatgat
     2641 atcaagaaga gttgaccgtg tttatatgga aaataatgag cttgtacaaa taaacagtta
     2701 tttgctaaaa taaaaccatg atattataat ctgggaggcg attttgtgta cgataagagt
     2761 aaagaaaaaa tagaagttac tttacctgac tctctgattt ctgaagttga tagtatagtt
     2821 cagatggaga acagtaacag agaagatttt gcaaaagctg cttttcagtt ctatataact
     2881 cagaaaaaga aaattcatat taaagaatct atgaaaacgg gttatagaga aatgggtcaa
     2941 attaatctgt cactagctga attaggtatg acagttgaag aagtatcttc tgatgataaa
     3001 aatgaaggga agattgccca aggtgagtac taattgtgaa ataaagcgtg gtgatttata
     3061 ttacgctgat ttaagtccag ttgttggttc agagcaggga ggcgttagac ctgttctgat
     3121 aatacaaaat gatgtaggta ataaatatag tcctacagtt atagtatcag ctataacatc
     3181 tcagattaat aaagccaaat tacctactca tgtagagata agttccaatg aatatgggct
     3241 taataaagac tcagtaattc ttttagagca aattagaact atcgataaaa agagactgag
     3301 ggaaaaaatt ggttgtctag atgaaaatat gatgataaaa gtagatgatg gacttcaaat
     3361 aagtttagga ttgtttactt tttaaagagg gatttgtctt ttattagaca atcccttttt
     3421 tcttttaaat atctcttaag gtttaatttt aatgtactat gttaataaaa ttaaaaataa
     3481 cgcaaaaaaa tagcataaaa gtgatataat aatatggaat tgatataaaa ttacgaactc
     3541 aagggaggta attgcatgag agaccataaa ggattaaatg agattgcgcg tatcataaga
     3601 agagatatag tttcaatgat acatagagcc aaatctggac atccaggagg gtcattatca
     3661 gtagttgaaa tacttactgc gttatacttt gatgaaatga atgtggattc ttcaaatcct
     3721 aaaatggagg atagagatag atttgtatta tcaaaaggac atgctgcacc agcattatat
     3781 gctacattgg ctgaaaaagg ttattttgat aaggaagaac tgaatggatt aaggaagata
     3841 ggaaggatgt tacaaggtca tccagacatg aaaggcacgc caggtgtgga aatatctact
     3901 ggttctttag gtcaaggttt ttcagttgca tgtggtatgg ctatggcatc aaagttggat
     3961 aatgctccgt ggaatgtgta tactttgctt ggtgatggtg aggttcaaga aggaattgtt
     4021 tgggaagctg ctatgagtgc tgcacattat aaacttgata atttaattgc ttttttagat
     4081 aataatggac ttcaaataga tggagatata gaaagcgtaa tgagtttagg ttcaatagtt
     4141 gataaattta aagcttttgg ttggaatgta attgagatag atggacatga ttttgaccaa
     4201 atatttgcgg ctcttgatat agctaaatca acagttaaaa aacctacaat gatagttgca
     4261 aaaactataa aaggcaaagg aatatctttt atggaaaatc aagcaggatg gcatgggaca
     4321 gctccaagtg atgaggagct agaaaaagcc ttgcttgaat taggaggtgc tgacaatgag
     4381 taaaatggcg acgagagaag catatggtaa agcattagta aaattaggtc aaataaatga
     4441 caatgttgta gtattagatg cagatttatc aaagtctaca aaaacacatg atttttacaa
     4501 gtcatttcca gatagatttt ttaatatggg tatagctgaa caaaatttaa taggcgctgc
     4561 ttgtggatta tcaactgctg gtaaaatacc ttttgcaagt acttttgcta tgtttgctac
     4621 gggaagggct tttgagatta taagaaattc agtttgttat ccaaagctaa atgtaaaaat
     4681 atgtgctact catgcaggtc ttactgttgg agaggatgga gcatctcatg aaagtgtgga
     4741 agatattgct ataatgagag ctataccaaa tatgacagtt cttgttccag ctgatggagt
     4801 tgaaacagaa aaaattattt ttgaaatagc taagtacaat ggacctgttt atgttagatt
     4861 agggagaagt tcagtaccag ttttatttga tgaagattat aaatttgaaa taggaaaagg
     4921 tacagtctta agagaaggaa aggatgtatc aattatagct tgtggaatta tggtaaatga
     4981 agctctatta gcacaagaaa agttgcaaga agaaggtata agtgctagag ttataaacat
     5041 gtcctcgata aaacctatag acaaagattt aatattagaa tcagcaaaag aaacgaatgc
     5101 tattgtaact gtagaagaac atagcataat tgggggatta ggttctgctg taagtgaggt
     5161 agtaggagag tcttgtccaa ccattgtaaa gaaagttgga attaaagata catttggaga
     5221 atctggtact ccaaatgaat tgttaaaaaa atatgaatta acttgtgatg acataataaa
     5281 gactgttaaa gaagttatta ttgcaaaaag aatgtaagag atataaatta ttcatg
//
LOCUS       DAEQCW010000172         5084 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.173, whole genome shotgun sequence.
ACCESSION   DAEQCW010000172 DAEQCW010000000
VERSION     DAEQCW010000172.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5084)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5084)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5084
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.173"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            35..1918
                     /locus_tag="KRO40_003426"
     CDS             35..1918
                     /locus_tag="KRO40_003426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
                     /protein_id="HBH2094220.1"
                     /translation="MSNKNKENITLSNQIKGTIQNSLTKEAILHIPMSNYAYGYDRET
                     LHIRLRTKKNEAKRVILRIGDQYVWDKGGAGGGNLNASGVGWSGGTNIVMSKEVETEL
                     FDYWIAKCKPLNKRSRYGFIIEGQEEKLLFTEKRIIELGNENDEKELCEIGNFFGYPY
                     LNYIDIPKVPNWVKDTVWYQIFPDRFANGDPSINPEGVDKWGAIPTRDNFTGGDLQGV
                     IEHLDYLSDLGINGIYFCPITIGKTNHRYDTVDYMEVDPTLGDKETLKKLIEEAHKRN
                     IRIMLDAVFNHIGYYSKQWQDVVQNKENSRYKNWFYIKDMSKIDTPIEQIDEKNIPYE
                     TFGCEKYMPKLNTENSEVIKYLLDVGKYWIQEFDIDAWRLDVSNEVDHVFWRKFREEV
                     KKVKPDIYILGEIWHGSLPWLMGDQFDSVMNYLMSEAMKKFFCTDEINAEEFKYMIND
                     VMVSYPIQVSEVIFNLLGSHDTTRILTYANGNIDRFKLAYMFMFVQTGCPCIYYGDEI
                     GMEGELSSISEGQRKCMKWNEEKWNKDIFDFMKKIIRLRKENKELRSISNEWVLADKE
                     NGTIILKKESISIIINNSSKNIILTLPDYLANKKVKDLYEEEIVDLKEELMLEKYKFI
                     ILK"
     gene            2143..2823
                     /gene="pgmB"
                     /locus_tag="KRO40_003427"
     CDS             2143..2823
                     /gene="pgmB"
                     /locus_tag="KRO40_003427"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBH2094221.1"
                     /translation="MIEAFIFDLDGVITDTAYYHYMAWRKLAHKVGIDIDTKFNESLK
                     GISRMESLDRILEFGNKKYSFSEEEKVRMAEEKNNYYVSLIDEITSNDILPGIESLLI
                     DVKSNNIKIGLSSASKNAINVLNHLGISDKFDFIADAGKCKNNKPHPEIFLMSAKGLN
                     VNPQNCIGIEDASAGIDAINSANMFSVGVGNYENLKKANLVVDSTNQLKFEYIQEKYN
                     EYIVRRII"
     gene            2820..>5084
                     /locus_tag="KRO40_003428"
     CDS             2820..>5084
                     /locus_tag="KRO40_003428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_097546124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBH2094222.1"
                     /translation="MKCLFSNVDEWKIIQDKIEIKENRLAESIMSIGNGYMGMRGNYE
                     ENYSGDTHKGSYIAGVWFPDKTRVGWWKNGYPEYFGKIPNSVNYIGVRIFIDDVELDL
                     AKCKVEDFYRELDMKNGILNRRFIVNINDKKFEVRVARFLSISVKELAVIKYSIKSLN
                     SNTKIKFVPYLDSNIKNEDSNYEEKFWNGISSSSLEYKGSILSRTKENAFNTPVFTVG
                     SMMYIKTNGDVEAISHESDYNYCENSITMDVLKNEVASIEKYVSITSTRDYKESELLR
                     KCEDILNRELSKSYDDILNEHTKLWNKRWESADVKINGDKSSQQGIRYNLFQLFSTYY
                     GEDSRLNIGPKGFTGEKYGGATYWDTEAFCVPVYLGVADKEVTRNLLEYRYNQLEQAK
                     DNAKKLGLKGALYPMVTFDGVECHNEWEITFEEIHRNGSIVYAIYNYTNYTGDYKYIK
                     EKGIDVIIEIARFWASRVHLSTKKDLYMIHGVTGPNEYENNINNNWYTNYIAKWCLDY
                     AVENILRLEKECNECIDRNNVTREEVEFWKIISNKMYLPYDEELQIIIQNDNFLDKEF
                     VEVKDLPKENFPLNQNWSWDKILRSCFIKQADVLQGIYYFGNRFTKEEKKRNFDFYEK
                     YTVHESSLSSSIYSIIASEIDNLEKAYELYSRTARLDLDNYNNDTNDGLHITSMSGSW
                     LSIVHGFAGMRTWNETLSFDPKLPKEWKNYSFNINYRDNIINVDVCSDLIKIENLKGR
                     PIKIIVYGKKYILEK"
BASE COUNT         2106 a          454 c          962 g         1562 t
ORIGIN      
        1 tatataaatt attataaagg agggaaattt taaaatgtct aataaaaata aagaaaatat
       61 aactttaagt aatcaaatca aaggaacaat tcaaaatagt ttaacaaaag aagctatatt
      121 acatatacca atgagcaatt atgcctatgg ttatgataga gaaacactac atataagact
      181 tagaactaaa aaaaatgaag cgaaaagagt aattttacga ataggagacc aatatgtgtg
      241 ggataaagga ggtgcaggag gaggaaattt aaatgcatct ggagttggtt ggtctggtgg
      301 aacaaatata gtaatgagta aagaagtaga aactgaatta tttgactatt ggatagctaa
      361 gtgtaagcct ttaaataaac gctcacgata tggttttata atagaaggtc aagaggaaaa
      421 acttttattt acagaaaaaa gaataataga gttgggaaat gaaaatgatg aaaaggaatt
      481 atgtgaaata ggtaattttt ttggatatcc atatttaaat tatatagata tacctaaagt
      541 gccaaattgg gtgaaagata ctgtttggta tcagatattt ccagatagat ttgcaaatgg
      601 tgacccgtct ataaacccag aaggagtaga taaatgggga gctattccaa ccagagataa
      661 ttttacaggt ggagatttac aaggtgtgat agaacactta gattatttga gtgatttggg
      721 aataaacgga atttactttt gccctattac aattggaaaa accaatcata gatatgatac
      781 ggtagattat atggaggtag accctacatt aggagataaa gagactttaa aaaaactaat
      841 agaagaagcg cataagagaa atataagaat aatgttggat gctgttttta atcatatagg
      901 atattattct aaacagtggc aagatgtagt tcaaaataag gaaaattctc gatataaaaa
      961 ctggttttat ataaaagata tgagtaaaat tgatactcca atagaacaaa tagatgaaaa
     1021 aaatatacct tatgaaacct ttgggtgtga aaaatatatg cctaaactta atacagaaaa
     1081 ttcagaagta ataaaatatt tattggatgt aggcaagtac tggatacagg aatttgatat
     1141 agatgcgtgg agattagatg tttcaaatga agtagaccat gttttttgga gaaagtttag
     1201 agaagaagtc aaaaaagtaa aaccagacat ttatatattg ggagaaattt ggcatggtag
     1261 tttaccatgg ctaatgggtg accaatttga ttcagttatg aattacttga tgtcagaagc
     1321 catgaaaaaa ttcttttgta cagatgagat aaacgccgaa gaatttaagt atatgataaa
     1381 tgatgtaatg gtaagttatc caatacaagt tagtgaagtt atttttaatt tacttggaag
     1441 tcacgatact acaagaatat tgacttatgc taatggaaat attgatagat ttaaacttgc
     1501 atatatgttt atgtttgtac aaacaggatg tccttgtata tactatggtg atgaaatcgg
     1561 aatggaagga gaattaagtt caatatctga aggtcaaaga aaatgtatga aatggaatga
     1621 agaaaaatgg aataaggata tatttgattt tatgaagaag attattagac ttcgtaaaga
     1681 aaataaagaa cttaggtcta tatcaaatga atgggtgtta gcagataagg aaaatggaac
     1741 gattatattg aaaaaagaat ctatttctat aataataaat aattcatcta aaaatataat
     1801 tttgacgtta ccagattatt tagcaaataa aaaagtaaaa gatttatatg aagaagaaat
     1861 agttgattta aaagaagaac taatgttaga gaaatacaag ttcattattt taaaataata
     1921 caaaaaagta tttattttag atttcatgtt aaattattat acagtttaaa taagtcttta
     1981 taaacgataa aaaaatatgg tctacaagtg agtgaattga aagtagattt taaattaaag
     2041 actgagttag agtagataat tttataaata atatcttaaa tacaagatag aaaataaatt
     2101 gattattagt ctaaaaattt cttgtagaaa gaggaaataa gaatgattga agcatttata
     2161 tttgatttag atggtgtaat tacagatact gcatattatc actatatggc ttggagaaaa
     2221 ctagcccata aagttgggat agatatagac acaaaattta atgaatcttt aaaaggcata
     2281 agtagaatgg agtcattgga caggatatta gaatttggaa ataagaaata ttcattttca
     2341 gaagaagaaa aagtgagaat ggctgaagaa aaaaataatt actatgtatc attgatagat
     2401 gagataactt caaatgatat tttgccaggt atagaaagct tgttaattga tgtaaaatct
     2461 aataatataa agataggtct atcttctgca agtaagaatg caataaatgt attaaatcat
     2521 ttgggtataa gtgataaatt tgattttata gctgatgcag gaaaatgtaa aaacaataaa
     2581 ccacatccag agatatttct tatgtcagcg aaagggctta atgtaaatcc acaaaattgc
     2641 atagggatag aggatgcaag tgcaggtata gacgctataa actcagctaa tatgttttct
     2701 gttggtgttg gaaattatga aaacttaaaa aaagcaaatt tagttgtaga ttcaacaaat
     2761 caattaaagt ttgaatatat acaagaaaag tataatgagt atatagttag gagaattata
     2821 tgaaatgttt atttagtaat gtagatgagt ggaagattat acaagataag attgaaatca
     2881 aagaaaatag attagcagag tccataatga gtataggcaa tggatatatg ggtatgagag
     2941 gaaactatga ggaaaattat agtggagata cacacaaggg gtcttatata gctggagtat
     3001 ggtttccaga taaaactcgt gttggttggt ggaaaaatgg gtatccagaa tactttggta
     3061 aaattcctaa ttcagtcaac tatataggtg taagaatttt catagatgat gtagaattag
     3121 atttagcaaa atgtaaagta gaagattttt atagagaatt agatatgaaa aatggtattt
     3181 taaatcgtag gtttattgta aatataaatg ataaaaaatt tgaagttagg gttgctaggt
     3241 ttttaagtat atctgttaag gaacttgcag taattaaata cagtataaaa tcattaaatt
     3301 ctaatactaa aataaaattt gtaccatatt tagattcaaa tataaaaaat gaagattcaa
     3361 actatgagga aaagttttgg aatggaattt cttcaagttc tttagaatat aaagggagta
     3421 ttctttctcg aacaaaggag aatgcattta atacaccagt attcactgtg ggttcaatga
     3481 tgtatattaa gacaaatggt gatgtagaag ctatatctca tgagagtgat tataattact
     3541 gtgaaaattc gataacaatg gatgttttaa aaaatgaggt tgcaagtata gaaaaatatg
     3601 tatctataac ttcaactaga gattataagg aaagtgagct attaagaaaa tgtgaagaca
     3661 ttttaaatag agaactatct aaaagttatg atgatatatt aaatgaacat acaaagttat
     3721 ggaataaaag atgggaaagt gcagatgtaa aaataaatgg agataaaagt agccaacaag
     3781 gtataagata taatttattc caactatttt caacatatta tggagaagat tcgcgattaa
     3841 atataggtcc aaaaggattt actggtgaaa agtatggagg agctacttat tgggatacag
     3901 aagcattttg tgttccagta tatctaggtg tagcagataa ggaggtaact agaaatcttt
     3961 tagaatatag gtacaatcag ttagaacagg caaaggataa tgcaaaaaaa ctagggctta
     4021 aaggtgcttt atatccaatg gtaacatttg atggagtaga atgtcataat gaatgggaga
     4081 taacatttga ggaaatccac cgaaatggaa gtatagtata tgcaatatat aactatacaa
     4141 attatacagg tgactataaa tatataaaag aaaaaggaat agatgtaata atagaaatag
     4201 ctagattttg ggcaagtaga gttcatttgt ctacaaaaaa agatttgtat atgatacatg
     4261 gagtaacagg tccaaacgag tatgaaaaca atatcaataa taattggtat actaattata
     4321 tagctaaatg gtgtttagat tatgctgtag aaaatatctt acgattagag aaagagtgta
     4381 atgaatgtat tgacagaaat aatgtgacta gggaagaagt tgagttttgg aaaataatat
     4441 caaataaaat gtatctgccg tatgatgagg aactacaaat aataattcaa aatgataatt
     4501 ttttagataa agaatttgta gaagtaaagg atttaccaaa agaaaatttt cctcttaatc
     4561 aaaattggtc ttgggataag attcttaggt cgtgttttat aaaacaagca gatgtattac
     4621 agggaattta ctattttgga aatagattta ctaaagaaga aaaaaagaga aattttgact
     4681 tctatgaaaa atatactgta catgaatctt ctttatcttc tagtatttat tctattattg
     4741 cctcagaaat agataaccta gaaaaggctt atgaattata ttcaagaaca gctaggcttg
     4801 atttagataa ttacaataat gatacaaatg atggactgca cataacttca atgtctggtt
     4861 catggctttc cattgtacat ggatttgcag gcatgagaac atggaatgaa actctatctt
     4921 ttgaccctaa gttgccaaaa gagtggaaaa attattcttt caatataaat tatagagata
     4981 atattattaa tgtagatgta tgtagtgatt taattaaaat agaaaattta aaaggtagac
     5041 caataaaaat tattgtatat gggaaaaaat atatattaga aaaa
//
LOCUS       DAEQCW010000173         5071 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.174, whole genome shotgun sequence.
ACCESSION   DAEQCW010000173 DAEQCW010000000
VERSION     DAEQCW010000173.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5071)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5071)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5071
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.174"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            57..860
                     /locus_tag="KRO40_003429"
     CDS             57..860
                     /locus_tag="KRO40_003429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094223.1"
                     /translation="MEKLRVIEMIKNNPNIIATIDNPTDEMKLLAIKENGLVLEYINN
                     PTREMQELAIDNNIRAIKFIDNPTEDMMIKAVNEGWSILDYIKNPTDKVIEMAINQAG
                     WAIKYAKNPSEELQLLAVRKNYDSIKFIKQPYESVQEEAVRISYDALRYIDSPSYNAE
                     LIAIKNNEAAISFITDLDKNKMLEFLKVNILVIKYILKKVSKDELESVLKEVLSKEDV
                     EEKYIRDFLNCSVIDRNSESIPIDKIMFIYKYGSKTAKKIAVDEKLKIM"
     gene            872..2002
                     /locus_tag="KRO40_003430"
     CDS             872..2002
                     /locus_tag="KRO40_003430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2094224.1"
                     /translation="MNFIDTLKSVDLILSTGEVPLIVGESGIGKTALANKLAKENDWS
                     LIVIDGNLLKEGEIGGLPTIESYVGVNSNGYKTEKKTTVYAVHNKLREIDEEISKSKT
                     VLLFIDEINRCEHTVQQELMNLILNREINGYKLHDDVKILAAMNPSSKYGSDFDYQVV
                     DMDAAQENRFVWLNMESDHTQWIKWAIDEGIERKVIEFISTFPEYLHKINEDDVRATP
                     RSYERVSKIYKVYKEKNNSIPRAVFLNVVKGNVGKVIAEEFISFIESNSEPLISYEDV
                     FLGESIDESIVERVKNESHTRLYLSAMNILKDLELNIKNDKYESNHYINRFIEFLKMY
                     PVDLMIGIMKDIRNSYIEVYKKAIENEEFVKSYFESYSLIRG"
     gene            2006..3427
                     /locus_tag="KRO40_003431"
     CDS             2006..3427
                     /locus_tag="KRO40_003431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094225.1"
                     /translation="MENYFDKQAKELYNKASEIINTHSMLKANRANEKFDIDIPQDFK
                     YEFFSLVDKVNLSLMEEEDNFYGYFLFQMSREIRFDISSPTGVNFKGAKYIIYFNPII
                     FLTLDIKQMETTIKHEIHHILSMHLMRAKELKGKYSTLAINMAMDIVVNKFLNNLPPY
                     ATTLEWVNLKYSLKLEPYEPFEYYVEKIQTELDLMEVDEDGEEDGEEDDSDKYGDIEI
                     DYSPERTHDIWDESNEIDENTLREFTEKFINSSQKGKVPAYLESMISSLKNSKGELPW
                     NLYLNRIMGTVENNKKKTITRRNRRQPNRLDLRGELRSHKSEIAVALDVSGSISDEEF
                     KQAIKEVLSIVKNYNHEITIIECDNEIRRVYKVRTEKDIKDRIRIGGGTRFSPVFEYA
                     NNKKINLLVYFTDGKGENKLQVIPRGYKILWVISGRGDKISLKEPYGAVKKLTKVKTN
                     DEILEINDVRNDGYSMNSQAPIL"
     gene            3638..4147
                     /locus_tag="KRO40_003432"
     CDS             3638..4147
                     /locus_tag="KRO40_003432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBH2094226.1"
                     /translation="MVMFLFKIDDYIMYGMTGVCKVMDITNERFTNGIKKEYYVLSPI
                     YSNNTVIKIPVDNEKVPMRKLLSKINVLSLINDIPNMDTSWIDNEKLRSEQFKKILRG
                     GKCEELIKLVRSIDNNREYVKSIGKKTHQADDNIMKEAERLLNEEFATILDISPNEVS
                     SYISSHIPQ"
BASE COUNT         2116 a          426 c          867 g         1662 t
ORIGIN      
        1 atagattatt ataattaata tagatataaa aataattata gaaggaaagg cacattatgg
       61 aaaaattgag agttattgaa atgataaaaa ataatcccaa tattatagct acaatagata
      121 atccaactga tgaaatgaaa ttgttagcta ttaaagaaaa tgggcttgta ctagaatata
      181 taaataatcc aaccagagag atgcaagaac tagcaataga taataatatt agagcaatta
      241 aatttataga taatccaaca gaagatatga tgataaaagc agtaaatgag ggatggagta
      301 tactggatta tatcaaaaac ccaactgata aagttattga aatggctata aatcaagcag
      361 gatgggcaat taaatatgct aaaaatccaa gtgaagaatt acaactgtta gcagtaagaa
      421 aaaattatga ttcgataaag tttataaaac aaccttatga aagtgtacaa gaggaggcag
      481 tgagaataag ttatgatgcc ttgagatata tagattcacc tagttataat gcagaactta
      541 tagctataaa aaataatgaa gcagctatta gctttataac tgatttagat aaaaataaaa
      601 tgttggaatt tttaaaagtg aatattttag tgattaagta cattctgaaa aaagtatcta
      661 aagatgaatt agagagtgta ttaaaagaag tattatccaa agaagatgtt gaggaaaagt
      721 atattagaga ttttttgaat tgtagtgtta tagatagaaa tagcgaaagt ataccaatag
      781 ataaaattat gtttatttat aaatatggaa gtaagacagc aaaaaaaata gctgtagatg
      841 agaaattaaa gattatgtag gagagagaaa aatgaatttt atagacacat taaaaagcgt
      901 tgacttaata ttatccactg gagaagtacc tttaatagta ggtgaaagtg gaataggaaa
      961 aacagcttta gcaaataagc ttgccaaaga aaatgattgg agtttaattg ttattgatgg
     1021 aaacttactt aaagagggtg aaataggtgg tcttccaact atagaatctt atgtaggagt
     1081 taattctaat ggatataaga ctgaaaagaa aacaacagtg tatgctgttc ataacaaatt
     1141 aagagaaatt gatgaagaga tatctaaaag taagacagtt cttttattta tagatgagat
     1201 aaatcgttgt gagcatacag tacagcaaga acttatgaat ttaattttaa atagagaaat
     1261 taatggatat aaactgcatg atgatgtaaa gattttagca gcaatgaatc catcaagtaa
     1321 atatggttca gattttgatt atcaagtggt agatatggat gcagcccaag aaaataggtt
     1381 tgtttggtta aatatggaga gtgaccatac acaatggata aaatgggcaa tagatgaggg
     1441 tattgaaaga aaagttatcg agtttatttc cacttttcca gaatatctgc ataaaataaa
     1501 tgaagatgat gtaagagcca ctcctagaag ttatgagaga gtatctaaaa tttataaagt
     1561 ttataaagaa aaaaataatt ctattcctag agcagtattt ttaaatgttg taaagggtaa
     1621 tgtaggtaaa gttattgcag aagaatttat aagttttatt gaatcaaact ctgaaccatt
     1681 aatatcctat gaagatgttt ttttaggaga atctattgat gagtctattg tagaaagagt
     1741 aaaaaatgag agtcatacaa gactttatct atcagctatg aacattctaa aagacttaga
     1801 attaaatatt aagaatgata aatatgaatc aaaccactat attaatagat ttattgaatt
     1861 tttaaaaatg tatcctgtag atttaatgat aggtattatg aaggatatta gaaacagtta
     1921 tattgaagta tataaaaaag ctatagaaaa tgaagagttt gtaaaatcat attttgaatc
     1981 ttatagttta ataaggggat aatgtatgga aaattatttt gataaacaag caaaagagct
     2041 ttataataaa gcaagtgaaa ttataaatac tcattctatg ctaaaggcaa atcgtgctaa
     2101 tgagaaattt gatatagata taccacaaga ttttaagtat gagtttttta gtcttgtaga
     2161 taaagtgaat ttaagtctta tggaagaaga agataatttt tatggatatt ttttgtttca
     2221 gatgtcaaga gaaataagat ttgatataag tagtcctaca ggtgtgaatt ttaagggagc
     2281 taaatatatt atatatttta atccaataat ctttttaacg cttgacataa agcaaatgga
     2341 gactacaatt aaacatgaaa ttcatcatat attatctatg catttgatga gagcaaagga
     2401 gttaaaagga aagtatagta cattagcaat taatatggca atggatatag tagtaaataa
     2461 atttctaaac aatttaccac catatgcaac taccttagag tgggtaaatt taaaatattc
     2521 cttaaaactt gaaccatatg aaccttttga atattatgta gaaaagattc agactgaatt
     2581 agatttgatg gaagtggatg aagatggtga ggaagatggt gaggaagatg atagtgataa
     2641 atatggagat atagaaattg attatagccc cgaaagaact catgatatat gggatgaatc
     2701 caatgagata gatgaaaata cccttagaga atttactgaa aaatttatta acagttctca
     2761 aaaaggtaaa gttcctgctt atttagaaag tatgatatca tcacttaaaa atagtaaggg
     2821 tgaattgcca tggaatttat atcttaatag aataatggga acagttgaaa ataataaaaa
     2881 gaagactata acaagaagaa atagaagaca accaaatcgt ttagatttga ggggagaact
     2941 tagaagtcat aagtcagaaa tagcagttgc acttgatgta agtggaagta ttagtgatga
     3001 agagtttaaa caagctatta aagaagttct tagtatagtg aaaaactata atcatgaaat
     3061 tacaattata gaatgtgata atgaaattag acgtgtatat aaagtgagaa ctgaaaaaga
     3121 tataaaagat agaattagga taggtggagg tactagattt tctccagtct ttgagtatgc
     3181 taataataaa aagattaatt tgttagtcta ctttactgat ggtaaaggtg aaaataaact
     3241 acaagtaata cctagagggt acaaaatttt atgggttatt tctggaagag gagataaaat
     3301 ttcattaaaa gaaccttatg gagcagttaa aaaacttact aaggttaaaa caaatgatga
     3361 aatattagaa ataaatgatg taagaaatga tgggtactca atgaatagcc aagcaccaat
     3421 tttataggta ttcacaggag ataagctgta ttaatttatt ttgatatgct tgttataaaa
     3481 atctaaaaaa tacattaatc aatggttaat gtatttttta attttaataa tataagtttt
     3541 acttacattt aagtctcaaa atgtgttaaa atataatata tagcagatag ttttggcaag
     3601 gtggatttag ttgtcaaaac tatttttttt attaaggatg gtgatgtttt tgtttaagat
     3661 tgatgattat ataatgtatg gtatgacagg agtctgcaaa gtcatggata taacaaatga
     3721 acgatttaca aatggaataa aaaaagagta ttatgtattg agtcctattt attctaataa
     3781 tacagtaata aaaattcctg tagataatga aaaagtacca atgagaaagt tactttctaa
     3841 aattaatgtg ctttcattaa taaatgatat tcctaatatg gatacatcat ggatagataa
     3901 tgaaaaattg agaagtgagc aatttaaaaa aatactcaga ggtggtaaat gtgaagagtt
     3961 aataaaatta gtaagaagta tagataataa cagagagtat gtaaaatcta ttggtaaaaa
     4021 aacacatcaa gcagatgata atataatgaa agaagctgaa aggttattaa atgaagaatt
     4081 tgcaactatt ttagatattt ctcctaatga agttagttca tatatttcaa gtcatatacc
     4141 tcaataaagt gttttagtat cctttattta atctatttta agtattattt atgtatgctg
     4201 gttttggtaa aataaaatat ataattaaat tatataaaaa ataataatga ttgtattgaa
     4261 gaattacaga atagtgcgga gagcctactc ctttaggtgt gagatggata tcacttaaag
     4321 atttaaattg ttattgtaga tgtttttaat ataaaacaag attaataagt gtattgtaag
     4381 ctttaagtga aattgatact ataatgagtt acttagattt taaaatatat aatattataa
     4441 aaaatccttt taggttttga atgaataaga tggatactat gttgaataga atccatctta
     4501 tttaagtttt atttatgttg tttatttgta agcattattt ttgtacatga aaacacagtg
     4561 taaaaatatg cttagaatta tgaagtttta ttaaaaagat attcgacaaa ataagactaa
     4621 aaatattctt aaacttataa ctaagataaa tattgtatat ttatagtgta gcctgaaaaa
     4681 ttgtggatgt acgaaattta tttagtattt tattgaaaca aagtagaaga agtactatag
     4741 tttatctttg aatagattgt tattttttag tgaaaaagtt attaggttaa tacataaata
     4801 taatagctta taaatagttt aagcatgtta aaaaagtagt tattagagat atatagttac
     4861 attgcttata agatacttaa aatgatagca ttcacttata ttcagaagat taagataaaa
     4921 aatcattttt atatagtaaa gcatacctaa atttagaaaa taattgaatt tataaaatta
     4981 attaaataca taaaaaagta ttcaatcaac ttaacaaatt ttcttaaatt taatttaaat
     5041 tttttattct attaattatt aatattattt t
//
LOCUS       DAEQCW010000174         5038 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.175, whole genome shotgun sequence.
ACCESSION   DAEQCW010000174 DAEQCW010000000
VERSION     DAEQCW010000174.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5038)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5038)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5038
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.175"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..1181)
                     /locus_tag="KRO40_003433"
     CDS             complement(<1..1181)
                     /locus_tag="KRO40_003433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBH2094227.1"
                     /translation="MKSYTKAKWSVWGIITFSFVLVLFLRMSTAVVSDNLANELGFNS
                     IQISNIASFCLYAYAFMQIPAGILIDKYGARKISSLGIIMASLGSILFGLIQSIELAY
                     ISRVIVGAGTSVILLCILKIQGRWFNKSEFASATAKFSFVGNLGGVLATFPLVFLSEL
                     VGWRNSFLLIGIIGVVIGCFMYIIVRDTPKEYGFNVDTEPYENSEKVNIVDGIKSVIK
                     NKSTWYNSMIMFSFVGLTSAFISLWGVRYIMDVYGVSKSFSAFIVSFFTYGFIFGSII
                     MDFVFAKIRSSKFNIIKFGAMIDLFIWIVIVVVYQVKPPIIVLPISFFIMGCIVMSHL
                     QVFNDAKYKNKEIYSGLATSVINTFEFIGSGIINLIIAISLQVNSYNIVNGYKKGFVV
                     F"
     gene            complement(1403..2167)
                     /locus_tag="KRO40_003434"
     CDS             complement(1403..2167)
                     /locus_tag="KRO40_003434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094228.1"
                     /translation="MLGKLLKYELKASGRIFIPLYIAILIVAVFNGIFMNTNILQVQG
                     IGILVLTSLFMALGVLTIVVTIQRFRKNLLGDEGYLMFTLPVSTSSLILSKCITALIY
                     AVLSFIVAVFTFGVLMLFGTSGILLPEILDLFNTSFKWISENFLDILLLVVVMFISYS
                     SFILLLYTSISMGQLPKFNKHRNIVAFASFIAINIVISIVGDAVGSILPNEDTNMVYH
                     LYQSPSFMLAILGSLVVAIALFFATKFILDKKLNLE"
     gene            complement(2161..2886)
                     /locus_tag="KRO40_003435"
     CDS             complement(2161..2886)
                     /locus_tag="KRO40_003435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094229.1"
                     /translation="MDKNISNVSQDGIVEFKGVNKSYGTKNVLKNIDLNIPKGKIVGL
                     LGPNGSGKSTMIKLMNGLLQPDNGEIMINGMKPSIDTKKIVSYLPERTYLNDWMKVSD
                     LLKFFYDFYSDFDVRRANEMIKSLDIDVNEKLKTMSKGTKEKVQLILVMSRNASIYIL
                     DEPIGGVDPAARSYILKTILKNYSEDSTLLIATHLISEIENICDEIIFISKGEIVLQG
                     DVEAIREEKGKSIDALFREEFKC"
     gene            complement(2888..3256)
                     /locus_tag="KRO40_003436"
     CDS             complement(2888..3256)
                     /locus_tag="KRO40_003436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2094230.1"
                     /translation="MEWELDNNKPIYIQLVEHLKLKIISGEIKIGSKLETVRALAEDA
                     EVNPNTMQKALTELERQGLVYSQRTKGRFVTDDKEKIKAMKEEIANVEINTLKITLEK
                     LGYDRDEMLKLITENLKGEL"
     gene            complement(3432..4976)
                     /locus_tag="KRO40_003437"
     CDS             complement(3432..4976)
                     /locus_tag="KRO40_003437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH2094231.1"
                     /translation="MRNLQKKLMFFLFICIILQITYTTPVYSLCKLYKNNSINNFESI
                     VSNNQLISKHAIQIILIMAIICVILIFYIIYDKLNFKIKLQRIAYTDNLTGANTIDKF
                     VIDANKILCKNTQVKYALLYIDIDKFKYINDLFGYEVGNEILRNLTKIIKRNIFEEEM
                     FARISADNFIIIMKYIEEEDITKRLKTIFEELDLFNNNQEEKYKLVLSCGIYFILPED
                     RDINSIIDRANIPHKMAKGGHKSSYAFYDNKIHDQEIKEKEMENTMFSSLENKEFIIY
                     LQPKIELNTGEIQGSEALVRWKRPDKGLIPPNEFIPFFERNGFVINLDLYVLEEVCIY
                     LRKWIDAGINPVTVSVNVSRIHLYCNNFIETYKNIIDKYNIPAKYIELELTESIIFDN
                     FDILIDIMNNLKKIGFLISMDDFGSGYSSLNMLKEIPMDILKLDQKFIMETYNSKRSK
                     IIVTKVIEMAKELGMKVISEGVETEEQFKLLKEVKCDMAQGYLFGKPMPIEEFEHLIV
                     SNLIRG"
BASE COUNT         1769 a          855 c          475 g         1939 t
ORIGIN      
        1 ataaatacta caaaaccttt tttatatcca ttaactatat tatatgaatt tacttgtaaa
       61 gagatagcta taatcaaatt aataattcca cttcctataa attcaaaagt attaataaca
      121 ctagttgcca gtccagaata aatttcttta tttttatact tggcatcatt aaaaacctgt
      181 agatgtgaca taactataca tcccataata aagaatgata ttggtaaaac tataattggt
      241 ggttttacct ggtatacaac tacaattaca atccatataa acaaatctat cattgcccca
      301 aattttatta tattaaattt gctagacctt attttagcaa atacaaaatc cataattatt
      361 gaaccaaata taaatccata tgtaaaaaag gatactataa acgcagaaaa actcttactc
      421 acaccataaa cgtccattat gtatcttact ccccacaagc ttataaatgc acttgtaaga
      481 cccacaaaag agaacattat cattgaatta taccatgttg atttgttctt tataacagac
      541 ttaataccat caacaatatt aaccttctct gaattttcat agggttcagt atctacattg
      601 aatccatact cttttggtgt atctctaaca ataatataca taaaacatcc aattacaaca
      661 ccaattatac cgattaataa aaatgaattt ctccaaccaa caagttcaga caaaaacaca
      721 agtggaaaag tagcaagaac tccacctaaa tttcctacaa atgaaaattt agctgttgca
      781 gaagcaaatt ctgacttatt aaaccatctc ccttgaattt ttaaaataca aagtaatatt
      841 actgatgttc ctgcccctac aattacacga gaaatatatg ctaattctat actttgaatc
      901 aaaccaaata aaattgaccc taaacttgcc attattattc caagactgct aatttttctt
      961 gctccatatt tatcaatcaa aattcctgca ggtatttgca taaatgcata tgcatatagg
     1021 caaaaggatg ctatatttga aatttgtata gaattaaaac ctaactcatt tgctaaattg
     1081 tctgaaacaa cagcagttga catccttaaa aataatacta aaacaaatga aaatgtaatt
     1141 ataccccaaa cactccactt agcctttgta taacttttca tatcttctcc ctcaaatcca
     1201 tatattttta aattttcttg atataactta tataaagtgt atagttattc ttacaaattt
     1261 ttacacgcaa tatcattata caacatatgt atatatttaa ctagaaataa aacactattc
     1321 atattatata catgaattaa ctacataaat aataagagcc atcttttaac attactcaaa
     1381 agatggctcc atataaaaac atttattcta aatttaattt tttatctaat ataaattttg
     1441 tagcgaaaaa taacgctatt gcaactacaa gactaccaag tattgcaagc ataaaactag
     1501 gactctgata aagatgatat accatatttg tatcttcatt tggtaagatg cttccaactg
     1561 catctccaac aattgatatt actatattta tagctataaa agaagcaaat gccactatgt
     1621 ttctatgttt attgaatttt ggtaattgtc ccattgagat tgatgtatat aataacaaaa
     1681 taaatgatga atatgaaata aacattacta ctactaataa taaaatatct aaaaagtttt
     1741 cagaaatcca tttaaaacta gtgttaaaca aatctaaaat ttcaggtagt aaaattccag
     1801 aagtaccaaa aagcataaga actccaaaag tgaatactgc aactataaaa ctaagtacag
     1861 cgtatataag tgctgttata catttagata atataagtga actagtgcta acaggaagag
     1921 taaacattaa ataaccttca tcccccaaaa gattttttct aaacctttga attgtaacta
     1981 caatagttaa aactcctaat gccataaaaa gacttgttaa tactagtatt cctattccct
     2041 gtacctgaag tatatttgta ttcataaata ttccattaaa tacagctact atcaatatgg
     2101 ctatatataa cggtataaat attcttccac ttgcttttaa ctcatatttt aataatttac
     2161 ctaacattta aattcctccc taaataatgc atctatagat tttccttttt cttctcttat
     2221 tgcttcaacg tctccttgta acactatttc tccttttgat atgaatatta tctcatcaca
     2281 tatgttttct atttcactta ttaagtgggt agcaatcagt aaagtactat cttcagaata
     2341 attttttaat atagtcttaa gtatatatga ccttgcagct gggtcaacac cacctatagg
     2401 ttcatccaat atatatatgc tcgcatttct tgacattact aaaataagtt gaactttttc
     2461 tttagttcct ttagacattg tctttagctt ttcatttaca tcaatatcta agcttttaat
     2521 catctcattt gctcttctaa catcaaaatc actataaaaa tcatagaaaa acttaagtaa
     2581 atctgatacc ttcatccaat catttaaata agttctttct ggtaaatatg aaactatttt
     2641 tttagtatct atggatggtt tcattccatt tatcataatt tcaccattgt caggctgtaa
     2701 taatccattc attagcttaa tcattgtact tttgccactt ccattaggtc ctaacagccc
     2761 gactattttt ccctttggta tatttaaatc aatatttttt aaaacattct tagttccata
     2821 actcttgttt acacctttaa attcaactat tccatcttga gaaacattgc ttatattttt
     2881 atccatttta taattctcct ttcagatttt ctgtaataag ttttagcatt tcatctctat
     2941 catatccaag cttttctaag gttattttta atgtatttat ctccacatta gctatttcct
     3001 ctttcatagc ttttattttt tccttatcat ctgttacaaa tcttccttta gttctctgac
     3061 tataaactaa accttgtctt tcaagttctg ttagagcctt ttgcattgta tttggattaa
     3121 cttccgcatc ttctgctagt gctctcactg tttctaattt agatcctatt ttaatttccc
     3181 ctgaaattat ttttaacttt aaatgttcta ctaattgtat atatataggt ttgttattat
     3241 caagttccca ttccatgttc atgcctcctt attatattat tgtattaagt tgttaataca
     3301 ataatataat aatacaaagt atatgtcaat tactttttag taaaagtata aaaaatttta
     3361 caaaaaaaat gaacactaca ttagagtcca tttttaacac aatttattaa attctttata
     3421 ttacagatta attaccctct tatcaagttg gatacaatta aatgttcaaa ttcttcaatt
     3481 ggcattggct ttccaaataa atatccttgt gccatatcac actttacttc ttttaaaagt
     3541 ttaaactgtt cttctgtctc aactccttct gatatgactt tcatacccaa ctcttttgcc
     3601 atttctatta ctttagtaac aattattttg cttcttttac tattataagt ttccataata
     3661 aatttttggt caagttttaa gatatccata ggaatttctt ttaacatatt taatgatgag
     3721 taccctgaac caaaatcatc catagatatt aaaaatccta ttttttttaa attattcatt
     3781 atatcaatta aaatatcaaa attatcaaat atgatactct ccgttaattc aagttctata
     3841 tactttgcag gtatattgta tttatcaatt atatttttgt atgtttctat aaaattattg
     3901 caatataaat gtatccttga aacattaact gaaacagtaa ctggatttat tcctgcatca
     3961 atccattttc taaggtatat acatacttct tcaagcacat ataaatctaa atttataaca
     4021 aaaccgtttc tttcaaaaaa tgggataaat tcatttggag gtattagccc tttatcagga
     4081 cgtttccacc taacaagtgc ttctgaacct tgtatctctc ctgtattaag ttctatctta
     4141 ggttgtaagt atataataaa ttctttattt tctagacttg aaaacattgt attttccatc
     4201 tctttttctt ttatctcttg gtcatgaatc ttattatcat aaaatgcata tgaactttta
     4261 tgtcctccct ttgccatttt atgaggtata ttagccctat ctatgattga gttgatatct
     4321 ctatcttctg gaagtataaa atagattcca caacttaaaa ctaacttata tttttcttct
     4381 tgattattat taaacaagtc taattcttca aatatagttt ttaacctctt tgttatatct
     4441 tcttcttcta tatatttcat aattataata aaattatccg cagatattct tgcaaacatt
     4501 tcctcttcaa atatattcct cttaataatc tttgttaaat tacgcaaaat ttcattccca
     4561 acttcatatc caaataaatc atttatatat ttaaatttat caatatctat atataataaa
     4621 gcatacttta cttgagtatt tttacatagt attttgttag catcaattac aaatttatct
     4681 atagtatttg ctcctgtaag attatctgta tatgctatcc tttgcaattt aattttaaaa
     4741 tttaatttat catatattat atagaatata agtattacac atattatagc cataataagt
     4801 attatttgta ttgcatgttt gctaataagc tgattattag acacaataga ctcaaagtta
     4861 tttatggagt tgtttttata gagtttgcat aaagaataga ctggtgttgt gtatgtaatt
     4921 tgtaaaatta tacaaataaa taaaaaaaac atcaattttt tttgtaaatt cctcataaaa
     4981 atttcctccc attaaaacac ctctatttta ttagcaaata agtacatctc aaaagttt
//
LOCUS       DAEQCW010000175         5018 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.176, whole genome shotgun sequence.
ACCESSION   DAEQCW010000175 DAEQCW010000000
VERSION     DAEQCW010000175.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5018)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.176"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            613..843
                     /locus_tag="KRO40_003438"
     CDS             613..843
                     /locus_tag="KRO40_003438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2094232.1"
                     /translation="MSNKKKKYANILANECVACGSCIKACPRSAISVPCGISAKINRD
                     LCVGCGICEKICPASVIEIITILKEEEGKCHE"
     gene            836..1417
                     /locus_tag="KRO40_003439"
     CDS             836..1417
                     /locus_tag="KRO40_003439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBH2094233.1"
                     /translation="MNNKKHWYDYLWIFSSIYLILGFVNIIFAWIGLICFFVPLAISI
                     VKGNKAYCNKYCGRGQLFNLLGNKLKLSRNRDIPKFIRSKWFRYGFLTFFMVMFANML
                     FSTYLVFEGSRNFKEVVTLLWTIKMPWQWAYHGTLVSPWVVQFAFGFYSVMLTSTVLG
                     LITMILFKPRSWCVYCPMGTMTQMICKAKSKSV"
     gene            complement(1995..2672)
                     /locus_tag="KRO40_003440"
     CDS             complement(1995..2672)
                     /locus_tag="KRO40_003440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBH2094234.1"
                     /translation="MISQNEIDILTHSLPFWDKLTDLQKELLISSANTSHYKKGNPVH
                     CGDSDCIGILIIKSGTVRTYILSDEGREVTLFRLDDGDVCILSASCILKTITFDVYVD
                     AETDCDIIQISSSVFAKLSTENIHAELFSYKLATERFSDVMWAMQQILFMSFDKRLAS
                     FLIDEIAKNGSNTINMTHEQIAKYMGSAREVVSRMLKYFAREGIVSLSRGGIKVLDKD
                     KLRSLTL"
     gene            complement(2861..4225)
                     /locus_tag="KRO40_003441"
     CDS             complement(2861..4225)
                     /locus_tag="KRO40_003441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2094235.1"
                     /translation="MKESDKRIELLGSAPISKALLSMGLPTMIGMMITALYNLVDAYF
                     VGGLGTSQMGAISVAFPLGQLVVGLGLLFGNGAASYIARLLGHGDNEKAGKVVSTSIY
                     SSIIVGTLVIIVIMIFLNPILKLLGATKSIMPYAISYASIYVVSSIFNIFNVTMTNIV
                     TSEGAAKTTMCAMLLGALLNMILDPIFIYTFGLGVRGASIATAISQIASTLVYVGYIL
                     SKKSIFSFRINECCFSKEIFSEILKIGIPTLIFQLLTSLAITLTNMEATKYGDSVIAG
                     MGAVTRITSLGSLVVFGFIKGFQPIAGYNFGSKNYDRLHIAIKTSILWTTVFCVVLGL
                     ILILFPKSIISQFTSGDILLIENGSKALRANGFSFMLFGFYTVYSTLFLALGKAKECG
                     FLGMCRQGVCFIPIILIIPVFYGLNGILYAQPIADLMAAIIAGFMSIRLHKELNLLKI
                     NGMH"
     gene            4353..4874
                     /locus_tag="KRO40_003442"
     CDS             4353..4874
                     /locus_tag="KRO40_003442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBH2094236.1"
                     /translation="MATIDLIVLGIVKQQPKSAYDIQKAVEYRNISRWVKISTPSIYK
                     KVIQLEQKGYIESKTVKNGKMPEKAVYSLTELGETHFLDLMFDTSSKPINILLDFNAV
                     IVNLNSLTPEKQKLCLNNIEENVQELKKTIEENISIKTEVPETAKAVLEQQLVLAQAL
                     ETWINSLKDNMGN"
BASE COUNT         1901 a          650 c          803 g         1664 t
ORIGIN      
        1 gtttaacttg tggttaatag agtaagaatg taaatagaga taaacttcaa tatgagctta
       61 acttgtgatt aatagagtaa gagtgtaaat agagataaac ttcaatatgg gattaacttg
      121 tgattaatag agtaagagtg taactaaaga taaacttcaa tatgagctta acctatgatt
      181 aatagagtaa gaatgtaaat agagataaac ttcaatatgg gtttaacctg tggttaatag
      241 agtagggtgt aactaaagat aaacttcaat atgagtttaa cttgtggcta atagaataag
      301 attgtgaata aagttatagt tttagatggg tattaacctg ttactaatag aatatgatta
      361 ggtgtaaaat tatagagctg tataagaaaa tattatagat atattaaata ttagataata
      421 aatatttata tagatacaca aaagaaaagg cgatatgaag ctaaacttaa tgacttcata
      481 tcgtttttta tttgaaactc ctttgtattt agagtgtgat ttttaatatt gaggttttat
      541 gtgattaagt cacagataaa aagtaagtat cttgatataa ttcttataga ttaataatat
      601 agggaggtta ttatgtctaa taaaaaaaag aagtatgcaa atattttagc aaatgagtgc
      661 gttgcttgtg gtagctgtat aaaagcatgt ccaagaagtg ctatctcagt tccatgtggc
      721 attagtgcaa aaattaatag agatttatgt gttggatgtg ggatttgtga aaagatatgt
      781 ccagcatctg taattgagat tataacaata ttaaaagagg aagaaggtaa gtgtcatgaa
      841 taataaaaaa cattggtatg actatttatg gattttttct tcaatatatt tgatattggg
      901 atttgtaaat attattttcg cttggattgg gctaatttgt ttctttgttc cactagctat
      961 ttctattgtt aagggaaata aagcttactg taataagtat tgtggaagag ggcaactgtt
     1021 taatttgctt ggaaataaat tgaagctgtc aagaaataga gatattccta aatttattag
     1081 aagtaagtgg tttagatatg ggtttttgac attttttatg gtaatgtttg ctaatatgct
     1141 tttttcaact tatttagtgt ttgaaggaag tagaaatttt aaagaagtag tgactttgtt
     1201 gtggactata aaaatgcctt ggcaatgggc gtatcatgga actttagttt caccttgggt
     1261 ggtacagttt gcatttggtt tttatagtgt tatgcttaca tcaactgttc ttggtttgat
     1321 tactatgata ttgtttaaac ctcgttcatg gtgtgtttat tgccctatgg gtactatgac
     1381 tcagatgata tgtaaggcaa agagtaagtc tgtatagaaa ggccttatgt gatatttaca
     1441 gttttgttca agtagagatg agtagtaggt ttgaatatat atgacaaata tatgagtata
     1501 ggggcataga tttagtttgt gtaaggcaaa ctgatttatg cttctttttt atgtcttaga
     1561 ttattggcta agtagaaaca atgaatttag atattaagaa ttattcagtt atttgaagaa
     1621 aatagaataa taattaacat tatatgaatg gatattcatt acatataagc agttaatagc
     1681 aagatttatt taatatgaaa taggtcaagt atttaaacta aataaggtca tgacaattaa
     1741 tataagtata gatataaaaa gattagaagt tataacttat aaaaggtatt ctatataagt
     1801 agtatgtgga aaatagtcaa attaacttat tagaaacaaa aaatatacat aaaaaataaa
     1861 tgtaaatatc aaataagata ctatataaaa atagatataa gtatcttttt tattattgaa
     1921 attatgaaaa tatattttat tttacacaaa aaagagtgcc tcatgaacta aaaagttcat
     1981 tttgagacac acttttacag tgtcaaagaa cgaagtttat ccttatccaa tacttttata
     2041 ccaccacgag ataaagacac aataccttct ctagcaaaat atttcaacat tctcgataca
     2101 acttctctgg cactacccat atacttagca atttgttcat gagtcatatt tatagtgtta
     2161 ctgccatttt tagctatctc atcaattaaa aaagatgcca aacgcttatc aaaactcata
     2221 aaaagaattt gttgcatagc ccacataaca tcagaaaaac gttcggtagc taatttatat
     2281 gaaaataact ctgcatgaat attttctgta gataattttg caaaaacaga ggaactaatc
     2341 tgtataatat cgcagtccgt ttcagcatct acatagacat caaaagttat tgtttttaga
     2401 atacaggaag ctgataaaat acatacatct ccatcatcaa gtcggaacag tgtaacctct
     2461 cgaccttcat ctgaaagtat gtatgtacgc actgttccag attttataat caaaatacca
     2521 atacagtcac tatcaccaca atgtactgga ttcccttttt tgtaatgcga ggtatttgct
     2581 gaagaaatta ataattcttt ttgtaagtca gtaagtttat cccaaaaagg caagctatgt
     2641 gtaagtatat caatttcatt ttgtgaaatc atacaatatc tcctttctta aattgttata
     2701 atcccatgat acaagtgaat agataaattg acaagtagtt tgttaagagg attatttagt
     2761 cagatagtaa tagtatgatt tatgtagaaa aaatatgata atatatattc ttgctattaa
     2821 tgagaaagta atatgttttg atgatagtag gtttgtataa ctaatgcata ccgtttattt
     2881 ttaaaagatt aagttcctta tgtaacctta tagacataaa accagcaatt atagcagcca
     2941 tcaaatcagc tattggttgt gcatataaga taccatttaa cccatagaat acaggaataa
     3001 tcaaaattat agggataaaa cagacacctt gtctacacat acctaaaaat ccacattcct
     3061 ttgcttttcc tagtgcgagg aataatgtag aatacactgt atagaatcca aatagcataa
     3121 atgaaaaccc atttgcccta agagctttac taccattttc tattaataaa atgtcaccac
     3181 ttgtaaattg tgaaattata gattttggga agagtatcaa tataagacca agcactacac
     3241 aaaatactgt agtccataat atggaagttt ttattgctat atgtaatcta tcgtagttct
     3301 ttgaaccaaa attataacca gcaattggtt ggaaaccttt tataaaacca aatacaacaa
     3361 gactacctaa agatgttatt cgtgttacag cacccattcc agctatcaca gaatcaccat
     3421 actttgtagc ctccatatta gttaatgtaa tggcaagact agtcaataat tgaaatatta
     3481 aggtaggtat gccaattttt aggatttctg aaaaaatttc ttttgaaaaa cagcattcgt
     3541 taattctaaa actaaatata cttttcttgc ttaaaatata tcctacataa acaagtgttg
     3601 aagcaatctg tgagatagct gttgcaatag aagcacccct tacccccaga ccaaaagtat
     3661 aaatgaatat cgggtctaaa atcatattaa gcaaagcacc taataacata gcacacatag
     3721 ttgttttagc agctccttca cttgtgacaa tattagtcat agtgacattg aatatattaa
     3781 aaatagatga cacgacataa atgctagcat aagatattgc gtaaggcata atactttttg
     3841 tagctcctaa caattttaaa attggattga gaaaaatcat aatcacaata ataactaatg
     3901 tacccactat aatactactg taaatagatg tacttaccac ttttcctgct ttttcattat
     3961 caccatggcc taaaagtctg gcaatatatg aagcagctcc atttccaaac aataatccta
     4021 atcccacaac aagctgacct aatggaaatg caacggatat agctcccatt tgacttgttc
     4081 caagtccacc cacaaagtat gcatcaacca aattgtataa tgcagttatc atcataccta
     4141 tcatggtagg taatcccata gataacaatg cttttgagat tggggcagag cctaataatt
     4201 caattctttt gtcactttct ttcatactta acactcctct tctattgaca ttaagtctaa
     4261 attataatac tataaattat agtaagtatg gaaaatagta ctataattta tagtatttgt
     4321 caatagtaag aaaactaaag gagatgattt ttatggctac aatagattta attgtattgg
     4381 gaatagtaaa gcaacaaccc aagagtgctt atgatattca aaaggcagtg gaatacagga
     4441 atatatcacg ttgggttaaa ataagtacac catcaattta taaaaaagta attcaattag
     4501 aacaaaaggg atatattgaa agtaaaactg tgaagaatgg aaaaatgcca gaaaaagcag
     4561 tttattcatt aactgaatta ggtgagacac attttttaga tttaatgttt gatacatcta
     4621 gcaaaccaat aaatattctt ttagatttta atgctgttat agtaaattta aatagcctta
     4681 caccagaaaa acagaaatta tgtctcaata atattgaaga gaatgttcaa gagttaaaga
     4741 aaactattga ggaaaatata agtataaaga cagaagtacc agagacagca aaagcagtat
     4801 tggaacaaca gttggtgcta gcacaagcat tggaaacctg gataaattct ttaaaagata
     4861 atatgggaaa ttagaattag agaagctaac ttaataatca ttaaacaaaa accagcatat
     4921 ttaataatga gatattagaa aaaataaaac aaatgatata aactgaaaag tatatttaaa
     4981 ataaagctca cttaattgag ggagaatgtt aaactttt
//
LOCUS       DAEQCW010000176         4961 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.177, whole genome shotgun sequence.
ACCESSION   DAEQCW010000176 DAEQCW010000000
VERSION     DAEQCW010000176.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4961)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4961)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4961
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.177"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(547..1188)
                     /locus_tag="KRO40_003443"
     CDS             complement(547..1188)
                     /locus_tag="KRO40_003443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase"
                     /protein_id="HBH2094237.1"
                     /translation="MNNNFQDNQTINLIQSRRSIRKFTTEQISDEQVNTLLHCAFAAP
                     SGCNKQPWHITVVQDQKLLKEISDDTLSRIHEVSNVEINKNFKLFYGAPTVLFISYDE
                     SSSWAPYDIGILTGNITTAAQALGLGSCIIGMVRGLFTPVEQGDIEGLVSVLDKEDVK
                     ESESIKMKFDTNKKYRELLDIPEGYSVPFGIAVGIPDGNLPNAREVVYKVSRV"
     gene            complement(1431..2234)
                     /locus_tag="KRO40_003444"
     CDS             complement(1431..2234)
                     /locus_tag="KRO40_003444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBH2094238.1"
                     /translation="MNKKGFTLIELLVVISIIGILVIVAVPALFRNIEKSKAVTCLSN
                     RENIKTQIVIAMAEESSKGKNEVMKEVLENKDGKYFETEPKCKSGGIYSATFDDGYDG
                     ITGIESIAKVYVTCTKHPDGVEMARDIHQSMKDLIASFAQDPSIIPGASKGNDDFRKY
                     LLDNKYKNGWPTIPDEFKAKYGLSKDTLYIQPYAYSPTKSDATVVVFANNKTGGNWYT
                     SLVYDYDEGRWYKGKNGISVAGRSWDVDTDSVKSVKTEIHSKEGWGPLN"
     gene            complement(2390..3565)
                     /gene="thiI"
                     /locus_tag="KRO40_003445"
     CDS             complement(2390..3565)
                     /gene="thiI"
                     /locus_tag="KRO40_003445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HBH2094239.1"
                     /translation="MVYNILIVKYGEIGVKGKNRYIFENRLIRNIRNMLKPIGRFNVY
                     KEYGRIYVDLEDYDYEEVIEEVRKVFGIVGVCPGVRAKKDYDTLKEIALKMLEEKIEA
                     GYKTFKVESRRGDKSFGLTSQEMSMDIGGYLLSKVGDRINVDVRNPEVKIKCEYREFH
                     TMVYSDTIPGYGGLPLGTNGRAMSLLSGGIDSPVATWMVAKRGMEVEAVHFHSYPFTS
                     ERSQEKVKDLAKILAKYCGRVRLHKVNILEIQKAIGENCNEEEATILSRRFMMRIAQR
                     LSEKRHCDALITGESIGQVASQTIQGLTCTNAVVDLPVFRPLIAMDKSDIVDIAKKIG
                     TFETSILPEEDCCSVFSPRKPVTKPRLEKIEKSETALDIEKLVQDAIDKIEVEDIEF"
     gene            complement(3611..4762)
                     /locus_tag="KRO40_003446"
     CDS             complement(3611..4762)
                     /locus_tag="KRO40_003446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HBH2094240.1"
                     /translation="MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEK
                     AIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRGITSLNKKRKNHIISTNIEHPSV
                     LNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
                     VGKYLKGLKEKIYFHVDAIQSYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKEN
                     NRLKPMLTGGGQEIGIRSGTENVPGIYGLGEAVRILNKDLDAVISKVNNLKNILKNEI
                     IDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVSTGSACSSKKKGSYV
                     LNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK"
BASE COUNT         1549 a          937 c          471 g         2004 t
ORIGIN      
        1 attgaaaatt tagatatttt tctaaaaatt atctatgtta atagttaaat ttatgaacat
       61 tttttgtttt tatgttagga tatttcttag aaatgaaata cttcttaatt tgatttgata
      121 tgtatatttt tatagctatt ttattataaa aaaaaagaac ccttttataa ctaagggtta
      181 ctttttttct ctattttttc ttattatatc actatttttt ccctatttca atattttgac
      241 attttttcca ttatactgaa aagatatctt aaatttttaa cttggataaa ttttaaatca
      301 tatacttaaa attaacatac ttgttttcta ttttattaca cttaatcctt atttttatca
      361 ttctacaaaa caaaaataaa aaagaataag ataataaata aaatacttat caccttattc
      421 tttatttaat tattttacaa cgaaaaatct aaactacttt ttaaatagct tcctcttcca
      481 tcaatttatt tgtatattac tggtttaatt cttcaagtaa ctgattggtt cttgcaatac
      541 tttatcctaa actctggaaa ctttgtaaac tacctctcta gcatttggta aatttccatc
      601 tggaatacct acagcaatac caaatggtac agaataccct tctggtatat caagtagttc
      661 tctgtatttt ttatttgtat caaacttcat ctttattgac tctgattctt ttacatcttc
      721 tttatccaat acactcacaa gaccttcaat atccccttgt tcaacaggtg taaataaacc
      781 tctaaccatt cctattatac aacttccaag ccctagtgct tgtgcagctg ttgttatatt
      841 ccctgtaagt attcctatat catatggagc ccatgaacta ctttcatcat aagaaataaa
      901 taaaacggtt ggagcaccat aaaataactt aaagttttta tttatctcaa cattactcac
      961 ctcatgaatc ctagataaag tatcatcact aatctctttt aaaagtttct ggtcttgcac
     1021 aacagttatg tgccaaggct gtttattaca tcctgaaggt gctgcaaatg cacagtgtaa
     1081 taatgtgttt acttgctcat cactaatttg ttctgtcgta aattttcgta tacttctacg
     1141 actttgtatt aaatttattg tttggttgtc ttgaaaatta ttattcatat ctattcccct
     1201 ttttatgtat ttcttagtac aaatactaaa tcttcagaaa attaatctta taattaaatt
     1261 tctttacaat attattataa ttatttttag cttgtatgtg aagacttaaa aatataaaca
     1321 cttttaatat atctcaatta tatatataaa tgaaaatctg gtattcgtca tctatagaaa
     1381 ctgctctttt ctatagttta atcaatacca gattaataaa acatgatata ttaatttaaa
     1441 ggaccccatc cctctttaga atgaatctct gtttttacag acttaacact atctgtgtca
     1501 acatcccatg acctacctgc aacagaaata ccatttttac ctttatacca tctaccttca
     1561 tcataatcgt aaactaggga agtataccaa ttacccccag tcttattatt tgcaaataca
     1621 actacagtag catcagattt agtaggacta tatgcatatg gttgtatata tagtgtatcc
     1681 ttacttaatc catattttgc cttaaattca tctggaattg taggccaccc atttttatat
     1741 ttattgtcta ataaatattt tctaaaatca tcattaccct ttgaagctcc tggtattata
     1801 gaagggtctt gtgcaaatga tgcaatcaaa tctttcatac tttgatgtat atccctagcc
     1861 atttcaacac cgtctggatg ttttgtacaa gtaacataca cttttgcaat gctttctatt
     1921 ccagttattc catcataacc atcatcaaac gttgctgaat atattccacc tgacttacac
     1981 tttggttctg tttcaaagta cttaccatct ttgttttcta atacctcttt catgacttca
     2041 ttcttgcctt tacttgattc ctcagccatt gcaataacaa tttgagtctt tatattttct
     2101 ctattagaaa gacatgtaac tgctttactt ttttctatat ttctaaacaa tgctggaaca
     2161 gctactataa ctaaaatgcc tattatagat ataactacta acaattcaat tagtgtaaaa
     2221 ccctttttat tcataataat cattcccatt aaataaaatt atagtactta tttttaaata
     2281 ctacatatta ataaattgtc tacataaatc ctttcaacag aactactaat atacttacag
     2341 aactactaat atactcaata ttcaatttag taattaaata acttgtatgc taaaactcaa
     2401 tatcctctac ctctattttg tcaatagcat cctgtactaa tttttcaatg tcaagtgctg
     2461 tttcagattt ttctattttc tctaatctag gtttagtgac gggctttcta ggagaaaata
     2521 cactacaaca atcttcttca ggcaatatag atgtttcaaa agtccctatt tttttggcta
     2581 tatcaactat atctgattta tccattgcta taagtggtct aaacactggt aagtctacaa
     2641 cggcattagt acaagtaagt ccttgtatag tttgagatgc aacctgccca atactttcac
     2701 ctgtaattaa agcatcacaa tgtctttttt cagaaagtct ctgtgctatc ctcatcataa
     2761 atcttcttga aagaatagta gcttcttctt cattacaatt ctcgccaatt gctttttgta
     2821 tttctaagat attaacttta tgaagcctta ctctaccaca gtattttgcc agtattttag
     2881 ctaaatcctt aactttttcc tgtgaccttt cacttgtaaa tggataacta tgaaagtgaa
     2941 ctgcctctac ttccatacct ctttttgcaa ccatccatgt agctactggg ctatctatac
     3001 ctcctgataa aagagacata gctctaccat tcgttccaag tggcaatcca ccatatccag
     3061 gtatagtatc actatagacc atagtatgaa attctctgta ttcgcacttt attttaactt
     3121 ctggatttct tacatcaaca ttaatcctat ctcctacctt tgataataag tatccaccta
     3181 tatccatact catttcttga gaagtcaacc cgaaagactt atctcctctt cttgactcta
     3241 ccttaaaagt tttatatcca gcctctattt tttcttctaa catttttaaa gctatttctt
     3301 ttaatgtatc ataatctttt ttagctctta ctccagggca cacacccact atcccaaata
     3361 cttttctaac ttcttcaatt acttcttcat aatcatagtc ttctaaatca acatatattc
     3421 ttccatactc tttatataca ttaaatcttc caattggttt taacatattt cttatatttc
     3481 ttataagcct attctcaaat atatatctat tctttccttt tactccaatt tctccatact
     3541 ttactattaa tatattatac accatttcac ctcttaaact aatttattat cactatctat
     3601 acagtattct ttattttctt ttcattattg accttaagtc acaaattgat tctttcaaaa
     3661 ctttcacagc ttctaacatt tcttcttctg tattcatatc agataaacta aatcttattg
     3721 ttccatttat ttcttcattt gtaagaccta tagcatttaa tacgtaacta cctttctttt
     3781 tagaagaaca tgcagagcca gttgatacat aaataccttt ttgctctaag taatgaagta
     3841 aaacttctcc ttttgtccct ctaaatgata catttaatat atgacatact ccatcttctg
     3901 gagaattaat ttttatatct tctatattat caattatttc attttttaat atatttttta
     3961 agttatttac tttcgaaata acagcatcta aatctttgtt tagtattcta acagcttctc
     4021 caagaccata tattccaggt acattttctg ttcccgacct aattccaatt tcctgaccac
     4081 cacctgttaa cataggctta aggcgattat tttcttttat atacataaat ccaattccct
     4141 ttggaccatg aaatttatgt gcacttacac tcataaaatc tatattgtat ttagatggtc
     4201 taaagttaat ttttccatat gactgaatag catcaacatg gaaataaatt ttttctttta
     4261 aacccttcaa atactttcca acttcaccta ttggctgtat agttcctatt tcattgttaa
     4321 catgcatcat gcttactaag catgtagttg actttatcgc attttttaaa tcctctatat
     4381 ttattttccc atcttttccg acctctaaat aagttacttc aaaaccatct tcttctaaat
     4441 cttttaatgt atttaaaaca gaaggatgtt ctatgttagt agatattatg tgattttttc
     4501 tttttttatt taaactagta atacctctta ttatagtatt attacactct gtaccacctg
     4561 atgtaaaata aatctccttt tctttcgctc ctagagattt agctatatct tgtcttactt
     4621 cttttatagc tttttcaact tctacacctt ttctatggac agaagaagga tttccatatt
     4681 ccgtattaag tgcataaacc attttatcta taacttcttg ataaggtttt gtagttgcgc
     4741 tattgtctaa gtatatttcc aacttaatta cacctacctt tatttaaaat cttcaactct
     4801 aactattata ccactaatta tagtattttt tttgttaatc tttattaaaa agacaatctt
     4861 aaattataaa atattatttc atgaaaagct agttttttca ctttattaca aatttttata
     4921 gtaaaatata atatacttat actataccct acaaaaatat a
//
LOCUS       DAEQCW010000177         4587 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.178, whole genome shotgun sequence.
ACCESSION   DAEQCW010000177 DAEQCW010000000
VERSION     DAEQCW010000177.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4587)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.178"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(76..1071)
                     /locus_tag="KRO40_003447"
     CDS             complement(76..1071)
                     /locus_tag="KRO40_003447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBH2094241.1"
                     /translation="MRNLGNTNMKIKRVGFGGIPIQRITQDDTNLVINELEKQGINFI
                     DSARGYTISEEAIGIAIEGKRDKFFLATKSMSRDYDSMKRDVEISLNNFKTDFIDLYQ
                     FHNVKEEEYDNLFKDKMAYSALLEAKEQGKIKHIGITSHNLNTIEKAIEDGKFDTIQF
                     PYNIVEGQADEVFKKAHEKGIGIIVMKPLAGGALDNATLAIKYILSKEYIDVVIPGME
                     SVEQVRQNVAVLENLVLDEKDNKEIEEIRNSLGKKFCRRCEYCMPCAVGINIPLSFLC
                     EGYYTRYGLKEWAKEKYEVMDVKPTECIDCGLCESRCPYELPIREMLKTVVEKLG"
     gene            complement(1355..2191)
                     /locus_tag="KRO40_003448"
     CDS             complement(1355..2191)
                     /locus_tag="KRO40_003448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribonuclease IV"
                     /protein_id="HBH2094242.1"
                     /translation="MIKLGTHLSIAKGFANAAETAVYIGANTFQFFSRNPRGGNAKEF
                     DEKDIIKFQEIRKENNFAPLLAHAPYTMNLGGTKDDVYEFATRVIDEDIRRMDSLGIE
                     YMCFHPGSHVGGGVDFGIDRIVKGLNNAIKGDENITILLETMSGKGTEIGFKFEQLKS
                     IIDKIEHKEKIGVCLDTCHIFSAGYDIVNDLDGVLEEFDKVIGIERLKTVHLNDSMMP
                     FGDKKDRHAPIGEGKIGLKALIDFMEHPSLKHLPFFLETPFDDEGHKRELKMIKEILS
                     SK"
     gene            complement(2679..3242)
                     /locus_tag="KRO40_003449"
     CDS             complement(2679..3242)
                     /locus_tag="KRO40_003449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094243.1"
                     /translation="MKEVLVLRDLECIKAIAHPRRIDILKAFDKSPLSAKQLSQLLEE
                     PHAKINYHIKMLYKVGILELVEEKIKSGIVEKYYYPSAKNVVIGNRILNFSLDNGEEK
                     EELYISKFENMSEVFYKAAEEDVLENENIVDYHDISLTHDELVELSDTMKSKIDEILN
                     KRQHNVEGSKYDIAMVIVPTLEEECPS"
     gene            complement(3340..4269)
                     /gene="glsA"
                     /locus_tag="KRO40_003450"
     CDS             complement(3340..4269)
                     /gene="glsA"
                     /locus_tag="KRO40_003450"
                     /EC_number="3.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaminase A"
                     /protein_id="HBH2094244.1"
                     /translation="MNTLDETLLKEIISSNKKYTNYGQVASYIPELKNARRNDLGICI
                     IDSENNLYSAGNCSTKFTIQSISKPIVLAMALMDNDWEDVFSNVGMEPSGDPFNSIMK
                     LEINDTKKPCNPMINAGAIVTTSLINGSCLEEKEERMLSFFRKLAKNDNIGINYDVYK
                     SEKMTGDRNRAMAYLLKSDGFIRGNVEDVLDLYFKQCSIEIDSVDLARIGINLANYGV
                     DIENGEHLMSEMVSRIVKTFMMTCGMYDASGEFAIKVGIPAKSGVGGGIMASVPGRMG
                     IGVYGPALDKKGNSVAGVKVLEELSNKLKLNIF"
BASE COUNT         1472 a          889 c          434 g         1792 t
ORIGIN      
        1 atatttgtat ataagaccac atctaataaa aagaaatcgg agtaaattta atacaccgat
       61 ttcaataaat aaaatctatc ctagcttttc aacaacagtc ttaagcattt ctcttatagg
      121 aagttcatat ggacatctac tctcgcaaag cccacagtca atacactcag taggtttaac
      181 atccataacc tcatattttt ctttagccca ctcttttaat ccatatctag tataataacc
      241 ttcacataaa aaactcaatg gtatatttat tcctacagca caaggcatac aatattcgca
      301 tcttctacag aattttttac ctaaagaatt tcttatttct tcaatttcct tattatcttt
      361 ttcatctagc acaagatttt caagtacagc gacattttgt ctaacctgtt caacactctc
      421 catacctggt ataactacat ctatgtactc tttagatagt atatatttaa tagccagtgt
      481 tgcattgtct aaagcacctc cagctaaagg tttcattact attatcccaa ttcctttttc
      541 atgagctttt ttaaacactt catctgcttg tccttcaact atattgtaag ggaattgtat
      601 agtgtcaaat tttccatctt ctatagcttt ttctatagta tttaaattgt gactagttat
      661 accaatatgt tttatcttac cttgctcctt tgcctctaaa agggcactat aagccatttt
      721 atctttaaaa agattatcat actcctcttc tttaacatta tggaattgat ataaatctat
      781 aaaatcagtt ttaaaattat ttaaacttat ttcaacatct ctcttcattg aatcataatc
      841 tctggacata cttttagtag ctaagaaaaa tttatctctt tttccttcaa tggcaattcc
      901 gattgcttcc tcacttattg tataccctct tgcactgtca ataaagttta ttccttgttt
      961 ttctaactca tttataacta agttagtatc atcttgagta atcctttgta ttggaatgcc
     1021 cccaaagcca actctcttta ttttcatgtt agtattgcct aaatttctca tatctttccc
     1081 cacctaactt ttaataattt tttatataat ataaatatgt catctttaat tatacaacaa
     1141 attatgagaa tctttgcaat atatttacat actattcata atataattat attttatatc
     1201 agtctattca taatataatc atactttata cccagttaat ttgtatacaa tttttgttat
     1261 tcctatccat taatttaaat tatcacattt catgattata tctccaccct aattatgttg
     1321 agggcggagt atttcacata tttttaataa aggtttattt actagatagt atttctttta
     1381 tcattttaag ctctctcttg tgaccttcat catcaaaagg agtttctaag aaaaatggta
     1441 aatgttttag actaggatgt tccataaaat caattaatgc ttttaatcct atctttcctt
     1501 ctcctatagg agcatgtctg tcttttttgt ctccaaatgg catcatacta tcatttagat
     1561 ggacagtttt caatctttct atgcctataa ccttatcaaa ttcttccaaa accccatcta
     1621 aatcattcac tatatcataa ccagctgaaa aaatatgaca tgtatcaaga cacacaccta
     1681 ttttttcttt atgctcaatt ttgtctatta tactttttaa ttgctcaaat ttaaaaccta
     1741 tttcagttcc ctttcccgac atagtttcaa gaagtatagt tatattttca tcacccttta
     1801 tggcattgtt caatcctttt actattctat ctataccaaa atctacacca ccacctacat
     1861 gacttccagg atgaaaacac atgtattcaa ttcctaatga gtccatcctt cttatatcct
     1921 catctatcac ccttgttgca aattcgtata catcatcctt tgtaccaccc agattcatag
     1981 tatatggtgc atgtgcaagc agtggtgcaa aattattttc ttttctaatt tcttgaaatt
     2041 taattatatc tttttcatca aattctttag catttcctcc tcttggattt ctactaaaaa
     2101 attgaaatgt atttgcacca atatatacag ctgtctcagc cgcattagca aatccttttg
     2161 ctattgaaag atgtgttcct aatttaatca tattaatctc cttttatttg tactacgact
     2221 tgtactcaat tttaattttg aactactcca ccttaactac atttagccaa catatgaaga
     2281 tggagattcc tatttgatag tactttttca ctaaaaattc ataagctcta agggatgttc
     2341 tatcccaact aatctcattc ctcttttaac atatttctag cattgattta atttatatta
     2401 atttttaatt ttaatattta cactttaatt atacccattt taatcaattt caaatattat
     2461 aatcttacat actttgtata ttatctaagc acttcttaga tagtgtatac atcttacact
     2521 atacacatta tttacaaata caataggtat aagaaaacaa aaaaatagag attaaaaatc
     2581 attgttttac ccataccaaa aactattttt tgattattaa gtaaattttg atgttcaatc
     2641 tctaatatta tatctttaat taatccataa ttaattttct aactaggaca ttcctcctca
     2701 agagtaggaa ctataaccat agctatatca tacttagaac cttcaacatt gtgttgtctt
     2761 ttatttaaaa tttcatctat ctttgacttc atagtgtcac taagttcaac taattcatca
     2821 tgagtaagag aaatatcatg ataatcaact atattttcat tttctaaaac atcttcctct
     2881 gctgccttat aaaaaacttc actcatattt tcaaattttg atatgtacaa ttcttctttt
     2941 tcttccccat tgtctaaaga aaaattaagt atcctattcc ctataaccac attttttgca
     3001 cttggataat agtacttttc cacaatcccc gactttattt tttcctcaac taattctaaa
     3061 ataccaactt tgtataacat ttttatatgg tagtttattt ttgcatgagg ttcttccaat
     3121 aattgagata attgttttgc tgacaatggc gatttgtcaa atgcttttag aatatctatt
     3181 ctacgtggat gcgcaatagc ctttatgcac tccaaatctc gtaataccaa tacctctttc
     3241 attgacccct cctaaaaaat ttatttaatt catatttctt tacaatttaa ttatatatta
     3301 aattatatgt tgttgtcaaa aaaatccttt cttaatattt taaaaaatat ttaatttgag
     3361 tttatttgac aactcctcta aaactttaac tcctgcgacg ctgttacctt ttttgtcaag
     3421 cgcaggtcca taaacaccaa tccccatgcg tcccggcaca gaagccatta taccaccccc
     3481 aactccagat tttgcaggaa tgccaacttt aatagcaaat tccccagaag catcatacat
     3541 tccacaagtc atcataaatg tcttgacaat cctagaaacc atttcactca ttaaatgctc
     3601 accattttct atatctactc cataatttgc aagatttatt ccaattctcg ctaaatctac
     3661 agaatctatc tcaattgagc attgtttaaa ataaaggtct agaacatctt ctacattccc
     3721 tctgataaat ccatcacttt tcaataagta agccatagct ctgtttctat ctccagtcat
     3781 tttttcagac ttatagacat catagtttat tcctatatta tcattttttg ctaactttct
     3841 aaagaaacta agcattcttt cttctttttc ttctaaacaa ctcccattta taagggaagt
     3901 ggttactata gcccctgcat ttatcattgg attacagggt ttttttgtgt cattaatttc
     3961 aagtttcatt attgaattaa atgggtcccc acttggctcc attccaacgt ttgaaaaaac
     4021 gtcttcccaa tcattatcca taagtgccat agcaagcaca attggttttg aaatactttg
     4081 tatagtaaac tttgtgctac agtttccagc actataaaga ttattttcgc tatctatgat
     4141 acaaattcct aaatcatttc ttctagcgtt ttttaattct ggtatgtaac tagcgacttg
     4201 tccataatta gtatacttct tattagaact tataatttct tttaataatg tctcatctaa
     4261 cgtattcata tgcacctctt atattatgtt atatattcta ttttagcaca agtttatact
     4321 ataataaaac aatgttaaaa aaaattatac tttaaaatta ttttctacaa gaatcaattc
     4381 atttttcaaa caatttaaat agtttaaaga gcttaataat ttagtaattc aataatttaa
     4441 caacctagca atttagtaat ctaataatcc agtaatttaa caacctaata atttagcaat
     4501 ctaataattc aataatttaa caacctagta atctaactat ctaataatcc agtaacttaa
     4561 caacctagta atttagtaat tcaacaa
//
LOCUS       DAEQCW010000178         4579 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.179, whole genome shotgun sequence.
ACCESSION   DAEQCW010000178 DAEQCW010000000
VERSION     DAEQCW010000178.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4579)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4579)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4579
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.179"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            87..2498
                     /locus_tag="KRO40_003451"
     CDS             87..2498
                     /locus_tag="KRO40_003451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding cysteine protease Cwp84"
                     /protein_id="HBH2094245.1"
                     /translation="MRKYKSKNLSKLLALLTVCFLIVSTIPVSAENHKTLDGVETAEY
                     SESYLQYLEDVKNGDTAKYNGVIPFPHEMEGTTLRNKGRSSLPSAYKSSVAYNPMNLG
                     LTTPAKNQGSLNTCWSFSGMSTLEAYLKLKGYGTYDLSEEHLRWWATGGKYGWNLDDM
                     SGSSNVTAIGYLTAWAGPKLEKDIPYNLKSEAQGATKPSNMDTAPTQFNVTDVVRLNK
                     DKETVKNAIMQYGSVTSGYAHYSTYFNKDETAYNCTNKRAPLNHAVAIVGWDDNYSKD
                     NFASDVKPESNGAWLVKSSWGEFNSMKGFFWISYEDKTLLTDTDNYAMKSVSKPDSDK
                     KMYQLEYAGLSKIMSNKVTAANVFDFSRDSEKLDSVMFETDSVGAKYEVYYAPVVNGV
                     PQNNSMTKLASGTVSYSGYINVPTNSYSLPKGKGAIVVVIDNTANPNREKSTLAYETN
                     IDAYYLYEAKANLGESYILQNNKFEDINTYSEFSPCNFVIKAITKTSSGQATSGESLT
                     GADRYETAVKVSQKGWTSSQNAVLVNGDAIVDALTATPFTAAIDSPILLTGKDNLDSK
                     TKAELQRLGTKKVYLIGGENSLSKNVQTQLSNMGISVERISGSDRYKTSISLAQKLNS
                     IKSVSQVAVANGVNGLADAISVGAAAADNNMPIILTNEKSELQGADEFLNSSKITKSY
                     IIGGTATLSSNLESKLSNPTRLAGSNRNETNAKIIDKFYPSSDLKYAFVVKDGSKSQG
                     DLIDGLAVGALGAKTDSPVVLVGNKLDESQKNVLKSKKIETPIRVGGNGNENAFNELN
                     TLLGK"
     gene            2795..4372
                     /locus_tag="KRO40_003452"
     CDS             2795..4372
                     /locus_tag="KRO40_003452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp5"
                     /protein_id="HBH2094246.1"
                     /translation="MKAPKTILTILTIALTLSSISIIPSYALTEEKLIGNGRYETAVK
                     ISQKAYSSSPNVVLVNDNSLADALSATPFAKAKGAPILLTESDKLDDRTEKEIKRLGA
                     KDIYLIGGTAVLNKDIENKLKSNGLNVERINGKDRYETSLILANKLKDIKDIKEVAVV
                     NGEKGLSDAVSVGAPAAQNKMPIILSSPKDGVEAFDKFIRDEKVIKAYVIGGTNSVSR
                     AVEKSLPNAERVSGKDRNETNAKVIEKFYTDTNLSNLYVTKDGSKNENQLIDSLAVGV
                     LAAKNESPVVLVGNKLNTKQRDILSTKKLNTITQVGGNGNEEAFDEIKSLQEKTVFEA
                     KTVEELTDMINIASPNDIINFKPKENTVNEAFRMVTNKPITVNIKGDCSKTLTVDMPN
                     GEVNNYATLVNVIVRNIGEGGFNNHDTITILSVRDKNGRVIENTRNSDIDTLMILASA
                     NDTKLINDGYIGKLIDNSSNSDITNNGTIDKKVNQVEDLEAKVDSIEKAIDSISQKVN
                     KIQDILDKLGFLKKFLS"
BASE COUNT         1843 a          543 c          849 g         1344 t
ORIGIN      
        1 cataatccat attttatcaa aataaaatat gaccttaatt tagaaatctg atataataaa
       61 aattaaatac atataagggg gtaaacatga gaaagtacaa atcaaaaaac ttgtcaaagc
      121 tactagcatt gttgacagtt tgctttttaa tagtgtcaac aatacctgtc tcagcagaaa
      181 accataaaac tctagatgga gtagaaactg cagagtattc tgaaagctat cttcaatacc
      241 tagaagatgt caaaaatgga gacacagcaa aatataatgg agtaatacct tttccacatg
      301 aaatggaagg tacaacactt cgaaataagg gtagaagtag tcttccatca gcatataaat
      361 caagtgtagc atacaaccca atgaatcttg gtcttactac accagcaaaa aatcaaggaa
      421 gtcttaatac atgctggtct ttttcaggta tgtcaacgtt agaagcatat cttaaattaa
      481 aaggatatgg aacgtatgac ttatcagaag aacatttaag atggtgggca actggtggaa
      541 aatatggatg gaacttagat gatatgtcag ggagttcaaa tgtaacagct ataggatatc
      601 tgacagcatg ggcaggtcct aagttagaaa aggacatacc atataatctt aaatctgagg
      661 cacaaggtgc aactaaacct tcaaatatgg atactgcacc tactcaattt aatgtaacag
      721 atgttgttcg tcttaataaa gataaggaaa ctgtaaagaa tgctataatg caatatggtt
      781 cagtgacatc aggttatgca cattattcaa catattttaa taaagatgaa acagcatata
      841 actgtacaaa taagagagct ccattaaatc acgctgtagc gatagtagga tgggatgata
      901 attattcaaa agataatttt gcatctgatg taaaaccaga atcaaatgga gcatggttag
      961 taaaaagtag ttggggagag tttaattcta tgaaaggatt cttctggatt tcttatgaag
     1021 ataaaactct actaacagat acagataact atgcaatgaa atcagtatca aaaccagata
     1081 gtgataaaaa aatgtaccaa cttgaatatg ctggtcttag caagataatg tcaaataaag
     1141 taacagcagc aaatgtattt gattttagca gagactctga aaaacttgat tctgttatgt
     1201 ttgaaacaga ctctgtagga gcaaaatatg aagtatatta tgcaccagtg gtaaatggag
     1261 ttcctcaaaa caattcaatg acaaaacttg caagtggaac agtatcatat tctggataca
     1321 taaatgtacc tactaattct tacagcttac caaaaggtaa aggagcaata gtagtagtta
     1381 tagacaacac agcaaatcct aatagagaaa aatcaacttt agcatatgaa actaatatag
     1441 atgcatatta tttatatgag gctaaagcaa acttaggtga aagctacata cttcaaaaca
     1501 ataagtttga ggatataaat acatatagtg aattttctcc ttgtaacttt gttataaaag
     1561 ctataacaaa aacatcttct ggacaagcta cttcaggaga atctttaact ggagcagata
     1621 gatatgaaac agcagttaaa gttagtcaaa aaggatggac ttcttcacaa aatgcagtat
     1681 tagtaaatgg agatgcaata gtggatgctt taacagctac accatttaca gcagcaattg
     1741 actctccaat tcttttgaca ggaaaagata acttagattc aaaaactaag gcagagttac
     1801 aaagattagg aactaaaaaa gtttatctaa taggtggaga aaattcttta agcaagaatg
     1861 tacaaactca acttagtaat atgggtatat cagtagaaag aatttcaggt agtgatagat
     1921 acaagaccag tatatctcta gctcaaaagt taaatagtat aaaatctgtt tcacaagttg
     1981 cagtggcaaa tggtgtaaat ggacttgcag atgcaataag tgttggtgca gcagctgctg
     2041 ataacaatat gccaataata cttactaatg aaaaaagtga gttgcaaggt gctgatgagt
     2101 ttttaaattc atctaaaata actaagtctt atataattgg tggaacagct actttatcat
     2161 caaatttaga aagtaagctt tcaaatccaa caagacttgc aggcagtaat agaaatgaaa
     2221 ctaatgctaa gataatagat aaattctacc ctagctcaga tttgaaatat gcttttgttg
     2281 ttaaagatgg ttcaaagagt caaggagact tgatagatgg actagcagta ggagcattgg
     2341 gtgctaaaac tgattcacca gtagttctag ttggaaataa gttagatgaa agtcaaaaaa
     2401 atgtacttaa gtctaagaaa atagaaactc ctattagagt tggtggaaat ggaaatgaaa
     2461 atgcttttaa tgaactaaat actcttttag gaaaatagtg aatggaaaga tagtaaggat
     2521 atacatttta ttattaaaaa atgttcaata gaagtttata aatataaaat aacaaaaagg
     2581 ggtgtctcaa aatgaacttt ttagttcatg aggcactctt ttttgttgtt ttatattttt
     2641 atcatttaaa taatgaaaaa taggattgtc tatattttta gatagttttc ttattattga
     2701 tgaaaaatgt aataatttta aactgtaaaa tagtgtaaag ttattttata atataaatat
     2761 agtaagattt taaacaaaat aagggggaat aataatgaaa gcaccaaaaa ctattttaac
     2821 aatactgaca atagcgctta ctttaagtag catttctata ataccatcat atgcacttac
     2881 agaggaaaaa ttaataggta atggtagata tgaaactgct gtaaagataa gtcaaaaggc
     2941 atacagttct agtcctaatg tagtgctagt taatgacaat tcattagctg atgcactttc
     3001 agctacacca tttgcaaagg ctaaaggagc accaatactt ttgacagaaa gtgataagct
     3061 agatgatagg actgaaaaag agataaaacg tctaggagct aaagatattt atttgatagg
     3121 aggtactgct gtacttaata aagatataga gaacaagtta aaaagtaatg gacttaatgt
     3181 agaaagaatt aatggtaagg atagatatga aacttcactg attttggcta ataagcttaa
     3241 ggatataaaa gatattaagg aagttgctgt agtaaatggt gaaaaaggat tgagtgatgc
     3301 tgttagcgtt ggggcaccag cagctcaaaa taagatgcct ataattttgt ctagtcctaa
     3361 ggatggagta gaagcatttg ataaatttat aagggatgag aaagttataa aagcatatgt
     3421 aattggaggt acaaattctg tttcaagagc tgtagaaaag agtcttccta atgcagaaag
     3481 agtgagtggg aaagatagaa atgagactaa tgctaaagtt atagaaaagt tttacactga
     3541 tacaaattta agtaatttat atgtaactaa ggatggtagt aaaaatgaga atcaactaat
     3601 agactcgtta gctgttggcg tattggctgc aaaaaatgag tctcctgttg ttttggttgg
     3661 taataaatta aacacaaaac aaagagatat acttagtact aaaaaattaa atactataac
     3721 acaggtaggt ggaaatggaa atgaagaagc ttttgatgaa attaaaagtc tacaagaaaa
     3781 aactgtgttt gaagcaaaaa ctgttgagga attaactgat atgataaata tagcaagtcc
     3841 taatgatatt ataaacttta aaccaaaaga gaatactgta aatgaagctt ttagaatggt
     3901 aacaaataaa ccaataactg tgaatataaa gggtgattgt tcaaagactc ttacagtaga
     3961 tatgcctaat ggtgaagtga ataactatgc tactttggta aatgttatag ttagaaatat
     4021 tggagaaggt ggatttaata atcatgatac aatcactata ttgtcagttc gtgacaaaaa
     4081 tggtagagtt atagaaaata ctagaaattc agatatagat acgttgatga tattagcttc
     4141 tgctaatgat acaaaattga ttaatgatgg atatatagga aaacttatag ataattcatc
     4201 taatagtgat ataactaata atggtactat agataaaaaa gttaatcagg ttgaagattt
     4261 agaggctaaa gtagattcaa ttgaaaaagc tatagattct ataagtcaaa aagtcaataa
     4321 aatacaagat atactagata agcttggatt tctaaagaaa tttcttagct aagaatatgt
     4381 atatttaagt gaagtgtgtg ttgtaattgt tctaaagtta tgtagttaaa caggtttata
     4441 tacaaataga tttatagata aatatgtagt ttagtatata tttgaataag ctttggggag
     4501 gtaacatggg gattggaatt gaatgtaaca aaaaaataaa taaaagtatt gacaaaacta
     4561 gaataaagaa aaataatct
//
LOCUS       DAEQCW010000179         4483 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.180, whole genome shotgun sequence.
ACCESSION   DAEQCW010000179 DAEQCW010000000
VERSION     DAEQCW010000179.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4483)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.180"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            191..1330
                     /locus_tag="KRO40_003453"
     CDS             191..1330
                     /locus_tag="KRO40_003453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBH2094247.1"
                     /translation="MVIKLTIEEYKNKYFTGNKIVLSLNSFDNKELYYHETENILNLI
                     NEIDKLTSSKIFKTIEDKNDLALESYYSSVIEGAFSTRKIAKSIIRGKMKPSNKSEYM
                     IYNNHRALEYGLDNLDKLYSHKFIYDLHHILGENCLDSEEYEYRTEKVYVCDSKGEII
                     HIGLEPLKIYDFMSKLIDFMENSKVSNLIKSAIIHFYFVYVHPFSDGNGRTSRALSYL
                     YLIDKGYDTFKEFSISYMISKNRTKYYKAILDVENKGNNLTVFIEFMLKSIIQSINEM
                     RNMHDRKSLESILKEELFENDITLSATEEHILKYICNKDNYSMTLENYIKKNKSRYLK
                     AGIKEIELVDQLMEVFSNLEEIEILSKEKNIYKVNDKYLKMLDID"
     gene            1356..1544
                     /locus_tag="KRO40_003454"
     CDS             1356..1544
                     /locus_tag="KRO40_003454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094248.1"
                     /translation="MNNKKKAFLISGAINVISLIIVFSLFHYNIIENSTQNMIITVIL
                     IFIFEMIKIKIIEKYYKL"
     gene            2328..4112
                     /locus_tag="KRO40_003455"
                     /pseudo
     CDS             2328..4112
                     /locus_tag="KRO40_003455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
BASE COUNT         1930 a          495 c          718 g         1340 t
ORIGIN      
        1 tattataaat aatagttgta aacttcctgt aacatatatt ttaaatgctt attcttaaat
       61 ttttgcatta tttattaaaa tttattatgc tttaacgcta aattgagttt gataattata
      121 aaacaaataa tcaaaaatag tgtaaaaatt aatacttttt gttaatatta atagataaag
      181 ataatctaag gtggtgatta aactgacaat agaagaatac aaaaacaaat actttactgg
      241 aaataaaatc gtactttctc taaatagttt tgataataaa gaactatact atcatgaaac
      301 tgaaaatata ttaaatttaa taaatgaaat agataaatta acatcaagta agatatttaa
      361 aacaatagaa gataaaaatg atttggcact agagtcttat tattctagtg taatagaagg
      421 tgctttttca actagaaaga ttgcaaaatc tataattaga ggaaagatga aacctagtaa
      481 taaaagtgaa tatatgattt acaataatca tagagcctta gaatatggat tagacaactt
      541 agataaatta tatagtcaca aatttatata tgatttgcat catatattgg gcgaaaactg
      601 cttggattca gaagaatatg agtatagaac tgaaaaagta tatgtatgtg attcaaaagg
      661 tgagattata catatagggc ttgaaccttt gaagatatat gactttatga gtaaattaat
      721 agattttatg gaaaatagca aagtaagtaa tttaattaaa agtgctataa ttcattttta
      781 ctttgtatat gttcatcctt ttagtgatgg taatggaaga acatcaagag ccttatcata
      841 tctatatttg attgataaag gatatgatac tttcaaggag ttttcaatat catatatgat
      901 atctaaaaac agaactaagt attataaggc tatacttgat gtagaaaaca aaggaaataa
      961 tttaactgta tttatagagt ttatgctcaa gtctataata caatctatta atgagatgcg
     1021 taatatgcat gatagaaaat ctttagaaag tatattaaaa gaagaattgt ttgaaaatga
     1081 cataactcta tcagcaacag aagaacatat attaaaatat atttgcaata aagataacta
     1141 ttctatgaca ttagaaaatt atataaaaaa gaataaaagt agatacttaa aggctggaat
     1201 aaaggaaatt gaattagttg accagttgat ggaagtgttt agtaatcttg aagagataga
     1261 gattttgtct aaagaaaaaa atatatataa agttaatgat aagtacttaa aaatgcttga
     1321 tatagactaa tttagataat ctggagaggg aatatatgaa taataagaaa aaggcatttt
     1381 tgatttctgg ggctataaac gtaatttcat taattattgt tttttcattg tttcattata
     1441 atattataga aaatagtaca caaaatatga taataactgt aatcttaatt tttatttttg
     1501 aaatgataaa aataaaaatc atagagaaat actataaact ataaacaaga aatatctttt
     1561 ctaagagcat attgtacaat atgctcttaa tttagttata tagatttaat ataaataatg
     1621 tattttttgt agatgattta tgtaagattt atgaccaatt tgtgtatgat ttatgttctt
     1681 taatcatgac aatattatat tgtaaaaaat aaatttaata aaaaatgact tggaatttat
     1741 attctaggtc ttttttatat aaaaatttaa taagtttcaa atgttggtaa ctttgacagt
     1801 agaaaacgtc tattgagata acgaggattc taatttaggg ggagatatat tagcacttaa
     1861 agtagtatat gcaacagata taatctttat aaaagtaatt ctaattaaaa tgtaaatata
     1921 aagaataatt aaaaaaatat cgcaattatt tgtttttcat atggataaaa ttggttattt
     1981 aatatataat tacaagtata aataataaaa tttatttgta aaaagagtag cacttttaat
     2041 tctaaaggct acttttttta tacaaaaccc tattttttat aacaattcat taacataaaa
     2101 atcaaactta ccttaaaata taaatttaca aatttttcaa tcaataagaa aatttcttta
     2161 ttccttacat aatgactgca atgtaacaaa ataattacaa attaattatg aaatcattat
     2221 agttagaaac ctctttaaaa ttagatatta agtatccttt agaattagaa cgggaacaaa
     2281 gttaaaaaat taagtaatat caaatggaca agggggaaga aaataaaatg aaaataccaa
     2341 agaagattgc tgcaatgctt acagttacaa tgatagctgg aagttcaaca gcaggcatag
     2401 ctagtgcaca aactgtggca acaaatttaa cagggcaaga aagatatgaa actgctgtta
     2461 aaataagtca agatggatgg aaaaatgctg atgaggtagt aatcgtaaac gactcatcta
     2521 tagcagatgc tctatctgca acaccatttg caaaagcaaa aaatgctcca atacttttaa
     2581 caagtaaaga taaattaaat gataagacga aagcagaaat acaaagatta aaagctaaaa
     2641 aagtatactt aataggtgga acttctgtat taagtacaaa tatagaaaaa gaaataaaaa
     2701 atttaaaaat atcttttgag agaatctctg gagctgagag atatcaaaca tccttagaat
     2761 tagcaaagaa attagatgct ataagtgatg ttaagaaaat agctgtagtt aatggtgaaa
     2821 aaggacttgc agatgctgta agtgtaggag caccagctgc acaaaacaat atgccagtaa
     2881 tacttgctga ttctaaaaat ggaacagcag ttgcagacaa atttataaaa gatgctggaa
     2941 taactcaatc ttatgtagta ggtggagaga gttcaatttc tgaagctgtt aaaaataaac
     3001 taccaaatag tacaagacta ggtggaacag atagaaatga tacaaatgca aaagtaataa
     3061 aagaatttta taaaaagaca gatttaaaaa atgcttatgt aactaaagat ggtatgaata
     3121 aacaagacca acttatagat gcactagcag taggtgtatt aggtgctaaa aatcaatcac
     3181 cagtagtttt agttggaaag aacttatcag cttcacaaaa atctctagtt aactctaaga
     3241 gttttgataa gataactaaa gttggtggga atggtaatga gacagcattt aatgaaatga
     3301 agtcattaca agaagtaaaa acagttgaag ctaaaacaat ttctgaatta aaatcagcta
     3361 tagataaagc tactgctaat gatgttataa actttaagcc aactagtgag gttaaagaag
     3421 catttacaat acaaactgat aaagcagtaa cagtaaactt aaatggtaca tatacaaaga
     3481 ctgtaactat caacatgcct aatggagatg taaataacta tgcaaaagtg gatgatttag
     3541 ttatagatga tgtaaaagat ggaacttttg ttaactatgg aaaaataact aacttaaagg
     3601 ttaatgataa aaatggagcc aagatagaaa ataattctaa aggtgagatt ggtagtttaa
     3661 cagtagcatc tggagcaagt caagtaaaag tgactaatgg tggtaagata actacagtta
     3721 caaataattc taaagggact actatagata ataaaggtac aataagtagt gttaagggag
     3781 ataattctcc aacaataagt ggaaatagtc caagttctaa ttcatcagga ggaagttcat
     3841 caagtggagg ttcttcacat ggaggaggct catcttcagg aggaagttct tctaatcaaa
     3901 catcagtaaa taatgaagca gcaaaaataa caagcgtgcc tacaccagca aaagatgcaa
     3961 ctagattaac tatgccatca gtatcaagtg gatatactat agcaataaaa acatcaagta
     4021 atgagagtgt tataaaaaaa gatggaacaa taatacctcc aaatacagca acaacagtaa
     4081 aattagtatt tacggtaaca catacatcaa gtggtaaaac agcagataca aaagaactat
     4141 ctgtaacagt accagctaaa tcaacagatg aagaattaca agcagcatta gacaatgaag
     4201 tggcaaaaat aacaagcgtt cctgcaccag caaaagatgc aactaaatta actatgccat
     4261 cagtatcaag tggatatact atagcaataa aaacatcaag caataagagt gttataaagg
     4321 aagatggaac aataatacct ccaaatacag aggaaacagt aacattggta tttacagtaa
     4381 cacaagaatc aagtggtaaa acagcagata caggagaaat agatgtagta gtaccagcca
     4441 aatcaacaga tggggaaata caagcagaag tacaagctga ggc
//
LOCUS       DAEQCW010000180         4473 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.181, whole genome shotgun sequence.
ACCESSION   DAEQCW010000180 DAEQCW010000000
VERSION     DAEQCW010000180.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4473)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4473)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4473
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.181"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     misc_binding    77..311
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            361..1380
                     /gene="pheS"
                     /locus_tag="KRO40_003456"
     CDS             361..1380
                     /gene="pheS"
                     /locus_tag="KRO40_003456"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HBH2094249.1"
                     /translation="MQEKLLALREAALAEIKEAQSIESVESLRVKYLGKKGEITAILK
                     EMGKLSAEERPVVGKVANEVRENIELSINSKKEEINAIEKERKLKEEVIDVTQPGKVL
                     KVGKKHPITQIIDEVTDIFIGMGFSIAEGPEVETVENNFDALNAPKDHPSRDMSDTFY
                     INDGVLLRTQTSPVQVRTMRSQELPIKVIAPGRCFRSDSPDATHSPMFHQIEGLVVGK
                     DVTMAEFKGTMDIFVEKLFGSDIKTKFRPHNFPFTEPSAEVDVTCFKCGGKGCPMCKY
                     EGWIEILGSGMVHPNVLRNCGIDPEVYSGFAFGVGVERLAMLKYEIDDIRLLFENDMR
                     FLNQF"
     gene            1397..3790
                     /locus_tag="KRO40_003457"
     CDS             1397..3790
                     /locus_tag="KRO40_003457"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HBH2094250.1"
                     /translation="MLVSLKWLRDYVDIDMDVKEFADKMTMSGTKVETIDYYGEEIEN
                     ILVGKILEIKQHPNADKLVVTKVDIGDKVVQIVTGATNISEGDYIPVAVNGSKLPGGV
                     EIKQTDFRGELSDGMMCSAAELGIDEHYIEEYKRGGIYILDHEDSYELGKDIKDVLGL
                     KDALIDFELTSNRPDCKCMMGIAREAAATIGTKVKYPEIEVKESDEEIDFKVEIDNPD
                     LCRRYVARMVTDVKIEPSPYWMQRRLTEAGVRPISNIVDITNFVMLELGQPLHAFDIN
                     QVETGRIVVRNAKDGEKLVTLDDVERTLDKDMLVITNGEKSLGLAGVMGGANSEITSN
                     TKTVLFESANFKPENIRMTAKKVGIRSEASSRNEKDLDPNLAEIAANRAAQLVEMLGA
                     GKVLKGVVDVYPNKPEPKKLVVNPQRINHLLGVDVPMEQFVGILESLEFKCNLVANDK
                     LEIDVPSFRTDMEQEADVWEEIARIYGFENIPSVQLEGNTTAGIKTSKQKFMDALKDN
                     STAVGLNEILTYSFVSPKGVDKIRVPEGNAKRNFVKLLNPLGEETSVMRTTLIPNMLD
                     VLSTNVSHKIEEVSAFECGHIFIPQDSELPKEENRMCVGMYGKDVDFFALKGTIETIL
                     VNVGFKGYEIEPQDNNTTFHPGRCAKIVYNNKYVGTLGELHPDVIENYNLGQRVYVAE
                     IDIDFVFDNSDRTKNYVPLPKYPSTSRDIALIVKDDVFVKQIEDIIKENGQGLVESYK
                     LFDVYKGSQIEAGYKSIAYSITYRSKDKTLTDEDVAKVHDKILSELSEKLNANLRSN"
     gene            3815..4405
                     /gene="zapA"
                     /locus_tag="KRO40_003458"
     CDS             3815..4405
                     /gene="zapA"
                     /locus_tag="KRO40_003458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HBH2094251.1"
                     /translation="MNKVMVKIHGAEYPMVGDKSEKFMISIADFVDKEMDKITRQNPK
                     LSLSVAAILTALNISDLLFECSDENEKLIKANEELSKKVGASNEELQLEIKSLKLTIA
                     EKEAENREAETKMKELIEIIENKKQEIFELSNTTEGSRAELDAYKNKIEELSTQLEEA
                     NERATIAENLASEFQNKAYDLQLKCTGLNNDAKNVE"
BASE COUNT         1760 a          520 c          920 g         1273 t
ORIGIN      
        1 gtattggata tatattaaaa atagtcacat aatttgaatg gaaatgatat aatactaaaa
       61 taaacaatat aatattgtaa atgcaatgaa agaggaaagt attttgatta aacttagtaa
      121 agagataaac acctaggctg ggagtgtttt ctaagaggtc atgagaagtt ccctctggag
      181 taacagagct gaaattttac agtaggcttt gacgtcaaaa acgcgttaag tttgttagag
      241 gtggtttgat gatttttaaa ttgttaaact actagggtgg taccgcgaaa ctatagcctt
      301 tcgtccctag acagggattg aggggctttt tttatacaaa aaaacgaaag ggtgatatgt
      361 gtgcaagaaa aattacttgc tttacgtgaa gcagctttgg ctgaaataaa agaagcacaa
      421 agcatagaaa gtgtagaaag tttaagagtt aagtacttag gaaaaaaagg tgagataact
      481 gccatactta aagaaatggg taaattatct gctgaagaaa gaccagtagt tggtaaggtt
      541 gccaatgagg taagagaaaa cattgaactt agcataaatt ctaaaaaaga agaaataaat
      601 gctattgaaa aagaaagaaa attaaaagag gaagtgatag atgttactca accaggaaaa
      661 gttttaaagg ttgggaagaa gcatccaata actcaaatta tagatgaagt aacagatata
      721 tttatcggaa tgggattctc tatagcagaa gggccagaag ttgagactgt tgaaaacaac
      781 tttgacgcat taaacgctcc taaagaccat ccatcaagag atatgagcga tacattctat
      841 atcaatgatg gggtattact tagaactcaa acatctccag ttcaagtaag aactatgaga
      901 agtcaagagt taccaataaa agtaattgca ccaggtagat gttttaggtc agactcgcca
      961 gatgctacac actcaccaat gttccatcag atagaagggc ttgttgttgg aaaagatgtt
     1021 actatggcag aatttaaagg aactatggat atcttcgttg aaaaattgtt tggttctgat
     1081 atcaaaacta agtttagacc tcacaacttc ccatttacag aaccaagtgc agaggttgat
     1141 gttacttgtt tcaaatgtgg tggtaaaggt tgcccaatgt gtaaatatga aggttggata
     1201 gaaatattag gttcaggtat ggttcatcca aatgtgctta gaaattgtgg aatagaccca
     1261 gaagtttaca gtggatttgc atttggagtt ggggttgaaa gacttgcaat gcttaaatat
     1321 gaaatagatg atattagatt attattcgaa aatgatatga gattcttaaa tcaattttaa
     1381 ttaggagggt atgtagatgt tagtatcttt aaaatggctt agagactatg ttgatataga
     1441 catggatgta aaagagttcg ctgataaaat gacaatgtca ggaactaaag ttgaaacaat
     1501 agattattat ggtgaagaaa tagaaaatat attggttgga aagattttag aaataaaaca
     1561 acatccaaat gctgataagt tggttgtaac caaagtagat attggagata aagttgttca
     1621 aatagttaca ggagctacaa atatatcaga aggagattat attccagtag ctgtaaatgg
     1681 ttctaagtta cctggaggag ttgaaatcaa acagactgat ttcagaggtg aattatcaga
     1741 tggtatgatg tgttcagcag ctgaactagg tatagatgaa cattacattg aggagtataa
     1801 aagaggtggt atatatattt tagaccacga agattcttat gaattaggaa aagatataaa
     1861 agatgtttta ggattaaaag atgctttaat agattttgaa ttaacttcaa acagacctga
     1921 ttgtaaatgc atgatgggta tagctagaga agcagctgca actataggaa caaaagtaaa
     1981 atatcctgaa atcgaagtaa aagaaagtga cgaagagata gatttcaaag ttgagataga
     2041 taatccagat ttatgtagaa gatatgttgc tagaatggtt acagatgtaa aaatagaacc
     2101 ttctccatat tggatgcaaa gaagacttac agaagcagga gtaagaccta taagtaacat
     2161 agtcgatata acaaacttcg taatgttaga gcttggtcaa ccacttcatg cttttgatat
     2221 aaatcaagta gagactggaa gaatagtagt aagaaatgct aaagatggag agaaacttgt
     2281 aacattagat gatgttgaga gaacattaga caaagatatg ctagttataa caaatggaga
     2341 aaaatcactt ggtttagctg gtgtaatggg tggtgctaac tcagaaataa cttctaatac
     2401 gaagactgta ctttttgaaa gtgccaattt caaaccagaa aacataagaa tgacagctaa
     2461 aaaagttggt attaggtcag aagcatcttc aagaaatgaa aaagacttag accctaatct
     2521 tgcagagata gcagcaaata gagctgcaca gcttgttgaa atgttaggag caggaaaagt
     2581 tttaaaaggt gttgtagatg tatatccaaa taaaccagaa cctaaaaaat tggtagtaaa
     2641 tcctcaaaga attaaccatc tattaggtgt agatgtacca atggagcagt ttgtaggaat
     2701 tttagaatca ttagagttta aatgtaattt ggtagctaat gataaattag aaatagatgt
     2761 accaagcttt agaacagata tggaacaaga agctgatgta tgggaagaaa tagctagaat
     2821 ttatggattt gagaatatac cttctgtaca attagaagga aatacgacag caggaattaa
     2881 aacttcaaaa caaaaattca tggatgcttt aaaagataat tcaactgctg taggattaaa
     2941 tgaaatatta acatattcat ttgtaagccc taagggagta gataagataa gagtaccaga
     3001 aggtaatgca aagagaaatt ttgttaaatt acttaaccca ttaggagaag aaacttctgt
     3061 aatgagaact actttaatac caaatatgtt agatgtttta tcaactaatg tatctcataa
     3121 aatagaagaa gtatctgcat ttgagtgtgg acatatattc atcccacaag attcagaatt
     3181 acctaaggaa gaaaatagaa tgtgtgtagg tatgtatggt aaagatgttg acttctttgc
     3241 actaaaagga actatagaaa ctatacttgt aaatgtcgga tttaaaggtt atgaaattga
     3301 acctcaagat aataatacta ccttccaccc tggtagatgt gctaaaatag tgtataataa
     3361 taaatatgta ggtacattag gtgaattgca tccagatgtt atagaaaact acaatctagg
     3421 tcaaagagtt tatgtcgctg aaatagatat tgactttgta tttgataatt ctgatagaac
     3481 aaagaattat gtgccattac caaaatatcc atctacatca agagatatag ctcttattgt
     3541 taaagatgat gtatttgtaa aacaaataga agatataata aaggaaaatg gtcaaggatt
     3601 agtagaaagc tacaagttat ttgatgttta caaaggttct caaatagaag ctggatacaa
     3661 gtcaattgca tattcaataa cttatagaag taaagataaa actctaacag atgaagatgt
     3721 agctaaggtg catgataaga tattaagtga attaagcgaa aaattaaatg ctaacttaag
     3781 atcaaattaa caactaatgt cgggggaggt taggatgaac aaagtaatgg ttaaaatcca
     3841 tggcgctgaa tatccaatgg ttggagacaa atcagagaag tttatgatta gtattgctga
     3901 ttttgtagac aaagaaatgg ataaaataac acgtcaaaac ccgaaattga gcttatcagt
     3961 tgctgcgata ttaactgcat taaatatatc agacctttta tttgaatgtt cagatgagaa
     4021 tgagaagttg attaaagcta atgaagaatt gagtaagaag gttggagcat ctaatgaaga
     4081 gcttcaatta gaaatcaagt ctttaaagct tacgatagca gaaaaagaag cagaaaatcg
     4141 tgaagctgaa actaagatga aagagttaat tgagattata gaaaataaaa agcaagaaat
     4201 attcgaactt agtaatacga cagaaggttc tagagcagag ttagatgctt ataaaaacaa
     4261 gattgaggag ttaagtactc aacttgaaga agcaaatgaa agagctacta tagctgaaaa
     4321 cttagcttct gagtttcaaa acaaagctta tgatttacag ttaaaatgta cagggttaaa
     4381 taatgatgca aaaaatgtgg aataaactaa aagatttgct gtctcttgtt ttttgagaca
     4441 gcttctttta atgtataaat ataaatgcta tat
//
LOCUS       DAEQCW010000181         4429 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.182, whole genome shotgun sequence.
ACCESSION   DAEQCW010000181 DAEQCW010000000
VERSION     DAEQCW010000181.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4429)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4429)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4429
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.182"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            116..1714
                     /locus_tag="KRO40_003459"
     CDS             116..1714
                     /locus_tag="KRO40_003459"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative manganese-dependent inorganic
                     diphosphatase"
                     /protein_id="HBH2094252.1"
                     /translation="MSLLVFGHKNPDTDSICSAISLAHLKNKLGIKATAYALGDIRKE
                     AKYALDYFKVDAPEILDNVRIQVRDLNYDKVVPLTPTSSILEAYNLMDEKNVKTLPVT
                     YDDGTFAGIITMKEIAKNLLHQHFTTIHTSLSNICKNLNGTILVDCGEDIKGRVVTLS
                     FGMETLIETLKEGDIAIVGDRYDSIEYAIDTKVKLLILTNHTEISKDLLALAKINGVS
                     VVSVESDNYKTSNVINQCSFLDSIEATENLITFKEDDYMDEIKEIMLETNFRSYPILD
                     DDNKFLGLVSKGHLLNPSKKNVVLVDHNEYAQSADGIEQANIVEIIDHHKLGGISTDV
                     PMSFRVMPVGCNSTIIYQMYKENNVEIPYEIAGLLLSAILSDTLLFKSPTTTDIDKKA
                     CEELSKIAKVDMEKYAMDMFKCGTSLDEYTIEEIVNMDFKEFNMSGHRVGIGQVFTLD
                     IDSIFAKKDEFLSYINSTDYDKLILAVTDIIKEGSYLIYKAEDSLIANAFGVEGVQGT
                     FAPGVVSRKKQLVPNLTTAIKNFK"
     gene            complement(1953..3998)
                     /gene="bclA1"
                     /locus_tag="KRO40_003460"
     CDS             complement(1953..3998)
                     /gene="bclA1"
                     /locus_tag="KRO40_003460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA1"
                     /protein_id="HBH2094253.1"
                     /translation="MRNIILYLNDDTFISKKYPDKNFSNLDYCLIGSKCSNSFVKEKL
                     ITFFKVRIPDILKDKSILKAELFIHIDSNKNHIFKEKVDIEIKRISEYYNLRTITWND
                     RVSMENIRGYLPVGISDTSNYICLNITGTIKAWAMNKYPNYGLALSLNYPYQILEFTS
                     SRGCNKPYILVTFEDRIIDNCYPKCECLPIRITGPMGPRGATGSTGPTGVTGPTGSTG
                     ATGSIGPTGPTGNTGATGSIGPTGVTGPTGSTGATGSIGPTGVTGPTGNTGVTGSIGP
                     TGATGPTGNTGVTGSIGPTGVTGPTGNTGEIGPTGATGPTGVTGSIGPTGATGPTGEI
                     GPTGATGATGVTGSIGPTGATGPTGATGVTGEIGPTGEIGPTGATGPTGVTGSIGPTG
                     ATGEIGPTGEIGPTGATGPTGVTGSIGPTGATGPTGATGEIGPTGATGPTGNTGVTGE
                     IGPTGATGPTGNTGVTGEIGPTGATGPTGVTGEIGPTGNTGATGSIGPTGVTGPTGAT
                     GSIGPTGATGATGVTGPTGPTGATGNSSQPVANFLVNAPSPQTLNNGDAITGWQTIIG
                     NSSSITVDANGTFTVQENGVYYISVSVALQPGSSSINQYSFAILFPILGGKDLAGLTT
                     EPGGGGVLSGYFAGFLFGGTTFTINNFSSTTVGIRNGQSAGTAATLTIFRIADTVMT"
BASE COUNT         1328 a          791 c          664 g         1646 t
ORIGIN      
        1 tttatataat attttttcac taaatttttt tctttttaca acaaatactc actacctttt
       61 gatataatat ttttatcaat tattattata ttcaagtttt gaaaggagta ttaaaatgag
      121 tttattagtt ttcggacata aaaatccaga tacagattca atatgttctg caatttcatt
      181 agcacattta aagaacaaac taggaataaa agcaacagct tatgctttag gagatatcag
      241 aaaagaagct aaatatgcct tggattactt taaggtagat gcacctgaaa ttttagataa
      301 tgttagaata caagttagag atttaaatta tgataaagta gtacctttaa caccaacttc
      361 atctatatta gaggcttata accttatgga tgaaaaaaat gttaaaacac tacctgtaac
      421 ttatgatgat ggaacttttg ctggtatcat tactatgaaa gaaatagcta aaaatctact
      481 tcatcaacac tttacaacta tacacacatc actatcaaac atttgtaaaa accttaatgg
      541 tactattctt gtggactgtg gtgaagatat aaaaggtaga gtagtcactt tatcatttgg
      601 aatggagact ctaatagaga ctttaaaaga aggagacata gctattgttg gagatagata
      661 tgatagtatt gaatatgcta ttgatacaaa agttaaactt ttaatactta ctaatcatac
      721 agagatttca aaagatttgc tagctcttgc taagataaat ggagtgtctg ttgtttctgt
      781 tgaaagtgac aattataaaa cttctaatgt aataaatcaa tgtagtttct tagactctat
      841 agaagctaca gaaaatttaa ttacattcaa agaagatgat tatatggatg aaataaaaga
      901 gattatgcta gaaacaaact tcagatctta tccaatatta gatgatgata ataagttttt
      961 aggtttagtt tcaaaaggtc atctattaaa cccatctaaa aagaatgttg ttttagttga
     1021 ccataacgaa tatgctcaaa gtgctgatgg aattgaacaa gcaaacatag ttgaaataat
     1081 tgaccatcat aaacttggtg gtatttctac tgatgttcct atgtcattta gagttatgcc
     1141 tgttggatgc aatagtacta taatttatca aatgtacaaa gaaaataatg ttgagatacc
     1201 ttatgaaata gccgggcttc ttttatctgc tatattatca gatacattat tatttaagtc
     1261 tccaacaaca actgatatag ataagaaagc ttgtgaagaa ttaagtaaaa tagcaaaagt
     1321 agacatggaa aaatacgcta tggatatgtt taaatgcggt acttctttag atgaatatac
     1381 tatagaagaa atagtaaata tggactttaa agaatttaat atgagtggac atagagttgg
     1441 tattggacaa gtatttacct tagacataga ctctatattt gctaaaaaag atgagttttt
     1501 atcttatata aattcgactg attatgacaa actaattctt gcggttacag atataatcaa
     1561 agaaggttct tatttaatct ataaagcaga agacagctta attgctaacg catttggtgt
     1621 tgaaggtgtt caaggtacat ttgcaccagg tgttgtatca agaaaaaaac aattagtccc
     1681 taatttaact actgcaatca aaaattttaa ataatataaa atttttaaat aacgaaaact
     1741 gtctcaaatc tatatttgag acagtttttt attatatata tatatattga taataaagtt
     1801 aaataaaaat ccataaattt aaaattttta tgaatatatt ttattattat tgttatttta
     1861 ttcattctaa aataggtaaa actcaatata taaaaatact tttgtcattt aaataaagcc
     1921 taaatagttt ttaagattat tttagacacg ttttaagtca taacagtatc agctattcta
     1981 aatatcgtca aagtagccgc agttcctgct gattgcccat ttcgtatccc tactgttgta
     2041 gatgaaaaat tatttattgt aaaagtagtc ccaccaaata aaaaaccagc aaaatatcca
     2101 gaaagtactc ctccgcctcc tggctcagta gtaagccctg ccaaatcttt tcctcctaaa
     2161 attgggaata ggatagcgaa agaatattga tttatacttg atgaacctgg ttgtaatgct
     2221 actgaaactg atatataata cacaccattt tcttgtactg taaacgtacc atttgcatct
     2281 actgttatac ttgaactatt tcctattatt gtttgccaac ctgttatagc atctccatta
     2341 tttagtgttt gtggagatgg tgcatttacg aggaagttag caactggctg agaggaattg
     2401 cctgttgctc ctgttggacc tgttgggcct gttactcctg tcgctcctgt tgctcccgtt
     2461 ggtcctatac ttcctgtcgc tcctgttgga cctgttactc ccgttggccc tatacttcct
     2521 gtcgctcctg tatttcctgt tggccctatt tctcctgtca ctcctgttgg gcctgttgct
     2581 cccgttggtc ctatttctcc tgtcactcct gtatttcctg tcggacccgt tgctcccgtt
     2641 ggtcctattt ctcctgttac tcctgtattt cctgttggac ctgttgctcc cgttggtcct
     2701 atttctcctg tcgctcctgt tgggcctgtt gctcccgttg gtcctatact tcctgtcact
     2761 cctgttgggc ctgttgctcc tgttggtcct atttctcctg ttggtcctat ttctcctgtc
     2821 gctcccgttg gtcctatact tcctgtcact cctgttgggc ctgttgctcc cgttggtcct
     2881 atttctcctg ttggccctat ttctcctgtc actcctgtcg ctcctgttgg acctgttgct
     2941 cctgttggtc ctatacttcc tgtcactcct gtcgctcctg ttgctcccgt tggtcctatt
     3001 tctcctgttg gtcctgttgc tcctgttggt cctatacttc ctgtcactcc tgttggacct
     3061 gttgctcccg ttggtcctat ttctcctgta tttcctgttg ggcctgttac tcctgttggt
     3121 cctatacttc ctgtcactcc cgtatttcct gtcgggcctg ttgctcccgt tggtcctata
     3181 cttcctgtca ctcccgtatt tcctgtcgga cctgttactc ctgttggtcc tatacttcct
     3241 gtcgctcctg tacttccggt tgggcctgtt actcccgttg gccctatact tcctgttgct
     3301 cctgtatttc cggttgggcc tgttggtcct atgcttcctg tcgctcctgt acttccggtt
     3361 gggcctgtta ctcccgttgg tcctgtactt cctgtcgctc ctcttggtcc cattggacct
     3421 gtaattctaa ttggaagaca ctcacattta ggataacaat tatctataat tctatcttca
     3481 aatgttacaa gtatatacgg tttgttacaa cctctactag atgtaaattc aagaatctga
     3541 taagggtaat ttaaagataa agctaaccca taattaggat atttattcat tgcccatgct
     3601 tttatagttc ccgtaatatt taaacaaata tagttggatg tatcacttat cccaactggt
     3661 aaatatcccc taatattttc catagacact ctatcattcc atgttatagt tcgtaaatta
     3721 taatattcac ttattctttt aatttcaata tctacttttt ctttaaaaat atgattctta
     3781 tttgaatcaa tatgaataaa taactctgct tttaatatac ttttgtcttt taatatatct
     3841 ggtattctca ctttaaaaaa agtaatcaac ttttctttta caaaactatt tgaacattta
     3901 cttcctatta agcaataatc taaattacta aagtttttat ctggatattt tttagatata
     3961 aaagtatcat catttaaata aagtataata tttctcattt ataatccctc cattttgggt
     4021 ctatatcata ctatgtttaa aatacatgct tagttacaat ataattaaaa tttatagtat
     4081 taaattttta tataataatg ctgatttcta caaaaaaaga acatgtcatt agaaatttct
     4141 aatagcatgt tctttttcat tattatatat tacactttaa attattcctt gactggctta
     4201 gctggtgtaa actaaaccag tctttctaaa atattaagca cttttttctt attatgtttt
     4261 ttaggattta ttgtctatat tattgtaaac caaagttata aaattgtaaa tagaatatat
     4321 taccataaca atatcttttt ataagtaaaa attataaaaa accttatttt tattaaatag
     4381 aataaataaa ataagtttaa aaaatactga aataagtgtt ttccacata
//
LOCUS       DAEQCW010000182         4372 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.183, whole genome shotgun sequence.
ACCESSION   DAEQCW010000182 DAEQCW010000000
VERSION     DAEQCW010000182.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4372)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4372)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4372
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.183"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            231..1310
                     /locus_tag="KRO40_003461"
     CDS             231..1310
                     /locus_tag="KRO40_003461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH2094254.1"
                     /translation="MPELLKNMYNRESLYEVAVAIQSVYNSFKVDEFIKSTMDETWNN
                     LELKARCRKISMSLGMYLPEDYKEALSILEKSVTGFYFAFFFPDFVEVYGQDDINWDL
                     SISALERNTEYWSSEFAVRAFIIKDEERMMAQMRKWSKHKSEHVRRLASEGCRPQLPW
                     GQAISKFKKDPTPVLPILEQLKTDTSTYVQKSVANNLNDISKTHPDLVISIAKDWYGK
                     NKSTNWIVKHGCRTLLKKGNRDVLALFGYDDTTSINIQDFTLETTSISIGEDLTFSFN
                     ILAKKATKTRLEYGIDYIKSNGKKSRKIFKISEVSLKENEKKSYMKKHSFADVSVRKH
                     YPGIHSIAIIINGIEKDKLDFELGI"
     gene            1634..2002
                     /locus_tag="KRO40_003462"
     CDS             1634..2002
                     /locus_tag="KRO40_003462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBH2094255.1"
                     /translation="MDVYSFWNDTLAQDAVKIRKYFHENAYINWHDTNEHFTLEEFII
                     ANCEYPDKWNGKVERVLEFGNLVITVTHVYAINKPLSFHVVSFISLKDDKIISIDEYW
                     GEDDDVPQWRLDKHIGKPIK"
     gene            2119..2922
                     /locus_tag="KRO40_003463"
     CDS             2119..2922
                     /locus_tag="KRO40_003463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBH2094256.1"
                     /translation="MEEKYILSDRGKVYYWIKESNSVFAKNLIFLPGLTANHHLFDFQ
                     IQYFSKNHNVLVWDAPAHGKSRPYLDFSYSNLVEELKVILDKQNMKKVVLIGQSAGGF
                     VAQSFIVKYPNMVEGLMMIGTCPYGTDYYSKSDIFWLKQTEWMLKLFPDKFLRNIISK
                     MCGATSEGRRSMLKMLEGYEKKELCHLMYLGFAGFIPEIQDLNIHCPVCLVVGDKDKT
                     GKVRKYNEQWHNKTGYPLHIIKNASHNVNVDKPNELNQIMDIFIKQLNI"
     gene            3307..4197
                     /locus_tag="KRO40_003464"
     CDS             3307..4197
                     /locus_tag="KRO40_003464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2094257.1"
                     /translation="MIESIPAKQILQKVKFDNTRWFGIDYNMNLYRGCSHGCIYCDSR
                     STIYNIENFDKVRYKENVIEILSKELRSKRKKGVVGIGAMSDTYNPFEKQLCITKQAL
                     DLISENHFGVSIDTKSSLVVRDIPILQKIKKNNSAIVKLTITTANDELSKKIEPYVNP
                     SSVRFEAVKELNDSGIFCGILLTPMLPFLTDTKDEIRAIVEKAHKANAKFIYCMYGVT
                     MRSGQREFFYEHLRDISPKLVLKYQKTYGLNYVCTVQNKDSCEKLLREECARYGILTD
                     MKEIIKAYKRSESYTQIKFF"
BASE COUNT         1666 a          474 c          823 g         1409 t
ORIGIN      
        1 cagtaaagta taaaattcta ttactataat aaaagataga actagaagtc tttatgaaag
       61 tgggaaaagt gtttatataa ataaatttat atagtttata gtttaacagt aggaaatatc
      121 gtatgagtga gaatatcgta ttttacataa agatttagca atatgacaca ctgttgtcgt
      181 gttctgtagg atatgattaa taaatcagat atgaaaggag agtgagtaat atgccagaat
      241 tactaaaaaa tatgtataat cgtgagtcac tttatgaagt tgcagtagct atccaatcag
      301 tttacaactc atttaaggta gacgagttca taaaatctac aatggatgag acatggaata
      361 acttagaatt aaaagccaga tgtcgaaaga taagtatgag tttaggaatg tatttaccag
      421 aagactataa ggaagctctt tccattcttg aaaaatcagt tacaggtttt tattttgctt
      481 ttttctttcc agattttgtt gaagtttatg gtcaggacga cataaattgg gatttatcta
      541 taagtgcatt agaaagaaat actgagtatt ggtcttcaga atttgctgta agagcattta
      601 tcatcaagga tgaagagcgt atgatggcac agatgcgtaa atggtctaag cataagagcg
      661 aacatgtacg aagacttgca agtgaaggtt gtcgtcccca gttgccttgg ggacaagcaa
      721 tatccaaatt taaaaaagac cctacacctg tactgcctat attggagcaa cttaaaacag
      781 atacatcaac gtatgtacaa aagagtgttg ctaataatct aaatgatatc tcaaaaacac
      841 atccagattt agtcataagc attgcaaagg attggtatgg taaaaataaa tccactaact
      901 ggattgtaaa gcatggttgt agaactctgc taaaaaaagg aaatcgtgat gtattagctc
      961 tttttggata tgatgatact acttcaataa atattcagga ttttacttta gaaacaacgt
     1021 ctatttctat tggagaggat ttaacttttt catttaatat tttagcaaaa aaagcgacaa
     1081 aaacaaggct cgagtacgga attgattata ttaaatctaa tggaaaaaag agtaggaaga
     1141 tatttaaaat atcggaggtt tcattaaaag aaaatgagaa aaagtcatat atgaaaaaac
     1201 attcatttgc agatgtaagt gtaaggaaac attatccagg tatacactcg attgctatta
     1261 ttattaatgg tatagaaaaa gataaacttg attttgaatt aggtatataa ttttactaac
     1321 agaataatct atatcagata ctttgctaaa cttatataat atattttact aaatttatat
     1381 taggtagttt actacttgtt tactgaattt aaatacaaag aaatccaggt gttaatccct
     1441 gccgattaaa ggaatatgag cataacacaa aagtagaact tatcaattct gttacgggta
     1501 tagtagtaaa tccatagaat cacaattaga agatgaagtg taaaaaataa gttagtgttg
     1561 attttagttg ctagtgatat tgaatagtta tgcaataccc atataaatta gaatttgtag
     1621 aggagaaatg taaatggatg tatatagttt ttggaatgac actttggcac aagatgctgt
     1681 taagataaga aaatattttc atgaaaatgc ttatattaat tggcatgata caaatgagca
     1741 ttttacttta gaagaattta ttattgcaaa ttgtgagtat cctgataaat ggaatggtaa
     1801 agtagaaagg gtgctagaat ttggaaattt agtaattaca gtgacacatg tttatgcaat
     1861 aaataaacca ctatcatttc atgtcgtttc atttatcagc cttaaagatg ataagattat
     1921 ttctattgat gaatattggg gagaggatga tgatgtgcca cagtggagat tagataaaca
     1981 tattggaaag ccaataaaat agtgtttgtt ctgttttata actgaaattt tgataacatt
     2041 tgatattttg atttgtcatt ggtcaacata gtcgttagtg taataattta aaaaagtaga
     2101 atttggagag tgaacactat ggaagaaaaa tacatcttat ctgaccgagg gaaagtatat
     2161 tattggataa aagaaagtaa tagtgtgttt gcaaagaact taattttttt gccaggacta
     2221 acagcaaatc atcatctttt tgatttccaa atacagtact tttcaaaaaa tcataatgta
     2281 ttggtatggg acgctcctgc tcatggaaaa tcaagacctt acttagattt ctcatattct
     2341 aacttggtag aagaattgaa agtaatttta gataaacaaa atatgaaaaa ggttgtactt
     2401 atagggcaat cggcaggggg atttgtggca cagtccttta ttgtaaaata tccaaatatg
     2461 gtagaaggat taatgatgat tggaacttgt ccatatggaa ctgactatta tagtaagtca
     2521 gatattttct ggttaaaaca gactgaatgg atgttaaagt tattcccaga taaatttttg
     2581 cgaaacataa tatctaagat gtgtggagct acgtctgaag gcagaaggag tatgctgaaa
     2641 atgttagaag gctacgaaaa aaaagaactg tgtcatctca tgtatctggg atttgctggg
     2701 ttcataccag aaattcaaga cttaaatata cattgtccag tttgtttggt ggttggagat
     2761 aaagacaaga cgggtaaagt gagaaaatat aatgagcagt ggcacaataa gactgggtat
     2821 ccattgcaca ttataaaaaa tgcttcacat aatgtaaatg tcgataaacc taatgaacta
     2881 aatcagatta tggatatatt tattaagcaa ttaaatatat aaaaactaca tactcattag
     2941 gtaaattatg tagtatatgt gtttacagat ggttatagaa ataaatatgt aataaactac
     3001 ttaacactta aaaagtggat ttgtccagag cataatacaa agcatgatat ataaattttt
     3061 aagcgaaata catcaaaaga agtattagaa ttagtggaga taaaacagct attagagatt
     3121 ataaataaat agttttaaag gtactacgaa tatagaggaa ggtaaatcat acgttattca
     3181 aggattataa atgattagtt taaaagtact atcggatagg tctctgcata tttaaacctt
     3241 agtaaaggta gttaaagtag tagtttaaaa actaaaaaat tatataaagg aattaggtat
     3301 aagaaaatga ttgagagtat accagcaaaa caaattttac aaaaagtgaa atttgacaat
     3361 acaagatggt ttggaattga ctataatatg aatctctatc gtggttgttc tcatggatgt
     3421 atatattgtg atagccgtag cacaatatac aacatagaga attttgacaa agttagatat
     3481 aaagaaaatg tgatagaaat tttaagtaaa gaattgcgtt caaaaagaaa aaaaggtgta
     3541 gtaggcattg gagctatgtc tgacacatat aatccttttg aaaagcaact ttgtattaca
     3601 aagcaagcac tagatttgat ttcggaaaat cattttggag tgtctattga tactaaaagt
     3661 agtttggtgg ttagagatat accgattttg cagaaaatta aaaaaaataa ttctgctatt
     3721 gtaaagttga ctataaccac tgcaaatgat gaattatcaa agaaaataga accttatgta
     3781 aatccaagtt ctgtacgatt tgaggcagtg aaagaactta atgattctgg aattttttgt
     3841 ggtatattat taactcctat gcttccattt ttgactgata ctaaagatga aatacgagca
     3901 attgtagaaa aagcacacaa ggctaatgca aaatttattt attgcatgta tggtgtaaca
     3961 atgcgtagtg gtcagagaga gtttttttat gagcatttaa gagatatatc accaaaattg
     4021 gtacttaaat atcagaaaac atatggttta aactatgtat gtactgtaca aaataaagat
     4081 tcttgtgaga agttgttaag agaagaatgt gcacgttatg gtattttgac ggatatgaaa
     4141 gagattataa aagcgtacaa gaggtcggag tcatatactc aaataaaatt tttttaagat
     4201 aggctttgga tgagatataa tagtggtgat tgatgtgttg atattatagt tgattgttag
     4261 agaggatatt atagatgaat attagtattg atattctagg taattgctag agttagtatt
     4321 atagatgaat attaatattg atattctagg taattgctag agttagtatt at
//
LOCUS       DAEQCW010000183         4334 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.184, whole genome shotgun sequence.
ACCESSION   DAEQCW010000183 DAEQCW010000000
VERSION     DAEQCW010000183.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4334)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4334)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4334
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.184"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(728..1138)
                     /locus_tag="KRO40_003465"
     CDS             complement(728..1138)
                     /locus_tag="KRO40_003465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094258.1"
                     /translation="MKIKKSLISAMMVSAMVLGGTGAVFANGNDSSNIALPKFESLIK
                     SGITDPTELEKYGVEHYTYEEYAKHIQELKDYAKDPNAVKDVSQKDLEETIKKMEQEL
                     EKIKTEGLKIMKPITIENEDGSQISIAYNYAAID"
     gene            complement(1354..2736)
                     /locus_tag="KRO40_003466"
     CDS             complement(1354..2736)
                     /locus_tag="KRO40_003466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBH2094259.1"
                     /translation="MFIKLLEMSFTSGVLLLIVIFIRACLFKKLPKKVFVLLWLIVLF
                     KLLIPVSLNSGFSIYSIIESTFDVELGNTSTENYTLKKASDSTGKNNSDEFEIMSNIE
                     NIMMLEMLGILSFIVTIMFSILLCFRYFKIINLFKTSIHIKNHEFIKKWMCKNSRFRR
                     FIVCISEFTRTPLTSGILKPRIILPKQMNYANNQTLDFVLTHEMVHINSFDNLLKLFM
                     LVALVVHWFNPLVWVMFFLLNKDIEFSCDEKVMSILGEEYRADYATTLISLAEENNPF
                     SMTICSGFGKTKIEKRIVNIMKFKKSTYVTFLVSTVLVCGTGLVFATENKEINEVESF
                     GLTKNEQSDKIGFSISSKSTDLYSPKVESDILVSKAKSDGETHFSTAKVSVIEFREHE
                     ESSMSKVTNSENSEETYVNKSSNSKDVLYTDSGEVSIERSGYNDNRFVISRKGNLLAV
                     NKEQYRTWIE"
     gene            complement(2747..3106)
                     /locus_tag="KRO40_003467"
     CDS             complement(2747..3106)
                     /locus_tag="KRO40_003467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2094260.1"
                     /translation="MEIKLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYT
                     VIKKLVSKGAIERIEPNFVCKALISKEEVQKQETETLINKMFGGSSEKFLSAFINKEN
                     LSSDEITKLKQIVEKLK"
     gene            complement(3311..4090)
                     /locus_tag="KRO40_003468"
     CDS             complement(3311..4090)
                     /locus_tag="KRO40_003468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HBH2094261.1"
                     /translation="MVSRQELKRVSKAQLSGNWGICAISMAVYIALIVLISIVGLPFE
                     PLTTIVVAVIAFCVSAGFTCMFLKITKDEKVKIGDIFVSGRIYLRSFGFYLFESIIVY
                     IYSFIITIIGAFLSFGVLLTSGAIEYLSSDNVGIGTIISTGITLVLIILVLMLPVYIL
                     LLYVSQATFLICEDKDNMGVFKSMGASLDMMKGNVLKLFVLNFSFIGWYILSIATLGI
                     GLLWLIPYVGVTNCNFYRQLVKENPDVEDILLDKEKSYTMY"
BASE COUNT         1529 a          713 c          398 g         1694 t
ORIGIN      
        1 tatttttttc tggtattctt atctactatt atccgtatat ttattttatg attactcttt
       61 taacctaccc cctatacttt atagtaatat gtttttaacc tttttcatta ttcccaatat
      121 gctttataac tacaaatact ctcccccctt aaaaataata ataaaattaa tcaataaatt
      181 tataatcata ttattactct atgtattaag caattactat gccaataaac tttgattttt
      241 ttaaacaaat cttaaaaatc ctaaaatgct aattttcttt aacttttaat gaatctaata
      301 gataacattt aattttcgtt atacttttca gaatatttct attattattt ttaagaaaaa
      361 aaaataatgt taacatttct taacatacat taaaaaatgt taacattata aattgggttt
      421 aatactttta ctttgactcg atttactttt attctacttc ttactttatt tttaacttag
      481 actttatttt tttattactt atttgagtct tatttatttt attctcactc catatgttca
      541 attacatttg tctaaattct ttgatacttt tattacataa ttttaacaag cttaagtgtt
      601 atttgggtag tgcagttgat aattatttaa ataatcatca actgcatgtt tatatcatta
      661 cagtagctta atgtatttaa tcatacttac ttaggatttt gaaatatctt agagattata
      721 tttaacatta gtcaattgct gcataattgt aagcaattga aatttgagac ccatcttcat
      781 tttctatagt gataggcttc ataattttta atccttcagt ttttatcttt tctaattctt
      841 gttccatttt cttaattgtt tcctcaaggt ctttttgact tacatctttg actgcattag
      901 ggtctttagc atagtctttt aattcttgaa tatgtttagc atactcttca taagtataat
      961 gctcaacacc atacttttcc aattcagtag ggtcagttat tcctgatttt attagagatt
     1021 caaatttagg taaagcaata ttagatgaat catttccatt tgcaaatact gctccagttc
     1081 ctcctagtac cattgcagat accatcattg cacttataag ggattttttt attttcataa
     1141 ccaatcttcc tttcttagag atttatttgg gtagtgtagt ttaaaatgac tattgcaata
     1201 gttatcaacc acattcttag actatcacag tagtcatgtt tatgtcaagc ctttttaaaa
     1261 aacttttcaa taaaaaatac tatctcaaaa caaaattaat tattttgaga tagtatttta
     1321 attctaaatc ttttatatta ctaagattta tggttactct atccatgttc tatattgttc
     1381 tttattaact gctaacaaat tcccttttct tgatatgaca aagcgattat cattatagcc
     1441 acttcgctca attgaaactt ctcctgaatc agtataaagt acatccttac tattactaga
     1501 tttatttaca tacgtttctt cactattctc agaattagtt actttgctca tagatgattc
     1561 ttcatgctct ctaaattcaa ttacagatac ttttgccgta ctaaaatgag tctctccatc
     1621 acttttagct ttactaacaa gaatatcaga ttctactttg ggagaatata aatcagttga
     1681 tttactactt attgaaaatc caattttatc actttgttca ttttttgtta aaccaaaaga
     1741 ttcaacctca ttaatctctt tattttctgt tgcaaaaaca agacctgtcc cacaaactaa
     1801 tacagttgaa actaaaaaag taacataagt tgatttttta aatttcataa tattaactat
     1861 tctcttttct atttttgtct ttccaaatcc actacatatt gtcattgaaa atggattatt
     1921 ctcctctgct agacttatta gtgtggttgc ataatcagcc ctatattctt caccaagtat
     1981 actcataacc ttttcatcac aactaaattc tatgtcttta tttagtaaaa aaaacatcac
     2041 ccagactaag ggattaaacc aatggacaac aagagctaca agcataaata actttaacag
     2101 attatcaaag ctattaatat gaaccatttc atgagttaaa acaaagtcta aagtttgatt
     2161 attagcataa ttcatttgct ttggcaaaat aattcgtggt tttaaaatac cagatgtaag
     2221 tggtgtccta gtaaattcag atatgcaaac aataaatctt ctaaaacggc tattcttaca
     2281 catccatttt ttaatgaact catgattttt tatatgaatt gaagttttaa aaagattaat
     2341 tattttaaaa tatctaaagc ataaaagtat gctaaacata atagtaacta taaaagacaa
     2401 aatgcccaac atttccaaca tcataatatt ttcaatatta gacattattt caaattcgtc
     2461 agaattgttt ttacctgtag agtcactagc tttcttaaga gtataatttt ctgttgatgt
     2521 attacccaat tccacatcaa aagtcgattc aattatacta taaatactaa aaccagaatt
     2581 taaacttact ggtattagaa gtttaaataa aacaatcaac cacaataata caaatacctt
     2641 tttaggtaat tttttaaata aacatgctct tataaaaata actattaaaa gtaatactcc
     2701 agaagtaaaa ctcatttcta acaatttaat gaacataaat cttacctcac tttaattttt
     2761 caacaatttg tttaagtttt gtaatctcat cacttgaaag attttcttta ttaataaaag
     2821 ctgaaagaaa tttttctgaa gaccctccaa acattttatt aattaaagtt tctgtttcct
     2881 gtttttgtac ttcctctttg cttattaaag ctttacaaac aaaattcggc tcaattctct
     2941 ctattgcacc ttttgacact aattttttta taacggtata cgtagtgttt ctattccatc
     3001 ctgtttcttc ttttaaaatt tttactaact ctccagcctt gctttctcct ctctcccata
     3061 gaacttccat tactttaagt tctgaatcaa ataattttat ctccatataa aatcgctcct
     3121 caaatatagt tatcacaata gtcattacta taataaaaaa ctatcatagt agtctatact
     3181 atgtcaatca tttatttttt aataataaaa actgtctttt taaaaaattc ttataaaaga
     3241 cagttttatc aatgttatac tttaatgttt aattaaagcc atattttatt taaatataca
     3301 actatctatc ttagtacata gtataagatt tttctttatc taatagtata tcctctacat
     3361 ctgggttttc ttttactaat tgtctataaa aattacaatt agtaacaccc acatatggaa
     3421 ttaaccatag tagacctatt ccaagagtag ctattgaaag tatataccat cctataaaac
     3481 taaagtttag tacaaataat ttaagtacat ttcctttcat catatctaaa ctagcaccca
     3541 ttgatttaaa tacacccata ttatccttgt cttcacaaat taagaaagta gcttgagaaa
     3601 catataatag caatatataa actggtaaca taagaacaag tattataaga actagagtta
     3661 ttccagtaga aataatagtc cctattccaa cattatcact tgataaatat tcaattgctc
     3721 cactagtaag taaaactcca aatgataaaa acgctcctat aattgtgatt ataaaagaat
     3781 aaatataaac aataattgat tcaaataaat aaaaaccaaa acttcttaaa taaattctcc
     3841 cacttacaaa gatatctcct atcttgactt tttcatcttt agtaattttc aagaacatac
     3901 atgtaaatcc tgctgaaacg caaaaagcta ttacagccac tacaatagta gtcaatggtt
     3961 caaaaggtaa tcctacaatt gatattaata ctatcaatgc aatatatact gccatagaaa
     4021 ttgcacatat cccccagttt ccagataact gagctttaga tactcgtttt aattcttgcc
     4081 ttgataccat aaaaaacacc cctttcattt tataaaaaaa cttttaaaaa tataaataat
     4141 cttttaacgt ataatattaa tatatcatat tttcgactat ataagataca attattcacc
     4201 atgttttatc aagatatgcc ataattgtat tactagtttt atatagtcaa cattaccaaa
     4261 tacatcaaat aaatttgatt aattattcaa caagtaataa aataatttct attaattata
     4321 ctttatttag taaa
//
LOCUS       DAEQCW010000184         4273 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.185, whole genome shotgun sequence.
ACCESSION   DAEQCW010000184 DAEQCW010000000
VERSION     DAEQCW010000184.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4273)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4273)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4273
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.185"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(223..1266)
                     /locus_tag="KRO40_003469"
     CDS             complement(223..1266)
                     /locus_tag="KRO40_003469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH/Band 7/PHB domain protein"
                     /protein_id="HBH2094262.1"
                     /translation="MGTKIVLSIVLIVVVVAISLTCIRVIKQSKVGIIMRLGKFQKVA
                     ETGVHFLIPFLDKMAYVIDLREIVIDFPPQPVITKDNVTMQIDTVVYYKVTDPVRYVF
                     EIANPIAAIENLTATTLRNIIGELDLDETLTSRDIINVKMRTILDEATDKWGIKVNRV
                     ELKNIMPPQDIQVAMEKQMRAERERREAILQAEGNKSAAILQAEGEKQSAILTAEAKK
                     EAMVRVAEGEKESAILVAEGEAEAIRQTAIAKAQGEAEMIKRTQMATAEGLKLVFSAM
                     KEADIDNNILALKSMEALEKMAEGKSTKLVLPSEAVNFLGTFKGIKEVMSDDNKEVLD
                     IKEVLNDNESLKK"
     gene            complement(1287..1733)
                     /locus_tag="KRO40_003470"
     CDS             complement(1287..1733)
                     /locus_tag="KRO40_003470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NfeD family protein"
                     /protein_id="HBH2094263.1"
                     /translation="MKLIWLIVAVLFGIAEMLTPSLTLIWFSVGAVILIFLSSFIESI
                     FLQILIFAVISIAMLVVATKKIVKKDKGYKSNTNLQAMMSKKGIVTEEISPNNTGLVV
                     VEHETWTAISIDGEKIEKGSTVEVLKIEGVKLVVKKVDATVNVTNQ"
     gene            complement(1907..3487)
                     /locus_tag="KRO40_003471"
     CDS             complement(1907..3487)
                     /locus_tag="KRO40_003471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional ADP-dependent NAD(P)H-hydrate
                     dehydratase/NAD(P)H-hydrate epimerase"
                     /protein_id="HBH2094264.1"
                     /translation="MLIGTSKLSRNVDTACVEEVGIPMIVLMENAVISAMKNMDIDMY
                     NSYTVVCGVGNNGGDGLGIARHLNTYGKEVNVFLVGNLEKLSECSKINYNVLLNMGIN
                     IININKNDLSEKNYGDENEVDKIIKVEKQNIIKNKNLTIFKDRVSKSDVVVDAIFGTG
                     LKRDITGIFKEVIDIVNDNSKNTYSIDIPSGIDSDNGNVLGTCIRANKTISFEFYKRG
                     FLNYDTSALIGDVVVEKIGVPDFITRKYHDEEFITDKTFVKNNIRRRDKHGFKSDFGK
                     VSIVAGSKGFYGASFIATESAVKSGSGLVTLISSEDVQEKVSIRLTEAMTLNFEEERL
                     NKLLNSSDAIGFGPGMGDNSQTFDKLLKIVENSNCPIVLDADGLNVMKDRCYKFLEWK
                     NRFVITPHLGEMARLTGDSIGYIREHRVDVAKEFAQKYNLVVLLKGYQTVITDGKKTY
                     INPTGNSCMATGGMGDCLLGMITSFIGQGMDILEATVSGAYIHGYIGDKLSKAMYTIN
                     ATDLISNISLTMKELLDI"
BASE COUNT         1387 a          753 c          399 g         1734 t
ORIGIN      
        1 ctatatgttt tatataatat tatataacac tttttacatt agtaaaggat aaattgtata
       61 aagattctgt taatttattt ttataatttc atctttctaa taaaaacaaa gaagaagact
      121 taaaaattta taagtcctct tcttttcaac gtgcattttt gtgctatatt taattaattc
      181 gacctttaat ttccatatcc ttcctatgat aacaaaactc ttttattttt ttaatgattc
      241 attatcattt aaaacttctt ttatatcaag tacttctttg ttatcatcac tcataacttc
      301 ctttattcct ttgaatgttc ctaggaaatt aactgcttct gaaggtaaaa ccagttttgt
      361 tgacttacct tcagccattt tttcaagagc ttccatagat tttaatgcta gaatattatt
      421 gtctatatca gcctctttca ttgctgaaaa aactaatttt aaaccttctg ctgttgccat
      481 ttgagttctt tttatcattt cagcttcacc ttgtgcctta gcaatagctg tctgtcttat
      541 agcttcagct tcaccttctg ccactaatat agcagattct ttttcacctt ctgctacacg
      601 taccatagct tcttttttgg cttctgctgt taatatagca gattgttttt caccttcagc
      661 ttgaagtatt gcagctgact tattaccttc tgcttgaagt attgcctctc ttctttctct
      721 ttctgctctc atttgttttt ccattgcaac ttgaatatcc tgaggaggca ttatattttt
      781 taactctact ctatttactt ttatacccca tttatctgtt gcttcatcaa gaatagttct
      841 catttttaca tttattatat ctcttgatgt taatgtttca tctaaatcaa gttcaccaat
      901 tatatttctt agtgttgtag ctgttaaatt ttcaatagca gctattggat tagctatctc
      961 aaacacatat ctaactgggt ctgtaacttt ataatataca actgtatcaa tctgcatagt
     1021 tacattatct ttagttataa ctggttgagg tggaaaatct attacaattt ctctaaggtc
     1081 aattacatat gccattttat ctaaaaatgg tattaagaaa tgtacacctg tttcagctac
     1141 tttttgaaac ttaccaagtc tcattattat acctacttta gattgtttta taactcttat
     1201 acaagttaaa cttattgcta cgactactac tattaataca atacttaaaa caattttagt
     1261 acccatacta taaatcctcc tttattctat tggtttgtca cattaactgt ggcgtctact
     1321 tttttaacaa ctaattttac cccttcaatt tttaatactt ctactgtaga acctttttct
     1381 atcttttcac catctataga aatagccgtc catgtttcat gttcaactac aactagacct
     1441 gtgttatttg gagaaatctc ttctgtaaca ataccttttt tagacatcat tgcttgtaaa
     1501 ttagtgttag atttatagcc tttatctttt tttactattt ttttagtagc tacgactaac
     1561 attgctatag aaattactgc aaatattaaa atttgtaaga aaatactctc tataaagcta
     1621 cttaaaaata taagtattac agctcctaca ctaaaccata tcaatgttaa gcttggtgtt
     1681 aacatttctg ctattccaaa taagactgct actatcaacc atattaactt catactatct
     1741 accctctttt catatgaatt ataaaaccct atataaatta tatgtttata caatgttttt
     1801 gaatataaat ttaaattaca aaacaataaa ataaattaat taattaatag tattatatca
     1861 acatactttg ttaaaattgt tacaaagtag tatcaaatat caccaattat atatccaaca
     1921 actctttcat tgttaatgaa atgttactta ttaaatccgt agcatttatc gtatacattg
     1981 ctttgctcaa tttatctcct atatagccat gtatatatgc tccactaact gtagcttcca
     2041 atatatccat accttgacct ataaatgaag taatcattcc aagcaaacaa tcacccattc
     2101 caccagttgc catacagcta tttcctgtag gatttatata tgttttttta ccatctgtta
     2161 tgacagtttg ataacctttt aaaagcacca ccagattata tttttgagca aattcttttg
     2221 caacatctac tctatgttct cttatatacc caattgaatc tcctgtcaac ctggccattt
     2281 ctcccaaatg aggtgtaatt acaaatctat ttttccattc taaaaactta taacatctgt
     2341 ccttcataac gttcaatcca tctgcatcta atactattgg gcaattagaa ttttctacta
     2401 tcttaagtaa tttatcaaat gtttgactat tatctcccat acctggacca aaaccaattg
     2461 catcactaga attaagtaat ttatttaatc tttcttcttc aaaatttaaa gtcattgctt
     2521 ctgtaagtct aatagatacc ttttcttgca catcttcact actaattaat gttacaagtc
     2581 cactcccact cttaacagca gattcagttg ctatgaaact tgcaccataa aatccttttg
     2641 aacctgcaac tatagatact tttccaaaat cacttttaaa accatgctta tctcttcttc
     2701 taatattatt ttttacaaaa gtcttatcag ttatgaactc ttcatcatgg tattttcttg
     2761 taataaaatc tggaacacct atcttttcta caactacatc acctataagt gcgctagtgt
     2821 catagtttag aaaacctctt ttataaaact caaagctaat cgttttgttt gctctaatac
     2881 aagttcctaa tacatttcca ttatcgctat ctatacctga aggaatatct atagaatacg
     2941 tatttttgct attatcgttt actatgtcaa taacttcttt aaaaatacca gttatatcac
     3001 gttttaatcc agtcccaaat atagcatcta ctacaacatc acttttagat actctatctt
     3061 taaaaattgt taaattttta ttttttataa tattttgttt ctcaacttta ataattttat
     3121 ctacttcatt ttcatctcca taattttttt cacttaaatc atttttatta atatttataa
     3181 tattaattcc catatttaaa agtacattgt aatttatttt agagcattca cttagttttt
     3241 caagattacc tactaaaaat acgtttactt cttttccata tgtatttaga tgtcttgcta
     3301 ttccaagacc atctcctcca ttatttccaa caccacatac aactgtataa ctattataca
     3361 tgtctatatc catatttttc attgcagata taaccgcatt ttccatcaat acaatcattg
     3421 gaatccctac ttcttctaca catgcagtat caacatttct gcttaattta gatgtaccta
     3481 ttagcataaa ttatcactcc tataaagtta aagacttctt aaatacttac caaaaatatc
     3541 tattgaaatc tttttaatcc cataaatatc ataaataaaa tcactaaaac taagagtttt
     3601 gaaataattt aaaataacaa aaaattttga attaaaacaa ttatttaatt tattatacca
     3661 tataatttaa gttattatgt tgatttaaaa cctatttaca ctaattatct aaatatctct
     3721 ttatttttat aatcttttat gacttattta tatttttcat ttttataaaa aaacaataat
     3781 taagaatata actatattct acatgtaaaa atttttttat ttaaactcaa ttttctgata
     3841 atttgataat ttttcaaaat ttatagttga cttttatttt ttactgtatt aaactaatta
     3901 ctatacaaaa cagaaaacaa aattttcaaa attattaaat taaaaggaga ggtaaatatg
     3961 aagactttat taaacaaaca agtacgattt tttagtagcc aatttagtta gggtttgtac
     4021 ctaagttaag acaaattgtc ataacataga tacaagcccc ttaggattat gatttttaag
     4081 gattgtatct atgttggcta tagtaattgt tgttaaagtt tttattttat catcataata
     4141 tagagccaca tggattatac tgtgtggctt attcgaattt ttgccataca gttatatata
     4201 ctgtgtggtt tttttatatc aaaatcattt tttaaaatca aatttaaaaa accatttaaa
     4261 atattttcaa agg
//
LOCUS       DAEQCW010000185         4243 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.186, whole genome shotgun sequence.
ACCESSION   DAEQCW010000185 DAEQCW010000000
VERSION     DAEQCW010000185.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4243)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4243)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4243
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.186"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..2619)
                     /gene="carB"
                     /locus_tag="KRO40_003472"
     CDS             complement(<1..2619)
                     /gene="carB"
                     /locus_tag="KRO40_003472"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBH2094265.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQALKEEGIEV
                     VLVNSNPATIMTDKEIADKIYIEPLTIEFIEKIIEKEKPDSLLAGMGGQTGLNLAVEL
                     HDAGILDKYNVKVIGTSIESIKKGEDRDLFREVMKEINQPVIVSDIVTNLEAGLEFAN
                     KIGYPVVVRPAYTLGGTGGGIADTEEELREILSHGLQLSPVGQVLLEKSIKGWKEIEY
                     EVMRDGNGNCITVCNMENVDPVGVHTGDSIVVAPSQTLSDEEYQLLRKASIDIINAIE
                     VQGGCNVQIALNPHSLEYAIIEINPRVSRSSALASKATGYPIAKVAAKIALGYTLDEI
                     ENAVTKKTYACFEPTLDYVVVKIPKWPFDKFRHANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHAPSEGRTLEELKARVVVPDDERLFDLAEMIRRGYKVEMISE
                     ITGVDKWFINKFKWIVEQEEKLKVLKIEDLDKEYLHELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIQPVYKMVDTCGGEFEALSPYYYSTYEQYDEVVVSDKRKVVVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMGIETIIVNNNPETVSTDFDTSDKLYFEPLTEEEVLNI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFRDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWTTNEGVEIAKELGYPVLVRPSYVLGGQGMEITYNEEKLIQYLDDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGY"
     gene            complement(2812..3861)
                     /gene="carA"
                     /locus_tag="KRO40_003473"
     CDS             complement(2812..3861)
                     /gene="carA"
                     /locus_tag="KRO40_003473"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002845470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBH2094266.1"
                     /translation="MKARLILEDGTVFIGKAFGYLEESVGEVVFNTSMIGYGEVLTDP
                     SYYGQIVTMTYPLVGNYGINLSSAESEKVQVKGFIVREKSDSPSNFRCEIDIDQYLKQ
                     NKVIGLEGIDTRALTKILRNNGTMKGIITLEDSKLEDVKHKLDKFSNTEAVRTVTRKE
                     VEHIKGNGPKVAVMDFGVKRNILRSFIARGCDITIFPATTSPEDVLSINPDLIFLSNG
                     PGDPEDLEDVIENIKALIGKKPIVGICLGHQLLALALGGKTAKLKFGHRGGNHPVKDL
                     EEGKVFITSQNHGYYVSEVPEQMKVTHINLNDNTVEGMRHEKLDVYSVQYHPEACPGP
                     KDNDYIFDKFLELVK"
BASE COUNT         1232 a          837 c          430 g         1744 t
ORIGIN      
        1 atatcctaaa tcctttaatt tagctcctaa catacactta gtagccaagt caactattgg
       61 tactccactt actttactta tatatggaac tgttctacta gctctagggt taacctcaat
      121 tatatataat tcattttgaa attctataaa ttgtatatta accataccaa gcacattaag
      181 gtctaaagct atttttttag tgtattctac tattttttct tttatttcat cagatatatt
      241 ttgacttgga tacattgttg tactatctcc agagtgaact ccagctcttt ctaaatgctc
      301 cattatacca ggtatcaata tatcttcttt atcacatata gcatctactt ctatttctct
      361 accagttaga tatttatcta taagtactgg atttttatgg tctctatcaa atgcatcatc
      421 caaatactga attagttttt cttcgttata agttatttcc ataccttgac caccaagtac
      481 ataagatggt ctaactaata ctggataacc taactcctta gcaatttcaa caccttcatt
      541 agttgtccat acaccttttc cttttggtct atttatatct agtctctcta gtaaatcatc
      601 aaatttttct ctatcttctg ctgcatctat atctctaaag tctgttccca gtataggtat
      661 atttttttca tgtaaaaact tagccaattt tatagctgtt tgtccaccaa actgtagtat
      721 tacaccttct ggtttttctt tttctattat atttaaaact tcttcttctg ttaatggttc
      781 aaaatacaac ttatcagatg tatcaaaatc cgtacttaca gtttcagggt tattgtttac
      841 aattatagtt tctattccca tttttcttaa agattttaca cagtgaactg aacaatagtc
      901 aaattctatt ccttgaccta ttcttattgg accagaaccc aatactacaa cttttctctt
      961 atcactaact actacctcat catattgttc ataagttgaa tagtaataag gtgatagagc
     1021 ttcaaattct cctccacatg tatcaaccat tttataaact ggttgtatat tatataaact
     1081 tctcaattca tataattttt ctgggcttat cttcattaag tcagatatac ctttatcaga
     1141 aaatcccttt ttctttaatt catgtaaata ttctttatct aagtcttcta tttttagaac
     1201 ttttaacttt tcttcttgtt ctactatcca tttaaattta tttataaacc acttatcaac
     1261 accagttatt tctgatatca tttctacttt atagcctctt cttatcattt cagctaagtc
     1321 aaatagtctc tcatcatcag gtactactac tctagccttt aattcttcta atgttctacc
     1381 ttctgatgga gcatgaacca atgaatattt tcctgtttca agtgatctta tacctttaag
     1441 aatagcagcc tcaaagttac ttcctatact catgatttca ccagttgcca tcatcttagt
     1501 tcctaatttt ctattggcat gtctaaattt atcaaatggc cactttggta tttttactac
     1561 cacataatct aatgttggct caaaacaagc ataagttttt ttagttactg cattttctat
     1621 ctcatccaaa gtataaccta aagctatctt agctgctact tttgctattg ggtatcctgt
     1681 agcttttgat gctagggctg atgacctact aactcttgga tttatttcta ttatcgcata
     1741 ttctaaacta tgtgggttta aagctatttg aacgttacat ccaccttgaa cctctattgc
     1801 atttattatg tctattgatg cctttctaag tagttgatac tcttcatcac ttagagtttg
     1861 acttggagca acaactatac tgtctcccgt atgaactcca actgggtcta cattttccat
     1921 attacataca gttatacagt ttccatttcc atccctcatt acttcgtatt ctatttcttt
     1981 ccaacctttt atactctttt caagaagaac ttgtccaaca ggacttagct gtagtccatg
     2041 tgaaagtatt tctcttaatt cttcctcagt atcagctata cctccaccag ttccacctag
     2101 cgtatatgct ggtcttacaa ctactggata tcctatctta ttggcaaact caagacctgc
     2161 ttctaaattt gtaactatat cactaactat tactggttga tttatttctt tcattacttc
     2221 tctaaataaa tctctatctt cgcccttttt tatagattct atagatgttc ctataacttt
     2281 tacattatat ttatctaata taccagcatc atgtaattct acagctaagt ttaatcctgt
     2341 ctgaccaccc atacctgcaa gtaaactatc tggtttttct ttttctatta ttttttctat
     2401 aaattctatt gttaatggtt ctatatatat tttatctgca atttctttat cagtcattat
     2461 agtagctggg ttactattta ctaatacaac ttcaattccc tcttctttta atgcttggca
     2521 ggcctgtgtt cctgaatagt caaactctgc agcttgacct attattattg gccctgaccc
     2581 taatactaaa gttttcttta tactatctaa tttaggcata actctttctc cttatctaaa
     2641 caattttcac agttcttatc ttcatcatct atacaatcaa ctttaattac tttattttat
     2701 cttaaattca aatttactca tcaatacatc tatttaatac atctatgtta attaaaccaa
     2761 actttttgat ttaagttatt cttgtttttt agttagctat tctaatgtta tttattttac
     2821 taattctaaa aatttatcaa aaatatagtc attatctttt ggtcctgggc aagcttcagg
     2881 atggtattga acactgtata catctagttt ctcatgtctc attccttcaa cagtattatc
     2941 atttaaattt atatgtgtca ctttcatttg ttcaggaact tctgaaacat aataaccatg
     3001 attttgagaa gttataaata cttttccttc ttctaaatct ttaactggat gatttccacc
     3061 tctatgccca aatttaagtt tagcagtttt tcctccaaga gctaaagcta aaagttgatg
     3121 tcctaagcat attccaacta taggtttttt accaataaga gcttttatat tttctataac
     3181 atcttctagg tcttctgggt ctccaggtcc atttgacaag aatattaagt cagggtttat
     3241 actcaataca tcttctggag atgttgtagc tggaaatatt gttatatcac atccacgagc
     3301 tataaatgat cttaatatat ttctttttac tccaaaatcc ataacagcca cttttggacc
     3361 atttcccttt atatgctcta cttcttttct tgtaacagtt ctaactgctt ctgtatttga
     3421 aaacttatcc aatttatgtt taacatcttc taatttactg tcttctaatg taattatacc
     3481 tttcatggtt ccattatttc taagtatctt agtcaaagct cttgtatcta ttccttcaag
     3541 tccgataact ttattttgct ttaaatattg gtctatatca atttcacatc taaaattact
     3601 tggagaatca cttttctccc ttactatgaa tccctttact tgaacttttt cagactctgc
     3661 tgatgataaa tttataccat aatttcctac aagaggataa gtcatagtaa ctatttgacc
     3721 atagtaagaa gggtctgtta aaacttcacc atatcctatc attgaagtat taaatactac
     3781 ttctcctaca ctttcttcta aatatccaaa tgcctttcct ataaaaactg ttccatcttc
     3841 taatattaac cttgctttca tactacagta cctcctataa ttctctttag acaaactaaa
     3901 gaacattaac taaatataag cttttaaata tctatatcta tttttcactt ttacattcta
     3961 gttttatact tatttacatt tattttttat ctttttctat tatactacaa atttcttaaa
     4021 aaaaagaagt tatctcaaaa gtaaaaactc ctagaaaaaa taacctcttt tttttattta
     4081 ataattaaat tcttaaacta tacaatcaac ttaatttcta ttcagctata ttgtaaactt
     4141 ttaactcatc tttatttaaa tgtttcttct taacttctac taaagctttt agtgtatcca
     4201 aagatgtcat tatttcagta gaaaattcaa tagctgttct tct
//
LOCUS       DAEQCW010000186         4223 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.187, whole genome shotgun sequence.
ACCESSION   DAEQCW010000186 DAEQCW010000000
VERSION     DAEQCW010000186.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4223)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.187"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            75..956
                     /locus_tag="KRO40_003474"
     CDS             75..956
                     /locus_tag="KRO40_003474"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH2094267.1"
                     /translation="MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCG
                     TTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGSNNTMLSVHMSQEAEKLGVDGLL
                     IITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
                     VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDL
                     VTKFFEGDIEGSKKLQLDMDALIAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEE
                     TNLNVLKQELTNFGFKF"
     gene            1381..2382
                     /locus_tag="KRO40_003475"
     CDS             1381..2382
                     /locus_tag="KRO40_003475"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HBH2094268.1"
                     /translation="MKKVNVAIVGATGMVGRTFLKVLEERNFPIENLFLFSSSKSAGS
                     KVMFCGKEYIVEELKETSFTGRGIQIALFSAGGSISEKYAPIAASNGILVVDNSSQWR
                     MNPDVPLVVPEVNPEAIKNHKGIIANPNCSTIQAMVPLKALDDKYKIKRVVYSTYQAV
                     SGSGVKGVEDLEKGMNGNPTGFYPHQISYNCLPHIDSFTENGYTKEEMKMVNETMKIL
                     DNYDLKITATTVRVPVKNGHSESINVEFNNPFELDDLVKTLEEAPGVVVVDNPAKNEY
                     PTAVEFDDRDEVFVGRIRRDFSVDNGVNLWVVADNIRKGAATNAIQIAEMALSYDLV"
     gene            2499..3386
                     /locus_tag="KRO40_003476"
     CDS             2499..3386
                     /locus_tag="KRO40_003476"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBH2094269.1"
                     /translation="MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCG
                     TTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGSNDTMHSVNLSQEAEKLGVDALL
                     IITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
                     VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDL
                     VAKFFEGDIEGSRKLQLGMDALIAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDP
                     ANLEVLKKELVNFGLKVNA"
     gene            3453..4202
                     /locus_tag="KRO40_003477"
     CDS             3453..4202
                     /locus_tag="KRO40_003477"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBH2094270.1"
                     /translation="MLKVIATGYDGKMGKILADTIREDNELELVCVAARGLDSYEGDL
                     KIYEDMSTIVEEADVVIDFSHHSNLDNILSYVLKTKTPLVIATTGYNDDEMNKIREAA
                     KVIPVFQSYNMSLGVNVLVKLVKDAAKLLEGFDIEIIEKHHNRKVDAPSGTAVMIANA
                     IKEVLPNVENNYGRYGRSAKRQPNEVGIHAIRGGNIVGEHDALFAGDNEVLTISHQAQ
                     SRGIFASGSIAAAKYLVKQKPGFYNMDSMLG"
BASE COUNT         1540 a          523 c          783 g         1377 t
ORIGIN      
        1 aattaattaa tttgtactat aattattatt gtacttaaaa aattaaattt agataaaaaa
       61 ggagatttga ttatatgtta tttaaaggtt ctgctgttgc tttagttacc ccatttacag
      121 aggataataa tgtcaacttt gaaaaattag gtgaattaat cgaatatcac attgagaatg
      181 gcacagatgc actagttgtt tgtggaacaa caggtgaggc gactactatg agtgaatctg
      241 aaatttttgc tgtaataaaa tatacagttg aaaaagttaa taagagaata cctgttatag
      301 caggtactgg ttcaaacaat actatgttgt ctgttcatat gagtcaagaa gctgaaaaat
      361 taggggtgga tggtctttta ataataactc cttactataa taagactaat gagaaaggtc
      421 ttaaacttca ctttgaaaca atagcaaata gcgttaagtt gccaattatt ttatacaacg
      481 taccaggaag aactaaagtg aatataaagc catctgttgt ggctgaactt gctaaaatag
      541 ataatatagt tgctgtgaag gaagcaagtg gagacttagc tcaagttgca gaaatagcta
      601 aattagtacc taaagacttt gctatatact ccggtaatga tgatactata ctaccactat
      661 tatcattagg tggaagtggt gttatctctg tacttgctaa catatgtcct aaagaaacac
      721 atgatttagt aactaaattc tttgaaggtg atattgaagg ctcaaaaaaa ttacaacttg
      781 atatggatgc tttaattgct gctttattta tagaagtaaa tccagttcct gttaaaactg
      841 ccatgaacat tttaggtttt aatgttggtg atttaagact tcctctagct gaaatggaag
      901 aaactaatct taatgtgtta aaacaagaat tgacaaattt tggatttaaa ttttagcaat
      961 atttatataa ataagttgat tttttcttaa atatgtatta ttattagaat aatcaaattt
     1021 taatatccta ttaacctagg gtagaggtag ctgtaactaa gagtatccaa tagtagctgg
     1081 caggtgttaa tgattggaaa aaggatttac agccgaagaa aatatttctt gcaataatat
     1141 tttctgggat tgcacataac atgtgtaata ctgtcactta tttttgtagg tgatgagcta
     1201 cagggtttac tttgagtgat aaattagacg tacaaagtat acctttgtac gttttttgta
     1261 tataattaaa gttgttaata taatattaaa gtttttggat atataaaaat attaacatat
     1321 cttacttgta taactaaaat aaaataatgt tttaataatt taaaattggg gtgaatttat
     1381 atgaaaaaag taaatgtagc aatagttggt gctactggaa tggtaggtag aacattttta
     1441 aaagtattag aagaaagaaa ttttccaata gaaaatctat ttttattctc ttcttctaaa
     1501 tcagctggtt ctaaagtaat gttttgtggt aaagaatata tagtagaaga attaaaggaa
     1561 acttcattta ctggtagagg catacaaata gcattattct ctgctggtgg aagtattagt
     1621 gaaaagtatg ctccaatagc tgcttcaaat ggaatcttag tagtagataa ctctagtcaa
     1681 tggagaatga atccagatgt gcctttagta gttcctgagg ttaatccaga agccataaaa
     1741 aatcataagg gtataatagc taatcctaac tgctctacta tacaagctat ggttcccctt
     1801 aaagctcttg atgataaata caaaattaag agagttgttt actctactta ccaagctgta
     1861 tctggttctg gtgttaaagg tgttgaagat ttagagaaag gaatgaacgg taatcctact
     1921 ggattctacc ctcatcaaat ctcttacaac tgtcttcctc atatagattc attcactgaa
     1981 aatggataca ctaaagaaga aatgaaaatg gtaaatgaaa ctatgaaaat acttgataac
     2041 tacgatttaa aaataactgc aactactgta agagttccag taaaaaatgg tcatagtgaa
     2101 tctataaatg ttgagtttaa caatccattt gagttagatg atttagtaaa aacacttgaa
     2161 gaagctccag gtgttgtagt agttgataat cctgctaaaa acgaatatcc aactgctgta
     2221 gaatttgatg atagagatga agtatttgtt ggaagaataa gaagagattt tagtgttgat
     2281 aatggtgtaa atctttgggt tgttgctgat aatataagaa aaggtgctgc aactaacgca
     2341 attcaaatag ctgaaatggc tttatcatac gatttagtat aatatacaaa cttgtataaa
     2401 tatataattt tgtaaaatat taatagtaac tcaaaaacaa gcattagaag taactgtaat
     2461 ataaaacaca aaaataaaaa agaggggatt gattttatat gatatttaaa ggttctgctg
     2521 ttgctctagt tacaccattt acaaaggata acaaagttga ttttgacaaa ttaggtgaat
     2581 tagttgaata ccaaatagct aatggtactg atgctatagt atcttgtggt actactggtg
     2641 aagctaatac tatgactgat gaagaacaac ttgctactat taagtatgtt gttgaaaaag
     2701 ttaataaaag agttcctgtt atagctggaa gtggttctaa tgatactatg cactcagtta
     2761 acttaagtca agaagctgaa aaattaggag tagatgctct attaataata acaccttatt
     2821 acaataaagc taataaagct ggacttaagc gtcattttga aacaatagct aacagtgtta
     2881 aacttccaat tatactttac aatgtccctg gaagaacttg tgtaaatata agtcctagcc
     2941 ttatagttga acttgctaaa attgataaca tagttgctgt aaaagaagct agtggagacc
     3001 taggacaggt tgcagaaata gctagtttag ttccagatga ctttgctatc tactctggta
     3061 atgatgatac tatacttcct ttattatctt taggaggtca aggagttata tcagtacttg
     3121 ctaatgtttg ccctcaagaa actcacgatt tggtagctaa attctttgaa ggcgatattg
     3181 aaggttctag aaaattacaa cttggtatgg atgctctaat cgcagcttta tttatagaag
     3241 taaatcctat accagttaag actgcaatga atttattggg attcaatgtt ggagatttaa
     3301 gattacctct agcagaaatg gacccagcaa atttagaagt attaaagaaa gaattagtta
     3361 actttggact aaaagttaat gcatagtaaa gattaatgca tggtaaaaag taagtttggt
     3421 caaaagttag cccttaatca taggaggaaa ttatgttaaa agttatagca actggttatg
     3481 atggaaaaat gggtaagatt ttagccgata ctataagaga agataatgaa ttagaattgg
     3541 tttgtgttgc agctagaggt ctggatagct atgaaggcga ccttaaaatt tatgaagata
     3601 tgagtactat agttgaggaa gctgatgtag ttatagattt ttctcatcac tctaatttag
     3661 ataatatctt atcttacgtt ttaaagacta aaacaccttt agtaattgct actactggat
     3721 ataatgatga tgaaatgaac aaaatacgtg aagcggctaa agttattcct gtattccaat
     3781 catataatat gtctcttggt gtaaatgtat tagtaaaatt ggttaaagat gcagctaaat
     3841 tactagaagg atttgatata gaaataatag aaaaacatca caacagaaaa gtagatgccc
     3901 caagtggcac agctgttatg attgctaacg ctataaaaga ggttttgcca aacgttgaaa
     3961 ataattatgg tagatatggt cgtagtgcaa aaagacaacc aaatgaagtt ggtattcatg
     4021 ctataagagg tggaaatatt gttggcgaac atgatgctct atttgctgga gacaatgagg
     4081 ttcttacaat aagccatcaa gctcaatctc gtggtatctt tgcaagtggt tctatagctg
     4141 ctgccaaata cttagttaag caaaaaccag gattttataa tatggacagc atgttgggat
     4201 aatagtataa atataataat aca
//
LOCUS       DAEQCW010000187         4174 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.188, whole genome shotgun sequence.
ACCESSION   DAEQCW010000187 DAEQCW010000000
VERSION     DAEQCW010000187.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4174)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4174)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4174
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.188"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            50..448
                     /locus_tag="KRO40_003478"
     CDS             50..448
                     /locus_tag="KRO40_003478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2094271.1"
                     /translation="MIKKIEHVVITNNNIENYINFYKKFGFSSKEMSKNYKLNARNVK
                     INLNIKGYKFLPYVKNSKASRDNLCFKINTNIDEPKKYLEQNEIQIERGIVECTGVFG
                     NIKSIYLKKTNGNLIELSNHRITESKPWKI"
     gene            436..1374
                     /locus_tag="KRO40_003479"
     CDS             436..1374
                     /locus_tag="KRO40_003479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBH2094272.1"
                     /translation="MENLILSINVVLPLFLTMSLGYVLKKLGLFDTHTLNKMNNVCFK
                     SFLPLLLFFNIYNTDLDGSLNFKLMAVAVIIIFSIFLILVFIIPKIEKDNKTRGALIQ
                     GVFRSNFVIFGIPVTISLFGDKSIGVTSLLIAVIVPMFNVLSVVILEIFRGGKVNIKH
                     MIKSVLTNPLIIASFIGLTMLILNINIPTFLHKTIGDISKIATPLSLIILGGSFSFSA
                     IKGHINPIILGVCGKLILVPAIFLPISIFLGFRNVELASLMIMLSAPTAVSSFTMAQQ
                     MDSDSELAGQIVVFTSGFSIITVFLIIFILKQNNLI"
     gene            complement(1758..1982)
                     /gene="secG"
                     /locus_tag="KRO40_003480"
     CDS             complement(1758..1982)
                     /gene="secG"
                     /locus_tag="KRO40_003480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HBH2094273.1"
                     /translation="MSNILMGVQVVLGILLVISIMPQDSKNALPSEFGGEGSQAYFKP
                     KGKQAFLARVTKITAVLFFINALALLIVKK"
     gene            complement(2553..3845)
                     /gene="eno"
                     /locus_tag="KRO40_003481"
     CDS             complement(2553..3845)
                     /gene="eno"
                     /locus_tag="KRO40_003481"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HBH2094274.1"
                     /translation="MSVIELVYAREVLDSRGNPTVEVEVVLEDGAMGRAIVPSGASTG
                     AFEAVELRDGDKGRYLGKGVETAVANVNEIIAPEIEGMDAFDQPAIDAIMIELDGTPN
                     KGKLGANAILGVSMAVARAAADEIGLPLFQYLGGVNAKQLPVPMMNILNGGEHADNNV
                     DVQEFMILPVGACCFKEGLRMGAEVFHSLKKVLGEKGLACGVGDEGGFAPNLGSNREA
                     LELIVEAITKAGYKPGEDVMLGLDVAATEMYNKETKKYVLAGEGKELTAAEMVALYED
                     WSNNFPIITIEDGLDEEDWDGWKLLTEKLGNKLQLVGDDLFVTNTERLEKGIENGVAN
                     SILVKVNQIGTITETLDAIEMAKRAGYTAVISHRSGETEDSTIADLAVAVNAGQIKTG
                     APSRTDRVAKYNQLLRIEEMVGEQARYCGLKSFYNLKK"
BASE COUNT         1452 a          665 c          456 g         1601 t
ORIGIN      
        1 tcaatctata taaaatttaa taacttatat aaaatcttaa ggagttgcca tgataaaaaa
       61 aatagaacat gtggtcatta ctaataataa tatagaaaat tatatcaatt tttataaaaa
      121 atttggtttt tcatctaaag aaatgagcaa aaattataaa cttaatgcta gaaatgttaa
      181 gataaatctt aacataaaag gttataaatt tttaccttat gttaaaaatt caaaagcaag
      241 tagagataac ttatgtttta aaataaacac aaatattgat gagccaaaaa aatacttaga
      301 acaaaatgag attcaaattg agcgaggaat tgtagaatgt acaggtgtct ttggtaatat
      361 aaaatctatt tatttgaaaa aaactaatgg aaatttaatt gaattatcaa atcatagaat
      421 cacggagagt aaaccttgga aaatttaatc ctatcaataa atgttgttct tcctttgttt
      481 ctcacaatgt cacttggata tgttctaaaa aaattaggtc tatttgatac tcatacttta
      541 aataaaatga ataatgtctg cttcaagtct ttcttgccat tattattatt ttttaatata
      601 tacaatacag atttagatgg ttctcttaat tttaagctta tggctgtagc tgttataatt
      661 attttttcaa tcttcttaat cttagtcttt attattccta aaattgaaaa agataataag
      721 acaaggggtg cattaataca aggtgtattt cgtagcaatt tcgttatatt tggtattcct
      781 gtgacaattt cactatttgg cgataagagt attggagtca catctttatt aattgcagtt
      841 attgtaccta tgtttaatgt attatctgtt gtaattcttg aaatttttag aggtggcaaa
      901 gtaaatataa aacatatgat taaaagcgtc ttaacaaatc cactcataat cgcctctttt
      961 ataggattga caatgctaat tttaaatatt aatataccta catttttaca caaaactatt
     1021 ggtgatattt ctaaaatagc tactccttta tcacttataa ttctaggcgg ctcttttagt
     1081 ttttctgcta taaaggggca tataaacccc attatattgg gcgtatgtgg aaaacttata
     1141 cttgtacctg ctatattttt accaattagc atttttcttg gatttagaaa tgtagaatta
     1201 gcttcactta tgataatgtt atctgctcca actgcagttt cttcatttac aatggcacaa
     1261 cagatggatt ctgacagtga attagctgga caaattgtag tatttacttc tggattttct
     1321 ataattacag tatttttaat aatatttatt ttaaagcaga ataatcttat ttaatgatat
     1381 ttgataacac aaattggtat tatgagaaac atatataaaa ttgatttaac tgcgtaaaaa
     1441 catattatta tactattttt actatataat ataactttgt gtatattatc tcattaaaca
     1501 tggtgaaaat agtgttgcta tatatttttt aatttgaaaa aaatatataa atacaaacaa
     1561 tatataaata taaataataa acgccaacaa atagtcaatc tataaaataa aaactggact
     1621 aatcatataa aatcattagt ccagctttta ttttacgtac tttttatgtt gatgtacttt
     1681 tattaaaaac taaatttaat ttttaaatgt ctagcaaatg cactaattaa ataatggcca
     1741 gttattcaac aatatcacta cttcttaact ataagtaatg ccaatgcatt tataaaaaat
     1801 aatactgctg ttatctttgt aactctagca agaaatgctt gttttccttt tggtttaaag
     1861 taagcttggc ttccttctcc accaaattct gaaggtaaag cattcttaga atcttgaggc
     1921 attatgctaa ttactagtaa aatccctagt actacttgca cacccattaa aatgttgctc
     1981 attcttgccc ctcctatctg tttattactt aaatttcatt actctttagt gtatcacaat
     2041 aatatagcca tttcaagact attatgctat aaataacata caaaaaaata tattgttact
     2101 ataatatatt actatattct caatataaaa atgaataaaa cttagaagag aaaactattt
     2161 aaattaatac ataaattaac acttaaaata atctactctc attgtatata ttataaatag
     2221 ccaccaaaat aaaacaatca ttttaaaata ttgatataac ttttaatttc aacataattt
     2281 aaaataaata atccacattt agcaataata cttcaatgac aattatgatt aaatcaaaat
     2341 atgtcttcac ttttattttt taataaaaac ctcctatgca attagataaa aatgagatag
     2401 aaacatttat tcatattttt tctgaatcta tgaataaaat taagtaataa aatataaaaa
     2461 aggataagtg aattgaaaaa tcaattaaca cttatctctt ttatatctta tattctctct
     2521 tcattaatct tttttagtaa ccattttaat aactattttt ttaagttata gaaagatttt
     2581 aatccacaat atctagcttg ctctccaacc atttcttcta ttcttaataa ttggttgtac
     2641 ttagcaactc tatcagttct tgatggagca ccagttttta tttgaccagc atttactgca
     2701 acagctaaat ctgctatagt agaatcttca gtttctcctg atctgtgaga tataacagca
     2761 gtatatcctg ctctcttagc catttctata gcatctaaag tttcagttat tgtacctatt
     2821 tgattaactt taactaatat agagttagct actccatttt caattccttt ttctaatctc
     2881 tctgtgttag taacaaataa gtcgtcacca actaattgta atttattacc taatttttca
     2941 gttaataatt tccatccatc ccaatcttct tcgtctaaac catcttctat agttattatt
     3001 gggaagttgt ttgaccaatc ttcatataaa gcaaccattt cagcagcagt taactctttt
     3061 ccttctcctg ctaaaacgta ttttttagtt tctttgttgt acatttctgt agcagcaacg
     3121 tcaagaccta acataacatc ttcacctggc ttatatccag cttttgttat agcttcaact
     3181 attaattcta aagcttctct gtttgaacct aagtttggag caaatccacc ttcgtcacct
     3241 acaccacaag ctaatccttt ttctcctaaa actttcttta atgaatggaa tacttctgct
     3301 cccattctta aaccttcttt gaaacaacaa gctcctactg gtaatatcat aaattcttga
     3361 acatcaacgt tgttatcagc atgctctcca ccgtttaata tgttcatcat tggaacaggt
     3421 aattgtttag catttactcc acctaagtat tggaataatg gtaaacctat ttcatcagca
     3481 gctgctctag ctactgccat tgaaacacct aatatagcat tcgctcctaa tttacctttg
     3541 tttggagttc catctaattc tatcatgatt gcatctatag ctggttggtc aaatgcatcc
     3601 attccttcta tttcaggtgc tattatttca tttacgttag caacagctgt ttctacacct
     3661 tttcctaagt atcttccctt atctccatct cttaattcaa cagcttcaaa agctcctgta
     3721 gatgctcctg atggaactat tgctcttccc attgctccat cttctaatac tacttcaact
     3781 tctacagttg gatttcctct tgagtctaat acttctctag catatactaa ttcaataact
     3841 gacatttgta tatctccctt cgattttcta ttagttaaat tttcatttac tgtaaacatc
     3901 cgtctactat tttaatctac tttctatatt atagtacata aagttgcttt tgaaaattag
     3961 gtacaaattt atttgatggg taaatttgta aaagttccta tttttatttt attttttata
     4021 atattttaat ttatataata taaaaaaact tgtctaaaat ccaaaaccaa tcttaaatac
     4081 acaaatatta taactagatt taaaacatta aacataaaat gtacaactaa tgcttctaaa
     4141 atttttgctt atataatata tattaattat tatt
//
LOCUS       DAEQCW010000188         4134 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.189, whole genome shotgun sequence.
ACCESSION   DAEQCW010000188 DAEQCW010000000
VERSION     DAEQCW010000188.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4134
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.189"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(150..1067)
                     /locus_tag="KRO40_003482"
     CDS             complement(150..1067)
                     /locus_tag="KRO40_003482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2268 domain-containing protein"
                     /protein_id="HBH2094275.1"
                     /translation="MVNMNIIEIRSDKIYKKIMDAPINKKEDIYRYELMKPFEFKWKC
                     MNVPIVARQKGGYDVIIASEMLGVLSPKDIDEKQKKNINVLSADKIWGTCKETIENSI
                     NAFIKEGYDLNIKDYKYSILLANPNSPYTILSDGYWGDGGIPGYIFLSLVPNEYTINR
                     LPVLIAHECNHNIRFQFIEWNNNITLEEMMINEGLAENFATWMFGEEMLGPWVSRTDI
                     ETLNTYIKPIIKSALKETGFRNITSYLYGDDIAKMQGYFPVGLPYCAGYACGYYMIKY
                     YLEKTNKSIIEATLLPYSEIIEAVKEFWE"
     gene            1329..1706
                     /locus_tag="KRO40_003483"
     CDS             1329..1706
                     /locus_tag="KRO40_003483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBH2094276.1"
                     /translation="MLTPYLIFNGTCEKAFNFYAEAFGGGKTIFARLDSNPNNPIMHA
                     SVTFTKYEGCIMGADTDKPVVISGMAICVVLPSREAIEEISVKLAEGGTLVQEFLPHP
                     PPHQNDGAAEVLDRYGYTWYLST"
     gene            complement(1862..2311)
                     /locus_tag="KRO40_003484"
     CDS             complement(1862..2311)
                     /locus_tag="KRO40_003484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2094277.1"
                     /translation="MKSGIILEMKQINSTEYDEMLQVWESSVRATHDFLTEKDIESLI
                     PLVEIGLKEVENIVCIKDNDIIKGFIGIDKDKIEMLFIEDKYRGNGIGKKLIKYAIDK
                     YNVKYVDVNEQNKKAVGFYIHLGFKVFDRSEIDGQGNPFPILHMKLI"
     gene            complement(2475..2879)
                     /locus_tag="KRO40_003485"
     CDS             complement(2475..2879)
                     /locus_tag="KRO40_003485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmaF family protein"
                     /protein_id="HBH2094278.1"
                     /translation="MSYQNYKCERDYVYDDYKYNKCNKCYNDYEEMTHVHEYSESVKL
                     AEECEDRHNHRAAGVTGEAIPINGGTNHVHKINDNVDFLDHFHKICVTTGPAIRIPGT
                     DKHIHLICGETTVNDGHCHKFLFTTQIEAPLV"
     gene            complement(2992..3858)
                     /locus_tag="KRO40_003486"
     CDS             complement(2992..3858)
                     /locus_tag="KRO40_003486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBH2094279.1"
                     /translation="MIDIHKNIYDNKLFEELKIDCKKCFGLCCVALYFSASDGFPIDK
                     ESGKPCINLQPDFKCSVHNSLMKRGFKGCTAYDCFGSGQKVAQVTYKGIDWMQSPELT
                     NQMSEVFLIMRQLHEMLWYLKEASVLNISDTIKSKIDLIIEETEKITNMGPEQIINLD
                     IISHRTKVNLLLSQASESVMGKVKSFIKTSTLKNMKKLSKNIDLIGADLRKINLIGAD
                     LRGRFLIAANLRNTDLSGANLIGADLRDCDIRGANLENSIFLTQLQVNTAKGDSSTKL
                     PASLIRPKYWEK"
BASE COUNT         1357 a          689 c          451 g         1637 t
ORIGIN      
        1 actctagata tgaaatctta aaacttttaa atattgaaat atttctttat atatattatt
       61 gtatatttct tataaattat tgtcaattta ttttttctta aaaataaaat aattgcataa
      121 tttatttcaa attatgcaat ttataaaatt tattcccaaa actcttttac tgcttcgatt
      181 atctcactat aaggcaataa agtcgcttcg attattgatt tatttgtctt ttctaaataa
      241 tacttaatca tataatatcc acaagcatat cctgcacaat aaggcaaccc tactggaaaa
      301 tatccttgca ttttagctat atcatcacca taaagataag atgttatatt tcgaaatcca
      361 gtttctttta aagcactttt tattattggc tttatataag tatttaatgt ttcgatatct
      421 gttctactga cccaaggtcc taacatttcc tctccaaaca tccatgttgc aaaattttct
      481 gcaagacctt catttatcat catttcttct aatgttatat tattattcca ctctataaac
      541 tgaaatctaa tattgtgatt acattcatgt gctattaata ctggtaatct attgatagta
      601 tattcattag gaaccaatga tagaaatata tatccaggaa tcccaccatc accccagtat
      661 ccatcactta atattgtata aggactattt ggattcgcca ataatattga atatttatag
      721 tccttaatgt ttaaatcata cccttctttt ataaaagcat ttatagagtt ttctatggtt
      781 tctttgcaag tgccccaaat tttatcagca gataacacat ttatattctt tttttgcttt
      841 tcatcaatat ccttaggcga taaaacccct aacatttcac ttgctataat tacatcatat
      901 ccacctttct gtctagcaac tattggaaca ttcatacact tccacttaaa ttcaaaaggc
      961 ttcatcaatt catatctgta tatatcttct tttttgttta ttggtgcatc cattatcttc
     1021 ttgtatattt tatctgagcg aatttctata atattcatat ttaccatctc ctttaagaca
     1081 aagtatatac aattacgtag cgtcaatgtc aatatacatt ttttataatg tcaccttaat
     1141 ctttttatta tattttatcc tgtaaacctt ccgtacatat aacatttttt taaattaata
     1201 aatttgtata atataataat aaaaaattat atacttcaag gtttccctat gatacaattt
     1261 actaaatcat aatttagatt atcaggtgca actataaatt attctatatc aaggaggata
     1321 tattggtcat gctaactcca tatttaatat ttaatggtac ttgtgaaaaa gcatttaatt
     1381 tttatgctga ggctttcgga ggaggaaaaa ctatatttgc gcgattagac agcaatccaa
     1441 acaatcctat tatgcacgca agtgttactt tcacaaaata tgaaggttgt ataatgggtg
     1501 cggatacaga caagcctgtt gtaatttctg gcatggcgat ttgtgttgtt ctaccatctc
     1561 gagaagcgat agaagaaata tctgtaaaac ttgccgaagg tggtacactt gtacaagaat
     1621 ttttaccaca cccaccacca catcaaaatg atggcgctgc tgaagtactt gataggtatg
     1681 ggtatacttg gtatttaagt acatagttaa aataaaaaaa ctacatctaa taatcataat
     1741 atagaacaga taaatttcaa tttaatagtg tagtaaaaaa gtcgtgtcct aagactgtca
     1801 cgacttttat ttgtataaaa atttaagtaa atatttttgc gaataaatga gaagtataac
     1861 tttaaattaa tttcatatgt agtattggaa atgggttacc ttgtccatct atttcagacc
     1921 tatcaaacac tttaaatcct aagtgaatat aaaatcctac agctttttta ttctgctcat
     1981 ttacatcaac atattttaca ttgtatttat ctatagcata ttttattaat tttttaccaa
     2041 taccatttcc tctatattta tcttctataa agagcatctc aattttatct ttatctattc
     2101 ctataaagcc ctttattata tcattatctt ttatacaaac tatattttct acttctttaa
     2161 gtccaatctc aactaatggt atcaaagatt caatatcttt ttctgttaaa aaatcatgcg
     2221 ttgctcttac tgatgattcc cagacttgca acatttcgtc atattctgtt gaatttattt
     2281 gtttcatttc aagaattatt ccagatttca taaaaatttc ctccctatat cacttttaat
     2341 tgcataacac ttttttatac aaaacttaga aaggactacg aaggttaaat atcatagtcc
     2401 tcattaagtt taaatattat ctattatata ttatactata atctagcaaa ttcactacaa
     2461 taattcacat cagcttatac taaaggtgct tctatttgag tagtaaaaag gaatttatga
     2521 caatgaccat cattaacagt agtttctcca catattaagt gaatgtgttt atcagttcca
     2581 ggtattctaa ttgctggccc tgttgtaaca catatcttat ggaaatggtc aaggaaatct
     2641 acattatcat ttattttatg aacatgattt gtacctccat ttattggtat agcttcacca
     2701 gtaacccctg ctgcacggtg gttatgtcta tcctcacatt cttctgctaa cttaacactt
     2761 tctgaatatt catgaacatg tgtcatttcc tcataatcat tatagcactt gttgcactta
     2821 ttgtatttat aatcatcata cacataatct ctttcacatt tataattttg ataactcatt
     2881 tttatatctc tccctatatt atattaagaa attcttgtaa agaatctcta atgtataata
     2941 tgaattaaag tcaaaaaagt tcatattttg taaaattatg tattaattta attatttttc
     3001 ccagtattta gggcgtatta gtgaagctgg taacttcgta ctagaatctc cttttgcagt
     3061 atttacttgt aattgtgtta aaaatatact attttcaaga ttagcacctc taatatcaca
     3121 atctcttaag tctgctccta ttaaatttgc cccactcaaa tctgtatttc ttaaatttgc
     3181 tgctattaga aatctacctc ttaaatctgc tcctattaga tttatttttc taaggtctgc
     3241 tcctattaaa tctatatttt tacttaattt tttcatgttt ttaagagtag aagtcttgat
     3301 aaatgattta acctttccca tcacagactc actcgcttgt gataataata aattaacctt
     3361 tgttctatgt gatatgatat ccaaattaat tatctgttct gggcccatat tagttatctt
     3421 ttcagtttct tcaattatta aatcaatttt tgatttgatt gtatctgata tatttaatac
     3481 agatgcttct ttaagatacc ataacatttc atgtaattgt ctcataatta aaaacacttc
     3541 agacatttga tttgttagtt ctggtgattg catccagtct atccccttat atgttacttg
     3601 tgctactttt tgacctgaac caaaacaatc atatgcagta caccctttaa aacctcgctt
     3661 cataagacta ttatgtacag aacatttaaa atctggttgt aaattaatac aaggttttcc
     3721 tgattcctta tcgataggaa atccatctga agcagaaaaa taaagagcta cacagcaaag
     3781 tccaaagcac ttcttacagt caatctttag ctcctcaaat aacttattat catatatatt
     3841 tttatgtata tctatcatat tttttctcct cttaaacttt atttttaata ttatattatc
     3901 tataactaaa tgataatcaa gtcccttatt taacagttct tattcttaat tataatttaa
     3961 ggtattattt attccaatag catacataag tttctttata cttgtaacaa tacctttata
     4021 ctaagactta ttttaaatgt agcactgtaa taataaattg tttatatact cataatgtat
     4081 ttgataaatt gtaaatcttt atagaagttg aaatttttaa tgattttaga atca
//
LOCUS       DAEQCW010000189         4133 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.190, whole genome shotgun sequence.
ACCESSION   DAEQCW010000189 DAEQCW010000000
VERSION     DAEQCW010000189.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4133)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4133)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4133
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.190"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            166..1092
                     /locus_tag="KRO40_003487"
     CDS             166..1092
                     /locus_tag="KRO40_003487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBH2094280.1"
                     /translation="MSKENKNVRIAVVQASPVIMDLEKTVEKALGLIKEAGRKGANIV
                     VFPEAFIPAYPRGLSFGFVVGSRTMEGREDWKRYYDNSVPVPSATTDLLGKAAQEAGV
                     YLSMGITERDGNDINCTLYCTNLFFSPEGKLIGKHRKLKPTGTERCIWGEGDGSTLTV
                     VDTPYGKMGSLICWENYMPLARTALYAKGVKLYIAPTADSREEWQATMKHIALEGRCF
                     VIGCNQYVEKNMYPTDLNYYKELDAEPEIMCPGGSCIVDPFGKYVAGPIFNKEEMLIA
                     DLDLEKIVLSRLDFDSEGHYSRPDVFELIVHE"
     gene            complement(1212..2210)
                     /locus_tag="KRO40_003488"
     CDS             complement(1212..2210)
                     /locus_tag="KRO40_003488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhdH/YhfP family quinone oxidoreductase"
                     /protein_id="HBH2094281.1"
                     /translation="MNKKFKSLYITEEEGNFRRNIVEREVDTLPEGEVLIKVKYSSLN
                     YKDALSANGNKGVTRKYPHTPGIDASGIVESSSCDDFKIGEEVLVTGYDLGMNTSGGF
                     SEYIRVPSSWVVKLPKNLSLKEAMDYGTAGFTAALSVYKFIDSVDKNMGDVLVTGGTG
                     GVAVIATKILIKLGYSVVVSTGKLEEQKEVLLNLGVKDVIHRSEVDDNSGRPLLRPRW
                     AGVIDTVGGNTLATAIKTTNYCGAVTTCGNAGGVDFTSSVYPFILKGITLYGIDSVDC
                     PMNLRLKIWDLLSNEWKLDDLDDMVNVVSLEELNDSIDSIMAGKHVGRTVVDLEKI"
     gene            2314..2751
                     /locus_tag="KRO40_003489"
     CDS             2314..2751
                     /locus_tag="KRO40_003489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2094282.1"
                     /translation="MEDKYIVHFISKTKASMIKFIENKLSKNGLGELIPTHGNILTAL
                     YENNGILTMKEIAAKIGKDKSTVTVLVNKLINLGYLERQKCTNDKRITYIKLTKKALL
                     IEDTFNSISTQVKETAYHNITENEKQEFLRILKKINDNFKNAD"
     gene            2837..3424
                     /locus_tag="KRO40_003490"
     CDS             2837..3424
                     /locus_tag="KRO40_003490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBH2094283.1"
                     /translation="MNLKDSKTKENLLRAFAGESQARNRYNISASVAKKEGLYIIESL
                     FNYTADQEKSHAKQFFSKLKEFAGENISISGAYPVDLYDKTAQHLKAAQHNELQEWDD
                     VYKNFGKTAREEGFESIAKLFENIAEIEKVHGDRFGRYATDLEEGTLFRRNEDIQWIC
                     THCGHIHIGKEAPKACPVCLHPQGYFLDFKNSLFE"
     gene            complement(3724..>4133)
                     /locus_tag="KRO40_003491"
     CDS             complement(3724..>4133)
                     /locus_tag="KRO40_003491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DUF4004 family protein"
                     /protein_id="HBH2094284.1"
                     /translation="IANMFMKKDINKEFDIDFILSKEVICNYTKEIFQNLYKKEQSIG
                     KKELLILSIIEKFLVKSIITFEELKLIVNIIEENFTSIYNESGKIYLFRKFGVPFVVG
                     CLDYKKVKFEKDVVKIIEVDLTKEINDISIKLS"
BASE COUNT         1532 a          622 c          548 g         1431 t
ORIGIN      
        1 ctaaactcaa ttatatctgt acaattgtaa ttttttaaat catgatgtat tattttaaat
       61 atacagttac attattattc acaatataag tatcttagtt ctcaaataac atctcatgta
      121 atctattcaa tgcaaaaaat ttaaatattt tttaggaggt tttttatgag caaggaaaat
      181 aaaaatgtaa gaattgctgt tgtccaggcg tcaccagtca taatggattt agaaaaaact
      241 gttgaaaaag cattaggatt aattaaagaa gctggtagaa aaggggcaaa tatcgtagtt
      301 ttccctgaag cattcatacc tgcatatcca agaggtcttt catttggatt tgttgttgga
      361 agtagaacaa tggaaggtag agaagattgg aaaagatact atgataattc tgtaccagtt
      421 cctagtgcta caacagattt attaggaaaa gcagcacaag aagcaggagt atatctatca
      481 atgggtataa cagaaagaga tggtaatgat ataaattgta ccctttattg cacaaactta
      541 tttttctctc cagaaggtaa gctaattggt aaacacagaa aacttaaacc tacaggaaca
      601 gaaagatgta tttggggaga aggagatgga agtactctta cagtagttga tactccatat
      661 ggaaaaatgg gttcgttgat ttgttgggaa aattatatgc cattagctag aacagctctt
      721 tatgctaagg gtgtaaaact ttacatagcc cctactgcag attcaagaga agagtggcaa
      781 gcaactatga agcatattgc tttagaagga agatgttttg taattggatg caatcaatat
      841 gttgaaaaaa atatgtatcc aactgacctt aactactata aagagctaga tgcagaacca
      901 gaaattatgt gtccaggagg aagttgtata gttgaccctt ttggaaaata tgtagcaggt
      961 cctattttca ataaagaaga aatgctaata gctgatttag acctagaaaa aatagtactt
     1021 agtagactag attttgattc agaaggtcac tattcaagac cagatgtatt tgaattaatt
     1081 gttcatgaat aatcttttta cacaaacatc tacataaatc tttttacata aaaaaatgag
     1141 atactcataa gtaaatttca agtatctcat ttttgcttaa aacctataat cctaattata
     1201 aatttattca cctatatttt ttctaaatca actactgttc ttccaacatg ttttcctgcc
     1261 attattgaat ctatactatc atttaactct tccaatgata ctacatttac catatcatct
     1321 aaatcatcta atttccattc atttgataat aaatcccata tttttaatct taagttcatt
     1381 gggcaatcca cagaatctat accatataaa gtaattccct ttaagataaa tggatatact
     1441 gaacttgtaa aatcaactcc tcctgcatta ccacaagttg ttactgctcc acaataatta
     1501 gttgtcttta ttgctgttgc tagagtattt cctcctactg tatctattac tccagcccat
     1561 cttggtctaa gcagaggtct tcctgagtta tcatccactt ctgacctatg tataacatct
     1621 ttaacaccta agtttagtaa tacttctttt tgttcttcta attttcctgt tgaaactaca
     1681 actgaataac ctaatttaat caatatttta gttgcaatta cagcaactcc tccagtacca
     1741 ccagtgacta atacatctcc catattcttg tctacagaat ctataaattt atacacagat
     1801 aaagctgctg taaaccctgc tgtaccataa tccattgctt cttttagtga aagattttta
     1861 ggaagtttaa ctacccaact agaaggaact cttatgtatt ctgaaaaacc accagaagta
     1921 ttcattccca agtcataacc tgttactaaa acttcttctc caattttaaa atcatcacaa
     1981 ctactagatt ctactatacc agatgcatca attcctggtg tatgaggata ctttctcgta
     2041 acacccttat taccatttgc agaaagtgca tccttgtaat ttaaagaaga atattttact
     2101 tttattaaaa cttcgccttc tggcaatgta tccacttctc tttcaactat atttcttcta
     2161 aaatttcctt cttcttctgt aatatatagt gatttaaatt ttttattcat aaatttcctc
     2221 ccaatacatt tagttttatg ttaaactaat tatagtttat aaatagtttt atgtcaaact
     2281 aatttaaata gattaaagat tggagaataa tttatggaag ataaatatat tgtacatttc
     2341 ataagtaaaa caaaggctag tatgattaaa ttcattgaaa ataaactcag taaaaatggt
     2401 ttaggtgagt taatacctac tcatggaaat attttaactg cactttatga aaataatgga
     2461 atacttacaa tgaaagaaat tgcagctaaa ataggaaaag ataaatccac tgttacagtg
     2521 ttggttaata aacttataaa cctaggatat ttagaaagac aaaaatgtac aaatgacaaa
     2581 cgtatcacgt atataaagct tacaaaaaag gcactgctta tagaagatac ttttaatagc
     2641 atctcaacac aagttaaaga gacggcatac cataatatta cagaaaatga aaaacaagaa
     2701 tttcttagaa ttttaaaaaa aattaatgat aattttaaaa atgctgacta aattgagcat
     2761 aattatatct cctattggaa taataaataa aaagaatcaa atattgtaaa aatttattgt
     2821 gatagagagg tagaatatga atttaaaaga tagtaaaact aaagaaaatt tattaagagc
     2881 ttttgcaggt gagagtcaag ctagaaatag atacaatatt tctgcatctg tagcaaaaaa
     2941 agaaggatta tatataatag agtctttatt taattacact gctgaccaag aaaaatcaca
     3001 tgcaaaacaa ttcttttcta aattaaaaga atttgctggt gaaaatataa gtatatcagg
     3061 agcataccct gtagatttat atgacaagac agcacaacac cttaaagctg cacaacataa
     3121 tgagcttcaa gagtgggatg atgtatataa aaactttgga aaaacagcac gtgaagaagg
     3181 atttgaatct atagctaagt tatttgaaaa tatagctgaa atagaaaaag ttcatggtga
     3241 tagatttggt agatatgcta ctgatttaga agaaggtact ttattcagaa gaaatgaaga
     3301 tatacaatgg atatgtacac attgtggcca tatacatata ggtaaagaag ctcctaaagc
     3361 ttgtcctgta tgtcttcatc cacaaggata tttcttagat tttaaaaact cattatttga
     3421 ataaactaag gtaatcattg tatttaaaca atttactata tttatatcaa gtatttttat
     3481 aaatactgta ttatcttaat aacaataaaa tgaaccattg atattactat aagtagaaaa
     3541 tgtagtttaa atacaattta tagtagttca tcatggttca ttttattgtt tactaatccc
     3601 tataacttac ttaaatctat ctttaacttt tacatactca cataaatcct catctctaaa
     3661 ctaaatattt aaataaagtg tattttaagt agattattat aatacattat ataagataat
     3721 acactatgat aactttatac ttatatcatt tatttctttt gtcaagtcaa cctcaataat
     3781 cttaactaca tctttttcaa actttacttt tttataatcc agacatccta ctacgaatgg
     3841 aactccaaac tttctaaaca aataaatctt tccactttca ttgtatattg atgtaaaatt
     3901 ttcttctatt atattcacta tcaattttaa ctcttcaaaa gttattatag atttaactaa
     3961 aaacttctct attatgctca atataagcag ttctttttta cctatgcttt gttctttttt
     4021 atataaattt tgaaatattt ctttggtata attacatata acttctttac tgagaataaa
     4081 atcaatgtca aattctttat taatatcctt tttcataaac atatttgcaa tat
//
LOCUS       DAEQCW010000190         4115 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.191, whole genome shotgun sequence.
ACCESSION   DAEQCW010000190 DAEQCW010000000
VERSION     DAEQCW010000190.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4115)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4115)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4115
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.191"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            359..1633
                     /locus_tag="KRO40_003492"
     CDS             359..1633
                     /locus_tag="KRO40_003492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBH2094285.1"
                     /translation="MQFMDVSKYIEGANLKVKTKSGETVKRIYFNNSATPLVLKNVVD
                     NLNCEIPLLTYINAPGIISEKNTLKYENVRSTILKLIDGDEEKDSVIYVKNATEGINF
                     LAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
                     GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEH
                     IDFVVFSAHKCYSPLNGGALVGPKKFFEKFNPVLYGSGSTKFVNDNKILYANVPQRFE
                     AGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYAKEEMSKIPNIIIYGDKSNNV
                     IIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGISPKEAYVRFMRE
                     NPVGLVRISLGMYNTFDEVDSFIHAIKTLAFK"
     gene            complement(1840..2157)
                     /gene="trxA"
                     /locus_tag="KRO40_003493"
     CDS             complement(1840..2157)
                     /gene="trxA"
                     /locus_tag="KRO40_003493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBH2094286.1"
                     /translation="MVKIVNNNEFINEVENKDGLVVVDFFATWCGPCKMLSPIYEALG
                     NEMVEKANFLKVDIDQSIELAQKFEVSTVPTMLIFKDGKPVDRLIGFMPKENLKNKIE
                     SYM"
     gene            2424..3176
                     /locus_tag="KRO40_003494"
     CDS             2424..3176
                     /locus_tag="KRO40_003494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrmB family transcriptional regulator"
                     /protein_id="HBH2094287.1"
                     /translation="MDNIINELQNIGFTKYESQIYISLLKESPLTGYEISKLSGVPQS
                     KVYENITKLLNNNIIINVGTDPIKYIPINPNELLKNKKKEFDNSMDNLKNSLQILNKS
                     KSVEYVLNIKGDKNILKKAIEMIKNAKQEIIISCPYEEILELKKELLIAYKKNINIEI
                     LLLENKSLKGLDNIHIHGGNKTTLENKMLYKGIILIVDNDEILTGNLSEGSEAISIWT
                     KNSNILYIGVQYIKHEIYISEQIKGGYKNEQN"
     gene            3163..4044
                     /locus_tag="KRO40_003495"
     CDS             3163..4044
                     /locus_tag="KRO40_003495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBH2094288.1"
                     /translation="MNKIKIKQVDAFTTIPFGGNPAGVVTDTSNISDEIKQNVAKEMN
                     LSETAFVSESNIADFKVQFFTPGLEVDLCGHATIGTFHALLEEGKLNTNKSIFYQETK
                     AGVLSVELKKINNENIFMMEQNTPEFENLDNCRKELAQMIGVHEDRLLEYPIIKVNTG
                     LWWLVFGLKSLDDLKNISPDLNKIKKFSGDNNIIGITPFCIETIDKKCDYHLRSIAPY
                     VGVTEDPVCGTGNACVSSYIVHHNILDKTSFIGEQGNFINRPGKVYVNITRENNNITS
                     VKIGGSAYTVLSGEIMY"
BASE COUNT         1615 a          535 c          567 g         1398 t
ORIGIN      
        1 gttctaatca atttctttac tatttttaca actttattag tcatattcat aattatttct
       61 aattagtgtt taacatttta tgtaaaattt ataaaaaaat gtatataaat taaaataagt
      121 gactatacta aaaatatgat acggataaac aataagttca acctatctcc cccaaaatca
      181 agtgagctac agtttccccc aactgtagct cattttcgtg taatttaata aacatctcaa
      241 caagaattaa ttaacaaaac cccttataaa aacataacat atattaaaca agctcttgat
      301 taaaacttga gcttttttaa taaaaaacag aatagtttat tagataaggg gtttttttat
      361 gcaattcatg gatgtatcta aatacattga aggtgcaaac cttaaagtta aaactaaaag
      421 tggtgaaact gttaaaagaa tatattttaa caactctgcc actccattag ttttaaaaaa
      481 cgtagtggat aacttaaact gtgagattcc tttgcttact tatattaatg ctccaggaat
      541 aatctcagaa aaaaatactt taaaatatga aaatgtacgc tctactatcc tcaaacttat
      601 tgatggagac gaagaaaagg attctgttat ttatgtcaaa aatgctacag aaggaataaa
      661 cttcttagca aaatttttta aagatgaaaa tccagataaa tttgttatta ccacagcaat
      721 ggagcatatg gctaattacc tgccttttaa agttaatttt cctacaaaag ttgttggaat
      781 tacagaaaaa ggagaacttg atttatgtca attagagaat atacttaaaa attatgctgg
      841 taatgtatct ctcgttacag ttacaggagc tagtaatgtc acaggtataa ccactcctat
      901 atatgaaata gcaagaatag ctcataagta tggtgcaaag atattggtgg atattgtgca
      961 agtaattcag cataaacctt tttcaatgat gccacatgaa tgtgatgagc atatagattt
     1021 tgttgttttt agtgctcata aatgttattc tccactaaat ggaggagctc tggtaggacc
     1081 taaaaaattc tttgaaaaat ttaatcctgt actatatggc tcaggttcta ccaaatttgt
     1141 aaatgataac aaaatactat atgcaaacgt accccaacgt tttgaagcag gatacccaga
     1201 gtattttgga actcttgcaa tgggaaaagc actgaacact ttaaataaaa ttggtctaaa
     1261 cagaatttca aaatacgaaa gagaattatt tttatatgct aaagaagaaa tgagtaaaat
     1321 acctaatata ataatatatg gagataaatc aaataatgta attatcccaa atatatcttt
     1381 taatataagt aatatgtatt acaaagatgt agcaaaatat ttagttgata actttggaat
     1441 agaaactgga gctggagtag taggtgcaga tatttatgta caaaaattat taggtataag
     1501 tccaaaagaa gcatatgtca gatttatgag ggaaaatcct gtaggtcttg ttaggataag
     1561 cttaggaatg tacaatactt ttgatgaggt ggatagcttt atacatgcta ttaaaacttt
     1621 ggcttttaaa taagtttttt ctattctttt ttatcaataa atagagagta gttttgtttt
     1681 cacaaaaaag caaattatat caacagtcaa tttcattagc aattagacac tcatttgtaa
     1741 ctatacaaac tattttacac tatacaaaca aaaaactcat tacaatgagt ttttttgttt
     1801 atatatgaga tttattttaa ttacttcaat ttactttaat tacatatatg attcaatttt
     1861 gttttttaaa ttctccttag gcataaaacc tattaatcta tctacaggtt ttccatcctt
     1921 aaatattagc atagttggta ctgtagatac ttcaaatttc tgagctaatt ctatactttg
     1981 gtctatgtcc accttcaaga agtttgcttt ttcaaccatc tcatttccta aagcttcata
     2041 tattggtgat agcatcttac aaggtccaca ccaagtcgca aagaaatcta caactactaa
     2101 accatcttta ttttctactt catttataaa ttcattatta tttactattt ttaccataat
     2161 atacatctcc tttattatct tcttgatatt aatatactac gacctatata acagttcaat
     2221 taggcacttt tttgtaaccg cctattttta atagatttaa tattatgata aatagattta
     2281 taagattaaa tatttataag actaaatatt tctaatatat tttatttttt tcttaatata
     2341 gttgacattt tttcccttaa attataaaat caaattaata actacatagg tagttactaa
     2401 tcttttatca aaggagtttc tatatggata atattattaa tgaattacaa aatataggat
     2461 ttactaaata cgaatctcaa atatacatat cattattaaa ggaaagccct ttaacaggat
     2521 atgaaataag taaattatca ggtgtaccac aatcaaaagt ctatgaaaat ataacaaagc
     2581 tattaaacaa taatataatt atcaatgttg gaactgaccc tattaagtac ataccaataa
     2641 accctaatga attattaaaa aataagaaaa aagaatttga caattctatg gataatctaa
     2701 agaatagctt acagatatta aataaaagta aaagtgtaga atacgtatta aacataaaag
     2761 gagataaaaa tatattaaaa aaagcaatag aaatgataaa aaatgcaaaa caagaaatta
     2821 taatttcttg cccttatgaa gaaattcttg aattaaaaaa agaactccta attgcttaca
     2881 aaaaaaatat taatattgaa atactacttt tagaaaacaa aagtctgaaa ggtcttgata
     2941 atattcatat tcatggaggt aataaaacta cacttgaaaa taaaatgctt tacaaaggaa
     3001 ttattttgat tgtagataat gatgaaatat tgacaggaaa cttatcagaa ggcagtgagg
     3061 ccatttcaat ttggacaaaa aactctaaca ttttatatat tggagttcaa tacataaaac
     3121 atgaaattta tatttcagaa caaataaaag gaggttataa aaatgaacaa aattaagatt
     3181 aaacaagttg atgcttttac aactatacct tttggtggaa atcctgctgg tgtcgttact
     3241 gatacctcta acatttctga tgaaattaag cagaatgtgg ctaaagaaat gaatttatca
     3301 gaaactgcat ttgtttcaga gtcaaatatt gcagatttta aagtacaatt tttcacacca
     3361 ggtttagaag ttgatttatg tggtcatgca acaataggta ctttccatgc acttttggaa
     3421 gaagggaagc ttaatactaa taaaagtata ttttatcaag aaacaaaagc tggtgtatta
     3481 tctgtagagc ttaagaaaat aaataatgaa aatatattta tgatggaaca gaatacacct
     3541 gaatttgaaa atttagataa ttgcagaaaa gaacttgcac aaatgatagg tgtgcatgaa
     3601 gatagacttc ttgaatatcc tattataaag gtaaatactg gactttggtg gcttgtattt
     3661 ggtctaaaat ctttagatga tttaaaaaat atctctccag atttaaataa aatcaaaaaa
     3721 tttagtggtg ataataatat aattggtata actccatttt gtatagaaac tatagataaa
     3781 aagtgtgact accatttaag atctatagca ccatatgttg gagttacaga agaccctgta
     3841 tgtggaactg ggaacgcttg cgtatcatct tatatagtac atcacaatat tttagataaa
     3901 actagtttta ttggtgagca aggtaacttt ataaacagac ctggaaaggt atatgtaaat
     3961 ataactagag aaaacaataa cataacttct gtaaaaattg gaggaagtgc ttatactgtc
     4021 ttaagtggtg aaattatgta ttaatcccat acctaataaa aacaaataaa aatactagct
     4081 aactaaagct agtattttta tttgttattt ttatt
//
LOCUS       DAEQCW010000191         4016 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.192, whole genome shotgun sequence.
ACCESSION   DAEQCW010000191 DAEQCW010000000
VERSION     DAEQCW010000191.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4016)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.192"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            170..1123
                     /locus_tag="KRO40_003496"
     CDS             170..1123
                     /locus_tag="KRO40_003496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBH2094289.1"
                     /translation="MKKRYLVIGIIILSYFSLFIGAEDINIMHIFAKNQHKLMIFIMS
                     RIPRLISILIAGVGMSIAGLIMQQISKNKFVSPTTGATIDAAQFGIVICMLLVPTASI
                     FTKTIIAFVFSLVGTFTFMKIIGKLQFKNIIFVPLVGIMFGNIIGSMTDFIAYKYDLS
                     QNVSSWMQGDFSMILKGNYEILYITIPLIILAYIYANKFTVVGMGMDFATNLGLSYKR
                     IVNIGLIIVALVTVCVVVTAGNIPFIGLIVPNIVSLYMGDNIRASIWYTGLLGAIFVL
                     ICDIFGRIIIYPYEISIGLTVGVIGSILFLYLILRRNVNEA"
     gene            1113..2069
                     /locus_tag="KRO40_003497"
     CDS             1113..2069
                     /locus_tag="KRO40_003497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBH2094290.1"
                     /translation="MKLSLNQKIYFVSILLFISMALFIIYGIDMNHLEYALSQRIPKI
                     FAMVLGGGCIAFTTVVFQTITNNQILTPSVLGLDSLYVMIQTIIVFIFGSSSSLIINE
                     NYNFIINVAMMIGASLLLYKTLFEKNKNNIFFLILVGMIFGTLFKSATTFIQVMIDPN
                     EFLALQTSIMASLNNINTNVLLIAFIIIIAIIPFIYDEIKYLDVLSLGKEQAINLGVD
                     FDKAVKKMIILIAILVSISTALIGPMTFLGLLLANITREIFKTYKHTYLISGSMLIGM
                     ITLIIGQFFIQHVFKFDTTLSVVINFIGGIYFIQLLLKGANR"
     gene            2066..2821
                     /locus_tag="KRO40_003498"
     CDS             2066..2821
                     /locus_tag="KRO40_003498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2094291.1"
                     /translation="MIEIKNIFKRYKNKNVVDDVSFSIEKGKITSFIGPNGAGKSTVL
                     SIVTRLIGGDGGEVIIEGKSLTNYSNKELAKKIAILKQSNNITLKLTIRELVGFGRFP
                     YSEGNLTKEDENYIDEAIEYMKLTDIQHKYLDELSGGQRQRAYIAMVIAQDTEYILLD
                     EPLNNLDMNHSVQMMKVLRGLCDELDKTIVLVMHDINFASCYSDNIVALKNGKVEKVG
                     RTDEIVNEKVLEDIYEMNFNIKNINGNRICIYF"
     gene            2913..3878
                     /locus_tag="KRO40_003499"
     CDS             2913..3878
                     /locus_tag="KRO40_003499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2094292.1"
                     /translation="MNKKAAIVAAVAIIGLVTVFALGGSKKNESKTSENSNNTMKITH
                     NLGETDVKLNPKKVVVFDYSALDTMDALGVAETLVGLPKASLPASLEKYKDDKYADLG
                     GLKEPDLEGIKSANPDLIIINGRQEDFYEQLSKIAPTISTSKDDKKYLESVKNNIDKI
                     AKIFGVEEKANQEFSKIEKKIETLNKKVTDKNLNALTIMVNEGNLSVFGEESRFSILY
                     NSFGFENKDKNIKESSHGQNITFEYIAKQNPEVMFVIDRGIATGSDVKESSTAKSVLN
                     NDIIKSMDAYKNDNIIYLDSPTWYVNDGGLTSLNKMIDDASKAVN"
BASE COUNT         1619 a          379 c          673 g         1345 t
ORIGIN      
        1 taatttatta aattttaatg ttactagaag tttcaattct agtaacattt tttatgttaa
       61 aaacagatat agatatgtat tgacaatgat aattattatt gataaactat aaaagtgaaa
      121 atgataataa ttttcatttt aattaataaa agatttttaa ggagggagaa tgaagaaaag
      181 gtatttagtc ataggaataa taattttgtc ttatttttct ttatttatag gagctgaaga
      241 tataaatata atgcatatat ttgccaaaaa tcagcataaa cttatgatat ttatcatgag
      301 tagaatacca agattaataa gtatattgat tgctggtgta ggaatgagca tagcaggtct
      361 tataatgcaa cagataagta agaataaatt tgtatcacct acaacaggtg ctacaataga
      421 tgcagcacaa tttgggatag taatatgtat gcttttagta ccaactgcct ctatttttac
      481 aaagacaata atagcatttg tattttctct tgtagggact tttacgttta tgaaaataat
      541 agggaagtta caatttaaaa atataatctt tgtaccatta gtaggtataa tgtttggaaa
      601 tataataggg tctatgacgg attttatcgc gtataaatac gatttgagtc aaaatgttag
      661 ttcttggatg caaggtgact tttctatgat acttaaagga aattatgaga tattatatat
      721 cacaataccc cttataatat tagcatatat ttatgcaaat aaatttactg ttgttggtat
      781 gggtatggat tttgcgacaa acttaggtct tagttacaaa agaattgtca atataggtct
      841 gataatagta gcacttgtta cagtatgtgt agtcgttaca gctggtaata tcccttttat
      901 aggtctaata gttccaaata tcgtatcctt gtacatgggt gataatataa gagcaagcat
      961 atggtatact ggtttacttg gagcgatatt tgtacttata tgtgatattt ttggaagaat
     1021 tattatttat ccatatgaaa tatctatagg gcttacagtt ggagttatag gaagtatact
     1081 attcctttat ttaatattaa ggaggaatgt gaatgaagct tagtctcaat caaaaaattt
     1141 actttgtaag tatattacta ttcatatcaa tggcactttt tataatttat ggaatagaca
     1201 tgaatcattt agaatatgca ttatcacaaa gaataccaaa aatatttgct atggtattag
     1261 gtggaggatg tatagcattt actactgtag tgtttcaaac aattacaaac aatcaaatat
     1321 taacaccaag tgtactaggt ttagattcat tgtatgtaat gattcaaact ataatagtat
     1381 tcatatttgg ttcaagcagt agtctgatta taaatgaaaa ttataatttt attattaatg
     1441 tagctatgat gattggagct tcattgttat tatataagac gttatttgaa aaaaataaaa
     1501 ataatatttt ctttttaatc ctagtaggaa tgatatttgg aaccttattt aaaagtgcaa
     1561 caacatttat tcaggtaatg atagacccta atgaattttt agctttacaa actagtataa
     1621 tggcaagttt aaacaatata aacactaatg tattgttaat agcatttata ataattattg
     1681 ccataatacc ttttatatat gatgaaataa agtatttaga tgtattgtcg ttaggtaaag
     1741 aacaagcaat taatttaggt gtagattttg ataaagcagt taaaaaaatg ataatattaa
     1801 tagcaatttt agtctcaata tcaacagcac ttattggacc tatgacattt ttaggacttt
     1861 tacttgctaa tataacaaga gaaattttta aaacatataa gcatacatac ttgatttcgg
     1921 gttctatgtt gatagggatg attacattga taataggtca attttttata caacatgtat
     1981 ttaagtttga tacaacttta agtgtagtaa taaattttat aggaggaatt tattttattc
     2041 aattactatt aaagggggca aatagatgat agagataaaa aatatattta aaagatataa
     2101 gaataaaaat gttgtagatg atgtctcttt tagtatagaa aagggaaaga taacatcttt
     2161 tataggacca aatggagctg gaaaaagtac agtactatca atagttacaa gacttatagg
     2221 aggtgatggt ggagaagtaa taatagaagg aaaaagcttg actaattata gcaataaaga
     2281 attagcaaaa aaaatagcta ttcttaaaca atctaacaat ataactttaa agcttacaat
     2341 aagagaatta gttggatttg gaagatttcc atatagtgaa ggtaatctaa ctaaagagga
     2401 tgaaaattat attgatgaag caatagaata tatgaagttg actgatatac aacataagta
     2461 tttagatgaa ttgagtggag gtcaaagaca aagagcttat atagcaatgg taatagctca
     2521 agatacagag tacatattac ttgatgaacc actgaacaat ttggatatga accattccgt
     2581 acagatgatg aaggtactta gaggtctttg tgatgaatta gataagacta tagtattagt
     2641 aatgcatgat ataaattttg catcatgtta ttcagataat atagttgcat taaaaaatgg
     2701 aaaagttgaa aaagtaggtc gtacagatga gatagtaaat gaaaaagttt tagaagatat
     2761 ttatgagatg aattttaaca ttaagaatat aaatggaaat cgaatctgta tttattttta
     2821 aaatattgta tatgaaaata aacttgctat atgatttttt ataaagtttt taaattaaaa
     2881 taaagattaa taggagagag gaaaatattg atatgaataa aaaagcagca atagtagcag
     2941 cagtagctat tataggatta gtgacagtgt ttgcattagg tggaagtaaa aagaatgaat
     3001 caaaaacatc agaaaattca aataatacta tgaagataac tcataacttg ggagaaacag
     3061 atgtaaaatt aaatcctaaa aaagtagtgg tatttgatta ttcggcttta gatacaatgg
     3121 atgcattagg tgtagctgag actttagtag gacttccaaa agcgagttta ccagcatcct
     3181 tagaaaaata taaggatgac aagtatgcag atttaggagg attaaaagaa ccagatttag
     3241 aaggtataaa gtcggcaaat ccagatttaa ttataataaa tggaagacaa gaagattttt
     3301 atgagcaatt gtcaaaaata gcaccaacaa taagtacaag taaagatgat aagaagtact
     3361 tagaatctgt taaaaataat atagacaaaa tagcaaaaat atttggagta gaagaaaaag
     3421 caaatcaaga atttagtaaa attgaaaaga aaatagaaac tttgaataaa aaagtaacag
     3481 ataaaaattt aaatgcttta actataatgg taaatgaagg taatttaagt gtatttggtg
     3541 aagaatcaag atttagtata ttatacaata gttttggatt tgaaaataaa gataaaaata
     3601 taaaagaatc aagtcatgga caaaatatta cttttgaata tatagctaaa caaaatccag
     3661 aagttatgtt cgttatagat agaggaatag ctactggcag tgatgtaaaa gaaagctcaa
     3721 ctgcaaaatc tgttttgaac aatgatataa taaaatctat ggatgcatat aagaatgata
     3781 atataatata tttagattca ccaacatggt atgtaaatga tggtggtcta acatctttaa
     3841 ataaaatgat agatgatgct tcaaaagcgg taaattaata atccgatata accaaaatgt
     3901 attttttata aaatgattat caaataaact aggagttttt aagaactcct agtttatttt
     3961 ttgcataaaa aagatatagt ttaaacaata atattatcta taataagata aatcta
//
LOCUS       DAEQCW010000192         3895 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.193, whole genome shotgun sequence.
ACCESSION   DAEQCW010000192 DAEQCW010000000
VERSION     DAEQCW010000192.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3895)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.193"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            186..860
                     /gene="fsa"
                     /locus_tag="KRO40_003500"
     CDS             186..860
                     /gene="fsa"
                     /locus_tag="KRO40_003500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBH2094293.1"
                     /translation="MQLILDTGNVEEIKELCTCLPIDGVTTNPSIVSKEKKNFKQLIN
                     EIGEIIGEDMPIHAQVLSTKYEEILEEALYISSLRKNIYVKIPVTQDGLRAIKDLHRK
                     GIKITATAIFTAHQGFLAAKAGANYIAPYVNRLDNISGDGVAMVSELIKIIDTYKMDT
                     KVLAASFKNAQQVIELMQHGVHSVTVPYDICKSMMNHPLTDWSVDKFIEDWENTFGKG
                     SKTNNI"
     gene            complement(982..2376)
                     /locus_tag="KRO40_003501"
     CDS             complement(982..2376)
                     /locus_tag="KRO40_003501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HBH2094294.1"
                     /translation="MGIILKPKQFYMTVIATIILYFSLNYSFNIKFSICLSFLTILIW
                     AVDSVEKTFVALFFVILAFIFNIAPIKVILQFLFTENFYIIILAYIITNAVTKTGVAK
                     IISEKLILNTVNTPKKMILLSYILGILLIFFIPQPFPRVILVSAFYKEFLKEQQITED
                     SKSILLFSIFTASTFTSMFFVNGDTLLNYVVLELGNCNINWGQWAFYMSVPTIITCFI
                     TYFLFIFVFKKELHSIKFISNENLEGNKLHFSYSNLKKEFNLLNKEQKHVFLCLGIMF
                     FMFLTQFIHNINTLIIMSICVLLLLLRKIVGFSTLKEINWKVLIFFIAAFSIGGVLKY
                     SGVVDIMGNYLIKFIPNSSEIISILFLITLTIILNICLGSAVTTSSVVIPLLGSLHIL
                     KENSVTLCLFVYIIVSIQYILPFHHATIMVGHGENLYNSKVIFKYGLTLIPLTYFIII
                     CITFPWWKFIGLEI"
     gene            complement(2454..3800)
                     /locus_tag="KRO40_003502"
     CDS             complement(2454..3800)
                     /locus_tag="KRO40_003502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBH2094295.1"
                     /translation="MKDLTTGHEGKSIFFFAMPMLIGSLFQQLYNTADSIIVGRFIGK
                     EAMAAVSGANPIMFLLVAALMGVSLGFSILVSQFYGSGDLKKVKATIDTTYILLFIGS
                     ILISILGIVFGGPMLKLMNTPESVFAQSKLYLTIIFSGILFSAGYNSVSAILRGLGDS
                     VTPLYFLIIATILNIVLDLTFIVVLRMGVEGVALATIMAQAVSFIISIIYLNKKHEVL
                     KFKIKGIVYDNKIFKDGLRLGLPSGVQQMLFSIGNMALQFLVNSYGTSAMAAFGAGLR
                     IENFISLPIMNLGSAVSTFVAQNIGAGENERVKKGIRESIKMTLVLAVTVIALILLFR
                     ENLIALFNTDKDVIKIGSSYLFIIGPFFLFIGTSFVLSSAMKGAGDSMFALISSIVSL
                     WLGRLPASYMLSKFFGTDGIWMGIPFGWTLGLIVTVIYYKKGHWKTKAIVNHRINE"
BASE COUNT         1557 a          537 c          533 g         1268 t
ORIGIN      
        1 taatttaata taaaaagtat gttttttcta actatatatt tagaatttag taaataaaaa
       61 aattataaaa ctaagaagga aaagtaaaac aataataaaa aataaaaaac aataagcaaa
      121 atgttgaaaa taataccaaa tcaatatata ataagaataa agaaagatta aagggggata
      181 ttttaatgca actaatctta gatacaggta atgtggagga gattaaggag ttatgtactt
      241 gtttaccaat agatggtgta actacaaatc caagtattgt ttcaaaagaa aaaaagaatt
      301 ttaagcaact tataaatgaa attggtgaga ttataggtga ggatatgcct atacatgctc
      361 aagtgttaag tacaaagtat gaagaaatat tagaagaagc attatatata agtagtttga
      421 gaaaaaatat atatgtaaaa atacctgtaa cacaagatgg tttaagagct ataaaagacc
      481 ttcacagaaa aggtataaaa ataactgcta ctgcaatatt cactgctcat caaggttttt
      541 tagctgcaaa ggctggagca aattatattg caccttatgt aaataggctt gataatatat
      601 ctggtgatgg agtagctatg gtttcagaac ttataaaaat aatagatact tataaaatgg
      661 atacaaaagt acttgcagcc agttttaaaa atgcacaaca agttatagaa ttaatgcaac
      721 atggggtgca tagtgttaca gtaccatatg atatttgtaa atctatgatg aatcatccat
      781 taactgattg gagtgtagat aagtttatag aggattggga gaatactttt ggaaaaggaa
      841 gtaaaacaaa taatatttag tattatggta aaagagtagt tttgtccaat ttcacaagaa
      901 cttatataaa aagatgaaaa tatgaatttt ctttttaata atttcgttat tatcttaagt
      961 taattcatat tttcatcttt tttagatttc tagtcctata aatttccacc aagggaatgt
     1021 tatacatatt attataaagt aggttaaagg aatcaaagtt aaaccgtatt tgaaaataac
     1081 cttgctatta tacagatttt caccatgacc aaccattatt gtagcatgat gaaatggtaa
     1141 tatgtactgt atgcttacta taatgtagac aaatagacat aaagtaacac tattttcctt
     1201 tagtatatgt aaacttccaa gtaacggtat tactacagat gatgtagtga cagcacttcc
     1261 aagacatata ttcaagatta ttgtgagagt tatcaaaaac aatattgaaa taatttctga
     1321 agagtttggt ataaacttta tcaaataatt tcccattata tctacaactc cagagtactt
     1381 taacactcct ccaattgaaa atgctgctat aaaaaaaata aggaccttcc aatttatttc
     1441 ttttaaagta ctaaatccaa ctatttttct tagtaataaa agaagtacac aaattgacat
     1501 tataattaat gtgtttatgt tatgtatgaa ctgagttaaa aacataaaaa acattattcc
     1561 taggcataaa aatacgtgtt tttgctcttt gtttagcaaa ttaaattctt tttttaaatt
     1621 agaatatgaa aaatgaagtt tattaccctc aagattttca ttagaaataa attttattga
     1681 atgcaattct tttttaaaga caaagataaa taaaaaataa gttataaaac aagtaattat
     1741 agttggaaca gacatataaa aagcccattg accccaattt atattacaat ttccaagttc
     1801 tagtacaaca taatttagaa gagtgtctcc atttacaaaa aacattgatg taaaggtaga
     1861 tgctgtaaat atactaaata aaagtataga ttttgaatct tcagttatct gttgttcttt
     1921 taaaaactcc ttgtaaaaag cagatacaag aataaccctt ggaaatggtt gtgggataaa
     1981 aaatattaaa agtataccta aaatatacga taaaagaatc atttttttag gggtatttac
     2041 agtatttaaa attaacttct cagaaataat ttttgcgaca cctgtttttg taactgcatt
     2101 agtaattatg tatgcaagaa ttattatgta aaaattttct gtaaataaaa actgtaaaat
     2161 aacctttatt ggtgcaatgt taaatataaa cgctagaatt acaaaaaaca atgcaacaaa
     2221 agttttttca actgagtcta cagcccatat caagatagtt aaaaaagata agcatataga
     2281 aaattttatg ttgaaactgt aattaagaga gaagtagaga attatggtag ctataacagt
     2341 catataaaat tgttttggct taagaataat acccattttt atattcacct ccataattta
     2401 ttatatcata atggaggtga atacaatgaa tgtgaataca ttttataaaa agattattca
     2461 ttgattctat gatttacaat agctttagtt ttccaatgtc ctttcttata gtagataact
     2521 gtaacaataa gacctaaagt ccaaccaaaa ggaataccca tccaaattcc gtctgttcca
     2581 aaaaatttag aaagcatata agaagctgga agtcttccaa gccataaaga tactattgag
     2641 cttataagtg caaacatgga atcaccagca cctttcattg cacttgaaag tacaaaagaa
     2701 gttccaataa ataagaagaa tggtcctatt ataaataagt aagaagagcc aattttaatg
     2761 acatctttat cagtattgaa tagagcaatt agattttccc taaatagcaa aattaaagca
     2821 ataactgtaa ctgctaaaac taaggtcatt tttatagatt ctcgaatgcc ttttttaact
     2881 ctttcatttt ctccagcacc tatgttttga gcaacaaaag tagaaacagc agaaccaaga
     2941 ttcataatag gtaagcttat aaaattttct atcctaagac cagcaccaaa agctgccata
     3001 gcagatgtac cataactatt aactaaaaat tgaagagcca tatttccaat tgaaaacaac
     3061 atttgttgaa ctccacttgg aagtcctaat ctaagtccat ctttaaatat tttgttatca
     3121 tatacaattc ccttgatttt aaatttaagc acttcatgtt ttttatttaa ataaattata
     3181 cttattataa atgatactgc ctgagccatt atagtggcaa gtgcaacgcc ctcaacaccc
     3241 attcttagca ctacaataaa agttaagtct aaaactatat ttagaattgt ggctattatc
     3301 agaaaataaa gtggagttac tgaatctcca agtcctctaa gtattgcact tactgaatta
     3361 tatccagcag aaaataatat tccactaaat attatagtaa gatacaattt tgattgagca
     3421 aaaacggatt ctggtgtatt cataagctta agcattgggc caccaaatac tattccaaga
     3481 atacttatta atatagaacc aataaataaa agtatatatg tagtatcaat agtagctttt
     3541 acctttttta aatctcctga gccataaaat tgtgacacta aaatagaaaa tccaaggcta
     3601 acacccataa gcgctgccac caataaaaac attatagggt tagctccaga gactgccgcc
     3661 attgcttctt ttccaataaa tctaccaact attatactgt cagctgtatt gtatagttgt
     3721 tgaaataaac taccaataag cataggcatg gcaaaaaaga atatggactt tccctcatga
     3781 cctgtagtta aatctttcac attattcctc caaataaaaa aattattaat ttattatagt
     3841 ataatcttaa cataaacttt atatccaaac tataaataaa ttgtatcaaa atatc
//
LOCUS       DAEQCW010000193         3829 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.194, whole genome shotgun sequence.
ACCESSION   DAEQCW010000193 DAEQCW010000000
VERSION     DAEQCW010000193.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3829)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3829)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3829
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.194"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(44..1234)
                     /locus_tag="KRO40_003503"
     CDS             complement(44..1234)
                     /locus_tag="KRO40_003503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBH2094296.1"
                     /translation="MISNKMQTLVANSSVIRAMFEEGKKLSDIYGEENVFDFSIGNPS
                     VEPPETIKAVINDILNEESPNLVHGYMNNSGYEDVRDAIAEHINKKDGLNLTRENLIM
                     TCGAAGGLNIILKTLLNPGDEVIAFAPYFGEYKNYTENYDGKLIEVPTNIETFEPDLD
                     ALKNAITPKTRALIINTPNNPTGVIYSEELLKNLGELLDSKQKEFNTSIYLISDEPYR
                     EIIYDGAKVPCVLKYYRNSFIGYSYSKSLSLPGERIGYIVANGQMDDFDDVMSSLNVA
                     NRILGFVNAPSLFQRVIARSLDAEVDVNIYKKNFDLLYNSLIDMGYSCVKPNGTFYLF
                     PKAPIEDDKKFCNDAKQFNLLLVPGSSFGCPGHFRVSYCVSYDKVKSSLPAFEKLAKL
                     YNLK"
     gene            1540..1986
                     /locus_tag="KRO40_003504"
     CDS             1540..1986
                     /locus_tag="KRO40_003504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2094297.1"
                     /translation="MDFKNLQYESLSYIICNLQKNFKLYCEKCLKPYKLTNGLYFYLI
                     YINKNRNCSLNDVSTEFEVDKAHTTRTISRLEQDGYIEKIQNPNDSRAFQLRVTDKGE
                     EVLGDIKNIFSKWDNHIKKEFSDTEYKELVKNLHVVKDIKTAVEEE"
     gene            1988..3082
                     /locus_tag="KRO40_003505"
     CDS             1988..3082
                     /locus_tag="KRO40_003505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="HBH2094298.1"
                     /translation="MYCNLLKPIKIGNLELKNRVSFAPTSMGLKLEEKIKKFSDIAKS
                     GVALITLGDVSIRPSFHKVAISLSDEDGVIKYKKIVDEIHNSGAKVSAQLFCSDYDVN
                     LIKDTMNMGITSHDEIKKIMNDGVKDYITNMPKEEIKNIINLFKVTALNAKKAGFDMI
                     QIHGDRLVGSFSSSIFNNRNDEYGGTCDNRSRFASEIISSIRDEVKDIPIDYKFAIRQ
                     ENPHYGNAGVLLSEVEYFVKKFESLGVNSFHVTLANHSKLEDTIPTNNHPYFKDEGCF
                     LYLADEVKKHTNLPVCGVGKLSSPDFIESIISNNRVDMVSMSRQLLADSNWLQKVKDG
                     RVDEIKKCCYCNKKCADALQTRSQFGCILD"
     gene            3170..3700
                     /locus_tag="KRO40_003506"
     CDS             3170..3700
                     /locus_tag="KRO40_003506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBH2094299.1"
                     /translation="MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYGIDY
                     ENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTMGASKKGSYGASIIEKIESI
                     IPKDNEILGSFICQGKIAEGLKAKYKEMLKLSPDNEHIRQQLNNHEESQSHPDEQEIY
                     EASMFAKNMMIKASIV"
BASE COUNT         1501 a          451 c          580 g         1297 t
ORIGIN      
        1 ttctatacta aggtagttaa ttatttgaat tactttgatt tagttatttt aaattatata
       61 atttggctaa tttttcaaat gctggtaaag aacttttaac tttatcataa gatacacaat
      121 atgatactct aaaatgacct ggacaaccaa aagaagaacc tggtactaat aataaattaa
      181 attgttttgc atcattgcag aattttttat catcttcaat tggagctttt gggaacaaat
      241 agaatgtacc attaggttta acacaagaat atcccatatc gattaaacta ttatatagaa
      301 ggtcaaaatt ctttttataa atatttacat caacttctgc atctaaactt cttgcaataa
      361 ccctttgaaa aagagaagga gcatttacaa atccaagtat tctatttgca acatttaatg
      421 aagacataac atcatcaaaa tcatccattt gcccattagc aacaatatat cctatacgtt
      481 caccaggtag agataatgat ttactataag agtatcctat aaatgaattt ctatagtatt
      541 ttagtacaca aggaacttta gcaccatcat aaattatttc tctatatggc tcatcagaaa
      601 ttaggtatat gcttgtatta aattcttttt gttttgaatc caataattct ccaagatttt
      661 ttaataattc ttcagaatat atgacaccag taggattatt tggagtgttt attattaaag
      721 ctcttgtttt tggagtaata gcatttttta gagcatctaa atctggctca aaagtctcta
      781 tatttgtagg aacttctatt aattttccat catagttttc tgtataattt ttatactcac
      841 caaaatacgg tgcaaaagca ataacttcat caccaggatt taaaagagtt tttaaaataa
      901 tatttagacc accagcagca ccacaagtca taattaaatt ttctcttgta agatttaatc
      961 catctttttt atttatgtgt tcagcaatag catctcttac atcctcatat cctgagttgt
     1021 tcatatatcc atgaactaaa tttggagatt cttcatttaa aatatcattt ataactgctt
     1081 taatagtctc tggaggttca acacttggat ttcctatact aaaatcaaaa acattttcct
     1141 caccataaat atcagaaagt ttctttcctt cttcaaacat agctcttata acagaactat
     1201 ttgcaactaa agtttgcatt ttattagata tcatatgtaa cactcctttt tatagattta
     1261 tattgcttat gtatatatta ccatattttt actgaattta gacaattttc gaaaaattac
     1321 ttgtttgaaa atataaactt ttatataaaa tatatttatg tacagtgcat attaaaaatt
     1381 ccaatttcta attttatcat gattatttta tataatagtt ttttaaagaa ttaataaaac
     1441 atagatttag agaataaaat attcttgact atattaattg tttaatataa tatagttgat
     1501 atagtcaaac atattataat tatagaaggg aaatttaaga tggattttaa aaatttacag
     1561 tatgaaagtt tgtcatatat tatttgtaac ttgcaaaaaa actttaaact ttattgtgaa
     1621 aaatgtttaa aaccatataa acttacgaat ggtctatatt tctatttaat ttatattaat
     1681 aaaaatagga attgttcttt gaatgatgtt tctacagaat ttgaagttga taaagctcat
     1741 acaacaagaa ctatatctag gttagaacaa gatggataca tagaaaaaat ccaaaaccct
     1801 aatgatagta gagcttttca gttgagagta acagataagg gtgaggaagt attaggggat
     1861 ataaaaaaca tattttcaaa gtgggataat cacataaaaa aagagttctc ggatacagaa
     1921 tataaagaac tggtaaagaa tttacatgtg gtaaaggata taaaaacagc tgtggaggaa
     1981 gaataggatg tattgtaatt tattaaaacc aattaaaatt ggaaatttgg aattaaaaaa
     2041 tagagtatct tttgcaccta caagcatggg tcttaaattg gaagaaaaaa ttaaaaagtt
     2101 ttctgatatt gctaagtcag gagtagctct gattactcta ggagatgtat ctattagacc
     2161 tagttttcat aaggtagcta taagcctatc ggatgaagat ggagtcatta aatacaagaa
     2221 aattgtagat gaaatacaca attctggtgc aaaggtatca gcacaactat tttgttcaga
     2281 ttatgatgtt aatttaatta aagatactat gaatatggga attacttcac atgatgagat
     2341 aaaaaaaata atgaatgacg gagtaaaaga ttacataaca aatatgccca aagaagaaat
     2401 taaaaatatt ataaatttat ttaaagtaac agcattgaat gcaaaaaaag caggttttga
     2461 catgattcaa attcatggtg ataggcttgt aggaagtttt tcatcaagta tatttaataa
     2521 tagaaatgat gaatatggtg gaacgtgtga taatagaagt agatttgcaa gcgaaataat
     2581 tagtagtatc cgagatgaag ttaaggacat tccaatagac tataaatttg caataagaca
     2641 agaaaatcct cattatggaa atgcaggagt tttactttcg gaagttgagt attttgttaa
     2701 aaaatttgaa tccctaggtg taaacagttt tcatgtaaca cttgcaaatc attcaaaatt
     2761 agaagatact ataccaacca ataatcatcc ttactttaaa gatgaaggct gttttttata
     2821 tttagctgat gaggtaaaga aacacacaaa tcttccagta tgtggggttg gaaaattgtc
     2881 tagcccagat tttatagaaa gtattatttc aaataataga gtagatatgg tttctatgtc
     2941 aagacaatta ctagcagata gtaattggtt acagaaagta aaagatggaa gagtagatga
     3001 gattaaaaag tgctgttatt gtaataagaa gtgtgcagat gctttacaaa cacgctctca
     3061 gtttggatgt atactagatt agaatatcct tataaaaata aataatttgt taaggttaat
     3121 atatttttgg tgatttagat aaatatttag ataaagagga ggagacatca tgaaaagttt
     3181 agttttatat tcaagtttaa ctggaaatac taaaaagatt gcttatacta tatatgatga
     3241 aattcaagaa gaaaaagaca ttaaagatgt aaatgaatta gttgattatg gtattgacta
     3301 tgaaaattat gatatagtat tcttaggcta ttgggtggac aagggaattt gtgataaaaa
     3361 ttcaaaacaa gtgcttgaaa atattcacaa taaaaagata gcactatttg gaacaatggg
     3421 agcaagtaaa aaaggaagtt atggagctag tataatagaa aagatagaat caattatccc
     3481 aaaagataat gaaatactag gttcattcat atgtcaaggt aagatagcag aaggattgaa
     3541 agcaaaatat aaagagatgt taaaactttc tcctgacaac gaacatattc gccaacaatt
     3601 aaataaccat gaggaatctc aaagtcatcc agatgaacaa gaaatatatg aagccagtat
     3661 gtttgcaaaa aatatgatga ttaaagctag tattgtgtag tagttaaaca ataagttcat
     3721 ataagatata gaataaataa tttagtaaaa aagtatagca aataatttgc tatgcttttt
     3781 ttatgaaatc aaaaaaataa taaaaatact tgactgtaaa ccttgttta
//
LOCUS       DAEQCW010000194         3804 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.195, whole genome shotgun sequence.
ACCESSION   DAEQCW010000194 DAEQCW010000000
VERSION     DAEQCW010000194.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3804)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3804)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3804
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.195"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(43..579)
                     /locus_tag="KRO40_003507"
     CDS             complement(43..579)
                     /locus_tag="KRO40_003507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like nuclease domain-containing protein"
                     /protein_id="HBH2094300.1"
                     /translation="MEYKSPVYGIIAVPIEKIESNDYNPNAVAPPEMQLLYKSIKEDG
                     YTMPIVCYYNEEKDKYIIVDGFHRYRVMLENEDIYDRENGLLPVSVIDKSLDERMAST
                     IRHNRARGSHNVDLMSKIITELCEIGKSDEWISKHLGMEVDEILRLKQITGLAYLFKD
                     KEFGNAWIPFGSDIEEEN"
     gene            complement(597..1910)
                     /locus_tag="KRO40_003508"
     CDS             complement(597..1910)
                     /locus_tag="KRO40_003508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3440 domain-containing protein"
                     /protein_id="HBH2094301.1"
                     /translation="MDKRYLESDVFEAFQERLSYLFNEFDYIYVSFSGGKDSGLLLNL
                     VLDYKRKNNISSKIGVFHQDFEAQYSLTTEYVEKVFEDNIEDIEPYWVCLPMATRTAV
                     GNYEMYWYPWDDEKEELWVREMPVKEYIINQKNNPFTYYKYKMRQESLAKQFGRWIRD
                     IHEGAKVVCLLGTRAAESLQRYCSIVNKQHGYKGKCWITKEFKNVWTASPIYDWEIED
                     IWLAHYKFDYDYNKIYDLFYKAGVAPRKMRVASPFNDSAKESLNLYRILDPDVWVKLV
                     ARVQGVNFTSIYGKTKAMGYRSVKLPYGHTWKSFTYFLLDTLPENIRNSYIKKFSTSI
                     EFWQNTGGGLSEIVIRELLRKGYKIELNGVSNHTKDKKSRVIFLDDIPDDTDDIKFTK
                     DIPSWKRMCYCILKNDHMCRFMGFGPTKEQRIRTEYIKKKYEKIH"
     gene            2265..2705
                     /locus_tag="KRO40_003509"
     CDS             2265..2705
                     /locus_tag="KRO40_003509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBH2094302.1"
                     /translation="MYERMLDKSNKPCLSQIIEYIGKDGYARLCKLETYLKTQYNLSR
                     ELRFPFGNNYGWGYKYSHKSFHLFYAFFEKGAFTVLIQIGDKQVPAVEKTLVALTPKA
                     KELWVTRYPCGNNGGWIKYRILEDADLLDIIQYIRAKKSPPKQN"
     gene            complement(2890..3078)
                     /locus_tag="KRO40_003510"
     CDS             complement(2890..3078)
                     /locus_tag="KRO40_003510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094303.1"
                     /translation="MNKNNNLVIICMFIGMILGMAIGCAIGISKGNVGITMCYGLIFG
                     MIIGICIGTVIKNSNKKE"
BASE COUNT         1318 a          653 c          376 g         1457 t
ORIGIN      
        1 ttaatatata tttttctttt aatatatctc ttttatatct ctttaatttt cttcttctat
       61 atcagagcca aagggaatcc atgcattacc aaactcttta tctttaaata aataagctaa
      121 tccagttatt tgcttcaatc taagaatttc atcaacttcc atacccaggt gctttgatat
      181 ccattcatca gattttccaa tttcacaaag ttcagttata attttactca ttaaatccac
      241 attatgagaa cctcttgcac gattgtgtcg aatagtactt gccattcttt catcaagaga
      301 tttatcaatt actgaaacag gaagaagtcc gttttctcta tcatatatat cctcattttc
      361 aagcattact ctatatctat gaaaaccatc tacaataata tacttatcct tttcctcatt
      421 ataataacag acaattggca ttgtataccc atcttctttt atacttttat acaacaactg
      481 catttctggt ggggctactg catttggatt atagtcgtta gattctatct tttcgattgg
      541 cactgcgatg attccatata caggactttt atattccata gcatcttaac tcctatctaa
      601 tgaatttttt catatttctt cttaatatat tccgttctaa ttctctgttc ttttgtagga
      661 ccaaatccca taaatctaca catatggtca ttttttaaaa tacaataaca cattcttttc
      721 caacttggta tatctttggt aaatttaata tcatccgtat catcaggtat atcatccaaa
      781 aatatgactc tactcttttt atcttttgta tgatttgaaa ctccatttaa ttctatttta
      841 taaccttttc tcaacaattc acgtataact atttctgaca aaccaccacc tgtattctgc
      901 caaaactcaa tagatgttga aaatttttta atatagctat tccttatatt ttcaggtaag
      961 gtatcaagca aaaaatatgt gaaacttttc catgtgtgtc catatggcaa tttaacacta
     1021 cgatatccca tagcttttgt tttgccataa atagaagtaa aattaactcc ttgtactcta
     1081 gcaaccaatt tcacccatac atctgggtcc aatattctgt ataaatttaa actctctttt
     1141 gctgaatcat taaaaggtga tgccactctc atttttcttg gagctactcc agctttatag
     1201 aataagtcat aaattttatt atagtcatag tcaaatttat agtgtgctaa ccatatatct
     1261 tctatttccc aatcatatat aggagatgcc gtccagacat ttttaaattc cttagttatc
     1321 cagcactttc ctttatatcc atgctgttta ttcacaatag aacaataacg ttgtagagat
     1381 tctgctgctc gtgttcctaa taagcaaaca acttttgcac cttcatgtat atctctaatc
     1441 catctaccaa attgttttgc caaactttct tgtctcattt tatatttata ataagtaaaa
     1501 ggattatttt tttgatttat tatgtattct ttgactggca tttcccttac ccataactct
     1561 tctttctcat catcccatgg ataccaatac atttcataat ttcctacagc agttcttgta
     1621 gccattggta aacacaccca atatggttca atatcttcaa tattatcttc aaatactttt
     1681 tcaacatatt cagtagtcaa actatattga gcctcaaaat cttgatgaaa tactcctatt
     1741 ttggaactta tattattctt tctcttataa tccaaaacta aatttagcag taaaccacta
     1801 tcttttcctc cgctaaaaga tacatagata taatcaaatt cattaaaaag ataagaaagt
     1861 ctttcttgaa aagcttcaaa tacatcggat tctaaatatc tcttatccat ttgaattatc
     1921 ccctttcaat tagaagttta taaaacctta caatgcaata ttattatgct tttttagcag
     1981 taatcagcat aaattataca ttatttaaat acacaaatcc aactaaatac atataattat
     2041 aatgtaatta tacttttgta ttataaacta tattttatca ttattttaca tttttttcca
     2101 atatatataa ttatcatatt tttctattag ctaaaactaa ttaccttata tttttacgta
     2161 ttggtataat aatacataaa aacttgaata atgcataaaa acttgacata ctgttgtcat
     2221 aattactttg ctataattaa aagtaaaaat ggaggtaaat tctaatgtat gaacgtatgc
     2281 ttgataaaag caataaaccc tgtttgtctc aaataataga atatataggt aaagatggat
     2341 atgcacgatt gtgtaagttg gaaacttact tgaaaactca atataattta tcaagagaac
     2401 ttcgatttcc ttttggaaac aattatggtt ggggttacaa atatagccat aaatcttttc
     2461 atttatttta tgcttttttt gaaaaaggtg catttactgt tctgattcag ataggtgaca
     2521 agcaagttcc agcagtagaa aaaacgttgg tagctttgac accaaaagct aaagaactct
     2581 gggtcactcg ttatccttgt ggcaataatg gaggctggat taagtatcgt attttagaag
     2641 atgcagactt acttgatatt attcaatata taagagcaaa aaaatctcca cctaaacaaa
     2701 attaactttt attttttgtg atttaaatat agtgtatata aattccattc tttccatata
     2761 aaaaaaataa tataaaaaat atctattagt ataacttatt tagtatgtct tattctactt
     2821 tttacagata attaaaaagt tttatcataa ataaatcata actagacatc ctagtaaatc
     2881 aaaattaatt tattcttttt tattagaatt tttgataaca gtccctatac atatgccaat
     2941 tatcattcca aaaattagac cataacacat tgtgatacct acatttcctt tagaaatacc
     3001 tatagcacaa cctatagcca ttccaagtat catgcctata aacatacata taataactaa
     3061 attgttgttt ttattcatag tttttctcca ttcaatatat tttaaattgc ctagctcgcc
     3121 ttcttagctt aaaacaaaga aatataaatt aactttcttt cattctaata tctgcttgta
     3181 taaatgtcaa acaacacatt tcttgtcata acctcctctt tttgaagtaa gtacaatctc
     3241 ccagacgcaa taatatcaat ttcctaaaac catttaagta acttttatat ttacataata
     3301 tttacaatca taaactatat tgttattcat ttatacatca taaacactcc ctcctaatca
     3361 ttattatact taaaataatg ttcatttata ataatatatc taacgcactt taattgaaaa
     3421 aactaaaact ttgcctttca ttcccatata taaataagta tactttttga tgctctatta
     3481 caaatcaact aaattaattg atataaatta tcattttctg ttgaaaatac cattcgaaca
     3541 tgctatactt aattgcataa atggtaataa atgtcatatg attttacaaa tctattaata
     3601 acaattatta cttttactgt attctaaagt ttttggacta aatatcaaga actttctaaa
     3661 atacaaagta caaaaaattt atataagtta taaatttata tgaactagat aagctcaaac
     3721 aatatgttat gtataaactg tgtagtattc ggttataaat ttatataaat tatataagct
     3781 agataaagta ttacctcaac tata
//
LOCUS       DAEQCW010000195         3785 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.196, whole genome shotgun sequence.
ACCESSION   DAEQCW010000195 DAEQCW010000000
VERSION     DAEQCW010000195.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3785)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.196"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(220..2280)
                     /locus_tag="KRO40_003511"
     CDS             complement(220..2280)
                     /locus_tag="KRO40_003511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2094304.1"
                     /translation="MEKYRVLKLVSLIIISISFPLTILLVTIGLAEPKYNIQKTSTKS
                     GIFDISDDFYDSNIFDEGTMASLLPKFKLSVGGKLTSKEKGKFQQEGKSIDLSSSDSE
                     YDKIMINEQASEEYLSYLKNIKVYVINTYTGVFYTNTSYASLYDFKQKTKSYCNVEII
                     NKIGKSSYIKTINGEKFELNNLSLELNEVDEGFEAYVSFPEEPTIEDGIVYTNFQIFK
                     QATEKVRLFFVASLSLAIICLLSIILYIKIKGEVLKRNNVFLLIYSKIPMEFNVILVS
                     ISIAILTIYALAVSYHIDVIALVSLSLLIVSNNIFFINVQLSYLENKMCIFKTSIIVR
                     VILWLIKTVREVSNAIKKVSLARKVIVIVIISLALIMVISTRSIGMGLLFSICIFLGF
                     TIYITKRLSYLSYVIEGTERIKKGELDYKIKITGNDNFTSLAENINNIGEGLDRAIEE
                     QVKSERMKSDLITNVSHDLKTPLTSIINYVDLIKKEESIQPEYINDYINVLESKSKRL
                     KLLIEDLFEASRVSSGNIELQISKIDLVQLLRQSIGELEEKLSKNNLYLKLNVPNDKV
                     YIWADGRRMYRVFENLLSNIAKYSLEETRVYIDVYDYGENVKVTMKNISSYELNFDPS
                     EIMERFKRADESRNTEGSGLGLAIARDLVALQGGKFYIEIDGDLFKANLEFQKYEEEI
                     TNME"
     gene            complement(2476..3168)
                     /locus_tag="KRO40_003512"
     CDS             complement(2476..3168)
                     /locus_tag="KRO40_003512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094305.1"
                     /translation="MYNILVVDDDKEIVDSIEIYLKSEGFKIYKAYDGMKALEIITEN
                     DIHLILMDIMMPKLDGIKATVKIREERNIPIILISAKSEDTDKIIGLNIGADDYITKP
                     FNLLELIARVKSNLRRYVTLGNYEDTCKEILKSGALELNTLTKEVKIDGENIKMTPIE
                     YKIIELLLENKGRVFSIDEIYEKVWNEESFNSENTVAVHIRRIREKIEINPKEPRFLK
                     VVWGVGYKIEKF"
BASE COUNT         1263 a          608 c          324 g         1590 t
ORIGIN      
        1 gaattatctt gtgatatttg gataatgttt tattgtataa gttattttaa aactatgtgt
       61 acaattttaa tttaagttgt tatattattg attttaaata aaaaacagag tgacttaaag
      121 ttactctgtt tttactcttc attctctact gtaaatattc taatatatta taataaaagc
      181 tttcgacagt aaaaaaaata tatatactta aatactatct cattccatat ttgttatttc
      241 ttcttcatat ttttgaaact ctaaatttgc tttaaataaa tctccatcta tttctatata
      301 aaattttcca ccttgtaaag ctactaaatc tcttgcaata gcaagcccta atccacttcc
      361 ttcagtattc cttgattcat cagctctttt aaatctttcc ataatctcac ttgggtcaaa
      421 atttaattca taagaagata tatttttcat agttaccttt acattttcac catagtcata
      481 tacatcaata tagactctag tttcttctaa ggaatatttt gctatattag ataaaagatt
      541 ttcaaatact ctatacattc ttcttccatc tgcccatata tacaccttat catttggaac
      601 atttaatttt aaatataaat tatttttaga taatttttct tcaagttcac ctatactttg
      661 tcttaatagt tgcactaaat caatcttgct aatttgtaat tctatattgc cactacttac
      721 tctactcgct tcaaataaat cttctatcaa taattttagt ctttttgact ttgactcaag
      781 tacatttata taatcattta tatactctgg ttgtattgat tcttcttttt taattaaatc
      841 tacataattt attatagaag taagtggagt tttcaaatca tgagatacat ttgttataag
      901 gtcagacttc attctttcac tttttacttg ctcttctata gctctatcaa gaccttctcc
      961 aatattattt atattttcag ctaaagacgt aaaattatca ttcccagtaa tttttatctt
     1021 ataatctaat tctccctttt ttattctttc tgtaccttct attacgtaac taagatatga
     1081 aagtctttta gttatatata ttgtaaatcc taaaaaaata catatagaaa acagtaatcc
     1141 catacctata cttcgagtgc taattaccat gattaaagct aaagatatta tcactataac
     1201 aataactttc cttgctaaag atactttctt tatagcgtta ctgacctccc ttacagtttt
     1261 tattaaccat aaaatcactc ttactataat acttgtctta aatatacaca ttttattttc
     1321 taaataactc aattgcacat ttataaaaaa tatattattt gatactatca gtaaagataa
     1381 agaaactaat gcaattacat caatatgata agatacagca agagcatata tagttaaaat
     1441 tgcaattgaa atagatacta atattacatt aaattccata ggtatcttac tgtatattag
     1501 taaaaataca ttatttcttt ttaaaacttc accttttatt ttgatatata aaattataga
     1561 taataaacat ataattgcta aacttaaact agctacaaaa aataatctta ctttttctgt
     1621 agcttgttta aatatttgaa aattagtata tactattcca tcttctatag ttggctcttc
     1681 tggaaaagat acatatgcct caaaaccttc atctacttca tttagttcca gactcagatt
     1741 attcagttca aatttttctc catttattgt tttaatatat gagctctttc ctatcttatt
     1801 tattatctct acattacaat agctcttagt tttttgttta aaatcatata aactagcata
     1861 tgacgtattt gtataaaata ctcctgtgta tgtattaata acatacactt ttatattttt
     1921 tagataactt aaatattctt cagaagcttg ttcattaatc atgattttat catactcaga
     1981 atcactacta cttaaatcta tacttttacc ttcttgttgg aatttacctt tttctttact
     2041 agttaattta ccacctacag atagcttaaa cttgggtaat agacttgcca ttgttccttc
     2101 gtcaaatata ttactatcat aaaaatcatc agatatatca aaaatcccac tctttgtaga
     2161 agttttttgt atattgtatt taggctcagc aagtcctatt gtcaccaaca atatagttaa
     2221 tggaaatgag atagatatta tgattaatga aactaacttt aatactctat atttctccaa
     2281 gttgcccacc tcatctacat tgtcagtatt ttatataaaa taaagtttaa gaaaagcata
     2341 atccccatag agtaaattaa actctcagag aaaaaattaa aacatattaa aattcctaac
     2401 atttgtgtaa atgtaaaaat gactaaaatc aaaatgcaat taaatattaa actcttttct
     2461 tttataattt ttccactaaa atttttcaat cttataacca actccccaca ccacctttaa
     2521 aaatcttggt tcttttggat ttatttcaat cttttctctt attcgtctga tatgtactgc
     2581 tactgtattt tctgaattaa aactttcctc attccatact ttttcgtata tctcatctat
     2641 tgagaaaact cgtcctttat tttctaaaag aagttcaatt attttatact caattggagt
     2701 catttttatg ttttcaccat caattttaac ttcttttgtt agtgtattta actccaaagc
     2761 tccacttttt aaaatttctt tacatgtatc ttcataatta cctaaagtta catatcgtct
     2821 taagtttgat ttaaccctag ctataagctc taatagatta aatggctttg ttatataatc
     2881 atcagctcca atatttaatc ctattatttt atctgtatct tcactttttg ctgaaattaa
     2941 aattattgga atatttcttt cttctcgtat ttttacagtt gctttgattc catctaattt
     3001 aggcatcatt atatccatta gtattagatg aatgtcattc tctgttatta tttccaaagc
     3061 tttcattcca tcatatgctt tatatatttt aaatccttct gatttaagat atatttctat
     3121 cgaatcaaca atttctttat catcgtctac tactaatata ttgtacatat tttcacttcc
     3181 tctattgtat aataatactt atctatatta tacaatatct ttcactccct ttctcaacaa
     3241 tgactaaatt gttatattac tttggcttac atttttgtaa ctttccctta taactatata
     3301 ataaaatata aatcttaaga aaatattatc ctaattctta aatatttctt aagatttaag
     3361 ataaattgag gtttatttga ataaattgat ttgaattatg ttgttttcag attactttca
     3421 tttaagtatt ttgattgcat tcagctgaat tgatgtatat taattcttat tgaacagttt
     3481 ttattttttg ggtggaagaa tggtggaaga attacatttc actaactttc ttccaccatt
     3541 cttccaccca aatatactta gaaacattca tttcactgca ataatagcta cttatttaaa
     3601 ttctattttt atacattcta tctactatat actgtacata ttctattaaa atttatataa
     3661 ctaaaataca aacttatttc attttcttaa catgttcaga ataataaaca aaatgaaggt
     3721 agaaaaagtt ataatttcat accttcattt tatttattat gtatcaattt gtcattttct
     3781 tattt
//
LOCUS       DAEQCW010000196         3774 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.197, whole genome shotgun sequence.
ACCESSION   DAEQCW010000196 DAEQCW010000000
VERSION     DAEQCW010000196.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3774)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3774)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3774
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.197"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            248..397
                     /gene="rpmG"
                     /locus_tag="KRO40_003513"
     CDS             248..397
                     /gene="rpmG"
                     /locus_tag="KRO40_003513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004402360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HBH2094306.1"
                     /translation="MRVKVTLACTECKQRNYNTTKNKKNNPDRIELQKYCRFCKKHTT
                     HKETK"
     gene            423..644
                     /gene="secE"
                     /locus_tag="KRO40_003514"
     CDS             423..644
                     /gene="secE"
                     /locus_tag="KRO40_003514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HBH2094307.1"
                     /translation="MAAQKNDGAKTKKRFSLFGYLKETKQELKRVTWPTKKELFKNTS
                     IVLTVVISCTILVWGIDTILSGALALLLK"
     gene            664..1206
                     /gene="nusG"
                     /locus_tag="KRO40_003515"
     CDS             664..1206
                     /gene="nusG"
                     /locus_tag="KRO40_003515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination factor
                     NusG"
                     /protein_id="HBH2094308.1"
                     /translation="MSELQEASWYVVHTYSGHENKVKATIEKAVKTRGMEDCIRQVVV
                     PTEEVVETTKTGKEKTRQRKVYPSYVLVKMIITDESWYVVRNTKGVTGFVGPGSKPVP
                     LSEDEVKAMGIDTTDPKVVNSDIDFEIGDTVKVSQGPFSGQIGNIEEIDLENREVKVC
                     INAFGKRTLFVIELEGIEKI"
     gene            1245..1670
                     /gene="rplK"
                     /locus_tag="KRO40_003516"
     CDS             1245..1670
                     /gene="rplK"
                     /locus_tag="KRO40_003516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HBH2094309.1"
                     /translation="MAKKVIGQIKLQIPAGKATPAPPVGPALGQHGVNIMGFTKEFNA
                     KTADQAGMIIPVVITVYQDRSFSFITKTPPAAVLIKKALNLKSGSGEPNKKKVAKMTS
                     AQVREIAELKMPDLNAASVEAAMSMIAGTARSMGVVIED"
     gene            1741..2439
                     /gene="rplA"
                     /locus_tag="KRO40_003517"
     CDS             1741..2439
                     /gene="rplA"
                     /locus_tag="KRO40_003517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HBH2094310.1"
                     /translation="MAKKGKRYAGALQKVDRTKFYDASEALTLVSDIAGAKFDETVEA
                     HIKLGVDSRHADQQVRGAVVLPHGTGKTKRVLVFAKGEKAKEAEQAGADFVGAEELVQ
                     KIQGENWFDFDIVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIDEIKAG
                     KVEYRLDKTNIIHVPVGKVSFGGEKLTENFTALMDAIIKAKPAAAKGQYLRSITVASS
                     MGPGVKINPARTAE"
     misc_feature    2491..2619
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            2662..3168
                     /locus_tag="KRO40_003518"
     CDS             2662..3168
                     /locus_tag="KRO40_003518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HBH2094311.1"
                     /translation="MRKAIEIKSEVVSEIVEKLQKSSAAVVVDYKGLTVEEVTELRKQ
                     MREAGVDYKVYKNTLVRRAAKEVGIEQFNDELLVGTNAIAFGYDDPVAPARILKGFMD
                     SHPKMKLKMGIVEGAFYDESKIVEMANIPSREVLIAKLLGSLKAPVSNFAYLIDAIAK
                     KAEGQEEA"
     gene            3226..3591
                     /gene="rplL"
                     /locus_tag="KRO40_003519"
     CDS             3226..3591
                     /gene="rplL"
                     /locus_tag="KRO40_003519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HBH2094312.1"
                     /translation="MTIEQILEAIENMKVLELNELVKAAEEKFGVSASAPVMVAGAAA
                     GGPAAEEKTEFDVVLTDVGSSKVGVIKAVREITGLGLKEAKEVVDNAPKTVKEGASKE
                     EADQIKEKLEAAGAKVEVK"
BASE COUNT         1526 a          452 c          748 g         1048 t
ORIGIN      
        1 ctttactaaa ctgatggatt aaaaggaata acaaaaagag gggttatgct cctctttttt
       61 taacatagaa atacaaaaac attgacacag cataggattt tgtgataact tatacaaggt
      121 aatgattata ggaagttaat aatatcttga atactgtaga tttttaataa atacatattt
      181 taaagatatt atattcacat atattaacaa tatatattat tgtattacaa agttggaggt
      241 gtatcagatg agagttaaag taactttagc atgtacagag tgtaagcaaa gaaactacaa
      301 cactactaag aataagaaaa acaatccaga cagaatagaa ttacaaaaat attgtagatt
      361 ctgtaaaaag catacaactc ataaagaaac aaaatagttt tttataagga tgtgagtatg
      421 gaatggctgc ccaaaaaaat gacggtgcaa aaactaaaaa aaggtttagt ttgtttggat
      481 acttaaaaga aactaaacaa gaattaaaaa gagttacatg gccgacaaaa aaggaactgt
      541 ttaaaaacac aagtatagtt ttaactgtag ttatttcatg cactatatta gtatggggta
      601 tagacactat attatctggt gcactagcgt tattactaaa atagacgaaa agaggtaagt
      661 taaatgtcag aattacaaga agcaagttgg tatgtagttc atacctattc gggacatgaa
      721 aataaagtta aagctacaat tgagaaagca gttaaaacaa gaggtatgga agactgcata
      781 agacaagtag ttgttccaac agaagaagta gtggaaacta ctaaaactgg aaaagaaaaa
      841 actagacaac gtaaagttta tccaagttat gttttggtta aaatgataat aactgatgaa
      901 tcttggtatg tagtaagaaa tactaaggga gttacaggtt tcgttggacc tggttcaaaa
      961 ccagtgccat taagtgaaga cgaagtcaaa gctatgggga tagacacaac agaccctaaa
     1021 gtagtaaata gcgatattga ttttgaaata ggagatacag taaaagtatc tcaaggacca
     1081 tttagtggac aaataggtaa catagaagaa attgacttag aaaatagaga agtcaaagta
     1141 tgcataaatg catttggtaa aaggactcta tttgtaatag agcttgaagg tatagaaaaa
     1201 atctaatact atattataga aaaatctgag gaggtgcgct caaaatggct aaaaaagtta
     1261 taggtcaaat aaaattacaa atacctgcag gaaaggctac tccagcgcca ccagttggac
     1321 cagcattagg acaacatggt gttaatataa tgggattcac aaaagaattt aatgctaaaa
     1381 ctgcagatca agctggaatg ataataccag ttgttataac tgtatatcaa gatagatcat
     1441 tcagttttat aacaaaaact ccaccagctg cagttttaat taaaaaagca ttaaacttaa
     1501 aatcaggttc tggagaacca aacaagaaaa aagttgctaa aatgacttca gctcaagtaa
     1561 gagaaatagc tgaattaaag atgcctgact taaatgctgc atcagtagaa gctgctatga
     1621 gtatgatagc tggtactgct agaagcatgg gtgttgtaat cgaagactaa ttaaaagata
     1681 cacttttttt tataaagtgg gaggctagaa gccgaaatta accacgagga ggaaaataaa
     1741 atggctaaaa aaggtaaaag atatgcaggt gcattacaaa aagtagatag aactaaattt
     1801 tatgatgcat cagaagcatt aacattagtt tcagatatag ctggagctaa atttgatgag
     1861 acagtagaag cacacattaa attaggtgtt gactcaagac atgctgacca acaagtaaga
     1921 ggtgcagttg tattacctca tggaactggt aaaacaaaaa gagttttagt ttttgctaaa
     1981 ggtgaaaaag ctaaagaagc tgaacaagct ggtgctgact ttgtaggagc tgaagaatta
     2041 gttcaaaaaa tacaaggtga aaactggttt gactttgata tagtagttgc tactccagat
     2101 atgatgggtg tagtaggtag attaggtaga gtattaggac ctaaaggttt aatgccaaac
     2161 cctaaatcag gaacagttac atttgatgta gctaaagcta tagatgaaat aaaagctggt
     2221 aaagttgaat acagattaga caaaactaac ataatacacg ttccagtagg aaaagtatca
     2281 tttggtggag aaaaattaac tgaaaacttt actgcattaa tggatgctat aataaaagct
     2341 aaaccagctg ctgctaaagg acaatattta agaagtataa cagtagcttc ttcaatggga
     2401 cctggagtta aaataaaccc agcaagaaca gctgaataat aaaactgttg acacaggttg
     2461 acaaaaatgt tattatatca cttgtcaatg taaaaaagaa tagatttgcc gtagatagtg
     2521 ggtgcgagag cttaatatcc cgccgaggtt ttagataaat tgagattact aaagcttttg
     2581 atgtctactt ttggcaacaa aagcttttta taatgttgcg gtaaatacta agcctatttg
     2641 gtgaaggagg tgcacatcta tatgagaaaa gctatagaaa ttaaatcaga agttgtttct
     2701 gagatagttg aaaagttaca aaaatcttct gctgctgttg ttgtagatta caaaggatta
     2761 acagttgaag aagtaactga gttaagaaaa caaatgagag aagctggtgt agattacaaa
     2821 gtatacaaaa atactttagt tagaagagca gctaaagaag ttggtataga gcaatttaat
     2881 gatgaattat tagttggaac taatgccata gcatttggat atgatgatcc agttgctcca
     2941 gctagaatat taaaaggatt catggattct catccaaaaa tgaaattaaa gatgggtatt
     3001 gtggaaggtg cattctatga tgaatctaag attgttgaaa tggctaacat accatcaaga
     3061 gaagttctta tcgctaaatt acttggtagc ttaaaagctc cagtatcaaa cttcgcatac
     3121 ttaatagatg caatagcgaa aaaggcagaa ggtcaagaag aagcttaatt gcttaactaa
     3181 aaaattataa atattaattt gaaataaaat tcggaggtgc taaaaatgac aatagaacaa
     3241 atattagaag ctatagaaaa tatgaaagtt ttagaattaa atgaattagt taaagctgct
     3301 gaagaaaaat tcggtgtatc agcttcagct ccagtaatgg tagctggtgc agctgctggt
     3361 ggaccagctg ctgaagaaaa aactgagttt gatgtagtat taactgacgt tggttcttca
     3421 aaagttggag ttataaaagc agttagagaa ataacaggat taggattaaa agaagctaaa
     3481 gaagtagttg acaatgctcc taagacagtt aaagaaggag cttctaaaga agaagctgat
     3541 caaataaaag agaaattaga agctgctgga gctaaagtag aagttaagta gtttctttaa
     3601 aaagataccc attgggtatc tttttttatt tataaaaaac tataaagaaa gtatttggaa
     3661 ttataaagaa agtattttta taaaataaaa aaaatttata taatagtact aaattaaggg
     3721 tatcatatat ggtgtaatgg tattttaatt taacattatt atcaaattaa aata
//
LOCUS       DAEQCW010000197         3695 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.198, whole genome shotgun sequence.
ACCESSION   DAEQCW010000197 DAEQCW010000000
VERSION     DAEQCW010000197.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3695)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.198"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            42..548
                     /locus_tag="KRO40_003520"
     CDS             42..548
                     /locus_tag="KRO40_003520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HBH2094313.1"
                     /translation="MKEYVVVDLETTGLDPYKGCEIIEIGITEIKNEQIVKNYSRLIK
                     PKGIISSFITELTHISNEMVENEEPLELVLPRFRKYIGDRTIIAHNAKFDLKFLNYYL
                     RMLDLEPINNYICTVELLKKCKSYKGKNKKLETACAYYNIENINAHRADSDTLATAKL
                     FLKIKDEY"
     gene            676..1692
                     /locus_tag="KRO40_003521"
     CDS             676..1692
                     /locus_tag="KRO40_003521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBH2094314.1"
                     /translation="MGYYNDNDNNKIRRKKISNNKDSNKKSKHSYTSANKKNKSPNTS
                     SSKRMSEKVDSQNLIKRDRDSFTRDNVRPLNTDYNQRERRRVEYKQREKKLKSKKRKK
                     QKRIRIVRALLSIMLVALIIFSVAGAIFTVSAIKGSPEVTKKLIRSKYISSEVVSIKQ
                     MPNDLKHAIVSIEDERFYKHKGVDVISLVRSVLNNVFTDTTQGASTIDMQVSKNLLTS
                     NDKTMKRKIRDMYNAKQMNKIMTKDEILEAYLNNMYLGKNAYGAAKGAEVYFGKKVSE
                     LNLAECAMLAGMTNNPARYIDHGEAKKRQVIVLYKMHQLGYITDKEYRIAKADDTPFK
                     SEID"
     gene            2046..2750
                     /locus_tag="KRO40_003522"
     CDS             2046..2750
                     /locus_tag="KRO40_003522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B3/4 domain-containing protein"
                     /protein_id="HBH2094315.1"
                     /translation="MKKFVIEDAFWNLFPSAKIGVVICNDIDNSIKDEDYKKIILKGE
                     EEALKYLEDSEFSNNQVIKVWREAFKKFKTKKGARSSIEALLKRVHNGNNIGTINPLV
                     DIYNFISLKYALPCGGEDIDKFIGDIRLTRAIGNEEFIPLGTDENSFPYEGEIIYKDD
                     GGAICRCWNWREAVRTMLTEDTNNAFLCIELVDESRFKEFENALNELAKIVQEKLGGN
                     CKISILDIDNKEVSVD"
     gene            3045..3524
                     /locus_tag="KRO40_003523"
     CDS             3045..3524
                     /locus_tag="KRO40_003523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2975 domain-containing protein"
                     /protein_id="HBH2094316.1"
                     /translation="MSNKLIKNLLSGILQILFFLLGLVIVVGGFKSFMYLCFSGEATL
                     QGTIYGILMFILGVSYFIIIKSLIEVLGSSEYSLFVKENVKRFRIIGYLLLLNSLIEF
                     ISTFGTTGKGMRFLDLGFGFYFTVPVFVYFITSLMSFVIADGFVKAIKIKEDNDLTI"
BASE COUNT         1529 a          331 c          635 g         1200 t
ORIGIN      
        1 tagaatataa atatatccat ttaataataa ggagaagaga tatgaaagag tatgtagttg
       61 tggatttaga aactacagga ttagatccat ataaaggttg tgaaataata gaaataggaa
      121 taacagaaat aaaaaatgaa caaattgtaa aaaactattc aaggttgata aaacctaagg
      181 ggataatttc ttcatttata acagaattga cacatataag taatgaaatg gtagaaaatg
      241 aagaaccact agaattagtt ttacctagat ttagaaaata cataggtgat agaactataa
      301 ttgcacacaa tgcgaaattt gatttaaaat ttttaaatta ctatcttaga atgttagatt
      361 tagaaccaat aaacaattat atatgtacag tagagttatt aaaaaaatgt aaaagttata
      421 aaggaaaaaa caagaaactt gaaacagctt gtgcttatta caacatagag aatataaatg
      481 ctcatagagc tgacagtgat acattagcaa ctgcaaaact atttttgaaa ataaaagatg
      541 aatattaatt ataaatatag agaaaattag tgaaaatatc ctttataaaa ttgaccctta
      601 agcttacaat tttgttcttt gatttatttt gtagaacaat gtataatgta ccttatatga
      661 agaagggaga ctaaaatggg ttattacaat gataatgata ataataaaat aagacgtaaa
      721 aaaattagta acaacaaaga tagtaataaa aaatctaaac attcttatac ttcggcaaat
      781 aaaaaaaata aaagtcctaa tacaagttcc agtaaaagaa tgagtgaaaa agtagattca
      841 cagaatctta taaaaagaga tagagatagt tttacaagag ataatgtaag acctttaaat
      901 acagattaca atcaaagaga aagaagaaga gtcgagtata aacaaagaga gaaaaaatta
      961 aaaagtaaaa aaagaaaaaa acaaaaaagg attagaatag ttagggcatt attatctatt
     1021 atgttagttg cactaattat attttcagtg gcaggtgcaa tatttacagt ttcagctata
     1081 aaagggtcac cagaagttac taaaaagtta attaggtcta aatatataag tagtgaggtt
     1141 gtaagtataa aacaaatgcc aaatgattta aaacatgcaa tagtttccat agaagatgag
     1201 agattttata agcataaagg agtagatgtt atttctctag ttaggtcagt attaaacaat
     1261 gtgtttacag atacaacaca aggtgcaagt actatagata tgcaagtttc aaaaaacctg
     1321 cttactagta atgataaaac tatgaagcgg aaaataaggg atatgtataa tgctaagcag
     1381 atgaataaga ttatgactaa ggatgaaatt cttgaagcat atttaaataa tatgtatcta
     1441 ggtaaaaatg catatggagc tgcaaaggga gctgaagtct actttggtaa aaaagttagt
     1501 gaattaaatt tagctgagtg tgctatgtta gctggtatga caaataatcc tgcaaggtat
     1561 attgaccatg gagaggctaa gaagagacaa gtgattgtac tgtataagat gcatcagctt
     1621 ggttatataa ctgataagga gtatagaata gcaaaagctg atgacactcc atttaaatca
     1681 gaaattgatt aaaattgtaa gaatatagta ttttcaatag tttaaacaaa caaaaatgta
     1741 ataaaaaagg tgatttgcca cccatttgcc accataatta taatctaatg gcaaattgtt
     1801 ttaatgtaca aactagataa tagaatattg tcttaaatgc tatattatgc taaaatttaa
     1861 ttgtattttg taaattaaaa aacttataat ttagttttct agggttccgc attttataat
     1921 ggtcaggtcc aagagaaaac gcgcaattgt tgtgtacacg gaaggataaa agcctgggag
     1981 atatttaaga atatttctat aggctttttt atttttacat attttaaatt tgaggaggtt
     2041 ttctaatgaa aaaatttgtt attgaggatg cattttggaa tctatttcct agtgcaaaaa
     2101 ttggagttgt tatttgtaat gatatagata actctataaa agatgaagac tataagaaaa
     2161 taattttgaa gggagaagaa gaagcattaa aatacttgga ggactcagaa tttagcaaca
     2221 accaagtgat taaagtatgg agagaagcat ttaaaaaatt taaaacgaaa aaaggagcaa
     2281 ggtcttctat tgaagcatta ttaaaaagag ttcataatgg aaataatata ggaactatta
     2341 accctttagt ggatatctac aattttatct cattaaaata tgcattacct tgtggagggg
     2401 aggatataga taaatttata ggagatatta ggctaactag agcaattggt aatgaggagt
     2461 ttatcccact agggacagat gaaaattcat ttccatatga aggagaaata atttataaag
     2521 atgatggtgg agcaatttgt agatgttgga attggcgtga agcagtgaga acaatgctta
     2581 ctgaagatac taacaatgcc tttttatgca ttgaattagt agatgaaagt agatttaaag
     2641 aatttgaaaa tgctttaaat gaattagcta aaatagttca agaaaaattg ggtgggaatt
     2701 gtaaaatttc aattttagat attgataata aagaggtatc agtggattaa tatggaggtg
     2761 ctgttgtaat ggactattct agttataaag atacttatat ttagggtaag aaggtctatt
     2821 ttagatataa cgattatcaa aggatataat atagaaaata aaaatgtaga atataaaaag
     2881 cctttaaaat aagaaaaaaa tgtattttaa aggcttttat tatactcttt tttatttgca
     2941 taattaacaa taaaaatata ttgttaatta taatattttt atttaaaaac gatataatat
     3001 aatgtattat actatatata aaatatttta aaggagttgg catgatgtct aataaactta
     3061 taaaaaattt actaagtggt atattacaaa ttttattttt tcttttagga ttagtaattg
     3121 ttgtaggagg atttaaaagt tttatgtacc tctgttttag tggagaagca actctacaag
     3181 gtactattta tggaatatta atgtttattt taggtgtatc atattttatc attataaaat
     3241 cattgataga agtattaggt agttctgaat atagcctatt tgtaaaagag aatgtaaaaa
     3301 gatttaggat tattggatat cttttgcttt taaactctct aattgagttt atttcaactt
     3361 ttggtactac tggaaaagga atgagatttc tagatttagg atttggattt tattttactg
     3421 ttccagtatt tgtatatttt ataacttctc tgatgagttt tgtaattgca gatggatttg
     3481 taaaggcaat aaagataaaa gaggataatg atttaactat ttaggtgtga cactttaata
     3541 tataggagat aaataacccg aaaagagtga ctaactagta atttaaaata aaatatatta
     3601 gggtataata cataaactat aatgctaaaa ttaaaagatt ataatactaa aatataatta
     3661 tgttttaatt aaaataaaga actttattag tagat
//
LOCUS       DAEQCW010000198         3628 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.199, whole genome shotgun sequence.
ACCESSION   DAEQCW010000198 DAEQCW010000000
VERSION     DAEQCW010000198.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3628)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.199"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(185..940)
                     /locus_tag="KRO40_003524"
     CDS             complement(185..940)
                     /locus_tag="KRO40_003524"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBH2094317.1"
                     /translation="MLKVIISGYNGTMGRVLAECVKKDNELELVCGVARSADEKGHHS
                     DTKLYKTMTDVAEKTDVIIDFSHHETLEPILSYALKNNTPVVLATTGYDENDLNKIEE
                     ASKNIPILLSSNTSLGVNILIKLVKDASKMLEGFDIEIIEKHHNRKEDAPSGTATMIA
                     NAIREVLPESENTHGRYGRDCKRKSNEIGIHSIRGGNIISDHDVVFAGDNEVLTLSHH
                     SQSDEVFANGSIVAAKFLIGKQSGLYKMSDILG"
     gene            1380..2369
                     /locus_tag="KRO40_003525"
     CDS             1380..2369
                     /locus_tag="KRO40_003525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HBH2094318.1"
                     /translation="MLKEEKTYQEKDAKVFNGVAALIMILLFLVVSIGIMVFGIVKLD
                     SGFTGIGSLMLILGLVFIVVDFILFFGLKMINPKEAIVLVLFGNYYGTIKKEGYYWVN
                     PFCSAINPAVSRINVSKSSSDEKVDISTNSSGKKVSLKTMTLNNEKQKVNDLLGNPII
                     IGVVVIWKVIDATKAVFNVDNYNTFLSIQCDSTIRNVSRLYPYDVSEDGDEKSLRGSS
                     QEIADRLKDELQSRVDIAGIEVCEVRITHLSYAPEIAAAMLQRQQAEAIIAARKKIVE
                     GAVSMVEMALTNLSENNVVTLDEERKAAMVSNLLVVLCGNKDAQPVVNSSSIY"
     gene            complement(2821..3537)
                     /gene="dapD"
                     /locus_tag="KRO40_003526"
     CDS             complement(2821..3537)
                     /gene="dapD"
                     /locus_tag="KRO40_003526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HBH2094319.1"
                     /translation="MVNLNDAYEIARYIKEVKKKTPVKVYVNTNSLHFQSTDKFKVFG
                     SNGSYIFVGDYEDIMEVLDKHGNDITDTHVEYDRRNSAIPLKNTLSEHARIEPGAIIR
                     DMVTIEKNAVVMMGAVINIGAVIGEGSMVDMNAVIGARGTLGKNVHLGAGAVVAGVLE
                     PPSATPVIVEDDVLIGANAVILEGVRIGKGAVVAAGAVVTTDVEAGAVVAGSPAKVIK
                     MKDEKTADKTKLMEDLRNLD"
BASE COUNT         1316 a          503 c          491 g         1318 t
ORIGIN      
        1 ttataaaata ataaacaata taattccata taccaataaa taagataatc tttaagaaaa
       61 atgattatat ttaaaaggta aacataaaat ttataaactt ttagaataga aatctcaatc
      121 aattagatat tcaaattgat gaatatgaat acctaaatag attgagattt attatgtaca
      181 aaacttatcc taatatatct gacattttat aaagcccaga ttgcttacca attaaaaatt
      241 tagctgcaac tatagaaccg tttgcaaata cttcatcaga ttgagaatga tggcttaatg
      301 taagaacttc attatcacct gcaaatacaa catcatggtc gctgattata ttgccacctc
      361 ttatagagtg tattccaatt tcatttgatt ttcttttaca atctctacca tatctaccat
      421 gtgtattttc actttcaggc aagacttctc taattgcatt agctatcata gtagcagttc
      481 cactaggggc atcttctttt ctattgtgat gtttttctat gatttcaata tcaaaacctt
      541 ctaacatctt tgaagcatcc ttaactaatt ttattaatat attcactcca agagatgtat
      601 ttgatgataa taatatagga atgttttttg atgcttcttc tattttattt aagtcatttt
      661 catcatatcc agtagtagct aatactacag gtgtattatt ttttagagca tatgacaata
      721 ttggctctaa agtctcatga tgtgaaaagt ctataattac atcagttttt tcagctacat
      781 cagtcattgt tttgtaaagc tttgtatcac tatgatgacc tttttcatca gcagacctag
      841 ctacaccaca aaccaactct aattcattat ctttttttac acattctgct aaaactcttc
      901 ccattgttcc attatagcca ctaattataa ctttcaacat aaattcctcc tatgaaatta
      961 ataaaaattt gttatatttc tataagttta ttttatcact aatataattt atataaaata
     1021 atattagtga taataagctt acaatttatc ttacattaaa aaatttaagt ggatttttca
     1081 aaatatagat aaatttcttt ttcattgtat aaatgataaa aatatatttg acttcatacc
     1141 aaaaagagtg ccccatgaac taaaaagtta attttgaaat accatattca tatatcatat
     1201 gatttatttg gaaatcaata ttaatacatt aaaataacta aatacatgta tgcataaaga
     1261 tgtataaaaa atatataaac atatagtatt aattttaaat tcaacaattt aattgttaaa
     1321 agtgttatta ttaaattaga aatatcttaa cttaatatac tgagatggga gtgatagata
     1381 tgttaaaaga agaaaaaact tatcaagaga aagacgcaaa agtattcaat ggagtggcag
     1441 ctttgataat gattttatta tttttagtag tttcaatagg tatcatggtt tttgggatag
     1501 taaaacttga tagtggattt actggaatag gttcacttat gttaattttg ggacttgtat
     1561 ttatagtagt agattttatc ctattttttg ggctaaaaat gattaatcct aaagaagcta
     1621 tagttctagt tttgtttggt aactattatg gaactataaa aaaagaaggg tactattggg
     1681 tgaatccatt ttgttcagca ataaacccag cagtatcaag aattaatgta tcgaaatctt
     1741 catctgatga aaaggtagat atatcaacta attcaagtgg caaaaaagta tctttaaaaa
     1801 caatgactct taacaatgaa aagcagaaag tcaatgattt attgggaaat ccaattataa
     1861 taggagtggt tgtaatttgg aaggttatag atgcaacaaa ggcagtattt aatgtggata
     1921 attataatac attcttatct attcagtgtg attctactat tcgcaatgtt tcaagacttt
     1981 atccatatga tgtatctgaa gatggagatg aaaaatctct tcgtggtagt agtcaggaaa
     2041 tagcagatag attaaaagat gaattacaat caagggttga tattgcagga attgaagtgt
     2101 gtgaagtgag aattactcat ctttcttatg caccagagat tgcagcagca atgttacaac
     2161 gtcaacaagc agaggctata atagcagcac gtaaaaagat tgttgagggg gctgtaagta
     2221 tggtagagat ggcattgact aatttaagtg aaaataatgt tgtgactttg gacgaagaac
     2281 gtaaagcagc tatggtaagt aatctgttag ttgtgctttg tggcaataaa gatgcacaac
     2341 cagtagtaaa cagcagttct atttattaaa ttataaaaag tttaatagtt tattttattg
     2401 atatatagaa aatttagtag ttcattttat taaattatag aaagattaat ggtttgcttt
     2461 attgaattat aaaaagttta ataatttatt ctattgatat atagaaaatt tagtagttca
     2521 ttttattaaa ttatagaaag attaatggtt ttcactttat taaattataa aaagtttaat
     2581 agtttattac attgatatat tgaaaaattg aaggaaataa aaatacttgt cagcaagaaa
     2641 taaaaatgat ataagaatga ataagagaat tgtaaaaaaa taaaatgatt ataaataaaa
     2701 gataaaaata ttgtaaaaaa gagggtgcct ctggtgaatt aaattcacac agagacacct
     2761 ttttaattaa ttttttaaat tagtatatta ttgtttaatt aatagcatag tactatttaa
     2821 ttagtctaaa tttctaaggt cttccataag cttagttttg tcagccgttt tttcatcttt
     2881 catttttata actttagcag gagaaccagc aacaacggca ccagcttcta catcagtagt
     2941 tacaacagca ccagctgcaa caacagcacc tttaccgatt ctaacacctt caagaataac
     3001 tgcattagct cctattaaaa catcatcttc aactataaca ggagtagcag aaggtggctc
     3061 taaaacacca gcaacaacag caccagcacc taagtgaaca tttttaccaa gagttcctct
     3121 agctccaata acagcattca tatctaccat agaaccttca ccaataacag ctcctatatt
     3181 tataacagct cccatcatta caacagcatt tttttctata gtaaccatgt ctcttattat
     3241 tgcacctggc tcaattcttg catgttcact taaagtattt tttagaggaa tagcagaatt
     3301 tcttctatca tattctacat gagtatctgt tatatcattt ccatgtttat ctaatacttc
     3361 cattatatcc tcatagtcac ctacaaatat ataagaacca ttacttccaa ataccttaaa
     3421 tttatcagtt gattggaagt gtaaagagtt agtatttaca tataccttaa caggggtttt
     3481 ctttttaact tcttttatat accttgctat ttcataagca tcgtttaaat ttaccatttg
     3541 ttaattctcc ttgtatttca ttatatttct tttattatat acttatttgt caattttagt
     3601 atatacttac ttcttattat ttatattt
//
LOCUS       DAEQCW010000199         3474 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.200, whole genome shotgun sequence.
ACCESSION   DAEQCW010000199 DAEQCW010000000
VERSION     DAEQCW010000199.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3474)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3474)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3474
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.200"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     regulatory      22..115
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            198..683
                     /locus_tag="KRO40_003527"
     CDS             198..683
                     /locus_tag="KRO40_003527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBH2094320.1"
                     /translation="MISELMLKNFRKSSINFKTKIKLNLREKPDINSLKLKSIPEGKI
                     VKLKCVDGIWAEVESNYDKGWLLYKYLERLSNAKNNSNDTIKNRKKNYIGNIRTNGLS
                     LELRNDRTLESKVITTIPDGFKVEVCYSVGKWARVNINKNEKRYSGYVYNQYIEEHLS
                     L"
     gene            1038..1436
                     /locus_tag="KRO40_003528"
     CDS             1038..1436
                     /locus_tag="KRO40_003528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094321.1"
                     /translation="MNKKKKLIGIAISFLLIISIINPLQVEAEAIIESSVYISSIKEN
                     YTYDNTKFKTIKSKSRHKSRKYNKSKVKLKKRSIRTKKYGYQTINKYKRQNTRRHNIL
                     TKLILSIIVIFLVIVLVVLIFIKRKKKKFY"
     misc_binding    1872..2135
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2286..2837
                     /locus_tag="KRO40_003529"
     CDS             2286..2837
                     /locus_tag="KRO40_003529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan transporter"
                     /protein_id="HBH2094322.1"
                     /translation="MKTNTKKLTLNAILLAMGLLIHQITPAIGLPMKPDVPLAMLFVI
                     LVLNRDDYKTCLIAGIVTGIFTALTSSFPGGQIPNVIDKTLTANIVFLLMNISYNMPF
                     IKKLAKKTQDTVVVAIIMPIGTLVSGTIFLLAAQAIVGLPGASFTALFLAVVLPAVLI
                     NLVAGIFLFKIVSLSIRRVSYQA"
BASE COUNT         1512 a          303 c          480 g         1179 t
ORIGIN      
        1 attgttcaaa ttatgttatt attcagatat aggcaatatt agataaatct aatgacgcaa
       61 aactataggg actaaaatct ttatgtaata aaggtcatgt cagccagttg ccaaaaagat
      121 aataattctt tttgttaaaa gtatttttag agttatatat tttaataact taatatttgg
      181 caagaggagg gcttaagatg atatctgaat taatgttaaa aaattttcgt aaatctagca
      241 tcaattttaa gactaaaatt aaattgaatt taagagaaaa accagacata aatagtttga
      301 aattaaaaag tataccagaa ggtaaaattg ttaagttaaa gtgtgtagat ggaatatggg
      361 cagaagttga gagtaattat gacaaaggtt ggttacttta taaatattta gaaagattaa
      421 gtaatgctaa aaacaatagt aatgatacaa taaaaaatag aaaaaagaat tacataggaa
      481 atataagaac aaatggatta agtttagaac ttagaaatga tagaacatta gaatctaaag
      541 ttataactac aatccctgat ggttttaaag ttgaagtatg ttatagcgtt ggaaaatggg
      601 caagagttaa tatcaataaa aatgaaaaac gatattctgg atatgtatat aatcaataca
      661 tagaagagca tttaagttta taatacgata ctagcaagct ttaaatatat taataaatcg
      721 caaaaaagaa tcccattaat gggattcttt tttgtagaaa cattataaca gaactaaaga
      781 gaataaatta actaatttat ttttattata aagtaattat aaatggtaaa tttaattgaa
      841 agtagattta acttatactt tatacaccaa gtatcataaa ttaatactac tttgaaaaat
      901 cttaaaaaaa gtaaaagtta tgataataaa aataatatta aagataataa gatatataag
      961 aaacttgaaa aatttgtaat ttttagttat atatatatta taatgaacta gttaaaaatt
     1021 tttatgaggg ggaaaatatg aataagaaga aaaaattgat tgggatagct atatcttttc
     1081 tacttataat cagcattata aatccattac aagtagaagc agaagctatt attgagtcta
     1141 gtgtatacat ttcttcaata aaagagaatt atacatatga taatactaaa tttaaaacta
     1201 ttaaatctaa aagtagacat aaaagtagga aatataataa aagtaaagta aagttgaaaa
     1261 aacgaagtat aagaactaaa aagtatggat atcaaactat aaataaatat aaaagacaaa
     1321 acacaagaag acataatatc ctaacaaaat taatattgtc cataatagtc atatttttgg
     1381 ttatagtttt agtagtgcta atatttatta aaagaaagaa gaaaaaattt tactaaaaat
     1441 aattaaaaga atatcatttt tttaatcatt ggtatctatt taataatatg atgtaattaa
     1501 aatggagtaa tattctgttt caaaggaggc atataaatac aggaatgagt attaaatgat
     1561 ggttaattaa gtaaatttat tgataaatgt acttaattaa ctttgaagaa tttaattcct
     1621 catgaatcaa aatataaaat tacatcaaca gttattcaca aaattaatat aagaagaatt
     1681 agagtcaaag agcagactat tagaccatta aagtaattat tcatagaatt ttgtatatga
     1741 aaagaaatgt atagtataat ttactttttt tataaaaaat agattacaaa atatattttt
     1801 tataaaaagg tattgacatt ttttagaaaa aagaatatca ttattttaac aacaaaattc
     1861 aatacaataa attaaatcct atgacaagga agagtagtta aatttaggtt cagtatagag
     1921 agctgaggat ggtggaatct tagcaagaaa aaatttgatg aatggccctt agaggaataa
     1981 attgaaatca tagttttgag agtagacttt atcgtcagtc gcacgttata gcgaataagg
     2041 tatgtaagta cctgataatg agatgtatga aaattgaatt ttatattaat ttttatataa
     2101 tttaggtggc aacgcggata atctccgtcc tattagttta ggacggagtt ttttatttta
     2161 ctgaaaattt aaaagataga aggtggtgag aaagatgtta tgaatttcaa aagctaaaga
     2221 tgatgatata gtaggttggc aaaaaaataa attgaaaatt aaaaaaatag gaggaagtac
     2281 aaaaaatgaa aacaaataca aaaaaattaa ctttaaatgc aatactttta gcgatgggat
     2341 tattaataca tcaaatcaca ccagctatag gattaccaat gaagccagat gtaccactag
     2401 caatgttatt tgtaatattg gttttaaata gagatgatta taaaacttgt ttgatagcgg
     2461 gtatagtaac aggaatattt acagcactta catcaagttt tccgggaggt caaattccta
     2521 atgtaataga taaaactctt acagcaaata tagtattttt attaatgaat attagttata
     2581 atatgccttt tataaaaaaa ttagctaaga aaacacaaga tactgtagta gttgcaataa
     2641 taatgccaat aggaactctt gtaagtggaa ctatcttttt attagcagct caagctatag
     2701 ttggtcttcc aggggcttca tttacagctt tattcttagc agtagtatta ccagctgttt
     2761 taataaatct agttgcagga atatttttat tcaagattgt tagtctatca ataagaagag
     2821 ttagttatca agcttaaaca cgaaataata ttttacttta taaagcatta taataactaa
     2881 ataacataag aataaagtag attataacta ttttattctt atgttgttta aagatttggt
     2941 attatatatt tatttttaat aaaatattta tatagtacca attacactta atttaacaga
     3001 taaattatca tacctatata atattcttat atgtatctca tttgtagtta ttaaatataa
     3061 gatatattta attgactttt caagataaat ttttatatta atctcctctg atttctcatt
     3121 ttttgaatac actaaaattt ccaattaaat caattatata tttataaagt tttaaaaata
     3181 tagtaatgta tatatttttt gtgaaaaact tgcttaaatt tagccaaaaa aatagataat
     3241 tcatagtaaa aaataaagtt tagtaaaaaa ttttaataga actataaaag tctgttttag
     3301 taaaagattt aaaattctaa tattaagtga aattttgggt gaattaaata agcgaaacta
     3361 taatagaaat agaatatatg gaaaaataca tctctatgct taaaaaagaa aaataaatct
     3421 attaaaataa cataataaaa aaaatattaa gaataaaaat ataattataa gtat
//
LOCUS       DAEQCW010000200         3463 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.201, whole genome shotgun sequence.
ACCESSION   DAEQCW010000200 DAEQCW010000000
VERSION     DAEQCW010000200.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3463)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3463)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3463
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.201"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            101..1477
                     /locus_tag="KRO40_003530"
     CDS             101..1477
                     /locus_tag="KRO40_003530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk family potassium uptake protein"
                     /protein_id="HBH2094323.1"
                     /translation="MKTIVRRLILYADGMRPTQIMVSGFAAIIVIGALLLTLPIASQS
                     GESIGLLNALFTATSAVCVTGLVMVDTATYWSLFGQIVIITLIQIGGLGFMTVATMFS
                     LMARKKIQLRERLLIQESLNQADLSGLVRLTRFVLIITITIEGIGALVLSTVFIPQFG
                     LSKGIWYSVFHAISAFCNAGFDLMGSVSGPFTSLNSYVNNFTVSMTVCALIVLGGLGF
                     PVVLDIVRKRRFSKLNVHSKVVLFSTATLIFVGALFIFLIEFNQKATMADLPLKGKVL
                     SAIFQSVTARTAGFNTLDLATLRESSVFVMIILMFIGASPASTGGGIKTTTLAVLIIT
                     VRSFLSGKSDIEAFERRLAPSTIKKSLGIFVISISAVIFGTLIISITQPNFTLVQSAF
                     EVTSALATVGSSLAGTPNLNALGKIIIIIFMFMGRVGSLTLFMAILSGGRRKSQPIRY
                     AEGKIMVG"
     gene            1764..2435
                     /locus_tag="KRO40_003531"
     CDS             1764..2435
                     /locus_tag="KRO40_003531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HBH2094324.1"
                     /translation="MKQYIVIGCGRFGSSVASTMHLLGHQVMAIDKNEDSVQSISDKV
                     THSLIVDVTDEQALRSLGLGNFDVAVVAIGSDIRASIMATLIAKEMGVELIICKAKDE
                     LQAKVLYKIGADRVVFPERDMGVRVAHNLVSDNILDHIELDPEYSIVEIVTPNSWVGK
                     TLIELELRARYEITVLAIKTGKNINVTPSPDEELTAGSILVIIGQNTSITAITSGNKG
                     IIRRR"
     gene            2624..3421
                     /locus_tag="KRO40_003532"
     CDS             2624..3421
                     /locus_tag="KRO40_003532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HBH2094325.1"
                     /translation="MITNINSKDNEKLKYTRALLKSKNRNKESKFIIEGYRIVMLALE
                     CMANLDYVFINEEFENKKEHVKLLEDLDKKNTKIYKTTNKNFKELVDTENTQGIIGVV
                     SFKKKKLSESINKKDKFVLILDRIQDPGNMGTIIRTADSAGVDAIIALKGCVDIYNPK
                     VIRSTMGSIFDMNIIDASQDETVDMLKSLDFNIVSSYLNTENFYDKIDYGSKVALVIG
                     NEANGINEELVSKSDILVKIPIYGKAESLNAAISSAILMYEIKKYLI"
BASE COUNT         1296 a          393 c          656 g         1118 t
ORIGIN      
        1 ttatactata atagaataat aatttagagg aaagctctaa aaataaacaa attaagggtc
       61 ttaacagtag tgattttatg ttaaggaggt ataaagaaag ttgaaaacaa tagttagaag
      121 acttattctc tacgcagatg gaatgcgtcc tactcaaata atggtatctg ggtttgctgc
      181 aattattgta atcggagcat tgttgttaac actcccgata gcgtcgcaga gtggagagag
      241 tataggctta ttaaatgctc tatttacggc tacttcagcg gtttgtgtta ctggtctagt
      301 tatggtagat acagcaactt attggagttt atttggacag atagttataa taacattgat
      361 acaaattggt ggtcttggat ttatgaccgt agccacaatg ttttcactta tggcacgaaa
      421 aaaaatacaa ctaagagaaa gattattaat acaagagtca ttaaatcaag ctgatttatc
      481 gggacttgta agacttacaa gatttgtatt aataataacc ataacaatag agggaatagg
      541 tgcactggtt ttatcaactg tctttattcc acaatttggt ttgtctaaag ggatatggta
      601 tagtgtattt cacgcaatat cagcgttttg taatgccgga tttgacttga tgggcagtgt
      661 aagtggccca tttacatcgt taaattctta tgtaaacaac tttacagtat caatgactgt
      721 ttgcgcactt atagtgcttg gagggctagg attccctgtt gtacttgata ttgtaagaaa
      781 aagaagattt tcaaaattaa atgtgcattc taaggttgta ttgttttcaa ctgctacact
      841 tatttttgtg ggtgcattat ttatttttct tatagaattt aatcaaaaag ctactatggc
      901 ggacttgcct ttaaagggaa aagtactatc agcaatattt caatcagtaa cagcaagaac
      961 tgctggtttt aatacacttg atttagctac tttacgagaa agtagtgtat ttgtaatgat
     1021 aattttgatg tttattggag catcacctgc atcaactggt gggggtataa aaacaacaac
     1081 actagctgtt ttaatcatta cagttagaag ttttctatca ggaaaatcag atatagaagc
     1141 ttttgaaaga agattagctc catcaactat aaaaaaatct cttggtatat ttgtaattag
     1201 tatatcagca gttatttttg gaacattgat tatttcaata actcagccta attttacatt
     1261 agttcaatca gcttttgagg ttacatcagc acttgctaca gttggttcaa gtttagctgg
     1321 aactccaaac ttaaatgctt taggtaagat tataataata atttttatgt ttatgggtag
     1381 agttggttct cttactttat ttatggctat actttctggt ggtagaagaa agagtcaacc
     1441 aatcagatat gcagaaggta aaattatggt tggttaagtt accaaggagt agtataaatt
     1501 tataatggat ttagagtagc actgtaaatc tgttgataaa ataaatgagc ctagatgtaa
     1561 ttatatgaag aaataaaatc aactaacgaa caaaattaat taatgaaata aaaaaacagg
     1621 gaaataaaat acaaataaaa aggtaaatca aaattaaatt aatctgtgta tataaaatta
     1681 tatattgtgt ataagttttg tatgtgtaaa caattaattt aagagatatt atataaattg
     1741 tgtattaggg aggaagtttc gagatgaagc aatatatagt cattgggtgt gggagatttg
     1801 gaagttcagt tgcgtctact atgcatcttt taggacatca agtaatggca atagacaaaa
     1861 atgaagattc agttcaaagt atatctgaca aggtaaccca ttcacttata gtggatgtta
     1921 ctgatgagca agcgttaagg tcattaggtt taggtaactt tgatgtagca gtagttgcaa
     1981 taggttctga tataagggca tctataatgg cgactcttat agccaaagaa atgggtgtag
     2041 agttgataat atgtaaggca aaggatgaat tacaagctaa agttctttat aaaattggtg
     2101 cagatagagt tgtatttcca gaaagagata tgggagtaag agttgcacac aatttagttt
     2161 cggataatat attagaccat attgaacttg acccagagta ttcaattgtt gaaatcgtaa
     2221 ctccaaatag ttgggttggc aagacactta tagagcttga attaagagct agatatgaga
     2281 taactgtact tgctataaaa acaggtaaaa atataaatgt tacaccttct ccagatgagg
     2341 aacttacagc cggaagtatc ctagttataa tcggtcaaaa tactagtata acagcgataa
     2401 catctggaaa taaggggata attagaagaa gataatttac tatttaatat atatttaatt
     2461 gcaatgaaag tagatagtat catataatta tgaatagtta tatgatacta tttttttaat
     2521 cgaaggtagt atttatttgt aagattagat aaagagaagt taaattaaaa gtaaggaggc
     2581 tgtgctaata taaaaattta taagttatta gcatttagat aaaatgatta caaatataaa
     2641 cagtaaggat aatgaaaagt taaagtatac aagagcacta ttaaaatcaa agaataggaa
     2701 taaagagtca aagttcataa tagagggata cagaatagta atgcttgcac ttgaatgtat
     2761 ggcaaacctt gattatgtat ttatcaatga agaatttgaa aataagaaag aacatgtaaa
     2821 actattagaa gatttggata aaaaaaacac aaagatatac aagactacta ataaaaactt
     2881 taaagaatta gtggatacag aaaatactca aggaataata ggtgtagttt catttaagaa
     2941 aaaaaaatta agtgaaagta taaataaaaa agataaattt gtattgattt tagacagaat
     3001 acaagaccca ggaaatatgg ggactataat aaggactgct gattctgctg gagtagatgc
     3061 cataatagca ctaaagggat gtgtcgatat atacaaccca aaagtaatta ggtctactat
     3121 gggttctatt tttgatatga atataattga tgcttcacaa gatgaaactg tggacatgct
     3181 taaatcattg gattttaata tagtttcaag ttacttaaat acagaaaatt tttatgacaa
     3241 aatagattat ggctcaaaag tagcattggt gataggaaac gaagcaaatg gaataaatga
     3301 agaacttgta tcaaagtctg atattttggt taagatacct atatatggta aagccgagtc
     3361 gttaaatgct gcgataagct ctgctatact gatgtatgaa ataaaaaaat acttaattta
     3421 atgtattgta ataaatataa tgtcatgtta taatcttgaa tta
//
LOCUS       DAEQCW010000201         3448 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.202, whole genome shotgun sequence.
ACCESSION   DAEQCW010000201 DAEQCW010000000
VERSION     DAEQCW010000201.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3448)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.202"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(108..1675)
                     /locus_tag="KRO40_003533"
                     /pseudo
     CDS             complement(108..1675)
                     /locus_tag="KRO40_003533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021426623.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iota toxin protein Ib"
     gene            complement(2011..2193)
                     /locus_tag="KRO40_003534"
     CDS             complement(2011..2193)
                     /locus_tag="KRO40_003534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094326.1"
                     /translation="MKKFRKHKSISNCISILLILYLTLGSLLPNNIYAQDLQSYSGKV
                     CNTTYKAPIERSEGFF"
     gene            complement(2582..3328)
                     /gene="cdtR"
                     /locus_tag="KRO40_003535"
     CDS             complement(2582..3328)
                     /gene="cdtR"
                     /locus_tag="KRO40_003535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family response regulator CdtR"
                     /protein_id="HBH2094327.1"
                     /translation="MDILIFDNDVCFGMKLKEKINNILIKEGFDNDVVRLYHNANLLL
                     KELTEKNKVRIYFIVVDAKYKISNELCDGLWIAQKIRESDYISPIIFLTNHIEMILGI
                     FDYRLEVMDFILKHDMEIAESKIKACIKIAHKRYIKEKNYRSNFFTIYSDFSLWKISF
                     DEVIYFETSTIPHKIKLVTTSRIFEFYKSLKSLPDLDACFIRVHKSFVVNKYHIVSLD
                     LKKNNIKMSNGHICRISNTYRNILKNIIKT"
BASE COUNT         1149 a          450 c          377 g         1472 t
ORIGIN      
        1 agaagaagat aatatttaaa taaaaaatac cttataaagt taatttttta atactttata
       61 aggtaaatac atattgtatt gtggggataa atttaaatca tttgatacta atcaacacta
      121 agaaccaata actctctatc atcttgagta attgtatata ttcttaattt cttgtatgtc
      181 ataatatttt ctccacctgt aaaataactc ctaagattaa cacaatcagt tttaggttga
      241 tttgtatctc ctaaataatt acgcaattct ttatctttag tttcaatatc tttaaatcca
      301 aaatattgta aagtagcttc aactctatat ttttggacat aatcgagagc ttctttatta
      361 gtttatgttg gtgtaaaata cataccattt atataagcct ttattgtact tggattaaat
      421 ttaaaatctg cagaatatat tttatgtgta actattattt cttgaacagt tggaatttta
      481 acttctggtt catcaagtat ttcaggagta ctatttagct ctgtaataga taagttatct
      541 aagtatattg tatcactatc aattaatgct atatttatat tagaagaatc tttttcagta
      601 gtttcaaatt cataactaaa ttttgtatat ccttgttcta gtaccaaata atccgttttt
      661 tcttctttta cttttatatt tacaattatt gaattatatg ttaaaggatt ttttgaattt
      721 tactaaaaac ataacgttta taaggtttta gttcagacat aggtatttta atcttcgtct
      781 caccatttaa tctatttgct gagcctttta aaccatcttg atttgtagta ttaacattac
      841 tccatatact agggtaatta ttgtaatcat caaaattagt aaagtaagtt ggtgttttta
      901 taagtatatt cattcctctt tcaagtttaa cattacatat ttgtttatca gacaaagttt
      961 ttaaactgtc tttaatctta ttgcctatat tatcatcaaa tatgagttca acacaacttt
     1021 catctattgg tatattatta aaatataaca aaccatcttt tttagtagtg ccaaaagttt
     1081 tttcaattgc ttctccaatt gtaagttcag gtgttttatc ttctgggacc tgtaaacttt
     1141 tagcagtaat tcttcttttg taagattcat tttctgtatc taatataata gatacagaaa
     1201 tactgtcaat ttgacctata tcgtcttacc aactatttca ttctgttact atttgtccag
     1261 aaccattttt tgtaccaaaa tttccactta cttgtgttgt ttctaattta atttgctttc
     1321 catcatctaa tttttttaat taattataat ttataggaat cagtctagaa ctaaattgat
     1381 acattgtgtt aagagccata ggtgaaaatc cttttttgag ataagtattt ccaggagata
     1441 gattattgcc aatttgattt tcttgtgctt tgatagttga taatgcatct ccatctaaca
     1501 ctaaatttgt tgttggtgtc actttgtaca taggtgcagt acctgtgttg tagtatctaa
     1561 tatttgcatt tatatatgca gattctcctt tgtttatact taatccagta tttcatgatt
     1621 atccattgct attttgaaca gcagttgaat tatctgttgt atggtaataa tttgtcttgt
     1681 atagtttctt taaactcatt aaatttttct aatgaaattt cgttttgatt ttttgttctt
     1741 attactttat taaatgcaaa tttttctgga gattcaaaat aatatacata cataggttta
     1801 tctattttat tttttgatat agcatttcga agttctctat attctttttc tcaagaattt
     1861 gcttctattt gataatcata aaaataattt cttgtctgag aatatttgct tatctctata
     1921 gaatcttttt tatatgatcc taatacttct ttttcagatt tttcaagttt ttgatctttt
     1981 ctttctcatt ctttagcctt ttctttatct ttaaaaaaat ccttctgatc tttctatagg
     2041 agccttgtaa gtagtattac aaacttttcc actatagctt tgtaaatctt gtgcataaat
     2101 gttattaggt aacaaactac ctaaagttag atataatatc aacaatatag atatacaatt
     2161 actaatactt ttatgtttcc taaatttttt catttattct ccctacaaat attagtttag
     2221 ttaacttttg aattttaatt tatttagatt atataatcta aataagaatt ttttatataa
     2281 atttcataaa atatgtaggt atatatcata aaaatatgta tttatatgat atgtcagtac
     2341 aaaataacaa ctgaatattt taaagagact atttcgtact tttatgattt aatgagctat
     2401 cttatcgaat cataatctag gaacaattgt tataatatct aatagtagtt atatatgata
     2461 tagtcagtat gtgttttttc acaatatgat tattatatag aggattctta gggattactc
     2521 tttttgtata aaaaagagat ggttcaaatt tttatcttga gacatctcct ttttctattt
     2581 attatgtttt aataatattc tttaaaatat ttctatatgt attagatata cgacatatat
     2641 ggccattact cattttaata ttatttttct ttaggtcgag agaaacaata tgatatttat
     2701 taactacaaa agatttatgt acacggataa agcatgcatc taaatctggt aaagacttta
     2761 aacttttata gaattcaaat attctagaag tagtcactaa ttttatttta tgtggaatag
     2821 tgcttgtttc aaaatatata acttcatcaa atgaaatttt ccatagtgag aaatctgaat
     2881 agatagtaaa aaaattagag cgataatttt tttctttaat gtatcttttg tgagcaattt
     2941 taatacaagc ttttatttta ctttcagcaa tttccatatc atgttttagt ataaagtcca
     3001 taacttctaa cctataatcg aagatcccta aaatcatttc tatatgattt gtaagaaata
     3061 tgattggact aatataatct gattctctaa ttttttgtgc tatccataat ccatcacata
     3121 attcattact tatcttatat tttgcgtcta caactataaa atatattctt actttatttt
     3181 tttcagtaag ctcttttaat aacaaatttg cattatgata taatcttaca acatcattat
     3241 caaaaccttc ttttattaaa atattattta ttttttcttt tagtttcatt ccaaaacaaa
     3301 catcattatc aaagattaat atatccacta aataccctcc tataaaaaat tcaaaagtaa
     3361 aaaaacaaaa gtattttata gaaaatacat aaaataacac taggagataa ataagattaa
     3421 ggatagttag aattaaggta tatttatg
//
LOCUS       DAEQCW010000202         3286 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.203, whole genome shotgun sequence.
ACCESSION   DAEQCW010000202 DAEQCW010000000
VERSION     DAEQCW010000202.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3286)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.203"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(381..1103)
                     /locus_tag="KRO40_003536"
     CDS             complement(381..1103)
                     /locus_tag="KRO40_003536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004398740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBH2094328.1"
                     /translation="MITIKNLSKSFGDLNVLKNIDLEIAKGEIMVIVGPSGSGKSTLL
                     RCMNLLEIPTGGEIIFEGKNLVDKKTNIDEVRQNIGMVFQNFNLFPHKTILDNITLAP
                     IKLKKMTKEEAEKKAEILLSRVGLLDKKDSYPSQLSGGQKQRIAIARALAMEPDMMLF
                     DEPTSALDPEMVNEVLDVIKELAKEGMTMAIVTHEMGFAKEVADRVIFIDGGSILEDN
                     TPEEVFGNPKHERTKAFLAKVL"
     gene            complement(1162..1839)
                     /locus_tag="KRO40_003537"
     CDS             complement(1162..1839)
                     /locus_tag="KRO40_003537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBH2094329.1"
                     /translation="MSLDFSFLSRFGTSFLEGTGVTVSISLVALCFGFIIGIIICMAK
                     ISKSKVLRAISSIYIEVLRGTPLLVQIYIVWFGLPQLGIRFPMLFGIPSEFIASAFAL
                     SVNSGAYVAEILRSGIQSVDNGQMEASRSLGLNYWSTMRYIIIPQAIKNILPSLANEF
                     ITLVKESSIISVIGVVEIMRTADIVKNAAFRALEPLIVAAAIYFVITFTLSRLVGLLE
                     KKLSVSN"
     gene            complement(1867..2682)
                     /locus_tag="KRO40_003538"
     CDS             complement(1867..2682)
                     /locus_tag="KRO40_003538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBH2094330.1"
                     /translation="MKVFKKLLSLGLVLGLTLSLVGCSGGGEKTKLEQIKDNGKLVVG
                     TSAEFPPFEFHKVVDGKDSIKGFDIMLAEEFAKELGVKVEIKDMSFDGLIGALNADQV
                     DIVLAGMSPTPEREKSVDFSELYYLSRNAVIVKDADIDKVKTEDDLKKLRVGVQAGSI
                     QEEYVVNTLKMTTTKSLKAIPDLITELKNGNIDAVVTNEAVSLINVKKYDGIKMANTE
                     VGKDVTEGMAAAIKKSDNNKDFIELLNKKIKELQDGKKIEEFLNEASTEAASN"
     misc_binding    complement(2908..3118)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
BASE COUNT         1025 a          608 c          335 g         1318 t
ORIGIN      
        1 tatttttact ataaaagtta aatttataag cttacttgtt ataaaaataa cttttataat
       61 ttatttcaaa aaaaatattg atttttgtgt cgcattttgt tataataaat taaggttatc
      121 cccctggtaa ccctagttag ttaatatatc tattcccaat accctttcat aaggatatat
      181 tttatattta ttaaaaatcg gattagtaac ggaaattaat tcggtggaaa aaaagagctt
      241 accccgagct cttttttttc tgcaaaaaat cgtaaaaata aagttaatat taatataact
      301 ttaattttaa aattaatatt aaccatcact aaaaaaggat gtattgaatt tctaatatca
      361 ataacatcct ttttatataa ttatagcact tttgctaaaa atgcttttgt tctttcatgt
      421 tttggatttc cgaaaacttc ttctggagta ttatcttcaa gtatacttcc tccatctata
      481 aaaataactc tatctgcaac ttccttagca aatcccatct catgagttac aattgccatt
      541 gtcatacctt ctttagcaag ttcttttata acatccaaaa cttcgtttac catttctggg
      601 tcaagagcag atgttggctc atcaaacaac atcatatctg gttccatagc aagtgctcta
      661 gctattgcta ttctttgctt ttgtcctcca gataattgtg atggatatga atctttttta
      721 tctaaaagac caactctact caacaaaatt tctgcttttt tttctgcttc ttccttagtc
      781 atctttttta atttaattgg tgctaatgtt atattatcta aaatagtctt atgtgggaat
      841 aaattaaagt tctgaaacac catacctata ttttgtctaa cctcatcaat attagttttt
      901 ttatcgacca aattttttcc ttcaaatatt atttctccac ctgtaggtat ttctagtaaa
      961 ttcatacatc taagaagtgt acttttacca gaaccacttg gacctactat aaccattatt
     1021 tcgcctttag cgatttctaa gtctatattt tttaatacat ttaaatctcc aaaagattta
     1081 cttaaatttt ttattgtaat catattatca ctttcctttt tactattcta tgttttccct
     1141 aaatgctaaa catgctctca tctagttaga cacagatagt ttcttttcta ataatccaac
     1201 taatcttgat agagtaaatg ttataacaaa gtaaattgct gctgctacta ttaatggctc
     1261 taatgctcta aatgctgcat tttttactat atcagcagta cgcattatct caacaactcc
     1321 tattacagat attattgaag attcttttac aagtgtaata aactcatttg ctaatgaagg
     1381 taatatattt tttatagctt gaggtattat tatatatctc atagttgacc aataatttaa
     1441 tcctaatgat ctacttgctt ccatttgtcc attatcaact gattgtatac ctgatctaag
     1501 tatctctgcc acgtatgcac cagagtttac tgataatgca aatgcactag ctataaattc
     1561 acttggtata ccaaacaaca tagggaatct tattcctaat tgaggtaaac caaaccatac
     1621 tatatatatc tgtactaata atggtgtccc tcttaaaacc tcaatataga ttgatgatat
     1681 tgctcttaat actttgctct ttgatatttt tgccatacag ataattatac ctattataaa
     1741 tccaaagcat aatgccacaa gagaaattga tactgtcaca cctgttcctt ccaaaaaaga
     1801 agtcccaaat ctacttaaaa aactaaaatc taaactcata atttcatctc ccacataact
     1861 ttcttactaa tttgaagcag cttcagtaga tgcttcattt aaaaattctt ctatcttctt
     1921 gccatcttgt aattctttta tctttttgtt taataattct ataaaatctt tgttattgtc
     1981 agattttttg attgctgctg ccataccttc tgttacatct ttcccaactt cagtatttgc
     2041 catttttatt ccatcatatt ttttaacatt tattaaagaa actgcttcat tagtaacaac
     2101 tgcatctatg tttccatttt ttaattctgt aattaaatca ggtattgctt tcaaagattt
     2161 tgtagttgtc atttttaaag tgttaactac atattcttct tggatacttc ctgcttgaac
     2221 tccaactcta agtttcttta aatcatcttc agtttttact ttgtctatat ctgcatcttt
     2281 aactataact gcatttctac ttaaataata taattctgaa aaatcaacac tcttttctct
     2341 ctctggtgtt ggagacatac ctgcaagaac aatatcaact tggtctgcat ttaaagcacc
     2401 tattaatcca tcaaatgaca tatccttaat ttcaaccttt acaccaagct cttttgcaaa
     2461 ttcttcagcc aacattatat cgaatccttt tattgaatct tttccatcta ctaccttatg
     2521 aaattcaaat ggaggaaatt ctgcactagt accaacaact aattttccat tgtcttttat
     2581 ttgttctaac tttgtttttt ctcctccacc actacatcct actagcgata atgtcaatcc
     2641 taatactaat cctaaactta ataatttttt aaatactttc attttaacta cccctctctt
     2701 ttaattataa tttccctcag attttaatac ttaaatgttt cgagttacaa aaaaagtctc
     2761 tcagtcttta atgactaaga gacgacttta ccgcgttacc actcttattg ataaatactt
     2821 atattacttt caaaatttgt gactgttagc atttaagctg tatggatatt tttattttta
     2881 aatcaaaaaa gtcccttagc tttacagcta agagacgaat tatatccgcg ttaccactct
     2941 ttttgataag taagtactta tcctctcaat cccttaaggc gggtaaacca attatcatac
     3001 taaagtttct gataatctcc tccagagctc tcttcacata gacttcattg ctaggcttac
     3061 accaacccct aactcgctgt aaatccatat atgctacttt ctctatcatt ggatttgttt
     3121 ccttaaattg ttaatacaat tgtacttcct tataatattt ttgtcaataa gttttttatt
     3181 tttttaataa tttttacttg taaattatct aaatactact gtttatattt attgatatta
     3241 gttttgtaat tataaatagt atatttcata tttttagcta tttctt
//
LOCUS       DAEQCW010000203         3260 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.204, whole genome shotgun sequence.
ACCESSION   DAEQCW010000203 DAEQCW010000000
VERSION     DAEQCW010000203.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3260)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3260)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3260
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.204"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(406..627)
                     /locus_tag="KRO40_003539"
     CDS             complement(406..627)
                     /locus_tag="KRO40_003539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1659 domain-containing protein"
                     /protein_id="HBH2094331.1"
                     /translation="MEVVSTKNLSSIKLKLDAGFDDKGKAVVKSKSFANVKAEALNED
                     VYAVAEAIASLQENPIVDILKLDSTSLSK"
     gene            1207..1464
                     /locus_tag="KRO40_003540"
     CDS             1207..1464
                     /locus_tag="KRO40_003540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH2094332.1"
                     /translation="MKIKVEDIPVQFHAMVEIIGIDKFIEVAKLYGGTNTYIPTYKGL
                     FRYARNRDIVKQFNGVNHNELAIRYNMCVSNIKRILNENNV"
     gene            1933..3171
                     /locus_tag="KRO40_003541"
     CDS             1933..3171
                     /locus_tag="KRO40_003541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBH2094333.1"
                     /translation="MNKGFYKLNSVVLNFDIKNDVNKIRFNHYIMRKENIQRLQGTLP
                     NGQFYMTVRRAATDLQLSISTISRLVKEFLDLGIIRLVSKGVKGNRSVYSYVSIEFNG
                     SLFDDSKYMELDCVCNDEFIDNSGIEFDCDSKDNSFNGDINVETVHCINEYLSDDDVE
                     HNYNNFHNKDTIKDKAISNISTIKKYIDESFDKNKSENSNLQQESINFNFNDTCNEID
                     KRTNNSIENNQNKRPMRLSDISVLSDKGMTNKKNYFNHNHGIQKGTKSVTKKKESLNK
                     FNKKNIQQSIINMLNKKSGKNFKIDSPISIKLINERLKEGYVLEDFYKVIEVKVAKWK
                     NTIMEMYIRPETLFSYKFESYVNENISMKSQSNVHPCKEGNSNDSSNYIHSDYTTYDG
                     SVRERKKYENVRYWNPICEI"
BASE COUNT         1325 a          292 c          493 g         1150 t
ORIGIN      
        1 tgttttgctt gttagtatta gtatttcaat tgtcaatatt agtgttttgc ttgttagtat
       61 taatatttca attgtcaata ttagtgtttt gcttgttagt atcagtgttt caattgtcaa
      121 tattagtatt ttaattgttg actctagtta ttgctgatat agaaaatatt taatttattt
      181 caattaatta gattaaagta gggtagcatc taaaatagct aacatgttta agttgaaata
      241 cgtttaatat attaattttt caaagcatta atatattaaa gttataatca aaattgaagt
      301 tataatctgc caaatctata gcgtattaag tgcgttatat aacttaatct tttatataaa
      361 gagttaattt ttttaatttg taaagcagag tacgtttaaa aggtactatt tagataatga
      421 tgtactatct aattttaaaa tatctacaat agggttctct tgaagacttg ctattgcttc
      481 tgcaacagca taaacatctt catttaatgc ctctgctttt acatttgcaa atgatttact
      541 tttaacaact gccttaccct tatcatcaaa accagcatcc aattttagtt ttatactaga
      601 taaatttttt gttgaaacaa cttccataaa attacctcct aaaaatttaa tttcaaagat
      661 ttgtcgactt tctttgttag ctataatact atcatctaag ataatatcgg agttaaacag
      721 taatttctaa agattttttg tgtaaatttt tataggaaaa attttacttt tttgctgatg
      781 aaaaagttta caagttattt gtgaagatat gttcttagtg ttttgaaata gtatttgtat
      841 atattcatgc ttagttgaga tagttttgta tggattttca tatgtgtaga gttaaatgtt
      901 aggtactaaa gtttatgtta aattaaatgt taaagcttat gttaaaaatt ttattaaatt
      961 taatctgtaa ataaaaaagt taaaagtcca atattaacat tttactttta aaccattaaa
     1021 atctttatta aagctaacaa agttataagt tatgagaaat tttattaaag ttaatacaaa
     1081 aattaatttt aaagctaaga aattttttat tagattcaat aaaactaata aatatagttt
     1141 agtcaataat gtattaaata aaaactttgt taagtctata aaaatatctt aaaggaggtg
     1201 taacttatga agataaaagt ggaggatata ccagttcaat ttcatgcaat ggtagaaata
     1261 attggaattg ataagtttat agaggttgcc aagttgtatg gaggaacaaa tacttatata
     1321 cctacgtata aggggctttt tagatatgct agaaataggg atatagtaaa acaatttaat
     1381 ggagtcaacc acaatgaatt ggctattaga tataatatgt gtgtaagcaa tattaagcga
     1441 atactcaatg aaaataatgt ttaaatataa taaaataatg tttaaacata atgaaaatag
     1501 ccttgttaaa cgtaagagta aagacaaaga agatgtttta taaagttttt ttagacaaat
     1561 taactaaatt tactacttat taatttaaat acattgtata ttctataaaa aaatttgtta
     1621 aatactggag atatattgag aatacaaaga aaatggtcga aaatatttgt tggctaaaaa
     1681 atagataaaa tgatacaatt gcttgtataa aggggaaaaa taaacaaata aactatataa
     1741 ataaagaaat agcaattaat atgacataat atatttataa aattaagaat ataaatagat
     1801 attttaaggt attagttgtt aaattaggaa atattaaaaa aaatatatat ttatatttaa
     1861 actattttgt tatttatata aaaatactta tctagttact agcaattatt agtagaaatg
     1921 ggggaaatag agatgaataa gggattttac aaattaaatt cagtggtatt gaactttgat
     1981 attaagaatg atgttaacaa gataagattt aatcattata taatgagaaa agaaaacata
     2041 caaagacttc aaggaactct gccaaacgga caattttata tgacagtgag aagagctgct
     2101 acagatttac aactttctat ttctactata agtaggcttg taaaagagtt tttggattta
     2161 gggataataa gattagtgtc taagggtgta aaaggtaatc gttctgtata tagttacgta
     2221 agtatagagt ttaatggaag tttatttgat gatagtaaat atatggaact tgactgtgta
     2281 tgtaatgatg aatttattga taatagtggc atagagtttg attgtgatag caaagataat
     2341 tcttttaatg gagatataaa tgtagaaact gtgcattgca ttaatgagta tttgtctgat
     2401 gatgatgtag agcataatta taacaatttc cataataaag atactataaa ggataaagcc
     2461 atttctaata ttagcactat caaaaaatat attgatgaat cttttgataa aaataaatca
     2521 gaaaattcta acttacaaca ggagtcaata aatttcaact ttaatgatac atgcaatgaa
     2581 atagataaaa gaacgaataa tagtatagaa aataatcaaa ataaaaggcc tatgagattg
     2641 agtgacatca gtgttttaag tgataaaggt atgacaaata aaaagaatta ctttaatcat
     2701 aatcatggta tacaaaaagg gactaaatct gtaacaaaga aaaaagaatc cttaaataaa
     2761 tttaataaaa aaaatataca gcaaagcatt ataaatatgc taaataaaaa atcaggtaag
     2821 aattttaaaa tcgattctcc aataagcata aaacttatca atgaaaggct aaaggaaggc
     2881 tatgtcttag aagatttcta caaagttatt gaggtaaaag tggctaagtg gaaaaatacc
     2941 ataatggaga tgtatataag accagaaacc ttgtttagct ataagtttga atcctatgta
     3001 aatgaaaaca tatctatgaa aagtcaaagt aatgttcacc catgtaaaga aggcaatagt
     3061 aatgatagca gtaattatat acattctgat tatacaacat atgatggcag tgtgcgtgag
     3121 agaaaaaaat atgagaatgt aagatactgg aatcctatat gtgagattta attagtttaa
     3181 gaatgtattt atgataaata agatattaat agagaatagt gagctatagc aaatgatata
     3241 tcaatagttg gtagtaagtt
//
LOCUS       DAEQCW010000204         3249 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.205, whole genome shotgun sequence.
ACCESSION   DAEQCW010000204 DAEQCW010000000
VERSION     DAEQCW010000204.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3249)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.205"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(81..833)
                     /locus_tag="KRO40_003542"
     CDS             complement(81..833)
                     /locus_tag="KRO40_003542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBH2094334.1"
                     /translation="MFSVIFLCIGGFLAAFVDSIAGGGGLISMPVLMAIGVPVHLAIG
                     TNKFAASAGCISSAYRYAKSGKINNDLLKKLVPFTIIGSVLGVRCVLSISEEILNVLV
                     VVMILIVAIYTFISKNLGQEDNFEAVNKKNLRLGMLMALIMGFYDGFFGPGTGTFLTF
                     GFIKIYGYDFLHASANTKILNLTSNITSLLLFMINGQVDYKIAIVFALVMIMGAYVGA
                     KVAIKKGSKMIKPIFLVMALFMVVKLVYQTLV"
     gene            complement(892..2547)
                     /locus_tag="KRO40_003543"
     CDS             complement(892..2547)
                     /locus_tag="KRO40_003543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2094335.1"
                     /translation="MVDFSESNNEVQKFDWGEVMWIHEPSKTQFNRLSAGIVRFFPGN
                     CQEKHFHLSEEQLLYVIQGEGIQIIDGKKVNIKETSIVYCPPYSEHEIINTGKIDLVI
                     LITYVPHKFSSLRQIPIVFSENNIQELVNVNIIENLANQISNILKLRISVYDLKYKEI
                     FETKKENKFCDICKNIKQCTKKLVKSINNDNFEKVYHCEYGVSSLEIPIVLEENIVGY
                     IECGNFIVYKSIDIDKNLSELSSSSGIDIKYINKIYNEFPLNPKSRLYVLKENLLMMS
                     EFIQEIAKRNFFENQLSIKDEEILKSRKENIRLEEALKKANSRLLEEEYIINPIDMFN
                     NSSKEYPFELELYIEKEIKNMNLEGVYNLIDTNKLRYNDVRDTIQEMIFVLSRTVLRD
                     LEDLKLISYLRNKYNKKISLVNSDEDLWNVLFEFSKECIDKNRAFWRKDKGNLIENIN
                     EYIKKYYKENINLNSISDVFFISPNYLSSIFNERNKVSITEYINLLRIEESKKYLLDR
                     SMSISDICKKVGFNNSSYFSQIFKKFNSITPNEYRKNMLDNKY"
BASE COUNT         1126 a          530 c          261 g         1332 t
ORIGIN      
        1 attagaattt ttataaagct atatgattag attaaatata aaagctttac aattacttat
       61 aaatttaaaa agtctataag ctaaactaat gtttgatata ccaattttac gaccataaat
      121 aatgccatta ctaaaaatat tggttttatc atctttgaac ctttctttat agcaacttta
      181 gcacctacat aagctcccat tatcatcact aatgcaaaca ctatagcaat tttataatct
      241 acttgaccat ttatcatgaa taataacaat gaagttatat tacttgttaa gtttaatatt
      301 tttgtatttg cagaagcatg taaaaaatca tatccatata tttttataaa tccaaaggtc
      361 aaaaaagttc ctgtacctgg accaaaaaaa ccatcataaa aacccattat aagagccata
      421 agcatcccta gtcttaaatt tttcttatta acagcttcaa aattatcttc ttgacctaaa
      481 tttttagaaa taaaggtgta aatagccact attaaaatca taaccacaac caaaacattt
      541 aatatctctt cacttattga taatacacat ctcacaccta gaacactacc aataatagta
      601 aatggtacta atttttttaa aaggtcgtta ttaatttttc cagactttgc atatctatag
      661 gcactactta tacatcctgc tgatgctgca aatttatttg taccaatggc aagatgtact
      721 ggcactccaa ttgccataag aacaggcatg cttataagtc ctcctcctcc tgctatagaa
      781 tctacaaaag cagctaaaaa cccccctata cataaaaaaa taactgaaaa cataaaattc
      841 ctccatcatt ctctttcaat ttttcttaca atatatatta tataatctta tttaatactt
      901 attatccagc atattctttc tatattcatt tggagttata ctattaaact tcttaaatat
      961 ttgtgaaaaa taactactgt tattaaaacc tactttctta caaatatcac taatactcat
     1021 gcttctatct aacagatatt ttttagattc ttctatccta agaagattta tatactcagt
     1081 tattgaaact ttatttcttt cattaaaaat agaactcaaa taatttggac ttataaaaaa
     1141 aacatctgat atactattca aatttatatt ttctttataa tattttttta tatattcgtt
     1201 tatattttca attagatttc ctttatcttt tctccaaaat gctctattct tatcaataca
     1261 ctctttggaa aattcaaata atacattcca taaatcttca tcactgttta caagtgatat
     1321 ttttttatta tatttatttc ttaaataaga tataagtttt aaatcctcta aatctctaag
     1381 cactgttcta gacaatacaa atatcatttc ctgaatagta tctctaacat cattatatct
     1441 taatttgttt gtatctatta gattataaac accttctaaa ttcatatttt taatttcttt
     1501 ttcaatataa agttctaatt caaagggata ttcttttgaa gaattattga acatatctat
     1561 cggattaata atatactctt cttctaataa tctactattt gcttttttaa gtgcctcttc
     1621 aagtcttata ttttcttttc tactcttcaa tatctcctca tcttttatac taagttgatt
     1681 ttcaaaaaaa ttcctcttag ctatttcctg aataaattca gacatcatta ataaattttc
     1741 ttttaataca tataacctac ttttaggatt taatggaaat tcattgtaaa ttttgtttat
     1801 gtattttata tcaataccag aactacttga taattcagat aaatttttat ctatatcaat
     1861 agacttatat actataaaat taccacattc tatatatcca actatatttt cttctaatac
     1921 tataggtatc tctaaactgg aaacaccata ctcacaatgg tacacttttt caaagttatc
     1981 attatttatg cttttaacaa gttttttagt acactgtttt atatttttac aaatatcgca
     2041 aaatttattt tctttcttag tctcaaatat ttctttatac tttaagtcat atacagatat
     2101 tctaagcttc aatatattag atatttgatt tgcaagattt tcaattatgt ttacattaac
     2161 taactcctgt atattgtttt cagaaaatac tataggtatt tgtctcaaac tcgaaaattt
     2221 atgaggaaca taagtaatta atattactaa atcaatttta ccagtgttta taatttcatg
     2281 ttctgaatat ggtgggcaat aaactataga tgtttccttt atattgacct ttttaccatc
     2341 aattatttgt attccttctc cctgaatcac atataaaagc tgttcttcac ttaaatgaaa
     2401 atgcttttct tggcagtttc ccggaaaaaa tcttacaatt ccagcactaa gtctattgaa
     2461 ttgtgttttt gatggttcgt gtatccacat aacctctccc caatcaaatt tttgtacttc
     2521 attatttgac tcactaaaat ccaccataaa ctcacctcgt agtttttgtc taaatatttt
     2581 ttcttccctt cttatattaa aataatatca tcatcattaa ctttcattac tataaaatca
     2641 tcatactctt ttaatactcc tgtaatttta gttgcactta gtttactaca attcagtttt
     2701 ttaatatatt gataaattct ataattactt ttttattttg taaaatcagt gttttcccaa
     2761 aataattata tctataaatg aaagtatttt tactgcttac atcaatatat gttatcataa
     2821 ttttcctttt tattgcatat ataaataact gtatataaca ttgtccaata ctatatagaa
     2881 atacatctaa gaaagaatat tattaaattg ttccaattag tattattttt cttataaaaa
     2941 taaaaaaact gttggattct tttagaaaaa ttatttttta catacctttt ttgcttagat
     3001 agtctatctt ctcagctatt ttgtatatac actcttctag ttcatgattt tattttaata
     3061 tcttgcttat attgctgaaa taattgaatt cttttatcta tcatattgtc tcttatatca
     3121 taaacatatt gtttcttata tcacaaaaat gaaagcattc ttatatcttc aatatataaa
     3181 cctgcttttt ttaatcttgt aataaatata ggatactcta tattctcttc ctagaaataa
     3241 ctaatacca
//
LOCUS       DAEQCW010000205         3224 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.206, whole genome shotgun sequence.
ACCESSION   DAEQCW010000205 DAEQCW010000000
VERSION     DAEQCW010000205.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.206"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            142..1647
                     /locus_tag="KRO40_003544"
     CDS             142..1647
                     /locus_tag="KRO40_003544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HBH2094336.1"
                     /translation="MKVGFDHKKYLEEQSKYILERVNNFDKLYLEFGGKLMGDLHAKR
                     VLPGFDENAKIKVLQHMKEKVEVVICVYAGDIERNKIRGDFGITYDMEVLRLIDDLRG
                     YELDVNSVVITRFEGQPATTVFINKLERRGIKVYKHYPTKGYPSDVETIVSDEGYGAN
                     EYIETTKPIVVVTAPGPNSGKLGTCLSQLYHENKRGNVVGYSKFETFPVWNVPVKHPL
                     NIAYEAATVDLKDVNMIDSFHLETYGEMSVNYNRDLELFPVLKKIIEKITGKESIFQS
                     PTDMGVNRVGFGIIDDEVIRKASIEEIIRRYFKTACEYKKGQVDKGAYDRMKMIMEEL
                     NLKPEDRNVVLPARNYSNKLKESADKNDTCPVVALELEDGTILTGKGSDLMNGTAAVV
                     LNAIKHLANISDDMHLISPVILEPIINLKTKTLASRNVSLSCQEVLTALSICAVTNPT
                     AQFAMEKLALLKGCQAHSTTILNRDDEQTFRKLGIDVTCDPEYPSQNLYYS"
     gene            2037..3134
                     /gene="dinB"
                     /locus_tag="KRO40_003545"
     CDS             2037..3134
                     /gene="dinB"
                     /locus_tag="KRO40_003545"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HBH2094337.1"
                     /translation="MKHYRKIIHIDMDAFYASIEQRDNKKLKGRPVIVGGNPQSRGVV
                     ATCSYEARKFGIHSAMPSAVAYNRCPYAVFVRPRFDVYKSVSEQIRDIFYRYTDLVEP
                     LSLDEAYLDVTKNKKNIDSSIEIAKQIKKDIFREVGLTSSAGVSYNKFLAKIASDLRK
                     PNGLTVITEENAQDFLDKLPVNKFFGVGKVTSNTLKNLGIKTGYDLRCLNLFELENIF
                     KKRGYELYKFARGIDDRPVEPNRVRKSVGAETTLSHNLDIDEEETRNILDELCEEVCH
                     RLKNSEKFGKTLTLKIKYEDFTKITRSLSLEHYIDEYNDIRSGVDNLLRNVEVNGKQI
                     RLLGVTISNLSDKKETYKDITLFEYMDSIQM"
BASE COUNT         1284 a          336 c          573 g         1031 t
ORIGIN      
        1 atcttgaaaa aaattaatct taattgtata atattacttt gagtgaaaaa gtattaacat
       61 ttttttataa gatgttttac taaaaaaata tatataaata tactgttatc aataagaaat
      121 ttaatttagt gaggtgttaa gatgaaagta ggatttgacc acaaaaaata tttagaagag
      181 cagtctaaat atatcttaga aagagtaaat aattttgaca aactttattt agagtttgga
      241 ggaaaattga tgggagacct tcatgcaaaa agagtacttc caggatttga tgaaaatgca
      301 aagataaaag tattacaaca tatgaaagaa aaagttgaag ttgtaatttg tgtctatgca
      361 ggagatatag aaagaaacaa aataagagga gactttggta tcacttatga tatggaagtt
      421 ttaagattaa tagatgattt aagaggttat gaactagatg taaatagtgt agtaattact
      481 agatttgaag gacaacctgc tacaactgta tttataaata aattagaacg tagaggaatt
      541 aaagtttata agcattatcc aacaaaggga tatccgtcag atgttgagac tatagttagt
      601 gatgagggat atggagcaaa tgaatatata gaaactacaa agccaatagt agtagtcaca
      661 gcaccaggac ctaatagtgg aaaacttggt acttgtctaa gtcagttgta tcatgaaaat
      721 aaaagaggta atgtagttgg atattctaag tttgagacat tcccagtttg gaatgtacct
      781 gtaaaacatc ctttgaatat agcttatgaa gcagctacag ttgatttaaa agatgtgaat
      841 atgatagatt cattccacct tgaaacgtat ggtgaaatgt cagtaaacta caatagagat
      901 ttggaattat ttccagtgct taaaaaaata atagaaaaga taactggaaa agaatcaatt
      961 ttccaatctc caactgatat gggtgttaat agagttggct ttggaataat agatgatgaa
     1021 gtaataagaa aagcttctat agaagaaata ataagaagat actttaaaac tgcctgtgag
     1081 tataaaaagg gacaagttga taaaggtgct tatgatagaa tgaaaatgat tatggaagag
     1141 cttaacttaa agccagaaga tagaaatgtt gtattacctg ctagaaacta cagtaataaa
     1201 ttgaaagaaa gtgccgacaa gaatgatact tgtcctgtag ttgcattaga attagaagat
     1261 ggtacaatat taactggtaa gggttctgat ttaatgaatg gaaccgcagc agtagtatta
     1321 aatgccatta aacatttagc caatatatct gatgatatgc acttaatatc acctgtaata
     1381 ttagaaccta tcataaactt aaaaacaaag actttagcta gtagaaatgt ttcacttagt
     1441 tgccaagagg tgttaactgc acttagtatt tgtgctgtaa ctaatccaac tgcacaattt
     1501 gctatggaaa agttagcatt attaaaaggg tgtcaagctc attctactac tatattaaat
     1561 agagatgatg aacaaacatt tagaaaactt ggtatagatg taacttgtga cccagaatat
     1621 ccttcacaaa atctttacta tagttaaaat tatataaaaa aatatgggct gttttaaagt
     1681 aatagtttga gcagtccatt acaattataa taaaatcagt aggctgtctt gtataagaca
     1741 gtcttttgtt tttaaaacat cccataaatt aaatatatat actgttatcc ataaggaatt
     1801 ttaaatttag ttccttggaa tacctattgt aaagctttta tatagttttt gcaagtgttt
     1861 ttaaggattt tttataaatt atattgaagt taatggatta tagatggttt tatttatgga
     1921 aaatatgaat atataaagaa aataatgaaa aaataccaaa aagaaacata agtttggtat
     1981 aattaaaaag taatataaat aaaattaatc tatttatact ttaaaaggtg ataataatga
     2041 aacattatag aaaaataatt catatagata tggacgcttt ttatgcatct atagaacaaa
     2101 gagataataa aaaattaaaa ggaagacctg ttattgtcgg tggaaatcca caaagccgag
     2161 gtgtggttgc aacgtgttct tatgaagcta gaaaatttgg tatccattca gctatgccat
     2221 cagctgtagc ttacaatagg tgtccatatg cagtttttgt aagacctaga tttgatgttt
     2281 ataagagtgt gtcagagcaa ataagagata tattttatag atacacagat ttagttgaac
     2341 cattatcttt agatgaagct tacttagatg taacaaaaaa taaaaaaaat attgattcat
     2401 caattgagat agcaaagcaa ataaaaaaag atatatttag agaagttggt cttacttctt
     2461 cagctggtgt gtcatacaat aagtttcttg ctaagattgc atcagactta agaaagccaa
     2521 atggattaac tgtaataacc gaagaaaatg cccaggactt tttagataaa ttacctgtga
     2581 ataaattttt tggtgttgga aaagttactt caaatactct taaaaattta ggtataaaaa
     2641 ctggatatga tttaaggtgt ttaaatttat ttgaacttga aaatatattc aaaaaaagag
     2701 gttatgaatt atataaattt gctagaggaa tagacgatag accagtggaa ccaaataggg
     2761 ttagaaaatc tgttggggct gagactacat taagtcataa tttggatatt gatgaagaag
     2821 aaacacgcaa cattcttgat gaactttgtg aagaagtatg tcatagatta aaaaactctg
     2881 agaagtttgg aaaaacatta acattaaaaa ttaaatatga ggactttaca aagataacta
     2941 gaagccttag tttagaacac tatattgacg aatataatga tataagaagt ggtgtagata
     3001 atttgttgag aaatgttgag gttaatggaa aacaaattag gctattggga gttacaatat
     3061 caaacctaag tgataaaaaa gaaacttata aagatattac attatttgaa tacatggata
     3121 gtatccaaat gtgagttttg tttaaatgaa ataacactag ctttaatact atataattga
     3181 ggctagtgtt attttatgaa tatttttata ttttatattt tttg
//
LOCUS       DAEQCW010000206         3115 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.207, whole genome shotgun sequence.
ACCESSION   DAEQCW010000206 DAEQCW010000000
VERSION     DAEQCW010000206.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3115)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.207"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            458..1381
                     /locus_tag="KRO40_003546"
     CDS             458..1381
                     /locus_tag="KRO40_003546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2520 domain-containing protein"
                     /protein_id="HBH2094338.1"
                     /translation="MGSGKVGTSLANYFLSKGYCVSGFYGRNQLSLLESTNLTKTKIY
                     SNLKDIIYENDILFITTSDDSIEIIDKKLSKFNLKHKYICHTSGSLKSSILFCSKKAG
                     ALIYSIHPIFAFSNKNTNIKKMKDICFSIEGDNEQDDLVIQNFIDDLGNQFFIRDKDT
                     SSTYHLANVLVSNLVLSLLDIGVSYFIKLGLSEEESLKAISPLVKKNIENILDNGFTK
                     ALTGPVSRGDITPIRKHLSVLDKKDEDIYKILSLNLLKIIALGNDNSLKGIKNITIEN
                     AIENLISKSEKYKEIYKLLGGKNDEKYHTDF"
     gene            1356..2183
                     /gene="panB"
                     /locus_tag="KRO40_003547"
     CDS             1356..2183
                     /gene="panB"
                     /locus_tag="KRO40_003547"
                     /EC_number="2.1.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate
                     hydroxymethyltransferase"
                     /protein_id="HBH2094339.1"
                     /translation="MKNTIQTFKNAKYEGKKLSMLTAYDYSIAKIMDECDINGILIGD
                     SLGMVIKGEENTLSVTIDEIIYHTKAVKNGVKNALIVSDMPFLSYHVSIEDAVKNAGR
                     LIKEGGAHAVKLEGGSNVIKQIESIVNAQIPVMGHLGLTPQSVNSFGGFKVQGNTSET
                     ARQLIEDAKLIEKAGAFSIVLEGVPTKIAEMVTNSISIPTIGIGAGINCDGQILVYQD
                     MLGMFGDFVPKFVKQYANIGDIMKDSIKNYILEVNTGAFPQEKHSFSINESELEKLY"
     gene            2202..3050
                     /locus_tag="KRO40_003548"
     CDS             2202..3050
                     /locus_tag="KRO40_003548"
                     /EC_number="6.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantoate--beta-alanine ligase"
                     /protein_id="HBH2094340.1"
                     /translation="MLVKEIKLLRNIIKDWRKHGYSIGLVTTMGFLHEGHQSLIKKAI
                     KENDKVVVSVFVNPTQFGPNEDFNSYPRDIDKDFKYCMDSGATVVFNPSPEEMYLKGN
                     CTTINVSGLTDFLCGAKRPVHFGGVCLVVSKFLNIVTPDKAYFGEKDAQQLAVIKRMV
                     KDLNIDTEIIGCPIIRENDGLAKSSRNTYLSEEERKSALILNKSLSLAKEELVKGNLN
                     PENIKELIIAKINSEHLAKIDYVEIVDSETLQPVKQIEHSILVAIAVFIGKTRLIDNF
                     TFELNI"
BASE COUNT         1253 a          364 c          474 g         1024 t
ORIGIN      
        1 attacataat acatctctct cttatattaa attttaactt ggtactaatc ttgacaaatt
       61 gtccacaaaa ataaattata gattttatta ttgttttaaa tttttataaa aaaatcagta
      121 ttattgatac tattgaagtt aaaaagcatt aatttctaaa aacatcataa tttttctaat
      181 agacttaatc acttttaata tatatagtaa aacaaaaaac ttatatttta taaatatcat
      241 aattttttta ctgatatttt attatataaa ttttatagaa ttaattgtca attttttatg
      301 aaaatggtaa gatatttatg gatggtatct tgttataaga actatacttt aaatgttttt
      361 aattattttg tcttatgtaa ctcatatcct caggaatgag attagaaatt aagatgttgt
      421 atcacaaagt ggaggtgata ctattaaaat aggctttatt ggttctggaa aagttggaac
      481 atctttggca aattattttt tatcaaaagg ttattgtgtt tcaggctttt atggaaggaa
      541 tcaattatct ttattagaat caacaaattt aacaaaaaca aagatttaca gcaatttgaa
      601 agatataatt tatgaaaacg atatattatt tattacaaca tcagatgatt ctattgaaat
      661 tatagacaaa aaactttcca aatttaattt aaaacataaa tacatttgcc acacaagtgg
      721 ctctttaaaa tctagtatat tgttctgttc aaaaaaagca ggtgcattaa tttattctat
      781 ccatcctata tttgcatttt ccaataaaaa taccaacata aaaaaaatga aagacatttg
      841 tttttccata gaaggtgata atgaacaaga tgatttagtt attcaaaatt ttatagatga
      901 tttgggaaac caatttttta taagagataa ggatacttca tccacttatc atttagctaa
      961 tgttttagtt tcaaatttag tattatcttt actagatata ggagtaagtt actttattaa
     1021 attaggttta tctgaagagg aatctttaaa agctatcagt cctttagtaa aaaaaaatat
     1081 agaaaatata cttgataatg gctttactaa agctcttact ggtcctgttt ctcgtggaga
     1141 tataacacca ataagaaaac atctatctgt attggataaa aaagatgagg atatttacaa
     1201 aatactatcc ttaaacctac taaaaataat tgccttagga aatgacaatt cattaaaagg
     1261 tataaaaaat attactatag aaaatgcaat cgaaaattta ataagtaaat ctgaaaaata
     1321 caaagaaatt tacaaacttt taggaggaaa aaacgatgaa aaataccata cagactttta
     1381 agaatgctaa atatgaagga aaaaaactat ctatgcttac tgcttatgac tactcaattg
     1441 caaaaataat ggatgagtgt gatataaatg gtattttaat aggagattca ttaggaatgg
     1501 tcataaaagg tgaagaaaac actctatctg ttaccataga cgaaattata tatcatacaa
     1561 aagctgtaaa aaatggtgta aaaaatgcct taatcgtaag tgatatgcct tttctatctt
     1621 accatgtttc tatagaagat gcagttaaaa acgctggtag acttataaaa gaaggaggag
     1681 ctcatgctgt aaagttagaa ggtggctcaa acgttataaa gcaaatagaa agcattgtaa
     1741 atgctcaaat acctgtaatg gggcatttag gattaactcc tcaatcagta aattcatttg
     1801 gtgggtttaa ggttcaagga aataccagtg aaacagcaag acaacttatt gaagatgcta
     1861 aattaataga aaaagcaggt gcattctcta ttgtccttga aggagtgcct acgaaaatag
     1921 ctgagatggt aactaattct atttcaattc ctacaatagg tataggggca ggaattaact
     1981 gtgatggaca aattttagtt tatcaagata tgttgggaat gtttggagat tttgttccta
     2041 agtttgtaaa gcagtatgca aatataggag atataatgaa agattcaatt aaaaattaca
     2101 tcctagaagt taatacaggt gcatttccac aagaaaaaca cagcttttca ataaatgaat
     2161 ctgagttaga aaaattatac taatattaag gatggtacaa aatgcttgta aaagaaatta
     2221 aattactaag aaatataatc aaagattgga gaaaacatgg ctattctata ggccttgtta
     2281 caacaatggg atttttacat gaaggacacc aaagtcttat aaaaaaagct ataaaagaaa
     2341 atgataaagt agtagtgagt gtatttgtaa atccaactca atttggacca aatgaagatt
     2401 ttaatagcta tccaagagat atagataaag attttaaata ttgtatggat agtggagcaa
     2461 cagtagtctt taacccatca ccagaagaaa tgtatttaaa aggtaattgt actaccatta
     2521 atgtttctgg acttacagat tttctttgtg gagctaaaag acctgttcat tttggaggtg
     2581 tctgcctagt tgtttcaaag tttctaaata tagtaacacc tgataaagct tatttcggag
     2641 agaaggatgc ccaacaatta gctgtaatta aaagaatggt caaggattta aacatagata
     2701 cagaaataat aggctgtcct ataattcgtg aaaatgatgg attagcaaaa agttcgagaa
     2761 atacatatct ctctgaggaa gaacgaaaat ctgctctaat attaaataag agcttaagtt
     2821 tagcaaaaga agaattagta aaaggcaatc taaatccaga gaatataaaa gaattaataa
     2881 tagctaaaat aaattctgaa cacttagcaa aaatagacta tgttgaaatt gtagatagtg
     2941 agacattaca acctgttaag caaatagaac attctatact tgtggcaatt gctgtgttta
     3001 taggaaaaac cagactaatt gataatttta catttgagtt aaatatatag tctataattt
     3061 tatataatat atctaaaaaa taatagaata cctaaaaagt aataaattac ctaaa
//
LOCUS       DAEQCW010000207         3022 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.208, whole genome shotgun sequence.
ACCESSION   DAEQCW010000207 DAEQCW010000000
VERSION     DAEQCW010000207.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3022)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3022)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3022
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.208"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            162..1055
                     /locus_tag="KRO40_003549"
     CDS             162..1055
                     /locus_tag="KRO40_003549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBH2094341.1"
                     /translation="MKNKKFIVIILIISILIGVLVKEYSSREIKKDDINVSKYIKYAD
                     LASKNNAQVNWKYVASIVAVLNKNNLKNVKDSQIQEVSDLFVKNFSKNNKINKLSDIL
                     DELEFSNRQKRLVDNYIDNLKDYGIKPERLKSDTKYMKFIDEIKTEAIQNYKDYKILP
                     SITIAQAIIESSWGKSTLAKQYSNLFGIKADAYWKGKSVTLETKEHLDTIIDDKFRIY
                     DDKNESIKDHAKFLATNKRYKNNGVFDAKTYIYQAKALEKAGYSTAKDENGNSIYAAR
                     LIELIQQYNLQLIDSEIQSEM"
     gene            1492..1983
                     /locus_tag="KRO40_003550"
     CDS             1492..1983
                     /locus_tag="KRO40_003550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094342.1"
                     /translation="MYENNKVIYNLERCEKLEKTLYLSQFNTYKNFKLASKKTVINSL
                     ETYVYNMNINNISLVDTIECISLEYEQLTGKKLILVGDIDIDAILDYAGNKRNRNSSK
                     KNTFKLKIPFSTFIQMPRKIENKDKINLKYLIQDITSSILDDNLFISVTAIISYENSS
                     KIE"
     gene            2011..2958
                     /locus_tag="KRO40_003551"
     CDS             2011..2958
                     /locus_tag="KRO40_003551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094343.1"
                     /translation="MRITKTTFNDVFSNDANGSIIKVEKYVDKKCASVFEILTYTIIV
                     TNTSRYKTGNIFFKDYISKYIEFINNTVKVNGIIKRGLDPQQGFYIGRIDASCKKIIS
                     FKSVVLPNSAHRIIKNSANIYYYYKCNLDKFPTRISIESNRVYTNVNKIVFKQLNISN
                     TLKAPKNLRDILKVNVNSKIFDVKPMKNLINKGSNLKLCNLIVFGCIEVEIDYSCKNR
                     SNFKTVNKSNDIKKDKYYKNDIQNNNENINDCKKQISFGDNKVKKITKTFGFSCFICS
                     PVGIIYEDMKNINIKIEHTSINELNPEELFVNTSLLLYY"
BASE COUNT         1322 a          265 c          426 g         1009 t
ORIGIN      
        1 actattttgt gtgatagaaa actatatatt ataacaatag tagtgctttt aattaaatat
       61 atttcataaa tcttcataaa atcttcaaaa tttcgtaaag aatatgtcac aaaagtaagg
      121 tatattatat tcagcagata gtataaggga ggacaatatt tatgaagaat aaaaaattca
      181 ttgttataat actgataata tcaattttaa taggtgtatt agtgaaggaa tattcatcta
      241 gagagataaa aaaggatgat ataaatgtca gtaagtatat aaaatatgct gatttagcaa
      301 gtaaaaataa tgcacaagtt aactggaagt atgtagcttc cattgttgct gtgttaaata
      361 aaaataactt aaaaaacgtt aaggattcac agatacaaga agtatcagat ttatttgtta
      421 agaatttttc taaaaataat aaaataaata agttaagtga tattttggat gagttagaat
      481 ttagtaatag acaaaaaaga ttggttgata attatataga caatcttaag gattatggta
      541 taaaaccaga aagattgaag tctgatacaa aatatatgaa gtttattgat gaaattaaaa
      601 cagaagcaat acaaaattat aaggattata aaatacttcc atctataact attgcacaag
      661 ctataataga atctagctgg ggcaagtcaa ctttggcaaa acaatatagc aatctatttg
      721 gtataaaggc tgacgcttat tggaaaggta agtcagtgac tttagaaacg aaagaacatt
      781 tagatacaat tatagatgat aaatttagaa tatatgatga taaaaatgaa tctataaaag
      841 accatgcaaa atttttagcc acaaataaaa ggtataaaaa caatggtgta tttgatgcaa
      901 aaacgtatat atatcaagct aaagcattag aaaaggcagg ttatagtact gcgaaggatg
      961 aaaatggcaa tagtatatat gcagctcgtc taatagaatt aattcaacag tataatcttc
     1021 aattaataga cagtgaaatt caaagtgaaa tgtaactttg attaaatttt tattgataag
     1081 gctatgattt ttaaaatcat agccttattt tgacatgctt ttacttgtaa ttattaaatc
     1141 gatatcatta tctttcaaaa tttactttat actgtaaatc aaattattta agttaaaact
     1201 tggaattatt tataaaagga ttatttactt tatctaaatt ctgcacttaa agaacatctt
     1261 ttcccttaag actgaccgtt agtctataaa aattataatt acttataaaa aagtgaatat
     1321 atatataaag ttttcagaaa gacttttact tgtaaattga aatcaatgaa gtaaaaaagg
     1381 attctttctt aaaagtaaat aacaactaga tagtgaataa taaaaaatgg taatttgaaa
     1441 taatttttat gaatagtatt aatatataga tacagggaga ttgatgcgat tatgtatgaa
     1501 aataataagg taatatacaa ccttgaaaga tgtgaaaaac tagaaaagac tctttattta
     1561 tctcaattta atacatataa aaattttaaa ttagcttcta aaaaaactgt aataaattca
     1621 ttagagacat atgtttacaa tatgaatatt aacaatataa gtcttgttga tactatagaa
     1681 tgtatatcat tagaatatga acaacttaca ggaaagaagt tgattttagt tggtgatata
     1741 gatattgatg caatattaga ttatgcagga aataaaagaa atagaaattc tagtaaaaaa
     1801 aatacattta aattaaaaat accctttagt acatttatac aaatgcctag aaagatagaa
     1861 aataaagata aaattaattt aaagtatctt atacaagata ttacttcatc tattttagat
     1921 gataatttat ttattagtgt tactgcaatt ataagttatg aaaatagttc caagatagag
     1981 taatctttaa attatagaaa ggtggatgca atgagaataa cgaaaactac ttttaatgat
     2041 gtattttcaa atgatgcaaa tggaagtatt ataaaagtag aaaaatatgt tgataaaaaa
     2101 tgtgcatctg tatttgagat tttgacctac actattattg ttacaaatac aagtaggtac
     2161 aaaactggaa atatattttt caaagattat atttctaaat atatagagtt tataaataat
     2221 actgtaaaag ttaatggcat tataaaacgt ggattagacc cacaacaagg tttttacata
     2281 gggagaatag atgcaagttg taaaaaaata atatctttta agagtgtagt tttaccaaat
     2341 tctgcacata ggattataaa gaatagtgct aatatatact attattataa gtgtaatcta
     2401 gataaattcc caacaagaat atcaatagaa agtaatagag tttatactaa tgtaaataaa
     2461 attgtattca aacaattgaa tataagtaat actttaaaag ctcctaaaaa tctaagagat
     2521 atattaaaag taaatgtaaa tagtaaaata tttgatgtta aacctatgaa aaatcttata
     2581 aacaaaggta gtaatttgaa attatgtaac ttgatagttt ttgggtgtat agaagttgaa
     2641 atagactata gttgtaaaaa taggagtaat tttaaaacag taaataagtc taatgacatt
     2701 aaaaaagata agtattataa aaatgatata caaaataaca atgaaaatat aaacgattgt
     2761 aaaaagcaaa taagttttgg tgataataag gtaaaaaaaa taacaaaaac ttttggattt
     2821 tcttgtttca tttgttctcc agttggaatt atttatgaag atatgaaaaa tataaatata
     2881 aaaattgaac atacatcaat aaatgaatta aatccagaag aattatttgt aaatacatca
     2941 cttttattgt attattaagt attttaaagc taaaacttaa acttattaaa atagcatttg
     3001 gttaaaggaa aatagatatt ga
//
LOCUS       DAEQCW010000208         2894 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.209, whole genome shotgun sequence.
ACCESSION   DAEQCW010000208 DAEQCW010000000
VERSION     DAEQCW010000208.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2894)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.209"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            183..383
                     /locus_tag="KRO40_003552"
     CDS             183..383
                     /locus_tag="KRO40_003552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBH2094344.1"
                     /translation="MNNGIVKWFNNEKGFGFISMEGRDDVFAHFSAIQTSGFKSLEEG
                     QQVSFDIVKGARGPQAENITIL"
     repeat_region   748..915
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=748..775
                     /rpt_unit_seq="tttacataccacatagttgatataaaac"
     gene            1386..2231
                     /locus_tag="KRO40_003553"
     CDS             1386..2231
                     /locus_tag="KRO40_003553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094345.1"
                     /translation="MNIIKSITLLLTLLIVILMTGCSPRESASEVAKKYIDKMNSGDY
                     ETAYSLLSKDSKKKISIENLEEFQNILVSTKRIISYKIGKEKIIKKYKHDGKEYKNVV
                     KLEETFNIKNLLYKKDDSLKVNRYFVVENNKYKLLLYESFKKEFGINSMDLAQLKLND
                     FGLKYFKEVDLILKKAIAINPTDSKLYYAQACNYMNFDGFPGYSDTTYNALDSINKSL
                     KYLDKNDSDYKKNASNIYNLKGVILMFHKRFDEAQQYLNKSLYFNKDNEDPKYNLNTI
                     KKHLN"
     gene            complement(2455..2619)
                     /locus_tag="KRO40_003554"
     CDS             complement(2455..2619)
                     /locus_tag="KRO40_003554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094346.1"
                     /translation="MFGKPKESVRFLDFNDVAEKFGEKKAVAIFDAIAGKKSKEHIIK
                     DIEKLVKNEV"
BASE COUNT         1157 a          353 c          332 g         1052 t
ORIGIN      
        1 tttatattaa tatatagcaa tgtaaaacgt ttaaatatat ttttaatatt aagaataact
       61 aaaatgttaa ctaaaaaata taattaagta gacatttcta ttaatctatg atacaatagt
      121 atttgtggta atacacaatt aaatcaagta tatcttgata taggttaata ggagtatttt
      181 taatgaataa tggaatagtg aaatggttta ataatgaaaa aggattcggt tttatatcaa
      241 tggaaggtag agatgatgtg tttgctcatt tctcagctat acaaacttca ggatttaaat
      301 cattagaaga aggtcaacaa gtaagctttg atatagttaa aggtgctaga ggtcctcaag
      361 cagaaaatat aactatatta taatatatag atttttcggg aaagactctt tttagagtct
      421 ttttttattg ttaatatatg taagataatc attggtgaag taaataaggt atattgagta
      481 atgttcttga tagtttatat gctaatgaat ttcaaaaaaa taagcactcc tataaaaaga
      541 gtgctcttaa tgtaaatata aaccttcatt ggtccagcct aataccccgt attctccaag
      601 ttctaactct tttttatata cattatcact ttcagccata tctaacacaa tcatttcttc
      661 tttagaatca atttgtaaaa tatgaggact gtgtgttgtg acaattattt gtgtttttgg
      721 gagaattgtt tttaatgtaa taaaaatttt acataccaca tagttgatat aaaacgtaaa
      781 tacaccatct ataaagggca ggtgttaaaa ctctttacat accacatagt tgatataaaa
      841 cttaatatac ttaggtattc ctactggaaa cttttctctt tacataccac atagttgata
      901 taaaacccca aaataaactt agcatctcca atgtttacac atatacaatg ctcttaaaat
      961 tgcagtgaac gcgcaatagt gcaattgata atacttatta tatattctca atgccttata
     1021 tttcaactgc taaacctcaa tttgtcacaa atatcgctca ctgcaaaatt tctatatttt
     1081 tattatatca taacatataa ttaatatttt caattaattt ttacatttaa ttatgtttaa
     1141 attctataat aatgcaactt taatgtttct ttctggaact aatataaaaa ctatttcaga
     1201 aagattaggt catgcagata taaaaataac tatgaatagc tactctcagt ttttagaaga
     1261 gatggacaga gaagcatttg aaaatttgag caaaatacta tttattatat tttaaagaag
     1321 atgacttatt caatatttga tgctagaata taattaataa aaatttaatt ataggtgatt
     1381 gtattatgaa tattattaaa agcataactt tactcttaac attattaatt gtgatattaa
     1441 tgacaggctg ttccccaaga gaaagtgcta gtgaagttgc aaaaaaatat attgataaga
     1501 tgaactctgg tgactatgaa acagcatata gtttattaag taaagatagt aaaaaaaaaa
     1561 ttagtataga aaatcttgaa gaatttcaaa atattttagt tagtacaaaa agaataatta
     1621 gttataaaat aggtaaagaa aaaatcataa aaaaatataa acatgatgga aaagaatata
     1681 aaaatgttgt taaattagaa gaaactttta atataaaaaa ccttctttat aaaaaagatg
     1741 attctctaaa agtaaataga tattttgtag ttgaaaataa caaatacaag ctattattgt
     1801 atgaaagttt caaaaaagaa tttggtatta atagtatgga ccttgctcaa cttaagctta
     1861 atgattttgg actaaaatac tttaaagaag ttgaccttat actaaaaaaa gctattgcta
     1921 ttaatcctac tgattcaaag ctttattatg cccaagcatg taattatatg aattttgatg
     1981 gatttcctgg ttattcagat acaacatata atgctttaga ttcaattaat aaatctttaa
     2041 agtatttaga taaaaatgat tctgactaca aaaaaaatgc aagtaatata tataacttaa
     2101 aaggagttat tcttatgttt cacaaaagat ttgatgaagc acaacaatat ttaaataagt
     2161 ccttatactt taacaaagat aatgaagacc caaaatataa tctaaataca ataaaaaaac
     2221 atctaaacta gatatttaat ttttgaattt ataaaatatt tttttatgta taattcagca
     2281 ctgaatcata atctctacta aactaattac aagtttaaat tataaagact tatttctata
     2341 taaatattac tctataacaa taagtttctt atttaaattt taaaatatta tctaaaaatc
     2401 ataaaaaaga aggtataaag agctaccctc aagctcaata taccttataa atatctaaac
     2461 ttcatttttt actaattttt ctatatcttt gataatatgt tctttagatt tttttccagc
     2521 tatggcatca aaaattgcaa cagccttttt ctctccaaac ttttctgcta catcattaaa
     2581 gtctaaaaat ctaacacttt cttttggttt accaaacata taacacctct catacatttt
     2641 tatatattta ttataacttc tatagactta tttttcacca ataaacgtta gacaaattag
     2701 tccctttatt tttttaaact agttttacct tcaaaattct taacaaaaac agtttattct
     2761 actctataaa taaaaataga caatttaatt tgtaggaaac tgataataga atacagtaaa
     2821 taaaactttg tttaatctat ctgaaaaagt tatctattaa aactgctatg aatttataaa
     2881 gaatattcta gttc
//
LOCUS       DAEQCW010000209         2871 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.210, whole genome shotgun sequence.
ACCESSION   DAEQCW010000209 DAEQCW010000000
VERSION     DAEQCW010000209.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2871)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.210"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            12..386
                     /locus_tag="KRO40_003555"
     CDS             12..386
                     /locus_tag="KRO40_003555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2094347.1"
                     /translation="MNIVISNSSGKPIYEQITTQIKSMIISGELPEGSALPSMRLLAK
                     ELRISVITTKRAYSDLERDGFIETVTGKGSFVSSKNMDFVKEEQFRLIEEYLQKAVDT
                     AKSSDITYDELKDILFLLYKGE"
     gene            383..1246
                     /locus_tag="KRO40_003556"
     CDS             383..1246
                     /locus_tag="KRO40_003556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094348.1"
                     /translation="MISMDAITIKNLNKTYKDFSLQDISFSVPKGSVMGFVGENGAGK
                     TTTLKAILNLISYDSGNIEIFGLDSKKNEKEIKEQIGVVFEGSNFHENLNTDHVSKIM
                     SKIYKNWNDTLFKDYLKKLRVPDNKLIKEFSKGNKMKLSIAVALSHKPKLLILDEATS
                     SLDPIVREEILDIFLDFIQDEEHSIILSSHITSDLDKIADYITFIHKGKIVFSENKDE
                     LIDTMGVLKCKPSDFDNLSREDYSYYRKSQFGYEVLLKDKHRFISRHPNCIVDNTSIE
                     EIMLFYVRGDK"
     gene            1246..1884
                     /locus_tag="KRO40_003557"
     CDS             1246..1884
                     /locus_tag="KRO40_003557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBH2094349.1"
                     /translation="MKGLILKDLLNLKGNIKFILLFIIMFGFMSSLGDGNVNNFIGVI
                     IVLCTTMIVSTFSYDDLNKWDSYVLTMPINRNDIVLSKYLTMLIFSFIGVLVSLIVSV
                     TIGYFKNTLILNETLLINALILSISVCFGSLILPLIYKFGTERARLLMILCFLVPTLA
                     LLVFKSILENISSPISIEIILNTLVYSLPFVAILLFVISYFISSKIYSKKEV"
     gene            2376..2789
                     /locus_tag="KRO40_003558"
     CDS             2376..2789
                     /locus_tag="KRO40_003558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2094350.1"
                     /translation="MELEITEKIEKQDEDTIFQGLLKYNLARLEDKNPVDLGIYIRDK
                     AGKIVAGFIGVTHGNWLSIKYLWVSEKLRYKGTGSQLLYKAEKIAKERGCKYVFLDTF
                     SFQAPKFYEKFGYHKVFSLENYPLTGKRYYYRKIL"
BASE COUNT         1107 a          294 c          407 g         1063 t
ORIGIN      
        1 gaggtgtctt attgaatata gttattagta attcgagtgg gaagccaata tatgaacaga
       61 ttactacaca aattaaaagt atgattataa gtggagagtt accagaaggc tcagctcttc
      121 caagtatgag actattggca aaagaactta gaataagtgt aattactaca aaacgagcat
      181 atagcgattt agaacgagac ggatttattg agacagttac tggtaaaggc agttttgtat
      241 ctagtaaaaa catggatttt gtcaaagaag aacaatttcg tttaattgaa gaatacctac
      301 aaaaagcagt tgatacagca aaaagtagtg atattacata tgacgaatta aaagatattt
      361 tatttttatt atataaagga gaatgataag tatggatgca ataactataa aaaatttaaa
      421 taaaacttat aaagatttta gcctacaaga tatatctttt tcagtaccaa aagggagtgt
      481 aatgggattt gtaggtgaaa atggtgcagg aaaaacaact acattaaaag caattttaaa
      541 tttaatatct tatgatagtg gaaatataga aatctttggt cttgatagta aaaaaaatga
      601 aaaagaaatt aaagagcaaa ttggggttgt atttgaggga agcaactttc atgaaaattt
      661 aaacactgac catgtttcaa aaatcatgag taaaatctat aaaaattgga atgacacatt
      721 atttaaagac tacttaaaaa aattgagagt accagacaat aaattaatta aggagttttc
      781 aaaggggaat aagatgaaac ttagtattgc tgtagcctta tctcataaac caaaattatt
      841 aatactagat gaggcaacta gttcacttga ccctatcgtt cgtgaagaaa tactagatat
      901 atttttagat tttatacaag atgaagaaca ctctattatc ttatcttcac atattacaag
      961 tgatttagat aagatagcag actatattac atttatacat aaaggaaaaa ttgtatttag
     1021 tgaaaataag gatgaattaa ttgatactat gggagtttta aaatgtaaac ctagtgattt
     1081 tgataacctt tcaagagagg attattcata ttatcgtaaa agccaatttg gatatgaagt
     1141 acttcttaaa gataagcata gatttatctc aagacatcca aactgtattg ttgataatac
     1201 gtctatagaa gaaattatgt tattttatgt gagaggtgat aaataatgaa aggtctaatt
     1261 ttaaaagatt tacttaattt gaaaggaaat ataaagttta tacttttatt catcattatg
     1321 tttggcttta tgtcttcttt aggagatgga aatgttaata actttatagg tgttattata
     1381 gttttatgta ctacaatgat tgtttcaaca ttttcatatg atgatttgaa taaatgggat
     1441 agttatgtac ttacaatgcc tattaatcgc aatgatattg tattaagtaa atatttaact
     1501 atgttaatat ttagctttat aggtgttctt gtttcactta ttgttagtgt aactattggt
     1561 tattttaaaa atacacttat attaaatgaa acactactta ttaatgcact aatcttatca
     1621 atttcagtat gttttggtag ccttattcta ccacttattt ataaatttgg tacagaaaga
     1681 gctcgtttat taatgatttt atgcttttta gttccaacac tagctttatt agtttttaaa
     1741 agtattttag aaaatattag ttcacctatt tctatagaaa ttatacttaa tacactagta
     1801 tattctcttc catttgttgc tattttacta tttgtgattt catattttat atcatcaaaa
     1861 atctatagta aaaaagaagt ataaaatata ctatatatgt ttctgtattt aagtatttaa
     1921 ataaaatact atcgagttta ttttggtagt attttatttt ttaattatta atctctacta
     1981 ggtatttatt attttattac ttatatttaa taagactatt tactactttc taatcttatt
     2041 tatataattt attcatttta taaattgaac tactaatgat attattgaac atagcaatag
     2101 aataacatct aaaatagttt ttatgtatta aattaactta ttttaatatt caacaattta
     2161 ggtttactaa atttattgat gatttctttt tatataactt aaactacatt tttatttaaa
     2221 aaaatttaat atcaacaata taaaattaag aataagtatt attagtttga cattagcata
     2281 aatgcctatt agaataatgt taaactatat tctttctact gattttatta aaaaatacca
     2341 atatacaaaa gattatacaa ggagaaagtt caaatatgga attagaaatt acagaaaaaa
     2401 tagaaaaaca agatgaagat actatttttc aaggattatt aaaatataat cttgctagac
     2461 ttgaagataa aaacccagtg gatttaggaa tatatattcg agataaagca ggtaaaattg
     2521 ttgcaggttt tataggtgtt actcatggta attggctttc tataaaatac ttatgggtta
     2581 gtgagaagct tagatataaa ggtactggaa gtcaactttt atataaggct gaaaaaattg
     2641 ctaaagaacg aggttgtaaa tatgtttttt tagatacatt cagttttcaa gcacctaaat
     2701 tttatgagaa atttggatac cataaagtat tttcacttga aaattatcct ctaactggaa
     2761 agagatatta ttatagaaaa atactataat aataaaaatc atatttcata tttttaaatt
     2821 aaaacttctg ctcttcgtct acagacttta tgtttttata tcattattaa t
//
LOCUS       DAEQCW010000210         2854 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.211, whole genome shotgun sequence.
ACCESSION   DAEQCW010000210 DAEQCW010000000
VERSION     DAEQCW010000210.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2854)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.211"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            388..2199
                     /locus_tag="KRO40_003559"
     CDS             388..2199
                     /locus_tag="KRO40_003559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBH2094351.1"
                     /translation="MKKKYDFLIYSAIWLVIIILFIFSLYHSIEHIKIISHTGTIRSE
                     TQKVVKQELNNERNDDLIKRLDNILIKLRTGNGENGFQRCDNKEFQQKLNQMDSMWES
                     MKKEIIKVRNGASGDKLYKLSEEYSVLSNQIVFISEKHSNAKLYSFATALFIYLIFST
                     ISLLIWEYYNKKRFKRIFYTDNLTKIKNQVAFENRAIEILHNASNKEYVLLNIDIDNF
                     KYINDTHGYEYGDKVLIIVAAALSKTFNIKETCARIGSDNFVILAKYRDSLLEDIREM
                     LTNAIISELDMNVTQTISYCIGAYLVEIDNLGYKSINSIMDKANIAHKVSKTRGISST
                     VWYNENLLKQLQMENSIYNYMYKAIENEEFHMYLQPKFQISSLNVVSAEALVRWFSPE
                     LGFLSPDEFIPLFEKSGFIIELDFYMLKKACSFVRKTFMKKNQYTYPIAVNFSRVTIY
                     QNSFYQRFLDTVKEYEIPFKYIEIEVTESAFNEISQPVISILEELKKLGFLISMDDFG
                     SGYSSLSLLCSLSINGLKLDKSLLKETFNREKVYSIIQCIIEMSHRIGMSVVCEGIET
                     KKDLEFLNTVKCDVGQGFYFSKPIEEKEFFNKYVTKK"
     gene            complement(2287..>2854)
                     /locus_tag="KRO40_003560"
     CDS             complement(2287..>2854)
                     /locus_tag="KRO40_003560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094352.1"
                     /translation="KINQFEKSYDIGIFKNEQSIYKFIAKIPFVKKDNSNFNYTNYYM
                     EFEDIPEYYEVNFNNYLYIITRFSFIPDGTEIFFTWEEIHCWDEKVATEKTFINGETL
                     VDSYNFPNNEVKDYIQKRESLYIETKKYYEEKGLKIERHALGSEDGEYVELTNDSILY
                     LLDIEAVEIREQSKNIEEFLYKYKKRFK"
BASE COUNT         1077 a          294 c          406 g         1077 t
ORIGIN      
        1 taaattcaaa gagttaaatt gtaggtaaat agtattttaa ttatttatta aaatatagat
       61 tatgtatatg ccaaatttaa aaagagacat aaagacatta tacaaatata ttattggggt
      121 gatattttat aagaaaagaa gtgatgcagt aaattaattg agcaatttaa aaatgattta
      181 atgatagtgt tgatgaatgt ttaaaaagaa attttagaaa aacgtatatt gctgtttgtg
      241 ttggaggtga tgaatttgta taatttatag gatataaatg attaaactat ttaagataaa
      301 tacatatcac tgtaaaatat tgataatcat tttttataag agattgatta tttgcaaatt
      361 atatatatta caaatgaggt aacaataatg aagaaaaaat atgatttttt aatttattct
      421 gctatttggc tagttattat tattcttttt atattttctc tatatcacag tatagagcat
      481 attaaaatta taagtcacac tggtactatt cgcagtgaaa ctcaaaaggt tgttaagcaa
      541 gaattgaata atgaaagaaa tgatgacttg ataaaacgac tggataatat tctgataaag
      601 ctaagaacag gtaatggaga aaatggattt caaagatgtg ataataaaga atttcaacaa
      661 aaactaaatc aaatggattc tatgtgggaa tctatgaaga aagaaattat aaaagttaga
      721 aatggtgctt caggtgataa attatataaa ttgagtgaag agtattctgt gttgtctaat
      781 caaattgttt ttatatctga aaaacactct aatgcaaaat tgtattcttt tgctactgca
      841 ctatttattt atcttatatt ctcaacaata agtcttttaa tttgggaata ttataataaa
      901 aaaaggttta aaagaatatt ttatactgat aatttaacaa aaataaaaaa tcaggttgca
      961 tttgaaaaca gagcgattga aattttgcac aatgcatcta acaaagagta tgtactgcta
     1021 aatattgata ttgacaattt taaatatatt aatgatacac atggatatga atatggagat
     1081 aaagttctaa taatagttgc agctgcactt tctaaaactt ttaatatcaa agaaacttgt
     1141 gcaagaattg gttcagataa ttttgtaata cttgcaaaat atagagattc tcttttagag
     1201 gatattcggg aaatgctaac taatgctata atctctgaat tagatatgaa tgtaactcaa
     1261 actatatctt attgtatagg agcgtactta gttgaaattg ataatttagg ttataaatcc
     1321 atcaattcta taatggataa ggcaaatatt gcacacaagg taagtaaaac aagaggaatt
     1381 tcctccacag tatggtataa tgaaaatctg ttaaaacagt tacaaatgga aaatagtatt
     1441 tataattata tgtataaagc gatagaaaat gaagaatttc atatgtattt gcaacctaaa
     1501 tttcaaatat cttctttaaa tgttgtaagc gcagaagctc ttgtaagatg gttttctcca
     1561 gaacttggtt ttttatcacc agatgaattt attccattgt ttgaaaaaag tggatttatt
     1621 attgaattgg acttttatat gttaaaaaaa gcgtgttcat ttgtaagaaa aacgtttatg
     1681 aaaaaaaatc aatatacata tccgattgca gttaattttt caagggttac tatttaccaa
     1741 aatagttttt atcaaaggtt tttagatact gttaaagaat atgaaattcc ttttaagtat
     1801 atagagatag aggtaactga aagtgctttt aatgaaatat ctcaaccagt tatttcaatt
     1861 ttagaggaac ttaaaaagtt aggattttta atttcaatgg atgattttgg ttcaggatac
     1921 tcttcattaa gtcttttatg ttctctatct attaatggat tgaagttaga taaaagctta
     1981 cttaaagaaa cctttaaccg ggagaaagta tatagtatta ttcaatgtat tattgaaatg
     2041 tcacatcgta taggcatgtc tgttgtatgt gaaggtattg aaactaaaaa agacttggaa
     2101 tttttaaata cagttaaatg tgatgtagga caagggtttt atttttctaa accgatagaa
     2161 gaaaaagaat tttttaacaa atatgtaact aaaaaataat ataattattt ttatcagtct
     2221 atacattgag tcattttata tctcgttaaa tgactcaatg tactgttatg tattttaaaa
     2281 tataaattat ttaaaacgtt ttttatactt atatagaaat tcttctatat tttttgattg
     2341 ttctcttatt tcaactgctt ctatatctag taaataaagt atagaatcat ttgtaagttc
     2401 aacatattca ccatcttctg aaccgagtgc atgtctctca atttttaatc ctttttcttc
     2461 ataatatttt tttgtttcta tatataatga ttctcgcttt tgtatgtagt ctttcacttc
     2521 attatttgga aagttatatg aatccactaa tgtttcgcca tttataaaag ttttctcggt
     2581 agcaactttt tcatcccaac aatggatttc ttcccaagta aaaaatatct cagttccatc
     2641 tggaatgaat gaaaacctgg taataatata taaataatta ttgaaattta cttcataata
     2701 ttcaggaata tcttcaaatt ccatatagta atttgtataa ttaaaattac tattatcttt
     2761 ttttacaaag ggtatttttg caataaattt atatattgat tgttcatttt taaaaattcc
     2821 tatatcataa cttttttcaa attgattaat tttt
//
LOCUS       DAEQCW010000211         2854 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.212, whole genome shotgun sequence.
ACCESSION   DAEQCW010000211 DAEQCW010000000
VERSION     DAEQCW010000211.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2854)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.212"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            373..627
                     /locus_tag="KRO40_003561"
     CDS             373..627
                     /locus_tag="KRO40_003561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094353.1"
                     /translation="MENKDIKLTICIFAFVIGIIVLFCCIGLGQFNMDCIIKQNGGSI
                     ATEQYNIYLEQSISQYRNFGSILVLLGGIGILFDKSVRKY"
     gene            663..986
                     /locus_tag="KRO40_003562"
     CDS             663..986
                     /locus_tag="KRO40_003562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094354.1"
                     /translation="MARDVFSVKMTPLEAQKMVEKNLEADLVSVDIYNLENNKSIIVT
                     IFEKYYARSNSDAGLVVICENTTGKTLVKITSTGSAIGLFQIDWGTGNNLIKRVKKIL
                     IDYII"
     gene            1260..1412
                     /locus_tag="KRO40_003563"
     CDS             1260..1412
                     /locus_tag="KRO40_003563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094355.1"
                     /translation="MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINF
                     KYHRKK"
     gene            1606..2529
                     /locus_tag="KRO40_003564"
     CDS             1606..2529
                     /locus_tag="KRO40_003564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SHOCT domain-containing protein"
                     /protein_id="HBH2094356.1"
                     /translation="MVGAFVLPNYAIILSEMSNLWGNFIMWILVPIITIVLLIIAVSS
                     MQYILVMIAFLLIIYSFIEKKIVMGLVSVLFFTYSIYLCATWEDKSLIADNKVETVRA
                     QRETVEREKEMERRRIQEEVDKERYIEKHGMEISENDLKVKLEALVPQEYKGKKYELK
                     VGKFKRYSMYFDLTVQNEKFSNSEECKKFVKEIANDLKKIKISKAYFKFHSKDDGGIY
                     NSVYIDYFRNIQNNVDNVENLEFNEFELKTEEEEKREQEKIEQEKNSYNNYIQNRVVD
                     PLDRIKKLKELLDSGAITQEEYNKKKKELLE"
BASE COUNT         1170 a          250 c          505 g          929 t
ORIGIN      
        1 ttagtatgca aaattctgtg aagcaggaaa cctgtgactt tagtcatggg aggttcaggc
       61 tagtattact cattattgta ttcaaaagct aaagtggaaa cctagtgaat atatgaattt
      121 agaagttaat gagagagcat tagcagccga ctcaatactt attaaaattg aagatgaaga
      181 agaaacaatg aaagaagctg aaagagagaa aaagagaggt agaagaaggt agaatttaaa
      241 gttaaaatag ttacattgct aatatatgaa aatgttacaa atttggaaat agatggatat
      301 atatgttgta tagtataatg tagataatat atcaccaagt aaaaaacaac aaataaatct
      361 aaattatgag gggtggaaaa taaagatatt aaacttacaa tatgtatatt tgcttttgta
      421 attggaataa tagtgttatt ttgctgtata ggtctaggtc aatttaatat ggattgtatt
      481 ataaaacaaa atggtgggtc aatagctacc gaacaataca acatatattt agaacaatct
      541 atttcacaat atagaaattt tggttctata ctggttttac taggaggaat aggaatactg
      601 tttgataaaa gtgtcagaaa atactaaaaa agtatatttt tatttaggat gtgatgaatg
      661 atatggcaag agatgtattt agtgtaaaga tgacaccact agaagcacag aaaatggtag
      721 aaaaaaattt ggaagcagat ttagtttctg ttgatattta taacctagaa aataataagt
      781 ctataatagt tacaatcttt gaaaaatatt atgcaagaag caatagtgat gcaggtttgg
      841 tagtgatttg tgaaaatact acaggaaaaa cacttgttaa aattacctca actggtagtg
      901 caattggact atttcagatt gattggggaa caggtaataa tttgattaaa agagtaaaaa
      961 aaatacttat tgattatatt atttaattat tttatgtaga tattcttagg ttggtatgga
     1021 atttgtacta acctattaag taatcaataa aactaaataa acatagaaag cacttacaaa
     1081 tatgtaggtg ctttttattg aaaaaataga aaataaaata aaaagtaaga tataggaaaa
     1141 atatgtaaga attatatgtt ataataattg tagcaagaag atgtaatcta caatttatag
     1201 agtggagttc atgtattaaa aaattatcct cccaacgata agaagggagg tgaatataca
     1261 tggataattt tttatttaat gtgttagcta gtgtaacagc tagttacata gtttatttga
     1321 ttagcaagtt aatcaaaaaa gtaaaaagcc actctaccgc aaagagtgac ttaaagattg
     1381 atataaattt taaatatcat cgtaaaaaat aactttcagt tatagaactt cactctaccg
     1441 caaatagatt gtagttcttc ttgtttttat tataccacaa attagaaaaa atattgcata
     1501 taatattttt tatagtcaat aaaaatatga aattttttat acacaatgat gatgaatcta
     1561 actagatgaa taaatttaat tgtaaataag aaagtactta cttaaatggt aggtgctttt
     1621 gttttgccaa attatgctat aatattgagt gagatgagta atttgtgggg gaattttata
     1681 atgtggatat tagtaccaat aataacaata gtattactta taatagctgt ttcttctatg
     1741 caatatattt tagttatgat agcttttttg ttgattatat attcttttat agaaaagaaa
     1801 atagttatgg gtcttgtgtc agttcttttt ttcacttatt caatttatct ttgtgcaact
     1861 tgggaagata aatccttgat agcagataat aaagttgaga ctgttagggc acaaagagaa
     1921 actgtagaaa gagaaaaaga aatggaaaga agaagaatac aagaagaagt agacaaagaa
     1981 agatatattg aaaaacatgg aatggaaata tcagaaaatg atttaaaagt taagctagag
     2041 gctttagtac ctcaagaata taaggggaag aaatatgaat taaaagtagg aaaatttaaa
     2101 agatatagta tgtattttga tttaactgta caaaatgaaa aatttagtaa ttctgaagaa
     2161 tgtaaaaaat ttgtaaaaga aattgctaat gatcttaaaa aaattaaaat aagcaaggcg
     2221 tactttaagt ttcattcaaa agatgacggc ggtatatata attctgttta tattgattat
     2281 tttagaaaca tacaaaataa tgtagataat gttgaaaatt tagaattcaa tgagtttgaa
     2341 cttaaaaccg aagaagaaga gaagcgagaa caagagaaaa tagaacaaga aaaaaacagt
     2401 tataataact acattcaaaa cagagtggtt gacccactag atagaataaa gaaactaaaa
     2461 gagttgctag attcaggagc aattacacag gaagaatata ataaaaagaa aaaagaatta
     2521 ttagaataga taatatagta agcacttaca agtatgtagg tgcttttaaa tttacaaagt
     2581 attccatttt aattttatag tttagatttt atgatataat aaaaatatag aagttttgca
     2641 gtgtgcgata tttgttacaa agtagggctt aatacttgaa atctaagatg ttgagggtgc
     2701 gtgataagtg ttatcaattg cactattgcc cgctcactgc aattttaaga gtattgtata
     2761 tatgtaggta ttggaaatgc taagtttatt ttggggtttt agattaacta tatggaatgt
     2821 aaatattaca tgggtaaaaa ttttgatgat tttt
//
LOCUS       DAEQCW010000212         2820 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.213, whole genome shotgun sequence.
ACCESSION   DAEQCW010000212 DAEQCW010000000
VERSION     DAEQCW010000212.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2820)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.213"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(400..1107)
                     /locus_tag="KRO40_003565"
     CDS             complement(400..1107)
                     /locus_tag="KRO40_003565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBH2094357.1"
                     /translation="MIFTKSNKYDKDFLMKNMMGPNCIKILEELTSKIKLEKGMRILD
                     LGCGKGISSIFLAKEFDATVFATDLWIEPTENYKRFKEFKLDDKIFPIQAEAHELPYA
                     EGFFDAVISIDSYHYFGNKEGFLDNHISPLVKEGGILAMAMPGLKEDFVDCIPDELIP
                     FWQDNMNFHSITWWNKLWSESESVIVEKCEALNCHDEAWKDWINCDNSYAINDKKMME
                     VENGKYFNTISLIARTK"
     gene            complement(1910..2779)
                     /locus_tag="KRO40_003566"
     CDS             complement(1910..2779)
                     /locus_tag="KRO40_003566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBH2094358.1"
                     /translation="MVIIKAIELYKKLDLEFNIKNINDDWSFMNFENDFITPEFRKKY
                     IGLVLDNAQNINKVYTTTFPDKEIIKQVIDKDEKDILIFSHHAMGYIASDEGFPFHDI
                     PLSYMEEMKNRRISFYVLHSPLDNYSDYSTSVSFAKALGLEIVKPFCKYDDKIEVGVI
                     CKTSLKSIEEIKELIKKSVGHDVKLYDYGDSVLKDGLVAIAAGGGSYPFVAREVAELG
                     INLYITGFTKPLKHFEPVLEFHQIAKDNLINVIGATHYSTEKFACMGMVDYFKNLGLE
                     SEFLQGKYYLEDL"
BASE COUNT          989 a          454 c          247 g         1130 t
ORIGIN      
        1 cttaatcatt ttgaaatttg atttaaagta taataaaata tataaaaaaa tatataaaat
       61 ggtactataa aatttttaat cttcatcaat accttttttg ctttcattgt taaaactatt
      121 ttttctatta gtttatttct tataaaacaa acatttagta ttaaaatata tatcacacaa
      181 tagtatttgc aatttaactt taaaaaataa aaatacccaa ctgacctaag caactcgatt
      241 gggtataaat aatctaaaaa atcatttttg tataaactct ttatttaact tacattttta
      301 tttaccttct actttaattc aacttatatt tctatgcttc ttatactctc attcaactta
      361 tatttctatg cttcttatac ttttataaat tcatcacaat tatttagttc tcgctatcaa
      421 agaaattgta ttaaaatact ttccattctc tacttccatc atttttttgt catttatagc
      481 atatgaatta tcacaattta tccaatcctt ccaagcttca tcatgacaat ttaaagcttc
      541 acatttctct acaatcacag actccgattc agaccaaagt ttattccacc atgtaattga
      601 atggaagttc atattatctt gccaaaatgg aatgagttca tctggtatac aatccacgaa
      661 atcttctttt aatccaggca ttgccatagc aagtattccc ccctctttta caagaggtga
      721 tatatgattg tctaaaaatc cttctttgtt tccaaaatag tgataagaat cgatacttat
      781 caccgcatca aagaaacctt ctgcataagg tagttcatgt gcctctgcct gtattggaaa
      841 tattttatca tccaatttaa actctttaaa tcttttatag ttttcagttg gttctatcca
      901 taaatctgtt gcaaatacag tagcatcaaa ttcctttgct aaaaatatcg aagatatacc
      961 tttaccacaa cctaagtcta aaatacgcat tcccttttct agttttatct tacttgttaa
     1021 ttcttccaat atttttatac aattaggtcc catcatattt ttcatgagaa agtccttatc
     1081 gtatttatta ctttttgtaa atatcattct atctttcctt tccctatcag ttattattta
     1141 ttaaatttta tacgtttgat tttttatttt ttatatgctt cttatattga gcaatctctt
     1201 ttttattcat tctttaacag acaattttaa tgtgtaattt tatccactct gtgatagtaa
     1261 ctttaatgaa taatcttatc tactgtgata gttattttag tgagtaattt tatctactcc
     1321 acagcaatcg ctttaatgag taatcttatc cactctatga tagttatttt agtgagtaat
     1381 tttatctact ccacagtaat cgctttaatg agtaatctta tccactctat aatagtcact
     1441 ttaatgagta atcataattt ttatatcatt ttagatactt actctaataa gaagtcattt
     1501 tctaatactt aataagtttt aattacttcc actttaacct atatactaat taacttattt
     1561 aatttagtgc atatttgaca ctttaccttt tattatacca tttattatca taaatataat
     1621 aattctattt ttttaaaata aatatttata ataatctaaa ataaatattt ataaattcta
     1681 atcaatcgta aataataatc taaaatacat caaaaaataa actaaaaaat atcgaaaaat
     1741 aatttaaaag acatcaaaac taaatcttct aatcagcaat taaaagtcta ttttcttagt
     1801 ttaaaaaata aagatagatt ttttaaaaac actggataaa taggtaaaaa aataaacagt
     1861 tagtaaaata aatttttact aactgtttat ttttattgtt taatatgtcc tataaatcct
     1921 ctaagtaata ctttccttgc aaaaattctg attctaaacc tagattttta aaataatcaa
     1981 ccatgcccat acacgcaaat ttttctgtag aataatgagt agcacctata acattaatta
     2041 aattatcttt tgctatttga tggaactcta atactggttc aaaatgtttt aaaggcttag
     2101 taaacccagt aatatataga tttataccaa gttcagcaac ttctcttgct acaaatggat
     2161 aacttcctcc ccctgctgca atagcaacta aaccatcttt taatacagaa tctccataat
     2221 catacaattt cacatcatga ccaacagatt ttttaattaa ttccttaatc tcttctattg
     2281 attttagtga tgttttacat ataactccta cctcaatttt atcgtcatat ttacaaaatg
     2341 gtttgactat ttctaaaccc agagcttttg caaaactaac agaagttgaa tagtcactat
     2401 agttgtctag tggagaatgt aatacataaa aagaaattct acgatttttc atctcttcca
     2461 tataagatag tggtatgtcg tgaaatggaa aaccttcatc tgatgctatg tatcccattg
     2521 catgatgtga aaaaattaaa atatcttttt catctttatc tataacttgc ttaattattt
     2581 ctttatcagg aaaagtagtt gtgtatactt tattaatatt ttgagcatta tctaatacta
     2641 atcctatgta tttttttcta aattctggag taataaaatc attttcaaaa ttcataaaac
     2701 tccaatcatc attaatattt ttaatattaa attctaaatc taatttttta taaagttcaa
     2761 ttgccttaat aataaccact cctttataat aatattgaat tactacatat taatatagaa
//
LOCUS       DAEQCW010000213         2817 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.214, whole genome shotgun sequence.
ACCESSION   DAEQCW010000213 DAEQCW010000000
VERSION     DAEQCW010000213.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2817)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.214"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            135..575
                     /locus_tag="KRO40_003567"
     CDS             135..575
                     /locus_tag="KRO40_003567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBH2094359.1"
                     /translation="MSDKELSILLLESMNNFHNLIKIINNERYKKDKVLTERQFFALV
                     KIRKHDKIELKNLSRDLHVSTSSLCILLNKLVEQEYVYREEDSRDRRNTFYGITKNGE
                     KILDNEILKFVSIISDKMDCLDIDNKDKLFTSLEESKNIIEQLF"
     gene            591..2042
                     /locus_tag="KRO40_003568"
     CDS             591..2042
                     /locus_tag="KRO40_003568"
                     /EC_number="3.4.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucyl aminopeptidase"
                     /protein_id="HBH2094360.1"
                     /translation="MNIKYSKEILKSLENAITVVALFEGEDVFTTFDKINMISRNFNS
                     KENSIDTVTLIENNNLVNVCFVGFGKRELLNREKIRIIGGNLCKKLKNILKNEAYKSS
                     DVNVLNLNLNSDEIGCFVEGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQI
                     EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMD
                     AFFAVSRGSINKPRFIVMRYFGDKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTD
                     MAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDIISSMAKKTIEVLNT
                     DAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALTLLGNVATPIVTNNDDFYCELEK
                     AATLSGERVWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHM
                     DIAGTSTSSKSIGYKAKGATGEPVRTLYYLAEI"
     gene            complement(2133..2801)
                     /locus_tag="KRO40_003569"
     CDS             complement(2133..2801)
                     /locus_tag="KRO40_003569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YwaF family protein"
                     /protein_id="HBH2094361.1"
                     /translation="MFKIFLFSSEQFVSLFIFGLFLYYCPKLTKNILPYSYTVEKIIC
                     TLLVIIMALEQLLLISSGNYSTLNSLPIGINYICIYLCIAILIFKQYHLFNIFFSWSL
                     VCSVGELIFSKNLGYEFPSLIYFIFIFSKCLIIYADIYMVDVRKFRVNRYALRDNLAI
                     CFIYFSFIFLLNTFTNSRYYYGFLSHSTTAIFTFIFVTSIMYIPALLFNRDTFILEKK
                     KKSK"
BASE COUNT         1167 a          262 c          495 g          893 t
ORIGIN      
        1 aaaacaattt aaatagataa taaagttgat atatagtata attataaaaa gaaaagaagt
       61 attatattat agatatataa acgcatttga gatataagag ggagttataa atcattagtt
      121 ttgaggtgaa tgttatgagc gataaagaat tatctatttt gttgttagaa agtatgaata
      181 attttcataa tttaataaag attattaata acgaaagata taaaaaagat aaggttctta
      241 cagaaagaca gttctttgcc ttagtaaaaa taagaaaaca tgataaaata gagcttaaaa
      301 atctaagtag agatttgcat gtatctactt ctagtctgtg tatactactt aataaattgg
      361 ttgagcaaga gtatgtatat agggaagaag atagtagaga tagacgaaat actttttatg
      421 gaataactaa aaatggagaa aagatattgg ataatgaaat actaaagttt gtatctataa
      481 taagtgataa aatggattgc ctagatatag ataataaaga taaattattt acttctttgg
      541 aagagtctaa aaatataata gaacaattat tttaaaaagg agaatttatt atgaatataa
      601 agtattctaa agagatatta aaaagtttag aaaatgctat aacagtagta gctctatttg
      661 agggagaaga tgtttttacg acatttgata aaataaatat gataagcaga aattttaatt
      721 ctaaagaaaa tagtatagat actgtaacat taattgaaaa taacaatttg gtaaatgttt
      781 gttttgttgg ttttggtaag agagagttat tgaatagaga aaaaattaga atcataggtg
      841 ggaatttgtg taaaaaatta aaaaatatat tgaaaaatga agcatataag agtagtgatg
      901 ttaatgtact gaatcttaat ttaaatagtg atgaaatagg ttgttttgta gaagggatat
      961 tacttggaaa ttataagttt gataagtata agacaaaaag taaggatttt gaaagaaaag
     1021 aagttgatac tataactata tttactgaaa aagaagttga gtgtcaaata gaaaaggcta
     1081 aaatattagc taattcaact ataatagcta gaaatctagt taatgaacca tcaaacgtaa
     1141 tatatccaaa aacattagca gtagaaacag ttaaacttgg tgcagagttt gggtttaatg
     1201 ttgatgttta tgaagaagaa aaaataaagg cattgggaat ggatgctttt ttcgctgttt
     1261 caagaggttc aattaataaa ccaagattca tagtaatgag atactttgga gataaagaaa
     1321 gtacagatat attaggtcta gtaggtaaag gattgactta tgatactggt ggatattctt
     1381 taaaatcaaa tgcttctatg ctagatatga agacagatat ggctggtgct gcgagtgtta
     1441 taggtgctat gtgtgctata tctcaaagta aattaaagaa aaatgttata gcagtagtgg
     1501 ctgcatgtga gaatgcttta tcaggaggtt catacaaacc tggagatata attagttcta
     1561 tggcaaagaa aactattgaa gttttaaata cggatgcaga aggtagactt acattagctg
     1621 atgcaatata ctacattata aacaatgaaa aagtaacaaa ggtggttgat gtagctacat
     1681 taactggtgc tgctttaaca ttgttaggta atgttgcaac tcctatagta acaaataatg
     1741 atgattttta ttgtgaatta gaaaaagctg ccactttatc aggggaaagg gtatggaaga
     1801 tgccaattta tgatgaattt aaagatatga taaaaggaga agaagcagac cttaaaaaca
     1861 ctggtggtaa aaatgctgga tgtataacag caggagcttt tattggtgaa tttgttggga
     1921 atactccttg gatacatatg gatatagcgg ggacaagtac atcatcaaaa tcaattggat
     1981 acaaagcaaa gggggctaca ggagaacctg ttagaacatt gtactatttg gcagaaatct
     2041 aaaaaacaat tataaaatat aatttataaa gccacgtgga tatttttgta atttaagatt
     2101 atctatgtgg ctttattttt tatttaagta aattatttac tctttttctt tttttcaagt
     2161 ataaaagtat ctctattaaa taaaagagca ggtatgtaca taatactagt aacaaaaata
     2221 aacgtaaaaa tagcagttgt gctatgactt aaaaaaccat aatagtacct agagttggta
     2281 aatgtgttta gtaaaaatat gaatgaaaaa taaataaaac atatagctaa gttatctcta
     2341 agtgcatatc tgttaactct aaattttcta acatcaacca tatatatatc tgcataaatt
     2401 atcaagcact tagagaagat aaagataaaa tatattaagc taggaaattc atagcccaag
     2461 tttttagaaa aaatgagttc tccaactgaa caaactaaac tccaagaaaa aaatatatta
     2521 aaaagatgat actgcttaaa aattagtatg gctatacaca gatatataca aatataattg
     2581 attccaattg gtaaagagtt tagagtacta taattacctg aagaaataag taataattgc
     2641 tctagagcca taattattac aagtaatgta caaattatct tctcaactgt atagctataa
     2701 ggtaaaatat ttttggttag ttttggacaa tagtataaaa ataatccaaa tataaagaga
     2761 cttacaaatt gttcactaga aaaaagaaaa attttaaaca tataacattc tctccta
//
LOCUS       DAEQCW010000214         2793 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.215, whole genome shotgun sequence.
ACCESSION   DAEQCW010000214 DAEQCW010000000
VERSION     DAEQCW010000214.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2793)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.215"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            185..388
                     /locus_tag="KRO40_003570"
     CDS             185..388
                     /locus_tag="KRO40_003570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBH2094362.1"
                     /translation="MISYAPLWKLLIDRKIKKMEFVNISGISISVLGRLGNDKSVSMD
                     TMEKICLALDCKIEDVVEIKKSI"
     gene            552..1706
                     /locus_tag="KRO40_003571"
     CDS             552..1706
                     /locus_tag="KRO40_003571"
                     /EC_number="1.1.1.267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="HBH2094363.1"
                     /translation="MKKISILGSTGSIGKQTLDVVRDNRDKFEIVAISANSNIELLLE
                     QIVEFKPKYVTVFEENKALKLKEMLPKNIEIEVLAGMEGLKIISSLDEVDVLLTAVVG
                     MIGLVPTLCAIKKGIDIALANKETLVTAGELVMKEAEKYNVNILPVDSEHSAIFQCLN
                     GENKKNIEKIILTASGGPFRGKKKGELANITKNEALKHPNWSMGRKISIDSSTLMNKG
                     LEVIEARWLFGVEQENIDVVVHPQSIIHSMVQYTDSSIIAQLGCPDMRLPIQYALTYP
                     DRMESSFERMNFSKFSTLTFEEPDLETFPCLKLAYECLKMGGTYSSVLNSANEVLVSE
                     FLEDKIGFYDIPYYIEKTLEVHSSISEPTLEEILETDRWSRAYVANLIKK"
     gene            1719..2723
                     /gene="rseP"
                     /locus_tag="KRO40_003572"
     CDS             1719..2723
                     /gene="rseP"
                     /locus_tag="KRO40_003572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HBH2094364.1"
                     /translation="MTIIAALILFSIIVLIHELGHFIFAKRSGIKVNEFSIGMGPKIY
                     SVKKDTEYSIRALPIGGYVSMEGEDEEQISPNSFGNKSILQRFSTIVAGPIFNIILAA
                     ILLVPVFLYIGSPTTKLGKIMPDTPAQAVGLQVGDKINKINGNSVKTWDEVANIINTS
                     SGGELKLSITRDGSDKVVNVTPKNNNGKYEIGIQPQREKDFLGSIVNACKTTVDMTKQ
                     MLTFLGQMITGRVPGGIGNAVAGPVGVIGMVSDAARTGIINVVYLAAVISLNLGIVNL
                     LPIPALDGWRILMLLLEAVRGGKKLDPNKEGMINVVGFGALMLFMLFITYKDILRLFQ
                     "
BASE COUNT         1099 a          284 c          522 g          888 t
ORIGIN      
        1 aaaataatga gataaatata tataaagttt aatttttgaa cttatgcttt tgttttattt
       61 taacatattt atatttaata aactataatt gaaatctatt tagataaata attatttatc
      121 taaatagatg aaaattttcc aaaatagata aaatgtgata gaatatattt tgcgaggtga
      181 taacatgatt tcatacgctc cattatggaa attgttaatt gacagaaaaa taaagaaaat
      241 ggaatttgta aatatatcag gtataagtat ttctgtttta ggcagactag gaaatgataa
      301 atctgtttct atggatacaa tggagaagat atgtttagca ctagactgta aaatagaaga
      361 tgttgtggaa ataaaaaaga gcatttaata atactagaat attttataat attccacaaa
      421 atacaaaaaa taatagatta attttaatct gtggaataat atatgaaatt tctatgaata
      481 gtaaaaataa ttgttttagt agtgttataa tgttttgaca gggtatattt attattagaa
      541 aggattatta tatgaaaaag atatcaattt taggttctac aggctctata ggtaaacaaa
      601 ctttggatgt agttagagat aatagagata agtttgagat agttgcaata tcagctaaca
      661 gtaatattga attattgcta gaacagatag tagagtttaa acctaaatat gtaacagttt
      721 ttgaggaaaa taaagcattg aaattaaaag aaatgttgcc taaaaatata gaaatagaag
      781 ttttagcagg aatggaagga ttaaaaataa tatcatcact tgatgaagtg gatgtccttt
      841 taactgctgt agtaggtatg ataggattag tcccaactct ttgtgctata aagaagggaa
      901 tagacatagc attagcgaat aaagaaacgt tggtaactgc tggtgaactt gtaatgaaag
      961 aagcagaaaa atacaatgta aatattcttc ctgttgatag tgaacatagt gctatatttc
     1021 aatgtctaaa tggagaaaat aaaaaaaata tagaaaagat aatacttaca gcatctggtg
     1081 gtccatttag aggaaagaaa aagggagaac ttgcaaatat aactaaaaat gaagctttga
     1141 agcatccaaa ttggagtatg ggaagaaaaa taagtattga ttcttcaacg cttatgaata
     1201 aaggacttga agtgatagaa gctagatggt tatttggagt agaacaagaa aatatagatg
     1261 tagtagttca cccacaaagc ataattcatt caatggtgca gtatacagat agctcaataa
     1321 ttgctcaatt aggatgtcca gatatgagac taccaataca gtatgctctt acatatccag
     1381 atagaatgga aagtagcttt gaaagaatga atttttcaaa atttagtact ttaacttttg
     1441 aagaaccaga tttagaaact tttccatgtt taaaattggc atatgagtgt ttaaaaatgg
     1501 gaggaactta ttcctctgtt ttaaattcag caaatgaagt tttagtaagt gaatttttag
     1561 aggataaaat tggtttctat gacataccat attacataga gaagacttta gaagttcata
     1621 gtagcataag tgaaccaaca ttagaagaaa tcttagaaac agatagatgg agtagagctt
     1681 atgttgcaaa tctgataaaa aaataggaag gtgaatttat gactataata gccgcattaa
     1741 tactatttag tataattgta ttaatacatg agttaggaca ttttatattt gcaaaaagaa
     1801 gtggtatcaa agtaaatgag ttttctatag gtatggggcc taagatatat agtgtaaaaa
     1861 aagatacaga gtattctata agagcacttc caattggtgg atatgtcagc atggaaggtg
     1921 aagatgaaga acaaataagt ccaaattctt ttggaaacaa gtctatatta caaagattta
     1981 gtactattgt agcaggacca atattcaata taatattagc agcaatactt ttagttccag
     2041 tatttttgta tataggttct ccaacgacta aattaggaaa gataatgcca gatactcctg
     2101 cacaggctgt agggcttcaa gtaggagata agataaataa aattaatggt aattctgtta
     2161 agacttggga tgaagttgca aatataataa atacttcttc tggtggagaa ttaaaactta
     2221 gtataactag agatggaagt gataaagttg taaatgtaac acctaaaaat aacaatggaa
     2281 agtatgaaat agggattcaa ccacaaagag aaaaagactt tttggggtca atagtaaatg
     2341 catgtaaaac tactgtagat atgacaaaac agatgctaac atttctaggt caaatgatta
     2401 caggacgtgt accaggaggg attggcaatg ctgtagcagg accagtaggt gttattggta
     2461 tggtatcaga tgctgctcgt acaggcatca taaatgtagt gtatttagca gctgtcataa
     2521 gcttaaattt aggtatagta aatctattac caataccagc acttgatgga tggagaatac
     2581 ttatgctgtt actagaagct gttagaggtg gtaaaaaact cgacccaaat aaagaaggca
     2641 tgataaatgt tgttggtttt ggagctttaa tgttatttat gctttttatc acatataaag
     2701 atatactaag attatttcaa tgatttagtt tttagagatt ttaagaaaat aggctatgta
     2761 gttttaaata agaataaatt aatttttata tat
//
LOCUS       DAEQCW010000215         2760 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.216, whole genome shotgun sequence.
ACCESSION   DAEQCW010000215 DAEQCW010000000
VERSION     DAEQCW010000215.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2760)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.216"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            299..2434
                     /gene="rnr"
                     /locus_tag="KRO40_003573"
     CDS             299..2434
                     /gene="rnr"
                     /locus_tag="KRO40_003573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HBH2094365.1"
                     /translation="MIPGLKESLLGLINESAYNPLKKEELAEIFDIHSSEMPMFYNFL
                     NELEEDGYICFTKKGKIVSPNQMGYFVGKFVSHKKGFGFVESDVEYTQDLFISSDNIN
                     GAMHNDRVMAEIVVPATEEKRAEGRIVKVIKREITRIVGTFQSSKTFGFVTPDNKKFT
                     KDIYIPKKHFSGAVDNDKVVCEITVWPQEDRKPEGKIIEILGQKGERGVEIDSIIREH
                     GLPEEFPKKVLQEAEAVAVEIPQEEIKRRRDLRDLNIFTIDGDDAKDLDDAISIEVLP
                     NGNFKLGVHIADVTHYVREKNKLDKEALKRATSVYLVDKVIPMLPKTLSNGVCSLNPF
                     EDKLTLSIFMEIDHKGNVVKHEICESVINSKARMTYTEVSDILEKDDEKLKKTFEHVV
                     EDFKNAEILARILMSRREKRGAIDFNFPEAKIILNGKGEVVDIKPYERRISNKIIEEF
                     MLISNETIAEHFYWMGIPFVYRIHETPSLEKMEELSKFISTFGYIIKGDKEEVHPKAL
                     QGIIEKIKGKKEEGAISTIMLRSLKQAKYSPECSGHFGLAAKFYCHFTSPIRRYPDLQ
                     IHRIIKESLNNKISGKRQEQLTTIVDYASVQSSEKERKAELAERDVHDFYKALYMKDK
                     VGQEFEGVVSSVTSFGIFVELDNTIEGLIRLANMNDDYYIYDESSYSVLGERTKKSYK
                     IGDLVKIKVESVNVDFKEIDFEIVEKIEE"
BASE COUNT         1204 a          263 c          506 g          787 t
ORIGIN      
        1 taccaatcct atttgatggt gtataattag gtgataaaga gtaatttaag caattatgat
       61 aaagaataac ttaagtaatt ataatgatat ttacaaataa tttataaaac ataataattt
      121 gtttgaagtt agtatgacaa agcttacatt aaatcaaaaa tataaataag taattttaac
      181 ttgtaataat aataaggaaa tatagaaaat tatgtgataa gtaaaaaatg ttttgtctga
      241 agaaatataa aagacaatat aaataataat ataatgaaaa gtaaaacagg agggaaaaat
      301 gataccagga cttaaagaaa gtttgctagg attaataaat gaaagtgcat ataatcctct
      361 aaaaaaagaa gaattagcag aaatatttga tatacattca tcagaaatgc caatgtttta
      421 taatttttta aatgaattag aagaagatgg ttatatctgc tttactaaaa aaggaaaaat
      481 agtatctccc aatcaaatgg gatactttgt tggaaaattt gtatcacaca aaaagggttt
      541 tggatttgta gaatctgatg ttgaatatac acaggattta tttatctcaa gtgacaatat
      601 aaatggtgct atgcataatg atagagttat ggcagaaata gtagtacctg caactgaaga
      661 aaagagagca gaaggaagaa tagtaaaagt aataaagaga gaaataacta gaatagtagg
      721 taccttccaa tcaagtaaaa cttttggatt tgtaacacca gacaacaaga aatttactaa
      781 agatatatat atacctaaaa aacattttag tggagcagta gataatgata aggtagtatg
      841 tgaaattaca gtatggccac aagaggatag aaaaccggaa ggcaaaatta tagagatact
      901 aggtcaaaaa ggtgaaagag gcgtagaaat agattctata ataagagaac atggtcttcc
      961 agaagaattt ccaaagaaag tattgcaaga agcagaagct gtagctgttg agattcctca
     1021 agaagagata aaaagaagaa gagatttaag agatttaaac atatttacta tagatggaga
     1081 tgacgcaaaa gacttagatg atgccatatc aatagaagta ttacctaatg gaaacttcaa
     1141 actaggagtt cacatagctg atgttacaca ttatgtaaga gagaaaaata aacttgacaa
     1201 ggaagcctta aaaagagcta catcagttta tttagtagat aaagtaattc caatgttgcc
     1261 aaaaactctt tcaaatggag tatgtagctt aaatccattt gaagataagt taactctttc
     1321 tatatttatg gaaatagacc ataaaggaaa tgtggttaaa catgaaatat gtgaatctgt
     1381 aataaattca aaagctagaa tgacttatac agaagtatct gatatattag aaaaagatga
     1441 tgaaaaactt aaaaagactt ttgaacatgt tgttgaagat tttaaaaatg ctgaaatttt
     1501 agctaggatt cttatgtcaa gaagggaaaa aagaggagct atagacttca attttccaga
     1561 ggcaaagata attctaaatg gaaaaggcga agttgtagat ataaagccat atgaaagaag
     1621 aatatctaat aagataatag aagaatttat gcttataagt aatgagacaa ttgccgaaca
     1681 tttttactgg atgggaatac cgtttgtgta tagaatacat gagacaccat ctttggaaaa
     1741 aatggaagaa ttgagtaagt ttatatctac atttggatat ataataaaag gtgataaaga
     1801 ggaagtacat ccaaaagcat tacaaggtat aatagagaaa ataaagggca aaaaagaaga
     1861 aggagctatc agtactataa tgcttcgttc tttaaaacaa gctaagtact caccagaatg
     1921 tagtggacat tttggattag cagctaaatt ctactgtcac tttacttcac caataagaag
     1981 atatcctgac cttcaaattc atagaataat aaaagaatct ttaaataata aaataagtgg
     2041 aaaaagacaa gaacagctta ctactatagt ggattatgca tctgttcaat catccgagaa
     2101 agaaagaaag gcagagttag ctgaaagaga tgtacatgat ttctataagg ctctttatat
     2161 gaaggataaa gttggtcaag aatttgaggg tgttgtatct agcgtaactt catttggaat
     2221 atttgttgag ttagataata ctatagaagg attgataaga cttgcaaata tgaatgatga
     2281 ttactatatt tatgatgaga gttcttatag tgttttagga gaaagaacta agaagtcata
     2341 taagatagga gaccttgtta agataaaggt tgaaagtgtt aatgtagatt ttaaagaaat
     2401 tgactttgag atagttgaaa aaatagagga gtagataaaa cagctaaaat aagagataac
     2461 aagttgtagt atttatgata tgtataaata tatagtgcac aatactctat aaaataaatg
     2521 ataaaaatag gtaattgaga aatatctaat ggaaatagtt aactgaaaga taaataatta
     2581 agaaatattt aatgaaagta gctaattgaa aaataagtaa ttgagaaatg tttaatagaa
     2641 agagctaact gaaagataag taattaagaa acatttaata gaaaaagcca actgaaaaat
     2701 aaataattaa gaaatgttta atagaagtgg ctaattgaaa aataagtaat taagaaatgc
//
LOCUS       DAEQCW010000216         2609 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.217, whole genome shotgun sequence.
ACCESSION   DAEQCW010000216 DAEQCW010000000
VERSION     DAEQCW010000216.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2609)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.217"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(115..1500)
                     /locus_tag="KRO40_003574"
     CDS             complement(115..1500)
                     /locus_tag="KRO40_003574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBH2094366.1"
                     /translation="MPINSFENYPMNWKPKRPSKGQILYKALAEQLEQDINNGFLLPG
                     TKLPPQRELADFLDVNVSTISRAFKICEKKGLISGVTGSGTFVSYDTRSNLFLMSSNN
                     KITFIEMGTMNPDFTLEEMNTLFKHIIKEIGFKTIFQYGQRDGAKWQKEAIAKLIYKA
                     GLETTSDSLLPASGGQNAIVAILAGLFQHGDRIGVDPLTYPGIKTAAKMLGIQLIPIK
                     QEDNEISEEGLLYACKNENIKGLYIIPDYQNPTTHIMSQNGRKMIANIASKYNLIVIE
                     DAIHSLLNETHLNPVASYLPNQTIYITSLSKIIAPSLRLAYISTPKQYREALSSALYN
                     INLSQSYFLTEIAYRMITSGEADKLINARRKSARRRNKIINQYLSGYNLLGNEECIFR
                     WLILPDGIMAEKFEIQALKEGVQVYASERFAVGKEKPISAIRIAVCATESTEELKAGL
                     SVLKRLLEEKK"
     gene            complement(1608..>2609)
                     /locus_tag="KRO40_003575"
     CDS             complement(1608..>2609)
                     /locus_tag="KRO40_003575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBH2094367.1"
                     /translation="QGITLDIFMYIWILGIIAISFYYLRTNFKFYNYIENFKKEILEI
                     DITSILDEQAKELSINKKLQIYKVKGIYSPAIIGLTRCKIIIPEKKYNNKELRFIFKH
                     ELIHYKRKDNLFKLLISIICIIYWFNPILYLLKKYFHELCELSCDEIVIDKCTTSEIK
                     EYAYIILDTIKYQKSLKYSSFVSQFLNKKNIILKKRLNSMFNQDKKKINLGLKFLLTF
                     IIIGSIFSINSNFKQNEDVEYTIGKINYNKNGETYGTHIIDSNGNSIEPELIQTIGRG
                     KKVGYVKKRDLYDCDNQPKTPEEAVLYTRKRNFNIFKKTIPLYDKEGIKIIGRFEIN"
BASE COUNT          841 a          387 c          321 g         1060 t
ORIGIN      
        1 gttattatga tgtaataata catattaatc tctataagtt aattactatc tggtgtaatt
       61 ttattttaac aacaaaaaaa aatacacaca attaaaatat tgtgtgcaat acaattattt
      121 tttctcttct aatagtcttt ttaatacgct caaaccagct ttaagttctt ctgtactttc
      181 tgtagcacat acagctattc ttattgcaga aattggtttt tcttttccaa cagcaaaacg
      241 ttcagaagca tagacctgta caccttcttt aagtgcttgt atctcaaatt tttctgccat
      301 tattccatca ggtagaatca accatctaaa tatacattct tcatttccca aaagattata
      361 tccagataaa tattgattaa taatcttgtt tcttcttctt gcagatttac ggcgtgcatt
      421 aattaattta tcggcttcac ctgatgtaat catgcgataa gcaatttctg ttaaaaaata
      481 agattgagat agattaatgt tgtataatgc gcttgataat gcctctcgat actgtttagg
      541 tgtagagata tatgctagcc gtaaactagg tgcaataatt tttgataaac tcgtaatata
      601 aattgtttga ttgggcagat aggaagccac tggatttaaa tgtgtttcat taagtaaact
      661 atgaatagca tcctcaataa caattaaatt gtatttagat gcaatatttg caatcatttt
      721 tcgtccattt tgtgacatta tatgtgtagt tggattttga taatctggta ttatgtatag
      781 acctttaata ttttcatttt tacaagcata taatagtcct tcttcactaa tctcattatc
      841 ttcttgttta attggaatta gttgaatccc aagcatttta gctgctgtct ttattccagg
      901 ataagttaat gggtctacac ctattctatc tccatgttga aacaaaccag ctaaaatagc
      961 aacaattgca ttttgtccac cacttgcagg aagtaagcta tctgatgtag tttcaagccc
     1021 agctttataa attaatttgg caatagcttc tttttgccat ttagcaccat ctctttgtcc
     1081 atattggaat atggttttaa aacctatttc cttaattatg tgtttaaaca aagtattcat
     1141 ttcttctagc gtgaaatctg gattcattgt gcccatttca ataaatgtaa ttttattatt
     1201 actggacatc aagaatagat ttgaacgtgt atcataagat acaaaagttc cacttcctgt
     1261 aactccactt attagacctt ttttttcaca aattttaaaa gctctagaga tagtactcac
     1321 attaacatct aagaaatctg ccaattcacg ttggggtggt aatttagtac ctggtaataa
     1381 aaatccattg ttgatatctt gttctagttg ttctgcaagc gccttatata atatttgccc
     1441 ttttgaaggt ctctttggtt tccagttcat aggataattt tcaaaagaat taattggcat
     1501 aagttttcac ctcacattat taatttgatt ttttctttat ctaaaacaat aaattctaaa
     1561 gatacaaata aaaactgata ggaaataatt ctatcagttt ttgtctttta attgatttca
     1621 aatcttccta taatttttat accttcttta tcataaagag ggattgtttt tttaaatata
     1681 ttaaaatttc tttttcttgt atataaaaca gcttcttctg gtgtctttgg ttgattatca
     1741 caatcgtaca aatctctttt ttttacgtag ccgacttttt tacctctacc tattgtttgt
     1801 ataagttctg gttcaatgga atttccattt gagtctatta tatgtgtacc ataggtttct
     1861 ccatttttat tataattaat cttaccaata gtatattcta catcttcatt ttgtttaaaa
     1921 ttggagttga tagaaaatat tgaccctatt attataaagg ttaataaaaa cttaagacct
     1981 aaattaattt tctttttatc ttgattaaac atagaattta acctcttttt taaaataata
     2041 ttttttttat ttagaaactg agatacgaat gatgaatact tcaaagattt ttgatacttt
     2101 attgtatcta atattatata tgcatactct ttaatttcac tcgtggtaca cttgtcaatc
     2161 acaatttcat cacaagataa ttcacataat tcatgaaaat atttttttaa taagtataaa
     2221 attggattga accaatatat gatacaaatt atactaatta gaagcttaaa taagttatct
     2281 tttcttttat aatgaattaa ttcatgttta aagatgaatc ttaactcttt attattgtac
     2341 tttttttctg gaattattat tttacagcgt gttaaaccta taatggcagg agaataaata
     2401 cctttaacct tatatatctg aagtttttta tttatactta gttcttttgc ttgttcatct
     2461 aagatactag taatatctat ttctaaaatt tcttttttaa aattttctat gtaattataa
     2521 aatttaaaat ttgttcttaa atagtaaaaa gagattgcta taattcctaa tatccagatg
     2581 tacataaata tatctaaagt aatgccctg
//
LOCUS       DAEQCW010000217         2527 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.218, whole genome shotgun sequence.
ACCESSION   DAEQCW010000217 DAEQCW010000000
VERSION     DAEQCW010000217.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2527)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.218"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(797..1834)
                     /locus_tag="KRO40_003576"
     CDS             complement(797..1834)
                     /locus_tag="KRO40_003576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2094368.1"
                     /translation="MIKSKKILSLIIAGVLGVSMLTGCSQNDGSNASNENKETDSKKQ
                     KNIGITQLVEHPSLDKAKKGFIKALEDKGYKDGDNIKIDFQNAQNDMPTTQSIASKFV
                     SDKKDLIYAISTPSAQAAYNATKDIPIIMTAVTDPVEAGLVKSLEKPGGNVSGTSDYL
                     SIDKTLELVKTLTPKAKKIGVIYNTSEVNSKIQVDSLHDYAKKNNYEVVEKGISSSSE
                     VNQAISSLVGKIDVLYVPTDNLIVSSMPIVSKVANENKIPIIASEEGSVSSGALACCG
                     IDYEKLGYKAGELAIEVLEGKSVGDIPVTTLDETEIIINEDTLKALDMQKLSADNIKY
                     IKSDENAKSAK"
     gene            complement(1931..>2527)
                     /locus_tag="KRO40_003577"
     CDS             complement(1931..>2527)
                     /locus_tag="KRO40_003577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003399531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2094369.1"
                     /translation="GLIKESSGQITLDSTTITNLAEYKRTQIVSRVFQDPSLGTCPSM
                     TVRENLSLALNKGKLLNLKKCLRHKTNDLEHLLEGISLDLKKYLDIKVQYLSGGQRQS
                     LSLIMSSLASPKVLLLDEHTAALDPKTSNEVIELTDKIVREKNITTLMVTHNLKHALQ
                     YGDRLIMLHKGEVVLDVKDKEKEDLTVEEILEKFEYAV"
BASE COUNT          828 a          380 c          326 g          993 t
ORIGIN      
        1 cctttgaaaa tatttttata attttaatta tttgctaatt ttgtgtataa aaaaaccaca
       61 tagtgtacaa aactatgtgg taaaaacacg aataagccac atagtttaat ctatgtggct
      121 cttatatagt taaatgaaaa ctttataaac aatatagcca acatagatac aatcccaaaa
      181 ttttagtagt cttaaggggt ctgtatctat gttaaaacgt aggtacaaac cctaaaaata
      241 gtggctataa taataataat attttctatt gtttaataaa gtattcataa ttatctctcc
      301 cttttaatat tttaattagt cagaaaatta tatgtattct cgacttgtta taaattataa
      361 attatacaat aataaaagtc aactgctaaa tttaattaaa atactaaata atgtatactc
      421 agaatacttt taaattaatg tattgtttgc aaaaaacgtt atcctaagtt ataagtgaat
      481 gtggaaattt tatcaaaata tttactagat atggaataac tagacatgta tatcaatcaa
      541 atatcataaa aaaaagctgt ctggagaata ttaaaattct tttggacagc tcaagtagtg
      601 attagaaagt tatataactt tcataatcag tcgtcaatat agacgacttt tatggaaaat
      661 gaataacttt atatgcaata ttcaaattgc tacaataagc acaattttca aagggttagg
      721 gtggataaga gtacttatta tataaagttt tcatattacc tacttcatat tacctatttt
      781 ttgaaattaa taggttttat tttgcagatt ttgcattttc atctgacttt atatacttta
      841 tattatctgc tgataacttt tgcatgtcaa gtgcttttag tgtatcttcg ttaattatta
      901 tttcagtttc atctaatgta gtaactggta tatcgccaac agattttcct tctaatactt
      961 caatagcaag ttctccagcc ttataaccta gtttttcata atctattcca caacaagcta
     1021 aagcaccaga agacacagaa ccttcttcag aggctattat aggaatcttg ttttcattag
     1081 caactttaga aactattggc atagaagaaa ctattaaatt gtcagtaggg acatataaaa
     1141 catctatttt gccaactaaa ctagaaatag cttggttaac ttcacttgaa gagctgattc
     1201 ctttttcaac tacttcataa ttatttttct tagcataatc atgtagagaa tcaacttgga
     1261 tttttgaatt aacttcacta gtattgtata taacccctat tttctttgct tttggagtca
     1321 atgttttaac caattctaat gttttatcaa ttgaaagata atcagatgta ccagaaacat
     1381 ttccacctgg tttttcaaga gatttaacaa gtccagcttc tacagggtct gtaacagcag
     1441 tcattattat cggaatatct ttagtagcat tataagctgc ttgtgcagat ggagtagata
     1501 tagcatatat caaatctttt ttgtcggata caaacttact agcaatactt tgtgtagtag
     1561 gcatatcatt ttgtgcattt tggaaatcta tttttatatt atctccatct ttatagcctt
     1621 tatcttcgag tgctttgatg aatcctttct ttgctttatc cagagatgga tgttccacta
     1681 attgagtaat acctatattt ttttgttttt tgctatctgt ttctttattt tcatttgaag
     1741 cattggagcc atcattttga gaacatccag taagcattga tacaccaagt actcctgcta
     1801 taattaaact taatattttt ttacttttta tcattttatt ttcctccctt aaaatttatt
     1861 aattatattt gttcatatat tcatatgata gattataaat atttctgatt aaaactaaga
     1921 ttttaatttc ttatactgca tattcaaatt tttctaagat ttcttcaact gttaaatctt
     1981 ctttttcttt atcttttaca tctaatacaa cttcaccctt atgaagcatt atcaacctat
     2041 ctccatattg aagagcgtgt ttcaagttgt gagtaaccat aagtgtagtt atatttttct
     2101 ctcttacgat tttatctgtt aactctatta cttcatttga tgtttttggg tcaagtgctg
     2161 ctgtatgttc gtctagtaat aagaccttag gacttgctaa gctagacata attagtgata
     2221 gtgattgtct ttgaccccct gaaagatatt gtactttaat atctaaatat ttttttaaat
     2281 ccaaagaaat tccttcaagt aagtgttcca agtcattcgt tttatgacga agacattttt
     2341 ttaagttcaa taatttccct ttattaagtg ctagagataa attttctcta accgtcatag
     2401 aaggacaagt tccaaggctt gggtcttgaa aaactctact tactatttga gttcttttat
     2461 actcagctaa atttgttata gtagtactat ctaaagtaat ttgaccagaa gattctttta
     2521 taagccc
//
LOCUS       DAEQCW010000218         2526 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.219, whole genome shotgun sequence.
ACCESSION   DAEQCW010000218 DAEQCW010000000
VERSION     DAEQCW010000218.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2526)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.219"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..415
                     /locus_tag="KRO40_003578"
     CDS             <1..415
                     /locus_tag="KRO40_003578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094370.1"
                     /translation="SSKTALYFIELPKIHKSDYIVNRIMLWGKLISNPSSLDVRVIAK
                     NDSIIKKALDRLKELGSNEEYLLNLKRGAYIMNKSRNFKEEIERETAIRVAKEKDYKI
                     IIMLKKNGFKLDDILNKFNDFDLSEDEIKEVYENN"
     gene            1081..2421
                     /locus_tag="KRO40_003579"
     CDS             1081..2421
                     /locus_tag="KRO40_003579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBH2094371.1"
                     /translation="MIKSSLFWNIFIAISFMIEWFLCKKMLDYTSEKRISNKKINFCM
                     VGIIVFADIIYFFDVPPNIRVIISMIITIAFYKISYDVGFIKSVLISLIYWMLLIATD
                     ALSISLTVWLNSINDMSSMGTGDIYRIESIILGKILLIVSLLLYRALKIKLNIEINKR
                     TLFYIVIPIVANIASFFVIFEYIFNPGSGSLIHNFQFVMISVVLLISSITLVLIAKKL
                     QQYNTLVVENNMIKNTLKYENEYYEDIEKKYLKTRLLSHDMKNHILCINAMIKKGIDV
                     TSYLNNLQVEIQSNDLLFNTGNFILDAILSEKKEVCDKNDIELKIGINFSCCEAVELV
                     DICHIFSNILDNAIEACNKIDSGNRVICVKGDVMQNFYLIRVENTKMNKIITKNGDIL
                     TDKKGSLHGLGIKSVKNSVNKYGGNVVIEYDDKKFVVKIAIPLRNVKKAVNHVI"
BASE COUNT         1014 a          186 c          388 g          938 t
ORIGIN      
        1 ttctagtaaa actgcattat attttataga gcttccaaaa attcataaat ctgactatat
       61 agtaaataga attatgctat ggggaaaact tattagtaat ccttctagct tagatgtaag
      121 agttatagct aagaatgatt ctattattaa aaaagcactt gatagattaa aagaattagg
      181 tagcaatgaa gaatatttat taaatctgaa aagaggtgct tatatcatga ataaaagtag
      241 aaattttaaa gaagagattg aaagagagac agcaattaga gttgcaaaag aaaaagatta
      301 taaaataatt ataatgttga aaaaaaatgg ttttaaatta gatgacatat taaataaatt
      361 taatgatttt gacttaagtg aagatgagat aaaagaagta tatgaaaata attgatgata
      421 aaaagtgaac ttatataagt ttgctgaatc ggagtctgga aatatttatg tgtatttttt
      481 aatgaataaa aatttatttt aaaaacaata atttagaggt acagttaatt atatttttat
      541 gatactgtac ttctagtttt ttctattgta gatttattat ttactaataa atctacaata
      601 gaagtgcttt tgttgtaaga atcattttat ctaatgattg ttttttataa tagttaaatt
      661 tccatttgta gtgtttaaat ataaatctat aacagcattt ctataaatgt tataaatcac
      721 tataatgatt caactcaaag ttactgctta aagaagcaga gattttatca aggtatatca
      781 tggaaaaaaa tattttattg taatatttat aagattttat tatggaaata atgtaaaaac
      841 tttataaata atatatttta tacctagtta tagataaatt tatatagtta ttattaaaaa
      901 aagcaataaa aagtttaatt caatttagca aatttagtga tataattaaa aaagaaaaga
      961 aatatggact tatttggaat aattttgaca atctatttac tacacgtgta gagtcgtata
     1021 taattaaatt atacataaaa tataaaaaaa taatttagta atacgttagg agaaagtatt
     1081 atgataaagt caagcttatt ttggaatatt ttcattgcga tatcctttat gatagaatgg
     1141 tttctttgta agaaaatgct agattataca agtgagaaaa ggatttctaa caaaaaaata
     1201 aacttttgta tggtaggtat tattgttttt gctgacataa tatatttttt tgatgtacct
     1261 ccaaatataa gagtaattat atctatgata attactattg cattttataa aatctcatat
     1321 gatgtggggt ttataaagtc tgtattaata tccttaattt attggatgtt actaatcgcc
     1381 acagatgctt tgagtatatc tttaacagtt tggcttaatt ctataaatga catgagtagt
     1441 atggggacgg gagatatata cagaattgag tctataatat tgggaaagat acttttgatt
     1501 gtgtctttgc ttttatatag agccttaaag ataaaactta atatagaaat aaataaaagg
     1561 acattatttt atatagttat tcctatagtc gctaatatag catctttttt tgtaattttt
     1621 gaatacatat ttaatccagg gtctggtagc ttaatacata atttccaatt cgttatgatt
     1681 tctgttgtat tgcttatatc aagtatcact ttagttttaa ttgctaaaaa attacagcaa
     1741 tataatactt tagttgtaga aaacaatatg attaaaaata ctttgaagta tgaaaatgag
     1801 tattatgaag atatagaaaa gaaatattta aaaactagat tactaagtca tgatatgaaa
     1861 aatcacatat tgtgtataaa tgctatgatt aaaaaaggta ttgatgttac ttcttattta
     1921 aataatttgc aggtagaaat tcagagtaat gacttgttat ttaatactgg taattttata
     1981 ttagatgcta tattaagtga aaagaaagag gtttgtgata agaatgatat agaactaaaa
     2041 ataggaataa attttagttg ttgtgaagct gttgaattag tggatatatg tcatatattt
     2101 tcaaatattt tagacaatgc aattgaggca tgtaataaaa ttgatagtgg aaatagagtt
     2161 atttgtgtta aaggtgatgt tatgcaaaat ttttatttaa taagagttga aaatactaag
     2221 atgaataaga ttattactaa aaatggagat attttgacag acaaaaaagg ttctcttcat
     2281 ggacttggaa taaaaagtgt aaaaaactct gtaaataagt atggtggtaa tgttgtaatt
     2341 gaatatgatg ataaaaaatt tgtagttaaa attgctattc cacttagaaa tgtgaagaaa
     2401 gcagttaatc atgtgattta aatgtatata aatttgatgt gtagaaattt aatatataag
     2461 aattaatgta taaaagtgat gcatagaagt ttaatatata agaattaatg tataaaagtg
     2521 atgtat
//
LOCUS       DAEQCW010000219         2507 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.220, whole genome shotgun sequence.
ACCESSION   DAEQCW010000219 DAEQCW010000000
VERSION     DAEQCW010000219.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2507)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.220"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..1701
                     /locus_tag="KRO40_003580"
     CDS             <1..1701
                     /locus_tag="KRO40_003580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094372.1"
                     /translation="LLIYNIFYILVSNRIKDFGIFRALGFNPNDIFKIMILEVSIYSI
                     ISISIGLILGGIIASLSREYVIGVIYNVNYINSIKNQNYINTYIISILLSLGTIIISV
                     SKPLMLSVKTDPMICIRRNNEKVDIKQNSFINKFMIKLFKDYGNIASKNIQRNKKRTN
                     LSIASMVIIFFLMATIYTKSTSNFLSDGVLKYWIQGDYLLHNIDISTIRSNNKGYDKN
                     VLQEIKAIDGVTKVNSYRHKWFNIKIDDKSINKNSDYWKKNKDNIEARSEVKDGIKVY
                     NNSFEFLGIEDTDILEDFLINGKENIDKFSKQPYLYITKKSSDSLNIKKGDRIKVYFD
                     IIDSKTNNFTKTISQEFIVCGIITTLPVTSQVGAEFGGVISTNQFNKFTGISSYERFD
                     IWTSKLANDKYVESELNKITEKTNKGILIPYKAETAEYEKIDNQKTLIMVLVTGIIVI
                     LSLFNCCNTIVTSINSRSREFALFRGIGISKHEINKIVKLESYIYIIVSFCISIIPIL
                     IVRSIIIKPFESINLINWKFIGAIILIVFILVSIIMITTLKTLNKIQNENFMEEIKTL
                     "
     gene            2032..2376
                     /locus_tag="KRO40_003581"
     CDS             2032..2376
                     /locus_tag="KRO40_003581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094373.1"
                     /translation="MYCLSVVLAIYGIYVFINCTEYIYTMLSTKHLTVKGNEYTIINY
                     YMSNFSQYIIFAILLASMGFVIQKIVHMHFSEIELSGNYSTTVRNISDISLDNDNEMF
                     NRGNIENSILKK"
BASE COUNT         1087 a          221 c          342 g          857 t
ORIGIN      
        1 ttattaattt ataatatttt ttatatatta gtatcaaata gaataaagga ttttgggata
       61 tttagggctt tagggtttaa tccaaatgat atttttaaaa taatgatttt agaagtatct
      121 atatactcta ttataagtat ttctataggt ctaattttag gtgggataat agctagttta
      181 tcaagggagt atgttatagg agtaatatac aatgtcaact atataaattc tataaaaaac
      241 cagaactata taaacacata cataatttct atattattaa gtttaggaac tataataata
      301 tcagtttcaa aacctcttat gttatcagtt aaaactgatc caatgatttg tataagaaga
      361 aataatgaaa aagtggatat aaaacaaaat tcctttataa ataaatttat gataaaactt
      421 ttcaaagact atggtaacat agcatcaaaa aatatacaaa gaaataagaa acgtacaaat
      481 ttatctatag catcaatggt aattatattt ttcttaatgg caacaatata cacaaagtct
      541 actagtaact ttttaagtga tggtgtatta aaatattgga tacaaggaga ttatttatta
      601 cataatattg atataagtac tatacgttca aataataaag gttatgataa aaatgtacta
      661 caagagataa aggcaattga tggtgtaaca aaagtaaact catataggca taagtggttt
      721 aatataaaaa ttgatgataa aagtataaat aagaactctg attattggaa aaaaaataaa
      781 gataatattg aagctagatc agaagtaaaa gatggaatca aggtatataa taattctttt
      841 gaatttttag gaatagaaga tacagatata ctagaggatt tcttgataaa tggaaaggaa
      901 aatatagata aatttagtaa acaaccatat ctgtatataa caaagaaatc cagtgattcg
      961 cttaatataa aaaaaggaga tagaataaaa gtatactttg atattataga ttcaaaaaca
     1021 aataatttta ccaaaacaat atctcaagaa tttatagtat gtggaattat aactacatta
     1081 ccagtaacct cacaagtggg agctgaattt ggcggagtaa tatcaacaaa tcaatttaat
     1141 aagtttacag gaatatcatc ttatgaaaga tttgacatat ggacgagtaa actagccaat
     1201 gataaatatg ttgaaagtga gttaaacaaa ataacagaaa aaacaaataa aggaatttta
     1261 attccataca aagctgaaac agctgaatat gaaaaaattg ataatcaaaa aacactaatt
     1321 atggtattag taactggaat tatagttata ttatctttat ttaactgttg caatactata
     1381 gttactagta ttaatagcag aagtagggaa tttgcactat ttagaggaat aggaatatca
     1441 aaacatgaaa taaataaaat tgttaaattg gaaagttata tatatattat agtaagcttt
     1501 tgtatatcta taatacctat tttaattgta agaagtataa taataaaacc ttttgaaagt
     1561 atcaatttaa taaattggaa atttataggg gctattatcc taatagtatt tattttagta
     1621 tctataatca tgataactac actaaaaaca ttgaataaaa ttcaaaatga aaattttatg
     1681 gaagaaataa agactttata gtgaacagcc tataaattaa agaggtttta tatgaaatta
     1741 attgcaatta tcgataatgg tgtagatatt gattttaaat aatttagaaa taaaaataaa
     1801 ataagttatc caagttatat gtatggtgta ataggggtac aatgtatagc aaatataaat
     1861 attggcttaa taaaactcta ctcttaagtc tactgtcgtt ttaacacaag actaataata
     1921 agtgtaacct aaaaattatt gataatacaa taaccttgtt tatgataaat aacaaatatt
     1981 aagtgttgta aagatagtaa gtttaaaaaa atatcaaaga tttcaatcac aatgtattgt
     2041 ttatctgtag tgttagctat ttatggtata tatgtattta taaattgtac tgaatatata
     2101 tatactatgc tatctacaaa acatttaaca gtcaaaggaa atgaatatac cattataaat
     2161 tattatatga gtaactttag tcagtatata atatttgcta ttttacttgc atcaatggga
     2221 tttgtaatac aaaagatagt gcatatgcat ttcagtgaga tagaacttag tggtaactat
     2281 tcaacaactg ttagaaatat aagtgatatc tctttagata atgataatga aatgtttaat
     2341 agaggcaata ttgaaaatag tattttaaaa aaataaataa tataaatata taaaatgtga
     2401 ttgaataaag cttagaatac ttagtgtatt ttaagctttt tttattatta agatttcaaa
     2461 gtattaaatt aactatataa aatcatataa aaataatttt aaaatat
//
LOCUS       DAEQCW010000220         2506 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.221, whole genome shotgun sequence.
ACCESSION   DAEQCW010000220 DAEQCW010000000
VERSION     DAEQCW010000220.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2506)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.221"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            330..1856
                     /locus_tag="KRO40_003582"
     CDS             330..1856
                     /locus_tag="KRO40_003582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH2094374.1"
                     /translation="MNESYWFLNSSPKEYNKLGENIKTDCLIVGGGITGLTTAYLLAK
                     EGKKVVLVEADKIGYGTSGRNTGKVTCQHDIFYSKIEKKYGLDKAKSYYNANNEALNL
                     VEQIIEENNIKCDFKRETSFVFTEKEDTIKDIKDEYRTCKKIGINCEYHETIENIPLD
                     IKGAISFTNQGQFNPKKYIDGLAKAAVNLGLKIYENTPVVDLEKGKICRVKTREDNII
                     EAENVIISSHSPWYDGLNFYFAKEYAERAYLMVAVLENKLADGMFISIDDPSITFRQY
                     NDGSENLLIFGGGDHKVGQGGTEKEIFDDLEHYGKEVFKVKDFKGKWSAQDNMSFDNV
                     PYIGYINKREDNIYVATGFSKWGITNGTAAGIIIKDLIINNNSDYKDTFNPSRLGSYF
                     SKDFIKENANVAINYVSGKLKIGSGDMPKNNGEGKIVNIDGKRYGVYKDDNGDFYIVD
                     TTCTHLGCELNFNSEEKTWDCPCHGSRFDYKGNILEGPALKPLKLYGHGDNDVNPKLL
                     "
     gene            1884..2441
                     /locus_tag="KRO40_003583"
     CDS             1884..2441
                     /locus_tag="KRO40_003583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094375.1"
                     /translation="MNKLLKPITILLYIVYILSAVFFVANKEYGSLGLVAISLVGTFI
                     LSFINKQTERLLSKELYIMLALFIMFSSLLGTCFNFYDINYYDDFLHLWSGIISCIVA
                     FSIIKYFYTQREISKMSKVFLVIFLFMFSMGVASLWEIGEFLMDTFVGTTTQAGGLED
                     TMIDMVDALIGTIITIPFIVKKSNI"
BASE COUNT          986 a          211 c          451 g          858 t
ORIGIN      
        1 atataaaata tattgtaata ttaaaaaaat aatagtaaac tgattgcata aaaatgattt
       61 ttatataaaa tttaagcaga agaataaatt tctaacgaaa ttggatattt cttctgtaaa
      121 tacatattca aaaaaagaat tataagagtt tagtcagcag tcgtgtaagt aataaggact
      181 ttataaatat atagaaatat aatgatatta atataaccaa gcgattttta atttagcttt
      241 ttaataagct tattttttat actatttata ataaataaac tccatgatgg gaaaactatt
      301 actatttaat atgtaaagga gtattttaaa tgaatgaatc atattggttt ttaaactcaa
      361 gtccaaaaga atataacaaa ttaggtgaaa atataaaaac agattgtctt atagtaggtg
      421 gtggaataac gggattgaca actgcatatt tattagcaaa agaaggtaaa aaagtagtgc
      481 ttgttgaggc tgataaaata ggatatggaa cttctggaag gaatactggt aaggtaactt
      541 gtcagcatga tatattttac tctaagatag agaaaaaata tggattagat aaagcaaaat
      601 catattataa tgcaaataat gaagctttaa atttagttga acaaataata gaagaaaaca
      661 atataaaatg tgattttaaa agggaaactt cttttgtatt tacagaaaaa gaggatacta
      721 taaaggatat taaagatgaa tatcgtacat gtaaaaaaat aggaataaat tgtgagtatc
      781 atgaaactat agaaaatatt ccattagata taaagggggc tattagtttt actaatcaag
      841 gtcaatttaa cccaaagaag tatattgatg gattggcaaa agcagcagta aatttagggc
      901 taaaaatata tgaaaataca ccagtagtag accttgaaaa aggaaaaata tgtagggtta
      961 aaacaagaga ggataatata atagaagctg agaatgttat aatttcatct catagtccat
     1021 ggtatgatgg attgaatttt tattttgcaa aagaatatgc agagcgtgct tatttaatgg
     1081 ttgcagtttt ggaaaataaa ttagcagatg gtatgtttat aagtatagat gacccatcaa
     1141 taacttttag acaatataat gatggaagtg aaaatttact gatttttgga ggaggagacc
     1201 ataaagttgg tcagggagga actgagaaag aaatatttga tgatttagag cattatggta
     1261 aagaagtctt taaggtaaaa gattttaagg ggaaatggtc tgctcaagat aatatgagtt
     1321 ttgacaatgt tccttatatt ggttatatca acaaaagaga agacaatatt tatgtagcta
     1381 cagggttctc taaatgggga attactaatg gaactgctgc tggaataata ataaaagatt
     1441 taataataaa taataattct gattataaag atacttttaa tccatccaga ctaggtagct
     1501 acttttcaaa agattttata aaggaaaatg caaacgtagc aataaattat gtaagtggaa
     1561 aattaaaaat aggtagtgga gatatgccta aaaataatgg agaaggaaag attgttaata
     1621 ttgatggaaa aagatatggt gtatataagg atgataatgg agatttttat attgtagaca
     1681 ctacatgtac tcatttagga tgtgaactta attttaacag tgaagaaaaa acatgggact
     1741 gtccatgtca tggttctaga tttgactata agggaaatat acttgaagga ccagctctta
     1801 agccattaaa actttatgga catggtgata atgatgttaa tcctaagtta ttataaaatt
     1861 atttttagga aggtaaagtg tatatgaata aacttttaaa gccaataact atactattgt
     1921 atatagttta tattttatct gccgtatttt ttgtagcaaa caaagaatat ggaagtctag
     1981 gtctagtagc aattagttta gttggtactt tcattttgag ttttataaat aagcaaactg
     2041 aaagattatt gagtaaagaa ttatatataa tgcttgcttt atttataatg ttttcatcat
     2101 tgttaggtac ttgttttaat ttttatgata taaattatta tgatgatttt ttgcatttat
     2161 ggtcaggtat aatatcttgt attgtggctt tttctataat taaatacttt tatacacaaa
     2221 gagagataag taaaatgagt aaagtgtttt tagttatatt tttatttatg tttagtatgg
     2281 gagtagcgag tttatgggaa ataggtgaat ttttaatgga tacttttgtt gggactacta
     2341 cacaggccgg agggttagaa gatactatga ttgatatggt agatgcttta ataggcacaa
     2401 ttataactat tccttttata gtaaaaaaat ctaatatata gttttaaatt ttttatatta
     2461 attataatgg atttaattaa tcatgttgag tttcaaggtc tatatg
//
LOCUS       DAEQCW010000221         2449 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.222, whole genome shotgun sequence.
ACCESSION   DAEQCW010000221 DAEQCW010000000
VERSION     DAEQCW010000221.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2449)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2449)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.222"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            341..1642
                     /locus_tag="KRO40_003584"
     CDS             341..1642
                     /locus_tag="KRO40_003584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBH2094376.1"
                     /translation="MGKSKDVEIEKSILGTILLDNKLSYKLDELNENMFMNDICLEIF
                     KIMKELKKENIVIDVATVKSKIDRKSLAIKTSDVTNLITWGQNFGLDGHIKILKENLA
                     RRSINQNCQNLLHSLNLGENIDTCIYKFESNIKEILDKDTYENDDVNSIAGKVLDFLE
                     NKKDIGFKFGIKLLDTTIGGLFKGELTTIAAKSGVGKTALALQIMLNSFKQGKKTLFI
                     SREMTSEQVFMRNICRVTGVSTRNMKSKEIDENDWKLIVNAIGDLSENNLIYINDKID
                     TISAIRKRIRQVKPDLLIVDYVQLLTSQKSMDKREREVATFSRELKNMTLDFNIPVIQ
                     LSQLNDEMKDSRPYGDRPMRDSKAIYHDSNNVVYIHQLKGSDYEEAVRDIGESEEAVR
                     ASEYRGIKMVDLIVAKCRDGQTRHKHFCYFGDKLHFQELNY"
     gene            1718..1993
                     /locus_tag="KRO40_003585"
     CDS             1718..1993
                     /locus_tag="KRO40_003585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBH2094377.1"
                     /translation="MLELRKIIELLEEHKIEVSIPKELHKYSLLEYLELCQQSGGTYF
                     YIKTLEGALKEARNELMIKLFNGKNYMELARMFEMSVINVRHIVRKK"
BASE COUNT         1012 a          197 c          474 g          766 t
ORIGIN      
        1 taaataagat attaatatcg agtaatgaat tatattgaac gatatatcaa taattggcag
       61 taagttatat caaataagat attactatcg agtaatgaat tatattgaac aatatattaa
      121 taattggcag taagttatat caaataagat attgctatta tgtagtaaat tatataaaac
      181 aatgtatcag aataaatagt atattaataa tttgtagtat atcatgacga ataatacagt
      241 cataacaaat agtgagtcat aacaaataat gtatttataa ttgataatgt atttaaaaat
      301 caaaatataa aaacttataa ggaaagagag attaatttat atgggtaaat caaaagatgt
      361 tgaaatagag aagtctattt taggcacaat tcttttagac aataaattaa gctataagct
      421 agatgaatta aatgaaaaca tgtttatgaa tgatatatgt cttgagatat ttaaaattat
      481 gaaagaactt aaaaaagaaa acatagtgat tgatgtggcc actgtgaaat caaagataga
      541 tagaaaatct ctagcaataa aaacgagtga tgtgactaat ctaattactt ggggtcagaa
      601 ttttggtctt gatggtcata ttaaaatttt aaaagaaaat ttagctagaa gaagcataaa
      661 tcaaaactgc caaaaccttt tacacagcct aaaccttgga gaaaatatcg atacttgtat
      721 ttacaaattt gaaagtaata taaaggagat tttggacaag gatacttatg aaaatgatga
      781 tgtaaatagt atagcaggga aggtgcttga ttttttagaa aacaaaaaag atattggatt
      841 taaatttggt ataaaattac ttgataccac tataggaggt ctttttaaag gagagctaac
      901 cacaatagca gctaaatcgg gggttgggaa gactgctttg gcacttcaaa taatgttaaa
      961 ttcatttaag caaggtaaaa aaactttatt tataagtaga gaaatgacca gtgagcaagt
     1021 atttatgaga aatatatgca gagtaactgg tgtaagtaca aggaatatga aatctaaaga
     1081 aatagatgaa aatgattgga aacttattgt aaatgctata ggtgatttaa gcgaaaataa
     1141 cttaatttat atcaatgata agatagatac aattagtgca attagaaaga ggataaggca
     1201 ggtaaagcca gatttattaa tagtggatta tgtgcaactc cttacatctc agaaaagcat
     1261 ggataagaga gaaagggaag tagctacttt ttcgagagaa cttaaaaata tgactttaga
     1321 ttttaatata cctgtaatcc aattaagtca gttaaatgat gaaatgaaag attcaagacc
     1381 ttatggagat agacctatga gggatagcaa agccatctac cacgatagca acaatgtggt
     1441 ttatatacat caattaaagg ggagtgatta tgaagaagca gtgagagata ttggagaaag
     1501 tgaggaggca gttagagcat cagaatacag gggaattaag atggttgatt taatagttgc
     1561 gaagtgtaga gatggacaga ctaggcataa gcatttttgt tactttgggg ataagttaca
     1621 ttttcaagaa ctaaattatt aggtcaataa agtagtaata acaagcttat taaaagtcgg
     1681 gaaatagcaa atagattata aaatatgagg tgaaaatatg ttggaattaa gaaaaattat
     1741 agaattactt gaagaacaca agatagaagt aagtattcca aaggagttac ataagtatag
     1801 tttattggaa taccttgaat tgtgtcaaca aagtggggga acatattttt atattaaaac
     1861 actggaaggg gctttaaaag aggctagaaa tgagcttatg attaaattgt ttaatgggaa
     1921 aaattatatg gaattagcga ggatgtttga aatgagtgtt attaatgtca ggcatattgt
     1981 tagaaaaaaa tagatatttt tggagaatac aagtgtgata tacttctgaa atagaagtta
     2041 ttatagttga aataaaattg tggttaataa attaaagttg tgtataagtt taagattata
     2101 gaggagtata agtgtgatta acaacatgat tttgtgaata aaattgagga tatatatgag
     2161 ttaaatgtgt gattaataag gtaaggttgt gtataagatt atgagtattt aaaaggaggg
     2221 gctataatta atagtgtaga gttgtgtgtt tgcttaagat tatataataa tttaatagat
     2281 taaactatac taataaggta aaatcgtgtg tttagttaaa gcttattata aaatcttgat
     2341 atgtgattaa tgatgcaata tgtgaataaa gttaagatta taatagattt aacctgtggc
     2401 taatagaata aaattgtgaa taaagttaag attataatag gtttaacct
//
LOCUS       DAEQCW010000222         2370 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.223, whole genome shotgun sequence.
ACCESSION   DAEQCW010000222 DAEQCW010000000
VERSION     DAEQCW010000222.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2370)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.223"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            940..2295
                     /locus_tag="KRO40_003586"
     CDS             940..2295
                     /locus_tag="KRO40_003586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBH2094378.1"
                     /translation="MSSTVKKKGKFPMGFYICSTTFSFERAAYYASKYLIYIFLTTAI
                     VHGGLGIDKGQAAIMQANLVAFTYLAPIIGGYISDRWIGARYTIPIGMLIMGVGYYLG
                     SIATTVSMVNAMIILVSIGTAFFKGNVSAVNGQLFDSQEELDTAFSVQYSFVNIGSFI
                     GTIAVGILYLKTFAKNGVLGFSQCFFIAAVLCVIGAIWFIYGWRFLGNAGKRPFKEGV
                     VAEKIEEKDKSPLTSMDKKRIWAIILISFFSVIFWVFWYLTYLAVYDYGAAFVNMNVG
                     GFDVPLAWFDSLNSLVCIVLGPVLGALWFKLASRPQGDMSLFKKTGLGLIFLGLAFLM
                     LVGAEFSRGVGAPETAKASILWIIMFGILLSLGEMLFSPLGNSFVSKYAPKKLLGVLM
                     GVWTFATFIAGKGYGYIYAFTLKFDMIKVYTIIPVILFVAAILLFLSDKTLSRLVEDD
                     K"
BASE COUNT          835 a          258 c          404 g          873 t
ORIGIN      
        1 tactgcatac aaaaatatat ttgagcaaat aagtaaagta ataaaaaaat caagatttca
       61 tatctaaaaa ctattctgaa cattaattta atttatattt tcataggaaa tattttatat
      121 aatataattg ataaatataa tttgaatttt tctaattatt tactgtcgat taatagattt
      181 ttttcttgca tataagtgca tatttatggt acgatttaca tggtgaaata aaaaagggga
      241 ggtgaaaaat aaatattcgt gaaaaagttt tcagtttgag gtattttatg aataatatat
      301 tttgaggtat tttataaata atatattata cataaagagt atagcctcaa taaatagtat
      361 caaagcgaat atatgggtaa ttactttaaa ataacagttt ttatgtttag attcacagtg
      421 tttattataa actaatgtgt aagaaataag cctaatctgt gaatagatag tagtttagtt
      481 atttaagttg agaattggtt gggtgaagta atatataaat ttaaaaaata aataaaaaca
      541 ttatttgaac aaaatatatg ttgctttatt cgagactcct ttaaaaaagc actaaaatgt
      601 aattacataa gttgctacaa aagggggatt ttagtttgta aaatactatc acgtaaaaaa
      661 taagaattgc atatggcgaa ggttttttca tggtattaga tgagaatata ttaatttata
      721 actatatctg aaaatagtga atttatataa tttaaattta tgattaagaa gtgtattaat
      781 tttattccat gagaatatgt actctacaaa taaatgcgca attatcttaa taataattac
      841 aaattgtttt acaaaataat aatattatat ctttcataaa agaaagaatt tggacaaaac
      901 gtaaaaaata aaaatacaat taagaaagga tttaaaatta tgagctcaac agtaaaaaag
      961 aagggtaaat ttcctatggg attttatatc tgctcaacaa ctttctcatt tgaaagagca
     1021 gcatattatg cttcaaagta cttaatatat atattcctta caacagctat agttcatggt
     1081 ggtcttggaa tagataaagg acaagctgct ataatgcaag ccaaccttgt tgcattcaca
     1141 taccttgcac ctataattgg ggggtatata tcagatagat ggataggagc tagatatact
     1201 atacctatag gtatgcttat catgggggta ggatactatc ttggttctat tgcaactaca
     1261 gtttctatgg taaatgcaat gataatctta gtttcaattg gtactgcatt ctttaaaggt
     1321 aacgtatctg cggtaaatgg acagcttttt gatagtcaag aagaacttga tacagcattt
     1381 tcagtacaat attcttttgt taatataggt tcttttattg gtactatagc agttggtatt
     1441 ctttacctta aaacatttgc aaaaaatggt gtacttggat tttctcaatg tttctttata
     1501 gcagctgtac tttgtgtaat aggtgcaata tggttcatat atggatggag attccttggg
     1561 aatgcaggaa agagaccttt taaagaaggt gtagttgctg aaaaaattga agaaaaagat
     1621 aagtctcctc ttacaagcat ggataagaag agaatttggg ctattatact tatatcattc
     1681 ttctctgtaa ttttctgggt attctggtat ctaacttatc ttgcagttta tgattatggt
     1741 gcagcatttg taaacatgaa tgttggagga tttgatgttc ctcttgcttg gtttgactca
     1801 ttaaattcac ttgtatgtat agtattagga ccagttcttg gagcattatg gtttaaactt
     1861 gctagtagac cacaaggaga tatgagttta tttaaaaaga caggtcttgg attaatattc
     1921 ttaggtcttg cattcttaat gcttgttggt gcagaatttt caagaggagt tggagctcct
     1981 gaaactgcta aagctagtat actatggata atcatgtttg gtattctttt aagtcttggt
     2041 gaaatgttat tctcaccact tggtaactct tttgtaagta agtatgcacc taagaagctt
     2101 ctaggtgttc ttatgggagt atggacattt gctactttta tagctggtaa aggatatgga
     2161 tatatatatg catttactct taaatttgat atgattaaag tatatactat aattccagta
     2221 atactatttg ttgcagcgat attattattc ttatctgata agacattaag tagacttgtt
     2281 gaggacgata aataatcagt aagcaattat tatgttttat aggttaatct actgtaatta
     2341 tgttgtatta gattgattta taactaatta
//
LOCUS       DAEQCW010000223         2361 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.224, whole genome shotgun sequence.
ACCESSION   DAEQCW010000223 DAEQCW010000000
VERSION     DAEQCW010000223.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2361)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.224"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(91..1383)
                     /gene="brnQ"
                     /locus_tag="KRO40_003587"
     CDS             complement(91..1383)
                     /gene="brnQ"
                     /locus_tag="KRO40_003587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBH2094379.1"
                     /translation="MGEKQINFKDVIVIGFALFAMFFGAGNLIFPPYLGVLSGSSWLV
                     AFIGFLFADGGLALLAVIAATKFNGDTSKMFSRAGKGLSIALGCAMVICIGPLLAIPR
                     TAATTYEMGILPTIGSGISPVIFSIVFFALVLVLTIRPSKVVDIVGSILTPALLIALA
                     VLIVKGIVSPLGEIRDSSLIQNVFAEGITQGYQTMDALAASVFASIIIMSVIAKGYTG
                     EKEKMKATISAGVIAVIGMALVYGGLCYLGATVSQQYGQDVQQTALIVAITAALLGTT
                     GKILLAIIVALACLTTAIGLSSAAGQYFSTLTDGKLKYEHIVIVVCVFSAIISNFGVS
                     TIIQFSSPILSMVYPATITLVILALFSNKIKNDNVFKCAAYMALLVSVLTVATSFGIK
                     IPLVNSLPFASLGFNWIVPVVIAGIIGNFIPSKSSKTA"
BASE COUNT          792 a          380 c          249 g          940 t
ORIGIN      
        1 ctacaataat ttaataattc ttttaaatat aaaaaggaat tgcctatata atttaaaggc
       61 aattccataa ttatcaatta gtttttatta ttatgcagtt ttactgcttt tagatggaat
      121 aaagtttcct attattcctg ctattacaac tggaactatc cagttaaatc ctaatgaagc
      181 aaatggtaag ctattaacta gaggaatttt tataccaaaa cttgttgcaa ctgttaatac
      241 acttactaat aatgccatgt atgcagcaca tttgaacacg ttgtcatttt taattttatt
      301 actaaataat gctagtataa ctagagttat agttgctgga tataccatac ttagtatagg
      361 agaagagaat tgtattattg tacttactcc aaagtttgat atgattgcac taaatacaca
      421 aactactata actatatgct catactttaa ttttccatct gtaagtgttg agaaatattg
      481 accagctgct gaagaaagac ctatagctgt tgttaaacat gctaatgcaa ctataatagc
      541 caataaaatt ttacctgtag ttccaagtaa agctgctgtt attgcaacta ttaaagctgt
      601 ttgttgaaca tcttgtccat attgttgaga cacagttgct ccaagataac ataatccacc
      661 ataaactaat gccattccta ttactgcaat tacacctgca cttattgtgg ctttcatctt
      721 ttctttctca cctgtataac ctttagctat tactgacatg attataattg atgcaaatac
      781 actagctgcc aatgcatcca ttgtttgata accttgagtt ataccttctg caaatacatt
      841 ttgtattaaa gaactgtctc ttatttctcc taatggagat acgatacctt taactattaa
      901 tactgctaaa gctataagta aagctggagt taatattgac ccaactatat ctacaacttt
      961 tgatggtctt attgttaaaa ccaatactag agcaaagaat actatagaga atattactgg
     1021 gcttattcca gaacctattg taggtaatat acccatttca taagttgttg ctgctgttct
     1081 aggtattgct aaaagtggcc ctatacagat taccattgca catcctaatg caatacttaa
     1141 tcctttgcct gctcttgaga acatcttcga tgtgtctcca ttgaacttag ttgctgctat
     1201 aactgctaat aatgccaaac caccatctgc aaaaaggaat cctatgaaag ctactagcca
     1261 actacttcca gataaaactc ctagatatgg agggaagatt aagttccctg caccaaaaaa
     1321 cattgcaaat agtgcaaatc caattacaat tacatcttta aaattgattt gtttctcacc
     1381 catttaaagc acccccattt gaattttact accttttact aaaaaataag tccaatctct
     1441 taattaaatg aaaacctttt gacgagattt tatttaatta tacatttttg acttaaattt
     1501 gtcaattatg tttcataatt tataaaatct tcacaatatt taatacaact ttcttaatta
     1561 aacaaaatca acctgtatac tttaaacata gttggttttt tgttttttct ctaatttttc
     1621 ttgataaaat taactattcc gaataattaa aatattaaga ttttttagat tattcgattt
     1681 attattaagt tgtattgctt tatatactgt atatatcact ctcctttttt acattcatat
     1741 aatcttttta attcaattta aattttaaat attttgtgtt tattatataa tctgaaaaaa
     1801 aagcagtcaa tagcattttt aattttttta attttcaaaa ttatgattct caaaaaatcg
     1861 ttttcctttt atcataacac ctatttacgt taattcttgt agtattttgt atttattttg
     1921 ctaaattgac agttaacttt attcaatttt tattctactt gcgtagattt acctcttgtt
     1981 ttttactctt aaaaccattt tttctgaaaa ttccttatta tgatttatca acttattttt
     2041 cttcataaca attactctct aacttccaac ttacttaaac tttgcagttg ctagtattca
     2101 cgtttacata cttatatgtc ataattaact aaaaattctt aatatatctc tcaatgaaaa
     2161 caatttactc atttatttaa tacatttata taatcatatg tcttaaattt tgttttatta
     2221 ttttattatt gtcacaattt tatttatatt atatttttgt aaaaatcatt taatatgtat
     2281 acttaaattt ataaaattac tctaaaattc ttttttaatc tctattattg ttaaaaaata
     2341 aactatatat ttttttgata t
//
LOCUS       DAEQCW010000224         2342 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.225, whole genome shotgun sequence.
ACCESSION   DAEQCW010000224 DAEQCW010000000
VERSION     DAEQCW010000224.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2342)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.225"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(120..2213)
                     /locus_tag="KRO40_003588"
     CDS             complement(120..2213)
                     /locus_tag="KRO40_003588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBH2094380.1"
                     /translation="MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPE
                     GKVCWQVLYPEKNSTCSFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQD
                     GTVVHMHQSIDIANSTSLNKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDAL
                     IRGTDEYIYICNMKTGVFRYSPSQVELFDLPGEIVENPLVYWKKIVHPEDWNRFYKSN
                     TEIGKNQMDYHTVEFRAKNRSGEYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKID
                     SLTQLLNYHEFMSVFEDKISNPMIEKLCIVLLNIDDFKNVNEMYDRDFGDNIIKTLAQ
                     SIQSILPDNAELYKLDGDEMGILVDNVEENEILTLYNQIQNMIIHLQLWRKYGLNITI
                     SAGCVIYPKHGDTVKELYKCASYSLQYAKEHGKNRLVFFSQEILKNKMYSLEMMRDLK
                     ASINDDFRGFSLRFQPQVDTESHKIIGVEVLLRWTNDKCKAISPLEFIPILEENDMIN
                     IVGAWVLRMALRTFRKWIDYYPFFKVSVNVSAVQILEDTFIEDIVKIIDDENFPYQNL
                     VLELTESHTVQNMSILQFKFKVLQDLGIYIAMDDFGTGYSSLEVLKFSPIDIVKIDRV
                     FVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVETQEEYDLVKQIKPDYIQGYLFGK
                     PQTATEIFDLLKLDN"
BASE COUNT          787 a          392 c          231 g          932 t
ORIGIN      
        1 aacatccatt gaaatgctat tttcttatat tacaatttat aattgatata tcttcaatat
       61 aattatttaa tgtatttttg attttaaagc ttttcagtga tattattgat aaattagaat
      121 taattatcta gctttaaaag gtcaaagatt tctgttgctg tctgcggttt tccaaataaa
      181 tatccttgta tgtaatctgg ctttatttgt ttaactaaat catactcttc ttgtgtttct
      241 acaccttcta aacatacttt tattcctacg tcatgacaaa ttgcaacaat aaaatgtata
      301 aatgtagcat caaacttact ctttaatata tctttaacaa atactctatc aattttcact
      361 atatctattg gagaaaattt taaaacttct agagacgagt atcccgtacc aaaatcatcc
      421 atagcaatat aaattcctaa atcttgtaaa accttaaatt taaactgtaa aatactcata
      481 ttttgtactg tatgactttc tgtcaattct aaaacaagat tttgataagg aaaattttca
      541 tcatctataa tttttactat atcttcaata aatgtgtctt ctaatatttg aacagctgaa
      601 acgtttacac tcactttaaa aaaaggatag taatcaatcc atttcctaaa agtacgtaat
      661 gccattcgaa gcacccaagc ccctacaata tttatcatat cattttcttc taatattgga
      721 ataaattcca aaggagaaat tgctttgcat ttgtcattag tccaccttaa aagaacttct
      781 acacctatta ttttatgact ttctgtatct acttgtggct ggaatcgaag actaaacccc
      841 ctaaaatcat cattaattga tgcctttaaa tcccgcatca tttctaatga atacatttta
      901 ttttttaata tttcttggga gaaaaaaaca agcctgtttt taccatgctc tttcgcatat
      961 tgtaaagagt aactagcaca cttataaagt tcttttactg tatctccatg ctttggatat
     1021 attacacaac cagcagaaat tgttatattt aatccatatt ttctccatag ttgaagatgt
     1081 ataatcatat tctgtatttg attatataga gttagaattt cattttcttc aacattatca
     1141 acaagaatac ccatttcgtc cccatcaagt ttataaagtt cagcattatc tggtaaaata
     1201 gattgtatag actgtgctag tgtttttatt atattatctc caaaatccct atcatacatc
     1261 tcattaacat ttttaaaatc gtcaatattt aataatacta tgcataattt ttcaatcata
     1321 ggatttgaaa ttttatcttc aaatacactc ataaattcat gataattcag taactgtgtc
     1381 aatgaatcaa tcttattttg tttacctaat tgcgtcatta ttcctgcaaa aatacttggt
     1441 tctccaaatt catcacgcat tagttgacct ctacatctta accatatata ttctccacta
     1501 cgatttttag ccctaaattc cactgtatga taatccatct ggtttttacc tatttcagtg
     1561 tttgacttat aaaaacgatt ccagtcttct ggatgtacaa tttttttcca gtaaacaagc
     1621 ggattttcaa caatttctcc tggtaagtca aataattcaa cttgtgatgg tgaatatcga
     1681 aatacgcctg ttttcatatt gcaaatgtat atatattcat ctgtacctct aatcaaagca
     1741 tcataaagca atgtagaatt ataatcaaaa ttgtctcttg aaaaattaaa aactcctttt
     1801 tcttctttat tatttgatat ttcatgaaat tcattaatct taattggttt atttaagctt
     1861 gttgagtttg caatatctat tgattgatgc atatgaacaa ctgtgccatc ttgccatgta
     1921 attaaactat cataattttc aaaaacacga tttaacttat tacatttttc ataccacttt
     1981 attaatactc cttttttatc attctttaat aattctaaaa ctttacaaaa actacaagta
     2041 gaattttttt caggatataa tacttgccaa caaacttttc cttctggatc taaaatatta
     2101 tattcttctt tcattttttt gttcataaaa ataatttcat tagtatgaat atttgtaaca
     2161 tatatattaa tctgtagttg atttaatata acttcaaaat tatgtttgtt catatactta
     2221 tctcctccat agttactgct ctttataaca acattgttaa aattattctt tttagaagat
     2281 ttacttataa cttatacata tacactaaat accttaattt aattagaaag tttattactt
     2341 ca
//
LOCUS       DAEQCW010000225         2314 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.226, whole genome shotgun sequence.
ACCESSION   DAEQCW010000225 DAEQCW010000000
VERSION     DAEQCW010000225.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2314)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.226"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            875..1537
                     /locus_tag="KRO40_003589"
     CDS             875..1537
                     /locus_tag="KRO40_003589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094381.1"
                     /translation="MSILEIKNLNKIYGKSETEVKALSQINLKINSGEFVVIVGKSGS
                     GKSTLLHIMAGLETPTNGDVIIDNINISSLDEKKRSALRKEKLGLIFQSYNLIPVLTV
                     EENIKLPTINIKNKDEAYINELMELLGIKDRRMYLPNQLSGGQQQRVAIARALVNKPS
                     IVFADEPTGNLDTKTESDVLSLLKESQKKYNQTIIMITHNIDITKYADRVIEIEDGFI
                     RE"
     gene            1546..>2314
                     /locus_tag="KRO40_003590"
     CDS             1546..>2314
                     /locus_tag="KRO40_003590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBH2094382.1"
                     /translation="MKLNYIVKKYIMGNKKNTLLIVVSIVISTALFLIMNIISEDATN
                     LMINQAKNEFTLKHAQYINPKDEEIKYIENNTSIDKVGKSMLLGISDIGKGQTLQILS
                     QDKVAEELNDIYTLEKGKLPVAENEIAIDSWYIKQKKIKNPIGKRITLDYRRQGIDQE
                     DLYTGEKEFKITGILNSNPILKAQGTSIGLISNDCAIKNIPTKNKYDQVMFTFKKEKN
                     IQRQSQKLIKNGNLNENNIYFNNELLIAISDSMNLKIP"
BASE COUNT         1046 a          202 c          361 g          705 t
ORIGIN      
        1 taattgaata aattaaaaat ataatgaaag tttagtttta attcatttat ttaataaaca
       61 tttcaagtaa aataatgttt aaatcagaaa tataaataaa tattattata atcgttatta
      121 aagaccaaaa atcccacctt agaagtttgt atcatatgaa acctttatag attatgaaag
      181 caataatata gtgtatgata tataaaataa gttataaaag tattttttta gatattcaaa
      241 aagacattgt aagttatatt aataatatgg gtatcaacga attttggata taatgagttt
      301 ttcaacttaa agttatgtaa taatgaatgt aaagaatatt taatgaaatc attttgttgg
      361 ttatgtctag ctgaatacaa taatctttta gataaagatt ttatatttga agataggtgt
      421 gaaaaaatta agaagatatt aacatcagca gtttagaggc aaagcatgta aagtaaagtc
      481 tgggtaacta aaagtagtaa tttagattgt aactattgtt ataaatatga aaatgaggaa
      541 acaggaaata taagttagga tgtagaaaat aggttactaa ataaaaagct taattatata
      601 atcaaagaaa taggtatata ctgtacaatt tcatggtgaa gaacttttcc taaataaaaa
      661 ggttggtaaa agagatataa gaaataaaat tcaattataa gatatggtat gataactaaa
      721 ggcactatat ggagtgaata ggcggaagaa ttttttgaaa attataaaaa tagtttctgt
      781 tgctacatat caataagtat agatagagat tgcaaaatcc atagcaaaaa tcgaatttat
      841 aagtgtaaat aacatgtaag acaaggagta aattatgagt attttagaga taaaaaacct
      901 aaataaaata tatggtaaat cggaaacaga ggtgaaagcg ttaagtcaaa taaatctaaa
      961 aataaatagt ggagaatttg ttgtgatagt aggtaaaagt ggaagtggta aaagtacttt
     1021 actacacata atggcaggac ttgaaactcc aacaaatggt gatgtgatta ttgataatat
     1081 aaatatatca tctcttgatg aaaagaaaag atctgcatta cgtaaagaaa agttgggatt
     1141 aatatttcaa tcatataatt tgattccagt tttaactgtt gaagaaaata taaaactacc
     1201 aactataaat ataaaaaata aagatgaagc ttatattaat gaattgatgg agttactagg
     1261 aataaaagat agaagaatgt atttgccaaa tcaattatca ggtgggcaac aacaaagagt
     1321 agcaatagca agggctcttg taaataaacc atcaattgta tttgctgatg aacctactgg
     1381 aaatttagac acaaagacag agtcagatgt attaagttta ttaaaagaat ctcaaaaaaa
     1441 atataatcag acaataataa tgataacaca taacatagat ataacaaaat atgctgatag
     1501 agttatagaa atagaagatg gatttataag agagtaggta gatttatgaa acttaattat
     1561 attgtaaaaa aatatataat gggaaataag aaaaatacat tattaatagt tgtaagtatt
     1621 gtaatttcaa cagcgttgtt tttaattatg aatataataa gtgaagatgc gacaaactta
     1681 atgataaatc aagctaaaaa tgaatttaca ttaaaacatg cacaatatat caatccaaaa
     1741 gacgaagaaa taaaatatat agaaaataac acaagtatag ataaagttgg aaaatcaatg
     1801 cttttaggaa ttagtgatat tggtaaaggt caaacactac aaattctatc tcaggataaa
     1861 gttgctgaag aactaaatga tatttacaca ctagaaaaag gtaaattacc agtagctgaa
     1921 aatgaaatcg ctatagattc atggtatatt aaacaaaaaa agataaaaaa ccctatagga
     1981 aaaaggataa cattagatta tagaagacaa gggatagatc aagaagattt atatactggg
     2041 gaaaaagaat ttaaaataac tggtatctta aatagtaatc ctattttaaa agctcaagga
     2101 acatcaattg gccttataag taacgattgt gctatcaaga atattcctac taaaaataaa
     2161 tatgatcaag ttatgtttac ttttaaaaag gaaaaaaata tacagagaca atcacaaaaa
     2221 cttattaaaa atggaaattt gaatgagaat aacatttatt ttaataatga attattaata
     2281 gctatatctg atagtatgaa tttaaaaata cctt
//
LOCUS       DAEQCW010000226         2287 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.227, whole genome shotgun sequence.
ACCESSION   DAEQCW010000226 DAEQCW010000000
VERSION     DAEQCW010000226.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2287)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.227"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            185..2257
                     /locus_tag="KRO40_003591"
     CDS             185..2257
                     /locus_tag="KRO40_003591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBH2094383.1"
                     /translation="MKKVFGVLQKVGKSLMLPVALLPAAGILLGVSNALAGDALLAHF
                     PALANPTFQLIISIMESSGQIIFNNLPLIFAVGVAVGLTEGEGVAALAAIVGFLILNT
                     SMGVMAGVTEDMVDNSMYANIVGIPTIQTGVFGGIIIGIVAAYLYKKFYKIELPQYLG
                     FFAGKRFVPIVTSLVAIAIGIILSFIWPPIQEGLLSFSKNVIEANQTLAAFMEGSLER
                     LLIPFGLHHVFHNPFWYQFGEYVNKAGELVMGDQKIFFAQLKDGVNFTAGTFMTGAFP
                     FMMFGLPAAALAMVHEAKPEKKKFVAGIMASAALTSFLTGITEPIEFAFLFVAPVLFA
                     IHCLFSGLSYAIMQLLGVKIGFTFSGGLIDFLLFGVLPNRTPWYLAILVGIGFAVLYY
                     SVFRFMIRKFNLKTPGREDESETNAEVIEMSKNELASEILIALGNKDNLKSLDACITR
                     LRLVVNDINKVDKEKLKSLGAAGVMVIGNNVQAIFGPKSDSIKSDIKDIIEGKTKVES
                     TVTKNVDKNKVKKNMEVANMENALVEKIDSLTNGEILDIEEVPDSVFSSKLMGDGFAI
                     KSSDGLIYSPVDGTIGVIFPTKHAIIIKSQKSGVEILIHLGIETVNLEGNGFEVFVNV
                     GDEVKAGEKLVKMDLEYIEKNGLSTISPVVFTNLEQNQKLSIKKGVTTAKEENRVSIL
                     RDDIEKIG"
BASE COUNT          835 a          253 c          447 g          752 t
ORIGIN      
        1 caggcaagac ttatgtttat aaaaaaatta taatagttta tttttaattc tgaaattagg
       61 ttaatatagg tttatttata ttaacataag tttaatttta gaactaagta tactaatgta
      121 actttttata aacttaagtc ttttttattt aaaaaaatat aaaataataa ggagagaaaa
      181 gtaaatgaaa aaagtatttg gtgttttaca aaaagtagga aaatctctaa tgctaccagt
      241 tgcattactt cctgcagcag gtatattact tggcgtgagt aatgctttag caggagacgc
      301 attgttggct cattttccag ctttggcgaa tcctacattt caacttataa taagtataat
      361 ggaaagttca ggtcaaatta tatttaataa cttaccactt atatttgcag ttggggtagc
      421 tgttggttta actgaaggag aaggtgttgc agcattggca gccatagtag gttttttaat
      481 tctcaataca tctatgggtg ttatggcagg tgttacagaa gatatggtag acaattctat
      541 gtatgcaaat attgttggaa taccaacaat tcaaacaggg gtatttggtg gtattattat
      601 agggatagtg gctgcttatc tttataaaaa gttttataaa attgaattac ctcagtatct
      661 aggttttttt gcaggtaaaa gatttgtacc aatcgttact tcattagttg ctatagcaat
      721 aggaattata ttgtctttta tttggcctcc aatacaagag ggattactta gtttctcaaa
      781 aaatgttata gaagcaaatc aaacactagc agcatttatg gaaggttctt tggaaagact
      841 attaatacca tttggtttgc atcatgtttt ccataatcca ttttggtatc aatttggaga
      901 atatgtaaat aaagctggtg agcttgtaat gggtgaccaa aagatattct ttgctcaact
      961 taaagatgga gtaaatttca cagcaggtac ttttatgaca ggtgcatttc catttatgat
     1021 gtttggtctt ccagcagcag ctcttgctat ggtgcatgaa gcaaagccag aaaagaaaaa
     1081 atttgtagca ggtataatgg catcagcagc attaacctct tttttaacag gaataaccga
     1141 gccaatagag tttgcgtttt tatttgttgc accagtatta tttgcaatac attgtttatt
     1201 ttcaggttta tcatacgcaa ttatgcaatt attaggagtt aaaattggat tcacattttc
     1261 aggaggatta atagatttct tattatttgg tgttcttcct aatagaactc catggtactt
     1321 ggctatcttg gtaggtattg gttttgcagt attatactat agtgtattta gatttatgat
     1381 aagaaagttt aatttaaaga caccaggaag agaagatgag tcagaaacta acgctgaagt
     1441 cattgaaatg tctaagaatg aattagcatc agagattttg attgctttag gaaataaaga
     1501 caatttaaag agcctagatg cgtgtataac aagacttaga ttggttgtaa atgatataaa
     1561 taaagtagat aaagaaaaat tgaaatcact tggagcagca ggtgttatgg ttattggcaa
     1621 caatgttcaa gctatatttg gaccaaaatc ggattcaata aagtctgata taaaagatat
     1681 aatagaggga aaaacaaagg ttgaaagtac tgttactaaa aatgttgata aaaataaagt
     1741 gaaaaaaaat atggaagttg caaatatgga aaatgcttta gtagaaaaga ttgattcatt
     1801 aacaaatgga gagatattag atatagaaga agtgccagat tctgtatttt caagtaaact
     1861 gatgggggat ggatttgcaa ttaaatctag tgatggattg atttattcac cagttgatgg
     1921 aactattgga gttatatttc caactaagca tgcaataata ataaaatccc aaaaaagtgg
     1981 agtagaaata cttatacatt tagggataga aactgtaaac ttagaaggaa atggatttga
     2041 agtatttgtg aatgtaggag atgaagtaaa agcgggagaa aaattagtta aaatggactt
     2101 agaatatatt gaaaaaaatg gtctatcaac aataagtcct gtagtattta cgaatttaga
     2161 acaaaatcag aaattaagca ttaaaaaagg agtaaccaca gcaaaagagg agaatagagt
     2221 aagtatatta agagatgata ttgaaaaaat aggatagcta tatgatagtg taactaaaag
     2281 ttatgtg
//
LOCUS       DAEQCW010000227         2282 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.228, whole genome shotgun sequence.
ACCESSION   DAEQCW010000227 DAEQCW010000000
VERSION     DAEQCW010000227.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2282)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.228"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..162)
                     /locus_tag="KRO40_003592"
     CDS             complement(<1..162)
                     /locus_tag="KRO40_003592"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2094384.1"
                     /translation="MLNINVFWIFLPIFSTTIEWIVLKFLLNEFSELRKNRLTLNSSI
                     VIAIMIITML"
     gene            complement(156..284)
                     /locus_tag="KRO40_003593"
     CDS             complement(156..284)
                     /locus_tag="KRO40_003593"
                     /inference="COORDINATES: protein motif:HMM:NF016296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094385.1"
                     /translation="MEYIQFICKNTVVINGKDIPVSKYRMANLKKKLTYVLGDVLC"
     gene            complement(423..1133)
                     /locus_tag="KRO40_003594"
     CDS             complement(423..1133)
                     /locus_tag="KRO40_003594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBH2094386.1"
                     /translation="MYRIVICEDDITQIAFLRECILKSLEGISSQIELFEFNSGEELL
                     ETNLEGIDIFFLDIKMLQLTGMDVAKIIRETNDTSEIIFITSIVDYIQEGYKVRAYRY
                     LLKPIDFGDLNESILSCISDIIKKRENFMLIENKGIINKILINSIMYIEVRKKVLTIH
                     TKNDTYYTKNSMDKIELELEKYNFFRCHKSYLINLEYIQFICKNTVVINDEDVPVSKY
                     RMADLKKKLTYVLGDVLC"
BASE COUNT          909 a          313 c          172 g          888 t
ORIGIN      
        1 caacatagta attatcataa tagcaattac tatgctacta tttagggtta atctattctt
       61 tcttaactca ctaaattcat ttaataaaaa ttttaataca atccattcta tcgtcgtaga
      121 aaatataggt aaaaaaatcc aaaatacatt tatatttaac ataatacatc tcccaataca
      181 tatgttaatt ttttctttaa attagccatt ctatatttac taactggtat atctttacca
      241 ttaataacta cagtattttt acatataaat tgaatatact ccaaattaat taaatagctc
      301 ttgtaacatt tttaaaaatt tattctttct taaatcactg aattcatttg ataaaaattt
      361 taatacaatt cattctatcg ccgtagaaaa tataggtaaa aaaatccaaa atacatttat
      421 atctaacata atacatctcc caatacatat gttaattttt tctttaaatc agccattcta
      481 tatttactaa ctggtacatc ttcatcatta ataaccacag tatttttaca tataaattga
      541 atatactcca aattaattaa atagctctta tgacatctaa aaaaattata tttttctagc
      601 tctaattcta ttttatccat actattttta gtataataag tatcattttt agtatgtata
      661 gtcaaaacct ttttcctaac ctctatatac ataatactat taattaaaat tttattgatt
      721 atacctttat tttctatcag cataaaattt tctctttttt ttataatatc cgatatacaa
      781 ctcaaaatac tttcatttaa atctccaaaa tctataggct ttaataaata tctataagcc
      841 cttaccttat agccttcctg tatgtaatca actattgaag ttataaatat tatttcagaa
      901 gtatcattag tttctctaat tattttagcc acatccatgc ctgttagttg aagcatttta
      961 atatctaaaa aaaatatatc aataccttct aaatttgttt ccaataattc ttctcctgaa
     1021 ttaaactcaa atagttcaat ttgactagaa ataccctcta aggactttaa tatacactct
     1081 cttaaaaaag ctatttgtgt aatatcatcc tcacagataa ctattctata cataaacacc
     1141 cctccttaga cattagatct gaaaacaaat aaaatatcaa tttataaata attatttagt
     1201 tatacaacta acatggtcat caaatactat tattcactta aaaaatcacc ccctattttt
     1261 agtatgttaa caacaaaata agaagatatc ttagattttt aaaaacaatt aatacttaat
     1321 gtagttttgt atactattta taggtaattt tttatatcat tttaaacatt aaaattattg
     1381 atgtttaaga actattatat tgatagtaat atataattaa tgatatcaaa aatttttaat
     1441 tagacttctc tcttattcaa gatttttcta tataaaatct aagaataaat agaaaactaa
     1501 catctaacct tttatttttt attttcgatc tatttacttg aattttaaca taaatctatc
     1561 ttttagtata tattaatcat gctgaatttg tgatgacatg tatacaaaat atcgtttagt
     1621 attttctaat aaaaaatatt actgaaatta aaaatctaca atagcattta acaagtaaaa
     1681 acatgtttac acaaatatat aatttaaggt ctttaaaata gagtatgtat tattctaaaa
     1741 attagttata gttatcacat aaaaatagaa aagaattttc aaaagattta aagaacatac
     1801 atacttcaat tgcagaagat gtaatgttaa gtgaactagc attcttcgag gaaaaataga
     1861 ctcaaaaaat tagaaaatag aatcaggttt tagatgattt aagtatttat tttcaaaaaa
     1921 gaaatttgat tctaagttaa taaagaaata tttaaaaaaa tcaaaaaatt ttcttaaata
     1981 agtaataggt tttgtaaaaa tggaaaaata tcaaaataag actatgattt ttaaaactat
     2041 agccttatca ataaattttt atttaaagaa cacacataaa tatttttaaa cctaatttat
     2101 gtgaagtttt atgtattttt tatataagta gtattctaat cttactcatc taatatacca
     2161 aaaagactgt aagtaagttc acttttatgc aaacttaccc acaatctctt ttacacatta
     2221 attctattta ttaaaattaa aaatatttac tgctattcta cccaataaag atgatactgt
     2281 tg
//
LOCUS       DAEQCW010000228         2099 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.229, whole genome shotgun sequence.
ACCESSION   DAEQCW010000228 DAEQCW010000000
VERSION     DAEQCW010000228.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2099)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.229"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            133..414
                     /locus_tag="KRO40_003595"
     CDS             133..414
                     /locus_tag="KRO40_003595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094387.1"
                     /translation="MASKQIPRNNLEKFLRIRVLSHTGDKIHIKLPVNFAKRMIENNA
                     LDLFNGKDDVVDGKKVTEILVKAFDYDLTGEVVHLERKNGDIIKVSIVQ"
     gene            678..932
                     /locus_tag="KRO40_003596"
     CDS             678..932
                     /locus_tag="KRO40_003596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094388.1"
                     /translation="MENKDFKLTICIFAFVIGVVVLFCCIGLGEFSAEHIIQQNGGIM
                     DTDQYNIYLDQSISQYRNFGSILALLGGIGILFDKYIRKY"
     gene            977..1300
                     /locus_tag="KRO40_003597"
     CDS             977..1300
                     /locus_tag="KRO40_003597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094389.1"
                     /translation="MATEIFTVKITPLEAQKMIKENLDADLVFSDSYNLGDDKFILIT
                     TFEKYYARNNSDAGLIVVYENTTGKTVIKATSTGSAIGILKIDWGAGGNLLKRVKNIL
                     ADYII"
     gene            complement(1859..2053)
                     /locus_tag="KRO40_003598"
     CDS             complement(1859..2053)
                     /locus_tag="KRO40_003598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HBH2094390.1"
                     /translation="MINYMVEIIYSEKISEVENMLKIENIQYEFTSRDGFIFFGFYDM
                     TDAYRFETLCSDEKIRFKRI"
BASE COUNT          884 a          172 c          295 g          748 t
ORIGIN      
        1 atattaaaga agaaggaata taaaacaaga ttagaaaata atagtgttac tttcataata
       61 aatacatata aagatatttt taagaataaa atttattatt aaataaaaaa taaaggagag
      121 tgatttaata gcatggcatc aaaacaaata ccaagaaaca atttagaaaa gtttttaaga
      181 ataagagtct tatcacatac aggcgataaa atacatataa agttacctgt aaattttgca
      241 aagagaatga ttgagaataa tgctttggat ttatttaatg gaaaagatga tgtagtagat
      301 ggtaaaaaag ttactgaaat attagttaag gcatttgact atgatttaac tggagaagta
      361 gttcacttgg agagaaaaaa tggagacatt attaaagttt caattgtaca atagaattat
      421 tttatatgaa ttttattttt gaatagttat aaataattag aaatttgtaa aaaagtataa
      481 tatattatta gtaatggtac agaatacaca tttataattt atagatgtgt attttttgtt
      541 taaaaaattt aaatatataa aactataaag gttacaattt tggaaataga tgtaaatata
      601 tgttgtattg tataataaga gtaatataaa atctagtaaa aataatcaaa taaatttagc
      661 ttatgagagg gataactatg gaaaataagg attttaaatt aacaatatgt atatttgctt
      721 ttgtaattgg agtagtagta ttattctgtt gtataggttt aggtgaattt agtgcagagc
      781 atattattca acaaaatggt ggaatcatgg atactgacca atataatatt tatctagacc
      841 aatctatttc tcaatataga aattttggtt ctatattagc tctgttagga ggaataggga
      901 tattgtttga taaatatatc agaaaatact agagattatg ttttgtctaa aataaattct
      961 tatgaggaga taaaaaatgg caacagaaat atttactgta aaaattacac ccttagaggc
     1021 acaaaaaatg ataaaagaaa atcttgatgc agatttagtt tttagtgatt cttataattt
     1081 aggagatgat aaatttatac taattacaac ttttgagaag tattatgcaa gaaataatag
     1141 tgatgcagga ttaatagtag tttatgaaaa taccacagga aaaacagtta ttaaagctac
     1201 ttcaacaggc agtgcaattg gaattttaaa aattgattgg ggtgcaggtg gaaatttact
     1261 taaaagagta aaaaacatac ttgctgatta tattatttaa ttattttatc taactgataa
     1321 tatgtcaaga aaatctcgta aaagaggtta agaacatttt tataatatat agataaataa
     1381 gaatttgaag gtaaagtttt taaggtataa agaaaaataa tataataaaa cgaattggct
     1441 ttataattct ttataaggca aagagcacat ttctttatat aattgttgga tattaaataa
     1501 tatgtaaata caccatttac atataaaagt ttaattaata tgttaagaga aaatgaaatg
     1561 gaaattacta aaaaatattt ttaaattgga taatggttga tattatgttt atacaaaaat
     1621 catgtagaat tttatatatt ttaaatatga tagtttaaaa ttatgaaaga atgataaatt
     1681 ccagtttgta gggtaatttt gataaataat attaataagt atgagtaaaa agtaggagca
     1741 tattaatata atgtccctac ttttttatta ttaaaattgt ttataatatc aacactacat
     1801 taaaacacaa cctaaatttg aaaaacaaat agtttagaaa tatgtacttt tttatctatt
     1861 atattctttt aaatcgaatt ttttcatctg aacataaagt ctcaaatcta tatgcgtctg
     1921 tcatatcata aaaaccaaaa aatataaagc catcacgaga agtaaattca tattgtatat
     1981 tttcaatttt caacatgttt tctacttcgc ttattttttc gctatatata atttctacca
     2041 tataatttat cattgtagaa tccctcctat taatatgaaa atatccaaat atataataa
//
LOCUS       DAEQCW010000229         2054 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.230, whole genome shotgun sequence.
ACCESSION   DAEQCW010000229 DAEQCW010000000
VERSION     DAEQCW010000229.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.230"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(229..447)
                     /locus_tag="KRO40_003599"
     CDS             complement(229..447)
                     /locus_tag="KRO40_003599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094391.1"
                     /translation="MSVLLKTKIKSYREKNLMTQGELAKSVGVRRETIVHLENGRYNP
                     SLKLAMDIAKVFDTTVEELFEFIEENNI"
     gene            complement(448..855)
                     /locus_tag="KRO40_003600"
     CDS             complement(448..855)
                     /locus_tag="KRO40_003600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094392.1"
                     /translation="MSKQQTGIKSTLISEILGISYCIGATLVNKYFFKGSSIEYLPII
                     IWVLAMGAQWVYNKKYDDLIDEASKCILSRVNDIAIKVLFFSVAIVSIFLVTLDINVS
                     NLNIGMSLLVILFIQSLLKLILFIYFDRKGIYN"
     gene            complement(941..1429)
                     /locus_tag="KRO40_003601"
     CDS             complement(941..1429)
                     /locus_tag="KRO40_003601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3841 domain-containing protein"
                     /protein_id="HBH2094393.1"
                     /translation="MKFYTIQTLEFWNNNKNNKYLSNDYSFILEDFDIPYKWMYSQMT
                     NRIYEFDDSMIWVWTKRPDLRCSGYLEKGKKGVLLEIEISEDNVLLSEFDLWHLPLMD
                     ITVELYEDEQIEKKVSWERIFDLELCSKLNEVNIEDLTLQGVTSKVPLSNVKLIKEFV
                     AK"
     gene            complement(1634..>2054)
                     /locus_tag="KRO40_003602"
     CDS             complement(1634..>2054)
                     /locus_tag="KRO40_003602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094394.1"
                     /translation="SSKTALYFIELPKIRKSSCIANRVLIWGKLIDNPSHIDIRILSK
                     TDYVIKRALDRLKELGSNEDYLLNLKRGAYIMNKSRNFKEEIFQEGIEKGIAKGKREE
                     KFNIIIKLKNKGYNLSEICDIIDDLNKSEVEKVYNQN"
BASE COUNT          687 a          344 c          177 g          846 t
ORIGIN      
        1 gcttggtttt tcatctataa gtcatttatt ctctaatcta taagcttggt ttttacctat
       61 aaatcattta ttctctaatc tataagcttt ctttttcatc tataaatcat tcattcttta
      121 atccattagc ttggtttttc atctataagt catttattct ctaatctata agcttggttt
      181 tttacctata attaattcat tctctaatgc ataagtaata catgaaattt aaatattatt
      241 ttcttcaata aattcaaata actcttctac agttgtatca aataccttag caatatccat
      301 tgccagtttt aaagaaggat tgtagcgacc attttctaaa tgtacaatag tttcacgtct
      361 tactcctact gactttgcaa gttcaccttg tgtcataagg ttcttttctc tataggattt
      421 aatttttgtc tttagtaata ctgacaccta attgtatatc ccctttctgt caaaatatat
      481 aaatagaatt aacttcaaca aggattgaat aaacaaaatg actaataaag acattcctat
      541 atttaaattt gacacattta tgtccaaagt tacaagaaat atagatacta tagctacaga
      601 aaaaaacaat acttttattg caatatcatt aactcttgat agtatacatt ttgatgcctc
      661 atcaattaaa tcatcatact ttttattata gacccactga gctcccatag ctaataccca
      721 aataattata ggaagatatt caatactact tcctttaaaa aaatacttat ttactaatgt
      781 agctccaata caataagaaa ttcccaatat ttctgaaata agtgttgatt taataccagt
      841 ttgttgttta gacatataaa atccccctta aaaagttatg tatttataac acctcttgtt
      901 ataaatatat aacttttttg aataaatttc aataaaaata ttattttgca acaaattctt
      961 ttattaattt tacattagat agaggcactt tagatgtcac tccttgcaat gtcaaatctt
     1021 ctatattaac ttcatttaat tttgaacaca gttctaagtc aaatattctt tcccaactta
     1081 ccttcttttc aatttgttca tcttcataaa gctctacagt aatatccatt aaaggtaaat
     1141 gccataaatc aaattctgat aataacacat tgtcttcact tatttctatt tcaagtaaaa
     1201 cacctttttt tcctttttct aaataaccac tacatcttaa atcaggtctc ttcgtccaaa
     1261 cccatatcat actatcatca aattcatata ttctatttgt catttgacta tacatccatt
     1321 tgtatggaat atcaaagtct tctaatataa aagaataatc atttgataga tatttattgt
     1381 ttttattgtt attccaaaat tctaaagtct gtatagtata aaatttcata tataaatcaa
     1441 cccctttgtt tttctataag aaggagatgg ttcaaacttt tattttgaat tatctccttt
     1501 atttatacac ctctttgtac ctattattta tatatctctt tatatctacc atatttaaat
     1561 aacaaagttt tatattaatt taaatttaaa agaggaagct ttgtatttat ctagtgccat
     1621 ctcaatcata gtattagttt tgattataga ctttttcaac ctctgattta ttcaaatcat
     1681 ctataatatc gcatatttca ctcaaattgt atcctttatt ttttaatttt atgatgatat
     1741 taaatttctc ttctcttttc ccttttgcaa tacctttttc gataccttct tgaaaaattt
     1801 cttctttaaa atttctactt ttattcataa tatacgcacc tctctttaaa tttaataaat
     1861 agtcctcatt actacctaat tcttttaatc tatcaagtgc tcttttaata acataatccg
     1921 ttttagatag tattctaata tctatatgag aaggattatc aataagttta ccccatatta
     1981 gaactctgtt tgctatacaa ctggatttac gaatttttgg aagttctata aaatataatg
     2041 cagttttact agaa
//
LOCUS       DAEQCW010000230         1907 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.231, whole genome shotgun sequence.
ACCESSION   DAEQCW010000230 DAEQCW010000000
VERSION     DAEQCW010000230.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1907)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.231"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            206..820
                     /locus_tag="KRO40_003603"
     CDS             206..820
                     /locus_tag="KRO40_003603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBH2094395.1"
                     /translation="MEEVIAKIITIENGFKEIENIAKKIVKNNDSKKCYYLSIYLYRS
                     EYYQVRELAVFILGFISVTISEALLFLKDNVSKDENWRVQEILAKSFDYYCSEVGYEK
                     ALPVIKEWLNSDSPNIKRAVTEGLRIWTSRDYFKSNPDVAISLLSSLKEDDSEYLRKS
                     VGNALRDISKKYPDLVKKELDSWDISNKKVEFVYKLASKCILAK"
     gene            838..1200
                     /locus_tag="KRO40_003604"
     CDS             838..1200
                     /locus_tag="KRO40_003604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBH2094396.1"
                     /translation="MKLRDEYTCPLELTHDMIKGKWKSIILWRLRIGPTSLSKLEKEI
                     NGINQKMLLEQLKELIEFGLVDKKTYEGYPLKVEYSLTPIRGKQILDALAIMQDIGIS
                     FMLDNGMEDILKEKGVLK"
     gene            1306..1803
                     /locus_tag="KRO40_003605"
     CDS             1306..1803
                     /locus_tag="KRO40_003605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="HBH2094397.1"
                     /translation="MKVTSTGIVNGVIEDKYGKRGTQFNEGGMPTYSLPLKFEDAPKN
                     TVSFAVFLEDKDSVPVCGFAWIHWLAVNITKDELNENESVTATDFVQGTTSWHGKLGG
                     LDRLEASVYGGMAPPDRPHVYEIHVFALDTILDLEKGFYMNEFFKAIEGHVLDTFTLK
                     GSYSN"
BASE COUNT          726 a          213 c          326 g          642 t
ORIGIN      
        1 taaatacaac tttataatat aaaacttata ataaaagtaa atttatatgt taaatgaggt
       61 tgatttttta ttatttttta tttatgctag tactaaagac ttgcaaacgt tttttgacaa
      121 gtctttattt tgtctaaatt aaacaaactt ttttacaaat aaatacataa aatttaaact
      181 aatctattta ttggaggaga taaaattgga agaagtaatt gcaaaaatta ttactataga
      241 aaatggattc aaagaaattg aaaacattgc taaaaaaatt gtaaaaaata atgactcaaa
      301 aaagtgttat tatctatcaa tctacttata taggtcagaa tattatcaag taagagaatt
      361 ggctgtgttt atacttggtt ttatatcagt aactatttct gaagctttgt tatttttaaa
      421 agataatgtg agtaaagatg aaaactggag agtacaagaa atactagcta aatcatttga
      481 ttattattgc agtgaagtag gatatgaaaa ggctcttcct gttataaaag aatggcttaa
      541 ttctgatagt ccaaacataa aaagggctgt gacagaaggt cttcgaattt ggactagtag
      601 agactatttt aaatctaatc ctgacgttgc tatatcacta ctttctagtt taaaagaaga
      661 tgatagcgaa tacttgagaa agtctgtagg taatgctctt agagatataa gtaaaaaata
      721 tccagattta gtaaaaaaag aattagattc atgggatata tcaaataaaa aagttgagtt
      781 tgtatataag cttgcttcaa aatgtatctt ggcaaagtaa aatggaggtg aacttatttg
      841 aaacttcgtg atgagtatac ttgcccatta gaactaacac atgatatgat aaaaggcaaa
      901 tggaaatcta ttatattatg gagattacgc ataggaccaa cttccttatc aaaacttgaa
      961 aaggaaatca atggtattaa tcaaaagatg ttacttgaac aacttaaaga attaattgaa
     1021 tttggtcttg tagataaaaa gacatatgaa ggttacccac ttaaagtcga atactcactt
     1081 acacctattc gagggaaaca aatattggat gctttggcta taatgcaaga tataggaatt
     1141 agctttatgt tggataatgg tatggaagat attcttaagg aaaaaggtgt tttaaagtaa
     1201 atagataccc acaaaaaagt aagtaattta ccattatttt caactggtat ataattaaat
     1261 tatagatata ttctattaat ttattataat aggaggtaaa ttattatgaa agtaactagt
     1321 acaggtatag taaatggtgt tatagaagat aaatacggta aaagaggaac tcagttcaat
     1381 gaaggtggta tgcctaccta ttcactacct ctaaagtttg aagatgctcc aaagaataca
     1441 gtatcctttg ctgtattttt agaagataaa gactctgttc ctgtatgtgg gtttgcatgg
     1501 atacattggt tagctgtaaa tataacaaaa gatgagttaa atgaaaatga aagtgtaaca
     1561 gctactgatt ttgtacaagg gactactagt tggcatggta aactaggagg tcttgacaga
     1621 ttagaggcca gtgtatatgg tggaatggct cctccagaca gacctcatgt ctatgaaata
     1681 catgtatttg cacttgatac tatccttgac cttgaaaaag gattctatat gaatgaattt
     1741 ttcaaagcta ttgaagggca tgttttagat acatttacac taaaaggaag ttattctaat
     1801 taattaggtt gactatagct aatcattaat taaatgctac atttaattga tgattagctt
     1861 aattgttatt agaatatttt ctgcacttta tcttaatata tatttta
//
LOCUS       DAEQCW010000231         1790 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.232, whole genome shotgun sequence.
ACCESSION   DAEQCW010000231 DAEQCW010000000
VERSION     DAEQCW010000231.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1790)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.232"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..597
                     /locus_tag="KRO40_003606"
     CDS             <1..597
                     /locus_tag="KRO40_003606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBH2094398.1"
                     /translation="GLIKESSGQVLLNKHNLSNLAEHRRTQIVSRVFQDPSLGTCPSM
                     TVRENLSLALNKGKLLNLRKCLRYKRDFLENLLEGVSLDLKKYLDVQVKFLSGGQRQS
                     LSLIMSCLTNPSVLLLDEHTAALDPKTSNEVIELTNKIVREKNITTLMVTHNLKHALH
                     YGDRLIMLHKGEVVLDVKGKEKEQLTVEEILEKFEYAV"
     gene            728..1750
                     /locus_tag="KRO40_003607"
     CDS             728..1750
                     /locus_tag="KRO40_003607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBH2094399.1"
                     /translation="MINKKRLASLILAGALSISMLTGCSQGGDSGNSKQESNSKGKEV
                     KKIGITQLVEHPALDATRTGFVKALEKNGFKDGENIDIDFQNAQNDMPTTQSIASKFA
                     SDKKDLIFAISTPSAQAAFNATKDIPILITAVSDPVAAGLVKTLEKPGTNVSGTSDFV
                     SVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKNGFKVVEKGITTSNE
                     VNQGISSLVGKIDVLYVPTDNLVASSMPIVSKIATENKIPVIAAESGPVEKGALACQG
                     INYEKLGYKTGEMAVKILNGESVSDMPVATSDDTDIIVNEDILKALGMEKPSNENISY
                     VKTKQE"
BASE COUNT          685 a          242 c          303 g          560 t
ORIGIN      
        1 gggcttataa aagaatcttc tggtcaagta ttattaaata aacataactt gtctaattta
       61 gctgaacaca gaagaactca aatagtaagt agagtttttc aagacccaag tcttggaact
      121 tgcccttcta tgactgttag agaaaacttg tctttagctc ttaacaaagg aaaactatta
      181 aatctaagaa aatgtcttcg ttacaaaaga gatttcttag aaaatttatt ggaaggtgta
      241 tctcttgatt taaaaaaata ccttgatgtt caagtaaaat ttttatcagg aggtcaaaga
      301 caatcattat cactaattat gtcgtgctta acaaatccat cagttttatt acttgatgaa
      361 catacagcag cacttgaccc aaaaacatca aatgaagtaa ttgaattgac taataagatt
      421 gtaagggaaa aaaatataac tacacttatg gttactcaca acttaaaaca cgctcttcat
      481 tatggtgata gattgataat gcttcataag ggtgaagttg tattagatgt aaaaggtaaa
      541 gaaaaagaac aattaacagt tgaagaaatc ttagaaaaat ttgaatatgc agtttaaaat
      601 aatatatcta ttgtattaaa ctcggcttta aaataaagtt aaaattacaa taattatggt
      661 tactttgtaa taattcatat gaatatatga acatatataa caataaattt ttgaggggga
      721 tataaaaatg attaataaaa aaagattggc aagtttgatt ttagctggtg ctcttagtat
      781 atctatgctt acagggtgtt cacaaggagg agactctggt aattcaaaac aagaaagtaa
      841 ttctaaaggt aaagaagtta aaaaaattgg tataactcaa ctggttgaac atccagcatt
      901 agatgccact aggacaggtt ttgtaaaagc attagaaaag aacggattta aagatggaga
      961 aaatattgat atagacttcc aaaatgctca aaatgacatg cctactacac aaagtattgc
     1021 gagtaaattt gcatctgata agaaggactt aatatttgct atatctactc catcagctca
     1081 ggcagcattt aatgctacta aagatatacc tatacttatt actgctgtga gtgaccctgt
     1141 tgctgctgga ttagttaaaa ctcttgaaaa gccaggcaca aatgtatctg gaacatcaga
     1201 ttttgtttct gtagacaaag gtttagaact tcttaaaata tttgctccta aggcaaaaac
     1261 tataggagtt atgtacaata ctagtgaagt aaattccaaa gttcaagttg atgctttaaa
     1321 agaatatgca tctaaaaatg gatttaaagt tgttgaaaaa ggtataacta cttcaaatga
     1381 agttaaccaa ggtatttcta gtttagttgg caaaatagac gtattatatg tccctacaga
     1441 taacttagtg gcttcttcta tgcctatagt ctctaaaata gctactgaga ataaaatacc
     1501 tgttatagca gctgaatctg gtccagttga aaaaggtgct cttgcttgtc aaggtatcaa
     1561 ctacgaaaaa ctaggttaca aaacaggtga aatggcagtt aaaattttaa atggcgaatc
     1621 agtatctgat atgcctgtgg ctacatcaga tgatacagat atcattgtta atgaagatat
     1681 attaaaagct ttaggtatgg aaaaaccttc taatgaaaat atttcttatg taaagactaa
     1741 acaagaatag aaagatattt tctatatacg attaatatgc ctgtttctat
//
LOCUS       DAEQCW010000232         1766 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.233, whole genome shotgun sequence.
ACCESSION   DAEQCW010000232 DAEQCW010000000
VERSION     DAEQCW010000232.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.233"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>1766
                     /locus_tag="KRO40_003608"
     CDS             <1..>1766
                     /locus_tag="KRO40_003608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2094400.1"
                     /translation="YEDYEYQLPKKKLNKETLIKYYDLIRPTRCVIEESQRYLRLEHE
                     DKESYVSYFTVNAIVGELDFPSSEIFYFQQQQFTFPVDTSMNVEIVENRKALTTVRNK
                     KKELKDLDNHAYQAGSETSSNVVDALDSVDELETDLDQSKESMYKLSYVIRVSAPDLD
                     ELKRRCDEVKDFYDDLNVKLVRPAGDMLGLHSEFLPASKRYINDYVQYVKSDFLAGLG
                     FGATQQLGETTGIYMGYSVDTGRNVYLQPSLASQGVKGTVTNALASAFVGSLGGGKSF
                     CNNLLVYYSVLFGGQALLLDPKSERGNWKETLPEIAHEINIVNLTSDKDNAGLLDPFV
                     IMKNVKDAESLAIDILTFLTGISSRDGEKFPVLRKAVRSVTQSDKRGLLHVIDELRRE
                     DTPVSRNIADHIDSFTDYDFAHLLFSDGTVENAISLDNQLNIIQVADLVLPDKDTTFE
                     EYTTIELLSVSMLIVISTFALDFIHSDRSIFKIVDLDEAWAFLNVAQGETLSNKLVRA
                     GRAMQAGVYFVTQSSGDVSKESLKNNIGLKFAFRSTDINEIKQTLEFFGIDKDDENNQ
                     KRLRDLENGQCLLQDLYGRVGVV"
BASE COUNT          521 a          351 c          432 g          462 t
ORIGIN      
        1 tatgaagatt atgagtacca gctaccaaag aagaaattga acaaagaaac gctgataaaa
       61 tactacgacc ttatccgtcc gacaaggtgt gtgattgagg aaagccagcg gtatttaaga
      121 ttggaacatg aggacaagga aagctatgtg tcctatttta ccgtcaatgc gattgtcggc
      181 gagcttgatt ttccgtcaag tgaaatcttc tatttccagc aacagcaatt cacattcccc
      241 gttgatactt ctatgaatgt agaaatcgtg gaaaatcgga aagcattaac gacagtccgc
      301 aacaagaaaa aggaattgaa agaccttgac aatcacgctt atcaagcagg aagtgaaacc
      361 agctcaaatg tggtggacgc attagatagc gtggacgagc tggaaacgga cttagaccag
      421 agcaaagaaa gtatgtataa gttaagctac gtcatacggg tgtctgcacc cgatcttgac
      481 gagctgaaac gccgttgtga tgaagtcaag gacttttacg acgacctcaa tgtaaagctg
      541 gtgcgtcctg ctggggatat gctggggctt cattctgaat ttttaccagc cagcaagcga
      601 tatatcaatg attatgtgca gtatgtaaaa tcagattttc tagcagggct tggttttggt
      661 gcgacacagc agttaggaga aactacgggt atctatatgg gctattctgt tgatacggga
      721 agaaatgtgt acctgcaacc gtcccttgcc agtcaaggtg taaaaggtac agttaccaac
      781 gctttagcgt ctgcttttgt cggttcgctt ggcggtggga aatcgttctg taacaatctt
      841 ctggtgtatt attcggtgct gtttggcggt caagcacttc tgttagaccc taaaagtgag
      901 cgtggcaact ggaaagaaac gctcccagaa atcgcccatg aaatcaatat cgtaaaccta
      961 acaagcgaca aggacaatgc aggacttctt gacccgtttg tgattatgaa gaatgtaaaa
     1021 gacgctgaaa gtctggcaat cgacatctta acattcctta cgggtatttc ttcaagggac
     1081 ggagaaaagt tccccgtact tcgtaaggcg gtgcgttccg ttacccagag cgacaaacgg
     1141 ggcttgcttc atgtgataga cgagttacgc cgtgaagata cgccagtatc aagaaatatc
     1201 gcagaccata tcgacagctt cacggactac gactttgcac acctgctgtt ttcagacggt
     1261 acggtggaaa atgctatcag ccttgataac cagctcaata tcattcaagt agcggactta
     1321 gtattgccag ataaggacac gacctttgag gaatacacga ccattgaatt attgtcggtg
     1381 tctatgctga ttgtgattag tacctttgct cttgatttta tccattcaga cagaagcatt
     1441 tttaagattg tcgatttgga cgaagcgtgg gcgttcttaa acgtggcaca aggcgaaact
     1501 ttatcaaata agctggttcg tgctggacgt gctatgcagg caggcgttta ttttgttaca
     1561 caatcttctg gggacgtgtc aaaagaaagt ctgaaaaaca atatcggctt gaagtttgcc
     1621 tttagaagca ccgacatcaa cgagataaaa cagaccttag agtttttcgg tatcgacaag
     1681 gacgatgaga acaaccagaa acgcttgcgt gatttggaaa acggacaatg cttattgcag
     1741 gacttatacg ggcgtgtcgg tgtggt
//
LOCUS       DAEQCW010000233         1766 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.234, whole genome shotgun sequence.
ACCESSION   DAEQCW010000233 DAEQCW010000000
VERSION     DAEQCW010000233.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.234"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>1766
                     /locus_tag="KRO40_003609"
     CDS             <1..>1766
                     /locus_tag="KRO40_003609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBH2094401.1"
                     /translation="YEDYEYQLPEKKLQKETLIKYYDLIRPTRCVIEESQRYLRLEHE
                     DKESYVSYFTVNAIVGELDFPSSEIFYFQQQQFTFPVDTSMNVEIVENRKALSTVRNK
                     KKELKDLDNHAYQAGSETSSNVVDALDSVDELETDLDQSKESMYKLSYVIRVSAPDLD
                     ELKRRCDEVKDFYDDLNVKLVRPAGDMLGLHSEFLPASKRYINDYVQYVKSDFLAGLG
                     FGATQQLGENTGIYMGYSVDTGRNVYLQPSLASQGVKGTVTNALASAFVGSLGGGKSF
                     CNNLLVYYSVLFGGQAVILDPKSERGNWKETLPEIAHEINIVNLTSDKDNAGLLDPFV
                     IMKNVKDAESLAIDILTFLTGISSRDGEKFPVLRKAVRSVTQSDSRGLLHVIDELRRE
                     DTPISRNIADHIDSFTDYDFAHLLFSDGTVENAISLDNQLNIIQVADLVLPDKDTTFE
                     EYTTIELLSVSMLIVISTFALDFIHSDRSIFKIVDLDEAWAFLNVAQGETLSNKLVRA
                     GRAMQAGVYFVTQSAYDVSKESLKNNIGLKFAFRSTDINEIKQTLEFFGIDKEDENNQ
                     KRLRDLENGQCLLQDLYGRVGVV"
BASE COUNT          518 a          358 c          426 g          464 t
ORIGIN      
        1 tatgaagatt atgagtacca gctaccagag aagaaattgc agaaagaaac gctgataaaa
       61 tactacgacc ttatccgccc gacaaggtgt gtgattgagg aaagccagcg gtatttacga
      121 ttggaacatg aggacaagga aagctatgtg tcttacttta ctgtcaatgc gattgtaggc
      181 gagcttgatt ttccgtcgtc tgaaatcttc tatttccagc aacagcagtt tacattcccc
      241 gttgatactt ctatgaatgt agaaatcgtg gagaacagaa aggctcttag cacagtaaga
      301 aataagaaaa aggaattgaa agaccttgac aatcacgctt atcaagcagg aagtgaaacc
      361 agctcaaatg tggtagacgc tttagacagc gtggacgagc tggaaacaga cttagaccag
      421 agcaaagaaa gtatgtataa gttaagctac gtgatacggg tgtctgcacc cgatcttgac
      481 gagctgaaac gccgttgtga tgaagtcaag gacttttacg acgacctcaa cgtaaagctg
      541 gtgcgtcctg ctggggatat gctggggctt cattctgaat ttttacctgc cagcaagcga
      601 tatatcaatg actatgtgca gtatgtaaaa tcagacttct tggcagggct tgggtttggt
      661 gctacccagc agttagggga aaatacgggt atctatatgg gctattccgt tgatacggga
      721 agaaatgtgt acctgcaacc gtcccttgcc agtcaaggtg taaaaggtac agttaccaac
      781 gcccttgcgt ctgcttttgt cggttcgctt ggcggtggaa agtcgttctg caacaatctt
      841 cttgtgtatt attcggttct ctttggggga caagcggtta tcttagaccc aaaatcagag
      901 cgtggcaact ggaaagaaac acttccagaa atcgcacatg aaatcaatat cgtaaatctt
      961 accagcgaca aggacaatgc aggacttctt gacccattcg tgattatgaa gaatgtaaaa
     1021 gacgctgaaa gtctggcaat cgatatctta acattcctta ctggtatttc ctctagggac
     1081 ggcgaaaaat tccccgtact tcgtaaagcg gtacgctccg ttacccagag cgacagtcgg
     1141 ggcttgctcc atgtgataga cgagctacgc cgtgaagata cgcccatatc aagaaatatc
     1201 gcagaccata tcgacagctt cacggactac gactttgcac acctgctgtt ttcagacggt
     1261 acggtagaaa atgctatcag tctggataac cagctcaata tcattcaagt agccgacctt
     1321 gtgttgccag ataaggacac gacctttgag gaatacacga ccattgaatt gttgtctgtg
     1381 tctatgctga ttgtgattag tacctttgcc cttgatttta tccattcgga cagaagcatt
     1441 tttaagattg tagatttgga cgaagcatgg gcgttcttaa atgtggcaca aggcgaaacc
     1501 ttatcaaata agctggttcg tgctggacga gctatgcagg caggcgtcta ttttgttacc
     1561 cagtctgcct atgatgtttc aaaggaaagt ctgaaaaata atatcggctt gaaatttgcc
     1621 tttagaagta ccgatataaa cgagattaaa cagaccttag aatttttcgg tatcgacaaa
     1681 gaggacgaaa acaaccagaa aaggcttcgt gatttggaga acggacaatg cttgttgcag
     1741 gacttatacg ggcgtgtcgg cgtagt
//
LOCUS       DAEQCW010000234         1754 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.235, whole genome shotgun sequence.
ACCESSION   DAEQCW010000234 DAEQCW010000000
VERSION     DAEQCW010000234.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1754)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.235"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(20..661)
                     /locus_tag="KRO40_003610"
     CDS             complement(20..661)
                     /locus_tag="KRO40_003610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SdpI family protein"
                     /protein_id="HBH2094402.1"
                     /translation="MKKAINKQFILSTLICFIPFIVSIYFYNRLPNEVAIHFDNYGNP
                     DNYAPKVIAAFGVPLLMLCIHLYTWFRLENEPKKANFSNVIQNLSKWGVAILSVIIQI
                     MMVLYSTGVSLESNFYTGLILGIIVILFGNYLPKCKRNYSVGIILPWTLNDEDNWNKT
                     HHLAGWIWLIGGILLIINAFINIPFYNIFVIFVIVILPFIYSYLMYKISGKNN"
     gene            complement(642..935)
                     /locus_tag="KRO40_003611"
     CDS             complement(642..935)
                     /locus_tag="KRO40_003611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBH2094403.1"
                     /translation="MGFPETFKALSDPIRREILVMLRENKMSAGEISEKFNMTNATIS
                     YHLSQLKKAGLIFETKYKNFIFYEINISVFEEVMLWFSQFMEKGEKDNEKSDK"
     gene            1328..1378
                     /locus_tag="KRO40_003612"
     CDS             1328..1378
                     /locus_tag="KRO40_003612"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094404.1"
                     /translation="MTEYIYYYNNKRIKKN"
BASE COUNT          663 a          258 c          168 g          665 t
ORIGIN      
        1 attatattga ttaattatat tagttatttt tacctgaaat tttatacatc aaataagaat
       61 atataaatgg tagtattaca attacaaaga ttacaaagat attataaaaa ggaatattaa
      121 taaatgcatt aataattaat aatattccac caataagcca aatccatcca gctaaatggt
      181 gtgtcttatt ccaattatct tcatcattaa gagtccatgg caaaattatt cctactgagt
      241 aatttcgttt acatttagga agatagtttc caaataaaat aactattatt cctaaaatta
      301 atcctgtata aaaattagac tccaaactaa ctcctgttga atataaaacc atcattattt
      361 gtataattac tgaaagtata gcaactcccc attttgataa attttgtata acatttgaaa
      421 aattagcttt cttaggctca ttctcaagtc taaaccatgt atacaaatgg atacatagca
      481 ttaacaatgg tacaccaaaa gctgctataa cctttggagc ataattatct ggatttccat
      541 aattatcaaa atgaattgca acttcatttg gtaatctatt ataaaaatat attgatacaa
      601 taaatggtat aaaacatatt aaagtagata aaataaattg tttatttatc gcttttttca
      661 ttatcttttt ctcccttctc cataaattgt gaaaaccaaa gcataacctc ttcgaaaact
      721 gaaatattta tttcgtagaa aataaagttc ttatactttg tttcaaatat gagtcctgcc
      781 ttttttagtt gagatagatg ataagaaatt gtagcattcg tcatattaaa tttttcacta
      841 atttctcctg ctgacatttt attctccctc aacataacca atatttctct tcttataggg
      901 tctgaaagag ctttgaatgt ttctggaaac cccaacacca tcacctcgct atttagaatt
      961 tcatctaaat agaatataac ataacatcca ttttatttca atagctattt agaaattttt
     1021 ctaaatagct atttctaaat agttattgaa aattttcata ttaagattct caatttactt
     1081 aagtcgcttt tatttaatct tactttatct aattttttta acttaacaaa agtgtattgc
     1141 accataattg ttaaagcaaa aacctaatga ctgagatact tatatatata acaatacttt
     1201 taattttaaa ttaaaagtag ctaaacccaa tttaaaaagt agttaagtcc tatttaaata
     1261 gaaaagaatg aaacgagaaa tatactgtat aaaagtacat aaaaacatct actaattaga
     1321 tacaactata acagaatata tttattatta taataacaaa agaataaaaa aaaattaatt
     1381 tagcataacc ttgttaaata tagatttgaa tatgaattta aagttatgta aaattaaaaa
     1441 tacaggaatg aaaattccat tcctgtataa aatctaactt ttgagtctca gtacaatctt
     1501 attttgagac aatctttttt gttttatatt ttcttatatt taaaatataa cgcatatctt
     1561 atgcaacata ttcatatttt tctttatatt ctttcatcgc atcattccaa gcgtcttgta
     1621 ctgttacacc tcttttatta gcaatttttt gtgccagttc aattatcttc atagctcttc
     1681 ttgatatgtt cataaacatt cctcctacaa attaccatat atttcatata tataaatcaa
     1741 ggttatattt ttat
//
LOCUS       DAEQCW010000235         1701 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.236, whole genome shotgun sequence.
ACCESSION   DAEQCW010000235 DAEQCW010000000
VERSION     DAEQCW010000235.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1701)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.236"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            128..862
                     /locus_tag="KRO40_003613"
     CDS             128..862
                     /locus_tag="KRO40_003613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBH2094405.1"
                     /translation="MKQNKYDDDRFFNKYSKMERSTNGLAGAGEWHVLKKMLPDFKGK
                     RVLDLGCGFGWHCQYAVENGAISAVGVDISEKMLKEARNKTQLDNINYICMPIEDINF
                     PKDSFDVVISSLAFHYIQSFEDICKNISNCLSNKGNFAFSVEHPIFTAYGSQEWYCDK
                     DGNNLHWPVDRYFEEGVRRSNFLGEEVIKYHKTLTTYLNTLMKTGFEILEIIEPQPEE
                     KLLDTIPDMKDELRRPMMLLVSAKKR"
     gene            complement(1005..1496)
                     /locus_tag="KRO40_003614"
     CDS             complement(1005..1496)
                     /locus_tag="KRO40_003614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBH2094406.1"
                     /translation="MNNQQQEVYKKLDELSIPYEAVNHPPVYTIEEMEELKTLHMEFV
                     VKNLFLRDAKGKEHFLVVLGKDKKADLKDIRQQIDSKPLSFASEERLQKYLKLTKGAV
                     TPFGILNDKEAVVKVVFDKDLLKMDKIGIHPNDNTATVFLKFEDMKKLIEENGNEIYY
                     VEV"
BASE COUNT          636 a          200 c          245 g          620 t
ORIGIN      
        1 ttcatttata ttattaaaaa atttatttat agaaactttt attattttat ataaaagtga
       61 taaaaactta tattttgtgt ttagtagagt gttgctaagt gaatatattt aaaatggagg
      121 aaactttatg aaacaaaata aatatgatga tgatagattt tttaataagt acagtaaaat
      181 ggaacgttct acaaatggat tagcaggtgc tggagaatgg catgttttaa aaaaaatgtt
      241 acctgatttc aaaggaaaaa gagttttaga tttaggatgt ggatttggat ggcattgtca
      301 atatgcagtt gagaatggag caatttctgc tgttggagtt gatatttcag aaaaaatgtt
      361 aaaagaagct agaaacaaaa cgcaacttga taatataaat tacatatgta tgcctattga
      421 agatattaat tttccaaaag atagttttga tgtagttatt agttccttgg catttcatta
      481 tattcaatca tttgaagata tatgtaagaa tataagtaat tgtctttcaa ataaaggtaa
      541 ttttgcattt tctgttgaac atcctatatt tactgcatat ggaagtcaag agtggtactg
      601 tgataaagat ggcaataatc tacactggcc agtagataga tattttgaag aaggagtacg
      661 taggtcaaat tttctaggag aagaggttat aaaatatcat aaaacattaa caacttattt
      721 aaatacgtta atgaaaacag gatttgaaat attagaaatt attgaacctc aaccagaaga
      781 aaaactgtta gatacaattc ctgatatgaa agatgagcta cgtagaccta tgatgttact
      841 tgtatctgca aaaaaaagat aagtaaatat aaataatcat tattgtagaa aaaaagttgt
      901 agaaaataat tacactaatg gagatgatta taccagtggt attaattaca ccagtagtaa
      961 ggaggcaaaa gcattcgttg cttttgccat tttttaagtt gcaattatac ttctacgtag
     1021 tatatttcgt ttccattttc ttctataagc tttttcatat cttcaaattt taaaaataca
     1081 gtagcagtat tatcatttgg atgtatacct attttatcca tttttaataa atccttatca
     1141 aatacaactt ttacaacagc ctctttatca tttaatatac caaaaggagt cacagctcct
     1201 ttagtaagtt tcaagtattt ttgaagtctt tcttctgatg caaaactaag aggtttacta
     1261 tcaatttgtt gacgaatatc ttttaaatct gcttttttgt ctttacctaa tacaactaaa
     1321 aaatgttctt ttcctttagc atcacgaaga aataggtttt ttacaacaaa ttccatatgt
     1381 aatgttttta attcttccat ttcttcaatt gtataaactg gtggatgatt tacagcctca
     1441 taaggtatgc ttaactcatc taatttttta tatacttcct gttgttgatt gttcatgatt
     1501 tcctcccatt agaaatttat tttatatata aataatatta tcacagaaaa ctttaaaaga
     1561 aaacgtttta tataatatag acaatagatt atatttttat aaagaagcaa gaatactcaa
     1621 taaaacttaa agaaattaaa caatttctaa aaataccttg aaaatagaac cttatttgcc
     1681 atttataaat tatataaaaa g
//
LOCUS       DAEQCW010000236         1638 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.237, whole genome shotgun sequence.
ACCESSION   DAEQCW010000236 DAEQCW010000000
VERSION     DAEQCW010000236.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1638)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.237"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            44..853
                     /locus_tag="KRO40_003615"
     CDS             44..853
                     /locus_tag="KRO40_003615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBH2094407.1"
                     /translation="MKDYYKIGEISKIYGIGRDSLMYYEEIGILRPVRDINGYRMYNI
                     SDIWKLNLIKEFRSLNFPMKKIKEYLDDRSIESTKNILNEELDLIDKKIAEFISHKEN
                     IIKRLSSIESVIQNTKIDEIEVVYIEKRKALELNADIKRDEDFDFLIQKLQKEYEDRF
                     NILGNNNIGSAFSTEAINKGIFNEFKSVFCFLESNEKVYNIVFDEGYYVTLNYTGSNS
                     NNKIYMEKVFKFIEENNYKIIADPIEIYKIDIHETGIVEEFVTEIQVPITK"
     gene            987..1226
                     /locus_tag="KRO40_003616"
     CDS             987..1226
                     /locus_tag="KRO40_003616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094408.1"
                     /translation="MKCSNCGSVNIEKGILTTGGIYAETIGLKYRGDGKLDKVINKTF
                     PVQSTIYSDLCLDCGEIVRTYIKDNTDRNWCKDKK"
     gene            complement(1414..1590)
                     /locus_tag="KRO40_003617"
     CDS             complement(1414..1590)
                     /locus_tag="KRO40_003617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094409.1"
                     /translation="MFRDEMDKCTHMLTAYISSLYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
BASE COUNT          701 a          137 c          265 g          535 t
ORIGIN      
        1 gatttaaaat aaaaataaga tttcggagga gtttattata taaatgaaag attactataa
       61 aataggagag atatctaaaa tatatggaat aggtagagat tcattaatgt attatgaaga
      121 aataggcatt ctaagaccag ttagagatat aaatggatat agaatgtata atatatcaga
      181 tatatggaaa ttaaatttaa taaaagaatt tagaagcttg aactttccaa tgaagaaaat
      241 aaaagaatac ctagatgaca gaagtataga gtctacgaaa aatattttaa atgaagaact
      301 cgatttaatt gataaaaaaa tagctgaatt tataagccat aaggaaaata ttataaaaag
      361 attgagttca attgaaagtg taattcaaaa tacaaaaata gatgagatag aggttgtata
      421 tatagaaaaa agaaaagctt tagaattaaa tgctgatata aagagggatg aagacttcga
      481 ttttttaatt caaaaacttc agaaagaata tgaagataga tttaatatac ttggaaacaa
      541 caatattggt tctgcctttt ctactgaagc aattaataaa ggtatattta atgagtttaa
      601 atctgtattt tgttttctgg aaagtaatga gaaagtatat aatatagttt ttgatgaagg
      661 atattatgta actttaaatt atactgggag taattctaat aataagatat atatggagaa
      721 ggtgtttaaa tttatagaag aaaataatta taagataatt gctgacccta tagaaatcta
      781 taagatagat atacatgaga ctggaattgt agaggagttt gtaacggaaa ttcaagttcc
      841 tataactaaa tagctatatt tcaatggatt agatggtaaa tagaatgaaa aaatgttgat
      901 ttgccactgt gttataaaat cggtagcaaa ttatatttta aattataaga tagcatgaaa
      961 aaataattgt ttagggggtt ataaatgtga aatgttctaa ttgtggaagt gtaaatattg
     1021 aaaagggaat tttaacaact ggtggcatat atgctgaaac tattggatta aaatatagag
     1081 gagatggaaa attagataaa gttataaata aaacttttcc agtacaatct actatatatt
     1141 cagatttatg tttagattgt ggagaaatag ttagaaccta tataaaggat aatactgata
     1201 ggaattggtg taaagataag aaatagaata atttttgaag tatattaata tttgaagttg
     1261 aattttatta aagatacaag tgaaaaagta taaatgggaa gaaattgtta tatggaagaa
     1321 aactttgcat ataggggaga ttagtttttt aatataataa catttttaaa tgtagataaa
     1381 actaaaaagg gttctctaga aaacaatttc tatttaatta tacttactta ccaataccat
     1441 cacttgatgt aaacaagatt ctactacatt ttctccgtac tctagtataa aatcatctag
     1501 ctgtgtatct ataaaatcac aataatcata taaactactg atataagcag ttaacatgtg
     1561 tgtacattta tccatttcat ctctaaacat atatattact atccccctaa aaaactttca
     1621 taaaacaaaa agaacaat
//
LOCUS       DAEQCW010000237         1629 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.238, whole genome shotgun sequence.
ACCESSION   DAEQCW010000237 DAEQCW010000000
VERSION     DAEQCW010000237.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1629)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.238"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(224..1072)
                     /locus_tag="KRO40_003618"
     CDS             complement(224..1072)
                     /locus_tag="KRO40_003618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBH2094410.1"
                     /translation="MKNLKIICDSLSDVPKDLLDKYDIDIVSLTVILEEREYKDRIDI
                     SGDEFYKRLREENVYPKTSQATYAQFKEIFEKYTNEDREILYIAGSATATGTYQSAVM
                     AKNDVDGKIYTYDSNLLCMGTGLLVIKAGELASEGKSVAEILPVLDELKEKAFVIFSV
                     DTLEYLQKGGRISSTKAAIGSILNIKPILEIRDGLVSQISQVRGKKNVISKMMELIKS
                     NCGDDLSDQIVYIGYSDDFKEKEQLSKVMQDELRPKEIRFFQIGVCIGAHAGPGVTGI
                     ICLKNK"
     gene            complement(1108..1578)
                     /gene="trmL"
                     /locus_tag="KRO40_003619"
     CDS             complement(1108..1578)
                     /gene="trmL"
                     /locus_tag="KRO40_003619"
                     /EC_number="2.1.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (uridine(34)/cytosine(34)/5-
                     carboxymethylaminomethyluridine(34)-2'-O)-
                     methyltransferase TrmL"
                     /protein_id="HBH2094411.1"
                     /translation="MSLNIVLVEPEIPQNTGNIIRTCAATGSTLHLVKPLGFSLDDKH
                     LKRCGLDYWDIADIQYYDSFEELQEKYPNSKYFFSTTKAKQSHSDVKYEENCFIVFGK
                     ETKGLPEPLLKANMDTCIRVPMLDVEKARSLNLSNSVAIVVYEALRQIGYPNMR"
BASE COUNT          520 a          314 c          160 g          635 t
ORIGIN      
        1 aattttttta tatacaattt acaagtacat tttgaaattt ttttaataaa tcttactata
       61 aaaaagtgtg caatagattc ttatctattt acacacttcc ctacaaacta aatctaatat
      121 atcaacactt aatttcatcc aaaataaatc caatttaaca tctcaataat taatattcta
      181 tcctaattta ataaaaaaat aaataatgtc atccaaaaat atattattta ttttttaagc
      241 atatgatacc agtaacacca ggaccagcat gtgcacctat acacacacca atttggaaaa
      301 atctaatttc tttaggtctt aattcatctt gcataacctt agataattgt tccttttcct
      361 taaaatcatc actatatcct atatacacaa tttggtctga taaatcatca ccacaatttg
      421 attttatcaa ttccatcatc ttagaaatta cattcttctt tcctcttact tgagatattt
      481 gcgaaactaa tccatctctt atttcaagaa tcggttttat atttaatata cttcctattg
      541 ctgccttagt agatgatatt ctacctccct tttgtaaata ttccaatgta tctactgaaa
      601 atataacaaa agccttctct tttaattcat ccaaaacagg caatatttca gcaacagact
      661 ttccttcact tgcaagttct cctgctttta ttacaagtaa accagttccc atacaaagca
      721 agttagagtc atatgtatat attttaccat ctacatcatt ctttgccatt acagcacttt
      781 gatacgtacc tgtagctgtg gcagaccctg ctatataaag tatctctcta tcctcatttg
      841 tatatttctc aaaaatttcc ttaaattggg cataagtagc ttgagaagtt tttggatata
      901 cattttcttc tctaagcctt ttataaaatt catctccaga tatatcaatt ctatccttgt
      961 attctctttc ctccagtata actgttaatg aaactatatc tatatcatat ttatctaaca
     1021 aatcttttgg cacgtccgat aaactgtcac agattatctt tagatttttc attaagtatg
     1081 ctcctttctc atttaggctt gttaaaacta cctcatattt gggtatccta tttgtcttaa
     1141 agcctcgtac actacaatag caactgaatt tgataaattt aatgacctag ctttttcaac
     1201 atccaacata ggcactctaa tacaagtatc catatttgct ttcaacaaag gttctggtaa
     1261 tccctttgtt tctttcccaa atactataaa acaattttct tcatatttca catctgaatg
     1321 tgactgttta gcctttgttg tagaaaaaaa gtatttacta tttggatact tttcttgtaa
     1381 ttcttcaaag ctatcgtaat attgtatatc agctatatcc caatagtcaa gcccacatct
     1441 ttttaggtgt ttatcatcca atgaaaaacc cagtggtttt actaaatgta aagttgaacc
     1501 tgttgctgca caggttctta ttatatttcc tgtattttga ggtatttctg gttctactaa
     1561 tactatattt aatgacattt taatcctccc taagtattgc ttttatttat caaattttat
     1621 tttataaac
//
LOCUS       DAEQCW010000238         1610 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.239, whole genome shotgun sequence.
ACCESSION   DAEQCW010000238 DAEQCW010000000
VERSION     DAEQCW010000238.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1610)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.239"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            109..1581
                     /locus_tag="KRO40_003620"
     CDS             109..1581
                     /locus_tag="KRO40_003620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp28"
                     /protein_id="HBH2094412.1"
                     /translation="MKFYKRILTLTLSISFVFANIQLVDAISSVEKIQGKNKYEIAGK
                     IADKNAYKTAYKTAYKTAYKTAILINTSNSIADGLSASGLAGALNAPILLTEKNTIPT
                     ETSARLKNVSKVYIIGGTYSISTSVENSLKSKKMKVVRIKGNDRIKTSYNVAKEINSI
                     KKVNTVMLTNAYKGEADAISIASVAARDKAPIILTNGQSIPFSTSGLKSYVIGGTASM
                     STTLVNNTKSTRLGGSTRFETNKAIINKFYKDAREFYIAGAYELTNALVGSSLSKHGP
                     MVLVNDGSNKSILKNAKKITSIGYIDSNIVQQCLNITNGIGDINTGVVKNVKPTTKTI
                     KDGMYKVGKDISAGEYLITSNSGSYASYYEVTSDSTGNADSILSNDIFSGTRYITLKN
                     GQYIKIEDSTMTLAKYAKAQKAKNGKFGNGMYKIGLEIPAGEYIIMSNSSDAYYEVRN
                     DSLGNAEGIVTNDTFSGRRYITVEEDQYLILNDCYLIENE"
BASE COUNT          665 a          171 c          270 g          504 t
ORIGIN      
        1 atatacttaa tataatttgc aattttacat aagtttgtta agtacataac taatttaaga
       61 atatgtattt atatattaaa aatttattat gagggggaca attttattat gaaattctat
      121 aaaagaatat taacattgac tttaagtatt tcttttgtat ttgcaaatat tcaattagta
      181 gatgcaatat catctgtaga aaaaatacaa ggaaaaaata agtatgaaat agcaggtaaa
      241 atagcagata aaaatgcata taaaactgca tataaaactg catataaaac tgcatataaa
      301 actgctatat taattaatac tagtaactct attgcagatg gattaagtgc aagtggacta
      361 gcaggagctt taaatgcccc tatactatta actgaaaaaa atactatacc aactgagaca
      421 tctgcaagat taaaaaatgt atcaaaagtt tatataattg gaggaacata ttctattagt
      481 acatctgtcg aaaattcatt aaaatctaag aaaatgaaag ttgtaagaat taagggaaat
      541 gacagaataa aaacaagtta taatgttgca aaagaaataa attcaataaa aaaagtcaat
      601 actgttatgc taaccaatgc atataaagga gaagcagatg ctataagtat tgcatctgta
      661 gcagcaagag ataaagcacc aataattctt actaatggac aaagtatacc tttttcaact
      721 agtggtttaa agtcttatgt aataggagga acagcttcaa tgagtaccac tttagtaaac
      781 aatactaaat ctactagact aggggggagt actcgttttg aaactaataa agcaataata
      841 aataagtttt ataaggatgc tagagagttt tatatagctg gagcttatga attaacaaat
      901 gcacttgtag gatcttcttt atcaaaacat ggtccaatgg ttttagttaa cgatggtagc
      961 aataaaagca ttttaaaaaa tgctaagaag ataacttcta taggatatat agattcaaat
     1021 atagtacaac agtgtttaaa tataacaaat ggaattggag atattaatac tggggttgta
     1081 aaaaatgtta aacctactac aaagactata aaagatggaa tgtataaggt tggaaaagat
     1141 atctcagcag gtgaatactt aataacttca aactcaggaa gttatgcttc ttattatgaa
     1201 gttacaagtg atagtacagg taatgctgat agtatacttt caaatgatat ttttagtggg
     1261 actagatata tcaccttaaa gaatggtcaa tatattaaaa ttgaggattc aacaatgaca
     1321 ttagcaaagt atgctaaagc ccagaaggcc aagaatggta agtttggaaa tggtatgtat
     1381 aaaattggat tagaaattcc tgctggagaa tatattataa tgtcaaattc ttctgatgca
     1441 tattatgaag ttagaaatga tagcttaggt aatgcagagg gaatagttac taatgatact
     1501 ttttcaggaa gaagatatat aacggttgag gaagatcaat atttaatatt aaatgattgt
     1561 tatttaattg aaaatgaata gatgtaattg tatttaatag taaatcatat
//
LOCUS       DAEQCW010000239         1586 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.240, whole genome shotgun sequence.
ACCESSION   DAEQCW010000239 DAEQCW010000000
VERSION     DAEQCW010000239.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1586)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.240"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            441..593
                     /locus_tag="KRO40_003621"
     CDS             441..593
                     /locus_tag="KRO40_003621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094413.1"
                     /translation="MKNLNKNTILGEVIITIAACDDEKEIQIVIKNQVDNILKNKNKE
                     YRIKKI"
     gene            910..1155
                     /locus_tag="KRO40_003622"
     CDS             910..1155
                     /locus_tag="KRO40_003622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="HBH2094414.1"
                     /translation="MLIHTKNKTFDAICILEKIEKDLNIEELVRCHKSYIINLNYVEN
                     IKSNTAILDSQEEVPISRYRYKDIKERFLKFIGDRIC"
     gene            1149..1421
                     /locus_tag="KRO40_003623"
     CDS             1149..1421
                     /locus_tag="KRO40_003623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094415.1"
                     /translation="MLNHINKILLILSLFTPIMILKSILTYDKDTDKTKKISFFTVLL
                     AYLITKIIILFNVDKTHDYNMKKNLYDIIYYLIFITWELTIIIFIR"
BASE COUNT          737 a          180 c          172 g          497 t
ORIGIN      
        1 aagataatat atttaaaaat tagagaataa gaatgtacat acttgaatct cataaatgta
       61 tataaagata tgtatgaata aaaatagcag ctacttagaa tagttacact atttaagatt
      121 tattatatta tagattgact aaacaataga tatttattaa tgactcaatt tataaacttt
      181 aaaagttata ccccaataat accccaacca caaaaataaa caataaaaaa taaccaaaaa
      241 aatcagtcta atatcataac taaatagcta tatacctaca ttcacaaaaa ccaacaaaac
      301 aatcaaataa ccacttatag actcccctcg tatccaccat tgaaatccac gaatacctat
      361 atccaattgg atataggtat ttttatacat ttttaattta aatattattg ataaatacat
      421 ttaaaaagtg ttaacctaaa gtgaagaatc taaataaaaa tacaatacta ggagaggtca
      481 tcattacaat agcagcttgt gatgatgaaa aagaaataca aatcgtaata aaaaatcaag
      541 ttgataatat attaaaaaat aaaaacaaag aatatcgaat taaaaaaata tagctcaaaa
      601 gaagaaccat tacaaagtta attgagagga tacactactc ttagatataa aaatgccaga
      661 actaaatagt atagatatcg caagaaacat aagaaaagta gataataata tttataacat
      721 ctctaataaa ttatgtacag gaaagatatg aagtaagagc ttattgatac ttattaaagc
      781 caataaattt tcaagaacta gaaaaacaca tattaacatg tatcaaaaaa attgaaaaaa
      841 ataaaaataa gtctaacaca tacaaaatct actctagcaa aaaaatagat agaagttcaa
      901 aaaaagaaca tgctaataca tacaaaaaat aaaacttttg atgctatatg tatactagaa
      961 aaaatagaaa aagatttaaa tatagaggaa cttgtaagat gtcataaaag ttatataatt
     1021 aacttaaact atgtagaaaa tataaagtca aatactgcaa tattagacag tcaagaagaa
     1081 gtacctatta gcagatatag atataaagat ataaaagaga ggtttctaaa atttattggt
     1141 gatagaatat gctaaaccat ataaataaaa tattattaat attatcattg tttacaccaa
     1201 taatgatact aaaaagtata ttaacttacg ataaagatac agataagact aagaaaatat
     1261 ctttttttac tgtattatta gcttatctta taactaaaat cattatatta tttaacgttg
     1321 ataagaccca tgattataat atgaagaaaa atctatatga tataatctat tatttgatat
     1381 ttattacttg ggaacttact ataattattt ttataagata ggaattgtta aatatatagt
     1441 ttcatttttc ttatttgacg tatatcaccc tttaataaaa gatgttatat ctataaattt
     1501 attttttgta gttacaagta atgtaatatc atcagaggaa gctctattag tgtttagtta
     1561 tgataatgct aaagtagata tatact
//
LOCUS       DAEQCW010000240         1454 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.241, whole genome shotgun sequence.
ACCESSION   DAEQCW010000240 DAEQCW010000000
VERSION     DAEQCW010000240.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1454)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.241"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            98..343
                     /locus_tag="KRO40_003624"
     CDS             98..343
                     /locus_tag="KRO40_003624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pathogenicity locus"
                     /protein_id="HBH2094416.1"
                     /translation="MGELQKIPGVGKATEKSLIMLGYTTIKLLKDANPAQMYEKECLM
                     RGQHIDRCQLYVYRCAVYFASTENPEPEKLKWWYWKD"
     gene            complement(561..830)
                     /locus_tag="KRO40_003625"
     CDS             complement(561..830)
                     /locus_tag="KRO40_003625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBH2094417.1"
                     /translation="MFESRCGVCCDSCTKKEQVNCTGCPTMEKPFWGGECKVKTCCES
                     KELNHCGECDTFPCDMLLNKGKDQGFDPMVNIEQCRKWLEETVSN"
BASE COUNT          585 a          211 c          159 g          499 t
ORIGIN      
        1 atataataaa aaattaaata ttaaatatta actataataa aaaaatatct ggtaataggt
       61 ataatataaa aagaatatac cagaaagaag gtgaagtatg ggagaactac aaaaaattcc
      121 aggggtaggg aaagcaacag aaaaatcttt aatcatgtta ggatatacaa ctattaaatt
      181 acttaaagat gcaaacccag cacaaatgta tgaaaaggaa tgtttaatgc gtggacagca
      241 catagacaga tgtcagttat atgtatacag atgtgcagta tattttgcat caactgaaaa
      301 tccagaacca gaaaaattaa agtggtggta ttggaaagat taaaaaatca aaaaagttag
      361 acataaaaaa gagttgaata tccgttttaa ataataaaaa ctaatactca actctttttt
      421 agtcgtaaat tttatgtaaa tctatttgta tggctaaata tacccatcaa taaatgtata
      481 aatataccaa tcaacaaatg actaaacata ctacctaaca aaggattaaa taaattactt
      541 aacaaagcat tctaaaacaa ttaattagaa actgtttctt caagccattt tctacattgc
      601 tcaatattta ccatagggtc aaaaccttgg tcttttccct tatttaaaag catatcacaa
      661 gggaaagtat cacattcacc acaatgatta agttccttac tttcacagca agttttaacc
      721 ttacattctc caccccaaaa tggtttttcc atagttgggc aaccagtgca atttacttgt
      781 tctttttttg tacaactgtc acaacagaca ccacatcttg attcaaacat gttcaaacat
      841 cctttccatt atttaaaaat attataaaat gattttagat gaatacaaaa gtgcaaatag
      901 ttgattttag gtcatctaaa tgttaaacat aaaattatta gtactggtaa atttataaaa
      961 actattccaa aaatcttttt gaatatttca aaacacaata aattacttca aatccctttg
     1021 aatatatttt acagcattat agattgcttt aaatctcttt gaatattcta caagactata
     1081 gattagttta aatccctttg aatatatttt acaacattat agattgtttt aaatctcttt
     1141 gaatattcta caagactata gattagttta aatccctttg aatatttcaa aacaccatag
     1201 attactttaa atccctttga atattctata acactataaa ttacttttaa cttttatata
     1261 accataaagt ttttatctgg cactttaaat ggagttttat atcaaatttg ccttccatcg
     1321 aataaccaaa cttaatttaa ttacacattc caagagtcaa atattcattc aatatatttg
     1381 ataattctat gttatagcta taattaaata tagattatta aagttaaata tttatttaat
     1441 atattgaatg attt
//
LOCUS       DAEQCW010000241         1418 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.242, whole genome shotgun sequence.
ACCESSION   DAEQCW010000241 DAEQCW010000000
VERSION     DAEQCW010000241.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1418)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.242"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(207..1145)
                     /gene="pdaA"
                     /locus_tag="KRO40_003626"
     CDS             complement(207..1145)
                     /gene="pdaA"
                     /locus_tag="KRO40_003626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBH2094418.1"
                     /translation="MFRKVLHYLTLLSISIFFIVGCSNSQNNQNENQNKETQLQEDKE
                     KIDSGKDTSNVIVSDGTDKPSKATTNNDDNKLDVSSLDNTTLDWFYIPNNKHKTPEVN
                     TDIEFKFSDYDALYNGPTKDGQKTLYLTFDEGYENGYTTKILDTLKQNQVKAVFFVTT
                     PYIKENKDLVKRMVSEGHIVGNHSKTHPSMPTKTSNLKNFNDELYDVEKLYKDVTGKD
                     MVKFFRPPMGKYSEKSLAMTKNLGYKTVFWSFAYRDWDTDKQPSHEEATQKIMDNLHD
                     GSILLLHAVSKTSTEILNDFISNARKLGYEFELLEY"
BASE COUNT          479 a          193 c          175 g          571 t
ORIGIN      
        1 tataacatct aaaatactgt tatctatatt taatatcttg ccaaattttt tgatgtttta
       61 ttgtcctgtc ccaccaacat atataagcta tcacaagttt ttacctatac tatcaccaaa
      121 caaaaattct aattttaatt tattatttta taacctatat tatattaact atattagttt
      181 gtagacttta gatgtaatta taaatattaa tactccaaga gttcaaattc atatcctagt
      241 tttcttgcat ttgatataaa atcatttaaa atttctgtac tagttttgga aactgcatgt
      301 agtaacaaga tagaaccatc atgtagatta tccattattt tttgcgttgc ttcttcatgt
      361 gatggttgtt tatcagtatc ccagtctctg tatgcaaaac tccaaaatac agtcttgtat
      421 cctaaatttt tagtcattgc caagcttttt tctgagtatt ttcccatagg aggtctaaaa
      481 aatttaacca tatctttccc agttacatct ttatataact tttcaacatc atataattcg
      541 tcattaaagt tttttagatt gcttgttttt gttggcatag atggatgggt tttactatga
      601 tttccaacta tatgtccctc agaaaccatt ctttttacta aatctttatt ttcttttata
      661 tatggagttg taacaaaaaa aactgcttta acctggtttt gttttagagt gtcgagtatc
      721 tttgtagtgt atccattttc ataaccttca tcaaatgtaa gatatagtgt tttttgacca
      781 tcttttgtag gtccattgta tagggcatca tagtcagaaa atttaaattc aatgtccgta
      841 tttacttctg gtgttttatg cttattgttt ggtatataaa accaatcaag agtagtgtta
      901 tctaaagaag atacatctaa tttattatca tcattattag tagtggcttt tgatggttta
      961 tctgttccgt ctgaaactat tacattggaa gtatctttac cactatctat tttttcctta
     1021 tcttcttgta actgtgtttc cttattttga ttttcgtttt gattgttttg tgaatttgaa
     1081 catccaacaa taaaaaaaat agaaatagaa agtagtgtta aataatgcaa tacttttcta
     1141 aacattttga agctcctttc taaattaata ataattgcat ataataataa ttatatgatt
     1201 aattacaatt gcatatagta ttattataat tggaaattac tattaataat agttatatct
     1261 ttaaaaataa agtcacaata gtatgacaaa gggtgaataa tcaataaatt taaaaaaaaa
     1321 tgaaaaaaat agttgaccat attatgagaa gatgttatta taataaatgt gctcaacaag
     1381 aagtaacaaa ataacaagca caaagaagtt aattgaat
//
LOCUS       DAEQCW010000242         1378 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.243, whole genome shotgun sequence.
ACCESSION   DAEQCW010000242 DAEQCW010000000
VERSION     DAEQCW010000242.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1378)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.243"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            912..1301
                     /locus_tag="KRO40_003627"
     CDS             912..1301
                     /locus_tag="KRO40_003627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2094419.1"
                     /translation="MTIKKLPQSELKIMKFIWKSDSKVTSRDIVLGMEQKYQWKQTTT
                     LTLLSRLVVKRFLNSQKIDKYTHYEVLIKEKEYIGVETRDFFRNIHDSSIKSLLLSLH
                     ENINLSKDDILLIEEWIKNLKEEEKDV"
BASE COUNT          597 a           86 c          253 g          442 t
ORIGIN      
        1 taatatataa ataaaaaaac tctaaaatag aaggatataa ttatatagaa tgtttcaatt
       61 aaacaaggta aaaactataa tcttaaaatt aaaattaaca ttattcttaa gaagcaagaa
      121 atttagaaag taggaagttt agtgataagt ggtagtaagt aagaaattta ggaagtggga
      181 agtttagtga taagtggtag taagtaagaa atttaggaag tgggaagttt agttataagt
      241 ggtagtaagt aagaaattta ggaagtggga agtttagtta taagtagtag taagtaagaa
      301 acttaggaag tgggaagttt attagtaata atttatagca agtaagaaat ttagtaataa
      361 tttgtagcaa gtaagaaatt tagaaagtag gaagtttagt aataatttat agcaagtaag
      421 aaatttaggg agtaggaagt ttagtaataa tttgtggtaa gtaagaaatt tagaaagtag
      481 gaagtttagt aataatttat agtaagtaag aaatttagta agtgagaagt tcagtaataa
      541 gttgtagtaa ataaaaagtt taggaagtag gaagttcagt aataagttgt agtaaataaa
      601 aaatttagga agtaggattt actgaaatac aaatatttaa aatcaaagag tttaaaagaa
      661 aggagagcta ctggacaagt atccaaaata gatagctgag tacaaaatat ttcataaaat
      721 taagcaatat aatacaagag aattttgaca ttatttatat atatttaccg tgtacaaata
      781 gctaaattta ggattaagat tgaaaaatat cttataagtc tgagcttata taaatccgta
      841 taagatgtat ttaatcgaaa aattttatta tggatattgc ttgtctatat tctgagtagc
      901 aaggttttat catgactata aaaaagttgc cacaatcaga attaaagata atgaaattta
      961 tatggaaatc agattccaaa gtaacatcta gagatattgt tttaggaatg gagcaaaaat
     1021 atcaatggaa acaaacgaca actttgactc ttttatctag attagtagta aaaagatttc
     1081 taaattctca aaagatagat aaatatacgc attatgaagt tttaattaaa gaaaaggaat
     1141 acataggagt tgagacaaga gattttttta gaaatattca tgattcttct ataaaaagtt
     1201 tattgttgtc attacatgaa aatattaatt tgagcaaaga tgatatttta cttattgaag
     1261 agtggataaa aaatctaaaa gaagaggaga aagacgtata agcaaacgta tttcttatag
     1321 catcaatata aagtgtatgt aagtgtattt atgtaatata ttagtctact taagtaat
//
LOCUS       DAEQCW010000243         1363 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.244, whole genome shotgun sequence.
ACCESSION   DAEQCW010000243 DAEQCW010000000
VERSION     DAEQCW010000243.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1363)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.244"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(206..517)
                     /locus_tag="KRO40_003628"
     CDS             complement(206..517)
                     /locus_tag="KRO40_003628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094420.1"
                     /translation="MKKIIKSFTFWFFLIALFEIYMHQIGQDSKSIVLIGLNPILSII
                     SRVDSFFVFMDSGMQIPCRTITGSISIYWYIASILSFLIYGIILDLIRIVISKIGNKT
                     K"
     gene            complement(573..1166)
                     /locus_tag="KRO40_003629"
     CDS             complement(573..1166)
                     /locus_tag="KRO40_003629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBH2094421.1"
                     /translation="MISDSISKRRSIRKYKNQSISHETIEKIIEAGINAPSSKNRQPW
                     RFVVITEKEKESMLKAMSKGIQNEINDNGLLPGSRQHIAGANYTVEIMKQAPVTIFIL
                     NILGKSPLEKLSPEERFYEMANMQSIGAAIQNMSLTAVELGLGSLWICDVYFAYRELC
                     EWLNTDSQLVAAISLGYPDEEPSRRPRLQLSDVTEWR"
BASE COUNT          485 a          196 c          173 g          509 t
ORIGIN      
        1 ataaactaat ttaagaaata tagaaaatta atttaaagaa atacaataca ttaattttta
       61 agtaacatta aattaatgta agtaaaataa tgttcatatg aagatttaaa ggtgcatttt
      121 ctgaagctaa gtatatgttg tagagtgtta ggtctctcta tcctgtgaag tttaatagct
      181 caagaaaatg cactatttat gatgattatt ttgttttatt tccaattttg gaaataacta
      241 ttctaattaa atctaaaatt ataccataaa taagaaaaga aagtatagat gctatgtacc
      301 aataaatcga aattgaccct gtaattgttc tacatgggat ttgcatacct gaatccataa
      361 aaacaaaaaa actatcaact ctggaaataa tagacaaaat aggatttaaa cctattagaa
      421 caatactttt tgagtcttga ccaatttgat gcatataaat ctcaaataat gcaattaaaa
      481 aaaaccaaaa tgtaaaagat ttaataattt ttttcatcaa aatacctcac ataatataaa
      541 ttctgtttgc actatttgct tactacaact atttatctcc attcagtcac atcacttaat
      601 tgtaatctag gtcttcttga tggttcttca tcaggataac ccaaagatat tgctgccact
      661 aattgactat ctgtatttaa ccattcacat aattcacgat atgcaaagta tacatcacaa
      721 atccaaagac tacctagacc taattccaca gctgtaagcg acatattctg aattgcagct
      781 ccaattgatt gcatgtttgc catttcatag aatcgttctt caggggatag cttttctaaa
      841 ggtgatttac ctaatatatt taaaataaaa attgttactg gagcttgttt catgatttca
      901 actgtgtaat ttgcaccagc gatatgttga cgacttcctg gaagaagccc attatcatta
      961 atttcatttt gaataccttt gctcatggct ttaagcatag attctttttc cttttcagtg
     1021 atgacaacaa aacgccatgg ttgcctgttt ttagatgaag gtgcatttat tccagcttca
     1081 attattttct ctatagtttc atgtgaaatg ctttgatttt tatattttct gatacttcgt
     1141 ctttttgata tagaatcact tatcatttta agtaacctcc gtttattttt tggaaaaatc
     1201 tatttaattt ttattttcta ttttaattat tttagcatta atcagaaaaa aagtcattga
     1261 ttttagtata caattattaa tgattatatt aagaattgta tcaaaaagta tgtgattata
     1321 ctaagggatt atattaaaca ttatatttaa aattgtatga aag
//
LOCUS       DAEQCW010000244         1335 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.246, whole genome shotgun sequence.
ACCESSION   DAEQCW010000244 DAEQCW010000000
VERSION     DAEQCW010000244.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1335)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.246"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            77..1294
                     /locus_tag="KRO40_003630"
     CDS             77..1294
                     /locus_tag="KRO40_003630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallo-hydrolase"
                     /protein_id="HBH2094422.1"
                     /translation="MLGKKCMDYLQTLGKISSTTNGLTRLILTQEHKKSIDLISSWME
                     GLNLDIEIDDIGNVIGTYKSSFPNAPTLVVASHQDSVKCGGIFDGMLGIIVPLVGLEE
                     AKHNNRSYPFNIKLIAFAEEEGTRFETSLMGSKVFAGTFKEELLKSVDENGITLEEAV
                     TKFGFNTKNLTNLHPRKDVDAYLEFHIEQGPVLENESLPAGIVSSITGFKSFKISVNG
                     KSGHAGTLPMNMRLDAGCCACECVLAIEKVAKTTTDLVATVGKMNFYPSSSNVVPERA
                     EFTLDVRSCSQEILDNSVEKIFNEISHICENRKLNYTSELAFENVPVPCSNKITKIIE
                     KSFIDLNLNPFYIYSGAGHDAQEMDNITDIGMVFIRCAGGVSHNPNESVSVDDLDTAV
                     KIFLKILDNLDLK"
BASE COUNT          493 a          156 c          236 g          450 t
ORIGIN      
        1 tatttgaaag ttcaaaaatt ataagtataa aagctaatct tagcttaaat aaaaattata
       61 tttttaggag gtaaatatgt taggaaaaaa atgtatggat tatctacaaa cattaggaaa
      121 aataagttca acaacaaatg gtcttacaag acttatcttg actcaagaac ataaaaaatc
      181 tattgattta attagttcat ggatggaagg tttaaatctt gatattgaaa ttgatgacat
      241 tggaaacgtt ataggtacat ataaatcaag ctttccaaat gctcccacat tagtagttgc
      301 atctcatcaa gatagtgtaa agtgtggagg tatatttgat ggtatgttag gtataatagt
      361 gcctctagtt ggtcttgaag aagcaaaaca caataatagg tcttatcctt tcaatattaa
      421 gctaattgct ttcgctgaag aggaaggaac tagatttgaa acttctttaa tgggaagtaa
      481 agtttttgct ggtactttta aagaggaact tcttaaatct gttgatgaaa atggaattac
      541 acttgaagaa gctgtaacaa agtttggatt taatacaaaa aacttaacaa atttgcatcc
      601 tagaaaagat gtagatgcat atttagaatt tcatatcgag cagggtcctg ttttagaaaa
      661 tgaatctctt cctgctggaa ttgtatcaag tattacagga tttaaaagtt ttaagatatc
      721 agtaaatggt aagtctggac atgctggtac acttccaatg aatatgagac ttgatgctgg
      781 atgttgtgcc tgtgaatgtg tattagctat cgaaaaagta gctaaaacga ctactgattt
      841 ggttgctact gtaggaaaga tgaatttcta tccatcttca tcaaatgtgg tacctgaaag
      901 agctgaattt actcttgatg tacgctcttg ttcacaagaa attcttgata attctgtaga
      961 aaagatattt aatgaaatat cacatatatg tgaaaataga aaacttaatt atacaagtga
     1021 acttgctttt gaaaatgttc ctgtaccatg ttctaataaa ataacaaaaa tcatagaaaa
     1081 aagttttata gatttaaatc ttaatccttt ttatatttat agtggtgctg gccatgatgc
     1141 tcaggaaatg gataatataa ctgatattgg tatggtattt ataagatgcg ctgggggcgt
     1201 aagtcataat cctaatgaaa gtgtttctgt agatgacttg gatactgctg taaaaatatt
     1261 tttaaaaata ctagataatc ttgatttaaa ataattctta tataagaaag tatattaaaa
     1321 tatataatct aaaaa
//
LOCUS       DAEQCW010000245         1306 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.247, whole genome shotgun sequence.
ACCESSION   DAEQCW010000245 DAEQCW010000000
VERSION     DAEQCW010000245.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1306)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.247"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            159..890
                     /locus_tag="KRO40_003631"
     CDS             159..890
                     /locus_tag="KRO40_003631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094423.1"
                     /translation="MLSKKNVSLIILVIILSLLTAIFIFNNKNTNNKLKEVTKNNEEI
                     VPKNLEGLSIEQLIEIRDKAIDKNLEGLREFGEDSVKKRKDSILNFEFGLVAFVNKNY
                     SNLTEKEKLIRQINIVNYENSINDIMDPSGSFFELANQNYQVNEFLLKNGKDYKEWSY
                     EGLDFLIDHLEELCKFVDFDVKDVIDIIDPTIKTDLSEEQKKSLNDKLKKISSSDTLS
                     EEVKKEIKNWENNLNNLNMNKNNSN"
     gene            complement(1047..1253)
                     /locus_tag="KRO40_003632"
     CDS             complement(1047..1253)
                     /locus_tag="KRO40_003632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094424.1"
                     /translation="MSKYSSLWEYVKKNNSQSFKLTFEEIKDIAGIEIDHSFLKYKKE
                     LNEYGYQVGKISLKEKTVIFDKIG"
BASE COUNT          554 a          137 c          153 g          462 t
ORIGIN      
        1 atattaaata tctaataaga aaatttaata agaaaaatat agattatatc aaaaaaatat
       61 tctattataa tctttagaac aaacagtagt aaatgttatc ttcataaaca aatttatttt
      121 tcacaagtac aatacttatt taaaaaagga ggtttaatat gttaagtaaa aaaaatgtaa
      181 gtttaattat tttagtaata attttaagtt tattaactgc tatatttatt ttcaataata
      241 aaaatactaa caataaattg aaagaagtta ctaagaataa tgaagaaata gtacctaaaa
      301 acttagaagg tttaagtata gaacaattaa tagagattag agataaagcc attgataaaa
      361 atttagaagg tcttagggaa tttggagaag attcagtaaa aaaacgtaaa gattcaattt
      421 taaactttga atttggatta gtagcttttg ttaacaagaa ttatagcaac ttaacagaaa
      481 aagagaaatt aataagacaa attaatattg ttaactatga aaactctata aatgatataa
      541 tggatccttc aggttcattc tttgaattag caaatcagaa ttaccaagtg aatgagtttc
      601 tattaaaaaa cggaaaagat tataaagaat ggtcatatga aggtctagat tttctaattg
      661 atcatctaga agaactgtgc aaatttgttg attttgatgt aaaagatgta atagatatta
      721 ttgatcctac aataaaaaca gacctttcag aggaacaaaa gaaatctttg aatgataaat
      781 taaagaaaat atcttcaagt gatactttaa gtgaagaagt taaaaaggag ataaaaaact
      841 gggaaaacaa tttaaataat ttaaatatga ataaaaataa ttctaattaa ttttctcata
      901 agaaaaatgc ttatatcgtg ataatgtgaa atgtacataa ttataaacaa aaaaggggct
      961 gtgacactaa aaaatagtgc tacgcccttt tttatttgta ataatcatca atacaaatta
     1021 ttttattata tgtaattatt tatgtcttaa ccaattttat cgaaaataac agtcttctct
     1081 tttaaagaga tttttcctac ttgatatcca tattcattta attccttttt atatttcaaa
     1141 aacgaatggt ctatctctat cccagcaata tcttttattt cttcaaaagt taatttaaac
     1201 gattgactat tgtttttctt aacatattcc cataaagaac tatatttact catcttatat
     1261 cactcctttt aaaatcatat cttatctatt aatttatatt ctatca
//
LOCUS       DAEQCW010000246         1269 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.248, whole genome shotgun sequence.
ACCESSION   DAEQCW010000246 DAEQCW010000000
VERSION     DAEQCW010000246.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1269)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.248"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..414
                     /locus_tag="KRO40_003633"
     CDS             <1..414
                     /locus_tag="KRO40_003633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /protein_id="HBH2094425.1"
                     /translation="ADCYYKSAKAGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKN
                     YSSAFVSAPDWVSAKGMRILGNPLRGDEKVISGESGAVTTGALVSILESEDLKDLREA
                     LKLDENSKVLLISTEGDTDPDKYRDIVWNGECQSK"
     gene            679..>1269
                     /locus_tag="KRO40_003634"
     CDS             679..>1269
                     /locus_tag="KRO40_003634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2094426.1"
                     /translation="MLNETRKKQLTEVCQDLIRNASYSGQEENVVKAIEENFALLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEARIVDGKIYGRG
                     TSDMKGQVSAMMAAVSYFAEDTNKDFEGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKG"
BASE COUNT          550 a          134 c          255 g          330 t
ORIGIN      
        1 gctgattgtt actataaatc agcaaaagct ggagatggaa aaccaagatt tgttggagga
       61 gatatgccaa ctataatggc agggcttgct tgtggagaac caaacactat aggttttgaa
      121 gtgttaaaaa attattcatc agcattcgtt tcagcaccag actgggtatc tgctaaaggt
      181 atgagaatat taggaaaccc tctaagagga gatgagaaag taatctctgg agaatctgga
      241 gcagttacaa ctggagcatt agtttcaatc cttgaaagtg aagatttaaa agacttaaga
      301 gaagctttga aactagatga gaactctaaa gtattattaa taagtacaga aggagatact
      361 gaccctgata aatatagaga tatagtttgg aatggtgaat gccaaagtaa ataaaagact
      421 taaggaaaag aaaaacttaa taaataaatg aaaaagtaaa gcaaataaaa aagtaaagca
      481 aatgaaaaat tcaaaataaa aactaaataa aattaaataa aaccaaataa aattaaaata
      541 aagtctaaat aaaaatttaa taaataaaat ataaagaaat aaaaaatcaa tagattaagt
      601 gaaatgctaa taaattaaaa aagtgaaata tcaaaataaa acgtcaacaa attaaaaatt
      661 atatggggga atatcaaaat gttaaatgaa acaagaaaaa aacaattaac tgaagtatgc
      721 caagacttaa taagaaatgc tagttattca ggtcaagaag aaaacgtagt aaaagctata
      781 gaagaaaatt ttgctttact aggttttgat agttggtcaa gagatagata tggaaatata
      841 gtaggatgta taaaaggaaa taaaccaggt aaaaaaatat tatttgacgg acatatagat
      901 acagttccag ttccagatgc aagtaaatgg agtgttcctc cttttgaagc gagaatagta
      961 gatgggaaaa tatatggtag aggaacttct gatatgaagg ggcaagtaag tgctatgatg
     1021 gctgctgttt catactttgc agaagatact aacaaagact ttgaaggtga attgtatgta
     1081 gcaggtgttg ttcatgaaga aatatttgaa ggtgtttcag ctagagagat aagtaaggct
     1141 gttcaacctg attatgttgt aataggtgaa tcttcagaat taaacctaaa gataggtcaa
     1201 agaggtagag gagaaatagt agtagaaact tttggtaaac cagctcactc tgctaatcca
     1261 gaaaaaggt
//
LOCUS       DAEQCW010000247         1179 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.249, whole genome shotgun sequence.
ACCESSION   DAEQCW010000247 DAEQCW010000000
VERSION     DAEQCW010000247.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1179)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1179)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.249"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            354..728
                     /locus_tag="KRO40_003635"
     CDS             354..728
                     /locus_tag="KRO40_003635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBH2094427.1"
                     /translation="MKEEILIEKLLRAELIVMEYLWKKDTLMPKKEIVKEIKQIYGWH
                     KSTIKILLKRLVAKRYLARYIINSQSHYKIIDSKEYYTFKKKVLKSSKSIKIMRSLTT
                     THKNVSKEKLDLLDEYYRNLKE"
     gene            833..1179
                     /locus_tag="KRO40_003636"
                     /pseudo
     CDS             833..1179
                     /locus_tag="KRO40_003636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430377.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
BASE COUNT          530 a          109 c          160 g          380 t
ORIGIN      
        1 ttattacata cctaaaaaac tttcataaaa ataaaaataa aatatgattt tagtaacttg
       61 ttaacataac ttataattta ttttataagc attagcctat atagctttgt gctactaaat
      121 ttctttgatt ctaacgattt agtgctattc tacaactaaa ataatacaat agagctattt
      181 attgtttggt agcattgttt gcaaattaaa caaatttata tatatgaata ttattttacg
      241 ttcaaaaaaa cagactaaat atgtagaata ttcggtaaaa cttacctcta gtttttgtct
      301 taaaaagctc ctattattaa cttaagttag aagaattaag gaagtgacat aaattgaaag
      361 aagaaatatt aatagaaaaa ttattaagag cagaattaat agtaatggag tatttatgga
      421 aaaaagacac tctaatgcct aaaaaagaaa ttgtaaaaga aataaaacag atttatggat
      481 ggcataaaag tacaataaaa atactactaa aaaggctagt tgctaaaagg tatttggcta
      541 gatatattat aaattctcaa tctcattata aaataataga tagtaaagaa tattatactt
      601 ttaagaaaaa ggtactaaaa tctagtaaaa gcataaaaat aatgcgttca cttaccacta
      661 cacataaaaa tgtaagtaaa gagaagttag acctattaga tgagtattat agaaacttaa
      721 aagaatgata tagtaaaaat cgaatgtaat tatttacctt aattcttttg tttgtaaaac
      781 tttattgata cataatttaa catatacata aattggtaaa ggaatgtata ctatgaaaat
      841 tagtaaatta ccagaagcgg aattaaaagt tatgagatat atttgggaat cagaaaaggt
      901 attaatatca agagaaatca ccaagtctat ggaacaaaaa tatgaatgga aagatacaac
      961 tatatttaca gtattaaaaa gattactaaa gaagagagtt tttagaaacg gagaaaatag
     1021 ataagtgtac acactataat gtattagtaa aaaaaaataa tatcagagat tttaaacaaa
     1081 agaattttta aagaatacac ataaaaattc aatattaagt ttaatgtcag cactatgtag
     1141 taaggatgat gaagtagatg gtgatatttt aaatttatt
//
LOCUS       DAEQCW010000248         1159 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.250, whole genome shotgun sequence.
ACCESSION   DAEQCW010000248 DAEQCW010000000
VERSION     DAEQCW010000248.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1159)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.250"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            35..205
                     /locus_tag="KRO40_003637"
     CDS             35..205
                     /locus_tag="KRO40_003637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094428.1"
                     /translation="MDSNNNTIKSTVKKGISFGSCLAMIISYTAWKSIPWAIFHGLMS
                     WIYVLYYWVKYA"
     gene            578..>1159
                     /locus_tag="KRO40_003638"
     CDS             578..>1159
                     /locus_tag="KRO40_003638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HBH2094429.1"
                     /translation="MKEKLEEKSKIIKTSKEYKRTIIEEKDREWTKKLNDILSRGDFS
                     NEKLDKIKDLIPKEILTSENVGEVVTEDGYAKPEYDEVFKSLFTLNNDYDLLANFIND
                     ILKDAPYANRNIKQFTQIKRIIKVETDPTINYIGEKRPRLDILAEDEERNHINIEMQR
                     ALEEDYLERAEYYLSRVHGRKLEEGKEYKEIGKT"
BASE COUNT          462 a          112 c          194 g          391 t
ORIGIN      
        1 taacttgttt attttgaatt ttggaggatt aattatggat tcaaataata atactataaa
       61 atcaactgtt aaaaagggta tttcttttgg ttcttgttta gcaatgatta tttcttatac
      121 tgcatggaaa tctattccat gggctatttt tcatggctta atgagttgga tatatgtact
      181 ttattattgg gttaagtatg catagattaa attaataaat aagtatgtaa tattgtaaag
      241 tttaagaaac aaaatgtaag ggagtgtctc gaagtgaact tttagtttat aaggcactct
      301 tttttgtatt aaataaaata tattttcatt atttaaacaa tgaaaaagat gagtatctct
      361 attttaatac atacccttat attcattcat ttatcaacaa tagttttaaa aagaaagcta
      421 tctaaaatct attgtaatct aagtgcttct ctttaaagtc ttaactttag taatgatata
      481 taagtttata aggttcttat ttcaataatg caaattttac ttagaagttc agactttggt
      541 atgaagaaat gggtaataat aaaaaagagg tgttgatatg aaagaaaaat tagaagaaaa
      601 atctaagatt attaaaacat caaaagagta taaacgaact ataattgaag aaaaggacag
      661 agaatggacc aaaaaattaa atgacatact tagtagaggt gatttttcta atgaaaaatt
      721 agataaaatc aaggatttaa ttccaaaaga aatattgact agtgaaaatg ttggagaagt
      781 tgtaactgaa gatgggtatg ctaagcctga gtatgatgag gtatttaaat cattgtttac
      841 tttaaataat gattacgatt tacttgcaaa ttttataaat gatatcctca aagatgctcc
      901 atatgccaat aggaatatca aacagttcac tcaaataaaa agaataatta aggttgaaac
      961 cgacccaaca attaattaca ttggtgagaa aagacctaga cttgatattt tggctgaaga
     1021 tgaagaacgt aaccatataa atattgagat gcaaagagct cttgaagagg attatttgga
     1081 aagagctgaa tattatctta gtcgtgtaca tggtagaaag ttagaagaag gtaaagaata
     1141 taaagaaatt ggaaaaact
//
LOCUS       DAEQCW010000249         1146 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.251, whole genome shotgun sequence.
ACCESSION   DAEQCW010000249 DAEQCW010000000
VERSION     DAEQCW010000249.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1146)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.251"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..989
                     /locus_tag="KRO40_003639"
     CDS             <1..989
                     /locus_tag="KRO40_003639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_105161403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="peptidase C80"
                     /protein_id="HBH2094430.1"
                     /translation="NTFIASTGYTSINGKHFYFNTDGIMQIGVFKGPNGFEYFAPANT
                     DANNIEGQAILYQNKFLTLNGKKYYFGSDSKAVTGLRTIDGKKYYFNTNTAVAVTGWQ
                     TINGKKYYFNTNTSIASTGYTIISGKHFYFNTDGIMQIGVFKGPDGFEYFAPANTDAN
                     NIEGQAIRYQNRFLYLHDNIYYFGNNSKAATGWVTIDGNRYYFEPNTAMGANGYKTID
                     NKNFYFRNGLPQIGVFKGSNGFEYFAPANTDANNIEGQAIRYQNRFLHLLGKIYYFGN
                     NSKAVTGWQTINGKVYYFMPDTAMAAAGGLFEIDGVIYFFGVDGVKAPGIYG"
BASE COUNT          395 a          146 c          194 g          411 t
ORIGIN      
        1 ctaacacttt catagcctca actggttata caagtattaa tggtaaacat ttttatttta
       61 atactgatgg tattatgcag ataggagtgt ttaaaggacc taatggattt gaatactttg
      121 cacctgctaa tacggatgct aacaacatag aaggtcaagc tatactttac caaaataaat
      181 tcttaacttt gaatggtaaa aaatattact ttggtagtga ctcaaaagca gttaccggat
      241 tgcgaactat tgatggtaaa aaatattact ttaatactaa cactgctgtt gcagttactg
      301 gatggcaaac tattaatggt aaaaaatact actttaatac taacacttct atagcttcaa
      361 ctggttatac aattattagt ggtaaacatt tttattttaa tactgatggt attatgcaga
      421 taggagtgtt taaaggacct gatggatttg aatactttgc acctgctaat acagatgcta
      481 acaatataga aggtcaagct atacgttatc aaaatagatt cctatattta catgacaata
      541 tatattattt tggtaataat tcaaaagcgg ctactggttg ggtaactatt gatggtaata
      601 gatattactt cgagcctaat acagctatgg gtgcgaatgg ttataaaact attgataata
      661 aaaattttta ctttagaaat ggtttacctc agataggagt gtttaaaggg tctaatggat
      721 ttgaatactt tgcacctgct aatacggatg ctaacaatat agaaggtcaa gctatacgtt
      781 atcaaaatag attcctacat ttacttggaa aaatatatta ctttggtaat aattcaaaag
      841 cagttactgg atggcaaact attaatggta aagtatatta ctttatgcct gatactgcta
      901 tggctgcagc tggtggactt ttcgagattg atggtgttat atatttcttt ggtgttgatg
      961 gagtaaaagc ccctgggata tatggctaaa atatatgttt gataaaaaat tattcctgtg
     1021 ctactaagaa attattttta tataataaat attgagattt aattaaaagt catgtgttat
     1081 tgtaatacat gacttttagt taaaattttt ctatcattta ataatctatt attcttgact
     1141 atttta
//
LOCUS       DAEQCW010000250         1134 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.252, whole genome shotgun sequence.
ACCESSION   DAEQCW010000250 DAEQCW010000000
VERSION     DAEQCW010000250.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.252"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            170..511
                     /locus_tag="KRO40_003640"
     CDS             170..511
                     /locus_tag="KRO40_003640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator"
                     /protein_id="HBH2094431.1"
                     /translation="MKEENFINVEYEDKRFSINSKEVLYIEKQEYEVKIYTESGNYEV
                     GENAPCIRKLLKEENFFKCSNSYIVNLDKCEFYLSNNCIFVNNNFIRILGSERKKKLK
                     KKLEKLYDYED"
     gene            662..1075
                     /locus_tag="KRO40_003641"
     CDS             662..1075
                     /locus_tag="KRO40_003641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1653 domain-containing protein"
                     /protein_id="HBH2094432.1"
                     /translation="MLELKNNLGISERKLKYPCIYKHFKGKYYATMGLSKAIDDIENI
                     CEIYGKENLIQNRNKYKLVIRHTEREEDIYVYRDLDGNFYHKKEEDTNDLVLYKTLYD
                     DTGIFARPLDMFLEKVDTDKYVNSIQEYRFEEVYK"
BASE COUNT          504 a           80 c          172 g          378 t
ORIGIN      
        1 aaaagtcttt ttaactttaa aaattaatgt taaaaaataa acttatacat taatattaat
       61 aataattatt taaatatctt aagtaaatca gtcttacata tatttccgat agattatatt
      121 gataaaaaac actaaaatta aattaataaa agtacttgga gggatggaaa tgaaagagga
      181 aaattttatt aatgttgaat acgaggataa acgtttttca attaatagta aagaagtttt
      241 gtacatagaa aagcaagagt atgaagtaaa gatttatact gaaagtggta attatgaagt
      301 tggagaaaat gctccttgta taagaaaact attgaaagaa gaaaattttt tcaaatgcag
      361 taatagttat attgtaaatc tagacaagtg tgaattttat ctcagcaata attgtatttt
      421 tgtgaataat aattttataa gaattttagg ttcagaaaga aaaaagaaat taaaaaagaa
      481 attagaaaaa ttatatgatt atgaagatta atattgggag gctgtatttt atacagcctc
      541 tttatttatt gattgtatta ttaataaatt ttaaattatg ataaaatata aaacaagtaa
      601 cttatttcag aataaaatac tttttaaaag aaagggacga gatatgggag attataataa
      661 aatgcttgaa ttaaagaata acttaggtat cagtgaaaga aagttaaaat atccttgtat
      721 ctataaacat ttcaaaggga aatattatgc tacaatgggt cttagcaagg ctattgatga
      781 tatagaaaac atatgtgaaa tatatggtaa agaaaattta atccaaaaca gaaataaata
      841 taaattagtt attagacata ctgaaagaga agaagatatc tatgtttata gggatttaga
      901 tggaaacttt tatcataaaa aagaagaaga tactaatgat ttagttttat acaagacctt
      961 atatgatgat acaggaatat ttgcaagacc tttggatatg tttttagaaa aagtagatac
     1021 agataagtat gtcaattcaa ttcaagaata cagatttgaa gaagtatata aataatataa
     1081 gagaaatatg tttataaatt tagaaaaatt ctttaacagt acaataattt gcag
//
LOCUS       DAEQCW010000251         1131 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.253, whole genome shotgun sequence.
ACCESSION   DAEQCW010000251 DAEQCW010000000
VERSION     DAEQCW010000251.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1131)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1131)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.253"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..414
                     /locus_tag="KRO40_003642"
     CDS             <1..414
                     /locus_tag="KRO40_003642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="HBH2094433.1"
                     /translation="ADCYYKSAEAGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKN
                     HAAAFVSAPDWVSAKGMRTLGNPLNGDEKVISGESGAVTTGLLVAAMEREDLADLRKD
                     LKLDENSRILLISTEGDTDPDKYRSIVWDGEYPSI"
     gene            541..>1131
                     /locus_tag="KRO40_003643"
     CDS             541..>1131
                     /locus_tag="KRO40_003643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBH2094434.1"
                     /translation="MLNEQRKQEVTEICQKLIQNPSSSGNEEGVVKAIEESFEKLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEGKIVDGKIYGRG
                     TSDMKGQYTAMMSAVAYFAKDTNRDFAGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKG"
BASE COUNT          435 a          122 c          251 g          323 t
ORIGIN      
        1 gctgattgtt actataaatc agcagaagct ggagatggaa aaccaagatt tgttggagga
       61 gatatgccaa ctataatggc agggcttgct tgtggagaac caaatactat aggatttgaa
      121 gtattaaaaa atcatgcagc agcatttgtt tcagcaccag actgggtttc tgctaaaggt
      181 atgagaacat taggtaatcc tttaaatggt gatgaaaagg taatttctgg agaatctgga
      241 gcagttacaa ctggtctttt agtagcagct atggaaagag aagatttagc agatttaaga
      301 aaagatttaa aattagatga aaattcaaga atacttttaa taagcacaga aggagatact
      361 gaccctgaca aatatagaag tatagtttgg gatggagaat atccaagtat ataaggaatt
      421 actaaaatgc aattattaga tattggttta catatttaga agatatataa gttctaaaat
      481 ttagaaaata tataagtata taaaatacat acattataaa aaatctaggg ggataatgaa
      541 atgttaaacg aacaaagaaa acaagaagta actgaaatat gccaaaaatt aattcaaaat
      601 cctagttctt ctggaaatga agaaggtgtt gtaaaagcaa tagaagagtc ttttgaaaaa
      661 ttaggttttg atagttggtc aagagataga tatggaaata tagtaggatg tataaaaggt
      721 aacaagccag gtaagaaaat attatttgat ggacatatag atacagttcc agttccagat
      781 gcaagtaaat ggagtgttcc tccttttgaa ggaaaaatag ttgatggaaa gatatatggt
      841 agaggaactt ctgacatgaa aggtcaatat actgcaatga tgtctgctgt agcgtatttt
      901 gctaaagaca ctaatagaga ttttgctgga gaactatatg tagcaggtgt tgttcatgaa
      961 gaaatatttg aaggtgtttc ggctagagag ataagtaagg ctgttcaacc tgactatgtt
     1021 gtaataggtg agtcttcaga gttaaactta aagattggtc agagaggtag aggagaaata
     1081 gtagtagaaa cttttggtaa accagctcac tctgctaatc cagaaaaagg t
//
LOCUS       DAEQCW010000252         1117 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.254, whole genome shotgun sequence.
ACCESSION   DAEQCW010000252 DAEQCW010000000
VERSION     DAEQCW010000252.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1117)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1117)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1117
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.254"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            209..919
                     /gene="rgaR"
                     /locus_tag="KRO40_003644"
     CDS             209..919
                     /gene="rgaR"
                     /locus_tag="KRO40_003644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RgaR"
                     /protein_id="HBH2094435.1"
                     /translation="MFRVVICDDEKIQRSILKEFTEKLLSERCLNYQILEFSCGEDLI
                     SKYPEKIDIIFLDIQMKDINGIEVAKKIRKFDEKVEIIFTTAFSEYAPQGYEVRAYRY
                     LVKPIEYSNFAMGVNLCIDNLQRKKERYIVLNSKKGFNRILIDSILYVETVKRDLVVH
                     TIGRDYKANMSMKQAEKLLCENGFFRCHTSFIVNLRRIEDLRDNMITINEQFIPISKY
                     RLKDLKVALTSLLCDIMY"
BASE COUNT          449 a           90 c          185 g          393 t
ORIGIN      
        1 tttattttac tatatttttt tacataatat atctagaaaa gtataggaat ttatcgtaat
       61 ttaagtttaa atattaaaga gaatttctat aagtagttta atcgacaatt taaatttata
      121 aagaaattta aatttgaaag ctagtgagta cagtttggaa attgaaataa agtaaactaa
      181 atgatatttt agatttggag gtgatattat gttcagggta gttatatgtg atgacgaaaa
      241 aatacaaaga agcatactaa aagagtttac agaaaaactt ttgtctgaaa gatgtctaaa
      301 ttatcaaata ctggaatttt cctgtggaga agatttaata tccaaatacc cagaaaaaat
      361 tgatattata tttttagata tccaaatgaa agatatcaat ggaattgagg tggctaaaaa
      421 aataagaaag tttgatgaaa aagtagaaat tatatttaca acggcttttt cagagtatgc
      481 cccccaaggt tatgaggttc gtgcttatag atatttagta aagcctatag agtatagtaa
      541 ctttgcaatg ggtgtaaatc tttgtattga taaccttcaa agaaagaagg agcgttatat
      601 agttttaaat agtaaaaaag gatttaatag aatactgata gattctattt tatatgttga
      661 aactgtaaag agagatttag tcgtacatac aataggtaga gattataaag ctaatatgag
      721 catgaaacaa gcagaaaaat tactgtgtga aaatggcttt tttagatgtc atacaagttt
      781 tattgttaat ttaagaagaa tagaagatct tagggataat atgattacta ttaatgaaca
      841 atttatacct ataagtaagt atagacttaa agatttaaaa gtagcattaa caagcttgtt
      901 atgtgatata atgtattaat tttaaaaagg taattgaaaa tatcgtaaaa aagatttaat
      961 gtcatcacag ggctattgat tgaaactgtc ttaatatata aaatgttatt tatattaaga
     1021 cagttttatt atgcaaaata gcagtttata gatttttaat atggtttaac atgtatatgt
     1081 agagtttcca ttataatagc atgattatta attagta
//
LOCUS       DAEQCW010000253         1089 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.255, whole genome shotgun sequence.
ACCESSION   DAEQCW010000253 DAEQCW010000000
VERSION     DAEQCW010000253.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.255"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            269..967
                     /gene="tcdC"
                     /locus_tag="KRO40_003645"
     CDS             269..967
                     /gene="tcdC"
                     /locus_tag="KRO40_003645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin anti-sigma factor TcdC"
                     /protein_id="HBH2094436.1"
                     /translation="MFSKKNEGNEFSNEGKGSSKKIIKFFKSTKGIALLAFILGVFFG
                     NISSPACSEDHEEVISNQTSVIDSQKTEIETLNSKLSDAEPWFKMKDDEKKAIEAENQ
                     RKAEEAKKAEEAKKAEEQRKKEEEEKKGYDTGITYDQLARTPDDYKYKKVKFEGKVIQ
                     VIEDGDEVQIRLAVSGNYDKVVLCSYKKSITPSRVLEDDYITIRGISAGTITYESTMG
                     GNITIPGIAVEKIN"
BASE COUNT          435 a          111 c          180 g          363 t
ORIGIN      
        1 taattacatc ataatatagt tttatacaaa taaaatactt tatgtttaat ttaatatata
       61 aaattcacct tcaagaaaat tatattataa tctgacattt ttatcttatt ttttcaaaat
      121 atattgaatc ttcttacttt attttgtaaa attatgctta ggggaaatat attttaggaa
      181 aatatgaata tataattttt agtcaactag ttattttaag tttttaactt ttaaaataaa
      241 atatatctaa taaaagggag attgtattat gttttctaaa aaaaatgagg gtaacgaatt
      301 tagtaatgaa ggaaaaggaa gctctaagaa aataattaaa ttctttaaga gcacaaaggg
      361 tattgctcta ctggcattta ttttaggcgt gttttttggc aatatatcct caccagcttg
      421 ttctgaagac catgaggagg tcatttctaa ccaaacatca gttatagatt ctcaaaaaac
      481 agaaatagaa actttaaata gcaaattgtc tgatgctgaa ccatggttca aaatgaaaga
      541 cgacgaaaag aaagctattg aagctgaaaa tcaacgtaaa gctgaagaag ctaaaaaagc
      601 tgaagaagct aaaaaggctg aagaacaacg caaaaaagaa gaagaggaga agaaaggata
      661 tgatactggt attacttatg accaattagc tagaacacct gatgattata agtacaaaaa
      721 ggtaaaattt gaaggtaagg ttattcaagt tattgaagat ggtgatgagg tgcaaataag
      781 attagctgtg tctggaaatt atgataaggt tgtactatgt agttataaaa aatcaataac
      841 tccttcaaga gtattagagg atgattacat aactataaga ggtataagtg ctggaactat
      901 aacttatgaa tcaactatgg gtggaaatat aactatacca gggatagctg tagagaaaat
      961 taattaatat tgttttgtat tatagttaat attttatatt atagtcaata tgtttaaaga
     1021 tgtttttata attgcaaata aacagttaca aggctctaaa ttagtttttg cttttagcat
     1081 attatctat
//
LOCUS       DAEQCW010000254         1082 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.256, whole genome shotgun sequence.
ACCESSION   DAEQCW010000254 DAEQCW010000000
VERSION     DAEQCW010000254.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1082)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.256"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            121..822
                     /locus_tag="KRO40_003646"
     CDS             121..822
                     /locus_tag="KRO40_003646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HBH2094437.1"
                     /translation="MERTQQLKESFIASIPIFLGYIPIGIVGGILLQKSGLSPFQIAL
                     MVTLVFGGSSQFIAASMISTGASVTSIVLTTFIVNLRHFLMSSNLNMYIKNKSPKFIL
                     PFCHTITDETFAVNYEKFTAGNWSDRNAIYLNFFCLISSVLANFIGAFLGESISIDSS
                     ISGFILTSMFIALIVSQIKNKIYIVVFISSIIISVILYALFKSNLVIIVASILASLIG
                     FFIEESYCKKEESYE"
     gene            815..>1082
                     /locus_tag="KRO40_003647"
     CDS             815..>1082
                     /locus_tag="KRO40_003647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HBH2094438.1"
                     /translation="MNNNYIFFIIIGMYIVTYLPRVLPMLIFSKKEMPDFLKKIMKFI
                     PVAILTSLTAKDVFFNGDSLYLSIANPKIISFMIVLLVAYKFKSI"
BASE COUNT          369 a          130 c          136 g          447 t
ORIGIN      
        1 gtatagtatt ttatatatta atccaaattt atttttaatt ataattgcaa ttatacaatt
       61 aatctatttt tctgttttac gaatacttta atacatttaa tacaaaagga gtgatttatt
      121 gtggaaagaa ctcaacaatt aaaagaaagc tttattgctt caattcctat attcttaggt
      181 tatataccta taggtatagt aggaggaata ctattacaaa aatctggtct ttcacctttt
      241 caaatagcac taatggtaac tttagtattt ggaggaagtt ctcaattcat tgcagcttca
      301 atgatttcta ctggtgcaag tgtaacatct attgttttga ctacatttat agttaactta
      361 agacattttc taatgagttc taatttgaac atgtacataa aaaataaaag tccaaaattt
      421 atattgccat tttgtcatac tataacagat gaaacttttg cagttaatta tgaaaaattt
      481 actgctggaa attggtctga tagaaatgct atttatctta atttcttctg cttaatttca
      541 tcagttttag ctaattttat tggagcattt ttaggagaaa gtatatctat agacagttct
      601 atttctggct tcatattgac ttctatgttt atagctttaa tagtttctca aataaaaaat
      661 aagatttata ttgtagtatt tatatcatca atcattattt ctgttatttt atatgcatta
      721 ttcaaaagca atttagtaat aatagttgca tcaattttag catctttaat tggtttcttt
      781 atagaagaat cttactgtaa aaaggaggaa tcttatgaat aataattata tattttttat
      841 tataattgga atgtacattg ttacatatct accaagagtg cttcctatgt taattttttc
      901 aaaaaaagag atgcctgatt ttttgaaaaa aatcatgaaa tttatacctg tagcaatact
      961 tacttcctta actgctaaag atgtattttt taatggagat agtctatatt tatctatagc
     1021 taaccctaaa attatatctt ttatgattgt acttcttgtt gcatataagt ttaaatctat
     1081 tg
//
LOCUS       DAEQCW010000255         1040 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.257, whole genome shotgun sequence.
ACCESSION   DAEQCW010000255 DAEQCW010000000
VERSION     DAEQCW010000255.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1040)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1040)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1040
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.257"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            23..697
                     /locus_tag="KRO40_003648"
     CDS             23..697
                     /locus_tag="KRO40_003648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBH2094439.1"
                     /translation="MNHHILIQFEYIARIITAGFCGALIGYERKNRLKEAGIRTHFIV
                     ALASALIIIVSKYGFNDIVGTPGIGLDPARVAAQVVSGIGFLGAGLIFIRNQSVSGLT
                     TAAGIWATAGTGLAIGSGLYLVGIVSSIIIVIVQITLHRDRKWMKLPTAEQVSLKISN
                     STDSIEYIEGKFKKSNIEIINMNIKRLDGDWLEVVIYTKLPKGYKKTNLLKLFSDNPL
                     IETLEI"
BASE COUNT          369 a          132 c          168 g          371 t
ORIGIN      
        1 tatagaaggg ggtgctagat aaatgaacca tcatatattg attcaatttg aatatatagc
       61 aagaatcatt actgctggtt tctgtggggc tttaattgga tatgagagaa agaatagact
      121 aaaagaagct ggaatacgca ctcattttat agtggcatta gcttcagcac ttataatcat
      181 tgtttccaag tatggattta atgatatagt gggtactcca ggtattggtc tagacccagc
      241 ccgcgttgca gcacaagttg tcagtggtat aggtttttta ggtgctggat taatatttat
      301 tagaaatcaa tcagtaagtg gtcttactac agctgctggt atatgggcaa cagctggtac
      361 aggtcttgcc attggctctg gattatactt agttggtatt gtttcaagta tcattattgt
      421 tattgtacag ataacacttc atagagatag gaaatggatg aaactcccta cagcagagca
      481 agtttctctt aaaatttcta acagcactga ttccatagaa tatattgaag gtaaatttaa
      541 aaaatctaat attgaaatta taaacatgaa tattaaacgc cttgatgggg attggttaga
      601 agtagttata tatactaagt tacctaaagg atataaaaaa acaaatttat taaaattatt
      661 tagcgataat cctcttatag aaactttaga aatataatat aaaaattgaa gcttaaaaat
      721 aataatatat ttaatcaagg tcaatatata aataattacg ggatgagtct atataaaatt
      781 catcccttgt tttttgccat tcatatatat tttttcaaga tatttttgtt catctattat
      841 ctagccaagt aactcttgtg aactaaactt tttaatacaa aaacttcaat acaaaactaa
      901 atataatttt tattaaatat tctacatgta tagtttattt cttgagtgaa aaatagattt
      961 catattgtta agatactgtt aaatatttca attttctgac aagtatgttg aacaataact
     1021 tatcctagtg tattatttta
//
LOCUS       DAEQCW010000256         1039 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.258, whole genome shotgun sequence.
ACCESSION   DAEQCW010000256 DAEQCW010000000
VERSION     DAEQCW010000256.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1039)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1039)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1039
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.258"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(314..>1039)
                     /locus_tag="KRO40_003649"
     CDS             complement(314..>1039)
                     /locus_tag="KRO40_003649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2094440.1"
                     /translation="YVSAYHKENLEAKSANKVYKIGGGLTSKVMSSIASSLSKHNTTP
                     TEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIREKDYTLNTSLATTEYLRSKGFNVIM
                     TRDTDKTLSLGNRTALSNSLRPDLFTSIHYNASDTTGNGVEVFYKLKDKDGGTTKTVA
                     TNILNRILEKFNLKNRGAKTRTLSTDPTKDYLYVLRNNDMPAVLVECAFLDNEKDMSL
                     LNTSNKVKEMGTQIGKGIEDSLK"
BASE COUNT          318 a          183 c          123 g          415 t
ORIGIN      
        1 tgacataaaa atccacaaaa aacacacaaa cacacaataa aatatagtaa ttaagctttt
       61 attgtgtatt acaaatgaat actccaactc ttgacaatta actgtagcct taagatatgt
      121 aaattcttca tataatataa atccttttac aattaatcat aaaaagactg tatatacctc
      181 atttcgcact tatatgcaca atgtatatac agtctttatt actattataa ttacattctt
      241 atcttatagc tttagtttaa atttaaaatt gcagattaat ttattttaaa tttttctatg
      301 ctctcattgt agactatttt aatgaatctt ctatgccttt acctatttgt gtacccattt
      361 cttttacttt atttgatgta ttaagtaaac tcatatcttt ctcattatcc aaaaatgcac
      421 attctacaag tacagctggc atatcattat ttcttaaaac atataaataa tcttttgtag
      481 ggtcagttga tagtgttctt gtttttgcac ctctattttt tagattaaat ttctctaaga
      541 ttctatttaa tatatttgta gctacagttt tagtagtccc tccatcttta tctttaagct
      601 tataaaatac ttctacacca ttcccagttg tatcagatgc attatagtgt atactcgtaa
      661 ataaatctgg tctcaaagag ttagataaag cagttctatt tccaagagat aaagtcttat
      721 ctgtgtctct tgtcattatt acattgaatc cctttgaacg taaatattca gttgtcgcaa
      781 gtgaagtatt taatgtatag tctttttctc taataccccc taatggttta cctgttgttc
      841 cagtgtccga accaccatgt cctgggtcaa tcataactgt cttgccccca ctatttcctg
      901 gttctgttgg agttgtattg tgtttagata atgatgatgc tatagagctc attaccttag
      961 aagtcaatcc tccacctatt ttatatacct tatttgccga tttagcttct aagttttctt
     1021 tatggtatgc agatacata
//
LOCUS       DAEQCW010000257         1038 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.259, whole genome shotgun sequence.
ACCESSION   DAEQCW010000257 DAEQCW010000000
VERSION     DAEQCW010000257.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1038)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.259"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            29..898
                     /locus_tag="KRO40_003650"
     CDS             29..898
                     /locus_tag="KRO40_003650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBH2094441.1"
                     /translation="MEYDMPLYRPPSEAYSLIIQVTLGCSHNKCTFCSMYKSKKFKIK
                     PLEVIKNEIDIFRRYYKHVERIFLADGDALIIPMEKLRDIILYIKEVFPECERITMYG
                     SPKSIEKKSDDELKELRKLGVKMIYLGLESGSNEVLEDIKKGFSSEQLIKVGRKVKKS
                     GIKLSATVIAGLGGTKKTHQHAVDTGKMLGAISPDYVGVLSLMVEPNTELYDLLKAGE
                     FTILEDKAVLQEIKEMIKNIDANEKIVFRSNHASNYANLKGVLPDDKQRLIDEIDYYL
                     SNQKLKREEYRRL"
BASE COUNT          431 a          104 c          184 g          319 t
ORIGIN      
        1 aatattttat tacaaggggg attttaatat ggaatacgat atgccacttt acagaccacc
       61 aagtgaggct tatagtctta taatacaagt cacactagga tgttctcata acaaatgtac
      121 gttttgtagt atgtacaaat ctaaaaaatt taaaataaag ccactagaag taataaaaaa
      181 tgaaattgat atatttagaa gatattataa gcatgtagaa agaatattct tagcagatgg
      241 agatgcattg ataataccaa tggagaaatt aagagatatt attttatata taaaagaagt
      301 ttttccagag tgtgaaagaa ttactatgta cggctctcct aaatctatag agaaaaaatc
      361 tgatgatgaa cttaaagaat taagaaaact tggtgttaaa atgatttatc tagggcttga
      421 aagtggaagc aatgaagtat tagaagatat taagaaaggt tttagtagtg aacaattaat
      481 aaaagttggt agaaaagtta aaaaaagtgg gattaaatta tcagccactg taatagcagg
      541 tcttggagga actaaaaaaa cacatcagca tgcagttgat acaggaaaaa tgttaggagc
      601 aatttcacca gattatgtgg gtgtacttag tttaatggta gaacctaata ctgaacttta
      661 cgatttactt aaggcaggag agtttacaat actagaggat aaggctgtgt tacaagaaat
      721 taaagagatg ataaagaata tagatgctaa tgaaaaaatt gtatttagaa gtaatcatgc
      781 atcaaattat gctaatttaa aaggtgtatt acctgatgat aaacaacgtc taattgatga
      841 aattgattac tatctaagta accaaaagct aaaaagagaa gaatatagaa gactatagtt
      901 tttgatatat caatctatat tgataggtaa atactaagat tatttagata caaaaaatca
      961 tgctacatta atagttgctt actattgatg tagcatgatt tttttattaa aaaacaaaat
     1021 ggtatattca tatataat
//
LOCUS       DAEQCW010000258         1038 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.260, whole genome shotgun sequence.
ACCESSION   DAEQCW010000258 DAEQCW010000000
VERSION     DAEQCW010000258.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1038)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.260"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(56..664)
                     /locus_tag="KRO40_003651"
     CDS             complement(56..664)
                     /locus_tag="KRO40_003651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dienelactone hydrolase family protein"
                     /protein_id="HBH2094442.1"
                     /translation="MVDNLIKYIHKSDVAIVVLHEIYGINSFIEDVCQKYYKYGYDVF
                     CPELLGEKRVFPYSKVQEAYDFFINNVGFDIYKKVEKLINDLKSEYKYVFVAGYSVGA
                     TIAWRCSEDSFCDGIICCYGSRIRDYMDVIPKCPTLLVFAKHDSFDVDSISCQLSRKQ
                     NIQIEILDANHGFIDRYSNNYSDIQTKVFTIKEKSFLSKYLA"
     gene            complement(924..>1038)
                     /locus_tag="KRO40_003652"
     CDS             complement(924..>1038)
                     /locus_tag="KRO40_003652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBH2094443.1"
                     /translation="AKELGLDAIHDTVHEMCKDEARHGKAFLGLLNRYFGK"
BASE COUNT          390 a          170 c           86 g          392 t
ORIGIN      
        1 cataaaaact tttcagatta attaaatctt tctatatatt ttataatagt ctaaatcatg
       61 ctaaatattt agacagaaaa cttttttctt taatagtaaa tacttttgtt tgaatatcag
      121 aataattatt tgaatatcta tctataaaac catgatttgc atctaaaatc tcaatttgga
      181 tattttgttt cctagaaagt tggcaagaaa tagaatcaac atcaaatgaa tcgtgctttg
      241 caaatactaa taaggtagga cattttggaa ttacatccat gtaatctcga atccgagagc
      301 cataacaaca aattatgcca tcacaaaaag aatcttcact gcatctccat gcaatagttg
      361 ctcccacgct atacccagca acaaatacat atttatactc tgattttaaa tcatttataa
      421 gcttttcaac ttttttataa atatcaaaac caacattatt tataaaaaaa tcatatgcct
      481 cttggacttt tgaatatgga aaaactcttt tttctcccag aagttcagga caaaatacat
      541 catatccata tttataatac ttttgacaaa catcttctat aaagctatta atcccataga
      601 tttcatgcaa aacaacaata gctacatcac ttttatgtat atactttatc agattatcca
      661 ccacctttac aaaacagcaa attttttata cttagtttaa tatattcttc tttacatgtc
      721 aatttacttt tctaaaatca aatttatttt tggattaatc atttattttt aaaagttgtg
      781 cattattact attaaattat tctctattat taaaaatata atcgttagaa ataaaaaata
      841 aagtacaaat aattaaaaaa tatctcactc ataactttaa aaattataag tgagatactc
      901 ctaaaatcta ctttatatta aatttatttt ccaaaatatc tatttaataa tcctaagaat
      961 gctttaccat gtctagcttc atctttacac atttcatgta ctgtatcatg tatagcatct
     1021 aatcctaatt cttttgct
//
LOCUS       DAEQCW010000259          976 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.261, whole genome shotgun sequence.
ACCESSION   DAEQCW010000259 DAEQCW010000000
VERSION     DAEQCW010000259.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 976)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 976)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.261"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(188..871)
                     /locus_tag="KRO40_003653"
     CDS             complement(188..871)
                     /locus_tag="KRO40_003653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HBH2094444.1"
                     /translation="MTSKSQMSESFFLCSLLAITGGFLDIYTYVVRGKVFANAQTGNI
                     VLFGLNIAEGNVKESFYYLIPILAFMLGVFIAEKIRKYFTNNKTKIHWRQVIIIIEMI
                     TILIVSFIPRGRFNMFVNVAISFICSMQVESFRKVNGNSFATTMCTGNLRSATETLFH
                     YIHTKNIFMIKKSLQYYAIIIFFISGAILGTFFTKIFVEKSILICFFILAVVFGIMFI
                     NKDDSFNEN"
BASE COUNT          382 a          157 c           78 g          359 t
ORIGIN      
        1 tctatatatt gcctactata cttaagacat tttaattaat ttatacactg cttactatac
       61 ttaaaatact tctattaact tatacattgc ttactatatt ttaaattctt taattaatct
      121 atacaatatt tgctatatat aaagtatatc aaataacagc ttcatttttt tgtaaattta
      181 cagaaagtta attttcatta aatgaatcat ctttattgat aaacataatt ccaaagacca
      241 ctgccaaaat aaaaaaacat attagtattg atttttccac gaaaattttt gtaaaaaaag
      301 ttcctaaaat agctccagat ataaagaata taataatagc ataatactgt aaactctttt
      361 ttatcataaa aatattctta gtatgtatat aatgaaataa agtttctgta gcacttctta
      421 aatttccagt acacattgtc gttgcaaaac tattcccatt tacttttcta aaactctcta
      481 cttgcattga acaaataaaa gaaatagcaa catttacaaa catattaaat cttcctctag
      541 gaataaatga aacaataagt attgtaatca tttcaattat aatgataacc tgacgccaat
      601 gaatctttgt cttattattt gtaaaatact ttcttatctt ctcggctata aatacaccta
      661 acataaatgc caaaatagga atcaaataat aaaatgattc ctttacatta ccttctgcta
      721 tattaagccc aaacaaaact atatttccag tttgtgcatt agcaaagact ttacctctta
      781 ccacataagt ataaatatcc aaaaatcctc ctgttattgc caacaaagaa cataaaaaga
      841 atgattcaga catctgactc ttgcttgtca tatataaacc tctcgctttc taatgataga
      901 tacaaaatca aaatcatttt agattctatt tttcattgat ataaaaaaat tatttatatt
      961 taaatattgt ctatat
//
LOCUS       DAEQCW010000260          956 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.262, whole genome shotgun sequence.
ACCESSION   DAEQCW010000260 DAEQCW010000000
VERSION     DAEQCW010000260.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 956)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 956)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.262"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            22..774
                     /gene="cwlD"
                     /locus_tag="KRO40_003654"
     CDS             22..774
                     /gene="cwlD"
                     /locus_tag="KRO40_003654"
                     /EC_number="3.5.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase CwlD"
                     /protein_id="HBH2094445.1"
                     /translation="MEYYSVFISIHIQGDVVRKYIKHIIFSFAMICLVVVSIFEIKNI
                     SEDVIKYMPVTNKTIILDAGHGGIDPGALNKDKSTSEKDINLAITLKLRELIESSGGL
                     VILTREDDSSLYKEENNKTTRQKYNENLKNRKEIISNSNANMFVSIHLNAFEQSKYYG
                     AQTFYPKDKQDSKELSKCIQEELKRVVDKTNNREVKPRDDIYLLKENNIPSVLIECGF
                     LSNEKECKLLTDETYQEKIAWAIYIGIQKYLS"
BASE COUNT          415 a          103 c          152 g          286 t
ORIGIN      
        1 tttaaatgtt tgtactaata tatggaatat tatagtgttt ttataagtat acatatacag
       61 ggtgatgttg tgagaaagta cataaaacat ataattttta gctttgcaat gatatgtcta
      121 gtagtagtat ccatatttga aattaaaaat atttctgaag atgttatcaa gtatatgcca
      181 gtaacaaaca aaactataat tttagatgct ggtcatggag gcattgatcc aggtgcatta
      241 aataaggata agagtacatc tgaaaaggat attaacctag caataacact taagcttaga
      301 gagcttatag aatcaagtgg tggccttgta atattaactc gagaagatga cagtagcctt
      361 tataaagaag aaaataataa aactacaaga caaaaatata atgagaattt gaaaaataga
      421 aaagaaataa tatctaattc taatgccaat atgtttgtct ctatacatct taatgcattt
      481 gaacaatcaa aatactatgg agctcaaact ttttatccta aagacaaaca agacagtaaa
      541 gaattatcga agtgtattca agaagaactt aaaagagtag tagataagac aaacaacaga
      601 gaagtcaaac caagggatga tatatatctt ttgaaagaaa ataatattcc atcagtactg
      661 atagaatgtg gttttttatc aaatgaaaaa gagtgtaaac tcttaactga tgaaacatat
      721 caagaaaaaa tagcatgggc aatctacata ggaatacaaa aatatttaag ttgaaataac
      781 tataaaaata ggtctaaata tgtaaatagc ttgtattaaa gcagttaaaa tgcattaata
      841 taggctattt ttattttgac aaaaaaatat ttaaaataaa agttaaaaag ttgttgactt
      901 agaataatat agatgatatt atatatgagt gcccaaaagg agcaccaaaa taagac
//
LOCUS       DAEQCW010000261          936 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.263, whole genome shotgun sequence.
ACCESSION   DAEQCW010000261 DAEQCW010000000
VERSION     DAEQCW010000261.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 936)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.263"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(102..608)
                     /locus_tag="KRO40_003655"
     CDS             complement(102..608)
                     /locus_tag="KRO40_003655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase"
                     /protein_id="HBH2094446.1"
                     /translation="MGFREVKIEELQFNPFTKIGKEWLLITAGDSEKFNTMTASWGGV
                     GVYWGKNVVTTYIRPQRYTKEFVDSNDTFTIAFFDETYREALNICGTISGRDINKIEK
                     AGLTPYFVDDTVAFEEANMIIVCKKLYHGNMPPENFDAKENDKKWYPEKDYHTMYISE
                     IIKVLVKE"
BASE COUNT          322 a          142 c           89 g          383 t
ORIGIN      
        1 aaattaatat ttatttagtt agtagcatct acttagatat cagataagaa agcacagtca
       61 tttacttata ataagttctt ttcatatatt ttttattata attattcttt tacaagaact
      121 tttataattt ctgaaatgta catagtatga tagtctttct ctggatacca ttttttatca
      181 ttttctttag catcaaagtt ttctggtggc atattaccat gatatagctt tttacatact
      241 ataatcatat tagcttcttc aaaagctacc gtatcatcca caaaatatgg tgtaagtcct
      301 gctttttcta ttttatttat atctctacca gaaatagtgc cacaaatatt taaagcttct
      361 ctatacgttt catcaaagaa ggcaattgta aatgtatcat tactatctac aaattctttt
      421 gtatatctct gtggtcttat gtaagttgta acaacatttt taccccaata gactccaaca
      481 ccaccccagc tagcagtcat tgtgttaaac ttttctgaat caccagctgt tataagtaac
      541 cattctttgc caatcttagt aaatggatta aactgtaatt cctcaatttt tacttctcta
      601 aaacccatga cttcatccta cccttcattt tttaattata taaattaatt gttaaaaatt
      661 tgaatatatg tactcttata atactgactt ttgattgtcc tacataattc atgtaaatta
      721 taatacaaca aatcaattac tttcgcaata agtagttttc atattttata agtgtaaaat
      781 atagataaaa tatattgatt ataaagtata taatatattt ttaaacctaa agcaatatac
      841 aataaaaaaa tgtagaaagt aagtatctct ctacattttt tattgtatat tatttttata
      901 ttaatttaat tttatcttga ttcagtttta taaaaa
//
LOCUS       DAEQCW010000262          934 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.264, whole genome shotgun sequence.
ACCESSION   DAEQCW010000262 DAEQCW010000000
VERSION     DAEQCW010000262.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 934)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.264"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            193..843
                     /locus_tag="KRO40_003656"
     CDS             193..843
                     /locus_tag="KRO40_003656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBH2094447.1"
                     /translation="MKVKSNLDEILYHKIIESLIRGEYSVGQKILLNDLCEKFEVSRT
                     PVVQAVKMLNKDGVLTIMTNGKVYVPEYEYDMVKQVCETRTLIETYALEKMMQEEEEV
                     FQQKLDVIKRYSDKCEEYYRQEKSVELALADLELHKAIVEGANNEILNDVYVGIQGRF
                     IVVNYLIRPLKNRNYEGTVQDHFEILKFIEDRDTKKAVDKLRNHIQGTIKRFCEDE"
BASE COUNT          405 a           93 c          159 g          277 t
ORIGIN      
        1 agtacaataa cttgatttgc aatacaatga attaatctat agtataagag catgatttac
       61 agtacaataa tttaaattgt agtacaaaag tactatcaaa taagaatttc tactttaaaa
      121 atattactaa aagtaattaa agtccagtaa ttcaatataa tatggcaaaa gaatagaaat
      181 aaggtgagag tagtgaaagt aaagtcaaat ttagatgaaa ttttatatca taagattatt
      241 gaaagtctta ttcgtggtga atactctgta ggtcaaaaaa tattactaaa tgacctttgt
      301 gaaaaatttg aagtaagcag aacaccagtt gtacaagcag taaaaatgct aaataaagat
      361 ggagtgctta ctattatgac aaatggtaaa gtgtacgtac cagagtatga atatgatatg
      421 gtaaaacaag tttgtgaaac gagaacactg attgaaacat atgctttaga aaaaatgatg
      481 caagaagagg aagaggtttt tcaacaaaag ctagatgtaa taaaaagata ctctgataaa
      541 tgcgaggagt actatcgtca agaaaaatct gtagaacttg cactagcaga tttggaatta
      601 cataaagcca ttgtagaagg ggcaaataat gagattttaa atgatgtata tgttggtata
      661 caaggaagat ttatagtagt gaactattta attcgaccat taaaaaatcg taattatgaa
      721 ggaacagtac aagaccattt tgaaatatta aaattcattg aagacagaga tacaaaaaaa
      781 gcagtagata aactaagaaa tcatattcaa ggaactatta aaagattctg tgaagatgaa
      841 taataagttt tgaagttact atatatactt atctattaag ttgctaaatg tagtctaagt
      901 ataatctaat tatagtttaa acataatcta aata
//
LOCUS       DAEQCW010000263          934 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.265, whole genome shotgun sequence.
ACCESSION   DAEQCW010000263 DAEQCW010000000
VERSION     DAEQCW010000263.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 934)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.265"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            290..757
                     /locus_tag="KRO40_003657"
     CDS             290..757
                     /locus_tag="KRO40_003657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HBH2094448.1"
                     /translation="MKFLNVLVVVEDIEKSKKFYYDVLGLKVICDFGENVVLEGNISL
                     QEKKLWLEFINKSDSEVKFNGNDAELYFEEDNFDTFVERLSTMKDIDYVHLAIEHRWG
                     QRAIRFYDLDGHIIEVGETMSSVCRRFLDSGLSIDEVAKRMDVTVEYIESVLE"
BASE COUNT          355 a           64 c          158 g          357 t
ORIGIN      
        1 tattaatatt cccttgaaat taaaaaaaca tagatatttc agtaatctaa aatagtctac
       61 aaaaataaca gttttagcaa aattaataag aatacatata gatttaaacc taaaagtatg
      121 aacatgtctg ttttttacaa gattaaaatt tatattatat gataaaatta acttaactat
      181 ttcaataaga cttataattt ttttctttat actagacctt attgaaacct ttatagttta
      241 attctaatta tatattataa ataaagtatg tgtatattaa ggaggtaata tgaagttttt
      301 aaatgtttta gtagtagttg aagatattga gaaatcaaaa aagttttatt atgatgtttt
      361 ggggttaaag gtaatctgtg attttggaga aaatgttgta ttagaaggta atatatcatt
      421 acaagaaaaa aagctttggt tagaatttat taataagagt gacagtgaag ttaagttcaa
      481 tggaaatgat gctgagttat attttgagga agataatttt gatacttttg ttgaaagatt
      541 gagtacaatg aaagatatag attatgttca tctagctata gagcataggt ggggtcaaag
      601 agcaattaga ttttatgatt tagatgggca tattattgag gttggagaaa ctatgtcatc
      661 tgtgtgtaga cgttttttag atagtggtct ttcaatagat gaggtagcta aaagaatgga
      721 tgtaactgtc gaatatattg aatcagtttt agaatagatg gattatatta aagtaaaatt
      781 gaggtgaagg ctgtaagtaa acttgtgtga aaacaaattt gcttacagtt tttatttttc
      841 taaaataaag aatataatac ttgtttagct ttatttgagt ttttaaaaat attatgatat
      901 ttcttatata tttatactaa agtttaaatt taga
//
LOCUS       DAEQCW010000264          924 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.266, whole genome shotgun sequence.
ACCESSION   DAEQCW010000264 DAEQCW010000000
VERSION     DAEQCW010000264.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 924)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.266"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            14..391
                     /gene="tnpA"
                     /locus_tag="KRO40_003658"
     CDS             14..391
                     /gene="tnpA"
                     /locus_tag="KRO40_003658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002320594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBH2094449.1"
                     /translation="MVYDCKYHIVFCPKYRKPVLVGEVEKMLKEILPYKADELGAEII
                     EMETDKEHVHLLISCDPQYGIHKVVKGLKGFSSRVLRENFPHLKSSMPSMWTNSYFVG
                     TVGSVSLEVVKQYIENQQVRTKK"
     gene            388..>924
                     /locus_tag="KRO40_003659"
     CDS             388..>924
                     /locus_tag="KRO40_003659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2094450.1"
                     /translation="MIKTHRVKLNLTRTQFELVREKQMESANCWNYIVNLSKEYYFEH
                     KQWIKKNDIQKLIKGKYNLHSQTIQAISDKFDANRKTISELRKKGNTKAKYPYKTKKF
                     YIIPFKASAINRNAKGNLKLSMSKGRYLELDFNVENIKTAEIVWRNGYYLYYTFDNEL
                     NGVVAKGTNTVGVDLGEIH"
BASE COUNT          390 a          106 c          158 g          270 t
ORIGIN      
        1 atctaacaaa aatatagttt atgattgcaa atatcatatt gtattttgcc ctaagtatcg
       61 taaacctgtt ttagttggcg aagttgaaaa gatgttaaaa gaaatactac catataaagc
      121 agatgaactt ggagcagaaa taatagaaat ggaaactgat aaagaacatg tgcacttatt
      181 aatatcttgt gaccctcaat atggaattca taaagtagta aaaggtttaa aaggctttag
      241 ttcgagagta ttaagagaga actttccaca tttaaagtct agtatgccta gcatgtggac
      301 taatagctat tttgtaggta ctgttggttc tgtgagttta gaagtagtta aacaatatat
      361 agaaaatcaa caagttagga caaagaaatg ataaaaactc atagagtaaa attaaaccta
      421 actagaacac aatttgaatt agtaagggaa aagcaaatgg aaagtgctaa ctgttggaac
      481 tacatagtta acttatctaa agaatactat tttgaacata aacaatggat taaaaagaat
      541 gatatacaaa agttaatcaa aggtaagtac aatcttcata gtcaaactat tcaagctata
      601 tcagataaat ttgatgcaaa tagaaagact atatcagaat taagaaaaaa aggtaatact
      661 aaagcaaaat atccatacaa gactaagaaa ttttatataa taccttttaa agctagtgct
      721 attaatagaa atgctaaagg caacttaaaa ttatcaatgt caaaaggcag gtatttagaa
      781 ttagatttta atgttgagaa tataaaaact gctgaaatag tatggcgaaa tggatattat
      841 ttatactaca cttttgacaa tgaattaaat ggagttgtag ccaaaggcac taataccgta
      901 ggtgtagact taggggaaat acat
//
LOCUS       DAEQCW010000265          899 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.267, whole genome shotgun sequence.
ACCESSION   DAEQCW010000265 DAEQCW010000000
VERSION     DAEQCW010000265.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 899)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 899)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.267"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     repeat_region   51..409
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=51..79
                     /rpt_unit_seq="atttacattccatatagttaatataaaac"
BASE COUNT          347 a          124 c           94 g          334 t
ORIGIN      
        1 gttaatataa aactagatat ttaaaataag cgaaaggggg tcataaaaat atttacattc
       61 catatagtta atataaaaca ttctaaagat attttgcctt gcagttggga tttcgaattt
      121 acattccata tagttaatat aaaaccatca taggggctaa tatagttaaa ggtgttggcg
      181 tatttacatt ccatatagtt aatataaaac ggtttggtta caaggtatag tagaaggata
      241 tagtggaatt tacattccat atagttaata taaaacatgg aactaagaga gtacaccatc
      301 acatgatact caaatttaca ttccatatag ttaatataaa actaaagctg gaaaagaaac
      361 agctataatg agtaataata atttacattc catatagtta atataaaacc ccaaaataaa
      421 cttagtattt tcaatactta cacgtataca actctcttaa atttgcagtg aacgagcaat
      481 agtgcaattg ataacgctta tcatacactc tcaacgcctt atatttcaac tgttacgcca
      541 aattttttca caaatatcgc tcactgcaaa attcctataa ttttattata tcataaatat
      601 attacttttg aatattgata ctaatttata ccataataaa agcaaaaaaa cgtaatctat
      661 ctacattaga tttaaattct ataacttaaa gttttttaca taatatttat gcttgtttaa
      721 tcaatctaat atatcattct tgtatattgc ttttaatagt cttttttctt aaataaatat
      781 ctatctgaac aagcatagtt taattaaaaa cttttgtatt cccttaaaac tgtatctacc
      841 tcttattatt ttatttatga tatattattt ttaatctaaa aatagatatc tatttttat
//
LOCUS       DAEQCW010000266          896 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.268, whole genome shotgun sequence.
ACCESSION   DAEQCW010000266 DAEQCW010000000
VERSION     DAEQCW010000266.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 896)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 896)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.268"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            169..711
                     /locus_tag="KRO40_003660"
     CDS             169..711
                     /locus_tag="KRO40_003660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBH2094451.1"
                     /translation="MKICITVGHSILKGGKSTGVNGIVDEYNYNKKLAPMLAEMLISQ
                     GNTVDVIICPERHFMSEREEFFYRVPKVNSGKYDLLVELHLNKADGTQCGTEVLYYGT
                     EGLEYAKRVSNRLGELFENRGAKKRENLYILRNTNPVAIQIESFFCDNVNDCNKANES
                     GYDYIARLITEGILNKDINM"
BASE COUNT          384 a           71 c          148 g          293 t
ORIGIN      
        1 taatatttaa aaaatataga tttatgataa aataagacaa atatgttaaa aaaatgataa
       61 tcacggagaa cttttacctt cttcaattaa tatattatta ttagtaataa ctttaaaatt
      121 atattactat tatataaaaa ttggcttaaa agaaggtgaa aaaagtaaat gaaaatatgc
      181 ataacagtag gtcatagtat actaaaaggt ggtaaaagta caggtgtaaa tggtatagtt
      241 gatgaataca attataataa aaaattagct cctatgttag ctgagatgct tataagtcaa
      301 ggtaatacag tagatgtaat aatttgtcca gaaaggcact ttatgtcaga aagagaagaa
      361 tttttctata gagttccaaa agtaaacagt ggtaaatacg atttattagt agagctacat
      421 ttaaataaag ctgatggaac acaatgtggt acagaagtgc tttactatgg cactgaagga
      481 ttagaatatg ctaaaagagt atctaataga cttggagaat tatttgaaaa tagaggagct
      541 aaaaaaagag aaaatttata tatattgaga aatacaaatc cagttgcaat acagattgaa
      601 agttttttct gtgataatgt gaatgattgt aacaaagcaa atgaatcagg ttatgattat
      661 atagcacgat tgattacaga aggtatattg aataaagata taaatatgtg agattatggt
      721 gatttaggta ttgattaata ccttttaata ttagatataa ataaaaatac aatgtattag
      781 tataatttaa actttcaaaa gatagattag tttgattatt gacaagagat acctccttga
      841 aaatattgat ttatcagtat atttaaggag gtatttaaat ataaaaattt aattaa
//
LOCUS       DAEQCW010000267          891 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.269, whole genome shotgun sequence.
ACCESSION   DAEQCW010000267 DAEQCW010000000
VERSION     DAEQCW010000267.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 891)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 891)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.269"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            370..840
                     /locus_tag="KRO40_003661"
     CDS             370..840
                     /locus_tag="KRO40_003661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBH2094452.1"
                     /translation="MKYQVSLLAVKDIEVSKKFYKELFEQEIELDLGKNVTFKGGFAI
                     QEDFAWLTGINPDTIIQKSNNMELYFEVDDFDEFIEKLNYYKDVEFVHKPLKHEWQQR
                     VVRIYDPDKHIIEIGESMEVIARRYLSEGYSVEETSKIIQHPIKFVKQCENSKE"
BASE COUNT          406 a           62 c          157 g          266 t
ORIGIN      
        1 taattaaaga gaatttttaa atataaattg tgaagcttta atatagatga taatatatat
       61 tttgcaaata tgacacagtg ttttcgtatt taagatgata aaataaatag gaattaatga
      121 tgatattgaa aaaataaaaa taaaggatta atataagata ttaaagagat agagataaaa
      181 gtgttaacag aagatattga aaaaataaaa gattgatata agatactgaa gaggtagaaa
      241 caaaagtgtt aatagaagat actaaaaaag taaaaataaa ggattaataa aaggtactga
      301 agagatagag aaaaaaatgt taatagaaga tactgaaaaa atagaaataa aaaattagga
      361 ggaaaattta tgaaatatca ggtttcatta ttagcagtga aggatattga agtatcaaaa
      421 aaattttaca aagaattatt tgagcaagaa attgaattgg acttaggtaa aaatgtaaca
      481 tttaaaggag gatttgctat acaagaagac ttcgcatggc ttacagggat taatccagat
      541 acaattatac aaaaatcaaa taatatggaa ctttattttg aggttgatga ttttgacgaa
      601 tttattgaaa aactcaatta ttataaagat gtagagtttg tccataagcc actaaaacat
      661 gaatggcaac aaagagtagt gcgtatttat gacccggata agcatattat tgagatagga
      721 gagtctatgg aagttatagc tagaagatat ttatctgagg gatactctgt agaagaaact
      781 tctaaaataa ttcaacatcc aattaaattt gtaaagcagt gtgaaaatag taaggaatga
      841 ttgtttaaat tataattatt tagtagaaat taattgtaat agaactaatt c
//
LOCUS       DAEQCW010000268          877 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.270, whole genome shotgun sequence.
ACCESSION   DAEQCW010000268 DAEQCW010000000
VERSION     DAEQCW010000268.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 877)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.270"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            33..866
                     /locus_tag="KRO40_003662"
     CDS             33..866
                     /locus_tag="KRO40_003662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prenyltransferase"
                     /protein_id="HBH2094453.1"
                     /translation="MNVENQSLSDIEIILSHRYDNGADYWTTPDKRLIKGSPFSTLDS
                     VLYLLELGVNPDDTLLKECADLIFSTWREDGRFKLYPNGGIYPCHTANAANVLCHMGY
                     ASDIKMQKTFQHFLDTQYTDGGWRCNKFSFGRGPETEYSNPLPTLNILNAFRFSNYLN
                     KESKLDKAVDFLLDHWTIKKPIGPCHYGIGTLFMQVEYPFRNYNLFLYVYVLSFYNRA
                     KKDNRFLEALKILESKMIGNKIVVERVVPKLSKLSFCKKGESSEIATTHYYEILKNLE
                     K"
BASE COUNT          317 a          133 c          140 g          287 t
ORIGIN      
        1 ttaatagaat ataatatgaa atggagtaaa aaatgaatgt agaaaatcaa tctttatcag
       61 atattgaaat aatattatca cacaggtatg ataatggtgc agactattgg actacacctg
      121 ataagcgttt aataaaaggt tctcctttct ctactcttga tagtgtactt tatctattag
      181 aattaggtgt gaaccctgat gatactttac ttaaagaatg tgctgacctg atatttagca
      241 catggcgaga agatggacgt ttcaaactat atccaaatgg aggtatttac ccttgtcata
      301 ctgcaaatgc tgctaacgta ctctgtcata tgggatatgc atctgacatt aaaatgcaaa
      361 aaacgtttca acatttttta gatacacagt atactgatgg tgggtggcgt tgcaataaat
      421 ttagttttgg tcgaggtcca gaaactgaat actcaaatcc actaccaact cttaatatat
      481 taaatgcatt ccgttttagt aattatctaa ataaagaatc aaaacttgac aaagctgtag
      541 attttctact tgaccattgg actattaaaa aaccaatcgg cccttgtcac tatggaattg
      601 gcacattatt tatgcaagtt gaatatcctt tccgtaatta taacctattc ctttatgtct
      661 acgttttatc attttataat cgtgcaaaaa aggataatag atttttagaa gcattgaaga
      721 tacttgaatc taaaatgata ggtaataaaa ttgtcgttga acgtgtagtt ccaaaactat
      781 ctaaattatc tttttgtaaa aaaggcgagt caagtgaaat agccacaaca cactattacg
      841 aaatattaaa aaacctagaa aaataatagt tatatag
//
LOCUS       DAEQCW010000269          812 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.271, whole genome shotgun sequence.
ACCESSION   DAEQCW010000269 DAEQCW010000000
VERSION     DAEQCW010000269.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 812)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.271"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            233..601
                     /locus_tag="KRO40_003663"
     CDS             233..601
                     /locus_tag="KRO40_003663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C-GCAxxG-C-C family protein"
                     /protein_id="HBH2094454.1"
                     /translation="MTRPSIYHSQGYTCAEALIKSYNEEHNTDIPISIGSGMGVGMNV
                     GSVCGAVNAAVVIIGYLNGRNSNLDENIARKYSRELLNRVRNKYSSEICVSLKKNKVT
                     CEEIINFTYDALNDMLKNQK"
BASE COUNT          353 a           66 c          126 g          267 t
ORIGIN      
        1 taagtcacag aaaatagagc taatttaata tataataaaa gcatgtcaag taaagcttta
       61 aattaaagta actttatata aaaagtaata taaattgata aaattataaa tttatttata
      121 gtgaatatag gttggatttt atagatacaa aaatagtata tatgatatgt agaccattag
      181 catgtttaaa gtagcaaaac atataaaata aaatttgaaa ggaagtataa aaatgacaag
      241 accatcaata tatcatagcc aaggatacac ttgtgcagag gcattaataa agtcttataa
      301 tgaggaacac aacacagata taccaatctc aataggaagt ggtatggggg ttggaatgaa
      361 tgttggaagt gtttgtggag ctgtaaatgc tgctgttgtt ataatagggt atttaaatgg
      421 gcgaaatagt aatttagatg aaaatatagc aaggaagtat tcaagagagc tattgaatag
      481 agtaagaaat aaatacagct cagaaatatg tgtatctctt aaaaaaaata aagtaacttg
      541 tgaagaaata ataaatttca catatgatgc tctaaatgat atgctaaaaa atcaaaaata
      601 attctaagaa acaagtattt tacattcgat agaatacttg tttttttatg atatttttaa
      661 taagtattag tttattataa tttttaaatc aattttatta tattttaatt gaaataatct
      721 actttgaaaa ttactaactg acaaaagaat atgattatag tatagaaaaa atgtaaatta
      781 tttaatatta agtgagagta tatgcttacc ta
//
LOCUS       DAEQCW010000270          786 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.272, whole genome shotgun sequence.
ACCESSION   DAEQCW010000270 DAEQCW010000000
VERSION     DAEQCW010000270.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 786)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 786)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.272"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            202..585
                     /locus_tag="KRO40_003664"
                     /pseudo
     CDS             202..585
                     /locus_tag="KRO40_003664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
BASE COUNT          360 a           64 c          128 g          234 t
ORIGIN      
        1 ttcaacagga ttgtttgaaa gttaaataaa tttatagata tgaacattat tttacactta
       61 aaaacaggat aaacacgtag agtacctggt aaaaattaaa tatagttttt gttctaaaaa
      121 gctcctatta taatttaagc tagataaatt tgaagaagtg acataagaag aagtgacata
      181 aattgaaaga aggaatatat tatgctaaat aaaaaattac cagatacaga attaaaaatt
      241 atgaaatgca tatggaatac tggttataaa actgtaatat caaaagatgt tgcagatgaa
      301 atagaaaaaa catatggttg gaagcataca actacaatta tacttttagc tagattaacc
      361 aaaaaaggtt ttttaatatc atagagaatt gggaggcatg tacactatac agtattaata
      421 aaagagagag aatatatcaa aatagaggaa aaaagagttt ttagaggttt acataacaat
      481 cctttatcag aattaatttc aaaattacat gatggagaag aaataactga agaaaaaata
      541 atagaaatag gaagttggat aaaaagctgg aaatatgaag attaataaat aaaaggtagc
      601 taataatata agagctacct tttttatgtg gataatactg gggataagtt gtggaaaact
      661 tatataaaaa ttgtggataa agtgttttgc tgacatttta ctgacaaaag ttaaaaaaat
      721 aaatgttata tatattgtaa aatgttgaaa aatagccata tatataaaat ataagtaaca
      781 ctatag
//
LOCUS       DAEQCW010000271          779 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.273, whole genome shotgun sequence.
ACCESSION   DAEQCW010000271 DAEQCW010000000
VERSION     DAEQCW010000271.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 779)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.273"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            101..760
                     /locus_tag="KRO40_003665"
     CDS             101..760
                     /locus_tag="KRO40_003665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBH2094455.1"
                     /translation="MLDAFITIVSSIIEIWSCKKVFDYTSQSKTDLKKLNMYFLFSVF
                     LIISSLYINIGANSRILICIFVMFVFYKSNYKVNIYKCLVISFFYWLILIGINGLSML
                     LVATVSNLDNMNVLLSGSLYRYEAIFLGKIMLGILLYVYKASFKNFKISKKEIYICIP
                     MIANLLSFFVLYDYIINLVKISPERRTAFLVIVLLLILSNISIFVLIHIILKIKIRKI
                     R"
BASE COUNT          279 a           62 c           97 g          341 t
ORIGIN      
        1 tatattaaat ttaagtgtgt tttttatgct ataattagta tgtatttttt atgatatatt
       61 ttataaaaaa tataatttaa tcatttttga ggatattatt atgttagatg catttataac
      121 aattgtttct tctattatag aaatatggtc atgtaaaaaa gtttttgatt atactagtca
      181 gtcaaagacc gacttaaaaa aactaaatat gtattttctc ttttctgttt ttctcattat
      241 ttcttcttta tatataaata taggagctaa tagtagaatc ttgatatgta tatttgtaat
      301 gttcgttttc tataagtcta actataaggt taatatatat aaatgtctgg taatctcatt
      361 tttttattgg ttaatattaa taggtataaa tggattaagt atgttattag tagcaacagt
      421 aagcaatttg gataatatga atgttttact tagtggcagt ttatatagat atgaagcaat
      481 attcttggga aagataatgt taggtatatt actttatgtt tataaggctt cttttaaaaa
      541 ttttaaaata agtaaaaaag agatatacat atgtattcct atgatagcaa atttattgtc
      601 attttttgta ctttatgatt atattattaa tcttgtaaaa atctctcctg aaagaagaac
      661 tgctttttta gtaatagttt tactattaat attatctaac atttcaatct ttgtattaat
      721 acatataata cttaagatta aaattaggaa aataagataa attttaatac gattcattt
//
LOCUS       DAEQCW010000272          753 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.274, whole genome shotgun sequence.
ACCESSION   DAEQCW010000272 DAEQCW010000000
VERSION     DAEQCW010000272.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 753)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.274"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>753
                     /locus_tag="KRO40_003666"
     rRNA            <1..>753
                     /locus_tag="KRO40_003666"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          207 a          156 c          227 g          163 t
ORIGIN      
        1 tttaactgag cgttcagtta cttgacgtag acccgaaacc gggcgaccta cccatgagca
       61 ggatgaagcg aaagtaaaat ttcgtggagg tccgaaccca cgagcgttga aaagctcggg
      121 gatgacttgt gggtagcggt gaaattccaa tcgagcccgg agatagctgg ttctccccga
      181 aatagcttta gggctagcct caaggtgaga gatacggagg tagagcactg aatgtcctag
      241 ggggtattgc acctaccgaa gactatcaaa ctccgaatgc cgtcatctta tacttgggag
      301 tcagactgtg ggtgataaga ttcatagtcg aaagggcaac agcccagatc gtcagctaag
      361 gtccctaaat gtaagttaag tggtaaagga tgtgggattg cacagacaac caggatgttg
      421 gcttagaagc agccactcat tcaaagagtg cgtaatagct cactggtcga gtgatcctgc
      481 gccgaagatt tccggggcta aaacttacta ccgaagctac ggcatcagta atgatgggta
      541 ggggagcttc ccatacgggt tgaagcatga ccgtaaggac atgtggacag tatgggagtg
      601 agaatgttgg catgagtagc gagatgtggg tgagaatccc acaggccgta aacccaaggt
      661 ttccagggga aggttcgtcc gccctgggtt agtcgggacc taagctgagg ccgaaaggcg
      721 taggtgatgg acaacaggtt gatattcctg tac
//
LOCUS       DAEQCW010000273          730 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.275, whole genome shotgun sequence.
ACCESSION   DAEQCW010000273 DAEQCW010000000
VERSION     DAEQCW010000273.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 730)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.275"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            191..523
                     /locus_tag="KRO40_003667"
     CDS             191..523
                     /locus_tag="KRO40_003667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HBH2094456.1"
                     /translation="MNTREMKEYRVFYNKKLSETDEFFRVFGSLDDKTYSEGAISKKN
                     KELMGLAISILSRCDECICYHIEGCINSGASKDEIIEAIKIGVIGGGSITYPNARFAI
                     KILEEFNI"
BASE COUNT          295 a           52 c          117 g          266 t
ORIGIN      
        1 agataggtaa taaagaaatt actaagattt ctattttagt tctgaaaaaa tcttacttat
       61 atgataactt attgagattt caaaaaataa tataaattag gctaatgaac ataaaatgaa
      121 aatttgtatt taatattgaa aatataagta cagtgtgata ttcttataag aaaaacatag
      181 gaggtagaag atgaatacta gagaaatgaa agaatatagg gtattttaca ataaaaaatt
      241 aagcgaaaca gatgagtttt ttagagtatt tggaagtctt gatgataaga cttattcaga
      301 aggggctata agtaaaaaaa ataaggaatt aatgggacta gctatttcaa ttttaagccg
      361 atgtgatgag tgtatttgtt atcatattga gggttgtatt aattctggag caagtaaaga
      421 tgaaattata gaagctataa aaataggtgt aattggtggc gggtctatta catatccaaa
      481 cgcaagattt gcaataaaaa ttttagaaga atttaatata taattttgat agacgtagtt
      541 tatttagact aataataata gtctatttaa gtctttgaaa ttaagcttta ttttctaagt
      601 tcacttctta ttaagttttt agaattgcat atataaatat aaatttttaa ataatatagt
      661 agttttaaat tatttacatc atagattgta ttgagaatag tatattgtca ttattaaatc
      721 ttttatacat
//
LOCUS       DAEQCW010000274          673 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.277, whole genome shotgun sequence.
ACCESSION   DAEQCW010000274 DAEQCW010000000
VERSION     DAEQCW010000274.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 673)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 673)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.277"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            52..>673
                     /locus_tag="KRO40_003668"
     CDS             52..>673
                     /locus_tag="KRO40_003668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3786 domain-containing protein"
                     /protein_id="HBH2094457.1"
                     /translation="MDEKITKNNYNVPFDYVRKKLKELDPHTISNLSNIPFNNDLNRF
                     TLNFFDRQYIIDYPSGEVWNSNGSLCNNFELKILIVRYLINAKGIPRTNKYVTFKEIP
                     GGNVYYPNFLNRTLYRLSEVFTSQIDKYKLVMEKIGAEKVNMGDLAYRFTYMGNTSMV
                     FILWFGDDEFPPNSNILFDSNIVYYFNAEDLAVVPDTAINAILNKIN"
BASE COUNT          263 a           75 c           98 g          237 t
ORIGIN      
        1 gaaaactttt tataaatata cttttaattg tttaaattgg aggaaaaaat tatggatgaa
       61 aagataacaa aaaataatta taatgttcca tttgactatg ttcgaaaaaa actcaaagaa
      121 ttagaccctc atacaattag taatttaagt aatatacctt tcaataatga tttaaataga
      181 ttcacactca atttttttga tagacaatat attatagact atccaagtgg agaagtttgg
      241 aatagtaatg gtagcctttg caataacttt gagcttaaaa tcttgatagt tagatattta
      301 atcaatgcta aaggtatccc tagaactaat aaatatgtaa cttttaaaga aataccagga
      361 ggcaatgttt attatccaaa ttttttaaac aggactctat ataggctttc agaagttttt
      421 acatctcaaa tagacaaata taagttagtt atggagaaaa ttggagctga aaaagtaaac
      481 atgggagatt tagcttatag gtttacatat atgggtaata catctatggt atttatactt
      541 tggtttggag atgatgaatt tcctccaaat tcaaatatat tatttgattc taatatagtt
      601 tattacttca atgcagaaga tttagcagtt gttcctgata cagctataaa tgcaatttta
      661 aataaaataa atc
//
LOCUS       DAEQCW010000275          671 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.278, whole genome shotgun sequence.
ACCESSION   DAEQCW010000275 DAEQCW010000000
VERSION     DAEQCW010000275.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 671)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.278"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..657)
                     /locus_tag="KRO40_003669"
     CDS             complement(<1..657)
                     /locus_tag="KRO40_003669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094458.1"
                     /translation="MENITSYFTTILCVFICLSSVFIFTQLARVFINKKKINQKIKSR
                     NGFRYDRDFIEARREEIHIKDNNNNKNKSNNKKLKEEKVFKYDNGDLYKGEFVDGKKN
                     GFGIYIFSGKEKYEGLWKDDKMHGIGKYTYRDGSIYTGEFKYGLKNGLGKLTYPNNDI
                     YKGYFLDNKKNGKGVLYKNDGNKQAGIWEDDEQCKSLDFKDLNNNKINNVYQNRLNNN
                     K"
BASE COUNT          206 a          119 c           37 g          309 t
ORIGIN      
        1 tttattgtta tttaatctat tttgataaac attatttatt ttattattat ttaaatcttt
       61 aaaatctaaa cttttacatt gttcatcatc ttcccatatt cctgcttgtt tatttccatc
      121 atttttatat aatacaccct taccattttt cttattatct aaaaaatatc ccttataaat
      181 gtcattattg ggatatgtta attttcccaa accatttttt aatccgtatt taaattcacc
      241 tgtatatatt gaaccatctc tataagtata ttttcctatt ccatgcatct tgtcatcttt
      301 ccataatcct tcatactttt ccttacctga aaaaatatat attccaaatc catttttctt
      361 tccatcaaca aactcacctt tatataaatc accattatcg tatttaaata ctttttcttc
      421 ctttaatttc ttattgttac tcttattttt attattattg ttatccttta tatgtatttc
      481 ttctcttctg gcttcaataa aatctctatc atacctaaat ccgtttcttg atttaatttt
      541 ttgattaatc ttcttcttat taataaatac tctagctagt tgagtaaata taaatacaga
      601 tgataagcat ataaatacac atagtattgt tgtaaaataa ctagttatat tttccataaa
      661 aaatcaccct t
//
LOCUS       DAEQCW010000276          665 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.279, whole genome shotgun sequence.
ACCESSION   DAEQCW010000276 DAEQCW010000000
VERSION     DAEQCW010000276.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 665)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 665)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.279"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            49..>665
                     /locus_tag="KRO40_003670"
     CDS             49..>665
                     /locus_tag="KRO40_003670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2094459.1"
                     /translation="MTLKYKCYDMPLNTTLNYNQSTGAYEGTINYNQDPEYLNVWELQ
                     GITINSKNNPKTLNRQDLEKLGLNLKDYNVTQECIIEDITSRKDVNKYLRKTSSPITE
                     LTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNV
                     PNSVKSELKRLNPKDIIIIGDENAISKTTANQIKSTVNASQTRLNG"
BASE COUNT          295 a           93 c          106 g          171 t
ORIGIN      
        1 aaatcaaaag ttagtgtcaa atttaaagaa aaaccagatg cagatagcat tacattaaag
       61 tataaatgct atgacatgcc attgaataca actctaaatt acaatcaatc aactggggca
      121 tatgaaggaa ctatcaatta taaccaagac ccagaatatc taaatgtttg ggaactacaa
      181 gggataacaa taaacagcaa aaataatcct aaaactttaa acagacaaga cctagaaaag
      241 ctgggattaa atttaaaaga ctataatgta acacaggaat gtataattga agatataact
      301 tctagaaaag atgtaaataa atatttgaga aaaacttctt cacctattac agaacttaca
      361 ggaagtgata gatatgaaac agcagttaaa ataagtaaag agggctggaa aaatggttca
      421 gataaggtag ttataataaa tggggatgta agtatagatg gcattatatc aactccactg
      481 gcaaccacat ataatgcacc aatacttttg gttgaaaaaa acaatgtacc taatagtgta
      541 aaatcagaat taaagcgcct aaaccctaaa gatataatta taattggaga tgagaatgct
      601 atttctaaaa ctactgctaa tcaaattaaa tcaactgtaa atgctagtca aacacgttta
      661 aatgg
//
LOCUS       DAEQCW010000277          665 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.280, whole genome shotgun sequence.
ACCESSION   DAEQCW010000277 DAEQCW010000000
VERSION     DAEQCW010000277.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 665)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 665)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.280"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            49..>665
                     /locus_tag="KRO40_003671"
     CDS             49..>665
                     /locus_tag="KRO40_003671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBH2094460.1"
                     /translation="MTLKYKCYDMPLDTTLNYNQSTESYEGTINYNKDPEYLNVWELQ
                     GITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRKDVNKYLRKTSAPITE
                     LTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNV
                     PNSVKSELKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKG"
BASE COUNT          294 a           87 c          109 g          175 t
ORIGIN      
        1 acctcaaaag tcagtgttaa gtttaaagaa aaaccagatg cagatagcat tacattaaag
       61 tataaatgct atgatatgcc attggataca actttaaact ataatcaatc aactgagtca
      121 tatgaaggaa ctatcaatta taataaagac ccagaatatc taaatgtttg ggaactacaa
      181 gggataacaa taaacagcaa aaataatcct aaaactttaa acaaacaaga actagaaaag
      241 atgggattaa atttaaaaga ctataatgta acgcaggaat gtataattga agatataact
      301 tctagaaaag atgtaaataa atatttaaga aaaacttctg cacctattac agaacttaca
      361 ggaagtgata gatacgaaac agcagttaaa ataagtaaag aaggctggaa aaatggttca
      421 gataaggtag ttataataaa tggggatgta agtatagatg gcattatatc aactccacta
      481 gcaactacat ataatgcgcc aatacttttg gttgaaaaaa acaatgtacc taatagtgta
      541 aaatcagaat taaagcgttt aaatcctaga gatgtaatta taattggaga tgagaatgct
      601 atttctaaaa ctactgctaa tcaaattaaa tcgactgtaa atgctagtca aacacgtcta
      661 aaggg
//
LOCUS       DAEQCW010000278          664 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.281, whole genome shotgun sequence.
ACCESSION   DAEQCW010000278 DAEQCW010000000
VERSION     DAEQCW010000278.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 664)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 664)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.281"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..>664)
                     /locus_tag="KRO40_003672"
     rRNA            complement(<1..>664)
                     /locus_tag="KRO40_003672"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          152 a          191 c          151 g          170 t
ORIGIN      
        1 gatccagccg caccttccga tacggctacc ttgttacgac ttcaccccag ttattgattc
       61 caccttcgac gacttcttcc aaaaggttag ataatcggct tcgggcgtct ccaactcccg
      121 tggtgtgacg ggcggtgtgt acaagacccg ggaacgcatt caccgcagca ttctgatctg
      181 cgattactag taactccagc ttcatgtagg cgagtttcag cctacaatcc gaactgagag
      241 tagctttaag ggattagctc caccttacgg cttggcaacc ctctgtacta cccattgtag
      301 cacgtgtgta gccctaagca taaggggcat gatgatttga cgtcatcccc accttcctcc
      361 aggttatccc tggcagtctc tctagagtgc ccaacttaat gatggcaact aaagacaagg
      421 gttgcgctcg ttgcgggact taacccaaca tctcacgaca cgagctgacg acaaccatgc
      481 accacctgtc accaatgtcc ccgaagggaa ctctccgatt aaggagatgt cattgggatg
      541 tcaagcttag gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc cgctacttgt
      601 gcgggtcccc gtcaattcct ttgagtttca ctcttgcgag cgtacttccc aggcggagta
      661 ctta
//
LOCUS       DAEQCW010000279          655 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.282, whole genome shotgun sequence.
ACCESSION   DAEQCW010000279 DAEQCW010000000
VERSION     DAEQCW010000279.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 655)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 655)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.282"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            145..588
                     /locus_tag="KRO40_003673"
     CDS             145..588
                     /locus_tag="KRO40_003673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBH2094461.1"
                     /translation="MIEIKTIEINKKSQIDLLMLADPCEEMIDKYLNKGTMYALYDNK
                     ELTCIAVVNEISKEICELKNIATYEHFQNMGYASKMIYHLLDVYSKKYSSMVVGTSES
                     GVPFYEKFGFVYSHKIKNFFVDNYPEPIFEGELQCVDMLYLSYNF"
BASE COUNT          266 a           58 c           96 g          235 t
ORIGIN      
        1 atattataat ttattattag tattaatatt ctagggaatt atcactatat tttaaaaagt
       61 aaaaatatat atcaaaatga actaaataag tactgtaaga agtttgttaa attaaggttt
      121 gaataaagtg agggtggaga acttatgata gaaataaaaa ctatagaaat aaataaaaaa
      181 agtcaaattg accttttaat gttagccgac ccatgtgaag aaatgattga taaatatctc
      241 aataaaggaa ctatgtacgc attgtatgat aataaagaac ttacttgtat agcagttgta
      301 aatgaaattt ccaaagaaat atgtgaatta aaaaacattg ctacatatga gcattttcaa
      361 aatatgggtt atgcctcaaa gatgatttat catcttttag atgtttatag taaaaaatat
      421 tcatcaatgg ttgttggtac atctgaaagc ggagttcctt tttatgagaa gtttggattt
      481 gtttattcac ataaaattaa aaactttttt gtagataatt atccagaacc aatctttgaa
      541 ggagaattac aatgtgttga catgttgtat ctatcatata acttttagat aggttaatat
      601 aattaattaa ttcatataat tatcggaatt ataatttata aattatgtat aataa
//
LOCUS       DAEQCW010000280          641 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.283, whole genome shotgun sequence.
ACCESSION   DAEQCW010000280 DAEQCW010000000
VERSION     DAEQCW010000280.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 641)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 641)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.283"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            8..84
                     /locus_tag="KRO40_003674"
     tRNA            8..84
                     /locus_tag="KRO40_003674"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:42..44,aa:Pro,seq:tgg)
     gene            170..245
                     /locus_tag="KRO40_003675"
     tRNA            170..245
                     /locus_tag="KRO40_003675"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:203..205,aa:Trp,seq:cca)
     gene            306..382
                     /locus_tag="KRO40_003676"
     tRNA            306..382
                     /locus_tag="KRO40_003676"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:340..342,aa:Pro,seq:tgg)
     gene            389..465
                     /locus_tag="KRO40_003677"
     tRNA            389..465
                     /locus_tag="KRO40_003677"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:423..425,aa:Ile,seq:gat)
     gene            469..544
                     /locus_tag="KRO40_003678"
     tRNA            469..544
                     /locus_tag="KRO40_003678"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:502..504,aa:Phe,seq:gaa)
     gene            552..628
                     /locus_tag="KRO40_003679"
     tRNA            552..628
                     /locus_tag="KRO40_003679"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:586..588,aa:Met,seq:cat)
BASE COUNT          150 a          146 c          185 g          160 t
ORIGIN      
        1 tcaaaaacga ggtgtagcgc agtttggtag cgcacatggt ttgggaccat ggggccgggg
       61 gttcgagtcc cttcacctcg accaacttaa gcttttagtt cagttggtta gagtgcccaa
      121 ctcatggcta gtaattctag ggtttgagtc catgaaggtt attcttcata ggggtgtagc
      181 tcagttggta gagcgtcggt ctccaaaacc gtgcgccggg ggttcgagtc cctccacccc
      241 tgccaaataa aaaggacttg aaaaaagttg gattttagag tagtataaga tagtaaataa
      301 gatttcgagg tgtagcgcag tttggtagcg cacatggttt gggaccatgg ggccgggggt
      361 tcgagtccct tcacctcgac caagaaaagg gcctatagct caggtggtta gagcgcacgc
      421 ctgataagcg tgaggtcgct ggttcgagtc cagctaggcc caccatttgc ccagatagct
      481 cagtcggtag agcaggggac tgaaaatccc cgtgtcggtg gttcgattcc gcctctgggc
      541 accaggaata cggcggtata gcttagttgg ctagagcgtt cggttcatac ccgaaaggtc
      601 ataggttcga ctcctattac cgctaccatc taactatatc a
//
LOCUS       DAEQCW010000281          587 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.284, whole genome shotgun sequence.
ACCESSION   DAEQCW010000281 DAEQCW010000000
VERSION     DAEQCW010000281.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 587)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 587)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.284"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..584
                     /locus_tag="KRO40_003680"
     CDS             <1..584
                     /locus_tag="KRO40_003680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2094462.1"
                     /translation="NREGRSIKQFRNKMYAYISKRLSKCKKGSRQSKKLWRLKNKIRS
                     KTDNQLMNLYHQTTRKFIDFCVEQKVCEIVLGDIKGVEKDTKKKKRLNRVNRQKISQM
                     EYGRIKDYIKYKAKEQGIEVKLVKENYTSQTCPKCSKKHKPTGRTYSCTCGYETHRDI
                     VGAWNILNKKHKYGLVDFRINHKQPINLKVSTV"
BASE COUNT          265 a           55 c          107 g          160 t
ORIGIN      
        1 ctaatagaga aggcagaagt attaaacaat ttagaaataa gatgtatgct tatatatcta
       61 aaagattaag taaatgtaaa aaaggtagta gacaatcaaa gaagttatgg agattaaaaa
      121 ataagataag aagtaaaaca gataatcagt taatgaattt atatcatcaa acaactagaa
      181 agtttataga cttttgtgta gagcagaagg tatgtgaaat agttcttggg gatataaaag
      241 gggttgaaaa agatactaag aaaaagaaaa gattaaacag agttaataga cagaaaatat
      301 ctcaaatgga gtatggtcga ataaaggact atataaaata taaagcaaaa gagcaaggta
      361 ttgaagttaa gttagttaaa gaaaactaca cttctcaaac ttgcccaaag tgttctaaaa
      421 aacacaaacc aactggtaga acttatagtt gtacttgtgg ttatgaaact catagagata
      481 tagttggtgc ttggaatatt ttaaataaaa agcataaata tggtttagta gattttagaa
      541 taaatcataa gcaaccaata aatttaaaag tatctaccgt ttgagcc
//
LOCUS       DAEQCW010000282          577 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.285, whole genome shotgun sequence.
ACCESSION   DAEQCW010000282 DAEQCW010000000
VERSION     DAEQCW010000282.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 577)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.285"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>577
                     /locus_tag="KRO40_003681"
     rRNA            <1..>577
                     /locus_tag="KRO40_003681"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          154 a          121 c          190 g          112 t
ORIGIN      
        1 caggatggac ccgcgtctga ttagctagtt ggtaaggtaa cggcttacca aggcgacgat
       61 cagtagccga cctgagaggg tgatcggcca cattggaact gagacacggt ccaaactcct
      121 acgggaggca gcagtgggga atattgcaca atgggcgaaa gcctgatgca gcaacgccgc
      181 gtgagtgatg aaggccttcg ggtcgtaaaa ctctgtcctc aaggaagata atgacggtac
      241 ttgaggagga agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggctag
      301 cgttatccgg atttactggg cgtaaagggt gcgtaggcgg tctttcaagt caggagtgaa
      361 aggctacggc tcaaccgtag taagctcttg aaactgggag acttgagtgc aggagaggag
      421 agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagttgcgaa
      481 ggcggctctc tggactgtaa ctgacgctga ggcacgaaag cgtggggagc aaacaggatt
      541 agataccctg gtagtccacg ctgtaaacga tgagtac
//
LOCUS       DAEQCW010000283          577 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.286, whole genome shotgun sequence.
ACCESSION   DAEQCW010000283 DAEQCW010000000
VERSION     DAEQCW010000283.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 577)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.286"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..>577)
                     /locus_tag="KRO40_003682"
     rRNA            complement(<1..>577)
                     /locus_tag="KRO40_003682"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          126 a          168 c          133 g          150 t
ORIGIN      
        1 gggggagata agcctgttat ccccagggta gcttttatcc gttgagcgat ggcccttcca
       61 cgcagaacca ccggatcact aagtccgatt ttcatccttg ctcgacctgt atgtcttgca
      121 atcaagctct cttttgcctt tacactctac gtacgatttc cgaccgtact gagagaacct
      181 ttgagcgcct ccgttacctt ttgggaggcg accgccccag tcaaactgcc cacctgacag
      241 tgtcccaaga ccagattcat ggcctatggt tagagtccca gtactacaag ggtggtatcc
      301 caaggatggc tccgccaaaa ctggcgtcct ggtttcaaag cctcccacct atcctgtaca
      361 tgtagtacca agacccaatg tcaagctaca gtaaagctcc atggggtctt tccgtcctgt
      421 cgcaggtatc cggcatcttc accggaatta caatttcacc gagtctgttg ttgagacagt
      481 gcccaaatcg ttacgccttt cgtgcgggtc ggaacttacc cgacaaggaa tttcgctacc
      541 ttaggaccgt tatagttacg gccgccgttt actgggg
//
LOCUS       DAEQCW010000284          573 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.287, whole genome shotgun sequence.
ACCESSION   DAEQCW010000284 DAEQCW010000000
VERSION     DAEQCW010000284.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 573)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 573)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.287"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>573
                     /gene="tuf"
                     /locus_tag="KRO40_003683"
     CDS             <1..>573
                     /gene="tuf"
                     /locus_tag="KRO40_003683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="EF-Tu; promotes GTP-dependent binding of
                     aminoacyl-tRNA to the A-site of ribosomes during protein
                     biosynthesis; when the tRNA anticodon matches the mRNA
                     codon, GTP hydrolysis results; the inactive EF-Tu-GDP
                     leaves the ribosome and release of GDP is promoted by
                     elongation factor Ts; many prokaryotes have two copies of
                     the gene encoding EF-Tu; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HBH2094463.1"
                     /translation="IPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLKVQDEV
                     ELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTGSVK
                     AHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNVT
                     MEVDLINSIVVEEGLRFSIREGGRTVASGV"
BASE COUNT          242 a           77 c          140 g          114 t
ORIGIN      
        1 atataccagc tccagagaga gatacagata aaccattctt aatgccagta gaggacgtat
       61 tctcaatcac aggaagagga acagttgcaa caggaagagt ggaaagagga gtactaaaag
      121 tacaagacga agtagaatta gtaggattaa cagaagcacc aagaaaagta gtagtaacag
      181 gagtagagat gttcagaaaa ttattagacc aagcacaagc aggtgataat ataggagcat
      241 tattaagagg agtacaaaga aacgagatag aaagaggaca agtactagca aagactggat
      301 cagtaaaggc acacacaaag tttacagcag aagtatatgt acttaaaaaa gaagagggtg
      361 gaagacatac accattcttt gatggatata gaccacaatt ctatttcaga acaacagacg
      421 taacaggagc ttgtaagtta ccagaaggaa tagagatggt aatgcctgga gataacgtaa
      481 caatggaagt agacttaata aactcaatag ttgtagaaga gggattaaga ttctcaataa
      541 gagaaggtgg aagaacagta gcttcaggag ttg
//
LOCUS       DAEQCW010000285          552 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.288, whole genome shotgun sequence.
ACCESSION   DAEQCW010000285 DAEQCW010000000
VERSION     DAEQCW010000285.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 552)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.288"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT          213 a           43 c           66 g          230 t
ORIGIN      
        1 tgagttgtaa aatattaaat aatattgtac taattggaat aattttaact ttattataga
       61 ttattttaat accattagta ctgatggtgt attttaaaat tggtataagc attacaaata
      121 cgaatatgcc aactgtaata tgtaatataa gtagctatat acatatgtgc tgtcccatat
      181 attgtatcat tgtttatatt aaaaagatta tgtaaattgg tatcaatcaa taaatcattt
      241 tcagaagaaa tacctaaaaa cttaaaaaat acctatatgt gtatttagtt agatttgaga
      301 tttttacatt taattttata gtgacaatat tatattattt ttatgatgtc tatttatatg
      361 caattactat aatatcagaa cttatagtat catttgtttc attatcaata aggtttttta
      421 ctttagtttt gtcaatttta ttaaaaaaag ttattgatat aaaagataag aaggataaaa
      481 ctatatgacg gatttcaaac ataagagtgg atatttatat aatagatatt ttatagttaa
      541 ttttattaga tt
//
LOCUS       DAEQCW010000286          520 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.289, whole genome shotgun sequence.
ACCESSION   DAEQCW010000286 DAEQCW010000000
VERSION     DAEQCW010000286.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 520)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.289"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            100..507
                     /gene="tnpA"
                     /locus_tag="KRO40_003684"
     CDS             100..507
                     /gene="tnpA"
                     /locus_tag="KRO40_003684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013824389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBH2094464.1"
                     /translation="MEVTHGRGYVYLVQYHIVWCVKYRHPVLTNEIEEDLINILNKIA
                     EDNKFQILECNSDKDHIHLLINCSPQHYIPDIIKALKGVSARLLMKKHGEQLKKKLWG
                     GHLWNPSYFVATVSENTEEQIRKYINNQKKQVK"
BASE COUNT          222 a           50 c           91 g          157 t
ORIGIN      
        1 ttgcgtttct tacgtatgtt atttaaaaat aaatataaaa accttaagaa tacttgtttt
       61 aagtaattac tatgttaata ttatgttggg tgatgaaaaa tggaagtgac tcatggtaga
      121 gggtatgtgt atttagtaca ataccatata gtatggtgtg taaaatatag acatccagta
      181 ttaacaaatg aaattgaaga agatttaatt aatatattaa acaaaatagc tgaagataat
      241 aaatttcaaa tattagaatg taatagtgat aaagatcaca tacatttact aataaattgt
      301 tcaccacaac actatatacc agatataata aaagcattaa aaggtgtatc agcaaggctg
      361 ttaatgaaaa aacatggaga acagttgaaa aagaaattat ggggaggaca tctttggaat
      421 cctagttatt tcgttgctac tgtatcagaa aatacagaag aacagataag aaaatatatt
      481 aataatcaga aaaaacaagt aaagtgaggt ggcagtagtg
//
LOCUS       DAEQCW010000287          497 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.290, whole genome shotgun sequence.
ACCESSION   DAEQCW010000287 DAEQCW010000000
VERSION     DAEQCW010000287.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 497)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.290"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            3..79
                     /locus_tag="KRO40_003685"
     tRNA            3..79
                     /locus_tag="KRO40_003685"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:37..39,aa:Asp,seq:gtc)
     gene            90..164
                     /locus_tag="KRO40_003686"
     tRNA            90..164
                     /locus_tag="KRO40_003686"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:122..124,aa:Gly,seq:gcc)
     gene            174..247
                     /locus_tag="KRO40_003687"
     tRNA            174..247
                     /locus_tag="KRO40_003687"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:208..210,aa:Arg,seq:tct)
BASE COUNT          156 a           83 c          105 g          153 t
ORIGIN      
        1 gcggcctggt agttcagttg gttagaatgc cagcctgtca cgctggaggt cgagggttcg
       61 agccccttcc aggtcgccaa attaaataag cgggaatagt tcagtggtag agcgcaacct
      121 tgccaaggtt gaagtcgcga gttcgaatct cgtttcccgc tccataataa cttgggtgca
      181 tagctcagct ggatagagca acgcccttct aaggcgtgtg tccggggttc gaatccctgt
      241 gcgctcatta agaaaagttt actataaatt atagtaaact tttatattgt ttaaaaagac
      301 acaggaaaca tgtatattac ctgtgtcttt ttatttataa actttaaact atgtaaaaat
      361 tacagtatat tctaatagag ttacagtata ttcattaata ttgtaaacat acggagggta
      421 atgtataata gtctacaaga tgtttatgaa ggcatcagtt aaatataata aatataacta
      481 attagtaaga gttatat
//
LOCUS       DAEQCW010000288          470 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.291, whole genome shotgun sequence.
ACCESSION   DAEQCW010000288 DAEQCW010000000
VERSION     DAEQCW010000288.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 470)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.291"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(161..460)
                     /locus_tag="KRO40_003688"
     CDS             complement(161..460)
                     /locus_tag="KRO40_003688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094465.1"
                     /translation="MKWIKWYSITCICIFIVVAFYMFIFPNKIETIDTSSAYSFVEKK
                     VPNSAVYQGYKKNPVDGTTTIYYSYDNSTHIVRLSHPEDYSRKINWDKVSNIRFD"
BASE COUNT          177 a           62 c           51 g          180 t
ORIGIN      
        1 ttttcaatat attttataaa ctaatatatt ttacaaattg ttaagtaata ttttatgata
       61 taaatcagaa gaggcacttc tataatagaa agtgctcaac tatgaataag attaataata
      121 tatttgcctt agatatatag acttttataa atattaaaga ttaatcaaat ctgatgtttg
      181 aaactttatc ccaattaatc ttccttgaat agtcttctgg atgtgataat ctaactatat
      241 gagttgaatt atcatagctg taataaattg tagtagtacc atcaactgga ttctttttgt
      301 atccttgata cacagcacta tttggtactt tcttttcaac aaagctatat gcagatgaag
      361 tatcaatagt ttctatttta ttaggaaata taaacatata aaaagctact actataaaaa
      421 tacatatgca tgtaatacta taccatttaa tccatttcat aaaattcctc
//
LOCUS       DAEQCW010000289          436 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.292, whole genome shotgun sequence.
ACCESSION   DAEQCW010000289 DAEQCW010000000
VERSION     DAEQCW010000289.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 436)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.292"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT          206 a           28 c           42 g          160 t
ORIGIN      
        1 gtacattatt tattttagaa aaaagataat tatctaatta tatttaagga taataatatg
       61 aaaataattt ttatattaaa aaatatgaat gaaaatagtg ggttttataa aaaaacatat
      121 ttagatttta acatctcaaa ggagttttca aagctaatat ttcattttta aataaaaaaa
      181 taaaatatta gttttgattt ctggtttaaa ttgggttata ataaattgtc aaattattta
      241 ttaatataaa atagactata aaacaagcaa aaatcatact attatataaa agaccttaaa
      301 gatagaaaac tacagaaaga agccaaaatg tttttgaaaa aaatgaaatt ttattgcaaa
      361 aaaatcaaaa tgaatttaac ttaatagtta taatctattt ttagtgttat aaatatacaa
      421 tgtatattat acaata
//
LOCUS       DAEQCW010000290          404 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.293, whole genome shotgun sequence.
ACCESSION   DAEQCW010000290 DAEQCW010000000
VERSION     DAEQCW010000290.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 404)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 404)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.293"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            119..235
                     /gene="rrf"
                     /locus_tag="KRO40_003689"
     rRNA            119..235
                     /gene="rrf"
                     /locus_tag="KRO40_003689"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            242..316
                     /locus_tag="KRO40_003690"
     tRNA            242..316
                     /locus_tag="KRO40_003690"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:274..276,aa:Asn,seq:gtt)
     gene            321..395
                     /locus_tag="KRO40_003691"
     tRNA            321..395
                     /locus_tag="KRO40_003691"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:354..356,aa:Glu,seq:ttc)
BASE COUNT          128 a           76 c           96 g          104 t
ORIGIN      
        1 attcattaag atatatgtgc agtttttaga gtgttaactc taaaaaaaaa taaaaaaagt
       61 attgacaaaa atagtaaaaa atgttaatat tatacttgtc ctagcaacaa gaaaaaaatg
      121 tggttataat agcggagaag atacacctgt ttccattccg aacacagaag ttaagttctc
      181 tagcactgat ggtacttggt gggaaactgc ctgggagagt aggacatagc cacgtgaatg
      241 ttccaaggta gctcaacggt ggagcaaccg gctgttaacc ggtaggctgt gggttcgagc
      301 cccacccttg gagccattat ggctcgttgg tcaagaggtt aagacaccgc cctttcacgg
      361 cggtaacagg ggttcaattc ccctacgagt caccatttgt ggga
//
LOCUS       DAEQCW010000291          390 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.294, whole genome shotgun sequence.
ACCESSION   DAEQCW010000291 DAEQCW010000000
VERSION     DAEQCW010000291.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 390)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 390)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.294"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT          169 a           34 c           38 g          149 t
ORIGIN      
        1 ttaaaatttt atttatatat ctttcattat ggttatatac aatatttgaa ttgtcattaa
       61 atatgccaat agttttatat attattgatt ttattaaaaa aagagatata caaactaata
      121 agttgtaatc tctcaaatat aaaaaaacaa taaattagct cattggattt tttagtccat
      181 aatataatta tagattattc accaaacaat ctatagaaat tgtggtatta atgtttaaat
      241 aaccaacttt ttctaaaata acctttatag gaatatatga gttcataagt aaagatagcg
      301 aaataagaaa ccagtttggt atgtaaaatc tagattttta attaaattat caagattata
      361 tattatagta tcaaaaatag aaaattaaaa
//
LOCUS       DAEQCW010000292          376 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.295, whole genome shotgun sequence.
ACCESSION   DAEQCW010000292 DAEQCW010000000
VERSION     DAEQCW010000292.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 376)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.295"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..294)
                     /locus_tag="KRO40_003692"
     rRNA            complement(<1..294)
                     /locus_tag="KRO40_003692"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          103 a           88 c           60 g          125 t
ORIGIN      
        1 ccaataaaga aaactttatt ggtttgggct aatccgcgtt cgctcgccgc tacttacgga
       61 atcgaatttc tttctcttcc ttcaggtact tagatgtttc agttccctga gttcccctca
      121 ttaagctatg tattcactta atgatactta gacattactc taagtgagtt tcctcattcg
      181 gaaatcttcg gatcaaagtt tacgtgcaac tccccgaagc ttatcgcagc ttatcacgtc
      241 cttcatcggc tcctagtgcc aaggcatccg ccctgcaccc ttaataactt gaccagttaa
      301 aaaggtttga tagattagaa gctatcaact tcgataattt taaaaagtta tcagctttat
      361 atattacaaa ttagat
//
LOCUS       DAEQCW010000293          368 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.296, whole genome shotgun sequence.
ACCESSION   DAEQCW010000293 DAEQCW010000000
VERSION     DAEQCW010000293.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 368)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 368)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.296"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..>368)
                     /locus_tag="KRO40_003693"
     rRNA            complement(<1..>368)
                     /locus_tag="KRO40_003693"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT           86 a          108 c           79 g           95 t
ORIGIN      
        1 ctattagtat cgataagcta aatacattgc tgcacttaca ccttcgacct atcaaccaga
       61 tagtctttct ggggtcttac ccttgcggtg ggaaatctta tcttgaagtt ggcttcgcgc
      121 ttagatgctt tcagcgctta tccattccgt acatagctac ccagccatgc ccttggcagg
      181 acaactggta caccagaggt acgtccatcc cggtcctctc gtactaagga caggtcttct
      241 caaatttcct acgcctgcga cggataggga ccgaactgtc tcacgacgtt ctgaacccag
      301 ctcgcgtacc actttaatgg gcgaacagcc caacccttgg gacctactac agccccagga
      361 tgtgatga
//
LOCUS       DAEQCW010000294          363 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.297, whole genome shotgun sequence.
ACCESSION   DAEQCW010000294 DAEQCW010000000
VERSION     DAEQCW010000294.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 363)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 363)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.297"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            167..283
                     /gene="rrf"
                     /locus_tag="KRO40_003694"
     rRNA            167..283
                     /gene="rrf"
                     /locus_tag="KRO40_003694"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            290..361
                     /locus_tag="KRO40_003695"
     tRNA            290..361
                     /locus_tag="KRO40_003695"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:322..324,aa:Asn,seq:gtt)
BASE COUNT          116 a           61 c           78 g          108 t
ORIGIN      
        1 ttcattaaga tatatgtgca gtttttagag tgttaactct atgtaaagta ctaacttcaa
       61 ttgatgaagt atatatcgta aaaacaatta ctatttagta cttcaaaact attgacattt
      121 aaaaataaag atgttaatat aatacttgtc ttataaatag gcaatatgtg gttataatag
      181 caaagaggat acacctgttc ccattccgaa cacagaagtt aagctcttta gcgctgatgg
      241 tacttggtgg gaaactgcct gggagagtag gacgtagcca cgtgaatatt ccaaggtagc
      301 tcaatggtgg agcaaccggc tgttaaccgg taggctgtgg gttcgagccc cacccttgga
      361 gcc
//
LOCUS       DAEQCW010000295          341 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.298, whole genome shotgun sequence.
ACCESSION   DAEQCW010000295 DAEQCW010000000
VERSION     DAEQCW010000295.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 341)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.298"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            12..88
                     /locus_tag="KRO40_003696"
     tRNA            12..88
                     /locus_tag="KRO40_003696"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:46..48,aa:Pro,seq:tgg)
     gene            96..172
                     /locus_tag="KRO40_003697"
     tRNA            96..172
                     /locus_tag="KRO40_003697"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:130..132,aa:His,seq:gtg)
     gene            181..256
                     /locus_tag="KRO40_003698"
     tRNA            181..256
                     /locus_tag="KRO40_003698"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:214..216,aa:Lys,seq:ttt)
     gene            264..337
                     /locus_tag="KRO40_003699"
     tRNA            264..337
                     /locus_tag="KRO40_003699"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:296..298,aa:Cys,seq:gca)
BASE COUNT           78 a           79 c           96 g           88 t
ORIGIN      
        1 taatataaat tcgaggtgta gcgcagtttg gtagcgcaca tggtttggga ccatggggcc
       61 gggggttcga gtcccttcac ctcgaccaat ataaggtggg tatagctcag ttggttagag
      121 cgccagattg tggctctgga ggtcgtgagt tcgactctca ttatccaccc caattcatat
      181 ggtctattag ctcagtcggt agagcacctg acttttaatc agggtgtccc gcgttcgagt
      241 cgcggataga tcaccaaaaa ggtggcgaca tagccaagtg gtaaggcagt ggactgcaac
      301 tccttgatcc ccagttcgaa tctgggtgtc gcctccaaaa t
//
LOCUS       DAEQCW010000296          327 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.299, whole genome shotgun sequence.
ACCESSION   DAEQCW010000296 DAEQCW010000000
VERSION     DAEQCW010000296.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 327)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.299"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT          131 a           25 c           31 g          140 t
ORIGIN      
        1 tataaataat aaaattaatt ttactatcta cccatatatt tagttatatt gcaggcagaa
       61 tgtggtttac cataaccaaa aggacaataa aaaatatttt tctatatttt tattatcttt
      121 ttgtaaaaga tttattattt attgcattaa attaataggc agtagaggca tagttgataa
      181 aattaatgaa gaaattaaac ttatgaatat aaatttatta ttgagtttta atattacatt
      241 tattattctc tttgatttta atattttata tttaataatt attacattcg tctggttaat
      301 aaataataat taaataaatc aaatgat
//
LOCUS       DAEQCW010000297          315 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.300, whole genome shotgun sequence.
ACCESSION   DAEQCW010000297 DAEQCW010000000
VERSION     DAEQCW010000297.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 315)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 315)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.300"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>315
                     /locus_tag="KRO40_003700"
     CDS             <1..>315
                     /locus_tag="KRO40_003700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2094466.1"
                     /translation="RILNATISKEPSGRYYVSLCCTDVDIEAFENTNNHIGLDLGIKE
                     FCISSCGEFIENPKYLKKSLNKLAKLQRELSRKTIGSLNRNKARLEVAGLQEHIANQR
                     KDF"
BASE COUNT          131 a           32 c           55 g           97 t
ORIGIN      
        1 agaatactta atgctactat atctaaagag ccaagtggta gatattatgt atcattatgc
       61 tgtactgatg tagatattga agcatttgaa aatactaata atcatatagg tttagattta
      121 ggaattaaag aattttgtat ctcaagttgt ggagaattta tagaaaatcc taagtatctt
      181 aagaagtcat taaacaagct tgctaaatta caaagagaat tatcgagaaa aacaatcggt
      241 agtttaaata gaaataaagc aagattagaa gttgcaggac ttcaagaaca tatagctaat
      301 caaagaaagg atttt
//
LOCUS       DAEQCW010000298          307 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.301, whole genome shotgun sequence.
ACCESSION   DAEQCW010000298 DAEQCW010000000
VERSION     DAEQCW010000298.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 307)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.301"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            39..>307
                     /locus_tag="KRO40_003701"
     CDS             39..>307
                     /locus_tag="KRO40_003701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBH2094467.1"
                     /translation="MFPIKYINNNLVWNKDNEVFAYYELIPYNYSFLSAEQKFIVHDS
                     FRQLIAQSREGKIHALQIATESSIRSMQEQSKKLVTGKLKEVAYQ"
BASE COUNT          104 a           63 c           65 g           75 t
ORIGIN      
        1 actcaatgaa acaatcacgg cagtaaggag tgtgaactat gttcccgata aaatatatta
       61 acaataacct tgtctggaac aaggacaatg aggtattcgc ctactatgag ctgataccgt
      121 acaactattc tttcttatcc gcagagcaga aatttatcgt gcatgacagt ttccgacagc
      181 ttatcgcaca gtcccgtgag ggtaaaattc atgcgttgca gattgccaca gaaagctcaa
      241 tccgcagtat gcaggaacag tcaaagaagc tggtaactgg aaaattaaag gaagttgcct
      301 atcagaa
//
LOCUS       DAEQCW010000299          307 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.302, whole genome shotgun sequence.
ACCESSION   DAEQCW010000299 DAEQCW010000000
VERSION     DAEQCW010000299.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 307)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.302"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            39..>307
                     /locus_tag="KRO40_003702"
     CDS             39..>307
                     /locus_tag="KRO40_003702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP/GTP-binding protein"
                     /protein_id="HBH2094468.1"
                     /translation="MFPIKYIDNNLVWNKDNEVFAYYELIPYNYSFLSAEQKFIVHDS
                     FRQLIAQSREGKIHALQIATESSIRSMQEQSKKLVTGKLREVAVQ"
BASE COUNT          101 a           62 c           71 g           73 t
ORIGIN      
        1 cttgaatgaa acaatcacgg cagtaaggag tgtgaactat gttcccgata aaatatattg
       61 acaataacct tgtctggaac aaggacaatg aggtgttcgc ctactatgag ctgataccat
      121 acaattattc tttcctatcc gcagagcaga aatttatcgt gcatgacagc tttcgacagc
      181 taatcgcaca gtcccgtgag ggtaaaattc atgcgttgca gattgccaca gaaagctcaa
      241 tacgaagtat gcaggagcag tcaaagaaac tggtaacggg gaaacttcgt gaggtggcag
      301 tccaaaa
//
LOCUS       DAEQCW010000300          291 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.303, whole genome shotgun sequence.
ACCESSION   DAEQCW010000300 DAEQCW010000000
VERSION     DAEQCW010000300.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 291)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.303"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..>291)
                     /locus_tag="KRO40_003703"
     rRNA            complement(<1..>291)
                     /locus_tag="KRO40_003703"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT           57 a           78 c           62 g           94 t
ORIGIN      
        1 ctacttaacg taactcgttg gcccgttcta caaaaagtac gcggtcacac aagaaatgtg
       61 cttccacagc ttgtaagtgc agggtttcag gttctatttc actcccctcc cggggttctt
      121 ttcacctttc cctcacggta ctatacgcta tcggtcacta ggtagtattt agccttggag
      181 ggtggtccct cctgcttccc acagggtttc acgtgtcccg tggtactctg gatcatatct
      241 aaagtcttct cgtttaacat acaggactat taccttctgt ggtgggtctt t
//
LOCUS       DAEQCW010000301          289 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.304, whole genome shotgun sequence.
ACCESSION   DAEQCW010000301 DAEQCW010000000
VERSION     DAEQCW010000301.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 289)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.304"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            <1..>289
                     /locus_tag="KRO40_003704"
     CDS             <1..>289
                     /locus_tag="KRO40_003704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBH2094469.1"
                     /translation="IKLPKLGMVKVRDKQVPQGRILNATISKEPSGRYYVSLCCTNVD
                     IEVFENTNNQIGLDLGIKEFCISSCGDFIENPKYLKKSLNKLAKLQRELSR"
BASE COUNT          118 a           31 c           49 g           91 t
ORIGIN      
        1 atataaaact acctaaactt ggtatggtta aggtaaggga taaacaagta cctcaaggta
       61 gaatacttaa tgctactata tctaaagaac caagtggtag atattatgta tcattatgct
      121 gtactaatgt agatattgaa gtatttgaaa atactaataa tcagataggt ttagatttag
      181 gaattaaaga attttgtatc tcaagttgtg gagactttat agaaaatcct aagtatctta
      241 agaagtcatt aaacaaactt gctaaattac aaagagaatt atcgagaaa
//
LOCUS       DAEQCW010000302          271 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.305, whole genome shotgun sequence.
ACCESSION   DAEQCW010000302 DAEQCW010000000
VERSION     DAEQCW010000302.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 271)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 271)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.305"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT           90 a           32 c           15 g          134 t
ORIGIN      
        1 gaaaagttat cttaaataaa aaataagtgt atcttaaatt ttaaatgata cacttatttt
       61 tatattgaaa ttatattttt taatatctat tcttaattag gtatttttaa attatctgtt
      121 tacattaaat atttcttaat tacttatctt tcagctagct ttttctatta aatgtttctc
      181 aattacttat ttttcaatta gccacttcta ttaagcattt cttaattact tatttttcaa
      241 ttagtcactt ctattaaaca tttcttaatt a
//
LOCUS       DAEQCW010000303          232 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.307, whole genome shotgun sequence.
ACCESSION   DAEQCW010000303 DAEQCW010000000
VERSION     DAEQCW010000303.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 232)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 232)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.307"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..>232)
                     /locus_tag="KRO40_003705"
     CDS             complement(<1..>232)
                     /locus_tag="KRO40_003705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002590471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="peptidase dimerization domain-containing
                     protein"
                     /protein_id="HBH2094470.1"
                     /translation="NVIQKIQQLVPPTHPVLGDGILVLTDIKSSPYPGASVVPDYCKA
                     TFDRRLLVGETREGVLAPIQALLDEMMKEDPE"
BASE COUNT           66 a           41 c           37 g           88 t
ORIGIN      
        1 aattctgggt cttctttcat catttcatct aataaagctt gtattggagc taatacgcct
       61 tctcttgttt ctccaactaa taatcttcta tcaaaagtag ctttgcaata atctggcact
      121 actgatgctc ctggatatgg agaagatttt atatctgtta aaactaatat tccatcacct
      181 aaaactggat gagttggagg tactaattgt tgtatctttt ggattacatt ag
//
LOCUS       DAEQCW010000304          232 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.308, whole genome shotgun sequence.
ACCESSION   DAEQCW010000304 DAEQCW010000000
VERSION     DAEQCW010000304.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 232)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 232)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.308"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
BASE COUNT          113 a           26 c           18 g           75 t
ORIGIN      
        1 ttatataaat tttaatagaa tatgtatagt atatagtaga tagaatgtat aaaaataaaa
       61 actgttcaat aagaattaat atacattaat tcagctgaat ccaatcaaaa tacttaaata
      121 aaagtaatct gaaaataaca taattcaaat caatttattc aaataaacct caatttatct
      181 caaatcttaa gaagtcatta aacaaacttg ctaaattaca aagagaatta tc
//
LOCUS       DAEQCW010000305          209 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.310, whole genome shotgun sequence.
ACCESSION   DAEQCW010000305 DAEQCW010000000
VERSION     DAEQCW010000305.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 209)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 209)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.310"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            73..>209
                     /locus_tag="KRO40_003706"
     CDS             73..>209
                     /locus_tag="KRO40_003706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBH2094471.1"
                     /translation="MLQIKNLSKSFPNPYGEPNTIFENLSIDIEDGEFVSIIGSNGTG
                     KS"
BASE COUNT           91 a           25 c           32 g           61 t
ORIGIN      
        1 taaatatttc actaaaaaaa aacaaatgca aagctagtac caaaaataaa tcagaaaaaa
       61 gaggtgttgt agatgttaca aattaaaaat ctttcaaaga gtttccctaa tccatatggt
      121 gaacctaata ctatctttga aaatttatca atcgatatag aagatggtga atttgtaagt
      181 atcataggta gtaatggaac tggtaaatc
//
LOCUS       DAEQCW010000306          206 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.denovo.311, whole genome shotgun sequence.
ACCESSION   DAEQCW010000306 DAEQCW010000000
VERSION     DAEQCW010000306.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 206)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 206)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.denovo.311"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            complement(<1..167)
                     /locus_tag="KRO40_003707"
     rRNA            complement(<1..167)
                     /locus_tag="KRO40_003707"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT           52 a           55 c           39 g           60 t
ORIGIN      
        1 ttatcccgta ttagcatacc tttcggtatg ttatccgtgt gtacagggta ggttacccac
       61 gcgttactca cccgtccgcc gctctttacc gaagtaaatc gctcaacttg catgtgttag
      121 gcacgccgcc agcgttcatc ctgagccagg atcaaactct caaataaaag tttatcaggc
      181 tcagatacta ttgttatcaa aatatc
//
LOCUS       DAEQCW010000307        16276 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.guided.083, whole genome shotgun sequence.
ACCESSION   DAEQCW010000307 DAEQCW010000000
VERSION     DAEQCW010000307.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16276)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16276)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16276
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.guided.083"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            247..864
                     /locus_tag="KRO40_003708"
     CDS             247..864
                     /locus_tag="KRO40_003708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HBH2094472.1"
                     /translation="MCKKTYLLVVSILIAGLLTACSGSPTTDSGQAQDNTKKEANASN
                     NALKDEKNNENLMEQDFKVPYTDAINIFKDKYKDADIVDLSLERDLNKFVYTVEGVDD
                     NNEYKMKIDANTKDVLEDKTEKLDSEDLNGVARKEKLDLNDIMTPQQAMEIALKEQNG
                     IVKEWSLDKDLDVTFYKIRIDKDKNEYDIKVDSKKGTVLKVEKED"
     gene            972..3503
                     /locus_tag="KRO40_003709"
     CDS             972..3503
                     /locus_tag="KRO40_003709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBH2094473.1"
                     /translation="MSLKSLKIKENLYWVGSLDPDLRVFDIIMYTPYGTTYNSYVLKG
                     TEKTVLFETVKDKHFDNYIERLNDLNIDFEKIDYIVVSHTEPDHAGSVEKLLDLAKNA
                     KVVASETAIKYLKEIVNKDFEYVAVTDGDTLSIGDKTLEFFSVPMLHWPDTIYTYIKE
                     DKTLVTCDSFGSHYSNDKIVNTLDENEEKDYLDALRYYYDCIMGPFKPSMVTAIEKIK
                     DLDIDTVCPGHGPVLTENPRKIIDLYYNWSVNEQIKLEKEVTICYVSAHGYTKIMAEA
                     IKAYIEKNSNYKVNLFDVIEHKQEDILAKIAVSQGVLFGTPTILGDALKPIWDILISL
                     NPVLHGGKVASVFGSYGWSGEGIENAMERISQLRMTAVKPFAVNFKPSNEEIDKLHSY
                     TGKFLDKLNSTFGSKKKTKKFKCVICNEVFEGDSAPSVCPVCGAKEDQFIEVEEDEVT
                     FRKDTDEYFVIVGNGAAGFYAADAIRKRNKTCKITMISNEDELTYYRPALSDGINEEL
                     GSDFYMEDKDWYDKNNIVVILGTNVDKLDEVNKTIIVNDGAIKFDKLVIATGSRNFIP
                     PIKGHDLENVFTLRNIKDLYSVKEALEKSKKVVVIGGGLLGLEAAWEFRLKGLEVVVV
                     EAMDSILSKQLDKEGSKILEQCVRDTGIDVRLGVAVDGIEGDGKAQKVVFKDGDSVDC
                     DMVVFSIGVRANTQMVQDTSVKIDRGIVVDKTLQTNVKDIYACGDVAQVGNISLAIWP
                     SSVEMGKIAGANASGDNLTFESEVYPVSLDAMNVKVFSIGNIQNFDKEISSKDEGQRI
                     YKKLFMKDGSLVGAILINDLSCTVKLIRLISEKGDFEDIMKADIL"
     gene            3937..4638
                     /locus_tag="KRO40_003710"
     CDS             3937..4638
                     /locus_tag="KRO40_003710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBH2094474.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
     gene            4688..5770
                     /locus_tag="KRO40_003711"
     CDS             4688..5770
                     /locus_tag="KRO40_003711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBH2094475.1"
                     /translation="MRTALMAFIAIIFIWILYSFILYGKFSIWIVSFFENAFRMEYKA
                     ALNLYQQIFRNSMELFMILAMVIVFFIIFRVYLNWFTKYFSEINQGIDSLIKEDVGEV
                     ALSPELLAIEKKINSIKHILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTL
                     LRDESQISEELRKKYLSISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLE
                     QLTYEFKPTLMSKNLKYTLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEIT
                     AVQEDDYIKLKFMNHSNTIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVEL
                     HNGTITAHSENNIITFKVIIPIVGNL"
     gene            6031..7131
                     /gene="vanG"
                     /locus_tag="KRO40_003712"
     CDS             6031..7131
                     /gene="vanG"
                     /locus_tag="KRO40_003712"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBH2094476.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNDDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            7128..7934
                     /locus_tag="KRO40_003713"
     CDS             7128..7934
                     /locus_tag="KRO40_003713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBH2094477.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            7952..10090
                     /gene="vanT"
                     /locus_tag="KRO40_003714"
     CDS             7952..10090
                     /gene="vanT"
                     /locus_tag="KRO40_003714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBH2094478.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKHLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVNMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINDCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLAE
                     LSASEVANNSCSISNELLSRVGRRLNVIKK"
     gene            10404..11024
                     /locus_tag="KRO40_003715"
     CDS             10404..11024
                     /locus_tag="KRO40_003715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBH2094479.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
     gene            complement(11190..11726)
                     /locus_tag="KRO40_003716"
     CDS             complement(11190..11726)
                     /locus_tag="KRO40_003716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBH2094480.1"
                     /translation="MIKETHERGGYIFALLILPFINNLYLVKYDIAYKIVLIIIYIYF
                     AYLGSLFPDIDMRGSYISKKFMLIYKLFGSRFRHRGFTHSLIALLLIYSFFKSLTIFT
                     NNNIVFSCLSSGFIIGYLSHLCLDLITKEGIELFYPITINISLLPIKTNSKTEKFISK
                     LLNFIVIFLIGYQFYILL"
     gene            complement(11839..12513)
                     /locus_tag="KRO40_003717"
     CDS             complement(11839..12513)
                     /locus_tag="KRO40_003717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HBH2094481.1"
                     /translation="MSLFIISQCITSFAFTPENNKFKVKPLPYAYDALEPYIDKETMK
                     LHHDKHYQAYVDKLNAALEKYPELYNYSLCELLQNLDSLPKDIATTVRNNAGGAYNHK
                     FFFDIMTPEKTIPSESLKEAIDRDFGSFEKFKQEFQKSALDVFGSGWAWLIATKDGKL
                     SIMTTPNQDSPVSKNLTPIIGLDVWEHAYYLKYQNRRNEYIDNWFNVVNWNGALENYK
                     NLKSQD"
     gene            12716..14590
                     /gene="asnB"
                     /locus_tag="KRO40_003718"
     CDS             12716..14590
                     /gene="asnB"
                     /locus_tag="KRO40_003718"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBH2094482.1"
                     /translation="MDGNISIYYKGDISKKEDIKFKIKESVNNTRLSSRIEYKDEEKT
                     FDFERFNVIDAIYGNKPFEKDGKVIVFNGNIYNYHEIKEELIKKGHNFTTNDDIEVLL
                     ASYIEFGKNCVHKIKGMFNFIIYDRENESIFGARDLFGIKPLYYINKENAIIFSSEYK
                     FLLEYMKNLNINERSLQSYFSFQYVLPEDTMIQGIRLIPAGHYFRVENGILSLKRYNK
                     LEFRSSTKFFYTKNHLGNRDVNEDDIRNIVVDSIVTHMEEEKEIGTFLSGGIDSSIIT
                     TVASQINPNIKSFSAGFSVKGYSELEVAKKTADKLGIENIQINITQDEYIKSLPNVIY
                     SLDDPIADPSEVGLYFLIKEAGKHVKVALSGEGADELFGGYNIYKEYSTMKSVVNSPT
                     YIKSILGRVSELMPNIKGRNYLYRATTPLEKRYIGNAKVFENSEVKRFFFKYKEKNIY
                     EYLLSNLYRDAQKNNYDYISKMQHIDVNTWLQGDILQKISKLSTAEQVELRVPFLYKD
                     VFDVAKNLRMEQKINKNNTKVLLREAFREIVPEHVVQRKKLGFPTPIRVWLKDSLGDI
                     VKETIYNSNVDEFIDKKYAIKLLDTHLKGHRDNSRKIWTIFTFCLWHQLFIEHKNVEY
                     "
     gene            complement(14682..16118)
                     /locus_tag="KRO40_003719"
     CDS             complement(14682..16118)
                     /locus_tag="KRO40_003719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBH2094483.1"
                     /translation="MICTIKPLKISIKKSTEPLIEFISDTTYKNKSSSYIKEVYFTRY
                     IGVDDSIDKYIEKIKNIDTYFFNNPTIPYIRLNNLKINFDKEQTDKMLKIFNIYNSSK
                     FNSWDLYNIDFPCKIENDTLNWTKKIAFKNTLDLFSTSMPNCTSSIIKNFAVKLLCWI
                     DYFLPKLFYNKVKTTISPKIVYFGNIKRQELFFLYFLSQLGCDILYINPNKDILDLYP
                     ECSKFSTLFELSRKTPNILEIPFERHITNINYSENTNKTSPTTNKPNSKNTLNNTNLT
                     SKKIVQDEEVELSYEDLAKLSASVVMIVVCNNENKPFKSGSGVVINNEGYILTNLHVV
                     NDGYSFLVRFENDDKVYTSYQIIKYHSDYDLAVIKVDRKCKPIPVKVSKKPVRGQKIV
                     AIGSPLGLFNTVSDGIISAFRDFETVQMIQFTAPISSGSSGGALLDMFGNLLGLISAG
                     YDDGQNLNLAVESSLVKIFANNFIEIVN"
BASE COUNT         6215 a         1775 c         2714 g         5572 t
ORIGIN      
        1 tcaaaatgaa ctttttagtt catgaggcac tctttttgta cgaaataaaa tatattttta
       61 ttatttcaac aatgaaaaag atgcttgttt ctattttgag acagtataat ttttatgtaa
      121 ctttaatttt agtaaatata aagttttaaa attgataaaa taggagaaat ttttaatata
      181 aaagggtaaa taaagggttc agagggcata atatagaata aattaatata tttaaggagg
      241 atttttatgt gtaaaaaaac gtatttatta gtggtaagta tacttatagc aggtttatta
      301 actgcatgta gtgggagtcc aactacggat tcaggacaag cacaagataa tacaaaaaag
      361 gaggcaaatg catcaaataa cgctttaaaa gatgaaaaaa ataatgaaaa tttaatggaa
      421 caagatttta aagtgccata cacagatgca ataaacatat ttaaagataa atataaggat
      481 gctgatatag tagatttaag tcttgagaga gatttaaata aatttgttta tactgtggaa
      541 ggtgtagatg ataataatga atataagatg aaaattgatg ctaatacaaa agatgtatta
      601 gaagataaaa cagaaaagtt ggattcagaa gatttaaatg gagttgctag aaaagaaaaa
      661 ttagatttaa atgacataat gacacctcaa caagctatgg aaattgcatt aaaagaacaa
      721 aatggaatag ttaaagaatg gagtttagac aaagatttag atgttacttt ttataaaata
      781 agaatagata aagataaaaa tgaatatgac ataaaagtag attctaaaaa gggaactgta
      841 ttgaaggtag aaaaagaaga ttagaagatt taaactatct ttaaaataat ttcttttttg
      901 aataaatttt gtttaaaata taacaagcag ggtataaaga gactaaataa ctattttagg
      961 aggagtacgg tatgtcattg aaatcactaa aaataaaaga aaatttatat tgggtaggtt
     1021 cacttgaccc tgatttaaga gtatttgaca taattatgta tacaccttat gggactactt
     1081 ataattcata tgtattaaaa ggaacagaaa aaacagtttt atttgagaca gttaaagata
     1141 agcattttga caattatatt gaaagattaa atgatttaaa tatagatttt gaaaaaatag
     1201 actatattgt tgtaagtcat actgaaccag accatgcagg aagtgttgaa aagcttttgg
     1261 atttagctaa aaatgcaaaa gtagtagctt cagaaacagc aattaaatat cttaaggaaa
     1321 tcgtaaacaa agactttgaa tatgttgcag ttacagatgg agatacatta tcaattgggg
     1381 acaaaacttt agaatttttc tctgtaccta tgcttcattg gccagatacc atatacacat
     1441 atataaaaga ggataaaact cttgtaacat gtgattcatt tggtagtcac tatagtaatg
     1501 ataagatagt aaatacactt gatgaaaatg aagaaaagga ttacttggat gctttaagat
     1561 actattatga ttgtataatg ggtccattta aaccatctat ggtaactgct atagaaaaga
     1621 taaaagattt agatatagat actgtatgtc caggtcatgg tccagtatta actgaaaatc
     1681 ctagaaaaat tatagacctt tattacaact ggagtgtaaa tgaacaaata aagttagaaa
     1741 aagaagttac aatttgttat gtttctgcac atggatatac aaagattatg gcagaagcta
     1801 taaaagcata tattgaaaaa aatagcaact ataaagtaaa tttatttgat gtaatagagc
     1861 ataagcaaga agatattttg gcaaaaatag cagtatcaca aggtgtatta tttggaacac
     1921 caacaatatt aggagatgcg ttaaagccta tatgggatat attaatatcg ttaaacccag
     1981 ttcttcatgg tggaaaagtt gcttcagtat ttggttcata tggatggagt ggagaaggta
     2041 tagaaaatgc tatggagaga ataagtcagc ttagaatgac agcagtaaaa ccttttgctg
     2101 ttaactttaa accatcaaat gaagagattg ataaattaca ttcttataca ggtaaattcc
     2161 tagataagtt aaattctact tttggaagta aaaagaaaac taagaaattt aaatgtgtaa
     2221 tttgtaatga agtttttgaa ggtgatagtg ctcctagtgt atgccctgta tgtggagcta
     2281 aggaagacca atttatagaa gttgaagaag atgaagttac ttttagaaaa gatactgatg
     2341 aatatttcgt aatagtaggt aatggagcag ctggttttta tgcagcagat gctataagaa
     2401 aaagaaataa aacttgtaag ataactatga tttctaatga agatgagttg acttactata
     2461 gacctgcact ttctgatggt ataaatgaag aacttggttc agatttctac atggaagata
     2521 aagattggta tgataaaaat aatatagtag taatattagg aacgaatgta gataaattag
     2581 atgaagtgaa taaaactatt atagtgaatg atggagctat taaatttgat aagcttgtaa
     2641 tagctacagg aagtagaaac tttataccac caattaaggg ccatgattta gaaaatgtgt
     2701 ttactcttag aaatataaaa gatttatata gtgtaaaaga agcactagaa aaatctaaga
     2761 aagttgtagt gattggtggc ggtttattgg gacttgaagc tgcatgggaa tttagactaa
     2821 aaggattaga agtagtagta gttgaagcca tggatagcat actatcaaaa caacttgata
     2881 aagaaggtag taaaatatta gaacaatgtg taagagatac aggaatagat gtaagattgg
     2941 gtgtagcagt tgatggtatt gaaggtgatg gaaaagctca aaaagttgta tttaaagatg
     3001 gagatagtgt cgactgtgat atggtagtat tttcaattgg tgtaagagca aacactcaaa
     3061 tggttcagga tacatctgta aaaattgata gaggtattgt tgtagataag acattacaga
     3121 caaatgttaa agatatatat gcttgtggag atgttgcaca agtgggaaat attagtttag
     3181 caatatggcc atcttcagta gaaatgggaa aaatagcagg ggcaaatgca agtggagata
     3241 atttgacatt tgaaagtgaa gtatatccag tttcattaga tgcaatgaat gtaaaagtat
     3301 ttagtattgg taatatacaa aattttgata aagaaatttc atcaaaagat gaaggtcaaa
     3361 gaatatataa aaaattattt atgaaagatg gttcattagt tggagctata cttataaatg
     3421 atttaagctg tactgttaaa ttgataagat taatatctga aaaaggtgat tttgaggata
     3481 ttatgaaggc tgatatacta taatttaaat acattaaaat aaaaaggagt tgtcttaaaa
     3541 ttgatttttt tctaatcaaa ttttaaattc aactcctttt ttgaattttt atataaaata
     3601 acatggaaat tttagtaatg tctgtggtta catacatagg tttaattgtt ttttatatgg
     3661 attgtctctg gtataataaa ttgaattgtg tttgactgat agatattttt attgaaagtt
     3721 aatacctgtt atgcgataat aaggacgtgt taggggagtt tttataataa caattaatct
     3781 cagtttttgt gttccaatag tagcatcaac acattctgat gtagtagttc ttttcttata
     3841 aaaattagtt acaaatatgc ttgtaattat ttgatatgta aatttaccaa tattataaat
     3901 gatgacctcg ataataagga gagtgaaaaa taatctatga acgaaaatat tttgattgtg
     3961 gatgatgaaa aagaaatagc agatttaatt gaagtatatt taaaaaatga aggttttaca
     4021 gtatacaagt tttatacagg taaggaagct ctagaatgta ttgaatctaa aaatttggat
     4081 atggctattt tagatattat gcttcctgat attgatggat ttcatatttg ccagaaaatt
     4141 cgagaaaaat actattatcc tatcattatg ttaacagcta aaattgaaga tatagacaag
     4201 ataatgggtt taaccatagg tgctgatgat tatataacaa agccatttaa ccctttggaa
     4261 gttgttgcaa gagtaaagac acaattaaga agatatatgc gatataataa ttcttatgaa
     4321 caacagtcga taattgttaa tgagtatgat attaaaggat tgattatcaa taaagaaaca
     4381 cataaatgta gtttatttgg gaaagaagta gcattaacac cgattgaatt ttctattctt
     4441 tggtatttat gtgaacatca aggaaaagtg gttccttctg aagaattgtt tgaagctgta
     4501 tggggagaaa aatatcttga taataataac acagttatgg ctcatatagg gcgattacgt
     4561 gaaaaaattc atgaaccttc taaaaacccg aaatttataa aaactgtatg gggagtaggt
     4621 tatacaattg aaaagtaaaa atattaaagt caatcctgac tttactcaag tgagaaataa
     4681 aatttttatg agaacagctt taatggcatt tatagccatt attttcatat ggattttata
     4741 ttcttttata ttgtatggta agttttctat ctggatagta tcattctttg aaaatgcttt
     4801 tcgtatggaa tataaagctg cattgaattt atatcagcag attttccgta atagcatgga
     4861 gctcttcatg atactagcta tggtgattgt gttttttata atattccgtg tttatttaaa
     4921 ttggtttaca aaatatttta gtgaaataaa tcaaggtatt gactctctta tcaaagaaga
     4981 tgttggagaa gtggctttat ctccagagtt attggcaata gaaaagaaaa taaactcaat
     5041 taaacatata cttgaacaac gtaaatttga gacacaaatg gcagaacaac gtaagaatga
     5101 acttattgtt tatcttgcac atgatttaaa aacaccactt acatcagtta tagggtatct
     5161 gacactactt cgagatgaaa gtcagatttc tgaagaactg cgaaaaaaat atttatctat
     5221 ttcgttggat aaggcagagc gtcttgaaga tttaattaat gaattctttg aaattacaag
     5281 gtttaattta tcaaatatat cacttgaata cagtacagta agcttaactc gtatgcttga
     5341 acaactaaca tatgagttta aacctacttt gatgagtaag aatttaaaat atacactgaa
     5401 tgttacacca aatatgatga taaggtgtga tgttaataaa atgcaacgtg tatttgataa
     5461 cttattacga aatgctgttt attatagttt tgaagatact actattgaaa taacagctgt
     5521 acaggaggat gattatataa agcttaaatt tatgaatcat agcaatacga ttccagagga
     5581 aaaacttgag cgtatttttg aacaatttta caggttggat acatctcgta attcaaacag
     5641 tggtagagct gggttgggac ttgctatagc taaagaaata gtggagcttc ataacgggac
     5701 aataacagct catagcgaga acaatataat tacctttaag gttattattc cgattgtagg
     5761 aaatttgtaa gaatttaagt ataaaaaaat aggaaattct ttaggataaa taaataaaga
     5821 gcactcttgt tattgatata attactgtat caaaacaaga gtgcttttat tttgatacag
     5881 taattatatc aatagaaaaa tgtgaaaata tattatgtgg aacagatgca attgtaagtg
     5941 aaggttgatt ggatttgaaa tagaaaaagt attttaacat gtttctgtag attgtataaa
     6001 aataaataaa tcaacaaagg agaatcaaag atgaataata aaaaaattgc agttatattt
     6061 ggtggaaact caacagaata tgatgtatca ttacaatcag cttttgcagt acttgagaat
     6121 ttgaatacgg aaaaatatga tattatacca attggaatta caagggaggg taattggtat
     6181 cattatattg gagattataa taatatccag aataacactt ggtttgaaag ggatactgat
     6241 ataattccag ttattgtttc gcagaaccgt gtcaaaaatg gtattattga atttttaatt
     6301 cctgatgctg tttctcagaa tcatattcca aatagtgcta ttgaatcatg tgaaaatgat
     6361 attaaataca ctaaacttga ttttgtgttt cctgtactgc atggaaaaaa tggagaagat
     6421 ggaacagtgc aggggttatt tgaattggca ggtatacagg ttattggatg tggtactctt
     6481 tcttcagcat tatgtatgga caaagacaaa tcacataaac ttgttcattc agaaggtatt
     6541 aaagtaccaa aatcaatatt actaaaatac tcagataaat ttaatgtggc tgaactgtca
     6601 aaagacttaa cttatccatt atttataaaa cctgtgcgtg caggttcatc atttggtatt
     6661 agtaaaattt ataaaaaaga agagttacaa gtagcagtag acttggcttt tgaacatgat
     6721 aatgaagtaa taattgagga aaatattgat ggttttgagg tagggtgtgc agttttagga
     6781 aacgatgact tacttgttgg aagagtagat gaaatagaat tgtcaaaagg attttttgat
     6841 tatacagaaa aatatacatt gaaaagttca aaaattcata tgccagctag aattgatttg
     6901 gattgtgaga aaagaataca agagacagca aaaattattt atagaactct tggatgttct
     6961 ggatttgcta gagtagatat gtttttaact ccatctggtg aaattatttt taatgaagtc
     7021 aatacaattc ctggctttac ttctcatagt cgttatccaa atatgatgaa aggtattgga
     7081 ctgtcttttg aagaaatatt ggacaagata attgaggtgt acataaaatg atgaataata
     7141 ttttattaga taaaaataaa gaagataaaa tgacaaatac tatcttattg actaaagata
     7201 aagtttatga tgggaatcta attctagtaa atgctttttt accagttaaa acatcagaag
     7261 atatagattt aattcctgta gatacaaggt ttccaagtat tcttatgaaa cgtgaagcta
     7321 caaacatttt acaaaatatt ttaaaaagta tatgtggaat aaatgaaata gtacctgtaa
     7381 gtggatatcg tactgcagag gaacaacaag atatatattc aagttctctg cgtgacaatg
     7441 gaaaagactt tactaaaaag tttgtagcac ttccaaatca cagtgaacat cagacagggc
     7501 ttgctattga tttagggtta aagaaagaag ttatagattt tatctgccct gaatttcctt
     7561 ataatggtat ttgtaatgag tttcgtaagg cagcactaca ttatggtttt atagagcgtt
     7621 atcagtgtaa aaaagaagaa ataacaggaa tatctcaaga accatggcat tttcgttatg
     7681 tgggatatcc gcattctgag attatcaata aaatgaatct cgctcttgaa gaatatatag
     7741 aatatattaa gagattttcg tatacaaatt gtttaaaaat agaagataaa gaaaaaatta
     7801 tagaaatctt ttatgtgcct atccatacta aagaagaagt gagaatctct atacctgaac
     7861 aatgtgtata tcaaatatcg ggtaacaata aggatggttt tattgtgaca ttttggagaa
     7921 atagaaagga ctaagaaatg gaggaacaag aatgattagg aataaatctt atgcagggct
     7981 tgattatttt aggattatag ctgcattact tataattgca attcatacat ctccattatt
     8041 atcatatagt aaaatggctg actttgtgtt aactagtata attgctcgta ttgctgtgcc
     8101 attctttttt atgctatcag gcttttttct aatttcaaca tataattata attgtaataa
     8161 actgaaatct tttctaaaaa atgtattatt tatttacggg atagctattg taatttatat
     8221 tcccttaaat atttacactg gatatttttc catgaataat ttagtgccca atattattaa
     8281 ggacattgta tttgatggga ctttatatca tttatggtat ctacccgcat caattattgg
     8341 tgcaagtatt gcatactttc ttgtaaaaaa actaggttta aagtactcac tagtaatcac
     8401 tattgttatt tatgtaattg gtatgtttgg tgatagttat tatggttttt tagaaaaaat
     8461 accactatta aagaatttat atgggtatat ttttgaagta tcagattata cacgaaatgg
     8521 tatatttttt gcacctgtat ttttcatact tggtggaata atatctaata aatctaatta
     8581 tatgtcaact aaaaatagct tgattggatt tcttatatca ttcttactta tgttatgtga
     8641 gggaatgttt ttacataaac taggggtaca gcgtcatgat agcatgtata ttatgttatt
     8701 gccatgtatg tatttcttat ttacagcctt aacatttttg aaaggttctc gagctaggtt
     8761 attgcgaaca tcatcattaa ttatttatat tatacatcct atgatgattg ttgttattcg
     8821 tatgttttct aaaatattcg gaatacaaac tgtcttggtt gacaatagcc ttattcatta
     8881 tatagtggta agtatagcat cttttatagc ttctataatt attatattga ttcttaaaca
     8941 tctaaaaaaa gacttgaaag gagaacataa ggtaaatacc aatagagctt ggattgaaat
     9001 tgatttaaat aatttggaac ataatgtaaa tatgatacaa aaagctatgc cagaagattg
     9061 tgaattgatg gcagttgtaa aagctaatgc ctatggtcat agtgcttttg aagtagcgac
     9121 ttgtgcaaac caaataggtg taaaagcatt tgcagtagca acaatagatg aggggattga
     9181 tttacgtcga tatggaatac taggagaaat attgattctt ggatatacta acccaataag
     9241 ggcaaaggaa cttcataaat acaatcttac acagagtgtt attgacctta atcatgctat
     9301 ctctttaaac aaacagaaat acaacataaa atcacacatt aaaattgata caggtatgca
     9361 cagactgggt tttgatgtta atgatgtgag gtcaatttta aaggcattta aattaaaata
     9421 cttagatata tgtggcatat ttacacactt gtgtgtttca gatagtctga aagatgaaga
     9481 tgtagacttt acaaataaac aaattgaatg tttttataag ttaattgatt ttctgttaaa
     9541 aaaaggtata aaaattccta aagtacatat tcaaagtagt tatggttttt ttaattatcc
     9601 caatcttaag tgtaattatg taagaattgg aattgcatta tacgggatat taagttctcc
     9661 aaatgatacg actaaattgc aacttgattt acgacctgtt ttatccttaa aatcacaagt
     9721 aattcttatt agaaaaatac aaaaagatga tagttttgga tatggaagag tctttattgc
     9781 aagcagagat agcgtaattg ctatattatc tattggctat gccgatggta tacctagaaa
     9841 tttatcctgt ggaaaaagtt acgtaataat aaatgattgt agagcagcaa tagtgggtcg
     9901 aatttgcatg gaccaacttg ctgttgatat tacagatata cctaatgtag aagttggtaa
     9961 tacggcaata ataataggaa gagataattt agctgaatta tctgcttctg aagttgcaaa
    10021 taactcatgt agtatatcaa atgaattatt gagcagagta ggaagaaggt taaatgttat
    10081 aaagaagtaa ctcaattaaa tagtaatatt tgttatactg tgtaatttat tttactctga
    10141 ctagacattt ttagtaatat tatgtctaat atatattttt tataacttac atgacaattt
    10201 aagttataaa aaggtgatgt ttcagatttt tattttgaaa catcaccttt tttgttataa
    10261 tatataataa aataattata ccttaactgt aaacttatat agattattta ctttttaata
    10321 ttagattcat tttttgagat tggtatataa taaacatata gagtatataa taatagttaa
    10381 agttaaaaaa ggggaaaagc aatatgcagt atatacaaga actacttgat ttgactcaaa
    10441 attattgggt gttagccaca ataatcggct tattaagtgc atttatagaa agctttatac
    10501 cagccttacc acttgttgct atagttacag caaatgctgc aatacaagga ttatttattg
    10561 gatgtttgtt atcatggatt ggctcaggac ttgggacaac ttcattattc ttattaataa
    10621 gcagatttaa tgatagtaag ctttttaata agttgagaaa tagtaaaact gaaaaagcaa
    10681 taagttggat ggataaacag ggatttaagt tattatttat agcgtatgcc tgtccattta
    10741 tgcctggttg tttagttact atcgcatcag cttttggtaa aaaagattta aaagattttg
    10801 tgccagcaat gttggcagga aaatttgtaa tgtttatagt tataagttac gtggcaagtg
    10861 atatagaagg ttttataaca agtcctttaa agatagcatc atttatatta ttggtgtttt
    10921 tgtcatggaa gattggaaat agagtaaata aaaatcttga aaatcataat tatgatttcc
    10981 atcataaaaa acatcacaat gataaagatg ataaaatgat ttagcttgta cgaaataaaa
    11041 cgtatcttaa aatgatttag tactaaatta ttttaagata cgttttattt tttgtattaa
    11101 ggtacaaaat ttttagttct tttgtaaact aaaatatata aaacttattt atacttagtt
    11161 caaaatattg ttatttattt tttctacaac tataataaaa tataaaattg atatccaatc
    11221 aaaaaaataa ctatgaaatt taatagctta gatatgaatt tttctgtttt tgagttagtt
    11281 tttataggta gtaaagaaat gtttatggta atgggataaa acaattcaat accttcttta
    11341 gtaataaggt caagacacaa gtgagataga tatcctatta taaacccact ggacaaacat
    11401 gagaaaacta tattattgtt agtgaagatt gtcagagatt taaaaaaact ataaataagt
    11461 aataaggcaa ttagactgtg agtaaaccct ctatgtctaa acctacttcc aaataatttg
    11521 tatattaaca taaatttttt acttatgtaa gaacctctca tatctatatc tggaaataaa
    11581 gaacctaaat atgcaaaata aatataaatt ataattaata ctattttata tgcaatatcg
    11641 tatttaacta ggtacagatt gtttataaag gggagtatca aaagtgcgaa tatataacct
    11701 cccctttcat gtgtttcttt tatcatataa aaatcctcct gaatcgtcac tataaacatt
    11761 atattggtaa atttagacta tcttttatta tattatatag caaacataag tttttttcaa
    11821 aaggatttta atatttaatt aatcttgaga ttttaaattt ttgtaatttt ctaaagcacc
    11881 attccaattt actacattaa accagttgtc aatgtattca tttcttctat tttgatattt
    11941 taaatagtaa gcatgctccc aaacatcaag tcctattata ggagttaggt ttttacttac
    12001 agggctatcc tgatttggag tagtcataat agataatttg ccatctttag tagctataag
    12061 ccaagcccaa ccagaaccaa agacatctaa agcagatttt tggaactctt gcttaaattt
    12121 ttcaaaagaa ccaaagtctc tatcaatagc ttcttttaaa gattcagaag gtatggtttt
    12181 ttctggtgtc attatatcaa aaaagaattt atgattataa gctccacctg cattatttct
    12241 tacagttgta gcaatatctt taggtaaaga atctaaattt tgcaataatt cacataaaga
    12301 ataattataa agctcaggat atttttcaag agcagcattt aatttatcaa cataagcttg
    12361 ataatgctta tcatgatgca gtttcattgt ttctttatct atataaggtt caagtgcatc
    12421 atatgcataa ggtaatggtt taaccttaaa tttgttattt tcaggtgtaa aagcaaatga
    12481 agttatgcac tgtgagatta taaataaaga cataataact ggtattaata tttttttctt
    12541 cataaaaatc acctcctaat atagtatttc tagaaataaa aaaaatatga aatattaaca
    12601 gataatttat aagaatttaa tagcaatttc attttaaatt gaataagttt taaagccaaa
    12661 gacaaaacta tgaaatatag aataagacta aaggacagaa aggaattttg attatatgga
    12721 cggcaatatt tcaatttatt ataaaggtga tatatctaaa aaagaagata ttaaatttaa
    12781 aataaaagaa tctgtaaata atacaagact ttctagtaga atagagtata aggatgagga
    12841 aaaaactttt gattttgaaa gatttaatgt aattgatgct atttatggaa ataaaccatt
    12901 tgaaaaagat ggaaaagtta ttgtttttaa tggaaatata tataactatc atgaaataaa
    12961 agaagaatta attaaaaaag gacacaattt tactacaaat gatgatattg aagtcttatt
    13021 agcatcttat atagaatttg gtaagaattg tgtacataag attaaaggaa tgttcaactt
    13081 tataatctat gatagagaaa atgaaagtat atttggagca agagatttat ttgggataaa
    13141 accactttat tatataaata aggaaaatgc aataattttt tcctcagagt ataagttttt
    13201 acttgaatat atgaaaaatt taaatataaa tgaaagaagc ttacaaagtt atttttcatt
    13261 tcaatatgta cttcctgaag atactatgat acaaggaata aggctgatac cagcaggtca
    13321 ctattttagg gtagaaaatg gtatactatc tttaaagaga tataataaac ttgagtttag
    13381 aagtagtaca aaattttttt atactaaaaa tcacttaggc aatagagatg tgaatgagga
    13441 tgatataaga aatatagtag tagattcaat agtaactcat atggaagagg agaaagaaat
    13501 tggaacattt ttgtctggtg gaatagattc atctattata actactgtgg cttcacaaat
    13561 taatccaaat ataaaatctt tttctgcagg ctttagtgtc aaaggatata gtgaattaga
    13621 agtagcaaag aaaacagctg ataagttagg tatagaaaat atccagatta atataacaca
    13681 agatgaatat ataaaatcat taccgaatgt aatttattct ttggatgacc ctatagcaga
    13741 cccttcagaa gtaggtcttt atttcttaat taaagaggca ggtaaacatg ttaaagtagc
    13801 attgtctgga gaaggagcag atgaattatt tggaggatat aatatatata aagagtatag
    13861 tactatgaaa tcagttgtca attcacctac ttatattaaa agtatattag gaagagtttc
    13921 agaacttatg ccaaacataa aaggaagaaa ttatctttat agagctacaa caccattaga
    13981 aaaaagatat ataggaaatg caaaagtttt tgaaaacagc gaagtaaaaa gattcttttt
    14041 taagtataag gaaaagaata tatatgaata cctgttgtct aatttgtata gagatgcaca
    14101 aaaaaataat tacgattata taagtaaaat gcaacatata gatgtgaata catggcttca
    14161 aggcgatata cttcaaaaaa ttagcaaact ttctacagct gagcaggttg aacttagagt
    14221 accattttta tataaagatg tatttgatgt cgcaaaaaat ttaagaatgg agcaaaaaat
    14281 aaataagaat aatacaaaag ttttacttag agaggcgttt agagaaatag tcccagaaca
    14341 tgttgttcaa aggaaaaaat taggatttcc aactccaata agagtttggt taaaagattc
    14401 tctaggggat attgtaaagg aaactattta taattcaaat gtagatgaat ttatagataa
    14461 aaaatatgca ataaaacttt tagatacgca tcttaaaggt catagagata attcgagaaa
    14521 aatatggact atatttacat tttgtctatg gcatcaatta tttattgagc ataaaaatgt
    14581 cgagtattaa tacttttttc aatattaatc agagggcaaa agcatgcaat gttttcaccc
    14641 tcttgattat tatggaatag gataagtaga attttgattg attagtttac tatctcaata
    14701 aaattattgg caaatatttt gacaagacta ctttcaacag ctaaatttaa gttttgtcca
    14761 tcatcatatc cagcggaaat caatcctagt aagtttccaa acatatctaa aagagctcct
    14821 cctgaactac cactagagat tggagctgta aattgtatca tttgaaccgt ttcaaaatca
    14881 cgaaaagctg aaataattcc atctgaaact gtattaaaaa gacctagagg gcttccaatt
    14941 gcaactattt tttgacctct cacaggtttt ttactgactt taacaggtat tggcttgcat
    15001 tttctatcaa cctttatcac agctaaatca taatctgaat ggtattttat aatttggtaa
    15061 gatgtataaa ctttatcatc attttcaaat ctaactaaaa atgaataccc atcattgact
    15121 acatgaagat tcgtaagtat ataaccttca ttatttatta ctactccaga accgctctta
    15181 aacggtttat tttcgttatt gcacacaaca atcataacaa cagaagctga taactttgca
    15241 aggtcttcat aagaaagttc tacttcctca tcttgtacaa tttttttaga tgttagattt
    15301 gtgttattaa gtgtattttt agagttaggt ttattcgtag taggagaagt cttattggta
    15361 ttttcactgt aatttatatt tgtaatatgc ctttcaaaag gtatttctaa tatatttgga
    15421 gtcttcctag aaagttcaaa tagagtagaa aattttgaac attcaggata taaatcaaga
    15481 atatctttat ttggatttat atataaaata tcacacccaa gttgtgataa aaaatataag
    15541 aaaaaaagtt cttgcctttt aatatttcca aagtatacta tctttggtga aatagtagtc
    15601 ttcaccttgt tataaaataa tttaggtaga aaatagtcta tccaacacaa aagtttaact
    15661 gcaaagtttt tgatgataga ggatgtacaa tttggcatac ttgtggaaaa taaatctaaa
    15721 gtatttttaa atgcaatctt tttagtccaa tttaaggtgt cattttctat tttacatgga
    15781 aagtcgatat tatataaatc ccaactgtta aacttagaac tattataaat attaaaaatt
    15841 ttaagcatct tatctgtttg ttctttgtca aaatttattt ttagattgtt taatctaata
    15901 tagggaattg taggattatt aaaaaaataa gtatctatat ttttaatttt ttctatgtat
    15961 ttatcaattg aatcatcaac acctatatat cttgtaaagt agacttcttt aatatatgaa
    16021 gaactcttat ttttataggt agtatcagat ataaattcaa ttagaggttc agtagacttt
    16081 tttattgaaa tctttaatgg tttaatagta caaatcatat tttttctcct ataataagat
    16141 gatataatct attataaaac aacttaaaac aatatagtac aataattttg tagtttcaaa
    16201 ataaaatatg tacttgttta tataaatgat atataattac aataaaattg ccgaaaagcc
    16261 ctctccttta ggtgta
//
LOCUS       DAEQCW010000308         1340 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.guided.245, whole genome shotgun sequence.
ACCESSION   DAEQCW010000308 DAEQCW010000000
VERSION     DAEQCW010000308.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1340)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.guided.245"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            278..1231
                     /gene="blaCDD"
                     /locus_tag="KRO40_003720"
     CDS             278..1231
                     /gene="blaCDD"
                     /locus_tag="KRO40_003720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBH2094484.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYLGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNDKNKKEKINMVDYSDCFEDISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLINKVDAKYVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDVNDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
BASE COUNT          575 a          106 c          224 g          435 t
ORIGIN      
        1 attgtaatat ttaaatatta caatagtaag ttttaaatgt ggaatcaatt attatatcac
       61 aaattaaaag gaggacagga tgttattaat agttacctaa ttatcttcgc aataggttta
      121 atcaacataa ttgtactagg tgaagaaaat ataagagata cagctattca tttagtcttg
      181 tttcttataa gtagaaccta gattggagta tattacaaat aatgtatact attttaatag
      241 taggttataa atttaaatat gggagatgat ataaattatg aaaagaaaaa agaattttat
      301 ttggatagct atcttattgg ttggtgtagt tatggtaatg tattatttag ggaaaaaaca
      361 taacgatata aatcaaaaaa ctgataagaa ttatataaaa tctgaattaa ataagtctga
      421 attaaataaa tccaaaattg aaaacaatga taaaaacaaa aaagaaaaaa ttaatatggt
      481 tgactatagt gattgttttg aagatattag tggaggagct attttttata atactaaaaa
      541 taaagaatat aatatatata acaaagaatt aattgaaaca agaaggtcac catgttctac
      601 ttttaaaata gtttcaactt taattggttt agaaaaaggg gtaataaatt caaaagaatc
      661 agttatggga tatgatggta cagagtatcc aaataaaaat tggaataaaa atcttagttt
      721 agaagaggca tttaaggagt cttgtgtttg gtactacaaa aaattgataa ataaagttga
      781 tgctaaatat gtccaaaaca ttttagatga tttaaagtat gggaattgcg atattagcga
      841 atgggaagga gatttaaaaa atggaaaggg acatttaaat ggattttggt tagaatcttc
      901 attacaaata tctccaaaag aacaagtgca aacaatggca aaaatatttg agggagatac
      961 aaactttaaa aaagagcata ttaatatttt aagagatatt atgaaaatag atgtaaatga
     1021 taaaaacata aatgtatatg gaaaaactgg aacaggattt gatgaaaaaa ataaacgtgt
     1081 ggatgcatgg tttgttggta tgctagagcg tgaaggtgac acctattatt ttgctattaa
     1141 atcagatgat tccaataaag aaattacagg gccaaaggta aaggaaattg caattaatat
     1201 aattaagaaa tattatagtg taagggaata aacttaattt tatttgtaaa tattatttac
     1261 ctatagtctg taatatttat taaataattt tactaaattg agtctatata gagcaaaact
     1321 cctttagtac ataaaatact
//
LOCUS       DAEQCW010000309          676 bp    DNA     linear   BCT 18-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile isolate Clostridioides difficile
            SAMEA5556060-rid12476083.guided.276, whole genome shotgun sequence.
ACCESSION   DAEQCW010000309 DAEQCW010000000
VERSION     DAEQCW010000309.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA5556060
            Sequence Read Archive: ERR3289203
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 676)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 14-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001069312.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001069312.1
            Genome Coverage       :: 116x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/14/2021 20:13:02
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,721
            CDSs (total)                      :: 3,677
            Genes (coding)                    :: 3,638
            CDSs (with protein)               :: 3,638
            Genes (RNA)                       :: 44
            rRNAs                             :: 2, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 30
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 39
            CDSs (without protein)            :: 39
            Pseudo Genes (ambiguous residues) :: 0 of 39
            Pseudo Genes (frameshifted)       :: 20 of 39
            Pseudo Genes (incomplete)         :: 15 of 39
            Pseudo Genes (internal stop)      :: 14 of 39
            Pseudo Genes (multiple problems)  :: 9 of 39
            CRISPR Arrays                     :: 9
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA5556060-rid12476083.guided.276"
                     /isolate="Clostridioides difficile"
                     /isolation_source="Human feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="Spain"
                     /collection_date="2014-04-28"
     gene            2..628
                     /locus_tag="KRO40_003721"
     CDS             2..628
                     /locus_tag="KRO40_003721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014117022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBH2094485.1"
                     /translation="MPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYNDPR
                     DFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEWKL
                     DINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSIVG
                     GVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
BASE COUNT          272 a           77 c          103 g          224 t
ORIGIN      
        1 tattccaagt tcaaataagg tatatccaag aagtaatgat tatcaaactg tatatcttaa
       61 aaatgtaata acaagggaaa atatagaagt tggagattac acaatatata atgactttta
      121 taatgaccca agagattttg agaaaaacaa tgtattgtat cattacccta taaacaatga
      181 taaattaata attggtaagt tttgctcaat agcatgtaat gcaaaatttc taatgactag
      241 tggaaatcac tcaatgaaat caaaatccac atatactttt cccatctttt atgaagaatg
      301 gaaactcgat atcaaccata taacggacgc ttgggacaat aagggtaaca ttataattgg
      361 aaatgatgtg tggataggtt atgattctat aattatgtca ggtgtaaata ttggtgatgg
      421 tgcaattatt ggaacaagag cagtagttac taatgacgtt ccaccgtatt ctattgttgg
      481 aggagtacct gcaaaaatta taaaaaagag atttaataat gatacaattt caaaattatt
      541 agaaattaaa tggtgggatt ggccatataa aaaaattcaa tcaaacatta agcatattca
      601 atcaggaaat attgataaat tagtttaata ttttataatt tatttatatt aaactttact
      661 ttaataatca ttttat
//
